NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE

Abstract: The present invention relates to a novel flavone derivative, pharmaceutically acceptable salt, hydrate, solvate and isomer thereof which is useful as an inhibitor against Cyclin Dependent Kinase (CDK), a process for preparation thereof, and a composition of anti-cancer agent or agent for treating neurodegenerative disease comprising this compound as an active ingredient.

Description: NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE TECHNICAL FIELD The present invention relates to a novel flavone derivative represented by the following formula (1) : in which Ri, R.3 and R4 each independently represent hydrogen, halogen, hydroxy, alkyl, lower alkoxy, amino or nitro, R.2 represents hydrogen, halogen, hydroxy, lower alkyl, lower B I alkoxy, amino, nitro or -Y-N — wherein A represents amino which may be optionally substituted with alkyl, cycloalkyl, aralkyl, acyl, or aryl which is optionally substituted with one or two substituents selected from the group consisting of halogen, cyano, nitro and amino ; or 1,2,3,4-tetrahydroisoquinoline which may be optionally substituted with halogenoalkylcarbonyl ; or alkyl, aryl, araikyl or heteroaryl each of which may be optionally substituted with one or two substituents selected from the group consisting of alkyl, halogenoalkyl, halogen, dialkylamino, phenyl, nitro, amino, isooxazole, pyridine, carboxy, morpholine, methylpiperazine and cyano, Y represents SO2 or CO, B represents hydrogen or alkyl, R.5 represents hydrogen or hydroxy, and Rό and R7 are substituted at 0-, m- or from each other and each independently represents hydrogen, hydroxy, halogen or lower alkoxy or together represent lower alkylenedioxy, pharmaceutically acceptable salt, hydrate, solvate and isomer thereof which is useful as an inhibitor for Cyclin Dependent Kinase(hereinafter, referred to as "CDK"), In addition, the present invention relates to a process for preparing the flavone derivative of formula (1) and also relates to an anti-cancer agent or an agent for treating neurodegenerative disease characterized by comprising the compound of formula (1) as an active ingredient. BACKGROUND ART Researches on cell division process in molecular level have been extensively performed from the late 1980's through study of division of frog oocytes, analysis several yeast cell growth or characterization of induced mutants by radiation and study of the tumor suppressor Rb. In the 1990's, it is discovered that small molecular cell growth regulator controls cell division process(i.e. growth, differentiation, cytogenesis, aging and apoptosis etc.) through its own regulatory function. These results were very useful for more precise understanding of the pathology of several diseases. A representative example is cancer. In transformation process from normal cells to cancer cells, it was frequently observed that cell growth regulator loses its own function. That is to say, in cancer cells, the cell growth regulator shows an abnormal activity, which is deeply associated with invasion/metastasis which is crucial in the cancerpathology. Particularly, cell cycle deregulation is recognized to be a direct cause of cancer since cancer occurs in experimental animal when overexpression or knock-out of cell growth regulator is induced by using tranformed animal. The cell growth is under positive or negative regulation in the same manner as other biological regulations. The major pathway of cell cycle regulation known up to now is based on CDK activity and as a result of studies on many cancer cells and carcinogenesis mechanisms, it was confirmed that problems of positive or negative regulation on CDK activity result in carcinogenesis in many cases. That is, cancer may occur when positive or negative regulation and timely regulation which is important for cell growth regulation are disrupted. The representative CDKs of mammals are CDK4(Cyclin dependent kinase 4) which shows its activity in mid-Gl phase of cell cycle, CDK2 which shows its activity in mid-Gl and S phases, CDC2(CDK1) which shows its activity in G2-M phase, and so on. It is known that CDK4 and CDK2 activities are regulated by check point of Gl-S cell cycle and CDC2 activity by check point of G2-M. In many cancer cells, abnormalities appear in the regulatory mechanism of CDK4, CDK2 and CDC2(CDK1) and in fact, it was confirmed that induced abnormalities cause cancer in the transformed animal. Therefore, CDK4, CDK2 and CDC2(CDK1) among several kinds of CDKs are suitable as a target of anti-cancer agents. The results of studies on relation between these CDKs and carcinogenesis will be explained in more detail in the following. The relation between the abnormal regulation of CDK4 activity and carcinogenesis is observed in several cancer tissues. The deletion of pl6 and pl5 genes in several kinds of cancer is reported and particularly, overexpression of cyclin DI is observed, which has close relation with the fact that breast cancer has a metastatic property and which suggests that malignant phenotype may be expressed when CDK4 activity is deregulated. Furthermore, it was reported that pl6 knocked-out mouse has such a high carcinogenesis rate as p53 knocked-out mouse, which suggests that malfunction of pl6 on CDK4 regulation is a cause of carcinogenesis. It gives the possibility that pl6 plays a role in the downstream in NIH 3T3 cell with overexpressed ras or src. Reversely it was observed that modified phenotype wherein pl6 or p21 is transformed with ras is repaired into wild phenotype. From these experimental results, deregulation of CDK4 activity may be a cause of carcinogenesis and play a role in maintenance of phenotype of cancer cell. Therefore, CDK4 inhibitors may have anti-cancer effects. It was reported that overexpression of cyclin E is observed in some breast cancers, deeply associated with metastasis of breast cancer, inhibits cell apoptosis under low serum condition and induces anchorage independent growth, and that hyperproliferation (neoplasia) of mammary epithelial cells is observed in transformed animal with overexpressed CDK2 by MMTV promoter, which suggests that CDK2 activity is related with the progress or maintenance of cell transformation and CDK2 inhibitors may also have anti-cancer effects. It is recently discovered that CDK5 among these CDKs may cause neurodegenerative diseases by phosphorylation of tau protein of the brain. Therefore, CDK5 inhibitor may be useful as an agent for treating neurodegenerative diseases(e.g. Alzheimer's disease). CDK2 inhibitors may have inhibitory effects on CDK5 in that CDK2 and CDK5 are homologous in the same family(Ref. : John Leu et al., "Neuronal CDC2-like kinase", TIBS, January 1995, pp33~37). Furthermore, it is discovered that CDC2(CDK1), CDK3, CDK6 and CDK7 play an important role in each phase of cell division. These are classified into CDKs family. In addition, to cyclin DI and E, cyclin A, B, C, D2, D3, D4, F and G are also calssified into the same family. On the basis of the above-mentioned research, efficient inhibitors of these CDKs may be useful as anti-cancer or anti-neurodegenerative agents. Therefore, recently, these inhibitors have been developed. As effective CDK inhibitors developed hitherto, there exists Flavopiridol, compound of the formula (2) which is under clincal trials[Ref. : EP 0,241,003 and 0,336,061]. In addition, a purine derivative of the formula (3) has been recently developed[Ref : WO 97/16447]. However, the CDK inhibitors developed up to now could not have satisfactory effects. So, the present inventors have made widespread and concentrative researches on CDK inhibitors and as a result, found that the above flavone derivative of formula (1) which has a quite different structure from any other known CDK inhibitors inhibits CDKs effectively and finally, complete the present invention. DISCLOSURE OF THE INVENTION The object of the present invention is to provide a novel flavone derivative of formula (1), pharmaceutically acceptable salt, hydrate, solvate and isomer thereof having an inhibitory activity for CDK. Another object of the present invention is to provide a process for preparing the compound of formula (1). Still another object of the present invention is to provide an anti-cancer agent and an agent for treating neurodegenerative disease each of which is characterized by comprising as an active ingredient the compound of formula (1) with a pharmaceutically acceptable carrier. In this specification, CDKs includes all of CDK2, CDK4, CDC2(CDK1), CDK3, CDK5, CDK6, CDK7 etc., and cyclin includes cyclin DI, E, A, B, C, D2, D3, D4, F, and G. DETAILED DESCRIPTION OF THE INVENTION The present invention is explained in detail hereinafter. The present invention relates to a novel flavone derivative represented by the following formula (1) : in which Ri, R3 and R4 each independently represent hydrogen, halogen, hydroxy, alkyl, lower alkoxy, amino or nitro, R2 represents hydrogen, halogen, hydroxy, lower alkyl, lower B l _ alkoxy, amino, nitro or wherein A represents amino which may be optionally substituted with alkyl, cycloalkyl, aralkyl, acyl, or aryl which is optionally substituted with one or two substituents selected from the group consisting of halogen, cyano, nitro and amino ; or 1,2,3,4-tetrahydroisoquinoline which may be optionally substituted with halogenoalkylcarbonyl ; or alkyl, aryl, aralkyl or heteroaryl each of which may be optionally substituted with one or two substituents selected from the group consisting of alkyl, halogenoalkyl, halogen, dialkylamino, phenyl, nitro, amino, isooxazole, pyridine, carboxy, morpholine, methylpiperazine and cyano, Y represents SO2 or CO, B represents hydrogen or alkyl, R5 represents hydrogen or hydroxy, and Rό and R7 are substituted at 0-, m- or /^-position from each other and each independently represents hydrogen, hydroxy, halogen or lower alkoxy or together represent lower alkylenedioxy, pharmaceutically acceptable salt, hydrate, solvate and isomer thereof which has efficacies on treating cancer or neurodegenerative disease through a mechanism of inhibiting CDKs activity, In addition, the present invention relates to a process for preparing the flavone derivative of formula (1) and also relates to an anti-cancer agent or an agent for treating neurodegenerative disease each of which is characterized by comprising the compound of formula (1) as an active ingredient. Among the compound of formula (1) according to the present invention, the preferred compounds include those wherein (1) Ri, R 2 , R 3 and R4 each independently represent hydrogen, halogen, hydroxy, lower alkoxy or nitro(provided that two or more of these four substituents are hydrogen), R 5 represents hydrogen or hydroxy, and Rό and R7 are substituted at o-, m- or />-position from each other and each independently represents hydrogen, hydroxy, halogen or lower alkoxy or together represent lower alkylenedioxy, or (2) Ri represents hydrogen, hydroxy, lower alkoxy or amino, R and R 3 each independently represent hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or amino, R4 represents hydrogen, halogen, hydroxy or lower alkoxy, R 5 represents hydroxy, and Rό and R 7 represent 3 -hydroxy and 4-hydroxy respectively, or (3) Ri, R and R4 each independently represent hydrogen, halogen, hydroxy, alkyl or amino(provided that two or more of these three substituents are hydrogen), B l _ R2 represents A wherein A represents amino which may be optionally substituted with alkyl, cycloalkyl, aralkyl, acyl, or aryl which is optionally substituted with one or two substituents selected from the group consisting of halogen, cyano, nitro and amino ; or 1,2,3,4-tetrahydroisoquinoline which may be optionally substituted with halogenoalkylcarbonyl ; or alkyl, aryl, aralkyl or heteroaryl each of which may be optionally substituted with one or two substituents selected from the group consisting of alkyl, halogenoalkyl, halogen, dialkylamino, phenyl, nitro, amino, isooxazole, pyridine, carboxy, morpholine, methylpiperazine and cyano, Y represents SO2 or CO, B represents hydrogen or alkyl, R5 represents hydroxy, and Rs and R 7 represent 3-hydroxy and 4-hydroxy respectively. More preferred compounds include those wherein (1) Ri, R2, R3 and t each independently represent hydrogen, chloro, hydroxy, methoxy or nitro(provided that two or more of these four substituents are hydrogen), R5 represents hydrogen or hydroxy, and Rό and R 7 are substituted at o-, m- or ^-position from each other and each independently represents hydrogen, hydroxy, chloro or methoxy or together represent methylenedioxy, or (2) Ri represents hydrogen, hydroxy or lower alkoxy, R2 represents hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or amino, R3 represents hydrogen, hydroxy, lower alkyl, lower alkoxy or amino, R4 represents hydrogen, halogen or hydroxy, R5 represents hydroxy, and Rό and R7 represent 3-hydroxy and 4-hydroxy respectively, or (3) Ri, R 3 and R4 each represent hydrogen, B l _ R2 represents wherein A represents amino which may be optionally substituted with cycloalkyl ; or 1,2,3,4-tetrahydroisoquinoline which may be optionally substituted with halogenoalkylcarbonyl ; or alkyl, aryl, aralkyl or heteroaryl each of which may be optionally substituted with one or two substituents selected from the group consisting of alkyl, halogenoalkyl, halogen, dialkylamino, phenyl, nitro, amino, isooxazole, pyridine, carboxy, morpholine and methylpiperazine, Y represents S0 2 , B represents hydrogen, R5 represents hydroxy, and Rδ and R7 represent 3-hydroxy and 4-hydroxy respectively, or (4) Ri, R3 and R4 each represent hydrogen, B l _ R 2 represents wherein A represents amino which may be optionally substituted with cycloalkyl, aralkyl, acyl, or aryl which is optionally substituted with one or two substituents selected from the group consisting of halogen, cyano, nitro and amino ; or alkyl or aryl each of which may be optionally substituted with halogen, Y represents CO, B represents hydrogen, R5 represents hydroxy, and Re and R7 represent 3-hydroxy and 4-hydroxy respectively. Most preferred compounds include those wherein (1) Ri represents hydrogen, hydroxy or methoxy, R 2 represents hydrogen, bromine, hydroxy, methyl or amino, R3 represents hydrogen, hydroxy, methyl, methoxy or amino, Rt represents hydrogen, halogen or hydroxy, R5 represents hydroxy, and Re and R7 represent 3-hydroxy and 4-hydroxy respectively, or (2) Ri, R 3 and R4 each represent hydrogen, B l _ R 2 represents wherein A represents 1,2,3,4-tetrahydroisoquinoline which may be optionally substituted with halogenoalkylcarbonyl ; or aryl or heteroaryl each of which may be optionally substituted with one or two substituents selected from the group consisting of alkyl, halogenoalkyl, halogen, dialkylamino, phenyl, nitro, amino, isooxazole, pyridine, carboxy, morpholine and methylpiperazine, Y represents S0 2 , B represents hydrogen, R 5 represents hydroxy, and Ro and R7 represent 3-hydroxy and 4-hydroxy respectively, or (3) Ri, R3 and R4 each represent hydrogen, B