Radiation source for endovascular radiation treatment in form of a wire

Abstract: The present invention relates to a radioactive radiation source in form of a wire comprising a matrix of a ductile and/or plastic bindermaterial and a radioactive and/or activatable material. Preferably the elastic bindermaterial is a metal, a metal alloy or a radiation resistant plastic material or mixture thereof. The radioactive or then activated activatable material is a β-emitter, a γ-emitter or x-ray emitter. The source may further comprise a means for containment. The radioactive radiation source of the invention is preferably used in intravascular radiation treatment e.g. to treat cancer, tumours, non-malign cell growth, or scar tissue or to prevent restenosis.

Description: The present invention relates to a radiation source for use in endovascular radiation treatment with fission product radioactivity and/or irradiation activated radioactivity, which radiation source is provided in the form of a wire and may be suitable for being delivered in a catheter to the selected site to be treated within the vascular system of a patient. BACKGROUND OF THE INVENTION Endovascular radiation treatment is the present method of choice to prevent formation of scar tissue in a blood vessel which has been injured in various ways, for example, as trauma from surgical or diagnostic procedures or for treatment of cancer and tumours. One area of the vascular system of particular concern with respect to such injury relates to coronary arteries that are subjected to procedures for removing or reducing blockages due to plaque within the arteries. Partial and even complete blockage of the coronary arteries by the formation of an arteriosclerotic plaque is well known and a serious medical problem. Such blockages may be treated using arterectomy devices which mechanically remove the plaque, hot or cold lasers which vaporise the plaque, stents which hold the artery open and other devices and procedures well known in the art. The most common of them is the percutaneous transluminal coronary angioplasty (PTCA), more commonly referred to as balloon angioplasty. Long term success of balloon angioplasty procedures is largely limited due to restenosis or reclosing of the intraluminal passageway through the artery by formation of scar tissue. Restenosis is experienced in approximately 30 to 50 % of the patients within six months after balloon angioplasty. Apparently, restenosis is to a significant extent a natural healing response to the vessel injury caused by inflation of the angioplasty balloon. Prior attempts to inhibit restenosis have included the use of various light therapies, chemotherapeutical agents, stents, arterectomy devices, hot and cold lasers and so on. The most promising approach to inhibit restenosis after PTCA is the use of endovascular radiation therapy, i.e. the exposure of the potential or actual restenotic site to ionising or radioactive radiation (brachytherapy). Another important field for radiation treatment is the localised, internal radiation treatment of cancer, tumours and/or non-malignant cell growth. The advantage of a localised radiation treatment is that the healthy tissue surrounding said tumour is exposed to the possibly hazardous radiation to only a very minor extent, since the radiation can be directed specifically to the target region of the tumour. Although endovascular radiation therapy in general has been applied advantageously, the devices available for delivery of radiation sources and the radiation sources themselves have certain drawbacks which limit their usefulness. Typically, the devices include a catheter, which is directed by way of a guide wire inserted therein to the site of treatment. The catheter is then used to internally direct the radiation source to the site of treatment. One typical problem encountered with the catheter and/or the radiation source is related to stiffness of the source which is essentially proportional to its length. Thus shorter radiation sources are typically used to allow them to follow the tortuous anatomy of the heart. To irradiate the entire site of the vessel to be treated a so-called "stepping-treatment" is then employed, wherein the radiation source is moved back and forth in the vessel. Since, however, exact positioning is not possible in a constantly moving vessel, irradiation is not precisely controllable in this "stepping-treatment". Thus, long sources are desirable which allow for one-step treatment of the site in its entire length. For example, US-A-5,833,593 discloses a flexible source wire which is modified at its treatment end to receive a radioactive element. A plug seals the unmodified section of the source from the lumen of the modified segment or