CENTIPEDA PLANT EXTRACT

Abstract: The present invention relates generally to a novel plant composition. More particularly, the present invention provides a composition comprising an extract from the plant Centipeda Cunninghamii or related Centipeda species and an orally or topically acceptable carrier. The Centipeda plant extracts of the present invention are useful in a range of cosmetic, therapeutic and prophylactic applications.

Description: CENTIPEDA PLANT EXTRACT The present invention relates generally to a novel plant composition. More particularly, the present invention provides a composition comprising an extract from the plant Centipeda cunninghamii or related Centipeda species and an orally or topically acceptable carrier. The Centipeda plant extracts of the present invention are useful in a range of cosmetic, therapeutic and prophylactic applications. Throughout this specification unless the context requires otherwise, the word "comprise", or variations such as "comprises" or "comprising", will be understood to imply the inclusion of a stated integer or group of integers but not the exclusion of any other integer or group of integers. The plant kingdom has provided an abundant source of many compounds for use in a wide range of cosmetic, therapeutic and prophylactic applications. Indeed, throughout history plants or parts thereof have been used in many ways including the making of oral, topical, and iηjectable preparations. Centipeda cunninghamii and related plant species have been used by the Aboriginal people of Australia for many generations in the treatment and prevention of many ailments. C cunninghamii is commonly know as Gukwonderuk, koona puturku, sneezeweed, old man weed or scent wood. C. cunninghamii is known to grow primarily in the lower temperate regions of south-eastern Australia. It is commonly found along stream banks and in the back wash of rivers or streams where the water is stagnant. Traditionally C. cunninghamii has been used by the Aboriginal people as a tea, which has either been taken orally or used directly on the skin. Although C. cunninghamii has been used by the Aboriginal people there is little known about this plant and the active component(s) responsible for its various properties. Investigations by the present inventors have provided a method for preparing an extract from C. cunninghamii and related Centipeda species in order to effectively obtain active compounds. In work leading up to the present invention, the inventors sought to develop compositions comprising an extract from plants in the genus Centipeda useful in the effective treatment and prophylaxis of many types of medical problems as well as for cosmetic applications. The inventors have now surprisingly discovered that when an aqueous alcoholic extract of C. cunninghamii or a related Centipeda species is combined with a variety of suitable carriers it is useful for topical or oral treatment and prophylaxis of many types of medical conditions as well as for cosmetic applications. Accordingly, one aspect of the present invention contemplates a composition for the treatment and prophylaxis of medical conditions and/or for use in cosmetic treatments of a human or other animal, comprising an aqueous alcoholic extract from a plant of the genus Centipeda, combined with an acceptable carrier and/or diluent. The compositions of the present invention have a wide range of utilities in the topical treatment of, for example, acne and pimples, herpes, bed sores, skin irritations, cuts, psoriasis, skin sun damage, eczema and dermatitis. In addition, the compositions are useful in the oral treatment of, for example, nasal irritations and are effective as diuretics. The compositions of the present invention appear to have several properties, such as being anti- allergy, anti-irritant, anti-bacterial and anti-inflammatory. In addition, they are effective as skin proliferators in, for examples, cosmetic applications and skin disease. The present invention is exemplified herein with respect to humans. However, this is done with the understanding that the present invention extends to all animal including humans, laboratory test animals (e.g. primates, mice, rabbits, hamsters, guinea pigs), livestock animals (e.g. sheep, goats, horses, pigs, cows, donkeys), companion animals (e.g. dogs, cats), captive wild animals (e.g. foxes, kangaroos, dingoes), poultry birds (e.g. chickens, geese, ducks), game birds (e.g. emus, ostriches) and fish and reptiles (eg. fish, lizards, snakes, turtles). The aqueous alcoholic extract contemplated by the present invention is generally prepared from part (i.e. leaves, flowers, seeds, stems, roots) or all of the Centipeda cunninghamii plant or other related species of Centipeda. The aqueous alcoholic extract can be prepared by utilizing an adequate extraction method (eg. by maceration, percolation, infusion, decoction) consisting of, but not limited to, various alcoholic solvents such as aqueous ethanolic solvents. A preferred extract is obtained by extraction of dried plant material with aqueous ethanol, comprising 30% ethanol/70% water or a range of strengths. Topical compositions of the present invention comprise an aqueous alcoholic extract together with a suitable carrier for topical administration. For example, the extract may be combined with one or more of the following carriers: emulsifiers (eg. beeswax, stearic acid), skin protectants (eg. dimethicone), skin conditioners (eg. olive oil, avocado oil, cetyl stearyl alcohol), humectants (eg. glycerin), preservatives (eg. methyl hydroxybenzoate), solvents (eg. water), herbal actives (eg. aloe vera), essential oils (eg. sandalwood oil, lavender oil), suspension agents (eg. fractionated coconut oil), anionic emulsifying agents (eg. cocoamidopropyl betaine), astringents (eg. zinc phenosulfonate), antiseptics (eg. zinc chloride), antibacterials (eg. triclosan), healing agents (eg. allantoin), germicides (eg. tea tree oil), anti-inflammatories (eg. pineapple extract), skin fresheners (eg. lemon extract), wetting agents (eg. cocoamidopropyl betaine), antioxidants (eg. lecithin), skin lubricants (eg. jojoba oil), emollients (eg. honey), absorbing agents (eg. purified talc), preservatives (eg. methyl hydroxybenzoate) and/or skin/hair conditioners (eg. olive oil). Oral compositions