USE OF VITAMIN PP COMPOUNDS

Abstract: The invention relates to the use of vitamin PP compounds and/or compounds with anti-pellagra activity such as for example nicotinic acid (niacin), and nicotinamide (niacin-amide, vitamin PP, vitamin B3) for the reduction, elimination or prevention of side-effects of different degrees as well as for neutralization of acute side-effects in immunosuppressive or cancerostatic chemotherapy or diagnosis, especially with substituted pyridine carboxamides, whereby compounds from the series of formula (I), as well as combination medicaments with an amount of compounds with vitamin B3 and/or anti-pellagra activity and chemotherapeutic agents are especially considered in the mentioned chemotherapies and indications.

Description: Use of Vitamin PP Compounds The invention relates to the use of vitamin PP compounds ("PP » = pellagra preventing activity) and/or compounds with anti-pellagra activity such as, for example, nicotinic acid (niacin) , and nicotinamide (niacinamide, vitamin PP, vitamin B3) for the reduction, elimination or prevention of side- effects of different degrees of severity as well as for the neutralization of acute side-effects in immunosuppressive or cancerostatic chemotherapy or diagnostics, especially with substituted pyridine carboxamides as tumor inhibitors, optionally in combination with radiation therapy. Nicotinamide is the most important building block for synthesis and maintenance of cellular stores of nicotinamide adenine dinucleotide (NAD) . In gram amounts, it has a relatively low toxicity (Zackheim, H.S., Vasily, D.B. and Hastings C.W. : Reactions to niacinamide. J. Am. Acad. Dermatol. : 736-737, 1981), whereby its therapeutic priority in clinical use is to be seen in treatment of pellagra; see Green, R.C. : Subclinical pellagra: its diagnosis and treatment in Schizophrenia 2; 70-79, 1970. Nicotinamide was further used in order to cure the symptoms of schizophrenia Greenjaum, G.H.C.: An evaluation of niacinamide in the treatment of childhood schizophrenia or Am. J. Psychiatry 127: 89-92, 1970) . Clinical tests for preventing type I diabetes mellitus have been undertaken; see Elliot, R.B. and Chase, H.P.: Prevention of delay of type I (insulin- dependent) diabetes mellitus in children using nicotinamide in Diabetologica 3_5: 362-365, (1991) . The NAD synthesized from nicotinic acid or nicotinamide is important for the cellular production of adenosine triphosphate (ATP) , the maintenance of the redox potential of cells and as a substrate for poly (ADP-ribose) -polymerase (PARP, EC 2.4.2.30) and the other reactions carried out by ADP-Ribose (Althaus, F.R. and Richter, C. : ADP-ribosylation of Proteins : Enzymology and Biological Significance, Springer Verlag, Berlin 1987) . PARP is an enzyme which binds to DNA whose activity plays a role in DNA-repair, cell proliferation, apoptosis, cell differentiation and attending to the genome . For some time, the administration of nicotinamide for increasing the sensitivity of tumors to chemotherapy and/or radiation therapy has been tested in pre-clinical and clinical studies (Kaanders, J.H.A.M., Pop, L.A.M. , Marres, H.A.M. , van der Maazen, R.W.M. , van der Kogel, A.J. and van Daal, W.A.J.: Radiotherapy with carbogen and nicotinamide in head and neck cancer: feasibility and toxicity; Radiother. Oncol. 37: 190-198, 1995) . Two effects are discussed in the literature as a mechanism for the sensitizing properties of nicotinamide: First, nicotinamide could lead to greater blood circulation through tumor tissue {Horsman, M.R., Chaplin, D.J. and Brown, J.M. : Tumor radiosensitization by nicotinamide: a result of improved blood perfusion and oxygenation. Rad. Res. 1181 : 139 -150, 1989; Chaplin, D.J., Horsman, M.R. and Aoki , D.S.: Nicotinamide, fluosol DA and carbogen: a strategy to reoxygenate acutely and chronically hypoxic cells in vivo; Br. J. Cancer 63_: 109 - 113, 1991; Powell, M.E.B., Hill, S.A., Saunders, M.I., Hoskin, P.J. and Chaplin, D.J.: Human Tumor Blood Flow Is Enhanced by Nicotinamide and Carbogen Brea thing. Cancer Research 57_ : 5261 -5264 , 1997) . Hypoxic, under-supplied tumor cells could be stimulated to grow through better supply with oxygen (especially by the inhalation of high-percent oxygen/CC>2 gas mixed carbogene) and nutrients which, in turn, would make them more susceptible to the actions of cytostatic agents and radiation. Second, nicotinamide could cause an inhibition of the enzyme PARP, the latter playing a role in the repair of DNA damage as mentioned above. ( Ben Hur, E. , Utsumi , H. and Elkind, M. M. : Inhibi tors of poly (ADP-ribose) synthesi s enhance X-ray killing of log-phase Chinese hamster cell in Radia t . Res . 97 : 546-555, 1984 ; George, A. M. , Lunec , J. , Cramp, VI. A. , Brennan, S . , Lewis, P. D. and Wish , W. J. D. : The effects of benzamide ADP-ribosyl transferase inhibi tors on cell survi val and DNA strand-break repair in irradiated mammalian cell s in Tnt. J. Radia t . Biol . 49 : 783 - 798, 1986) . This enzyme uses the cellular pyridine nucleotide NAD as a substrate and transfers its ADP-ribose portion to other proteins whose function is regulated in this manner. Therewith, the DNA damage produced by cytostatic agents or radiation should lead more quickly to cell death by inhibition of PARP. Previously, a series of medicaments have already been proposed for combating the considerable side-effects arising from cancerostatic chemotherapy such as, for example, dopamine antagonists, for example, chlorpromazine, droperidol, fluphenazine and other compounds, such as antihistamines such as, for example, buclizine, cyclizine, dimenhydrinate or promethazine . Benzquinamide and tronabinol or diphenidol or trimethobenzamide have also been used for this purpose for the therapy of side-effects of cancerostatic agents. However, massive side-effects can be ascribed to these medicinals themselves as is well-known by experts. These agents for the alleviation of side-effects such as, for example, haloperidol, methoclopramide, ondansetrone or domperidone are mainly used against severe nausea and vomiting caused by chemotherapy. Folic acid represents a very specific remedy which can only be administered in connection with methotrexate for reduction of its side- effects in the case of chemotherapeutic treatment. Therefore, it is an object to find a method which helps to suppress neutralize or at least reduce, to a degree which is easy to bear for patients, the side-effects of different degrees of severity associated with chemotherapy, especially of tumors, or with the chemotherapeutic immunosuppression or with prevention of metastasis formation or anti-proliferative treatment with pharmaceuticals. A further object is also to entirely eliminate the side- effects which are already reduced in comparison to customary tumor inhibitors of the compounds according to the general formula (I), and, in individual cases, to still further diminish particular individual patient sensitivity. Surprisingly, it has now been found that, in contrast to the effects and/or effectiveness-increasing activities of nicotinic acid or nicotinic acid amide in connection with radiation therapy discussed at the beginning, these compounds can be used for preventing side-effects or neutralizing the cell growth-inhibiting activity of cancerostatic and/or tumor-inhibiting chemotherapeutic agents based on an opposing effect which has not yet been explained scientifically. In an unexpected manner, the inventors have now established that by using compounds with vitamin PP activity, side- effects of different degrees of severity which are associated with cancerostatic chemotherapy, for example, with the tumorstatic agents according to the general formula (I) can be reduced, eliminated or prevented. The use according to the invention and/or the medicaments according to the invention have the advantage that the compounds with vitamin PP activity used for the elimination of side-effects, especially according to the general formula (II) to (Vb) , themselves do not cause new side-effects. This finding is surprising in view of the previous art in the field of cancerostatic chemotherapy. The unexpected effect could be traced back to a new biochemical mechanism of which no decisive clarity exists at the present time point. Hence, the invention relates to the use of compounds with vitamin PP activity as a cyto-protective agents for the prevention, reduction or elimination of side-effects and/or neutralization of the effects of cancerostatic agents or immunosuppressive agents, especially of compounds from the series of substituted pyridylalkane, pyridylalkene and pyridylalkine acid amides of the general formula (I), in diagnostics or cytostatic or immunosuppressive chemotherapy, optionally in combination with radiation therapy. Furthermore, it relates to the use of vitamins of the group PP as cyto-protective agents production of medicaments for prevention, reduction or elimination of side-effects and/or neutralization of the effects of cancerostatic agents or immunosuppressive agents, especially compounds from the series of substituted pyridylalkane, pyridylalkene and pyridylalkine acid amides in diagnostics or cytostatic, anti- proliferative or immunosuppressive chemotherapy, optionally in combination with radiation therapy. The use according to the invention in the application of compounds of the general formula (I) can also be in connection with their administration as an abortive agent. The invention is characterized in a preferred manner in that nicotinic acid or nicotinamide and/or their pharmocologically and pharmaceutically acceptable ester derivatives, anionic or quaternary salts or addition salts, N-oxides, optionally their analogous thioxo derivatives or optical isomers as well as their prodrugs, are used as a compound or compounds with vitamin PP activity, and pyridylalkane, pyridylalkene and pyridylalkine carboxamides of the following general formula (I) ,0 ) are used as cancerostatic agents and/or tumor inhibitors or immuosuppressive agents, wherein the residues R- 1 ' 1 ', R2(!) , R 3 (i) and R 4 (i) are selected from halogen, hydroxy, trifluoromethyl, cyano, aliphatic hydrocarbon residues optionally substituted with functional groups, optionally interrupted by one or more hetero-atoms, or aromatic hydrocarbon residues, whereby, R 1 ^) and R 2 ^ 1 ) can form a bridge together, k is the number 0 or 1, and Ad) and D(Ϊ) signify an aliphatic, saturated or unsaturated, optionally substituted, hydrocarbon residue which can optionally be interrupted by a hetero-atom or a functional group. E is a bond or a heterocycle with either one or two N-atoms or an N-atom plus an O-atom, whereby their linkage with D^i ) and G either occurs over a nitrogen atom and a carbon atom or optionally over both ring nitrogen atoms; G is selected from hydrogen or an aliphatic or araliphatic residue, an unsaturated or aromatic, mono- or polycyclic carbocyclic residue, a saturated, unsaturated or aromatic, mono- or polycyclic heterocyclic residue, which can be bound directly or over a functional group derived from C-, N-, 0-, S- or P-atoms, for example, an ether, thioether, acyl, sulfonyl, phosphinoyl group, or an amide, carbamate, ureide, sulfonamide or phosphinamide group, or a mono- or polycyclic imide bound over the imide nitrogen atom, as well as their stereoisomers including cis/trans-isomers, E/Z-isomers, enantiomers, as well as diastereomers and other isomers of the above defined compounds, in optionally pure form or as their racemic and/or non-racemic mixtures; as well as the tautomers of the above defined compounds in the optional case that G represents a heterocyclic aromatic ring or which contains one which simultaneously contains substitution by free hydroxy, mercapto or amino groups; as well as the corresponding pharmacologically acceptable acid addition salts of the above defined compounds, for example, with organic acids such as acetates, benzoates, citrates, fumarates, gluconates, malates, maleates, methanesulfonates, lactates, oxalates, succinates, tartrates and tosylates or inorganic acids such as hydrochlorides, hydrobromides, hydroiodides, sulfates and phosphates including their hydrates and solvates. In a preferred manner according to the invention, the following groups of compounds according to the general formula (I) are employed in connection with the cancerostatic and other chemotherapies and/or diagnostics named above: Pyridylalkane, pyridylalkene and pyridylalkine acid amides of the formula (I) R 3 (i) o N β) R 4 (i) (I) wherein R 1 ) is selected from hydrogen, halogen, cyano, alkyl, alkenyl or alkinyl, especially C^-Cg-alkyl, C3-Cβ-alkenyl or C2-Cβ-alkinyl, trifluoromethyl, hydroxy, cycloalkyl, hydroxyalkyl, alkoxy, alkenyloxy or alkinyloxy, especially C3~Cg-cycloalkyl, Cχ-Cg- hydroxyalkyl, Ci-Cg-alkoxy, C3-Cβ-alkenyloxy or C3-C5- alkinyloxy, aralkyloxy such as benzyloxy, alkanoyloxy, alkoxycarbonyloxy, alkylthio, alkenylthio, alkinylthio, cycloalkyloxy, cycloalkylthio or alkoxy- carbonyl, especially C_-C7-alkanoyloxy, C-2-C7-alkoxy- carbonyloxy, C_-Cg-alkylthio, C3-Cg-alkenylthio, C3-Cg-alkinylthio, C3-Cg-cycloalkyloxy, C3-Cg-cyclo- alkylthio or C2~C7-alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylamino- carbonyl, especially C2-C7-alkylaminocarbonyl or C3-C]_3-dialkylaminocarbonyl, carboxy, phenyl, aryloxy such as phenoxy, arylthio such as phenylthio, heteroaryloxy such as pyridyloxy, heteroarylthio such as pyridylthio, and NR 5 ( R 6 ( , whereby the residues R^ ) and R^ ) are selected independently from each other from hydrogen, alkyl, alkenyl or alkinyl, especially Cι_- Cg-alkyl, C3-Cg-alkenyl or C3-Cg-alkinyl, aralkyl such as benzyl and aryl such as phenyl; R^ ) is selected from hydrogen, halogen, cyano, alkyl, especially C_-Cg-Alkyl, trifluoromethyl, hydroxy, alkoxy, especially C^-Cg- alkoxy, aralkyl such as benzyloxy and alkanoyloxy, especially C]_-C7~alkanoyloxy; R and R^ ) optionally form a bridge when they are adjacent, selected from -(CH 2 )4- and - (CH=CH) - and -CH 2 0-CR 7 ( i )R 8 ( i )-0-, whereby R * 7( and R 8 (') are selected independently from each other from hydrogen and alkyl, especially Cι_-Cg-alkyl; R3( selected is from hydrogen, halogen, alkyl, especially C^-Cg-alkyl, trifluoromethyl and hydroxyalkyl, especially C]_-Cg- hydroxyalkyl ; R^ ) is selected from hydrogen, hydroxy, alkyl, alkenyl, alkinyl, cycloalkyl or alkoxy, especially C_-Cg-alkyl, C3~Cg-alkenyl, C3~Cg- alkinyl, C3-Cg-cycloalkyl or C^-Cg-alkoxy and aralkyl such as benzyloxy; k is 0 or 1, Av is selected from alkylene, especially C^-Cg-alkylene, optionally substituted one- to three-fold by alkyl or alkoxy, especially C]_-C3~alkyl or C ] _-C3~alkoxy, hydroxy, fluorine, or aryl such as phenyl, C2-Cg-alkylene, wherein a methylene unit is isosterically replaced by 0, S, NR 9 ( , CO, SO or SO2, whereby, with the exception of CO, the isosteric substitution cannot be adjacent to the amide group and R 9 ( is selected from hydrogen, alkyl, alkenyl, alkinyl, acyl or alkanesulfonyl, especially Cι_-Cg-alkyl, C3~Cg- alkenyl, C3-Cg-alkinyl, C]_-Cg-Acyl or Cι_-Cg- alkanesulfonyl, 1, 2-cyclopropylene, C2-Cg-alkenylene, optionally substituted one to threefold by alkyl, especially Cχ-C3-alkyl, hydroxy, alkoxy, especially C_-C3~alkoxy, fluorine, cyano or aryl such as phenyl, C4-Cg-alkadienylene, optionally substituted once to twice by alkyl, especially C ] _-C3~alkyl, fluorine, cyano or aryl such as phenyl, 1, 3, 5-hexatrienylene, optionally substituted by alkyl, especially Cι_-C3-alkyl, fluorine, cyano or aryl such as phenyl, and ethinylene; Dv) is selected from alkylene, especially C]_-Cι_2 _ alkylene, optionally substituted once or twice by alkyl, especially Cι_-Cg- alkyl, hydroxy, alkoxy, especially C^-Cg-alkoxy or aryl such as phenyl, C2-C ] _2~alkenylene or C4-Cι_2 _ alkadienylene, optionally substituted once or twice by alkyl, especially Cι_-Cg- alkyl, hydroxy, alkoxy, especially C]_-Cg-alkoxy or aryl such as phenyl, whereby a double-bond can occur, optionally to the ring in the case that this is linked over a C-atom, C3-Ci2 -a lkinylene or C4-Cι_2~alkeninylene, optionally substituted once or twice by alkyl, especially Cι_-Cg- alkyl, hydroxy, alkoxy, especially C_-Cg-alkoxy or aryl such as phenyl, and alkylene, especially Cχ-C ] _2 _a lkylene, C2 _ Cι_2-alkenylene or C3-Cι_2-alkinylene, wherein, respectively, one to three methylene units, with the exception of the (G)- terminal methylene group in the case that E represents a bond, are isosterically replaced by 0, S, NR lo ), CO, SO or S02 whereby 12 R10( I ) j_ s synonymous with R 9 0), but is selected independently thereof; , ^ l(i) 2(i) 3 4 5 6 is selected from E , E , E , E , E or E , whereby E 1 ! 1 ) signifies the heterocycle E^ ) signifies the heterocycle (CH 2 ) q N ■ ( G ) (D) R 12 ) signifies the heterocycle (C H 2 ) q (D R 2 ) E^ signifies the heterocycle (D)- and signifies the heterocycle RH(i) (G) (D) 12 (i) and E 6 signifies a single or double bond whereby the heterocyclic rings E 1 (') to E 5 can optionally have a double bond and n and p can signify, independently from each other, 0, 1, 2, or 3 with the proviso that, n + p < 4, and q is 1, 2 or 3; R11( is selected from hydrogen, alkyl, especially Cι_-Cg-alkyl, hydroxy, hydroxymethyl, carboxy or C2-C7~alkoxycarbonyl and R 12 ( is selected from hydrogen, alkyl, especially Cχ-Cg-alkyl or an oxo group adjacent to a nitrogen atom, or 14 R 11 (0 and R 12 ( , optionally together, form a Ci-03-al ylene bridge under formation of a bicyclic ring system, or G is selected dependent on the group E, whereby (a) in the case that E has the meanings E , E , or E the substituent G can have the following meanings G 5(i) to G , whereby G Mi) is, (CH 2 ) r — (CRl4(i) R 15(i) ,— R13C .1( , whereby r is 0 to 3 and s is 0 or 1, Rl3(i)j_ s selected from hydrogen, alkyl, alkenyl, alkinyl or cycloalkyl, especially Cχ-Cg-alkyl, C3~Cg-alkenyl, C 3 ~Cg-alkinyl, C3~Cg-cycloalkyl; saturated or unsaturated, four to seven-membered heterocycles which can contain one or two hetero-atoms selected from N and/or S and/or 0; aralkyl such as benzyl, aryl such as phenyl; monocyclic aromatic five or six-membered heterocycles which can contain one to three. hetero-atoms selected from N and/or S and/or 0 and are either bound directly (direct) or over a methylene group; anellated bi- and tricyclic aromatic or partially hydrated carbocyclic ring systems with 8 to 16, 17 or 1! ring atoms and at least one aromatic ring, whereby the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group; anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring systems with 8 to 16, 17 or 18 ring atoms and at least one aromatic ring, v/hereby one to three ring atoms can be selected from N and/or S and/or 0 and the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group; R1 ( has the same meaning as R^ ), but is independently selected from; R15(I) j_ s selected from hydrogen, hydroxy, methyl, aralkyl such as benzyl, aryl such as phenyl, monocyclic aromatic five or six-membered heterocycles which can contain one to three hetero-atoms selected from N and/or S and/or 0 and are either bound directly (direct) or over a methylene group; anellated bi- and tricyclic aromatic or partially hydrated carbocyclic ring systems with 8 to 16, 17 or IE ring atoms and at least one aromatic ring, whereby the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group; anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring systems with 8 to 16, 17 or 18 ring atoms and at least one aromatic ring, whereby one to three ring atoms can be selected from N and/or S and/or 0 and the linkage can occur either over an aromatic or a hydrated ring and either directly (direct) or over a methylene group; G 2 (0 is selected from 16 ■ C — X ( — ( CR^OR 15 c ) s R 13 (») (G 2 ^, or (CH 2 ) r — NR 13(i) R 15(i) ( G 2b(1 ', whereby r and s and the substituents R^ ) to R15( I ) can have the above meanings, or the grouping NR 13(i) R 15(i) can also be a nitrogen heterocycle bound over the nitrogen atom, selected from saturated or unsaturated monocyclic, four to eight- membered heterocycles, which aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from N and/or S and/or 0, or saturated or unsaturated bi- or tricyclic, anellated or bridged heterocycles with 8 to 16, 17 or 18 ring atoms, which aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from N and/or S and/or 0, and x(0 is selected from methylene, ethylene, ethenylene, propylene, C3~C7-cyclo- alkylene, or represents a bond; G^ ) has the meaning, 13(i) S0 2 (CH 2 ) r R 3(i) (G wherein r and R 13 0) have the above meanings, G^( has the meaning, °^Ar2 (G 4(i) ) whereby Ar 1 and Ar 2 are selected independently from each other from phenyl, pyridyl or naphthyl; G 5 * 1) has the meaning, COR ^ (G 5(l) ) whereby pl6(ι) _ s selected from trifluoromethyl, alkoxy and alkenyloxy, especially C^-Cg-alkoxy and C3~Cg-alkenyloxy or aralkyloxy such as benzyloxy, 4 5 (b) in the case that E has the meanings E or E , G can have the meanings G 1(0, G2(0, and G6(0, G-'7 and G8, whereby G and G have the above meanings and G6(0 has the meaning =(C) u R 13(i) R 1δ( (G^O)) whereby R13( and R!5( have the above meanings and u is 0 or 1, or the grouping 15(i) CR 13 bound to E by means of a double bond can also be a ring system bound over the carbon atom in the case that u is 1, selected from lo C3-Cg-cycloalkyl, saturated, four to seven-membered heterocycles that can contain one or two hetero-atoms, selected from N and/or S and/or 0; anellated bi- and tricyclic partially hydrated carbocyclic ring systems with 8 to 16, 17 or 18 ring atoms and at least one aromatic ring; anellated bi- and tricyclic partially hydrated heterocyclic ring systems with 8 to 16, 17 or 18 ring atoms and at least one aromatic ring, whereby one to three ring atoms can be selected from N and/or S and/or 0; or the two geminalsubstituents R! 3 ( and R! 5 ( can form a spirocycle together with the bonding atom of the ring E in the case that u is 0, selected from C3-C8-cycloalkyl, saturated, four to seven-membered heterocycles that can contain one or two hetero-atoms, selected from N and/or S and/or 0; anellated bi- and tricyclic partially hydrated carbocyclic ring systems with 8 to 16, 17 or 18 ring atoms and at least one aromatic ring; anellated bi- and tricyclic partially hydrated heterocyclic ring systems with 8 to 16, 17 or 18 ring atoms and at least one aromatic ring, whereby one to three ring atoms can be selected from N and/or S and/or O; is selected from — NR i7(i) __ (CH 2 ) r — (CR 14 (θR 5 (0) s — R 1 (0 7a (G ) or 19 NR17(0__ c— χ ( W^i) (CR 1 (0Rlδ(0) — R13(0 7b, ( G or NR17(0— c (CH 2 ) r NR 13 (θRis(0 7c (G or ,13(i) NR 17(0 so 2 (CH 2 ), 7d. or NR 17(0 Ari Ar2 7e. (G or — NR1 ( — COR16( (G 7 } whereby r, s and x(0 as well as the substituents R 13 (0, R! 4 (0, R 15 (0 and R 16 (0 and the group — NR^WR 15 ^) can have the above meanings and R 17 (0 has the same meanings as R^ ), but is selected independently thereof, Ar 1 and Ar 2 are selected independently from each other from phenyl, pyridyl or naphthyl; G° has the meaning Y^- (CH 2 ) r —(CR1 CDR15®, R 13(i) 8a or _ γ ® ,,P ° ^Ar2 8b Ar (G ) whereby r and s as well as the substituents R 13 (0, R 14 (0, Rl5(i) r Arl and Ar 2 can have the above meanings and Yv) has the meaning 0 or S; (c) in the case that the substituent E possess the meaning 6 E ,i.e. represents a single or double bond, 7d 7e 8b 9 the substituent G is selected from G , G , G or G 13 7d 7e 8b to G , whereby G , G and G have the above meanings and G y is selected from (CR"(0R19) C .18 9a . or R13( RIB 9b whereby s and R 13 (0 are defined as above and R 18 is selected from benzyl, diphenylmethyl, phenyl; monocyclic aromatic five or six-membered heterocycles that can contain one to three hetero-atoms selected from N and/or S and/or 0 and are either bound directly or over a methylene group; anellated bi- and tricyclic aromatic or partially hydrated carbocyclic ring systems with 8 to 16, 17 or 18 ring atoms and at least one aromatic ring, whereby the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group; anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring systems with 8 to 16, 17 or 18 ring atoms and at least one aromatic ring, whereby one to three ring atoms can be selected from N and/or S and/or 0 and the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group; has the same meanings as R! 3 (0 but is selected independently thereof, but in addition can be hydroxy, or the grouping NR 13(i) R 18 can also be a