COMPUTER-AIDED DIAGNOSIS SYSTEM AND METHOD

Abstract: X-ray images (10) are displayed on a light box (100) together with annotated road maps of CAD-detected abnormalities and with further processed images of the areas around the CAD detected abnormalities which are displayed on one or more small TV monitors (200) located in close proximity to the light box so that the physician can better assess the level and significance of these detected abnormalities in the x-ray images.

Description: COMPUTER-AIDED DIAGNOSIS SYSTEM AND METHOD Reference to Related Applications This application is a continuation-in-part of copending parent applications Serial Nos. 08/579,802 filed on December 28, 1995 and 08/438,432 filed on May 10, 1995 (allowed). In turn, Serial No. 08/579,802 is a continuation, and Serial No. 08/438,432 is a continuation-in- part, of parent application Serial No. 08/129,255 filed on September 29, 1993 (abandoned). This application hereby incorporates by reference the entire disclosure, drawings and claims of each of said parent applications as though fully set forth herein. Field and Background of the Invention This invention relates to displaying radiological images and other information in a manner which is believed to assist users such as physicians in reading such images and other information. More specifically, the invention relates to a computer-aided diagnosis ("CAD") system and method for detection and identification of abnormalities from radiological images which can be viewed in a conventional format but in conjunction with viewing an annotated road map of the location and or the identification of suspected abnormalities found in accordance with the invention through computer processing of the conventionally obtained radiological image. The annotated map highlights and/or identifies suspected abnormalities to help the reader better assess the presence and/or meaning and significance of abnormalities in the conventionally obtained radiological image. The detection of abnormal anatomic regions in radiological images using a computer system comprising specialized software and possibly specialized hardware has been reported. For example, in the area of mammography, representative reports are: Gager et al in the May 1993 issue of RadioGraphics, pages 647-656; Giger et al in Proceedings of SPIE, Volume 1445 (1991), pages 101-103; Doi et al in U.S. Patent No. 4,907,156: and Giger et al in U.S. Patent No. 5,133,020. See, also, the disclosure of and in prior art cited in said parent applications. In particular, in the area of detecting spiculated or stellate lesions in applications. In particular, in the area of detecting spiculated or stellate lesions in mammograms using convergent line detectors as the principal abnormal feature detection algorithm, representative reports are: N. Karssemeijer in the book entitled "Digital Mammography", edited by A. G. Gale et al, published by Elsevier in 1994, pages 21 1-219; and Kegelmeyer et al in Volume 191 (1994) of Radiology, pages 331-337. In the area of detecting clusters of microcalcifications in mammograms using thresholding and a clustering kernel as the principal abnormal feature detection algorithm, representative report are: Nishikawa et al in Volume 20 (1993) of Medical Physics, pages 1661-1666; and Feig et al in Volume 33 (1995) of Radiological Clinics of North America, pages 1205-30. See. also, copending patent applications Serial No. 08/676,660 filed on July 10, 1966 entitled '"Method and apparatus for fast detection of spiculated lesions in digital mammograms,' * and Serial No. 08/901,541 filed on July 28, 1997 entitled "Method and system for using local attenuation in the detection of abnormalities in digitized medical images." These two patent applications and each of the other references cited in this patent specification are incorporated herein by reference as though fully set forth herein. These systems are generally referred to as Computer-Aided Diagnosis ("CAD") systems, and are believed to be particularly useful to radiologists in the diagnostic process and particularly in screening radiological procedures. In a screening radiological procedure, such as screening mammography, the patients typically are asymptomatic and true abnormalities (e.g. cancers) are said to occur at a typical rate of about one case per one hundred patient examinations. Reading of the mammograms, when most of them are negative, can be a tedious task that can make it difficult to maintain a constantly high attention level. Some detectable abnormalities can be missed or misdiagnosed, which can result in delayed or more costly treatment, and can even result in a reduction of patient's longevity or chance of survival. According to an article in the May 26, 1993 issue of JAMA, pages 2616-2617, the misdiagnosis rate in mammograms can be in the range of 15 to 63%. The CAD system, serving as an electronic reminder or second reader, as a spell-checker can be in a word processor, can assist radiologists in attaining higher detection rate (higher sensitivity) for abnormalities or reducing the misdiagnosis rate (lowering the false-negative rate). Applicant understands that a current procedure using a CAD mammographic system proceeds as follows. The physician views a radiological image, reaches a preliminary diagnostic decision, and then views a separate second image displayed on a CAD system. This second image is marked or annotated with a localized identification of the abnormalities that the CAD system has detected through computer analysis of a digitized version of the conventionally obtained radiological image. After a reexamination the area of the