AZACYCLOOCTANE AND HEPTANE DERIVATIVES, THEIR PREPARATION AND USEIN THERAPY

Abstract: The present invention discloses compounds of formula (1) or (2), any of its enantiomers or any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein n is 0, or 1; R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl; and R<1> is aryl which may be substituted one or more times with substituents selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl alkenyl, alkynyl, alkoxy, cycloalkoxy, thioalkoxy, thiocycloalkoxy, methylenedioxy, aryloxy, halogen, CF3, OCF3, CN, amino, nitro, aryl and a monocyclic 5 to 6-membered heteroaryl group a monocyclic 5 to 6- membered heteroaryl group which may be substituted one or more times with substituents selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl alkenyl, alkynyl, alkoxy, cycloalkoxy, thioalkoxy, thiocycloalkoxy, methylenedioxy, aryloxy, halogen, CF3, OCF3, CN, amino, nitro, aryl and a monocyclic 5 to 6-membered heteroaryl group, or a bicyclic heteroaryl group composed of a monocyclic 5 to 6-membered heteroaryl group fused to a benzene ring and which may be substituted one or more times with substituents selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl alkenyl, alkynyl, alkoxy, cycloalkoxy, thioalkoxy, thiocycloalkoxy, methylenedioxy, aryloxy, halogen, CF3, OCF3, CN, amino, nitro, aryl and a monocyclic 5 to 6-membered heteroaryl group. The compounds of the invention are useful as nicotinic ACh receptor ligands.

Description: AZACYCLOOCTANE AND HEPTANE DERIVATIVES , THEIR PREPARATION AND USE IN THERAPY The present invention relates to novel Azabicyclooctane and heptane derivatives which are cholinergic ligands at nicotinic ACh receptors. The compounds of the invention are useful for the treatment of condition or disorders or diseases involving the cholinergic system of the central nervous system, pain, inflammatory diseases, diseases caused by smooth muscle contractions and as assistance in the cessation of chemical substance abuse. Background The endogenous cholinergic neurotransmitter, acetylcholine, exert its biological effect via two types of cholinergic receptors; the muscarinic ACh receptors and the nicotinic ACh receptors. As it is well established that muscarinic ACh receptors dominate quantitatively over nicotinic ACh receptors in the brain area important to memory and cognition, much research aimed at the development of agents for the treatment of memory related disorders have focused on the synthesis of muscarinic ACh receptor modulators. Recently, however, an interest in the development of nicotinic ACh receptor modulators has emerged. Several diseases are associated with degeneration of the cholinergic system i.e. senile dementia of the Alzheimer type, vascular dementia and cognitive impairment due to the organic brain damage disease related directly to alcoholism. Indeed several CNS disorders can be attributed to a cholinergic deficiency, a dopaminergic deficiency, an adrenergic deficiency or a serotonergic deficiency. Alzheimer's disease is characterised by a profound loss of memory and cognitive functions caused by a severe depletion of cholinergic neurons, i.e. neurons that release acetylcholine. A reduction in the number of nicotinic ACh receptors are also observed with the progression of Alzheimer's disease. It is believed that the neurons in the cortex that die with the progression of Alzheimer's disease do so because of lack of stimulation of the nicotinic ACh receptors. It is predicted that treatment of Alzheimer's patients with nicotinic ACh receptor modulators will not only improve the memory of patients but in addition act to keep these neurons alive. Smoking actually seems to protect individuals against neurodegeneration and compounds behaving on these receptor may very likely have a generally neuroprotective effect. However degeneration of the cholinergic system is not limited to individuals suffering from i.e. Alzheimers disease but is also seen in healthy aged adults and rats. Therefore it is suggested that the cholinergic system is involved and partly responsible for the memory disturbances seen in aged animals and humans. Nicotine receptor modulator may therefore be useful in the treatment of Alzheimer's disease, memory loss, memory dysfunction, AIDS-dementia, senile dementia or neurodegenerative disorders. Parkinsons disease appears to involve degeneration of dopaminergic neurons. One symptom of the disease has been observed to be loss of nicotinic receptors associated with the dopaminergic neurons and possibly interfering with the process of release of dopamine. As sustained nicotine administration increases the number of receptors present, administration of nicotine receptor modulators may ameliorate the symptoms of Parkinson's disease. Other condition or disorders or disease ascribed to deficiencies in the dopaminergic system is: drug addiction, depression, obesity and narcolepsy. Tourette's syndrome is a neuropsychiatric disorder involving a range of neurological and behavioral symptoms. It is believed that neurotransmitter dysfunction is involved though the pathophysiology is still unknown and that nicotine will be beneficial in the treatment of the disease (Devor et. al. The Lancet, vol. 8670 p. 1046, 1989) Schizophrenia is a severe psychiatric illness. Neuroleptic compounds has been used in the treatment of the disease, the effect of the compounds is believed to be interaction in the dopaminergic system. Nicotine is proposed to be effective in the treatment of schizophrenia (Merriam et. al. Psychiatr. annals, Vol. 23, p. 171 -178, 1993 and Adier et. al. Biol. Psychiatry, Vol. 32, p. 607-616, 1992.) Nicotine has been reported to have en effect on neurotransmitter release in several systems. Release of acetylcholine and dopamine by neurons upon administration of nicotine has been reported (J. Neurochem. vol. 43, 1593-1598, 1984) and release of norepinephrine by Hall et. al. (Biochem. Pharmacol, vol. 21 , 1829-1838, 1972) Release of serotonin by Hery et. al. (Arch. Int. Pharmacodyn. Ther. vol. 296. p. 91-97, 1977). Release of glutamate by Toth et. al (Neurochem. Res. vol. 17, p. 265-271 , 1992) The serotonin system and dysfunction's of the serotonergic system is believed to be involved in diseases or conditions or disorders like: anxiety, depression, eating disorders, obsessive compulsive disorder, panic disorders, chemical substance abuse, alcoholism, pain, memory deficits and anxiety, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, pre-menstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism or trichotillomania. Nicotine improves concentration and task performance . Therefore compounds exhibiting nicotine receptor modulating properties will be likely to be useful compounds in the treatment of learning deficit, cognition deficit, attention deficit, attention deficit hyperactivity disorder and dyslexia. Tobacco use and especially cigarette smoking is recognised as a serious health problem. However nicotine withdrawal symptoms associated with smoking cessation makes it difficult to break this habit. Withdrawal symptoms include anger, anxiety, difficulties in concentrating, restlessness, decreased heart rate and increased appetite and weight gain. Nicotine itself has shown to ease the withdrawal symptoms. Withdrawal from addictive substances, i.e. opiates, benzodiazepines, ethanol, tobacco or nicotine, is in general a traumatic experience characterised by anxiety and frustration. Nicotine has been found to be effective in reducing