container which contains the radioactive element. Both ends of the source wire are sealed to prevent leakage of radioactivity. US-A-5,683,345 discloses an apparatus and a method for brachytherapy. The radiation source used according this document consists of individual treating elements which may be joined together to form a train of treating elements by use of several lengths of high tempered spring wire to prevent the treating elements from becoming too spaced apart while moving through the catheter. WO-A-97/19706 discloses a radioactive composite consisting of a polymeric matrix, preferably a biodegradable polymeric matrix, and a radioactive powder of very fine radioactive particles. This polymeric matrix includes the radioactive powder. US-A-5,322,499 discloses a radioactive core material made of an alloy of iridium and platinum, enclosed in a sheath of pure metallic platinum. The core is considered brittle and obviously breaks under mechanical strain. US-A-4,994,013 discloses a radioactive seed or radiation source comprising a radio opaque central marker rod covered by a bindermaterial incorporating a radio active adsorbing material and radioactive material adsorbed on that radioactive adsorbing material. The document requires a plastic or polymeric bindermaterial for holding the radioactive adsorbing material. Other typical drawbacks encountered with prior art radiation sources and devices for delivering the same to the site to be treated are related to the duration of exposure, controllability of the radiation exposure (dosage, homogeneity of treatment), the necessity to conduct a "stepping-treatment", or difficulties in completely and controllably retracting the radiation source from the catheter and therefore the risk of undesirable exposure of both the patient and any medical personal "handling" the treatment device. To solve this problem the European patent application No. 99 111 100.6 discloses a radiation source comprising a deflectable container comprising at least two seeds or radiation emitting elements. The deflectable container joins the relatively short and stiff seeds to form a flexible radiation source. Similarly EP 99 111 099.0 teaches to form a flexible radiation source by directly linking the individual seeds together while still allowing relative movement. Still both radiation sources have the problem that they are limited with respect to miniaturisation in that they either require the container or require providing the linkage between the seeds. The latter radiation source further implies the risk that the linkage between the seeds is interrupted during the treatment. In this case it may be difficult to retract the entire radiation source out of the body to be treated. Further, in manufacture of the seeds or source there is the constant demand for miniaturisation, since only miniaturisation will provide sufficiently small sources to treat smaller vessels of the patient and thus to successfully allow for cancer or tumour therapy in other anatomical sites. It is the object of the invention to overcome these and other drawbacks of prior art radiation sources. SUMMARY OF THE INVENTION This object is solved by the radiation source of the invention as disclosed in the appending claims. More in detail the present invention provides: Radiation source for brachytherapy in form of a wire comprising a matrix of a ductile bindermaterial and a radioactive and/or activatable material, wherein the radioactive and/or activatable material is used in form of an insoluble compound, said compound differing from said bindermaterial, and is provided in fine divided form and is mixed with the bindermaterial, said bindermaterial consisting of a metal, or a metal alloy. Preferably, the bindermaterial has a low capture cross-section for the method of activation of the activatable material and/or a low attenuation factor for the emitted radiation. The ductile bindermaterial is of non-ceramic nature and comprises a metal, a metal alloy. Preferably, the radioactive or then "activated" material is selected from β-emitters, γ-emitters and/or x-ray emitting materials. More preferably the radioactive material is a nuclear fission product or is an activatable material activated by nuclear excitation by particles, preferably neutrons, protons or photons. Most preferably the material has a maximum particle energy of β-radiation of at least 500 keV, or a photon energy of γ- and/or x-ray radiation in the range of 20 to 100 keV. In a preferred embodiment this radioactive and/or activated material is selected from Sr/Y-90, Tm-170, P-32, Cl-36, Ce-144, Tb-160, Ta-182, Tl-204, W/Re-188, Ir-192 and Se-75 or mixtures thereof. The radioactive and/or activatable material is used in form of a compound insoluble under the