GENE THERAPY APPROACHES TO SUPPLY APOLIPOPROTEIN A-I AGONISTS AND THEIR USE TO TREAT DYSLIPIDEMIC DISORDERS

Abstract: The invention relates to genetic approaches to supply nucleotide sequences encoding modified forms of the native forms of apolipoprotein A-I (ApoA-I): mature ApoA-I, preproApoA-I and proApoA-I; including native ApoA-I modified to contain ApoA-I agonists, peptides which mimic the activity of ApoA-I; ApoA-I superagonists, peptides which exceed the activity of native ApoA-I; and modified native ApoA-I having one or more amphipathic helices replaced by the nucleotide sequences of one or more ApoA-I agonists; for the treatment of disorders associated with dyslipoproteinemia, including cardiovascular disease, atherosclerosis, restenosis, hyperlipidemia, and other disorders such as septic shock.

Description: GENE THERAPY APPROACHES TO SUPPLY APOLIPOPROTEIN A-I AGONISTS AND THEIR USE TO TREAT DYSLIPIDEMIC DISORDERS 1. INTRODUCTION The invention relates to gene therapy approaches to supply nucleotide sequences encoding modified forms of the native forms of apolipoprotein A-I (ApoA-I) i.e. , mature ApoA-I, preproApoA-I and proApoA-I; ApoA-I peptides; ApoA-I agonists and superagonists, peptides which mimic or exceed the activity of native ApoA-I; and the native ApoA-I gene for the treatment of disorders associated with dyslipoproteinemia, including cardiovascular disease, atherosclerosis, restenosis, hyperlipidemia, and other disorders such as septic shock. 2. BACKGROUND OF THE INVENTION Circulating cholesterol is carried by plasma lipoproteins — particles of complex lipid and protein composition that transport lipids in the blood. Low density lipoproteins (LDL) , and high density lipoproteins (HDL) are the major cholesterol carriers. LDL are believed to be responsible for the delivery of cholesterol from the liver (where it is synthesized or obtained from dietary sources) to extrahepatic tissues in the body. The term "reverse cholesterol transport" describes the transport of cholesterol from extrahepatic tissues to the liver where it is catabolized and eliminated. It is believed that plasma HDL particles play a major role in the reverse transport process, acting as scavengers of tissue cholesterol. The evidence linking elevated serum cholesterol to coronary heart disease is overwhelming. For example, atherosclerosis is a slowly progressive disease characterized by the accumulation of cholesterol within the arterial wall. Compelling evidence supports the concept that lipids deposited in atherosclerotic lesions are derived primarily from plasma LDL; thus, LDLs have popularly become known as the "bad" cholesterol. In contrast, HDL serum levels correlate inversely with coronary heart disease — indeed, high serum levels of HDL are regarded as a negative risk factor. It is hypothesized that high levels of plasma HDL are not only protective against coronary artery disease, but may actually induce regression of atherosclerotic plaques (e.g. , see Badimon et al., 1992, Circulation 86 (Suppl. III):86-94). Thus, HDL have popularly become known as the "good" cholesterol. 2.1. CHOLESTEROL TRANSPORT The fat-transport system can be divided into two pathways: an exogenous one for cholesterol and triglycerides absorbed from the intestine, and an endogenous one for cholesterol and triglycerides entering the bloodstream from the liver and other non-hepatic tissue. In the exogenous pathway, dietary fats are packaged into lipoprotein particles called chylomicrons which enter the bloodstream and deliver their triglycerides to adipose tissue (for storage) and to muscle (for oxidation to supply energy) . The remnant of the chylomicron, containing cholesteryl esters, is removed from the circulation by a specific receptor found only on liver cells. This cholesterol then becomes available again for cellular metabolism or for recycling to extrahepatic tissues as plasma lipoproteins. In the endogenous pathway, the liver secretes a large, very-low-density lipoprotein particle (VLDL) into the bloodstream. The core of VLDLs consists mostly of triglycerides synthesized in the liver, with a smaller amount of cholesteryl esters (either synthesized in the liver or recycled from chylomicrons) . Two predominant proteins are displayed on the surface of VLDLs, apoprotein B-100 and apoprotein E. When a VLDL reaches the capillaries of adipose tissue or of muscle, its triglycerides are extracted resulting in a new kind of particle, decreased in size and enriched in cholesteryl esters but retaining its two apoproteins, called intermediate-density lipoprotein (IDL) . In human beings, about half of the IDL particles are removed from the circulation quickly (within two to six hours of their formation) , because they bind tightly to liver cells which extract their cholesterol to make new VLDL and bile acids. The IDL particles which are not taken up by the liver remain in the circulation longer. In time, the apoprotein E dissociates from the circulating particles, converting them to LDL having apoprotein B-100 as their sole protein. Primarily, the liver takes up and degrades most of the cholesterol to bile acids, which are the end products of cholesterol metabolism. The uptake of cholesterol containing particles is mediated by LDL receptors, which are present in high concentrations on hepatocytes. The LDL receptor binds both apoprotein E and apoprotein B-100, and is responsible for binding and removing both IDLs and LDLs from the circulation. However, the affinity of apoprotein E for the LDL receptor is greater than that of apopro'tein B-100. As a result, the LDL particles have a much longer circulating life span than IDL particles — LDLs circulate for an average of two and a half days before binding to the LDL receptors in the liver and other tissues. High serum levels of LDL (the "bad" cholesterol) are positively associated with coronary heart disease. For example, in atherosclerosis, cholesterol derived from circulating LDLs accumulates in the walls of arteries leading to the formation of bulky plaques that inhibit the flow of blood until a clot eventually forms, obstructing the artery causing a heart attack or stroke. Ultimately, the amount of intracellular cholesterol liberated from the LDLs controls cellular cholesterol metabolism. The accumulation of cellular cholesterol derived from VLDLs and LDLs controls three processes: first, it reduces the cell's ability to make its own cholesterol by turning off the synthesis of HMGCoA reductase — a key enzyme in the cholesterol biosynthetic pathway. Second, the incoming LDL-derived cholesterol promotes storage of cholesterol by activating ACAT — the cellular enzyme which converts cholesterol into cholesteryl esters that are deposited in storage droplets. Third, the accumulation of cholesterol within the cell drives a feedback mechanism that inhibits cellular synthesis of new LDL receptors. Cells, 5 therefore, adjust their complement of LDL receptors so that enough cholesterol is brought in to meet their metabolic needs, without overloading. (For a review, see Brown & Goldstein, In, The Pharmacological Basis Of Therapeutics, 8th Ed., Goodman & Gilman, Pergamon Press, NY, 1990, Ch. 36, pp. 10 874-896) . 2.2. REVERSE CHOLESTEROL TRANSPORT In sum, peripheral (non-hepatic) cells obtain their cholesterol from a combination of local synthesis and the 15 uptake of preformed sterol from VLDLs and LDLs. In contrast, reverse cholesterol transport (RCT) is the pathway by which peripheral cell cholesterol can be returned to the liver for recycling to extrahepatic tissues, or excretion into the intestine in bile. The RCT pathway represents the only means 20 of eliminating cholesterol from most extrahepatic tissues, and is crucial to maintenance of the structure and function of most cells in the body. The RCT consists mainly of three steps: (a) cholesterol efflux, the initial removal of cholesterol from 25 various pools of peripheral cells; (b) cholesterol esterification by the action of lecithin: cholesterol acyltransferase (LCAT) , preventing a re-entry of effluxed cholesterol into cells; and (c) uptake/delivery of HDL cholesteryl ester to liver cells. The RCT pathway is 30 mediated by HDLS. HDL is a generic term for lipoprotein particles which are characterized by their high density. The main lipidic constituents of HDL complexes are various phospholipids, cholesterol (ester) and triglycerides. The most prominent apolipoprotein components are A-I and A-II 35 which determine the functional characteristics of HDL; furthermore minor amounts of apolipoproteins C-I, C-II, C- III, D, E, J, etc. have been observed. HDL can exist in a wide variety of different sizes and different mixtures of the above-mentioned constituents dependent on the status of remodeling during the metabolic RCT cascade. The key enzyme involved in the RCT pathway is LCAT. LCAT is produced mainly in the liver and circulates in plasma associated with the HDL fraction. Cholesteryl ester transfer protein (CETP) and another lipid transfer protein, phospholipid transfer protein (PLTP) contribute to further remodeling the circulating HDL population. CETP can move cholesteryl esters made by LCAT to other lipoproteins, particularly ApoB-containing lipoproteins, such as VLDL. HDL triglycerides can be catabolized by the extracellular hepatic triglyceride lipase, and lipoprotein cholesterol is removed by the liver via several mechanisms. Each HDL particle contains at least one copy (and usually two to four copies) of ApoA-I. ApoA-I is synthesized by the liver and small intestine as preproapolipoprotein which is secreted as a proprotein that is rapidly cleaved to generate a mature polypeptide having 243 amino acid residues. ApoA-I consists mainly of 6 to 8 different 22 amino acid repeats spaced by a linker moiety which is often proline, and in some cases consist of a stretch made up of several residues. ApoA-I forms three types of stable structures with lipids: small, lipid-poor complexes referred to as pre-beta- 1 HDL; flattened discoidal particles containing only polar lipids (phospholipid and cholesterol) referred to as pre- beta-2 HDL; and spherical particles containing both polar and nonpolar lipids, referred to as spherical or mature HDL (HDL 3 and HDL 2 ) . Most HDL in the circulating population contain both ApoA-I and ApoA-II (the second major HDL protein) and are referred to herein as the AI/AII-HDL fraction of HDL. However, the fraction of HDL containing only ApoA-I (referred to herein as the AI-HDL fraction) appear to be more effective in RCT. Certain epidemiologic studies support the hypothesis that the AI-HDL fraction is antiartherogenic. (Parra et al., 1992, Arterioscler. Thromb. 12:701-707; Decossin et al., 1997, Eur. J. Clin. Invest. 27:299-307) Although the mechanism for cholesterol transfer from the cell surface is unknown, it is believed that the lipid-poor complex, pre-beta-1 HDL is the preferred acceptor for cholesterol transferred from peripheral tissue involved in RCT. Cholesterol newly transferred to pre-beta-1 HDL from the cell surface rapidly appears in the discoidal pre-beta-2 HDL. PLTP may increase the rate of disc formation, but data indicating a role for PLTP in RCT is lacking. LCAT reacts preferentially with discoidal and spherical HDL, transferring the 2-acyl group of lecithin or other phospholipids to the free hydroxyl residue of fatty alcohols, particularly cholesterol to generate cholesteryl esters (retained in the HDL) and lysolecithin. The LCAT reaction requires ApoA-I as activator; i.e. , ApoA-I is the natural cofactor for LCAT. The conversion of cholesterol to its ester seσuestered in the HDL prevents re-entry of cholesterol into the cell, the result being that cholesteryl esters are destined for removal. Cholesteryl esters in the mature HDL particles in the AI-HDL fraction (i.e. , containing ApoA-I and no ApoA-II) are removed by the liver and processed into bile more effectively than those derived from HDL containing both ApoA-I and ApoA-II (the AI/AII-HDL fraction) . This may be due, in part, to the more effective binding of AI-HDL to the hepatocyte membrane. The existence of an HDL receptor has been hypothesized, and recently a scavenger receptor, SR-BI, was identified as an HDL receptor. (Acton et al., 1996, Science 271:518-520). The SR-BI is expressed most abundantly in steroidogenic tissues (e.g. , the adrenals) , and in the liver. (Landshulz et al., 1996, J. Clin. Invest. 98:984-995; Rigotti et al., 1996, J. Biol. Chem. 271:33545-33549). CETP does not appear to play a major role in RCT, and instead is involved in the metabolism of VLDL-and LDL- derived lipids. However, changes in CETP activity or its acceptors, VLDL and LDL, play a role in "remodeling" the HDL population. For example, in the absence of CETP, the HDLs become enlarged particles which are not cleared. (For reviews on RCT and HDLs, see Fielding & Fielding, 1995, J. Lipid Res. 36:211-228; Barrans et al., 1996, Biochem. Biophys. Acta. 1300:73-85; Hirano et al. , 1997, Arterioεcler . Thromb. Vase. Biol. 17 (b) : 1053-1059. 2.3. CURRENT TREATMENTS FOR LOWERING SERUM CHOLESTEROL A number of treatments are currently available for lowering serum cholesterol and triglycerides (see, e.g. , Brown & Goldstein, supra) . However, each has its own drawbacks and limitations in terms of efficacy, side-effects and qualifying patient population. Bile-acid-binding resins are a class of drugs that interrupt the recycling of bile acids from the intestine to the liver; e.g. , cholestyra ine (Questran Light ® , Bristol- Myers Squibb) , and colestipol hydrochloride (Colestid ® , The Upjohn Company) . When taken orally, these positively-charged resins bind to the negatively charged bile acids in the intestine. Because the resins cannot be absorbed from the intestine, they are excreted carrying the bile acids with them. The use of such resins, however, at best only lowers serum cholesterol levels by about 20%, and is associated with gastrointestinal side-effects, including constipation and certain vitamin deficiencies. Moreover, since the resins bind other drugs, other oral medications must be taken at least one hour before or four to six hours subsequent to ingestion of the resin; thus, complicating heart patient's drug regimens. The statins are cholesterol lowering agents that block cholesterol synthesis by inhibiting AMGCoA reductase— the key enzyme involved in the cholesterol biosynthetic pathway. The statins, e.g. , lovastatin (Mevacor ® , Merck & Co., Inc.) and pravastatin (Pravachol ® , Bristol-Myers Squibb Co.) are sometimes used in combination with bile-acid-binding resins. The statins significantly reduce serum cholesterol and LDL-serum levels, and slow progression of coronary atherosclerosis. However, serum HDL cholesterol levels are only slightly increased. The mechanism of the LDL lowering effect may involve both reduction of VLDL concentration and induction of cellular expression of LDL-receptor, leading to reduced production and/or increased catabolism of LDLs. Side effects, including liver and kidney dysfunction are associated with the use of these drugs (Physicians Desk Reference, Medical Economics Co., Inc., Montvale, N.J. 1997). Recently, the FDA has approved atorvasatatin (an HMGroA reductase inhibitor developed by Parke-Davis) (Warner Lambert) for the treatment of rare but urgent cases of familial hypercholesterolemia (1995, Scrip 20 (19):10). Niacin, or nicotinic acid, is a water soluble vitamin B-complex used as a dietary supplement and antihyperlipidemic agent. Niacin diminishes production of VLDL and is effective at lowering LDL. It is used in combination with bile-acid binding resins. Niacin can increase HDL when used at adequate doses, however, its usefulness is limited by serious side effects when used at such doses. Fibrates are a class of lipid-lowering drugs used to treat various forms of hyperlipidemia, (i.e.. elevated serum triglycerides) which may also be associated with hypercholesterolemia. Fibrates appear to reduce the VLDL fraction and modestly increase HDL—however the effects of these drugs on serum cholesterol is variable. In the United States, fibrates have been approved for use as antilipidemic drugs but have not received approval as hypercholerolemia agents. For example, clofibrate (Atromid-S ® , Wyeth-Ayerest Laboratories) is an antilipidemic agent which acts (via an unknown mechanism) to lower serum triglycerides by reducing the VLDL fraction. Although serum cholesterol may be reduced in certain patient subpopulations, the biochemical response to the drug is variable, and is not always possible to predict which patients will obtain favorable results. Atromid-S ® has not been shown to be effective for prevention of coronary heart disease. The chemically and pharmacologically related drug, gemfibrozil (Lopid ® , Parke- Davis) is a lipid regulating agent which moderately decreases serum triglycerides and VLDL cholesterol, and increases HDL cholesterol — the HDL 2 and HDL 3 subtractions as well as both ApoA-I and A-II (i.e. , the AI/AII-HDL fraction) . However, the lipid response is heterogeneous, especially among different patient populations. Moreover, while prevention of coronary heart disease was observed in male patients between 40-55 without history or symptoms of existing coronary heart disease, it is not clear to what extent these findings can be extrapolated to other patient populations (e.g. , women, older and younger males) . Indeed, no efficacy was observed in patients with established coronary heart disease. Serious side-effects are associated with the use of fibrates including toxicity such as malignancy, (especially gastrointestinal cancer) , gallbladder disease and an increased incidence in non-coronary mortality. These drugs are not indicated for the treatment of patients with high LDL or low HDL as their only lipid abnormality (Physicians' Desk Reference, 1997, Medical Economics Co., Inc., Montvale, N.J.) Oral estrogen replacement therapy may be considered for moderate hypercholesterolemia in post-menopausal women. However, increases in HDL may be accompanied with an increase in triglycerides. Estrogen treatment is, of course, limited to a specific patent population (postmenopausal women) and is associated with serious side effects including induction of malignant neoplasms, gall bladder disease, thromboembolic disease, hepatic adenoma, elevated blood pressure, glucose intolerance, and hypercalcemia. Thus, there is a need to develop safer drugs that are efficacious in lowering serum cholesterol, increasing HDL serum levels, preventing coronary heart disease, and/or treating existing disease. 