of the present invention comprise an aqueous alcoholic extract together with a suitable carrier for oral administration. For example, the extract may be combined with one or more of the following carriers: abrasives (eg. calcium carbonate), solvents (eg. water), humectants (eg. glycerine), detergents (eg. sodium lauryl sulphate), binders (eg. cellulose gum), herbal actives (eg. aloe vera ), essential oils (eg. eucalyptus oil, peppermint oil), deodorizing agents (eg. chlorophyll) and/or a suspension agents (eg. hydrogenated castor oil). Another aspect of the present invention provides a method of treatment or prophylaxis of medical conditions and/or a method of cosmetic treatment of a human or other animal, comprising administration of a composition comprising an aqueous alcoholic extract from a plant of the genus Centipeda, combined with an acceptable carrier and/or diluent. Medical conditions contemplated by the present invention comprise but are not limited to rashes and allergic reactions, inflammations, bacterial infections and gastrointestinal problems generally. Cosmetic treatments contemplated by the present invention comprise but are not limited to skin and/or hair treatments and/or oral treatments, such as, deodorants, facial scrubs, shaving creams and gels, eye/face creams and gels, make-up removers, toners, cleansers, shampoos, conditioners and breath fresheners. A variety of administration routines are available. The particular mode selected will depend, of course, upon the particular condition being treated and the dosage required for therapeutic, prophylactic or cosmetic efficacy. The methods of this invention, generally speaking, may be practised using any mode of administration that is topically or orally acceptable, meaning any mode that produces effective levels of the active component of the invention without causing clinically unacceptable adverse effects. Such modes of administration include oral (eg. tablets, mouth washes, mouth gels, mouth lotions, gargle solutions, toothpastes, emmenagogues) and topical (eg. creams, paints, sprays, pastes, liniments, lotions, ointments). The compositions of this invention may conveniently be presented in unit dosage form and may be prepared by any of the methods well known in the art of pharmacy and cosmetics. Such methods include the step of bringing the active component into association with a carrier which constitutes one or more accessory ingredients. The formulation of such therapeutic, prophylactic and cosmetic compositions is well known to persons skilled in these fields. Suitable pharmaceutically acceptable carriers and/or diluents include any and all conventional solvents, dispersion media, fillers, solid carriers, aqueous solutions, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, and the like. The use of such media and agents for pharmaceutically active substances is well known in the art, and it is described, by way of example in Remington's Pharmaceutical Sciences, 18th Edition, Mack Publishing Company, Pennsylvania, USA. Except insofar as any conventional media or agent is incompatible with the active component, use thereof in the compositions of the present invention is contemplated. Supplementary active ingredients can also be incorporated into the compositions. Accordingly, a further aspect of the present invention contemplates a method of oral treatment or prophylaxis of medical conditions of a human or other animal, comprising oral administration of an aqueous alcoholic extract from a plant of the genus Centipeda, combined with an orally suitable carrier. Compositions of the present invention suitable for oral administration may be presented as discrete units such as ingestible tablets, buccal tablets, capsules, lozenges, cachets, wafers and the like, each containing a predetermined amount of the active component, in liposomes or as a suspension in an aqueous liquid or non-liquid such as a syrup, an elixir, or an emulsion. The oral treatment contemplated by the present invention includes, for example, the swallowing or ingestion of tablets, capsules, lozenges, cachets, wafers, solutions, syrups, elixirs or emulsions. In addition, oral treatment includes compositions applied within the mouth cavity for a local effect, for example, as mouth lotions, mouth gels or gargle solutions. Accordingly, a further aspect of the present invention contemplates a method of topical treatment or prophylaxis of medical conditions or a topical cosmetic treatment of a human or other animal, comprising topical administration of an aqueous alcoholic extract from a plant of the genus Centipeda, combined with an topically suitable carrier. Compositions of the present invention suitable for topical administration may be presented as a liquid or semi-liquid preparation intended for application to the skin, hair, nails or nasal passages, for example, as follows: a cream a homogeneous viscous or sem-solid emulsion, a gel (eg. semi-solid preparation), a liniment (ie. a liquid preparation), a lotion (ie. a semi-liquid preparation), an ointment (ie. a semi-solid preparation), a paint (ie. a liquid preparation that is brushed onto the skin), a paste (ie. a semi-solid preparation for external application), a solution (ie. a liquid preparation), a spray (ie. a liquid preparation dispersed with a spraying device), a stick (ie. a solid preparation) or a suspension (ie. a liquid preparation). Throughout this specification unless the context requires otherwise, the terms "aqueous alcoholic extract", "Centipeda plant extract" and "plant extract" are intended to have the same meaning. Further features of the present invention are more fully described in the following Example(s). It is to be understood, however, that this detailed description is included solely for the purposes of exemplifying the present invention, and should not be understood in any way as a restriction on the broad description of the invention as set out above. Example 1 Procedure for preparation of the aqueous alcohol extract from C. cunninshamii PROCEDURES: Cold maceration process using aqueous/alcohol in a range of strengths i.e. 10% Ethanol:Water to 95% Ethanol.Water. SOLVENTS USED: Ethanol all types i.e. 100SG 95SG ETC Denatured ethanol all types i.e. F1-F2 etc Water all types, i.e. purified, distilled, potable, etc. PLANT