prevailing conditions, preferably in form of an oxide, fluoride, titanate, carbonate, cermet or ceramic. The radiation source of the present invention generally has a ratio of length to diameter of ≥ 2:1, a length in the range of less than 1 to 25 mm and a diameter in the range of 0.01 to 1 mm. The radiation source of the invention may further comprise a means for containment which is preferably a capsule or a coating. The radiation source of the invention can be used for radiation treatment of a mammal, preferably a human being. Preferably the radiation source of the invention is used in brachytherapy, preferably endovascular brachytherapy, to treat restenosis, cancer, tumours and non-malignant cell growth or scar tissues. The present invention makes possible the objects of (1) providing a radiation source having increased mechanical stability at sufficient flexibility of the source to follow the bends of a small vessel, of (2) providing improved security in view of leakage of radioactive material in case the source is damaged or otherwise manipulated during manufacture thereof e.g. by cutting or forming the same, of (3) providing a considerable simplification in manufacture of producing the radiation source, especially when activatable materials are used, and of (4) allowing for miniaturisation of the source in the sub-millimeter region. DETAILED DESCRIPTION OF THE INVENTION The present invention provides a radioactive radiation source in form of a wire comprising a matrix of a ductile bindermaterial and a radioactive and/or activatable material as defined in claim 1. Said activatable material can be transformed into an activated material, usually in the form of an isotropically enriched stable isotope, to obtain the activated radiation source to be used in therapy. The term "wire" as used herein is intended to encompass any form of a radiation source having a ratio of its longitudinal axis (length) to its diameter of ≥ 2:1. Thus, the radiation source is intended to have an elongated shape. Its cross-section needs not necessarily be circular, but may encompass any suitable cross-section such as circular, oval, elliptic, polygonal, preferably quadratic or rectangular, hexagonal, octagonal or an irregular shape, provided this cross-section does not interfere with its use in a catheter and does not hamper advancing the radiation source through a catheter. The term "diameter" therefore refers to any axis normal to the longitudinal axis. The term "wire" further implies the radiation source having ductile or elastic or flexible properties to allow the radiation source to easily follow the bendings of vessels within the body to be treated. Preferably the bindermaterial used as a matrix is therefore generally a non-ceramic material and consists of a metal, or a metal alloy. Generally, the matrix bindermaterial is non-ceramic in nature to avoid the stiffness of this material. All known metals and/or alloys which can be formed to wires can be used as matrix material. Preferably the matrix or bindermaterial has a small capture cross section so that the applied activation irradiation method only activates the activatable and when activated radioactivity emitting material to obtain the desired type of radiation. Another preferred property of the matrix or bindermaterial is a low attenuation factor for the emitted type of radiation. The latter property allows to reduce self-absorption of the radiation source thereby providing a more homogenous or uniform radiation field. The first property reduces the likelihood of activating the bindermaterial of the matrix, which will therefore preferably be non-active. The bindermaterial used as the matrix further preferably forms radioactive activation nuclides having a short half-live (preferably less than one day), in cases where the bindermaterial is activated by the activation treatment to activate the radiation emitting element at all. More preferably the bindermaterial is not activated during activation of the radiation emitting element. Examples of the metal to be used as the ductile bindermaterial include metals selected from the group consisting of Al, Ag, Au, Pb, Cd, Ce, Cr, Co, Cu, Fe, Hg, Hf, Bi, In, Mg, Mn, Mo, Nb, Ni, Pd, Pt, Pr, Re, Rh, Sn, Si, Ta, Ti, Tb, Th, V, W, Y, Yb, Zn, Zr or their alloys and mixtures thereof. The ductile and/or plastic bindermaterial may also comprise a metal alloy selected from the group consisting of aluminum alloys such as Al/Mg, Al/Cu, Al/Cu/Mg, Al/Mg/Si, Al/Cr, Tinal alloy BB, copper alloys such as brass, bronzes, iron alloys such as Fe/Cr, Fe/Ni, Fe/Cr/Ni, Fe/Cr/Al, nickel alloys such as Ni/Ti, Ni/Cr, nitinol, platinum alloys, titanium alloys such as Ti/Al, Ti/Al/V, Ti/Mo, Woods alloy, Inconel, and amalgams. More preferably, the