2.4. APOA-I AS A TARGET None of the currently available drugs for lowering cholesterol safely elevate HDL levels and stimulate RCT — most appear to operate on the cholesterol transport pathway, modulating dietary intake, recycling, synthesis of cholesterol, and the VLDL population. While it is desirable to find drugs that stimulate cholesterol efflux and removal, several potential targets in the RCT exist — e.g. , LCAT, HDL and its various components (ApoA-I, ApoA-II and phospholipids) , LTP, and CETP — and it is not known which target would be most effective at achieving desirable lipoprotein profiles and protective effects. Perturbation of any single component in the RCT pathway ultimately affects the composition of circulating lipoprotein populations, and the efficiency of RCT. Several lines of evidence based on data obtained in vivo implicate the HDL and its major protein component, ApoA- I, in the prevention of atherosclerotic lesions, and potentially, the regression of plaques — making these attractive targets for therapeutic intervention. First, an inverse correlation exists between serum ApoA-I (HDL) concentration and atherogenesis in man (Gordon & Rifkind, 1989, N. Eng. J. Med. 321:1311-1316; Gordon et al., 1989, Circulation 79:8-15). Indeed, specific subpopulations of HDL have been associated with a reduced risk for atherosclerosis in humans (Miller, 1987, Amer. Heart 113:589-597; Cheung et al., 1991, Lipid Res. 32:383-394). Second, animal studies support the protective role of ApoA-I (HDL) . Treatment of cholesterol fed rabbits with ApoA-I or HDL reduced the development and progression of plaque (fatty streaks) in cholesterol-fed rabbits. (Koizumi et al., 1988, J. Lipid Res. 29:1405-1415; Badimon et al., 1989, Lab. Invest. 60:455-461; Badimon et al., 1990, J. Clin. Invest. 85:1234-1241). However, the efficacy varied depending upon the source of HDL (Beitz et al., 1992, Prostaglandins, Leukotrienes and Essential Fatty Acids 47:149-152; Mezdour et al. , 1995, Atherosclerosis 113:237- 246) . Third, direct evidence for the role of ApoA-I was obtained from experiments involving transgenic animals. The expression of the human gene for ApoA-I transferred to mice genetically predisposed to diet-induced atherosclerosis protected against the development of aortic lesions (Rubin et al., 1991, Nature 353:265-267). The ApoA-I transgene was also shown to suppress atherosclerosis in ApoE-deficient mice and in Apo(a) transgenic mice (Paszty et al., 1994, J. Clin. Invest. 94:899-903; Plump et al. , 1994, Proc. Natl. Acad. Sci. USA 91:9607-9611, Lin et al., 1994, J. Lipid Res. 35:2263-2266). Similar results were observed in transgenic rabbits expressing human ApoA-I (Duverger, 1996, Circulation 94:713-717; Duverger et al. , 1996, Arterioscler . Thromb. Vase. Biol. 16:1424-1429; Emmanuel et al., 1997, Artheriosclerosis 1035:144), and in transgenic rats where elevated levels of human ApoA-I protected against atherosclerosis and inhibited restenosis following balloon angioplasty (Burkey et al., 1992, Circulation, Supplement I, 86:1-472, Abstract No. 1876; Burkey et al., 1995, J. Lipid Res. 36:1463-1473). The AI-HDL appear to be more efficient at RCT than the AI/AII-HDL fraction. Studies with mice transgenic for human ApoA-I or ApoA-I and ApoA-II (AI/AII) showed that the protein composition of HDL significantly affects its role — AI-HDL is more anti-atherogenic than AI/AII-HDL (Schultz et al., 1993, Nature 365:762-764). Parallel studies involving transgenic mice expressing the human LCAT gene demonstrate that moderate increases in LCAT activity significantly change lipoprotein cholesterol levels, and that LCAT has a significant preference for HDL containing ApoA-I (Francone et al., 1995, J. Clinic. Invest. 96:1440-1448; Beard et al., 1997, Nature Medicine 3,7:744-749). While these data support a significant role for ApoA-I in activating LCAT and stimulating RCT, additional studies demonstrate a more complicated scenario: a major component of HDL that modulates efflux of cell cholesterol is the phospholipid (Fournier et al., 1996, J. Lipid Res. 37:1704-1711). In view of the potential role of HDL, i.e.. both ApoA-I and its associated phospholipid, in the protection against atherosclerotic disease, human clinical trials utilizing recombinantly produced ApoA-I were commenced, discontinued and apparently recommenced by UCB Belgium (Pharma Projects, October 27, 1995; IMS R&D Focus, June 30, 1997; Drug Status Update, 1997, Atherosclerosis 2(6):261- 265) ; see also M. Eriksson at Congress, "The Role of HDL in Disease Prevention," Nov. 7-9, 1996, Fort Worth; Lacko & Miller, 1997, J. Lipid Res. 38:1267-1273; and W094/13819) and were commenced and discontinued by Bio-Tech (Pharmaprojects, April 7, 1989). Trials were also attempted using ApoA-I to treat septic shock (Opal, "Reconstituted HDL as a Treatment Strategy for Sepsis," IBCs 7th Annual International Conference on Sepsis, April 28-30, 1997, Washington, D.C.; Gouni et al., 1993, J. Lipid Res. 94:139-146; Levine WO96/04916) . However, there are many pitfalls associated with the production and use of ApoA-I making it less than ideal as a drug; e.g. , ApoA-I is a large protein that is difficult and expensive to produce; significant manufacturing and reproducibility problems must be overcome with respect to stability during storage, delivery of an active product and half-life in vivo. In view of these drawbacks, attempts have been made to prepare peptides that mimic ApoA-I. Since the key activities of ApoA-I have been attributed to the presence of multiple repeats of a unique secondary structural feature in the protein — a class A amphipathic α-helix (Segrest, 1974, FEBS Lett. 38:247-253), most efforts to design peptides which mimic the activity of ApoA-I have focused on designing peptides which form class A-type amphipathic α-helices. Class A-type amphipathic α-helices are unique in that positively charged amino acid residues are clustered at the hydrophobic-hydrophilic interface and negatively charged amino acid residues are clustered at the center of the hydrophilic face. Furthermore, Class A jS-helical peptides have a hydrophobic angle of less than 180° (Segrest et al., PROTEINS, 1990; Structure, Function and Genetics 8:103-117). The initial de novo strategies to design ApoA-I mimics were not based upon the primary sequences of naturally occurring apolipoproteinε, but rather upon incorporating these unique Class A helix features into the sequences of the peptide analogues as well as some of the properties of the ApoA-I domains (see, e.g. , Davidson et al., 1996, Proc. Natl. Acad. Sci. USA 93:13605-13610; Rogers et al., 1997, Biochemistry 36:288-300; Lins et al., 1993, Biochim. Biophys. Acta 5 biomembranes 1151:137-142; Ji and Jonas, 1995, J. Biol. Chem. 270:11290-11297; Collet et al., 1997, Journal of Lipid Research, 38:634-644; Sparrow and Gotto, 1980, Ann. N.Y. Acad. Sci. 348:187-211; Sparrow and Gotto, 1982, CRC Crit. Rev. Biochem. 13:87-107; Sorci-Tho as et al., 1993, J. Biol. 0 Chem. 268:21403-21409; Wang et al., 1996, Biochim. Biophys. Acta 174-184; Minnich et al., 1992, J. Biol. Chem. 267:16553- 16560; Holvoet et al., 1995, Biochemistry 34:13334-13342; Sorci-Thomas et al., 1997, J. Biol. Chem. 272 (11) : 7278-7284 ; and Frank et al., 1997, Biochemistry 36:1798-1806). 5 In one study, Fukushi a et al. synthesized a 22- residue peptide composed entirely of Glu, Lys and Leu residues arranged periodically so as to form an amphipathic cn-helix with equal hydrophilic and hydrophobic faces ("ELK peptide") (Fukushima et al., 1980, J. Biol. Chem. 255:10651- 0 10657; Fukushima et al. , 1979, J. Amer. Chem. Soc. 101(13) :3703-3704) . The ELK peptide shares 41% sequence homology with the 198-219 fragment of ApoA-I. As studied by quantitative ultrafiltration, gel permeation chromatography and circular dichroism, this ELK peptide was shown to 5 effectively associate with phospholipids and mimic some of the physical and chemical properties of ApoA-I (Kaiser et al., 1983, Proc. Natl. Acad. Sci. USA 80:1137-1140; Kaiser et al., 1984, Science 223:249-255; Fukushima et al., 1980, supra ; Nakagawa et al., 1985, J. Am. Chem. Soc. 107:7087- 30 7092) . Yokoyama et al. concluded from such studies that the crucial factor for LCAT activation is simply the presence of a large enough amphipathic structure (Yokoyama et al., 1980, J. Biol. Chem. 255 (15) -.7333-7339) . A dimer of this 22- residue peptide was later found to more closely mimic ApoA-I 35 than the monomer; based on these results, it was suggested that the 44-mer which is punctuated in the middle by a helix breaker (either Gly or Pro) , represented the minimal functional domain in ApoA-I (Nakagawa et al., 1985, supra) . Another study involved model amphipathic peptides called "LAP peptides" (Pownall et al. , 1980, Proc. Natl. Acad. Sci. USA 77 (b) : 3154-3158 ; Sparrow et al. , 1981, In: Peptides: Synthesis-Structure-Function, Roch and Gross, Eds., Pierce Chem. Co., Rockford, IL, 253-256). Based on lipid binding studies with fragments of native apolipoproteins, several LAP peptides were designed, designated LAP-16, LAP-20 and LAP-24 (containing 16, 20 and 24 amino acid residues, respectively) . These model amphipathic peptides share no sequence homology with the apolipoproteins and were designed to have polar faces organized in a manner unlike the class A- type amphipathic helical domains associated with apolipoproteins. From these studies, the authors concluded that a minimal length of 20 residues is necessary to confer lipid-binding properties to model amphipathic peptides. Studies with mutants of LAP20 containing a proline residue at different positions in the sequence indicated that a direct relationship exists between lipid binding and LCAT activation, but that the helical potential of a peptide alone does not lead to LCAT activation (Ponsin et al., 1986 J. Biol. Chem. 261 (20) : 9202-9205) . Moreover, the presence of this helix breaker (Pro) close to the middle of the peptide reduced its affinity for phospholipid surfaces as well as its ability to activate LCAT. While certain of the LAP peptides were shown to bind phospholipids (Sparrow et al., supra) , controversy exists as to the extent to which LAP peptides are helical in the presence of lipids (Buchko et al., 1996, J. Biol. Chem. 271(6) : 3039-3045; Zhong et al., 1994, Peptide Research 7 (2) : 99-106) . Segrest et al. have synthesized peptides composed of 18 to 24 amino acid residues that share no sequence homology with the helices of ApoA-I (Kannelis et al., 1980, J. Biol. Chem. 255 (3) : 11464-11472 ; Segrest et al. , 1983, J. Biol. Chem. 258:2290-2295). The sequences were specifically designed to mimic the amphipathic helical domains of class A exchangeable apolipoproteins in terms of hydrophobic moment (Eisenberg et al., 1982, Nature 299:371-374) and charge distribution (Segrest et al., 1990, Proteins 8:103-117; U.S. Patent No. 4,643,988). One 18-residue peptide, the "18A" peptide, was designed to be a model class-A α-helix (Segrest et al., 1990, supra) . Studies with these peptides and other peptides having a reversed charged distribution, like the "18R" peptide, have consistently shown that charge distribution is critical for activity; peptides with a reversed charge distribution exhibit decreased lipid affinity relative to the 18A class-A mimics and a lower helical content in the presence of lipids (Kanellis et al., 1980, J. Biol. Chem. 255:11464-11472; Anantharamaiah et al., 1985, J. Biol. Chem. 260:10248-10255; Chung et al. , 1985, J. Biol. Chem. 260:10256-10262; Epand et al., 1987, J. Biol. Chem. 262:9389-9396; Anantharamaiah et al., 1991, Adv. Exp. Med. Biol. 285:131-140). Other synthetic peptides sharing no sequence homology with the apolipoproteins which have been proposed with limited success include dimers and trimers of the 18A peptide (Anathara aiah et al., 1986, Proteins of Biological Fluids 34:63-66), GALA and EALA peptides (Subbarao et al., 1988, Proteins: Structure, Function and Genetics 3:187-198) and ID peptides (Labeur et al., 1997, Arteriosclerosis, Thrombosis, and Vascular Biology 17:580-588) and the 18AM4 peptide (Brasseur et al., 1993, Biochem. Biophys. Acta 1170:1-7) . A "consensus" peptide containing 22-amino acid residues based on the sequences of human ApoA-I has also been designed (Venkatachalapathi et al., 1991, Mol. Conformation and Bio. Interactions B: 585-596). The sequence was constructed by identification of the most prevalent residue at each position of the helices of ApoA-I. Like the peptides described above, the helix formed by this peptide has positively charged amino acid residues clustered at the hydrophilic:hydrophobic interface, negatively charged amino acid residues clustered at the center of the hydrophilic face and hydrophobic angle of less than 180°. While a dimer of this peptide is somewhat effective in activating LCAT, the monomer exhibited poor lipid binding properties (Vekatachalapathi et al., 1991, supra) . Based primarily on in vitro studies with the peptides described above, a set of "rules" has emerged for designing peptides which mimic the function of ApoA-I. Significantly, it is thought that an amphipathic α-helix having positively charged residues clustered at the hydrophilic-hydrophobic interface and negatively charged amino acid residues clustered at the center of the polar face is required for lipid affinity and LCAT activation (Venkatachalapathi et al., 1991, supra) . Anantharamaiah et al., have also indicated that the negatively charged Glu residue at position 13 of the consensus 22-mer peptide, which is positioned within the hydrophobic face of the α-helix, plays an important role in LCAT activation (Anantharamaiah et al., 1991, supra) . Furthermore, Brasseur has indicated that a hydrophobic angle (pho angle) of less than 180° is required for optimal lipid-apolipoprotein complex stability, and also accounts for the formation of discoidal particles having the peptides around the edge of a lipid bilayer (Brasseur, 1991, J. Biol. Chem. 66 (24) : 16120-16127) . Rosseneu et al., have also insisted that a hydrophobic angle of less than 180° is required for LCAT activation (W093/25581) . However, despite these "rules" to date, no one has designed or produced a peptide as active as ApoA-I — the best having less than 40% of the activity of ApoA-I as measured by the LCAT activation assay described herein. None of the peptide "mimetics" described in the literature have not been demonstrated to be useful as a drug. In view of the foregoing, there is a need for the development of a stable ApoA-I agonist that mimics the activity of ApoA-I, which is relatively simple and cost- effective to produce. However, the "rules" for designing efficacious ApoA-I mimetics have not been unraveled and the principles to devise organic molecules with the function of ApoA-I are unknown. 