ARYL SUBSTITUTED OLEFINIC AMINES AND THEIR USE AS CHOLINERGIC RECEPTORS AGONISTS

Abstract: Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5- (3-pyridyl) -4-penten-2-amine, (4E) -N-methyl-5- (5-pyrimidinyl) -4-penten-2-amine, (4E)-N-methyl-5-( 5-methoxy-3-pyridyl) -4-penten-2-amine, (4E)-N- methyl-5- (6-amino-5-methyl -3-pyridyl)-4-penten -2-amine, (2R)-(4E) -N-methyl-5-(3-pyridyl) -4-penten-2-amine, (2R)-(4E)-N- methyl-5-(5- isopropoxy-3-pyridyl) -4-penten-2-amine, (4E)-N-methyl -5-(5-bromo-3-pyridyl) -4-penten-2-amine, (4E)-N-methyl -5-(5-ethoxy-3- pyridyl)-4-penten- 2-amine, (2S)-(4E)-N- methyl-5-(3-pyridyl) -4-penten-2-amine, (4E)-N-methyl -5-(5-isopropoxy-3- pyridyl)-4- penten-2-amine and (2S)-(4E)-N-methyl -5-(5-isopropoxy -3-pyridyl) -4-penten-2-amine.

Description: ARYL SUBSTITUTED OLEFINIC AMINES AND THEIR USE AS CHOLINERGIC RECEPTORS AGONISTS Background of the Invention The present invention relates to compounds capable of activating nicotinic cholmergic receptors, for example, as agonists of specific nicotinic receptor subtypes 5 Nicotine has been proposed to have a number of pharmacological effects See, for example, Pullan et al N Engl J Med 330 81 1-815 (1994) Certain of those effects may be related to effects upon neurotransmitter release See for example, Sjak-shie et al , Brain Res 624 295 (1993), where neuroprotective effects of nicotine are proposed Release of acetylcho ne and dopamine by neurons upon administration of nicotine has 10 been reported by Rowell et al , J Neurochem 43 1593 (1984), Rapier et al , J Neurochem 50 1123 (1988), Sandor et al , Brain Res 567 313 (1991) and Vizi, Br J Pharmacol 47 765 (1973) Release of norepinephπne by neurons upon administration of nicotine has been reported by Hall et al , Biochem Pharmacol 21 1829 (1972) Release of serotonin by neurons upon administration of nicotine has been reported by 15 Hery et al , Λi ch hit Pharmacodvn The> 296 91 (1977) Release of glutamate by neurons upon administration of nicotine has been reported by Toth et al , Neurochem Res 17 265 (1992) In addition, nicotine reportedly potentiates the pharmacological behavior of certain pharmaceutical compositions used for the treatment of certain disorders See, Sanberg et al , Pharmacol Biochem &_ Behavior 46 303 (1993), Harsmg 20 et al , J New ochem 59 48 (1993) and Hughes Pi oceedingsfrom Intl Sv p Λ/c S40 (1994) Furthermore, vaπous other beneficial pharmacological effects of nicotine have been proposed See, Decina et al , Biol Ps\ chιam 28 502 (1990), Wagner et al , Pharmacopsxchiatrv 21 301 (1988), Pomerleau et al , Addictive Behaviors 9 265 ( 1984), Onaivi et al . Life Sci 54(3) 193 (1994), Tnpathi et al , JPET 221 91-96 (1982) and _._> Hamon. Tiends in Pharmacol Res 15 36 Various nicotinic compounds have been reported as being useful for treating a wide variety of conditions and disorders. See, for example, Williams et al. DN&P 7(4):205-227 (1994), Arneπc et al . CNS Drug Rev. 1(1): 1 -26 ( 1995), Ameπc et al., Exp. Opin. Invest. Drugs 5(\):19- \ 00 ( 1996), Bencherif et al., JPET 219- 1413 ( 1996), Lφpiello et al., JPET 279: 1422 ( 1996), Damaj et al., Neuroscience ( 1997), Holladay et al., J. Med. Chem 40(28): 4169-4194 ( 1997), Bannon et al., Science 279- 77-80 (1998), PCT WO 94/08992, PCT WO 96G 1475, and U.S. Patent Nos. 5.583, 140 to Bencherif et al., 5,597,919 to Dull et al., 5,604.231 to Smith et al. and 5,616,716 to Dull et al. Nicotinic compounds are reported as being particularly useful for treating a wide variety of Central Nervous System (CNS) disorders. CNS disorders are a type of neurological disorder. CNS disorders can be drug induced; can be attπbuted to genetic predisposition, infection or trauma, or can be of unknown etiology. CNS disorders compπse neuropsychiatπc disorders, neurological diseases and mental illnesses; and include neurodegenerative diseases, behavioral disorders, cognitive disorders and cognitive affective disorders. There are several CNS disorders whose clinical manifestations have been attributed to CNS dysfunction (i.e., disorders resulting from inappropriate levels of neurotransmitter release, inappropriate properties of neurotransmitter receptors, and/or inappropπate interaction between neurotransmitters and neurotransmitter receptors). Several CNS disorders can be attributed to a cholinergic deficiency, a dopaminergic deficiency, an adrenergic deficiency and/or a serotonergic deficiency. CNS disorders of relatively common occurrence include presemle dementia (early onset Alzheimer ' s disease), senile dementia (dementia of the Alzheimer's type), Parkinsonism including Parkinson's disease, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania, attention deficit disorder, anxiety, dyslexia, schizophrenia and Tourette's syndrome. It would be desirable to provide a useful method for the prevention and treatment of a condition or disorder by administering a nicotinic compound to a patient susceptible to or suffering from such a condition or disorder. It would be highly beneficial to provide individuals suffering from certain disorders (e.g., CNS diseases) with interruption of the symptoms of those disorders by the administration of a pharmaceutical composition containing an active ingredient having nicotinic pharmacology and which has a beneficial effect (e.g., upon the functioning of the CNS), but which does not provide anv significant associated side effects It would be highly -2- SUBSTΓTLΠΈ SHEET (RULE 26) desirable to provide a pharmaceutical composition incorporating a compound which interacts with nicotinic receptors, such as those w hich have the potential to affect the functioning of the CNS, but which compound when employed in an amount sufficient to affect the functioning of the CNS, does not significantly affect those receptor subtypes which have the potential to induce undesirable side effects (e g , appreciable activity at skeletal muscle and ganglia sites) Summary of the Invention The present invention relates to aryl substituted olefimc amme compounds Representative compounds are (4E)-N-rnethyl-5-(3-pyπdyl)-4-penten-2-amιne, (4E)- N-methyl-5-(5-pyπmιdιnyl)-4-penten-2-amιne. (4E)-N-methyl-5-(5-methoxy-3- pyndyl)-4-penten-2-amme, (4E)-N-methyl-5-(6-amιno-5-methyl-3-pyπdyl)-4-penten- 2-amιne. (2R)-(4E)-N-methyl-5-(3-pyπdyl)-4-penten-2-amιne, (2R)-(4E)-N-methyl- 5-(5-ιsopropoxy-3-pyπdyl)-4-penten-2-amιne, (4E)-N-mefhyl-5-(5-bromo-3-pyπdyl)- 4-penten-2-amme, (4E)-N-methyl-5-(5-ethoxy-3-pyπdyl)-4-penten-2-amιne, (2S)- (4E)-N-methyl-5-(3-pyπdyl)-4-penten-2-amιne, (4E)-N-mefhyl-5-(5-ιsopropoxy-3- pyπdyl)-4-penten-2-amιne and (2S)-(4E)-N-methyl-5-(5-ιsopropoxy-3-pyπdyl)-4- penten-2-amιne The present invention also relates to methods for synthesizing certain aryl substituted olefmic amine compounds, such as the compounds of the present invention. Of particular interest are isolated enamiomeπc compounds (l e , compounds in a substantially pure form, as opposed to racemic mixtures), and methods for synthesizing such enaniomeπc compounds in substantially pure form The present invention also relates to methods for the prevention or treatment of a wide vaπety of conditions or disorders, and particularly those disorders characteπzed by dysfunction of nicotinic chohnergic neurotransmission including disorders involving neuromodulation of neurotransmitter release, such as dopamine release The present invention also relates to methods for the prevention or treatment of disorders, such as central nervous system (CNS) disorders, which are characteπzed by an alteration in normal neurotransmitter release The present invention also relates to methods for the treatment of certain conditions (e g , a method for alleviating pain) The methods invoh e administering to a subject an effective amount of a compound of the present invention -j - The present invention, in another aspect, relates to a pharmaceutical composition compπsing an effective amount of a compound of the present invention Such a pharmaceutical composition incorporates a compound which, when employed in effective amounts, has the capability of interacting with relevant nicotinic receptor sites of a subject, and hence has the capabiht\ of acting as a therapeutic agent in the prevention or treatment of a wide vaπety of conditions and disorders, particularly those disorders characteπzed by an alteration in normal neurotransmitter release. Preferred pharmaceutical compositions compπse compounds of the present invention. The pharmaceutical compositions of the present invention are useful for the prevention and treatment of disorders, such as CNS disorders, which are characteπzed by an alteration in normal neurotransmitter release The pharmaceutical compositions provide therapeutic benefit to individuals suffeπng from such disorders and exhibiting clinical manifestations of such disorders in that the compounds within those compositions, when employed in effective amounts, have the potential to (i) exhibit nicotinic pharmacology and affect relevant nicotinic receptors sites (e g , act as a pharmacological agonist to activate nicotinic receptors), and (n) elicit neurotransmitter secretion, and hence prevent and suppress the symptoms associated with those diseases In addition, the compounds are expected to have the potential to (I) increase the number of nicotinic chohnergic receptors of the brain of the patient, (n) exhibit neuroprotective effects and (in) when employed in effective amounts do not cause appreciable adverse side effects (e g , significant increases in blood pressure and heart rate, significant negative effects upon the gastro-intestinal tract, and significant effects upon skeletal muscle) The pharmaceutical compositions of the present invention are believed to be safe and effective with regards to prevention and treatment of a wide vaπety of conditions and disorders The foregoing and other aspects of the present invention are explained m detail in the detailed descπption and examples set forth below -4- SUBSTΓΠΠΈ SHEET (RULE 26) Detailed Description of the Invention The compounds of the present invention include compounds of the formula z. where each of X and X' are individually nitrogen or carbon bonded to a substituent species characteπzed as having a sigma m value greater than 0, often greater than 0.1, and generally greater than 0 2, and even greater than 0 3, less than 0 and generally 10 less than -0 1 , or 0; as determined in accordance with Hansch et al , Chem Rev 91.165 (1991), m is an integer and n is an integer such that the sum of m plus n is 1 , 2, 3, 4, 5, 6, 7, or 8, preferably is 1 , 2, or 3, and most preferably is 2 or 3, the wavy line in the structure indicates that the compound can have the cis (Z) or trans (E) form; E 1 , E 11 , E'", E !V , E and E ' individually represent hydrogen or lower alkyl (e.g , 15 straight chain or branched alkyl including Cι-C 8 , preferably such as methyl, ethyl, or isopropyl) or halo substituted lower alkyl (e.g , straight chain or branched alkyl including C C , preferably Ci -Cs, such as tnfluoromethyl or tπchloromethyl), and at least one of E 1 , E π , E 1 ", E IV , E V and E vι is non-hydrogen and the remaining E 1 , E 11 , E" 1 , E 1V , E V and E vι are hydrogen, and Z' and Z" individually represent hydrogen 0 or lower alkyl (e g., straight chain or branched alkyl including Cι-C 8 , preferably d- C 5 , such as methyl, ethyl, or isopropyl), and preferably at least one of Z' and Z" is hydrogen, and most preferably Z' is hydrogen and Z" is methyl, alternatively Z' is hydrogen and Z" represents a ring structure (cycloalkyl or aromatic), such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, adamantyl, 5 quinuclidmyl, pyπdyl, quinohnyl, pyπmidinyl, phenyl, benzyl (where any of the foregoing can be suitably substiuted with at least one substituent group, such as alkyl, halo, or amino substituents), alternatively Z', Z", and the associated nitrogen atom can form a ring structure such as aziπdinvl, azetidmyl, pyrol dinyl, pipeπdinyl, qumuchdinyl, piperazmyl. or morphohnyl More specifically, X and X ' include N, C- ^0 H. C-F, C-Cl. C-Br, C-I. C-R'. C-NR'R", C-C C-OH, C-CN, C-N0 2 . C-C..R', C- -5- SUBSTITLΠΈ SHEET (RULE 26) SH, C-SCHi, C-Ni, C-S0 2 CH 3 , C-OR', C-SR', C-C(=0)NR'R", C-NR'C(=0)R', C- C(=0)R\ C-C(=0)OR', C(CH 2 ) q OR\ C-OC(=0)R', COC(=0)NR'R" and C- NR'C(=0)OR' where R' and R" are individually hvdrogen or lower alkyl (e g , C| -Cιo alkyl, preferably Ci-Cs alkyl, and more preferably methyl, ethyl, isopropyl or isobutyl), an aromatic group-containing species or a substituted aromatic group- containing species, and q is an integer from 1 to 6 R' and R" can be straight chain or branched alkyl, or R' and R" can form a cycloalkvl funtionahty (e.g., cyclopropyl cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, adamantyl, and quinuchdinyl) Representative aromatic group-containing species include pyπdyl, quinohnyl, pyπmidmyl, phenyl, and benzyl (where any of the foregoing can be suitably substituted with at least one substituent group, such as alkyl, halo, or amino substituents) Other representative aromatic ring systems are set forth in Gibson et al , J Med Chem 39 4065 (1996) When X and X' represent a carbon atom bonded to a substituent species, that substituent species often has a sigma m value which is between about -0 3 and about 0.75, and frequently between about -0 25 and about 0 6 In certain circumstances the substituent species is characteπzed as having a sigma m value not equal to 0 A, A' and A" individually represent those species descπbed as substituent species to the aromatic carbon atom previously descπbed for X and X', and usually include hydrogen, halo (e.g , F, CI, Br, or I), alkyl (e.g., lower straight chain or branched Ci 8 alkyl, but preferably methvl or ethyl), or NX"X' " where X" and X" ' are individually hydrogen or lower alkvl, including Cι-C 8 , preferably Ci -C-, alkyl In addition, it is highly preferred that A is hvdrogen, it is preferred that A' is hydrogen, and normally A" is hydrogen Generally, both A and A' are hydrogen, sometimes A and A' are hydrogen, and A" is ammo, methyl or ethyl, and often A, A' and A" are all hydrogen In a preferred embodiment, m is 1 or 2, n is 1, E 1 , E 1 ', E 1 ", E IV and E ι each are hydrogen, and E v is alkyl (e g , methyl) Depending upon the identity and positioning of each individual E 1 , E , E 1 ', E , E and E , certain compounds can be optically active Additionally, compounds of the present invention can have chiral centers within the alkenyl side chain e g , the compound can have an R or S configuration depending on the selection of E 111 , E , E and E , with the S configuration being preferred Depending upon E . E , E , E , E and E , compounds of the present invention have chiral centers, and the present invention -6- SUBSTΓΠΠΈ SHEET (RULE 26) relates to racemic mixtures of such compounds as well as enamiomeπc compounds. Typically, the selection of m. n, E 1 , E 11 , E 1 ", E lv , E V and E vι is such that up to about 4, and frequently up to 3, and usually 1 or 2, of the substituents designated as E 1 , E 11 , E , E , E and E are non-hydrogen substituents (i.e., substituents such as lower alkyl or halo-substituted lower alkyl). Typically, X is CH, CBr or COR. Most preferably, X' is nitrogen. Of