BALLOON CATHETER WITH BALLOON INFLATION AT DISTAL END OF BALLOON AND STENT DELIVERY SYSTEM

Abstract: A balloon catheter is provided having an expandable distal portion (22), said expandable portion having a proximal end, a distal end and distal expansion means, said expandable portion being adapted for expansion at its distal end, from its distal end to its proximal end. A stent delivery system is provided to facilitate introduction and placement of a stent, and includes a catheter (112) having an expandable distal portion constructed and arranged for expanding the outer diameter of the catheter from a contracted state to an expanded state, said distal portion further comprising a balloon (122), and a stent (130) positioned around the distal portion of the catheter around the balloon, said stent having a proximal end and a distal end and further having a contracted condition, said stent being sized in the contracted condition to closely surround the balloon in the contracted state, and being adapted to expand to an expanded condition from its distal end to its proximal end in response to expansion of the balloon member from its distal end.

Description: BALLOON CATHETER WITH BALLOON INFLATION AT DISTAL END OF BALLOON AND STENT DELIVERY SYSTEM Background of the Invention The present invention relates generally to catheters having an expandable balloon and to premounted balloon expandable stent balloon catheters, and specifically to a balloon catheter with expansion means at the distal end of the balloon. The present invention is particularly directed to improved arrangements of the balloon member of a balloon catheter which provides inflation of the balloon from its distal end to its proximal end, and to improved arrangements of a stent delivery catheter which provides expansion of the stent from its distal end to its proximal end. Percutaneous transluminal coronary angioplasty (PTCA) is a procedure which is well established for the treatment of blockages in the coronary arteries. Blockages may occur from cholesterol precipitation on the coronary wall which may be in any stage from initial deposit through aged lesions. Coronary arteries may also become blocked due to formation of thrombus. Percutaneous transluminal angioplasty (PTA) is also a known treatment of body lumens. The most widely used form of percutaneous angioplasty makes use of a dilatation balloon catheter. In typical PTCA or PTA procedures, the cardiovascular system of a patient is accessed with an introducer, usually via the femoral artery or the radial artery. All other devices including a guiding catheter are percutaneously introduced into the cardiovascular system of a patient through the introducer and advanced through a vessel until the distal end thereof is at a desired location in the vasculature. A guide wire and a dilatation catheter having a balloon on the distal end thereof are introduced through the guiding catheter with the guide wire sliding through the dilatation catheter. The guide wire is first advanced out of the guiding catheter into the patient's coronary vasculature and the dilatation catheter is advanced over the previously advanced guide wire until the dilatation balloon is properly positioned across the lesion. Once in position across the lesion, the flexible, expandable, preformed balloon is inflated to a predetermined size with a fluid at relatively high pressures, such as greater than about four atmospheres, to radially compress or fracture the atherosclerotic plaque of the lesion against the inside of the artery wall and thereby dilate the lumen of the artery. The balloon is then deflated to a small profile so that the dilatation catheter may be withdrawn from the patients vasculature and blood flow resumed through the dilated artery. Following angioplasty procedures of the kind described above, there is a possibility of restenosis of the artery. Restenosis may necessitate either another angioplasty procedure, a surgical by-pass operation, or some method of repairing or strengthening the area. To reduce the likelihood of restenosis and strengthen the area, a physician can implant an intravascular prosthesis for maintaining vascular patency, called a stent, inside the artery at the lesion. In general, stents are prosthetic devices which can be positioned within a body cavity, for example, a blood vessel of the body of a living human or in some other difficulty accessible place. A stent generally has a variable diameter, which may be increased or decreased. Stents are particularly useful for permanently widening a vessel which is in a narrowed state, or for internally supporting a vessel damaged by an aneurysm. Such stents are typically introduced into the body cavity by use of a catheter. The catheter is usually of the balloon catheter type in which the balloon is utilized to expand the stent, which is positioned over the balloon, to place it in a selected location in the body cavity. The stent is expanded to a larger diameter for placement in the vasculature, often by the balloon portion of the catheter. Stents delivered to a restricted coronary artery, expanded to a larger diameter by a balloon catheter, and left in place in the artery at the site of a dilated lesion are shown in U.S. Patent 4,740,207 to Kreamer and U.S. Patent 5,007,926 to Derbyshire. One