3. SUMMARY OF THE INVENTION The invention relates to genetic approaches to supply nucleotide sequences encoding modified forms of the native forms of apolipoprotein A-I (ApoA-I) : mature ApoA-I, preproApoA-I and proApoA-I; including native ApoA-I modified to contain ApoA-I agonists, peptides which mimic the activity of ApoA-I; ApoA-I superagonists, peptides which exceed the activity of native ApoA-I; and modified native ApoA-I having one or more amphipathic helices replaced by the nucleotide sequences of one or more ApoA-I agonists; for the treatment of disorders associated with dyslipoproteinemia, including cardiovascular disease, atherosclerosis, restenosis, hyperlipidemia, and other disorders such as septic shock. In particular, the invention relates to genetic approaches to supply nucleotide sequences encoding modified native forms of the ApoA-I protein and peptides which act as ApoA-I agonists capable of forming amphipathic α-helices (in the presence of lipids) that approach or surpass the activity of native ApoA-I, e.g. , formation of pre-β-like or HDL-like complexes, promotion of cholesterol efflux, binding to lipids, increasing the activity of LCAT, and increasing serum levels of HDL. The present invention also relates to nucleotide sequences encoding a modified native ApoA-I having one or more amphipathic helices replaced by the nucleotide sequences of one or more ApoA-I agonists. The present invention relates to DNA vectors or cassettes that contain nucleotide sequences encoding modified ApoA-I or peptides which act as ApoA-I agonists or superagonists. The invention further relates to DNA vectors or cassettes that contain nucleotide sequences encoding modified forms of the native ApoA-I gene. The DNA vectors or cassettes may encode modified forms of native ApoA-I or ApoA- I agonists under the control of strong regulatory elements which result in high levels of ApoA-I expression. To increase efficiency of production, the DNA expression vectors or cassettes may be designed to encode multiple units of the peptide, e.g. , the cassettes may contain nucleotide sequences encoding several ApoA-I peptides in tandem, separated by an internal ribosome binding site, so that several peptides may be encoded by the same cassette. The vectors or cassettes may also express ApoA-I peptides as monopolymers (repeating peptide units) or heteropolymerε (different peptide units) . The cassettes of the present invention may also additionally encode prepropeptide or propeptide ApoA-I sequences so that the peptides of the present invention are processed in the same way as the native ApoA-I protein. The present invention further relates to genetically engineered host cells which express the modified native forms of ApoA-I: mature ApoA-I, preproform or proform, peptides which mimic ApoA-I activity or the native ApoA-I gene product. The host cells may be genetically engineered in vitro or in vivo. The present invention also relates to transgenic animals engineered to express the ApoA-I peptides of the present invention. The invention also relates to in vivo delivery applications for gene therapy, including administering engineered viral vectors or liposomes which contain DNA sequences encoding ApoA-I or ApoA-I agonist peptides in monomeric or heteromeric forms. The invention relates to ex vivo gene therapy approaches to provide engineered cells derived from a patient, or a compatible host, to express modified forms of the native ApoA-I gene, ApoA-I agonists in monomeric or heteromeric form. Ex vivo gene therapy approaches may also encompass delivery of "sacs of cells" which have been genetically engineered to express the ApoA-I gene of the present invention, including, ApoA-I agonists in monomeric or heteromeric form and additional ApoA-I prosequences. In a preferred embodiment, human hepatocytes may be engineered to express ApoA-I agonists. The invention is based, in part, on the Applicants' design and discovery of peptides that mimic the helical structure and amphipathic properties of the helical amphipathic domains of ApoA-I. Surprisingly, the peptides of the invention have a ApoA-I activity, i.e. , formation of HDL- like complexes and promotion of cholesterol efflux, well above those reported for ApoA-I-derived peptides described in the literature. Indeed, some embodiments of the invention approach 100% of the activity of native ApoA-I, whereas superagonists described herein exceed the specific activity of ApoA-I . The invention is illustrated by way of working examples that describe the jln vitro and n vivo activity and efficacy of the ApoA-I peptides and agonists encoded by the nucleic acids of the present invention. Based upon the structure and activity of the exemplified embodiments, the Applicants have devised a set of "rules" which can be used to design altered or mutated forms that are also within the scope of the invention. The invention also relates to pharmaceutical formulations containing such cell lines and vectors encoding modified forms of the native ApoA-I, i.e.. mature ApoA-I, preproform of ApoA-I or proform of ApoA-I, or ApoA-I agonists (either as peptides or peptide-lipid complexes) as the active ingredient, as well as methods for preparing such formulations and their use to treat diseases associated with dyslipoproteinemia (e.g. , cardiovascular diseases, atherosclerosis) , restenosis, hyperlipidemia, hypertriglyceridemia, and/or endotoxine ia (e.g. , septic shock) . 3.1. ABBREVIATIONS As used herein, the abbreviations for the genetically encoded amino acids are as follows: 3.2. DEFINITIONS As used herein, the following terms shall have the following meanings: "Hvdrophophilic Amino Acid" refers to an amino acid having a side chain that tends to associate with the aqueous phase or polar head of a phospholipid when in the presence of lipids. Genetically encoded hydrophilic amino acids include Asp (D) , Glu (E) , His (H) , Lys (K) , Arg (R) , Asn (N) , Gin (Q) , Ser (S) and Thr (T) . "Acidic Amino Acid" refers to an amino acid having a side chain pK value of less than 7. Acidic amino acids typically have negatively charged side chains at physiological pH due to loss of a hydrogen ion. Genetically encoded acidic amino acids include Glu (E) and Asp (D) . "Basic Amino Acid" refers to an amino acid having a side chain pK value of greater than 7. Basic amino acids typically have positively charged side chains at physiological pH due to association with hydronium ion. Genetically encoded basic amino acids include Arg (R) and Lys (K) . "Polar Amino Acid" refers to an amino acid having a side chain that is uncharged at physiological pH, but which has at least one bond wherein the pair of electrons shared in common by two atoms is held more closely by one of the atoms. Genetically encoded polar amino acids include Asn (N) and Gin (Q). "Hydrophobic Amino Acid" refers to an amino acid having a side chain that tends to associate with the acyl chains of a phospholipid when in the presence of lipids. Genetically encoded hydrophobic amino acids include Phe (F) , Tyr (Y) , Trp (W) , Leu (L) , Val (V) , He (I) , Met (M) , Gly (G) , Ala (A) and Pro (P) . "Aromatic Amino Acid" refers to a hydrophobic amino acid with a side chain having at least one aromatic or heteroaromatic ring. The aromatic or heteroaromatic ring may contain one or more substituents. Genetically encoded aromatic amino acids include Phe (F) , Tyr (Y) and Trp (W) . "Nonpolar Amino Acid" refers to a hydrophobic amino acid having a side chain that is uncharged at physiological pH and which has bonds wherein the pair of electrons shared in common by two atoms is generally held equally by each at the two atoms (i.e.. the side chain is not polar) . "Aliphatic Amino Acid" refers to a hydrophobic amino acid having an aliphatic hydrocarbon side chain. Genetically encoded aliphatic amino acids include Ala (A) , Val (V) , Leu (L) and He (I) . 4. BRIEF DESCRIPTION OF THE FIGURES FIGURE 1. The nucleotide sequence (SEQ. ID NO. : ) and amino acid sequence (SEQ. ID NO. : ) for human ApoAI. FIGURE 2. Nucleotide sequences which encode core peptides of structure I (SEQ. ID NOS.: ). FIGURE 3. Nucleotide sequences which encode core peptides of structure II (SEQ. ID NOS.: ). FIGURE 4. Nucleotide sequences which encode core peptides of structure III (SEQ. ID NOS.: ). 5. DETAILED DESCRIPTION OF THE INVENTION The present invention relates to gene therapy approaches to provide nucleotide sequences encoding modified forms of the native ApoA-I gene, nucleotide sequences encoding ApoA-I agonists which mimic ApoA-I function and activity or surpass native ApoA-I function and activity, for the treatments of disorders associated with hypercholesterolemia . The nucleotide sequences of the present invention encode peptides which form amphipathic helices (in the presence of lipids) , bind lipids, form pre-/? like or HDL-like complexes, activate LCAT, increase serum HDL concentration and promote cholesterol efflux. The biological function of encoded peptides appears to correlate with their helical structures, or conversion to helical structures in the presence of lipids. At least three types of DNA vectors or cassettes can be designed and constructed in accordance with the present invention, to contain nucleotide sequences of the native human ApoA-I gene; modified forms of the native or proform of ApoA-I; nucleotide sequences encoding ApoA-I agonists in preproform and proform; and nucleotide sequences encoding ApoA-I agonists and superagonists. The DNA vectors or cassettes may also express the ApoA-I peptides as homopolymers (repeating peptide units) or heteropolymers (different peptide units) in order to increase efficiency of production. The invention further relates to genetically engineered host cells which express the ApoA-I peptide agonists of the present invention. The host cells may be engineered in vivo or .in vitro. The present invention further relates to . in vivo and in vitro gene therapy approaches to express ApoA-I peptide agonists in a host. The present invention also relates to transgenic animals engineered to express the modified forms of the native or proform of ApoA-I and ApoA-I peptide agonists of the present invention. The nucleotide sequences encoding ApoA-I agonists of the invention can be provided as naked RNA or DNA sequences, in vectors, such as viral vectors or by transfected cells. The invention includes the pharmaceutical formulations and the use of such preparations in the treatment of dyslipoproteinemia, hyperlipidemia, hypercholesterolemia, coronary heart disease, atherosclerosis, and other conditions such as endotoxinemia/septic shock. The invention is based, in part, on the Applicant's discovery that the ApoA-I agonists of the invention associate with the HDL component of plasma, and can increase the concentration of HDL and pre-/? particles. The ApoA-I agonists of the invention increase cholesterol efflux from extrahepatic tissues. The agonists are also extremely efficient at activating LCAT, and thus promote RCT. Use of the ApoA-I agonists of the invention in vivo in animal models results in an increase in serum HDL concentration. The invention is set forth in more detail in the subsections below, which describe: the nucleotide sequences encoding the native form of ApoA-I, the preproform of ApoA-I, modified forms of the native or proform of ApoA-I and ApoA-I peptide agonists, the vectors and cell lines which may be designed to express these nucleotide sequences; n vivo and ex vivo gene therapy approaches to provide these nucleotide sequences; and methods of preparation of bulk and unit dosage formulations; and methods of use. 5.1. NUCLEOTIDE SEQUENCES ENCODING ApoA-I AND ApoA-I AGONISTS The nucleotide sequences of the present invention encode ApoA-I peptides or ApoA-I agonists which are capable of forming regions of amphipathic α-helices in the presence of lipids and which mimic the activity of ApoA-I. Nucleotide sequences encoding the ApoA-I agonists and ApoA-I peptides are described herein. The present invention also encompasses nucleotide sequences encoding the full length ApoA-I gene (SEQ. ID NO.: (FIG.l)) which have been modified to enhance or increase the ApoA-I like activities of the expressed gene product, i.e. , form amphipathic helices (in the presence of lipids) , bind lipids, form pre-/S-like or HDL-like complexes, activate LCAT, increase serum HDL concentration and promote cholesterol efflux. The present invention also encompasses nucleotide sequences which encode modified forms of native ApoA-I, i.e. , nucleotide sequences encoding a modified ApoA-I having one, two or more amphipathic helices replaced by at least two Apo-I agonists. The present invention also relates to nucleotide sequences which encode modified forms of ApoA-II, ApoA-III, ApoA-IV, ApoB, ApoC-I, ApoC-II, ApoC-III, ApoD and ApoE which have been modified to encode one, two or more ApoA-I agonists of the present invention (see e.g. , Lusis, 1988, J of Lipid Res. 29:397-428, incorporated herein by reference in its entirety) . The nucleotide sequences of the present invention also encompass nucleotide sequences encoding core peptides of Structure I (e.g. , SEQ ID NO.: (FIG.2)), core peptides of Structure II (e.g. , SEQ ID NO.: (FIG.3)) or core peptides of Structure III (e.g. , SEQ ID NO. : (FIG.4) ) . The invention also encompasses: (a) DNA vectors that contain any of the foregoing ApoA-I coding sequences and/or their complements (i.e., antisense) ; (b) DNA expression vectors that contain any of the foregoing ApoA-I coding sequences operatively associated with a regulatory element that directs the expression of the coding sequences; (c) DNA expression vectors or cassettes encoding ApoA-I agonists in tandem separated by a internal ribosome binding site so that several of the same coding sequence may be expressed from the same cassette or several different coding sequences expressing different ApoA-I agonists may be expressed from the same cassette; (d) genetically engineered host cells that contain any of the foregoing ApoA-I coding sequences operatively associated with a regulatory element that directs the expression of the coding sequences in the host cell. As used herein, regulatory elements include, but are not limited to inducible and non-inducible promoters, enhancers, operators and other elements known to those skilled in the art that drive and regulate expression. Such regulatory elements include but are not limited to the cytomegalovirus hCMV immediate early gene, the early or late promoters of the SV40 adenovirus, the lac system, the trp system, the TAC system, the TRC system, the major operator and promoter regions of phage A, the control regions of the fd coat protein, the promoter for 3-phosphoglycerate kinase, the promoters of acid phosphatase, and the promoters of the yeast α-mating factors. 