SUBSTITUTED 6-ALKYLPHENANTHRIDINES

Abstract: Compounds of formula (I) in which R1, R2, R3, R31, R4, R5, R51, A and R6 have the meanings indicated in the description, are novel efficacious bronchial therapeutics.

Description: SUBSTITUTED 6-ALKYLPHENANTHRIDINES Field of application of the invention The invention relates to novel 6-alkylphenanthrιdιnes which are used in the pharmaceutical industry for the production of medicaments Known technical background German Patent Application DE 11 99 773 describes the preparation of 6-methyl-8,9-methylenedιoxy- 1 ,2,3,4,4a,5,6,1 ub-octahydrophenanthrιdιne, which should have analgesic, antiinflammatory and antipyretic properties In the Indian Journal of Chemistry 7, 1969, 674-677 the preparation of ethyl 1 ,2,3,4,4a,10b-hexahydrophenanthrιdιne-6-butyrate is described Description of the invention It has now been found that the novel 6-alkylphenanthπdιnes which are described below in greater detail have surprising and particularly advantageous properties The invention thus relates to compounds of the formula I in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, R2 is hydroxyi, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, or in which R1 and R2 together are a 1-2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, or in which R3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, R5 is hydrogen, R51 is hydrogen, or in which R5 and R51 together are an additional bond, A is 1-6C-alkylene or 5-7C-cycloalkylene, R6 is COOR61 or CON(R62)R63, where R61 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl and R62 and R63 independently of one another are hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, and the salts of these compounds. 1-4C-Alkyl represents a straight-chain or branched alkyl radical having 1 to 4 carbon atoms. Examples which may be mentioned are the butyl, isobutyl, sec-butyl, tert-butyl, propyl, isopropyl and, preferably, the ethyl and methyl radicals. 1-4C-Alkoxy represents radicals which, in addition to the oxygen atom, contain a straight-chain or branched alkyl radical having 1 to 4 carbon atoms. Examples which may be mentioned are the bu- toxy, isobutoxy, sec-butoxy, tert-butoxy, propoxy, isopropoxy and, preferably, the ethoxy and methoxy radicals. 3-7C-Cycloalkoxy represents cyclopropyloxy, cyclobutyloxy, cyclopentyloxy, cyclohexyloxy and cyclo- heptyloxy, of which cyclopropyloxy, cyclobutyloxy and cyclopentyloxy are preferred. 3-7C-Cycloalkylmethoxy represents cyclopropylmethoxy, cyclobutylmethoxy, cyclopentylmethoxy, cyclohexylmethoxy and cycloheptylmethoxy, of which cyclopropylmethoxy, cyclobutylmethoxy and cyclopentylmethoxy are preferred. Completely or predominantly fluorine-substituted 1-4C-alkoxy which may be mentioned are, for example, the 2,2,3,3,3-pentafluoropropoxy, the perfluoroethoxy, the 1 ,2,2-trifluoroethoxy, in particular the 1 ,1 ,2,2-tetrafluoroethoxy, the trifluoromethoxy, the 2,2,2-trifluoroethoxy and, preferably, the difluo- romethoxy radicals. "Predominantly" in this connection means that more than half of the hydrogen atoms are substituted by fluorine atoms. 1-2C-Alkylenedioxy represents, for example, the methylenedioxy (-0-CH 2 -0-) and the ethylenedioxy radicals (-0-CH 2 -CH O-). If R3 and R31 together have the meaning 1-4C-alkylene, the positions 1 and 4 in compounds of the formula I are linked to one another by a 1-4C-alkylene bridge, 1-4C-alkylene representing straight- chain or branched alkylene radicals having 1 to 4 carbon atoms. Examples which may be mentioned are the radicals methylene (-CH 2 -), ethylene (-CH 2 -CH 2 -), trimethylene (-CH 2 -CH 2 -CH ), 1 ,2-dimethyl- ethylene [-CH(CH 3 )-CH(CH 3 )-] and isopropylidene [-C(CH 3 ) 2 -]. if R5 and R51 together are an additional bond, then the carbon atoms in the positions 2 and 3 in compounds of the formula I are linked to one another via a double bond. 1-6C-Alkylene represents straight-chain or branched 1-6C-alkylene radicals, for example the methylene (-CH 2 -), ethylene (-CH 2 -CH 2 -), trimethylene (-CH 2 -CH 2 -CH 2 -), tetramethylene (-CH2-CH 2 -CH 2 -CH2-), 1 ,2-dimethyl-ethylene [-CH(CH 3 )-CH(CH 3 )-], 1 ,1 -dimethylethylene [-C(CH 3 ) 2 -CH 2 -], 2,2-dimethylethylene [-CH 2 -C(CH 3 ) 2 -], isopropylidene [-C(CH 3 ) 2 -], 1-methylethylene [-CH(CH 3 )-CH 2 -], pentamethylene (-CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -) and the hexamethylene radicals (-CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -). 