important characteristic of a dilatation balloon catheter is the manner in which the balloon inflates. Prior art balloon catheters are constructed such that the inflation fluid enters the balloon at the proximal end. The balloon catheter of the present invention provides a construction wherein the fluid enters the balloon at the distal end thereof, resulting in expansion of the balloon from its distal end to its proximal end. When used with balloon expandable stents, the balloon and balloon catheter of the present invention allows for the stents to dilate distally first and then expand proximally. Current designs have stents either "dumbbell", i.e. open at both ends, or open proximally first. The distal inflation provided by the present invention prevents the release or dislodgment of thrombus or plaque downstream. In addition, distal to proximal inflation serves to minimize vessel wall trauma resulting from stent "dumbbelling". Summary of the Invention It is a general object of the present invention to provide an improved medical balloon and a medical device incorporating a balloon. This invention concerns medical devices such as balloon catheters and apparatus suitable for delivery of stents to body cavities. The present invention is particularly directed to improved balloon catheters and to improved arrangements for balloon inflation, the improvement comprising distal balloon inflation means providing inflation from the distal end to the proximal end. Another object of the present invention is to provide an improved means and method for expanding a medical balloon (and a stent carried thereon) from the distal end to the proximal end. Accordingly, the present invention provides a catheter having an expandable distal portion constructed and arranged for expanding the outer diameter of the catheter from a contracted state to an expanded state. The distal portion of the catheter comprises a balloon which is folded or otherwise collapsed, and is expandable to an expanded condition by introduction of an inflation fluid. The balloon catheter may comprise an outer lumen with a balloon member attached to and/or extending distally therefrom, and an inner lumen extending the length of the outer lumen and distally therefrom through the interior portion of the balloon member. At its proximal end, the balloon member is positioned around the inner lumen and abuts the distal end of the outer lumen. The distal end of the outer lumen may be a second (softer, more , compliant) material bonded to the proximal end. The catheter is associated with a source of inflation fluid. Alternatively, where the balloon member is attached to the outer lumen, the outer lumen of the catheter may extend distally into the interior of the balloon member. At the distal portion of the balloon member, the catheter comprises a distal inflation port through which inflation fluid is introduced into the distal portion of the balloon. A separate inflation lumen may also be provided which extends through the catheter and comprises the distal inflation port. Where the catheter and balloon have a unitary construction, a separate inflation lumen is provided. It is also an object of the present invention to provide an improved means and method for delivery of a stent via a catheter having an expandable balloon which expands from the distal to the proximal end. Accordingly, the present invention also provides a catheter balloon having an expandable distal portion constructed and arranged for expanding the outer diameter of the stent from its distal end to its proximal end. The present invention also provides a stent delivery system including a catheter balloon having an expandable distal portion constructed and arranged for expanding the outer diameter of the stent from a contracted state to an expanded state from its distal end first. A stent is positioned around the distal portion of the catheter and over the balloon. The balloon catheter of the present invention, when used with balloon expandable stents, allows for the stents to dilate distally first and then expand proximally. Prior art catheter balloons, however, cause the stents to either open proximally first, or "dumbbell", i.e. expand from both ends to the center when the balloon inflates. Important advantages are provided by the distal to proximal inflation provided according to the present invention. Distal inflation prevents the release or dislodgment of thrombus or plaque downstream. In addition, distal to proximal inflation serves to minimize vessel wall trauma resulting from stent "dumbbelling". Brief Description of the Figures Figure 1 is a perspective view of a balloon catheter according to the present invention, the catheter being of the monorail or single operator exchange (SOE) type, with the distal portion of the catheter shown in larger scale than the proximal portions and showing a balloon inflation means located at the distal end thereof; Figure 2 is a perspective view of the proximal section of an alternative catheter of the over the wire type, with which the balloon of the present invention may be utilized; Figure 3 is an enlarged view in longitudinal cross-section of the distal portion of the catheter of Figure 1 (indicated by dashed circle 3 at Figure 1); Figure 4 is a longitudinal cross section of an alternative