BICYCLOOCTANE DERIVATIVES AS PLASTICISERS

Abstract: The use of isosorbide esters, isosorbide polyesters, isosorbide ethers, isosorbide carbonates, isosorbide thioethers, isosorbide thioesters, isosorbide amides, isosorbide (thio)urethanes, isosorbide urea, isosorbide phosphates and isosorbide phosphonates as a plasticiser is described. Instead of isosorbide it is also possible for corresponding diols such as isomannide and similar compounds, in which the ring oxygen atoms of the isosorbide have been replaced by carbon or by other heteroatoms, to serve as a base. In particular, this relates to C<3>-C11 alkanoates of isosorbide, isomannide and the like. In particular, the compounds are used as a plasticiser in poly(vinyl chloride), optionally in conjunction with usual plasticisers such as dioctyl phthalates.

Description: Bicyclooctane derivatives as plasticisers The invention relates to the use of bicyclo[3.3.0]octane derivatives as plasticisers or solvents for polymers, including thermoplastics. Plasticisers are indispensable components for thermoplastic materials such as poly(vinyl chloride), and other polymer systems. The most commonly used plasticisers are diesters of dicarboxylic acids, among which the phthalic acid diesters are frontrunners in the plasticiser market with 89%, about half of which is made up of the isomeric diisooctyl esters. Whilst the existing plasticisers are generally satisfactory, there is a need for the range of plasticisers to be extended. Moreover, the existing plasticisers are virtually without exception based on petroleum products, whereas it is desirable for these to be replaced, as far as possible, by renewable raw materials. From an environmental and health point of view it is likewise desirable for dialkyl phthalates to be replaced. Polyesters based on isosorbide and dicarboxylic acids (adipic acid, suberic acid, sebacic acid and dodecanedioic acid) having molecular weights above 10,000 have been suggested by Braun and Bergmann (Angew. Makromol. Chem. 199 (1992), 191-205) as plasticisers for PVC. JP-A-8-173788 describes the use of fatty acid diesters of sorbitans and isosorbide as an emulsifier. JP-A-59- 175408 discloses the cosmetic use of esters of isosorbide with fatty acids having more than 8 carbon atoms. WO 96/33689 describes the use of a plasticising solvent, including dimethyl isosorbide, in film-forming water-in-oil emulsions for use in cosmetics. We have now found that esters and ethers based on isosorbide and analogous derivatives having a low molecular weight have excellent characteristics as plasticisers and solvents for polymer materials. The derivatives are defined in the appended claims. The central unit of these derivatives is a bicyclo[3.3.0]octane-4,8-diyl system, whose carbon atoms in the 2- and 6- position may be replaced by a heteroatom, such as sulphur and in particular oxygen. The attachment of side chains in the 4- and 8- positions can take the form of an ether, ester, (thio)carbonate, thioether, thioester, amide, (thio)- urethane, urea, phosphate or phosphonate. Esters are preferred, but carbonates, urethanes and especially ethers can also advantageously be used. Phosphates and phosphonates are preferred when in addition to the plasticising effect a flame retardant effect is desired. The side chains thus attached are preferably medium-length alkyl groups. Medium length means at least 3 carbon atoms, preferably at least 4 carbon atoms, especially (for ethers) at least 6 carbon atoms, up to 10 or even 12 carbon atoms. Where reference is made to alkyl, alkenyl etc., these terms include both linear and branched groups; depending on the particular