SUBSTITUTED QUINOXALIN-2(1H)-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS

Abstract: The present invention relates to quinoxalin-2(1H)-ones of formula (I) or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same and methods of using the same for treating viral infection or as an assay standard or reagent.

Description: TITLE SUBSTITUTED QU NOXALIN-2 (IH) -ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS FIELD OF THE INVENTION This invention relates generally to substituted quinoxalin-2 (IH) -ones which are useful as inhibitors of HIV reverse transcriptase, pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as assay standards or reagents . BACKGROUND OF THE INVENTION Two distinct retroviruses, human immunodeficiency virus (HIV) type-1 (HIV-1) or type-2 (HIV-2), have been etiologically linked to the immunosuppressive disease, acquired immunodeficiency syndrome (AIDS) . HIV seropositive individuals are initially asymptomatic but typically develop AIDS related complex (ARC) followed by AIDS. Affected individuals exhibit severe immunosuppression which predisposes them to debilitating and ultimately fatal opportunistic infections . The disease AIDS is the end result of an HIV-1 or HIV-2 virus following its own complex life cycle. The virion life cycle begins with the virion attaching itself to the host human T-4 lymphocyte immune cell through the bonding of a glycoprotein on the surface of the virion 's protective coat with the CD4 glycoprotein on the lymphocyte cell . Once attached, the virion sheds its glycoprotein coat, penetrates into the membrane of the host cell, and uncoats its RNA. The virion enzyme, reverse transcriptase, directs the process of transcribing the RNA into single-stranded DNA. The viral RNA is degraded and a second DNA strand is created. The now double-stranded DNA is integrated into the human cell's genes and those genes are used for virus reproduction. At this point, RNA polymerase transcribes the integrated DNA into viral RNA. The viral RNA is translated into the precursor gag-pol fusion polyprotein. The polyprotein is then cleaved by the HIV protease enzyme to yield the mature viral proteins. Thus, HIV protease is responsible for regulating a cascade of cleavage events that lead to the virus particle's maturing into a virus that is capable of full infectivity. The typical human immune system response, killing the invading virion, is taxed because the virus infects and kills the immune system's T cells. In addition, viral reverse transcriptase, the enzyme used in making a new virion particle, is not very specific, and causes transcription mistakes that result in continually changed glycoproteins on the surface of the viral protective coat. This lack of specificity decreases the immune system's effectiveness because antibodies specifically produced against one glycoprotein may be useless against another, hence reducing the number of antibodies available to fight the virus. The virus continues to reproduce while the immune response system continues to weaken. Eventually, the HIV largely holds free reign over the body's immune system, allowing opportunistic infections to set in and without the administration of antiviral agents, immunomodulators , or both, death may result. There are at least three critical points in the virus ' s life cycle which have been identified as possible targets for antiviral drugs: (1) the initial attachment of the virion to the T-4 lymphocyte or macrophage site, (2) the transcription of viral RNA to viral DNA (reverse transcriptase, RT) , and (3) the processing of gag-pol protein by HIV protease. Inhibition of the virus at the second critical point, the viral RNA to viral DNA transcription process, has provided a number of the current therapies used in treating AIDS . This transcription must occur for the virion to reproduce because the virion 's genes are encoded in RNA and the host cell reads only DNA. By introducing drugs that block the reverse transcriptase from completing the formation of viral DNA, HIV-1 replication can be stopped. A number of compounds that interfere with viral replication have been developed to treat AIDS. For example, nucleoside analogs, such as 3 ' -azido-3 ' -deoxythymidine (AZT), 2 * , 3 ' -dideoxycytidine (ddC) , 2 ' , 3 ' -dideoxythymidinene (d4T) , 2 ' ,3 ' -dideoxyinosine (ddl) , and 2 ' , 3 ' -dideoxy-3 ' -thia- cytidine (3TC) have been shown to be relatively effective in halting HIV replication at the reverse transcriptase (RT) stage. Non-nucleoside HIV reverse transcriptase inhibitors have also been discovered. As an example, it has been found that certain benzoxazinones are useful in the inhibition of HIV reverse transcriptase, the prevention or treatment of infection by HIV and the treatment of AIDS. U. S. Patent Number 5,519,021, the contents of which are hereby incorporated herein by reference, describes reverse transcriptase inhibitors which are benzoxazinones of the formula : wherein X is a halogen, Z may be O. However, benzoxazinones are not part of the present invention. U.S. Patent No. 5,693,641 depicts bicyclic pyrimidine derivatives useful as anticoagulants of the formula: wherein Z 1 and Z 2 , independently, can be -0-, -NR 5 -, or -OCH 2 -; R 5 is H, alkyl, aryl, or aralkyl; R 6 and R 7 can be a variety of groups . Compounds of this sort are not within the scope of the presently claimed invention. EP 0,657,166 Al illustrates quinoxalines of the formula: which in combination with at least one nucleoside exhibit an antiviral effect. The application describes quinoxalines generally, wherein X is 0 or S; R 2 or R 5 can be a variety of groups including H, alkyl, alkenyl, alkynyl, cycloalkyl, substituted carbonyl, substituted oxycarbonyl, substituted aminocarbonyl ; and R 3 or R 4 , can be a variety of groups including H, alkyl, alkenyl, cycloalkyl, and aryl, but not alkynyl. However, EP 0,657,166 Al does not disclose by exemplification compounds wherein R 3 or R 4 are -CF 3 , -CF 2 CF 3 , -CF 2 CF 2 CF 3 or cyclopropyl, compounds wherein R 3 or R 4 are alkynyls or substituted alkynyls . Even with the current success of reverse transcriptase inhibitors, it has been found that HIV patients can become resistant to a single inhibitor. Thus, it is desirable to develop additional inhibitors to further combat HIV infection. It has unexpectedly been found that compounds of the present invention, most preferably, 3- (perfluoroalkyl) -3 , 4- dihydro-l,H-quinoxalin-2-ones, are useful as HIV reverse transcriptase inhibitors . SUMMARY OF THE INVENTION Accordingly, one object of the present invention is to provide novel reverse transcriptase inhibitors. It is another object of the present invention to provide a novel method for treating HIV infection which comprises administering to a host in need of such treatment a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt or prodrug form thereof. It is another object of the present invention to provide a novel method for treating HIV infection which comprises administering to a host in need thereof a therapeutically effective combination of (a) one of the compounds of the present invention and (b) one or more compounds selected form the group consisting of HIV reverse transcriptase inhibitors and HIV protease inhibitors . It is another object of the present invention to provide pharmaceutical compositions with reverse transcriptase inhibiting activity comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt or prodrug form thereof. It is another object of the present invention to provide a method of inhibiting HIV present in a body fluid sample which comprises treating the body fluid sample with an effective amount of a compound of the present invention. It is another object of the present invention to provide a kit or container containing at least one of the compounds of the present invention in an amount effective for use as a standard or reagent in a test or assay for determining the ability of a potential pharmaceutical to inhibit HIV reverse transcriptase, HIV growth, or both. These and other objects, which will become apparent during the following detailed description, have been achieved by the inventors' discovery that compounds of formula (I): (I) wherein A, W, X, Y, Z, R^-, R2, and C f are defined below, stereoisomeric forms, mixtures of stereoisomeric forms, or pharmaceutically acceptable salt forms thereof, are effective reverse transcriptase inhibitors . DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS Thus, in a first embodiment, the present invention provides a novel compound of Formula (I) : (I) or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein: A is 0 or S; W is N or CR 3 ; X is N or CR 4 ; Y is N or CR 5 ; Z is N or CR 6 ; C f is cyclopropyl or Cι_ 3 alkyl substituted with 3-7 halogen; provided that the number of W, X, Y, and Z which are N, is zero, one or two; R 1 is selected from: -C0 2 R 12 , -COR 12 , -S0 2 R 12 , -SOR 12 , -CONHR 12 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , -Ci- 6 alkyl substituted with 0-3 R 11 , - (CH 2 ) p phenyl substituted with 0-3 R 10 , and -(CH 2 ) p (C 3 - 5 cycloalkyl); R 2 is selected from: -CH=CR 7 R 8 , -C≡C-R 8 , -CH=CHCHR 7 R 8 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , -Cι_ 4 alkyl substituted with 0-3 R 11 , - (CH 2 ) p phenyl substituted with 0-3 R 10 , and -(CH 2 ) p (C 3 - 5 cycloalkyl); R 3 is selected from: H, F, CI, Br, I, -OH, OCF 3 , -CN, N0 2 , CHO, C(=0)CH 3 , C(=0)CF 3/ C(=0)NH 2 , C(=0)NHCH 3 , NR 7 R 7a , NR 7 C(=0)OR 7b , C(=0)OR 7 , SR 7 , S(=0)R 7 , S0R 7 , S0 2 NHR 7 , NR 7 S0 2 R 7b , Cι- 3 alkyl substituted with 0-3 R 11 , C 2 - 3 alkenyl, C 2 - 3 alkynyl, Cι_ 3 alkoxy, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R 10 ; R 4 is selected from: H, F, CI, Br, I, -OH, OCF 3 , -CN, N0 2 , CHO, C(=0)CH 3 , C(=0)CF 3 , C(=0)NH 2 , C(=0)NHCH 3 , NR 7 R 7a , NR 7 C(=0)OR 7b , C(=0)OR 7 , SR 7 , S(=0)R 7 , S0 2 R 7 , S0 2 NHR 7 , NR 7 S0 2 R 7b , C 1 - 3 alkyl substituted with 0-3 R 11 , C 2 - 3 alkenyl, C 2 - 3 alkynyl, Cχ- 3 alkoxy, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R 10 ; alternatively, R 3 and R 4 , when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form a 5-7 membered carbocyclic ring, said carbocyclic ring being aromatic or nonaromatic, said carbocyclic ring being substituted with 0-2 R 10 ; alternatively, R 3 and R 4 , when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form a 5-7 membered heterocyclic ring containing 1, 2 or 3 heteroatoms atoms selected from the group consisting of N, O, and S, said heterocyclic ring being aromatic or nonaromatic, said heterocyclic ring being substituted with 0-2 R 10 ; R 5 is selected from H, F, CI, Br, I, -OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy; alternatively, R 4 and R 5 , when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form a 5-7 membered carbocyclic ring, said carbocyclic ring being aromatic or nonaromatic, said carbocyclic ring being substituted with 0-2 R 10 ; alternatively, R 4 and R 5 , when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form a 5-7 membered heterocyclic ring containing 1, 2 or 3 heteroatoms atoms selected from the group consisting of N, O, and S, said heterocyclic ring being aromatic or nonaromatic, said heterocyclic ring being substituted with 0-2 R 10 ; R 6 is selected from: H, OH, F, CI, Br, I, OCF 3 , -CN, N0 2 , CHO, C(=0)CH 3 , C(=0)CF 3 , C(=0)NH 2 , C(=0)NHCH 3 , NR 7 R 7 , NR 7 C(=O)0R 7b , C(=0)0R 7 , SR 7 , S(=0)R 7 , S0 2 R 7 , S0 2 NHR 7 , NR 7 S0 2 R 7b , Cι_ 3 alkyl substituted with 0-3 R 11 , C 2 - 3 alkenyl, C 2 - 3 alkynyl, C 1 -. 3 alkoxy, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S and substituted with 0-2 R 10 ; R 7 , at each occurrence, is selected from H, methyl, ethyl, propyl, and butyl; R 7a , at each occurrence, is selected from H, methyl, ethyl, propyl , and butyl; ; R 7b , at each occurrence, is methyl, ethyl, propyl, or butyl; R 8 , at each occurrence, is selected from: H, F, CI, Br, I, CH(-OCH 2 CH 2 0-) , C 1 - 4 haloalkyl, Cι_ 6 alkyl substituted with 0-3 R 11 , C 2 _ 6 alkenyl, C 3 - 7 cycloalkyl substituted with 0-2 R 9 , phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R 10 ; R 9 , at each occurrence, is selected from D, OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, and F; R 10 , at each occurrence, is selected from OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, F, CI, Br, I, CN, NR 7 R 7a , and C(=0)CH 3 ; R 11 , at each occurrence, is selected from OR 7 , CN, F, CI, Br, I, N0 2 , NR 7 R 7a , CHO, C(=0)CH 3 , C(=0)NH 2 ; R 12 , at each occurrence, is selected from Ci- 6 alkyl, C 2 _ 4 alkenyl, C2-4 alkynyl, C 3 - 7 cycloalkyl, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-3 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R 10 , - (CH 2 ) p phenyl substituted with 0-2 R 10 , and - (CH 2 ) p (C 3 - 5 cycloalkyl); and p, at each occurrence, is selected from 0, 1, 2, and 3; provided, if, simultaneously, each of W, X, Y, and Z are carbon, then R 2 is not unsubstituted C 1 - 4 alkyl. In a preferred embodiment, the present invention provides a novel compound of Formula (II) , wherein: (ID wherein: A is 0 or S; C f is -CF 3 , -CF 2 CF 3 , or -CF 2 CF 2 CF 3 ; R 1 is selected from: -C0 2 R 12 , -COR 12 , -S0 2 R 12 , -SOR 12 , -CONHR 12 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p O≡C-R 8 , -Ci- 6 alkyl substituted with 0-3 R 11 , - (CH 2 ) p phenyl substituted with 0-3 R 10 , and -(CH 2 ) p (C 3 _ 5 cycloalkyl); R 2 is selected from: -CH=CR 7 R 8 , -C≡C-R 8 , -CH=CHCHR 7 R 8 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , - (CH 2 ) p phenyl substituted with 0-3 R 10 , and -(CH 2 ) p (C 3 - 5 cycloalkyl); R 3 is selected from: H, F, CI, Br, I, -OH, 0CF 3 , -CN, N0 2 , CHO, C(=0)CH 3 , C(=0)CF 3 , C(=0)NH 2 , C(=0)NHCH 3 , NR 7 R 7a , NR 7 C(=0)0R 7b , C(=0)OR 7 , SR 7 , S(=0)R 7 , S0 2 R 7 , S0 2 NHR 7 , NR 7 S0 2 R 7b , Cι- 3 alkyl substituted with 0-3 R 11 , C 2 _ 3 alkenyl, C 2 _ 3 alkynyl, Cι- 3 alkoxy, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S and substituted with 0-2 R 10 ; R 4 is selected from: H, F, CI, Br, I, -OH, OCF 3 , -CN, N0 2 , CHO, C(=0)CH 3 , C(=0)CF 3 , C(=0)NH 2 , C(=0)NHCH 3 , NR 7 R 7a , NR 7 C(=0)0R 7b , C(=0)OR 7 , SR 7 , S(=0)R 7 , S0 2 R 7 , S0 2 NHR 7 , NR 7 S0 2 R 7b , Cι_ 3 alkyl substituted with 0-3 R 11 , C 2 _ 3 alkenyl, C 2 - 3 alkynyl, C 1 - 3 alkoxy, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R 10 ; alternatively, R 3 and R 4 , when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form -0-CH 2 -0-, -0-CH 2 -CH 2 -0-, or -CH=CH-CH=CH- ; R 5 is selected from H, F, Cl, Br, I, -OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy; alternatively, R 4 and R 5 , when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form -0-CH 2 -0-, -0-CH 2 -CH 2 -0-, or -CH=CH-CH=CH- ; R 6 is selected from: H, OH, F, Cl, Br, I, OCF 3 , -CN, N0 2 , CHO, C(=0)CH 3 , C(=0)CF 3/ C(=0)NH 2 , C(=0)NHCH 3 , NR 7 R 7 , NR 7 C(=0)OR 7b , C(=0)OR 7 , SR 7 , S(=0)R 7 , S0 2 R 7 , S0 2 NHR 7 , NR 7 S0 2 R 7b , C 1 - 3 alkyl substituted with 0-3 R 11 , C 2 - 3 alkenyl, C 2 - 3 alkynyl, C 1 - 3 alkoxy, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R 10 ; R 7 , at each occurrence, is selected from H, methyl, ethyl, propyl, and butyl; R 7a , at each occurrence, is selected from H, methyl, ethyl, propyl , and butyl,- ; R 7b , at each occurrence, is methyl, ethyl, propyl, or butyl; R 8 , at each occurrence, is selected from: H, F, Cl, Br, I, CH(-OCH 2 CH 2 0-) , Cι_ 4 haloalkyl, Ci- 6 alkyl substituted with 0-3 R 11 , C 2 - 6 alkenyl, C 3 - 7 cycloalkyl substituted with 0-2 R 9 , phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R 10 ; R 9 , at each occurrence, is selected from D, OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, and F; R 10 , at each occurrence, is selected from OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, F, Cl, Br, I, CN, NR 7 R 7a , and C(=0)CH 3 ; R 11 , at each occurrence, is selected from OR 7 , CN, F, Cl, Br, I, N0 2 , NR 7 R 7a , CHO, C(=0)CH 3 , C(=0)NH 2 ; R 12 , at each occurrence, is selected from Ci- 6 alkyl, C _ 4 alkenyl, C 2 -4 alkynyl, C 3 -. 7 cycloalkyl, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-3 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R 10 , - (CH 2 ) p phenyl substituted with 0-2 R 10 , and - (CH 2 ) p (C 3 _ 5 cycloalkyl); and p, at each occurrence, is selected from 0, 1, 2, and 3. In a further preferred embodiment, the present invention provides a novel compound of Formula (II) , wherein: A is 0 or S ; C f is -CF 3 , -CF 2 CF 3 , or -CF 2 CF 2 CF 3 ; R 1 is selected from: -C0 2 R 12 , -COR 12 , -S0 2 R 12 , -SOR 12 , -CONHR 12 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , -C 1 - 5 alkyl substituted with 0-3 R 11 , -(CH 2 ) p phenyl substituted with 0-3 R 10 , and -(CH 2 ) p (C 3 - 5 cycloalkyl); R 2 is selected from: -CH=CR 7 R 8 , -C≡C-R 8 , -CH=CHCHR 7 R 8 , -(CHR 7 ) p CHR 7 R 8 , - (CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , -(CH 2 ) p phenyl substituted with 0-3 R 10 , and -(CH 2 ) p (C 3 - 5 cycloalkyl); R 3 is selected from: H, F, Cl, Br, I, -OH, -OCF 3 , -CN, -N0 2 , -CHO, -C(=0)CH 3 , -C(=0)CF 3 , -C(=0)NH 2 , -C(=0)NHCH 3 , -NH 2 , -NHCH 3 , -N(CH ) 2 , -NHC(=0)0CH 3 , -C(=0)0CH 3 , -SCH 3 , -S(=0)CH 3 , -S0 2 CH 3 , -SO 2 NHCH 3 , -NHS0 2 CH 3 , C 1 - 3 alkyl substituted with 0-3 R 11 , C 2 _ 3 alkenyl, C _ 3 alkynyl, C 1 - 3 alkoxy, R 4 is selected from: H, F, Cl, Br, I, -OH, OH, -0CF 3 , -CN, -N0 2 , -CHO, -C(=0)CH 3 , -C(=0)CF 3 , -C(=0)NH 2 , -C(=0)NHCH 3 , -NH 2 , -NHCH3, -NHCH 2 CH 3 , -N(CH 3 ) 2 , -N(CH 2 CH 3 ) 2 , -NHC(=0)0CH 3 , -NHC(=0)0CH 2 CH 3 , -C(=0)0CH 3 , -C(=0)OCH 2 CH 3 , -SCH 3 , -SCH 2 CH 3 , -S(=0)CH 3 , -S(=0)CH 2 CH 3 , -S0 2 H, -SO 2 CH 3 , -S0 2 CH 2 CH 3 , -S0 2 NHCH 3 , -SO 2 NHCH 2 CH 3 , -NHS0 2 CH 3 , -NHS0 2 CH 2 CH 3 , Cι_ 3 alkyl substituted with 0-3 R 11 , C 2 - 3 alkenyl, C 2 - 3 alkynyl, C 1 -. 