PARTS USED: Whole plant, leaves, flowers, seeds, stems, roots. RATIO: Dried plant = 6-1 to 7-1 of fresh plant depending on dryness. TIME: Maceration time = 6 weeks for 30% Ethanol: Water, but can vary with different levels of solvent strengths PROTOCOL: 20-23.5kg of dried plant whole or chopped into small pieces are placed into a vessel i.e. stainless steel, poly etc. with a range of Ethanol: Water strengths ranging from 10% Ethanol:Water to 95% Ethanol: Water and left to macerate for a period of approximately 6 weeks, at the completion the material is pressed and the liquid is filtered. The recovered liquid can vary depending on Ethanol:Water strength. The following methods use the same plant parts of C. cunninghamii as stated in cold maceration process. PERCOLATING METHOD: Suitable solvents are used i.e. water, ethanol or a combination in a variety of strengths at a temperature to suit the solvents. INFUSION METHOD: Material is placed in a suitable container and covered with boiling water and allowed to cool then strained, pressed and filtered. It can be used as is or have a preservative added i.e. methyl/propyl hydroxybenzoate, ethanol etc. DECOCTION: Plant is placed into suitable container i.e. boiler which can have heat applied to it by different means i.e. gas, electricity, steam etc. The material is covered with water and heated to boiling point then left to cool, pressed and filtered and a suitable preservative is added, i.e. ethanol, methyl/propyl hydroxybenzoate. GREEN/FRESH PLANT EXTRACT OR TINCTURE: Fresh plant/material is placed into a suitable vessel and covered with a range of strengths of Ethanol: Water as used in cold maceration process. OIL INFUSION: Dried plant is placed into a suitable container and covered with oil either cold or heated. A range of oils can be used in singular or multi combination, oils can be grapeseed, olive sunflower, evening primrose etc. the mixture is left for 1-6 weeks depending on the heat and type of oil used. A mixture of oil and ethanol can also be used. The plant is drained and pressed at the completion of the process. ALCOHOL/ETHANOL EXTRACTION: The dried plant is placed in a suitable vessel/container and covered with ethanol or denatured ethanol. Allowed to steep for a period of 1-6 weeks. The material is then pressed and filtered. Example 2 BABY NAPPY CHANGE CREAM: Barrier Cream The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a barrier cream in particular as a baby nappy change cream. INGREDIENTS % FUNCTION BEESWAX 0.6 EMULSIFIER CETYL STEARYL ALCOHOL 7.5 SKIN CONDITIONER LANOLIN WAX 1.0 EMULSIFIER CETOMACROGOL 1000 1.6 EMULSIFIER DIMETHICONE 2.0 SKIN PROTECTANT OLIVE OIL 7.5 SKIN CONDITIONER GLYCERIN 5.0 HUMECTANT METHYL HYDROXYBENZOATE 0.3 PRESERVATIVE PURIFIED WATER 54.5 SOLVENT ALOE VERA 6.0 HERBAL ACTIVE WATTLE EXTRACT 1-1 2.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 6.0 HERBAL ACTIVE CHAMOMILE EXTRACT 1-1 1.0 HERBAL ACTIVE LAVENDEREXTRACT 1-1 2.2 HERBAL ACTIVE SANDALWOOD OIL 0.3 ESSENTIAL OIL LAVENDER OIL 0.6 ESSENTIAL OIL LAURYL ALCOHOL 0.5 EMULSIFIER FRACTIONATED COCONUT OIL 0.4 SUSPENSION AGENT CAJUPUT OIL 1.0 ESSENTIAL OIL TOTAL 100.0 Example 3 BABY SOOTHING SKIN CREAM The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a baby sooting skin cream. INGREDIENTS % FUNCTION CETYL STEARYL ALCOHOL 9.0 SKIN CONDITIONER CETOMACROGOL 1000 1.6 EMULSIFIER OLIVE OIL 7.5 SKIN CONDITIONER GLYCERIN 4.5 HUMECTANT METHYL HYDROXYBENZOATE 0.3 PRESERVATIVE PURIFIED WATER 53.1 SOLVENT ALOE VERA 7.2 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 8.0 HERBAL ACTIVE LAVENDEREXTRACT 1-1 1.6 HERBAL ACTIVE CALENDULAEXTRACT 1-1 2.0 HERBAL ACTIVE WATTLE EXTRACT 1-1 3.0 HERBAL ACTIVE LAURYL ALCOHOL 0.5 EMULSIFIER FRACTIONATED COCONUT OIL 0.4 SUSPENSION AGENT LEMON OIL 0.4 ESSENTIAL OIL LAVENDEROLL 0.2 ESSENTIAL OLL CAJUPUT OIL 0.3 ESSENTIAL OLL EUCALYPTUS OIL 0.2 ESSENTIAL OLL PINE NEEDLE OIL 0.1 ESSENTIAL OIL PEPPERMINT OLL 0.1 ESSENTIAL OLL TOTAL 100.0 Example 4 BABY MOISTURISING LOTION The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a baby moisturising lotion. INGREDIENTS % FUNCTION LANOLIN ALCOHOL 1.8 EMULSIFIER STEARIC ACLD 3.2 EMULSIFIER CETYL STEARYL ALCOHOL 1.2 SKIN CONDITIONER METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE OLIVE OLL 7.6 SKIN CONDITIONER GLYCERIN 4.0 HUMECTANT PURIFIED WATER 62.0 SOLVENT LAURYL ALCOHOL 0.5 EMULSIFIER FRACTIONATED COCONUT OIL 0.4 SUSPENSION AGENT ALOE VERA 8.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 3.0 HERBAL ACTIVE AVOCADO OLL 1.4 SKIN CONDITIONER WHEATGERM OLL 1.0 SKIN CONDITIONER MACADAMIA OLL 1.0 SKIN CONDITIONER APPLE OLL 0.4 ESSENTIAL OIL CHAMOMLLE EXTRACT 1-1 2.0 HERBAL ACTIVE CALENDULA EXTRACT 1-1 2.0 HERBAL ACTIVE ORANGE OIL 0.3 ESSENTIAL OLL TOTAL 100.0 Example 5 BABY WASH The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a baby wash solution. INGREDIENTS % FUNCTION PURIFIED WATER 50.0 SOLVENT SODIUM LAURYL ETHER SULPHATE 12.5 ANIONIC EMULSIFYING AGENT COCOAMIDOPROPYL BETAINE 8.0 ANTISTATIC AGENT FRACTIONATED COCONUT OIL 6.5 SUSPENSION AGENT ALOE VERA JUICE 10.0 HERBAL ACTIVE GLYCERIN 5.0 HUMECTANT VIRGIN OLIVE OLL 2.0 SKIN CONDITIONER CENTIPEDA PLANT EXTRACT 1-1 2.5 HERBAL ACTIVE CHAMOMILE EXTRACT 1-1 2.5 HERBAL ACTIVE APPLE OLL 0.7 ESSENTIAL OLL METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE PROPYL HYDROXYBENZOATE 0.1 PRESERVATIVE TOTAL 100.0 Example 6 HERBAL & MINERAL TOOTHPASTE The plant extract of Example 1 was mixed with the ingredients listed below. This composition is suitable for use as a toothpaste. INGREDIENTS % FUNCTION CALCIUM CARBONATE 48.0 ABRASIVE PURIFIED WATER 21.82 SOLVENT GLYCERIN 22.0 HUMECTANT SILICA 1.6 ABRASIVE SODIUM LAURYL SULPHATE 2.0 DETERGENT CELLULOSE GUM 0.77 BINDER CENTIPEDA PLANT EXTRACT 2.1 HERBAL ACTIVE EUCALYPTUS OLL 0.2 ESSENTIAL OLL PEPPERMINT OLL 0.3 ESSENTIAL OLL CHLOROPHYLL 0.01 DEODORIZING AGENT HYDROGENATED CASTOR OLL 1.2 SUSPENSION AGENT TOTAL 100.0 Example 7 DEODORANT - ALUMINIUM FREE Antiperspirant The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition is suitable for use as an antiperspirant. INGREDIENTS A ° FUNCTION PURIFIED WATER 20.0 SOLVENT ETHANOL 70.0 SOLVENT ZINC PHENOSULFONATE 2.0 ASTRINGENT ZINC CHLORIDE 2.0 ANTISEPTIC TRICLOSAN 0.2 ANTIBACTERIAL ALLANTOLN 0.2 HEALING AGENT EUCALYPTUS OLL 0.18 ANTISEPTIC TEA TREE OLL 0.2 GERMICIDE PINE NEEDLE OLL 0.2 DEODORANT PINEAPPLE EXTRACT 1-1 1.0 ANTI-INFLAMMATORY LEMON EXTRACT 1-1 1.0 SKIN FRESHENER CHLOROPHYLL 0.02 DEODORIZING AGENT CENTIPEDA PLANT EXTRACT 1-1 3.0 HERBAL ACTIVE TOTAL 100.0 Example 8 MEN'S FACIAL SCRUB The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a facial scrub. INGREDIENTS % FUNCTION OLIVE OIL 2.0 SKIN CONDITIONER LANOLIN ALCOHOL 1.4 EMULSIFIER GRAPESEED OLL 4.2 SKIN CONDITIONER STEARIC ACID 3.7 EMULSIFIER CETYL STEARYL ALCOHOL 1.9 SKIN CONDITIONER METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE CITRIC ACLD 0.5 PRESERVATIVE FRACTIONATED COCONUT OLL 9.5 SUSPENSION AGENT COCOAMIDOPROPYL BETAINE 4.5 WETTING AGENT LECITHIN 1.2 ANTIOXIDANT ALOE VERA 10.