use. branched groups, e.g. isobutyl, isooctyl, isononyl, 2-ethylhexyl and the corresponding acyl groups, or unbranched groups may be preferred. Examples of suitable alkanoyl groups include butanoyl, hexanoyl, 2-ethyl- hexanoyl, octanoyl, decanoyl, and unsaturated groups such as benz(o)yl and undecenoyl. Mixtures of alkyl groups are suitable as well, their average chain length is preferably C 4 -C 12 . It is also possible for oligoester side groups of a diacid and a diol, for example succinic acid, which may or may not be substituted, and isosorbide, or of a hydroxy acid such as hydroxystearic acid or caprolactone, to be attached, with an alkyl or alkanoyl group as the terminal group. The chain length of such oligomeric side groups is 1-20, preferably 1 -10, most preferably 1-5 repeating units on either side of the central unit, with molecular weights preferably between about 600 and 2000. The derivatives according to the invention can be prepared in a manner known per se. Derivatives where X represents an oxygen atom in formula 1 can be prepared starting from isosorbide or the isomeric dianhydrohexitols such as isomannide and isoidide. The dianhydrohexitols can in turn be obtained from the corresponding monosaccharides (glucose, mannose) and di- and polysaccharides (sucrose, maltose, lactose, starch, cellulose, galactomannans and the like). Derivatives where one of the atoms X is a nitrogen or a sulphur atom can be prepared in a similar manner from a suitable amino or thio sugar. Derivatives where both atoms X are sulphur atoms can be prepared starting from l,4-dithiapentalen-3-one which, by reduction and addition, can be converted into a 4,8-disubstituted 2,6-dithiabicyclooctane. Derivatives where one of the groups Y contains a nitrogen or sulphur atom can be obtained from the corresponding 2-amino- or 2-thio sugars, such as a hydrolysis product of chitin. The side chains can be introduced by esterification (eg. using a reactive carboxylic acid derivative), etheri- fication, isocyanate addition, and the like. Polyester side groups can be introduced in a manner known per se, by polycondensation of the suitable dicarboxylic acids and diols or hvdroxv acids. The derivatives according to the invention can be worked into polymer materials in a manner known per se. In general, the polymer and the plasticiser can be mixed in a ratio of between 100: 1 and 1 :9. The ratio is preferably from 10: 1 to 10:8. In addition to the plasticisers or plasticising solvents according to the invention, other customary components are used such as stabilisers, flow improvers, pigments, antioxidants, UV absorbers, flame retardants. fillers, oligomeric or polymeric resins or varnishes, reactive monomers, activators, starters, desiccants, lubricants, waxes, solvents, biocides and the like. This may involve, for example, organic compounds of calcium, magnesium, zinc or barium, β-diketo compounds, β-ketoesters, β-aminocrotonates, uracil derivatives, dihydropyridine derivatives, sterically hindered phenols, sterically hindered amines, phosphites, polyols and hydrotalcites. It is also possible, advantageously, for the plasticisers according to the invention to be combined with known plasticisers such as dialkyl phthalates, dialkyl adipates, dialkyl azelates and dialkyl sebacates, alkylbenzyl phthalates, trialkyl trimellitates, triaryl phosphates, citric acid esters, alkyl benzoates and polyesters based on adipic acid or azelaic acid, and thus for an optimal combination to be achieved in terms of compatibility, renewability, degradability, and plasticising properties. The derivatives according to the invention can be used for