3 alkoxy, alternatively, R 3 and R 4 , when substituents on adjacent carbon atoms , are taken together with the carbon atoms to which they are attached to form -0-CH -0-, -0-CH -CH 2 -0-, or -CH=CH-CH=CH- ; R 5 is selected from H, F, Cl, Br, I, -OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy; alternatively, R 4 and R 5 , when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form -0-CH -0-, -0-CH 2 -CH 2 -0-, or -CH=CH-CH=CH- ; R 6 is selected from: H, F, Cl, Br, I, -OH, -OCF 3 , -CN, -N0 2 , -CHO, -C(=0)CH 3 , -C(=0)CF 3 , -C(=0)NH 2 , -C(=0)NHCH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHC(=0)OCH 3 , -C(=0)0CH 3 , -SCH 3 , -S(=0)CH 3 , -SO 2 CH 3 , -SO 2 NHCH 3 , -NHSO 2 CH 3 , C 1 - 3 alkyl substituted with 0-3 R 11 , C 2 _ 3 alkenyl, C 2 _ 3 alkynyl, C 1 - 3 alkoxy, R 7 , at each occurrence, is selected from H, methyl, ethyl, propyl, and butyl; R 7a , at each occurrence, is selected from H, methyl, ethyl, propyl , and butyl ; ; R 8 , at each occurrence, is selected from: H, F, Cl, Br, I, CH(-OCH 2 CH 2 0-) , Cι- 4 haloalkyl, Ci- 6 alkyl substituted with 0-3 R 11 , C 2 - 6 alkenyl, C 3 - 7 cycloalkyl substituted with 0-2 R 9 , phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-3 heteroatoms selected from the group consisting of N, O, and S and substituted with 0-2 R 10 ; R 9 , at each occurrence, is selected from D, OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, and F; R 10 , at each occurrence, is selected from OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, F, Cl, Br, I, CN, NR 7 R 7a , and C(=0)CH 3 ; R 11 , at each occurrence, is selected from OR 7 , CN, F, Cl, Br, I, N0 2 , NR 7 R 7a , CHO, C(=0)CH 3 , C(=0)NH 2 ; R 12 , at each occurrence, is selected from Ci- 6 alkyl, C 2 - 4 alkenyl, C _ 4 alkynyl, C 3 - 7 cycloalkyl, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-3 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R 10 , - (CH 2 ) p phenyl substituted with 0-2 R 10 , and -(CH 2 ) p (C 3 -5 cycloalkyl); and p, at each occurrence, is selected from 0, 1, 2, and 3. In a more further preferred embodiment, the present invention provides a novel compound of Formula (II) , wherein: A is 0; C f is -CF 3 or -CF 2 CF 3 ; R 1 is selected from: -C0 2 R 12 , -COR 12 , -S0 2 R 12 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , -Ci- 5 alkyl substituted with 0-3 R 11 , - (CH 2 ) p phenyl substituted with 0-3 R 10 , and -(CH 2 ) p (C 3 -5 cycloalkyl); R 2 is selected from: -CH=CR 7 R 8 , -C≡C-R 8 , -CH=CHCHR 7 R 8 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , - (CH 2 ) p phenyl substituted with 0-3 R 10 , and -(CH 2 ) p (C -5 cycloalkyl); R 3 is selected from: H, F, Cl, Br, I, -OH, -OCF 3 , -CN, -N0 2 , -CHO, -C(=0)CH 3 , -C(=0)CF 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -CF 3 , -CH 3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 , R 4 is selected from: H, F, Cl, Br, I, -OH, OH, -OCF 3 , -CN, -N0 2 , -CHO, -C(=0)CH 3 , -C(=0)CF 3/ -C(=0)NH 2 -C(=0)NHCH 3 , -NH 2 , -NHCH 3/ -N(CH 3 ) 2 , -NHC(=0)0CH 3 , -C(=0)0CH 3 , -CF 3 , -CH 3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 ; R 5 is selected from H, F, Cl, Br, I, -OH, -CH 3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 ; R 6 is selected from: H, F, C , Br, I, -OH, -OCF3 , -CN, -N0 2 , -CHO, -C(=0)CH 3 , -C(=0)CF 3 , -NH 2 , -NHCH3, -N(CH 3 ) 2 , -CF3, -CH3 , -CH 2 CH 3 , -OCH3, and -OCH2CH3; R 7 , at each occurrence, is selected from H, methyl, ethyl, propyl, and butyl; R 8 , at each occurrence, is selected from: H, F, Cl, Br, I, CH (-OCH 2 CH 2 0-) , C 1 - 4 haloalkyl, C 1 - 4 alkyl substituted with 0-3 R 11 , C 2 _ 4 alkenyl, C 3 - 6 cycloalkyl substituted with 0-2 R 9 , phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-3 heteroatoms selected from the group consisting of pyridinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, i idazolyl, and oxazolidinyl; R 9 , at each occurrence, is selected from D, OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, and F; R 10 , at each occurrence, is selected from OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, F, Cl, Br, I, CN, -NH 2 , -NHCH3, -NHCH 2 CH , -N(CH 3 ) 2 , -N(CH 2 CH 3 ) 2 , and C(=0)CH ; R 11 , at each occurrence, is selected from OR 7 , CN, F, Cl, Br, I, N0 2 , -NH 2 , -NHCH 3 , -NHCH 2 CH 3 , -N(CH 3 ) 2 , -N(CH 2 CH 3 ) 2 , CHO, C(=0)CH 3 , C(=0)NH 2 ; R 12 , at each occurrence, is selected from Ci-6 alkyl, C 2 _ 4 alkenyl, C 2 - 4 alkynyl, C 3 - 6 cycloalkyl, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-3 heteroatoms selected from the group consisting pyridinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, and oxazolidinyl, - (CH 2 ) p phenyl substituted with 0-2 R 10 , and -(CH 2 ) p (C 3 - 5 cycloalkyl); and p, at each occurrence, is selected from 0, 1, and 2. In an even more further preferred embodiment, the present invention provides a novel compound of Formula (III) ; wherein: R 1 is selected from: -CF 3 , -CF 2 H, -CH 3 , -CH 2 CH 3 , -CH 2 CH 2 CH 3 , -CH 2 CH 2 CH 2 CH 3 , -CH(CH 3 ) 2 , -CH 2 CH(CH 3 ) 2 , -CH 2 CH 2 C (CH 3 ) 3 , -CH 2 CH 2 CH(CH 3 )CH 3 , -CH(=CH 2 )CH 3 , -CH 2 CH=CH 2 , -CH 2 -CH=C (CH 3 ) 2 , -CH 2 -C≡CH, -CH 2 -C≡CCH 3 , -CH 2 Ph, -cycPr, -CH 2 cycPr, -CH 2 CH 2 cycPr, -C0 2 CH 3 , -C0 2 CH 2 CH 3 -C0 2 CH 2 CH 2 CH 3 , -CO 2 CH 2 CH 2 CH 2 CH 3 , -C0 2 CH(CH 3 ) 2 , -C0 2 CH 2 CH(CH 3 ) 2 , -C0 2 CH 2 Ph, -C0 2 cycPr, -C0 2 CH 2 cycPr, -C0 2 CH 2 CH=CH 2 , -S0 2 CH 2 CH 3 , -S0 2 CH(CH 3 ) 2 , -COCH 3 , -COCH 2 CH , -COCH 2 CH 2 CH 3 , -COCH(CH 3 ) 2 , and -COCH 2 cycPr; R 2 is selected from: benzyl, phenethyl, -CH 2 CH 2 cycPr, -C≡C-CH 3 , -G≡C-CF 3 , -C≡C-Et, -C≡C-iPr, -C≡C-cycPr, -C≡C-l-(CH 3 )cycPr, -C≡C-CH=CH 2 , -C≡C-C (=CH 2 ) CH 3 , -CH=CH-CH 3 , -CH=CH-CF 3 , -CH=CH-Et, -CH=CH-iPr, -CH=CH-cycPr, -CH=CH-CH=CH 2 , -CH 2 -C≡C-CH 3 , -CH 2 -C≡C-CF 3 , -CH 2 -C≡C-Et, -CH 2 -C≡C-iPr, -CH 2 -C≡C-cycPr, -CH 2 -C≡C-CH=CH 2 , -CH 2 -CH=CH 2 , -CH 2 -CH=CH-CH 3 , -CH 2 -CH=CH-CF 3 , -CH 2 -CH=CH-Et , -CH 2 -CH=CH-iPr, -CH -CH=CH-cycPr , -CH 2 -CH=CH-CH=CH , -CH 2 -CH=C(CH 3 ) 2 , and -CH=CH-CH 2 -cycPr; R 3 is selected from: H, F, Cl, Br, I, -OH, -OCF 3 , -CN, -N0 2 , -C(=0)CH 3 , -C(=0)CF 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -CF 3 , -CH 3 , -CH 2 CH 3 , -OCH3, and -0CH 2 CH 3 , R 4 is selected from: H, F, Cl, Br, I, -OH, OH, -OCF 3 , -CN, -N0 2 , -C(=0)CH 3 , -C(=0)CF 3 , -C(=0)NH 2 , -C(=0)NHCH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHC(=0)OCH 3 , -C(=0)OCH 3 , -CF 3 , -CH3, -CH 2 CH 3 , -OCH3, and -OCH 2 CH 3 ; R 5 is selected from H, F, and Cl; and R 6 is selected from: H, F, Cl -OH, -OCF3, -CF3, -CH3, and -OCH3. In a further preferred embodiment, a compound of the present invention is selected from: 4- (cyclopropylmethyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 4- (methyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4- dihydro-quinoxalin-2 (IH) -one; 3- (n-butyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) - one; 4- (methyl) -3- (n-butyl) -3- (trifluoromethyl) -3, 4-dihydro- quinoxalin-2 (IH) -one; 3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro- quinoxalin-2 (IH) -one; 3- (allyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) - one; 4- (allyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3,4- dihydro-quinoxalin-2 (IH) -one; 4- (benzyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4- dihydro-quinoxalin-2 (IH) -one; 4- (cyclopropylmethyl) -3- (allyl) -3- (trifluoromethyl) -3 , 4- dihydro-quinoxalin-2 (IH) -one; 4- (propargyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) - 3 , 4-dihydro-quinoxalin-2 (IH) -one; 4- (cyclopropylethyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one; 4- (isopropyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) - 3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (fluoro) -4- (allyl) -3- (n-butyl) -3- (trifluoromethyl) -3 , 4- dihydro-quinoxalin-2 (IH) -one; 6- (fluoro) -4- (allyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (fluoro) -4- (cyclopropylmethyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (fluoro) -4- (cyclopropylmethyl) -3- (n-butyl) -3- ( trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (chloro) -4- (cyclopropylmethyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one; 6- (chloro) -4- (isobutyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one; 6- (chloro) -4- (allyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (chloro) -4- (cyclopropylmethyl) -3- (phenethyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (chloro) -4- (allyl) -3- (phenethyl) -3- (trifluoromethyl) -3 , 4- dihydro-quinoxalin-2 (IH) -one; 6- (methoxy) -4- (cyclopropylmethyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (methoxy) -4- (allyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 4- (cyclopropylmethyl) -3- (1-propynyl) -3- (trifluoromethyl) -3 , 4- dihydro-quinoxalin-2 (IH) -one; 4- (allyl) -3- (1-propynyl) -3- (trifluoromethyl) -3 , 4-dihydro- quinoxalin-2 (IH) -one; 4- (ethoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 4- (ethoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one; 4- (isopropoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (propen-2-yl-oxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one; - (isobutoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (n-butoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (allyloxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (benzyloxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (n-propylsulfonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - ( heny1carbony1) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (neopentyl-oxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (2-propynyl-oxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (isopropylcarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (cyclopropylcarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (ethylsulfonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (isopropylsulfonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 4- (methoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (chloro) -4- (ethoxycarbonyl) -3- (2-cyclopropylethynyl) -3- ( trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one; 6- (chloro) -4- (isopropoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (chloro) -4- (propen-2-yl-oxycarbonyl) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro- quinoxalin-2 (IH) -one; 6- (fluoro) -4- (ethoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (fluoro) -4- (isopropoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; and 6- (fluoro) -4- (propen-2-yl-oxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one. In a most preferred embodiment, the present invention provides a novel compound of Formula (I) , Formula (II) or Formula (III) , or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein R 1 , C f , A, W, X, Y, and Z are as defined above; and R 2 is -C≡C-R 8 or - (CHR 7 ) p C≡C-R 8 . In another preferred embodiment, the present invention provides a compound of Formula (lib) : (lib) wherein: A is O or S; W is N or CR 3 ; X is N or CR 4 ; Y is N or CR 5 ; Z is N or CR 6 ; C f is -CF 3 , -CF 2 CF 3 , or -CF 2 CF 2 CF 3 ; provided that one or two of W, X, Y, and Z are N; R 1 is selected from: -C0 2 R 12 , -COR 12 , -S0 2 R 12 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , -C 1 - 5 alkyl substituted with 0-3 R 11 , -(CH 2 ) p phenyl substituted with 0-3 R 10 , and -(CH 2 ) p (C 3 _ 5 cycloalkyl); R 2 is selected from: -CH=CR 7 R 8 , -C≡C-R 8 , -CH=CHCHR 7 R 8 , -(CHR 7 ) p CHR 7 R 8 , - (CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p ϋ≡C-R 8 , -(CH 2 ) p phenyl substituted with 0-3 R 10 , and -(CH 2 ) P (C 3 _ 5 cycloalkyl); R 3 is selected from: H, F, Cl, Br, I, -OH, -OCF 3 , -CN, -N0 2 , -CHO, -C(=0)CH 3 , -C(=0)CF 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -CF 3 , -CH 3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 , R 4 is selected from: H, F, Cl, Br, I, -OH, OH, -OCF 3 , -CN, -N0 2 , -CHO, -C(=0)CH 3 , -C(=0)CF 3 , -C(=0)NH 2 , -C(=0)NHCH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHC(=0)OCH 3 , -C(=0)OCH 3 , -CF 3 , -CH 3 , -CH 2 CH 3 , -OCH 3 , and -0CH 2 CH 3 ; R 5 is selected from H, F, Cl, Br, I, -OH, -CH 3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 ; R 6 is selected from: H, F, Cl, Br, I, -OH, -OCF 3 , -CN, -N0 2 , -CHO, -C(=0)CH 3 , -C(=0)CF 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -CF 3 , -CH 3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 ; R 7 , at each occurrence, is selected from H, methyl, ethyl, propyl, and butyl; R 8 , at each occurrence, is selected from: H, F, Cl, Br, I, CH( -OCH 2 CH 2 0-) , C 1 - 4 haloalkyl, Cι_ 4 alkyl substituted with 0-3 R 11 , C 2 _ 4 alkenyl, C 3 - 6 cycloalkyl substituted with 0-2 R 9 , phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-3 heteroatoms selected from the group consisting of pyridinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, and oxazolidinyl; R 9 , at each occurrence, is selected from D, OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, and F; R 10 , at each occurrence, is selected from OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, F, Cl, Br, I, CN, -NH 2 , -NHCH 3 , -NHCH 2 CH 3 , -N(CH 3 ) 2 , -N(CH 2 CH 3 ) 2 , and C(=0)CH 3 ; R 11 , at each occurrence, is selected from OR 7 , CN, F, Cl, Br, I, N0 2 , -NH 2 , -NHCH 3 , -NHCH 2 CH 3 , -N(CH 3 ) 2 , -N(CH 2 CH 3 ) 2 , CHO, C(=0)CH 3 , C(=0)NH 2 ; R 12 , at each occurrence, is selected from Ci- 6 alkyl, C 2 _ 4 alkenyl, C _ 4 alkynyl, C 3 - 6 cycloalkyl, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-3 heteroatoms selected from the group consisting pyridinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, and oxazolidinyl, -(CH ) p phenyl substituted with 0-2 R 10 , and -(CH 2 ) P (C 3 _ 5 cycloalkyl); and p, at each occurrence, is selected from 0, 1, and 2. In more preferred embodiment, the present invention provides a compound of Formula (Ilia) : (IHb) wherein: R 1 is selected from: -CF 3 , -CF 2 H, -CH 3 , -CH2CH3, -CH 2 CH 2 CH 3 , -CH 2 CH 2 CH 2 CH 3 , -CH(CH 3 ) 2 , -CH 2 CH (CH 3 ) 2 , -CH 2 CH 2 C (CH ) 3 , -CH 2 CH 2 CH(CH 3 )CH 3/ -CH(=CH 2 )CH 3 , -CH 2 CH=CH 2 , -CH 2 -CH=C (CH3 ) 2 , -CH 2 -C≡CH, -CH 2 -C≡CCH 3 , -CH 2 Ph, -cycPr, -CH 2 cycPr, -CH 2 CH 2 cycPr, -C0 2 CH 3 , -C0 2 CH 2 CH 3 , -C0 2 CH 2 CH 2 CH 3 , -C0 2 CH 2 CH 2 CH 2 CH 3 , -C0 2 CH(CH 3 ) 2 , -C0 2 CH 2 CH(CH 3 ) 2 , -C0 2 CH 2 Ph, -C0 2 cycPr, -C0 2 CH 2 cycPr, -C0 2 CH 2 CH=CH 2 , -S0 2 CH2CH 3/ -S0 2 CH (CH 3 ) 2 , -C0CH 3 , -C0CH 2 CH 3 , -C0CH 2 CH 2 CH 3 , -COCH(CH 3 ) 2 , and -COCH 2 cycPr; R 2 is selected from: benzyl, phenethyl, -CH 2 CH 2 cycPr, -C≡C-CH 3 , -C≡C-CF 3 , -C≡C-Et, -C≡C-iPr, -C≡C-cycPr, -C≡C-l-(CH 3 )cycPr, -C≡C-CH=CH 2 , -C≡C-C (=CH 2 ) CH 3 , -CH=CH-CH 3 , -CH=CH-CF 3 , -CH=CH-Et, -CH=CH-iPr, -CH=CH-cycPr, -CH=CH-CH=CH 2 , -CH 2 -C≡C-CH 3 , -CH 2 -C≡C-CF 3 , -CH 2 -C≡C-Et, -CH 2 -C≡C-iPr , -CH 2 -C≡C-cycPr, -CH 2 -C=C-CH=CH 2 , -CH 2 -CH=CH 2 , -CH 2 -CH=CH-CH 3 , -CH 2 -CH=CH-CF 3 , -CH 2 -CH=CH-Et, -CH -CH=CH-iPr, -CH 2 -CH=CH-cycPr , -CH 2 -CH=CH-CH=CH 2 , -CH 2 -CH=C(CH 3 ) 2 , and -CH=CH-CH 2 -cycPr; R 3 is selected from: H, F, Cl, Br, I, -OH, -OCF 3 , -CN, -N0 2 , -C(=0)CH 3 , -C(=0)CF 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -CF3, -CH 3 , -CH2CH 3 , -OCH 3 , and -OCH2CH3, R 4 is selected from: H, F, Cl, Br, I, -OH, OH, -OCF 3 , -CN, -N0 2 , -C(=0)CH 3 , -C(=0)CF 3 , -C(=0)NH 2 , -C(=0)NHCH 3 , -NH 2 , -NHCH3 , -N(CH 3 ) 2 , -NHC(=0)OCH 3 , -C(=0)OCH 3 , -CF3, -CH3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 ; R 5 is selected from H, F, and Cl; and R 6 is selected from: H, F, Cl -OH, -OCF3, -CF 3 , -CH 3 , and -OCH3. In another preferred embodiment, the present invention provides a compound of Formula (la) or (lb) : la lb or a stereoisomer or pharmaceutically acceptable salt form thereof . In a second embodiment, the present invention provides a novel pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of formula (I) or pharmaceutically acceptable salt form thereof. In a third embodiment, the present invention provides a novel method for treating HIV infection which comprises administering to a host in need of such treatment a therapeutically effective amount of a compound of formula (I) or pharmaceutically acceptable salt form thereof. In a fourth embodiment, the present invention provides a novel method of treating HIV infection which comprises administering, in combination, to a host in need thereof a therapeutically effective amount of : (a) a compound of Formula (I) ; and, (b) at least one compound selected from the group consisting of HIV reverse transcriptase inhibitors and HIV protease inhibitors . In another preferred embodiment, the reverse transcriptase inhibitor is a nucleoside reverse transcriptase inhibitor . In another more preferred embodiment, the HIV reverse transcriptase inhibitor is selected from AZT, 3TC, rescriptor, ddl, ddC, efavirenz, and d4T and the protease inhibitor is selected from saquinavir, ritonavir, indinavir, VX-478, nelfinavir, KNI-272, CGP-61755, and U-103017. In an even more preferred embodiment, the HIV reverse transcriptase inhibitor is selected from AZT, rescriptor, efavirenz, and 3TC and the protease inhibitor is selected from saquinavir, ritonavir, indinavir, and nelfinavir. In a still further preferred embodiment, the nucleoside reverse transcriptase inhibitor is AZT. In another still further preferred embodiment, the HIV reverse transcriptase inhibitor is efavirenz . In another still further preferred embodiment, the protease inhibitor is indinavir. In a fifth embodiment, the present invention provides a pharmaceutical kit useful for the treatment of HIV infection, which comprises a therapeutically effective amount of: (a) a compound of Formula (I) ; and, (b) at least one compound selected from the group consisting of HIV reverse transcriptase inhibitors and HIV protease inhibitors, in one or more sterile containers. In a sixth embodiment, the present invention provides a novel method of inhibiting HIV present in a body fluid sample which comprises treating the body fluid sample with an effective amount of a compound of Formula (I) . In a seventh embodiment, the present invention to provides a novel a kit or container comprising a compound of formula (I) in an amount effective for use as a standard or reagent in a test or assay for determining the ability of a potential pharmaceutical to inhibit HIV reverse transcriptase, HIV growth, or both. DEFINITIONS As used herein, the following terms and expressions have the indicated meanings . It will be appreciated that the compounds of the present invention contain an asymmetrically substituted carbon atom, and may be isolated in optically active or racemic forms. It is well known in the art how to prepare optically active forms, such as by resolution of racemic forms or by synthesis, from optically active starting materials. All chiral, diastereomeric, racemic forms and all geometric isomeric forms of a structure are intended, unless the specific stereochemistry or isomer form is specifically indicated. The processes of the present invention are contemplated to be practiced on at least a multigram scale, kilogram scale, multikilogram scale, or industrial scale. Multigram scale, as used herein, is preferably the scale wherein at least one starting material is present in 10 grams or more, more preferably at least 50 grams or more, even more preferably at least 100 grams or more. Multikilogram scale, as used herein, is intended to mean the scale wherein more than one kilogram of at least one starting material is used. Industrial scale as used herein is intended to mean a scale which is other than a laboratory scale and which is sufficient to supply product sufficient for either clinical tests or distribution to consumers. The reactions of the synthetic methods claimed herein may be, as noted herein, carried out in the presence of a suitable base, said suitable base being any of a variety of bases, the presence of which in the reaction facilitates the synthesis of the desired product. Suitable bases may be selected by one of skill in the art of organic synthesis. Suitable bases include, but are not intended to be limited to, inorganic bases such as alkali metal, alkali earth metal, thallium, and ammonium hydroxides, alkoxides, phosphates, and carbonates, such as sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, cesium carbonate, thallium hydroxide, thallium carbonate, tetra-n-butylammonium carbonate, and ammonium hydroxide. Suitable bases also include organic bases, including but not limited to aromatic and aliphatic amines, such as pyridine; trialkyl amines such as triethylamine, N,N-diisopropylethylamine, N,N-diethylcyclohexylamine, N,N-dimethylcyclohexylamine, N,N,N' -triethylenediamine, N,N-dimethyloctylamine; 1, 5-diazabicyclo[4.3.0]non-5-ene (DBN) ; l,4-diazabicyclo[2.2.2]octane (DABCO) ; 1, 8-diazabicyclo[5.4.0]undec-7-ene (DBU) ; tetramethylethylenediamine (TMEDA) ; and substituted pyridines such as N,N-dimethylaminopyridine (DMAP) , 4-pyrrolidinopyridine, 4-piperidinopyridine . Suitable halogenated solvents include: carbon tetrachloride, bromodichloromethane, dibromochloromethane, bromoform, chloroform, bromochloromethane, dibromomethane, butyl chloride, dichloromethane, tetrachloroethylene, trichloroethylene, 1, 1, 1-trichloroethane, 1,1,2- trichloroethane, 1, 1-dichloroethane, 2-chloropropane, hexafluorobenzene, 1, 2, 4-trichlorobenzene, o-dichlorobenzene, chlorobenzene, or fluorobenzene. Suitable ether solvents include, but are not intended to be limited to, dimethoxymethane, tetrahydrofuran, 1,3- dioxane, 1,4-dioxane, furan, diethyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, triethylene glycol dimethyl ether, or t-butyl methyl ether. Suitable protic solvents may include, by way of example and without limitation, water, methanol, ethanol, 2- nitroethanol, 2-fluoroethanol, 2, 2, 2-trifluoroethanol, ethylene glycol, 1-propanol, 2-propanol, 2-methoxyethanol, 1- butanol, 2-butanol, i-butyl alcohol, t-butyl alcohol, 2- ethoxyethanol , diethylene glycol, 1-, 2-, or 3- pentanol, neo-pentyl alcohol, t-pentyl alcohol, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, cyclohexanol, anisole, benzyl alcohol, phenol, or glycerol. Suitable aprotic solvents may include, by way of example and without limitation, tetrahydrofuran (THF) , dimethylformamide (DMF), dimethylacetamide (DMAC) , 1,3- dimethyl-3,4,5, 6-tetrahydro-2 (IH) -pyrimidinone (DMPU) , 1,3- dimethyl-2-imidazolidinone (DMI) , N-methylpyrrolidinone (NMP) , formamide, N-methylacetamide, N-methylformamide, acetonitrile, dimethyl sulfoxide, propionitrile, ethyl formate, methyl acetate, hexachloroacetone, acetone, ethyl methyl ketone, ethyl acetate, sulfolane, N,N- dimethylpropionamide, tetramethylurea, nitromethane, nitrobenzene, or hexamethylphosphoramide . Suitable hydrocarbon solvents include, but are not intended to be limited to, benzene, cyclohexane, pentane, hexane, toluene, cycloheptane, methylcyclohexane, heptane, ethylbenzene, m-, o-, or p-xylene, octane, indane, nonane, or naphthalene . As used herein, the term "amine protecting group" (or "N-protected" ) refers to any group known in the art of organic synthesis for the protection of amine groups. As used herein, the term "amine protecting group reagent" refers to any reagent known in the art of organic synthesis for the protection of amine groups which may be reacted