PROCESS AND DEVICE FOR THE DETECTION AND THE QUANTITATIVE ANALYSIS OF VOLATILE SUBSTANCES

Abstract: A process and an installation for the detection and the quantitative analysis of volatile substances contained in a gaseous environment are described and claimed. These compounds have a low molecular weight and are in general ionisable. The process and installation work in the nanogram range. The gas that contains said compound(s) is circulated over a sensor comprising a thin layer of at least one calixarene, deposited on a support, at least one physical property thereof being able to undergo a change when the calixarene will have adsorbed said compound to be determined. This change of physical property constitutes a measure for the nature and the concentration of said volatile compound. Further, a sensor is disclosed where the morphological crystal organisation of the calixarene layer has been uniformed and equalised. This sensor is morphologically stable and yields fully reproducible results.

Description: Process and device for the detection and the quantitative analysis of volatile substances BACKGROUND OF THE INVENTION 1. Field of the invention The present invention belongs to the field of quantitative analysis, and it refers more particularly to a process and a device for the detection and the quantitative analysis in the nanogram region, of light compounds having generally but not exclusively an ionisable character and which are pre- sent in low concentrations in a gaseous environment, typically in ambient air. The present invention finds an interesting application in the detection and quantitative analysis of trace amounts of volatile light components, contained in ambient air and hav- ing generally an ionisable character. These compounds are generally known under the abbreviated denomination of VLC, namely volatile low molecular compounds, and some of them are organic compounds. The most important VLC are ammonia, lower aliphatic amines, hydrogen sulphide, mercaptans and disul- phides. Regarding the description of VLC and a process for purifying air containing same, see, for example, the document WO 97/31698 whose content is herewith incorporated by reference. Nowadays, it is strongly required to detect and quantita- tively analyse these compounds and still others in ambient air due to the evolution of environmental air pollution caused by the human society. The absolute amounts of these compounds and their concentration in ambient air are generally low but their detection is nevertheless necessary, aven in the range of some micrograms per cube meter. The detection of a low amount of a chemical substance and the evolution of its amount or its concentration in a gaseous medium such as ambient air as well, can be effected in principle by using very sensitive analysis instruments such as spectrometers or with the help of pick-up or sensor devices associated with data processing installations. The known analysis apparatuses and installations are generally complicated, bulky, expensive and difficult to be used. For these reasons, these installations can furthermore not be used in the great majority of cases for field analyses. 2. Description of the Prior Art Sensors for the detection and quantitative analysis of chemical compound molecules have already become known. These sensors are generally constituted by two distinct parts, namely a reactive portion which is sensitive to the molecules to be determined, called in the following "thin layer", and a transducer and carrier system, called in the following "support", for transforming the interaction between the reactive portion and the said molecules into an electric signal capa- ble of being processed further. The reactive portion may be constituted by a thin and immobile layer of a chemical substance, capable of capturing the molecules to be detected, be it by simple adsorption, by complexation, by a stoichiometric chemical reaction or by any other phenomenon capable of changing the physical and/or chemical properties of the thin layer. The transducer serves simultaneously as a carrier support for the thin layer and for creating an electric, optical, magnetic or other signal which is a differential signal with respect to the signal generated by the thin layer when it is uncharged or only partially charged by the molecules to be detected. The principles of such sensors are already known; see, for example, K.