SULFONAMIDE DERIVATIVES

Abstract: The present invention provides certain sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.

Description: SULFONAMIDE DERIVATIVES The present invention relates to the potentiation of glutamate receptor function using certain sulfonamide derivatives. It also relates to novel sulfonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them. In the mammalian central nervous system (CNS), the transmission of nerve impulses is controlled by the interaction between a neurotransmitter, that is released by a sending neuron, and a surface receptor on a receiving neuron, which causes excitation of this receiving neuron. L-Glutamate, which is the most abundant neurotransmitter in the CNS, mediates the major excitatory pathway in mammals, and is referred to as an excitatory amino acid (EAA). The receptors that respond to glutamate are called excitatory amino acid receptors (EAA receptors). See Watkins & Evans, Ann. Rev. Pharmacol. Toxicol., 21 , 165 (1981 ); Monaghan, Bridges, and Cotman, Ann. Rev. Pharmacol. Toxicol., 29, 365 (1989); Watkins, Krogsgaard-Larsen, and Honore, Trans. Pharm. Sci., 11 , 25 (1990). The excitatory amino acids are of great physiological importance, playing a role in a variety of physiological processes, such as long-term potentiation (learning and memory), the development of synaptic plasticity, motor control, respiration, cardiovascular regulation, and sensory perception. Excitatory amino acid receptors are classified into two general types. Receptors that are directly coupled to the opening of cation channels in the cell membrane of the neurons are termed "ionotropic". This type of receptor has been subdivided into at least three subtypes, which are defined by the depolarizing actions of the selective agonists /V-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), and kainic acid (KA). The second general type of receptor is the G-protein or second messenger-linked "metabotropic" excitatory amino acid receptor. This second type is coupled to multiple second messenger systems that lead to enhanced phosphoinositide hydrolysis, activation of phospholipase D, increases or decreases in c-AMP formation, and changes in ion channel function. Schoepp and Conn, Trends in Pharmacol. Sci., 14, 13 (1993). Both types of receptors appear not only to mediate normal synaptic transmission along excitatory pathways, but also participate in the modification of synaptic connections during development and throughout life. Schoepp, Bockaert, and Sladeczek, Trends in Pharmacol. Sci., 11 , 508 (1990); McDonald and Johnson, Brain Research Reviews, 15, 41 (1990). AMPA receptors are assembled from four protein sub-units known as GluR1 to GluR4, while kainic acid receptors are assembled from the sub-units GluR5 to GluR7, and KA-1 and KA-2. Wong and Mayer, Molecular Pharmacology 44: 505-510, 1993. It is not yet known how these sub-units are combined in the natural state. However, the structures of certain human variants of each sub-unit have been elucidated, and cell lines expressing individual sub- unit variants have been cloned and incorporated into test systems designed to identify compounds which bind to or interact with them, and hence which may modulate their function. Thus, European patent application, publication number EP-A2-0574257 discloses the human sub-unit variants GluRI B, GluR2B, GluR3A and GluR3B. European patent application, publication number EP-A1- 0583917 discloses the human sub-unit variant GluR4B. One distinctive property of AMPA and kainic acid receptors is their rapid deactivation and desensitization to glutamate. Yamada and Tang, The Journal of Neuroscience, September 1993, 13(9): 3904-3915 and Kathryn M. Partin, J. Neuroscience, November 1 , 1996, 16(21 ): 6634-6647. The physiological implications of rapid desensitization, and deactivation if any, are unknown. It is known that the rapid desensitization and deactivation of AMPA and/or kainic acid receptors to glutamate may be inhibited using certain compounds. This action of these compounds is often referred to in the alternative as "potentiation" of the receptors. One such compound, which selectively potentiates AMPA receptor function, is cyclothiazide. Partin et al., Neuron. Vol. 11 , 1069-1082, 1993. Compounds which potentiate AMPA receptors, like cyclothiazide, are often referred to as ampakines. Intemational Patent Application Publication Number WO 9625926 discloses a group of phenylthioalkylsulphonamides, S-oxides and homologs which are said to potentiate membrane currents induced by kainic acid and AMPA. Ampakines have been shown to improve memory in a variety of animal tests. Staubli er a/., Proc. Natl. Acad. Sci., Vol. 91 , pp 777-781 , 1994, Neurobiology, and Arai et al., The Journal of Pharmacology and Experimental Therapeutics, 278: 627-638, 1996. It has now been found that cyclothiazide and certain sulfonamide derivatives potentiate agonist-induced excitability of human GluR4B receptor expressed in HEK 293 cells. Since cyclothiazide is known to potentiate glutamate receptor function in vivo, it is believed that this finding portends that the sulfonamide derivatives will also potentiate glutamate receptor function in vivo, and hence that the compounds will exhibit ampakine-like behavior. The present invention provides compounds of formula I: R 8 R 6 R 2a 1 1 / R 1 — C-C-SO 9 -N formula I ' 5 ' 7 2b R 5 R 7 R 2b wherein Rl represents a naphthyl group or a phenyl, furyl, thienyl or pyridyl group which is unsubstituted or substituted by one or two substituents selected independently from halogen; nitro; cyano; hydroxyimino; (1 -10C)alkyl; (2-10C)alkenyl; (2- 10C)alkynyl; (3-8C)cycloalkyl; hydroxy(3-8C)cycloalkyi; oxo(3-8C)cycloalkyl; halo(1-10C)alkyl; (CH2)yX 1 R 9 in which y is 0 or an integer of from 1 to 4, X 1 represents O, S, NR 10 , CO, COO, OCO, CONR 1 , NR 12 CO, NR 2 COCOO or OCONR 13 , R 9 represents hydrogen, (1-10C)alkyl, (3-10C)alkenyl, (3- 10C)alkynyl, pyrrolidinyl, tetrahydrofuryl, morpholino or (3-8C)cycloalkyl and R10, R1 1 , R12 and R 1 3 each independently represents hydrogen or (1 - 10C)alkyl, or R 9 and R 10 . R 1 . R 2 or R 13 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group; N-(1 -4C)alkylpiperazinyl; N-phenyl(1 -4C)alkylpiperazinyl; thienyl; furyl; oxazolyl; isoxazolyl; pyrazolyl; imidazolyl; thiazolyl; pyridyl; pyridazinyl; pyrimidinyl; dihydro-thienyl; dihydrofuryl; dihydrothiopyranyl; dihydropyranyl; dihydrothiazolyl; (1-4C)alkoxycarbonyldihydrothiazolyl; (1- 4C)alkoxycarbonyldimethyldihydrothiazolyl; tetrahydro-thienyl; tetrahydrofuryl; tetrahydrothiopyranyl; tetrahydropyranyl; indolyl; benzofuryl; benzothienyl; benzimidazolyl; and a group of formula R 1 4-(|_a) n -χ2_(|_b) m j n which X 2 represents a bond, O, NH, S, SO, SO2, CO, CH(OH), CONH, NHCO, NHCONH, NHCOO, COCONH, OCH2CONH or CH=CH, l_ a and L b each represent (1- 4C)alkylene, one of n and m is 0 or 1 and the other is 0, and R 14 represents a phenyl or heteroaromatic group which is unsubstituted or substituted by one or two of halogen, nitro, cyano, hydroxyimino, (1 -10C) alkyl, (2-10C)alkenyl, (2- 10C)alkynyl, (3-8C)-cycloalkyl, 4-(1 ,1-dioxotetrahydro-1 ,2-thiazinyl), halo(1- 10C)alkyl, cyano(2-10C)alkenyl, phenyl, and (CH2)zX 3 R 1 5 in which z is 0 or an integer of from 1 to 4, X 3 represents O, S, NR^ 6 , CO, CH(OH), COO, OCO, CONR 17 , NR 1 8 CO, NHSO2, NHSO2NR 17 , NHCONH, OCONR 19 or NR 19 COO, R 1 5 represents hydrogen, (1-10C)alkyl, phenyl(1-4C)alkyl, halo(1- 10C)alkyl, (1 -4C)alkoxycarbonyl(1 -4C)alkyl, (1 -4C)alkylsulfonylamino(1 -4C)alkyl, (N-(1 -4C)alkoxycarbonyl)(1 -4C)alkylsulfonylamino-(1 -4C)alkyl, (3-10C)alkenyl, (3-10C)alkynyl, (3-8C)-cycloalkyl, camphoryl or an aromatic or heteroaromatic group which is unsubstituted or substituted by one or two of halogen, (1-4C)alkyl, (1-4C)haloalkyl, di(1-4C)alkylamino and (1-4C)alkoxy and R 16 , R 7 , R18 and R "19 each independently represents hydrogen or (1-10C)alkyl, or R 1 5 and R 16 , R17_ R18 or R19 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group; R 2a and R 2b each independently represent hydrogen, (1 -6C)alkyl, (3- 6C)cycloalkyl, fluoro(1-6C)alkyl, chloro(1 -6C)alkyl, (2-6C)alkenyl, (1- 4C)alkoxy(1-4C)alkyl, (1-6C)alkylN(1-4C)alkyl 2 , (1 -6C)alkylO(1-6C)alkyl, -CH 2 furyl, (3-6C)cycloalkyl(1 -6C)alkyl, (phenyl) 2 (1-6C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy or (3- 6C)cycloalkyl, phenyl(1-6C)alkyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy, or (3-6C)cycloalkyl, naphthyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy or (3- 6C)cycloalkyl, naphthyl(1 -6C)alkyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy or (3-6C)cycloalkyl, or R 2a and R 2b together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and either one of R5 R6, R? and R 8 represents hydrogen, (1-6C)alkyl; aryl(1- 6C)alkyl; (2-6C)alkenyl; aryl(2-6C)alkenyl or aryl, or two of R 5 , R 6 , R 7 and R 8 together with the carbon atom or carbon atoms to which they are attached form a (3-8C) carbocyclic ring; and the remainder of R 5 , R 6 , R 7 and R 8 represent hydrogen; or a pharmaceutically acceptable salt thereof. The present invention further provides a method of potentiating glutamate receptor function in a mammal requiring such treatment, which comprises administering an effective amount of a compound of formula I. According to another aspect, the present invention provides the use of a compound of formula I, or a pharmaceutically acceptable salt thereof as defined hereinabove for the manufacture of a medicament for potentiating glutamate receptor function. In addition, the present invention provides the use of a compound of formula I or a pharmaceutically acceptable salt thereof for potentiating glutamate receptor function. The invention further provides a method of potentiating glutamate receptor function in a mammal requiring such treatment, which comprises administering an effective amount of a compound of formula: wherein R 1 represents an unsubstituted or substituted aromatic or heteroaromatic group; R 2a and R 2b each independently represent hydrogen, (1-6C)alkyl, (3- 6C)cycloalkyl, fluoro(1-6C)alkyl, chloro(1 -6C)alkyl, (2-6C)alkenyl, (1- 4C)alkoxy(1 -4C)alkyl, (1 -6C)alkylN(1 -4C)alkyl 2 , (1 -6C)alkylO(1 -6C)alkyl, -CH 2 furyl, (3-6C)cycloalkyl(1 -6C)alkyl, (phenyl) 2 (1-6C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy or (3- 6C)cycloalkyl, phenyl(1 -6C)alkyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy, or (3-6C)cycloalkyl, naphthyl which is unsubstituted or substituted by halogen, (1 -4C)alkyl, (1-4C)alkoxy or (3- 6C)cycloalkyl, naphthyl(1-6C)alkyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1 -4C)alkoxy or (3-6C)cycloalkyl, , or R 2a and R 2b together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and either one of R5 R6, R 7 and R 8 represents hydrogen, (1-6C)alkyl; aryl(1- 6C)alkyl; (2-6C)alkenyl; aryl(2-6C)alkenyl or aryl, or two of R 5 , R 6 , R 7 