l _ R2 represents wherein A represents amino which is substituted with aryl which is substituted with one or two substituents selected from the group consisting of halogen, cyano, nitro and amino, Y represents CO, B represents hydrogen, R5 represents hydroxy, and Rό and R7 represent 3-hydroxy and 4-hydroxy respectively. Typical examples of the flavone derivative of formula (1) according to the present invention are compound 1) 2-(4-chloro-phenyl)-7-methoxy-chromen-4-one, compound 2) 7-methoxy-2-phenyl-chromen-4-one, compound 3) 7-hydroxy-2-phenyl-chromen-4-one, compound 4) 2-(benzo[l,3]dioxol-5-yl)-3-hydroxy-5-methoxy- chromen-4-one, compound 5) 2-(benzo[l,3]dioxol-5-yl)-3-hydroxy-6-methoxy- chromen-4-one, compound 6) 2-(benzo[l,3]dioxol-5-yl)-3-hydroxy-7-methoxy- chromen-4-one, compound 7) 3-hydroxy-7-methoxy-2-(4-methoxy-phenyl)-chromen- 4-one, compound 8) 2-(4-chloro-phenyl)-3-hydroxy-7-methoxy-chromen-4- one, compound 9) 6-chloro-3-hydroxy-2-(4-methoxy-phenyl)-8-nitro- chromen-4-one, compound 10) 6,8-dichloro-3-hydroxy-2-(4-methoxy-phenyl)- chromen-4-one, compound 11 3-hydroxy-2-(4-methoxy-phenyl)-chromen-4-one, compound 12 6-chloro-2-(3 ,4-dihydroxyphenyl)-3 -hy droxy-4H- chromen-4-one, compound 13 6-bromo-2-(3 ,4-dihydroxyphenyl)-3 -hydroxy-4H- chromen-4-one, compound 14 2-(3 ,4-dihydroxyphenyl)-3 ,6-dihydroxy-4H-chromen- 4-one, compound 15 6-amino-2-(3 ,4-dihydroxyphenyl)-3 -hy droxy-4H- chromen-4-one, compound 16 2-(3 ,4-dihydroxyphenyl)-3 -hydroxy-6-methoxy-4H- chromen-4-one, compound 17 6-fluoro-2-(3 ,4-dihydroxyphenyl)-3 -hy droxy-4H- chromen-4-one, compound 18 6-methyl-2-(3 ,4-dihy droxyphenyl)-3 -hy droxy-4H- chromen-4-one, compound 19 6,8-dichloro-2-(3,4-dihydroxyphenyl)-3-hydroxy-4H- chromen-4-one, compound 20 6,8-dibromo-2-(3,4-dihydroxyphenyl)-3-hydroxy-4H- chromen-4-one, compound 21 6,8-difluoro-2-(3,4-dihydroxyphenyl)-3-hydroxy-4H- chromen-4-one, compound 22) 6-chloro-2-(3,4-dihydroxyphenyl)-3-hydroxy-7- methyl-4H-chromen-4-one, compound 23) 2-(3,4-dihydroxyphenyl)-3-hydroxy-7-methoxy-4H- chromen-4-one, compound 24) 2-(3,4-dihydroxyphenyl)-3,8-dihydroxy-7-methoxy- 4H-chromen-4-one, compound 25) 2-(3,4-dihydroxyphenyl)-3,8-dihydroxy-4H-chromen- 4-one, compound 26) 2-(3,4-dihydroxyphenyl)-6,7-dimethyl-3-hydroxy-4H- chromen-4-one, compound 27) 2-(3,4-dihydroxyphenyl)-3-hydroxy-5-methoxy-4H- chromen-4-one, compound 28) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-4-methylbenzenesulfonamide, compound 29) 4-bromo-N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4- oxo-4H-chromen-6-yl]benzenesulfonamide, compound 30) 3-bromo-N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4- oxo-4H-chromen-6-yl]benzenesulfonamide, compound 31) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-2-naphthalenesulfonamide, compound 32) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-5-(dimethylamino)-l-naphthalenesulfonamide, compound 33) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-2-( 1 -naphthyl)- 1 -ethanesulfonamide, compound 34) 4,5-dibromo-N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4- oxo-4H-chromen-6-yl]-2-thiophenesulfonamide, compound 35) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-[ 1 , l'-biphenyl]-4-sulfonamide, compound 36) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-5-(isooxazolyl)-2-thiophenesulfonamide, compound 37) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-5-(2-pyridinyl)-2-thiophenesulfonamide, compound 38) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-3,4-difluorobenzenesulfonamide, compound 39) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-4-(trifluoromethyl)benzenesulfonamide, compound 40) 4-chloro-N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4- oxo-4H-chromen-6-yl]-3-nitrobenzenesulfonamide, compound 41) 3-chloro-N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4- oxo-4H-chromen-6-yl]-l-propanesulfonamide, compound 42) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-2,4-difluorobenzenesulfonamide, compound 43) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-4-fluorobenzenesulfonamide, compound 44) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-2-(2,2,2-trifluoroacetyl)-l,2,3,4-tetrahydro-7-isoquinolinesulfon amide, compound 45) 4-({[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl] amino } sulfonyl)benzoic acid, compound 46) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-l,2,3,4-tetrahydro-7-isoquinolinesulfonamide, compound 47) N-cyclohexyl-N'-[2-(3,4-dihydroxyphenyl)-3-hydroxy- 4-oxo-4H-chromen-6-yl]-sulfide, compound 48) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-4-(4-morpholinyl)-3-nitrobenzenesulfonamide, compound 49) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-4-(4-methyl-l-piperazinyl)-3-nitrobenzenesulfonamide, compound 50) 3-amino-N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4- oxo-4H-chromen-6-yl]-4-(4-methyl-l-piperazinyl)benzenesulfonamide, compound 51) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl] acetamide, compound 52) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]benzamide, compound 53) 4-chloro-N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4- oxo-4H-chromen-6-yl]benzamide, compound 54) N-benzyl-N'-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4- oxo-4H-chromen-6-yl]urea, compound 55) N-(4-bromophenyl)-N'-[2-(3,4-dihydroxyphenyl)-3- hydroxy-4-oxo-4H-chromen-6-yl]urea, compound 56) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl] -N'-phenylurea, compound 57) N-benzoyl-N'-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4- oxo-4H-chromen-6-yl]urea, compound 58) N-(3-bromophenyl)-N'-[2-(3,4-dihydroxyphenyl)-3- hydroxy-4-oxo-4H-chromen-6-yl]urea, compound 59) N-(2,4-dichlorophenyl)-N'-[2-(3,4-dihydroxyphenyl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-urea, compound 60) N-(3-cyanophenyl)-N'-[2-(3,4-dihydroxyphenyl)-3- hydroxy-4-oxo-4H-chromen-6-yl]urea, compound 61) N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-N'-(4-nitrophenyl)urea, compound 62) N-(4-aminophenyl)-N'-[2-(3,4-dihydroxyphenyl)-3- hydroxy-4-oxo-4H-chromen-6-yl]urea, compound 63) 2-(3,4-dihydroxyphenyl)-3-hydroxy-4H-chromen-4- one, compound 64) 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen- 4-one, compound 65) 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H- chromen-4-one, and compound 66) 2-(3,4-dihydroxyphenyl)-3,7,8-trihydroxy-4H- chromen-4-one. The above compound of formula (1) may also form a pharmaceutically acceptable salt. Such a salt includes non-toxic acid addition salt containing pharmaceutical acceptable anion, for example a salt with inorganic acids such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, hydrobromic acid, hydroiodic acid, etc., a salt with organic carboxylic acids such as tartaric acid, formic acid, citric acid, acetic acid, trichloroacetic acid, trifluoroacetic acid, gluconic acid, benzoic acid, lactic acid, fumaric acid, maleic acid, etc., or a salt with sulfonic acids such as methanesulfonic acid, benzenesulfonic acid, />-toluenesulfonic acid, naphthalenesulfomc acid, etc. The compound of formula (1) may also exist in the form of hydrate or solvate. Since the compounds according to the present invention may have asymmetric carbon centers, they can be present in the form of racemate, diastereomer or mixtures thereof. Therefore, the present invention also includes all these isomers and their mixtures. The compound of the formula (1) according to the present invention may be prepared by process described in the following. First, the compound of formula (1) wherein R5 is hydrogen, namely the compound of the following formula (la) : wherein Ri, R 2 , R3, R4, e and R7 are defined as previously described, or a salt thereof may be prepared characterized by a) cyclizing a compound of the following formula (4) : wherein Ri, R2, R3, R4, Rό and R7 are defined as previously described, in the presence of trifluoroacetic acid to give a compound of the following formula (5) : wherein Ri, R2, R3, Rt, Rό and R7 are defined as previously described, then reducing the resulting compound of formula (5) in the presence of a reducing agent in a solvent or b) cyclizing a compound of the following formula (6) : wherein Ri, R2, R3, R4, Rό and R7 are defined as previously described, in the presence of sodium acetate in a solvent. The processes are depicted in the following Schemes (1) and (2). [Scheme 1] Reduction [Scheme 2] wherein R 1; R 2 , R3, R4, Rό and R7 are defined as previously described. In the reaction depicted in Scheme (1), the compound of formula (5) is prepared from cyclization of the compound of formula (4) during which the compound (4) is heated under reflux in the presence of trifluoroacetic acid. This reaction is carried out for an enough time, usually for a day, to complete the reaction depending on the kind of reactant. After the cyclization is completed, the chromane derivative of formula (5) thus obtained is oxidized with a oxidizing agent in a solvent to produce the chromene derivative of above formula (la). As the solvent, one or more selected from the group consisting of benzene and toluene may be preferably used. As the oxidizing agent, 2,3-dichloro-5,6- dicyano-l,4-benzoquinone (DDQ) is used preferably. In the reaction according to Scheme (2), the compound of formula (la) wherein R 5 is hydrogen is prepared by cyclizing the compound of formula (6) in the presence of sodium acetate in a solvent. At this time, acetic acid is preferably used as the solvent. Second, the compound of formula (1) wherein R5 is hydroxy, namely the compound of following formula (lb) : wherein Ri, R 2 , R3, R4, Rό and R7 are defined as previously described, or a salt thereof may be prepared characterized by cyclizing the compound of following formula (4) : wherein Ri, R , R 3 , R4, Rό and R 7 are defined as previously described, in the presence of a base and hydrogen peroxide in a solvent. Especially, the compound of formula (lb) wherein Rό and R 7 together represent methylenedioxy, namely the compound of formula (lcc) : wherein Ri, R 2 , R 3 and R4 are defined as previously described, can be prepared from the compound of following formula (4a) : wherein Ri, R 2 , R3 and t are defined as previously described, according to the above method. The process of the above reaction is depicted in the following Scheme (3). [Scheme 3] wherein R 1; R 2 , R 3 , Rt, Rό and R7 are defined as previously described. In the reaction according to the Scheme (3), the compound of formula (lb) is prepared by cyclizing compound of formula (4) in the presence of hydrogen peroxide. In this process, a solvent and a base are used. As the solvent, the one which does not adversely affect the reaction, such as for example, one or more selected from the group consisting of methanol and ethanol, particularly methanol is used. The base includes one or more selected from the group consisting of sodium hydroxide and potassium hydroxide. Particularly an aqueous sodium hydroxide solution having a concentration of 10% is preferable. This reaction should be conducted inevitably by using hydrogen peroxide which is used in excess amount, preferably in an amount of 5 to 10 times molar equivalents with respect to the compound of formula (4). Suitably, it is used in an aqueous solution of 30%. The reaction may be promoted by optionally adding acid catalyst, such as hydrochloric acid. The reaction is usually carried out at room temperature or under warming, and about 3 hours are usually required to complete the reaction at room temperature. Deprotection reaction may also be carried out to remove the amino- or hydroxy-protecting group which exists optionally. That is to say, the compound of formula (1) wherein one or more of the substituents Ri, R_, R3 and R4 are hydroxy or amino may be prepared characterized by selectively deprotecting the hydroxy or amino group which is protected by lower alkyl or alkanoyl in the presence of boron tribromide or by hydrolyzing with aqueous sulfuric acid solution or alcohol solvent. Moreover, the compound of formula (1) wherein R 2 is B I A— Y-N- , namely the compound of the following formula (lh) wherein Ri, R3, Rt, R5 and A, Y, B are defined as previously described, may be prepared by reacting the compound of formula (9) : wherein R 1? R 3 , R4, R5 and B are defined as previously described, with the compound of formula (10) : A-Y-X (10) wherein A and Y are defined as previously described and X is a leaving group, or with the compound of formula (11) : A' -N=C=0 (11) wherein A' represents aralkyl, acyl or aryl which is optionally substituted with one or two substituents selected from the group consisting of halogen, cyano and nitro. Especially, the compound of formula (lh) wherein R5 is hydroxy, namely the compound of formula (lhh) : wherein R ls R3, Rt, A, Y and B are defined as previously described, can be prepared from the compound of formula (9a) : wherein R 1; R3, R4 and B are defined as previously described, according to the above method. The compound of formula (9), especially the compound of formula (9a) used in the above method can be prepared by process described in the following. A compound of formula (4b) : wherein Ri, R3, Rx and B are defined as previously described, is prepared by reacting 2-hydroxyacetophenone derivative of formula (7a) : wherein Ri, R 3 , Rt and B are defined as previously described, the piperonal of formula (8a) and sodium hydroxide in the aqueous ethanol solution solvent, then thus obtained compound of formula (4b) is reacted with aqueous sodium hydroxide and hydrogen peroxide in methanol solvent to produce a compound of formula (le) : wherein Ri, R3, R4 and B are defined as previously described. Then, the above obtained compound of formula (le) is hydrolyzed with aqueous sulfuric acid solution in alcoholic solvent to give a compound of formula (9a) wherein Ri, R3, Rt and B are defined as previously described. The compound of formula (1) wherein one to six of the substituents Ri, R2, R3, Rt, Rό and R7 are hydroxy may be prepared characterized by selectively deprotecting one to six lower alkoxy groups or lower alkylenedioxy group in the compound of formula (1) in order to convert them into hydroxy of dihydroxy group in the presence of boron tribromide. For example, the compound of formula (1) wherein R 6 and R 7 represent 3-hydroxy and 4-hydroxy respectively, namely compound of formula (Id) : wherein Ri, R2, R3, Rt, and R5 are defined as previously described, may be prepared from the compound of formula (lc) : wherein Ri, R , R 3 , Rt, and R5 are defined as previously described, according to the reaction as depicted in the following Scheme (4). [Scheme 4] wherein Ri, R2, R3, R4, and R5 are defined as previously described. Especially, the compound formula (Id) wherein R5 is hydroxy, namely the compound of formula (ldd) : wherein Ri, R2, R3 and Rt are defined as previously described, can be prepared from the compound of formula (lcc) : wherein Ri, R 2 , R3 and R4 are defined as previously described, according to the above method. In addition, the compound of formula (lcc) wherein R 2 is B I A— Y-N- namely the compound