USE OF WATER-SOLUBLE/DISPERSIBLE REACTIVE DERIVATIVES OF POLYIMIDO COMPOUNDS FOR MODIFYING PROTEINACEOUS SUBSTRATES

Abstract: This invention relates to water-soluble/dispersible reactive imido and polyimido compounds, wherein the polyimido compounds may be selected from the group consisting of polysuccinimide compounds, polyglutimide compounds, and copolymers thereof. The polyimido compounds comprise a water-solubilizing/dispersing moiety that provides water-solubility and/or water-dispersibility to the polyimido compound and preferably is derived from a nucleophilic moiety selected from the group consisting of amines, alcohols, phenols, thiols, and carboxylates. The present invention also pertains to a proteinaceous substrate to which the imido or polyimido compound has been covalently bonded and to a method for treating a proteinaceous substrate with the imido or polyimido compound.

Description: Use of Water-soluble/dispersible Reactive Derivatives of Polyimido Compounds For Modifying Proteinaceous Substrates Field of the Invention This invention relates to water-soluble/dispersible reactive imido and polyimido compounds, wherein the polyimido compounds may be selected from the group consisting of polysuccinimide compounds, polyglutimide compounds, and copolymers of thereof. The polyimido compounds comprise a water-solubilizing/dispersing moiety that provides water-solubility and/or water-dispersibility to the polyimido compound and preferably is derived from a nucleophilic moiety selected from the group consisting of amines, alcohols, phenols, thiols, and carboxylates. The present invention also pertains to a proteinaceous substrate to which the imido or polyimido compound has been covalently bonded and to a method for treating a proteinaceous substrate with the imido or polyimido compound. Background of the Invention Hair is a proteinaceous substrate containing protein chains connected by sulfur-sulfur cross-linkages from cystine. When hair is bleached or permed, the cystine disulfide bonds are cleaved, typically with sodium thioglycolate, sodium sulfite, or some other disulfide bond-cleaving agent. The hair is then put into a curled or straightened state, whichever is desired, and the disulfide bonds are then allowed to reform. New sulfur-sulfur cross-linkages between the protein chains are formed thus locking the hair into the new array. In practice, not all of the disulfide bonds reform. This cleavage of the sulfur- sulfur cross-linkages results in a weakening of the hair making it more susceptible to breakage during combing and brushing. In addition, because perming formulations are generally very alkaline, some amide linkages in the protein chains are also cleaved resulting in a further weakening of the hair. Currently, there is no cosmetically acceptable method of improving strength by imparting additional cross-linkages to hair. Moreover, both the strength of the hair and the combing properties of the hair are adversely affected by the perming/bleaching process. Conventional treatments to improve the combing properties include various conditioning agents. However, because these conditioning agents do not covalently bond to hair, their conditioning effects are removed by washing and must be repeatedly applied. Improved shine and gloss, UV protection, anti-stat properties, anti-microbial protection, color, as well as many other improvements, which are desirable to intact and/or damaged hair, all suffer from a lack of permanence on hair and must be continually replenished. While there are many disclosures that describe compositions useful for modifying proteinaceous substrates, none of the disclosures describe compositions that are entirely satisfactory. None of the disclosures describe the preparation of water-soluble or water-dispersible reactive polyimido compounds that can be covalently and permanently bonded to a proteinaceous substrate. The present invention provides such improved water-soluble or water-dispersible polyimido compounds, many of which, upon reaction, revert to biodegradable and environmentally friendly compounds. SUMMARY OF THE INVENTION This invention relates to a polyimido compound selected from the group consisting of polysuccinimide compounds represented by Formula (1): - L (1) polyglutimide compounds represented by Formula (2); n 2 (2) and copolymers of the polysuccinimide compounds represented by Formula (1 ) with the polyglutimide compounds represented by Formula (2), wherein W is a water-solubilizing/dispersing moiety that provides water-solubility and/or water-dispersibility to the polyimido compound; the ratio of n to n 2 is from about 1 :99 to about 99:1 ; and the molecular weight of the polyimido compound is from about 300 to about 1 ,000,000. This invention also pertains to a proteinaceous substrate, having a polyimido compound covalently bonded to a portion thereof, wherein the polyimido compound is derived from a residue selected from the group consisting of polysuccinimide compounds represented by Formula (1): I 1 w L J n, L ' n 2 (1) polyglutimide compounds represented by Formula (2); I 1 w n, . (2) and copolymers of the polysuccinimide compounds represented by Formula (1) with the polyglutimide compounds represented by Formula (2); wherein W is a water-solubilizing/dispersing moiety that provides water-solubility and/or water-dispersibility to the polyimido compound; the ratio of n^ to n 2 is from about 1 :99 to about 99:1 ; and the molecular weight of the polyimido compound is from about 300 to about 1 ,000,000. This invention also pertains to a method for treating a proteinaceous substrate which comprises the steps of: (a) contacting a proteinaceous substrate with an aqueous solution/dispersion of an imido or polyimido compound at a pH value between about 4 and about 7 for a time sufficient to allow the imido or polyimido compound to be adsorbed/absorbed on or into the proteinaceous substrate; and (b) raising the pH value of the imido or polyimido compound adsorbed/absorbed on or into the proteinaceous substrate above about 7 for a time sufficient to allow the imido or polyimido compound to react with the proteinaceous substrate. This invention also pertains to a method for treating a proteinaceous substrate which comprises the steps of: (a) contacting a proteinaceous substrate with an aqueous solution of a polyimido compound at a pH value between about 4 and about 7 for a time sufficient to allow the polyimido compound to be adsorbed/absorbed on or into the proteinaceous substrate; and (b) raising the pH value of the polyimido compound adsorbed/absorbed on or into the proteinaceous substrate above about 7 for a time sufficient to allow the polyimido compound to react with the proteinaceous substrate; wherein the polyimido compound is selected from the group consisting of polysuccinimide compounds represented by Formula (1): I w J n, L ' n 2 (1) polyglutimide compounds represented by Formula (2); (2) and copolymers of the polysuccinimide compounds represented by Formula (1) with the polyglutimide compounds represented by Formula (2), wherein W is a water-solubilizing/dispersing moiety that provides water-solubility and/or water-dispersibility to the polyimido compound; the ratio of ^ to n 2 is from about 1:99 to about 99:1 ; and the molecular weight of the polyimido compound is from about 300 to about 1 ,000,000. DETAILED DESCRIPTION OF THE INVENTION The present invention is directed to water-soluble/dispersible reactive derivatives of polyimido compounds useful for modifying proteinaceous substrates such as hair, wool, skin, leather, silk, fur, felt, and nails. Applicants have found that reaction of a portion of the imide groups in the water-insoluble polysuccinimide (or polyglutimide) with a water- solubilizing/dispersing nucleophilic agent yields a water-soluble/dispersible polymer containing reactive sites at the remaining imide moieties. This water-soluble/dispersible polyimide, containing reactive imide moieties, is a water-soluble/dispersible acylating agent which can be covalently reacted with various nucleophilic groups present on the proteinaceous substrate to permanently impart changes to these substrates. Because of the unique and unexpected properties of the polyimido acylating agents of the present invention, the polyimido compounds can be used in applications to provide permanent modification of proteinaceous substrates such as hair and skin under aqueous conditions. In another embodiment, the polyimido acylating agents can be further reacted with a multifunctional nucleophilic agent to promote the development of cross-linked polymers to further modify the proteinaceous substrate. In yet another embodiment, the proteinaceous substrate may be bonded to a polyimido acylating agent having a water- solubilizing/dispersing moiety bearing a strong ionic charge which can electrostatically bind to moieties bearing the opposite charge. By priming the proteinaceous substrate with a highly charged polymer, one can modify the surface of the proteinaceous substrate to make it attract chemical moieties of the opposite charge and thereby impart a wide variety of beneficial properties to the proteinaceous substrate. Moreover, many of the polyimido compounds, upon reaction, revert to biodegradable and environmentally friendly compounds. The present invention is also directed to a method for treating and/or modifying a proteinaceous substrate. The method comprises contacting a proteinaceous substrate with an aqueous solution of a polyimido compound at a pH value between about 4 and about 7 for a time sufficient to allow the polyimido compound to be adsorbed/absorbed on or into the proteinaceous substrate; followed by raising the pH value of the polyimido compound adsorbed/absorbed on or into the proteinaceous substrate above about 7 for a time sufficient to allow the polyimido compound to react with the proteinaceous substrate. The polyimido compound is best applied to the proteinaceous substrate in a two step, pH dependent method. The polyimido compound is first applied to the proteinaceous substrate at a pH value between about 4 and about 7, wherein the polyimido compound is relatively stable. Moreover, the aqueous solution of polyimido compound must be in contact for a time sufficient to allow the polyimido compound to be adsorbed/absorbed on or into the proteinaceous substrate. Thereafter, the pH value of the polyimido compound adsorbed/absorbed on or into the proteinaceous substrate is raised to above about 7 (preferably 8-10) for a time sufficient to allow the polyimido compound to react with the proteinaceous substrate. The pH value of the polyimido compound must be raised to above about 7 in order to deprotonate nucleophilic groups (amino groups, alcohol groups, phenolic groups, sulfhydryl groups, and carboxyl groups) present on the proteinaceous substrate which may then readily react with the reactive polyimido compound. The polyimido compound, at pH above about 7, must also be in contact with the proteinaceous substrate for a time sufficient to allow the polyimido compound to react with the proteinaceous substrate. The time sufficient to allow the polyimido compound to be adsorbed/absorbed on or into the proteinaceous substrate and the time sufficient to allow the polyimido compound to react with the proteinaceous substrate are subject to such factors as the particular type of polyimido compound used, the water-solubilizing/dispersing moiety employed, the proteinaceous substrate employed, the temperature of the application, the resulting properties desired, as well as the particular application for which the compound may be used. In general, the time sufficient to allow the polyimido compound to be adsorbed/absorbed on or into the proteinaceous substrate and the time sufficient to allow the polyimido compound to react with the proteinaceous substrate may range from seconds to an hour. Condensation of aspartic acid in the presence of an acid catalyst such as H 3 PO yields the water-insoluble polysuccinimide. HOOCCH2CH(NH2)COOH H3P 4 Aspartic Acid Polysuccinimide Partial reaction of the succinimide groups in polysuccinimide with a water-solubilizing/dispersing nucleophilic agent (W), usually carried out in an aprotic solvent such as dimethylsulfoxide, sulfolane, or dimethylformamide, results in the formation of a water-soluble/dispersible polymer containing reactive sites at the remaining succinimide moieties. (1) In accord with the present invention, a polyimido compound is provided which is selected from the group consisting of polysuccinimide compounds represented by Formula (1): 1 1 w -l nι L ' n 2 (1) polyglutimide compounds represented by Formula (2); (2) and copolymers of the polysuccinimide compounds represented by Formula (1) with the polyglutimide compounds represented by Formula (2), and mixtures thereof. In Formula (1) and (2), W is a water-solubilizing/dispersing moiety that provides water-solubility and/or water-dispersibility to the polyimido compound. The water-solubilizing/dispersing moieties which may be employed in the present invention include all moieties which can covalently react with the polyimido compound and provide water-solubility and/or water- dispersibility to the polyimido compound. In a preferred embodiment, the nucleophilic water-solubilizing/dispersing moieties may be derived from a nucleophilic moiety selected from the group consisting of amines, alcohols, phenols, thiols, and carboxylates. Preferably, W is the result of reacting a polyimido compound with an amine. Preferred water-solubilizing/dispersing moieties may be selected from the group of nucleophiles consisting of: (1) aminopolysaccharides preferably represented by the formula, -N(R 1 )- polysaccharide, wherein Ri is hydrogen or lower alkyl (C, to C 5 ) and the number of units in the polysaccharide ranges from 1 to about 51. Substitution of from about 0.10 to about 0.80 equivalents of the polysaccharide, based on the available imide moieties, is generally required for solubilization. An example of a polyimido compound containing a maltodextrin aminopolysaccharide water-solubilizing/dispersing moiety is set out below. N(CH 3 ) I -I n, L ' n 2 maltodextrin (1) (2) amines containing quaternary ammonium salts preferably represented by the formula, [-N(R 1 )(CH 2 ) n3 N + (CH 3 )3][A " ], wherein R, is hydrogen or lower alkyl (C, to C 5 ), n 3 is an integer from 1 to about 10, preferably from 1 to about 7, and A is a monovalent anion. Substitution of from about 0.10 to about 0.80 equivalents of the amino containing quaternary ammonium salt, based on the available imide moieties, is generally required for solubilization. An example of a polyimido compound containing an amino containing quaternary ammonium salt water-solubilizing/dispersing moiety is set out below. I NH I ri ! n 2 (CH 2 ) 3 N + (CH 3 ) 3 I ' (1) (3) amines containing alcohols preferably represented by the formula, -N(R 1 )(CH 2 ) n4 OH, wherein R, is hydrogen or lower alkyl (C, to C 5 ) and n 4 is an integer from 2 to about 10, preferably from 2 to about 7. Substitution of from about 0.10 to about 0.80 equivalents of the amino containing alcohol, based on available imide moieties, is generally required for solubilization. An example of a polyimido compound containing an amino containing alcohol water-solubilizing/dispersing moiety is set out below. (1) (4) amines containing polyalkoxylated alcohols preferably represented by the formula, -N(R 1 )CH(CH 3 )CH 2 -(OCHR 2 CH 2 ) n5 -OCH 3 , wherein R, is hydrogen or lower alkyl (C, to C 5 ), R 2 may be hydrogen or methyl, and n 5 is an integer from 0 to about 50, preferably from 0 to about 35. Substitution of from about 0.10 to about 0.80 equivalents of the amino containing polyalkoxylated alcohol, based on available imide moieties, is generally required for solubilization. (5) thiols containing alcohols preferably represented by the formula, - S(CH 2 ) n6 OH, wherein n 6 is an integer ranging from 2 to about 10 preferably from 3 to about 7. Substitution of from about 0.10 to about 0.80 equivalents of the thiol terminated compound, based on available imide moieties, is generally required for solubilization. (6) alcohols containing ethers preferably represented by the formula, -O(CH 2 CH 2 O) n7 OM, wherein n 7 is an integer ranging from 0 to about 50, preferably from 0 to about 35, and M is an alkyl group containing from 1 to about 30 carbons, preferably from 1 to about 20,. Substitution of from about 0.10 to about 0.80 equivalents of the hydroxyl terminated compound, based on available imide moieties, is generally required for solubilization. (7) -O " X + , where X is selected from the group consisting of H + , Na + , Li + , NH 4 + , NH(CH 3 ) 3 + ; NH 3 (CH 2 CH 2 OH) + , NH 2 (CH 2 CH 2 OH) 2 + , and NH(CH 2 CH 2 OH) 3 + ; such as when the water-solubilizing/dispersing moiety is the result of ring opening of some of the imide groups with aqueous bases such as NaOH or NH 4 OH. An example of a polyimido compound containing this type of water-solubilizing/dispersing moiety is set out below. i r -CHCONH- -CH-CO I CH 2 I N- I I I C(O) CH 2 -CO I ONa -I n, L ' n 2 (1 ) (8) [-NH(CH 2 ) 3 N + (CH 3 ) 2 CH 2 COONa][A ], -N(CH 3 )(CH 2 ) 2 SO 3 Na (N-methyltaurine), and -NH(CH 2 ) 2 SO 3 Na (taurine), wherein A is a monovalent anion, including other anionic, amphoteric, or zwitterionic water-solubilizing groups. Residues n, and n 2 in Formula (1) and (2) may be present in any order. The ratio of n, to n 2 is from about 1 :99 to about 99:1 ; preferably from about and 5:95 to about 95:5, and more preferably from about 10:90 to about 90:10. The molecular weight of the polyimido compounds is a matter of preference subject to such factors as the particular type of polyimido compound used, the type and charge characteristics of the water- solubilizing/dispersing moiety employed, the proteinaceous substrate employed, the resulting properties desired, as well as the particular application for which the compound may be used. In general, for internal modifications of proteinaceous substrates, the molecular weight of the polyimido compound will be under about 5000 and the water- solubilizing/dispersing moiety will be neutral or amphoteric (with a net neutral charge). In general, for external modifications of proteinaceous substrates, the molecular weight of the polyimido compound may be under or over 5000. However, polyimido compounds having a molecular weight over 5000 and cationic water-solubilizing/dispersing moieties will tend to remain on the surface rather than penetrate the proteinaceous substrate. However, techniques such as swelling the proteinaceous substrate may be employed to internally modify the proteinaceous substrate with polyimido compounds of higher molecular weight. In one embodiment, the molecular weight of the polyimido compound in Formula (1) and (2) is from about 300 to about 5000, preferably from about 1000 to about 4000; more preferably from about 1000 to about 3000; and most preferably from about 1000 to about 2000. In another embodiment, the molecular weight of the polyimido compound in Formula (1) and (2) is from about 5000 to about 1 ,000,000, preferably from about 5000 to about 500,000; more preferably from about 5000 to about 100,000; and most preferably from about 5000 to about 50,000. In one preferred embodiment, the polyimido compound is a polysuccinimide represented by Formula (1). In another preferred embodiment, the polyimido compound is a polyglutimide represented by Formula (2). In yet another preferred embodiment, the polyimido compound is a copolymer of the polysuccinimide represented by Formula (1) (before derivatization) with the polyglutimide represented by Formula (2) (before derivatization). The scope of the present invention need not be limited to polyimido compounds such as polysuccinimide compounds, polyglutimide compounds, and copolymers thereof, but may also include imido compounds. The imido compounds may be water-soluble or water-dispersible natural or synthetic polymers to which reactive imide moieties such as succinimide, glutimide, or phthalimide groups have been appended or, into the backbones of which, reactive imide moieties have been incorporated to form imido compounds. These imido compounds can be prepared by copolymerization reactions or by polymer modification reactions. In a specific embodiment, the present invention is directed to a method for treating a proteinaceous substrate which comprises the steps of: (a) contacting a proteinaceous substrate with an aqueous solution/dispersion of an imido or polyimido compound at a pH value between about 4 and about 7 for a time sufficient to allow the imido or polyimido compound to be adsorbed/absorbed on or into the proteinaceous substrate; and (b) raising the pH value of the imido or polyimido compound adsorbed/absorbed on or into the proteinaceous substrate above about 7 for a time sufficient to allow the imido or polyimido compound to react with the proteinaceous substrate. After reaction of a portion of the imide groups of the water-insoluble reactive polyimide, the water-soluble/dispersible polymer can now act as an acylating agent which can be covalently and permanently bonded to various nucleophilic groups present on a proteinaceous substrate. The proteinaceous substrates which may be employed in the present invention include all substrates containing nucleophilic groups which can covalently react with the polyimido acylating compounds. Suitable nucleophilic groups include amino groups, alcohol groups, phenolic groups, sulfhydryl groups, and carboxyl groups. Preferred proteinaceous substrates may be selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails. The polyimido acylating compounds of the present invention may be employed in a pharmaceutically acceptable carrier to form therapeutic compositions. Suitable pharmaceutically acceptable carriers may be selected from the group consisting of water, water/alcohol mixtures, water/glycol mixtures, and mixtures thereof. Preferably, the pharmaceutically acceptable carrier is water. The amount of polyimido compound present in the therapeutic compositions of the present invention is a therapeutically effective amount, that is, an amount effective to impart the modification properties desired. A therapeutically effective amount of polyimido compound is that amount of polyimido compound necessary for the inventive compound to provide the desired therapeutic effect. The exact amount of polyimido compond is a matter of preference subject to such factors as the particular type of polyimido compound, the molecular weight of the polyimido compound employed, the temperature of the application, the resulting properties desired, as well as the particular application for which the therapeutic composition may be used, i.e, substrate type, application, conditions, end-use. In a preferred embodiment, the polyimido compound in the pharmaceutically acceptable carrier is present in an amount from about 1% to about 70%, preferably from about 5% to about 65%, and more preferably from about 10% to about 60%, by weight. In a specific embodiment, the present invention is directed to a proteinaceous substrate, having a polyimido compound covalently bonded to a portion thereof, wherein the polyimido compound is derived from a residue selected from the group consisting of polysuccinimide compounds represented by Formula (1): i r -CHCONH- -CH-CO I CH 2 I N- I C(O) CH 2 -CO I w ' n 2 (1) polyglutimide compounds represented by Formula (2); n 2 (2) and copolymers of the polysuccinimide compounds represented by Formula (1) with the polyglutimide compounds represented by Formula (2); wherein W is a