plasticising and/or solubilising any polymer systems, including thermoplasts (PVC etc.), rubbers, inks, coatings, adhesives, sealants, foams and thermosetting resins. Examples of the use as plasticiser are given below. The plasticisers are used in a manner known for plasticisers and plasticising solvents, as described e.g. in: I. Skeist (ed.), Handbook of Adhesives, 3rd ed., Van Nostrand Reinhold, NY (1990), and H.F. Mark, Encyclopedia of polymer Science and Engineering, 2nd ed., NY (1985). Sealants: The derivatives of the invention can be used as a plasticiser in sealants and caulks, for example in a one or two-component polysulphide sealant or in acrylates or polysiloxanes or natural or synthetic rubbers. In addition to the plasticisers, other components may used in a sealant: epoxidised unsaturated oil (soy, fish, linseed oil), inorganic pigments, desiccants, fillers, and activators such as silica, calcium carbonate, titanium dioxide, lime, zeolites, and adhesion aids, such as organosilicon compounds, and aqueous or organic solvents). Example: general 50 % liquid polysulphide polymer 30-70% 4 % epoxidised soya oil 0-10% 2 % silica 0-5% 22 % titanium dioxide general: inorganic pigment 1-25% 5 % calcium carbonate in general: 2 % lime fillers, activators etc. 1-15% 2 % zeolite 4 % calcium peroxide (curing agent) 1-10% 2 % plasticiser according to the invention 1-20% 1 % 3-aminopropyltriethoxysilane 0.1-2.5%) Remainder: toluene Printing inks: The derivatives of the invention can be used as plasticiser or solvent in printing ink formulations for application in letterpress (relief), gravure (intaglio), offset lithography (planographic), screen (stencil), electrostatic (reprography) and jet (ink spray) printing. Suitable polymer systems for printing inks include acrylates, rosins, polyamides, polyesters, hydrocarbon resins, alkyd resins, nitrocellulose, cellulose acetates, etc. Example of flexographic ink formulation (phr = parts per hundred): 35 phr titanium dioxide 5-45% 12 phr polyamide resin 5-25% 2 phr nitrocellulose 1-10% 3 phr plasticiser of the invention 2-20% 5 phr isopropyl acetate general: 43 phr isopropanol 20-60% solvent e of gravure ink formulation: 10 phr organic pigment or dye 1-15% 5 phr inorganic extender 1-20% 5 phr plasticiser of the invention 2-20% 12 phr acrylic varnish general: 38 phr nitrocellulose varnish varnish 20-80% 5 phr wax compound 2-8% 15 phr ethanol general: 10 phr isopropyl acetate solvent 5-35% Example of gravure ink formulation: 12 phr organic pigment 1-15% 10 phr titanium dioxide general: inorganic pigment 1-20% 4 phr plasticiser of the invention 2-20% 15 phr maleic varnish general: 40 phr nitrocellulose varnish varnish 20-80% 4 phr polyethylene wax 2-8% 10 phr ethanol general: 5 phr isopropyl acetate solvent 5-35% Example of screen-printing ink formulation 3 phr organic pigment 2-20% 25 phr talc 5-40% 36 phr acrylated monomer general: 26 phr 1,6-hexanediol diacrylate reactive monomer 40-75%) 10 benzophenone general: initiator 1-15% 3 phr plasticiser of the invention 1-20% Adhesives and coatings: The derivatives of the invention can be used as plasticisers in adhesives. Their function is to improve the flexibility, wetting properties and water resistance. The derivatives of the invention are applied as plasticiser for adhesives and sealants of the following classes: natural rubber; synthetic rubber, e.g. butyl, nitrile, neoprene, isoprene, styrene-butadiene rubber and copolymers thereof; carboxylated rubber and carboxyl functional polymers, e.g. and acrylic acid polymers and copolymers; phenolic and amino resin (e.g. urea, melamine); polysulphide resins and adhesives; epoxy