particular interest are compounds of the formula: where m, E 1 , E 11 , E 1 ", E ιv , X, Z\ Z", A, A' and A" are as defined hereinbefore. Representative compounds of the present invention are (3E) and (3Z)-N- methyl-4-(3-pyridyl)-2-methyl-3-buten-l -amine, (3E) and (3Z)-N-methyl-4-(3- pyridyl)-3-methyl-3-buten- l -amιne, (5E) and (5Z)-N-methyl-6-(3-pyndyl)-5-hexen-3- amine, (4E) and (4Z)-N-methyl-5-(3-pyridyl)-2-methyl-4-penten-2-amιne, (4E) and (4Z)-N-methyl-5-(3-pyridyl)-3- ethyl-4-penten-2-amine, (4E) and (4Z)-N-methyl-5- (3-pyridyl)-4-penten-2-amιne, (4E) and (4Z)-N-methyl-5-(3-pyπdyl)- 1 , 1 , 1 -trifluoro- 4-penten-2-amιne, (4E) and (4Z)-N-methyl-5-(3-pyridyl)-4-methyl-4-penten- l -amine, (4E) and (4Z)-N-methyl-5-(3-pyπdyl)-4-methyl-4-penten-2-amιne, ( IE) and (1Z)-N- methyl- 1 -(3-pyridyl)- l -octen-4-amιne, ( IE) and (lZ)-N-methyl-l -(3-pyπdyl)-5- methyl-l-hepten-4-amιne, (5E) and (5Z)-N-methyl-6-(3-pyπdyl)-5-methyl-5-hexen-2- amine, (5E) and (5Z)-N-methyl-6-(3-pyridyl)-5-hexen-2-amine, (5E) and (5Z)-N- methyl-6-(3-pyridyl)-5-methyl-5-hexen-3-amιne, (3E) and (3Z)-4-(3-pyπdyl)-2- methyl-3-buten-l -amine, (3E) and (3Z)-4-(3-pyridyl)-3-methyl-3-buten- l -amine, (5E) and (5Z)-6-(3-pyridyl)-5-hexen-3-amιne, (4E) and (4Z)-5-(3-pyπdyl)-2-ιnethyl-4- penten-2-amine, (4E) and (4Z)-5-(3-pyπdyl)-3-methyl-4-penten-2-amιne, (4E) and (4Z)-5-(3-pyndyl)-4-penten-2-amιne, (4E) and (4Z)-5-(3-pyπdyl)- 1.1.1 -tπfluoro-4- penten-2-amιne, (4E) and (4Z)-5-(3-pyπdyl)-4-methyl-4-penten- l -amιne, (4E) and (4Z)-5-(3-pyridyl)-4-methyl-4-penten-2-amιne, (I E) and (lZ)-l -(3-pyπdyl)-l-octen- 4-amιne, (5E) and (5Z)-6-(3-pyπdyl)-5-methyl-5-hexen-2-amιne. ( 5E) and (5Z)-6-(3- pyπdyl)-5-hexen-2-amιne, and (5E) and (5Z)-6-(3-pvπdyl)-5-methyl-5-hexen-3- amine See. L S Patent No 5,616,716 to Dull et al The manner in which aryl substituted olefinic amine compounds of the present invention are synthetically produced can vary (E)-metamcotine-type compounds can be prepared using the techniques set forth bv Loffler et al , Chem Ber , 42, pp 3431- 3438 ( 1909) and Laforge, J A C S , 50, p 2477 ( 1928) from substituted nicotine-type compounds Certain 6-substιtuted metanicotme-tvpe compounds can be prepared from the corresponding 6-substιtuted nicotme-type compounds using the general methods of Acheson et al , J Chem Soc . Perkin Trans 1. 2, pp 579-585 (1980) The requisite precursors for such compounds, 6-substιtuted nicotine-type compounds, can be synthesized from 6-substιtuted nicotinic acid esters using the general methods disclosed bv Rondahl, Acta Pharm Suec , 14, pp 1 13-1 18 (1977) Preparation of certain 5 -substituted metamcotine-type compounds can be accomplished from the corresponding 5-substιtuted nicotine-type compounds using the general method taught by Acheson et al , J Chem Soc . Perkin Trans 1. 2, pp 579-585 (1980) The 5-halo- substituted nicotine-type compounds (e g , fluoro- and bromo-substituted mcotine- type compounds) and the 5-amιno nicotine-type compounds can be prepared using the general procedures disclosed by Rondahl, Act Pharm Suec , 14, pp 1 13-1 18 ( 1977) The 5-tπfluoromethyl nicotine-type compounds can be prepared using the techniques and mateπals set forth in Ashimoπ et al , Chem Pharm Bull , 38(9), pp. 2446-2458 (1990) and Rondahl, Acta Pharm. Suec , 14, pp 1 13-1 18 (1977) Furthermore, preparation of certain metamcotine-type compounds can be accomplished using a palladium catalyzed coupling reaction of an aromatic halide and a terminal olefin containing a protected amine substituent, removal of the protective group to obtain a pπmary amme, and optional alkvlation to provide a secondary or tertiary amine In particular, certain metamcotine-type compounds can be prepared by subjecting a 3-halo-substιtuted, 5-substιtuted pvπdine compound or a 5-halo- substituted pyπmidine compound to a palladium catalyzed coupling reaction using an olefin possessing a protected amine functionality (e , such an olefin provided by the reaction of a phthahmide salt with 3-halo- l -propene, 4-halo-l -butene, 5-halo- l - pentene or 6-halo- 1 -hexene) See, Frank et al , J Oi g Chem , 43(15), pp 2947- 2949 (1978) and Malek et al , J Org Chem , 47, pp 5395-5397 ( 1982) Alternatively . certain metamcotine-type compounds can be prepared by coupling an -S- N-protected. modified amino acid residue, such as 4-(N-methyl-N-tert- butyloxycarbonyl)amιnobutyrιc acid methyl ester, with an aryl lithium compound, as can be deπved from a suitable arvl halide and butyl lithium The resulting N- protected aryl ketone is then chemically reduced to the corresponding alcohol, converted to the alkyl halide. and subsequently dehydrohalogenated to introduce the olefin functionality Removal of the N-protecting group then affords the desired metamcotine-type compound There are a number of different methods for providing (Z)-metanιcotme-type compounds. In one method, (Z)-metanιcotme-type compounds can be synthesized from nicotine-type compounds as a mixture of E and Z isomers; and the (Z)- metanicotine-type compounds can then be separated by chromatography using the types of techniques disclosed by Sprouse et al , Abstracts of Papers, p. 32, Coresta/TCRC Joint Conference { 1972) In another method, metamcotine-type compounds can be prepared by the controlled hydrogenation of the corresponding acetylemc compound (e.g., an N-methyl-4-(3-pyndιnyl)-3-butyn-l-amme type compound). For example, certain 5 -substituted (Z)-metanιcotιne-type compounds and certain 6-substιtuted (Z)-metanιcotιne-type compounds can be prepared from 5- substιtuted-3-pyπdmecarboxaldehydes and 6-substιtuted-3-pyπdιnecarboxaldehydes, respectively. Representative synthetic techniques for (Z)-metanιcotιne-type compounds are set forth in U S. Patent No 5,597,919 to Dull et al There are a number of methods by which the (Z)-olefinιc isomers of aryl substituted olefinic amine compounds can be synthetically produced. In one approach, the (Z)-ιsomers of aryl substituted olefinic amine compounds can be prepared by the controlled hydrogenation of the corresponding alkynyl compounds (e.g., a N-mefhyl- 5-(3-pyπdyl)-4-butyn-2-amιne-type compound) using commercially available Lindlar catalyst (Aldπch Chemical Company) using the methodology set forth in H. Lindlar et al , Org Syn. 46: 89 (1966) The requisite alkynyl compounds can be prepared by the palladium catalyzed coupling of an aromatic halide, preferably a 3- bromopyπdine-type or a 3-ιodopyπdιne-type compound with an alkynyl side chain compound (e.g., an N-methyl-4-pentyn-2-amιne-type compound) Typically the methodolgy set forth in L. Bleicner et al.. Sxnletl 1 1 15 (1995) is used for the palladium catalyzed coupling of an aryl halide with a monosubstituted alkyne in the presence of copper(I) iodide and tπphenylphosphine and potassium carbonate as a -9- SUBSTΓΠΠΈ SHEET (RULE 26) base Alkynyl compounds such as N-methvl-4-pentyn-2-amιne can be prepared from commercially available 4-pentyn-2-ol (Aldπch Chemical Company) by treatment with p-toluenesulfonyl chloπde in pyπdine. followed by reaction of the resulting 4-pentyn- 2-ol p-toluenesulfonate with excess methylamine either as a 40% aqueous solution or as a 2 0 M solution in tetrahydrofuran In some instances it may be necessary to protect the amino functionality of the N-methyl-4-pentyn-2-amιne-type compound by treatment with di-tert-butyl dicarbonate to give the tert-butoxycarbonyl protected amine-type compound. Such protected amine compounds may undergo the palladium catalyzed coupling with aryl hahdes and the subsequent controlled hydrogenation of the resulting alkynyl compound more easily than the unprotected amine compounds The tert-butoxycarbonyl protecting group can be easily removed using a strong acid such as tπfluoroacetic acid to yield the (Z)-olefinιc isomers of aryl substituted olefinic amine compounds The methods by which aryl substituted olefinic amine compounds of the present invention can be synthetically produced can vary An olefinic alcohol, such as 4-penten-2-ol, is condensed with an aromatic halide, such as 3-bromopyπdιne or 3- lodopyπdine Typically, the types of procedures set forth in Frank et al , J Org Chem , 43, pp. 2947-2949 (1978) and Malek et al., J Org Chem , 47, pp. 5395-5397 ( 1982) involving a palladium-catalyzed coupling of an olefin and an aromatic halide are used. The olefinic alcohol optionally can be protected as a t-butyldimethylsilyl ether pπor to the coupling Desilylation then produces the olefinic alcohol The alcohol condensation product then is converted to an amine using the type of procedures set forth in deCosta et al , J Ore Chem , 35, pp 4334-4343 ( 1992) Typically, the alcohol condensation product is converted to the aryl substituted olefinic amine by activation of the alcohol using methanesulfonyl chloπde or p- toluenesulfonyl chloπde, followed by mesylate or tosylate displacement using ammonia, or a pπmary or secondary amine Thus, when the amine is ammonia, an aryl substituted olefinic pπmary amine compound is provided, when the amine is a primary amine such as methylamine or cyclobutylamine, an aryl substituted olefinic secondary amine compound is provided, and when the amine is a secondary amine such as dimethylamine or pyrrohdine. an aryl substituted olefinic tertiary amine compound is provided Other representatix e olefinic alcohols include 4-penten- l -ol, 5-hexen-2-ol, 5-hexen-3-ol, 3-methvl-3-buten- l -ol, 2-methvl-3-buten- l -ol. 4-methyl- -10- SUBSTΓTUTE SHEET (RULE 26) 4-penten-l-ol, 4-methyl-4-penten-2-ol. l-octen-4-ol, 5 -methyl- l-hepten-4-ol, 4- mefhvl-5-hexen-2-ol, 5-methyl-5-hexen-2-ol, 5-hexen-2-ol and 5-methyl-5-hexen-3- ol Tπfluormethvl-substituted olefinic alcohols, such as l . l , l-tπfluoro-4-penten-2-ol, can be prepared from l-ethoxy-2,2,2-tπfluoro-ethanol and allyltπmethvlsilane using the procedures of Kubota et al . Tetrahedron Letters, Vol 33(10), pp 1351-1354 ( 1992), or from tπfluoroacetic acid ethyl ester and allyltπbutylstannane using the procedures of Ishihara et al . Tetrahedron Letters. Vol 34(56), pp 5777-5780 (1993) Certain olefinic alcohols are optically active, and can be used as enantiomeπc mixtures or as pure enantiomers in order to provide the corresponding optically active forms of aryl substituted olefinic amine compounds When an olefinic allyhc alcohol, such as methallyl alcohol, is reacted with an aromatic halide, an aryl substituted olefinic aldehyde is produced, and the resulting aldehyde can be converted to an aryl substituted olefinic amine compound by reductive amination (e g , by treatment using an alkyl amine and sodium cyanoborohydπde) Preferred aromatic hahdes are 3- bromopyπdine-type compounds and 3-ιodopyπdιne-type compounds Typically, substituent groups of such 3-halopyπdιne-type compounds are such that those groups can survive contact with those chemicals (e g , tosylchloπde and methylamine) and the reaction conditions expeπenced duπng the preparation of the aryl substituted olefinic amine compound Alternatively, substituents such as -OH, -NH 2 and -SH can be protected as corresponding acyl compounds, or substituents such as -NH 2 can be protected as a phthahmide functionality The manner in which certain aryl substituted olefinic amine compounds possessing a branched side chain, such as (4E)-N-methyl-5-(5-ιsopropoxy-3-pyπdyl)- 4-penten-2-amιne, are provided can vary By using one synthetic approach, the latter compound can be synthesized in a convergent manner, in which the side chain, N- methyl-N-(tert-butoxycarbonyl)-4-penten-2-amιne is coupled with the 3-substιtuted 5- halo-substituted pyπdine, 5-bromo-3-ιsopropoxypyπdιne, under Heck reaction conditions, followed by removal of the tert-butoxycarbonyl protecting group Typically, the types of procedures set forth in W C Frank et al , J Org Chem 43 2947 ( 1978) and N J Malek et al , J Oig Chem 47 5395 ( 1982) involving a palladium-catalyzed coupling of an olefin and an aromatic halide are used The required N-methyl-N-(tert-butoxycarbonyl)-4-penten-2-amιne can be synthesized as follows (I) Commercially available 4-penten-2-ol (Aldπch Chemical Company. Lancaster Synthesis Inc ) can be treated with p-toluenesulfonyl chloπde in pyπdine to yield 4-penten-2-ol p-toluenesulfonate, previously descπbed by T Michel, et al , Liebigs Ann 11 181 1 ( 1996) ( n) The resulting tosylate can be heated with 20 molar equivalents of methylamine as a 40% aqueous solution to yield N-methvI-4-penten-2- amine (in) The resulting amine. such as previously mentioned b\ A \ lola et al , J Chem Soc , Chem Commun (21) 1429 ( 1984), can be allowed to react with 1.2 molar equivalents of di-tert-butvl dicarbonate in dry tetrahydrofuran to yield the side chain, N-methyl-N-(tert-butox\carbonyi)-4-penten-2-amιne The halo-substituted pyπdine, (e g , 5-bromo-3-ιsopropoxypyπdιne) can be synthesized bv two different routes In one preparation, 3.5-dιbromopyπdιne is heated at 140°C for 14 hours with 2 molar equivalents of potassium isopropoxide in dry isopropanol in the presence of copper powder (5%, w/w of the 3,5-dιbromopyπdιne) in a sealed glass tube to yield 5- bromo-3-ιsopropoxypyπdιne A second preparation of 5-bromo-3-isopropoxypyndme from 5-bromonιcotιnιc acid can be performed as follows (I) 5-Bromonιcotιnιc acid is converted to 5-bromonιcotιnamιde by treatment with thionyl chloride, followed by reaction of the intermediate acid chloride with aqueous ammonia (n) The resulting 5- bromonicotinamide, previously described by C V Greco et al , J Heteocvchc Chem 7(4) 761 (1970), is subjected to Hofmann degradation by treatment with sodium hydroxide and a 70% solution of calcium hypochloπte (in) The resulting 3-ammo-5- bromopyπdine, previously described by C V Greco et al , J Heteoc\ die Chem 7(4) 761 (1970), can be converted to 5-bromo-3-ιsopropoxypyπdιne bv diazotization with isoamyl mtπte under acidic conditions, followed by treatment of the intermediate diazomum salt with isopropanol to yield 5-bromo-3-ιsopropoxypyπdιne The palladium-catalyzed coupling of 5-bromo-3-ιsopropoxypyπdιne and N-methyl-N- (tert-butoxycarbonyl)-4-penten-2-amιne is earned out in acetonitπle-tπethylamme (2 1 , v,v) using a catalyst consisting of 1 mole % palladιum(II) acetate and 4 mole % tπ-o-tolylphosphine The reaction can be earned out by heating the components at 80°C for 20 hours to yield (4E)-N-methyl-N-(tert-butoxycarbonvl )-5-(5-ιsopropoxy- 3-pyπdyl)-4-penten-2-amιne Remov al of the tert-butoxycarbony l protecting group can be accomplished by treatment w ith 30 molar equivalents of tπfluoroacetic acid in anisole at 0°C to afford (4E)-\-methv l-5-(5-ιsopropoxγ-3-pynd\ l)-4-penten-2-amιne The manner in which certain arvl substituted olefinic amine compounds possessing a branched side chain are prov ided can vary Lsing one sv nthetic -12- SUBSTΓΠΠΈ SHEET (RULE 26) approach, a compound such as l-5-( 5-methoxy-3-pyπdyl)-4-penten-2- amine can be synthesized by coupling a halo-substituted pyπdine, 5-bromo-3- methoxypyπdine with an olefin containing a secondary alcohol functionality, 4- penten-2-ol. under Heck reaction conditions, and the resulting pyridyl alcohol intermediate can be converted to its p-toluenesulfonate ester, followed by treatment with mefhvlamine Typically, the types of procedures set forth in W C Frank et al , J Org Chem 43 2947 (1978) and N J Malek et al . J Org Chem 47 5395 ( 1982) involving a palladium-catalyzed coupling of an olefin and an aromatic halide are used The required halo-substituted pyndine. 