MULTIMOLECULAR DEVICES, DRUG DELIVERY SYSTEMS AND SINGLE-MOLECULE SELECTION

Abstract: Single-molecule selection methods are provided for detecting and identifying useful synthetic nucleotides, e.g., aptamers, ribozymes, catalytic DNA molecules, nucleotide catalysts, nucleotide ligands and nucleotide receptors. Methods for selecting shape-specific probes and specifically attractive surfaces are also provided. Paired nucleotide-nonnucleotide mapping libraries for transposing selected populations of selected nonoligonucleotide molecules into selected populations of replicatable nucleotide sequences are also provided. Aptameric and nonaptameric multimolecular devices, imprints and delivery systems are also provided, including molecular adsorbents, adherents, adhesives, transducers, switches, sensors and drug delivery systems.

Description: MULTIMOLECULAR DEVICES, DRUG DELIVERY SYSTEMS AND SINGLE-MOLECULE SELECTION Field of the Invention This invention relates to multimolecular deuces and drug deli er} s\ stems which optional.} compnse syntheuc nucleotide molecules and to single-molecule selection methods for identiiung useful synthetic nucleotide molecules, e.g., aptamers, πbozymes, catalytic DNA, nucleotide catalysts, nucleotide ligands and nucleoude receptors. Applications include pharmaceuticals, medical devices, diagnostics, cosmetics, dentistrv, nutraceuucals, agπceuucals, environmental remediation, industrial pohmers, packaging, microelectronics, nanofabncauon and molecular manufacturing. Molecular adhesives, adherents, adsorbents and multimolecular switches, sensors, transducers and deliven systems are produced b\ template-directed assembl Background of the Invention The development of effectiv e and reliable multimolecular deuces such as receptor- activated drug deliver} systems, molecular-scale sensors, switches, transducers and actuators requires control over the relative position of molecules within mulumolecular structures Molecules covalent attachment (i.e., chemical bonds) or noncovalent means, including self-assembh , specific banding, hybndizauon of complementan nucleic acid sequences, ionic bonding, hydrophobic interactions, intercalation, chelation and coordination of metals. However, precise, reproducible and scalable methods for production of useful syntheuc mulumolecular devices with positional control at the molecular scale have heretofore been lacking. A general method is descnbed in Cubicciotti, U.S. 5,656,739 which provides for controlled placement of two or more selected molecules in appropπate spatial proximity to produce cooperative molecular assemblies. This method yields self-assembling multimolecular heteropolymeπc complexes through use of synthetic heteropolymers or multivalent heteropolymenc hybπd structures comprising nucleotides having defined sequence segments with affinities for identified molecules. Cubicciotti, U.S. 5,656,739 describes the advantages of synthetic oligonucleotides as assembly templates. Template- ordered molecules cooperate when brought into close spatial proximity , much like ordered biological molecules in living systems. Nucleic acids are particularly useful assembly templates not just because they can be selected to specificalh bind nonoligonucleotide target molecules with high affinity (e.g., Tuerk and Gold (1990) Science 249:505-510), nor because the} can hybπdize by complementary base pairing. More important, only nucleic acids are capable both of hybridizing other nucleic acids and specificalh binding nonoligonucleotide molecules. Both iorms of recognition can be programmably synthesized into in a single molecule or hybridized into a single discrete structure. A single nucleic acid molecule with two different binding specificities (i.e., a svnthetic heteropohmer) can be synthesized at the push of a button and two or more s}nthetιc heteropolymers can be h}bndιzabh linked to one another. Nucleotide-directed molecular assembh prov ides a general solution to the problem oi molecular positioning b\ exploiting several ke} attπbutes oi synthetic oligonucleotides First, oligonucleotides can be designed or selected, e.g., b} combinatoπal methods, to specificalh bind molecules of nearl} any size and shape ith high affinit}, not simph other nucleic acids as once thought. Second, the informational properties of nucleotides enable reproducible svnthesis of single oligonucleotides having two or more specific binding sites in defined spatial proximity within a single molecule. Third, the base pairing properties of nucleotides enable the splicing of any two useful binding sequences into a single discrete structure (I e., a bifunctional hybπd structure) by programmable self-a sembly (i.e., hybridization) Fourth, oligonucleotides compnsmg modified nucleotides can be used to attach selected molecules (e.g., ligands, receptors, structural or eifector molecules) at the 3' or 5' ends or at defined positions along the nucleotide sequence. Multivalent assembh structures can therefore be designed to speciiically recognize different effector molecules and position them to perform cooperative functions such as energ} transfer, signal transduction, multistep enzvmatic processing, molecular sensing, molecular switching and targeted or tπggered molecular delivery, release and/or activation, e.g., as particularly useful in drug deliver}. Designer oligonucleotides can be cost-effectiveh produced at large scale using automated synthesizers, and they can be convenienth attached to surfaces and nanostructures to permit self-assembly of immobilized dev ices and on-chip molecular arrays. Single-stranded and double-stranded nucleic acids capable of specifically binding nonoligonucleotide molecules may be identified and produced using in vivo or in vitro methods known in the art (for reviews, cf. Famulok and Szostak ( 1993) In: Nucleic Acids and Molecular Biology, pp. 271-284 Spπnger- Verlag, Berlin; Fitzwater et al. (1996) Methods in Enzymology 267:275-301; Gold et al. (1995) Annu. Rev. Biochem. 64:763- 797. For example, recombinant DNA methods have been used to produce modified host cells compnsing stochastic synthetic polynucleotides for screening and selection of DNA or RNA sequences showing a desired property (Bal vet et al., GB 2 183 661 A; Kauffman et al., U.S. 5,763,192). A vanety of in vitro selection methods has also been descnbed for identifying nucleic acids that bind nonoligonucleotide molecules (e.g., Gold et al., U.S. 5,270,163), including single-stranded RNA (e.g., Ellington and Szostak (1990) Nature 546:818-822), single-stranded DNA (e.g., Bock et al. (1992) Nature 255:564-566, Wang et al. (1993) Biochemistry 32:1899-1904), and double-stranded DNA (e.g., Bie nska et al. (1990) Science 250:997-1000) aptamers. By way of example, single-stranded and double- stranded RNA and DNA aptamers can be selected in vitro b\ methods including, but not limited to, those of Ellington et al. (Ellington and Szostak, Nature 346:818-822) and Biehnska (Biehnska et al. (1990) Science 250:997-1000) which rely on ennchment cycles compnsing alternating amplification and selection steps. Follow ing is a bnef summary of these methods, for illustrative purposes only. For DNA aptamers, a library of o gonucleotide sequences (sequence library) is synthesized compnsing a randomized nucleotide region flanked by two deiined polymerase chain reacuon (PCR) pnmer binding sites. The sequence libraπ is amplified to yield double-stranded PCR products. To select for double-stranded DNA aptamers, the resultant population of double-stranded PCR products is then incubated (sans pnmer biotinylation and strand separation) with an identified target molecule (e.g., a target protein). For preparation of single-stranded aptamers, the downstream PCR pnmer is biotinylated at the 5' end and PCR products are applied to an avidin-agarose column. Smgle-stranded DNA oligonucleotides are recovered by elution with a weakly basic buffer. Resultant DNA strands are incubated w ith a selected target molecule (e.g., a target protein) either in solution or bound to a filter, chromatography matnx or other solid support. Nonbinding sequences are separated from binding sequences, e.g., b} selective elution, filtration, electrophoresis or alternative means oi partitioning bound from free fractions. T}pιcalh, preselection and/or counterselection steps are included in the selection protocol to select against (i.e., remove or discard) nucleic acids that bind to nontarget substances (e.g., to a filter, gel, plastic surface or other partitioning matnx) and/or irrelevant epitopes (e.g., the membrane portion of a membrane-associated receptor). Target- bound DNA sequences are then dissociated from the target and subjected to another round of PCR amplification, binding and partitioning. After several rounds oi ennchment and or affinity maturation, the final amplification step may be performed with modified pπmers allowing subcloning into a plasmid restnction site and sequencing of target-binding positive clones. For RNA aptamers, the ohgonucleotide sequence library is amplified to yield double-stranded PCR products containing a T7 bactenophage polymerase promoter site. RNA molecules are then produced by in vitro transcnption using T7 RNA polymerase. The resultant single-stranded RNA pool is then incubated with the selected target molecule, optionally immobilized. Target-bound RNA is separated from unbound RNA, e.g., by elution, filtration or alternaϋve partitioning procedures, and reverse transcnbed to DNA. The resultant population of DNA molecules is then amplified to produce a second round of double-stranded DNA products compnsing the T7 RNA polymerase promoter. After repeated cycles of amplification and selection, modified PCR pnmers are used to allow subcloning into a plasmid and sequencing of selected clones. Pπor art methods for identifying nonnaturalh occurnng nucleic acid molecules capable of specifically binding nonoligonucleotide targets (i.e., for selecting aptamers or nucleic acid ligands) rely particularly on the steps of partitioning and amplification. For example, Gold et al., U.S. 5,270,163 descnbe a method referred to as SELEX (Systematic Evolution of Ligands by Exponential Ennchment) for the identification of nucleic acid ligands as follows. A candidate mixture of single-stranded nucleic acids hav ing regions of randomized sequence is contacted with a target compound and those nucleic acids having an increased affinity to the target are partitioned from the remainder of the candidate mixture. The partitioned nucleic acids are amplified to yield a ligand ennched mixture. AddiUonal SELEX-based methods are disclosed, e.g., in Gold et al., U.S. 5,567,588; Gold et al, U.S. 5,705,337; Gold et al., U.S. 5,707,796; Jensen et al., U.S. 5,712,375; Eaton et al., U.S. 5,723,289; and Eaton et al., U.S. 5,723,592). Gold et al., U.S., 5,475,096 descnbe nucleic acid ligands having a specific binding affinity tor three dimensional molecular targets. Molecular targets include proteins selected from the group consisting of nucleic acid polymerase, bactenophage coat protein, seπne protease, mammalian receptor, mammahan hormone, mammalian growth factor, nbosomal protein, and viral rev protein. SELEX-based methods for in vitro selection of nucleic acid ligands against complex targets (e.g., red cell ghosts) have also been descnbed (Vant-Hull et al. (1998) J. Mol. Biol. 278:579-597; Morns et al. (1998) Proc. Natl. Acad. Sci. USA 95:2902-2907). Bock et al. ( 1992; Nature 255:564-566) descnbe a method for identifying oligomer sequences that specifically bind target biomolecules involving complexation of the support- bound target molecule with a mixture of oligonucleotides containing random sequences and sequences that can sen e as pnmers for PCR . The target-ohgonucleotide complexes are then separated from the support and the uncomplexed oligonucleotides, and the complexed oligonucleotides are recovered and subsequently amplified using PCR The recovered oligonucleotides ma} be sequenced and subjected to successiv e rounds of selection using complexation, separation, amplification and recover} . Szostak et al., U.S. 5,631,146 descnbe single-stranded DNA molecules which bind adenosine and methods for their production and isolation. Also disclosed are methods for producing and isolating related catalytic DNA molecules. Gnffin et al., U.S. 5,756,291 disclose a method for identifying oligomer sequences, optionalh compnsing modified base, which specifically bind target molecules such as serum proteins, kinms, eicosanoids and extracellular proteins. Unnatural bases and modified nucleotides compnsing synthetic oligonucleotides are useful as diagnostic reagents, molecular biology tools and probes of nucleic acid structure and function (e.g., Goodchild (1990) Bioconjugate Chemistry 7: 165-187; Beaucage et al. (1993) Tetrahedron 49: 1925-1963). Pnor art modified nucleotides include natural bases linked by spacers arms to molecular reporters (e.g., spin labels, fluorophores, quenchers, DNP, digoxigenin and biotin) and analogs designed to enhance duplex stabiht} and chemical stability. Novel bases (i.e., analogs) include unnatural nucleotides designed to increase coding diversity (e.g., Piccinlh et al. (1990) Nature 343:33-37. Nucleic acids are useful matenals for programmable self-assembly, because the bases and backbone can be extensiveh modified without compromising molecular recognition properties, stability or hybndization rates and without destroying the relativeh ngid structure of short duplex oligonucleotides. Several nucleotide positions can be modified by addition of tethered substituents without significantly affecting duplex structure (e.g., the N2 and N7 positions of guanine, the N6 and N7 positions oi adenine, C5 position of cytosine, thymidine and uracil, and the N4 position oi cytosine). The pnor art does not, however, descnbe nucleotide analogs and modified nucleotides designed to introduce heretofore unknown ligands and receptors to enable functional coupling between pairs ot specific binding pairs. Also, nucleotides can be modified by covalent attachment of ligands (e.g., DNP. digoxigenin. biotin) and receptors (e.g., antibodies), but the art is silent with respect to use ot nucleotides as positioning devices for attachment of multiple specific binding pairs in suitable juxtaposition to enable functional coupling between, e.g., two specifically bound effector molecules. Burke et al., U.S. 5,637,459 disclose methods for producing chimenc nucleic acid molecules v ith two or more functions. A chimenc library is generated in which individual chimenc molecules combine the functions or charactenstics oi two or more parent libraries, each parent library having been selected through the SELEX procedure for a specific function or feature The chimenc molecules are useful, e.g., in providing improved affinities for a target molecule, enhancing the assembh oi multi -component molecules, and promoting reactions bet een two molecules. Shih et al., U.S. 5,589,332 descnbe a s}stem for using a πbozyme as a diagnostic tool for detecting the presence of a nucleic acid, protein or other molecule. The formation of an activ e πbozyme and cleav age of an assayable marker is dependent on the presence or absence of the specific target molecule. The essential component is a πbozyme specificalh but rev ersibh binding a selected target in combination with a labeled co-target, preferabh immobilized on a support structure. Burke et al., U.S. 5,663,064 disclose πbozymes having a ligand binding site formed as a double-stranded RNA and a smgle-stranded loop, the πbozyme having enzymatic activity to cleav e and or gate itself or a separate RNA molecule. Meade et al., U.S. 5,705,348 and U.S. 5,591,578 descnbe nucleic acid mediated electron transfer relying on the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieues are covalenth bound to the nbose-phosphate backbone of the nucleic acid at predetermined positions. The resulting complexes represent a senes of new deπvativ es that are biomolecular templates capable of transf erπng electrons o er very large distances at extremeh fast rates. Tyagi et al. (1996; Nature (Biotechnology.) 74:303-308) describe novel nucleic acid probes that recognize and report the presence of specific nucleic acids in homogeneous solutions. These probes undergo a spontaneous fluorogemc coniormational change when they hybndize to their targets. Lizardi et al., U.S. 5,118,801 descnbe a probe for the detection oi a nucleic acid target sequence containing a molecular switch compnsing three essential elements: a probe sequence of 20-60 nucleotides surrounded by switch sequences ot 10-40 nucleotides which are complementan to each other, wherein the state oi the switch is useful for selectiveh generating a detectable signal if the probe is hybπdized to a target Molecular impnnting techniques have been descnbed which allow tor the preparation ot polymenc receptors capable oi binding small molecules with affinities and selectiv lties of the same order as those obsened in the binding ot antigens by antibodies (for review , see Sellergren ( 1997) Trends Anal. Chem. 76:310-320) Shea et al. (1993; J. Am. Chem. Soc. 775:3368-3369) descnbe impnnt polymers with strong binding sites to nucleotide bases. The technique employed is refened to as template polymeπza on, whereb} functional monomers are preorgan zed about a template or impnnting monomer pπor to their copolymeπzation with crosshnking polymers Spivak et al. (1998; Macromolecules 37:2160-2165) descnbe specific binding of both RNA and DNA nucleotide bases b} impnnt polymers. Single-molecule detection has been demonstrated with a vaπety of signal- generating species. Detection of individual molecules of low molecular weight fluorophores (e.g., rhodamine) and high molecular weight phycobihproteins (e.g., phycoerythπn) has been reported (e.g., Shera et al. (1990) Chem. Phxs. Lett. 774-553-557; Soper et al. ( 1991) Anal. Chem. 63:432-437; Peck et l. (1989) Proc. Natl. Acad. Sci. USA 86:4087-4091). Ulmer, U.S. 5,674,743 discloses a method for single-molecule DNA sequencing. The method includes the steps of a) using a processing exonuclease to cleave from a single DNA strand the next available single nucleotide on the strand, b) transporting the single nucleotide away from the DNA strand, c) incorporating the single nucleotide in a fluorescence-enhancing matnx, d) irradiating the single nucleotide to cause it to fluoresce, e) detecting the fluorescence, f) identifying the single nucleotide b} its fluorescence, and g) repeating steps a) to 0 indefinitely (e.g., until the DNA strand is fully cleaved or until a desired length of the DNA is sequenced). Optical trapping methods are known in the art (e.g., Ashkin et al. (1987) Nature 330:769-771; Frej et al. (1993) J. Chem. Phys. 98:7552-7564; Sasaki et al. (1991) Opt. Lett. 76:1463-1465; Sasaki et al. (1992) Appl. Phys. Lett. 60:807-809), as are SPM-based detection and extraction methods (e.g., Henderson (1992) Nucleic Acids Research 20:445- 447, Hansma et al. ( 1992) Science 256: 1180-1184; Weisenhorn et al. (1990) Scanning Microscopy 4:511-516). DNA fragment sizing and sorting by laser-induced fluorescence is disclosed by Hammond et al., U.S. 5,558,998. A method is provided for sizing DNA fragments using high speed detection systems such as flow cytometry to determine unique characteπsUcs of DNA pieces from a sample. Nanometer-scale measurements on individual DNA and protein molecules have been demonstrated, e.g., using AFM and STM, enabling resolution of interactions between individual DNA and protein molecules (e.g., Allen et al. ( 1993) Biochemistry 32:9390). Linker DNA of chromatin fibers was shown to compnse 3780 base pairs with 18 tandem repeats of 208-base pair positioning sequences. Measured changes in fiber length were consistent with 146-base pair DNA wrapped 1.75 times around a nucleosome core. Protein- induced DNA bending in response to binding of RNA polymerase and Cro protein molecules has also been resolved (Rees et al. ( 1993) Science 260: 1646). Direct imaging of DNA-protein complexes enabled discπmination between specific and nonspecific binding. STM has been used to image synthetic ohgonucleotide duplexes alone or with intercalativeh -bound metal complexes with submolecular resolution (Kim et al., (1991) Scanning Microscopy 5:311-316) and to study the interactions of DNA with fluorescent dyes (Zareie et al. ( 1998) Int. J. Biol. Macromol. 23:7-10). STM images of nucleotide bases have been obtained with atomic resolution (Allen et al. (1991) Scanning Microscopy 5:625- 630). STM and AFM have also been used to image synthetic DNAs and DNA protamine complexes (Allen et al. (1993) Scanning Microscopy 7:563-574; Allen et al. ( 1997) Nucleic Acids Res. 25:2221-2226; Jing et al. (1993) Proc. Natl. Acad. Sci. USA 90:8934-8938). In efforts to sequence DNA by AFM imaging, nucleotide resolution of single- stranded DNA has been achieved (Hansma et al. ( 1991b) /. Vac. Sci. Techn. B 9: 1282- 1284). AFM has also been used to image DNA fragments marked at specific locations with protein tags (Murray et al. (1993) Proc. Natl. Acad. Sci. USA 90:3811-3814). Nakagawa, U.S. 5,730,940 descnbes a scanning probe microscope which examines or processes directly the structure of surfaces at the atomic level, including a method for processing molecules and a method for detecting DNA base arrangement. DNA base aπangement is detecting using any one of three or four kinds of probes fixed with any one of four different kinds of molecules interacting with four kinds of bases compnsmg DNA, by approaching single stranded DNA fixed on a substrate, measunng the force and scanning by AFM at an atomic level of precision. Colton et al., U.S. 5,372,930 provide a sensor for ultra-low concentration of chemical recognition relying on a force transducer, a tip coupled to the force transducer and a substrate positioned for force interaction with the force transducer tip, where the substrate and tip are chemically modified with antigens, antibodies, nucleic acids, or chelating agents so that there is a specific force interaction between the tip and the substrate in the presence of the target species and a measurably different force interaction in the absence of the target species. Holzπchter et al., U.S. 5,620,854 disclose a method for identifying biochemical and chemical reactions and micromechanical processes using nanomechanical and electronic signal identification, i.e., STM or AFM. The method can be used to obsen e dynamic biological processes m real time and in a natural environment, such as polymerase processing of DNA for determining the sequence of a DNA molecule. Eigen et al. (1994) Proc. Natl. Acad. Sci. 97:5740-5747 review applications of single-molecule sorting in diagnostics and evolutional"} biotechnology. They disclose a method based on fluorescence conelation spectroscopy for detection and identification of single molecules in solution, including nucleic acid molecules. For detecting probe-target interactions, the method requires that the probe and target molecules be fluorescently labeled. The} do not descnbe library selection oi a single synthetic nucleotide molecule (e.g., an aptamer), nor do they contemplate the use and advantages of proximal probing techniques (e.g., SPM, STM, AFM) for directly measuπng binding properties and manipulating individual binding partners. Chan et al., U.S. 5,168,057 and U.S. 5,661,019 descnbe tnfunctional conjugates having three chemical moieties attached through a spacer moiety. At least two of the chemical moieties are relatively small molecules, usually less than about 7,000 daltons in size. The spacer moiety is selected to impart certain steπc properties to the conjugate. The utility of nucleotide-based molecular scaffolds as positioning devices is neither descnbed nor reasonably contemplated. There remains a need in the art for methods to select single synthetic nucleotide molecules with desired recognition and/or positioning properties for incorporation into useful products (e.g., multimolecular devices and drug deliv ery systems), to provide multimolecular devices compnsmg the selected synthetic nucleotide molecules, and to prepare nonnucleotide impπnts and mimetics of these nucleotide-based multimolecular devices for use in different environments and applications. Objects of the Invention An object of the present invention is to provide synthetic heteropolymers which compnse a first synthetic defined sequence segment capable of specifically recognizing and covalently attaching a first selected nonoligonucleotide molecule and a second defined sequence segment attached to the first synthetic defined sequence segment with the proviso that the second defined sequence segment is not a fixed, unconjugated pnmer-annea ng sequence. The first and second defined sequence segments may be attached directly or via a nucleotide spacer. The first selected nonoligonucleotide molecule recognized by the first synthetic defined sequence segment may compnse a specific binding partner of the first synthetic defined sequence segment or a specifically attractive surface feature. The second defined sequence segment is capable of specificalh recognizing a second selected nonoligonucleotide molecule such as a specific binding partner or specificalh attractive surface feature or specifically recogmzing a selected nucleic acid sequence. In this structure, the second defined sequence segment may also be capable of hybπdizing to a selected nucleic acid sequence or may compnse a conjugated defined sequence segment. Another object of the present invention is to provide heteropolymenc discrete structures which compnse a synthetic aptamer and a defined sequence segment which is attached to the synthetic aptamer and which is not a fixed, unconjugated pπmer-annealing sequence or a πbozyme. In these structures, the defined sequence segment may compnse an aptamer, a nucleotide sequence which specificalh binds or hybndizes to a selected nucleic acid sequence, or a conjugated defined sequence segment The defined sequence segment can be attached direct!} to the synthetic aptamer or v la a nucleotide spacer. Another object of the present inv ention is to provide molecular adsorbents which compnse a solid phase and a multivalent template having a first specific recogmtion element specificalh attached v ia the first specific recognition element to the solid phase. The solid phase compnses an amphibious or specificalh attractiv e surface. It is prefened that the multivalent template of the molecular adsorbent have at least one other second specific recognition element capable of specificalh recogmzing a selected nonoligonucleotide molecule or of specifically hybπdizing a selected nucleic acid sequence. Another object of the present invention is to provide multimolecular adherents which compnse a specific recognition element and a first selected molecule attached to the specific recogmtion element. The specific recogmtion element specificalh attaches, via specific binding or shape-specific recogmtion, the first selected molecule to a second selected molecule of an amphibious or specificalh attractive surface. Thus, in one embodiment the second selected molecule comprises a specific binding partner of the specific recognition element while in a second embodiment, the second selected molecule compnses a specificalh attractiv e surface feature. Another object of the present invention is to provide multimolecular adhesiv es which compnse at least two specific recogmtion elements capable of specificalh' attaching and joining at least two surfaces. At least one of the specific recognition elements of the molecular adhesive specifically recogmzes an amphibious or specifically attractive surface. Specific recogmtion of the specific recogmtion element ma} result from specific binding of the recogmtion element to a selected molecule of an amphibious surface, specific recognition of a surface feature of a specifically attractive surface or hybπdization to a nucleic acid sequence immobilized to the amphibious or specificalh attractive surface. Another object of the present invention is to provide multivalent heteropolymenc hybnd structures which compnse a first synthetic heteropolymer hybπdizably linked to a second synthetic heteropolymer. Each synthetic heteropolymer of this structure compnses at least two defined sequence segments. At least one defined sequence segment of the first synthetic heteropolymer specifically recogmzes a selected nonoligonucleotide molecule which may be a specific binding partner of this defined sequence segment or a specifically attractive surface feature specifically recognized b} this defined sequence segment. In one embodiment of this structure, at least one defined sequence segment of the second synthetic heteropolymer either specifically recogmzes a selected nonoligonucleotide molecule such as a specific binding partner of this defined sequence segment or a specificalh attractive surface feature specificalh recogmzed by this defined sequence segment or specificalh binds a selected nucleic acid sequence. In another embodiment of this structure, at least two defined sequence segments of the second synthetic heteropolymer h}bπdιze to selected nucleic acid sequences. At least one defined sequence segment of the second s}nthetιc heteropolymer ma} also compnse a conjugated defined sequence segment Another object of the present invention is to prov ide aptamenc multimolecular devices which compnse a nonaptamenc specific recognition pair and a synthetic aptamer which specifically binds or shape-specifically recogmzes an aptamer target wherein a member of the nonaptamenc specific recognition pair is conjugated to the aptamer to form a conjugated aptamer. In a prefened mode of operation, the conjugated aptamer positions the aptamer target for functional coupling with a member of the nonaptamenc specific recognition pair. It is prefened that the conjugated aptamer or the aptamer target compnses an effector molecule. In one embodiment, the nonaptamenc specific recognition pair compnses a nucleotide ligand or a nucleotide receptor. The aptamer target may compnse a specific binding partner of the synthetic aptamer or a surtace ieature oi a specifically attractiv e suriace. Another object ot the present invention is to prov ide tethered specific recogmtion devices which compnse a molecular scaffold and at least two members ot a specific binding pair or shape-specific recognition pair. The members of the specific binding pair or shape- specific recogmtion pair are covalently or pseudoiπeversibh attached to the molecular scaffold. The members of the specific binding pair or shape-specific recogmtion pair ma} also be specifically and directly attached to each other. It is prefened that at least one member of the specific binding pair or shape-specific recognition pair compnse an effector molecule. The molecular scaffold of the tethered specific recognition device may compnse a nonnucleotide molecule or a replicatable nucleotide. One or more members of the specific binding pair or shape-specific recognition pair of this device ma} also compnse an aptamer. Another object of the present invention is to pro ide tethered specific recogmtion devices which compnse a molecular scaffold and at least four members of two specific recogmtion pairs. Each member of the specific recogmtion pairs is covalently or pseudomev ersibly attached to the molecular scaffold of the dev ice. In this device at least one of the two specific recognition pairs compnses a specific binding pair, a shape-specific recogmtion pair or hybπdizable selected nucleic acid sequences. Further, specific attachment of the two members of one specific recognition pair precludes specific attachment of the two members of another pair. Another object of the present invention is to provide paired specific recogmtion devices which compnse a nucleotide-based molecular scaffold and at least two different specific recogmtion pairs conjugated to the molecular scaffold. At least one specific recognition pair of this device is capable of specific binding or shape-specific recognition and it is prefened that at least one member of one of the two specific recognition pairs compnse an effector molecule. The molecular scaffold preferabh compnses a replicatable nucleotide. The molecular scaffold of this device is preferabh capable of positiomng the specific recognition pairs for functional coupling between at least two members of the at least two specific recognition pairs. At least one member of the two specific recognition pairs may compnse an aptamer. In one embodiment of the paired specific recognition device at least one member of the at least two specific recogmtion pairs is specifically and directly attached to its specific recognition partner. Another object of the present invention is to provide a nonaptamenc multimolecular device which compnses a conjugated defined sequence segment and at least two different specific binding pairs or shape-specific recogmtion pairs. In this de ice, one member of each pair is conjugated to the conjugated defined sequence segment. The conjugated member of at least one of the pairs may compnse a modified nucleotide, a nucleotide ligand or nucleotide receptor. The conjugated defined sequence segment of this device is capable of positiomng the specific binding pairs or shape-specific recognition pairs for functional coupling between at least two members of the pairs. Another object of the present invention is to provide multimolecular drug delivery systems which compnse a multimolecular structure selected from a group consisting of aptamenc multimolecular devices, heteropolymenc discrete structures, multivalent heteropolymenc hybnd structures, synthetic heteropohmers, tethered specific recogmtion devices, paired specific recognition devices, nonaptamenc multimolecular devices, multivalent impnnts, and immobilized multimolecular delivery systems wherein the multimolecular structure contains a synthetic receptor that specifically recognizes a drug or a selected target. Another object of the present invention is to provide immobilized multimolecular structures which compnse a solid support and a multimolecular structure immobilized to the solid support wherein the multimolecular structure is selected from the group consisting of aptamenc multimolecular devices, heteropolymenc discrete structures, multivalent heteropolymenc hybnd structures, synthetic heteropolvmers, tethered specific recogmtion devices, paired specific recognition devices, nonaptamenc multimolecular devices, multivalent molecular structures, multivalent impnnts, and multimolecular drug delivery svstems. Another object of the present invention is to provide shape-specific probes which compnse a nucleotide-based or nonnucleotide recogmtion element capable of recogmzing a specifically attractive surface feature. Preferably, the recogmtion element compnses an aptamer, a nucleotide ligand or nucleotide receptor, or a selectable nonoligonucleotide molecule. Another object of the present invention is to provide multivalent impnnts of multimolecular structures which compnse at least two specific recognition elements impnnted from the multimolecular structure. Multimolecular structures for preparation of these impnnts may compnse aptamenc multimolecular devices, heteropolymenc discrete structures, multivalent heteropolymenc hybnd structures, s}nthetιc heteropohmers, or nonaptamenc multimolecular devices. In one embodiment of the multivalent impnnt, the impnnted specific recognition elements from the multimolecular structure mimic the specific recognition elements of the multimolecular structure. In another embodiment, the impnnted specific recognition elements from the multimolecular structure are capable of specificalh recognizing the specific recogmtion elements of the multimolecular structure. Another object of the present invention is to provide paired nucleotide-nonnucleotide mapping libranes which compnse a plurality of selected specific recogmtion partners capable of transposing a selected population of selected nonoligonucleotide molecules into replicatable nucleotide sequences. Another object of the present invention is to provide methods for selecting a single synthetic nucleotide molecule capable of recogmzing a labeled or unlabeled selected target molecule compnsing detecting a signal resulting from the proximit} or functional coupling between the single s}nthetιc nucleotide and the selected target molecule. In this method, it is prefened that the single synthetic nucleotide be selected from a nucleotide library It is also prefened that the single s}nthetιc nucleotide molecule compnse a molecule selected from the group consisting of an aptamer, a nbozyme, a catalytic nucleotide, a catalytic DNA molecule, a nucleotide catalyst, a nucleotide ligand and a nucleotide receptor The single synthetic nucleotide molecule may compnse an aptamer that specificalh recognizes the selected target molecule and is capable of forming a single discrete structure compnsing the aptamer and the selected target molecule or an aptamer-effector conjugate that specificalh recogmzes the selected target molecule and is capable of forming a single discrete structure compnsing the aptamer-effector conjugate and the selected target molecule while the selected target molecule may compnse an effector molecule. In one embodiment, the single synthetic nucleotide molecule compnses a catalytic nucleotide such as a nbozyme, a catalytic DNA molecule or a nucleotide catalyst. In another embodiment, the single synthetic nucleotide molecule compnses a shape-specific probe that specifically recogmzes a surface feature of a specifically attractive surface. In this method the signal may be detected by a vaπety of techniques including, but not limited to, optical microscopy, flow cytometry or detection of a photon emitted by a signal-generating species. In a prefened embodiment, the signal is detected b} single-molecule detection v la scanning probe microscopy. These methods ma} further compnse amplification of the selected single s}nthetic nucleotide molecule or nucleotide sequence determination of the selected single s}nthetic nucleotide molecule. Another object of the present invention is to provide methods for identifying a specificalh attractive surface feature which compnses contacting a surface library with a selected shape-specific recogmtion partner and detecting attachment of the selected shape- specific recogmtion partner to a specifically attractive surface feature of the surface libran . In a pretened embodiment, the shape-specific recogmtion partner is detectabh labeled and attachment is detected bv single-molecule detection. Summary of the Invention The instant invention descnbes nucleotide-based and nonnucleotide multimolecular structures and multimolecular devices capable of positiomng at least two specific recogmtion pairs (e.g.. a pair of specific binding pairs, optionalh including at least one shape recogmtion pair) within close spatial proximit} (i.e., within iunctional coupling distance). Disclosed herein are molecular templates compnsing, impnnted from and/or mimicking multiv alent nucleotides capable oi positioning and functionalh coupling multiple nucleotide or nonnucleotide molecules, at least one being a selected nonoligonucleotide molecule, to provide nucleotide-based and nonnucleotide multimolecular switches, multimolecular transducers, multimolecular sensors, molecular delivery systems, drug delivery systems, tethered recognition devices, molecular adsorbents, molecular adhesives and molecular adherents. Commercial applications include, e.g., therapeutics, diagnostics, cosmetics, agnceuticals, nutraceuticals, industnal matenals, consumer electronics, molecular-scale battenes, packaging, environmental remediation, sensors, transducers and actuators tor aeronautic and military use, smart pohmers, adsorbents, adhesiv es, adherents, lubncants. biomimeticalh functionalized organic and inorganic semiconductors and carbon- based, silicon- based and gallium arsemde-based membranes, devices and s} stems Nucleotide-based templates can be designed to recognize structural molecules compnsing, e.g., surfaces, parts, products and packaging matenals for use as willfully reversible and reusable molecular adhesiv es, adherents and adsorbents), and even biological surfaces. For example, template-directed delivery of selected molecules to keratin compnsing hair and nails enables precise and specific, willfully reversible, application of safe, lasting, yet reversible cosmetic dyes, pigments, liners and structural elements. Selection of ligands, receptors, aptamers and shape recogmtion partners from diverse sequence, chemical and shape recogmtion hbranes enables novel cosmeceutical formulations capable of specificalh decorating, strengthening, protecting, lengthening and thickening hair, nails, eyebrows and eyelashes. Templates compnsing, e.g., synthetic heteropolvmers and multimolecular devices ma} also be used as dopants, additives, active ingredients or smart polymers compnsing commercial chemicals, matenals, products and packages, particularly polymers, gels, foams, woven and nonwoven fibers, plastics, papers, rubbers, coatings, covenngs, paints, powders, sealants, adhesives and even recycled matenals, particularh as smart polymers capable of performing useful functions. Useful functions include, for example, stimulus- responsive molecular delivery, switching, sensing, transducing, and actuating changes in the internal or external environment or, alternativeh , in the properties of the host matenal (e.g., shape, color, temperature, conductivity, porositv, ngidit}. adhesiveness, odor). The ability to lntimateh combine within a single mulumolecular structure at least two specific recognition pairs with different specificities (i.e . ith control over the relative positions of or distance between constituent molecules) enables the design and construction of molecular-scale devices including multimolecular switches, sensors, transducers, molecular deliver}' systems, adsorbents, adherents, adhesi es and lubricants Multivalent molecular structures of the instant invention enable controlled positioning and optionalh covalent crosshnking oi multiple specific recognition pairs within suitable intermolecular proximit} to provide iunctional coupling between members oi the recogmtion pairs. Selected effector molecules can be conjugated to defined positions ot nucleotide or nonnucleotide scaffolds to enable both controlled intermolecular positiomng and functional coupling of conjugated effector molecules and recogmtion pairs Selected molecules positioned by specific recognition using affinity-based templates can subsequently be permanently or pseudoineversibly attached to one another or to the template using well known chemical and enzymatic methods, e.g., covalent crosshnking reagents, hgases and synthetases Alternativeh, template-ordered molecules can be used as impnntable hosts ior cast-and- mold pnnting of nonnucleotide (e.g., plastic) templates and assemblies shaped by templated guest molecules Two members oi a specific binding or shape recogmtion pair or even two different specific recogmtion pairs can be tethered b} pseudoinev ersible (e.g., covalent, avidin biotin-based, or hybndization-based) incorporation w ith a nucleotide-based. aptamenc, heteropolymenc or nonnucleotide device in such manner that specific binding and unbinding between covalently connected molecules provides a useiul, potentialh reversible function (e.g., stimulus-responsive binan switching) without dissociative or diffusional loss or dilution oi participating binding partners. The same tethenng pnnciple is applied in hybndization-based multimolecular switches compnsing two (or more) pairs of complementary defined sequence segments, all four constituent defined sequence segments being covalently attached to one another within a single discrete structure, wherein either one pair or the other is hybndized at any given time. Such tethered specific recognition devices may be nucleotide-based (i.e., relying on nucleotides for molecular positiomng), or they ma\ be constructed using a nonnucleotide scaffold, preierably a copolymer or heteropolymer or flexible polymer compnsing folds, bends, joints, hinges or branchpoints. Nucleotide-directed functional coupling between selected molecules or specific recogmtion pairs can be used as a screening and selection cntenon for identification of defined sequence segments with desired recogmtion properties. The present invention extends the teachings of Cubicciotti, U.S. 5,656,739 by providing specifically and optionally covalently assembled multimolecular structures and multimolecular devices compnsing MOLECULAR MACHINES. The term MOLECULAR MACHINES is used herein to descnbe claimed compositions and methods oi the instant invention, including aptamenc multimolecular devices, heteropolymenc discrete structures, multimolecular deliver}' systems, multivalent molecular structures, molecular adsorbents, multimolecular adherents, multimolecular adhesives, multivalent heteropoh menc hybnd structures, synthetic heteropolvmers, tethered specific recognition devices, paired specific recognition devices, nonaptamenc multimolecular devices, multivalent impnnts, multimolecular drug deliver} systems, shape-specific probes, paired nucleotide- nonnucleotide mapping hbraπes, paired nucleotide-nonnucleotide library-selected single synthetic nucleotides, paired nucleotide-nonnucleotide hbran -selected single synthetic nucleotide impnnts, immobilized multimolecular structures, specificalh attractive surface features, multimolecular switches, multimolecular sensors, multimolecular transducers, paired templates and paired MOLECULAR MACHINES. Importantly, the instant invention discloses methods and dev ices which transpose the useful products and properties descnbed by Cubicciotti, U.S. 5,656,739 into nonnucleotide multimolecular devices, including multivalent impnnts of nucleotide-based multimolecular structures and specifically recognizable surface features compnsing heretofore chemically bland, optionalh inorganic substrates, e.g., silicon and gallium arsemde. A vanetv of molecular-scale switches, sensors, transducers, molecular deliven systems and specific, willfulh reversible, adsorbents, adhesives and adherents are assembled from multivalent templates and scaffolds. The multivalent propert} of the templates prov ides control over the relative positions oi molecules within cooperative molecular assemblies compnsing useful multimolecular dev ices. Innovative properties and products are achieved by template-directed assembly of cooperative pairs and groups ot molecules. S}nthetιc heteropolvmers are particularly well-suited template matenals. This invention is not specifically drawn to the properties of the template matenal, itself, but to the wealth of useful dev ices that can be assembled by combining selected molecules withm a single multimolecular structure. A central inventive step of this disclosure is demonstration of the v anety of different dev ices that can be prepared by either 1 ) tethenng t o members of at least one specific binding or shape-specific recognition pair to a common molecular scaffold, so the recognition partners may exist in either of two states (e.g., specifically bound or dissociated) or 2) combining at least two different specific recogmtion pairs withm a single multimolecular structure, i.e., a pair of specific recognition pairs, each pair having two members. Combining a selected pair of selected specific recogmtion pairs within a single multimolecular structure provides a vast array of useful MOLECULAR MACHINES. Disclosed herein are multimolecular switches, multimolecular sensors, multimolecular transducers and multimolecular drug delivery systems prepared from paired specific recogmtion pairs, advantageously from multimolecular structures which can be impnnted or transposed between nucleotide and nonnucleotide molecular media via paired nucleotide- nonnucleotide hbranes. Multimolecular devices preferably compnse or mimic synthetic heteropohmers disclosed in Cubicciotti, U.S. 5,656,739 Nonnucleotide molecular scaffolds and templates are preferabh' bivalent, multivalent or heterofunctional molecules or pohmers prepared b} chemical, enzymatic and/or biological methods or mechanochemical synthesis, e.g., by nanomampulation using proximal probes (e.g., SPM). Precursors may be biological, nonbiological, natural or synthetic monomers, polymers and/or selected molecules. Mulumolecular drug deliver}' systems compnsing receptor-targeted prodrugs and tethered prodrug deliver} configurations, provide the art with highly specific control over drug action b\ combining prodrug compositions with receptor targeting, tnggered release and localized activation mechanisms. They are particularh useful, e.g., for improving safet} , targeting efficiency, compliance and efficacy for indications benefiting from single- dose, prolonged action or tissue-specific formulations, e.g., allergy, asthma, cancer, infection, vascular occlusion, psonasis, arthntis and fibrosis. Tethered specific recogmtion devices provide the benefits of specific recogmtion without the vanabi ty and limitations of diffusible binding partners. They are particularh useful, e.g., for molecular counting, search-and-destroy and sense-and-actuate applications, e.g., drug delivery and environmental remediation. Multimolecular adhesives prov ide the art with surface bonding products relying on specific binding, complementary base painng and specific surface attractivity. The\ are particularh useful, e.g., for precise bonding of micromachined and/or nanofabncated surfaces in proper register and for willfully reversible assembh of products and packages. Multimolecular adherents provide the art with products that specifically attach a selected molecule or molecular function to a selected structure or surface, advantageously in a willfully reversible manner. They are particularly useful, e.g., for feature-directed patterning of electroactive and photoactive molecules on semiconductors, CDs and DVDs; safe and rev ersible targeting of cosmetics to hair and nails; and site-specific repair of skin lπegulanties, scars, wnnkles and discolorations using target-directed cosmeceuticals, structural molecules and pigments. Molecular adsorbents provide the art with matenals and surfaces having specificalh attractive surface features, i.e., structural shapes capable of specifically recognizing and attaching selected molecules (i.e., ligands, receptors, structural molecules and effector molecules). They are particularly useful, e.g., as semiconductor substrates and separation media for industnal punfication and processing. The invention also provides the art with single-molecule selection methods that enable a heretofore unknown recognition property to be identified with single-molecule resolution from a highly diverse nucleic acid library, including isolation, charactenzation and sequencing of the individual selected nucleotide. Single-molecule selection methods are particularh useful, e.g., for selecting aptamenc and catalytic nucleotides for assembly of functionalh coupled multimolecular devices and MOLECULAR MACHINES of the invention. The invention also provides the art with a method for screening and selecting diverse nucleotide hbranes for functional coupling between a donor and an acceptor species. Selection based upon functional coupling is particularly useful, e.g., for identifying cooperative molecular interactions (i.e., energy transfer, enzyme channeling) that cannot be resolv ed with pnor art screening and selection methods. . The invention also provides the art with methods for transposing or impnnting nucleotide-based MOLECULAR MACHINES into diverse (i.e., plastic) nonnucleotide molecular media. Nucleotide-nonnucleotide impnnting and transposition are particularh' useful, e.g., for development of MOLECULAR MACHINES for industnal use, i.e., nonbiomedical applications. The invention also provides the art with a method to select a nucleotide-based mapping hbran capable of encoding the recognition properties of a selected population of selected nonnucleotide molecules in the form of a library of amplifiable nucleotide sequences. Mapping hbranes are particularh useful, e.g., for amplifying, archiving and monitonng the recogmtion properties of a clinically relevant population of selected nonnucleotide molecules, e.g., antibodies, disease markers or T cell antigens. Detailed Description of the Invention GLOSSARY The term "actuator" means a device or process capable of providing or performing useful work (i.e., a desirable result) in response to a stimulus, e.g., an input from a user, operator, system, environment, sensor or transducer, including, but not limited to, useful work resulting from, accompanying or mediated by the binding or activity of a nucleotide or nonnucleotide molecule compnsing or capable of attaching to a nucleotide-based or nonnucleotide multimolecular device. Actuators of the present invention include devices which compnse, attach, are functionally coupled to or are capable of functionally coupling to multimolecular structures, MOLECULAR MACHINES, paired MOLECULAR MACHINES and systems compnsing pairs, groups or networks of paired MOLECULAR MACHINES. "AFM" is an abbreviation for "atomic force microscopy." The term "amphibious surface" means a nonnucleotide surface that is able to operate in or on land, air, water, in a acuum, or in a gaseous, liquid, aqueous or organic fluid, solution, glass or suspension, or in any combination oi these environments, so long as the surface is not a reagent-binding or analyte-binding separation matnx oi a specific binding or nucleic acid hybndization assay or a molecular recogmtion site capable of specifically binding or hybndizmg a drug or hormone (i.e., a drug or hormone receptor or pathophysiological target). "Operate," when used in reference to an amphibious surface, means to perform a useful function. "Nonnucleotide surface.' 1 hen used in reference to an amphibious surface, means a surface that does not compnse a heretofore known nucleotide- based molecular recognition partner unless and until modified b} a multimolecular device of the instant invention. A nonnucleotide amphibious surface modified by attachment ot a nucleotide-based mulumolecular device of the instant invention remains an amphibious surface despite the attachment of nucleotides compnsing the multimolecular device. Amphibious surfaces are limited to nonnucleotide surfaces to distinguish molecular adherent- modified and molecular adhesive-modified surfaces of the instant invention from biological and nonbiological hybndizable surfaces (e.g., immobilized nucleic acid probes and targets, in situ biological nucleic acids, and biological recogmtion sites compnsing immobilized nucleic acids). Amphibious surfaces include, for example, surfaces of matenals, parts, packaging, packing matenals, people, products, vehicles, airports, train and bus stations, wholesale and retail establishments and media and communication systems used for research, development, manufacture, packaging, marketing, distnbution, sales and support of commercial goods and services. Also included are surfaces compnsing the homes, gardens, households, families and pets of consumers of commercial goods and services, excluding home or office testing product surfaces to which molecular recognition reagents are immobilized for use in specific binding or hybndization assays and further excluding immobilized or membrane-associated drug and hormone receptors that specificalh bind or hybndize to drugs or hormones. Docking surfaces of membrane-associated receptors for drugs and hormones that specifically bind or hybndize to pathophysiological targets are not amphibious surfaces, nor are solid supports compnsing diagnostic or analytical antibodies, antigens, DNA probes, drugs, hormones or hormone receptors immobilized on latex particles, ELISA plates, chromatography supports, electrophoretic gels, polystyrene beads or lmmunochromatographic membranes (e.g., in home pregnancy tests). B} contrast, the reagent surface of a home glucose test is an amphibious surface, as heretofore known home glucose tests do not compnse immobilized specific binding or hybndization reagents. A specifically attractive biological surface or structural shape is also an amphibious surface, so long as it is not a docking surface of a pathophysiological receptor that hybndizes or specifically binds a drug or hormone. The terms "amplify" and "amplification," when used in reference to a molecule, nucleotide, target, population or library, refer to methods, processes, reagents or devices for increasing the amount, mass, concentration, detectabihty or number of copies oi at least one molecule, group, sequence, member, subset or structure compnsing the molecule, nucleotide, target, population or library. The term "aptamer" means a single-stranded, partialh single-stranded, partially double-stranded or double- stranded nucleotide sequence, adv antageoush a replicatable nucleotide sequence, capable of specifically recogmzing a selected nonoligonucleotide molecule or group of molecules by a mechanism other than Watson-Cnck base painng or tnplex iormation. Aptamers disclosed herein include, without limitation, defined sequence segments and sequences compnsing nucleotides, ribonucleotides, deox}nbonucleotιdes, nucleotide analogs, modified nucleotides and nucleotides compnsing backbone modifications, branchpoints and nonnucleotide residues, groups or bndges. Aptamers of the invention include partialh and full} single-stranded and double-stranded nucleotide molecules and sequences, synthetic RNA, DNA and chimenc nucleotides, h}bπds, duplexes, heteroduplexes, and any nbonucleotide, deox}nbonucleotιde or chimenc counterpart thereof and/or conesponding complementan sequence, promoter or pnmer- annea ng sequence needed to amp f} , transcπbe or replicate all or part of the aptamer molecule or sequence. Unlike pnor art aptamers that specificalh bind to soluble, insoluble or immobilized selected molecules (e.g., ligands, receptors and effector molecules), the instant term "aptamer" includes nucleotides capable of shape-specific recognition of chemically bland surfaces by a mechamsm distinctly different from specific binding. Aptamers of the instant invention may be selected to specifically recognize a structural shape or surface feature compnsing a chemically bland surface (e.g., a silicon chip or carbon nanostructure) rather than the chemical identity of a selected target molecule (e.g., a ligand or receptor). An aptamer ma} be a molecule unto itself or a sequence segment compnsing a nucleotide molecule or group oi molecules, e.g., a defined sequence segment or aptamenc sequence compnsing a s}nthetιc heteropohmer, multivalent heteropohmenc hybnd structure or aptamenc multimolecular dev ice. The terms "aptamer-based" and "aptamenc" mean compnsing at least one s}nthetic aptamer The term "aptamer conjugate" means a conjugate compnsing an aptamer and a second molecule and includes aptamers compnsing nonnucleotide molecules or moieties introduced dunng as well as alter nucleotide synthesis, e.g., by incorporation of denvatized nucleotides. nucleosides or nucleoside phosphates, labeled nucleotides, modified nucleotides, biotinylated nucleotides, nucleotide ligands, nucleotide receptors, conjugated nucleotides, nucleotides denvatized with nonnucleotide ligands or receptors, nonnucleotide molecules and the like. An aptamer conjugate is referred to herein as a synthetic aptamer if the conjugate is not heretofore known to occur in nature, regardless of the nucleotide sequence compnsing the aptamer. The term "aptamenc device" means a discrete aptamenc structure capable of providing functional coupling between a selected molecule which is not an aptamer target, preferably a ligand or receptor or a molecule conjugated to a ligand or receptor, and a selected molecule which is an aptamer target, preferably an effector molecule and more preferably a signal-generating species or a drug. Aptamenc dev ices of the instant invention include multimolecular switches, multimolecular transducers, multimolecular sensors and multimolecular delivery systems compnsing synthetic aptamers or aptamer conjugates. The term "aptamenc discrete structure" means a discrete structure compnsing at least one aptamer. The term "aptamenc multimolecular complex" refers to a synthetic heteropolymer compnsing tw o different aptamer molecules directly attached or conjugated to one another or lndirecth attached via a linker (i.e., a nucleotide spacer, spacer molecule, ohgonucleotide linker or nonnucleotide linker) that joins the aptamers to form a discrete heteropolymenc structure capable of specifically recogmzing two different nonoligonucleotide molecules. The term "aptamenc multimolecular device" means a multimolecular device compnsing at least one synthetic aptamer compnsing a conjugated selected molecule which is not the aptamer target, preferably a conjugated nonaptamenc specific recognition pair compnsing a selected molecule capable of functional coupling with the aptamer target, preferabh' an effector molecule compnsing the aptamer target. The synthetic aptamer is capable of specifically recogmzing the aptamer target which preferably compnses an effector molecule so as to provide functional coupling between a selected molecule compnsing the conjugated nonaptamenc specific recogmtion pair and the aptamer target. The conjugated selected molecule may compnse a modified nucleotide, or it ma} be attached to a nucleotide compnsing the aptamer, preferably by direct and site-specific attachment. In a prefened embodiment, the conjugated selected molecule comprises a nucleotide ligand or nucleotide receptor, i.e.. a nucleotide library-selected modified nucleotide capable of specifically binding or shape-specifically recogmzing a selected target which is not the aptamer target. In this vva\, the aptamenc multimolecular device compnses at least two nucleotide library- selected recognition elements which specifically recognize two different selected molecules, i.e., an aptamer which specifically recogmzes an aptamer target and a nucleotide ligand or receptor which specifically recogmzes a selected molecule or a surface feature of a specificalh attractive surface. Advantageously, the conjugated selected molecule (i.e., first conjugated selected molecule) is indirectly attached to the aptamer, e.g., by specific recognition of a second conjugated selected molecule which is directly and preferably site- specifically and covalently attached to a nucleotide compnsing the aptamer. In this mode of operation, the aptamenc multimolecular device compnses a paired specific recogmtion device, wherein the first and second conjugated selected molecules compnse a first specific recogmtion pair and the synthetic aptamer and its selected target molecule compnse a second specific recogmtion pair. The aptamenc multimolecular device is advantageously capable of positiomng a member of one specific recognition pair for functional coupling with a member of another specific recognition pair. At least one member of at least one specific recogmtion pair of an aptamenc multimolecular device preferably compnses an effector molecule, more preferabh a drug or a signal-generating species. An aptamenc multimolecular device preferabh compnses at least one replicatable nucleotide sequence. The term "aptamenc tethered specific recogmtion device" means an aptamenc multimolecular device having two members of a nonaptamenc specific recogmtion pair conjugated to an aptamenc molecular scaffold. At least one member of the aptamenc and/or nonaptamenc specific recognition pair preferably compnses an effector molecule, e.g., the member is detectably labeled or specifically attached to a releasable or activatable effector (e.g., a prodrug or a signal-generating species). The terms "aptamer target," "target," and "selected target," when used in reference to aptamer-target binding, means a selected molecule, group of molecules or surface feature specificalh recognized by an aptamer. The terms "aptamer" and "aptamer target" as used herein are distinguished from "ligands" and "receptors." Although an aptamer and its target are specific binding partners and members of a specific binding pair, they are not refened to herein as ligands and receptors. The inventor's lexicograph} in this regard is intended to avoid conflict and contradiction arising from inconsistency and/or ambiguity in pπor art usage of the terms ligand and receptor with respect to nucleic acids and aptamers. For example, the terms "nucleic acid ligand" "nucleic acid receptor," "nucleic acid antibody" and "aptamer" are sometimes used interchangeably or lnclusiveh in the art, often without explicit, precise or commonly accepted definitions. The terms "aptamer," "ligand," "receptor" and "bispecific nucleic acid antibody" are independently and autonomoush defined herein to avoid misinterpretation of the instant specification is-a- is pπor art terminolog} . The term "assortment" means a plura t} compnsing at least two different members. The term "attachment site" refers to covalent and/or noncovalent site-directed attachment bv methods including, but not limited to, specific recognition and site-specific chemical modification.. The terms "bifunctional," "tπfunctional" and "multifunctional," when used in reference to a synthetic heteropolymer or multivalent heteropolymenc hybnd structure, mean bivalent, tπv alent or multivalent, as the case may be, or compnsing two, three or multiple specific recogmtion elements, defined sequence segments or attachment sites. When used in reference to a multivalent heteropolymenc hybnd structure, the terms "bifunctional," "tπfunctional" and "multifunctional" refer to the number of available and/or unoccupied specific recognition sites, excluding the hybridized sequences joining the constituent synthetic heteropolvmers. When used in reference to a molecule, linker or crosshnking reagent, the terms "bifunctional," tnfunctional" and "multifunctional" are used to descnbe the number of functional, chemical or reactive groups. The terms "binding domain" and "recogmtion domain." when used in reference to a molecule or group of molecules, mean the portion or region of the molecule or group of molecules which is directly involved in binding or recogmtion. The terms "binding element," "recognition element" and "element," when used in reference to a specified activity, recognition property or docking surface of a molecule, group, segment, template, scaffold, multimolecular structure or impnnt, mean the operativ e site, region, epitope, binding domain, catalytic domain, selected molecule, defined sequence segment or nucleotide compnsing the specified activity, recogmtion property or docking surface The term "binding partner" means a member of a specific recogmtion pair, each member oi the specific recognition pair being a binding partner oi the other member The term "biocompatible" means an exogenous substance that is relativeh nonimmunogemc, nonallergemc and nontoxic when administered, contacted or attached to a biological organism. The term "biological recogmtion site" means a catahtic site, h}bndιzatιon site or specific binding site compnsing a member of a heretofore kno n recognition pair whose members are biological molecules or biological nucleic acid sequences. A biological recogmtion site is the operative recogmtion site of a first biological molecule or biological nucleic acid sequence heretofore known to be a molecular recogmtion partner or catalytic recogmtion partner oi a second biological molecule or biological nucleic acid sequence. The term "biomimetic" means a nucleotide-based or nonnucleotide molecule, group, multimolecular structure or method that mimics a biological molecule, group oi molecules, structure, s}stem, process or pnnciple, i.e., a mimetic oi a biological composition, process or pnnciple. The teπn "bispecific nucleic acid antibod}" means a bivalent or multivalent aptamenc device, synthetic heteropolymer or multimolecular deuce which is capable of specifically recogmzing at least two different target molecules. The term "bivalent," when used in reference to nucleotide-based, aptamenc and heteropolymenc discrete structures and nonnucleotide multimolecular structures, templates, scaffolds and molecules, means compnsing at least two recognition sites or, in certain instances, precisely two specific recogmtion sites. When used in reference to a multivalent heteropolymenc hybnd structure, the terms "bivalent" and "bifunctional" mean preciseh two defined sequence segments capable of specific recogmtion, excluding the hybπdized sequences joining the constituent synthetic heteropolvmers. In general, the term "bivalent" means at least bivalent and includes multivalent and multifunctional compositions, e.g., multivalent multimolecular structures. The term "bivalent impnnt" means a multivalent impnnt compnsing at least two recognition elements and optionalh precisely two recognition elements. The term "catalytic recogmtion partner" refers to a molecule or group of molecules capable of interacting selectively in a catalytic or enzymatic reaction, i.e., a reaction involving the making or breaking of covalent bonds which can be accelerated, facilitated, enhanced, modulated or practically enabled by a natural or synthetic enzyme or catalyst. Selective interaction means that a molecule preferentially modulates the activity of a particular enzyme or catalyst relative to other molecules in a reaction mixture or that catalytic or enzymatic activity is modulated by relatively low concentrations of the molecule, preferably less than about milhmolar concentrations. Molecules capable oi selective interaction in catalytic and enzymatic reactions include, without limitation, catahsts, enz}mes. nbozymes, catalytic DNA. nucleotide catalysts, enzyme substrates, products, intermediates, coenzymes, cofactors, prosthetic groups, coordinated and chelated groups, regulatory factors, steπc and allostenc modulators, inhibitors, mediators, and the like. Catalytic recogmtion partners include, without limitation, protein and nonprotein, nucleotide and nonnucleotide, organic and inorganic, specific, relativeh unspecific and class-specific enz}mes, catalysts, substrates, coenzymes, cofactors, inhibitors, regulatory factors and mimetics, impnnts and conjugates thereoi and progeny therefrom. The term "catalytic recogmtion site" refers to a recogmtion site compnsmg a catalytic recogmtion partner, i.e., a molecule or group of molecules that interacts selectively in a catalytic or enzymatic reaction. The term "chemically bland," when used in reference to a substance, structure, surface or matenal, means a composition compnsing a nonbiological, s}nthetιc, nonliving, planar or flat surface that is not heretoiore known to compnse a specific binding, h}bπdιzatιon or catalytic recogmtion site or a plurality of different recognition sites or a number oi different recognition sites hich exceeds the number ot diiferent molecular species compnsing the surface, structure or matenal. Chemicalh bland surfaces, structures and matenals include, for example and without limitation, semiconductors, synthetic (organic) metals, synthetic semiconductors, insulators and dopants; metals, allo}s, elements, compounds and minerals; s}nthetιc, cleaved, etched, lithographed, printed, machined and microfabncated slides, substrates, devices, structures and surfaces; industnal polymers, plastics, membranes and substrates; silicon, silicates, glass, metals and ceramics; wood, paper, cardboard, cotton, wool, cloth, woven and non woven fibers, matenals and fabπcs; and amphibious surfaces, solid supports, nanostructures and microstructures unmodified b} immobilization of recognition molecules. The term "complementaπty," when used in reference to nucleotides. means the stability, melting temperature or number, type or percent of complementan base pairs compnsing a defined sequence segment, complementary sequence, duplex or hybπdized pair of sequences, e.g., the length, number of base pairs, number of complementan' nucleotides, percent base paiπng or G-C content compnsing a defined sequence segment. The teπn "complex," when used in reference to a pair or group of molecules, means at least two molecules attached to one another either rev ersibly, quasirev ersibly or pseudoineversibh . The term "conjugate" means two or more molecules, at least one being a selected molecule, attached to one another in an lneversible or pseudoineversible manner, typically b} covalent and/or specific attachment. A first selected molecule may be conjugated to a second molecule or to a nucleic acid sequence either mdirecth, e.g., through an intervening spacer arm, group, molecule, bndge, earner, or specific recogmtion partner, or directly, i.e., without an inten ening spacer arm, group, molecule, bndge, earner or specific recognition partner, advantageously by direct covalent attachment. A selected molecule may be conjugated to a nucleotide v la hybridization, provided the selected molecule is tagged with an o gonucleotide complementary to a selected nucleic acid sequence compnsing the nucleotide. Other noncovalent means for conjugation of nucleotide and nonnucleotide molecules include, e.g., ionic bonding, h}drophobιc interactions, ligand-nucleotide binding, chelating agent/metal ion pairs or specific binding pairs such as av ldin/biotin, streptav ldm/biotin, anti-fluorescein/fluorescein, antι-2,4-dιnιtrophenol (DNP)/DNP, anti- peroxidase/peroxidase, anti-digoxigenin/digoxigenm or, more generalh, receptor/ligand. For example, a reporter molecule such as alkaline phosphatase, horseradish peroxidase, β- galactosidase. urease, luciferase, rhodamine, fluorescem, phycoerythnn, luminol, isoluminol. an acπdimum ester or a fluorescent microsphere which is attached, e.g., for labeling purposes, to a selected molecule or selected nucleic acid sequence using av ldin/biotin. streptavidin/biotin, anti-fluorescein/fluorescein. anti-peroxidase/peroxidase. anti-DNP/DNP, anti-digoxigemn/digoxigemn or receptor/ligand (i.e., rather than being directh and cov alenth attached) is said to be conjugated to the selected molecule or selected nucleic acid sequence b} means of a specific binding pair. The term "conjugate" does not include an unmodified sequence of nucleotides, refened to herein as a molecule, nucleic acid, nucleotide, defined sequence segment, nucleotide sequence or ohgonucleotide. However, oligonucleotides, aptamers, synthetic heteropolvmers, defined sequence segments and selected nucleic acid sequences may be refened to as conjugates if a nonnucleotide molecule, group or moiety (e.g., biotin, digoxigenin, fluorescem, rhodamine) is introduced as a nucleotide analog, modified nucleotide or nucleoside tπphosphate before, dunng or after nucleic acid synthesis. When used in reference to a first defined sequence segment or selected nucleic acid sequence attached to a second defined sequence segment or selected nucleic acid sequence, the terms "conjugation," "conjugate" and "conjugated" refer to covalent attachment. A pair or group of hybndized and or specifically bound nucleic acids or nucleotide sequences is not referred to herein as a conjugate. The term "conjugated aptamer" means an aptamer conjugate, e.g., an aptamer conjugated to a selected molecule or an aptamer compnsing a conjugated nucleotide. The terms "conjugated selected molecule" and "conjugated molecule," when used in reference to a defined sequence segment, also refened to herein as a "conjugated defined sequence segment," means either 1) a selected molecule or nonnucleotide molecule covalenth or pseudoirreversibly attached to a defined sequence segment or 2) a defined sequence segment compnsing a selected molecule or nonnucleotide molecule, e.g., a denvatized or modified nucleotide, nucleoside phosphate, nucleotide analog, nucleotide ligand or nucleotide receptor compnsing a nonnucleotide molecule. Where a conjugated first defined sequence segment of a bifunctional synthetic heteropolymer or multivalent heteropoh menc hybnd structure is used to position a first selected molecule (i.e., the conjugated molecule) for functional coupling with a second selected molecule, the first and second selected molecules are different molecules and do not compnse a pseudoineversibh or cov alenth attached ligand-receptor pair. In other words, a deiined sequence segment and a conjugated defined sequence segment of a bifunctional synthetic heteropolymer or multi alent heteropolymenc hybnd structure are not directh attached (i.e., without lntenening nucleotide or nonnucleotide molecules) to the same selected molecule or covalent or pseudoinev ersible ligand-receptor conjugate. The two defined sequence segments directh attach to two different molecules whose assembly (i.e., attachment within a single discrete structure) is brought about by the molecular positiomng property of the synthetic heteropoh mer or multivalent heteropolymenc hybnd structure. Conjugated defined sequence segments ma} be produced by conventional nucleic acid s}nthesιs using modified or denvatized nucleotides (e.g., using biotin, fluorescem, psoralen or acndine phosphoramidites) or by enzymatic labeling (e.g., using the modified nucleoside tnphosphates biotin- 11 -dUTP, biotin- 14-dATP or 8-amιnohexyl-dATP) or chemical modification (e.g., using a diamine, bis-hydrazide or heterobifunctional crosshnker) of a defined sequence segment. The term "conjugated defined sequence segment" does not mean or include a defined sequence segment hybπdized to a selected nucleic acid sequence, unless the unh}bπdιzed selected nucleic acid sequence or defined sequence segment is conjugated to a selected molecule. In other words, hybndized nucleotides sans attached nonnucleotide molecules are not refened to herein as conjugates. To position a conjugated selected molecule for functional coupling to a selected molecule specifically bound to a different defined sequence segment, 3' and/or 5' end-labeling of a defined-length sequence is preferred, particularly 5'-end labeling. The efficiency of functional coupling can then be optimized by varying the length, and optionally the composition, of the conjugated defined sequence segment. Defined sequence segments internally labeled or modified at defined nucleotide positions can also be used to effectively position conjugated selected molecules, as functional coupling can be optimized by varying the conjugation position. Conjugated defined sequence segments are synthetic defined sequence segments. In other words, a conjugated defined sequence segment is considered synthetic, regardless of the nucleotide sequence of the unconjugated nucleotide. The terms "conjugated specific binding pair," "conjugated specific recogmtion pair" and "specific binding pair conjugate," when used in reierence to a specific binding or shape recognition pair conjugated to a defined sequence segment, selected nucleic acid sequence, plastic segment, template, molecule or molecular scaffold compnsing a multimolecular structure, mean at least one member ot the specific binding or shape recogmtion pair, optionally an aptamer, is conjugated to the multimolecular structure b} covalent or pseudoirreversible attachment. The other member oi the pair is either specificalh bound (or specifically attached) or capable of specifically binding (or specifically attaching) to its conjugated specific binding partner (or structural shape recogmtion partner). For example, w hen one member of a specific binding pair is conjugated to a segment, template or scaffold compnsing a multimolecular structure, the specific binding pair is refened to as conjugated to the multimolecular structure it and hen both members of the specific binding pair are specifically bound to one another or present and available for specific binding to one another. An aptamer-target pair compnsmg an aptamenc or heteropoh menc multimolecular device is a conjugated specific binding pair, provided the aptamer or aptamer target is covalently or pseudoirreversibly attached to a molecule or scaffold other than its binding partner, e.g., a nucleotide compnsing a second defined sequence segment of a synthetic heteropolymer. When used in reference to a nucleotide-based or nonnucleotide multimolecular device, "conjugated specific binding pair," and "specific binding pair conjugate," mean that operation of the multimolecular device requires the presence of both members of the specific binding pair or, in the case of certain analyte-dependent sensors or target-dependent molecular deliver} systems, that the device does not respond to a stimulus or deliver its payload until both members oi the specific binding pair are present. In either case, a nucleotide-based or nonnucleotide multimolecular device is said to compnse a specific binding pair if and onh if a useful function is performed by the device hen both members of the specific binding pair are present and available for specific binding. Hybndized nucleic acid sequences are not considered to be conjugated to one another, nor is a nucleic acid target considered to be conjugated or pseudoinev ersibly attached to a nucleic acid probe. In other words, the term "conjugated specific recognition pair" does not mean or include a pair of hybndized nucleic acid sequences, i.e., a duplex or double-stranded nucleotide. Hybndization may be used to pseudoirreversibly conjugate an ohgonucleotide- tagged selected nonoligonucleotide molecule to a nucleotide sequence, provided the ohgonucleotide tag and nucleotide sequence compnse complementary sequence segments. However, the hybndized selected molecule-nucleotide product is refened to as a "conjugated selected molecule" or "conjugated defined sequence segment," not a conjugated specific recognition pair. The terms "cooperating," "cooperative interactions" and "cooperativit}," when used to descnbe molecules and the interactions between and among molecules, mean proximity-dependent intermolecular ork or energy transfer and refer either to the ability of selected nucleotide or nonnucleotide molecules to interact positively or negatively to produce a desired result or to an effect on one molecule created by the presence ot a second molecule or to an action or effect brought about by the proximity of t o or more molecules or to the combined actions of two or more molecules on a third molecule or to a chemical, electncal, optical, thermal, mechanical, energetic or informational transformation of a system brought about b} the additive or synergistic activities of at least two positionalh controlled molecules. Cooperativity includes functional coupling bet een or among two or more molecules, reactions or processes. The terms "defined position," "defined nucleotide position" and "positionally defined," when used in reference to a nucleotide sequence, mean an identified nucleotide, nucleotide analog, modified nucleotide, monomer, residue, f unctional group, recognition site or attachment site at the Nth monomer of a defined sequence segment or a plurality of identified nucleotides compnsing a defined sequence segment beginning at the Nth monomer of a nucleotide sequence, where "N" is an integer representing the number of monomers from one end ot the nucleotide sequence to the identified nucleotide or defined sequence segment. Defined sequence segments and selected nucleic acid sequences ot the instant invention may be labeled or modified at defined positions b} site-specific, site -directed and/or regiospecific attachment, conjugation and modification methods known in the art, including synthesis of oligonucleotides with modified nucleotides, conjugated nucleotides, nucleotide analogs and spacer modifiers at operator-specified positions. Umformh, randomh or arbitranh labeled or modified nucleotides are not considered herein to be labeled or modified at defined positions, i.e., they are not considered posmonalh defined nucleotides. The term "defined sequence segment" means a selected, designed or identified sequence ot nucleotides and includes single-stranded, double-stranded, partialh smgle- stranded and partialh double-stranded biological and s}nthetιc nucleotide sequences, advantageoush replicatable nucleotide sequences. When used in reference to synthetic heteropolvmers of the instant invention, the term "defined sequence segment" refers to either 1) a nucleotide sequence having a defined number of nucleotides or 2) a nucleotide sequence compnsing a nucleotide analog, modified nucleotide or conjugated nucleotide at a defined position or 3) a synthetic ohgonucleotide or 4) a selected aptamer or 5) a selected, modified or designed sequence of monomers, preferably a single-stranded or double-stranded sequence of nucleotides, which is capable of specifically binding to an identified molecule or group of molecules or a selected nucleic acid sequence or of hybndizing to a selected nucleic acid sequence or of positiomng a conjugated selected molecule or specific binding pair for single-molecule detection and or functional coupling to a different molecule or specific binding pair. Defined sequence segments of the invention include partially and fully single- stranded and double-stranded nucleotide molecules and sequences, synthetic RNA, DNA and chimenc nucleotides, hybnds, duplexes, heteroduplexes, and any nbonucleotide, deoxynbonucleotide or chimenc counterpart thereof and/or corresponding complementary sequence, promoter or pnmer-anneahng sequence needed to amplify, transcnbe or replicate all or part of the defined sequence segment. Defined sequence segments as defined herein are not random-sequence nucleic acids or randomized sequences compnsing nucleic acids, but they ma} be selected from mixtures of nucleic acids compnsing random or randomized sequences. A nucleotide selected from a library compnsing random-sequence nucleotides may be referred to herein as a defined sequence segment, even though the nucleotide sequence ot the random-sequence nucleotide remains unknown unless and until the nucleotide is selected and charactenzed. The terms "defined sequence segment capable of specifically binding to an identified molecule" and "defined sequence segment capable of specifically binding to a selected molecule," when used in reference to a synthetic heteropolymer or aptamenc device, refer to a defined sequence segment compnsing an aptamer capable of specifically recognizing a selected molecule or structural shape. Defined sequence segments of the instant invention include aptamers capable of specific shape recognition, i.e., specific recognition of a structural shape or surface feature. A synthetic defined sequence segment capable of specifically binding a selected molecule is a nonnaturally occurnng defined sequence segment compnsing either a synthetic aptamer, in the case of a synthetic heteropolymer or aptamenc device, or a conjugated specific binding partner, in the case of a nonaptamenc multimolecular device. The terms "designer drug" and "designer drug deli ery" refer to multimolecular structures and MOLECULAR MACHINES compnsing designer receptors. The term "designer receptor," alternatively called a "selected receptor" or "synthetic receptor," refers to a naturally occurnng, recombinant, biological, biologically produced or synthetic nucleotide or nonnucleotide molecule or group of molecules compnsing a specific recognition partner selected from the group consisting of specific binding partners, hybndizable nucleic acid sequences, shape recogmtion partners, specificalh attractive surfaces and specific recognition pairs. Designer receptors are preferably capable of specifically recogmzing a drug or therapeutic receptor and adv antageously include mimetic specific recognition partners (i.e., a receptor mimetics) that mimic or approximate the recogmtion specificity of a selected target (e.g., a therapeutic receptor) for its recogmtion partner (e.g., a drug, hormone or transmitter). Designer receptors may further compnse or attach to catalytic recognition partners selected from the group consisting of enzymes, catalysts, biological recognition sites, biomimetics, enzyme mimetics and selected molecules and selected nucleic acid sequences capable of participating in catalytic recogmtion reactions. Designer receptors are not limited to receptors compnsing selected molecules, which receptors are defined herein to be nonoligonucleotide molecules. Rather, designer receptors include not only nonoligonucleotide molecules (e.g., ligands and receptors), but also nucleotides (e.g., nucleotide ligands and nucleotide receptors) and oligonucleotides (e.g., aptamers and defined sequence segments capable of specifically binding or hybndizing selected nucleic acid sequences). The term "devιce(s)" means a device or system that optionally or advantageoush compnses paired devices. "Different molecular recognition pairs" means o molecular recogmtion or specific recogmtion pairs whose four members compnse at least three different chemical identities. When used in reference to MOLECULAR MACHINES or multivalent molecular structures capable of specificalh recognizing a surface feature, "different molecular recognition pairs" means "different specific recognition pairs," i.e., two specific recognition pairs whose four members compnse at least three different chemical identities, wherein the members ma} be capable ot specific shape recogmtion. "Different specific binding pairs" means two specific binding pairs whose four members compnse at least three different chemical identities. Exemplary pairs of different specific binding pairs include, but are not limited to, two antigen/antibod} pairs with different specificities (e.g., peroxidase/anti -peroxidase and fluorescein/anti-fluorescein); two hgand/receptor pairs with different specificities (e.g., D-mannose/concanavahn A and biotin/avidin); a hgand/receptor pair (e.g., biotin/avidin) and an antigen/antibody pair (e.g., digoxigemn/anti-digoxigenin); two different molecular effector conjugate/hgand pairs (e.g., avidin-peroxidase/biotin and avidin-glucose oxidase/biotin); and a nucleotide ligand-receptor pair and a nucleotide receptor-hgand pair, wherein the nucleotide ligand and nucleotide receptor are different modified nucleotides selected, e.g., b} combinatonal methods, to specificalh bind a selected target molecule or t o different selected target molecules. Even biotin/streptav ldin and biotin avidin are different specific binding pairs as defined herein, because the two specific binding pairs compnse three distinguishable chemical identities (i.e., biotin, streptavidin and avidin). The difference in chemical identity between, e.g., streptavidin v s. avidin or av ldin-peroxidase vs. avidin-glucose oxidase is not accompanied by a sufficient difference in biotin-binding specificity to enable positional control of specific binding pairs. In other words, a defined sequence segment which is biotinylated at each of two defined nucleotide positions does not provide the requisite chemical specificity to attach avidin and streptavidin, on the one hand, or two different av ldin-effector conjugates, on the other hand, in an ordered and reproducible positional relationship to one another. Nucleotide-based templates and multimolecular devices disclosed herein, however, are capable of positiomng different specific binding pairs having similar and even indistinguishable binding specificities. When used in reference to MOLECULAR MACHINES or multivalent molecular structures capable of specifically recogmzing a surface feature, "different specific binding pairs" means "different specific recogmtion pairs," i.e., two specific recognition pairs whose four members compnse at least three different chemical identities, w herein the members may be capable of specific shape recogmtion. "Different specific recognition pairs" means two specific recognition pairs whose four members compnse at least three different chemical identities. The term "discoverable," when used in reference to molecules, matter, data, information, energy , methods, pnnciples, processes, compositions or applications, means know able and heretofore undiscovered, i.e., capable ot becoming discovered and known. The term "discrete aptamenc structure" means a discrete structure compnsing at least one synthetic aptamer and includes aptamer conjugates, aptamer-target complexes. oligonucleotides compnsing one or more copies oi an aptamer sequence, aptamenc devices and discrete heteropolymenc structures, optionally including promoter and pnmer-annealing sequences, e.g., for replication or amplification of a defined sequence segment compnsing the discrete aptamenc structure. The term "discrete heteropolymenc structure" means a discrete structure compnsing at least one synthetic heteropolymer and optionally including one or more attached nucleotide or nonnucleotide molecules, including, w ithout limitation, spacer molecules, nucleotide spacers, linker oligonucleotides. nonnucleotide linkers, selected molecules and selected nucleic acid sequences. A discrete heteropolymenc structure compnses at least a first defined sequence segment compnsing an aptamer and a second defined sequence segment which is capable of specific recogmtion or compnses a conjugated selected molecule. The second defined sequence segment compnses either an aptamer, a single-stranded, double-stranded, partially smgle-stranded or partially double-stranded nucleotide sequence capable of hybridizing or specifically binding to a selected nucleic acid sequence, or a defined sequence segment capable oi positiomng a conjugated molecule within suitable proximity to provide single-molecule detection or functional coupling between the conjugated molecule and an aptamer target specificalh bound to the first defined sequence segment. Discrete heteropolymenc structures of the invention include s}nthetιc heteropohmers, multivalent heteropolymenc hybnd structures and multimolecular heteropolymenc complexes. All discrete heteropolymenc structures are also discrete aptamenc structures, but the converse is not true, i.e., not all discrete aptamenc structures are discrete heteropolymenc structures. The term "discrete structure" refers to any single molecule or to any group of molecules comprising nucleotides, wherein the molecules are bound to one another either covalenth or through noncovalent interactions or, in the case of a multimolecular device, are required to specifically bind or dissociate dunng device function. Discrete structures of the present invention, also refened to herein as "discrete nucleotide structures" and "nucleotide- based discrete structures," include defined sequence segments, aptamers, aptamer-target complexes, nucleotide-based multimolecular devices, discrete aptamenc structures, discrete heteropolymenc structures, synthetic heteropolvmers, and multivalent heteropolymenc 99/60169 - 31 - hybnd structures compnsing two or more hybπdized s}nthetic heteropohmers, and multimolecular heteropolymenc complexes compnsing one or more nonoligonucleotide molecules specifically bound to one or more synthetic heteropohmers or multivalent heteropolymenc hybnd structures. A discrete structure compnsing one synthetic defined sequence segment capable of specifically recogmzing a nonoligonucleotide molecule and another defined sequence segment capable of specifically recognizing a nucleotide or nonnucleotide molecule is or compnses a synthetic heteropolymer, unless both defined sequence segments specifically recognize the same molecule or one unconjugated defined sequence segment hybndizes to an unconjugated pnmer used for amplification. The term "disease target" means a therapeutic target or pathophysiological target and includes therapeutic receptors and pathophysiological receptors. The term "divergent and self-sustaining," when used in reference to cycles of expressing and transposing impnnts and progeny of a selected target molecule or a selected population of selected target molecules using a polydiverse nucleotide library, refers to an iterativ e, parallel, simultaneous or sequential positive feedback process capable of generating an increasingly diverse assortment of molecular structures, shapes and activities without heretofore known limits on achievable diversity. The term "docking surface," when used in reference to a member of a recognition pair, means the operative points of contact, atoms, fields of electrostatic attraction or Connolly surface(s) that interact with corresponding points, atoms, fields or surface(s) of a recognition partner. The terms "donor" and "acceptor," when used in reference to functionally coupled libraries, are introduced herein as useful metaphors in respect of conesponding terms used to descnbe functionally coupled effector molecules. A donor library is capable oi donating (i.e., providing or compnsing) a member, property, activity or specificity that can be recognized or impnnted by a member compnsing an acceptor library . The term "drug" as used herein means a molecule, group of molecules, complex or substance admimstered to an organism for diagnostic, therapeutic, medical or veteπnary purposes. Drugs include externally and internally administered topical, localized and systemic human and animal pharmaceuticals, treatments, remedies, nutraceuticals, cosmeceuticals, biologicals, devices, diagnostics and contraceptives, including preparations useful in clinical and veteπnary screening, prevention, prophylaxis, healing, wellness, detection, imaging, diagnosis, therapy, surgery, mo toπng, cosmetics, prosthetics and forensics. The term "drug" may optionally be used in reference to agnceutical, workplace, military, industnal and environmental therapeutics or remedies compnsing selected molecules or selected nucleic acid sequences capable of recognizing cellular receptors, membrane receptors, hormone receptors, therapeutic receptors, microbes, viruses or selected targets compns g or capable of contacting plants, animals and/or humans. "Effector molecules," also refened to as "effector species," "effectors" and "molecular effectors," are selected nonoligonucleotide molecules or groups, complexes or conjugates of selected nonoligonucleotide molecules capable of transforming energy into work, work into energy , work or energy into information, or information into work or energy and include, but are not limited to, signal-generating species, stimulus-response molecules, response-generating molecules, enzymes, synthetic enzymes, drugs, catalytic antibodies, catalysts, contractile proteins, transport proteins, regulatory proteins, redox proteins, redox enzymes, redox mediators, cytochromes, electroactive compounds, photoactive compounds, supermolecules, supramolecular devices and shape-memory structures. "Electronic coupling" as used herein means functional coupling relying on the transfer ot electrons and includes, for example and without limitation, single-electron transfer and coupling mediated by direct, through-space overlap of relevant donor and acceptor orbitals and by through-bond superexchange(s). Electromc coupling may occur by single-step or multistep processes within a molecule or between molecules positioned by noncovalent or covalent ιnteractιon(s), advantageously direct covalent bonding. "Enhancing or modulating detectabihty" means, without limitation, controlling or influencing the size, shape, charge, structural properties, position, chemical composition, chemical identity, energy state, binding, activity or functional properties of a molecule; controlling or influencing the amount, mass, concentration, copy number or spatial location of a molecule, product, transcnpt, replicate, complex, particle or structure; or controlling or influencing the relative positions of at least two molecules or the functional coupling between them. The terms "evolv ing" and "evolution," when used in reference to the information compnsing or w illfully accessible through paired or functionally coupled informational devices, mean learning. No effort is made to reconcile the instant use oi the term "learning" with art-accepted definitions regarding machine learning, artificial intelligence or expert sy stems. "Functional coupling" and "functionally coupled" mean that at least two processes are connected by a common reaction, event or intermediate or that at least two compositions, which may be molecules, species, substances, structures, devices, groups or combinations thereof, participate as donor and acceptor in the transfer of mass (e.g., molecules, atoms or subatomic particles) or energy (e.g., photons, electrons, kinetic or potential energy, entropy, enthalpy, work or heat), or that two processes or compositions act on a third process, composition, disease or condition in an additive, partially additive or subtractive, mutuahstic, synergistic, cooperative, combined or interdependent manner. Examples of functional coupling are well known in the art (e.g., Gust et al. ( 1993) Accounts of Chemical Research 26: 198-205: Sheeler et al. (1983) Cell Biology: Structure, Biochemistry, and Function, p. 203, John Wiley & Sons, Inc., New York; Saier (1987) Enzymes in Metabolic Pathways : A comparative Study of Mechanism, Structure, Evolution, and Control, pp. 48- 59 and 132-136, Harper & Row Publishers, New York; Aidley (1989) The Physiology of Excitable Cells, Third Edition, p. 320, Cambπdge University Press, Cambndge; Bray et al. (1957), Kinetics and Thermodynamics in Biochemistry, p. 135, Academic Press, New York; and Guyton (1971) Textbook of Medical Physiology, Fourth Edition, p. 786, W.B. Saunders Company, Philadelphia). Functional coupling includes cooperativity between or among two or more molecules. The terms "functional coupling" and "functionally coupled," when used in reference to the interaction between two recognition pairs, mean that the binding or activity ot a member of a first recognition pair influences the binding or activity of a member of a second recognition pair or that members of both recogmtion pairs bind to or act upon a common substance, disease, condition or process in an additive, partially additive, combined or cooperativ e manner. Members of both recognition pairs bind to or act upon a common disease or condition, tor example, when two (or more) functionally coupled drugs and/or targeting elements bind or act in a combined, additive or synergistic manner at a single disease target or at two or more neighboπng sites, receptors or targets. "Functional coupling," hen used in reference to single-molecule detection of an aptamer, means to enable detection of an individual aptamer-target complex or multimolecular structure comprising a pair or group of molecules attached by nucleotides or, alternatively, to enable discπmination of an individual molecular complex or multimolecular structure from an uncomplexed nucleotide or nonnucleotide molecule or plurality of molecules. The term "functionally coupled," when used in reference to paired hbranes or a library pair, means that at least one molecule (i.e., product) selected from a first (i.e., donor) library (hereinafter a product ot a donor library) is used as a selected target (i.e., precursor or substrate) tor screening and or selection of a second (i.e., acceptor) library . The term "functional element," when used to descnbe a nucleotide, segment, template or selected molecule compnsing a multimolecular structure or MOLECULAR MACHINE, refers to a nucleotide or nonnucleotide molecule, residue, site, sequence or group having a selected activity, property, specificity, structure or function. Functional elements include, without limitation, selected molecules, nucleotides, modified nucleotides, selected nucleic acid sequences, defined sequence segments, recognition sites and replicates, clones, mimetics, recognition elements, partners and impnnts thereof and progeny therefrom. The term "grafting," when used in reference to attachment of a segment, template, multimolecular structure or MOLECULAR MACHINE to a surface, means specific attachment in such manner that at least one recogmtion domain or functional element is displayed on the surface in an oπented or polaπzed manner that enables a useful function or desirable result, e.g., specific adsorption or extraction, solid phase separations, surface catalysis, specific recognition or catalytic recognition assays or processes, or scanning, imaging and or mapping of a displayed recogmtion domain or functional element using an analytical tool, e.g., scanning probe microscopy, laser scanning or a hyphenated method. The terms "group of and "plurality of," when used in reference to molecules, elements, recognition partners, hbranes, sequences, receptors, drugs, recognition pairs and multimolecular structures, means at least two. A member compnsing a group or plurality of members may be either attached to another member or unattached. The terms "heteropolymer-based" and "heteropolymenc" mean compnsing at least one synthetic heteropolymer. The term "heteropolymenc discrete structure" means a discrete structure compnsing at least one synthetic heteropolymer, i.e., at least a first defined sequence segment compnsing an aptamer and a second defined sequence segment which is a conjugated defined sequence segment or is capable oi specific recognition, including impnnts, progeny, replicates and mimetics of nucleotides compnsing synthetic heteropohmers. Heteropolymenc discrete structures include, lor example and without limitation, a synthetic heteropolymer; a multivalent synthetic heteropolymer; a multivalent heteropolymenc hybnd structure; a multimolecular complex; a pair or group of attached synthetic heteropolvmers; a pair or group of attached nucleotides compnsing a synthetic heteropolymer; a pair or group of attached nucleotide and nonnucleotide molecules compnsing a synthetic heteropolymer; a synthetic heteropolymer attached to a nucleotide or nonnucleotide molecule; a synthetic aptamer attached to a defined sequence segment capable of specific recogmtion; a synthetic aptamer attached to a defined sequence segment compnsing a conjugated molecule; a synthetic aptamenc first defined sequence attached via a nucleotide spacer, spacer molecule, oligonucleotide linker or nonnucleotide linker to a second defined sequence segment capable of specific recogmtion; a synthetic aptamenc defined sequence segment attached v ιa a nucleotide spacer, spacer molecule, ohgonucleotide linker or nonnucleotide linker to a conjugated defined sequence segment; a plurality of nucleotide or nonnucleotide molecules joined by at least one synthetic heteropolymer; a synthetic first aptamer and at least a second aptamer conjugated to the first aptamer; a plurality of aptamers capable of specifically recognizing different target molecules, wherein the aptamers are attached to one another either directly or indirectly; and an} of these discrete structures compnsing, attached to or capable of attaching to a molecule, nucleotide, complex, multimolecular structure, solid support or transducer surface. "Hybndizing" refers to specific binding between two selected nucleic acid sequences through complementary