with an amine to provide an amine protected with an amine protecting group. Such amine protecting groups include those listed in Greene and Wuts, "Protective Groups in Organic Synthesis" John Wiley & Sons, New York (1991) and "The Peptides: Analysis, Synthesis, Biology, Vol. 3, Academic Press, New York (1981), the disclosure of which is hereby incorporated by reference. Examples of amine protecting groups include, but are not limited to, the following: 1) acyl types such as formyl, trifluoroacetyl, phthalyl, and p-toluenesulfonyl; 2) aromatic carbamate types such as benzyloxycarbonyl (Cbz) and substituted benzyloxycarbonyls, 1- (p-biphenyl) -1- methylethoxycarbonyl, and 9-fluorenylmethyloxycarbonyl (Fmoc) ; 3) aliphatic carbamate types such as tert- butyloxycarbonyl (Boc) , ethoxycarbonyl, diisopropylmethoxycarbonyl, and allyloxycarbonyl; 4) cyclic alkyl carbamate types such as cyclopentyloxycarbonyl and adamantyloxycarbonyl; 5) alkyl types such as triphenylmethyl (trityl) and benzyl; 6) trialkylsilane such as trimethylsilane; and 7) thiol containing types such as phenylthiocarbonyl and dithiasuccinoyl . Amine protecting groups may include, but are not limited to the following: 2, 7-di-t-butyl- [9- (10, 10-dioxo-lO, 10, 10, 10- tetrahydrothio-xanthyl) ]methyloxycarbonyl; 2-trimethylsilyl- ethyloxycarbonyl; 2-phenylethyloxycarbonyl; 1, l-dimethyl-2 , 2- dibromoethyloxycarbonyl ; 1-methyl-l- (4-biphenylyl) - ethyloxycarbonyl; benzyloxycarbonyl ; p-nitrobenzyl- oxycarbonyl ; 2- (p-toluenesulfonyl ) ethyloxy-carbony1 ; m-chloro-p-acyloxybenzyloxycarbonyl; 5-benzyisoxazolyl- methyloxycarbonyl ; p- (dihydroxyboryl)benzyloxycarbonyl ; m-nitrophenyloxycarbonyl; o-nitrobenzyloxycarbonyl; 3 , 5-dimethoxybenzyloxycarbonyl ; 3 , 4-dimethoxy-6-nitrobenzyl- oxycarbonyl; N' -p-toluenesulfonylaminocarbonyl ,- t-amyloxy- carbonyl; p-decyloxybenzyloxycarbonyl ; diisopropylmethyloxy- carbonyl ; 2,2-dimethoxycarbonylvinyloxycarbonyl ; di (2- pyridyl)methyloxycarbonyl ; 2-furanylmethyloxycarbonyl ; phthalimide; dithiasuccinimide; 2 , 5-dimethylpyrrole; benzyl; 5-dibenzylsuberyl ; triphenylmethyl ; benzylidene; diphenylmethylene; or methanesulfonamide. As used herein, "alkyl" is intended to include both branched and straight-chain saturated aliphatic hydrocarbon groups having the specified number of carbon atoms; for example, "Cι~ 6 alkyl" denotes alkyl having 1 to 6 carbon atoms, ie. methyl, ethyl, propyl, butyl, pentyl, hexyl, and branched isomers therin.. Examples of alkyls include, but are not limited to, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl, t-butyl, i-pentyl, n-pentyl, and s-pentyl. "Haloalkyl" is intended to include both branched and straight-chain saturated aliphatic hydrocarbon groups having the specified number of carbon atoms, substituted with 1 or more halogen (for example -C V F W where v = 1 to 3 and w = 1 to (2v+l) ) . Examples of haloalkyl include, but are not limited to, trifluoromethyl, trichloromethyl , pentafluoroethyl, pentachloroethyl , 2, 2, 2-trifluoroethyl, heptafluoropropyl, and heptachloropropyl . "Alkoxy" represents an alkyl group as defined above with the indicated number of carbon atoms attached through an oxygen bridge. Examples of alkoxy include, but are not limited to, methoxy, ethoxy, n-propoxy, i-propoxy, n-butoxy, s-butoxy, t-butoxy, n-pentoxy, and s-pentoxy. "Cycloalkyl" is intended to include saturated ring groups, such as cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl . "Alkenyl" is intended to include hydrocarbon chains of either a straight or branched configuration and one or more unsaturated carbon-carbon bonds which may occur in any stable point along the chain, such as ethenyl, propenyl, butenyl and the like. "Alkynyl" is intended to include hydrocarbon chains of either a straight or branched configuration and one or more triple carbon-carbon bonds which may occur in any stable point along the chain, such as ethynyl, propynyl, butynyl and the like. "Halo" or "halogen" as used herein refers to fluoro, chloro, bromo and iodo. "Counterion" is used to represent a small, negatively charged species such as chloride, bromide, hydroxide, acetate, sulfate and the like. As used herein, "aryl" or "aromatic residue" is intended to mean an aromatic moiety containing the specified number of carbon atoms, such as phenyl or naphthyl. As used herein, "carbocycle" or "carbocyclic residue" is intended to mean any stable 3- to 7- membered monocyclic or bicyclic or 7- to 14- membered bicyclic or tricyclic carbon ring, which may be saturated or partially unsaturated. Examples of such carbocyles include, but are not limited to, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, biphenyl, naphthyl, indanyl, adamantyl, or tetrahydronaphthyl (tetralin) . As used herein, the term "heterocycle" or "heterocyclic system" is intended to mean a stable 5- to 6- membered monocyclic heterocyclic ring which is saturated partially unsaturated or unsaturated (aromatic) , and which consists of carbon atoms and from 1 to 3 heteroatoms independently selected from the group consisting of N, O and S. The nitrogen and sulfur heteroatoms may optionally be oxidized. The heterocyclic ring may be attached to its pendant group at any heteroatom or carbon atom which results in a stable structure. The heterocyclic rings described herein may be substituted on carbon or on a nitrogen atom if the resulting compound is stable. If specifically noted, a nitrogen in the heterocycle may optionally be quaternized. It is preferred that when the total number of S and O atoms in the heterocycle exceeds one, then these heteroatoms are not adjacent to one another. It is preferred that the total number of S and 0 atoms in the heterocycle is not more than one. As used herein, the term "aromatic heterocyclic system" is intended to mean a stable 5- to 6- membered monocyclic heterocyclic aromatic ring which consists of carbon atoms and from 1 to 3 heterotams independently selected from the group consisting of N, 0 and S. It is preferred that the total number of S and 0 atoms in the aromatic heterocycle is not more than one. Examples of heterocycles include, but are not limited to, 2-pyrrolidonyl, 2H-pyrrolyl, 4-piperidonyl, 6H-1,2,5- thiadiazinyl, 2 H, 6H-1 , 5, 2-dithiazinyl, furanyl, furazanyl, imidazolidinyl, imidazolinyl, imidazolyl, isoxazolyl, morpholinyl, oxadiazolyl, 1, 2, 3-oxadiazolyl, 1,2,4- oxadiazolyl, 1, 2, 5-oxadiazolyl, 1, 3 , 4-oxadiazolyl, oxazolidinyl . , oxazolyl, piperazinyl, piperidinyl, pteridinyl, piperidonyl, 4-piperidonyl, piperonyl, pteridinyl, purinyl, pyranyl, pyrazinyl, pyrazolidinyl, pyrazolinyl, pyrazolyl, pyridazinyl, pyridinyl, pyridyl, pyrimidinyl, pyrrolidinyl, pyrrolinyl, pyrrolyl, tetrahydrofuranyl, 6H-1, 2 , 5-thiadiazinyl, 1, 2, 3-thiadiazolyl, 1,2,4-thiadiazolyl, 1, 2 , 5-thiadiazolyl, 1, 3 , 4-thiadiazolyl, thiazolyl, thienyl, thienothiazolyl, thienooxazolyl , thienoimidazolyl, thiophenyl, triazinyl, 1, 2, 3-triazolyl, 1, 2,4-triazolyl, 1, 2, 5-triazolyl, and 1, 3 , 4-triazolyl . Preferred heterocycles include, but are not limited to, pyridinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, and oxazolidinyl . Also included are fused ring and spiro compounds containing, for example, the above heterocycles. As used herein, "HIV reverse transcriptase inhibitor" is intended to refer to both nucleoside and non- nucleoside inhibitors of HIV reverse transcriptase (RT) . Examples of nucleoside RT inhibitors include, but are not limited to, AZT, ddC, ddl, d4T, and 3TC. Examples of non- nucleoside RT inhibitors include, but are not limited to, efavirenz (DuPont Merck) , rescriptor (delavirdine, Pharmacia and Upjohn) , viviradine (Pharmacia and Upjohn U90152S) , PNU142721 (Pharmacia and Upjohn), TIBO derivatives, BI-RG- 587, nevirapine, L-697,661, LY 73497, and Ro 18,893 (Roche). As used herein, "HIV protease inhibitor" is intended to refer to compounds which inhibit HIV protease. Examples include, but are not limited, saquinavir (Roche, Ro31-8959), ritonavir (Abbott, ABT-538) , indinavir (Merck, MK-639) , VX- 478 (Vertex/Glaxo Wellcome), nelfinavir (Agouron, AG-1343), KNI-272 (Japan Energy) , CGP-61755 (Ciba-Geigy) , DMP450 (DuPont Merck), and U-103017 (Pharmacia and Up ohn). Additional examples include the cyclic protease inhibitors disclosed in WO93/07128, W094/19329, WO94/22840, and PCT Application Number US96/03426 and the protease inhibitors disclosed in WO94/04993, W095/33464, W096/28,418, and W096/28,464. As used herein, "pharmaceutically acceptable salts" refer to derivatives of the disclosed compounds wherein the parent compound is modified by making acid or base salts thereof. Examples of pharmaceutically acceptable salts include, but are not limited to, mineral or organic acid salts of basic residues such as amines; alkali or organic salts of acidic residues such as carboxylic acids; and the like. The pharmaceutically acceptable salts include the conventional non-toxic salts or the quaternary ammonium salts of the parent compound formed, for example, from non-toxic inorganic or organic acids. For example, such conventional non-toxic salts include those derived from inorganic acids such as hydrochloric, hydrobromic, sulfuric, sulfamic, phosphoric, nitric and the like; and the salts prepared from organic acids such as acetic, propionic, succinic, glycolic, stearic, lactic, malic, tartaric, citric, ascorbic, pamoic, maleic, hydroxymaleic , phenylacetic, glutamic, benzoic, salicylic, sulfanilic, 2-acetoxybenzoic, fumaric, toluenesulfonic, methanesulfonic, ethane disulfonic, oxalic, isethionic, and the like. The pharmaceutically acceptable salts of the present invention can be synthesized from the parent compound which contains a basic or acidic moiety by conventional chemical methods. Generally, such salts can be prepared by reacting the free acid or base forms of these compounds with a stoichiometric amount of the appropriate base or acid in water or in an organic solvent, or in a mixture of the two; generally, nonaqueous media like ether, ethyl acetate, ethanol, isopropanol, or acetonitrile are preferred. Lists of suitable salts are found in Remington 's Pharmaceutical Sciences, 17th ed. , Mack Publishing Company, Easton, PA, 1985, p. 1418, the disclosure of which is hereby incorporated by reference. The phrase "pharmaceutically acceptable" is employed herein to refer to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication commensurate with a reasonable benefit/risk ratio. "Prodrugs" are intended to include any covalently bonded carriers which release the active parent drug according to formula (I) or other formulas or compounds of the present invention in vivo when such prodrug is administered to a mammalian subject. Prodrugs of a compound of the present invention, for example formula (I) , are prepared by modifying functional groups present in the compound in such a way that the modifications are cleaved, either in routine manipulation or in vivo, to the parent compound. Prodrugs include compounds of the present invention wherein the hydroxy or amino group is bonded to any group that, when the prodrug is administered to a mammalian subject, cleaves to form a free hydroxyl or free amino, respectively. Examples of prodrugs include, but are not limited to, acetate, formate and benzoate derivatives of alcohol and amine functional groups in the compounds of the present invention, and the like. "Stable compound" and "stable structure" are meant to indicate a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into an efficacious therapeutic agent . Only stable compounds are contempleted by the present inventio . "Substituted" is intended to indicate that one or more hydrogens on the atom indicated in the expression using "substituted" is replaced with a selection from the indicated group (s), provided that the indicated atom's normal valency is not exceeded, and that the substitution results in a stable compound. When a substituent is keto (i.e., =0) group, then 2 hydrogens on the atom are replaced. "Therapeutically effective amount" is intended to include an amount of a compound of the present invention or an amount of the combination of compounds claimed effective to inhibit HIV infection or treat the symptoms of HIV infection in a host. The combination of compounds is preferably a synergistic combination. Synergy, as described for example by Chou and Talalay, Adv. Enzyme Regul. 22:27-55 (1984) , occurs when the effect (in this case, inhibition of HIV replication) of the compounds when administered in combination is greater than the additive effect of the compounds when administered alone as a single agent. In general, a synergistic effect is most clearly demonstrated at suboptimal concentrations of the compounds . Synergy can be in terms of lower cytotoxicity, increased antiviral effect, or some other beneficial effect of the combination compared with the individual components . SYNTHESIS The compounds of the present invention can be prepared in a number of ways well known to one skilled in the art of organic synthesis. The compounds of the present invention can be synthesized using the methods described below, together with synthetic methods known in the art of synthetic organic chemistry, or variations thereon as appreciated by those skilled in the art. Preferred methods include but are not limited to those methods described below. Each of the references cited below are hereby incorporated herein by reference. The following abbreviations are used herein: cycPr cyclopropyl ACN acetonitrile AcOH acetic acid CAN eerie ammonium nitrate DCE dichloroethane DIBAL-H diisobutylaluminum hydride DIPEA diisopropylethylamine DMAP 4-dimethylaminopyridine DMF N,iV-dimethylformamide EtOAc ethyl acetate EtOH ethyl alcohol MCPBA m-chloroperoxybenzoic acid PMBC1 p-methoxybenzyl chloride pyr pyridine SEMC1 2 , - (trimethylsilyl) ethoxymethyl chloride TEA triethyl amine TFA trifluoroacetic acid THF tetrahydrofuran In the Schemes which follow: C f is shown as a CF3 group, but could be any one of the presently described R 1 groups; G represents R 3 , R 3a , R 3b , or R 3c or any combination of these groups . Scheme 1 illustrates a method for making 3,3- disubstituted-3 , 4-dihydroquinoxalin-2-ones starting from an appropriately substituted ort o-phenylenediamine . The phenylenediamine is stirred with condensed hexafluoro- propylene oxide to form compounds of formula !_,_ after which the cyclic amide moiety of 1 is protected, for example with SEM, to form compounds of formula 2. Addition of appropriately substituted organometallics, R 2 M, provide the 3 , 3-disubstituted compounds 3. Treatment with base is followed by the addition of an appropriately substituted alkyl halide, R 1 Br, to form compounds of formula 4. The product 4 are deprotected to give compounds of the present invention . SCHEME 1 Hexaf luoropropylene oxide NaHC0 3 , ether SEMC1, DIPEA, DMF R M, THF 3 4 S 1 R 2 BF 3 .Et 2 0, CH 2 C1 2 ' "^ " ^ W H c?' 5 SCHEME la CF 3 In Scheme la illustrates a method, analogous to Scheme 1, of making derivatives to tetrahydroquinoxalinone compounds of formula 5 wherein W, X, Y, and/or Z are nitrogen. SCHEME 2 Scheme 2 illustrates the acylation of 3,4-dihydro- quinoxalin-2-ones . Treatment of compounds of formula 3, as can be prepared by Scheme 1, with base is followed by the addition of an appropriately substituted chloroformate, R 12 C0 2 C1 to form compounds of formula 6. The product 6 is deprotected to give compounds of formula 7. SCHEME 3 In analogous fashion to Scheme 2 , treatment of a compound of formula 3 with base followed by an appropriately substituted sulfonyl chloride, R 12 S0 2 C1, provide protected compounds 8 , as shown in Scheme 3. The product is deprotected to give compounds of formula 9. Analogous to Schemes 2 and 3 , Scheme 4 describes the preparation of amides, 10, from acid chlorides R 12 COCl . In an alternative route to the synthesis of 3,4- dihydroquinoxalin-2-ones, as shown in Scheme 5, a substituted quinoxalin-2-one, 1, can be O-protected to form a compound of formula 12. The addition of an organometallic reagent R 2 M followed by the quenching of the resulting anion with a chloroformate can produce compounds of formula 13. The deprotection of a compound 13 will result in compounds of formula 7. SCHEME 4 R 12 C0C1, nBuLi, THF > 3 10 11 SCHEME 5 12 (1) nBuLi, THF, RM (2) Nal, EtCOOCl, THF 13 Scheme 6 illustrates yet another route for the preparation of compounds of the present invention. N-oxide compound 15 can provide a substrate for the addition of organometallic species R 2 M, followed by the reductive cleavage of the resulting N-hydroxy compound to form compounds of formula 17. Subsequent substitution at the 4-position by R 1 radicals is performed as previously described. Compounds the present invention that are thioamides can be prepared as illustrated in Sce e 7 by treating the corresponding amides with either Lawesson's reagent [2,4- bis (4-methoxyphenyl) -1, 3-dithia-2, 4-diphosphetane-2, 4- disulfide] or phosphorous pentasulfide. SCHEME 6 14 mCPBA, CH 2 C1 2 15 16 17 R x Br , fc BuOK , THF SCHEME 7 One isomer of a compound of Formula (I) may display superior activity compared with the other. Thus, both of the following stereochemistries, (la) and (lb), are considered to be a part of the present invention. ( la) ( lb) When required, separation of the racemic material can be achieved by HPLC using a chiral column or by a resolution using a resolving agent such as camphonic chloride as in Steven D. Young, et al, Antimicrobial Agents and Chemotheraphy, 1995, 2602-2605. A chiral compound of Formula (I) may also be directly synthesized using a chiral catalyst or a chiral ligand, e.g. Andrew S. Thompson, et al, Tet . lett . 1995, 36, 8937-8940. In addition, separation may be achieved by selective cystallization, optionally in the presence of a chiral acid or base thereby forming a chiral salt. Other features of the invention will become apparent in the course of the following descriptions of exemplary embodiments which are given for illustration of the invention and are not intended to be limiting thereof. Examples Abbreviations used in the Examples are defined as follows: anal, for combustion analysis, "g" for gram or grams, HRMS for high resolution mass spectrometry, "mg" for milligram or milligrams, "mL" for milliliter or milliliters, "mmol" for millimole or millimoles, "h" for hour or hours, "HPLC" for high performance liquid chromatography, "M" for molar, "min" for minute or minutes, "MHz" for megahertz, "MS" for mass spectroscopy, "TLC" for thin layer chromatography. For further clarification of the stereochemistry, in compounds with stereochemistry designated as "rel- (3S, 5S) " the 3-substituent is cis to the 5-trifluoromethyl group while in compounds with stereochemistry designated as "rel- (3R, 5S) " the 3-substituent is trans to the 5-trifluoromethyl group. EXAMPLE 1 Preparation of 4- (cyclopropylmethyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-ςpιinoxalin-2(lH) -one. Step A: Preparation of compound of formula 1 wherein G = H To a slurry of 1, 2-phenylenediamine (10.8 g, 100 mmol) in ether (200 mL) at room temperature was added sodium bicarbonate (25.4 g, 300 mmol) followed by the condensation of hexafluoropropylene oxide (21 g, 120 mmol) and the resulting reaction mixture was allowed to stir at room temperature for 3 hours . The reaction mixture is diluted with water (500 mL) and extracted with EtOAc (3x200 mL) . The combined EtOAc extracts were dried over anhydrous Na Sθ 4 and concentrated in vacuo to provide 19.3 g of compound of formula 1 (21.4 g theoretical, 90%). 3-H NMR (300 MHz, CD 3 COCD 3 ) δ 11.67 (br s, IH) , 7.93 (m, IH) , 7.75(m, IH) , 7.46 (m, 2H) . 19 F NMR (282 MHz, CD 3 COCD 3 ) δ -70.93 (s, 3F) . High resolution mass spec : calculated for CgH 6 NOF 3 (M+H) + : 215.0423; found: 215.0432. Step B: Preparation of compound of formula 2 wherein G = H To a solution of quinoxalin-2-one of formula 1 (5.64 g, 26.3 mmol) in DMF (120 mL) at room temperature was added diisopropylethylamine (18.32 mL, 105.2 mmol) followed by SEMCl (9.28 mL, 52.6 mmol) and the resulting reaction mixture was allowed to stir at room temperature for 14 hours. The reaction mixture is poured onto IN HCl and extracted with ether (3x100 mL) . The combined ether extracts were dried over anhydrous Na 2 Sθ 4 and concentrated in vacuo. Chromatography (Si0 2 , 10% EtOAc-hexanes eluant) provided 8.15 g of compound of formula 2 (9.05 g theoretical, 90%) . ^H NMR (300 MHz, CDC1 3 ) δ 8.02 (m, IH) , 7.74(m, 2H) , 7.48(m, IH) , 5.77(s, 2H) , 3.74(t, J = 8Hz, 2H) , 0.98(t, J = 8Hz, 2H) , O.OKs, 9H) . 