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 9.3 HERBAL ACTIVE ALMOND MEAL 3.0 HERBAL ACTIVE PURIFIED WATER 48.0 SOLVENT ORANGE OLL 0.4 ESSENTIAL OLL GRAPEFRUIT OLL 0.2 ESSENTIAL OLL TOTAL 100.0 Example 9 AFTER SHAVE HEALER The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use an aftershave. INGREDIENTS % FUNCTION ALOE VERA 20.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 15.0 HERBAL ACTIVE GLYCERIN 5.0 HUMECTANT WITCH HAZEL EXTRACT 1-1 5.0 HERBAL ACTIVE APPLE CIDER VINEGAR 1.2 SOLVENT METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE FRACTIONED COCONUT OIL 0.4 SUSPENSION AGENT LAURYL ALCOHOL 0.5 EMULSIFIER PURIFIED WATER 52.3 SOLVENT LEMON OIL 0.4 ESSENTIAL OIL TOTAL 100.0 Example 10 FOAMING SHAVE GEL The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a foaming shave gel. INGREDIENTS A ° FUNCTION FRACTIONATED COCONUTOIL 10.0 SUSPENSION AGENT COCOAMIDOPROPYL BETAINE 12.0 ANTISTATIC AGENT PURIFIED WATER 37.6 SOLVENT LAURYL ALCOHOL 0.7 EMULSIFIER OLIVE OIL 4.0 SKIN CONDITION GLYCERIN 10.0 HUMECTANT ALOE VERA 15.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 10.0 HERBAL ACTIVE MENTHOL CRYSTALS 0.1 SKIN FRESHENER LEMON OLL 0.4 ESSENTIAL OLL TEA TREE OIL 0.2 ANTISEPTIC TOTAL 100.0 Example 11 MOISTURISER For Acne Prone Skin The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a moisturiser. INGREDIENTS % FUNCTION OLIVE OIL 2.25 SKIN CONDITIONER LANOLIN ALCOHOLS 1.75 EMULSIFIER STEARIC ACLD 3.3 EMULSIFIER CETYL STEARYL ALCOHOL 1.1 SKIN CONDITIONER METHYL HYDROXYBENZOATE 0.3 PRESERVATIVE GLYCERIN 5.0 HUMECTANT PURLFLED WATER 49.7 SOLVENT ALOE VERA 1-1 25.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1 - 1 10.0 HERBAL ACTIVE TEA TREE OIL 0.5 ESSENTIAL OIL SANDALWOOD OIL 0.01 ESSENTIAL OLL GERANIUM OLL 0.09 ESSENTIAL OLL LAVENDER OIL 0.1 ESSENTIAL OLL LAURYL ALCOHOL 0.5 EMULSIFIER FRACTIONED COCONUT OLL 0.4 SUSPENSION AGENT TOTAL 100.0 Example 12 ACNE GEL The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as acne gel. INGREDIENTS % FUNCTION ALOE VERA 25.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 20.0 HERBAL ACTIVE METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE PURIFIED WATER 45.0 SOLVENT FRACTIONATED COCONUT OIL 0.7 SUSPENSION AGENT LAURYL ALCOHOL 0.8 EMULSIFIER TEA TREE OIL 0.7 ESSENTIAL OIL CAJUPUT OIL 0.5 ESSENTIAL OIL SANDALWOOD OIL 0.2 ESSENTIAL OIL CALENDULA OIL 2.5 SKIN CONDITIONER LAVENDER OIL 0.6 ESSENTIAL OLL CALENDULA EXTRACT 1-1 2.5 HERBAL ACTIVE GOLDEN SEAL EXTRACT 1-1 1.3 HERBAL ACTIVE TOTAL 100.0 Example 13 ANTI BACTERIAL FACE WASH The Centipeda plant extract of Example 1 was mixed with the ingredients listed below This composition can be applied topically and is suitable for use as a face wash in particular as an antibacterial wash INGREDIENTS % FUNCTION FRACTIONED COCONUT OIL 10 0 SUSPENSION AGENT COC-BETAINE 9 0 ANTISTATIC AGENT GLYCERIN 10 0 HUMECTANT SODRMM LAURYL ETHER SULPHATE 7 0 WETTING AGENT CITRIC ACLD 0 5 PRESERVATIVE METHYL HYDROXYBENZOATE 0 1 PRESERVATIVE ALOE VERA 10 0 HERBAL ACTIVE TEA TREE OIL 0 1 ESSENTIAL OLL THYME OIL 0 1 ESSENTIAL OLL THYME EXTRACT 1-1 2 5 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 10 0 HERBAL ACTIVE CALENDULA EXTRACT 1 - 1 5 0 HERBAL ACTIVE CAJUPUT OIL 0 2 ESSENTIAL OIL PURIFIED WATER 35 5 SOLVENT TOTAL 100 0 Example 14 REVIVE SHOWER GEL The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition is suitable for use as a shower gel. INGREDIENTS % FUNCTION PURLFLED WATER 32.8 SOLVENT SODIUM LAURYL ETHER SULPHATE 15.0 EMULSIFYING AGENT COCAMIDOPROPYL BETAINE 12.0 WETTING AGENT FRACTIONED COCONUT OIL 9.0 SUSPENSION AGENT ALOE VERA JUICE 10.0 HERBAL ACTIVE GLYCERIN 8.0 HUMECTANT OLIVE OIL 3.4 SKIN CONDITIONER AVOCADO OIL 1.5 SKIN CONDITIONER WHEATGERM OIL 1.2 SKIN CONDITIONER LEMON GRASS OIL 0.4 ESSENTIAL OLL PATCHOULI OLL 0.2 ESSENTIAL OLL ROSEMARY OLL 0.2 ESSENTIAL OLL CITRIC ACLD 1.3 PRESERVATIVE CENTIPEDA PLANT EXTRACT 1-1 5.0 HERBAL ACTIVE TOTAL 100.0 Example 15 KALMING CREAM The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a kalming cream. INGREDEENTS % FUNCTION CETYL STEARYL ALCOHOL 8.5 SKIN CONDITIONER CETOMACROGOL 1000 1.6 EMULSIFIER OLIVE OIL 4.3 SKIN CONDITIONER GRAPESEED OIL 3.7 SKIN CONDITIONER GLYCERIN 3.0 HUMECTANT METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE CENTIPEDA PLANT EXTRACT 1-1 6.0 HERBAL ACTIVE PANTOTHENIC ACLD 0.3 ACTIVE MACADAJVΠA OLL 2.1 SKIN CONDITIONER ROSEMARY OLL 0.4 ESSENTIAL OIL GERANLUM OLL 0.5 ESSENTIAL OLL PEPPERMINT OLL 0.3 ESSENTIAL OLL BASLL OLL 0.1 ESSENTIAL OLL EVENLNG PRIMROSE OLL 2.1 SKIN CONDITIONER CITRIC ACLD 0.5 PRESERVATIVE PURIFIED WATER 45.5 SOLVENT ALOE VERA 20.0 HERBAL ACTIVE FRACTIONED COCONUT OLL 0.4 SUSPENSION AGENT LAURYL ALCOHOL 0.5 EMULSIFIER TOTAL 100.0 Example 16 SOOTHING MASSAGE OLL RUB The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a massage oil rub. INGREDIENTS A ° FUNCTION OLIVE OLL 30.0 SKIN CONDITIONER GRAPESEED OIL 39.3 SKIN CONDITIONER AVOCADO OIL 5.0 SKIN CONDITIONER ALMOND OLL 3.0 SKIN CONDITIONER MACADAMIA OIL 6.0 SKIN CONDITIONER LAVENDER OLL 0.4 ESSENTIAL OLL JUNIPER OLL 0.2 ESSENTIAL OLL ROSEMARY OIL 0.2 ESSENTIAL OLL ORANGE OIL 0.8 ESSENTIAL OLL JOJOBA OIL 4.0 SKIN LUBRICANT CUAIACWOOD OLL 0.4 ESSENTIAL OIL ETHANOL 4.0 SOLVENT WHEATGERM OLL 1.7 SKIN CONDITIONER CENTIPEDA PLANT EXTRACT 1-1 5.0 HERBAL ACTIVE TOTAL 100.0 Example 17 RELAXING BATH OIL-FOAMING The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a foaming bath oil. INGREDIENTS % FUNCTION GLYCERIN 20.0 HUMECTANT PURIFIED WATER 18.3 SOLVENT ALOE VERA JUICE 15.0 HERBAL ACTIVE SODIUM LAURYL ETHER SULPHATE 15.0 WETTING AGENT FRACTIONED COCONUT OLL 8.0 SUSPENSION AGENT OLIVE OLL 5.0 SKIN CONDITIONER METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE CENTIPEDA PLANT EXTRACT 1-1 10.0 HERBAL ACTIVE CHAMOMILE EXTRACT 5.2 HERBAL ACTIVE SANDALWOOD OIL 0.5 ESSENTIAL OLL YLANG YLANG OIL 0.8 ESSENTIAL OLL ROSE OLL 0.3 ESSENTIAL OLL GERANIUM OLL 0.4 ESSENTIAL OLL LAVENDER OLL 0.8 ESSENTIAL OLL ORANGE OLL 0.5 ESSENTIAL OLL TOTAL 100.0 Example 18 HEALING CREAM The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically as a healing cream. INGREDIENTS % FUNCTION OLIVE OIL 7.5 SKIN CONDITIONER CETYL STEARYL ALCOHOL 10.0 SKIN CONDITIONER CETOMACROHOL 1000 1.5 EMULSIFIER METHYL HYDROXYBENZOATE 0.3 PRESERVATIVE PROPYL HYDROXYBENZOATE 0.1 PRESERVATIVE GLYCERIN 5.6 HUMECTANT PURIFIED WATER 55.0 SOLVENT ALOE VERA 3.