base pamng, i.e., hybndization of complementary sequences. Such bonding is also referred to as Watson-Cnck base painng. The binding between complementary nucleic acid sequences is preferabh refened to as "hybπdizing" or "hybndization" rather than "specific binding." Conversely, binding between noncomplementary nucleotide sequences is refened to as "specific binding," "specific recogmtion'' or "molecular recogmtion." Hybπdized, hybndizable, annealed and/or complementary nucleic acid sequences (e.g., strands compnsing or capable of forming hybnds, duplexes or double-stranded regions) are not referred to herein as "specific binding partners" or "members of a specific binding pair," but instead as "hybndized," "hybndizable" or "complementary" nucleotides. For hybndization, a sufficient degree of complementaπty is required such that stable and/or reproducible binding occurs between two selected nucleic acid sequences. However, perfect complementaπty is not required and may not be prefened for embodiments relying on dissociation of a hybπdized nucleic acid sequence, e.g., dissociation of a selected nucleic acid sequence from a defined sequence segment of a multimolecular device concomitant either with hybridization of the defined sequence segment to a more complementary selected nucleic acid sequence or with high- affinity specific binding to a selected molecule or selected nucleic acid sequence. "More complementary" means a second selected nucleic acid sequence having a relatively higher melting temperature, greater number of complementary nucleotides. longer complementary sequence segment, higher percent base painng, higher G-C content or percent, or greater stability in hybndized form than a first selected nucleic acid sequence. The term "immobilized" means insoluble, insolubihzed or compnsing, attached to or operatively associated with an insoluble, partially insoluble, colloidal, particulate, dispersed, suspended and/or dehydrated substance or a molecule or solid phase compnsing or attached to a solid support. When used in reference to a multimolecular drug delivery system of the instant invention (e.g., a multimolecular structure compnsing a designer drug, smaRTdrug, tethered recognition device, prodrug complex or multimolecular dev ice) the term "immobilized" refers either to a multimolecular structure that is itself insoluble or to a multimolecular structure that is rendered insoluble by attachment to a biological or biocompatible solid support. For example, a drug delivery composition may be immobilized to a biocompatible solid support before administration, or it may be immobilized to a biological solid support dunng or after administration. The term "immobilized multimolecular structure" means a MOLECULAR MACHINE of the invention which compnses or attaches to a solid support. In the case of multimolecular structures compnsing a molecular adsorbent, multimolecular adherent or multimolecular adhesive, the solid support preferabh compnses an amphibious or specifically attractiv e surface, optionally a chemically bland surface. The terms "impnnt" and "impnnted," when used in reference to the process or product of impnnting a selected target, pπnt molecule or multimolecular structure, refer to an antndiotypic or anti-antndiotypic (i.e., idiotypic) recognition partner and any recognition partner thereof compnsing a conesponding antiidiotvpic or idiotypic specificity, i.e., a recogmtion partner that is capable of mimicking or recognizing the selected target, pnnt molecule or multimolecular structure. "Impnnting" means any process for producing an impnnt or recognition partner of a molecule or multimolecular structure or an impnnt or recogmtion partner thereof, including, without limitation, polymenc casting and molding, library selection of target-specific recogmtion elements, and transposition of a selected target through paired hbranes, preferably paired hbranes compnsing a nucleotide library. The impnnt or recogmtion partner may be a first, second or subsequent generation impnnt or impnnted impnnt, ldiotype or antiidiotype, mimetic or antimimetic of a target recogmtion element, all of which generations are refened to herein as impnnts. An impnnt may faithfully reflect, recognize, mimic, replicate or approximate the recognition properties (e.g., specificity , affinity, kinetics) of a parent recogmtion element. Alternatively, an impnnt may be a weak, strong or moderate competitor, crossreactant, structural or functional analog, partial or mixed agomst or antagonist compared with its parent recogmtion element or a mimetic, recogmtion partner, replicate or mutation thereot or progeny theretrom, e.g., a product ot molecular impnnting, combinatonal selection, amplification or transposition through a nucleotide libran . The term "impnnt library" means a mixture of molecules designed, selected, collected, ev olved or modified to compnse an idiotypic or antiidiotvpic impnnt molecule (i.e., a mimetic or antimimetic molecule) capable ot mimicking, approximating, crossreacting with, competing with or recogmzing a selected target compnsing a selected molecule, selected nucleic acid sequence or surface feature. "Independent operabihty," when used in reference to a defined sequence segment compnsing a synthetic heteropolymer, means that the defined sequence segment compnsing the synthetic heteropolymer retains the binding specificity for which it was selected or designed, i.e., the desired specificity of the defined sequence segment is not lost with incorporation into the synthetic heteropolymer. In other words, the defined sequence segment remains operable independent of its incorporation within the synthetic heteropoh mer. The term "information" means the knowledge compnsing a set ot data and all interactions among the data, including, e.g., implications and actionable results compnsing interactions among the data. "Known intormation" means information that is willfully accessible. Unknown intormation may be either knowable (i.e., discov erable) or unknowable (i.e., undiscoverable). The term "informational device" refers to a synthetic dev ice, composition, product, medium, machine, program, code, process, library, database or means for marking, displaying, representing, mapping, transposing, impnnting, embodying, stonng, copying, imaging, simulating, modeling, replicating, archiving, companng, analyzing, contrasting, searching, researching, conveying or transmitting data, information or instructions, particularly including molecular modeling, biocomputing, multifactonal search engines and hardware and software designed for ultrafast, high-capacity, high-performance approaches to intenogating, analyzing, companng, contrasting, integrating, interpreting, mapping, transposing, modeling and simulating molecular structure, function and dynamics, including chemical composition, polymer sequence, secondary, tertiary and quaternary structure, three-dimensional shape, docking surfaces, intermolecular d}namιcs, activity, catalysis and quantitative structure-activity relationships (QSAR). The term "information space" means the set of all sets of information, including known intormation and unknown information. The term "informational system" means a pair of functionalh coupled informational devices, i.e., paired informational devices. The term "instructions" refers to wntten or nonwntten letters, words, numbers or numerals, recordings, transmissions, replicas, representations, tacsimiles, pictures, signs, symbols, digital or analog data or code, static or dynamic images, audio, isual, tactile, olfacton or other senson , perceptible, detectable or inteφretable messages, data or information Detection, deciphenng, decoding, deconvolution or inteφretation of instructions ma} be accomplished by sensory means or may require suitable instrumentation, e.g., a light source, laser, scanner, reader, transmitter, detector, sensor, transducer, transformer, amplifier, actuator, magnifier, decoder, microphone, recorder, imaging system The term "intelligent," when used in reference to an informational devιce(s) or system(s), means capable of learning. When used in reference to learning for willful purpose(s), intelligence requires either a functionally coupled system compnsing an informational device and a human (and/or humanly introduced information source) or a functionalh coupled paired informational device compnsing, attaching to, or capable of attaching to an external information source. The term "knowable," when used in reference to molecules, matter, data, information, energy, methods, pnnciples, processes, compositions or applications, means capable of being kno n or discovered, i.e., not unknowable. The terms "knowable alternatives" and "knowable." when used to descnbe a prefened embodiment, composition, method or use of the instant invention, mean the inventor is aware that present and future alternatives and discovenes will extend and improve the descnbed embodiment, composition, method or use, such alternatives being predictable and hkeh deπv atives or progeny of the instant invention. The terms "knowledge" and "known information" refer to information that is known, i.e.. willfully accessible. "Knowledge" and "known information" are synonymous The term "learning," when used in reference to an informational devιce(s) or system(s), means that the domain of informational space comprehended by the devιce(s) or system(s) (i.e., device or system information) evolves in parallel with the evolving information domain encompassed by the term "heretofore known" (i.e., knowledge). The term "library" refers to a random or nonrandom mixture, collection or assortment of molecules, matenals, surfaces, structural shapes, surface features or, optionalh and without limitation, monomers, polymers, structures, functions, precursors, products, modifications, deπvatives, substances, conformations, arrangements, shapes, features, activities, properties, energies, conditions, treatments, parameters, methods, processes, data or information. The term "(hbranes)^" refers to nucleoplastic hbranes and members of the set of all possible nucleoplastic hbranes compnsing nucleotide, nonnucleotide and paired hbranes The terms "library pair" and "paired hbranes" refer to at least two hbranes capable of being functionally coupled, i.e., linked by a recogmtion pair, member or library compnsing a target or probe, precursor or product, donor or acceptor hich connects the hbranes in diversity space. A paired nucleotide-nonnucleotide library is a paired library compnsing a nucleotide library functionally coupled to a nonnucleotide library The terms "library-selected" and "library selection." hen used in reference to a molecule, probe, product or impnnt, refer to a heretofore unknown or unidentified nucleotide or nonnucleotide molecule (i.e , a selectable molecule) w hich becomes identified by screening and/or selection of a library Librar -selected molecules include, e g., selected molecules, defined sequence segments, selected nucleic acid sequences, shape-specific probes, modified nucleotides, nucleotide ligands and nucleotide receptors identified by library screemng and/or selection, preferably screening and selection of nucleic acid hbranes, modified nucleotide hbranes and nucleotide-encoded chemical hbranes. Heretofore known selected molecules, by contrast, are themselves used as targets for screening and selection of nucleotides comprising aptamers, nucleotide ligands, nucleotide receptors, nucleotide catalysts, catalytic nucleotides and strucmral shape recogmtion probes. Once a librar -selected molecule is identified and therefore becomes known, it may, in turn, be used as a selected target molecule for screemng and selection of a nucleic acid library or nucleotide-encoded chemical library to identify heretofore unknown aptamers, nucleotide ligands, nucleotide receptors, nucleotide catalysts, catalytic nucleotides and structural shape- lecogmtion probes The term "librar -selected nucleic acid sequence" refers to a selected sequence, three-dimensional structure or activity compnsing a nucleic acid, nucleotide and/or nucleotide-encoded nonnucleotide molecule selected from a mixture compnsing synthetic and/or biologically deπved nucleotides, conjugated nucleotides and/or immobilized nucleotides Library-selected nucleic acid sequences include, without limitation, any heretofore unknown nucleic acid sequence, structure, activ ιty , nucleotide analog, modified nucleotide or nonnucleotide molecule, particularly including aptamers, nbozymes, catalytic nucleotides, nucleotide ligands, nucleotide receptors, nucleotide catalysts, structural shape probes and sequences or structures compnsing at least two recogmtion elements. Also included is any nucleic acid sequence compnsing or attaching to a nucleotide or nonnucleotide molecule that is capable of functional coupling with another nucleotide or nonnucleotide molecule compnsing a library. Importantly, screening and selection of a nucleotide hbrary for a nucleotide, nucleotide replicate, impnnt, clone, denvative, mimetic or conjugate may be achieved by single-molecule detection methods disclosed herein. Also, selected molecules identified by screening and selection oi a nonnucleotide library by single- molecule detection may be advantageously transposed into nucleotide space, enabling amplification, sequencing, digital encoding, charactenzation and archiving of nucleotide impnnts of nonnucleotide molecules and hbranes. The importance of this capability will be apparent to the skilled artisan on reading this disclosure. The term "ligand" means a selected nonoligonucleotide molecule capable of specifically binding to a receptor by affinity-based attraction that does not involve complementary base painng. Ligands include, but are not limited to, receptor agonists, partial agonists, mixed agonists, antagonists, response-inducing or stimulus molecules, drugs, hormones, pheromones, transmitters, autacoids, growth factors, cytokines, prosthetic groups, coenzymes. cofactors, substrates, precursors, vitamins, toxins, regulatory factors, antigens, haptens, carbohydrates, molecular mimics, pnnt molecules, structural molecules, effector molecules, selectable molecules, biotin, digoxigenin, and congeners, crossreactants, analogs, competitors or deπvatives of these molecules as well as library-selected nonoligonucleotide molecules capable of specifically binding to selected targets and conjugates formed by attaching any of these molecules to a second molecule. The terms "linker" and "linker molecule" refer to molecules or groups which are capable of joining two molecules and include, as the case may be, linker oligonucleotides, nucleotide spacers, spacer molecules, linker molecules and nonnucleotide linkers. The terms "linker molecule," "linker" and "nonnucleotide linker," when used in reference to nonnucleotide molecules that link nucleotides, mean molecules and groups of molecules capable of joining at least two nucleotides either cov alently or noncov alently. Nonnucleotide linkers include, for instance and without limitation, spacer molecules, selected molecules capable of attaching two aptamers (i.e., joining the two aptamers to form an aptamenc multimolecular complex or synthetic heteropolymer), nonnucleotide dendnmers. dendrons, peptides, proteins, nonnucleotide linkages and bπdges, nonnucleotide monomers, dimers and polymers, ligands (e.g., biotin, digoxigenin, FITC, DNP and peroxidase) and receptors (e.g., avidin, streptavidin and anti-digoxigemn, anti- FITC, anti-DNP and anti-peroxidase antibodies), hpids, sugars, polyethylene glycols, cholesterol, fusion proteins, bispecific antibodies, chelating agents, intercalating agents, crosshnking agents, and nonnucleotide molecules compnsmg bifunctional, heterofunctional and multifunctional molecules and ohgonucleotide linkers. The term "linker ohgonucleotide," also referred to herein as an "ohgonucleotide linker," refers to an ohgonucleotide sequence, plurality of ohgonucleotide sequences, monomers or polymers, or a linker molecule capable of specifically binding or hybπdizing to two or more conjugated defined sequence segments or to second defined sequence segments of two or more synthetic heteropolvmers, thus joining the conjugated defined sequence segments or synthetic heteropohmers into a discrete structure. An o gonucleotide linker may also join two or more nucleotides covalently or a first nucleotide covalently and a second nucleotide noncovalently. Oligonucleotide linkers conjugated to selected molecules may also join pairs or groups of nucleotides by specific binding or by a combination of specific binding, hybridization and covalent attachment. Alternatively, linker oligonucleotides may first noncovalently attach two or more nucleotides (e.g., by specific binding or hybridization) followed by covalent attachment. Examples of the linker oligonucleotide include, but are not limited to: an oligonucleotide; a stem-loop, bulged or pseudoknot structure having single-stranded ends capable of hybridizing to the second defined sequence segments; a duplex, triplex or quadruplex structure having single-stranded ends capable of hybridizing to the second defined sequence segments; a branched-chain or branched-comb structure having defined sequence segments capable of hybridizing to the second defined sequence segments; a nucleic acid dendron or dendrimer (e.g., Tomalia et al. ( 1993) In: Topics in Current Chemistry, pp. 193-245 Springer, Berlin) or a dendron, dendnmer or other branched or hyperbranched structure attached to nucleotides comprising defined sequence segments capable of hybridizing to the second defined sequence segments; a nonoligonucleotide dimer, multimer or polymer comprising monomeric subunits attached to defined sequence segments of nucleotides capable of hybridizing to the second defined sequence segments; a heteroconjugate comprising a nonoligonucleotide molecule or group of molecules attached to defined sequence segments of nucleotides capable of hybridizing to the second defined sequence segments; a single-stranded or partially single-stranded nucleic acid molecule or group of molecules having a defined topology comprising defined sequence segments capable of specifically binding or hybridizing to the second defined sequence segments; a double-stranded or partially double-stranded nucleic acid molecule or group of molecules having a defined topology comprising defined sequence segments capable of specifically binding or hybndizing to the second defined sequence segments; and a cyclic oligonucleotide or circular structure having defined sequences capable of hybndizing to the second defined sequence segments. Oligonucleotide linkers advantageously comprise replicatable nucleotides. The terms "machine," "machine learning," "machine-directed" and "machine- intelligence," when used in reference to an informational device or system, refer to products and processes compnsing or enabled, facilitated or accelerated by informational devices of the invention, preferably paired informational devices comprising informational systems, more preferably informational systems comprising or capable of attaching to an evolving information source or expert system. The term "mapping library" means a library comprising a plurality' of selected recognition partners identified, collected or accumulated by screening and/or selection of imprint libraries, preferably a diverse plurality of imprint libraries, to map, imprint, transpose, evaluate or characterize the recognition properties of a plurality of target molecules, preferably a selected population of selected molecules. In other words, a preferably diverse plurality of selected nucleotides comprising a mapping library is used to transpose (i.e., impnnt) the recognition properties of a selected population of selected molecules into a selected population of selected nucleotides (i.e., a "receptive audience") compnsing the mapping library. The mapping library is optionally selected and evolved over time by accumulating selected impnnt library members capable of recogmzing at least one target molecule compnsing a selected population of selected molecules, e.g., the set of immunoglobulin light chains or CD antigens compnsing a fractionated pool of umbilical cord blood. Selection and accumulation of the selected population of selected nucleotide recognition partners compnsing a mapping library from a plurality of impnnt hbranes may be viewed as a process of rejecting impnnt library members that do not recognize at least one member compnsing a selected population of selected molecules, advantageously subjecting selected members to iterative cycles of rejection under conditions of vanable and increasing stnngency and/or selection pressure. Mapping hbranes include the set of nonrejected members following iterative screening and selection of impnntable nucleotide hbranes for specific binding and shape-specific recogmtion elements, optionally including selected specific recognition elements from nucleotide-encoded chemical hbranes, e.g., nucleotide ligands and nucleotide receptors. The terms "matenals," "selected matenals" and "identified matenals," when used in reference to attractive surfaces and the selection oi matenals having heretofore unknown recognition properties, refers to chemically bland substances, amphibious surfaces and compositions compnsing selectable structural shapes and surface features made up of molecules, as distinct from the chemical identities or recognition properties of the constituent selected molecules themselves. The term "recogmtion property," when used to descnbe a selected mateπal, refers to the specific attractivity of a structural shape or surface feature and does not include the heretofore known recogmtion properties of the selected molecules compnsing the matenal. Matenals, structures, structural shapes, surfaces and surface features ot the instant invention can be selected for the ability to recognize and specifically attach selected molecules and nucleotides. Conversely, selected molecules and nucleotides of the invention are capable ot recognizing and specifically attaching to selected matenals, structures, structural shapes, surfaces and surface features. A selected molecule with heretofore known recogmtion properties which attaches or makes up a matenal or surface is preferably refened to herein as, e.g., an immobilized molecule or a solid support, solid phase or solid phase reagent. The term "mixture" means a composition compnsing a plurality of molecules or at least two different substances that are not chemically bound to each other. The terms "modified nucleotide" and "denvatized nucleotide" mean synthetic bases, i.e., nonnaturally occurnng nucleotides and nucleosides, particularly modified or denvatized adenine, guanine, cytosine, thymidine, uracil and minor bases. Although there is substantial overlap between the terms "modified" and "deπvatized," modification tends to relate broadly to any difference or alteration compared to a conesponding natural base, whereas deπv atization refers more specifically to the addition or presence of different chemical groups, i.e., modification by the addition of chemical groups, functional groups and/or molecules. Although there is also overlap between the terms "modified nucleotide" and "nucleotide analog" as used herein, "modified nucleotide" typically refers to congeners of adenine, guanine, cytosine, thymidine, uracil and minor bases, whereas "nucleotide analog" further refers to synthetic bases that may not compnse adenine, guamne, cytosine, thymidine, uracil or minor bases, i.e., novel bases. The terms "molecular adsorbent" and "mimetic adsorbent" refer to an amphibious, chemically bland, specifically attractive, modified or impnnted solid phase, matenal, surface or structure compnsing or specifically attaching a multimolecular strucmre or multimolecular dev ice, preferably a multimolecular structure compnsing a multiv alent template, or hav ing a recogmtion property introduced by grafting, templating, copying, impnnting or transposing a segment, conjugated segment, multivalent template or multimolecular structure, or hav ing a recogmtion property identified by screening and/or selection ot a surface library tor a specifically attractive surface feature. The term "molecular attractor" means a plastic segment or plastic template used to generate and test hypotheses regarding the prospective participation of selected template recogmtion sites and template-ordered recogmtion partners in cooperative molecular interactions. Advantageously, the molecular attractor and a functionally coupled informational system are used in a consorting station to explore and map proximity space and functional coupling space for different combinations of selected molecules and positioning templates. The term "molecular binding specificity," when used in reference to specific binding, means molecular recognition between specific binding partners and does not include specific surface attractivity or structural shape recognition. The term "molecular complex," when used in reference to a pair or group of molecules, means at least two molecules attached to one another either reversibly, quasireversibly or pseudoirreversibly. The terms "molecular delivery" and "molecular delivery system" refer to a multimolecular structure capable of specifically recogmzing, binding or stonng, and transporting, carrying, providing, presenting, dehvenng and/or releasing a nucleotide or nonnucleotide molecule to a selected target, receptor, site, region, proximity or destination. A molecular delivery system compnses at least two different recognition sites or pairs capable of functioning in an additive or cooperative manner, e.g., to deliver a selected molecule or selected nucleic acid sequence to a selected target and/or to modulate the structure or activity of the selected target. The term "molecular diversity" refers to the realm of molecular structure-activity space and includes any set or subset of known and/or knowable molecules compnsing the diversity space encompassed by the set of all molecules, known and unknown, excluding specifically attractive surfaces (i.e., structural shapes and surface features). The term "art- accepted molecular diversity" means structure-activity space. The terms "MOLECULAR MACHINE" and "MOLECULAR MACHINES" refer to claimed methods and devices of the instant invention, including, without limitation, nucleotide-based and nonnucleotide aptamenc multimolecular devices, heteropolymenc discrete structures, multimolecular delivery systems, promolecular dehvery devices, multivalent molecular structures, molecular adsorbents, multimolecular adherents, multimolecular adhesives, molecular lubncants, multivalent heteropolymenc hybnd structures, synthetic heteropolvmers, tethered specific recogmtion devices, paired specific recognition devices, nonaptamenc multimolecular devices, multivalent impnnts, multimolecular drug dehv ery systems, designer drugs, smaRTdrugs, shape-specific probes, paired nucleotide-nonnucleotide mapping hbranes, recogmtion elements compnsing synthetic nucleotides selected by single-molecule detection, library-selected impnnts ot synthetic nucleotides selected by single-molecule detection, immobilized multimolecular structures, surface hbranes, specifically attractive surface features, multimolecular switches, multimolecular sensors, multimolecular transducers, paired templates, paired recognition pairs, paired MOLECULAR MACHINES and nucleotide-based or nonnucleotide precursors, products, progeny, combinations, clones, replicates, impnnts, mimetics and conjugates thereof and progeny therefrom, including any of these MOLECULAR MACHINES operatively attached or functionally coupled to a molecule, nucleotide, molecular scaffold, multimolecular structure, solid support, transducer surface and/or informational device The terms "MOLECULAR MACHINE pair" and "paired MOLECULAR MACHINES" refer to pairs compnsing at least two MOLECULAR MACHINES, optionally pairs of pairs or networks ot pairs or paired pairs, compnsing at least two MOLECULAR MACHINES, wherein the two members of a MOLECULAR MACHINE pair function collectively or cooperatively to achieve a desired result Advantageously, the two members compnsing a MOLECULAR MACHINE pair are functionally coupled. Two members of a functionally coupled MOLECULAR MACHINE pair may be attached to each another directly or indirectly, or they may be functionally coupled by means of a mobile substance, e.g., a pheromone, chemical transmitter, mediator or shuttle species. The term "molecular matnx," when used in reference to impnnting or transposing a property, specificity, shape, structure or function from a molecule into a matnx, refers to a specifically attractive surface, structure, substrate or matenal, e.g., a chemically bland surface compnsing a specifically recogmzable surface feature. It will be appreciated by the skilled artisan on reading this disclosure that the distinction between chemically bland surfaces and chemically diverse molecules will become blurred as chemically bland surfaces are endowed with recogmtion properties as descnbed herein, e.g., by surface library selection, grafting, impnnting and transposition. The term "molecular medium," when used in reference to impnnting or transposing a property, specificity, shape, structure or function from one molecule into another, means a nucleotide or nonnucleotide molecule compnsing an impnnt or impnnt library. "Molecular mimics" and "mimetics" are natural or synthetic nucleotide or nonnucleotide molecules or groups of molecules designed, selected, manufactured, modified or engineered to have a structure or function equivalent or similar to the structure or function of another molecule or group of molecules, e.g., a naturally occurnng, biological or selectable molecule. Molecular mimics include molecules and multimolecular structures capable of functioning as replacements, alternatives, upgrades, improvements, structural analogs or functional analogs to natural, synthetic, selectable or biological molecules. The term "molecular recognition," when used in reference to heretofore known binding reactions, pairs, partners and complexes, means specific binding or hybndization and includes 1 ) specific binding between a ligand and receptor, 2) specific binding between a defined sequence segment and a nonoligonucleotide molecule, 3) specific binding between defined sequence segments and/or selected nucleic acid sequences, and 4) hybndization between complementary nucleic acid sequences and/or defined sequence segments. The terms "molecular recogmtion" and "specific recogmtion" may be used interchangeably in certain instances. For example, when used in reference to recognition of a specifically attractive surface feature, "molecular recognition" means and includes specific recogmtion, i.e., structural shape recognition as well as specific binding and hybndization. However, shape-specific recogmtion of a strucmral shape or surface feature by a shape-specific probe of the instant invention is preferably refened to as specific recognition rather than molecular recognition. When used in reference to synthetic defined sequence segments, synthetic aptamers. synthetic heteropolvmers, nucleotide ligands, nucleotide receptors, shape recognition elements, specifically attractive surfaces and MOLECULAR MACHINES disclosed herein, the term "molecular recognition" may include and does not necessanly exclude specific recognition of structural shapes and surface features. The term "molecular recognition pair" means two molecular recognition partners that specifically bind or hybndize to one another. The terms "molecular recogmtion partners" and "members of a molecular recogmtion pair" refer to pairs of molecules capable of specifically binding or hybndizing to one another, i.e., members of a specific binding pair or a pair of hybndizable nucleic acid sequences and include, without limitation, ligands, receptors, aptamers, aptamer targets, hybndizable nucleotides, nucleotide ligands, nucleotide receptors, defined sequence segments, linker oligonucleotides, nonnucleotide linkers, selected nucleic acid sequences, selected molecules and molecular recognition sites compnsing molecular scaffolds and multimolecular structures. MOLECULAR MACHINES and multivalent molecular structures disclosed herein may further be capable of structural shape recogmtion, i.e., specific recognition of a surface feature. The terms "molecular recognition partner" and "specific recognition partner" may in certain cases be used interchangeably. A surface feature recognized by a specific recognition site of a MOLECULAR MACHINE or multivalent molecular structure is preferably refened to as a specific recogmtion partner rather than a molecular recognition partner. The term "molecular recogmtion site" means the operative specific binding site, docking site, receptor site, epitope, defined sequence segment, nucleotide or complementary sequence of a member of a molecular recogmtion pair. In the case of a MOLECULAR MACHINE or multimolecular structure capable of specifically recognizing a structural shape or surface feature, "molecular recogmtion site" means and includes a shape-specific recogmtion element, i.e., a shape-specific probe. A surface feature recognized by a molecular recognition site of a MOLECULAR MACHINE or multivalent molecular structure is preferably refened to as a specific recognition partner or shape recogmtion partner rather than a molecular recognition partner or specific binding partner The term "molecular recogmtion unit" (MRU) is a term of art that refers to a (preferably diminutiv e) portion or subset of an antibody, Fab fragment or peptide that retains binding or effector functions of the parent antibody, Fab fragment or peptide, optionally refernng to the minimally operative amino acid sequence of said antibody, Fab fragment or peptide. The terms "molecular scaffold," "scaffold," and "polymer scaffold" mean a discrete structure or multimolecular structure, preferably a flexible linker molecule, polymer, pair or group of attached molecules, monomers or polymers compnsing a linear, cuned, branched, circular, polygonal, bent, folded, looped, jointed, hinged, resilient, elastic and/or flexible molecule, complex, nanostructure or microstructure, advantageously a molecule, monomer, polymer or pair or group of attached molecules, monomers or polymers compnsing a multimolecular device, paired specific recognition device or tethered specific recognition dev ice. A molecular scaffold compnsing a sy nthetic defined sequence segment is refened to as a "nucleotide-based molecular scaffold" or "nucleotide-based scaffold." A molecular scaffold compnsing an aptamer is refened to as an "aptamenc molecular scaffold" or a "conjugated aptamer." An aptamenc tethered specific recognition device is formed by two members of a nonaptamenc specific recognition pair conjugated to an aptamenc molecular scaffold wherein at least one member of the aptamenc and/or nonaptamenc specific recogmtion pair preferably compnses an effector molecule, e.g., a signal-generating species or a drug. A molecular scaffold compnsing a tethered specific recognition device preferably compnses a bifunctional, tnfunctional or multifunctional, more preferably a heterofunctional, heterobi functional or heterotnfunctional, polymer, copolymer or defined sequence segment. The scaffold is optionally designed, selected or engineered to provide suitable spacing and or flexibility between functional elements (e.g., tethered members of a specific recognition pair) to permit interaction between the functional elements (e.g., specific binding between tethered specific binding partners) under defined conditions, e.g., conditional upon the absence of a dissociative stimulus (e.g., an allostenc ligand or competitor). A molecular scaffold may further compnse or attach to a solid support. The terms "molecular search engine" and "search engine," when used in reference to molecular diversity, diversity space, molecular space, shape space, structural space, surface space, chemical space, catalytic space, surface attractiv uy space, positional space, and the like, means an informational devιce(s) capable ot searching and analyzing information regarding the structure, function and dynamics of molecules and matenals, preferabh an evolving informational system compnsing at least one member of a set of networked, massively parallel informational devιce(s) compnsing pairs of paired informational devices, processors and/or switches. The term "molecular shape" refers to molecular structure and function, particular!} the molecular recogmtion and catalytic recognition properties ot molecules as distinguished from the structure and function of surface features and structural shapes. The term "molecular shape space" refers to the div ersit} oi molecular shape and is equivalent to structure-activity space. "Molecular shape" and "molecular shape space" are used preferentially in certain instances to highlight the molecular recognition properties of individual molecules, as distinct from either 1) structural shapes and recognition properties compnsing specifically attractive surfaces or 2) intermolecular interactions compnsing positional space, particularly the functional coupling achieved b} multimolecular devices of the instant inv ention. The terms "molecular template" and "template" refer to nucleotide-based or nonnucleotide templates. The term "molecule" refers to single atoms, groups of atoms, molecules, compounds, species, free radicals, ions, salts and the like w hich ma} exist as individual molecules, groups of molecules, molecular species, substances or conjugates compnsing molecules "More complementary" means having a greater number of complementan nucleotides. a longer complementary sequence segment, a greater percent base painng or a higher G-C content within a particular sequence segment. The binding between hybndized nucleic acid sequences may be readily reversible, quasirev ersible or virtually ineversible depending, e.g., on the length and G-C content of the hybndized sequence segment, the number of complementary base pairs and the percent base painng. The terms "multimolecular adherent" and "molecular adherent" mean a specific recogmtion device capable of specifically attaching a selected molecule to an amphibious surface or a specifically attractive surface. A multimolecular adherent compnses at least a specific recognition element attached to a first selected molecule, wherein the specific recogmtion element is capable of specifically attaching the first selected molecule to a second selected molecule compnsing an amphibious surface or a specifically attractive surface. In a prefened aspect of the invention, the second selected molecule is a structural molecule compnsing an amphibious surface. In another prefened aspect, the second selected molecule compnses a specifically recognizable surface feature (i.e., structural shape) and the specific recognition element is a shape-specific probe. Recogmtion of a surface feature is preferably referred to herein as specific recogmtion rather than specific binding or molecular recognition. Exceptions are discretionary. The terms "multimolecular adhesive" and "molecular adhesive" mean a multimolecular structure compnsing at least two specific recognition elements capable of specifically attaching two surfaces, at least one surface being an amphibious or specifically attractive surface. A multimolecular adhesiv e compnses at least a biv alent molecule, template or scaffold compnsing or connecting two specific recognition sites, at least one being capable of specifically recognizing a selected molecule and at least one being capable of specifically recognizing an amphibious surface or a specifically attractive surface. Two surfaces can be specifically attached by a single multimolecular structure compnsing a multimolecular adhesive that specifically recognizes two surfaces. Alternatively, two surfaces can be specifically attached by a multimolecular adhesive compnsing a pair or group of molecules or multimolecular structures that each bind a different surface or different molecule capable of attaching to a surface. In this case, the simultaneous or sequential attachment of the molecules or multimolecular structures to the tw o surfaces and to each other (i.e., by self-assembly) results in the formation of multimolecular adhesive that attaches the two surfaces to one another. The term "multimolecular complex" or "multimolecular heteropolymenc complex" refers to a synthetic heteropolymer or multivalent heteropolymenc hybnd structure hav ing at least one identified molecule specifically bound or at least two different aptamer molecules bound to the same target molecule or attached to a common nucleotide spacer, spacer molecule, ohgonucleotide linker or nonnucleotide linker molecule A multimolecular complex compnses at least one synthetic aptamenc defined sequence segment, at least one other defined sequence segment which is a conjugated defined sequence segment or is capable of specific recognition, and at least one specifically attached selected nonoligonucleotide molecule. When used in reference to a complex compnsing a synthetic heteropolymer, the term "multimolecular heteropolymenc complex" is prefened When used in reference to a complex compnsing at least two aptamers, the term "aptamenc multimolecular complex" is also used. Two different aptamer molecules joined to one another either directly or via a linker molecule (i.e., a nucleotide spacer, spacer molecule, ohgonucleotide linker or nonnucleotide linker) to form a discrete structure capable of specifically binding two different nonoligonucleotide molecules may be refened to as either as a synthetic heteropolymer or as an aptamenc multimolecular complex. Similarly, a discrete structure compnsing an aptamenc defined sequence segment attached indirectly via a linker molecule to a second defined sequence segment may be refened to as a synthetic heteropolymer, if the discrete structure is capable of specifically recognizing a first, nonoligonucleotide molecule and of hybndizing a second, ohgonucleotide molecule compnsing a selected nucleic acid sequence. The terms "multimolecular delivery system," "nucleotide-based delivery system," and "nucleotide-based molecular dehvery system," as used herein, refer to discrete structures capable of specifically recogmzing, binding or stonng and transporting, carrying, providing, presenting, dehvenng or releasing a selected molecule or nucleic acid sequence to a selected target, receptor, site, region, proximity or destination. Like multimolecular switches, transducers and sensors, multimolecular delivery systems compnse at least two specific recognition pairs or two defined sequence segments connected and functionally coupled by nucleotide-dependent positioning of the conesponding specific recognition sites. Unlike multimolecular switches, transducers and sensors, however, a prefened embodiment of the multimolecular delivery system provides additive, combined or synergistic functional coupling of a first and second selected molecule or nucleic acid sequence to a third object (i.e., a selected target) compnsing a molecule, group of molecules, process, disease or condition. In other words, a prefened form of functional coupling for multimolecular delivery systems does not involve the exchange of matter or energy between two specific recogmtion pairs connected by nucleotides, but instead relies on the combined binding or activity of two specific recogmtion pairs positioned by nucleotides to modulate the binding or activity of a selected target. The term "multimolecular delivery system" further includes replicates, progeny, impnnts and mimetics of nucleotide-based molecular delivery systems, including nonnucleotide impnnts and mimetics, i.e., nonnucleotide multimolecular delivery systems. The term "multimolecular device" means a novel and useful synthetic multimolecular structure compnsing at least one synthetic defined sequence segment and a second molecule (e.g., a multimolecular switch, transducer, sensor or molecular delivery system, a tethered recogmtion device or a MOLECULAR MACHINE) or, alternatively, a novel and useful replicate, progeny, impnnt or mimetic of a multimolecular structure that compnses at least one synthetic defined sequence segment and a second molecule, e.g., a nonnucleotide impnnt or mimetic of a nucleotide-based multimolecular device. The term "nucleotide-based multimolecular device" refers to synthetic nucleotide-based, aptamer- based or heteropolymer-based discrete structures compnsing at least two molecules and includes, without limitation, nucleotide-based multimolecular switches, multimolecular sensors, multimolecular transducers, multimolecular drug delivery systems, molecular dehveiy systems, multimolecular adhesives, multimolecular adherents and tethered recognition devices. Nucleotide-based multimolecular devices are optionally refened to simply as multimolecular devices. The term "multimolecular device" further includes replicates, progeny, impnnts and mimetics of nucleotide-based multimolecular devices, including nonnucleotide impnnts and mimetics, i.e., nonnucleotide multimolecular devices. A nucleotide or nonnucleotide multimolecular device mav be refened to as a "multimolecular structure" or "multivalent molecular structure." Nucleotide-based multimolecular devices advantageously compnse replicatable nucleotides. The terms "multimolecular drug delivery system" and "multimolecular drug delivery device" refer to a nucleotide-based or nonnucleotide multimolecular device capable of facilitating, enhancing, enabling or modulating the administration, delivery, dosing, safety, efficac}, release, activation, clearance, transport, pharmacodynamics or pharmacokinetics of at least one drug or prodrug administered to or contacting an organism. Advantageously, one drug or prodrug is specifically attached to a first specific recogmtion element (e.g . an aptamer or designer receptor) compnsing the multimolecular drug deliver} system. A second specific recogmtion element compnses or specificalh recogmzes a second drug or prodrug or a selected target. Specific interaction of the second specific recognition element with a selected target results in target-specific deliver}, release and/or activation of the specifically attached drug or prodrug at or near its therapeutic receptor. Alternativel . where the second specific lecognition element compnses or specifically attaches a second drug or prodrug, the multimolecular drug dehv ery system is capable of combination therapy , e.g., delivery of two different drugs to neighbonng therapeutic targets or receptors. A multimolecular drug delivery system may be specifically, covalently, pseudoineversibly or quasirev ersibly conjugated to a biological or biocompatible substance or immobilized to a biological or biocompatible solid support (e.g., a cell, surface, tissue, polymer, device or earner). Useful synthetic solid supports compnsing immobilized multimolecular drug delivery systems include, without limitation, artificial organs, artificial cells, artificial skin, implantable devices, controlled release polymers, gels, foams, insoluble polymers, bioerodible polymers, transdermal devices, pumps, infusion devices, indwelling sensors, vascular grafts, artificial valves, artificial joints, prosthetic devices, endoscopes, optical fibers, imaging devices, ablation devices, catheters, guide ires, surgical equipment, diagnostic dev ices and momtonng devices. Prefened multimolecular drug delivery systems of the instant invention include smaRTdrugs, multimolecular complexes, promolecular delivery devices and tethered recogmtion devices compnsing targeted, tethered or tnggered release prodrug complexes. In a prefened embodiment, designer receptors compnsing multimolecular drug delivery systems are selected for the ability to mimic the specificity of a therapeutic receptor for a drug. The term "multimolecular heteropolymenc complex" means a multimolecular complex compnsing a synthetic heteropolymer, i.e., a multimolecular complex compnsing at least one synthetic aptamenc defined sequence segment, at least one other defined sequence segment which is a conjugated defined sequence segment or is capable of specific recogmtion and at least one specifically attached nonoligonucleotide molecule. The terms "multimolecular lubncant" and "molecular lubncant" refer to a multimolecular structure or multimolecular device that separates two surfaces, preferably amphibious or specifically attractive surfaces, by attaching to one or both surfaces and reduces the fπction, adhesion, traction or direct interaction betw een the surfaces. Separation of the surfaces is achieved by template-directed attachment of a selected molecule, nucleotide or conjugate, preferably a structural molecule (e.g., a fullerene, buckyball, carbon nanotube, carbon nanorod, polymer, surfactant or glass) or an effector molecule (e.g., a colloid, nanosphere, microsphere or molecular ball beaπng) to a first surface. The first surface- attached selected molecule, nucleotide or conjugate may further compnse or attach to a specific recogmtion element (e.g., a ligand, receptor or ohgonucleotide sequence) that is capable of specifically attaching to the second surface, e.g., by specific recogmtion of a selected molecule, selected nucleic acid sequence or surface feature compnsing the second surface. Specific attachment of a multimolecular lubncant to one or both surfaces is advantageously quasireversible, wherein dissociation and reassociation of one or more recognition elements enables movement of the multimolecular lubncant relative to one or both surfaces, i.e., movement of the surface(s) relative to the multimolecular lubncant. The teπn "multimolecular sensor" means a multimolecular device compnsing a sensor, optionally including a multimolecular transducer and'or a multimolecular switch, which is capable of sensing, detecting, measunng, momtonng. determining or quantifying one or more substances, events, activities or properties. The terms "multimolecular structure" and "multivalent molecular structure" refer to a synthetic multimolecular or multivalent nucleotide or nonnucleotide molecule or complex, e.g., a discrete structure, molecular complex, molecule or molecular scaffold compnsing at least two molecules and or two recognition sites attached to one another either noncovalently or covalently . A multimolecular structure compnsing a defined sequence segment (i.e., a nucleotide-based multimolecular structure) is a discrete structure. A multimolecular structure lacking a nucleotide is a nonnucleotide multimolecular structure and is not a discrete structure Multimolecular structures include, without limitation, molecular complexes, conjugates, multivalent templates, multivalent molecules and multivalent molecular scaffolds, aptamenc and heteropolymenc discrete structures, and nucleotide-based and nonnucleotide multimolecular devices. The term "multimolecular switch" means a multimolecular device compnsing at least two defined sequence segments or specific recogmtion pairs capable of participating in stimulus-response coupling. The term "multimolecular transducer" means a multimolecular device capable of performing a desired function, i.e., transducing an input into a desired output, by means of functional coupling between or among two or more selected molecules or between at least one selected molecule and one selected nucleic acid sequence, e.g., by molecular channeling, electronic coupling or energy transfer. The function of a multimolecular transducer depends on additive or partially additive, combined, simultaneous, cooperative or synergistic functional coupling between or among selected molecules and/or selected nucleic acid sequences compnsing or recognized by the multimolecular transducer. The terms "multivalent" and "multisite," when used in reference to nucleotide- based, aptamenc, heteropolymenc and nonnucleotide devices, templates, scaffolds and molecules, means compnsing at least two specific recognition sites. The term "multivalent," when used in reference to a multivalent heteropolymenc hybnd structure, means having at least two specific recogmtion sites in addition to the hybndizable defined sequence segments joining the synthetic heteropohmers that form the multivalent heteropolymenc hybnd structure, i.e.. having at least two available and/or unoccupied valencies. In other words, at least two specific recogmtion sites compnsing a multivalent heteropolymenc hybnd structure are capable of specifically recogmzing selected molecules or selected nucleic acid sequences other than the synthetic heteropolvmers that form the multivalent heteropolymenc hybnd structure itself For example, a multivalent heteropolymenc hybnd structure consisting of two hybndized bifunctional synthetic heteropolvmers is a bifunctional (i.e , bivalent) multivalent heteropolymenc hybnd structure having two available valencies and two hybπdized (i.e., occupied) defined sequence segments. The term "multivalent heteropolymenc hybrid structure" refers to two or more synthetic heteropolvmers hybπdizably linked. Each heteropolymer compnses nucleotides, preferably oligonucleotides, having at least two defined sequence segments A first defined sequence segment of at least one heteropolymer is capable ot specifically binding to a nonoligonucleotide molecule or group of molecules, preferably a receptor, ligand, strucmral molecule or molecular effector. The first defined sequence segments of other synthetic heteropohmers compnsing the multivalent heteropolymenc hybnd structure are capable either of specifically binding to a selected molecule or of specifically binding or hybπdizing to a selected nucleic acid sequence or of positioning a conjugated selected molecule within functional coupling distance of a nonoligonucleotide molecule specifically bound to the first defined sequence segment of the first synthetic heteropolymer. thereby enabling functional coupling between the conjugated selected molecule and the specifically bound nonoligonucleotide molecule. Functional coupling of a conjugated selected molecule includes detection of target molecule binding (i.e., to form a multimolecular complex) by molecular proximity -dependent single- molecule detection. Where the first defined sequence segment of the second synthetic heteropolymer is designed or selected to position a conjugated selected molecule for functional coupling to a specifically bound nonoligonucleotide molecule, the specifically bound nonoligonucleotide molecule is preferably an effector molecule and more preferably a signal-generating species or a drug. The specifically bound nonoligonucleotide molecule is not a ligand or receptor covalently or pseudoineversibly attached to the conjugated selected molecule. In other words, the two defined sequence segments of a bifunctional multivalent heteropolymenc hybnd structure that are specifically bound and/or conjugated to nonoligonucleotide molecules are not directly attached to the same nonoligonucleotide molecule, one specifically and the other covalently or pseudoirreversibly. Nor are they directly attached to the same covalently or pseudoineversibly conjugated pair or group of molecules, e.g., a tightly bound or covalently crosshnked ligand-receptor pair. These defined sequence segments of a bifunctional multivalent heteropolymenc hybnd structure are directly attached to two different molecules, thereby assembling and positiomng the specifically bound molecule and the conjugated molecule for functional coupling. Stated differently, the two different attached molecules are site-specifically attached to two different defined sequence segments of two different, hybndizably linked synthetic heteropolvmers. Second defined sequence segments of the synthetic heteropohmers compnsing a multivalent heteropolymenc hybnd structure are capable of hybπdizing to each other or to a linker ohgonucleotide, optionally forming a double-stranded recogmtion site (e.g., an aptamer, immunoreactiv e epitope or biological recognition site) or intercalation site (e.g., for a drug, a dye or, more generally, an intercalating agent) between the first defined sequence segment of a first s}nthetιc heteropolymer and the first defined sequence segment of a second synthetic heteropoh mer. The terms "multivalent impnnt" and "bivalent impnnt" refer to a bivalent and/or multivalent multimolecular structure compnsing an idiotypic or antndioty pic impnnt, replicate, mimetic, clone or mutant of a multivalent molecular structure or a plurality of positionally ordered molecules compnsmg a multimolecular strucmre or multimolecular device. When used in reference to parent molecule(s) or multimolecular structure^) compnsing a plurality of recognition elements, the terms "multivalent impnnt" and "bivalent impnnt" mean a selected, impnnted, transposed, mimetic or progeny molecule or multimolecular structure compnsing a plurality of antiidiotvpic or idiotypic recogmtion elements capable of recognizing, competing with, crossreacting with, mimicking or approximating the conesponding recognition element(s) of the parent molecule(s) or multimolecular structure(s). In other words, each impnnt or progeny recognition element is either an ldiotype or an antndiotype of a corresponding precursor or parent recogmtion element. When used in reference to impnnting or transposing a parent multivalent template or multimolecular structure having a plurality of recognition elements, "impnnt" and "transposition" refer to a progeny multivalent template or multimolecular structure capable of mimicking the parent or an impnnt of the parent, i.e., the progeny multivalent template or multimolecular strucmre has recogmtion elements that conespond either idiotypically or antudioty'pically to each recogmtion element of the parent multivalent template or multimolecular structure. The term "multivalent molecular structure" means a multimolecular structure. The term "mutation," when used in reference to transposing, transforming, impnnting or mimicking a nonnucleotide molecule or selected population of nonnucleotide molecules refers to a vanation or change in structure, shape, activity , function, properties or diversity of the product compared to the precursor, e.g., an approximation or vaπant rather than a perfectly faithful impnnt or copy. The terms "native," "in nature", "natural," "naturally occurnng," "biological" and "organism," refer to spontaneously occurnng substances or beings that are not willful products of human-directed recombinant or transgenic technologies. In the case of hybnd plants and animals that have been identified and or perpetuated by cross-breeding, selective breeding, cross-pollination, stem or limb grafting and the like, the terms "native," "in nature", "natural," "naturally occurnng," "biological" and "organism" mean and include only heretofore known strains. Where the distinction between natural and synthetic is ambiguous, a heretofore known substance, being or strain shall be considered natural for purposes of this disclosure, and a heretofore unknown substance, being or strain shall be considered synthetic. The term "networked," when used in reference to search engines, means multiple interconnected informational devices compnsing an informational system. The informational system preferably compnses multiple application-specific search engines functionalh coupled to one another and to an information source, e.g., a database compnsing known information. The term "nonaptamenc," when used in reference to a nucleotide-based multimolecular device, means a discrete structure that does not compnse a nucleotide sequence heretofore known to be an aptamer. The term "nonaptamenc," when used in reference to a multimolecular structure, means a nonnucleotide multimolecular structure or a nucleotide-based multimolecular structure (i.e., a discrete structure) which is not known to compnse an aptamer or to rely on the recognition properties of an aptamer. In the event a nucleotide sequence compnsing a nucleotide-based multimolecular structure is subsequenth discovered to compnse a previously undiscovered aptamer, the multimolecular strucmre is considered to be a nonaptamenc multimolecular strucmre, unless and until the aptamenc sequence ot the multimolecular structure specifically recogmzes its target under conditions of use, thereb} forming a multimolecular structure compnsing an aptamer-target complex. A nonnucleotide multimolecular structure is also a nonaptamenc multimolecular structure. When used in reference to a multimolecular device, the term "nonaptamenc" similarly means a nonnucleotide multimolecular device or a nucleotide-based multimolecular device which is not kno n to compnse an aptamer or to rely on the recogmtion properties of an aptamer. In the e ent a nucleotide sequence compnsing a nucleotide-based multimolecular device is subsequentiy discovered to compnse a previously undiscovered aptamer, the multimolecular device is considered to be a nonaptamenc multimolecular device, unless and until the aptamenc sequence of the multimolecular device specifically recognizes its target under conditions of use, thereby forming a multimolecular device compnsing an aptamer-target complex. A nonnucleotide multimolecular device is also a nonaptamenc multimolecular device. The term "nonaptamenc multimolecular device" refers to a nucleotide-based or nonnucleotide multimolecular device (e.g., a multimolecular switch, multimolecular sensor, multimolecular transducer, multimolecular deliver}' system, paired specific recogmtion device, tethered specific recognition device, multimolecular adherent, multimolecular adhesive, molecular adsorbent or MOLECULAR MACHINE) w hich does not compnse a known and/or operative aptamer. A nucleotide-based nonaptamenc multimolecular device compnses either 1) at least two different specific binding pairs connected by a single defined sequence segment, each specific binding pair being attached in a controlled manner to a defined site or nucleotide position or 2) at least two different defined sequence segments and at least two different specific binding pairs, each specific binding pair being conjugated to a different defined sequence segment, wherein the two conjugated defined sequence segments are h}bndιzed to a linker ohgonucleotide which thus joins and positions the two conjugated defined sequence segments within a single discrete structure or 3) at least two members of a specific binding pair or four members of two specific recogmtion pairs covalently or pseudoine ersibly attached to a molecular scaffold. Nonaptamenc multimolecular devices that do not compnse a nucleotide are nonnucleotide multimolecular devices and include. e.g., nonnucleotide paired specific recogmtion dev ices, nonnucleotide tethered specific recognition devices, nonnucleotide molecular adsorbents and nonnucleotide multimolecular adherents, multimolecular adhesives, multimolecular switches, multimolecular sensors, multimolecular transducers and multimolecular delivery s} stems. The term "nonnucleic acid molecule" means a molecule or group of molecules that is not a nucleic acid. The terms "nonnucleotide" and "nonnucleotide molecule," when used in reference to a molecule, residue, moiety or group, means the molecule, residue, moiety , or group in question is not a nucleotide. When used in reference to an amphibious surface, the term "nonnucleotide" means the surface does not compnse a heretotore known nucleotide-based molecular recognition partner unless and until modified b} a multimolecular device of the instant invention. A nonnucleotide amphibious surface modified by a nucleotide-based multimolecular device of the instant invention is refened to as an amphibious surface or a nucleotide-based amphibious surface. The term "nonnucleotide library" means a mixture ot molecules which does not compnse nucleotides or a hbrary that is not a nucleotide library , or a pair, group or library of hbranes that are not nucleotide hbranes. Typically, nonnucleotide hbranes of the invention are diverse mixtures of molecules of a particular nonnucleotide t}pe or class, e.g., peptides, proteins, small molecules, hpids, carbohydrates, acrylates, polyalcohols, polyesters, polystyrenes, polyolefins, glycols, dendrons, antibodies, amino acids, engineered antibodies, ohgosacchaπdes, and organic polymers such as polyhydroxyalkanoates, polyphenols. poylphosphates and polysulfates. The terms "nonnucleotide multimolecular device" and "nonnucleotide-based multimolecular device" mean a multimolecular device that does not compnse a synthetic heteropolymer, aptamer or defined sequence segment. The term "nonnucleotide surface," when used in reference to an amphibious surface, means a surface that does not compnse a heretofore known nucleotide-based molecular recognition partner unless and until modified by a multimolecular dev ice of the instant invention. A nonnucleotide amphibious surface modified by attachment of a nucleotide-based multimolecular device of the instant invention may be refened to as an amphibious surface or a nucleotide-based amphibious surface. The terms "nonoligonucleotide" and "nonoligonucleotide molecule" mean a molecule or group of molecules which is not an ohgonucleotide or, m the case of a conjugate compnsing a first molecule that is an ohgonucleotide attached to a second molecule that is not an ohgonucleotide, the portion ot the conjugate onginating trom or consisting of the second molecule. The terms "nucleic acid amplification" and "nucleic acid amplification system" refer to processes and/or reagent means for amplifying nucleotides, including, without limitation, biological, enzymatic, in vivo, in vitro and in situ methods relying on thermal cycling, isothermal methods, clomng, nucleotide vectors, parasites, self-sustained reactions and the like, e.g., PCR, LCR, Q-beta rephcase, 3SR, TAS, RCR, CPR, πbonuclease H and reAMP methods. The term "nucleic acid molecule" refers to biological, naturally occurnng, nonbiological and synthetic nucleotides, oligonucleotides and selected nucleic acid sequences which may optionally be conjugated to one or more nonoligonucleotide molecules. The term "nucleohbrary-directed" refers to a product or process compnsing, relating to or depending on from screening and/or selection of a nucleotide library, preferably a paired library compnsing a nucleotide hbrary functionalh coupled to a nonnucleotide hbranes. The terms "nucleoplastic" and "plasticity," when used to descnbe synthetic nucleotides, nucleotide hbranes, progemc molecules, segments, templates, progeny, mimics, impnnts, clones, conjugates, copies, simulations, modifications and products and progeny therefrom, refers to the diversity of members of the set of all nucleoplastic hbranes compnsing nucleotide and nonnucleotide hbranes and paired hbranes, also refened to herein as (libraries) , wherein the composition and/or sequence, if applicable, of a heretofore unknown plastic nucleoprobe becomes known following library selection. The terms "nucleoplastic library," " nucl eodi verse library," "nucleotide library" and "(hbraπes) N " refer to the set of all possible pairs of parent and progeny molecular hbranes compnsing a first member which is a nucleotide library and a second member which is a nonnucleotide library, wherein the first and second hbranes are capable of being functionally coupled, including the set of all molecular hbranes and members of molecular hbranes that evolve from said parent or progeny molecular hbranes. The terms also refer, as the case may be, to any set or subset of plastic segments or templates and any set or subset of hbranes compnsing a nucleoplastic library. The term "nucleoprobe" reters to a nucleotide compnsing a specific recogmtion element or, in the case of a plastic nucleoprobe, a parent nucleotide, replicate, progeny, impnnt or mimetic compnsing a specific recognition element. Nucleoprobes include, without limitation, nucleotide-based specific recogmtion elements and synthetic heteropolvmers, multimolecular devices, impnnts, progeny, replicates and mimetics compnsing or onginating from at least one nucleotide-based recogmtion element. The term "nucleotide" includes nucleotides and nucleotide analogs, preferably groups of nucleotides compnsmg oligonucleotides, and refers to any compound containing a heterocyclic compound bound to a phosphorylated sugar by an N-glycosyl link or any monomer capable of complementary base painng or any pohmer capable of hybndizing to an ohgonucleotide. The term "nucleotide analog" reters to molecules that can be used in place of naturally occurring bases in nucleic acid synthesis and processing, preferably enzymatic as well as chemical synthesis and processing, particularly modified nucleotides capable of base painng and optionally synthetic bases that do not compnse adenine, guanine, cytosine, thymidine, uracil or minor bases. This term includes, but is not limited to, modified punnes and pynmidines, minor bases, convertible nucleosides, strucmral analogs of punnes and pynmidines, labeled, denvatized and modified nucleosides and nucleotides, conjugated nucleosides and nucleotides, sequence modifiers, terminus modifiers, spacer modifiers, and nucleotides with backbone modifications, including, but not limited to, nbose -modified nucleotides. phosphoramidates, phosphorothioates, phosphonamidites. methyl phosphonates, methyl phosphoramidites, methyl phosphonamidites, 5'-β-cyanoethyl phosphoramidites, methylenephosphonates, phosphorodithioates, peptide nucleic acids, achiral and neutral internucleotidic linkages and nonnucleotide bndges such as polyethylene glycol, aromatic poly amides and pids. These and other nucleotide and nucleoside denvatives, analogs and backbone modifications are known in the art (e.g., Piccinlh J.A. et al. (1990) Nature 343.33-37; Sanghvi et al (1993) In. Nucleosides and Nucleotides as Antitumor and Antiviral Agents, (Eds. CK. Chu and D.C. Baker) Plenum, New York, pp. 311-323; Goodchild J. (1990) Bioconjugate Chemistry 7: 165-187; Beaucage et al. (1993) Tetrahedron 49: 1925- 1963). The term "nucleotide-based," when used in reference to a multimolecular device, multimolecular switch, multimolecular transducer, multimolecular sensor, multimolecular delivery system, multimolecular drug delivery system, tethered recogmtion device or molecular scaffold, means compnsing at least one defined sequence segment. The teπn "nucleotide catalyst" means a synthetic nucleotide or nucleotide-encoded nonnucleotide molecule compnsing a catalytic recogmtion partner, preferably a nucleic acid, nucleotide or nonnucleotide molecule identified by screening and selection of a preferably diverse mixture compnsing nucleic acid molecules, nucleotides, modified nucleotides or nucleotide-encoded nonnucleotide molecules, advantageoush a diverse hbran compnsing soluble, conjugated or immobilized molecules. The term "nucleotide-dependent functional coupling" means functional coupling between or among nucleotide or nonnucleotide molecules which depends on or is brought about b} attachment of at least one molecule to at least one nucleotide compnsing a discrete structure. The terms "nucleotide-dependent molecular positiomng," "nucleotide-dependent positiomng" and "nucleotide-positioned" means molecular positioning that depends on either 1) attachment of a molecule or group to a nucleotide compnsing a defined sequence segment or 2) attachment of a molecule or group to a defined sequence segment compnsing a nucleotide or 3) attachment of a molecule or group to a nucleotide compnsing a defined sequence segment compnsing a nucleotide-based multimolecular device, wherein the position ot the attached molecule or group depends on the position ot the nucleotide compnsing the defined sequence segment or the position ot the defined sequence segment compnsing the multimolecular device. The terms "nucleotide-directed," "nucleotide-ordered," and "nucleotide template- ordered" refer to nucleotide-dependent molecular positioning, nucleotide-dependent functional coupling and/or the preparation, properties and use of multimolecular devices. Nucleotide-ordered multimolecular devices include nucleotide and nonnucleotide replicates, clones, mimetics, impnnts, progem and conjugates of nucleotide-ordered multimolecular devices, including replicates, clones, mimetics, impnnts, progen} and conjugates thereof and progen} therefrom. The term "nucleotide library" means a hbran , paired hbran or group of hbranes compnsing nucleotides or nucleotide mimetics, including, without limitation, nucleic acid hbranes, nucleotide hbranes, modified nucleotide hbranes, hbranes compnsing nucleotide analogs or nucleotide mimetics, nucleotide-encoded hbranes, nucleotide-ordered molecular hbranes, paired nucleotide hbranes, nucleotide-nonnucleotide libraries, hbranes of nucleotide hbranes, hbranes of hbranes compnsing nucleotides or nucleotide hbranes, and any hbran compnsing nucleotide and nonnucleotide molecules, wherein a nucleotide molecule compnses, attaches to or is capable ot attaching to a nonnucleotide molecule. The terms "nucleotide ligand" and "nucleotide receptor" refer to molecules or functional groups compnsing or attaching to modified nucleotides, denvatized nucleotides, nucleotide analogs, nucleotide-encoded molecules or nucleotide-encoded chemical, shape or sequence hbranes. Nucleotide ligands and nucleotide receptors are preferably denvatized monomers, optionally dimers or tnmers, selected for the ability to specifically recognize an identified molecule or structural shape. Specific recogmtion properties are residue-dependent or modification-dependent, as distinct from sequence-dependent aptamer-based specific recogmtion. Preferabh , a nucleotide ligand or nucleotide receptor compnsing a denvatized nucleotide is selected for the ability to specifically recognize an identified molecule that is not heretofore known to specifically recognize the undenvatized nucleotide. In other words, specific recogmtion is a property of the denvative or denvatized nucleotide, not the undenvatized nucleotide. Thus, a nucleotide receptor that is a member of a first specific binding pair (i.e., the nucleotide receptor and its ligand) may also be a member oi a second specific binding pair, e.g., the nucleotide receptor ma} be specifically recognized by a receptor (e.g., an antibody) or an aptamer. In other words, a nucleotide receptor may also be a ligand. Conv ersely, a nucleotide hgand may also be a receptor Where there is overlap or potential ambiguity in the use of these terms, "nucleotide hgand" and "nucleotide receptor" ma} be used interchangeably. The term "nucleotide mimetic" means a nucleotide analog or a nonnucleotide molecule capable of being replicated by nucleic acid cloning, replication or amplification methods know n in the art, i.e., a nucleotide analog or a molecule capable ot mimicking a replicatable nucleotide. The term "nucleotide-nonnucleotide" reters to a pair compnsing a first nucleotide or nucleotide-based member and a second nonnucleotide or nonnucleotide-based member A "nucleotide-nonnucleotide library" or "paired nucleotide-nonnucleotide hbran" is a paired library compnsing a nucleotide library functionalh coupled to a nonnucleotide hbran. The terms "nucleotide or nonnucleotide," "nucleotide and nonnucleotide," "nucleotide-based or nonnucleotide" and "nucleotide-based and nonnucleotide," when used in reference to methods, compositions and devices disclosed herein, mean consisting of or compnsing an} type of molecule, i.e., nucleotide and/or nonnucleotide molecules. The term "nucleotide space" means the dimensionless product oi all molecular and surface diversity spaces encompassed by all nucleotide hbranes, including members of molecular hbranes and surface hbranes compnsing or attaching to members oi nucleotide hbranes The terms "nucleotide spacer" and "spacer nucleotide" reier to one or more nucleotides, spacer arms, spacer molecules or groups selected or designed to join at least two nucleotides, defined sequence segments and/or a nucleotide and a nonnucleotide molecule, preferably to alter or adjust the distance between the two nucleotides, defined sequence segments and/or nucleotide and nonnucleotide molecules, and include individual nucleotides, groups of nucleotides, nucleotide analogs, modified nucleotides, spacer modifiers, spacer sequences, spacer molecules, linker molecules, linker oligonucleotides, nonnucleotide linkers and mutually hybndizable defined sequence segments compnsing synthetic heteropolvmers, multivalent heteropolymenc hybnd structures, discrete heteropolymenc structures and nucleotide-based multimolecular dev ices. Nucleotide spacers may also compnse contiguous or interspersed groups oi molecules compnsing a defined sequence segment or joining two defined sequence segments and may advantageously compnse replicatable nucleotides. The term "nucleotide template" means a defined sequence segment capable of attaching at least two selected molecules to one another, wherein the template is capable ot specifically binding at least one of the selected molecules. The other selected molecule may be specifically bound, covalently attached or pseudoirreversibly attached to the template. Also included are nucleotide and nonnucleotide clones, replicates, mimetics, impnnts, progeny and conjugates of nucleotide templates, including clones, replicates, mimetics, impnnts and conjugates thereof and progeny therefrom. The term "ohgonucleotide" means a naturally occurnng or synthetic polymer of nucleotides, preferably a polymer compnsing at least three nucleotides and more preferably a polymer capable of hybndization. Oligonucleotides may be single-stranded, double- stranded, partially single-stranded or partialh double-stranded nbonucleic or deoxynbonucleic acids, including selected nucleic acid sequences, heteroduplexes, chimenc and hybndized nucleotides and oligonucleotides conjugated to one or more nonoligonucleotide molecules. The terms "ohgonucleotide conjugate" and "conjugated ohgonucleotide" mean an ohgonucleotide conjugated to, incorporating or compnsing a nonoligonucleotide molecule or a nonoligonucleotide molecule covalently or pseudoine ersibh attached to an ohgonucleotide. The term "paired nucleotide-nonnucleotide library" means a paired library compnsing a nucleotide library functionally coupled to a nonnucleotide library . The term "paired nucleotide-nonnucleotide mapping hbran " refers to a mapping library compnsing a paired nucleotide-nonnucleotide library, i.e., a paired nucleotide- nonnucleotide hbran compnsing a plurality of selected recogmtion partners identified, collected or accumulated b} screening and/or selection of at least one impnnt hbran. preferably a plurality ot impnnt hbranes, to map, impnnt, transpose, ev aluate or charactenze the recognition properties of a pluralit} of target molecules, preferabh a selected population of selected molecules. The terms "paired recognition pair" and "paired recognition device" mean a multimolecular strucmre compnsing at least two different recogmtion pairs, each recognition pair compnsing two members. The terms "paired specific recognition pair," "paired specific recognition device," "paired molecular recogmtion pair" and "paired molecular recognition device" mean a synthetic multimolecular structure compnsing at least two different specific recogmtion pairs conjugated to a molecule, synthetic nucleotide, or molecular scaffold or compnsing a nucleotide-based multimolecular device, each specific recogmtion pair compnsing two specific recogmtion partners. Advantageously, the specific recognition pairs are positioned for functional coupling by site-directed attachment to the same molecule, molecular scaffold or nucleotide, e.g., the binding or activity of a member of one specific binding pair can modulate the binding or activity of a member of the other specific binding pair. Paired specific recogmtion devices include, without limitation, heteropolymenc, aptamenc, nonaptamenc and nonnucleotide multimolecular devices compnsing at least two different specific recognition pairs and multimolecular structures capable of mimicking multimolecular devices compnsing at least two different specific recogmtion pairs, including replicates, impnnts, mimetics and progen} thereof . Biological proteins, antibodies, and heretofore known bispecific, bivalent and multivalent synthetic, recombinant and engineered antibodies, antibody fragments, peptides, proteins, bactenophage, immunoadhesins and fusion proteins are not paired specific recogmtion devices. The term "paired templates" means at least two templates that are related to one another as parent and progeny or by one or more c}cles of replication, transcnption, conjugation, cloning, impnnting or transposition, transformation, projection, reflection or passage through a nucleotide hbran, optionally a paired nucleotide-nonnucleotide library. The term "pair of specific recogmtion pairs" means two different specific recognition pairs. The terms "pair ot specific binding pairs" and "paired specific binding pair" refer to a pair of specific recognition pairs whose members are capable of specific binding or structural shape recognition (i.e., any form of specific recogmtion except h}bndιzation). "Paired specific binding pairs" means the specific binding pairs compnse a paired specific recognition device, i.e., they are attached to a common molecule, molecular scaffold or nucleotide, adv antageously within functional coupling distance. The terms "payload" and "payload molecule," when used in reference to a promolecular delivery device or promolecule complex, mean a nucleotide or nonnucleotide molecule specifically attached to a designer receptor, i.e., a specific recognition partner of a designer receptor. Payload molecules may include, without limitation, selected molecules, nucleotides. selected nucleic acid sequences, structoral shapes and surface features. Deliver} of a payload molecule to a selected target by a promolecular delivery device provides a desired result caused or mediated by the binding or activity of the payload molecule at or near the selected target or by interaction between payload and target molecules. The term "photosystem" as used herein means a photosynthetic molecule or group of molecules that senes as a functionally coupled energy transfer acceptor from a reaction center and includes, without limitation, molecules compnsing photosystem I and photosystem II. The term "plastic," when used in reference to segments, templates, hbranes, recogmtion elements, MOLECULAR MACHINES and the impnnting, transposition and transformation of recogmtion elements, templates, molecular media, matenals, surface features and MOLECULAR MACHINES, refers to plasticity, i.e., compnsing, relating to or onginating from a diverse mixture, medium, hbrary, population, source, mateπal, process or set of alternatives, preferably a diverse library, a paired library or a library of hbranes, more preferably a nucleotide library. Alternatively, when used to descnbe heretofore known industnal matenals (i.e., plastics), the term "plastic" means the family of cast and mold substances available for use in product design and commercial manufactunng, typically polymers capable of being shaped, formed, molded, extruded, cast into shapes or films, or drawn into filaments. The terms "plastic nucleoprobe" and "nucleoplastic probe" refer to 1) a specific recogmtion element compnsing a parent nucleotide or a replicate, progeny, impnnt or mimetic thereof or 2) a specific recogmtion element selected from a nucleotide hbrary, optionally a paired nucleotide-nonnucleotide library, including replicates, progeny, impnnts or mimetics thereof. The terms "polydiverse" and "nucleodiverse," when used in reference to a mixture, library or molecular medium, refer to multidimensional diversity in structure-activity space, preferably diversity in at least three dimensions, e.g., a nucleotide library diversified in chemical space, sequence space and positional space. The term "positional space" refers to the two-dimensional positional relationships between and among members of pairs and groups of molecules compnsing or attaching to nucleotide-defined positions of multisite templates, including impnnts, progeny, replicates and mimetics of nucleotide-based templates. Positional space is approximated as the dimensionless product oi possible positional relationships of Z recognition elements compnsing X sequences of Y length, i.e., the combinatonal product of diversities compnsing 1) vanable sequence length and 2) vanable distance between two recogmtion elements compnsing a sequence and 3) vanable distance between a third recogmtion element compnsing a sequence and each of two optionally preselected and positionally fixed recogmtion elements and 4) vanable distance between an Nth recogmtion element compnsing a sequence and each of N-1 optionally preselected and positionally fixed recognition elements. Positional space as used herein does not reier to the axial, polar or three-dimensional position oi nonnucleotide groups tethered to nucleotides compnsing nucleotide ligands. nucleotide receptors, modified nucleotides, selected molecules conjugated to nucleotides, nucleotide-encoded chemical groups, and the like, which three- dimensional diversity is a subset of molecular shape space. Instead, positional space is a representation of the diversity space reflecting potential interactions between at least two recognition elements compnsing either a nucleotide or an impnnt, progeny or mimetic of a nucleotide. Sequence length is included as a dimension in positional space substantially to emphasize the bookend utility of 3' and 5' nucleotide modifications in mapping the positional preference landscape of first and second selected molecules (e.g., ligands, receptors and effector molecules) compnsing, attached or tethered to members of nucleoplastic hbranes. The user-definable distance between 3' and 5' ends of a nucleotide strand provides a convenient tool for mapping the "proximity space" or "functional coupling space" of a selected pair of selected molecules (e.g., donor and acceptor fluorophores) from a first plastic medium (e.g., a nucleotide library) into a second plastic medium (e.g., selectable nonnucleotide molecules or polymers, i.e., peptides, phosphohpids, polyacrylate) The terms "precursor," "substrate" and "product," w hen used in reference to functionally coupled hbranes, are introduced herein as useful metaphors in respect of conesponding terms used to descnbe functionally coupled paired efiectors compnsing, e.g., enzymatic, photonic and electronic donor and acceptor species. A precursor library is capable of donating (i.e., providing or compnsing) a member, property, activity or specificity that can be recognized or impnnted by a member compnsing an acceptor library.. The terms "probe" and "probing," when used to descnbe a selected molecule, segment, template, nucleotide or library, refer to a specific recognition element or a plurality of specific recogmtion elements. Unlike pnor art nucleic acid probes, the probes compnsing synthetic heteropolvmers, multimolecular devices and MOLECULAR MACHINES may specifically recogmze nucleotide or nonnucleotide molecules or structoral shapes The term "prodrug" means a drug, drug precursor or modified drug that is not fully active or available until converted in vivo or in situ to its therapeutically active or available form. Prodrugs compnsing multimolecular devices and MOLECULAR MACHINES of the instant invention include targeted and tnggered-release prodrug complexes, e.g., multimolecular drug delivery systems and promolecular delivery devices. The term "prodrug complex" refers to a promolecule complex or pay load- receptor complex compnsing a drug specifically attached in inactiv e or unav ailable form to a designer receptor, whereupon dissociation of the drug from the designer receptor renders the drug molecule active or available for interaction with a selected target or pathophysiological receptor. Prodrug complexes may compnse a pair or plurality ot drugs specifically bound to a pair or plurality of designer receptors. Prodrug complexes may also be operativ ely attached to biological or biocompatible structures, microstructures or nanostructures free to distnbute in or to one or more anatomical or physiological compartments. Useful synthetic solid supports compnsing immobilized prodrug complexes include, without limitation, artificial organs, artificial cells, artificial skin, implantable devices, controlled release polymers, gels, foams, insoluble polymers, bioerodible polymers, transdermal devices, pumps, infusion devices, indwelling sensors, vascular grafts, artificial valves, artificial joints, prosthetic devices, endoscopes, optical fibers, imaging devices, ablation devices, catheters, guidewires. surgical, diagnostic and momtonng devices. Usetul synthetic solid supports compnsing immobilized multimolecular drug delivery systems include, without limitation, artificial organs, artificial cells, artificial skm, implantable devices, controlled release polymers, gels, foams, insoluble polymers, bioerodible polymers, transdermal devices, pumps, infusion devices, indwelling sensors, vascular grafts, artificial valves, artificial joints, prosthetic devices, endoscopes, optical fibers, imaging devices, ablation devices, catheters, guidewires, surgical equipment and in vivo, in situ and extracorporeal diagnostic, momtonng and delivery devices. Prodrug complexes may also attach to solid tissues or anatomically confined biologic or biocompatible structures, or they may be illfully attached to cells, tissues or organs, optionally reversibly or by a willfully biodegradable, cleavable and or metabohzable linkage. Prodrug complexes may be stored, confined or released in selected physiological or anatomical compartments or, alternativ ely, transported, delivered and or confined to a selected physiological or anatomical compartment, site or target. The term "progeny," when used in reference to a molecule, nucleotide, segment, template or group of molecules, nucleotides, segments or templates, means onginating ultimately from a replicatable synthetic nucleotide (i.e., a parent) either by replication, clomng, amplification, modification, impnnting or transposition. The parent synthetic nucleotide and progeny nucleotide or nonnucleotide molecules, segments, templates or progeny therefrom may be enzymatically, chemically or physically modified, denvatized, impnnted, transposed, replicated, cloned, simulated, copied, approximated, conjugated, complexed, assembled, amplified, mutated and the like, all with v anable and preferably willful control over the fidelity of the replication, impnnting, simulation and/or modification process. The term "promolecular dehvery device" means a targeted and/or tnggered-release (i.e., smart) molecular delivery system compnsing a bivalent or multivalent molecule, template, scaffold or multimolecular device capable of specifically recognizing, stoπng, preserving, stabilizing or attaching a payload molecule and/or carrying, transporting, dehvenng, releasing, activating or attaching the payload molecule to or near a selected target. The payload molecule is specifically attached in inactive and/or unavailable form to a designer receptor, providing a complex referred to herein as a "promolecule complex," "payload-designer receptor complex" or "payload-receptor complex." Upon dissociation of the payload-receptor complex, the released payload molecule becomes active or available for interaction ith a selected target. A promolecular delivery dev ice iurther compnses a second, optionally allosteπc, recogmtion site capable of dehvenng, attaching, activating and/or releasing the payload molecule to or near a selected molecule, surface feature or selected nucleic acid sequence compnsing, attaching to or neighbonng the selected target. The payload molecule can also be tethered to a molecule or scaffold compnsing or attaching to the designer receptor, providing a tethered promolecular delivery device. In this mode of operation, the payload molecule is not only specifically attached, but also pseudoineversibly or covalently attached (i.e., tethered) to the designer receptor, optionally in a selectively cleavable manner (e.g., cleavable by enzymatic, catalytic or photodynamic degradation of a selected covalent bond). The term "promolecule," when used in reference to a promolecule complex or molecular delivery system, means a nucleotide or nonnucleotide molecule or group of molecules having a selected property, structure, function or activ lty that is not expressed, active or available unless or until the molecule or group of molecules is released or activated, i.e., by dissociation from a promolecule complex. The terms "promolecule complex," "payload-designer receptor complex" and "payload-receptor complex" refer to a molecular complex compnsing a promolecule or payload molecule specifically attached in inacti e or unavailable form to a designer receptor, whereupon dissociation of the payload molecule from the designer receptor renders the payload molecule acti e or available for interaction with a selected target. The terms "proximity space" and "functional coupling space," when used in reierence to plastic nucleoprobes, templates and nucleotide hbranes, refer to the structural and functional conelates of positional space with respect to the ability oi at least two molecules or groups to interact in a functionally coupled manner, e.g., as donor and acceptor species compnsing a functionally coupled donor-acceptor pair. The term "pseudoineversible" means a binding event, bond, association, complex or specific recogmtion pair compnsing a selected molecule which cannot be dissociated, displaced, rev ersed, separated or detached under normal conditions of use and w hich is not iormed dunng operation, as distinct trom manufacture, oi a multimolecular structure or multimolecular device. For purposes of the present invention, noncovalent, pseudoineversible attachment of a selected molecule to a multimolecular device is functionally equivalent to covalent attachment in terms of the stability and permanence of attachment, so long as the pseudoineversibly attached molecule is attached dunng multimolecular device manufacture and remains inseparable dunng device operation. An unconjugated ohgonucleotide hybndized to a defined sequence segment of a multimolecular device is said to be hybndized, not pseudoirreversibly attached, regardless of the melting temperature oi the hybndized duplex. Pseudoineversible attachment of selected molecules may be achiev ed by a number of methods well known in the art, preferably by av ldin/biotin or streptav ldin/biotin conjugation or by hybndization of conjugated defined sequence segments having a high degree of complementan ty (i.e., to form a stable hybnd), and iurther including, without limitation, ionic bonding, surface adsoφtion, intercalation, tnplex formation, chelation, coordination, hydrophobic binding and high-affinity specific binding, optionally followed by UV irradiation or treatment with a noncovalent stabilizer, covalent crosshnking reagent and/or photoactivatable reagent. Pseudoinev ersible attachment may also be achieved by threading a πng-shaped or circular molecule (e.g., a rotaxane) with a linear molecule (e.g., a polymer with knotted or bulky ends) or by caging or entrapping a guest molecule using, e.g., a sphencal or hollow polymer, host or cage molecule (e.g., a cyclodextπn). Noncovalent, site-specific conjugation of a selected molecule to a multimolecular device may be accomplished by pseudoineversible attachment, preferably by hybndization of an ohgonucleotide conjugate to a defined sequence segment or by specific binding of an avidin or streptavidin conjugate to a biotinylated molecule or defined sequence segment. A member of a molecular recogmtion pair that specifically binds or hybndizes a selected target (e.g., a clinical analyte) dunng multimolecular device operation is not considered pseudoirreversibly attached to the selected target, even if both members are required for device function, e.g., as may be the case with a conjugated specific binding pair compnsing a multimolecular sensor. A target nucleic acid sequence detected by hybndization to a DNA probe compnsing a multimolecular sensor, for example, is considered hybndized to the multimolecular sensor, not pseudoirreversibly attached. The term "quasireversible," when used in reference to specific recogmtion, means specific binding, hybndization or shape-specific recogmtion that, following association, can be dissociated, displaced or reversed under conditions of use. Quasireversible attachment means specific attachment and/or noncovalent attachment. The term "reaction center" means a natural or synthetic photosynthetic molecule or group of molecules in which photoinitiated electron transfer culminates in a relatively long- lived, charge-separated state. The term "receptor" means a selected nonoligonucleotide molecule capable of specifically binding to a ligand by affinity-based interactions that do not involve complementary base painng. Whereas a ligand and its corresponding receptor are refened to herein as members of a specific binding pair, complementary nucleic acid sequences are simply reiened to as "complementary" or "hybndizable" or "members oi a molecular recognition pair." "Receptors" include, but are not limited to, biological, synthetic or engineered membrane receptors, hormone receptors, drug receptors, transmitter receptors, autacoid receptors, phero one receptors, stimulus-response coupling or receptive molecules, antibodies, antibody fragments, engineered antibodies, antibody mimics or mimetics, molecular mimics, molecular impnnts, molecular recogmtion units, adhesion molecules, agglutinins, lectins, selectins, cellular receptors, avidin and streptavidin, and congeners, analogs, competitors or denvatives of these molecules as well as nonoligonucleotide molecules selected, e.g., by combinatonal methods and/or library screening, to specifically bind other selected molecules and conjugates formed b} attaching any of these molecules to a second molecule. Receptors further include selected molecules capable of specificalh recognizing structoral molecules, effector molecules and selectable molecules compnsing ligands. The term "recogmtion," when used in reference to molecular diversity or structore- shape-activity space or when used without classification as specific recognition, molecular recogmtion, catalytic recogmtion or structural shape recognition, includes all forms of recognition disclosed in the instant application, including molecular recogmtion, structural shape recogmtion, catalytic recogmtion and specific surface attractivity. "Molecular recogmtion" means specific binding or hybndization. "Specific recogmtion" means molecular recognition, structural shape recognition or specific attractivity. "Recognition" means specific recogmtion or catalytic recognition, i.e., specific binding, hybndization, structural shape recogmtion, catalytic recogmtion or specific surface attractivity. The terms "recognition element," "recogmtion partner," "recogmtion molecule" and "recogmtion." when used to descnbe a nucleotide, segment, template or selected molecule compnsing a multimolecular structure, synthetic heteropolymer, multimolecular device or MOLECULAR MACHINE, refers to a molecule, residue, sequence or group that is capable of recognizing another molecule, residue, sequence or group or a structural shape or surface feature by molecular recognition, structural shape recogmtion or catalytic recognition. Recognition elements include, without limitation, ligands, receptors, selected nucleic acid sequences, defined sequence segments and replicates, clones, mimetics, recognition partners and impnnts thereof and progeny therefrom. When used in reference to an impnnt of a first (i.e., pnnt, parent or idiotype) recogmtion element compnsing a first (i.e., pnnt, parent or idiotype) multimolecular structure, the terms "recogmtion element" and "recogmtion site" mean a second (i.e., impnnt or progen}) recogmtion element compnsing a second, different multimolecular structure, wherein the second, progen} recognition element is either an idiotype or antiidiotype that is capable of either mimicking or recogmzing the first, parent recogmtion element. The progeny recognition element may be a first, second or subsequent generation impnnt or impnnted impnnt, idiotype or antiidiotype, mimetic or antimimetic of the first, parent recogmtion element, all of which generations are referred to herein as impnnts. The teπn "recognition site" means a recognition element compnsing a site, position, functional group, molecule, residue or sequence compnsing, e.g., a template, scaffold, multimolecular structure or multimolecular device. The terms "recognize" and "recognition," when used in reference to a surface feature or structural shape, include specific attractivity, structural shape recognition and catalytic recognition. The terms "replicatable nucleotide" and "replicatable nucleotide sequence," when used in reference to a synthetic nucleotide, defined sequence segment, selected nucleic acid sequence, linker ohgonucleotide, spacer nucleotide, aptamenc. heteropolymenc or nucleotide-based multimolecular device, mean a nucleotide, nucleotide analog, nucleic acid, defined sequence segment or discrete structure that can be cloned, replicated, amplified, transcnbed or copied, preferably by enzymatic and/or biological methods known in the art. Replicatable nucleotides include RNA, DNA, chimenc, parent and progeny nucleotide sequences compnsmg or complementary to a selected parent or progeny nucleotide, including conesponding RNA, DNA or chimenc sequences (e.g., a DNA sequence corresponding to an RNA parent or an RNA sequence corresponding to a DNA parent) which can be replicated, transcnbed or amplified either in vivo or in vitro. The term "replicatable sequences of nucleotides," when used in reference to a synthetic heteropolymer or multimolecular device, means any RNA or DNA or chimenc nucleotide sequence compnsing or complementary to a synthetic heteropolymer and any conesponding RNA or DNA or chimenc sequence (e.g., a DNA sequence corresponding to an RNA synthetic heteropolymer or an RNA sequence corresponding to a DNA synthetic heteropolymer) which can be replicated or amplified either in vivo or in vitro. "RT," as used in "smaRTdrug," is an abbreviation for "receptor-tπggered," "receptor- targeted" or, as the case may be, "receptor-tethered." Receptor-tnggered, receptor- targeted and receptor-tethered mechanisms refer not only to receptors compnsing selected nonoligonucleotide molecules, but also to specific recogmtion partners compnsing nucleotides, e.g., nucleotide ligands, nucleotide receptors, defined sequence segments and selected nucleic acid sequences. In other words, the abbreviation "RT" reters to products and processes compnsing designer receptors. "SAS" is an acronym for "structure- activity space." The term "selectable," when used in reference to a molecule, sequence or surface feature, refers to a substance or property that is knowable but heretofore unknown or unidentified, i.e., discoverable or identifiable. Selectable molecules, sequences and surface features are preferably discovered or identified by screening and/or selection of a library. The terms "selected" and "identified," when used in reference to a surface, feature, structure or shape (e.g., an attractive surface, surface feature, structure or structural shape), refer to surface features that can be specifically recognized by a shape-specific recogmtion partner, i.e.. a shape-specific probe. "Selected molecules" or "identified molecules," also refened to herein as "selected nonoligonucleotide molecules" and "identified nonoligonucleotide molecules," are nonoligonucleotide molecules which include, but are not limited to, receptors, ligands, structoral molecules and effector molecules which may exist as single molecules, conjugates or groups of molecules, multimolecular structures or multimolecular devices, including mimetics, impnnts and conjugates of any of these molecules, and mimetics, impnnts and conjugates thereof. Selected molecules also include library -selected molecules, e.g., unknown or unidentified nucleotide ligands, nucleotide receptors, modified nucleotides. nucleotide analogs, shape recogmtion molecules and nonoligonucleotide molecules identified or discovered by screening and selection of nucleotide and nonnucleotide hbranes and nucleotide-encoded chemical hbranes. In other words, selected molecules include selectable molecules that are knowable but heretofore unknown or unidentified, i.e., molecules that remain to be discovered or identified. When used in reference to a conjugate compnsing a first molecule that is an ohgonucleotide attached to a second molecule that is not an ohgonucleotide, the terms "selected molecule," "identified molecule," "selected nonoligonucleotide molecule" and "identified nonoligonucleotide molecule" refer to the portion of the conjugate onginating from or consisting of the second molecule. "Selected nucleic acid sequences" include, but are not limited to, defined sequence segments of synthetic heteropolvmers and discrete structures, heteropolymenc, aptamenc and nonaptamenc nucleotide-based devices, oligonucleotides, and RNA, DNA or denatured RNA or DNA sequences, including wild-type, mutant and recombinant biological nucleic acid sequences; biological, recombinant, engineered and synthetic nucleic acids compnsing specific or catalytic recogmtion sites or properties, e.g., aptamers, catalytic DNA, πbozymes, nucleic acid ligands, nucleic acid receptors, nucleic acid antibodies and nucleic acid molecules capable of participating in specific recogmtion, catalytic and enzymatic reactions; genomic, plasmid, cellular and transcnbed or complementary nucleic acids, including DNA, cDNA and RNA; natural and synthetic coding, noncodmg, initiation, termination, promoter and regulatory sequences, including natural, synthetic, native or normative biological recogmtion sites and therapeutic targets; natural and synthetic oligonucleotides with defined topology, secondary or tertiary structure or three-dimensional shape, including rolling and circular nucleic acids, nucleic acid loops, stems, bulges, knots, pseudoknots, polygons, spheres, pyramids, cubes, and higher order three-dimensional shapes; immobilized, conjugated, labeled and lnsolubihzed nucleic acids, including nucleic acids hybndized or specifically bound to other soluble, insoluble, immobilized, conjugated or labeled nucleic acids; nucleic acid probes, targets and templates; sense, antisense and antigene nucleic acid strands; conjugated defined sequence segments and conjugated oligonucleotides, including oligonucleotides that are internally conjugated to prov ide closed- loop, single-ended or double-ended loop structures; branched, branched-chain, branched- comb, multi-chain and "Chπstmas