19 F NMR (282 MHz, CDCI 3 ) δ -61.53 s, 3F) . Mass spec. (NH 3 -CI) : 345(M+H) + (54.6%), 317 (100%). Step C : Preparation of compound of formula 3 wherein G = H, R2 - cyclopropylacetylene To a solution of cyclopropylacetylene (23.4 mL, 106.2 mmol) in THF (150 mL) at 0°C was added nBuLi (59 mL, 94.4 mmol) and the resulting reaction mixture was allowed to stir at 0°C for 30 minutes. Thereafter the reaction mixture was cannulated to stirred solution of quinoxalinone of formula 2 (8.15 g, 23.6 mmol) in THF (300 mL) at -78°C. The dry ice bath is removed and the reaction mixture is stirred for an additional 20 minutes. The reaction mixture is poured onto saturated NH 4 CI and extracted with ether (3x100 mL) and the combined ether extracts were dried over anhydrous Na 2 Sθ 4 and concentrated in vacuo. Chromatography (Si0 2 , 10% EtOAc- hexanes eluant) provided 8.95 g of compound of formula 3, (9.68 g theoretical, 92%). 3-H NMR (300 MHz, CDCI 3 ) δ 7.36m, IH) , 7.26(m, IH) , 7.08(m, 2H) , 6.91(m, IH) , 5.52(d, J = 11Hz, IH) , 5.30(d, J " = 11Hz, IH) , 3.61(t, J = 8Hz, 2H) , 1.38(m, IH) , 0.93 (t, J = 8Hz, 2H) , 0.85(m, 2H) , 0.54(m, 2H) . 19 F NMR (282 MHz, CDCI 3 ) δ -75.22(s, 3F) . Mass spec. (NH 3 -CI) : 411(M+H) + , 5.2%, 383 (100%). Step D: Preparation of compound of formula 4 wherein G = H, R^ - cyclopropylacetylene and R^ = cyclopropylmethyl To a solution of protected quinoxalinone of formula 3 (123 mg, 0.3 mmol) in DMF (4 mL) at room temperature was added tβuOK in THF (1.5 mL, 1.5 mmol) was added cyclopropylmethyl bromide (290 μl, 3.0 mmol) and the resulting reaction mixture was allowed to stir at 80°C for 14 hours. The reaction mixture is poured onto water and extracted with ether (3x50 mL) and the combined ether extracts were dried over anhydrous Na S04 and concentrated in vacuo. Chromatography (Si0 2 , 10% EtOAc-hexanes eluant) provided 69 mg of compound of formula 4, (139 mg theoretical, 50%). NMR (300 MHz, CDC1 3 ) δ 7.42 (m, IH) , 7.12 (m, IH) , 7.02 (m, IH) , 6.94(m, IH) , 5.94(d, J = 11Hz, IH) , 5.05(d, J = 11Hz, IH) , 3.9(m, IH) , 3.68(t, J = 8Hz, 2H) , 3.45(m, IH) , 1.42(m, IH) , 1.2 (m, IH) , 0.9(m, 6H) , 0.6(m, IH) , 0.45 (m, IH) , 0.35(m, 2H) , 0.01(s, 9H) . Mass spec. (NH3-CI) : 465(M+H) + , 50%, 437 (90%), 335 (M-SEM+H + , 100%) . Step E: To a solution of the alkylated quinoxalinone of formula 4 (69 mg, 0.15 mmol) in CH 2 C1 2 (1 L) at room temperature was added BF3.Et 2 0 (95 μL, 0.75 mmol) and the resulting reaction mixture was allowed to stir at room temperature for 20 minutes. The reaction mixture was poured onto saturated NaHCθ3 and extracted with CH C1 (3x25 mL) and the combined CH 2 C1 2 extracts were dried over anhydrous Na Sθ4 and concentrated in vacuo. The residue was taken up in MeOH (1 mL) and 15% NaOH (lmL) was added to the reaction and the resulting reaction mixture was allowed to stir at room temperature for 10 minutes . The reaction mixture was poured onto water and extracted with CH C1 2 (3x25 mL) and the combined CHC1 extracts were dried over anhydrous Na 2 S04 and concentrated in vacuo. Chromatography (Si0 2 , 10% EtOAc-hexanes eluant) provided 41 mg of the title compound, (50 mg theoretical, 82%). X H NMR (300 MHz, CDCI3) δ 9.46(br s, IH) , 7.1(m, IH) , 6.95(m, IH) , 6.85(m, 2H) , 3.87(dd, J = 4, 15Hz, IH) , 3.35(dd, J = 8, 15Hz), 1.4(m, IH) , 1.2 (m, IH) , 0.9(m, 4H) , 0.6(m, IH) , 0.4(m, 3H) . 19 F NMR (282 MHz, CDCI3) δ -73.38(s, 3F) . High resolution mass spec: calculated for Ci8HιgN 2 OF3 (M+H) + : 335.1371; found: 335.1371. EXAMPLE 2 Preparation of 4- (methyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step D methyl iodide was used instead of cyclopropylmethyl bromide: ^H NMR (300 MHz, CDC1 3 ) δ 8.75(br s, IH) , 7.1(m, IH) , 6.85(m, 3H) , 3.25(s, 3H) , 1.4 (m, IH) , 0.85 (m, 4H) . High resolution mass spec: calculated for Cι 5 Hi 4 N 2 OF 3 (M+H) + : 295.1058; found: 295.1073. EXAMPLE 3 Preparation of 3- (n-butyl) -3- (trifluoromethyl) -3, 4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step C n-butyl magnesium chloride was used instead of lithium cyclopropyl acetylide: 3-H NMR (300 MHz, CDCI 3 ) δ 8.8 (br s, IH) , 6.9 ( , IH) , 6.75 (m, 3H) , 4.05(s, IH) , 2.2 (m, IH) , 1.85(m, 2H) , 1.35 (m, 2H) , 0.9 (m, 3H) . High resolution mass spec: calculated for Cι 3 Hi 6 N 2 0F 3 (M+H) + : 273.1214; found: 273.1210. EXAMPLE 4 Preparation of 4- (methyl) -3- (n-butyl) -3- (trifluoromethyl) - 3,4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step C n-butyl magnesium chloride was used instead of lithium cyclopropyl acetylide and in Step D methyl iodide was used instead of cyclopropylmethyl bromide: !H NMR (300 MHz, CDCI 3 ) δ 8.85 (br s, IH) , 7.05(m, IH) , 6.8 (m, 3H) , 2.95(s, 3H) , 2.65(m, 2H) , 2. l(m, IH) , 1.4 (m, 4H) , 0.95(m, 3H) . High resolution mass spec: calculated for Ci 4 Hι 8 N 2 OF 5 (M+H) + : 287.1371; found: 287.1362. EXAMPLE 5 Preparation of 3- (2-cyclopropylethynyl) -3- (trifluoromethyl) - 3, 4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, Step C: 3-H NMR (300 MHz, CDCI 3 ) δ 9.0(br s, IH) , 7.0 (m, IH) , 6.85 (m, 2H) , 6.8 (m, IH) , 4.45 (br s, IH) , 1.4(m, IH) , 0.8-0.6 (m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -77.13 (s, 3F) . High resolution mass spec: calculated for Ci 4 HnN 2 OF 5 (M) + : 280.0823; found: 280.0828. EXAMPLE 6 Preparation of 3- (allyl) -3- (trifluoromethyl) -3,4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step C allyl magnesium bromide was used instead of lithium cyclopropyl acetylide: ^ NMR (300 MHz, CDCI 3 ) δ 8.25(br s, IH) , 6.95(m, IH) , 6.75(m, 3H) , 5.85(m, IH) , 5.25(m, 2H) , 4.2(br s, IH) , 3. l(m, IH) , 2.65(m, IH) . 19 F NMR (282 MHz, CDC1 3 ) δ -71.16(s, 3F) . High resolution mass spec: calculated for Cι 2 Hι 2 N 2 OF3 (M+H) + : 257.0901; found: 257.0898. EXAMPLE 7 Preparation of 4- (allyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step D allyl iodide was used instead of cyclopropylmethyl bromide: ^H NMR (300 MHz, CDCI3) δ 9.4(br s, IH) , 7.0 (m, IH) , 6.8(m, 3H) , 5.8(m, IH) , 5.2 ( , 2H) , 4.6(m, IH) , 4.2 ( , IH) , 1.4 (m, IH) , 0.9 (m, 4H) . 19 F NMR (282 MHz, CDCI3) δ -74.49(s, 3F) . High resolution mass spec: calculated for Ci7Hi6N 2 OF3 (M+H) + : 321.1214; found: 321.1198. EXAMPLE 8 Preparation of 4- (benzyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step D benzyl bromide was used instead of cyclopropylmethyl bromide: ^H NMR (300 MHz, CDCI3) δ 8.85(br s, IH) , 7.3 (m, 5H) , 7.25(m, IH) , 6.8(m, 3H) , 5.3(d, J = 11Hz, IH) , 4.6(d, J = 11Hz, IH) , 1.35(m, IH) , 0.8(m, 2H) , 0.6 (m, 2H) . 19 F NMR (282 MHz, CDCI3) δ -78.08(s, 3F) . High resolution mass spec: calculated for C 2 ιHι 8 N 2 OF 5 (M+H) + : 371.1371; found: 371.1365. EXAMPLE 9 Preparation of 4- (eyelopropylmethyl) -3- (allyl) -3- (trifluoromethyl) -3,4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step C allyl magnesium bromide was used instead of lithium cyclopropyl acetylide: ^-H NMR (300 MHz, CDC1 3 ) δ 8.35 (br s, IH) , 7.1(M, 2H) , 6.85 (m, IH) , 6.75 (m, IH) , 5.9(m, IH) , 5.25(m, 2H) , 3.45(M, 2H) , 3.2 (m, IH) , 2.8 (M, IH) , 1.0 (m, IH) , 0.7 (m, IH) , 0.55(m, IH) , 0.3(m, 2H) . 19 F NMR (282 MHz, CDCI 3 ) δ -70.22(s, 3F) . High resolution mass spec: calculated for Ci 6 HιsN 2 OF 3 (M+H) + : 311.1371; found: 311.1325. EXAMPLE 10 Preparation of 4- (propargyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step D propargyl bromide was used instead of cyclopropylmethyl bromide: ^H NMR (300 MHz, CDCI 3 ) δ 9.35(br s, IH) , 7.15(m, 2H) , 6.95(m, 2H) , 4.6(dd, J= 2,18Hz, IH) , 4.4(dd, J= 2,18Hz, IH) , 2.25(t, J = 2Hz, IH) , 1.4 (m, IH) , 0.9 (m, 4H) . Anal. (Cι 7 Hι 3 N 2 OF 3 ) Calcd: C , 64 . 15 ; H , 4 . 126 ; N, 8 . 80 ; Found : C , 64 .23 ; H, 4 . 00 ; N, 8 . 61 . EXAMPLE 11 Preparation of 4- (cyclopropylethyl) -3- (2-cyclopropylethynyl) - 3- (trifluoromethyl) -3,4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step D cyclopropylethyl bromide was used instead of cyclopropylmethyl bromide: ^ NMR (300 MHz, CDC1 3 ) δ 9.2 (br s, IH) , 7.0 (m, IH) , 6.8 (M, 3H) , 4.0 (m, IH) , 3.65 (m, IH) , 1.6- 1.35(m, 3H) , 0.9(m, 3H) , 0.7(m, IH) , 0.45(m, IH) , 0.1(m, IH) . Anal. (Cι 9 Hι 9 N 2 OF 3 ) Calcd: C, 65.51; H, 5.507; N, 8.04; F, 16.36; Found: C, 65.23; H, 5.51; N, 8.05; F, 15.97. EXAMPLE 12 Preparation of 4- (isopropyl) -3- (2-eyelopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step D isopropyl iodide was used instead of cyclopropylmethyl bromide: ^H NMR (300 MHz, CDCI 3 ) δ 8.4(br s, IH) , 7.05(m, IH) , 7.0(m, IH) , 6.9(m, IH) , 6.8(m, IH) , 4.6(p, " = 7Hz, IH) , 1.45(d, J " 7Hz, 3H) , 1.4 (m, IH) , 1.2 (d, J = 7Hz, 3H) , 0.9 (m, 4H) . High resolution mass spec: calculated for Cχ 7 HιgN 2 OF 3 (M+H) + : 323.1371; found: 323.1364. EXAMPLE 13 Preparation of 6- (fluoro) -4- (allyl) -3- (n-butyl) -3- (trifluoromethyl) -3,4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step A 4-fluoro-1, 2- phenylenediamine was used instead of 1, 2-phenylenediamine, in Step C nbutyl magnesium bromide was used instead of lithium cyclopropylmethyl acetylide and in Step D allyl iodide was used instead of cyclopropylmethyl bromide: ^H NMR (300 MHz, CDC1 3 ) δ 9.2(br s, IH) , 6.65(m, IH) , 6.5 (m, 2H) , 5.8 ( , IH) , 5.35 (m, 2H) , 4.0 (m, 2H) , 2.65 (m, IH) , 2.0 (m, IH) , 1.4 (m, 4H) , 0.95(m, 3H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.60(s, 3F) , -147.85(s, IF). High resolution mass spec: calculated for Cι 6 Hι 8 NOF (M) + : 330.1335; found: 330.1332. EXAMPLE 14 Preparation of 6- (fluoro) -4- (allyl) -3- (2-cyclopropylethynyl) - 3- (trifluoromethyl) -3,4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step D allyl iodide was used instead of cyclopropylmethyl bromide: -'-H NMR (300 MHz, CDCI 3 ) δ 9.65(br s, IH) , 6.6(m, IH) , 6.5 (m, 2H) , 5.8 (m, IH) , 5.2 (m, 2H) , 4.6(m, IH) , 4.1(m, IH) , 1.4(m, IH) , 0.9(m, 4H) . 19 F NMR (282 MHz, CDC1 3 ) δ -74.62(s, 3F) , -117.46(s, IF). High resolution mass spec: calculated for Ci 7 HιsN 2 0F 4 (M+H) + : 339.1120; found: 339.1143. EXAMPLE 15 Preparation of 6- (fluoro) -4- (cyclopropylmethyl) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1: E NMR (300 MHz, CDCI 3 ) δ 9.0 (br s, IH) , 6.75 (m, 2H) , 6.55 (m, IH) , 3.8 (m, IH) , 3.35(m, IH) , 1.4(m, IH) , 1.15(m, IH) , 0.9 (m, 4H) , 0.6 (m, IH) , 0.5 (m, IH) , 0.35(m, 2H) . 19 F NMR (282 MHz, CDCI 3 ) δ -74.34(s, 3F) , -117.47(s, IF). Anal. (Cι 8 Hι 6 N 2 OF 4 1/2H 2 0) Calcd: C, 59.83; H, 4.74; N, 7.75; Found: C, 59.56; H, 4.61; N, 7.37. EXAMPLE 16 Preparation of 6- (fluoro) -4- (cyclopropylmethyl) -3- (n-butyl) - 3- (trifluoromethyl) -3,4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step C nbutyl magnesium bromide was used instead of lithium cylcopropylmethyl acetylide: !H NMR (300 MHz, CDCI 3 ) δ 96.6(br s, IH) , 6.7 (m, 2H) , 6.5(m, IH) , 3.45(m, IH) , 3.15(m, IH) , 2.75(m, IH) , 1.9 (m, IH) , 1.75 (m, IH) , 1.4 (m, 3H) , 1.05(m, IH) , 0.95(m, 3H) , 0.65 (m, 2H) , 0.35 (m, 2H) . 19 F NMR (282 MHz, CDC1 3 ) δ -73.36(s, 3F) , -117.79(s, IF). Anal. (C17H20N2OF4) Calcd: C, 59.30; H, 5.85; N, 8.145; Found: C, 58.98; H, 5.73; N, 7.90. EXAMPLE 17 Preparation of 6- (chloro) -4- (eyelopropylmethyl) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step A 4-chloro-l, 2- phenylenediamme was used instead of 1, 2-phenylenediamme: 1 H NMR (300 MHz, CDCI 3 ) δ 9.5 (br s, IH) , 6.9 (m, IH) , 6.8 (m, 2H) , 1.4(m, IH) , 1.2 (m, IH) , 0.95 ( , 4H) , 0.6(m, IH) , 0.5 (m, IH) , 0.35 ( , 2H) . 19 F NMR (282 MHz, CDCI 3 ) δ -71.80(s, 3F) . Anal. (Cι 8 Hι 6 N 2 OClF 3 ) Calcd: C, 58.62; H, 4.37; N, 7.606; F, 15.45; Cl, 9.61; Found: C, 58.27; H, 4.39; N, 7.46; F, 15.83; Cl, 9.62. EXAMPLE 18 Preparation of 6- (chloro) -4- (isobutyl) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step D isoamyl bromide was used instead of cyclopropylmethyl bromide: ^H NMR (300 MHz, CDC1 3 ) δ 9.5(br s, IH) , 6.8(m, 2H) , 6.7(m, IH) , 3.9(m, IH) , 3.6 (m, IH) , 1.7 (m, IH) , 1.6(M, IH) , 1.4 (m, 2H) , 0.95(d, J = 7Hz, 3H) , 0.9(d, J = lEz , 3H) , 0.9-0.8(m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -71.67(s, 3F) . Anal. (Cι 9 H 2 oN 2 OClF 3 ) Calcd: C, 59.30; H, 5.248; N, 7.289; F, 14.81; Cl, 9.21; Found: C, 59.12; H, 5.19; N, 7.04; F, 15.09; Cl, 9.22. EXAMPLE 19 Preparation of 6- (chloro) -4- (allyl) -3- (2-cyclopropylethynyl) - 3- (trifluoromethyl) -3 ,4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step D allyl iodide was used instead of cyclopropylmethyl bromide: ^-H NMR (300 MHz, CDCI 3 ) δ 9.65(br s, IH) , 6.8(m, 2H) , 6.75 (m, IH) , 5.8(m, IH) , 5.3 (m, 2H) , 4.6 (m, IH) , 4.1(m, IH) , 1.4 (m, IH) , 0.9 (m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -71.88(s, 3F) . Anal. (Ci 7 HιN 2 OClF 3 ) Calcd: C, 57.56; H, 3.987; N, 7.906; F, 16.07; Cl, 9.99; Found: C, 57.87; H, 4.25; N, 7.61; F, 15.93; Cl, 9.82. EXAMPLE 20 Preparation of 6- (chloro) -4-(cyclopropylmethyl) -3- (phenethyl) -3- (trifluoromethyl) -3 4-dihydro-quinoxalin-2 (IH) - one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step C phenethyl magnesium bromide was used instead of lithium cyclopropylmethyl acetylide: ^ NMR (300 MHz, CDCI 3 ) δ 8.9 (br s, IH) , 7.25 (m, 5H) , 7.)(m, IH) , 6.8 (m, IH) , 6.65 (m, IH) , 3.5(m, IH) , 3.3 (m, IH) , 3.0(m,2H), 2.75(m, IH) , 2.3(m, IH) , 1.1 (m, IH) , 0.8 (m, 2H) , 0.4 (m, 2H) . High resolution mass spec: calculated for C 2 ιH 20 N 2 OF 3 Cl (M) + : 408.1216; found: 408.1197. EXAMPLE 21 Preparation of 6- (chloro) -4- (allyl) -3- (phenethyl) -3- (trifluoromethyl) -3,4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step C phenethyl magnesium bromide was used instead of lithium cyclopropylmethyl acetylide and in Step D allyl iodide was used instead of cyclopropylmethyl bromide: ^H NMR (300 MHz, CDCI 3 ) δ 9.5 (br s, IH) , 7.25 (m, 2H) , 6.8 ( , IH) , 5.9 (m, IH) , 5.3 (m, IH) , 5. ) (m, IH) , 4.3 (m, IH) , 4.1(m, IH) , 3.1(m, IH) , 2.9-2.8 (m, 2H) , 2.3 (m, IH) . Anal. (C 20 Hι 8 N 2 OClF 3 ) Calcd: C, 60.84; H, 4.605; N, 7.105; F, 14.44; Cl, 8.989; Found: C, 61.39; H, 4.83; N, 6.68; F, 14.25; Cl, 8.89. EXAMPLE 22 Preparation of 6- (methoxy) -4- (cyclopropylmethyl) -3- (2- cyclopropylethynyl)-3-(trifluoromethyl) -3 ,4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step A 4-methoxy- 1, 2-phenylenediamine was used instead of 1,2- phenylenediamine : ^ NMR (300 MHz, CDC1 3 ) δ 8.95(br s, IH) , 6.8(m, IH) , 6.6(m, IH) , 6.4 (M, IH) , 3.9(m, IH) , 3.8 ( , 3H) , 3.4(m, IH) , 1.4 (m, IH) , 1.2 (m, IH) , 0.9 (m, 4H) , 0.6 (m, IH) , 0.45(m, IH) , 0.35(m, 2H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.19(s, 3F) . Anal. (Ci 9 Hι 9 N 2 0 2 F 3 ) Calcd: C, 62.63; H, 5.266; N, 7.698; F, 15.64; Found: C, 62.17; H, 5.36; N, 7.20; F, 14.79. EXAMPLE 23 Preparation of 6- (methoxy) -4- (allyl) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3,4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step D allyl iodide was used instead of cyclopropylmethyl bromide: ^H NMR (300 MHz, CDCI 3 ) δ 9.0(br s, IH) , 6.7 (m, IH) , 6.35(m, 2H) , 5.8(m, IH) , 5.2(m, 2H) , 4.6 (m, IH) , 4.1(M, lH),3.8(s, 3H) , 1.4 (m, IH) , 0.95(m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.44(s, 3F) . Anal. (Cι 8 Hι 7 N 2 θ 2 F 3 ) Calcd: C, 61.71; H, 4.89; N, 8.006; F, 16.27; Found: C, 62.34; H, 4.94; N, 7.81; F, 15.00. EXAMPLE 24 Preparation of 4- (cyclopropylmethyl) -3- (1-propynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step C lithium propyne was used instead of lithium cylocpropylmethyl acetylide: NMR (300 MHz, CDC1 3 ) δ 8.1(br s, IH) , 7.1 (m, IH) , 6.9 (m, IH) , 6.8 (m, IH) , 6.75 (m, IH) , 3.85(m, IH) , 3.4 (m, IH) , 2.)(s, 3H) , 1.4(m, IH) , 0.6 (m, IH) , 0.45 (m, IH) , 0.35(m, 2H) . 19 F NMR (282 MHz, CDCI 3 ) δ -71.16(s, 3F) . High resolution mass spec: calculated for CιgHi 6 N 2 OF 3 (M+H) + : 309.1214; found: 309.1224. EXAMPLE 25 Preparation of 4- (allyl) -3- (1-propynyl) -3- (trifluoromethyl) - 3, 4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 1, except that in Step C lithium propyne was used instead of lithium cyclopropylmethyl acetylide and in Step D allyl iodide was used instead of cyclopropylmethyl bromide: 3-H NMR (300 MHz, CDCI 3 ) δ 8.4 (br s, IH) , 7 . 0 (m, IH) , 6 . 8 (m, 3H) , 5 . 8 (m, IH) , 5 . 2 (m, 2H) , 4 . 6 (m, IH) , 4 . 2 (m, 1H0 , 2 . 0 ( s , 3H) . 19 F NMR ( 282 MHz , CDCl 3 ) δ -71.79(s, 3F) . High resolution mass spec: calculated for Cι 5 Hi 4 N 2 OF 3 (M+H) + : 295.1058; found: 295.1056. EXAMPLE 26 Preparation of 4- (ethoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3,4-dihydro-quinoxalin-2 (IH) -one. Step A: Preparation of compound of formula 6 wherein G - H, R2 = cyclopropylacetylene and R^ = COOEt To a solution of protected quinoxalinone of formula 3 as prepared in step C in Example 1 (147 mg, 0.42 mmol) in THF (1.5 mL) at -78°C was added nBuLi (0.31 mL, 0.5 mmol) and stirred for 5 minutes. Thereafter ethyl chloroformate (80 μL, 0.84 mmol) was added to the reaction mixture which was allowed to warm to room temperature and stir for an hour. The reaction mixture was poured onto saturated ammonium chloride and extracted with ether (3x25 mL) and the combined ether extracts were dried over anhydrous a 2 Sθ 4 and concentrated in vacuo. Chromatography (Si0 2 , 10% EtOAc- hexanes eluant) provided 122 mg of compound of formula 6, (202 mg theoretical, 60%). !H NMR (300 MHz, CDCI 3 ) δ 7.46 (m, IH) , 7.30 (m, IH) , 7.15 (m, 2H) , 5.82 (d, J = 11Hz, IH) , 5.15(d, J = 11Hz, IH) , 4.4(m, 2H) , 3.7(m, 2H) , 1.4(m, 4H) , 0.9 (m, 6H) , 0.01(s, 9H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.06(s, 3F) . Mass spec. (NH 3 -CI) : 483(M+H + , 100%). Step B: To a solution of the acylated quinoxalinone of formula 6 (84 mg, 0.17 mmol) in CH 2 C1 2 (1 mL) at room temperature was added LiBF 4 {IM in ACN, 0.85 mL, 0.85 mmol) and the resulting reaction mixture was heated to reflux for 14 hours. The reaction mixture was poured onto saturated water and extracted with ether (3x25 mL) and the combined ether extracts were dried over anhydrous Na 2 Sθ 4 and concentrated in vacuo. Chromatography (Si0 2 , 20% EtOAc-hexanes eluant) followed by a PTLC (Si0 2 , 5% EtOAc-CH 2 Cl 2 eluant) provided 15 mg of the title compound, (60 mg theoretical, 25%) . ^H NMR (300 MHz, CDC1 3 ) δ 8.06(br s, IH) , 7.35 (m, IH) , 7.05(m, 2H) , 6.8(m, IH) , 4.37 (m, 2H) , 1.4 (m, 4H) , 0.9 (m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.55(s, 3F) . High resolution mass spec: calculated for Ci 7 Hi 5 N 2 0 3 F 3 (M+H) + : 353.1113; found: 353.1093. Example 26A Preparation of 4- (ethoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3,4-dihydro-quinoxalin-2 (IH) -one. Step A: Preparation of compound of formula 12 wherein G = H. To a solution of the quinoxalinone of formula 1 as prepared in step A in Example 1 (3.55 g, 16.59 mmol) in DMF (35 mL) at room temperature was added silver carbonate (13.74 g, 49.7 mmol) follwed by PMBC1 (2.48 mL, 18.25 mmol) and the resulting reaction mixture was allowed to stir at room temperature for 14 hours protected from light by aluminum foil . The reaction mixture was filtered through Celite and the filterate washed with water. The organic layers were dried over anhydrous Na 2 S0 4 and concentrated in vacuo. Chromatography (Si0 2 , 5% EtOAc-hexanes) provided 1.28 g of compound of formula 12, (5.54 g theoretical, 23%) . ^H NMR (300 MHz, CDCI 3 ) δ 8.2(m, IH) , 7.9(m, IH) , 7.8(m, IH) , 7.46(d, J = 9Hz, 2H) , 6.93(d, J = 9Hz, 2H) , 5.59(s, 2H) , 3.81(s, 3H) . 19 F NMR (282 MHz, CDCI 3 ) δ -68.38(s, 3F) . High resolution mass spec: calculated for Cι 7 Hi 4 N 2 0 2 F 3 (M+H) + : 335.1007; found: 335.1011. Step B: Preparation of compound of formula 13 wherein G = H, R^ = cyclopropylacetylene and R l = COOEt To a solution of cyclopropylacetylene (297 μL, 2.25 mmol) in THF (5 mL) at 0°C was added nBuLi (1.25 mL, 2 mmol) and the resulting reaction mixture was allowed to stir at 0°C for 30 minutes . Thereafter the reaction mixture was cannulated to stirred solution of quinoxalinone of formula 12 (167 mg, 0.5 mmol) in THF (2.5 mL) at -78°C. The dry ice bath is removed and the reaction mixture is allowed to warm up as it stirred for an hour. Nal (300 mg, 2 mmol) was added to the reaction mixture and the resulting reaction mixture was allowed to stir at room temperature for 10 minutes. Thereafter ethyl chloroformate (478 μL, 5 mmol) was added to the reaction mixture was stirred for an additional 10 minutes. The reaction mixture is poured onto saturated NH 4 CI and extracted with ether (3x50 mL) and the combined ether extracts were dried over anhydrous Na 2 Sθ 4 and concentrated in vacuo. Chromatography (Si0 2 , 10% EtOAc-hexanes eluant) provided 78 mg of compound of formula 13, (236 mg theoretical, 33%) ^H NMR (300 MHz, CDCI 3 ) δ 7.37(d, J = 9Hz, 2H) , 7.35(m, IH) , 7.2(m, IH) , 7.15(m, 2H) , 6.9(d, J = 9Hz, 2H) , 6.90(d, J = 12Hz, IH) , 5.26(d, J " - 12Hz, IH) , 4.35 (m, 2H) , 3.81(s, IH) , 1.37(t, J = 7Hz, 3H) , 1.25 (m, IH) , 0.8 (m, 2H) , 0.6(m, 2H) . Mass spec. (NH 3 -CI) : 473(M+H) + (20%), 353 (M-PMB+H + ' 100%) . To a stirred solution of the PMB protected quinoxalinone of formula 13 (28 mg, 0.06 mmol) in CH 3 CN:H 2 0 (9:1) at room temperature was added CAN (162 mg, 0.30 mmol) and the resulting reaction mixture was allowed to stir at room temperature for one hour. The reaction mixture was poured onto water and extracted with EtOAc (3x25 mL) and the combined EtOAc extracts were dried over anhydrous Na 2 Sθ 4 and concentrated in vacuo. Chromatography (Si0 2 , 20% EtOAc- hexanes eluant) provided 16 mg of the title compound, (21 mg theoretical, 76%). 