water-solubilizing/dispersing moiety that provides water-solubility and/or water-dispersibility to the polyimido compound; the ratio of ni to n 2 is from about 1:99 to about 99:1 ; and the molecular weight of the polyimido compound is from about 300 to about 1 ,000,000. In another specific embodiment, the present invention is directed to a method for treating a proteinaceous substrate which comprises the steps of: (a) contacting a proteinaceous substrate with an aqueous solution of a polyimido compound at a pH value between about 4 and about 7 for a time sufficient to allow the polyimido compound to be adsorbed/absorbed on or into the proteinaceous substrate; and (b) raising the pH value of the polyimido compound adsorbed/absorbed on or into the proteinaceous substrate above about 7 for a time sufficient to allow the polyimido compound to react with the proteinaceous substrate; wherein the polyimido compound is selected from the group consisting of polysuccinimide compounds represented by Formula (1): - I w -i n, L ' n 2 (1) polyglutimide compounds represented by Formula (2); | 1 w n, L ! n 2 (2) and copolymers of the polysuccinimide compounds represented by Formula (1) with the polyglutimide compounds represented by Formula (2), wherein W is a water-solubilizing/dispersing moiety that provides water-solubility and/or water-dispersibility to the polyimido compound; the ratio of n, to n 2 is from about 1:99 to about 99:1 ; and the molecular weight of the polyimido compound is from about 300 to about 1 ,000,000. In these latter two embodiments, suitable non-limiting proteinaceous substrates may be selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails. The polyimido compound may further be cross-linked to a multifunctional nucleophilic agent such as nucleophilic agents selected from the group consisting of 1, 6-hexamethylenediamine, low-molecular weight polyethyleneimines, polyalkoxides, and polythiols. The water-solubilizing/dispersing moiety may further bear an ionic charge and be electrostatically bound to a moiety bearing the opposite charge such as those moieties selected from the group consisting of antimicrobials, ultraviolet chromophores, anionic dyes, anti-oxidants, fluorescing agents, brightening agents, shine and gloss enhancers, softening agents, and conditioning agents. In addition, the methods for treating a proteinaceous substrate may be carried out at elevated temperatures, such as from about 25°C to about 55°C, to accelerate the reaction method. In a preferred method of the present invention, beneficial modifications can be made to proteinaceous substrates in a fashion that resists washout by using an improved two step method employing water-soluble/dispersible imido or polyimido compounds. In this method, an aqueous solution of water- soluble/dispersible imido or polyimido compound is prepared and applied to a proteinaceous substrate, such as hair, for a time sufficient at a temperature sufficient to allow the imido or polyimido compound to be adsorbed/absorbed on or into the proteinaceous substrate. Following this time, a solution with pH>7 is applied to the proteinaceous substrate. The solution of the second step is chosen by selecting solvent(s) having pH >7 in which the water- soluble/dispersible imido or polyimido compound is substantially insoluble. Such a solution can optionally contain other ingredients typically employed in pharmaceutically acceptable carriers. By performing the second step, the pH modification step, with a solution in which the water-soluble/dispersible imido or polyimido compound is substantially insoluble, one can obtain a more efficacious modification of the substrate. This invention is particularly useful for those benefits that are strongly dependent on the quantity of polymer being delivered to the substrate. The selection of a solvent(s) having pH >7 in which the water- soluble/dispersible imido or polyimido compound is substantially insoluble can be guided by calculating the solubility parameter of the imido or polyimido compound by any of the well known techniques, for example see Barton, A.F.M., CRC Handbook of Solubility Parameters and Other Cohesion Parameters, 2 nd edition, CRC Press, NY, 1991. A solvent may be selected by choosing single solvents or combinations of solvents that demonstrate a solubility parameter such that the polymer will be insoluble according to the guidelines of the specific solubility parameter technique. Guided by these calculations, experiments can be performed to identify the preferred solvent. Suitable solvents are those in which the imido or polyimido compound is less than about 50% soluble, preferably those in which the imido or polyimido compound is less than about 10%, more preferably those in which the imido or polyimido compound is less than about 5% soluble, and most preferably those in which the imido or polyimido compound is less than about 1% soluble. As set out above, the scope of the present invention need not be limited to polyimido compounds such as polysuccinimide compounds, polyglutimide compounds, and copolymers thereof, but may also include imido compounds. The imido compounds may be water-soluble or water-dispersible natural or synthetic polymers to which reactive imide moieties such as succinimide, glutimide, or phthalimide groups have been appended or, into the backbones of which, reactive imide moieties have been incorporated to form imido compounds. These imido compounds can be prepared by copolymerization reactions or by polymer modification reactions. In a preferred embodiment, the present invention is directed to a method for treating a proteinaceous substrate which comprises the steps of: (a) contacting a proteinaceous substrate with an aqueous solution/dispersion of an imido or polyimido compound at a pH value between about 4 and about 7 for a time sufficient to allow the imido or polyimido compound to be adsorbed/absorbed on or into the proteinaceous substrate; and (b) raising the pH value of the imido or polyimido compound adsorbed/absorbed on or into the proteinaceous substrate above about 7 for a time sufficient to allow the imido or polyimido compound to react with the proteinaceous substrate. In this embodiment, preferably, the molecular weight of the imido or polyimido compound is from about 300 to about 1,000,000; the proteinaceous substrate is selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails; and the pH value of the imido or polyimido compound adsorbed/absorbed on or into the proteinaceous substrate in step (b) is raised above about 7 employing a solvent in which the imido or polyimido compound is substantially insoluble. In another preferred embodiment, the present invention is directed to a proteinaceous substrate having an imido or polyimido compound covalently bonded to a portion thereof. Preferably, the molecular weight of the imido or polyimido compound is from about 300 to about 1 ,000,000, and the proteinaceous substrate is selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails. In another preferred embodiment, the present invention is directed to a method for treating a proteinaceous substrate which comprises the steps of: (a) contacting a proteinaceous substrate with an aqueous solution of an imido compound at a pH value between about 4 and about 7 for a time sufficient to allow the imido compound to be adsorbed/absorbed on or into the proteinaceous substrate; and (b) raising the pH value of the imido compound adsorbed/absorbed on or into the proteinaceous substrate above about 7 for a time sufficient to allow the imido compound to react with the proteinaceous substrate; wherein the imido compound is represented by Formula (3): wherein W, is a water-solubilizing/dispersing moiety that provides water- solubility and/or water-dispersibility to the imido compound; R 3 is selected from the group consisting of hydrogen, Cι-C 12 branched and unbranched alkyl, aryl, aralkyl, and alkaryl; Y is the residue of an ethylenically unsaturated hydrophilic monomer that provides water-solubility and/or water-dispersibility to the imido compound; Z is the residue of an ethylenically unsaturated monomer that provides structural units to the imido compound; the molecular weight of the imido compound is from about 300 to about 2,000,000; n 8 is from about 0 to about 100; n 9 is from about 0 to about 99; n 10 is from about 0 to about 99; and nn is from about 0 to about 99; with the proviso that when n 8 is zero, n 9 and n 10 are not zero. In Formula (3), Y is the residue of an ethylenically unsaturated hydrophilic monomer that is incorporated into the polyimido compound in order to impart water solubility or water dispersibility to the polymer. Suitable hydrophilic monomers include those monomers that are ionic, e.g. anionic, cationic, or zwitterionic, or have sufficient nonionic polar functionality, e.g. hydroxyl or amido groups to render them hydrophilic. Anionic monomers typically contain carboxylic, sulfonic, and/or phosphonic acid functionality. Exemplary anionic monomers include, without limitation, (meth)acrylic acid and the alkali, alkaline earth or ammonium salts thereof, crotonic acid and the alkali, alkaline earth or ammonium salts thereof, dicarboxylic acid containing monomers such as maleic, fumaric and itaconic acids including the anhydrides and the alkali, alkaline earth or ammonium salts thereof, the half esters of unsaturated dicarboxylic acids such as methyl hydrogen fumarate, butyl hydrogen fumarate, ethyl hydrogen maleate, and butyl hydrogen maleate and the alkali, alkaline earth or ammonium salts thereof, the allyloxy-benzene-sulfonate monomers described in United States patent no. 4,892,898, which disclosure is incorporated by reference herein, methallylsulfonate and the alkali, alkaline earth or ammonium salts thereof, styrene sulfonic acid and the alkali, alkaline earth or ammonium salts thereof, acrylamido alkyl or aryl sulfonates such as 2-acrylamido-2-methyl propane sulfonic acid and the alkali, alkaline earth or ammonium salts thereof, vinyl sulfonic acid and the alkali, alkaline earth or ammonium salts thereof, and vinyl phosphonic acid and the alkali, alkaline earth or ammonium salts thereof. Cationic monomers typically contain amine or quaternary ammonium functionality. Exemplary cationic monomers include, without limitation, (3-acrylamidopropyl)trimethylammonium chloride, [2-(acryloyloxy)ethyl]- trimethylammonium methyl sulfate, 2-(dimethylamino)ethyl acrylate, [3-(methacryloylamino)propyl]trimethylammonium chloride, [2-(methacryloyloxy) ethyljtrimethylammonium chloride, [2-(methacryloyloxy)- ethyljtrimethylammonium methyl sulfate, 2-(dimethylamino)ethyl methacrylate, 2-aminoethyl methacrylate hydrochloride, diallyldimethyl- ammonium chloride, vinyl imidazole, vinyl pyridine and substituted derivatives thereof, and quaternized vinyl pyridine. Zwitterionic monomers typically consist of, without limitation, unsaturated carboxyl, sulfoxyl or sulfate-substituted amines, and are commonly referred to as betaines. Exemplary zwitterionic monomers include, without limitation, [3-(methacryloylamino)propyl]dimethyl(3-sulfopropyl)ammonium hydroxide inner salt and [2-(methacryloyloxy)ethyl]dimethyl(3-sulfopropyl)ammonium hydroxide, inner salt hydrate. Exemplary monomers that have sufficient nonionic polar functionality to render them hydrophilic include, without limitation C^ hydroxy alkyl esters of (meth)acrylic acid, e.g. 2-hydroxyethyl acrylate, and hydroxypropyl acrylate, 2-hydroxyethyl methacrylate, hydroxypropyl methacrylate, vinyl formamide, vinyl acetamide, 1-vinyl-2-pyrrolidinone, methacrylamide, acrylamide, C^ mono- and dialkyl substituted (meth)acrylamides, e.g. N,N-dimethylacrylamide and N-isopropylacrylamide, acrylonitrile, and methacrylonitrile. Other exemplary monomers that have sufficient nonionic polar functionality to render them hydrophilic include polymerizable saccharide- derived monomers, examples of which are described in United States patent no. 5,563,252, which disclosure is incorporated by reference herein. In general, polymerizable, saccharide-derived monomers comprise a single, polymerizable alpha-methyl styryl moiety. Methods used to prepare the saccharide monomers utilize only water as the reaction solvent and preferably are free of a cosolvent. In one embodiment, the process comprises mixing together, in water and in the absence of a cosolvent, a saccharide with an amine of the formula R 3 NH 2 , wherein R 3 may be Cι-Cι 8 alkyl, H or NH 2 . The admixture of the saccharide and the amine are contacted with pressurized hydrogen, in the presence of a Group VIIIB metal catalyst and under conditions effective to produce an amino saccharide structure. The amino saccharide is reacted with 3-isopropenyl-alpha, alpha- dimethylbenzylisocyanate to form a saccharide monomer structure. Y can also be the residue of vinyl alcohol. Vinyl alcohol residues are typically introduced by copolymerization of a vinyl ester such as vinyl acetate followed by hydrolysis or transesterification with an excess of alcoholic solvent. Particularly suitable hydrophilic monomers that are used to make up the Y group include [3-(methacryloylamino)propyl]trimethylammonium chloride, diallyldimethylammonium chloride, methacrylic acid, acrylic acid, 2- acrylamido-2-methyl propane sulfonic acid and the alkali, alkaline earth or ammonium salts thereof, and polymerizable saccharide-derived monomers saccharide monomers of the type described in United States patent no. 5,563,252, which disclosure is incorporated by reference herein. In Formula (3), Z is the residue of an ethylenically unsaturated monomer that provides structural units for the polyimido compound. Examples of such monomers include but are not limited to those selected from the group consisting of the esters and amides of acrylic acid and methacrylic acid with alcohols, phenols, and amines; the vinyl aromatic compounds, e.g. styrene, alpha-methylstyrene and substituted derivatives thereof such as the halogenated derivatives thereof and vinyl toluene; the vinyl esters and vinyl amides, e.g. vinyl acetate and 1-vinyl-2-pyrrolidinone; the vinyl ethers, e.g. methylvinyl ether, butyl vinyl ether; ethylenically unsaturated nitriles, e.g. acrylonitrile, and combinations thereof; and olefins, e.g. 1-butene and 1 ,3, butadiene Monomers that are particularly well suited to provide structural units for the polyimido compound are the Ci to C alkyl esters of acrylic acid and methacrylic acid, vinyl ethers, vinyl esters, and styrene. Preferred imido compounds represented by Formula (3) are imido compounds wherein n 8 is 33 mole% (1-99 mole%, 10-90 mole%, 25-75 mole%) wherein W, is -CH 2 CH 2 CH 2 N + (CH 3 ) 3 A, wherein A is CI " or another monovalent anion; n 9 is 0 mole%, n 10 is 0 mole%, and nn is 67 mole%, wherein Z is styrene. Other preferred imido compounds represented by Formula (3) are imido compounds wherein n 8 is 0 mole%; n 9 is about 50 mole%, wherein R 3 is -CH 2 CH 3 or another C C 4 alkyl group; nι 0 is about 50 mole% and Y is [3-(methacryloylamino)propyl]trimethylammonium chloride; and nn is 0 mole%. In a preferred embodiment, W, is a hydrophilic group selected from the group consisting of anionic, cationic, zwitterioinc, and polar non-ionic functional groups. Preferably, W, is selected from the group consisting of: (1) saccharides or polysaccharides wherein the number of units in the polysaccharide ranges from 1 to about 51 ; (2) quaternary ammonium salts represented by the formula, [(CH 2 ) n3 N + (CH 3 ) 3 ][A " ], wherein n 3 is an integer from 1 to about 10 and A is a monovalent anion; (3) alcohols represented by the formula, (CH 2 ) n4 OH, wherein n 4 is an integer from 2 to about 10; (4) polyalkoxylated alcohols represented by the formula, -CH(CH 3 )CH 2 -(OCHR 2 CH 2 ) n5 -OCH 3 , wherein R 2 may be hydrogen or methyl, and n 5 is an integer from 0 to about 50; and (5) [- (CH 2 ) 3 N + (CH 3 ) 2 CH 2 COONa][A-], [-(CH 2 ) 3 N + (CH 3 ) 2 CH 2 CH 2 CH 2 SO 3 Na][A-], -(CH 3 )(CH 2 ) 2 SO 3 Na, and -(CH 2 ) 2 SO 3 Na, wherein A is a monovalent anion. Preferably, R 3 is a C C branched or unbranched alkyl group. Preferably, Y is selected from the group consisting of anionic, cationic, zwitterionic, and nonionic monomers. More preferably, Y is selected from the group of anionic monomers consisting of (meth)acrylic acid, crotonic acid, maleic acid, fumaric acid, itaconic acid, maleic anhydride, fumaric anhydride, itaconic anhydride, methyl hydrogen fumarate, butyl hydrogen fumarate, ethyl hydrogen maleate, butyl hydrogen maleate, allyloxy-benzene-sulfonate monomers, methallylsulfonate, styrene sulfonic acid, acrylamido alkyl sulfonates, aryl sulfonates, vinyl sulfonic acid, vinyl phosphonic acid, and the alkali, alkaline earth, and ammonium salts thereof. More preferably, Y is selected from the group of cationic monomers consisting of (3- acrylamidopropyl) trimethylammonium chloride, [2-(acryloyloxy)ethyl] trimethylammonium methyl sulfate, 2-(dimethylamino) ethyl acrylate, [3- (methacryloylamino)propyl] trimethylammonium chloride, [2- (methacryloyloxy)ethyl] trimethylammonium chloride, [2- (methacryloyloxy)ethyl] trimethylammonium methyl sulfate, 2- (dimethylamino)ethyl methacrylate, 2-aminoethyl methacrylate hydrochloride, diallyl-dimethyl-ammonium chloride, vinyl imidazole, vinyl pyridine including substituted derivatives thereof, and quaternized vinyl pyridine. More preferably, Y is selected from the group of zwitterionic monomers consisting of unsaturated carboxyl, sulfoxyl, and sulfate-substituted amines. More preferably, Y is selected from the group of nonionic monomers consisting of d^ hydroxy alkyl esters of (meth)acrylic acid, vinyl formamide, vinyl acetamide, 1-vinyl-2-pyrrolidinone, methacrylamide, acrylamide, C^ mono- and dialkyl substituted (meth)acrylamides, acrylonitrile, methacrylonitrile, and polymerizable saccharide-derived monomers. In another embodiment, Y is the residue of an ethylenically unsaturated hydrophilic vinyl alcohol monomer. Most preferably, Y is selected from the group consisting of [3- (methacryloylamino)propyl] trimethylammonium chloride, diallyl-dimethyl- ammonium chloride, methacrylic acid, acrylic acid, 2-acrylamido-2-methyl propane sulfonic acid, polymerizable saccharide-derived monomers, and the alkali, alkaline earth, and ammonium salts thereof. Preferably, Z is selected from the group consisting of esters and amides of acrylic acid and methacrylic acid, vinyl aromatic compounds, vinyl esters, vinyl amides, vinyl ethers, ethylenically unsaturated nitriles, 1-butene, 1,3, butadiene, and substituted derivatives thereof. More preferably, Z is selected from the group consisting of C 1-4 alkyl esters of acrylic acid and methacrylic acid, vinyl ethers, vinyl esters, and styrene. In one embodiment, the molecular weight of the imido compound is from about 300 to about 5,000. In another embodiment, the molecular weight of the imido compound is greater than about 5,000. In one embodiment, n 8 is from about 1 to about 99; n 9 is from about 0 to about 99; n is from about 0 to about 99; and nn is from about 1 to about 99. In another embodiment, wherein n 8 is from about 0 to about 99; n 9 is from about 1 to about 99; n 10 is from about 1 to about 99; and nn is from about 0 to about 99. Preferably, the proteinaceous substrate is selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails. In one embodiment, the imido compound is cross-linked with a multifunctional nucleophilic agent which is preferably selected from the group consisting of 1 , 6-hexamethylenediamine, polyethyleneimines, polyalkoxides, and polythiols. In another embodiment, the water-solubilizing/dispersing moiety bears an ionic charge and is electrostatically bound to a moiety bearing the opposite charge, wherein the moiety bearing the opposite charge is preferably selected from the group consisting of antimicrobials, ultraviolet chromophores, anionic dyes, anti-oxidants, fluorescing agents, brightening agents, shine and gloss enhancers, softening agents, and conditioning agents. In a preferred embodiment, the pH value of the imido compound adsorbed/absorbed on or into the proteinaceous substrate in step (b) is raised above about 7 employing a solvent in which the imido compound is substantially insoluble. More preferably, the solvent employed is selected from the group consisting of C 2 -C 3 alcohols, aqueous mixtures of C 2 -C 3 alcohols, and mixtures thereof. The present invention is also directed to a proteinaceous substrate, having an imido compound covalently bonded to a portion thereof, wherein the imido compound is derived from a residue represented by Formula (3). The present invention is also directed to imido compounds represented by Formula (3). Preferred imido compounds of Formula (3) are imido compounds wherein W, is selected from the group consisting of hydroxyalkyls, polyhydroxyalkyls, and saccharides. Other preferred imido compounds of Formula (3) are imido compounds wherein Y is [3-(methacryloylamino)propyl] trimethylammonium chloride. In another preferred embodiment, the present invention is directed to a method for treating a proteinaceous substrate which comprises the steps of: (a) contacting a proteinaceous substrate with an aqueous solution of an imido compound at a pH value between about 4 and about 7 for a time sufficient to allow the imido compound to be adsorbed/absorbed on or into the proteinaceous substrate; and (b) raising the pH value of the imido compound adsorbed/absorbed on or into the proteinaceous substrate above about 7 for a time sufficient to allow the imido compound to react with the proteinaceous substrate; wherein the imido compound is represented by Formula (4): R (4) wherein R 4 is independently selected from the group consisting of hydrogen, C C 12 branched and unbranched alkyl, aryl, aralkyl, and alkaryl; n 15 is 1 or 2, or both; R 5 and R 6 are independently selected from the group consisting of hydrogen, CrC 12 branched and unbranched alkyl, aryl, aralkyl, and alkaryl, or together are -CH=CHCH=CH-; R 7 is independently selected from the group consisting of hydrogen, C C 12 branched and unbranched alkyl, aryl, aralkyl, alkaryl, and -CH 2 CH 2 CH 2 (OCH 2 CH 2 )ni 6 CH 2 OH, wherein nι 6 is from 1 to about 100; is a divalent linking group selected from the group consisting of alkylene, oxyalkylene, polyoxyalkylene, iminoalkylene, polyiminoalkylene, phenylene, and alkylene phenylene; the molecular weight of the imido compound is from about 300 to about 2,000,000; n 12 is from about 0 to about 100; n 13 is from about 0 to about 99; and n 1 is from about 0 to about 99; with the proviso that when n 12 is zero, n 13 is not zero. In Formula (4), n 12 n 13 , and n 14 represent the mole percent of the respective repeating unit, n 12 is 0 to 100, n 13 is 0 to 100, and n 1 is 0 to 99, with the proviso that if n, 2 is 0, nι 3 cannot be 0; each R 7 is independently selected from the group consisting of C C 12 linear or branched alkyl, phenyl, alkyl phenyl, and -CH 2 CH 2 CH 2 -(O-CH 2 CH 2 -) n16 CH 2 -OH, wherein n 16 is 1 to 100; each R 4 is independently selected from the group consisting of hydrogen, C C 12 linear or branched alkyl, phenyl, or alkyl phenyl; n 15 = 1 or 2; R 5 and R 6 are independently selected from the group consisting of hydrogen, Cι-Cι 2 linear or branched alkyl, phenyl, or alkyl phenyl or R 5 and R 6 together are -CH=CHCH=CH-; and is a divalent linking group selected from the group consisting of alkylene, oxyalkylene, polyoxyalkylene, iminoalkylene, polyiminoalkylene, phenylene, and alkylene phenylene. In preferred compositions, n 12 , n 13 , and n 14 are as above and each R 7 is independently selected from the