5.1.1. THE NATIVE APOA-I GENE The ApoA-I gene encodes the principal protein constituent of HDL and is associated with the regulation of cholesterol efflux and the serum HDL concentration. Nucleic acids encoding the ApoA-I gene of the present invention are described herein for use in gene therapy approaches for treating disorders associated with dyslipidemia. As used herein the ApoA-I gene of the present invention includes, but is not limited to: (a) a nucleic acid molecule containing the cDNA encoding human ApoA-I, the full length human ApoA-I cDNA comprises 842 nucleotides (SEQ ID NO.: (FIG.l)) (see Shoulders et al., 1983, Nucleic Acids Research 11:2827-2837, incorporated herein by reference in its entirety) in which nucleotide sequences encoding at least one of the 22 amino acid repeats are replaced by nucleotide sequences encoding the ApoA-I agonists of the present invention; (b) a nucleic acid molecule containing the genomic sequence of human ApoA-I which contains at least two introns of 185 and 588 nucleotides (see Shoulders et al., 1983, Nucleic Acids Research 11:2827-2837, incorporated herein by reference in its entirety) ; (c) a nucleic acid molecule containing the DNA sequences encoding 1 to 8 of the different 22 amino acid repeats found in the native human ApoA-I, and may further contain the DNA sequences encoding the linker or spacer moieties found between one or more of the repeats; (d) a nucleic acid molecule containing the DNA sequences encoding a modified ApoA-I in which at least one amphipathic helix is replaced by the sequence of at least one ApoA-I agonist; (e) a nucleic acid molecule containing all or a portion of (a) , (b) , (c) or (d) and additionally the DNA sequences encoding the prepropeptide segment or leader peptide which encompasses the first 18 amino acids of the amino terminus of ApoA-I. The leader peptide of human ApoA- I, 5'MKAAVLTLAVLFLTGSQA3' (SEQ. ID NO. : _) , is cleaved following secretion of ApoA-I from the host cell; (f) a nucleic acid molecule containing all or a portion of (a) , (b) , (c) , (d) or (e) and additionally the DNA sequences encoding the propeptide segment which encompasses a 6 amino acid sequence, 5'RHFWQQ3', which is cleaved by specific proteases resulting in a mature ApoA-I; and/or (g) a nucleic acid molecule containing a DNA sequence encoding a gene product functionally equivalent to an ApoA-I peptide. The term "functionally equivalent to an ApoA-I peptide" as used herein, refers to a gene product that exhibits one of the biological activities of an ApoA-I peptide including formation of amphipathic helices (in the presence of lipids) , binding to lipids, formation of pre-?- like or HDL-like complexes, activation of LCAT, increasing serum HDL concentration and promotion of cholesterol efflux. According to this aspect, the invention also includes nucleotide sequences which encode modified forms of ApoA-II, ApoA-III, ApoA-IV, ApoB, ApoC-I, ApoC-II, ApoC-III, ApoD and ApoE which have been modified to encode one, two or more ApoA-I agonists of the present invention. The invention also includes nucleic acid molecules, preferably DNA molecules, that hybridize to, and are therefore the complements of, the DNA sequences described above encoding native ApoA-I. Such hybridization conditions may be highly stringent or less highly stringent, as described above. In instances wherein the nucleic acid molecules are deoxyoligonucleotides ("oligos") , highly stringent conditions may refer, e.g., to washing in 6xSSC/0.05% sodium pyrophosphate at 37°C (for 14-base oligos), 48°C (for 17-base oligos) , 55°C (for 20-base oligos) , and 60°C (for 23-base oligos) . These nucleic acid molecules may act as ApoA-I agonist antisense molecules, useful, for example, in ApoA-I gene regulation, for and/or as antisense primers in amplification reactions of ApoA-I nucleic acid sequences. With respect to ApoA-I gene regulation, such techniques may be used to regulate, for example a hypercholesterolemia disorder. Further, such sequences may be used as part of ribozyme and/or triple helix sequences, also useful for gene regulation of mutant forms of ApoA-I which may display ApoA-I antagonist properties. Still further, such molecules may be used as components of diagnostic methods whereby, for example, the presence of a particular mutant ApoA-I allele responsible for causing a hypercholesterolemia disorder may be detected. In addition to those human sequences described herein, additional ApoA-I gene sequences can be identified and readily isolated, with out undue experimentation, by molecular biological techniques well known in the art. 5.1.2. APOA-I PEPTIDES AND APOA-I AGONISTS The nucleotide sequences may encode ApoA-I peptides or agonists which have as their main feature a "core" peptide composed of 15 to 23 amino acid residues. The amino acid sequence of this core peptide is based upon the amino acid sequences of a family of peptides which the Applicants have discovered mimic the structure and amphipathic helical properties of ApoA-I, and which exhibit specific activities that approach, or in some embodiments even exceed, the specific activity of native ApoA-I. The nucleotide sequences of the present invention encoding ApoA-I peptides and agonists may be expressed on their own, in multimeric form or may be expressed as a chimeric with nucleotide sequences encoding native or proform of ApoA-I. The ApoA-I agonists of the invention are based, in part, on the Applicants' surprising discovery that altering certain amino acid residues in the primary sequence of the 22-mer consensus sequence of Venkatachalapathi et al., 1991, Mol. Conformation and Biol. Interactions B: 585-596 (PVLDEFREKLNEELEALKQKLK; SEQ ID NO: 75; hereinafter "Segrest' s consensus 22-mer" or "consensus 22-mer") that were thought to be critical for activity yields synthetic peptides that exhibit activities that approach, or in some embodiments even exceed, the activity of native ApoA-I. In particular, the Applicants have discovered that replacing three charged amino acid residues in Segrest's consensus 22-mer peptide (Glu-5, Lys-9 and Glu-13) with a hydrophobic Leu residue provides peptides that mimic the structural and functional properties of ApoA-I to a degree that is unprecedented in the art. While not intending to be bound by any particular theory, it is believed that the helix formed by the ApoA-I agonists of the invention more closely mimics the structural and functional properties of the amphipathic helical regions of native ApoA-I that are important for effecting lipid- binding, cholesterol efflux and LCAT activation than does the α-helix formed by the ApoA-I mimetic peptides described in the literature, thereby resulting in peptides that exhibit significantly higher ApoA-I-like activity than these other peptides. Indeed, whereas many of the ApoA-I agonists of the invention approach, and in some embodiments even exceed, the activity of ApoA-I, to date, the best peptide ApoA-I mimics described in the literature — peptide 18AM4 (SEQ ID NO: 246); Corinjn et al., 1993, Biochim. Biophys. Acta 1170:8-16; Labeur et al. , Oct. 1994, Arteriosclerosis: Abstract Nos. 186 and 187; and N-acetylated, C-amidated peptide 18AM4 (SEQ ID NO: 239) (Brasseur, 1993, Biochim. Biophys. Acta 1170:1-7) — exhibit less than 4% and 11%, respectively, of the activity of ApoA-I as measured by the LCAT activation assay described herein. In an illustrative embodiment of the invention, the nucleotide sequences encode core peptides (or analogues thereof) that compose the ApoA-I agonists of the invention having the following structural formula: ( I ) 1 -X2- 3- 4-X5 " ^6"^7-Xβ " ^9~^10~^Xl~^12~^13~Xl ~^15"^16~^17-Xl8~^'19 " ^20 _ ^2l " wherein: X x is Pro (P) , Ala (A) , Gly (G) , Gin (Q) , Asp (D) or Asn (N); X 2 is an aliphatic amino acid; X 3 is Leu (L) or Phe (F) ; X 4 is an acidic amino acid; X 5 is Leu (L) or Phe (F) ; X 6 is Leu (L) or Phe (F) ; X 7 is a hydrophilic amino acid; X 8 is an acidic or a basic amino acid; X 9 is Leu (L) or Gly (G) ; X 10 is Leu (L) , Trp (W) or Gly (G) ; X X1 is a hydrophilic amino acid; X 12 is a hydrophilic amino acid; X 13 is Gly (G) or an aliphatic amino acid; X 14 is Leu (L) , Trp (W) or Gly (G) ; X 15 is a hydrophilic amino acid; X 16 is a hydrophobic amino acid; X 17 is a hydrophobic amino acid; X ιe is a basic amino acid. Gin (Q) or Asn (N) ; X 19 is a basic amino acid, Gin (Q) or Asn (N) ; X 20 is a basic amino acid; X 21 is an aliphatic amino acid; and X 22 is a basic amino acid. In the core peptides of structure (I) , the symbol "-" between amino acid residues generally designates a backbone constitutive linking function. Thus, the symbol "-" usually represents a peptide bond or amide linkage. The present invention encompasses nucleotide sequences which encode peptides which are functionally equivalent to the peptides of structure (I) , for a more detailed description see U.S. Patent Application Serial No. , page 25, line 6 to page 58, line 21, incorporated herein by reference in its entirety. In a further illustrative embodiment of the present invention, the nucleotide sequences encode core peptides (or analogues thereof) that compose the ApoA-I agonists of the invention having the following structural formula: (II) Xl-X2 _ X3 " X " X5 " X6 " X7~Xβ~X9~XlO-Xll-Xl2 " Xl3 " Xl4~ l5~ l6 " Xπ " Xl8 _ Xl9" 20" wherein: X λ is Pro (P) , Ala (A) , Gly (G) , Gin (Q) , Asn (N) or Asp (D); X 2 is an aliphatic amino acid; X 3 is Leu (L) or Phe (F) ; X 4 is Glu (E) ; X 5 is an aliphatic amino acid; X 6 is Leu (L) or Phe (F) ; X 7 is Glu (E) or Leu (L) ; X 8 is Asn (N) or Gin (Q) ; X 9 is Leu (L) ; X 10 is Leu (L) , Trp (W) or Gly (G) ; X X1 is an acidic amino acid; 12 is Arg (R) ; X 13 is Leu (L) or Gly (G) ; X 14 is Leu (L) , Phe ( F) or Gly (G) ; X 15 is Asp (D) ; X i6 is Ala (A) ; X 17 is Leu (L) ; X lθ is Asn (N) or Gin (Q) ; X 19 is a basic amino acid; X 20 is a basic amino acid; X 21 is Leu (L) ; and X 22 i s a basic amino acid. Each " - " independently designates a peptide bond or amide linkage. The present invention encompasses nucleotide sequences which encode peptides which are functionally equivalent to the peptides of structure (II) , for a more detailed description see U.S. Patent Application Serial No. page 25, line 6 to page 58, line 21, incorporated herein by reference in its entirety. In yet a further illustrative embodiment of the present invention, the nucleotide sequences encode core peptides (or analogues thereof) that compose the ApoA-I agonists of the invention having the following structural formula: (III) ι~ 2~X3~^-^5-^6~^7~X8-^9~Xl0-^ll~^12~^13-^1 ~^15~^16-^1 ~Xl8 is Pro (P) , Ala (A) , Gly (G) , Asn (N) or Gin (Q) ; X 2 is an aliphatic amino acid; X 3 is Leu (L) ; X 4 is an acidic amino acid; X 5 is Leu (L) or Phe (F) ; X 6 is Leu (L) or Phe (F) ; X 7 is a basic amino acid; X 8 is an acidic amino acid; X 9 is Leu (L) or Trp (W) ; X 10 is Leu (L) or Trp (W) ; X X1 is an acidic amino acid or Asn (N) ; X 12 is an acidic amino acid; X 13 is Leu (L) , Trp (W) or Phe (F) ; X 14 is a basic amino acid or Leu (L) ; X 15 is Gin (Q) or Asn (N) ; X 16 is a basic amino acid; X 17 is Leu (L) ; and X 1S is a basic amino acid. Each "-" independently designates a peptide bond or amide linkage. The present invention encompasses nucleotide sequences which encode peptides which are functionally equivalent to the peptides of structure (III) , for a more detailed description, see U.S. Patent Application Serial No.: , page 24, line 31 to page 58, line 3, incorporated herein by reference in its entirety. The core peptides of structure (I) , (II) and (III) are defined, in part, in terms of amino acids of designated classes. The definitions of the various designated classes are provided infra in connection with the description of mutated or altered embodiments of structure (I) , (II) and (III). All other letters in structures (I) , (II) and (III) refer to the one-letter amino acid abbreviations commonly employed in the art, as previously described. The nucleotide sequence of the peptides may be deduced as follows: While not intending to be bound by any particular theory, it is believed that the nucleotide sequences of the present invention encode peptides which form an amphipathic α-helix formed in the presence of lipids more closely mimics the structural and amphipathic properties of the helical regions of native ApoA-I that are important for effecting lipid-binding, cholesterol efflux and LCAT activation than does the α-helix formed by the peptides described in the literature, thereby resulting in peptides that exhibit significantly higher ApoA-I-like activity than these other peptides. Indeed, whereas many of the core peptides of structure (I) , (II) and (III) approach, and in some embodiments even exceed, the activity of ApoA-I, to date the best peptide ApoA-I mimic described in the literature has less than 40% of the activity of ApoA-I as measured by the LCAT activation assay described herein. While not intending to be bound by any particular theory, it is believed that certain structural and/or physical properties of the amphipathic helix formed by the core peptides of structure (I) , (II) and (III) are important for activity. These properties include the degree of amphipathicity, overall hydrophobicity, mean hydrophobicity, hydrophobic and hydrophilic angles, hydrophobic moment, mean hydrophobic moment, net charge and dipole moment. A summary of the preferred physical and structural properties of the core peptides of structure (I) , (II) and (III) is provided in TABLES II, III and IV below: TABLE II PHYSICAL PROPERTIES OF PREFERRED ApoA-I AGONISTS OF STRUCTURE ( I ) PROPERTY RANGE PREFERRED RANGE % hydrophobic amino 40 - 70 50 - 60 acids <H 0 > -0.050 to -0.070 -0.030 to -0.055 <H 0 ph °> 0.90 - 1.2 0.94 - 1.1 <μ H > 0.45 - 0.65 0.50 - 0.60 pho angle 160° - 220° 180° - 200° # positively 3 - 5 4 charged amino acids # negatively 3 - 5 charged amino acids net charge -1 to +1 0 hydrophobic cluster positions 3,6,9,10 are hydrophobic amino acids acidic cluster at least 1 acidic amino acid per turn except for last 5 C-terminal amino acids basic cluster at least 3 basic amino acids in last 5 C- terminal amino acids TABLE III PHYSICAL PROPERTIES OF PREFERRED ApoA-I AGONISTS OF STRUCTURE ( II ) PROPERTY RANGE PREFERRED RANGE % hydrophobic amino 40 - 70 50 - 60 acids <H 0 > -0.050 to -0.070 -0.030 to -0.055 <H 0 ph0 > 0.90 - 1.2 0.94 - 1.1 <PH> 0.45 - 0.65 0.50 - 0.60 pho angle 160° - 220° 180° - 200° # positively 3 - 5 4 charged amino acids # negatively charged amino acids net charge -1 to +1 0 hydrophobic cluster positions 3,6,9,10 are hydrophobic amino acids acidic cluster at least 1 acidic amino acid per turn except for last 5 C-terminal amino acids basic cluster at least 3 basic amino acids in last 5 C- terminal amino acids TABLE IV PHYSICAL PROPERTIES OF PREFERRED ApoA-I AGONISTS OF STRUCTURE (III) PROPERTY RANGE PREFERRED RANGE % hydrophobic amino 40 70 50 - 60 acids <H 0 > -0.150 to -0.070 -0.130 to -0.050 <H 0 ph0 > 0.90 - 1.2 0.95 - 1.10 <μ H > 0.55 - 0.65 0.58 - 0.62 pho angle 120° - 160° 130° - 150° # positively 3 - 5 4 charged amino acids # negatively 3 - 5 charged amino acids net charge -1 to +1 0 hydrophobic cluster positions 3,6,9,10 are hydrophobic amino acids acidic cluster at least 1 acidic amino acid per turn except for last 5 C-terminal amino acids basic cluster at least 2 basic amino acids in last 5 C- terminal amino acids The properties of the amphipathic α-helices formed by the core peptides of the invention differ significantly from the properties of class A amphipathic α-helices, particularly the class A α-helix of Segrest' s 18A and consensus 22-mer peptides. These differences are illustrated with exemplary core peptide 210 (SEQ ID NO: 210) . A comparison of the physical and structural properties of peptide 210 (SEQ ID NO: 210) and Segrest's 18A peptide (SEQ ID NO: 244) and consensus 22-mer peptide (SEQ ID NO: 75) is provided in TABLE V, below: TABLE V COMPARISON OF PROPERTIES OF EXEMPLARY CORE PEPTIDE 210 (SEQ ID NO: 210) WITH SEGREST'S CONSENSUS 22-MER (SEQ ID NO: 75) AND 18A PEPTIDE (SEQ ID NO: 244) PROPERTY 18A CONSENSUS PEPTIDE 210 22-MER # amino acids 18 22 18 # hydrophilic 9 13 9 amino acids # hydrophobic 9 9 9 amino acids % hydrophobic 50 41 50 amino acids <H 0 > -0.43 -0.293 -0.125 <H 0 ph0 > 0.778 0.960 1.081 <μ H > 0.485 0.425 0.597 pho angle 100° 100° 140° # positively 4 5 4 charged amino acids # negatively 4 6 4 charged amino acids net charge 0 -1 0 These differences in properties lead to significant differences in activity. Whereas Segrest's 18A peptide (SEQ ID NO: 244) and consensus 22-mer peptide (SEQ ID NO: 75) exhibit only 5% and 10% LCAT activation, respectively, as compared with native ApoA-I in the assays described herein, peptide 210 (SEQ ID NO: 210) exhibits 46% activation as compared with native ApoA-I in the same assays. Certain amino acid residues in the core peptides of structure (I) , (II) and (III) can be replaced with other amino acid residues without significantly deleteriously affecting, and in many cases even enhancing, the activity of the peptides. Thus, also contemplated by the present invention are mutated forms of the core peptides of structure (I) , (II) and (III) wherein at least one defined amino acid residue in the structure is substituted with another amino acid. As one of the critical features affecting the activity of the core peptides of the invention is believed to be their ability to form α-helices in the presence of lipids that exhibit the amphipathic and other properties described above, it will be recognized that in preferred embodiments of the invention, the amino acid substitutions are conservative, i.e. , the replacing amino acid residue has physical and chemical properties that are similar to the amino acid residue being replaced. For purposes of determining conservative amino acid substitutions, the amino acids can be conveniently classified into two main categories — hydrophilic and hydrophobic— depending primarily on the physical-chemical characteristics of the amino acid side chain. These two main categories can be further classified into subcategories that more distinctly define the characteristics of the amino acid side chains. For example, the class of hydrophilic amino acids can be further subdivided into acidic, basic and polar amino acids. The class of hydrophobic amino acids can be further subdivided into apolar and aromatic amino acids. The definitions of the various categories of amino acids that define structure (I) , (II) and (III) are as follows: "Hydrophophilic Amino Acid" refers to an amino acid exhibiting a hydrophobicity of less than zero according to the consensus hydrophobicity scale of Eisenberg, 1984, Ann. Rev. Biochem. 