PROCOLLAGEN C-PROTEINASE INHIBITORS

Abstract: This invention relates to compounds of Formula (I) wherein R<1>-R<7>, A, Z and n are as described in the summary of the invention that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for their preparation.

Description: Procollagen C-proteinase Inhibitors The present invention relates to compounds that inhibit procollagen C- proteinase, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds. The collagens are integral components of connective tissue. At present nineteen types of collagens have been identified. The interstitial collagen types I, and HI are the major collagen components of tissue. These collagens are synthesized as procollagen precusor molecules having amino- and carboxy-terminal peptide extensions also known as pro-regions. These pro-regions arc typically cleaved upon secretion of the procollagen molecule to give a mature collagen molecule which is capable of association into highly structured collagen fibers, (sec, e.g., Fcssler and Fessler, Anna. Rev. Biochem. 47, 129, (1978); Kivirikko et al., Extracellular Matrix Biochemistry ( 1984) and Kuhn, Structure and Function of Collagen Types (eds Maync, R and Burgeson, R. EN Academic Press, Inc., Orlando, Florida pp 1-42 (1987). Excessive collagen deposition is associated with a variety of fibrotic diseases such as interstitial pulmonary fibrosis, pericentral fibrosis, Symmers' fibrosis, perimuscular fibrosis, kidney fibrosis, endocardial sclerosis, hepatitis, acute respiratory distress syndrome, arthritis, cystic fibrosis, surgical adhesions, tendon surgery, corneal scarring, scleroderma, chronic allograft rejection, hemodialysis shunt fibrosis and restenosis. These diseases are characterized by excessive deposits of fibrillar interstitial collagens that are resistant to proteolyic degradation thus leading to the symptoms of fibrosis. Therefore, inhibition of the pathological deposition of these collagens should help in the treatment of these diseases. Recent studies suggest that procollagen C-proteinase is the essential enzyme that catalyzes the cleavage of the C-propeptide of types I, H and HI collagens and therefore instrumental in the formation of functional collagen fibers ((see, Fertala et al., /. Biol. Chem., 269, 11584, (1994)). It would therefore be desirable to provide procollagen C-proteinase inhibitors and thereby provide a means of combating diseases mediated by excessive deposition of these collagens. It is therefore in a first aspect, an object of the present invention to provide hydroxamic acids selected from the group of compounds represented by Formula (I): (I) wherein: R 1 and R 4 are, independently of each other, hydrogen or alkyl; R 2 is: (i) cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heteroaralkenyl, heterocyclo or heterocycloalkyl; or (ii) -(alkylene)-B-X where B is -O-, -NR 8 -, -S(O) n - (where n is 0, 1 or 2), -C=O, -CONR 8 -, -NR 8 CO 2 -, NR 8 SO 2 - or -C(=NR 8 )NR 8 SO 2 -(where R 8 is H or alkyl), and X is cycloalkyl, cycloalkylalkyl, aryl, aralkyl heteroaryl or heteroaralkyl; or (iii) -(alkylene)-B-X where B is -NR 8 CO- (where R 8 is H or alkyl), and X is cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; or (iv) R 2 and R 3 form an alkyl ene or heteroalkylene chain; R 3 is hydrogen or alkyl; R 6 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; R 5 is: (i) hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heteroaralkenyl, heterocycloalkyl, heteroalkyl, or -(alkylene)-C(O)-X' where X 1 is alkyl, hydroxy, alkoxy, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy, heteroaralkyloxy or NR'R" (where R' and R" are independently H or alkyl, or R'and R" form an alkylene chain); or (ii) R 5 and R 4 form an alkylene chain; or (iii) R 5 and R 6 form an alkylene chain; n is 0 or 1; A is -C(=O)-CH(R 9 )-(CH 2 ) m -N(R 10 )- wherein: m is an integer from 0-5 inclusive; R 9 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heteroalkyl, or -(alkylene)-C(O)-X' where X 1 is alkyl, hydroxy, alkoxy, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy, heteroaralkyloxy or NR'R" (where R' and R" are independently H or alkyl, or R' and R" form an alkylene chain); and R 10 is hydrogen, alkyl, aralkyl or heteroaralkyl; Z is Y-B wherein: Y is alkylene or a bond; and B is -CO-, -C(O)O-, -CONR 8 -, -SO 2 -, or -SO 2 NR 8 - (where R 8 is hydrogen or alkyl), alkylene (optionally substituted by hydroxy, alkoxy, amino, monoalkylamino or dialkylamino) or a bond; R is cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; provided that when n = 0 and Z is SO , then R 2 does not contain an imidazole group; and their pharmaceutically acceptable salts, prodrugs, individual isomers, and mixtures of isomers. In a second aspect, this invention provides a method of treatment of a disease in a mammal treatable by administration of a procollagen C-proteinase inhibitor selected from the group of compounds represented by Formula (I): In a third aspect, this invention provides pharmaceutical compositions containing a therapeutically effective amount of a compound of Formula (I) or its pharmaceutically acceptable salt and a pharmaceutically acceptable excipient. In a fourth aspect, this invention provides a method of treating disease by administering to a patient a selective inhibitor of procollagen-C-proteinase. In a fifth aspect, this invention provides a method of preparing compounds of Formula (I). Unless otherwise stated, the following terms used in the specification and claims have the meanings given below: "Alkyl" means a linear saturated monovalent hydrocarbon radical of one to six carbon atoms or a branched saturated monovalent hydrocarbon radical of three to six carbon atoms, e.g., methyl, ethyl, propyl, 2-propyl, pentyl, and the like. "Alkylene" means a linear saturated divalent hydrocarbon radical of one to six carbon atoms or a branched saturated divalent hydrocarbon radical of three to six carbon atoms, e.g., methylene, ethylene, propylene, 2-methylpropylene, pentylene, and the like. "Heteroalkylene" means an alkylene chain in which one methylene group has been replaced by O, S or NR' (where R' is hydrogen or alkyl.) "Alkenyl" means a linear monovalent hydrocarbon radical of two to six carbon atoms or a branched monovalent hydrocarbon radical of three to six carbon atoms, containing at least one double bond, e.g., ethenyl, propenyl, and the like. "Alkenylene" means a linear divalent hydrocarbon radical of two to six carbon atoms or a branched monovalent hydrocarbon radical of three to six carbon atoms, containing at least one double bond, e.g., ethenylene, 2-propenylene, and the like. "Acyl" means a radical -C(O)R where R is hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, haloalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heteroaralkenyl, or heterocyclo, e.g., acetyl, benzoyl, thenoyl, and the like. "Acyloxy" means a radical -OC(O)R where R is hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, or haloalkyl, e.g., acetoxy, 3,3,3- trifluoroacetoxy and the like. "Acylamino" means a radical -NRC(O)R ' where R is hydrogen or alkyl and R ' is hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, heteroalkyl, haloalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkenyl, or heteroaralkyl, e.g., acetylamino, trifluoroacetylamino, benzoylamino, methylacetylamino, and the like. "Sulfonylamino" means a radical -NRSO R ' where R is hydrogen or alkyl and R ' is alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, heteroalkyl, haloalkyl, amino, monosubstituted amino, disubstituted amino, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkenyl, or heteroaralkyl, e.g., methylsulfonylamino, benzylsulfonylamino, N-methylaminosulfonylamino, and the like. "Halo" means fluoro, chloro, bromo, or iodo, preferably fluoro and chloro. "Haloalkyl" means alkyl substituted with one or more same or different halo atoms, e.g., -CH 2 C1, -CF 3 , -CH 2 CF 3 , -CH 2 CC1 3 , and the like. " Cycloalkyl " means a saturated monovalent cyclic hydrocarbon radical of three to six ring carbons, e.g., cyclopropyl, cyclopentyl, cyclohexyl, and the like. " Carbocycle " means a saturated, cyclic group of 3 to 8 ring atoms in which all the ring atoms are carbon, e.g., cyclopentyl, cyclohexyl, and the like. "Aryl" means a monovalent monocyclic or bicyclic aromatic hydrocarbon radical of 6 to 10 ring atoms, optionally fused to a carbocycle or heterocycle, and optionally substituted independently with one or more substituents, preferably one or two substituents selected from alkyl, heteroalkyl, haloalkyl, halo, nitro, acyloxy, cyano, cycloalkyl, cycloalkylalkyl, optionally substituted phenyl, optionally substituted phenylalkyl, heteroaryl, heteroaralkyl, -OR (where R is hydrogen, alkyl, haloalkyl, alkenyl, cycloalkyl, cycloalkylalkyl, optionally substituted phenyl, heteroaryl, optionally substituted phenylalkyl, or heteroaralkyl), -NRR' (where R and R' are independently hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl, cycloalkylalkyl, optionally substituted phenyl, optionally substituted phenylalkyl, optionally substituted phenylalkenyl, heteroaryl, or heteroaralkyl), -C(O)R (where R is hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, haloalkyl, optionally substituted phenyl, optionally substituted phenylalkyl, optionally substituted phenylalkenyl, heteroaryl, heteroaralkyl, or heteroaralkenyl), -S(O) n R (where n is an integer from 0 to 2 and R is hydrogen (provided that n is 0), alkyl, haloalkyl, alkenyl, cycloalkyl, cycloalkylalkyl, optionally substituted phenyl, heteroaryl, optionally substituted phenylalkyl, or heteroaralkyl), -SO 2 NRR' (where R and R' are independently hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl, cycloalkylalkyl, optionally substituted phenyl, optionally substituted phenylalkyl, optionally substituted phenylalkenyl, heteroaryl or heteroaralkyl, or R and R' together with the nitrogen they are attached to form a cycloamino ring), -COOH, -(alkylene)-COOH, -(alkenylene)-COOH, - COOR a , -(alkenylene)-COOR\ -(alkylene)-COOR 3 (where R a is alkyl, optionally substituted phenylalkyl, or heteroaralkyl), -CONR ' R " , -(alkylene)-CONR ' R " , (where R ' and R" are independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, optionally substituted phenyl, optionally substituted phenylalkyl, heteroaryl and heteroaralkyl, or R' and R" together with the nitrogen they are attached to form a cycloamino ring), -NRC(O)R ' (where R is hydrogen or alkyl and R ' is hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, haloalkyl, optionally substituted phenyl, optionally substituted phenylalkyl, optionally substituted phenylalkenyl, heteroaryl, heteroaralkenyl, or heteroaralkyl), -NRSO 2 R ' (where R is hydrogen or alkyl and R ' is alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, haloalkyl, optionally substituted phenyl, optionally substituted phenylalkyl, optionally substituted phenylalkenyl, heteroaryl, heteroaralkenyl, or heteroaralkyl), or - NRSO 2 NR'R" (where R is hydrogen or alkyl and R' and R" are independently hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl, cycloalkylalkyl, optionally substituted phenyl, optionally substituted phenylalkyl or optionally substituted phenylalkenyl, or R' and R" together with the nitrogen they are attached to form a cycloamino ring). More specifically the term aryl includes, but is not limited to, phenyl, 1-naphthyl, 2- naphthyl, tetrahydronaphthyl, methylenedioxyphenyl, indanyl, tetralyl, indolinyl, chromanyl, isochromanyl and the like. " Heteroaryl " means a monovalent monocyclic or bicyclic aromatic radical of 5 to 10 ring atoms containing one, two, or three ring heteroatoms selected from N, O, or S, the remaining ring atoms being C. The heteroaryl ring is optionally substituted independently with one or more substituents, preferably one or two substituents, selected from alkyl, haloalkyl, halo, nitro, cyano, cycloalkyl, cycloalkylalkyl, optionally