5-7C-Cycioalkylene represents cycloalkylene radicals having 5 to 7 carbon atoms. Cyclohexylene radicals are preferred, where, for example, the 1 ,3- and the 1 ,4-cyclohexylene radicals may be mentioned. 1-7C-Alkyl represents straight-chain or branched alkyl radicals having 1 to 7 carbon atoms. Examples which may be mentioned are the heptyl, isoheptyl (5-methylhexyl), hexyl, isohexyl (4-methylpentyl), neohexyl (3,3-dimethylbutyl), pentyl, isopentyl (3-methylbutyl), neopentyl (2,2-dimethylpropyl), butyl, isobutyl, sec-butyl, tert-butyl, propyl, isopropyl, ethyl and methyl radicals. 3-7C-Cycloalkyl represents the cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl radicals. 3-7C-Cycloalkylmethyl represents a methyl radical which is substituted by one of the abovementioned 3-7C-cycloalkyl radicals. Examples which may be mentioned are the cyclopentylmethyl and the cyclo- hexylmethyl radicals. Suitable salts for compounds of the formula I - depending on substitution - are all acid addition salts or all salts with bases Particular mention may be made of the pharmacologically tolerable salts of the inorganic and organic acids and bases customarily used in pharmacy Those which are suitable are, on the one hand, water-soluble and water-insoluble acid addition salts with acids such as, for example, hydrochloric acid, hydrobromic acid, phosphoric acid, nitric acid, sulfuric acid, acetic acid, citric acid, D-gluconic acid, benzoic acid, 2-(4-hydroxybenzoyl)benzoιc acid, butyric acid, sulfosalicylic acid, maleic acid, lauπc acid, malic acid, fumaπc acid, succinic acid, oxalic acid, tartaric acid, embonic acid, stearic acid, toluenesuifonic acid, methanesulfonic acid or 3-hydroxy-2-naphthoιc acid, where the acids are employed in salt preparation - depending on whether it is a mono- or polybasic acid and depending on which salt is desired, in an equimolar quantitative ratio or one differing therefrom. On the other hand, salts with bases are also suitable Examples of salts with bases which may be mentioned are alkali metal (lithium, sodium, potassium) or calcium, aluminum, magnesium, titanium, ammonium, meglumme or guanidimum salts, where here too the bases are employed in salt preparation in an equimolar quantitative ratio or one differing therefrom Pharmacologically intolerable salts which may be obtained initially as process products, for example in the preparation of the compounds according to the invention on an industrial scale, are converted into pharmacologically tolerable salts by processes known to the person skilled in the art According to expert's knowledge the compounds of the invention as well as their salts may contain, e.g when isolated in crystalline form, varying amounts of solvents Included within the scope of the invention are therefore all solvates and in particular all hydrates of the compounds of formula I as well as all solvates and in particular all hydrates of the salts of the compounds of formula I Compounds of the formula I to be emphasized are those in which R1 is 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1 -2C-alkoxy, R2 is 1-4C-aikoxy, 3-7C-cycloalkoxy, 3-7C-cycloaikylmethoxy or completely or predominantly fluorine-substituted 1 -2C-alkoxy, R3 is hydrogen, R31 is hydrogen, or in which R3 and R31 together are a 1-2C-alkylene group, R4 is hydrogen or 1-4C-alkyl, R5 is hydrogen, R51 is hydrogen, or in which R5 and R51 together are an additional bond, A is 1-6C-alkylene or 5-7C-cycloalkylene, R6 is COOR61 or CON(R62)R63, where R61 is hydrogen, 1-7C-alkyi or 3-7C-cycloalkylmethyl and R62 and R63 independently of one another are hydrogen or 1-7C-alkyl, and the salts of these compounds. Compounds of the formula I particularly to be emphasized are those in which R1 is 1-4C-alkoxy, 3-7C-cycloalkoxy or completely or predominantly fluorine-substituted 1-2C- alkoxy, R2 is 1-4C-alkoxy, 3-7C-cycloalkoxy or completely or predominantly fluorine-substituted 1-2C- alkoxy, R3 is hydrogen, R31 is hydrogen, or in which R3 and R31 together are a 1-2C-alkylene group, R4 is hydrogen or 1-4C-alkyl, R5 is hydrogen, R51 is hydrogen, or in which R5 and R51 together are an additional bond, A is 1-6C-alkylene or 5-7C-cycloalkylene, R6 is COOR61 or CON(R62)R63, where R61 is hydrogen, 1 -4C-alkyl and R62 and R63 independently of one another are hydrogen or 1-4C-alkyl, and the salts of these compounds. Preferred compounds of the formula I are those in which R1 is 1-2C-alkoxy, R2 is 1-2C-alkoxy, R3 is hydrogen, R31 is hydrogen, R4 is hydrogen, R5 is hydrogen, R51 is hydrogen, A is cyclohexylene, R6 is COOR61 , where R61 is 1-4C-alkyl, and the salts of these compounds. The compounds of the formula I are chiral compounds having chiral centers in the positions 4a and 10b and, depending on the meaning of the substituents R3, R31 , R4, R5 and R51 , further chiral centers in the positions 1 , 2, 3 and 4. If A represents 5-7C-cycioalkylene, depending on the regiochemistry of the substitution, 2 further chiral centers also occur within the alkylene ring. Also, if A is 1-6C- alkyiene and the 1-6C-alkylene radical is branched, additional chiral centers can occur within the alkylene radical. Numbering: The invention therefore includes all conceivable pure diastereomers and pure enantiomers and their mixtures in any mixing ratio, including the racemates. The compounds of the formula I are preferred in which the hydrogen atoms in the positions 4a and 10b are cis to one another. Particularly preferred here are the pure cis diastereomers and the pure cis enantiomers and their mixtures in any mixing ratio and including the racemates. The enantiomers can be separated in a manner known per se (for example by preparation and separation of appropriate diastereoisomeric compounds). Preferably, a separation of enantiomers takes place at the stage of the starting compounds of the formula III for example via salt formation of the racemic compounds of the formula III with optically active car- boxylic acids. Alternatively, enantiomerically pure starting compounds of the formula III can also be prepared via asymmetric syntheses. If in the compounds of the formula I A is 5-7C-cycloalkylene or a branched 1-6C-alkylene radical, the stereochemistry within the alkylene radical is determined by the stereochemistry of the starting alkylene compounds used for the synthesis. The invention further relates to a process for the preparation of the compounds of the formula I, in which R1 , R2, R3, R31 , R4, R5, R51 , A and R6 have the meanings indicated above, and their salts. The process comprises cyclocondensing compounds of the formula II in which R1 , R2, R3, R31 , R4, R5, R51 , A and R6 have the meanings indicated above, and, if desired, then converting the compounds of the formula I obtained into their salts, or, if desired, then converting salts of the compounds of the formula I obtained into the free compounds. If desired, compounds of the formula I obtained can be converted into further compounds of the formula I by derivatization. For example, the corresponding acids can be obtained from compounds of the formula I, in which R6 is an ester group, by acidic or alkaline hydrolysis, the corresponding amides can be prepared by reaction with amines of the formula HN(R62)R63 or alternatively corresponding esters can be prepared by transesterification of esters of the formula i or by esterification of acids of the formula I. The reactions are expediently carried out analogously to the methods known to the person skilled in the art. Cyclocondensation is carried out in a manner known per se to the person skilled in the art according to Bischler-Napieralski (e.g. as described in J. Chem. Soc, 1956, 4280-4282) in the presence of a suitable condensing agent, such as, for example, polyphosphoric acid, phosphorus pentachloride, phosphorus trichloride, phosphorus pentoxide, thionyl chloride or preferably phosphorus oxychloride, in a suitable inert solvent, e.g. in a chlorinated hydrocarbon such as chloroform, or in a cyclic hydrocarbon such as toluene or xylene, or another inert solvent such as acetonitrile, or without further solvent using an excess of condensing agent, preferably at elevated temperature, in particular at the boiling temperature of the solvent or condensing agent used. Compounds of the formula II, in which R1 , R2, R3, R31 , R4, R5, R51 , A and R6 have the meanings indicated above, are accessible from the corresponding compounds of the formula III, in which R1 , R2, R3, R31 , R4, R5 and R51 have the meanings indicated above, by reaction with compounds of the formula R6-A-CO-X, in which R6 and A have