group consisting of methyl, phenyl, and -CH 2 CH 2 CH 2 -(O-CH 2 CH 2 -) n16 CH 2 -OH, wherein n 16 is 1 to 100, each R 4 is H; n 15 = 1 ; R 5 and R 6 are both H or R 5 and R 6 together are -CH=CHCH=CH-; and L, is an alkylene group having from 1 to 12 carbon atoms or -CH 2 CH 2 CH 2 (OCH 2 CH 2 ) n17 CH 2 -, wherein n 17 is from 1 to about 100. In more preferred compositions, (1) n 12 is about 7 mole%, n 13 is 0 mole%, and n 14 is about 93 mo!e% and each R 7 is a methyl group; each R is a hydrogen; n 15 = 1 ; and U is -CH 2 CH 2 CH 2 -; (2) n 12 is about 0 mole%, n 13 is 4 mole%, and n 14 is about 96 mole% and each R 7 is independently selected from the group consisting of methyl and -CH 2 CH 2 CH 2 -(O-CH 2 CH 2 -) n i 6 CH 2 -OH, wherein n 16 is 1 to 100; R 5 and R 6 together are -CH=CHCH=CH-; and L-i is -CH 2 CH 2 CH 2 -(O-CH 2 CH 2 -)ni 6 CH 2 -, wherein n 16 is 1 to 100; (3) n 12 is about 0 mole%, nι 3 is 7 mole%, and nι 4 is about 93 mole% and each R 7 is a methyl group; R 5 and R 6 together are -CH=CHCH=CH-; and Li is -CH 2 CH 2 CH 2 -; (4) n 12 is about 0 mole%, n 13 is 10 mole%, and nι 4 is about 90 mole% and each R 7 is a methyl group; R 5 and R 6 together are -CH=CHCH=CH-; and L, is -CH 2 CH 2 CH 2 -; (5) n 12 is about 0 mole%, n 13 is 4 mole%, and n 14 is about 96 mole% and each R is independently selected from the group consisting of methyl and -CH 2 CH 2 CH 2 -(O-CH 2 CH 2 -) n16 CH 2 -OH, wherein n 16 is 1 to 100; R 5 and R 6 are both H; and U is -CH 2 CH 2 CH 2 -(O-CH 2 CH 2 -) n16 CH 2 -, wherein n 16 is 1 to 100; (6) n 12 is about 0 mole%, n 13 is 7 mole%, and n 14 is about 93 mole% and each R 7 is a methyl group; R 5 and R 6 are both H; and l_ι is -CH 2 CH 2 CH 2 -; (7) n 12 is about 0 mole%, n 13 is 10 mole%, and n 14 is about 90 mole% and each R 7 is a methyl group; R 5 and R 6 are both H; and U is -CH 2 CH 2 CH 2 -; (8) n 12 is about 3 mole%, n 13 is 0 mole%, and n 1 is about 97 mole% and each R 7 is a methyl group; each R 4 is a hydrogen; n 15 = 1 ; and U is -CHzCHzCHs-NR'-CHzCHzCHz-, wherein R' is -C(O)CH 2 CH 2 CO 2 H. In a preferred embodiment, R is hydrogen. Preferably, n 15 is 1. Preferably, R 5 and R 6 are both hydrogen or together are -CH=CHCH=CH-. Preferably, R 7 is independently selected from the group consisting of methyl, phenyl, and -CH 2 CH 2 CH 2 (OCH 2 CH 2 ) n i 6 CH 2 OH, wherein n 16 is from 1 to about 100. Preferably, L^ is an alkylene group having from 1 to 12 carbon atoms or -CH 2 CH 2 CH 2 (OCH 2 CH 2 ) n17 CH 2 -, wherein n 17 is from 1 to about 100. In one embodiment, the molecular weight of the imido compound is from about 300 to about 5,000; and in another embodiment, the molecular weight of the imido compound is greater than about 5,000. In one embodiment, n 12 is from about 1 to about 99; nι 3 is from about 0 to about 99; and n 14 is from about 0 to about 99; and in another embodiment, n, 2 is from about 0 to about 99; n 13 is from about 1 to about 99; and n 1 is from about 0 to about 99. Preferably, the proteinaceous substrate is selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails. In one embodiment, the imido compound is cross-linked with a multifunctional nucleophilic agent which is preferably selected from the group consisting of 1 , 6-hexamethylenediamine, polyethyleneimines, polyalkoxides, and polythiols. In another embodiment, the water-solubilizing/dispersing moiety bears an ionic charge and is electrostatically bound to a moiety bearing the opposite charge, wherein the moiety bearing the opposite charge is preferably selected from the group consisting of antimicrobials, ultraviolet chromophores, anionic dyes, anti-oxidants, fluorescing agents, brightening agents, shine and gloss enhancers, softening agents, and conditioning agents. Preferably, the pH value of the imido compound adsorbed/absorbed on or into the proteinaceous substrate in step (b) is raised above about 7 employing a solvent in which the imido compound is substantially insoluble. More preferably, the solvent employed is selected from the group consisting of water, aqueous mixtures of C 2 -C 3 alcohols, and mixtures thereof. The present invention is also directed to a proteinaceous substrate, having an imido compound covalently bonded to a portion thereof, wherein the imido compound is derived from a residue represented by Formula (4). The present invention is also directed to imido compounds represented by Formula (4). Preferred imido compounds of Formula (4) are imido compounds wherein Y is a polymerizable saccharide-derived monomer, or an alkali, alkaline earth, or ammonium salt thereof. Other preferred imido compounds of Formula (4) are imido compounds wherein R 5 and R 6 are both hydrogen. In another preferred embodiment, the present invention is directed to a method for treating a proteinaceous substrate which comprises the steps of: (a) contacting a proteinaceous substrate with an aqueous solution of an imido compound at a pH value between about 4 and about 7 for a time sufficient to allow the imido compound to be adsorbed/absorbed on or into the proteinaceous substrate; and (b) raising the pH value of the imido compound adsorbed/absorbed on or into the proteinaceous substrate above about 7 for a time sufficient to allow the imido compound to react with the proteinaceous substrate; wherein the imido compound is selected from the group consisting of succinimide/glutimde compounds represented by Formula (5): 0=C— N— C=0 I (L- 2 — O — )ni 8 Sacch (5) maleimide compounds represented by Formula (6); 0=C— N— CO | (L- 2 — O— ) n18 Sacch (6) and copolymers of the succinimide/glutimde compounds represented by Formula (6) with the maleimide compounds represented by Formula (6); wherein R 8 is independently selected from the group consisting of hydrogen, d-C 12 branched and unbranched alkyl, aryl, aralkyl, and alkaryl; nι 5 is 1 or 2, or both; L 2 is a divalent linking group selected from the group consisting of alkylene, hydroxy substituted alkylene, oxyalkylene, polyoxyalkylene, iminoalkylene, polyiminoalkylene, phenylene, and alkylene phenylene; n 18 is 0 or 1 ; Sacch- represents a polysaccharide molecule; R 9 and Rι 0 are independently selected from the group consisting of hydrogen, Cι-C 12 branched and unbranched alkyl, aryl, aralkyl, and alkaryl, or together are -CH=CHCH=CH-; the molecular weight of the imido compound is from about 300 to about 2,000,000. In Formula (5) and (6), each R 8 is independently selected from the group consisting of hydrogen, C C 12 linear or branched alkyl, phenyl, or alkyl phenyl; n 15 = 1 or 2; L 2 is a divalent linking group selected from the group consisting of alkylene, hydroxy substituted alkylene, oxyalkylene, polyoxyalkylene, iminoalkylene, polyiminoalkylene, phenylene, and alkylene phenylene; Sacch, represents a polysaccharide molecule and is as defined in United States patent no. 4,675,394; R 9 and R 10 are independently selected from the group consisting of hydrogen, d-C 12 linear or branched alkyl, phenyl, or alkyl phenyl or R 9 and R 10 together are -CH=CHCH=CH-. When n 18 is 1 , the imido compounds represented by Formulas (5) and (6) may be prepared by reacting a polysaccharide base with a suitable derivitizing agent. Alternatively, the imido compounds may be prepared by reacting a polysaccharide to which primary amine functionality has been introduced with succinic acid, succinic anhydride, glutamic acid, glutamic anhydride, phthalic acid, phthalic anhydride, or derivatives thereof. There should be in the imido compounds, on average, at least two imido groups per polysaccharide molecule, preferably more than 60, and most preferably, greater than 350. Preferred polysaccharide bases are hydroxyethyl cellulose, guar gum, starch, and the cationic derivatives thereof. When n 18 is 0, Sacch is the residue of a polysaccharide with primary amine functionality and the imido compounds represented by Formulas (5) and (6) may be prepared by reacting a polysaccharide with primary amine functionality with succinic acid, succinic anhydride, glutamic acid, glutamic anhydride, phthalic acid, phthalic anhydride, or derivatives thereof. An example of a polysaccharide with primary amine functionality is chitosan. When the polysaccharide is starch, illustrative starch bases which may be used herein may be derived from any plant source including corn, potato, sweet potato, wheat, rice, sago, tapioca, waxy maize, sorghum, high amylose corn, or the like. Starch flours may also be used as a starch source. Also included are the conversion products derived from any of the former bases including, for example, dextrins prepared by the hydrolytic action of acid and/or heat; oxidized starches prepared by treatment with oxidants such as sodium hypochlorite; fluidity or thin-boiling starches prepared by enzyme conversion or mild acid hydrolysis; and derivatized and crosslinked starches. The starch base may be a granular starch or a gelatinized starch, i.e. non- granular starch. When the polysaccharide is gum, illustrative bases which may be used herein are polygalactomannans, which are heteropolysacchrides composed principally of long chains of 1-4, beta-D-mannopyranosyl units to which single unit side chains ofalpha-D-galactopyranosyl units are joined by 1-6 linkages and hereafter referred to as "gums". Also included are degraded gum products resulting from the hydrolytic action of acid, heat, shear, and/or enzyme; oxidized gums; and derivatized gums. The preferred gums include gum arable, as well as guar gum and locust bean gum because of their commercial availability. When the polysaccharide is cellulose, illustrative bases useful herein include cellulose and cellulose derivatives, especially water-soluble cellulose ethers such as alkyl and hydroxyalkylcelluloses, specifically methylcellulose, hydroxyethylcellulose, hydroxypropylmethyl cellulose, hydroxybutylmethylcellulose, hydroxyethylmethylcellulose, and ethylhydroxyethylcellulose . Methods for preparing the modified polysaccharide bases are well-known to those skilled in the art and are discussed in the literature. See, for example, R. L. Whistler, Methods in Carbohydrate Chemistry, Vol. IV, 1964, pp. 279-311 ; R. L. Whistler et al., Starch-Chemistry and Technology, Vol. II, 1967, pp. 293A430; R. L. Davidson and N. Sittig, Water-Soluble Resins, 2nd Ed., 1968, Chapter 2; and R. L. Davison, Handbook of Water-Soluble Gums and Resins, 1980, Chapters 3, 4, 12 and 13 directed to cellulose derivatives, Chapters 6 and 14 directed to gums, and Chapter 22 directed to starch. In a preferred imido compound, Sacch is hydroxyethyl cellulose, R 9 and R 10 together are -CH=CHCH=CH-; L 2 is -CH 2 CH(OH)CH 2 -, and n 18 is 1. The number of polyimido groups per polysaccharide molecule range from 125 to 375. Preferably, R 8 is hydrogen. Preferably, n 15 is 1. Preferably, L 2 is selected from the group consisting of alkylene, hydroxy substituted alkylene, oxyalkylene, and polyoxyalkylene. Preferably, n 18 is 1. Preferably, the Sacch- group is selected from the group consisting of starch, gum, cellulose, and chitosan, and the cationic derivatives thereof. Preferably, R 9 and Rι 0 together are -CH=CHCH=CH-. Preferably, the imido compound comprises at least two imido groups per polysaccharide molecule. In one embodiment, the molecular weight of the imido compound is from about 300 to about 5,000; in another embodiment, the molecular weight of the imido compound is greater than about 5,000. In one embodiment, the imido compound is a succinimide represented by Formula (5). In another embodiment, the imido compound is a glutimide represented by Formula (6). In yet another embodiment, the imido compound is a copolymer of the succinimide represented by Formula (5) with the glutimide represented by Formula (6). Preferably, the proteinaceous substrate is selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails. In one embodiment, the imido compound is cross-linked with a multifunctional nucleophilic agent which is preferably selected from the group consisting of 1 , 6-hexamethylenediamine, polyethyleneimines, polyalkoxides, and polythiols. In another embodiment, the water-solubilizing/dispersing moiety bears an ionic charge and is electrostatically bound to a moiety bearing the opposite charge, wherein the moiety bearing the opposite charge is preferably selected from the group consisting of antimicrobials, ultraviolet chromophores, anionic dyes, anti-oxidants, fluorescing agents, brightening agents, shine and gloss enhancers, softening agents, and conditioning agents. Preferably, the pH value of the imido compound adsorbed/absorbed on or into the proteinaceous substrate in step (b) is raised above about 7 employing a solvent in which the imido compound is substantially insoluble. More preferably, the solvent employed is selected from the group consisting of C 2 -C 3 alcohols, aqueous mixtures of C 2 -C 3 alcohols, and mixtures thereof. The present invention is also directed to a proteinaceous substrate, having an imido compound covalently bonded to a portion thereof, wherein the imido compound is derived from a residue represented by Formula (5) and (6). The present invention is also directed to imido compounds represented by Formula (5) and (6). Preferred imido compounds of Formula (5) are imido compounds wherein n 18 is 1, L 2 is -CH 2 CHOHCH 2 -, and R 9 and R 10 together are -CH=CHCH=CH-. Other preferred imido compounds of Formula (5) are imido compounds wherein wherein n 18 is 1 , L 2 is -CH 2 CHOHCH 2 -, n 15 is 1 , and R 8 is hydrogen. Use of the Water-soluble/dispersible Polyimides Compounds for Modifying Hair Hair may be reacted with a water-soluble/dispersible polyimide in order to impart a permanent benefit as set out below. Internal Modification of Hair with Water-soluble/dispersible Polyimides Reparation of Chemically Damaged Hair Perming and bleaching of hair results in cleavage of the sulfur-sulfur cross-linkages connecting the protein chains resulting in a weakening of the hair. In addition, the perming formulations are generally very alkaline and may also cleave some amide linkages in the protein chains resulting in a further weakening of the hair. This effect is especially pronounced when the hair is wet. This chemically damaged hair can be repaired by imparting to the hair additional cross-linkages through reaction of a multifunctional acylating agent of the present invention with the various nucleophilic groups present in the hair. Nucleophilic moieties, such as the free amino groups present in the basic amino acids lysine, arginine, or histidine (which are naturally present in hair), terminal amino groups resulting from cleavage of amide bonds, sulfhydryl groups from the cleavage of cystine, and phenolic groups present in aromatic amino acids may all be employed in the acylation reaction. Post Cross-linking to Further Repair Chemically Damaged Hair In addition to cross-linking the protein chains in the hair with the polyimide acylating agents set out above, multifunctional nucleophilic agents such as 1 , 6-hexamethylenediamine, low-molecular weight polyethyleneimines, polyalkoxides, and polythiols, can be added to the hair in order to react with the acylating agent and to promote the development of an internal polymeric network which can further strengthen the hair. Damaged hair may be treated with water-soluble/dispersible polyimides of various molecular weights ranging from 1000 to 4500, and preferably exhibiting a net neutral charge (due to the solubilizing group). Non-Degradative Permanent Waving or Set Perming or set can be imparted to hair without cleaving the disulfide bonds and without weakening of the hair by using a low molecular weight neutral charged water-soluble/dispersible polyimide to form new chemical cross-links between the polyimide and various nucleophiles (i.e., amino groups in lysine, terminal amino groups, phenoxide groups, etc), which exist within the hair fiber. Alternatively, additional cross-links can be formed to develop an internal polymeric structure by first allowing the polyimide to penetrate the hair and then following with the addition of multifunctional nucleophilic agents such as polyamines, polythiols, and the like. In one preferred embodiment, a water-soluble/dispersible polyimide of the present invention, having a molecular weight between approximately 300 and 5000, is applied to hair (which has been place in a curled array) at a pH between about 4 and about 7 and allowed to penetrate the hair. After a time sufficient to penetrate the hair, the hair is treated with a buffer solution having a pH 8- 10 and a temperature between 20-55 °C. In a more preferred embodiment, a water-soluble/dispersible polyimide, which is neutral in charge, and having a molecular weight between approximately 1000 and 4000 is used as above at a temperature between 30 and 55 °C. In a most preferred embodiment, a water-soluble/dispersible polyimide, which is neutral in charge, and having a molecular weight between approximately 2000 and 3000 is used as above at a temperature between 35 and 45 °C. External Modification of Hair with Water-soluble/dispersible Polyimides Reaction of a water-soluble/dispersible polyimide of the present invention can be confined to the exterior of the hair generally by controlling the molecular weight and the charge of the polyimide. A water- soluble/dispersible polysuccinimide of molecular weight > 5000 can be applied to the hair at the appropriate pH, whereupon the pH is elevated, and the hair is heated to effect the covalent linkage with the polymer. The Primer Approach Intact hair is normally quite hydrophobic. However reaction of hair with a water-soluble/dispersible polyimide, especially one which is highly charged or in which the polymer will exhibit a charge after hydrolysis of residual imide moieties, will result in hair which has a much more hydrophilic surface. Hair normally has an overall negative charge because of the presence of high levels of aspartic acid and glutamic acid. Reaction of hair with a polyimide made water-soluble/dispersible by the presence of a large number of quaternary groups will impart an overall positive charge on the surface of the hair. An advantage of covalently binding a water-soluble/dispersible polyimide carrying a high positive charge to hair is that the positive charges on the polymer become a magnet for anionic species. By priming the hair with a positively charged polymer, such as the structure shown below, one can attract and bind anionic chemical moieties: The primer approach may be used to impart a wide variety of beneficial properties to the hair by exposing the cationically modified hair to the appropriate anionic group (typically delivered from a shampoo, lotion, spray etc.), which would then become electrostatically bound to the polymer. The following are potential uses of this approach (a) Antimicrobials having an anionic charge, e.g., Triclosan, a phenolic can be bound to the surface of hair providing protection to the hair and the scalp from attack by microrganisms. (b) UV chromophores, having anionic charge such as methoxycinnamic acid or para-aminobenzoic acid, can be bound to hair providing protection to the hair from UV light. (c) Anionic dyes, such as tartrazine, can be bound to hair to provide color. (d) Anti-oxidants, such as sodium ascorbate, can be bound to hair providing protection from oxidation to the hair and to its melanin. (e) Fluorescing agents. (f) Brightening agents. (g) Shine and gloss enhancers, (h) Softening agents, (i) Conditioning agents. Use of the Primer Approach to Impart Conditioning to Hair Damaged hair, whether it is chemically damaged from a bleaching or perming process, from weathering, or from physical damage such as teasing or ratting, typically has very poor combing properties. A number of positively charged water-soluble/dispersible polyimides may be reacted onto the surface of damaged hair to attract conditioners. Ease of wet combing is viewed as an indication of "conditioned hair". Results from experiments (described below) testing this idea clearly show that the highly positively charged polyimide having been covalently reacted to the hair, is then able to electrostatically bind the sodium lauryl sulfate, in which it is subsequently washed, to itself and in the process to the surface of the hair where it serves to lubricate the hair and to provide improved wet combing. Use of the Water-soluble/dispersible Polyimido compounds for Modifying Skin In principal, the same approach used to achieve external modification of hair can be used to modify the surface of the skin, i.e., either high molecular weight >5000 or positively charged water-soluble/dispersible polyimides would be used. The polyimide would be applied to the skin at a pH between 4 and 7, whereupon the pH of the skin would then be raised with a buffer to above about 7 and the temperature raised to between 35 and 45 °C. Use of the Water-soluble/dispersible Polyimido Compounds in Skin Care The water-soluble/dispersible polyimido compounds of the present invention may be employed to protect skin from alkaline attack, such as from dishwashing liquids. A water-soluble/dispersible polyimido compound, such as the structure set out below or others in which the the solubilizing groups are present at a minimum concentration so that hydrolysis of the residual succinimide moieties would result in the maximum amount of aspartate residues present, may be employed to bind to the skin and exhibit maximum buffer capacity. Use of the Primer Approach to Provide Benefit to Skin As set out above for hair, a water-soluble/dispersible polyimide containing high levels of cationicity, such as is shown below, may be covalently bound to skin. By using the primer approach, a wide variety of anionic species may be bound to the skin to provide numerous benefits. Anti-microbials and anti- fungals containing anionic groups would electrostatically bind to the positively charged primer and gradually release to the skin thereby giving longer lasting protection from various microorganisms. Ultra-violet chromophores, such as salts of methoxycinnamic acid and n, n- dimethylamino p-benzoic acid would bind thereby giving increased sun protection. Anionic Dyes could be applied to the skin treated with the positively charged polyimide thus providing body art having semi-permanence. Anionic conditioning agents, e.g., anionic silicones or salts of fatty acids, or sulfated hydrocarbons could be electrostatically bound to impart to the skin a conditioned feel. Reparative or rejuvenative agents such as salts of glycolic acid or hyaluronic acid could be bound to the skin and then gradually released over time. The precise formulation of the therapeutic composition will vary depending upon the specific end use. Other ingredients may also be incorporated into the therapeutic compositions as dictated by the nature of the desired composition as well known by those having ordinary skill in the art. The therapeutic compositions are readily prepared using methods generally known in the therapeutic arts. Examples of additives traditionally used in therapeutics include emollients, rheology modifiers, fillers, humectants, thickeners, preservatives, dyes, and pigments, which may be employed in conventional amounts. Illustrative examples of emollients include isopropyl myristate, isopropyl palmitate, isopropyl laurate, isopropyl stearate, glyceryl stearate, dioctyl adipate, cetyl oleate, PEG-7 glyceryl cocoate, PEG- 15 glyceryl trioleate, polyglyceryl-3 dicaprate, polyglyceryl-3 laurate, cyclomethicone, and PPG-1-ceteth-1. Emollients are generally used in amounts from 2 to 30 parts by weight, preferably 3 to 20 parts. Illustrative examples of