53:595-623. Genetically encoded hydrophilic amino acids include Pro (P) , Thr (T) , Ser (S) , His (H) , Glu (E) , Asn (N) , Gin (Q) , Asp (D) , Lys (K) and Arg (R) . "Acidic Amino Acid" refers to a hydrophilic amino acid having a side chain pK value of less than 7. Acidic amino acids typically have negatively charged side chains at physiological pH due to loss of a hydrogen ion. Genetically encoded acidic amino acids include Glu (E) and Asp (D) . "Basic Amino Acid" refers to a hydrophilic amino acid having a side chain pK value of greater than 7. Basic amino acids typically have positively charged side chains at physiological pH due to association with hydronium ion. Genetically encoded basic amino acids include His (H) , Arg (R) and Lys (K) . "Polar Amino Acid" refers to a hydrophilic amino acid having a side chain that is uncharged at physiological pH, but which has at least one bond in which the pair of electrons shared in common by two atoms is held more closely by one of the atoms. Genetically encoded polar amino acids include Cys (C) , Asn (N) , Gin (Q) Ser (S) and Thr (T) . "Hydrophobic Amino Acid" refers to an amino acid exhibiting a hydrophobicity of greater than zero according to the consensus hydrophobicity scale of Eisenberg, 1984, Ann. Rev. Biochem. 53:595-623. Genetically encoded hydrophobic amino acids include He (I) , Phe (F) , Val (V) , Leu (L) , Trp (W) , Met (M) , Ala (A) , Gly (G) and Tyr (Y) . "Aromatic Amino Acid" refers to a hydrophobic amino acid with a side chain having at least one aromatic or heteroaromatic ring. The aromatic or heteroaromatic ring may contain one or more substituents such as -OH, -SH, -CN, -F, -Cl, -Br, -I, -N0 2 , -NO, -NH 2 , -NHR, -NRR, -C(0)R, -C(0)OH, -C(0)OR, -C(0)NH 2 , -C(0)NHR, -C(0)NRR and the like where each R is independently (C^Cg) alkyl, substituted (C^C alkyl, (Ci-Cg) alkenyl, substituted (C^Cg) alkenyl, (C^C g ) alkynyl, substituted (C j -C alkynyl, (C 5 -C 20 ) aryl, substituted (C 5 -C 2C ) aryl, (C 6 -C 26 ) alkaryl, substituted (C 6 -C 26 ) alkaryl, 5-20 membered heteroaryl or substituted 5-20 membered heteroaryl. Genetically encoded aromatic amino acids include Phe (F) , Tyr (Y) and Trp (W) . "Nonpolar Amino Acid" refers to a hydrophobic amino acid having a side chain that is uncharged at physiological pH and which has bonds in which the pair of electrons shared in common by two atoms is generally held equally by each of the two atoms (i.e. , the side chain is not polar) . Genetically encoded apolar amino acids include Leu (L) , Val (V), He (I), Met (M) , Gly (G) and Ala (A). "Aliphatic Amino Acid" refers to a hydrophobic amino acid having an aliphatic hydrocarbon side chain. Genetically encoded aliphatic amino acids include Ala (A) , Val (V), Leu (L) and He (I). The amino acid residue Cys (C) is unusual in that it can form disulfide bridges with other Cys (C) residues or other sulfanyl-containing amino acids. The ability of Cys (C) residues (and other amino acids with -SH containing side chains) to exist in a peptide in either the reduced free -SH or oxidized disulfide-bridged form affects whether Cys (C) residues contribute net hydrophobic or hydrophilic character to a peptide. While Cys (C) exhibits a hydrophobicity of 0.04 according to the consensus scale of Eisenberg (Eisenberg, 1984, supra) , it is to be understood that for purposes of the present invention Cys (C) is categorized as a polar hydrophilic amino acid, notwithstanding the general classifications defined above. As will be appreciated by those of skill in the art, the above-defined categories are not mutually exclusive. Thus, amino acids having side chains exhibiting two or more physical-chemical properties can be included in multiple categories. For example, amino acid side chains having aromatic moieties that are further substituted with polar substituents, such as Tyr (Y) , may exhibit both aromatic hydrophobic properties and polar or hydrophilic properties, and can therefore be included in both the aromatic and polar categories. The appropriate categorization of any amino acid will be apparent to those of skill in the art, especially in light of the detailed disclosure provided herein. Certain amino acid residues, called "helix breaking" amino acids, have a propensity to disrupt the structure of α-helices when contained at internal positions of the helix. Amino acid residues exhibiting helix-breaking properties are well-known in the art (see, e.g.. Chou and Fasman, Ann. Rev. Biochem. 4 . 7:251-276) and include Pro (P) , D-Pro (p) and Gly (G) . While these amino acids conveniently fall into the categories defined above, with the exception of Gly (G) these residues should not be used to substitute amino acids at internal positions within the helix — they should only be used to substitute 1-3 amino acid residues at the N- ter inus and/or C-terminus of the peptide. The native structure of ApoA-I contains eight helical units that are thought to act in concert to bind lipids (Nakagawa et al., 1985, J. Am. Chem. Soc. 107:7087- 7092; Anantharamaiah et al., 1985, J. Biol. Chem. 260:10248- 10262; Vanloo et al., 1991, J. Lipid Res. 32:1253-1264; Mendez et al., 1994, J. Clin. Invest. 94:1698-1705; Palgunari et al., 1996, Arterioscler. Thromb. Vase. Biol. 16:328-338; Demoor et al., 1996, Eur. J. Biochem. 239:74-84). Thus, also included in the present invention are ApoA-I agonists comprised of dimers, trimers, tetramers and even higher order polymers ("multimers") of the core peptides described herein. Such multimers may be in the form of tandem repeats, branched networks or combinations thereof. The core peptides may be directly attached to one another or separated by one or more linkers. The core peptides that comprise the multimers may be the peptides of structure (I) , (II) or (III) analogues of structure (I) , (II) or (III) , mutated forms of structure (I) , (II) or (III) truncated or internally deleted forms of structure (I) , (II) or (III) extended forms of structure (I) , (II) or (III) and/or combinations thereof. The core peptides can be connected in a head-to-tail fashion (i.e., N-terminus to C-terminus), a head-to-head fashion, (i.e., N-terminus to N-terminus), a tail-to-tail fashion (i.e., C-terminus to C- terminus) , or combinations thereof. In one embodiment of the invention, the multimers are tandem repeats of two, three, four and up to about ten core peptides. Preferably, the multimers are tandem repeats of from 2 to 8 core peptides. Thus, in one embodiment, the ApoA-I agonists of the invention comprise multimers having the following structural formula: (IV) HHfLL m -HH n LL m -HH wherein: each m is independently an integer from 0 to 1, preferably 1; n is an integer from 0 to 10, preferably 0 to 8; each "HH" independently represents a core peptide or peptide analogue of structure (I) or a mutated, truncated, internally deleted or extended form thereof as described herein; each "LL" independently represents a linker, e.g. , Pro (P) , Gly (G) and Cys-Cys. In a preferred embodiment of the invention, the tandem repeats are internally punctuated by a single proline residue. To this end, in those instances where the core peptides are terminated at their N- or C-terminus with proline, such as, e.g., where X x in structure (I) is Pro (P) . In those instances where the core peptides do not contain an N- or C-terminal proline, LL is preferably Pro (P) . In certain embodiments of the invention, it may be desirable to employ cleavable linkers that permit the release of one or more helical segments (HH) under certain conditions. Suitable cleavable linkers include peptides having amino acid sequences that are recognized by proteases, oligonucleotides that are cleaved by endonucleases. Preferably, the cleavage conditions will be relatively mild so as not to denature or otherwise degrade the helical segments and/or non-cleaved linkers composing the multimeric ApoA-I agonists . Peptide and oligonucleotide linkers that can be selectively cleaved, as well as means for cleaving the linkers are well known and will be readily apparent to those of skill in the art. In a preferred embodiment, the linkers employed are peptides that are substrates for endogenous circulatory enzymes, thereby permitting the multimeric ApoA-I agonists to be selectively cleaved in vivo. Endogenous enzymes suitable for cleaving the linkers include, for example, proapolipoprotein A-I propeptidase. Appropriate enzymes, as well as peptide segments that act as substrates for such enzymes, are well-known in the art (see, e.g., Edelstein et al., 1983, J. Biol. Chem. 258:11430-11433; Zanis, 1983, Proc. Natl. Acad. Sci. USA 80:2574-2578). As discussed above, a key feature of the core peptides of the invention is their ability to form intermolecular hydrogen-bonds or salt bridges when arranged in an antiparallel fashion. Thus, in a preferred embodiment of the invention, linkers of sufficient length and flexibility are used so as to permit the helical segments (HH) of structure (II) to align in an antiparallel fashion and form intermolecular hydrogen-bonds or salt bridges in the presence of lipids. Linkers of sufficient length and flexibility include, but are not limited to, Pro (P) , Gly (G) , Cys-Cys. Alternatively, as the native apolipoproteins permit cooperative binding between antiparallel helical segments, peptide linkers which correspond in primary sequence to the peptide segments connecting adjacent helices of the native apolipoproteins, including, for example, ApoA-I, ApoA-II, ApoA-IV, ApoC-I, ApoC-II, ApoC-III, ApoD, ApoE and ApoJ can be conveniently used to link the core peptides. These sequences are well known in the art (see, e.g. , Rosseneu et al., "Analysis of the Primary and of the Secondary Structure of the Apolipoproteins," In: Structure and Function of Lipoproteins, Ch. 6, 159-183, CRC Press, Inc., 1992). Other linkers which permit the formation of intermolecular hydrogen bonds or salt bridges between tandem repeats of antiparallel helical segments include peptide reverse turns such as /3-turns and γ-turns. Generally, reverse turns are segments of peptide that reverse the direction of the polypeptide chain so as to allow a single polypeptide chain to adopt regions of antiparallel /3-sheet or antiparallel α-helical structure. /3-turns generally are composed of four amino acid residues and γ-turns are generally composed of three amino acid residues. The conformations and sequences of many peptide /3-turns have been well-described in the art and include, by way of example and not limitation, type-I, type-I', type-II, type-II', type-Ill, type-Ill', type-IV, type-V, type-V , type-VIa, type-VIb, type-VII and type-VIII (see, Richardson, 1981, Adv. Protein Chem. 34:167-339; Rose et al., 1985, Adv. Protein Chem. 37:1-109; Wilmot et al., 1988, J. Mol. Biol. 203:221-232; Sibanda et al., 1989, J. Mol. Biol. 206:759-777; Tramontano et al., 1989, Proteins: Struct. Funct. Genet. 6:382-394) . The specific conformations of short peptide turns such as /3-turns depend primarily on the positions of certain amino acid residues in the turn (usually Gly, Asn or Pro) . Generally, the type-I /3-turn is compatible with any amino acid residue at positions 1 through 4 of the turn, except that Pro cannot occur at position 3. Gly predominates at position 4 and Pro predominates at position 2 of both type-I and type-II turns. Asp, Asn, Ser and Cys residues frequently occur at position 1, where their side chains often hydrogen- bond to the NH of residue 3. In type-II turns, Gly and Asn occur most frequently at position 3, as they adopt the required backbone angles most easily. Ideally, type-I' turns have Gly at positions 2 and 3, and type-II' turns have Gly at position 2. Type-Ill turns generally can have most amino acid residues, but type- III' turns usually require Gly at positions 2 and 3. Type- Vla and VIb turns generally have a cis peptide bond and Pro as an internal residue. For a review of the different types and sequences of /3-turns in proteins and peptides the reader is referred to Wilmot et al., 1988, J. Mol. Biol. 203:221- 232. The conformation and sequences of many peptide γ- turns have also been well-described in the art (see, e.g. , Rose et al., 1985, Adv. Protein Chem. 37:1-109; Wilmer-White et al., 1987, Trends Biochem. Sci. 12:189-192; Wilmot et al. , 1988, J. Mol. Biol. 203:221-232; Sibanda et al., 1989, J. Mol. Biol. 206:759-777; Tramontano et al., 1989, Proteins: Struct. Funct. Genet. 6:382-394). All of these types of β- turns and γ-turn structures and their corresponding sequences, as well as later discovered peptide 3-turns and γ- turn structures and sequences, are specifically contemplated by the invention. While structure (I) , (II) and (III) contains 22 specified amino acid residue positions, it is to be understood that the core peptides of the invention can contain fewer than 22 amino acid residues. Indeed, truncated or internally deleted forms of structure (I) , (II) and (III) containing as few as 18 or even 15 amino acid residues that substantially retain the overall characteristics and properties of the amphipathic helix formed by the core peptides of structure (I) , (II) and (III) are considered to be within the scope of the present invention. Truncated forms of the peptides of structure (I) are obtained by deleting one or more amino acids from the N- and/or C-terminus of structure (I) , (II) and (III) . Internally deleted forms of structure (I) , (II) and (III) are obtained by deleting one or more amino acids from internal positions within the peptide of structure (I) , (II) and (III) . The internal amino acid residues deleted may or may not be consecutive residues. Those of skill in the art will recognize that deleting an internal amino acid residue from a core peptide of structure (I) , (II) and (III) will cause the plane of the hydrophilic-hydrophobic interface of the helix to rotate by 100° at the point of the deletion. As such rotations can significantly alter the amphipathic properties of the resultant helix, in a preferred embodiment of the invention amino acid residues are deleted so as to substantially retain the alignment of the plane of the hydrophilic-hydrophobic interface along the entire long axis of the helix. This can be conveniently achieved by deleting a sufficient number of consecutive or non-consecutive amino acid residues such that one complete helical turn is deleted. An idealized α-helix contains 3.6 residues per turn. Thus, in a preferred embodiment, groups of 3-4 consecutive or non- consecutive amino acid residues are deleted. Whether 3 amino acids or 4 amino acids are deleted will depend upon the position within the helix of the first residue to be deleted. Determining the appropriate number of consecutive or non- consecutive amino acid residues that constitute one complete helical turn from any particular starting point within an amphipathic helix is well within the capabilities of those of skill in the art. Due to the surmised importance of the basic cluster at the C-terminus of the core peptides of structure (I) , (II) and (III) in stabilizing the helix and the importance of the hydrophobic cluster in effecting lipid binding and LCAT activation, in preferred embodiments of the invention, residues comprising the basic and hydrophobic clusters are not deleted. Thus, in preferred embodiments, residues 19, 20 and 22 (basic cluster) and residues 3, 6, 9 and 10 (hydrophobic cluster) are not deleted. The core peptides of structure (I) , (II) and (III) can also be extended at one or both termini or internally with additional amino acid residues that do not substantially interfere with, and in some embodiments even enhance, the structural and/or functional properties of the peptides. Indeed, extended core peptides containing as many as 23, 25, 26, 29 or even more amino acid residues are considered to be within the scope of the present invention. Preferably, such extended peptides will substantially retain the net amphipathicity and other properties of the peptides of structure (I) , (II) and (III) . Of course, it will be recognized that adding amino acids internally will rotate the plane of the hydrophobic-hydrophilic interface at the point of the insertion in a manner similar to that described above for internal deletions. Thus, the considerations discussed above in connection with internal deletions apply to internal additions, as well. In one embodiment, the core peptides are extended at the N- and/or C-terminus by least one helical turn. Preferably, such extensions will stabilize the helical secondary structure in the presence of lipids, such as the end-cap amino acids and segments previously described. In a particularly preferred embodiment, the core peptide of structure (I) , (II) and (III) is extended at the C-terminus by a single basic amino acid residue, preferably Lys (K) . 