embodiment of the distal portion of the catheter of the present invention; Figures 5A-5C are alternative cross sectional views along line 5-5 at Figure 2; Figure 6 is a longitudinal cross section of an alternative embodiment of the distal portion of the catheter of the present invention; Figures 7A-7B are cross sectional views of alternative embodiments along line 7-7 at Figure 6; Figure 8A is a longitudinal cross section of an alternative embodiment of the distal portion of the catheter of the present invention, and Figure 8B is a fragmentary cross section of an alternative embodiment of the distal portion of the balloon thereof; Figure 9 is a longitudinal cross section of an alternative embodiment of the distal portion of the catheter of the present invention; Figure 10 is a longitudinal cross section of an alternative embodiment of a balloon according to the present invention. Figure 11 is a longitudinal cross section of a further alternative embodiment of the distal portion of the catheter of the present invention; Figures 12 - 16 are longitudinal section views of expansion of the balloon member of the catheter of the present invention; Figure 17 is a longitudinal cross section of an alternative embodiment of a balloon according to the present invention; and Figures 18 - 22 are longitudinal section views of delivery of a stent by a stent delivery catheter according to the present invention. Detailed Description of the Invention Referring to Figures 1-5, a medical device comprising a balloon catheter with a balloon member according to the present invention is generally indicated at 10. Figure 1 is a longitudinal section view of a balloon catheter with a balloon according to the present invention, wherein the balloon inflation means is located at the distal portion of the balloon thereof. As shown at Figure 1, catheter 12 has a shaft 13, a proximal portion 14 and a distal portion, indicated generally at 16. The catheter shown at Figure 1 is a monorail or single operator exchange (SOE) type catheter. A perspective view of an alternative embodiment of proximal portion 14 is shown at Figure 2, specifically an over the wire type catheter device. It is understood that any suitable catheter known in the art including but not limited to monorail, SOE or over the wire type catheters may be used according to the present invention. Distal portion 16 is shown at Figure 1 in longitudinal section view which is enlarged relative to the view of the proximal portion of said catheter. Distal portion 16 is fixed to catheter 12 by standard means known in the art. For instance, distal portion 16 may be bonded, by adhesive or any kind of bonding technologies including but not limited to heat bonding, to the catheter in an integral manner. Alternatively, distal portion 16 may be may be of unitary construction, i.e. made one-piece with the catheter as is known in the art. Distal end portion 16 comprises balloon 22, which is constructed and arranged for expansion from a contracted state to an expanded state. Balloon 22 may be of any length. For instance, balloon 22 may be about 15 mm long. This length, however, is for illustrative purposes only and is not meant to be limiting. Balloon 22 is shown in a partially inflated state in Figures 1, 3, 6, 8-11 and 16. Balloon 22 may be contracted, folded or otherwise collapsed. Balloon 22 may be made of a material which resiliently deforms under radial pressure. Examples of suitable materials are generally known in the art and include non-compliant, semi-compliant and compliant materials such as polyethylene (PE), nylon, polyamide, polyether block amides (PEBAX), polyethylene terephthalate (PET), silicone, POC, polypropylene, polyether block PBT and the like. In addition, balloon 22 may be formed of multiple layers of these materials and/or coextruded. Further, balloon 22 may comprise fiber reinforcements, such as are disclosed in U.S. Patent Application No. 08/817,165 incorporated herein by reference. Balloon 22 may be provided with a distal end 25 made of a second softer more compliant material bonded to the proximal end 27. The balloon may be integrally molded with the catheter (as shown at Figure 10) or bonded to the catheter shaft (as shown at Figures 4, 6, 8 and 9). Where a separate balloon is provided, it is bondable to the catheter by any suitable adhesive, for example, epoxy adhesives, urethane adhesives, cyanoacrylates, and other adhesives suitable for bonding nylon or the like, as well as by hot melt bonding, ultrasonic welding, heat fusion or the like. Alternatively such a balloon may be attached to the catheter by mechanical means such as swage locks, crimp fittings, threads and the like. Where the catheter is separate from the balloon (and bonded thereto), the catheter may be made of high density or low density polyethylene, nylons, Pebax, Grilamid, Vestamid, Cristamid, or combinations thereof. The catheter shaft could also be made of a metal, such as stainless steel (ss hypotube, for example), Nitinol or the like, optionally with a lubricious exterior added thereto, such as a hydrophilic coating (for example, as described in U.S. Patent No. 5,693,034, incorporated herein by reference) or silicone coating. In use, balloon 22 has a larger diameter which is obtained when the balloon 22 is expanded. Figure 15 shows