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 3-1 7.0 HERBAL ACTIVE WATTLE EXTRACT 3-1 2.0 HERBAL ACTIVE CAJUPUT OLL 0.4 ESSENTIAL OIL TEA TREE OLL 1.0 ESSENTIAL OLL LAVENDER OLL 0.6 ESSENTIAL OLL SANDALWOOD OIL 1.0 ESSENTIAL OLL CALENDULA EXTRACT 3-1 2.1 HERBAL ACTIVE GOLDEN SEAL EXTRACT 1-1 2.0 HERBAL ACTIVE LAURYL ALCOHOL 0.5 EMULSIFIER FRACTIONATED COCONUT OLL 0.4 SUSPENSION AGENT TOTAL 100.0 Example 19 BLACK HEAD REMOVER The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a black head remover. INGREDIENTS A FUNCTION PURIFIED WATER 33.1 SOLVENT ALOE VERA 15.0 HERBAL ACTIVE ETHANOL 25.0 SOLVENT HYDROGENATED CASTER OIL 0.9 SUSPENSION AGENT CENTIPEDA PLANT EXTRACT 15.0 HERBAL ACTIVE CHJCKWEED EXTRACT 1-1 1.6 HERBAL ACTIVE CHAMOMLLE EXTRACT 1-1 2.9 HERBAL ACTIVE DANDELION EXTRACT 1-1 1.7 HERBAL ACTIVE PARSLEY OLL 0.2 ESSENTIAL OLL LEMON GRASS OLL 0.4 ESSENTIAL OLL YARROW EXTRACT 2.3 HERBAL ACTIVE HONEY 1.1 EMOLLIENT APPLE CLDER VINEGAR 0.8 SOLVENT TOTAL 100.0 Example 20 UNDER EYE CARE GEL The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a cosmetic. INGREDIENTS % FUNCTION ANGELICA EXTRACT 1-1 5.0 HERBAL ACTIVE ALOE VERA JUICE 25.0 HERBAL ACTIVE CHAMOMILE EXTRACT 1-1 2.0 HERBAL ACTIVE FRACTIONATED COCONUT OIL 0.7 SUSPENSION AGENT LAURYL ALCOHOL 0.8 EMULSIFIER METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE AVOCADO OIL 1.5 SKIN CONDITIONER OLIVE OLL 3.8 SKIN CONDITIONER CENTIPEDA PLANT EXTRACT 1-1 12.0 HERBAL ACTIVE PURIFIED WATER 49.0 SOLVENT TOTAL 100.0 Example 21 EYE SURROUND BALM The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a balm. INGREDIENTS % FUNCTION CETYL STEARYL ALCOHOL 6.5 SKIN CONDITIONER CETOMACROGOL 1000 1.0 EMULSIFIER LANOLIN WAX 0.8 EMULSIFIER BEESWAX 0.6 EMULSIFIER GLYCERIN 8.0 HUMECTANT METHYL HYDROXYBENZOATE 0.4 PRESERVATIVE PURIFIED WATER 45.8 SOLVENT LECITHIN LIQUID 0.8 EMULSIFIER OLIVE OLL 5.0 SKIN CONDITIONER JOJOBA OLL 3.1 SKIN CONDITIONER EVENING PRIMROSE OLL 1.9 SKIN CONDITIONER AVOCADO OLL 1.9 SKIN CONDITIONER ALOE VERA 1-1 4.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 11.7 HERBAL ACTIVE CALENDULA EXTRACT 1 - 1 3.0 HERBAL ACTIVE WITCH HAZEL EXTRACT 1-1 1.2 HERBAL ACTIVE EYEBRIGHT EXTRACT 1-1 3.6 HERBAL ACTIVE LAURYL ALCOHOL 0.5 EMULSIFIER FRACTIONATED COCONUT OIL 0.4 SUSPENSION AGENT TOTAL 100.0 Example 22 EYE MAKE-UP REMOVER The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as an eye make-up remover. INGREDIENTS FUNCTION LANOLIN ALCOHOLS 1.8 EMULSIFIER STEARIC ACLD 3.2 EMULSIFIER CETYL STEARYL ALCOHOL 1.2 SKIN CONDITIONER OLIVE OLL 4.0 SKIN CONDITIONER METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE GLYCERIN 5.0 HUMECTANT PURIFIED WATER 55.4 SOLVENT ALOE VERA 16.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 5.0 HERBAL ACTIVE LAURYL ALCOHOL 0.5 EMULSIFIER FRACTIONATED COCONUT OLL 0.4 SUSPENSION AGENT ALMOND OLL 1.7 SKIN CONDITIONER APRICOT KERNEL OLL 2.4 SKIN CONDITIONER ELDER FLOWER EXTRACT 1 - 1 2.1 HERBAL ACTIVE HONEY 1.1 EMOLLIENT TOTAL 100.0 Example 23 HYDRATING GEL MASK For Dry Skin The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a hydrating gel mask for dry skin. INGREDDZNTS A FUNCTION PURIFIED WATER 22.7 SOLVENT ETHANOL 12.5 SOLVENT FRACTIONATED COCONUT OIL 0.5 SUSPENSION AGENT LAURYL ALCOHOL 0.6 EMULSIFIER GLYCERIN 10.0 HUMECTANT ALOE VERA 20.0 HERBAL ACTIVE OLIVE OIL 3.1 SKIN CONDITIONER HONEY 1.5 EMOLLIENT LECITHIN 1.1 ANTIOXLDANT KAOLIN 15.0 ACTIVE PURIFIED TALC 4.2 ABSORBING AGENT CUCUMBER EXTRACT 1-1 2.5 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1 - 1 6.0 HERBAL ACTIVE METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE FENNEL OLL 0.1 ESSENTIAL OIL TOTAL 100.0 Example 24 ASTRINGENT LOTION For Dry Skin The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as an astringent lotion for dry skin. INGREDIENTS A FUNCTION ETHANOL 35.0 SOLVENT PURIFIED WATER 31.5 SOLVENT GLYCERIN 5.0 HUMECTANT HYDROGENATED CASTOR OIL 0.9 SUSPENSION AGENT MENTHOL CRYSTALS 0.1 SKIN FRESHENER FRUIT ACLDS OF GRAPE, LEMON 1.6 ANTIOXLDANT LEMON OLL 0.2 ESSENTIAL OIL LLME OLL 0.4 ESSENTIAL OLL GERANIUM OLL 0.2 ESSENTIAL OLL METHYL HYDROXYBENZOATE 0.1 PRESERVATIVE CENTIPEDA PLANT EXTRACT 1-1 5.0 HERBAL ACTIVE ALOE VERA 20.0 HERBAL ACTIVE TOTAL 100.0 Example 25 NIGHT CREAM For Dry Skin The Centipeda plant extract of Example 1 was mixed with the ingredients listed below This composition can be applied topically and is suitable for use as a night cream for dry skin INGREDIENTS A FUNCTION CETYL STEARYL ALCOHOL 10 0 SKIN CONDITIONER CETOMACROGOL 1000 1 6 EMULSLFLER METHYL HYDROXYBENZOATE 0 3 PRESERVATIVE GRAPESEED OIL 8 0 SKIN CONDITIONER GLYCERIN 7 0 HUMECTANT PURLFLED WATER 45 0 SOLVENT CENTIPEDA PLANT EXTRACT 1-1 6 0 HERBAL ACTIVE ROSEMARY EXTRACT 1-1 1 0 HERBAL ACTIVE ALOE VERA 10.0 HERBAL ACTIVE ALMOND OLL 1 7 SKIN CONDITIONER AVOCADO OLL 2 1 SKIN CONDITIONER OLIVE OLL 6 0 SKIN CONDITIONER LEMON GRASS OLL 0 4 ESSENTIAL OLL, LAURYL ALCOHOL 0 5 EMULSIFIER FRACTIONATED COCONUT OLL 0 4 SUSPENSION AGENT TOTAL 100 0 Example 26 DAY CREAM For Dry Skin The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a day cream for dry skin. INGREDIENTS A FUNCTION CETYL STEARYL ALCOHOL 8.4 SKIN CONDITIONER CETOMACROGOL 1000 1.6 EMULSLFLER GRAPESEED OIL 6.5 SKIN CONDITIONER OLIVE OLL 2.0 SKIN CONDITIONER METHYL HYDROXYBENZOATE 0.4 PRESERVATIVE GLYCERIN 8.0 HUMECTANT PURLFLED WATER 52.9 SOLVENT CENTIPEDA PLANT EXTRACT 1-1 5.0 HERBAL ACTIVE ALOE VERA 10.0 HERBAL ACTIVE ORANGE BLOSSOM 0.4 ESSENTIAL OLL LETTUCE EXTRACT 1-1 2.0 HERBAL ACTIVE CALENDULA EXTRACT 1 - 1 1.9 HERBAL ACTIVE LAURYL ALCOHOL 0.5 EMULSIFIER FRACTIONATED COCONUT OIL 0.4 SUSPENSION AGENT TOTAL 100.0 Example 27 TONER For Dry Skin The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a toner for dry skin. INGREDIENTS A FUNCTION PURIFIED WATER 42.9 SOLVENT ETHANOL 20.0 SOLVENT HYDROGENATED CASTOR OIL 1.0 SUSPENSION AGENT ALOE VERA JUICE 25.