and R 8 together with the carbon atom or carbon atoms to which they are attached form a (3-8C) carbocyclic ring; and the remainder of R5 R 6 , R 7 and R 8 represent hydrogen; or a pharmaceutically acceptable salt thereof. In this specification, the term "potentiating glutamate receptor function" refers to any increased responsiveness of glutamate receptors, for example AMPA receptors, to glutamate or an agonist, and includes but is not limited to inhibition of rapid desensitization or deactivation of AMPA receptors to glutamate. A wide variety of conditions may be treated or prevented by the compounds of formula I and their pharmaceutically acceptable salts through their action as potentiators of glutamate receptor function. Such conditions include those associated with glutamate hypofunction, such as psychiatric and neurological disorders, for example cognitive disorders; neuro-degenerative disorders such as Alzheimer's disease; age-related dementias; age-induced memory impairment; movement disorders such as tardive dyskinesia, Hungtington's chorea, myoclonus and Parkinson's disease; reversal of drug- induced states (such as cocaine, amphetamines, alcohol-induced states); depression; attention deficit disorder; attention deficit hyperactivity disorder; psychosis; cognitive deficits associated with psychosis; and drug-induced psychosis. The compounds of formula I may also be useful for improving memory (both short term and long term) and learning ability. The present invention provides the use of compounds of formula I for the treatment of each of these conditions. The term "treating" (or "treat") as used herein includes its generally accepted meaning which encompasses prohibiting, preventing, restraining, and slowing, stopping, or reversing progression, severity, or a resultant symptom. The present invention includes the pharmaceutically acceptable salts of the compounds defined by formula I. A compound of this invention can possess a sufficiently acidic, a sufficiently basic, or both functional groups, and accordingly react with any of a number of organic and inorganic bases, and inorganic and organic acids, to form a pharmaceutically acceptable salt. The term "pharmaceutically acceptable salt" as used herein, refers to salts of the compounds of the above formula which are substantially non-toxic to living organisms. Typical pharmaceutically acceptable salts include those salts prepared by reaction of the compounds of the present invention with a pharmaceutically acceptable mineral or organic acid or an organic or inorganic base. Such salts are known as acid addition and base addition salts. Acids commonly employed to form acid addition salts are inorganic acids such as hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, phosphoric acid, and the like, and organic acids such as p-toluenesulfonic, methanesulfonic acid, oxalic acid, p-bromophenylsulfonic acid, carbonic acid, succinic acid, citric acid, benzoic acid, acetic acid, and the like. Examples of such pharmaceutically acceptable salts are the sulfate, pyrosulfate, bisulfate, sulfite, bisulfite, phosphate, monohydrogenphosphate, dihydrogenphosphate, metaphosphate, pyrophosphate, bromide, iodide, acetate, propionate, decanoate, caprylate, acrylate, formate, hydrochloride, dihydrochloride, isobutyrate, caproate, heptanoate, propiolate, oxalate, malonate, succinate, suberate, sebacate, fumarate, maleate, butyne-1 ,4-dioate, hexyne-1 ,6-dioate, benzoate, chlorobenzoate, methylbenzoate, hydroxybenzoate, methoxybenzoate, phthalate, xylenesulfonate, phenylacetate, phenylpropionate, phenylbutyrate, citrate, lactate, g-hydroxybutyrate, glycolate, tartrate, methanesulfonate, propanesulfonate, naphthalene-1-sulfonate, napththalene-2- sulfonate, mandelate and the like. Preferred pharmaceutically acceptable acid addition salts are those formed with mineral acids such as hydrochloric acid and hydrobromic acid, and those formed with organic acids such as maleic acid and methanesulfonic acid. Base addition salts include those derived from inorganic bases, such as ammonium or alkali or alkaline earth metal hydroxides, carbonates, bicarbonates, and the like. Such bases useful in preparing the salts of this invention thus include sodium hydroxide, potassium hydroxide, ammonium hydroxide, potassium carbonate, sodium carbonate, sodium bicarbonate, potassium bicarbonate, calcium hydroxide, calcium carbonate, and the like. The potassium and sodium salt forms are particularly preferred. It should be recognized that the particular counterion forming a part of any salt of this invention is usually not of a critical nature, so long as the salt as a whole is pharmacologically acceptable and as long as the counterion does not contribute undesired qualities to the salt as a whole. It is further understood that the above salts may form hydrates or exist in a substantially anhydrous form. As used herein, the term "stereoisomer" refers to a compound made up of the same atoms bonded by the same bonds but having different three- dimensional structures which are not interchangeable. The three-dimensional structures are called configurations. As used herein, the term "enantiomer" refers to two stereoisomers whose molecules are nonsuperimposable mirror images of one another. The term "chiral center" refers to a carbon atom to which four different groups are attached. As used herein, the term "diastereomers" refers to stereoisomers which are not enantiomers. In addition, two diastereomers which have a different configuration at only one chiral center are referred to herein as "epimers". The terms "racemate", "racemic mixture" or "racemic modification" refer to a mixture of equal parts of enantiomers. The term "enantiome c enrichment" as used herein refers to the increase in the amount of one enantiomer as compared to the other. A convenient method of expressing the enantiomeric enrichment achieved is the concept of enantiomeric excess, or "ee", which is found using the following equation: ee = E 1 - E 2 X 100 E T E 2 wherein E 1 is the amount of the first enantiomer and E 2 is the amount of the second enantiomer. Thus, if the initial ratio of the two enantiomers is 50:50, such as is present in a racemic mixture, and an enantiomeric enrichment sufficient to produce a final ratio of 50:30 is achieved, the ee with respect to the first enantiomer is 25%. However, if the final ratio is 90:10, the ee with respect to the first enantiomer is 80%. An ee of greater than 90% is preferred, an ee of greater than 95% is most preferred and an ee of greater than 99% is most especially preferred. Enantiomeric enrichment is readily determined by one of ordinary skill in the art using standard techniques and procedures, such as gas or high performance liquid chromatography with a chiral column. Choice of the appropriate chiral column, eluent and conditions necessary to effect separation of the enantiomeric pair is well within the knowledge of one of ordinary skill in the art. In addition, the enantiomers of compounds of formula I can be resolved by one of ordinary skill in the art using standard techniques well known in the art, such as those described by J. Jacques, et al., "Enantiomers, Racemates, and Resolutions", John Wiley and Sons, Inc., 1981. Examples of resolutions include recrystallization techniques or chiral chromatography. Some of the compounds of the present invention have one or more chiral centers and may exist in a variety of stereoisome c configurations. As a consequence of these chiral centers, the compounds of the present invention occur as racemates, mixtures of enantiomers and as individual enantiomers, as well as diastereomers and mixtures of diastereomers. All such racemates, enantiomers, and diastereomers are within the scope of the present invention. The terms "R" and "S" are used herein as commonly used in organic chemistry to denote specific configuration of a chiral center. The term "R" (rectus) refers to that configuration of a chiral center with a clockwise relationship of group priorities (highest to second lowest) when viewed along the bond toward the lowest priority group. The term "S" (sinister) refers to that configuration of a chiral center with a counterclockwise relationship of group priorities (highest to second lowest) when viewed along the bond toward the lowest priority group. The priority of groups is based upon their atomic number (in order of decreasing atomic number). A partial list of priorities and a discussion of stereochemistry is contained in "Nomenclature of Organic Compounds: Principles and Practice", (J.H. Fletcher, et al., eds., 1974) at pages 103-120. As used herein, the term "aromatic group" means the same as aryl, and includes phenyl and a polycyclic aromatic carbocyclic ring such as naphthyl. The term "heteroaromatic group" includes an aromatic 5-6 membered ring containing from one to four heteroatoms selected from oxygen, sulfur and nitrogen, and a bicyclic group consisting of a 5-6 membered ring containing from one to four heteroatoms selected from oxygen, sulfur and nitrogen fused with a benzene ring or another 5-6 membered ring containing one to four atoms selected from oxygen, sulfur and nitrogen. Examples of heteroaromatic groups are thienyl, furyl, oxazolyl, isoxazolyl, oxadiazoyl, pyrazolyl, thiazolyl, thiadiazolyl, isothiazolyl, imidazolyl, triazolyl, tetrazolyl, pyridyl, py dazinyl, pyrimidyl, benzofuryl, benzothienyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, indolyl and quinolyl. The term "substituted" as used in the term "substituted aromatic or heteroaromatic group" herein signifies that one or more (for example one or two) substituents may be present, said substituents being selected from atoms and groups which, when present in the compound of formula I, do not prevent the compound of formula I from functioning as a potentiator of glutamate receptor function. Examples of substituents which may be present in a substituted aromatic or heteroaromatic group include halogen; nitro; cyano; hydroxyimino; (1-1 OC) alkyl; (2-10C)alkenyl; (2-10C)alkynyl; (3-8C)cycloalkyl; hydroxy(3-8C)cycloalkyl; oxo(3-8C)cycloalkyl; halo(1-10C)alkyl; (CH2)yX R 9 in which y is 0 or an integer of from 1 to 4, X 1 represents O, S, NR 1 0 , CO, COO, OCO, CONR 1 , NR 12 CO, NR 12 COCOO, OCONR 1 3 , R 9 represents hydrogen, (1-1 OC) alkyl, (3- 10C)alkenyl, (3-10C)alkynyl, pyrrolidinyl, tetrahydrofuryl, morpholino or (3- 8C)cycloalkyl and R1°> Rl 1 > R^ 2 and R^ 3 each independently represents hydrogen or (1 -10C)alkyl, or R 9 and R °. R 1 1 > R 12 or R 13 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group; N-(1-4C)alkylpiperazinyl; N-phenyl(1- 4C)alkylpiperazinyl; thienyl; furyl; oxazolyl; isoxazolyl; pyrazolyl; imidazolyl; thiazolyl; pyridyl; pyridazinyl; py midinyl; dihydrothienyl; dihydrofuryl; dihydrothiopyranyl; dihydropyranyl; dihydrothiazolyl; (1-4C)alkoxycarbonyl dihydrothiazolyl; (1 -4C)alkoxycarbonyl