distal end portion 16 in an even more enlarged longitudinal cross-sectional view, in use. Catheter balloon 22 is inflated by fluid (gas or liquid) from distal inflation port 24 (shown at Figures 3 and 4) extending from inflation lumen 26 contained in the catheter shaft 13 and opening into the distal portion of balloon 22. As shown at Figure 1 , the catheter may be associated with a source of fluid (gas or liquid) external to the catheter and associated therewith, whereby the fluid is delivered to the balloon or expandable member by inflation lumen 26 located in the catheter shaft 13 and associated with distal portion of balloon 22. Figure 5A-5C are cross sections of balloon 22 along line 5-5 of Figure 1, showing interior 23 of balloon 22, inflation lumen 26, the interior 28 of inflation lumen 26, and optional guide wire lumen 42. As shown at Figures 3, 4 and 5 A, balloon 22, inflation lumen 26 and guide wire lumen 42 have a coaxial configuration. Figures 5B and 5C show a dual-lumen configuration which may be formed in a single extrusion process. Lumens 26 and 42 as shown at Figure 5B are of a circular cross section. Alternatively, as shown at Figure 5C lumens 26 and 42 may be of a semicircular cross section. • Referring now to Figure 6, an alternative embodiment of the catheter having a dual-lumen configuration is shown. Figures 7A-7B are cross sectional views of alternative embodiments taken along line 7-7 of Figure 6. As exemplified by Figure 7A, the dual lumen configuration may be formed in a single extrusion process. Alternatively, two individual tubes may be joined together by an adhesive joint or a thermal process. Figure 7B shows two individual tubes. A single extrusion, dual lumen tubing is the preferred configuration. Balloon 22 may be distally inflated by other means, such as from fluid communication at its distal end from a passageway or passageways formed between the outside of the catheter shaft and the membrane forming the balloon, depending on the design of the catheter. An example of a balloon having a passageway formed between the outside of the catheter shaft and the membrane forming the balloon is shown at Figure 8A. Such a passageway could lead from the catheter shaft directly to the interior of the balloon via a conduit ending at the distal portion of the balloon, as shown at Figure 6. Alternatively, the passageway could lead to the exterior of the balloon to an exterior distal inflation port 24', as shown in Figure 9. In addition, the passageway could lead not only to the interior of the balloon, but also to a distal inflation compartment located at the distal end of the balloon. A distal inflation compartment may be provided between the interior and exterior surfaces of the balloon, as shown at 60 of Figure 8B. Although distal inflation compartment 60 is shown with the passageway formed between the outside of the catheter shaft and the membrane forming the balloon, a distal inflation compartment may be provided which communicates with any inflation means disclosed herein. Referring to Figure 10, distal inflation compartment 60' may alternatively be provided as part of interior 23 of balloon 22 separated from the remainder of the balloon interior. Figure 11 is an alternative embodiment wherein balloon 22 and shaft 13 of catheter 12 are unitary in construction. Figures 12-16 are longitudinal section views of expansion of the balloon member of the catheter of the present invention. Catheter 12 as shown at Figures 12-16 includes optional guide wire 40 and guide wire lumen 42. The details and mechanics of balloon inflation and specific overall catheter construction will vary according to the design of the catheter, and are known in the art per se. All of these variations are acceptable for use with the balloon catheters and stent delivery systems of the present invention. As shown in Figures 12 and 13, the inflation of balloon 22 is accomplished through delivery of the inflation fluid to the interior 23 of balloon 22 via distal inflation means 24 which comprises an inflation port located on the inflation lumen. At Figures 14-15, the inflation means is a port located at the distal end of the inflation lumen. Inflation means 24 communicates with the interior 23 of balloon 22, delivering inflation fluid to the interior 23 which inflates balloon 23 distally from the distal end to the proximal end thereof as shown at Figures 12 and 14. At Figures 12-15, balloon is shown expanding against arterial plaque 55 in vessel 50. Figure 16 shows site 100 after deflation of balloon 22. Alternatively, the inflation of the balloon could be controlled by providing graduated balloon wall thickness, or through modification of the heat set temperature of the balloon material. The more compliant distal portion would expand first. An example of a balloon with graduated wall thickness is shown at Figure 17. A balloon of a material which has a modified heat set temperature such that the balloon will inflate at its distal end first and inflate from the distal end to the proximal end thereof will appear substantially like the balloons shown in the other figures herein. The placement of the inflation means of such embodiments could be provided along any portion of the balloon, as the distal to proximal inflation is controlled in this embodiment by the balloon