PESTICIDAL COMPOSITIONS

Abstract: Pesticidal compositions in form of acqueous suspoemulsions, comprising at least two pesticides which are substantially insoluble in water, wherein one pesticide A is solid and the other pesticide B is liquid or is dissolved in a hydrophobic organic solvent, and a combination of surfactants comprising (1) a tristyrylphenol-ethoxylate having 6-14 mol ethoxylate, in nonionic form, and (2) a tristyrylphenol-ethoxylate having 14-18 mol ethoxylate in form of its sulfate or phosphate, in anionic or acid form, and (3) a dialkyl-sulfosuccinate salt.

Description: Pesticidal Compositions The present invention relates to pesticidal compositions in form of aqueous suspoemulsions, comprising at least two pesticides which are substantially insoluble in water, wherein one pesticide A is solid and the other pesticide B is liquid or is dissolved in a hydrophobic organic solvent, and a combination of surfactants comprising (1 ) a tristyrylphenol-ethoxylate having 6-14 mol ethoxylate, in nonionic form, and (2) a tristyrylphenol-ethoxylate having 14-18 mol ethoxylate in form of its sulfate or phosphate, in anionic or acid form, and (3) a dialkyl-sulfosuccinate salt. Suspoemulsions according to the invention consist of at least three phases: an aqueous phase, comprising pesticide A in solid dispersed form, and an organic phase comprising pesticide B, either in liquid form or dissolved in an organic hydrophobic solvent. Normally the aqueous phase is the continuous phase. Such suspoemulsions are very sensible systems regarding physical and chemical stability. Suspoemulsions comprising pesticides are described for example in EP 88,049, EP 143,099 and EP 261 ,492. However, the known suspoemulsions do not always satisfy the needs of agricultural practice in many incidents and aspects: some suspoemulsions are not suitable for certain pesticide combination due to lacking stability. For example, they become inhomogeneous on storage, pH or viscosity are not remaining constant, particle size is growing which may plug the nozzle of the spray device, or the active ingredient may decompose. As a result the handling is rendered difficult and the biological efficacy is reduced. Furtheron, some of the surfactants used in the known suspoemulsions, as alkylphenol ethoxylates, for example nonylphenol ethoxylates, are not entirely satisfactory with respect to their ecological and toxicological properties, and their replacement is desirable. The suspoemulsions provided herewith are storage stable, easy to apply, ecological and toxicological favourable and have good pesticidal efficacy. The compositions according to the invention are stable for at least 12 months at 25°C. Suitable salts of the surfactants are, for example, metal salts, such as alkali metal or alkaline earth metal salts, for example sodium, potassium calcium or magnesium salts, or salts with ammonia or an organic amine, such as morpholine, piperidine, pyrrolidine, a mono-, di- or tri-lower alkylamine, for example ethyl-, diethyl-, triethyl- or dimethyl- propylamine, or a mono-, di- or tri-hydroxy-lower alkylamine, for example mono-, di- or tri- ethanolamine. Preferred combinations of surfactants are (1 ) a tristyrylphenol-ethoxylate having 8-12, preferably 10 mol ethoxylate, and (2) a tristyrylphenol-ethoxylate having 16 mol ethoxylate, in form of its sulfate or phosphate, preferably in form of its ammonuim sulfate, and (3) a dioctyl-sulfosuccinate salt, preferably the sodium salt. Pesticides which are substantially insoluble in water means their solubility at room temperature is less than 