radiological image that corresponds to the position of the detected abnormalities displayed on the CAD system, the physician makes the final diagnostic decision. This final diagnostic decision may or may not be the same as the preliminary decision, depending on whether the physician found the additional diagnostic information provided by the CAD system to be significant and, if so, what significance the physician ascribed to it. Following the final diagnostic decision, and perhaps depending on the degree of suspicion for malignancy, the physician can recommend a course of further action, which can include no further action or further follow-up examinations or biopsy. In the process of detecting abnormal anatomic features in radiological images using a CAD system as described in the above cited references, the radiological film image of a patient is processed through a film digitizer to generate a digitized image which is input as such into the system. The digitized image is then analyzed by a digital image processing computer with specialized software and perhaps also specialized hardware for abnormal anatomic feature detection. If abnormalities are detected, an annotated radiological image is displayed on a special TV monitor, with markers placed around or adjacent the detected abnormalities. This TV monitor typically has a large dimension (typically a screen diagonal of 12 inches or larger) and a high spatial resolution (typically more than 1000 x 1000 pixels). Because of the large dimension and high spatial resolution, this TV monitor typically is positioned at some distances away from the film. Typically the center of the monitor is more than 12 inches from the center of the film on the conventional film illumination box. In addition, this special TV monitor typically has a low brightness and a high cost. While the above described CAD system can point oυt the CAD-detected abnormalities to the physician, it is believed that the display method that it utilizes, using a high-resolution TV monitor, has certain shortcomings which make the process of using it inconvenient and inefficient. The high-resolution TV monitor is expensive, its spatial resolution although high for monitors is still much less than that of the original x-ray film, and its brightness and dynamic range are also very much inferior to those of an x-ray film viewed on a light box. Therefore, it is believed that a physician would not rely solely on the image displayed on the TV monitor to make diagnosis, but typically would repeatedly go back to the conventional film illumination box to view the original film image. This can lead to the loss of valuable time and can be uncomfortable at least because of the different brightness levels and spatial resolution levels of the two images. In addition, it is believed that diagnostic errors can arise from the need for the physician to shuttle back and forth between two different displayed images. Even when a potentially true abnormality (cancer) is detected and pointed out by the CAD system to the physician, the fatigue and eye discomfort and other effects due to viewing two images of such different characteristics may still cause the physician to miss the significance of the corresponding area on the original x-ray film and to fail to notice or appreciate the abnormal features of the detected abnormality and decide to ignore the detected abnormality. Summary of the Invention An object of the invention is to provide an improved combined display of an x-ray radiological image and CAD-detected abnormalities from the x-ray image. A more specific object is to provide the CAD user with further processed, annotated and enhanced image tiles of the regions around the CAD detected abnormalities for the purpose of emphasizing the abnormal image features of these detected abnormalities so that the user (physician) can better assess the type and degree of abnormality of these detected abnormalities in the radiological image. Another objective is to present the further processed image of the area around the CAD detected abnormalities on a small TV monitor located in such close proximity to the x-ray film during viewing of the x-ray film that eye and other discomfort due to viewing two different images alternately would be reduced. Still another object of the invention is to print the annotated road map and or the further processed image tiles of the area around the CAD detected abnormalities on the same sheet of photographic film that contains a printout of the radiological image. In an exemplary and non-limiting first embodiment of the invention, the further processed image of the area around the CAD detected abnormalities from a radiological film is presented on a small TV momtor, located in close proximity to the radiological film being viewed at the light box. The display of this further processed image shares (e.g., is toggled on) the small TN momtor with the display of a miniaturized annotated road map. On demand by the CAD user, e.g. the physician using a toggle switch, the miniaturized annotated road map image and the further processed image tiles of the areas around the CAD detected abnormalities are displayed alternatively on the small TV monitor. In another exemplary and non-limiting second embodiment of the invention, the miniaturized annotated road map image is presented on a small TN monitor and the further processed image tiles of the areas around the CAD detected abnormalities from a radiological film are presented on a second and separate small TV monitor, both located in close proximity to the radiological film being viewed at the light box. In the case of a radiological