dimethyl-dihydrothiazolyl; tetrahydrothienyl; tetrahydrofuryl; tetrahydrothiopyranyl; tetrahydropyranyl; indolyl; benzofuryl; benzothienyl; benzimidazolyl; and a group of formula R1 - (l_ a )n-X 2 -(L b )m in which X 2 represents a bond, O, NH, S, SO, SO2, CO, CH(OH), CONH, NHCO, NHCONH, NHCOO, COCONH, OCH2CONH, or CH=CH, l_ a and L D each represent (1-4C)alkylene, one of n and m is 0 or 1 and the other is 0, and R14 represents a phenyl or heteroaromatic group which is unsubstituted or substituted by one or two of halogen; nitro; cyano; (1-10C) alkyl; (2-10C)alkenyl; (2-10C)alkynyl; (3-8C)cycloalkyl; 4-(1 ,1-dioxotetrahydro-1 ,2- thiazinyl); halo(1-10C)alkyl; cyano(2-10C)alkenyl; phenyl; and (CH2) Z X 3 R 15 in which z is 0 or an integer of from 1 to 4, X 3 represents O, S, NR 16 , CO, CH(OH), COO, OCO, CONR 17 , NR 18 CO, NHSO2, NHSO2NR 17 , OCONR 19 or NR 1 9 COO, R 15 represents hydrogen, (1-10C)alkyl, phenyl(1 -4C)alkyl, halo(1 - 10C)alkyl, (1 -4C)alkoxycarbonyl(1 -4C)alkyl, (1 -4C)alkylsulfonylamino(1 -4C)alkyl, N-(1 -4C)alkoxycarbonyl)(1 -4C)alkylsulfonylamino(1 -4C)alkyl, (3-10C)alkenyl, (3- 10C)alkynyl, (3-8C)cycloalkyl, camphoryl, or an aromatic or heteroaromatic group which is unsubstituted or substituted by one or two of halogen, (1-4C)alkyl, halo(1-4C)alkyl, di(1-4C)alkylamino and (1-4C)alkoxy, and R 6 , R 17 , R 8 and R 19 each independently represents hydrogen or (1-10C)alkyl, or R15 and R 16 , R17 | R18 or R "19 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group. The term (1 -10C)alkyl includes (1 -8C)alkyl, (1 -6C)alkyl and (1-4C)alkyl. Particular values are methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, pentyl, hexyl, heptyl, octyl, nonyl and decyl. The term (2-10C)alkenyl includes (3-10C)alkenyl, (1-8C)alkenyl, (1- 6C)alkenyl and (1-4C)alkenyl. Particular values are vinyl and prop-2-enyl. The term (2-10C)alkynyl includes (3-10C)alkynyl, (1 -8C)alkynyl, (1- 6C)alkynyl and (3-4C)alkynyl. A particular value is prop-2-ynyl. The term (3-8C)cycloalkyl, as such or in the term (3-8C)cycloalkyloxy, includes monocyclic and polycyclic groups. Particular values are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and bicyclo[2.2.2]octane. The term includes (3-6C)cycloalkyl: cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. The term hydroxy(3-8C)cycloalkyl includes hydroxy-cyclopentyl, such as 3-hydroxycyclopentyl. The term oxo(3-8C)cycloalkyl includes oxocyclopentyl, such as 3- oxocyclopentyl. The term halogen includes fluorine, chlorine, bromine and iodine. The term halo(1-10C)alkyl includes fluoro(1-10C)alkyl, such as trifluoromethyl and 2,2,2-trifluoroethyl, and chloro(1 -10C)alkyl such as chloromethyl. The term cyano(2-10C)alkenyl includes 2-cyanoethenyl. The term (2-4C)alkylene includes ethylene, propylene and butylene. A preferred value is ethylene. The term thienyl includes thien-2-yl and thien-3-yl. The term furyl includes fur-2-yl and fur-3-yl. The term oxazolyl includes oxazol-2-yl, oxazol-4-yl and oxazol-5-yl. The term isoxazolyl includes isoxazol-3-yl, isoxazol-4-yl and isoxazol-5-yl. The term oxadiazolyl includes [1 ,2,4]oxadiazol-3-yl and [1 ,2,4]oxadiazol- 5-yl. The term pyrazolyl includes pyrazol-3-yl, pyrazol-4-yl and pyrazol-5-yl. The term thiazolyl includes thiazol-2-yl, thiazol-4-yl and thiazol-5-yl. The term thiadiazolyl includes [1 ,2,4]thiadiazol-3-yl, and [1 ,2,4]thiadiazol- 5-yl. The term isothiazolyl includes isothiazol-3-yl, isothiazol-4-yl and isothiazol-5-yl. The term imidazolyl includes imidazol-2-yl, imidazolyl-4-yl and imidazolyl- 5-yl. The term triazolyl includes [1 ,2,4]triazol-3-yl and [1 ,2,4]triazol-5-yl. The term tetrazolyl includes tetrazol-5-yl. The term pyridyl includes pyrid-2-yl, pyrid-3-yl and pyrid-4-yl. The term pyridazinyl includes pyridazin-3-yl, pyridazin-4-yl, pyridazin-5-yl and pyridazin-6-yl. The term pyrimidyl includes pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl and pyhmidin-6-yl. The term benzofuryl includes benzofur-2-yl and benzofur-3-yl. The term benzothienyl includes benzothien-2-yl and benzothien-3-yl. The term benzimidazolyl includes benzimidazol-2-yl. The term benzoxazolyl includes benzoxazol-2-yl. The term benzothiazolyl includes benzothiazol-2-yl. The term indolyl includes indol-2-yl and indol-3-yl. The term quinolyl includes quinol-2-yl. The term dihydrothiazolyl includes 4,5-dihydrothiazol-2-yl, and the term (1 -4C)alkoxycarbonyldihydrothiazolyl includes 4-methoxycarbony 1-4,5- dihydrothiazol-2-yl. The term "-CH 2 furyl" includes the following: The term "(1-6C)alkyl O(1-6C)alkyl" includes the following: The term "(3-6C)cycloalkyl(1-6C)alkyl" includes the following: The term "(phenyl) 2 (1-6C)alkyl" includes the following: The term "phenyl(1-6C)alkyl" includes the following: Examples of phenyl(1-6C)alkyl which is substituted by halogen, (1- 4C)alkyl or (1-4C)alkoxy include the following: Preferably either one or two of R5 R6, R7 and R 8 represents (1-6C)alkyl, aryl(1-6C)alkyl, (2-6C)alkenyl, aryl(2-6C)alkenyl or aryl, or two of R 5 , R 6 , R 7 and R 8 together with the carbon atom or carbon atoms to which they are attached form a (3-8C)carbocyclic ring; and the remainder of R^, R 6 , R 7 and R 8 represent hydrogen. Examples of a (1-6C)alkyl group represented by R 5 , R 6 , R 7 and R 8 are methyl, ethyl and propyl. An example of an aryl(1-C)alkyl group is benzyl. An example of a (2-6C)alkenyl group is prop-2-enyl. An example of a (3- 8C)carbocyclic ring is a cyclopropyl ring. More preferably R^ and R 7 represent hydrogen. Preferably R 5 and R 8 each independently represents hydrogen or (1- 4C)alkyl, or together with the carbon atom to which they are attached form a (3- 8C) carbocyclic ring. More preferably R 8 represents methyl or ethyl, or R 5 and R 8 together with the carbon atom to which they are attached form a cyclopropyl ring. When R 8 represents methyl or ethyl, R 5 preferably represents hydrogen or methyl. Especially preferred are compounds in which R 8 represents methyl and R 5 , R 6 and R 7 represent hydrogen. Preferably R 3 and R 4 each represent methyl. Examples of values for R 2a and R 2D are hydrogen, methyl, ethyl, propyl, 2-propyl, butyl, t-butyl, 2-methylpropyl, cyclohexyl, trifluoromethyl, 2,2,2- trifluoroethyl, chloromethyl, ethenyl, prop-2-enyl, methoxyethyl, phenyl, 4- fluorophenyl, Preferably R 2a and R 2b are hydrogen, ethyl, or 2-propyl. Examples of values for R 9 are hydrogen, methyl, ethyl, propyl, isopropyl, t-butyl, ethenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, 2-pyrrolidinyl, morpholino or 2-tetrahydrofuryl. Examples of values for R 15 are hydrogen, methyl, ethyl, propyl, isopropyl, butyl, t-butyl, benzyl, 2,2,2-trifluoroethyl, 2-methoxycarbonylethyl, cyclohexyl, 10- camphoryl, phenyl, 2-fluorophenyl, 3-fluorophenyl, 2-thfluoromethylphenyl, 4- t fluoromethylphenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 1- (5-dimethylamino)naphthyl, and 2-thienyl. X 1 preferably represents O, CO, CONH or NHCO. z is preferably 0. R 9 is preferably (1 -4C)alkyl, (2-4C)alkenyl, (3-6C)cycloalkyl, pyrrolidinyl, morpholino or tetrahydrofuryl. Particular values for the groups (CH2)yX 1 R 9 and (CH2)zX 3 R 15 include (1-10C)alkoxy, including (1-6C)alkoxy and (1-4C)alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy and isobutoxy; (3-10C)alkenyloxy, including (3- 6C)alkenyloxy, such as prop-2-enyloxy; (3-10C)alkynyloxy, including (3- 6C)alkynyloxy, such as prop-2-ynyloxy; and (1-6C)alkanoyl, such as formyl and ethanoyl. Examples of particular values for y are 0 and 1. Examples of particular values for z are 0, 1 , 2 and 3. I_ a and L preferably each independently represents CH2- X 2 preferably represents a bond, O, NH, CO, CH(OH), CONH, NHCO, NHCONH or OCH2CONH. Preferably the group (CH2)yX 1 R 9 represents CHO; COCH3, OCH3; OCH(CH3)2; NHCOR 9 in which R 9 represents methyl, ethyl, isopropyl, t-butyl, ethenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, 2-pyrolidinyl or morpholino; CONHR 9 in which R 9 represents cyclopropyl or cyclopentyl; NHCOCOOCH3; or 2-tetrahydrofurylmethoxy. Preferably the group (CH2)zX 3 R 1 5 represents NH2; CH2NH2; (CH2)2NH2; (CH2)3NH2; CONH2; CONHCH3; CON(CH3)2; N(C2Hδ)2; CH2OH; CH(OH)CH3; CH(OH)CH2CH2; CHO; COCH3; COOH; COOCH3; CH2NHCOOC(CH3)3; (CH2)2NHCOOC(CH3)3; NHSO2CH(CH3)2; a group of formula (CH2)2NHSO2R 15 in which R 15 represents CH3, CH2CH3, CH(CH3)2, (CH2)2CH3, (CH3)3CH3, benzyl, CH2CF3, 2-methoxycarbonylethyl, cyclohexyl, 10-camphoryl, phenyl, 2-fluorophenyl, 4-fluorophenyl, 2-trifluoromethylphenyl, 4- trifluoromethylphenyl, 4-methoxyphenyl, 1 -(2-dimethylamino)naphthyl or 2- thienyl; CH(OH)CH2NHSO2CH3; (CH2)3NHSO2CH(CH3)2; COCH2N(OCOC(CH3)2SO2CH3; COCH2NHSO2CH3; (CH2)2NHCOR 15 in which R 1 5 represents CH3, CH(CH3)2, CH2CH(CH3)2, phenyl, 3-fluorophenyl, 4-fluorophenyl, benzyl, 2-methoxyphenyl, 4-methoxyphenyl, 2-thienyl, CH=CH, CH=CHCN, OCH3 or O(CH2)3CH3- Examples of particular values for (L a )n-X 2 -(L b )m are a bond, O, NH, S, SO, SO2, CO, CH2, COCH2, COCONH, CH(OH)CH2, CONH, NHCO, NHCONH, CH2O, OCH2, OCH2CONH, CH2NH, NHCH2 and CH2CH2. R^ 4 is preferably an unsubstituted or substituted phenyl, naphthyl, furyl, thienyl, isoxazolyl, thiazolyl, tetrazolyl, pyridyl, pyrimidyl benzothienyl or benzothiazolyl group. Examples of particular values for R^ 4 are phenyl, 2-fluorophenyl, 3- fluorophenyl, 4-fluorophenyl, 2-chloro-phenyl, 3-chlorophenyl, 4-chlorophenyl, 2- bromophenyl, 3-bromophenyl, 4-bromophenyl, 4-iodophenyl, 2,3-difluoro-phenyl, 2,4-difluorophenyl, 3,4-dichlorophenyl, 3,5-dichlorophenyl, 4-cyanophenyl, 3- nitrophenyl, 4-hydroxyiminophenyl, 2-methylphenyl, 4-methylphenyl, 4- ethylphenyl, 3-propylphenyl, 4-t-butylphenyl, 2-prop-2-enylphenyl, 4-(4-(1 ,1- dioxotetrahydro-1 ,2-thiazinyl)phenyl, 2-trifluoromethylphenyl, 3- trifluoromethylphenyl, 4-trifluoromethylphenyl, 2-bromomethylphenyl, 2-fluoro-4- trifluoromethylphenyl, 4-(2-cyanoethenyl)phenyl, 4-phenyl, 2-formylphenyl, 3- formylphenyl, 4-formylphenyl, 2-acetylphenyl, 3-acetylphenyl, 4-acetylphenyl, 2- propanoylphenyl, 2-(2-methyl-propanoyl)phenyl, 2-methoxyphenyl, 3- methoxyphenyl, 4-methoxyphenyl, 4-butoxyphenyl, 2-hydroxymethylphenyl, 4- hydroxymethylphenyl, 2-(1-hydroxyethyl)phenyl, 3-(1-hydroxyethyl)phenyl, 4-(1- hydroxyethyl)phenyl, 2-(1 -hydroxypropyl)phenyl, 4-(1-hydroxypropyl)phenyl, 2- (1 -hydroxy-2,2-dimethyl-propyl)phenyl, 4-trifluoromethoxyphenyl, 2- aminophenyl,4-aminophenyl, 4-N,N-diethylaminophenyl, 4-aminomethylphenyl, 4-(2-aminoethyl)phenyl, 4-(3-aminopropyl)phenyl, 4-carboxyphenyl, 4- carbamoylphenyl, 4-N-methylcarbamoylphenyl, 4-N,N-dimethylcarbamoylphenyl, 2-isopropylaminomethylphenyl, 4-t-butoxycarbonylaminomethylphenyl, 4-(2- isopropoxy-carboxamido)ethylphenyl, 4-(2-t-butoxycarboxamido)ethyl-phenyl, 4- isopropylsulfonylaminophenyl, 4-(2-methane-sulfonylamino)ethylphenyl, 4-(2- ethylsulfonylamino)ethyl-phenyl, 4-(3-isopropylsulfonylamino)propylphenyl, 4-(1 - (2-(2-propane)sulfonylamino)propyl)phenyl, 