nitrogen heterocycle bound over the nitrogen atom, selected from anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring systems with 8 to 16, 17 or 18 ring atoms and at least one aromatic ring, which aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from N and/or S and/or 0; represents the grouping = CR 13 ( i )R 18 ,„ιo. 22 bound to D by means of a double bond, wherein R 13 (0 and R!8 have the above meanings, or whereby the grouping = CR 13 «R 18 can also be a ring system bound over the carbon atom, selected from anellated bi- and tricyclic partially hydrated carbocyclic ring systems with 8 to 16, 17 or 18 ring atoms and at least one aromatic ring; anellated bi- and tricyclic partially hydrated heterocyclic ring systems with 8 to 16, 17 or 18 ring atoms and at least one aromatic ring, whereby one to three ring atoms can be selected from N and/or S and/or 0; G 11 is selected from NR 17 © - (CH 2 ) r (CR 13 ^ 19 ). >18 lia. (G or NR 17(i) c χ G-— (CR 13 ( i )Rl 9 ) e 18 lib. or (SIR 17 ® C NR 13(i) R 18 l l c tø (G ' whereby r, s, x(0 and Y(0 as well as the substituents R 13 (0, R 17 (0, R 18 and R 19 as well as the group NR 13 (0R18 can have the above meanings; G-- 2 has the meaning, Y (i^)— . /(ΓCUH 2 .I) r — (rCR1 1 3 3 ((ni) R p1199\ )s R> 1188 12, wherein r, s and γ(0 as well as the substituents R 13 (0, R 18 an d R1 can have the above meanings; is a cyclic imide of the general formula (D) ( ,G 13a ,) or (D)- N o' Oi — ( ,G 13b ) bound to D over the imide nitrogen atom, selected from saturated or unsaturated monocyclic imides with 5 to 7 ring atoms, from which, aside from the essential imide nitrogen atom, one or two further hetero-atoms can be selected from N and/or S and/ or 0; saturated, unsaturated or aromatic anellated, bi-, tri- or tetracyclic imides with 8 to 18 ring atoms, from which, aside from the essential imide nitrogen atom, one or two further hetero-atoms can be selected from N and/or S and/or 0; saturated or unsaturated, bridged bi-, tri-, tetra- or pentacyclic imides with 8 to 22 ring-atoms, from which aside from the essential imide nitrogen atom, one or two further hetero-atoms can be selected from N and/or S and/or 0; saturated or unsaturated spirocyclic imides, optionally anellated one or two-fold, and with a total of 9 to 23 ring atoms, from which, aside from the essential imide nitrogen atom, one or two further hetero-atoms can be selected from N and/or S and/ or 0, whereby these cyclic imides can be substituted by one to five of the same or different groups selected independently from each other from halogen, cyano, alkyl, especially C^-Cg-alkyl, Cχ-Cg- alkylidene, trifluoromethyl, cycloalkyl, especially C3-C8- cycloalkyl, C3-C8-cycloalkylidene, phenyl-C -C3-alkyl, phenyl-Cχ-C3~alkylidene, diphenyl-Cχ-C3~alkyl, diphenyl-C - C3-alkylidene, triphenylmethyl, phenyl, hydroxy, hydroxyalkyl, especially C^-Cg-hydroxyalkyl, alkoxy, especially C ] _-Cg-alkoxy, C -Cg-alkoxy entirely or partially substituted by fluorine, benzyloxy, phenoxy, naphthyloxy, mercapto, alkylthio, especially C]_-Cg-alkylthio, aryl- or heteroarylthio such as phenylthio, naphthylthio or pyridylthio, alkanesulfonyl, especially C]_-Cg-alkanesulfonyl, aryl- or heteroarylsulfonyl such as phenylsulfonyl, naphthylsulfonyl or pyridylsulfonyl, sulfo, carboxy, carboxyalkyl, especially C2~C7-carboxyalkyl, carboxyalkenyl, especially C2-C7-carboxyalkenyl, alkoxycarbonyl, especially C2~C7-alkoxycarbonyl, aralkyloxycarbonyl such as benzyloxycarbonyl, nitro, amino, C -Cg-amino-alkyl, mono- or dialkylamino, especially mono-C ] _-Cg-alkylamino or di-(Cχ-Cg- alkyl) amino, arylamino such as phenylamino, aralkylamino such as phenyl-C]_-C3-alkylamino, heteroarylamino such as pyridylamino, saturated or unsaturated, four to seven-membered heterocycles that can contain one or two hetero-atoms selected from N and/or S and/or 0 and are either bound directly or over a methylene group or a methine group, monocyclic aromatic five or six-membered heterocycles that can contain one to three hetero-atoms, selected from N and/or S and/or 0 and are either bound directly or over methylene group or a methine group, anellated bicyclic, aromatic or partially hydrated carbocyclic ring systems with 8 to 12 ring atoms that are either bound directly over a methylene group or a methine group, anellated bicyclic aromatic or partially hydrated heterocyclic ring systems with 8 to 12 ring atoms, whereby one to three ring atoms can be selected from N and/or S and/or 0 and are either bound directly or over a methylene group or a methine group, and whereby aromatic ring systems in the substituents RM , R 2(i), R4 ), R 5(i), R 6(0, R13 ), R 14(i), R 15(i), RIG^ R 17(i), R 18, R 19 , Ar 1 and Ar 2 , in the groups A(0 and D(0, in the ring = CR 13 (0R1 5 (0 = CR 13 ( J )R 18 NR 13 ^ 15 ^ systems , , and NR 13 (i)R 18 (0 as well as substituents and/or substituents in the cyclic imides G i3 can be substituted independently by one to three of the same or different groups, selected from halogen, cyano, alkyl, especially C -Cg-alkyl, trifluoromethyl, cycloalkyl, especially C3-C -cycloalkyl, aralkyl such as benzyl, aryl such as phenyl, hydroxy, hydroxyalkyl, especially C]_-Cg-hydroxyalkyl, alkoxy, especially Cχ-Cg-alkoxy, C^-Cg-Alkoxy entirely or partially substituted by fluorine, aralkyl such as benzyloxy, aryloxy such as phenoxy, mercapto, alkylthio, especially C^-Cg- alkylthio, arylthio such as phenylthio, sulfo, carboxy, carboxyalkyl, especially C2~C7-carboxyalkyl, carboxyalkenyl, especially C3-C7~carboxyalkenyl, alkoxycarbonyl, especially C2 _ C7-alkoxycarbonyl, aralkyloxycarbonyl such as benzyloxycarbonyl, nitro, amino, a inoalkyl, especially C ] _- Cg-aminoalkyl, mono- or dialkylamino, especially mono-C -Cg- alkylamino or di- (C^-Cg-alkyl) amino and in the case of two adjacent residues on the aromatic ring, methylenedioxy, and whereby alkyl and cycloalkyl residues in the groups G can be substituted by one or two of the same or different groups, selected from hydroxy, carboxy, alkoxycarbonyl, especially C2~C7-alkoxy- carbonyl, aralkyloxycarbonyl such as benzyloxycarbonyl, amino, mono- or dialkylamino, especially mono-C^-Cg- alkylamino and di- (C_-Cg-alkyl) amino . Pursuant to a preferred embodiment according to the invention, the following compound group encompassed by the above defined general formula (I) can be deployed according to the narrower general formula, herein defined with formula (la) , wherein the substituents of the compounds according to this formula (la) 27 R- A — C -N- R< R ' ^ N ( ° ) k i la) have the following meanings: R 1 is hydrogen, fluorine, methyl, trifluoromethyl or hydroxy, R 2 and R 3 are hydrogen, R 4 is hydrogen or hydroxy, k is 0, A is ethylene, propylene or butylene, which can each be optionally substituted by hydroxy or once or twice by fluorine, or 0CH 2 , SCH 2 , or ethenylene and/or vinylene or 1, 3-butadienylene, D is selected from C2-Cg-alkylene or C2~Cg-alkenylene, whereby the double bond can also occur to the ring E, E is selected from pyrrolidine, piperidine, hexahydroazepine or morpholine, G is selected from benzyl, phenethyl, fluoroenylmethyl, anthrylmethyl, diphenylmethyl, fluoroenyl or dihydrodi- benzocycloheptenyl, furylmethyl, thienylmethyl, thiazol- ylmethyl, pyridylmethyl, benzothienylmethyl, quinolyl- methyl, phenylthienylmethyl, phenylpyridylmethyl, di- hydrodibenzoxepinyl, dihydrodibenzothiepinyl; acetyl, pivaloyl, phenylacetyl, diphenylacetyl, di- phenylpropionyl, naphthylacetyl, benzoyl, naphthoyl, 28 anthrylcarbonyl, oxofluoroenylcarbonyl, oxodihydro- anthrylcarbonyl or dioxodihydroanthrylcarbonyl; furoyl, pyridylcarbonyl, chromonylcarbonyl, quinolyl- carbonyl; naphthylaminocarbonyl, dibenzylaminocarbonyl, benzyl- phenylaminocarbonyl, diphenylaminocarbonyl, indolinyl-1- carbonyl, dihydrodibenzazepin-N-carbonyl, tetrahydro- quinolinyl-N-carbonyl, tetrahydrobenzoazepinyl-N-car- bonyl; methanesulfonyl, phenylsulfonyl, p-tosyl, naphthylsulfonyl, quinolinsulfonyl, and diphenylphosphinoyl , whereby aromatic ring systems can be substituted independently from each other by one to three of the same or different substituents from the series halogen, cyano, C]_-Cg- alkyl, trifluoromethyl, C3-Cg-cycloalkyl, phenyl, benzyl, hydroxy, C ] _-Cg-alkoxy, C]_-Cg-alkoxy which can be entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, C ] _-Cg-alkylthio, carboxy, C -Cg-alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, mono-C]_-Cg-alkylamino or di- (C -Cg-alkyl) -amino, whereby two adjacent groups in the ring or ring systems can form an additional ring over a methylenedioxy bridge. In a particularly preferred manner, the above defined cancerostatic agents or tumor inhibitors used according to the invention concern substituted pyridylcarboxamides of the general formula (la) in the form of the following compounds: N- [2- (l-benzylpiperidin-4-yl) -ethyl] -3- (pyridin-3-yl) - pro ionamide ; N- {2- [1- (2-phenylethyl) -piperidin-4-yl] -ethyl} -3- (pyridin-3- yl) -propionamide; N-{2- [1- (4-phenylbutyl) -piperidin-4-yl] -ethyl} -3- (pyridin-3- yl) -propionamide; N- {2- [1- (4-hydroxy-4-phenylbutyl) -piperidin-4-yl] -ethyl} -3- (pyridin-3-yl) -propionamide; N- [2- (l-diphenylmethylpiperidin-4-yl) -ethyl] -3- (pyridin-3- yl) -propionamide, N- [3- (l-diphenylmethylpiperidin-4-yl) -propyl] -3- (pyridin-3- yl) -propionamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3- (pyridin-3- yl) -propionamide; N- [4- (l-benzylpiperidin-4-yl) -butyl] -3- (pyridin-3 -yl) - acrylamide; N- {4- [1- (2-phenylethyl) -piperidin-4-yl] -butyl} -3- (pyridin-3- yl) -acrylamide; N- {4- [1- (4-biphenylylmethyl) -piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -acrylamide; N- {4- [1- (1-naphthylmethyl) -piperidin-4-yl] -butyl} -3- (pyridin- 3-yl) -acrylamide; N- {4- [1- (9-anthrylmethyl) -piperidin-4-yl] -butyl} -3- (pyridin- 3-yl) -acrylamide; N- {4- [1- (cyclohexylphenylmethyl) -piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -acrylamide; N- {4- [1- (10 , ll-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) - piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -acrylamide; N- [2- (l-diphenylmethylpiperidin-4-yl) -ethyl] -3- (pyridin-3- yl) -acrylamide; N- [3- (l-diphenylmethylpiperidin-4-yl) -propyl] -3- (pyridin-3- yl) -acrylamide; N- [5- (l-diphenylmethylpiperidin-4-yl) -pentyl] -3- (pyridin-3 - yl) -acrylamide; N- [6- (l-diphenylmethylpiperidin-4-yl) -hexyl] -3- (pyridin-3 - yl) -acrylamide; N- [4- (l-diphenylmethylpipεridin-4-yl) -butyl] -5- (pyridin-3- yl) -2 , 4-pentadienoic acid amide; N- (4-{l- [to- (4-fluorophenyl) -methyl] -piperidin-4-yl} -butyl) - 3- (pyridin-3-yl) -acrylamide; N- (4- {l- [to- (2-chlorophenyl) -methyl] -piperidin-4-yl} -butyl) - 3- (pyridin-3-yl) -acrylamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3- (2-fluoro- pyridin-3-yl) -acrylamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3- (6-fluoro- pyridin-3-yl) -acrylamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3- (pyridin-3- yl) -acrylamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3- (pyridin-3- yl) -acrylamide»dihydrochloride or N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3- (pyridin-3- yl) -acrylamide«methanesulfonate; A further preferred group in this series are presented in the following compounds N- [4- (l-acetyl-piperidin-4-yl) -butyl] -3- (pyridin-3-yl) - propionamide ; N- [4- (l-benzoyl-piperidin-4-yl) -butyl] -3- (pyridin-3-yl) - propionamide ; N- [4- (l-diphenylacetyl-piperidin-4-yl) -butyl] -3- (pyridin-3- yl) -propionamide; N- {4- [1- (9-oxo-9H-fluoroen-4-carbonyl) -piperidin-4-yl] - butyl} -3- (pyridin-3 -yl) -propionamide; N- [4- (l-methylsulfonyl-piperidin-4-yl) -butyl] -3- (pyridin-3- yl) -propionamide; N-{4- [1- (2-naphthyl-sulfonyl) -piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -propionamide,- N- [4- (l-benzyl-piperidin-4-yl) -butyl] -3- (pyridin-3 -yl) - propionamide ; N- (4- {l- [to- (2-chlorophenyl) -methyl] -piperidin-4-yl} -butyl) - 3- (pyridin-3 -yl) -propionamide; N-{4- [1- (phenylpyridin-3-yl-methyl) -piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -propionamide; N- {4- [1- (9H-fluoroen-9-yl) -piperidin-4-yl] -butyl} -3- (pyridin- 3-yl) -propionamide; N- {4- [1- (6 , 11-dihydrodibenzo [b, e] oxepin-11-yl) -piperidin-4- yl] -butyl} -3- (pyridin-3 -yl) -propionamide; 31 N-{4- [1- (1-naphthylamino-carbonyl) -piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -propionamide; N- [4- (l-diphenylamino-carbonyl-piperidin-4-yl) -butyl] -3- (pyridin-3-yl) -propionamide; N- {4- [1- (10 , 11-dihydro-dibenzo [b, f] azepin-5-yl-carbonyl) - piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -propionamide; N- [4- (l-Diphenylphosphinoyl-piperidin-4-yl) -butyl] -3- (pyridin-3-yl) -propionamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3- (2-fluoro- pyridin-3-yl) -propionamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3- (5-fluoro- pyridin-3-yl) -propionamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -2-fluoro-3- (pyridin-3-yl) -propionamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -2, 2-difluoro-3- (pyridin-3-yl) -propionamide; N- [5- (l-diphenylmethylpiperidin-4-yl) -pentyl] -3- (pyridin-3- yl) -propionamide; N- [6- (l-diphenylmethylpiperidin-4-yl) -hexyl] -3- (pyridin-3- yl) -propionamide; N- [2- (l-diphenylmethylpiperidin-4-yl) -ethyl] -5- (pyridin-3- yl) -pentanoic acid amide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -5- (pyridin-3- yl) -pentanoic acid amide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -N-hydroxy-3- (pyridin-3-yl) -propionamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -2-hydroxy-3- (pyridin-3-yl) -propionamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3-hydroxy-3- (pyridin-3-yl) -propionamide and N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3- (pyridin-3- yl) -propionamide; Furthermore, the following group of compounds are also preferred in this series: N- [4- (l-methylsulfonylpiperidin-4-yl) -butyl] -3- (pyridin-3- yl) -acrylamide; 32 N-{4- [1- (2-naphthylsulfonyl) -piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -acrylamide; N-{4- [1- (2-naphthylsulfonyl) -piperidin-4-yl] -butyl} -5- (pyridin-3-yl) -2, 4-pentadienoic acid amide; N-{4- [1- (1-naphthylaminocarbonyl) -piperidin-4-yl] -butyl} -3 - (pyridin-3-yl) -acrylamide; N- [4- (l-diphenylaminocarbonylpiperidin-4-yl) -butyl] -3- (pyridin-3-yl) -acrylamide; N- [4- (l-diphenylaminocarbonyl-piperidin-4-yl) -butyl] -5- (pyridin-3-yl) -2 , 4-pentadienoic acid amide; N- {4- [1- (10, 11-dihydrodibenzo [b, f] azepin-5-yl-carbonyl) - piperidin-4-yl] -butyl} -3- (pyridin-3 -yl) -acrylamide; N- [4- (l-Diphenylphosphinoyl-piperidin-4-yl) -butyl] -3- (pyridin-3-yl) -acrylamide; N- [4- (l-acetylpiperidin-4-yl) -butyl] -3- (pyridin-3-yl) - acrylamide ; N- [4- (l-diphenylacetylpiperidin-4-yl) -butyl] -3- (pyridin-3 - yl) -acrylamide; N- {4- [1- (3 , 3-diphenylpropionyl) -piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -acrylamide; N- [4- (l-benzoylpiperidin-4-yl) -butyl] -3- (pyridin-3 -yl) - acrylamide; N- [4- (l-benzoylpiperidin-4-yl) -butyl] -5- (pyridin-3 -yl) -2 , 4- pentadienoic acid amide; N-{4- [1- (9-oxo-9H-fluoren-4-yl-carbonyl) -piperidin-4-yl] - butyl} -3- (pyridin-3-yl) -acrylamide; N- {4- [1- (phenylpyridin-3-yl-methyl) -piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -acrylamide; N-{4- [1- (phenylpyridin-4-yl-methyl) -piperidin-4-yl] -butyl} -3 - (pyridin-3-yl) -acrylamide; N- {4- [1- (6, 11-dihydrodibenzo [b, e] oxepin-11-yl) -piperidin-4- yl] -butyl} -3- (pyridin-3 -yl) -acrylamide; N-{4- [1- (6, 11-dihydrodibenzo [b, e] thiepin-11-yl) -piperidin-4- yl] -butyl} -3- (pyridin-3 -yl) -acrylamide; N- [7- (l-diphenylmethylpiperidin-4-yl) -heptyl] -3- (pyridin-3- yl) -acrylamide; N- [8- (l-diphenylmethylpiperidin-4-yl) -octyl] -3- (pyridin-3- yl) -acrylamide; 33 N- [3- (l-diphenylmethylpiperidin-4-yloxy) -propyl] -3- (pyridin- 3-yl) -acrylamide; N- [3- (l-benzylpiperidin-4-yloxy) -propyl] -3- (pyridin-3 -yl) - acrylamide; N- [2- (l-diphenylmethylpiperidin-4-yl) -ethyl] -5- (pyridin-3- yl) -2 , 4-pentadienoic acid amide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -5- (pyridin-3- yl) -2 , 4-pentadienoic acid amide; N- [5- (l-diphenylmethylpiperidin-4-yl) -pentyl] -5- (pyridin-3- yl)-2,4- pentadienoic acid amide; or N- [6- (l-diphenylmethylpiperidin-4-yl) -hexyl] -5- (pyridin-3 - yl)-2,4- pentadienoic acid amide; A further preferred embodiment according to the invention is in the use of the following compound group, also falling under the above general formula (I), according to the narrower general formula, herein defined with formula (la) and which is described above. This compound group relates to compounds of the general formula (la), wherein R! is selected from hydrogen, fluorine, methyl, trifluoromethyl, ethylthio; R 2 ' R 3 and R^ are each hydrogen; k is 0, A is selected from ethylene, propylene or butylene, which are each optionally substituted by hydroxy or one or two fluorine atoms; or OCH 2 , SCH 2 ; ethenylene or 1, 3-butadienylene; D is selected from C2~cg-alkylene, is optionally substituted by hydroxy; C4~Cg-alkenylene; C4-Cg-alkinylene; or 34 C2 ~ Cg-alkylene, C4~Cg-alkenylene or C4~Cg-alkinylene, wherein one or two methylene units are isosterically replaced by 0, NH, CO or SO2 • E is selected from piperazine or hexahydro-1, 4-diazepine; G is selected from phenyl, benzyl, phenethyl, diphenylmethyl, naphthyl, tetrahydronaphthyl, naphthylmethyl, fluoroenyl, fluoroenylmethyl, anthrylmethyl, dihydrodibenzocycloheptenyl ; furylmethyl, thienylmethyl, thiazolylmethyl, pyridyl- methyl, benzothienylmethyl, quinolylmethyl, phenylthi- enylmethyl, phenylpyridylmethyl, benzocyclohepta- pyridinyl, dihydrobenzocycloheptapyridinyl, dihydrodibenzooxepinyl, dihydrodibenzothiepinyl, dihydrodibenzoazepinyl, dihydrobenzopyridodiazepinyl; formyl, acetyl, pivaloyl, phenylacetyl, diphenylacetyl, diphenylpropionyl, naphthylacetyl, benzoyl, naphthoyl, oxofluoroenylcarbonyl, oxodihydroanthrylcarbonyl, dioxo- dihydroanthrylcarbonyl, furoyl, pyridylacetyl, pyridyl- carbonyl, chromonylcarbonyl, quinolylcarbonyl; phenylylaminocarbonyl, naphthylaminocarbonyl, tetra- hydronaphthylaminocarbonyl, dibenzylaminocarbonyl, benzylphenylaminocarbonyl , diphenylaminocarbonyl , indolinyl-N-carbonyl, isoindolin-N-carbonyl, tetra- hydroquinolinyl-N-carbonyl , carbazolyl-N-carbonyl , tetrahydrobenzoazepinyl-N-carbonyl , dihydrodibenzo- azepin-N-carbonyl , dihydrobenzopyridoazepinyl-N-car- bonyl, oxodihydrobenzopyridoazepinyl-N-carbonyl; methanesulfonyl, tolylsulfonyl, naphthylsulfonyl, quinolinsulfonyl and diphenylphosphinoyl, whereby aromatic ring systems can be substituted independently from each other by one to three of the same or different groups that are selected from halogen, cyano, Cχ-Cg-Alkyl, trifluoromethyl, C3-C8-cyclo- alkyl, phenyl, benzyl, hydroxy, C ] _-Cg-hydroxyalkyl, C_-Cg- alkoxy, Cχ-Cg-Alkoxy entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, C ] _-Cg-alkylthio, carboxy, C2~C7-carboxyalkyl, C2~C7-carboxyalkenyl, C2-C7- alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, mono-C_-Cg- alkylamino, Di- (C_-Cg-alkyl) -amino and, in the case of two adjacent residues on an aromatic ring, methylenedioxy, and whereby alkyl, alkenyl and cycloalkyl residues in the group G can be substituted by one or two of the same or different groups that are selected from hydroxy, carboxy, C2 _ C7-alkoxycarbonyl, benzyloxycarbonyl, amino, mono-C]_-Cg-alkylamino or di- (C^-Cg-alkyl) -amino . From the above defined group, the following piperazinyl substituted compounds according to the general formula (I) are preferably used according to the invention: N- [4- (4-diphenylmethylpiperazin-l-yl) -3 -hydroxy-butyl] -3- pyridin-3 -yl-acrylamide; N- [3- (4-diphenylmethylpiperazin-l- yl) -propoxy] -3 -pyridin-3 -yl-acrylamide; N- [4- (4- diphenylmethylpiperazin-1-yl) -4-oxo-butyl] -3 -pyridin-3 -yl- acrylamide; N- [3- (4-diphenylmethylpiperazin-l-sulfonyl) - propyl] -3 -pyridin-3 -yl-acrylamide; N- {2- [2- (4- diphenylmethylpiperazin-1-yl) -ethoxy] -ethyl} -3 -pyridin-3 -yl- acrylamide; N- (4-{4- [to- (4-fluorophenyl) -methyl] -piperazin-1- yl}-but-2-inyl) -3 -pyridin-3 -yl-acrylamide; N- {4- [4- (4- carboxyphenyl-phenylmethyl) -piperazin-1-yl] -butyl} -3-pyridin- 3 -yl-acrylamide; N- (4- {4- [ (4-aminophenyl) -phenylmethyl] - piperazin-1-yl} -butyl) -3 -pyridin-3 -yl-acrylamide; N-{4- [4- (9H-fluoroen-9-yl) -piperazin-1-yl] -butyl} -2- (pyridin-3- yloxy) -acetamide; N-{5- [4- (9H-fluoroen-9-yl) -piperazin-1-yl] - 36 pentyl} -3 -pyridin-3 -yl-acrylamide; N- {6- [4- (9H-fluoroen-9- yl) -piperazin-1-yl] -hexyl} -3 -pyridin-3 -yl-acrylamide ; 3-pyridin-3-yl-N-{4- [4- (1,2, 3, 4-tetrahydronaphthalin-l-yl) - piperazin-1-yl] -butyl} -acrylamide; 3- pyridin-3 -yl-N- {4- [4- (5,6,7, 8-tetrahydronaphthalin-l-yl) -piperazin-1-yl] -butyl} - acrylamide; N- {4- [4- (naphthalin-1-yl) -piperazin-1-yl] -butyl} - 3 -pyridin-3 -yl-acrylamide; N- [4- (4-biphenyl-2-yl-piperazin-l- yl) -butyl] -3 -pyridin-3 -yl-propionamide; N- [5- (4-biphenyl-2- yl-piperazin-1-yl) -pentyl] -3 -pyridin-3 -yl-acrylamide; N- [6- (4-biphenyl-2-yl-piperazin-l-yl) -hexyl] -3-pyridin-3-yl- acrylamide; N- [4- (4-biphenyl-2-yl-piperazin-l-ly) -butyl] -2- (pyridin-3-yloxy) -acetamide; N- [4- (4-biphenyl-2-yl-piperazin- 1-yl) -butyl] -5- (pyridin-3 -yl) -penta-2, 4-dienoic acid amide; N-{4- [4- (10, ll-dihydro-5H-dibenzo [a,d] cyclohepten-5-yl) - piperazin-1-yl] -butyl} -3 -pyridin-3 -yl-propionamide; N-{5- [4- (10 , ll-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -piperazin-1- yl] -pentyl} -3 -pyridin-3 -yl-acrylamide; N-{6-[4-(10,ll- dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -piperazin-1-yl] - hexyl} -3 -pyridin-3 -yl-acrylamide; N-{4- [4- (10, ll-dihydro-5H- dibenzo [a, d] cyclohepten-5-yl) -piperazin-1-yl] -butyl} -5- (pyridin-3-yl) -penta-2, 4-dienoic acid amide; N- {4- [4- (6, 11- dihydro-dibenzo [b, e] oxepin-11-yl) -piperazin-1-yl] -butyl-3- pyridin-3 -yl-propionamide; N- {2- [4- (6, 11-dihydrodibenzo [b, e] thiepin-11-yl) -piperazin-1-yl] -ethyl} -3-pyridin- 3 -yl-acrylamide; N- [4- (4-diphenylacetylpiperazin-l-yl) - butyl] -3 -pyridin-3 -yl-acrylamide; N- [4- (4-benzoylpiperazin-l- yl) -butyl] -3 -pyridin-3 -yl-acrylamide; N-{4- [4- (2- aminobenzoyl) -piperazin-1-yl] -butyl} -3-pyridin-3-yl- acrylamide; N-{4- [4- (4-carboxybenzoyl) -piperazin-1-yl] - butyl} -3 -pyridin-3 -yl-acrylamide; N-{4- [4- (biphenyl-2- carbonyl) -piperazin-1-yl] -butyl} -3 -pyridin-3 -yl-acrylamide ; N-{4- [4- (9-oxo-9H-fluoroen-4-carbonyl) -piperazin-1-yl] - butyl} -3 -pyridin-3 -yl-acrylamide; N-{4- [4- (furan-2-carbonyl) - piperazin-1-yl] -butyl} -3-pyridin-3-yl-acrylamide; N- {4- [4- (naphthalin-1-yl-aminocarbonyl) -piperazin-1-yl] -butyl} -3- pyridin-3 -yl-propionamide; N-{4- [4- (diphenylaminocarbonyl) - piperazin-1-yl] -butyl} -3 -pyridin-3 -yl-acrylamide; N-{4- [4- (naphthalin-2-sulfonyl) -piperazin-1-yl] -butyl} -3 -pyridin-3- yl-acrylamide; N- [4- (4-diphenylphosphinonyl-piperazin-l-yl) - butyl] -3-pyridin-3-yl-acrylamide; N- [4- (4-biphenyl-2-yl- piperazin-1-yl) -butyl] -3 -pyridin-3 -yl-acrylamide ; N- {4- [4- (9H-fluoroen-9-yl) -piperazin-1-yl] -butyl} -3-pyridin- 3 -yl-acrylamide as well as N- {4- [4- (10 , ll-dihydro-5H- dibenzo [a, d] cyclohepten-5-yl) -piperazin-1-yl] -butyl} -3- pyridin-3 -y1-acrylamide ; Furthermore, according to the invention, the use of the following group of compounds according to the general formula (I) described above represent a further preferred embodiment. In these compounds, the substituents have the following meanings : R! is selected from hydrogen, fluorine, methyl, trifluoromethyl, ethylthio; R 2 , R 3 and R 4 are each hydrogen; k is 0, A is selected from ethylene, propylene or butylene, optionally substituted by hydroxy or one or two fluorine atoms, or OCH2 or SCH 2 ; ethenylene or 1, 3-butadienylene; D is selected from C4~Cg-alkylene, optionally substituted by hydroxy, C4- Cg-alkenylene, C4-Cg-alkinylene or C4~Cg-alkylene, C4~Cg-alkenylene or C4-Cg-alkinylene, wherein one or two methylene units are isosterically replaced by 0, NH, CO or SO2; E is piperidine; G is selected from diphenylmethyl , diphenylhydroxymethyl, diphenylmethylene, naphthyl, tetrahydronaphthyl, tetrahydronaphthylidene, fluoroenyl, fluoroenylidene, 38 tetrahydrobenzocycloheptenyl or tetrahydrobenzocycloheptenylidene, dihydrodibenzo- cycloheptenyl or dihydrodibenzocycloheptenylidene; mixed diphenyl; phenylthienylmethyl, phenylthienylmethylene, phenylpyridylmethyl , phenylpyridylmethylene, tetrahydroquinolinyl, tetrahydroisoquinolinyl, benzocycloheptapyridinyl, benzocycloheptapyridmylidene, dihydrobenzocycloheptapyridinyl, dihydrobenzocycloheptapyridinylidene, dihydrodibenzooxepinyl, dihydrodibenzooxepinylidene, dihydrodibenzothiepinyl, dihydrodibenzothiepinylidene, dihydrobenzothienothiepinyl or dihydrobenzothienothi- epinylidene; indolyl, oxobenzoi idazolyl, oxobenzothiazolyl, benzo- isothiazolyl or benzotriazolyl; dibenzylaminocarbonyl, diphenylaminocarbonyl, indolinyl- N-carbonyl, isoindolinyl-N-carbonyl, tetrahydroquinolinyl-N-carbonyl, tetrahydrobenzoazepinyl-N-carbonyl, carbazolyl-N- carbonyl, dihydrodibenzoazepinyl-N-carbonyl or oxodihydrobenzopyridodiazepinyl-N-carbonyl; diphenylmethylamino, diphenylmethyl-methylamino, dibenzyla ino, benzylphenylamino or triphenylmethyl- amino; acetylamino, pivaloylamino, phenylacetylamino, diphenyl- acetylamino, diphenylpropionylamino, naphthylacetyl- amino, benzoylamino, benzoylmethylammo, naphthoylamino or oxofluoroenylcarbonylamino; furoylamino, pyridylacetylamino or pyridylcarbonyl- amino; benzylaminocarbonylamino, naphthylmethylaminocarbonyl- amino, indanylaminocarbonylamino, tetrahydronaphthyl- aminocarbonyl, dibenzylaminocarbonylamino, phenylyl- aminocarbonylamino, naphthylaminocarbonylamino, benzyl- 39 phenylaminocarbonylamino or diphenylaminocarbonyl-amino; indolinyl-N-carbonylamino, isoindolinyl-N-carbonylamino, tetrahydroquinolinyl-N-carbonylamino , tetrahydrobenzoaz- epinyl-N-carbonylamino, carbazolyl-N-carbonylamino, di- hydrophenanthridinyl-N-carbonylamino, dihydrodibenzo- azepin-N-carbonylamino, dihydrobenzopyridoazepinyl-N- carbonylamino or oxodihydrobenzopyridodiazepinyl-N- carbonylamino ; methanesulfonylamino, tolylsulfonylamino, naphthylsulfonylamino or diphenylphosphinoylamino; diphenylmethyloxy or diphenylphosphinoyloxy, whereby aromatic ring systems can be substituted independently from each other by one to three of the same or different groups, selected from halogen, cyano, C]_-Cg-alkyl, trifluoromethyl, C3-C8~cyclo- alkyl, phenyl, benzyl, hydroxy, C_-Cg-hydroxyalkyl, Cχ-Cg- alkoxy, Cχ-Cg-alkoxy entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, C^-Cg-alkylthio, carboxy, C2~C7-carboxyalkyl, C2~C7-carboxyalkenyl, C2-C7- alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, mono-Cχ-Cg- alkyl-amino, di- (Cχ-Cg-alkyl) -amino and, in the case of two adjacent residues in an aromatic ring, methylenedioxy, and whereby alkyl, alkenyl and cycloalkyl residues in the group G can be substituted once or twice of the same or different group, selected from hydroxy, carboxy, C2-C7~alkoxycarbonyl, benzyloxycarbonyl, amino, mono-Cχ-Cg-alkylamino and di- (C^-Cg-alkyl) amino; as well as the salts, isomers and tautomers of the above defined compounds as well as, optionally, their mixtures. Among this group, the following piperidyl-substituted derivatives according to the general formula (I) are preferably used according to the invention: N- [4- (4-phenylpiperidin-l-yl) -butyl] -3-pyridin-3-yl- acrylamide; N- {4- [4- (lH-indol-3-yl) -piperidin-1-yl] -butyl} -3- pyridin-3 -yl-acrylamide; N- {4- [4- (2-oxo-2 , 3- dihydrobenzimidazol-1-yl) -piperidin-1-yl] -butyl} -3-pyridin-3- yl-acrylamide; N- [4- (4-benzotriazol-l-yl-piperidin-l-yl) - butyl] -3 -pyridin-3 -yl-acrylamide; N-{4- [4- (hydroxy- diphenylmethyl) -piperidin-1-yl] -butyl} -2- (pyridin-3 -yloxy) - acetamide; N- [4- (4, 4-diphenylpiperidin-l-yl) -butyl] -3- pyridin-3 -yl-acrylamide; N- {4- [4- (6, 11- dihydrodibenzo [b, e] thiepin-11-yliden) -piperidin-1-yl] -butyl} - 3 -pyridin-3 -ylpropionamide»dihydrochloride/ semi-isopropanol; N- {4- [4- (6, 11-dihydrodibenzo [b, e] thiepin-11-yliden) - piperidin-1-yl] -butyl} -5-pyridin-3 -yl-pentanamide; N-{4- [4- (4, 9-dihydro-thieno [2, 3-b] -benzo [e] thiepin-4-yliden) - piperidin-1-yl] -butyl} -3 -pyridin-3 -yl-propionamide; N-{4- [4- (4, 9-dihydro-thieno [2, 3-b] -benzo [e] thiepin-4-yliden) - piperidin-1-yl] -butyl} -3 -pyridin-3 -yl-acrylamide; N- [4- (4- diphenylphosphinoyloxypiperidin-1-yl) -butyl] -3 -pyridin-3 -yl- acrylamide as well as N- [4- (1, 4-dioxa-8-azaspiro [4.5] dec-8- yl) -butyl] -3 -pyridin-3 -yl-acrylamide ; A further preferred embodiment according to the invention relates to a group of compounds according to the general formula, herein defined as formula (lb) 41 (lb) which also falls under the scope of the above given formula (I), wherein the defined substituents have the following meanings : R^ is selected from hydrogen, fluorine, methyl, trifluoromethyl, ethylthio; R 2 and R 4 are hydrogen; k is 0, A is selected from ethylene or butylene, optionally substituted by hydroxy or one or two fluorine atoms, or OCH 2 , SCH , ethenylene or 1, 3-butadienylene; is selected from C4-Cg-alkylene, optionally substituted by hydroxy; C4-Cg-alkenylene; C4-Cg-alkinylene; or C4~Cg-alkylene, C4~Cg-alkenylene or C4~Cg-alkinylene wherein one or two methylene units are isosterically replaced by 0, NH or CO; represent a single bond, 42 G is selected from monocyclic imides such as succinimide, maleinimide, glu- tarimide, imidazolidindione, imidazolidintrione, thiazolidindione, oxazolidindione, piperazin-2, 6-dione, hexahydrodiazepin-2, 7-dione; anellated bicyclic imides such as phthalimide, homo- phthalimide, pyridin-2, 3-dicarboximide, pyridin-3, 4- dicarboximide, isatoic acid imide; anellated tricyclic imides such as naphthalin-1, 2-di- carboximide, naphthalin-2, 3-dicarboximide, 1,8- naphthalimide, diphenic acid imide; anellated tetracyclic imides such as 7, 8-dihydroace- naphthen-2 ( 6H) -on-1, 8a-dicarboximide, anthracen-2, 3- dicarboximide, anthracen-1, 9-dicarboximide, phenanthren- 9, 10-dicarboximide, bridged polycyclic imides such as bicyclo [2.2.1] -hept-5- en-2, 3-dicarboximide, 7-oxa-bicyclo [2.2.1] -hept-5-en- 2, 3-dicarboximide, benzobicyclo [2.2.2] -octan-2, 3- dicarboximide, dibenzobicyclo [2.2.2] -octan-2, 3- dicarboximide; and spirocyclic imides such as spiro [dioxoimidazolidin- indane] , spiro [dioxoimidazolidin-piperidine] , spiro [di- oxoimidazolidin-oxoindoline] and spiro [dioxoimidazol- idin-tetrahydronaphthaline] , whereby these cyclic imides can be substituted by one to four of the same or different groups, selected independently from each other from halogen, C ] _-C4-alkyl, trifluoromethyl, hydroxy, hydroxymethyl, methoxy, ethoxy, tert-butoxy, trifluormethoxy, benzyloxy, phenoxy, phenylthio, pyridylthio, phenylsulfonyl, sulfo, carboxy, C2~C7-carboxyalkyl, C2~C7-carboxyalkenyl, C2~ 43 C7-alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, aminomethyl, dimethylamino, diethylamino, phenylamino, pyridylamino ; benzyl, benzylidene, phenylethyl, naphthylmethyl, diphenylmethyl, diphenylmethylene, triphenylmethyl, phenyl, naphthyl ; pyrrolidinyl, piperidinyl, morpholinyl, thiomorpholinyl, piperazinyl, hexahydroazepinyl, hexahydrodiazepinyl; furyl, furylmethyl, thienyl, thienylmethyl, thiazolyl, thiazolylmethyl, pyridyl, pyridylmethyl; benzofuryl, benzothienyl, indolyl, indolylmethyl, oxodihydro- indolyl, benzoimidazolyl, benzoimidazolylmethyl, oxodihydro- benzoimidazolyl, benzooxazolyl, oxodihydrobenzooxazolyl, benzothiazolyl, oxodihydrobenzothiazolyl, quinolinyl, quinolinylmethyl, oxodihydroquinolinyl, isoquinolinyl, oxodihydroisoquinolinyl, and whereby aryl and heteroaryl residues as substituents of the cyclic imides can be substituted themselves by one to three of the same or different groups selected from halogen, cyano, C -Cg-alkyl, trifluoromethyl, C3-Cg-cyclo- alkyl, benzyl, phenyl, hydroxy, C -Cg-hydroxyalkyl, C]_-Cg- alkoxy, C^-Cg-alkoxy entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, C -Cg-alkylthio, phenylthio, carboxy, C2~C7-carboxyalkyl, C2-C7- carboxyalkenyl, C2-C7~alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, C -Cg-aminoalkyl, mono-Cχ-Cg-alkylamino, di- (Cχ-Cg-alkyl) amino and, in the case of two adjacent residues, methylenedioxy . Among this compound group the following imide substituted compounds of the general formula (I) as preferred in the use according to the invention: 44 N- [4- (2, 5-dioxo-3,4-diphenyl-2, 5-dihydropyrrol-l-yl) -butyl] - 3 -pyridin-3 -yl-acrylamide; N- [4- (2 , 6-dioxo-4-phenylpiperidin- 1-yl) -butyl] -3 -pyridin-3 -yl-acrylamide; N- [4- (1, 3-dioxo- 4,5,6, 7-tetraphenyl-l, 3-dihydro-isoindol-2-yl) -butyl] -3- pyridin-3 -yl-acrylamide; N- [4- (3-benzyl-2, 4, 5-trioxo- imidazolidin-1-yl) -butyl] -3 -pyridin-3 -yl-acrylamide; N- [4- (1,3, 10-trioxo-l, 4, 5, 6, 10, lOa-hexahydro-acenaphtho- [1, 8a- c]pyrrol-2-yl) -butyl] -3 -pyridin-3 -yl-acrylamide; N- [4- (2, 5- dioxo-4, 4-diphenylimidazolidin-l-yl) -butyl-3 -pyridin-3 -yl- acrylamide; N- [4- (2, 5-dioxo-3-phenyl-2, 5-dihydropyrrol-l-yl) - butyl] -3 -pyridin-3 -yl-acrylamide; N- [3- (2, 5-dioxo-3, 4- diphenyl-2 , 5-dihydro-pyrrol-1-yl) -propyl] -3-pyridin-3-yl- acrylamide; N- [4- (3-pyridin-3-yl-acroylamino) -butyl] -2,3:5,6- dibenzobicyclo [2.2.2] octan-7, 8-dicarboximide; N- [4- (5- benzyliden-2 , 4-dioxothiazolidin-3-yl) -butyl] -3-pyridin-3-yl- acrylamide; N- [4- (4-benzyl-2, 6-dioxopiperazin-l-yl) -butyl] -3- pyridin-3 -yl-acrylamide; N- [6- (2, 5-dioxo-3, 4 -diphenyl-2 , 5- dihydropyrrol-1-yl) -hexyl] -3 -pyridin-3 -yl-acrylamide; N- [4- (2 , 5-dioxo-3 , 4-diphenyl-2 , 5-dihydropyrrol-l-yl) -butyl] -3- pyridin-3 -yl-propionamide; N- [4- (1, 3-dioxo-l, 3-dihydro- isoindol-2-yl) -butyl] -3 -pyridin-3 -yl-acrylamide; N- [4- (1,3- dioxo-lH, 3H-benzo [de] isoquinolin-2-yl) -butyl] -3- (1- oxidopyridin-3-yl) -acrylamide; N- [6- (1, 3-dioxo-lH, 3H- benzo[de] isoquinolin-2-yl) -hexyl] -3 -pyridin-3 -yl-acrylamide ; N- [2- (1, 3-dioxo-lH, 3H-benzo[de] isoquinolin-2-yl) -ethyl] -3- pyridin-3 -yl-acrylamide as well as N- [4- (1, 3-dioxo-lH, 3H- benzo [de] isoquinolin-2-yl) -butyl] -3-pyridin-3-yl-acrylamide; Furthermore, a group of compounds according to general formula, herein defined as general for ual (Ic), which also falls under the above broader general formula (I), used according to the invention is: 45 R2 R3 -N- R 1 R4 N (0) k (Ic) with the following substituent meanings being preferred: R is selected from hydrogen, fluorine, methyl, trifluoromethyl, ethylthio; R 2 , R 3 and R 4 are hydrogen; k is 0, A is selected from ethylene or butylene, optionally substituted by hydroxy or one or two fluorine atoms, or OCH 2 , SCH 2 ; ethenylene or 1, 3-butadienylene; D is selected from C3-C8 _ alkylene, optionally substituted by hydroxy or phenyl; C3~C8-alkenylene, optionally substituted by phenyl; C3-C8-alkinylene; or C3-C8~alkylene, C3~Cg-alkenylene or C3-C8~ lkinylene in which one or two methylene units are isosterically replaced by 0, NH or CO; E is a single or double bond; G is selected from cyclopentylphenylmethylene, cyclohexylphenylmethyl, cyclohexylhydroxyphenylmethyl, diphenylmethyl, diphenyl- hydroxymethyl, diphenylmethylene, diphenylethyl, diphenylhydroxyethyl, diphenylethylene, triphenylmethyl, triphenylethyl, triphenylhydroxyethyl, triphenylethylene, naphthylmethylene, naphthyl, tetrahydronaphthyl , hydroxytetrahydronaphthyl, 46 tetrahydronaphthylidene, fluoroenyl, hydroxyfluoroenyl, fluoroenylidene, tetrahydrobenzocycloheptenyl, hydroxytetrahydrobenzocycloheptenyl , tetrahydrobenzo- cycloheptanyl , dihydrodibenzocycloheptenyl , hydroxydihydrodibenzocycloheptenyl , dihydrodibenzocycloheptenylidene; phenylthienylmethyl , phenylthienylhydroxymethyl , phenylthienylmethylene, dithienylmethyl, dithienylhydroxymethyl, dithienylmethylene, phenylfurylmethyl, phenylfurylhydroxymethy1, phenylfurylmethylene, phenylpyridylmethyl, phenylpyridylhydroxymethyl, phenylpyridylmethylene; tetrahydroquinolinyl, tetrahydroisoquinolinyl, benzocycloheptapyridinyl, benzocycloheptapyridinylidene, dihydrobenzocycloheptapyridinyl, dihydrobenzocycloheptapyridinylidene, dihydrodibenzooxepinyl, dihydrodibenzooxepinylidene, dihydrodibenzothiepinyl , dihydrodibenzothiepinylidene ; phenylpyrrolyl, diphenylpyrrolyl, phenylthienyl, diphenylthienyl, phenylpyrazolyl, diphenylpyrazolyl, phenylimidazolyl, diphenylimidazolyl, phenylpyridyl, diphenylpyridyl, indolyl, oxoindolinyl, benzoimidazolyl, oxobenzoimidazolyl, benzothiazolyl, oxobenzothiazolyl, benzoisothiazolyl, benzooxazolyl, oxobenzooxazolyl, benzotriazolyl; diphenylmethylamino, diphenylmethyl-methylamino, dibenzylamino, benzylphenylammo, cyclohexylphenylammo, triphenylmethylammo, biphenylylammo, diphenylamino; N- indolinyl, N-isoindolinyl, N-tetrahydroquinolinyl, N- tetrahydrobenzazepinyl, N-phenyltetrahydrobenzoazepinyl, N-l, l-dioxo-l-thia-2-aza-acenaphthenyl, N-1H, 3H- benzo [de] -isoquinolinyl, N-dihydrodibenzoazepinyl; diphenylmethyloxy, diphenylmethylthio; 47 diphenylacetylamino, diphenylacetylphenylamino, diphenylpropionylamino, diphenylaeryloylamino, naphthylacetylamino, furoylacrylamino, benzoylamino, naphthoylamino, oxofluoroenylcarbonylamino, furoylamino; diphenylmethyla inocarbonylamino, dibenzylaminocarbonyl- amino, naphthylmethylaminocarbonylamino, dibenzylamino- carbonylamino, biphenylylaminocarbonylamino, naphthyl- aminocarbonylamino, benzylphenylaminocarbonylamino, diphenylaminocarbonylamino ; diphenylaminocarbonylphenyl- amino; diphenylfurylaminocarbonylamino, indolinyl-N- carbonylamino, isoindolinyl-N-carbonylamino, 1H, 3H- benzo [de] isoquinolinyl-N-carbonylamino, tetrahydro- benzoazepinyl-N-carbonylamino, phenyltetrahydrobenzo- azepinyl-N-carbonylamino, dihydrodibenzoazepin-N- carbonylamino , dihydrobenzopyridoazepinyl-N- carbonylamino ; tolylsulfonylamino, naphthylsulfonylamino, diphenylphos- phinoylamino and diphenylphosphinoyloxy, and whereby aromatic ring systems in G can be substituted independently from each other by one to three of the same or different groups selected from halogen, cyano, Cχ-Cg-Alkyl, trifluoromethyl, C3-C8~cyclo- alkyl, benzyl, phenyl, hydroxy, C_-Cg-hydroxyalkyl, C ] _-Cg- alkoxy, C ] _-Cg-alkoxy entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, C]_-Cg-alkylthio, phenylthio, sulfo, carboxy, C2~C7-carboxyalkyl, C3-C7- carboxy-alkenyl, C2-C7-alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, C^-Cg-aminoalkyl, mono-Ci-Cg-alkylamino, di- (Cχ-Cg-alkyl) amino and, for two adjacent residues in an aromatic ring, methylenedioxy, and 48 whereby alkyl and cycloalkyl residues in the group G can be substituted by one or two of the same or different groups, selected from hydroxy, carboxy, C2 _ C7-alkoxycarbonyl, benzyloxycarbonyl, amino, mono-Cχ-Cg-alkylamino and di- (C -Cg-alkyl) amino . Among the above defined compound group, the following derivatives represent particularly preferred compounds used according to the invention: N- [8, 8-to- (4 -fluorophenyl) -octyl] -3 -pyridin-3 -yl- acrylamide»hydrochloride; N- [6- (3, 3-diphenylureido) -hexyl] -3- pyridin-3 -yl-acrylamide; N- [4- (1-phenyl-l, 2,4,5- tetrahydrobenzo [d] azepin-3-yl) -butyl] -3 -pyridin-3 -yl- acrylamide; N- (8, 8-diphenyloctyl) -3 -pyridin-3 -yl-acrylamide ; N- (8 -hydroxy-8, 8-diphenyloctyl) -3 -pyridin-3 -yl-acrylamide; N- [4- (3 , 3-diphenylureido) -butyl] -3-pyridin-3-yl-acrylamide; N- [4- (1H, 3H-benzo [de] isoquinolin-2-yl) -butyl] -3-pyridin-3-yl- acrylamide; N- [6- (10, 11-dihydro-dibenzo [b, f] azepin-5-yl- carbonyl-amino) -hexyl] -3 -pyridin-3 -yl-acrylamide; 3-pyridin- 3-yl-N- [6- (tosylamino) -hexyl] -acrylamide; N- [4- (1, 1-dioxo-l- thia-2-aza-acenaphthylen-2-yl) -butyl] -3-pyridin-3-yl- acrylamide; N- (6-hydroxy-6, 6-diphenylhexyl) -3-pyridin-3-yl- acrylamide; N- (6, 6-diphenyl-hex-5-enyl) -3-pyridin-3-yl- acrylamide; N- [4- (4, 5-diphenylimidazol-l-yl) -butyl] -3- pyridin-3 -yl-acrylamide; N- [4- (trans-2- phenylcyclopropylcarbonylamino) -butyl] -3 -pyridin-3 -yl- acrylamide; N- (5-hydroxy-5, 5-diphenyl-pentyl) -3-pyridin-3-yl- acrylamide; N- (7-phenylheptyl) -3 -pyridin-3 -yl-acrylamide; N- (4-diphenylacetylamino-butyl) -3-pyridin-3-yl-acrylamide; N- [4- (benzhydrylamino) -butyl] -3-pyridin-3-yl-acrylamide as well as N- (4-{ [2- (benzhydrylmethylamino) -ethyl] -methylamino} - butyl) -3-pyridin-3-yl-acrylamide . The compounds in the form of their pharmaceutically acceptable acid addition salts with inorganic or organic acids can also be present with respect to the various groups of compounds presented above whereby preferred examples for addition salts with suitable inorganic acids are represented by hydrochlorides, hydrobromides, hydroiodides, sulfates and phosphates and addition salts of organic acids are preferably represented by acetates, benzoates, citrates, fumarates, gluconates, malates, maleates, methanesulfonates, lactates, oxalates, succinates, tartrates and tosylates. These compounds can also optionally be present as hydrates or other solvates . This is also valid in the same manner for the stereoiosomers, which include the cis- and trans-isomers as well as E- and Z- isomers of the above defined compounds, especially in the case that D contains one or more double bonds, including the enantiomers, diastereomers and other isomers of the above defined compounds, in optionally pure form or as their racemic and/or non-racemic mixtures. A multitude of compounds according to the general formula (I) are previously described in the publications PCT/EP97/03243=WO97/48695 with the priority DE 196 24 704.7, PCT/EP97/03245=WO97/48696 with the priority DE 19624 659.8 and PCT/EP97/03244= O97/48397 with the priority DE 196 24 668.7 with respect to their known uses discussed there as well as their production. The remaining compound groups of the compounds according to the general formula (I) are subject matter of the older priority patent applications in comparison to the present application subject matter (i.e. not yet published at the present filing date). DE-19756212.4 dated 17.12.1997, DE-19756235.3 dated 17.12.1997, DE- 19756236.1 dated 17.12.1997 and DE-19756261.2, also dated 17.12.1997, whereby the compounds described therein are 50 distinguished namely by pharmacological, preferably cancerostatic activities. The production of the compounds falling under the general formula (I) as well as their sub-groups according to the above general formulas (la) to (Ic) is well-known to experts, Greater details on the production process in the form of so- called analogy methods, the starting materials (educts) and intermediate products (intermediates) necessary for this are disclosed in the above-mentioned PCT and/or DE patent applications . Preferably, compounds of the general formula (II) to (lib) >23 R2 OH OH R 2 :NT R" :N !*> R2 R 24 OH R' N > II ' (Ha) lib) as well as compounds of the formulas (III) to (IIIc) R23 >22 OH R2 OH ~N i > R21 >21 N ' I I I ' ( I l ia ) 51 O R22 ? 22 OH O " fi> R 21 :N i R 21 :N > R 24 > 24 (Illb) :ιιic) are applied and/or medicaments containing these are produced as compounds with vitamin PP activity, whereby in the above general formulas, R 21 is selected from hydrogen, halogen, cyano, alkyl, especially C^-C -alkyl, trifluoromethyl, hydroxyalkyl, especially C^-Cg- hydroxyalkyl , hydroxy, alkoxy, alkanoyloxy, alkylthio or aminoalkyl, especially C]_-Cg-alkoxy, C 1 -C 7 -alkanoyloxy, C^-Cg-alkylthio or Cχ-Cg-aminoalkyl, amino, alkylamino or dialkylamino, especially C^-Cg-alkylamino or C2-C 1 2- dialkylamino, formyl, alkoxycarbonyl, especially C2-C 7 - alkoxycarbonyl , aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl, especially C2-C7- alkylaminocarbonyl or C3-C 1 3-dialkylaminocarbonyl and carboxy; R 22 is selected from hydrogen, halogen, Alkyl, especially C^-Cg-alkyl, trifluoromethyl, hydroxyalkyl, especially C^-Cg- hydroxyalkyl , hydroxy, alkoxy, alkanoyloxy or aminoalkyl, especially C^-Cg-alkoxy, C1-C 7 -alkanoyloxy or C ] _-C -aminoalkyl, amino, alkoxycarbonyl, especially C2-C 7 -alkoxycarbonyl, aminocarbonyl and carboxy; R 23 is selected from hydrogen, alkyl, especially C 1 -Cg-alkyl, and hydroxyalkyl, especially C ] _-Cg-hydroxyalkyl; 52 R 24 is selected from alkyl, alkenyl, hydroxyalkyl, alkoxyalkyl, especially Ci-Cg-alkyl, C 3 -Cg-alkenyl , C 2 -C -hydroxyalkyl or C2-Cg- alkoxyalkyl and aralkyl, especially benzyl; X- signifies a monovalent, non-basic anion selected from fluoride, chloride, bromide, iodide, hydrogen sulfate, methanesulfonate, trifluoromethanesulfonate, tosylate, tetrafluoroborate, dihydrogen phosphate and acetate, whereby esters of the compounds of formula (III) in form of the following general formulas (IV) , their N-oxides (according to formula IVa) or quaternary salts (according to formula IVb) with mono- to hexavalent alcohols or amino alcohols, R 23 R23 o R" R 25 R2 S b °- R25 ^ > 21 R 21 ^ " (IV) ;iVa) can also optionally be used as compounds with vitamin PP activity, wherein 53 R 21 to R 24 and X" have the above meanings, a can be the number 1 to 6, and the underlying alcohol R 25 (OH) a is selected from monovalent, straight chained or branched, primary, secondary or tertiary C^-Ci Q -alkanols or ω-dialkylamino alkanols or benzyl alcohol, divalent, straight chained or branched C2 -C ] _Q -glycols, mono- or divalent C5-C 7 -cycloalkanols and/or-diols, cycloalkylmethanols or saturated heterocyclomethanols such as tetrahydrofurylmethanol, tri-, tetra-, penta- or hexavalent, straight chained or branched or cyclic alcohols with 3 to 10 carbon atoms such as glycerin, 2 , 2-bis (hydroxymethyl) -octanol-1, erythritol, pentaerythritol, arabitol, xylitol, sorbitol, mannitol, isosorbitol, tetra (hydroxymethyl) cyclohexanol or inositol, whereby the amides of the following formulas to (V) to (Vb) , with the exception of 6-amino nicotinamides derived from the respective free acids of the above general formulas (III) to (IIIc) , their N-oxides or quaternary salts with mono- or divalent amines or hydroxyalkylammes can also be optionally further used: R R22 N ' ' N d? R 26 R21 (V) 54 R 2 N ' '/ R26 R 1 + N I . O (Va) 23 - 27 R22 R26 R21 R24 (Vb) wherein R 21 to R 24 and X" have the above meanings, b can represent the number 1 or 2 and, in the case that b = 1, the residues R 2 *> and R 27 are selected independently from each other from hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl or dialkylaminoalkyl, especially C^-Cg-alkyl, C^-Cg- hydroxyalkyl , C3~C -alkoxyalkyl, C]_-Cg-aminoalkyl or C 4 -C 1 2" dialkylaminoalkyl and carboxymethyl, and in the case that b = 2, the residue R 2 ^ has the above meanings, the residue R 27 is selected from alkylene, especially C2-C]_Q-alkylene or C5-C10- 53 alkylene, wherein a methylene group is isosterically replaced by 0, NH or N-alkyl; and/or, depending on the molecular binding properties of the compounds according to the above formulas (II) to (Vb) , their acid addition salts, anionic salts, their N-oxides, especially according to the formulas (Ila) and (Ilia) , and quaternary pyridinium salts, especially according to the formulas (lib) , (Illb) and (IIIc) , optionally their respective analogous thioxo derivatives according to the general formulas (II) to (Vb) as well as a precursor compound (prodrug) as well are used which can be metabolized in vivo to a compound with vitamin PP activity or other pharmacologically acceptable esters or other derivatives not defined by the above substitutents with pharmacokinetically useful vitamin PP-activity. Their possible stereoisomers depending on the chemical structures, the cis- and trans-isomers as well as E- and Z- isomers including the enantiomers, diastereomers and other isomers in optionally pure form or as their racemic and/or non-racemic mixtures are also included, as well as the tautomers of the above defined compounds as well as the corresponding pharmacologically acceptable acid addition salts of the above defined compounds. Furthermore, for example, acid addition salts of the above compounds with organic acids such as acetates, ascorbates, benzoates, citrates, fumarates, gluconates, malates, maleates, methansulfonates, lactates, oxalates, succinates, tartrates and tosylates or inorganic acids such as hydrochlorides, hydrobromides, hydroiodides, sulfates and phosphates including their hydrates and solvates as well as the anionic salts, such as alkali and alkaline earth salts such as the sodium, potassium or magnesium and calcium salts and other salts such as aluminium salts are also included. 