substituted phenyl, optionally substituted phenylalkyl, -OR (where R is hydrogen, alkyl, haloalkyl, alkenyl, cycloalkyl, cycloalkylalkyl, optionally substituted phenyl or optionally substituted phenylalkyl), -NRR' (where R and R' are independently hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl, cycloalkylalkyl, optionally substituted phenyl, optionally substituted phenylalkyl or optionally substituted phenylalkenyl, or R and R" together with the nitrogen they are attached to form a cycloamino ring), -C(O)R (where R is hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, haloalkyl, optionally substituted phenyl, optionally substituted phenylalkyl, or optionally substituted phenylalkenyl), -S(O) n R (where n is an integer from 0 to 2 and R is hydrogen (provided that n is 0), alkyl, haloalkyl, alkenyl, cycloalkyl, cycloalkylalkyl, optionally substituted phenyl, or optionally substituted phenylalkyl), -SO NRR' (where R and R' are independently hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl, cycloalkylalkyl, optionally substituted phenyl, optionally substituted phenylalkyl or optionally substituted phenylalkenyl, or R and R" together with the nitrogen they are attached to form a cycloamino ring), -COOH, -(alkylene)- COOH,-(alkenylene)COOH, -COOR a , -(alkenylene)-COOR a , -(alkylene)-COOR a (where R a is alkyl, or optionally substituted phenylalkyl), -CONR ' R " , -(alkylene)- CONR ' R " , (where R ' and R " are independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, optionally substituted phenyl and optionally substituted phenylalkyl, or R' and R" together with the nitrogen they are attached to form a cycloamino ring), -NRC(O)R ' (where R is hydrogen or alkyl and R ' is hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, haloalkyl, optionally substituted phenyl, optionally substituted phenylalkyl, or optionally substituted phenylalkenyl), - NRSO 2 R ' (where R is hydrogen or alkyl and R ' is alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, haloalkyl, optionally substituted phenyl, optionally substituted phenylalkyl, or optionally substituted phenylalkenyl), -NRSO 2 NR'R" (where R is hydrogen or alkyl and R' and R" are independently hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl, cycloalkylalkyl, optionally substituted phenyl, optionally substituted phenylalkyl or optionally substituted phenylalkenyl, or R' and R" together with the nitrogen they are attached to form a cycloamino ring), or an amino protecting group. More specifically the term heteroaryl includes, but is not limited to, furyl, thienyl, pyrroly, pyridyl, purinyl, pyrimidinyl, pyrazolyl, thiazolyl, imidazolyl, thiazolyl, thiadiazolyl, indolyl, azaindolyl, benzofuranyl, benzimidazolyl, benzthiazolyl, quinolinyl, isoquinolinyl, benzotriazolyl, benzopyranyl, 1, and the derivatives thereof. " Optionally substituted phenyl " means phenyl ring which is optionally substituted with one or more substituents, preferably one or two substituents selected from alkyl, haloalkyl, halo, nitro, cyano, -NRR ' (where R and R ' are independently selected from hydrogen and alkyl, or R and R' together with the nitrogen they are attached to form a cycloamino ring), -OR (where R is hydrogen, alkyl or haloalkyl), - COOR a (where R a is hydrogen or alkyl) or -CONR ' R " (where R ' and R " are independently selected from hydrogen and alkyl, or R' and R" together with the nitrogen they are attached to form a cycloamino ring). Representative examples include, but are not limited to, 4-fluorophenyl, 3,4-dibromophenyl, 4-chloro-2,5- dimethylphenyl, 2,4,5-trichlorophenyl, 4-bromo-2-trifluoromethoxyphenyl, 2-chloro- 4-trifluoromethyl, 4-tertbutylphenyl, 4-methoxyphenyl, 3-nitrophenyl, and the like. " Heterocycle " or " Heterocyclo " means a saturated cyclic radical of 3 to 8 ring atoms in which one or two ring atoms are heteroatoms selected from N, O, or S(O) n (where n is an integer from 0 to 2), the remaining ring atoms being C, where one or two C atoms may optionally be replaced by a carbonyl group. The heterocyclo ring may be optionally substituted independently with one, two, or three substituents selected from alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, halo, cyano, acylamino, amino, monosubstituted amino, disubstituted amino, -OR (where R is hydrogen, alkyl, haloalkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl), -C(O)R (where R is hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, haloalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, or heteroaralkenyl), -S(O) n R [where n is an integer from 0 to 2 and R is hydrogen (provided that n is 0), alkyl, haloalkyl, alkenyl, cycloalkyl, cycloalkylalkyl, amino, monosubstituted amino, disubstituted amino, aryl, heteroaryl, aralkyl, or heteroaralkyl], -COOH, -(alkylene)-COOH, -COOR a , - (alkylene)-COOR 3 (where R a is alkyl, heteroalkyl, aralkyl, or heteroaralkyl), - CONR ' R " , -(alkylene)-CONR ' R " (where R ' and R " are independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl and heteroaralkyl, or R' and R" together with the nitrogen they are attached to form a cycloamino ring) or an amino protecting group. More specifically the term heterocyclo includes, but is not limited to, tetrahydropyranyl, piperidino, piperazino, morpholino and thiomorpholino, thiomorpholino-1 -oxide, thiomorpholino-1,1- dioxide, and the derivatives thereof. The term "cycloamino" means a heterocyclo group in which at least one ring atom is nitrogen. Specific examples include piperidine, piperazine, morpholine, thiamorpholine, thiamorpholine sulfoxide and thiamorpholinesulphone. "Heteroalkyl" means an alkyl, cycloalkyl, or cycloalkylalkyl radical as defined above, carrying a substituent selected from -NR a R , -OR c , or -S(O) n R d , wherein: n is an integer from 0 to 2, R is hydrogen, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heteroaralkenyl, or acyl; R b is hydrogen, alkyl, aryl, aralkyl, acyl, -SO R (where R is alkyl, haloalkyl, amino, monosubstituted amino or disubstituted amino), -COOR (where R is alkyl, aralkyl, or heteroaralkyl), -CONR ' R " , -(alkylene)CONR ' R " (where R ' and R " are independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl and heteroaralkyl, or R' and R" together with the nitrogen they are attached to form a cycloamino ring); or R a and R b together with the nitrogen atom which they are attached to form a cycloamino ring. R c is hydrogen, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heteroaralkenyl, acyl, -CONR ' R " (where R ' and R" are independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl and heteroaralkyl, or R' and R" together with the nitrogen they are attached to form a cycloamino ring). R d is hydrogen, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heteroaralkenyl, acyl, -and additionally when n = 0, CONR ' R " (where R ' and R " are independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl and heteroaralkyl, or R' and R" together with the nitrogen they are attached to form a cycloamino ring) and when n = 2, NR'R" where R' and R" have the meanings given immediately above. Representative examples of heteroalkyl include, but are not limited to 2- methoxyethyl, benzyloxymethyl, thiophen-2-ylthiomethyl, and the like; " Cycloalkylalkyl " means a radical -R R b where R a is an alkylene group and R b is a cycloalkyl group as defined above e.g., cyclopropylmethyl, cyclohexylpropyl, 3-cyclohexyl-2-methylpropyl, and the like. " Aralkyl " means a radical -R R where R a is an alkylene group and R b is an aryl group as defined above e.g., benzyl, phenylethyl, 3-(3-chlorophenyl)-2- methylpentyl, and the like. " Aralkenyl " means a radical -R a R b where R a is an alkenyl group and R b is an aryl group as defined above e.g., 3-phenyl-2-propenyl, and the like. "Heteroaralkyl " means a radical -R a R b where R a is an alkylene group and R b is a heteroaryl group as defined above e.g., pyridin-3-ylmethyl, 3-(benzofuran-2- yl)propyl, and the like. "Heteroaralkenyl " means a radical -R a R b where R a is an alkenyl group and R b is a heteroaryl group as defined above e.g., 3-pyridin-3-ylpropen-2-yl, and the like. " Heterocycloalkyl " means a radical -R a R b where R a is an alkylene group and R b is a heterocyclo group as defined above e.g., tetrahydropyran-2-ylmethyl, 4- methylpiperazin-1-yl ethyl, and the like. " Alkoxy " , " aryloxy " , " heteroaryloxy " , " aralkyloxy " , or "heteroaralkyloxy" means a radical -OR where R is an alkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl respectively, as defined above e.g., methoxy, phenoxy, pyridin-2- yloxy, benzyloxy, and the like. "Optional" or "optionally" means that the subsequently described event or circumstance may but need not occur, and that the description includes instances where the event or circumstance occurs and instances in which it does not. For example, "heterocyclo group optionally mono- or di- substituted with an alkyl group " means that the alkyl may but need not be present, and the description includes situations where the heterocyclo group is mono- or disubstituted with an alkyl group and situations where the heterocyclo group is not substituted with the alkyl group. The term "protecting group" refers to a grouping of atoms that when attached to a reactive group in a molecule masks, reduces or prevents that reactivity. Examples of protecting groups can be found in T.W. Greene and P.G. Futs, Protective Groups in Organic Chemistry, (Wiley, 2nd ed. 1991) and Harrison and Harrison et al, Compendium of Synthetic Organic Methods, Vols. 1-8 (John Wiley and Sons. 1971-1996). Representative amino protecting groups include formyl, acetyl, trifluoroacetyl, benzyl, benzyloxycarbonyl (CBZ), tert-butoxycarbonyl (Boc), trimethyl silyl (TMS), 2-trimethylsilyl-ethanesulfonyl (SES), trityl and substituted trityl groups, allyloxycarbonyl, 9-fluorenylmethyloxycarbonyl (FMOC), nitro- veratryloxycarbonyl (NVOC) and the like. Representative hydroxy protecting groups include those where the hydroxy group is either acylated or alkylated such as benzyl and trityl ethers as well as alkyl ethers, tetrahydropyranyl ethers, trialkylsilyl ethers and allyl ethers. The term "protected hydroxylamine derivative" refers to a modified hydroxylamine whose nitrogen and/or hydroxyl groups are protected such that the nitrogen atom may be selectively monoacylated. Compounds that have the same molecular formula but differ in the nature or sequence of bonding of their atoms or the arrangement of their atoms in space are termed "isomers". Isomers that differ in the arrangement of their atoms in space are termed "stereoisomers". Stereoisomers that are not mirror images of one another are termed "diastereomers" and those that are non-superimposable mirror images of each other are termed "enantiomers". When a compound has an asymmetric center, for example, it is bonded to four different groups, a pair of enantiomers is possible. An enantiomer can be characterized by the absolute configuration of its asymmetric center and is described by the R- and S-sequencing rules of Cahn and Prelog, or by the manner in which the molecule rotates the plane of polarized light and designated as dextrorotatory or levorotatory (i.e., as (+) or (-)-isomers respectively). A chiral compound can exist as either individual enantiomer or as a mixture thereof. A mixture containing equal proportions of the enantiomers is called a "racemic mixture". The compounds of this invention may possess one or more asymmetric centers; such compounds can therefore be produced as individual (R)- or (S)- stereoisomers or as mixtures thereof. For example, if the R 1 and R 2 substituents in a compound of formula (I) are different, then the carbon to which they are attached is an asymmetric center and therefore the compound of formula (I) can exist as an (R)- or (S)-stereoisomer. Unless indicated otherwise, the description or naming of a particular compound in the specification and