2%, preferably less than 0.2%. Liquid means the melting point is below 30°C. The term pesticide is understood to encompass herbicides, insecticides, acaricides, nemati- cides, ectoparasiticides, fungicides and plant growth regulators; many of them are described in The Pesticide Manual, 11th Ed, British Crop Protection Council. Preference is given to herbicides. Suitable herbicides A, which are solid and substantially insoluble water are for example triazine derivatives, as atrazine, terbutryn, prometryn, terbuthylazine, ametryn, cyanazine, desmetrine, propazine, simazine, simetryn, terbumeton; preferred ar atrazine, terbutryn, prometryn, and terbuthylazine; or urea derivatives, as isoproturon, chlorobromuron, chlorotoluron, diuron, metobromuron, metoxuron. Suitable herbicides B, which are liquid or soluble in a hydrophobic organic solvent, are acetanilide derivatives, as alachlor, metolachlor or S-metolachlor (S-enantiomer of racemic metolachlor); preferred are metolachlor and S-metolachlor. Particularly preferred are the combinations atrazine/metolachlor and atrazine/S-metolachlor. It may be advantageous to combine the herbicides with a safener, for example with benoxacor. Suitable fungicides A are for example sulfur, copperhydroxide, mancozeb, folpet, chlorthalonil, carbendazim, acibenzolar-S-methyl. Suitable fungicides B are for example benomyl, cyprodinil, dimethomorph, edifenphos, fenpropimorph, metaiaxyl, (R)-metalaxyl (enantiomer), oxadixyl, pyrifenox, thiabendazol, - 3 - tridemorph, azoxystrobin, kresoxim-methyl or triazoles such as propiconazol, difenoconazol, bromoconazol, cyproconazole, epoxyconazol, hexaconazol, ipconazol, fenbuconazol, myclobutanil, penconazol, tebuconazol, triadimefon, triadimenol, tetraconazol, triticonazol, or uniconazol; furtheron famoxadone, quinoxyfen, spiroxamin, fludioxonil, fenpiclonil, fenhexamid and 2-[α-{[(α-methyl-3-trifluoromethyl-benzyl)imino]- oxy}-o-tolyl] -glyoxylic acid-methylester-O-methyloxim. Suitable insecticides/acaricides are benthiocarb, diflubenzuron, teflubenzuron, lufenuron, diafenthiuron or pyrethroide such as bifenthrin, bioallethrin, tau-fluvalinate, resmethrin, permethrin, cypermethrin, cyfluthrin, cyhalothrin, deltamethrin, tefluthrin or tetramethrin; furtheron pymetrozin, thiocyclam, fenoxycarb, methopren, abamectin and emamectin. Suitable hydrophobic organic solvents in which the pesticides may be dissolved are aliphatic and aromatic hydrocarbons such as hexane, cyclohexane, benzene, toluene, xylene, mineral oil or kerosin, mixtures or substituted naphthalenes, mixtures of mono- and polyalkylated aromatics, halogenated hydroarbons such as methylene chloride, chloroform and o-dichlorobenzene; phthalates, such as dibutyl phthalate or dioctyl phthalate; ethers and esters, such as ethylene glycol monomethyl or monoethyl ether, fatty acid esters; pyrrolinones, such as N-octylpyrrolidone, ketones, such as cyclohexanone; plant oils such as castor oil, soybean oil, cottonseed oil and possible methyl esters thereof; as well as epoxidised coconut oil or soybean oil. The amount of organic solvent is not critical and can vary from 0 to 50%, depending on the solubility of the respective pesticide. The average size of the suspended particles is 0.5 to 20, preferably 1 to 5 microns when measured with a laser particle analyzer, e.g a CILAS 920 apparatus. The viscosity of the suspoemulsion is 100 to 2000, preferably 200 to 1500, most preferably 300 to 1000 mPas when measured with a BROOKFIELD viscosymeter with spindle 3 at 30 rpm and 20°C. Suitable concentrations in relation to the composition are (% weight/weight): 