56 In a particularly preferred manner, nicotinic acid and/or the nicotinamide are used as vitamin PP active compounds. Preferably, compounds with vitamin PP activity and/or corresponding prodrugs according to the invention are used for example in the form of the following compounds, which fall, in part, under the general formulas (II) - (Vb) N 1 -alkylnicotinamide, such as, for example, N 1 - methylnicotinamide or N 1 -ethylnicotinamide, nicotinic acid diethylamide, diethylaminoethylnicotinate, fructofuranose- 1, 3, 4, 6-tetranicotinate, butoxyethylnicotinate, 2- diethylaminoethyl-p-nicotinamidobenzoate, nicotinoyl- procaine, N- { 3- [4- (p-fluoro-phenyl) -1-piperazinyl] -1- methylpropyl} -nicotinamide, nicotinylalcohol (3- pyridylcarbino) , tetrahydrofurfurylnicotinate, 2-hexyl-2- (hydroxymethyl) -1, 3-propandioltrinicotinate, 3-[α- (p- chlorphenoxy) -isobutyryloxy]-propylnicotinate, N- (α-methyl- phenethyl) -nicotinamide, N- (1, 2-diphenylethyl) -nicotinamide, morphindinicotinate, 4-nicotinamido-l, 5-dimethyl-2-phenyl-3- pyrazolone, N- (2-hydroxyethyl) -nicotinamide, optionally as a nitrate, 3-pyridylmethyl ester, 2- (4-chlorophenoxy) -2- methylpropionic acid, 1- (p-chlorophenyl) -isobutylnicotinate, 5-methoxy-2-methyl-l-nicotinoylindol-3-acetic acid, N-(2- hydroxymethyl) -nicotinamido-2- (p-chlorophenoxy) -2- methylpropionate, N- (hydroxymethyl) -nicotinamide, nicotindiethy1amid-N 1 -methylhydroxide, 4- nicotinoylmorpholine, 17β-hydroxy-4-andro-sten-3-on-17- nicotinate, estradiol-17-nicotinat-3-propionate, 4- (6, 7- dimethoxy-1-isoquinolylmethyl) -o-phenylendinicotinate, trans- 3, 3, 5-trimethylcyclohexylnicotinate, 1, 10-bis- (2-nico- tinoyloxyethylthio) -decane, 4, 5-epoxy-3-methoxy-N-methyl-7-morphinen-6-ylnicotinate, 4, 5-epoxy-3-methoxy-17-methylmorphinan-6-ylnicotinate, 4, 5-epoxy-17-methylmorphin-7-en-3, 6-diyldinicotinate, 17-allyl-4 , 5-epoxymorphin-7-en-3 , 6-diyldinicotinate, 2 , 3-dihydroxypropyl-2- ( 3-chloro-o-toluidino ) -nicotinate, 2-morpholinoethyl-2- (α, , α-trif luoro-m-toluidino ) - nicotinate, 2- ( 1 , 3-dichloroanilino) -nicotinic acid, 3- pyridylmethanolnicotinate, 3-hydroxymethylpyridine, optionally in form of the nicotinyltartrate or nicotinylmaleate, acetamidophenylnicotinate, N- (α- methylphenethyl) -thionicotinamide, N- ( 2 , 3-dimethyl-5-oxo-l-phenyl-3-pyrazolin-4-yl ) - nicotinamide, N-methyl-N- (2, 3-dimethyl-5-oxo-l-phenyl-3-pyrazolin-4-yl ) - nicotinamide, 4- (3-trifluoromethylanilino) -nicotinic acid, 2- (3-chloro-o-toluidino) -nicotinic acid, 2- (2-methyl-3- trifluoromethylanilino) -nicotinic acid, 2- (2, 3-xylidino) - nicotinic acid, 2- (2, 6-xylidino) -nicotinic acid, 2- (p- butylanilino) -nicotinic acid, 2-hydroxy-2 ' , 6'- nicotinoxylidide, N- (2, 3-dimethyl-5-oxo-l-phenyl-3-pyrazolin- 4-yl) - -nicotinamido-acetamide, N- (1, 2-diphenylethyl) - nicotinamide, N- ( 1-phenyl-heptyl) -nicotinamide, nicotinamide adenine dinucleotide, or N-[N-iso-propyl-N- (2, 3-dimethyl-5- oxo-l-phenyl-3-pyrazolin-4-yl) -aminomethyl]-nicotinamide . As further named compounds already partially mentioned under the above exemplified compounds or corresponding prodrugs as particularly preferred substances with vitamin PP activity which fall under the general formulas (II) - (Vb) , the following are named: the ethanolamine salt, sodium salt, aluminium salt or magnesium salt of the nicotinic acid, the (RS) -7-{2-hydroxy- 3-[2-hydroxyethyl) -methylamino]-propyl}-theophylline salt of the nicotinic acid, the N-oxide of the nicotinic acid, methyl-, ethyl-, 2-diethylaminoethyl-, 2-hydroxyethyl-, 2- aminoethyl-, propyl-, isopropyl-, 2-butoxyethyl-, 58 tetrahydrofurfuryl-, 3-pyridinylmethyl-, hexyl-, 2- diethylaminoethyl-, benzyl-, oxyethyl-theophyllin-, l-(4- chlorophenyl) -2-methylpropyl-, 2-[2- (4-chlorophenoxy) -2- methyl-l-oxopropoxy]-ethyl-, 2,5,7, 8-tetramethyl-2- (4,8, 12- trimethyltridecyl) -chroman-6-yl- or 3, 3, 5-trimethylcyclohexyl ester of nicotinic acid, dinicotinate of 7- (2, 3- dihydroxypropyl) -theophylline, trinicotinate of 2-hexyl-2- hydroxymethyl-1, 3-propantriol, tetranicotinate of pentaerythritol, 1, 3, 4, 6-tetranicotinate of d-fructofuranose, 1, 1, 3, 3-tetranicotinate of 2-hydroxy-l, 1, 3, 3- cyclohexantetramethanol, the 2 ' , 3 ' , 4 ' , 5 ' -tetra-nicotinate of riboflavin, the hexanicotinate of mesoinositol or the hexanicotinate of sorbitol, 2-methyl-3-carbomethoxy-5- (1,2,3, 4-tetranicotinoyloxybutyl) -furan, 8β-[ (5-bromonico- tinoyloxy) -methyl]-l, 6-dimethyl-10α-methoxy-ergoline, 3-pyr- idincarboxylic acid methylester methylhydroxide and optionally its iodide, 4-[ (3-pyridinylcarbonyl) -amino]- benzoic acid-2- (di-ethylamino) -ethyl ester, 7- (2-)- hydroxyethyltheophylline nicotinate, 2-[2- (4-chlorophenoxy) - 2-methyl-l-oxopropoxy]-ethylnicotinate, nicotinic acid methylbetaine, N^methylnicotinamide chloride or nicotinic acid diethylamide . Depending on the particular pharmacokmetics, for example, pH dependent pharmacokinetics, and particular metabolism, the named derivatives can have a prolonged effect optionally as a prodrug, or can be used topically, locally or regionally as a pharmaceutical with partially additional pharmacological effects such as increasing circulation, as analgesic agents or as morphine antagonists, especially in connection with the cancerostatic chemotherapy deployed according to the invention with the aim of neutralizing or decreasing side- effects . A further particularly preferred embodiment of the invention is in the use of tryptophan as a vitamin PP precursor compound which is metabolized in vivo to a compound with vitamin PP activity (prodrug) . According to the a further particularly preferred embodiment according to the invention, one or more cancerostatic or immunosuppressive compounds different from the tumor inhibitors according to the general formula (I) is used in addition to the compound mixture comprising a cancerostatic agent, especially a compound according to the general formula (I), plus a compound with vitamin PP activity. This means that in the use according to the invention of vitamin PP compounds and/or the combinations according to the invention with an amount of these compounds, further cancerostatic agents, optionally alone, are considered in addition to the anti-tumor compounds especially those of the general formula (I) , in cytostatic agents or immunosuppressive agents applied in chemotherapy in the form of the following compounds or compound groups : Alkylizing, cytostatic agents (alkylanizers) , for example derivatives without nitrogen such as cyclophosphamide, trofosfamide, ifosfamide, melphalane, mechloroethamine, chlorambucil as well as ethylenimine derivatives (aziridines) such as thiotepa. A further alkylizing compound would be for example busulfane. Additionally, among these exemplified alkylating cytostatic agents are carmustine, lomustine or nimustine, which can be considered in a wider sense as belonging to this compound group of alkylanizers as N- nitroso-urea derivatives. For example, procarbazine and dacarbazine also belong to these. Diaziquone, hexamethylmelamine, trimelamole or temozolamide are also referred to with respect to the series of alkylanizers. Examples for cancerostatic anti-metabolites are folic acid antagonists, such as methotrexate, edatrexate, trimetrexate or its ethyl derivative 10-ethyl-lO-desaza-aminopterine as well as purine and pyrimidine base antagonists or antagonists with other points of attack, for example, 6-mercaptopurine and 6-thioguanine, 5-fluorouracil, floxuridine, ara-c, hydroxyurea, desoxycoformycine, triazofurine, acivicine, PALA, pyrazofurine as well as cytarabine, vidarabine, fludarabine, desoxycoformycine, 2-chloro-2 ' -desoxy-adenosine or tiazofurine. In this connection, various IFN compounds, IL2 or leucovorine are particularly considered as synergists. A further important group of cancerostatic agents are represented by the platinum complexes such as cisplatin and carboplatin . Podophyllotoxins or epipodophyllotoxins as antimitotic agents such as etoposide or teniposide have achieved certain importance as cancerostatic agents. This is true in a similar manner for vincaalkaloids, for example vinblastin, vincristin, vindesin, navelbin or 17- desacetylvinblastin. Cytostatically effective antibiotics capable of being combined are also considered in connection with the invention such as, for example, actinomycins such as dactinomycin or actinomycin D, anthracyclines such as daunorubicin, doxorubicin, rubidazone, detorubicin, epirubicin, carminomycin, aclacinomycin A, marcellomycin, AD-32, THP- doxorubicin, esorubicin, idarubicin, menogaril, or mitoxantrone or bleomycin as well as mitomycin C with comparable antibiotic effects. Morpholinyl derivatives with the name MRA, MRA-MO, MRA-CN or MRD-nr-CN or the morpholinyl anthracycline derivative MX2 also belong to these. The series of the cancerostatic agents from different compound groups can be extended with newer compounds such as L-alanosine, amonafide, amsacrine, mafosfamide, bisantrene, carbethimer, desoxyspergualine, α-difluoromethylornithine, mitolactol, didemnine B, echinomycin, ellipticiniumacetate, gallium nitrate, optionally, cimetidine or retinoids, homoharringtonine, razoxane, indicin-N-oxide, lonidamine, menogaril, mitiguazone, N-methylformamide, mitozolamide, piritrexime, spirogermanium, spiromustin, suramin, taxol, taxoter, teroxirone, hydroxyurea, 1, 2, 4-triglyci-dylurazole, 1-asparaginase, lentinane, vinzolidine or radioactive isotopes such as 32 P, 90 Y, 211 At or 131 I, which can each be coupled to an antibody for targeting purposes. An important group of cancerostatic agents are represented by hormonal compounds, i.e. hormones themselves such as androgens/anti-androgens, glucocorticoids or estrogens/anti- estrogens, depot estrogens, gestagens as well as hormone antagonists/hypothalamus hormones, estrogen receptor antagonists or aromatase inhibitors. Among others, examples of compounds of this type are mentioned in the following: busereline, gosereline, leuproreline, triptoreline, such as for example, stilbestrol, diethylstilbestrol, megestrol (acetate) , diethyl-stilbestrol diphosphate, estradiol (undecylate) , gonadoliberine, fosfestrol, estramustine, tamoxifene, drostanolone (propionate) , fluoxymesterone, testolactone, aminoglutethimide, mitotane, medroxiprogesterone (acetate) flutamide, megestrol (acetate) , aminoglutethimide, 4-hydroxyandrostendione, plumestane, exemestane, pyridoglutethimide, fadrazole, arimidex, vorazole, flutamide, cyproterone, mifepristone, hydroxyprogesterone, progesterone or ethinylestradiol, For immunosuppressive therapies cyclosporine can be used for example, whereby corticosteroids, such as for example, 62 prednisone or methylprednisolol as well as methotrexate and azathioprine or cyclophosphamide can also be applied. A known combination of immunosuppressive agents of this type is the combined use of cyclosporine or prednisone together with azathioprine . Included in the series of the above customary, exemplified cancerostatic agents as well as cancerostatic agents not named here are pharmacolgically acceptable salts, esters, ethers, optic isomers, stereoisomers and other analogously effective derivatives depending on their structure. The preferred single doses of the cancerostatic agents and/or immunosuppressive agents are oriented in accordance with customary therapeutic recommendations given in the literature and company information. Depending on effectiveness and the therapeutic spectrum of the cytcostatic agents, they range for example from 0,1 mg up to 10 000 mg. Expressed in absolute dosage units, the unit doses can be 0.1, 0.2, 0.5, 1, 2, 5, 10, 20, 50, 75, 100, 150, 200, 300, 400, 500, 600, 750, 800, 900, 1000, in individual cases up to 1 200, 1 500, 2 000, 5 000 or 10 000 mg. In the case of the use of interferon compounds, the administered dosage amounts expressed in units are for example 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 40 or 50 million units. This is also true in a similar manner for cancerostatic enzymes, such as for example, asparaginases, which can be administered in an amount of 1000, 6000 or 10 000 units per m 2 body surface. The given dosage units also extend to the application of pyridylcarboxamide compounds according to the general formula (I), which can lie in the range between 0.1 mg, 1, 10 mg up to 5000 or 10 000 mg individual doses as discussed above. Depending on the existence of a synergistic, super-additive effect combination of two or more cancerostatic agents, the customary dosages can also be reduced. Therewith, the side- effects associated with the administration of cancerostatic agents can be further reduced. Conversely, if need be, considerably higher dose of cancerostatic agents can be administered without danger for patients in the case that the vitamin PP compounds reduce the side-effects in accordance with the invention. The above discussion of the respective suitable cancerostatic agents merely has an exemplifying character and no limiting character in any way because it cannot be complete as a result of the incalculable abundance of known medicaments; further customary cancerostatic agents and carrier systems for this are to be taken from relevant handbooks such as for example M.Peckham, H.Pinedo and U. Veronesi: Oxford Textbook of Oncology Vol. 1 & Vol. 2, Oxford University Press, Oxford, New York, Tokyo (1995) or . Forth, D.Henschler, . Rummel, , K.Starke: General and specific pharmacology, SPEKTRUM, Heidelberg, Berlin Oxford, 7. Edition (1996) or E. Mutschler: Medicament activities, textbook of pharmacology & toxicology, VG, Stuttgart, 6. Edition (1991) or other compendia and the remaining literature or the art on anti-tumor agents. In the use according to the invention, the dosage units of compounds of the general formula (I) respectively applied for the reduction, elimination or prevention of less severe side- effects lie in the range 5, 10, 20, 25, 30, 50, 75, 100, 200, 250, 300, 400, 500, 750 mg to 1000 mg and for eliminating a acute side-effects and/or neutralizing the cancerostatic agent effects lie in the range of 100, 250, 300, 500, 750 or 1000 up to 10 000 mg. Furthermore, medicaments are created according to the invention which are characterized in that they contain one or more compounds of the general formula (I) as well as one or more compounds of the above defined general formulas (II) to (Vb) aside from physiologically acceptable carriers and toxicologically safe adjuvants. Aside from cancerostatic chemotherapy, the medicaments and modes of use made available according to the invention are also connected with anti-proliferative therapy and metastases formation inhibiting, i.e. prophylactic, therapy or the control of immune reactions such as autoimmune diseases or tumor diagnostics. According to the invention, the above named medicaments can also be distinguished in that they contain one or more further cancerostatic or immunosuppressive compounds which are different from the compounds according to general formula (I) in addition to the cancerostatic agents, especially the tumor inhibitors according to the general formula (I) . In the above named indications, for example for reduction, elimination or prevention of less severe side-effects, the respective dosage units of compounds of the general formula (I) in the medicaments can be in the range of 5, 10, 20, 25, 30, 50, 100, 200, 250, 300, 500, 750, 1000 mg to 1000 mg and 100, 200, 250, 300, 500, 750 or 1000 to 10 000 mg for elimination of acute side-effects and/or for neutralization of cancerostatic agent effects. In addition to the cancerostatic agents in combination with one or several compounds of the general formulas (II) to (Vb) , the medicaments can contain one or more active ingredients customary in the indications given in the above claims. Preferably, the medicaments are present in a solid, peroral administrable form as a table, capsule, coated tablet, optionally as a sustained action and/or gastric fluid-resistant preparation, or as a liquid medicinal form, for example as a respective peroral administrable solution, OJ suspension effervescent tablet, in the form of tabs or sachets optionally, in sustained action form and/or with protracted and/or accelerated or controlled release of the active ingredients. Preferably, the above named medicinal forms are used in connection with the application according to the invention. Pursuant to a further preferred embodiment according to the invention, the medicaments are characterized in that the active ingredients combined with each other are contained separate from each other and/or in separate dosage units in the pharmaceutical package (kit-of-parts) . A further embodiment according to the invention relates to a medicament in the form of a suitable injection or infusion preparation together with suitable pharmaceutically acceptable carriers and adjuvants, optionally in sustained action form and/or as a parenteral depot form or implant or in the form of a concentrate, powder or lyophilisate, whereby the parenteral dilution agent can be optionally manufactured in the package separately therefrom such that the mixing of the compounds contained therein with the common parenterally applicable dilution agent is possible immediately before use. Furthermore, the medicament can preferably be in the form of an inhalation therapeutic agent, for example, in the form of a spray together with suitable pharmaceutically acceptable propellants, carriers and adjuvants, whereby the pharmaceutically acceptable carrier and/or diluent can be an aerosol propellant. Preferably, the medicament can also be present in the form of transdermal therapeutic system for systematic treatment. 66 Moreover, it can also preferably be present in the form of a gastro-intestinal therapeutic system (GITS) for systematic treatment . As a topical administrable medicament, it can preferably be formulated as a salve, suspension, emulsion, balm, or plaster or as an externally applicable solution. Further preferred embodiments of the medicament used or produced according to the invention are in the application forms of dose aerosols, dry powder dosage formulations, rectal genital or transurethral administrable emulsions, solutions, liposomal solutions, implants, suppositories or capsules . Equally, the medicaments used or compounded according to the invention are preferably in the form of compositions capable of being applied nasally, otologically or ophthalmologically in buccally applicable form. According to the invention, the dosage units applied or contained in the medicaments for single administration can be 0.001 up to 1000, 2000, 3000, 4000 or 5000 mg, preferably 0.01 - 100 mg, in a preferred manner 1 - 10 mg, especially 1, 2, 5, 10, 20, 25, 30, 50, 75, 100, 200, 300, 400, 500, 600 or 800 mg cancerostatic agent, especially a tumor inhibitor of the general formula (I) . In the case that the medicament is present as a propellant aerosol, one or more propellants can preferably be tetrafluoroethane and/or heptafluoropropane and/or propane, butane or dimethylether or their mixtures, whereby the propellant aerosol can contain surface adjuvants. In the case that the medicament is present as a dry powder dosage formulation, glucose and/or lactose can be contained as carrier agents. In a preferred manner, the medicament with an amount of a prodrug can have an amount of tryptophan, whereby, in this case, it preferably can contain 30-, 40-, 50- or 60-fold amount of this prodrug tryptophan in comparison to m nicotinamide as a vitamin PP reference substance for example, 500, 1000, 2000, 3000, 5000, 10 000 or 50 000 mg. The respective suitable or preferred dosage units for other prodrugs such as analogous esters and the like can easily be determined in individual cases based on the molecular portions and based on easily determined pharmacokmetic data for the patients and/or individual tumor type or other indication. The invention also relates to a method for treatment of the human or animal body which is characterized in that one of the above characterized compound mixtures as a medicament is processed in fixed combination with each other to a medicament or is applied in separate dosage units manufactured together or applied sequentially after each other in the above given dosage units in cytcostatic, antiproliferative, cancerostatic or immunosuppressive chemotherapy or chemotherapeutic inhibition of abnormal cell growth in chemotherapy, or as a diagnostic agent for prevention, reduction or elimination of side-effects including acute side-effects and/or for neutralization of the effect of cancerostatic agents and/or tumor inhibitors, immunosuppressive agents or diagnostic agents which were or are to be administered or in connection with the customary indications of particular chemotherapy mentioned above. 68 Therapeutic Administration Forms - Medicaments The production of medicaments with an amount of one or more compounds according to the invention and/or their use in the application according to the invention occurs in the customary manner by means of common pharmaceutical technology methods. For this, the active ingredients as such or in the form of their salts are processed together with suitable, pharmaceutically acceptable adjuvants and carriers to medicinal forms suitable for the various indications and types of application. Thereby, the medicaments can be produced in such a manner that the respective desired release rate is obtained, for example a quick flooding and/or a sustained or depot effect. Preparations for parenteral use, to which injections and infusions belong, are among the most important systematically employed medicaments for tumor treatment as well as for other indications . Preferably, injections are administered for the treatment of tumors. These are prepared either in the form of vials or also as so-called ready-to-use injection preparations, for example as ready-to-use syringes or single use syringes in addition to perforation bottles for multiple withdrawals. Administration of the injection preparations can occur in the form of subcutaneous (s.c), intramuscular (i.m.), intravenous (i.v.) or intracutaneous (i.e.) application. The respective suitable injection forms can especially be produced as solutions, crystal suspensions, nanoparticular or colloid-disperse systems, such as for example, hydrosols . The injectable formulations can also be produced as concentrates which can be adjusted with aqueous isotonic dilution agents to the desired active ingredient dosage. Furthermore, they can also be produced as powders, such as 69 for example lyophilisates, which are then preferably dissolved or dispersed immediately before application with suitable diluents. The infusions can also be formulated in the form of isotonic solutions, fat emulsions, liposome formulations, microemulsions and liquids based on mixed micells, for example, based on phospholipids . As with injection preparations, infusion formulations can also be prepared in the form of concentrates to dilute. The injectable formulations can also be applied in the form of continuous infusions as in stationary as well as in outpatient therapy, for example in the form of mini-pumps. Albumin, plasma expanders, surface active compounds, organic solvents, pH influencing compounds, complex forming compounds or polymeric compounds can be added to the parenteral medicinal forms, especially as substances for influencing the adsorption of the active ingredients to protein or polymers or also with the aim of decreasing the adsorption of the active ingredient to materials such as injection instruments or packaging materials, for example plastic or glass. Depending on the chemical structure and binding capability, the cancerostatic agents can be used in the form of conjugates with albumin or compounds none convalently bound to albumin for example; see for this among others the publications US-A-5 308 604, DE-A-195 14 087, DE-A-195 48 114, DE-A-196 02 295, DE-A-4 122 210, DE-A-4 433 890, DE-A-4 435 087, WO96/09071, 096/25956, 096/32134, PCT/DE/96/02487 or PCT/DE97/00166. Corresponding experiments were also undertaken with conjugates based on transferrin, cross-linked dextran, fibrinogen, casein or hemoglobin. Additionally, experiments to couple cancerostatics and/or their prodrugs with suitable antibodies used in tumor therapy seem to be promising. Combinations or monotherapies of this type with antibodies are therefore included within the present scope of the invention. Moreover, targeting experiments with albumin magnetically marked with magnetite (Fe 3 0 4 ) were undertaken in 70 order to enrich the tumor inhibitor in the form of so-called microballs (microspheres) in higher concentration at the place of action. Carrier systems of this type are suitable as targeting transport media to enable a targeted delivery of the pharmaceutical to the target organ. In this manner, protection of healthy tissue can be better ensured, a greater enrichment of the active ingredient can be obtained, and, finally, better protection of cancerostatic agents sensitive against biological degradation can be obtained during the transport to the place of action. For these purposes, active ingredient liposomes