claims is intended to include both individual enantiomers and mixtures, racemic or otherwise, thereof. The methods for the determination of stereochemistry and the separation of stereoisomers are well- known in the art (see discussion in Chapter 4 of "Advanced Organic Chemistry", 4th edition J. March, John Wiley and Sons, New York, 1992). A "pharmaceutically acceptable excipient" means an excipient that is useful in preparing a pharmaceutical composition that is generally safe, non-toxic and neither biologically nor otherwise undesirable, and includes an excipient that is acceptable for veterinary use as well as human pharmaceutical use. A "pharmaceutically acceptable excipient" as used in the specification and claims includes both one and more than one such excipient. A "pharmaceutically acceptable salt" of a compound means a salt that is pharmaceutically acceptable and that possesses the desired pharmacological activity of the parent compound. Such salts include: (1) acid addition salts, formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like; or formed with organic acids such as acetic acid, propionic acid, hexanoic acid, cyclopentanepropionic acid, glycolic acid, pyruvic acid, lactic acid, malonic acid, succinic acid, malic acid, maleic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, 3-(4-hydroxybenzoyl)benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, 1,2-ethane-disulfonic acid, 2-hydroxyethanesulfonic acid, benzenesulfonic acid, 4-chlorobenzenesulfonic acid, 2-napthalenesulfonic acid, 4-toluenesulfonic acid, camphorsulfonic acid, 4-methylbicyclo[2.2.2]-oct-2-ene-l-carboxylic acid, glucoheptonic acid, 4,4'-methylenebis- (3-hydroxy-2-ene-l -carboxylic acid), 3-phenylpropionic acid, trimethylacetic acid, tertiary butylacetic acid, lauryl sulfuric acid, gluconic acid, glutamic acid, hydroxynapthoic acid, salicylic acid, stearic acid, muconic acid, and the like; or (2) salts formed when an acidic proton present in the parent compound either is replaced by a metal ion, e.g., an alkali metal ion, an alkaline earth ion, or an aluminum ion; or coordinates with an organic base such as ethanolamine, diethanolamine, triethanolamine, tromethamine, N-methylglucamine, and the like. "Pro-drugs" means any compound which releases an active parent drug according to Formula (I) in vivo when such prodrug is administered to a mammalian subject. Prodrugs of a compound of Formula (I) are prepared by modifying functional groups present in the compound of Formula (I) in such a way that the modifications may be cleaved in vivo to release the parent compound. Prodrugs include compounds of Formula (I) wherein a hydroxy, amino, or sulfhydryl group in a compound of Formula (I) is bonded to any group that may be cleaved in vivo to regenerate the free hydroxyl, amino, or sulfhydryl group, respectively. Examples of prodrugs include, but are not limited to esters (e.g., acetate, formate, and benzoate derivatives), carbamates (e.g., N,N-dimethylaminocarbonyl) of hydroxy functional groups in compounds of Formula (I), and the like. "Treating" or "treatment" of a disease includes: (1) preventing the disease, i.e. causing the clinical symptoms of the disease not to develop in a mammal that may be exposed to or predisposed to the disease but does not yet experience or display symptoms of the disease, (2) inhibiting the disease, i.e., arresting or reducing the development of the disease or its clinical symptoms, or (3) relieving the disease, i.e., causing regression of the disease or its clinical symptoms. A "therapeutically effective amount" means the amount of a compound that, when administered to a mammal for treating a disease, is sufficient to effect such treatment for the disease. The "therapeutically effective amount" will vary depending on the compound, the disease and its severity and the age, weight, etc., of the mammal to be treated. Compounds of this invention may be conveniently named with reference to their amino acid components in accordance with nomenclature conventional tothe peptide field. For example a dipeptide where n is 0, R 1 = R 3 = R 4 = R 6 = H, R 2 is 4- thiazolylmethyl, R 5 is (S,S)-l-methylpropyl and ZR 7 is benzyl oxycarbonyl, is named as CBz-Ile-4-Taz-NHOH. With respect to the synthetic schemes A and B subsequently presented, 4-Taz (4-thiazolylalanine) represents AAi and He represents AA 2 . A tripeptide where n is 1 and m is 0, R 1 = R 3 = R 4 = R 6 = R 9 = H, R 2 is 4- thiazolylmethyl, R 5 is (S,S)-l-methylpropyl, ZR 7 is 4-chlorobenzoyl and R 10 is 4- fluorobenzyl is named 4-chlorobenzoyl-(4-fluorobenzyl)Gly-Ile-Taz-NHOH. With respect to the synthetic schemes A and B subsequently presented, 4-Taz represents AAi, He represents AA 2 and (4-fluorobenzyl)Gly represents AA 3 . While the broadest definition of this invention is set forth in the first aspect of the present invention, certain compounds of formula (I) are preferred. One class of compounds are the dipeptidic hydroxamic acids corresponding to compounds of Formula 1 where n is 0. Another class of compounds are the tripeptidic hydroxamic acids corresponding to compounds of Formula 1 where n is 1. For both the dipeptidic and tripeptidic hydroxamic acid compounds of the invention, particularly preferred are those where R 2 is heteroaralkyl, particularly 4- thiazolylmethyl and R 5 is (S,S)-l-methylpropyl. Preferably, R 2 , R 5 and R 9 are present in the naturally ocurring amino acid configuration, i.e. derived from the (L) amino acids. Another class of preferred compounds of Formula I is that where Z is C(O)O. Another class of preferred compounds of Formula I is that where Z is S(O) 2 . Within each of these classes of compounds, more preferred are those where R 7 is aryl, aralkyl or heteroaryl, particularly halophenyl (e.g. 3,4-dibromophenyl, 2,5- dichlorophenyl or 2,4,5-trichlorophenyl), benzyl (optionally substituted) (e.g. benzyl or 3,4-dichlorobenzyl) or halothienyl (e.g. 4,5-dibromothien-2-yl). When Z is C=O, also preferred are R 7 being aralkyl or heteroaralkyl, particularly benzyl or heteroarylmethyl substituted with halo, preferably one or two chloro. Another class of preferred compounds is that where R 2 is aralkyl or heteroaralkyl. Within this class, more preferred are those compounds where R 2 is 3- indolyl methyl, 2-thienylmethyl, 4-imidazolylmethyl or 4-thiazolylmethyl, particularly 4-thiazolylmethyl. Another class of preferred compounds are those where R 2 is (alkylene)-B-X where B is -O-, -NR 8 -, -S-, -C=O, -CONR 8 -, -NR 8 CO 2 -, -NR 8 SO 2 - or - C(=NR 8 )NR 8 SO 2 -(where R 8 is independently H or alkyl), and X is cycloalkyl, cycloalkylalkyl, aryl, aralkyl heteroaryl or heteroaralkyl. Particularly preferred are compounds where the alkylene group is methylene, B is -NR 8 CO 2 and X is aralkyl. A fourth class of preferred compounds are those where R 5 is alkyl or phenyl, particularly propyl, 1-methylethyl, or (S,S)-l-methylpropyl. Within this class of compounds, particularly preferred are those where R 1 and R 4 are hydrogen and R 2 is heteroaralkyl, particularly 4-thiazolylmethyl. Furthermore preferred compounds are those of group B, namely compounds of formula I as defined in the first aspect of the present invention wherein n is 0, or (1) the compound of B wherein R 3 and R 6 are hydrogen. (2) the compound of (1), wherein: R 2 is aralkyl or heteroaralkyl. (3) the compound of (2) wherein: Z is -C(O)O- or -S(O) 2 -. (4) the compound of (3) wherein: R 2 is optionally substituted benzyl or heteroaralkyl. (5) the compound of (4) wherein, R 2 is 4-t-butoxybenzyl, 3-chlorobenzyl, 3- indolyl methyl, 2-thienylmethyl, 4-imidazolylmethyl or 4-thiazolylmethyl. (6) the compound of (5) wherein R 2 is 4-thiazolylmethyl. (7) the compound of (6) wherein: R 7 is aryl, aralkyl, heteroaryl or heteroaralkyl. (8) the compound of (6) wherein: Z is -C(O)O- and R 7 is optionally substituted benzyl. (9) the compound of (7) wherein: Z is -SO 2 - and R 7 is aryl or heteroaryl. (10) the compound of (8) or (9), wherein: R 1 and R 4 are hydrogen and R 5 is alkyl. (11) the compound of (10) wherein R 5 is (S,S)-l-methylpropyl. (12) The compound of (1), wherein: R 2 is (alkylene)-B-X where B is -O-, -NR 8 -, -S(O)„- (where n is 0, 1 or 2), - C=O, -CONR 8 -, -NR 8 CO 2 -, -NR 8 SO 2 - or -C(=NR 8 )NSO 2 -(where R 8 is H or alkyl), and X is cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl. (13) The compound of (12), wherein: Z is -C(O)O- or -S(O) 2 -. (14) The compound of (13), wherein R 2 is -CH 2 -B-X and B is -NHCO2- and X is benzyl. (15) The compound of (14) wherein: R 7 is aryl or aralkyl. (16) The compound of (15), wherein: R 1 and R 4 are hydrogen and R 5 is alkyl. (17) The compound of (16) wherein R 5 is (S,S)-l-methylpropyl. Furthermore preferred compounds are these of group C, namely compounds of formula I as defined in the first aspect of the present invention wherein n is 1. (1) The compound of C wherein m is 0 and R and R are hydrogen. (2) The compound of (1), wherein: R 2 is aralkyl or heteroaralkyl. (3) The compound of (2), wherein: Z is -C(O)O- or -S(O) 2 -. (4) The compound of (3), wherein: R 2 is optionally substituted benzyl or heteroaralkyl. (5) The compound of (4) wherein R is 4-t-butoxybenzyl, 3-chlorobenzyl, 3-indolyl methyl, 2-thienylmethyl, 4-imidazolylmethyl or 4-thiazolylmethyl. (6) The compound of (5) wherein R is 4-thiazolylmethyl. (7) The compound of (6) wherein: R »7 i •s aryl, aralkyl, heteroaryl or heteroaralkyl. (8) The compound of (7) wherein: Z is -C(O)O- and R 7 is benzyl. (9) The compound of (7) wherein: Z is -SO 2 - and R 7 is aryl. (10) The compound of (8) or (9), wherein: R 1 and R 4 are hydrogen and R 5 is alkyl. (11) The compound of (10) wherein R 5 is (S,S)-l-methylpropyl. (12) The compound of (1), wherein: R 2 is (alkylene)-B-X where B is -O-, -NR 8 -, -S-, -C=O, -CONR 8 -, -NR 8 CO 2 -, -NSO 2 - or -C(=NR 8 )NSO 2 -(where R 8 is H or alkyl), and X is cycloalkyl, cycloalkylalkyl, aryl, aralkyl heteroaryl or heteroaralkyl. (13) The compound of (12), wherein: Z is -C(O)O- or -S(O) 2 -. (14) The compound of (13), wherein R 2 is CH 2 -B-X and B is -NHCO 2 - and X is benzyl. (15) The compound of (14) wherein: R 7 is aryl or aralkyl. (16) The compound of (15), wherein: R 1 and R 4 are hydrogen and R 5 is alkyl. (17) The compound of (16) wherein R 5 is (S,S)-l-methylpropyl. Representative compounds of this invention that have been prepared according to the Schemes and Examples are as follows: I. Dipeptidic hydroxamic acids of Formula (I) where n = 0, R 1 = R 3 = R 4 =R 6 = hydrogen and ZR >7 i •s benzyloxycarbonyl and other groups are as defined below are: TABLE I ? St* - Stereochemistry at carbon attached to R" and of R " substituent (if it has an independent chiral centre) St** - Stereochemistry at carbon attached to R 5 and of R 5 susbstituent (if it has an independent chiral centre) π. Dipeptidic hydroxamic acids of Formula (I) where n = 0, R 1 = R 3 = R 4 = R 6 = hydrogen and R 4 is (S,S)- 1-methylpropyl and other groups are as defined below are: TABLE H St* Stereochemistry at carbon attached to R" πj. Dipeptidic hydroxamic acids of Formula (I) where n = 0, R 1 = R J = R 6 = hydrogen and ZR 7 is benzyloxycarbonyl and other groups are as defined below are: TABLE IJJ St* - Stereochemistry at carbon attached to R" IV. Dipeptidic hydroxamic acids of Formula (I) where n = 0, R 1 = R 3 = R 4 = hydrogen, R 2 is (S) 3-indolylmethyl and ZR 7 is benzyloxycarbonyl and other groups are as defined below are: TABLE IN St* - Stereochemistry at carbon attached to R 5 V. Tripeptidic hydroxamic acids of Formula I where n = 1, m = 0, R 1 = R J = R 4 = R 6 = H, R 2 is (S) 4-thiazolylmethyl, R 5 is (S,S)-l-methylpropyl and other groups are as defined below are: TABLE V St* - Stereochemistry at carbon attached to R 9 and of R 9 substituent (if it has an independent chiral centre) VI. Miscellaneous tripeptidic hydroxamic acid compounds of the invention where n = 1, m = 1, R 1 = R 3 = R 