resins and adhesives; polyurethanes and isocyanate-functional adhesives; polyvinyl alcohol and polyvinyl acetate and acetal adhesives; acrylate, cyanoacrylate and acrylic acid adhesives and their copolymers; polyester and polyamide; silicone adhesives The types of adhesives include: reactive one-and two component adhesives; hot-melt adhesives; delayed-tack adhesives; solution adhesives; in particular pressure-sensitive adhesives. Example: two-component vinyl flooring adhesive Part A: general: 212.5 phr hydrocarbon resin resin 37.5 phr mineral spirit solvent 12.5 phr plasticiser of the invention plasticiser 12.5 phr methanol solvent 7.5 phr nonionic surfactant surfactant 50 phr clay filler Part B: 100 phr high-solids SBR latex latex/polymer 0.5 phr phosphate stabiliser 0.5 phr potassium hydroxide 0.1 phr defoamer Water to total solids content 60% water Rubbers and thermoplastic elastomers: The plasticisers of the invention can be used as plasticisers in cured or non-cured natural and synthetic rubbers, and in thermoplastic elastomers. These include all common rubbers, in particular acrylonitrile butadiene rubber (NBR), chloroprene rubber (CR), styrene butadiene rubber (SBR), polybutadiene (BR), 1 to 100 parts, in particular, 5-30 parts. The derivatives are used for decreasing the glass temperature of the rubber and for increasing tensile strength and strength on rupture. Thermosets: The plasticisers of the invention can be used as plasticisers in thermosetting resins (e.g. polyesters, amino resins) in order to improve the toughness and elongation. Foams: The derivatives of the invention can also be used as plasticisers in polymeric foams, in particular polyurethane, polyether and latex (natural or synthetic rubber) foams. They can be used to increase compression strength of the foam, refine the cell structure, improve its insulation resistance and increase its tenacity or other chemical, physical or mechanical properties. Example 1 : Preparation of isosorbide dioctanoate (ISDO) In a 500 ml flask, provided with a Dean-Stark apparatus, a solution of 25 g (0.171 mol) of isosorbide, 54 g of n-octanoic acid (0.375 mol) and 1.0 g of p- toluenesulphonic acid was boiled for 2 hours in 130 ml of xylene. After cooling, 250 ml of diethyl ether were added and the solution was washed with 1225 ml of 0.1 M NaOH and then with water until the water phase remained neutral. The organic phase was evaporated, whereupon 65 g (95%) of product were isolated. 13 C-NMR (δ, ppm, CDC1 3 ): 13.9 (-CH 3 ), 22,5 + 24,7 + 28.8 + 31.1 + 31.5 + 33.8 + 70.2 + 73.3 (-CH r ), 73.6 + 77.7 (CHO), 80.6 + 85.8 (CHOR), 172.7 (OCO). Examples 2-5: Preparation of isosorbide dibutanoate (ISDB), isosorbide dihexanoate (ISDH) and isosorbide bis(2-ethylhexanoate) (ISDEH) and isomannide dioctanoate (IMDO) Using the method of Example 1, starting from the appropriate alkanoic acids and dianhydrohexitols, the title compounds were obtained: ISB: Yield 87%, 13 C-NMR: 13.3(-CH 3 ), 18.1 + 35.5 + 70.2 + 73.0 (-CH 2 -), 73.6 + 77.6 (CHO), 80.5 + 85.7 (CHOR), 172.1 (OCO). ISH: Yield 86%, 1 C-NMR: 13.5 (-CH 3 ), 22.0 + 24.2 + 31.0 + 33.7 + 70.1 + 73.0 (-CH r ), 73.6 + 77.6 (CHO), 80.5 + 85.7 (CHOR), 172,1 (OCO). ISEH: Yield 89%, 13 C-NMR: 1 1.5 + 13.6 (-CH 3 ), 22.4 + 25.1 + 29.1 + 31.4 + 70.4 + 73.0 (-CH,-), 46.7 (-CH-), 73.4 + 77.5 (CHO), 80.5 + 85.9 (CHOR), 174.8 (OCO). IMO: Yield 91 %, 13 C-NMR: 14.0 (-CH 3 ), 22.5 + 24.8 + 28.8 + 28.9 + 31.6 + 33.9 + 70.4 (-CH r ), 73.5 (CHO), 80.3 (CHOR), 173.2 (OCO). Example 6: Preparation of plasticised PVC A two-roll calender was used to make a film from the PVC compound at 142°C, followed by determination of the glass transition temperature (Tg) by means of DMTA (Dynamic-mechanical thermal analysis). 