5.1.3. PREFERRED EMBODIMENTS The ApoA-I agonists encoded by the nucleotide sequences of the present invention can be further defined by way of preferred embodiments. In one preferred embodiment, the nucleotide sequences of the invention encode ApoA-I agonists composed of core peptides of structure (I) containing 22 amino acid residues in which: X x is Pro (P) , Gly (G) or Ala (A) ; X 2 is Val (V) or Leu (L) ; X 3 is Leu (L) ; X 4 is Asp (D) or Glu (E) ; X 5 is Leu (L) or Phe (F) ; X 6 is Leu (L) or Phe (F) ; X 7 is Lys (K) or Arg (R) ; X 8 is Glu (E) ; X 9 is Leu (L) ; X 10 is Leu (L) or Trp (W) ; X X1 is Asn (N) or Gin (Q) ; X 12 is Glu (E) ; X 13 is Leu (L) ; X 14 is Leu (L) or Trp (W) ; X 15 is Glu (E) ; X 16 is Ala (A) or Trp (W) ; X 17 is Leu (L) ; one of X 18 or X 19 is Gin (Q) and the other is Lys (K) ; X 20 is Lys (K) ; X 21 is Leu (L) ; and X 22 is Lys (K) . In yet another preferred embodiment, the nucleotide sequences of the present invention encode ApoA-I agonists composed of core peptides of structure (I) containing 22 amino acid residues in which: X λ is Pro (P) , Gly (G) or Ala (A) ; X 2 is Val (V) ; X 3 is Leu (L) ; X 4 is Asp (D) or Glu (E) ; X 5 is Leu (L) or Phe (F) ; X 6 is Phe (F) X 7 is Arg (R) X 8 is Glu (E) X 9 is Leu (L) X 12 is Glu (E) ; X 14 is Leu ( ) , X 19 is Gin (Q) X 2 o is Lys ( ) X 22 is Lys ( ) . Particularly preferred nucleotide sequences according to this aspect of the invention are those that encode core peptides selected from the group consisting of: peptide 3 PVLDLFRELLNEGLEALKQKLK (SEQ ID NO: 3); peptide 13 GVLDLFRELLNEGLEALKQKLK (SEQ ID NO: 13); peptide 138 PVLDLFRELLNEGLEWLKQKLK (SEQ ID NO: 138); peptide 139 PVLDLFRELWNEGLEALKQKLK (SEQ ID NO: 139); peptide 141 PVLDFFRELLNEGLEALKQKLK (SEQ ID NO: 141); peptide 142 PVLELFRELLNEGLEALKQKLK (SEQ ID NO: 142). In still another preferred embodiment, the nucleotide sequences encode ApoA-I agonists which are 22- amino acid residue peptides according to structure (I) , in which X 9 is Gly (G) and each of X 10 , X 13 , χ 14 , χ 16 and X 17 is other than Gly (G) . A particularly preferred ApoA-I agonist according to this aspect of the invention is peptide 20: PVLDLFREGLNELLEALKQKLK (SEQ ID NO: 20) . In still another preferred embodiment, the nucleotide sequences encode ApoA-I agonists which are 22- amino acid residue peptides according to structure (I) , in which X 10 is Gly (G) and each of X 9 , X 13 , X 14 , X 16 and X 17 is other than Gly (G) . A particularly preferred ApoA-I agonist according to this aspect of the invention is peptide 9 : PVLDLFRELGNELLEALKQKLK (SEQ ID NO: 9) . In still another preferred embodiment, the nucleotide sequences encode ApoA-I agonists which are 22- amino acid residue peptides according to structure (I) , in which X 14 is Gly (G) and each of X 9 , X 10 , X 13 , X 16 and X 17 is other than Gly (G) . A particularly preferred ApoA-I agonist according to this aspect of the invention is peptide 126: PVLDLFRELLNELGEALKQKLK (SEQ ID NO: 26) . In still another preferred embodiment, the nucleotide sequences are ApoA-I agonists which are 22-amino acid residue peptides according to structure (I) , in which X 16 is Gly (G) and each of X 9 , X 10 , X 13 , X 14 and X 17 is other than Gly (G) . A particularly preferred ApoA-I agonist according to this aspect of the invention is peptide 22: PVLDLFRELLNELLEGLKQKLK (SEQ ID NO: 22) . In still another preferred embodiment, the nucleotide sequences are ApoA-I agonists which are 22-amino acid residue peptides according to structure (I) , in which X 17 is Gly (G) and each of X 9 , X 10 , X 13 , X 14 and X 16 is other than Gly (G) . A particularly preferred ApoA-I agonist according to this aspect of the invention is peptide 12 : PVLDLFRELLNELLEAGKQKLK (SEQ ID NO: 12). In yet another preferred embodiment, the nucleotide sequences are ApoA-I agonists which are 22-amino acid residue peptides according to structure (I) , in which each of X 9 , X 10 , X 13 , X 14 , X 1€ and X :7 is other than Gly (G) . Agonists are 22-amino acid residue peptides according to structure (I) , in which: X j. is Pro (P) , Gly (G) , Ala (A) ; X 2 is Val (V) or Leu (L) ; X 3 is Leu (L) ; X 4 is Asp (D) or Glu (E) ; X 5 is Leu (L) or Phe (F) ; X 6 is Leu (L) or Phe (F) ; X 7 is Arg (R) or Lys (K) ; X 8 is Glu (E) ; X 9 is Leu (L) ; X 10 is Leu (L) or Trp (W) ; X X1 is Asn (N) or Gin (Q) ; X 12 is Glu (E) ; X 13 is Leu (L) ; X 14 is Leu (L) or Trp (W) ; X 15 is Glu (E) ; X 16 is Ala (A) , Leu (L) or Trp (W) ; X 17 is Leu (L) ; one of X 18 or X 19 is Gin (Q) and the other is Lys ( ); X 20 is Lys (K) ; X 21 is Leu (L) ; and X 22 is Lys (K) . In a particularly preferred embodiment according to this aspect of the invention, X 2 is Val (V) ; X 4 is Asp (D) ; X 5 is Leu (L) ; X 6 is Phe (F) ; X 7 is Arg R) ; X 10 is Leu (L) ; X xl is Asn (N) ; X 13 is Leu (L) ; X 14 is Leu (L) ; X 16 is Ala (A) ; X 17 is 5 Leu (L) ; X 18 is Lys (K) ; X 19 is Gin (Q) ; X 20 is Lys (K) and/or X 22 is Lys (K) . In still another preferred embodiment, the nucleotide sequences encode ApoA-I agonists which are altered or mutated forms of the peptides of structure (I) in which: 0 X- L is other than Val (V) or Leu (L) ; X 5 is other than Lys (K) , Glu (E) or Trp (W) ; X 6 is other than Trp (W) ; X 7 is other than Trp (W) or Leu (L) ; X 8 is other than Trp (W) ; 5 X 9 is other than Lys (K) or Trp (W) ; X X1 is other than Trp (W) ; X 12 is other than " Trp (W) or Leu (L) ; X 13 is other than Glu (E) or Trp (W) ; X 15 is other than Trp (W) ; and/or 0 X 21 is other than Lys (K) . In yet another preferred embodiment, the nucleotide sequences of the invention encode ApoA-I agonists which are selected from the group of peptides set forth below: 5 peptide 2 GVLDLFRELLNELLEALKQKLKK (SEQ ID NO: 2); peptide 3 PVLDLFRELLNELLEWLKQKLK (SEQ ID NO: 3); peptide 4 PVLDLFRELLNELLEALKQKLK (SEQ ID NO: 4); peptide 7 PVLDLFKELLNELLEALKQKLK (SEQ ID NO:7); peptide 8 PVLDLFRELLNEGLEALKQKLK (SEQ ID NO: 7); 0 peptide 9 PVLDLFRELGNELLEALKQKLK (SEQ ID NO: 8); peptide 11 PVLDLFKELLQELLEALKQKLK (SEQ ID NO: 9); peptide 12 PVLDLFRELLNELLEAGKQKLK (SEQ ID NO: 10); peptide 13 GVLDLFRELLNEGLEALKQKLK (SEQ ID NO:ll); • _Jo c peptide 15 PVLDLFRELWNELLEALKQKLK (SEQ ID NO: 12); peptide 16 PVLDLLRELLNELLEALKQKLK (SEQ ID NO: 13); peptide 17 PVLELFKELLQELLEALKQKLK (SEQ ID NO: 14); peptide 18 GVLDLFRELLNELLEALKQKLK (SEQ ID NO: 15) peptide 20 PVLDLFREGLNELLEALKQKLK (SEQ ID NO: 16) peptide 22 PVLDLFRELLNELLEGLKQKLK (SEQ ID NO: 17) peptide 23 PLLELFKELLQELLEALKQKLK (SEQ ID NO: 18) peptide 24 PVLDLFRELLNELLEALQKKLK (SEQ ID NO: 19) peptide 26 PVLDLFRELLNELLELLKQKLK (SEQ ID NO:21) peptide 28 PVLDLFRELLNELWEALKQKLK (SEQ ID NO:23) peptide 29 AVLDLFRELLNELLEALKQKLK (SEQ ID NO:24) peptide 123 QVLDLFRELLNELLEALKQKLK (SEQ ID NO: 123 peptide 125 NVLDLFRELLNELLEALKQKLK (SEQ ID NO: 124 peptide 126 PVLDLFRELLNELGEALKQKLK (SEQ ID NO: 125 peptide 127 PVLDLFRELLNELLELLKQKLK (SEQ ID NO: 126 peptide 128 PVLDLFRELLNELLEFLKQKLK (SEQ ID NO: 127 peptide 129 PVLELFNDLLRELLEALQKKLK (SEQ ID NO: 128 peptide 130 PVLELFNDLLRELLEALKQKLK (SEQ ID NO: 129 peptide 131 PVLELFKELLNELLDALRQKLK (SEQ ID NO: 130 peptide 132 PVLDLFRELLENLLEALQKKLK (SEQ ID NO:131 peptide 133 PVLELFERLLEDLLQALNKKLK (SEQ ID NO: 132 peptide 134 PVLELFERLLEDLLKALNQKLK (SEQ ID NO: 133 peptide 135 DVLDLFRELLNELLEALKQKLK (SEQ ID NO: 134 peptide 136 PALELFKDLLQELLEALKQKLK (SEQ ID NO: 135 peptide 138 PVLDLFRELLNEGLEWLKQKLK (SEQ ID NO:136 peptide 139 PVLDLFRELWNEGLEALKQKLK (SEQ ID NO: 137 peptide 141 PVLDFFRELLNEGLEALKQKLK (SEQ ID NO: 138 peptide 142 PVLELFRELLNEGLEALKQKLK (SEQ ID NO: 139 In preferred embodiment, the nucleotide sequences encode ApoA-I agonists which are 22 amino acid residue peptides according to structure (II) , in which: X x is Pro (P) , Gly (G) , Ala (A) or Asn (N) ; X 2 is Ala (A) , Val (V) or Leu (L) ; X 5 is Leu (L) ; X 6 is Phe (F) ; X X1 is Glu (E) ; X 19 is Lys (K) ; X 20 is Lys (K) ; and/or X 22 is Lys (K) , and each of X 3 , X 4 , X 7 , X 8 , x 9 , X 10 , χ 12 , X 13 , X 14 , X 15 , X 16 , X 17 , X 18 and X 21 are as previously defined for structure (II) . Particularly preferred ApoA-I agonists according to this aspect of the invention are those in which X 2 is Val (V) ; and/or X 18 is Gin (Q) . In still another preferred embodiment, the ApoA-I agonists are 22 amino acid residue peptides according to structure (II) , in which one of X 10 , X 13 or X 14 is Gly (G) and the others of X 10 , X 13 and X 14 are other than Gly (G) . When X 14 is Gly (G) , X 7 is preferably Glu (E) . Particularly preferred nucleotide sequences according to this aspect of the invention encode ApoA-I agonists which are peptides selected from the group consisting of: peptide 148: PVLELFENLLERLGDALQKKLK (SEQ ID NO: 148); peptide 151: PVLELFENLGERLLDALQKKLK (SEQ ID NO: 151); peptide 154: PVLELFENLLERGLDALQKKLK (SEQ ID NO: 154). In still another preferred embodiment, the ApoA-I agonists are 22-amino acid residue peptides according to structure (II) , in which each of X 10 , X 13 and X 14 is other than Gly (G). In still another preferred embodiment, the nucleotide sequences encode ApoA-I agonists which are altered or mutated forms of the peptides according to structure (II) , in which: X 4 is other than Asp (D) ; X 5 is other than Phe (F) ; X 6 is other than Trp (W) ; X 7 is other than Leu (L) or Asp (D) ; X 9 is other than Gly (G) or Trp (W) ; X 12 is other than Lys (K) ; X 13 is other than Trp (W) ; X 14 is other than Trp (W) ; X 15 is other than Glu (E) ; X 16 is other than Trp (W) or Leu (L) ; and/or X 17 is other than Trp (W) . In still another preferred embodiment, the ApoA-I agonists are 22 amino acid residue peptides according to structure (II) , in which when X 7 is Leu (L) , X 10 is Trp (W) , X λ is other than Gly (G) and/or X 14 is other than Gly (G) . A particularly preferred peptide according to this aspect of the invention is peptide 155 (PVLELFLNLWERLLDALQKKLK; SEQ ID NO: 155). In still another preferred embodiment, the nucleotide sequences encode ApoA-I agonists which are selected from the group of peptides set forth below: peptide 145: GVLELFENLLERLLDALQKKLK (SEQ ID NO: 145) peptide 146: PVLELFENLLERLLDALQKKLK (SEQ ID NO: 146) peptide 147: PVLELFENLLERLFDALQKKLK (SEQ ID NO: 147) peptide 148: PVLELFENLLERLGDALQKKLK (SEQ ID NO: 148) peptide 149: PVLELFENLWERLLDALQKKLK (SEQ ID NO: 149) peptide 150: PLLELFENLLERLLDALQKKLK (SEQ ID NO: 150) peptide 151: PVLELFENLGERLLDALQKKLK (SEQ ID NO: 151) peptide 152: PVFELFENLLERLLDALQKKLK (SEQ ID NO: 152) peptide 153: AVLELFENLLERLLDALQKKLK (SEQ ID NO: 153) peptide 154: PVLELFENLLERGLDALQKKLK (SEQ ID NO: 154) peptide 155: PVLELFLNLWERLLDALQKKLK (SEQ ID NO: 155) peptide 186: PVLELFEQLLERLLDALQKKLK (SEQ ID NO: 186) peptide 187: PVLELFENLLERLLDALNKKLK (SEQ ID NO: 187) peptide 188: PVLELFENLLDRLLDALQKKLK (SEQ ID NO: 188) peptide 189: DVLELFENLLERLLDALQKKLK (SEQ ID NO: 189) In one preferred embodiment, the ApoA-I agonists are 18 amino acid residue peptides according to structure (III). In another preferred embodiment, the nucleotide sequences encode ApoA-I agonists which are 18 amino acid residue peptides according to structure (III) in which: X 2 is Ala (A) , Val (V) or Leu (L) ; X 4 is Asp (D) or Glu (E) ; X 7 is Arg (R) or Lys (K) ; X 8 is Asp (D) or Glu (E) ; X X1 is Glu (E) or Asn (N) ; X 12 is Glu (E) ; X 14 is Arg (R) , Lys (K) or Leu (L) ; X 16 is Arg (R) or Lys (K) ; and/or X 18 is Arg (R) or Lys (K) and X 17 X 3 , X 5 , X 6 , X 9 , X 10 , X 13 , X 15 and X 17 are as previously defined for structure (III) . In another preferred embodiment, the ApoA-I agonists are 18 amino acid residue peptides according to structure (III) , in which when X u is Asn (N) , X 14 is Leu (L) and when X l is other than Asn (N) , X 14 is other than Leu (L) An exemplary particularly preferred embodiment according to this aspect of the invention is the peptide 209 (PVLDLFRELLNELLQKLK; SEQ ID NO: 209). In still another preferred embodiment, the ApoA-I agonists are altered or mutated forms of the peptides according to structure (III) , in which X x is other than Asp (D) ; X 9 is other than Gly (G) ; X 10 is other than Gly (G) ; X 12 is other than Leu (L) ; and X 13 is other than Gly (G) . In still another preferred embodiment, the nucleotide sequences encode ApoA-I agonists which are selected from the group of peptides set forth below: peptide 191 PVLDLLRELLEELKQKLK* (SEQ ID NO: 191) peptide 192 PVLDLFKELLEELKQKLK* (SEQ ID NO: 192) peptide 193 PVLDLFRELLEELKQKLK* (SEQ ID NO: 193) peptide 194 PVLELFRELLEELKQKLK* (SEQ ID NO: 194) peptide 195 PVLELFKELLEELKQKLK* (SEQ ID NO: 195) peptide 196 PVLDLFRELLEELKNKLK* (SEQ ID NO: 196) peptide 197 PLLDLFRELLEELKQKLK* (SEQ ID NO: 197) peptide 198 GVLDLFRELLEELKQKLK* (SEQ ID NO: 198) peptide 199 PVLDLFRELWEELKQKLK* (SEQ ID NO: 199) peptide 200 NVLDLFRELLEELKQKLK* (SEQ ID NO: 200) peptide 201 PLLDLFKELLEELKQKLK* (SEQ ID NO: 201) peptide 202 PALELFKDLLEELRQKLR* (SEQ ID NO: 202) peptide 203 AVLDLFRELLEELKQKLK* (SEQ ID NO: 203) peptide 204 PVLDFFRELLEELKQKLK* (SEQ ID NO: 204) peptide 205 PVLDLFREWLEELKQKLK* (SEQ ID NO: 205) peptide 206 PLLELLKELLEELKQKLK* (SEQ ID NO: 206) peptide 207 PVLELLKELLEELKQKLK* (SEQ ID NO: 207) peptide 208 PALELFKDLLEELRQRLK* (SEQ ID NO: 208) peptide 209 PVLDLFRELLNELLQKLK (SEQ ID NO: 209) peptide 210 PVLDLFRELLEELKQKLK (SEQ ID NO: 210) peptide 213 PALELFKDLLEEFRQRLK* (SEQ ID NO: 213) peptide 215 PVLDLFRELLEEWKQKLK* (SEQ ID NO: 215) peptide 229 PVLELFERLLEDLQKKLK (SEQ ID NO: 229) peptide 230 PVLDLFRELLEKLEQKLK (SEQ ID NO: 230) peptide 231 PLLELFKELLEELKQKLK* (SEQ ID NO: 231) In yet another preferred embodiment, the nucleotide sequences of the present invention encode ApoA-I agonists which are multimeric forms according to structure IV in which each HH is independently a peptide according to structure (I) , (II) or (III) , or any of the preferred peptides according to structure (I) , (II) or (III) described herein. In a final preferred embodiment, the ApoA-I agonists are not any of the peptides listed in Table VIII which are composed of amino acids not genetically encoded or which exhibit an LCAT activation activity of less than 38% as compared with native human ApoA-I. 5.1.4. ANALYSIS OF STRUCTURE AND FUNCTION The structure and function of the core peptides or peptide analogues of the invention, as well as ApoA-I