thickeners include carbomer, carrageenan, salts of alginic acid, derivatives of chitosan, bentonite, casein, fumed silica, guar gum, gum tragacanth, hydroxy-ethylcellulose, locust bean gum, methylcellulose, polyacrylic acid salts (ammonium, potassium, sodium), polyvinyl alcohol, sodium carboxymethyl cellulose, and starches. When present, thickeners will be used in amounts up to about 10 parts by weight. Illustrative examples of fillers include bentonites, calcium carbonate, calcium silicate, clay, mica, nut shell flours, silica, talc, uncooked starches, and wood flour. When present, fillers will be used in amounts up to about 20 parts by weight. Illustrative examples of humectants include glucamine, PCA, glucuronic acid, polyglycerin-4, diethylene glycol, glycerine, hexylene glycol, propylene glycol, sorbitol, sucrose, and urea. When present, humectants will be used in amounts up to about 10 parts by weight. Surfactants are often employed in therapeutic compositions to increase the penetrating effects of the therapeutic. The surfactants may be one or more of anionic, cationic, amphoteric or nonionic surface-active compounds. Suitable anionic emulsifiers are, for example, alkyl sulfonates, alkylaryl sulfonates, alkyl sulfates, sulfates of hydroxylalkanols, alkyl and alkylaryl disulfonates, sulfonated fatty acids, sulfates and phosphates of polyethyoxylated alkanols and alkylphenols, as well as esters of sulfosuccinic acid. Suitable cationic emulsifiers are, for example, alkyl quaternary ammonium salts, and alkyl quaternary phosphonium salts. One type of suitable non-ionic emulsifier is the addition product of 5 to 50 moles of ethylene oxide adducted to straight-chain and branched-chain alkanols with 6 to 22 carbon atoms, or to alkylphenols. higher fatty acids, higher fatty acid amines, or primary and secondary higher alkyl amines. Other suitable nonionic emulsifiers are one or more block copolymers of propylene oxide with ethylene oxide. Preferred surfactants include fiuorinated alkyl amphoterics or sodium dioctylsulfosuccinate. When present, the surfactant will be used in amounts of about 0.05 to 5.0 parts by weight. One skilled in the art, having the knowledge of the present specification, will readily ascertain those applications in which the use of the inventive therapeutic compositions would be advantageous. Any conventional method of applying the therapeutics to the particular substrates may be employed. These methods are well known in the field of therapeutics. Throughout this application, various publications have been referenced. The disclosures in these publications are incorporated herein by reference in order to describe more fully the state of the art. Throughout this disclosure, applicant will suggest various theories or mechanisms by which applicant believe the components in the therapeutic compositions function together in an unexpected manner to provide unique treatments for proteinaceous substrates such as skin and hair. While applicant may offer various mechanisms to explain the present invention, applicant does not wish to be bound by theory. These theories are suggested to better understand the present invention but are not intended to limit the effective scope of the claims. The present invention is further illustrated by the following examples which are presented for purposes of demonstrating, but not limiting, the preparation of the compounds and compositions of this invention. Examples Background While the data in these experiments demonstrates the applicability of the present invention for modifying hair, other nucleophilic sites on other proteinaceous substrates may also undergo the same acylation chemistry. Thus for example, hair, wool, skin, leather, silk, fur, felt, and nails, which all have nucleophilic sites available either along the polypeptide backbone or on the amino terminus, would be expected to react with the water- soluble/dipersible reactive succinimide functionality. The relative concentrations of the basic amino acids (lysine, histidine, and arginine) those most likely to undergo acylation) found in hair, wool, silk, leather, skin, and nails, are set out below. Amino Acid Hair Wool Silk Leather Skin Nails Lysine 2.6-3.1 2.7 0.7 3.4-5.6 5.4-6.3 3.1 Histidine 0.8-1.1 1.1 0.4 0.7 2.2-2.4 1.0 Arginine 8.8-9.6 10.2 1.1 8.0-8.6 5.2-7.1 6.4 Preparation of a Neutral Water-soluble/dispersible Poly(succinimide) To a 500 mL 3- or 4-necked round bottom flask equipped with an overhead mechanical stirrer, oil bath with temperature controller, nitrogen line and reflux condenser, was added DMSO. Twenty grams of poly(succinimide) (weight average molecular weight = 4,500) was dried at 120 °C for at least 1 hour, then added to the DMSO to achieve a solution of 20% solids. The poly(succinimide) solution was stirred and heated until all polymer dissolved (usually around 50-55 °C), and 6.22 grams ethanolamine was added slowly to the reaction. The reaction was maintained at 60 °C with stirring, under nitrogen, overnight, and periodically titrated as above for free amine concentration. After completion, the reaction was allowed to cool to room temperature, and transferred to a separatory funnel. The reaction mixture was slowly added dropwise to a large excess of ethyl acetate with vigorous mechanical stirring. The viscous precipitate was suspended in acetone, stirred and broken up by hand. A mechanical homogenizer was used to reduce the particle size of the product, which allowed better extraction of the DMSO from the polymer in acetone. The powdered and granular products were isolated by vacuum filtration and dried overnight at 60 °C. The polymers were then ground using a mortar and pestle, resuspended in acetone, homogenized (if the particle size was still large), filtered and dried again. Preparation of a Cationic Water-soluble/dispersible Poly(succinimide) The general synthetic route for preparing a water-soluble/dispersible poly(succinimide) is described below. To a 500 mL 3- or 4-necked round bottom flask equipped with an overhead mechanical stirrer, oil bath with temperature controller, nitrogen line and reflux condenser, was added DMSO. Poly(succinimide) was dried at 120 °C for at least 1 hour, then added to the DMSO to achieve a solution of 20% solids. The poly(succinimide) solution was stirred and heated until all polymer dissolved (usually around 50-55 °C), and dimethyl amino propyl amine was added slowly to the reaction. The reaction was maintained at 60 °C with stirring, under nitrogen, overnight, and periodically titrated as above for free amine concentration. After completion, the reaction was allowed to cool to room temperature, and transferred to a pressure reactor. The reaction mixture was exposed to CH 3 CI gas. The pressure in the reactor was measured and the reaction was allowed to proceed until the pressure no longer changes. The reactor was depressurized and the resulting solution was transferred to a separatory funnel. The reaction mixture was slowly added dropwise to a large excess of ethyl acetate with vigorous mechanical stirring. The viscous precipitate was suspended in acetone, stirred and broken up by hand. A mechanical homogenizer was used to reduce the particle size of the product, which allowed better extraction of the DMSO from the polymer in acetone. The powdered and granular products were isolated by vacuum filtration and dried overnight at 60 °C. The polymers were then ground using a mortar and pestle, resuspended in acetone, homogenized (if the particle size was still large), filtered and dried again. Rate of Reaction of Water-soluble/dispersible Polysuccinimides with Nucleophilic Agents Versus Hydrolysis This example describes the reaction of a water-soluble/dispersible polysuccinimide with an organic amine in water to show that polysuccinimide can be made water-soluble/dispersible and that its rate of reaction with nucleophilic agents (an amine in this case) in aqueous media is competitive with that of the hydroysis reaction. The result is a level of acylating ability that allows modification of substrates in aqueous media. To prove that polysuccinimide (PSI) derivatives can react with amines in water to form covalent amide linkages, a study was conducted to determine reaction rates and rates of amidation versus hydrolysis. In the first series of experiments, the rate of hydrolysis (Scheme 1) of polysuccinimide derivatives at various pHs was measured by applying a pseudo-first order kinetics analysis (Scheme 1). The rate and extent of amidation versus hydrolysis was then measured by treating the polysuccinimide derivative with an amine in water (Scheme 2). Scheme 1 Simple Hydrolysis Fp38-40 Scheme 2 hydrolysis am at on Amberlite lR 120 resin Amidation versus Hydrolysis In the above studies, a polysuccinimide derivative that has been functionalized with 50 mol% of ethanolamine was used as a model material. The derivative is water-soluble/dispersible and has a simple, assignable NMR spectrum. For the amidation versus hydrolysis experiments, NMR was used to determine the ratio of amidation (value of "y" in Scheme 2) to hydrolysis (value of "x" in Scheme 2). The amine salt resulting from the hydrolysis reaction was removed via ion exchange, before NMR analysis was performed Hydrolysis of Reactive Derivatives Procedure Make a 1 % aqueous solution of PSI derivative. Hold pH constant, using 1N sodium hydroxide, at desired pH using pH STAT method on Brinkman autotitrator. Monitor sodium hydroxide uptake. From the amount of sodium hydroxide used to open the succinimide rings, the rate of hydrolysis can be determined. Determine the amount of sodium hydroxide needed to hydrolyze the succinimide rings, and the rate at which hydrolysis occurs. Pseudo-First Order Kinetic Analysis Results PH Time to 25% Hydrolysis Time to 50% Hydrolysis 5.00 No hydrolysis occurred after 3 days — 6.00 36.7 hours — 7.00 14.4 hours — 8.00 67 minutes 7.8 hours 9.00 9.5 minutes 52.5 minutes 10.00 2.25 minutes 11.25 minutes 11.00 2.0 minutes 4.0 minutes s set out above, the reaction takes place very quickly at high pH. Results: Expt.# pH PSI Actives (%) Equivalents # Amidations vs. of Butylamine # Hydrolysis 1 5.00** 5% 3 1 :14 2 9.00 0.9% 3 1 :17 3 10.00 1% 3 1 :94 4 10.00 10% 1 1 :7 5 10.00 10% 3 1 :7 6 11.00 1% 3 1 :24 7 11.00 10% 3 1 :1 to 1:6 8 11.45 4.5% 3 1 :1 to 1:3 General Conclusions At pH 10-11 , there is significant amidation which competes with hydrolysis. In fact, under certain conditions, 1 amidation event can occur for every 1 hydrolysis, that is, x=0.25 and y=0.25 in Scheme 2. Time Experiment Procedure: The general procedure is the same as that used for the Amidation versus Hydrolysis experiment except that samples are taken at designated times. Each sample is treated with two or more equivalents of ion-exchange resin. The resin is filtered off and the material is freeze-dried. An NMR is then taken of the product. Results and Conclusions The experiment was run at pH=10, 10% PSI actives, and 1 equivalent of butylamine and at pH=11 , 10% PSI actives, and 3 equivalents of butylamine. At pH 10, the reaction is over after about thirty minutes and at pH 11 , the reaction is over in about five minutes. Thus, at high pH reaction of the polysuccinimide (either hydrolysis or amidation) takes place extremely quickly. Overall Conclusions The above results demonstrate that under homogeneous conditions, amidation competes very favorably with hydrolysis at high pH, and that it is possible to form covalent amide linkages under aqueous conditions. Modification of Hair With a Water-soluble/dispersible Polysuccinimide- Proof of Reaction One strategy to demonstrating covalent linkage between water- soluble/dispersible reactive derivative and proteinaceous substrate is to treat the proteinaceous substrate with polymer and measure the permanence of a change in the surface properties as a function of washing the surface with a good solvent for the polymer. The concept is that lack of covalent linkage allows polymer to be removed from the surface due to solubility in the solvent or conversely; that the presence of covalent linkage maintains the permanence of the effect as a function of successive washings. A measurable property of the surface of hair is its ability to be wet by water. Instrumentation (KRUSS K14 Tensiometer) allows measurement of the force necessary to immerse a single fiber of hair into water. In this manner a relation between that force (Wetting Force) and contact angle between the water and the hair fiber can be used to detect changes which have been made to the surface of the hair. The following expression describes the relation between the Wetting Force (Fw) and the contact angle (φ) of a solid cylinder of perimeter, p being immersed into a liquid with surface tension γ; Fw = p γ cos φ. It is well known that European, brown, virgin hair has, on average, a circular cross-section with perimeter 0.221mm, therefore allowing approximation to a solid cylinder. It is furthermore well known that the surface of European, brown, virgin, hair is hydrophobic. This means that the contact angle of water on the surface of hair is greater than or equal to 90°. This then corresponds to a near zero or negative wetting force (as φ → 90°, cos φ → 0, as cos φ → O. Fw → 0). Addition of a layer of water-soluble/dispersible poly(succinimide), bound to the surface of European, brown, virgin, hair will decrease the hydrophobicity of hair due to the addition of functional groups such as aspartic acid and hydroxyethyl aspartamide. A decrease in the hydrophobicity of hair will allow water to wet the surface of hair better. Subsequently, the contact angle φ will be reduced. A reduction in contact angle corresponds to an increase in wetting force. Subsequently, the contact angle φ will be reduced. A reduction in contact angle corresponds to an increase in wetting force. The change in the hydrophobicity of virgin hair due to the presence of polar and hydrogen bonding units of the reactive polymer can be used as a measure of the presence of the reactive polymer on hair. Measurement of this property as a function of washes in a known good solvent (detergent solution) for the polymer will allow conclusions about the permanence of the effect. Hair treatment with water-soluble/dispersible poly(succinimide) of polysuccinimide can generally be viewed as having two steps. In the first step, hair is treated with reactive derivative in order to deposit the derivative onto or into the hair. In the second step, hair treated with reactive derivative is exposed to conditions that favor the deprotonation of nucleophilic groups on the surface of hair such as amine and sulfhydryl that are expected to be present due to the amino acid composition of hair keratin. These nucleophilic species are then capable of reacting with succinimide moities on the polymer and covalently linking the surface of hair to the polymer. The following diagram schematically depicts the process. Plot l Schematic of Hair Treatment with Water-soluble Reactive Derivative of Polysuccinimide The following experimental design employs the wetting force measurement strategy and comparative experiments to demonstrate the concept of covalent linkage of the polymer to hair. In the first step, the hair fibers (in the form of a 0.5 gram bundle of hair of approximately 12 inch in length) were rinsed with chloroform followed by methanol then chloroform. This solvent rinse is designed to remove polar and non-polar impurities. Following this rinse, the hair was immersed in a pH=7 buffer solution (0.2N Na 2 HPθ 4 /0.1N Citric Acid). The hair was then rinsed in deionized water and dried. Tresses 11A and 11B were then immersed into a 10% (mass) solution of water-soluble/dispersible poly(succinimide) (50% (mole) imide/50%(mole) ethanolamine) with weight average molecular weight of 4500. Tress 11C was treated with a hydrolyzed (non-reactive) version of the same polysuccinimide. Tress 11 , 11 B, and 11 C were then immersed into 30mL of pH =10 buffer solution (0.02N sodium carbonate/sodium bicarbonate) and heated to 50°C for 60 minutes. Tress 11A was immersed into 30mL of deionized water and heated to 50°C for 60 minutes. Following these treatments, the hair was washed with water five times followed by 20 washes in a 3%(mass) solution of triethanolamine lauryl sulfate. The hair tress was immersed in the washing solution and excess solution was squeezed out after each immersion. Several hair fibers were randomly selected for wetting force testing. Tress 11 is a control tress to determine the effect of the process conditions on the surface of hair. Tress 11A is treated in a manner to determine if permanent changes in the surface properties of hair are observed with treatment conditions that do not favor reaction between the polymer and hair. Tress 11B is treated in a manner to favor the reaction. Tress 11 C is treated with a non-reactive version of the polysuccinimide used in 11A and 11B. The wetting force of the treated hair did not vary with immersion depth. Therefore, the wetting force results are presented as the average value over the immersion depth. Table 1 tabulates the results after 20 detergent washes. Table 1. Average Wetting Force After 20 Detergent Washes The results of the wetting force measurements clearly show that only tress 11 B demonstrates a permanent increase in wetting force after detergent washes. The fact that tress 11 did not display an increase in wetting force indicates the effect was not caused by process conditions. The fact that tress 11C did not display an increase in wetting force indicates the effect was not caused by non-covalent binding between hair and polymer. The fact that tress 11B, which was not exposed to conditions favoring acylation did not display a permanent increase in wetting force and that 11A did (see favorable reactions) suggests that covalent linkage occurs between the polymer and hair. Internal Modification of Damaged Hair Using Water-soluble/dispersible Polysuccinimides Hair that has been bleached and/or permed is chemically damaged. The chemical damage is the result of cleavage of the sulfur-sulfur cross-linkages and alkaline cleavage of amide linkages in the protein chains of the hair, which frequently fail to reform completely. As a result, hair is weakened. The strength or weakness of the hair can be measured as a function of its ability to withstand stretching to an additional 20% of its original length, i.e. damaged hair is relatively easy to extend 20% whereas intact hair requires much more work to extend an additional 20%. In this experiment, the extent to which the strength of chemically damaged (bleach/perm) hair can be rebuilt was measured. Hair strength was measured by measuring the work required to extend the hair an additional 20% of its length. Four polymers were prepared with the compositions set out below. The molecular weights of the starting poly(succinimide) were 1100, 2500, and 4500. Each molecular weight was derivatized with 50 mole% ethanolamine. Additionally, the Mw=2500 starting poly(succinimide) was derivatized with 50 mole% DMAPA (Cl-quat). There were three treatment conditions studied: 1) 60 minute soak of hair in polymer solution followed by a soak in a pH=10 buffer solution, at 45°C, for 30 minutes, 2) 60 minute soak of bleached, permed hair in polymer solution followed by soak in a solution of poly(ethyleneimine) Mw = 750,000 (5% by mass, pH=10.8), at 45°C, 30 minutes, 3) 60 minute soak of hair in polymer solution followed by a soak in a solution of hexamethylene diamine, at 45°C, for 30 minutes. Additionally, three concentrations of hexamethylene diamine were tested: 0.22%, 2.2%, and 4.4% (mass%, pH=10-11.5). Control experiments were performed for each different process. These control experiments consisted of substitution of the polymer treatment with a 60 minute soak in pH=5.4 buffer (pH of water- soluble/dispersible-reactive derivative) followed by the identical treatment as described in 1), 2), and 3) above. Table 1 Composition of Reparative Polymers Results: Table 1 defines the legend for the figure, tabulates the data, and the 20% index. The 20% index is defined as the ratio of the work to 20% extension after treatment to the work to 20% extension before treatment. The work to 20% extension before treatment is taken as the value for bleach/perm hair. Table 2 tabulates the data and the 20% index Table 2 Treatment Average Work to 20% Standard Deviation 20% Index Extension (Gm cm) (Gm cm) A Virgin Brown Hair 95.9 B Bleached/Permed Hair 42.3 - 1 C B+Buffer Process Control 42.6 26.7 1.007 D B+Mw=1100 Neutral 64.7 29.2 1.529 E B+Mw=2500 Neutral 58.2 29 1.375 F B+Mw=2500 Cationic 45.4 23.6 1.075 G B+Mw=4500 Neutral 41.7 24.8 0.9858 Comparison of A and B demonstrates the well-known degradation of tensile properties of hair upon chemical processing. Comparison of B and C demonstrates that the buffer treatment process has no impact on the tensile properties of damaged hair. Comparison between D, E, and G show the relation between performance and molecular weight. Comparisons of E and F show the impact of a cationic charge. The neutral material (E) shows a 20% Index significantly > 1 while the cationic one (F) shows a 20% index only slightly >1. These data allow the following conclusions. In order to be effective in improving the strength of damaged hair, the polymers should have a molecular weight < 4500. Optimally the polymer should have a molecular weight in the range 1100-2500. The polymer should not be cationic in charge. Table 3 tabulates the data, and the 20% index. Table 3 Treatment Average Work to 20% Standard Deviation 20% Index Extension (Gm cm) (Gm cm) A Virgin Brown Hair 95.9 — — B Bleached/Permed Hair 42.3 - 1 H PEI Control 69.5 33 1.64 1 Mw = 2500 Neutral PEI 69.4 34.8 1.64 J HMD Control 53.7 25.2 1.26 K Mw = 2500 Neutral mid HMD 95.8 41.4 2.26 L Mw = 1100 Neutral mid HMD 89.7 44 2.12 M Mw = 4500 Neutral mid HMD 52.7 42 1.24 N Mw = 2500 Neutral low HMD 58.9 32 1.39 O Mw = 2500 Neutral High HMD 68.4 20 1.61 Comparison between B and H demonstrates that control treatment with poly(ethyleneimine) Mw = 750000 shows a positive impact on the work to 20% extension. Comparison between H and I shows no benefit to the addition of the water-soluble/dispersible reactive derivative. Comparison between B and J demonstrates that the control treatment with hexamethylene diamine shows a positive impact on the work to 20% extension. However addition of the water-soluble/dispersible reactive derivative of poly(succinimide) shows a dramatic improvement over this control. Comparison between K, L, and M again demonstrates the performance as a function of molecular weight. Comparisons between K, N, and O demonstrate that there is an optimum concentration of hexamethylene diamine. These data allow the following conclusions. There is a benefit in a reaction step employing a multifunctional amine. The multifunctional amine should be low in molecular weight. There is an optimum concentration of the multifunctional amine. The polymer should have molecular weight < 4500. Optimally the polymer should have a molecular weight in the range 1100- 2500. The Use of the Primer Approach to Impart Conditioning to Hair It is well known that chemically processed hair (bleach/perm) suffers from poor wet combability. Poor wet combability results in an unpleasant combing experience and often times to hair breakage. Combing aids historically employed cationic surfactants and cationic polymers. The aids are substantive to hair and provide an improvement in wet combability. Currently hair care products employing these ingredients suffer from build up problems upon repeated use that result in