and balloon material itself. Any balloon inflation means known in the art including those which are proximally located with respect to the balloon may be employed in these embodiments. The process and equipment for forming the balloon are known in the art. An example of such process and equipment is set forth in U.S. Patent , incorporated herein by reference. Referring to Figures 18-22, stent delivery catheter with a balloon member according to the present invention is shown. Figures 18-19 show an inflation means as in Figures 12-13 and Figures 20-21 show an inflation means as in Figures 14- 15. Expansion of the balloon from the distal end to the proximal end results in the expansion of the stent from the distal end to the proximal end thereof. Catheter 112 is shown in Figures 18-22 having an optional guide wire 140 and guide wire lumen 142. Stents which may be used with this invention include plastic and metal stents, many of which are known in the art. Some are more well known such as the stainless steel stent shown in U.S. Patent 4,735,665; the wire stent shown in U.S. Patent 4,950,227; another metal stent shown in European Patent Application EP0 707 837 Al and that shown in U.S. Patent 5,445,646. All of these patents are incorporated herein by reference. Also, shape memory metal stents and/or self expanding stents may be used. Stent 130 is typically about 15mm long, while balloon 122 is roughly the same length. These dimensions, however, are merely representative for illustrative purposes only and are not meant to be limiting. Stent 130 has a contracted condition and an expanded condition, being sized in its contracted condition to closely surround the catheter. Stent 130 is fixed about balloon 122 by any suitable means as known in the art. For example, stent 130 may be gently crimped onto balloon 122 either by hand or with a tool such as a pliers or the like to be mounted for delivery. Further securement may be provided, such as hubs, proximal and distal socks, for example, as set forth in U.S. Patent 4,950,227 to Savin, incorporated herein by reference, and the like, or other stent securement means known in the art. Where the distal portion of the outer lumen of the catheter 112 extends through the interior of balloon 122, the distal portion of the outer lumen, it provides - additional surface area to facilitate stent crimping. Stent 130 has a larger expanded diameter which is obtained when the balloon 122 is expanded. That is, stent 130 will be released from catheter 1 12 upon expansion of balloon 122 to be placed in a vessel. Balloon 122 and stent 130 are shown expanding against arterial plaque 155. When balloon 122 is then deflated, removal of catheter 112 may be accomplished while leaving stent 130 in place. Catheter balloon 122 may be inflated by fluid (gas or liquid) from a distal inflation port extending from a lumen contained in the catheter shaft 113 and opening into the distal end portion of balloon 122, or by other means, such as from fluid communication from a passageway formed between the outside of the catheter shaft 113 and the membrane forming the balloon, depending on the design of the catheter. The catheter may be associated with a source of fluid (gas or liquid) external to the catheter, whereby the fluid is delivered to the balloon or expandable member by an inflation lumen located in the catheter shaft 113 and associated with the distal end portion of balloon 122. At Figure 22, stent 130 is shown in place in implant site 100 after the balloon has been deflated. Alternatively, the expansion of the stent could be accomplished by providing a balloon having its expansion controlled by providing a graduated balloon wall thickness as shown at Figure 17, or through modification of the heat set temperature of the balloon material. The more compliant distal portion of the balloon would expand first, resulting in expansion of the stent from the distal end to the proximal end. The placement of the inflation means of such an embodiment could optionally be provided at any portion of the balloon, as the distal to proximal inflation is controlled in this embodiment by the balloon material itself. Any proximal balloon inflation means known in the art may be employed in this embodiment. The details and mechanics of balloon inflation and deflation and specific overall catheter construction will vary according to the design of the catheter, and are known in the art per se. All of these variations are acceptable for use with this invention. Important advantages are provided by the distal to proximal inflation provided according to the present invention. Distal inflation prevents the release or dislodgment of thrombus or plaque downstream. In addition, distal to proximal inflation serves to minimize vessel wall trauma resulting from stent "dumbbelling". The above Examples and disclosure are intended to be illustrative and not exhaustive. These examples and description will suggest many variations and alternatives to one of ordinary skill in this art. All these alternatives and variations are intended to be included within the scope of the attached claims. Those familiar with the art may recognize other equivalents to the specific embodiments described herein which equivalents are also intended to be encompassed by the claims attached hereto.