agonists composed of such core peptides, including the multimeric forms described above, can be assayed in order to select active agonists or mimetics of ApoA-I. For example, the core peptides or peptide analogues can be assayed for their ability to form α-helices in the presence of lipids, to bind lipids, to form complexes with lipids, to activate LCAT, to promote cholesterol efflux, etc. Methods and assays for analyzing the structure and/or function of the peptides are well-known in the art. Preferred methods are provided in the working examples, infra. For example, the circular dichroism (CD) and nuclear magnetic resonance (NMR) assays described in Section 7, infra, can be used to analyze the structure of the peptides or peptide analogues — particularly the degree of helicity in the presence of lipids. The ability to bind lipids can be determined using the fluorescence spectroscopy assay described in Section 7, infra. The ability of the peptides and/or peptide analogues to activate LCAT can be readily determined using the LCAT activation described in Section 8 , infra. The in vitro and in vivo assays described in Section 9 and 10, infra, can be used to evaluate the half-life, distribution, cholesterol efflux and effects on RCT. Generally, core peptides and/or peptide analogues according to the invention which exhibit the properties listed in TABLE VI, infra, are considered to be active. TABLE VI PROPERTIES OF ACTIVE PEPTIDES PROPERTY RANGE PREFERRED RANGE % Helicity in the presence of > 60' > 80 lipids (Ri=30) (unblocked 22- amino acid residue peptides) % Helicity in the presence of > 40% > 603 lipids (Ri=30) (unblocked 18- amino acid residue peptides) % Helicity in the presence of > 60? > 805 lipids (Ri=30) (blocked 18-amino acid residue peptides and shorter peptides) Lipid Binding (in the presence of 0.5 - lOμM SUVs) peptide LCAT activation > 38% > 80% Ri is lipid:peptide molar ratio. As illustrated in the working examples, infra, core peptides which exhibit a high degree of LCAT activation (> 38%) generally possess significant α-helical structure in the presence of lipidic small unilamellar vesicles (SUVs) (> 60% helical structure in the case of unblocked peptides containing 22 or more amino acid residues and blocked peptides containing 18 or fewer amino acid residues; > 40% helical structure in the case of unblocked peptides containing 18 or fewer amino acids) , and those peptides which exhibit little or no LCAT activation possess little α-helical structure. However, in certain instances, peptides which exhibit significant helical structure in the presence of lipids do not effect significant LCAT. Similarly, while core peptides that exhibit significant LCAT activation typically bind lipids, in certain instances peptides which exhibit lipid binding do not effect significant LCAT activation. As a consequence, it will be recognized by those of skill in the art that while the ability of the core peptides described herein to form α-helices (in the presence of lipids) and to bind lipids is critical for activity, in many instances these properties may not be sufficient. Thus, in a preferred embodiment core peptides of the invention are subjected to a series of screens to select for core peptides exhibiting significant pharmacological activity. In a first step, a core peptide is screened for its ability to form an α-helix in the presence of lipids using the CD assay described in Section 7, infra. Those peptides which are at least 40% helical or 60% helical in the presence of lipids (at a cone, of about 5 μM and a lipid:peptide molar ratio of about 30) are then screened for their ability to bind lipids using the fluorescence assay described in Section 1 i infra. Of course, only those core peptides which contain . . . . . a fluorescent Trp (W) residue are screened for lipid binding via fluorescence. However, for peptides which do not contain fluorescent residues, binding to lipids is obvious when helicity increases in the presence of lipids. Core peptides which exhibit lipid binding in the presence of SUVs (0.5-10 μM peptide; lipid: peptide molar ratio in the range of 1 to 50) are then screened for pharmacological activity. Of course, the pharmacological activity screened for will depend upon the desired use of the ApoA-I agonists. In a preferred embodiment, the core peptides are screened for their ability to activate LCAT, as peptides which activate LCAT are particularly useful in the methods described herein. Core peptides which exhibit at least about 38% LCAT activation as compared with native human ApoA-I (as determined using the LCAT activation assay described in Section 8, infra), are preferred, with core peptides exhibiting 50%, 60%, 70%, 80% or even 90% or more being particularly preferred. 5.2. DNA VECTORS AND CASSETTES ENCODING ApoA-1 In accordance with the present invention the nucleotide sequences encoding native ApoA-I, modified forms of ApoA-I or peptides with ApoA-I activity, including ApoA-I agonists and superagonists, are inserted into a cassette or an appropriate expression vehicle, i.e., a vector which contains the necessary elements for the transcription and translation of the inserted coding sequence, or in the case of an RNA viral vector, the necessary elements for replication and translation. The nucleotide sequences of the present invention may be administered as "naked" DNA constructs for both ex vivo and jLn vivo gene therapy protocols. Naked DNA plas ids encoding the ApoA-I peptides and agonists may be injected into a subject and successfully taken up by cells and expressed as peptides (Feigner et al. U.S. Patent No. 5,580,859, incorporated herein by reference in its entirety) . "Naked" DNA may also be administered in complexes with nonlipid cationic polymers or in complexes with liposomes to enhance cellular uptake. In another embodiment of the present invention the expression vehicle is transfected into a suitable target cell which will express the peptide. Depending on the expression system used, the expressed peptide is then isolated by procedures well-established in the art. Methods for recombinant protein and peptide production are well known in the art (see, e.g., Maniatis et al., 1989, Molecular Cloning A Laboratory Manual, Cold Spring Harbor Laboratory, N.Y.; and Ausubel et al., 1989, Current Protocols in Molecular Biology, Greene Publishing Associates and Wiley Interscience, N.Y.). In accordance with the present invention, the DNA cassettes contain nucleotide sequences encoding the preproform and the proform of ApoA-I to ensure that the ApoA- I peptides are correctly processed and secreted from the host cell. The preproform of ApoA-I contains an 18aa leader or signal sequence at the amino terminus cleaved upon secretion of the ProApoA-I from the host cell. The leader sequence of ApoA-I is of the standard length and hydrophobicity (see, Davis et al. 1980 Nature 283:433-438) and ends in an amino acid with a small side chain, e.g. , alanine. By way of example and not by limitation, the following leader sequences may be incorporated into the DNA cassettes and vectors of the present invention: 5'MKAAVLTLAVLFLTGSQA3 ' (SEQ ID NO: ) or 5'MKAAVLAVALVFLTGCQA3' (SEQ ID NO: ). Any sequence which results in the secretion of the peptide from the host cell may be used in accordance with the present invention. The proform of ApoA-I, ProApoA-I contains a six- amino acid amino-terminal extension with the sequence: R-H-F- W-Q-Q (SEQ ID NO: ) or X-E-F-X-Q-Q. (SEQ ID NO: ). The extracellular cleavage of the prosegment by a specific protease generates the plasma form of ApoA-I. In accordance with the present invention, the sequences encoding the six- amino acid extension may be incorporated into the DNA cassettes and vectors of the invention to ensure that the encoded ApoA-I peptides are correctly processed once they are secreted from the host cell. To increase efficiency of production, the polynucleotide can be designed to encode multiple units of the peptide separated by enzymatic cleavage sites — either homopolymers (repeating peptide units) or heteropoly ers (different peptides strung together) can be engineered in this way. The resulting polypeptide can be cleaved (e.g. , by treatment with the appropriate enzyme) in order to recover the peptide units. This can increase the yield of peptides driven by a single promoter. In a preferred embodiment, a polycistronic polynucleotide can be designed so that a single mRNA is transcribed which encodes multiple peptides (i.e. , homopolymers or heteropolymers) each coding region operatively linked to a cap-independent translation control sequence; e.g. , an internal ribosome entry site (IRES) , such as the sequences described by Pelletier et al. 1988 Nature 334:320-325. In a preferred embodiment, the IRES is derived from the 5' noncoding region of the human immunoglobulin heavy-chain-binding protein (BiP) mRNA (Macejak et al. 1991 Nature 353: 90-94). Preferably, the IRES region is derived from a picornavirus IRES region sequence; the IRES sequence is selected from the group consisting of an enterovirus, rhinovirus, cardiovirus, and aphthovirus IRES sequence; a hepatitis A virus IRES sequence, a hepatitis B virus sequence and a hepatitis C virus IRES sequence. When used in appropriate viral expression systems, the translation of each peptide encoded by the mRNA is directed internally in the transcript; e.g. , by the IRES. Thus, the polycistronic construct directs the transcription of a single, large polycistronic mRNA which, in turn, directs the translation of multiple, individual peptides. This approach eliminates the production and enzymatic processing of polyproteins and may significantly increase yield of peptide driven by a single promoter . A variety of host-expression vector systems may be utilized to express the peptides described herein. Any host- expression system may be used in accordance with the present invention that the system (1) expresses the ApoA-I peptides of the invention; (2) utilizes expression control elements (e.g. , promoters and enhancers) that are operable in mammalian cells; and (3) expresses the ApoA-I nucleotide sequences at high copy numbers. In a preferred embodiment, any expression system which result in an increased copy number of the nucleotide sequences encoding ApoA-I peptides and agonists in human cells when engineered using ex vivo or in vivo gene therapy protocols. These include, but are not limited to, microorganisms such as bacteria transformed with recombinant bacteriophage DNA or plasmid DNA expression vectors containing an appropriate coding sequence; yeast or filamentous fungi transformed with recombinant yeast or fungi expression vectors containing an appropriate coding sequence; insect cell systems infected with recombinant virus expres- sion vectors (e.g., baculovirus) containing an appropriate coding sequence; plant cell systems infected with recombinant virus expression vectors (e.g., cauliflower mosaic virus or tobacco mosaic virus) or transformed with recombinant plasmid expression vectors (e.g., Ti plasmid) containing an appropriate coding sequence; or animal cell systems. The expression elements of the expression systems vary in their strength and specificities. Depending on the host/vector system utilized, any of a number of transcription and translation elements operable in mammalian, preferably human, host cell systems, including constitutive and inducible promoters, may be used in the expression vector. In a preferred embodiment, the expression elements incorporated into the vectors and cassettes of the present invention are the σis- and trans- regulatory elements which regulate expression of the native ApoA-I gene. In particular, transcriptional regulatory and enhancer elements are found in the nucleotide sequences located -222 to -110 upstream of the ApoA-I gene. For example, the binding site for ApoA-I regulatory protein-1 (ARP-1) a member of the steroid hormone receptor superfamily is within the liver- specific transcriptional enhancer, located -222 to -110 DNA region upstream of the ApoA-I gene. The consensus sequence for ARP-1 binding is 5 'TGAACCCTTGACCCCT3 ' (SEQ ID NO: ) (see, Ladias et al. 1991 Science 251:561-565) . Additional ApoA-I transcriptional regulation sequences and enhancer elements are disclosed in Sorci-Thomas et al. 1991 Journal of Biol. Chem. 266:18045-18050, Dai et al. 1990 Eur. J. Biochem. 190:305-310, Rottman et al. 1991 Molecular and Cell Biology 11:3814-3820. When cloning in bacterial, plant, insect or mammalian cell systems, promoters derived from the genome of mammalian cells (e.g., metallothionein promoter) or from mammalian viruses (e.g., the adenovirus late promoter; the vaccinia virus 7.5 K promoter) may be used; when generating cell lines that contain multiple copies of expression product, SV40-, BPV- and EBV-based vectors may be used with an appropriate selectable marker. In mammalian host cells, a number of viral-based expression systems may be utilized. In cases where an adenovirus is used as an expression vector, the ApoA-I peptide coding sequence of interest may be ligated to an adenovirus transcription/translation control complex, e.g., the late promoter and tripartite leader sequence. This chimeric gene may then be inserted in the adenovirus genome by in vitro or in vivo recombination. Insertion in a non- essential region of the viral genome (e.g., region El or E3) will result in a recombinant virus that is viable and capable of expressing an ApoA-I peptide in infected hosts. (e.g., See Logan and Shenk, 1984, Proc. Natl. Acad. Sci. USA 81, 3655-3659) . Specific initiation signals may also be required for efficient translation of inserted ApoA-I peptide coding sequences. These signals include the ATG initiation codon and adjacent sequences. In cases where an entire ApoA-I, including its own initiation codon and adjacent sequences, is inserted into the appropriate expression vector, no additional translational control signals may be needed. However, in cases where only a portion of the ApoA-I peptide coding sequence is inserted, exogenous translational control signals, including, perhaps, the ATG initiation codon, must be provided. Furthermore, the initiation codon must be in phase with the reading frame of the desired coding sequence to ensure translation of the entire insert. These exogenous translational control signals and initiation codons can be of a variety of origins, both natural and synthetic. The efficiency of expression may be enhanced by the inclusion of appropriate transcription enhancer elements, transcription terminators, etc. (see Bittner, et al . , 1987, Methods in Enzymol. 