5-bromo-3-methoxypyπdιne is synthesized using methodology similar to that descπbed by H J den Hertog et al , Reel Trav Chun Pavs-Bas 14 1 171 (1955) namely by heating 3, 5-dιbromopyπdιne with 2 5 molar equivalents of sodium methoxide m drv methanol in the presence of copper powder (5%, w/w of the 3,5-dιbromopyπdme) in a sealed glass tube at 150°C for 14 hours to produce 5-bromo-3-mefhoxypyπdιne The resulting 5-bromo-3- methoxypyπdine, previously descπbed by D L Comins, et al , J Org Chem 55 69 ( 1990), can be coupled with 4-penten-2-ol in acetonitπle-tnefhylamme ( 1 1 1. v/v) using a catalyst consisting of 1 mole % palladιum(II) acetate and 4 mole % tπ-o- tolylphosphme The reaction is carried out by heating the components in a sealed glass tube at 140°C for 14 hours to yield (4E)-N-methyl-5-(5-methoxy-3-pyπdyl)-4- penten-2-ol The resulting alcohol is treated with 2 molar equivalents of p- toluenesulfonvl chloπde in dry pyndine at 0°C to produce (4E)-N-mefhyl-5-(5- methoxy-3-pvπdyl)-4-penten-2-ol p-toluensulfonate The tosylate intermediate is treated with 120-molar equivalents of methvlamine as a 40% aqueous solution, containing a small amount of ethanol as a co-solvent to produce (4E)-N-methyl-5-(5- methoxy-3-pyndyl)-4-penten-2-amme The manner in which optically active forms of certain aryl substituted olefinic amine compounds, such as (2S)-(4E)-N-methvl-5-(3-pyπdyl)-4-penten-2-amιne. are provided can vary In one synthetic approach, the latter type of compound is synthesized bv coupling a halo-substituted pyndine. 3-bromopyndιne, with an olefin possessing a chiral. secondary alcohol functionalit (2R)-4-penten-2-ol, under Heck reaction conditions The resulting chiral pyπdvl alcohol intermediate, (2R)-(4E)-5-(3- pyndyl)-4-penten-2-ol is converted to its corresponding p-toluenesulfonate ester. which is subsequentlv treated with methvlamine. resulting in tosylate displacement -13- SUBSTΓΓUTE SHEET (RULE 26) with inversion of configuration Typically, the types of procedures set forth in W C Frank et al . J Org Chem 43 2947 ( 1978) and N J Malek et al , J Org Chem 47 5395 (1982) involving a palladium-catalyzed coupling of an aromatic halide and an olefin are used The chiral side chain, (2R)-4-penten-2-ol can be prepared by -> treatment of the chiral epoxide, (R)-(+)-propylene oxide (commercially available from Fluka Chemical Companv) with vinylmagnesium bromide in tetrahydrofuran at low temperatures (-25 to -10°C) using the general synthetic methodology of A Kahvretenos, j K. Stille, and L S Hegedus, J Org Chem 56 2883 (1991), to afford (2R)-4-penten-2-ol The resulting chiral alcohol is subjected to a Heck reaction with 10 3-bromopyndιne in acetonitπle-tπethylamine (1 1 , v/v) using a catalyst consisting of 1 mole % palladιum(II) acetate and 4 mole % tn-o-tolylphosphine The reaction is done by heating the components at 140°C for 14 hours in a sealed glass tube, to produce the Heck reaction product, (2R)-(4E)-5-(3-pyndyl)-4-penten-2-ol The resulting chiral pyndyl alcohol is treated with 3 molar equivalents of p- 15 toluenesulfonyl chlonde in dry pyndine at 0°C, to afford the tosylate intermediate The p-toluenesulfonate ester is heated with 82 molar equivalents of methylamine as a 40% aqueous solution, containing a small amount of ethanol as a co-solvent, to produce (2S)-(4E)-N-methyl-5-(3-pyπdyl)-4-penten-2-amιne In a similar manner, the corresponding aryl substituted olefinic amine enantiomer, such as (2R)-(4E)-N- 0 methyl-5-(3-pyndyl)-4-penten-2-amιne, can be synthesized by the Heck coupling of 3-bromopyndme and (2S)-4-penten-2-ol The resulting intermediate, (2S)-(4E)-5-(3- pyπdyl)-4-penten-2-ol, is converted to its p-toluenesulfonate, which is subjected to methylamine displacement The chiral alcohol, (2S)-4-penten-2-ol. is prepared from (S)-(-)-propylene oxide (commercially available from Aldπch Chemical Company) 5 using a procedure analogous to that descnbed for the preparation of (2R)-4-penten-2- ol from (R)-(+)-propylene oxide as reported by A Kahvretenos, j K Stille. and L S Hegedus. J Org Chem 56 2883 ( 1991 ) The present invention relates to a method for providing pre ention of a condition or disorder to a subject susceptible to such a condition or disorder, and for ^0 providing treatment to a subject suffeπng therefrom For example, the method compπses admimsteπng to a patient an amount of a compound effectiv e for providing some degree of prevention of the progression of a CNS disorder (I e . provide protective effects), amelioration of the symptoms of a CNS disorder, and amelioration -14- SUBSTΓΓUTE SHEET (RULE 26) of the recurrence of a CNS disorder. The method involves administenng an effective amount of a compound selected from the general formulae which are set forth hereinbefore The present invention relates to a pharmaceutical composition incorporating a compound selected from the general formulae which are set forth hereinbefore Optically active compounds can be employed as racemic mixtures or as enantiomers The compounds can be employed in a free base form or in a salt form (e.g., as pharmaceutically acceptable salts) Examples of suitable pharmaceutically acceptable salts include inorganic acid addition salts such as hydrochloπde, hydrobromide, sulfate, phosphate, and nitrate, organic acid addition salts such as acetate, galactarate, propionate, succmate. lactate, glycolate, malate, tartrate, citrate, maleate, fumarate, methanesulfonate, p-toluenesulfonate, and ascorbate; salts with acidic amino acid such as aspartate and glutamate; alkali metal salts such as sodium salt and potassium salt; alkaline earth metal salts such as magnesium salt and calcium salt, ammonium salt; organic basic salts such as tnmethylamine salt, tnethylamine salt, pyπdine salt, picohne salt, dicyclohexylamme salt, and N,N'- dibenzylefhylenediamine salt; and salts with basic amino acid such as lysine salt and arginme salt. The salts may be in some cases hydrates or ethanol solvates Representative salts are provided as described in U.S Patent Nos. 5,597,919 to Dull et al., 5,616,716 to Dull et al. and 5,663,356 to Ruecroft et al Compounds of the present invention are useful for treating those types of conditions and disorders for which other types of nicotinic compounds have been proposed as therapeutics See, for example. Williams et al DN&P 7(4).205-227 (1994), Arneπc et al., CNS Drug Rev 1(1) 1 -26 ( 1995), Arnenc et al., Exp Opin Invest Drugs 5(1) 79-100 (1996), Bencherif et al., JPET 219 1413 ( 1996), Lippiello et al., JPET219.1422 ( 1996), Damaj et al . Neuroscience ( 1997), Holladay et al.. J Med. Chem 40(28) 4169-4194 (1997), Bannon et al , Science 279 77-80 ( 1998), PCT WO 94/08992. PCT WO 96/31475, and U S Patent Nos 5,583,140 to Bencheπf et al, 5,597,919 to Dull et al., and 5,604,231 to Smith et al Compounds of the present invention can be used as analgesics, to treat ulcerative colitis, and to treat convulsions such as those that are symptomatic of epilepsy CNS disorders which can be treated in accordance with the present invention include presemle dementia (early onset Alzheimer's disease), senile dementia (dementia of the Alzheimer's type), Parkmsonism including Parkinson ' s disease. Huntington s chorea, tardive dyskinesia. hyperkinesia, mania, attention deficit disorder, anxiety, dyslexia, schizophrenia and Tourette's syndrome The pharmaceutical composition also can include vaπous other components as additives or adjuncts Exemplary pharmaceutically acceptable components or adjuncts which are employed in relevant circumstances include antioxidants, free radical scavenging agents, peptides, growth factors, antibiotics, bacteπostatic agents, immunosuppressives, anticoagulants, buffering agents, anti-inflammatory agents, antipyretics, time release binders, anaesthetics, steroids and corticosteroids. Such components can provide additional therapeutic benefit, act to affect the therapeutic action of the pharmaceutical composition, or act towards preventing any potential side effects which may be posed as a result of administration of the pharmaceutical composition In certain circumstances, a compound of the present invention can be employed as part of a pharmaceutical composition with other compounds intended to prevent or treat a particular disorder. The manner in which the compounds are administered can vary The compounds can be administered by inhalation (e.g., in the form of an aerosol either nasally or using delivery articles of the type set forth in U.S. Patent No. 4,922,901 to Brooks et al.), topically (e.g., in lotion form); orally (e.g., in liquid form within a solvent such as an aqueous or non-aqueous liquid, or within a solid earner), intravenously (e.g , within a dextrose or saline solution), as an infusion or injection (e.g., as a suspension or as an emulsion in a pharmaceutically acceptable liquid or mixture of liquids), intrathecally, intracerebro ventπcularly, or transdermally (e.g , using a transdermal patch) Although it is possible to administer the compounds in the form of a bulk active chemical, it is preferred to present each compound in the form of a pharmaceutical composition or formulation for efficient and effective administration Exemplary methods for administering such compounds will be apparent to the skilled artisan For example, the compounds can be administered in the form of a tablet, a hard gelatin capsule or as a time release capsule As another example, the compounds can be delivered transdermally using the types of patch technologies available from Novartis and Alza Corporation The administration of the pharmaceutical compositions of the present invention can be intermittent, or at a gradual, continuous, constant or controlled rate to a warm-blooded animal, (e g., a mammal such as a mouse, rat. cat. rabbit, dog, pig, cow. or monkey); but -16- SUBSTΓ LΠΈ SHEET (RULE 26) advantageously is preferably administered to a human being In addition the time of dav and the number of times per dav that the pharmaceutical formulation is administered can var Administration preferably is such that the activ e ingredients of the pharmaceutical formulation interact with receptor sites within the body of the subject that affect the functioning of the CNS More specifically, in treating a CNS disorder administration preferably is such so as to optimize the effect upon those relevant receptor subtypes which have an effect upon the functioning of the CNS, while minimizing the effects upon muscle-type receptor subtypes Other suitable methods for administenng the compounds of the present invention are descπbed in U S Patent No 5,604,231 to Smith et al , the disclosure of which is incoφorated herein by reference in its entirety The appropπate dose of the compound is that amount effective to prevent occurrence of the symptoms of the disorder or to treat some symptoms of the disorder from which the patient suffers By "effective amount", "therapeutic amount" or "effective dose" is meant that amount sufficient to elicit the desired pharmacological or therapeutic effects, thus resulting in effective prevention or treatment of the disorder Thus, when treating a CNS disorder, an effective amount of compound is an amount sufficient to pass across the blood-brain barπer of the subject, to bind to relevant receptor sites in the brain of the subject, and to activate relevant nicotinic receptor subtypes (e g , provide neurotransmitter secretion, thus resulting in effective prevention or treatment of the disorder) Prevention of the disorder is manifested by delaying the onset of the symptoms of the disorder Treatment of the disorder is manifested by a decrease in the svmptoms associated with the disorder or an amelioration of the recurrence of the svmptoms of the disordei Relative to (E)- metanicotme, compounds of the present invention are less extensivelv metabolized (1 e , fewer metabolites are formed, and the rate of elimination from blood is slower) in mammalian systems As such, as compared to (E)-metamcotιne, compounds of the present invention are capable of providing higher absolute plasma concentrations, and are capable of being maintained within a mammalian system for longer periods of time Thus, compounds of the present invention are capable of providing comparable therapeutic effects of (E)-metanιcotme at low doses The effective dose can v arv, depending upon factors such as the condition of the patient, the seveπtv of the s mptoms of the disorder, and the manner in hich the pharmaceutical composition is administered For human patients, the effective dose of typical compounds generally requires admimsteπng the compound in an amount sufficient to activate relevant receptors to effect neurotransmitter (e.g , dopamine) release but the amount should be insufficient to induce effects on skeletal muscles and ganglia to anv significant degree The effectiv e dose of compounds will of course differ from patient to patient but in general includes amounts starting where CNS effects or other desired therapeutic effects occur, but below the amount where muscular effects are observed Typically, the effective dose of compounds generally requires admimstenng the compound in an amount of less than 5 mg/kg of patient weight Often, the compounds of the present invention are administered in an amount from 1 mg to less than 100 ug/kg of patient weight, frequentlv between about 10 ug to less than 100 ug/kg of patient weight, and preferably between about 10 ug to about 50 ug kg of patient weight For compounds of the present invention that do not induce effects on muscle type nicotinic receptors at low concentrations, the effective dose is less than 5 mg/kg of patient weight; and often such compounds are administered in an amount from 50 ug to less than 5 mg/kg of patient weight The foregoing effective doses typically represent that amount administered as a single dose, or as one or more doses administered over a 24 hour peπod For human patients, the effective dose of typical compounds generally requires administering the compound in an amount of at least about 1 , often at least about 10, and frequently at least about 25 ug/ 24 hr / patient For human patients, the effective dose of typical compounds requires admimstenng the compound which generally does not exceed about 500, often does not exceed about 400, and frequently does not exceed about 300 ug/ 24 hr / patient In addition, administration of the effective dose is such that the concentration of the compound within the plasma of the patient normally does not exceed 500 ng/ml, and frequently does not exceed 100 ng/ml The compounds useful according to the method of the present invention have the ability to pass across the blood-brain barπer of the patient As such, such compounds hav e the ability to enter the central nervous system of the patient The log P values of typical compounds, which are useful in carrying out the present invention are generally greater than about 0, often are greater than about 0 5, and frequently are greater than about 1. The log P values of such typical compounds generally are less than about 3.5, often are less than about 3, and sometimes are less than about 2.5. Log P values provide a measure of the ability of a compound to pass across a diffusion barπer. such as a biological membrane. See, Hansch. et al., J. Med. Chem. 1 1 : 1 ( 1968). The compounds useful according to the method of the present invention have the ability to bind to, and in most circumstances, cause activation of, nicotinic chohnergic receptors of the brain of the patient (e.g., such as those receptors that modulate dopamine release). As such, such compounds have the ability to express nicotinic pharmacology, and in particular, to act as nicotinic agonists. The receptor binding constants of typical compounds useful in carrying out the present invention generally exceed about 0.1 nM. often exceed about 1 nM, and frequently exceed about 10 nM. The receptor binding constants of such typical compounds generally are less than about 1 uM, often are less than about 100 nM, and frequently are less than about 50 nM. Receptor binding constants provide a measure of the ability of the compound to bind to half of the relevant receptor sites of certain brain cells of the patient. See, Cheng, et al, Biochem. Pharmacol. 