-D. Schierbaum et al . in Fresenius J. Anal. Chem 1994, 349:372-379. " SUMMARY OF THE INVENTION The known methods and devices for detecting and quantitatively analysing very low concentrations of volatile low molecular compounds suffer from a number of disadvantages. For example, the sensors are difficult to prepare (until now, high vacuum techniques must be used) ; they are not selective enough, their sensitivity and the reproducibility of the results are by far insufficient, etc. Known automatic devices for detecting, analysing and monitoring small amounts of low volatile molecular compounds are rather bulky and difficult to use. The first and major object of the present invention is to provide a process for the detection and the quantitative analysis, in the nanogram range, of volatile low molecular compounds having generally, but not exclusively, an ionisable character and which are present in low concentration in a gaseous environment, typically in the ambient atmosphere. Another object of the present invention is to provide an installation for implementing the process of the invention. These objects are fulfilled by the process and the installation according to the invention. The process is characterised in that the gaseous environment that contains the substance or substances to be detected, is contacted in a continuous stream with a sensor coated with a thin sensitive layer comprising at least one compound of the calixarene group, and the signal that is generated by the sensor is further processed. After this measurement process, the thin layer on the sensor may be regenerated to be ready for the next analysis. However, it is also contemplated in the invention to change or to replace the sensor. The installation of the invention contains at least a tubular closed circuit comprising a volumetric pump, at least one sensor for one or more volatile low molecular compounds, a feeding device for the gas to be analyses, and means for controlling, adjusting and data processing. The support of the sensor which is used may for example be a field effect transistor (FET), an optical fibre, or a piezoelectric device; the latter is already known per se and is presently preferred. However, these examples are not lim- iting; any support whatsoever that is capable of providing a signal in response of a changing physical or chemical condition can be used, for example sensors or pick-ups for temperature, force, electric frequency, magnetic conditions, humidity, pressure, capacity, etc. These sensors are coated with a thin layer of one or more calixarenes in order to render them sensitive to the volatile lightweight compounds. Examples for volatile low molecular compounds that can be determined and analysed in the present process and installation are ammonia, lower alkyl amines and lower alkenyl amines such as methylamine, dimethylamine, trimethylamine, mono- ethylamine, diethylamine, triethylamine, ethylendiamine, pro- penylamine and others; alcohols such as methanol and ethanol; ketones such as dimethylketone, diethylketone and methyl ethyl ketone; aldehydes such as formaldehyde and acetalde- hyde; hydrogen sulphide, hydrogen disulphide, methylmercaptan and other lower alkyl and lower alkenyl mercaptans, methane, ethane, propane, butane, etc.; chlorinated, brominated, fluorinated and iodinated alkanes and alkylenes; phosphine, stibine, hydrogen chloride, hydrogen bromide, hydrogen io- dide, hydrogen fluoride; arsine, hydrogen selenide; hydroxy- lamine, hydrazine; silane and higher silanes; tin hydride, etc. This list is not exhaustive. The attached drawing is to better explain particular or preferred embodiments of the present invention. BRIEF DESCRIPTION OF THE DRAWING In the drawing: FIG. 1 schematically shows an installation used for the evaluation of sensors, FIG. 2 shows a diagram of an analysis installation according to the invention, FIG. 3 shows as an example the adsorption curve of diethyl- amine on a sensor bearing a 25 nm thick layer of p- tert-butylcalix [4 ] arene according to Table I below, and FIG. 4 shows two X-ray diffraction spectra of p- ert-butyl- calix [4] arene having two different crystalline states corresponding to different accessible morphologies of the thin layer. DETAILED DESCRIPTION OF THE INVENTION The sensor used in the process and the installation of the invention is preferably a sensor bearing a thin layer of one or more calixarenes on a quartz crystal as a support. Such sensors are in principle already known, see the K.