100 parts of PVC 50 parts of plasticiser according to Example 1 1.0 part of hydrotalcite 0.3 part of zinc laurate 0.3 part of calcium stearate The Tg was 0°C; that of non-plasticised PVC that otherwise had the same composition was 80°C, and that of PVC plasticised with the same amount of dioctyl phthalate (DOP) was -13°C. The modulus of elasticity at -20°C was 10 9 Pa, at 40°C 10 7 Pa and at 100°C 3.10 6 Pa, values comparable to those of PVC plasticised with DOP. Example 7: Preparation of plasticised PVC A film obtained according to Example 6 on the basis of the following compounds: 100 parts of PVC 30-50 parts of plasticiser according to Examples 1 -5 1.0 part of hydrotalcite 0.3 part of zinc laurate 8 0.3 part of calcium stearate was made into small rods whose glass transition temperature was determined by means of DMTA and whose modulus of elasticity and breaking behaviour were determined on a tensile testing machine. The results - as yet not optimised - were compared with those of dibutyl phthalate (DBP) and dioctyl phthalate (DOP) and are shown in Table 1 : Table 1 plasticiser amount Tg(E"max) E(Mpa) at breaking breaking (phr) (°C) T=17,6°C tension elongation (MPa) (%) ISDB 30 25 670 28 165 ISDH 30 21 310 26 142 ISDEH 30 26 n.d. n.d. n.d. ISDO 30 18 600 24 135 IDMO 30 27 390 29 207 DBP 30 14 110 18 159 DOP 30 23 240 17 130 ISDB 50 2 12 18 193 ISDH 50 -7 14 10 149 ISDEH 50 -5 11 1 1 234 ISDO 50 -9 15 18 228 IMDO 50 -20 26 15 152 DBP 50 -16 7 13 237 DOP 50 -13 21 14 205 none - 85 n.d. n.d. n.d. n.d. = not determined Example 8: Preparation of plasticised NBR To a commercial acrylonitrile-butadiene rubber (NBR) compound containing carbon black, stabilisers, crosslinkers and further conventional additives was added 20 phr of plasticiser according to the invention (isosorbide bis(2-ethy!hexanoate ISDEH) 40°C. After extensive mixing, the mixture was vulcanised at 170°C in a die having dimensions of 180 x 120 x 1 mm. The vulcanisation time was 7 minutes. The vulcanised material was conditioned at 50% relative humidity for two days and punched in accordance with ISO 37. The mechanical properties were determined using a tensile strength tester (Zwick Z010). The E-modulus was determined at 1 mm/min, the other properties at 500 mm/min, in accordance with ISO 1 184. Table 2 shows the results, with standard deviations in parentheses. Table 2 Property without 20 phr 20 phr unit plasticiser DOP ISDEH E-modulus 7 (1) 2 (0) 3 (0) N/mm 2 Stress at 100% strain 4.2 (0.1) 1.5 (0.1) 1.6 (0.2) N/mm 2 Stress at 300% strain 15.1 (0.5) 7.1 (0.3) 7.7 (0.4) N/mm 2 Stress at break 15.4 (1.8) 13.0 (1.4) 13.0 (0.8) N/mm 2 Strain at break 354 (49) 499 (38) 469 (26) %

Claims: 10 CLAIMS 1. Use of a bicyclo[3.3.0]octane derivative having formula 1 : where X represents -CH 2 -, -O-, -S-, -NR 1 - or -POOR 2 -, Y represents -0-, -0-CO-, -O-CO-O-, -O-CS-S-, -S-, -S-CO-, -O-CO-NH-, -S-CO-NH-, -NH-CO-, -NH-CO-NH-, -O-POOR 2 - or -O-POOR 2 -O-, R represents R 3 or CH 3 CO or, if Y = O, represents -SiR 2 3 , -SiR 2 2 -OR 2 , -{CO-D-CO-O-E-O} n -(CO) P R 3 , or -{CO-E-O} n -(CO) p R 3 , R 1 represents C r C 4 alkyl or C,-C 4 alkanoyl, R 2 represents C,-C 4 alkyl, R 3 represents C 2 -C 18 alkyl, C 2 -C 18 alkenyl, C 3 -C 10 cycloalkyl or C 7 -C, 8 aryl- alkyl, where one or more of the methylene groups can be replaced by an oxygen atom, D represents C 2 -C I0 alkylene or C 2 -C 10 alkenylene, E represents C 2 -C 10 alkylene, cycloalkylene or bicycloalkylene, where one or more of the methylene groups can be replaced by an oxygen atom, n is a number from 1 to 20, in particular 1 to 10, and p is 0 or 1, as a plasticiser or solvent for a polymer. 