22:3099 (1973). The compounds useful according to the method of the present invention have the ability to demonstrate a nicotinic function by effectively eliciting ion flux through, and or neurotransmitter secretion from, nerve ending preparations (e.g., thalamic or stπatal synaptosomes). As such, such compounds have the ability to cause relevant neurons to become activated, and to release or secrete acetylcholme, dopamine, or other neuro transmitters. Generally, typical compounds useful in carrying out the present invention effectively provide for relevant receptor activation in amounts of at least about 30 percent, often at least about 50 percent, and frequently at least about 75 percent, of that maximally provided by (S)-(-)-nicotιne. Generally, typical compounds useful in carrying out the present invention are more potent than ( S)-(-)-nιcotιne in eliciting relevant receptor activation. Generally, typical compounds useful in carrying out the present invention effectively provide for the secretion of dopamine in amounts of at least about 50 percent, often at least about 75 percent, and frequently at least about 100 percent, of that maximally provided by (S)-(-)-mcotme Certain compounds of the present invention can provide secretion of dopamine in an amount which can exceed that maximally provided by (S)-(-)-nιcotme. Generally, typical -19- SUBSTΠTΠΈ SHEET (RULE 26) compounds useful in carrying out the present invention are less potent than (S)-(-)- mcotme in eliciting neurotransmitter secretion, such as dopamine secretion The compounds of the present invention, w hen employed in effective amounts in accordance with the method of the present invention, lack the ability to elicit activation of nicotinic receptors of human muscle to any significant degree In that regard, the compounds of the present invention demonstrate poor ability to cause isotopic rubidium ion flux through nicotinic receptors in cell preparations expressing muscle-type nicotinic acetylchohne receptors Thus, such compounds exhibit receptor activation constants or EC50 values (1 e , which provide a measure of the concentration of compound needed to activate half of the relevant receptor sites of the skeletal muscle of a patient) which are extremely high (I e , greater than about 100 uM) Generally, typical preferred compounds useful in carrying the present invention activate isotopic rubidium ion flux by less than 10 percent, often by less than 5 percent, of that maximally provided by S(-) nicotine The compounds of the present invention, when employed in effective amounts m accordance with the method of the present invention, are selective to certain relevant nicotinic receptors, but do not cause significant activation of receptors associated with undesirable side effects. By this is meant that a particular dose of compound resulting in prevention and or treatment of a CNS disorder, is essentially ineffective in eliciting activation of certain ganghonic-type nicotinic receptors This selectivity of the compounds of the present invention against those receptors responsible for cardiovascular side effects is demonstrated by a lack of the ability of those compounds to activate nicotinic function of adrenal chromaffin tissue As such, such compounds have poor ability to cause isotopic rubidium ion flux through nicotinic receptors in cell preparations derived from the adrenal gland Generally, typical preferred compounds useful in carrying out the present invention activate isotopic rubidium ion flux by less than 10 percent, often by less than 5 percent, of that maximally provided by S(-) nicotine. Compounds of the present invention, when employed in effective amounts in accordance with the method of the present invention, are effective towards providing some degree of prevention of the progression of CNS disorders, amelioration of the symptoms of CNS disorders, and amelioration to some degree of the recurrence of CNS disorders However, such effectiv e amounts of those compounds are not sufficient to elicit any appreciable side effects, as is demonstrated by decreased effects on preparations believed to reflect effects on the cardiovascular system, or effects to skeletal muscle. As such, administration of compounds of the present invention provides a therapeutic window in which treatment of certain CNS disorders is provided, and side effects are avoided That is, an effective dose of a compound of the present invention is sufficient to provide the desired effects upon the CNS. but is insufficient (i.e., is not at a high enough level) to provide undesirable side effects. Preferably, effective administration of a compound of the present invention resulting in treatment of CNS disorders occurs upon administration of less 1/3, frequently less than 1/5, and often less than 1 /10, that amount sufficient to cause any side effects to a significant degree. The following examples are provided to illustrate the present invention, and should not be construed as limiting thereof. In these examples, all parts and percentages are by weight, unless otherwise noted. Reaction yields are reported in mole percentages. Several commercially available starting matenals are used throughout the following examples. 3-Bromopyridine, 3,5-dibromopyπdιne, 5- bromonicotinic acid, 5-bromopynmidmc, and 4-penten-2-ol were obtained from Aldπch Chemical Company or Lancaster Synthesis Inc. 2-Amιno-5-bromo-3- methylpyndine was purchased from Maybπdge Chemical Company Ltd. (R)-(+)- propylene oxide was obtained from Fluka Chemical Company, and (S)-(-)-propylene oxide was obtained from Aldrich Chemical Company. Column chromatography was done using either Merck silica gel 60 (70-230 mesh) or aluminum oxide (activated, neutral, Brockmann I, standard grade, ~150 mesh). Pressure reactions were done in a heavy wall glass pressure tube ( 185 mL capacity), with Ace-Thread, and plunger valve available from Ace Glass Inc. Reaction mixtures were typically heated using a high-temperature silicon oil bath, and temperatures refer to those of the oil bath. The following abbreviations are used in the following examples: CHCL for chloroform, CH 2 C1 2 for dichloromethane, CH,OH foi .nethanol, DMF for N,N- dimethylformamide, and EtOAc for ethyl acetate, THF for tetrahydrofuran, and Et 3 N for tnethylamine. EXAMPLE 1 -21 - SUBSTΓTUTE SHEET (RULE 26) Determination of Log P Value Log P values, which have been used to assess the relative abilities of compounds to pass across the blood-brain barner (Hansch, et al , J Med Chem ii: l ( 1968)), were calculated using the Cerius " software package Version 3 5 by Molecular Simulations, Inc. EXAMPLE 2 Determination of Binding to Relevant Receptor Sites Binding of the compounds to relevant receptor sites was determined in accordance with the techniques described in U.S. Patent No 5,597,919 to Dull et al. Inhibition constants (Ki values), reported in nM, were calculated from the ICso values using the method of Cheng et al , Biochem, Pharmacol 22.3099 ( 1973) EXAMPLE 3 Determination of Dopamine Release Dopamine release was measured using the techniques described in U.S. Patent No. 5,597,919 to Dull et al Release is expressed as a percentage of release obtained with a concentration of (S)-(-)-nιcotιne resulting in maximal effects Reported EC 5 o values are expressed in nM, and E max values represent the amount released relative to (S)-(-)-nιcotιne on a percentage basis EXAMPLE 4 Determination of Rubidium Ion Release Rubidium release was measured using the techniques described in Bencheπf et al, JPET, 279: 1413-1421 (1996) Reported EC- 0 values are expressed in nM, and E m a- values represent the amount of rubidium ion released relative to 300 uM tetrarnefhylammonium ion, on a percentage basis EXAMPLE 5 Determination of Interaction with Muscle Receptors The determination of the interaction of the compounds w ith muscle receptors was carried out in accordance with the techniques descπbed in U S Patent No 5,597,919 to Dull et al The maximal activation for individual compounds (E ma\ ) was -22- SUBSTmifi SHEET (RULE 26) determined as a percentage of the maximal activ ation induced by (S)-(-)-nιcotme Reported E m a x values represent the amount released relative to (S)-(-)-nιcotιne on a percentage basis. EXAMPLE 6 Determination of Interaction with Ganglion Receptors The determination of the interaction of the compounds with ganghonic receptors was earned out in accordance with the techniques descnbed in U.S. Patent No. 5,597,919 to Dull et al. The maximal activation for individual compounds (E max ) was determined as a percentage of the maximal activation induced by (S)-(-)-nιcotιne. Reported E max values represent the amount released relative to (S)-(-)-nιcotιne on a percentage basis EXAMPLE 7 Sample No. 1 is (4E)-N-methyl-5-(3-pyπdyl)-4-penten-2-amιne hemigalactarate, which was prepared in accordance with the following techniques. (4E)-5-(3-Pyndyl)-4-penten-2-ol A mixture of 3-bromopyndιne (7.50 g, 47 46 mmol), 4-penten-2-ol (4.90 g, 56.96 mmol), palladιum(II) acetate (106 mg, 0 47 mmol), tπ-o-tolylphosphine (575 mg, 1.89 mmol), tπethylamine (28.4 mL, 204.1 1 mmol) and acetomtπle (25 mL) were heated in a sealed glass tube at 140°C for 14 h The reaction mixture was cooled to ambient temperature, diluted with water, and extracted with chloroform (3 x 200 mL) The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation to give a pale-yellow oil (7.50 g, 81.0 %). (4E)-5-(3-Pyπdyl)-4-penten-2-ol p-Toluenesulfonate To a stirred solution of (4E)-5-(3-pyπdyl)-4-penten-2-ol (5.00 g, 30 67 mmol) in dry pyridine (30 mL) at 0°C was added p-toluenesulfonyl chloπde (8 77 g, 46.01 mmol) The reaction mixture was stirred for 24 h at ambient temperature. The pyπdine was removed by rotary evaporation Toluene (50 mL ) w as added to the residue and subsequently removed by rotarv evaporation The crude product was stirred with a saturated solution of sodium bicarbonate ( 100 mL) and extracted with chloroform (3 x 100 mL) The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation The crude product was punfied by column chromatography over aluminum oxide, eluting with ethyl acetate-hexane (3 7, v/v). Selected fractions were combined and concentrated by rotary evaporation to give a v iscous, brown oil (5.83 g, 60 1 %) (4E)-N-Methyl-5-(3-pyndyl)-4-penten-2-amιne A mixture of (4E)-5-(3-pyndyl)-4-penten-2-ol p-toluenesulfonate (5 60 g, 17 66 mmol), methylamine (100 mL. 40% solution in water), and ethyl alcohol ( 10 mL) was stirred at ambient temperature for 18 h The resulting solution was extracted with chloroform (3 x 100 mL) The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation. The crude product was punfied by column chromatography over aluminum oxide, eluting with ethyl acetate- methanol (7.3, v/v). Selected fractions were combined and concentrated by rotary evaporation, producing an oil Further punfication by vacuum distillation furnished 1 60 g (51.6%) of a colorless oil, bp 1 10-120°C at O 1 mm Hg (4E)-N-Methyl-5-(3-pyndyl)-4-penten-2-amιne Hemιgalactarate (4E)-N-Methyl-5-(3-pyπdyl)-4-penten-2-amme (1 60 g, 9 10 mmol) was dissolved in ethyl alcohol (20 mL), assisted by warming to 60°C The warm solution was treated with galactaπc acid (955 mg, 4 54 mmol) in one portion, followed by the dropwise addition of water (0.5 mL) The solution was filtered while hot to remove some insoluble matenal. The filtrate as allowed to cool to ambient temperature The resulting crystals were filtered, ashed with anhydrous diethyl ether, and dπed under vacuum at 40°C to yield 1 20 g (47 0%) of a white, crystalline powder, mp 148- 150°C Sample No 1 exhibits a log P of 1 924, and such a favorable log P value indicates that the compound has the capability of passing the blood-bram barrier The -24- SUBSTΓΓUTE SHEET (RULE 26) sample exhibits a Ki of 83 nM. The low binding constant indicates that the compound exhibits good high affinity binding to certain CNS nicotinic receptors Sample No 1 exhibits an EC 50 value of 6600 nM and an E m a X value of 1 13% for dopamine release, indicating that the compound induces neurotransmitter release thereby exhibiting known nicotinic pharmacology The sample exhibits an EC^ value of 3100 nM and an E max value of 35% in the rubidium ion flux assay, indicating that the compound effectively induces activation of CNS nicotinic receptors. Sample No 1 exhibits an E max of 13% (at a concentration of 100 uM) at muscle-type receptors, indicating that the compound does not induce activation of muscle-type receptors The sample exhibits an E m aχ of 62% (at a concentration of 100 uM) at ganglionic-type receptors. At certain levels the compound shows CNS effects to a significant degree but show neither undesirable muscle nor ganglion effects to any significant degree The compound begins to cause muscle and ganglion effects only when employed in amounts of several times those required to activate rubidium ion flux and dopamine release, thus indicating a lack of certain undesirable side effects in subjects receiving administration of that compound. EXAMPLE 8 Sample No. 2 is (2R)-(4E)-N-methyl-5-(3-pyndyl)-4-penten-2-amιne hemigalactarate, which was prepared in accordance ith the following techniques (2S)-4-Penten-2-ol (2S)-4-Penten-2-ol was prepared from (S)-(-)-propylene oxide using a procedure similar to that descπbed for the preparation of (2R)-4-penten-2-ol from (R)-(+)- propylene oxide as detailed in A Kahvretenos. J K Stille, and L S. Hegedus. J Org Chem 56 2883 (1991) Thus, a 1.0M solution of vmvlmagnesium bromide in THF (129 mL, 129 0 mmol) was slowly added to a suspension of copper(I) iodide (2 46 g, 12.92 mmol) in dry THF (40 mL, distilled from sodium and benzophenone) at -25°C After stirring 5 mm, a solution of (S)-(-)-propylene oxide (5 00 g, 86 1 mmol) in dry THF (5 mL) was added The mixture w as allowed to arm to -10°C and placed in a freezer at 0°C for 12 h The mixture was stirred for an additional 1 h at 0°C and poured into a mixture of saturated ammonium chloride solution (100 mL) and ice -25- SUBSTΓΓUTE SHEET (RULE 26) ( 100 g). The mixture was stirred for 4 h and extracted with ether (3 