-D. Schierbaum et al . article cited above. According to this publication, a quartz oscillator, polished and equipped with gold electrodes, is coated with a thin layer of a calixarene in a thermal evaporation process under a very high vacuum. The quartz crystal which was used had an oscillation fre- quency of about 10 MHz. When the calixarene layer adsorbs perchloroethylene (C 2 CI 4 ) molecules or another organic substance, the above oscillation frequency undergoes a change that increases with the number of adsorbed perchloroethylene molecules, and this change can be measured and related to the amount of adsorbed molecules . The published experiments have been carried out in an evacuated vessel, and the pressure of organic compounds to be adsorbed is recorded to be 200 Pa (1.5 mm Hg) at a maximum. The publication neither describes nor suggests analyses at normal atmospheric conditions, adsorption from a gas stream, and does not mention the presence of volatile, low molecular organic or inorganic compounds to be adsorbed that have an ionisable character. According to the present invention, the following considerations have been made. When a quantitative analysis is to be made from a highly diluted system, such as only some nano- grams of a VLC contained in one litre of air, with the use of a sensor as described hereinafter, it will first be necessary to contact the sensor with a certain, predetermined and measured volume of that air. During this contact procedure, the above mentioned change of the oscillation frequency will be determined continuously or during short intervals. After a predetermined time duration, it will be necessary to prepare the sensor for the next analysis series, and to this end, it is required to desorb virtually the totality of the adsorbed molecules from the sensor. However, the applicants have shown in their previously cited patent application (WO 97/31698) that the volatile low molecular compounds, especially when they have an ionisable nature, are adsorbed by calixarenes in a strong and permanent manner since there occurs the formation of ionic bonds in the interior of the calixarene molecules. The one skilled in the art was therefore led to believe that the known calixarenic sensors which work in high vacuum environments could certainly not be used in a reversible adsorption and desorption as it is one of the basic findings of the present invention. Actually, the prior art did not disclose nor suggest or anticipate the behaviour of the calixarenic sensors in free air at normal temperature and pressure, containing extremely small amounts of VLC. Therefore, it has been found with great surprise that the above mentioned sensors not only work in a satisfactory man- ner in a gaseous environment of atmospheric pressure and room temperature but " also are capable of being reactivated or "recycled" by a current of purified gas. Of course, the speed of reactivation can be increased when a vacuum and/or elevated temperatures are applied; in this case also, it has surprisingly be found that a very high vacuum is not necessary for a rapid reactivation of the sensor but that the vacuum of a water jet glass filter pump supplying a vacuum in the range of 4,000 to 2,000 Pa (30 to 15 mm Hg) is fully sufficient for a virtually complete desorption when it is ap- plied for a time period of about 2 minutes only. These facts are extremely important for the practical application of the present process. One could perhaps believe that the calixarenes when they are used as a constituting element of a sensor will behave in a different manner, regarding the power of adsorption, compared with their use as a permanent capturing agent for VLC, due to the very different thickness of the adsorbing layers in these two cases. In fact, the thickness of the calixarene layer used in the present sensors varies in principle between 20 and 500 nm, preferably between 25 and 150 nm, which means about 38 to 225 molecular layers; some sensors can be prepared where the sensitive stratum is constituted by only 9 molecular layers. In contrast thereto, the thickness of the layers used for the permanent capturing of volatile low mo- lecular compounds is a tenth of a millimetre at a maximum. Such layers are thus at least a thousand times thicker that the previously mentioned ones. However, this is at present only an attempt of explaining this different behaviour of the calixarenes and could not be verified. The response of the sensor strongly depends on the thickness of the applied calixarene layer. According to an important development of the invention, the thickness of this layer is adapted to the expected concentration of the volatile low molecular compound to be determined. Furthermore, it has been found that the selection of a certain thickness results in an ad-sorption curve (adsorbed amount versus contact time) having a more or less inclined slope. FIG. 1 shows the schema of an installation for the detection, adsorption, measurement and desorption of volatile low molecular compound from a gaseous medium. This installation is used for the evaluation of the present sensors, and its principle can be used as a model for the construction of the installation according to the present invention. FIG. 1 shows a closed circuit 10 in which a gas is circu- lated, typically air at normal temperature and pressure. This circuit 10 is composed by three tubular sections 12, 14 and 16; a continuous gas stream is established and maintained by a pump 18, for example a peristaltic