tree" oligonucleotides; nucleic acid dendrons, dendnmers and nucleic acid conjugates formed by coulombic, affinity- based or covalent interactions with dendrons, dendnmers and other branched and hyperbranched structures; nucleotides compnsing or capable of forming single-stranded, double-stranded, partially single- stranded, partially double-stranded, heteroduplex, tnplex, quadruplex, chimenc and hybnd structures compnsing natural or synthetic RNA, DNA or oligonucleotides compnsing nucleotide analogs, denvatized nucleotides, nucleosides, nucleoside phosphates or backbone modifications. Selected nucleic acid sequences hybndized to bifunctional synthetic heteropohmers do not include unconjugated pnmers that hybndize to fixed pnmer-annealing sequences of aptamers selected from mixtures of random-sequence nucleic acids. The terms "selected target," "selected target molecule" and "targeted molecule" refer to a nucleotide or nonnucleotide molecule or group of molecules compnsing a target or an identified member of a recogmtion pair (e.g., a selected molecule, selected nucleic acid sequence, recognizable surface feature, selectable molecule or selectable surface feature), an identified composition, process, disease or condition, or the object, acceptor or substrate of a selected molecule (e.g., an enzyme, drug, dye, energy or electron donor) or desired result (e.g., catalysis, labeling, energy transfer or electron transfer) and include nucleotide and nonnucleotide molecules, structural shapes and surface features. The terms "selected target molecule" and "selected target," when used in reference to the process of identifying a recognition partner, e.g., by selecting a single synthetic nucleotide molecule capable of recognizing the selected target or by screening and selection of a library, means an identified or known target molecule for which a recognition partner is being sought. A selected target may be a heretofore unknown target, so long as the target is selectable (i.e., discoverable) and is identified at the time a recogmtion partner for the target is selected. Selected targets include, e.g., targets, aptamer targets, therapeutic targets, target molecules, targeted molecules and sequences, selected molecules, target sequences, selected nucleic acid sequences and specifically attractive surface features. The term "selection of a recognition property," when used in reference to a surface library, structure library or mateπal library, means identifying one or more structural shapes or surface features capable of recognition, preferably structural shape recogmtion or catalytic recogmtion. The term "sensor" means and includes any device capable of sensing, detecting, measunng, momtonng, determining or quantifying one or more substances or events including, ithout limitation, mechanical sensors, force and mass sensors, velocity sensors, pressure sensors, acoustic sensors, temperature and thermal sensors, chemical sensors, biosensors, electrochemical sensors, optical sensors, electromagnetic sensors, electπcal sensors, electronic sensors, optoelectronic sensors, motion sensors, photodetectors, gas sensors, liquid sensors, liquid and solid level sensors as well as multimolecular devices and tethered recognition devices of the instant invention, e.g., multimolecular sensors and multimolecular switches. Sensors of the invention further include devices which compnse, attach, are functionally coupled to or are capable of functionally coupling to MOLECULAR MACHINES ot the invention, optionally paired MOLECULAR MACHINES or systems compnsing pairs or networks of paired MOLECULAR MACHINES. A multimolecular sensor is a multimolecular device capable of sensing, detecting, measunng, momtonng, determining or quantifying one or more substances or events or a sensor compnsing a multimolecular device. The term "shape," when used in reference to a surface, structure or shape-specific recogmtion element, means structural shape, as distinct from molecular shape. The term "shape recogmtion library" means a preferably diverse mixture of molecules synthesized, collected or pooled for library selection of one or more shape- specific recognition elements, e.g., a shape-specific probe or shape recognition template. The term "shape-specific" reters to specific recognition of a structural shape compnsing a chemically bland or specifically attractive surface by a shape recogmtion element, herein a neighboπng or distant region of the surface having the same chemical composition as the specifically recogmzed structural shape is not recogmzed by the shape recognition element. In other words, specific recogmtion of the structural shape by a shape- specific recognition element is not competitively inhibited by another surface or region that is heretofore chemically indistinguishable from the specifically recogmzed structural shape. The terms "shape-specific probe," "shape- specific partner," "shape-specific recogmtion element," "shape-specific element," "shape-specific molecule" and "shape- specific recogmtion" refer to a nucleotide-based or nonnucleotide specific recogmtion partner of a structoral shape, specifically attractive structure, surface or surface feature. A shape- specific probe and the conesponding specifically recogmzed structural shape are members of a specific recogmtion pair. The terms "shape-specific template" and "shape recogmtion template" mean a bivalent or multivalent template compnsing at least one shape-specific probe. The terms "signal -generating molecule" and "signal-generating species" refer to a selected molecule, species or group compnsing selected molecules capable of generating a detectable signal or enhancing or modulating the detectabihty of a substance or transducing an energy, activity, output or signal of a substance into a qualitatively, quantitatively or detectably different energy, activity, output, signal, state or form. Signal-generating species include, but are not limited to, molecules, groups of molecules, conjugates and complexes compnsing detectable (and optionally dyed, modified, conjugated, labeled or denvatized) tags, tracers, radioisotopes, labels, reporters, polymers, hght-ha esting complexes, antenna structures, natural and synthetic and biomimetic photosynthetic molecules, reaction centers, photosystems. signal transduction pathways, molecular cascades, macromolecules. microparticles. nanoparticles, colloids, metals, dyes, fluorophores, phosphors and other photon-absorbmg, photon-emitting and photosensiti e molecules, including molecules or groups that enhance, attenuate, modulate or quench the photon-absorbing or photon-emitting properties of another molecule or group, energy transfer donors and acceptors, enzymes, coenzymes, cofactors, catalytic antibodies, synthetic enzymes and catalysts, molecular mimics and mimetics, luminescent, tnboluminescent, sonoluminescent, electroluminescent, chemiluminescent and bioluminescent molecules, electron transfer donors and acceptors, oxidizing and reducing compounds, mediators and other electroactive molecules, metabolic, photoactive, signaling and signal processing molecules used to capture and transduce energy in biological and biomimetic processes and systems, optionally including natural, synthetic or mimetic scaffold, organizational and coupling molecules, chaperones and accessory biological or biomimetic molecules or groups of molecules inv oh ed in the transduction of a first iorm oi energy or information into a second torm oi energy or information. The term "single-molecule," as used in reference to single-molecule detection, single-molecule isolation, single-molecule charactenzation, single-molecule identification. single-molecule amplification and single- molecule sequenαng. relates to an individual or selected molecule, an individual pair or group of molecules or selected molecules attached to one another or an individual molecular complex, supramolecular assembly, discrete structure or multimolecular structure. When used in reference to single molecules and single-molecule detection, the term "molecule" means an individual molecule, selected molecule, discrete structure, multimolecular structure, complex or conjugate compnsmg a selected molecule, nucleotide, pair or group of molecules and not an indefinite plurality of molecules, e.g., an unknown and/or uncountable number of molecules. The terms "single-molecule detection" and "smgle-molecule detection method" refer to a method capable of detecting an individual or selected molecule, an individual pair or group of molecules or selected molecules attached to one another, a molecule or multimolecular structore attached to a surface feature or an indiv ldual molecular complex, supramolecular assembly, discrete structure or multimolecular structure. Molecules detectable by single-molecule methods include nucleotide and nonnucleotide molecules, conjugates, complexes, selectable and selected molecules, selectable and selected nucleic acid sequences and replicates, impnnts, clones, mimetics, conjugates and progeny thereof. Single-molecule detection methods and devices of the instant invention include, without limitation, optical force fields, optical tweezers, optical trapping, laser scanning and laser trapping; scanning probe techmques including scanning probe microscopy , scanning tunneling microscopy, scanning force microscopy, atomic force microscopy, scanning electrochemical microscopy and hybnd scanning probe techniques; spectroscopy , kromoscopy and mass spectrometry; capillary electrophoresis, microelectrophoresis, on-chip electrophoresis and multiplexed and anayed electrophoretic methods and detectors; microminatuπzed and nanofabπcated optical, spectroscopic, spectrometπc, electrochemical, optoelectromc and electronic detectors; microsensors, nanosensors and integrated on-chip detectors, sensors, transducers and arrays; molecular detectors, sensors and transducers; and multimolecular devices compnsing multimolecular sensors, multimolecular switches, multimolecular transducers and tethered recognition devices. The term "site," when used in reference to a molecule, polymer, template, scaffold, multivalent molecular structore, multimolecular device or MOLECULAR MACHINE, means a chemical group, functional group, charged group, electrostatic field, three-dimensional shape, docking surface, residue, position, moiety, atom, group of atoms, topological location, region, defined sequence segment, nucleotide, functional element or recognition partner. When used in reierence to a recogmtion site compnsing a recognition partner, e.g., a catalytic site, specific binding site, hybndization site or shape recognition site, the term "site" means the operative binding element, recognition element or docking surface compnsing the recognition partner. The terms "site-specific," "site-directed" and "regiospecific," when used in reference to attachment to or modification of a molecule or group of molecules, mean covalent or noncovalent attachment at chemically, functionalh or topologicalh defined sιte(s). Site-specific and site-directed attachment typically imply attachment to a particular chemical moiety, residue, reactive group, specific recognition site or epitope, while regiospecific attachment typically relates to the topological position, region or portion of a molecule or surface occupied by an attached species rather than the particular chemical site. However, the art recognizes some overlap between these terms. The term "smart" refers to a multimolecular structure or multimolecular device capable of performing a useful function in response to a selected target or stimulus through the combined actions of at least two different functional elements, e.g., a recognition element and an effector element. For example, a smart polymer may compnse a first (e.g., structoral) element that changes shape in response to interaction oi a second (1 e., recogmtion) element with a selected target or stimulus. Smart multimolecular devices oi the instant invention include, without limitation, promolecular delivery devices, multimolecular drug delivery systems, multimolecular sensors, multimolecular switches, multimolecular transducers, tethered recogmtion devices, multimolecular lubncants, molecular adhesives. molecular adherents and smaRTdrugs. The term "smaRTdrugs" refers to smart multimolecular drug delivery systems, promolecular delivery devices and tethered recogmtion devices having utility in human and vetennary medicine compnsing at least a designer receptor and a second recognition site compnsing a targeting site, a tnggered release or activ ation site, an allostenc site, or a tethered recognition pair, optionally a cleavably tethered recognition pair Prefened smaRTdrug compositions of the inv ention compnse multimolecular drug delivery systems, tethered molecular dehv ery dev ices, receptor- targeted prodrugs and tnggered release prodrug complexes The term "solid support" means a composition compnsing an immobilization matnx, insolubilized substance, solid phase, surface, substrate, layer, coating, transducer, transducer surface, woven or nonwoven fiber, matnx, crystal, membrane, hposome, vesicle, gel. sol, colloid, insoluble pohmer, plastic, glass, biological or biocompatible or bioerodible or biodegradable polymer or matnx, suspension, precipitate, microparticle or nanoparticle Solid supports include, for example and without limitation, monolayers, bilayers. vesicles, liposomes, cell membranes, fixed cells, commercial membranes, resins, matnces, fibers, separation media, chromatography supports, hydrogels, foams, polymers, plastics, glass, mica, gold, beads, microspheres. nanospheres. silicon, gallium arsenide, organic and inorgamc metals, semiconductors, insulators microstructures and nanostructures Microstructures and nanostructures include, without limitation, microminiatunzed, nanometer-scale and supramolecular probes, tips, bars, pegs, plugs, rods, sleev es, wires, filaments, tubes, ropes, tentacles, tethers, chains, capillanes, vessels, walls, edges, corners seals, pumps, channels, lips, sippers, lattices, trellises, gnds, arrays, cantilevers, gears, rollers, knobs, steps, steppers, rotors, arms, teeth, ratchets, zippers, fasteners, clutches, beanngs, sprockets, pulleys, levers, inclined planes, cords, belts, cams, cranks, wheels, axles, rotating wheels, springs, nuts, screw s, bolts, shafts, pistons, cylinders, beanngs, motors, generators, gates, locks, keys, solenoids, coils, switches, sensors, transducers, actuators, insulators, capacitors, transistors, resistors, semiconductors, diodes, electrodes, cells, antennae, appendages, cages, hosts, capsules, sieves, coatings, knedels, ultrafine particles, powders and micromachined and nanofabncated substrates, surfaces, layers, films, polymers, membranes and parts, including stationary, mobile, attached, tethered, ratcheted and robotic structures, devices, machines, components, elements and features. Solid supports useful in drug delivery compnse, tor example and without limitation, artificial organs, artificial cells, artificial skm, implantable devices, controlled release polymers, gels, foams, insoluble polymers, bioerodible polymers, transdermal devices, pumps, infusion dev ices, indwelling sensors, vascular grafts, artificial valves, artificial joints, prosthetic devices, endoscopes, optical fibers, imaging devices, ablation devices, catheters, guidewires, surgical equipment and diagnostic dev ices. The term "spacer molecule" refers to one or more nucleotide and/or nonnucleotide molecules, groups or spacer arms selected or designed to join two nucleotide or nonnucleotide molecules and preferably to alter or adjust the distance between the two nucleotide or nonnucleotide molecules. The term "spacer nucleotide" means a nucleotide spacer compnsing a nucleotide, i.e., a nucleotide spacer that is a nucleotide or joins at least two nucleotides or compnses a sequence of nucleotides, e.g., a defined sequence segment. The terms "specifically attach," "specific attachment" and "specifically recognize" refer to specific recogmtion and include specific binding, hybndization, structural shape recognition and specific attractivity. The terms "site-specifically attach," "site-specific attachment" and "attachment site" refer to site-directed covalent and/or noncovalent attachment by methods including, but not limited to, specific recogmtion. The terms "specifically attractive," "specifically attractive surface," "specific attractivity" and "specific surface attractivity," when used in reference to a surface, structure, surface feature or structoral shape, mean specifically recogmzable by a shape-specific recognition partner, i.e., a member of a specific recognition pair compnsing a shape-specific element, shape-specific molecule, shape-specific partner or shape-specific probe. The term "specifically recognizable," when used in reference to a surface or structure, means a specifically attractive surface compnsing a surface ieature or structural shape capable of being specifically recognized by a shape-specific recognition partner, i.e., a shape-specific element, shape-specific molecule, shape-specific partner or shape-specific probe. The term "specific binding" reters to a measurable and reproducible degree of attraction between a ligand and a receptor or between a defined sequence segment and a selected molecule or selected nucleic acid sequence. The degree of attraction need not be maximized to be optimal. Weak, moderate or strong attractions may be appropnate for different applications. The specific binding which occurs in these interactions is well known to those skilled in the art. When used in reference to synthetic defined sequence segments, synthetic aptamers, synthetic heteropolvmers, nucleotide ligands, nucleotide receptors, shape recogmtion elements, specifically attractive surfaces and MOLECULAR MACHINES disclosed herein, the term "specific binding" may include specific recognition of structural shapes and surface features. Otherwise, specific binding refers explicitly to the specific, satorable, noncovalent interaction between two molecules (i.e., specific binding partners) that can be competitively inhibited by a third molecule (i.e., competitor) shanng a chemical identity (i.e., one or more identical chemical groups) or molecular recognition property (i.e., molecular binding specificity) with either specific binding partner. The competitor may be, e.g., a crossreactant, analog or congener of an antibody or its antigen, a ligand or its receptor, or an aptamer or its target. Specific binding between an antibody and its antigen. for example, can be competitively inhibited either by a crossreacting antibody or by a crossreacting antigen. By contrast, surface-specific attachment ot a shape-specific probe to a structural shape (e.g., a surface feature of a silicon or carbon surface) cannot be competitively inhibited by amoφhous silicon or carbon. Shape-specific surface recogmtion does not involve specific binding or molecular binding specificity as defined herein Howe er, the term "specific binding" may be used for con enience to approximate or abbrev late a subset oi specific recognition that includes both specific binding and structoral shape recognition. Specific binding between a ligand and receptor means affinity -based interaction related to the secondary, tertiary and quaternary structure and charge of the participating molecules and does not include the h} bndization oi complementan nucleic acid sequences due to Watson-Cnck base painng. When used in reference to a defined sequence segment, the term "specificalh binding to a selected nucleic acid sequence" means a measurable and reproducible degree of attraction between the defined sequence segment and a selected nucleic acid sequence which may involve h} bndization if participating sequences are complementary or alternative mechanisms if sequences are noncomplementary. Where the attraction between nucleotide sequences is known to depend on complementan base painng, binding is preferably refened to as "hybndization." Where the attraction does not depend on complementary base painng, binding between nucleotide sequences is refened to as "specific binding," "specific recogmtion" or "molecular recogmtion." Nonh} bndization - based specific binding between noncomplementary nucleic acid sequences depends not on base painng. but on the secondary, tertian' and quaternan structures and electrostatic fields compnsing participating sequences. Nucleic acid binding reactions known to involve mechanisms other than hybndization include, e.g., antisense, tnplex. quadruplex and aptamer interactions. When used in reference to an aptamer, the term "specific binding" means recogmtion of the aptamer target and does not refer to a nucleic acid sequence capable of hybndizing to the aptamer or a ligand or receptor capable of specifically binding to a corresponding receptor or ligand conjugated to or incorporated in the aptamer, e.g., a particular nucleoside, deπvative, analog, modified nucleotide, nucleotide ligand, nucleotide receptor, conjugated nucleotide or conjugated selected molecule compnsing the aptamer. The term "specific binding" may in some instances be used as an abbreviation for the phrase "specific binding and structoral shape recogmtion." Although "specific binding" differs from "structural shape recognition" as defined herein, the terms may in some cases be used interchangeably or inclusively for clanty or convenience. The term "specific binding pair" means two specific binding partners that specifically bind to one another, e.g., a ligand and its receptor or an aptamer and its target. The terms "specific binding partner" and "specific binding pair" mean a ligand capable ot specifically binding a receptor, an aptamer capable of specifically binding an aptamer target, a defined sequence segment capable of specifically binding a selected molecule, or a defined sequence segment capable of specifically binding a selected nucleic acid sequence and does not include hybndized, hybndizable or complementary nucleic acid sequences. The term "specific binding partner," when used in reference to an aptamer, means the aptamer target and does not refer to either 1) a nucleic acid sequence capable oi hybndizing to the aptamer or 2) a ligand or receptor capable oi specifically binding to a receptor or ligand compnsing the aptamer. e.g , a particular nucleoside, nucleotide, analog, denvative, modified nucleotide, conjugated nucleotide, nucleotide hgand or nucleotide receptor "Specific binding partner" and "specific binding pair" may also be used as abbreviations tor the phrases "specific binding or structoral shape recogmtion pair" and "specific binding or structural shape recognition partner " Although a "specific binding partner" diiiers irom a "structural shape recogmtion partner" as detined herein, the terms may in some cases be used interchangeably or inclusively for clanty or convenience The terms "specific recogmtion," "specific recognition pair" and "specific recognition partner" mean and include specific binding, hybndization, structural shape recogmtion and specific attractivity. The terms "specific recognition pair" means two specific recogmtion partners that specifically recognize one another. The terms "specific shape recognition," "shape-specific recognition," "shape recognition," "surface recognition" and "surface feature recogmtion" mean capable oi discnminating one structural shape or surface ieature from another. Discnminating means binding a first surface ieature and not binding a second suriace ieature having the same chemical composition. Perfect specificity is not required. A certain degree ot nonspecific surface association may be expected, as occurs with specific binding and hybndization reactions. The practical limits on achievable discnmination by shape-specific recogmtion relate to the precision of nanostructure synthesis and surface labncation techniques (e.g , surface machining, molecular and atomic-scale assembly, nanofabπcation, mechanochemical synthesis and preparation of diamondoid matenals and nanostructures, e.g., fullerenes, nanorods and nanotubes) and the punty, affinity, stability and reproducibihty of shape- specific probes. "SASS" is an acronym for "structure-activity-surface space" which reters to the combinatonal product of structure-activity space (SAS) and structural shape space (SSS). Symbolically, SASS = SAS x SSS = space. "SECM" is an abbreviation for "scanning electrochemical microscopy." "SPM" is an abbreviation for "scanning probe microscopy." "SSS" is an acronym for "structural shape space" w hich is equivalent to surface attractivity space. "STM" is an abbreviation for "scanning tunneling microscopy." The terms "stimulus-response coupling" and "stimulus-responsive" refer to functional coupling between or among molecules, wherein an input of matter or energy (i.e., a stimulus) to a first defined sequence segment, selected molecule or specific recognition pair results in a stimulus-specific, effector-mediated response at or by a second defined sequence segment, selected molecule or specific recognition pair. The effector-mediated response may result from the binding or activity of a selected molecule compnsing an effector molecule or a functional element compnsing a nucleotide or nonnucleotide molecule, e.g., an enzyme, nbozyme, conjugate, impnnt or mimetic. The term "stimulus-specific" means that a definitive effector-mediated response is elicited only by stimuli compnsing a specified type or group of molecules or form or level of energy or combination thereof and is not intended or know n to be elicited by unspecified molecules or energies. The terms "structural attractivity" and "surface attractivity " refer to specific recognition of a nucleotide or nonnucleotide molecule by a surface feature or structural shape, optionally a surface feature or structural shape compnsing a chemically bland or amphibious surface. A structurally attractive surface compnses a surface feature or structural shape which is a specific recognition partner of a shape recogmtion molecule (i.e., a shape- specific probe or shape recognition element). The terms "structoral attractivity space," "surface space" and "matenals space" refer to selectable recogmtion properties of chemically bland or amphibious surfaces, matenals, structures structural shapes, surface features and matenal substrates, as distinct from the molecular recognition properties of selected molecules and selected nucleic acid sequences. The term "structural molecules" refers to selected nonoligonucleotide molecules that may lack heretofore known specific binding or effector properties and includes, but is not limited to, selected molecules compnsing structoral shapes and surface features and selected molecules compnsmg elements, atoms, molecules, ions, and compounds compnsing surfaces, amphibious surfaces, inorganic and organic matenals such as carbon, silicon, glass, organic and inorgamc crystals, selected solvents, selected solutes, natural, biomimetic and synthetic nanostructures and microstructures. fibers, filaments, silks, molecular scaffolds, nanotubes, nanorods, fullerenes, bucky balls, diamondoid molecules, semiconductors, insulators, metals, plastics, elastomers, polymers, detergents, lubncants, waxes, oils, powders, fillers, excipients, fibers, tableting ingredients, packaging matenals, papers, industnal plastics, cyclic and polycyclic molecules, dendrons, dendnmers, electrolytes and polyelectrolytes, salts, hydrocarbons, ceramics and biological, biocompatible, biomimetic, biodegradable and impnntable monomers, multimers and polymers, e.g., fatty acids, hpids, surfactants, amino acids, peptides. proteins, polyamines, polyacids, sugars, starches, cellulose, glycosylated molecules, glycopolymers and conjugates thereof The terms "structoral shape," "structural feature," "surface feature" and "surface shape" refer to natural, synthetic, designed or selected surfaces or structures having a two- dimensional or three-dimensional shape, contour, texture, charactenstic, pattern, distnbution, property, configuration, anangement, organization, order, lack of organization or order, torm, trait or pecuhaπty that can be specifically recogmzed by a shape-specific recognition element. The terms "structoral shape recognition," "shape recognition," "shape recogmtion partner," "shape recognition probe," "shape probe" and "surface feature recognition," when used in reierence to a matenal, surface, surface feature, structure or structoral shape, refer to specific recognition of a structural shape or surface feature. The term "structure-activity space," also refened to herein as "art-accepted molecular diversity" or "molecular diversity," means the diversity space compnsing the set of all molecules, known and unknown, net ot the diversity space of specifically attractive surfaces (i.e . structural shapes and surface features). The combinatonal product of structure-activ ity space (SAS) and structural shape space (SSS) is the set of all heretofore known and unknown (molecular and surface) div ersity spaces and is refened to herein as "molecular space," "diversity space" or simply "space." Symbolically, SAS x SSS = space. The term "structure-activity-surface space" (SASS), also refened to as "structure- activity -shape space," refers to the dimensionless combinatonal product of molecular recogmtion space, catalytic recognition space, surface recognition space and surface attractiv ity space, i.e.. all forms of recogmtion disclosed herein Structure-activ ity-surface space is equivalent to the combinatonal product of structure-acti ity space and structoral shape space, I e., SASS = SAS x SSS = space. The terms "substrate" and "matenal substrate," when used in reference to matenals, surfaces and surface space, refer to a substratum, structural layer or toundation, as distinct from an enzyme substrate, and do not relate to catalytic recogmtion. A matenal substrate may, however, optionally compnse an enzyme substrate or catalytic recogmtion property. Advantageously, novel catalytic and molecular recogmtion properties can be confened on heretofore chemically bland substrates by transposition through a nucleotide library, preferably a paired nucleotide-nonnucleotide library. The term "surface" means a boundary in two-dimensional or three-dimensional space. When used in reference to a molecular adsorbent, multimolecular adhesive or multimolecular adherent, the term "surface" means an amphibious surface, a chemically bland surface or a specifically attractive surface. The terms "surface feature" and "specifically attractive surface feature" refer to a structural shape or structural feature of a specifically attractive surface, i.e., a specifically recogmzable structural feature of a surface. Surface features include natural, synthetic, designed or selected structures or surfaces, preierably subnanometer- to submicron-sized surface contours, having a two-dimensional or three-dimensional shape, contour, texture, charactenstic. pattern, distnbution, property, configuration, arrangement, organization, order, lack oi organization or order, form, trait or pecuhanty that can be specifically recognized by a shape-specific recognition element. The terms "surface library," "structure library " and 'matenal hbrary " reier to a random or nonrandom assortment of structural shapes or surface features compnsing a structure, surface or matenal or a random or nonrandom assortment of structures, surfaces or matenals The teπn "surface template" means a template specifically attached by one recognition element to a surface in such manner that a second recognition element is displayed on the surface in a prei erred onentation, i.e . an oπentation enabling the second recogmtion element to effectively and efficiently perform a desired function Desired functions include, e.g., solid phase catalysis, separations, multimolecular synthesis punfication and/or detection of selected molecules, and scanning, imaging and/or charactenzation of displayed recognition elements by an analytical system, e.g., STM, optical scope, laser scanning device or hybnd system. The teπn "synthetic," when used to descnbe a defined sequence segment, means nonnaturally occurnng, i.e., the defined sequence segment is not heretofore known to occur in natore (sans human biotechnologic intenention) and is not heretofore known to be a biological recognition site. The term "synthetic," when used in reference to a synthetic heteropolymer, means that 1) the synthetic heteropolymer is not deπved from a heretofore known biological organism and 2) the nucleotide sequence ot the synthetic heteropolymer is not heretoiore known to occur in nature and 3) at least one defined sequence segment compnsing the synthetic heteropolymer is selected irom a source other than a heretotore known biological organism, biological polymer or collection ot biological polymers and 4) the nucleotide sequence of at least one defined sequence segment compnsing the synthetic heteropolymer is not heretofore known to occur in natore. At least one defined sequence segment of a synthetic heteropolymer is typically selected either 1) from an expenmental or willfully designed mixture, population, pool, library or assortment oi sequences, preierably a diverse mixture, population, pool, library or assortment or 2) by means of a computer simulation, model, search engine or virtual expenment or 3) by in vitro evolution or directed evolution. In each case, the selection cπteπa are established to identify sequences capable of either specifically binding to a selected nonoligonucleotide molecule or nucleic acid sequence or hybπdizing to a selected nucleic acid sequence or positiomng a conjugated molecule (e.g., by hybndization, ligation or specific binding of a conjugate or ab initio synthesis of a synthetic heteropolymer compnsing a conjugated defined sequence segment) within functional coupling distance of a selected molecule capable ot specifically binding another defined sequence segment and/or w ithin suitable proximity ot the selected molecule to enable single-molecule detection The term "synthetic aptamer" means an aptamer or aptamenc sequence that is not heretofore known to occur in nature and i unction as a biological recogmtion site or an aptamer conjugate The term "synthetic deiined sequence segment" reters to a nonnaturally occurnng defined sequence segment, meaning either 1) a defined sequence segment which is not a biological recogmtion site and hose nucleotide sequence is not heretofore known to occur in nature (I e , sans genetic engineeπng) or 2) a conjugated defined sequence segment, w herein the corresponding unconjugated sequence segment is not a biological recogmtion site for the conjugated molecule or 3) a sequence of nucleotides compnsing a modified nucleotide nucleotide analog, nucleotide hgand, nucleotide receptor or nucleotide catalyst When used in reference to a synthetic heteropolymer or aptamenc dev ice, the term "synthetic defined sequence segment capable ot specifically binding to a selected molecule," means a synthetic aptamer Where a nonaptamenc nucleotide-based multimolecular dev ice is capable ot specifically binding a selected molecule, the operative recogmtion element is not an aptamer, but a defined sequence segment conjugated to a specific binding partner, e g , a ligand, receptor or modified nucleotide, optionally a nucleotide hgand or nucleotide receptor The term "synthetic heteropolymer" means a nonnaturally occurnng heteropolymer, and refers to nucleotides, particularly nucleic aαds and replicatable nucleotides (including partially and fully double-stranded and single-stranded nucleotides, synthetic RNA, DNA and chimenc nucleotides, hybnds, duplexes, heteroduplexes, and any πbonucleotide, deoxynbonucleotide or chimenc counteφart thereof and or conesponding complementary sequence, promoter or pnmer-annealing sequence needed to amplify, transcπbe or replicate all or part oi the synthetic heteropolymer), hav ing at least t o defined sequence segments, wherein at least one deiined sequence segment per discrete structure is a synthetic defined sequence segment capable of specifically binding (or shape-specifically recogmzing) and optionally cov alently attaching a selected nonoligonucleotide molecule or group of molecules The second defined sequence segment is capable of either specifically binding (or shape-specifically recognizing) and optionally covalently attaching a different, selected nonoligonucleotide molecule or selected nucleic acid sequence or of hybndization or oi positiomng a conjugated molecule within suitable distance oi a selected molecule specifically bound to a first defined sequence segment to enable single-molecule detection or iunctional coupling between the conjugated molecule and the selected molecule In other words, a synthetic heteropolymer compnses at least a synthetic aptamenc first defined sequence segment which is capable of specific recognition and a second defined sequence segment which is a conjugated defined sequence segment or is capable of specific recognition Where a second defined sequence segment is designed or selected to position a conjugated molecule for functional coupling to a specifically bound selected molecule, the selected molecule is preferably an effector molecule and more preferably a signal-generating species or a drug. A convenient method to position a molecule conjugated to one defined sequence segment for functional coupling to a selected nonoligonucleotide molecule specifically bound to another defined sequence segment of a synthetic heteropolymer involves 3' and/or 5' end-labeling of a defined-length sequence, particularly 5'-end labeling. The efficiency of functional coupling (i.e., the distance between attached selected molecules) can then be adjusted by varying the length of the conjugated defined sequence segment (and optionally the composition of the lntenening nucleotide sequence). Defined sequence segments internally labeled or modified at defined nucleotide positions can also be used to effectively position conjugated selected molecules. In this case, functional coupling efficiency is optimized by adjusting the conjugation position of the selected molecules. Where the second defined sequence segment is designed or selected to position a conjugated molecule within suitable proximity of a specifically bound molecule to enable single- molecule detection (e.g., Example 16, vide infra), the conjugated molecule compnses a selected molecule, preferably an effector molecule, macromolecule, group of molecules or signal-generating species. A multisite heteropolymer selected from a random-sequence nucleic acid library to position and/or functionally couple selected molecules is refened to herein as a synthetic heteropolymer, even though the random sequence segment is not stπctly a defined sequence segment until the selected heteropolymer is characteπzed. The second defined sequence segment of a synthetic heteropolymer compnsing an aptamenc first defined sequence segment may be a conjugated defined sequence segment capable of hybndizing a selected nucleic acid sequence compnsing a pnmer or may alternatively be an unconjugated defined sequence segment capable of hybndizing a selected nucleic acid sequence compnsing a conjugated pnmer. However, a nucleic acid molecule compnsmg a randomized sequence and one or more fixed, unconjugated pnmer-annealing sequences is not a synthetic heteropolymer, nor is an aptamer compnsing one or more unconjugated pnmer-annealing sequences for unconjugated pnmers. So long as a synthetic heteropolymer compnses at least two defined sequence segments capable of specifically binding, hybndizing or positioning a selected nonoligonucleotide molecule or selected nucleic acid sequence, wherein at least one synthetic defined sequence segment is capable oi specifically binding a nonoligonucleotide molecule, there is no upper limit to the number of defined sequence segments per synthetic heteropolymer. Any nucleotide-based discrete structore that compnses a synthetic first defined sequence segment capable of specifically recogmzing a first (nonoligonucleotide) molecule and a second defined sequence segment capable of specifically recognizing a second (nucleotide or nonnucleotide) molecule is or compnses a synthetic heteropolymer, so long as the first and second molecules are different molecules and the second defined sequence segment is not an unconjugated pnmer-annealing sequence or a nbozyme. Two different aptamer molecules joined to one another either directly or indirectly via a linker (i.e., a nucleotide spacer, spacer molecule, ohgonucleotide linker or nonnucleotide linker) to form a discrete structore capable of specifically recogmzing two different nonoligonucleotide molecules is a synthetic heteropolymer, alternatively refened to herein as an aptamenc multimolecular complex. A discrete structore compnsing an aptamenc defined sequence segment attached indirectly via a linker to a second defined sequence segment is also a synthetic heteropolymer if the discrete structure is capable of specifically recogmzing a nonoligonucleotide first molecule and of hybndizing to an oligonucleotide second molecule compnsing a selected nucleic acid sequence. "Synthetic photosynthetic molecule" refers to artificial photosynthesis as known in the art and includes synthetic energy conversion systems that mimic the natural process of photosynthesis. The term "synthetic reaction center" means a molecule or group of molecules capable of existing in a light-induced, charge-separated state, thereby mimicking the function oi a natural photosynthetic reaction center. The term "synthetic receptor" means a "designer receptor," i.e., a naturally occurnng, recombinant, biological, biologically produced or synthetic nucleotide or nonnucleotide molecule or group of molecules compnsing a specific recogmtion partner selected from the group consisting of specific binding partners, hybndizable nucleic acid sequences, shape recognition partners, specifically attractive surfaces and specific recognition pairs, advantageously a mimetic specific recogmtion partner (i.e., a receptor mimetic) that mimics or approximates the binding specificity of a selected target or receptor (e.g., a therapeutic target) for its recognition partner (e.g., a drug, hormone or transmitter) or a selected receptor that specifically recogmzes a drug or a therapeutic receptor The term "system(s)" means a system that optionally or advantageously compnses paired systems. The term "target," when used in reference to a recogmtion element, shape-specific probe, multimolecular structore, multimolecular device or MOLECULAR MACHINE, means a selected target, aptamer target, therapeutic target, target molecule, selected molecule, target sequence, selected nucleic acid sequence or, in the case of a shape-specific probe, a specifically attractive surface feature. When used in reference to molecular delivery devices descnbed herein, the terms "target" and "target molecule" mean a selected target or any identified substance, structore, process, device or object capable of being acted upon by a selected molecule or selected nucleic acid sequence including, without limitation, selected molecules, structural shapes and surface features, selected nucleic acid sequences, therapeutic receptors, pathological, physiological and anatomical sites, disease markers, diagnostic analytes, cells, cell surface antigens, cytoplasmic, subcellular, genetic and genomic markers, biological recognition sites, environmental markers, pollutants, pests and pathogens, agπcultural products, strains, symbiotes, pests, pesticides, pathogens and contaminants, industnal feedstock, products, byproducts, wastes, process and quality control analytes, chemical weapons, biological weapons and selected sites, recogmtion elements and recogmzable features compnsing matenals, substrates, transducer surfaces, amphibious surfaces, specifically attractive surfaces, chemically bland surfaces, solid supports, arrays, biochips and micromimatunzed and nanofabncated devices. The terms "target sequence" and "targeted sequence" refer to selected targets compnsing selected nucleic acid sequences. The teπn "template" means a bivalent or multivalent nucleotide or nonnucleotide molecule or molecular scaffold capable of positioning at least TOO molecules, preferably a multivalent molecular structure compnsing a MOLECULAR MACHINE The terms "template-directed," "template-based" and "templating" refer either to a nucleotide-directed process or product or to specific attachment of one selected molecule or surface to another selected molecule or surface by means of a nucleotide-based or nonnucleotide template or molecular scaffold capable ot specifically recognizing at least one of the selected molecules or surfaces The term "tethered," when used in reference to a tethered recogmtion device or specific recogmtion pair, means that two members of a recognition pair compnsing a synthetic multimolecular structure remain connected to one another by covalent or pseudoinev ersible and preferably site-specific attachment to a common molecular scaffold or multimolecular structure, regardless of whether the recogmtion partners are directly attached to one another or not. For example, tethered members of a specific recogmtion pair covalenth or pseudoineversibly attached to a common molecular scaffold may be either specifically attached to one another (e.g., hybndized or specifically bound) or not specifically attached to one another (e.g., unhybndized, dissociated or unbound). The terms "tethered specific recognition device," "tethered recognition device," "tethered molecular recogmtion device," "tethered device" and "tethered specific recogmtion pair" refer to stimulus-responsive synthetic devices compnsing a molecular scaffold, optionally a s nthetic nucleotide or a nonnucleotide multimolecular structore, and at least two members of a specific binding pair or four members of two different specific recognition pairs, each member being covalently or pseudoirreversibly attached in a site-specific manner to the molecular scaffold. Each member of a specific recogmtion pair compnsmg a tethered recogmtion device is covalently or pseudoirreversibly tethered to its specific recognition partner by attachment to a common scaffold, so the specific recogmtion partners remain connected (i.e., indirectly attached) even when they are not specifically bound or hybndized to one another (i.e., not specifically and directly attached) Unlike pπor art tethered compositions, each tethered device of the instant invention is capable of existing in either of two functionally different states (e.g., "on" or "off") depending on whether a selected target is present. The instant tethered devices are therefore stimulus-responsive, i.e., specifically responsiv e to a selected target. For example, specific recognition of a selected target molecule by a tethered recognition device results in generation of a detectable signal or targeted deh ery of a payload molecule, e.g., an effector molecule or drug. Advantageously , the molecular scaffold to which members of a specific recogmtion pair are tethered may compnse a conjugated aptamer. In other words, an aptamenc multimolecular device having two members of a nonaptamenc specific recognition pair conjugated to an aptamenc molecular scaffold is an aptamenc tethered specific recognition dev ice. In this embodiment, at least one member of the aptamenc and/or nonaptamenc specific recogmtion pair further compnses an effector molecule, e.g., the member is detectably labeled or specifically attached to a releasable or activatable effector (e.g., a prodrug). The terms "tethered recogmtion device," "tethered recogmtion pair" and "tethered device" may also refer to stimulus-responsive devices that alternatively compnse two members of a catalytic recognition pair covalently or pseudoineversibly attached to a molecular scaffold The interaction between first and second molecules compnsing the catalytic recogmtion pair may be modulated by the binding or activity of a third molecule compnsing or capable of recogmzing a functional element of the tethered recognition dev ice The terms "therapeutic receptor," "target receptor" and "pathophysiological receptor," when used in reference to drug delivery methods and devices disclosed herein, mean nucleotide and nonnucleotide targets of drug, hormone and transmitter action, including selected molecules, selected nucleic acid sequences and structural shapes. The terms "therapeutic target," "pathophysiological target," "pathological target," and "disease target," refer to the physiological, pathological and anatomical sites of drug action and include therapeutic receptors, targeted molecules and receptors, target molecules and receptors, groups of target molecules or receptors, and cells or groups of cells compnsing target molecules or receptors. "Tight coupling" and "efficient coupling," when used in reference to the functional coupling of machine intelligence to a process, domain or system, means that data and/or information are effectively comprehended in a usefully timely manner Perfect effectiveness means comprehension of all information with absolute fidelity . Perfect timeliness means immediate or instantaneous. For any given application or process, "Tight" and "efficient" are relative terms, i.e., quantitative standards vary for different applications. For purposes disclosed herein, these terms refer to a degree or efficiency of functional coupling that is practically useful and sustainable, preferably increasing with time, i.e., growing more efficient and thus becoming more effective. Any degree of functional coupling may be useful. Absence of functional coupling means that two substances, processes, devices or systems function independently or autonomously, i.e., they are functionally uncoupled. Loose coupling means an intermediate or partial degree of cooperation between two substances, processes, devices or systems which may or may not be practically useful. Particularh useful loosely coupled substances, processes, dev ices and systems are those in which the degree of functional coupling increases with time, i.e., the substances, processes, devices or systems evolve toward tight and efficient functional coupling, thereby approaching perfect functional coupling. The terms "tight coupling" and "efficient coupling," when used in reference to the functionally coupled substances, processes, devices and systems, shall be inteφreted and understood by analogy to conesponding terms describing informational devices. Conversely, the term "functional coupling," when used in reference to informational devices, machine intelligence and library selection, is to be inteφreted and understood as a metaphor in respect of the functional coupling between molecules compnsing multimolecular devices. "Transduce" means to convert, transform, transfer, modify, send, receive or interconnect from one substance, process, state, form, unit or level of matter, information, order or energy to another or between two substances, processes, states, forms, units or levels of matter, information, order or energy, typically by means of a change in the relative energy state, velocity or position of two molecules or a molecule and its environment, particularly a change that occurs in response to a thermal gradient, electπcal, chemical or electromagnetic potential, mechanical force, specific stimulus or recogmtion event. The terms "transducer" and "transducer surface," when used in reference to an immobilized substance or specifically attractive surface, refer to surfaces, solid supports and devices capable of converting an output of a molecule, multimolecular structure or multimolecular device (e.g., matter, energy and/or heat) into a qualitatively or quantitatively different form, wherein the conversion produces useful work or a detectable signal. Functional coupling between a multimolecular device of the invention (e.g., a multimolecular transducer, multimolecular switch or multimolecular sensor) and a transducer surface can be accomplished, e.g., by the transfer of mass, energy, electrons or photons or by coupled chemical or enzymatic reactions that share a common intermediate, mediator or shuttle species The terms "transpose," "transposing" and "transposition," when used in reference to nucleotide library-mediated processes and products, refer to mapping, impnnting, transforming, expressing, reflecting, bouncing, passaging, passing, projecting, or converting a first property, shape, structure or activity compnsing a first molecule, mateπal, molecular medium, hbrary or selected population withm, through, on, off, or into a second molecule, mateπal, medium, population, library or region of diversity space Transposition may be used to create an impnnt, antnmpnnt, antiidiotype, idiotype or mimetic of a nucleotide or nonnucleotide target or an impnnt, replicate, mimetic or progeny thereof, e.g., any successive off spnng or descendant evolving from the parent molecule, segment, nucleotide, precursor, donor or target. In one mode of operation, the bivalent and multivalent recogmtion properties of synthetic heteropolvmers are transposed into nonnucleotide molecular media by dual impnnting, creating anti-antiidiotypes or idiotypic mimetics of synthetic heteropolvmers. The term "undiscoverable" means either already discovered or unknown and unknowable The term "unknowable," when used in reference to molecules, matter, data, information, energy, methods, pπnciples, processes, compositions or applications, means not kno n and not capable of being known or discovered. The terms "unknown" and "unknown information" refer to information that is not heretofore known, including information capable of becoming known (i.e., knowable and discoverable information) and information not capable of becoming known (i.e., unknowable information). The terms "willful" and "willfully" refer to human will, intent, design, or purpose. DESCRIPTION AND EXAMPLES This invention relates to methods and structures for coupling the activities of two or more molecules or groups of molecules, preferably molecules with defined activities, to perform functions dependent on the spatial proximity of constituent molecules. Whereas Cubicciotti, U.S. 5,656,739 discloses a method for specificalh and noncovalentl} assembling selected molecules into a single multimolecular structure through use of synthetic heteropolvmers or multivalent heteropolymenc hybnd structures compnsed of hybndizably linked svnthetic heteropolvmers, the instant invention further provides template-ordered multimolecular devices which are covalently or pseudoirreversibly stabilized. Also provided are nonnucleotide multimolecular devices compnsing impnnts and mimetics of synthetic heteropolvmers. Each synthetic heteropolymer disclosed herein compnses nucleotides having at least a first and a second defined sequence segment. One defined sequence segment of a synthetic heteropolymer or multivalent heteropolymenc hybnd structore is capable of specifically binding to a selected nonoligonucleotide molecule or group of molecules, preferably a receptor, ligand, structoral molecule or effector molecule, or specifically recognizing a surface feature of a specifically attractive surface. The other defined sequence segments are capable of either specifically binding to a different nonoligonucleotide molecule, group of molecules or selected nucleic acid sequence or of specifically recogmzing a surface feature of a specifically attractive surface or of hybndization or of participating by means of a conjugated molecule, optionally a conjugated nucleic acid molecule, in functional coupling to a selected nonoligonucleotide molecule or group of molecules specifically bound to a first defined sequence segment. The present invention teaches methods to engineer defined sequence segments into a sequence of nucleotides, modified nucleotides or nucleotide analogs that control the proximity of two or more selected molecules by the relative positions of defined sequence segments along the sequence and further provides covalently stabilized devices prepared from nucleotide-directed molecular assemblies. Also provided are nonnucleotide multimolecular devices compnsing multivalent impnnts and mimetics of nucleotide-based multimolecular devices Useful multimolecular devices of the invention include switches, sensors, transducers and drug delivery systems produced using both the covalent and noncovalent binding capabilities of nucleotide polymers, selected molecules and conjugates thereof, including, hybndization of complementary nucleotide sequences, aptamer recogmtion of nonnucleotide molecules, specific binding between ligands and receptors, specific binding between noncomplementary nucleic acid sequences, and even self-assembly of MOLECULAR MACHINES using nucleotide-based templates Nucleotides of the instant invention, particularly defined sequence segments, aptamers, specific binding pairs, shape recogmtion pairs and conjugates thereof, also combinations of defined sequence segments compnsing synthetic heteropolymers, and even combinations of multiple synthetic heteropolymers compnsing multivalent heteropolymenc hybnd structures, are sho n herein to prov ide control over the relative positions of specifically and co alently bound molecules The resulting switches, sensors, transducers and drug delivery devices function in a highly efficient manner due to the spatially ordered arrangement of molecules within multimolecular devices In a prefened aspect of the invention, multimolecular devices compnse at least t o different speαfic recogmtion pairs positioned by nucleotides in suitable spatial proximity to enable either functional coupling between the specific recogmtion pairs or, in the case of certain molecular delivery devices, concerted action of two or more selected molecules (e.g., drugs) at a selected target (e.g., a therapeutic target). The positiomng capability of defined sequence segments descnbed herein refers to functional coupling both between different molecules connected by nucleotides and between nucleotide-positioned molecules and selected targets The benefits of functional coupling between and among molecules compnsing and targeted by nucleotide-based multimolecular devices in many ways parallel the structural and functional efficiencies realized through biological evolution and self- organization. Nucleotide-based templates can be also be designed or selected to specifically recognize structoral molecules of surfaces, parts, products, articles of manufacture, containers, packaging and packing matenals for use as reversible and reusable adhesive coatings. Speαfic binding of a bivalent template to at least one of two surfaces allows the surfaces to be bonded, optionally reversibly and repetitively A first ligand, receptor or defined sequence segment of the bivalent template, optionally two or more hybπdized nucleotide sequences binds the first surface. A second ligand, receptor or defined sequence segment of the bivalent template binds the second surface. Reversible surface bonding is achieved by specific template binding to structoral molecules compnsing the surfaces, optionally aided by hybndization of two or more defined sequence segments. If the composition of the two surfaces is different (i.e., foil on leather or vinyl on cardboard), a bivalent adhesive applied to one surface onents in a sided and reproduαble manner Each member of a plurality of templates also onents in a sided and reproducible oπentation. Once a selected second surface is placed upon the template-modified first surface, the templates thus consort in bonding the surfaces A plurality ot weak-binding templates can effectively and reversibly bond the two surfaces due to their collective binding strength. Because the bound templates share a common bivalent specif lαty and are uniformly oπented, their collective binding strength can be specifically and efficiently reversed by a specific and convenient inten'ention, e.g., application ot a selected laser or electromagnetic frequency. If the composition of the two surfaces is the same (l e.. two flaps or panels of a cardboard box), the structure of the template is designed to prov ide specific, efficient and uniform binding to the surfaces. Collective binding is achiev ed, e.g., using dendnmenc or sphencal polymenc templates having surface-binding ligands uniformly attached in a site- directed manner Advantageously, linear polymers of defined length may be used, preferably with surface-binding ligands positionally controlled in both Cartesian and polar coordinates. Modified helical DNA is well suited of this application Alternativ ely, bivalent or multivalent DNA-hgand templates may be used as impnnt molecules A plastic adhesive capable of joining two surfaces in a specific and reversible manner can then be prepared in two sequential generations of cast-and-mold impnnting. Adhesive templates and adherent probes of the in ention can even be designed to specifically recognize a particular structural shape or surface feature (i.e., a shape, texture, contour or other localized property) on the structure or surface, e.g., for specific attachment of selected molecules to microminiatoπzed devices and/or nanofabncated features Shape- speαficity is distinct from ligand-receptor binding as known in the art. Shape-specific adhesive templates or adherent probes specifically recognize one surface ieature (e.g., an edge) without binding others (e.g., a face). Two surfaces having the same composition but a different surface teature, optionally male and female contours, can be aligned by a shape- specific bivalent template. Shape-speαtic recogmtion oi a first part, edge or face by a shape- specific template enables specific adhesion (bonding) to a second part, edge or surface, optionally also treated. Shape-specific adhesion between surfaces is advantageously reversible. Precise and specific feature-to-feature registration ot first and second surfaces and parts enables nanotabπ cation of hybnd devices with molecular-scale resolution. Multiply patterned surfaces may also be prepared b} selecting and specificalh attaching at least two, different shape recognition probes or templates to a surface, preferabh to each of two surfaces. Feature-specific attachment of bivalent templates to two different male features on a first surface corresponding to equiv alently spaced female features on a second surface enables precise and umque registration of the surfaces. Advantageously, bivalent nucleotide-based templates feature-specifically attached to the male surface may be hybπdized to complementary bivalent nucleotide-based templates feature- speαficalh attached to the iemale surface. The surfaces may be reversibh bonded and willfully separated. Alternatively, they may be covalenth and permanently attached, e.g., by photoactivated crosshnking Whereas molecular adhesives of the instant invention are used to specifically attach two surfaces, molecular adherents are used to attach a first selected molecule to a second selected molecule compnsing a surface. For example, a single nanofabncated surface ma} be functionahzed by template-directed and feature-specific attachment ot MOLECULAR MACHINES disclosed herein. For example, A selected molecule (e.g., a signal-generating molecule) or a multimolecular device (e.g., a fluorescence energ} transfer complex) may be site-specifically delivered, e.g., to a selected, speαficalh attractive surface feature (e.g., an edge, pit, vertex, directnx or nadir). Advantageously, nonselected surfaces or parts need not be modified, ev en if they hav e the same chemical composition as selected surface features Nonselected surfaces are not specificalh attractive and therefore not specificalh recogmzed Because shape recognition is specific for a surface feature and not its chemical identity, monolithic nanoscale features on micromachined surfaces can be specifically decorated with useful MOLECULAR MACHINES. Feature-specific deliver} of MOLECULAR MACHINES to nanofabncated shapes (e.g., diamondoid features of a carbon, silicon or gallium arsenide device) enables precise structoral and functional integration of orgamc and inorganic surfaces and device components. Alternati eh, optoelectromc MOLECULAR MACHINES patterned in a feature-directed manner to pits compnsing CD and DVD surfaces can be used as marking devices for antipiracy and anticounterfeiting purposes. Molecular adherents of the instant invention can be used not only to attach a first selected molecule (i.e., the delivered or targeted molecule) to a target surface, they can also be used to degrade, digest, detoxify or remove a second selected molecule (i.e., a selected target molecule) compnsing or attaching the target surface. For example, a molecular adherent designed to prevent or treat microbial corrosion of a nuclear reactor surface ma} compnse a first recogmtion element (i.e., a specific recogmtion site) that specificalh attaches to a molecule or surface feature compnsing the conoded surface (e.g., a biofilm-modified metal). A second recogmtion element of the molecular adherent, e.g., an antimicrobial enzyme or drug, may then kill and/or degrade the causativ e microbe. Alternativ ely , a surface active effector molecule (e.g., an oxidoreductase or electroactive catalyst) may directly modify the properties of the corroded surface. Related applications include, e.g., prevention, remediation, treatment or surface remo al of dental plaque, bactenal contamination, mold, mildew , dust, pollens, mites, allergens, toxins, rust, tarnish, oils, films, paints and coatings. The development of molecular adhesives and adherents is enabled by the ability to either 1) identify a selected molecule capable of specifically recogmzing the surface, either by specific binding, hybndization to a nucleotide-modified surface (i.e., in the case of molecular adhesives). structural shape recogmtion or, alternatively, 2) selection ot a surface feature capable of recognizing an identified molecule. Selection ot specific recogmtion molecules or surfaces (i.e., structural shapes, surface features or selected molecules compnsing a surface) may be accomplished by identifying a heretofore known selected molecule (e.g., a known ligand, receptor, effector molecule or structural molecule) having a desirable property or activity, preferably using an informational devιce(s) compnsing a paired molecular search engιne(s). A first molecular search engine explores a first multidimensional, evolving knowledge base encompassing heretofore known (i.e., heretofore identified) molecules and their properties, activ lties, interactions, sourcing and production/processing data. A second structural shape search engine explores a multidimensional, evolving knowledge base encompassing heretofore known structures and surfaces (e.g., substrates and/or feedstock matenals compnsmg potentially useful structural shapes and surface features), including heretofore known properties, activities, interactions, sourcing, production and processing considerations. The informational system (paired search engines) is functionally coupled in a closed-loop, divergent (i.e., positive) feedback control system, wherein the learning of one system at one and the same time advances and is advanced by the expanded comprehension of the other. In addition, the molecular knowledge base search engine (i.e., molecular knowledge base) is functionally coupled to an information source, preferably a willful datastream compnsing not only heretofore available, but also emerging molecule and structures/surfaces data. In this way, the identities, properties, activities, interactions and use-considerations of heretofore known molecules and matenals is conelated withm an evolving informational system, preferably compnsing, attaching to or capable of attaching to an expert system, intelligent machine and/or willful director. Similarly, novel catalytic properties may be introduced to a surface by either 1) attaching a catalytic selected molecule or nucleic acid sequence to the surface using a bivalent or multivalent template or, alternatively , 2) selecting a surface library for a surface feature having a selected catalytic recognition property . Plastic segments of the instant invention denving from functionally coupled nucleotide-nonnucleotide hbranes enable transposition of the binding properties of structural shapes (i.e.. surface features) into molecular and catalytic recognition partners and vice versa. A surface feature previously confined to the diversity domain limited by chemical blandness can now be transposed into molecular structure-activity-shape space by impnnting to a paired hbrary. Conversely, a structural shapes can be endowed or adorned with molecular diversity by at least two heretofore unknown methods. First, a diverse structural space library (i.e., surface library or mateπal library) can be created by random, randomized, or rational, preferably combinatonal nanofabπcation techniques (e.g., emerging MEMS, NEMS, lithographic, ion beam and electrospray techmques). A selected specific recognition partner (e.g., a plastic segment), optionally a selected library of selected plastic segments) can be displayed on a chemically bland substrate (e.g., freshly cleaved mica) in a structurally oπented manner, e.g., by site-directed covalent attachment. Alternatively, using a chemically bland surface compnsing a selected or designed surface feature (e.g., nanometer-scale concave pits or conical tips compnsing umquely shaped nadirs, vertices and directncies), specific attachment can be achieved using molecular adherents compnsing bivalent plastic templates disclosed herein, the plastic templates having a binding domain (e.g., defined sequence segment impnnt) capable of specifically recogmzing the selected surface feature. The second binding domain of the plastic segment is then displayed in a controlled, preiened and uniform onentation. Whether by site-directed covalent attachment of a plastic segment or feature-specific recognition by a bivalent template, the result is a modified surface displaying a selected molecular shape or an assortment or array, random or ordered in the two dimensions compnsing a planar surface, of selected segments or paired segment templates compnsing a selected library. This shape- modified surface (i.e., surface template or specifically grafted surface) can then be scanned by single-molecule detection techniques descnbed herein, preferably SPM, more preferabh AFM, advantageously multiplexed AFM compnsing multiple cantilevered probe tips operating in parallel. Information from this surface template is then used as a knowledge base defining three-dimensional shape(s) of displayed segment(s) to be conelated with similarly determined surface features compnsing the surface library. In this way, selected surface featores can be identified which mimic the recogmtion properties of a molecular shape. The selected surface features can then be transposed through a nucleotide- nonnucleotide library into a newly selected molecular medium (i.e., a prefened and/or compositionallv diverse molecular matnx) by paired impnnting, e.g., a two-step impnnting process generating firstly antiidiotvpic and secondly idiotypic impnnts of the selected surface feature. Advantageously, the newly selected (i.e., evolved) molecular medium compnses a suitably compact, compressed, ngid and/or defined structore and shape to enable precise and informative three-dimensional AFM imaging of surface-displayed template featores. It will be apparent to the skilled artisan that an analogous method can be applied to biological surface-displayed molecular and structoral shapes as well (e.g., phage displayed peptides, complement determining antigens, Fc receptors, drug receptors, hormone receptors and the like, optionally displayed in self -assembling films, surface coatings, layers or membranes). Second, bivalent plastic templates can be used to modify surfaces by adherence without scanning and transposing of a desired molecular shape into the surface mateπal itself. For biomedical devices such as heaπng aids compnsing microcantilever-bound MOLECULAR MACHINES functionally coupled to cochlear cells of the inner ear, biological and biomimetic matenals are prefened. Microcantilevers may have dimensions on the order of typical AFM probes (e.g., about 100-200 microns long x 20-40 microns wide x 0.3-3.0 microns thick). Alternatively, further miniatuπzation to micron and even submicron dimensions (e.g., 1.0 x 0.3 x 0.1 microns) enables honing of device responsiveness (i.e., sensitivity) to the attogram scale. Biomimetic matenals are optionally selected by impnnting defined sequence segments compnsing nucleotides into plastic segments, preferably by transposing a nonbiomimetic but othenvise attractive precursor through a nucleotide library followed by selection of a plastic segment or template from a second, biomimetic molecular medium (vide infra). For microelectronic applications, e.g., attractive matenals include metals, semiconductors, synthetic (organic) metals and synthetic semiconductors, including 5 insulators and Mott insulators and further compnsing dopants. For example, a bivalent plastic template is impnnted from a synthetic heteropolymer into a semi-πgid polymeπc matnx, e.g., polyacrylate, by paired library transposition or by molecular impnnting methods known in the art (e.g., Shea et al. (1993) J. Am. Chem. Soc. 775:3368-3369; Ramstrom et al.(1993) J. Org. Chem. 58:7562-7564; Vlatakis et al.( 1993) Nature 367:645- 10 647). This bivalent impnnt template is then transposed by a second impnnting step into a second molecular medium, preferably a relatively compressed and ordered rigid polymenc structore having conductive, semiconductive or insulating properties compatible, advantageously synergistic, with the structure and function of the microelectronic de ice. For example, to functionalize a field effect transistor e.g., a 0.1 micron MOSFET switch, a 15 plastic molecular adherent is impnnted or transposed from a bivalent aptamenc or heteropolymenc template into a conesponding antiidiotype plastic template compnsing a first binding domain specific for the conjunction between the planar surface sunounding the FET device and the channel wall (i.e., ledge junction). The second domain of the plastic template may be a binding domain, a catalytic domain or an alternative effector (e.g., a redox, 20 photonic, or electroluminescent domain). In this way, new functionalities heretofore presumed to occur only in the realm of molecular shape space (i.e., molecular and catalytic recogmtion as distinct from specific surface attractivity) are introduced to chemically bland surfaces. Template-directed attachment of a heat sink and/or thermally tnggered switch may enable, e.g., development oi a molecular coolants or surge protector to prevent overheating 25 of densely packed pπnted circuits (i.e., feature sizes in the 1-100 nm range). Alternatively, in situ amplification of a negatively charged nucleotide polymer may be used to generate an electrochemical potential or electromotive force (i.e., a molecular battery), e.g., by polymer replication-induced partitioning of charged monomeπc nucleotides across a semipermeable membrane, channel, matnx or gate to which the replicated polymer is impermeable. 30 The melding of surface space and recogmtion space has important commerαal implications. For example, seamless integration of biomimetic and semiconductor functionalities into hybnd devices and systems can now be achieved. This hybndization provides the art with a path to biosensors, biochips and molecular anays capitalizing on the most useful and powerful attributes of matenals and molecules heretofore refractory to 35 sustained and meaningful camaradene. While efforts to achieve intimate contact and functional coupling between biologicals and inorganic substrates have long been in development (e.g., biosensors, biochips, heanng aids, implantable drug delivery systems), achieving stable, tightly coupled integration has been impaired by the diffeπng needs and interests of participating compositions. For example, biologicals tend to prefer wet, salt} , proteinaceous solutions. Semiconductors, metal, and insulators, by contrast, are favor dry, clean, crystalline and particle-free. Semiconductors, FETS and switches are fabπcated from bulk matenals with 0.1 to 1.0 micron feature sizes, evolving toward and below the 100 nm scale. Biological and biomimetic recogmtion reagents are molecules, supramolecular assemblies at best, having molecular sizes up to about the 10 nm scale. Structural shape (i.e., surface feature) selection from diversely modified surfaces, as descnbed herein, and nucleotide-hbrary mediated diversification and impnnting of identified surface features will bndge this gap between the 0.01-10 nm molecular playground and the 100-1000 nm world. The instant invention also enables innovative functionalization of emerging diamondoid structures and shapes compnsing fullerenes, buckyballs and related carbon- based nanostructures, e.g., carbon nanotubes, nanorods, and the like, doubtless to be followed b} novel silicon and gallium arsenide devices and heretoiore unknown ceramics. Plastic segments and templates disclosed herein can be used as adherents to decorate such diamondoid structures with specific recognition and catalytic recogmtion properties or to enhance connectivity, e.g., to molecular wires and molecular switches. Alternativ eh , bivalent plastic templates can be used as adhesives to integrate carbon nanotubes, nanorods, nanolevers and other emerging nanostructures with emerging submicron-scale photolithographic features. Alternativeh, nucleoplastic templates compnsing nucleotides, optionally encapsulated in glassy matnces can be used to perform on-board processes heretofore known only to nucleotides, e.g., programmable self- assembly, replication, amplification and combinatonal mutation. Single-molecule detection, isolation, amplification and/or sequencing can be applied not only to aptamer screemng, but to identification and charactenzation ot other synthetic nucleotides having commercially useful properties or potentially useful activities that can be adapted or evolved in vitro tor commercial use, e.g., πbozymes, catalytic DNA, and hbran -generated nucleotides having a specific binding or surface feature binding property or catalytic activity (i.e., catalytic recognition). In a prefened aspect of the invention, a library of random-sequence nucleotides, each random-sequence nucleotide compnsing or attaching to a first selected molecule (preferably a first molecular effector or selected nucleic acid sequence hav ing a first selected activity) is screened and selected for the ability to recognize a target compnsing a second selected molecule (preferably a second molecular effector capable of cooperating with the first, preattached selected molecule). Random-sequence nucleotides capable of recognizing the second selected molecule (e.g., effector molecule) or nucleic acid sequence (e.g., conjugate, nbozyme, catalytic DNA, recogmtion site) are then selected by single-molecule detection of functionally coupled nucleotide-target molecules. Unlike single chromosome imaging and excision as known in the art, the instant methods provide a means for harvesting potentially v aluable synthetic nucleotides from synthetic hbranes based on functional activities, e.g., specific binding, specific attractivity and catalytic recognition. Also unlike heretofore known scanning probe chromosomal dissection efforts, the instant invention discloses not only single-molecule amplification followed by large-scale sequencing, but also a single-molecule sequenαng modality. The instant methods are advantageously applied to single-stranded as well as double-stranded synthetic nucleotides, including πbonucleotides, deoxyπbonucleotides, hybnds and chimenc sequences, preferably nucleotides having as few as one two bases per sequence. Also disclosed herein is the use of single-molecule detection and sequenαng to deconvolute nucleotide-encoded chemical hbranes, particularly modified nucleotide hbranes compnsing nucleotide ligands, nucleotide receptors and nucleotide catalysts. Single-molecule detection, amplification and sequencing methods disclosed herein are not drawn to analysis, mapping or sequencing of chromosomal DNA or genomic nucleic acids or to natural replication, transcnption or translation of biological nucleic acids to yield natural, recombinant or transgenic proteins. These and other applications of nucleic acids, nucleic acid analysis, single-molecule imaging and single-molecule sequencing are known in the art and outside the scope ot this invention. However, as w ill be apparent to the skilled artisan on reading the instant disclosure, MOLECULAR MACHINES designed and selected using single-molecule detection methods provide highly sensitive, specific and well-defined multimolecular compositions capable of molecular counting, DNA diagnostics, pseudoimmunodiagnostics, clinical chemistry and high- throughput screening (e.g., for drug discovery), all with the potential to achieve single-molecule detection, charactenzation, diagnostics and momtonng. These and other single-molecule uses of MOLECULAR MACHINES, including the analysis, mapping and sequencing of genomic, microbial and plasmid nucleic acids, are fully within the purview of this inv ention. Mapping hbranes are preferably diverse hbranes of selected recognition partners, preferably nucleotides selected trom a diverse plurality of nucleotide hbranes, used to transpose the recogmtion properties of a selected population of selected nonoligonucleotide molecules into a selected population of replicatable nucleotides which can be sequenced and archived. Mapping hbranes may be used to create an antiidiotvpic or idiotypic image of a selected population of selected molecules through one or more impnnting steps. An antiidiotypic impnnt may be obtained in a single step to or from a nucleotide library. For example, a template may be impnnted in a single step to αeate an antiidiotype which is idiotypic to one or more selected molecules capable of recogmzing the parent template. Alternatively, a nonnucleotide receptor may be impnnted in a single step to create an antiidiotypic ligand. In a second impnnting step, the antiidiotypic ligand may be impnnted using a nucleotide hbrary to create a nucleotide idiotype of the parent receptor. The corresponding nucleotide library can be 1) sequenced with single-molecule resolution, 2) replicated with approximately perfect fidelity, 3) digitally archived in the form of sequence information compnsing a searchable knowledge base of an informational system (e.g., search engine), 4) archived as matter, e.g., replicated clones of the parent mapping library, 5) amplified with vanable fidelity to generate diverse brethren hbranes useful in searching functionally defined regions of molecular diversity space, 6) transposed by impnnting into alternativ e molecular media expressing different structural and functional dimensions of the parent mapping library, and 7), functionally characteπzed by single-molecule detection methods as disclosed herein, e.g., detection of specific binding proclivities to selected molecules using, e.g., AFM and/or optical scanning/microscopy. The specific binding procli ity of a library is preferably determined by massively parallel scanning ot a selected array of selected molecules by optically guided, multiplexed SPM techniques presently becoming known to the art. These individual and collective embodiments of transposition, enable the exploration, expression, amplification, displa}, archiving, permutation and combinatonal conelation a selected population of selected molecules first in molecular space and second in functionally coupled informational space. Impnnt library means a mixture of molecules prospectively compnsing a recogmtion partner for an identified target. The commercial potential of nucleotide-directed mapping hbranes is substantial Nucleotide-directed transposition of provides a general method for characteπzing, cloning and archiving representations of any selected population of selected molecules both in molecular space and in information space. For example, a selected population compnsing B cell, T cell or macrophage-engulfed antigens or antibodies; a selected population compnsing lymphocytic leukemia-specific antigens or cell surface antigens compnsing a fractionated tumor homogenate; a selected population of molecules capable of binding a selected surface; a selected population of molecules capable of catalyzing a selected chemical reaction; a selected population of molecules compnsing a selected hazardous substance or spill; a selected population of molecules compnsing the set of willfully accessible DNA lntercalators: a selected population of surface features compnsing the surface of a scar; a selected population of molecules capable of recogmzing smoke particles; a selected population of molecules capable of binding a selected microbe; a selected population of molecules capable of binding a selected population of selected microbes; a selected population of molecules capable of recogmzing serotonergic or β-adrenergic or dopaminergic receptors; a selected population of molecules capable of recognizing avidin or cancanavalin A or protein A or protein G or the Fc region of IgG; and so forth. Any of these selected populations of selected molecules can be transposed into nucleotide space, characteπzed, digitally coded, archived, cloned, amplified w ith impunity or infidelity and comprehended in information space. Products may further be mapped into a selected nonnucleotide medium which may represent a similar or entirely different region of molecular diversity space from the parent, nucleotide-mapped, selected population of molecules. Also disclosed herein is the ability to map molecular space (i.e., recognition space) into surface space (i.e., surface feature or matenals space). In fact, the ability to transpose surface features (e.g., scars, MOSFET channel junctions) into molecular shape space and vice versa, enables the mapping of any knowable population compnsing surface features or selected molecules into nucleotide space. The ability to map nucleotide space into a second molecular medium enables the recogmtion properties ot the parent population of selected molecules to be recast into a second molecular medium having different chemical and physical properties from the parent population. Nucleotide-mediated digital encoding and deconvolution oi the immune repertoire tor real time momtonng of health status is one particularh attractive application of the diversity that can be achieved with the paired nucleotide-nonnucleotide diversity generator disclosed herein. Questions and skepticism w ill anse regarding the potential of a nucleotide library to achieve the diversity required to map a system as complex, e g., as the human immune s}stem or even a subset thereof, e.g., all CD antigens on a particular subset of T cells or all IgGs having a selected class specificity (e.g., for gram negative bacteπa) These concerns are valid, in view ot the molecular and informational complexity of these mapping functions However, a divergent molecular divers generator ev olving toward infinite diversity can achieve adequate di ersity to comprehend (i.e., map) an} fimte population. A selected population of selected molecules is a finite set. Also, willful selection of a selected population of selected molecules means that the diversity of the selected population can be reduced, e.g., by tightening the selection cntena, fractionating cells or antibodies, isolating or punfying molecules by willful selection. Thus, a selected population of selected molecules, no matter how diverse the parent source (e.g., the set of all human immunoglobulins), is a convergent set. Diversity can be controlled, reduced to whatever degree necessary or practical. A fimte and potentially convergent selected population of selected molecules is mtnnsically within the mapping pun lew of a higher order hbrary of hbranes coupled to an intelligent informational system, e.g., a divergent, multidimensional diversity generator compnsing paired nucleotide-nonnucleotide hbranes, optionalh hbranes of paired nucleotide hbranes projected in molecular shape space. Selection and evolution of a mapping hbrary requires highh efficient means oi explonng diverse hbranes, preferably paired nucleotide-nonnucleotide hbranes and more preferably hbranes of paired hbranes. Selection is preferably achieved in a combinatonal manner, e.g., using selected populations of selected molecules (i.e., selected targets) and paired hbrary members (e.g., nucleic acids) conjugated to different signal-generating species, e.g., fluorescent particles diffenng in size, color and/or spectral properties. Advantageously, the paired library compnses a random-sequence nucleic aαd library, wherein member nucleic acids each compnse fixed-position or fixed-sequence nucleotides conjugated to a second and optionally a third, fourth and N m different signal-generation species, each expressing a different signal (e.g., color, fluorescence emission, enzyme activity, luminescence). Preselection or counterselection against structurally conserved epitopes is important in selecting hbranes for new recognition elements. Evolution of maximally informative mapping hbranes requires muting, filtenng or subtraction of redundant or uninformative specificities, e.g., epitopes compnsing immunoglobulin hinge and disulfide bndge regions. Capitalizing on both the plasticity and adherent properties of nucleoplastic templates, attractiv e applications include cosmetics and tissue repair. Examples include long- lasting and willfully removable cosmetics (vide infra) and mapping the shape space of a scar. By charactenzmg the surface attractivity and recogmtion properties of a healed, cosmetically imperfect facial scar, for example, biocompatible molecular adherents can be used to replace, enhance or supplement plastic surgery . A first machine-coupled paired nucleotide library senes as molecular diversity generator to produce a first set of hbranes willfully and intelligently designed to map the molecular and structural shape contours of the scar. A second machine-coupled paired library generator expresses and explores structure- activity-shape space for suitable biocompatible structural and effector molecules (e.g., mimetics of epithelium, keratin, collagen, elastic and/or contractile proteins, pigments). Template-directed molecular assemblies with affinities for the scar surface are then coselected in proximity space by a willfully directed, machine-coupled consorting system. The template-ordered molecules or assemblies are stabilized by irradiation or site-directed heterobifunctional conjugation. The stabilized conjugate or assembly is then optionally transposed through a paired nucleotide-nonnucleotide library into a second molecular medium (e.g., into a collagenous medium by antiidiotypic and anti -antiidiotypic impnnting steps). The final product, optionally evolved through multiple automated cycles, is a patient- specific, customized, biocompatible adherent that coats and smoothes the fibrotic surface of a scarred wound. A similar selection process can be applied the design and evolution of molecular adherents for a vanety of dermatologic and cosmetic applications, including smoothing, filling, plasticizing and colonng wπnkles, birth marks, acne-induced pock marks, pitting, dermabrasions and the like. Molecular adherents can also be formulated as topical smaRTdrugs compnsing targeted and/or tnggered release prodrug complexes that dissociate on binding of an allostenc recognition site to a selected therapeutic target (e.g., for treatment of psonasis, dermatitis, melanoma, impetigo, urticana and the like) The instant mapping hbranes and methods for mapping surface features into molecular shape space thus enable the transformation of recogmtion properties or surface features of a first mateπal or molecular medium into a second mateπal or molecular medium. This nucleotide-mediated molecular transposition process (i.e., transformation through nucleotide space) enables the properties of ordinary molecules to be represented, archived, amplified, and modulated in nucleotide space. Retneval may then be achieved in a second or third or fourth molecular medium, advantageously a molecular medium selected on structorofunctional grounds by an intelligent informational system, preferabh a functionally coupled network compnsing infoπnation source(s), knowledge base(s), hypothesis- generating and hypothesis-testing search engines as descnbed elsewhere in the instant disclosure. Nucleotide-directed transformation enables a selected stenle molecule or population of molecules to proliferate in molecular diversity space and thereby populate diversity space through faithful mapping (i.e., replication) and unfaithful replication (e.g., dnft, mutation or directed evolution via biased amplification) mediated by nucleotides, preferably paired nucleotide hbranes compnsing an automated, willfully directed process. Advantageously, transformation is achieved from a first selected molecule(s) to a second, improved selected molecule(s) by passing (i.e., transposing) the first selected molecule(s) through a nucleotide library. In this way, a first selected population of selected molecules, optionally a single selected molecule, can be mapped into nucleotide space, transposed into an alternative molecular medium or mateπal which can be retneved and archived in nucleotide space, and, as desired reflected into and expressed in still new and different matenals and media. Nucleotide mapping hbranes of the instant invention are s pnsingly useful, particularly iunctionally coupled paired hbranes compnsing at least a library of first nucleotide hbranes capable of representing a nonnucleotide library in nucleotide library space. This transposition of nonnucleotide molecules, preferably selected populations of selected molecules, enables the transformation of a heretofore stenle molecule or population of molecules into a replicatable, amphfiable, divergent molecular medium. Vaπous terms are used herein metaphoπcally to descnbe nucleotide hbrary- mediated transposition. For example, the diversity of a first selected molecular medium confined to a particular region of diversity space (e.g., decapeptides or octapeptides or Arg- Gly-Asp-Ser conformers) may be expanded, enhanced, mutated, transformed, or transposed by bouncing the molecule(s) off a nucleotide library or reflecting a first library off a nucleotide library or passaging or passing a first molecule through nucleotide hbrary or projecting or imaging a molecule or library in diversity space. These metaphors represent the inventor's attempt to articulate through visually tractable images a toolkit of methods and compositions that relate to N-dimensional space. These methods and compositions are best expressed in mathematical language(s) in which the instant inventor is not well versed. An important aspect of instant invention is to provide a paired library compnsing a nucleotide library and a nonnucleotide library (hereinafter nucleotide-nonnucleotide or paired nucleotide hbranes) capable of functiomng as a fertile molecular diversity generator, i.e., an automated process compnsing paired nucleotide hbranes capable of explonng diversity space on an application-specific basis through functional coupling with a diversity space search engine that is in turn functionally coupled to an information source (e.g., willfully acquired data, information or knowledge). Another important aspect is the mcoφoration of a molecular diversity generator- search engine pair within a multicomponent system designed to create, assemble, impnnt, transform and evolve useful molecules compnsing multimolecular assemblies, preferably either 1) self-rephcating, self-assembling nucleotide-based MOLECULAR MACHINES or 2) application-specific, plastic-casted impnnts compnsing multimolecular machines for industnal use. Components compnsmg the system include, for example, a molecular diversity generator (i.e., an evolution station with vanable fidelity amplifier); a sorting station (i.e., hbrary screemng and selection of selectable molecules), a consorting station (i.e., a molecular proximity optimization or functional coupling station); a templating station (i.e., preparation of nucleotide and nonnucleotide templates), a first template-directed assembh station (i.e., self-assembly of nucleotide-based multimolecular devices and MOLECULAR MACHINES), a conjugation station (I e , for covalent conjugation ot a pair or group of template positioned molecules or for covalent stabilization of MOLECULAR MACHINES), a casting or impnnting station (i.e., for transposing templates and selected molecules into alternative molecular media); a second template-directed assembly station (i.e., self-assembly of MOLECULAR MACHINES compnsing plastic templates and/or transposed selected molecules); a pπnting station (i.e., for plastic template-directed casting and molding oi impnnts and antnmpnnts). The precursors and products of each station (e.g., a template, selected molecule or assembled MOLECULAR MACHINE) may advantageously be recycled through the molecular div ersity generator in successive automatable rounds of paired nucleotide library -directed molecular evolution. Products of the system are 1) covalent conjugates of template-positioned, iunctionally coupled selected molecules, 2) self-assembling, advantageously self-rephcating nucleotide-based MOLECULAR MACHINES, optionally covalently stabilized, and 3) self-assembling nonnucleotide MOLECULAR MACHINES, optionally covalently stabilized. Selected molecules compnsmg conjugates and MOLECULAR MACHINES may be heretofore known molecules, or they may be identified and or evolved by the molecular diversity generator Synthetic heteropolymers disclosed by Cubicciotti. U S. 5,656,739 compnse a single-stranded nucleic acid molecule having at least a first and a second defined sequence segment, wherein the first defined sequence segment is capable of specifically and noncovalently binding to a first nonoligonucleotide molecule having a selected activity and the second defined sequence segment is capable of specifically and noncovalently binding to a second, different nonoligonucleotide molecule having a selected activity, wherein said first and second defined sequence segments are not known to be biological recognition sites for said first and second nonoligonucleotide molecules. Synthetic heteropolymers of the instant invention differ from the synthetic heteropolymers disclosed by Cubicciotti, U.S. 5,656,739 in several respects, most importantly in compnsing defined sequence segments capable oi covalently binding to selected nonoligonucleotide molecules and groups of molecules as well as specifically and noncovalently binding. Nucleotide sequences compnsing synthetic heteropolymers may be produced, detected and/or characteπzed through use of amplification systems well known in the art, including, but not limited to, polymerase chain reaction (PCR), ligase chain reaction (LCR), Q-beta rephcase, self-sustained replication (3SR), transcnption- based amplification system (TAS), repair chain reaction (RCR), cycling probe reaction (CPR), nbonuclease H or reAMP methods. For amplification, defined sequence segments or selected nucleic acid sequences preferably compnse or adjoin at least one pnmer annealing sequence (e.g , for 3SR amplification and circular nucleotides) and optionally at least two pnmer-annealing sequences (e.g , for PCR amplification of nucleotides having at least two termini) However, degenerate ohgonucleotide pπming may also be used to amplify a nucleic acid molecule of unknown sequence or a member of a mixture or library compnsing nucleic acids having unknown or randomized sequences In a prefened aspect of the instant invention, synthetic heteropolymers and methods of making, using, detecting or charactenzing heteropolymenc discrete structures descnbed herein compnse not only defined sequence segments, but also nucleotide recognition sites, e g , promoter and pnmer annealing sequences, and complementan sequences required or formed dunng amplification reactions A selected molecule or selected nucleic acid sequence specificalh bound or hybndized to a synthetic heteropolymer may be detected with high sensitivity b} amplifying the synthetic heteropolymer or any sequence compnsing the synthetic heteropolymer, preferably a defined sequence segment, provided specificalh bound or hybndized s}nthetιc heteropolymers can be distinguished from their unbound counteφarts, e.g , b} physical separation or homogeneous detection means. Synthetic heteropolymers descnbed herein and discrete structures compnsmg two or more synthetic heteropolymers are capable of noncovalently binding selected molecules or nucleic aαd sequences through speαfic binding or h} bndization at defined sequence segments In addition, one or more molecules or nucleic acid sequences, preferably selected molecules or selected nucleic acid sequences, ma} be covalenth attached to one or more nucleotides or defined sequence segments of a s}nthetιc heteropoh mer or multivalent heteropohmenc hybnd structure, provided the ability of at least one defined sequence segment of a s}nthetιc heteropolvmer to specificalh bind a nonoligonucleotide molecule is contened not b} the conjugated molecule itself, but b} the svnthetic heteropolymer or the three-dimensional structure of the conjugated synthetic heteropoh mer The specific binding property of a defined sequence segment of a synthetic heteropolymer is a property' of the defined sequence segment itself, optionally conjugated to another molecule or nucleic acid sequence, and is not intnnsic to the molecule or nucleic acid to which it may be conjugated. In other words, the ability of a defined sequence segment of a synthetic heteropolymer to speαfically bind a nonoligonucleotide molecule is a property of the defined sequence segment, optionalh including modified, deπvatized or conjugated nucleotides, and cannot be introduced simply by conjugating a ligand or a receptor to the synthetic heteropolymer or its constituent nucleotides. The synthetic heteropolymers of the instant invention are not deπved, selected or copied from wild-type biological nucleic acid molecules, sequences or groups of contiguous sequences, nor are they denved, isolated, selected or copied from heretofore known mutants, genetic vaπants or nucleic acid molecules or sequences therefrom. At least one defined sequence segment of each synthetic heteropolymer or multivalent heteropolymenc hybnd structure of the instant invention is not only capable of specifically binding a nonoligonucleotide molecule, but is also synthetic. When used to descnbe a defined sequence segment, synthetic means nonnaturally occurnng, i.e., the defined sequence segment is not heretofore known to occur in nature (sans human biotechnologic intenention) and is not heretoiore known to be a biological recogmtion site. Biological recogmtion site means a first biological molecule or nucleic acid sequence that is heretofore known to specifically bind or recognize a second biological molecule or nucleic acid sequence. Unless otherwise specified, artificial and synthetic refer to willful products of human technology. Native, in nature, natural, naturally occurnng, biological and organism, by contrast, refer to spontaneously occurnng substances or beings that are not willful products of human-directed recombinant or transgenic technologies. In the case of hybnd plants and animals that have been identified and/or perpetuated by cross-breeding, selective breeding, cross-pollination, stem or limb grafting and the like, native, in natore, natural, naturally occurnng, biological and organism mean only heretofore known strains. Where the distinction between natural and synthetic is ambiguous, a heretofore known substance, being or strain shall be considered natural for purposes of this disclosure, and a heretofore unknown substance, being or strain shall be considered synthetic. A selected molecule or nucleic acid sequence which is specifically and noncovalently bound or hybndized to a defined sequence segment of a synthetic heteropolymer can subsequently be permanently affixed to the synthetic heteropolymer by covalent attachment using bifunctional or multifunctional crosshnking reagents well known in the art (e.g., Wong, S.S. (1991) Chemistry of Protein Conjugation and Crosshnking, CRC Press, Boca Raton). Alternatively, crosshnking reagents reactive toward functional groups present on selected molecules and not present on synthetic heteropolymer nucleotides can be used with appropnate spacer arms to selectively and covalently attach molecules specificalh bound to proximally spaced defined sequence segments without chemically modifying the synthetic heteropolymer. In this way, synthetic heteropolymers can be used as templates to position molecules for reproducible and regiospecific attachment to one another. Selective modification and conjugation of selected molecules and positioning templates can also be achieved enzymatically, e.g., using well known biosynthetic enzymes, hgases, and the like. It will therefore be apparent to one of skill in the art that a defined sequence segment of a synthetic heteropolymer which is capable of specifically and noncovalently binding a selected molecule can also be used as a site of covalent attachment for the same selected molecule. Alternatively, selected molecules that are specifically and noncovalently bound to defined sequence segments of a synthetic heteropolymer can subsequently be covalently attached to one another. In a preferred aspect of the invention, bifunctional s}nthetic heteropolymers are used as templates to position selected molecules for covalent conjugation, optionally by regiospecific chemical modification and crosshnking techniques Template-directed covalent conjugation of selected molecules, preferably site-specific conjugation of functionally coupled effector molecules, enables efficient transfer of energy, electrons and photons between donor and acceptor species, advantageously including resonance energy transfer, fluorescence energy transfer and direct electromc coupling. In another prefened embodiment, covalent crosshnkers, preferably heterobifuncύonal crosshnking reagents, are used to stabilize multimolecular devices by chemically attaching specifically bound ligands, receptors, structoral molecules and effector molecules to nucleotides compnsing defined sequence segments, preferably by site-directed chemical modification. In still another preferred embodiment, selected molecules positioned by specific binding to a nucleotide template and optionally cov alently attached either to the template or to one another are used as pnnt molecules (i.e., guests) for preparation of nonnucleotide templates (i.e., hosts) capable of specifically binding and assembling