x 100 mL). The combined ether extracts were dried (K 2 COt), filtered, and concentrated under reduced pressure by rotary evaporation at 0°C The resulting brown oil was vacuum distilled to yield 5.86 g (79.1%) of a colorless distillate, bp 37-39°C at 9 mm Hg (2S)-(4E)-5-(3-Pyπdyl)-4-penten-2-ol A mixture of 3-bromopyndιne ( 1 1.22 g, 70.58 mmol), (2S)-4-penten-2-ol (5.00 g, 58.05 mmol), palladιum(II) acetate (527 mg, 2.35 mmol), tπ-o-tolylphosphine (1.79 g, 5.88 mmol), tnethylamine (30 mL, 216 mmol) and acetonitnle (30mL) were heated in a sealed glass tube at 130-140°C for 8 h The reaction mixture was cooled to ambient temperature. The solvent was removed under reduced pressure on a rotary evaporator. Water (20 mL) was added and the mixture was extracted with chloroform (4 x 50 mL). The combined chloroform extracts were dned (K 2 C0 1 ), filtered, and concentrated by rotary evaporation, producing a pale-yellow oil (6.00 g). The crude product was purified by column chromatography over silica gel, eluting with chloroform-acetone (95:5, v/v). Selected fractions were combined and concentrated by rotary evaporation, affording 3 95 g (41 7% > ) of a pale-yellow oil (2S)-(4E)-5-(3-Pyndyl)-4-penten-2-ol p-Toluenesufonate Under a nitrogen atmosphere, p-toluenesufonyl chloπde (7.01 g, 36 77 mmol) was added to a stirπng solution of (2S)-(4E)-5-(3-pyπdyl)-4-penten-2-ol (3 00 g, 18.38 mmol) in dry tnethylamine (20 mL) at 0°C. After stirnng and warming to ambient temperature over 18 h, the mixture was stirred with cold, saturated NaHC0 3 solution (50 mL) for 1 hour and extracted with chloroform (3 x 50 mL). The combined chloroform extracts were dried (K 2 CO , filtered, and concentrated by rotary evaporation to afford a thick, dark-brown mass (~7 g) The crude product was punfied by column chromatography on silica gel, eluting with chloroform-acetone (98.2, v/v) to afford 4.00 g (68.6%) of a light-brown syrup. (2R)-(4E)-N-Methyl-5-(3-pyπdyl)-4-penten-2-amιne A mixture of (2S)-(4E)-5-(3-pyndyl)-4-penten-2-ol p-toluenesulfonate (3 80 g, 1 1 97 mmol) and methylamine (20 mL, 2.0M solution in THF) was heated at 100- 1 10°C for 8 h in a sealed glass tube The mixture was cooled to ambient temperature and concentrated under reduced pressure on a rotary evaporator The resulting brown syrup was diluted with saturated NaHCOi solution (25 mL) and extracted with chloroform (4 x 25 mL) The combined chloroform extracts were dned (K 2 COι), filtered, and concentrated by rotary evaporation to afford a thick, brown syrup (2.00 g). The crude product was punfied by column chromatography on silica gel, eluting with chloroform-methanol (95:5, v/v) Selected fractions were combined, concentrated by rotary evaporation affording a 800 mg (37 9%) of a pale-yellow oil (2R)-(4E)-N-Methyl-5-(3-pyπdyl)-4-penten-2-amιne Hemigalactarate Galactaπc acid (328.0 mg, 1.56 mmol) and (2R)-(4E)-N-methyl-5-(3-pyπdyl)-4- penten-2-amme (600 0 mg, 3.40 mmol) were dissolved in 2-propanol (5 mL) and water (0.2 mL), assisted by heating and somcation. The hot solution was filtered to remove some insoluble matenal. The solvent was removed on a rotary evaporator, and the residue was dned under high vacuum, producing a cream-colored syrup The syrup was dissolved in dry 2-propanol (5 mL) and cooled at 4°C The resulting precipitate was filtered and dned under high vacuum to yield 700 mg (79 7%) of an off-white, crystalline powder, mp 131 -134°C Sample No 2 exhibits a log P of 1.924, and such a favorable log P value indicates that the compound has the capability of passing the blood-brain barrier. The sample exhibits a Ki of 520 nM, indicating that the compound exhibits binding to certain CNS nicotinic receptors Sample No 2 exhibits an ECso value of 27400 nM and an E ma value of 76% for dopamine release, indicating that the compound induces neurotransmitter release thereby exhibiting known nicotinic pharmacology The sample exhibits an EC-,o value of 4390 nM and an E max value of 32% in the rubidium ion flux assay, indicating that the compound induces activation of CNS nicotinic receptors Sample No. 2 exhibits an E ma of 0% (at a concentration of 100 uM) at muscle-type receptors, indicating that the compound does not induce activation of muscle-type receptors Sample No 1 exhibits an E m a x of 36% (at a concentration of -27- SUBSTΪTUTE SHEET (RULE 26) 100 uM) at ganghonic-tvpe receptors The compound has the capability to activate human CNS receptors without activating muscle-type and ganglionic-type nicotinic acetylchohne receptors to any significant degree Thus, there is provided a therapeutic window for utilization in the treatment of CNS disorders That is, at certain levels the compound shows CNS effects to a significant degree but does not show undesirable muscle and ganglion effects to any significant degree EXAMPLE 9 Sample No 3 (2S)-(4E)-N-methyl-5-(3-pyndyl)-4-penten-2-amιne hemigalactarate, which was prepared in accordance with the following techniques (2R)-4-Penten-2-ol (2R)-4-Penten-2-ol was prepared in 82 5% yield from (R)-(+)-propylene oxide according to procedures set forth in A Kahvretenos, J K Stille, and L S Hegedus, J Org Chem 56 2883 (1991) (2R)-(4E)-5-(3-Pyndyl)-4-penten-2-ol A mixture of 3-bromopyndιne (9 17 g, 58 04 mmol), (2R)-4-penten-2-ol (6 00 g, 69 65 mmol), palladιum(II) acetate (130 mg, 0 58 mmol), tπ-o-tolylphosphine (710 mg, 2 32 mmol), tnethylamine (34 7 mL, 249 5 mmol), and acetonitnle (35 mL) were heated in a sealed glass tube at 140°C for 14 h The reaction mixture was cooled to ambient temperature, diluted with water, and extracted with chloroform (3 x 200 mL) The combined chloroform extracts were dned over sodium sulfate, filtered, and concentrated by rotary evaporation to give 6 17 g (65 2%) of a pale-yellow oil (2R)-(4E)-5-(3-Pyπdyl)-4-penten-2-ol p-Toluenesulfonate To a stirring solution of (2R)-(4E)-5-(3-pyndyl)-4-penten-2-ol (6 00 g, 36 81 mmol) in dry pyndine (30 mL) at 0°C was added p-toluenesulfonyl chloπde (21 05 g, 1 10 43 mmol) The reaction mixtuie was stirred for 24 h at ambient temperature The pyndine was removed bv rotarv evaporation Toluene ( 50 mL) was added to the -28- SUBSTΠTΠΈ SHEET (RULE 26) residue and subsequently remov ed by rotary evaporation The crude product was stirred with a saturated solution of sodium bicarbonate ( 100 mL) and extracted with chloroform (3 x 100 mL) The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation to give 1 1 67 g (84 0%) of a dark-brown, viscous oil (2S)-(4E)-N-Methyl-5-(3-pyndyl)-4-penten-2-amιne A mixture of (2R)-(4E)-5-(3-pyπdyl)-4-penten-2-ol p-toluenesulfonate (9 00 g, 28.35 mmol), methylamine (200 mL, 40% solution in water), and ethyl alcohol (10 mL) was stirred at ambient temperature for 18 h The resulting solution was extracted with chloroform (3 x 100 mL) The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation The crude product was punfied by column chromatography over aluminum oxide, eluting with ethyl acetate- methanol (7.3, v/v). Selected fractions were combined and concentiated by rotary evaporation, producing an oil Further puπfication by vacuum distillation furnished 1.20 g (24.0 %) of a colorless oil. bp 90-100°C at 0 5 mm Hg (2S)-(4E)-N-Methyl-5-(3-pyπdyl)-4-penten-2-amιne Hemιgalactarate (2S)-(4E)-N-Methyl-5-(3-pyπdvl)-4-penten-2-amιne (800 mg, 4 54 mmol) was dissolved in ethyl alcohol (20 mL), assisted by warming to 60°C The warm solution was treated with galactanc acid (477 mg, 2.27 mmol) in one portion, followed by the dropwise addition of water (0 5 mL) The solution was filtered while hot to remove some insoluble mateπal. The filtrate was allowed to cool to ambient temperature The resulting crystals were filtered, washed with anhydrous diethyl ethei. and dried under vacuum at 40°C to yield 830 mg (65 4%) of an off-white, crystalline powder, mp 141- 143°C Sample No 3 exhibits a log P of 1 924, and such a favorable log P value indicates that the compound has the capability of passing the blood-brain banner The sample exhibits a Ki of 34 nM The low binding constant indicates that the compound exhibits good high affinity binding to certain CNS nicotinic receptors Sample No 3 exhibits an EC o value 01 2600 nM and an E max value of 162% for dopamine release, indicating that the compound effectively induces neurotransmitter release thereby exhibiting know n nicotinic pharmacology The sample exhibits an ECso value of 45 nM and an E ma v alue of 33% in the rubidium ion flux assay, indicating that the compound effectively induces activation of CNS nicotinic receptors Sample No 3 exhibits an E max of 0% (at a concentration of 100 uM) at muscle-type receptors, indicating that the compound does not induce activation of muscle-type receptors. The sample exhibits an E ma of 18% (at a concentration of 100 uM) at ganghomc-type receptors. The compound has the capability to activate human CNS receptors without activating muscle-type and ganghomc-type nicotinic acetylchohne receptors to any significant degree Thus, there is provided a therapeutic window for utilization in the treatment of CNS disorders That is, at certain levels the compound shows CNS effects to a significant degree but does not show undesirable muscle or ganglion effects to any significant degree. EXAMPLE 10 Sample No 4 is (4E)-N-methyl-5-(5-ιsopropoxy-3-pyπdyl)-4-penten- 2-amιne hemigalactarate, which was prepared in accordance with the following techniques- 4-Penten-2-ol p-Toluenesulfonate Under a nitrogen atmosphere, p-toluenesulfonyl chloride (16.92 g, 88.75 mmol) was added to a cold (2°C), stimng solution of 4-penten-2-ol (7.28 g, 84 52 mmol) in pyπdine (60 mL) The solution was stirred at 2-5°C for 2 h and allowed to warm to ambient temperature over several hours. The mixture, containing white solids, was poured into cold 3M HCI solution (250 mL) and extracted with CHC1 3 (4 x 75 mL) The combined CHCL extracts were washed ith 3M HCI solution (4 x 100 mL), saturated NaCl solution (2 x 50 mL), dned (Na 2 SO ), filtered, concentrated on a rotary evaporator, and further dned under high v acuum to afford 17 38 g (85 6%) of a light-amber oil N-Mefhyl-4-penten-2-amιne -30- SUBSTΓTIΠΈ SHEET (RULE 26) A glass pressure tube was charged w ith 4-penten-2-ol p-toluenesulfonate ( 17 30 g, 71 99 mmol) followed bv a 40% solution of aqueous methylamine ( 1 1 1 85 g, 1 44 mol) The tube was sealed, and the mixture was stirred and heated at 122°C for 16 h and allowed to cool to ambient temperature After further cooling to 0-5°C, the light- vellow solution was saturated with solid NaCl and extracted with diethvl ether (6 x 40 mL, inhibitor-free) The combined light-yellow ether extracts were dried (Na 2 SO 4 ) and filtered The ether was removed bv distillation at atmospheric pressure using a 6- inch Vigreaux column and a short-path distillation apparatus The residual ght- yellow oil was distilled at atmospheric pressure collecting 3 72 g (52 1%) of a colorless oil, bp 75-105°C N-Methyl-N-(tert-butoxycarbonyl)-4-penten-2-amιne Di-tert-butyl dicarbonate (6 84 g, 31 35 mmol) was quickly added in several portions to a cold (0-5°C), stirπng solution of N-methyl-4-penten-2-amme (3 66 g, 25 68 mmol) in dry THF (25 mL, freshly distilled from sodium and benzophenone) The resulting light-yellow solution was stirred and allowed to warm to ambient temperature over several hours The solution was concentrated on a rotary evaporator The resulting oil was vacuum distilled using a short-path distillation apparatus, collecting 5 22 g (88 4%) of an almost colorless oil, bp 85-86°C at 5 5 mm Hg 5-Bromo-3-ιsopropoxypyπdιne can be prepared by two different methods (Method A and Method B) as described below 5-Bromo-3-ιsopropoxypyπdιne (Method A) Potassium metal (6 59 g, 168 84 mmol) was dissolved in dry 2-propanol (60 0 mL) under nitrogen The resulting potassium isopropoxide was heated w ith 3,5- dibromopyπdine (20 00 g, 84 42 mmol ) and copper powder ( 1 g 5% bv weight of 3,5-dιbromopyπdιne) at 140°C in a sealed glass tube for 14 h The reaction mixture was cooled to ambient temperature and extracted with diethvl ether (4 \ 200 mL) The combined ether extracts vv ere dried ov er sodium sulfate, filtered, and concentrated by rotary evaporation. The crude product obtained was punfied by column chromatography over aluminum oxide, eluting with ethyl acetate-hexane ( 1 -9, v/v) Selected fractions were combined and concentrated by rotary evaporation, producing a pale-yellow oil (12.99 g, 71.2%). 5-Bromo-3-ιsopropoxypyndιne (Method B) 5-Bromomcotιnamιde Under a nitrogen atmosphere, 5-bromonιcotιnιc acid ( 10 10 g, 50 00 mmol) was dissolved in thionyl chloride (65.24 g, 0 55 mol), and the resulting solution was stirred 45 mm at ambient temperature. Excess thionyl chloride was removed by distillation, and the residue was dned under high vacuum. The resulting solid was ground to a powder with a mortar and pestle under a nitrogen atmosphere and quickly added to a 28% solution of aqueous ammonia at 0°C. The mixture was stirred bnefly at 0°C and then at ambient temperature for 3 h. The crude product was filtered, dned, and recrystalhzed from toluene-ethanol (1 1 , v/v) to give 6 92 g (68.9%) of 5- bromomcotinamide, mp 210-213°C (lit. mp 219-219 5°C, see C. V. Greco et al., J Heteocychc Chem. 7(4)- 761 (1970)). 3-Ammo-5-bromopyndιne Sodium hydroxide (2.50 g, 62.50 mmol) was added to a cold (0°C), stirnng suspension of calcium hypochlonte solution (1.53 g, 7.50 mmol of 70% solution) in water (35 mL). The mixture was stirred 15 min at 0°C and filtered. The clanfied filtrate was cooled and stirred in an ice-salt bath while 5-bromonιcotιnamιde (3.03 g, 15.1 mmol) was added in one portion. The suspension was stirred 2 h at 0°C, warmed to ambient temperature, and heated on a steam bath for 1 h After cooling, the mixture was extracted with CHCh (2 x 50 mL). The combined CHCh extracts were dned (Na 2 S0 ), filtered, and concentrated on a rotary evaporator producing 1 42 g of a light-yellow solid. The aqueous layer was adjusted to pH 8 with 6M HCI solution and extracted with CHCh (2 x 50 mL) The combined CHCh extracts were dned (Na 2 S0 ), filtered, and concentrated on a rotary evaporator, affording 0.98 g of a brown solid. Based upon TLC analysis (toluene-ethanol (3 : 1 , v/v)), both crude products were combined to give 2.40 g which was dissolved in ethanol (10 mL) and filtered to remove a small amount of a light-yellow solid (80 mg, mp 225-227°C). The filtrate was concentrated on a rotary evaporator, and the residue was dissolved in 2- propanol (6 mL), filtered, and cooled to 5°C. The resulting precipitate was filtered and dried to give a small amount of a tan solid (65 mg, mp 63-64°C). The filtrate was concentrated on a rotary evaporator, and the residue was dissolved in toluene (5 mL), assisted by heating, and cooled to 5°C. The resulting precipitate was filtered and dried under vacuum to give 1.80 g of a brown, crystalline solid, mp 65-67°C. By concentrating the filtrate and cooling, a second crop of 0.27 g of a brown solid, mp 64-66°C (lit. mp 69-69.5°C, see C. V. Greco et al., J. Heteocyclic Chem. 7(4): 761 (1970)) was obtained, bringing the total yield to 2.07 g (79.3%). 