of formula (li) wherein Rj, R3, Rt, A, Y and B are defined as previously described, can be prepared from the compound of formula (lhh) : wherein Ri, R 3 , Rt, A, Y and B are defined as previously described, according to the above method. In the reaction according to Scheme 4, the compound of formula (Id) is prepared by opening the dioxolane ring of the compound of formula (lc) to convert it into dihydroxy group. The opening of dioxolane ring is accomplished by a reaction with boron tribromide which is usually used in an amount of 2 to 5 equivalents, preferably 3 equivalents or more, with respect to the compound of formula (lc). This opening reaction is preferably carried out in a solvent and as the solvent, one or more selected from the group consisting of methylenechloride, dioxane, benzene and toluene, preferably methylenechloride, may be mentioned. The reaction is usually carried out at room temperature or under warming and the reaction is completed at room temperature for about 2 horns. The compound of formula (4) used as a starting material in the above process for preparation of the compound of formula (1) according to the present invention may be produced by reacting a 2-hydroxyacetophenone derivative of the following formula (7) wherein Ri, R 2 , R3, and Rt are defined as previously described, with a compound of the following formula (8) : wherein Rό and R 7 are defined as previously described, in the presence of a base in a solvent. Especially, the compound of formula (4a) can be prepared by reacting the compound of the formula (7) with piperonal of formula (8a) according to the above method. The above reaction is depicted in the following Scheme (5). [Scheme 5] (7) (8) wherein Ri, R 2 , R3, Rt, Rό and R 7 are defined as previously described. In the reaction according to Scheme 5, the compound of formula (4) is prepared by coupling the 2-hydroxyacetophenone derivative of formula (7) with the compound of formula (8) in an amount of 1 to 3 equivalents, preferably 3 equivalents. As the solvent which can be used, one or more selected from the group consisting of water, methanol, ethanol, propanol, butanol and dioxane may be exemplified, and methanol, ethanol or aqueous ethanol solution(80%) is more preferable. As the base, one or more selected from the group consisting of sodium hydroxide, potassium hydroxide, calcium hydroxide, sodium carbonate, potassium carbonate and calcium carbonate, preferably sodium hydroxide, may be mentioned. The amount of base is not particularly restricted, however it is generally used in an amount of 2 to 5 equivalents, preferably 3 equivalents with respect to the compound of formula (7). The reaction is usually carried out at room temperature or under warming and reaction time is variable according to the kind of used solvent or base used, or reaction temperature. The reaction is usually completed at room temperature for about 15 hours. In the processes as explained in above, the reaction conditions including the amount of reactants, reaction temperature, reaction time, etc. are easily determined depending on the reactants selected by a person having ordinary skill in this art. In general, as for solvent, any one can be used unless it adversely affect the reaction. The reaction temperature may be changeable in variety, however the reaction is preferably carried out at temperatures ranging from 0 to 120°C . The free compound of formula (1) prepared in the reaction according to the present invention may be converted into the above-mentioned salt in a conventional manner well-known in the art. In addition, after the reaction is completed, the product may be isolated or purified by conventional work up procedures such as chromatography, recrystallization, etc. The compound of the present invention prepared according to the above method has an inhibitory activity against CDK, and thus may be put to a good use as an anti-cancer agent. Accordingly, another object of the present invention is to provide an anti-cancer agent or an agent for treating neurodegenerative disease which comprises the compound of formula (1), pharmaceutically acceptable salt, hydrate, solvate or isomer thereof as an active ingredient together with pharmaceutically acceptable carrier. In case the compound of the present invention is administered for clinical purpose, it is preferably administered in an amount ranging from 0.01 to 50mg/kg of body weight a day. The total daily dosage may be administered in one time or over several times. However, the specific dosage for a specific patient can be varied according to the specific compound used, body weight of the subject patient, sex, hygienic condition, diet, time or method of administration, excretion rate, mixing ratio of the medicine, severity of the disease to be treated, etc. The compound of the present invention may be administered in the form of injections or oral preparations. Injections such as sterilized aqueous or oily suspension for injection may be prepared by using suitable dispersing agent, humectant or suspension agent according to the known method. As solvents to be used for preparing injections, water, Ringer's fluid and isotonic NaCl solution can be mentioned, and sterilized fixing oil is also used as the solvent or suspension medium. Any non-stimulative fixing oil including mono- or di-glyceride can be used for this purpose, and also fatty acid such as oleic acid can be used for injection formulation. As the solid preparation for oral administration, capsules, tablets, pills, powders and granules, preferably capsules and tablets can be mentioned. It is desirable for tablets and pills to be formulated into enteric-coated preparation. Solid preparations may be prepared by mixing the active compound of formula (1) according to the present invention with least one carrier selected from a group consisting of inert diluents(e.g. sucrose, lactose, starch, etc.), lubricants(e.g. magnesium stearate), disintegrators, and binders. The present invention is more specifically explained by the following prepartions and examples. However, it should be understood that the present invention is not limited to these examples in any manner. Preparation 1 : Synthesis of l-(3,5-dichloro-2-hydroxy-phenyl) -3-(4-methoxy-phenyl)-propenone l.Og (4.8 mmol) of 3',5'-dichloro-2'-hydroxyacetophenone was dissolved in 30 m £ of methanol solvent, and then 0.53g of NaOH(13.2 mmol) was added thereto. The mixture was stirred for 30 minutes. 0.61g (4.8 mmol) of 4-methoxybenzaldehyde was added thereto, the mixture was heated to 50 °C , and then it was stirred for 3 hours. After the reaction was completed, methanol was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography (eluent : n-hexane/ethylacetate=4/l, v/v) to give the title compound in a yield of 57%. 1H NMR(500MHz, CDC1 3 ): § 8.52(m, IH), 7.60-7.02(m, 5H), 6.22-6.00(m, 2H), 3.90(s, 3H) MS(FAB): 323(M+H + ) Preparation 2 : Synthesis of l-(2-hydroxy-phenyl)-3-(4-methoxy- phenyl)-propenone The title compound was obtained in a yield of 80% according to the same procedure as Preparation 1 using l.Og (7.3 mmol) of 2'-hydroxyacetophenone and 0.99g (7.3 mmol) of 4-methoxybenzaldehyde. 1H NMR(500MHz, CDC1 3 ): § 7.44-6.66(m, 8H), 6.21-6.01(m, 2H), 3.89(s, 3H) MS(FAB): 255(M+H + ) Preparation 3 : Synthesis of 3-(4-chloro-phenyI)-l-(2-hydroxy-4- methoxy-phenyl)-propenone The title compound was obtained in a yield of 77% according to the same procedure as Preparation 1 using l.Og (6.0 mmol) of 2'-hydroxy-4'-methoxy acetophenone and 0.84g (6.0 mmol) of 4-chlorobenzaldehyde. 1H NMR(500MHz, CDCI3): § 7.55-6.46(m, 7H), 6.42-6.2 l(m, 2H), 3.89(s, 3H) MS(FAB): 289(M+H + ) Preparation 4 : Synthesis of 2-(4-chloro-phenyI)-7-methoxy- chroman-4-one O. lg (0.35 mmol) of 3-(4-chloro-phenyl)-l-(2-hydroxy-4-methoxy- phenyl)-propenone synthesized in Preparation 3 was refluxed in solvent of trifluoroacetic acid(TFA) for a day, and TFA was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography (eluent : n-hexane/ethylacetate=5/l, v/v) to give the title compound in a yield of 83%. 1H NMR(500MHz, CDC1 3 ): δ 7.86(d, IH, J=8.7Hz), 7.42(m, 4H), 6.62(d, IH, J=2.4Hz), 6.49(s, IH), 5.45(m, IH), 3.90(s, 3H), 2.98(dd, IH, J=12.7Hz, J=16.6Hz), 2.80(dd, IH, J=12.9Hz, J=16.6Hz) MS(FAB): 289(M+H + ) Preparation 5 : Synthesis of 3-(benzo[l,3]dioxoI-5-yl)-l- (5-chIoro-2-hydroxyphenyI)-2-propen-l-one lg(5.86 mmol) of 5-chloro-2-hydroxyacetophenone, 3 molar equivalents of piperonal, and 3 molar equivalents of sodium hydroxide was mixed in 15m£ of aqueous 80% ethanol solution, and then the mixture was stirred at room temperature for 15 hours. After the reaction was completed, 50 £ of water was added thereto, and the mixture was stirred for about 10 minutes. The obtained pale yellow solid was filtered, washed with water and diethylether, and dried to give 1.42g (Yield 80%) of the title compound. Η NMR (CDC1 3 , ppm); 6 9.80 (IH, br s), 7.84 (IH, s), 7.43 (2H, m), 7.33 (IH, s), 7.19 (IH, m), 6.98 (3H, m), 6.07 (2H, s) FAB MS(m/e) = 303[M + +1] Preparation 6 : Synthesis of 3-(benzo[l,3]dioxol-5-yl)-l-(5- bromo-2-hydroxyphenyl)-2-propen-l-one 1.5g (Yield 93%) of the title compound was obtained according to the same procedme as Preparation 5 except that lg(4.65 mmol) of 5-bromo-2-hydroxyacetophenone was used instead of 5-chloro-2-hydroxy acetophenone. 1H NMR(CDC1 , ppm); δ 7.99 (IH, s), 7.88 (IH, d), 7.55 (IH, d), 7.37(1H, d), 7.21-7.17 (2H, m), 6.94 (IH, d), 6.88 (IH, d) FAB MS (m/e) - 348 [M + +l] Preparation 7 : Synthesis of 3-(benzo[l,3]dioxoI-5-yl)-l-(2- hydroxy-5-methoxyphenyI)-2-propen-l-one 1.3g (Yield 72%) of the title compound was obtained according to the same procedme as Preparation 5 except that lg(6.02 mmol) of 5 -methoxy-2 -hydroxy acetophenone was used instead of 5-chloro-2-hydroxy acetophenone. 1H NMR(CDC1 3 , ppm); δ 7.85 (IH, d), 7.40 (IH, d), 7.33 (IH, s), 7.15 (3H, m), 7.00-6.80 (3H, m), 6.07 (2H, s), 3.84 (3H, s) FAB MS(m/e) = 299[M + +1] Preparation 8 : Synthesis of 3-(benzo[l,3]dioxoI-5-yl)-l-(5- fluoro-2-hydroxyphenyI)-2-propen-l-one 1.6g (Yield 86%) of the title compound was obtained according to the same procedme as Preparation 5 except that lg(6.49 mmol) of 5-fluoro-2-hydroxyacetophenone was used instead of 5-chloro-2-hydroxy acetophenone. Η NMR (CDC1 , ppm); δ 7.85 (IH, s), 7.80 (IH, d), 7.55 (IH, d), 7.37 (IH, d), 7.21-7.17 (2H, m), 6.94 (IH, d), 6.88 (IH, d) FAB MS (m/e) = 287 [M + +l] Preparation 9 : Synthesis of 3-(benzo[l,3]dioxol-5-yl)-l-(5- methy_-2-hydroxyphenyl)-2-propen-l-one 1.7g (Yield 90%) of the title compound was obtained according to the same procedme as Preparation 5 except that lg(6.66 mmol) of 5 -methyl-2-hydroxy acetophenone was used instead of 5-chloro-2-hydroxy acetophenone. 1H NMR (CDC1 3 , ppm); δ 7.73 (IH, s), 7.69 (IH, d), 7.55 (IH, d), 7.37 (IH, d), 7.15-7.25 (2H, m), 6.92(1H, d), 6.85 (IH, d) FAB MS (m/e) =283 [M + +l] Preparation 10 : Synthesis of 3-(benzo[l,3]dioxoI-5-yl)-l-(3,5- dichloro-2-hydroxyphenyl)-2-propen-l-one 1.4g (Yield 85%) of the title compound was obtained according to the same procedure as Preparation 5 except that lg(4.8 mmol) of 3,5-dichloro-2-hydroxyacetophenone was used instead of 5-chloro-2- hydroxy acetophenone . 1H NMR (DMDO-d 6 , ppm); δ 8.57 (IH, br s), 8.11 (IH, s), 8.06 (IH, d), 7.88 (IH, d), 7.78 (IH, s), 7.42 (IH, d), 7.04 (IH, d), 6.13 (2H, s) FAB MS (m/e) = 337 [M + +l] Preparation 11 : Synthesis of 3-(benzo[l,3]dioxoI-5-yI)-l-(3,5- dibromo-2-hydroxyphenyl)-2-propen-l-one 2.9g (Yield 97%) of the title compound was obtained according to the same procedure as Preparation 5 except that 2g(6.8 mmol) of 3,5-dibromo-2-hydroxyacetophenone was used instead of 5-chloro-2- hydroxyacetophenone. 1H NMR (DMDO-dό, ppm); δ 8.57 (IH, br s), 8.08 (IH, s), 8.01 (IH, d), 7.88 (IH, d), 7.78 (IH, s), 7.42 (IH, d), 7.04 (IH, d), 6.13 (2H, s) FAB MS (m/e) = 427 [M + +l] Preparation 12 : Synthesis of 3-(benzo[l,3]dioxol-5-yl)-l-(3,5- difluoro-2-hydroxyphenyl)-2-propen-l-one 1.6g (Yield 90%) of the title compound was obtained according to the same procedure as Preparation 5 except that lg(5.8 mmol) of 3,5-difluoro-2-hydroxyacetophenone was used instead of 5-chloro-2- hydroxy acetophenone . 1H NMR (DMDO-dό, ppm); δ 8.59 (IH, br s), 8.12 (IH, s), 8.01 (IH, d), 7.88 (IH, d), 7.78 (IH, s), 7.42 (IH, d), 7.04 (IH, d), 6.13 (2H, s) FAB MS (m/e) = 305 [M + +l] Preparation 13 : Synthesis of 3-(benzo[l,3]dioxol-5-yl)-l-(5- chloro-2-hydroxy-4-methylphenyl)-2-propen-l-one 0.77g (Yield 90%) of the title compound was obtained according to the same procedure as Preparation 5 except that 0.5g(2.70 mmol) of 4-methyl-5-chloro-2-hydroxyacetophenone was used instead of 5-chloro-2- hydroxy acetophenone . 1H NMR (CDC1 3 , ppm); δ 7.85 (IH, d), 7.82 (IH, s), 7.38 (IH, d), 7.19 (2H, m), 6.86 (2H, m), 6.07 (2H, s), 2.41(3 H, s) FAB MS (m/e) = 317 [M + +l] Preparation 14 : Synthesis of 3-(benzo[l,3]dioxoI-5-yl)-l-(2- hydroxy-4-methoxyphenyl)-2-propen-l-one 1.3g (Yield 72%) of the title compound was obtained according to the same procedure as Preparation 5 except that lg(6.02 mmol) of 4-methoxy-2-hydroxyacetophenone was used instead of 5-chloro-2- hydroxyacetophenone. 1H NMR (CDCI3, ppm); δ 7.85 (IH, d), 7.40 (IH, d), 7.33 (IH, s), 7.15 (3H, m), 7.00-6.80 (3H, m), 6.07 (2H, s), 3.84 (3H, s) FAB MS (m/e) = 299 [M + +l] Preparation 15 : Synthesis of 3-(benzo[l,3]dioxol-5-yl)-l-(2- hydroxy-3,4-dimethoxyphenyl)-2-propen-l-one 1.2g (Yield 72%) of the title compound was obtained according to the same procedure as Preparation 5 except that lg(5.1 mmol) of 3,4-dimethoxy-2-hydroxyacetophenone was used instead of 5-chloro-2- hy droxyacetophenone . 1H NMR (CDCI3, ppm); δ 7.85 (IH, d), 7.40 (IH, d), 7.33 (IH, s), 7.15 (IH, m), 7.00-6.80 (3H, m), 6.07 (2H, s), 3.84 (6H, s) FAB MS (m/e) = 329[M + +1] Preparation 16 : Synthesis of 3-(benzo[l,3]dioxoI-5-yI)-l-(2- hydroxy-3-methoxyphenyl)-2-propen-l-one 1.2g (Yield 67%) of the title compound was obtained according to the same procedure as Preparation 5 except that lg(6.02 mmol) of 3-methoxy-2-hydroxyacetophenone was used instead of 5-chloro-2- hydroxyacetophenone. 1H NMR (CDCI3, ppm); δ 7.85 (IH, d), 7.40 (IH, m), 7.33 (IH, s), 7.15 (2H, m), 7.00-6.80 (3H, m), 6.07 (2H, s), 3.84 (3H, s) FAB MS (m/e) = 299 [M + +l] Preparation 17 : Synthesis of 3-(benzo[l,3]dioxol-5-yl)-l-(2- hydroxy-4,5-dimethylphenyl)-2-propen-l-one 1.77g (Yield 97%) of the title compound was obtained according to the same procedme as Preparation 5 except that lg(6.09 mmol) of 4,5-dimethyl-2-hydroxyacetophenone was used instead of 5-chloro-2- hydroxyacetophenone. 1H NMR (CDCb, ppm); δ 7.75 (IH, s), 7.62 (IH, s), 7.38 (IH, d), 7.19 (2H, m), 6.86 (2H, m), 6.07 (2H, s), 2.41 (6H, s) FAB MS (m/e) = 297 [M + +l] Preparation 18 : Synthesis of 3-(benzo[l,3]dioxoI-5-yl)-l-(2- hydroxy-6-methoxyphenyl)-2-propen-l-one 1.25g (Yield 70%) of the title compound was obtained according to the same procedure as Preparation 5 except that lg(6.02 mmol) of 6-methoxy-2-hydroxyacetophenone was used instead of 5-chloro-2- hydroxy acetophenone . 