can be produced in a known manner by means of coating and/or embedding methods by coating suitable carriers, whereby the active ingredients are encapsulated within membranes having a thickness down to the nanometer range. With respect to the art on liposomal compositions, reference is made here to US-A-4 895 719 (=EP-A-0 223 831) and the publication WO-A-9 116 882 merely as representatives for many preparation methods. There are numerous types of microballs (microspheres) or microparticles based on different adjuvants as carrier systems such as lipoproteins of low density (low density lipoproteins) , activated charcoal particles, nanocapsules, nanoparticles, unilaminare or multilaminare vesicles (liposomes), polystyrol latex particles, microcapsules, whereby experiments with erythrocytes as a carrier medium were even carried out. For example polycyanoacrylates, polyacrylamide, gelatin based on cancerostatic agent/dextran conjugates, agarose, "ferromagnetic" ethylcellulose, poly (HEMA-BGA) , carnauba wax, starch, vesicles of non-ionic tensides (niosomes) , albumin/polyaspartic acid, phospholipids, viral sub-units (which lead to the formation of so-called virosomes) or polylactide (polylactic acid 71 ester) are considered as carriers for microparticle systems of this type. The active ingredients can be bound to nanoparticles in the preparations for parenteral use, for example on finely dispersed particles based on poly (meth) acrylates, polyacetates, polyglycolates, polyamino acids or polyether urethanes . The parenteral formulations can also be constructively modified as depot preparations, for example on the multiple unit principle, where the active ingredients are incorporated in a most finely distributed and/or dispersed, suspended form or as crystal suspensions, or on the single unit principle, where the active ingredient is enclosed in a medicinal form, for example, a tablet or a seed which is subsequently implanted. Often, these implantations or depot medicaments in single unit and multiple unit medicinal forms consist of so-called biodegradable polymers, such as for example, polyether urethanes of lactic and glycolic acid, polyether urethanes, polyamino acids, poly (meth) acrylates or polysaccharides . Sterilized water, pH value influencing substances, such as for example organic and inorganic acids or bases as well as their salts, buffer substances for setting the pH value, agents for isotonicity, such as for example sodium chloride, monosodium carbonate, glucose and fructose, tensides and/or surface active substances and emulsifiers, such as for example, partial fatty acid esters of polyoxyethylene sorbitan (Tween®) or for example fatty acid esters of polyoxethylene (Cremophor®) , fatty oils such as for example peanut oil, soybean oil and castor oil, synthetic fatty acid esters, such as for example ethyl oleate, isopropyl myristate and neutral oil (Miglyol®) as well as polymer adjuvants such as for example gelatine, dextran, polyvinylpyrrolidone, organic solvent additives which increase solubility, such as for example propylene glycol, ethanol, N,N-dimethylacetamide, propylene glycol or complex forming compounds such as for 72 example citrates and urea, preservatives, such as for example hydroxypropyl benzoate and hydroxymethyl benzoate, benzyl alcohol, anti-oxidants, such as for example sodium sulphite and stabilizers, such as for example EDTA, are suitable as adjuvants and carriers in the production of preparations for parenteral use. In suspensions, addition of thickening agents to prevent the settling of the active ingredients from tensides and peptizers, to secure the ability of the sediment to be shaken, or complex formers, such as EDTA, ensues. This can also be achieved with the various polymeric agent complexes, for example with polyethylene glycols, polystyrol, carboxymethylcellulose, Pluronics® or polyethylene glycol sorbitan fatty acid esters . The active ingredient can also be incorporated in liquid formulations in the form of inclusion compounds, for example with cyclodextrins . As further adjuvants, dispersion agents are also suitable. For production of lyophiliεates, builders are also used, such as for example mannite, dextran, saccharose, human albumin, lactose, PVP or gelatine varieties. As long as the active ingredients are not incorporated in the liquid medicinal formulations in the form of a base, they are used in the form of their acid addition salts, hydrates or solvates in the preparations for parenteral use. A further systemic application form of importance is peroral administration as tablets, hard or soft gelatine capsules, coated tablets, powders, pellets, microcapsules, oblong compressives, granules, chewable tablets, lozenges, gums or sachets . These solid peroral administration forms can also be prepared as sustained action and/or depot systems . Among these are medicaments with an amount of one or more micronized active ingredients, diffusions and erosion forms based on matrices, for example by using fats, wax-like and/or polymeric compounds, or so-called reservoir systems. As a 73 retarding agent and/or agent for controlled release, film or matrix forming substances, such as for example ethylcellulose, hydroxypropylmethylcellulose, poly (meth) acrylate derivatives (for example Eudragit®) , hydroxypropylmethylcellulose phthalate are suitable in organic solutions as well as in the form of aqueous dispersions. In this connection, so-called bio-adhesive preparations are also to be named in which the increased retention time in the body is achieved by intensive contact with the mucus membranes of the body. An example of a bio- adhesive polymer is the group of Carbomers® . For sublingual application, compressives, such as for example non-disintegrating tablets in oblong form of a suitable size with a slow release of active ingredient, are especially suitable. For purposes of a targeted release of active ingredients in the various sections of the gastrointestinal tract, mixtures of pellets which release at the various places are employable, for example mixtures of gastric fluid soluble and small intestine soluble and/or gastric fluid resistant and large intestine soluble pellets. The same goal of releasing at various sections of the gastrointestinal tract can also be conceived by suitably produced laminated tablets with a core, whereby the coating of the agent is quickly released in gastric fluid and the core of the agent is slowly released in the small intestine milieu. The goal of controlled release at various sections of the gastrointestinal tract can also be attained by multilayer tablets. The pellet mixtures with differentially released agent can be filled into hard gelatine capsules. Anti-stick and lubricant and separating agents, dispersion agents such as flame dispersed silicone dioxide, disintegrates, such as various starch types, PVC, cellulose esters as granulating or retarding agents, such as for example wax-like and/or polymeric compounds on the basis of Eudragit®, cellulose or Cremophor® are used as a further 74 adjuvants for the production of compressives, such as for example tablets or hard and soft gelatine capsules as well as coated tablets and granulates. Anti-oxidants, sweetening agents, such as for example saccharose, xylite or mannite, masking flavors, aromatics, preservatives, colorants, buffer substances, direct tableting agents, such as for example microcrystalline cellulose, starch and starch hydrolysates (for example Celutab®) , lactose, polyethylene glycols, polyvinylpyrrolidone and dicalcium phosphate, lubricants, fillers, such as lactose or starch, binding agents in the form of lactose, starch varieties, such as for example wheat or corn and/or rice starch, cellulose derivatives, for example methylcellulose, hydroxypropylcellulose or silica, talcum powder, stearates, such as for example magnesium stearate, aluminium stearate, calcium stearate, talc, siliconized talc, stearic acid, acetyl alcohol or hydrated fats, etc. are also used. In this connection, oral therapeutic systems constructed especially on osmotic principles, such as for example GIT (gastrointestinal therapeutic system) or OROS (oral osmotic system) , are also to be mentioned. Effervescent tablets or tabsolute both of which represent immediately drinkable instant medicinal forms which are quickly dissolved or suspended in water are among the perorally administrable compressives. Among the perorally administrable forms are also solutions, for example drops, juices and suspensions, which can be produced according to the above given method, and can still contain preservatives for increasing stability and optionally aromatics for reasons of easier intake, and colorants for better differentiation as well as antioxidants and/or vitamins and sweeteners such as sugar or artificial sweetening agents. This is also true for inspissated juices 75 which are formulated with water before ingestion. Ion exchange resins in combination with one or more active ingredients are also to be mentioned for the production of liquid injectable forms. A special release form consists in the preparation of so- called floating medicinal forms, for example based on tablets or pellets which develop gas after contact with body fluids and therefore float on the surface of the gastric fluid. Furthermore, so-called electronically controlled release systems can also be formulated by which active ingredient release can be selectively adjusted to individual needs. A further group of systemic administration and also optionally topically effective medicinal forms are represented by rectally applicable medicaments . Among these are suppositories and enema formulations. The enema formulations can be prepared based on tablets with aqueous solvents for producing this administration form. Rectal capsules can also be made available based on gelatine or other carriers . Hardened fat, such as for example Witepsol®, Massa Estarinum®, Novata®, coconut fat, glycerol-gelatine masses, glycerol-soap-gels and polyethylene glycols are suitable as suppository bases. For long-term application with a systematic active ingredient release up to several weeks, pressed implants are suitable which are preferably formulated on the basis of so-called biodegradable polymers . As a further important group of systematically active medicaments, transdermal systems are also to be emphasized which distinguish themselves, as with the above-mentioned rectal forms, by circumventing the liver circulation system and/or liver metabolism. These plasters can be especially 76 prepared as transdermal systems which are capable of releasing the active ingredient in a controlled manner over longer or shorter time periods based on different layers and/or mixtures of suitable adjuvants and carriers. Aside from suitable adjuvants and carriers such as solvents and polymeric components, for example based on Eudragit®, membrane infiltration increasing substances and/or permeation promoters, such as for example oleic acid, Azone®, adipinic acid derivatives, ethanol, urea, propylglycol are suitable in the production of transdermal systems of this type for the purpose of improved and/or accelerated penetration. As topically, locally or regionally administration medicaments, the following are suitable as special formulations: vaginally or genitally applicable emulsions, creams, foam tablets, depot implants, ovular or transurethral administration instillation solutions . For opthalmological application, highly sterile eye ointments, solutions and/or drops or creams and emulsions are suitable. In the same manner, corresponding otological drops, ointments or creams can be designated for application to the ear. For both of the above-mentioned applications, the administration of semi-solid formulations, such as for example gels based on Carbopols® or other polymer compounds such as for example polyvinylpyrolidone and cellulose derivatives is also possible. For customary application to the skin or also to the mucus membrane, normal emulsions, gels, ointments, creams or mixed phase and/or amphiphilic emulsion systems (oil/water- water/oil mixed phase) as well as liposomes and transfersomes can be named. Sodium algenate as a gel builder for production of a suitable foundation or cellulose derivatives, such as for example guar or xanthene gum, inorganic gel builders, such as for example aluminium hydroxides or bentonites (so- called thixotropic gel builder) , polyacrylic acid 77 derivatives, such as for example Carbopol®, polyvinylpyrolidone, microcrystalline cellulose or carboxymethylcellulose are suitable as adjuvants and/or carriers. Furthermore, amphiphilic low and high molecular weight compounds as well as phospholipids are suitable. The gels can be present either as hydrogels based on water or as hydrophobic organogels, for example based on mixtures of low and high molecular paraffin hydrocarbons and Vaseline. Anionic, cationic or neutral tensides can be employed as emulsifiers, for example alkalized soaps, methyl soaps, amine soaps, sulfonated compounds, cationic soaps, high fatty alcohols, partial fatty acid esters of sorbitan and polyoxyethylene sorbitan, for example lanette types, wool wax, lanolin, or other synthetic products for the production of oil/water and/or water/oil emulsions. Hydrophilic organogels can be formulated, for example, on the basis of high molecular polyethylene glycols. These gel-like forms are washable. Vaseline, natural or synthetic waxes, fatty acids, fatty alcohols, fatty acid esters, for example as mono-, di-, or triglycerides, paraffin oil or vegetable oils, hardened castor oil or coconut oil, pig fat, synthetic fats, for example based on acrylic, caprinic, lauric and stearic acid, such as for example Softisan® or triglyceride mixtures such as Miglyol® are employed as lipids in the form of fat and/or oil and/or wax-like components for the production of ointments, creams or emulsions. Osmotically effective acids and bases, such as for example hydrochloric acid, citric acid, sodium hydroxide solution, potassium hydroxide solution, monosodium carbonate, further buffer systems, such as for example citrate, phosphate, tries-buffer or triethanolamine are used for adjusting the pH value . 78 Preservatives, for example such as methyl- or propyl benzoate (parabenes) or sorbic acid can be added for increasing stability. Pastes, powders or solutions are to be mentioned as further topically applicable forms. Pastes often contain lipophilic and hydrophilic auxiliary agents with very high amounts of fatty matter as a consistency-giving base. Powders or topically applicable powders can contain for example starch varieties such as wheat or rice starch, flame dispersed silicon dioxide or silica, which also serve as diluents, for increasing flowability as well as lubricity as well as for preventing agglomerates . Nose drops or nose sprays serve as nasal application forms . In this connection, nebulizers or nose creams or ointments can come to use . Furthermore, nose spray or dry powder formulations as well as controlled dosage aerosols are also suitable for systemic administration of the active ingredients. These pressure and/or controlled dosage aerosols and dry powder formulations can be inhaled and/or insufflated. Administration forms of this type also certainly have importance for direct, regional application in the lung or bronchi and larynx. Thereby, the dry powder compositions can be formulated for example as active ingredient-soft pellets, as an active ingredient-pellet mixture with suitable carriers, such as for example lactose and/or glucose. For inhalation or insufflation, common applicators are suitable which are suitable for the treatment of the nose, mouth and/or pharynx. The active ingredients can also be applied by means of an ultrasonic nebulizing device. As a propellant gas for aerosol spray formulations and/or controlled dosage aerosols, tetrafluoroethane or HFC 134a and /or heptafluoropropane or HFC 227 are suitable, wherein non- 79 fluorinated hydrocarbons or other propellants which are gaseous at normal pressure and room temperature, such as for example propane, butane or dimethyl ether can be preferred. Instead of controlled dosage aerosols, propellant-free, manual pump systems can also be used. The propellant gas aerosols can also suitably contain surface active adjuvants, such as for example isopropyl myristate, polyoxyethylene sorbitan fatty acid ester, sorbitan trioleate, lecithins or soya lecithin. For regional application in situ, solutions for instillation, for example for transurethral administration in bladder tumors or genital tumors, or for profusion in liver tumors or other organ carcinomas are suitable. The respective suitable medicinal forms can be produced in accordance with the prescription and procedures based on pharmaceutical-physical fundamentals as they are described for example in the following handbooks and are included in the present inventive subject-matter with respect to the production of the respective suitable medicaments: Physical Pharmacy (A.N. Martin, J. Swarbrick, A. Cammarata) , 2nd Ed., Philadelphia Pennsylvania, (1970), German version: Physikalische Pharmazie, (1987) , 3rd edition, Stuttgart; R. Voigt, M. Bornschein, Lehrbuch der pharmazeutischen Technologie, Verlag Chemie, Weinheim, (1984) , 5th edition; P.H. List, Arzneimformenlehre, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, (1985) , 4th edition; H. Sucker, P. Fuchs, P. Speiser, Pharmazeutische Technologie, Georg Thieme Verlag, Stuttgart - New York, (1991) , 2nd edition; 80 A.T. Florence, D. A twood, Physicochemical Principles of Pharmacy, The Maximilian Press Ltd., Hong Kong, (1981); L.A. Trissel, Handbook on Injectable Drugs, American Society of Hospital Pharmacists, (1994) , 8th edition; Y.W. Chien, Transdermal Controlled Systemic Medications, Marcel Dekker Inc., New York - Basel, (1987); K.E. Avis, L. Lachmann, H.A. Liebermann, Pharmaceutical Dosage Forms: Parenteral Medications, volume 2, Marcel Dekker Inc., New York - Basel, (1986); B.W. Muller, Controlled Drug Delivery, Paperback APV, volume 17, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, (1987) ; H. Asch, D. acetic , P.C. Schmidt, Technologie von Salben, Suspensionen and Emulsionen, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, (1984) ; H.A. Liebermann, L. Lachman, J.B. Schwartz, Pharmaceutical Desage forms: Tablets, Volume 1, Marcel Dekker Inc., New York, 2nd Edition (1989) ,- D. Chulin, M. Deleuil, Y. Pourcelot, Powder Technology and Pharmaceutical Processes, in J.C. Williams, T. Allen, Handbook of Powder Technology, Elsevier Amsterdam - London - New York - Tokyo, (1994) ; J.T. Carstensen, Pharmaceutical Principles of Solid Dosage Forms, Technomic Publishing Co., Inc., Lancaster - Basel, (1993) . 81 PRODUCTION EXAMPLES FOR MEDICAMENTS A. Separately administrable or separately packaged medicinal forms with an amount of cancerostatic agent 1.1 Injection therapeutics a) Parenteral Solution cancerostatic agent used according to the invention 5.000 g acid sodium phosphate 5.000 g sodium tartrate 12.000 g benzyl alcohol 7.500 g water for injection purposes to 1000.000 ml The solution is produced according to the customary method, sterilized and filled into 10 ml vials. One vial contains 50 mg of the cancerostatic agent according to the invention. b) Parenteral Solution cancerostatic agent used according to the invention 1.000 g hydrochloric acid, dilute 5.000 g sodium chloride 6.000 g water for injection purposes to 1000.000 ml The solution is produced according to a customary method by stirring; the medicinal form is adjusted to a suitable pH value by acid addition and subsequently filled into 100 ml vials and sterilized. A vial contains 100 mg of the compound according to the invention. 82 c) Parenteral Dispersion cancerostatic agent used according to the invention 10.000 g soya lecithin 20.000 g saturated triglycerides 100.000 g sodium hydroxide 7.650 g water for injection purposes to 1000.000 ml The cancerostatic agent used according to the invention is dispersed in the saturated triglycerides . Then the soya lecithin is added under stirring, and subsequent to this, the aqueous solution of sodium hydroxide is added with subsequent homogenization. The dispersion is sterilized and filled into 10 ml vials. A vial contains 50 mg of the compound according to the invention. d) Biodegradable Parenteral Depot Medicinal Form cancerostatic agent used according to the invention 10.000 g polylactic acid /polygylcolic acid polymer 70.000 g polyvinylpyrrolidone 0.200 g gelatine 2.000 g soya lecithin 2.000 g isotonic sodium chloride solution to 1000.000 ml First, the active ingredient is incorporated into the biodegradable polymer comprising polylactic acid and polyglycolic acid by a suitable method (spray drying, solvent-evaporation or phase separation) and subsequently subjected to a sterilization process. The particles are introduced into a 2-chamber ready-made syringe in which the adjuvant solution, which is also produced in a sterile manner, is filled. The biodegradable microparticles are mixed with the dispersion agent shortly before application and dispersed. A ready-made syringe contains 200 mg of the cancerostatic agent according to the invention. 83 e) Parenteral Dispersion for Subcutaneous Instillation cancerostatic agent used according to the invention 25,000 g soya lecithin 25,000 g arachis oil 400,000 g benzyl alcohol 50,000 g Miglyole ® to 1000,000 g The active ingredient is dispersed together with soya lecithin and arachis oil. The benzyl alcohol is dissolved in Miglyole and added to the dispersion. The entire dispersion is sterilized and subsequently filled into vials with 2 ml content. A vial contains 50 mg cancerostatic agent. f) Parenteral Perfusions Solution The solution named under example 1.1.b) can also be used for perfusion of the liver for example. According to need, instead of ampules with injection solution, so-called perforation bottles (vials) , which can also be optionally preserved, and infusion solutions with an amount of one or more active ingredients according to the invention can also be made available in the customary manner under addition of buffer substances for adjustment of physiological pH value and/or the isotonicity and/or a best possible suitable pH value for the medicinal form (euhydria) and optional further required nutrients, vitamins, amino acids, stablizers and other necessary adjuvants, possibly in combination with further medicinal agents suitable for the mentioned indications . 84 1.2 Solid, Peroral Administrable Medicaments a) Tablets cancerostatic agent used according to the invention 10.000 g lactose 5.200 g starch, soluble 1.800 g hydroxypropylmethylcellulose 900 g magnesium stearate 100 g The above components are mixed with each other and compacted in a conventional manner, wherein a tablet weight of 180 mg is set. Each tablet contains 100 mg cancerostatic agent. If desired, the tablets obtained in this manner are coated, provided with a film coat and/or enterically coated. b) Coated Tablet Core cancerostatic agent used according to the invention 10.000 g high (X-ray) dispersed silicon dioxide 500 g corn starch 2.250 g stearic acid 350 g ethanol 3.0 1 gelatine 900 g purified water 10.0 1 talcum 300 g magnesium stearate 180 g From these components, a granulate is produced which is pressed to the desired coated tablet cores. Each core contains 50 mg of tumor inhibitor. The core can be further processed in a customary manner to coated tablets. If desired, a gastric fluid resistant or retarding film coat can be applied in a known manner. 85 c) Vials for drinking cancerostatic agent used according to the invention 0.050 g glycerine 0.500 g sorbite, 70% solution 0.500 g sodium saccharinate 0.010 g methyl-p-hydroxybenzoate 0.040 g aromatic agent q.s. sterile water q.s. to 5 ml The above-mentioned components are mixed in a customary manner to a suspension and filled in a suitable drink vial having 5 ml content . d) Poorly Soluble Sublingual Tablets cancerostatic agent used according to the invention 0.030 g lactose 0.100 g stearic acid 0.004 g talcum purum 0.015 g sweetener q.s. aromatic agent q.s. rice starch q.s. to 0.500 g The active ingredient is compacted together with the adjuvants under high pressure to sublingual tablets, favourably in oblong form. e) Soft Gel Capsule cancerostatic agent used according to the invention 0.050 g fatty acid glyceride mixture (Miglyole ® ) q.s. to 0.500 g The active ingredient is impasted together with the fluid carrier mixture and mixed together with further adjuvants 86 suitable for the encapsulation and filled into elastic soft gelatine capsules which are sealed. f) Hard Gelatine Capsules cancerostatic agent used according to the invention 0.150 g microcrystalline cellulose 0.100 g hydroxypropylmethylcellulose 0.030 g mannite 0.100 g ethylcellulose 0.050 g triethyl citrate 0.010 g The active ingredient is mixed together with the adjuvants, microcrystalline cellulose, hydroxypropylmethylcellulose and mannite, wet with granulation liquid and formed into pellets. These are subsequently coated with a solution of ethylcellulose and triethyl citrate in organic solvents in a fluidized-bed apparatus. A hard gelatine capsule contains 150 mg of active ingredient . 