5-Bromo-3-isopropoxypyridine A slurry of 5-amino-3-bromopyridine (1.29 g, 7.46 mmol) in 6M HCI solution (5 mL) was stirred 30 min at ambient temperature. The mixture was concentrated under high vacuum, and the residue was vacuum dried for 15 h at 50°C, affording a tan solid. The solid was slurried in 2-propanol (25 mL), and treated with isoamyl nitrite (1.70 g, 15.00 mmol). The mixture was stirred and heated under reflux for 1.5 h. The solution was concentrated by rotary evaporation, and the residue was partitioned between diethyl ether and 1M NaOH solution. The aqueous layer was separated and extracted with ether. The combined ether extracts were dried (Na 2 S0 ), filtered, and concentrated by rotary evaporation producing an orange oil (2.03 g). The oil was purified by vacuum distillation, collecting the fraction with bp 105-1 15°C at 9 mm Hg. The distilled product was further purified by column chromatography on silica gel, eluting with 10— 20% (v/v) diethyl ether in hexane. Selected fractions, based upon TLC analysis (R f 0.40 in hexane-ether, (4: 1 , v/v)) were combined and concentrated by rotary evaporation to give 566.0 mg (35.2%) of a clear, colorless oil. -33- SUBSTΓΓUTE SHEET (RULE 26) (4E)-N-Methyl-N-(tert-butoxycarbonyl)-5-(5-ιsopropoxy-3-pyndvl)-4-penten-2- amme Under a nitrogen atmosphere, a mixture of 5-bromo-3-ιsopropoxypyπdιne (847 0 mg, 3 92 mmol), N-methyl-N-(tert-butoxycarbonyl)-4-penten-2-amιne (784 7 mg, 3 94 mmol), palladιum(II) acetate (9 0 mg, 0 04 mmol), tn-o-tolylphosphine (50 0 mg, 0 16 mmol), tnethylamine (0 73 g, 7 21 mmol), and anhydrous acetonitnle (2 mL) was stirred and heated under reflux at 80°C for 20 h The mixture, containing solids was cooled, diluted with water (10 mL), and extracted with CHCh (3 x 10 mL) The combined CHC1 3 extracts were dried (Na?S0 4 ), filtered, and concentrated by rotary evaporation to give an oily residue ( 1 56 g) The crude product was purified by column chromatography on silica gel, eluting with 25→40% (v/v) ethyl acetate in hexane Selected fractions containing the product were combined and concentrated to give 1 15 g (87 8%) of a light-amber oil (4E)-N-Methyl-5-(5-ιsopropoxy-3-pyπdyl)-4-penten-2-amιne Under a nitrogen atmosphere, a cold (0-5°C), stirπng solution of (4E)-N-methyl-N- (tert-butoxycarbonyl)-5-(5-ιsopropoxy-3-pyndyl)-4-penten-2-amιne ( 150 0 mg, 0 45 mmol) in amsole (2.25 mL) was treated with tπfluoroacetic acid (1 49 g, 13 79 mmol) in one portion The resulting solution was stirred for 15 min at 0-5°C TLC analysis on silica gel (EtOAc-hexane (3 1 , v/v) and CH 3 OH-Et 3 N (97 5 2 5, v/v)) indicated almost complete reaction After stirring for an additional 15 min, the solution was concentrated on a rotary evaporator, followed by further drying under vacuum at 0 5 mm Hg to give 278 mg of a dark-yellow oil The oil was cooled (0-5°C), basified with 10% NaOH solution (2 mL) to pH 12, and saturated NaCl solution (5 mL) was added The mixture was extracted with CHCh (5 x 3 mL) The combined CHCh extracts were washed with saturated NaCl solution (5 mL), dned (Na 2 S0 4 ), filtered, concentrated by rotary evaporation, followed by further drying at 0 5 mm Hg to give 104 7 mg of a light-yellow, shghtlv orange oil The crude product w as purified by column chromatography on silica gel (20 g), eluting with CHiOH-EhN ( 100 2, v/v) Selected fractions containing the product (R| 0 37) were combined and concentrated on a rotarv evaporator to afford 72.3 mg of a yellow oil The oil was dissolved in CHCh (25 mL ). and the CHCh solution was dried (Na 2 SO 4 ), filtered, concentrated by rotary evaporation, and vacuum dned to give 69 3 mg (66 2%) of a yellow oil (4E)-N-Methvl-5-(5-ιsopropoxy-3-pyndyl)-4-penten-2-amιne Hemigalactarate (4E)-N-Methvl-5-(5-ιsopropoxy-3-pyπdyl)-4-penten-2-amιne (69 3 mg, 0 23 mmol) was dissolved in CH 3 OH (1.5 mL), assisted by heating The warm solution was treated with galactaπc acid (24.3 mg, 0.12 mmol). followed by water (0 3 mL) The resulting solution was warmed and filtered through glass wool to remove a few insoluble particles, washing the filter plug with 0 4 mL of a CH 3 OH-H 2 0 (4.1 , v/v ) solution The filtrate was diluted with CHiOH ( 1 5 mL), and the light-yellow solution was stored at 5°C for 15 h No precipitate had formed, therefore, the solution was concentrated on a rotary evaporator. The resulting solids were tnturated with anhydrous diethyl ether (3 x 6 mL) The product was dned under a stream of nitrogen, dned under high vacuum, followed by further vacuum drying at 45 °C for 15 h to afford 73 0 mg (93 1 %) of an off-white powder, mp 144-146.5°C Sample No 4 exhibits a log P of 2 957, and such a favorable log P value indicates that the compound has the capability of passing the blood-brain barner The sample exhibits a Ki of 10 nM The low binding constant indicates that the compound exhibits good high affinity binding to certain CNS nicotinic receptors Sample No 4 exhibits an EC 50 value of 100 nM and an E max value of 57% for dopamine release, indicating that the compound effectively induces neurotransmitter release thereby exhibiting known nicotinic pharmacology The sample exhibits an EC 50 value of 100 nM and an E max value of 60% in the rubidium ion flux assay, indicating that the compound effectively induces activ ation of CNS nicotinic receptors Sample No 4 exhibits an E ma of 15% (at a concentration of 100 uM) at muscle-type receptors, indicating that the compound does not significantly induce activation of muscle-type receptors The sample exhibits an E ma of 36% (at a concentration of 100 uM) at ganghomc-type receptors The compound has the capability to activ ate human CNS receptors without activating muscle-type and ganghonic-tv pe nicotinic acetylcho ne receptors to anv significant degree Thus -35- SUBSTΓΓUTE SHEET (RULE 26) there is provided a therapeutic w indow for utilization in the treatment of CNS disorders. That is, at certain lev els the compound shows CNS effects to a significant degree but does not show undesirable muscle and ganglion effects to anv significant degree. The compound begins to cause muscle effects and ganglion effects only when employed in amounts greater than those required to activate rubidium ion flux and dopamine release, thus indicating a lack of undesirable side effects in subjects receiving administration of this compound. EXAMPLE 11 Sample No 5 is (2R)-(4E)-N-methyl-5-(5-ιsopropoxy-3-pyndyl)-4- penten-2-amιne hemigalactarate, which was prepared in accordance with the following techniques: (2S)-4-Penten-2-ol (2S)-4-Penten-2-ol was prepared from (S)-(-)-propylene oxide using a procedure similar to that descπbed for the preparation of (2R)-4-penten-2-ol from (R)-(+)- propylene oxide as detailed in A Kahvretenos, J. K. Stille, and L. S Hegedus, J. Org. Chem 56: 2883 (1991 ). Thus, a 1 0M solution of vinylmagnesium bromide in THF ( 129 mL, 129.0 mmol) was slowly added to a suspension of copper(I) iodide (2.46 g, 12.92 mmol) in dry THF (40 mL. distilled from sodium and benzophenone) at -25°C. After stirπng 5 min, a solution of (S)-(-)-propylene oxide (5 00 g, 86 1 mmol) in dry THF (5 mL) was added. The mixture was allowed to warm to - 10°C and placed in a freezer at 0°C for 12 h. The mixture was stirred for an additional 1 h at 0°C and poured into a mixture of saturated ammonium chloride solution ( 100 mL) and ice (100 g). The mixture was stirred for 4 h and extracted with ether (3 \ 100 mL) The combined ether extracts were dned (K 2 COι), filtered, and concentrated under reduced pressure by rotary evaporation at 0°C The resulting brown oil was vacuum distilled to yield 5 86 g (79 1%) of a colorless distillate, bp 37-39°C at 9 mm Hg (2S)-(4E)-5-(5-Isopropoxy-3-pyndvl)-4-penten-2-ol -36- SUBSTΓΓUTE SHEET (RULE 26) A mixture of 5-bromo-3-ιsopropoxypyπdιne ( 12.56 g, 58.13 mmol), (2S)-4-penten-2- ol (5.00 g, 58.05 mmol), palladιum(II) acetate ( 130 mg, 0.58 mmol), tri-o- tolylphosphme (706 mg, 2.32 mmol), tnethylamine (35 mL, 252 mmol) and acetonitnle (35mL) were heated in a sealed glass tube at 130-140°C for 8 h. The reaction mixture was cooled to ambient temperature. The solvent was removed under reduced pressure on a rotary evaporator. Water (50 mL) was added and the mixture was extracted with chloroform (3 x 50 mL). The combined chloroform extracts were dried (K 2 C0 3 ), filtered, and concentrated by rotary evaporation. The crude product was punfied by column chromatography over silica gel, eluting with chloroform- acetone (95:5, v/v). Selected fractions were combined and concentrated by rotary evaporation, producing 7.80 g (60.7%) of a pale-yellow oil. (2S)-(4E)-5-(5-Isopropoxy-3-pyndyl)-4-penten-2-ol p-Toluenesulfonate Under a nitrogen atmosphere, p-toluenesufonyl chlonde (1 1.45 g, 60.06 mmol) was added to a stimng solution of (2S)-(4E)-5-(5-ιsopropoxy-3-pyridyl)-4-penten-2-ol (7.00 g, 31.63 mmol) in dry triethylamine (30 mL) at 0°C. After stirring and warming to ambient temperature over 18 h, the mixture was concentrated on a rotary evaporator. The crude product was stirred with saturated NaHC0 3 solution (100 mL) for 1 hour and extracted with chloroform (3 x 50 mL). The combined chloroform extracts were dned (K?C0 3 ), filtered, and concentrated by rotary evaporation to afford 10.00 g (84.2%) as a dark-brown oil, which was used without further purification. (2R)-(4E)-N-Methyl-5-(5-ιsopropoxy-3-pyπdyl)-4-penten-2-amιne A mixture of (2S)-(4E)-5-(5-isopropoxy-3-pyπdyl)-4-penten-2-ol p-toluenesulfonate (10.00 g, 26.63 mmol) and methylamine (50 mL, 2.0M solution in THF) was heated at 100°C for 10 h in a sealed glass tube. The mixture was cooled to ambient temperature and concentrated under reduced pressure on a rotary evaporator. The crude product was treated with saturated NaHCOi solution (50 mL) and extracted with chloroform (4 x 50 mL). The combined chloroform extracts were dried (K 2 COι), filtered, and concentrated by rotary evaporation to afford a dark-brown oil (3.50 g). The crude product was punfied by repeated ( tw ice) column chromatography on silica -37- SUBSTΠΓUTE SHEET (RULE 26) gel, eluting with chloro form-methanol (95:5, v/v). Selected fractions were combined, concentrated by rotary evaporation affording a light-brown oil (2.50 g). The oil was further purified by vacuum distillation using a short-path distillation apparatus, collecting 2.05 g (32.9%) of a colorless oil, bp 98-100°C at 0.04 mm Hg. (2R)-(4E)-N-Methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine Hemigalactarate Galactaric acid (314.0 mg, 1.49 mmol) was dissolved in 2-propanol (10 mL) and water (~1 mL), assisted by heating and sonicating over a period of 10 min. A solution of (2R)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine (700.3 mg, 2.99 mmol) in 2-propanol (10 mL) was then added, followed by additional sonicating and heating at 60°C for 10 mm. The hot solution was filtered to remove some insoluble material. The solvent was removed on a rotary evaporator; the resulting light-brown syrup was dissolved in dry 2-propanol (5 mL) and cooled at 4°C. The resulting precipitate was filtered and dried under high vacuum to yield 657 mg (64.8%) of an off-white, crystalline powder, mp 150-153°C. Sample No. 5 exhibits a log P of 2.957, and such a favorable log P value indicates that the compound has the capability of passing the blood-brain barrier. The sample exhibits a Ki of 62 nM. The low binding constant indicates that the compound exhibits good high affinity binding to certain CNS nicotinic receptors. Sample No. 5 exhibits an ECso value of 634 nM and an E max value of 38% for dopamine release, indicating that the compound effectively induces neurotransmitter release thereby exhibiting known nicotinic pharmacology. The sample exhibits an EC50 value of 88 nM and an E m _ x value of 14%) in the rubidium ion flux assay, indicating that the compound induces activation of CNS nicotinic receptors. Sample No. 5 exhibits an E max of 0% (at a concentration of 100 uM) at muscle-type receptors, indicating that the compound does not induce activation of muscle-type receptors. The sample exhibits an E max of 14% (at a concentration of 100 uM) at ganglionic-type receptors. The compound has the capability to activate human CNS receptors without activating muscle-type and ganglionic-type nicotinic acetylcholine receptors to any significant degree. Thus, there is provided a therapeutic window for utilization in the treatment of CNS disorders. That is, at certain levels the compound shows CNS effects to a significant degree but does not show undesirable muscle and ganglia effects to any significant degree. EXAMPLE 12 Sample No. 6 is (2S)-(4E) -N-methyl-5-(5-ιsopropoxy-3-pyndyl)-4- penten-2-amιne hemigalactarate, which was prepared in accordance with the following techniques: (2R)-4-Penten-2-ol (2R)-4-Penten-2-ol was prepared in 82.5% yield from (R)-(+)-propylene oxide according to procedures set forth in A. Kahvretenos, J. K. Stille, and L. S. Hegedus, J Org Chem. 56: 2883 (1991). (2R)-(4E)-5-(5-Isopropoxy-3-pyπdyl)-4-penten-2-ol A mixture of 5-bromo-3-isopropoxypyπdme (10.26 g, 47.50 mmol), (2R)-4-penten-2- ol (4.91 g, 57.00 mmol), palladιum(II) acetate (106 mg, 0.47 mmol), tπ-o- tolylphosphine (578 mg, 1.90 mmol), tnethylamine (28.46 mL, 204.25 mmol), and acetonitnle (30 mL) were heated in a sealed glass tube at 140°C for 14 h. The reaction mixture was cooled to ambient temperature, diluted with water, and extracted with chloroform (3 x 200 mL). The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation to give a pale-yellow oil (8.92 g, 85.0%). (2R)-(4E)-5-(5-Isopropoxy-3-pyndyl)-4-penten-2-ol p-Toluenesulfonate To a stirred solution of (2R)-(4E)-5-(5-ιsopropoxy-3-pyπdyl)-4-penten-2-ol (8.50 g, 38.46 mmol) in dry pyndine (30 mL) at 0°C was added p-toluenesulfonyl chloride ( 14.67 g, 76.92 mmol) The reaction mixture was stirred for 24 h at ambient temperature. The pyndine was removed by rotary evaporation. Toluene (50 mL) was added to the residue and removed by rotary evaporation. The crude product was stirred with a saturated solution of sodium bicarbonate (100 mL) and extracted with chloroform (3 x 100 mL). The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation to yield a dark-brown, viscous (2S)-(4E)-N-Methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine A mixture of (2R)-(4E)-5-(5-isopropoxy-3-pyridyl)-4-penten-2-ol p-toluenesulfonate (1 1.00 g, 29.33 mmol), methylamine (200 mL, 40% solution in water), and ethyl alcohol (10 mL) was stirred at ambient temperature for 18 h. The resulting solution was extracted with chloroform (3 x 100 mL). The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation. The crude product was purified by column chromatography over aluminum oxide, eluting with ethyl acetate-methanol (7:3, v/v). Selected fractions were combined and concentrated by rotary evaporation, producing an oil. Further purification by vacuum distillation furnished 2.10 g (31.0%) of a colorless oil, bp 90-100°C at 0.5 mm Hg. (2S)-(4E)-N-Methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine.Hemigalactarate (2S)-(4E)-N-Methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine (2.00 g, 8.55 mmol) was dissolved in ethyl alcohol (20 mL), assisted by warming to 70°C. The warm solution was treated with galactaπc acid (900 mg, 4.27 mmol) in one portion, followed by the dropwise addition of water (0.5 mL). The solution was filtered while hot to remove some insoluble