4-(2-propylsulfonyl- amino)ethylphenyl, 4-(2-isopropylsulfonylamino)ethylphenyl, 4-(2- butylsulfonylamino)ethylphenyl, 4-(1-isopropyl-sulfonylaminomethyl)ethylphenyl, 4-(1 -hydroxy-2-methane-sulfonylamino)ethylphenyl, 4-(2-(2,2,2-trifluoroethyl)- sulfonylaminoethyl)phenyl, 4-(2-cyclohexylsulfonylamino)-ethylphenyl, 4-(2- (2,2,2-trifluoroethyl)sulfonylamino)-ethylphenyl, 4-(2-N,N- dimethylaminosulfonylamino)-ethylphenyl, 4-(2-phenylsulfonylaminoethyl)phenyl, 4-(2-(2-fluorophenyl)sulfonylaminoethyl)phenyl, 4-(2-(4-fluoro- phenyl)sulfonylaminoethyl)phenyl, 4-(2-(2-trifluoromethyl- phenyl)sulfonylaminoethyl)phenyl, 4-(2-(4-trifluoro- methylphenyl)sulfonylaminoethyl)phenyl, 4-(2-(4- methoxyphenyl)sulfonylaminoethyl)phenyl, 4-(2-(1 -(5- dimethylamino)napthalenesulfonylamino)ethyl)phenyl, 4-(2-(2- thienyl)sulfonylamino)ethyl)phenyl, 4-(2-benzamidoethyl)-phenyl, 4-(2-(4- fluorobenzamido)ethyl)phenyl, 4-(2-(3-methoxybenzamido)ethyl)phenyl, 4-(2-(3- fluorobenzamido)-ethyl)phenyl, 4-(2-(4-methoxybenzamido)ethyl)phenyl, 4-(2-(2- methoxybenzamido)ethyl)phenyl, 4-(1 -(2-(2-methoxy- carbonylethanesulfonylamino)ethyl)phenyl, 4-(1 -(2-(10- camphorsulfonylamino)ethyl)phenyl, 4-(1 -(2-(benzylsulfonyl-amino)ethyl)phenyl, 4-(2-phenylacetamido)ethyl)phenyl, 4-methanesulfonylaminoethanoylphenyl, 4- (N-(t-butoxy-carbonyl)methanesulfonylaminoethanoyl)phenyl, 4-(2-(2- thienylcarboxamido)ethyl)phenyl, thien-2-yl, 5-hydroxy-methylthien-2-yl, 5- formylthien-2-yl, thien-3-yl, 5-hydroxymethylthien-3-yl, 5-formylthien-3-yl, 2- bromothien-3-yl, fur-2-yl, 5-nitrofur-2-yl, fur-3-yl, isoxazol-5-yl, 3-bromoisoxazol- 5-yl, isoxazol-3-yl, 5-trimethylsilylisoxazol-3-yl, 5-methylisoxazol-3-yl, 5- hydroxymethylisoxazol-3-yl, 5-methyl-3-phenylisoxazol-4-yl, 5-(2- hydroxyethyl)isoxazol-3-yl, 5-acetylisoxazol-3-yl, 5-carboxyisoxazol-3-yl, 5-N- methylcarbamoylisoxazol-3-yl, 5-methoxycarbonylisoxazol-3-yl, 3- bromo[1 ,2,4]oxadiazol-5-yl, pyrazol-1-yl, thiazol-2-yl, 4-hydroxymethylthiazol-2- yl, 4-methoxycarbonylthiazol-2-yl, 4-carboxythiazol-2-yl, imidazol-1-yl, 2- sulfhydryl-imidazol-1-yl, [1 ,2,4]triazol-1 -yl, tetrazol-5-yl, 2-methyltetrazol-5-yl, 2- ethyltetrazol-5-yl, 2-isopropyl-tetrazol-5-yl, 2-(2-propenyl)tetrazol-5-yl, 2-benzyl- tetrazol-5-yl, pyrid-2-yl, 5-ethoxycarbonylpyrid-2-yl, pyrid-3-yl, 6-chloropyrid-3-yl, pyrid-4-yl, 5-trifluoro-methylpyrid-2-yl, 6-chloropyridazin-3-yl, 6-methylpyridazin- 3-yl, 6-methoxypyrazin-3-yl, pyrimidin-5-yl, benzothien-2-yl, benzothiazol-2-yl, and quinol-2-yl. Examples of an unsubstituted or substituted aromatic or heteroaromatic group represented by R^ are unsubstituted or substituted phenyl, furyl, thienyl (such as 3-thienyl) and pyridyl (such as 3-pyridyl) . More preferably, R^ represents 2-naphthyl or a group of formula in which R 20 represents halogen; nitro; cyano; hydroxyimino; (1 -10C)alkyl; (2- 10C)alkenyl; (2-10C)alkynyl; (3-8C)cyclo-alkyl; hydroxy(3-8C)cycloalkyl; oxo(3- 8C)cycloalkyl; halo(1-10C)alkyl; (CH2)yX 1 R 9 in which y is 0 or an integer of from 1 to 4, X 1 represents O, S, NR 1 °, CO, COO, OCO, CONR 1 1 , NR 12 CO, NR 12 COCOO, OCONR 1 3 , R 9 represents hydrogen, (1 -1 OC) alkyl, (3- 10C)alkenyl, (3-10C)alkynyl, pyrrolidinyl, tetrahydrofuryl, morpholino or (3- 8C)cycloalkyl and R 10 > R 1 1 > R 12 and R 1 3 each independently represents hydrogen or (1 -10C)alkyl, or R 9 and R °> R 1 . R 12 or R 1 3 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group; N-(1-4C)alkylpiperazinyl; N-phenyl(1- 4C)alkylpiperazinyl; thienyl; furyl; oxazolyl; isoxazolyl; pyrazolyl; imidazolyl; thiazolyl; tetrazolyl; pyridyl; pyridazinyl; pyrimidinyl; dihydrothienyl; dihydrofuryl; dihydrothiopyranyl; dihydropyranyl; dihydrothiazolyl; (1-4C)alkoxycarbonyl- dihydrothiazolyl; (1-4C)alkoxycarbonyldimethyl-dihydrothiazolyl; tetrahydrothienyl; tetrahydrofuryl; tetrahydrothiopyranyl; tetrahydropyranyl; indolyl; benzofuryl; benzothienyl; benzimidazolyl; benzothiazolyl; and a group of formula R 14 -(L a ) n -X 2 -( b ) m in which X 2 represents a bond, O, NH, S, SO, SO2, CO, CH(OH), CONH, NHCONH, NHCOO, COCONH, OCH2CONH or CH=CH, NHCO, L a and L b each represent (1-4C)alkylene, one of n and m is 0 or 1 and the other is 0, and R 4 represents a phenyl or hetero-aromatic group which is unsubstituted or substituted by one or two of halogen; nitro; cyano; (1-10C)alkyl; (2-10C)alkenyl; (2-10C)alkynyl; (3-8C)cycloalkyl; 4-(1 ,1-dioxotetrahydro-1 ,2- thiazinyl); halo(1 -10C)alkyl; cyano(2-10C)alkenyl; phenyl; (CH2)zX 3 R 15 in which z is 0 or an integer of from 1 to 4, X 3 represents O, S, NR 16 , CO, CH(OH), COO, OCO, CONR 17 , NR 1 8 CO, NHSO2, NHSO2NR 17 , NHCONH, OCONR 19 or NR 1 9 COO, R 15 represents hydrogen, (1-10C)alkyl, phenyl(1-4C)alkyl, halo(1- 10C)alkyl, (1 -4C)alkoxycarbonyl(1 -4C)alkyl, (1 -4C)alkylsulfonylamino(1 -4C)alkyl, (N-(1 -4C)alkoxycarbonyl)(1 -4C)alkylsulfonylamino(1 -4C)alkyl, (3-1 OC)alkenyl, (3-10C)alkynyl, (3-8C)cycloalkyl, camphoryl or an aromatic or heteroaromatic group which is unsubstituted or substituted by one or two of halogen, (1 -4C)alkyl, halo(1 -4C)alkyl, di(1-4C)alkylamino and (1 -4C)alkoxy, and R 16 , R 7 , R 18 and R 1 9 each independently represents hydrogen or (1-10C)alkyl, or R 1 5 and R 16 , R 17 , R 18 or R 9 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group; and R 2 represents a hydrogen atom, a halogen atom, a (1 -4C)alkyl group or a (1 -4C)alkoxy group. Examples of particular values for R 2n are fluorine, chlorine, bromine, cyano, hydroxyimino, methyl, ethyl, propyl, 2-propyl, butyl, 2-methylpropyl, 1 ,1- dimethylethyl, cyclopentyl, cyclohexyl, 3-hydroxycyclopentyl, 3-oxocyclopentyl, methoxy, ethoxy, propoxy, 2-propoxy, acetyl, acetylamino, ethylcarboxamido, propylcarboxamido, 1 -butanoylamido, t-butylcarboxamido, acryloylamido, 2- pyrrolidinylcarboxamido, 2-tetrahydrofurylmethoxy, morpholinocarboxamido, methyloxalylamido, cyclo-propylcarboxamido, cyclobutylcarboxamido, cyclopentyl-carboxamido, cyclohexylcarboxamido, cyclopropylcarbamoyl, cyclopentylcarbamoyl, pyrrolidin-1-yl, morpholino, piperidin-1-yl, N- methylpiperazinyl, N-benzylpiperazinyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, isoxazol-3-yl, thiazol-2-yl, tetrazol-5-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, pyrimidin- 5-yl, 4,5-dihydrothiazol-2-yl, 4,5-dihydro-4-methoxycarbonylthiazol-2-yl, 4,5- dihydro-4-methoxy-carbonyl-5,5-dimethylthiazol-2-yl, benzothien-2-yl, benzothiazol-2-yl, phenyl, 2-fluorophenyl, 3-fluorophenyl, 2,3-difluorophenyl, 4- chlorophenyl, 3,4-dichlorophenyl, 3,5-dichlorophenyl, 3-nitrophenyl, 4- cyanophenyl, 2-methylphenyl, 4-methylphenyl, 4-(4-(1 ,1-dioxotetrahydro-1 ,2- thiazinyl)phenyl, 3-trifluoromethylphenyl, 4-trifluoro-methylphenyl, 4-(2- cyanoethenyl)phenyl, 2-formylphenyl, 3-formylphenyl, 4-formylphenyl, 3-acetyl- phenyl, 4-acetyl phenyl, 4-carboxyphenyl, 2-methoxyphenyl, 4-methoxyphenyl, 2- hydroxymethylphenyl, 4-hydroxymethylphenyl, 3-(1-hydroxyethyl)phenyl, 4-(1- hydroxyethyl)phenyl, 4-(1-hydroxypropyl)phenyl, 2-aminophenyl, 4-aminophenyl, 4-N,N-diethylaminophenyl, 4-aminomethylphenyl, 4-(2-aminoethyl)-phenyl, 4-(3- aminopropyl)phenyl, 4-(2-acetylaminoethyl)-phenyl, 4-t- butoxycarboxylaminoethyl)phenyl, 4-(2-t-butoxycarboxylaminoethyl)phenyl, benzylsulfonylamino, 4-isopropylsulfonylaminophenyl, 4-(2-methanesulfonyl- aminoethyl)phenyl, 4-(2-ethylsulfonylaminoethyl)phenyl, 4-(2- propylsulfonylaminoethyl)phenyl, 4-(2-butylsulfonyl-aminoethyl)phenyl, 4-(2- isopropylsulfonylaminoethyl)phenyl, 4-(1 -hydroxy-2- methanesulfonylaminoethyl)phenyl, 4-(2- dimethylaminosulfonylaminoethyl)phenyl, 4-(1 -(2-(2- propyl)sulfonylaminopropyl)phenyl, 4-(2-(2,2,2-trifluoro- ethyl)sulfonylaminoethyl)phenyl, 4-(2-cyclohexylsulfonyl-aminoethyl)phenyl, 4-(2- phenylsulfonylaminoethyl)phenyl, 4-(2-(2- fluorophenyl)sulfonylaminoethyl)phenyl, 4-(2-(4- fluorophenyl)sulfonylaminoethyl)phenyl, 4-(2-(2- trifluoromethylphenyl)sulfonylaminoethyl)phenyl, 4-(2-(4- trifluoromethylphenyl)sulfonylaminoethyl)phenyl, 4-(2-(4- methoxyphenyl)sulfonylaminoethyl)phenyl, 4-(2-(1 -(5- dimethylamino)napthalenesulfonylamino)ethyl)phenyl, 4-(2-(2- thienyl)sulfonylamino)ethyl)phenyl, 4-(2-benzamidoethyl)-phenyl, 4-(2-(4- fluorobenzamido)ethyl)phenyl, 4-(2-(3-methoxybenzamido)ethyl)phenyl, 4-(2-(3- fluorobenzamido)-ethyl)phenyl, 4-(2-(4-methoxybenzamido)ethyl)phenyl, 4-(2-(2- methoxybenzamido)ethyl)phenyl, 4-(2-(2-thienyl-carboxamido)ethyl)phenyl, 4- carbamoylphenyl, 4-methyl-carbamoylphenyl, 4-dimethylcarbamoylphenyl, 4-(2- (2-methylpropaneamido)ethyl)phenyl, 4-(2-(3-methyl-butaneamido)ethyl)phenyl, benzoylmethyl, benzamido, 2-fluorobenzamido, 3-flurobenzamido, 4- fluorobenzamido, 2,4-difluorobenzamido, 3-chlorobenzamido, 4- chlorobenzamido, 4-bromobenzamido, 4-iodobenzamido, 4-cyanobenzamido, 3- methylbenzamido, 4-methylbenzamido, 4-ethylbenzamido, 4-propylbenzamido, 4-t-butylbenzamido, 4-vinylbenzamido, 2-trifluoromethylbenzamido, 3- trifluoromethylbenzamido, 4-trifluoromethyibenzamido, 2-fluoro-4-trifluoromethyl- benzamido, 2-methoxybenzamido, 3-methoxybenzamido, 4-methoxybenzamido, 4-butoxybenzamido, 4-phenylphenyl-carboxamido, 4-benzylcarboxamido, 4- phenoxymethyl-carboxamido, 2-fluorobenzylamino, benzyloxy, 2-fluoro- benzyloxy, 2-hydroxy-2-phenylethyl, 2-fluorophenylcarbamoyl, 4-(1-(2-(2- methoxycarbonylethanesulfonylamino)ethyl)phenyl, 4-(1 -(2-(10- camphorsulfonylamino)ethyl)phenyl, 4-(1 -(2-(benzylsulfonylamino)ethyl)phenyl, 4-(2-phenylacetamido)-ethyl)phenyl, 4-(methanesulfonylaminoethanoyl)phenyl, 4-(N-t-butoxycarbonyl)methanesulfonylaminoethanoyl)phenyl, 2- thienylcarboxamido, 2-furylcarboxamido, 3-(5-methyl-isoxazolyl)carboxamido, 5- isoxazolylcarboxamido, 2-benzothienylcarboxamido, 4-(5-methyl-3- phenylisoxazolyl)-carboxamido, 4-pyhdylcarboxamido, 2-(5-nitrofuryl)- carboxamido, 2-pyridylcarboxamido, 6-chloro-2-pyridyl-carboxamido, 2- thienylsulfonamido, 2-thienylmethylamino, 3-thienylmethylamino, 2- furylmethylamino, 3-furylmethylamino, 3-acetylureido and 2-(2- thienyl)ethylureido. Examples of particular values for R 2 are hydrogen and chlorine. R 2 is preferably ortho to R 2u \ Examples of particular values for R 1 are 2-naphthyl, 4-bromophenyl, 4- cyanophenyl, 4-benzamidophenyl, 4-methylphenyl, 4-isopropyl-phenyl, 4- isobutylphenyl, 4-f-butylphenyl, 4-methoxyphenyl, 4-isopropoxyphenyl, 4- cyclopentylphenyl, 4-cyclohexylphenyl, 4-(2-hydroxymethylphenyl)phenyl, 4-(4- hydroxymethylphenyl)-phenyl, 4-(2-furyl)phenyl, 4-(3-furyl)phenyl, 4-(2-thienyl)- phenyl, 4-(3-thienyl)phenyl, 4-(pyrrolidin-1 -yl)phenyl, 4-(piperidin-l-yl)phenyl, 3- chloro-4-piperidin-1 -ylphenyl, 4-benzyloxyphenyl, 4-(2-fluorophenyl)phenyl, 4-(3- fluoro-phenyl)phenyl, 4-(2-formylphenyl)phenyl, 4-(3-formylphenyl)-phenyl, 4-(4- formylphenyl)phenyl, 4-(4-methylphenyl)phenyl and 4-(2-methoxyphenyl)phenyl. The compounds of formula I can be prepared as described in Scheme I below. The reagents and starting materials are readily available to one of ordinary skill in the art. All the substituents, unless