1 to 95%, preferably 5 to 90%, more preferably 10 to 80% by weight of pesticides A and B, 3 to 90%, preferably 5 to 80%, more preferably 10 to 60% by weight of water, and 1 to 40%, preferably 2 to 20%, more preferably 4 to 12%, most preferably 6-8% by weight of the surfactants (1 ), (2) and (3) in total. The ratio of the pesticide A : pesticide B is 1 :99 to 99:1 , preferably 1 :5 to 5:1 and 1 :2 to 2:1. The concentration of the surfactants is 0.5 to 20%, preferably 1 to 10%, more preferably 1 to 5% by weight of surfactant (1 ) 0.2 to 15%, preferably 0.5 to 10%, more preferably 1 to 5% by weight of surfactant (2) 0.2 to 20%, preferably 0.5 to 15%, more preferably 1 to 5% by weight of surfactant (3). The composition according to the invention may comprise additional dispersants and adjuvants, as (in % by weight) a dispersing agent, 0 to 20%, preferably 0.2 to 5%, e.g. fatty alcohole ethers, fatty acid esters, arylsuifonates as polynaphtalensulfonate, alkylarylsulfonates as dodecylbenzene sulfonate, alkylsulfonates as sodium suifosuccinate, polyalkyleneglycol ethers, acrylic Graft Co-Polymer, N-methly-N-oleyl-taurin Na salt or polyvinylalkohol, preferably 0.2 to 5% dodecylbenzene sulfonate calcium; a thickening agent, 0 to 2%, preferably 0J to 1 %, e.g. xanthan gum, heteropolysaccharides, oxypropylated cellulose, precipitated or fused silica (hydrophobizised or non-hydrophobizised), gelatine, polysaccharides, tetramethyl decyne diol, ethoxylated dialkyi phenol, methylated clay, propylene carbonate, hydrogenated castor oil, ethoxylated vegetable oil, sodium benzoate or hexanediol; an antifreeze agent, 0 to 20%, preferably 1 to 10% , e.g. 1 ,2-propyleneglycol, glycerine, ethyleneglycol or freezing point-lowering salts; a defoaming agent, 0 to 5%, preferably 0J to 2%, e.g. silicone oil, alcohols, fluoroorganics or mineral oils; a preservative/biocide, 0 to 10%, preferably 0.1 to 3% , e.g. formaldehyde, 1 ,2 benzisothiazol-3(2H)-one or its salts, or benzoic acid; a buffer. 0 to 5%, preferably 0J to 3% , e.g. acetic acid (AcOH)/NaOH or AcOH/KOH, H 3 PO 4 /NaOH or H3PO4/KOH, citric acid/NaOH or citric acid/KOH, or KH 2 PO 4 /Borax; as well as further wetting, dispersing and emulsifying agents, organic solvents, cosotvents and oils. Another object of the invention is a process for preparing a composition as herein described, by grinding or milling the solid pesticide and then intimateley mixing, optionally by warming, the components, until a homogeneous phase is achieved. - 5 In another aspect of the invention the composition is an aqueous spray mixture. Before the application, the composition of the invention may be diluted with water by simple mixing at ambient temperature in order to get a ready for use spray mixture. The resulting spray mixtures are stable, i.e. they remain as a homogeneously dispersed phase on standing without agitation for at least one hour to 12 hours or even more. Preferred concentrations of the spray mixture are 0.05 to 10 %, more preferred 0.2 to 5% pesticide in relation to the spray mixture. A further aspect of the invention is a method of preventing or combatting undesirable plant growth, infestation of plants or animals by pests and regulating plant growth by diluting the composition according to claim 1 with water and applying a pesticidally effective amount to the cultivation area, to the plant or animal. Preparation examples The following Examples illustrate the invention in more detail. The registered trademarks and other designations denote the following products: The suppliers are known or may easily be found, e.g. in "McCutcheon's Emulsifiers and Detergents", Rock Road, Glen Rock, NJ 07452-1700, USA, 1997. SOPROPHOR TS 10 W Tristyrylphenol-10 EO surfactant (1 ) SOPROPHOR TS 8 ® Tristyrylphenol-8 EO (supplier: RHODIA, 25, Quai Paul Doumer F-92408 Courbevoie) SOPROPHOR 4 D 384 Tristyrylphenol-16 EO, ammonium surfactant (2) (RHODIA) sulfate GEROPON DOS/PG* sodium dioctyl suifosuccinate (65% in surfactant (3) (RHODIA) propyieneglycol) ANTIFOAM A (DOW) polymethylsiloxan defoaming agent RHODORSIL 426 and 454 (RHODIA) - 6 PROXEL GXL (ICI) sodium 1 ,2 benzisothiazol-3(2H)-one, preservative/ PROXEL BD (ICI) 1 ,2 benzisothiazol-3(2H)-one biocide RHODOPOL 23 heteropolysaccharides thickener (RHODIA) ATLOX 4913 (ICI) Acryl Craft Copolymer (in water/PG) dispersing agent EO = ethyleneoxid The components are intimately mixed, optionally by warming, until a homogeneous phase is achieved. All the compositions according to the examples are stable for at least 12 months at 25°C. After diluting with water the compositions form ready to use spray mixtures. The numbers given in the Examples are concentrations in % weight/weight. Examples 1 1 a 1 b 1 c 1 d herbicide A Atrazine 17 31 31 31 herbicide B Metolachlor 33 21 21 21 surfactant (1 ) Soprophor TS 10 4.6 4.6 1.5 2.5 surfactant (2) Soprophor 4D384 1.2 1.2 2 2.5 surfactant (3) Geropon DOS/PG 1.2 1.2 4 3 antifreezer 1 ,2 Propylenglycol 5 5 5 2 defoaming agent Rhodorsil 426 0.3 0.3 0.3 0.3 preservative Proxel BD 0.12 0J2 0J2 0J 2 thickener Rhodopol 23 0J2 0.12 0.12 0J2 Water ad 100 ad 100 ad 100 ad 100 Examples 2 2a 2b 2c 2d 2e 2f herbicide A Atrazine 30 30 32 37 32 37 herbicide B S-Metolachlor 28.5 28.5 40 29 40 29 surfactant (1 ) Soprophor TS 10 - 5.4 4.6 3.8 4.6 3.8 surfactant (1 ) Soprophor TS 8 4.6 - - - - - surfactant (2) Soprophor 4D384 1.2 1 1.2 1.4 1.2 1.4 surfactant (3) Geropon DOS/PG 1.2 1.2 1.7 1.2 1.7 1.2 dispersing agent dodecylbenzene 0.5 1 sulfonate calcium antifreezer 1 ,2 Propylenglycol 3 3 5 3 5 3 defoaming agent Antifoam A 0.3 0.3 0.3 0.3 0.3 0.3 preservative Proxel GXL 0.03 0.03 0J2 0.03 0.12 0.03 thickener Rhodopol 23 0.12 0.12 0.12 0.12 0J2 0.12 Water ad 100 ad 100 ad 100 ad 100 ad 100 ad 100 Examples 3 3a 3b 3c herbicide A Terbutryn 20 20 20 herbicide B S-Metolachlor 25 25 25 surfactant (1) Soprophor TS 10 4.6 1.5 2.5 surfactant (2) Soprophor 4D384 1.2 1.5 2 surfactant (3) Geropon DOS/PG 1.2 4.5 3.5 antifreezer 1 ,2 Propylenglycol 3 3 3 defoaming agent Antifoam A 0.3 0.3 0.3 preservative Proxel GXL 0.03 0.03 0.03 thickener Rhodopol 23 0.12 0.12 0.12 Water ad 100 ad 100 ad 100 8 - Examples 4 4a 4b 4c 4d herbicide A Prometryn 20 20 20 20 herbicide B S-Metolachlor 12.4 12.4 12.4 12.4 surfactant (1 ) Soprophor TS 10 3.8 4.5 2.5 4 surfactant (2) Soprophor 4D384 1.2 1.5 2 1 surfactant (3) Geropon DOS/PG 1.2 1 2.5 1 dispersing agent Atlox 4913 2 2 2 2 antifreezer 1 ,2 Propylenglycol 3 3 3 3 defoaming agent Antifoam A 0.3 0.3 0.3 0.3 preservative Proxel GXL 0.03 0.03 0.03 0.03 thickener Rhodopol 23 0.12 0J2 0.12 0J2 Water ad 100 ad 100 ad 100 ad 100 Examples 5 5a 5b 5c herbicide A Terbuthylazin 18J 18J 18.7 herbicide B S-Metolachlor 31.3 31.3 31.3 surfactant (1 ) Soprophor TS 10 4.6 1.5 2.5 surfactant (2) Soprophor 4D384 1.2 1.2 2 surfactant (3) Geropon DOS/PG 1.2 4.5 3.5 dispersing agent Atlox 4913 2 2 2 antifreezer 1 ,2 Propylenglycol 5 5 5 defoaming agent Antifoam A 0.2 0.2 0.2 preservative Proxel GXL 0.03 0.03 0.03 thickener Rhodopol 23 0J2 0J2 0J2 Water ad 100 ad 100 ad 100 Comparison Examples Without either of the surfactants (1 ), (2) and/or (3) the formulation becomes inhomogeneous after a few weeks or months at 20-25°C.