Claims: WHAT IS CLAIMED IS AS FOLLOWS: 1. A catheter balloon having a proximal end, a distal end and an interior portion, said balloon being adapted for expansion from a distal end thereof. 2. The balloon of claim 1 having a graduated wall thickness, wherein the wall thickness of the balloon at its proximal end is greater than the wall thickness of the balloon at its distal end. 3. The balloon of claim 1 further comprising an exterior wall and an interior wall, and a distal expansion compartment located between said interior and exterior walls. 4. The balloon of claim 1 further comprising an interior wall defining a distal interior expansion compartment. 5. A medical device comprising: a catheter comprising a proximal portion, a distal portion, a shaft and an expandable member located at the distal portion, said expandable member being constructed and arranged for expanding the outer diameter of said catheter from a contracted state to an expanded state, said expandable member being adapted for expansion from a distal end thereof. 6. The medical device of claim 5 further comprising expansion means associated with the expandable member, said expansion means being adapted to provide expansion of the expandable member from the distal end thereof. 7. The medical device of claim 6 wherein the expandable member comprises a balloon having an inflation port at the distal end thereof and the expansion means comprises an inflation lumen associated with a source of inflation fluid, said inflation lumen communicating with the distal portion of the balloon through said inflation port. 8. The medical device of claim 7 wherein the inflation lumen extends through the interior portion of the balloon. 9. The medical device of claim 7 wherein the inflation lumen is exterior of the balloon. 10. The medical device of claim 6 wherein the expandable member comprises a balloon made of a material which resiliently deforms under radial pressure. 11. The medical device of claim 10 wherein the balloon is made of a material selected from the group consisting of elastomeric materials, non-compliant materials, semi-compliant materials and compliant materials. 12. The medical device of claim 11 wherein the balloon is made of at least one material selected from the group consisting of polyethylene (PE), nylon, polyamide, polyether block amides (PEBAX), polyethylene terephthalate (PET), silicone, POC, polypropylene, polyether block PBT and the like. 13. The medical device of claim 11 wherein the balloon further comprises a proximal portion and a distal portion, and said distal portion is made of a material which is relatively more compliant that the material of which the proximal portion is made. 14. The medical device of claim 12 wherein the balloon is formed of multiple layers. 15. The medical device of claim 12 wherein the balloon is coextruded. 16. The medical device of claim 6 wherein the catheter is made of a material selected from the group consisting of high density polyethylene, low density polyethylene, nylons, Pebax, Grilamid, Vestamid, Cristamid, and combinations thereof. 17. The medical device of claim 6 wherein the catheter shaft is made of a metal selected from the group consisting of stainless steel and Nitinol. 18. The medical device of claim 17 wherein the catheter shaft has an exterior lubricious coating selected from the group consisting of hydrophilic coatings and silicone coating. 19. A stent delivery system comprising: a catheter comprising a proximal portion, a distal portion, a shaft and an expandable balloon located at the distal portion, said balloon having a proximal end and a distal end and being constructed and arranged for expanding the outer diameter of said balloon from a contracted state to an expanded state, said balloon being adapted for expansion from a distal end thereof; a radially expandable stent of generally cylindrical configuration positioned around said distal portion of said catheter around the balloon, said stent having a contracted condition, being sized in the contracted condition to closely surround the balloon in the contracted state, and further being expandable to an expanded condition; expansion means associated with the balloon for expansion of the balloon from the distal end thereof first and in a proximal direction, whereby said stent is adapted for expansion from a distal end thereof to a proximal end thereof in response to the expansion of the balloon and release of the stent by expansion of the balloon. 20. The stent delivery system of claim 19 wherein the balloon is made of a material which resiliently deforms under radial pressure. 21. The stent delivery system of claim 19 wherein the stent is crimped to the balloon for delivery. 22. A system for intraluminal delivery of a stent comprising: a balloon catheter comprising a shaft, a balloon associated with a distal portion of the shaft for receiving a stent, the shaft further comprising an inflation lumen associated with the distal end of the balloon for distal inflation thereof and release of a stent mounted to the catheter for delivery by expansion of the balloon.

Inventors: DICAPRIO FERNANDO, DICAPRIO, FERNANDO
Applicants: SCIMED LIFE SYSTEMS INC, SCIMED LIFE SYSTEMS, INC.
Application year: 1999
Main classification: A61L29
IPC codes: A61F2, A61L29, A61M25