1H NMR (CDCI3, ppm): δ 7.80-6.71 (m, 6H), 6.22-6.00 (m, 2H), 5.90 (s, 2H), 3.83 (s, 3H) FAB MS (m/e) = 299 [M + +l] Preparation 19 : Synthesis of N-{3-[3-(benzo[l,3]dioxol-5-yl)-2- propenoyI]-4-hydroxyphenyl}acetamide 7.0g (36.23mmol) of 5-acetamido-2-hydroxyacetophenone, 3 molar equivalents of piperonal and 3 molar equivalents (4.32g, 108mmol) of of sodium hydroxide was mixtured in 50ml of aqueous 80% ethanol solution, and then stirred at room temperature for 20 hours. After the reaction was completed, lOOmβ of water was added thereto, and the mixture was further stirred for 10 minutes. The obtained white solid was filtered, washed with water and ethyl ether, and dried to give 9.46g of the title compound in a yield of 80%. 1H NMR(DMSO-d 6 , ppm); δ 11.94(1H, s), 9.86(1H, s), 8.13(1H, s), 7.80-7.67(3H, m), 7.52(1H, s), 7.32(1H, d), 7.03(1H, d), 6.95(1H, d), 6.12(2H, s), 2.02(3H, s) FAB MS (m/e) = 326[M + +1] Example 1 : Synthesis of 2-(4-chloro-phenyl)-7-methoxy- chromen-4-one (compound 1) 50mg (0.17 mmol) of 2-(4-chloro-phenyl)-7-methoxy-chroman-4-one synthesized in Preparation 4 and 3.0 molar equivalents (0.12g, 0.51 mmol) of 2,3-dichloro-5,6-dicyano-l,4-benzoquinone was refuxed in benzene solvent for a day, and then benzene was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography(eluent: n-hexane/ethylacetate=5/l, v/v) to give the title compound in a yield of 79%. Η NMR(500MHz, CDC1 3 ): δ 8.12(d, IH, J=9.3Hz), 7.84(d, 2H, J=8.8Hz), 7.49(d, 2H, 8.8Hz), 7.00(m, 2H), 6.72(s, IH), 3.95(s, 3H) MS(FAB): 287(M+H + ) Example 2 : Synthesis of 7-methoxy-2-phenyl-chromen-4-one (compound 2) 240mg (0.89 mmol) of l-(2-hydroxy-4-methoxy-phenyl)-3-phenyl- propan-l,3-dione was dissolved in acetic acid, and 0.73g(8.9 mmol) of sodium acetate was added thereto. The mixture was refluxed overnight. Acetic acid was removed by distillation under reduced pressure, and then the residue was purified by silica gel column chromatography (eluent : n-hexane/ethylacetate=5/l, v/v) to give the title compound in a yield of 70%. 1H NMR(500MHz, CDC1 3 ): 8.20(m, IH), 7.9 l(m, 2H), 7.55(m, 3H), 6.97(m, 3H), 3.90(s, 3H) MS(FAB): 253(M+H + ) Example 3 : Synthesis of 7-hydroxy-2-phenyl-chromen-4-one (compound 3) lOOmg (0.4 mmol) of compound 7-methoxy-2-phenyl-chromen -4-one obtained in Example 2 was dissolved in methylenechloride, and 2.0 molar equivalents of BBr3 was added thereto. The mixture was stirred for 1 hour. Methanol was added to the mixture, and then solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography (eluent: methylenechloride/methanol=5/95, v/v) to give the title compound in a yield of 64%. 1H NMR(500MHz, αVMeOH): 8.04(m, IH), 7.90(m, 2H), 7.6 l(m, 3H), 6.92(m, 2H), 6.72(m, IH) MS(FAB): 239(M+H + ) Example 4 : Synthesis of 2-(benzo[l,3]dioxol-5-yI)-3-hydroxy-5- methoxy-chromen-4-one(compound 4) 100mg(0.35 mmol) of 3-(benzo[l,3]dioxol-5-yl)-l-(2-hydroxy-6- methoxyphenyl)-propenone obtained in Preparation 18 was dissolved in 5 m£ of methanol, and then 6^ of 10% NaOH and 3.9 m £ of 30% H 2 0 2 was added thereto. The mixture was stirred for 1 horn. 20 m ^ of water was added to the mixture, and then 10 m of 10% HCl was added thereto, and then the mixture was extracted with ethylacetate. The extracted ethylacetate solution was distilled under reduced pressure, and the residue was purified by silica gel column chromatography (eluent : n-hexane/ethylacetate=4/l, v/v) to give the title compound in a yield of 95%. 1H NMR(500MHz, αVMeOH): δ 7.70-6.72(m, 6H), 6.00(s, 2H), 3.92(s, 3H) MS(FAB): 313(M+H + ) Example 5 : Synthesis of 2-(benzo[l,3]dioxol-5-yl)-3-hydroxy-6- methoxy-chromen-4-one (compound 5) The reaction was conducted according to the same procedure as Example 4 except that lOOmg (0.35 mmol) of 3-(benzo[l,3]dioxol-5-yl)-l- (2-hydroxy-5-methoxy-phenyl)-propenone obtained in Preparation 7 was used as a starting material. Then the residue was purified by silica gel column chromatography (eluent: n-hexane/ethylacetate=4/l, v/v) to give the title compound in a yield of 90%. 1H NMR(500MHz, d MeOH): δ 7.56-6.62(m, 6H), 6.08(s, 2H), 3.89(s, 3H) MS(FAB): 313(M+H + ) Example 6 : Synthesis of 2-(benzo[l,3]dioxoI-5-yl)-3-hydroxy-7- methoxy-chromen-4-one (compound 6) The reaction was conducted according to the same procedure as Example 4 except that lOOmg (0.35 mmol) of 3-(benzo[l,3]dioxol-5-yl)-l- (2-hydroxy-4-methoxy-phenyl)-propenone obtained in Preparation 14 was used as a starting material. Then the residue was purified by silica gel column chromatography (eluent: n-hexane/ethylacetate=4/l, v/v) to give the title compound in a yield of 85%. 1H NMR(500MHz, dt-MeOH): δ 7.30-6.79(m, 6H), 6.00(s, 2H), 3.90(s, 3H) MS(FAB): 313(M+H + ) Example 7 : Synthesis of 3-hydroxy-7-methoxy-2-(4-methoxy- phenyl)-chromen-4-one(compound 7) The reaction was conducted according to the same procedure as Example 4 except that 57mg(0.2 mmol) of l-(2-hydroxy-4-methoxy- phenyl)-3-(4-methoxy-phenyl)-propenone was used as a starting material. Then the residue was purified by silica gel column chromatography (eluent: n-hexane/ethylacetate=4/l, v/v) to give the title compound in a yield of 92%. 1H NMR(500MHz, αVMeOH): δ 7.60-6.70(m, 7H), 3.90(s, 3H), 3.87(s, 3H) MS(FAB): 299(M+H + ) Example 8 : Synthesis of 2-(4-chloro-phenyI)-3-hydroxy-7- methoxy-chromen-4-one (compound 8) The reaction was conducted according to the same procedure as Example 4 except that 200mg(0.69 mmol) of 3-(4-chloro-phenyl)-l- (2-hydroxy-4-methoxy-phenyl)-propenone obtained in Preparation 3 was used as a starting material. Then the residue was purified by silica gel column chromatography (eluent: n-hexane/ethylacetate=4/l, v/v) to give the title compound in a yield of 89%. 1H NMR(500MHz, d 4 -MeOH): § 7.50-6.80(m, 7H), 3.92(s, 3H) MS(FAB): 303(M+H + ) Example 9 : Synthesis of 6-chloro-3-hydroxy-2-(4-methoxy- phenyI)-8-nitro-chromen-4-one (compound 9) The reaction was conducted according to the same procedure as Example 4 except that 170 mg(0.51 mmol) of l-(5-chloro-2-hydroxy -3-nitro-phenyl)-3-(4-methoxy-phenyl)-propenone was used as a starting material. Then the residue was purified by silica gel column chromatography (eluent: n-hexane/ethylacetate=2/l, v/v) to give the title compound in a yield of 76%. 1H NMR(500MHz, αVMeOH): δ 8.00(s, IH), 7.67(m, IH), 7.47-6.78(m, 4H), 3.87(s, 3H) MS(FAB): 348(M+H + ) Example 10 : Synthesis of 6,8-dichloro-3-hydroxy-2-(4-methoxy- phenyl)-chromen-4-one (compound 10) The reaction was conducted according to the same procedure as Example 4 except that 150mg(0.47 mmol) of l-(3,5-dichloro-2-hydroxy -phenyl)-3-(4-methoxy-phenyl)-propenone obtained in Preparation 1 was used as a starting material. Then the residue was purified by silica gel column chromatography (eluent: n-hexane/ethylacetate=4/l, v/v) to give the title compound in a yield of 79%. Η NMR(500MHz, dό-DMSO): δ 8.23-7.90(m, 4H), 7.11(m, 2H), 3.87(s, 3H) MS(FAB): 337(M+H + ) Example 11 : Synthesis of 3-hydroxy-2-(4-methoxy-phenyI)- chromen-4-one(compound 11) The reaction was conducted according to the same procedure as Example 4 except that 220mg(0.87 mmol) of l-(2-hydroxy-phenyl)-3- (4-methoxy-phenyl)-propenone obtained in Preparation 2 was used as a starting material. Then the residue was purified by silica gel column chromatography (eluent: n-hexane/ethylacetate=4/l, v/v) to give the title compound in a yield of 91%. 1H NMR(500MHz, d 6 -DMSO): δ 8.20(m, 3H), 7.8 l(m, 2H), 7.45(m, IH), 7.18(m, 2H), 3.91(s, 3H) MS(FAB): 269(M+H + ) Example 12 : Synthesis of 2-(benzo[l,3]dioxol-5-yl)-6-chIoro-3- hydroxy-4H-chromen-4-one lg (3.31 mmol) of the compound obtained in Preparation 5 was dissolved in 5m of methanol, and 2m£ of aqueous 10% sodium hydroxide solution and 2m& of 30% hydrogen peroxide solution were added thereto. Then the mixture was stirred at room temperature for 3 hours. The mixture was diluted with 5mβ of water, and acidified with 4N of hydrochloric acid. Then the resulting product was filtered to give 0.83g (Yield 80%) of the title compound as pale yellow solid. 1H NMR (CDCls, ppm); δ 8.20 (IH, br s), 7.75 (IH, s), 7.70 (IH, d), 7.54 (IH, d), 7.50 (IH, s), 6.99 (2H, m) FAB MS (m/e) = 317 [M + +l] Example 13 : Synthesis of 2-(benzo[l,3]dioxol-5-yl)-6-bromo-3- hydroxy-4H-chromen-4-one 0.89g (Yield 85%) of the title compound was obtained according to the same procedure as Example 12 except that lg (2.89 mmol) of the compound obtained in Preparation 6 was used instead of the compound obtained in Preparation 5. 1H NMR (CDCb+DMSO-dό, ppm); δ 8.47 (IH, s), 8.32 (IH, s), 7.95-7.75 (3H, m), 6.96 (IH, d), 6.07 (2H, s) FAB MS (m/e) = 362 [M + +l] Example 14 : Synthesis of 2-(benzo[l,3]dioxol-5-yI)-6-fluoro-3- hydroxy-4H-chromen-4-one 0.85g (Yield 81%) of the title compound was obtained according to the same procedure as Example 12 except that l.Og (3.48 mmol) of the compound obtained in Preparation 8 was used instead of the compound obtained in Preparation 5. 1H NMR (CDC1 3 , ppm); δ 8.30 (IH, br s), 7.79 (IH, s), 7.70 (IH, d), 7.54 (IH, d), 7.50 (IH, s), 6.99 (2H, m) FAB MS (m/e) = 301 [M + +l] Example 15 : Synthesis of 2-(benzo[l,3]dioxol-5-yl)-6-methyl-3- hydroxy-4H-chromen-4-one 1.3g (Yield 82%) of the title compound was obtained according to the same procedure as Example 12 except that 1.5g (5.3 mmol) of the compound obtained in Preparation 9 was used instead of the compound obtained in Preparation 5. Η NMR (CDCI3, ppm); δ 7.78 (IH, br s), 7.45 (IH, s), 7.40 (IH, d), 7.34 (IH, d), 7.30 (IH, s), 6.99 (2H, m) FAB MS (m/e) = 297 [M + +l] Example 16 : Synthesis of 2-(benzo[l,3]dioxol-5-yl)-6,8-dichIoro- 3-hydroxy-4H-chromen-4-one 1.3g (Yield 89%) of the title compound was obtained according to the same procedme as Example 12 except that 1.4g (4.1 mmol) of the compound obtained in Preparation 10 was used instead of the compound obtained in Preparation 5. 1H NMR (CDC1 3 , ppm); δ 10.00 ( IH, br s), 8.46 (IH, s), 8.20 (IH, s), 7.95 (IH, d), 7.75 (IH, s), 7.53 (I H, d), 6.15 (2H, s) FAB MS (m/e) = 351 [M + +l] Example 17 : Synthesis of 2-(benzo[l,3]dioxoI-5-yl)-6,8-dibromo- 3-hydroxy-4H-chromen-4-one 1.86g (Yield 62%) of the title compound was obtained according to the same procedure as Example 12 except that 2.9g (6.79 mmol) of the compound obtained in Preparation 11 was used instead of the compound obtained in Preparation 5. 1H NMR (CDCb, ppm); δ 10.05 (IH, br s), 8.35 (IH, s), 8.15 (IH, s), 7.90 (IH, d), 7.75 (IH, s), 7.53 (IH, d), 6.15 (2H, s) FAB MS (m/e) = 441 [M + +l] Example 18 : Synthesis of 2-(benzo[l,3]dioxol-5-yl)-6,8-difluoro- 3-hydroxy-4H-chromen-4-one 1.5g (Yield 89%) of the title compound was obtained according to the same procedme as Example 12 except that 1.6g (5.2 mmol) of the compound obtained in Preparation 12 was used instead of the compound obtained in Preparation 5. 1H NMR (CDCb, ppm); δ 10.00 (IH, br s), 8.37 (IH, s), 8.19 (IH, s), 7.91 (IH, d), 7.75 (IH, s), 7.53 (IH, d), 6.15 (2H, s) FAB MS (m/e) = 319 [M + +l] Example 19 : Synthesis of 2-(benzo[l,3]dioxol-5-yl)-6-chloro- 3-hydroxy-7-methy_-4H-chromen-4-one 44mg (Yield 85%) of the title compound was obtained according to the same procedme as Example 12 except that 50mg (157 pmol) of the compound obtained in Preparation 13 was used instead of the compound obtained in Preparation 5. 1H NMR (CDC1 3 , ppm); δ 8.20 (IH, br s), 7.75 (IH, s), 7.70 (IH, d), 7.54 (IH, d), 7.50 (IH, s), 6.99 (2H, m) FAB MS (m/e) = 331 [M + +l] Example 20 : Synthesis of 2-(benzo[l,3]dioxol-5-yl)-3-hydroxy -7,8-dimethoxy-4H-chromen-4-one 80mg (Yield 76%) of the title compound was obtained according to the same procedure as Example 12 except that lOOmg (303 pmol) of the compound obtained in Preparation 15 was used instead of the compound obtained in Preparation 5. 1H NMR (CDCh, ppm); δ 7.87 (IH, d), 7.77 (IH, d), 7.56 (IH, s), 7.51 (IH, m), 6.98 (IH, d), 6.07 (2H, s), 3.92 (6H, s) FAB MS (m/e) = 343 [M + +l] Example 21 : Synthesis of 2-(benzo[l,3]dioxol-5-yI)-3-hydroxy -8-m ethoxy-4H-ch rom en-4-one 80mg (Yield 76%) of the title compound was obtained according to the same procedure as Example 12 except that lOOmg (335 pmol) of the compound obtained in Preparation 16 was used instead of the compound obtained in Preparation 5. 1H NMR (CDCla, ppm); δ 7.87 (IH, d), 7.77 (IH, d), 7.56 (IH, s), 7.51 (IH, m), 7.31-7.26 (2H, m), 6.98 (IH, d), 6.07 (2H, s), 3.92 (3H, s) FAB MS (m/e) = 313 [M + +l] Example 22 : Synthesis of 2-(benzo[l,3]dioxol-5-yl)-3-hydroxy- 6,7-dimethyl-4H-chromen-4-one 95mg (Yield 90%) of the title compound was obtained according to the same procedure as Example 12 except that lOOmg (337 pmol) of the compound obtained in Preparation 17 was used instead of the compound obtained in Preparation 5. 1H NMR (CDCI3, ppm); δ 7.84 (IH, s), 7.37 (2H, m), 7.18 (IH, s), 6.91 (IH, m), 6.07 (2H, s), 2.39 (6H, s) FAB MS (m/e) = 311 [M + +l] Example 23 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yl]acetamide 4g (12.3 mmol) of the compound obtained in Preparation 19 was dissolved in 50m of methanol, and lOm of aqueous 10% sodium hydroxide solution and lOmC of 30% hydrogen peroxide solution were added thereto. Then the mixture was stirred at room temperature for 5 homs. The mixture was diluted with 50m6 of water, and acidified with 4N of hydrochloric acid. Then the resulting product was filtered to give 3.29g (Yield 79%) of the title compound as pale yellow solid. 1H NMR(DMSO-d 6 , ppm) ; δ 10.24(1H, br s), 9.49(1H, br s), 8.40(1H, s), 7.90-7.71(4H, m), 7.12(1H, d), 2.08(3H, s) FAB MS (m/e) = 340[M + +1] Example 24 : Synthesis of 6-amino-2-(benzo[l,3]dioxol-5-yl) -3-hy d roxy-4H-ch rom en-4-one 3g(8.85mmol) of the compound obtained in Example 23 was stirred in 30mβ of aqueous 80% ethanol solution and 10m£ of aqueous 30% sulfuric acid solution at 120 °C for 18 homs. After the reaction was completed, the mixture was cooled to room temperature, and neutralized with cone, ammonia water. Then the obtained solid was filtered, washed with water, and dried to give 1.8g of the title compound in a yield of 68%. 1H NMR(CDC1 3 , ppm); δ 7.85(1H, d), 7.75(1H, s), 7.39(1H, d), 7.08(1 H, d), 6.97(2H, m), 6.05(2H, s), 3.86(2H, br s) FAB MS (m/e) = 298[M + +1] Example 25 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-4-_nethylbenzenesulfonamide 50mg (168pmol) of 6-amino-2-(benzo[l,3]dioxol-5-yl)-3-hydroxy -4H-chromen-4-one obtained in Example 24 was dissolved in 5m£ of methylenechloride, then 2 molar equivalents of 4-toluenesulfonyl chloride (p-TsCl) and 3 molar equivalents of rriethyl amine were added thereto. The mixture was reacted at room temperature for 10 hours. The resulting product was concentrated under reduced pressure, and separated by preparative TLC to give 34mg of the title compound in a yield of 45%. 1H NMR(CDC1 3 , ppm); δ 7.79(2H, d), 7.50-7.20(8H, m), 6.99(1H, d), 6.05(2H, s), 2.47(3H, s). FAB MS (m/e) = 452[M + +1] Example 26 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yI]-4-bromobenzenesulfonamide 100 mg (336 pmol) of 6-amino-2-(benzo[l,3]dioxol-5-yl)-3-hydroxy -4H-chromen-4-one obtained in Example 24 was dissolved in 3m# of pyridine, and the mixture was reacted with 2 molar equivalents of 4-bromobenzenesulfonylchloride at room temperature for 5 hours. After the reaction was completed, the product was diluted with lOrn-d of water, and the obtained solid was filtered. Then the resulting product was washed with water and ethylether, and dried to give 159mg of the title compound in a yield of 91.6%. 