the meanings indicated above and X is a suitable leaving group, preferably a chlorine atom. For example, benzoylation is carried out as in the following examples according to the Einhorn process, the Schotten-Baumann variant or as described in J. Chem. Soc. (C), 1971 , 1805-1808. Compounds of the formula R6-A-CO-X and compounds of the formula III are either known or can be prepared in a known manner. The compounds of the formula III can be prepared, for example, from compounds of the formula IV in which R1 , R2, R3, R31 , R4, R5 and R51 have the meanings mentioned above, by reduction of the nitro group. Reduction is carried out in a manner known to the person skilled in the art, for example as described in J. Org. Chem. 1962, 27, 4426 or as described in the following examples. Preferably, reduction is carried out by catalytic hydrogenation, e.g. in the presence of Raney nickel, in a lower alcohol such as methanol or ethanol at room temperature and under normal or elevated pressure. If desired, a catalytic amount of an acid, such as, for example, hydrochloric acid, can be added to the solvent. The compounds of the formula III, in which R1 , R2, R3, R31 and R4 have the meanings indicated above and R5 and R51 together are an additional bond, can be prepared from the corresponding compounds of the formula I by selective reduction of the nitro group in a manner known to the person skilled in the art, for example in the presence of Raney nickel in a lower alcohol as a solvent using hydrazine hydrate as a hydrogen donor. The compounds of the formula IV, in which R1 , R2, R3, R31 and R4 have the meanings indicated above and R5 and R51 are hydrogen, are either known or can be prepared from corresponding compounds of the formula IV, in which R5 and R51 together are an additional bond. The reaction can be carried out in a manner known to the person skilled in the art, preferably by hydrogenation in the presence of a catalyst, such as, for example, palladium on activated carbon, e.g. as described in J. Chem. Soc. (C), 1971 , 1805-1808. The compounds of the formula IV, in which R5 and R51 together are an additional bond, are either known or can be obtained by reaction of compounds of the formula V in which R1 and R2 have the abovementioned meanings, with compounds of the formula VI R3-CH=C(R4)-C(R4)=CH-R31 (VI) in which R3, R31 and R4 have the abovementioned meanings. Cycloaddition is carried out here in a manner known to the person skilled in the art according to Diels- Alder, e.g. as described in J. Amer. Chem. Soc. 1957, 79, 6559 or in J. Org. Chem. 1952, 17, 581 or as described in the following examples. Compounds of the formula IV obtained in the cycloaddition, in which the phenyl ring and the nitro group are trans to one another, can be converted into the corresponding cis compounds in a manner known to the person skilled in the art, e.g. as described in J. Amer. Chem. Soc. 1957, 79, 6559 or as described in the following examples. The compounds of the formulae V and VI are either known or can be prepared in a known manner. The compounds of the formula V can be prepared, for example, from corresponding compounds of the formula VII in a manner known to the person skilled in the art, as described, for example, in J. Chem. Soc. 1951 , 2524 or in J. Org. Chem. 1944, 9, 170 or as described in the following examples. The compounds of the formula VII in which R1 and R2 have the meanings indicated above, are either known or can be prepared in a manner known to the person skilled in the art, as described, for example, in Ber Dtsch Chem Ges 1925, 58, 203 The isolation and purification of the substances according to the invention is carried out in a manner known per se, for example by distilling off the solvent in vacuo and recrystallizing the resulting residue from a suitable solvent or subjecting it to one of the customary purification methods, such as, for example column chromatography on suitable support material Salts are obtained by dissolving the free compound in a suitable solvent, e g in a chlorinated hydrocarbon, such as methylene chloride or chloroform, or a low molecular weight aliphatic alcohol (etha- nol, isopropanol), which contains the desired acid or base or to which the desired acid or base is then added The salts are obtained by filtering, reprecipitation precipitation with a nonsolvent