1H NMR (300 MHz, CDC1 3 ) δ 8.06(br s, IH) , 7.35 (m, IH) , 7.05(m, 2H) , 6.8 (m, IH) , 4.37 (m, 2H) , 1.4 (m, 4H) , 0.9(m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.55(s, 3F) . High resolution mass spec : calculated for C 17 H 15 N 2 O 3 F 3 (M+H) + : 353 . 1113 ; found: 353 . 1093 . EXAMPLE 27 Preparation of 4- (isopropoxycarbonyl) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3,4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 26, except that in Step A isopropyl chloroformate was used instead of ethyl chloroformate: NMR (300 MHz, CDCI 3 ) δ 8.4(br s, IH) , 7.35(m,lH), 7.15(m, IH) , 6.8(m, IH) , 5.15(p, J " = 7Hz, IH) , 1.45(m, IH) , 1.4(d, J = 7Hz, 3Hz, 3H) , 1.35 (d, J= 7Hz, 3H) , 0.85 (m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.46(s, 3F) . High resolution mass spec: calculated for Cι 8 Hι 8 N 2 0 3 F 3 (M+H) + : 367.1269; found: 367.1286. EXAMPLE 28 Preparation of 4-(propen-2-yl-oxycarbonyl)-3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 26, except that in Step A isopropenyl chloroformate was used instead of ethyl chloroformate: ^H NMR (300 MHz, CDC1 3 ) δ 8.6(br s, IH) , 7.4(m, IH) , 7.15(m, 2H) , 6.85(m, IH) , 4.85(4.87(d, J = 2Ez , IH) , 4.78(d, J= 2Hz, IH) , 2.05(s, 3H) , 1.4 (m, IH) , 0.85(m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.60(s, 3F) . High resolution mass spec: calculated for Cι 8 Hι 6 N 2 0 3 F 3 (M+H) + : 365.1113; found: 365.1100. EXAMPLE 29 Preparation of 4- (isobutoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 26, except that in Step A isobutyl chloroformate was used instead of ethyl chloroformate: ^H NMR (300 MHz, CDCI 3 ) δ 8.6(br s, IH) , 7.3 (m, IH) , 7.15 (m, IH) , 6.85 (m, IH) , 4.2 (dd, J= 7,3Hz, IH) , 3.95(dd, J = 7,3Hz, IH) , 2.1(p, J = 7Hz, IH) , 1.4(m, IH) , 0.95(d, J " = 3Hz, 3H) , 0.9(d, J = 3Hz, 3H) , 0.85 (m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.49(s, 3F) . High resolution mass spec: calculated for Cι 9 H 2 oN 2 0 3 F 3 (M+H) + : 381.1426; found: 381.1445. EXAMPLE 30 Preparation of 4- (n-butoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3,4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 26, except that in Step A nbutyl chloroformate was used instead of ethyl chloroformate: ^H NMR (300 MHz, CDC1 3 ) δ 8.65(br s, IH) , 7.3(m, IH) , 7.1(m, 2H) , 6.85(m, IH) , 4.4(m, IH) , 4.2(m, IH) , 1.65(m, 2H) , 1.45(m, 2H) , 1.4(m, IH) , 0.95(t, J " = 5Hz, 3H) , 0.85 (m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.53(s, 3F) . High resolution mass spec: calculated for Cι 9 H 20 N 2 O 3 F 3 (M+H) + : 381.1426; found: 381.1421. EXAMPLE 31 Preparation of 4- (allyloxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 26, except that in Step A allyl chloroformate was used instead of ethyl chloroformate: ^H NMR (300 MHz, CDCI 3 ) δ 8.95(br s, IH) , 7.3 (m, IH) , 7.15 (m, 2H) , 6.85(m, IH) , 6.0 ( , IH) , 5.45-5.3 (m, 2H) , 4.9-4.7(m, IH) , 1.4(m, IH) , 0.85(M, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.57(s, 3F) . High resolution mass spec: calculated for Cι 8 Hι 6 N 2 θ 3 F 3 (M+H) + : 365.1113; found: 365.1119. EXAMPLE 32 Preparation of 4- (benzyloxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3,4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 26, except that in Step A benzyl chloroformate was used instead of ethyl chloroformate: ^H NMR (300 MHz, CDC1 3 ) δ 8.6(br s, IH) , 7.4(m, 5H) , 7.3(m, IH) , 7.15(m, 2H) , 6.85(, IH) , 5.45-5.2 (m, 3H) , 1.35 (m, IH) , 0 . 75 (m, 4H) . 19 F NMR ( 282 MHz , CDCI 3 ) δ -73 . 54 (s , 3F) . High resolution mass spec : calculated for C 22 Hι 8 N 2 θ 3 F 3 (M+H) + : 415 . 1284 ; found: 415 . 1269 . EXAMPLE 33 Preparation of 4- (n-propylsulfonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3,4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 40, except that in Step A n-propylsulfonyl chloride was used instead of isopropylsulfonyl chloride: !H NMR (300 MHz, CDCI 3 ) δ 8.1(br s, IH) , 7.4(m, IH) , 7.2 (m, IH) , 7.15 (m, IH) , 6.85 (M, IH) , 3.65(m, IH) , 3.3(m, IH) , 2.0 (m, 2H) , 1.45 (m, IH) , l.l(t, J = 7Hz, 3H) , 0.9(m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.17(s, 3F) . High resolution mass spec: calculated for Ci 7 Hι 8 N0 3 F 3 S (M+H) + : 387.0990; found: 387.0996. EXAMPLE 34 Preparation of 4- (phenylcarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3,4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 37, except that in Step A benzoyl chloride was used instead of isobutyryl chloride: ^H NMR (300 MHz, CDC1 3 ) δ 8.2(br s, IH) , 7.55 ( , 2H) , 7.45(m, IH) , 7.3(m, 2H) , 7.)(m, IH) , 6.85 (M, IH) , 6.75 (m, IH) , 6.9 (m, IH) , 1.35 ( , IH) , 0.8(m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -72.16(s, 3F) . High resolution mass spec: calculated for C 2 ιHχ 6 N 2 0F 3 (M+H) + : 385.1163; found: 385.1184. EXAMPLE 35 Preparation of 4- ( eopentyl-oxycarbonyl) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 26, except that in Step A neopentyl chloroformate was used instead of ethyl chloroformate: ^H NMR (300 MHz, CDCI 3 ) δ 8.55(br s, IH) , 7.3 (m, IH) , 7.15(m, 2H) , 6.85(m, IH) , 4.3 (d, J = 11Hz, IH) , 3.8(d, J = 11Hz, IH) , 1.4(m, IH) , 1.0(s, 9H) , 0.85 (m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.42(s, 3F) . High resolution mass spec: calculated for C 20 H 22 N 2 O 3 F 3 (M+H) + : 395.1582; found: 395.1587. EXAMPLE 36 Preparation of 4- (2-propynyl-oxycarbonyl) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 26, except that in Step A propargyl chloroformate was used instead of ethyl chloroformate: ^H NMR (300 MHz, CDC1 3 ) δ 9.0(br s, IH) , 7.35 (m, IH) , 7.15 (m, 2H) , 6.9(m, IH) , 4.95 (dd, J = 2,13Hz, IH) , 4.85(dd, J - 2,13Hz, IH) , 2.95(t, J = 2Hz, IH) , 1.4(m, IH) , 0.85(m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.62(s, 3F) . Anal. (Cι 7 Hi 3 N 2 0 3 F 3 ) Calcd: C, 59.637; H, 3.626; N, 7.73; F, 15.76; Found: C, 60.18; N, 3.84, N, 7.38; F, 15.66. EXAMPLE 37 Preparation of 4- (isopropylcarbonyl) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro- quinoxalin-2 (IH) -one. Step A: Preparation of compound of formula 10 wherein G = H, R2 = cyclopropylacetylene and R^- = COiPr To a solution of protected quinoxalinone of formula 3 as prepared in step C in Example 1 (250 mg, 0.61 mmol) in THF (2.5 mL) at -78°C was added nBuLi (0.53 mL, 0.85 mmol) followed by isobutyryl chloride (0.15 mL, 1.46 mmol) and the resulting reaction mixture was allowed to stir for an hour with warming to room temperature. The reaction mixture is poured onto saturated NH 4 CI and extracted with ether (3x50mL) and the combined ether extracts were dried over anhydrous N 2 Sθ 4 and concentrated in vacuo. Chromatography (Si0 2 , 5% EtOAc-hexanes eluant) provided 189 mg of compound of formula 10, (293 mg theoretical, 64%) . !H NMR (300 MHz, CDC1 3 ) δ 7.5(m, IH) , 7.2 (m, 2H) , 6.9 (m, IH) , 5.85(d, J = 11Hz, IH) , 5.29d, J = 11Hz, IH) , 3.7(m, 2H) , 3.15 (m, IH) , 1.4(m, IH) , 1.31(d, J " = 7Hz, 3H) , 1.13(d, J = 7Hz, 3H) , 0.95(m, 2H) , 0.85(M, 4H) . Mass spec. (NH 3 -CI) : 481(M+H + , 100%). Step B: To a solution of the acylated quinoxalinone of formula 10 (189 mg, 0.39 mmol) in CH 2 C1 2 (2 mL) at 0°C was added BF 3 .Et 2 0 (110 μL, 0.87 mmol) and the resulting reaction mixture was allowed to stir at 0°C for 30 minutes and stirred for an additional hour with warming to room temperature.. To the reaction mixture was added MeOH (1 mL) and 15% NaOH (1 mL) and the resulting reaction mixture was allowed to stir at room temperature for 10 minutes . The reaction mixture was poured onto water and extracted with CH 2 C1 (3x25 mL) and the combined CH 2 C1 2 extracts were dried over anhydrous a 2 Sθ 4 and concentrated in vacuo. Chromatography (Si0 2 , 25% acetone- hexanes eluant) followed by PTLC (Siθ 2 , CH 2 Cl 2 eluant) provided 10.5 mg of the title compound, (136.5 mg theoretical, 7.7%). !H NMR (300 MHz, CDCI 3 ) δ 8.65(br s, IH) , 7.15 ( , 2H) , 6.95 (m, 2H) , 3.15 (m, IH) , 1.4 (m, IH) , 1.28 (d, J = 7Hz, 3H) , l.ll(d, J = 7Hz, 3H) , 0.8 (m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -72.78(s, 3F) . High resolution mass spec: calculated for Cι 8 Hι 8 N 2 0 2 F 3 (M+H) + : 351.1320; found: 351. 1299. EXAMPLE 38 Preparation of 4- (cyclopropylcarbonyl) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro- quinoxalin-2 ( IH) -one . The title compound was prepared in a manner similar to the product of Example 37, except that in Step A cyclopropane carbonyl chloride was used instead of isobutyryl chloride: ^H NMR (300 MHz, CDCI3) δ 8.6 (br s, IH) , 7.35 (m, IH) , 7.2-7.0(m, 2H) , 6.9(m, IH) , 1.95(m, IH) , 1.35(m, 2H) , 1.2(m, IH) , 1.0 (m, IH) , 0.9 (m, IH) , 0.85 (m, 4H) . High resolution mass spec: calculated for Cι 8 H 16 N 2 0 2 F 3 (M+H) + : 349.1163; found: 349.1153. EXAMPLE 39 Preparation of 4- (ethylsulfonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 40, except that in Step A ethylsulfonyl chloride was used instead of isopropylsulfonyl chloride: 3-H NMR (300 MHz, CDCI3) δ 8.8 (br s, IH) , 7.4(m, IH) , 7.25 (m, IH) , 7.15 (m, IH) , 6.9(m, IH) , 3.75(p, J = 7Hz, IH) , 3.45(p, J = 7Hz, IH) , 1.5(t, J = 7Hz, 3H) , 1.4(m, IH) , 0.9 (m, 4H) . 19 F NMR (282 MHz, CDCI3) δ -73.13 (s, 3F) . High resolution mass spec: calculated for C16H16N2O3F3S (M+H) + : 373.0833; found: 373.0829. EXAMPLE 40 Preparation of 4- (isopropylsulfonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one. Step A: Preparation of compound of formula 8. wherein G = H, R2 = cyclopropylacetylene and R^ = SOOiPr To a solution of protected quinoxalinone of formula 3 as prepared in step C in Example 1 (250 mg, 0.61 mmol) in THF (2.5 mL) at -78°C was added nBuLi (0.53 mL, 0.85 mmol) followed by isopropylsulfonyl chloride (164 μL, 1.46 mmol) and the reaction mixture was allowed to warm to room temperature and stir for an hour. The reaction mixture was poured onto saturated NaHC0 3 and extracted with ether (3x25 mL) and the combined ether extracts were dried over anhydrous Na S0 4 and concentrated in vacuo. Chromatography (Si0 2 , 10% EtOAc-hexanes eluant) provided 51 mg of compound of formula 8, (315 mg theoretical, 16%) . !H NMR (300 MHz, CDC1 3 ) δ 7.5(m, IH) , 7.35(m, 2H) , 7.2 ( , IH) , 5.8(d, J = 11Hz, IH) , 5.15(d, J = 11Hz, IH) , 4.25(m lH), 3.7(m, 2H) , 1.65 (m, 3H) , 1.45(m, 4H) , 0.95 (m, 5H) , 0.01(s, 9H) . Mass spec. (NH 3 -CI) : 534(M+NH + , 100%) . Step B: To a solution of the sulfonamide-quinoxalinone of formula 8 . (51 mg, 0.099 mmol) in CH 2 C1 2 (1 mL) at 0°C was added BF 3 .Et 2 0 (27 μL, 0.22 mmol) and the resulting reaction mixture was allowed to stir at 0°C for 30 minutes, and stirred for an additional 1 hour with warming to room temperature. To the reaction mixture was added MeOH (1 mL) and 15% NaOH (1 mL) and the resulting reaction mixture was allowed to stir at room temperature for 10 minutes. The reaction mixture was poured onto water and extracted with CH 2 C1 (3x25 mL) and the combined CH 2 C1 2 extracts were dried over anhydrous Na 2 S0 4 and concentrated in vacuo. Chromatography/PTLC (Si0 2 , 25% acetone-hexanes eluant) provided 14 mg of the title compound, (38 mg theoretical, 37%). 3-H NMR (300 MHz, CDCI 3 ) δ 8.63 (br s, IH) , 7.4 (m, IH) , 7.25(m, IH) , 7.15(m, IH) , 6.85(m, IH) , 4.2(m, IH) , 1.6(d, J = 7Hz, 3H) , 1.45(m, IH) , 1.39(d, J = 7Hz, 3H) , 0.9(m, 4H) . 19 F NMR (282 MHz, CDC1 3 ) δ -73.05(s, 3F) . High resolution mass spec: calculated for Ci 7 Hι 8 N 2 θ 3 F 3 S (M+H) + : 387.0990; found: .387.1002. EXAMPLE 41 Preparation of 4- (methoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 26, except that in Step A methyl chloroformate was used instead of ethyl chloroformate: ^H NMR (300 MHz, CDCI 3 ) δ 8.45(br s, IH) , 7.25(m, IH) , 7.05(m, 2H) , 6.85(m, IH) , 8.85(s, #J) , 1.4(m, IH) , 0.85(m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.65(s, 3F) . High resolution mass spec: calculated for Cι 6 Hi 4 N 2 θ 3 F 3 (M+H) + : 339.0956; found: 339.0932. EXAMPLE 42 Preparation of 6- (chloro) -4- (ethoxycarbonyl) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3,4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 26: X H NMR (300 MHz, CDCI 3 ) δ 8.65 (br s, IH) , 7.35(m, IH) , 7.1(m, IH) , 6.8(m, IH) , 4.45-4.3(m, 2H) , 1.4(t, J = 7Hz, 3H) , 1.35(m, IH) , 0.85(m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.54(s, 3F) . High resolution mass spec: calculated for Cι 7 H 13 N 2 θ 3 F 3 Cl (M-H) + : 385.0566; found: 385.0570. EXAMPLE 43 Preparation of 6- (chloro) -4- (isopropoxycarbonyl) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 26, except that in Step A isopropyl chloroformate was used instead of ethyl chloroformate: ^-H NMR (300 MHz, CDCI 3 ) δ 8.65(br s, IH) , 7.45(m, IH) , 7.35(m, IH) , 15 (m, IH) , 6.8 (m, IH) , 5.15 (p, J " = 7Hz, IH) , 1.4(d, J = 7Hz, 3H) , 1.38(d, J = 7Hz, 3H) , 1.35(m, IH) , 0.85 (m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.47(s, 3F) . High resolution mass spec: calculated for Cι 8 H 15 N 2 θ 3 F 3 Cl (M-H) + : 399.0723; found: 399.0719. EXAMPLE 44 Preparation of 6- (chloro) -4- (propen-2-yl-oxycarbonyl) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3,4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 26, except that in Step A isopropenyl chloroformate was used instead of ethyl chloroformate: ^H NMR (300 MHz, CDCI 3 ) δ 8.8(br s, IH) , 7.4(m, IH) , 7.15(m, IH) , 6.8 (m, IH) , 4.9(m, IH) , 4.8 (m, IH) , 2.05(s, 3H) , 1.4 (m, IH) , 0.85 (m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.60(s, 3F) . High resolution mass spec: calculated for Cι 8 Hi 3 N 2 θ 3 F 3 Cl (M-H) + : 397.0566; found: 397.0563. EXAMPLE 45 Preparation of 6- (fluoro) -4- (ethoxycarbonyl) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 26: H NMR (300 MHz, CDCI 3 ) δ 8.7 (br s, IH) , 7. l(m, IH) , 6.8(m, 2H) , 4.4(m, 2H) , 1.42(t, J = 7Hz, 3H) , 1.4(m, IH) , 0.85 (m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.54(s, 3F) , -117.47 (s, IF). High resolution mass spec: calculated for C 17 H 13 N 2 O 3 F 4 (M-H) + : 369.0862; found: 369.0852. EXAMPLE 46 Preparation of 6- (fluoro) -4- (isopropoxycarbony1) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 26, except that in Step A isopropyl chloroformate was used instead of ethyl chloroformate: ^H NMR (300 MHz, CDCI 3 ) δ 8.85(br s, IH) , 7.15 (m, IH) , 6.8(m, 2H) , 5.15(p, J " = 7Hz, IH) , 1.45(d, J = 7Hz, 3H) , 1.42(d, J = 7Hz, 3H) , 1.4(m, IH) , 0.85(m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.45(s, 3F) , -117.63(s, IF). High resolution mass spec: calculated for Cι 8 Hι 5 N 2 θ 3 F 4 (M-H) + : 385.1018; found: 383.1045. EXAMPLE 47 Preparation of 6- (fluoro) -4-(propen-2-yl-oxycarbonyl) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3,4-dihydro- quinoxalin-2 (IH) -one. The title compound was prepared in a manner similar to the product of Example 26, except that in Step A isopropenyl chloroformate was used instead of ethyl chloroformate: ^H NMR (300 MHz, CDCI 3 ) δ 9.0(br s, IH) , 7.2(m, IH) , 6.85(m, 2H) , 4.9(m, IH) , 4.8(m, IH) , 2.05(s, 3H) , 1.4 (m, IH) , 0.85(m, 4H) . 19 F NMR (282 MHz, CDCI 3 ) δ -73.61(s, 3F) , -117.10(s, IF). High resolution mass spec: calculated for Cι 8 Hi 5 N 2 θ 3 F 4 (M+H) + : 383.1018; found: 383.1018. Table 1 *Unless otherwise noted, stereochemistry is (+/-). Tables 2 and 3 show representative compounds of the present invention. Each formula shown at the start of Table 2 and 3 is intended to be paired with each entry in the table which follows . Table 2 s Table 2 cont * 2-Fur stands for furan-2-yl * 3-Fur stands for furan-3-yl * 2-Imid stands for imidazol-2-yl * 5-Imid stands for imidazol-5-yl Table 2 cont , Table 2 cont. Table 2 cont . Table 2 cont. Table 2 cont . Table 2 cont . Table 2 cont , Table 2 cont. Table 2 co t. Table 2 cont . Table 2 cont. Table 2 cont . Table 2 cont. Table 2 cont . Table 2 con . Table 2 cont. Table 2 cont . Table 2 cont . Table 2 cont. Table 2 cont . Table 2 cont . Table 2 cont . Table 2 cont. Table 2 cont . Table 2 cont . Table 2 cont. Table 2 cont . Table 2 cont . *Unless otherwise noted, stereochemistry is (+/-) and in R 2 all double bonds are trans . Table 3 m n p q C1 r s t u x y Table 3 cont . Ex.# R l R2 4001 -CH 2 -CH=CH 2 n-butyl 4002 -CH 2 -CH=CH 2 benzyl 4003 -CH 2 -CH=CH 2 phenethyl 4004 -CH 2 -CH=CH 2 -CH 2 CH 2 -cycPr 4005 -CH 2 -CH=CH 2 -C≡C-CH 3 4006 -CH 2 -CH=CH 2 -C≡C-CF 3 4007 -CH 2 -CH=CH 2 -C≡C-Et 4008 -CH 2 -CH=CH 2 -C≡C-iPr 4009 -CH 2 -CH=CH 2 -C≡C-cycPr 4010 -CH 2 -CH=CH 2 -C≡C-1- (Me) cycPr 4011 -CH 2 -CH=CH 2 -C≡C-CH=CH 2 4012 -CH -CH=CH 2 -CH=CH-CH 3 4013 -CH 2 -CH=CH 2 -CH=CH-CF 3 4014 -CH 2 -CH=CH 2 -CH=CH-Et 4015 -CH 2 -CH=CH 2 -CH=CH-iPr 4016 -CH 2 -CH=CH 2 -CH=CH-cycPr 4017 -CH 2 -CH=CH 2 -CH=CH-CH=CH 2 4018 -CH 2 -CH=CH 2 -CH 2 -C≡C-CH 3 4019 -CH 2 -CH=CH 2 -CH 2 -C≡C-CF 3 4020 -CH 2 -CH=CH 2 -CH 2 -C≡C-Et 4021 -CH 2 -CH=CH -CH 2 -C≡C-iPr 4022 -CH 2 -CH=CH 2 -CH 2 -C≡C-cycPr 4023 -CH 2 -CH=CH 2 -CH 2 -C≡C-CH=CH 2 4024 -CH 2 -CH=CH 2 -CH 2 -CH=CH 2 4025 -CH 2 -CH=CH 2 -CH 2 -CH=CH-CH 3 4026 -CH 2 -CH=CH 2 -CH 2 -CH=CH-CF 4027 -CH 2 -CH=CH -CH 2 -CH=CH-Et 4028 -CH 2 -CH=CH 2 -CH 2 -CH=CH-iPr 4029 -CH 2 -CH=CH 2 -CH 2 -CH=CH-cycPr 4030 -CH 2 -CH=CH 2 -CH 2 -CH=CH-CH=CH 2 4031 -CH 2 -CH=CH 2 -CH 2 -CH=C(CH 3 ) 2 4032 -CH 2 -CH=CH -CH=CH-CH 2 -cycPr 4033 -CH 2 -CH=CH 2 n-butyl 4034 -CH2-cycPr benzyl 4035 -CH2~cycPr phenethyl 4036 -CH -cycPr -CH2CH 2 -cycPr 4037 -CH2~cycPr -C≡C-CH 3 4038 -CH2-cycPr -C≡C-CF 3 4039 -CH2~cycPr -C≡C-Et 4040 -CH -cycPr -C≡C-iPr 4041 -CH 2 -cycPr -C≡C-cycPr 4042 -CH2~cycPr -C≡C-1- (Me) cycPr 4043 -CH2-cycPr -C≡C-CH=CH 2 4044 -CH2-cycPr -CH=CH-CH 3 4045 -CH2-cycPr -CH=CH-CF 3 4046 -CH2-cycPr -CH=CH-Et 4047 -CH2~cycPr -CH=CH-iPr 4048 -CH2-cycPr -CH=CH-cycPr 4049 -CH2-cycPr -CH=CH-CH=CH 2 4050 -CH2-cycPr -CH 2 -C=C-CH 4051 -CH2-cycPr -CH 2 -C≡C-CF 3 4052 -CH2-cycPr -CH 2 -C≡C-Et 4053 -CH2~cycPr -CH 2 -C≡C-iPr 4054 -CH2-cycPr -CH 2 -C≡C-cycPr 4055 -CH2-cycPr -CH 2 -C≡C-CH=CH 2 4056 -CH2~cycPr -CH 2 -CH=CH 2 4057 -CH2-cycPr -CH 2 -CH=CH-CH 4058 -CH2-cycPr -CH 2 -CH=CH-CF 3 4059 -CH2-cycPr -CH 2 -CH=CH-Et 4060 -CH2-cycPr -CH 2 -CH=CH-iPr 4061 -CH2-cycPr -CH 2 -CH=CH-cycPr 4062 -CH2-cycPr -CH 2 -CH=CH-CH=CH 2 4063 -CH2-cycPr -CH 2 -CH=C(CH 3 ) 2 4064 -CH2-cycPr -CH=CH-CH 2 -cycPr 4065 -C0 2 CH 2 CH 3 n-butyl 4066 -C0 2 CH 2 CH 3 benzyl 4067 -C0 2 CH 2 CH 3 phenethyl 4068 -C0 2 CH 2 CH 3 -CH 2 CH 2 -cycPr 4069 -CO2CH2CH3 -C≡C-CH 3 4070 -CO2CH2CH3 -C≡C-CF 3 4071 -C0 2 CH 2 CH 3 -C≡C-Et 4072 -CO2CH2CH3 -C≡C-iPr 4073 -C0 2 CH 2 CH 3 -C≡C-cycPr 4074 -C0 2 CH 2 CH 3 -C≡C-1- (Me) cycPr 4075 -C0 2 CH 2 CH 3 -C≡C-CH=CH 2 4076 -C0 2 CH 2 CH 3 -CH=CH-CH 3 4077 -C0 2 CH 2 CH 3 -CH=CH-CF 3 4078 -CO2CH2CH3 -CH=CH-Et 4079 -CO2CH2CH3 -CH=CH-iPr 4080 -C0 2 CH 2 CH 3 -CH=CH-cycPr 4081 -CO2CH2CH3 -CH=CH-CH=CH 2 4082 -C0 2 CH 2 CH 3 -CH 2 -C≡C-CH 3 4083 -C0 2 CH 2 CH 3 -CH 2 -C≡C-CF 3 4084 -CO2CH2CH3 -CH 2 -C≡C-Et 4085 -CO2CH2CH3 -CH 2 -C≡C-iPr 4086 -CO2CH2CH3 -CH 2 -C≡C-cycPr 4087 -C0 2 CH 2 CH 3 -CH 2 -C≡C-CH=CH 4088 -C0 2 CH 2 CH 3 -CH 2 -CH=CH 2 4089 -C0 2 CH 2 CH 3 -CH 2 -CH=CH-CH 3 4090 -CO2CH2CH3 -CH 2 -CH=CH-CF 3 4091 -C0 2 CH 2 CH 3 -CH 2 -CH=CH-Et 4092 -C0 2 CH 2 CH 3 -CH 2 -CH=CH-iPr 4093 -CO2CH2CH3 -CH 2 -CH=CH-cycPr 4094 -C0 2 CH 2 CH 3 -CH 2 - CH=CH -CH=CH 2 4095 -CO2CH2CH3 -CH 2 -CH=C(CH 3 ) 2 4096 -CO2CH2CH3 -CH=CH-CH -cycPr 4097 -C0 2 CH(CH 3 ) 2 n-butyl 4098 -C0 2 CH(CH 3 ) 2 benzyl 4099 -C0 2 CH(CH 3 ) 2 phenethyl 4101 -C0 CH(CH 3 )2 -CH 2 CH 2 -cycPr 4102 -C0 2 CH(CH 3 ) 2 -C≡C-CH 3 4103 -C0 2 CH(CH 3 ) 2 -C≡C-CF 3 4104 -C0 2 CH(CH 3 )2 -C≡C-Et 4105 -C0 2 CH(CH 3 ) 2 -C≡C-iPr 4106 -C0 2 CH(CH )2 -C≡C-cycPr 4107 -C0 2 CH(CH 3 )2 -C≡C-1- (Me) cycPr 4108 -C0 2 CH(CH 3 ) 2 -C≡C-CH=CH 2 4109 -C0 2 CH(CH 3 ) 2 -CH=CH-CH 3 4110 -C0 2 CH(CH 3 ) 2 -CH=CH-CF 3 4111 -C0 CH(CH 3 )2 -CH=CH-Et 4112 -C0 2 CH(CH3) 2 -CH=CH-iPr 4113 -C0 2 CH(CH 3 )2 -CH=CH-cycPr 4114 -C0 2 CH(CH 3 ) 2 -CH=CH-CH=CH 2 4115 -C0 2 CH(CH 3 ) 2 -CH 2 -C≡C-CH 3 4116 -C0 2 CH(CH 3 )2 -CH 2 -C≡C-CF 3 4117 -C0 2 CH(CH 3 ) 2 -CH 2 -C≡C-Et 4118 -C0 2 CH(CH 3 ) 2 -CH 2 -C≡C-iPr 4119 -C0 2 CH(CH 3 )2 -CH2 -C≡C-cycPr 4120 -C0 2 CH(CH 3 )2 -CH 2 -C≡C-CH=CH 2 4121 -C0 2 CH(CH 3 )2 -CH 2 -CH=CH 2 4122 -C0 2 CH(CH 3 ) 2 -CH 2 -CH=CH-CH 3 4123 -C0 2 CH(CH 3 ) 2 -CH 2 -CH=CH-CF 3 4124 -C0 2 CH(CH 3 ) 2 -CH 2 -CH=CH-Et 4125 -C0 CH(CH 3 )2 -CH 2 -CH=CH-iPr 4126 -C0 2 CH(CH 3 ) 2 -CH 2 -CH=CH-cycPr 4127 -C0 2 CH(CH 3 ) 2 -CH 2 -CH=CH-CH=CH 2 4128 -C0 2 CH(CH 3 )2 -CH 2 -CH=C(CH 3 ) 2 4129 -C0 2 CH(CH 3 ) 2 -CH=CH-CH 2 -cycPr 4130 -C0 2 C(=CH 2 )CH 3 n-butyl 4131 -C0 2 C(=CH 2 )CH 3 benzyl 4132 -C0 2 C(=CH 2 )CH 3 phenethyl 4133 -C0 2 C(=CH 2 )CH 3 -CH 2 CH 2 -cycPr 4134 -C0 2 C(=CH 2 )CH 3 -C≡C-CH 3 4135 -C0 C(=CH 2 )CH3 -C≡C-CF 3 4136 -C0 2 C(=CH 2 )CH 3 -C≡C-Et 4137 -C0 2 C(=CH 2 )CH 3 -C≡C-iPr 4138 -C0 2 C(=CH 2 )CH 3 -C≡C-cycPr 4139 -C0 2 C(=CH 2 )CH 3 -C≡C-1- (Me) cycPr 4140 -C0 2 C(=CH 2 )CH 3 -C≡C-CH=CH 2 4141 -C0 2 C(=CH 2 )CH 3 -CB=CH-CH 3 4142 -C0 2 C(=CH 2 )CH 3 -CH=CH-CF 3 4143 -C0 2 C(=CH 2 )CH 3 -CH=CH-Et 4144 -C0 2 C(=CH 2 )CH 3 -CH=CH-iPr 4145 -C0 2 C(=CH 2 )CH 3 -CH=CH-cycPr 4146 -C0 2 C(=CH 2 )CH3 -CH=CH-CH=CH 4147 -C0 2 C(=CH )CH3 -CH 2 -C≡C-CH 3 4148 -C0 2 C(=CH 2 )CH 3 -CH 2 -C≡C-CF 3 4149 -C0 C(=CH 2 )CH3 -CH 2 -C≡C-Et 4150 -C0 C(=CH 2 )CH3 -CH 2 -C≡C-iPr 4151 -C0 2 C(=CH 2 )CH 3 -CH2-C≡C-cycPr 4152 -C0 2 C(=CH 2 )CH 3 -CH 2 -C≡C-CH=CH 2 4153 -C0 2 C(=CH 2 )CH 3 -CH 2 -CH=CH 2 4154 -C0 2 C(=CH 2 )CH 3 -CH 2 -CH=CH-CH 3 4155 -C0 2 C(=CH 2 )CH3 -CH 2 -CH=CH-CF 3 4156 -C0 2 C(=CH 2 )CH3 -CH 2 -CH=CH-Et 4157 -C0 2 C(=CH 2 )CH 3 -CH 2 -CH=CH-iPr 4158 -C0 2 C(=CH 2 )CH 3 -CH 2 -CH=CH-cycPr 4159 -C0 2 C(=CH 2 )CH 3 -CH 2 -CH=CH-CH=CH 2 4160 -C0 2 C(=CH 2 )CH 3 -CH 2 -CH=C(CH 3 ) 2 4161 -C0 2 C(=CH 2 )CH 3 -CH=CH-CH 2 -cycPr 4162 -C(=0) -cycPr n-butyl 4163 -C(=0) -cycPr benzyl 4164 -C(=0) -cycPr phenethyl 4165 -C(=0) -cycPr -CH 2 CH 2 -cycPr 4166 -C(=0) -cycPr -C≡C-CH 3 4167 -C(=0) -cycPr -C≡C-CF 4168 -C(=0) -cycPr -C≡C-Et 4169 -cycPr -C≡C-iPr 4170 -cycPr -C≡C-cycPr 4171 -cycPr -C≡C-1- (Me) cycPr 4172 -cycPr -C≡C-CH=CH 2 4173 -cycPr -CH=CH-CH 3 4174 -cycPr -CH=CH-CF 3 4175 -cycPr -CH=CH-Et 4176 -cycPr -CH=CH-iPr 4177 -cycPr -CH=CH-cycPr 4178 -cycPr -CH=CH-CH=CH 2 4179 -cycPr -CH 2 -C=C-CH 3 4180 -cycPr -CH 2 -C≡C-CF 3 4181 -cycPr -CH -C≡C-Et 4182 -cycPr -CH 2 -C≡C-iPr 4183 -cycPr -CH 2 -C≡C-cycPr 4184 -cycPr -CH 2 -C≡C-CH=CH 2 4185 -cycPr -CH 2 -CH=CH 2 4186 -cycPr -CH 2 -CH=CH-CH 4187 -cycPr -CH 2 -CH=CH-CF 3 4188 -cycPr -CH 2 -CH=CH-Et 4189 -cycPr -CH 2 -CH=CH-iPr 4190 -cycPr -CH 2 -CH=CH-cycPr 4191 -cycPr -CH 2 -CH=CH-CH=CH 2 4192 -cycPr -CH 2 -CH=C(CH 3 ) 2 4193 -cycPr -CH=CH-CH 2 -cycPr *Unless otherwise noted, stereochemistry is (+/-) and in R 2 , all double bonds are trans . Utility The compounds of this invention possess reverse transcriptase inhibitory activity, in particular, HIV inhibitory efficacy. The compounds of formula (I) possess HIV reverse transcriptase inhibitory activity and are therefore useful as antiviral agents for the treatment of HIV infection and associated diseases. The compounds of formula (I) possess HIV reverse transcriptase inhibitory activity and are effective as inhibitors of HIV growth. The ability of the compounds of the present invention to inhibit viral growth or infectivity is demonstrated in standard assay of viral growth or infectivity, for example, using the assay described below. The compounds of formula (I) of the present invention are also useful for the inhibition of HIV in an ex vivo sample containing HIV or expected to be exposed to HIV. Thus, the compounds of the present invention may be used to inhibit HIV present in a body fluid sample (for example, a serum or semen sample) which contains or is suspected to contain or be exposed to HIV. The compounds provided by this invention are also useful as standard or reference compounds for use in tests or assays for determining the ability of an agent to inhibit viral clone replication and/or HIV reverse transcriptase, for example in a pharmaceutical research program. Thus, the compounds of the present invention may be used as a control or reference compound in such assays and as a quality control standard. The compounds of the present invention may be provided in a commercial kit or container for use as such standard or reference compound. Since the compounds of the present invention exhibit specificity for HIV reverse transcriptase, the compounds of the present invention may also be useful as diagnostic reagents in diagnostic assays for the detection of HIV reverse transcriptase. Thus, inhibition of the reverse transcriptase activity in an assay (such as the assays described herein) by a compound of the present invention would be indicative of the presence of HIV reverse transcriptase and HIV virus . As used herein "μg" denotes microgram, "mg" denotes milligram, "g" denotes gram, "μL" denotes microliter, "mL" denotes milliliter, "L" denotes liter, "nM" denotes nanomolar, "μM" denotes micromolar, "mM" denotes millimolar, "M" denotes molar and "nm" denotes nanometer. "Sigma" stands for the Sigma-Aldrich Corp. of St. Louis, MO. HIV RNA Assay DNA Plasmids and in vi tro RNA transcripts; Plasmid pDAB 72 containing both gag and pol sequences of BHlO (bp 113-1816) cloned into PTZ 19R was prepared according to Erickson-Viitanen et al . AIDS Research and Human Retroviruses 1989, 5, 577. The plasmid was linearized with Bam HI prior to the generation of in vi tro RNA transcripts using the Riboprobe Gemini system II kit (Promega) with T7 RNA polymerase. Synthesized RNA was purified by treatment with RNase free DNAse (Promega) , phenol-chloroform extraction, and ethanol precipitation. RNA transcripts were dissolved in water, and stored at -70°C. The concentration of RNA was determined from the A 2 go- Probes : Biotinylated capture probes were purified by HPLC after synthesis on an Applied Biosystems (Foster City, CA) DNA synthesizer by addition of biotin to the 5 ' terminal end of the oligonucleotide, using the biotin-phosphoramidite reagent of Cocuzza, Tet . Lett . 1989, 30, 6287. The gag biotinylated capture probe (5-biotin-CTAGCTCCCTGCTTGCCCATACTA 3') was complementary to nucleotides 889-912 of HXB2 and the pol biotinylated capture probe (5 '-biotin -CCCTATCATTTTTGGTTTCCAT 3' ) was complementary to nucleotides 2374-2395 of HXB2. Alkaline phosphatase conjugated oligonucleotides used as reporter probes were prepared by Syngene (San Diego, CA.) . The pol reporter probe (5' CTGTCTTACTTTGATAAAACCTC 3') was complementary to nucleotides 2403-2425 of HXB2. The gag reporter probe (5 ' CCCAGTATTTGTCTACAGCCTTCT 3 ' ) was complementary to nucleotides 950-973 of HXB2. All nucleotide positions are those of the GenBank Genetic Sequence Data Bank as accessed through the Genetics Computer Group Sequence Analysis Software Package (Devereau Nucleic Acids Research 1984, 12, 387). The reporter probes were prepared as 0.5 uM stocks in 2 x SSC (0.3 M NaCl, 0.03 M sodium citrate), 0.05 M Tris pH 8.8, 1 mg/mL BSA. The biotinylated capture probes were prepared as 100 μM stocks in water. Streptavidin coated plates; Streptavidin coated plates were obtained from Du Pont Biotechnology Systems (Boston, MA) . Cells and virus stocks; MT-2 and MT-4 cells were maintained in RPMI 1640 supplemented with 5% fetal calf serum (FCS) for MT-2 cells or 10% FCS for MT-4 cells, 2 mM L-glutamine and 50 μg/mL gentamycin, all from Gibco. HIV-1 RF was propagated in MT-4 cells in the same medium. Virus stocks were prepared approximately 10 days after acute infection of MT-4 cells and stored as aliquots at -70°C. Infectious titers of HIV-1 (RF) stocks were 1-3 x 10^ PFU (plaque forming units) /mL as measured by plaque assay on MT-2 cells (see below) . Each aliquot of virus stock used for infection was thawed only once. For evaluation of antiviral efficacy, cells to be infected were subcultured one day prior to infection. On the day of infection, cells were resuspended at 5 x 10^ cells/mL in RPMI 1640, 5% FCS for bulk infections or at 2 x 10 6 /mL in Dulbecco's modified Eagles medium with 5% FCS for infection in microtiter plates. Virus was added and culture continued for 3 days at 37°C. HIV RNA assay; Cell lysates or purified RNA in 3 M or 5 M GED were mixed with 5 M GED and capture probe to a final guanidinium isothiocyanate concentration of 3 M and a final biotin oligonucleotide concentration of 30 nM. Hybridization was carried out in sealed U bottom 96 well tissue culture plates (Nunc or Costar) for 16-20 hours at 37°C. RNA hybridization reactions were diluted three-fold with deionized water to a final guanidinium isothiocyanate concentration of 1 M and aliquots (150 μL) were transferred to streptavidin coated microtiter plates wells. Binding of capture probe and capture probe-RNA hybrid to the immobilized streptavidin was allowed to proceed for 2 hours at room temperature, after which the plates were washed 6 times with DuPont ELISA plate wash buffer (phosphate buffered saline (PBS), 0.05% Tween 20.) A second hybridization of reporter probe to the immobilized complex of capture probe and hybridized target RNA was carried out in the washed streptavidin coated well by addition of 120 μl of a hybridization cocktail containing 4 X SSC, 0.66% Triton X 100, 6.66% deionized formamide, 1 mg/mL BSA and 5 nM reporter probe. After hybridization for one hour at 37°C, the plate was again washed 6 times. Immobilized alkaline phosphatase activity was detected by addition of 100 μL of 0.2 mM 4-methylumbelliferyl phosphate (MUBP, JBL Scientific) in buffer δ (2.5 M diethanolamine pH 8.9 (JBL Scientific) , 10 mM MgCl 2 , 5 mM zinc acetate dihydrate and 5 mM iV-hydroxyethyl-ethylene-diamine-triacetic acid) . The plates were incubated at 37°C. Fluorescence at 450 nM was measured using a microplate fluorometer (Dynateck) exciting at 365 nM. Microplate based compound evaluation in HIV-1 infected MT-2 cells; Compounds to be evaluated were dissolved in DMSO and diluted in culture medium to twice the highest concentration to be tested and a maximum DMSO concentration of 2%. Further three-fold serial dilutions of the compound in culture medium were performed directly in U bottom microtiter plates (Nunc) . After compound dilution, MT-2 cells (50 μL) were added to a final concentration of 5 x 10^ per mL (1 x 10^ per well) . Cells were incubated with compounds for 30 minutes at 37°C in a CO 2 incubator. For evaluation of antiviral potency, an appropriate dilution of HIV-1 (RF) virus stock (50 μL) was added to culture wells containing cells and dilutions of the test compounds. The final volume in each well was 200 μL. Eight wells per plate were left uninfected with 50 μL of medium added in place of virus, while eight wells were infected in the absence of any antiviral compound. For evaluation of compound toxicity, parallel plates were cultured without virus infection. After 3 days of culture at 37°C in a humidified chamber inside a CO 2 incubator, all but 25 μL of medium/well was removed from the HIV infected plates . Thirty seven μL of 5 M GED containing biotinylated capture probe was added to the settled cells and remaining medium in each well to a final concentration of 3 M GED and 30 nM capture probe. Hybridization of the capture probe to HIV RNA in the cell lysate was carried out in the same microplate well used for virus culture by sealing the plate with a plate sealer (Costar) , and incubating for 16-20 hrs in a 37°C incubator. Distilled water was then added to each well to dilute the hybridization reaction three-fold and 150 μL of this diluted mixture was transferred to a streptavidin coated microtiter plate. HIV RNA was quantitated as described above. A standard curve, prepared by adding known amounts of pDAB 72 in vi tro RNA transcript to wells containing lysed uninfected cells, was run on each microtiter plate in order to determine the amount of viral RNA made during the infection. In order to standardize the virus inoculum used in the evaluation of compounds for antiviral activity, dilutions of virus were selected which resulted in an IC 90 value (concentration of compound required to reduce the HIV RNA level by 90%) for dideoxycytidine (ddC) of 0.2 μg/mL. IC 90 values of other antiviral compounds, both more and less potent than ddC, were reproducible using several stocks of HIV-1 (RF) when this procedure was followed. This concentration of virus corresponded to ~3 x 10^ PFU (measured by plaque assay on MT-2 cells) per assay well and typically produced approximately 75% of the maximum viral RNA level achievable at any virus inoculum. For the HIV RNA assay, IC 90 values were determined from the percent reduction of net signal (signal from infected cell samples minus signal from uninfected cell samples) in the RNA assay relative to the net signal from infected, untreated cells on the same culture plate (average of eight wells) . Valid performance of individual infection and RNA assay tests was judged according to three criteria. It was required that the virus infection should result in an RNA assay signal equal to or greater than the signal generated from 2 ng of pDAB 72 in vi tro RNA transcript. The IC 90 ror ddC, determined in each assay run, should be between 0.1 and 0.3 μg/mL. Finally, the plateau level of viral RNA produced by an effective reverse transcriptase inhibitor should be less than 10% of the level achieved in an uninhibited infection. A compound was considered active if its IC 90 was found to be less than 20μM. Compounds of the present invention have been found to have an IC 90 less than 20μM. For antiviral potency tests, all manipulations in microtiter plates, following the initial addition of 2X concentrated compound solution to a single row of wells, were performed using a Perkin El er/Cetus ProPette. HIV-1 RT Assay Materials and Methods This assay measures HIV-1 RT RNA dependent DNA polymerase activity by the incorporation of 3H dTMP onto the template primer Poly (rA) oligo (dT) 12-18. The template primer containing the incorporated radioactivity was separated from unincorporated label by one of two methods : Method 1. The template primer was precipitated with TCA, collected on glass fiber filters and counted for radioactivity with a scintillation counter. Method 2. The currently used method is more rapid and convenient. The template primer is captured on an diethyl amino ethyl (DEAE) ion exchange membrane which is then counted for radioactivity after washing off the free nucleotide. Materials and Reagents : The template primer Poly (rA) oligo (dT) 12-18 and dTTP were purchased from Pharmacia Biotech. The template primer and nucleotide were dissolved in diethyl pyrocarbonate water to a concentration of 1 mg/ml and 5.8 mM respectively. The substrates were aliquoted (template primer at 20 μl/aliquot, dTTP at 9 μl/aliquot) and frozen at -20 C. The 3H dTTP (2.5 mCi/ml in 10 mM Tricine at pH 7.6; specific activity of 90-120 Ci/mmol) and the recombinant HIV- 1 Reverse Transcriptase (HxB2 background; 100 U/10 μl in 100 mM potassium phosphate at pH 7.1, 1 mM dithiothreitol and 50% glycerol) were purchased from DuPont NEN. 1 Unit of enzyme is defined by DuPont NEN as the amount required to incorporate 1 nmol of labelled dTTP into acid-insoluble material in 10 minutes at 37 C. The 3H dTTP was aliquoted at 23.2 μl/microfuge tube (58 μCi) and frozen at -20 C. The HIV-1 Reverse Transcriptase (RT) was diluted 10 fold with RT buffer (80 mM KC1, 50 mM Tris HCl, 12 mM MgCl2 , 1 mM DTT, 50 μM EGTA, 5 mg/ml BSA, 0.01% Triton-X 100, pH 8.2) and aliquoted at 10 μl/microfuge tube (10 Units/10 μl) . One aliquot (enough for 8 assays) was diluted further to 10 Units/100 μl and aliquoted into 8 tubes (1.25 Units/12.5 μl) . All aliquots were frozen at -70 C. The Millipore Multiscreen DE 96 well filter plates, multiscreen plate adaptors, and microplate press-on adhesive sealing film were purchased from Millipore. The filter plate containing 0.65 μm pore size diethyl amino ethyl cellulose (DEAE) paper disks was pretreated with 0.3 M ammonium formate and 10 mM sodium pyrophosphate (2 times 200 μl /well) at pH 8.0 prior to use. A Skatron 96 well cell harvester and glass fiber filter mats were purchased from Skatron Instruments. Microscint 20 scintillation cocktail was purchased from Packard. Beckman Ready Flow III scintillation cocktail was purchased from Beckman. HIV-1 RT Assav: The enzyme and substrate mixture were freshly prepared from the above stock solutions. 1.25 Units of enzyme was diluted with RT buffer (containing 5 mg/ml BSA) to a concentration of 0.05 Units/10 μl or 0.7 nM. Final enzyme and BSA concentrations in the assay were 0.01 Units or 0.14 nM and 1 mg/ml respectively. The inhibitor and substrate mixture were diluted with RT buffer containing no BSA. All inhibitors were dissolved in dimethyl sulfoxide (DMSO) at a stock concentration of 3 mM and stored at -20 C after use. A Biomek robot was used to dilute the inhibitors in a 96 well plate. Inhibitors were initially diluted 96 fold from stock and then serially diluted two times (10 fold/dilution) from 31.25 μM to 3125 nM and 312.5 nM. Depending on the potency of the inhibitor, one of the three dilutions was further diluted. Typically the highest concentration (31.25 μM) was serially diluted three times at 5 fold/dilution to 6.25, 1.25, and 0.25 μM. Final inhibitor concentrations in the assay were 12.5, 2.5, 0.5, and 0.1 uM. For potent inhibitors of HIV-1 RT, the final inhibitor concentrations used were 0.1 or 0.01 that stated above. The substrate mixture contained 6.25 μg/ml of Poly (rA) oligo (dT) 12-18 and 12.5 μM of dTTP (58 μCi 3H dTTP) . The final substrate concentrations were 2.5 μg/ml and 5 μM respectively. Using the Beckman Instruments Biomek robot, 10 μl of HIV-1 RT was combined with 20 μl of inhibitor in a 96 well U bottom plate. The enzyme and inhibitor were preincubated at ambient temperature for 6 minutes. 20 μl of the substrate mixture was added to each well to initiate the reaction (total volume was 50 μl) . The reactions were incubated at 37 C and terminated after 45 minutes. For method 1, 200 μl of an ice-cold solution of 13% trichloroacetic acid (TCA) and 10 mM sodium pyrophosphate was added to each of the 96 wells. The 96 well plate was then placed in an ice-water bath for 30 minutes. Using A Skatron 96 well cell harvester, the acid precipitable material was collected on a glass fiber filter mat that had been presoaked in 13% TCA and 10 mM sodium pyrophosphate. The filter disks were washed 3 times (2.0 ml/wash) with 1 N HCl and 10 mM sodium pyrophosphate. The filter disks were punched out into scintillation vials, 2.0 ml of Beckman Ready Flow III scintillant was added, and the vials were counted for radioactivity for 1 minute. For method 2, the assay was terminated with the addition of 175 μl/well of 50 mM EDTA at pH 8.0. Then 180 μl of the mixture was transferred to a pretreated Millipore DE 96 well filter plate. Vacuum was applied to the filter plate to aspirate away the liquid and immobilize the template primer on the DEAE filter disks. Each well was washed 3 times with 200 μl of 0.3 M ammonium formate and 10 mM sodium pyrophosphate at pH 8.0. 