4 = R 6 = H, R 2 is (S)-4-thiazolylmethyl and R 5 is (S,S)-1- methylpropyl, and other groups are as defined below are include: TABLE VI Other miscellaneous compounds with R 2 and R 3 forming an alkylene or heteroalkylene chain include CBz-ϋe-Pro-NHOH (m/e = 378) and CBz-De-Thz-NHOH (m/e = 396). Thz is thiazolidine-4-carboxylic acid. Other miscellaneous compounds with R 5 and R 6 forming an alkylene chain include CBz-Pro-Trp-NHOH (m/e = 451). Compounds of this invention may be made by several synthetic methods as described below. The starting materials and reagents used in preparing these compounds are either available from commercial suppliers such as Aldrich Chemical Co., (Milwaukee, Wisconsin, USA), Bachem (Torrance, California, USA), Emka-Chemie, or Sigma (St. Louis, Missouri, USA) or are prepared by methods known to those skilled in the art following procedures set forth in references such as Fieser and Fieser's Reagents for Organic Synthesis, Volumes 1-15 (John Wiley and Sons, 1991); Rodd's Chemistry of Carbon Compounds, Volumes 1-5 and Supplemental (Elsevier Science Publishers, 1989), Organic Reactions, Volumes 1-40 (John Wiley and Sons, 1991), March's Advanced Organic Chemistry, (John Wiley and Sons, 4th Edition), and Larock's Comprehensive Organic Transformations (VCH Publishers Inc., 1989). In particular, a variety of natural and unnatural amino acids in various protected forms are available from specialty chemical suppliers such as Novabiochem Inc. (La Jolla, CA), Advanced Chemtech Inc. (Louisville, KY), Synthetech Inc. (Albany, OR), Bachem Inc. (Torrance, CA). These schemes are merely illustrative of some methods by which the compounds of this invention can be synthesized, and various modifications to these schemes can be made and will be suggested to one skilled in the art having referred to this disclosure. The starting materials and the intermediates of the reaction may be isolated and purified if desired using conventional techniques, including but not limited to filtration, distillation, crystallization, chromatography, and the like. The compounds of the invention are C-terminal hydroxamic derivatives of natural and unnatural di- and tripeptides further functionalized at the N-terminus. They may be made by initially assembling the peptide precursor followed by deprotection (as necessary) and functionalization of the C- and N-termini. The peptide precursors are made by methods known to those of skill in the art of peptide synthesis, including solution phase chemistries and solid phase synthesis, see Solid Phase Peptide Synthesis: A Practical Approach by E. Atherton and R.C. Sheppard (Oxford University Press, 1989) In general, as shown in Schemes A and B, a C-terminal protected amino acid Pi-AAi is coupled to an N-protected amino acid AA 2 -P to give a compound P 1 -AA 1 - AA 2 -P 2 . Coupling is accomplished by activating the C-terminus of AA2-P2 and condensation with the amine of P 1 -AA 1 . Activating reagents and coupling conditions are well known to one of skill in the art and include carbodiimide mediated coupling or formation of N-hydroxysuccinimide esters followed by acylation. For synthesis of the dipeptidic hydroxamic acids, protecting group removal and N-terminal functionalization with R -Z-L (in either order) is effected to give a dipeptide precursor that is converted to a hydroxamic compound of the invention, typically by treatment with hydroxylamine. For synthesis of the tripeptidic hydroxamic acids, compound Pi- AA]-AA 2 -P 2 is selectively N-deprotected to give P 1 -AA 1 -AA 2 which is then coupled to an N-protected amino acid AA 3 -P 3 . Deprotection, N-terminal functionalization and treatment with hydroxylamine as shown in Scheme B then gives tripeptide hydroxamic acids of Formula I. Scheme A Synthesis of dipeptidic hydroxamic acids 1) activation deprotection >_- P 1 -AA,-AA 2 -P »► P r AA r AA 2 P r AA j 7 NH 2 OH , HONH-AA r AA 2 -Z-R 7 -« ≤ P r AA,-AA 2 -Z-R 7 Formula I where n=0 Scheme B Synthesis of tripeptidic hydroxamic acids ^^3 " P3 deprotection P r AA r AA 2 ► P l -AA 1 -AΛ 2 -AA 3 -P 3 * coupling reagents 1) R 7 -Z-L P r AA r AA 2 -NA 3 HONH-AA r AA 2 -AA 3 -Z-R 7 2) ΝH 2 OH Formula I where n=l With reference to the nomenclature in Formula I, AAi corresponds to -C(=O)- CR'R 2 -NR 3 -, AA 2 corresponds to -C(=O)-CR 4 R 5 -NR 6 and AA 3 corresponds to -C(=O)- CH(R 9 )-(CH 2 ) m -NR 10 . P ls P 2 and P 3 represent protecting groups. In particular, compounds of this invention may be prepared by solid phase synthesis. Initially, an N-protected amino acid PpAAi is attached to a solid phase resin via its C-terminus. Typical solid phase resins include chloromethylated and hydroxymethylated resins such as the 4-hydroxymethyl-phenylacetamidomethyl resin (Pam resin) and the 4-benzyloxybenzyl alcohol resin (Wang resin) available from Advanced Chemtech, Louisville, Kentucky, U.S.A. and the pegylated polystyrene resin, ArgoGel-OH™, resin from Argonaut Technologies Inc. (Belmont, CA). Preferred chloromethyl resins include the styrene/divinylbenzene resins known as Merrifield resins available from Aldrich Chemical Company, Milawaukee, Wisconsin, U.S.A. Amino acid building blocks, AA 2 and AA 3 are then attached sequentially using iterative coupling and deprotection steps well known to one of skill in the art. Coupling reactions are done under conventional peptide coupling conditions, typically in an anhydrous inert aprotic polar solvent (e.g. dimethyl formamide, acetonitrile, tetrahydrofuran, dichloromethane etc.) using auxiliary coupling reagents, e.g., carbodiimides such as l-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDAC), diisopropylcarbodiimide (DIC), diimidazoles such as carbonyldiimidazole, triazoles such as hydroxybenzotriazole (HOBT) or other carboxyl activating groups such as N- hydroxysuccinimide, in the presence of an tertiary organic base such 4- dimethylaminopyridine, N-methylmorpholine or triethylamine. The protecting groups employed depend on the group being protected and are also known to those of skill in the art. Representative protecting groups may be found in Protective Groups in Organic Chemistry. J.F.W. McOmie (London, Plenum Press, (1973)) and Protective Groups in Organic Chemistry, T.W. Greene and P.G. Wuts (John Wiley and Sons, (1991)). A favoured N-protecting group is the fluorenylmethoxycarbonyl (FMOC) group. After assembly of the entire peptide skeleton, the protecting group at the N- terminus is removed. In certain cases the N-terminal protecting group may correspond to ZR 7 , obviating the need for protecting group removal. Functionalization at the N- terminus is effected by subsequent treatment with a compound R 7 -Z-L, where L is a leaving group under nucleophilic displacement conditions. The conditions used for protecting group removal vary depending on the protecting group. Acid sensitive protecting groups such as tert-butoxycarbonyl (t-BOC) are removed with mild acid (e.g trifluoroacetic acid) whereas base sensitive protecting groups such as 9- fluorenylmethoxycarbonyl (FMOC) are removed with mild organic base. Typical leaving groups L include halo, tosylate and mesylate. Finally cleavage off the solid phase is accomplished by treatment with hydroxylamine to give compounds of Formula I. As stated above, both natural and unnatural amino acids may be used in preparing the compounds of this invention. The natural amino acids and their abbreviations are well known and will not be repeated here. Some examples of unnatural amino acids and their abbreviations include, homoserine (hSer), homoserine lactone (hSerlac), homocysteine (Hey), homoarginine (hArg), homocitrulline (Hci), penicillamine (Pen), Nα-methylarginine (N-MeArg), norleucine (Nle), norvaline (Nval), norisoleucine (Nile), N-methylisoleucine (N- Melle), phenylglycine (PhG), t-butylglycine (Tie), hydroxyproline (Hyp), 3,4- dehydroproline (Δ-Pro), pyroglutamine (Pyr,Glp), ornithine (Orn), 2,3- diaminopropionic acid (2,3-DAP), 1-aminoisobutyric acid (1-Aib), 2- aminoisobutyric acid (2-Aib), 2-aminobutyric acid (2-Abu), 4-aminobutyric acid (4- Abu), 2,4-diaminobutyric acid (A2bu), α-aminosuberic acid (Asu), albizzin (Abz), β-cyclohexylalanine (Cha), 3-(l-naphthyl)alanine (1-Nal), 3-(2-naphthyl)alanine (2- Nal), citrulline (Cit). pipecolinic acid (Pip), 4-chlorophenylalanine (4-ClPhe), 4- fluorophenylalanine (4-FPhe), sarcosine (Sar), 4-thiazolylalanine (4-Taz), homophenylalanine (Hpa or hPhe), 2-thienylalanine (2-Thi), 3-benzothienylalanine (3-Bal), and 1-aminopropanecarboxylic acid (1-NCPC). A variety of unnatural amino acids are available from commercial vendors. Compounds of this invention are useful to treat diseases associated with the excessive deposition of interstitial collagens, such as fibroproliferatives diseases exemplified by interstitial pulmonary fibrosis, pericentral fibrosis, Symmers' fibrosis, perimuscular fibrosis, kidney fibrosis, endocardial sclerosis, hepatitis, acute respiratory distress syndrome, arthritis, cystic fibrosis, surgical adhesions, tendon surgery, corneal scarring, scleroderma, chronic allograft rejection, hemodialysis shunt fibrosis and restenosis. Compounds of this invention are inhibitors of procollagen C-proteinase and thereby inhibit the C-terminal processing of types I, II and HI collagens necessary for their ability to form insoluble collagen fibrils. Furthermore, selected compounds of the invention selectively inhibit procollagen C-proteinase over other collagen degrading enzymes such as collagenase-1, collagenase-2 and collagenase-3. As a result, compounds of this invention leave largely unaffected the natural resorption of collagen mediated by collagenase-1, collagenase-2 and collagenase-3. Due to this selectivity, such compounds are of greater therapeutic efficacy than nonselective inhibitors. In particular, preferred compounds of this invention inhibit procollagen C-proteinase with greater than 100 fold selectivity over collagenase-1 and collagenase-2 and the most selective compounds are more than a thousand fold more selective. Selective inhibition of procollagen C-proteinase over collagenase-1 and collagenase-2 was demonstrated by the assays described in the Examples. Thereby, this invention allows the treatment of fibrotic diseases by administering to a patient an agent that selectively inhibits procollagen C-proteinase over collagenase-1, collagenase-2 and collagenase-3. The inhibition may be 10 fold more selective, preferably 100 fold more selective and most preferably 1000 fold more selective. The ability of the compounds of Formula (I) to inhibit procollagen C- proteinase activity, may be demonstrated by a variety of in vitro assays known to those of ordinary skill in the art, such as the assay described in more detail in Example XHI. The selectivity against collagenase enzymes may be determined by testing as described in Example XTV. The in vivo efficacy of compounds of Formula (I) against fibrotic disease and the overproduction and deposition of collagen may be shown by numerous animal models including the mouse bleomycin induced pulmonary fibrosis model (S.H. Phan et.al. "Bleomycin-induced Pulmonary Fibrosis," Am. Rev. Respir. Pis., 124:428-434 (1981) and P.F. Piguet et al. "Effective Treatment of the Pulmonary Fibrosis Elicited in Mice by Bleomycin or Silica with anti-CD- 11 Antibodies," Am. Rev. Resp. Pis.. 147:435-441 (1993)) the sponge implant model (E.N. Unemori et al. "Human Relaxin Decreases Collagen Accumulation In Vivo in Two Rodent Models of Fibrosis," J. Invest. DermatoL. 