Claims: - 9 - Claims 1. A pesticidal composition in form of an aqueous suspoemulsion, comprising at least two pesticides A and B which are substantially insoluble in water, wherein pesticide A is solid and pesticide B is liquid or is dissolved in a hydrophobic organic solvent, and a combination of surfactants comprising (1 ) a tristyrylphenol-ethoxylate having 6-14 mol ethoxylate, in nonionic form, and (2) a tristyrylphenol-ethoxylate having 14-18 mol ethoxylate in form of its sulfate or phosphate, in anionic or acid form, and (3) a dialkyl-sulfosuccinate salt. 2. A composition according to claim 1 , wherein the surfactants are (1 ) a tristyrylphenol-ethoxylate having 8-12, preferably 10 mol ethoxylate, and (2) a tristyrylphenol-ethoxylate having 16 mol ethoxylate, in form of its sulfate or phosphate, preferably in form of its ammonium sulfate, and (3) a dioctyl-sulfosuccinate salt, preferably the sodium salt. 3. A composition according to claim 1 , comprising 1 to 95% by weight of pesticides A and B, 3 to 90% by weight of water, 1 to 40% by weight of surfactants (1 ), (2) and (3). 4. A composition according to claim 1 , wherein the ratio of the pesticide A : pesticide B is 1 :99 to 99:1. 5. A composition according to claim 1 , wherein the concentration of the surfactants is 0.5 to 20% of surfactant (1 ), 0.2 to 15% of surfactant (2), 0.2 to 20% of surfactant (3). 6. A composition according to claim 1 , wherein the pesticides are herbicides. - 10 - 7. A composition according to claim 6, wherein the herbicide A is a triazine or an urea derivative, and the herbicide B is an acetanilide derivative. 8. A composition according to claim 7, wherein the triazine herbicide A is selected from atrazine, terbutryn, prometryn and terbuthylazine, and wherein the acetanilide herbicide B is selected from metolachlor and S-metolachlor (enantiomer). 9. A composition according to claim 8, comprising the combinations atrazine/metolachlor and atrazine/S-metolachlor. 10. A method of preventing or combatting undesirable plant growth, infestation of plants or animals by pests and regulating plant growth by diluting the composition according to claim 1 with water and applying a pesticidally effective amount to the cultivation area, to the plant or animal.

Inventors: GUBELMANN-BONNEAU ISABELLE, PFAMMATTER FREDDY, SCHLATTER CHRISTIAN, VOGT MANFRED, GUBELMANN-BONNEAU, ISABELLE, PFAMMATTER, FREDDY, SCHLATTER, CHRISTIAN, VOGT, MANFRED
Applicants: GUBELMANN BONNEAU ISABELLE, NOVARTIS AG, NOVARTIS ERFIND VERWALT GMBH, PFAMMATTER FREDDY, SCHLATTER CHRISTIAN, VOGT MANFRED, GUBELMANN-BONNEAU, ISABELLE, NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H., PFAMMATTER, FREDDY, SCHLATTER, CHRISTIAN, VOGT, MANFRED
Application year: 1999
Main classification: A01N25
IPC codes: A01N25, A01N37, A01N43, A01N47, A01P7, A01P13, A01P21