anger, irritability, frustration and feelings of tension without causing general response depression, drowsiness or sedation and compounds having same characteristics as nicotine is likely to have same effects. Mild to moderate pain is normally treatable with NSAID's (non-steroidal anti-inflammatory drugs) while opiates are used preferentially for moderate to severe pain. The opiates have some well-known side-effects, including chemical dependence and abuse potential as well as a depressive effect on the respiratory and gastrointestinal system. There exists therefore a strong need for analgesic compounds that do not exhibit these side effects and which can relieve mild, moderate and severe pain of acute, chronic or recurrent character as well as migraine pain and postoperative pain, phantom limb pain. Epibatidine, a compound isolated from the skin of a poison frog, is a very potent analgesic with an approximate potency of 500 times that of morphine. The analgesic effect is not affected by naloxone, which is an indication of a negligible affinity for the opiate receptors. Epibatidine is an nicotinic cholinergic receptor agonist and it is therefore very likely, that compounds possessing this receptor modulating character will also show a strong analgesic response. The compounds of the present invention has proven useful for modulation of smooth muscle contractions and may therefore be used in the treatment or prevention of condition or disorders or diseases inherent from smooth muscle contractions like i.e. convulsive disorders, angina pectoris, premature labor, convulsions, diarrhoea, asthma, epilepsy, tardive dyskinesia, hyperkinesia. Further, it is well known that nicotine has an effect on appetite and it is predicted that modulators at the nicotine ACh receptor may be useful as appetite suppressants in the treatment of obesity and eating disorders. The cholinergic receptors play an important role in the functioning of muscles, organs and generally in the central nervous system. There are also complex interactions between cholinergic receptors and the function of receptors of other neurotransmitters such as dopamine, serotonin and noradrenaline. It is likely that nicotine receptor modulator compounds can be effective in preventing or treating conditions or disorders or diseases like: inflammation, inflammatory skin conditions, Chron's disease, inflammatory bowel disease, ulcerative collitis, diarrhoea, neurodegeneration, perpherical neuropathy, amyotrophic lateral sclerosis, nociception, endocrine disorders, thyrotoxicosis, pheochromocytoma, hypertension, arrhytmias, mania, manic depression, Huntington's disease, jetlag. The compounds of the present invention are nicotine receptor modulators and has the potential to exhibit nicotinic pharmacology, preferentially without the side effects associated with nicotine itself. Additionally, the compounds are expected to have the potential as enhancers of neurotransmitter secretion and suppress symptoms associated with a low activity of neurotransmitters. Close structural analogues to the compounds of the present invention has been described in prior art: J. Org. Chem. (1995), 60(16), 4969-4961 describes a synthesis of amines by Schmidt reaction of aliphatic azides whereby 1-butylhexahydro-2-phenyl-1 H-azepine is produced. Monatsh. Chem. (1971 ), 102(2), 513-516 describes synthetic methods for achieving 3,4,5,6- tetrahydro-7-phenyl-2H-azepine, 7-(3,4-dimethoxyphenyl)-3,4,5,6-tetrahydro-2H-Azepine, hexahydro-2-phenyl-1 H-azepine, and 2-(3,4-dimethoxyphenyl)hexahydro-1 H-azepine; Tetrahedron Lett. (1978). (22),1901 -1904 describes the iodomethylation and stereoselectivity of nicotine and related compounds such as hexahydro-1 -methyl-2-(S)(3-pyridinyl)-1 H-azepine. J. Am. Chem. Soc. (1989), 1 1 1 (16), 6465-6 products formed by a photochemical reaction, such product being for example: hexahydro-1-methyl-2-phenyl-1 H-azepine and octahydro-1 - methyl-2-phenyl-azocine; J. Chromotogr., Biomed. Appl. (1993), 619(1 ), 49-61 describes a chromatographic-mass spectrometric method for determination of anabasine and other tobacco alkaloids such as: hexahydro-2-(3-pyridinyl)-1 H-azepine and 3,4,5,6-tetrahydro-7-(3-pyridinyl)-2H-azepine; The compound 1 -H-2-(3-pyridyl)azacycloheptane was previously described in Tetrahedron Letters (1978), 22, 1909-1904; Objects of the invention It is an object of the present invention to provide novel Azabicyclooctane and heptane derivatives which are useful for the treatment of a range of diseases and disorders characterised by decreased cholinergic function or responsive to the activity of nicotinic ACh receptor modulators. Another object of the present invention is to provide novel pharmaceutical compositions containing these compounds, as well as methods for the preparation thereof and methods for the treatment therewith. Other objects will become apparent hereinafter to one skilled in the art. The present invention In the context of this invention "treating" covers treatment, prevention, profylaxis or alleviation and "disease" covers a disease or a disorder or a condition. In In the context of this invention "modulator" covers agonists, partial agonists, antagonists and allosterical modulators. the context of this invention disorders in the central nervous system covers for example: neurodegenerative disorders, cognitive or memory dysfunction, Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic Lateral Sclerosis, Gilles de la Tourettes syndrome, attention deficit hyperactivity disorder, anxiety, depression, mania, manic depression, schizophrenia, obsessive compulsive disorders, eating disorders like anorexia nervosa, bulimia and obesity, narcolepsy, nociception, memory loss, memory dysfunction, AIDS-dementia, senile dementia , peripherial neuropathy, learning deficit, cognition deficit, attention deficit, autism, dyslexia, tardive dyskinesia, hyperkinesia, epilepsy, bulimia, post- traumatic syndrome, social phobia, chronic fatigue syndrome, disorders of sleep, pseudodementia, Ganser's syndrome, prementraul syndrome, late luteal phase syndrome, chronic fatigue syndrome, premature ejaculation, erectile difficulty, mutism and trichotillomania. In the context of this invention inflammatory conditions covers for example: inflammatory skin conditions like acne and rosacea, Chron's disease, inflammatory bowel disease, ulcerative collitis, diarrhoea. Diseases associated with smooth muscle contractions covers for example: convulsive disorders, angina pectoris, premature labor, convulsions, diarrhoea, asthma, epilepsy, tardive dyskinesia, hyperkinesia. In the context of this invention pain covers for example chronic, acute and recurrent pain, postoperative pain, migraine pain or phantom limb pain; Abuse of chemical substances covers smoking as well as use of other nicotine containing products, use of opiods like heroin, cocaine and morphine, use of benzodiazepines or alcohol. In this context "treatmenf covers treatment, prevention, profylaxis and alleviation of withdrawal symptoms and abstinence as well as treatment resulting in a voluntary diminished intake of the addictive substance. The invention then, inter alia, comprises the following, alone or in combination: A compound having the formula, 1 2 any of its enantiomers or any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein n is 0, or 1 ; R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl; and R 1 is aryl which may be substituted one or more times with substituents selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl alkenyl, alkynyl, alkoxy, cycloalkoxy, thioalkoxy, thiocycloalkoxy, methylenedioxy, aryloxy, halogen, CF 3 , OCF 3 , CN, amino, nitro, aryl and a monocyclic 5 to 6-membered heteroaryl group; or a monocyclic 5 to 6-membered heteroaryl group which may be substituted one or more times with substituents selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl alkenyl, alkynyl, alkoxy, cycloalkoxy, thioalkoxy, thiocycloalkoxy, methylenedioxy, aryloxy, halogen, CF 3 , OCF 3 , CN, amino, nitro, aryl and a monocyclic 5 to 6- membered heteroaryl group; or a bicyclic heteroaryl group composed of a monocyclic 5 to 6 membered heteroaryl group fused to a benzene ring and which may be substituted one or more times with substituents selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, thioalkoxy, thiocycloalkoxy, methylenedioxy, aryloxy, halogen, CF 3 , OCF 3 , CN, amino, nitro, aryl and a monocyclic 5 to 6 membered heteroaryl group; A preferred embodiment of the invention is a compound of formulas 1 and 2 wherein n is O, or 1 ; R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl; and R 1 is aryl which is substituted one or more times with substituents selected from the group consisting of cycloalkyl, cycloalkylalkyl alkenyl, alkynyl, thioalkoxy, cycloalkoxy, thiocycloalkoxy, methylenedioxy, aryloxy, halogen, CF 3 , OCF 3 , CN, amino, nitro, aryl and a monocyclic 5 to 6-membered heteroaryl group; or a monocyclic 5 to 6-membered heteroaryl group which may be substituted one or more times with substituents selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl alkenyl, alkynyl, alkoxy, thioalkoxy, thiocycloalkoxy, methylenedioxy, aryloxy cycloalkoxy, halogen, CF 3 , OCF 3 , CN, amino, nitro, aryl and a monocyclic 5 to 6-membered heteroaryl group; or a bicyclic heteroaryl group composed of a monocyclic 5 to 6 membered heteroaryl group fused to a benzene ring and which may be substituted one or more times with substituents selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl alkenyl, alkynyl, alkoxy, thioalkoxy, thiocycloalkoxy cycloalkoxy, methylenedioxy, aryloxy, halogen, CF 3 , OCF 3 , CN, amino, nitro, aryl and a monocyclic 5 to 6 membered heteroaryl group; provided that the compound is not: hexahydro-2-(3-pyridinyl)-1 H-azepine or hexahydro-1 -methyl-2-(S)-(3-pyridinyl)-1 H-azepine; Another preferred embodiment of the invention is compound formula 1 or 2, wherein n is 0, or 1 ; R is hydrogen or methyl and R 1 is 3-pyridyl, 3-quinolinyl, 6-thioethy l-3-py ri dy I or 5-thioethyl-3-pyridyl; Another preferred embodiment of the invention is a compound as above which is (R,S)-1 -H-2-(3-pyridyl)azacyclooctane; (R,S)-1-H-2-(3-pyridyl)azacycloheptane; (R,S)-1-H-2-(3-quinolinyl)azacyclooctane; (R,S)-1-H-2-(6-thioethyl-3-pyridyl)azacycloheptane; (R,S)-1-H-2-[5-thioethyl-3-pyridyl)azacycloheptane; (R,S)-1-H-2-(5-thioethyl-3-pyridyl)azacyclooctane; (R,S)-1-Methyl-2-(3-pyridyl)azacyciooctane; (R,S)-1-Methyl-2-(3-quinolinyl)azacyclooctane; (R,S)-1-Methyl-2-(6-thioethyl-3-pyridyl)azacycloheptane; (R,S)-1-Methyl-2-(5-thioethyl-3-pyridyl)azacycloheptane; (R,S)-1 -Methyl-2-(5-thioethyl-3-pyridyl)azacyclooctane; 1 c:2-(3-Pyridyl)azacyclooct-1 -ene; 2-(3-Quinolinyl)azacyclooct-1 -ene or 2-(5-thioethyl-3-pyridyl)azacyclooct-1-ene; or a pharmaceutically acceptable addition salt thereof. a pharmaceutical composition, comprising a therapeutically effective amount of a compound as above, or a pharmaceutically acceptable addition salt thereof, together with at least one pharmaceutically acceptable carrier or diluent; the use of a compound as above for the manufacture of a medicament for the treatment or prevention of a condition or disorder or disease of a living animal body, including a human, which condition or disorder or disease is responsive to the activity of nicotinic ACh receptor modulators; the use of a compound as above wherein the disease to be treated is pain, a disease in the central nervous system, a disease caused by smooth muscle contraction, neurodegeneration, inflammation, chemical substance abuse or withdrawal symptoms caused by the cessation of intake of the chemical substance. The use as above wherein the disease is a disease in the central nervous system said disease being Alzheimer's disease, Parkinson's disease, memory dysfunction or attention deficit hyperactivity disorder. The use as above wherein the disease to be treated is chemical substance abuse or withdrawal symptoms caused by the cessation of intake of the chemical substance, said chemical substance abuse being smoking or use of other nicotine containing products and withdrawal symptoms caused by cessation of use of nicotine containing products; a method for the preparation of the compounds as above comprising the step of a) reacting a compound having the formula wherein n is as defined above, with a compound of the formula R 1 -Li, wherein R 1 is as defined above; to form a compound of formula wherein n and R 1 is as defined above, or b) oxidising a compound having the formula wherein R 1 and n is as defined above, to form a compound having the formula wherein R 1 and n is as defined above; a method of treating a disease of a living animal body, including a human, which disease is responsive to the activity of nicotinic ACh receptor modulators, comprising the step of administering to such a living animal body, including a human, in need thereof a therapeutically effective amount of a compound as above; the method as above wherein pain, a disease of the central nervous system, neurodegeneration, inflammation, chemical substance abuse, withdrawal symptoms from cessation of use of addictive substances, or a disease caused by smooth muscle contractions is treated; The method as above wherein chemical substance abuse or withdrawal symptoms caused by the cessation of intake of the chemical substance, said chemical substance abuse being smoking or use of other nicotine containing products and withdrawal symptoms caused by cessation of use of nicotine containing products, is treated; The method as above wherein a disease in the central nervous system, said disease being Alzheimer's disease, Parkinson's disease, memory dysfunction or attention deficit hyperactivity disorder, is treated; Examples of pharmaceutically acceptable addition salts include inorganic and organic acid addition salts such as the hydrochloride, hydrobromide, phosphate, nitrate, perchlorate, sulphate, citrate, lactate, tartrate, maleate, fumarate, mandelate, benzoate, ascorbate, cinnamate, benzenesulfonate, methanesulfonate, stearate, succinate, glutamate, glycollate, toluene-p-sulphonate, formate, malonate, naphthalene-2-sulphonate, salicylate and the acetate. Such salts are formed by procedures well known in the art. Other acids such as oxalic acid, while not in themselves pharmaceutically acceptable, may be useful in the preparation of salts useful as intermediates in obtaining compounds of the invention and their pharmaceutically acceptable acid addition salts. Halogen is fluorine, chlorine, bromine or iodine. Alkyl means a straight chain or branched chain of one to six carbon atoms, including but not limited to, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, pentyl, and hexyl; methyl, ethyl, propyl and isopropyl are preferred groups. Cycloalkyl means cyclic alkyl of three to seven carbon atoms, including but not limited to cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl; Alkenyl means a group of from two to six carbon atoms, including at least one double bond, for example, but