2. Use according to Claim 1 , wherein X represents -O-. 3. Use according to Claim 1 or 2, wherein Y represents -O-CO-. 4. Use according to any one of Claims 1-3, wherein R represents C 3 -C 10 alkyl or C 3 -C, 0 alkenyl. 1 1 5. Use according to any one of Claims 1-4, wherein 1-900 parts by weight, in particular 10-80 parts by weight, of the bicyclooctane derivative are used per 100 parts of synthetic polymer to be plasticised. 6. Use according to any one of Claims 1-5, wherein a dialkyl phthalate, adipate or sebacate, or trialkyl trimellitate, phosphate, citrate and/or a polyester are also used. 7. Use according to any one of Claims 1-6, wherein said polymer is PVC. 8. Use according to any one of Claims 1-6, wherein said polymer is a rubber. 9. Use according to any one of Claims 1-6, for plasticising coatings or adhesives. 10. Use according to any one of Claims 1-6, for plasticising an ink. 11. Use according to any one of Claims 1-6, for plasticising a sealant. 12. Use according to any one of Claims 1-6, for plasticising a polymer foam. 13. Bicyclo[3.3.0]octane derivative of formula 1, in which: X represents -CH 2 -, -O-, -S-, -NR'- or -POOR 2 -, Y represents -O-CO- or -O-CO-O-, -O-POOR 2 - or -O-POOR 2 -O-, and R represents C 3 -C w alkyl or C 3 -C 10 alkenyl. 14. Bicyclo[3.3.0]octane derivative according to Claim 7, which is a dianhydro- hexitol diester having formula 1 in which: X represents -O-, Y represents -O-CO- and R represents C 4 -C 8 alkyl. 15. Mixture of plasticisers which comprises 20-90 wt% of a bicyclo[3.3.0]octane derivative s defined in any one of Claims 1-6 and 10-80 wt% of a dialkyl phthalate, adipate, sebacate, or a trialkyl trimellitate, phosphate, citrate, an alkyl benzoate and/or a polyester. AMENDED CLAIMS [received by the International Bureau on 23 August 1999! (23.08.99); original claims 1-15 replaced by new claims 1-11 (2 pages)] 1. Use of a bicyclop ,3 ,0]octane derivative having formula 1 : CO-R wherein R represents C5-C11 alkyl or alkenyl, as a plasticiser or solvent for a polymer. 2. Use according to Claim 1, wherein 1-900 parts by weiglώ, in particular 10-80 parts by weight, of the bicyclooctane derivative are used per 100 parts of synthetic polymer to be plasticised. 3. Use according to Claim 1 or 2, wherein a dialkyl phthalate, adipate or sebacate, or trialkyl trimellitate, phosphate, citrate and/or a polyester are also used 4. Use according to any one of Claims 1-3, wherein said polymer is PVC. 5. Use according to any one of Claims 1-3, wherein said polymer is a rubber. 6. Use according to any one of Claims 1-3, for plasticising coatings or adhesives. 7. Use according to any one of Claims 1 -3, for plasticising an ink. 8. Use according to any one of Claims 1-3, for plastiάsi-og a sealant. 9. Use according to .any one of Claims 1-3, for plasticising a polymer foam. 13 10. Bicyclo[3.3,0]octane derivative of formula 1, in which: R represents Cs-Cπ alkyl or Cs-Cn alkenyl. 11. Mbcture of plasticisers which comprises 20-90 wt% of a bicyclo[3.3.Q]octane derivative as defined in Claim 10 and 10-80 wt% of a dialkyl phthalate, adipate, sebacate, or a trialkyl trimellitate, phosphate, trate, an alkyl benzoate and/or a polyester,

Inventors: JANSEN JOHANNES CAROLUS, LUITJES HENDRIKUS, JANSEN, JOHANNES, CAROLUS, LUITJES, HENDRIKUS
Applicants: INST VOOR AGROTECH ONDERZOEK, JANSEN JOHANNES CAROLUS, LUITJES HENDRIKUS, INSTITUUT VOOR AGROTECHNOLOGISCH ONDERZOEK (ATO-DLO), JANSEN, JOHANNES, CAROLUS, LUITJES, HENDRIKUS
Application year: 1999
Main classification: C08K5
IPC codes: C07D487, C07D493, C08K5