otherwise specified are previously defined. Scheme I R 8 R 6 R 2a R 8 R 6 R 2a . I I / R 1 — C-C-SO 2 -Lg + H-N R— C-C-SOz-N R 5 R 7 2b R 2b R R R formula III formula II formula I In Scheme I, the compound of formula II is reacted with the compound of formula III under standard conditions well known in the art, to provide the compound of formula I. More specifically, the compound of formula II is dissolved in a suitable organic solvent. Examples of suitable organic solvents include methylene chloride, tetrahydrofuran, ethyl acetate, acetonitrile, and the like. The solution is treated with a slight excess of a suitable base, and then cooled to about -78°C to about 0°C. Examples of suitable bases include triethylamine, DBU, pyridine, and the like. To the stirring solution is added one equivalent of a compound of formula III. The term "Lg" as used herein refers to a suitable leaving group. Examples of suitable leaving groups include, Cl, Br, F, I, and the like. Cl is the preferred leaving group. The reaction mixture is stirred at about 0°C to about 50°C for about 0.5 hours to about 16 hours. The compound of formula I is then isolated and purified by techniques well known in the art, such as extraction techniques and chromatography. For example, the reaction is treated with a suitable acid, such as dilute hydrochloric acid, to neutralize or make the solution slightly acidic and then extracted with a suitable organic solvent, such as methylene chloride. The organic extracts are combined, dried over anhydrous magnesium sulfate, filtered and concentrated under vacuum to provide the crude material of formula I. The crude material can be purified by flash chromatography on silica gel with a suitable eluent to provide the purified compound of formula I. Examples of suitable eluents are ethyl acetate, hexanes, and the like. Compounds of formula III can be prepared following the procedure described in Scheme II. Unless otherwise indicated, the substituents are previously defined. The reagents and starting materials are readily available to one of ordinary skill in the art. Scheme II formula In Scheme II, step A, the compound of structure (1 ) is treated with an equivalent of thiourea (2) in a suitable organic solvent, such as 95% ethanol. Lg' represents a suitable leaving group. Examples of suitable leaving groups are Br, Cl, F, I, and the like. Br is the preferred leaving group. The reaction mixture is heated at about 80°C for about 60 hours. After cooling, the reaction mixture is concentrated under vacuum and the residue is suspended in a suitable organic solvent, such as diethyl ether. The solid is then collected by filtration and then dissolved in water with heat. To this solution is added a slight excess of potassium acetate to provide the compound (3) which can be collected by filtration and dried under vacuum. In Scheme II, step B, compound (3) is oxidized under standard conditions to provide the compound of formula III. For example, compound (3) is dissolved in water and cooled to about 0°C. To this solution is added a catalytic amount of hydrochloric acid and chlorine gas is bubble through the solution for about 3 to 5 hours. The reaction mixture is then extracted with a suitable organic solvent, such as methylene chloride. The organic extracts are combined, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum to provide the compound of formula III. The compounds of formula la and formula lb can be prepared according Scheme III. Unless otherwise indicated, the substituents are previously defined. The reagents and starting materials are readily available to one of ordinary skill in the art. Scheme III ( 4 ) (5) (6) formula la (δ) Step D Step C formula lb ln Scheme ill, step A, the compound of structure (4) is treated with an amine of structure (5) in a manner analogous to the procedure of described above in Scheme 1 to provide the sulfonamide of structure (6). In Scheme III, step B, the compound of structure (6) is converted to an anion under conditions well known to one of ordinary skill in the art, and then reacted with the compound of structure (7) to provide the alcohol of structure (8). For example, compound (6) is dissolved in a suitable organic solvent, such as tetrahydrofuran and cooled to about -78°C. It is then treated with about two equivalents of a suitable base, such as n-butyllithium. The reaction mixture is allowed to warm to about 0°C, over one to two hours and then cooled back to about -78°C. To this solution is added an excess of a compound (7) and the reaction mixture is allowed to warm to room temperature. It is then quenched with water and the alcohol (8) is isolated and purified by techniques well known in the art, such as extraction techniques and chromatography. For example, the quenched reaction mixture is extracted with a suitable organic solvent, such as diethyl ether, the organic extracts are combined, dried over anhydrous magnesium sulfate, filtered and concentrated under vacuum. The crude product can then be purified for example by flash chromatography on silica gel with a suitable eluent, such as ethyl acetate/hexanes to provide the purified alcohol (8). In Scheme III, step C, the alcohol (8) is reduced under standard conditions well known to one of ordinary skill in the art to provide the compound of formula la. For example, the alcohol (8) is dissolved in a suitable organic solvent, such as methylene chloride and treated with an excess of trifluoroacetic acid. To this mixture is then added an excess of triethylsilane and the reaction is stirred for about 2 to 4 hours at a temperature of about 23°C to reflux. The product is then isolated and purified using standard techniques. For example, the reaction mixture is concentrated under vacuum and the crude residue is purified by flash chromatography on silica gel with a suitable eluent, such as ethyl acetate/hexanes to provide the purified compound of formula la. In Scheme III, step C, the alcohol (8) can be reduced under conditions analogous to those described in Step C to provide the compound of formula lb using only one equivalent of trifluoroacetic acid instead of employing excess trifluoroacetic acid. In Scheme III, step D, the compound of formula la can be alkylated under conditions well known in the art to provide the compound of formula lb. For example, see J. March, "Advanced Organic Chemistry: Reactions, Mechanisms, and Structure," 2 nd Edition, McGraw-Hill, Inc. (1977) pages 377-378. The compounds of formula I in which R represents a 4-bromophenyl group may conveniently be converted into other compounds of formula I in which R represents another 4-substituted phenyl group by reaction with an appropriate boronic acid derivative, for example, a benzeneboronic acid derivative. The reaction is conveniently performed in the presence of a tetrakis (triarylphosphine)palladium(O) catalyst, such as tetrakis (thphenylphosphine)palladium(O) and a base such as potassium carbonate. Convenient solvents for the reaction include aromatic hydrocarbons, such as toluene. The temperature at which the reaction is conducted is conveniently in the range of from 0 to 150°C, preferably 75 to 120°C. Bis aromatic intermediates useful in the preparation of compounds of formula I may be prepared by reacting a bromoaromatic or bromoheteroaromatic compound with an aromatic or heteroaromatic boronic acid in an analogous manner. More specifically, for example, to a degassed solution of a compound of formula I wherein R 1 represents a 4-bromophenyl group, approximately 1.5 equivalents of a benzeneboronic acid derivative, such as 3- fluorobenzeneboronic acid, and approximately 1.5 equivalents of potassium carbonate in a suitable organic solvent, such as toluene, is added a catalytic amount of bis(triphenyl-phosphine)palladium(ll) dichloride. The mixture is heated to about 100°C for about 16 hours, cooled to ambient temperature and diluted with ethyl acetate. The mixture is washed with water and the organic portion is separated. The aqueous portion is extracted with ethyl acetate and the combined organics are dried anhydrous magnesium sulfate, filtered and concentrated under vacuum. Chromatography on silica gel with a suitable eluent, such as ethyl acetate/toluene provides the desired bis aromatic compound of formula I. The boronic acid derivative used as a starting material may be prepared by reacting a trialkyl borate, such as triisopropyl borate with an appropriate organolithium compound at reduced temperature. For example, 2-fluoro- benzeneboronic acid may be prepared by reacting 2-fluorobromobenzene with butyllithium in tetrahydrofuran at about -78°C to afford 2-fluorophenyl lithium, and then reacting this organolithium compound with triisopropyl borate. Alternatively, the compounds of formula I in which R 1 represents a 4- bromophenyl group may be converted to a 4-(thmethylstannyl)phenyl or 4-(tri-n- butylstannyl)phenyl group by treatment of the corresponding bromide with a palladium(O) catalyst, such as tetrakis(thphenylphosphine)-palladium(0) and hexaalkyldistannane, where the alkyl group is methyl or n-butyl, in an aprotic solvent such as toluene in the presence of a tertiary amine base such as triethyl- amine, at temperatures ranging from 80 to 140°C, preferably from 90 to 110°C. The compounds of formula I in which R 1 represents a 4-(tri-n- butylstannyl)phenyl group may then be reacted with an aryl- or heteroarylbromide, such as 2-bromothiophene-5-carboxaldehyde, in the presence of a palladium(O) catalyst, such as tetrakis(triphenylphosphine)palladium(0), or a palladium(ll) catalyst, such as bis(triphenylphosphine)-palladium(ll) dichloride, in an aprotic solvent, such as dioxane, at temperatures ranging from 80 to 140°C, preferably from 90 to 110°C, to afford the corresponding 4-(aryl)phenyl or 4-(heteroaryl)phenyl substituted compound. The compounds of formula I in which R 1 represents a 4-bromophenyl group may be converted into other compounds of formula I in which R 1 represents a 4-substituted alkyl- or cycloalkylphenyl group, such as 4- cyclopentylphenyl by treatment of the corresponding bromide with an appropriate alkyl- or cycloalkyl Grignard reagent, such as cyclopentyl-magnesium bromide, in the presence of a palladium(ll) catalyst, such as [1 ,1'- bis(diphenylphosphino)ferrocene]-dichloropalladium(ll)(PdCI 2 (dppf)), in an aprotic solvent, such as diethyl ether at temperatures ranging from -78°C to 25°C. The compounds of formula I in which R 1 represents a 4-bromophenyl group may be converted into a 4-substituted carboxyaldehydephenyl(formylphenyl) group by reaction of the corresponding bromide with the carbon monoxide gas which is bubbled into the reaction under atmospheric pressure in the presence of a palladium(ll) catalyst, such as bis(triphenyl-phosphine)palladium(ll) dichloride and sodium formate in an aprotic solvent, such as dimethylformamide at temperatures ranging from 70 to 110°C, preferably at 90°C. The compounds of formula I in which R 1 represents a 4-hydroxyphenyl group may be converted into other compounds of formula I in which R 1 represents an alkoxy group by treatment of the corresponding hydroxyphenyl group with an appropriate alkylhalide such as benzylbromide in the presence of sodium hydride in an aprotic solvent such as dimethylformamide at temperatures ranging from 25 to 100°C, preferably from 50 to 90°C. The ability of compounds of formula I to potentiate glutamate receptor- mediated response may be determined using fluorescent calcium indicator dyes (Molecular Probes, Eugene, Oregon, Fluo-3) and by measuring glutamate- evoked efflux of calcium into GluR4 transfected HEK293 cells, as described in more detail below. In one test, 96 well plates containing confluent monolayers of HEK cells stably expressing human GluR4B (obtained as described in European Patent Application Publication Number EP-A1-583917) are prepared. The tissue culture medium in the wells is then discarded, and the wells are each washed once with 200 μl of buffer (glucose, 10mM, sodium chloride, 138mM, magnesium chloride, 1 mM, potassium chloride, 5mM, calcium chloride, 5mM, N-[2- hydroxyethyl]-piperazine-N-[2-ethanesulfonic acid], 10mM, to pH 7.1 to 7.3). The plates are then incubated for 60 minutes in the dark with 20 μM Fluo3-AM dye (obtained from Molecular Probes Inc., Eugene, Oregon) in buffer in each well. After the incubation, each well is washed once with 100 μl buffer, 200 μl of buffer is added and the plates are incubated for 30 minutes. Solutions for use in the test are also prepared as follows. 