pump, whose delivery rate is known and adjustable. A sensor 20 is mounted within the tubular section 14, in this example a quartz crystal coated by a very thin layer of a calixarene as will be described later on. The sensor 20 is connected by an electric cable 22 to a station 26 for receiving, analysing and processing the signals coming from the sensor 20, for example a computer being equipped with appropriate software and connected to a printer and other peripherals if necessary (not shown) . An injection port 28, for example a silicone rubber membrane, is provided in the tubular section 12. A volatile low molecular compound may be injected into the system at this location. For carrying out a test, the station 26 is powered, and the pump 18 is started. When the gas flow is equilibrated, typically after 2 or 3 minutes, a measured amount of the com- pound to be detected is injected via the injection port 28. It is possible to make one or several different or identical injections. The sensor 20 will adsorb the volatile low molecular compound injected into the circuit 10, and an adsorp- tion curve is established by the system 28 and can then b evaluated. When this test installation according to FIG. 1 is to b used in practice, the circuit 10 is preferably furthe equipped for the reactivation of the sensor with a feed tub for the introduction of highly purified air or another pur gas, and the air which has been passed over the sensor is re moved from the circuit 10. After a short time, the senso will come back to its non-adsorption state (or to a threshol state near to zero adsorption) and be ready for the nex test. These additional elements and devices are not shown i FIG. 1. FIG. 2 shows the schema of an installation according t the invention for the detection and the quantitative analysi of one or more volatile low molecular compounds contained i a gaseous environment, typically air. This installation com prises a system of gas conduits 40 that form a closed cir cuit. This circuit contains successively a volumetric pum 42, a calibration gas metering and introducing device 44, calixarenic sensor 46, and a three-way cock 48. A valve 5 connects the circuit 40 to a vacuum pump V, and another valv 52 allows to open the circuit 40 to the free atmosphere A. The free, third connection of the three-way cock 48 i connected to a second three-way cock 54 whose two free out puts are connected, respectively, via a valve 58 to a sam pling port 56, and via a stop valve 60 to a rinsing and reac tivating gas reservoir 62. A filter device 64, optionally t be heated or to be cooled, may be inserted between the sam pling port 56 and the valve 58. The filter 64 and the sam pling port 56 may be replaced, when needed, by a removabl recipient (not shown) containing a gas sample that has bee taken at a distant location. All elements of the system 40 are connected, as it is shown in a schematical manner by the arrows C, to a device 66 for controlling, adjusting and for data processing that contains all the devices and elements which are required to run the installation, preferably in an automatic mode. Furthermore, FIG. 2 shows schematically a control field 70 for entering operation parameters and a display 68. The apparatus 66 is connected to a printer 72 or another recording device. It is possible to place the apparatus 66 very distant from the remainder of the installation or to provide remote control and/or remote display via an appropriate network (not shown) . The installation may be run in the following manner. The first step is a flushing and calibrating process. In order to rinse the system, it is flushed with the aid of a very pure and dry gas supplied from the reservoir 62; in this step, the cocks 54 and 48 are turned into position 2 as shown in FIG. 2. The valve 52 is slightly opened and also the valve 60. The pump 42 is turned on, and there will be a gas flow from reservoir 62 into the circuit 40; a circulating flow is established in this circuit whereas a fraction of the flushing and calibration gas is evacuated through the valve 52. Now follows the calibration. To this end, all valves are closed, and the three-way cock 48 is turned into position 1 (see FIG. 2) . After equilibration, about 2 to 3 minutes, a sample of a known volatile low molecular compound is injected into the circuit 40 through the injector device 44, the amount of the injected compound corresponding roughly to the amount of the same compound to be detected in an authentic gas sample; this approximate amount being estimated or being the result of another, former analysis. The frequency changes of the oscillating sensor 46 are followed on the display 68 and are recorded in the apparatus 66. When the calibration described above has been finished, the circuit is flushed once again in order to