undesirable aesthetics. Furthermore, the conditioning afforded by these products is only temporary. In the example below, a more durable approach to conditioning hair that affords controlled deposition of the conditioning aid (and thus eliminates the potential for build-up) is described. Four polymers were applied to hair. Table 4 describes the composition of these polymers. Polymers #1 and #2 are water soluble/dispersible poly(succinimide)s having varying levels of cationic substitution (tri-methyl amino propyl amine). Polymer #3 is a non-reactive version of polymer #1 and has no group capable of covalent linkage to hair. Polymer #4 is a cationic hydroxyethyl cellulose derivative (Polyquaternium 10) used as a wet comb aid. Table 4 Polymers Used in Wet Combability Study Ease of wet combing is viewed as an indication of conditioned hair. The experiment was designed to determine the wet combability of hair after treatment with the polymer as a function of 10% sodium lauryl sulfate (aq) solution. The % original work of wet comb is calculated by dividing the work of wet comb after polymer treatment and washing by the work of wet comb before polymer treatment and multiplying the result by 100. Hence, a lower % indicates an improvement in wet combability. Table 5 tabulates the results. Table 5 Tabulated Wet Combability Results # of Washes #Control #1 #2 #3 #4 0 100 100 100 100 100 1 — — — 30 65 4 89 46 40 — — 5 — — — 60 110 9 ~ — — 85 112 10 — 59 42 — — 15 102 38 29 — — 20 84 44 42 „-. __ The experiment was designed to determine the wet compatibility of hair after treatment with these polymers in #4 as a function of washing in a 10% sodium lauryl sulfate solution. A plot is prepared of % of original work of wet comb versus the number of washes in 10% SLS solution. The % original work of wet comb is calculated by dividing the work of wet comb after polymer treatment and washing to the work of wet comb before polymer treatment and multiplying the result by 100. Hence a lower % demonstrates a reduction in wet combability. The control result is the result of bleach/perm damaged hair which was subjected to acylation conditions (e.g., time, temperature, pH, washes, etc.) but which never came in contact with a water-soluble reactive derivative. The control shows no significant reduction in over 20 washes. Polyquaternium 10 (cationic hydroxyethyl cellulose) is a polymer currently used as a hair conditioning polymer. It is cationic and thus substantive to hair, however, it has no group capable of forming a covalent bond to hair. The results for Polyquaternium 10 shows an initial significant reduction in wet combability followed by a steady 'give back' to the level of the control after 10 washes. The results for polymer #3 show a similar trend. Polymer #3 is also cationic and thus substantive to hair and again it has no group capable of binding to hair. It exhibits similar behavior to Polyquaternium 10 in that it shows an initial reduction in wet combability followed by a 'give back' after a few washes. Polymers #1 and #2 show similar behavior in that they show a reduction in wet combability and maintain that reduction as a function of washing as long as twenty washes. Both polymers display nearly identical performance. The results demonstrate the following. First, polymers without covalent binding groups give a transient improvement in wet combability. This is most likely because the ionic bond between anionic hair and cationic polymer are solvent sensitive and can be affected by aqueous surfactant. Second, binding a cationic polymer to hair and using it to attract anionic surfactant gives significant improvements in wet combability that is more durable than traditional approaches. Furthermore, because the cationic groups of the polymer are the only groups capable of binding the active species (anionic surfactant), the deposition of the active is controlled and there is no opportunity for build up. The Selection of Suitable pH Adjusting Solvent The following examples set out to demonstrate the selection of suitable pH adjusting solvents and the results of modification of proteinaceous substrate. A polymer having the general structure set out below was employed:. wherein x, y, and z are approximately 20 (mole) %, 50%, and 30% and the weight average molecular weight of the starting poly(succinimide) is approximately 30,000. The solubility parameter of this polyimido compound was calculated as follows: The solubility parameter of water was: 35.8 MPa 1/ 2 The solubility parameter 2-propanol was: 23.5 MPa 1/ 2 . Solutions of 0.025M sodium bicarbonate/sodium carbonate (aq), and aqueous 2-propanol were prepared. The measured pH of the aqueous solutions was 10+/-0.2. Solubility of the polymer was tested by addition of the polyimido compound to the solutions at various concentrations. The Table below lists the compositions of the mixtures tested, their calculated solubility parameters, and the solubility of the polymer in the solvent. Examples These examples illustrate a comparison of the method of the present invention for treating a proteinaceous substrate with an aqueous solution/dispersion of an imido or polyimido compound, wherein the imido or polyimido is soluble or dispersible in the solvent (control method) and wherein the imido or polyimido is substantially insoluble in the solvent (improved method). In these examples, a dye containing polymer with the general structure given below, capable of coloring hair in a fashion that is permanent against washout when applied to hair using the control method, where x, y, and z are approximately 20 (mole) %, 50%, and 30% and the weight average molecular weight of the starting poly(succinimide) is approximately 30,000 was applied to hair using both the control method and the improved method. Experiment (Control Method) A 10% (mass) solution of the polymer was dissolved into water. Three milliliters of the solution were applied to a ~1.5 gram/8 inch tress of natural blonde hair. The solution was massaged into the hair fibers by mechanical rubbing. The treated tress was allowed to stand at room temperature for 20 minutes. Three milliliters of a buffered solution (0.025 molal (aq) /sodium carbonate/sodium bicarbonate, pH = 10) were massaged into the hair tress and hung in a 45°C oven for 40 minutes. The polymer displays 20%-50% solubility in the solution of sodium carbonate/sodium bicarbonate. Experiment (Improved Method) A 10% (mass) solution of the polymer was dissolved into water. Three milliliters of the solution were applied to -1.5 gram/8 inch tress of natural blonde hair. The solution was massaged into the hair fibers by mechanical rubbing. The treated tress was allowed to stand at room temperature for 20 minutes. Three milliliters of a solution of the following composition was applied to the hair: 30% (mass) (0.025 molal (aq) /sodium carbonate/sodium bicarbonate), 70% (mass) isopropyl alcohol. The pH of this solution was 10. The polymer displays approximately less than 1% solubility in this pH adjusting solution. The hair treated according to the control method has a peach color that is persistent against washout. The hair treated according to the improved method has a red color that is persistent against washout. The red color achieved in the improved method is indicative of more resident polymer than the control method. Furthermore, the color intensity achieved using the improved method is practically more useful than the intensity achieved with the control method. Examples The following examples demonstrate the preparation of maleimide copolymers useful for the modification of proteinaceous substrate. Preparation of poly(n-trimethyl amino propyl chloride maleimide-co- styrene) (maleimide-co-styrene no. 1) Forty grams of styrene/N-dimethylaminopropylmaleimide copolymer (SMA 2000) was dissolved in 160 ml dimethylformamide in a 600ml beaker. The solution was transferred to the Parr Hydrogenation Apparatus, which is connected with a methyl chloride gas cylinder. Methyl chloride was then charged to the reaction vessel. The pressure gauge connected to the reaction vessel indicated the consumption of methyl chloride. The reaction vessel was recharged with methyl chloride repeatedly until the pressure of the reaction vessel stayed at constant pressure, which is an indication of the completion of methylation. The reaction mixture was poured into 600ml acetone and the product precipitated out. The product was then resuspended several times in acetone to remove the residual DMF and dried in vacuum oven at 60°C. Proton and 13 C NMR revealed that the ratio of imide/styrene is about 2/3 and the tertiary amine was fully methylated. This cationic styrene-maleimide copolymer is referred to as (maleimide-co-styrene no. 1) in the following hair tests. Hydrolysis of cationic styrene-maleimide copolymer (cationic styrene- maleimide no. 2) Ten grams of the above cationic styrene-maleimide copolymer were dissolved in 100ml water in a three-neck round-bottom flask. The flask was heated to 85-90°C with oil bath. The pH of the reaction was controlled at 11.5 by a pH-stat with 3N NaOH solution. The hydrolysis was continued until the reaction stopped consuming the base. FTIR was used to confirm the completion of the hydrolysis of the imide groups. This hydrolyzed product is referred to as cationic styrene-maleimide no. 2. Polymerization of MAPTAC/n-Ethyl maleimide (MAPTAC/n-Ethyl maleimide no. 3) A 4-neck, 250ml round bottom flask was equipped with a condenser, N 2 inlet, overhead stirrer, thermometer, and two slow addition funnels. N-ethyl maleimide (10g, 0.08 moles) and MAPTAC (35.28g, 50%, 0.08 mole) were dissolved in 2-propanol and charged into one of the two additional funnel. 2,2'-azobisisobutyronitrile (AIBN, 0.4g) was also dissolved in 2-propanol and charged into the other additional funnel. Fifty percent of the monomer solution was charged into the round bottom flask and then degassed with N 2 . The solution was brought to reflux and fifty percent of the AIBN solution was charged into the system. The rest of the monomer solution and AIBN solution was slowly added via an hour period. After additions were complete, the reaction was allowed to reflux for 12 hours. The mixture was allowed to cool to room temperature, and was then precipitated in ethyl acetate. Solids were isolated by decanting off ethyl acetate and dried at 60°C vacuum oven. The material was analyzed by H 1 -NMR, C 13 -NMR and FTIR. This polymerized product is referred to as MAPTAC/n-Ethyl maleimide no. 3. Modification of Proteinaceous Substrate with Maleimide-co-styrene no. 1 and Cationic styrene-maleimide no. 2 Experiment #1 consisted of applying a 10 wt% solution of maleimide-co- styrene no. 1 to hair and allowing the solution to remain in contact with the hair for 40 minutes. Following this step, a pH = 10 buffer solution was applied to hair and the hair was heated to 45°C for 40 minutes. Following this treatment, the hair was washed and rinsed 1, 5, 10, and 20 times with a 10 wt% aqueous solution of sodium lauryl sulfate and the work of wet comb was measured quantitatively using a modified tensile testing apparatus. Experiment #2 consisted of applying a 10% (mass) solution of maleimide-co-styrene no. land allowing the solution to remain in contact with the hair for 40 minutes. Following this treatment, the hair was washed and rinsed 1 , 5, 10, and 20 times with a 10% (mass) solution of sodium lauryl sulfate and water and work of wet comb was measured quantitatively using a modified tensile testing apparatus. This experiment differed from Experiment #1 in that polymer modified hair did not undergo a pH adjustment. Experiment #3 consisted of applying a 10% (mass) solution of cationic styrene-maleimide no. 2 and allowing the solution to remain in contact with the hair for 40 minutes. Following this step, a pH = 10 buffer solution was applied to hair and the hair was heated to 45°C for 40 minutes. Following this treatment, the hair was washed and rinsed 1 , 5, 10, and 20 times with a 10% (mass) aqueous solution of sodium lauryl sulfate and work of wet comb was measured quantitatively using a modified tensile testing apparatus. This experiment differed from Experiment #1 in that the polymer employed lacked imide functionality. Experiment #4 consisted of washing and rinsing hair 1 , 5, 10, and 20 times in a 10% (mass) aqueous solution of sodium lauryl sulfate and measuring work of wet comb quantitatively using a modified tensile testing apparatus. The results of the experiments are graphically depicted in the Figure below where they are plotted as % reduction in work of wet comb vs. # of washes with a 10% sodium lauryl sulfate solution. % Reduction in work of wet comb is calculated as (W 0 -W)/W 0 , where W is the work of wet comb after a wash/rinse and W 0 is the initial work of wet comb of the hair before any modification. Those instances where the measured work of wet comb was in excess of the initial work of wet comb were assigned a negative value whereas those instances where the measured work of wet comb was less than the initial work were assigned a positive value. Hence a negative value indicates that hair is more difficult to comb while a positive value indicates that the hair is easier to comb. % Reduction in Work of Wet Comb vs. # of Washes in 10% Sodium Lauryl Sulfate - Experiment 1 - Experiment 2 - Experiment 3 - Experiment 4 # of Washes in 10% Sodium Lauryl Sulfate As can be seen in the Figure above, the imide functionality is critical to promote an improvement in combability that persists for at least 20 washes. In addition, the Figure 1 demonstrates that the mode of application of the polymer is critical to promote an improvement in combability that persists for at least 20 washes. Furthermore, the action of cleansing hair provides no influence on the combability when not accompanied by treatment with such polymers. Modification of Proteinaceous Substrate with MAPTAC/n-Ethyl maleimide no. 3 The experiment consisted of applying a 10 wt% solution of MAPTAC/n- Ethyl maleimide no. 3 to hair and allowing the solution to remain in contact with the hair for 40 minutes. Following this step, a pH = 10 buffer solution was applied to hair and the hair was heated to 45°C for 40 minutes. Following this treatment, the hair was washed and rinsed 1 , 5, 10, and 20 times with a 10 wt% aqueous solution of sodium lauryl sulfate and the work of wet comb was measured quantitatively using a modified tensile testing apparatus. The Figure below plots the % of original work of wet comb vs. # of washes in SLS Based Shampoo. As can be seen by this plot, the subject polymer provides approximately 45% reduction in work of wet comb that persists over the course of 20 cleansing cycles. Examples The following examples demonstrate the preparation of polyimido compounds based upon silicones. Preparation of Silicone Bearing Phthalimide Functionality (Silicone Bearing Phthalimide no. 1) Aminopropylmethylsiloxane-co-dimethylsiloxane (2-10 mole% amine) was dissolved in THF. One mole equivalent (relative to the amino groups on silicone) of phthalic anhydride or succinic anhydride (relative to the amino groups on silicone) in THF was added to the silicone solution. The resulting mixture was stirred for 20 minutes. THF was evaporated. The resulting amino acid silicone was heated at 170°C in vacuum oven (20 torr) for 3 hours. The resulting light yellow oil was analyzed by 1 H-NMR, 13 C-NMR and FTIR and confirmed to be the desired phthalimide or succinimide modified silicone. This silicone bearing phthalimide is referred to as silicone bearing phthalimide no. 1 in the following hair tests. Synthesis of silicone-PEG-phthalimide polymer A 250ml, 4-neck round bottom flask was equipped with a N 2 inlet topped condenser, thermometer, and magnetic stirrer. The reaction was conducted under a N 2 blanket. 2.34g of phthalic anhydride and 50ml of THF was charged into the round bottom flask. The mixture was stirred at room temperature to dissolve the phthalic anhydride. Once the phthalic anhydride dissolved, 100g of poly[dimethyl siloxane-co-methyl-(3-hydroxypropyl siloxane]-graft-(polyethylene glycol) was charged into the solution. The temperature was adjusted to 60°C. The reaction was monitored using FT-IR. Once the reaction was complete, the solution was precipitated in heptane. Solids were allowed to settle and heptane was decanted off. Additional heptane was removed using a rotary evaporator and Kugelrohr. The phthalic acid intermediate was isolated as an oil. The phthalic acid was then heated at 130°C in a vacuum oven (20 torr) for 1.5 hours to form the phthalimide. Synthesis of maleimide-silicone polymer A 250ml, 4-neck round bottom flask was equipped with a N 2 inlet topped condenser, thermometer, and magnetic stirrer. The reaction was conducted under a N 2 blanket. 2.84g of maleic anhydride and 50ml of THF was charged into the round bottom flask. The mixture was stirred at room temperature to dissolve the maleic anhydride. Once a solution formed, 25g of dimethyl(10%)aminopropylmethylsiloxane was charged into the reaction. The temperature was then adjusted to 60°C. The reaction was monitored using FT-IR. Once the reaction was complete, THF was removed using a rotary evaporator. The resulting amino acid intermediate was dissolved in acetic anhydride. 0.04g of sodium acetate was also added. The resulting solution was brought to reflux. The reaction was monitored by FT-IR. Once the reaction was complete, acetic anhydride was vacuum stripped off using a Kugelrohr. The product was isolated as an oil. 4-Modification of Proteinaceous Substrate with Silicone Bearing Phthalimide no. 1 The following application method was employed to apply the phthalimide modified silicone to bleached and permed hair. Ten milliliters of a 5 wt% solution of polymer in ethanol were massaged into each 2.5g (12 inch) tress of hair. After application, the tresses were allowed to stand at room temperature for 20 minutes. After 20 minutes, ten milliliters of pH = 10.5 buffer solution (0.025 mole sodium carbonate/sodium bicarbonate) solution were massaged into each tress and placed in a 45°C convection oven for 40 minutes. The work of wet comb was measured quantitatively using a modified tensile testing apparatus. The Figure below plots the percentage of original work of wet comb for hair treated with phthalimide modified silicone vs. number of washes in SLS Based Shampoo. Original work was measured with hair that was not treated with the polymer. As can be seen by this plot, the subject polymer provides approximately 65% reduction in work of wet comb that persists over the course of 20 cleansing cycles. Preparation of Polysaccharide Copolymers The following examples demonstrate the preparation of polysaccharide copolymers useful for the modification of proteinaceous substrate. Preparation of Phthalimide/HEC (Phthalimide/HEC no. 1) Fifty grams of HEC (Clariant Tylose H4000, G4PHA Mw = 250000- 300000), 8.5 g of N-epoxypropyl phthalimide were well mixed with 322 ml of 92% isopropanol/water solution with mechanical stirrer. About 8 ml of 6.25N sodium hydroxide solution was added slowly through an additional funnel until the pH of the mixture reached 11.5-12. The resulting mixture was stirred at room temperature for half an hour. The temperature of the reaction mixture was then raised to 50°C and kept stirring for 20 hours. After cooled to room temperature, the pH of the mixture was adjusted to 1.5-2 with 2N hydrochloride solution. The mixture was filtered and the resulting wet cake was re-suspended twice with 92% isopropanol/water solution and twice with pure isopropanol. This amic acid modified HEC was then dried in vacuum oven overnight to remove the residue isopropanol and water. The dried white powder was then heated at 180-200°C for one hour to give the desired product. Both the intermediate and the final product was analyzed by NMR, FTIR and Nitrogen Analysis for to confirm the structure and the degree of substitution of imide. This compound is referred to as phthalimide/HEC no. 1. Modification of Proteinaceous Substrate with Phthalimide/HEC no. 1 The following application method was employed to apply the polymer to bleached and permed hair. Ten milliliters of a 10 wt% dispersion of polymer were massaged into each 2.5g (12 inch) tress of hair. After application, the tresses were allowed to stand at room temperature for 60 minutes. After 60 minutes, ten milliliters of pH = 10.5 buffer solution (0.025 mole sodium carbonate/sodium bicarbonate) solution were massaged into each tress and placed in a 45°C convection oven for 60 minutes. In addition to the subject polymer, a cationic hydroxyethyl cellulose derivative (CELQUAT SC240SC) and a blank were tested. The Figure below plots the percentage of original work of wet comb for hair treated with imidized HEC vs. number of washes in SLS Based Shampoo. Original work was measured with hair that was not treated with the polymer. As can be seen by this plot, the subject polymer provides approximately 40% reduction in work of wet comb that persists over the course of 20 cleansing cycles. The cationic hydroxyethyl cellulose displays a transient improvement in wet combability over the course of the 20 cleansing cycles and the blank essentially shows no change. Durability of % of Original Work of Wet Comb . Cationic HEC . Imidized HEC . Blank 0 10 20 # of Washes in SLS Base Shampoo Examples These examples describes efforts to determine if the phthalimide reactive functionality is an acylating agent and capable of acylating under suitable conditions. Two model compounds, N-hydroxyethylphthalimide and N- hydroxyethylsuccinimide, were investigated regarding hydrolysis in water at pH=10, 40°C and reaction with butylamine as shown in the Scheme below. Both phthalimide (3hrs) and succinimide (2hrs) were hydrolyzed rather rapidly although N-hydroxyethylphthalimide does not dissolve in water at the beginning of hydrolysis. Aminolysis of phthalimide was run in DMF and 95% of amine reacted after 2 hours. The same reaction for succinimide was run in methanol and the reaction was much slower. FTIR suggested the completion of the amminolysis after 15 hours. However, after the product was dried under reduced pressure at room temperature overnight, about 25% of the amine was detected in the reaction mixture from NMR. The Scheme below illustrates the aminolysis and hydrolysis of N-hydroxyethylphthalimide and N- hydroxyethylsuccinimide. Aminolysis of succinimide were also conducted using one equivalent butylamine in pH=10 buffer solution at 40°C for two hours. NMR indicated a ratio of diamide:amide acid:imide =1:4:1 in the product mixture. The same experiment was run for phthalimide for 3.5 hours and NMR revealed that close to 38% of phthalimide was converted to diamide and About 13% amide acid. It seems that the aminolysis of phthalimide is much more selective over hydrolysis than succinimide under the given conditions. It seems that the aminolysis of phthalimide is much more selective over hydrolysis than succinimide under the given conditions. This suggests that the phthalimide reactive groups is competent to acylate nucleophilic groups found on/in proteinaceous substrates. While a number of embodiments of this invention have been represented, it is apparent that the basic construction can be altered to provide other embodiments which utilize the invention without departing from the spirit and scope of the invention. All such modifications and variations are intended to be included within the scope of the invention as defined in the appended claims rather than the specific embodiments which have been presented by way of example.