30 μM, 10 μM, 3 μM and 1 μM dilutions of test compound are prepared using buffer from a 10 mM solution of test compound in DMSO. 100 μM cyclothiazide solution is prepared by adding 3 μl of 100 mM cyclothiazide to 3 ml of buffer. Control buffer solution is prepared by adding 1.5 μl DMSO to 498.5 μl of buffer. Each test is then performed as follows. 200 μl of control buffer in each well is discarded and replaced with 45 μl of control buffer solution. A baseline fluorescent measurement is taken using a FLUOROSKAN II fluorimeter (Obtained from Labsystems, Needham Heights, MA, USA, a Division of Life Sciences International Pic). The buffer is then removed and replaced with 45 μl of buffer and 45 μl of test compound in buffer in appropriate wells. A second fluorescent reading is taken after 5 minutes incubation. 15 μl of 400 μM glutamate solution is then added to each well (final glutamate concentration 100 μM), and a third reading is taken. The activities of test compounds and cyclothiazide solutions are determined by subtracting the second from the third reading (fluorescence due to addition of glutamate in the presence or absence of test compound or cyclothiazide) and are expressed relative to enhance fluorescence produced by 100 μM cyclothiazide. In another test, HEK293 cells stably expressing human GluR4 (obtained as described in European Patent Application Publication No. EP-A1 -0583917) are used in the electro-physiological characterization of AMPA receptor potentiators. The extracellular recording solution contains (in mM): 140 NaCI, 5 KCI, 10 HEPES, 1 MgCI 2 , 2 CaCI 2 , 10 glucose, pH = 7.4 with NaOH, 295 mOsm kg-1. The intracellular recording solution contains (in mM): 140 CsCI, 1 MgCI 2 , 10 HEPES, (N-[2-hydroxyethyl]piperazine-N1-[2-ethanesulfonic acid]) 10 EGTA (ethylene-bis(oxyethylene-nitrilo)tetraacetic acid), pH = 7.2 with CsOH, 295 mOsm kg-1. With these solutions, recording pipettes have a resistance of 2-3 MΩ. Using the whole-cell voltage clamp technique (Hamill et al.(1981 )Pflϋgers Arch., 391 : 85-100), cells are voltage-clamped at -60mV and control current responses to 1 mM glutamate are evoked. Responses to 1 mM glutamate are then determined in the presence of test compound. Compounds are deemed active in this test if, at a test concentration of 10 μM, they produce a greater than 30% increase in the value of the current evoked by 1 mM glutamate. In order to determine the potency of test compounds, the concentration of the test compound, both in the bathing solution and co-applied with glutamate, is increased in half log units until the maximum effect was seen. Data collected in this manner are fit to the Hill equation, yielding an EC 50 value, indicative of the potency of the test compound. Reversibility of test compound activity is determined by assessing control glutamate 1 mM responses. Once the control responses to the glutamate challenge are re-established, the potentiation of these responses by 100 μM cyclothiazide is determined by its inclusion in both the bathing solution and the glutamate-containing solution. In this manner, the efficacy of the test compound relative to that of cyclothiazide can be determined. According to another aspect, the present invention provides a pharmaceutical composition, which comprises a compound of formula I or a pharmaceutically acceptable salt thereof as defined hereinabove and a pharmaceutically acceptable diluent or carrier. The pharmaceutical compositions are prepared by known procedures using well-known and readily available ingredients. In making the compositions of the present invention, the active ingredient will usually be mixed with a carrier, or diluted by a carrier, or enclosed within a carrier, and may be in the form of a capsule, sachet, paper, or other container. When the carrier serves as a diluent, it may be a solid, semi-solid, or liquid material which acts as a vehicle, excipient, or medium for the active ingredient. The compositions can be in the form of tablets, pills, powders, lozenges, sachets, cachets, elixirs, suspensions, emulsions, solutions, syrups, aerosols, ointments containing, for example, up to 10% by weight of active compound, soft and hard gelatin capsules, suppositories, sterile injectable solutions, and sterile packaged powders. Some examples of suitable carriers, excipients, and diluents include lactose, dextrose, sucrose, sorbitol, mannitol, starches, gum, acacia, calcium phosphate, alginates, tragcanth, gelatin, calcium silicate, micro-crystalline cellulose, polyvinylpyrrolidone, cellulose, water syrup, methyl cellulose, methyl and propyl hydroxybenzoates, talc, magnesium stearate, and mineral oil. The formulations can additionally include lubricating agents, wetting agents, emulsifying and suspending agents, preserving agents, sweetening agents, or flavoring agents. Compositions of the invention may be formulated so as to provide quick, sustained, or delayed release of the active ingredient after administration to the patient by employing procedures well known in the art. The compositions are preferably formulated in a unit dosage form, each dosage containing from about 1 mg to about 500 mg, more preferably about 5 mg to about 300 mg (for example 25 mg) of the active ingredient. The term "unit dosage form" refers to a physically discrete unit suitable as unitary dosages for human subjects and other mammals, each unit containing a predetermined quantity of active material calculated to produce the desired therapeutic effect, in association with a suitable pharmaceutical carrier, diluent, or excipient. The following formulation examples are illustrative only and are not intended to limit the scope of the invention in any way. Formulation 1 Hard gelatin capsules are prepared using the following ingredients: The above ingredients are mixed and filled into hard gelatin capsules in 460 mg quantities. Formulation 2 Tablets each containing 60 mg of active ingredient are made as follows: The active ingredient, starch, and cellulose are passed through a No. 45 mesh U.S. sieve and mixed thoroughly. The solution of polyvinylpyrrolidone is mixed with the resultant powders which are then passed through a No. 14 mesh U.S. sieve. The granules so produced are dried at 50°C and passed through a No. 18 mesh U.S. sieve. The sodium carboxymethyl starch, magnesium stearate, and talc, previously passed through a No. 60 mesh U.S. sieve, are then added to the granules which, after mixing, are compressed on a tablet machine to yield tablets each weighing 150 mg. As used herein the term "patient" refers to a mammal, such a mouse, guinea pig, rat, dog or human. It is understood that the preferred patient is a human. As used herein the term "effective amount" refers to the amount or dose of the compound which provides the desired effect in the patient under diagnosis or treatment. The particular dose of compound administered according to this invention will of course be determined by the particular circumstances surrounding the case, including the compound administered, the route of administration, the particular condition being treated, and similar considerations. The compounds can be administered by a variety of routes including oral, rectal, transdermal, subcutaneous, intravenous, intramuscular, or intranasal routes. Alternatively, the compound may be administered by continuous infusion. A typical daily dose will contain from about 0.01 mg/kg to about 100 mg/kg of the active compound of this invention. Preferably, daily doses will be about 0.05 mg/kg to about 50 mg/kg, more preferably from about 0.1 mg/kg to about 25 mg/kg. The following examples represent typical syntheses of compounds within formula I as described generally above. These examples are illustrative only and are not intended to limit the invention in any way. The reagents and starting materials are readily available to one of ordinary skill in the art. As used herein, the following terms have the meanings indicated: "eq" refers to equivalents; "g" refers to grams; "mg" refers to milligrams; "L" refers to liters; "mL" refers to milliliters; "μL" refers to microliters; "mol" refers to moles; "mmol" refers to millimoles; "psi" refers to pounds per square inch; "min" refers to minutes; "h" refers to hours; "°C" refers to degrees Celsius; "TLC" refers to thin layer chromatography; "HPLC" refers to high performance liquid chromatography; "R f " refers to retention factor; "R t " refers to retention time; "δ"refers to part per million down-field from tetramethylsilane; "THF" refers to tetrahydrofuran; "DMF" refers to N,N-dimethylformamide; "DMSO" refers to methyl sulfoxide; "LDA" refers to lithium diisopropylamide; "aq" refers to aqueous; "TFA" refers to trifluoroacetic acid: "iPrOAc" refers to isopropyl acetate; "Me" refers to a methyl group: "Et" refers to an ethyl group: "iPr" refers to an isopropyl group; "Bu" refers to a butyl group; "EtOAc" refers to ethyl acetate; and "RT" refers to room temperature. Example 1 Preparation of N-(2-propyl)-1-(2-phenylpropanesulfonamide). Scheme II, step A: S-2-phenylpropylthiuronium acetate: A solution of 10.0 g (50.2 mmol) of 1-bromo-2-phenylpropane and 3.8 g (50.2 mmol) of thiourea in 30 mL of 95% ethanol was heated to 80°Cfor 60 hours. The reaction mixture was cooled to room temperature and concentrated