101:280-285 (1993), the carbon tetrachloride or NDMU induced renal fibrosis model, as well as other animal models cited in WO 97/05865 ("C-Proteinase Inhibitors for the Treatment of Disorders Relating to the Overproduction of Collagen"). In general, the compounds of this invention will be administered in a therapeutically effective amount by any of the accepted modes of administration for agents that serve similar utilities. The actual amount of the compound of this invention, i.e., the active ingredient, will depend upon numerous factors such as the severity of the disease to be treated, the age and relative health of the subject, the potency of the compound used, the route and form of administration, and other factors. The drug can be administered more than once a day, preferably once or twice a day. Therapeutically effective amounts of compounds of formula I may range from approximately 0.05-35 mg per kilogram body weight of the recipient per day; preferably about 0.3-20 mg/kg/day. Thus, for administration to a 70 kg person, the dosage range would most preferably be about 21 mg to 1.4 g per day. In general, compounds of this invention will be administered as pharmaceutical compositions by any one of the following routes: oral, systemic (e.g., transdermal, intranasal, pulmonary or by suppository), or parenteral (e.g., intramuscular, intravenous or subcutaneous) administration. The preferred manner of administration is systemic using a convenient daily dosage regimen which can be adjusted according to the degree of affliction. Intranasal delivery is typically accomplished with dry powder formulations, liquid solutions or suspensions suitable for nebulization or with aerosol propellants suitable for use in a metered dose inhaler. Alternatively, drug substance may be associated with microspheres made of materials such as gelatin, dextran, collagen or albumin The microspheres are conveniently delivered in freeze dried form with a nasal insufflator device or a pressurized aerosol cannister. Penetration enhancers such as amphiphilic steroids may also be used as additives to increase the systemic absorption of the drug into the tissue. Effective administration may also be accomplished by pulmonary or respiratory delivery since polypeptides are readily absorbed through the cellular lining of the alveolar region of the mammalian lung. Advantageously, such administration frequently does not require the use of penetration enhancers as additives. Devices and methods for pulmonary delivery deep into the lung are described in U.S. Patent No. 5,780,014 and U.S. Patent No. 5,814,607. Lastly, compounds may be systemically administered by transdermal delivery, which typically involves placing the drug on the surface of the skin and allowing it to permeate through the skin. Transdermal delivery devices employ a structure such as an adhesive patch or the like that serves as a reservoir for the drug and brings the drug into diffusive contact with the skin. In one general typ, the structure is a three dimensionally stable matrix known as a monolithic matrix. Such matrices are described in more detail in U.S. Patent Nos. 5,804,214, 5,149,538 and 4,956,171 which describe matrices made of polymers and copolymers of acrylic latexes, acrylic esters, methacrylic esters and vinyl acetates. The choice of formulation depends on various factors such as the mode of drug administration (e.g., for oral administration, formulations in the form of tablets, pills or capsules are preferred) and the bioavailability of the drug substance. Recently, pharmaceutical formulations have been developed especially for drugs that show poor bioavailability based upon the principle that bioavailability can be increased by increasing the surface area i.e., decreasing particle size. For example, U.S. Pat. No. 4,107,288 describes a pharmaceutical formulation having particles in the size range from 10 to 1,000 nm in which the active material is supported on a crosslinked matrix of macromolecules. U.S. Pat. No. 5,145,684 describes the production of a pharmaceutical formulation in which the drug substance is pulverized to nanoparticles (average particle size of 400 nm) in the presence of a surface modifier and then dispersed in a liquid medium to give a pharmaceutical formulation that exhibits remarkably high bioavailability. The compositions are comprised of in general, a compound of formula (I) in combination with at least one pharmaceutically acceptable excipient. Acceptable excipients are non-toxic, aide administration, and do not adversely affect the therapeutic benefit of the compound of formula (I). Such excipient may be any solid, liquid, semi-solid or, in the case of an aerosol composition, gaseous excipient that is generally available to one of skill in the art . Solid pharmaceutical excipients include starch, cellulose, talc, glucose, lactose, sucrose, gelatin, malt, rice, flour, chalk, silica gel, magnesium stearate, sodium stearate, glycerol monostearate, sodium chloride, dried skim milk and the like. Liquid and semisolid excipients may be selected from glycerol, propylene glycol, water, ethanol and various oils, including those of petroleum, animal, vegetable or synthetic origin, e.g., peanut oil, soybean oil, mineral oil, sesame oil, etc. Preferred liquid carriers, particularly for injectable solutions, include water, saline, aqueous dextrose, and glycols. Compressed gases may be used to disperse a compound of this invention in aerosol form. Inert gases suitable for this purpose are nitrogen, carbon dioxide, etc. Other suitable pharmaceutical excipients and their formulations are described in Remington 's Pharmaceutical Sciences, edited by E. W. Martin (Mack Publishing Company, 18th ed., 1990). The amount of the compound in a formulation can vary within the full range employed by those skilled in the art. Typically, the formulation will contain, on a weight percent (wt%) basis, from about 0.01-99.99 wt% of a compound of formula I based on the total formulation, with the balance being one or more suitable pharmaceutical excipients. Preferably, the compound is present at a level of about 1- 80 wt%. Representative pharmaceutical formulations containing a compound of formula I are described in Example 30. EXAMPLES Ac2θ capping solution - 19 mL AC2O, 9 mL DIPEA, 0.8 eq. HOBt, 400 mL NMP Abbreviations Ac 2 O - acetic anhydride DIPEA - diisopropylethylamine HOBt - hydroxybenzotriazole NMP - N-Methylpyrrolidinone FMOC - Fluorenylmethoxycarbonyl BOC - t-butoxycarbonyl DIC - diisopropylcarbodiimide DMAP - 4-dimethylaminopyridine HATU - O-(7-azabenzotriazol-l-yl)-l,l,3,3-tetramethyluronium hexafluorophosphate] HO AT - l-hydroxy-7-azabenzotriazole TFA - trifluoroacetic acid DMF - dimethylformamide TIS - triisopropylsilane CBz - benzyloxycarbonyl THF - tetrahydrofuran Taz - 4-thiazolylalanine He - isoleucine Su - succinimidyl TEA - triethylamine Tip - tryptophan DMSO - dimethylsulfoxide TMS - trimethylsilyl DMEM-HG - Dulbeccos Modified Eagle Medium, high glucose G418 - Geniticin SYNTHESIS OF COMPOUNDS OF FORMULA I Compounds of Formula (I) were made by solid phase synthesis using conventional methods as generally described in the following Examples. If necessary, the compounds prepared as described in Examples I-X were purified by reverse phase high pressure liquid chromatography on silica gel bonded diisopropylphenethylsilane columnns (Zorbax SB-Phenyl) using gradient elution with a mixed acetonitrile-water (1% TFA) solvent system at flow rates of approximately 1.5- 2.0 mlJminute. They were directly tested in the PCP and collagenase assays described in Examples XHI and XIV without further purification. The compounds may be characterized using conventional means, including physical constants and spectral data. In particular, they were analyzed by mass spectrometry using electron spray ionization. Example I General Experimental for CBz-AA2-AAj-NHOH (Dipeptide Compounds of Formula I where ZR 7 is benzyloxycarbonyl) To ArgoGel-OH™ (Argonaut Technologies, Belmont, CA) in a empty solid phase extraction vial, fitted with a stopcock was added 3 eq. of either BOC or FMOC protected AAj, 3 eq. of diisopropylcarbodiimide and 0.05 eq. of a 0.116 M solution of dimethylaminopyridine in THF. Sufficient CH2CI2 was added to swell the resin (-12.5 mL/gr of resin). [Alternatively, to the resin was added 3 eq. of either BOC or FMOC protected AAi, 3 eq. of HATU, 3 eq. HO At and 6 eq. of DIPEA. Sufficient NMP was added to swell the resin (-12.5 mlJgr of resin ).] The reaction was then placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, once with 1:1 HOAC/CH2CI2, three times with MeOH and then lastly three times with CH2CI2 and dried to give BOC-AA^-resin or FMOC-AAi resin. The unreacted resin sites were then capped off with an AC2O capping solution (19 mL AC2O, 9 mL DIPEA, 0.8 gr HOBt, 400 mL NMP) in a sufficient quantity added to swell the resin (-12.5 mlJgr of resin). The resin was then filtered and washed as above. 2. H2N-AAι -resin 2a. For BOC protected material - The resulting resin from above (BOC-AA \- resin) was treated with a solution of 95/2.5/2.5 TFA/H2θ/triisopropyl silane (TIS) for two hours. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, and then three times with CH2CI2 to give H2N-AA1 -resin. 2b. For FMOC protected material - The resulting resin from above (FMOC-AA^- resin) was first washed with DMF then treated with a solution of 20% piperidine in DMF for 20 min. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, once with 1:1 HOAC CH2CI2, three times with MeOH and then lastly three times with CH2CI2, to give H2N-AA1 - resin. 3. CBZ-AAΪ-AAX resin To H2N-AA1 -resin was added 3 eq. of CBZ protected AA2, 3 eq. of diisopropylcarbodiimide and 0.05 eq. of a 0.116 M solution of dimethylaminopyridine in THF. Sufficient CH2CI2 was added to swell the resin (-12.5 mlJgr of resin). [Alternatively, to the resin was added 3 eq. of CBz protected AA2, 3 eq. of HATU, 3 eq. HO At and 6 eq. of DIPEA. Sufficient NMP is added to swell the resin (-12.5 mlJgr of resin ).] The reaction was then placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, once with 1: 1 HOAC CH2CI2, three times with MeOH and then lastly three times with CH2CI2 to give CBZ-AA2-AA1 -resin. 4. Removal of protecting groups If AAi or AA2 contains an acid labile side chain protecting group that is to be removed, the resulting resin (CBZ-AA2-AA1 -resin) was treated with a solution of 95/2.5/2.5 TFA/H2θ/triisopropyl silane (TIS) for 2 hours. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, and then three times with CH2CI2. 5. CBz-AA2-AAι-NHOH CBZ-AA2-AA1 -resin was first washed with THF. Sufficient THF was added to swell the resin (-12.5 mlJgr of resin) then 25 eq. of 50% aq. NH2OH was added and the reaction was rotated for two days. The reaction was then filtered by suction filtration and washed with CH2CI2, MeOH, and then CH2CI2. The filtrate was concentrated under vacuum to obtain CBz-AA2-AA^-NHOH. Example II General Experimental for R^SO^-AAo-AAj-NHOH (Dipeptide compounds of Formula I where Z is -SO 2 -) 1. FMOC-AA -AA^-resin To H2N-AAι-resin was added 3 eq. of FMOC protected AA2, 3 eq. of diisopropylcarbodiimide and 0.05 eq. of a 0.116 M solution of 4- dimethylaminopyridine in THF. Sufficient CH2CI2 was added to swell the resin (-12.5 mlJgr of resin). The reaction was then placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, once with 1 : 1 HOAC/CH2CI2, three times with MeOH and then lastly three times with CH2CI2, to give FMOC-AA2- AA1 -resin. 2. H N-AAo-AAj-resin FMOC-AA2-AA1 -resin was first washed with DMF then treated with a solution of 20% piperidine in DMF for 20 min. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, once with 1:1 HOAC/CH2CI2, 3 times with MeOH and then lastly 3 times with CH2CI2, to give H2N-AA2-AA1 -resin. 3. R^SOo-AAg-AAi-resin H2N-AA2-AA1 -resin was first washed with aq. dioxane, then 10 eq. of the desired sulfonyl chloride, R 7 -SO 2 Cl, was added. Sufficient 90% aq. dioxane was added to swell the resin (-12.5 mlJgr of resin). Then 20 eq. of diisopropylethylamine was added. The reaction was then placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, once with 1:1 HOAC/CH2CI2, three times with MeOH and then lastly three times with CH2CI2 to give R 7 -SO2- AA2-AA1 -resin. 