for the addition salt or by evaporation of the solvent Salts obtained can be converted by alkalization or by acidification into the free compounds which in turn can be converted into salts In this manner, pharmacologically intolerable salts can be converted into pharmacologically tolerable salts The following examples serve to explain the invention in greater detail without restricting it Likewise, further compounds of the formula I whose preparation is not described explicitly can be prepared in an analogous manner or in a manner familiar to the person skilled in the art using customary process techniques In the examples, m p stands for melting point h for hour(s), RT for room temperature, EF for empirical formula, MW for molecular weight, calc for calculated fnd for found The compounds and their salts mentioned in the examples are a preferred subject of the invention Examples Final products 1. (+/-)-cis-(4a.10b)-9-Ethoxy-8-methoxy-6-(trans-4-ethoxycarbonylcvclohexyl)- 1 ,2, 3,4,4a, 10b-hexahvdrophenanthridine 3.0 g of methyl (+/-)-trans-4-[cis-(1 ,2)-2-(3-ethoxy-4-methoxyphenyl)cyclohexyl-1-carbamoyl]cyclo- hexane-1-carboxylate (compound A1) are dissolved in 100 ml of acetonitrile and 3.0 ml of phosphorus oxychloride and stirred overnight at 80°C. The reaction mixture is treated with 60 ml of ethyl acetate and extracted with sodium hydrogencarbonate solution. The organic phase is dried using sodium sul- fate and concentrated. 2.0 g of the title compound are obtained as a solidifying oil. EF: C 2 H 33 N0 4 ; MW 399.53 Elemental analysis: calc: C 72.15 H 8.33 N 3.51 fnd: C 72.07 H 8.22 N 3.42 Starting compounds A1. Methyl (+/-)-trans-4-r/cis-(1 ,2)-2-(3-ethoxy-4-methoxyphenyl)cvclohexyl-1 -carbamovπcv- clohexane-1-carboxylate 3.0 g of (+/-)-cis-2-ethoxy-1-methoxy-4-(2-aminocyclohexyl)benzene (compound B1) are dissolved in 50 ml of methylene chloride and 10 ml of triethylamine. A solution of 2.95 g of methyl trans-4- chlorocarbonyicyclohexanecarboxylate is added dropwise at RT and the mixture is extracted after stirring overnight with 100 ml each of water, 2 N hydrochloric acid, saturated sodium hydrogencarbonate solution and water again. The organic phase is dried using sodium sulfate and concentrated. The residue is extracted by stirring with ethyl acetate/petroleum ether in the ratio 7/3, filtered off with suction and dried. 3.8 g of the title compound of m.p. 147-148°C are obtained. B1. (+/-)-cis-2-Ethoxy-1-methoxy-4-(2-aminocvclo-hexyl)benzene 40.0 g of (+/-)-cis-2-ethoxy-1-methoxy-4-(2-nitrocyclohex-4-enyl)benzene (compound C1) are dissolved in 1000 ml of ethanol and 500 ml of tetrahydrofuran, treated with 10 g of Raney nickel and hy- drogenated at a hydrogen pressure of 100 bar for 4 days in an autoclave. After filtration and removal of the solvent in vacuo, 35.9 g of the title compound are obtained as a solidifying oil. C1. (+/-)-cis-2-Ethoxy-1 -methoxy-4-(2-nιtrocyclohex-4-enyl)benzene 89 25 g of (+/-)-trans-2-ethoxy-1 -methoxy-4-(2-nιtrocyclohex-4-enyl)benzene (compound D1) and 37 g of potassium hydroxide are dissolved in 500 ml of absolute ethanol A solution of 23 5 ml of cone sulfuric acid in 120 ml of absolute ethanol is then added dropwise such that the internal temperature does not exceed -2°C After stirring for 1 h, the mixture is added to 4 I of ice water, and the precipitate is filtered off with suction, washed with water and dried M p 66-67°C D1. (+/-)-trans-2-Ethoxy-1 -methoxy-4-(2-nιtrocyclohex-4-envπbenzene 110 g of 3-ethoxy-2-methoxy-ω-nιtrostyrene (compound E1) and 360 mg of hydroqumone are suspended in 360 ml of absolute toluene and treated at -70°C with 180 ml of liquid 1 ,3-butadιene The mixture is stirred at 160-180°C for 6 days in an autoclave and then cooled The product is extracted by stirring with ethanol filtered off with suction and dried M p 130-131 °C E1. 