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 5.0 HERBAL ACTIVE CUCUMBER EXTRACT 1-1 2.0 HERBAL ACTIVE CALENDULA EXTRACT 1-1 2.0 HERBAL ACTIVE CALENDULA OLL 1.0 SKIN CONDITIONER AVOCADO OLL 1.0 SKIN CONDITIONER FENNEL OLL 0.1 ESSENTIAL OIL TOTAL 100.0 Example 28 CLEANSER LOTION For Dry Skin The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a cleansing lotion for dry skin. INGREDffiNTS A FUNCTION LANOLIN ALCOHOLS 1.8 EMULSIFIER STEARIC ACLD 3.2 EMULSIFIER CETYL STEARYL ALCOHOL 1.2 SKIN CONDITIONER GRAPESEED OLL 5.0 SKIN CONDITIONER METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE GLYCERIN 2.0 HUMECTANT PURIFIED WATER 66.6 SOLVENT ALOE VERA 8.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 5.0 HERBAL ACTIVE LAURYL ALCOHOL 0.5 EMULSIFIER FRACTIONATED COCONUT OLL 0.4 SUSPENSION AGENT CUCUMBEREXTRACT 1-1 3.0 HERBAL ACTIVE CALENDULAEXTRACT 1-1 2.9 HERBAL ACTIVE GRAPEFRUIT OIL 0.2 ESSENTIAL OLL TOTAL 100.0 Example 29 ASTRINGENT LOTION For Normal To Oily Skin The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as an astringent lotion for normal to oily skin. INGREDIENTS A FUNCTION ETHANOL 40.0 SOLVENT PURIFIED WATER 31.5 SOLVENT HYDROGENATED CASTOR OLL 0.9 SUSPENSION AGENT METHANOL CRYSTALS 0.1 SKIN FRESHENER FRUIT ACLDS OF GRAPE, LEMON 1.6 ANTIOXIDANT LEMON OIL 0.2 ESSENTIAL OLL GRAPEFRUIT OLL 0.4 ESSENTIAL OLL WATTLE OLL 0.2 ESSENTIAL OLL METHYL HYDROXYBENZOATE 0.1 PRESERVATIVE CENTIPEDA PLANT EXTRACT 1-1 5.0 HERBAL ACTIVE ALOE VERA 20.0 HERBAL ACTIVE TOTAL 100.0 Example 30 PURIFYING GEL MASK For Normal To Oily Skin The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as purifying gel mask for normal to oily skin. INGREDIENTS A FUNCTION PURLFLED WATER 35.0 SOLVENT ETHANOL 12.3 SOLVENT FRACTIONATED COCONUT OLL 0.5 SUSPENSION AGENT LAURYL ALCOHOL 0.6 EMULSLFLER GLYCERIN 5.0 HUMECTANT ALOE VERA 15.0 HERBAL ACTIVE HONEY 2.1 EMOLLIENT LECITHIN 1.3 ANTIOXIDANT KAOLIN 15.0 ACTIVE PURLFLED TALC 4.2 ABSORBING AGENT WITCH LIAZEL EXTRACT 1-1 3.0 HERBAL ACTIVE LEMON OIL 0.1 ESSENTIAL OIL CENTIPEDA PLANT EXTRACT 1-1 5.7 HERBAL ACTIVE METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE TOTAL 100.0 Example 31 NIGHT CREAM For Normal To Oily Skin The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a night cream for normal to oily skin. INGREDIENTS A FUNCTION CETYL STEARYL ALCOHOL 10.0 SKIN CONDITIONER CETOMACROGOL 1000 1.6 EMULSIFIER METHYL HYDROXYBENZOATE 0.4 PRESERVATIVE GRAPESEED OIL 11.6 SKIN CONDITIONER GLYCERIN 5.0 HUMECTANT PURLFLED WATER 50.0 SOLVENT CENTIPEDA PLANT EXTRACT 1-1 6.0 HERBAL ACTIVE GENTIAN EXTRACT 1-1 1.4 HERBAL ACTIVE ALOE VERA 7.0 HERBAL ACTIVE ALMOND OIL 1.2 SKIN CONDITIONER AVOCADO OLL 1.5 SKIN CONDITIONER OLIVE OLL 3.0 SKIN CONDITIONER GRAPEFRUIT OLL 0.4 ESSENTIAL OLL LAURYL ALCOHOL 0.5 EMULSIFIER FRACTIONATED COCONUT OLL 0.4 SUSPENSION AGENT TOTAL 100.0 Example 32 DAY CREAM For Normal To Oily Skin The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a day cream for normal to oily skin. INGREDIENTS A FUNCTION CETYL STEARYL ALCOHOL 8.4 SKIN CONDITIONER CETOMACROGOL 1000 1.6 EMULSIFIER GRAPESEED OLL 8.0 SKIN CONDITIONER METHYL HYDROXYBENZOATE 0.4 PRESERVATIVE GLYCERIN 3.0 HUMECTANT PURIFIED WATER 58.6 SOLVENT CENTIPEDA PLANT EXTRACT 1-1 5.0 HERBAL ACTIVE ALOE VERA 10.0 HERBAL ACTIVE WATTLE OIL 0.3 ESSENTIAL OLL CALENDULA EXTRACT 1 - 1 2.8 HERBAL ACTIVE SESAME OIL 1.0 SKIN CONDITIONER LAURYL ALCOHOL 0.5 EMULSIFIER FRACTIONATED COCONUT OIL 0.4 SUSPENSION AGENT TOTAL 100.0 Example 33 TONER For Normal To Oily Skin The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a toner for normal to oily skin. INGREDD2NTS A FUNCTION PURIFIED WATER 46.0 SOLVENT ETHANOL 20.0 SOLVENT HYDROGENATED CASTOR OLL 1.0 SUSPENSION AGENT WITCH HAZEL EXTRACT 1 - 1 5.0 HERBAL ACTIVE ALOE VERA JUICE 20.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 5.0 HERBAL ACTIVE LIME OLL 0.2 ESSENTIAL OLL RED CLOVER EXTRACT 1-1 2.8 HERBAL ACTIVE TOTAL 100.0 Example 34 CLEANSER LOTION For Normal To Oily Skin The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a cleansing lotion for normal to oily skin. INGREDIENTS A FUNCTION LANOLIN ALCOHOLS 1.8 EMULSIFIER STEARIC ACID 3.2 EMULSLFLER CETYL STEARYL ALCOHOL 1.2 SKIN CONDITIONER GRAPESEED OIL 5.0 SKIN CONDITIONER METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE GLYCERIN 2.0 HUMECTANT PURIFIED WATER 55.5 SOLVENT ALOE VERA 8.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 5.0 HERBAL ACTIVE LAURYL ALCOHOL 0.5 EMULSIFIER FRACTIONATED COCONUT OIL 0.4 SUSPENSION AGENT CHAMOMILE EXTRACT 1 - 1 3.2 HERBAL AC FIVE CALENDULA EXTRACT 1 - 1 2.7 HERBAL ACTIVE WATTLE OIL 0.2 ESSENTIAL OLL TOTAL 100.0 Example 35 FOAMING CLEANSER LOTION The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a foaming cleanser lotion. INGREDIENTS A FUNCTION FRACTIONATED COCONUT OIL 10.0 SUSPENSION AGENT COCO-BETAINE 9.0 ANTISTATIC AGENT HONEY 1.0 EMOLLIENT GLYCERIN 10.0 HUMECTANT SODIUM LAURYL ETHER SULPHATE 7.0 WETTING AGENT METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE ALOE VERA 8.0 HERBAL ACTIVE LEMON OLL 0.2 ESSENTIAL OLL TEA TREE OLL 0.1 ESSENTIAL OLL PURLFLED WATER 46.5 SOLVENT CENTIPEDA PLANT EXTRACT 1-1 4.0 HERBAL ACTIVE TOTAL 100.0 Example 36 HAIR AND SCALP MOISTURISING AND CLEANSING TREATMENT The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a hair and scalp moisturising and cleansing treatment. INGREDIENTS A FUNCTION JOJOBA OLL 2.0 HAIR CONDITIONER PURIFIED WATER 46.0 SOLVENT GLYCERIN 5.0 HUMECTANT SODIUM LAURYL ETHER SULPHATE 5.0 EMULSIFYING AGENT FRACTIONATED COCONUT OLL 6.0 SUSPENSION AGENT COCOAMIDOPROPYL BETAINE 4.0 WETTING AGENT CETYL STEARYL ALCOHOL 2.5 SKIN CONDITIONER VIRGIN OLIVE OLL 3.0 SKIN/HAIR CONDITIONER LANOLIN WAX 1.5 EMULSIFIER HONEY 1.0 EMOLLIENT ALOE VERA 8.0 HERBAL ACTIVE LECITHIN LIQUID 0.5 ANTIOXIDANT ROSEMARYEXTRACT 1-1 3.0 HERBAL ACTIVE SAGE EXTRACT 1-1 2.0 HERBAL ACTIVE CHAMOMLLE EXTRACT 1-1 1.7 HERBAL ACTIVE HORSE CHESTNUT EXTRACT 1-1 2.0 HERBAL ACTIVE LAVENDEROIL 0.5 ESSENTIAL OLL WATTLE OLL 0.3 ESSENTIAL OLL METHYLHYDROXYBENZOATE 1.0 PRESERVATIVE CENTIPEDA PLANT EXTRACT 1-1 5.0 HERBAL ACTIVE TOTAL 100.0 Example 37 TREATMENT CONDITIONER Henna & Rosemary The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a treatment conditioner. INGREDIENTS A FUNCTION CETYL STEARYL ALCOHOL 6.0 SKIN CONDITIONER STEARYL ALCOHOL 3.0 EMULSIFIER METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE OLIVE OLL 4.69 SKIN CONDITIONER ALOE VERA 6.0 HERBAL ACTIVE ROSEMARY EXTRACT 3.