4. R 7 -SO -AA2-AAi-NHOH R 7 -SO 2 -AA2-AAι -resin was first washed with THF. Sufficient THF was added to swell the resin (-12.5 mL/gr of resin) then 25 eq. of 50% aq. NH2OH was added and the reaction was rotated for two days. The reaction was then filtered by suction filtration and washed with CH2CI2, MeOH, and then CH2CI2. The filtrate was concentrated under vacuum to obtain R 7 -SO2-AA2~AAi-NHOH. Example HI General Experimental for R 7 NHCO-AA2-AAj_-NHOH (Dipeptide compounds of Formula I where Z is -CONH-) H2N-AA2-AA1 -resin was first washed with THF, then 3 eq. of the desired isocyanate, R N=C=O, was added. Sufficient THF was added to swell the resin (-12.5 mL/gr of resin). The reaction was then placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, once with 1 : 1 HOAC/CH2CI2, three times with MeOH and then lastly three times with CH2CI2 to give R 7 -NHCO-AA2- AA1 -resin. 2. Removal of protecting groups If AAi or AA2 contains an acid labile side chain protecting group that is to be removed, the resulting resin (R 7 -NHCO-AA2-AAι -resin) was treated with a solution of 95/2.5/2.5 TFA/H2θ/triisopropyl silane (TIS) for 2 hours. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, and then three times with CH2CI2. 3. R 7 -NHCO-AA2-AAι-NHOH R 7 NHCO-AA2-AAι -resin was first washed with THF. Sufficient THF was added to swell the resin (-12.5 mlJgr of resin) then 25 eq. of 50% aq. NH2OH was added and the reaction was rotated for two days. The reaction was then filtered by suction filtration and washed with CH2CI2, MeOH, and then CH2CI2. The filtrate was concentrated under vacuum to obtain R 7 NHCO-AA2-AAι-NHOH. The dipeptide hydroxamic acids in Table II and Table V where Z is -CONH- were prepared using the procedure of Example 3. Example IV General Experimental for R 7 -CO-AA2-AAι-NHOH (Dipeptide compounds of Formula I where Z is -CO-) 1. R 7 -CO-AA2-AAι-resin To H2N-AA2-AA1 -resin was added sufficient CH2CI2 to swell the resin (-12.5 mlJgr of resin). 3 eq. of the desired acid chloride, R 7 COCl, and 3 eq. of E-3N were then added. A second alternative was add to the CH 2 C1 2 swollen resin 3 eq. of the desired carboxylic acid, R 7 CO 2 H, 3 eq. of diisopropylcarbodiimide and 0.05 eq. of a 0.116 M solution of dimethylaminopyridine in THF. A third alternative was to swell the resin with sufficient CH3CN (-12.5 mlJgr of resin) and couple the desired acid chloride, R 7 COCl (3 eq.) in the presence of 6 eq. of trimethylsilylcyanide. In all cases the reaction was then placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, once with 1 : 1 HOAC/CH2CI2, three times with MeOH and then lastly three times with CH2CI2 to give R 7 -CO- AA2-AA1 -resin. 2. Removal of protecting groups If AAi or AA2 contains an acid labile side chain protecting group that is to be removed, the resulting resin (R 7 -CO-AA2-AAι -resin) was treated with a solution of 95/2.5/2.5 TFA/H2θ/triisopropyl silane (TIS) for 2 hours. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, and then three times with CH2CI2. R 7 -CO-AA2-AAi -resin was first washed with THF. Sufficient THF was added to swell the resin (-12.5 mL/gr of resin) then 25 eq. of 50% aq. NH2OH was added and the reaction was rotated for two days. The reaction was then filtered by suction filtration and washed with CH2CI2, MeOH, and then CH2CI2. The filtrate is concentrated under vacuum to obtain R 7 -CO-AA2-AAι-NHOH. Example V (Dipeptide compounds of Formula I where Z is -C(O)O-) 1. R 7 -OCO-AA2-AAι-resin. To H2N-AA2-AA1 -resin was added 3 eq. of the desired succinimidylcarbonate, R 7 OC(=O)NHS, 3 eq. Et3N and and 0.05 eq. of a 0.116 M solution of 4-dimethylaminopyridine in THF. Sufficient CH2CI2 was added to swell the resin (-12.5 mlJgr of resin). Another alternative was to add to the resin 10 eq. of the desired chloroformate, R 7 OCOCl, and 20 eq. diisopropylethylamine followed by sufficient 90% aq. dioxane to swell the resin (-12.5 mlJgr of resin)]. In either case, the reaction was then placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, once with 1: 1 HOAC/CH2CI2, three times with MeOH and lastly three times with CH2CI2 to give R 7 -OCO-AA2-AAι -resin. 2. Removal of protecting groups If AAj or AA2 contains an acid labile side chain protecting group that is to be removed, the resulting resin (R -OCO-AA2-AA1 -resin) was treated with a solution of 95/2.5/2.5 TFA H2θ/triisopropyl silane (TIS) for 2 hours. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, and then three times with CH2CI2. 3. R 7 -OCO-AA2-AAι-NHOH R 7 -OCO-AA2-AAι -resin was first washed with THF. Sufficient THF was added to swell the resin (-12.5 mlJgr of resin) and 25 eq. of 50% aq. NH2OH is added and the reaction was rotated for two days. The reaction was then filtered by suction filtration and washed with CH2CI2, MeOH, and then CH2CI2. The filtrate was concentrated under vacuum to obtain R 7 -OCO-AA2-AAι-NHOH. Example VI General experimental for CBz-NR 6 -CH ? CO-AA NHOH 1. BiCHgCO-AAj-resin To H2N-AAι-resin was added 12 eq. of bromoacetic acid and 13 eq. of diisopropylcarbodiimide. Sufficient CH2CI2 was added to swell the resin (-12.5 mlJgr of resin). The reaction was then placed on a spinner and rotated for 2 hrs. The reaction was filtered by suction filtration and washed three times with CH2CI2, three times with DMSO and lastly three times with CH2CI2 to give BrC^CO-AA^- resin. 2. R 6 -NHCH2CO-AAι-resin BrCH2CO-AAι -resin was first washed with DMSO. Sufficient DMSO was added to swell the resin (-12.5 mlJgr of resin) followed by the addition of 40 eq. of the desired primary amine, R 6 NH 2 . The reaction was then placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, once with 1:1 HOAC CH2CI2, three times with MeOH and then lastly three times with CH2CI2 to give R 6 - NHCH 2 CO-AAι -resin. To R 6 -NHCH2CO-AAι -resin is added 3 eq. of CBZOSu, 3 eq. Et3N and 0.05 eq. of a 0.116 M solution of 4-dimethylaminopyridine in THF. Sufficient CH2CI2 was added to swell the resin (-12.5 mlJgr of resin). The reaction was then placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, once with 1:1 HOAC/CH2CI2, three times with MeOH and lastly three times with CH2CI2 to give CBz-NR 6 -CH 2 CO-AAι -resin. 4. Removal of protecting groups If AAi or AA2 contains an acid labile side chain protecting group that is to be removed, the resulting resin (CBz-NR 6 -CH 2 CO-AAι -resin) was treated with a solution of 95/2.5/2.5 TFA H2O/ triisopropyl silane (TIS) for 2 hours. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, and then three times with CH2CI2. 5. CBz-NR 6 -CH9CO-AAι-NHOH CBz-NR 6 -CH 2 CO-AAι -resin was first washed with THF. Sufficient THF was added to swell the resin (-12.5 mlJgr of resin) and then 25 eq. of 50% aq. NH2OH was added and the reaction was rotated for two days. The reaction was then filtered by suction filtration and washed with CH2CI2, MeOH and finally CH2CI2. The filtrate was concentrated under vacuum to obtain CBz-NR 6 -CH 2 CO-AAι- NHOH. Example VII General experimental for R 7 NHCO-AA 2 -AAι-NHOH (Dipeptide Compounds of Formula I where Z is -C(O)NH-) 1. To ArOCO-AA 2 -AAι -resin (Ar = Ph) was added sufficient DMF to swell the resin (-12.5 mL gr of resin). 20 eq. of R 7 NH was added and the reaction reaction was then placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and washed three times with CH C1 2 , three times with MeOH, once with 1: 1 HOAc/CH 2 Cl 2 , three times with MeOH and then lastly three times with CH 2 C1 2 to give R 7 NHCO-AA 2 -AAι -resin. 2. R 7 NHCO-AA 2 -AA, -resin was first washed with THF. Sufficient THF was added to swell the resin (-12.5 mlJgr of resin), then 25 eq. of 50% aq. NH 2 OH was added and the reaction was rotated for two days. The reaction was then filtered by suction filtration and washed with CH 2 C1 2 , MeOH, and then CH 2 CI 2 . The filtrate was concentrated under to obtain R 7 NHCO-AA 2 -AAι-NHOH. Example VHI General experimental for CBz-AA 3 -AA -AA -NHOH (Tripeptide Compounds of Formula I where n = 1 and ZR is benzyloxycarbonyl) 1. CBz-AA 3 -AA 2 -AA 1 -resin To H 2 N-AA 2 -AAi -resin was added three eq. of CBZ protected AA 3 , three eq. of diisopropylcarbodiimide and 0.05 eq. of a 0.116 M solution of dimethylaminopyridine in THF. Sufficient CH Cl 2 is added to swell the resin (-12.5 mlJgr of resin). [An alternative is to add to the resin three eq. of CBz protected AA 3 , three eq. of HATU, three eq. HO At and six eq. of DIPEA. Sufficient NMP was added to swell the resin (-12.5 mlJgr of resin ).] The reaction wasplaced on a spinner and rotated overnight. The reaction was filtered by suction filtration and washed three times with CH 2 CI 2 , three times with MeOH, once with 1:1 HOAc/CH 2 Cl 2 , three times with MeOH and lastly three times with CH 2 C1 , to give CBz-AA 3 -AA 2 -AAι-resin. 2. Removal of protecting groups If AAi, AA 2 or AA 3 contains an acid labile side chain protecting group that is to be removed, the resulting resin (CBz-AA 3 -AA 2 -AAι-resin) was treated with a solution of 95/2.5/2.5 TFA H 2 O, triisopropyl silane (TIS) for 2 hours. The reaction was then filtered by suction filtration and washed three times with CH 2 C1 2 , three times with MeOH, and then three times with CH 2 CI 2 . 3. CBz-AA AA 2 -AA NHOH CBz-AA 3 -AA 2 -AA 1 -resin was first washed with THF. Sufficient THF was added to swell the resin (-12.5 mlJgr of resin) then 25 eq. of 50% aq. NH 2 OH was added and the reaction was rotated for two days. The reaction was filtered by suction filtration and washed with CH 2 C1 2 , MeOH, and finally with CH 2 C1 2 . The filtrate was concentrated under vacuum to obtain CBz-AA 3 -AA 2 -AA 1 -NHOH. Example DC General experimental for R 7 Z-AA -AA 2 -AA 1 -NHOH (Tripeptide Compounds of Formula I where Z is -SO 2 - or -C(O)NH-) To H 2 N-AA 2 -AAι -resin was added three eq. of FMOC protected AA 3 , three eq. of diisopropylcarbodiimide and 0.05 eq. of a 0.116 M solution of 4- dimethylaminopyridine in THF. Sufficient CH 2 C1 2 was added to swell the resin (-12.5 mlJgr of resin). [ and alternative was to add to the resin three eq. of FMOC protected AA 3 , three eq. of HATU, three eq. HO At and six eq. of DIPEA. Sufficient NMP was added to swell the resin (-12.5 mlJgr of resin ).] The reaction was placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and washed three times with CH 2 C1 2 , three times with MeOH, once with 1 : 1 HOAc/CH 2 Cl 2 , three times with MeOH and then lastly three times with CH 2 C1 2 to give FMOC-AA 3 -AA 2 -AAι -resin. 2. H 2 N-AA 3 -AA 2 -AAj_-resin FMOC-AA 3 -AA 2 -AAι -resin was first washed with DMF then treated with a solution of 20% piperidine in DMF for 20 min. The reaction was then filtered by suction filtration and washed three times with CH C1 2 , three times with MeOH, once with 1:1 HOAc/CH 2 Cl 2 , three times with MeOH and then lastly three times with CH 2 C1 2 to give H 2 N-AA 3 -AA2-AA! -resin. 3. R 7 Z-AA AA7-AA resin 3a. For Z = SO : H 2 N-AA 3 -AA 2 -AA] -resin is first washed with aq. dioxane, then 10 eq. of the desired sulfonyl chloride, R 7 SO 2 Cl, is added followed by sufficient 90% aq. dioxane to swell the resin (-12.5 mlJgr of resin). Then 20 eq. of diisopropylethylamine was added. The reaction was then placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and washed three times with CH 2 C1 2 , three times with MeOH, once with 1: 1 HOAc/CH 2 Cl 2 , three times with MeOH and then lastly three times with CH 2 C1 2 to give R 7 SO 2 -AA 3 - AA 2 -AAι-resin. 3b. For Z = NHCO: H 2 N-AA 3 -AA 2 -AAι-resin was first washed with THF and then three eq. of the desired isocyanate, R 7 N=C=O was added followed by sufficient THF to swell the resin (-12.5 mL/gr of resin). The reaction was then placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and washed three times with CH 2 C1 2 , three times with MeOH, once with 1:1 HOAc/CH 2 Cl 2 , three times with MeOH and then lastly three times with CH 2 C1 2 to give R 7 NHCO-AA 3 -AA 2 -AAι-resin. 