3-Ethoxy-2-methoxy-ω-nιtrostyrene 236 g of 3-ethoxy-2-methoxybenzaldehyde 101 g of ammonium acetate and 320 ml of nitromethane are heated to 100°C for 4 h in 655 ml of glacial acetic acid The solution is added to 5 I of ice water, and the precipitate is filtered off with suction, washed with water and dried M p 132-133°C Commercial utility The compounds according to the invention have useful pharmacological properties which make them industrially utilizable. As selective cyclic nucleotide phosphodiesterase (PDE) inhibitors (specifically of type 4), they are suitable on the one hand as bronchial therapeutics (for the treatment of airway obstructions on account of their dilating action but also on account of their respiratory rate- or respiratory drive-increasing action) and for the removal of erectile dysfunction on account of their vascular dilating action, but on the other hand especially for the treatment of disorders, in particular of an inflammatory nature, e.g. of the airways (asthma prophylaxis), of the skin, of the intestine, of the eyes, of the CNS and of the joints, which are mediated by mediators such as histamine, PAF (platelet-activating factor), arachidonic acid derivatives such as leukotrienes and prostaglandins, cytokines, interleukins, chemokines, alpha-, beta- and gamma-interferon, tumor necrosis factor (TNF) or oxygen free radicals and proteases. In this context, the compounds according to the invention are distinguished by a low toxicity, a good enteral absorption (high bioavailability), a large therapeutic breadth and the absence of significant side effects. On account of their PDE-inhibiting properties, the compounds according to the invention can be employed in human and veterinary medicine as therapeutics, where they can be used, for example, for the treatment and prophylaxis of the following illnesses: acute and chronic (in particular inflammatory and allergen-induced) airway disorders of varying origin (bronchitis, allergic bronchitis, bronchial asthma); dermatoses (especially of proliferative, inflammatory and allergic type) such as psoriasis (vulgaris), toxic and allergic contact eczema, atopic eczema, seborrhoeic eczema, Lichen simplex, sunburn, pruritus in the anogenital area, alopecia areata, hypertrophic scars, discoid lupus erythema- tosus, follicular and widespread pyodermias, endogenous and exogenous acne, acne rosacea and other proliferative, inflammatory and allergic skin disorders; disorders which are based on an excessive release of TNF and leukotrienes, for example disorders of the arthritis type (rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis and other arthritic conditions), disorders of the immune system (AIDS, multiple sclerosis), types of shock (septic shock, endotoxin shock, gram-negative sepsis, toxic shock syndrome and ARDS (adult respiratory distress syndrome)) and also generalized inflammations in the gastrointestinal region (Crohn ' s disease and ulcerative colitis); disorders which are based on allergic and/or chronic, immunological false reactions in the region of the upper airways (pharynx, nose) and the adjacent regions (paranasal sinuses, eyes), such as allergic rhinitis/sinusitis, chronic rhinitis/sinusitis, allergic conjunctivitis and also nasal polyps; but also disorders of the heart which can be treated by PDE inhibitors, such as cardiac insufficiency, or disorders which can be treated on account of the tissue-relaxant action of the PDE inhibitors, such as, for example, erectile dysfunction or colics of the kidneys and of the ureters in connection with kidney stones; and also illnesses of the central nervous system, such as depressions or arteriosclerotic dementia. The invention further relates to a method for the treatment of mammals, including humans, which are suffering from one of the abovementioned illnesses. The method is characterized in that a therapeuti- cally active and pharmacologically effective and tolerable amount of one or more of the compounds according to the invention is administered to the ill mammal. The invention further relates to the compounds according to the invention for use in the treatment and/or prophylaxis of illnesses, especially the illnesses mentioned. The invention also relates to the use of the compounds according to the invention for the production of medicaments which are employed for the treatment and/or prophylaxis of the illnesses mentioned. The invention furthermore relates to medicaments for the treatment and/or prophylaxis of the illnesses mentioned, which contain one or more of the compounds according to the invention. The medicaments are prepared by processes which are known per se and familiar to the person skilled in the art. As medicaments, the compounds according to the invention (= active compounds) are either employed as such, or preferably in combination with