material. The filtrate was allowed to cool to ambient temperature. The resulting crystals were filtered, washed with anhydrous diethyl ether, and dried under vacuum at 40°C to yield a white, crystalline powder (750 mg, 26.0%), mp 140-143°C. Sample No. 6 exhibits a log P of 2.957, and such a favorable log P value indicates that the compound has the capability of passing the blood-brain barπer. The sample exhibits a Ki of 1 1 nM. The low binding constant indicates that the compound exhibits good high affinity binding to certain CNS nicotinic receptors. Sample No. 6 exhibits an ECso value of 106 nM and an E max value of 85% for dopamine release, indicating that the compound effectively induces neurotransmitter -40- SUBSTΓΓIΠΈ SHEET (RULE 26) release thereby exhibiting known nicotinic pharmacology The sample exhibits an ECso value of 220 nM and an E mi χ \ alue of 58% in the rubidium ion flux assay, indicating that the compound effectively induces activation of CNS nicotinic receptors Sample No 6 exhibits an E ma of 0% (at a concentration of 100 uM) at muscle-type receptors, indicating that the compound does not induce activation of muscle-type receptors The sample exhibits an E max of 0% (at a concentration of 100 uM) at ganghomc-type receptors The compound has the capability to activate human CNS receptors without activating muscle-type and ganghomc-type nicotinic acetylcholme receptors to any significant degree Thus, there is provided a therapeutic window for utilization in the treatment of CNS disorders That is, at certain levels the compound show s CNS effects to a significant degree but does not show undesirable muscle or ganglia effects to any significant degree EXAMPLE 13 Sample No 7 is (4E)-N-mefhyl-5-(5-bromo-3-pyπdyl)-4-penten-2- amme, which was prepared in accordance with the following techniques (4E)-5-(5-Bromo-3-pyndyl)-4-penten-2-ol A mixture of 3,5-dιbromopyndιne (23 60 g, 100 0 mmol), 4-penten-2-ol ( 10 8 g, 125 0 mmol), palladιum(II) acetate (230 mg, 1 02 mmol), tπ-o-tolvlphosphme (1.20 g, 3 94 mmol), tnethylamine (29 7 mL, 213 45 mmol), and acetonitnle (40 mL) were heated m a sealed glass tube at 140°C for 14 h The reaction mixture w as cooled to ambient temperature, diluted with water, and extracted with chloroform (3 x 200 mL) The combined chloroform extracts were dned over sodium sulfate and filtered Removal of solvent by rotarv evaporation, followed by column chromatography over silica gel eluting with acetone-chloroform ( 1 9, v/v) furnished 8 10 g (34 0%) of a pale-yellow oil (4E)-N-Methyl-5-(5-bromo-3-pvπdyl)-4-penten-2-amιne -41- SUBSTΓΓUTE SHEET (RULE 26) To a stimng solution of (4E)-5-(5-bromo-3-pyπdyl)-4-penten-2-ol (3.14 g, 13.0 mmol) in dry pyndine (30 mL) at 0°C was added p-toluenesulfonyl chloride (3.71 g, 19.5 mmol). The reaction mixture was stirred for 24 h at ambient temperature. The pyridine was removed by rotary evaporation. Toluene (50 mL) was added to the residue and subsequently removed by rotary evaporation. The crude product was stirred with a saturated solution of sodium bicarbonate ( 100 mL) and extracted with chloroform (3 x 100 mL). The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation to give (4E)-5-(5-bromo-3- pyridyl)-4-penten-2-ol p-toluenesulfonate. The resulting tosylate was treated with excess methylamine (40% solution in water), ethyl alcohol (10 mL), and stirred at ambient temperature for 18 h. The resulting solution was extracted with chloroform (3 x 100 mL). The combined chloroform extracts were dried over sodium sulfate and filtered. Removal of solvent by rotary evaporation followed by column chromatography over silica gel eluting with chloro form-methanol (95:5, v/v) produced 1.50 g (45.0%) of a pale-yellow oil. Sample No. 7 exhibits a log P of 2.026, and such a favorable log P value indicates that the compound has the capability of passing the blood-brain barrier. The sample exhibits a Ki of 284 nM, indicating that the compound exhibits binding to certain CNS nicotinic receptors. Sample No. 7 exhibits an EC 50 value of 202 nM and an E max value of 18% for dopamine release, indicating that the compound induces neurotransmitter release thereby exhibiting known nicotinic pharmacology. The sample exhibits an E max value of 0% in the rubidium ion flux assay, indicating that the compound exhibits selective effects at certain CNS nicotinic receptors. Sample No. 7 exhibits an E max of 6% (at a concentration of 100 uM) at muscle-type receptors, indicating that the compound does not induce activation of muscle-type receptors. The sample exhibits an E max of 8%> (at a concentration of 100 uM) at ganglionic-type receptors. The compound has the capability to activate human CNS receptors without activating muscle-type and ganglionic-type nicotinic acetylcholine receptors to any significant degree. Thus, there is provided a therapeutic window for utilization in the treatment of CNS disorders. That is, at certain levels the compound shows CNS effects to a significant degree but does not show undesirable muscle or ganglia effects to any significant degree. EXAMPLE 14 Sample No. 8 is (4E)-N-methyl-5-(5-methoxy-3-pyndyl)-4-penten-2-amιne hemigalactarate, which was prepared in accordance with the following techniques: 5-Bromo-3-methoxypyπdιne A mixture of 3,5-dibromopyπdιne (20.00 g, 84.42 mmol), sodium methoxide ( 1 1.40 g, 21 1.06 mmol), and copper powder ( 1 g, 5% by weight of 3,5-dιbromopyndine) in dry methanol was heated in a sealed glass tube at 150°C for 14 h. The reaction mixture was cooled to ambient temperature and extracted with diethyl ether (4 x 200 mL). The combined ether extracts were dned over sodium sulfate, filtered, and concentrated by rotary evaporation. The crude product was punfied by column chromatography over aluminum oxide, eluting with ethyl acetate-hexane ( 1 .9, v/v). Selected fractions were combined and concentrated by rotary evaporation, producing 9.40 g (59.5%) of a colorless oil. which tended to crystallize upon cooling. (4E)-5-(5-Methoxy-3-pyπdyl)-4-penten-2-ol A mixture of 5-bromo-3-methoxypyπdιne (4.1 1 g, 21.86 mmol), 4-penten-2-ol (2.25 g, 26.23 mmol), palladιum(II) acetate (49 mg, 0.22 mmol), tπ-o-tolylphosphme (266 mg, 0.87 mmol), tnethylamine ( 13 71 mL, 98.37 mmol), and acetonitnle ( 15 mL) were heated in a sealed glass tube at 140°C for 14 h. The reaction mixture was cooled to ambient temperature, diluted with water, and extracted with chloroform (3 x 200 mL). The combined chloroform extracts were dried over sodium sulfate. filtered, and concentrated by rotary evaporation to give 3.53 g (70.3%) of a pale-yellow oil. (4E)-5-(5-Methoxy-3-pyπdyl)-4-penten-2-ol p-Toluenesulfonate To a stirred solution of (4E)-5-( 5-methoxy-3-pyπdyl)-4-penten-2-ol (3 50 g. 18.13 mmol) in dry pyndine ( 15 mL ) at 0°C w as added p-toluenesulfonvl chloride (6.91 g, 36.27 mmol). The reaction mixture w as stined for 24 h at ambient temperature. The pyndine was removed by rotarv evaporation. Toluene (50 mL) w s added to the residue and subsequently removed by rotary evaporation. The crude product was stirred with a saturated solution of sodium bicarbonate ( 100 mL) and extracted with chloroform (3 x 100 mL) The combined chloroform extracts were dned over sodium sulfate, filtered, and concentrated by rotary evaporation to give 5.25 g (83.5%) of a dark-brown, viscous oil (4E)-N-Methyl-5-(5-methoxy-3-pyndyl)-4-penten-2-amιne A mixture of (4E)-5-(5-methoxy-3-pyπdyl)-4-penten-2-ol p-toluenesulfonate (5.00 g, 14 41 mmol), methylamine (150 mL, 40% solution in water), and ethyl alcohol (10 mL) was stirred at ambient temperature for 18 h The resulting solution was extracted with chloroform (3 x 100 mL). The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation. The crude product was purified by column chromatography over aluminum oxide, eluting with ethyl acetate-methanol (7:3, v/v). Selected fractions were combined and concentrated by rotary evaporation, producing an oil. Further purification by vacuum distillation furnished 1.25 g (41.8%) of a colorless oil, bp 90-100°C at 0.5 mm Hg. (4E)-N-Methyl-5-(5-methoxy-3-pyπdyl)-4-penten-2-arnme Hemigalactarate (4E)-N-Methyl-5-(5-methoxy-3-pyndyl)-4-penten-2-amιne ( 1.20 g, 5.83 mmol) was dissolved in ethyl alcohol (20 mL), assisted by warming to 60°C. The warm solution was treated with galactanc acid (610 mg, 2.91 mmol) in one portion, followed by dropwise addition of water (0.5 mL) The solution was filtered while hot to remove some insoluble mateπal The filtrate was allowed to cool to ambient temperature. The resulting crystals were filtered, washed ith anhydrous diethyl ether, and dried under vacuum at 40°C to yield 1.05 g (58.0%) of a white, crystalline powder, mp 143- 145°C. Sample No. 8 exhibits a log P of 2.025, and such a favorable log P value indicates that the compound has the capability of passing the blood-brain barπer The sample exhibits a Ki of 22 nM. The low binding constant indicates that the compound exhibits good high affinity binding to certain CNS nicotinic receptors. -44- SUBSTΓΓUTE SHEET (RULE 26) Sample No. 8 exhibits an ECso value of 5000 nM and an E max value of 1 10% for dopamine release, indicating that the compound effectively induces neurotransmitter release thereby exhibiting known nicotinic pharmacology Sample No. 8 exhibits an E max of 10% (at a concentration of 100 uM) at muscle-type receptors, indicating that the compound does not induce activation of muscle-type receptors. The sample exhibits an E max of 2% (at a concentration of 100 uM) at ganglionic-type receptors The compound has the capability to activate human CNS receptors without activating muscle-type and ganghomc-type nicotinic acetylcholine receptors to any significant degree. Thus, there is provided a therapeutic window for utilization in the treatment of CNS disorders. That is, at certain levels the compound shows CNS effects to a significant degree but do not show undesirable muscle or ganglion effects to any significant degree EXAMPLE 15 Sample No. 9 is (4E)-N-methyl-5-(5-ethoxy-3-pyndyl)-4-penten-2-amιne hemigalactarate, which was prepared in accordance with the following techniques. 5-Bromo-3-ethoxypyπdιne Under a nitrogen atmosphere, sodium (4.60 g, 200.0 mmol) was added to absolute ethanol (100 mL) at 0-5°C, and the stirring mixture was allowed to warm to ambient temperature over 18 h. To the resulting solution was added 3,5-dιbromopyπdιne (31.50 g, 133.0 mmol), followed by DMF ( 100 mL). The mixture was heated at 70°C for 48 h. The brown mixture was cooled, poured into water (600 mL), and extracted with ether (3 x 500 mL). The combined ether extracts were dned (Na 2 S0 ), filtered, and concentrated by rotary evaporation, producing 46.70 g of an oil. Purification by vacuum distillation afforded 22.85 g (85.0%) of an oil, bp 89-90°C at 2.8 mm Hg, (lit bp 1 1 1 °C at 5 mm Hg, see K. Clarke et al., J Chem Soc 1885 ( I 960)) (4E)-N-Methyl-N-(tert-butoxycarbonyl)-5-(5-ethoxy-3-pyndyl)-4-penten-2-amιne Under a nitrogen atmosphere, a mixture of 5-bromo-3-ethoxypyπdιne ( 1.20 g. 5 94 mmol), N-methyl-N-(tert-butoxycarbonyl)-4-penten-2-amιne ( 1 18 g, 5 94 mmol), palladιum(II) acetate (13 5 mg, 0 06 mmol), tn-o-tolylphosphine ( 73 1 mg, 0 24 mmol), tnethylamine (1 5 mL. 10 8 mmol), and anhydrous acetonitnle (3 mL) was stirred and heated under reflux at 80-85°C for 28 h The resulting mixture, containing beige solids, was cooled to ambient temperature, diluted with water (20 mL), and -> extracted with CHC1 (3 x 20 mL) The combined light-yellow CHCh extracts were dned (Na 2 S0 4 ), filtered, concentrated by rotary evaporation, and vacuum dried producing a yellow oil (1 69 g) The crude product was punfied by column chromatography on silica gel ( 100 g), eluting with ethyl acetate-hexane ( 1 1, v/v) Selected fractions containing the product (R f 0 20) were combined, concentrated by0 rotary evaporation, and the residue was vacuum dned to give 0 67 g (35 2%) of a light-yellow oil (4E)-N-Methyl-5-(5-ethoxy-3-pyπdyl)-4-penten-2-amιne 5 Under a nitrogen atmosphere, a cold (0-5°C), stimng solution of (4E)-N-methyl-N- (tert-butoxycarbonyl)-5-(5-ethoxy-3-pyπdyl)-4-penten-2-amιne (0 67 g, 2 09 mmol) in amsole (10 mL) was treated dropwise over 30 min with tπfluoroacetic acid ( 10 40 g, 91 17 mmol). The resulting solution was stirred for 45 mm at 0-5°C and was then concentrated by rotary evaporation The light-yellow oil was further dried under high0 vacuum at 0 5 mm Hg The resulting oil was cooled (0-5°C), basified with 10% NaOH solution (10 mL), treated with saturated NaCl solution (7 5 mL). and extracted with CHC1 3 (4 x 10 mL) The combined light-yellow CHCh extracts were washed with saturated NaCl solution (20 mL), dried (Na 2 S0 ), filtered, concentrated by rotary evaporation, followed by further drying at 0 5 mm Hg producing a brown oil (0 46 g)5 The crude product was purified by column chromatography on silica gel (56 g), eluting with CH 3 0H-Et 3 N (98 2, v/v) Selected fractions containing the product (R f 0 35) were combined and concentrated on a rotary evaporator The residue was dissolved in CHCh, and the CHCh solution was dried (Na 2 Sθ4), filtered. concentrated by rotary evaporation, and vacuum dned to give 32 7 5 mg (71 0%) of a0 light-yellow oil (4E)-N-Methyl-5-(5-ethoxv-3-pvπdyl)-4-penten-2-amιne Hemigalactarate To a solution of (4E)-N-methyl-5-(5-ethoxy-3-pvπdyl)-4-penten-2-amme ( 151 4 mg, 0.68 mmol) in absolute ethanol (2.3 mL) was added galactaπc acid (72.2 mg, 0.34 mmol) Water (ϋ 5 mL) was added dropwise while gently warming the light-brown solution The solution was filtered through glass wool to remove a few insoluble particles, washing the filter plug with ethanol-water (4 1 , v/v) ( 1 mL). The filtrate was diluted with ethanol (3 4 mL), cooled to ambient temperature, and further cooled at 5°C for 18 h Because no precipitate had formed, the solution was concentrated on a rotary evaporator The resulting solids were dried under high vacuum and recrystalhzed from 2-propanol-water. After cooling at 5°C for 48 h the product was filtered, washed with cold 2-propanol, and vacuum dried at 45°C for 6 h. Further vacuum drying at ambient temperature for 18 h afforded 168 mg (76.1%) of a white to off-white powder, mp 141 -143.5°C Sample No 9 exhibits a log P of 2.556, and such a favorable log P value indicates that the compound has the capability of passing the blood-brain barner. The sample exhibits a Ki of 15 nM. The low binding constant indicates that the compound exhibits good high affinity binding to certain CNS nicotinic receptors. Sample No 9 exhibits an ECso value of 520 nM and an E max value of 85% for dopamine release, indicating that the compound effectively induces neurotransmitter release thereby exhibiting known nicotinic pharmacology The sample exhibits an E max value of 0% in the rubidium ion flux assay, indicating that the compound exhibits selective effects at certain CNS nicotinic receptors Sample No 9 exhibits an E max of 21 % (at a concentration of 100 uM) at muscle-type receptors, indicating that the compound does not induce activation of muscle-type receptors The sample exhibits an E mJ of 9% (at a concentration of 100 uM) at ganghomc-type receptors. The compound has the capability to activate human CNS receptors without activating muscle-type and