image that has been acquired through digital means, and thus is in digital form initially, the final image is frequently printed on a sheet of photographic film for later viewing on a light box. In an exemplary and non-limiting third embodiment of the invention, both a miniaturized annotation road map and the further processed image of the area around the CAD detected abnormalities from a radiological film are printed on the same sheet of photographic film that contains a print of the x-ray radiological image. In an exemplary and non-limiting fourth embodiment of the invention, a particularly simple digital radiography system comprises a CAD system and an analog acquisition system. In an exemplary and non-limiting fifth embodiment of the invention, a CAD system is used to decide how the relatively wide latitude digitally acquired image should be displayed on a display medium such as film having a narrower latitude. Brief Description of the Drawings Figure 1 is a block diagram illustrating a CAD system and its output display according to a first embodiment of the invention. Figure 2 is a block diagram illustrating a CAD system and its output display according to a second embodiment of the invention. Figure 3 is a block diagram illustrating a CAD system and a first method of output display according to the third embodiment of the invention. Figure 4 is a block diagram illustrating a CAD system and a second method of output display according to the third embodiment of the invention Figure 5 is a block diagram illustrating a CAD system and an output display according to a fourth embodiment of the invention. Figure 6 illustrates displaying an output according to a fifth embodiment of the invention. Detailed Description Referring to Figure 1 , a preferred but non-limiting example, according to a first embodiment of the invention, generates an annotated road map of CAD-detected abnormality and a further processed image of the area around the CAD detected abnormalities from a radiological film. Both the annotated road map and the further processed image are displayed on a small TV monitor located in close proximity to the radiological film being viewed at a light box. In this example, the radiological film is in the form of a mammographic x-ray film, which is acquired with a conventional mammographic film-screen imaging system. The original analog two-dimensional mammographic x-ray film 10. with a patient information label 12 printed on the edge of the film, is sent through a film digitizer 30 of a CAD (computer-aided diagnosis) system 20 (such as that disclosed in said U.S. patent applications which are incorporated by reference herein) to obtain a digitized two-dimensional mammographic image 40. Preferably, the film digitizer 30 should be a laser film digitizer or a high performance CCD based film digitizer and should have a dynamic range and a spatial resolution comparable to those of the original mammographic film which typically has a dynamic range of 10,000: 1 and spatial resolution of approximately 50 microns per pixel (or about 4,000 x 5,000 pixels for a 8-inch x 10-inch film). The identity of the original mammographic image 10 is entered into the CAD system at this point to identify the digitized mammographic image 40 and thus the original film 10. An useful option at this point is to automatically input the identity of this original mammographic image 10 into the CAD machine. This can be accomplished, for example, by labeling the mammographic film 10 with a code such as a bar code next to the a patient information label 12 printed on the edge of the film, or by incorporating the bar code into the patient information label 12. and then reading the label into the CAD system 20 with an optional ID bar code reader 15 as the mammographic film 10 is being fed into the film digitizer 30. The digitized mammographic image 40 is then sent through an abnormal feature detection stage 50 of the CAD system, or CAD machine, 20. The findings or results, positive or negative in nature, from the abnormal feature detection stage 50 are in the form of a two-dimensional annotation map 55, or x-y coordinate information, of the locations and types of the CAD-detected abnormalities 56 and 57 (in this illustrative example) present in the original film image 10. For the purpose of illustration, let the abnormality 56 be a spiculated lesion and let its location on the annotated map be marked with a star-shaped marker. Let the abnormality 57 be a cluster of microcalcifications and let its location on the annotated map be marked with a triangular shaped marker. Thus, the markers identify not only the detected location but also the detected nature of the suspected abnormality identified at this stage. The annotation map 55 can be scaled down to the same size of a sub-sampled image, say 512 x 512 pixel in size and 8-bit in gray scale, of the digitized image 40, and the two superimposed images in registration with each other forms a miniaturized annotated road map image 58. Enhanced image tiles 66 and 67, centered respectively around the CAD-detected abnormalities 56 and 57, say 512 x 512 pixel in size and 8-bit in gray scale, are generated by further image processing the regions in the digitized image 40 which correspond to the CAD detected abnormalities 56 and 57. The CAD-generated annotation map 55, the miniaturized annotated road map image 58, the enhanced image tiles 66 and 67, together with the digitized image 40 and its corresponding identification, may be stored for later use in an optional memory storage unit 70. The annotation road map 58 and the enhanced image tiles 66 and 67 are transferred