bindermaterial is one or a mixture of materials selected from the group Ag, Cu, Al, Ti, Ni, the amalgams and Woods alloy. Most preferably the bindermaterial is aluminum or an alloy thereof. The matrix material may be modified by use of magnetic or other magnetisable materials to provide magnetic radiation sources which can e.g. magnetically be linked to a transfer wire used to advance and retract the radiation source within a catheter lumen. The radiation emitting element or radioactive material can be a β-emitter, γ-emitter and/or an x-ray emitting nuclide. The radiation emitter can be a fission product or can be an irradiation activated activatable radiation emitter. The term "activatable material" means a non-radioactive material, which can be transformed into a radioactive emitter e.g. by particle irradiation. The term "activated material" refers to the material obtained from said activation. Activatable materials are preferred, since the radiation source of the invention can be formed by routine steps without requiring appropriate equipment to shield the manufacturing personal and equipment from radiation. The final radiation source is then activated for example by excitation of an activatable material or nucleus by bombardment with charged and uncharged particles, preferably neutrons, protons or photons. Preferred activatable materials are materials activatable by the above nuclear reactions. More preferably these materials have a maximum particle energy of beta radiation of at least 500 keV and a photon energy for γ-radiation and/or x-ray radiation between 20 keV and 100 keV. These radioactive materials are soft emitters which are most desirably used in treatment of biologic materials due to their short attenuation distance, more in detail these materials are desirably due to their local ionizing effect and thus localized biological/medical effect. By choice of the above emitters, the probability for emission of γ-energies greater than 100 keV is preferably reduced to a better tolerable degree. By use of these preferred β-emitters and/or γ-emitters and x-ray nuclides the necessary amount of radiation can further easily be introduced into the radiation source of the invention in form of a wire even in case this wire has very small dimensions in the sub-millimeter region. In a preferred embodiment the radioactive (fission product) or activated material is selected from the group consisting of Sr/Y-90, Tm-170, P-32, Cl-36, Ce-144, Tb-160, Ta-182, Tl-204, and W/Re-188, Ir-192 and Se-75 or mixtures thereof. More preferably, the activatable material comprises Tm-170. In all circumstances the radioactive or activatable/activated material differs from the bindermaterial used as the matrix. Depending on the type of material used, the radioactive and/or activatable material is used in form of a compound insoluble under the prevailing conditions, preferably in form of an oxide, fluoride, titanate, carbonate, cermet or ceramic. For producing the radiation source of the invention the radioactive and/or activatable material is provided in fine divided form, preferably in form of a powder or granules and is mixed with the bindermaterial of the matrix. After mixing the wire is formed by conventional techniques to the desired dimensions, e.g. by rolling, casting, forging etc. In case an activatable material is used, the production process to make the radiation source of the invention is simplified as all the fabrication steps to make the wire can be done using the inactive isotope. Namely, there are no radiological dangers to personnel during manufacture and use of the inactive isotope removes the requirement for complex equipment and handling procedures e.g. in enclosed boxes, necessary for the manufacture and processing of radioactive materials. The radioactive radiation source of the present invention may further comprise a means for containment. This means for containment is preferably a sealed capsule preferably in tubular form to contain the wire comprising the matrix and the radioactive material. In another embodiment the means for containment may be a coating which prevents leakage of radioactivity from the wire. In case of a capsule this is preferably provided in form of a tube sealed on both ends. The capsule may be made from metals or alloys such as steel, preferably stainless steel, V, Ti, Ni, Au, Pt and mixtures and alloys thereof. In case of a coating this may comprise Ni, Cr, Co, Au, Pt, C or mixtures thereof. Such coating may have a thickness of several nm to several 10 µm to prevent leakage of activity. A coating may further be made from radiation resistant plastic materials or mixtures thereof with one of the above materials, if desired. In general the means for containment is made from a material