1.3 Topically Administrable Medicinal Forms a) Hydrophilic Ointment cancerostatic agent used according to the invention 0.500 g Eucerinum ® anhydricum 60.000 g microcrystalline wax 15.000 g Vaseline oil q.s. to 100.000 g The above-mentioned adjuvants are melted and further processed together with the tumor inhibitor to an ointment in a customary manner. 87 b) Lipophilic Ointment cancerostatic agent used according to the invention 10.000 g propylene glycol 50.000 g paraffin, liquid 100.000 g paraffin wax 100.000 g Vaseline to 1000.000 ml The cancerostatic agent used according to the invention is dissolved in propylene glycol at ca. 60°C. At the same time, the lipophilic components are melted at 60-70°C and subsequently combined with the active ingredient solution. The ointment is emulsified at first at 60-70°C and subsequently cooled to 35-40°C under constant emulsification and then filled in 10 g tubes. A tube contains 100 mg of the cancerostatic agent. 1.4 Inhalation Therapeutic Agent Further subject-matter of the use according to the invention are pharmaceutical formulations which are characterized in that they contain one or more cancerostatic agents used according to the invention as a base or a physiologically acceptable salt thereof together with carriers and/or diluents customary for this and suitable for administration by means of inhalation. In this connection, particularly suitable physiologically acceptable salts of the active ingredients are, as already illustrated in the description section, acid addition salts derived from inorganic or organic acids such as for example especially hydrochloride, hydrobromide, sulfate, phosphate, maleate, tartrate, citrate, benzoate, 4-methoxybenzoate, 2- or 4-hydroxybenzoate, 4-chlorobenzoate, p-tosylate, methane sulfonate, ascorbate, salicylate, acetate, formate, succinate, lactate, glutarate, gluconate or tricarballylate. 88 The administration of the cancerostatic agents used according to the invention by means of inhalation occurs in conventional ways customary for administrations of this type, for example in the form of a commercial controlled dosage aerosol or in combination with a spacer. In controlled dosage aerosols, a metering valve is delivered with whose help, a dosed amount of the composition is administered. For spraying, the present compositions can be formulated for example as aqueous solutions or suspensions and be administered by means of an atomizer. Aerosol spray formulations in which the active ingredient is either suspended with one or two stabilizers in a propellant as a carrier and/or diluent, for example tetrafluoroethane or HFC 134a and/or heptafluoropropane or HFC 227 can equally be used, whereby however, non-fluorinated hydrocarbons or other propellants which are gaseous at normal pressure and room temperature, such as propane, butane or dimethyl ether, can be preferred. Thereby, propellant-free manual pump systems or dry powder systems as described below can also be used. Suitably, the propellant aerosols can also contain surface active adjuvants, such as for example isopropyl myristate, polyoxyethylene sorbitan fatty acid ester, sorbitan trioleate, lecithins, oleic acid. For administration by means of inhalation and/or insufflation, the medicaments with an amount of compounds according to the invention can also be formulated in the form of dry powder compositions, for example as active ingredient- soft pellets or as an active ingredient-powder mixture with a suitable carrier, such as for example lactose and/or glucose. The powder compositions can be formulated and administered as single doses or as multiple doses. The cancerostatic agent and/or tumor inhibitors according to the invention are preferably administered by means of a controlled dosage aerosol or in the form of a dry powder 89 dosage formulation, wherein the latter preferably contains glucose and/or lactose as a carrier substance. As applicators for inhalation of the pharmaceutical formulations containing one or more of the cancerostatic agents used according to the invention, all applicators are generally suitable which are suitable for controlled dosage aerosols and/or a dry powder dosage formulation, such as for example usual applicators for the nose, mouth and or pharynx, or also devices standing under propellant gas for the delivery of a spray (as controlled dosage aerosol or dry powder dosage formulation) as they are also used for inhalations in the nose, mouth and/or pharynx. A further embodiment can also consist of an aqueous solution of the cancerostatic agents considered which also optionally contains further active ingredients and/or additives that are applied by means of an ultrasound atomizer. Controlled Dosage Aerosol a) Intended dose per aerosol per stroke % by weight cancerostatic agent 0.500 mg 0.66 stabilizer 0.075 mg 0.10 HFC 134a 75.500 mg 99.24 Controlled Dosage Aerosol b) Intended dose per aerosol per stroke % by weight cancerostatic agent 0.250 mg 0.32 Stabilizer 0.038 mg 0.05 HFC 227 79.180 mg 99.63 90 In the examples a) and b) the micronized cancerostatic agent is, after previous dispersion in a small amount of the stabilizer, placed in a suspension vessel in which the bulk amount of propellant gas solution is found. The corresponding suspension is dispersed by means of a suitable stirring system (for example high performance mixer or ultrasound mixer) until an ultra-fine dispersion results. The suspension is then continuously held in flux in a filling apparatus suitable for cold propellants or pressure fillings. Alternatively, the suspension can also be produced in a suitable cooled stabilizer solution in HFC 134a/227. The examples c) to d) describe the composition and production of dosage dry powder formulations . c) Dosage-Dry Powder Formulation mg/dose cancerostatic agent used according to the invention 0.500 mg d) Dosage-Dry Powder Formulation mg/dose cancerostatic agent used according to the invention 0.500 mg lactose Ph.Eur. up to 2.5 mg or up to 5.0 mg 91 e) Dosage-Dry Powder Formulation mg/dose cancerostatic agent used according to the invention 0.250 mg lactose Ph.Eur. up to 2.5 mg or up to 5.0 mg In example c) the cancerostatic agent is formulated after micronization under addition of steam in the form of pellets with an MMAD between 0 , 1 and 0 , 3 mm diameter and brought to use in a multi-dose powder applicator. In the examples d) and e) the cancerostatic agent is micronized, thereafter, bulk material is mixed with the lactose in the given amounts, and subsequently, filled in a multi-dose powder inhalator. In all of the above described examples, active ingredients or the medicinals can be present in the form of the respective suitable pharmaceutically acceptable salts and/or acid addition salts as long as the base is not preferred in the individual case . Preferably, the tumor inhibitors of the general formula (I) , but also suitably effective cancerostatic agents of the remaining art can be used as cancerostatic agents in the above medicaments provided as examples, above all as they are described in Section E below for the combined use according to the invention for illustration of the invention. 92 B. Medicinal forms with an amount of vitamin PP compounds for separate administration or packaging in a combination medicament (kit-of-parts) 2.1 Injection therapeutics a) Parenteral Solution nicotinamide 25.000 g sodium chloride 4.500 g water for injection purposes to 1000.000 ml The solution is produced according to the customary method, sterilized and filtered into 2 ml vials. A vial contains 50 mg nicotinamide (niacinamide) . This medicinal substance can be replaced by another given vitamin PP compound or a compound effective as vitamin PP. b) Parenteral Solution nicotinamide 10.000 g sodium chloride 6.750 g water for injection purposes to 1000.000 ml The solution is produced according to the customary method, filled into 100 ml vials and sterilized. A vial contains 1000 mg nicotinamide (niacinamide) . The medicinal substance can be replaced by another given vitamin PP compound or a compound effect as Vitamin PP. 93 2.2 Peroral administrable medicament a) Tablets nicotinamide 2,000 g microcristalline cellulose 750 g corn starch 2,000 g talcum 250 g The above components are mixed with each other and compacted in a conventional manner. The tablet weight is 500 mg. Each tablet contains 200 mg nicotinamide. If desired, a gastric fluid-resistant or sustained action film coating can be applied in an known manner. b) Tablets tryptophan 5,000 g microcristalline cellulose 1,070 g corn starch 2,000 g hydroxypropylmethylcellulose 250 g silicon dioxide 120 g magnesium stearate 60 g From the above components, a granulate is produced which is pressed to tablets. Each tablet contains 500 mg tryptophan with a tablet weight of 850 mg. c) Coated Tablet Core nicotinic acid 10,000 g lactose 3,500 g microcristalline cellulose 2,200 g corn starch 3,500 g 94 hydroxypropylcellulose 600 g magnesium stearate 200 g From the above ingredients, a granulate is produced which is pressed to coated tablet cores. Each core contains 100 mg nicotinic acid with a core weight of 200 mg. The core can be further processed in a customary manner to coated tablets. d) Vials for drinking nicotinamide 0.050 g sorbite, 70 % solution 1.000 g sodium saccharinate 0.010 g aromatic agent q.s. water to 5.000 ml The above mentioned components are mixed in a customary manner and filled into suitable drink vials having 5 ml content . e) Hard Gelatin Capsules nicotinamide 0.100 g microcristalline cellulose 0.150 g hydroxypropylcellulose 0.030 g mannite 0.100 g All components are mixed, moistened with granulation liquid and formed to pellets. The pellets can be filled in hard gelatin capsules either directly or after they after been provided with a functional coating. A capsule contains 100 mg nicotinamide. As a result of the multi-particulate medicinal pellets, the possibility also exists to fill differently coated pellets in a hard gelatin capsule. Two possibilities are to be particularly named. On the one hand, 95 gastric fluid resistant pellets can be filled together with sustained action pellets. On the other hand, gastric fluid- resistant pellets can also be combined with one or more other sorts of pellets or other working forms which release the active ingredient at different pH values of the surroundings. In the above described medicinal forms, nicotinamide (niacinamide) can also be replaced by another given vitamin PP compound or a compound effective as vitamin PP, for example in the form of nicotinic acid or its derivatives. 2.3 Topical administrable medicinal forms a) Eye drops nicotinamide 100.0 mg hydroxyethylcellulose 2.0 mg benzalkonium chloride 0.1 mg sterile water to 10.0 ml The hydroxyethylcellulose is given to the source in a portion of water. The other components are dissolved in the residual water and subsequently combined with the hydroxyethylcellulose solution and filled into eye drop bottles. b) Eye gel nicotinamide 0.500 g carbomer 0.020 g polyvinylpyrrolidone 0.600 g sodium hydroxide solution q.s. sterile water to 10.000 g The carbomer is dispersed in a portion of water. The nicotinamide and the polyvinylpyrrolidone are dissolved in 96 the other portion and subsequently both partial amounts are combined. The addition of the sodium hydroxide solution occurs thereafter. In the above topical and/or local or other regional adminstrable medicinal forms, nicotinamide (niacinamide) can also be replaced by another given vitamin PP compound or a compound effective as vitamin PP, for example in the form of nicotinic acid or its derivatives. 2.4 Inhalation therapeutic agent a) End contents nicotinamide 100.0 mg sodium chloride 67.5 mg sterile water to 10.0 ml After dissolving the components in water, the solution is sterilely filled in a suitable container (for example: bottle pack method) . The application can occur with commercial atomizers, for example ultra sound atomizers. C. Vitamin PP compounds in fixed combination with one or more tumor inhibitors. The following Examples for combination medicinal forms listed under Item 3 can be used according to the invention, especially in the reduction of side-effects, preferably in the dosage region of 10 - 1000 mg nicotinamide or suitably adjusted dosage of other vitamin PP compounds. 3.1 Injection therapeutic agent a) Parenteral solution 97 tumor inhibitor 5.000 g nicotinamide 5.000 g sodium hydrogen phosphate 4.500 g sodium tartrate 11.000 g benzylalkohol 7.500 g water for injection purposes to 1000.000 ml The solution is produced according to the customary method, sterilized and filled in 10 ml vials. A vial contains 50 mg tumor inhibitor and 50 mg nicotinamide. b) Parenteral solution tumor inhibitor 1.000 g nicotinic acid 2.000 g hydrochloric acid, diluted 4.000 g sodium chloride 5.900 g water for injection purposes to 1000.000 ml The solution is produced according to a customary method; the solution is adjusted to a suitable pH value by addition of acid and subsequently filled in 100 ml vials and sterilized. A vial contains 100 mg tumor inhibitor and 200 mg nicotinic acid. c) Biodegradable parenteral depot medicinal form tumor inhibitor 5.000 g nicotinamide 5.000 g polylactic acid/polyglycolic acid polymer 70.000 g polyvinylpyrrolidone 0.200 g gelatin 2.000 g soya lecithin 2.000 g 98 isotonic sodium chloride solution to 1000.000 ml First, the active ingredient is incorporated into the biodegradable polymer comprising polylactic acid and polyglycolic acid by a suitable method (spray drying, solvent-evaporation or phase separation) and subsequently subjected to a sterilization process. The particles are introduced into a 2 -chamber ready-made syringe in which the adjuvant solution, which is also produced in a sterile manner, is filled. The biodegradable microparticles are mixed with the dispersion agent shortly before application and dispersed. The content of a ready-made syringe is measured such that this contains 100 mg of the tumor inhibitor and 100 mg nicotinamide. d) Parenteral perfusions solution The solutions named under Example 3.1.b) can also be used for perfusion of the liver for example. According to need, instead of ampules with injection solution, so-called perforation bottles (vials) , which can also be optionally preserved, and infusion solutions with an amount of one or more active ingredients according to the invention can also be made available in the customary manner under addition of buffer substances for adjustment of physiological pH value and/or the isotonicity and/or a best possible suitable pH value for the medicinal form (euhydria) and optional further required nutrients, vitamins, amino acids, stablizers and other necessary adjuvants, possibly in combination with further medicinal agents suitable for the mentioned indications. In the above described parenteral agents, nicotinamide (niacinamide) can also be replaced by one or more other given vitamin PP compounds or other compounds effective as vitamin 99 PP, for example in the form of nicotinic acid or its derivatives . 3.2 Peroral administrable medicaments a) Tablets tumor inhibitor 500 g nicotinamide 1,500 g microcristalline cellulose 750 g corn starch 2,000 g talcum 250 g The above components are mixed with each other and compacted in a conventional manner. The tablet weight amounts to 500 mg. Each tablet contains 50 mg tumor inhibitor and 150 mg nicotinamide. If desired, a gastric fluid-resistant or sustained action film-coating can also be applied in a known manner . b) Coated tablet cores tumor inhibitor 3,000 g nicotinic acid 5,000 g lactose 4,500 g microcristalline cellulose 2,700 g corn starch 4,000 g hydroxypropylcellulose 600 g magnesium stearate 200 g From the above components, a granulate is produced which is pressed to coated tablet cores. Each core contains 30 mg tumor inhibitor and 50 mg nicotinic acid with a core weight of 200 mg. The core can be further processed to coated tablets in a customary manner. 100 c) Vials for drinking tumor inhibitor 0.020 g nicotinamide 0.050 g Sorbite, 70% solution 1.000 g sodium saccharinate 0.010 g aromatic agent q.s. water to 5.000 ml The above named components are mixed in a customary manner and filled in suitable drink vials having 5 ml content. d) Hard gelatin capsule tumor inhibitor 0.050 g nicotinamide 0.100 g microcristalline cellulose 0.150 g hydroxypropylcellulose 0.030 g mannite 0.100 g All components are mixed, moistened with granulation liquid and formed to pellets. The pellets can be filled in hard gelatin capsules either directly or after they after been provided with a functional coating. A capsule contains 50 mg tumor inhibitor and 100 mg nicotinamide. Through the multi- particulate medicinal pellets, the possibility also exists to fill differently coated pellets in a hard gelatin capsule. Two possibilities are to be particularly named. On the one hand, gastric fluid resistant pellets can be filled together with sustained action pellets. On the other hand, gastric fluid resistant pellets can also be combined with one or more other sorts of pellets or other working forms which release the active ingredient at different pH values of the surroundings . 101 Fundamentally, the possibility also exists for the combination of the tumor inhibitors in form of pellet plus nicotinamide in pellet form, if necessary, with different functional coatings, each combined in a hard gelatin capsule, 3.3 Topic administrable medicinal forms a) Gel tumor inhibitor 0.500 g nicotinic acid benzylester 1.500 g carbomer 1.000 g glycerin 10.000 g isopropanol 15.000 g hydrochloric acid, diluted q. s . sodium hydroxide solution q.s. water to 100.000 g The tumor inhibitor is dissolved in diluted hydrochloric acid and the nicotinic acid benzylester in isopropanol and water. Carbomer is dispersed in a portion of the water. Subsequently, all partial amounts are combined and the sodium hydroxide solution is added. b) Lipophilic salve tumor inhibitor 1.000 g nicotinamide 2.000 g propylene glycol 5.000 g paraffin, liquid 10.000 g paraffin wax 8.000 g vaseline o 100.000 g 102 The active ingredients are dissolved in propylene glycol at ca 60°C. Simultaneously the lipophilic components are melted at 60-70 °C and subsequently combined with the active ingredient solution. The salve is at first emulsified at 60- 70°C, then cooled to 35-40°C under continuous emulsification and filled. The nicotinamide (niacinamide) can also be replaced by another given vitamin PP compound or a compound effective as vitamin PP, for example in the form of nicotinic acid or its derivatives in these topically and/or locally or regionally appliable medicaments, optionally in the form of liquid compositions. The suitable dosage of the active ingredients can be adjusted depending on the particular pharmacokinetics, the responsiveness of patients as well as according to the appraisal of a doctor. D. Examples for medical forms with a sole amount of vitamin PP compounds for separate administration (next to the application of one or more cancerostatic agents) Preferably, these examples find their use according to the invention in the neutralization of sporadically existing, acute side-effects as a result of the chemotherapeutic application of cancerostatic agents, whereby dosages and/or dosage units of the vitamin PP compounds here can preferably be considered in the range of 1 000 mg to 10 000 mg nicotinamide. In the case of the use of other vitamin PP compounds, the dosaging among others of nicotinic acid can be correspondingly adjusted according to the appraisal of a doctor. 103 4.1 Injection therapeutic agents a) Parenteral solution nicotinamide 50.000 g water for injection purposes to 1000.000 ml The solution is produced according to customary method, sterlized and filled in 10 ml vials. A vial contains 500 mg nicotinamide . b) Parenteral solution nicotinamide 200.000 g waster for injection purposes to 1000.000 ml The solution is produced according to customary method, filled in 100 ml vials and sterilized. A vial contains 20 g nicotinamide. Since the solution is hypertonic, it must be suitably diluted before the application. 4.2 Peroral administrable medicament a) Tablets nicotinamide 10,000 g microcristalline cellulose 2, 600 g crospovidone 300 g talcum 600 g The above components are mixed with each other and compacted in a convention manner. The tablic weight amounts to 1350 mg. Each tablet contains 1000 mg nicotinamide. If desired, a gastric fluid-resistant or sustained action film-coating can also be applied in a known manner. 104 b) Vail for drinking nicotinamide 5.000 g Sorbite, 70 % solution 4.000 g sodium saccharinate 0.040 g aromatic agent q.s. water to 20.000 ml The above named components are mixed in a customary manner and filled in suitable drinking vials having 20 ml content. c) Hard gelatin capsule nicotinamide 0.500 g microcristalline cellulose 0.150 g hydroxypropylcellulose 0.030 g mannite 0.050 g All components are mixed, moistened with granulation liquid and formed to pellets. The pellets can be filled in hard gelatin capsules either directly or after they after been provided with a functional coating. A capsule contains 500 mg nicotinamide. Through the multi-particulate medicinal pellets, the possibility also exists to fill differently coated pellets in a hard gelatin capsule. Two possibilities are to be particularly named. On the one hand, gastric fluid resistant pellets can be filled together with sustained action pellets. On the other hand, gastric fluid resistant pellets can also be combined with one or more other sorts of pellets or other working forms which release the active ingredient at different pH values of the surroundings. 