to an output display section of the system for display. The output display section of the CAD system can be a part of the total CAD system, and in which case the data transfer is conducted through a dedicated shielded cable. Or, the output display section can be a separate system, in which case an additional data storage memory can be added to the unit to store the transferred interim data and the data transfer can be through a dedicated shielded cable or an existing network where the equipment is installed. It is important to point out and emphasize the abnormal features of the CAD detected abnormalities to the physician, because it is believed that the physician, even after seeing the location of the CAD detected abnormalities on the miniature road map 58, can fail to notice or appreciate these abnormal features on the original the x-ray film. By pointing these abnormal features out, with further emphasis, to the physician, it is believed that the physician would be in better position to assess the level of abnormality of these CAD detected abnormalities. The principal abnormal feature detection algorithms used in the abnormal feature detection stage 50 to detect the abnormalities can be used to further emphasize the abnormal features of the CAD detected abnormalities. For example, in the case of the abnormality 56, the principal abnormal feature used to detect the spiculated lesion can be a set of convergent lines. Since the presence of the convergent lines around a lesion raises the probability of malignancy, it is believed that there would be less a chance that the physician could ignore the lesion if the convergent lines were made more noticeable. Therefore, this set of convergent lines around the spiculated lesion could be contrast and edge enhanced to form the image tile 66. For example. Figure 3(B) of Karssemeijer article cited shows a set of detected pixels pointing to the center of a suspected spiculated lesion. Superimposing these detected pixels on the image can form the image tile 66. In the case of the abnormality 57, the principal abnormal feature used to detect the cluster of microcalcifications would be the small clustering of three or more high contrast spots. This small clustering of high contrast spots could be enhanced in brightness to form the image tile 67. The formation of this small clustering of bright spots can be of great interest to the physician. This is because the probability of malignancy is higher for a linear or branching formation. Therefore, this small clustering of high contrast spots should also be magnified in size, for example by a factor of 2 or more, to form the image tile 67 in order to help the physician see the formation of these bright spots clearly in the image tile 67. In this manner, it is believed that the CAD user, the physician, after seeing the enhanced abnormal image features of these detected abnormalities and reexamining the original x-ray image, can better assess the level of abnormality of these detected abnormalities in the x-ray image. Also shown in Figure 1 is an illustration of a CAD output display consisting of a conventional film illuminator, commonly called a light box, 100 and a small TV momtor 200 according to the first embodiment of the invention. In this exemplary embodiment, the miniaturized annotated road map 58 and the enhanced image tiles 66 and 67 are alternatively or sequentially displayed as images 300x. by operating a toggle switch 90 to display one image at a time (where x = a, b and c) on the small TV monitor 200 located in close proximity to the original film 10. Respectively, the image 300a represents the miniaturized annotated road map 58, the image 300b represents the enhanced image tile 66 around the CAD detected spiculated lesion, and the image 300c represents the enhanced image tile 67 around the CAD detected cluster of microcalcifications. If more abnormalities are detected, there would be images 300d.300e, etc. to be toggled through the small TV monitor. The dimension of the display screen of the small TV momtor 200 in this example of the invention are of the order of 1/4 to l A. of the dimension of original film 10. In addition, the small TV monitor 200 should be located as close as practical to the light box 100 displaying the original film 10. Preferably the center of the small TV momtor 200 should be less than 12 inches from the center of the original film 10 on the conventional film illumination light box 100. The preferred position, as shown in Figure 1, for mounting the small TV monitor 200 is just beneath the light box 100 which displays the original image 10. It is also convenient to display a pair of images on each TV monitor, since frequently a pair of the original mammographic films 10, such as the mammograms of the left and right breasts, are displayed and viewed next to each other. In this manner, the physician still has to minimally move his or her eyes back and forth between the onginal radiologic film image 10 oα the film illuminator 100 and the images 300x displayed on the small TV monitor 200. The spatial resolution of the small TV monitor 200 can be in the range of 500 TV lines, or comparable to that of NTSC or PAL. The brightness level of the small TV monitor 200 should be similar to that of the average brightness transmitted through the original film 10. so that the observer would not be bothered by a change in brightness. In using the CAD system as a second reader in a screening situation, it is sometimes preferred that the display on the small TV monitor 200 can be easily toggled with on-off with a switch 90 by the observer. Figure 2 is similar to Figure 1 in many