50 μl of microscint 20 scintillation cocktail was added to each well and the plate was counted for radioactivity on a Packard Topcount at 1 minute/well . The IC 50 values are calculated with the equation: IC 50 = [Inh] / (1/fractional activity - 1) ,- where the fractional activity = RT activity (dpms) in the presence of inhibitor/RT activity (dpms) in the absence of inhibitor. For a given inhibitor, the IC 50 values were calculated for the inhibitor concentrations that range between 0.1-0.8 fractional activity. The IC 50 values in this range (generally 2 values) were averaged. A compound was considered active if its IC 50 was found to be less than 60uM. Compounds of the present invention have been found to have an IC 50 less than 60μM. Protein Binding and Mutant Resistance In order to characterize NNRTI analogs for their clinical efficacy potential the effect of plasma proteins on antiviral potency and measurements of antiviral potency against wild type and mutant variants of HIV which carry amino acid changes in the known binding site for NNRTIs were examined. The rationale for this testing strategy is two fold: 1. Many drugs are extensively bound to plasma proteins. Although the binding affinity for most drugs for the major components of human plasma, namely, human serum albumin (HSA) or alpha-1-acid glycoprotein (AAG) , is low, these major components are present in high concentration in the blood. Only free or unbound drug is available to cross the infected cell membrane for interaction with the target site (i.e., HIV-1 reverse transcriptase, HIV-1 RT) . Therefore, the effect of added HSA+AAG on the antiviral potency in tissue culture more closely reflects the potency of a given compound in the clinical setting. The concentration of compound required for 90% inhibition of virus replication as measured in a sensitive viral RNA-based detection method is designated the IC90. The fold increase in apparent IC90 for test compounds in the presence or added levels of HSA and AAG that reflect in vivo concentrations (45 mg/ml HSA, 1 mg/ml AAG) was then calculated. The lower the fold increase, the more compound will be available to interact with the target site. 2. The combination of the high rate of virus replication in the infected individual and the poor fidelity of the viral RT results in the production of a quasi-species or mixtures of HIV species in the infected individual. These species will include a majority wild type species, but also mutant variants of HIV and the proportion of a given mutant ■ will reflect its relative fitness and replication rate. Because mutant variants including mutants with changes in the amino acid sequence of the viral RT likely pre-exist in the infected individual's quasi-species, the overall potency observed in the clinical setting will reflect the ability of a drug to inhibit not only wild type HIV-1, but mutant variants as well. We thus have constructed, in a known genetic background, mutant variants of HIV-1 which carry amino acid substitutions at positions thought to be involved in NNRTI binding, and measured the ability of test compounds to inhibit replication of these mutant viruses. The concentration of compound required for 90% inhibition of virus replication as measured in a sensitive viral RNA-based detection method is designated the IC90. It is desirable to have a compound which has high activity against a variety of mutants. Dosage and Formulation The antiviral compounds of this invention can be administered as treatment for viral infections by any means that produces contact of the active agent with the agent's site of action, i.e., the viral reverse transcriptase, in the body of a mammal. They can be administered by any conventional means available for use in conjunction with pharmaceuticals, either as individual therapeutic agents or in a combination of therapeutic agents . They can be administered alone, but preferably are administered with a pharmaceutical carrier selected on the basis of the chosen route of administration and standard pharmaceutical practice. The dosage administered will, of course, vary depending upon known factors, such as the pharmacodynamic characteristics of the particular agent and its mode and route of administration; the age, health and weight of the recipient; the nature and extent of the symptoms; the kind of concurrent treatment; the frequency of treatment; and the effect desired. A daily dosage of active ingredient can be expected to be about 0.001 to about 1000 milligrams per kilogram of body weight, with the preferred dose being about 0.1 to about 30 mg/kg. Dosage forms of compositions suitable for administration contain from about 1 mg to about 100 mg of active ingredient per unit. In these pharmaceutical compositions the active ingredient will ordinarily be present in an amount of about 0.5-95% by weight based on the total weight of the composition. The active ingredient can be administered orally in solid dosage forms, such as capsules, tablets and powders, or in liquid dosage forms, such as elixirs, syrups and suspensions. It can also be administered parenterally, in sterile liquid dosage forms. Gelatin capsules contain the active ingredient and powdered carriers, such as lactose, starch, cellulose derivatives, magnesium stearate, stearic acid, and the like. Similar diluents can be used to make compressed tablets. Both tablets and capsules can be manufactured as sustained release products to provide for continuous release of medication over a period of hours . Compressed tablets can be sugar coated or film coated to mask any unpleasant taste and protect the tablet from the atmosphere, or enteric coated for selective disintegration in the gastrointestinal tract. Liquid dosage forms for oral administration can contain coloring and flavoring to increase patient acceptance. In general, water, a suitable oil, saline, aqueous dextrose (glucose) , and related sugar solutions and glycols such as propylene glycol or polyethylene glycols are suitable carriers for parenteral solutions . Solutions for parenteral administration preferably contain a water soluble salt of the active ingredient, suitable stabilizing agents, and if necessary, buffer substances. Antioxidizing agents such as sodium bisulfite, sodium sulfite, or ascorbic acid, either alone or combined, are suitable stabilizing agents. Also used are citric acid and its salts, and sodium EDTA. In addition, parenteral solutions can contain preservatives, such as benzalkonium chloride, methyl- or propyl-paraben and chlorobutanol . Suitable pharmaceutical carriers are described in Remington 's Pharmaceutical Sciences, supra, a standard reference text in this field. Useful pharmaceutical dosage-forms for administration of the compounds of this invention can be illustrated as follows : Capsules A large number of unit capsules can be prepared by filling standard two-piece hard gelatin capsules each with 100 mg of powdered active ingredient, 150 mg of lactose, 50 mg of cellulose, and 6 mg magnesium stearic. Soft Gelatin Capsules A mixture of active ingredient in a digestible oil such as soybean oil, cottonseed oil or olive oil can be prepared and injected by means of a positive displacement pump into gelatin to form soft gelatin capsules containing 100 mg of the active ingredient . The capsules should then be washed and dried. Tablets A large number of tablets can be prepared by conventional procedures so that the dosage unit is 100 mg of active ingredient, 0.2 mg of colloidal silicon dioxide, 5 milligrams of magnesium stearate, 275 mg of microcrystalline cellulose, 11 mg of starch and 98.8 mg of lactose. Appropriate coatings may be applied to increase palatability or delay absorption. Suspension An aqueous suspension can be prepared for oral administration so that each 5 mL contain 25 mg of finely divided active ingredient, 200 mg of sodium carboxymethyl cellulose, 5 mg of sodium benzoate, 1.0 g of sorbitol solution, U.S. P., and 0.025 mg of vanillin. Injectable A parenteral composition suitable for administration by injection can be prepared by stirring 1.5% by weight of active ingredient in 10% by volume propylene glycol and water. The solution is sterilized by commonly used techniques . Combination of components (a) and (b) Each therapeutic agent component of this invention can independently be in any dosage form, such as those described above, and can also be administered in various ways, as described above. In the following description component (b) is to be understood to represent one or more agents as described previously. Thus, if components (a) and (b) are to be treated the same or independently, each agent of component (b) may also be treated the same or independently. Components (a) and (b) of the present invention may be formulated together, in a single dosage unit (that is, combined together in one capsule, tablet, powder, or liquid, etc.) as a combination product. When component (a) and (b) are not formulated together in a single dosage unit, the component (a) may be administered at the same time as component (b) or in any order; for example component (a) of this invention may be administered first, followed by administration of component (b) , or they may be administered in the revserse order. If component (b) contains more that one agent, e.g., one RT inhibitor and one protease inhibitor, these agents may be administered together or in any order. When not administered at the same time, preferably the administration of component (a) and (b) occurs less than about one hour apart . Preferably, the route of administration of component (a) and (b) is oral. The terms oral agent, oral inhibitor, oral compound, or the like, as used herein, denote compounds which may be orally administered. Although it is preferable that component (a) and component (b) both be administered by the same route (that is, for example, both orally) or dosage form, if desired, they may each be administered by different routes (that is, for example, one component of the combination product may be administered orally, and another component may be administered intravenously) or dosage forms. As is appreciated by a medical practitioner skilled in the art, the dosage of the combination therapy of the invention may vary depending upon various factors such as the pharmacodynamic characteristics of the particular agent and its mode and route of administration, the age, health and weight of the recipient, the nature and extent of the symptoms, the kind of concurrent treatment, the frequency of treatment, and the effect desired, as described above. The proper dosage of components (a) and (b) of the present invention will be readily ascertainable by a medical practitioner skilled in the art, based upon the present disclosure. By way of general guidance, typically a daily dosage may be about 100 milligrams to about 1.5 grams of each component. If component (b) represents more than one compound, then typically a daily dosage may be about 100 milligrams to about 1.5 grams of each agent of component (b) . By way of general guidance, when the compounds of component (a) and component (b) are administered in combination, the dosage amount of each component may be reduced by about 70- 80% relative to the usual dosage of the component when it is administered alone as a single agent for the treatment of HIV infection, in view of the synergistic effect of the combination. The combination products of this invention may be formulated such that, although the active ingredients are combined in a single dosage unit, the physical contact between the active ingredients is minimized. In order to minimize contact, for example, where the product is orally administered, one active ingredient may be enteric coated. By enteric coating one of the active ingredients, it is possible not only to minimize the contact between the combined active ingredients, but also, it is possible to control the release of one of these components in the gastrointestinal tract such that one of these components is not released in the stomach but rather is released in the intestines. Another embodiment of this invention where oral administration is desired provides for a combination product wherein one of the active ingredients is coated with a sustained-release material which effects a sustained-release throughout the gastrointestinal tract and also serves to minimize physical contact between the combined active ingredients. Furthermore, the sustained-released component can be additionally enteric coated such that the release of this component occurs only in the intestine. Still another approach would involve the formulation of a combination product in which the one component is coated with a sustained and/or enteric release polymer, and the other component is also coated with a polymer such as a lowviscosity grade of hydroxypropyl methylcellulose or other appropriate materials as known in the art, in order to further separate the active components. The polymer coating serves to form an additional barrier to interaction with the other component. In each formulation wherein contact is prevented between components (a) and (b) via a coating or some other material, contact may also be prevented between the individual agents of component (b). Dosage forms of the combination products of the present invention wherein one active ingredient is enteric coated can be in the form of tablets such that the enteric coated component and the other active ingredient are blended together and then compressed into a tablet or such that the enteric coated component is compressed into one tablet layer and the other active ingredient is compressed into an additional layer. Optionally, in order to further separate the two layers, one or more placebo layers may be present such that the placebo layer is between the layers of active ingredients. In addition, dosage forms of the present invention can be in the form of capsules wherein one active ingredient is compressed into a tablet or in the form of a plurality of microtablets, particles, granules or non-perils, which are then enteric coated. These enteric coated microtablets, particles, granules or non-perils are then placed into a capsule or compressed into a capsule along with a granulation of the other active ingredient. These as well as other ways of minimizing contact between the components of combination products of the present invention, whether administered in a single dosage form or administered in separate forms but at the same time or concurrently by the same manner, will be readily apparent to those skilled in the art, based on the present disclosure. Pharmaceutical kits useful for the treatment of HIV infection, which comprise a therapeutically effective amount of a pharmaceutical composition comprising a compound of component (a) and one or more compounds of component (b) , in one or more sterile containers, are also within the ambit of the present invention. Sterilization of the container may be carried out using conventional sterilization methodology well known to those skilled in the art. Component (a) and component (b) may be in the same sterile container or in separate sterile containers. The sterile containers of materials may comprise separate containers, or one or more multi-part containers, as desired. Component (a) and component (b) , may be separate, or physically combined into a single dosage form or unit as described above. Such kits may further include, if desired, one or more of various conventional pharmaceutical kit components, such as for example, one or more pharmaceutically acceptable carriers, additional vials for mixing the components, etc., as will be readily apparent to those skilled in the art. Instructions, either as inserts or as labels, indicating quantities of the components to be administered, guidelines for administration, and/or guidelines for mixing the components, may also be included in the kit. Obviously, numerous modifications and variations of the present invention are possible in light of the above teachings. It is therefore to be understood that within the scope of the appended claims, the invention may be practiced otherwise than as specifically described herein.

Claims: WHAT IS CLAIMED AS NEW AND DESIRED TO BE SECURED BY LETTER PATENT OF UNITED STATES IS; 1. A compound of Formula (I) : (I) or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein: A is O or S; W is N or CR 3 ; X is N or CR 4 ; Y is N or CR 5 ; Z is N or CR 6 ; C f is cyclopropyl or Cι_ 3 alkyl substituted with 3-7 halogen; provided that the number of W, X, Y, and Z which are N, is zero, one or two; R l is selected from: -C0 2 R 12 , -COR 12 , -S0 2 R 12 , -SOR 12 , -CONHR l2 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , -Cι_ 6 alkyl substituted with 0-3 R 11 , -(CH 2 ) p phenyl substituted with 0-3 R i0 , and -(CH 2 ) P (C 3 _ 5 cycloalkyl); R 2 is selected from: -CH=CR 7 R 8 , -C≡C-R 8 , -CH=CHCHR 7 R 8 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C=C-R 8 , -Cι-4 alkyl substituted with 0-3 R 11 , - (CH2) p phenyl substituted with 0-3 R 10 , and -(CH 2 ) P (C3_5 cycloalkyl); R 3 is selected from: H, F, Cl, Br, I, -OH, 0CF , -CN, N0 2 , CHO, C(=0)CH 3 , C(=0)CF , C(=0)NH 2 , C(=0)NHCH 3 , NR 7 R 7a , NR 7 C(=0)OR 7b , C(=0)0R 7 , SR 7 , S(=0)R 7 , S0 2 R 7 , S0 2 NHR 7 , NR 7 S0 2 R 7b , C 1 - 3 alkyl substituted with 0-3 R 11 , C 2 - 3 alkenyl, C 2 - 3 alkynyl, C 1 -. 3 alkoxy, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S and substituted with 0-2 R 10 ; R 4 is selected from: H, F, Cl, Br, I, -OH, OCF 3 , -CN, N0 2 , CHO, C(=0)CH 3 , C(=0)CF 3 , C(=0)NH 2 , C(=0)NHCH 3 , NR 7 R 7 , NR 7 C(=0)OR 7b , C(=0)0R 7 , SR 7 , S(=0)R 7 , S0 2 R 7 , S0 2 NHR 7 , NR 7 S0 2 R 7b , C 1 - 3 alkyl substituted with 0-3 R 11 , C 2 - 3 alkenyl, C 2 - 3 alkynyl, Cι_ 3 alkoxy, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R 10 ; alternatively, R 3 and R 4 , when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form a 5-7 membered carbocyclic ring, said carbocyclic ring being aromatic or nonaromatic, said carbocyclic ring being substituted with 0-2 R l °; alternatively, R 3 and R 4 , when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form a 5-7 membered heterocyclic ring containing 1, 2 or 3 heteroatoms atoms selected from the group consisting of N, O, and S, said heterocyclic ring being aromatic or nonaromatic, said heterocyclic ring being substituted with 0-2 R 10 ; R 5 is selected from H, F, Cl, Br, I, -OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy; alternatively, R 4 and R 5 , when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form a 5-7 membered carbocyclic ring, said carbocyclic ring being aromatic or nonaromatic, said carbocyclic ring being substituted with 0-2 R l °; alternatively, R 4 and R 5 , when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form a 5-7 membered heterocyclic ring containing 1, 2 or 3 heteroatoms atoms selected from the group consisting of N, 0, and S, said heterocyclic ring being aromatic or nonaromatic, said heterocyclic ring being substituted with 0-2 R 10 ,- R 6 is selected from: H, OH, F, Cl, Br, I, OCF 3 , -CN, N0 2 , CHO, C(=0)CH 3 , C(=0)CF 3 , C(=0)NH 2 , C(=0)NHCH 3 , NR 7 R 7a , NR 7 C(=0)OR 7b , C(=0)OR 7 , SR 7 , S(=0)R 7 , S0 2 R 7 , S0 2 NHR 7 , NR 7 S0 2 R 7b , C 1 - 3 alkyl substituted with 0-3 R 11 , C 2 - 3 alkenyl, C 2 - 3 alkynyl, C 1 - 3 alkoxy, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R i0 ; R 7 , at each occurrence, is selected from H, methyl, ethyl, propyl, and butyl; R 7a , at each occurrence, is selected from H, methyl, ethyl, propyl , and butyl ; ; R 7b , at each occurrence, is methyl, ethyl, propyl, or butyl; R 8 , at each occurrence, is selected from: H, F, Cl, Br, I, CH (-OCH 2 CH 2 0-) , Cι_ 4 haloalkyl, Ci- 6 alkyl substituted with 0-3 R 11 , C 2 - 6 alkenyl, C 3 - 7 cycloalkyl substituted with 0-2 R 9 , phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S and substituted with 0-2 R l °; R 9 , at each occurrence, is selected from D, OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, and F; R l °, at each occurrence, is selected from OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, F, Cl, Br, I, CN, NR 7 R 7a , and C(=0)CH 3 ; R U , at each occurrence, is selected from OR 7 , CN, F, Cl, Br, I, N0 , NR 7 R 7a , CHO, C(=0)CH , C(=0)NH 2 ; R i2 , at each occurrence, is selected from Ci- 6 alkyl, C 2 - 4 alkenyl, C 2 - 4 alkynyl, C 3 _ 7 cycloalkyl, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-3 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R i0 , -(CH 2 ) p phenyl substituted with 0-2 R 10 , and - (CH 2 ) P (C 3 _ 5 cycloalkyl); and p, at each occurrence, is selected from 0, 1, 2, and 3; provided, if, simultaneously, each of W, X, Y, and Z are carbon, then R is not unsubstituted C 1 - 4 alkyl. 2. A compound according to Claim 1 of Formula (II): ( ID wherein: A is 0 or S; C f is -CF 3 , -CF 2 CF 3 , or -CF 2 CF 2 CF 3 ; R l is selected from: -C0 2 R 12 , -COR 22 , -S0 2 R 12 , -S0R12, -CONHR 12 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , -Cι_ 6 alkyl substituted with 0-3 R 11 , - (CH 2 ) p phenyl substituted with 0-3 R 10 , and -(CH 2 )p(C 3 -5 cycloalkyl); R 2 is selected from: -CH=CR 7 R 8 , -C≡C-R 8 , -CH=CHCHR 7 R 8 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , -(CH 2 ) p phenyl substituted with 0-3 R 10 , and -(CH 2 ) p (C 3 - 5 cycloalkyl) ,- R 3 is selected from: H, F, Cl, Br, I, -OH, OCF , -CN, N0 2 , CHO, C(=0)CH 3 , C(=0)CF 3 , C(=0)NH 2 , C(=0)NHCH 3 , NR 7 R 7a , NR 7 C(=0)OR 7b , C(=0)OR 7 , SR 7 , S(=0)R 7 , S0 2 R 7 , S0 2 NHR 7 , NR 7 S0 2 R 7b , Cι_ 3 alkyl substituted with 0-3 R 11 , C 2 - 3 alkenyl, C 2 - 3 alkynyl, C 1 -. 