4. R 7 Z-AA AA -AA NHOH R 7 Z-AA 3 -AA 2 -AAi -resin is first washed with THF. Sufficient THF is added to swell the resin (-12.5 mL/gr of resin) then 25 eq. of 50% aq. NH 2 OH is added and the reaction is rotated for two days. The reaction is then filtered by suction filtration and washed with CH C1 2 , MeOH, and then CH 2 C1 2 . The filtrate is concentrated on a Speed Vac to obtain R 7 Z-AA 3 -AA 2 -AA r NHOH. Example X General experimental for R 7 Z-NR 10 C(O)CH7-AA 2 -AA,-NHOH (Tripeptide Compounds of Formula I where n = 1, m = 0, R 9 is hydrogen (A is C(O)CH 2 NR 10 ) and Z is a bond, -SO 2 -, -C=O, or -C(O)NH-) 1. BrCH 2 CO-AA 2 -AA r resin To H 2 N-AA 2 -AA 1 -resin was added twelve eq. of bromoacetic acid and twelve eq. of diisopropylcarbodiimide. Sufficient CH 2 C1 2 was added to swell the resin (-12.5 mL/gr of resin). The reaction was then placed on a spinner and rotated two hrs. The reaction was then filtered by suction filtration and washed three times with CH 2 C1 2 , three times with DMSO and then lastly three times with CH 2 CI 2 to give BrCH 2 CO- AA 2 - A A 1 -resin . 2. R 10 NHCH?CO-AA ? -AA,-resin BrCH 2 CO-AA 2 -AA 1 -resin is first washed with DMSO. Sufficient DMSO is added to swell the resin (-12.5 mlJgr of resin) followed by the addition of 40 eq. of the desired amine, R 10 NH 2 or R 7 R I0 NH. The reaction was then placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and three times with CH 2 C1 2 , three times with MeOH, once with 1 : 1 HOAc/CH 2 Cl 2 , three times with MeOH and then lastly three times with CH 2 C1 2 to give R 10 NHCH 2 CO- AA 2 -AA resin or R 7 R 10 NHCH 2 CO-AA 2 -AA resin. (If R 7 R 10 NH is used, corresponding to Z being a bond, go directly to step 4) 3. R / Z-NR , 1 l 0 u CH 7 CO-AA7-AA I -resin 3a. For Z = -SO?-: R 10 NHCH 2 CO-AA 2 -AAι -resin is first washed with aq. dioxane, then 10 eq. of the desired sulfonyl chloride, R 7 SO 2 Cl, is added. Sufficient 90% aq. dioxane was added to swell the resin (-12.5 mlJgr of resin). Then 20 eq. of diisopropylethylamine was added. The reaction was then placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and washed three times with CH 2 C1 2 , three times with MeOH, once with 1:1 HOAc/CH 2 Cl 2 , 3 times with MeOH and then lastly three times with CH 2 C1 2 to give R 7 SO 2 - NR I0 CH 2 CO-AA 2 -AA 1 -resin 3b. For Z = -CO-: To R 10 NHCH 2 CO-AA 2 -AA resin is added sufficient CH 2 C1 2 is added to swell the resin (-12.5 mlJgr of resin). Three eq. of the desired acid chloride, R 7 COCl, and three eq. of Et 3 N are then added. [A first alternative is to add to the resin sufficient CH 2 C1 is added to swell the resin (-12.5 mlJgr of resin) followed by three eq. of the desired carboxylic acid, R 7 COOH, 3 eq. of diisopropylcarbodiimide and 0.05 eq. of a 0.116 M solution of dimethylaminopyridine in THF. A second alternative is to add to the resin 3 eq. of the desired carboxylic acid, R 7 COOH, 3 eq. of HATU, 3 eq. HO At and 6 eq. of DIPEA followed by sufficient NMP is added to swell the resin (-12.5 mlJgr of resin ).] The reaction was then placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and washed three times with CH 2 θ 2 , three times with MeOH, once with 1:1 HOAc/CH 2 Cl2, three times with MeOH and then lastly three times with CH 2 C1 2 to give R 7 CO-NR 10 CH 2 -AA 2 -AA 1 -resin 3c. For Z= -CONH-: R 10 NHCH 2 CO-AA 2 -AA 1 -resin is first washed with THF, then 3 eq. of the desired isocyanate, R N=C=O, was added followed by sufficient THF to swell the resin (-12.5 mlJgr of resin). The reaction was then placed on a spinner and rotated overnight. The reaction was then filtered by suction filtration and washed three times with CH2CI2, three times with MeOH, once with 1:1 HOAc/CH 2 Cl 2 , three times with MeOH and then lastly three times with CH 2 C1 2 to give R 7 NHCO-NR 10 CH 2 -AA 2 -AA 1 -resin. 4. Removal of protecting groups If AAi or AA contains an acid labile side chain protecting group that is to be removed, the resulting resin (R 7 Z-NR 10 CH CO-AA 2 -AAι-resin) was treated with a solution of 95/2.5/2.5 TFA H 2 O, triisopropyl silane (TIS) for 2 hours. The reaction was then filtered by suction filtration and washed three times with CH 2 C1 2 , three times with MeOH, and then three times with CH 2 C1 2 . 5. R 7 Z-NR 10 C(O CH 2 -AA 2 -AAι-NHOH R 7 Z-NR 10 CH 2 CO-AA 2 -AAι -resin was first washed with THF. Sufficient THF was added to swell the resin (-12.5 mlJgr of resin) then 25 eq. of 50% aq. NH 2 OH was added and the reaction was rotated for two days. The reaction was then filtered by suction filtration and washed with CH 2 C1 2 , MeOH, and then CH 2 C1 2 . The filtrate was concentrated under vacuum to obtain R 7 Z-NR 10 C(O)CH 2 -AA 2 -AA 1 - NHOH *Note in all cases, all solid reagents are added followed by solvent. If the reagents are not solids, the solvent is added followed by the liquid reagents. For AAi or AA 2 with side chain that require deprotection this was done just prior to the NH 2 OH cleavage reaction. Typical amino acids with side chains requiring deprotection include Glu (OtBu), His (Boc) and Ser (OtBu). Example XI Isolation and Preparation of Procollagen C-Proteinase Cloning of Human PCP and Construction of the HT-1080 Vector Human Procollagen C-Proteinase (PCP, also known as Bone Morphogenetic Protein- 1 or BMP-1) was cloned by from a human fibroblast cDNA library (Stratagene, San Diego, CA). Cloning was performed by PCR based on the reported nucleotide sequence (Wozney .M., RosenN., Celeste,A.J., Mitsock L.M., Whitters,M.J., Kriz,R.W., Hewick,R.M., and Wang,E.A. (1989) direct GenBank submission accession M22488, locus HUMBMPl) using Taq polymerase, the 5' primer GCGCGCGGTACCCGCCCCGCCAGCATGCCCGGCGTGGCCCGCCTGCCGC TGCTGCTCGGGCTGCTGCTGCTCCCGCGTCCCGGCCGGCCGCTGGACTTG GCCGACTACACCTATGACCTGGC (SEQ ID NO: l)(Oligo Therapeutics, Inc., Wilsonville, OR), and the 3' reverse strand primer CCGCTCGAGCCTCACTGGGGGGTCCGGTTTCTTTTCTGCACTCGGAATTT GAGCTGGTG (SEQ ID NO:2) (Gibco) to yield the entire full-length nucleotide encoding the signal sequence, propeptide, catalytic domain, and all C-terminal domains to the natural translation termination site. The PCR product was purified by gel electrophoresis using the Wizard DNA Purification Kit (Promega, Madison, Wl) and ligated directly into the mammalian expression vector pCR3.1 (Invitrogen, Carlsbad, CA) by the TA cloning method. Ligated product was used to transform E coli strain TOP10F' (Invitrogen, Carlsbad, CA) by a standard heat-shock method, and transformants were selected by restriction analysis of purified plasmid using the enzymes HindHI and BamHI. Transformants testing positive for the PCP insert were submitted for sequencing using the Perkin-Elmer / ABI system. Two clones were selected that, combined, encoded the entire amino acid sequence identical to the one predicted by Wozney et al. The two clones were recombined by restriction using the enzymes Bbrl, which cleaved at a naturally occurring internal site, and EcoRV, which cleaved at the junction of the insert and vector. The excised fragments were religated into EcoRV-treated pCR3.1. The resulting construct contained the entire coding sequence identical to that reported by Wozney et al. with the exception of two silent mutations in the signal sequence, G->A at both positions 39 and 45 counting from the translation initiation site (ATG). The completed plasmid construct was amplified in E. coli DH5 i and purified using anion exchange chromatography (MaxiPrep columns from Qiagen (Valencia, CA) catalog #12162). Transfection of HT-1080 and Selection of the PCP-Expressing Clone The human fibrosarcoma line HT-1080 (ATCC) was grown in high glucose DMEM (DMEM-HG) supplemented with 10 % heat-inactivated fetal bovine serum (HI-FBS) in 100 mm culture dishes (Falcon, Becton Dickenson, Franklin, NJ) and transfected with 2 ug of purified plasmid using the standard method for Lipofectamine (Gibco, Bethesda, MD) in serum free medium. Stable transfectants were selected by treating the plated culture with 400 ug/ml G418 (Gibco). After selection for 10 days, the adherent single colonies were picked from the plate, replated in 12-well plates and grown until confluent. Individual stable colonies were screened for PCP expression by TaqMan (Perkin-Elmer, Foster City, CA) analysis using equivalent amounts of total RNA, the 5' primer GACGAAGAGGACCTGAGGGCCTT (SEQ ID NO:3) (Perkin-Elmer, Foster City, CA), the 3' reverse strand primer TTCCTGGAACTGCAGCTTTGA (SEQ ID NO:4) (Perkin-Elmer, Foster City, CA), and the reverse strand probe TGCCGTCTGAGATCCACAGCCTGCT (SEQ ID NO:5) (Perkin-Elmer). A stable line, HT-1080/hPCP-23, was chosen based on the highest PCP mRNA expression level in the TaqMan screen. Stocks of the HT-1080/hPCP-23 stable line were transferred to DMEM-HG supplemented with 5 % HI-FBS and 10 % DMSO (no G418 added) and were slowly frozen at -70 °C overnight, then transferred to a liquid nitrogen bath for long-term storage. Revitalized HT-1080/hPCP-23 were maintained in DMEM-HG supplemented with 10 % HI-FBS and 250 ug/ml G418 for no more than 7 passages. Expression of PCP for harvest was carried out by replating and growing HT-1080/hPCP-23 on rat tail type I collagen-coated plates (Falcon) in OptiMEM (Gibco) serum free medium without G418 for 24 hr. Production of PCP in HT1080 cells The HT1080 cells that were transformed to produce PCP were adapted to grow in suspension in optiMEM medium (GIBCO) supplemented with 5% fetal bovine serum and 4 ml/L G418 (GIBCO). The culture was maintained at 37C and the dissolved oxygen at 30%. Typically batch sizes of 10 liters were produced. When the cell density reached 4-6 X 10 5 cells/ml, the culture fluid was collected and filtered through 0.2 um membranes. Alternatively, the cell culture was perfused with fresh media at the rate of 0.8 to 1.0 culture volume/day. The density of the perfused cultures reached 1-2.5 X 10 6 cells/ml and were maintained up to two weeks with continuous harvests. Purification of PCP from HT1080 Cells A column packed with Dyematrex Gel Green A (Millipore, Bedford, MA) was equilibrated against 50 mM HEPES, pH7.2, containing 6mM CaCl 2 and 0.3M NaCl. After the HT1080 cell culture fluid was loaded, the column was washed with 10 column volumes of the equilibration buffer containing 1.0 M NaCl. PCP was eluted with 50 mM HEPES pH 7.2 containing 3 M NaCl, 2 M urea and 6 mM CaCl 2 . Eluate fractions were pooled and concentrated to 150-200 mis and dialyzed against 4.0 liters of 50 mM HEPES, 6 mM CaCl 2 , pH 7.2 overnight. The material was then centrifuged at 5,000 g for 15 minutes to remove precipitates. The PCP containing sample were stored at -20C until ready for further processing. The PCP containing sample was thawed and diluted with 50 mM HEPES pH 7.2 containing 6 mM CaCl 2 , if necessary to bring the NaCl concentration to 0.1-0.15 M The pH was adjusted to 6.1 with 2 N HC1. The protein solution was filtered through a 0.45 um filter to remove any precipitate. This preparation was then loaded onto a column packed with Q-Sepharose High Performance (Pharmacia, Piscataway, NJ) which had been equilibrated with 50mM HEPES pH 6.7 containing 6 mM CaCl 2 and 0.15 M NaCl. The PCP was not retained in the column and was therefore in the flow through fractions. The PCP was concentrated to 1 mg/ml and used for screening. Production of PCP in Drosophila Cells Drosophila cells which had been transformed to produce PCP were grown in bioreactors at a typical batch volume of 10 liters in SF900 II SF medium (GIBCO). The temperature was maintained at 30C and the dissolved oxygen at 30%. Periodically the cells were fed a cocktail consisting of glutamine, lipids and yeastolate. When cell densities reached 30-50 X 10 6 cells/ml, supernatants were harvested by centrifugation and concentrated by ultrafiltration using a 30Kd membrane. Purification of PCP from Culture Fluid from Drosophila Cells Culture fluid from the drosophila cells was concentrated 8 fold and the pH adjusted to 