which has like the bindermaterial of the matrix a small capture cross section for the method used to activate the activatable material and/or has a low attenuation factor for the emitted radiation. Preferably it forms radioactive isotopes or activation nuclides having a short half-life (preferably less than one day), in case the radiation source is activated after manufacture, if it is activated at all. The amount of radioactivity provided by the radiation source of the present invention is typically in the range of up to 925 GBq (25,000 mCi) per centimeter of vessel to be treated, depending on the radioactive and/or activated material used. The emitted radiation should be sufficient to deliver a desired dosage from 1 to about 100 Gy (100 to about 10.000 rads), preferably about 7 to 50 Gy (about 700 to 5.000 rads) in about 2 to 10 minutes to the tissue to be treated. The radiation source of the invention preferably has a ratio of length to diameter in the range of ≥ 2:1, preferably 5:1 to 25:1, more preferably 8:1 to 17:1. It further may have a length in the range of less than 1 to 25 mm, preferably 1 to 15 mm, more preferably 2.0 to 10 mm and most preferably 2.5 to 5 mm and may also have a diameter in the range of 0.01 to 1 mm, preferably 0.1 to 0.8 mm, more preferably 0.1 to 0.5 mm and most preferably 0.2 to 0.3 mm. The radiation source of the invention can be used in intravascular radiation treatment of a mammal, preferably of a human being. More precisely the radiation source of the invention can be used to treat cancer, tumours and other non-malignant cell growth, scar tissue and most preferably to prevent restenosis after balloon angioplasty. The radiation source of the invention can be used with any known device or apparatus to position the same within the body to be treated. Such apparatus typically comprises a catheter to securely advance the radiation source within the vessels of the body to be treated. The radiation source of the invention can be used as such or can be used as a seed to form a train of radiation emitting elements or seeds. In a preferred embodiment at least two radiation sources of the present invention are used as seeds to form a train of radiation element as disclosed in the European patent applications 99 111 100.6 and 99 111 099.0. The invention will now be further disclosed by way of specific examples. These examples are given for purpose of illustration only and are not intended to limit the scope of protection. Example 1 Thulium 170 wire The present example refers to a small thulium oxide/aluminium wire as the radiation source. In the first step naturally occurring Tm 169 2 O 3 in form of small particles is mixed with aluminium powder to obtain an evenly distributed mixture of the two materials. The mixing ration of thulium oxide to aluminium is 15 wt% to 85 wt%. After mixing the material is pressed in and formed according to known procedures into a small wire of approximately 0.3 mm diameter and 2.5 mm length. The wire is fitted into a thin welded pure vanadium capsule which capsule is subsequently sealed to encapsulate the thulium oxide/aluminium wire insert. The entire capsule is then placed on a nuclear reactor to undergo neutron activation. This creates active Tm 170 from Tm 169 and the fabrication process of the source is complete, and a radiation source of 0.4 mm outer diameter and 3.0 mm length can be obtained. In case pure vanadium is used as the encapsulating material, this capsule like the aluminium as the bindermaterial of the matrix develops no long-living radioactive isotopes during neutron bombardment. Therefore, both the outer encapsulation and the wire bindermatrix remain non-radioactive. Example 2 Strontium 90 wire The second example refers to a small strontium fluoride/aluminium wire. In this case radioactive Sr 90 F 2 in form of a powder is mixed with aluminium powder in an enclosed box. The mixing ratio is 10 wt% SrF 2 to 90 wt% Al. The mixture is then pressed and processed to a wire according to known proceedings, although all these proceedings have to be carried out under containment conditions to prevent irradiation of personnel and equipment. The finally obtained wire has dimensions of 0.5 mm diameter and 2,5 mm length. According to another embodiment the aluminium matrix was replaced by a copper matrix. In this case, a wire of 0.3 mm diameter and 2.3 mm length was obtained, which was encapsulated in a sealed tube 0.4 mm in diameter and 2.5 mm in length. Although being described with respect to the preferred embodiments above, this description is not to be considered limiting in that the skilled worker will appreciate the possibility of several variations of the invention as defined in the appending claims, without departing from its scope.