not limited to ethenyl, 1 ,2- or 2,3-propenyI, 1 ,2-, 2,3-, or 3,4-butenyl. Alkynyl means a group of from two to six carbon atoms, including at least one triple bond, for example, but not limited to ethynyl, 1 ,2- or 2,3-propynyl, 1 ,2- or 2,3- or 3,4-butynyl. Cycloalkylalkyl means cycloalkyl as above and alkyl as above, meaning for example, cyclopropylmethyl. Alkoxy is O-alkyl, wherein alkyl is as defined above. Cycloalkoxy is O-cycloalkyl, wherein cycloalkyl is as defined above. Thioalkoxy is S-alkyl, wherein alkyl is as defined above. Thiocycloalkoxy is S-cycloalkyl wherein cycloalkyl is as defined above. Amino is NH 2 or NH-alkyl or N-(alkyl) 2 , wherein alkyl is as defined above. A monocyclic 5- to 6-membered heteroaryl group contain one, two three or four heteroatoms and includes, for example, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, 1 ,2,4-oxadiazol-3-yl, 1 ,2,4-oxadiazol-5-yl, 1 ,2,4-thiadiazol-3-yl, 1 ,2,4-thiadiazol-5-yl, 1 ,2,5- oxadiazol-3-yl, 1 ,2,5-oxadiazol-4-yl, 1 ,2,5-thiadiazol-3-yl, 1 ,2,5-thiadiazol-4-yl, 1 -imidazoiyl, 2- imidazolyl, 4-imidazolyl, 1-pyrrolyl, 2-pyrrolyl, 3-pyrrolyl, 2-furanyl, 3-furanyI, 2-thienyl, 3- thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4- pyridazinyl, 2-pyrazinyl and 3-pyrazinyl and 1 -pyrazolyl, 3-pyrazolyl, and 4-pyrazolyl. A bicyclic heteroaryl group composed of a 5 to 6 membered monocyclic heteroaryl group and a fused benzene ring means a monocyclic 5 to 6 membered heteroaryl group as above which is fused to a benzene ring including, for example, 2-, 3-, 4-, 5-, 6-, 7-benzofuranyl, 1 -, 2-, 4-, 5- benzimidazolyl, 2-, 3-, 4-, 5-, 6-, 7-indolyl, 2-,3-,4- ,5-,6-,7-,8-quinolinyl and 1-,3-,4-,5-,6-,7-,8-isoquinolinyl. Aryl is an aromatic hydrocarbon, such as phenyl and naphthyl. Aryloxy is O-aryl, wherein aryl is as defined above. Further, the compounds of this invention may exist in unsolvated as well as in solvated forms with pharmaceutically acceptable solvents such as water, ethanol and the like. In general, the solvated forms are considered equivalent to the unsolvated forms for the purposes of this invention. It will be appreciated by those skilled in the art that the compounds of the present invention contain several chiral centres and that such compounds exist in the form of isomers (i.e. enantiomers). The invention includes all such isomers and any mixtures thereof including racemic mixtures. Racemic forms can be resolved into the optical antipodes by known methods, for example, by separation of diastereomeric salts thereof with an optically active acid, and liberating the optically active amine compound by treatment with a base. Another method for resolving racemates into the optical antipodes is based upon chromatography on an optically active matrix. Racemic compounds of the present invention can thus be resolved into their optical antipodes, e.g., by fractional crystallization of d- or I- (tartrates, mandelates, or camphorsulphonate) salts for example. The compounds of the present invention may also be resolved by the formation of diastereomeric amides by reaction of the compounds of the present invention with an optically active activated carboxylic acid such as that derived from (+) or (-) phenylalanine, (+) or (-) phenylglycine, (+) or (-) camphanic acid or by the formation of diastereomeric carbamates by reaction of the compounds of the present invention with an optically active chloroformate or the like. Additional methods for the resolvation of optical isomers, known to those skilled in the art may be used, and will be apparent to the average worker skilled in the art. Such methods include those discussed by J. Jaques, A. Collet, and S. Wilen in "Enantiomers, Racemates, and Resolutions", John Wiley and Sons, New York (1981). Optical active compounds can also be prepared from optical active starting materials. The compounds of the invention may be prepared by any conventional method useful for the preparation of analogous compounds and as described in the examples below. Starting materials for the processes described in the present patent application are known or can be prepared by known processes from commercially available materials A compound of the invention can be converted to another compound of the invention using conventional methods. The products of the reactions described herein are isolated by conventional means such as extraction, crystallisation, distillation, chromatography, and the like. Biology Nicotinic ACh receptors in the brain are pentameric structures composed of subunits distinct from those found in skeletal muscles. The existence of eight α-subunits (α2-α9) and three β- subunits (β2 -β4) in the mammalian brain has been described. The predominant subtype with high affinity for nicotine is comprised of three and two β 2 subunits. The affinity of compounds of the invention for nicotinic ACh receptors have been investigated in three test for in vitro inhibition of 3 H-epibatidin binding, 3 H-α-bunga- rotoxin binding and 3 H-cytisine binding as described below: In vitro inhibition of 3 H-cytisine binding The predominant subtype with high affinity for nicotine is comprised of c and β 2 subunits. nAChRs of the latter type can selectively be labelled by the nicotine agonist 3 H-cytisine. Tissue Preparation: Preparations are performed at 0-4°C unless otherwise indicated. Cerebral corticies from male Wistar rats (150-250 g) are homogenized for 20 sec in 15 ml Tris, HCI (50 mM, pH 7.4) containing 120 mM NaCI, 5 mM KCI, 1 mM MgCI 2 and 2.5 mM CaCI 2 using an Ultra-Turrax homogenizer. The homogenate is centrifuged at 27,000 x g for 10 min. The supernatant is discarded and the pellet is resuspended in fresh buffer and centrifuged a second time. The final pellet is resuspended in fresh buffer (35 ml per g of original tissue) and used for binding assays. Assay: Aliquots of 500 μl homogenate are added to 25 μl of test solution and 25 μl of 3 H- cytisine (1 nM, final concentration), mixed and incubated for 90 min at 2°C. Non-specific binding is determined using (-)-nicotine (100 μM, final concentration). After incubation the samples are added 5 ml of ice-cold buffer and poured directly onto Whatman GF/C glass fibre filters under suction and immediately washed with 2 x 5 ml ice-cold buffer. The amount of radioactivity on the filters is determined by conventional liquid scintillation counting. Specific binding is total binding minus non-specific binding. In vitro inhibition of 3 H-α-bungarotoxin binding Rat brain α-Bungarotoxin is a peptide isolated from the venom of the Elapidae snake Bungarus multicinctus (Mebs et al., Biochem. Biophys. Res. Commun., 44(3), 711 (1971)) and has high affinity for neuronal and neuromuscular nicotinic receptors, where it acts as a potent antagonist. 3 H-α-Bungarotoxin binds to a single site in rat brain with an unique distribution pattern in rat brain (Clarke et al., J. Neurosci. 5, 1307-1315 (1985)). 3 H-α-Bungarotoxin labels nAChR formed by the α 7 subunit isoform found in brain and the <xι isoform in the neuromuscular junction (Changeaux, Fidia Res. Found. Neurosci. Found. Lect. 4, 21-168 (1990). Functionally, the α homo-oligomer expressed in oocytes has a calcium permeability greater than neuromuscular receptors and, in some instances greater than NMDA channels (Seguela et al., J. Neurosci. 