in vacuo . The residue was suspended in 100 mL of diethyl ether, filtered and air dried. The solid was dissolved in 120 mL of water at 80°C and 20 mL of saturated aqueous potassium acetate was added . After cooling to room temperature, the resulting crystals were filtered and dried concentrated in vacuo to afford 10.2 g (80%) of the title compound. Scheme II, step B: 2-phenylpropanesulfonyl chloride: Through a 0°C suspension of 18.2 g (40.0 mmol) of material from step A in 100 mL of water and 1.1 mL of concentrated hydrochloric acid was bubbled chlorine gas slowly for three hours. The mixture was extracted three times with 50 mL each of dichloromethane. The combined organics were dried (Na 2 SO ), filtered and concentrated in vacuo to afford 6.6 g (75%) of the title compound as a yellow oil. Scheme I: To a 0°C solution of 0.2 g (2.3 mmol) of 2-propylamine and 0.2 g (2.3 mmol) of triethylamine in 10 mL of dichloromethane was added 0.5 g (2.3 mmol) of material from step B and the mixture was stirred for 20 minutes. The mixture was washed once with 10 mL of 10% aqueous sodium bisulfate. The organic portion was separated and the aqueous portion was extracted once with 5 mL of dichloromethane. The combined organic portions were dried (Na2SO4) t filtered and concentrated in vacuo. Chromatography (50 g of silica gel, 25% ethyl acetate/hexanes) of the residue afforded 0.3 g (47%) of the title compound. Electrospray Mass Spectrum: M = 241. Example 2 Preparation of N-t-butyl-2-(4-bromophenyl)-2-hvdroxypropanesulfonamide. Scheme III, step A: N-t-butyl methanesulfonamide: To a 0°C solution of 10 g (136.7 mmol) of t-butylamine and 15.2 g (150.4 mmol) of triethylamine in 350 mL of dichloromethane was added 15.7 g (136.7 mmol) of methanesulfonyl chlo de in 20 mL of dichloromethane over 15 minutes. Continue stirring at 0°C for 30 minutes then warm to room temperature over one hour. The mixture was washed once with 250 mL of 10% aqueous sodium bisulfate. The organic portion was separated and the aqueous portion was extracted two times with 100 mL each of dichloromethane. The combined organics were dried (Na2SO4) i filtered and concentrated in vacuo. The residue was recrystallized from petroleum ether and dried in vacuo to afford 12.2 g (59%) N-t-butyl methanesulfonamide. Scheme III, step B: To a -78°C solution of 0.7 g (4.7 mmol) of N-t-butyl methanesulfonamide (from step A above) in 15 mL of tetrahydrofuran was added 6.1 mL (9.77 mmol) of 1.6 M n-butyllithium in tetrahydrofuran slowly. The mixture was allowed to warm to 0°C over one hour. The mixture was cool to -78°C and a solution of 1.0 g (5.0 mmol) of 4-bromoacetophenone in 8 mL of tetrahydrofuran was added over 5 minutes. The mixture was warmed to room temperature over one hour and quenched with 10 mL of water. The mixture was extracted three times with 10 mL each of diethyl ether and the combined organics were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (50 g of silica gel, 20% ethyl acetate/hexanes) of the residue afforded 0.9 g (49%) of the title compound. Field Desorption Mass Spectrum: M+1 = 351. Analysis calculated for Ci3H2oNO3BrS: %C, 44.58; %H, 5.76; %N, 4.00. Found: %C, 44.60; %H, 5.51 ; %N, 4.02. Example 3 Preparation of 2-(4-bromophenyl)propanesulfonamide. Scheme III, step C: To a solution of 0.8 g (2.23 mmol) of N-t-butyl-2-(4- bromophenyl)-2-hydroxypropanesulfonamide (prepared in example 2) in 6 mL of dichloromethane was added 0.8 g (6.7 mmol) of trifluoroacetic acid. To this mixture was added 0.3 g (4.5 mmol) of triethylsilane and the mixture was stirred at room temperature for two hours. To the mixture was added 0.3 mL (4.5 mmol) more of triethylsilane and the mixture was heated to reflux for 16 hours. The mixture was cooled to room temperature and concentrated in vacuo. Chromatography (50 g of silica gel, 30% ethyl acetate/hexanes) of the residue afforded 0.27 g (44%) of the title compound. Field Desorption Mass Spectrum: M-1 = 277. Analysis calculated for CgHi2NO2BrS: %C, 38.86; %H, 4.35; %N, 5.04. Found: %C, 39.24; %H, 4.30; %N, 5.09. Example 4 Preparation of N-methyl-2-(4-(2-fluorophenyl)phenyl)propanesulfonamide. A. 4-(2-fluorophenyl)acetophenone: To a degassed solution of 10.0 g (50.2 mmol) of 4-bromoacetophenone, 10.5 g (75.3 mmol) of 2-fluorobenzeneboronic acid and 10.4 g (75.3 mmol) of potassium carbonate was added 4.4 g (3.8 mmol) of tetrakis(triphenylphosphine)palladium(0). The mixture was heated to 100°C for 16 hours, cooled to room temperature and diluted with 50 mL of water. The mixture was extracted three times with 100 mL each of diethyl ether and the combined organics were dried (MgSO ), filtered and concentrated in vacuo. Chromatography (600 g of silica gel, 10% ethyl acetate/hexanes) of the residue afforded 6.2 g (58%) of 4-(2-fluorophenyl)acetophenone. B. 2-(4-(2-fluorophenyl)phenyl)methoxypropene: To a 0°C suspension of 14.7 g (43.0 mmol) of methoxymethyltriphenylphosphonium chloride in 60 mL of tetrahydrofuran was added 43.0 mL (43.0 mmol) of 1.0 M sodium bis(trimethylsilyl)amide in tetrahydrofuran and the mixture stirred for 20 minutes. To the mixture was added 6.1 g (mmol) of 4-(2-fluorophenyl)acetophenone in 20 mL of tetrahydrofuran and the mixture was stirred at 0°C for two hours. To the mixture was added 75 mL of water and the mixture was extracted three times with 50 mL each of diethyl ether. The organics were dried (MgSO ), filtered and concentrated in vacuo. The residue was dissolved in 30 mL of dichloromethane and filtered through three inches of silica gel in a 350 mL sintered glass funnel eluting with 25% ethyl acetate/hexanes. The filtrate was concentrated in vacuo to afford 7.0 g (100%) of 2-(4-(2-fluorophenyl)phenyl)methoxypropene. C. 2-(4-(2-fluorophenyl)phenyl)propionaldehyde: To a solution of 7.0 g (28.8 mmol) of 2-(4-(2-fluorophenyl)phenyl)methoxypropene in 130 mL of acetonitrile was added 35 mL of 1 N hydrochloric acid. The mixture was stirred at room temperature for 16 hours. To this mixture was added 10 mL of 5 N hydrochloric acid and stirring was continued for 16 hours. To the mixture was added 100 mL of brine and the mixture was extracted four times with 100 mL each of diethyl ether. The organics were dried (MgSO 4 ), filtered and concentrated in vacuo. Chromatography (300 g of silica gel, 5% ethyl acetate/hexanes) of the residue afforded 4.4 g (67%) of 2-(4-(2-fluorophenyl)phenyl)propionaldehyde. D. 2-(4-(2-fluorophenyl)phenyl)propanol: To a 0°C solution of 4.4 g (19.3 mmol) of 2-(4-(2-fluorophenyl)phenyl)propionaldehyde in 70 mL of ethyl alcohol was added 0.7 g (19.3 mmol) of sodium borohydride and the mixture was allowed to warm to room temperature over 16 hours. The reaction mixture was concentrated in vacuo and partitioned between 50 mL of ethyl acetate and 50 mL of water. The organic portion was separated and the aqueous portion was extracted three times with 30 mL each of ethyl acetate. The combined organics were dried (MgSO ), filtered and concentrated in vacuo to afford 4.2 g (94%) of 2-(4-(2-fluorophenyl)phenyl)propanol. E. 1-bromo-2-(4-(2-fluorophenyl)phenyl)propane: To a 0°C solution of 7.7 g (29.3 mmol) of triphenylphosphine in 45 mL of dichloromethane was added bromine until a pale yellow color persisted. Add to this mixture was just enough triphenylphosphine to dissipate the yellow color. To this mixture was added 4.2 g (18.2 mmol) of 2-(4-(2-fluorophenyl)phenyl)propanol and 2.3 g (29.3 mmol) of pyridine in 15 mL of dichloromethane. This mixture was stirred at 0°C for one hour and allowed to warm to room temperature over one hour. The reaction mixture was washed once with 40 mL of 10% aqueous sodium bisulfate. The organic portion was separated and the aqueous portion was extracted two times with 25 mL each of dichloromethane. The combined organics were dried (Na 2 SO 4 ), filtered and concentrated in vacuo. Chromatography (150 g of silica gel, hexanes) of the residue afforded 4.8 g (90%) of 1 -bromo-2-(4-(2- fluorophenyl)phenyl)propane. F. S-2-(4-(2-fluorophenyl)phenyl)propylthiuronium acetate was prepared in a manner analogous to the procedure described in example 1 , Part A, starting from the product of part E above. G. 2-(4-(2-fluorophenyl)phenyl)propanesulfonyl chloride was prepared in a manner analogous to the procedure described in example 1 , Part B, starting from the product of part F above. H. To 10 mL of 40% aqueous methylamine was added 0.3 g (1.0 mmol) of 2- (4-(2-fluorophenyl)phenyl)propanesulfonyl chloride above in 3 mL of tetrahydrofuran and the mixture stirred at room temperature for 16 hours. The reaction mixture was extracted three times with 5 mL each of ethyl acetate. The combined organics were dried (MgSO ), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 35% ethyl acetate/hexanes) of the residue afforded 0.1 g (42%) of the title compound. Field Desorption Mass Spectrum: M = 307. Example 5 Preparation of N-ethyl-2-(4-(2-fluorophenyl)phenyl)propanesulfonamide. The title compound was prepared in a manner analogous to the procedure described in example 4, Part H, and using 1.0 mL (2.1 mmol) of 2 M ethylamine in tetrahydrofuran to afford 0.1 g (31 %). Field Desorption Mass Spectrum: M = 321. Example 6 Preparation of N-(2-propyl)-2-(4-(2-fluorophenyl)phenyl)propanesulfonamide. The title compound was prepared in a manner analogous to the procedure described in example 4, Part H, and using 2-propylamine to afford 0.1 g (34%). Field Desorption Mass Spectrum: M = 335. Example 7 Preparation of N,N-dimethyl-2-(4-(2-fluorophenyl)phenyl)propanesulfonamide. The title compound was prepared in a manner analogous to the procedure described in example 4, Part H and using dimethylamine to afford 0.1 g (37%). Field Desorption Mass Spectrum: M = 321. Example 8 Preparation of N-(N',N'-dimethylpropyl)-2-(4-(2-fluorophenyl)phenyl)propane- sulfonamide. The title compound was prepared in a manner analogous to the procedure described in example 4, Part H and using N,N-dimethylaminopropylamine to afford 0.1 g (23%). Field Desorption Mass Spectrum: M = 378. Example 9 Preparation of N-t-butyl-2-(4-(2-fluorophenyl)phenyl)propanesulfonamide. The title compound was prepared in a manner analogous to the procedure described in example 4, Part H and using t-butylamine to afford 0.1 g (31 %). Field Desorption Mass Spectrum: M = 349. Additional compounds included within the scope of the present invention include but are not limited to those listed in Table I. The compounds illustrated in Table I can be readily prepared by one of ordinary skill in the art using standard techniques and methods well known in the art in a manner analogous to the procedures described herein from readily available starting materials and from starting materials specifically described hereinabove. Table