1H NMR(MeOH-d4, ppm); δ 8.69(1H, s), 8.11(1H, s), 7.92-7.70(6H, m), 7.58(1H, m), 7.01(1H, d), 6.06(2H, s). FAB MS (m/e) = 517[M + +1] Example 27 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-3-bromobenzenesulfonamide 24mg (Yield 69.4%) of the title compound was obtained according to the same procedme as Example 26 except that 3-bromobenzenesulfonylchloride and 20mg (67 pmol) of 6-amino-2- (benzo[l,3]dioxol-5-yl)-3-hydroxy-4H-chromen-4-one were used instead of 4-bromobenzenesulfonylchloride. 1H NMR(DMSO-d 6 , ppm); δ 10.70(1H, br s), 9.55(1H, s), 7.91(1H, s), 7.85(1H, d), 7.80(1H, d), 7.72(4H, m), 7.50(2H, m), 7.11(1H, d), 6.12(2H, s). FAB MS (m/e) = 517[M + +1] Example 28 : Synthesis of N-[2-(benzo[l,3]dioxoI-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-2-naphthalenesulfonamide 27mg (Yield 82.5%) of the title compound was obtained according to the same procedme as Example 26 except that 2-naphthalenesulfonylchloride was used instead of 4-bromobenzene sulfonylchloride. 1H NMR(DMSO-dό, ppm); δ 10.69(1H, br s), 9.48(1H, s), 8.45(1H, s), 8.15(2H, m), 8.00(1H, d), 7.78-7.55(8H, m), 7.09(1H, d), 6.11(2H, s). FAB MS (m/e) = 488[M + +1] Example 29 : Synthesis of N-[2-(benzo[l,3]dioxoI-5-yI)-3- hydroxy-4-oxo-4H-chromen-6-yl]-5-(dimethylamino)-l-naphthalenesulfon amide 22mg (Yield 61.7%) of the title compound was obtained according to the same procedme as Example 26 except that 5-dimethylamino-l-naphthalenesulfonylchloride(Dansyl chloride) was used instead of 4-bromobenzenesulfonylchloride. 1H NMR(DMSO-dό, ppm); δ 10.97(1H, br s), 9.46(1H, s), 8.44(1H, d), 8.38(1H, d), 8.22(1H, d), 7.75-7.61(6H, m), 7.45(1H, d), 7.26(1H, d), 7.07(1H, d), 6.11(2H, s), 2.79(6H, s). FAB MS (m e) = 531[M + +1] Example 30 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-2-(l-naphthyl)-ethanesulfonamide 32mg (Yield 92.6%) of the title compound was obtained according to the same procedme as Example 26 except that 2-(l-naphthyl)-ethanesulfonylchloride was used instead of 4-bromobenzene sulfonylchloride. 1H NMR(DMSO-d 6 , ppm); δ 10.34(1H, br s), 9.58(1H, s), 7.98(1H, s), 7.90-7.70(7H, m), 7.50-7.40(4H, m), 7.13(1H, d), 6.14(2H, d), 3.47(2H, m), 3.30(2H, m). FAB MS (m/e) = 516[M + +1] Example 31 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yI)-3- hydroxy-4-oxo-4H-chromen-6-yI]-4,5-dibromo-2-thiophenesuIfonamide 33mg (Yield 82%) of the title compound was obtained according to the same procedme as Example 26 except that 4,5-thiophenesulfonyl chloride was used instead of 4-bromobenzene sulfonylchloride. 1H NMR(DMSO-d 6 , ppm); δ 9.60(1 H, s), 7.85-7.74(4H, m), 7.57(2H, m), 7.12(1H, s), 6.16(2H, s). FAB MS (m/e) = 602[M + +1] Example 32 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-[l,l'-biphenyl]-4-sulfonamide 34mg (Yield 98.8%) of the title compound was obtained according to the same procedme as Example 26 except that 4-biphenyl sulfonylchloride was used instead of 4-bromobenzene sulfonylchloride. 1H NMR(DMSO-dό, ppm); δ 10.67(1H, br s), 9.56(1H, s), 8.00-7.47(14H, m), 7.12(1H, d), 6.12(2H, s). FAB MS (m/e) = 514[M + +1] Example 33 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-5-(isooxazolyl)-2-thiophenesulfonamide 30mg (Yield 87.7%) of the title compound was obtained according to the same procedme as Example 26 except that 5-(isooxazolyl)-2-thiophenesulfonylchloride was used instead of 4-bromo b enzene sulfonylchloride . 1H NMR(DMSO-dό, ppm); δ 11.00(1H, br s), 9.58(1H, s), 8.70(1H, s), 7.90-7.50(7H, m), 7.15-7.07(2H, m), 6.13(2H, s). FAB MS (m/e) = 511[M + +1] Example 34 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-5-(2-pyridinyl)-2-thiophenesulfonamide 30mg (Yield 86%) of the title compound was obtained according to the same procedme as Example 26 except that 5-(2-pyridinyl)-2-thiophenesulfonylchloride was used instead of 4-bromo benzenesulfonylchloride. 1H NMR(DMSO-dό, ppm); δ 10.84(1H, br s), 9.56(1H, s), 8.53(1H, s), 8.00-7.70(7H, m), 7.56(2H, m), 7.40(1H, m), 7.11(1H, m), 6.12(2H, s). FAB MS (m/e) = 521[M + +1] Example 35 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-3,4-difluorobenzenesulfonamide 22mg (Yield 69.4%) of the title compound was obtained according to the same procedme as Example 26 except that 3,4-difluorobenzenesulfonylchloride was used instead of 4-bromobenzene sulfonylchloride. 1H NMR(DMSO-d 6 , ppm); δ 10.70(1H, br s), 9.57(1H, s), 7.82-7.52(8H, m), 7.11(1H, d), 6.13(2H, s). FAB MS (m/e) = 474[M + +1] Example 36 : Synthesis of N-[2-(benzo[l,3]dioxoI-5-y_)-3- hydroxy-4-oxo-4H-chromen-6-yl]-4-(trifluoromethyl)benzenesulfonamide 24mg (Yield 70.8%) of the title compound was obtained according to the same procedme as Example 26 except that 4-(trifluoromethyl)benzenesulfonylchloride was used instead of 4-bromo benzenesulfonylchloride. 1H NMR(DMSO-dό, ppm); δ 10.84(1H, br s), 9.57(1H, s), 7.95(4H, m), 7.79-7.71(4H, m), 7.52(1H, d), 7.11(1H, d), 6.13(2H, s). FAB MS (m/e) = 506[M + +1] Example 37 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yI)-3- hydroxy-4-oxo-4H-chromen-6-yl]-4-chloro-3-nitrobenzenesulfonamide 81mg (Yield 93.4%) of the title compound was obtained according to the same procedure as Example 26 except that 4-chloro-3-nitrobenzenesulfonylchloride and 50mg (168 pmol) of 6-amino -2-(benzo[l,3]dioxol-5-yl)-3-hydroxy-4H-chromen-4-one were used instead of 4-bromo benzenesulfonylchloride. 1H NMR(DMSO-dό, ppm); δ 10.90(1H, br s), 9.58(1H, s), 8.42(1H, s), 7.95(2H, m), 7.80-7.70(4H, m), 7.53(1H, d), 7.12(1H, d), 6.12(2H, s). FAB MS (m/e) = 517[M + +1] Example 38 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-3-chloro-l-propanesuIfonamide 61mg (Yield 84.4%) of the title compound was obtained according to the same procedme as Example 37 except that 3 -chloro- 1-propanesulfonylchloride was used instead of 4-chloro-3 -nitro benzenesulfonylchloride. 1H NMR(DMSO-dό, ppm); δ 10.21(1H, br s), 9.58(1H, s), 7.89(1H, s), 7.81(2H, m), 7.75(1H, s), 7.62(1H, d), 7.13(1H, d), 6.13(2H, s), 3.72(2H, m), 3.26(2H, m), 2.12(2H, m). FAB MS (m/e) = 438[M + +1] Example 39 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-2,4-difluorobenzenesulfonamide 76mg (Yield 95.2%) of the title compound was obtained according to the same procedure as Example 37 except that 2,4-difluorobenzenesulfonylchloride was used instead of 4-chloro-3 -nitro benzenesulfonylchloride. 1H NMR(DMSO-d 6 , ppm); δ 10.96(1H, s), 9.54(1H, s), 7.90(1H, m), 7.79-7.70(4H, m), 7.54(2H, m), 7.25(1H, m), 7.11(1H, d), 6.12(2H, s). FAB MS (m/e) = 474[M + +1] Example 40 : Synthesis of N-[2-(benzo[l,3]dioxoI-5-yI)-3- hydroxy-4-oxo-4H-chromen-6-yI]-4-fluorobenzenesulfonamide 72mg (Yield 94%) of the title compound was obtained according to the same procedure as Example 37 except that 4-fluorobenzene sulfonylchloride was used instead of 4-chloro-3-nitrobenzenesulfonyl chloride. 1H NMR(DMSO-dό, ppm); δ 10.59(1H, s), 9.55(1H, s), 7.79-7.71(6H, m), 7.50(1H, d), 7.39(2H, m), 7.12(1H, d), 6.12(2H, s). FAB MS (m/e) = 456[M + +1] Example 41 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-2-(2,2,2-trifluoroacetyl)-l,2,3,4- tetrahydro-7-isoquinolinesuIfonamide 49mg (Yield 82.4%) of the title compound was obtained according to the same procedme as Example 26 except that 2-(2,2,2-trifluoroacetyl)-l,2,3,4-tetrahydro-7-isoquinolinesulfonylchloride and 30mg (101 pmol) of 6-amino-2-(benzo[l,3]dioxol-5-yl)-3-hydroxy-4H- chromen-4-one were used instead of 4-bromobenzene sulfonylchloride. 1H NMR(DMSO-dό, ppm); δ 10.65(1H, br s), 9.54(1H, s), 7.90-7.70(5H, m), 7.60-7.50(2H, m), 7.40(1H, m), 7.11(1H, d), 6.12(2H, s), 4.78(2H, d), 3.76(2H, d), 2.94(2H, m). FAB MS (m/e) = 589[M + +1] Example 42 : Synthesis of 4-({[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yl]amino}suIfonyl)benzoic acid 47mg (Yield 96%) of the title compound was obtained according to the same procedure as Example 41 except that 4-chlorosulfonylbenzoic acid was used instead of 2-(2,2,2-trifluoroacetyl)-l,2,3,4-tetrahydro-7- isoquinolinesulfonylchloride. ] H NMR(DMSO-d 6 , ppm); δ 10.71(1H, br s), 9.55(1H, s), 8.07(2H, d), 7.86-7.70(6H, m), 7.52(1H, d), 7.11(1H, d), 6.12(2H, s). FAB MS (m/e) = 482[M + +1] Example 43 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yI]-l,2,3,4-tetrahydro-7-isoquinoIine sulfonamide 20mg (34 pmol) of the compound obtained in Example 38 was dissolved in methanol, 0.1 m£ of aqueous IN sodium hydroxide solution was added thereto, and the mixtme was stirred at room temperatme for 1 homs. The mixtme was concentrated, diltuted with water, acidified with IN hydrochloric acid, and then neutralized with sodium bicarbonate. The produced solid was filtered, washed with water, and dried to give 14.4mg of the title compound in a yield of 85.8%. 1H NMR(DMSO-dό, ppm); δ 7.76-7.66(4H, m), 7.48(3H, m), 7.23(1H, d), 7.11(1H, d), 6.12(2H, s), 3.85(2H, m), 2.92(2H, m), 2.70(2H, m). FAB MS (m/e) = 493[M + +1] Example 44 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yI)-3- hydroxy-4-oxo-4H-chromen-6-yl]-N'-cyclohexylsulfamide 30mg (101 pmol) of 6-amino-2-(benzo[l,3]dioxol-5-yl)-3-hydroxy -4H-chromen-4-one obtained in Example 24 was dissolved in 3m£ of pyridine, and the mixture was reacted with excess amount of cyclohexylamino sulfonylchloride at room temperature for 15 homs. After the reaction was completed, the resulting product was diluted with 10m£ of water. The produced solid was filtered, washed with water and ethylether, and then dried to give 6mg of the title compound in a yield of 13%. 1H NMR(DMSO-dό, ppm); δ 7.82-7.55(5H, m), 7.13(1H, d), 6.13(2H, s), 3.15(1H, m), 1.67-1.40(4H, m), 1.20-1.05(6H, m). FAB MS (m/e) = 459[M + +1] Example 45 : Synthesis of N-[2-(benzo[l,3]dioxoI-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-4-(4-morpholinyl)-3-nitrobenzene sulfonamide lOmg (19.3 pmol) of the compound obtained in Example 37, excess amount of morpholine and potassium carbonate were introduced into 5 mi of acetonitrile, and boiled for 4 homs. The mixtme was cooled to room temperature, and ethylether was added thereto. The mixtme was stirred for 10 minutes. The produced solid was filtered, washed with water and ethylether, and then dried to give 5mg of the title compound in a yield of 45.5%. 1H NMR(DMSO-d 6 , ppm); δ 10.60(1 H, br s), 9.55(1H, br s), 8.16(1H, s), 7.80-7.70(5H, m), 7.53(1H, d), 7.36(1H, d), 7.11(1H, d), 6.12(2H, s), 3.64(4H, m), 3.10(4H, m). FAB MS (m/e) = 568[M + +1] Example 46 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-4-(4-methyl-l-piperazinyl)-3-nitro benzenesulfonamide 20mg (38.7 pmol) of the compound obtained in Example 37, excess amount of N-methylpiperazine and potassium carbonate were introduced into 5ml of acetonifrile, and boiled for 4 homs. The mixture was cooled to room temperature, concenfrated under reduced pressure, dissolved in 10% methanol/methylenechloride, and then filtered through silica gel pad. The filtrate was concenfrated to give 4.5mg of the title compound in a yield of 20%. Η NMR(DMSO-d 6 , ppm); δ 9.50(1H, br s), 8.13(1H, s), 7.79-7.70C5H, m), 7.52(1H, m), 7.35(1H, d), 7.11(1H, d), 6.12(2H, s), 3.10(4H, m), 2.36(4H, m), 2.17(3 H, s). FAB MS (m/e) = 581[M + +1] Example 47 : Synthesis of N-[2-(benzo[l,3]dioxoI-5-yI)-3- hydroxy-4-oxo-4H-chromen-6-yl]benzamide 30mg (lOlpmol) of 6-amino-2-(benzo[l,3]dioxol-5-yl)-3-hydroxy -4H-chromen-4-one obtained in Example 24 was dissolved in 2ml of methylenechloride, and the mixture was reacted with 10 molar equivalents of benzoylchloride and excess amount of potassium carbonate at room temperatme for 10 homs. The resulting product was filtered, washed with methylenechloride and water, and dried to give 32mg of the title compound in a yield of 79%. Η NMR(DMSO-d 6 , ppm); δ 10.54(1H, s), 9.55(1H, br s), 8.61(1H, s), 8.17(1H, d), 8.02(2H, d), 7.85-7.78(3H, m), 7.62-7.55(2H, m), 7.14(1H, d), 6.14(2H, s) FAB MS (m/e) = 402[M + +1] Example 48 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yI)-3- hydroxy-4-oxo-4H-chromen-6-yl]-4-chlorobenzamide 43.5mg (Yield 99%) of the title compound was obtained according to the same procedure as Example 47 except that 4-chloro benzoylchloride was used instead of benzoylchloride. 1H NMR(DMSO-d 6 , ppm); δ 10.63(1H, br s), 9.61(1H, br s), 8.59(1H, s), 8.15(1H, d), 8.05(2H, d), 8.90-8.70(3H, m), 7.65(2H, d), 7.14(1 H, s), 6.14(2H, s) FAB MS (m/e) = 436[M + +1] Example 49 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yI]-N'-benzy_urea 30mg (lOlpmol) of 6-amino-2-(benzo[l,3]dioxol-5-yl)-3-hydroxy -4H-chromen-4-one and 1.5 molar equivalents of benzylisocyanate were stirred in 3ml of methylenechloride at room temperature for 15 homs. The resulting product was filtered, washed with methylenechloride, and then dried to give 35.9mg of the title compound in a yield of 82.5%. 1H NMR(DMSO-d 6 , ppm); δ 9.40(1 H, br s), 8.96(1H, s), 8.24(1H, s), 7.85-7.65(4H, m), 7.34(2H, m), 7.25(1H, m), 7.12(1H, d), 6.80(1H, m), 6.13(2H, s), 4.33(2H, d). FAB MS (m/e) = 431[M + +1] Example 50 : Synthesis of N-[2-(benzo[l,3]dioxoI-5-yI)-3- hy d roxy-4-oxo-4H-ch rom en-6-y 1]-N '-(4-b rom oph eny l)u rea 34.8mg (Yield 69.6%) of the title compound was obtained according to the same procedme as Example 49 except that 4-bromophenylisocyanate was used instead of benzylisocyanate. Η NMR(DMSO-d 6 , ppm); δ 7.78(1H, d), 7.72(1H, s), 7.55-7.40(4H, m), 7.20-7.05(4H, m), 6.13(2H, s). FAB MS (m/e) = 496[M + +1] Example 51 : Synthesis of N-[2-(benzo[l,3]dioxoI-5-yI)-3- hydroxy-4-oxo-4H-chromen-6-yl]-N'-phenylurea 28.5mg (Yield 67.8%) of the title compound was obtained according to the same procedme as Example 49 except that phenylisocyanate was used instead of benzylisocyanate. 1H NMR(DMSO-dό, ppm); δ 9.10(1H, s), 8.80(1H, s), 8.31(1H, s), 7.84(1H, d), 7.77(1H, s), 7.72(2H, s), 7.49(1H, d), 7.29(2H, m), 7.13(1H, d), 6.98(1H, d), 6.14(2H, s). FAB MS (m/e) = 417[M + +1] Example 52 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yI)-3- hydroxy-4-oxo-4H-chromen-6-yl]-N'-benzoylurea 36mg (Yield 80%) of the title compound was obtained according to the same procedure as Example 49 except that benzoylisocyanate was used instead of benzylisocyanate. Η NMR(DMSO-dό, ppm); δ 11.1(1H, s), 11.0(1H, s), 9.55(1H, s), 8.42(1H, m), 8.04(2H, m), 7.88-7.56(6H, m), 7.13(2H, m), 6.14(2H, s). FAB MS (m/e) = 445[M + +1] Example 53 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yI]-N'-(3-bromophenyl)urea 36mg (Yield 72%) of the title compound was obtained according to the same procedure as Example 49 except that 3-bromophenyl isocyanate was used instead of benzylisocyanate. Η NMR(DMSO-d 6 , ppm); δ 9.50(1H, br s), 9.09(1H, s), 8.97(1H, s), 8.30(1H, s), 7.88(1H, s), 7.82(1H, d), 7.76(1H, s), 7.73(2H, s), 7.34(1H, d), 7.25(1H, t), 7.18(1H, d), 7.12(1H, d), 6.14(1H, s). FAB MS (m/e) = 496[M + +1] Example 54 : Synthesis of N-[2-(benzo[l,3]dioxoI-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-N'-(2,4-dichlorophenyl)urea 39mg (Yield 79.6%) of the title compound was obtained according to the same procedme as Example 49 except that 2,4-dichlorophenylisocyanate was used instead of benzylisocyanate. 