respects, and similarly labeled components serve a similar function and therefore will not be described again in detail. Figure 2 shows a CAD output display comprising a conventional film illuminator 100 and, in this case, two small TV monitors 200 and 250, according to the second embodiment of the invention. In this exemplary embodiment, the annotated information 58 is presented as a miniaturized annotated road map image 300a on the first small TV momtor 200, located in close proximit to the original film 10. The enhanced image tiles 66 and 67 are alternatively or sequentially presented, by operating a toggle switch 90, as images 300b and 300c on the second small TV monitor 250. located next to the first small TV monitor 200 and in close proximity to the original film 10. It is sometimes preferred that two or more small TV monitors are used, in place of momtor 250, to display the further processed image tiles 66 and 67 such that each detected abnormality is displayed on a separate small TV momtor at the same time. The small TV monitors 200 and 250 can be placed at other positions relative to the light box 100, e.g. to the side or above light box 100. Referring to Figure 3, a preferred but non-limiting example according to the third embodiment of the invention receives radiological images which already are in the digital format, detects abnormalities on these radiological images with a CAD system, and prints out these radiological images together with CAD results on photographic film. Again, components labeled the same as in Figures 1 and 2 serve similar functions and therefore will not be described again in detail. Digital imaging systems, such as magnetic resonance imaging ("MRI") systems, computed tomography ("CT") systems, ultrasound imaging systems, scintillation cameras, computed radiography ("CR") systems (such as Fuji's CR system based on stimulated emission phosphor detector), and recently reported digital radiography and digital mammography systems (for example, see Feig article cited earlier; using CCDs or amorphous silicon array detectors), provide radiological images in the digital format. In this example, the radiological image is in the form of a digital mammogram, which is acquired with a digital mammography system. This digital mammogram 14. already having properly encoded identification and patient information 12, is reformatted into the digitized mammographic image 40 and is sent through the abnormal feature detection stage 50 of the CAD machine 20. If the information is already properly formatted for the CAD machine 20, it is sent directly to and through the abnormal feature detection stage 50 of the CAD machine 20 without reformatting. The initial film digitization step used in the first and second embodiments for analog mammograms is not needed in this case. As in the first and second embodiments, the findings or results, positive or negative in nature, from the abnormal feature detection stage 50 are in the form of a two-dimensional annotation map 55, or x-y coordinate information, of the locations and types of the CAD-detected abnormalities 56 and 57 from the original film image 10. For the purpose of illustration, let the abnormality 56 be a spiculated lesion and let its location on the annotated map be marked by a star shaped marker. Let the abnormality 57 be a cluster of microcalcifications and let its location on the annotated map be marked by a triangular shaped marker. The annotation map 55 can be scaled down to the same size of a sub-sampled image, say 512 x 512 pixel in size and 8-bit in gray scale, of the digitized image 40, and the two superimposed images in registration with each other form a miniaturized annotated road map image 58. Enhanced image tiles 66 and 67, centered respectively around the CAD-detected abnormalities 56 and 57, say 512 x 512 pixel in size and 8 -bit in gray scale, are generated by further image processing the regions in the digitized image 40 which correspond to the CAD detected abnormalities 56 and 57. The CAD-generated annotation map 55, the miniaturized annotated road map image 58, the enhanced image tiles 66 and 67, and together with the digitized image 40 and its corresponding identification, can be stored for later use in an optional memory storage unit 70. The annotation road map 58 and the enhanced image tiles 66 and 67 are transferred to the output display section of the system for display. There are several methods to display the CAD results and the digitally acquired mammogram. Since the digital system produces nυ film to start with at the acquisition, the first method is a totally filmless display by using a high resolution TV momtor 400. The resolution should be at least 1000 x 1000 pixels. In this method the annotation road map 58. the enhanced image tiles 66 and 67, and the digital mammogram 40 are all displayed on the same TV monitor as a combined digital image 450 as shown in Figure 3. The annotation road map 58 and the enhanced image tiles 66 and 67 are shown placed at the edge or margin of the combined digital image 450. Patient information 12 can also be displayed at the same edge or margin of the combined digital image 450. The annotation road map 58 may alternatively be displayed by overlaying it on top of the digital mammogram 40. This overlay may be toggled (switch not shown) on and off so that the digital mammogram 40 can be examined without obstruction. The enhanced image tiles 66 and 67 can also be toggled (switch not shown) on and off. The second method of display, shown in Figure 4, where the same reference numerals have the same significance as in the earlier Figures, makes a photographic film