1J3, 596-604 (1993). Tissue preparation: Preparations are performed at 0-4°C unless otherwise indicated. Cerebral cortices from male Wistar rats (150-250 g) are homogenized for 10 sec in 15 ml 20 mM Hepes buffer containing 118 mM NaCI, 4.8 mM KCI, 1.2 mM MgSO 4 and 2.5 mM CaCI 2 (pH 7.5) using an Ultra-Turrax homogenizer. The tissue suspension is centrifuged at 27,000 x g for 10 min. The supernatant is discarded and the pellet is washed twice by centrifugation at 27,000 x g for 10 min in 20 ml fresh buffer, and the final pellet is resuspended in fresh buffer containing 0.01 % BSA (35 ml per g of original tissue) and used for binding assays. Assay: Aliquots of 500 μl homogenate are added to 25 μl of test solution and 25 μl of 3 H-α- bungarotoxin (2 nM, final concentration), mixed and incubated for 2 h at 37°C. Non-specific binding is determined using (-)-nicotine (1 mM, final concentration). After incubation the samples are added 5 ml of ice-cold Hepes buffer containing 0.05% PEI and poured directly onto Whatman GF/C glass fibre filters (presoaked in 0J % PEI for at least 6 h) under suction and immediately washed with 2 x 5 ml ice-cold buffer. The amount of radioactivity on the filters is determined by conventional liquid scintillation counting. Specific binding is total binding minus non-specific binding. In vitro inhibition of 3 H-epibatidin binding Epibatidin is an alkaloid that was first isolated from the skin of the Ecuadoran frog Epipedobates tricolor and was found to have very high affinity for neuronal nicotinic receptors, where it acts as a potent agonist. 3 H-epibatidin binds to two sites in rat brain, both of which have pharmacological profiles consistent with neuronal nicotinic receptors and a similar brain regional distribution (Hougling et al., Mol. Pharmacol. 48, 280-287 (1995)). The high affinity binding site for H-epibatidin is most certainly binding to the o 4 β 2 subtype of nicotinic receptors. The identity of the low affinity site is still unknown; does it represent a second nicotinic receptor or a second site in the same receptor. The inability of α-bungarotoxin to compete for 3 H-epibatidin binding sites indicates that neither site measured represents the nicotinic receptor composed of α 7 subunits. Tissue preparation: Preparations are performed at 0-4°C unless otherwise indicated. The forebrain (÷cerebellum) from a male Wistar rat (150-250 g) is homogenized for 10- 20 sec in 20 ml Tris, HCI (50 mM, pH 7.4) using an Ultra-Turrax homogenizer. The tissue suspension is centrifuged at 27,000 x g for 10 min. The supernatant is discarded and the pellet is washed three times by centrifugation at 27,000 x g for 10 min in 20 ml fresh buffer, and the final pellet is resuspended in fresh buffer (400 ml per g of original tissue) and used for binding assays. Assay: Aliquots of 2.0 ml homogenate are added to 0J00 ml of test solution and 0J00 ml of 3 H-epibatidin (0.3 nM, final concentration), mixed and incubated for 60 min at room temperature. Non-specific binding is determined using (-)-nicotine (30 μM, final concentration). After incubation the samples are poured directly onto Whatman GF/C glass fibre filters (presoaked in 0.1% PEI for at least 20 min) under suction and immediately washed with 2 x 5 ml ice-cold buffer. The amount of radioactivity on the filters is determined by conventional liquid scintillation counting. Specific binding is total binding minus non-specific binding. Results are given as IC 50 values; the concentration (μM) that inhibit binding of the radioactive ligand by 50 %. Below test results for compounds of the invention are presented: (Compound numbers refers to the examples) Pharmaceutical Compositions In another aspect the invention provides novel pharmaceutical compositions comprising a therapeutically effective amount of the chemical compound of the invention. While a chemical compound of the invention for use in therapy may be administered in the form of the raw chemical compound, it is preferred to introduce the active ingredient, optionally in the form of a physiologically acceptable salt, in a pharmaceutical composition together with one or more adjuvants, excipients, carriers and/or diluents. In a preferred embodiment, the invention provides pharmaceutical compositions comprising the chemical compound of the invention, or a pharmaceutically acceptable salt or derivative thereof, together with one or more pharmaceutically acceptable carriers therefor and, optionally, other therapeutic and/or prophylactic ingredients. The carrier(s) must be "acceptable" in the sense of being compatible with the other ingredients of the formulation and not deleterious to the recipient thereof. Pharmaceutical compositions of the invention may be those suitable for oral, rectal, nasal, topical (including buccal and sub-lingual), transdermal, vaginal or parenteral (including intramuscular, sub-cutaneous and intravenous) administration, or those in a form suitable for administration by inhalation or insufflation. The chemical compound of the invention, together with a conventional adjuvant, carrier, or diluent, may thus be placed into the form of pharmaceutical compositions and unit dosages thereof, and in such form may be employed as solids, such as tablets or filled capsules, or liquids such as solutions, suspensions, emulsions, elixirs, or capsules filled with the same, all for oral use, in the form of suppositories for rectal administration; or in the form of sterile injectable solutions for parenteral (including subcutaneous) use. Such pharmaceutical compositions and unit dosage forms thereof may comprise conventional ingredients in conventional proportions, with or without additional active compounds or principles, and such unit dosage forms may contain any suitable effective amount of the active ingredient commensurate with the intended daily dosage range to be employed. The chemical compound of the present invention can be administered in a wide variety of oral and parenteral dosage forms. It will be obvious to those skilled in the art that the following dosage forms may comprise, as the active component, either a chemical compound of the invention or a pharmaceutically acceptable salt of a chemical compound of the invention. For preparing pharmaceutical compositions from a chemical compound of the present invention, pharmaceutically acceptable carriers can be either solid or liquid. Solid form preparations include powders, tablets, pills, capsules, cachets, suppositories, and dispersible granules. A solid carrier can be one or more substances which may also act as diluents, flavouring agents, solubilizers, lubricants, suspending agents, binders, preservatives, tablet disintegrating agents, or an encapsulating material. In powders, the carrier is a finely divided solid which is in a mixture with the finely divided active component. In tablets, the active component is mixed with the carrier having the necessary binding capacity in suitable proportions and compacted in the shape and size desired. The powders and tablets preferably contain from five or ten to about seventy percent of the active compound. Suitable carriers are magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose, a low melting wax, cocoa butter, and the like. The term "preparation" is intended to include the formulation of the active compound with encapsulating material as carrier providing a capsule in which the active component, with or without carriers, is surrounded by a carrier, which is thus in association with it. Similarly, cachets and lozenges are included. Tablets, powders, capsules, pills, cachets, and lozenges can be used as solid forms suitable for oral administration. For preparing suppositories, a low melting wax, such as a mixture of