1H NMR(DMSO-d 6 , ppm); δ 9.75(1H, s), 9.50(1H, br s), 8.44(1H, s), 8.34(1H, s), 8.23(1H, d), 7.84-7.65(5H, m), 7.42(1H, d), 7.13(1H, d), 6.14(2H, s). FAB MS (m/e) = 486[M + +1] Example 55 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yl)-3- hydroxy-4-oxo-4H-chromen-6-yI]-N'-(3-cyanophenyI)urea 40mg (Yield 89.6%) of the title compound was obtained according to the same procedure as Example 49 except that 3-cyanophenylisocyanate was used instead of benzylisocyanate. 1H NMR(DMSO-d 6 , ppm); δ 9.56(1H, s), 9.15(1H, s), 8.32(1H, s), 8.01(1H, m), 7.84(1H, d), 7.80-7.45(6H, m), 7.14(1H, d), 6.14(2H, s). FAB MS (m/e) = 442[M + +1] Example 56 : Synthesis of N-[2-(benzo[l,3]dioxol-5-yI)-3- hydroxy-4-oxo-4H-chromen-6-yl]-N'-(4-nitrophenyl)urea 37.5mg (Yield 80.5%) of the title compound was obtained according to the same procedme as Example 49 except that 4-nifrophenylisocyanate was used instead of benzylisocyanate. 1H NMR(DMSO-d 6 , ppm); δ 9.57(1H, s), 9.53(1H, s), 8.33(1H, s), 8.21(2H, m), 7.82-7.74(6H, m), 7.13(1H, d), 6.14(2H, s). FAB MS (m/e) = 462[M + +1] Example 57 : Synthesis of 6-chloro-2-(3,4-dihydroxyphenyl)-3- hydroxy-4H-chromen-4-one (compound 12) lOmg (31.6 pmol) of the compound obtained in Example 12 was dissolved in 2m<_ of methylenechloride, 3 molar equivalents of boron tribromide(BBr3) was added thereto, and then the mixtme was stirred at room temperatme for 2 hours. The remained boron fribromide(BBr3) was decomposed with methanol. The residue was concenfrated under reduced pressure, and purified by preparative TLC to give 7mg of the title compound in a yield of 72%. 1H NMR (MeOH-d4, ppm); δ 8.09 (IH, s), 7.80 (IH, s), 7.70 (3H, m), 6.90 (IH, d) FAB MS (m/e) = 305 [M + +l] Example 58 : Synthesis of 6-bromo-2-(3,4-dihydroxyphenyl)-3- hydroxy-4H-chromen-4-one(compound 13) 7.8mg (Yield 16%) of the title compound was obtained according to the same procedme as Example 57 except that 50mg (138 pmol) of the compound obtained in Example 13 was used instead of the compound obtained in Example 12. 1H NMR (MeOH-d4, ppm); δ 8.26 (IH, s), 7.83 (IH, d), 7.80 (IH, s), 7.72 (IH, d), 7.60 (IH, d), 6.91 (IH, d) FAB MS (m/e) = 350[M + +1] Example 59 : Synthesis of 2-(3,4-dihydroxyphenyl)-3,6- dihydroxy-4H-chromen-4-one (compound 14) The reaction was conducted according to the same procedure as Example 57 except that 50mg (159 pmol) of the compound obtained in Example 5 instead of the compound obtained in Example 12 and 5.0 molar equivalents of boron fribromide(BBr3) were used. Then the resulting product was separated by preparative TLC to give 23mg of the title compound in a yield of 51%. 1H NMR (DMSO-dό, ppm); δ 7.47-6.48 (6H, m) FAB MS (m/e) = 287 [M + +l] Example 60 : Synthesis of 6-amino-2-(3,4-dihydroxyphenyl)-3- hydroxy-4H-chromen-4-one (compound 15) The reaction was conducted according to the same procedme as Example 57 except that lOmg (5 pmol) of the compound obtained in Preparation 35 was used instead of the compound obtained in Example 12. The resulting product was concenfrated, and the solid was produced from 10% methanol/methylenechloride solution. The produced solid was filtered to give 9.5mg of the title compound in a yield of 99%. 1H NMR (MeOH- t, ppm); δ 8.1 1 (IH, s), 7.85-7.82 (2H, m), 7.75-7.67 (2H, m), 7.62 (IH, d) FAB MS (m/e) = 286 [M + +l] Example 61 : Synthesis of 2-(3,4-dihydroxyphenyl)-3-hydroxy -6-methoxy-4H-chromen-4-one (compound 16) The reaction was conducted according to the same procedme as Example 57 except that 50mg (159 pmol) of the compound obtained in Example 5 instead of the compound obtained in Example 12 and 1.5 molar equivalents of boron tribromide(BBr3) were used. Then the resulting product was separated by preparative TLC to give 28mg of the title compound in a yield of 60%. Η NMR (MeOH- t, ppm); δ 7.78 (IH, m), 7.65 (IH, m), 7.50 (2H, m), 6.91 (IH, m), 6.80 (IH, m), 3.90 (3H, s) FAB MS (m/e) = 301 [M + +l] Example 62 : Synthesis of 6-fluoro-2-(3,4-dihydroxyphenyI)-3- hydroxy-4H-chromen-4-one(compound 17) 40mg (Yield 83%) of the title compound was obtained according to the same procedure as Example 57 except that 50mg (166 pmol) of the compound obtained in Example 14 was used instead of the compound obtained in Example 12. 1H NMR (MeOH-dt, ppm); δ 8.26 (IH, d), 7.83 (IH, t), 7.80 (IH, s), 7.72 (IH, d), 7.60 (IH, d), 6.91 (IH, d) FAB MS (m/e) = 289 [M + +l] Example 63 : Synthesis of 6-methyI-2-(3,4-dihydroxyphenyl)-3- hydroxy-4H-chromen-4-one (compound 18) 40mg (Yield 83%) of the title compound was obtained according to the same procedme as Example 57 except that 50mg (168 pmol) of the compound obtained in Example 15 was used instead of the compound obtained in Example 12. 1H NMR (MeOH-cU, ppm); δ 8.02 (IH, s), 7.63 (IH, d), 7.80 (IH, s), 7.72 (IH, d), 7.60 (IH, d), 6.91 (IH, d), 2.54 (3H, s) FAB MS (m/e) = 285 [M + +l] Example 64 : Synthesis of 6,8-dichloro-2-(3,4-dihydroxyphenyl) -3-hydroxy-4H-chromen-4-one (compound 19) 20mg (Yield 69%) of the title compound was obtained according to the same procedure as Example 57 except that 30mg (85 pmol) of the compound obtained in Example 16 was used instead of the compound obtained in Example 12. 1H NMR (DMSO-dό, ppm); δ 9.76 (IH, s), 9.72 (IH, s), 9.36 (IH, s), 8.33 (IH, s), 8.15 (IH, s), 7.83 (IH, s), 7.68 (IH, d), 6.93 (IH, d) FAB MS (m/e) = 339 [M + +l] Example 65 : Synthesis of 6,8-dibromo-2-(3,4-dihydroxyphenyl) -3-hydroxy-4H-chromen-4-one (compound 20) 22.8mg (Yield 78%) of the title compound was obtained according to the same procedme as Example 57 except that 30mg (68 pmol) of the compound obtained in Example 17 was used instead of the compound obtained in Example 12. 1H NMR (DMSO-dό, ppm); δ 9.75 (IH, s), 9.69 (IH, s), 9.36 (IH, s), 8.33 (IH, s), 8.15 (IH, s), 7.83 (IH, s), 7.68 (IH, d), 6.93 (IH, d) FAB MS (m/e) = 429 [M + +l] Example 66 : Synthesis of 6,8-difluoro-2-(3,4-dihydroxyphenyl) -3-hydroxy-4H-chromen-4-one (compound 21) 25mg (Yield 86%) of the title compound was obtained according to the same procedme as Example 57 except that 30mg (94 pmol) of the compound obtained in Example 18 was used instead of the compound obtained in Example 12. 1H NMR (DMSO-dό, ppm); δ 9.75 (IH, s), 9.69 (IH, s), 9.36 (IH, s), 8.33 (IH, s), 8.15 (IH, s), 7.83 (IH, s), 7.68 (IH, d), 6.93 (IH, d) FAB MS (m/e) = 307 [M + +l] Example 67 : Synthesis of 6-chloro-2-(3,4-dihydroxyphenyI) -3-hydroxy-7-methyl-4H-chromen-4-one (compound 22) 21.0mg (Yield 73%) of the title compound was obtained according to the same procedure as Example 57 except that 30mg (91 pmol) of the compound obtained in Example 19 was used instead of the compound obtained in Example 12. 1H NMR (MeOH- t, ppm); δ 8.07 (IH, s), 7.79 (IH, s), 7.70 (IH, d), 7.61 (IH, s), 6.90 (IH, d), 2.52 (3H, s) FAB MS (m/e) = 319 [M + +l] Example 68 : Synthesis of 2-(3,4-dihydroxyphenyl)-3-hydroxy -7-methoxy-4H-chromen-4-one (compound 23) The reaction was conducted according to the same procedure as Example 57 except that 50mg (159 pmol) of the compound obtained in Example 6 instead of the compound obtained in Example 12 and 1.5 molar equivalents of boron tiϊbromide(BBr3) were used. Then the resulting product was separated by preparative TLC to give 28mg of the title compound in a yield of 60%. 1H NMR (MeOH-04, ppm); δ 7. IS (IH, m), 7.65 (IH, m), 7.50 (2H, m), 6.91 (IH, m), 6.80 (IH, m), 3.90 (3H, s) FAB MS (m/e) = 301[M + +1] Example 69 : Synthesis of 2-(3,4-dihydroxyphenyl)-3,8- dihydroxy-7-methoxy-4H-chromen-4-one(compound 24) 15mg (Yield 54%) of the title compound was obtained according to the same procedme as Example 57 except that 30mg (87 pmol) of the compound obtained in Example 20 was used instead of the compound obtained in Example 12. Η NMR (MeOH-d4, ppm); δ 8.07 (IH, s), 7.79 (IH, s), 7.70 (IH, d), 7.61 (IH, s), 6.90 (IH, d), 3.84 (3H, s) FAB MS (m/e) = 317 [M + +l] Example 70 : Synthesis of 2-(3,4-dihydroxyphenyl)-3,8- dihydroxy-4H-chromen-4-one (compound 25) 16mg (Yield 58%) of the title compound was obtained according to the same procedure as Example 57 except that 30mg (96 pmol) of the compound obtained in Example 21 was used instead of the compound obtained in Example 12. 1H NMR (MeOH-cU, ppm); δ 8.07 (IH, s), 7.79 (IH, s), 7.70 (IH, d), 7.61 (IH, s), 7.54 (IH, m), 6.90 (IH, d) FAB MS (m/e) = 287 [M + +l] Example 71 : Synthesis of 2-(3,4-dihydroxyphenyI)-6,7- dimethy_-3-hydroxy-4H-chromen-4-one (compound 26) 25mg (Yield 86%) of the title compound was obtained according to the same procedure as Example 57 except that 30mg (96 pmol) of the compound obtained in Example 22 was used instead of the compound obtained in Example 12. 1H NMR (MeOH-d4, ppm); δ 8.07 (IH, s), 7.79 (IH, s), 7.70 (IH, d), 7.61 (IH, s), 6.90 (IH, d), 2.52 (6H, s) FAB MS (m/e) = 299 [M + +l] Example 72 : Synthesis of 2-(3,4-dihydroxyphenyl)-3-hydroxy -5-methoxy-4H-chromen-4-one (compound 27) The reaction was conducted according to the same procedme as Example 57 except that 60mg (190 pmol) of the compound obtained in Example 4 instead of the compound obtained in Example 12 and 1.5 molar equivalents of boron tribromide(BBr3) were used. Then the resulting product was separated by preparative TLC to give 23mg of the title compound in a yield of 40%. 1H NMR(d 6 -DMSO, ppm): δ 7.71-6.47(m, 6H), 3.91(s, 3H) FAB MS (m/e) = 301[M + +1] Example 73 : Synthesis of N-[2-(3,4-dihydroxyphenyl)-3-hydroxy -4-oxo-4H-chromen-6-yl]-4-methylbenzenesulfonamide (compound 28) 20mg (44.3 pmol) of the compound obtained in Example 25 was reacted with excess amount of boron fribromide(BBr3) in 3n_(_ of methylene chloride at room temperature for 3 hours. After the reaction was completed, the resulting product was concenfrated under reduced pressure, and then was separated by preparative TLC using 10% methanol/ methylenechloride solvent to give 2.8mg of the title compound in a yield of 14.3%. 1H NMR(MeOH-d4, ppm); δ 7.75-7.48(7H, m), 7.21(2H, d), 6.90(1H, d), 2.32(3 H, s). FAB MS (m/e) = 440[M + +1] Example 74 : Synthesis of 4-bromo-N-[2-(3,4-dihydroxyphenyl)- 3-hydroxy-4-oxo-4H-chromen-6-yl]benzenesulfonamide (compound 29) 14mg (Yield 71.5%) of the title compound was obtained according to the same procedure as Example 73 except that 20mg (38.7 pmol) of the compound obtained in Example 26 was used instead of the compound obtained in Example 25. 1H NMR(DMSO-dό, ppm); δ 7.73(2H, m), 7.57(3H, m), 7.46(2H, m), 6.89(2H, m). FAB MS (m e) = 505[M + +1] Example 75 : Synthesis of 3-bromo-N-[2-(3,4-dihydroxyphenyl)- 3-hydroxy-4-oxo-4H-chromen-6-yI]benzenesuIfonamide (compound 30) 16mg (Yield 54.5%) of the title compound was obtained according to the same procedure as Example 73 using 30mg (58.1 pmol) of the compound obtained in Example 27. 1H NMR(MeOH-dt, ppm); 5 7.92(1H, s), 7.78-7.67(5H, m), 7.59(1H, m), 7.54(1H, m), 7.39(1H, m), 6.89(1H, d). FAB MS (m/e) = 517[M + +1] Example 76 : Synthesis of N-[2-(3,4-dihydroxyphenyI)-3- hydroxy-4-oxo-4H-chromen-6-yI]-2-naphthaIenesulfonamide (compound 31) l lmg (Yield 41.7%) of the title compound was obtained according to the same procedme as Example 73 using 27mg (55.4 pmol) of the compound obtained in Example 28. Η NMR(MeOH-d 4 , ppm); δ 8.37(1H, s), 7.96-7.53(1 IH, m), 6.87(1H, d). FAB MS (m/e) = 476[M + +1] Example 77 : Synthesis of N-[2-(3,4-dihydroxyphenyl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-5-(dimethylamino)-l-naphthalenesulfon amide (compound 32) l lmg (Yield 51%) of the title compound was obtained according to the same procedure as Example 73 using 22mg (41.5 pmol) of the compound obtained in Example 29. Η NMR(MeOH-d 4 , ppm); δ 8.49(1H, d), 8.42(1H, d), 8.24(1H, d), 7.73-7.59(4H, m), 7.47-7.41(3H, m), 7.25(1H, d), 6.86(1H, d), 2.81(6H, s). FAB MS (m/e) = 19[M + +1] Example 78 : Synthesis of N-[2-(3,4-dihydroxyphenyI)-3- hydroxy-4-oxo-4H-chromen-6-yl]-2-(l-naphthyl)-l-ethanesulfonamide (compound 33) 9mg (Yield 28.8%) of the title compound was obtained according to the same procedure as Example 73 using 32mg (62 pmol) of the compound obtained in Example 30. Η NMR(MeOH-d4, ppm); δ 7.96(1H, s), 7.81-7.71(5H, m), 7.61(2H, s), 7.36(4H, m), 6.91(1H, d), 3.55-3.50(4H, m). FAB MS (m/e) = 504[M + +1] Example 79 : Synthesis of 4,5-dibromo-N-[2-(3,4-dihydroxy phenyl)-3-hydroxy-4-oxo-4H-chromen-6-yI]-2-thiophenesulfonamide (compound 34) lOmg (Yield 50.9%) of the title compound was obtained according to the same procedme as Example 73 using 20mg (33.2 pmol) of the compound obtained in Example 31. 1H NMR(DMSO-d 6 , ppm); δ 11.00(1H, br s), 9.40(1H, br s), 7.79(1H, s), 7.71(2H, m), 7.59-7.53(3H, m), 6.89(1H, d). FAB MS (m/e) = 590[M + +1] Example 80 : Synthesis of N-[2-(3,4-dihydroxyphenyl)-3-hydroxy -4-oxo-4H-chromen-6-yl]-[l,l'-biphenyl]-4-sulfonamide (compound 35) 7.2mg (Yield 21%) of the title compound was obtained according to the same procedure as Example 73 using 35mg (68.2 pmol) of the compound obtained in Example 32. 1H NMR(DMSO-d6, ppm); δ 10.63(1H, br s), 9.60(1H, br s), 9.28(2H, br s), 7.84-7.40(14H, m), 6.87(1H, d). FAB MS (m/e) = 502[M + +1] Example 81 : Synthesis of N-[2-(3,4-dihydroxyphenyI)-3-hydroxy -4-oxo-4H-chromen-6-yl]-5-(isooxazoly_)-2-thiophenesulfonamide (compound 36) 18.7mg (Yield 66%) of the title compound was obtained according to the same procedme as Example 73 using 29mg (56.8 pmol) of the compound obtained in Example 33. 1H NMR(DMSO-d 6 , ppm); δ 10.93(1H, br s), 9.58(1H, br s), 9.32(1H, br s), 8.70(1H, s), 7.84(1H, s), 7.68(3H, m), 7.60-7.50(3H, m), 7.07(1H, s), 6.88(1H, d). FAB MS (m/e) = 499[M + +1] Example 82 : Synthesis of N-[2-(3,4-dihydroxyphenyl)-3-hydroxy -4-oxo-4H-chromen-6-yl]-5-(2-pyridinyl)-2-thiophenesulfonamide (compound 37) 29mg (Yield 99%) of the title compound was obtained according to the same procedure as Example 73 using 30mg (57.6 pmol) of the compound obtained in Example 34. 1H NMR(DMSO-d 6 , ppm); δ 10.80(1H, s), 8.53(1H, d), 7.98(1H, d), 7.87(2H, m), 7.77(1H, d), 7.69(2H, m), 7.55(3H, m), 7.38(1H, m), 6.88(1H, m). FAB MS (m/e) = 509[M + +1] Example 83 : Synthesis of N-[2-(3,4-dihydroxyphenyl)-3-hydroxy -4-oxo-4H-chromen-6-yI]-3,4-difluorobenzenesulfonamide (compound 38) 11.4mg (Yield 53.1%) of the title compound was obtained according to the same procedure as Example 73 using 22mg (46.5 pmol) of the compound obtained in Example 35. Η NMR(DMSO-d 6 , ppm); δ 10.65(1H, s), 9.58(1H, s), 9.31(1H, s), 9.29(1H, s), 7.82(1H, t), 7.72-7.50(7H, m), 6.88(1H, d). FAB MS (m/e) = 462[M + +1] Example 84 : Synthesis of N-[2-(3,4-dihydroxyphenyl)-3-hydroxy -4-oxo-4H-chromen-6-yI]-4-(trifluoromethyl)benzenesulfonamide (compound 39) lOmg (Yield 85.5%) of the title compound was obtained according to the same procedme as Example 73 using 12mg (23.7 pmol) of the compound obtained in Example 36. 1H NMR(DMSO-dό, ppm); δ 10.78(1H, s), 7.95(4H, m), 7.73-7.50(5H, m), 6.88(1H, d). FAB MS (m/e) = 494[M + +1] Example 85 : Synthesis of 4-chloro-N-[2-(3,4-dihydroxyphenyl) -3-hydroxy-4-oxo-4H-chromen-6-yI]-3-nitrobenzenesulfonamide (compound 40) 19mg (Yield 97.3%) of the title compound was obtained according to the same procedure as Example 73 using 20mg (38.7 pmol) of the compound obtained in Example 37. 