desorb the volatile low molecular compound adsorbed on the sensor. The valve 52 is opened, the cocks 48 and 54 are turned in position 2, and the valve 60 is opened until the lecture on the display 68 shows that the sensor 46 is in the reactivated state (at the threshold of zero adsorption) . The desorption may be accelerated when the valve 52 is closed and the valve 50 is opened and the cock 48 is turned in the 1 position. Finally, the section of the circuit between the valves 48 and 50 is flushed in turning the valve 48 for some time in the 3 position. The analysis may now be started. The valve 50 is closed, the three-way cock 48 is turned in the 2 position, and the cock 54 is turned in the 1 position. The valves 58 and 52 are opened, the pump 42 is started, and a metered volume of gas, coming from the surrounding atmosphere through the inlet port 56 and the filter 64 or, respectively, from a sampling device connected to the inlet port 56, is passed over the sensor 46 and leaves the circuit 40 through the valve 52. Normally, it is desired to determine the complete adsorption of the volatile low molecular compound in the circuit 40. In this case, the three-way valve 48 is turned into the 1 position, the valve 52 is closed, and the gas within the circuit 40 is circulated over the sensor 46 until a steady state is shown on the display 68. All changes in the oscillator fre- quency of the sensor 46 are shown on the display 68, recorded in the device 66 and compared with the calibration values. The device 66 is adapted to calculate the concentration of the volatile low molecular compound and to display the values directly, for example in ng/1 or μg/m 3 . In order to adapt the installation to variable requirements regarding the different nature and/or concentration of the volatile low molecular compound to be detected and quantitatively analysed, it is possible to provide a removable mounting of the sensor 46 so that it may easily and quic-kly be replaced by another one. It is even possible to mount several sensors, - preferably already calibrated, in a revolving device, thus allowing to engage immediately the desired sensor into the circuit. The following Tables show the results of adsorption assays. A quartz sensor has been used which was coated with layers of a calixarene having different thickness; the results have been obtained in the installation of FIG. 1. In the Tables, A signifies the active surface area of the sensor that is always the same. The volatile low molecular compound was diethylamine, injected in portions into air up to a final concentration of 720 ppm. Table I p- e -butylcalix [4] arene Coating 1 Initial res- ! Maximum res- JTime for reaching thickness, nm jponse, ng/A i ' ponse, ng/A I the maximum, sec 25 28 60 1000 50 15 35 1600 75 32 55 1600 100 8 17 650 125 4 10 1500 150 15 25 3500 Table II p- ert-butylcali [ 6] arene Table III p-tert-butylcalix [8] arene Coating |lnitial res- | Maximum res- J ime for reaching thickness, nm lponse, ng/A jponse, ng/A I the maximum, sec 25 8 20.5 50 8 25 75 12 21.5 100 20 48.5 1200 125 21 27.5 150 10 23 Table IV Calix [4] arene Coating i Initial res- j Maximum res- JTime for reaching thickness, nm iponse, ng/A Iponse, ng/A Ithe maximum, sec 25 8 35 50 40 120 75 15 83 100 3 34,5 4800 125 7 69 150 5 45 Table V Calix [8 ] arene Coating ! Initial res- j Maximum res- jTime for reaching thickness, nm jponse, ng/A iponse, ng/A Ithe maximum, sec 25 24 51 50 20 75 75 45 168 100 38 170 8000 125 40 228 150 20 78 FIG. 3 shows a diagram wherein the amount of diethylamine in ng per surface area A of the sensor (which has not been determined) is plotted on the ordinate and the analysis time duration in seconds on the abscissa. The diagram of FIG. 3 is based on the first assay compiled in the above Table I. The analysis was made at ambient temperature and pressure. The diethylamine was injected into the air circuit as 10 successive portions corresponding to 72.6 pp each. The first injection, made after 200 sec from the beginning, indicated by the arrow P, resulted in a rise to 28 ng/A, and the maximum of 60 ng/A was reached 1000 sec later on. A problem for which no solution whatsoever has until now be given in the prior art is how the sensitivity of the sensor could be adapted to the concentration of the volatile low molecular compound in the gaseous environment. Theoretically, one could think to vary the thickness of the thin layer of calixarene on the sensor. A thicker layer diminishes the sensitivity because the sensor will adsorb a greater amount of the calixarene before it is saturated. However, such a measure would result in an unacceptably long time duration of the analysis and/or a too small amount of volatile compound adsorbed compared with the first adsorption, see the above Table. On the other hand, another