the guests, e.g., using molecular impnnting methods known in art (e.g., Vlatakis et al. (1993) Nature 367:645-647, Shea et al. (1993) J. Am. Chem. Soc. 775:3368-3369, Ramstrom et al. (1993) 7. Org. Chem. 58:7562-7564). In this manner, the positioning capability of nucleotide-based templates descnbed herein can be transposed into nonnucleotide matenals (e.g., industnal polymers and plastics) with particular properties (e.g., thermal, optical, chemical and structural properties, availability, quality, reliability and cost) selected for compatibility with different commercial and industnal applications tor which nucleotide polymers may not be ideally suited. In another prefened embodiment, hbranes of nucleic acid hbranes, preferably hbranes of hbranes compnsing nucleic acid libraries, are screened and selected to identify, assemble (i.e., collect) and evolve a mapping library from impnnt hbranes of nucleotides that specifically recogmze members ot a selected population of selected nonnucleotide molecules. The evolved library compnses a diverse plurality of nucleic acids selected to map, transpose and/or image (i.e., impnnt) the recognition properties ot the selected population ot selected nonnucleotide molecules into a corresponding mapping librar . Advantageously , the diverse mapping library compnses nucleic acids which, unlike the selected population of selected nonnucleotide molecules, can be amplified, sequenced, quantitatively charactenzed, digitally represented and archived both as stored digital infoπnation and as a defined reagent hbrary (e.g., analytical, diagnostic, prognostic and momtonng use). Attachment of a first molecule or functional group to a second molecule or functional group, e.g., a nucleotide, a selected molecule, or a particular chemical group compnsing a selected molecule or nucleotide may be site-specific, site-directed or regiospecific, for example, by denvatizing a particular portion of a selected molecule or nucleotide or by chemical, enzymatic or biological synthesis of a molecule, preferably a polymer, more preferably a heteropolymer and most preferably an ohgonucleotide, compnsing a selected molecule, modification, monomer or analog at a defined position. Site-specific, site-directed or regiospecific attachment or modification means preparation of a conjugate or deπvatized molecule compnsing a first molecule (e.g., a selected molecule or nucleotide) and a second species (e.g., a second molecule, a new chemical group, plurality of new chemical groups, or a solid support) wherein the second species is attached to the first molecule at chemically, functionally or topologicalh defined sιte(s). Site-specific and site-directed attachment typically involve attachment to a particular chemical moiety, such as a reactive group or site that specifically binds a hgand or receptor (i.e., an epitope), while regiospecific attachment typically related to the topological position of the attached species rather than on the particular chemical site. However, the art recogmzes some overlap between these terms. Nucleotides descnbed herein are replicatable and may exist in DNA, RNA and chimenc forms Claimed nucleotide compositions and methods therefore include not only the descnbed, preferred, selected or sense form ot a specified nucleotide, but also any corresponding RNA or DNA or chimenc form and any conesponding sequence compnsing backbone modifications, deπvatized nucleotides or nucleotide analogs and any conesponding sequence further compnsing one or more promoter or pnmer annealing sequences and any complementary sequence counteφart, e.g., as may be required or formed dunng replication. Nucleotide sequences and self-assembling groups of nucleotide sequences may be produced by biological and synthetic nucleic acid production techmques, including, but not limited to, recombinant methods, enzymatic methods and chemical methods, including automated nucleic acid synthesis. Amplification methods including, without limitation, PCR, LCR, Q-beta rephcase, 3SR, TAS, RCR, CPR, nbonuclease H or reAMP methods may be used not only to synthesize or replicate, but also to detect, evaluate, charactenze and sequence nucleotides descnbed herein. In a prefened aspect of the invention, nucleotide-based compositions descnbed and claimed herein compnse not only specified defined sequence segments required for specific binding and hybndization to selected molecules and nucleic acid sequences, but also effector recognition sites (e.g., promoter sequences) and/or annealing sequences (e.g., for PCR pnmers) for enzymatic modification, replication, amplification and/or detection of all or part of a constituent nucleotide. Discrete structures of the invention may be partially or fully replicatable, meamng that one or more nucleotide sequences compnsing a discrete structure may be synthesized, replicated, detected or characteπzed using a nucleic acid amplification system to replicate and/or detect a defined sequence segment, a group of defined sequence segments or any portion thereof compnsmg suitable promoter and/or pnmer annealing sequences. Alternatively, degenerate ohgonucleotide pnming may be used to amplify nucleotides compns g randomized or undefined sequence segments. Selected molecules or selected nucleic acid sequences specifically bound or hybπdized to nucleotides, modified nucleotides or nucleotide analogs compnsing a discrete structure of the invention may optionally be covalently attached to one another or to one or more nucleotides compnsing a defined sequence segment of the discrete structure, e.g., 5 using heterobifunctional crosshnking reagents and/or UV irradiation, to create a relatively stable, nondissociable and/or permanent discrete structure. Covalent attachment to a defined sequence segment compnsing a discrete structure is preferably directed to a functional group compnsing only one particular nucleotide, modified nucleotide, nucleotide position, nucleotide analog, type of nucleotide or group of nucleotides. Covalent attachment to a 0 selected molecule, selected nucleic acid sequence or conjugate compnsing multiple functional groups and/or multiple types of functional groups (e.g., a macromolecule, polymer or conjugate such as a protein or protem-hgand conjugate) may advantageously be directed to a single functional group, pair or group of functional groups that is uniquely represented, umquely available or selectively accessible or addressable (e.g., tor 5 topological, positional, steπc, electrostatic, kinetic or conformational reasons) in the selected molecule, selected nucleic acid sequence or conjugate. Alternatively, regiospecific covalent attachment of nucleotides to noncovalently bound molecules compnsing multiple functional groups and/or multiple types ot functional groups may be achieved without stringent chemical selectivity by adjusting reaction conditions (e.g., crosshnker selection, incubation 20 time, temperature, pH and buffer conditions, reagent concentrations, photoactivation options) to favor proximity-dnv en bonding between closest-approach reactive functional groups on the docking surfaces of the noncovalently bound molecules (e.g., the surface of a macromolecular selected molecule specifically bound to the surface of a defined sequence segment). In a pretened mode oi operation, covalent attachment ot nucleotides or selected 25 molecules compnsing a discrete structore is accomplished by selective modification of particular or u que functional groups on the nucleotιde(s) and/or selected molecules to be covalently conjugated or by related site-directed or site-specific covalent modification methods known in the art, including enzymatic methods (e.g., Fisch et al. (1992) Bioconjugate Chemistry 3: 147-153; Gaertner et al. (1992) Bioconjugate Chemistry 3:262- 30 268; Offord ( 1990) In: Protein Design and Development of New Therapeutics and Vaccines (Eds. J.B. Hook and G. Paste), New York: Plenum, pp. 252-282). Aptamers are single-stranded, partially double-stranded or double-stranded nucleotide sequences capable of specifically recognizing a selected nonoligonucleotide molecule or group of molecules by mechanisms other than Watson-Cπck base painng or 35 tπplex formation. The molecule or group of molecules specifically recogmzed by an aptamer is referred to herein as the aptamer target, aptamer receptor, or aptamer binding partner. Synthetic aptamers are defined sequence segments or conjugated defined sequence segments not heretofore known to occur in nature and function as biological recognition sites which are capable of specifically binding a nonoligonucleotide molecule or group of molecules. Aptamer conjugates are conjugates compnsing an aptamer and a second molecule and includes aptamers compnsing nonnucleotide molecules or moieties introduced dunng as well as after nucleotide synthesis, e.g., by incorporation of deπvatized nucleotides or nucleoside tπ phosphates, labeled nucleotides, biotinylated nucleotides, nucleotide ligands, nucleotide receptors, conjugated nucleotides, nucleotides deπvatized with nonnucleotide ligands or receptors, nonnucleotide molecules and the like. An aptamer conjugate is refened to herein as a synthetic aptamer if the conjugate is not heretofore known to occur in natore, regardless ot the nucleotide sequence compnsing the aptamer. Discrete aptamenc structures are capable of prov iding functional coupling between a selected molecule which is not an aptamer target, preferably a ligand or a receptor or a molecule conjugated to a ligand or receptor, and a selected molecule which is an aptamer target, preferably an effector molecule and more preierably a signal-generating species or a drug. Aptamenc devices of the instant invention include multimolecular switches, multimolecular transducers, multimolecular sensors and multimolecular delivery systems compnsing synthetic aptamers or aptamer conjugates. Nonaptamenc multimolecular devices include nonnucleotide multimolecular devices and nucleotide-based multimolecular devices lacking a sequence known to be an aptamer. Tethered specific recogmtion devices are stimulus-responsive multimolecular structures compnsing a molecular scaffold and at least two members of a specific binding or shape recogmtion pair or four members of two different specific recogmtion pairs, each member being cov alently or pseudoirreversibly attached to the molecular scaffold. Different specific recognition pairs means at least two specific recognition pairs whose four members compnse at least three different chemical identities. Nonaptamenc, nucleotide-based multimolecular dev ices compnse at least either two specific binding or shape-specific recogmtion partners tethered to the molecular scaffold ot a tethered specific recogmtion device or two conjugated specific binding or shape-specific recogmtion pairs brought together within a single multimolecular structure in a spatially controlled manner by site- specific or position-directed attachment to a sequence of nucleotides. Nucleotide-based devices of the instant invention can be used to position even multiple specific binding pairs with virtually indistinguishable specificities. For example, a receptor-first effector molecule conjugate can be specifically bound to a ligand-modified nucleotide at a first sequence position (e.g., a defined nucleotide position toward the 3' end of a sequence) dunng solid phase synthesis of a defined sequence segment. Unbound receptor-first effector molecule conjugate is then removed pnor to continuing nucleotide synthesis in the 3' to 5' direction. A receptor-second effector molecule conjugate can then be specifically bound to a hgand-modified nucleotide at a second position (e.g., toward or at the 5' end). In this manner, different specific binding pairs with similar or identical specificities can be positioned along a defined sequence segment dunng synthesis. Similarly, a first hgand-conjugated defined sequence segment specifically bound via its ligand to a first molecular effector-receptor conjugate (e.g., defined sequence segment- biotin/av ldin- peroxidase) can be ligated to a second hgand-conjugated defined sequence segment specifically bound via its ligand to a second molecular effector-receptor conjugate (e.g., defined sequence segment-biotin/avidin-glucose oxidase). In this case, controlled positioning of the two different, albeit closely related, specific binding pairs relies on the specificity provided by enzymatic hgation of two conjugated defined sequence segments. Another way to position two different specific binding pairs having indistinguishable specificities is to hybndize the two specific binding pair-defined sequence segment conjugates to a common linker ohgonucleotide, thereby torming a discrete structore with nucleotide-ordered specific binding pairs. In a prei erred aspect of the instant invention, at least one nucleotide compnsing a defined sequence segment is a modified nucleotide or nucleotide analog selected, preferably by combinatonal selection and/or high-throughput screemng of a diverse library compnsing modified nucleotides or nucleotide analogs, for the ability to specifically bind a selected molecule, e.g., a ligand, effector or receptor molecule. In this way, a specific binding partner, i.e., a modified nucleotide compnsing a ligand or receptor, can be conjugated in a positionally defined manner to a defined sequence segment by chemically or enzymatically synthesizing the defined sequence segment and including the modified nucleotide or nucleotide analog at a defined position. Also, specific binding or shape recognition pairs can be conjugated to defined positions of a defined sequence segment by producing and/or hgating the defined sequence segment with modified nucleotides or nucleotide analogs compnsing ligands or receptors, optionally modified nucleotides or nucleotide analogs identified by screening and or selection oi a diverse mixture or combinatonal library tor candidates capable of specifically binding a selected molecule, preterably a ligand, receptor, or effector molecule. Inclusion of modified nucleotides or nucleotide analogs compnsing selected molecules, e.g., ligands and receptors, in defined sequence segments provides a convenient method for conjugating ligands, receptors and specific binding or shape recogmtion pairs to nucleotide-based dev ices Nucleotide ligand and nucleotide receptor refer to molecules or functional groups compnsing or attaching to deπvatized nucleotides, nucleotide analogs, nucleotide-encoded chemicals and nucleotide-encoded chemical, shape and sequence hbranes. Selection ot a nucleotide ligand, nucleotide receptor, or a pair or group of nucleotide ligands and/or nucleotide receptors compnsing a single nucleic acid molecule or a plurality of nucleic acid molecules is preferably achieved by screemng or selection of a mixture of synthetic nucleotides, preferably a diverse library of chemically deπvatized nucleotides, more preferably a diverse library of nucleic acid molecules compnsing fixed or partially randomized sequences having at least one denvatized nucleotide per nucleic aαd molecule and advantageously having at least two denvatized nucleotides per nucleic acid molecule, more preferably a nucleotide-encoded chemical library. Selection is preferably achieved by screening and selection of a library of diverse hbranes, each diverse library diversified with respect to a different sequence, shape, chemical parameter so as to explore different regions (e.g., of chemical space) or dimensions (i.e., of diversity space) of chemical, shape or sequence space. Selection of templates for multimolecular dev ices and tethered recogmtion devices of the instant invention is optionally achieved by explonng positional space, i.e., by screening and selection of nucleotide hbranes, advantageously nucleotide-encoded chemical hbranes, compnsing at least two preselected defined sequence segments, nucleotide ligands and/or nucleotide receptors, wherein the hbrary is randomized with respect to the positions of pairs or groups of preselected deiined sequence segments, nucleotide ligands and/or nucleotide receptors compnsing member nucleic acids ot the hbrary. Libranes may be diversified in chemical space by denvatization at usefully modifiable positions of naturally occurnng nucleotides and at novel sites compnsing synthetic nucleotide analogs (i.e., novel bases). A nucleotide ligand or nucleotide receptor may be selected to specifically bind an identified molecule compnsing a ligand, receptor, structural molecule or a molecular effector. Where the identified molecule is a receptor, the selected specific binding partner is typically refened to herein as a nucleotide ligand. Where the identified molecule is a hgand, the selected specific binding partner is typically refened to herein as a nucleotide receptor. In preferred embodiments of the instant invention, paired specific recognition devices and tethered specific recognition devices compnse at least two specific recognition pairs, optionally at least two specific binding or shape recognition pairs (e.g., two ligand-receptor pairs), w ithin a single multimolecular structure or multimolecular dev ice. A nucleotide ligand compnsing a first specific binding pair (i.e., a nucleotide ligand and its receptor) may also be a receptor compnsing a second specific binding pair (i.e.. an (aptamer) ligand and a (nucleic acid ligand) receptor). Similarly, a nucleotide receptor may also be a hgand. The distinction between nucleotide ligands and nucleotide receptors is therefore not compositional, but contextual, discretionary and optionally arbitrary. Selection of nucleotide ligands and nucleotide receptors, e.g., by combinatonal synthesis and selection oi a diverse library compnsing denvatized nucleotides and or denv atized nucleotide analogs, enables assembly of multimolecular dev ices with heretofore unknown specific recogmtion properties. In a particularly preferred embodiment, selected nucleotides with designer specificities (i.e., nucleotide ligands and nucleotide receptors) are incorporated into multimolecular drug dehvery systems, multimolecular transducers, and multimolecular switches, particularly multimolecular sensors for detecting and charactenzmg heretofore unknown receptors and ligands, e.g., plant, animal, microbial and viral receptors discovered through genomic and proteomic research and corresponding newly discovered ligands, as well as multimolecular sensors for detecting and momtonng, e.g., hazardous waste, environmental pollutants, chemical and biological weaponry, agncultural diseases, pests and pesticides, food, chemical and biological contamination, analytes for momtonng industnal, chemical and iood production and processing, and the like In another prefened mode of operation, selected nucleotide ligands and nucleotide receptors compnsing defined sequence segments are used to speciiically recognize and assemble selected molecules and conjugated defined sequence segments into useful multimolecular dev ices, particularh multimolecular transducers, multimolecular switches and multimolecular sensors for industnal production, processing and testing, particularly tor microelectronic and micro! abπcated dev ices, microelectromechamcal systems and submicron-scale products and systems requinng nanofabncation and, preferably , molecular-scale manuiactunng Sequences ot nucleotides descnbed herein, l e deiined sequence segments comprising nucleotides, can also be selected for the ability to speciiically bind selected nonoligonucleotide molecules not heretoiore known to speciiically bind the selected detined sequence segments Deiined sequence segments capable ot speciiically binding selected molecules, preierably ligands, receptors, structural molecules and etfector molecules, are particularly useful and necessary constituents of aptamenc and heteropolymenc multimolecular devices of the instant invention Particularly prefened constituents of such devices are defined sequence segments capable oi speciiically binding etfector molecules, particularly drugs and signal-generating species and more particularly drugs and signal- generating species not heretofore known to specifically bind nucleotides, thereby enabling nucleotide-based recognition and molecular positiomng, preierably w ithin functional coupling distance, of useful effector molecules, preferabh pairs or groups of effector molecules that Junction cooperatively or collectively when brought into close spatial proximity , and optionally effector molecules in combination with other types ot selected molecules (e g , ligands, receptors or structural molecules) Of particular importance is the ability to select defined sequence segments compnsing aptamenc and heteropolymenc devices tor the ability to specifically bind identified molecules, preferably etfector molecules and more preferably signal-generating species, that hav e no heretofore known specific binding partners, thereby transposing said identified molecules into ligands or receptors A particularly prefened method for selecting defined sequence segments for the ability to specifically bind identified molecules relies upon the selection cnteπon that a nucleic acid molecule from a diverse mixture compnsing nucleic acids be capable ot attaching two identified molecules compnsing or attaching signal-generating species so as to render the two attached identified molecules detectable, preferably as a result of position-dependent functional coupling between two signal-generating species Alternatively important is the selection of nucleotide ligands and nucleotide receptors, l e , chemically deπvatized nucleotides and nucleotide analogs capable of specifically binding identified molecules, particularly effector molecules and more particularly drugs and signal-generating species, thereby transposing the identified molecules into ligands and receptors Selection of such heretofore unknow n nucleotide ligands and nucleotide receptors enables nucleotide-directed positioning of limitless combinations of ligands, receptors and specifically bindable effector functions withm useful MOLECULAR MACHINES. Deiined sequence segments of the invention are impnntable, e.g., using a paired nucleotide-nonnucleotide hbrary, i.e., an impnnt hbran . Impnnting enables the transposition of a nucleotide-based defined sequence segment into an impnnted segment w hose composition is dictated by the molecular medium of the impnnt hbran . The compositional diversit} of an impnnted segment approaches the knowable limits of molecular sequence and shape space, limited only by the div ersity of the set ot all molecular hbranes that can be functionalh' coupled to a nucleic acid hbran, a modified nucleotide hbran or. more generally, a nucleotide hbran . The basic assembh units tor MOLECULAR MACHINES are impnntable precursor or parent molecules or segments (i.e., plastic segments), optionalh multiv alent segments and/or multisegment segments compnsing multivalent plastic templates, onginating f rom a replicatable parent nucleotide sequence, w herein the lineage trom parent to progen} is nonbiological, i.e., does not compnse a natural hereditary mechanism involv ing genetic replication, transcnption and expression of heretoiore kno n nucleic acid sequences. Parent and progen} plastic segments and templates ma} compnse an} combination of nucleotides and/or nonnucleotides attached by any know n or knowable method, covalent or noncov alent, specific or nonspecific, lomc or nomonic, reversible or pseudoineversible or inev ersible. including binding, bonding, association, lomzation, intercalation, coordination, hydrophobic interactions, chelation, incorporation by genetic, recombinant. transgenic. chemical, enzymatic and physical methods, e.g., nanomechamcal s} nthesιs and manipulation, without limitation. Plastic segments compnsing MOLECULAR MACHINES oi the inv ention, preferabh plastic segments identified b} screening and selection oi poly div erse libranes compnsing nucleic acids, nucleotide and nucleotide-encoded nonnucleotide molecules, are capable of all forms of molecular and catalytic recogmtion between nucleotide and nonnucleotide molecules, including specific binding, hybndization, structural shape recognition and catalytic recognition. Also, as will become apparent on reading this disclosure, the recognition properties of structural shapes and surface features compnsing substrates, structures and matenals can be transposed into plastic segments and templates ot the instant invention, erasing the definitional boundary between specific surface attractivity and molecular shape-based recogmtion. Plastic segments and templates thus compnse a universally plastic molecular structure-activity-surface medium capable of all types of surface attractivity and recogmtion. The ability to design, select, shape, engineer and advantageously evolv e nucleoplastic segments and templates to encompass any an all selected recogmtion t unctions provides the basis for powerful and universal molecular attractors capable of assembling limitless forms and functions for development MOLECULAR MACHINES disclosed herein. The complementan Enabler is the Universe of useful molecules from which to identify and assemble cooperative consortia of functionally coupled selected molecules, i.e., ligands, receptors, structural molecules and effector molecules. Not only does the Universe of willfully known selectable molecules (i.e., selected molecules pπor to selection) provide a div erse, multimedia palette for expression of bimolecular and multimolecular synergies by molecular attractors (i.e., plastic templates), this same abundant toolkit of selectable molecules provides a feedstock stream of molecular structures and activities capable of being cast and recast through a nucleotide hbrary amplifier. The molecular structure-activity space ot the feedstock stream can be expanded, projected, reflected, distorted, permuted and projected into heretofore unknown regions of div ersity space. At least two compositional dimensions of plastic segments and templates compnsing MOLECULAR MACHINES distinguishes them from all art-know n substances, and the practical, commercial ramifications are heretofore unimaginable. First is the heretofore unexplored positional diversity addressable by simultaneous or sequential covalent, noncovalent, specific, nonspecific, pseudoine ersible, reversible, small and large molecule modification and conjugation of molecules, sequences, polymers and templates at a plurality of sites or positions, (i.e., the realm of proximity space). Second is the plasticity of the instant plastic segments, i.e., plastic nucleoprobes or nucleoplastic probes. Proximity space and functional coupling space refer to the structural and functional conelates of positional space. Positional space in practice, as embodied herein, means the intersection between the proximity space of a nucleoplastic hbrary of plastic nucleoprobes with the informational space comprehended by a massively parallel informational search engine. In other words, iunctional coupling ot the nucleoplastic molecular diversity generator with a suitably ( parallel )N, fast and computationally intelligent search engine defines the field oi positional space practically accessible to the willful artisan, preferably aided by automation, v anation and selection of processing modalities and library -search engine ieedback systems and evolution. Computational intelligence depends in large part on the sensitivity and specificity ot the intenogation process, e.g., the human-machine interface. Advantageously , machine, generator and machine-generator evolution are possible and likely. Automation-enhanced vanation and selection of search parameters, hypotheses, and library expression by the molecular diversity generator and search engine oscillating m paired and functionally coupled closed-loop feedback cycles provide the potential for divergent and self-sustained exploration of diversity planes included but not limited to positional space. Positional space as defined by the actuahzable intersection between library - generated molecular space and machine-palpable informational space will depend in large part on the ultimate director. At issue is whether the functionally coupled (molecular/machine) diversity search will be nucleoplastic library-directed, search engine- directed, w lllfully directed, or some combination thereof. Or none of the abov e. Exploration is optionally guided by artificial intelligence and/or willful direction. The multidimensional diversity in structure-activ lty -shape space of the instant polydiverse nucleotide hbranes distinguishes them from pnor art nucleic acid libranes diversified only in sequence and or nucleotide chemistry , e.g., for selection of aptamers, nbozymes or chemically modified nucleotides. Enhanced πbozyme activity has been demonstrated using a contiguous allostenc deoxynucleotide sequence and by 2'-0- methylation (Goodchild ( 1992) Nucleic Acids Research 70-4607-4612). A πbozy me-based diagnostic method capable of detecting nonoligonucleotide analytes has also been descnbed (Bockman et al. ( 1993) International Conference on Nucleic Acid Medical Applications, Cancun, Mexico, January 26-30), implying use ot a πbozyme with both catalytic and specific binding properties. An allostenc molecular sw itch compnsing internally hybndizable switch sequences and a DNA-binding biological recognition site has also been descnbed (i.e., Lizardi et al., U.S. 5,118,801). Howev er, the pnor art does not provide access to the diversity space encompassed by MOLECULAR MACHINES compnsing defined sequence segments, plastic segments, synthetic templates and/or molecular scaffolds of the instant inv ention. A suφnsingly enabling inventive step of the instant disclosure which is lacking in the pπor art is the diversity space encompassed by defined sequence segments compnsing MOLECULAR MACHINES. Particularly and advantageously , defined sequence segments and combinations of defined sequence segments compnsing different embodiments of MOLECULAR MACHINES and paired MOLECULAR MACHINES include nucleotide ligands, nucleotide receptors, nucleotide catalysts, aptamers. and conjugated nucleotides compnsing ligands, receptors, effector molecules and structural molecules. Defined sequence segments compnsing these multidimensional functionalities, as well as nbozymes, catalytic nucleic acids and synthetic oligonucleotides kno n in the art, can be selected with single-molecule resolution by methods descnbed herein. The instant single-molecule detection, amplification and sequencing methods are enabling for isolation and functional charactenzation of individual short, single-stranded or double-stranded, πbonucleotide, deoxynbonucleotide or chimenc, modified or unmodified, randomized or encoding (i.e., informational), conjugated or hybndized nucleotides or any combination thereof, e.g., a nboz me functionally coupled to an aptamer-bound enzyme. Importantly , the functional coupling between at least two defined sequence segments, selected nucleic acid sequences and/or selected molecules of the invention is best achieved by imaging and quantifying functional activity at the single-molecule lev el, i.e., by measunng catalysis, fluorescence, luminescence or electron transfer within or between single molecules or multimolecular structures. More particularly , and heretofore unknown in the art, are structural shape recognition probes compnsing defined sequence segments selected for the ability to recognize surface features compnsing chemically homogeneous - I l l - and doped structural surfaces, e.g., carbon, silicon, gallium arsenide, plastics, glasses, polymers, semiconductors and synthetic semiconductors, metals and synthetic (i.e., organic) metals, insulators, Mott insulators, bucky balls, carbon nanotubes, carbon nanorods and emerging nonbiomimetic mimics of organic and inorganic surfaces. This ability ot the defined sequence segments of the present invention enables grafting, templating and impnnting of heretofore chemically bland surfaces. Furthermore, plastic impnnts (e.g., nonnucleotide molecules, monomers and polymers, including nucleotide-encoded nonnucleotides) and the progeny ot paired nucleotide-nonnucleotide library evolution (i.e., (hbranes)N), enable the transposition of 1) nucleotide recognition properties into nonnucleotide recogmtion elements and 2) structural shapes (i.e.. surface features) into molecular shapes. In turn, surface features (e.g., nanofabncated and micromachines features) can be identified by screening and selection of matenals and patterning methods yielding structures poly div ersified in surface attractivity The implications oi this heretofore unrecogmzed potential to exploit the inteφlay between molecular div ersity and structoral shape diversity , i.e., the mutually synergistic plasticities ot chemically bland, structurally diverse surfaces (e.g., designed, selected or engineered surface teatures) and chemically diverse, structurally autonomous molecules are wondrously enabling tor a daunting array of practical, commercially v aluable applications. For example, the long-anticipated and heretofore unreconαlable marnage between biological/biomimetic effectors (renowned for diversity in structure-activity-shape space), and inorganic substrates, (renowned for surface uniformity, semiconductiuty, structural integπty and atomistically precise sculptabihty, i.e., chemical blandness) can finally be envisioned as a harmonious coselection of specific surface attractivity against molecular specificity. The v lrtually limitless plasticity of chemical, sequence and shape space represented by deiined sequence segments compnsing defined sequence segments, plastic segments, templates and molecular scaitolds enables systematic, nucleotide-programmable and nucleohbrary -directed, willfully automated and supen ised selection of novel biomimetic impnnts of industnal surfaces, e.g., silicon chips, CDs and DVDs. Conv ersely and heretoiore unknown in the art, industnal surfaces can be plasticized (e.g., div ersified in structural shape space) to accommodate the specific attractivity preferences oi a selected plastic, biomimetic matnx, e.g., a synthetic polymer, preferably a durable, scalable, process-fπendly and inexpensive polymer, more preferably a polymer capable oi self-assembling on the industnal surface, advantageously a smart polymer doped, supplemented or blended with a self-rephcating, self-assembling MOLECULAR MACHINE. Defined sequence segments compnsing synthetic heteropolymers, multimolecular devices, discrete structures and nucleotide-based molecular scaffolds of the invention include replicatable nucleotides, meaning that all or part of one or more defined sequence segments can be synthesized or detected using amplification systems well known in the art. PCR, LCR. Q-beta rephcase, 3SR, TAS, RCR, CPR, πbonuclease H or reAMP methods, for example, may be used to detect or amplify a defined sequence segment, a group of defined sequence segments or any portion thereof compnsing suitable promoter and or pnmer annealing sequences. A randomized nucleotide sequence is not a defined sequence segment unless and until it is identified as a recognition partner of a selected target, whereupon charactenzation and/or sequencing is imminent. Defined sequence segments capable of specifically binding identified or selected molecules are aptamers. Defined sequence segments and selected nucleic acid sequences of the instant inv ention may be labeled or modified at defined positions by methods w ell know n in the art as site-specific, site-directed and regiospecific attachment, conjugation and modification, including synthesis of oligonucleotides with modified nucleotides, conjugated nucleotides, nucleotide analogs and spacer modifiers at user-specified positions. Uniformly or arbitraπly labeled or modified nucleotides are not considered herein to be labeled or modified at deiined positions. A defined sequence segment compnsing a first MOLECULAR MACHINE may hybndize or specifically bind to a selected nucleic acid sequence or selected molecule compnsing a second MOLECULAR MACHINE, thereby attaching the two MOLECULAR MACHINES. The resulting product, which may be referred to as a single MOLECULAR MACHINE or a pair of MOLECULAR MACHINES, may attach to other MOLECULAR MACHINES by methods descnbed herein, including specific binding, hybndization, site- directed covalent attachment, pseudoineversible attachment and the like. Mimetic multimolecular structures and multimolecular devices of the instant invention may be designed and prepared using nucleolibrary-directed products and processes to create mimetic, impnnted, transposed, transcnbed, replicated and complementary segments, templates, multimolecular structures and multimolecular devices, i.e., nucleotide-based and nonnucleotide replicates, clones, mimetics, impnnts. conjugates and progeny of defined sequence segments compnsing parent multimolecular structures. Replicates, impnnts and mimetics may be prepared with varying degrees of fidelity ranging from identical or approximately identical clones to arbitrary, randomized, combinatonal and/or w lllfully ev olved or directed v anants and/or mutants. Quasirev ersibihty refers to specific recognition that can be dissociated, displaced or reversed under certain conditions of use, whereas pseudoinev ersibihty refers to a binding event or bond, association, complex or specific recognition pair compnsing a molecule that cannot be dissociated, displaced, separated, rev ersed or detached under normal conditions of use and hich specific recogmtion pair complex is not formed dunng operation, as distinct from manufacture, of a multimolecular device. For puφoses of the present invention, noncovalent, pseudoineversible attachment of a selected molecule to a multimolecular device is functionally equivalent to covalent attachment in terms of the stability and permanence of attachment, so long as the pseudoineversibly attached molecule is attached dunng multimolecular device manufacture and remains inseparable dunng device operation. An unconjugated ohgonucleotide hybndized to a defined sequence segment of a multimolecular device is said to be hybndized, not pseudoineversibly attached, regardless of the melting temperature of the hybndized duplex. Pseudoineversible attachment of selected molecules may be achiev ed by a number ot methods well kno n in the art, preferably by avidin/biotm or streptavidin/biotin conjugation or by hybndization of selected nucleic acid sequences and/or defined sequence segments having a high degree of complementan ty , but also by methods including, without limitation, ionic bonding, surface adsoφtion, intercalation, tπplex formation, chelation, coordination, hydrophobic binding and high-affinity specific binding, optionally followed by UV irradiation or treatment with a noncovalent stabilizer, cov alent crosshnker and/or photoactivatable reagent. Noncov alent site-specific conjugation oi a selected molecule to a multimolecular structure may be achieved by pseudoineversible attachment, preferably by hybridization of an ohgonucleotide conjugate to a defined sequence segment or by specific binding of an av idin or streptavidin conjugate to a biotinylated molecule or defined sequence segment. A member of a specific recognition pair that specifically binds or hybπdizes dunng multimolecular dev ice operation is not considered pseudoineversibly attached, even if (as may be the case ith a conjugated specific binding pair) the member is required for device function. A selected nucleic acid target detected by a multimolecular sensor, for example, is considered hybπdized and not pseudoineversibly attached to the multimolecular sensor. When used in reference to a multimolecular dev ice, conjugated specific binding or shape recognition pair and specific binding or shape recogmtion pair conjugate mean that operation of the multimolecular device requires the presence of both members of the specific binding or shape recognition pair or, in the case of certain analyte-dependent sensors or target-dependent molecular delivery systems, that the dev ice does not respond to a stimulus or de v er its payload until both members of the specific binding or shape recogmtion pair are present. In either case, a multimolecular dev ice is said to compnse a specific binding or shape recogmtion pair if and only if a useful function is performed by the dev ice hen both members ot the specific binding or shape recognition pair are present and available for specific binding. Hybndized nucleic acid sequences are not considered to be conjugated to one another, nor is a nucleic acid target considered to be conjugated or pseudoinev ersibly attached to a nucleic acid probe. Howev er, a selected molecule may be conjugated or pseudoineversibly attached to a defined sequence segment by conjugation of the selected molecule to an ohgonucleotide and hybndization of the selected molecule-ohgonucleotide conjugate to the defined sequence segment. A selected nucleic acid sequence may be used to pseudoineversibly attach a selected molecule to a defined sequence segment or a multimolecular dev ice by first conjugating the selected molecule to the selected nucleic acid sequence (i.e., an ohgonucleotide) and then hybπdizing the selected molecule-ohgonucleotide conjugate to the defined sequence segment. Selected molecules, identified molecules, selected nonoligonucleotide molecules and identified nonoligonucleotide molecules may be identified from natural or synthetic sources, particularly by screemng and selection of a library compnsing natural or synthetic molecules. A selected molecule compnsing a first MOLECULAR MACHINE may specifically recognize a selected molecule or selected nucleic acid sequence compnsing a second MOLECULAR MACHINE, thereby attaching the two MOLECULAR MACHINES. The attached MOLECULAR MACHINES, which may be referred to as a single MOLECULAR MACHINE or a pair of MOLECULAR MACHINES, may further attach to other MOLECULAR MACHINES, e.g., by specific binding, hybndization, site-directed covalent attachment, pseudoineversible attachment, to torm pairs or groups of MOLECULAR MACHINES and optionally pairs or groups therelrom. Library -selected molecules of the invention are heretofore unkno n molecules identified by screening and or selection of nucleotide and nonnucleotide hbranes, including nucleic acid hbranes, nucleotide libranes and nucleotide-encoded chemical libranes. Heretoiore known selected molecules, by contrast, are themselv es used as targets for screemng and selection of nucleotides compnsing aptamers. nucleotide ligands, nucleotide receptors, nucleotide catalysts, catalytic nucleotides and structural shape recognition probes. Once a library-selected molecule is identified and therefore becomes known, it may, in turn, be used as a selected target molecule for screemng and selection of a nucleic acid library or nucleotide-encoded chemical library to identify heretofore unknown aptamers, nucleotide ligands, nucleotide receptors, nucleotide catalysts, catalytic nucleotides and structural shape- recognition probes. This iterativ e and advantageously automatable process, i.e., lteratively selecting first a heretofore unknown probe tor an identified target and second, the probe being identified, a heretofore unknow n recogmtion partner (i.e.. an impnnt) for the library- selected probe, is both divergent and self-sustaining. By lteratively selecting library -selected product(s) ot a first evolutionary selection process as target(s) tor a second evolutionary selection process, the ensuing self-sustained cycling enables systematic evolution of the evolutionary process into heretofore unavailable regions of shape space. The cycle is divergent in exploring both nucleotide and nonnucleotide shape space with positive feedback, transcending the chemical and sequence bias of any single impnnt medium. This cyclic process enables identification of limitless novel, useful and heretofore unknown molecules compnsing nucleotides, nonnucleotides and hybnd and chimenc combinations thereof. Each generation of precursor molecule (i.e., known, selected target) and product molecule (i.e., library -selected probe) is either itself replicatable, advantageously self- rephcatable, or it is impnntable into replicatable partner (i.e., impnnt or probe). In each generation of the cycle, new levels of diversity can be introduced by arbitrary, rational, randomized and or combinatonal chemical, enzymatic and/or genetic methods, including, e.g., unfaithful replication. The suφπsing result that emerges w ith the ability to transpose a selected nonnucleotide target (i.e., precursor) into a library -selected nucleotide impnnt (i.e., product) is that a first library can be coupled to second library, much as a donor effector species can be functionally coupled to an acceptor species. By selecting a population of selected molecules (e.g., immunoglobulins ot selected type or antibodies of selected specificity), it becomes possible through iterative screemng and selection ot a population of impnntable nucleotide and nucleotide-encoded libranes to evolve a mapping library compnsing a set of nucleotide ligands, nucleotide receptors and aptamers, including shape-specific recognition partners, that correspond in molecular shape space (i.e., specific recognition diversity space) to an impnnted library of a selected population oi nonnucleotide molecules, i.e., a receptive audience In other words, screening and selection of vastly diverse libranes of diverse nucleotide and nucleotide-encoded libranes, enables selection, collection, and continued ev olution ot a receptiv e audience compnsing the set of molecular and structural shape probes that recogmze members ot the selected population. Evolution of a useful mapping library requires a vastly higher order ot diversity of the collective impnnt hbranes (i.e., (probing hbranes)^) over the selected population of selected molecules (i.e., (selected targets)xN or selected population). This balancing of (probing library )N diversity (i.e., probing plasticity) against (selected targets)xN) diversity is achieved simply , in pnnciple, by 1) maximizing probing plasticity (e.g., by chemical, sequence and positional diversity and by self-sustained amplification with varying fidelity), and 2) minimizing the molecular and population diversity of the selected population (e.g., by limiting the population, optionally by willful selection, fractionation and or punfication), and 3) evolving the receptive audience in time, advantageously by illful and automatable self- sustained and divergent amplification and selection. This initially labonous but ultimately automatable process of reciprocal transposition between selected populations of nonnucleotide targets and polydiverse nucleotide hbranes is important, useful and enabling in several respects First, polydiverse nucleotide (hbranes)^ provide a uniquely plastic and high- resolution molecular diversity generator that enables v ast regions of diversity space to be explored w ith single-molecule resolution. Second, the replicative and mutational propensities ot nucleotides, particularly divergent and self-sustained amplification with varying fidelity , enables novel shapes to be expressed and reflected off or into nonnucleotide shape media (e.g., (lιbranes)N). Iterative cycles ot expression and reflection enable comprehensive probing of heretofore inaccessible regions of molecular and structural shape space, i.e., regions unavailable within directed evolutionary time. Third, impnnting of nonnucleotide populations into nucleotide libranes, enables single-molecule detection and identification of useful molecular shapes from any medium compnsing a diversity of molecular shapes (e.g., random, randomized, combinatonal, natural or synthetic peptides, proteins, small molecules, monomers, dimers and polymers, including biologically diverse and biologically diversified sets). Fourth, the single-molecule detection capability provided by nucleotide amplification enables a thorough and efficient probing of structural space, e.g., identification of specifically attractive surfaces by methods heretofore unknown in the art (e.g., the identit ication of shape recognition probes for inorganic matenals, surfaces and structures, including nanostructures and microstructures (e.g., nanofabncated circuits, MEMS and NEMS de ices, bucky balls, carbon nanotubes, carbon nanorods, and the like) Fifth, the suitability of nucleotides for construction of, e.g., bivalent and multivalent nucleotides of the instant invention enables selection and impnnting oi positioning templates capable ot assembling a div erse array ot useiul MOLECULAR MACHINES compnsing functionally coupled selected target molecules Sixth, template-based MOLECULAR MACHINES can then be impnnted into nonnucleotide matenals selected tor suitability to the intended puφose of the product. For in vivo applications, templates compnsing, e.g., nucleotide, peptide, protein and dendntic polymers modified for oral availability and resistance to enzymatic degradation are prefened Matenals selection cnteπa will v ary, e.g., for cosmeceutical, diagnostic, analytical, microelectronic, automotive, military , food processing, chemical processing, env ironmental, agncultural, consumer electronic, industnal polymers, paints and coatings, industnal enzy me reactors and packaging matenals. Sev enth, the shape plasticity of polydiv erse nucleotide (hbranes)^ amplified by temporal e olution enables transposition of highly diverse selected populations of selected nonnucleotide molecules into impnnted mapping hbranes useful in, e.g., clinical diagnostics, momtonng and prognostic modalities (vide infra). Furthermore, the combination ot nucleotide-dependent replication and template- directed self -assembly prov ides a general approach tor dev elopment of sy nthetic selt- rephcating and self-assembling MOLECULAR MACHINES In a particularh prefened willful direction ot the instant invention, highly plastic, replicatable. digitally encoded and dynamic (e.g., w illfully ev olv ing) nucleotide mapping branes are selected first to maternal selected poρulation(s) pπor to conception and subsequently to an embryonic and/or peπnatal selected populatιon(s), advantageously including at least a first map of a selected population compnsing immune globulins, immunoglobulin antibodies and lymphocytes comprising a defined fraction of umbilical cord blood. Selected maternal (target)xN-denved and umbilical cord (target)xN-deπved mapping hbranes are amplified, sequenced and digitally archived as a baseline impnnt of the immune repertoire, as transposed into nucleotide-encoded (molecular and structural) shape space. Ontogenetic development of immune competence is then imaged ov er time by evolving the receptiv e audience, amplifying, sequencing, digitally encoding the information and companng the digitally encoded shape space against baseline and cumulative molecular and structural shape images as transposed into information space Using paired nucleotide- nonnucleotide libranes iunctionally coupled to an informational system, a product of a first hbran selection step is used as a target for a second hbran selection step There is no heretofore known limit to the molecular diversity that can be explored, expressed and archived in this type of self-sustainable, divergent evolutionary process The enabling tool tor high-resolution mapping is transposition or impnnting of a nonnucleotide hbran into an amphfiable molecular medium (e g , a nucleotide hbran) Library -selected nucleic acid sequences include, w ithout limitation, an} heretofore unknown nucleic acid sequence, shape, activ it} nucleotide. modified nucleotide or nonnucleotide molecule, particularh including aptamers, nbozymes, catalytic nucleotides, nucleotide ligands, nucleotide receptors, nucleotide catalysts, structural shape probes and sequences or shapes compnsmg at least two recognition elements Also included is an} second nucleotide or nonnucleotide molecule capable of functionally coupling with a first nucleotide or nonnucleotide molecule compnsing a member oi the mixture Importantly, screening and selection of an} nucleotide hbran tor an} nucleotide, nucleotide replicate, impnnt, clone, denv ativ e, mimetic or conjugate ma} be achieved b} single-molecule detection methods disclosed herein Also, selected molecules identified b} screening and selection of a nonnucleotide hbran b} single-molecule detection may be advantageously transposed into nucleotide space, enabling sequencing, charactenzation, digital encoding and archiving nucleotide impnnts of nonnucleotide libranes The importance of this capability will be apparent to the skilled artisan on reading this disclosure Single-molecule selection using polydiverse nucleotide branes enables comprehensive and efficient exploration of div ersity space w ith single-molecule resolution that cannot be achieved using nonamplifiable, noncoded chemical libranes sans single molecule anal} tical techniques This single-molecule resolution is important in the selection and assembh (I e , collection or accumulation) of (target)xN-specιfιc receptive audience members as the selected mapping hbran ev o es in time, preferabh in a w lllful direction Willful directions include, tor example, mapping the immunoglobulin repertoire of an organism, adv antageoush momtonng ontogenetic d}namιcs and the response of the selected population to climcal and env ironmental factors, e g , therapeutic intenention, identifying and charactenzing the antigenic determinants compnsing the set of all autoimmune antibodies in Hashimoto's thyroiditis, mapping the set of lymphocyte cell surface antigens compnsing the cellular immune system and momtonng responses to disease and therapy , and momtonng the molecular and structural shape repertoire ot dynamic elements compnsing the human immune system, including cellular and humoral compartments Single-molecule detection, single-molecule isolation, single-molecule charactenzation, single-molecule identification, single-molecule amplification and single- molecule sequencing relate to resolution at the level ot an individual molecule, an indi idual pair or group of molecules attached to one another, an individual molecular complex, an individual supramolecular or multimolecular assembly or a discrete structure. Single- molecule detection and single-molecule methods refer to methods capable of detecting an individual molecule, an individual pair or group of molecules attached to one another, an individual molecular complex, an individual supramolecular or multimolecular assembly or a discrete structure. Single-molecule detection methods and dev ices of the instant invention include, without limitation, optical force fields, optical tweezers, optical trapping, laser scanmng, laser trapping, scanning probe microscopy, scanning tunneling microscopy, scanning force microscopy, atomic force microscopy , scanning electrochemical microscopy, hybnd scanning probe microscopy techniques, mass spectrometry, spectroscopy, kromoscopy , capillary electrophoresis, microelectrophoresis. on-chip electrophoresis, multiplexed and arrayed electrophoretic methods and detectors; microminatuπzed and nanofabncated optical, spectroscopic, spectrometnc, electrochemical, optoelectronic and electronic detectors; microsensors, nanosensors, integrated on-chip detectors, sensors, transducers and anays; molecular detectors, sensors and transducers; and multimolecular sensors, multimolecular transducers and tethered specific recognition dev ices. A sequence of nucleotides (e.g., a selected nucleic acid sequence) is referred to herein, e.g., as a nucleotide molecule, nucleic acid, nucleotide, nucleotide sequence or ohgonucleotide and not as a conjugate or as a polymer of conjugated nucleotides. However, nucleotides may be refened to as conjugates, e.g., if a nonnucleotide molecule, group or moiety (e.g., biotin, digoxigenin, fluorescem, rhodamine) is introduced either before, dunng or after nucleic acid synthesis, e.g., as a nucleotide analog, modified nucleotide or modified nucleoside tπphosphate. Ligands are molecules capable of specifically binding to receptors by affinity-based attraction that does not inv oh e base pairing between complementary nucleic acid sequences. Conversely , receptors are molecules capable ot specifically binding to ligands. Whereas a ligand and its conesponding receptor are refened to herein as members oi a specific binding pair, complementary nucleic acid sequences are referred to as complementary, hybndizable or members of a specific recogmtion pair but not as members ot a specific binding pair. Molecular recogmtion means and includes specific binding and hybndization, but not specific recogmtion of a surface feature of a specifically attractiv e surface. Overlap can exist among the terms ligand, receptor, effector molecule and structural molecule. The distinction between a hgand and receptor, a structural molecule and a ligand, or a structural molecule and an effector molecule, for example, may in some cases be discretionary . In other cases, a ligand may also be a receptor, a structural molecule and/or an effector molecule, and reciprocal cases are also possible. In still other cases, a selected molecule may function as a ligand or structoral molecule in one context and a receptor or effector molecule in another. Although the meaning of these terms will be apparent to the stalled artisan on reading this disclosure, it will also be apparent that some contextual flexibility is required. A nucleotide recogmtion element is any molecule, sequence or group of nucleotide or nonnucleotide molecules or residues capable of recognition, including, without limitation, molecular recognition, structural shape recognition, and catalytic recogmtion. A nucleic acid molecule compnsing an unconjugated randomized sequence (e.g., a prospectiv e aptamer sequence) and a fixed unconjugated pnmer-annealing sequence is not a synthetic heteropolymer. In other words, where a bifunctional synthetic heteropolymer compnses a first aptamenc sequence segment and a second def ined sequence segment capable of hybndizing, the second defined sequence segment is not an unconjugated pnmer- annealing sequence for an unconjugated pnmer. Conversely , selected nucleic acid sequences that hybndize bifunctional synthetic heteropolymers of the instant invention do not include unconjugated pnmers used to amplify nucleic acid molecules selected from mixtures, pools, or random-sequence hbranes. Mixtures of nucleic acids hav ing both fixed pnmer-annealing sequences and regions of randomized sequence are known in the art, including candidate mixtures irom w hich regions oi randomized sequence may be selected tor the ability to specifically bind a selected nonoligonucleotide molecule (e.g., Ellington and Szostak ( 1990) Nature 346:818-822; Ellington and Szostak ( 1992) Nature 355:850-852; Famulok and Szostak ( 1993) In: Nucleic Acids and Molecular Biology, pp. 271-284 Spnnger-Verlag, Berlin; Famulok and Szostak (1993) J. Am. Chem. Soc. 774:3990-3991 ; Gold et al., U.S. 5,270,163; Green et al. ( 1990) Nature 346: 818-822; Jelhnek et al. ( 1993) Proc. Natl. Acad. Sci. USA 90: 11227- 11231 ; Tuerk and Gold ( 1990) Science 249:505-510: Tuerk and MacDougal-Waugh ( 1993) Gene 737:33-39). Heteropolymenc selected nucleic acid sequences of the instant inv ention also do not include a conjugated ohgonucleotide hybndized to a second defined sequence segment of a synthetic heteropolymer, wherein the ohgonucleotide-conjugated molecule is a ligand or receptor cov alenth attached to a nonoligonucleotide molecule capable ot specifically binding to the first deiined sequence segment oi the synthetic heteropolymer. In other words, the instant disclosure is not directed to biv alent nucleotides capable simply of speαfically binding the nonoligonucleotide moiety (at a first sequence segment) and hybndizing the ohgonucleotide moiety (at a second sequence segment) of an ohgonucleotide conjugate compnsing a nonoligonucleotide molecule conjugated to an ohgonucleotide. Bifunctional. bivalent, multivalent and multifunctional relate to the recogmtion and attachment properties of nucleotide and nonnucleotide molecules, scaffolds and templates. Multivalent in the context of a multi alent heteropolymenc hybnd structure means having at least two specific recogmtion sites in addition to the hybndizable defined sequence segments joining the synthetic heteropolymers compnsing the multivalent heteropolymenc hybnd structure. At least two specific recognition sites compnsing a multivalent heteropolymenc hybnd structore are capable of specifically recogmzing selected molecules or selected nucleic acid sequences which are not the synthetic heteropohmers that make up the multivalent heteropolymenc hybnd structure itself. Structural shapes, structural features and surface featores refer to specifically attractiv e surfaces, i.e., specifically recogmzable structural features of a surface. Surface features include natural, synthetic, designed or selected structures or surfaces, preferably subnanometer- to submicron-sized surface contours, having a two-dimensional or three- dimensional shape, contour, texture, characteπstic, pattern, distnbution, property, configuration, arrangement, orgamzation, order, lack oi organization or order, iorm, trait or peculiarity that can be specifically recognized by a shape-specific recogmtion element. Structural shapes or surface features are optionally designed or selected to be specifically recognizable by a shape recognition partner, preferably a shape recognition partner selected from a diverse mixture of molecules compnsing a library . adv antageoush a library of libranes. In a prefened mode oi operation, surfaces are micromachined and/or nanotabncated w ith a v aπety of structural features, preferably a div ersity ot structural teatures. and coselected against shape recognition libraries. The shape recognition hbranes are preierably nested combinatonal libranes oi libranes explonng, e.g., nucleotide sequence, nucleotide charge, backbone modifications, sequence length, chemical modifications and optionally positional space (i.e., the relationship between pairs and groups ot nucleotide modifications). Surface features that are specifically attractive, i.e., specifically recogmzable by at least one member of a shape recogmtion librar , are selected as useful prospects for template-directed assembly ot MOLECULAR MACHINES. Alternativ ely , selected attractiv e features are used for surface-to-surface registration and bonding In a particularly prefened aspect, diverse modifications are introduced in a single surface, preierably by randomized or combinatonal surface treatments, adv antageously with nanoscale or atomic precision. Tagged molecules compnsing div erse shape recogmtion libranes. preierably nucleic acid libranes or nucleotide-encoded chemical libranes. are then coselected against div erse surface features to identity useiul specific pairs of specifically attractiv e surface shapes and shape-specific probes. Fluorescenth tagged nucleic acids or nucleotide-encoded chemical libranes are prefened. surfaces are adv antageoush imaged b} a combination of optical and scanning probe microscop} (SPM), preferabh fluorescence and atomic force microscop} (AFM), before and after exposure to shape recogmtion libranes. Bound, fluorescenth tagged molecules, preferabh nucleotides. are then isolated and charactenzed, preferably by AFM extraction followed bv single-molecule nucleic acid amplification and/or sequencing. A structoral shape recognition partner ma} , for conv enience, be considered a special case of a specific binding partner, because the art has no suitable term for shape recogmtion sans specificity for chemical identity. As descnbed herein, a shape recogmtion partner is the antithesis of a specific binding partner. The several differences between molecular recogmtion and shape recogmtion will become apparent to the skilled artisan on reading this disclosure. For example, structural shape recognition is specific tor a surface feature compnsing a selected mateπal, not the chemical identity of a constituent selected molecule. Therefore, selected molecules having the same composition as the recogmzed surface Ieature do not necessaπly compete, inhibit or crossreact, as would be the case in specific binding reactions known in the art. Nor do chemicalh related congeners crossreact. Nor do solution phase molecules or even other surface molecules having the same chemical identity as the shape recognition partner crossreact, unless the} compnse the recogmzed structural shape. Structoral shape recogmtion, shape recognition, shape recognition partner, shape recognition probe, shape-specific probe and surface ieature recogmtion refer to specific recogmtion ot a structural shape or surface ieature. Speciiically attractivity or specific attractiveness refers to a surface, structure, surface Ieature or structural shape w hich is specificalh recogmzable b} a shape-specific recognition partner, i.e., a shape-specific probe. Similarh , selected or identified surface features, shapes, structures or structural shapes (i.e . specificalh attractive surfaces or features) are surface features that can be specificalh recognized b} a shape-specific recognition partner. Specific shape recogmtion, shape-specific recogmtion and shape recogmtion refer to discnmination of one structoral shape or surface teature from another. Discnmination means binding a first surface feature and not binding a second surface feature having the same chemical composition. Perfect specificity is ideal. However, as in the case of molecular recognition (i.e., specific binding or h} bndization), a certain degree of nonspecific surface association may be expected. The practical limits on achievable discπmination with shape-specific recogmtion related to the precision of surface fabncation techniques (e.g., surface machining; molecular and atomic- scale assembh) and b} the puπty and molecule-to-molecule uniformity of shape-specific probes. Shape recognition hbranes are diverse mixtures of molecules designed or selected for screemng and/or selection of shape-specific recognition partners or templates, i.e shape- specific probes or templates. Shape-specific templates and shape recogmtion templates are biv alent or multiv alent templates compnsing at least one shape-specific probe Unlike a specific binding partner in the art-accepted use of the term, a shape recogmtion partner is capable of specificalh recogmzing a shape, texture, consistency, attribute, discontinuit} , charge distnbution, energ}, property or feature of a surface or structure rather than the chemical identity of molecules compnsing the surface or structure. A shape recogmtion partner that specificalh recognizes a structural shape or surface feature is capable of doing so without binding to other surfaces or parts of the structore, ev en other surfaces or parts having the same chemical identity as the recogmzed structural shape. In other words, shape recognition is specific for the shape and not the chemical identity of the recogmzed structure. For example, a diamondoid conical tip compnses a structural shape, if the tip (i.e., a surface feature) can be recognized by a shape recogmtion partner that does not bind a flat diamondoid face or a graphite rod. If substantial binding (i.e., crossreactivity) to a flat surface occurs, binding is not shape specific. In one exception, it may be desirable to design or select shape recognition probes that specifically recognize only flat surfaces and do not crossreact with nonflat surface features. Structural shapes may compnse, without limitation, shapes, textures, surfaces, patterns, properties or features compnsing solid supports, diamondoid structures, micromachined, micromimatonzed and nanofabncated structures, molecular devices and MOLECULAR MACHINES, molecules and groups of molecules capable of existing in at least two conformations or states, transducers, microstructures and nanostructures. Ligands and receptors may also be structural molecules or molecular effectors. A drug, for example, is both a ligand for its therapeutic receptor and an effector molecule capable of stimulating, catalyzing or mediating a therapeutic response. An enzyme which is a therapeutic target may be a receptor for a drug. As will be apparent to one of stall in the art, a molecular effector may also be transformed into a ligand or receptor, e.g., by conjugation to a ligand or receptor A molecular effector conjugated to a hgand is refened to herein as either a ligand, a molecular effector or, preferably, a molecular effector-hgand conjugate Similarly , a molecular etfector conjugated to a receptor is referred to herein as either a receptor, a molecular effector or, preferably, a molecular effector-receptor conjugate. Alternatively, by screening and selection for heretofore unknown specific binding partners, e.g., by combinatonal chemistry, in vitro evolution, directed molecular evolution and/or high-throughput screening, the identification of new compounds that speαfically bind effector molecules provides a practical means of equipping a molecular etfector with ligand or receptor properties. Specific binding refers to a measurable and reproducible degree of attraction between a ligand, receptor or defined sequence segment and a selected molecule or nucleic acid sequence. The degree of attraction need not be maximized to be optimal. Weak, moderate or strong attractions may be appropnate tor different applications The specific binding which occurs in these interactions is well known to those skilled in the art. Specific binding is saturable, noncov alent interaction between tw o species that can be competitiv ely inhibited by chemically identical or similar substances, i.e., analogs oi the binding partners. Specific binding between a ligand and receptor means affinity -based interaction related to the three-dimensional shapes of the participating molecules and does not include the hybndization of complementary nucleic acid sequences due to Watson-Cnck base painng. When used in reference to a defined sequence segment, specific binding to a selected nucleic acid sequence refers to a measurable and reproducible degree of attraction between the defined sequence segment and a selected nucleic acid sequence which may involve hybndization if participating sequences are complementan or alternative mechanisms if sequences are noncomplementary. Nonhybπdization based specific binding between noncomplementary nucleic acid sequences depends not on base painng, but on the secondary and tertian structures and charge distnbutions of participating sequences. Nucleic acid binding reactions known to involve mechanisms other than hybndization include, e.g., antisense, tπplex, quadruplex and aptamer interactions. Specific binding pairs include ligand-receptor pairs and aptamer-target pairs and do not include pairs oi hybπdized nucleotides. i.e., hybπdized, hybndizable or complementan nucleic acids or nucleic acid sequences. Molecular recognition and molecular recognition pair mean the specific molecular interactions and complexes involving either specific binding or h} bndization reactions. Different molecular recogmtion pairs means two molecular recogmtion pairs whose tour members compnse at least three different chemical identities A partner is a member of a recogmtion pair. Molecular recogmtion includes 1) specific binding between a ligand and receptor, 2) specific binding between a defined sequence segment and a nonoligonucleotide molecule, 3) specific binding between defined sequence segments and/or selected nucleic acid sequences, and 4) h} bndization between complementan nucleic acid sequences and/or defined sequence segments. Molecular recognition does not include specific surface attractivit} or shape-specific recognition of a specificalh attractiv e surface feature. Catalytic recognition refers to the selective interactions between enz}mes, catahst and their substrates, inhibitors and cofactors. Recognition reters to all forms of recognition disclosed in the instant application, including molecular recogmtion, structural shape recogmtion, catahtic recognition and specific attracti ity. Probes are specific recognition elements, i.e , recognition partners capable of specifically recognizing a selected target wherein the target compnses a nucleotide or nonnucleotide molecule or a structural shape. Templates are MOLECULAR MACHINES compnsing at least one probe. Probes compnsing MOLECULAR MACHINES of the instant invention are capable of specific recognition, i.e., specific binding, hybndization or shape-specific recognition. MOLECULAR MACHINES are also capable ot catahtic recognition, e.g., v ia nucleotide catahst, h}bndιzed or specificalh bound catahtic nucleotides and speciiicalh attached selected molecules. Recognition, w hen used in reference to a MOLECULAR MACHINE, refers to specific recognition or, as the case ma} be, catahtic recognition (i.e., specific binding, h} bndization, structural shape recognition or catalytic recognition). MOLECULAR MACHINES, templates, recogmtion partners and probes of the instant invention may be targeted, deliv ered, attracted and bound b} specific recogmtion of surface features (i.e., structural shapes) as well as art-accepted specific binding and h} bndization modalities). Converseh , surfaces ma} be recognized, probed, targeted, modified, bound and bonded by the structural shape recogmtion properties of the instant MOLECULAR MACHINES. MOLECULAR MACHINE and MOLECULAR MACHINES include methods and dev ices of the instant invention, e.g., nucleotide-based and plastic segments and templates, paired selected molecules, templates, hbranes, processes, devices and systems, functionally coupled selected molecules, templates, libranes, processes, devices and systems, paired specific recognition dev ices, designer drugs, smaRTdrugs, shape recognition probes, shape recogmtion hbranes, bivalent and multivalent templates, shape recognition templates, specificalh attractive surfaces, surface feature hbranes, multimolecular dev ices, tethered specific recognition devices, molecular adhesives, molecular adherents, molecular adsorbents, molecular lubncants, promolecular deliver} dev ices, any of these dev ices, libranes or surfaces in combination, and particularly a MOLECULAR MACHINE operativ ely attached to a surface and or informational de ice, particularly a transducer surface and/ or informational system, particularly operative attachment compnsing functional coupling. Paired specific recognition pairs and paired specific recognition dev ices are molecules, molecular scaffolds or multimolecular structures compnsing at least two specific recognition pairs, each pair compnsing two specific recogmtion partners. Specific recogmtion partners, i.e., members ot a specific recognition pair, include nucleotide and nonnucleotide molecules and groups of molecules, including nucleotides, modified nucleotides. nucleotide analogs, nucleotide ligands, nucleotide receptors, deiined sequence segments, nucleotide spacers, linker oligonucleotides, selected nucleic acid sequences, nonnucleotide linkers, selected molecules and molecular scaf folds. Specific recognition partners may be capable of specifically binding, hybndizing or shape-specif ic recogmtion. Paired specific recognition devices include nucleotide-based and nonnucleotide multimolecular devices, tethered specific recogmtion dev ices, multimolecular adhesives, multimolecular adherents, targeted promolecular delivery devices, aptamenc devices and mapping hbranes capable of either 1) detecting, isolating, identifying or transposing matter, energy , data or information or 2) exchanging matter, energy , data or information between two molecules or groups of molecules, between two systems or subsystems, or between a system or subsystem and its env ironment, including, but not limited to. informational devices, sw itches, sensors, transducers, actuators, molecular deliv ery sy stems, drug deliv ery sy stems, adhesiv e dev ices, adherent dev ices, soluble molecular complexes and assemblies, aptamenc dev ices, structural shape recognition probes and mapping hbranes. In a prefened embodiment ot the instant invention, template -directed assembly may be used to produce a promolecular delivery device compnsing a payload molecule(s) specifically bound in inactive, quasirev ersible, releasable and/or activ atable form to a designer receptor (as distinct from a target receptor, targeted receptor or disease target). The promolecular deliv ery device is capable of binding, stoπng, presening, stabilizing, transporting, dehvenng, releasing and/or attaching the payload molecule in such manner that dev ice binding to a selected target v la a second recognition site (i.e., a targeting site) results in delivery, concentration, localization, release and or activation of payload molecule(s) at a desired site of action (e.g., a selected molecule or selected nucleic acid sequence compnsing a pollutant, contaminant, plant pathogen, biological weapon, toxic chemical, oil spill, microbe, v mis, disease marker, or therapeutic receptor). The payload molecule is bound to a first molecular recogmtion or shape recogmtion site (i.e., a designer receptor) of the promolecular dehv e dev ice template in inactive and/or unavailable form. The resulting promolecule complex (i.e., payload-designer receptor complex) is analogous to a prodrug complex compnsing a drug bound in inacti e form to a designer receptor selected to bind and occupy the active site of the drug. The difference is that a promolecule complex may compnse as payload molecule not only a drug, but any nucleotide or nonnucleotide molecule or structural shape (e.g., a surface feature compnsing a buckyball, nanotobe or nanorod) which is capable of performing a useful function when deliv ered to a selected target. The payload is preferably a selected molecule (e.g., a ligand. structoral molecule or effector molecule) or a selected nucleic acid sequence (e.g., an aptamer, πbozyme, antisense or tnplex-forming nucleotide). The second, optionally allostenc, specific recognition site compnsing a promolecular dehvery device is responsible for dehvenng and/or releasing the payload molecule(s) to selected molecules or selected nucleic acid sequences compnsing, attaching or neighboπng a selected target. In a prefened mode ot operation, the designer receptor is a relatively low affinity or low av ldity target-mimetic receptor that competes with a higher affinity target for binding of the payload molecule. When brought w I thin close spatial proximity of the selected target, e.g., by allostenc targeting, the payload molecule preferentially dissociates f rom the lower affinity designer receptor and binds to the higher affinity target recognition site. In a particularly prefened embodiment, binding of the allostenc recognition site influences the binding or activity of the payload molecule at the designer receptor site by a second (i.e., allostenc) mechamsm. In the allostenc mode, binding of the target recogmtion site to the selected target facilitates, enables or accelerates the dissociation of the payload molecule from the designer receptor. This prefened aspect of promolecular dehv ery compnses three distinct and additive, preferably synergistic, mechanisms. First, the payload molecule is ad antageously partitioned or titrated between a high capacity -low affinity designer receptor and a high atfimty target recognition site, the target optionally being present at v ery low concentration. Second, pay load delivery is site-directed, i.e., specifically directed to the target by means of a target-specific recognition site. Third, local deliv ery of the payload to the target recognition site is accelerated or facilitated by the allostenc tnggered release mechanism In another preferred mode ot operation, the payload molecule is also tethered to a molecular scaffold compnsing the designer receptor, prov iding a tethered molecular delivery dev ice, i.e., a tethered dev ice. In this aspect, the payload molecule is not only specifically attached, but also pseudoirreversibly or covalently attached (i.e., tethered) to the designer receptor. In another preferred mode of operation, the rev ersible activation (i.e., repeat- action) potential of tethered specific recogmtion devices (vide infra) is used in a "detect-and- actuate" or "search-and-destroy " mode, e.g., for defense, detoxification, environmental remediation, and agπceutical (e.g., fertilizers, vaccines and pesticides), cosmeceutical, nutraceutical and pharmaceutical molecular delivery applications. For example, a tethered specific recognition device comprising a prodrug that is rev ersibly and repeatedly activated and inactivated in response to sequential target binding is configured as follows. A payload molecule comprising a therapeutic enzyme is tethered (via a linear and flexible molecular scaffold preferably less than about 100 nm in length) and specifically bound in inactivated form to a first molecular recognition site comprising a selected inhibitory ligand. A second molecular recogmtion site (i.e., a targeting ligand selected for high-affinity specific binding to the substrate (i.e., target) of the therapeutic enzyme) is positioned within the loop region between the inhibitory ligand and the therapeutic enzyme to which the inhibitory ligand is bound. The targeting ligand is located toward the inhibitory ligand end of the molecular scaffold in close proximity to the tethered, specifically bound inhibitory ligand-therapeutic enzyme complex, preferably within about 10 nm of the bound inhibitory ligand and more preferably within about one nanometer of the bound inhibitory ligand. Binding of the high- affinity targeting ligand to its receptor (i.e., the therapeutic target) dissociates the inhibitory ligand-therapeutic enzyme complex, resulting in activation of the therapeutic enzyme. The activated therapeutic enzyme catalyzes the cleavage, modification, digestion and/or degradation of its substrate (i.e., the receptor of the targeting ligand). Modification of the targeting ligand's receptor (i.e., the therapeutic enzyme substrate) causes, facilitates or accelerates ligand-receptor dissociation, freeing the targeting ligand. With the targeting ligand in the free state, the tethered recognition device switches back to the inhibited state (i.e., the tethered inhibitory ligand rebinds and inhibits the therapeutic enzyme), resetting the device for another search-and-destroy cycle. The choice of molecular scaffold for this type of reversible, autocatalytic device depends on the environment in which it is to be used. For in vivo, topical and extracorporeal applications (e.g., prodrug delivery, detoxification, dynamic imaging), the choice of molecular scaffold composition is limited to biological or biocompatible molecules, polymers, microstructures and nanostructures comprising, e.g., nucleotides, peptides, carbohydrates, lipids, dendrimers, surfactants, organic hydrocarbons and polyamines; implantable, injectible and bioerodible polymers, particularly imprint polymers, copolymers and heteropolymers; and bifunctional, trifunctional and multifunctional molecules, particularly heterofunctional, heterobifunctional and heterotrifunctional molecules and groups of molecules. For environmental, military, agricultural and industrial applications (e.g., ground, water and site remediation, chemical and biological defense) important attributes include durability and/or biodegradability, safety, scalability and cost. Flexible, durable, well-defined and inexpensive synthetic polymers, bifunctional and heterofunctional molecules are particularly suitable, particularly copolymers and heteropolymers, preferably flexible and/or looped, bent, hinged, branched, circular or polygonal polymers that Can be designed and manufactured with controlled topology and/or precision joints, hinges, bends or branchpoints, and more preferably polymers amenable to imprinting and/or reproducible, site-directed attachment of selected molecules. In another prefened mode of operation, the bond(s) used to tether the payload molecule to the designer receptor (i.e., scaftold) is both pseudoineversible, optionally covalent, and willfully or environmentally reversible. The tethenng bond(s) may be cleavable, tor instance and without limitation, by chemical, photochemical, thermal, enzymatic or lomc means, including laser-dnven and photodynamic and hyperthermic modalities. In a particularly prefened embodiment, cleavage is mediated by a selected condition or substance which is relativ ely specific for or localized to the selected target. Cleavage and tnggered release may be catalyzed, for example, by a particular hazardous waste substance at a bioremediation site; or accumulation ot a pesticide residue in an agncultural setting; or a particular excreted solute or analyte absorbed by a transdermal drug dehv ery sy stem (e.g., a patch); or a biological or chemical w arfare agent Where the payload molecule is a drug, the tirst specific recognition pair is refened to as a prodrug complex or drug-receptor complex. Promolecular effector complexes of the invention (i.e , a promolecule being analogous to a prodrug) include not only prodrug complexes, but also prosignal -generating species complexes compnsing specifically bound tags, tracers, radioisotopes, labels, reporters, polymers, hght-hanesting structures, antennae, photonic assemblies, photosynthetic molecules, macromolecules, microparticles, nanoparticles, colloids, metals, dyes, fluorophores, phosphors, photosensitive molecules, metabolic, signal transduction and photosystem molecules, reaction centers, enzymes, coenzymes, cofactors, catalytic antibodies, molecular mimics, biomimetics, luminescent, tnboluminescent, sonoluminescent, chemiluminescent, bioluminescent and electroluminescent molecules, electron transter donors and acceptors, oxidizing and reducing compounds, mediators, and the like. In a particularly preterred designer drug embodiment (i.e., smaRTdrugs), the combination oi drug-de ice tethenng and prodrug complex-based partitioning provides a fourth and tailsaie level ot specificity tor maximal saiety and efficacy of the targeted, partitioned, tnggered-release therapeutic device. Target specificity is achiev ed by the additive and preferably synergistic combination of 1) site-specific targeting, and 2) affinity partitioning between designer receptor and target, and 3) allostenc tnggered-release mechamsms. and further 4) localized enzymatic, metabolic or cot actor-dependent cleavage of the prodrug tether This fourth level of target selectiv ity is achieved by a molecular effector (e.g.. an enzyme, metabolite, pathophysiologic event or willfully or endogenously supplied cofactor) which is relatively site-localized (e.g., infection, inflammation, cancer) or disease-dependent (e.g., cancer, diabetes, cinhosis atherosclerosis). Prodrug complex means a prodrug compnsing at least two noncovalently bound molecules and includes, preferabh a drug specifically bound to a designer receptor wherein the designer receptor mimics the specificity of a therapeutic target for a drug. Prodrug complexes may also compnse a pair or plurality of drugs specifically bound to a pair or plurality of designer receptors. Prodrug complexes may also be operatively attached to biological or biocompatible microstructures or nanostructures free to distπbute in one or more physiological compartments. Alternatively, prodrug complexes may attach to solid tissues or anatomically confined biologic or biocompatible structures, or they may be willfully attached to cells, tissues or organs, optionally reversibly or by a willfully biodegradable, cleavable and/or metabohzable linkage. Prodrug complexes may be stored, confined or released in a selected physiological or anatomical compartments or, alternatively, transported, delivered and or confined to a selected physiological or anatomical compartment, site or target. Designer receptor, selected receptor and synthetic receptor mean any naturally occurnng, recombinant, biological, biologically produced or synthetic nucleotide or nonnucleotide molecule or group oi molecules compnsing a specific recogmtion partner selected from the group consisting ot specific binding partners, hybndizable nucleic acid sequences, shape recognition partners, specifically attractive surfaces or a catalytic recognition partner selected from the group consisting ot enzymes, catalysts, biological recognition sites, biomimetics, enzyme mimetics and molecules participating in catalytic recogmtion reactions. Adv antageously , designer receptors compnsing multimolecular drug delivery systems of the instant invention are selected for the ability specifically recogmze a drug or therapeutic receptor, optionally to mimic the specificity of a therapeutic receptor for a drug. Catalytic recogmtion partner means a natural or synthetic substance participating in a selectiv e catalytic or enzymatic reaction and includes protein and nonprotein enzymes and catalysts; nucleotide and nonnucleotide enzymes and catalysts; organic and inorgamc enzymes and catalysts, specific, selective, class-specific and class-selectiv e enzymes and catalysts; and mimetics and impnnts and conjugates of any ot these molecules. Molecules participating in catalytic reactions include substrates, products, intermediates, coenzymes, cofactors. prosthetic groups, regulatory factors, steπc and allostenc modulators, inhibitors, mediators, and the like. Promolecular delivery dev ices are also paired recogmtion dev ices as will be apparent from the following general descnption. A first specific recognition pair compnses a designer receptor capable ot specifically recognizing, stonng or transporting a selected molecule, preferably an efiector molecule in inactiv e or unavailable torm. An attached second specific recognition pair compnses a targeting and/or release-tπggeπng first member (i.e., a ligand. receptor, defined sequence segment or shape-specific probe) that specifically recognizes a second member (i.e., recognition partner) that compnses a site at, on or near an identified (i.e., selected) target. On binding oi the targeting first member of the second specific recogmtion pair at the target site, the selected (preferably inactive effector) molecule releases and or attaches to the selected target. The released and or targeted selected molecule is thereby made actively av ailable to the selected target, generating or causing to be generated a desired effect (e.g., modification of the selected target). Informational device means a synthetic dev ice, product, medium, machine, program, code, process, library, database or means for marking, displaying, conveying, representing, mapping, transposing, impnnting, embodying, stonng, replicating, archiving, companng, analyzing, searching, researching, or transmitting data, information or instructions, particularly including molecular modeling, biocomputing, multifactoπal search engines and hardware and software designed for ultrafast, ultrapowerful mapping, transposing, companng, integrating, inteφreting, intenogating, modeling and simulating molecular sequence, structure, shape, docking, dynamics, quantitative structure-activity relationships (QSAR). Informational system means a pair of functionally coupled informational devices. Functionally coupled informational dev ices ot the inv ention are capable ot lteratively expanding the domain of informational space comprehended by either device and/or the paired dev ices, i.e., evolving, if the informational system is functionally coupled to a second system, i.e.. a source of information, preierably an evolv ing source of information. The source of information may be natural, biological or synthetic. For puφoses of the instant invention, the source of information is preierably willful, i.e., provided or mediated by humans. Willful functional coupling between information source and sink (i.e., processor) adv antageoush' includes human-directed and/or human-supen lsed direct functional coupling between an information source (e.g., nature) and an informational system (e.g., paired search engines). Evolution, when used in reference to paired informational devices of the instant inv ention, means learning. Machine learning, machine-directed and machine- intelligence refer to products and processes enabled, facilitated or accelerated by informational dev ices, particularly paired informational dev ices compnsing informational systems, more preferably informational systems compnsing, attaching to, or capable ot attaching to learning machines, e.g., evolv ing expert systems and intelligent machines. Intelligent means capable of learning. When used in reierence to learning tor willful puφose(s), intelligence requires either a functionally coupled system compnsing an informational device and a human and/or humanly introduced information source or a functionally coupled paired informational dev ice compnsing or connecting to an external information source. Learning, when used in reference to an informational devιce(s) or system(s), means that the domain of informational space (i.e., knowledge) comprehended by the devιce(s) or system(s) expands with time as a function of the expanding domain encompassed by that which is heretofore known at a giv en point in time (i.e., all present knowledge). Functional coupling between the machine-comprehended domain (i.e., machine domain) and the informational source domain (i.e., information source) may be tight and efficient in time and space, or functional coupling may be loose and inefficient. In perfectly tight and efficient functional coupling between paired informational devιce(s) (i.e., an informational system) and an information source, the source information is instantiv available (i.e., immediately known) to the informational system. Perfect functional coupling is unattainable, as incoming source information must be added to, integrated, compared with and combinatoπally permuted against ιts(new)self, The process of achieving the new, higher order informational state (i.e., knowledge) compnsing ιts(new)self requires finite processing time, i.e., the time required for added information to be adopted, archived and combinatonally internally permuted, thereby forming a higher order information state which must ιts(new )self be combinatonally internally permuted, and so forth. Even assuming instantaneous (i.e., timeless) communication between information source and informational devιce(s) (i.e., sink), functional coupling efficiency between source and sink is limited by the internal processing time of the informational devιce(s). Molecular search engine and search engine, w hen used in reference to molecular div ersity , div ersity space, molecular space, shape space, structoral space, surface space, chemical space, catalytic space, surface attractivity space, positional space, means at least one member ot a set ot networked, massively parallel lniormational systems compnsing pairs of paired informational devices compnsing paired processors compnsing paired switches. Advantageously, the informational system architecture compnses paired pairs oi devices compnsing processors compnsing switches, e.g., (pairs oi paired informational each processor compnsing (pairs of paired switches)^, each sw itch being advantageously binary. Processing speed is a function of degree of parallelism, e.g., number of processors per system. A first-generation search engine compnsing a one-dimensional linear systolic array with 364,000 on-board processors operating in parallel has been designed for this purpose. Alternative processor architectures comprising anays with two-dimensional and three-dimensional connectivity are presently under consideration. The operative informational system advantageously compnses a first molecular search engine (i.e.. molecular knowledge base) that encompasses, archives and provides access to information regarding the evolving set of heretofore known and emerging (i.e.. knowable and discoverable) molecules as well as structural shapes and surface features compnsing matenals. A second application-specific and functionally coupled search engine encompasses, e.g., the relationship among chemical identity , structure, shape and function of newly discovered selected molecules and matenals. A third application-specific and functionally coupled search engine encompasses, e.g., the evolving domain of useful applications for heretofore known and unknown matenals and molecules. A fourth application-specific and functionally coupled search engine encompasses, e.g., the relationship between structorofunctional properties of newly discovered (as well as heretofore known) selected molecules/mateπals and the evolving domain of useful applications for such known and unknown matenals/molecules. A fifth application-specific and functionally coupled search engine generates hypotheses regarding the intersection between commercially useful applications and properties/activ lties of mateπal/molecules. A sixth application-specific and functionally coupled search engine tests the hypotheses generated by the fifth search engine, and so forth. Networked means functionally coupled machines capable of generating and testing hypotheses with timely and efficient access to an evolving collective knowledge base compnsing application specific evolving knowledge bases. Matenals, selected matenals and identified matenals, when used in reference to a molecular knowledge base and/or search for new matenals, refer to structures, structural shapes, surfaces and surface features compnsing selected molecules, as distinct from the selected molecules themselves. This distinction is made for claπty to enable well -articulated searches tor selected molecules capable of interacting with structures, structural shapes, surfaces and surface features and, conversely, intelligent searches for structures, structural shapes, surfaces and surface features capable of specifically interacting with selected molecules. In general, structures, structural shapes, surfaces and surface features may be v lewed as solid structures and surfaces as a conceptual guide. Selected molecules, on the other hand, may be viewed as mobile for conceptual purposes, wherein mobility does not imply anything definitional regarding the size, solubility, dispersion, solute, solvent or colhgative properties or characteπstics, particulateness, autonomy, three-dimensional structure or architecture of a selected molecule. The distinction between selected molecules and selected matenals is also made to elaborate and underscore a central premise and inventive step disclosed herein, that matenals compnsing structural shapes and surface features are capable of specifically recognizing selected molecules independent of the chemical composition of the molecules compnsing the structoral shapes and surfaces. This premise denves from the following seminal, albeit modest, insight: As technologies emerge to enable precision manufactunng at the submicron scale, preierably nanometer and subnanometer scale, heretofore unappreciated specific recogmtion and catalytic properties of matter will emerge withm chemically bland matenals as a consequence oi newly selected and designed three dimensional shapes at molecular scale. In other words, heretofore chemically bland matenals will become plastic and personable with respect to interactions with compositionallv diverse molecules refened to herein as selected molecules. So the distinction between selected matenals and selected molecules relates to the transposition of structures and surfaces heretofore used as chemically passive into matenals with diverse and useful recognition properties. Nanofabncation, nanomanipulation and molecular-scale sculpting of inorganic (as well as orgamc) substrates enables the conversion or transformation of passive, bulk matenals into usefully active (i.e., reactive) matenals. The emerging activities of chemically bland (e.g., monolithic, elementally pure, homogeneous, structurally uniform, amoφhous, or specifically unrecognizable) matenals will resemble and complement the specific binding and catalytic recogmtion properties heretofore understood and applied only in respect of the chemical composition of selected molecules. Coupling inefficiencies anse from imperfect sensitivity or receptiveness to input data (i.e., inaccessible or unrecognizable data or information), temporal lags (i.e., delays in reception, sluggish processing), noise (i.e., nonsense) and contamination (i.e.. distortion, misinformation), disadvantageously accompanied by destructive interactions (e.g., negative synergy, negative cooperativity, cooperativity in a negative direction, competition and/or unresolved conflict). Tight coupling and efficient coupling, when used in reference to the functional coupling of machine intelligence to a process, domain or system, means that data and or information are effectively comprehended in a usefully timely manner. Informational devices of the inv ention particularly include high-order paired search engines compnsing massively parallel processors, switching and software capabilities for transposing molecular structure-activity space and surface attractivity space, i.e., structure- activ ity -surface space (SASS), into informational space. Contemplated herein are multiply networked anays of parallel processors with adequate computing power to engage in a w illfully automatable, self-sustaining, closed-loop feedback system compnsing an lniormational search engine functionally coupled to a molecular diversity generator. The molecular div ersity generator is designed to express and explore vast regions of structure- activ ιty space by generating and evolv ing polydiv erse libranes of libranes, preferabh paired nucleotide and nonnucleotide libranes operating in a div ergent, self-sustaining nucleotide- nonnucleotide cycle of impnnting impnnts. In a preferred mode of operation, the molecular diversity generator and informational search engine are tightly coupled and fully automated, albeit willfully directed. Instructions include written or nonwntten letters, words, numbers or numerals, recordings, replicas, representations or facsimiles, pictures, signs, symbols, digital or analog data or code, static or dynamic images, audio, visual, tactile, olfactory or other sensory , perceptible or inteφretable messages, data or information. Detection, deciphenng, decoding, deconv olution or inteφretation oi instructions may be accomplished by sensory means, or. alternatively , may require suitable instrumentation, e.g., a light source, laser, scanner, reader, detector, sensor, transducer, amplifier, magnifier, decoder, microphone, recorder, transmitter, imaging system or the like. Aptamers and aptamer targets as used herein are distinguished from ligands and receptors. Although an aptamer and its target are specific binding partners and members of a specific binding pair, they are not refened to herein as ligands and receptors. The inventor's lexicography in this regard is intended to avoid confusion ansing from overlapping pπor art usage of the terms ligand and receptor with respect to aptamers. Nucleic acid ligands, nucleic acid receptors, nucleic acid antibodies and aptamers are commonly descnbed in the art w ithout definition. The synthetic heteropolymers of the present invention allow for the production ot ordered pairs, groups and anays of selected nonoligonucleotide molecules, preferably receptors, ligands or effector molecules, whose cooperative interactions have utility in diagnostics, therapeutics, bioprocessing, microelectronics, energy transduction and, more generally, molecular manufactunng. Cooperating, cooperativ e interactions and cooperativity refer either to the ability of selected molecules to interact positively or negatively to produce a desired result or to an effect on one molecule created by the presence of a second molecule or to an action or effect brought about by the proximity of tvv o or more molecules or to the combined actions of two or more molecules on a third molecule or to a chemical, electncal, optical, thermal, mechanical, energetic or informational transformation involving two or more molecules. This invention enables preparation of ordered pairs, groups or arrays of selected biological or nonbiological molecules that i unction in a concerted manner to transduce energy or perform useful work. Whereas biological systems rely on membranes, molecular chaperones and self-assembling systems to create ordered anangements of proteins, hpids and glycoconjugates as ion channels, effector-coupled membrane receptors, biochemical amplifiers and metabolic pathways, the present invention teaches methods to create multimolecular machines using selected, designed or engineered nucleotides as molecular ordenng devices, i.e., molecular scaffolds or multisite templates. Nucleotide- based templates may be heteropolymenc, aptamenc or nonaptamenc. They may be synthesized by biological, chemical and/or enzymatic methods known in the art, including manual and automated methods, clomng, transcπption, replication and/or amplification, optionally including willful infidelity and/or directed evolution. Cooperativity includes but is not limited to functional coupling between or among two or more molecules, reactions or processes. Functional coupling and functionally coupled mean that at least two processes are connected by a common reaction, event or intermediate or that at least two compositions, which may be molecules, species, substances, structures, devices, groups or combinations thereof, participate as donor and acceptor in the transfer of mass (e.g., molecules, atoms or subatomic particles) or energy (e.g., photons, electrons or chemical or mechanical or thermal energy), or that two processes or compositions act on a third process, composition, disease or condition in an additive, partially additive or subtractive, mutuahstic, synergistic, combined or interdependent manner. Examples of such coupling are well known in the art, e.g., Gust et al. ( 1993) Accounts of Chemical Research 26: 198-205; Sheeler, P. and Bianchi, D.E. (1983) Cell Biology: Structure, Biochemistry, and Function, p. 203, John Wiley & Sons, Inc., New York; Saier, H.S. Jr. (1987), Enzymes in Metabolic Pathways: A comparative Study of Mechanism, Structure, Evolution, and Control, pp. 48-59 and 132-136, Harper & Row Publishers, New York; Aidley D.J. (1989), The Physiology of Excitable Cells, Third Edition, p. 320, Cambπdge University Press, Cambridge; Bray, H.G. and White, K. (1957), Kinetics and Thermodynamics in Biochemistry, p. 135, Academic Press, New York; and Guyton, AC (1971) Textbook of Medical Physiology, Fourth Edition, p. 786, W.B. Saunders Company, Philadelphia). When used in reference to the interaction between two specific recognition pairs, functional coupling and functionally coupled mean that the binding or activity of a member of a first specific recogmtion pair influences the binding or acti ity of a member of a second specific recogmtion pair or that members of both