printout of the digital mammogram 40, the miniaturized annotation road map 58 and the enhanced image tiles 66 and 67 all on a same sheet of film 500. The printout film 500 is viewed on a light box 550. Since, at the present time, physicians usually are more accustomed to a photographic film, which conveys information with much higher resolution and gray scale than a high resolution TV monitor, the second method of display can be preferred over the first method of display. The annotation road map 58 and the enhanced image tiles 66 and 67 are shown in Figure 4 placed at the same edge or margin of the printout film as the patient information label 12. The photographic film printout, typically having a resolution of 4000 x 5000 pixels, can be made with a high resolution laser film printer 580. Such high resolution, 4000 x 5000 pixels, laser film printers are commercially available with a resolution of 40 microns per pixel for 8 inch x 10 inch size films and 100 microns per pixel for 14 inch x 17 inch size films. It is sometimes preferred that only the miniaturized annotation road map 58 be printed at the edge of the printout film 500. Digital radiological images, such as in the case of images from magnetic resonance imaging ("MRI"), computed tomography ("CT"), digital fluorography ("DF"), and computed radiography ("CR"), are sometimes printed out on sheets of 4000 x 5000 pixels photographic film for later viewing on a light box. Since MRI images are typically formatted into 256 x 256 pixels. CT images into 512 x 512 pixels. DF images into 1024 x 1024 pixels, and CR images into 2048 x 2048 pixels, many images from MRI or CT or CR modalities can be printed as small tiles in an array on one sheet of 4000 x 5000 pixels photographic film. Therefore, the CAD findings from these images can be printed as one or several of the tiles. A further refinement on the use of CAD is to reduce the number of images to be presented to the physician, for example by not presenting radiological images on which no suspected abnormalities are found by the CAD system, or by not presenting such radiological images for a second opinion or review by another professional. Although the embodiments discussed above have been described in terms of preferred structures involving a single sheet of film, it should be apparent to those skilled in the art that this invention applies to viewing of multiple films on a multiple-film viewing station or an alternator (a multiviewer having pre-loaded films and a transport belt), to allow several x-ray films 10 or printout films 500 to be viewed at the same time or different times, with or without their respective annotation maps 58 and the enhanced image tiles 66 and 67. Figure 5 illustrates a particularly efficient digital radiography system according to the fourth embodiment of the invention. Again, the same reference numerals have the same meanings as in the earlier Figures. The Figure 5 system comprises an analog film-screen acquisition system and a CAD system similar to the third embodiment. In this example, the radiological image is in form of a low contrast and wide latitude mammographic film 600. This embodiment and the third embodiment differ in the source of the digitized image 40. The acquisition system, in this case, is an inexpensive conventional mammographic intensifying screen cassette 620. The cost ratio between this screen cassette 620 and a typical current digital mammographic system is several order of magnitude, e.g., approximately 1000 times. The standard screen-film acquisition and exposure technique and the conventional mammographic x-ray system (not shown) will be unchanged for use in this embodiment of the invention. By reducing the contrast gradient G of the mammographic film 600 say from about 3.0 to about 2.0 to 1.5, we obtain a film with a factor of 5 to 25 more in latitude. That is, the exposure range expands from about 25 to about 125 to 630. The contrast gradient G is generally defined as the slope of the H & D [or film characteristics] curve where the optical density [or the log (base 10) of the reciprocal of the film transmission, the y-axis] is plotted against the log (base 10) of x-ray exposure [or light exposure, the x-axis]. Because of the low contrast, the physician cannot be expected to make diagnosis on this low contrast and wide latitude mammogram 600. However, this mammographic film 600 can be digitized through the film digitizer 30 and reformatted into a digitized image 40, and can be put through the CAD abnormal feature detection stage 50. The reformatted version of the wide latitude image 600 is fed through a high resolution film printer 580 and printed out as a conventional high contrast mammogram 650. Its respective annotated road maps 58 and the enhanced image tiles 66 and 67 are also printed at the edge or margin of the mammogram 650. The physician, as in the third embodiment, finally reads the mammogram on the light box 550. Using the miniaturized road map 58 as a guide, the physician reexamines the mammogram 650 to see if any of the CAD detected abnormalities suggest further action. The enhanced image tiles 66 and 67 provide the physician with further information by emphasizing the abnormal features of the CAD detected abnormalities. It is sometimes preferred that only the miniaturized annotation road map 58 be printed at the margin of the mammogram 650. Figure 6 illustrates how a CAD system in accordance with a fifth embodiment of the invention can be used to decide how a wide latitude digitally acquired image should be displayed on a display medium having a narrower latitude. One of the major problems in digital imaging is