3 alkoxy, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R 10 ; R 4 is selected from: H, F, Cl, Br, I, -OH, OCF , -CN, N0 2 , CHO, C(=0)CH 3 , C(=0)CF 3 , C(=0)NH 2 , C(=0)NHCH 3 , NR 7 R 7a , NR 7 C(=0)OR 7b , C(=0)OR 7 , SR 7 , S(=0)R 7 , S0 2 R 7 , S0 2 NHR 7 , NR 7 S0 2 R 7b , Cι_ 3 alkyl substituted with 0-3 R 11 , C 2 - 3 alkenyl, C 2 - 3 alkynyl, C 1 - 3 alkoxy, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R 10 ; alternatively, R 3 and R 4 , when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form -0-CH 2 -0-, -0-CH 2 -CH 2 -0-, or -CH=CH-CH=CH- ; R 5 is selected from H, F, Cl, Br, I, -OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy; alternatively, R 4 and R 5 , when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form -0-CH 2 -0-, -0-CH -CH -0-, or -CH=CH-CH=CH- ; R 6 is selected from: H, OH, F, Cl, Br, I, 0CF 3 , -CN, N0 2 , CHO, C(=0)CH 3 , C(=0)CF 3 , C(=0)NH 2 , C(=0)NHCH 3 , NR 7 R 7a , NR 7 C(=0)0R 7b , C(=0)OR 7 , SR 7 , S(=0)R 7 , S0 2 R 7 , S0 2 NHR 7 , NR 7 Sθ2R 7b , Cχ_ 3 alkyl substituted with 0-3 R 11 , C 2 - 3 alkenyl, C 2 - 3 alkynyl, C 1 - 3 alkoxy, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R 10 ; R 7 , at each occurrence, is selected from H, methyl, ethyl, propyl, and butyl; R 7 , at each occurrence, is selected from H, methyl, ethyl, propyl , and butyl; ; R 7b , at each occurrence, is methyl, ethyl, propyl, or butyl; R 8 , at each occurrence, is selected from: H, F, Cl, Br, I, CH(-OCH 2 CH 2 0-) , Ci- 4 haloalkyl, Ci- 6 alkyl substituted with 0-3 R 11 , C 2 - 6 alkenyl, C 3 - 7 cycloalkyl substituted with 0-2 R 9 , phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-4 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R i0 ; R 9 , at each occurrence, is selected from D, OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, and F; R 10 , at each occurrence, is selected from OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, F, Cl, Br, I, CN, NR 7 R 7a , and C(=0)CH 3 ; R U , at each occurrence, is selected from OR 7 , CN, F, Cl, Br, I, N0 2 , NR 7 R 7a , CHO, C(=0)CH 3 , C(=0)NH 2 ; R 2 , at each occurrence, is selected from Cι_ 6 alkyl, C 2 - 4 alkenyl, C 2 - 4 alkynyl, C 3 - 7 cycloalkyl, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-3 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R i0 , -(CH 2 ) p phenyl substituted with 0-2 R 10 , and -(CH 2 ) p (C 3 - 5 cycloalkyl); and p, at each occurrence, is selected from 0, 1, 2, and 3. 3. A compound according to Claim 2, wherein: A is O or S ; C f is -CF 3 , -CF 2 CF 3 , or -CF 2 CF 2 CF 3 ; R l is selected from: -C0 2 R l2 , -COR 12 , -S0 2 R l2 , -SOR 12 , -CONHR 12 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , -Cι_ 5 alkyl substituted with 0-3 R 11 , -(CH 2 ) p phenyl substituted with 0-3 R l °, and -(CH 2 ) p (C 3 -5 cycloalkyl); R 2 is selected from: -CH=CR 7 R 8 , -C≡C-R 8 , -CH=CHCHR 7 R 8 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , - (CH 2 ) p phenyl substituted with 0-3 R l °, and -(CH 2 ) p (C 3 - 5 cycloalkyl); R 3 is selected from: H, F, Cl, Br, I, -OH, -OCF 3 , -CN, -N0 2 , -CHO, -C(=0)CH 3 , -C(=0)CF 3 , -C(=0)NH 2 , -C(=0)NHCH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHC(=0)OCH 3 , -C(=0)OCH 3 , -SCH 3 , -S(=0)CH 3 , -SO 2 CH 3 , -SO 2 NHCH 3 , -NHSO 2 CH 3 , C 1 - 3 alkyl substituted with 0-3 R 11 , C 2 - 3 alkenyl, C 2 - 3 alkynyl, Cι_ 3 alkoxy, R 4 is selected from: H, F, Cl, Br, I, -OH, OH, -OCF 3 , -CN, -N0 2 , -CHO, -C(=0)CH 3 , -C(=0)CF 3 , -C(=0)NH 2 , -C(=0)NHCH 3 , -NH 2 , -NHCH3, -NHCH 2 CH 3 , -N(CH 3 ) 2 , -N(CH 2 CH 3 ) 2 , -NHC(=0)OCH 3 , -NHC(=0)OCH 2 CH 3 , -C(=0)OCH 3 , -C(=0)OCHCH 3 , -SCH 3 , -SCH 2 CH 3 , -S(=0)CH 3 , -S(=0)CH 2 CH 3 , -S0 2 H, -SO 2 CH 3 , -S0 2 CH 2 CH 3 , -SO 2 NHCH 3 , -SO 2 NHCH 2 CH 3 , -NHSO 2 CH 3 , -NHSO 2 CH 2 CH 3 , C 1 - 3 alkyl substituted with 0-3 R 11 , C 2 - 3 alkenyl, C 2 - 3 alkynyl, C 1 - 3 alkoxy, alternatively, R 3 and R 4 , when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form -O-CH 2 -O-, -O-CH 2 -CH 2 -O-, or -CH=CH-CH=CH- ; R 5 is selected from H, F, Cl, Br, I, -OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, and butoxy; alternatively, R 4 and R 5 , when substituents on adjacent carbon atoms, are taken together with the carbon atoms to which they are attached to form -O-CH 2 -O-, -O-CH 2 -CH 2 -O-, or -CH=CH-CH=CH- ; R 6 is selected from: H, F, Cl, Br, I, -OH, -OCF 3 , -CN, -N0 2 , -CHO, -C(=0)CH 3 , -C(=0)CF 3 , -C(=0)NH 2 , -C(=0)NHCH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHC(=0)0CH 3 , -C(=0)OCH 3 , -SCH 3 , -S(=0)CH 3 , -SO 2 CH 3 , -SO 2 NHCH 3 , -NHSO 2 CH 3 , C 1 - 3 alkyl substituted with 0-3 R 11 , C2- 3 alkenyl, C 2 - 3 alkynyl, C 1 - 3 alkoxy, R 7 , at each occurrence, is selected from H, methyl, ethyl, propyl, and butyl; R 7a , at each occurrence, is selected from H, methyl, ethyl, propyl , and butyl ; ; R 8 , at each occurrence, is selected from: H, F, Cl, Br, I, CH ( -OCH 2 CH 2 0- ) , Ci- 4 haloalkyl, Ci- 6 alkyl substituted with 0-3 R 11 , C 2 - 6 alkenyl, C 3 _ 7 cycloalkyl substituted with 0-2 R 9 , phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-3 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R 10 ; R 9 , at each occurrence, is selected from D, OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, and F; R 10 , at each occurrence, is selected from OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, F, Cl, Br, I, CN, NR 7 R 7a , and C(=0)CH 3 ; RH, at each occurrence, is selected from OR 7 , CN, F, Cl, Br, I, N0 2 , NR 7 R 7a , CHO, C(=0)CH 3 , C(=0)NH 2 ; R i2 , at each occurrence, is selected from Cι_ 6 alkyl, C 2 - 4 alkenyl, C2-4 alkynyl, C 3 -. 7 cycloalkyl, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-3 heteroatoms selected from the group consisting of N, 0, and S and substituted with 0-2 R 10 , -(CH ) p phenyl substituted with 0-2 R 10 , and -(CH 2 ) P (C 3 _ 5 cycloalkyl); and p, at each occurrence, is selected from 0, 1, 2, and 3. 4. A compound according to Claim 3, wherein: A is 0; C f is -CF 3 or -CF CF 3 ; R l is selected from: -C0 2 R 12 , -COR 12 , -S0 2 R 12 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , -Cι_ 5 alkyl substituted with 0-3 R 11 , - (CH 2 ) p phenyl substituted with 0-3 R 10 , and -(CH 2 ) P (C 3 _ 5 cycloalkyl) ; R is selected from: -CH=CR 7 R 8 , -C≡C-R 8 , -CH=CHCHR 7 R 8 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , -(CH 2 ) p phenyl substituted with 0-3 R 10 , and -(CH ) p (C 3 _ 5 cycloalkyl); R 3 is selected from: H, F, Cl, Br, I, -OH, -OCF 3 , -CN, -N0 2 , -CHO, -C(=0)CH 3 , -C(=0)CF 3 , -NH 2 , -NHCH3, -N(CH 3 ) 2 , -CF 3 , -CH 3 , -CH 2 CH 3 , -OCH 3 , and -0CH 2 CH 3 , R 4 is selected from: H, F, Cl, Br, I, -OH, OH, -OCF 3 , -CN, -N0 2 , -CHO, -C(=0)CH 3 , -C(=0)CF 3 , -C(=0)NH 2 , -C(=0)NHCH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHC(=0)OCH , -C(=0)OCH 3 , -CF 3 , -CH 3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 ; R 5 is selected from H, F, Cl, Br, I, -OH, -CH 3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 ; R 6 is selected from: H, F, Cl, Br, I, -OH, -OCF 3 , -CN, -N0 2 , -CHO, -C(=0)CH 3 , -C(=0)CF 3 , -NH , -NHCH3, -N(CH 3 ) 2 , -CF3 , -CH3 , -CH2CH3, -OCH3, and -OCH2CH3; R 7 , at each occurrence, is selected from H, methyl, ethyl, propyl, and butyl; R 8 , at each occurrence, is selected from: H, F, Cl, Br, I, CH ( -OCH 2 CH 2 0- ) , C 1 - 4 haloalkyl, C 1 - 4 alkyl substituted with 0-3 R 11 , C 2 - 4 alkenyl, C 3 - 6 cycloalkyl substituted with 0-2 R 9 , phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-3 heteroatoms selected from the group consisting of pyridinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, and oxazolidinyl; R 9 , at each occurrence, is selected from D, OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, and F; R l °, at each occurrence, is selected from OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, F, Cl, Br, I, CN, -NH 2 , -NHCH3 , -NHCH 2 CH 3 , -N(CH 3 ) 2 , -N(CH 2 CH 3 ) 2 , and C(=0)CH 3 ; R U , at each occurrence, is selected from OR 7 , CN, F, Cl, Br, I, N0 2 , -NH 2 , -NHCH3, -NHCH2CH3, -N(CH 3 ) 2 , -N(CH 2 CH 3 ) 2 , CHO, C(=0)CH 3/ C(=0)NH 2 ; R l2 , at each occurrence, is selected from Cι_ 6 alkyl, C 2 - 4 alkenyl, C 2 - 4 alkynyl, C 3 - 6 cycloalkyl, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-3 heteroatoms selected from the group consisting pyridinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, and oxazolidinyl, - (CH 2 ) p phenyl substituted with 0-2 R 10 , and -(CH ) p (C 3 - 5 cycloalkyl); and p, at each occurrence, is selected from 0, 1, and 2. 5. A compound according to Claim 4 of Formula (III) (III) wherein: R l is selected from: -CF 3 , -CF 2 H, -CH 3 , -CH 2 CH 3 , -CH 2 CH 2 CH 3 , -CH 2 CH 2 CH 2 CH 3 , -CH(CH 3 ) 2 , -CH 2 CH(CH 3 ) 2 , -CH 2 CH 2 C (CH 3 ) 3 , -CH 2 CH 2 CH(CH 3 )CH 3 , -CH(=CH 2 )CH 3 , -CH 2 CH=CH 2 , -CH 2 -CH=C (CH 3 ) 2 , -CH 2 -C≡CH, -CH 2 -C≡CCH 3 , -CH 2 Ph, -cycPr, -CH 2 cycPr, -CH 2 CH 2 cycPr, -CO 2 CH 3 , -C0 2 CH 2 CH 3 , -CO 2 CH 2 CH 2 CH 3 , -CO 2 CH 2 CH 2 CH 2 CH 3 , -C0 2 CH(CH 3 ) 2 , -C0 2 CH 2 CH(CH3)2, -C0 2 CH 2 Ph, -C0 2 cycPr, -C0 2 CH 2 cycPr, -C0 2 CH 2 CH=CH 2 , -S0 2 CH 2 CH 3/ -S0 2 CH(CH 3 ) 2 , -COCH 3 , -COCH 2 CH 3 , -C0CH 2 CH 2 CH 3 , -COCH(CH 3 ) 2 , and -COCH 2 cycPr; R 2 is selected from: benzyl, phenethyl, -CH 2 CH 2 cycPr, -C≡C-CH 3 , -C≡C-CF 3 , -C≡C-Et, -C≡C-iPr, -C≡C-cycPr, -C≡C-1- (CH 3 )cycPr, -C≡C-CH=CH 2 , -C≡C-C (=CH 2 ) CH 3 , -CH=CH-CH 3 , -CH=CH-CF 3 , -CH=CH-Et, -CH=CH-iPr, -CH=CH-cycPr, -CH=CH-CH=CH 2 , -CH 2 -C=C-CH 3 , -CH 2 -C≡C-CF 3 , -CH 2 -C≡C-Et, -CH -C≡C-iPr , -CH 2 -C≡C-cycPr, -CH 2 -C≡C-CH=CH 2 , -CH 2 -CH=CH 2 , -CH -CH=CH-CH 3 , -CH -CH=CH-CF 3 , -CH 2 -CH=CH-Et , -CH 2 -CH=CH-iPr, -CH 2 -CH=CH-cycPr , -CH 2 -CH=CH-CH=CH 2 , -CH 2 -CH=C(CH 3 ) 2 , and -CH=CH-CH 2 -cycPr; R 3 is selected from: H, F, Cl, Br, I, -OH, -OCF 3 , -CN, -N0 , -C(=0)CH 3 , -C(=0)CF 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -CF 3 , -CH 3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 , R 4 is selected from: H, F, Cl, Br, I, -OH, OH, -OCF 3 , -CN, -N0 2 , -C(=0)CH 3 , -C(=0)CF 3 , -C(=0)NH 2 , -C(=0)NHCH , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHC(=0)OCH 3 , -C(=0)OCH 3 , -CF 3 , -CH 3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 ; R 5 is selected from H, F, and Cl; and R 6 is selected from: H, F, Cl -OH, -OCF 3 , -CF 3 , -CH 3 , and -OCH 3 . 6. A compound according to Claim 2, wherein the compound is selected from: 4- (cyclopropylmethyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one; 4- (methyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4- dihydro-quinoxalin-2 (IH) -one; 3- (n-butyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) - one; 4- (methyl) -3- (n-butyl) -3- (trifluoromethyl) -3 , 4-dihydro- quinoxalin-2 (IH) -one; 3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro- quinoxalin-2 (IH) -one; 3- (allyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) - one; 4- (allyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4- dihydro-quinoxalin-2 (IH) -one; 4- (benzyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4- dihydro-quinoxalin-2 (IH) -one; 4- (cyclopropylmethyl) -3- (allyl) -3- (trifluoromethyl) -3,4- dihydro-quinoxalin-2 (IH) -one; 4- (propargyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) - 3 , 4-dihydro-quinoxalin-2 (IH) -one; 4- (cyclopropylethyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one; 4- (isopropyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) - 3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (fluoro) -4- (allyl) -3- (n-butyl) -3- (trifluoromethyl) -3 , 4- dihydro-quinoxalin-2 (IH) -one; 6- (fluoro) -4- (allyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one; 6- (fluoro) -4- (cyclopropylmethyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (fluoro) -4- (cyclopropylmethyl) -3- (n-butyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one; 6- (chloro) -4- (cyclopropylmethyl) -3- (2-cyclopropylethynyl) -3- ( trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (chloro) -4- (isobutyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (chloro) -4- (allyl) -3- (2-cyclopropylethynyl) -3- ( trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (chloro) -4- (cyclopropylmethyl) -3- (phenethyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (chloro) -4- (allyl) -3- (phenethyl) -3- (trifluoromethyl) -3,4- dihydro-quinoxalin-2 (IH) -one,- 6- (methoxy) -4- (cyclopropylmethyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one; 6- (methoxy) -4- (allyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 4- (cyclopropylmethyl) -3- (1-propynyl) -3- (trifluoromethyl) -3 , 4- dihydro-quinoxalin-2 (IH) -one; 4- (allyl) -3- (1-propynyl) -3- (trifluoromethyl) -3 , 4-dihydro- quinoxalin-2 (IH) -one; 4- (ethoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one; 4- (ethoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 4- (isopropoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 4- (propen-2-yl-oxycarbonyl) -3- (2-cyclopropylethynyl) -3- ( trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (isobutoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3, 4-dihydro-quinoxalin-2 (IH) -one; - (n-butoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (allyloxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (benzyloxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (n-propylsulfonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (phenylcarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (neopentyl-oxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (2-propynyl-oxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (isopropylcarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (cyclopropylcarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (ethylsulfonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; - (isopropylsulfonyl) -3- (2-cyclopropylethynyl) -3- ( rifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 4- (methoxycarbonyl) -3- (2-cyclopropylethynyl) -3- ( trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (chloro) -4- (ethoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (chloro) -4- (isopropoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (chloro) -4- (propen-2-yl-oxycarbonyl) -3- (2- cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro- quinoxalin-2 (IH) -one; 6- (fluoro) -4- (ethoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; 6- (fluoro) -4- (isopropoxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one; and 6- (fluoro) -4- (propen-2-yl-oxycarbonyl) -3- (2-cyclopropylethynyl) -3- (trifluoromethyl) -3 , 4-dihydro-quinoxalin-2 (IH) -one. 7. A compound according to Claim 1 of Formula (lib), (lib) wherein : A is O or S; W is N or CR 3 ; X is N or CR 4 ; Y is N or CR 5 ; Z is N or CR 6 ; C f is -CF 3 , -CF 2 CF 3 , or -CF 2 CF 2 CF 3 ; provided that one or two of W, X, Y, and Z are N; R l is selected from: -C0 2 R 12 , -COR 12 , -S0 2 R 12 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , -Cι_ 5 alkyl substituted with 0-3 R 11 , - (CH 2 ) p phenyl substituted with 0-3 R 10 , and -(CH 2 ) p (C 3 -5 cycloalkyl); R 2 is selected from: -CH=CR 7 R 8 , -C≡C-R 8 , -CH=CHCHR 7 R 8 , -(CHR 7 ) p CHR 7 R 8 , -(CHR 7 ) p CH=CR 7 R 8 , -(CHR 7 ) p C≡C-R 8 , - (CH 2 ) p phenyl substituted with 0-3 R 10 , and -(CH 2 ) p (C -5 cycloalkyl); R 3 is selected from: H, F, Cl, Br, I, -OH, -OCF 3 , -CN, -N0 2 , -CHO, -C(=0)CH , -C(=0)CF 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -CF 3 , -CH 3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 , R 4 is selected from: H, F, Cl, Br, I, -OH, OH, -OCF 3 , -CN, -N0 , -CHO, -C(=0)CH 3 , -C(=0)CF 3 , -C(=0)NH 2 , -C(=0)NHCH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHC(=0)0CH 3 , -C(=0)OCH 3 , -CF 3 , -CH 3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 ; R 5 is selected from H, F, Cl, Br, I, -OH, -CH 3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 ; R 6 is selected from: H, F, Cl, Br, I, -OH, -OCF 3 , -CN, -N0 , -CHO, -C(=0)CH 3 , -C(=0)CF 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -CF 3 , -CH 3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 ; R 7 , at each occurrence, is selected from H, methyl, ethyl, propyl, and butyl; R 8 , at each occurrence, is selected from: H, F, Cl, Br, I, CH(-OCH 2 CH 2 0-) , Cι_ 4 haloalkyl, C 1 - 4 alkyl substituted with 0-3 R 11 , C 2 - 4 alkenyl, C 3 - 6 cycloalkyl substituted with 0-2 R 9 , phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-3 heteroatoms selected from the group consisting of pyridinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, and oxazolidinyl; R 9 , at each occurrence, is selected from D, OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, and F; R 10 , at each occurrence, is selected from OH, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, F, Cl, Br, I, CN, -NH 2 , -NHCH 3 , -NHCH 2 CH 3 , -N(CH 3 ) 2 , -N(CH 2 CH 3 ) 2 , and C(=0)CH 3 ; R 11 , at each occurrence, is selected from OR 7 , CN, F, Cl, Br, I, N0 2 , -NH 2 , -NHCH 3 , -NHCH2CH 3 , -N(CH 3 ) 2 , -N(CH 2 CH 3 ) 2 , CHO, C(=0)CH 3 , C(=0)NH 2 ; R 12 , at each occurrence, is selected from Cι_ 6 alkyl, C 2 - 4 alkenyl, C2-4 alkynyl , C 3 - 6 cycloalkyl, phenyl substituted with 0-2 R 10 , and 5-6 membered aromatic heterocycle system containing from 1-3 heteroatoms selected from the group consisting pyridinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, and oxazolidinyl, - (CH 2 ) p phenyl substituted with 0-2 R 10 , and -(CH 2 ) p (C 3 _ 5 cycloalkyl); and p, at each occurrence, is selected from 0, 1, and 2. 8. A compound according to Claim 7 of Formula (Illb) (IHb) wherein: R l is selected from: -CF 3 , -CF 2 H, -CH 3 , -CH 2 CH 3 , -CH 2 CH 2 CH 3 , -CH 2 CH 2 CH 2 CH3, -CH(CH 3 ) 2 , -CH 2 CH(CH 3 ) 2 , -CH 2 CH 2 C (CH 3 ) 3 , -CH 2 CH 2 CH(CH 3 )CH 3 , -CH(=CH 2 )CH 3 , -CH 2 CH=CH 2 , -CH 2 -CH=C (CH 3 ) 2 , -CH 2 -C≡CH, -CH 2 -C≡CCH 3 , -CH 2 Ph, -cycPr, -CH 2 cycPr, -CH 2 CH 2 cycPr, -CO 2 CH 3 , -CO 2 CH 2 CH 3 , -CO 2 CH 2 CH 2 CH 3 , -CO 2 CH 2 CH 2 CH 2 CH 3 , -C0 2 CH(CH 3 ) 2 , -C0 2 CH 2 CH(CH3)2, -C0 2 CH 2 Ph, -C0 2 cycPr, -C0 2 CH 2 cycPr, -C0 2 CH 2 CH=CH 2 , -S0 2 CH 2 CH 3 , -S0 2 CH(CH 3 ) 2 , -COCH 3 , -COCH 2 CH 3 , -C0CH 2 CH 2 CH 3 , -COCH(CH 3 ) 2 , and -C0CH 2 CycPr; R 2 is selected from: benzyl, phenethyl, -CH 2 CH 2 cycPr, -C≡C-CH 3 , -C≡C-CF 3 , -C≡C-Et, -C≡C-iPr, -C≡C-cycPr, -C≡C-1- (CH 3 )cycPr, -C≡C-CH=CH 2 , -C≡C-C (=CH 2 ) CH 3 , -CH=CH-CH 3 , -CH=CH-CF 3 , -CH=CH-Et, -CH=CH-iPr, -CH=CH-cycPr , -CH=CH-CH=CH 2 , -CH 2 -C≡C-CH 3 , -CH 2 -C≡C-CF 3 , -CH 2 -C≡C-Et, -CH 2 -C≡C-iPr, -CH 2 -C≡C-cycPr, -CH 2 -C≡C-CH=CH 2 , -CH 2 -CH=CH 2 , -CH 2 -CH=CH-CH 3 , -CH 2 -CH=CH-CF 3 , -CH 2 -CH=CH-E t , -CH 2 -CH=CH-iPr, -CH 2 -CH=CH-cycPr , -CH 2 -CH=CH-CH=CH2, -CH 2 -CH=C(CH 3 )2, and -CH=CH-CH 2 -cycPr; R 3 is selected from: H, F, Cl, Br, I, -OH, -OCF 3 , -CN, -N0 2 , -C(=0)CH 3 , -C(=0)CF 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -CF 3 , -CH 3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 , R 4 is selected from: H, F, Cl, Br, I, -OH, OH, -OCF 3 , -CN, -N0 2 , -C(=0)CH 3 , -C(=0)CF 3 , -C(=0)NH 2 , -C(=0)NHCH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHC(=0)OCH 3 , -C(=0)OCH 3 , -CF 3 , -CH 3 , -CH 2 CH 3 , -OCH 3 , and -OCH 2 CH 3 ; R 5 is selected from H, F, and Cl; and R 6 is selected from: H, F, Cl -OH, -OCF 3 , -CF 3 , -CH 3 , and -OCH 3 . 9. A pharmaceutical composition, comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound according to one of Claims 1- 8. 10. A method for treating HIV infection, comprising: administering to a host in need of such treatment a therapeutically effective amount of a compound according to one of Claims 1-8, or a pharmaceutically acceptable salt form thereof . 11. A method of treating HIV infection which comprises administering, in combination, to a host in need thereof a therapeutically effective amount of: (a) a compound according to one of Claims 1-8; and, (b) at least one compound selected from the group consisting of HIV reverse transcriptase inhibitors and HIV protease inhibitors . 12. A method according to Claim 11, wherein, the reverse transcriptase inhibitor is a nucleoside reverse transcriptase inhibitor. 13. A method according to Claim 11, wherein, the HIV reverse transcriptase inhibitor is selected from AZT, 3TC, rescriptor, ddl, ddC, efavirenz, and d4T and the protease inhibitor is selected from saquinavir, ritonavir, indinavir, VX-478, nelfinavir, KNI-272, CGP-61755, and U-103017. 14. A method according to Claim 13 , wherein the HIV reverse transcriptase inhibitor is selected from AZT, rescriptor, efavirenz, and 3TC and the protease inhibitor is selected from saquinavir, ritonavir, indinavir, and nelfinavir. 15. A method according to Claim 14, wherein, the HIV reverse transcriptase inhibitor is AZT. 16. A method according to Claim 14, wherein, the HIV reverse transcriptase inhibitor is efavirenz . 17. A method according to Claim 14, wherein, the protease inhibitor is indinavir. 18. A compound according to Claim 1 of Formula (la) or (lb) : (la) (lb) or a stereoisomer or pharmaceutically acceptable salt form thereof .

Inventors: MCHUGH ROBERT JOSEPH, PATEL MONA, MCHUGH, ROBERT, JOSEPH, PATEL, MONA
Applicants: DU PONT PHARM CO, DU PONT PHARMACEUTICALS COMPANY
Application year: 1999
Main classification: C07D241
IPC codes: C07D241, C07D401, C07D405