Claims: We claim: 1. A method for treating a proteinaceous substrate which comprises the steps of: (a) contacting a proteinaceous substrate with an aqueous solution/dispersion of an imido or polyimido compound at a pH value between about 4 and about 7 for a time sufficient to allow the imido or polyimido compound to be adsorbed/absorbed on or into the proteinaceous substrate; and (b) raising the pH value of the imido or polyimido compound adsorbed/absorbed on or into the proteinaceous substrate above about 7 for a time sufficient to allow the imido or polyimido compound to react with the proteinaceous substrate. 2. The method according to claim 1 , wherein the molecular weight of the imido or polyimido compound is from about 300 to about 1 ,000,000. 3. The method according to claim 1, wherein the proteinaceous substrate is selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails. 4. The method according to claim 1, wherein the pH value of the imido or polyimido compound adsorbed/absorbed on or into the proteinaceous substrate in step (b) is raised above about 7 employing a solvent in which the imido or polyimido compound is substantially insoluble. 5. A proteinaceous substrate having an imido or polyimido compound covalently bonded to a portion thereof. 6. The proteinaceous substrate according to claim 5, wherein the molecular weight of the imido or polyimido compound is from about 300 to about 1 ,000,000. 7. The proteinaceous substrate according to claim 5, wherein the proteinaceous substrate is selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails. 8. A method for treating a proteinaceous substrate which comprises the steps of: (a) contacting a proteinaceous substrate with an aqueous solution of a polyimido compound at a pH value between about 4 and about 7 for a time sufficient to allow the polyimido compound to be adsorbed/absorbed on or into the proteinaceous substrate; and (b) raising the pH value of the polyimido compound adsorbed/absorbed on or into the proteinaceous substrate above about 7 for a time sufficient to allow the polyimido compound to react with the proteinaceous substrate; wherein the polyimido compound is selected from the group consisting of polysuccinimide compounds represented by Formula (1): I w J n, L ' n 2 (1) polyglutimide compounds represented by Formula (2); (2) and copolymers of the polysuccinimide compounds represented by Formula (1) with the polyglutimide compounds represented by Formula (2); wherein W is a water-solubilizing/dispersing moiety that provides water-solubility and/or water-dispersibility to the polyimido compound; the ratio of ^ to n 2 is from about 1 :99 to about 99:1 ; and the molecular weight of the polyimido compound is from about 300 to about 1 ,000,000. 9. The method according to claim 8, wherein W is derived from a nucleophilic moiety selected from the group consisting of amines, alcohols, phenols, thiols, and carboxylates. 10. The method according to claim 9, wherein W is selected from the group consisting of: (1) aminopolysaccharides represented by the formula, -N(R 1 )-polysaccharide, wherein R is hydrogen or lower alkyl and the number of units in the polysaccharide ranges from 1 to about 51; (2) amines containing quaternary ammonium salts represented by the formula, [-N(R 1 )(CH 2 ) n3 N + (CH 3 ) 3 ][A " ], wherein R is hydrogen or lower alkyl, n 3 is an integer from 1 to about 10, and A is a monovalent anion; (3) amines containing alcohols represented by the formula, -N(R 1 )(CH 2 ) n4 OH, wherein Ri is hydrogen or lower alkyl and n is an integer from 2 to about 10; (4) amines containing polyalkoxylated alcohols represented by the formula, -N(R 1 )CH(CH 3 )CH 2 -(OCHR 2 CH 2 ) n 5-OCH 3 , wherein ^ is hydrogen or lower alkyl, R 2 may be hydrogen or methyl, and n 5 is an integer from 0 to about 50; (5) thiols containing alcohols represented by the formula, -S(CH 2 ) n6 OH, wherein n 6 is an integer ranging from 2 to about 10; (6) alcohols containing ethers represented by the formula, -O(CH 2 CH 2 O) n OM, wherein n 7 is an integer ranging from 0 to about 50 and M is an alkyl group containing from 1 to about 30 carbons; (7) -O " X + , where X is selected from the group consisting of H + , Na + , Li + , NH 4 + , NH(CH 3 ) 3 + ; NH 3 (CH 2 CH 2 OH) + , NH 2 (CH 2 CH 2 OH) 2 + , and NH(CH 2 CH 2 OH) 3 + ; and (8) [-NH(CH 2 )3N + (CH 3 ) 2 CH 2 COONa][A-], -N(CH 3 )(CH 2 ) 2 SO 3 Na, and -NH(CH 2 ) 2 SO 3 Na, wherein A is a monovalent anion. 11. The method according to claim 8, wherein the ratio of ni to n 2 is from about 95:5 to about 5:95. 12. The method according to claim 8, wherein the molecular weight of the polyimido compound is from about 300 to about 5000. 13. The method according to claim 8, wherein the molecular weight of the polyimido compound is greater than about 5000. 14. The method according to claim 8, wherein the polyimido compound is a polysuccinimide represented by Formula (1). 15. The method according to claim 8, wherein the polyimido compound is a polyglutimide represented by Formula (2). 16. The method according to claim 8, wherein the polyimido compound is a copolymer of the polysuccinimide represented by Formula (1 ) with the polyglutimide represented by Formula (2). 17. The method according to claim 8, wherein the proteinaceous substrate is selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails. 18. The method according to claim 8, wherein the polyimido compound is cross-linked with a multifunctional nucleophilic agent. 19. The method according to claim 18, wherein the multifunctional nucleophilic agent is selected from the group consisting of 1 , 6- hexamethylenediamine, polyethyleneimines, polyalkoxides, and polythiols. 20. The method according to claim 8, wherein the water- solubilizing/dispersing moiety bears an ionic charge and is electrostatically bound to a moiety bearing the opposite charge. 21. The method according to claim 20, wherein the moiety bearing the opposite charge is selected from the group consisting of antimicrobials, ultraviolet chromophores, anionic dyes, anti-oxidants, fluorescing agents, brightening agents, shine and gloss enhancers, softening agents, and conditioning agents. 22. The method according to claim 8, wherein the pH value of the polyimido compound adsorbed/absorbed on or into the proteinaceous substrate in step (b) is raised above about 7 employing a solvent in which the polyimido compound is substantially insoluble. 23. The method according to claim 22, wherein the solvent employed is selected from the group consisting of C 2 -C 3 alcohols, aqueous mixtures of C 2 - C 3 alcohols, and mixtures thereof. 24. A proteinaceous substrate, having a polyimido compound covalently bonded to a portion thereof, wherein the polyimido compound is derived from a residue selected from the group consisting of polysuccinimide compounds represented by Formula (1): I w -i n, L ' n 2 (1) polyglutimide compounds represented by Formula (2); w -I n, L ' n 2 (2) and copolymers of the polysuccinimide compounds represented by Formula (1) with the polyglutimide compounds represented by Formula (2); wherein W is a water-solubilizing/dispersing moiety that provides water-solubility and/or water-dispersibility to the polyimido compound; the ratio of n, to n 2 is from about 1 :99 to about 99:1; and the molecular weight of the polyimido compound is from about 300 to about 1 ,000,000. 25. The proteinaceous substrate according to claim 24, wherein W is derived from a nucleophilic moiety selected from the group consisting of amines, alcohols, phenols, thiols, and carboxylates. 26. The proteinaceous substrate according to claim 25, wherein W is selected from the group consisting of: (1) aminopolysaccharides represented by the formula, -N(R 1 )-polysaccharide, wherein R, is hydrogen or lower alkyl and the number of units in the polysaccharide ranges from 1 to about 51; (2) amines containing quaternary ammonium salts represented by the formula, [-N(R 1 )(CH 2 ) n3 N + (CH 3 ) 3 ][A ], wherein R, is hydrogen or lower alkyl, n 3 is an integer from 1 to about 10, and A is a monovalent anion; (3) amines containing alcohols represented by the formula, -N(R 1 )(CH 2 ) n4 OH, wherein R, is hydrogen or lower alkyl and n is an integer from 2 to about 10; (4) amines containing polyalkoxylated alcohols represented by the formula, -N R CHtCHaJCH-HOCHRzCHi ns-OCHa, wherein R, is hydrogen or lower alkyl, R 2 may be hydrogen or methyl, and n 5 is an integer from 0 to about 50; (5) thiols containing alcohols represented by the formula, -S(CH 2 ) n6 OH, wherein n 6 is an integer ranging from 2 to about 10; (6) alcohols containing ethers represented by the formula, -O(CH 2 CH 2 O) n OM, wherein n 7 is an integer ranging from 0 to about 50 and M is an alkyl group containing from 1 to about 30 carbons; (7) -O " X + , where X is selected from the group consisting of H + , Na + , Li + , NH \ NH(CH 3 ) 3 + ; NH 3 (CH 2 CH 2 OH) + , NH 2 (CH 2 CH 2 OH) 2 + , and NH(CH 2 CH 2 OH) 3 + ; and (8) [-NH(CH 2 ) 3 N + (CH 3 ) 2 CH 2 COONa][A ], -N(CH 3 )(CH 2 ) 2 SO 3 Na, and -NH(CH 2 ) 2 SO 3 Na, wherein A is a monovalent anion. 27. The proteinaceous substrate according to claim 24, wherein the ratio of n-i to n 2 is from about 95:5 to about 5:95. 28. The proteinaceous substrate according to claim 24, wherein the molecular weight of the polyimido compound is from about 300 to about 5000. 29. The proteinaceous substrate according to claim 24, wherein the molecular weight of the polyimido compound is greater than about 5000. 30. The proteinaceous substrate according to claim 24, wherein the polyimido compound is a polysuccinimide represented by Formula (1). 31. The proteinaceous substrate according to claim 24, wherein the polyimido compound is a polyglutimide represented by Formula (2). 32. The proteinaceous substrate according to claim 24, wherein the polyimido compound is a copolymer of the polysuccinimide represented by Formula (1) with the polyglutimide represented by Formula (2). 33. The proteinaceous substrate according to claim 24, wherein the proteinaceous substrate is selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails. 34. The proteinaceous substrate according to claim 24, wherein the polyimido compound is cross-linked with a multifunctional nucleophilic agent. 35. The proteinaceous substrate according to claim 34, wherein the multifunctional nucleophilic agent is selected from the group consisting of 1 , 6-hexamethylenediamine, polyethyleneimines, polyalkoxides, and polythiols. 36. The proteinaceous substrate according to claim 24, wherein the water-solubilizing/dispersing moiety bears an ionic charge and is electrostatically bound to a moiety bearing the opposite charge. 37. The proteinaceous substrate according to claim 36, wherein the moiety bearing the opposite charge is selected from the group consisting of antimicrobials, ultraviolet chromophores, anionic dyes, anti-oxidants, fluorescing agents, brightening agents, shine and gloss enhancers, softening agents, and conditioning agents. 38. A polyimido compound selected from the group consisting of polysuccinimide compounds represented by Formula (1): i r -CHCONH- -CH-CO I I I CH. I N- I I I C(O) CH 2 -CO I w -I n, L ' n 2 (1) polyglutimide compounds represented by Formula (2); w J n, ' n 2 (2) and copolymers of the polysuccinimide compounds represented by Formula (1) with the polyglutimide compounds represented by Formula (2); wherein W is a water-solubilizing/dispersing moiety that provides water-solubility and/or water-dispersibility to the polyimido compound; the ratio of n, to n 2 is from about 1:99 to about 99:1 ; and the molecular weight of the polyimido compound is from about 300 to about 1 ,000,000. 39. The polyimido compound according to claim 38, wherein W is derived from a nucleophilic moiety selected from the group consisting of amines, alcohols, phenols, thiols, and carboxylates. 40. The polyimido compound according to claim 39, wherein W is selected from the group consisting of: (1) aminopolysaccharides represented by the formula, -N(R 1 )-polysaccharide, wherein R, is hydrogen or lower alkyl and the number of units in the polysaccharide ranges from 1 to about 51 ; (2) amines containing quaternary ammonium salts represented by the formula, [-N(R 1 )(CH 2 ) n3 N + (CH 3 ) 3 ][A ], wherein R, is hydrogen or lower alkyl, n 3 is an integer from 1 to about 10, and A is a monovalent anion; (3) amines containing alcohols represented by the formula, -N(R 1 )(CH 2 ) n4 OH, wherein R, is hydrogen or lower alkyl and n 4 is an integer from 2 to about 10; (4) amines containing polyalkoxylated alcohols represented by the formula, -N(Rι)CH(CH 3 )CH 2 -(OCHR 2 CH 2 ) n5 -OCH 3 , wherein R^ is hydrogen or lower alkyl, R 2 may be hydrogen or methyl, and n 5 is an integer from 0 to about 50; (5) thiols containing alcohols represented by the formula, -S(CH 2 ) n6 OH, wherein n 6 is an integer ranging from 2 to about 10; (6) alcohols containing ethers represented by the formula, -O(CH 2 CH 2 O) n OM, wherein n 7 is an integer ranging from 0 to about 50 and M is an alkyl group containing from 1 to about 30 carbons; (7) -O " X + , where X is selected from the group consisting of H + , Na + , Li\ NH 4 + , NH(CH 3 ) 3 + ; NH 3 (CH 2 CH 2 OH)\ NH 2 (CH 2 CH 2 OH) 2 + , and NH(CH 2 CH 2 OH) 3 + ; (8) [-NH(CH 2 ) 3 N + (CH 3 ) 2 CH 2 COONa][A ], -N(CH 3 )(CH 2 ) 2 SO 3 Na, and -NH(CH 2 ) 2 SO 3 Na, wherein A is a monovalent anion. 41. The polyimido compound according to claim 38, wherein the ratio of n, to n 2 is from about 95:5 to about 5:95. 42. The polyimido compound according to claim 38, wherein the molecular weight of the polyimido compound is from about 300 to about 5,000. 43. The polyimido compound according to claim 38, wherein the molecular weight of the polyimido compound is greater than about 5,000. 44. The polyimido compound according to claim 38, wherein the polyimido compound is a polysuccinimide represented by Formula (1). 45. The polyimido compound according to claim 38, wherein the polyimido compound is a polyglutimide represented by Formula (2). 46. The polyimido compound according to claim 38, wherein the polyimido compound is a copolymer of the polysuccinimide represented by Formula (1) with the polyglutimide represented by Formula (2). 47. A method for treating a proteinaceous substrate which comprises the steps of: (a) contacting a proteinaceous substrate with an aqueous solution of an imido compound at a pH value between about 4 and about 7 for a time sufficient to allow the imido compound to be adsorbed/absorbed on or into the proteinaceous substrate; and (b) raising the pH value of the imido compound adsorbed/absorbed on or into the proteinaceous substrate above about 7 for a time sufficient to allow the imido compound to react with the proteinaceous substrate; wherein the imido compound is represented by Formula (3): — CH • CH— 0=C • N =0 \ΛΛ (3) wherein W, is a water-solubilizing/dispersing moiety that provides water- solubility and/or water-dispersibility to the imido compound; R 3 is selected from the group consisting of hydrogen, C C 12 branched and unbranched alkyl, aryl, aralkyl, and alkaryl; Y is the residue of an ethylenically unsaturated hydrophilic monomer that provides water-solubility and/or water-dispersibility to the imido compound; Z is the residue of an ethylenically unsaturated monomer that provides structural units to the imido compound; the molecular weight of the imido compound is from about 300 to about 2,000,000; n 8 is from about 0 to about 100; n 9 is from about 0 to about 99; n 10 is from about 0 to about 99; and nn is from about 0 to about 99; with the proviso that when n 8 is zero, n 9 and n 0 are not zero. 48. The method according to claim 47, wherein W, is a hydrophilic group selected from the group consisting of anionic, cationic, zwitterioinc, and polar non-ionic functional groups. 49. The method according to claim 48, wherein W, is selected from the group consisting of: (1) saccharides or polysaccharides wherein the number of units in the polysaccharide ranges from 1 to about 51 ; (2) quaternary ammonium salts represented by the formula, [(CH 2 ) n3 N + (CH 3 ) 3 ][A " ], wherein n 3 is an integer from 1 to about 10 and A is a monovalent anion; (3) alcohols represented by the formula, (CH 2 ) n4 OH, wherein n 4 is an integer from 2 to about 10; (4) polyalkoxylated alcohols represented by the formula, -CH(CH 3 )CH 2 .(OCHR 2 CH 2 ) n 5-OCH 3 , wherein R 2 may be hydrogen or methyl, and n 5 is an integer from 0 to about 50; and (5) [-(CH 2 ) 3 N + (CH 3 ) 2 CH 2 COONa][A], [-(CHa^N^CHa^CHzCHzC^SOsNajlVA- ], -(CH 3 )(CH 2 ) 2 SO 3 Na, and -(CH 2 ) 2 SO 3 Na, wherein A is a monovalent anion. 50. The method according to claim 47, wherein R 3 is a C 1 -C 4 branched or unbranched alkyl group. 51. The method according to claim 47, wherein Y is selected from the group consisting of anionic, cationic, zwitterionic, and nonionic monomers. 52. The method according to claim 51, wherein Y is selected from the group of anionic monomers consisting of (meth)acrylic acid, crotonic acid, maleic acid, fumaric acid, itaconic acid, maleic anhydride, fumaric anhydride, itaconic anhydride, methyl hydrogen fumarate, butyl hydrogen fumarate, ethyl hydrogen maleate, butyl hydrogen maleate, allyloxy-benzene-sulfonate monomers, methallylsulfonate, styrene sulfonic acid, acrylamido alkyl sulfonates, aryl sulfonates, vinyl sulfonic acid, vinyl phosphonic acid, and the alkali, alkaline earth, and ammonium salts thereof. 53. The method according to claim 51, wherein Y is selected from the group of cationic monomers consisting of (3-acrylamidopropyl) trimethylammonium chloride, [2-(acryloyloxy)ethyl] trimethylammonium methyl sulfate, 2-(dimethylamino) ethyl acrylate, [3- (methacryloylamino)propyl] trimethylammonium chloride, [2- (methacryloyloxy)ethyl] trimethylammonium chloride, [2- (methacryloyloxy)ethyl] trimethylammonium methyl sulfate, 2- (dimethylamino)ethyl methacrylate, 2-aminoethyl methacrylate hydrochloride, diallyl-dimethyl-ammonium chloride, vinyl imidazole, vinyl pyridine including substituted derivatives thereof, and quatemized vinyl pyridine. 54. The method according to claim 51 , wherein Y is selected from the group of zwitterionic monomers consisting of unsaturated carboxyl, sulfoxyl, and sulfate-substituted amines. 55. The method according to claim 51, wherein Y is selected from the group of nonionic monomers consisting of C 1-4 hydroxy alkyl esters of (meth)acrylic acid, vinyl formamide, vinyl acetamide, 1-vinyl-2-pyrrolidinone, methacrylamide, acrylamide, C^ mono- and dialkyl substituted (meth)acrylamides, acrylonitrile, methacrylonitrile, and polymerizable saccharide-derived monomers. 