fatty acid glyceπ ' des or cocoa butter, is first melted and the active component is dispersed homogeneously therein, as by stirring. The molten homogenous mixture is then poured into convenient sized moulds, allowed to cool, and thereby to solidify. Compositions suitable for vaginal administration may be presented as pessaries, tampons, creams, gels, pastes, foams or sprays containing in addition to the active ingredient such carriers as are known in the art to be appropriate. Liquid preparations include solutions, suspensions, and emulsions, for example, water or water-propylene glycol solutions. For example, parenteral injection liquid preparations can be formulated as solutions in aqueous polyethylene glycol solution. The chemical compound according to the present invention may thus be formulated for parenteral administration (e.g. by injection, for example bolus injection or continuous infusion) and may be presented in unit dose form in ampoules, pre-filled syringes, small volume infusion or in multi-dose containers with an added preservative. The compositions may take such forms as suspensions, solutions, or emulsions in oily or aqueous vehicles, and may contain formulatory agents such as suspending, stabilising and/or dispersing agents. Alternatively, the active ingredient may be in powder form, obtained by aseptic isolation of sterile solid or by lyophilisation from solution, for constitution with a suitable vehicle, e.g. sterile, pyrogen-free water, before use. Aqueous solutions suitable for oral use can be prepared by dissolving the active component in water and adding suitable colorants, flavours, stabilising and thickening agents, as desired. Aqueous suspensions suitable for oral use can be made by dispersing the finely divided active component in water with viscous material, such as natural or synthetic gums, resins, methylcellulose, sodium carboxymethylcellulose, or other well known suspending agents. Also included are solid form preparations which are intended to be converted, shortly before use, to liquid form preparations for oral administration. Such liquid forms include solutions, suspensions, and emulsions. These preparations may contain, in addition to the active component, colorants, flavours, stabilisers, buffers, artificial and natural sweeteners, dispersants, thickeners, solubilizing agents, and the like. For topical administration to the epidermis the chemical compound according to the invention may be formulated as ointments, creams or lotions, or as a transdermal patch. Ointments and creams may, for example, be formulated with an aqueous or oily base with the addition of suitable thickening and/or gelling agents. Lotions may be formulated with an aqueous or oily base and will in general also contain one or more emulsifying agents, stabilising agents, dispersing agents, suspending agents, thickening agents, or colouring agents. Compositions suitable for topical administration in the mouth include lozenges comprising the active agent in a flavoured base, usually sucrose and acacia or tragacanth; pastilles comprising the active ingredient in an inert base such as gelatin and glycerine or sucrose and acacia; and mouthwashes comprising the active ingredient in a suitable liquid carrier. Solutions or suspensions are applied directly to the nasal cavity by conventional means, for example with a dropper, pipette or spray. The compositions may be provided in single or multi-dose form. In the latter case of a dropper or pipette, this may be achieved by the patient administering an appropriate, predetermined volume of the solution or suspension. In the case of a spray, this may be achieved for example by means of a metering atomising spray pump. Administration to the respiratory tract may also be achieved by means of an aerosol formulation in which the active ingredient is provided in a pressurised pack with a suitable propellant such as a chlorofluorocarbon (CFC) for example dichlorodifluoromethane, trichlorofluoromethane, or dichlorotetrafluoroethane, carbon dioxide, or other suitable gas. The aerosol may conveniently also contain a surfactant such as lecithin. The dose of drug may be controlled by provision of a metered valve. Alternatively the active ingredients may be provided in the form of a dry powder, for example a powder mix of the compound in a suitable powder base such as lactose, starch, starch derivatives such as hydroxypropylmethyl cellulose and polyvinylpyrrolidone (PVP). Conveniently the powder carrier will form a gel in the nasal cavity. The powder composition may be presented in unit dose form for example in capsules or cartridges of, e.g., gelatin, or blister packs from which the powder may be administered by means of an inhaler. In compositions intended for administration to the respiratory tract, including intranasal compositions, the compound will generally have a small particle size for example of the order of 5 microns or less. Such a particle size may be obtained by means known in the art, for example by micronization. When desired, compositions adapted to give sustained release of the active ingredient may be employed. The pharmaceutical preparations are preferably in unit dosage forms. In such form, the preparation is subdivided into unit doses containing appropriate quantities of the active component. The unit dosage form can be a packaged preparation, the package containing discrete quantities of preparation, such as packaged tablets, capsules, and powders in vials or ampoules. Also, the unit dosage form can be a capsule, tablet, cachet, or lozenge itself, or it can be the appropriate number of any of these in packaged form. Tablets or capsules for oral administration and liquids for intravenous administration and continuous infusion are preferred compositions. The dose administered must of course be carefully adjusted to the age, weight and condition of the individual being treated, as well as the route of administration, dosage form and regimen, and the result desired. It is presently contemplated that compositions containing of from about OJ to about 500 mg of active ingredient per unit dosage, preferably of from about 1 to about 100 mg, most preferred of from about 1 to about 10 mg, are suitable for therapeutic treatments. A satisfactory result can, in certain instances, be obtained at a dosage as low as 0.005 mg/kg i.v. and 0.01 mg/kg p.o. The upper limit of the dosage range is about 10 mg/kg i.v. and 100 mg/kg p.o. Preferred ranges are from about 0.001 to about 1 mg/kg i.v. and from about 0J to about 10 mg/kg p.o. Method of Treating The compounds of the present invention are valuable nicotinic ACh receptor modulators and therefore useful for the treatment of a range of ailments involving cholinergic dysfunction as well as a range of disorders responsive to the activity of nicotinic ACh receptor modulators. The compounds may be used in the treatment, prevention, profylaxis or alleviation of a disease, disorder or condition of the central nervous system as for example: neurodegenerative disorders, cognitive or memory dysfunction, Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic Lateral Sclerosis, Gilles de la Tourettes syndrome, attention deficit hyperactivity disorder, anxiety, depression, mania, manic depression, schizophrenia, obsessive compulsive disorders, eating disorders like anorexia nervosa, bulimia and obesity, narcolepsy, nociception, memory loss, memory dysfunction, AIDS-dementia, senile dementia , peripherial neuropathy, learning deficit, cognition deficit, attention