theoretic solution of the above depicted problem would be to use calixarenes having a greater number of annular members, such as cali [10] arene or even higher calixarenes. Although this possibility is part of the present invention, it should be taken into account that the volatile low molecular compound may be insuffi- ciently adsorbed, and the precision of the analyse is impaired due to the greater volume of the molecular cavities of these calixarenes. As a whole, the present invention suggests the use of any calixarene whatsoever, for example calix [4] arene, calix [6] arene, calix [8] arene, of dioxahomo- calixarenes and of resorcinolcalixarenes, these compounds being substituted or not. The sensors that are used in the process of the invention are prepared by applying a thin layer onto an appropriate support, preferably a quartz crystal, par example by the techniques of evaporation under vacuum, dip coating, spin coating, etc. At present, the evaporation method since it allows to obtain very thin and very pure layers. However, it has been found that it is extremely difficult or even impos- sible to obtain identical sensors: Either the thickness of the layers is different from one specimen to another, or the crystals in the thin layer have different polymorphological properties. Therefore, the sensitivity range of the sensor which has been prepared is not known beforehand. Still according to this invention, it has surprisingly been found that a heat treatment of the sensor just prepared changes the morphology of the calixarene crystals and results in a distinct and well defined form of the crystalline organisation. The only disadvantage of this heat treatment is a slight decrease in sensitivity but this fact should not be overestimated, the more as neither the response speed nor the precision and reproducibility of the adsorption are impaired. Furthermore, it has been found that the reversibility of the sensor is increased. This is to say that, during the above described reactivation by means of an flushing air stream or of a vacuum, the "free running" oscillation frequency of the sensor and thus its initial state are always returned to the same starting threshold. The reproducibility of the adsorption results is also found to be improved. This heat treatment is carried out by heating the sensor which has been obtained by the deposit of one or more calixarenes, to a temperature in the range of from about 80 °C to about 120 °C during 20 to 120 minutes under a molecular vacuum. FIG. 4 shows an X-ray diffraction spectrum of p-tert- butylcalix [4] arene on the surface of a sensor before and after the heat treatment (1 hour at 100 °C) . It can be seen that the initial deposit (curve A) has two peaks at 10 and 19 nm whereas the heat treated deposit (curve B) shows only one peak at 7 nm. The crystal morphology of the initial deposit has thus changed and yielded a unique and well defined new morphology. Other heat treatments, for example at other temperatures and/or during other time durations yield other changes of the crystal morphology and, thus, other sensitivi- ties . The invention is therefore further related to a sensor capable of being used in a device for detecting and quantitatively analysing volatile low molecular compounds contained in a gaseous environment, said sensor comprising a thin layer of at least one calixarene, resorcinolcalixarene or dihomoox- acalixarene, said calixarenes being substituted or not, deposited on a support whose physical properties undergo a reversible change when said volatile low molecular compounds are adsorbed, wherein the sensor has undergone a heat treat- ment in order to uniform and equalise the morphology of the thin layer. In these sensors as well in the others described herein, the thin calixarene layer is directly applied to the surface of the support but the invention also comprises sensors wherein said layer is deposited on a specially treated support surface, for example crystal surfaces coated with thin layers of a metal such as silver or gold, or of any other material necessary or desired to confer special or enhanced properties to the sensor. The new unique and well defined morphology of the thin calixarene coating has been confirmed by X-ray diffraction spectra made with glancing incidence. The calixarene crystals on the new, heat treated sensors form crystalline blo-cks of 10 to 15 μm long and 6 to 7 μm large, further containing still smaller crystals having a size of about 500 x 130 nm. The polymorphism as obtained plays a roll in the response of the sensors and modulate the interactions between the calixarenes, organised in thin layers, and the captured volatile molecules. This new property of the calixarene deposits can be created in all other cases where calixarenes in thin layers are used.