7.1-7.2 if necessary. The culture fluid was centrifuged at 3000 g for 10 minutes and filtered through 0.45 um filters. The culture fluid was then loaded onto columns packed with carboxy-sulfone packing material (J.T. Baker/Mallinckrodt, Phillipsburg, NJ) which had been equilibrated with 0.1 M NaCl, 50 mM HEPES, 6 mM CaCl 2 , pH 7.2. After being loaded, the column was washed with 10 column volumes of the equilibration buffer. Retained proteins were eluted with a gradient of 0.1 to 1.0 M NaCl in 9 column volumes. Fractions that had PCP activity were pooled for further purification. The PCP eluted off the carboxy-sulfone column was loaded onto a Dyematrex Gel Green A (Millipore, Bedford, MA) column that had been equilibrated with 50 mM HEPES, pH 7.4 containing 0.3 M NaCl and 6 mM CaCl 2 . The column was then washed with the equilibration buffer containing 1 M NaCl. Retained proteins were eluted with 50 mM HEPES, pH 7.4, 3 M NaCl, 2 M urea, 6 mM CaC - The elution peak was concentrated and dialyzed against 50 mM HEPES, pH 7.4 containing 0.3 M NaCl, 6 mM CaCl 2 . The preparation was centrifuged at 3000 g for 10 minutes. Brij 35 (Sigma, Madison, Wl) was added to the supernatant to a final concentration of 0.02%. This preparation was used for screening. Example XII Isolation of Collagenase enzymes The catalytic domain of human collagenase-1 was expressed as a fusion protein with ubiquitin in E. Coli as described in Gehring, E.R. et al., J. Biol. Chem., 270, 22507, (1995). After purification of the fusion protein, the collagenase-1 catalytic domain was released by treatment with ImM of aminophenylmercuric acetate (APMA) for 1 hour at 37 °C and then purified by zinc chelate chromatography. Human collagenase-2 and gelatinase B were isolated in active form from buffy coats as described in Mookhtiar, K.A. et al., Biochemistry, 29, 10620, (1990). The propeptide and catalytic domain portion of human collagenase-3 was expressed in E. Coli as an N-terminal fusion protein with ubiquitin. After purification, the catalytic domain was released by treatment with 1 mM APMA for 1 hour at 37 ° C, and then purified by zinc chelate chromatography. Rat collagenase-3 was purified in active form from the culture media of uterine smooth muscle cells as described in Roswit, W.T. et al., Arch. Biochem. Biophys., 225, 285-295 (1983). Example XHI Inhibition of Procollagen C-Proteinase activity The ability of the compounds to inhibit PCP has been demonstrated in the following in vitro assays utilizing a synthetic peptide as the substrate. Assay A A continuous assay was performed using 20 μM substrate (Dabcyl-Pro-Tyr- Tyr-Gly-Asp-Glu-Pro-n-Leu-Edans) (SEQ ID NO:6). The final assay conditions were 20 μM substrate, 50 mM HEPES pH 7.5, 50 mM NaCl, 3% DMSO, 37°C and PCP enzyme. Product formation was monitored by fluorescence spectroscopy, Ex. = 335 nm, Em. = 490 nm. The IC 5 o was calculated from plots of the initial velocity vs. compound concentration. Assay B Eighty μL of buffer A (20 mM HEPES) containing the desired concentrations of the test compound in DMSO or carrier vehicle was mixed with lOμL of approx. lmg/mL PCP enzyme and lOμL of O.lmM substrate both in 20mM HEPES. The contents are mixed, incubated at room temperature for 1-2 hours and fluorescent readings taken with a Victor plate reader (Ex. 405nm, Em. 460nM at 2000-40,000 lamp energy, 0.1-1 sec/well). The substrate was DACM-Cys-Pro-Tyr-Gly-Asp-Glu- Pro-nLeu-Lys-FtTC-OH. (SEQ ID NO:7) (DACM = dimethylamino- coumarylmaleimide, FITC = fluorescein isothiocyanate). The IC 5 o was calculated from plots of the initial velocity vs. compound concentration. Additional in vitro assays using native procollagen as the substrate may also be used and these assays are described in more detail in WO 97/05865 ("C-Proteinase Inhibitors for the Treatment of Disorders Relating to the Overproduction of Collagen"). The compounds in Tables I-IU, V and VI had IC 50 's in the range of 0.02 to 200 μM. The compounds in Table IV had IC 50 's in the range of 10-1000 μM. Example XJN Measurement of Collagenase Activity The collagenase-1, collagenase-2 and collagenase-3 inhibitory activity of compounds of this invention in vitro was determined based on the hydrolysis of MCA-Pro-Leu-Gly-Leu-DPA-Ala-Arg-ΝH 2 (SEQ ID NO: 8) (Bachem, Inc.) at 37 °C as described in Knight, C.G., et al., FEBS Lett.. 296(3): 263-266 (1992). The collagenase enzyme was diluted with assay buffer (50 mM Tricine pH 7.5, 200 mM NaCl, 10 mM CaCl 2 , and 0.005% Brij-35) containing 10 μmole of above substrate dissolved in DMSO. Compounds of the invention dissolved in DMSO or only DMSO (control samples) were added such that the final DMSO concentration in all assays was 2.5%. The fluorescence changes were monitored with a Perkin-Elmer LS-50B fluorimeter using an excitation wavelength of 328 nm and an emission wavelength of 393 nm. Selected compounds from Tables I- VI were 10-1000 more selective for PCP inhibition than for the human collagenase enzymes.

Claims: Claims 1. A compound selected from the group of compounds represented by Formula (I): (I) wherein: R 1 and R are, independently of each other, hydrogen or alkyl; R 2 is: (i) cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heteroaralkenyl, heterocyclo or heterocycloalkyl; or (ii) -(alkylene)-B-X where B is -O-, -NR 8 -, -S(O) n - (where n is 0, 1 or 2), -C=O, -CONR 8 -, -NR 8 CO 2 -, NR 8 SO 2 - or -C(=NR 8 )NR 8 SO 2 -(where R 8 is H or alkyl), and X is cycloalkyl, cycloalkylalkyl, aryl, aralkyl heteroaryl or heteroaralkyl; or (iii) -(alkylene)-B-X where B is -NR 8 CO- (where R 8 is H or alkyl), and X is cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; or (iv) R and R form an alkylene or heteroalkylene chain; R 3 is hydrogen or alkyl; R 6 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; R 5 is: (i) hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heteroaralkenyl, heterocycloalkyl, heteroalkyl, or -(alkylene)-C(O)-X' where X 1 is alkyl, hydroxy, alkoxy, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy, heteroaralkyloxy or NR'R" (where R' and R" are independently H or alkyl, or R'and R" form an alkylene chain); or (ii) R 5 and R 4 form an alkylene chain; or (iii) R 5 and R 6 form an alkylene chain; n is 0 or 1; A is -C(=O)-CH(R 9 )-(CH 2 ) m -N(R 10 )- wherein: m is an integer from 0-5 inclusive; R 9 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heteroalkyl, or -(alkylene)-C(O)-X 1 where X 1 is alkyl, hydroxy, alkoxy, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy, heteroaralkyloxy or NR'R" (where R' and R" are independently H or alkyl, or R' and R" form an alkylene chain); and R 10 is hydrogen, alkyl, aralkyl or heteroaralkyl; Z is Y-B wherein: Y is alkylene or a bond; and B is -CO-, -C(O)O-, -CONR 8 -, -SO 2 -, or -SO 2 NR 8 - (where R 8 is hydrogen or alkyl), alkylene (optionally substituted by hydroxy, alkoxy, amino, monoalkylamino or dialkylamino) or a bond; R 7 is cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; provided that when n = 0 and Z is SO 2 , then R 2 does not contain an imidazole group; and their pharmaceutically acceptable salts, prodrugs, individual isomers, and mixtures of isomers. 2. The compound of Claim 1 wherein: n is O. 3. The compound of Claim 2 wherein R 3 and R 6 are hydrogen. 4. The compound of Claim 3, wherein: R 2 is aralkyl or heteroaralkyl. 5. The compound of Claim 4 wherein: Z is -C(O)O- or -S(O) 2 -. 6. The compound of Claim 5 wherein: R 2 is optionally substituted benzyl or heteroaralkyl. I . The compound of Claim 6 wherein, R is 4-t-butoxybenzyl, 3-chlorobenzyl, 3-indolyl methyl, 2-thienylmethyl, 4-imidazolylmethyl or 4-thiazolylmethyl. 8. The compound of Claim 7 wherein R 2 is 4-thiazolylmethyl. 9. The compound of Claim 8 wherein: R 7 is aryl, aralkyl, heteroaryl or heteroaralkyl. 10. The compound of Claim 8 wherein: Z is -C(O)O- and R 7 is optionally substituted benzyl. I I. The compound of Claim 9 wherein: n Z is -SO 2 - and R is aryl or heteroaryl. 12. The compound of Claim 10 or Claim 11, wherein: R 1 and R 4 are hydrogen and R 5 is alkyl. 13. The compound of Claim 12 wherein R 5 is (S,S)-l-methylpropyl. 14. The compound of Claim 3, wherein: R 2 is (alkylene)-B-X where B is -O-, -NR 8 -, -S(O) n - (where n is 0, 1 or 2), - C=O, -CONR 8 -, -NR 8 CO 2 -, -NR 8 SO 2 - or -C(=NR 8 )NSO 2 -(where R 8 is H or alkyl), and X is cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl. 15. The compound of Claim 14, wherein: Z is -C(O)O- or -S(O) 2 -. 16. The compound of Claim 15, wherein R 2 is -CH 2 -B-X and B is -NHCO2- and X is benzyl. 17. The compound of Claim 16 wherein: R »7 i •s aryl or aralkyl. 18. The compound of Claim 17, wherein: R 1 and R 4 are hydrogen and R 5 is alkyl. 19. The compound of Claim 18 wherein R 5 is (S,S)-l-methylpropyl. 20. The compound of Claim 1 wherein: n is 1. 21. The compound of Claim 20 wherein m is 0 and R 3 and R 6 are hydrogen. 22. The compound of Claim 21, wherein: R 2 is aralkyl or heteroaralkyl. 23. The compound of Claim 22, wherein: Z is -C(O)O- or -S(O) 2 -. 24. The compound of Claim 23, wherein: R is optionally substituted benzyl or heteroaralkyl. 25. The compound of Claim 24 wherein R 2 is 4-t-butoxybenzyl, 3-chlorobenzyl, 3-indolyl methyl, 2-thienylmethyl, 4-imidazolylmethyl or 4-thiazolylmethyl. 26. The compound of Claim 25 wherein R 2 is 4-thiazolylmethyl. 27. The compound of Claim 26 wherein: R 7 is aryl, aralkyl, heteroaryl or heteroaralkyl. 28. The compound of Claim 27 wherein: Z is -C(O)O- and R 7 is benzyl. 29. The compound of Claim 27 wherein: Z is -SO2- and R 7 is aryl. 30. The compound of Claim 28 or 29, wherein: R 1 and R 4 are hydrogen and R 5 is alkyl. 31. The compound of Claim 30 wherein R 5 is (S,S)- 1-methylpropyl 32. The compound of Claim 21, wherein: R 2 is (alkylene)-B-X where B is -O-, -NR 8 -, -S-, -C=O, -CONR 8 -, -NR 8 CO 2 -, - NSO 2 - or -C(=NR 8 )NSO 2 -(where R 8 is H or alkyl), and X is cycloalkyl, cycloalkylalkyl, aryl, aralkyl heteroaryl or heteroaralkyl. 33. The compound of Claim 32, wherein: Z is -C(O)O- or -S(O) 2 - . 34. The compound of Claim 33, wherein R 2 is CH 2 -B-X and B is -NHCO 2 - and X is benzyl. 35. The compound of Claim 34 wherein: R 7 is aryl or aralkyl. 36. The compound of Claim 35, wherein: R 1 and R 4 are hydrogen and R 5 is alkyl. 37. The compound of Claim 36 wherein R 5 is (S,S)-l-methylpropyl. 38. A pharmaceutical composition comprising the compound of any one of Claims 1 to 37 and a pharmaceutically acceptable excipient. 39. A process for preparing the compounds of Claim 1 by: (i) treating a compound of Formula II wherein L is a leaving group and R 1 - R 7 , A, n and Z are as defined in Claim 1 with hydroxylamine or a protected derivative thereof, and (ii) deprotecting as necessary and isolating the compound of Claim 1. (II) 40. A compound as claimed in Claim 1 whenever prepared according to a process as claimed in Claim 39. 41. A compound as claimed in any one of Claims 1 to 37 as a therapeutically active substance. 42. Use of a compound as claimed in any one of Claims 1 to 37 for the preparation of a medicament comprising a compound as active ingredient as claimed in any one of Claims 1 to 37 for the treatment of a fibrotic disease, preferably acute respiratory distress syndrome. 43. A method of treating fibrosis comprising administering to a patient in need thereof an inhibitor of procollagen C-proteinase that is at least ten-fold more selective for procollagen C-proteinase over both collagenase-1, collagenase-2 and collagenase-3. 44. The invention as hereinbefore described.

Inventors: DANKWARDT SHARON MARIE, VAN WART HAROLD EDGAR, WALKER KEITH ADRIAN MURRAY, DANKWARDT, SHARON, MARIE, VAN WART, HAROLD, EDGAR, WALKER, KEITH, ADRIAN, MURRAY
Applicants: HOFFMANN LA ROCHE, F. HOFFMANN-LA ROCHE AG
Application year: 1999
Main classification: C07K5
IPC codes: A61K38, A61P1, A61P9, A61P11, A61P13, A61P17, A61P19, A61P21, A61P37, A61P43, C07K1, C07K5, C12N9, C12N15, C40B40, C40B50