deficit, autism, dyslexia, tardive dyskinesia, hyperkinesia, epilepsy, bulimia, post- traumatic syndrome, social phobia, chronic fatigue syndrome, disorders of sleep, pseudodementia, Ganser's syndrome, prementraul syndrome, late luteal phase syndrome, chronic fatigue syndrome, premature ejaculation, erectile difficulty, mutism and trichotillomania. The compounds of this invention may also be used in the treatment of inflammatory conditions as for example: inflammatory skin conditions like acne and rosacea, Chron's disease, inflammatory bowel disease, ulcerative collitis, diarrhoea. Also the compounds of the invention may be used in the treatment of diseases associated with smooth muscle contractions as for example: convulsive disorders, angina pectoris, premature labor, convulsions, diarrhoea, asthma, epilepsy, tardive dyskinesia, hyperkinesia. The compounds of this invention may also be used in the treatment of pain as for example chronic, acute and recurrent pain, postoperative pain, migraine pain or phantom limb pain; The compounds of the present invention may also be used for the assistance in cessation of abuse of chemical substances as for example smoking cessation as well as cessation of use of other nicotine containing products, cessation of use of opiods like heroin, cocaine and morphine and cessation of use of benzodiazepines or alcohol. In the context of the present invention "treatment" means as well treatment as prevention, profylaxis and alleviation of withdrawal symptoms and abstinence as well as treatment resulting in a voluntary diminished intake of the addictive substance. Suitable dosage range are OJ-500 milligrams daily, and especially 10-70 milligrams daily, administered once or twice a day, dependent as usual upon the exact mode of administration, form in which administered, the indication toward which the administration is directed, the subject involved and the body weight of the subject involved, and further the preference and experience of the physician or veterinarian in charge. I. p. means intraperetoneally, which is a well known route of administration. P.o. means peroral, which is a well known route of administration. The following examples will illustrate the invention further, however, they are not to be construed as limiting. Examples General: All reactions involving air sensitive reagents or intermediates were performed under nitrogen and in anhydrous solvents. Magnesium sulfate was used as drying agent in the workup-procedures and solvents were evaporated under reduced pressure. 5 1 -Aza-1 -chlorooctane To an aqueous solution of sodium hypochlorite (4 %, 500 ml) was added to azacyclooctane (20.0 g, 177 mmol) dropwise at 10 °C. The mixture was stirred for 5 min at 10 °C, followed by extraction four times with ethyl ether (60 ml). The crude product was purified by destination 34- 10 36 °C, 1 mm Hg. Yield 17.2 g, 69 %. 1-Aza-oct-1-en A mixture of 1 -aza-1 -chloroctane (17.2 g, 121 mmol), potassium superoxide (19.0 g, 267 mmol), 18-crown-6-ether (0.25 g , 0.95 mmol) was stirred at room temperature over night. 15 3-Bromo-5-thioethoxypyridine A mixture of sodium thioethoxide (5.86 g, 69.6 mmol), 3.5-Dibromopyridine (15.0 g, 63.3 mmol) and dimethyl sulfoxide (75 ml). The mixture was stirred at 90 °C for 2 h. Sodium hydroxide (300 ml, 1 M) was added and the mixture was extracted twice with diethyl ether (100 20 ml). Chromatography on silica gel with dichloromethane eluent gave the title compound as an oil. Yield 8.55 g, 58 %. 3-Bromo-6-thioethoxypyridine A mixture of sodium thioethoxide (7.81 g, 92.9 mmol), 2.5-Dibromopyridine (20.0 g, 84.4 25 mmol) and dimethyl sulfoxide (100 ml). The mixture was stirred at 20 °C overnight. Sodium hydroxide (300 ml, 1 M) was added and the mixture was extracted twice with diethyl ether (200 ml). Chromatography on silica gel with dichloromethane : petroleum ether, 1 :2 as eluent, gave the title compound as an oil. Yield 16.8 g, 85 %. 30 Method A 1a: (R,S)-1-H-2-(3-pyridyl)azacyclooctane fumaric acid salt Tert-butyllithium (142.8 ml, 242.8 mmol) was added to 3-Bromopyridine (19.2 g, 121.4 mmol) in anhydrous diethyl ether at -85- (-95) °C. The mixture was stirred for 0.5 h at -95 °C. A crude 35 mixture of 1 -aza-oct-1 -en was filtered under inert atmosphere followed by anhydrous diethyl ether, and the filtrate was added to the reaction mixture at -90 - (-95) °C. The mixture was stirred for 0.5 h at -90 °C. The temperature was allowed to reach -40 °C and water (15 ml) was added slowly. The reaction mixture was allowed to reach room temperature and stir for 15 h. Sodium hydroxide (200 ml, 0.5 M) was added and the phases were separated. The water phase was extracted three times with diethyl ether. The collected organic phases were purified by chromatography on silica gel with dichloromethane and ethanol (9:1 ) as solvent. Yield 12.6 g, 54 %. The corresponding salt was obtained by addition of a diethyl ether and methanol mixture (9:1) saturated with fumaric acid. Mp 141 -142 °C. 2a: (R,S)-1-H-2-(3-pyridyl)azacycloheptane fumaric acid salt Prepared according to method A. Mp 130-131 °C. Known in the literature Tetrahedron Lett., 1901 (1978). 3a: (R,S)-1-H-2-(3-quinolinyl)azacyclooctane fumaric acid salt Prepared according to method A. Mp 172-174 °C 4a: (R,S)-1-H-2-(6-thioethyl-3-pyridyl)azacycloheptane fumaric acid salt Prepared according to method A. Mp 140-142 °C. 5a:(R,S)-1-H-2-(5-thioethyl-3-pyridyl)azacycloheptane fumaric acid salt Prepared according to method A. Mp 159-161 °C. 6a:(R,S)-1-H-2-(5-thioethyl-3-pyridyl)azacyclooctane Prepared according to method A. Isolated as an oil. Method B 1 b:(R,S)-1-Methyl-2-(3-pyridyl)azacyclooctane A mixture of (R,S)-1 -H-2-(3-pyridyl)azacyclooctane (4.0 g, 21.0 mmol), formaldehyde (6.3 g, 37 %) and formic acid (10.6 g, 88 %) was refluxed for 16 h. The mixture was evaporated to dryness and sodium hydroxide (50 ml) was added followed by extraction twice with ethyl acetate (30 ml). The product was isolated as an oil. Yield 4.0 g, 93 %. 2b:(R,S)-1-Methyl-2-(3-quinolinyl)azacyclooctane Prepared according to method B. Isolated as an oil 3b: (R,S)-1 -Methyl-2-(6-thioethyl-3-pyridyl)azacycloheptane Prepared according to method B. Isolated as an oil. 4b: (R,S)-1-Methyl-2-(5-thioethyl-3-pyridyl)azacycloheptane Prepared according to method B. Isolated as an oil. 5b:(R,S)-1-Methyl-2-(5-thioethyl-3-pyridyl)azacyclooctane fumaric acid salt Prepared according to method B. Mp 143.5-145.5 °C. Method C 1 c: 2-(3-Pyridyl)azacyclooct-1-ene (R,S)-1-H-2-(3-pyridyl)azacycloctane (2.0 g, 10.5 mmol) was added dropwise to an aqueous solution of sodium hypochlorite (90 ml, 47.3 mmol) at 10 °C and stirred for 5 min. The mixture was extracted three times with dichloromethane (30 ml). The crude product, dried overnight under vacuum and sodium hydroxide: (R,S)-1-chloro-2-(3-pyridyl)-azacyclooctane (2J g, 9.3 mmol) was mixed with potassium superoxide (1.46 g, 20.6 mmol) and 18- crown-6-ether (0.30 g, 1.1 mmol) in tetrahydrofuran and stirred at room temperature for two days. Aqueous sodium hydroxide (100 ml, 1 M) was added, the mixture was extracted twice with ethyl acetate (40 ml) The crude product was purified by chromatography on silica gel with dichloromethane and ethanol and concentrated ammonia (89:9:1) as solvent. The title compound was isolated as an oil, yield 0.40 g, 23 %. 2c: 2-(3-Quinolinyl)azacyclooct-1-ene fumaric acid salt Prepared according to method C. Mp 169-171 °C 3c: 2-(5-thioethyl-3-pyridyl)azacyclooct-1 -ene Prepared according to method C.