Claims: CLAIMS 1. Process for the detection and the quantitative analysis of volatile low molecular compounds, contained in low concentration in a gaseous medium, characterised in that a continuous stream of said gaseous medium is contacted with a sensor comprising a sensitive thin layer containing at least one calixarene on a support capable of generating a signal in response to the nature and/or the amount of said volatile low molecular compound adsorbed by said thin layer, and the generated signal is processed in order to determine the nature and/or the amount of said adsorbed compound. 2. Process according to claim 1, wherein said volatile low molecular compound contained in said gaseous medium is ionisable . 3. Process according to claim 1, wherein said gaseous medium is air. 4. Process according to claim 1, wherein said gaseous medium is contacted with said sensor at essentially normal temperature and atmospheric pressure. 5. Process according to claim 1, wherein a sensor is used comprising a thin layer of a calixarene on a quartz crystal support, and the changes of the oscillation frequency of the crystal in response to adsorbed volatile low molecular compound are measured and processed. 6. Process according to claim 1, wherein the thickness of said thin layer is comprised between 20 and 500 nm. 7. Process according to claim 6, wherein the thickness of said thin layer is comprised between 25 and 150 nm. 8. Process according to claim 1, wherein a sensor is used comprising a thin layer of a calix [4 ] arene, a calix[6]- arene, a calix [8 ] arene, a dioxahomocalixarene or a resorci- nolcalixarene, these compounds being unsubstituted or substi- tuted. 9. Process according to claim 1, wherein a calibration of the system used for the process is carried out prior to analysis, using a standard gas containing a known and predetermined amount of a volatile low molecular compound. 10. Process according to claim 9, wherein said calibration is carried out by the injection of a measured amount of a known volatile low molecular compound into said gaseous medium which is circulated over said sensor. 11. Process according to claim 1, wherein the sensor is regenerated after an analysis by passing a gas free from volatile low molecular compounds over the thin layer on said sensor, or said sensor is subjected to a vacuum. 12. Installation for the detection and the quantitative analysis of volatile low molecular compounds, contained in low concentration in a gaseous medium, characterised by a closed tubular circuit containing a volumetric pump, at least one sensor for the volatile low molecular compound (s), a feeding device for the gaseous medium to be analysed, and means for controlling, adjusting and for processing the data supplied by said sensor. 13. Installation according to claim 12, further comprising means for the metered supply of a calibration gas, connected to said circuit upstream said sensor. 14. Installation according to claim 12, further com- prising a reservoir for a reactivation gas. 15. Sensor for the use in an installation for detecting and quantitatively analysing at least one volatile low molecular compound contained in a gaseous medium, comprising a thin layer of at least one calixarene, a resorcinolcalixarene or a dioxahomocalixarene, these calixarenes being non substituted or substituted, on a support whose physical properties undergo a reversible change when said volatile low molecular compound is adsorbed on said calixarene, said sensor having been heat treated in order to uniform the crystal morphology of said calixarene in the thin layer. 16. Sensor according to claim 15, wherein said heat treatment is effected at a temperature in the range of from 80 to 120 °C during 20 to 120 minutes.

Inventors: CHOQUARD PHILIPPE, COLEMAN ANTHONY, GORELOFF PHILIPPE, LAMARTINE ROGER, MARCILLAC ARNOLD, MARTELIN YVON, CHOQUARD, PHILIPPE, COLEMAN, ANTHONY, GORELOFF, PHILIPPE, LAMARTINE, ROGER, MARCILLAC, ARNOLD, MARTELIN, YVON
Applicants: CHOQUARD PHILIPPE, COLEMAN ANTHONY, GORELOFF PHILIPPE, LAMARTINE ROGER, MARCILLAC ARNOLD, MARTELIN YVON, TRANSDIFFUSIA S A, CHOQUARD, PHILIPPE, COLEMAN, ANTHONY, GORELOFF, PHILIPPE, LAMARTINE, ROGER, MARCILLAC, ARNOLD, MARTELIN, YVON, TRANSDIFFUSIA S.A.
Application year: 1998
Main classification: G01N27
IPC codes: G01N27