Claims: Radiation source for brachytherapy in form of a wire comprising a matrix of a ductile bindermaterial and a radioactive and/or activatable material, wherein the radioactive and/or activatable material is used in form of an insoluble compound, said compound differing from said bindermaterial, and is provided in fine divided form and is mixed with the bindermaterial, characterized by said bindermaterial consisting of a metal, or a metal alloy. Radiation source of claim 1, wherein the radioactive material is selected from β-emitters, γ-emitters and/or x-ray emitting materials, and is a nuclear fission product or is activated by nuclear excitation of an activatable material by particles, preferably neutrons, protons or photons, and has a maximum particle energy of β-radiation (E βmax ) of at least 500 keV and/or photon energy of γ- and/or x-ray radiation in the range of 20 to 100 keV. Radiation source of claims 1 or 2, wherein the radioactive material is selected from the group consisting of the group of Sr/Y-90, Tm-170, P-32, Cl-36, Ce-144, Tb-160, Ta-182, TI-204, W/Re-188, Ir-192 and Se-75 and mixtures thereof. Radiation source of claims 1 or 2, wherein the bindermaterial has a low capture cross-section for the method of activation of the activatable material and/or a low attenuation-factor for the emitted radiation. Radiation source of claim 1, wherein the ductile bindermaterial is selected from the group consisting of Al, Ag, Au, Pb, Cd, Ce, Cr, Co, Cu, Fe, Hg, Hf, Bi, In, Mg, Mn, Mo, Nb, Ni, Pd, Pt, Pr, Re, Rh, Sn, Si, Ta, Ti, Tb, Th, V, W, Y, Yb, Zn, Zr or their alloys and mixtures thereof, preferably Ag, Cu, Al, Ti, Ni, amalgams and Woods alloy. Radiation source of claim 5, wherein the ductile binder material comprises a metal alloy selected from the group consisting of aluminium alloys such as Al/Mg, Al/Cu, Al/Cu/Mg, Al/Mg/Si, Al/Cr, Tinal alloy BB, copper alloys such as brass, bronzes, iron alloys such as Fe/Cr, Fe/Ni, Fe/Cr/Ni, Fe/Cr/Al, nickel alloys such as Ni/Ti, Ni/Cr, nitinol, platinum alloys, titanium alloys such as Ti/Al, Ti/Al/V, Ti/Mo, Woods alloy, Inconel, and amalgams. Radiation source of claim 1, wherein the radioactive and/or activatable material is used in form of an oxide, fluoride, titanate, carbonate, cermet or a ceramic. Radiation source of one of the preceding claims having a ratio of length to diameter in the range of ≥ 2:1, preferably 5:1 to 25:1, more preferably 8:1 to 17:1. Radiation source of one of the preceding claims having a length in the range of less than 1 to 25 mm, preferably 1 to 15 mm, more preferably 2.0 to 10 mm and most preferably 2.5 to 5 mm. Radiation source of one of the preceding claims having a diameter in the range of 0.01 to 1 mm, preferably 0.1 to 0.8 mm, more preferably 0.1 to 0.5 mm and most preferably 0.2 to 0.3 mm. Radiation source of claim 1 further comprising a means for containment. Radiation source of claim 11, wherein the means for containment is a capsule or a coating. Radiation source of claims 11 or 12, wherein the means for containment comprises a metal, preferably selected from Fe, V, Ti, Ni, Au, Pt, Cr, Co or their alloys, or C or a radiation resistant plastic material, and their mixtures.

Inventors: FRITZ EBERHARD DR, HUNT DAVE DR, MENUHR HELMUT, FRITZ, EBERHARD, DR., HUNT, DAVE, DR., MENUHR, HELMUT, Fritz, Eberhard, Dr., c/o AEA Technology QSA GmbH, Hunt, Dave, Dr., c/o AEA Technology plc, Menuhr, Helmut, c/o AEA Technology QSA GmbH
Applicants: AEA TECH QSA GMBH, AEA TECHNOLOGY QSA GMBH
Application year: 1999
Main classification: A61N5
IPC codes: A61K51, A61N5, G21G4, A61M36