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 7.0 HERBAL ACTIVE HENNA EXTRACT 4.0 HERBAL ACTIVE PURIFIED WATER 66.0 SOLVENT ROSEMARY OLL 0.05 ESSENTIAL OIL LAVENDER OLL 0.05 ESSENTIAL OLL TEA TREE OLL 0.01 ESSENTIAL OIL TOTAL 100.0 Example 38 CONDITIONER The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a conditioner. INGREDEENTS A FUNCTION CETYL STEARYL ALCOHOL 6.0 SKIN CONDITIONER STEARYL ALCOHOL 3.0 EMULSIFIER METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE OLIVE OIL 4.69 SKIN CONDITIONER ALOE VERA 10.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 7.0 HERBAL ACTIVE PURLFLED WATER 69.0 SOLVENT SANDALWOOD OIL 0.02 ESSENTIAL OLL GERANIUM OLL 0.02 ESSENTIAL OLL YLANG YLANG OLL 0.01 ESSENTIAL OLL LAVENDER OLL 0.05 ESSENTIAL OLL TEA TREE OLL 0.01 ESSENTIAL OLL TOTAL 100.0 Example 39 SHAMPOO For Dry Hair The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a shampoo for dry hair. INGREDIENTS % FUNCTION SODIUM LAURYL ETHER SULPHATE 12.0 EMULSIFYING AGENT FRACTIONATED COCONUT OIL 8.0 SUSPENSION AGENT COCOAMIDOPROPYL BETAINE 1 1.0 WETTING AGENT GLYCERIN 10.0 HUMECTANT OLIVE OLL 3.0 CONDITIONING AGENT PURLFLED WATER 40.615 SOLVENT METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE ALOE VERA 8.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 7.0 HERBAL ACTIVE SANDALWOOD OIL 0.005 ESSENTIAL OIL GERANIUM OIL 0.02 ESSENTIAL OIL YLANG YLANG OLL 0.01 ESSENTIAL OLL LAVENDER OLL 0.05 ESSENTIAL OIL TEA TREE OLL 0.01 ESSENTIAL OIL TOTAL 100.0 Example 40 SHAMPOO For Normal Hair The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a shampoo for normal hair. INGREDIENTS A FUNCTION SODIUM LAURYL ETHER SULPHATE 15.0 EMULSIFYING AGENT FRACTIONATED COCONUT OIL 8.0 SUSPENSION AGENT COCOAMIDOPROPYL BETAINE 1 1.0 WETTING AGENT GLYCERIN 8.0 HUMECTANT PURLFLED WATER 40.615 SOLVENT METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE ALOE VERA 10.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 1-1 7.0 HERBAL ACTIVE SANDALWOOD OIL 0.005 ESSENTIAL OLL GERANIUM OIL 0.02 ESSENTIAL OLL YLANG YLANG OLL 0.01 ESSENTIAL OLL LAVENDER OIL 0.05 ESSENTIAL OLL TEA TREE OLL 0.01 ESSENTIAL OLL TOTAL 100.0 Example 41 HAND CREAM Hand Protectant Cream The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a hand cream. INGREDffiNTS A FUNCTION CETYL STEARYL ALCOHOL 10.0 SKIN CONDITIONER CETOMACROGOL 1000 2.0 EMULSIFIER OLIVE OIL 5.0 SKIN CONDITIONER DLMETHICONE 3.0 SKIN PROTECTANT LANOLIN WAX 2.5 EMULSIFIER COCOA BUTTER 1.0 SKIN CONDITIONER BEESWAX 1.0 EMULSIFIER GLYCERIN 5.1 HUMECTANT METHYL HYDROXYBENZOATE 0.3 PRESERVATIVE PURIFIED WATER 50.0 SOLVENT CENTIPEDA PLANT EXTRACT 3-1 5.0 HERBAL ACTIVE ALOE VERA 5.6 HERBAL ACTIVE HORSETAIL EXTRACT 2-1 4.1 HERBAL ACTIVE MARSHMALLOW EXTRACT 301 3.5 HERBAL ACTIVE LEMON OLL 1.0 ESSENTIAL OIL LAURYL ALCOHOL 0.5 EMULSIFIER FRACTIONATED COCONUT OLL 0.4 SUSPENSION AGENT TOTAL 100.0 Example 42 HAND AND NAIL CREAM The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a hand and nail cream. INGREDIENTS A FUNCTION CETYL STEARYL ALCOHOL 10.0 SKIN CONDITIONER CETOMACROGOL 1000 1.6 EMULSIFIER OLIVE OIL 10.0 SKIN CONDITIONER LANOLIN WAX 2.0 EMULSIFIER GLYCERIN 5.0 HUMECTANT METHYL HYDROXYBENZOATE 0.4 PRESERVATIVE PURIFIED WATER 46.4 SOLVENT ALOE VERA 7.0 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 3-1 3.0 HERBAL ACTIVE JOJOBA OLL 2.0 SKIN CONDITIONER DLMETHICONE 1.0 SKIN PROTECT ANT HORSET ALL EXTRACT 1-1 1.4 HERBAL ACTIVE ST. JOHNS WORT EXTRACT 1.1 2.3 HERBAL ACTIVE CALENDULA EXTRACT 1 - 1 4.6 HERBAL ACTIVE CALENDULA OIL 0.9 SKIN CONDITIONER GRAPEFRUIT OIL 0.5 ESSENTIAL OLL MARSHMALLOW EXTRACT 1-1 1.0 BIOLOGICAL ADDITION LAURYL ALCOHOL 0.5 EMULSIFIER FRACTIONATED COCONUT OLL 0.4 SUSPENSION AGENT TOTAL 100.0 Example 43 BODY LOTION The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a body lotion. INGREDIENTS A FUNCTION EVENING PRIMROSE OLL 4.6 SKIN CONDITIONER OLIVE OLL 2.25 SKIN CONDITIONER LANOLIN ALCOHOLS 1.75 EMULSIFIER STEARIC ACID 3.3 EMULSIFIER EVENING PRIMROSE OLL 4.6 SKIN CONDITIONER OLIVE OLL 2.25 SKIN CONDITIONER LANOLIN ALCOHOLS 1.75 EMULSIFIER STEARIC ACLD 3.3 EMULSIFIER CETYL STEARYL ALCOHOL 1.1 SKIN CONDITIONER METHYL HYDROXYBENZOATE 0.3 PRESERVATIVE GLYCERIN 5.0 HUMECTANT PURLFLED WATER 61.7 SOLVENT ALOE VERA 2-1 13.4 HERBAL ACTIVE CENTIPEDA PLANT EXTRACT 2-1 5.0 HERBAL ACTIVE TEA TREE OLL 0.5 ESSENTIAL OIL SANDALWOOD OLL 0.01 ESSENTIAL OIL GERANIUM OLL 0.07 ESSENTIAL OLL YLANG YLANG OIL 0.02 ESSENTIAL OLL LAVENDER OIL 0.1 ESSENTIAL OLL LAURYL ALCOHOL 0.5 EMULSIFIER FRACTIONATED COCONUT OIL 0.4 SUSPENSION AGENT TOTAL 100.0 Example 44 BODY SCRUB The Centipeda plant extract of Example 1 was mixed with the ingredients listed below This composition can be applied topically and is suitable for use as a body scrub. INGREDIENTS A FUNCTION LANOLIN ALCOHOL 1.3 EMULSIFIER OLIVE OLL 3.2 SKIN CONDITIONER GRAPESEED OIL 5.6 SKIN CONDITIONER STEARIC ACID 3.7 EMULSIFIER CETYL STEARYL ALCOHOL 1.9 SKIN CONDITIONER METHYL HYDROXYBENZOATE 0.3 PRESERVATIVE FRACTIONATED COCONUT OIL 8.3 SUSPENSION AGENT COCAMLDOPROPYL BETAINE 4.7 WETTING AGENT LECITHIN 1.2 ANTIOXIDANT ALOE VERA 8.1 HERBAL ACTIVE LEMON OIL 0.7 ESSENTIAL OLL AVOCADO OIL 1.4 SKIN CONDITIONER WHEATGERM OLL 0.8 SKIN CONDITIONER GLYCERIN 4.3 HUMECTANT CENTIPEDA PLANT EXTRACT 1-1 8.7 HERBAL ACTIVE SARSAPARILLA HERB 0.8 HERBAL ACTIVE EVENING PRIMROSE SEEDS 0.6 HERBAL ACTIVE PURIFIED WATER 44.4 SOLVENT TOTAL 100.0 Example 45 VITAMIN "E" CREAM The Centipeda plant extract of Example 1 was mixed with the ingredients listed below. This composition can be applied topically and is suitable for use as a vitamin "E" cream. INGREDIENTS A FUNCTION PURIFIED WATER 50.0 SOLVENT PARAFFIN SOFT WHITE 3.1 SKIN CONDITIONER CETOMACROGOL 1000 1.2 EMULSIFIER LANOLIN WAX 1.0 EMULSIFIER GRAPESEED OIL 8.7 SKIN CONDITIONER GLYCERIN 10.2 HUMECTANT METHYL HYDROXYBENZOATE 0.2 PRESERVATIVE LAURYL ALCOHOL 0.5 EMULSIFIER FRACTIONATED COCONUT OLL 0.4 SUSPENSION AGENT ALOE VERA 10.0 HERBAL ACTIVE APRICOT KERNEL OLL 2.7 SKIN CONDITIONER TOCOPHEROL (VITAMIN E) 3.9 ANTIOXIDANT CENTIPEDA PLANT EXTRACT 1-1 8.1 HERBAL ACTIVE TOTAL 100.0 Those skilled in the art will appreciate that the invention described herein is susceptible to variations and modifications other than those specifically described. It is to be understood that the invention includes all such variations and modifications. The invention also includes all of the steps, features, compositions and compounds referred to or indicated in this specification, individually or collectively, and any and all combinations of any two or more of said steps or features.