how to display all the information contained in the digitally acquired images. Typically, according to Feig et al in Volume 33 (1995) of Radiologic Clinics of North America, pages 1205-30, and other sources, the exposure range of the latitude (the ratio of the exposure at the highest signal region to that at the lowest signal region) of the digitally acquired image is of the order of 100 to over 1000, which is much broader than that of the display media. As a comparison, if a radiogram is to be displayed on a photographic film, the exposure range of the latitude (the ration of exposure at the highest signal region to that at the lowest signal region where the display gradient is significant) is of the order of 25 and the exposure range of the latitude of a TV monitor is less than 10. As illustrated in Figure 6, a CAD system 20 is used to guide into two different display media the display of a wide latimde digitally acquired image 800 formatted for example such that the log of its output signal (with an exposure range of over 1000) is encoded into 12 bits (4096 levels of gray). In this example, the CAD system decides how the digitally acquired wide latitude radiogram 800 shouid be printed on a photographic film 830 (having a display latitude of, fcr example, 25) and displayed on a high resolution TV or computer monitor 860 (having a display latitude of, for example. 10). As illustrated in Figure 6, this is done by centering the display latitude of the display medium (photographic film 830 or monitor 860) around the region of the CAD detected abnormality identified at 890 on the wide latitude digitally acquired image 800. That is, only the range of say the relative exposure 10 to 100. around the CAD detected abnormality 890, say around relative exposure 30, is provided at the optimum contrast gradient (say G=3.0) while other image content, above or below the exposure range of the CAD detected abnormality 890, are compressed in display latimde and are displayed with reduced contrast gradient on film 830 and/or monitor 860. Although the invention has been described in terms of preferred structures, methods and processes, it should be apparent to those skilled in the art that various alterations and modifications can be made without departing from the invention and that such modifications and alterations are intended to be considered to be within the spirit and scope of the invention as defined by the appended claims.

Claims: Claims: 1. A method comprising the steps of: converting a film mammogram to a digital mammogram; processing the digital mammogram by computer to identify suspected spiculated lesion and microcalcification cluster type abnormalities by type and location: producing an annotated digital map comprising symbols identifying the type and location of the abnormalities identified in the processing step; displaying the film mammogram on a light box for viewing; and concurrently displaying the annotated digital map on an electronic monitor for viewing adjacent to and substantially at the same viewing distance as the film mammogram. 2. A method as in claim 1 in which the step of producing the annotated digital map comprises producing a first map which contains the symbols and shows the area imaged on the film mammogram, and a second map which contains an emphasized version of one of said abnormalities and shows a smaller area. 3. A method as in claim 2 in which the producing step comprises magnifying the emphasized abnormality in the second map. 4. A method as in claim 2 in which the step of producing the annotated digital map further comprises producing a third map which contains another one of said abnormalities and also shows a smaller area. 5. A method as in claim 4 including the step of toggling said first map and second map for alternate display on said electronic monitor. 6. A method as in claim 4 including the step of concurrently displaying said first map and at least one of said second and third maps. . A method comprising the steps of: generating a digital mammogram; processing the digital mammogram by computer to identify suspected spiculated lesion and microcalcification cluster type abnormalities by type and location; producing an annotated digital map comprising symbols identifying the type and location of the abnormalities identified in the processing step; printing the digital mammogram and the annotated digital map on a laser film printer to produce a film mammogram with said annotated map at a marginal area thereof; and displaying the film mammogram, including said marginal area thereof, on a light box for viewing. 8. A method as in claim 7 in which the step of producing the annotated digital map comprises producing a first map which contains the symbols and shows in reduced format the entire area of the mammogram, and a second map which contains an emphasized version of one of said abnormalities and shows a smaller area. 9. A method as in claim 8 in which the producing step comprises magnifying the emphasized abnormality in the second map. 10. A method as in claim 8 in which the step of producing the annotated digital map further comprises producing a third map which contains another one of said abnormalities and also shows a smaller area. 11. A method as in claim 10 in which the step of printing comprises printing said first, second and third maps at the right margin of said film, outside the area of a typical breast image. 