56. The method according to claim 51, wherein Y is the residue of an ethylenically unsaturated hydrophilic vinyl alcohol monomer. 57. The method according to claim 51, wherein Y is selected from the group consisting of [3-(methacryloylamino)propyl] trimethylammonium chloride, diallyl-dimethyl-ammonium chloride, methacrylic acid, acrylic acid, 2- acrylamido-2-methyl propane sulfonic acid, polymerizable saccharide-derived monomers, and the alkali, alkaline earth, and ammonium salts thereof. 58. The method according to claim 47, wherein Z is selected from the group consisting of esters and amides of acrylic acid and methacrylic acid, vinyl aromatic compounds, vinyl esters, vinyl amides, vinyl ethers, ethylenically unsaturated nitriles, 1-butene, 1,3,butadiene, and substituted derivatives thereof. 59. The method according to claim 58, wherein Z is selected from the group consisting of C^ alkyl esters of acrylic acid and methacrylic acid, vinyl ethers, vinyl esters, and styrene. 60. The method according to claim 47, wherein the molecular weight of the imido compound is from about 300 to about 5,000. 61. The method according to claim 47, wherein the molecular weight of the imido compound is greater than about 5,000. 62. The method according to claim 47, wherein n 8 is from about 1 to about 99; n 9 is from about 0 to about 99; n 10 is from about 0 to about 99; and rin is from about 1 to about 99. 63. The method according to claim 47, wherein n 8 is from about 0 to about 99; n 9 is from about 1 to about 99; n 10 is from about 1 to about 99; and rin is from about 0 to about 99. 64. The method according to claim 47, wherein the proteinaceous substrate is selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails. 65. The method according to claim 47, wherein the imido compound is cross-linked with a multifunctional nucleophilic agent. 66. The method according to claim 65, wherein the multifunctional nucleophilic agent is selected from the group consisting of 1 , 6- hexamethylenediamine, polyethyleneimines, polyalkoxides, and polythiols. 67. The method according to claim 47, wherein the imido compound bears an ionic charge and is electrostatically bound to a moiety bearing the opposite charge. 68. The method according to claim 47, wherein the moiety bearing the opposite charge is selected from the group consisting of antimicrobials, ultraviolet chromophores, anionic dyes, anti-oxidants, fluorescing agents, brightening agents, shine and gloss enhancers, softening agents, and conditioning agents. 69. The method according to claim 47, wherein the pH value of the imido compound adsorbed/absorbed on or into the proteinaceous substrate in step (b) is raised above about 7 employing a solvent in which the imido compound is substantially insoluble. 70. The method according to claim 69, wherein the solvent employed is selected from the group consisting of C 2 -C 3 alcohols, aqueous mixtures of C 2 - C 3 alcohols, and mixtures thereof. 71. A proteinaceous substrate, having an imido compound covalently bonded to a portion thereof, wherein the imido compound is derived from a residue represented by Formula (3): (3) wherein Wi is a water-solubilizing/dispersing moiety that provides water- solubility and/or water-dispersibility to the imido compound; R 3 is selected from the group consisting of hydrogen, C C 12 branched and unbranched alkyl, aryl, aralkyl, and alkaryl; Y is the residue of an ethylenically unsaturated hydrophilic monomer that provides water-solubility and/or water-dispersibility to the imido compound; Z is the residue of an ethylenically unsaturated monomer that provides structural units to the imido compound; the molecular weight of the imido compound is from about 300 to about 2,000,000; n 8 is from about 0 to about 100; n 9 is from about 0 to about 99; n 10 is from about 0 to about 99; and nn is from about 0 to about 99; with the proviso that when n 8 is zero, n 9 and n 10 are not zero. 72. The proteinaceous substrate according to claim 71, wherein W, is a hydrophilic group selected from the group consisting of anionic, cationic, zwitterioinc, and polar non-ionic functional groups. 73. The proteinaceous substrate according to claim 72, wherein W, is selected from the group consisting of: (1) saccharides or polysaccharides wherein the number of units in the polysaccharide ranges from 1 to about 51 ; (2) quaternary ammonium salts represented by the formula, [(CH 2 ) n3 N + (CH 3 ) 3 ][A " ], wherein n 3 is an integer from 1 to about 10 and A is a monovalent anion; (3) alcohols represented by the formula, (CH 2 ) n4 OH, wherein n is an integer from 2 to about 10; (4) polyalkoxylated alcohols represented by the formula, -CH(CH 3 )CH 2 -(OCHR 2 CH 2 )n5-OCH 3 , wherein R 2 may be hydrogen or methyl, and n 5 is an integer from 0 to about 50; and (5) [-(CH 2 ) 3 N + (CH 3 ) 2 CH 2 COONa][A ], [-(CH 2 ) 3 N + (CH 3 ) 2 CH 2 CH 2 CH 2 SO 3 Na][A- ], -(CH 3 )(CH 2 ) 2 SO 3 Na, and -(CH 2 ) 2 SO 3 Na, wherein A is a monovalent anion. 74. The proteinaceous substrate according to claim 71 , wherein R 3 is a C C branched or unbranched alkyl group. 75. The proteinaceous substrate according to claim 71 , wherein Y is selected from the group consisting of anionic, cationic, zwitterionic, and nonionic monomers. 76. The proteinaceous substrate according to claim 75, wherein Y is selected from the group of anionic monomers consisting of (meth)acrylic acid, crotonic acid, maleic acid, fumaric acid, itaconic acid, maleic anhydride, fumaric anhydride, itaconic anhydride, methyl hydrogen fumarate, butyl hydrogen fumarate, ethyl hydrogen maleate, butyl hydrogen maleate, allyloxy-benzene-sulfonate monomers, methallylsulfonate, styrene sulfonic acid, acrylamido alkyl sulfonates, aryl sulfonates, vinyl sulfonic acid, vinyl phosphonic acid, and the alkali, alkaline earth, and ammonium salts thereof. 77. The proteinaceous substrate according to claim 75, wherein Y is selected from the group of cationic monomers consisting of (3- acrylamidopropyl) trimethylammonium chloride, [2-(acryloyloxy)ethyl] trimethylammonium methyl sulfate, 2-(dimethylamino) ethyl acrylate, [3- (methacryloylamino)propyl] trimethylammonium chloride, [2- (methacryloyloxy)ethyl] trimethylammonium chloride, [2- (methacryloyloxy)ethyl] trimethylammonium methyl sulfate, 2- (dimethylamino)ethyl methacrylate, 2-aminoethyl methacrylate hydrochloride, diallyl-dimethyl-ammonium chloride, vinyl imidazole, vinyl pyridine including substituted derivatives thereof, and quaternized vinyl pyridine. 78. The proteinaceous substrate according to claim 75, wherein Y is selected from the group of zwitterionic monomers consisting of unsaturated carboxyl, sulfoxyl, and sulfate-substituted amines. 79. The proteinaceous substrate according to claim 75, wherein Y is selected from the group of nonionic monomers consisting of Ci-,, hydroxy alkyl esters of (meth)acrylic acid, vinyl formamide, vinyl acetamide, 1-vinyl-2- pyrrolidinone, methacrylamide, acrylamide, C^ mono- and dialkyl substituted (meth)acrylamides, acrylonitrile, methacrylonitrile, and polymerizable saccharide-derived monomers. 80. The proteinaceous substrate according to claim 75, wherein Y is the residue of an ethylenically unsaturated hydrophilic vinyl alcohol monomer. 81. The proteinaceous substrate according to claim 75, wherein Y is selected from the group consisting of [3-(methacryloylamino)propyl] trimethylammonium chloride, diallyl-dimethyl-ammonium chloride, methacrylic acid, acrylic acid, 2-acrylamido-2-methyl propane sulfonic acid, polymerizable saccharide-derived monomers, and the alkali, alkaline earth, and ammonium salts thereof. 82. The proteinaceous substrate according to claim 71 , wherein Z is selected from the group consisting of esters and amides of acrylic acid and methacrylic acid, vinyl aromatic compounds, vinyl esters, vinyl amides, vinyl ethers, ethylenically unsaturated nitriles, 1-butene, 1 ,3,butadiene, and substituted derivatives thereof. 83. The proteinaceous substrate according to claim 82, wherein Z is selected from the group consisting of C^ alkyl esters of acrylic acid and methacrylic acid, vinyl ethers, vinyl esters, and styrene. 84. The proteinaceous substrate according to claim 71, wherein the molecular weight of the imido compound is from about 300 to about 5,000. 85. The proteinaceous substrate according to claim 71 , wherein the molecular weight of the imido compound is greater than about 5,000. 86. The proteinaceous substrate according to claim 71 , wherein n 8 is from about 1 to about 99; ng is from about 0 to about 99; n 10 is from about 0 to about 99; and nn is from about 1 to about 99. 87. The proteinaceous substrate according to claim 71, wherein n 8 is from about 0 to about 99; n 9 is from about 1 to about 99; n 10 is from about 1 to about 99; and n is from about 0 to about 99. 88. The proteinaceous substrate according to claim 71 , wherein the proteinaceous substrate is selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails. 89. The proteinaceous substrate according to claim 71 , wherein the imido compound is cross-linked with a multifunctional nucleophilic agent. 90. The proteinaceous substrate according to claim 89, wherein the multifunctional nucleophilic agent is selected from the group consisting of 1 , 6-hexamethylenediamine, polyethyleneimines, polyalkoxides, and polythiols. 91. The proteinaceous substrate according to claim 71 , wherein the water-solubilizing/dispersing moiety bears an ionic charge and is electrostatically bound to a moiety bearing the opposite charge. 92. The proteinaceous substrate according to claim 91 , wherein the moiety bearing the opposite charge is selected from the group consisting of antimicrobials, ultraviolet chromophores, anionic dyes, anti-oxidants, fluorescing agents, brightening agents, shine and gloss enhancers, softening agents, and conditioning agents. 93. An imido compound represented by Formula (3): (3) wherein Wi is a water-solubilizing/dispersing moiety that provides water- solubility and/or water-dispersibility to the imido compound; R 3 is selected from the group consisting of hydrogen, C Cι 2 branched and unbranched alkyl, aryl, aralkyl, and alkaryl; Y is the residue of an ethylenically unsaturated hydrophilic monomer that provides water-solubility and/or water-dispersibility to the imido compound; Z is the residue of an ethylenically unsaturated monomer that provides structural units to the imido compound; the molecular weight of the imido compound is from about 300 to about 2,000,000; n 8 is from about 0 to about 100; n 9 is from about 0 to about 99; nι 0 is from about 0 to about 99; and nn is from about 0 to about 99; with the proviso that when n 8 is zero, n 9 and n 10 are not zero. 94. The imido compound according to claim 93, wherein W, is a hydrophilic group selected from the group consisting of anionic, cationic, zwitterioinc, and polar non-ionic functional groups. 95. The imido compound according to claim 94, wherein W, is selected from the group consisting of: (1) saccharides or polysaccharides wherein the number of units in the polysaccharide ranges from 1 to about 51 ; (2) quaternary ammonium salts represented by the formula, [(CH 2 ) n3 N + (CH 3 ) 3 ][A " ], wherein n 3 is an integer from 1 to about 10 and A is a monovalent anion; (3) alcohols represented by the formula, (CH 2 ) n OH, wherein n is an integer from 2 to about 10; (4) polyalkoxylated alcohols represented by the formula, -CH(CH 3 )CH 2 -(OCHR 2 CH 2 )n 5 -OCH 3 , wherein R 2 may be hydrogen or methyl, and n 5 is an integer from 0 to about 50; and (5) [-(CH 2 ) 3 N + (CH 3 ) 2 CH 2 COONa][A-], [-(CH 2 ) 3 N + (CH 3 ) 2 CH 2 CH 2 CH 2 SO 3 Na][A- ], -(CH 3 )(CH 2 ) 2 SO 3 Na, and -(CH 2 ) 2 SO 3 Na, wherein A is a monovalent anion. 96. The imido compound according to claim 93, wherein R 3 is a Cι-C 4 branched or unbranched alkyl group. 97. The imido compound according to claim 93, wherein Y is selected from the group consisting of anionic, cationic, zwitterionic, and nonionic monomers. 98. The imido compound according to claim 97, wherein Y is selected from the group of anionic monomers consisting of (meth)acrylic acid, crotonic acid, maleic acid, fumaric acid, itaconic acid, maleic anhydride, fumaric anhydride, itaconic anhydride, methyl hydrogen fumarate, butyl hydrogen fumarate, ethyl hydrogen maleate, butyl hydrogen maleate, allyloxy-benzene- sulfonate monomers, methallylsulfonate, styrene sulfonic acid, acrylamido alkyl sulfonates, aryl sulfonates, vinyl sulfonic acid, vinyl phosphonic acid, and the alkali, alkaline earth, and ammonium salts thereof. 99. The imido compound according to claim 97, wherein Y is selected from the group of cationic monomers consisting of (3-acrylamidopropyl) trimethylammonium chloride, [2-(acryloyloxy)ethyl] trimethylammonium methyl sulfate, 2-(dimethylamino) ethyl acrylate, [3- (methacryloylamino)propyl] trimethylammonium chloride, [2- (methacryloyloxy)ethyl] trimethylammonium chloride, [2- (methacryloyloxy)ethyl] trimethylammonium methyl sulfate, 2- (dimethylamino)ethyl methacrylate, 2-aminoethyl methacrylate hydrochloride, diallyl-dimethyl-ammonium chloride, vinyl imidazole, vinyl pyridine including substituted derivatives thereof, and quatemized vinyl pyridine. 100. The imido compound according to claim 97, wherein Y is selected from the group of zwitterionic monomers consisting of unsaturated carboxyl, sulfoxyl, and sulfate-substituted amines. 101. The imido compound according to claim 97, wherein Y is selected from the group of nonionic monomers consisting of C 1-4 hydroxy alkyl esters of (meth)acrylic acid, vinyl formamide, vinyl acetamide, 1-vinyl-2- pyrrolidinone, methacrylamide, acrylamide, C 1-4 mono- and dialkyl substituted (meth)acrylamides, acrylonitrile, methacrylonitrile, and polymerizable saccharide-derived monomers. 102. The imido compound according to claim 97, wherein Y is the residue of an ethylenically unsaturated hydrophilic vinyl alcohol monomer. 103. The imido compound according to claim 97, wherein Y is selected from the group consisting of [3-(methacryloylamino)propyl] trimethylammonium chloride, diallyl-dimethyl-ammonium chloride, methacrylic acid, acrylic acid, 2-acrylamido-2-methyl propane sulfonic acid, polymerizable saccharide-derived monomers, and the alkali, alkaline earth, and ammonium salts thereof. 104. The imido compound according to claim 93, wherein Z is selected from the group consisting of esters and amides of acrylic acid and methacrylic acid, vinyl aromatic compounds, vinyl esters, vinyl amides, vinyl ethers, ethylenically unsaturated nitriles, 1-butene, 1 ,3,butadiene, and substituted derivatives thereof. 105. The imido compound according to claim 104, wherein Z is selected from the group consisting of C 1-4 alkyl esters of acrylic acid and methacrylic acid, vinyl ethers, vinyl esters, and styrene. 106. The imido compound according to claim 93, wherein the molecular weight of the imido compound is from about 300 to about 5,000. 107. The imido compound according to claim 93, wherein the molecular weight of the imido compound is greater than about 5,000. 108. The imido compound according to claim 93, wherein n 8 is from about 1 to about 99; n 9 is from about 0 to about 99; n 0 is from about 0 to about 99; and nn is from about 1 to about 99. 109. The imido compound according to claim 93, wherein n 8 is from about 0 to about 99; n 9 is from about 1 to about 99; nι 0 is from about 1 to about 99; and nn is from about 0 to about 99. 110. A method for treating a proteinaceous substrate which comprises the steps of: (a) contacting a proteinaceous substrate with an aqueous solution of an imido compound at a pH value between about 4 and about 7 for a time sufficient to allow the imido compound to be adsorbed/absorbed on or into the proteinaceous substrate; and (b) raising the pH value of the imido compound adsorbed/absorbed on or into the proteinaceous substrate above about 7 for a time sufficient to allow the imido compound to react with the proteinaceous substrate; wherein the imido compound is represented by Formula (4): (4) wherein R 4 is independently selected from the group consisting of hydrogen, C Ci 2 branched and unbranched alkyl, aryl, aralkyl, and alkaryl; n 5 is 1 or 2, or both; R 5 and R 6 are independently selected from the group consisting of hydrogen, C Cι 2 branched and unbranched alkyl, aryl, aralkyl, and alkaryl, or together are -CH=CHCH=CH-; R 7 is independently selected from the group consisting of hydrogen, C Cι 2 branched and unbranched alkyl, aryl, aralkyl, alkaryl, and -CH 2 CH 2 CH 2 (OCH 2 CH 2 ) n16 CH 2 OH, wherein n 16 is from 1 to about 100; L, is a divalent linking group selected from the group consisting of alkylene, oxyalkylene, polyoxyalkylene, iminoalkylene, polyiminoalkylene, phenylene, and alkylene phenylene; the molecular weight of the imido compound is from about 300 to about 2,000,000; n 12 is from about 0 to about 100; n 13 is from about 0 to about 99; and n 14 is from about 0 to about 99; with the proviso that when nι 2 is zero, nι 3 is not zero. 111. The method according to claim 110, wherein R 4 is hydrogen. 112. The method according to claim 110, wherein nι 5 is 1. 113. The method according to claim 110, wherein R 5 and R 6 are both hydrogen or together are -CH=CHCH=CH-. 114. The method according to claim 110, wherein R 7 is independently selected from the group consisting of methyl, phenyl, and -CH 2 CH 2 CH 2 (OCH 2 CH 2 )ni 6 CH 2 OH, wherein n 16 is from 1 to about 100. 115. The method according to claim 110, wherein is an alkylene group having from 1 to 12 carbon atoms or -CH 2 CH 2 CH 2 (OCH 2 CH 2 ) n i 7 CH 2 -, wherein n 17 is from 1 to about 100. 116. The method according to claim 110, wherein the molecular weight of the imido compound is from about 300 to about 5,000. 117. The method according to claim 110, wherein the molecular weight of the imido compound is greater than about 5,000. 118. The method according to claim 110, wherein n 12 is from about 1 to about 99; n 13 is from about 0 to about 99; and n M is from about 0 to about 99. 119. The method according to claim 110, wherein n 12 is from about 0 to about 99; n 3 is from about 1 to about 99; and n 1 is from about 0 to about 99. 120. The method according to claim 110, wherein the proteinaceous substrate is selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails. 121. The method according to claim 110, wherein the imido compound is cross-linked with a multifunctional nucleophilic agent. 122. The method according to claim 121, wherein the multifunctional nucleophilic agent is selected from the group consisting of 1, 6- hexamethylenediamine, polyethyleneimines, polyalkoxides, and polythiols. 123. The method according to claim 110, wherein the imido compound bears an ionic charge and is electrostatically bound to a moiety bearing the opposite charge. 