Claims: CLALMS: 1. A composition for the treatment and prophylaxis of medical conditions and/or for use in cosmetic treatments of a human or other animal, comprising an aqueous alcoholic extract from a plant of the genus Centipeda and an acceptable carrier and/or diluent. 2. A composition according to claim 1, wherein the plant is Centipeda Cunninghamii. 3. A composition according to claim 1 or 2, wherein the aqueous alcoholic extract is an extract in 10%) ethanol/90% water to 95% ethanol/5% water. 4. A composition according to claim 3, wherein the aqueous alcoholic extract is an extract in 30% ethanol/70% water. 5. A composition according to any one of claims 1-4, wherein the extract is prepared from part or all of the plant. 6. A composition according to any one of claims 1-5, wherein the extract is prepared by maceration, percolation, infusion, decoction, oil infusion or alcohol/ethanol extraction. 7. A composition according to any one of claims 1-5, wherein the extract is prepared from dried plant material. 8. A composition according to claim 1, wherein the carrier and/or diluent is an orally or topically acceptable carrier and/or diluent. 9. A composition according to claim 8, wherein the carrier and/or diluent comprises one or more of: emulsifiers, skin protectants, skin conditioners, humectants, preservatives, solvents, herbal actives, essential oils, suspension agents, anionic emulsifying agents, astringents, antiseptics, healing agents, germicides, anti-inflammatories, skin fresheners, wetting agents, antioxidants, skin lubricants, emollients, absorbing agents, preservatives, skin/hair conditioners, abrasives, detergents, binders and/or deodorizing agents, solvents, dispersion media, fillers, solid carriers, aqueous solutions, coatings, antibacterial and antifungal agents, isotonic or absorption delaying agents. 10. A composition according to any one of the preceding claims, in the form of an ingestible tablet, buccal tablet, capsule, lozenge, cachet, wafer, a suspension in an aqueous liquid, a syrup, an elixir, or an emulsion. 11. A composition according to any one of claims 1 to 9, in the form of a mouth lotion, mouth gel or gargle solution. 12. A composition according to any one of claims 1 to 9, in the form of a liquid or semi- liquid preparation, a cream, a homogeneous viscous or sem-solid emulsion, a gel, a liniment, a lotion, an ointment, a paint, a paste, a solution, a spray, a stick or a suspension. 13. A composition according to any one of claims 1 to 12, for use in therapeutic or prophylactic treatment or cosmetic treatment of a human. 14. A composition according claim 13, wherein the treatment is topical or oral treatment. 15. A composition according to claim 13 or 14, for use in the treatment of acne, pimples, herpes, bed sores, skin irritations, cuts, psoriasis, skin sun damage, eczema, or dermatitis. 16. A composition according to claim 13 or 14, for use in the treatment of nasal irritations. 17. A composition according to claim 13 or 14, for use in diuretic treatment. 18. A composition according to claim 13 or 14, for use in the treatment of rashes, allergic reactions, inflammations, bacterial infections or gastrointestinal disorders. 19. A composition according to claim 13 or 14, for use in skin proliferation or skin disease treatment. 20. A composition according to claim 13 or 14, in the form of a deodorant, facial scrub, shaving cream or gel, eye/face cream or gel, make-up remover, toner, cleanser, shampoo, conditioner or breath freshener. 21. A method of treatment or prophylaxis of medical conditions and/or a method of cosmetic treatment of a human or other animal comprising administration of a composition comprising an aqueous alcoholic extract from a plant of the genus Centipeda combined with an acceptable carrier and/or diluent. 22. A method of treatment according to claim 21, comprising administration of a composition according to any one of claims 2 to 12. 23. A method of treatment according to claim 21, wherein the treatment is treatment of acne, pimples, herpes, bed sores, skin irritations, cuts, psoriasis, skin sun damage, eczema or dermatitis. 24. A method of treatment according to claim 21, wherein the treatment is treatment of nasal irritations. 25. A method of treatment according to claim 21 , wherein the treatment is diuretic treatment. 26. A method of treatment according to claim 21, wherein the treatment is treatment of rashes, allergic reactions, inflammations, bacterial infections or gastrointestinal disorders. 27. A method of treatment according to claim 21, wherein the treatment is treatment of skin proliferation or skin disease. 28. A method of treatment according to any one of claims 21 to 27, wherein the composition is administered to a human. 29. A method of treatment according to claim 21, comprising oral administration of an aqueous alcoholic extract from a plant of the genus Centipeda, combined with an orally suitable carrier. 30. A method of treatment according to claim 21, comprising topical administration of an aqueous alcoholic extract from a plant of the genus Centipeda, combined with a topically suitable carrier. 31. Use of a composition according to any one of claims 1-20 in the preparation of a medicament for therapeutic or prophylactic treatment of a medical condition and/or for cosmetic treatment of a human or other animal.

Inventors: CLOSE GRAEME A, CLOSE, GRAEME, A.
Applicants: AMELIO FRANK D, CLOSE GRAEME A, CLOSE, GRAEME, A., D'AMELIO, FRANK
Application year: 1998
Main classification: A61K35
IPC codes: A61K8, A61K36, A61P17, A61P37, A61P43, A61Q1, A61Q3, A61Q5, A61Q11, A61Q19