4.3 Inhalation therapeutics 105 a) Dry powder dosage formulation mg/Doses nicotinamide 10.0 mg lactose 5.0 mg The active ingredients are formulated to small pellets with lactose after micronization, subsequently filled in hard gelatin capsules and placed in a single-dosage-powder applicator for use. E . Combination of different tumor inhibitors and/or cytostatic agents or cancerostatic agents with the vitamin PP compounds As already mentioned above, further cancerostatic agents, optionally as sole cytostatic agents or immunosuppressive agents for example in the form of the following compounds or compound groups can be formulated, in addition to the anti- tumor compounds especially those of the general formula (I) into the above given examples for the use of the vitamin PP compounds according to the invention and/or the combinations according to the invention with an amount of these compounds: Alkylizing, cytostatic agents (alkylanizers) , for example, derivatives without nitrogen such as cyclophosphamide, trofosfamide, ifosfamide, melphalane, mechloroethamine, chlorambucil as well as ethylenimine derivatives (aziridines) such as thiotepa; further alkylizing compound would be for example busulfane; additionally, among these exemplified alkylating cytostatic agents are carmustine, lomustine or nimustine, which can be considered in a wider sense as belonging to this compound group of alkylanizers as N- nitroso-urea derivatives; procarbazine and dacarbazine are also mentioned as belonging to this series; diaziquone, 106 hexamethylmelamine, trimelamole or temozolamide are also referred to with respect to the group of alkanizers. Examples for cancerostatic anti-metabolites are folic acid antagonists, such as methotrexate, edatrexate, trimetrexate or its ethyl derivative 10-ethyl-lO-desaza-aminopterine as well as purine and pyrimidine base antagonists or antagonists with other points of attack, for example, 6-mercaptopurine and 6-thioguanine, 5-fluorouracil, floxuridine, ara-c, hydroxyurea, desoxycoformycine, triazofurine, acivicine, PALA, pyrazofurine as well as cytarabine, vidarabine, fludarabine, desoxycoformycine, 2-chloro-2 '-desoxy-adenosine or tiazofurine. In this connection, various IFN compounds, IL2 or leucovorine are particularly considered as synergists. A further important group of cancerostatic agents are represented by the platinum complexes such as cisplatin and carboplatin. Podophyllotoxins or epipodophyllotoxins as antimitotic agents such as etoposide or teniposide have achieved certain importance as cancerostatic agents. This is true in a similar manner for vinca alkaloids, for example vinblastin, vincristin, vindesin, navelbin or 17- desacetylvinblastin. Cytostatically effective antibiotics capable of being combined are also considered in connection with the invention such as, for example, actinomycins, such as dactinomycin or actinomycin D, anthracyclines such as daunorubicin, doxorubicin, rubidazone, detorubicin, epirubicin, carminomycin, aclacinomycin A, marcellomycin, AD-32, THP- doxorubicin, esorubicin, idarubicin, menogaril, or mitoxantrone or bleomycin as well as mitomycin C with comparable antibiotic effects. Morpholinyl derivatives with 107 the name MRA, MRA-MO, MRA-CN or MRD-nr-CN or the morpholinyl anthracycline derivative MX2 also belong to these. The series of the cancerostatic agents from different compound groups can be extended with newer compounds such as L-alanosine, amonafide, amsacrine, mafosfamide, bisantrene, carbethimer, desoxyspergualine, α-difluoromethylornithine, mitolactol, didemnine B, echinomycin, ellipticiniumacetate, gallium nitrate, optionally, cimetidine or retinoids, homoharringtonine, razoxane, indicin-N-oxide, lonidamine, menogaril, mitiguazone, N-methylformamide, mitozolamide, piritrexime, spirogermanium, spiromustin, suramin, taxol, taxoter, teroxirone, hydroxyurea, 1, 2, -triglycidylurazole, 1-asparaginase, lentinane, vinzolidine or radioactive isotopes such as 32 P, 90 Y, 211 At or 131 I, whcih can each be coupled to an antibody for targeting purposes. An important group of cancerostatic agents are represented by hormonal compounds, i.e. hormones themselves such as androgens/anti-androgens, glucocorticoids or estrogens/anti- estrogens, depot estrogens, gestagens as well as hormone antagonists/hypothalamus hormones, estrogen receptor antagonists or aromatase inhibitors. Among others, examples of compounds of this type are mentioned in the following: busereline, gosereline, leuproreline, triptoreline, such as for example, stilbestrol, diethylstilbestrol, megestrol (acetate) , diethyl-stilbestrol diphosphate, estradiol (undecylate) , gonadoliberine, fosfestrol, estramustine, tamoxifene, drostanolone (propionate) , fluoxymesterone, testolactone, aminoglutethimide, mitotane, medroxiprogesterone (acetate) flutamide, megestrol (acetate) , aminoglutethimide, 4-hydroxyandrostendione, plumestane, exe estane, pyridoglutethimide, fadrazole, arimidex, vorazole, flutamide, cyproterone, mifepristone, hydroxyprogesterone, progesterone or ethinylestradiol, 108 For immunosuppressive therapies cyclosporin can be used for example, whereby corticosteroids, such as for example, prednisone or methylprednisolol as well as methotrexate and azathioprine or cyclophosphamide can also be applied. A known combination of immunsuppressive agents of this type is the combined use of cyclosporine or prednisone together with azathioprine. Included in the series of the above customary, exemplified cancerostatic agents as well as cancerostatic agents not named here are pharmacolgically acceptable salts, esters, ethers, optic isomers, stereoisomers and other analogously effective derivatives depending on their structure. The preferred single doses of the cancerostatic agents and/or immunosupressive agents are oriented in accordance with customary therapeutic recommendations given in the literature and company information. Depending on effectiveness and the therapeutic spectrum of the cytcostatic agents, they range for example from 0,1 mg up to 10 000 mg. Expressed in absolute dosage units, the unit doses can be 0.1, 0.2, 0.5, 1, 2, 5, 10, 20, 50, 75, 100, 150, 200, 300, 400, 500, 600, 750, 800, 900, 1000, in individual cases up to 1 200, 1 500, 2 000, 5 000 or 10 000 mg . In the case of the use of interferon compounds, the administered dosage amounts expressed in units are for example 1, 2, 3, 4, 5, 10, 15, 20, 25, 30 40 or 50 million units. This is also true in a similar manner for cancerostatic enzymes, such as for example, asparaginases, which can be administered in an amount of 1000, 6000 or 10 000 units per m 2 body surface. The given dosage units also extend to the application of pyridylcarboxamide compounds according to the general formula (I), which can lie in the range between 0.1 mg, 1, 10 mg up to 5000 or 10 000 mg individual doses as discussed above. 109 Depending on the existence of a synergistic, super-additive effect combination of two or more cancerostatic agents, the customary dosages can also be reduced. Therewith, the side- effects associated with the administration of cancerostatic agents can be further reduced. Conversely, if need be, considerably higher dose of cancerostatic agents can be administered without danger for patients in the case that the vitamin PP compounds reduce the side-effects in accordance with the invention. The above discussion of the respective suitable cancerostatic agents merely has an exemplifying character and no limiting character in any way because it cannot be complete as a result of the incalculable abundance of known medicaments; further customary cancerostatic agents and carrier systems for this are to be taken from relevant handbooks such as for example M.Peckham, H.Pinedo and U. Veronesi: Oxford Textbook of Oncology Vol. 1 & Vol. 2, Oxford University Press, Oxford, New York, Tokyo (1995) or W. Forth, D.Henschler, W. Rummel, , K.Starke: General and specific pharmacology, SPEKTRUM, Heidelberg, Berlin Oxford, 7. Edition (1996) or E. Mutschler: Medicament activities, textbook of pharmacology & toxicology, WVG, Stuttgart, 6. Edition (1991) or other compendia and the remaining literature or the art on anti-tumor agents. 1 10 PHARMACOLOGICALL - EXPERIMENTAL PORTION In the following examples, an anti-tumor substance was used which was synthesized by Klinge Pharma GmbH under the label K22.097 and is described in the publication PCT/EP97/03243=WO97/48695 as substance Nr.54 (production example 4 in the form of N- [4- ( l-diphenylmethylpiperidin-4- yl ) -butyl ] -3- (pyridin-3-yl ) -propionamide . 1. Neutralization of the growth-inhibiting effect of anti- tumor substances by nicotinic acid and nicotinamide in human leukaemia cells. THP-1 cells derived from a human monocytic leukaemia plated at a density of 200,000 cells/ml in 96-well plastic dishes. Cultivation occurred in RPMI 1640 nutrient medium with 10% foetal calf serum (FCS) in a tissue culture incubator with a gas mixture of 5% C0 2 and 95% air at a temperature of 37°C. For the individual concentrations and the controls without test substances as well as for the background with nutrient medium but without cells, three-fold batches were done for each. After four days of substance incubation 20 μl WST-1 reagent (Boehringer Mannheim) was respectfully pipetted in each individual well. After 30 to 60 minute incubation in the tissue culture incubator at 37°C and 5% CO2 , the light extinction was measured in an ELISA reader at 450 nm wave length. The backgrounds were each subtracted from the typical measured valves. (The IC 5 o-values (defined as that concentration in which the cell growth was inhibited by 50%) was taken from the dose-response curves and given as a comparative measurement for the activity of the test compounds . 111 The measured values obtained in this manner are given in the following Table 1: Test substances ICso-Value for K22.097 K22.097 alone 0, 01 μM K22.097 + 0, 1 mM > 10 μM nicotinic acid K22.097 + 1 mM > 10 μM nicotinamide Table 1 As can be seen from Table 1, the growth-inhibiting effect of K22.097 is abrogated by nicotinic acid as well as by nicotinamide. 2. Neutralization of the growth- inhibiting effect of anti- tumor substances by nicotinic acid and nicotinamide in normal lymphocytes Many cytostatic agents and radiation therapies as well have a cytcotoxic effect not only on tumor cells but also on the blood cell system. This leads to a weakening of the immune defence which can lead to life threatening infections. In addition, this can result in a so-called tumor lyse syndrome which can lead to the death of the patient by the relatively quick death of large cell masses. In order to test the possibility for a therapeutical use of nicotinic acid and/or nicotinamide for preventing such life threatening conditions by massive cell death, the effect of the substance was tested on freshly isolated lymphocytes as follows: 112 The spleen of a Swiss mouse served as a lymphocyte source. The lymphocyte population was isolated from the spleen cell suspension over a ficoll gradient and taken up in IMEM-ZO culture medium with 0,1% dextran 70,000 and 2% foetal calf serum. The cells were plated at a density of ca . 500,000 cells/well/ml in a 12-well plate, 1 ml doubly concentrated test substance solution was pipetted per well and this was subsequently incubated in a tissue culture incubator at 37°C and 5% C0 2 . After 2 days, a 1 ml-aliquot with 5 μl of the fluorescent dye solutions propidium iodide (8 mg/ml) and 3, 3 ' -dihexyloxacarbocyanin iodide (40 μg/ml) each was added per well, and incubated for 3 minutes at room temperature. Subsequently, 10,000 cells per each sample were measured on a flow-through cytometer and the percentage amount of vital cells in the population was determined. By means of the dose- response curves, IC 5 o-values were calculated which were also employed in the following Tables for the characterization of the individual substances : Test substances ICso-Value for K22.097 K22.097 alone 0, 001 μM K22.097 + 10 mM > 1 μM nicotinamide Table 2 3. Neutralization of growth- inhibiting effect of anti-tumor substances by nicotinic acid in nicotinamide in primary intestine cells. Cryptic cells of the large intestine were isolated according to the method of Booth et al . (1995) with slight modifications. The removed large intestine was cut into pieces, the parts were finally cut after several-fold washing 1 13 and digested with collagenase and dispase. Subsequently, the larger tissue pieces remaining in the suspension were sedimented, the supernatant was decanted and stored. The pellet was digested again under vigorous shaking with medium in order to release additional cryptic cells. After sedimentation, the supernatant was poured off again, combined with the first fraction and the cryptic cells were centrifuged at 50 * g. After a further washing step, the centrifuge cryptic cells were suspended in culture medium and seeded at a density of 800 cells per well in 24-well-cultured dishes which were previously coated with collagen. The cells were incubated at 37 °C in a saturated water vapour atmosphere with 92.5% air and 7.5% C0 2 . 50% of the nutrient medium was renewed every two days. The test substances were added 48 hours after the plating of the cryptic cells; the treatment with them lasted a total of 4 days. The growth of the culture was photometrically quantified after staining with crystal violet as a measure for the cell number and the vitality of the cells was determined with the MTT-test whose reaction depends on living cells with active mitochondria. Based on dose response curves, the IC 50 -values were calculated which are also used in the following Table 3 for characteization of the individual substance activity: 114 Test substances ICso-Value for K22.097 K22.097 alone 0,1 μM K22.097 + 1 mM > 10 μM nicotinamide Table 3 4 . Neutralization of the toxic effect of anti-tumor substances by nicotinamide in NMRI Mice Groups of 6 mice each were treated over 4 days with different doses of the anti-tumor substance K22.097 orally administered twice daily. Parallel to this, 500 g/kg nicotinamide was simultaneously intraperitoneally administered each to the individual dosage groups. 7 days after the beginning of treatment, the blood picture of the individual animals was examined. The results are summarized in following Table 4: Test substances Mortality Leukocyte number 0,5% carboxymethylcellulose 0 / 6 5, 100 per μl (control) 2x100 mg/kg K22.097 1 / 6 1, 100 per μl 2x120 mg/kg K22.097 3 / 6 500 per μl 2 χ 500 mg/kg nicotinamide 0 / 6 4, 800 per μl 2x100 mg/kg K22.097 + 0 / 6 6, 900 per μl 2 χ 500 mg/kg nicotinamide 2x120 mg/kg K22.097 + 0 / 6 5, 900 per μl 2 χ 500 mg/kg nicotinamide Table 4 1 15 The results of Table 4 show that the cases of death caused by the anti-tumor substance as well as the strong reduction of leucocyte cells could be completely prevented. It is evident from the experimental results represented in Tables 1 - 4 that the use of compounds of the vitamin PP group according to the invention is capable of suppressing the unavoidable side-effects of anti-tumor substances or is at least capable of elevating these and/or neutralizing the cancerostatic activity in a surprising manner in unexpected threatening incidents. This result was not to be expected in view of the known, sensitivity-increasing and effect- increasing activities of nicotinic acid and/or its amide discussed at the beginning. As already discussed in the above mentioned publications and also the older patent applications of the applicant not yet published at the present application date, the tumorstatic agents according to the general formula (I) are especially suitable also in connection with the invention subject matter described herein, preferably in the chemotherapy of malignant diseases of humans and animals. The anti-neoplastic effect of the described substances of formula (I) can be used for prophylactic, adjuvant, palliative and curative treatment of solid tumors, leukeamic diseases and lymphomas, as well as for reducing or preventing metastases formation in humans and animals. The therapeutic use is possible in the following illnesses for example: gynaecological tumors, ovarian carcinomas, testicle tumors, prostate carcinomas, skin cancer, kidney cancer, bladder tumors, oesophagus carcinomas, stomach cancer, rectal carcinomas, pancreas carcinomas, thyroid cancer, adrenal tumors, leukaemia and lymphomas, Hodgkin's disease, tumor illnesses of the CNS, soft-tissue sarcomas, bone sarcomas, benign and malignant mesotheliomas, but especially intestine cancer, liver cancer, breast cancer, bronchial and lung carcinomas, melanomas, acute and chronic 1 16 leukaemias . Benign papillomatosis tumors can also be limited in their growth with the named substances . The use according to the invention and the medicaments according to the invention for neutralization of acute side- effects or reduction of side-effects can also be performed with these substances according to general formula (I) in tumors which are resistant against customary cytostatic agents. In addition, as already mentioned above, combinations of these tumor inhibitors with other known pharmaceutical agents which are used in chemotherapy are promising due to their independent characteristics as long as their properties are complemented in a suitable manner. The integration of these pyridylcarboxamides in a therapy scheme can be particularly successful for example with one or more substances from the following classes: anti-metabolites (for example cytarabine, 5-fluorouracil, 6- mercaptopurine, methotrexate) , alkylating agents (for example busulfane, carmustine, cisplatin, carboplatin, cyclophosphamide, dacarbazine, melphalane, thiotepa) , DNA- intercalating substances and topoisomerase inhibitors (for example actinomycin D, daunorubicin, doxorubicin, mitomycin C, mitoxantrone, etoposide, teniposide, topotecane, irinotecane) , spindle poisons (for example vincristine, navelbine, taxol, taxoter) , hormonally active agents (for example tamoxifene, flutamide, formestane, gosereline) or other cytostatic agents with complex modes of action (for example L-asparaginase, bleomycin, hydroxyurea) . Resistant tumor cells can be made sensitive again for example by interaction of the new compounds with a mechanism of resistance for common cytostatic agents (for example P- glycoprotein, MRP, glutathione-S-transferase, metallothionein) . 117 Many anti-tumor agents have not only a cytotoxic effect on tumor cells, but also on the blood cell system. This leads to a weakening of the immune defence, which can, in turn, be specifically employed to suppress the rejection reaction after an organ transplantation for example. The use in immunological disease such as for example psoriasis or autoimmune diseases is therefore also possible. Hence, the independent structural class of the preferred compounds from the group of substituted 3-pyridylcarboxyl amides also makes possible a combination with other known immunosuppressive agents such as for example, cyclosporine A, tacrolimus, rapamycin, azathioprine and glucocorticoids . Furthermore, the anti-tumor substance Nr.159 with the internal label K22.175 according to the publication PCT/ EP97/03245=WO97/48696 in the form of N- [4- (1-benzoylpiperi- din-4-yl) -butyl] -3- (pyridin-3-yl) -acrylamide synthesized by the applicant was included in the experimental examinations. The results obtained therefrom confirm the above described finding on the useful effect according to the invention of the vitamin PP compounds. The results corresponding to the method used in Example 1, Table 1, are given in Table 5 as follows : Test substances ICso-Value for K22.175 K22.175 alone 0.5 nM K22.175 + 0.1 mM > 30 nM nicotinic acid K22.175 + 1 mM > 30 nM nicotinamide Table 5 1 18 As already mentioned at the beginning, the use according to the invention and the medicaments produced and applied according to the invention also relate to the combination of cancerostatic chemotherapy with radiation and/or radiotherapy, whereby hypothermia as a heat irradiation treatment or other physical tumor therapies are included within the invention.

Claims: 1 1 9 CLAIMS 1. Use of compounds with vitamin PP activity as cytoprotective agents for prevention, reduction, or elimination of less severe or acute side effects and/or neutralization of the effect of cancertostatic agents or immunosuppressive agents, especially compounds from the series of substituted pyridylalkane, pyridylalkene and pyridylalkine acid amides, in diagnosis or cytostatic or immunosuppressive chemotherapy, anti-proliferative and metastasis formation-preventative or prophylactic therapy or the control of immune reactions such as autoimmune diseases, optionally in combination with radiation therapy. 2. Use according to claim 1, characterized in that nicotinic acid or nicotinamide and/or their pharmocologically and pharmaceutically acceptable ester or amide derivatives, anionic or quarternary salts or addition salts, N-oxides, optionally their analogous thioxo derivatives, optionally their isomers as well as their prodrugs, are used as a compound or compounds with vitamin PP activity, and pyridylalkane, pyridylalkene and pyridylalkine acid amides of the following general formula (I) R3(i) .0 ) β) -N R 1( ^SC~ R4(») N (0) k ( i : 120 are used as cancerostatic agents and/or tumor inhibitors or immuosuppressive agents, wherein the residues R^- ), R 2 ('), R 3 w and R4(A) are selected from halogen, hydroxy, trifluoromethyl, cyano, aliphatic hydrocarbon residues, optionally substituted with functional groups, optionally interrupted by one or more hetero-atoms, or aromatic hydrocarbon residues, whereby, R 1 ) and R2( can form a bridge together, k is the number 0 or 1, and A( and Dv 1 ) signify an aliphatic, saturated or unsaturated, optionally substituted, hydrocarbon residue which can optionally be interrupted by a hetero-atom or a functional group, E is a bond or a heterocycle with either one or two N-atoms or an N-atom plus an O-atom, whereby their linkage with Dv 1 ) and G either occurs over a nitrogen atom and a carbon atom or optionally over both ring nitrogen atoms; G is selected from hydrogen or an aliphatic or araliphatic residue, an unsaturated or aromatic, mono- or polycyclic carbocyclic residue, a saturated, unsaturated or aromatic, mono- or polycyclic heterocyclic residue, which can be bound directly or over a functional group, derived from C-, N-, 0-, S- or P-atoms, for example, an ether, thioether, acyl, sulfonyl, phosphinoyl group, or an amide, carbamate, ureide, sulfonamide or phosphinamide group, or a mono- or polycyclic imide bound over the imide nitrogen atom, as well as their 121 stereoisomers including cis/trans-isomers, E/Z-isomers, enantiomers, as well as diastereomers and other isomers of the above defined compounds, in optionally pure form or as their racemic and/or non-racemic mixtures; as well as the tautomers of the above defined compounds, in the optional case that G represents a heterocyclic aromatic ring or one which contains simultaneous substitution by free hydroxy, mercapto or amino groups; and the corresponding pharmacologically acceptable acid addition salts of the above defined compounds. 