Claims: Claims: 1. A compound having the formula, 1 2 any of its enantiomers or any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein n is 0, or 1 ; R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl; and R 1 is aryl which may be substituted one or more times with substituents selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl alkenyl, alkynyl, alkoxy, thioalkoxy, cycloalkoxy, thiocycloalkoxy, methylenedioxy, aryloxy, halogen, CF 3 , OCF 3 , CN, amino, nitro, aryl and a monocyclic 5 to 6-membered heteroaryl group; or a monocyclic 5 to 6-membered heteroaryl group which may be substituted one or more times with substituents selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl alkenyl, alkynyl, alkoxy, thioalkoxy, thiocycloalkoxy, methylenedioxy, aryloxy cycloalkoxy, halogen, CF 3 , OCF 3 , CN, amino, nitro, aryl and a monocyclic 5 to 6-membered heteroaryl group; or a bicyclic heteroaryl group composed of a monocyclic 5 to 6 membered heteroaryl group fused to a benzene ring and which may be substituted one or more times with substituents selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl alkenyl, alkynyl, alkoxy, thioalkoxy, thiocycloalkoxy cycloalkoxy, methylenedioxy, aryloxy, halogen, CF 3 , OCF 3 , CN, amino, nitro, aryl and a monocyclic 5 to 6 membered heteroaryl group, provided however that the compound is not 7-phenyl-3,4,5,6-tetrahydro-2H-Azepine; hexahydro-2-phenyl-1 H-azepine; 1 -n-butylhexahydro-2-phenyl-1 H-azepine; hexahydro-2-(R)-phenyl-1 H-azepine; hexahydro-2-(3-pyridinyl)-1 H-azepine; 3,4,5,6-tetrahydro-7-(3-pyridinyl)-2H-azepine; hexahydro-1 -methyl-2-phenyl-1 H-azepine; octahydro-1 -methyl-2-phenyl-azocine; hexahydro-1 -methyl-2-(S)-(3-pyridinyl)-1 H-azepine; 7-(3,4-dimethoxyphenyl)-3,4,5,6-tetrahydro-2H-azepine; 2-(3,4-dimethoxyphenyl)hexahydro-1 H-azepine; or hexahydro-2-(methylphenyl)-1 H-azepine; 2. A compound of claim 1 formulas 1 and 2 wherein n is 0, or 1 ; R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl; and R 1 is aryl which is substituted one or more times with substituents selected from the group consisting of cycloalkyl, cycloalkylalkyl alkenyl, alkynyl, thioalkoxy, cycloalkoxy, thiocycloalkoxy, methylenedioxy, aryloxy, halogen, CF 3 , OCF 3 , CN, amino, nitro, aryl and a monocyclic 5 to 6-membered heteroaryl group; a monocyclic 5 to 6-membered heteroaryl group which may be substituted one or more times with substituents selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl alkenyl, alkynyl, alkoxy, thioalkoxy, thiocycloalkoxy, methylenedioxy, aryloxy cycloalkoxy, halogen, CF 3 , OCF 3 , CN, amino, nitro, aryl and a monocyclic 5 to 6-membered heteroaryl group; or a bicyclic heteroaryl group composed of a monocyclic 5 to 6 membered heteroaryl group fused to a benzene ring and which may be substituted one or more times with substituents selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl alkenyl, alkynyl, alkoxy, thioalkoxy, thiocycloalkoxy cycloalkoxy, methylenedioxy, aryloxy, halogen, CF 3 , OCF 3 , CN, amino, nitro, aryl and a monocyclic 5 to 6 membered heteroaryl group; provided that the compound is not: hexahydro-2-(3-pyridinyl)-1 H-azepine or hexahydro-1 -methyl-2-(S)-(3-pyridinyl)-1 H-azepine; 3. A compound of claim 1 formula 1 or 2, wherein n is 0, or 1 ; R is hydrogen or methyl and R 1 is 3-pyridyl, 3-quinolinyl, 6-thioethyl-3-pyridyl or 5-thioethyl-3-pyridyl; 4. A compound of claim 1 to 3 which is (R,S)-1-H-2-(3-pyridyl)azacyclooctane; (R,S)-1-H-2-(3-quinolinyl)azacyclooctane; (R,S)-1-H-2-(6-thioethyl-3-pyridyl)azacycloheptane; (R,S)-1-H-2-(5-thioethyl-3-pyridyl)azacycloheptane (R,S)-1-H-2-(5-thioethyl-3-pyridyl)azacyclooctane; (R,S)-1-Methyl-2-(3-quinolinyl)azacyclooctane; R,S)-1 -Methyl-2-(6-thioethyl-3-pyridyl)azacycloheptane; (R,S)-1-Methyl-2-(5-thioethyl-3-pyridyl)azacycloheptane; (R,S)-1-Methyl-2-(5-thioethyl-3-pyridyl)azacyclooctane; 2-(3-Pyridyl)azacyclooct-1 -ene; 2-(3-Quinolinyl)azacyclooct-1 -ene; or 2-(5-Thioethyl-3-pyridyl)azacyclooct-1 -ene; or a pharmaceutically acceptable addition salt thereof. 5. A pharmaceutical composition, comprising a therapeutically effective amount of a compound of any of the claims 1 to 4, or a pharmaceutically acceptable addition salt thereof, together with at least one pharmaceutically acceptable carrier or diluent. 6. The use of a compound according to any of the claims 1 to 4 for the manufacture of a medicament for the treatment of a disease of a living animal body, including a human, which disease is responsive to the activity of nicotinic ACh receptor modulators. 7. The use according to claim 6 wherein the disease to be treated is pain, a disease in the central nervous system, a disease caused by smooth muscle contraction, neurodegeneration, inflammation, chemical substance abuse or withdrawal symptoms caused by the cessation of intake of the chemical substance. 5 8. The use of a compound according to claim 7 wherein the disease to be treated is a disease in the central nervous system said disease being Alzheimer's disease, Parkinson's disease, memory dysfunction or attention deficit hyperactivity disorder. 10 9. The use according to claim 7 wherein the disease to be treated is chemical substance abuse or withdrawal symptoms caused by the cessation of intake of the chemical substance, said chemical substance abuse being smoking or use of other nicotine containing products and withdrawal symptoms caused by cessation of use of nicotine containing products; 15 10. A method for the preparation of the compounds according to any of the claims 1 to 4 comprising the step of a) reacting a compound having the formula wherein n is as defined above, with a compound of the formula R 1 -Li, wherein R 1 is as defined above; to form a compound of formula 25 wherein n and R 1 is as defined above, or b) oxidising a compound having the formula wherein R 1 and n is as defined above, to form a compound having the formula wherein R 1 and n is as defined above. 11. A method of treating a disease of a living animal body, including a human, which disease is responsive to the activity of nicotinic ACh receptor modulators, comprising the step of administering to such a living animal body, including a human, in need thereof a therapeutically effective amount of a compound according to any of the claims 1 to 4. 12. The method according to claim 11 , wherein pain, a disease in the central nervous system, a disease caused by smooth muscle contraction, neurodegeneration, inflammation, chemical substance abuse or withdrawal symptoms caused by the cessation of intake of the chemical substance, is treated; 13. The method according to claim 12 wherein chemical substance abuse or withdrawal symptoms caused by the cessation of intake of the chemical substance, said chemical substance abuse being smoking or use of other nicotine containing products and withdrawal symptoms caused by cessation of use of nicotine containing products, is treated; 14. The method of claim 12 wherein a disease in the central nervous system, said disease being Alzheimer's disease, Parkinson's disease, memory dysfunction or attention deficit hyperactivity disorder, is treated.

Inventors: NIELSEN ELSEBET OESTERGAARD, NIELSEN SIMON FELDBAEK, OLSEN GUNNAR M, PETERS DAN, NIELSEN, ELSEBET, OESTERGAARD, NIELSEN, SIMON, FELDBAEK, OLSEN, GUNNAR, M., PETERS, DAN
Applicants: NEUROSEARCH AS, NIELSEN ELSEBET OESTERGAARD, NIELSEN SIMON FELDBAEK, OLSEN GUNNAR M, PETERS DAN, NEUROSEARCH A/S, NIELSEN, ELSEBET, OESTERGAARD, NIELSEN, SIMON, FELDBAEK, OLSEN, GUNNAR, M., PETERS, DAN
Application year: 1998
Main classification: C07D223
IPC codes: A61K31, A61P21, A61P25, A61P29, A61P43, C07D223, C07D225, C07D401