Claims: WE CLAIM: 1. A compound of the formula: wherein R 1 represents a naphthyl group or a phenyl, furyl, thienyl or pyhdyl group which is unsubstituted or substituted by one or two substituents selected independently from halogen; nitro; cyano; hydroxyimino; (1-10C)alkyl; (2-10C)alkenyl; (2- 10C)alkynyl; (3-8C)cycloalkyl; hydroxy(3-8C)cycloalkyl; oxo(3-8C)cycloalkyl; halo(1-10C)alkyl; (CH2)yX 1 R 9 in which y is 0 or an integer of from 1 to 4, X 1 represents O, S, NR 10 , CO, COO, OCO, CONR 1 , NR 2 CO, NR 12 COCOO or OCONR 1 3 , R 9 represents hydrogen, (1 -10C)alkyl, (3-10C)alkenyl, (3- 10C)alkynyl, pyrrolidinyl, tetrahydrofuryl, morpholino or (3-8C)cycloalkyl and R 1 °- R 1 1 • R 12 and R 1 3 each independently represents hydrogen or (1 - 10C)alkyl, or R 9 and R 10 . R > R 12 or R 13 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group; N-(1-4C)alkylpiperazinyl; N-phenyl(1-4C)alkylpiperazinyl; thienyl; furyl; oxazolyl; isoxazolyl; pyrazolyl; imidazolyl; thiazolyl; py dyl; pyridazinyl; pyrimidinyl; dihydro-thienyl; dihydrofuryl; dihydrothiopyranyl; dihydropyranyl; dihydrothiazolyl; (1-4C)alkoxycarbonyldihydrothiazolyl; (1- 4C)alkoxycarbonyldimethyldihydrothiazolyl; tetrahydro-thienyl; tetrahydrofuryl; tetrahydrothiopyranyl; tetrahydropyranyl; indolyl; benzofuryl; benzothienyl; benzimidazolyl; and a group of formula R 14 -(L a ) n -X 2 -(L b )m in which X 2 represents a bond, O, NH, S, SO, SO2, CO, CH(OH), CONH, NHCO, NHCONH, NHCOO, COCONH, OCH2CONH or CH=CH, L a and L b each represent (1 - 4C)alkylene, one of n and m is 0 or 1 and the other is 0, and R 14 represents a phenyl or heteroaromatic group which is unsubstituted or substituted by one or two of halogen, nitro, cyano, hydroxyimino, (1 -1 OC) alkyl, (2-10C)alkenyl, (2- 10C)alkynyl, (3-8C)-cycloalkyl, 4-(1 ,1 -dioxotetrahydro-1 ,2-thiazinyl), halo(1- 10C)alkyl, cyano(2-10C)alkenyl, phenyl, and (CH2)zX 3 R 15 in which z is 0 or an integer of from 1 to 4, X 3 represents O, S, NR 16 , CO, CH(OH), COO, OCO, CONR 17 , NR 8 CO, NHSO2, NHSO2NR 17 , NHCONH, OCONR 1 9 or NR 1 9 COO, R 15 represents hydrogen, (1 -10C)alkyl, phenyl(1 -4C)alkyl, halo(1 - 10C)alkyl, (1 -4C)alkoxycarbonyl(1 -4C)alkyl, (1 -4C)alkylsulfonylamino(1 -4C)alkyl, (N-(1-4C)alkoxycarbonyl)(1 -4C)alkylsulfonylamino-(1 -4C)alkyl, (3-10C)alkenyl, (3-10C)alkynyl, (3-8C)-cycloalkyl, camphoryl or an aromatic or heteroaromatic group which is unsubstituted or substituted by one or two of halogen, (1-4C)alkyl, (1-4C)haloalkyl, di(1 -4C)alkylamino and (1-4C)alkoxy and R 16 , R 17 , R 1 8 and R 1 9 each independently represents hydrogen or (1-10C)alkyl, or R 1 5 and R 16 , R 17 , R 1 or R 1 9 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group; R 2a and R each independently represent hydrogen, (1-6C)alkyl, (3- 6C)cycloalkyl, fluoro(1-6C)alkyl, chloro(1 -6C)alkyl, (2-6C)alkenyl, (1- 4C)alkoxy(1 -4C)alkyl, (1 -6C)alkylN(1 -4C)alkyl 2 , (1 -6C)alkylO(1 -6C)alkyl, -CH 2 furyl, (3-6C)cycloalkyl(1 -6C)alkyl, (phenyl) 2 (1-6C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1 -4C)alkoxy or (3- 6C)cycloalkyl, phenyl(1-6C)alkyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy, or (3-6C)cycloalkyl, naphthyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy or (3- 6C)cycloalkyl, naphthyl(1-6C)alkyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy or (3-6C)cycloalkyl, or R 2a and R 2b together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and either one of R^, R^, R 7 and R 8 represents hydrogen, (1 -6C)alkyl; aryl(1- 6C)alkyl; (2-6C)alkenyl; aryl(2-6C)alkenyl or aryl, or two of R 5 , R 6 , R 7 and R 8 together with the carbon atom or carbon atoms to which they are attached form a (3-8C) carbocyclic ring; and the remainder of R5 R6, R 7 and R 8 represent hydrogen; or a pharmaceutically acceptable salt thereof. 2. A compound according to claim 1 wherein R 2a and R 2b each independently represent hydrogen, (1 -6C)alkyl, phenyl or -CH 2 C 6 H 5 . 3. A compound according to claim 1 wherein R 2a and R 2b each independently represent hydrogen, methyl, ethyl, 2-propyl, t-butyl, phenyl, or - A compound according to claim 1 wherein R 2a represents hydrogen and R ι2b represents (1-6C)alkyl, phenyl or -CH 2 C 6 H 5 . 5. A compound according to claim 1 wherein R 6 and R 7 represent hydrogen. 6. A compound according to claim 1 wherein R 5 and R 8 are each independently hydrogen or (1-4C)alkyl, or together with the carbon atom to which they are attached form a (3-8C) carbocyclic ring. 7. A compound as claimed in any one of claims 1 to 6 wherein R 8 5 represents methyl and R^ represents hydrogen. 8. A compound as claimed in Claim 1 , which is selected from: N-(2-propyl)-1-(2-phenylpropanesulfonamide); o 2-(4-bromophenyl)propanesulfonamide; N-methyl-2-(4-(2-fluorophenyl)phenyl)propanesulfonamide; N-ethyl-2-(4-(2-fluorophenyl)phenyl)propanesulfonamide; N-(2-propyl)-2-(4-(2-fluorophenyl)phenyl)propanesulfonamide; N,N-dimethyl-2-(4-(2-fluorophenyl)phenyl)propanesulfonamide; N-(N',N'-dimethylpropyl)-2-(4-(2-fluorophenyl)phenyl)propanesulfonamide; N-t-butyl-2-(4-(2-fluorophenyl)phenyl)propanesulfonamide; and pharmaceutically acceptable salts thereof. 9. A pharmaceutical composition, which comprises a compound as claimed in claim 1 and a pharmaceutically acceptable diluent or carrier. 10. A method of potentiating glutamate receptor function in a mammal requiring such treatment, which comprises administering an effective amount of a compound of formula: wherein R 1 represents an unsubstituted or substituted aromatic or heteroaromatic group; R 2a and R 2b each independently represent hydrogen, (1-6C)alkyl, (3- 6C)cycloalkyl, fluoro(1-6C)alkyl, chloro(1-6C)alkyl, (2-6C)alkenyl, (1- 4C)alkoxy(1-4C)alkyl, (1-6C)alkylN(1 -4C)alkyl 2 , (1-6C)alkylO(1-6C)alkyl, -CH 2 furyl, (3-6C)cycloalkyl(1 -6C)alkyl, (phenyl) 2 (1-6C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy or (3- 6C)cycloalkyl, phenyl(1-6C)alkyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy, or (3-6C)cycloalkyl, naphthyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy or (3- 6C)cycloalkyl, naphthyl(1-6C)alkyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy or (3-6C)cycloalkyl, or R 2a and R 2b together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and either one of R 5 , R 6 , R 7 and R 8 represents hydrogen, (1-6C)alkyl; aryl(1 - 6C)alkyl; (2-6C)alkenyl; aryl(2-6C)alkenyl or aryl, or two of R 5 , R 6 , R 7 and R 8 together with the carbon atom or carbon atoms to which they are attached form a (3-8C) carbocyclic ring; and the remainder of R 5 , R6, R 7 and R 8 represent hydrogen; or a pharmaceutically acceptable salt thereof. 11. A method of potentiating glutamate receptor function in a mammal requiring such treatment, which comprises administering an effective amount of a compound of claim 1. 12. A method of treating a cognitive disorder; a neuro-degenerative disorder; age-related dementia; age-induced memory impairment; movement disorder; reversal of a drug-induced state; depression; attention deficit disorder; attention deficit hyperactivity disorder; psychosis; cognitive deficits associated with psychosis; or drug-induced psychosis in a patient, which comprises administering to a patient in need thereof an effective amount of a compound of formula: wherein R 1 represents an unsubstituted or substituted aromatic or heteroaromatic group; R 2a and R 2b each independently represent hydrogen, (1-6C)alkyl, (3- 6C)cycloalkyl, fluoro(1 -6C)alkyl, chloro(1-6C)alkyl, (2-6C)alkenyl, (1- 4C)alkoxy(1-4C)alkyl, (1-6C)alkylN(1-4C)alkyl 2 , (1-6C)alkylO(1-6C)alkyl, -CH 2 furyl, (3-6C)cycloalkyl(1-6C)alkyl, (phenyl) 2 (1-6C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy or (3- 6C)cycloalkyl, phenyl(1-6C)alkyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy, or (3-6C)cycloalkyl, naphthyl which is unsubstituted or substituted by halogen, (1 -4C)alkyl, (1 -4C)alkoxy or (3- 6C)cycloalkyl, naphthyl(1 -6C)alkyl which is unsubstituted or substituted by halogen, (1 -4C)alkyl, (1 -4C)alkoxy or (3-6C)cycloalkyl, or R 2a and R 2b together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and either one of R 5 , R 6 , R 7 and R 8 represents hydrogen, (1 -6C)alkyl; aryl(1 - 6C)alkyl; (2-6C)alkenyl; aryl(2-6C)alkenyl or aryl, or two of R 5 , R 6 , R 7 and R 8 together with the carbon atom or carbon atoms to which they are attached form a (3-8C) carbocyclic ring; and the remainder of R 5 , R 6 , R 7 and R 8 represent hydrogen; or a pharmaceutically acceptable salt thereof. 13. A method of treating a cognitive disorder; a neuro-degenerative disorder; age-related dementia; age-induced memory impairment; movement disorder; reversal of a drug-induced state; depression; attention deficit disorder; attention deficit hyperactivity disorder; psychosis; cognitive deficits associated with psychosis; or drug-induced psychosis in a patient, which comprises administering to a patient in need thereof an effective amount of a compound according to claim 1 . 14. A method for improving memory or learning ability in a patient, which comprises administering to a patient in need thereof an effective amount of a compound of formula: wherein R 1 represents an unsubstituted or substituted aromatic or heteroaromatic group; R 2a and R 2b each independently represent hydrogen, (1-6C)alkyl, (3- 6C)cycloalkyl, fluoro(1-6C)alkyl, chloro(1-6C)alkyl, (2-6C)alkenyl, (1- 4C)alkoxy(1 -4C)alkyl, (1 -6C)alkylN(1 -4C)alkyl 2 , (1 -6C)alkylO(1 -6C)alkyl, -CH 2 furyl, (3-6C)cycloalkyl(1-6C)alkyl, (phenyl) 2 (1 -6C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy or (3- 6C)cycloalkyl, phenyl(1 -6C)alkyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy, or (3-6C)cycloalkyl, naphthyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy or (3- 6C)cycloalkyl, naphthyl(1 -6C)alkyl which is unsubstituted or substituted by halogen, (1-4C)alkyl, (1-4C)alkoxy or (3-6C)cycloalkyl, or R 2a and R 2b together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and either one of R^, R6, R 7 and R 8 represents hydrogen, (1-6C)alkyl; aryl(1- 6C)alkyl; (2-6C)alkenyl; aryl(2-6C)alkenyl or aryl, or two of R 5 , R 6 , R 7 and R 8 together with the carbon atom or carbon atoms to which they are attached form a (3-8C) carbocyclic ring; and the remainder of R 5 , R 6 , R 7 and R 8 represent hydrogen; or a pharmaceutically acceptable salt thereof. 15. A method for improving memory or learning ability in a patient, which comprises administering to a patient in need thereof an effective amount of a compound according to claim 1.

Inventors: ARNOLD MACKLIN BRIAN, ORNSTEIN PAUL LESLIE, SMITH EDWARD C R, ZARRINMAYEH HAMIDEH, ZIMMERMAN DENNIS MICHAEL, ARNOLD, MACKLIN, BRIAN, ORNSTEIN, PAUL, LESLIE, SMITH, EDWARD, C., R., ZARRINMAYEH, HAMIDEH, ZIMMERMAN, DENNIS, MICHAEL
Applicants: ARNOLD MACKLIN BRIAN, LILLY CO ELI, ORNSTEIN PAUL LESLIE, SMITH EDWARD C R, ZARRINMAYEH HAMIDEH, ZIMMERMAN DENNIS MICHAEL, ARNOLD, MACKLIN, BRIAN, ELI LILLY AND COMPANY, ORNSTEIN, PAUL, LESLIE, SMITH, EDWARD, C., R., ZARRINMAYEH, HAMIDEH, ZIMMERMAN, DENNIS, MICHAEL
Application year: 1999
Main classification: A61K31
IPC codes: A61K31, A61P25, A61P43, C07C311, C07D307