1H NMR(DMSO-dό, ppm); δ 10.84(1H, s), 9.60(1H, br s), 9.35(1H, s), 9.30(1H, br s), 8.41(1H, s), 7.96(2H, m), 7.74-7.66(3H, m), 7.56-7.50(2H, m), 6.89(1H, d). FAB MS (m/e) = 505[M + +1] Example 86 : Synthesis of 3-chloro-N-[2-(3,4-dihydroxyphenyI) -3-hydroxy-4-oxo-4H-chromen-6-yl]-l-propanesuIfonamide(compound 41) 19mg (Yield 97.8%) of the title compound was obtained according to the same procedme as Example 73 using 20mg (45.7 pmol) of the compound obtained in Example 38. 1H NMR(DMSO-dό, ppm); δ 10.20(1H, s), 9.30(1H, br s), 7.89(1H, s), 7.72(2H, m), 7.59(2H, m), 6.90(1H, d), 3.71(2H, m), 3.26(2H, m), 2.12(2H, m). FAB MS (m/e) = 426[M + +1] Example 87 : Synthesis of N-[2-(3,4-dihydroxyphenyl)-3- hydroxy-4-oxo-4H-chromen-6-yI]-2,4-difluorobenzenesulfonamide (compound 42) 9.4mg (Yield 48.6%) of the title compound was obtained according to the same procedure as Example 73 using 20mg (42 pmol) of the compound obtained in Example 39. 1H NMR(DMSO-dό, ppm); δ 10.94(1H, s), 9.30(1H, br s), 7.90(1H, m), 7.74(1H, m), 7.68(2H, m), 7.54(3H, m), 7.25(1H, m), 6.88(1H, d). FAB MS (m/e) = 462[M + +1] Example 88 : Synthesis of N-[2-(3,4-dihydroxyphenyl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-4-fluorobenzenesulfonamide (compound 43) 5.2mg (Yield 26.5%) of the title compound was obtained according to the same procedure as Example 73 using 20mg (44 pmol) of the compound obtained in Example 40. 1H NMR(DMSO-dό, ppm); δ 10.57(1H, br s), 9.60(1H, br s), 9.30(1H, br s), 7.79(2H, m), 7.72(3H, m), 7.50(2H, m), 7.41(2H, m), 6.88(1H, d). FAB MS (m/e) = 444[M + +1] Example 89 : Synthesis of N-[2-(3,4-dihydroxyphenyl)-3-hydroxy -4-oxo-4H-chromen-6-yl]-2-(2,2,2-trifluoroacetyl)-l,2,3,4-tetrahydro-7- isoquinolinesulfonamide (compound 44) 3.5mg (Yield 17.6%) of the title compound was obtained according to the same procedure as Example 73 using 20mg (34 pmol) of the compound obtained in Example 41. 1H NMR(DMSO-d 6 , ppm); δ 9.70-9.00(4H, br m), 7.74-7.20(8H, m), 6.88(1H, d), 4.30(2H, m), 3.80(2H, m), 3.01(2H, m). FAB MS (m/e) = 577[M + +1] Example 90 : Synthesis of 4-({[2-(3,4-dihydroxyphenyI)-3- hydroxy-4-oxo-4H-chromen-6-yl]amino}sulfonyl)benzoic acid (compound 45) 9.6mg (Yield 49%) of the title compound was obtained according to the same procedure as Example 73 using 20mg (41.5 pmol) of the compound obtained in Example 42. 1H NMR(DMSO-dό, ppm); 5 10.56(1H, s), 9.30(1H, br s), 8.10-7.50(9H, m), 6.89(1H, m). FAB MS (m/e) = 470[M + +1] Example 91 : Synthesis of N-[2-(3,4-dihydroxyphenyl)-3-hydroxy -4-oxo-4H-chromen-6-yl]-l,2,3,4-tetrahydro-7-isoquinoIinesulfonamide (compound 46) 7.8mg (Yield 55.6%) of the title compound was obtained according to the same procedure as Example 73 using 14.4mg (29.2 pmol) of the compound obtained in Example 43. 1H NMR(DMSO-d 6 , ppm); δ 10.64(1H, s), 9.63(1H, s), 9.29(1H, br s), 9.0(1H, m), 7.74-7.40(8H, m), 6.89(1H, d), 4.30(2H, m), 3.47(2H, m), 3.00(2H, m). FAB MS (m/e) = 481[M + +1] Example 92 : Synthesis of N-cyclohexyl-N'-[2-(3,4-dihydroxy phenyI)-3-hydroxy-4-oxo-4H-chromen-6-yl]su_famide (compound 47) 1.5mg (Yield 25.8%) of the title compound was obtained according to the same procedme as Example 73 using 6mg (13 pmol) of the compound obtained in Example 44. 1H NMR(MeOH-04, ppm); δ 7.89-7.50(5H, m), 6.91(1H, d), 3.15(1H, m), 1.79-1.16(10H, m). FAB MS (m/e) = 447[M + +1] Example 93 : Synthesis of N-[2-(3,4-dihydroxyphenyl)-3-hydroxy -4-oxo-4H-chromen-6-yl]-4-(4-morpholinyl)-3-nitrobenzenesuIfonamide (compound 48) 5mg (Yield 25.5%) of the title compound was obtained according to the same procedure as Example 73 using 20mg (35.2 pmol) of the compound obtained in Example 45. 1H NMR(MeOH-d4, ppm); δ 7.92(1H, s), 7.53(3H, m), 7.45(1H, d), 7.36(2H, m), 7.01(1H, d), 6.65(1H, d), 3.49(4H, m), 2.90(4H, m). FAB MS (m/e) = 556[M + +1] Example 94 : Synthesis of N-[2-(3,4-dihydroxyphenyl)-3-hydroxy -4-oxo-4H-chromen-6-yI]-4-(4-methyI-l-piperazinyl)-3-nitrobenzenesuIfon amide (compound 49) 22.5mg (Yield 76.5%) of the title compound was obtained according to the same procedme as Example 73 using 30mg (51.7 pmol) of the compound obtained in Example 46. 1H NMR(MeOH-d4, ppm); δ 8.30(1H, s), 7.90(1H, m), 7.78(2H, m), 7.69(1H, d), 7.60(2H, m), 7.40(1H, m), 6.89(1H, d), 3.57(4H, m), 3.40(4H, m), 2.94(3H, s). FAB MS (m/e) = 569[M + +1] Example 95 : Synthesis of 3-amino-N-[2-(3,4-dihydroxyphenyI) -3-hydroxy-4-oxo-4H-chromen-6-yl]-4-(4-methyl-l-piperazinyl)benzene sulfonamide (compound 50) lOmg (17.6 pmol) of the compound obtained in Example 94 was dissolved in 5mβ of methanol, catalytic amount of 10% Pd/C was added thereto, and the mixtme was reacted under latin of hydrogen gas at room temperature for 3 hours. The resulting product was filtered through celite pad, and washed with methanol. The filtrate was concenfrated, and dried to give 6.4mg of the title compound in a yield of 67.5%. Η NMR(MeOH-d 4 , ppm); δ 7.77(2H, d), 7.69(1H, d), 7.55(2H, m), 7.17(1H, s), 7.06(1H, d), 7.01(1H, d), 6.89(1H, d), 3.34(8H, m), 2.85(3H, s). FAB MS (m/e) = 539[M + +1] Example 96 : Synthesis of N-[2-(3,4-dihydroxyphenyl)-3- hydroxy-4-oxo-4H-chromen-6-yI]acetamide (compound 51) 20mg (59pmol) of the compound obtained in Example 23 was dissolved in 2nd of methylenechloride, and the mixture was reacted with excess amount of boron tribromide(BBr3) at room temperature for 3 homs. The resuting product was concenfrated. Then the produced solid was washed with methylenechloride and 10% methanol/methylenechloride, filtered, and dried to give 18mg of the title compound in a yield of 93%. 1H NMR(MeOH-d4, ppm); δ 8.32(1H, s), 7.94(1H, d), 7.80(1H, s), 7.72(1H, d), 7.69(1H, d), 6.91(1H, d), 2.16(3H, s). FAB MS (m/e) = 328[M + +1] Example 97 : Synthesis of N-[2-(3,4-dihydroxyphenyl)-3-hydroxy -4-oxo-4H-chromen-6-yl]benzamide (compound 52) 24.8mg (Yield 85%) of the title compound was obtained according to the same procedure as Example 96 except that 30mg (74.8 pmol) of the compound obtained in Example 47 was used instead of the compound obtained in Example 23. 1H NMR(MeOH-θ4+DMSO-dό, ppm); δ 11.07(1 H, s), 9.25(1H, s), 8.80(1H, d), 8.69(2H, d), 8.51(1H, s), 8.39(2H, m), 8.30-8.20(3H, m), 7.63(1H, d). FAB MS (m/e) = 390[M + +1] Example 98 : Synthesis of 4-chloro-N-[2-(3,4-dihydroxyphenyl)- 3-hydroxy-4-oxo-4H-chromen-6-yI]benzamide (compound 53) 13mg (Yield 66.7%) of the title compound was obtained according to the same procedme as Example 96 except that 20mg (46 pmol) of the compound obtained in Example 48 was used instead of the compound obtained in Example 23. Η NMR(DMSO-d 6 , ppm); δ 10.59(1H, s), 9.25(1H, br s), 8.57(1H, s), 8.16(1H, d), 8.05(2H, d), 7.75(2H, m), 7.65(1H, d), 7.63(1H, d), 6.91(1H, d). FAB MS (m/e) = 424[M + +1] Example 99 : Synthesis of N-benzy_-N'-[2-(3,4-dihydroxyphenyI) -3-hydroxy-4-oxo-4H-chromen-6-yl]urea (compound 54) 30mg (69.7 pmol) of the compound obtained in Example 49 was introduced into 3mβ of methylenechloride, and the mixture was reacted with 3 molar equivalents of boron tribromide(BBr3) at room temperature for 3 homs. The remained boron tribromide(BBr3) was decomposed with methanol, and the residue was concenfrated under reduced pressure. The produced solid was washed with methylenechloride and 10% methanol/ methylenechloride, filtered, and then dried to give 23mg of the title compound in a yield of 78.9%. 1H NMR(MeOH-d4, ppm); δ 8.83(1H, s), 8.50(3H, m), 8.38(1H, d), 8.29(1H, d), 8.04(4H, m), 7.61(1H, d). FAB MS (m/e) = 419[M + +1] Example 100 : Synthesis of N-(4-bromophenyl)-N'-[2-(3,4- dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]urea (compound 55) 18mg (Yield 92.5%) of the title compound was obtained according to the same procedure as Example 99 except that 20mg (40 pmol) of the compound obtained in Example 50 was used instead of the compound obtained in Example 49. 1H NMR(DMSO-dό, ppm); δ 7.73(2H, m), 7.57(3H, m), 7.46(2H, m), 7.30(1H, m), 6.89(2H, m). FAB MS (m/e) = 484[M + +1] Example 101 : Synthesis of N-[2-(3,4-dihydroxyphenyl)-3- hydroxy-4-oxo-4H-chromen-6-y!]-N'-phenylurea (compound 56) 15mg (Yield 81%) of the title compound was obtained according to the same procedme as Example 99 except that 19mg (45.6 pmol) of the compound obtained in Example 51 was used instead of the compound obtained in Example 49. Η NMR(MeOH-d4, ppm); 5 8.13(1H, s), 7.91(1H, d), 7.81(1H, s), 7.72(1H, m), 7.62(1H, s), 7.45(2H, d), 7.29(2H, m), 7.04(1H, m), 6.91(1H, m). FAB MS (m/e) = 405[M + +1] Example 102 : Synthesis of N-benzoyl-N'-[2-(3,4-dihydroxy phenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]urea (compound 57) 18mg (Yield 77%) of the title compound was obtained according to the same procedure as Example 99 except that 24mg (54 pmol) of the compound obtained in Example 52 was used instead of the compound obtained in Example 49. 1H NMR(DMSO-dό, ppm); δ 11.14(1H, s), 11.02(1H, s), 8.40(1H, s), 8.05(1H, d), 7.90(1H, d), 7.75-7.54(6H, m), 6.91(1H, d). FAB MS (m/e) = 433[M + +1] Example 103 : Synthesis of N-(3-bromophenyl)-N'-[2-(3,4- dihydroxyphenyI)-3-hydroxy-4-oxo-4H-chromen-6-yl]urea (compound 58) 20mg (Yield 85.5%) of the title compound was obtained according to the same procedure as Example 99 except that 24mg (48.4 pmol) of the compound obtained in Example 53 was used instead of the compound obtained in Example 49. 1H NMR(MeOH-d4, ppm); δ 8.14(1H, s), 7.92(1H, d), 7.81(2H, m), 7.13(1H, d), 7.64(1H, d), 7.36(1H, d), 7.20-7.17(2H, m), 6.91(1H, d). FAB MS (m e) = 484[M + +1] Example 104 : Synthesis of N-(2,4-dichloropheny_)-N'-[2-(3,4- dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]urea (compound 59) 25mg (Yield 98.5%) of the title compound was obtained according to the same procedure as Example 99 except that 26mg (53.6 pmol) of the compound obtained in Example 54 was used instead of the compound obtained in Example 49. 1H NMR(MeOH-d 4 , ppm); δ 8.20 (2H, m), 7.90(1H, d), 7.81(1H, s), 7.73(1H, d), 7.65(1H, d), 7.48(1H, s), 7.32(1H, d), 6.91(1H, d). FAB MS (m/e) = 474[M + +1] Example 105 : Synthesis of N-(3-cyanophenyl)-N'-[2-(3,4- dihydroxyphenyI)-3-hydroxy-4-oxo-4H-chromen-6-yl]urea (compound 60) 4.9mg (Yield 50.4%) of the title compound was obtained according to the same procedure as Example 99 except that lOmg (22.6 pmol) of the compound obtained in Example 55 was used instead of the compound obtained in Example 49. 1H NMR(DMSO-d 6 , ppm); 5 9.19(1H, s), 9.13(1H, s), 8.82(1H, s), 8.31(1H, s), 8.01(1H, s), 7.93(1H, s), 7.89(1H, s), 7.74-7.34(7H, m), 6.90(1H, s). FAB MS (m/e) = 430[M + +1] Example 106 : Synthesis of N-[2-(3,4-dihydroxyphenyl)-3- hydroxy-4-oxo-4H-chromen-6-yl]-N'-(4-nitrophenyl)urea (compound 61) 24mg (Yield 98%) of the title compound was obtained according to the same procedure as Example 99 except that 25mg (54 pmol) of the compound obtained in Example 56 was used instead of the compound obtained in Example 49. Η NMR(DMSO-dό, ppm); δ 9.57(1H, s), 9.28(1H, s), 8.32(1H, s), 8.22(2H, d), 7.74-7.60(6H, m), 6.90(1H, d). FAB MS (m/e) = 450[M + +1] Example 107 : Synthesis of N-(4-aminophenyl)-N'-[2-(3,4- dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]urea (compound 62) 16mg (35.6 pmol) of the compound obtained in Example 106 was dissolved in 2m£ of methanol, catalytic amount of 10% Pd/C was added thereto, and the mixture was reacted under latin of hydrogen gas for 3 homs. The resulting product was filtered through celite pad, and washed with methanol. Then the filtrate was concenfrated under reduced pressure to give 3.5mg of the title compound in a yield of 23%. 1H NMR(DMSO-d 6 , ppm) ; δ 9.55(1H, s), 9.28(1H, s), 9.20(1H, s), 8.93(1H, s), 8.43(1H, s), 8.25(1H, s), 7.73-7.59(4H, m), 7.21(2H, d), 6.90(1H, d), 6.69(2H, d). FAB MS (m/e) = 420[M + +1] Experimental Example 1 Analysis of inhibitory activity against CDK2/cyclin A and CDK4/cyclin DI enzyme The inhibitory activity against CDK2 is measured by referring to Kitagawa,M. et al., Oncogene 9:2549, 1994 and the inhibitory activity against CDK4 is measured by referring to Carlson,B.A. et al., Cancer Research 56:2473,1996. As for CDK2, either the extract from the insect cell infected both with baculovirus which expresses CDK2 gene and baculovirus which expresses cyclin A gene or the active enzyme which had been purified therefrom was used. CDK4 enzyme was also obtained from the insect cell infected both with baculovirus expressing CDK4 gene and baculovirus expressing cyclin DI gene. As the substrate for CDK2, either histon HI or Rb protein was used. Rb protein was also used as the substrate for CDK4. Specifically the activities of enzymes CDK2/cyclin A and CDK4/cyclin DI were determined according to the following procedme. lOOng of enzyme was reacted in a total lOO β of 20mM Tris (pH 8.0), lOOmM NaCl, lOmM MgCb buffer solution containing 20 g of GST-RB protein, 100 M of ATP and 5 Ci of P 32 - / -ATP at 30°C for 30 minutes. Then, the enzyme reaction was stopped by adding EDTA to a concenfration of 20mM. Subsequently, 30 μi of 50% glutathione bead (purchased from Pharmacia) was added to attach GST-RB to the bead, which was washed three times with 20mM Tris (pH 8.0), lOOmM NaCl, lOmM EDTA solution, and then scintillation counting was carried out. To analyze the inhibitory activity of the compound, the inhibitor having a proper concenfration was added to the enzyme reaction solution, and then the enzyme activity was measured according to the above method. The inhibitory activity of the compound of formula (1) according to the present invention against CDK2 and CDK4 is represented as IC50 value. The test results are shown in the following Table 1. The compounds which are not included in Examples(compound 63, 64, 65 and 66) were synthesized and purified according to the same procedme as examples, and then IC50 thereof was measured. [Table 1] As can be seen from the results described in the above Table 1, since the novel flavone derivative of formula (1) according to the present invention has an excellent inhibitory activity against CDK2 and CDK4, it can be used advantageously as an anti-cancer agent. In addition, it can be useful as an agent for treating nemodegenerative disease because it has an inhibitory activity against CDK5 which is a homology with CDK2 and is included in the same family(Ref. : John Leu et al., "Neuronal CDC2-like kinase", TIBS, January 1995, pp33~37). Experimental Example 2 Acute toxicity experiment The acute oral toxcities of the compounds 14, 17, 28, 39, 51 and 57 each of which is obtained in Examples 14, 17, 73, 84, 96 and 102, respectively are investigated in the following. Solutions containing a compound in several different concenfrations from each other were prepared, and they were administered orally to ICR male mouse with a dose of lOml/kg. After adminisfration, lethality and symptoms for 7 days were observed, and LD50 (mg/kg) was calculated according to Litchfield- Wilcoxon' method. The results are represented in the following Table 2. [Table 2]