124. The method according to claim 123, wherein the moiety bearing the opposite charge is selected from the group consisting of antimicrobials, ultraviolet chromophores, anionic dyes, anti-oxidants, fluorescing agents, brightening agents, shine and gloss enhancers, softening agents, and conditioning agents. 125. The method according to claim 110, wherein the pH value of the imido compound adsorbed/absorbed on or into the proteinaceous substrate in step (b) is raised above about 7 employing a solvent in which the imido compound is substantially insoluble. 126. The method according to claim 125, wherein the solvent employed is selected from the group consisting of water, aqueous mixtures of C -C 3 alcohols, and mixtures thereof. 127. A proteinaceous substrate, having an imido compound covalently bonded to a portion thereof, wherein the imido compound is derived from a residue represented by Formula (4): (4) wherein R 4 is independently selected from the group consisting of hydrogen, C C 12 branched and unbranched alkyl, aryl, aralkyl, and alkaryl; n 15 is 1 or 2, or both; R 5 and R 6 are independently selected from the group consisting of hydrogen, C Cι 2 branched and unbranched alkyl, aryl, aralkyl, and alkaryl, or together are -CH=CHCH=CH-; R 7 is independently selected from the group consisting of hydrogen, CrC 12 branched and unbranched alkyl, aryl, aralkyl, alkaryl, and -CH 2 CH 2 CH 2 (OCH 2 CH 2 )ni 6 CH 2 OH, wherein n i6 is from 1 to about 100; Li is a divalent linking group selected from the group consisting of alkylene, oxyalkylene, polyoxyalkylene, iminoalkylene, polyiminoalkylene, phenylene, and alkylene phenylene; the molecular weight of the imido compound is from about 300 to about 2,000,000; n 12 is from about 0 to about 100; nι 3 is from about 0 to about 99; and n, is from about 0 to about 99; with the proviso that when n 12 is zero, n 13 is not zero. 128. The proteinaceous substrate according to claim 127, wherein R 4 is hydrogen. 129. The proteinaceous substrate according to claim 127, wherein n 15 is 1. 130. The proteinaceous substrate according to claim 127, wherein R 5 and R 6 are both hydrogen or together are -CH=CHCH=CH-. 131. The proteinaceous substrate according to claim 127, wherein R 7 is independently selected from the group consisting of methyl, phenyl, and -CH 2 CH 2 CH 2 (OCH 2 CH 2 ) n ι 6 CH 2 OH, wherein n 16 is from 1 to about 100. 132. The proteinaceous substrate according to claim 127, wherein L, is an alkylene group having from 1 to 12 carbon atoms or -CH 2 CH 2 CH 2 (OCH 2 CH 2 ) n17 CH2-, wherein n 17 is from 1 to about 100. 133. The proteinaceous substrate according to claim 127, wherein the molecular weight of the imido compound is from about 300 to about 5,000. 134. The proteinaceous substrate according to claim 127, wherein the molecular weight of the imido compound is greater than about 5000. 135. The proteinaceous substrate according to claim 127, wherein n 12 is from about 1 to about 99; n 3 is from about 0 to about 99; and nι 4 is from about 0 to about 99. 136. The proteinaceous substrate according to claim 127, wherein n, 2 is from about 0 to about 99; n 13 is from about 1 to about 99; and n M is from about 0 to about 99. 137. The proteinaceous substrate according to claim 127, wherein the proteinaceous substrate is selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails. 138. The proteinaceous substrate according to claim 127, wherein the imido compound is cross-linked with a multifunctional nucleophilic agent. 139. The proteinaceous substrate according to claim 138, wherein the multifunctional nucleophilic agent is selected from the group consisting of 1 , 6-hexamethylenediamine, polyethyleneimines, polyalkoxides, and polythiols. 140. The proteinaceous substrate according to claim 127, wherein the imido compound bears an ionic charge and is electrostatically bound to a moiety bearing the opposite charge. 141. The proteinaceous substrate according to claim 140, wherein the moiety bearing the opposite charge is selected from the group consisting of antimicrobials, ultraviolet chromophores, anionic dyes, anti-oxidants, fluorescing agents, brightening agents, shine and gloss enhancers, softening agents, and conditioning agents. 142. An imido compound represented by Formula (4): (4) wherein R 4 is independently selected from the group consisting of hydrogen, C C 12 branched and unbranched alkyl, aryl, aralkyl, and alkaryl; n 15 is 1 or 2, or both; R 5 and R 6 are independently selected from the group consisting of hydrogen, Cι-Cι 2 branched and unbranched alkyl, aryl, aralkyl, and alkaryl, or together are -CH=CHCH=CH-; R 7 is independently selected from the group consisting of hydrogen, C Cι 2 branched and unbranched alkyl, aryl, aralkyl, alkaryl, and -CH 2 CH 2 CH 2 (OCH 2 CH 2 ) n16 CH 2 OH, wherein n 16 is from 1 to about 100; Li is a divalent linking group selected from the group consisting of alkylene, oxyalkylene, polyoxyalkylene, iminoalkylene, polyiminoalkylene, phenylene, and alkylene phenylene; the molecular weight of the imido compound is from about 300 to about 2,000,000; nι 2 is from about 0 to about 100; nι 3 is from about 0 to about 99; and n 14 is from about 0 to about 99; with the proviso that when nι 2 is zero, nι 3 is not zero. 143. The imido compound according to claim 142, wherein R 4 is hydrogen. 144. The imido compound according to claim 142, wherein n i5 is 1. 145. The imido compound according to claim 142, wherein R 5 and R 6 are both hydrogen or together are -CH=CHCH=CH-. 146. The imido compound according to claim 142, wherein R 7 is independently selected from the group consisting of methyl, phenyl, and -CH 2 CH 2 CH 2 (OCH 2 CH 2 ) n i6CH 2 OH, wherein n i6 is from 1 to about 100. 147. The imido compound according to claim 142, wherein L, is an alkylene group having from 1 to 12 carbon atoms or -CH 2 CH 2 CH 2 (OCH 2 CH 2 ) n i7CH 2 -, wherein n 7 is from 1 to about 100. 148. The imido compound according to claim 142, wherein the molecular weight of the imido compound is from about 300 to about 5,000. 149. The imido compound according to claim 142, wherein the molecular weight of the imido compound is greater than about 5,000. 150. The imido compound according to claim 142, wherein nι 2 is from about 1 to about 99; n 13 is from about 0 to about 99; and nι is from about 0 to about 99. 151. The imido compound according to claim 142, wherein n 2 is from about 0 to about 99; n 13 is from about 1 to about 99; and nι 4 is from about 0 to about 99. 152. A method for treating a proteinaceous substrate which comprises the steps of: (a) contacting a proteinaceous substrate with an aqueous solution of an imido compound at a pH value between about 4 and about 7 for a time sufficient to allow the imido compound to be adsorbed/absorbed on or into the proteinaceous substrate; and (b) raising the pH value of the imido compound adsorbed/absorbed on or into the proteinaceous substrate above about 7 for a time sufficient to allow the imido compound to react with the proteinaceous substrate; wherein the imido compound is selected from the group consisting of succinimide/glutimde compounds represented by Formula (5): 0=C— N— C=0 I ( jr- O— )msSacch (5) maleimide compounds represented by Formula (6); -CH = CH — R 10 0=C— N— C=0 I (L 2 — O— )m 8 Sacch (6) and copolymers of the succinimide/glutimde compounds represented by Formula (6) with the maleimide compounds represented by Formula (6); wherein R 8 is independently selected from the group consisting of hydrogen, C 1 -C 12 branched and unbranched alkyl, aryl, aralkyl, and alkaryl; n 15 is 1 or 2, or both; L 2 is a divalent linking group selected from the group consisting of alkylene, hydroxy substituted alkylene, oxyalkylene, polyoxyalkylene, iminoalkylene, polyiminoalkylene, phenylene, and alkylene phenylene; nι 8 is 0 or 1 ; Sacch- represents a polysaccharide molecule; R 9 and Rio are independently selected from the group consisting of hydrogen, C Cι 2 branched and unbranched alkyl, aryl, aralkyl, and alkaryl, or together are -CH=CHCH=CH-; the molecular weight of the imido compound is from about 300 to about 2,000,000. 153. The method according to claim 152, wherein R 8 is hydrogen. 154. The method according to claim 152, wherein nι 5 is 1. 155. The method according to claim 152, wherein L 2 is selected from the group consisting of alkylene, hydroxy substituted alkylene, oxyalkylene, and polyoxyalkylene. 156. The method according to claim 152, wherein n 18 is 1. 157. The method according to claim 152, wherein the Sacch- group is selected from the group consisting of starch, gum, cellulose, and chitosan, and the cationic derivatives thereof. 158. The method according to claim 152, wherein R 9 and R 0 together are -CH=CHCH=CH-. 159. The method according to claim 152, wherein the imido compound comprises at least two imido groups per polysaccharide molecule. 160. The method according to claim 152, wherein the molecular weight of the imido compound is from about 300 to about 5,000. 161. The method according to claim 152, wherein the molecular weight of the imido compound is greater than about 5,000. 162. The method according to claim 152, wherein the imido compound is a succinimide represented by Formula (5). 163. The method according to claim 152, wherein the imido compound is a glutimide represented by Formula (6). 164. The method according to claim 152, wherein the imido compound is a copolymer of the succinimide represented by Formula (5) with the glutimide represented by Formula (6). 165. The method according to claim 152, wherein the proteinaceous substrate is selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails. 166. The method according to claim 152, wherein the imido compound is cross-linked with a multifunctional nucleophilic agent. 167. The method according to claim 166, wherein the multifunctional nucleophilic agent is selected from the group consisting of 1, 6- hexamethylenediamine, polyethyleneimines, polyalkoxides, and polythiols. 168. The method according to claim 152, wherein the imido compound bears an ionic charge and is electrostatically bound to a moiety bearing the opposite charge. 169. The method according to claim 168, wherein the moiety bearing the opposite charge is selected from the group consisting of antimicrobials, ultraviolet chromophores, anionic dyes, anti-oxidants, fluorescing agents, brightening agents, shine and gloss enhancers, softening agents, and conditioning agents. 170. The method according to claim 152, wherein the pH value of the imido compound adsorbed/absorbed on or into the proteinaceous substrate in step (b) is raised above about 7 employing a solvent in which the imido compound is substantially insoluble. 171. The method according to claim 170, wherein the solvent employed is selected from the group consisting of C 2 -C 3 alcohols, aqueous mixtures of C -C 3 alcohols, and mixtures thereof. 172. A proteinaceous substrate, having an imido compound covalently bonded to a portion thereof, wherein the imido compound is selected from the group consisting of succinimide/glutimde compounds represented by Formula (5): 0=C— N— C=0 I (Lz— O— )ni 8 Sacch (5) maleimide compounds represented by Formula (6); -CH = CH — R 10 0= C=0 I (L ∑ — O— )ni 8 Sacch (6) and copolymers of the succinimide/glutimde compounds represented by Formula (6) with the maleimide compounds represented by Formula (6); wherein R 8 is independently selected from the group consisting of hydrogen, CrC 12 branched and unbranched alkyl, aryl, aralkyl, and alkaryl; nι 5 is 1 or 2, or both; L 2 is a divalent linking group selected from the group consisting of alkylene, hydroxy substituted alkylene, oxyalkylene, polyoxyalkylene, iminoalkylene, polyiminoalkylene, phenylene, and alkylene phenylene; nι 8 is 0 or 1 ; Sacch- represents a polysaccharide molecule; R 9 and Rι 0 are independently selected from the group consisting of hydrogen, C Cι 2 branched and unbranched alkyl, aryl, aralkyl, and alkaryl, or together are -CH=CHCH=CH-; the molecular weight of the imido compound is from about 300 to about 2,000,000. 173. The proteinaceous substrate according to claim 172, wherein R 8 is hydrogen. 174. The proteinaceous substrate according to claim 172, wherein n 15 is 1. 175. The proteinaceous substrate according to claim 172, wherein L 2 is selected from the group consisting of alkylene, hydroxy substituted alkylene, oxyalkylene, and polyoxyalkylene. 176. The proteinaceous substrate according to claim 172, wherein n i8 is 1. 177. The proteinaceous substrate according to claim 172, wherein the Sacch- group is selected from the group consisting of starch, gum, cellulose, and chitosan, and the cationic derivatives thereof. 178. The proteinaceous substrate according to claim 172, wherein R 9 and R 10 together are -CH=CHCH=CH-. 179. The proteinaceous substrate according to claim 172, wherein the imido compound comprises at least two imido groups per polysaccharide molecule. 180. The proteinaceous substrate according to claim 172, wherein the molecular weight of the imido compound is from about 300 to about 5,000. 181. The proteinaceous substrate according to claim 172, wherein the molecular weight of the imido compound is greater tha about 5,000. 182. The proteinaceous substrate according to claim 172, wherein the imido compound is a succinimide represented by Formula (5). 183. The proteinaceous substrate according to claim 172, wherein the imido compound is a glutimide represented by Formula (6). 184. The proteinaceous substrate according to claim 172, wherein the imido compound is a copolymer of the succinimide represented by Formula (5) with the glutimide represented by Formula (6). 185. The proteinaceous substrate according to claim 172, wherein the proteinaceous substrate is selected from the group consisting of hair, wool, skin, leather, silk, fur, felt, and nails. 186. The proteinaceous substrate according to claim 172, wherein the imido compound is cross-linked with a multifunctional nucleophilic agent. 187. The proteinaceous substrate according to claim 186, wherein the multifunctional nucleophilic agent is selected from the group consisting of 1 , 6-hexamethylenediamine, polyethyleneimines, polyalkoxides, and polythiols. 188. The proteinaceous substrate according to claim 172, wherein the imido compound bears an ionic charge and is electrostatically bound to a moiety bearing the opposite charge. 189. The proteinaceous substrate according to claim 188, wherein the moiety bearing the opposite charge is selected from the group consisting of antimicrobials, ultraviolet chromophores, anionic dyes, anti-oxidants, fluorescing agents, brightening agents, shine and gloss enhancers, softening agents, and conditioning agents. 190. An imido compound selected from the group consisting of succinimide/glutimde compounds represented by Formula (5): I (L 2 — O— )m 8 Sacch (5) maleimide compounds represented by Formula (6); 0=C— M— C=0 I ( -z— O— ) n18 Sacch (6) and copolymers of the succinimide/glutimde compounds represented by Formula (6) with the maleimide compounds represented by Formula (6); wherein R 8 is independently selected from the group consisting of hydrogen, Cι-C 12 branched and unbranched alkyl, aryl, aralkyl, and alkaryl; nι 5 is 1 or 2, or both; L 2 is a divalent linking group selected from the group consisting of alkylene, hydroxy substituted alkylene, oxyalkylene, polyoxyalkylene, iminoalkylene, polyiminoalkylene, phenylene, and alkylene phenylene; n 18 is 0 or 1 ; Sacch- represents a polysaccharide molecule; R 9 and R 10 are independently selected from the group consisting of hydrogen, Cι-Cι 2 branched and unbranched alkyl, aryl, aralkyl, and alkaryl, or together are -CH=CHCH=CH-; the molecular weight of the imido compound is from about 300 to about 2,000,000. 191. The imido compound according to claim 190, wherein R 8 is hydrogen. 192. The imido compound according to claim 190, wherein nι 5 is 1. 193. The imido compound according to claim 190, wherein L 2 is selected from the group consisting of alkylene, hydroxy substituted alkylene, oxyalkylene, and polyoxyalkylene. 194. The imido compound according to claim 190, wherein n 18 is 1. 195. The imido compound according to claim 190, wherein the Sacch- group is selected from the group consisting of starch, gum, and cellulose, and the cationic derivatives thereof. 196. The imido compound according to claim 190, wherein R 9 and Rio together are -CH=CHCH=CH-. 197. The imido compound according to claim 190, wherein the imido compound comprises at least two imido groups per polysaccharide molecule. 198. The imido compound according to claim 190, wherein the molecular weight of the imido compound is from about 300 to about 5,000. 199. The imido compound according to claim 190, wherein the molecular weight of the imido compound is greater than about 5,000. 200. The imido compound according to claim 190, wherein the imido compound is a succinimide represented by Formula (5). 201. The imido compound according to claim 190, wherein the imido compound is a glutimide represented by Formula (6). 202. The imido compound according to claim 190, wherein the imido compound is a copolymer of the succinimide represented by Formula (5) with the glutimide represented by Formula (6). 203. The imido compound according to claim 95, wherein W, is selected from the group consisting of hydroxyalkyls, polyhydroxyalkyls, and saccharides. 204. The imido compound according to claim 99, wherein Y is [3- (methacryloylamino)propyl] trimethylammonium chloride. 205. The imido compound according to claim 103, wherein Y is a polymerizable saccharide-derived monomer, or an alkali, alkaline earth, or ammonium salt thereof. 206. The imido compound according to claim 145, wherein R 5 and R 6 are both hydrogen. 207. The imido compound according to claim 190, wherein n 18 is 1 , L 2 is -CH 2 CHOHCH 2 -, and R 9 and Rι 0 together are -CH=CHCH=CH-. 208. The imido compound according to claim 190, wherein nι 8 is 1 , L 2 is -CH 2 CHOHCH 2 -, n 15 is 1 , and R 8 is hydrogen.

Inventors: GUTH JACOB J, IOVINE CARMINE, JOSEPH DAVID, PETERSEN PAUL M, SAVOCA ANN C, THOMAIDES JOHN S, VONA SAMUAL A JR, WANG FANG, GUTH, JACOB, J., IOVINE, CARMINE, JOSEPH, DAVID, PETERSEN, PAUL, M., SAVOCA, ANN, C., THOMAIDES, JOHN, S., VONA, SAMUAL, A., JR., WANG, FANG
Applicants: GUTH JACOB J, IOVINE CARMINE, JOSEPH DAVID, NAT STARCH & CHEMICAL COMPANY, PETERSEN PAUL M, SAVOCA ANN C, THOMAIDES JOHN S, VONA SAMUAL A JR, WANG FANG, GUTH, JACOB, J., IOVINE, CARMINE, JOSEPH, DAVID, NATIONAL STARCH & CHEMICAL COMPANY, PETERSEN, PAUL, M., SAVOCA, ANN, C., THOMAIDES, JOHN, S., VONA, SAMUAL, A., JR., WANG, FANG
Application year: 1999
Main classification: A61K
IPC codes: A61K9, A61K31, C07D207