ganghomc-type nicotinic acetylchohne receptors to any significant degree Thus, there is provided a therapeutic window for utilization in the treatment of CNS disorders. That is, at certain levels the compound shows CNS effects to a significant degree but does not show undesirable muscle or ganglia effects to anv significant degree. EXAMPLE 16 Sample No. 10 is (4E)-N-methyl-5-(6-amιno-5-methyl-3-pyπdyl)-4-penten-2- amine, which was prepared in accordance with the following techniques: (4E)-N-Methyl-N-(tert-buto\ycarbonyl)-5-(6-amιno-5-methyl-3-pyπdyl)-4-penten-2- amine A mixture of 2-amιno-5-bromo-3-methylpyridine ( 1.41 g, 7.53 mmol), N-methyl-N- (tert-butoxycarbonyl)-4-penten-2-amιne ( 1.50 g, 7.53 mmol), palladιum(II) acetate (33.8 mg, 0.15 mmol), tπ-o-tolylphosphine (183.2 mg, 0.60 mmol), tnethylamine (4.50 mL, 32.3 mmol), and anhydrous acetonitrile (8 mL) was stined and heated at 130-132°C in a sealed glass tube for 18 h. The mixture was further heated at 140°C for 84 h. The resulting dark-brown solution was cooled to ambient temperature and concentrated by rotary evaporation The residue was diluted with water (25 mL) and extracted with CH 2 C1 2 (3 x 25 mL). The combined CH C1 2 extracts were dned (Na 2 S0 4 ), filtered, concentrated by rotary evaporation, and vacuum dried producing a dark-brown oil (2.84 g). The crude product was purified by column chromatography on silica gel (135 g), eluting with ethyl acetate-hexane (3: 1 , v/v) to remove impurities, followed by elution with CH^OH-Et 3 N (98:2, v/v) to collect the product. Fractions containing the product (R| 0 70) were combined and dissolved in CHCh. The CHC1 3 solution was dried (Na Sθ 4 ), filtered, concentrated by rotary evaporation, and vacuum dned to give 1.1 1 g (48 4%) of an amber-brown oil. (4E)-N-Methyl-5-(6-amιno-5-methyl-3-pyndyl)-4-penten-2-amιne Under a nitrogen atmosphere, tπfluoroacetic acid (17.76 g, 155.76 mmol) was added dropwise, via addition funnel, over 30 min to a cold (0-5°C), stimng solution of (4E)- N-methyl-N-(tert-butoxycarbonyl)-5-(6-amιno-5-methyl-3-pyπdyl)-4-penten-2-amιne ( 1.1 1 g, 3.47 mmol) in amsole ( 15 mL). The resulting solution was stined for 45 min at 0-5°C and was then concentrated by rotary evaporation. The viscous, brown oil was further dried under high vacuum for 18 h. The crude product was cooled (0-5°C), basified with 10% NaOH solution ( 10 mL), treated with saturated NaCl solution ( 10 mL), and extracted with CHCh, (5 \ 10 mL). The combined CHCh extracts were dried (Na 2 S0 ), filtered, concentrated bv rotary evaporation, followed by further drying under high vacuum yielding a dark-brown oil. The crude product was punfied by column chromatography on silica gel (50 g), eluting with CHCl -CH OH-EhN (4: 1 : 1 , v/v/v). Selected fractions containing the product (R f 0.13) were combined and concentrated by rotary evaporation, and the residue was re-chromatographed on silica gel (50 g) eluting with CHC1 -CH 0H (7:3, v/v). Fractions containing the product (R f 0.12) were combined and concentrated by rotary evaporation. The residue was dissolved in CHCh, and the CHC1 3 solution was dned (Na 2 S0 4 ), filtered, concentrated by rotary evaporation, and vacuum dned affording a yellow oil (0.087 g) which tended to crystallize. The semi-crystalline matenal was dissolved in a warm solution of hexane containing a small amount of ethyl acetate. The warm solution was decanted from an insoluble gum. The solution was allowed to cool to ambient temperature and was further cooled at 5°C for 18 h. The resulting crystalline solids were collected, washed with hexane, and vacuum dned at 40°C for 16 h. The yield was 30.8 mg (4.3%>) of a light-yellow powder, mp 78-81°C. Sample No. 10 exhibits a log P of 1.333, and such a favorable log P value indicates that the compound has the capability of passing the blood-brain bamer. The sample exhibits a Ki of 720 nM. The binding constant indicates that the compound exhibits high affinity binding to certain CNS nicotinic receptors. Sample No. 10 exhibits an EC 50 value of 100000 nM and an E max value of 200%) for dopamine release, indicating that the compound induces neurotransmitter release thereby exhibiting known nicotinic pharmacology. Sample No. 10 exhibits an E max of 0%> (at a concentration of 100 uM) at muscle-type receptors, indicating that the compound does not induce activation of muscle-type receptors. The sample exhibits an E ma χ of 0% (at a concentration of 100 uM) at ganglionic-type receptors. The compound has the capability to activate human CNS receptors without activating muscle-type and ganghomc-type nicotinic acetylcholme receptors to any significant degree. Thus, there is provided a therapeutic window for utilization in the treatment of CNS disorders. EXAMPLE 17 Sample No. 1 1 is (4E)-N-methyl-5-(5-pyπmιdιnyl)-4-penten-2-amιne hemigalactarate. which was prepared in accordance with the following techniques: -49- SUBSTΓΓUTE SHEET (RULE 26) (4E)-N-Methyl-N-(tert-butoxycarbonyl)-5-(5-pyπmιdιnyl)-4-penten-2-ol A glass pressure tube was charged with a mixture of 5-bromopynmιdιne ( 1 28 g, 8.05 mmol), N-methyl-N-(tert-butoxycarbonyl)-4-penten-2-amιne ( 1 60 g, 8.05 mmol), palladιum(II) acetate (18 1 mg, 0.08 mmol), tπ-o-tolylphosphine (98.6 mg, 0.32 mmol), tnethylamine (3 00 mL, 21.5 mmol), and anhydrous acetonitnle (6 mL). The tube was flushed with nitrogen and sealed. The mixture was stirred and heated at 90°C for 64 h, followed by further heating at 1 10°C for 24 h The resulting brown mixture was cooled to ambient temperature and concentrated by rotary evaporation. The brown residue was diluted with water (25 mL) and extracted with CH 2 C1 2 (3 x 25 mL). The combined CH 2 C1 2 extracts were dned (Na S0 4 ), filtered, concentrated by rotary evaporation, and vacuum dned producing a dark-brown oil (2.24 g). The crude product was purified by column chromatography on silica gel (120 g), eluting with ethyl acetate-hexane (3.1 , v/v). Fractions containing the product (Rf 0.21 ) were combined, concentrated by rotary evaporation, and vacuum dned to give 1.05 g (46.9%) of a hght-yellow oil (4E)-N-Methyl-5-(5-pynmιdιnyl)-4-penten-2-ol Under a nitrogen atmosphere, a stimng solution of (4E)-N-methyl-N-(tert- butoxycarbonyl)-5-(5-pyπmιdιnyl)-4-penten-2-ol (881.2 mg, 3 18 mmol) in CHC1 3 (55 mL) was treated dropwise at ambient temperature with lodotπmethylsilane (1.41 g, 7.03 mmol). The resulting solution was stirred for 30 min. Methanol (55 mL) was added, and the solution was stirred for an additional 1 h and was concentrated by rotary evaporation. With ice-bath cooling, the residue was basified with 10% NaOH solution (10 mL), treated with saturated NaCl solution ( 10 mL), and extracted with CHC1 3 (8 x 10 mL). The combined CHCh extracts were dned (Na 2 S0 4 ), filtered, concentrated by rotary evaporation, followed by further drying under high vacuum producing a light-brown oil (0 50 g) The crude product was punfied by column chromatography on silica gel (50 g), eluting with CH OH-NH 4 OH (20 1 , v/v) Fractions containing the product (R f 0 43) were combined, concentrated by rotary evaporation, and the residue was dissolved in CHCh. The CHCh solution was dned (Na 2 S0 4 ), filtered, concentrated bv rotarv evaporation, and vacuum dried affording 306 4 mg (54 4%) of a light-amber oil (4E)-N-Methyl-5-(5-pyπmιdιnyl)-4-penten-2-amιne Hemigalactarate To a warm solution of (4E)-N-methyl-5-(5-pynmιdιnyl)-4-penten-2-amιne (258 6 mg, 1 46 mmol) in absolute ethanol (2 3 mL) was added galactaπc acid (153 3 mg, 0 73 mmol) Water (0 8 mL) was added, and the solution was heated to near reflux until most of the solids dissolved The solution was filtered through glass wool to remove a few white, insoluble particles, w ashing the filter plug with a warm solution of ethanol-water (4 1, v/v) (1 1 mL) The filtrate was diluted with ethanol (6 5 mL), cooled to ambient temperature, and further cooled at 5°C for 48 h The white precipitate was filtered, washed with cold ethanol, and vacuum dned at 40°C for 18 h The yield was 390 6 mg (94 8%) of a fluffy, white, crystalline powder, mp 164- 167°C Sample No 11 is determined to exhibit a log P of 0 571, and such a favorable log P value indicates that the compound has the capability of passing the blood-brain barner The sample exhibits a Ki of 179 nM The low binding constant indicates that the compound exhibits good high affinity binding to certain CNS nicotinic receptors Sample No 1 1 exhibits an EC-, 0 value of 1500 nM and an E ma value of 80% for dopamine release, indicating that the compound effectively induces neurotransmitter release therebv exhibiting known nicotinic pharmacology The sample exhibits an EC 50 value of 100000 nM and an E max value of 0%> in the rubidium ion flux assay, indicating that the compound exhibits selective effects at certain CNS nicotinic receptors Sample No 1 1 exhibits an E ma of 0% > (at a concentration of 100 uM) at muscle-type receptors, indicating that the compound does not induce activation of muscle-type receptors The sample exhibits an E max of 13% (at a concentration of 100 uM) at ganglionic-type receptors The compound has the capability to activate human CNS receptors without activating muscle-type and ganglionic-type nicotinic acetylchohne receptors to any significant degree Thus, there is provided a therapeutic window for utilization in the treatment of CNS disorders -51 - SUBSTΓΓUTE SHEET (RULE 26) The foregoing is illustrative of the present invention and is not to be construed as limiting thereof. The invention is defined by the following claims, with equivalents of the claims to be included therein. •51 /1 -

Claims: THAT WHICH IS CLAIMED: 1 . A method for treating a disorder comprising administering to a subject in need thereof, an effective amount of a compound of the formula: where X is carbon or nitrogen bonded to a substituent species characterized as having a sigma m value greater than 0 or less than 0; X' is nitrogen characterized as having a sigma m valve greater than 0 or less than 0; A, A' and A" individually are substituent species characterized as having a sigma m value greater than 0, less than 0 or 0; m is an integer and n is an integer such that the sum of m plus n is 1 , 2, 3, 4, 5, 6, 7, or 8; E 1 , E". E'", E' v , E v and E vι individually represent hydrogen, lower alkyl or halo substituted lower alkyl, such that at least one of E', E", E IM , E ιv , E v and E vι is not hydrogen; Z' and Z" individually are hydrogen or lower alkyl; and the wavy line in the structure indicates that the compound can have a cis (Z) or trans (E) form. 2. The method of Claim 1 whereby the compound has the trans (E) form. 3. The method of Claim 1 whereby A is hydrogen. 4. The method of Claim 1 whereby A, A' and A" are all hydrogen. 5. The method of Claim 1 whereby 1 or 2 of the substituents designated as E 1 , E", E 1 ", E ιv , E v and E vι are non-hydrogen substituents. 6. The method of Claim 1 whereby m plus n is 2 or 3. -52- 7. The method of Claim 1 whereby at least one of Z' and Z" are hydrogen. 8. The method of Claim 1 whereby Z' is hydrogen and Z" is methyl. 9. The method of Claim 1 whereby the compound is selected from the group consisting of (4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N- methyl-5-(5-pyrimidinyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3- pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(6-amino-5-methyl-3-pyridyl)-4- penten-2 -amine, (2R)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (2R)-(4E)- N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5- bromo-3-pyridyl)-4-penten-2 -amine, (4E)-N-methyl-5-(5-ethoxy-3-pyridyl)-4- penten-2-amine, (2S)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N- methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine, and (2S)-(4E)-N-methyl-5- (5-isopropoxy-3-pyridyl)-4-penten-2-amine. 10. A compound of the formula: where X is carbon or nitrogen bonded to a substituent species characterized as having a sigma m value greater than 0 or less than 0; X' is nitrogen characterized as having a sigma m valve greater than 0 or less than 0; A, A' and A" individually are substituent species characterized as having a sigma m value greater than 0, less than 0 or 0; m is an integer and n is an integer such that the sum of m plus n is 1 , 2, 3, 4, 5, 6, 7, or 8; E 1 , E", E" 1 , E ιv , E v and E vι -53- individually represent hydrogen, lower alkyl or halo substituted lower alkyl, such that at least one of E 1 , E", E 1 ", E ιv , E v and E vι is not hydrogen; Z' and Z" individually are hydrogen or lower alkyl; and the wavy line in the structure indicates that the compound can have a cis (Z) or trans (E) form. 1 1 . The compound according to Claim 10 wherein the compound has the trans (E) form. 12. The compound according to Claim 10 wherein A is hydrogen. 13. The compound according to Claim 10 wherein A, A' and A" are all hydrogen. 14. The compound according to Claim 10 wherein 1 or 2 of the substituents designated as E 1 , E", E 1 ", E ι , E v and E vι are non-hydrogen substituents. 1 5. The compound according to Claim 10 wherein m plus n is 2 or 3. 16. The compound according to Claim 10 wherein at least one of Z' and Z" are hydrogen. 1 7. The compound according to Claim 10 wherein Z' is hydrogen and Z" is methyl. 18. The compound according to Claim 10 selected from the group consisting of (4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5- pyrimidinyl)-4-penten-2 -amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4- penten-2-amine, (4E)-N-methyl-5-(6-amino-5-methyl-3-pyridyl)-4-penten-2- amine, (2R)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl- 5-(5-isopropoxy-3-pyridyl)-4-penten-2 -amine, (4E)-N-methyl-5-(5-bromo-3- -54- pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-ethoxy-3-pyridyl)-4-penten-2- amine, (2S)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5- isopropoxy-3-pyridyl)-4-penten-2-amine, and (2S)-(4E)-N-methyl-5-(5- isopropoxy-3-pyridyl)-4-penten-2-amine. 19. A pharmaceutical composition comprising a compound according to any one of Claims 10-18, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier. 20. The use of a compound according to any one of claims 10-18 for the preparation of a medicament for the prevention or treatment of a central nervous systems disorder. -55-

Inventors: BENCHERIF MEROUANE, BHATTI BALWINDER SINGH, CALDWELL WILLIAM SCOTT, CROOKS PETER ANTHONY, DULL GARY MAURICE, HADIMANI SRISHAILKUMAR B, LIPPIELLO PATRICK MICHAEL, PARK HAEIL, WAGNER JARED MILLER, BENCHERIF, MEROUANE, BHATTI, BALWINDER, SINGH, CALDWELL, WILLIAM, SCOTT, CROOKS, PETER, ANTHONY, DULL, GARY, MAURICE, HADIMANI, SRISHAILKUMAR, B., LIPPIELLO, PATRICK, MICHAEL, PARK, HAEIL, WAGNER, JARED, MILLER
Applicants: BENCHERIF MEROUANE, BHATTI BALWINDER SINGH, CALDWELL WILLIAM SCOTT, CROOKS PETER ANTHONY, DULL GARY MAURICE, HADIMANI SRISHAILKUMAR B, LIPPIELLO PATRICK MICHAEL, PARK HAEIL, REYNOLDS TOBACCO CO R, WAGNER JARED MILLER, BENCHERIF, MEROUANE, BHATTI, BALWINDER, SINGH, CALDWELL, WILLIAM, SCOTT, CROOKS, PETER, ANTHONY, DULL, GARY, MAURICE, HADIMANI, SRISHAILKUMAR, B., LIPPIELLO, PATRICK, MICHAEL, PARK, HAEIL, R.J. REYNOLDS TOBACCO COMPANY, WAGNER, JARED, MILLER
Application year: 1999
Main classification: C07D213
IPC codes: A61K31, A61P1, A61P25, C07D213, C07D239