12. A method comprising the steps of: producing a low contrast, wide latitude film mammogram using a mammographic intensifying screen cassette; converting the low contrast, wide latitude film mammogram to a digital mammogram; processing the digital mammogram by computer to identify suspected spiculated lesion and microcalcification cluster type abnormalities by type and location, producing an annotated digital map comprising symbols identifying the type and location of the abnormalities identified in the processing step; printing the digital mammogram and the annotated digital map on a laser film pπnter to produce a viewing film mammogram with said annotated map at a marginal area thereof; and displaying the viewing film mammogram. including said marginal area thereof, on a light box for viewing. 13. A method as in claim 12 in which the step of producing the annotated digital map comprises producing a first map which contains the symbols and shows the area imaged on the low contrast, high latimde film mammogram, and a second map which contains one of said abnormalities and shows a smaller area. 14. A method as in claim 13 in which the producing step comprises emphasizing the abnormality in the second map. 15. A method as in claim 13 in which the step of producing the annotated digital map further comprises producing a third map which contains another one of said abnormalities and also shows a smaller area. 16. A method comprising the steps of: acquiring a wide latitude digital image having a relatively wide exposure range using a medical imaging modality; processing the digital image by computer to identify suspected abnormalities therein: finding a relatively narrow exposure range which includes an exposure range of at least one of the abnormalities: displa ing a narrow latitude version of said image conforming to said relatively narrow exposure range on a display device which is incapable of displaying said relatively wide exposure range. 17. A method as in claim 16 in which said displaying step comprises printing said narrow latimde image on photographic film for viewing. 18. A method as in claim 16 in which said displaying step comprises displaying said narrow latimde image on an electronic monitor for viewing. 19 A system comprising: a source of a film mammogram; a film reader/digitizer converting the film mammogram to a digital mammogram; a programmed computer processing the digital mammogram to identify suspected spiculated lesion and microcalcification cluster type abnormalities by type and location and to produce an annotated digital map comprising symbols identifying the type and location of the abnormalities; a light box displaying d e film mammogram for viewing; and an electronic momtor coupled to said programmed computer to concurrently display the annotated digital map for viewing adjacent to and substantially at the same viewing distance as the film mammogram. 20. A system as in claim 19 in which the annotated digital map comprises a first map which contains the symbols and shows the area imaged on the film mammogram, and a second map which contains one of said abnormalities and shows a smaller area. 21. A system as in claim 20 in which the annotated digital map further comprises a third map which contains a magnified version of another one of said abnormalities and also shows a smaller area. 22. A system as in claim 19 in which said source comprises a mammography unit. 23. A system comprising: a digital mammography unit generating a digital mammogram: a programmed computer processing the digital mammogram to identify suspected spiculated lesion and microcalcification cluster type abnormalities by type and location and to produce an annotated digital map comprising symbols identifying the type and location of the abnormalities; a printer coupled to the digital computer to print the digital mammogram and the annotated digital map so as to produce a film mammogram with said annotated map at a marginal area thereof; and a light box displaying the film mammogram. including said marginal area thereof, for viewing. 24. A system comprising: an intensifying screen cassette mammography unit producing a low contrast, wide latimde film mammogram; a film reader/digitizer converting the low contrast, wide latimde film mammogram to a digital mammogram; a computer processing the digital mammogram to identify suspected spiculated lesion and microcalcification cluster type abnormalities by type and location and to produce an annotated digital map comprising symbols identifying the type and location of the abnormalities; a printer coupled to said computer to print the digital mammogram and the annotated digital map to produce a viewing film mammogram with said annotated map at a marginal area thereof; and a light box displaying the viewing film mammogram, including said marginal area thereof, for viewing. 25. A system comprising: a medical imaging unit acquiring a wide latimde digital image having a relatively wide exposure range; a programmed computer processing the digital image to identify suspected abnormalities therein and to find a relatively narrow exposure range which includes an exposure range of at least one of the abnormalities; and a display device for displaying a narrow latimde version of said image conforming to said relatively narrow exposure range; wherein said display device is incapable of displaying said relatively wide exposure range. 26. A system as in claim 25 in which said display device comprises a film printer which prints said narrow latimde image on photographic film for viewing. 27. A system as in claim 25 in which said display device comprises an electronic monitor displaying said narrow latimde image for viewing.

Inventors: WANG SHIH-PING, WANG, SHIH-PING
Applicants: WANG SHIH PING, WANG, SHIH-PING
Application year: 1998
Main classification: G06K9
IPC codes: A61B6, G06T1, G06T7