3. Use according to claim 1 or 2, characterized in that the pyridylalkane, pyridylalkene and pyridylalkines acid amides of the general formula (I) concern the following compounds: N- [2- (l-benzylpiperidin-4-yl) -ethyl] -3- (pyridin-3-yl) - propionamide; N-{2- [1- (2-phenylethyl) -piperidin-4-yl] -ethyl }-3- (pyridin-3- yl) -propionamide; N-{2- [1- (4-phenylbutyl) -piperidin-4-yl] -ethyl} -3- (pyridin-3- yl) -propionamide; N-{2- [1- (4-hydroxy-4-phenylbutyl) -piperidin-4-yl] -ethyl} -3- (pyridin-3-yl) -propionamide; N- [2- (l-diphenylmethylpiperidin-4-yl) -ethyl] -3- (pyridin-3- yl) -propionamide, N- [3- (l-diphenylmethylpiperidin-4-yl) -propyl] -3- (pyridin-3- yl ) -propionamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3- (pyridin-3- yl) -propionamide; 122 N- [4- (l-benzylpiperidin-4-yl) -butyl] -3- (pyridin-3-yl) - acrylamide; N-{4- [1- (2-phenylethyl) -piperidin-4-yl] -butyl}-3- (pyridin-3- yl) -acrylamide; N-{4- [1- (4-biphenylylmethyl) -piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -acrylamide; N-{4- [1- (1-naphthylmethyl) -piperidin-4-yl] -butyl} -3- (pyridin- 3-yl) -acrylamide; N- { 4- [ 1- ( 9-anthrylmethyl ) -piperidin-4-yl ] -butyl } -3- (pyridin- 3-yl) -acrylamide; N-{4- [1- (cyclohexylphenylmethyl) -piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -acrylamide; N- {4- [1- (10, ll-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) - piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -acrylamide; N- [2- (l-diphenylmethylpiperidin-4-yl) -ethyl] -3- (pyridin-3- yl) -acrylamide; N- [3- (l-diphenylmethylpiperidin-4-yl) -propyl] -3- (pyridin-3- yl) -acrylamide; N- [5- (l-diphenylmethylpiperidin-4-yl) -pentyl] -3- (pyridin-3- yl) -acrylamide; N- [ 6- ( l-diphenylmethylpiperidin-4-yl) -hexyl] -3- (pyridin-3- yl) -acrylamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -5- (pyridin-3- yl) -2, 4-pentadienic acid amide; N- (4- { 1- [bis- (4-fluorophenyl) -methyl] -piperidin-4-yl }-butyl) - 3- (pyridin-3-yl) -acrylamide; N- (4-{ 1- [bis- (2-chlorophenyl) -methyl] -piperidin-4-yl} -butyl) - 3- (pyridin-3-yl) -acrylamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3- (2-fluoro- pyridin-3-yl) -acrylamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3- (6-fluoro- pyridin-3-yl) -acrylamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3- (pyridin-3- yl) -acrylamide; 123 N- [4- ( l-diphenylmethylpiperidin-4-yl) -butyl] -3- (pyridin-3- yl) -acrylamide»dihydrochloride or N- [ 4- ( l-diphenylmethylpiperidin-4-yl ) -butyl ] -3- (pyridin-3- yl) -acrylamide»methanesulfonate; N- [4- (l-acetyl-piperidin-4-yl) -butyl] -3- (pyridin-3-yl) - propionamide ; N- [4- (l-benzoyl-piperidin-4-yl) -butyl] -3- (pyridin-3-yl) - propionamide; N- [4- (l-diphenylacetyl-piperidin-4-yl) -butyl] -3- (pyridin-3- yl) -propionamide; N- {4- [1- (9-oxo-9H-fluoroen-4-carbonyl) -piperidin-4-yl] - butyl }-3- (pyridin-3-yl) -propionamide; N- [4- (l-methylsulfonyl-piperidin-4-yl) -butyl] -3- (pyridin-3- yl) -propionamide; N-{4- [1- (2-naphthyl-sulfonyl) -piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -propionamide; N- [4- (l-benzyl-piperidin-4-yl) -butyl] -3- (pyridin-3-yl) - propionamide ; N- (4- { 1- [bis- (2-chlorophenyl) -methyl] -piperidin-4-yl}-butyl) - 3- (pyridin-3-yl) -propionamide; N-{4- [1- (phenylpyridin-3-yl-methyl) -piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -propionamide; N-{4- [1- (9H-fluoroen-9-yl) -piperidin-4-yl] -butyl} -3- (pyridin- 3-yl) -propionamide; N-{4- [1- (6, 11-dihydrodibenzo [b, e] oxepin-11-yl) -piperidin-4- yl] -butyl}-3- (pyridin-3-yl) -propionamide; N-{4- [1- (1-naphthylamino-carbonyl) -piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -propionamide; N- [4- ( l-diphenylamino-carbonyl-piperidin-4-yl) -butyl] -3- (pyridin-3-yl) -propionamide; N- { 4- [1- (10, 11-dihydro-dibenzo [b, f] azepin-5-yl-carbonyl) - piperidin-4-yl] -butyl }-3- (pyridin-3-yl) -propionamide; 124 N- [4- (l-Diphenylphosphinoyl-piperidin-4-yl) -butyl] -3- (pyridin-3-yl) -propionamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3- (2-fluoro- pyridin-3-yl) -propionamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3- (5-fluoro- pyridin-3-yl) -propionamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -2-fluoro-3- (pyridin-3-yl) -propionamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -2, 2-difluoro-3- (pyridin-3-yl) -propionamide; N- [5- (l-diphenylmethylpiperidin-4-yl) -pentyl] -3- (pyridin-3- yl) -propionamide; N- [6- (l-diphenylmethylpiperidin-4-yl) -hexyl] -3- (pyridin-3- yl) -propionamide; N- [2- (l-diphenylmethylpiperidin-4-yl) -ethyl] -5- (pyridin-3- yl) -pentanoic acid amide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -5- (pyridin-3- yl) -pentanoic acid amide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -N-hydroxy-3- (pyridin-3-yl) -propionamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -2-hydroxy-3- (pyridin-3-yl) -propionamide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3-hydroxy-3- (pyridin-3-yl) -propionamide and N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -3- (pyridin-3- yl) -propionamide; N- [4- (l-methylsulfonylpiperidin-4-yl) -butyl] -3- (pyridin-3- yl) -acrylamide; N-{4- [1- (2-naphthylsulfonyl) -piperidin-4-yl] -butyl}-3- (pyridin-3-yl) -acrylamide; N-{4- [1- (2-naphthylsulfonyl) -piperidin-4-yl] -butyl}-5- (pyridin-3-yl) -2, 4-pentadienic acid amide; 125 N-{4- [1- (1-naphthylaminocarbonyl) -piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -acrylamide; N- [4- (l-diphenylaminocarbonylpiperidin-4-yl) -butyl] -3- (pyridin-3-yl) -acrylamide; N- [ - ( l-diphenylaminocarbonyl-piperidin-4-yl ) -butyl ] -5- (pyridin-3-yl) -2, 4-pentadienic acid amide; N- { 4- [1- (10, 11-dihydrodibenzo [b, f] azepin-5-yl-carbonyl) - piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -acrylamide; N- [4- (l-Diphenylphosphinoyl-piperidin-4-yl) -butyl] -3- (pyridin-3-yl) -acrylamide; N- [4- (l-acetylpiperidin-4-yl) -butyl] -3- (pyridin-3-yl) - acrylamide; N- [4- (l-diphenylacetylpiperidin-4-yl) -butyl] -3- (pyridin-3- yl) -acrylamide; N-{4- [1- (3, 3-diphenylpropionyl) -piperidin-4-yl] -butyl }-3- (pyridin-3-yl) -acrylamide; N- [4- (l-benzoylpiperidin-4-yl) -butyl] -3- (pyridin-3-yl) - acrylamide; N- [4- (l-benzoylpiperidin-4-yl) -butyl] -5- (pyridin-3-yl) -2,4- pentadienic acid amide; N-{4- [1- (9-oxo-9H-fluoren-4-yl-carbonyl) -piperidin-4-yl] - butyl }-3- (pyridin-3-yl) -acrylamide; N- { 4- [1- (phenylpyridin-3-yl-methyl) -piperidin-4-yl] -butyl} -3- (pyridin-3-yl) -acrylamide; N- {4- [1- (phenylpyridin-4-yl-methyl) -piperidin-4-yl] -butyl }-3- (pyridin-3-yl) -acrylamide; N-(4- [1- (6, 11-dihydrodibenzo [b, e] oxepin-11-yl) -piperidin-4- yl] -butyl}-3- (pyridin-3-yl) -acrylamide; N- { 4- [1- ( 6, 11-dihydrodibenzo [b, e] thiepin-11-yl) -piperidin-4- yl] -butyl }-3- (pyridin-3-yl) -acrylamide; N- [7- (l-diphenylmethylpiperidin-4-yl) -heptyl] -3- (pyridin-3- yl) -acrylamide; N- [8- (l-diphenylmethylpiperidin-4-yl) -octyl] -3- (pyridin-3- yl) -acrylamide; 126 N- [3- (l-diphenylmethylpiperidin-4-yloxy) -propyl] -3- (pyridin- 3-yl) -acrylamide; N- [3- (l-benzylpiperidin-4-yloxy) -propyl] -3- (pyridin-3-yl) - acrylamide; N- [2- (l-diphenylmethylpiperidin-4-yl) -ethyl] -5- (pyridin-3- yl) -2, 4-pentadienic acid amide; N- [4- (l-diphenylmethylpiperidin-4-yl) -butyl] -5- (pyridin-3- yl) -2, 4-pentadienic acid amide; N- [ 5- ( l-diphenylmethylpiperidin-4-yl ) -pentyl ] -5- (pyridin-3- yl)-2,4- pentadienic acid amide; or N- [6- (l-diphenylmethylpiperidin-4-yl) -hexyl] -5- (pyridin-3- yl)-2,4- pentadienic acid amide; N- [4- (4-diphenylmethylpiperazin-l-yl) -3-hydroxy-butyl] -3- pyridin-3-yl-acrylamide; N- [3- (4-diphenylmethylpiperazin-l-yl) -propoxy] -3-pyridin-3- yl-acrylamide; N- [4- (4-diphenylmethylpiperazin-l-yl) -4-oxo-butyl] -3-pyridin- 3-yl-acrylamide; N- [3- (4-diphenylmethylpiperazin-l-sulfonyl) -propyl] -3- pyridin-3-yl-acrylamide; N-{2- [2- (4-diphenylmethylpiperazin-l-yl) -ethoxy] -ethyl }-3- pyridin-3-yl-acrylamide; N- (4- { 4- [bis- (4-fluorophenyl) -methyl] -piperazin-1-yl }-but-2- inyl) -3-pyridin-3-yl-acrylamide; N- { 4- [4- (4-carboxyphenyl-phenylmethyl) -piperazin-1-yl] - butyl }-3-pyridin-3-yl-acrylamide; N- (4-{4- [ (4-aminophenyl) -phenylmethyl] -piperazin-1-yl }- butyl) -3-pyridin-3-yl-acrylamide; N-{4- [4- (9H-fluoroen-9-yl) -piperazin-1-yl] -butyl} -2- (pyridin- 3-yloxy) -acetamide; N-(5- [4- (9H-fluoroen-9-yl) -piperazin-1-yl] -pentyl }-3-pyridin- 3-yl-acrylamide; 127 N- { 6- [4- (9H-fluoroen-9-yl) -piperazin-1-yl] -hexyl } -3-pyridin- 3-yl-acrylamide; 3-pyridin-3-yl-N-{4- [4- (1,2,3, 4-tetrahydronaphthalin-l-yl ) - piperazin-1-yl] -butyl} -acrylamide; 3- pyridin-3-yl-N-{4- [4- (5, 6,7, 8-tetrahydronaphthalin-l-yl) - piperazin-1-yl] -butyl } -acrylamide; N- {4- [4- (naphthalin-1-yl) -piperazin-1-yl] -butyl } -3-pyridin-3- yl-acrylamide; N- [4- (4-biphenyl-2-yl-piperazin-l-yl) -butyl] -3-pyridin-3-yl- propionamide; N- [5- (4-biphenyl-2-yl-piperazin-l-yl) -pentyl] -3-pyridin-3-yl- acrylamide; N- [ 6- (4-biphenyl-2-yl-piperazin-l-yl) -hexyl] -3-pyridin-3-yl- acrylamide; N- [4- (4-biphenyl-2-yl-piperazin-l-ly) -butyl] -2- (pyridin-3- yloxy) -acetamide; N- [4- (4-biphenyl-2-yl-piperazin-l-yl) -butyl] -5- (pyridin-3- yl) -penta-2, 4-dienic acid amide; N-{4- [4- (10, ll-dihydro-5H-dibenzo [a,d] cyclohepten-5-yl) - piperazin-1-yl] -butyl } -3-pyridin-3-yl-propionamide; N-{5- [4- (10, ll-dihydro-5H-dibenzo [a,d] cyclohepten-5-yl) - piperazin-1-yl] -pentyl }-3-pyridin-3-yl-acrylamide; N-{6- [4- (10, ll-dihydro-5H-dibenzo [a,d] cyclohepten-5-yl) - piperazin-1-yl] -hexyl }-3-pyridin-3-yl-acrylamide; N-{4- [4- (10, ll-dihydro-5H-dibenzo [a,d] cyclohepten-5-yl) - piperazin-1-yl] -butyl} -5- (pyridin-3-yl) -penta-2, 4-dienic acid amide; N-{4- [4- (6, 11-dihydro-dibenzo [b, e] oxepin-11-yl) -piperazin-1- yl] -butyl-3-pyridin-3-yl-propionamide; N-{2- [4- (6, 11-dihydro-dibenzo [b, e] thiepin-11-yl) -piperazin-1- yl] -ethyl }-3-pyridin-3-yl-acrylamide; N- [4- (4-diphenylacetylpiperazin-l-yl) -butyl] -3-pyridin-3-yl- acrylamide; 128 N- [4- (4-benzoylpiperazin-l-yl) -butyl] -3-pyridin-3-yl- acrylamide; N-{4- [4- (2-aminobenzoyl) -piperazin-1-yl] -butyl }-3-pyridin-3- yl-acrylamide; N- { 4- [4- (4-carboxybenzoyl) -piperazin-1-yl] -butyl }-3-pyridin- 3-yl-acrylamide; N- {4- [4- (biphenyl-2-carbonyl) -piperazin-1-yl] -butyl } -3- pyridin-3-yl-acrylamide; N- { 4- [4- (9-oxo-9H-fluoroen-4-carbonyl) -piperazin-1-yl] - butyl}-3-pyridin-3-yl-acrylamide; N-{4- [4- (furan-2-carbonyl) -piperazin-1-yl] -butyl }-3-pyridin- 3-yl-acrylamide; N- {4- [4- (naphthalin-1-yl-aminocarbonyl) -piperazin-1-yl] - butyl }-3-pyridin-3-yl-propionamide; N-{4- [4- (diphenylaminocarbonyl) -piperazin-1-yl] -butyl } -3- pyridin-3-yl-acrylamide; N-{4- [4- (naphthalin-2-sulfonyl) -piperazin-1-yl] -butyl} -3- pyridin-3-yl-acrylamide; N- [4- (4-diphenylphosphinonyl-piperazin-l-yl) -butyl] -3- pyridin-3-yl-acrylamide; N- [4- (4-biphenyl-2-yl-piperazin-l-yl) -butyl] -3-pyridin-3-yl- acrylamide; N-{4- [4- (9H-fluoroen-9-yl) -piperazin-1-yl] -butyl }-3-pyridin- 3-yl-acrylamide as well as N-{4- [4- (10, ll-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl) - piperazin-1-yl] -butyl }-3-pyridin-3-yl-acrylamide; N- [4- (4-phenylpiperidin-l-yl) -butyl] -3-pyridin-3-yl- acrylamide; N-{4-[4- (lH-indol-3-yl)-piperidin-l-yl] -butyl }-3-pyridin-3- yl-acrylamide; N- { 4- [4- (2-oxo-2, 3-dihydrobenzimidazol-l-yl) -piperidin-1-yl] butyl }-3-pyridin-3-yl-acrylamide; 129 N- [4- (4-benzotriazol-l-yl-piperidin-l-yl) -butyl] -3-pyridin-3- yl-acrylamide ; N- { 4- [4- (hydroxy-diphenylmethyl) -piperidin-1-yl] -butyl } -2- (pyridin-3-yloxy) -acetamide; N- [4- (4, 4-diphenylpiperidin-l-yl) -butyl] -3-pyridin-3-yl- acrylamide; N- { 4- [4- ( 6, 11-dihydrodibenzo [b, e] thiepin-11-yliden) - piperidin-1-yl] -butyl }-3-pyridin-3- ylpropionamide«dihydrochloride/ semi-isopropanol; N-{4- [4- (6, 11-dihydrodibenzo [b, e] thiepin-11-yliden) - piperidin-1-yl] -butyl }-5-pyridin-3-yl-pentanamide; N-{4- [4- (4, 9-dihydro-thieno [2, 3-b] -benzo [e] thiepin-4-yliden) - piperidin-1-yl] -butyl }-3-pyridin-3-yl-propionamide; N- { 4- [4- (4, 9-dihydro-thieno [2, 3-b] -benzo [e] thiepin-4-yliden) - piperidin-1-yl] -butyl }-3-pyridin-3-yl-acrylamide; N- [4- (4-diphenylphosphinoyloxypiperidin-l-yl) -butyl] -3- pyridin-3-yl-acrylamide as well as N- [4- (1, 4-dioxa-8-azaspiro [4.5] dec-8-yl) -butyl] -3-pyridin-3- yl-acrylamide; N- [4- (2, 5-dioxo-3, 4-diphenyl-2, 5-dihydropyrrol-l-yl) -butyl] - 3-pyridin-3-yl-acrylamide; N- [4- (2, 6-dioxo-4-phenylpiperidin-l-yl) -butyl] -3-pyridin-3- yl-acrylamide; N- [4- (1, 3-dioxo-4, 5, 6, 7-tetraphenyl-l, 3-dihydro-isoindol-2- yl ) -butyl ] -3-pyridin-3-yl-acrylamide ; N- [4- (3-benzyl-2, 4, 5-trioxo-imidazolidin-l-yl) -butyl] -3- pyridin-3-yl-acrylamide; N- [4- (1, 3, 10-trioxo-l, 4, 5, 6, 10, lOa-hexahydro-acenaphtho- [1, 8a-c]pyrrol-2-yl) -butyl] -3-pyridin-3-yl-acrylamide; N- [4- (2, 5-dioxo-4, 4-diphenylimidazolidin-l-yl) -butyl-3- pyridin-3-yl-acrylamide; N- [4- (2, 5-dioxo-3-phenyl-2, 5-dihydropyrrol-l-yl) -butyl] -3- pyridin-3-yl-acrylamide; 130 N- [ 3- ( 2 , 5-dioxo-3 , 4 -diphenyl-2 , 5-dihydro-pyrrol- l-yl ) - propyl] -3-pyridin-3-yl-acrylamide; N- [4- (3-pyridin-3-yl-acroylamino) -butyl] -2,3:5,6- dibenzobicyclo [2.2.2] octan-7, 8-dicarboximide; N- [4- (5-benzyliden-2, -dioxothiazolidin-3-yl) -butyl] -3- pyridin-3-yl-acrylamide; N- [4- (4-benzyl-2, 6-dioxopiperazin-l-yl) -butyl] -3-pyridin-3- yl-acrylamide; N- [6- (2, 5-dioxo-3, 4-diphenyl-2, 5-dihydropyrrol-l-yl) -hexyl] - 3-pyridin-3-yl-acrylamide; N- [4- (2, 5-dioxo-3, 4-diphenyl-2, 5-dihydropyrrol-l-yl) -butyl] - 3-pyridin-3-yl-propionamide; N- [4- (1, 3-dioxo-l, 3-dihydro-isoindol-2-yl) -butyl] -3-pyridin- 3-yl-acry1amide; N- [4- (1, 3-dioxo-lH, 3H-benzo [de] isoquinolin-2-yl) -butyl] -3- (1- oxidopyridin-3-yl) -acrylamide; N- [6- (1, 3-dioxo-lH, 3H-benzo [de] isoquinolin-2-yl) -hexyl] -3- pyridin-3-yl-acrylamide; N- [2- (1, 3-dioxo-lH, 3H-benzo [de] isoquinolin-2-yl) -ethyl] -3- pyridin-3-yl-acrylamide as well as N- [4- (1, 3-dioxo-lH, 3H-benzo [de] isoquinolin-2-yl) -butyl] -3- pyridin-3-yl-acrylamide; N- [8, 8-bis- (4-fluorophenyl) -octyl] -3-pyridin-3-yl- acrylamide»hydrochloride ; N- [6- (3, 3-diphenylureido) -hexyl] -3-pyridin-3-yl-acrylamide; N- [4- (1-phenyl-l, 2, 4, 5-tetrahydrobenzo [d] azepin-3-yl) -butyl] - 3-pyridin-3-yl-acrylamide; N- (8, 8-diphenyloctyl) -3-pyridin-3-yl-acrylamide; N- (8-hydroxy-8, 8-diphenyloctyl) -3-pyridin-3-yl-acrylamide; N- [4- (3, 3-diphenylureido) -butyl] -3-pyridin-3-yl-acrylamide; N- [4- (1H, 3H-benzo [de] isoquinolin-2-yl) -butyl] -3-pyridin- 3-yl-acrylamide; N- [6- (10, 11-dihydro-dibenzo [b, f] azepin-5-yl-carbonyl- amino) -hexyl] -3-pyridin-3-yl-acrylamide; 131 3-pyridin-3-yl-N- [ 6- ( tosylamino ) -hexyl ] -acrylamide ; N- [4- (1, l-dioxo-l-thia-2-aza-acenaphthylen-2-yl) -butyl] -3- pyridin-3-yl-acrylamide; N- ( 6-hydroxy-6, 6-diphenylhexyl) -3-pyridin-3-yl-acrylamide; N- ( 6, 6-diphenyl-hex-5-enyl) -3-pyridin-3-yl-acrylamide; N- [4- (4, 5-diphenylimidazol-l-yl) -butyl] -3-pyridin-3-yl- acrylamide; N- [4- (trans-2-Phenylcyclopropylcarbonylamino) -butyl] -3- pyridin-3-yl-acrylamide; N- (5-hydroxy-5, 5-diphenyl-pentyl) -3-pyridin-3-yl-acrylamide; N- (7-phenylheptyl) -3-pyridin-3-yl-acrylamide; N- (4-diphenylacetylamino-butyl) -3-pyridin-3-yl-acrylamide; N- [4- (benzhydrylamino) -butyl] -3-pyridin-3-yl-acrylamide as well as N- (4-{ [2- (benzhydrylmethylammo) -ethyl] -methylamino } -butyl) - 3-pyridin-3-yl-acrylamide . 4. Use according to one of claims 1 to 3, characterized in that compounds of the general formulas (II) to (lib) »23 R2 R2 OH OH R' > .^ :N ? 23 o R2< R 4 OH R2 <*> N (ii: Ilia) (lib) as well as compounds of formulas (III) to (IIIcl 132 ? 23 R23 ?22 OH R 22 OH " N ^ R 1 >21 N in ; : nia; R OH R 2 ? 21 N ? 21 N > R 24 >24 ( I Hb ) ; nic) wherein R 21 is selected from hydrogen, halogen, cyano, alkyl, especially C^-Cg-alkyl, trifluoromethyl, hydroxyalkyl, especially C -Cg- hydroxyalkyl, hydroxy, alkoxy, alkanoyloxy, alkylthio or aminoalkyl, especially C ] _-Cg-alkoxy, C]_-C7~alkanoyloxy, C^-Cg-alkylthio or C ] _-Cg-aminoalkyl, amino, alkylamino or dialkylamino, especially Ci-Cg-alkylamino or C2-C12- dialkylamino, formyl, alkoxycarbonyl, especially C2-C7- alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl, especially C2-C7- alkylaminocarbonyl or C3-Ci3-dialkylamino-carbonyl and carboxy; R22 is selected from 133 hydrogen, halogen, Alkyl, especially C ] _-Cg-alkyl, trifluoromethyl, hydroxyalkyl, especially C ] _-Cg- hydroxyalkyl, hydroxy, alkoxy, alkanoyloxy or aminoalkyl, especially Cχ-Cg-alkoxy, Cχ-C7~alkanoyloxy or Cχ-Cg-aminoalkyl, amino, alkoxycarbonyl, especially C2~C7-alkoxycarbonyl, aminocarbonyl and carboxy; R23 is selected from hydrogen, alkyl, especially C^-Cg-alkyl, and hydroxyalkyl, especially C_-Cg-hydroxyalkyl; R24 is selected from alkyl, alkenyl, hydroxyalkyl, alkoxyalkyl, especially C]_-Cg-alkyl, C3~Cg-alkenyl, C2~Cg-hydroxyalkyl or C2~C - alkoxyalkyl and aralkyl, especially benzyl; X- signifies a monovalent, non-basic anion selected from fluoride, chloride, bromide, iodide, hydrogen sulfate, methanesulfonate, trifluoromethanesulfonate, tosylate, tetrafluoroborate, dihydrogenphosphate and acetate, can be used as compounds with vitamin pp activity, whereby, optionally, ester compounds of formula (III) in form of the following general formulas (IV) to (IVb), their N-oxides (IVa), their analogous thioxo derivatives or quarternary salts (IVb) with mono- to hexavalent alcohols or amino alcohols, 134 R 23 R 23 " R 25 R" J 25 ^ ..^ R21 R21 ( IV) ( IVa ) >23 >22 R25 ^ R21 + N R24 ( IVb ) can also be used as compounds with vitamin pp activity, wherein R 21 to R 24 and X ~ have the above meanings, a can be the number 1 to 6, and the underlying alcohol R 25 (OH) a is selected from monovalent, straight-chained or branched, primary, secondary or tertiary Cι-C ] _o~alkanols or ω-dialkylamino alkanols or benzyl alcohol, divalent, straight-chained or branched C2-C_o-gly c °lene, 135 mono- or divalent C5-C7-cycloalkanols and/or-diolene, cycloalkylmethanols or saturated heterocyclomethanols such as tetrahydrofurylmethanol, tri-, tetra-, penta- or hexavalent, straight-chained or branched or cyclic alcohols with 3 to 10 carbon atoms such as glycerin, 2, 2-bis (hydroxymethyl) -octanol-1, erythritol, pentaerythritol, arabitol, xylitol, sorbitol, mannitol, isosorbitol, tetra (hydroxymethyl) cyclohexanol or inositol, whereby the amides of the following formulas to (V) to (Vb) , derived from the respective free acids of the above general formulas (III) to (IIIc), their N-oxides or quarternary salts with mono- or divalent amines or hydroxyalkylammes can also be optionally further used: R2 N ' !*> R 26 R21 (V) (Va) 136 R23 - R27 R22 N * R26 R21 " R24 (Vb ) wherein R 2 ^ to R 2 ^ and X ~ have the above meanings, b can represent the number 1 or 2 and, in the case that b = 1, the residues R 2 ^ and R 2 ^ are selected independently from each other from hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl or dialkylaminoalkyl, especially Cχ-Cg-alkyl, C]_-Cg- hydroxyalkyl, C3-Cg-alkoxyalkyl, C]_-Cg-aminoalkyl or C4-C12- dialkylaminoalkyl and carboxymethyl, and in the case that b = 2, the residue R 26 has the above meanings, the residue R 2" is selected from alkylene, especially C2-Cχo~ a lkylene or C5-C10- alkylene, wherein a methylene group is isosterically replaced by 0, NH or N-alkyl; and/or, depending on the molecular binding properties of the compounds according to the above formulas (II) to (Vb) , their 137 acid addition salts, anionic salts, their N-oxides, especially according to the formulas (Ila) and (Ilia), and quarternary pyridinium salts, especially according to the formulas (lib), (Illb) and (IIIc), optionally their respective analogous thioxo derivatives as well or a precursor compound (prodrug) are used which can be metabolized in vivo to a compound with vitamin PP - activity as well as other pharmacologically acceptable esters or other derivatives with pharmacokinetically useful vitamin PP- activity not defined by the above substitutents . 5. Use according to one of claims 1 to 4, characterized in that nicotinic acid and/or nicotinamide are used as a vitamin PP active compounds . 6. Use according to one of claims 1 to 4, characterized in that tryptophan is used as a precursor compound (prodrug) which is metabloized in vivo to a compound with vitamin PP activity. 7. Use according to one of claims 1 to 7, characterized in that in addition to the cancerostatic agent, especially a compound characterized in claim 2 or 3, a further cancerostatic or immunosuppressive compound different from the tumor inhibitor according to the general formula (I) is used. 8. Use according to one of claims 1 to 7, characterized in that, the respective dosage units of compounds of the general formula (I) are in the range of 5, 10, 20, 25, 30, 50, 75, 100, 200, 250, 300, 400, 500, 750 mg to 1000 mg for reduction, elimination or prevention of less severe side- effects, and 100, 250, 300, 500, 750 or 1000 to 10,000 mg for 138 elimination of acute side-effects and/or for neutralization of the cancerostatic effect. 9. Pharmaceutical composition, characterized in that it contains one or more compounds of the general formula (I) according to claim 2 and one or more compounds of the general formulas (II) to (Vb) according to claim 4 aside from physiologically acceptable carriers and toxicologically safe adjuvants . 10. Pharmaceutical composition according to claim 9, characterized in that in addition to the cancerostatic agent, especially a compound characterized in claim 2 or 3, it further contains a cancerostatic or immunosuppressive compound different from the tumor inhibitor according to the general formula (I) . 11. Pharmaceutical composition according to claims 9 or 10, characterized in that it contains the respective dosage units of the compounds of the general formula (I) in the range of 5, 10, 20, 25, 30, 50, 100, 200, 250, 300, 500, 750, 1000 mg to 1000 mg in cancerostatic chemotherapy for reduction, elimination or prevention of less severe side-effects and respectively contains 100, 200, 250, 300, 500, 750 or 1000 to 10 000 mg for elimination of acute side-effects and/or neutralization of cancerostatic effect. 12. Pharmaceutical composition according to one of claims 9 to 11, characterized in that in addition to the cancerostatic agent it further contains one or more active ingredients customary for the indications given in the preceding claims in combination with one or more of the compounds of the general formulas (II) to (Vb) . 139 13. Pharmaceutical composition according to one of the claims 9 to 12, characterized in that it is present in a solid, peroral administrable form as a tablet, capsule, coated tablet, optionally as sustained action and/or gastric fluid-resistant preparation or as a liquid medicinal form, for example, as a respective peroral administrable solution, suspension, effervescent tablet, in the form of tabs or sachets, optionally in sustained action form and/or with delayed and/or accelerated or controlled release of the active ingredient . 14. Pharmaceutical composition according to one of the claims 9 to 12, characterized in that the active ingredients combined with each other are contained separate from each other and/or in separate dosage units in the pharmaceutical package (kit-of-parts) . 15. Pharmaceutical composition according to one of the claims 9 to 12 or 14, characterized in that it is present in the form of a suitable injection or infusion preparation together with suitable pharmaceutically acceptable carriers and adjuvants, optionally in sustained action form and/or as a parenteral depot medicinal form or implant or is used in the form of a concentrate, powder or lyophilisate and the parenteral dilution agent is optionally manufactured in the packaging separately therefrom, such that the mixing of the components contained therein with a common parenterally applicable dilution agent is possible immediately before use. 16. Pharmaceutical composition according to one of the claims 9 to 12, characterized in that it is present in the form of an inhalation therapeutic agent, for example, in the form of a spray together with suitable pharmaceutically acceptable propellants, carriers and adjuvants. 140 17. Pharmaceutical composition according to one of the claims 9 to 12, characterized in that it is present in the form of a transdermal therapeutic system for systemic treatment . 18. Pharmaceutical composition according to one of the claims 9 to 12, characterized in that it is present in the form of a gastrointestinal therapeutic system (GITS) for systemic treatment . 19. Pharmaceutical composition according to one of the claims 9 to 12, characterized in that it is present in the form of a salve, suspension, emulsion, a balm or plaster or in the form of an externally applicable solution. 20. Pharmaceutical composition according to claim 16 for administration by means of a controlled dosage aerosol or in the form of a dry powder dosage formulation. 21. Pharmaceutical composition according to one of the claims 9 to 12, characterized in that it is present in the form of a rectal, genital, or transurethral administrable emulsions, a solution, a liposomal solution, an implant, suppository or a capsule. 22. Pharmaceutical composition according to one of the claims 9 to 12, characterized in that it is present in the form of a composition capable of being applied nasally, otologically or ophthalmologically . 23. Pharmaceutical composition according to one of the claims 9 to 12, characterized in that it is present in the form of a buccally applicable form. 24. Pharmaceutical composition according to one of the claims 9 to 23, characterized in that a dosage unit for 141 individual administration contains 0.001 to 1000, 2000, 3000, 4000 or 5000 mg, preferably 0.01 - 100 mg, in a preferred manner 1 - 10 mg, especially 1, 2, 5, 10, 20, 25, 30, 50, 75, 100, 200, 300, 400, 500, 600, or 800 mg cancerostatic agent, especially a tumor inhibitor of the general formula (I) . 25. Pharmaceutical composition according to claim 16, characterized in that the pharmaceutically acceptable carrier and/or diluent is a propellant aerosol. 26. Pharmaceutical composition according to claim 16, 20 or 25, characterized in that the propellant aerosol is tetrafluoroethane and/or heptafluoropropane and/or propane, butane, or dimethyl ether or mixtures thereof. 27. Pharmaceutical composition according to one of the claims 16, 20, 25 or 26, characterized in that the propellant aerosol contains surface active adjuvants. 28. Pharmaceutical composition according to one of the claims 16 or 20, characterized in that it contains glucose and/or lactose as a dry powder dosage formulation. 29. Pharmaceutical composition according to one of the claims 9 to 28, characterized in that it has an amount of tryptophan as a prodrug. 30. Pharmaceutical composition according to claim 29, characterized in that it contains the 30-, 40-, 50-, or 60- fold amount of the amount given in claim 11 of compound with vitamin PP activity. 31. Pharmaceutical composition according to claim 30, characterized in that it contains dosage units of 500, 1000, 2000, 3000, 5000, 10,000 or 50,000 mg tryptophan.

Inventors: BIEDERMANN ELFI, HASMANN MAX, LOESER ROLAND, RATTEL BENNO, REITER FRIEDEMANN, SCHEIN BARBARA, SCHEMAINDA ISABEL, SEIBEL KLAUS, VOGT KLAUS, WOSIKOWSKI KATJA, BIEDERMANN, ELFI, HASMANN, MAX, LOESER, ROLAND, RATTEL, BENNO, REITER, FRIEDEMANN, SCHEIN, BARBARA, SCHEMAINDA, ISABEL, SEIBEL, KLAUS, VOGT, KLAUS, WOSIKOWSKI, KATJA
Applicants: BIEDERMANN ELFI, HASMANN MAX, KLINGE CO CHEM PHARM FAB, LOESER ROLAND, RATTEL BENNO, REITER FRIEDEMANN, SCHEIN BARBARA, SCHEMAINDA ISABEL, SEIBEL KLAUS, VOGT KLAUS, WOSIKOWSKI KATJA, BIEDERMANN, ELFI, HASMANN, MAX, KLINGE PHARMA GMBH, LOESER, ROLAND, RATTEL, BENNO, REITER, FRIEDEMANN, SCHEIN, BARBARA, SCHEMAINDA, ISABEL, SEIBEL, KLAUS, VOGT, KLAUS, WOSIKOWSKI, KATJA
Application year: 1999
Main classification: A61K31
IPC codes: A61K9, A61K31, A61K45, A61K47, A61P35, A61P37, A61P39, A61P43