suitable pharmaceutical auxiliaries, e.g. in the form of tablets, coated tablets, capsules, suppositories, patches, emulsions, suspensions, gels or solutions, the active compound content advantageously being between 0.1 and 95%. The person skilled in the art is familiar with auxiliaries which are suitable for the desired pharmaceutical formulations on account of his expert knowledge. In addition to solvents, gel formers, ointment bases and other active compound excipients, for example antioxidants, dispersants, emulsifiers, preservatives, solubilizers or permeation promoters, can be used. For the treatment of disorders of the respiratory tract, the compounds according to the invention are preferably also administered by inhalation. To do this, these are either administered directly as a powder (preferably in micronized form) or by atomizing solutions or suspensions which contain them. With respect to the preparations and administration forms, reference is made, for example, to the details in European Patent 163 965. For the treatment of dermatoses, the compounds according to the invention are in particular administered in the form of those medicaments which are suitable for topical application. For the production of the medicaments, the compounds according to the invention (= active compounds) are preferably mixed with suitable pharmaceutical auxiliaries and further processed to give suitable pharmaceutical formulations. Suitable pharmaceutical formulations are, for example, powders, emulsions, suspensions, sprays, oils, ointments, fatty ointments, creams, pastes, gels or solutions. The medicaments according to the invention are prepared by processes known per se. The dosage of the active compounds is carried out in the order of magnitude customary for PDE inhibitors. Topical application forms (such as ointments) for the treatment of dermatoses thus contain the active com- pounds in a concentration of, for example, 0.1-99%. The dose for administration by inhalation is cus- tomarly between 0.1 and 3 mg per day. The customary dose in the case of systemic therapy (p.o. or i.v.) is between 0.03 and 3 mg/kg per day. Bioloqical investigations In the investigation of PDE 4 inhibition on the cellular plane, the activation of inflammatory cells is ascribed particular importance. An example is FMLP (N-formyl-methionyl-leucyl-phenylalanine)- induced superoxide production of neutrophilic granulocytes, which can be measured as luminol- amplified chemiluminescence. (Mc Phail LC, Strum SL, Leone PA and Sozzani S, The neutrophil respiratory burst mechanism. In "Immunology Series" 57: 47-76, 1992; ed. Coffey RG (Marcel Decker, inc., New York-Basel-Hong Kong)). Substances which inhibit chemiluminescence and cytokine secretion and the secretion of proinflam- matory mediators on inflammatory cells, in particular neutrophilic and eosinophiiic granulocytes, T- lymphocytes, monocytes and macrophages are those which inhibit PDE 4. This isoenzyme of the phosphodiesterase families is particularly represented in granulocytes. Its inhibition leads to an increase in the intracellular cyclic AMP concentration and thus to the inhibition of cellular activation. PDE 4 inhibition by the substances according to the invention is thus a central indicator for the suppression of inflammatory processes. (Giembycz MA, Could isoenzyme-selective phosphodiesterase inhibitors render bronchodilatory therapy redundant in the treatment of bronchial asthma?. Biochem Pharmacol 43: 2041-2051 , 1992; Torphy TJ et al., Phosphodiesterase inhibitors: new opportunities for treatment of asthma. Thorax 46: 512-523, 1991 ; Schudt C et al., Zardaverine: a cyclic AMP PDE 3/4 inhibitor. In "New Drugs for Asthma Therapy", 379-402, Birkhauser Verlag Basel 1991 ; Schudt C et al., Influence of selective phosphodiesterase inhibitors on human neutrophil functions and levels of cAMP and Ca; Naunyn-Schmiedebergs Arch Pharmacol 344; 682-690, 1991 ; Tenor H and Schudt C, Analysis of PDE isoenzyme profiles in cells and tissues by pharmacological methods. In "Phophodiesterase Inhibitors", 21-40, "The Handbook of Immunopharmacology", Academic Press, 1996; Hatzelmann A et al., Enzymatic and functional aspects of dual-selective PDE3/4-lnhibitors. In "Phosphodiesterase Inhibitors", 147-160, "The Handbook of Immunopharmacology", Academic Press, 1996. I. Inhibition of PDE 4 activity Methodology The activity test was carried out by the method of Bauer and Schwabe, which was adapted to micro- titer plates (Naunyn-Schmiedeberg's Arch. Pharmacol. 