specific recogmtion pairs bind to or act upon a common substance, disease, condition or process in an additive, partially additive, or cooperative manner. Members of both specific recogmtion pairs bind to or act upon a common disease or condition, for example, when two (or more) functionally coupled drugs and/or targeting agents act in a combined, additive or synergistic manner at a single disease target or at two or more localized receptors. Nucleotide-based multimolecular delivery devices of the instant invention compnse at least two specific recognition pairs functionally coupled in this manner to dehv er. target and/or release selected molecules and/or selected nucleic acid sequences to selected targets (e.g., therapeutic receptors, environmental, agncultural or food contaminants, pests, or pathogens, chemical or biological weaponry, selected sites, receptors or featores compnsing molecular arrays, biochips or micromimatunzed devices) When used in reference to single-molecule detection, functional coupling means to enable detection of an indiv idual complex compnsing a pair or group oi molecules attached by nucleotides oi, alternatively, to enable discnmination of an individual complex compnsing a pair or group ot molecules attached by nucleotides trom an uncomplexed molecule or plurality ot molecules Nucleotide-based templates and/or multimolecular dev ices of the instant invention can also se e as molecular delivery devices by positiomng selected molecules without functional coupling between the selected molecules. Selected molecules compnsing structural molecules can, for instance, be positioned to prov ide a useful function which results from a microscopic or macroscopic structural effect, e.g., adhesion between two surfaces, attachment of a selected molecule to a nanostructural shape (e.g., an edge, lip or corner) or strengthemng, lengthening, thickening, protecting or coloπng an eyelash, eyebro , nail or hair In one embodiment, bivalent or multivalent nucleotide-based templates, preferably one or multiple defined sequence segments compnsing at least two specific binding or shape recognition pairs, optionally at least one specific binding or shape recogmtion pair plus one pair of hybndizable nucleotide sequences, are designed for use as adhesives Adhesives may be used, e.g.. for assembling, attaching, pactang and sealing parts, products, packages and packing matenals, e.g., by bonding two amphibious surfaces together They may also be used to specifically bind or hybndize a selected molecule to an amphibious surface. For example, cosmetic adhesives disclosed herein may be used to speciiically bind or hybndize eyeliners, thickeners and lengtheners eyelashes and eyebrows or, alternatively, polishes and strengthemng agents to fingernails and toenails. When used in reference to multimolecular adhesive attachment, surface means an amphibious surface. Amphibious surfaces are either able to operate on land, in air, in vacuum, or in fluids including, but not limited to, gaseous, liquid, aqueous and organic solutions and suspensions or in some combination of these environments They are not reagent-binding or analyte-bmding separation matnces of specific binding assays or nucleic acid hy bndization assays A surface is a boundary in tw o-dimensional or three-dimensional space Adhesives of the instant inv ention are optionally user-responsiv e or environment- responsiv e, meamng that after application of adhesiv e(s) to amphibious surface(s), the surface-bonding (i.e.. adhesiv e) f unction can be w lllfully or env ironmentally tnggered (i.e., initiated) by a first selected associative stimulus (l e , an adhesiv e or bonding stimulus) Selected bonding stimuli include, for instance and w ithout limitation, changes in ambient temperature, pressure, humidity or light exposure, the w illful input or exchange of energy (e.g , laser light, photons, darkness, sound, heat, cold, electromagnetic radiation), or application or removal of a selected nonoligonucleotide molecule (e g., a solv ent, solute, ligand, receptor or effector molecule) or ohgonucleotide (e g , a linker ohgonucleotide, aptamer or hybndizable defined sequence segment) The adhesiv es are also optionally rev ersible, preferably w illfully or env ironmentally rev ersible, meaning that bonding can be reversed in response to a iirst dissociativ e selected stimulus (I e., an unbondmg or antiadhesiv e stimulus) Unbondmg stimuli include, tor instance and w ithout limitation, changes in ambient temperature, pressure, humidity or light exposure and/or the willful input or exchange of energy , or application or remov al ot a selected nonoligonucleotide molecule or ohgonucleotide The unbondmg stimulus may be the remov al, absence or disappearance of the bonding stimulus (e.g., cooling, darkness, wetness or dryness). Alternati ely, the unbondmg stimulus may not be substantiveh different from the bonding stimulus (e g., use oi a solv ent to unbond light-induced adhesion) Follow ing unbondmg, adhesion may optionally be restored, preferably by a second bonding stimulus and advantageously a repetition ot the first bonding stimulus In bonded torm, adhesiv es ot the instant inv ention compnse at least a bivalent molecule or scaffold compnsing at least two specific recognition pairs, at least one specific recognition pair being a specific binding or shape recognition pair A first selected molecule, preferably a structural molecule and optionally a structural shape comprising a first amphibious surface, is speciiically bound and optionally cov alently ciosshnked to a first specific recognition site ot the molecule or scaffold, optionally a discrete structore compnsing a synthetic heteropolymer. A second selected molecule, preferably a structural molecule and optionally a structural shape compnsing a second amphibious surface, is specifically bound or hybndized (i.e., via a conjugated ohgonucleotide) to the second specific recognition site of the molecule or scaffold, optionally cov alently crosshnked in place following specific binding or hybndization to the molecule or scaffold. In unbonded form, adhesiv es compnse at least a bivalent molecule or scaffold compnsing at least two specific recognition sites, at least one specific recognition site being a ligand, receptor or a defined sequence segment compnsing an aptamer. An adhesive synthetic heteropolymer, for example, compnses. a first defined sequence segment capable ot specifically binding a first structoral molecule of a first amphibious surface, edge or part and a second defined sequence segment capable oi either specifically binding a second structoral molecule of a second amphibious surface or of hybndizing to an immobilized or linker ohgonucleotide. A second adhesive synthetic heteropolymer and or immobilized ohgonucleotide may be applied to or attached to the second amphibious surface. A diverse anay of different molecular adhesive compositions is possible using nucleotide-based and nonnucleotide templates. Synthetic heteropolymers, multivalent heteropolymenc hybnd structures, aptamenc compositions, and modified nucleotides compnsing single or multiple deiined sequence segments can bond surfaces by different permutations of specific binding, structural shape recognition and hybndization. Plastic templates can bond surfaces by specific binding or structural shape recognition. Different molecular adhesive formulations may be applied either to a first surface or to a second surface or to both surfaces to be bonded Multimolecular adhesives. i.e., molecular adhesives. are molecular bonding or attaching devices compnsing at least a bivalent molecule or scaffold ha ing at least two specific recognition sites, at least one being capable of specifically recogmzing a selected molecule and at least one being capable of specifically binding or hybndizing to an amphibious surface. When used in reference to multimolecular adhesiv e attachment, surface means amphibious surface. At least one specific recognition site is capable of specifically binding to a first selected molecule, optionally a structural molecule and advantageously a first structoral shape compnsing a first surface. The other specific recogmtion site is capable of specifically binding to a second selected molecule, advantageously a second structural shape compnsing a second surface, or of hybndizing to a selected nucleic acid sequence. The selected nucleic acid sequence is preferably immobilized or capable of attaching to a solid support, optionally an ohgonucleotide, conjugated ohgonucleotide, linker ohgonucleotide, defined sequence segment or a synthetic heteropolymer. The selected nucleic acid sequence may be immobilized or capable ot attaching to the second surface or to a third surface capable oi attaching to the second surface, e.g., a mieroparticle or nanoparticle, matnx, layer, membrane, gel, foam, nanostructure or microstructure The second selected molecule, which may be a ligand, receptor, effector or structoral molecule, may advantageously be a structural shape on the second surface which does not occur on the first surface. In this way, a bivalent multimolecular adhesive compnsing a first structural shape speαfically bound to a first specific binding site and a second structural shape specifically bound to a second specific binding site of a molecule or scaffold can be used to specifically and reversibly bond two surfaces having the same chemical composition. Unlike conventional glues and adhesives, the multimolecular adhesive is specifically onented, polanzed or sided with respect to the two surfaces, enabling precise titration and control of adhesive force between the bonded surfaces. In addition, a bivalent multimolecular adhesive that specifically binds and attaches a first structoral shape on a first surface and a second structural shape on a second surface provides an entirely nov el and commercially v aluable method for attaching nanometer-scale features on the two surfaces in register. In a prefened embodiment, multimolecular adhesiv es are designed for use in industnal environments, e.g., for alignment and specific attachment of nanoscale features compnsing micromachined surfaces, e.g., physical and chemical sensors, semiconductors, microelectromechanical systems (MEMS) and MEMS devices, nanoelectromechanical systems (NEMS) and NEMS devices and ultrafast molecular computers. Because mdustnal- use MEMS and NEMS devices and associated sensor, actuator and transducer surfaces represent extremely harsh and unforgiving env ironments, nucleotide ligands, nucleotide receptors, aptamers and hybndizable nucleotides are prefened, even required, over more readily av ailable ligands and receptors (e.g., antigens, antibodies, av idin, streptavidin, lectins, drug and hormone receptors), and receptors and are prefened over specific recognition Protein-based antibodies and receptors cunently used in diagnostic and analytical specific binding assays are not sufficiently robust to function for protracted inte als under the extreme and v olatile thermal, chemical and electromechanical conditions operativ e dunng MEMS manufacture and use. A bivalent heteropolymenc multimolecular adhesive is prepared as follows for precise feature-to-feature bonding of silicon-etched first and second amphibious surfaces comprising a hybnd memory device. A first convex tip of the first surface and second concav e pit of the second surface, each having specifically attractive surface features (i.e., a recognizable v ertex and nadir, respectively) are refened to as male and female surfaces. The first (i.e , male) amphibious surface compnses a tip feature which is a nanometer-scale vertex (i.e., first feature) of a solid, convex, conical tip on a silicon semiconductor. The conical tip has a height of about two microns and a base diameter of about two microns. The second amphibious surface compnses a concav e, conical pit about two microns in diameter at the base (i.e., surface) and about two microns deep at the nadir (i.e., second feature). For selection ot template recogmtion elements, an array of conesponding tip vertex and pit nadir features is micromachined into a single silicon surface by a combination of lithographic and chemical etching techniques well known in the art. A diverse nucleic acid library compnsing random-sequence single-stranded nucleotides (with fixed pnmer-annealing sequences) labeled to high specific activity with rhodamine is screened and selected for a first defined sequence segment capable of specifically recognizing the first surface feature (i.e., conical tip v ertex) and a second defined sequence segment capable of specifically recognizing the second surface feature (i.e., concave pit nadir) in a selected solvent system. Counterselection is performed using unmachined and polished silicon wafers. Specific recognition of rhodamine-labeled nucleotides to first and second surface featores is detected by continuous wave laser excitation with fluorescence detection (e.g., Soper et al. (1991) Anal. Chem. 63:432-437) coupled with AFM. Surface feature-bound nucleotides are then imaged, isolated, extracted, amplified and sequenced by single-molecule detection methods disclosed herein. Single-molecule imaging is achiev ed by AFM (Radmacher et al. ( 1992) Ultramicroscopy 42-44:968). A bivalent heteropolymenc template compnsing the first and second defined sequence is synthesized on an automated DNA synthesizer, optionally including rhodamine-modified nucleotides to enable ev aluation of template binding to first and second surface featores. The adhesive properties of the template are evaluated by titration of templates onto the first or second surface followed by an aspiration and or washing to remove excess. Following validation, the heteropolymenc template is advantageously converted into a nonnucleotide medium by two cycles oi molecular impnnting (e.g., Ramstrom et al. (1993) J. Org. Chem. 58:7562-7564; Shea et al ( 1993) . Am. Chem. Soc. 775:3368-3369) or nucleotide-nonnucleotide transposition as disclosed elsewhere herein. Alternatively , two hybndizable templates are synthesized, each compnsing a tirst defined sequence segment capable of specifically binding one surface teatore. Each template is then specifically attached to its conesponding surface feature, and the surfaces are attached to one another by hybndization oi complementary second defined sequence segments. Whether accomplished by a single heteropolymenc template, an impnnted plastic template or tw o hybndizable synthetic heteropolymers, specific recogmtion of two different structural shapes (i.e., surface features) by a single discrete structure or bivalent template enables attachment of conesponding surfaces in proper register. Templates can also be designed to specifically recognize biological structoral molecules, e.g., keratin compnsmg hair and nails, tor precise and specific binding of safe, lasting, yet reversible cosmetic dyes, pigments and liners. The ability oi shape recogmtion partners to specifically recogmze structural shapes on biological surfaces e.g., teeth, skin, hair, bone, nails, scar tissue, provides unique opportunities for delivery ot targeted pharmaceutical and cosmeceutical devices. Applications tor surface-specific and shape- specific MOLECULAR MACHINES in agncultore, v etennan. environmental, military and industnal settings abound. Specific recogmtion oi surface features as descnbed herein differs irom specific binding as known in the art, and the distinction has important practical implications Unlike specific binding, surface attractiv ity is not competitively inhibited by molecules having the same chemical identity as structoral molecules compnsing a selected surface feature. Nor is crossreactivity observed with congeners and or solution phase molecules that are structoral analogs of molecules compnsing a selected surface feature. As emerging nanofabπcation techniques enable progressively more precise machining of an expanding assortment of different structural shapes at the nanometer-scale, the diversity of specific surface attractivities descnbed herein will evolve into a catalog of usefully distinct and targetable surface features. Highly diverse molecular shape libranes, advantageously paired nucleotide-nonnucleotide libranes of the instant invention, can be used to select recognition elements capable of targeting synthetic and/or nanofabncated surface ieatures compnsing chemically bland surfaces (e.g., silicon, gallium arsenide, synthetic metals, synthetic semiconductors, insulators) and nanostructures compnsing or attaching to chemically bland surfaces (e.g., bucky balls, carbon nanotubes, carbon nanorods and molecular-scale devices, e.g., wires, gates, channels and switches). In other words, as current bulk mateπal processing and microfabπcation technologies ev olve toward the molecular level (i.e., nanometer-scale precision), the ability to design, select, sculpt, shape, impnnt, graft and template specifically recognizable surface features into chemically bland matenals can evolve concurrently. Selection of molecular shape libranes for the ability to specifically recognize emerging surface features enables feature-specific integration of selected molecules and surface matenals. Conversely, surface library selection techniques disclosed herein enable selection of specifically attractive surfaces for attachment of selected molecules, advantageously template-directed molecules compnsing MOLECULAR MACHINES. Bndging the dimensional gap between molecules and substrate matenals are the instant MOLECULAR MACHINES as well as nanostructures hav ing discrete three-dimensional architectures, e.g., bucky balls, carbon nanotubes and carbon nanorods Nucleotide-based and nonnucleotide segments, templates and MOLECULAR MACHINES ot the instant invention enable the functional diversification of chemically bland matenals and diamondoid nanostructures by specific recogmtion of heretofore undescnbed surface features. Multimolecular adherents, i.e., molecular adherents, are molecular bonding or attaching devices compnsing a specific recognition element (i.e., probe) attached to a first selected molecule, wherein the specific recognition element is capable of attaching the first selected molecule to a second selected molecule compnsing a surface. In a prefened mode of operation, the second selected molecule is a structural molecule compnsing an amphibious surface. In a particularly pretened aspect, the second selected molecule is a surface feature compnsing either an amphibious or nonamphibious surface and the specific recognition probe is a shape-specific probe. A molecular adsorbent, i.e., mimetic adsorbent, is a solid phase, matenal, surface or structore compnsing or attaching to a MOLECULAR MACHINE or hav ing a recogmtion property introduced by grafting, templating, copying, impnnting or transposing a segment, template or MOLECULAR MACHINE, or having a recognition property identified by screening and/or selection of a surface library for a specifically attractiv e surface feature. Mimetic adsorbents of the invention, i.e., molecular adsorbents mimicking a heretofore known molecular recognition property, provide the art with matenals and surfaces having solid phase recognition properties heretofore achieved only by immobilization of selected molecules or nucleic acid sequences, e.g., by covalent attachment of a recogmtion molecule (e.g., an enzyme, ligand, receptor or DNA probe) to a solid phase or by specific binding or hybndization of a selected molecule or selected nucleic acid sequence to an immobilized recogmtion molecule. The instant invention provides methods for surface grafting, surface templating, surface feature selection and template-guided surface feature fabncation (i.e., using immobilized selected molecules as recognition shape templates). These methods for fabncating, grafting and templating recognition properties into surfaces are broadly enabling ior development of designer adsorbents useful as immunosorbents, affinity matπces, chromatography supports, and, more generally, separation media for analytical, diagnostic and preparative fractionation, punfication and processing. Molecular adsorbents are also particularh useful for solid phase assembly of the instant MOLECULAR MACHINES, e.g., using specific recognition as a means for site-directed surface attachment of a selected molecule, segment or template compnsing a MOLECULAR MACHINE. In adsorbing a selected target molecule to an acceptor surface, a molecular adsorbent is also capable of removing the selected target molecule from a donor surface (i.e., the target surface). For example, molecular adsorbents compnsing plaque-binding, microbe-binding, dust-binding, pollen-binding, toxin-binding, grease-binding, oil-binding, or even rust- or paint- binding recogmtion properties can be used to remove unwanted substances trom target surfaces, e.g., dental enamel, dental appliances, microelectronic devices, consumer products, machine components and painted, coated, rusted, oiled or contaminated surfaces. The acceptor surface may compnse or attach a cleaning device, matenal or tool, e.g., a brush, sponge, pad, cloth, abrasive or porous surface, and ma} further compnse one or more catalytic recogmtion elements capable of facilitating the degradation, digestion or detoxification of adsorbed target molecules. Multimolecular lubncants, i.e., molecular lubncants are MOLECULAR MACHINES capable of modulating the interaction between two surfaces b} means of a segment-directed or template-directed selected molecule and/or selected nucleic acid sequence, preferabh a structural molecule (e.g., a buckyball, carbon nanotube, carbon nanorod, pohmer, surfactant or glass) or an effector molecule (e.g., a colloid, nanosphere, microsphere or molecular ball beanng), and more preferably a structoral molecule or effector molecule compnsing or attaching to a recognition molecule (e.g., an ohgonucleotide, ligand or receptor) which is capable or binding at least one surface teature or surface-attached selected molecule, segment or template. In a preiened mode oi operation, a multimolecular lubncant compnses a first selected molecule (e.g., a nanosphere) that senes as a ngid or pliable spacer between two surfaces and an attached second selected molecule (e.g., an ohgonucleotide or ligand) that specificalh recogmzes, weakly binds, specificalh binds, hybndizes, tethers, or ratchets the selected molecule to at least one of the two surfaces. In this way, the fnction between the two surfaces can be controlled by coselection of the type and number of recognition molecules per multimolecular lubncant and the type and number of multimolecular lubncants between the surfaces. In a particularly prefened mode of operation, the recogmtion molecules compnse a plurality of oligonucleotides or impnnted segments ratcheted to vanably complementary immobilized oligonucleotides or vanably attractive surface features or surface-immobilized selected molecules, segments or templates, wherein the sequential association and dissociation ot weakly attractive binding pairs results in net mo ement of one surface relative to another, i.e., directional motion. Functional coupling includes electron transfer in and through nucleic acid molecules. Donor-acceptor coupling in DNA has been descnbed (e.g., Risser et al. (1993) J. Am. Chem. Soc 775:2508-2510). Long-range photoinduced electron transfer through DNA has also been reported (e.g., Muφhy et al. (1993) Science 262: 1025-1029), although the conductive properties of DNA have not been definitiv ely established. The electron tunneling reactions studied rely upon photoexcitation of a donor species and quenching by electron transfer to an acceptor. Electron tunneling mediated by the DNA double helix appeared to be relatively long-range, with separation distances up to 40 angstroms. Propagation of electronic coupling through DNA remains controversial, because reported tunneling rates as a function of distance conflict with theoretical expectations. Regardless of the still-unresolved question as to the insulating or conducting properties of DNA, electron transfer between selected molecules specifically bound to DNA has not heretofore been reported. Functional coupling as descnbed herein between pairs or groups of selected molecules specifically bound to defined sequence segments, modified nucleotides or nucleotide analogs compnsing multimolecular devices and tethered molecules includes but does not require electron transfer through nucleotides. Functional coupling as disclosed herein is achieved by specifically binding a selected molecule (e.g., a donor or acceptor species) to a defined sequence segment compnsing a multimolecular device. The specifically bound selected molecule (e.g., a donor or acceptor) may subsequently be covalently attached to the defined sequence segment, but such covalent attachment is optional. The donor and acceptor species are selected from the group consisting of molecular effectors (i.e., effector molecules), advantageously signal-generating species. Some, but not all, signal-generating species are capable of useful electron transfer reactions. Others participate in functional coupling that does not involve electron transfer. For functional coupling of electron transternng effector molecules ot the instant inv ention (e.g., electroactive compounds, redox proteins, redox enzymes, redox mediators, cytochromes), electron tunneling through DNA may be exploited if useful, but such tunneling is not required. Alternatively, the insulating properties of nucleic acids may be exploited, if useful, to maximize the efficiency of functional coupling between donor and acceptor species. The functional coupling descnbed herein relies on specific binding of at least one selected molecule (i.e., a donor or acceptor species) in close spatial proximity to a second selected molecule compnsing or attached to a defined sequence segment. Electronic coupling between electroactive effectors of the instant invention is preferably achieved by intimate proximity between the nucleotide-positioned donor and acceptor species, preferably sustained intimate contact. Sustained intimate contact may be achieved by covalently attaching the nucleotide-positioned donor and acceptor species to one another or, optionally , covalently attaching donor or acceptor species to one or more nucleotides. Functional coupling does not refer to specific binding between two molecules and or nucleic acid sequences, nor does it refer to hybndization between complementary nucleic acid sequences, nor does it refer to the action of a cataly st or enzyme on its substrate or, similarly, the action ot a cofactor, coenzyme, prosthetic group or product of an enzyme molecule on the same enzyme molecule, nor does it refer, more generally, to the interaction between any two members of a pair of molecules heretofore known to specifically bind, hybndize, recognize or spontaneously attract or attach one another, e.g. as a cation interacts with an anion or a chelator interacts with a metal. In other words, a ligand is not functionally coupled to its receptor, nor is a ligand-receptor complex functionally coupled, nor does the binding between a ligand and its receptor entail functional coupling as these terms are defined herein. A first selected molecule or group of molecules or nucleic acid sequence is said to be functionally coupled to a second selected molecule or group of molecules or nucleic acid sequence or to a device (e.g., a sensor, transducer or actuator) when a photon, electron, property, activity, mass or energy of the first selected molecule or group of molecules or nucleic acid sequence is transfened to or trom a second selected molecule or group ot molecules or nucleic acid sequence or to a device. Such functional coupling includes, for example, the participation of selected molecules or nucleic acid sequences as effector molecules, signal-generating molecules, donors or acceptors of mass (e.g., precursors, cofactors or products) or energy (e.g., electrons, photons, or radiationless transfer), reactants, substrates, cofactors, coenzymes, prosthetic groups, catalysts or intermediates in chemical or enzymatic reactions, including, electrochemical, photochemical and mechanochemical processes. Actuator means any device or process capable of prov iding or performing useful work (i.e., a desirable result) in response to a stimulus, e.g., an input from a user, operator, environment, sensor or transducer, particularly useful work resulting from or mediated by the binding or activ ity ot a selected molecule or group of molecules or nucleic acid sequence compnsing a multimolecular device. Actuators of the invention further include devices which compnse, attach, are functionally couple to or are capable of functionally coupling to MOLECULAR MACHINES of the invention, particularly paired MOLECULAR MACHINES and advantageously systems compnsing pairs or networks of paired MOLECULAR MACHINES. Particularly useful nucleotide-based multimolecular de ices of the instant invention that rely on functional coupling as descnbed herein include soluble and immobilized multimolecular switches, multimolecular transducers, multimolecular sensors and multimolecular delivery systems compnsing oligonucleotides, aptamers or synthetic heteropolymers attached to selected molecules, selected nucleic acid sequences or conjugates. Multimolecular devices include, e.g., multimolecular switches, multimolecular sensors, multimolecular transducers, multimolecular drug delivery systems, nucleotide- based molecular delivery systems and tethered specific recogmtion devices compnsing synthetic nucleotide-based, aptamer-based or heteropoh mer- based discrete structures, nonnucleotide scaffolds or multivalent molecular structures. Nucleotide-based means compnsing at least one synthetic defined sequence segment. Aptamer-based and aptamenc mean compnsmg at least one synthetic aptamer. Heteropolymer-based and heteropolymenc mean compnsing at least one synthetic heteropolymer. The positiomng of selected molecules and selected nucleic acid sequences compnsing multimolecular devices disclosed herein relies upon molecular recognition (i.e., specific binding of a selected molecule or hybndization of a selected nucleic acid sequence to a nucleotide or defined sequence segment compnsing the multimolecular device) or structural shape recognition (i.e., specific recognition of a structural shape or surface feature). Once specifically attached (e.g., specifically bound or hybπdized) to a nucleotide or defined sequence segment compnsing a multimolecular dev ice, selected molecules and/or selected nucleic acid sequences may further be covalently attached to one or more nucleotides (including modified nucleotides, nucleotide analogs, nucleotide ligands, nucleotide receptors and associated, conjugated or attached molecules and functional groups) compnsing the nucleotide or defined sequence segment. Selected molecules or selected nucleic acid sequences specifically bound or hybndized to nucleotides compnsing a multimolecular device may optionally be covalently attached to one another or to one or more nucleotides compnsing a defined sequence segment of the multimolecular device (e.g., using crosshnking reagents, enzymes and or inadiation) to stabilize the multimolecular device against dissociation or denatoration of specifically bound molecules or hybndized nucleic acid sequences. Covalent conjugation of nucleotide-ordered selected molecules can also be used to enhance functional coupling between the selected molecules, enabling efficient communication between donor and acceptor molecules, preferably radiationless and radiative energy transfer and including direct electromc coupling. Cov alent attachment to a defined sequence segment compnsing a multimolecular device is preferably directed to a particular functional group, optionally a pair or group of functional groups, compnsing a single nucleotide, modified nucleotide, nucleotide position, nucleotide analog, type of nucleotide or group of nucleotides. Covalent attachment to a selected molecule, selected nucleic acid sequence or conjugate compnsing multiple functional groups and/or multiple types of functional groups (e.g., a macromolecule, polymer or conjugate such as a protein or protein-hgand conjugate) may be advantageously directed to a single functional group, pair or group of functional groups that is umquely represented or preferentially accessible or addressable (e.g., for stenc, electrostatic, conformational or kinetic reasons) in the selected molecule, selected nucleic acid sequence or conjugate. Covalent attachment of nucleotides or selected molecules compnsing a multimolecular device is preferabh achieved by selectively modifying particular or umque functional groups on the nucleotides and or selected molecules to be covalently conjugated, e.g., by site-directed modification as known in the art (e.g., Fisch et al. (1992) Bioconjugate Chemistry 3:147-153; Gaertner et al. (1992) Bioconjugate Chemistry 3:262-268; Offord (1990) In: Protein Design and Development of New Therapeutics and Vaccines (Eds. J.B. Hook and G. Paste), New York: Plenum, pp. 252-282). Alternatively, regiospecific covalent attachment of specifically bound or hybπdized molecules may be achieved by exploiting the favored reaction kinetics between functional groups on closely approaching surfaces of the bound molecules. Reaction conditions can be adjusted to preferentially bond functional groups in nearest mutual proximity , e.g., by selecting a rapid-acting, zero-length or short-spacer, advantageously photoactivatable, heterobifunctional crosshnker and optimizing reaction conditions (e.g., crosshnker selection, incubation time, temperature, pH and buffer conditions, reagent concentrations, photoactivation protocol) to dπve bonding between functional groups on docking surfaces in favor of more distant interactions. The process of specifically binding a selected molecule to a defined sequence segment or nucleotide compnsing a defined sequence segment (e.g., a modified nucleotide, nucleotide analog, nucleotide ligand or nucleotide receptor) followed by site-specific covalent attachment represents a generally useful method for site-directed covalent conjugation, particularly for complex macromolecules (e.g., particularly proteins and polymers) lacking a unique and accessible reactive group. A defined sequence segment, nucleotide hgand or nucleotide receptor selected for the ability to specifically bind a defined epitope of a first selected molecule (even one having no heretofore known specific binding partner, e.g., a novel macromolecular fluorescent donor signal-generating species compnsing multiple chromophores) is first conjugated to a second selected molecule (e.g., a luminescent acceptor signal-generating species) by methods known in the art. High intensity fluorescent microspheres compnsmg multiple energy-transfernng dyes w ith suitable spectral overlap to yield a single emission peak at a selected wavelength are commercially available. as are high molecular weight fluorescent proteins and dextrans (e.g., Molecular Probes, Eugene OR). The conjugated product is a luminescent acceptor-fluorescent signal-generating species conjugate capable ot specifically binding to a defined epitope of the novel donor signal-generating species. The defined sequence segment conjugated to the luminescent acceptor is capable of specifically binding the conjugated luminescent acceptor to the novel macromolecular fluorescent donor to produce a noncovalent donor-acceptor conjugate. Covalent site-specific attachment of the specifically bound fluorescent donor to functional groups on the luminescent acceptor conjugate yields a covalent donor-acceptor conjugate with defined composition (i.e., one defined sequence segment, one donor and one acceptor per covalent conjugate). The same approach may be practiced using nonaptamenc nucleotides. e.g., modified nucleotides, nucleotide ligands or nucleotide receptors, to prepare covalent conjugates of selected molecules, preferabh functionally coupled selected molecules compnsing multimolecular devices. A particular preferred embodiment of site- directed covalent conjugation involves nucleotide-dependent positiomng of at least two selected molecules specifically bound to defined positions of a heteropolymenc, aptamenc or nonaptamenc multimolecular device followed by covalent, site-directed attachment of the selected molecules to one another or to nucleotides compnsing the multimolecular device. Covalent attachment of the selected molecules to one another is particularly useful for preparation of stable, reproducible conjugates with well-defined composition (i.e., speαfic activity), preferably heteroconjugates compnsing at least one macromolecule, more preferabh heteroconjugates compnsing a first selected molecule regiospecifically conjugated to a second selected molecule. Covalent conjugation of nucleotide-positioned effector molecules also provides sustained intimate contact between the effector molecules, enabling maximally efficient functional coupling (e.g., radiative and nonradiative energy transfer), including resonance energy transfer and, advantageously , electromc coupling. Electromc coupling means single-electron transfer and coupling mediated by direct, through-space overlap of the relevant orbitals of the donor(s) and acceptor and by through-bond superexchange(s) and may occur by single-step or multistep processes within a molecule or between molecules positioned by noncovalent ιnteractιon(s) or, preferably , covalent bonding Nucleotide-dependent molecular positiomng, nucleotide-dependent positioning and nucleotide-positioned mean positioning dependent on attachment to a nucleotide compnsing a defined sequence segment or attachment to a defined sequence segment compnsing a nucleotide of a discrete structore and dependent on the position of the nucleotide compnsing the defined sequence segment or the position of the defined sequence segment compnsing the nucleotide of the discrete structore. Nucleotide-dependent functional coupling means functional coupling dependent on or brought about by attachment to a nucleotide compnsing a discrete structore. Nucleotide-directed, nucleotide-ordered, and nucleotide template- ordered mean nucleotide-dependent molecular positiomng, nucleotide-dependent functional coupling and/or the preparation, properties or use of nucleotide-based multimolecular devices Also included are nucleotide and nonnucleotide replicates, clones, mimetics, impnnts and conjugates of nucleotide-ordered multimolecular dev ices, including nucleotide and nonnucleotide replicates, clones, mimetics, impnnts and conjugates thereof. Replication, cloning and mimicking include, without limitation, copies, mimetics, analogs, vanants and progeny prepared, selected and or ev olved with varying degrees of fidelity by rational, combinatonal and/or randomized design, screening and selection methods including but not limited to directed molecular evolution, advantageously including directed supramolecular evolution. Genetic, enzymatic and chemical methods for in vitro and in vivo evolution ot nucleotides and products of nucleotide transcnption and expression are known in the art and will themselves ev olve to suit the puφoses of the instant invention. It will be apparent to the skilled artisan on reading this disclosure that the replicative properties of nucleotides are enabling for development of self-rephcating templates. It is also the self-rephcating properties of nucleotides that renders them umquely useful in high-resolution screening and selection of vastly diverse nucleotide and nucleotide- encoded chemical libranes for aptamers, nucleotide ligands, nucleotide receptors, nucleotide shape probes and pairs of these useful recognition partners, advantageously including catalytic nucleotides and catalytic nonnucleotide recogmtion partners. The inventive step, however in capitalizing on these wonderfully ramifying properties of nucleotides is single- molecule detection and charactenzation, i.e., the ability to detect individual complexes compnsing a selected nucleic acid molecule and its target. The selected nucleic aαd molecule may be an aptamer, a nucleotide ligand, a nucleotide receptor, an aptamenc or nonaptamenc shape recognition partner, or even a nonnucleotide ligand or nucleotide receptor compnsing a nucleotide-encoded chemical library. Single-molecule amplification of the selected probe and/or single-molecule sequencing followed by amphi ication provides a singularly umque tool tor explonng diverse chemical, nucleotide sequence and shape recognition hbranes in a manner untenable with nonamphfiable chemical or polymenc hbranes. The instant invention is therefore drawn in part to the useful method of applying single-molecule detection to the screemng and selection of a mixture ot nucleotide or nonnucleotide molecules, preferabh a highly diverse mixture of molecules that can be characteπzed by single molecule detection. In a most referred mode of operation, the highly diverse mixture compnses molecules or nucleotides that can be replicated, enabling their precise chemical charactenzation. In a preferred embodiment, the library compnses a mixtore of nucleic acids, preferably randomized or vaned on an arbitrary , random or combinatonal fashion with respect 1) length 2) sequence, 3) backbone composition, 4) precursor nucleotide composition 5) chemical or functional groups added at a single nucleotide compnsing 6) chemical or functional groups at a second nucleotide position, 7) distance or number of nucleotides between first and second positions. In a particularly prelened mode of operation, selection is achieved by incorporation into approximately each molecule of the mixtore a preselected donor or acceptor species, enabling selection for a second molecule or sequence compnsing selected molecules w hich is capable oi functioning as an acceptor or donor (i.e., functionally coupling) to the preselected first molecule in a manner dependent on intimate spatial proximity, i.e., intramolecular or lntraassembly coupling. The selected molecule or nucleic acid sequence segment may compnse a probe (e.g., a ligand, receptor, aptamer, shape recogmtion partner) or a catalytic recogmtion partner (e.g.., a nbozyme, catalytic DNA, enzyme or catalyst) and may be a sequence of nucleotides (e.g., an aptamer, nbozyme or catalytic DNA molecule) or a nonnucleotide molecule (e.g., a selected molecule), preferably a heretofore unknown and selectable nucleotide or nonnucleotide molecule. The invention is also drawn to a method for selecting a recognition element (e.g., an aptamer, ligand, receptor or catalytic speαes) from a diverse mixture of preferabh amphfiable molecules (e.g., a nucleic acid library) compnsing a preselected specific recogmtion partner or probe (i.e., an aptamer, nucleotide ligand, nucleotide receptor, shape recogmtion partner) or catalytic recognition partner (e.g., a nbozyme, a catalytic DNA sequence, catalyst or enzyme) attached to a fixed-position nucleotide or sequence, optionalh by specific binding or hybndization. The preselected recognition partner is preferably an effector molecule, more preferably an effector molecule or conjugate compnsing a donor or acceptor signal-generating species. The library is then selected for a second, heretofore undiscovered probe or catalyst compnsing or binding to a selected donor or acceptor molecule or nucleic acid sequence. Selection is directed tow ard a detectable signal resulting from functional coupling brought about by the spatial proximity of preselected and selected recogmtion partners compnsing a single discrete structure. Functional coupling is detected by single-molecule sequencing and amplification as disclosed herein. It will be apparent to the stalled artisan on reading this disclosure that high-resolution selection of a highly diverse library (e.g., greater than 10 12 and preferably greater than about lO 13 molecules) based upon functional coupling between first and second donor and acceptor species cannot be achieved sans single-molecule detection. Discnmination of functional coupling within a single multimolecular structore requires the ability to resolve with single-molecule sensitivity the interaction between donor and acceptor species compnsing the single multimolecular structure. Two or more selected recognition elements can be combined within a single multimolecular structure to provide a useful synthetic template oi the instant invention, i.e., a bivalent or multivalent template capable of assembling nucleotide and nonnucleotide molecules, advantageously positioning the molecules for additive, combined, cooperative or synergistic interaction, i.e., template-directed molecular positiomng and/or functional coupling. Nucleotide templates are combinations of defined sequence segments capable of attaching at least two selected molecules to one another, herein the template is capable oi specifically recogmzing at least one of the selected molecules. The other selected molecule may be specifically, covalently or pseudoineversibly attached to the template. Nucleotide templates can be transcnbed, amplified, replicated and impnnted to provide clones, replicates, mimetics, impnnts, conjugates and progeny therefrom, including nucleotide or nonnucleotide molecular templates. Templates may be synthesized ab initio from nucleotide or nonnucleotide precursors, i.e., molecules, monomers or pohmers, or they may prepared by chemical and or enzymatic methods known in the art, or they may prepared by clomng, replication, transcnption, impnnting, or in vitro amplification, optionally including iterative cycles of willful infidelity and/or directed evolution. Selected recognition elements, templates, multimolecular structures and multimolecular devices may also be immobilized, insolubilized, attached to or operatively associated with an insoluble, partially insoluble, colloidal, particulate, dispersed or suspended substance, and or a dehydrated or solid phase compnsing a solid support. Solid supports include immobilization matnces, insolubilized substances, solid phases, surfaces, substrates, layers, coatings, transducers and transducer surfaces, woven or nonwoven fibers, matnces, crystals, membranes, liposomes, v esicles, gels, sols, colloids, insoluble polymers, plastics, glass, biological, biocompatible, bioerodible and biodegradable polymers and matnces, suspensions, precipitates, microparticles, nanoparticles, microstructures and nanostructures. Commonly used solid phases include monolayers, bilayers, vesicles, liposomes and cell membranes or fixed cells, commercial membranes, resins, beads, matnces, fibers, chromatography supports and other separation media, hydrogels, foams, polymers, plastics, microparticles, nanoparticles, glass, silicon and other semiconductor substrates. Microstructures and nanostructures include, without limitation, microminiatuπzed, nanometer-scale and supramolecular probes, tips, bars, pegs, plugs, rods, sleeves, wires, filaments, tubes, ropes, tentacles, tethers, chains, capillaπes, vessels, walls, edges, comers, seals, pumps, channels, lips, sippers. lattices, trellises, gπds, arrays, cantilevers, gears, rollers, knobs, steps, steppers, rotors, arms, teeth, ratchets, zippers, fasteners, clutches, beanngs, sprockets, pulleys, levers, inclined planes, cords, belts, cams, cranks, w heels, axles, rotating wheels, spnngs, nuts, screws, bolts, shafts, pistons, cylinders, beanngs, motors, generators, gates, locks, keys, solenoids, coils, switches, sensors, transducers, actuators, insulators, capacitors, transistors, resistors, semiconductors, diodes, electrodes, cells, antennae, appendages, cages, hosts, capsules, sieves, coatings, knedels, ultrafine particles and powders and micromachined and nanofabncated substrates, surfaces, layers, films, polymers, membranes and parts including stationary, mobile, attached, tethered, ratcheted and robotic structures, devices, machines, components, elements and features. The attachment may be covalent or noncovalent, specific or nonspeαfic. The method of attachment may be optimized to achieve a prefened oπentation of a synthetic heteropolymer, defined sequence segment, discrete structure, nucleotide-based multimolecular device or specifically bound or hybndized selected molecule or selected nucleic acid sequence. For some applications, it may be desirable that a synthetic heteropolymer, defined sequence segment, multimolecular structore or a selected molecule or selected nucleic acid sequence capable of specifically binding or hybndizing a multimolecular structore be attached to a solid support in an arra , preferably an ordered anay such as a gnd or other pattern, and optionally a three-dimensional anay, e.g., an anay compnsing multiple layers of molecules, nucleotides, multimolecular structures or multimolecular devices. For other applications, it may be desirable that multimolecular structures immobilized to a solid support compnse an anay of nucleotides, optionally arbitrary or randomized sequences or an arbitraπly or randomly arranged anay or library of sequences, e.g., a cDNA array or a library of hybndizable or complementary sequences. Arrays, gπds, supramolecular assemblies, three-dimensional lattices or other patterns of immobilized molecules or defined sequence segments compnsing synthetic heteropolymers, multivalent heteropolymenc hybnd structures and nucleotide-based or nonnucleotide multimolecular structures can be achieved either by surface deposition of defined sequence segments, selected nucleic acid sequences or selected molecules (i.e., ligands, receptors, structural or effector molecules) or by in situ synthesis of selected molecules or polymers on solid supports. Attachment surfaces may be modified by cov alent and noncovalent techniques such as photochemical coupling, plasma treatment, chemical etching, chemical grafting and micromachining processes which are well known in the art such as lithography , thin film deposition, wet and dry substrate etching, plating, bonding, fusion, templating, injection molding, and the like. Defined sequence segments, selected molecules or selected nucleic acid sequences compnsing synthetic heteropolymers, discrete structores and multimolecular structures of the instant invention may be localized at or near a transducer surface by methods including, but not limited to, covalent attachment, hybndization, specific binding, adsoφtion, encapsulation, controlled deposition and or self-assembly. Alternatively, a defined sequence segment, selected nucleic acid sequence, or selected molecule (e.g., a peptide hgand or receptor) can be synthesized on a surface in situ (e.g., Fodor et al. ( 1991) Science, 257:767-772) followed by specific binding or hybndization of a selected molecule. selected nucleic acid sequence or defined sequence segment compnsing a nucleotide-based discrete structure. In addition to surface attachment, synthetic heteropolymers, discrete structures and multimolecular devices may be incorporated or encapsulated within a transducer, e.g., a microv esicle, microparticle, liposome, monolayer, membrane, film, gel or polymer. Multimolecular devices embedded, entrapped or incorporated in this manner can be used to transfer mass, energy, electrons or photons or perform useful work across a membrane or withm a segregated phase, environment or v essel. Methods for embedding, entrapping and attaching substances using hpids, micelles, liposomes, membranes and membrane mimetics are well known in the art (e.g., Betagen et al. (1993) Liposome Drug Delivery Systems, Technomic Publishing Company, Lancaster PA; Gregoπadis, G (Ed.) ( 1993) Liposome Technology, Volumes 1, 2 and 3, Boca Raton, FL, CRC Press). A wide vanety of established techniques may be used to prepare or modify attachment surfaces, including, but not limited to, addition of amino groups by fuming of nitrous acid, bromoacetylation, oxidation by use of plasma, ultraviolet light or an electron beam as energy source in the presence of oxygen and air, chemical grafting, coating with bifunctional reagents (e.g., glutaraldehyde) or polymers (e.g., latex), covalent attachment of linker or spacer molecules, and noncov alent attachment of affinity spacers. Methods for physically and chemically patterning surfaces (e.g., by lithography, etching, plasma deposition, plating, bonding and templating techmques) and for prepanng biomolecular arrays on surfaces (e.g., by in situ synthesis, robotic dotting and spotting, lithographic methods such as photolithography, piezoelectric and Inkjet technologies) are known in the art (e.g., Drmanac et al. (1989) Genomics 4: 114-128; Fodor et al. ( 1991) Science, 257:767-772; Crkvenjakov et al. (1993) Human Genome Program, U.S. Department of Energy, Contractor-Grantee Workshop III, February 7-10, p. 77; Cubicciotti (1993) DNA chips. In: Medical & Healthcare Marketplace Guide, MLR Biomedical Information Services, 9th Edition, pp. 113-115; Pirrung et al. (1993) Human Genome Program, U.S. Department of Energy, Contractor-Grantee Workshop III, February 7-10, p. 173). In a particular prefened embodiment of the instant invention, one or more multimolecular structures or multimolecular devices is immobilized to a solid support compnsing a transducer, i.e., a device and/or process capable of converting the output (e.g., matter, energy and/or heat) of a molecule or group of molecules compnsing a multimolecular complex or multimolecular device to a different form of matter, energy and/or heat, preferably useful work or a detectable signal. Functional coupling between a multimolecular device of the invention (e.g., a multimolecular transducer, a multimolecular switch or a multimolecular sensor) and a transducer surface can occur, e.g., by the transfer of mass, energy, electrons or photons or by coupled chemical or enzymatic reactions that share a common intermediate, mediator or shuttle species. Transducers capable of converting matter, energy, data or information from a first form or state to a second form or state, include, w ithout limitation, electronic, electrical, optical, optoelectronic, electromagnetic, mechanical, electromechamcal, electrochemical, photochemical, thermal and acoustical devices. Transducers include, without limitation, battenes, marking devices, memory devices, mechanical devices, parts, motors and machines, optical fibers and waveguides, evanescent waveguides, light-addressable potentiometπc devices, photovoltaic devices, photoelectπc and photochemical and photoelectrochemical cells, conducting and semiconducting substrates, molecular and nanoscale wires, gates and switches, charge- coupled devices, photodiodes, electncal and optoelectronic switches, imaging and storage and photosensitive media (e.g., films, polymers, tapes, slides, crystals and liquid crystals), photorefractiv e devices, displays, optical disks, digital v ersatile disks, amperometnc and potentiometnc electrodes, ion-selective electrodes, field effect transistors, interdigitated electrodes and other capacitance-based devices, piezoelectnc and micrograv imetnc devices, surface acoustic wave and surface plasmon resonance devices, thermistors, transmitters, receivers, signaling devices and the like. These and other transducers, transduction pπnciples and related devices are known to those of stall in the art (e.g., Taylor (1990) Biosensors: Technology, Applications, and Markets, Decision Resources, Inc., Burlington MA). Transducers of the invention also include devices which compnse, attach, are functionally coupled to or are capable of functionally coupling to MOLECULAR MACHINES of the invention, particularly paired MOLECULAR MACHINES and advantageously systems compnsing pairs or networks of paired MOLECULAR MACHINES. Also included are transmitters, receivers and remote sensing and signaling devices, including paired devices compnsing sensors and/or transducers, advantageously paired MOLECULAR MACHINES. Particularly prefened are remote signaling and sensing systems compnsing networked pairs of paired and functionally coupled MOLECULAR MACHINES. In a prefened aspect of the instant invention, two members compnsing a pair of MOLECULAR MACHINES are functionally coupled to one another by transmission of matter, energy or information whose reception does not require direct physical contact (i.e., attachment) between the member MOLECULAR MACHINES, preferably by transmission of a chemical, electπcal, electromagnetic or acoustical signal. Where a transducer compnses a remote signaling and/or remote sensing system, the signaling substance, energy or information is considered to be a component oi the transducer system. A pheromone, tor example, is considered to be a component of a remote signaling system compnsing a pair of MOLECULAR MACHINES. A first MOLECULAR MACHINE, e.g., compnsing a promolecular delivery system and a second MOLECULAR MACHINE, e.g., compnsing a tethered specific recogmtion device is considered to be iunctionally coupled by a selected molecule (e.g., a pheromone) that is released by the first MOLECULAR MACHINE and sensed by the second MOLECULAR MACHINE. In this case, the chemical messenger is aptly reiened to as a transducer interconnecting a transmitter and a receiver compnsing paired and tunctionally coupled (i.e., donor and acceptor) MOLECULAR MACHINES. In this case, it is the intimate proximity and tight functional coupling of donor and acceptor molecules within each MOLECULAR MACHINE that ironically enables functional coupling between two remote MOLECULAR MACHINES. In other words, intimate proximity and tight functional coupling at the molecular level is necessary and enabling tor functional coupling between paired MOLECULAR MACHINES that are separated in and by space (i.e., not physically unattached to one another). A paired MOLECULAR MACHINE may be a single pair of attached and/or functionally coupled MOLECULAR MACHINES or a pair of pairs, pair of pairs of pairs, or a dendnmenc network of paired pairs of MOLECULAR MACHINES capable of collectively performing a useful function that cannot be performed by one member sans the other Two members oi a paired MOLECULAR MACHINE may be directly attached, indirectly attached or unattached to one another Advantageously, the two members of a pair are functionally coupled, regardless of w hether or how they are attached. Transducers referred to herein typically compnse an organic or inorganic solid support, w hich may be a substrate, particle, matnx, membrane or surface to w hich effector molecules compnsing nucleotide-based or nonnucleotide multimolecular structores can be attached either directly or through conductive, reflective, transmissive or passive ιntermedιate(s) (e.g., a wire, lead, fiber, connector, interface, layer, channel or conduit). Solid supports include, without limitation, inorganic substrates such as silicon, silica, silicates, plastics, polymers, graphite and metals used in microfabncation of integrated circuits; glasses, plastics, polymers and quartz as used in optical fibers, planar waveguides and optical disks; thin and thick films and organic and inorganic monolayers, bilayers, multilayer stacks, membranes, polymers and coatings as used in semiconductors, field effect transistors, photoelectπc devices and sensors; and microparticles. microvesicles, lipid bilayers, dendnmers, nanostructures, and biocompatible polymers as used in diagnostics, drug delivery and medical devices. Multimolecular switches are nucleotide-based or nonnucleotide dev ices compnsing at least two defined sequence segments or specific recogmtion pairs capable oi participating in stimulus-response coupling, l e., functional coupling bet een or among molecules, wherein an input of matter or energy (I e., a stimulus) to a first defined sequence segment, selected molecule or specific recognition pair results in a stimulus-specific, effector-mediated response at or by a second defined sequence segment, selected molecule or specific recognition pair Stimulus-specific responses are definitiv e effector-mediated responses elicited only or approximately only by a specified type or group of molecular or environmental inputs and not, under conditions of use, by unspecified, umntended or lnterfenng substances or energies For example, two defined sequence segments and/or specific recogmtion pairs compnsing a multimolecular switch responsive to a specified stimulus molecule (e.g , a climcal analyte or therapeutic target) may function in an either/or or mutually competitive fashion with respect to their ability to coexist in the bound state. In this case, the binding of the stimulus molecule at a first defined sequence segment, ligand or receptor may result in the release, binding or activation ot a ligand, receptor or effector molecule (e g., a drug or signal-generating molecule) at a second defined sequence segment or specific recogmtion site. Alternatively, binding of a stimulus molecule (e.g., an antigen, particle, virus, microbe, quenching species, dye or conjugate) to a recogmtion site (e.g., an aptamer, ligand or receptor) positioned between donor and acceptor molecules conjugated to defined nucleotide positions of a multimolecular switch can produce as response the activation or inhibition of a particular output (e.g., photon emission by donor or acceptor) by enabling or facilitating (e.g , by semng as an intermediate or cofactor) or interrupting (e.g., blocking, reflecting, or quenching) energy transfer between nucleotide-conjugated donor and acceptor molecules or by stimulating or inhibiting the conjugated donor or conjugated acceptor. In a prefened embodiment, specific binding of a selected molecule, preferably a selected molecule compnsing or conjugated to effector molecule, more preferably a selected molecule compnsing a signal-generating species (e.g , a ligand, receptor or etfector molecule conjugated to a dye, nanoparticle, phosphor, fluorophore or luminescent compound) to an aptamer or modified nucleotide (e.g., a nucleotide compnsing a ligand or a receptor) positioned between two labeled nucleotides (e.g., fluorophore- modified or quencher-modified nucleotides) can stimulate as response the activation or inhibition of photon emission by a multimolecular switch Multimolecular switches of the instant invention may be nonaptamenc, aptamenc or heteropolymenc. A nonaptamenc molecular switch compnses at least two different specific binding or shape recogmtion pairs attached to a defined sequence segment which positions the two speαfic binding or shape recognition pairs for stimulus-response coupling. An aptamer-based multimolecular switch compnses at least two functionally coupled specific recognition pairs, at least one of which is an aptamer sequence. A heteropolymenc multimolecular switch compnses at least two defined sequence segments that participate in stimulus-response coupling, e.g., the influence of binding or activity at one defined sequence segment on binding or acti ity at another defined sequence segment. A multimolecular switch can exist in either ot at least two states: an active state (i.e., a tnggered, stimulated or "on" state) or an inactive state (i.e., a basal, unstimulated, untnggered or "off state). Multimolecular switches configured as tethered recogmtion devices of the instant invention can even exist in two (or more) states that generate different signals, e.g., a first signal in the "off" state and a second, different signal in the "on" state. The state of a multimolecular switch relies upon the relative positions or activities of at least three molecules, at least one of which is a single-stranded, double- stranded or partially double-stranded ohgonucleotide, aptamer or synthetic heteropolymer. A heteropolymenc multimolecular s itch must further compnse or contact at least two additional molecules or selected nucleic acid sequences, at least one of which is a selected molecule. The second molecule may be a selected molecule, a selected nucleic acid sequence or a conjugate thereof. An aptamenc multimolecular switch that does not contain a synthetic heteropolymer further requires, to become operational, at least three additional molecules, including 1) a first selected molecule which is conjugated to or incorporated m the aptamer (e.g., by covalent attachment to the aptamer or by conjugation to or synthesis of a nucleotide or nucleotide deπvativ e w hich is then incorporated as a modified nucleotide dunng aptamer synthesis), 2) a second selected molecule which is capable of specifically recognizing or being recogmzed by the first selected molecule (e.g., as a ligand specifically binds a receptor or an enzyme specifically recognizes a substrate), and 3) a third selected molecule (i.e., the aptamer target), preferabh an effector molecule and more preferably a signal-generating molecule, which the aptamer specifically recogmzes with an affinity dictated by the nucleotide sequence of the aptamer. A nonaptamenc multimolecular sw itch compnses at least a single defined sequence segment that connects two specific binding or shape recogmtion pairs, each having a member conjugated to a nucleotide or compnsing a modified nucleotide of the defined sequence segment. In a preferred embodiment, referred to herein as a tethered specific recogmtion device, tethered recognition device or simply tethered device, nucleotide-based or nonnucleotide multimolecular devices, e.g., multimolecular switches, multimolecular sensors and molecular delivery systems, compnse tethered specific recognition partners, e.g., two members of the same specific binding or shape recogmtion pair covalently or pseudoineversibly attached to different chemical groups, sites or nucleotides of a single molecule, polymer or multimolecular structure, i.e., a molecular scaffold. The molecular scaffold prov ides suitable spacing and/or flexibility between the two tethered members of a specific recogmtion pair to permit the members to speαfically attach to one another under defined conditions, e.g., in the absence of a selected target that inhibits, displaces, reverses, precludes or dissociates specific recogmtion between the tethered members (e.g., a competitor or allostenc inhibitor). Tethered recogmtion devices are stimulus-responsive devices compnsing a molecular scaffold, optionally a nucleotide-based molecular scaffold, and at least two members oi a specific binding or shape-specific pair or four members of two different specific recogmtion pairs, each member being covalently or pseudoirreversibly attached to the molecular scaffold. Each member oi a recogmtion pair compnsing a tethered recogmtion device is covalently or pseudoirreversibly tethered to its specific recogmtion partner, so the partners remain indirectly attached to one another even w hen they are not directly and speαfically attached. Tethered members of a specific binding or shape recogmtion pair, for example, remain connected to one another by covalent or pseudoineversible attachment to a common molecular scaffold (i.e., a molecule or group of molecules), whether the binding partners are specifically bound or unbound (i.e., dissociated). The molecular scaffold preierably compnses a nucleotide, multimolecular structure or individual molecule which is linear, branched, circular, polygonal, bent, folded, looped, jointed, hinged and/or flexible, allowing the permanently attached specific recogmtion partners to exist in either of two states, specifically and directly attached (i.e., attached specifically and directly in a quasireversible manner as well as directly and permanently by covalent or pseudoirreversible means) or indirectly and not specifically attached. At least one member of at least one specific recognition pair compnsing a tethered recogmtion device preferably compnses or attaches to an effector molecule, e.g., a drug or signal-generating species, so that the two states of the device are functionally distinguishable, e.g., by activation or inhibition of the attached effector. The molecular scaffold, preferably compnsing a bifunctional or multifunctional molecule, preierably a heterotunctional molecule, polymer, copolymer or deiined sequence segment which optionally compnses or attaches to a solid support, is designed, selected or engineered to provide suitable spacing and/or flexibility between tethered members of a specific recognition pair to permit interaction between the two members of the pair under defined conditions, e.g., conditional upon the absence oi a stimulus (e.g., a selected target, analyte, competitor or allostenc inhibitor) that inhibits, displaces, reverses or precludes specific binding or dissociates a quasireversible complex between specific recognition partners. One example of a tethered specific recogmtion device is a heteropolymenc multimolecular switch compnsing three defined sequence segments: a first effector- attachment segment, a second effector-inhibiting segment, and a third target-binding segment. An effector species, preferably one capable of existing in both active and inactive or inhibited forms (e.g., an enzyme such as glucose oxidase, horseradish peroxidase, alkaline phosphatase, β-galactosidase, malate dehydrogenase, glucose-6-phosphate dehydrogenase) is attached to the first defined sequence segment, preferably to the 3' or 5 7 end and more preferably to the 5' end, in such manner to retain effector activity. The method ot attachment may be covalent or noncov lent, so long as the association between the etfector species and the first def ined sequence segment is inev ersible or pseudoineversible, l e., sufficiently permanent and stable to remain intact throughout the operational hfespan ot the dev ice Covalent attachment may be achieved, e g , using w ell know n enzymatic and crosshnking methods (ct Wong ( 1991), Chemism of Protein Conjugation and Crosshnking, CRC Press) to attach hapten or protein ef fectors to an amino-, carboxyl- or thiol-modified nucleotide (e g , from Glen Research, Sterling VA and Boehπnger Mannheim Corporation, Indianapolis IN), preferably a modified 3' or 5' terminus and more preferably a 5'-termιnal primary amine Pseudoinev ersible attachment may be achiev ed by specifically binding an avidin-ef tector or strep tavidin-ef lector conjugate to a biotinylated nucleotide or by hy bndizing an ohgonucleotide-effector conjugate to the f irst defined sequence segment The effector-conjugated first defined sequence segment of the heteropolymer is of such length, preferably about tw o to 80 nucleotides and more preierably about 10 to 50 nucleotides, to tether the second (elfector-inhibiting) def ined sequence segment w ithin suitable range and yet with adequate flexibility to effectiv ely inhibit the conjugated effector Nucleotide spacers or sequence(s) are included, as appropnate, to maximize effector inhibition by the second defined sequence segment The third (I e , target- binding) defined sequence segment may be a subset ot the f irst def ined sequence segment, or it may be contiguous with either the first or the second def ined sequence segment This target-binding defined sequence segment is selected to specif ically bind or hybndize a selected target with higher relativ e affinity (as indicated by affinity constant or melting temperature, as the case may be) than that of the second defined sequence segment tor the conjugated effector Hence, in the presence of the selected target molecule or sequence, specif ic binding or hybndization ot the third detined sequence segment to the target disrupts the interaction oi the second detined sequence segment w ith the conjugated etfector On release of effector inhibition by the target (l e , the stimulus), the activ ated effector generates a stimulus-dependent signal (I e , the response) In this particular tethered dev ice configuration, the effector species is tethered to its specific binding partner (I e , the second defined sequence segment) by means of the first detined sequence segment (ι e , the tether sequence) In other words, two members ot a specif ic binding or shape recogmtion pair are mutually tethered, one member being a defined sequence segment (I e , the second detined sequence segment). Both members are attached to a defined sequence segment (l e , the first defined sequence segment) A particularly prefened embodiment ot this heteropolymenc tethered speαfic recognition dev ice is the special case in w hich the third defined sequence segment is not just a subset of the first defined sequence segment, it is one and the same sequence, I e., the device compnses only two detined sequence segments (cf Example 5, vide infra) In this case, the first defined sequence segment fulfills the dual role of 1) tethenng the second defined sequence segment to the etfector species with suitable spacing and flexibility to allow specific binding between the etfector and the second defined sequence segment, and 2) specific recogmtion and binding to a selected target w ith sufficient affinity to disrupt or preclude specific binding between the etfector and the second defined sequence segment. Target binding theretore releases effector inhibition, yielding a stimulus- dependent response (i.e., effector activ ation). The specifically bound effector compnsing a tethered recogmtion dev ice need not be inhibited when specifically bound, e.g.. by a second detined sequence segment. Specific binding between tethered binding partners may also result in activation of the specifically bound effector species, e.g , by proximity -dependent tunctional coupling between donor and acceptor species. In this case, target recognition (l e., by specific binding or hybndization) can inhibit the signal resulting trom a functionally coupled effector and/or increase the signal generated by an uncoupled donor The detectable output may therefore be a decrease in acceptor or coupled ettector signal, an increase in donor signal, or some combination, quotient, product or deriv ativ e thereof In alternativ e modes ot operation, a tethered specif ic recognition dev ice may compnse, e g , a ligand and its receptor conjugated to different sites or positions ot a single detined sequence segment; multiple h bndized, contiguous or connected detined sequence segments compnsing a discrete structure; a sequence of nonnucleotide monomers (e.g., amino acids, sugars, ethylenes, glycols, amidoamines) or a pair or group oi connected polymers compnsing a molecular seal fold; two or more ligands and their conesponding receptors, each conjugated to a different nucleotide position, site or functional group of one or more defined sequence segments or polymers compnsing or attached to a molecular scaffold, and ev en two or more noncomplementary oligonucleotides, each conjugated to a selected molecule, preierably an etfector species, which is tethered by a deiined sequence segment or a sequence of nonnucleotide monomers compnsing a molecular scaffold, each ohgonucleotide preferably being complementary to a diiierent detined sequence segment ot the specific recognition dev ice (e g , Example 4, vide infra) Tethered speαi ic recognition dev ices hav e sev eral distinct adv antages ov er pnor art diagnostic assay s (e.g., lmmunoassay s, DNA probe assays), chemical sensors (e.g , tor blood gases and electrolytes), biosensors (e.g., tor glucose and therapeutic drugs) and drug delivery systems (e.g , biodegradable polymers, gels and transdermal devices) w hich rely on freely diffusible and/or matnx-entrapped recognition reagents, signal-generating species and/or drugs Tethered specific recognition devices are self-contained multimolecular assemblies, i.e., all necessary recognition and effector species compnse or attach a single multimolecular structure or molecular scaffold. Hence the only potentially diffusible species to hinder stimulus-response kinetics, efficiency or reliability is the stimulus molecule (e.g., a selected molecule or selected nucleic acid sequence). Also, tethered recogmtion devices can be designed and constructed with detined molecular composition, owing to scaffold- dependent positiomng of recognition sites. Wi thin-lot and between-lot reproducibihty are theretore limited only by the stability ot constituent molecules and not by the compositional heterogeneity and positional vaπabihty of alternative multimolecular reagent formulations. Additionally , tethered dev ices can be constructed w ith multiple etfector molecules, preferably signal-generating species, in such manner that different dev ice states generate different signals The reportable or actionable output ot the device may therefore be a product, sum, quotient, denvative, function, transformation or algoπthm of two or more signals w hich is more reliable and/or more informativ e than either signal alone For example, a tethered device configured as a binary switch hav ing two distinct states, each generating a different fluorescent signal, produces an output w hich depends on which of two diff erent fluorescence energy transfer acceptors is excited by a donor fluorophore capable ot transferπng energy to one or the other acceptor In a prefened embodiment, tethered specific recogmtion devices descnbed herein are immobilized to a solid support Immobilized tethered dev ices are particularly useful tor dry -reagent product configurations, because etfector species pseudoirrev ersibly attached to a molecular scat told attached to a solid support is not ireeh diffusible in a sunounding medium Hence, on addition of a fluid sample to the dry-reagent dev ice, the concentration of effector species at the liquid-solid interface (I e , within the tethenng distance of the scaffold) remains relatively constant In conv entional specific binding assay systems compnsing a soluble or diffusible reporter or labeled species (e g , tor diagnostic, momtonng and drug discov ery applications, including high-throughput screening) the final concentration of the labeled reagent is inv ersely proportional to the volume ot sample added Any vanabihty in sample v olume influences the concentration of the label and theretore the equihbπum binding result Also, additional reagent additions, separation steps, washing procedures ev aporation and other handling and env ironmental tactors compromise accuracy precision, reproducibihty and sensitiv ity ot the assay Tethered recogmtion dev ices ot the instant invention are relativ ely unaffected by anabihty in sample and reagent v olume additions and fluid manipulations because labeled species (l e ef f ectors) are pseudoinev ersibly attached to the dev ice Ettectors are not f reely diffusible and are theretore not v aπabh diluted w ith v anable v olume addition Immobilized tethered recognition dev ices prov ide the benef its of homogeneous assa} techniques (I e , no need tor physical separation of bound from tree signal-generating species because specific binding influences the activ ity ot the signal-generating species), adv antageoush in a solid phase format that minimizes diffusion distances between participating speed ic binding partners and signal- generating species and also provides intimate contact and theretore rapid, efficient communication w ith a macroscopic dev ice or a surface, preferabh a transducer surface In another preiened embodiment, rev ersible activ ation, repeat-action, tethered specific recogmtion dev ices descnbed herein are used in detect-and-actuate and search-and- destro} modes tor military and defense applications, decontamination, detoxification, environmental remediation, and agnceutical (e g , fertilizers, v accines and pesticides), cosmeceutical, nutraceutical and pharmaceutical applications (I e , smaRTdrugs) and in multimolecular adhesives and molecular adherents In short, tethered specific recognition dev ices oi the instant invention advantageously compnse two members of a specific binding pair or even two different specific recogmtion pairs tethered by covalent attachment or. optionally, pseudoineversible attachment (e.g., using avidin/biotin or a hybndized ohgonucleotide conjugate) to a scaffold compnsing a multimolecular device in such manner that specific binding and unbinding betw een covalenth connected molecules provides a useful and quasirev ersible (i.e., potentially repeatable) function, e.g., stimulus-responsive binary switching. Covalently or pseudoirrev ersibly tethenng specific recogmtion pairs and etfector molecules to the scaffold obv iates dissociative or diffusional loss or dilution of participating binding partners and effectors, providing a reliable, efficient, reproducible and robust multimolecular switch composition. Tethered specific recognition devices are preferabh nucleotide-based (i.e., a nucleotide scaffold is used for molecular positiomng), but can also be constructed using a nonnucleotide scaffold, preferabh a flexible polymer, more preferably a copolymer or heteropoh mer and optionalh a pohmer compnsing tolds. bends, joints, branchpoints and/or hinges. Pnor art relevant to the tethered specific recognition devices descnbed herein includes nucleic acid assays using a nucleotide-based molecular switch compnsing mutually complementan switch sequences capable oi existing either in the hybndized or unh bndized state, depending on whether a selected nucleic aαd target is present (Lizardi, et al., U.S. 5,118,801) Unlike the molecular switches descnbed b} Lizardi et al., tethered speαfic recognition dev ices descnbed herein can respond to an} t}pe of molecular stimulus or surface feature (i.e., nucleotide or nonnucleotide molecules or structural shapes). Also, the instant inv ention does not rely on internal hybndization of sw itch sequences. Although nucleic acid detection can be achieved using tethered recognition devices descnbed herein, e.g., using effector-conjugated oligonucleotides complementan to defined sequence segments of the molecular scaf fold (cf . Example 5), the instant inv ention does not involve the allostenc switch process descnbed b} Lizardi et al. and requires entirely different compositions and methods. First, whereas the allostenc switches descnbed by Lizardi et al. require at least three essential sequence elements (i.e., a probe sequence and two switch sequences), different embodiments of the instant invention can be practiced with as few as two defined sequence segments (e.g., Example 5, vide infra) and even a single defined sequence segment (e.g., Example 7, vide infra). Second, tethered recognition devices of the instant inv ention may be designed to exist in at least two different states (i.e., basal and stimulated or "on" and "off" states), each of which generates a distinctly different signal (e.g., Example 4, vide infra). Multimolecular switches generating a different signal in each state provide a more reliable and informative output than a "signal-when-on" or "signal- when-off" switch, because 1) signaling occurs regardless of the state of the switch, 2) one of two selected signals can sene as a control to ensure the functional integπty of the device, and 3) signal processing, calibration and data reduction algoπthms can be used with a multi- signal dev ice to provide a quantitative result that does not directly depend on the response of a single effector or amplitude of a single signal. Third, unlike the allostenc molecular switch descnbed by Lizardi et al., multimolecular switches of the instant invention can operate by mechanisms other than internal hybndization of complementary nucleotide switch sequences. Fourth, multimolecular switches descnbed herein do not require a nucleic acid probe sequence. Although multimolecular switches of the instant invention can incorporate defined sequence segments compnsing nucleic acid probes for the detection of selected nucleic acid targets, these devices do not necessanly operate by means of an allostenc switch mechanism, i.e., hybndization of target and probe sequences precluding internal hybndization of complementary switch sequences. Fifth, tethered specific recognition devices of the instant inv ention can be distinguished from pnor art molecular sw itches in compnsing combinations of effector molecules and mutually specific ligands and receptors which are both covalently attached to one another, optionally v ia an inte ening molecular scaffold or tether, and capable ot existing in both specifically bound and unbound (i.e., dissociated) configurations. Finally, Lizardi et al. do not descnbe molecular switches capable of detecting selected nonoligonucleotide molecules, i.e.. do not prov ide a general method for detecting different molecules of commercial importance, e.g., clinical, environmental, vetennan, military, agncultural, and industnal process momtonng analytes. Nor do the allostenc switches of Lizardi enable tnggered release of an effector molecule in response to a specific binding event, e.g., drug delivery by a nucleotide-based prodrug. Unlike the hybπdizati on-based switch descnbed by Lizardi et al. the instant invention encompasses numerous embodiments unrelated to diagnostic switches, e.g., a multimolecular switch compnsing a tnggered-release multimolecular drug deliv ery system (e.g., a heteropolymenc prodrug) or a rev ersible tethered specific recogmtion dev ice tor search-and-destroy or detect-and-actuate applications (e.g., detoxii ication, en ironmental remediation, chemical and biological defense, agπceutical deli ery , prodrug targeting and dynamic imaging). Multimolecular devices of the invention which position two or more selected molecules, nucleic acid sequences or conjugates to prov ide additiv e or partially additiv e, combined, simultaneous, cooperativ e or synergistic functional coupling between or among molecules (instead of or in addition to stimulus-response coupling) are ret erred to as multimolecular transducers. Multimolecular transducers are multimolecular devices whose function depends on additiv e or partially additive, combined, simultaneous, cooperative or synergistic functional coupling between or among two or more selected molecules. Multimolecular transducers of the instant invention are capable of transforming a first form or state of matter, energy, order or information into a second form or state of matter, energy, order or information and include, without limitation, molecular channeling dev ices, enzyme channeling devices, molecular processing devices, electron transfer devices, energy transfer devices, and the like. A multimolecular transducer compnses at least two specific recognition pairs or deiined sequence segments that iunction in a combined or concerted manner to perform a function different trom or supeπor to that of any constituent molecule. Aptamer-based multimolecular transducers of the instant invention compnse a single-stranded, double-stranded or partially double-stranded aptamer which is either 1) conjugated to a first selected molecule and specifically bound to a second selected molecule, wherein the second selected molecule is an effector molecule which is iunctionally coupled to the first selected molecule, or 2) a defined sequence segment oi a synthetic heteropolymer. Nonaptamenc multimolecular transducers compnse at least a single deiined sequence segment connecting two specific binding or shape recognition pairs which are functionally coupled to one another, e.g., a member of the tirst specific binding or shape recognition pair, transters mass or energy to a member ot the second speed ic binding or shape recogmtion pair, w herein donor and acceptor members are either effector molecules or conjugates of effector molecules and ligands or receptors. Multimolecular sensors are multimolecular dev ices, optionally compnsing a multimolecular transducer and/or a multimolecular switch, which are capable ot sensing, detecting, measunng, momtonng, determining or quantifying one or more substances or ev ents. Sensor means any and all sensing means and dev ices know n in the art. including, without limitation, mechanical sensors, iorce and mass sensors, velocity sensors, pressure sensors, acoustic sensors, temperature and thermal sensors, chemical sensors, biosensors, electrochemical sensors, optical sensors, electromagnetic sensors, electncal sensors, electronic sensors, optoelectronic sensors, motion sensors, photodetectors, gas sensors, liquid sensors, liquid and solid lev el sensors as well as multimolecular dev ices and tethered specific recognition devices of the instant invention. Sensors of the invention Iurther include dev ices w hich compnse. attach, are iunctionally couple to or are capable ot iunctionally coupling to MOLECULAR MACHINES ot the invention, particularly paired MOLECULAR MACHINES and advantageously systems compnsing pairs or networks ot paired MOLECULAR MACHINES. Multimolecular devices include multimolecular switches, multimolecular transducers, multimolecular sensors, nucleotide-based molecular delivery systems and multimolecular drug delivery systems descnbed herein as compnsing at least two specific recognition pairs or two defined sequence segments. Functional coupling between or among selected molecules and selected nucleic acid sequences is brought about nucleotide-dependent molecular positioning. Tethered specific recognition dev ices compnse at least two members of one specific binding or shape recognition pair or four members of two specific recognition pairs. Each member is either covalently or pseudoineversibly attached to a molecular scaffold. The scaffold may be a defined sequence segment, a nucleotide, or a nonnucleotide molecule. Multimolecular delivery systems and molecular delivery systems are multimolecular structures capable oi binding or stonng and transporting, carrying, providing, presenting, dehvenng or releasing a selected molecule or nucleic acid sequence to a desired target, receptor, site, region, proximity or destination. Like multimolecular switches, transducers and sensors, multimolecular deliver} s} stems compnse at least two specific recogmtion pairs or two defined sequence segments connected and functionalh coupled b} nucleotide-dependent positioning of the constituent speαfic recogmtion sites. Unlike multimolecular switches, transducers and sensors, howev er, a prefened embodiment oi multimolecular deliver}' system construction produces additiv e, combined or synergistic functional coupling of a first and second selected molecule or nucleic acid sequence to a third object (i.e.. a selected target) compnsing a molecule, group oi molecules, process, disease or condition. In other words, a prefened form of tunctional coupling for multimolecular deliv er} s} stems does not involve the exchange of matter or energ} between tvvo specific recognition pairs connected by nucleotides. but instead relies on the combined binding or activ it} of tvvo specific recognition pairs positioned b} nucleotides to modulate the binding or activ it} of a selected target. Mulumolecular drug deliver}' systems aie molecular deli er}' systems capable of facilitating, enhancing, enabling or modulating the administration, deliver} , dosing, safet} , efficac} . release, activation, clearance, pharmacod}namιcs or pharmacokinetics of a drug or prodrug admimstered to or contacting an organism. When used in reference to a multimolecular drug dehvery system, immobilized refers either to an insoluble multimolecular structore or to a multimolecular structure that is rendered insoluble by attachment to a biological or biocompatible solid support. Biocompatible means an exogenous substance that is relatively nonimmunogemc, nonallergemc and nontoxic when administered in vivo. A drug is any molecule, group of molecules, complex or substance administered to an organism for a diagnostic, therapeutic, forensic or medicinal puφose, including medical imaging, diagnostic, therapeutic, prognostic or prev entiv e screening, detection or momtonng. contraceptive, cosmetic, nutraceutical, pharmaceutical, prosthetic and prophylactic applications. Prodrugs are drugs, drug precursors or modified drugs w hich are not fully active or available until converted in vivo or in situ to their therapeutically active or available torm. Prodrugs of the instant inv ention include drugs specifically bound in inactive form to a first ligand, receptor or defined sequence segment of a multimolecular drug deliv ery system, wherein the inactiv e drug is released or activated by binding of a ligand or receptor, preferably a therapeutic ligand or receptor, at a second defined sequence segment, ligand or receptor compnsing the multimolecular drug delivery system. Nonaptamenc nucleotide-based multimolecular devices compnse at least tvvo specific binding or shape recognition pairs attached in a site-directed manner to a defined sequence segment or plurality of attached defined sequence segments. At least one specific binding or shape recognition pair advantageously compnses an effector molecule. The defined sequence segment prov ides for ordered attachment of the tvvo specific binding or shape recogmtion pairs in suitable spatial proximity that binding or activity of a member of a first specific binding or shape recognition pair influences the binding or activ ity of a member of the second specific binding or shape recogmtion pair. A nucleotide-based nonaptamenc multimolecular sw itch typically compnses two and optionally more than tvvo specific binding or shape recogmtion pairs attached to nucleotides of a discrete structure and thereby attached to one another by nucleotides. The specific binding or shape recogmtion pairs are typically positioned w ithin about one micron of one another, preferably within about 100 nm of one another and more preferably within about 10 nm of one another, by site-directed attachment to nucleotides compnsing or hybπdized to a defined sequence segment. In the simplest case, a first member of a first specific binding pair (e.g., biotin) is attached to (or incorporated as) a 3'-modιfιed nucleotide of a defined sequence segment (e.g., using biotin phosphoramidite or a biotin- spacer-support). A first member of a second specific binding pair is attached to (or incorporated as a constituent of) a second nucleotide of the deiined sequence segment (e.g., by incorporation of a fluorescein-labeled 5'-termιnal nucleotide). The number ot nucleotides between nucleotide-attached members of the first and second specific binding pairs is designed to preclude simultaneous binding oi both specific binding pairs, i.e., the defined sequence segment provides inadequate docking space for second members of both specific binding pairs to remain bound within a single discrete structore. Hence, the mutoal proximity of the two specific binding (and optionally shape recogmtion) pairs brought about by site-directed attachment to the defined sequence segment sets up a mutoal competition between the two specific binding pairs In the presence of both members of both specific binding pairs (at equimolar concentrations), only the higher affinity specific binding pair remains specifically bound. The lower affinity specific binding pair preferentially dissociates, and rebinding is stencally hindered by specific binding ot the higher affinity pair. In a prefened embodiment of a nucleotide-based multimolecular switch, the lower affinity specific binding pair compnses donor and acceptor members which are specifically bound and functionalh coupled, e.g., by fluorescence energy transfer. The second, higher affinity specific binding pair compnses a nucleotide-conjugated receptor directed against an analyte (e.g., a diagnostic marker, a pesticide, an environmental pollutant, an infectious contaminant), wherein specific binding does not occur unless and until the multimolecular switch comes in contact with the analyte. In the presence of the analyte, high-affinity binding between analyte and receptor induces dissociation of the lower atfimty specific binding pair, interrupting fluorescence energy transfer. Activation of the switch by analyte is thus detectable by an increase in emission of the donor fluorophore, a decrease in emission of the acceptor fluorophore, or a change in the ratio of the tvv o. Aptamenc and heteropolymenc synthetic defined sequence segments ot the instant invention can be selected for their ability to specifically bind nonoligonucleotide molecules using pnor art aptamer selection methods (e.g., Gold et al., U.S. 5,270,163), Ellington and Szostak (1990) Nature 346:818-822), Bock et al. ( 1992) Nature 255:564-566, Wang et al (1993) Biochemistry 32: 1899-1904, and Biehnska et al. (1990) Science 250:997-1000) that rely on repeated cycles of contacting an ohgonucleotide mixture ith a target nonoligonucleotide molecule, affinity -dependent partitioning ot the ohgonucleotide-target complexes from unbound oligonucleotides, and amplifying the target-bound oligonucleotides. Alternatively , aptamenc defined sequences of the instant invention, particularly aptamenc defined sequence segments compnsing synthetic heteropolymers or multimolecular devices, can be selected by methods that do not rely on the combination of affinity -dependent parti tiomng and amplification. For example, a synthetic aptamer may be selected from a mixture of nucleic acids, preferably a diverse mixture or nucleic acid library and more preferably a div erse mixture or library of nucleic acid molecules compnsing at least one randomized sequence, based upon the ability to assemble tvvo molecules or groups of molecules, preferably selected molecules and/or conjugated and/or immobilized selected molecules, more preierably selected molecules compnsing ei lector molecules and most preierably selected molecules compnsing signal-generating molecules, so as to render the assembled molecules or groups of molecules distinctly detectable, preferably as a single discrete structure. In a prefened embodiment, selected molecules, preierably signal-generating molecules, are assembled in suitable proximity to produce a detectable image or signal whose detection enables the identification and isolation of a single discrete structure compnsing an aptamer, preferably a single aptamer or a pair of aptamers, which attaches the selected molecules. In a related embodiment, selected molecules, preierably donor and acceptor signal-generating molecules, are assembled in suitable proximity to produce a detectable image or signal whose detection enables the identification and isolation of a single discrete structure compnsing at least one aptamer, preferably a single aptamer or a pair of aptamers, which attaches the selected molecules within suitable spatial proximity tor functional coupling between the donor and acceptor signal-generating species. The resultant assembly compnses donor and acceptor signal -generating species attached and functionally coupled by at least one aptamer, preferably a single aptamer or pair ot aptamers. The method for isolating and identifying (e.g., sequencing) the aptamenc sequence capable of connecting and functionally coupling two selected molecules may involve amplifying the sequence using, e.g., PCR, LCR, Q-beta rephcase, 3SR, TAS, RCR, CPR, nbonuclease H or reAMP methods, but amplification is not required. For example, a combination of optical microscopy (e.g., using bnght-field, epi-fluorescence or confocal methods) and scanning probe microscopy (SPM; e.g., atomic lorce microscopy (AFM), scanning force microscopy (SFM) or scanning tunneling microscopy (STM)), including hybnd techniques such as scanning electrochemical microscopy (SECM), can be used to image, isolate and extract an aptamer-coupled effector complex from a mixture. Further, the aptamer may be isolated trom the complex, e.g., by application oi a current, voltage or piezoelectnc force. A prefened method relies on the integration of fluorescence detection with AFM (e.g , Radmacher et al. ( 1992) Ultramicroscopλ 42-44:968), enabling rapid fluorescence imaging oi large fields followed by high-resolution AFM probing and extraction of selected aptamers. Alternatively, high-throughput screening and selection at high resolution can be achieved by multiplexing AFM probes, one or more probes optionally compnsing separate detection, extraction and/or amplification tips, preferably a microrobotic array ot multiplexed probes attached to cantilevers, each probe, set or bundle compnsing application-specific tips (e.g., for topographical scanning, aptamer-target extraction, aptamer-target dissociation, amplification, and/or sequencing) In a prefened mode ot aptamer selection by proximity -dependent functional coupling, selection relies on the concerted activities oi two or more amplification enzymes, e g , a polymerase and a reverse transcnptase, assembled by aptamer-target binding A tirst amplification enzyme is preierably conjugated to a target molecule, adv antageously through a flexible spacer molecule, scaifold or tether that provides the enzyme w ith at least a moderate degree oi diifusional and rotational treedom. A second amplification enzyme is conjugated and/or tethered to a fixed nucleotide of a nucleic acid molecule compnsing a random-sequence mixture. In this way , aptamer-target binding results in assembly oi amplification enzymes into a single discrete structure compnsing a preierentially amplified nucleic acid molecule. Aptamer detection by target-dependent iunctional coupling oi amplification enzymes adv antageoush represents a homogeneous assay method, as aptamer- target binding alters the activity of a signal-generating process, i.e., replication oi the target- bound nucleic acid to yield a detectable number of copies. Smgle-molecule sequencing oi the selected aptamenc sequence can be achieved, e.g., by discnminating the diifenng fluorescent signals ot indiv ldual nucleotides in response to laser excitation, preierably laser-induced multicolor fluorescence ot fluorophore-tagged nucleotides Alternatively, rapid sequencing oi DNA may be achiev ed w ith AFM (e.g , Hansma et al. ( 1991b) J. Vac. Sci. Techn. B 9' 1282- 1284). ob iating the need to extract aptamers irom the AFM substrate tor amplification and/or sequencing Single-molecule aptamer selection and charactenzation can also be achieved without single-molecule sequencing. A vanety ot signal-generating species can be detected with single-molecule sensitivity (e.g., enzymes, dyed microspheres, fluorescent liposomes. tanned red cells) Single-molecule isolation methods such as optical trapping (e.g., optical iorce, laser scanning or optical tweezer methods) or SPM-based extraction (e.g., AFM, STM) can be used to deliver a single nucleic acid molecule to an amplification vessel, thereby enabling replicative production ot a sufficient number oi copies of a single, isolated nucleic acid molecule for routine sequencing (e.g., using a sequencing gel or automated DNA sequencer). Smgle-molecule detection methods of the instant invention include optical force fields (e.g.. optical tweezers, laser scanning), scanning probe microscopy (e.g., SPM, AFM, SFM. STM and hybnd techniques, e.g., SECM) and emerging but heretofore unprov ed techmques. Methods and dev ices capable ot single-molecule detection which have not heretoiore demonstrated adequate sensitivity are included w ithin the scope of the instant invention. Emerging methods and devices for single-molecule detection include, without limitation, mass spectrometry; capillary electrophoresis and microminiatunzed electrophoretic detectors, including on-chip electrophoretic elements, channels and anays; microminatunzed and nanofabncated optical, spectroscopic, spectrometnc, electrochemical, optoelectronic and electronic detectors; microsensors, nanosensors, integrated on-chip sensors, transducers and anays; and molecular sensors and transducers, including multimolecular sensors, multimolecular transducers and tethered specific recogmtion dev ices ot the instant inv ention. Prefened single-molecule detection and manipulation methods of the instant in ention include optical trapping (e.g., optical tweezers, force fields, laser scanning and manipulation) and scanning probe microscopy (e.g., SPM. AFM, SFM, STM and hybnd techniques, e.g., SECM). SPM, f or example, can be used to detect and isolate a single, target-bound aptamer from a mixture or library of nucleic acid molecules. The isolated aptamer can then be either 1) sequenced in situ by SPM. optionally w ith localized amplification 2) transfened to a single-molecule sequencing apparatus (e.g., a laser-dnven nucleotide fluorescence detector) followed by large-scale synthesis of the selected sequence, 3) transtened to an amplification reaction followed by , e.g., gel-based or automated sequencing, or 4) optionally amplified in situ either on the target-modified SPM substrate or on the target-modified probe tip, e.g., by in situ hybndization (e.g., Patterson et al. ( 1993) Science 260:976-979) and optionally by pnmer extension. Amplification may be achieved v ia thermal cycling (e.g., using PCR or LCR) or, advantageously , by isothermal methods (e.g., 3SR or CPR). Methods disclosed herein for selecting synthetic defined sequence segments capable ot speciiically binding selected nonoligonucleotide molecules using single-molecule detection of an indiv idual aptamer-target complex and/or single-molecule isolation of an indiv idual aptamer-target complex and/or single-molecule amplification oi an aptamer comprising an indiv ldual aptamer-target complex and or single-molecule sequencing of an aptamer compnsing an individual aptamer-target prov ide the art w ith the ability to select and unambiguously charactenze a single aptamer molecule, i.e.. to determine the chemical identity oi an indiv idual target-binding nucleic acid molecule without artiiacts or contamination from nontarget-binding or target-nonbinding nucleic acids (e.g., matπx- binding nucleic acids and/or contaminating nucleic acids retained due to uncontrolled selection pressure or ineffectiv e or inefficient preselection or counterselection methods, or imperfect specificity , selectivity, effectiveness or efficiency of the partitioning method or composition). \ combination of single-molecule detection, isolation, amplification and/or sequencing as disclosed herein enables the selection, charactenzation and identification of an individual nucleic acid molecule capable of specifically binding a selected nonoligonucleotide molecule from a mixture of synthetic nucleic aαds, optionally a highly div erse mixture and preferably a highly diverse library compnsing synthetic nucleic acids. Unlike pnor art methods, the single-molecule selection methods descnbed herein enable the unambiguous identification of an individual aptamer molecule without iterative cycles of partitioning and amplification heretofore required to eliminate, remove, separate, reject or discard contaminating nontarget-binding and target-nonbinding nucleic acids. In other words, unlike pnor art aptamer selection methods, the instant single-molecule selection methods do not rely on affinity -based partitioning ot one population, pool or fraction of nucleic acid molecules (i.e., target-binding nucleic acids) from another population, pool or fraction of nucleic acid molecules (i.e., nontarget-binding or target-nonbinding nucleic acids). In fact, the instant single-molecule selection methods do not rely on any form of partitioning, separating or discnminating tvvo or more populations, pools or fractions of nucleic acids based on any selection cπtenon (e.g., affinity , activity, structure or function). Rather, the instant single-molecule synthetic aptamer selection methods rely on the detection and isolation, and preferably the sequencing and or amplification, ot an indiv idual synthetic aptamer molecule or a synthetic aptamer molecule compnsing an individual discrete structure, w hich methods are heretofore unknown in the art. Proximity-based methods for single-molecule detection disclosed herein include proximal probe methods (e.g., AFM, STM) with reporter molecules (e.g., macromolecules, polymers or preferably nanoparticles or microparticles) to select and isolate one or more aptamers based upon a user-detined selection cnteπon or setpoint (e.g., target- binding affinity). For example, by varying the size, density, surface charge and/or solubility of a reporters conjugated to the target molecule, on the one hand, and random-sequence nucleic acids, on the other, an individual aptamer or group of aptamers can be selected ith desired binding strength. The affinity or binding strength required for aptamer-dependent assembly and maintenance of paired reporter particle complexes increases with the cube of the diameter of each associated particle. Increasing reporter particle size can therefore be used to establish an affinity threshold favonng selection of individual aptamers capable of passing an operator-defined fitness test (cf. Example 16, vide infra). Alternatively, single-molecule affinity selection can be achieved by immobilizing a target molecule to an SPM tip (i.e., negatively charged silicon mtnde) used to probe a random-sequence, nanosphere-conjugated nucleic acid library. Scanning is performed in fluid mode to detect aptamer binding to the tip-immobilized target following application of the nucleic acid library sample to a freshly cleaved mica substrate. The force of aptamer binding to the target-immobilized probe tip is quantified by v arying loading and discharge forces associated with aptamer-nanoparticle binding and unbinding to target-probe tip. Individual, high-affinity aptamers are selected on quantitative grounds against an operator- defined binding force specification. In another prefened aspect of the instant inv ention. the cntical selection cπtenon lor identity ing an aptamer capable oi speciiicalh binding an identified nonoligonucleotide molecule is not affinity (i.e., partitioning as descnbed b} Gold et al., U.S. 5,270,163), but the specific site of interaction on the identified molecule and/or the specific epitope or region recogmzed and/or the degree of surface interaction between the aptamer and the identified molecule and/or the degree ot selectivity tor the identified molecule, I e., the specificity of interaction. For example, an aptamer ma} be selected from a mixture of nucleic acids, preierably a div erse mixture or hbran ot nucleic acid molecules compnsing at least one randomized sequence, based upon the ability ot the aptamer to displace (i.e.. dissociate) a ligand-receptor complex by binding to either the ligand or the receptor at or near the epitope recognized b} its specific binding partner (i.e., the receptor or ligand, as the case ma} be) In this embodiment, both the ligand and the receptor oi the ligand-receptor complex are preferabh labeled w ith effector species (or, optionalh . either the ligand or the receptor is labeled w ith an eilector) in such manner that a single hgand-ei lector conjugate and/or a single receptor-effector conjugate can be distinguished irom a single (hgand-receptor)- effector complex, optionally from a plurality of (hgand-receptor)-ef fector complexes. In another prefened aspect of the instant inv ention. defined sequence segments are selected tor the ability to bind neither a ligand nor a receptor, but to recognize an epitope, site or topographical region formed b} a selected molecule (i.e., a pair or group of molecules) compnsing a ligand specifically bound to its receptor. In this case, the selection process does not involv e affinit -based partitioning of hgand-bound or receptor- bound nucleic acids from the unbound fraction ot a diverse mixture of nucleic acids. Rather, nucleic acids capable of binding ligand alone or receptor alone are discarded (i.e., selected out tor undesirable specificit ) Unbound nucleic acids are screened or selected for the ability to specifically bind the ligand-receptor complex and lo unbind (i.e.. dissociate) concomitantly with disruption of the ligand-receptor complex (e.g., by addition of a competing ligand or receptor or by addition of salts, acids, bases, detergents, or mild chaotropes). Some of the highest affinity nucleic acids (I e., those binding the ligand- receptor complex w ith the highest affinity ) may be deselected (i.e., discarded) by this procedure, because the selection cntenon is not af finity , but specificity . In this way, aptamers are selected for the ability to specifically recognize an ev ent or interaction, i.e., the specific binding between a hgand and its receptor. Aptamers capable ot specifically binding a pair or group of molecules in this manner, i.e., with specificity tor an epitope or site or topological region umque to the specifically bound pair or group, are particularly useful as defined sequence segments compnsing multimolecular drug deliv ery systems (e.g., tor targeting drugs based upon a pathophysiological interactions between ligands and receptors) and in multimolecular transducers and multimolecular sw itches, particularly multimolecular sensors (e.g., for sensing specific interactions between ligands and receptors, particularly a specific binding reaction between a probe and an analyte). In another prefened embodiment, selection of a defined sequence segment capable of specifically binding an identified nonoligonucleotide is based not upon the partitioning of target-bound from free nucleic acid molecules, but on the ability to protect a selected nonoligonucleotide molecule irom structoral modification, e.g., thermal denaturation enzymatic digestion or chemical modification. For example, an aptamer may be selected from a mixture ot nucleic acids, preferably a diverse mixture or hbrary of nucleic acid molecules, based upon the ability of the aptamer to bind and protect a selected target molecule irom cov alent modification, e.g., by shielding a peptide hormone trom cleavage by an endopeptidase or insulating all or part of a glycoprotein antigen irom proteolytic degradation by a protease or protecting an Fab or MRU or hinge region oi an antibody trom enzymatic digestion or chemical modification In another preiened embodiment prov iding adv antages ov er single-molecule atfimty selection, a selected target (e.g., alkaline phosphatase: AP) is immobilized to the silicon nitnde AFM probe tip and used to probe a random -sequence, nanosphere-conjugated RNA hbrary applied in solution (i.e., ireely diffusible) to a treshly cleav ed mica substrate On detection ot aptamer binding to the probe tip, v arying unloading (I e , discharge) torces are applied to dissociate aptamer-nanosphere conjugates trom tip-immobilized AP. Individual, high-alfinity aptamers are selected on quantitativ e grounds based on the empiπcal binding and unbinding forces accompanying aptamer-target association and dissociation irom tip-immobilized target, i.e., those displaying a binding force exceeding an operator-established set point (in nanonewtons, relative force, loading and unloading force(s). or force cun es relativ e to a reference ligand-receptor pair such as peroxidase - antiperoxidase. fluorescein-antifluorescein or DNP-antiDNP). In a particularly prefened mode ot operation, a panel of reference ligand-receptor pairs hav ing predetermined apparent af finities (e g . by Scatchard anahsis using labeled hgand(s) and a tamιh(ιes) of unlabeled competitors) are used to establish a (force x apparent affinity ) calibration cune against which the apparent affinity of indiv idual identified aptamer-target pairs can be interpolated from loading and unloading AFM force data. In this wa} , an indiv idual aptamer hav ing the highest measured binding force can be selected against reference apparent affinities determined for nonaptamenc ligand receptor pairs. For example, a tamih of biotin congeners (e.g , biotin, lmidobiotin, dnmidobiotin, iminobiotin) can be selected to represent a broad d}namιc range of affinities for av idin, strepta idin and or recombinant or otherwise modified streptav idin and/or av idin mutants. A panel of biotin deπvativ es or an array of mutant and/ or modified streptaudins permuted against biotin denvatives can be used to calibrate the binding force of an aptamer-target complex over a range spanning many decades of apparent affinity (i.e., as related to inverse concentration on log scale). Alternativ eh , selection cnteπa and stπngencies can be quantitative!