Claims: WHAT IS CLAIMED IS: 1. A compound represented by the following formula (1) in which Ri, R3 and R each independently represent hydrogen, halogen, hydroxy, alkyl, lower alkoxy, amino or nifro, R 2 represents hydrogen, halogen, hydroxy, lower alkyl, lower B l _ alkoxy, amino, nifro or wherein A represents amino which may be optionally substituted with alkyl, cycloalkyl, aralkyl, acyl, or aryl which is optionally substituted with one or two substituents selected from the group consisting of halogen, cyano, nitro and amino ; or 1,2,3,4-tefrahydroisoquinoline which may be optionally substituted with halogenoalkylcarbonyl ; or alkyl, aryl, aralkyl or heteroaryl each of which may be optionally substituted with one or two substituents selected from the group consisting of alkyl, halogenoalkyl, halogen, dialkylamino, phenyl, nifro, amino, isooxazole, pyridine, carboxy, morpholine, methylpiperazine and cyano, Y represents S0 2 or CO, B represents hydrogen or alkyl, R5 represents hydrogen or hydroxy, and Rό and R7 are substituted at o-, m- or /^-position from each other and each independently represents hydrogen, hydroxy, halogen or lower alkoxy or together represent lower alkylenedioxy, pharmaceutically acceptable salt, hydrate, solvate and isomer thereof. 2. The compound of claim 1, wherein Ri, R 2 , R3 and R4 each independently represent hydrogen, halogen, hydroxy, lower alkoxy or nifro(provided that two or more of these four substituents are hydrogen), R5 represents hydrogen or hydroxy, and Rό and R 7 are substituted at o-, m- or ^-position from each other and each independently represents hydrogen, hydroxy, halogen or lower alkoxy or together represent lower alkylenedioxy. 3. The compound of claim 2, wherein Ri, R 2 , R3 and Rt each independently represent hydrogen, chloro, hydroxy, methoxy or nifro(provided that two or more of these four substituents are hydrogen), R represents hydrogen or hydroxy, and Rό and R 7 are substituted at o-, m- or /^-position from each other and each independently represents hydrogen, hydroxy, chloro or methoxy or together represent methylenedioxy. 4. The compound of claim 1, wherein Ri represents hydrogen, hydroxy, lower alkoxy or amino, R 2 and R3 each independently represent hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or amino, R4 represents hydrogen, halogen, hydroxy or lower alkoxy, R5 represents hydroxy, and Rό and R 7 represent 3-hydroxy and 4-hydroxy respectively. 5. The compound of claim 4, wherein Ri represents hydrogen, hydroxy or lower alkoxy, R 2 represents hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or amino, R3 represents hydrogen, hydroxy, lower alkyl, lower alkoxy or amino, and R4 represents hydrogen, halogen or hydroxy. 6. The compound of claim 5, wherein Ri represents hydrogen, hydroxy or methoxy, R 2 represents hydrogen, bromine, hydroxy, methyl or amino, R3 represents hydrogen, hydroxy, methyl, methoxy or amino, and Rt represents hydrogen, halogen or hydroxy. 7. The compound of claim 1, wherein Ri, R3 and R4 each independently represent hydrogen, halogen, hydroxy, alkyl or amino(provided that two or more of these three substituents are hydrogen), B l _ R 2 represents , wherein A represents amino which may be optionally substituted with alkyl, cycloalkyl, aralkyl, acyl, or aryl which is optionally substituted with one or two substituents selected from the group consisting of halogen, cyano, nifro and amino ; or 1,2,3,4-tefrahydroisoquinoline which may be optionally substituted with halogenoalkylcarbonyl ; or alkyl, aryl, aralkyl or heteroaryl each of which may be optionally substituted with one or two substituents selected from the group consisting of alkyl, halogenoalkyl, halogen, dialkylamino, phenyl, nifro, amino, isooxazole, pyridine, carboxy, morpholine, methylpiperazine and cyano, Y represents S0 2 or CO, B represents hydrogen or alkyl, R5 represents hydroxy, and Rό and R 7 represent 3-hydroxy and 4-hydroxy respecitvely. 8. The compound of claim 7, wherein Ri, R3 and R4 each represent hydrogen, A represents amino which may be optionally substituted with cycloalkyl ; or 1,2,3,4-tefrahydroisoquinoline which may be optionally substituted with halogenoalkylcarbonyl ; or alkyl, aryl, aralkyl or heteroaryl each of which may be optionally substituted with one or two substituents selected from the group consisting of alkyl, halogenoalkyl, halogen, dialkylamino, phenyl, nifro, amino, isooxazole, pyridine, carboxy, morpholine and methylpiperazine, Y represents S0 2 , and B represents hydrogen. 9. The compound of claim 8, wherein A represents 1,2,3,4-tefrahydroisoquinoline which may be optionally substituted with halogenoalkylcarbonyl ; or aryl or heteroaryl each of which may be optionally substituted with one or two substituents selected from the group consisting of alkyl, halogenoalkyl, halogen, dialkylamino, phenyl, nifro, amino, isooxazole, pyridine, carboxy, morpholine and m ethylpiperazine . 10. The compound of claim 7, wherein Ri, R3 and Rt each represent hydrogen, A represents amino which may be optionally substituted with cycloalkyl, aralkyl, acyl, or aryl which is optionally substituted with one or two substituents selected from the group consisting of halogen, cyano, nifro and amino ; or alkyl or aryl each of which may be optionally substituted with halogen, Y represents CO, and B represents hydrogen. 11. The compound of claim 10, wherein A represents amino which is substituted with aryl which is substituted with one or two substituents selected from the group consisting of halogen, cyano, nifro and amino. 12. The compound of claim 1 which is selected from a group consisting of 2-(4-chloro-phenyl)-7-methoxy-chromen-4-one, 7-methoxy-2-phenyl-chromen-4-one, 7-hydroxy-2-phenyl-chromen-4-one, 2-(benzo[l,3]dioxol-5-yl)-3-hydroxy-5-methoxy-chromen-4-one, 2-(benzo[l,3]dioxol-5-yl)-3-hydroxy-6-methoxy-chromen-4-one, 2-(benzo[l,3]dioxol-5-yl)-3-hydroxy-7-methoxy-chromen-4-one, 3-hydroxy-7-methoxy-2-(4-methoxy-phenyl)-chromen-4-one, 2-(4-chloro-phenyl)-3-hydroxy-7-methoxy-chromen-4-one, 6-chloro-3-hydroxy-2-(4-methoxy-phenyl)-8-nitiO-chromen-4-one, 6, 8-dichloro-3 -hydroxy-2-(4-methoxy-phenyl)-chromen-4-one, 3-hydroxy-2-(4-methoxy-phenyl)-chromen-4-one, 6-chloro-2-(3 ,4-dihydroxyphenyl)-3 -hydroxy-4H-chromen-4-one, 6-bromo-2-(3 ,4-dihydroxyphenyl)-3 -hydroxy-4H-chromen-4-one, 2-(3,4-dihydroxyphenyl)-3,6-dihydroxy-4H-chromen-4-one, 6-amino-2-(3,4-dihydroxyphenyl)-3-hydiOxy-4H-chromen-4-one, 2-(3 ,4-dihy droxyphenyl)-3 -hydroxy-6-methoxy-4H-chromen-4-one, 6-fluoro-2-(3 ,4-dihydroxyphenyl)-3 -hydroxy-4H-chromen-4-one, 6-methyl-2-(3,4-dihydroxyphenyl)-3-hydroxy-4H-chromen-4-one, 6, 8-dichloro-2-(3 ,4-dihy droxyphenyl)-3 -hy droxy-4H-chromen-4-one, 6,8-dibromo-2-(3,4-dihydroxyphenyl)-3-hydroxy-4H-chromen-4-one, 6, 8-difluoro-2-(3 ,4-dihy droxyphenyl)-3 -hydroxy-4H-chromen-4-one, 6-chloro-2-(3,4-dihydroxyphenyl)-3-hydroxy-7-methyl-4H-chromen-4- one, 2-(3 ,4-dihy droxyphenyl)-3 -hydroxy-7-methoxy-4H-chromen-4-one, 2-(3 ,4-dihy droxyphenyl)-3 , 8-dihydroxy-7-methoxy-4H-chromen-4-one, 2-(3 ,4-dihy droxyphenyl)-3 , 8-dihydroxy-4H-chromen-4-one, 2-(3,4-dihydroxyphenyl)-6,7-dimethyl-3-hydroxy-4H-chromen-4-one, 2-(3,4-dihydroxyphenyl)-3-hydroxy-5-methoxy-4H-chromen-4-one, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-4- methylbenzenesulfonamide, 4-bromo-N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6- yl]benzenesulfonamide, 3-bromo-N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6- yl]benzenesulfonamide, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-2- naphthalenesulfonamide, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-5-(di- methylamino)- 1 -naphthalenesulfonamide, N-[2-(3 ,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-2-( 1 - naphthyl)- 1 -ethanesulfonamide, 4,5-dibromo-N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-2-thiophenesulfonamide, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-[l, r- biphenyl]-4-sulfonamide, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-5-(iso -oxazolyl)-2-thiophenesulfonamide, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-5-(2- pyridinyl)-2-thiophenesulfonamide, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-3,4-di -fluorobenzenesulfonamide, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-4-(fri- fluoromethyl)benzenesulfonamide, 4-chloro-N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6- yl]-3-mtrobenzenesulfonamide, 3-chloro-N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6- yl]- 1-propanesulfonamide, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-2,4-di -fluorobenzenesulfonamide, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-4- fluorobenzenesulfonamide, N-[2-(3 ,4-dihydroxyphenyl)-3 -hydroxy-4-oxo-4H-chromen-6-yl]-2-(2, 2,2-frifluoroacetyl)-l,2,3,4-tefrahydro-7-isoquinolinesulfonamide, 4-({[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]- amino}sulfonyl)benzoic acid, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-l,2,3, 4-tefrahydro-7-isoquinolinesulfonamide, N-cyclohexyl-N'-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]-sulfide, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-4-(4- morpholinyl)-3-nifrobenzenesulfonamide, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-4-(4- methyl- 1 -piperazinyl)-3 -nifrobenzenesulfonamide, 3-amino-N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6- yl]-4-(4-methyl- 1 -piperazinyl)benzenesulfonamide, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]- acetamide, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]- benzamide, 4-chloro-N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6- yl]benzamide, N-benzyl-N'-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6 -yl]mea, N-(4-bromophenyl)-N'-[2-(3 ,4-dihydroxyphenyl)-3 -hydroxy-4-oxo-4H- chromen-6-yl]urea, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-N'- phenyl ea, N-benzoyl-N'-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen- 6-yl] ea, N-(3-bromophenyl)-N'-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]urea, N-(2,4-dichlorophenyl)-N'-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo- 4H-chromen-6-yl]- ea, N-(3-cyanophenyl)-N'-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]urea, N-[2-(3,4-dihydroxyphenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-N'-(4- nifrophenyl)urea, N-(4-aminophenyl)-N'-[2-(3 ,4-dihy droxyphenyl)-3-hydroxy-4-oxo-4H- chromen-6-yl]urea, 2-(3,4-dihydroxyphenyl)-3-hydroxy-4H-chromen-4-one, 2-(3 ,4-dihy droxyphenyl)-3 , 7-dihydroxy-4H-chromen-4-one, 2-(3,4-d_hydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one, and 2-(3,4-dihydroxyphenyl)-3,7,8-trihydroxy-4H-chromen-4-one. 13. A process for preparing the compound of formula (1) as defined in claim 1, characterized in that a) a compound of formula (5) : wherein R_, R 2 , R 3 , RΛ, RO and R 7 are defined as claim 1, is prepared by cyclizing a compound of formula (4) : wherein Ri, R 2 , R3, R4, Rό and R7 are defined as claim 1, in the presence of triflomoacetic acid, then thus obtained compound of formula (5) is oxidized in the presence of a oxidizing agent in a solvent to produce a compound of formula (la) : wherein Ri, R 2 , R3, R», Rό and R 7 are defined as claim 1; or b) a compound of formula (6) : wherein Ri, R2, R3, R4, Rό and R 7 are defined as claim 1, is cyclized in the presence of sodium acetate in a solvent to produce the compound of formula (la) ; or c) the compound of formula (4) is cyclized in the presence of a base and hydrogen peroxide in a solvent to produce a compound of formula (lb) : wherein Ri, R 2 , R3, R4, Rό and R7 are defined as claim 1; or d) one to six lower alkoxy groups or alkylenedioxy group in the compound of formula (1) are deprotected in the presence of boron tribromide(BBr3) and converted into hydroxy or dihidroxy group to produce a compound of formula (1) wherein one to six of the substituents R_, R2, R3, R4, Rό and R 7 are hydroxy ; or e) a compound of formula (4a) : wherein Rj, R 2 , R 3 and R4 are defined as claim 1, is prepared by reacting 2-hydroxyacetophenone derivative of formula (7) : wherein Ri, R 2 , R3 and Ri are defined as claim 1, with piperonal of formula (8a) : in the presence of a base in a solvent, then thus obtained compound of formula (4a) is cyclized in the presence of hydroxy peroxide to produce a compound of formula (lcc) : wherein Ri, R 2 , R3 and R4 are defined as claim 1 ; or f) the produced compound of formula (lcc) is reacted with boron fribromide (BB13) to produce a compound of formula (ldd) : wherein Ri, R 2 , R3 and R4 are defined as claim 1 ; or g) a compound of formula (4b) wherein Ri, R3, R4 and B are defined as claim 1, is prepared by reacting 2-hydroxyacetophenone derivative of formula (7a) : wherein Ri, R3, R4 and B are defined as claim 1, the piperonal of formula (8a), and sodium hydroxide in the aqueous ethanol solution solvent, then thus obtained compound of formula (4b) is reacted with aqueous sodium hydroxide and hydrogen peroxide in methanol solvent to produce a compound of formula (le) : wherein Ri, R 3 , Rt and B are defined as claim 1 ; or h) a compound of formula (9a) : wherein Ri, R3, Rt and B are defined as claim 1, is prepared by hydrolyzing the produced compound of formula (le) with aqueous sulfuric acid solution in alcoholic solvent, then thus obtained compound of formula (9a) is reacted with a compound of formula (10) A-Y-X (10) wherein A and Y are defined as claim 1 and X is a leaving group or with a compound of formula (11) : A * -NOO (11) wherein A 1 represents aralkyl, acyl or aryl which is optionally substituted with one or two substituents selected from the group consisting of halogen, cyano and nifro, to produce a compound of formula (lhh) : wherein Ri, R3, Rt, A, Y and B are defined as claim 1; or i) the produced compound of formula (lhh) is reacted with boron tribromide (BBr 3 ) in methylenechloride solvent to produce a compound of formula (li) : wherein Ri, R 3 , Rt, A, Y and B are defined as claim 1. 14. A composition of anti-cancer agent comprising the compound of formula (1), pharmaceutically acceptable salt, hydrate, solvate or isomer thereof as defined in claim 1 as an active ingredient with pharmaceutically acceptable carriers. 15. A composition of agent for treating neurodegenerative disease comprising the compound of formula (1), pharmaceutically acceptable salt, hydrate, solvate or isomer thereof as defined in claim 1 as an active ingredient with pharmaceutically acceptable carriers.

Inventors: HONG CHANG-YONG, KIM DONG-MYUNG, KIM EUNICE EUN-KYEONG, KIM JONG-HYUN, KIM SANG-WOONG, KIM YOUNG-KWAN, LEE JIN-HO, PARK TAE-SIK, SON HO-SUN, HONG, CHANG-YONG, KIM, DONG-MYUNG, KIM, EUNICE, EUN-KYEONG, KIM, JONG-HYUN, KIM, SANG-WOONG, KIM, YOUNG-KWAN, LEE, JIN-HO, PARK, TAE-SIK, SON, HO-SUN
Applicants: HONG CHANG YONG, KIM DONG MYUNG, KIM EUNICE EUN KYEONG, KIM JONG HYUN, KIM SANG WOONG, KIM YOUNG KWAN, LEE JIN HO, LG CHEMICAL LTD, PARK TAE SIK, SON HO SUN, HONG, CHANG-YONG, KIM, DONG-MYUNG, KIM, EUNICE, EUN-KYEONG, KIM, JONG-HYUN, KIM, SANG-WOONG, KIM, YOUNG-KWAN, LEE, JIN-HO, LG CHEMICAL LTD., PARK, TAE-SIK, SON, HO-SUN
Application year: 1999
Main classification: C07D311
IPC codes: A61K31, A61P25, A61P35, A61P43, C07D311, C07D401, C07D405, C07D407, C07D409, C07D413