1980, 3_U, 193-198). In this connection, the PDE reaction is carried out in the first step, in a second step, the resultant 5'-nucleotide is cleaved to give the uncharged nucleoside by a 5'-nucleotidase of the snake venom from Crotalus atrox. In the third step, the nucleoside is separated from the remaining charged substrate on ion exchange columns. The columns are eluted with 2 ml of 30 mM ammonium formate (pH 6.0) directly into minivials to which 2 ml of scintillation fluid is additionally added for counting. The inhibitory values determined for the compounds according to the invention [inhibitory concentration as -log IC 50 (mol/l)] follow from Table A below, in which the numbers of the compounds correspond to the numbers of the examples. Table A Inhibition of PDE 4 activity

Claims: Patent claims A compound of the formula I in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy, or in which R1 and R2 together are a 1-2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, or in which R3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, R5 is hydrogen, R51 is hydrogen, or in which R5 and R51 together are an additional bond, A is 1-6C-alkylene or 5-7C-cycloalkylene, R6 is COOR61 or CON(R62)R63, where R61 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl and R62 and R63 independently of one another are hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, or the salts of this compound. 2. A compound of the formula I as claimed in claim 1 , in which R1 is 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1 -2C-alkoxy , R2 is 1-4C-alkoxy, 3-7C-cycioalkoxy, 3-7C-cycloalky!methoxy or completely or predominantly fluorine-substituted 1-2C-alkoxy, R3 is hydrogen, R31 is hydrogen, or in which R3 and R31 together are a 1-2C-alkylene group, R4 is hydrogen or 1-4C-alkyl, R5 is hydrogen, R51 is hydrogen, or in which R5 and R51 together are an additional bond, A is 1-6C-alkylene or 5-7C-cycloalkylene, R6 is COOR61 or CON(R62)R63, where R61 is hydrogen, 1-7C-alkyl or 3-7C-cycloalkylmethyl and R62 and R63 independently of one another are hydrogen or 1-7C-alkyl, or the salts of this compound. 3. A compound of the formula I as claimed in claim 1 , in which R1 is 1-4C-alkoxy, 3-7C-cycloalkoxy or completely or predominantly fluorine-substituted 1-2C- alkoxy, R2 is 1-4C-alkoxy, 3-7C-cycloalkoxy or completely or predominantly fluorine-substituted 1-2C- alkoxy, R3 is hydrogen, R31 is hydrogen, or in which R3 and R31 together are a 1-2C-alkylene group, R4 is hydrogen or 1-4C-alkyl, R5 is hydrogen, R51 is hydrogen, or in which R5 and R51 together are an additional bond, A is 1-6C-aIkylene or 5-7C-cycloalkylene, R6 is COOR61 or CON(R62)R63, where R61 is hydrogen, 1-4C-alkyl and R62 and R63 independently of one another are hydrogen or 1-4C-alkyl, or the salts of this compound. 4. A compound of the formula I as claimed in claim 1 , in which R1 is 1-2C-alkoxy, R2 is 1-2C-alkoxy, R3 is hydrogen, R31 is hydrogen, R4 is hydrogen, R5 is hydrogen, R51 is hydrogen, A is cyclohexylene, R6 is COOR61 , where R61 is 1-4C-alkyl, or the salts of this compound. 5. A compound of the formula I as claimed in claim 1 for use in the treatment of diseases. 6. A medicament comprising at least one compound of the formula I as claimed in claim 1 together with pharmaceutical auxiliaries and/or excipients. 7. The use of compounds of the formula I as claimed in claim 1 for the production of medicaments for the treatment of airway disorders.

Inventors: AMSCHLER HERMANN, BAER THOMAS, BEUME ROLF, BOSS HILDEGARD, FLOCKERZI DIETER, GUTTERER BEATE, HAEFNER DIETRICH, HATZELMANN ARMIN, KLEY HANS-PETER, MARTIN THOMAS, SCHUDT CHRISTIAN, ULRICH WOLF-RUEDIGER, AMSCHLER, HERMANN, BAER, THOMAS, BEUME, ROLF, BOSS, HILDEGARD, FLOCKERZI, DIETER, GUTTERER, BEATE, HAEFNER, DIETRICH, HATZELMANN, ARMIN, KLEY, HANS-PETER, MARTIN, THOMAS, SCHUDT, CHRISTIAN, ULRICH, WOLF-RUEDIGER
Applicants: BYK GULDEN LOMBERG CHEM FAB, GUTTERER BEATE, BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH, GUTTERER, BEATE
Application year: 1998
Main classification: C07D221
IPC codes: A61K31, A61P1, A61P9, A61P11, A61P13, A61P17, A61P19, A61P25, A61P29, A61P37, A61P43, C07D221, C07D491