} titrated against the empiπcalh determined behavior of a selected population of individually probed aptamer- target complexes. For example, the binding force of a selected population of fluorescence proximit} -imaged aptamenc complexes can be determined either in terms of absolute force (i.e., binding force in new tons) or as apparent affinity against a calibration cune (vide supra). The population distnbution of measured binding forces can then be plotted as a histogram and/or analyzed statistically to enable willful articulation of a use-appropπate set- point for han esting an indiv idual aptamer or a selected plurality or population of aptamers meeting said willful and quantitative set point. The quantitativ e selection process is adv antageoush automated and supported b} a functionally coupled informational s}stem. Quantitative selection ma} alternativ ely be based not upon the magnitude of empincally determined binding force(s) of an indiv ldual aptamer or selected population of aptamers, but upon aptamer specificity for target epitope, an epitope lormed b} a ligand receptor pair or b} contormational changes in a target or ligand receptor pair (optionalh AFM tip-induced). Quantitativ e and discrete (i.e., single complex) discnmination ma} also be based on multimolecular size of the aptamer-target complex (e.g., dimensions in nm). Alternativ ely , selection may be based on the apparent shape of the complex, tip-induced shape changes and/or resistance to shape changes (i.e., πgidit , resilience, compactness), all of which data are useful in selecting aptamenc defined sequence segments of the instant invention, and all of which methods and capabilities are heretofore unknown in the art. Quantitativ e selection may alternatively be based upon aptamer-confeπed stabilization of the target against AFM tip-induced damage, or against stability of the target and/or aptamer to changes in solution or solid phase environment. For example, the stability of the target, the aptamer and/or the aptamer-target complex to organic solv ents, as usef ul, e.g., in microelectronics, industnal, environmental, chemical and polymer processing, adhesive, adherent and adsorbent development, can be used as a selection cπteπon. Or stability to salts, acids, bases, poly amines, detergents, chaotropes, chelators. intercalators. coordinators, crosshnkers, hydrophobic poly mers, photactiv atable reagents, secondary ligands and receptors (i.e., competitors), enzymes indigenous to a particular env ironment, e.g., nucleases, proteases, peroxidases, phosphatases, hpids, proteins and other matnx- activ e agents, crossreactants, interfeπng substances, and so forth. All of these interactions bet een an aptamer, target or aptamer-target complex and its microenv ironment, covalent and noncov alent, specific and nonspecific, ionic and nomonic, reversible and pseudoinev ersible and inev ersible, can be explored and quantitativ ely reported at the single- molecule lev el using methods disclosed herein. Understanding these interactions is important to the selection, design, assembly , stabilization, replication and/or scale-up of well-defined, stable, uniform, precise, reliable, efficiently coupled and robust MOLECULAR MACHINES of the instant invention. None of these interactions can be resolved at the single molecule level by selection methods known in the art (e.g., Gold et al, U.S. 5.270,163), Ellington and Szostak ( 1990) Nature 346:818-822), Bock et al. ( 1992) Nature 255:564-566, Wang et al. ( 1993) Biochemistry 32: 1899- 1904, and Biehnska et al. ( 1990) Science 250:997-1000). Selection of nucleotides for template-directed assembly by methods descnbed herein unleashes a paradigm shift in the utility ot oligonucleotides. Nucleotide-based templating to produce spatially ordered arrangements of molecular effectors expands the scope of nucleotide applications from therapeutics and diagnostics to nonmedical applications (e.g. industnal processes, microelectronics) that do not require physiological conditions. The more conventional use of nucleic acid libranes for drug discovery revolves around the achievable diversity of nucleotides under relativ ely physiologic conditions. The potential shape-charge div ersity of nucleotides can be expanded by screening hbranes under alternative, nonphysiologic solvent conditions, yielding different shape-charge profiles. Since the fitness landscape of a nucleotide library is influenced by hydration state (e.g., bound water, hydrophihc effects), the properties of a nucleic acid library may be dramatically altered when screened and selected in nonaqueous or polar-nonpolar solvent systems. Nucleotides, unlike proteins and peptides, are relativ ely stable to organic solvents. Oligonucleotides directed against selected targets that are both soluble and stable in nonphysiologic, optionally orgamc solvents (e.g. fluorophores, redox mediators, certain enzymes, supermolecules, etc.) can therefore be selected for industnal applications in which nucleotide recogmtion properties promise to be quite useful. Representative uses for nucleotide selection in nonaqueous and organic solvents include, e.g., biochips and biomolecular circuitry; multienzyme catalysis and synthesis in organic media; production of sided (i.e., directional or nghtside out) liposome-nucleotide assemblies for use in industnal environments; and sensors, transducers and actuators for nonaqueous applications (e.g., detection of contaminants in petroleum products, bioremediation, QA/QC of orgamc syntheses). Use of nucleotides denvatized with lipophilic and nonpolar groups also provides a convenient means to onent the instant MOLECULAR MACHINES in monolayers. films. v esicles and coatings that can be reproduciblv layered on transducer surfaces by well know n thin film and thick film deposition methods. In another nucleotide selection method of the instant invention, single-stranded target- binding nucleotides are selected from a diverse mixtore of random-sequence DNA or RNA duplexes or heteroduplexes, preferably duplexes compnsing fixed pnmer annealing sequence(s), by the relative propensity of denatured single-stranded nucleotides to bind a selected target molecule rather that reannealing to form the parent duplex. Alternatively, the selection is performed as a competition between a selected target molecule and a selected nucleic acid sequence (i.e., a complementary or partially complementary strand) for recognition by a single-stranded nucleotide compnsing a random-sequence smgle-stranded nucleic acid library. In either case, the length and degree of complementan ty of duplex regions is used to establish a target-binding affinity set point (i.e., threshold denaturation energy or melting energy) against which aptamenc nucleotides are selected. Smgle-stranded nucleotides or duplexes are preferably labeled (e.g., with fluorophore-tagged nucleotides or fluorescent nanospheres) and are optionally immobilized to a working electrode or a solid phase compnsing, e.g., an electrophoretic gel or chromatograph} support. For selection based on denaturation and target-competitiv e renaturation of duplexes, a denatunng stimulus is applied, e.g., a v oltage (e.g., about -0.5 to about -2.0 v olts) or heat (e.g., to above about 60 °C, preierably abov e about 80 °C) or a chemical denaturant (e.g., high salt, a chaotrope, or a nonpolar solvent). Following thermal, chemical, photochemical or electrochemical denaturation of duplexes, a selected target is added to the resulting single-stranded nucleotide mixture w hich is returned toward its initial, renatuπng state (e.g , by cooling, desalting or depolanzation). A single-stranded nucleotide w hose affinity tor the selected target is adv antageoush greater than the reannealing h} bndization energ} of its corresponding duplex can then be detected, characteπzed, isolated and amplified and/or sequenced b} optical imaging and SPM methods, as descnbed elsew here herein Alternativ eh , iterative c}cles ot partitioning and amplification oi uncharactenzed pools compnsing target-bound single-stranded nucleotides ma} be used to select a relativ eh high- aiiimty aptamer by methods known in the art (e.g., Gold et al.. U.S. 5,270,163), Ellington and Szostak ( 1990) Nature 346:818-822), Bock et al. ( 1992) Nature 255:564-566, Wang et al. ( 1993) Biochemistn- 32: 1899-1904, and Biehnska et al. ( 1990) Science 250:997- 1000). Screening and selection of a nucleotide hbran b} methods ot the instant invention can be also be used to identil} a defined sequence segment capable ot specifically binding not only a single target molecule, but also a complex compnsing tw o molecules specifically bound to one another. In one prei erred embodiment, a nucleic acid library can be counterselected against a selected ligand and receptor and then selected for deiined sequence segments capable ot specifically binding the bound ligand-receptor complex. This method is particularh useful for selecting a donor-labeled or acceptor-labeled defined sequence segment lor use in homogeneous detection ot ligand-receptor binding, w herein either the hgand or the receptor is labeled ith an acceptor or donor species capable oi functional coupling with the aptamer label. For example, an antι-(hgand-receptor complex) aptamer synthesized w ith modified and/or biotinylated nucleotides compnsing or attaching a donor fluorophore (e.g., fluorescem, a c}amne dye, a phycobiliprotem) can be used with an acceptor-labeled receptor (e.g., cyanine dye-labeled or ph} cobi protein-labeled anti-PSA antibod} ) tor detection of an analyte compnsing a ligand (e g., PSA). In this case, the aptamer is specific for an epitope iormed by the PSA/anti-PSA complex. In the presence of PSA, acceptor-labeled antibody is iunctionally coupled to donor-labeled aptamer specific tor the PSA/anti-PSA complex. Using a similar approach, an effector-labeled defined sequence segment (e.g., enzyme-labeled, fluorophore-labeled or luminescent) can be selected for specific binding to a (labeled aptamer)-target complex in such manner that the selected defined sequence segment binds neither the labeled aptamer nor the tree target. Independent counterselection against the free (i.e., uncomplexed) target and the uncomplexed, labeled aptamer, optionally immobilized, allows subsequent selection ot a nucleic acid library for a labeled defined sequence segment capable of specifically recogmzing an epitope compnsing the (labeled aptamer)- target complex, which epitope is iormed by labeled aptamer-target binding. Not only can the labeled deiined sequence segment be selected by functional coupling, but it can also be used in homogeneous specific binding assays relying on iunctional coupling for detection oi aptamer-target binding. Selection oi defined sequence segments capable of specifically binding complexes formed by aptamer-hapten binding provides a means to perform pseudoimmunometπc (i.e., sandwich) assays for low molecular weight analytes. Homogeneous, pseudoimmunometnc assays using donor- labeled and acceptor-labeled nucleotide-based specific binding reagents (i.e., in excess) enables more sensitiv e detection of low molecular weight analytes than possible with a conventional competitive assay architecture. Even greater sensitivity can be achieved in a heterogeneous mode by amplifying a defined sequence segment compnsing specifically bound nucleotide- target complex(es) These detection, selection, isolation, sequencing and or amplification methods provide the art with the ability to identify novel defined sequence segments compnsing multivalent templates for assembly of useful multimolecular de ices Combined ith paired nucleotide library transposition and impnnting capabilities descnbed herein, identit ication oi synthetic nucleotide recognition elements is enabling ior many heretofore unimagined processes and dev ices. For example, sιngle-molecule(s) selection methods disclosed herein enable quantitativ e resolution of aptamer-suriace interactions, e.g., the influence of surface matenals and structural shapes on aptamer-target binding and on the structore and stability of immobilized aptamers, targets and aptamer-target complexes. In addition, and particularly important to microelectronic and industnal, en ironmental and biomedical sensors, transducers, switches and actuators embodied herein, the influence ot hydration state on aptamer, target and aptamer-target interactions and coniormations can be quantitatively assessed at the indiv ldual molecule and complex lev el by the instant methods The ability to charactenze recognition reactions, e.g , binding and catalysis, at the interface between solid and liquid, particularly the structural and functional lntegnty of ligands, receptors and catalysts, particularly enzymes, proteins, nucleic acids, glycoproteins. glycohpids and other macromolecules at the boundary between wet and dry is seminal and enabling toward the development oi fully integrated and iunctionally coupled molecular electronic, optoelectronic, photonic, mechanochemical, multicatalytic and multienzymatic dev ices compnsing ordered assemblies of molecules cooperating with one another and with inorganic or synthetic matenals, preferably electronically active devices iunctionally coupled to the macroscopic world. Similarly important is stable, fast, efficient, reliable collaboration between hard surfaces and soit biological molecules and groups oi molecules compnsing complexes and supramolecular assemblies. Equally important is the adaptation of biomolecular machines to nonaqueous environments, particularly organic solvent systems and harsh chemicals, acids, bases and salts ingrained in the world of micromachimng, photolithographic and semiconductor technologies. Transposing Mother Nature's bounteous secrets in respect of molecular cooperativity to hard and dry surfaces is a challenging and evolutionary process that has yet to be fulfilled. Surface-induced conf ormational perturbations are substantially nontπvial, as amply evident in the art (e.g., Voltan et al. (1991) Int'l. Symp. on Biological Product Freeze-Drying and Formulation, Bethesda, MD. Develop. Biol. Standard 74:73-81; Volkin et al. (1991) Biotechnol. Bioeng. 37:843-853; Hsu et al. (1991) Develop. Biol. Standard 74:255-271; Prestelsta et al. ( 1993) Biophys. J. 65:661-671). Methods disclosed herein for selecting and assembling nucleotide-based and plastic templates compnsing MOLECULAR MACHINES address these technical obstacles through a number of innovations, including: 1) selection of specifically attracti e surface features and reactivities from surface libranes, obviating the need for biomolecule immobilization, 2) mapping recognition properties selected from molecular shape libranes into surfaces, e.g., by template-guided nanofabncation, 3) surface templating, w herein a nucleotide-based or plastic template compnsing a recogmtion element specific for a surface feature attaches by specific recogmtion, 4) use of nucleotide-based and plastic templates compnsing molecular adhesiv es and adherents to bond and bind selected structural and functional molecules and groups of molecules to surfaces, 5) coselection of surface hbranes and molecular shape libranes to identify mutually attractive molecular and structoral shapes, and 6) impnnting selected molecular shapes into selected matenals, e.g., for preparation of designer adsorbents (e.g., for affinity separations, industnal punfication, catalysis and downstream processing). The combination of nucleotide-directed div ersification and templating provides a novel, practical and general approach to integration ot molecular recognition, shape recognition and catalytic properties with industnal matenals. Parent and progeny templates can be used to select and assemble nucleotide-based and nonnucleotide matenals, polymers, adhesives, adherents, adsorbents and lubncants, e.g., as well as complex MOLECULAR MACHINES (e.g., multimolecular devices, tethered specific recogmtion devices, smaRTdrugs). For example, template-guided, attractive lubncants (e.g., surface-feature targeted nanospheres, buckyballs, polymers) can be used to assemble moving parts on surfaces. Specific attachment of MOLECULAR MACHINES can be used to cushion the denatunng and destabilizing impact on biological molecules by dehydration and surface forces (e.g., Prestelsta et al. (1993) Biophys. J. 65:661-671). These are but two of the many ways in which MOLECULAR MACHINES can improve compatibility between molecular shapes, structural shapes and surfaces. Another is to endow chemically bland matenals, structures, substrates and surfaces with specific recognition and catalytic recognition properties heretofore known only to molecules in free space (i.e., unencumbered by bondage to like molecules, e.g., structure and surface neighbors. Another is enhance specific attractivity and catalytic recogmtion properties of surfaces by mapping surface features against free space effector molecule shapes and introducing the properties into surfaces either by grafting (e.g., using surface templates) or by template-guided nanofabncation. Another is to seamlessly integrate specific recognition, catalytic, and, particularly multimolecular and supramolecular functionalities into surfaces heretofore confined to the realm of chemically bland inorgamc matenals. Another is to bndge the dimensional gap between the molecular and macroscopic worlds, between electronics devices and electroactive molecules, between photomc dev ices and photoactiv e molecules, between attractive surfaces and molecular attractors, between drugs and devices, and more generall , between molecules and machines, and more generally , between man and machine and nature. Another is to bndge the solvent gap by using paired hbranes to select templates and selectable molecules in orgamc solvents or solvent systems not conventionally applied to library screening an selection. Another is the ability to charactenze the interaction between an aptamer and its target at molecular scale in functional as well as structural terms Another is the ability to select cooperative molecular pairs using a first selected molecule tethered to a nucleotide compnsing a randomized sequence selectable on the basis ot affinity for a cooperative second selected molecule. Another is to identify competing and interfeπng molecular, particularly biomolecular, interactions. Another is to determine and respect solvent and solute effects at the level of individual aptamenc and intermolecular activities. Another is to individually select, preferably by automated and massively parallel machine-directed scanning, probing, charactenzation and isolation techniques, a single aptamer capable of best performing a particular function, e.g., stabilizing a target or partitioning a drug to a receptor. Another is to identify a pair or group of defined sequence segments, at least one being an aptamer, w herein the sequence segments consort to assemble selected molecules or nucleotides w hich are, in turn, capable ot consorting to perform a useful function that cannot be performed by any constituent aptamer-target pair Another is to identify and respect the significance of wet versus dry at the molecule-transducer interface, as well as molecular and structural factors influencing device integration Additional objectives of the instant nucleotide hbrary screemng and selection methods include: 1) to provide a method of resolving molecular diversity at single- molecule resolution by combining emerging single-molecule and detection technologies with replicatable nucleotide hbranes, 2) to provide a paired nucleotide-nonnucleotide library - based diversity generator for exploπng molecular shape space and structural surface space, 3) to provide a paired nucleotide-nonnucleotide library-based diversity generator functionally coupled to an informational system compnsing paired informational devices compnsmg at least a massively parallel search engine, 4) to provide a smgle-molecule detection method capable of identifying an individual synthetic aptamer, synthetic nucleotide or pair or group of synthetic nucleotides having a selected recognition property, 5) to provide a single- molecule detection method capable of identifying an individual πbozyme, catalytic nucleotide, or pair or group of nucleotides hav ing a selected catalytic activ ity , 6) to provide a multiplexed single-molecule detection method for a) selecting a selected population or library of individual aptamers based on functional or structoral cπteπa or b) charactenzing the activity of a single (i.e., cloned) aptamer species against a diverse array of selected molecules, optionally structurally related, or c) coselecting a selected population of selected aptamers (i.e., an aptamer library) against a selected population of selected molecules (i.e., a molecular shape library) to identify the relationship or fitness profile of interactions between the hbranes, 7) to provide a method for selecting from a library of nucleotide libranes, preferably paired nucleotide-nonnucleotide libraries, a diverse library of aptamers compnsing a defined set, preferably digitally represented and archived, of members selected to recognize (i.e.. map) the recogmtion space ot a selected population of selected molecules, wherein the identities and behavior ot the collective selected population provide information that cannot be obtained from a single selected molecule or pair or subthreshold group, 8) to transpose any selected target molecule or selected population ot selected target molecules into a conesponding antiidiotypic or anti-antiidiotypic or idiotypic nucleotide library, wherein the nucleotide mapping library can be used to further transform the recognition profile of the target molecule(s) into a new and more preferable molecular medium, e.g., a nonnucleotide impnnt medium, i.e., a plastic segment, 9) to provide a method for transforming a defined sequence segment compnsing an aptamer, catahtic nucleotide, hybndizable nucleotide, encoding nucleotide, conjugated or otherwise deπvatized nucleotide, nucleotide ligand, nucleotide receptor or nucleotide catalyst into a nonnucleotide plastic segment by molecular impnnting or, preferably, transposition between paired, functionally coupled, nucleotide and nonnucleotide hbranes. i.e., a nucleotide-nonnucleotide library pair, 10) to provide a method tor translorming a template compnsing at least two defined sequence segments compnsing, e.g., aptamers. catalytic nucleotides, hybndizable nucleotides, encoding nucleotides, conjugated or othenvise denvatized nucleotides, nucleotide ligands, nucleotide receptors or nucleotide catalysts, into a nonnucleotide plastic template by molecular impnnting or transposition between paired nucleotide and nonnucleotide libranes, i.e., a nucleotide-nonnucleotide library pair, 11) to use a nucleotide- based template to assemble selected molecules, thereby creating a useful MOLECULAR MACHINE, 12) to use a plastic template to assemble selected molecules, thereby creating a semiplastic MOLECULAR MACHINE, 13) to use a nucleotide template to assemble plastic impnnts of impnnted selected molecules, thereby creating semiplastic MOLECULAR MACHINES, 14) to use a plastic template to assemble selected plastic molecules, thereby creating a fully plastic MOLECULAR MACHINE, 15) to provide a synthetic process that exploits the replicative and distortional potential of nucleotide amplifiers for the projection and evolution of said MOLECULAR MACHINES in diversity space and retneval (reentry) in nucleotide space, and 16) to thereby create for industnal use self-rephcating MOLECULAR MACHINES selected and evolved for application-specific purposes (e.g., search-and-destroy, tnggered release environmental remediants and agncultural therapeutics), 17) to use said nucleotide-based and plastic MOLECULAR MACHINES as smart matenals, polymers, adhesives, adherents, adsorbents, molecular counting devices, molecular sorting devices, smaRTdrug dehvery devices, 18) to provide a methods for endowing chemically bland matenals, structures, substrates and surfaces with specific recognition and catalytic recognition properties heretofore know n only to molecules m free space, 19) to provide a method for improving the specific attractivity and catalytic recogmtion properties of surfaces by mapping surface features against free space effector molecule shapes and introducing the properties into surfaces either by grafting (e.g., using surface templates) or by template-guided nanofabncation, 20) to provide surface modification methods (e.g., grafting, templating, mapping, surface feature selection) that introduce surface recognition and catalytic functions heretofore confined to the realm of inorganic matenals, 21) to provide a functionally coupled MOLECULAR MACHINE production system compnsing varying combinations of a molecular diversity generator, an informational system, a molecular selection (sorting) station, a template selection (consorting) station, a proximity selection (functional coupling) station, a transposition (casting and molding) station, an assembly (templating) station, a conjugation (painng and stabilization) station and a recycling (salvage) station, wherein each station is functionally coupled to a distortable amplifier (e.g., a modulatable replicator), 22) to provide a method for charactenzing the interaction between a synthetic nucleotide (e.g., aptamer or πbozyme) and its target at molecular scale in functional as well as structoral terms, 23) to provide a method for selecting cooperative molecular pairs using a first selected molecule tethered to a nucleotide compnsing a randomized sequence selectable on the basis of affinity for a cooperative second selected molecule, 24) to provide single-molecule detection methods for identifying factors and interactions that compete or interfere w ith the activ ity ot a nucleotide recognition element (e.g., an aptamer or nbozyme), 25) to provide single-molecule detection methods for determining solvent and solute effects at the level of individual intermolecular activities of synthetic nucleotide recognition elements, 26) to provide single-molecule detection methods enabling individual selection, preferably by automated and massively parallel machine-directed scanning, probing, charactenzation and isolation techniques, of a single aptamer capable of best performing a particular function, e.g., stabilizing a target or partitioning a drug to a receptor, 27) to provide a method for identifying a pair or group of defined sequence segments, at least one being an aptamer, wherein the sequence segments consort to assemble selected molecules or nucleotides which, in turn, are capable of consorting to perform a useful function that cannot be performed by any constituent aptamer-target pair, 28) to provide single-molecule detection methods for identifying and overcoming structurally and functionally stressful interface effects between macromolecules and surfaces, e.g., wet versus dry, hard versus soft, macroscopic versus microscopic, organic versus inorganic and aqueous versus nonaqueous, 29) to provide paired nucleotide- nonnucleotide templates capable of directing the selection, assembly and conjugation of paired and functionally coupled selected molecules compnsing MOLECULAR MACHINES, including transposition into novel molecular media, replication with varying fidelity, to wit, evolution of multimolecular structure and function, 30) to provide methods for bndgmg the dimensional gap between molecular and macroscopic worlds, between electromc devices and electroactive molecules, between photomc devices and photoactive molecules, between attractive surfaces and molecular attractors. between drugs and devices, and more generally, between molecules and machines, and more generally, between man and machine and nature. In another embodiment of synthetic aptamer selection methods disclosed herein, chemical and enzymatic structure probing methods are used to select aptamers with desired target-binding properties and/or to charactenze the interaction between a selected aptamer and its target and or to identify and/or sequence one or more nucleotides compnsing an aptamer, particularly nucleotides compnsing a target-binding region or cognate or consensus sequence of an aptamer. A wide vaπety of structure probing reagents and associated detection methods can be used to charactenze the structure of nucleic acids with atomic resolution (e.g., Shouche et al. (1990) Nucleic Acids Res. 78:267-275; Bach et al. (1990) Nucleic Acids Res. 78:449-458). Structure probing typically relies on enzymes or chemicals selective for and therefore capable of identifying single-stranded or double-stranded regions compnsmg nucleic acids. Selectivities widely used in nbosomal RNA structure mapping, for instance, include SI nuclease, cobra venom nuclease and DMS. SI nuclease is selective for single- stranded regions of substrate RNA, while cobra venom nuclease is specific for double- stranded regions. Although the selectivity of enzymes for double-stranded versus single- stranded regions is useful, stenc hindrance due to the large molecular size of enzymes limits the resolution that can be achieved with these probes. DMS (a methylating agent) is a chemical probe that reacts with guanine and single-stranded ademne and cytosine. Base- paired ademne and cytosine do not react well, because their reacti e residues are involved in base-painng. Commonly used RNA structore probing reagents and associated specificities and detection methods include: RNAse VI, which is specific for double-stranded RNA and can be detected using end-labeled RNA or pnmer extension; RNAse Tl, which is specific for smgle-stranded guamne and can be detected using end-labeled RNA or pnmer extension; RNAse T2, hich is specific for single-stranded RNA and can be detected using end-labeled RNA or pnmer extension; RNAse A, which is specific for single-stranded cytosine and smgle-stranded uracil and can be detected using end-labeled RNA or pnmer extension; DEPC, which is specific for the N7 position of adenine (and to a lesser extent the N7 position of guanine) and can be detected using end-labeled RNA orO by pnmer extension after chemical strand scission; DMS, which is specific for the Nl, N3 and N7 positions, respectively , of ademne, cytosine and guanine and can be detected vaπously using pnmer extension, pnmer extension after chemical strand scission, and or end-labeled RNA after chemical strand scission; CMCT, which is specific for the N3 position of uracil and the Nl position of guanine and can be detected by pnmer extension: and Fe(II)EDTA, which is specific for πbose and can be detected using end-labeled RNA or pnmer extension. Because of their small molecular size and minimal steπc hindrance compared to enzymes, chemical probes provide more detailed information on secondary structure. They do so by modifying bases at Watson-Cnck base painng positions. The three fundamental elements in RNA secondary structure include 1) stems, which are runs of base-paired bases, 2) loops, which are adjacent nonpaired bases, and 3) bulges, which are interruptions of painng within otherwise base-paired stems. If a base is involved in a Watson-Cnck base pair (i.e., in double-stranded RNA), modification by the probe does not occur. If a base is not involved in a Watson-Cnck base pair (i.e., in smgle-stranded RNA), chemical modification occurs. The site of modification can be detected, e.g., by pnmer extension, because modification prevents incoφoration of the next base by reverse transcnptase. Information regarding tertiary structure can be obtained from the availability of N7 atoms (only present in A and G). If N7 atoms are in olved in tertiary interactions, they will not be modified. Detection requires strand scission at the site of modification. The use of structure probing to select and charactenze defined sequence segments compnsing multimolecular devices, particularly aptamenc and heteropolymenc multimolecular devices, enables atomic-scale resolution of the nucleotide recogmtion sites for selected molecules. By identifying within a defined sequence segment the specific nucleotide atoms in intimate contact with a specifically bound selected molecule and by providing precise secondary and tertiary structural information regarding the aptamenc docking region of the defined sequence segment, structure probing can be used to complement synthetic aptamer selection methods disclosed herein (e.g., single-molecule selection, dissociation, stabilization and aptamer-dependent effector assembly methods) and/or pnor art aptamer selection methods (e.g., Gold et al.. U.S. 5,270,163), Ellington and Szostak (1990) Nature 346:818-822), Bock et al. (1992) Nature 255:564-566, Wang et al. (1993) Biochemistry 32: 1899-1904, and Biehnska et al. (1990) Science 250:997-1000) with detailed structoral information. In combination with functional (e.g., binding and activity) information from specific binding assays and functional coupling assays, nucleotide sequence and structore probing information enables determination of quantitativ e structure- activity relationships for nucleotide-based multimolecular dev ices of the instant invention. Quantitative structure-activity relationships enable nucleotide template-ordered multimolecular devices to be developed with maximal control over the relative positions of specific recognition sites. Optimal nucleotide-dependent positiomng of speαfic recogmtion sites means specifically bound selected molecules are properly positioned to perform useful work with maximally efficiency, e.g., by the additive, mutuahstic, synergistic, combined or interdependent activity of molecules functionally coupled withm a nucleotide-based multimolecular device Defined sequences segments of the instant invention are selected to specifically recognize identified nonoligonucleotide molecules, particularly ligands, receptors, structural and effector molecules, particularly for use in aptamenc and heteropolymenc multimolecular devices, e.g., multimolecular drug dehvery systems, multimolecular transducers, multimolecular switches and multimolecular sensors. In a pretened aspect of the invention, selected defined sequence segments provide newly discovered specificities for detecting and characteπzing heretofore unknown receptors and ligands, particularly plant, animal, viral and microbial receptors and ligands discovered through genomic and proteomic research and conesponding newly discovered ligands. Defined sequence segments selected for the ability to specifically recognize newly discovered ligands, e.g., drugs, drug candidates or receptor probes, tor plant, animal, viral and microbial receptors can sene as receptor mimics or mimetics, e.g., soluble sunogate receptors or antiidiotypic ligands usetul in multimolecular drug delivery systems and multimolecular devices disclosed herein. In another preferred aspect of the invention, defined sequence segments are selected for incorporation into multimolecular devices capable of specifically recogmzing and assembling or processing selected molecules, e.g., ligands, receptors, structoral or effector molecules, for which suitably specific or avid ligands or, as the case may be, receptors are either rare or nonexistent. In addition to multimolecular drug delivery systems (e.g., for heretofore undiscovered drugs and/or heretofore undiscovered therapeutic receptors), multimolecular devices compnsing such rare or heretofore nonexistent specificities include multimolecular transducers, multimolecular switches and, particularly multimolecular sensors capable of detecting, quantifying and momtonng selected molecules compnsing hazardous wastes, env ironmental pollutants, chemical and biological weaponry , agncultural diseases, pests and pesticides, foods, food additives and food contaminants, chemical and biological products and contaminants, industnal, chemical and food production and processing streams, microbial, viral and botanical proteomes, antigens, membranes, cells, cell walls and surface markers, and particularly hormones, transmitters, receptors, hpids, proteins and carbohydrates of edible plants and animals. A multimolecular device compnsing an aptamer, modified nucleotide, nucleotide ligand or nucleotide receptor capable of specifically recogmzing a selected target, e.g., a therapeutic receptor, may be used to evaluate and quantify the target-binding properties of the operative recognition element, e.g., by an allostenc mechamsm relying on binding or hybndization of a second recogmtion element to a calibrator compnsing a selected molecule or selected nucleic acid sequence. For example, a labeled synthetic heteropolymer compnsing an anti-target aptamenc first defined sequence segment may be used to quantify the affinity or binding strength of the aptamer sequence for its target (e.g., a drug or therapeutic receptor) by the propensity of the aptamer-target complex to dissociate on hybndization of a second defined sequence segment to a complementary and v anable-length selected nucleic acid sequence (i.e., a melting temperature calibrator). The binding strength of the aptamenc first detined sequence segment for its target can be expressed in terms of the melting temperature or length of hybndized calibrator required to allosteπcally prevent or disrupt aptamer-target binding. Similarly, the binding strength of a receptor-specific nucleotide ligand for its target receptor can be determined using a labeled bivalent nonaptamenc multimolecular device compnsing the nucleotide ligand as a first recognition site and a hybndizable defined sequence segment as a second, allostenc recogmtion site. In each case, hybndization of an allostenc recognition site of a multimolecular device to a selected nucleic acid sequence influences binding of a pπmary target-specific recogmtion site in a quantifiable manner, i.e., aptamer-target or ligand-receptor dissociation can be conelated with the melting temperature of a hybndized allostenc defined sequence segment Alternatively, the allostenc recogmtion site may be a second aptamenc sequence or nucleotide hgand, for example, in which case binding strength of the pnmary recognition site is determined against calibrated, v aπable-affiπity specific binding partners oi the second recognition site (i.e , an affinity or crossreactivity panel). Defined sequence segments of the instant invention capable oi specifically recogmzing nonoligonucleotide molecules may be single-stranded or double-stranded nucleotides compnsing DNA, RNA or even heteroduplexes thereoi. They may be selected by in vitro or in vivo methods, and they may be naturally occurnng or synthetic defined sequence segments Aptamenc multimolecular devices of the instant invention rely on the specific recognition properties of synthetic aptamers, i.e., at least one defined sequence segment compnsing the aptamenc device is an aptamer sequence not heretofore known to occur in nature and function as a biological recogmtion site. Synthetic heteropolymers and heteropolymenc dev ices also compnse at least one synthetic aptamer sequence, but may also include one or more naturally occurnng aptamer sequences (e.g., a biological recognition site or a defined sequence segment selected from a biological library or genomic sequence database . A synthetic heteropolymer compnsing a heteropolymenc multimolecular device may also be hybndized or specifically bound to synthetic or naturally occurnng selected nucleic acid sequences having useful recognition properties and/or functions other than the specific binding and hybndization capabilities of defined sequence segments making up the synthetic heteropolymer, particularly substrate recognition, catalysis, and/or generation of a reaction product or detectable signal. For example, a heteropolymenc device capable of enzyme channeling, enzyme cycling, or enzymatic synthesis, preferably biosynthesis and more preferably chiral synthesis, can be constructed from a synthetic heteropolymer having a first synthetic defined sequence segment specifically bound to a donor or acceptor enzyme, e.g., a dehydrogenase, esterase, lipase, aminotransf erase, glycosidase, phosphatase or protease, and a second defined sequence segment specifically bound or hybπdized to a selected nucleic aαd sequence compnsmg a nbozyme or catalytic DNA sequence. The nbozyme or catalytic DNA sequence preferably compnses at least two elements, a selected nucleic acid sequence capable of hybndizing or specifically binding to the second defined sequence segment of the synthetic heteropolymer and a catalytic element, preferably a synthetic sequence designed or selected for functional coupling to the synthetic heteropolymer-bound enzyme (i.e., designed or selected to donate or accept a substrate or product of the synthetic heteropolymer-bound enzyme or to modulate the binding or activity of the enzyme or to act in an additive, synergistic, cooperative or sequential manner with respect to a common target, intermediate or substrate). Optionally, a molecular effector which is specifically bound to a defined sequence segment of a synthetic heteropolymer and functionally coupled to a hybndized nbozyme or catalytic DNA sequence may also be covalently conjugated to the defined sequence segment. Alternatively, a molecular effector covalently conjugated to a synthetic heteropolymer may be functionally coupled to a nbozyme or catalytic DNA molecule by hybndizing or specifically binding a defined sequence segment of the synthetic heteropolymer to a nucleic acid sequence compnsing the nbozyme or catalytic DNA molecule. In an alternative embodiment, the enzymatic activity of a nbozyme or catalytic DNA sequence may be functionally coupled to a nonenzymatic acceptor hybndized to a synthetic heteropolymer, e.g., by selecting and hybndizing to the synthetic heteropolymer a catalytic DNA molecule or nbozyme capable either of donating a product to a synthetic heteropolymer-bound effector which is a drug or signal-generating species (e.g., a chromogemc or fluorogemc or electroactive or luminescent acceptor). Alternativeh, a nbozyme or catalytic DNA molecule may be selected for the ability' to hybndize and functionally couple to a synthetic heteropolymer-bound effector species b} catalyticalh activating, modifying or releasing the heteropolymer-bound effector species. Bifunctional synthetic heteropohmers of the present invention are prepared in the following manner. Tvvo molecules or groups of molecules capable of performing a useful function when brought into close spatial proximity are identified. At least one of the identified molecules is a nonoligonucleotide molecule, preferably a receptor, ligand, structural molecule or molecular effector. A first defined sequence segment capable of specificalh binding to an identified nonoligonucleotide molecule is selected, preferably b} repeated selection and amplification of ohgonucleotide pools, more preferably by combinatonal selection and amplification of an ohgonucleotide library. A second defined sequence segment capable of specifically binding to the second identified molecule, which may be a nonoligonucleotide molecule or a selected nucleic acid sequence, is also selected. A synthetic heteropolymer compnsing the first and second defined sequence segments, optionally separated by a spacer sequence of vanable length, secondary and tertiary structore (e.g., including stems, loops, bulges, stem-loop structures, pseudoknots and internally hybπdized. branched and hyperbranched sequences) and composition, preferably a smgle- stranded or double-stranded sequence compnsing 1 to 200 nucleotides and more preferably about 1 to 40 nucleotides, is then synthesized ab initio by methods well known in the art. The length and composition of the spacer sequence is such that the spatial relationship between the first and second defined sequence segments is optimal to provide for specific binding of the two identified molecules in close intermolecular proximity. Spacer sequences are single-stranded or double-stranded nucleotides which mαease the topological distance between defined sequence segments (i.e., the number of intenening nucleotides or base pairs) and also influence the spatial distance between them (l e . the a erage or approximate distance in three-dimensional space between two defined sequence segments or between specified nucleotides, regions, positions, structures or functional groups compnsing the two defined sequence segments). Spacer sequences can be used to increase the distance between two defined sequence segments of a synthetic heteropolymer, typically to maintain independent operabihty, i.e , the ability of a defined sequence segment to retain its selected recogmtion properties when incoφorated into a multisegment synthetic heteropolymer Nonlinear spacer sequences, preferably branched, looped, bulged and/or internally hybndized sequences, e.g , dendntic, stem-loop or pseudoknot structures, can also be used to decrease the spatial distance between defined sequence segments or specified regions of a synthetic heteropolymer and therefore to decrease the spatial distance between attached selected molecules or selected nucleic acid sequences. The efficiency of functional coupling between selected molecules within multimolecular complexes can therefore be enhanced by including synthetic heteropolymer spacer sequences that reduce the spatial distance between the functionally coupled molecules. The spacing between defined sequence segments of a synthetic heteropolymer may also be adjusted using one or more spacer modifiers, modified nucleotides or nucleotide analogs compnsing a spacer arm, e.g., SPACER 9, SPACER 18, SPACER C3 OR DSPACER (Glen Research, Sterling VA) Spacing between nucleotides within a defined sequence segment may also be vaned using such spacer modifiers, e g , to maximize the affinity or specificity with which a defined sequence segment specifically binds a selected molecule or nucleic acid sequence Spacer modifiers include, w ithout limitation, nucleotides, spacer arms and groups designed to adjust the distance between nucleotides, defined sequence segments and nonnucleotide molecules, e.g., indiv idual nucleotides, nucleotide analogs, spacer modifiers, spacer sequences, linker oligonucleotides and mutually hybndizable defined sequence segments compnsing multi alent heteropolymenc hybnd structores and nucleotide-based multimolecular devices, and contiguous or punctuated groups or combinations thereof Alternatively, it may be preferable to synthesize a synthetic heteropolymer lacking any spacer modifiers between selected defined sequence segments so that specific binding or hybndization of a first selected molecule or nucleic acid sequence at one defined sequence segment precludes specific binding or hybndization of a second selected molecule or nucleic acid sequence at another defined sequence segment or displaces a previously bound molecule or nucleic acid sequence. It may even be preferable to produce the synthetic heteropolymer with contiguous defined sequence segments shanng a single nucleotide or even a few nucleotides, e.g., with a small number of nucleotides of one defined sequence segment overlapping another defined sequence segment (i.e., common to both), so long as one or the other defined sequence segment is capable at any given time of specifically binding or hybndizing to a selected molecule or nucleic acid sequence. The three-dimensional shape ot the synthetic heteropolymer and ngidity of the spacer sequence may be further modified by hybπdizing or specifically binding one or more nucleotide sequences to the spacer sequence. In the instant application, multimolecular complex refers to a synthetic heteropolymer or multivalent heteropolymenc hybnd structure having at least one identified molecule specifically bound or at least two different aptamer molecules bound to the same target molecule or to a linker molecule. When used in reference to a complex compnsing a synthetic heteropolymer, multimolecular heteropolymenc complex is the preiened term. A complex compnsing at leasi tvvo aptamers may also be retened to as an aptamenc multimolecular complex or synthetic heteropolymer. Two different aptamer molecules joined to one another either directly or via a linker molecule (i.e., a nucleotide spacer, spacer molecule, ohgonucleotide linker or nonnucleotide linker) to compnse a discrete structure capable ot specifically recognizing two different nonoligonucleotide molecules is a synthetic heteropolymer. Similarly, an aptamer molecule and a second defined sequence segment may be refened to as a synthetic heteropolymer, if they compnse a discrete structore capable of specifically recogmzing a nonoligonucleotide molecule and of hybπdizing a selected nucleic acid sequence. Multivalent heteropolymenc hybnd structure refers to two or more synthetic heteropolymers hybndizabh linked. Each heteropolymer compnses nucleotides, preferably oligonucleotides, having at least two defined sequence segments. A first deiined sequence segment of at least one heteropolymer is capable ot specifically binding to a nonoligonucleotide molecule or group ot molecules, preferabh a receptor, ligand, structural molecule or molecular etfector. The first defined sequence segments of other synthetic heteropolymers compnsing the multivalent heteropolymenc hybnd structure are capable either of specifically recognizing a selected molecule or of specifically binding or hybndizing to a selected nucleic aαd sequence or of positioning a conjugated selected molecule within functional coupling distance of a nonoligonucleotide molecule specifically bound to the first defined sequence segment of the first synthetic heteropolymer, thereby enabling functional coupling between the conjugated selected molecule and the specifically bound nonoligonucleotide molecule. Where the first defined sequence segment of the second synthetic heteropolymer is designed or selected to position a conjugated selected molecule for functional coupling to a specifically bound nonoligonucleotide molecule, the nonoligonucleotide molecule is preferably an effector molecule and more preferably a signal- generating species or a drug. The specifically bound nonoligonucleotide molecule is not a ligand or a receptor covalently attached to the conjugated selected molecule. Second defined sequence segments of the synthetic heteropolymers are capable of hybπdizing to each other or to a linker ohgonucleotide, optionally forming a double-stranded recognition site (e.g., an aptamer, immunoreactive epitope or biological recogmtion site) or intercalation site (e.g., for a drug or a dye) between the first defined sequence segment of a first synthetic heteropolymer and the first defined sequence segment of a second synthetic heteropolymer. Linker ohgonucleotide, also reiened to herein as a linker ohgonucleotide, refers to an ohgonucleotide sequence, plurality of ohgonucleotide sequences, monomers or polymers, or a linker molecule capable of specifically binding or hybndizing to two or more conjugated defined sequence segments or to second defined sequence segments of two or more synthetic heteropolymers, thus joining the conjugated defined sequence segments or synthetic heteropolymers into a discrete structore. An ohgonucleotide linker may also join tvvo nucleotides by covalent attachment. Alternatively, an ohgonucleotide linker may attach a first nucleotide covalently and a second nucleotide noncovalently Ohgonucleotide linkers conjugated to selected molecules may also join pairs ot nucleotides by specific binding or b} combinations of specific binding, hybndization and covalent attachment. A nucleotide ma} also first bind a linker o gonucleotide noncovalently and subsequent!} be attached covalenth. Examples of the linker oligonucleotide include, but are not limited to: an ohgonucleotide; a stem-loop, bulged or pseudoknot structure having single-stranded ends capable of hybπdizing to the second defined sequence segments; a duplex, tπplex or quadruplex structure having smgle-stranded ends capable of hybπdizing to the second defined sequence segments; a branched-chain or branched-comb structure having defined sequence segments capable of hybπdizing to the second defined sequence segments; a nucleic acid dendron or dendπmer (e.g., Tomaha et al. (1993) In: Topics in Current Chemistry, pp. 193-245 Spnnger, Berlin) or a dendron, dendnmer or other branched or hyperbranched structure attached to nucleotides compnsing defined sequence segments capable of h}bndιzιng to the second defined sequence segments; a nonoligonucleotide dimer, multimer or polymer compnsing monomenc subunits attached to defined sequence segments of nucleotides capable of hybπdizing to the second defined sequence segments; a heteroconjugate compnsmg a nonoligonucleotide molecule or group of molecules attached to defined sequence segments of nucleotides capable of hybndizing to the second defined sequence segments; a single-stranded or partially single-stranded nucleic acid molecule or group of molecules having a defined topology compnsmg defined sequence segments capable of specifically binding or hybπdizing to the second defined sequence segments; a double-stranded or partially double-stranded nucleic acid molecule or group of molecules having a defined topology compnsing defined sequence segments capable of specifically binding or hybπdizing to the second defined sequence segments; and a cyclic ohgonucleotide or circular structure having defined sequences capable of hybndizing to the second defined sequence segments. Second defined sequence segments, linker oligonucleotides and hybndizable spacer sequences may be selected so as to introduce, v la hybndization of first and second synthetic heteropolymers, duplex regions that can be selectiveh targeted or modified, e.g., by intercalating agents or anti-double-stranded ohgonucleotide antibodies, or that compnse specific recogmtion properties, e.g., a double-stranded aptamer, tπplex- forming sequence or biological recognition site. In addition, duplex regions formed by hybndized defined sequence segments and or linker oligonucleotides can be stabilized, e.g., using crosshnking agents, disulfide bonds, photoactiv atable reagents, irradiation, covalenth linked intercalators, hydrophobic interactions, tnplex-iorming oligonucleotides, or conjugates or combinations thereoi. Linkers, linker molecules, and nonnucleotide linkers, hen used in reference to nonnucleotide molecules that link nucleotides, include molecules capable of joining two nucleotides either covalently or noncovalenth Nonnucleotide linkers include, for instance and without limitation, selected molecules capable of binding two aptamers (i.e., joining tvvo aptamers to form a multimolecular complex), dendrons, nonDNA dendnmers, peptides, proteins, nonnucleotide linkages and bπdges, nonnucleotide monomers, dimers and pohmers, ligands and receptors (e.g., biotin, digoxigenin, avidin, streptavidin, antibodies), hpids, sugars, polyethylene glycols, cholesterol, fusion proteins, bispecific antibodies, chelating agents, intercalating agents, crosshnking agents, and nonnucleotides compnsing bifunctional, heterofunctional multifunctional molecules and nonnucleotide ohgonucleotide linkers Two or more defined sequence segments compnsing a synthetic heteropolymer may be attached to one another by lnternucleotidic linkages, e.g., by automated nucleic acid synthesis, recombinant methods or in vitro replication, transcnption, amplification, hgation or strand extension procedures well known in the art. Alternatively, defined sequence segments compnsmg a synthetic heteropolymer may be attached by covalent methods, preferably using a bifunctional crosshnker and optionally a earner, bndge or spacer molecule or a dendntic or polymenc linker species (e.g., a monomer such as glycine, glucose, monoglyceπde or ethylene diamine, a dendron such as a poly(amιdoalcohol), poly(arylester) or poly(sιloxysιlane) monodendron, a dimer such as glycvlglvcine, or a linear or branched polymer, copolymer or multimer such as an ohgopeptide, protein, polysacchande, fatty acid, fatty alcohol or fatty alcohol methyl ester, a branched or hyperbranched polymer such as a poly(amιdoamιne) dendnmer, or a water insoluble polymer such as polystyrene (i.e., latex), nylon or polypropylene) and more preferably using 3' and 5' terminal linkers with 5' to 5', 3' to 3', or 3' to 5' crosshnkers, particularly heterobifunctional crosshnkers, optionally including a earner, bndge or spacer molecule, monomer, dendron or polymer. Defined sequence segments compnsing a synthetic heteropolymer may also be attached to one another noncovalently, preferabh pseudoineversibh, e.g., using conjugated members of a high-affinity specific binding pair (e.g., avidin/biotin or streptavidin biotin), conjugated chelating or intercalating agents, or conjugated molecules or groups of molecules capable of attaching the defined sequence segments by hydrophobic or lomc association. Methods for prepanng a synthetic heteropolymer by noncovalent attachment of a biotinylated defined sequence segment and a streptavidin-conjugated defined sequence segment are descnbed in Example 6 (vide infra). Tvvo or more synthetic heteropolymers may be attached to one another by hybndization (i.e., to form a multivalent heteropolymenc hybnd structore) or by specific binding (e.g , between defined sequence segments or between a defined sequence segment and a conjugated molecule). Synthetic heteropolymers ma} also be attached to one another either directh or via one or more intenening earner, bndge or spacer molecules or dendntic or polymeπc linkers by covalent or pseudoineversible methods, as descnbed for attachment of defined sequence segments in the preceding paragraph (vide supra). Bifunctional or multifunctional hybπds of synthetic heteropolymers, refened to as multivalent heteropolymenc hybnd structures, may also be formed in accordance with the methods of the invention, having the ability to specificalh bind tvvo or more selected molecules or nucleic acid sequences. A multivalent heteropolymenc hybnd structore compnses at least two synthetic heteropolymers, at least one of which compnses a defined sequence segment capable of specifically binding a nonoligonucleotide molecule. Multivalent heteropolymenc hybnd structores capable of assembling molecules within a multimolecular transducer is prepared as follows. Two molecules or groups of molecules capable of performing a useful function when brought into close spatial proximity are identified, at least one of which is a nonoligonucleotide molecule, preferably a receptor, ligand or molecular effector. A first defined sequence segment capable of specifically binding to an identified nonoligonucleotide molecule is selected, preferably b} repeated selection and amplification of ohgonucleotide pools, more preferably b} combinatonal selection and amplification of an ohgonucleotide library. A first synthetic heteropolymer compnsing the first defined sequence segment and a second defined sequence segment capable of hybndizing to a selected nucleic acid sequence is synthesized by methods well known in the art. A second synthetic heteropolymer compnsing a first defined sequence segment selected to bind the second identified molecule and a second defined sequence segment capable of hybndizing with the second defined sequence segment of the first synthetic heteropolymer is synthesized by methods well known in the art. The first and second svnthetic heteropolymers are then hybπdized through their complementary second defined sequence segments to produce a multivalent heteropolymenc hybnd structure. The hybπdized second defined sequence segments, which may compnse from as few as five to as many as several hundred nucleotides, are of such length, preferably about 5 to 40 nucleotides and more preferably about 8 to 20 nucleotides, to provide for controlled spacing between the two defined sequence segments of the multivalent heteropolymenc hybnd structure that are capable of specifically binding to the identified molecules. According!}, these two defined sequence segments are separated by such distance, preferably 1 to 10 microns and more preferably 2 to 15 nm, to accommodate specific binding of the two identified molecules in close intermolecular proximity. The molecules can then be bound to their respective defined sequence segments of the multivalent heteropolymenc h bnd structure to form a multimolecular heteropolymenc complex with specificalh bound molecules suitably positioned for optimal cooperative function. Multivalent heteropohmenc hybnd structures useful in assembly of multimolecular switches are prepared in a similar manner, but the distance between first defined sequence segments is kept to a mimmum, preferably less than 1 micron and more preferably less than 10 nm, so that binding or activity of a selected molecule or nucleic acid sequence at the first defined sequence segment of a first synthetic heteropolymer influences the binding or activity of a selected molecule or nucleic acid sequence at the first defined sequence segment of a second s}nthetic heteropolymer. The appropnate distance between first defined sequence segments to enable such functional coupling is achieved, for example, by 1) adjusting the length ot the h}bndιzable second defined sequence segments, preferably to less than 20 nucleotides and optionally less than 12 nucleotides (preferably crosshnked in place to produce stable, covalent hybπds), 2) including a nucleotide spacer, spacer sequence or linker ohgonucleotide (e.g., a branched, internally hybndized, dendntic, stem-loop or pseudoknot structure) to create a bend, loop, bulge or branchpoint which increases the topological distance but reduces the spatial distance between first defined sequence segments, and/or 3) including in the synthetic heteropolymers mutually complementary third defined sequence segments whose hybndization within the heteropolymenc hybnd structure forms a bent, looped, bulged, haiφin, knotted or closed-loop structure that reduces the spatial distance between first defined sequence segments to less than that of control structures lacking third defined sequence segments (e.g., a closed-loop heteropolymenc hybnd structure having single- stranded first defined sequence segments bracketed between hybndized second defined sequence segments at one end and hybndized third defined sequence segments at the other end). In accordance with a preferred embodiment of the present invention, two or more nonoligonucleotide molecules or groups of molecules capable of cooperating to carry out a desired function or functions, preferably receptors, ligands, structural molecules or molecular effectors, are assembled in a multimolecular heteropolymenc complex in the following manner. Nonoligonucleotide molecules or groups of molecules capable of cooperating to carry out a desired function or functions are identified. A first defined sequence segment capable of specifically binding an identified molecule is selected for each molecule, preferably by repeated selection and amplification of ohgonucleotide pools, more preferably by combinatonal selection of an ohgonucleotide library. A synthetic heteropolymer or multivalent heteropolymenc hybnd structore compnsing each of the first defined sequence segments is then prepared such that the arrangement and spacing of these defined sequence segments provides for specific binding of the identified molecules in close, spatially ordered intermolecular proximity. The identified molecules can then be speαfically bound to their respective defined sequence segments to form a multimolecular heteropolymenc complex capable of performing the desired cooperative function or functions of the constituent nonoligonucleotide molecules. In addition, a synthetic heteropolymer, multivalent heteropolymenc hybnd structure or multimolecular heteropolymenc complex capable of specifically binding to a selected nucleic acid sequence may be prepared by a modification of the above method, wherein a particular defined sequence segment is selected for its ability to hybndize to a selected nucleic aαd sequence. A synthetic heteropolymer capable of specifically binding to a selected nucleic acid sequence may be prepared by selecting a second defined sequence segment capable of hybndization, preferably a nucleic acid probe sequence A multivalent heteropolymenc hybnd structure capable of specifically binding to a selected nucleic acid sequence may be prepared by selecting a first defined sequence segment of a constituent synthetic heteropol mer capable of hybndization, preferably a nucleic acid probe sequence A multimolecular heteropolymenc complex capable of specifically binding to a selected nucleic acid sequence may be prepared by specifically binding selected molecules to either a synthetic heteropolymer or a multivalent heteropolymenc hybnd structore compnsing a suitable defined sequence segment capable of hybndization. The synthetic heteropolymers, multivalent heteropolymenc hybnd structures and multimolecular heteropolymenc complexes of the present invention can be added to a reaction mixture directly, incorporated into a device, or they may be capable of attaching to solid supports and matnces including, but not limited to, thin and thick films, lipid bilayers, microvesicles, membranes, organic pohmers, microparticles, and inorganic substrates such as silicon, silicates, plastics, polymers, graphite and metals They may be immobilized by covalent attachment, adsoφtion, controlled deposition or affimty -based methods such as hybndization. Immobilization may also be achieved by in situ synthesis of constituent synthetic heteropolymers or linker oligonucleotides on suitable substrates followed by in situ self-assembly of multivalent heteropolymenc hybnd structures or multimolecular heteropolymenc complexes. The proximity of the selected defined sequence segments to one another withm the synthetic heteropolymer or multivalent heteropolymenc hybnd structore, which is controlled by the length, composition and three-dimensional structure of the spacer nucleotide and linker ohgonucleotide sequences, is such that the binding of a molecule at one defined sequence segment can modulate the affimty of another defined sequence segment for a second nonoligonucleotide molecule. Modulating the affimty refers to any increase or decrease in the association or dissociation rate constants that charactenze the binding between a defined sequence segment and its specific binding partner. The binding of a molecule at one defined sequence segment can also modulate the activity of a molecule bound to another defined sequence segment. Modulating the activity refers to restoration, transduction or elimination in part or in full ot the biological, chemical, optical, catalytic, mechanical, electncal or electrochemical activity of a selected molecule or nucleic aαd sequence. For example, in a diagnostic assay, specific binding ot a nonoligonucleotide molecule such as a receptor or ligand to a second defined sequence segment of a synthetic heteropolymer may decrease the binding affinity of a first defined sequence segment for a bound, inactive or partially inactive molecular effector. This results in displacement of the molecular effector and restoration of its activity Thus, the presence of the selected receptor or ligand may be momtored by measunng activity of the molecular effector. In the case of a selected nucleic aαd sequence, activity refers either to catalytic properties (e.g., πbozyme or catalytic DNA activity) or to information content (e.g., coding or regulatory properties). Modulation includes effects on catalytic activity, replication, transcnption, translation and enzyme-dependent processes such as strand extension, hgation, amplification, and the like. The acti ity of a molecule specifically bound at one defined sequence segment can also modulate the affinity of a second defined sequence segment for a second nonoligonucleotide molecule. Local production of hydrogen ions by an enzyme specifically bound to one defined sequence segment, for example, can modulate the affinity of a second defined sequence segment for a second molecule by decreasing the microenvironmental pH surrounding the second defined sequence segment. Similarly, the activity of a nonoligonucleotide molecule specifically bound at one defined sequence segment can modulate the activity of a second molecule bound to a second defined sequence segment A specifically bound enzyme, for example, may generate any number of products, including hydrogen ions, electrons, photons, heat, substrates, prosthetic groups, cofactors or inhibitors, that can influence the activity ot a second bound effector either directly or through effects on the microenvironment. The occupation state of a ligand or receptor bound at one defined sequence segment can also modulate the affinity of a second defined sequence segment for a second nonoligonucleotide molecule or the activity of the second nonoligonucleotide molecule. Specific binding of a hgand bound at one defined sequence segment to its receptor, for example, can increase the dissociation rate of a selected second molecule bound to a second defined sequence segment through stenc or conformational effects. The activity of the second molecule can increase or decrease with dissociation, depending on its relative activity in the bound and free states. By positiomng molecules so that binding or activity at a first defined sequence segment modulates binding or activity at a second defined sequence segment, synthetic heteropolymers of the present invention can be used to functionally couple a first selected molecule or nucleic acid sequence to a second selected molecule or nucleic acid sequence. For example, a first signal-generating molecule such as a fluorophore can be functionally coupled to a second signal-generating molecule such as a second fluorophore (e.g., a donor or acceptor), a hght-dnven or bioluminescent enzyme (e.g., an ATPase or luciferase) or an artificial reaction center (i.e., a molecule capable ot photoinduced charge separation). Alternatively, a synthetic heteropolymer of the instant invention can be designed to specifically attach and properly onent a signal-generating molecule to an electromc or optoelectronic transducer (e.g., an amperometnc electrode or photovoltaic cell) so that the signal-generating molecule, preferably a particular region ol the signal-generating molecule (e.g., a photon-emitting chromophore or electron-donating redox center), communicates intimately with the device (e.g., by energy transfer or direct electronic coupling). A first defined sequence segment is selected to specifically bind the selected signal-generating molecule. A second defined sequence segment is selected to specifically bind or hybndize a selected molecule or nucleic acid sequence compnsing or immobilized to the device. A synthetic heteropolymer compnsing the two defined sequence segments, optionally separated by a spacer sequence, is then synthesized and used as a molecular template to specifically bind the signal-generating molecule within functional coupling distance of the transducer. In addition, synthetic heteropolymers of the instant invention can be used as molecular positioning devices to enable functional coupling between different molecules conjugated to selected molecules, nucleic acid sequences or defined sequence segments. For example, a first signal-generating molecule (e.g., a donor fluorophore or donor enzyme) conjugated to a first selected molecule (e.g., a peptide) can be functionally coupled to a second signal-generating molecule (e.g., an acceptor fluorophore or acceptor enzyme) conjugated to a second selected molecule, (e.g., dextran) wherein the first and second selected molecules are specifically bound withm functional coupling distance to first and second defined sequence segments of a synthetic heteropolymer or multivalent heteropolymenc hybnd structure designed to position said first and second selected molecules within close spatial proximity. Alternatively, one or more signal-generating species (e.g., donor or acceptor fluorophores or enzymes) may be conjugated to a selected nucleic acid sequence which is capable of hybndizing to a second defined sequence segment of a synthetic heteropolymer, enabling energy transfer or enzyme channeling between the conjugated selected nucleic acid sequence and one or more signal-generating molecules (e.g., donor or acceptor fluorophores or enzymes) conjugated to either 1) a first or second defined sequence segment of the synthetic heteropolymer, or 2) a selected molecule or nucleic acid sequence capable of specifically binding or hybndizing to a defined sequence segment of the synthetic heteropolymer. In a related mode of operation, a first signal- generating molecule which is conjugated to a selected molecule or nucleic acid sequence may be functionally coupled to a second signal-generating molecule which is specifically bound to a defined sequence segment of the synthetic heteropolymer or multivalent heteropolymenc hvbnd structure. It will be apparent to one of stall in the art that synthetic heteropolymers of the instant invention can be used to provide functional coupling betvv een selected molecules and nucleic acid sequences which are attached to the synthetic heteropol mer either covalently or noncovalently and either directly or indirectly, so long as at least one defined sequence segment of the synthetic heteropolymer is capable of specifically recogmzing a nonoligonucleotide molecule or conjugate. Heteropolymenc functional coupling ot the instant inv ention does not include the interaction between a nbozyme and its biological recognition site, i.e., the catalytic activity resulting from nbozyme-based recogmtion and cleavage of a biological nucleic acid sequence. Also outside the scope of the instant invention are nbozymes compnsing synthetic defined sequence segments that bnng the nbozyme catalytic element under allostenc control, i.e., by specific recognition of a selected molecule or selected nucleic acid sequence that regulates πbozyme catalytic activity. The synthetic heteropolymers, multivalent heteropolymenc hybnd structures and multimolecular heteropolymenc complexes of the present inv ention may be used in a vanety of applications hich will become apparent to those stalled in the art upon reading this disclosure. For example, the present invention may sene as a homogeneous nucleic acid probe diagnostic used to report hybndization reactions. Nucleic acid probes are single- stranded sequences of DNA or RNA that specifically hybndize to defined target sequences of nucleic acids in a test sample. DNA probes labeled with detectable markers such as enzymes, isotopes, fluorophores or chemiluminescent compounds, provide a useful means for detecting and quantifying selected nucleic acid sequences in biological samples. DNA probe diagnostics have yet to realize substantial commercial success, however, largely because the complexity of test protocols have precluded routine implementation in clinical laboratory settings. In addition, cunent DNA probe assays are substantially more time-, labor-, stall- and cost-intensive than the two dominant in vitro diagnostic modalities, climcal chemistry and immunodiagnostics. In general, present technologies for heterogeneous DNA probe diagnostics involve the following steps. Genomic, cellular or plasmid DNA is extracted from test samples. The DNA is denatured to yield single-stranded targets. Target sequences are then amplified by successive replication using methods such as the polymerase chain reaction (PCR) or ligase chain reaction (LCR). Amplified target sequences are immobilized, and labeled probes are hybndized to the immobilized targets. The immobilized probe-target hybπds then require separation from unbound probes and successive washing before the bound probes can be detected by addition of a signal generator. In accordance w ith the present invention, a vanety of homogeneous DNA probe reagents can be prepared utilizing synthetic heteropolymers w hich simplify this process. In the present invention, the term homogeneous, as contrasted with heterogeneous, refers to properties of assay reagents that eliminate the need for tedious separation and washing steps. In homogeneous assays, the activity of a signal-generating species, process, or detectable label is altered when a probe specifically binds its target. Specific binding can then be quantified without physically separating bound complexes from unbound reagents. In one embodiment, a multimolecular heteropolymenc complex compnses a synthetic heteropolymer ha ing an effector molecule specifically bound to one of the defined sequence segments. Examples of preferred molecular effectors include, but are not limited to, such detectable species as chromogemc, fluorescent, chemiluminescent, bioluminescent and electroactive substances and enzymes, more prefened enzymes being glucose-6-phosphate dehydrogenase (G6PDH), acetyl chohnesterase, glucose oxidase, β-galactosidase, lysozyme and malate dehydrogenase. The second defined sequence segment of the multimolecular heteropolymenc complex is capable of hybπdizing with a selected nucleic acid sequence. This defined sequence segment serves as a nucleic acid probe The multimolecular heteropolymenc complex may be incorporated into a dry-reagent test device, attached to a solid support to create an immobilized reagent or added to a liquid reaction mixtore. In this embodiment, the activity of the molecular effector is modulated by target hybndization at the second defined sequence segment. It will be appreciated by those skilled in the art that many permutations of a single-reagent homogeneous format can be developed by selecting different combinations ot molecular effectors and defined sequence segments The state of activity of a particular molecular effector depends on the binding locus, length and affimty of the selected defined sequence segment, which can be optimized for maximal target- dependent modulation. In another embodiment, the multimolecular heteropolymenc complexes of the present invention compnse a synthetic heteropolymer having a ligand specifically bound to a first defined sequence segment and a second defined sequence segment capable ot hybndization The multimolecular heteropolymenc complex may be attached to a solid support to create an immobilized reagent, incorporated into a dry reagent test device, or added to a liquid reaction mixtore In this embodiment, hybndization at the second defined sequence segment can modulate either the affimty of the first defined sequence segment for the ligand or the activity of the ligand, resulting in activation or inhibition of a molecular effector that is not a constituent of the multimolecular heteropoh menc complex. This same basic reagent composition descnbed for homogeneous DNA probe diagnostics can be used for pseudoimmunodiagnostic applications through modular substitution of the defined sequence segments. Homogeneous diagnostic assays employing molecular effector-ohgonucleotide complexes to detect nonoligonucleotide molecules represent a replacement technology for immunodiagnostics. The utility of this approach resides in its simplicity, ease of use, modular design and versatility. By selecting defined sequence segments that specifically bind the nonoligonucleotide molecules to be analyzed, hereinafter analytes, diagnostic reagents can be developed which function much like labeled antibodies but with a number of important advantages. Activation of a molecular effector, preferably an enzyme, bound at a first defined sequence segment by analyte binding at the second defined sequence segment provides for a homogeneous, single-step, single-reagent diagnostic test. In addition, labeling of the synthetic heteropolymer with the molecular effector is accomplished by self-assembly of specific binding partners, thereby precluding tedious and imprecise covalent conjugations. Development of new diagnostic products using the modular design approach requires only selection and optimization of one defined sequence segment of the synthetic heteropolymer The defined sequence segment that binds the molecular effector, the molecular effector itself, and any linker oligonucleotides are consened from product to product. This modular approach to product development is both efficient and economical. Unlike homogeneous immunoassays, which tend to be best suited for either large molecules or small molecules, the present approach provides a common reagent configuration and assay protocol for any class of analytes. These pseudoimmunodiagnostic compositions can be incorporated into any reagent dehvery system including, but not limited to, slides, cartndges, sensors, test tubes, microtiter plates and autoanalyzer reagent channels. In one embodiment of homogeneous pseudoimmunodiagnosti.es, low molecular weight analytes are detected ith high sensitivity in the following manner. A multimolecular heteropolymenc complex is prepared compnsing a synthetic heteropolymer or multivalent heteropolymenc hybnd structure with a reporter molecule, preferably a molecular effector, more preferably an enzyme such as G6PDH, specifically bound to one defined sequence segment and the hgand moiety of a hgand-carner conjugate specifically bound to a second defined sequence segment. Examples of analytes for which such a complex is useful include, but are not limited to, hormones such as thyroxine (T4) and tniodothyronine (T3), prolactin, cortisol, estπol, estradiol, progesterone and testosterone; therapeutic drugs such as theophylhne, digoxin, phenytoin, valproic acid, phenobarbital, antibiotics and immunosuppressants; and drugs of abuse such as THC, cocaine, PCP, opiates and amphetamines. Due to their low molecular weights, some of these analytes may not be as effective in modulating the activity of a molecular effector specifically bound to a synthetic heteropolymer as high molecular weight analytes such as proteins, immunoglobulins and cell surface antigens. The impact of specific binding of such low molecular weight analytes to a first defined sequence segment of a multimolecular heteropolymenc complex on the activity or affimty of an effector molecule specifically bound to a second defined sequence segment can be amplified through analyte-dependent displacement of a large hgand-carner conjugate from the first defined sequence segment. The homogeneous configurations of the present invention can be adapted for use with a wide range of reporter molecules. Examples of molecular effectors that can serve as effective reporters in a multimolecular heteropolymenc complex include, but are not limited to, fluorophores, phosphors, bioluminescent and chemiluminescent reagents, quenchable dyes, activatable dyes and enzyme-enhanced luminescent and fluorescent reagent systems. Homogeneous pseudoimmunodiagnostic configurations are therefore compatible with all existing and anticipated nonisotopic detection systems, including, but not limited to, spectrophotometers, reflectance photometers, luminometers, fluoπmeters, potentiostats, potentiometers, and confocal and fluorescent microscopes. Classes of analytes for which multimolecular pseudoimmunodiagnostic heteropolymenc complexes may be most useful include, but are not limited to- infectious diseases, including viral, bactenal and fungal antigens and antibodies against these antigens; endocπnology and metabolism, including thyroid and reproductive hormones, B\ , folate, fern tin, glycosylated hemoglobin, parathyroid hormone, calαtonin and cortisol; therapeutic drugs, including theophylhne, digoxin, phenytoin, valproic acid, phenobarbital, antibiotics and immunosuppressants; allergy and immunology, including allergen-specific IgE and autoantibodies; drugs of abuse, including cocaine, cannabinoids, phencychdine and amphetamines; cancer, including CEA, AFP, CA 125, CA 50, CA 19-9, CA 15-3, PAP and PSA, and cardiovascular disease, including apohpoproteins, fibnnogen, cardiac enzymes and lsoforms, tropomn, myosin light chains and myoglobin. Clinical chemistry tests relying on coupled enzyme reactions can also be performed efficiently and with high sensitivity through use of multimolecular heteropolymenc complexes. The benefits of using multimolecular heteropolymenc complexes over conventional reaction mixtures include increased sensitivity, reagent stability and reaction rates; decreased sample volume and reagent mass/test; and suitability tor direct signal transduction using immobilized multimolecular heteropolymenc complexes. The combination of homogeneous DNA probes, homogeneous pseudoimmunodiagnostic assays and coupled enzyme climcal chemistπes prov ides a umfied approach to the three major classes of in vitro diagnostics, thereby enabling development of a universal climcal analyzer through use of multimolecular heteropolymenc complexes. Synthetic heteropolymers are particularly attractive for development of integrated diagnostic platforms, e.g., multianalyte biosensors and biochip arrays, because multimolecular complexes compnsing each required type of effector or target specificity (i.e., for DNA probing, pseudoimmunodiagnostics and climcal chemistry) can be attached to a transducer surface using a single, common process, e.g., immobilization of oligonucleotides and/or hybndization of defined sequence segments. In this way, nucleotide-directed molecular assembly can be used to produce useful anays, e.g., ordered arrays of multimolecular complexes for diagnostics, drug discovery and or high-throughput screening, e.g., by patterning on a chip or transducer surface (e.g., a slide, cartndge, semiconductor or optoelectromc device) ohgonucleotide sequences compnsmg or complementary to defined sequence segments of nucleotide-based discrete structures, preferably synthetic heteropolymers or multimolecular devices. An in vitro diagnostic tool is just one of the many applications for synthetic heteropolymers, multivalent heteropolymenc hybnd structures and multimolecular heteropolymenc complexes. Molecular complexes compnsing multiple coupled effector molecules, such as enzymes, represent molecular processing compositions that can be applied to cost-effective biosynthesis, including the production of chiral drugs and intermediates, industnal production and processing, computer-aided metabolic simulation and development of artificial organs. The multimolecular heteropolymenc complexes descnbed for homogeneous diagnostic assays are special examples of stimulus-sensitive molecular effectors or molecular switches that can be applied to m vivo diagnostic imaging, implantable devices, biosensors and biochips, pharmaceuticals and drug delivery. Using a therapeutic enzyme as the molecular effector component of a multimolecular heteropolymenc complex, delivery of the activ e therapeutic can be tnggered by a specific binding event between an unoccupied defined sequence segment of the complex and a physiological receptor or pathological target. Examples of therapeutic enzymes include, but are not limited to, tissue plasminogen activase and streptotanase (for acute myocardial infarction and pulmonary embolism), superoxide dismutase (for oxygen toxicity in premature infants), DNAse (for cystic fibrosis and chronic bronchitis) and cerebrosidase (for Gaucher's disease). It will be appreciated by those stalled in the art that in addition to enzymes, a virtually limitless array of therapeutic effectors can be specifically bound in inactive or inaccessible form to one defined sequence segment of a synthetic heteropolymer or multivalent heteropolymenc hybnd structure such that activation occurs upon specific binding of a second defined sequence segment to a physiological receptor or pathological target Many diseases, syndromes and pathological processes are multifactoπal, suggesting the potential clinical value of combination therapies However, combination therapies present significant πsks in the form ot combined toxiαties and drug interactions. Major therapeutic development strategies aimed at increasing drug efficacy without concomitant increases in toxicity revolve around novel drug delivery and targeting approaches Therapeutic immunoconjugates for site-specific delivery of radioisotopes or cytotoxins have received a great deal of attention over the past decade. Fusion proteins compnsing a targeting moiety and a toxic moiety are also being developed for infectious diseases and cancer Synthetic heteropolymers, multivalent heteropolymenc hybnd structures and multimolecular heteropolymenc complexes enable novel approaches to combination therapies and targeted drug delivery that cannot be achieved using therapeutic immunoconjugates or fusion proteins. In simplest form, synthetic heteropolymers or multivalent heteropolymenc hybnd structures can be designed to specifically bind two or more neighboπng sites on a single pathophysiological target. Bifunctional heteropolymers, for example, can act upon: two sites on a single molecule, such as an enzyme or a receptor; two molecules in a single structure, such as two proteins in a multimolecular receptor- effector system or a viral nucleic acid sequence and an associated coat protein; or two molecules on different structures, such as cell adhesion molecules or receptors located on different cells. Although most ot these approaches are technically plausible with immunoconjugates, bispecific antibodies or fusion proteins, synthetic heteropolymers and multivalent heteropolymenc hybnd structures provide a number of advantages that render them substantially more useful. First, nucleotide sequences that make up the synthetic heteropolymers can be selected and synthesized with desired specificity and affinity for either specific nucleic acid sequences or nonoligonucleotide molecules. Second, unlike bispecific antibodies and therapeutic immunoconjugates, multivalent heteropolymenc hybnd structures can be conveniently engineered with three or more specific binding sequences. Third, synthetic heteropolymers and multivalent heteropolymenc hybnd structures can be synthesized by established chemical methods, obviating the technical challenges and uncertain outcomes of designer antibody and fusion protein production. Fourth, the spacing of multiple specific binding sequences in synthetic heteropolymenc and multivalent heteropolymenc hybnd structures can be rationally designed and controlled through systematic production and evaluation of structures composed of v aπable-length and v aπable composition spacer sequences and linker oligonucleotides. In addition to two-site therapeutic actions, a number of other drug dev elopment approaches can be pursued through nucleotide- directed molecular assembly. In a first embodiment, multimolecular heteropolymenc complexes are synthesized compnsing two or more specific binding sequences, wherein a therapeutic drug is specifically bound to a first defined sequence segment and the second defined sequence segment is capable of specifically binding to a therapeutic target This embodiment enables use of the specifically bound drug as a targeting agent for site-specific delivery of the unoccupied specific binding sequence or, alternatively, use of the unoccupied defined sequence segment for site-specific delivery of the bound drug. In either case, the combination of drug action and specific binding of the unoccupied defined sequence segment to a pathophysiologic target can produce therapeutic effects through two distinct mechamsms of action. For example, a therapeutic for HIV could compnse a multimolecular heteropolymenc complex having a protease or reverse transcnptase inhibitor specifically bound to one site of a synthetic heteropolymer with an FQV-specific DNA probe or antisense sequence as the second site. In a second embodiment, combination therapies relying on multimolecular heteropolymenc complexes compnsing a ligand, preferably a therapeutic drug, specifically bound to one defined sequence segment and a molecular effector, preferably an enzyme, specifically bound to a second defined sequence segment are synthesized. In this embodiment, a high-affinity ligand may be used to deliver the complex to a particular site where simultaneous actions of the ligand and the molecular effector yield an additive or synergistic therapeutic effect. An example of such a multimolecular heteropolymenc complex is an adenosine regulating agent such as Arasine™ (Gensia Pharmaceuticals, San Diego, CA) specifically bound to a first defined sequence segment with the enzyme tissue plasminogen activase or Activase™ (Genentech, San Francisco, CA) bound to a second defined sequence segment to yield localized thrombolytic and cardioprotective effects in penmyocardial infarction, coronary artery bypass surgery and angioplasty procedures. In a third embodiment, combination therapies relying on multimolecular heteropolymenc complexes compnsing different ligands, preferably drugs, specifically bound to different defined sequence segments of a synthetic heteropolymer or multivalent heteropolymenc hybnd structure are synthesized. Examples of pairs of ligands which can be bound to selected defined sequence segments of synthetic heteropolymers or multivalent heteropolymenc hybnd structures include, but are not limited to: a histamine Ho receptor antagomst such as Tagamet™ (SmithK ne Beecham Pharmaceuticals, King of Prussia, PA) and a proton pump inhibitor such as Losec™ (Astra AB Pharmaceuticals, Sodertalje, Sweden) tor the treatment ot gastnc ulcers; a histamine H j receptor antagomst such as terfenadine and a mast cell release inhibitor such as cromolyn sodium for the treatment of histamine-mediated diseases such as bronchial asthma; an interleukin such as IL-3 and a colony stimulating factor such as GM-CSF for treatment of leukemias, cerebral malaπa, leishmaniasis and allergic disorders such as bronchial asthma; and a P-glycoprotein inhibitor such as verapamil or cyclosponn and one or more chemotherapeutic agents such as 5-FU and levamisole to eliminate the πsks of multi-drug resistance while treating malignancies. It is preferred that the combination therapies discussed be administered in a tnggered release configuration, i.e., as a prodrug, wherein binding of a first defined sequence segment, as in the first embodiment, or specifically bound ligand, as in the second and third embodiments, to its therapeutic receptor releases or activates the hgand or effector specifically bound to a second defined sequence segment of a multimolecular heteropolymenc complex. For example, binding of the H2 antagomst Tagamet™ to a gastnc histamine receptor would result in release of Losec™ to the gastnc proton pump through a conformational shift in the multivalent heteropolymenc hybnd structore used to deliver the two drugs. In addition to the diagnostic and therapeutic utilities discussed, the present invention can also be utilized in a vanety of applications including, but not limited to: sequential, multistep enzymatic synthesis of a particular product or degradation or a toxic metabolite; coupling proteins to selectively or actively transport ions and metabolites; coupling cytochromes to transduce chemical energy by means of electron transfer-dependent oxidation-reduction reactions; coupling redox mediators such as ubiqumones, ferπαnium salts, rubidium, viologens, tetrathiofulvalene, tetracyanoquimdodimethane, N- methylphenazinium, benzoquinone or conducting polymers or orgamc conducting salts to transfer electrons between electroactive molecules such as redox enzymes and electrodes in bioelectromc and optoelectromc devices such as biosensors and biochips; coupling photoactive compounds such as fluorophores with other photoactive compounds or with redox proteins or enzymes for energy transfer devices and artificial photosynthetic systems; and coupling pro-drugs for staged-dehvery or tnggered acti ation. Medical applications that rely on ordered arrangements of one or more exogenously administered molecules with an endogenous pathophysiological target include, but are not limited to: targeting radioconjugates or radiochelates of gamma-emitting isotopes such as iodine- 131, iodine 123, ιndιum-111, technetium-99m and copper-67 to pathophysiological markers such as cancer antigens CEA, TAG-72, CA 125 and CA 19-9 for in vivo diagnostic imaging; targeting radioconjugates, cytotoxins or cytotoxic cells to disease markers for localized cell kill; and targeting drugs to pathophysiologic receptors to achiev e receptor-, cell- or tissue- selective therapeutic action. Nucleotide-directed enzyme assembly using multimolecular heteropolymenc complexes provides a general method for production of spatially ordered, cooperative multienzyme systems. Applications include, but are not limited to, production of chiral intermediates and chiral drugs, industnal biosynthesis and bioprocessing, diagnostics, detoxification and computer-aided metabolic simulation. Advantages over soluble multienzyme systems include control over the spatial arrangement of individual enzymes within complexes; control over protein- protein interactions, diffusion distances and diffusion times; direct channeling of the product of one enzyme to a proximate enzyme; increased efficiencies through preferential reaction withm the Nernst layer; protection of unstable intermediates; regulation of microenvironmental factors; control over the direction of thermodynamically unfavorable reactions; and enhanced enzyme stability. Of particular commerαal value, nucleotide-directed enzymatic cycling can be used to dπve NAD(P)H- and ATP-dπven biosynthetic reactions using catalytic amounts of expensive pyπdme nucleotides. In addition, multistep sequential reactions involv ing unstable intermediates can be efficiently coordinated through nucleotide-directed juxtaposition of participating enzymes. Sequential, multistep enzymatic synthesis refers to the conversion of an initial substrate into a final product through a senes of enzyme reactions, wherein each proximal enzyme generates a product that is a substrate for a subsequent enzyme reaction. Practical application of multistep enzyme systems to industnal scale production requires enzymatic cycling. This techmque has been developed for soluble enzymes and has stimulated intense efforts in the area of immobilized enzyme systems. For purposes of this invention, enzymatic cycling refers to the shuttling of oxidized and reduced forms of a coenzyme between two linked enzymes. This type of reaction scheme is useful for a vanety of applications. There are over 250 NADH-dependent dehydrogenases alone, not including NAD(P)H-dependent enzymes. Representative NADH-dependent dehydrogenases currently used in climcal, fermentation, food and environmental applications include, but are not limited to, alcohol dehydrogenase, 3α-hydroxysteroιd dehydrogenase, lactate dehydrogenase, malate dehydrogenase, glutamate dehydrogenase, glucose dehydrogenase, ammo acid dehydrogenase, tartrate dehydrogenase, 12α-hydroxysteroιd dehydrogenase, estradiol 17α-dehydrogenase, aryl-alcohol dehydrogenase and testosterone β- dehydrogenase. Extremely sensitive determination of either NAD(P)H or analytes can be achieved through enzymatic cycling. Concentrations of NAD(P)H as low as 10 " ^M can be determined by measunng formation of an NAD(P)H-dπven product, because the number of cycles per unit time depends on the initial concentration of pyπdme nucleotide. Since NAD(P) can be supplied to the cycling reaction by a wide v aπety of pyπdine nucleotide- requiπng enzymes, highly sensitive detection can also be achieved for any analyte that is a substrate of an enzyme that can be coupled to a cycling reaction. Enzymatic cycling reactions can also be used for removal of a toxic substance or unwanted inhibitor from a reaction mixture or biological sy stem. They can be coupled to a wide range of disαete enzymes or multienzyme reaction sequences to catalytically degrade a particular undesirable substance. Multienzyme systems simulating hepatic detoxification processes and renal denitnfication reactions, for example, represent enabling tools lor valuable biomedical devices. Possible applications include extracorporeal devices for patients with severe hepatic disease; enhanced renal dialysis through enzymatic removal of urea and other toxic metabolites; and in vivo detoxification through multienzyme drugs, implantable devices and artificial organs. The same pnnciples applicable to nucleotide-directed multienzyme assemblies can also be applied to development of labeling reagents for speαfic binding assays. Such labeling reagents can amplify a signal to improve the detection limit of a diagnostic assay or transduce a detectable signal into a different type of signal that can be measured using an alternative detection system. Examples of this transduction capability include conversion of: a product that absorbs ultraviolet light into a product that absorbs in the visible range; an electrochemically detectable product into a spectrophotometncally detectable product and vice versa; a spectrophotometncally detectable product into a luminescent or fluorescent product; light of one wavelength into longer wavelength light, thereby effectively increasing the Stoke's shift; and a product with a high detection limit into a product with a low detection limit. Nucleotide-directed molecular assembly provides a practical approach for the juxtaposition of different fluorophores with overlapping emission and absoφtion spectra Applications include diagnostics, artifiαal photosynthesis and optical signal processing. Conjugation of fluorescem, Texas red, rhodamine, phycobihproteins and other fluorophores to ligands and receptors provides a useful means to quantify specific binding reactions either directly or through fluorescence energy transfer. Application of fluorescence energy transfer to the development of self-organizing molecular photonic structures (Heller et al. (1993) Clinical Chemistry, 39:742) and artificial photosynthesis have also been proposed. Those skilled in the art will recognize that the general pnnαples of nucleotide- directed enzyme channeling and fluorescence energy transfer can be applied to the intercom ersion of chemical, electromagnetic, mechanical and thermal energy Contractile, secretory and transport proteins, for example, represent suitable mechamcal acceptors for chemical energy in the same way that cytochromes and chlorophyll sene as acceptors of electrons and photons, respectively, in oxidative metabolism and photosynthesis. The potential utility of synthetic heteropolymers. multivalent heteropolymenc hybnd structures and multimolecular heteropolymenc complexes encompasses all applications tor which the ordered aπangement of molecules enables or improves reactions and processes that do not proceed efficiently w hen such molecules are either randomly distnbuted or ordered in bulk. Other utilities for the present in ention will become obvious to those skilled in the art from this disclosure. The following examples illustrate certain aspects of the present invention and are not intended to limit the same. EXAMPLES Example 1: Multivalent heteropolymer ic hybrid structures with synthetic heteropolymers attached to DNA dendrimers A first 30-nucleotιde defined sequence segment capable ot specifically binding to prostate-specific antigen (PSA), a diagnostic marker for prostate cancer, is selected by repeated cycles of partitioning and amplification of progressively higher affinity nucleic acid ligands from a candidate mixture as descnbed by Gold et al., U.S. 5,270,163. A second defined segment is designed to hybndize to a region of the first of t o types of single- stranded arms (i.e , nucleotide sequences) of the outermost layer of a tour-layer DNA dendnmer (Polyprobe™ , Inc., Philadelphia, PA). A synthetic heteropolymer compnsing the first and second defined sequence segments separated by a 15-nucleotιde spacer sequence is synthesized using an automated DNA synthesizer (Applied Biosystems, Inc., Foster City , CA). This synthetic heteropolymer is then hybπdized to the four-layer DNA dendnmer at a molar ratio of approximately 3-10 moles of synthetic heteropoly mer per mole of dendnmer to form a multivalent heteropolymenc hybnd structure (i.e., a PSA-binding synthetic heteropoh mer-DNA dendnmer hybnd, wherein the DNA dendnmer is a second synthetic heteropolymer having first and second defined sequence segments capable of hybndizing to selected nucleic acid sequences). The resulting PSA-binding multivalent heteropolymenc hybnd structore can then be used without further preparation in PSA assays relying on secondary labeling reagents (e.g., labeled, biotinylated or digoxigenin-modified oligonucleotides), or signal-generating species can be directly incorporated into the structore to create a labeled pπmary detection reagent (cf. Example 2, \ ide infra). In an alternative mode of preparation, the first deiined sequence segment of the PSA-binding synthetic heteropolymer descnbed above is incorporated dunng the final stage of dendnmer polymeπzation rather than by hybndization of the synthetic heteropolymer to the completed dendnmer. The selected PSA-binding defined sequence segment is added to the dendrimer synthetic process during the final polymerization step either as a single- stranded defined sequence segment (i.e., "end") of an arm or as a double-stranded region (i.e., hybndized "middle") of two arms making up the partially double-stranded "monomer" used to assemble the outermost layer of the DNA dendrimer. Incorporation of this PSA- binding monomer yields a multivalent heteropolymeric hybrid structure having the specific binding capabilities of a first synthetic heteropolymer polymerized into a hyperbranched discrete heteropolymenc structure by means of a dendnmenc linker oligonucleotide. In a further modification of this approach, the PSA-binding synthetic heteropolymer is covalently attached to the 5' end of the outermost arm of the DNA dendrimer, rather than being attached by hybridization. Covalent attachment is accomplished either by enzymatic ligation or by heterobifunctional crosshnking to a 5'-termιnal amine linker. R-Phycoerythrin (R-PE; Sigma Chemical Company, St. Louis, MO) (or one or more alternative signal-generating species) is attached to either of the above PSA-binding multivalent heteropolymenc hybnd structures either by covalent crosshnking using bifunctional conjugation reagents (cf. Wong (1991), Chemistry of Protein Conjugation and Crosshnking, CRC Press) or by hybridization or specific binding of a second defined sequence segment of another, different synthetic heteropolymer having a first defined sequence segment capable of specifically binding R-PE (Example 2, vide infra). Example 2: Fluorescent multivalent heteropolymeric hybrid structures using dendrimers A biotinvlated oligonucleotide complementary to a 20 nucleotide sequence segment of the second of two types of single-stranded arms of the outermost layer of the four-layer DNA dendrimer is synthesized using biotin- 16-dUTP (Boehnnger Mannheim Corporation. Indianapolis, IN) in place of dTTP. This biotinvlated oligonucleotide is then hybridized to the PSA -binding multivalent heteropolymeric hybrid structure of Example 1 at a molar ratio of approximately 50-150 moles of oligonucleotide per mole of dendnmer. An excess of streptavidin-phycoerythrin conjugate (Pierce Chemical Company, Rockford, IL) is then specifically bound to the biotin moieties of the multivalent heteropolymeric hybrid structore, and the fluorescent product is purified by denaturing sucrose gradient centrifugation. The product is used as a high-intensity, high-sensitivity fluorescent labeled reagent for PSA screening or diagnostic testing, preferably in solid phase, immunochromatographic or homogeneous energy transfer assay formats. A functionally equivalent fluorescent PSA detection reagent that does not rely on avidin-biotin chemistry is produced in the following manner. A first defined sequence segment is selected (e.g., by methods described by Ellington et al. ( 1990), Nature 346:818- 822) for the ability to specifically bind R-PE with relatively high affinity (Kd < 100 nM). A second sequence segment is designed to hybridize to a region of the second of two types of single-stranded arms of the PSA-binding synthetic heteropolymer-DNA dendnmer hybrid of Example 1 (vide supra). A synthetic heteropolymer compnsing the first and second defined sequence segments separated by a 15-nucleotιde spacer sequence is then produced using an automated DNA synthesizer. This synthetic heteropolymer is then hybπdized at a molar ratio of 100/1 to the synthetic heteropolymer-DNA dendnmer hybnd oi Example 1 to yield a multivalent heteropolymenc hybnd structure compnsing a first (PSA-binding) synthetic heteropolymer and a second (R-PE-binding) synthetic heteropolymer connected by a dendnmenc linker oligonucleotide. In a modification of this example, the second defined sequence segment of the second, R-PE-binding synthetic heteropolymer is not designed to hybndize to the linker ohgonucleotide, but is instead selected for the ability to specifically bind to the outermost monomer strands of the PSA-binding synthetic heteropolymer-DNA dendrimer hybnd by non- Watson-Cnck mechanisms, e.g., through tπplex or quadruplex formation. In this manner, the R-PE-binding synthetic heteropolymer can be specifically bound to the PSA-binding synthetic heteropolymer-DNA dendnmer hybnd structure and subsequently dissociated from the remainder of the heteropoh mer-dendπmer structure without denatunng hybπdized defined sequence segments). Alternatively, a multivalent heteropohmenc hybnd structure is constructed from a first synthetic heteropolymer hav ing a first defined sequence segment capable of specifically binding R-PE and a second synthetic heteropolymer having a first defined sequence segment capable of hybπdizing to a nucleic acid target (e.g., a nucleic acid probe specific for a target RNA or DNA sequence of an infectious orgamsm or genetic marker). The second defined sequence segment of each synthetic heteropolymer is hybndized to a complementary single- stranded arm of the DNA dendnmer. The resulting product is a multivalent heteropolymenc hybnd structure hav ing an av ailable defined sequence segment capable of specifically binding R-PE w hich is attached v ia a DNA-dendnmer (i.e.. a linker ohgonucleotide) to an av ailable defined sequence segment capable ot hybndizing to a nucleic acid target (i.e., a selected nucleic acid sequence). Alternatively, a multivalent heteropolymenc hybnd structure hav ing R-PE-binding and PSA-binding defined sequence segments hybndized to a DNA dendnmer linker ohgonucleotide is prepared as follows. A first synthetic heteropolymer is synthesized with a first defined sequence segment selected to specifically bind R-PE, a 10-nucleotide spacer sequence, and a second defined sequence segment selected to hybndize to a segment of one of two outermost single-stranded arms of the DNA dendnmer. A second synthetic heteropolymer is synthesized with a first defined sequence segment selected to specifically bind PSA, a 10-nucleotide spacer sequence, and a second defined sequence segment selected to hybndize to a segment of the other outermost single-stranded arm of the DNA dendnmer. The PSA-binding synthetic heteropolymer is then hybndized to the DNA dendnmer at a molar ratio of three, and the R-PE-binding synthetic heteropolymer is added at a molar ratio of 50 per dendnmer. R-PE may then be specifically bound pnor to. dunng, or after addition of the multivalent heteropolymenc hybnd structure to an assay system. Nonnucleic acid dendnmers can also be used as linker oligonucleotides and/or assembly scaffolds by first attaching one or more selected nucleic acid sequences as follows. Generation seven poly(amιdoamιne) dendnmers having a molecular weight around 234 talodal tons and approximately 1024 terminal amine groups are synthesized by the divergent controlled method of Tomaha and Durst (Tomaha et al. ( 1993) In: Topics in Current Chemistry, pp. 193-245 Spπnger, Berlin). The polyamido dendnmers are then complexed by charge neutralization with a four-fold molar excess of a single-stranded 80mer ohgonucleotide compnsing an 18-nucleotιde synthetic heteropolymer hybndization sequence. A synthetic heteropolymer compnsing a first 30-nucleotιde R-PE-binding defined sequence segment, a 10-nucleotide spacer sequence, and a second 18mer defined sequence segment complementary to the hybndization sequence of the dendπmer-complexed oligonucleotide is then added at 109?- molar excess ov er the 80mer o gonucleotide. The solution is mixed thoroughly and left standing for two hours at room temperature. R-PE is then added stoichiometncally with v ortexing, the mixture is left standing for tvvo hours at room temperature, and the resultant R-PE-synthetic heteropoh mer-ohgonucleotide- dendπmer complex is puπfied over SEPHAROSE™ (beaded agarose; Pharmacia LKB, Piscata ay , NJ). Example 3: Multimolecular transducer comprising a fluorescent synthetic heteropolymer conjugate A 36-nucleotιde synthetic heteropolymer is synthesized having a first 3'-end 30- nucleotide R-PE-bindmg defined sequence segment (cf. Example 2, vide supra) and a second, noncomplementary 5'-end six-nucleotide defined sequence segment (ATTTGC) terminating in the 13-carbon, 5'-termιnal pnmary amine-generating reagent [N- tnfluoroacetamιdo-(3-oxa)-pentyi-N,N-dιιsopropyi-methyl]phosphoramιdιte (Boehnnger Mannheim Corporation, Indianapolis, IN). R-Phycocyamn (R-PC; absoφtion/emission maximum (Aπ^/Em a x)^ 17/640 nm; Sigma Chemical Company, St. Louis, MO) is covalently attached to the 5'-termιnal amine of the synthetic heteropolymer using the NHS- ester-maleimide heterobi functional crosshnking reagent SULFO-MBS (Pierce Chemical Company, Rockford, IL). The R- PC-synthetic heteropolymer conjugate is punfied by gel filtration using a P-100 column (Bio-Rad Laboratoπes, Hercules CA) and the molar concentration is determined by absorbance at 617 nm using a Shimadzu Model UV-160 recording spectrophotometer. An equimolar amount of R-PE (A ma /E max =565/578 nm) is then added, and formation of the R-PC-synthetic heteropolymer-R-PE multimolecular transducer is monitored by tanetic readings of 640 nm fluorescence following excitation through a 550/30 nm band pass filter using a FLUOSTAR microplate fluoπmeter (SLT Labinstruments, Research Tπangle Park, NC) and black FluoroNunc™ plates (Nunc, Inc. Napen ille, IL). Wells containing equivalent amounts of R-PE, R-PC and a random 36mer ohgonucleotide are used as negative controls. Only wells containing R-PE specifically bound to the R-PC-synthetic heteropolymer conjugate demonstrate time-dependent increases in fluorescence emission at 640 nm, indicating the presence of functionally coupled effector molecules. Functionally coupled R-PE molecules can be covalently attached to the R-PC- synthetic heteropolymer conjugate using the homobi functional crosshnking reagent, glutaraldehyde (Sigma Chemical Company, St. Louis, MO) Glutaraldehyde is added dropwise with v ortexing (0.025-0.107c final concentration) to the R-PC-synthetic heteropoh mer-R-PE mixture containing R-PE at a final concentration oi 0.10-1.0 mg/ml. After a 1-4 hour incubation at room temperature, the reaction is quenched with glycine, reduced with sodium cyanoborohydnde and puniied by gel chromatography. The Stokes shift of the resulting multimolecular transducer is approximately 75 nm nm). For use as a signal-generating system in fluorescent affinity - based sensors, specific recognition reagents can be hybπdized or co alently attached in a site-directed manner to nucleotides of the synthetic heteropolymer portion of the covalent R- PC-synthetic heteropolymer- R-PE transducer. Example 4: Binary switch using a tethered specific recognition device with two different fluorescent states The general case of the instant example is a tethered recogmtion dev ice ior use in diagnostics and drug discovery, particularh as a single pixel ot a multi-element array for high- throughput screening. Parenthetical details in the instant example relate to a specific dev ice designed tor serotonergic drug discovery. The tethered multimolecular device descnbed in this example is a multimolecular switch, more precisely a heteropolymenc multimolecular sensor, that happens to be attached and iunctionally coupled to a macroscopic device, e.g., an optoelectronic transducer. Although detecting, reporting or actuating the output of the heteropolymenc multimolecular dev ice can be achiev ed using a anety of different macroscopic transducers or actuators, e.g., a planar waveguide, charge- coupled dev ice, photodiode or photosensitive transistor, the instant example descnbes generation of an electronic signal through immobilization and functional coupling of the heteropolymenc multimolecular device to a fiberoptic waveguide that is, in turn, functionally coupled to photodiodes of a portable fluoπmeter (ORD Inc., North Salem, NH). The fluonmeter is equipped with removable, v aπable-wavelength excitation and emission filters. Fibers are mounted vertically in a flow cell having and perfused with buffer. Fluorescent light is collected and guided by the fiber and detected by photodiodes ananged so as to distinguish between surface-bound fluorescence (from smaller angles) and background light (from larger angles). Evanescent detection pnnαples for both planar waveguides (e.g., Badley, et al. (1987) Phil. Trans. R. Soc. Lond., 5376: 143-160) and optical fibers (e.g., Rogers, et al. ( 1992) In: Biosensor Design and Application (Eds. P.R. Mathewson and J.W. Finley ), Am. Chem. Soc. Symp. Ser., 511, Chapter 13, pp. 165-172) are well known in the art. The transducer in this example is the optical fiber operativ ely coupled through its evanescent field to photodιode(s) capable of generating an electromc signal (v oltage). A branched molecular scaffold compnsing a flexible polymer shaped like an inverted "T" (e.g., a synthetic heteropolymer compnsing three 30-nucleotide defined sequence segments, each having nucleotide spacers and a terminal linker group) is immobilized to an optoelectronic transducer (e.g., a silaruzed optical fiber capable oi evanescent coupling to a photodiode) with the crossbar of the "T" aifixed to the fiber (e.g., having 3' and 5' ends attached to silane amines). The immobilized crossbar of the "T" compnses two defined sequence segments: a first defined sequence segment between its 3' end and the branchpoint and a second defined sequence segment between the branchpoint and its 5' end. The trunk of the "T," compnsing a third def ined sequence segment (i.e., the tethenng sequence) is attached at its 3' end to the crossbar branchpoint, I e , the midpoint between the f irst and second detined sequence segments The 5' end ot the third defined sequence segment is cov alently attached to a "tethered" fluorescent donor (e g., a 0.04 micron diameter 488/560 nm (A. max /E max ) fluorescent latex microsphere (Molecular Probes, Eugene OR)) Covalently conjugated to the fluorescent donor v ia long-chain heterobiiunctional crosshnkers are two ligands, a serotonin analog (LI) and a DNP analog (L2) The first (e.g., 40-nucleotιde) defined sequence segment of the tethered device compnses modified nucleotides labeled with a first acceptor fluorophore (e.g., Cy3 (Amax/Ejnax = 550/570 nm); Biological Detection Systems, Pittsburgh, PA) and is selected to specifically bind LI (as well as serotomn) with relatively high atfimty (i.e , K > 10 7 M ~ l ) The second defined sequence segment compnses modified nucleotides labeled w ith a second acceptor fluorophore (e.g., Cy3.5 (Amax/Emax = 581/5% nm), Biological Detection Systems, Pittsburgh, PA) and specifically binds L2 (as w ell as DNP) w ith relatively low affinity (1 e . K < 10 7 M '1 ) In the basal or unstimulated state (i.e , in the absence ot a serotonergic drug candidate capable of binding the first detined sequence segment w ith high affinity ), the tethered donor fluorophore conjugate of the multimolecular dev ice is specifically bound through its first hgand (LI) to the (Cy3-labeled) f irst detined sequence segment. On excitation at 488 nm by an argon-ion laser, the donor fluorophore transfers energy to the first (Cy3) acceptor-labeled nucleotides of the first defined sequence segment which, in turn, emit photons detectable at 570 nm by evanescent tunneling to a photodiode compnsing a portable fluonmeter (ORD Inc., North Salem, NH) equipped w ith removable excitation and emission filters. In the stimulated state (i.e., in the presence ot a serotonergic drug candidate that specifically binds the first defined sequence segment w ith high affinity), the tethered donor fluorophore conjugate of the multimolecular dev ice is specifically displaced from the (Cy3-labeled) first defined sequence segment by the higher affimty serotonergic candidate and specifically binds the (Cy3.5-labeled) second defined sequence segment. With 488 nm excitation, the donor fluorophore of the tethered recognition device now transfers energy to the second (Cy3.5) acceptor-labeled nucleotides of the second defined sequence segment which, in turn, emit photons detectable at 596 nm. The presence and/or concentration of selected target(s) (e.g., serotonergic drug candidates) is determined as a function of first acceptor and second acceptor emission intensities by measunng fluorescence responses to 488 nm excitation with selected emission filters and signal processing algonthms. The resulting output of the tethered recognition dev ice is essentially that of a simple logic gate. If "target is absent," then signal - hv \ (i.e., 570 nm). If "target is present," then signal = hv 2 (i.e., 596 nm). A tethered recogmtion device for nucleic acid detection is similarly constructed by tethenng to the bivalent crossbar of the polymenc molecular scaffold an effector species, preferably a donor signal -generating species (e.g., a 488/560 nm fluorosphere), which is conjugated to two different oligonucleotides. The first donor fluorospherc-conjugated ohgonucleotide (oligo- 1) compnses a 28mer DNA probe complementary to a selected target sequence, e.g.. a relativ ely conserv ed sequence of the infectious organism. Chlamydia trachomatis. The DNA probe segment of oligo- 1 further compnses a 15-nucleotιde sequence capable oi hy bndizing to a first defined sequence segment between the 3' terminus and the branchpoint of the polymenc scaffold crossbar (i.e., conversely , this first deiined sequence segment compnses a 15-nucleotιde segment selected to hybndize to a region of the DNA probe sequence of oligo- 1). The second fluorosphere-conjugated ohgonucleotide (ohgo-2) comprises a 12-nucleotιde sequence capable of hybπdizing (optionally with one or more nucleotide mismatches) to a second defined sequence segment between the branchpoint and the 3' terminus of the polymenc scaffold crossbar (i.e., the second defined sequence segment and olιgo-2 are selected to hybndize with a lesser degree of complementaπty' than the first defined sequence segment and oligo- 1). As in the tethered specific binding dev ice of the preceding paragraph, each specific recognition site (i.e., defined sequence segment) of the polymeπc scaffold crossbar compnses nucleotides labeled w ith a different acceptor signal generating species. The first defined sequence segment is labeled w ith the fluorescence acceptor Cy3, and the second deiined sequence segment is labeled w ith the fluorescence acceptor Cy3.5. In the absence of the Chlamydia target sequence, the tethered donor fluorosphere of the multimolecular device remains hybndized ia oligo- 1 to the Cy3- labeled first deiined sequence segment of the crossbar. On excitation at 488 nm by an argon- ion laser, the donor fluorosphere transfers energy to the Cy 3 acceptor fluorophores of the first defined sequence segment. The excited Cy3 acceptors emit photons detectable at 570 nm. In the stimulated state (i.e., in the presence of the Chlamydia target sequence), the tethered fluorosphere-conjugated oligo- 1 is specifically displaced from the Cy3-labeled first defined sequence segment by more complementary hybridization between the 28mer DNA probe and Chlamydia target sequence. With oligo- 1 hybπdized to exogenous Chlamydia, the Cy3.5-labeled second defined sequence segment of the tethered recognition device becomes accessible to fluorosphere-conjugated ohgo-2. Hybndization of ohgo-2 to the second defined sequence segment results in fluorescence energy transfer from donor fluorosphere to Cy3.5-labeled nucleotides, resulting in laser-induced 596 nm emission. The presence and/or concentration of selected target sequences is thus determined by analyzing fluonmeter signals at 570 and 596 nm using selected optical filters, signal processing and data reduction routines. One potentially attractive commercial application ot tethered specific recogmtion pπnαples exemplified in the preceding paragraphs is a molecular counting dev ice, i.e. an array of multimolecular sensors capable ot detecting and quantifying v ery few molecules in v ery small sample v olumes, preferably ev en an indiv idual molecule in a nanohter or subnanohter v olume. Conventional affinity -based assays and sensors measure the concentration of an analyte by specific binding ot some fraction of analyte molecules within a sample (i.e . a percentage of analyte molecules determined by reagent and analyte concentrations, equihbπum binding constants and the reagent and analyte masses per test) Quantification relies on factory or operator calibration of the assay response (i e , signal) using ref erence standards (i.e., calibrators) compnsing know n concentrations ot analyte The molecular counting device, by contrast, is designed to bind essentially ev ery analyte molecule in a nanoscale sample v olume. The number of analy te molecules is counted by detecting a first signal conesponding to the number ot multimolecular sensors (i.e., tethered recogmtion devices) in the stimulated state and a second signal conesponding to the number oi multimolecular sensors in the basal state. The advantages of counting molecules rather than simply interpolating analyte concentration from a calibration cune will become progressiv ely more apparent as micromimatunzation (e.g., of combinatonal synthesis and high-throughput assays) creates new testing requirements (e.g., the need for analytical and QA/QC capabilities beyond the limits ot conv entional methods). Evolv ing analytical requirements include the ability to 1 ) reproduciblv measure ultralow analyte concentrations in ultralow v olumes (i.e., as tew as one molecule per umt v olume), 2) precisely measure ultralow deliv ered v olumes (i.e.. nanohter and ev en picohter v olumes) for quality control purposes, and 3) test and control cell-to-cell vanabihty in on-chip arrays. Tethered molecular recogmtion methods described in the instant example can be applied to the dev elopment of molecular counting devices capable of quantifying v ery small numbers of molecules (i.e., 1-100) in v ery small samples (i.e., picohter to nanohter v olumes). In a quality control mode, use of a calibrator solution compnsing a known concentration of a selected signal-generating species can be used to precisely measure the delivered sample v olume. Measured signal is a function of the product of the delivered v olume times the concentration of signal -generating species. Therefore, the delivered volume can be measured as a function of the measured signal divided by the known concentration of signal-generating species. The dynamic range of molecular counting devices can be further expanded through tabncation of transducers compnsmg massively parallel arrays ot multimolecular sensors (e.g., to create a "molecular abacus"). Tethered recognition devices illustrated in the instant example are adv antageously suited, e.g., for use in micromimatunzed diagnostic assay s and sensors, molecular sorting devices, high-throughput assays for screemng hbranes, (particularly highly diverse combinatonal libranes having only one or few copies ot each chemical entity ), biosensor and biochip anays, e.g., DNA chips for genomics, sequencing and drug discov ery . In an alternative embodiment from those descnbed in the preceding paragraphs, a paired catalytic recognition pair is used as effector. Dev ice construction is similar to the DNA probe and serotonergic drug screening systems (vide supra) with the following exceptions. First, pair enzymes are used as the dual signal-generating modality in place of two competing fluorescent energy transfer pairs. The signaling state of the paired enzyme system does not require either energy transfer or functional coupling bet een tvvo effector molecules Rather, a pair of enzymes (e.g., oxidase/ peroxidase, phosphatase/dehydrogenase) is conjugated and used a single effector pair tethered to the polymenc crossbar of the inverted "T" as abov e. Conjugated to at least the f irst enzyme is a hgand (e.g., a serotonin agonist or antagomst), adv antageously attached to the enzyme in a site-directed manner (e.g., Offord, R.E. ( 1990) In: Protein Design and Development of New Therapeutics and Vaccines (Eds. J.B. Hook and G. Paste), New York: Plenum, pp. 252-282; Fisch et al. ( 1992) Bioconjugate Chemistry 3: 147- 153). This ligand conjugated, tethered enzyme is specifically bound in the basal state of the switch to a heteropolymenc defined sequence segment that occludes the catalytic surface of the enzyme, rendenng it reversibly inhibited. In this basal state, signal can be generated only by the second (paired) enzyme. On binding of a high af finity serotonergic drug candidate, displacement of the serotomn-enzyme conjugate tnps the switch into its stimulated state, wherein the second enzyme is specifically bound in an inhibited state to a second, lower affinity (anti-enzyme) heteropolymenc detined sequence segment. Signal from the stimulated state can be generated only by the first enzyme, In this example, signal discπmination is based on the different, e.g., spectral or electrochemical properties of the tw o paired enzymes. The polymeπc wings ot the immobilized crossbar need not be labeled or othenvise modified. Tethered dev ices compnsing enzymatic effectors are particularly well suited for solution phase applications. Tethered and tnggered release drug deliv ery systems compnsing unpaired therapeutic enzymes are descnbed elsewhere in the instant specification. Example 5: Soluble tethered specific recognition device Tethered recognition devices rely upon specific recogmtion between at least two binding partners pseudoirreversibly attached to one another w ithin a single discrete structure, molecule or complex. The molecular scaffold compnsing the discrete structure, molecule or complex may be insolubilized or immobilized, e.g., by attachment to a solid support (as descnbed in Example 4, vide supra). Alternatively, tethered recogmtion devices may be dispersed, dispersible or soluble in a particular fluid or solvent. An important property of soluble tethered recogmtion devices (e.g., soluble multimolecular sensors) is homogeneous signal generation and therefore homogeneous detection. Homogeneous detection or stimulus-response coupling means that a specific recognition ev ent (i.e., stimulus) influences the activity of a signal-generating species, providing a detectable signal (i.e., response) without need for physical separation of bound from free fractions. Soluble tethered recogmtion devices enabling homogeneous detection of selected molecules or selected nucleic aαd sequences may be configured as follows. For detecting a selected molecule (e.g., a drug candidate, clinical analyte, or a ligand or receptor of agncultural, env ironmental or military interest) or a selected nucleic acid sequence (e.g., an infectious agent or a genomic, cellular or plasmid nucleotide sequence) a heteropolymenc sensor is constructed with (a minimum of) tvvo defined sequence segments. The first defined sequence segment is covalendy attached to an effector species, and the second defined sequence segment is capable of specifically binding the effector species. For example, a first defined sequence segment capable of specifically binding HIV-1 rev erse transcnptase (HIV- RT) with nanomolar affimty (K > 10° M " l) is selected from an RNA library . A second defined sequence segment capable of specifically binding and inhibiting the effector enzyme AP (Ki > lθ6 M " 1 ) is selected from a second RNA library . A 5'-bιotιnylated synthetic heteropolymer compnsing the first defined sequence segment at the 5' end and the second defined sequence segment at the 3' end, optionally separated by one or more nucleotide spacers, is prepared on an Applied Biosystems (Foster City CA) synthesizer using 5'-bιotin phosphoramidite from Glen Research (Sterling VA). Streptav ldin-AP is then specifically (and pseudoinev ersibly ) bound to the biotinvlated synthetic heteropolymer, and the product is puπfied by gel filtration using a Bio-Rad P-100 column (Bio-Rad Laboratones, Hercules CA). Effector AP activity is assayed kinetically in 96-well plates using 4-mtrophenyi phosphate for photometnc detection at 405 nm or ATTOPHOS™ (substrate set; Boehnnger Mannheim Corporation, Indianapolis IN) tor 420/560 nm fluorescence detection. The AP- tethered, HIV-RT-binding synthetic heteropolymer is titrated by photometnc assay to undetectable levels and then assayed in the presence and absence of isolated HIV-RT. An HIV-RT-dependent signal can be detected both photometπcally and fluoπmetπcally against buffer controls and normalized reagent controls (compnsing AP plus AP-binding ohgonucleotide). In an alternativ e embodiment of this approach, the second defined sequence segment capable oi specifically binding and inhibiting the etfector enzyme AP is not an aptamenc sequence, but a defined sequence segment compnsing a nucleotide ligand capable oi inhibiting the enzyme, i.e., a nucleotide analog or modified nucleotide compnsing an AP-inhibitory moiety with Kj > 10^ M " 1. An HIV-responsive DNA probe version of the two-segment tethered recogmtion device for detection of a selected nucleic aαd sequence compnsing HIV-1 is prepared as descnbed in the previous paragraph with the following modifications. An unbiotinylated, 5 '- amino-modified. 28-nucleotιde HIV-1 DNA probe sequence is substituted for the HIV-RT- binding first defined sequence segment. The biv alent synthetic heteropolymer is co alently attached v ia its 5'-amιno group (i.e., the first defined sequence segment) to AP using the bif unctional crosshnking agent SULFO-SMCC (Pierce Chemical Company . Rockford IL) according to the manufacturer's instructions. The AP-conjugated synthetic heteropolymer is punfied by gel filtration and assayed photometncally and fluoπmetncally for enzyme activity (i.e., inhibited state) and responsi eness to target (1 e., isolated, heat-treated HIV) as descnbed in the preceding paragraph. In an alternativ e embodiment of the homogeneous tethered recognition device, functional coupling between attached donor and acceptor effectors (i.e.. in the basal state) is used in place ot effector (e.g., AP) inhibition For example, a fluorescence energy transf er- based multimolecular sensor tor detecting HIV-RT is configured w ith a fluorescein-labeled HIV-RT-binding second deiined sequence segment (e g , using fluorescem phosphoramidite (Glen Research, Sterling VA) at a specif ic activ ity of six) capable of specifically binding and transferring energy to the acceptor fluorophore. R-PE (Sigma Chemical Company , St. Louis MO). A first, 5'-amιno-modιtιed HIV-RT-binding detined sequence segment is covalently attached v ia its 5'-amιno group to R-PE using the bifunctional crosshnker SULFO-SMCC (Pierce Chemical Company , Rockford IL). A second, fluorescein-labeled R-PE-bindmg (K < 10 7 M "1 ) detined sequence segment connected to the first defined sequence, optionally separated by a nucleotide spacer, specifically binds R-PE so as to position attached fluorescem moieties ithin energy transferπng distance of the R-PE. In the absence oi HIV-RT, argon-ion laser excitation (i.e., 488 nm) oi the multimolecular sensor results in eiticient energy transfer from fluorescem to R-PE ith minimal detectable fluorescem emission. In the presence of HIV- RT, high-affinity specif ic binding ot the f irst def ined sequence segment to HIV-RT disrupts the interaction between the fluorescein-labeled second defined sequence segment and R-PE HIV-RT recogmtion is detectable either by an increase in fluorescem emission, a decrease in R-PE emission or some combination or algonthm ot the two signals. For detecting hybndization of a selected nucleic acid sequence, a fluorescence energy transter-based multimolecular sensor like the one descnbed in the preceding paragraph is prepared w ith a first defined sequence segment compnsing a DNA probe rather than an aptamer sequence. For example, R-PE is covalently conjugated to the 5' terminus of a 28-nucleotide 5'-amιno-modιfied iirst defined sequence segment capable oi hybndizing to a relatively consen ed HIV-1 nucleotide sequence. A second, fluorescein-labeled R-PE- binding defined sequence segment is connected to the first defined sequence, optionally separated by nucleotide spacers to facilitate specific binding to the conjugated R-PE. In the absence of HIV-1, intraheteropolymer specific binding results in efficient energy transfer trom fluorescem to R-PE. In the presence of HIV-1, hybndization of the probe sequence to its target is favored over intraheteropolymer specific binding, and energy transfer from fluorescem to R-PE is interrupted. Homogeneous multimolecular dev ices compnsing only tvv o defined sequence segments are the simplest possible heteropolymenc tethered recognition dev ices. In each configuration descnbed in the instant example, a first deiined sequence segment plays the dual role ot tethenng an effector to a second defined sequence segment and specifically recognizing a selected target molecule or nucleic acid sequence. In alternativ e configurations, ditferent detined sequence segments may be pretened or required tor the ditferent Junctions of a tethered recognition device, e.g., 1) pseudoinev ersible attachment of an effector, 2) tethenng (i.e., positiomng) the effector with respect to an effector-binding (e.g., aptamenc) sequence, 3) lntradev ice specific binding to a conjugated effector. 4) specific recognition oi a selected target molecule or nucleic acid sequence. Example 6: Heteropolymeric multimolecular device with two defined sequence segments connected by nonnucleotide linker For most applications, preierred methods tor producing synthetic heteropolymers include automated synthesis and biological methods, e.g.., using recombinant DNA procedures. Howev er, in some cases it is adv antageous to simulate the iunction or ev aluate the potential utility of a synthetic heteropolymer using tvvo or more defined sequence segments w hich are either readily available or can be convemently modified for a particular molecular assembly task. In such instances, it may be preferable to prepare a synthetic heteropolymer by less than ideal methods, e.g., by conjugating tw o defined sequence segments using cov alent or pseudoineversible means. Also, synthetic heteropolymers compnsing defined sequence segments joined by nonnucleotidic linkages and/or linkers (e.g., nonnucleotide spacer groups, molecules, or polymers) hav e utility in screening and analytical applications, e.g., to identify compounds or fractions hav ing a desired catalytic activ ity and/or selectiv ity. For example, a population, generation or library of enzymes created by site-directed mutagenesis or directed in vitro ev olution (e.g., random mutagenesis plus recombination) can be screened tor activ ity in cleav ing a bond connecting two defined sequence segments to w hich functionally coupled effectors are attached. A bifunctional synthetic heteropolymer capable of assembling R-PE and R-PC (Sigma Chemical Company , St. Louis, MO) into a functionally coupled multimolecular device is prepared by specific binding of two conjugated defined sequence segments as follow s. A first defined sequence segment specific for R-PE (cf. Example 2, vide supra) and further compnsing a the 5'-termιnal pπmary amine-generating reagent [N- tnfluoroacetamιdo-(3-oxa)-pentyl-N,N-dιιsopropyl-methyl]phosphoramιdιte (Boehnnger Mannheim Corporation, Indianapolis, IN) is synthesized using an automated DNA synthesizer (Applied Biosystems, Inc., Foster City, CA) and conjugated to streptavidin using the heterobifunctional crosshnker MBS (Pierce Chemical Company, Rocklord IL) according to the manufacturer's instructions. A second 3'-bιotιnylated, R-PC-conjugated six-nucleotide deiined sequence segment (5'-R-PC-ATTTGC-3'-bιotιn) is prepared as per Example 3 with biotin phosphoramidite (Glen Research, Sterling VA) at the 3' terminus. Equimolar amounts of the two conjugated deiined sequence segments (streptavidin- conjugated R-PE-binding and R-PC -conjugated biotinvlated sequence segments) and R-PE are mixed, incubated for four hours at room temperature and punfied by SEPHAROSE™ (Pharmacia LKB, Piscataway, NJ) gel exclusion chromatography. An endopeptidase-cleavable synthetic heteropolymer compnsing R-PE-bmding and R-PC-binding defined sequence segments attached by the tπpeptide glycyl-gly-glycine (gly- gly-gly or tnglyαne) is prepared as follows. A defined sequence segment capable of speciiically binding to R-PC is selected by iterative cycles ot partitioning and amplification of a library of ohgonucleotide sequences compnsing a randomized 30-nucleotιde region flanked by PCR pnmer sequences. The selected detined sequence segment with 5'- phosphomonoester end is then synthesized on an Applied Biosystems (Foster City CA) automated synthesizer. The C-terminal carboxyl group ot tnglycine is conjugated to the 5'- amino group of the amine-modified R-PE-binding defined sequence segment descnbed in the preceding paragraph (vide supra) using the heterobifunctional crosshnker l-ethyl-3-(3- dimethylaminopropyl)-carbodnmide (EDC; Pierce Chemical Company , Rockford, IL) according to the manufacturer's instructions. Following removal of excess reagent by elution of the tnglycme-conjugated R-PE- binding ohgonucleotide over a desalting column, the N-terminal glycine amine is reacted with the 5'-phosphate group of the R-PC-bindmg defined sequence segment using EDC in a pH 6.0 imidazole buffer to form the stable phosphoramidate conjugate. The R-PE-binding-tnglyαne-R-PC-binding synthetic heteropolymer is then dialyzed against phosphate-buffered saline and punfied by gel chromatography. Equimolar amounts of R-PE and R-PC are specifically bound to the synthetic heteropolymer to produce a multimolecular fluorescence energy transfer device w ith a Stokes shift of approximately 75 nm (Am a /Em a x =565/640 nm). This energy transfer transducer may be used as a cleavable reporter to screen enzyme libranes for endopeptidase or amidase activ ity. Alternatively, a covalent transducer assembly may be prepared with R- PC and R-PE crosshnked to their respective defined sequence segments of the synthetic heteropolymer, e.g.. by ultrav iolet irradiation (1.8 J, GS Gene Linker® UV Chamber; Bio- Rad Laboratones, Hercules CA) or by chemical crosshnking to thiol-modified nucleotides using a bifunctional crosshnking reagent (e.g., the pyndyl disulfide reagent SPDP; Pierce Chemical Company , Rockford IL). Example 7: Nucleotide-based multimolecular devices using two specific binding pairs for enzyme attachment Nucleotide-based molecular scaffolds can be used to build multimolecular switches, transducers and drug delivery systems by positioning selected molecules in suitable proximity to allow functional coupling between the molecules. In a prefened mode of operation, each of two specific binding pairs is positioned along a defined sequence segment by site-directed attachment or positionally defined incorporation of a ligand or receptor (or sequence-directed hybndization of an ohgonucleotide-conjugated ligand or receptor). Specific binding partners of the conjugated lιgand(s) and or receptor(s), typically effector molecules and more typically signal-generating molecules and/or drugs, are then attached (either simultaneously or sequentially) to assemble and operate the nucleotide-based multimolecular device. The instant example illustrates the preparation of multimolecular transducers and switches relying on nucleotide-dependent positioning ot effector molecules. Positioning is achieved by specifically binding a first effector-receptor conjugate to a first gand-modified nucleotide of a defined sequence segment and a second effector-receptor conjugate to a second hgand-modified nucleotide of the defined sequence segment, wherein the number of nucleotides between first and second ligands is selected to maximize the degree of cooperativity or competition between effector-receptor conjugates In the first example, a multimolecular transducer producing enzyme-dnven luminescence is prepared by nucleotide-dependent positioning and functional coupling of the enzymes horseradish peroxidase (HRP) and alkaline phosphatase (AP). In a second example, an immobilized multimolecular switch produces tvvo different fluorescent responses to laser excitation depending on w hether a stimulus molecule (e.g., an etfector- receptor conjugate or a selected target molecule) is present. For preparation of an enzyme-based chemiluminescent multimolecular transducer, the enzymes HRP and AP are used to transduce chemical energy into photons through the follo ing coupled reactions. HRP catalyzes the cleavage of the 1.2-dιoxetane substrate 4-[3- (4-hydroxy -2-methy lnaphthalene- 1 -phosphory 1 )pheny l]-4-methoxy spιro( 1 ,2-dιoxetane-3 ,2- adamantane (HMPPD) to liberate the product 2-methy lnaphthylquinone and 3-(2'- spιroadamantanane)-4-methoxy-4-(3"phosphoryloxy)phenyl-1.2-dιoxetane (AMPPD; Urdea et al., EPO 401 001). AP catalyzes the chemiluminescent decomposition of AMPPD, generating photons. A defined sequence segment compnsing a 20 base pair sy nthetic DNA duplex is prepared by hybπdizing a 5'-bιotιny lated 20mer deoxy ohgonucleotide (A-strand) to a 5'- digoxigenin-labeled complementary 20mer deoxyohgonucleotide (A'-strand). The A-strand is biotinvlated using 5'-bιotιn phosphoramidite (Glen Research, Sterling VA). Digoxigenin labeling of the A'-strand is performed using the GENIUS™ ohgonucleotide 5'-end labeling set (a digoxigenin-NHS-ester and 5'-AMINOLINKER; Boehnnger Mannheim Corporation, Indianapolis IN) according to the manufacturer's instructions. AP conjugated to sheep anti- digoxigemn (Boehnnger Mannheim Corporation, Indianapolis IN) and HRP conjugated to streptavidin (Pierce Chemical Company, Rockford IL) are specifically bound to their respective synthetic DNA -conjugated ligands (i.e., digoxigenin and biotin) by combining equimolar amounts of the effector-receptor conjugates with the hgand-modified defined sequence segment to produce a coupled effector nucleotide-based transducer. An uncoupled reagent control mixture is prepared by combining equimolar amounts of the two conjugated effectors w ith an unlabeled 20 base pair DNA duplex. Luminescence is determined in a Tropix luminometer with dioxetane indicator reagents, detection buffer and instrument settings (e.g.. photon integration time) as recommended by the manufacturer (Tropix, Inc., Bedford MA). The uncoupled reagent control mixtore (i.e., negative control) is titrated by doubling dilutions in indicator reagent-containing detection buffer to determine the threshold effector/duplex concentration below which the photon count rate is w ithin tvv o standard deviations of the mean count rate obtained with detection buffer alone (i.e., reagentless buffer control). The count rate of the nucleotide-based transducer preparation (i.e., anti- digoxigemn-AP, streptav ldin-HRP plus digoxigenin-modified and biotin-modified defined sequence segment) is then determined in quadruplicate over a three-log dilution senes spanning the detection threshold of the negativ e control. Subtracting count rates ot buffer control replicates f rom transducer dilutions, significant transducer luminescence is apparent ov er the entire range tested. At all points along the dilution curv e, count rates ot transducer dilutions significantly exceed negative controls, demonstrating nucleotide-dependent f unctional coupling of donor (HRP) and acceptor (AP) effector molecules. An aptamenc multimolecular transducer yielding enzy me-dnv en luminescence by nucleotide-dependent functional coupling between HRP and AP is produced as follows. Double-stranded DNA aptamer sequences with relatively high affinity tor HRP are identified by iterative rounds of in vitro selection and amplification of a DNA ohgonucleotide library compnsing a 28-nucleotide randomized region. Selected HRP-binding aptamers are further selected for the ability to bind HRP in the presence ot dioxetane indicator reagents (ct. preceding paragraph) w ith minimal enzyme inhibition (i.e., without reducing apparent Vmax or increasing apparent Km). A digoxigenin end-labeled 35-base pair DNA ohgonucleotide compnsing the selected aptamer sequence is then prepared enzymatically using terminal transterase to incoφorate digoxigenin- 11-dUTP (Boehnnger Mannheim Corporation. Indianapolis IN). HRP and anti-digoxigemn-AP are specifically bound to the digoxigenin- modified aptamer by mixing equimolar amounts of the aptameric digoxigenin- ohgonucleotide, HRP and anti-digoxigenin-AP in assembly buffer to form an aptamenc multimolecular transducer. Activ ity of the aptamenc transducer is determined by measunng photon count rates at doubling dilutions of the aptamer-effector assembly in detection buffer against negative controls (unmodified DNA ohgonucleotide plus effector dilutions) and buffer controls using a Tropix luminometer and dioxetane indicator reagents. For preparation of an immobilized multimolecular switch using fluorescent effector-receptor conjugates, APC and R-PE are used as signal-generating species capable ot evanescent coupling through an optical waveguide to a photodetector. A 3 '-carboxyl 24mer deoxyohgonucleotide prepared using a 3'-carboxyiate photolabile support (Glen Research, Sterling VA) is covalently immobilized through its 3 '-carboxyl and 5'-phosphate groups using a bifunctional carbodiimide crosshnker (EDAC; Pierce Chemical Company , Rockford IL) to amine groups of silanized 1x60 mm cyhndncal quartz fibers with polished ends. The immobilization is performed at room temperature in the dark with gentle shaking using carboxylated ohgonucleotide at 500 pmol/ml in a reaction mixture compnsing EDAC and p- mtrophenol each at 0.5 mg/ml. After two hours, ohgonucleotide-treated fibers are washed lour times with PBS-Tween® 20, blocked for one hour in PBS containing 0.5% BSA, and washed tvv ice more with PBS-Tween® 20 containing 0A 7c BSA (assembh buffer). A nucleotide-based multimolecular switch is prepared and hybndized to the immobilized ohgonucleotide as follows. A 24mer deoxy ohgonucleotide is biotinvlated at the 5'-penultιmate nucleotide position using biotin-dT (at nucleotide position 23 from the 3' end) and 5'-dιgoxιgemn-labeled using the GENIUS™ ohgonucleotide 5'-end labeling set (digoxigemn-NHS-ester and 5'-AMINOLINKER, Boehnnger Mannheim Coφoration, Indianapolis IN) in accordance with manufacturer instructions. The biotinvlated. digoxigemn-labeled 24mer diluted in assembly buffer is hybπdized to ohgonucleotide- modified fibers Fibers are then nnsed repeatedly in assembly buffer and transtened to a stenle, screw -capped 50 cc polypropylene centπfuge tube containing assembly butter. An indiv idual oligonucleotide-modified fiber is then remov ed, πnsed in buffer and dipped sequentially at 15 minute mten als into buffered solutions containing stepwise increasing concentrations of an anti-digoxin-f luorescein conjugate (anti-digoxin-FITC, Sigma Chemical Company. St. Louis MO) showing relatively high affinity lor digoxigenin. Dose-dependent binding of the anti-digoxin-FITC conjugate to the fiber-immobilized, digoxigenin-labeled ohgonucleotide is demonstrated using a previously descnbed fiber-optic evanescent fluorosensor apparatus (Rogers et al. (1989) Analytical Biochemistry 182:353-359) with excitation at 485 nm and detection at 510 nm (i.e., near the FITC emission peak). For example, using a portable fiberoptic fluonmeter equipped with aπable-w av elength excitation and emission band-pass filters (ORD Inc., North Salem NH), fibers are mounted ertically in a llow cell having a capacity ot 46 μl and perfused with PBS-BSA at a rate of 184 /d/minute. Fluorescent light collected and guided by the fiber is detected by photodiodes ananged so as to distinguish surface-bound fluorescence trom background light. E anescent detection methods exploiting total internal reflection properties ot optical waveguides are well known in the art (e.g., Badley, et al. ( 1987) Phil. Trans. R. Soc. Lond., B3 6: 143- 160). The nucleotide-based multimolecular switch in this instance is attached and functionally coupled to a transducer, i.e., the optical fiber operatively coupled through its evanescent field to photodιode(s) capable oi generating an electromc signal (voltage). Between FITC conjugate dilutions, the flow cell is washed with assembly buffer containing 1% SDS for two minutes followed by assembly buifer alone tor 10 minutes. Initial binding rates are determined graphically from stnp chart recordings of the fluorescence response (milhv olts v s. time). Having established a maximal fluorescent signal of approximately 8.5 V/fiber at 10 micromolar FITC conjugate, the fluorescence signal with binding of 10 micromolar FITC conjugate is then re-determined with excitation through a 550/30 nm band pass filter and detection at 575 nm (i.e., the emission peak of R-PE). The FITC conjugate- saturated fiber is πnsed thoroughly in SDS-free assembly buffer and dipped in a buffered solution containing 10 micromolar streptav ldin-R-PE conjugate (Pierce Chemical Company, Rockford IL). Binding ot the R-PE conjugate is demonstrated by a rapid rate response (milliv olts s. time) at 575 nm, reaching maximal voltage w ithin about two minutes. On re- measuring the FITC response of this fiber using 485 nm excitation and 510 nm emission filters (i.e., to detect bound FITC conjugate), the fluorescence signal is below 1 V/fiber, indicating that most ot the FITC conjugate has dissociated trom the liber. Concomitant binding of the R-PE-streptavidin conjugate and dissociation ot the anti-digoxin-FITC conjugate demonstrates the streptav ldin-responsiv e switching property of the nucleotide- based multimolecular dev ice. Nucleotide-dependent positioning of biotin and digoxigenin as descnbed in the abov e paragraph demonstrates the pnnciple of a nucleotide-based multimolecular switch relying on mutually exclusive binding ot anti-digoxin-FITC and streptav ldin-R-PE This mutually exclusiv e specific binding pnnciple can be reconfigured tor a v anety of applications, including, w ithout limitation, high-throughput screening ot chemical and biological libraries (e.g., f or drug discov ery or directed ev olution of enzymes for industnal use), clinical, forensic, v eterinary , agncultural and env ironmental diagnostics; or detection and/or momtonng ot pests, pesticides, ioodborne or bloodborne pathogens, hazardous w astes or chemical and/or biological weaponry. For example, a nucleotide-based multimolecular sw itch for drug discovery (e.g., to identif y potent receptor antagonists) can be configured much like the biotin- and digoxigenin-modified nuclcotidc-based switch described in the preceding paragraph. An agonist- and digoxigenin-modified nucleotide with neighboring agonist and digoxigenin moieties is first prepared as above. Anti-agonist antibody ( or punf ied receptor or receptor mimetic) is conjugated to a f irst ef fector (e.g., R- PE) and prebound lo the agonist-modified nucleotide. A second el lector conjugate (e.g., anti-digoxin-FITC) is included in the screening buf fer. In the presence ot a pharmacophore w ith an affinity tor the ohgonucleotide-bound receptor conjugate hich is higher than the anti-digoxin conjugate's aff inity tor its hgand (i.e., the crossreactant, digoxigenin), the detectable signal (e.g., fluorescence emission) is switched I rom emission by f irst effector (e.g., anti-agomst-R-PE) to emission by second effector (e.g., anti-digoxin-FITC) concomitant w ith anti-agonist conjugate dissociation and anti-digoxin conjugate binding. Aptamenc multimolecular sw itches for drug discovery can be prepared in a similar manner, wherein an ohgonucleotide is prepared with one or more hgand-modified nucleotides (e.g., agomst-modiiied or antagonist-modified nucleotides) within or attached to a reporter- binding aptamer sequence (i.e., an aptamer sequence selected to speciiically bind a signal-generating species such as a reporter enzyme (e.g., HRP) or fluorophore (e.g.. R-PE). In this case, the switch is prepared w ith a iirst effector conjugate (e.g., labeled anti-hgand antibody or anti- hgand receptor) prebound to a hgand-modified nucleotide of the aptamenc oligonucleotide, which may in turn be immobilized to a transducer (e.g., hybndized to an optical waveguide). The hgand-modified nucleotide is positioned within the aptamenc ohgonucleotide m such manner that the prebound, labeled anti-hgand conjugate stencally precludes specific binding between the aptamer and its target, w hich signal-generating species is included in the pharmacophore screening buffer. In the presence of a high-affinity pharmacophore, dissociation ot prebound anti-hgand conjugate enables the second effector (aptamer target) to specifically bind the aptamer sequence, sw itching the transducer output trom a first effector signal to a second effector signal. Example 8: Synthetic heteropolymers with hybridizable second defined sequence segments for conjugation and immobilization Nucleotide-directed molecular assembly prov ides a unify ing approach for combining hy bndization, specific binding and ef fector tunctions w ithm a single discrete structure, e.g.. a sy nthetic heteropolymer. multiv alent heteropolymenc hy bnd structure or multimolecular complex. A sy nthetic heteropol er, tor example, can be used to combine the specif ic binding properties of an aptameric first deiined sequence segment with the hybndization properties oi a second deiined sequence segment. A selected nonoligonucleotide molecule (e.g., an effector) specifically bound to the first defined sequence segment (and optionalh covalenth' crosshnked in place) can thus be endowed with the hy bndization properties of a nucleic acid (i.e., the second defined sequence segment) in a reproducible and positionally controlled manner. Alternativ ely , a hybndizable sequence can be endowed w ith specific binding and/or effector capabilities by incorporation within a synthetic heteropolymer compnsing an aptameric detined sequence segment capable of specifically binding an effector (i.e., an aptamer target) w hich i optionally crosshnked in place. Similarly , a deiined sequence segment capable oi molecular recognition (i.e.. hy bndi/ation or specific binding) can be adorned w ith etfector tunctions b} incorporation of said def ined sequence segment ithin a heteropolymenc discrete structure comprising a specificalh bound or hybπdi/ed selected molecule (e.g.. a drug or signal-generating species) or selected nucleic acid sequence (e.g., a πboz}me or catahtic DNA molecule). In a prefened aspect of the instant invention, the ability of a synthetic heteropolymer to hybndize to a selected nucleic acid sequence is used as a means ot attaching the sy nthetic heteropolymer to a selected nonoligonucleotide molecule (e.g., an effector molecule) by hybndizing the synthetic heteropolymer to an effector-ohgonucleotide conjugate. In another and related prefened aspect oi the inv ention, the ability of a synthetic heteropolymer to hybndize to a selected nucleic aαd sequence is used as a means of attaching the sy nthetic heteropolymer to a solid support, e.g.. by hybridizing the synthetic heteropolymer to an immobilized ohgonucleotide. Preparation oi a synthetic heteropolymer having a first defined sequence segment selected for the ability to specifically recogmze a selected target molecule (i.e., the cancer marker PSA) and a second defined sequence segment selected for the ability to hybridize the synthetic heteropolymer to an oligonucleotide-conjugated effector molecule (i.e., the signal-generating species. HRP) or to an immobilized ohgonucleotide is descnbed below. A synthetic heteropolymer is prepared and hybndized to a nonoligonucleotide molecule-ohgonucleotide conjugate in the following manner. A 24mer oligonucleotide is synthesized on an Applied Biosystems, Inc. (ABI ; Foster City CA) nucleic acid synthesizer using 5'-THIOL-MODIFIER-C6 (Glen Research, Sterling VA ) to introduce a 5'-thiol terminus. The enzyme HRP (Sigma Chemical Company, St. Louis MO) is conjugated to the 5'-thιol group of the oligonucleotide using the water soluble NHS-ester-maleimide crosshnker, SULFO-SMCC (Pierce Chemical Company . Rockford IL). The ohgonucleotide-HRP conjugate is punfied by gel filtration using a BIO-RAD P- 100 column ( 1.5 x 65 cm; Bio-Rad Laboratones, Hercules CA). A bifunctional synthetic heteropolymer hav ing a 30-nucleotide first defined sequence segment capable ot specifically binding PSA and a second 20-nucleotιde defined sequence segment capable oi hybridizing to the HRP- conjugated ohgonucleotide is prepared using the ABI synthesizer. The puniied HRP- oligonucleotide conjugate is then hybridized to the second deiined sequence segment of the PSA-binding synthetic heteropolymer, and the HRP-labeled hybrid is punfied by gel filtration using a P- 100 column. Alternati ely, the PSA-binding sv nthetic heteropolymer is added to a PSA assay reagent mixture, and the HRP-ohgonucleotide conjugate is added either during or alter the synthetic heteropolymer-PSA incubation step. Specific binding of the PSA-binding synthetic heteropolymer is determined by measunng HRP activ ity of either the bound or free fraction using colonmetnc. iluoπmetnc. or luminescent detection reagents (e.g., a chromogen. substrate, and/or enhancer system). In a prefened aspect of synthetic heteropolymer-direeted conjugation, a first effector molecule specifically bound to a iirst defined sequence segment is Iunctionally coupled to a second etfector molecule-ohgonucleotide conjugate which is hy bπdized to a second defined sequence segment ot the sy nthetic heteropoly er. For example, using AP and HRP as donor and acceptor enzymes of a coupled enzymc-dπ\ en chemiluminescent pair (cf. Example 7, vide supra), the following multimolecular heteropolymenc complex is prepared using a synthetic heteropolymer that specifically binds a first etiector (HRP) and hybπdizes an oligonucleotide-second effector (AP) conjugate. A tirst 30-nucleotide defined sequence segment amino-modified using A MI NO- MODIFIER C2 dT (Glen Research, Sterling VA) at nucleotide positions 2, 6, 10, 20, 24 and 28 (trom the 3' end) and 5'-amιno modified using AMINOLINKER (Boehnnger Mannheim Coφoration, Indianapolis IN) is selected for the ability to specifically bind HRP without inhibiting the enzyme (cf. Example 9. vide infra). A second 24-nucleotιde defined sequence segment is selected for the ability to hybridize a 5'-biotinyiated 28mer oligonucleotide specifically bound v la its 5'-bιotιn to a streptavidin-AP conjugate (Boehnnger Mannheim Corporation, Indianapolis IN). A synthetic heteropolymer compnsing the first and second defined sequence segments separated by nucleotide spacers is prepared using an ABI (Foster City CA) synthesizer. HRP is speciiicalh bound in excess and the AP-strepta idin/biotin-ohgonucleotide conjugate is then h}bndιzed dunng sequential two-hour incubations at room temperature in PBS-BSA buffer. Functional coupling ot the synthetic heteropoh mer-conjugated etfector molecules (i.e., HRP and AP) is demonstrated b} luminescent assav using dioxetane indicator reagents (Tropix, Inc., Bedtord MA) as descnbed in Example 7 (vide supra). For stable, long-term storage, the coupled enz}mes ma} be covalenth attached to the s}nthetιc heteropohmer (e.g., using the heterobifunctional crosshnker EDC, Pierce Chemical Compan} , Rockiord IL) or to one another (e g., using the homobiiunctional crosshnker glutaraldehyde (Sigma Chemical Compan}, St. Louis MO) f ollowed b} gel filtration and storage in PBS-BSA buf fer. In an alternative method of prepanng functionalh coupled HRP and AP etfector molecules, a s}nthetιc heteropohmer is prepared compnsing a first deiined sequence segment capable ot specificalh binding HRP, as in the preceding paragraph, and a second deiined sequence segment oi such length, preferabh about tvv o to 20 nucleotides and more preterabh about five to 10 nucleotides, to enable conjugation oi AP or, preferabh , a streptav idin-AP conjugate, within iunctional coupling distance of speciiicalh bound HRP The s}nthetιc heteropolymer is s}nthesιzed with either a 5'-amιno group using AMINOLINKER (Boehnnger Mannheim Corporation, Indianapolis IN) ior covalent AP conjugation or a 5'-bιotιn phosphoramidite (Glen Research, Sterling VA) for specific binding oi a streptav idin-AP conjugate (Boehnnger Mannheim Coφoration, Indianapolis IN) Alternativ eh , a s}nthetιc heteropohmer capable ot speciiicalh binding both HRP and AP ma} be prepared w ithout amino-modified nucleotides A multimolecular complex is then iormed b} incubating the s}nthetιc heteropohmer with equimolar concentrations ot AP and HRP in assembh butter (PBS-BSA) The specificalh bound en/} mes ma} then be covalenth attached to one another b} rapid conjugation, e.g., using a biiunctional crosshnking reagent such as glutaraldeh}de or, more preierabh , a photoactiv atable crosshnker with pulsed irradiation In this manner, homogeneous preparations oi coupled enz}me conjugates can be prepared using the s}nthetιc heteropolvmer as a bifunctional template to position precursor molecules tor selective conjugation, I e., selectiv eh tavonng formation ot one-to-one heteroconjugates. Templated conjugation prov ides a general method ior reproduαble, hιgh-}ield production oi well-defined conjugates w ith a specific activity oi one (i.e., each conjugate comprises a single donor molecule covalenth attached to a single acceptor molecule). Template-directed conjugation, i.e., using synthetic heteropolymers to assemble selected precursor molecules tor proximity -directed covalent conjugation ot selected molecular pairs (rather than relying on random molecular collisions in bulk solution), does not require use ot an activating or crosshnking reagent. Templated conjugation can be used, ior example, to accelerate the rate oi product formation trom spontaneously reactive species or transition states with relativ eh high energies ot activ ation. B} minimizing prefened intermolecular diffusion distances and maximizing the probabiht} of an energetically tav orable collision between two selected molecules, a heteropoh menc template can catalyze intermolecular reactions by effectively reducing the energy of activ ation for bond formation. A heteropolymenc template can theretore function much like a multisite enzyme in juxtaposing substrates and/or reactiv e intermediates and/or cofactors. coenzymes or prosthetic groups in facilitating covalent modification ot reactants, optionally aided by input of exogenous energy , e.g., heat or photoactivation or sonic energy . For example, enzyme- like oxidase or dehydrogenase activity can be simulated by a sy nthetic heteropolymer having a iirst deiined sequence segment capable of specifically binding a flav in or nicotinamide coenzy me (e.g.. FMN, FAD, NAD, or corresponding reduced coenzymes) and a second deiined sequence segment capable ot specifically binding a substrate (e.g., a sugar, amino acid, redox indicator or dye molecule). Similarly , a heteropolymenc template can be used to dehv er a preiened substrate and coiactor combination in suitable relative proximity to iavor activ ation of a particular enzyme w ith selected specificity w ithin a complex mixture comprising multiple related enzyme specificities, e.g., for selectiv e assay of a specific a dehydrogenase. esterase, lipase, transferase, glycosidase, phosphatase or protease activity within a biological sample. A relatively πgid heteropolymenc scaffold for assembly of functionally coupled enzymes is produced by selecting a first double-stranded HRP-bindmg defined sequence segment and a second 28-nucleotide defined sequence segment which is fully complementary to the 28mer ohgonucleotide moiety of an AP-ohgonucleotide conjugate. On specifically binding HRP to the double-stranded first defined sequence segment and hybndizing the AP-oligonucleotide conjugate to the second detined sequence segment, the resulting multimolecular complex compnses a fully double-stranded scaffold. An ev en more rigid and globular tertiary structure can be achieved, it desired, e.g., by including self- complementary , single-stranded defined sequence segments at either end of the synthetic heteropolymer, causing the nucleotide scaffold to told and self-hy bπdize. For hybndization of a synthetic heteropolymer to a solid support, an ohgonucleotide or plurality of oligonucleotides (e.g., an ordered set or random pool, a library, a cDNA array) is first immobilized to the solid support by covalent attachment, streptavidin/biotin chemistry or passiv e adsoφtion, optionalh followed by inadiation or chemical crosshnking. Oligonucleotides may be attached to wells of microtiter plates, for example, by passiv e adsoφtion, using coating methods well known in the art. To maximize hybndization efficiency and solid phase capacity, it is preferable to immobilize oligonucleotides in a nonrandom fashion and more preferable to link a particular nucleotide or functional group to the solid support, e.g., by specific binding of a 5'-bιotιnylated oligonucleotide to a streptavidin-coated plate as follows. A synthetic 28mer 5'-amιno- ohgonucleotide with 5'-amιno group introduced using AMINOLINKER (Boehnnger Mannheim Corporation, Indianapolis IN) is produced using an Applied Biosystems (Foster City CA) nucleic acid synthesizer. The ohgonucleotide is biotin lated at the 5' end using the long chain NHS ester of biotin, NHS-LC-biotin (Pierce Chemical Company, Rockford IL). The 5'-bιotιnylated ohgonucleotide is dialyzed extensively against PBS followed by gel filtration using a SEPHADEX G-25 column (crosshnked dextran, Pharmacia LKB, Piscataway, NJ). Punfied biotinvlated ohgonucleotide is specifically bound at 50 ng/well to black HuoroNunc™ 96-well plates (Nunc, Inc. Nape lle, IL) passively coated at 500 ng/well with streptavidin (Pierce Chemical Company, Rockford IL). Ohgonucleotide-treated plates are then washed extensively using a PBS-Tween® 20-BSA buffer. For membrane immobilization, unmodified ohgonucleotide is diluted seπally in PBS buffer and spotted on a nitrocellulose transfer membrane (Schleicher & Schuell, Keene NH) using a dot blotting apparatus (Hoefer Scientific Instruments, San Francisco CA). Covalent attachment to the solid phase is then achieved by UV irradiation or vacuum drying at 85_°C. The membrane is then blocked with a PBS-based blocking buffer containing 0.5- 1.0% BSA and/or nonfat dry milk and washed by repeated immersion in fresh PBS containing 0.1% BSA Immobilization to quartz optical fibers, polymer-coated indium phosphide photodiodes, latex microspheres and polystyrene beads is achieved by vaπations of antibody coating methods (cf. Example 9, vide infra), optionally including protein coimmobihzation (e.g., using BSA) and covalent fixation (e.g., using glutaraldehyde). Alternatively, end- modified (e.g., 3' or 5' amino-, thiol- or carboxyl-modified) oligonucleotides are covalently attached v ia the 5'-phosphate group or via added 3' or 5' amino. thiol or carboxyl groups using a suitable bifunctional reagent, e.g., a carbodiimide or NHS-ester-maleimide crosshnker For hybndization to an oligonucleotide-modified solid support, a synthetic heteropolymer is designed with at least one defined sequence segment capable oi specifically binding to a selected molecule (e.g., the effector molecule, HRP; the ligand PSA; or the receptor, anti-human IgG antibody) and at least one deiined sequence segment complementary to an immobilized ohgonucleotide. To prepare a heteropolymenc solid phase for serotonergic drug discovery, for example, the synthetic heteropolymer compnses a first 40-nucleotιde defined sequence capable of specifically binding serotonin with relatively high affinity, optionally including fluorophore-modified nucleotides as descnbed in Example 4 (vide supra), i.e., for detecting competition with labeled ligand binding by inhibition of fluorescence energy transfer. A second defined sequence segment of the synthetic heteropolymer is selected for the ability to hybndize to the HuoroNunc™ plate- immobilized 28mer ohgonucleotide descnbed above. The serotomn-bindmg synthetic heteropolymer (10- 50 ng in 100 μl PBS-Tween®-BSA) is then hybπdized via its second defined sequence segment to the immobilized 28mer ohgonucleotide in a two-hour, room temperature incubation with shaking. After hybndization, wells are decanted and washed twice with PBS-Tween®-BSA. The amount of hybπdized synthetic heteropolymer per well may be determined by measunng acceptor fluorophore emission in a fluorescence plate reader (SLT Labinstruments, Research Tnangle Park, NC). Alternatively, the amount of hybndized synthetic heteropohmer may be determined by titration w ith fluorophore-labeled serotomn analog (e.g., LI; cf. Example 4, vide supra) and unlabeled serotonin. Hybndization of synthetic heteropolymers to solid supports prov ides a conv ement method to functionahze surfaces with specific binding properties, e.g., for screening, selection, detection, momtonng, separation, isolation, punfication and charactenzation of selected molecules, samples, mixtures and libranes, e.g., clinical specimens, biological samples or combinatonal hbranes compnsing useful or informative ligands. receptors or effector molecules. For extremely sensitive detection ot selected nonoligonucleotide targets, synthetic heteropolymers may be used not only for the capture phase, but also as solution phase specific binding partners. Amplification of a sequence compnsing a target-bound synthetic heteropolymer (e.g., PCR, LCR or isothermal amplification of a target- specific defined sequence segment) can then be used lo detect trace amounts, even a single copy, of an identified nonoligonucleotide molecule. Solid phase synthetic heteropolymers further compnsing defined sequence segments selected as probes for selected nucleic acid sequences, preferably anays of heteropolymenc probe sequences, can be used for screening, selection, detection, momtonng, separation, isolation, punfication and charactenzation of selected nucleic acid sequences and samples, mixtures and hbranes, e.g., clinical specimens, biological samples or combinatonal hbranes compnsing useful or informative nucleic acid sequences. In a particularly prefened embodiment, detection is accomplished by means of one or more effector molecules (e.g., fluorophore(s), enzyme(s), luminescent and or electroactiv e species) specifically bound to heteropolymenc defined sequence segments. Example 9: Bispecific nucleic acid antibodies for drug delivery, specific binding and DNA probe assays Diagnostic and therapeutic applications of bispecific antibodies, fusion proteins (e.g., immunoadhesins) and immunoconjugates (e.g., immunotoxins) are being dev eloped to capitalize on the potential advantages of peptide-based reagents and drugs with dual specificities and or effector functions. Bispecific antibodies are immunoglobulins or immunoglobulin fragments designed, selected, rearranged or engineered to provide two different binding speαficities withm a single antibody molecule. Bispecific antibodies may exhibit greater target cell specificity than two monospecific antibodies. For some therapeutic applications, the Fc effector function of the bispecific antibody is required for climcal efficacy, e.g., to tπgger an immune response by taller cells bound via the bispecific antibody to a therapeutic target such as a tumor. Specific receptors for immunoglobulins are present on the surfaces of diverse cell types, including phagocytes, eosmophils, natural killer cells and macrophages. Binding of immunoglobulins to these specialized receptors is an integral part of the immune system response, directing such activ ities as phagocytosis, clearance of immune complexes and antibody-dependent, cell-mediated cytotoxicity. Immunoadhesins, also refened to a antigen fusion proteins, are fusion proteins combining the hinge and Fc portions of an antibody with the binding domains of a receptor. Immunoadhesins exploit both the natural affinity of a receptor tor its ligand and the effector functions of the immunoglobulin Fc region. Other fusion proteins, e.g., single-chain antibody fusion proteins, For other applications (e.g., specific binding assays) only the dual specificities achiev ed by combining two different antibody combining sites is functionally important. Fab fragment-effector fusion proteins and therapeutic immunotoxins, for example, combine tw o different binding specificities or a selected binding specificity with a selected effector i unction (e.g., cytotoxicity) which is different trom the parental antibody Fc function. The clinical potential oi the bispecific antibody approach has yet to be convincingly demonstrated. One reason for early failures has been the inability of bispecific antibodies, e.g., ot munne monoclonal ongin, to interact with human Fc receptors, which act as tngger molecules on taller macrophages. Also, bispecific antibody technology has suffered from lack of efficient preparation methods. Coexpression of two antibodies tends to result in low yields of the desired bispecific product, likely due to unw anted heavy and light chain pairings. Nucleotide-directed molecular assembly provides an efficient alternative to the design of bispecific drugs, imaging agents, reagents and dev ices (ret erred to herein as "bispecific nucleic acid antibodies") with greater flexibility and positional control in combining different speαfic recognition properties and/or effector functions than possible with bispecitic antibodies. Synthetic heteropolymers useful as diagnostic imaging and therapeutic agents, ior example, can be designed with a iirst deiined sequence segment selected to specifically bind a therapeutic target (e.g., a tumor marker, cell surface antigen, enzyme, receptor, v iral coat protein or bactenal cell wall) and a second defined sequence segment selected to bind an endogenous effector (e.g., a complement receptor, killer macrophage or cytotoxic lymphocyte) or a drug or imaging agent (e.g., a radioconjugate, cytotoxin, or cytokine). In vitro diagnostic assays can also be improved using bispecific nucleic acid antibodies, e.g., synthetic heteropolymers compnsing a first defined sequence segment specific for a clinical analyte and a second defined sequence segment specific for a signal-generating species. A bispecific nucleic acid antibody designed to improv e the sensitivity and reaction kinetics of a PSA tumor marker assay compared to a conventional enzyme-linked immunosorbent assay (ELISA) is prepared in the following manner. A first defined sequence segment is selected for the ability to specifically bind PSA (cf. Example 1, vide supra). A second 30-nucleotide defined sequence segment compnsing an amino modifier (AMINO-MODIHER C2 dT; Glen Research, Sterling VA) at nucleotide positions (from the 3' end) 2, 6, 10, 20, 24 and 28 and a 5'-amιno modifier at position 30 is selected for the ability to specifically bind HRP without inhibiting the enzyme (i.e., without significantly reducing Vmax or increasing Km). A synthetic heteropolymer (i.e., the bispecific nucleic acid antibody) is synthesized on an automated ABI (Foster City CA) nucleic acid synthesizer compnsing the first and second synthetic heteropolymers separated by a 10-nucleotide spacer sequence with AMINO-MODIHER C2 dT at nucleotide positions 8 and 10. To prepare a labeled PSA-binding assay reagent, HRP may be specifically bound at this point to the second defined sequence segment of the (PSA- and HRP-) bispecific nucleic acid antibody and crosshnked in place using the heterobifunctional crosshnker EDC (Pierce Chemical Company, Rockiord IL). The resulting HRP-bispecific nucleic acid antibody conjugate is puniied by gel filtration using a P-100 column (Bio-Rad Laboratones, Hercules CA). Alternatively, the bispecific reagent can be used in a single-step, simultaneous PSA specific binding assay using a puπfied anti-PSA monoclonal anti-human PSA capture antibody (Accurate Chemical & Scientific Coφoration, Westbury NY) passively adsorbed to wells ot IMMULON™-4 (Dynatech Laboratones, Chantilly VA) 96-well microtiter plates. Bnefly, the anti-PSA antibody is diluted to 10 ug/ml in 50 mM carbonate buffer (pH 9.6) and coated at 100 μl per well for four hours at room temperature. Plates are decanted, washed once by filling wells with assay buffer (PBS (pH 7.4) containing BSA at 1 mg/ml and TWEEN® 20 (Sigma Chemical Company, St. Louis MO)), blocked for 1 hour with 200 μ\ of assay buffer containing 5 mg/ml BSA, and washed five additional times with assay buffer. Bispecific nucleic acid antibody and HRP are then added in a total volume of 50 μl, and the assay is initiated with addition ot 50 μl samples containing varying concentrations of PSA (0.01 - 100 ng/ml). The assay mixtore is incubated for 1 hour at room temperature with shaking. Wells are decanted and washed twice with PBS. Bound HRP is detected kinetically after a five minute substrate and enhancer incubation using a microtiter plate fluoπmeter (SLT Labinstruments, Research Tnangle Park, NC) and black HuoroNunc™ plates (Nunc, Inc. Naperville, IL). A similar bispecific nucleic antibody approach is applied to DNA detection in the following manner. A first 5'-amιnated 24mer ohgonucleotide compnsing a four-nucleotide 3 '-end spacer sequence and a 20-nucleotide 5'-end DNA probe to a 46-nucleotιde target sequence of a bactenal (E. coli) DNA is immobilized at 50 pmol per well to IMMULON™ polystyrene 96-well microtiter plates (Dynatech, Chantilly VA) using ΕDAC (Pierce Chemical Company, Rockford IL) followed by washing and blocking as per the anti-PSA immobilization protocol. A synthetic heteropolymer is synthesized compnsing the following sequence segments separated by a lOmer spacer sequence: 1) as first defined sequence segment and spacer sequence, the 30- nucleotide HRP-binding, animated defined sequence segment and the 10-nucleotide aminated spacer sequence descnbed above, and 2) as second defined sequence segment, a second 24-nucleotide DNA probe to the 46-nucleotιde E. coli target sequence nonredundant (i.e., nonoverlapping) with the iirst DNA probe sequence. This DNA probe-spacer-HRP-binding synthetic heteropolymer is mixed with HRP and samples containing varying amounts of denatured E. coli DNA. The E. coli DNA assay is then performed using incubation, wash and detection steps as per the bispecific nucleic acid antibody-PSA assay protocol (vide supra). Alternatively HRP may be specifically bound and, optionally, covalently crosshnked to the first defined sequence segment of the synthetic heteropolymer (e.g., using ΕDC) pπor to assay, enabling use of a single conjugated detection reagent in place of two separate reagents. Although addition oi a single, conjugated HRP-synthetic heteropolymer reagent may be more convenient, simultaneous incubation oi self-assembling synthetic heteropolymer and signal-generating components may provide more rapid reaction kinetics and supeπor sensitivity. In vivo applications such as diagnostic imaging, therapeutics and drug delivery are also possible using bispecific antibodies, iusion proteins and related antibody conjugates, e.g., as anticancer drugs, antimicrobial and antiviral compounds, fibnnolytic agents and immune modulators. Antibodies and antibody fragments hav e been chemically conjugated to a number of therapeutic effectors, including plant-deπved, ammal-deπv ed and bactenal toxins (e.g., lectins, selectins, venom toxins, enterotoxins), enzymes, radionuchdes and cytotoxic drugs. Through chemical conjugation, otherwise ineffectiv e antibodies, fragments or MRUs may be equipped with potent effector mechanisms. Fragments conjugated to radioisotopes may be used for in vivo imaging or cancer therapy. However, chemical conjugation methods have drawbacks. They may be inefficient or give πse to unstable or inactive products, or they may alter binding specificities or effector functions of constituent molecules. Repeated cycles of antibody punfication, modification, and repunfication are time-consuming and expensive. Also, regardless of the degree of punfication and repunfication, immunoconjugates are not precisely deiined chemical entities, but are ty pically heterogeneous at the molecular level. An alternative to chemical coupling is creation of nov el recombinant proteins with antibody specificities (i.e., fusion proteins) by genetically linking antibody genes to sequences coding for nonimmunoglobuhn molecules, e.g., enzymes, cytokines or toxins. In Fc fusion proteins (i.e., immunoligands), the genes encoding a ligand (i.e., a peptide or protein) are genetically linked to sequences encoding an Fc region. (Fc-mediated effector functions may be avoided, e.g., by site-directed mutagenesis or by linking the ligand gene to a sequence coding for the constant region of an immunoglobulin isotype, such as IgG2). Antigen-binding fusion proteins (i.e., immunoadhesins) represent the converse of Fc fusion proteins, compnsing recombinant proteins formed by genetically linking the antigen-bindmg portion of an antibody to a receptor-binding ligand. Bispecific antibodies, also known as bifunctional antibodies, represent another alternative for combining two functions within a single therapeutic structure. Bispecific antibodies are capable of recognizing and complexing ith epitopes of two different antigens, e.g., a tumor cell surface antigen and an immune cell receptor as a means of targeting effector cells against the tumor. To circumvent drawbacks of chemical conjugation, most efforts to produce bispecific antibodies rely upon hybnd hybndoma approaches. Once the hybnd hybndoma cell line has been developed, the secreted bispecific antibody is punfied from other possible combinations of heavy and light chains, e.g., by isoelectπc focusing, ion-exchange chromatography or double-affinity chromatography Bispecific antibodies can be developed with a first specificity against a therapeutic target (e.g., a cancer antigen, viral coat protein, fibnnogen, platelet or endothelial receptor) and a second specificity against an endogenous or exogenous effector (e.g., an immune cell, cytotoxic, antineoplastic or antiinfective drug, radionuchde, chelating or photodynamic or hyperthermic agent). Howev er, hybnd hybndoma methods are time-consuming, labor-intensive and prone to low yields of the desired combination of heav y and light chains (e.g., < 10%) For imaging and therapeutic applications, bispecific nucleic acid antibodies represent an attractive alternative to bispecific immunoglobulin antibodies. Bispecific nucleic acid antibodies (i.e., synthetic heteropolymers) can be developed with any combination of desired specificities toward selected targets and/or effector species Unlike lmmunoglobuhn- based bispecific antibodies, synthetic heteropolymers can not only specifically bind, but also hybndize to selected targets (e.g., viral, bactenal, genomic or cellular nucleic acid sequences). Bispecific nucleic acid antibodies tor in vivo use typically compnse at least a first target-binding defined sequence segment that specifically binds or hybπdizes a pathological target (e.g., a cancer antigen, vascular lesion, microbial sequence, coat protein, surface marker or membrane receptor) combined with at least a second defined sequence segment capable of specifically binding an exogenous or endogenous etiector (e.g., a T cell, macrophage, cell surface antigen or complement receptor, a iibnnolytic, antineoplastic or antiinfecti e drug; a cytotoxin, cytokine, photodynamic or hyperthermic agent; or a contrast or imaging agent, radionuchde or chelator). For example, a bifunctional therapeutic for mounting an endogenous defense against HIV can be developed using a synthetic heteropolymer compnsing a first defined sequence segment capable ot specifically binding the gp41 antigen of HIV-1 and a second defined sequence segment capable oi specifically binding the Fc-gamma RI receptor site (pπmanly found on monocytes and macrophages). Alternativeh, HIV replication can be inhibited using a synthetic heteropolymer compnsing a iirst defined sequence segment capable of hybndizing to a selected nucleic acid sequence compnsing the HIV-1 inon and a second defined sequence segment capable oi specifically binding HIV-RT (and optionally a third defined sequence segment capable of specifically binding, e.g., the HIV-1 rev protein). For cancer imaging and therapy, a single-step, bifunctional, mix-and-use radionuchde preparation (i.e., prepare as needed, minimizing waste from isotopic decay) can be developed using a synthetic heteropolymer compnsing a first defined sequence segment capable of specifically binding CEA and a second defined sequence segment capable of specifically binding an ιndιum-111 chelate (for imaging) or, alternatively, a yttπum-90 chelate (for therapy). In a particularly prefened therapeutic embodiment (e.g., for anticancer or antiviral therapy), a first defined sequence segment of a synthetic heteropolymer specifically binds a selected target (e.g., Lewis-Y antigen for breast cancer), a second defined sequence segment specifically binds an exogenous effector (e.g., a hydrolyzable doxorubicin-peptide conjugate), and a third defined sequence segment specifically binds and activates an endogenous effector (e.g., the human Fc receptor of a killer macrophage). Optionally, this multimolecular drug deliv ery system may be designed as a tnggered-release multimolecular switch, i.e., a prodrug, w herein binding of the first defined sequence segment to a tomor cell or the third defined sequence segment to a macrophage stimulates local release of the doxorubicin-peptide conjugate. Provided released doxorubicin-peptide conjugate is internalized by lysosomes more rapidly than synthetic heteropoly mer-bound doxorubicin conjugate, this tnggered-release composition enables more ef f ectiv e cellular delivery of doxorubicin. In an alternative prodrug embodiment relying on a bispecific nucleic acid antibody, a targeted therapeutic enzyme is admimstered in inactive form and released and activated at the site of therapeutic action. A heteropolymenc multimolecular drug delivery system compnsmg a bispecific nucleic aαd antibody prodrug is designed as follows to transport carboxipeptidase G2 in inactive form to tumors of colon carcinoma patients and release the enzyme in active form on specifically binding CEA. First and second defined sequence segments are selected for the ability to specifically bind first and second nonoverlapping epitopes on CEA, each with very high affimty (e.g., >10 9 M "1 ). In other words, the two defined sequence segments specifically and tightly bind different regions on CEA in a noncompetitiv e manner. A third defined sequence segment is selected for the ability to specifically bind and inhibit the enzyme carboxipeptidase G2. A synthetic heteropolymer is prepared compnsing the carboxypeptidase G2-bιndιng defined sequence segment flanked by the two CEA-binding defined sequence segments in such manner that binding oi the two flanking defined sequence segments to tumor-associated CEA results in release and activation of carboxypeptidase G2. Example 10: Use of synthetic heteropolymers to detect membrane- immobilized oligonucleotides and proteins Synthetic heteropolymers can be used in a wide v anety of immobilized reagent formats, e.g., to detect and quantify oligonucleotides or nonnucleic acid analytes, to immobilize a first defined sequence segment (e.g., an aptamer sequence) by hybndization of a second defined sequence segment to a solid phase ohgonucleotide, to immobilize a multimolecular complex or to immobilize a multimolecular device compnsmg effector molecules functionally coupled to one another or to a transducer. Among the simplest embodiments of synthetic heteropolymer use in immobilized reagent formats are membrane detection applications, including DNA hybndization (Southern blots), RNA hybndization (Northern blots) and protein detection (western blots). Follow mg are examples of the use of synthetic heteropolymers and multimolecular complexes to detect membrane-bound nucleic acids and proteins. To demonstrate direct detection of an ohgonucleotide attached to a membrane, the ohgonucleotide is first senally diluted in PBS. Replicates of each dilution are applied to nitrocellulose membrane either manually or, preferabh, using a dot blot or slot blot apparatus designed for quantitative transfer (Hoefer Scientific Instruments, San Franαsco CA). Oligonucleotides are then covalently affixed to the membrane either by UV inadiation or drying in a vacuum oven (85 °C). Membranes are blocked with a PBS bloctang buffer containing BSA, nonfat dry milk and Tween® 20 and πnsed extensively in a PBS-BSA- casein-Tw een® 20 blotting buffer. A multimolecular complex is prepared compnsing a synthetic heteropolymer with HRP specifically bound and co alently crosshnked to the first detined sequence segment (cf. Example 9, vide supra), a 10-nucleotide spacer sequence, and a second (DNA probe) defined sequence segment capable of hybndizing to the nitrocellulose-immobilized synthetic ohgonucleotide. Blocked, washed membranes are immersed in a solution containing the HRP-synthetic heteropoh mer complex in blotting buffer and incubated with gentle shaking to allow hybndization. Blots are then washed extensively in a modified blotting buffer and developed using a reagent mixture containing peroxide and a precipitating chromogen (e.g., insoluble 3,3',5,5'-tetramethylbenzιdιne or 4- chloro-1-napthol). Binding of the multimolecular complex is detected by visual inspection. For quantitative determinations, blots may be scanned photometπcally. For maximal sensitivity, blots may be developed with fluorescent or chemiluminescent HRP substrates, enhancers or coupled enzyme reactions instead of a colonmetπc indicator and scanned, e.g , using a FLUOROIMAGER (Molecular Dynamics, Sunnyvale CA) or MULTIIMAGER (Bio-Rad Laboratones, Hercules CA). Alternatively, membrane-bound oligonucleotides are probed in a sequential, "fonvard sandwich" protocol using a first incubation with (ohgonucleotide and HRP)- binding synthetic heteropolymer and a second incubation with HRP followed by washing, enzyme development and scanning. In this protocol, blocked, washed, ohgonucleotide- spotted membranes are immersed and gently shaken in blotting buffer containing a DNA probe synthetic heteropolymer compnsmg a first defined sequence segment capable of specifically binding HRP and a second defined sequence segment capable of hybndizing to the nitrocellulose-immobilized synthetic ohgonucleotide (i.e., a DNA probe sequence segment) separated by a 10-nucleotide spacer sequence. The immobilized ohgonucleotide- synthetic heteropolymer hybnd complex is nnsed in modified blotting buffer to remove unbound and nonspeαfically bound synthetic heteropolymer. The resulting composition (a synthetic heteropolymer attached to a solid support by hybndization of one defined sequence segment to an immobilized ohgonucleotide and capable of specifically binding at another defined sequence segment to a nonoligonucleotide molecule) is a generally useful construct for endowing a surface with recognition properties, e.g., for use in solid phase assays, biosensors, biochips and molecular arrays for high-throughput screening and diagnostics. In the instant example, the recogmtion property introduced to the surface (nitrocellulose membrane) is specific binding of HRP, i.e. for detection of membrane-bound oligonucleotides. After nnsing to remove unbound mateπal, the membrane with HRP- binding synthetic heteropolymer hybndized to membrane-bound ohgonucleotide is incubated with HRP in blotting buffer, rinsed extensively in blotting buffer and developed according to procedures descnbed in the preceding paragraph. Detection of nucleic acid hybndization to an immobilized ohgonucleotide is accomplished as follows. PCR is used to synthesize a single-stranded DNA probe ohgonucleotide having a first 24-nucleotιde sequence (A') complementary to a target ohgonucleotide (A) and a second 24-nucleotιde sequence (B 1 ) capable of hybndizing a second, different nucleic acid sequence (B). The target ohgonucleotide A is senally diluted in PBS and immobilized to a nitrocellulose membrane by quantitative transfer followed by covalent attachment, blocking and washing as descnbed in the preceding paragraph. A synthetic heteropolymer is prepared with a first defined sequence segment capable of specifically binding HRP and a second defined sequence segment (compnsing nucleic acid sequence B) which is capable of hybndizing the probe ohgonucleotide sequence B'. The DNA probe ohgonucleotide is then hybndized via sequence A' with the immobilized target sequence A, and the membrane is washed in modified blotting buffer. The HRP-binding synthetic heteropolymer and HRP are then added, either sequentially or simultaneously. Alternatively, the synthetic heteropolymer and HRP are prebound pπor to assay, optionally followed by crosshnking HRP in place to produce a stable heteropoh mer- HRP conjugate. Blots are then washed extensiv ely in a modified blotting buffer and developed using a reagent mixture containing peroxide and a precipitating chromogen (e.g., insoluble 3,3',5,5'-tetramethylbenzιdιne or 4-chloro-l-napthol). Results are determined visually, by instrumented scanning. Synthetic heteropolymers and multivalent heteropolymenc hybnd structures may be used in DNA blotting (i.e., Southern blots), RNA blotting (i.e., Northern blots) and protein blotting (i.e., Western blots) by modification of methods descnbed in the preceding paragraphs. For Western blots, proteins are transferred after electrophoresis to a blotting membrane (e.g., nitrocellulose) using an electnc cunent. A selected protein is then detected using a synthetic heteropolymer or multivalent heteropolymenc hybnd structore having one defined sequence segment that specifically binds the selected target and another defined sequence segment that specifically binds or hybndizes the detection reagent (e.g., HRP or and HRP-ohgonucleobde conjugate). Extremely high sensitivity detection of protein targets can be achieved (e.g., <10 molecules) by extensively washing blots after the synthetic heteropolymer binding step and then amplifying a defined sequence segment compnsing the synthetic heteropolymer. Example 11: Use of synthetic heteropolymers in purifying selected molecules from complex mixtures Bifunctional synthetic heteropolymers capable ot speciiically binding a selected molecule and recogmzing a surface or surface-immobilized molecule, e.g., a structoral shape or solid phase ligand, receptor, polymer or biopol mer, prov ide a useiul and efficient means of isolating and punfying valuable molecules irom complex mixtures. For example, a bifunctional synthetic heteropolymer compnsing a first defined sequence segment capable of specifically binding a high-value biopharmaceutical product, e.g , α-interferon. salmon calcitonm, taxol, human growth hormone or follicle stimulating hormone, and a second defined sequence segment capable of speciiically binding an inexpensiv e polymer, preierably an insoluble or immobilized polymer such as dextran. agarose, or polyethylene glycol, can be used as a cost-effective and reusable punfication reagent. Alternatively, isolation oi related molecules trom a complex mixture, e ., a library , pool, biological sample or homogenate, can be achieved using a bifunctional synthetic heteropolymer compnsing a first deiined sequence segment selected for the ability to specifically recogmze a class of molecules (e.g., taxoids, sex steroids, opiates, interferons, α-subumt-compnsing glycoprotein hormones, homologous proteins, a iamily oi ligands interacting with a particular receptor (e.g., congeners or receptor agonists, antagonists and/or mixed or partial agonists or antagonists) or a family oi substrates, cot actors or coenzymes recognized by a particular enzyme or family of enzymes). The synthetic heteropolymer is first added to a biological mixtore or process stream compnsing the selected molecule or group or molecules of interest (e.g., the biopharmaceutical peptide hormone, calcitomn). After bulk-phase mixing tor tvvo to 24 hours at controlled room temperature, the synthetic heteropolymer- bound calcitomn is separated from the mixture using a poly mer matnx, e.g., beaded agarose, in either batch or column mode. The calcitomn is then dissociated from the matnx- bound multimolecular complex under nondenatunng conditions (e.g., salt or pH elution). and the separation support is regenerated by thermal or ionic dissociation oi the synthetic heteropolymer. Alternatively, processing conditions may be adjusted so that after unwanted constituents are removed (e.g., eluted, decanted and/or washed) from the punfication vessel, the synthetic heteropolymer-calcitonm complex is eluted as an intact multimolecular complex. The calcitonin-synthetic heteropolymer complex is optionally covalently stabilized (i.e., chemically crosshnked), e.g., to prepare a specific binding assay reagent or an affinity support ior calcitomn receptor. Alternatively, the multimolecular complex is subsequently dissociated, and the synthetic heteropolymer is recycled in downstream processing. A particularly prefened batch process is developed to capitalize on use of a synthetic heteropolymer as an affimty reagent capable of specifically binding the target biopharmaceutical molecule (e.g., calcitomn) in solution followed by hybndization of the resulting multimolecular complex to an immobilized ohgonucleotide. The first defined sequence segment of the synthetic heteropolymer is selected to specifically bind calcitomn with high affimty. The second defined sequence segment of the synthetic heteropolymer is selected for the ability to hybndize to an ohgonucleotide immobilized to crosshnked dextran in such manner that the column can be regenerated and the synthetic heteropolymer recycled, e.g., by heating and/or buffer washes. Alternatively, a column procedure can be used, wherein the synthetic heteropolymer remains hybπdized to the column support and the column is regenerated by vanable salt, buffer and pH washes Any number of popular separation media (e.g., membranes, hollow fibers, filtration media electrophoretic gels, and microparticles) to efficiently isolate and punfy different classes of molecules and groups of molecules, e.g., industnal enzymes, dyes, monomers and poly mers as well as pharmaceuticals, nutraceuticals, proteins, hpids, peptides, enzymes, hormones and other biologicals, including viruses, bactena and even plant and animal cells. In a particularly prefened type ot separation process, synthetic heteropolymers are used to copunfy multiple selected molecules, preferably multiple effector molecules, and more preferably multiple functionally coupled effector molecules, e.g., multiple enzymes, transport proteins, cytochromes or photosynthetic molecules compnsing a pathway , shuttle or supramolecular assembly , particularly a pathway or process involving interaction between soluble and membrane-bound effectors (e.g., cytosohc and/or extracellular effectors as well as membrane-associated proteins, hpids and/or complexes). Particular time, labor, equipment and cost savings can be achieved in processes requinng isolation of multiple selected molecules irom a single source or mixture (e.g., a biological pool, a tissue homogenate or a bactenal. iungal or algal culture), especially if the multiple selected molecules are to be reconstituted or assembled into a iunctionally coupled multimolecular structore or process, e.g., a multienzyme pathway or photosynthetic apparatus. Multiiunctional synthetic heteropolymers, multivalent heteropolymenc hybnd structures and discrete structures compnsing multiple nucleotide ligands and/or nucleotide receptors of the instant invention enable copunf ication ot multiple nucleotide-bound effectors, preferably in a functionally coupled form. In a particularly prefened mode of operation, copuπfied effectors are charactenzed and quantified in nucleotide-bound form by an assay that measures an output of the functionally coupled effectors. Example 12: Selection of a synthetic defined sequence segment for the ability to stabilize a peptide drug The commercial potential of biological molecules is often limited by instability in a particular environment, i.e., unacceptable or suboptimal half-life or shelf-hfe. Biopharmaceuticals for human, vetennary and agncultural use, for example, and selected, engineered or evolved biomolecules for use in sensor and semiconductor devices (i.e., biosensors and biochips) tend to be less stable under conditions of use than synthetic or inorganic counteφarts. To capitalize on the functional div ersity and efficiency of biological molecules as drugs, devices and machine components, there is a need to stabilize, insulate, protect or shield vulnerable groups from enzymatic, chemical and environmental degradation. Aptamenc and heteropolymenc multimolecular dev ices of the instant invention provide a means to stabilize specifically bound, fragile molecular effectors from attack by protecting vulnerable groups, sites or topological regions. Preparation of a protective aptamenc or heteropolymenc composition requires selection of a defined sequence segment capable of binding a selected effector molecule and shielding susceptible group(s) from chemical and/or conlormational modification under conditions ot use. For example, a defined sequence segment can be selected to bind a therapeutic peptide and attenuate peptide degradation under physiological conditions, thereby increasing the in vivo half-life and therapeutic efficacy of the nucleotide-bound peptide. The instant example descπbes selection of defined sequence segments capable of binding to and enhancing the stability of antiplatelet and antithrombotic peptides. e.g., the RGDS peptide SK&F 106760 (SmithKline Beecham, Philadelphia PA) or the Gp Ilb/IIIa receptor-specific chimenc Fab fragment anti-7E3 (CENTORX; Centocor, Malvern PA) Vascular thrombotic events associated with myocardial infarction, percutaneous transluminal coronary angioplasty (PTCA), stroke, penpheral artenal occlusion and venous thromboembohsm. among other conditions, cause significant morbidity and mortality. Intense antithrombin and antiplatelet drug development efforts are undenvay to reduce the incidence of thrombotic events. Because rethrombosis occurs in 15% to 35% ot treated patients, a major drug development focus for the treatment ot acute myocardial infarction is maintaining vessel patency following thrombolytic therapy Another major focus is reducing the incidence of restenosis following PTCA procedures from the histoncal rate ot about 30% Other important applications for antithrombin and antiplatelet agents include chronic maintenance of vessel patency following coronary artery bypass surgery and post- thromboembohtic stroke. Pharmacological approaches to thrombosis include prostaglandins, calcium channel blockers and antifibnnogen agents; antagomsts of platelet activating factor and glycoprotein (Gp) lb, lib and Ilia receptors; ticlopidine, which alters GP Ilb/IIIa receptor expression; and inhibitors of cyclooxygenase, thrombin, phosphodiesterase and thromboxane synthetase. Significant evidence indicates that fibnnogen binding to the platelet Gp Ilb/IIIa (adhesion) receptor is the final common pathway of platelet aggregation, suggesting the utility of effective Gp Ilb/IIa receptor antagonists. CENTORX (Centocor; Malvern, PA) is a chimenc anti-7E3 Fab fragment with Gp Ilb/IIIa receptor specificity. RGD and RGDS peptides bind the active site of the Gp Ilb/IIIa receptor through the adhesive protein recognition sequences Arg-Gly-Asp and Arg-Gly-Asp-Ser, respectively, which are essential for fibnnogen-receptor interaction. However, the clinical and commercial potential of such antibodies and peptides as antithrombotics is limited by their unacceptably short half-lives. Platelet Gp lb receptors interact with von Willebrand factor associated with damaged vascular endothehum to initiate platelet adhesion. Adhesion is followed by platelet aggregation which, in turn, leads to thrombus formation. Gp lb receptor antagonists may therefore intenupt thrombus formation at an earlier point in the pathologic cascade than Gp Ilb/IIa receptor antagonists. Administration of a drug specifically bound to an aptamenc or heteropolymenc defined sequence segment of the present invention can increase the circulating half-life and therapeutic efficacy of the drug, as exhibited by enhanced antithrombotic performance of a platelet receptor antagonist. For example, a therapeutic composition compnsing a platelet Gp Ilb/IIIa receptor antagonist (e.g., RGDS peptide SK&F 106760 (SmithKline Beecham; Philadelphia, PA), Bntistatin or Echistatin (both of Merck; Rahway . NJ)) specifically bound to selected defined sequence segments are administered penoperatively by intravenous infusion. A library of fluorescein-labeled RNA molecules compnsing a 35-nucleotιde randomized sequence flanked by PCR pnmer sequences is produced by transcnption of a corresponding cDNA anay. The receptor-specific chimenc Fab fragment antι-7E3 (CENTORX; Centocor, Malvern PA) is incubated with the hbrary for two hours at room temperature, and the mixtore is transferred to a screw-capped flask comprising cultured fibroblasts in human serum protem-supplemented growth medium. After 24- hours in a 37 °C, controlled CO 2 incubator, the medium is transfened to microfuge tubes and centnfuged at 8,000 x g for one minute to remove cells, aggregates and debπs. The supernatant is transfened to fresh microfuge tubes and fluorescein-labeled antι-7E3/nucleotιde complexes are separated from the remainder of the mixture by agarose-RGDS affinity chromatography (and/or ion-exchange chromatography) with fluorescence monitored in black HuoroNunc™ plates (Nunc, Inc. Napenille, IL) using a FLUOSTAR microplate fluonmeter (SLT Labinstruments, Research Tnangle Park, NC). Only aptamers that specifically bind the anti- 7E3 Fab fragment and protect from enzymatic degradation in enzyme-supplemented medium are isolated by the selection procedure. Unbound fluorescein-labeled RNA sequences, fluorescent nucleotide fragments, and anti-7E3-bmdιng nucleotides that fail to protect against antι-7E3 epitope modification in enzyme-supplemented culture are retained by the chromatography medium. In alternative selection procedures, mixtures compnsing antι-7E3 Fab fragment and cDNA- generated RNA libranes are subjected to heat-stress (85_°C overnight) and/or enzymatic treatment by panels of proteases, endopeptidases and exopeptidases. Complexes compnsmg stabilizing fluorescent aptamers are then identified by ion exchange chromatography or affinity chromatography using RGDS agarose as descnbed in the preceding paragraph. Selected aptamers are amplified by PCR and sequenced. Antι-7E3-bιndιng epitopes are assessed by structure probing. Relativ e affinity is determined in competitive binding assays (e.g., fluorescence polanzation, fluorescence energy transfer) using labeled anti-7E3. The relative protective utility of selected aptamers is determined by real-time and accelerated stability studies (i.e., in vitro, in culture and subsequently in animals). The selected aptamer(s) maximally effective in protecting antι-7E3 trom degradation in animal studies is scaled up for controlled safety and efficacy compaπsons using antι-7E3 administered alone v ersus antι-7E3 administered as an aptamer-antι-7E3 complex. Example 13: Selection of defined sequence segments capable of mimicking the specificity of a known receptor The adv ent of hybndoma technology in the mid- 1970s catalyzed the ev olution of an entire industry dedicated to screening, selection, charactenzation. scale-up, punfication, labeling and lormatting of monoclonal antibodies lor applications ranging irom climcal, academic and industnal research to in vitro diagnostics, in vivo imaging, immunoconjugate therapy and env ironmental, agncultural, military , w orkplace and ev en home testing. Hybndoma technology offers the potential to create a highly div erse v anety ot reagents with diffenng binding specificities. Antibodies with useiul specificities toward most haptens and antigens heretofore know n to be important diagnostically (i.e., those detected by FDA- approved in vitro diagnostic assays) are readily available as catalog items irom a large number of commercial suppliers. However, the structural attnbutes and potential constraints, limitations and/ or conditions of use tor immunoglobulin reagents are nomdeal for certain applications and preclusive for others. Potentially undesirable attnbutes of antibodies include, ior example, their relativ ely large size ( 160 kilodaltons), instability with prolonged storage at ambient or elev ated temperatures, structural v anabihty (i.e., carbohydrate composition and microheterogeneity), potential tor structural (i.e., genetic, conformational) dnit, and highly complex and unpredictable tertiary structure as a tunction of pnmary amino acid sequence. As detection, amplification and signal transduction technologies improve and trends toward mimatunzation continue to push formats toward the micron and even submicron scale, the performance of diagnostic technologies (e.g., sensitiv ity , specificity, precision, reproducibihty , shelf-life) are becoming progressiv ely more dependent on the molecular featores and properties of recognition and transduction reagents. For applications requiπng truly vell-charactenzed reagents, e.g., pure preparations of chemically deiined specific binding reagents whose function (e.g., binding assay performance, stability) conelates predictably w ith chemical composition and structure, antibodies are less than perfect. Achieving sensitiv e, specific, reliable and robust performance from antibody reagents of is particularly challenging in harsh, v olatile and/or anable environments or processes (e.g.. biological fluids, organic solvents, thermal cycling, freeze-drying, operating conditions within a machine or system and/or ambient indoor or outdoor conditions). Disadv antages oi antibodies as reagents, drugs and dev ice components include not only reliability , stability and shelf-life limitations. Antibodies are disadv antageoush' of relatively high molecular weight (e.g., 50-160 kilodaltons; 50-105 talodaltons tor Fab and F(ab')2 fragments) and size (i.e., about 14x10x4 nm 3 , tor IgG and 7x5x4 nm 3 for Fab 1 ), susceptible to proteolytic digestion, aggregation, microbial contamination, and are difficult to modify and'or conjugate at uniquely defined sites, except, e.g., at N-terminal and C- terminal ammo acids, poly-his regions, strategically located thiols and/or sites introduced by genetic modification. Also, because of potential genetic dnf t of hybndoma cell lines and/or storage instability of irozen antibody stocks, guaranteed sourcing and the secunty ot rare clones and secreted antibodies are nontπv lal issues. Nucleotides prov ide a number oi significant adv antages as ieedstock molecules ior the production of well-defined molecular recognition dev ices, particularly multisite nucleotides compnsing multimolecular dev ices. Not only do nucleotides prov ide a conv ement approach to self-assembly based upon predictable rules of base-painng, effectors can also be readily attached by noncov alent, rev ersible or quasirev ersible means (e.g., specific binding to defined sequence segments). Unlike antibodies, oligonucleotides can be readily synthesized by automated methods (e.g., a DNA synthesizer) and strategically modified at defined positions by incorporating or attaching different tunctional groups at defined positions. Oligonucleotides can also be conveniently and reproducibly conjugated or immobilized v ia defined groups, e.g., functional groups of modified and/or 5' and/or 3' terminal nucleotides Also, the geometry oi the DNA duplex is well defined, the nucleotide backbone may be extensively modified and sequences compnsing nucleotide reagents and dev ices can carry intormation useiul in directing sell -assembly , specific binding and enzymatic processes This last iniormational role ot nucleotides is particularly important in practicing nucleotide-directed assembly processes ot the instant invention, particularly template -directed assembly of useful multimolecular dev ices and drug dehvery systems Antibodies, particularly bispecific antibodies, can in certain instances useiully assemble tw o different molecules, e.g., an effector cell and a therapeutic target or a surface- bound analyte and a detectable reported molecule. Howev er, antibodies cannot be built to suit, conveniently modified at defined positions, assembled by predictable rules of association, produced by automated synthesis, subjected to extreme temperatures, stored as benchtop reagents, or, perhaps most important, archived simply as sequence code that can be communicated by phone, tax or modem from one laboratory to another, enabling turnkey synthesis of the chemically defined product anywhere in the world within a matter of hours. Nucleotides compnsmg synthetic heteropolymers of the instant invention, in contrast to antibodies, provide a general class of structures useful as bimolecular and multimolecular assembly templates. Templating (i.e., template-directed assembly ) in turn, is an effective techmque for mimicking the structural organization and efficiencies of biological systems, as apparent, e.g., in electron transport systems, hght-han esting antenna systems, biochemical amplification and feedback systems, e.g., metabolic and regulatory cascades, multistep enzyme and signal transduction pathways, immune and inflammatory responses, and the like. Commercial applications of template-directed multimolecular assemblies include, w ithout limitation, advanced matenals, dev ices and processes, e.g., smart pohmers and polymer-device hybnds; microelectronic, photonic and optoelectromc devices; industrial process control systems, enzyme reactors, chiral processes, and detoxification systems; diagnostic reagents, devices, biosensors and biochips; and multimolecular drugs, prodrugs and drug delivery systems. Templating offers a number of advantages for reproducibly constructing molecular-scale de ices. For example, template-directed assembly eliminates the need for covalent attachment ot effectors (or other selected molecules), a common source of heterogeneity in macromolecular conjugate preparations. Noncovalent effector attachment enables rev ersible or quasireversible stimulus-response coupling, an important feature of multimolecular dev ices, e.g., switches and sensors designed for repetitive activation and/or continuous momtonng. Effector molecules, complexes, supramolecular assemblies and even particles and dev ices ot v irtually any size, composition and structore can be reproducibly attached to templates by specific binding interactions, regardless of the number and diversity of functional groups. Specifically bound effector molecules remain chemically unmodified, obviating the nsk of ineversible functional damage. Also, effector molecules need not be punfied pnor to assembly, reducing processing time, labor, and materials costs and improving dev ice yields. Template-based multimolecular assemblies prepared by site- directed attachment oi selected molecules have uniform and reproducible supramolecular composition. They can be theretore be used (and documented) as chemically defined (e.g., ell-characteπzed) components for manufacture ot higher order dev ices and systems. Templating can also be combined with chemical, electromechamcal, and optical assembly and modification tools, including, e.g., crosshnking, use of deπv atized nucleotides, nucleotide analogs, nucleotide ligands and nucleotide receptors: use of scanning probe techniques such as AFM and scanning tunneling microscopy ; and use of lasers, e.g., for optical trapping, optical tweezers and the like. Nucleotides are particularly advantageous building blocks for template construction. Efficient, reliable and programmable synthetic ohgonucleotide production is routinely achieved on automated synthesizers amenable to large-scale, cost-effectiv e production. With cunent efforts to scale up ohgonucleotide manufacture (e.g., for antisense therapeutics) production costs are dropping at an accelerating rate. Also, nucleotide monomers and backbone-modified oligonucleotides have the potential to be stored and used more like benchtop chemicals than fragile biologicals. The combinatonal (i.e., sequence- related) and chemical (i.e., relating to backbone, nucleoside modifications and nucleotide analogs) div ersity of nucleotides provides broad recogmtion potential for specific binding and assembh of v irtually limitless combinations of molecules H}bπdιzatιon of complementan nucleotide sequences enables modular dev ice construction, i.e., efficient design and production b} synthesizing and assembling h}bndιzable components. Essentially, nucleotides are uniquely qualified ior self-assembly processes relying on both complementary base painng and ligand-receptor docking. Also, nucleotides compnsing assembly templates can be recycled (i.e., salvaged and reused w ith or without modification) by dissociation from specifically bound effectors. Further, the replicative properties of nucleotides enables development oi multimolecular dev ices that not only self-assemble, but also self-replicate Finally, manufactunng technologies for nucleotide template-based assembly already exist, e.g., methods for prepanng large arrays of (e.g., immobilized) nucleic acids for sequencing and diagnostic use. there is substantial and growing interest withm the semiconductor industry in fabπcation and commercialization of ohgonucleotide chips, e.g., to capitalize on the potential synergies betw een biotechnology and microelectronics For these and other reasons, it may be desirable for a number of applications to "transpose" the useiul binding specificity of an identified ("reierence" or "parent") receptor or ligand, e.g., an antibody , membrane receptor or therapeutic target (e.g., a coat protein, disease marker and or cell surface antigen) into a nucleotide sequence, preierably a defined sequence segment comprising a synthetic heteropolymer or an aptamenc or heteropolymenc multimolecular device, which displays the same useiul specificity , optionally a similar, related, antiidiotypic. idiotypic and/or more useful specificity, as the identified receptor or ligand. In other w ords, it may be useful to select an ohgonucleotide, e.g., irom a diverse mixture or library oi nucleic acids, based upon the ability of the ohgonucleotide to mimic the idiotypic or antiidiotypic binding specificity of an identified ligand or receptor. An ohgonucleotide that mimics the binding specificity of a selected ligand or receptor is also refened to herein as a ligand or receptor mimetic or a mimetic nucleic acid sequence. Once characterized (e.g., ior binding specificity and affinity, preferably following amplification) and sequenced, sequences w ith desirable binding specificities may be incoφorated as detined sequence segments into synthetic heteropolymers, aptamenc and heteropolymenc multimolecular dev ices disclosed herein. A particularly preferred technique for identifying a defined sequence segment with specificity that mimics a selected ligand or receptor is the ligand-receptor dissociation method, also referred to as ligand dissociation, receptor dissociation, or simply a dissociation or displacement method or assay. Oligonucleotides compnsing a diverse nucleic acid mixtore are selected based upon their ability to dissociate a ligand-receptor complex. Heterogeneous selection assays are prefened, wherein either the ligand or the receptor is immobilized to a solid support. The specific binding partner of the immobilized reagent (e.g., the receptor or ligand, as the case may be) is specifically bound to the immobilized reagent, and mimetic nucleic acid sequences are selected (i.e., by subsequent charactenzation) from those capable of competitively displacing said specific binding partner. Homogeneous (i.e., solution phase) selection methods can also be used, wherein members of a nucleic acid library competitively dissociate a soluble ligand-receptor complex. In a typical protocol ior selecting ligand or receptor mimetics. v anations in specificity and/or affinity of selected nucleotide sequences are evolved by iterative or stepvvise transitions in selection pressure, e.g., by substituting congeners or crossreactants for one or both members of the dissociable ligand-receptor pair, by changing the selection assay architecture (e.g., from immobilized ligand to an immobilized receptor or homogeneous format) or by changing the selection assay protocol, buffer composition or incubation conditions. The performance in a chosen assay oi a deiined sequence segment selected to precisely mimic the binding specificity of the model ligand or receptor is then used as a standard against which to compare the performance oi vanant sequences selected with overlapping, nomdentical specificities. Through iterative selection tor evolv ing specificities, it is ev en possible to identity defined sequence segments that specifically bind a selected target of the parent ligand or receptor in a manner that is noncompetitive with the parent. In other words, specificity migration enables the identification ot pairs or groups of deiined sequence segments that bind a selected target at fully redundant, concentπc, partially overlapping or even nonoverlapping target recogmtion sites. Refinement or migration of binding specificity (i.e., epitopic evolution and/or dnft) may be rationally influenced or directed, e.g., by chemically modifying a selected target in a site-directed manner. Alternativ ely, selection pressure may be applied in an arbitrary or exploratory manner, e.g., by changing the buffer conditions, temperature, timing or protocol oi the selection process. A defined sequence segment with binding specificity mimicking that ot an antibody tor its antigen is identified using a selection method relying on competiti e dissociation ol the antigen-antibody complex (i.e.. a ligand-receptor dissociation method), as descnbed below for a monoclonal IgG antibody against the chemokine, human ιnterleukιn-8 (IL-8). IL-8, also known as monocyte-denved neutrophil chemotactic factor, is a member of the chemokine alpha or C-X-C family. The mature torm of human IL-8 consists of 72 amino acids, has a molecular weight of about 8,000 daltons and, like other chemokines, has four cysteine residues. IL-8 is a chemotactic factor that exhibits activ ity in vitro toward T cells, neutrophils and basophils, as measured, e.g., by the enzymes myeloperoxidase, α- mannosidase and β-glucuromdase. Recombinant IL-8 is expressed in E. coli, punfied (>97% puπty by SDS-PAGE), diluted in PBS-BSA, stenle filtered and lypohihzed. Muπne monoclonal antibody specific tor IL-8 (antι-IL-8) was produced from mice immunized with recombinant IL-8 and shown to neutralize the biological activ ity of recombinant IL-8 (Sigma Chemical Company. St. Louis MO). The IgG fraction of the ascites fluid was punfied by protein A affinity chromatography. Specificity for IL-8 was demonstrated by indirect ELISA and western blot assays using a crossreactivity panel including, e.g., recombinant human RANTES, recombinant human GRO-α. recombinant human MlP-α, recombinant human MlP-β, recombinant mouse MIB-l-α and recombinant mouse MIB-l-β. When immobilized on a microtiter plate, the antibody is capable of captunng recombinant as well as natural IL- 8. Proteins (e.g., IL-8 or antι-IL-8 antibody) are immobilized at room temperature to either paramagnetic particles or 96-well polystyrene microtiter plates according to the following protocols. In each case, control solid phases without immobilized antigen or antibody are prepared in parallel for use as counterselection matnces (e.g., to select against nucleic acids that bind supports and/or support-bound blocking agents such as BSA). For paramagnetic particles (amine-modified BIOMAG: Advanced Magnetics, Cambπdge MA ) is washed fiv e times with v igorous v ortexing and magnetic separation in 10 mM sodium phosphate (NaPi; pH 7.4) at a particle concentration of 5- 10 mg/ml. After the final wash, the et cake is resuspended to 25 mg/ml in 6.25% glutaraldehyde (GA; Sigma Chemical Company . St. Louis MO) and rotated at room temperature tor three hours. GA- treated particles are washed six times in NaPi. Washed. GA-activated particles are resuspended w ith PBS (pH 7.2-7.4) containing the protein to be immobilized at a final concentration oi 3-10 mg/ml. An aliquot of the protein solution is retained for determination of immobilization efficiency. The protein-particle slurry is rotated at room temperature for 16-24 hours. Particles are magnetically separated. The supernatant is decanted and retained for estimation of residual protein. Unreacted GA groups are quenched by resuspension of particles to about 10 mg/ml in 1 M glycine (pH 8.0) followed by rotation for one hour. Quenched particles are washed twice in PBS (pH 7 4) and blocked by rotation tor two to four hours in PBS containing 2 mg/ml BSA. Blocked particles are washed three times in PBS containing 1 mg/ml BSA. resuspended to a particle concentration of 10 mg/ml and stored at 2-8 °C Working aliquots are washed three times in assay butter w ith thorough v ortexing at a particle concentration of about 1 mg/ml prior to use to protect against artiiacts from leaching oi immobilized reagents with prolonged storage. Alternativ ely . IL-8 or antι-IL-8 antibody is noncovalently adsorbed to surface- modified polystyrene microtiter plates by passive adsoφtion according to the following protocol. Proteins are diluted to 2-20 ug/ml in 50 mM carbonate buffer (pH 9.6) or 10 mM sodium phosphate (pH 7.4) in borosihcate glass tubes or 50 ml polypropylene centnfuge tubes immediately before use. Clear polystyrene IMMULON™ 4 or hite MICROLITE™ 2 flat-bottomed microtiter plates (Dynatech Coφoration, Chantilly VA) are coated at 100 μl per well for 2 hours at 37 °C, 4 hours at room temperature (20-23 °C) or 15-24 hours at 2-8 °C. Plates are decanted and washed once by filling wells with wash buffer (PBS (pH 7.4) containing BSA at 1 mg/ml) and decanting. Wells are blocked for 1 hour w ith 200 μl PBS containing 2 mg ml BSA and washed five additional times with wash buffer. In modifications of this coating procedure, plates are pretreated or post-treated with 0.2-2.5% GA followed by quenching (i.e., with an excess of amines, e.g., using 1 M lysine) and reduction (e.g.. using sodium cyanoborohydnde) to covalently attach antibodies, particularly tor selection methods relying on harsh selection pressures and/or thermal cycling. IL-8 is specifically bound to washed BIOMAG-antι-IL-8 particle preparations by gently rotating a mixture of antigen (2-10 ug/ml) and particles ( 1 -3 mg/ml) for tvvo hours at room temperature. Immobilized antibody -antigen complexes (BIOMAG-antιbody-IL-8) are washed tive times at a particle concentration oi 300 ug/ml and resuspended to a particle concentration of 5 mg/ml. The specifically bound IL-8 solid phase is stored at 2-8 °C and w ashed three times immediately beiore use. A div erse mixture compnsing approximately 10 13 single-stranded RNA molecules consisting of a 30-nucleotide randomized sequence flanked by PCR pnmer-annealing sequences is prepared by methods known in the art (e.g., Ellington and Szostak (1990) Nature 3-^6:818-822). Nonspecific, solid phase-binding nucleic acids are remov ed from the mixture by preabsorption w ith f reshly w ashed BIOMAG-antι-IL-8 and control BIOMAG (200 μl each). Two hundred microliters of freshly washed BIOMAG-antιbody-IL-8 is then added to the counterselected nucleic acid mixture. The nucleic acid-plus-BIOMAG reaction mixture is incubated with gentle rotation for 10 minutes at room temperature and magnetically separated. The resulting supernatant (compnsing unbound nucleic acids and nucleic acιd-IL-8 complexes formed by dissociation of IL-8 trom the antι-IL-8 solid phase) is transieπed to a clean 12x75 mm test tube, leaving behind the separated solid phase (compnsing immobilized antibody-antigen complexes, immobilized complexes with nucleic acids bound noncompetitiveh to antibody-bound IL-8, and immobilized antibody lacking bound IL-8 (due to nucleic acid-dependent competitiv e dissociation)). The supernatant comprises free nucleic acids, free IL-8 (dissociated from solid phase immune complexes either spontaneous!} and/or b} immobilized antibod} -binding RNA molecules) and nucleic acιd-IL-8 complexes tormed by competitive displacement of IL-8 irom immobilized antibod} . Nucleic acιd-IL-8 complexes are separated irom the supernatant mixture by gel chromatograph} using a SEPHADEX G-25 column (crosshnked dextran; Pharmacia LKB. Piscatawa} , NJ). Nucleic acids comprising separated complexes are then amplified b} PCR under thermal c} cling conditions that dissociate bound IL-8 Charactenzation of each IL-8-bιndιng RNA sequence is preferabh accomplished b} 1 ) sequencing the IL-8-bιndιng RNA molecule, 2) prepanng a synthetic heteropolymer that includes a first defined sequence segment compnsing the IL-8-bmdιng sequence and a second defined sequence segment selected to hybndize an HRP-ohgonucleotide conjugate (cf. Example 8) separated by nucleotide spacers, and 3) determining percent binding, affinity and specificity of PCR-amplified selected nucleic acids for IL-8 by modified ELISA using IL-8-coated microtiter plates as solid support and HRP-ohgonucleotide conjugate as reporter. Synthetic heteropolymers are first titrated in a PBS-TWEEN™ -BSA assay buffer against plates coated with 500 ng/well of recombinant IL-8. Plates are decanted and washed once in assay buffer. The HRP-ohgonucleotide conjugate is then hybridized to bound synthetic heteropolymers, plates are decanted and washed tw ice in assay buffer, and HRP is developed by addition of a liquid substrate system compnsing 3.3',5,5'- tetramethylbenzidine (TMB; Sigma Chemical Company, St. Louis MO). Color development is determined either tanetically at 655 nm (blue) or by iirst stopping reactions with 0.5 M sulfuric acid and reading the endpoint at 450 nm (yellow ). The specificity of selected RNA sequences ior IL-8 is determined by competition assay at half-maximally effectiv e synthetic heteropohmer concentrations (i.e.. EC50) using a crossreactiv ity panel compnsing recombinant mouse and human interleukins (i.e., interleukins 1 through 15) and selected recombinant interleukin receptors. Defined sequence segments shown to specifically bind IL-8 in competition assays using interleukins and interleukin receptors as competing crossreactants are subsequently ev aluated in competition assay s w ith reierence antibody (i.e.. the parent antι-IL-8 antibody) and optionally by structure probing. In a first set ot expenments. the ability of synthetic heteropolymers and conesponding RNAs (e.g., f irst def ined sequences) to inhibit the binding ol antι-IL-8 antibcxiv to IL-8-coated plates is tested in ELISA format using a goat anti-mouse IgG-HRP conjugate as labeled second antibody . Selected RNA sequences that potently inhibit antι-IL-8 binding (i.e., as determined by both RNA and conesponding synthetic heteropolymer inhibition) are then evaluated in a reciprocal assay system, i.e., using antι-IL-8 antibody as a competitive inhibitor of synthetic heteropolymer binding to IL- 8-coated plates. HRP-ohgonucleotide conjugate is used as secondary label. Synthetic heteropoly mers shown to be mutually competitiv e with parent antι-IL-8 antibody in reciprocal ELISA configurations (i.e., RNA sequence inhibits antibody binding and antibody inhibits synthetic heteropolymer binding) are selected as IL-8 antibcxiv mimics. To iurther resolv e the specificity of a selected defined sequence as compared with parent antibcxiv . epitope mapping may be achieved by structure probing or by modified ELISA using a synthetic heteropolymer assay protocol. A panel oi monoclonal (mouse anti- human) anti-mierleukin Fab fragments hav ing specificities against human IL- 1 through IL- 15 is used to identify competitiv e inhibitors ot synthetic heteropolymer binding to IL-8- coated plates. HRP conjugated to affinity purified, light chain-specific goat anti-mouse antibody (OEM Concepts, Toms Riv er NJ) is used as labeled secondary antibody. Defined sequence segments mimicking the specificity of ligands (e.g., interleukins) for their receptors (e.g., soluble, cloned interleukin receptors) can also be selected by ligand-receptor dissociation methods like those described in the preceding paragraphs tor selecting antibody mimics. In this case, howev er, the ligand (e.g., recombinant human ιnterleutan-4: IL-4) rather than an antibody or receptor is immobilized (e.g., on paramagnetic particles). IL-4 receptor (e.g., recombinant soluble receptor fragment) is specifically bound to immobilized IL-4 to form an IL-4 mimic-displaceable immobilized receptor-hgand complex. When incubated with a suitably counterselected (i.e., using control solid phases) library of nucleic acids, e.g., an RNA or transcnbed cDNA library with randomized nucleotides flanked by primer annealing sequences, binding of IL-4 mimetic nucleic acids to solid phase-IL-4-bound IL-4 receptor lragments results in dissociation of IL-4 receptors into the supernatant in the form of nucleic acιd-IL-4 receptor complexes. Nucleic acιd-IL-4 receptor complexes are punfied by gel chromatography. Nucleic acids of punfied complexes are dissociated and amplified by PCR, sequenced and charactenzed by ELISA methods substantially as descnbed in the preceding paragraphs. Competition assay s are performed using interleukins. interleukin receptors and antι-IL-4 receptor antibodies to determine the specificity oi selected nucleic acid IL-4 mimetics compared with the parent ligand. Detined sequence segments (i.e., aptamers) that mimic the binding specificity of low molecular eight drugs can also be selected by receptor dissociation methods disclosed herein, as can aptamers that mimic drug receptors. For example, H2 receptor-mimetic aptamers (i.e.. synthetic histamine receptors) are selected using a cimetidine solid phase prepared, e.g., by immobilizing αmetidine-BSA conjugate to GA-activated BIOMAG particles and specifically binding cloned histamine H2 receptors A nucleic acid library is counterselected against BIOMAG and BIOMAG-BSA. BIOMAG-H2 receptor and a mixture comprising cloned H2 receptor and BSA in PBS. Nucleic acids remaining following counterselection are selected against the BIOMAG-BSA -cιmetιdιne-H2 receptor solid phase for sequences capable of binding cimetidine by competitiv ely displacing specifically bound H 2 receptors. Bound nucleic acids are separated by magnetic separation and washing, amplified by PCR and sequenced. Binding of selected defined sequence segments (e.g., specificity and affimty ot defined sequence segments compnsing bitunctional synthetic heteropolymers) is compared with the parent drug, cimetidine, by competiti e assay using HRP-ohgonucleotide conjugate tor detection in cimetidme-BSA -coated microtiter plates with and w ithout v ary ing dilutions of histamine agonists and antagonists. Mimetic deiined sequence segments selected to mimic the binding specificity oi ligands and receptors (e.g., drugs, hormones, receptors, antibodies and antigens) as illustrated in the instant example are advantageously incoφorated into synthetic heteropolymers and aptamenc and heteropolymenc multimolecular dev ices of the invention. IL-8 antibody mimetics and IL-4 and cimetidine ligand mimetics. tor example, may be used as defined sequence segments compnsing aptamenc and heteropolymenc multimolecular sensors, particularly for drug discovery and more particularly high-throughput screening assays. Alternativ ely , mimetic sequences may be used as targeting or drug-binding defined sequence segments compnsing multimolecular drug delivery systems. Example 14: Selection of aptamers using single-molecule detection and sequencing of target-bound nucleic acids Single-molecule sequencing techmques currently under dev elopment enable the sequence of bases in talobase fragments of DNA to be determined at rates up to several bases per second. Modifications of these techmques can be used to detect and sequence nucleic acid molecules (e.g., from synthetic oligonucleotide hbranes) capable oi binding nonoligonucleotide target molecules, e.g., following library selection for target-binding nucleic acids. Direct detection and identification ot specifically bound nucleic acids without amplification is accomplished using modifications of single-molecule DNA sequencing methods (e.g., Jett J.H. et al. (1992) In: Human Genome 1991-92 Program Report, DOE/ER-0544P. pp. 129-130; Harding et al. (1992) Trends in Biotechnology 10:55-57). Nucleic acids capable of binding a selected target molecule are identified by incubation of the target molecule with a diverse mixture of nucleic acids, preierably a nucleic acid library, and separation oi target-bound nucleic acids. For relatively large targets (e.g., soluble proteins, membrane receptors, cell surface antigens, membrane fragments, particles or cells), separation is achiev ed, e.g., by size exclusion, centπfugation, membrane or gel filtration or filter binding. For low molecular weight targets ( e.g.. haptens or small drug molecules, hormones, dyes or fluorophores), separation is preierably achiev ed by solid phase absorption using a hgand-modified membrane, bead, microparticle or affinity support. Diverse mixtures oi nucleic acid hbranes are preferably prepared by automated synthesis of nucleic acids compnsing at least one randomized region, preierably compnsing about 20 to 50 randomized nucleotides. Nucleotide-identifymg fluorescent tags (i.e., selected fluorophores that uniquely identify each type of nucleotide in the sequence) are advantageously used to facilitate laser-induced fluorescence detection of individual nucleotides for single-molecule sequencing. A selected nonoligonucleotide target (e.g., an omega-3 -unsaturated iatty acid, a pesticide, enzyme, coenzyme, redox mediator, bacterial hpopolysacchande. iral envelope protein or lectin) is incubated with a mixture of nucleic acids, preierably a diverse nucleic acid library . Bound nucleic acid-target complexes are separated trom the remainder of the mixture, e.g.. by gel filtration or affinity chromatography . Punfied complexes are optionally dissociated by heating and rechromatographcd to isolate target-binding nucleic acids Alternatively , sequencing is performed using target-bound nucleic acids by selecting exonucleases capable of cleav ing nucleotides without pnor dissociation. In a first method for identifying aptamenc sequences, laser-induced fluorescence is used to identify and sequence fluorescenth' tagged, target-bound nucleic acid molecules. Aptamer-target complexes are suspended at 37 °C in the flow stream ot a flow cytometer capable of single-fluorophore detection. Tagged nucleotides are cleaved sequentially from bound nucleic acid molecules by exonuclease (e.g., E. coli exonuclease III) and identified by laser-induced fluorescence as they pass through the excitation laser beam. Alternatively, single-molecule sequencing may be achieved using laser-induced detection of endogenous nucleotide fluorescence, i.e., without using fluorophore- tagged nucleotides for nucleic acid library preparation. Target-bound sequences are isolated in an optical trap, and nucleotides are successively cleaved using exonuclease. Cleaved nucleotides are separated from the parent nucleic acid and irradiated by a laser to excite their nativ e fluorescence. The identity oi cleaved nucleotides is determined by spectral analysis and companson with the stored spectra of each nucleotide used for library synthesis (e.g., A, G. U and C for an RNA library) Sequences determined by single-molecule sequencing oi target-bound nucleic acids are used to program an automated DNA synthesizer tor production of synthetic heteropohmers (or optionally aptamers) compnsing selected defined sequence segments. Synthetic heteropolymers are produced at sufficient scale (e.g., typically about ten nanomoles) to enable determination of affinity (e.g., binding constant by Scatchard analysis) and specificity (e g , percent binding to selected target v ersus potential crossreactants) by modified ELISA methods (cf Example 13, vide supra) Ty pically , synthetic heteropolymers prepared for binding studies compnse a first defined sequence segment identified by single- molecule sequencing as a target-binding sequence and a second defined sequence segment capable of hy bndizing an HRP-ohgonucleotide conjugate, optionally separated by nucleotide spacers Alternatively, second defined sequence segments are selected to hybndize a biotinvlated or digoxigenin- modified ohgonucleotide, enabling detection with a selected streptav ldin-effector conjugate (e.g., streptavidin conjugated to R-PE, AP, GO, or a fluorescent microsphere) or effector-labeled anti-digoxigemn antibodies For charactenzing aptamers selected for the ability to bind effector molecules (e.g., R-PE), synthetic heteropolymers are preferably prepared with a first defined sequence segment compnsmg the selected effector-binding sequence (e.g., R-PE-binding aptamer) and a second defined sequence segment conjugated to a conesponding donor or acceptor molecule (e.g., APC) Charactenzation can then be achiev ed by homogeneous assay , wherein binding ot target effector to the selected (i.e . iirst) deiined sequence segment results in functional coupling ith APC conjugated to the second defined sequence segment. Example 15: 4ptamer selection by single-molecule transfer of target-bound nucleic acid Recent advances in proximal probe techniques, particularly , scanning probe microscopes (SPM) and more particularly scanning tunneling microscopes (STM) and atomic force microscopes (AFM) provide the ability to image molecules and groups of molecules with unprecedented resolution (e.g., nanometer and ev en subnanometer detail). It is now possible to perform biomechanical studies on indiv idual proteins, to physically manipulate indiv idual protein and DNA molecules and to detect interactions between macromolecules. Prototype instruments now provide the capability of acquiπng nanometer- scale SPM images simultaneously with relatively large-field optical microscopy images (e.g., by bπght-field or trans-illumination or epi-fluorescence). It is therefore possible to first scan an entire field or slide in search of a particular site, structure, image or signal (e.g.. with micron-scale resolution) and then zoom in with an SPM probe to intenogate the image at far greater resolution (e.g., nanometer-scale). On demonstrating molecular-resolution images of immunoglobulins and hpids by AFM Hansma et al. ( Clinical Chemistry 37: 1497-1501 ( 1991a)) suggested that a dedicated AFM could be used as a versatile, albeit expensive, biosensor by scanning a surface having an affinity for a particular type of molecule until detecting an indiv ldual molecule of this type. High-throughput sequencing of DNA has also been proposed (e.g., Hansma et al. ( 1991b) J. Vac. Sci. Techn. B 9: 1282- 1284), potentially at rates several orders of magnitude faster than conventional sequencing techniques. Imaging of single-stranded DNA and antigen-antibody complexes has been reported (e.g., Weisenhorn et al. ( 1990) Scan. Microsc. 4:51 1-516). AFM has also been used to determine and/or measure, e.g., DNA length, moφhology and degree ot coiling (including changes in length w ith drug binding), protein binding to DNA and protein-induced DNA bending, effects of ionic strength on the supercoihng structure of double- stranded DNA, and the pitch of the DNA helix in fluid. AFM can be used to directly map specific sites on plasmid and cosmid DNA molecules, e.g., by v isualizing DNA restnction sites labeled with mutant restnction enzymes. Reproducible imaging and even dissection of plasmid DNA has also been reported (e.g., Henderson ( 1992) Nucleic Acids Research 20:445-447, Hansma et al. ( 1992) Science 256: 1180-1184). It is therefore apparent that SPM, particularly AFM, can be used to study the interaction of drugs and DNA-binding proteins with DNA, ligands with receptors (e.g., antigen-antibody binding), and can even be used to dissect and extract biological DNA (e.g. , from plasmids and supercoiled DNA). Disclosed in this example are novel methods relying on SPM. preferably AFM, to isolate and sequence individual synthetic nucleic acids selected for the ability to bind indiv idual identified targets, optionally including an amplification step to enable sequencing by routine methods ( i.e., automated, capillary or gel-based methods rather than single- molecule sequencing as described in Example 14, vide supra). The instant methods are not directed, as is the pnor art, tow ard determining or imaging the interaction of DNA-binding proteins w ith naturally occurnng nucleic acids (i.e., DNA or RNA). Nor are the instant methods directed toward measunng the binding and/or effect oi a drug on biological DNA or RNA. Nor does the present invention provide methods to screen or select heretofore unknow n drugs or hbranes for the ability to interact with DNA or RNA. Rather, and contrary to pnor art teachings, methods disclosed in this example are specifically directed toward the identification of individual synthetic nucleic acids capable oi specifically binding selected nonoligonucleotide molecules, particularly ligands, receptors, structural molecules and effector molecules, having no heretofore known affimty for naturally occurnng RNA or DNA. In addition, the instant methods enable the charactenzation and selection of an identified target- binding nucleic acid (i.e., an aptamer) based upon the binding force as measured by SPM. preterably AFM, of the aptamer-target interaction. In addition, methods are provided for removing an individual, selected aptamer from its bound target (i.e., dissociating the aptamer-target complex) and transporting the aptamer to a sequencing apparatus or amplification vessel. The selected aptamer is then amplified or sequenced, preferably first amplified and then sequenced, enabling synthesis of the deiined sequence segment (e.g., at nanomolar scale) for routine charactenzation of binding affimty and specificity (e.g., by modified ELISA). Provided aptamer binding to the selected target molecule is found to be specific (i.e., the aptamer speciiicalh binds the selected target), the selected aptamer sequence is produced by large-scale synthesis, preterably as a defined sequence segment compnsing a synthetic heteropolymer and or an aptamenc multimolecular device. Among the many possible SPM conf igurations that can be applied to aptamer selection using SPM for smgle-molecule detection, four particularly pretened protocols are descnbed herein. In each protocol. AFM is used as the proximal probe technique of choice, though it will be apparent to one ot skill in the art that STM and/or hybnd probe techmques can also be used. The four prefened protocols represent the four possible combinations of tvvo basic reagent architectures and two different sequenαng subroutines. The two reagent architectures are 1 ) target immobilized on substrate (i.e.. AFM slide), and 2) target immobilized on AFM tip. The t o sequencing paths are a) smgle-molecule sequencing (e.g., by fluorescence) without prior amplification, and b) single-molecule amplification followed by conventional sequencing. The four basic protocols are therefore: la) single- molecule AFM detection of aptamer bound to substrate-immobilized target followed by single-molecule sequencing, lb) single-molecule AFM detection of aptamer bound to substrate-immobilized target followed by single-molecule amplification and conv entional sequencing, 2a) smgle-molecule AFM detection of aptamer bound to AFM up-immobilized target followed by single-molecule sequencing, and 2b) single-molecule AFM detection of aptamer bound to AFM tip-immobilized target follo ed by smgle-molecule amplification and conv entional sequencing. Binding of a synthetic nucleic acid (i.e., a selected aptamer) to an AFM substrate- immobilized target molecule is detected as follow s. The identified target molecule, human thyrocalcitomn (Sigma Chemical Company, St. Louis MO), is dissolved in Tns buffer (pH 7.4) at a concentration of 25-250 ug/ml and spotted onto a freshly cleav ed mica surface. After a 5-50 minute incubation, the surface is nnsed thoroughly with buffer, dried under nitrogen and probed with a NANOSCOPE® II AFM (Digital Instruments. Santa Barbara CA) by raster-scanning a shaφ silicon nitnde probe attached to a 100 x 20 x 1.0 micron cantilever over the sample surface in accordance with the manufacturer's recommendations. This instrument has a maximum scan range of approximately 10 x 10 microns. Image resolution (i.e.. lines per image and points per line) vanes with scan speed and image size. Images obtained by scanning 500 x 500 nm demonstrate thyrocalcitomn molecule densities in the range of 10-100 molecules per square micron, depending on the coating concentration and time. Following imaging, the substrate is πnsed in buffer and dned under nitrogen. A mixtore of nucleic acid molecules compnsing a 50-nucleotιde randomized region flanked by PCR pnmer-annealing sequences is incubated with slivers of freshly cleaved mica to remove substrate-binding nucleic acids. A twenty microhter aliquot of clanfied supernatant oi the mica-counterselected solution is spotted onto the πnsed, thyrocalcitonin-modified substrate. After a 10-mιnute incubation, the substrate is nnsed. dned under nitrogen, and scanned again using the NANOSCOPE® SPM. After identification of a nucleic acid-thyxocalcitonin complex (as determined by increased topological height compared w ith immobilized thyrocalcitomn scans), the scan is stopped and the tip-substrate feedback turned off. A loading iorce is then titrated from about the nanonewton (nN) to the micronewton (μN) range, depending on the apparent binding force of the nucleic acid-thy rocalcitonm complex. To extract the bound nucleic acid molecule (i.e., the anti-thyrocalcitonm aptamer with flanking pnmer-annealing sequences), one line scan is performed at a loading force determined to dislodge the bound nucleic acid molecule. The probe tip with attached nucleic acid molecule is then retracted from the substrate-target surface and transfened to a microtuge tube containing PCR pnmers and enzymes in 10 μl oi amplification buffer. The extracted thyrocalcitomn-binding nucleic acid molecule is then amplified and sequenced. The propensity of the AFM probe tip (which has a slightly negativ e surface charge in water) to adsorb nucleic acid molecules dunng scanning and extraction phases may be altered by modify ing the probe tip with coupling agents having positively or negatively charged functional groups. Since the probe tip (e.g., silicon nitnde). nucleic acid and mica substrate are all ty pically negatively charged, nonspecific binding is not a significant problem. Optimal adhesiv e forces between the probe tip and sample nucleic acid molecule may be achiev ed through use of divalent cations, cationic pids and/or nonaqueous probing solutions. The mica surface may also be modified, e.g., by deposition and ev aporation ot neutral or near-neutral coatings and/or hydrophobic or h}drophιlιc groups. Alternativ eh . modified-nucleotide and/or backbone-modified nucleic acid hbranes compnsing neutral or near-neutral nucleic acids ma} be used to maximize specific aptamer-target binding and minimize nonspecific adhesiv e forces among the sample, probe tip and mica substrate. To ensure more permanent attachment of the selected target (to either the AFM substrate or probe tip), e.g., to select a high affinity nucleic acid-target complex requinng a large loading force ior probe-induced dissociation, the target is covalently immobilized. For example, pπmary amines can be thiolated in a borate buffer (pH 8.0) using Traut's reagent (2-ιmιnothιolane-HCl: Pierce Chemical Company, Rockford IL). After desalting, the thiol - modified target is covalently bonded to a substrate compnsing gold freshly evaporated on mica, optionally using a nebulizer to spray the target onto the substrate. Alternative substrates and immobilization protocols for achiev ing relatively homogeneous distnbution, stable attachment and desired coverage (i.e., surface density ) of different types of molecules are known in the art. For single-molecule detection and single-molecule sequencing, the protocol is modified as iollow s The sample library compnses nucleic acids prepared w ith fluorescenth tagged nucleotides compnsing a 50-nucleotide randomized sequence and a 50-nucleotιde fixed region (to iacihtate imaging) Thyrocalcitomn immobilization, nucleic acid binding, AFM scanning and nucleic acid extraction are performed as in the preceding paragraph, but the selected and dislodged nucleic acid is transiened w ith the probe tip to a microtuge tube containing 10 l oi sequencing buffer and unloaded by rev ersing polanty oi the tip The sequencing butter containing the fluorescenth tagged, isolated nucleic acid is then aspirated to the flow cell of a cy tometer capable ot single-fluorophore detection, and the nucleic acid is suspended at 37 °C m the flow stream Tagged nucleotides are cleaved sequentially by exonuclease and identified by laser-induced fluorescence as they pass through the excitation laser beam For nucleic acid selection protocols rely ing on AFM probe-immobilized target, thyrocalcitomn is attached to the silicon nitnde probe tip by passiv e adsoφtion in 10 mM sodium phosphate buffer (pH 7 4) Alternativ ely , the probe surface is first modified with a silane coupling agent (e.g , 4-amιnobuty ldιmethylmethoxy sιlane, United Chemical Technologies, Bnstol PA) Thyrocalcitomn is then cov alently attached using a homobiiunctional crosshnker (e g., glutaraldehyde) or heterobitunctional crosshnker (e.g., SULFO-SMCC or EDC, Pierce Chemical) or, optionally, site-directed attachment v ia the amine terminus (e.g , by mild peπodate oxidation) or the carboxyl terminus (e g , by rev erse proteolysis in the presence of the dihydrazide ot carbonic acid to produce a C- terminal hydrazo group) Mica-counterselected nucleic acid libranes are prepared and applied to treshly cleav ed mica substrate as described in the preceding paragraphs. Scanning of the sample is performed in a feedback mode until binding of nucleic acid to the tip-immobilized thvrotropin is detected The probe tip is then retracted from the substrate-target surface, and the bound nucleic acid molecule is transiened either to a microtuge tube containing PCR pnmers and enzymes (l e , for amplification and sequencing) or. in the case of fluorescenth tagged nucleic acid, to a microfuge containing sequencing buffer d e , tor smgle-molecule sequencing) Alternativ ely , thyrocalαtonin-modified tip-bound nucleic acids may be transiened. ior single-molecule sequencing, directly to the flow cell ot a sequencing cytometer apparatus To maximize imaging sensitiv ity tor target-bound nucleic acids and to enhance discnmination between target-bound nucleic acids and uncomplexed immobilized targets, nucleic acids may be labeled with a detectable molecule (e.g., a protein or other macromolecule), preferably a signal-generating species (e g , an enzyme, fluorophore, polymer, dye, colloid, nanoparticle or microparticle). Labeling may be accomplished dunng nucleic acid preparation, e.g., by using labeled or modified nucleotides during nucleic acid synthesis or by post-synthetic conjugation or modification oi the nucleic acid. Alternatively, nucleic acids may be labeled alter they are applied to the SPM substrate, e.g , using a secondary label ( i.e., labeled binding partner) or dye such as an ohgonucleotide-enzyme, ohgonuclcotide-gold or ohgonucleotide-fluor conjugate, an ohgonucleotide immobilized to a nanosphere or microsphere, a labeled anti-nucleic acid antibody or streptav ldin conjugate, an intercalating dye or nucleic acid-bmding substance. These labeling techmques can also be used to maximize library screening efficiency. Target-bound nucleic acids can be detected by low resolution scanning of large imaging fields (e.g., 1- 10 square microns). High resolution scanning can then be used to extract bound nucleic acids trom complexes located at coordinates identified in gross scans. Alternatively , conventional optical microscopy can be used for low resolution detection of labeled nucleic acid-target complexes, e.g., using bπght-field, epi- fluorescent or contocal techniques. Having determined the position oi a target-bound nucleic acid by v isualizing an attached label (e.g., a latex or colloidal gold particle, dye or fluorophore) or a localized signal generated by an attached label (e.g., an insoluble colored or fluorescent product of a reporter enzyme), the operator can then zoom to high resolution w ith the SPM probe ior scanning and extraction ot the bound nucleic acid. In a particularly prei erred embodiment of single-molecule aptamer selection, a selected target compnses or is labeled with a iirst etfector molecule, preferably a signal- generating species, optionally an enzyme or luminescent compound, more preferably a first fluorescent nanoparticle or microparticle having a first selected size, color or absoφtion or emission spectrum or property, hereafter refened to as a first fluorescent nanoparticle having a first spectral property. A mixture of nucleic acids is prepared or selected, preferably by automated chemical synthesis or by enzymatic synthesis, amplification or transcπption of a library compnsing nucleic acids having a randomized sequence and at least one fixed nucleotide or nucleotide sequence for conjugation, optionally compnsing one or more f ixed sequences lor pnmer annealing and amplification. The nucleic acid mixture, preierably a random-sequence library and hereafter refened to as such, is counterselected against selection butter compnsing selected effector molecules, preterably (iirst and second) fluorescent nanoparticles or dyed microparticles. Nucleic acids compnsing the random- sequence library are conjugated at a molar ratio of about 0.1-3.0 (molecules/ particle), more preterably about 0.3-1.0 (molecules/particle), to a second effector molecule, preferably a signal-generating species, optionally an enzyme or luminescent compound, more preferably a second fluorescent nanoparticle or microparticle having a second selected size, color or absoφtion or emission spectrum or property using a modified fixed-sequence nucleotide or tixed nucleotide. preferably a 3' or 5' terminal amino, thiol or carboxyl group, more preierably a 5' aminohnker-modiiied nucleotide. The selected target, which is either itself an effector molecule (e.g., an enzyme, fluorophore, nanoparticle or dye polymer) or is conjugated to an effector molecule, hereafter presumed to be conjugated to a second fluorescent nanoparticle having a second spectral property , is incubated with the first fluorescent nanoparticle-conjugated. counterselected random-sequence library in selection buffer. Selection buffer conditions, particle conjugation and bloctang conditions and first and second particle ratios are preselected to obviate nonspecific nanoparticle-nanoparticle interactions, and complete monodispersion ot nanoparticles is ensured by somcation immediately before aptamer selection. Optionalh , the selection incubation is doped with unconjugated nanoparticles having a third and advantageously w hite, black, opaque, transparent, e translucent spectral property to control against nonspecific or spunous interaction between first and second fluorescent nanoparticles. Indiv idual aptamer-attached complexes compnsing first and second fluorescent nanoparticles are selected by single- molecule detection, isolation and/or amplification methods know n in the art. particularly using fluorescence microscopy and more particularly single-cell flow cytometry (e.g., Lewin et al. ( 1992) Genomics 73:44-48; Li et al. ( 1991 ) Methods: Comp. Meth. Enzymol. 2:49-59; Mirsky et al. ( 1993) PCR Meth. Appl. 2:333-340: Patterson et al. ( 1993) Science 260:976-979). A laser-based flow cytometer equipped w ith a single-cell deposition device, tor example, is used to sort fluorescent nanoparticles and isolate aptamer-attached doublet nanoparticle complexes, preierably doublet complexes compnsing iunctionally coupled donor and acceptor fluorescent nanoparticles, by multicolor fluorescence, adv antageously fluorescence energy transier ot functionally coupled nanoparticle complexes. Huorescent nanoparticles conjugated to nonsense ohgonucleotide and to blocking protein (e.g., casein) are used as internal standards (e.g., for calibration and gating) and negativ e controls. Biotinvlated casein-conjugated fluorescent donor nanoparticles (i.e., first nanoparticles) and streptav idin-conjugated acceptor nanoparticles (i.e., second nanoparticles) are used as positiv e controls f or doublet nanoparticle complex formation and detection. To validate the selection procedure, positiv e controls are doped with negativ e controls at ratios ranging from 10- 16 to 10 1 Alternati ely , methods descnbed in the preceding paragraph are modified tor detection, isolation, amplification and/or sequencing using a combination of optical microscopy , optical trapping and or SPM methods. Detection by SPM. for instance, is preferably achieved using targets and nucleic acids conjugated to particles diffenng in size, color and/or fluorescence. In a prefened embodiment, the ef ficiency of nucleic acid library selection is enhanced by screening multiple targets or target anants conjugated to different selected effector molecules, preferably a family oi signal-generation species expressing vaπations in a selected type of detectable signal (e.g., size, color, photon absoφtion or emission, enzyme activity ), advantageously nanoparticles and/or microparticles varying in either size or color or fluorescent properties. In a particularly pref ened embodiment, efficiency is further enhanced by screening multiple targets, each distinctly labeled by a first family of signal-generating species (e.g., nanoparticles and microparticles of v arying size) against multiple libranes of varying design, preferably a spectrum of diverse libranes representing diffenng regions of chemical and sequence space, advantageously a diverse library of chemically diverse random-sequence nucleic acid hbranes, w herein the libranes compnse random-sequence nucleic acids having fixed- sequence nucleotides or fixed- position nucleotides conjugated to a second and optionally a third or fourth or N 1 * 1 different iamilv oi signal-generation species expressing vanations in a ditferent ty pe of detectable signal, preferably nanoparticles and microparticles v arying, e.g., in color or fluorescence. SPM imaging of binding events with molecular scale resolution is a potentially useful tool for high-throughput screening of diverse mixtures ot compounds, e.g., combinatonal libranes. SPM provides a method of detecting a single binding event between a prospectiv e ligand or receptor and a selected target, enabling efficient library construction and screening. Once detected, a target-bound ligand or receptor can be physically isolated trom all other members of the library or mixture. But tor lack of a method to charactenze, preierably identity , a single detected molecule (i.e., to determine its chemical composition and structure), molecular detection and isolation by SPM would enable screening and selection of molecular libranes, e.g., combinatonal libranes. w ith unprecedented resolution and ef ficiency . Ho ever, because a general method does not yet exist to precisely and accurately charactenze mdiv ldual selected molecules (i.e.. to determine the chemical identity ot a selected molecule), the potential of SPM for selecting and characterizing compounds from chemical libranes has not been realized. Methods of the instant example enable not only the detection ot selected members compnsing div erse mixtures of compounds, e.g., combinatonal libranes, but also structoral charactenzation (i.e., sequencing) and functional analysis (e.g., detailed binding studies following large-scale synthesis) of selected nucleic acids. Unlike nonnucleotide molecules, a single nucleic acid molecule selected from a mixture by SPM can be amplified and sequenced to determine its chemical identity. Also, because its possible to sequence single nucleic acid molecules, e.g., using laser-induced fluorescence of tagged nucleotides (cf. Example 14. vide supra), hy bnd SPM-sequencing techniques can be used to screen, select and charactenze molecules compnsing nucleic acid libraries on a single-molecule scale. In other words, the combination of single-molecule detection (e.g.. using AFM) and single- molecule sequencing (e.g., using laser-induced fluorescence of dye-tagged nucleotides) provides a nov el approach to detection, isolation and charactenzation of individual molecules from mixtures compnsing synthetic nucleic acids, e.g., nucleic acid libraries and particularly highly diverse libranes of nucleic acids. This single-molecule selection and identification capability relies on single-molecule sequencing and/or single-molecule amplification of nucleic acids and therefore cannot be applied to libranes oi nonnucleotide molecules (i.e., unless compound-specific nucleotide codes are generated dunng synthesis or nonnucleotides are conjugated to compound-specific ohgonucleotide tags). Methods descnbed herein for identifying and sequenαng defined sequence segments compnsing aptamers can also be applied, with modification, to the selection and sequencing of defined sequence segments compnsing nucleotide ligands and nucleotide receptors, e.g., by screening and selection of nucleotide-encoded chemical libranes and/or nucleotide-encoded libranes compnsing modified nucleotides or nucleotide analogs. SPM- based nucleic acid selection and sequencing methods descnbed herein therefore enable the detection, selection, and identification, optionally including amplification, of useful ligands and receptors from diverse mixtures of nucleotides, particularly libranes of nucleic acids compnsing randomized sequences (i.e., for aptamer selection), libranes of nucleic acids compnsing modified nucleotides or nucleotide analogs (i.e.. for selection of nucleotide ligands or nucleotide receptors), or libranes of molecules whose synthesis, composition or structure is coded by an associated nucleotide sequence (i.e.. nucleotide-encoded chemical branes). The interaction of nucleotide ligands, nucleotide receptors and aptamers with selected target molecules may further be charactenzed by well known structure probing methods following amplification oi deiined sequence segments compnsing the selected nucleotides. Example 16: Aptamer selection by molecular proximity Light microscopy (e.g., coniocal, fluorescent and bnght-iield). flow cytometry (e.g., fluorescence activated sorting), proximal probe techmques (e.g., AFM, STM, SFM, SECM) and/or optical trapping and manipulation (e.g., laser scanning, force fields and optical tweezers) can be used to discπminate two macromolecules. conjugates or particles attached by a nucleic acid from corresponding uncomplexed macromolecules, conjugates or particles. In a simple case, a first macromolecule or particle is conjugated to fixed sequences (or nucleotides) of nucleic acids compnsing a randomized sequence library. SPM is then used to detect paired molecules resulting from a randomized sequence (i.e., aptamer) binding to a macromolecular target molecule or a target-macromolecule conjugate. For example, human serum albumin is conjugated to the amino-modified 5' termini of 36mer RNAs compnsmg a library hav ing 30-nucleotide randomized sequences. The library is then incubated w ith the target molecule HRP. The HRP-albumm complex is detected topographically by AFM, followed by amphiication and or sequencing of the complex- torming aptamer by methods descnbed elsewhere herein (ci. Example 15, vide supra). Offline amplification is accomplished by loading force-mediated aptamer extraction and transfer to a microfuge tube compnsing pnmer(s) and enzymes in amplification buffer. On-site amplification is performed using in situ hybndization (e.g., Patterson et al. (1993) Science 260:976-979), optionally using degenerate ohgonucleotide pnmers and/or pnmer extension. Thermal cycling (e.g., using PCR or LCR) or isothermal amplification (e.g., 3SR or CPR) may be used. Alternatively, the selected aptamer may be sequenced in situ by SPM (provided adequate resolution can be achieved) or. preferably, transferred to a single- molecule sequencing apparatus (e.g., a laser-dπven nucleotide fluorescence detector). Aptamers or synthetic heteropolymers compnsing the selected sequence are then produced by large-scale enzvmatic or chemical synthesis (e.g., using PCR or and automated DNA synthesizer). Improv ed detection can be achieved using a uniform nanoparticle (e.g., 20 nm latex or colloidal gold) in place oi albumin to amplify the topographical signal. In this case, the target molecule is preierably also conjugated so that nucleic acid and target species are of similar size (i.e., tor maximal discπmination of paired v s. unpaired molecules). Buffer and blocking conditions are optimized to obviate nonspecific particle and protein interactions. Counterselection is performed using the conjugated molecule(s) and/or partιcle(s) and buffer. In a v anation of this molecular proximity selection method, a selected aptamer assembles two molecules or particles by hybndizing to one and specifically binding the other. The target is conjugated, e.g., to ferntin (i.e., a high molecular weight protein or polymer; alternativ es include punfied KLH or dextran) The nucleic acid library is synthesized w ith a fixed sequence capable of hybndizing to an oligonucleotide conjugated to a 20 nm uniiorm nanosphere. Nanosphere-binding and ferntin-binding nucleic acids are remov ed by counterselection. Library -target binding is performed in solution, and nanosphere-conjugated ohgonucleotide is added pnor to AFM imaging. Nanosphere - conjugated ohgonucleotide hybndization to fixed sequences yields nucleic acid-hybndized nanospheres and nanosphere-aptamer-HRP-ferntin complexes. The nanosphere-aptamer- HRP-fe tin complex is discπminated topographically from nucleic acid-hybndized nanospheres and femtin-HRP conjugates by AFM, and aptamers are isolated and sequenced as per Example 15 (vide supra). Using selected molecules as reporters for single-molecule detection, proximity- based methods can be used to select and isolate one or more aptamers based upon user- defined selection cnteπa or thresholds. For example, by v arying the size, density and/or surface charge of the reporters conjugated to target molecules and nucleic acids compnsing a random-sequence library, an attinity threshold or set point can be established to select an indiv idual aptamer or group of aptamers with desired binding strength. The aptamer binding strength required to assemble two nanospheres (i.e., target-nanosphere and aptamer- nanosphere conjugates) and remain bound throughout selection, detection and isolation steps increases exponentially with particle diameter. Affinity set points spanning more than four orders of magnitude can be established using as reporters uniform latex nanospheres having particle diameters ranging from 10-300 nm. To select an aptamer with high affinity for the enzyme AP, a large-scale library is prepared compnsing 90mer RNA molecules having 30-nucleotide iixed hybndization sequences and 60-nucleotιde randomized sequences. The 30-nucleotide fixed sequence is complementary to a 30mer ohgonucleotide immobilized to each oi three batches of fluorescent red carboxylate-modified polystyrene nanospheres varying in particle diameter (20 nm, 50 nm and 100 nm). AP is conjugated to a first 32mer ohgonucleotide complementary to a second 32mer ohgonucleotide that is immobilized to each of three different batches (i.e., 20 nm, 50 nm and 100 nm particle diameter) of fluorescent green carboxylate-modified polystyrene nanospheres using a water-soluble carbodiimide. Nanospheres are thoroughly sonicated immediately beiore use and suriace charge, immobilization protocol, blocking, concentration, and butfer conditions are optimized to obviate nonspecific particle-particle interactions, as determined by coniocal fluorescence microscopy . The random-sequence library is counterselected against the different nanospheres and immobilized ohgonucleotide preparations, and the mixture compnsing sumving RNA molecules is incubated with the AP-ohgonucleotide conjugate. Aliquots oi the AP-ohgonucleotide plus RNA mixture are pipetted into mne reaction essels, and a complementary set ot capture nanospheres is added to each essel in a checkerboard design (i.e., one red RNA-reporter plus one green AP-reporter particle set per v essel, 3x3=9 particle diameter combinations). Confocal fluorescence microscopy is used to identify red- green particle complexes AFM is used for proximity -based detection and isolation of aptamer-AP-attached particle complexes Irom each v essel Indiv idual tight-binding, aptamer- hnked complexes are selected as those remaining intact w ith AFM extraction under probe - induced loading torces in the 10 ~8 - 10° new ton range. To explore div erse nucleic acid libranes for higher affinity aptamers, randomized sequence lengths can be increased to 100, 150 or 200 nucleotides, optionally ev en more than 200 nucleotides. preterably by hgating two or more nucleic acids comprising less than about 100 nucleotides each A parallel expenmental design is applied at fixed particle size (20 nm red and green fluorescent nanospheres, as per the preceding paragraph) using carboxylate modified latex particles of varying surface charge and partang area. The repulsiv e torce of negative surface charge on paired particle sets (i.e.. red plus green fluorescent sets) is titrated against a random -sequence RNA library to select for indiv idual aptamers with high AP- ohgonucleotide binding strength. The influence of particle density is inv estigated using submicron diameter glass beads, silamzed iron oxide particles and stabilized liposomal v esicles w ith poly sty rene nanospheres as reference. Alternativ e aptamer selection parameters include the macromolecular size, weight and density of selected molecules used as signal -generating species ior single-molecule detection (e.g., v ia STM, AFM, laser scanmng and optical trapping) These properties can be detected optically , topographically , or by changes in loading or discharge force accompanying association, dissociation or extraction of a selected target or target-aptamer complex by SPM or optical trapping methods, e.g., AFM or SPEC. In a preiened mode of operation, molecular proximity is used as a selection cntenon detectable by the tunctional coupling (e.g., enzyme channeling, fluorescence energy transfer) resulting from aptamer- mduced assembh of first and second selected molecules compnsing a donor-acceptor pair. Alternativ e embodiments of aptamer selection b} molecular proximity rely on different methods tor co alent, pseudoineversible or specific binding ot a iirst selected molecule, conjugate or particle to a first fixed sequence or nucleotide ot nucleic acids compnsing a random-sequence library. Binding ot the second, randomized sequence to a second selected molecule (i.e., the selected target, optionally a conjugated selected target) results in assembh of a complex compnsing at least three molecules (i.e.. first and second selected molecules attached by the selected aptamer). Covalent attachment is preferably- directed to a fixed 3' or 5' nucleotide and/or spacer sequence, preferably an amino-modified nucleotide, using a heterobifunctional crosshnker (e.g., SMCC, MBS. SPDP or the corresponding water-soluble sulfo-crosshnker). Specific binding of a first selected molecule to first fixed sequence or nucleotide may be accomplished, e.g., using an existing aptamenc defined sequence segment specific for the first selected molecule, optionally a conjugate compnsing the selected molecule. Alternatively , anti-digoxigenin/digoxigemn. nucleotide ligands or nucleotide receptors may be used. Pseudoinev ersible binding may be achieved using av ldin-biotm, streptav ldin-biotin or hybndization oi an ohgonucleotide conjugate. It w ill be apparent on reading the instant disclosure that an aptamenc nucleic acid selected and charactenzed by molecular proximity of attached selected molecules compnses a synthetic heteropolymer. That is, the selected and identified aptamer compnses a first deiined sequence segment capable oi specifically binding a iirst selected molecule and a second defined sequence segment capable of specifically binding, hybπdizing or co alently positioning a second selected molecule for detection. Methods descnbed in the instant example therefore exploit the useful molecular positiomng properties of synthetic heteropolymers as a selection cπtenon for detection, isolation and identification of individual aptamers. Example 17: Aptamer selection by single-molecule detection of functional coupling between donor and acceptor pairs assembled by random-sequence nucleotides The detectabihty of two attached selected molecules, preferably tw o effector molecules, more preferably two signal-generating molecules and optionally two Iunctionally coupled signal-generating species, prov ides a useful tool for selecting defined sequence segments, nucleotide ligands and nucleotide receptors for the ability to specifically recognize one or both of the selected molecules. MOLECULAR MACHINES ot the instant invention can perform useful work that depends on nucleotide-dependent molecular positioning ot selected molecules, particularly ligands, receptors and effector molecules. Nucleotide-dependent molecular positioning provides a general approach for attaching two or more selected molecules to a nucleotide scaffold or template. In prefened aspects of the invention, nucleotide-dependent molecular positioning results in functional coupling between two selected molecules to generate an output which depends on the proximity of the selected molecules. For example, in a multimolecular transducer compnsing the donor and acceptor fluorophores R-PE and R-PC bound to neighboπng defined sequence segments of a synthetic heteropolymer. energy is transferred from donor (R-PE) to acceptor (R-PC) on excitation with an argon-ion laser. Alternatively , a highly diverse mixture of nucleic acids (e.g., a library compnsing 10 13 to 10 15 60mer RNA molecules) can be selected for indiv idual RNA molecules capable of binding both a donor and an acceptor fluorophore using fluorescence microscopy with suitable excitation and emission filter sets. The practicality of selecting for a single RNA molecule capable of binding both donor and acceptor fluorophores is limited, however, by two constraints. First, the bound fluorophores must produce a sufficiently intense signal to enable detection of a single donor-acceptor pair. Huorescent nanospheres and supramolecular light hanesting structores are useful in this regard. Second, the diversity of an RNA library must be sufficiently diverse to express at least one RNA molecule capable of binding both the donor and the acceptor fluorophore. If only one RNA molecule in 10 10 has a useful affinity for a selected target molecule (i.e., a target compnsing or attached to a donor fluorophore), then only about one m 10 20 RNA molecules (i.e., 10 ~10 x 10 ~10 molecules) is likely to bind both of two selected molecules (e.g., a donor and acceptor fluorophore) required lor detection by functional coupling (i.e., fluorescence energy transfer) An RNA library comprising even 10 15 or 10 16 members is therefore highly unlikely to contain even a single member capable of binding both the donor and the acceptor fluoiophore. Methods descnbed herein address both the detectabihty and diversity challenges that must be ov ercome to select an individual nucleic acid molecule for its ability to connect tvvo signal-generating species, thus rendenng them detectable. Single-molecule detectabihty is achiev ed by either using at least tvvo highly intense signal-generating species as selected targets, by conjugating at least one selected target to a highly detectable signal-generating species or, more preferabh , conjugating approximately each member of a div erse nucleic acid mixture to a highly detectable signal-generating species either cov alently , by high- af finity specific binding (e.g., using streptav idin/biotin or anti-digoxigenin/digoxigenin) or by pseudoineversible attachment (e.g., hybndization ot an ohgonucleotide/signal-generating species conjugate) Diversity is addressed by attaching a first signal-generating species to approximately each member of the diverse nucleic acid mixture, e.g., by synthesizing each member of the mixture with a fixed modified nucleotide or defined sequence segment known to specifically bind the first signal-generating species (or a conjugate compnsing the first signal -generating species) or by covalenth attaching, specifically binding or pseudoinev ersibly attaching (e.g., hybndizing) the first signal-generating species to approximately each member of the nucleic acid mixture. Attachment may be achieved, e.g., using a covalent crosshnking reagent, anti-digoxigenin/digoxigenin, streptavidin/biotin, or a hybndizable ohgonucleotide-effector conjugate. In this way, the probability of identifying a member of the nucleic acid mixtore capable of connecting the two signal-generating molecules is increased to approximately the likelihood of identifying a single RNA molecule capable of binding a single target molecule. Screening and selection of a library compnsing member nucleotides conjugated to a first (donor or acceptor) signal-generating species tor binding to a second (donor or acceptor) signal-generating species is preferably accomplished by single-molecule detection, charactenzation, sequencing and/or amplification as descnbed elsewhere herein (e.g., Example 16, vide supra). Pπor to conjugation of random-sequence nucleotides compnsing the library to a iirst (donor or acceptor) signal-generating species, the library is preselected or counterselected against the signal-generating species to remov e unwanted random- sequence nucleic acids. As an example of library selection by iunctional coupling between a conjugated donor and an aptamer-bound acceptor, random- sequence nucleotides are biotinvlated and labeled with an HTC-streptavidin conjugate. R-PE-bound HTC-streptav idin-conjugated aptamers are then selected, optionally following column chromatography . by single- molecule detection of tightly coupled complexes, i c , complexes having intense R-PE fluorescence (I e.. at about 575 nm) and lacking the charactenstic fluorescem emission ( I .e., at 515-520 nm). As will be apparent to the skilled artisan on reading the instant example, donor or acceptor signal-generating species (i.e., oxidoreductases, fluorophores, luminescent compounds) can be conjugated to fixed nucleotides or fixed sequences of nucleotides compnsing a diverse library by attachment methods know n in the art, e.g., hybndization of an ohgonucleotide-effector conjugate, covalent conjugation using heterobifunctional crosshnkers, specific binding of labeled ligands or receptors (e.g., labeled anti-digoxigenin or av idin), incorporation of tagged nucleotides dunng nucleotide synthesis, chelation to metals compnsing modified nucleotides. intercalation oi dyes and/or fluorophores within duplex regions of partially or fully double-stranded nucleotides, enzymatic labeling, and the like For purposes ot clarity oi understanding, the f oregoing inv ention has been descnbed in some detail by way ot illustration and example m conjunction with specific embodiments, although other aspects, advantages, modes ol operation and modifications will be apparent to those stalled in the art to which the invention pertains The ioregoing descnption and examples are intended to illustrate, but not limit, the scope oi the inv ention. Modifications oi the above-descnbed modes ior carrying out the inv ention that are apparent to persons of skill in nucleic acid chemistry , molecular biology , biomedical research, vetennan , agncultural and environmental sciences, clinical medicine, diagnostics, pharmaceuticals, drug delivery , combinatonal chemistry , informatics, nanotechnology, matenals science, semiconductors, micromachming, optics, electronics, immunology, climcal chemistry , electrochemistry , enzymology, fluorescence, luminescence, sensors, transducers, actuators, microelectromechamcal systems, nanoelectromechanical systems, instrumentation and related fields are intended to be within the scope of the invention, which is limited only by the appended claims All publications and patent applications cited in this specification are indicative of the level oi stall of those stalled in the art to which this inv ention pertains and are herein incoφorated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reierence.

Claims: What is Claimed is: 1. A sy nthetic heteropolymer compnsing: a first synthetic defined sequence segment capable of specifically recognizing and covalently attaching a first selected nonoligonucleotide molecule; and a second defined sequence segment attached to the first synthetic defined sequence segment with the proviso that the second defined sequence segment is not a fixed, unconjugated pnmer-annealing sequence. 2. The sy nthetic heteropolymer of claim 1 herein the first synthetic defined sequence segment is attached to the second defined sequence segment v ia a nucleotide spacer. 3. The sy nthetic heteropolymer ot claim 1 w herein the first synthetic defined sequence segment is attached to the second defined sequence segment v ιa a nonnucleotide linker. 4. The sy nthetic heteropolymer of claim 1 w herein the first selected nonoligonucleotide molecule compnses a specific binding partner oi the first synthetic defined sequence segment. 5. The synthetic heteropolymer erf claim 1 w herein the first selected nonoligonucleotide molecule compnses a specifically attractiv e surface feature. 6. The sy nthetic heteropolymer ot claim 1 w herein the second defined sequence segment is capable ot specificalh recognizing a second selected nonoligonucleotide molecule or a selected nucleic acid sequence. 7. The synthetic heteropolymer of claim 6 wherein the second selected nonoligonucleotide molecule compnses a specific binding partner of the second defined sequence segment. 8. The synthetic heteropolymer of claim 6 wherein the second selected nonoligonucleotide molecule compnses a specifically attractiv e surface feature. 9. The synthetic heteropolymer of claim 1 wherein the second defined sequence segment is capable of hybndizing to a selected nucleic acid sequence. 10. The synthetic heteropolymer of claim 1 wherein the second defined sequence segment is a conjugated defined sequence segment. 1 1. A multimolecular transducer compnsing the synthetic heteropolymer of claim 1 . 12. A multimolecular switch compnsing the sy nthetic heteropolymer of claim 1. 13. A multimolecular sensor compnsing the sy nthetic heteropolymer of claim 1. 14 A multimolecular delivery system compnsing the synthetic heteropolymer of claim 1. 15. A multivalent multimolecular structure compnsing a multiv alent impnnt of the sy nthetic heteropoh mer of claim 1. 16. The multivalent multimolecular structure ot claim 15 wherein the multivalent impnnt is an idiotypic mimetic. 17. The multivalent multimolecular structore of claim 15 wherein the multivalent impnnt is an antiidiotypic impnnt. 18. A heteropolymenc discrete structure compnsing a synthetic aptamer and a defined sequence segment attached to the synthetic aptamer w ith the prov iso that the defined sequence segment is not a fixed, unconjugated pnmer-annealing sequence or a nbozyme. 19 The heteropolymenc discrete structure ot claim 18 w herein the defined sequence segment compnses an aptamer, a nucleotide sequence which specifically binds or hybπdizes to a selected nucleic acid sequence, or a conjugated defined sequence segment. 20. The heteropolymenc discrete structore of claim 18 wherein the synthetic aptamer compnses a shape-specific recognition element. 21. The heteropolymenc discrete structore of claim 18 wherein the defined sequence segment is attached to the synthetic aptamer via a nucleotide spacer. 22. The heteropolymenc discrete structore of claim 18 wherein the defined sequence segment is attached to the synthetic aptamer v la a nonnucleotide linker. 23. A multimolecular transducer compnsing the heteropolymenc discrete structure of claim 18. 24. A multimolecular switch compnsing the heteropolymenc discrete structure of claim 18. 25. A multimolecular sensor compnsing the heteropol menc discrete structure of claim 18 26. A multimolecular delivery system compnsing the heteropolymenc discrete structure of claim 18 27 A multiv alent multimolecular structure compnsmg a multiv alent impnnt of the heteropolymenc discrete structure oi claim 18. 28. The multivalent multimolecular structure ot claim 27 wherein the multivalent impnnt is an ldioty pic mimetic. 29. The multivalent multimolecular structure of claim 27 w herein the multivalent impnnt is an antiidiotypic impnnt. 30. A molecular adsorbent compnsing a solid phase and a multivalent template compnsing a first specific recognition element specifically attached v ia the first specific recogmtion element to the solid phase wherein the solid phase compnses an amphibious or specifically attractiv e surface. 3 1 The molecular adsorbent of claim 30 wherein the multiv alent template iurther compnses at least a second speciiic recognition element capable oi speciiically recognizing a selected nonoligonucleotide molecule. 32. The molecular adsorbent of claim 30 wherein the multiv alent template further compnses at least a second speciiic recognition element capable oi specifically hybndizing a selected nucleic acid sequence. 33. A multimolecular adherent compnsing a specific recognition element and a first selected molecule attached to the specific recogmtion element wherein the specific recognition element specifically attaches via specific binding or shape-specific recogmtion the first selected molecule to a second selected molecule ol an amphibious or specifically attractiv e surface 34. The multimolecular adherent of claim 33 wherein the second selected molecule compnses a specific binding partner of the specific recogmtion element. 35. The multimolecular adherent of claim 33 herein the second selected molecule compnses a specifically attractive surface feature. 36. A multimolecular adhesive compnsing at least two specific recognition elements capable of specifically attaching and joining at least two surfaces wherein at least one of the specific recognition elements specifically recognizes an amphibious or specifically attractive surface. 37. The multimolecular adhesive of claim 36 w herein at least one of the specific recognition elements specifically binds to a selected molecule of an amphibious surface. 38. The multimolecular adhesive of claim 36 wherein at least one of the specific recogmtion elements specifically recognizes a surface feature of a speciiically attractive surface. 39. The multimolecular adhesive of claim 36 wherein at least one of the specific recogmtion elements hybπdizes to a nucleic acid sequence immobilized to the amphibious or specifically attractiv e surface. 40. A multivalent heteropolymenc hybnd structore compnsing a first synthetic heteropolymer hybndizably linked to a second synthetic heteropolymer w herein each synthetic heteropolymer compnses at least tvvo defined sequence segments and at least one deiined sequence segment of the first synthetic heteropolymer specifically recognizes a selected nonoligonucleotide molecule. 41. The multivalent heteropolymenc hybnd structure of claim 40 wherein the selected nonoligonucleotide molecule compnses a specific binding partner of the at least one defined sequence segment of the first synthetic heteropolymer. 42. The multivalent heteropolymenc hybnd structore of claim 40 wherein the selected nonoligonucleotide molecule compnses a specifically attractive surface feature specifically recognized by the at least one defined sequence segment of the first synthetic heteropolymer. 43. The multivalent heteropolymenc hybnd structure of claim 40 herein at least one defined sequence segment ot the second synthetic heteropolymer specifically recogmzes a second selected nonoligonucleotide molecule. 44. The multivalent heteropolymenc hybnd structure of claim 43 wherein the second selected nonoligonucleotide molecule compnses a specific binding partner of the at least one defined sequence segment of the second synthetic heteropolymer. 45. The multivalent heteropolymenc hybnd structure of claim 43 w herein the second selected nonoligonucleotide molecule compnses a specifically attractive surface feature specifically recognized by the at least one defined sequence segment of the second synthetic heteropol mer. 46. The multivalent heteropolymenc hybnd structure oi claim 40 w herein at least one defined sequence segment of the second synthetic heteropolymer speciiically binds a selected nucleic acid sequence. 47. The multivalent heteropolymenc hybnd structure oi claim 40 wherein the at least tvvo defined sequence segments of the second synthetic heteropolymer hybndize to selected nucleic acid sequences. 48. The multivalent heteropolymenc hybnd structure of claim 40 wherein at least one defined sequence segment of the second synthetic heteropolymer comprises a conjugated defined sequence segment. 49. A multimolecular transducer compnsing the multivalent heteropolymenc hybnd structure of claim 40. 50. A multimolecular switch comprising the multiv alent heteropolymenc hybnd structore of claim 40. 51. A multimolecular sensor compnsing the multiv alent heteropolymenc hybnd structure of claim 40. 52. A multimolecular delivery system compnsing the multivalent heteropolymenc hybnd structure of claim 40. 53. A multiv alent multimolecular structure compnsing a multivalent impnnt of the multivalent heteropolymenc hybnd structure of claim 40. 54. The multivalent multimolecular structure of claim 53 wherein the multivalent impnnt is an idiotypic mimetic. 55. The multivalent multimolecular structore of claim 53 wherein the multivalent impnnt is an antiidiotypic impnnt. 56. An aptamenc multimolecular device compnsing a nonaptamenc specific recogmtion pair and a synthetic aptamer which specifically binds or shape-specifically recognizes an aptamer target wherein a member oi the nonaptamenc specific recogmtion pair is conjugated to the aptamer to form a conjugated aptamer 57 The aptamenc multimolecular device of claim 56 wherein the conjugated aptamer is capable oi positiomng the aptamer target ior iunctional coupling with a member oi the nonaptamenc specific recognition pair. 58. The aptamenc multimolecular device of claim 56 wherein the conjugated aptamer or the aptamer target further compnses an effector molecule. 59. The aptamenc multimolecular device of claim 56 wherein the nonaptamenc specific recognition pair compnses a nucleotide ligand or nucleotide receptor. 60. The aptamenc multimolecular device of claim 56 wherein the aptamer target compnses a surface ieature of a specifically attractiv e surface. 61. A multimolecular transducer comprising the aptamenc multimolecular dev ice oi claim 56. 62. A multimolecular switch compnsing the aptamenc multimolecular device of claim 56. 63. A multimolecular sensor compnsing the aptamenc multimolecular device of claim 56. 64. A multimolecular delivery system compnsing the aptameric multimolecular dev ice of claim 56. 65. A multivalent multimolecular structure compnsmg a multivalent impnnt of the aptamenc multimolecular device of claim 56. 66. The multivalent multimolecular structure ot claim 65 wherein the multivalent impnnt is an idiotypic mimetic. 67. The multivalent multimolecular structore of claim 65 wherein the multivalent impnnt is an antiidiotypic impnnt. 68. A tethered specific recogmtion device compnsing a molecular scaffold and at least tw o members of a specific binding pair or shape-specific recognition pair wherein the members of the specific binding pair or shape-specific recogmtion pair are covalently or pseudoinev ersibly attached to the molecular scaffold. 69. The tethered specific recognition device of claim 68 wherein the at least tvvo members of the specific binding pair or shape-specific recogmtion pair are specifically and directly attached to each other. 70. The tethered specific recogmtion device of claim 68 w herein at least one member of the specific binding pair or shape-specific recognition pair compnses an effector molecule. 71. The tethered specific recogmtion device of claim 68 wherein the molecular scaffold compnses a nonnucleotide molecule. 72. The tethered specific recogmtion device of claim 68 wherein the molecular scaffold compnses a replicatable nucleotide, 73. The tethered specific recognition device ot claim 68 wherein at least one member of the specific binding pair or shape-specific recogmtion pair compnses an aptamer. 74. A tethered specific recogmtion device compnsing a molecular scaffold and at least four members of at least two specific recogmtion pairs wherein each member is covalently or pseudoineversibly attached to the molecular scaffold. 75. The tethered specific recognition device of claim 74 wherein at least one of the two specific recognition pairs compnses a specific binding pair. 76. The tethered specific recognition device of claim 74 wherein at least one of the two specific recognition pairs compnses a shape-specific recogmtion pair. 77. The tethered specific recognition device of claim 74 wherein at least one of the two specific recognition pairs compnses hybndizable selected nucleic acid sequences. 78. The tethered speciiic recogmtion device oi claim 74 w herein specific attachment of the tvvo members of one specific recognition pair precludes specific attachment of the two members of another specific recogmtion pair. 79. A paired specific recogmtion device compnsing a nucleotide-based molecular scaffold and at least two different specific recognition pairs conjugated to the molecular scaffold wherein at least one specific recognition pair is capable ot specific binding or shape- specific recognition. 80. The paired specific recogmtion device ot claim 79 wherein the molecular scaffold is capable oi positiomng the at least two specific recogmtion pairs for functional coupling between at least tvvo members of the at least tvvo specific recognition pairs. 81. The paired specific recogmtion device of claim 79 wherein at least one member of one of the at least two specific recogmtion pairs compnses an effector molecule. 82. The paired specific recogmtion device of claim 79 wherein the molecular scaffold further compnses a nonnucleotide molecule. 83. The paired specific recognition device of claim 79 wherein the molecular scaffold compnses a replicatable nucleotide. 84. The paired specific recognition device of claim 79 wherein at least one member of the at least two specific recognition pairs compnses an aptamer. 85. The paired speciiic recogmtion device of claim 79 wherein at least one member of the t o speciiic recogmtion pairs is specifically and directly attached to its specific recognition partner. 86. A multimolecular transducer compnsing the paired specific recogmtion device of claim 79. 87. A multimolecular switch compnsing the paired speciiic recognition device of claim 79 88. A multimolecular sensor compnsing the paired specific recognition dev ice of claim 79. 89. A multimolecular delivery system compnsing the paired specific recogmtion device of claim 79. 90. A multivalent multimolecular structure compnsing a multivalent impnnt of the paired specific recogmtion device of claim 79. 91. The multivalent multimolecular structure of claim 90 wherein the multivalent impnnt is an idiotypic mimetic. 92. The multivalent multimolecular structure of claim 90 wherein the multivalent impnnt is an antiidiotypic impnnt. 93. A nonaptamenc multimolecular device compnsing a conjugated defined sequence segment and at least two different specific binding pairs or shape-specific recognition pairs w herein one member of each specific binding pair or shape-specific recognition pair is conjugated to the conjugated defined sequence segment. 94. The nonaptamenc multimolecular device of claim 93 wherein the conjugated defined sequence segment is capable of positioning the specific binding pairs or shape- specific recognition pairs for functional coupling between at least tvvo members of the specific binding pairs or shape-specific recognition pairs. 95. The nonaptamenc multimolecular device of claim 93 wherein the conjugated member of at least one of the specific binding pairs or shape-specific recognition pairs compnses a modified nucleotide. 96. The nonaptamenc multimolecular device of claim 93 wherein the conjugated member of at least one of the specific binding pairs or shape-specific recognition pairs compnses a nucleotide ligand or nucleotide receptor. 97. A multimolecular transducer compnsing the nonaptamenc multimolecular dev ice of claim 93 98. A multimolecular switch compnsing the nonaptamenc multimolecular device of claim 93. 99. A multimolecular sensor compnsing the nonaptamenc multimolecular device of claim 93. 100. A multimolecular delivery system compnsing the nonaptamenc multimolecular device of claim 93. 101. A multivalent multimolecular structure compnsing a multivalent impnnt of the nonaptamenc multimolecular device of claim 93. 102. The multivalent multimolecular structure ot claim 101 wherein the multivalent impnnt is an idiotypic mimetic. 103. The multivalent multimolecular structore ot claim 101 wherein the multivalent impnnt is an antiidiotypic impnnt. 104. A shape-specific probe compnsing a nucleotide-based or nonnucleotide recognition element capable of recognizing a specifically attractiv e surface feature. 105. The shape-specific probe of claim 104 wherein the recognition element compnses an aptamer. 106. The shape-specific probe of claim 104 wherein the recognition element compnses a nucleotide ligand or nucleotide receptor. 107. The shape-specific probe of claim 104 w herein the recognition element compnses a selectable nonoligonucleotide molecule. 108. A multimolecular structure compnsing the shape-specific probe of claim 104. 109. A multiv alent impnnt of a multimolecular structure compnsing at least two specific recognition elements impnnted from the multimolecular structure. 110. The multiv alent impnnt of claim 109 w herein the impnnted specific recognition elements from the multimolecular structure mimic the at least two specific recogmtion elements of the multimolecular structure. 1 11. The multivalent impnnt of claim 109 w herein the impnnted specific recogmtion elements from the multimolecular structore are capable of specifically recogmzing the at least two specific recognition elements of the multimolecular structure. 112. A paired nucleotide-nonnucleotide mapping library compnsing a plurality of selected specific recogmtion partners capable of transposing a selected population of selected nonoligonucleotide molecules into replicatable nucleotide sequences. 1 13. A method for selecting a single synthetic nucleotide molecule capable of recogmzing a labeled or unlabeled selected target molecule compnsing detecting a signal resulting from the proximity or functional coupling between the single synthetic nucleotide and the selected target molecule. 1 14. The method of claim 113 wherein the single synthetic nucleotide is selected from a nucleotide library. 1 15. The method of claim 113 wherein the single synthetic nucleotide molecule compnses a molecule selected from the group consisting of an aptamer, a nbozyme, a catalytic nucleotide, a catalytic DNA molecule, a nucleotide catalyst, a nucleotide ligand and a nucleotide receptor. 116. The method of claim 113 wherein the single synthetic nucleotide molecule compnses an aptamer that specifically recogmzes the selected target molecule and is capable of forming a single discrete structure compnsing the aptamer and the selected target molecule. 1 17. The method oi claim 113 wherein the single synthetic nucleotide molecule comprises an aptamer-effector conjugate that specifically recognizes the selected target molecule and is capable of forming a single discrete structure compnsing the aptamer- effector conjugate and the selected target molecule. 118. The method of claim 116 wherein the selected target molecule compnses an effector molecule. 119. The method of claim 113 wherein the single synthetic nucleotide molecule compnses a catalytic nucleotide that recogmzes a catalytic recognition partner compnsing the selected target molecule. 120. The method of claim 113 wherein the single synthetic nucleotide molecule compnses a shape-specific probe that specifically recognizes a surface feature of a specifically attractiv e surface. 121. The method of claim 113 wherein the signal is detected v ia optical microscopy, flow cytometry or detection oi a photon emitted by a signal-generating species. 122. The method of claim 113 wherein the signal is detected by single-molecule detection v ιa scanning probe microscopy . 123. The method of claim 113 further compnsing amplifying the single synthetic nucleotide molecule or determining the nucleotide sequence ot the single synthetic nucleotide molecule. 124 A method for identifying a specifically attractiv e surface feature compnsing: (a) contacting a surface library with a selected shape-speciiic recognition partner; and (b) detecting attachment ot the selected shape-specific recogmtion partner to a speciiically attractiv e surface ieature of the surface library 125. The method oi claim 124 wherein the shape-speciiic recognition partner is detectabh labeled. 126. The method of claim 124 wherein attachment is detected by single-molecule detection. 127. The method of claim 126 wherein smgle-molecule detection is performed by scanning probe microscop . 128 An immobilized multimolecular structure compnsing a solid support and a multimolecular structure immobilized to the solid support wherein the multimolecular structore is selected from the group consisting of aptamenc multimolecular devices, heteropolymenc discrete structores, multivalent heteropolymenc hybnd structures, synthetic heteropolymers, tethered specific recognition devices, paired specific recognition devices, nonaptamenc multimolecular devices, multivalent molecular structures, multivalent impnnts, and multimolecular drug delivery systems. 129. A multimolecular drug delivery system compnsing a multimolecular structure selected from a group consisting of aptamenc multimolecular devices, heteropolymenc discrete structures, multivalent heteropolymenc hybnd structures, synthetic heteropolymers, tethered specific recogmtion devices, paired speciiic recognition devices, nonaptamenc multimolecular dev ices, multivalent impnnts, and immobilized multimolecular delivery systems wherein the multimolecular structure contains a synthetic receptor that specifically recogmzes a drug or a selected target.

Inventors: CUBICCIOTTI ROGER S, CUBICCIOTTI, ROGER, S.
Applicants: MOLECULAR MACHINES INC, MOLECULAR MACHINES, INC.
Application year: 1999
Main classification: C12Q1
IPC codes: C07H21