153, 516-544). Other expression systems for producing the peptides of the invention will be apparent to those having skill in the art. 5.2.1. VIRAL VECTORS ENCODING APOA-I In accordance with the present invention, the nucleotide sequences and DNA cassettes described above encoding ApoA-I agonists or peptides with ApoA-I activity may be engineered into appropriate viral vectors. The viral vectors described herein are particularly useful for ijn vivo genetic approaches to supply the nucleotide sequences of the present invention. In accordance with the present invention, the viral vectors engineered to express native ApoA-I are not encompassed by the present invention. For the practice of the present invention, viruses which display a suitable tropism for disease target cells, e.g.. liver cells, cells of large and small intestine, endothelial cells, etc., or which are genetically engineered to display a suitable tropism for the target cells, are genetically engineered to contain nucleotide sequences that encode ApoA-I agonist peptides. For the practice of the present invention, viruses which display a tropism for liver cells and cells of the small and large intestine are a particularly preferred embodiment of the present invention. Viral vectors which can be used in accordance with the invention include, but are not limited to hepadnavirus, adenovirus, adeno-associated virus, herpes virus, retrovirus, parvovirus, vaccinia virus, etc. In a specific embodiment, attenuated viruses, such as hepadnaviruses, which have a natural tropism for hepatocytes, may be engineered and used for gene therapy in accordance with the present invention. Hepadnaviruses may be engineered to deliver the nucleotide sequences encoding native ApoA-I and ApoA-I to the cells and organs where it is naturally expressed. There are regions of the hepadnavirus genome which can serve as regions to insert foreign DNA sequences. In particular, sequences encoding the hepatitis B virus (HBV) surface antigen proteins, pre-Sl and pre-S2 , can be targeted for the insertion of DNA sequences encoding ApoA- I peptides and agonists. For example, nucleotide sequences encoding the ApoA-I peptides may be insert downstream of the TATA-like sequence (at position 278) which is the promoter for the pre-Sl mRNA or may be inserted downstream of the SV40 like promoter (at position 3166) which is the promoter for the pre-S2 mRNA. The insertion of foreign coding sequences downstream of these regions places them under the regulation of viral gene expression without disruption of other essential viral activities. Adenoviruses are other viral vectors that can be used in gene therapy. Adenoviruses are especially attractive vehicles for delivering genes to liver and respiratory epithelia. Adenoviruses naturally infect respiratory epithelia where they cause a mild disease. Other targets for adenovirus-based delivery systems are liver, the central nervous system, endothelial cells, and muscle. Adenoviruses have the advantage of being capable of infecting non-dividing cells. Kozarsky and Wilson, 1993, Current Opinion in Genetics and Development 3:499-503 present a review of adenovirus-based gene therapy. In addition, Gerard et al., 1996, Current Opin. in Lipidology 7:105-111 describes adenovirus-mediated gene transfer as a means of delivering ApoA-I. Bout et al., 1994, Human Gene Therapy 5:3-10 demonstrated the use of adenovirus vectors to transfer genes to the respiratory epithelia of rhesus monkeys. Other instances of the use of adenoviruses in gene therapy can be found in Rosenfeld et al., 1991, Science 252:431-434; Rosenfeld et al., 1992, Cell 68:143-155; and Mastrangeli et al., 1993, J. Clin. Invest, 91:225-234. Adeno-associated virus (AAV) has also been proposed for use in gene therapy (Walsh et al., 1993, Proc. Soc. Exp. Biol. Med. 204:289-300. For example, the cassettes encoding heteropolymers of ApoA-I peptides (i.e. , heteropolymers containing ApoA-I agonists and superagonists separated by enzyme cleavage sites or by IRES sequences) may be advantageously engineered into adenoviruses. Gene sequences required for regulating adenoviral gene expression which can be manipulated in accordance with the invention include region El, region E3 , or between the right ITR and region E4. These regions may be replaced with the TRE of interest and incorporated into viral particles by packaging of the recombinant adenoviral genome. There are three regions of adenovirus which would be preferred sites for the insertion of foreign DNA sequences for the purpose of engineering recombinant viruses. These regions include (a) the EIA region and the major late promoter (MLP) ; (2) the MLP, together with the tripartite leader; and (3) the replacement of the E3 region. The E3 region has been shown to be dispensable for viral packaging in tissue culture. Chimeric viruses resulting from insertion of foreign DNA sequences in the EIA and MLP regions may be rescued by growth in 293 cells or be co-transfection with a helper virus providing the missing function in trans . The herpes simplex virus which displays a natural tropism for the nervous system, may be modified to infect hepatocytes or endothelial cells and to contain desired nucleotide sequences that encode ApoA-I peptides. For example, the cassettes encoding heteropolymers of ApoA-I peptides may be advantageously engineered downstream of an early promoter region of HSV such as the ICP4 gene sequences or the VP16 gene sequences in order to enhance expression of these sequences. Several structural genes of HSV can be targeted for the insertion of foreign DNA sequences for the purpose of engineering recombinant viruses. For example, the nucleotide sequences encoding the structural glycoproteins, gB, gD and gH can serve as regions to insert foreign DNA sequences. However, those gene products which have been replaced and/or disrupted would be supplied in trans , either by vector and/or expressed by host cells in order to produce virus stocks of the resulting recombinant viruses. Human retroviruses may be used to , e.g. HTLV-1 and HTLV-2 or animal retroviruses which display a tropism for human lymphocytes, e.g. , Bovine leukemia virus, Moloney murine leukemia virus, Rous-associated virus, and feline leukemia virus, may be used to target liver cells. Sequences required for retroviral replication are located in the LTR, therefore, foreign DNA sequences, i.e.. coding sequences of the ApoA-I peptide of interest may be inserted downstream. In retrovirus-infected cells, viral transcription occurs from the integrated viral DNAs, the provirus, which represents a transcriptional unit that contains its own regulatory sequences. Expression of the provirus depends on (1) the site into which the provirus has integrated; (2) the physiological state of the cell; and (3) the viral LTR. The expression of the provirus depends almost entirely on host- encoded enzymes. The viral LTR is derived from three segments of the viral RNA: the R, U5 and U3 sequences. The R or redundant sequence is a short segment (30 to 60 nucleotides) that is present twice in the viral RNA, at the extreme left (5') and right (3') termini. The U5 sequences are present at the 5' end of the viral RNA. The U3 sequences are located upstream from the R sequences and have the most variation in size (0.2 to 1.2 kb) and sequence homology. Viral specific regulation of expression depends principally on the long terminal repeat (LTR) which contains signals for enhancement, promotion, initiation and polyadenylation of RNA synthesis. Transcription is initiated at the left end of the R sequences in the left-hand LTR. Viral transcription is catalyzed by a cellular type II RNA polymerase and is polyadenylated post-transcriptionally near the right hand end of the right LTR. The U3 regions of all LTRs possess CCAAT and TATAA boxes. Enhancer function has been localized to a repeat sequence of variable length (72 to 101 nucleotides) that is found in U3, upstream from the 5 promoter domain. Sequences in U3 of the Moloney murine leukemia virus (MMTV) LTR have also been found to be responsible for the enhanced level of virus expression in response to glucocorticoid treatment of MMTV-infected cells. Murine parvovirus (MVM) which displays a natural 10 tropism for human T cells, may be modified to infect hepatocytes or the endothelial cells of the gut. In the case of MVM, the major cis-acting factors that are essential for the first steps in viral DNA replication are found upstream of the "early" promoter, P4 (Cotmore et al., 1992, Virology 15 190:365-377). The early promoter is the initiating promoter for viral transcription, and its TATAA box is located 4 map units from the left end of the MVM genome, at around nucleotide 150. The essential cis-acting functions for the origin of MVM DNA replication are also found in this region. 20 The insertion of foreign DNA sequences such as the coding sequences for the ApoA-1 peptides just downstream of this region places them under the regulation of viral gene expression without disruption of other essential viral activities, i.e. , DNA replication. 25 Vesicular stomatitis virus (VSV) , the prototypic rhabdovirus, can be used in gene therapy to express the ApoA- I peptides of the invention in mammalian cells. VSV is the simplest of enveloped animal viruses, grows to very high titers and can be prepared in large quantities. Foreign 30 glycoproteins may be incorporated into the VSV G envelope protein to target the viral vector to liver cells or cells of the small and large intestine. The VSV G gene is large enough to accommodate nucleotide sequences encoding the ApoA- I peptides of the invention. (See Schnell et al., 1996, 35 Proc. Natl. Acad. Sci. USA 93:11359-11365). Alphavirus-based expression vectors, a prototype of enveloped positive-strand RNA viruses, can also be engineered to mediate efficient expression of the nucleotides encoding the ApoA-I peptides of the invention. Although normally cytocidal for vertebrate cells, variants of alphavirus with adaptive mutations allow noncytopathic replication of alphaviral vectors. Nucleotide sequences encoding the ApoA-I peptides may be engineered into the structural gene of the replication defective alphavirus genome. Defective helper RNAs containing the cis-acting sequences required for replication as well as the RNA promoter to package the replication defective alphaviral vector (Frolov et al. , 1996, Proc. Natl. Acad. Sci. USA 93:11371-11377). In addition to VSV and alphavirus and viruses, including influenza, rhababviruses, parainfluenza virus and bunya virus, may also be engineered using similar techniques for the delivery and expression of the nucleotide sequences encoding the ApoA-I peptides of the present invention. The viral vectors described above are by way of example, and not by way of limitation of the present invention. Any viral vector which may be genetically engineered to safely administer the nucleotide sequences encoding ApoA-I peptides and agonists to the target cells may be used in accordance with the present invention. 5.2.2. HOST CELLS EXPRESSING ApoA-I The present invention encompasses the expression of ApoA-I and peptides exhibiting ApoA-1 activity as described above, in animal cells or cell lines, preferably human cell or cell lines which may then be administered in vivo. The host cells which may be used in accordance with the invention to express ApoA-I and peptides exhibiting ApoA-I activity, including, but are not limited to, fibroblasts, Caco-2 cells, epithelial cells, endothelial cells, muscle cells, hepatocytes, cells isolated from large and small intestine etc. In a preferred embodiment of the invention, hepatocytes and cells isolated from the small intestine are used as host cells to express ApoA-I and peptides exhibiting ApoA-I activity. The host cells of the present invention also have utility as a model system to further understand the role of ApoAI in lipid metabolism. The host cells of the present invention also have utility as a model system to further understand the role of ApoA-I in lipid metabolism. In one embodiment of the present invention, host cells are obtained from the recipient, that is the individual who is to receive the transduced cells, or from a donor. Examples of cells which may be genetically engineered in accordance with the present invention, include, but are not limited to, hepatocytes, gall bladder cells, cells of the small intestine, epithelial cells, and endothelial cells, including cells isolated from small and large blood vessels. The isolate cells may be transfected or transduced with the DNA and viral vectors described herein. The transduced cells may subsequently be grafted or transplanted into the recipient. In another embodiment of the present invention, both transient and permanent recombinant cell lines may be engineered in which the native apolipoprotein A, or any other apolipoprotein, coding sequence is replaced by the coding sequence for a modified preproapolipoprotein A-I, a modified proapolipoprotein A-I, a modified ApoA-I or an Apo A-I agonist. A host cell strain may be chosen which modulates the expression of the inserted sequences, or modifies and processes the gene product in the specific fashion desired. Such modification (e.g., glycosylation) and processing (e.g. cleavage) of protein products may be important for the function of the protein. Different host cells have characteristic and specific mechanisms for the post- translational processing and modification of proteins and gene products. Appropriate cell lines or host systems can be chosen to ensure the correct modification of the foreign protein expressed. To this end, eukaryotic host cells which possess the cellular machinery for proper processing of the primary transcript, glycosylation, and phosphorylation of the gene product may be used. Such mammalian host cells include but are not limited to CHO, VERO, BHK, HeLa, COS, MDCK, 293, 3T3 and WI38 cell lines. For long term, high-yield production of native ApoA-I or peptides having ApoA-I agonist activity mammalian host cells stably expressing these peptides may be engineered. Rather than using expression vectors which contain viral origins of replication, host cells can be transformed with DNA controlled by appropriate expression control elements (e.g., promoter, enhancer, sequences, transcription terminators, polyadenylation sites, etc.), and a selectable marker. Following the introduction of the foreign DNA, engineered cells may be allowed to grow for 1-2 days in an enriched media, and then are switched to a selective media. The selectable marker in the recombinant plasmid confers resistance to the selection and allows cells to stably integrate the plasmid into their chromosomes and grow to form foci which in turn can be cloned and expanded into cell lines. This method may advantageously be used to engineer cell lines. This method may advantageously be used to engineer cell lines which express the ApoA-I and ApoA-I peptide gene products. Such cell lines would be particularly useful in screening and evaluation of compounds that affect the endogenous activity of the ApoA-I and ApoA-I peptide gene product. A number of selection systems may be used, including but not limited to the herpes simplex virus thymidine kinase (Wigler, et al., 1977, Cell 11:223), hypoxanthine-guanine phosphoribosyltransferase (Szybalska & Szybalski, 1962, Proc. Natl. Acad. Sci. USA 48:2026), and adenine phosphoribosyltransferase (Lowy, et al., 1980, Cell 22:817) genes can be employed in tk " , hgprt " or aprt " cells, respectively. Also, antimetabolite resistance can be used as the basis of selection for the following genes: dhfr, which confers resistance to ethotrexate (Wigler, et al., 1980, Natl. Acad. Sci. USA 77:3567; O'Hare, et al., 1981, Proc. Natl. Acad. Sci. USA 78:1527); gpt, which confers resistance to mycophenolic acid (Mulligan & Berg, 1981, Proc. Natl. Acad. Sci. USA 78:2072); neo, which confers resistance to the aminoglycoside G-418 (Colberre-Garapin, et al., 1981, J. Mol. Biol. 150:1); and hygro, which confers resistance to hygromycin (Santerre, et al., 1984, Gene 30:147). For example, the cassettes encoding heteropolymers of ApoA-I peptides may be advantageously engineered into adenoviruses as described in detail above. 5.2.3. TRANSGENIC ANIMALS EXPRESSING APOA-I The invention also encompasses the expression of the ApoA-I nucleotide sequences of the present invention transgenic animals as a model system to further understand the role of ApoA-I in lipid metabolism in addition to having utility for gene therapy. Animals of any species, including, but not limited to, mice, rats, rabbits, guinea pigs, micro- pigs, goats, and non-human primates, e.g. , baboons, monkeys, and chimpanzees may be used to generate ApoA-I transgenic animals. Any technique known in the art may be used to introduce the ApoA-I transgene into animals to produce the founder lines of transgenic animals. Such techniques include, but are not limited to pronuclear microinjection (Hoppe, P.C. and Wagner, T.E., 1989, U.S. Pat. No. 4,873,191); retrovirus mediated gene transfer into germ lines (Van der Putten et al., 1985, Proc. Natl. Acad. Sci., USA 82:6148-6152); gene targeting in embryonic stem cells (Thompson et al., 1989, Cell 56:313-321); electroporation of embryos (Lo, 1983, Mol Cell. Biol. 3:1803-1814); and sperm- mediated gene transfer (Lavitrano et al., 1989, Cell 57:717- 723) ; etc. For a review of such techniques, see Gordon, 1989, Transgenic Animals, Intl. Rev. Cytol. 115:171-229, which is incorporated by reference herein in its entirety. The present invention provides for transgenic animals that carry the ApoA-I transgene in all their cells, as well as animals which carry the transgene in some, but not all their cells, i.e. , mosaic animals. The transgene may be integrated as a single transgene or in concatamers, e.g.. head-to-head tandems or head-to-tail tandems. The transgene may also be selectively introduced into and activated in a particular cell type by following, for example, the teaching of Lasko et al. (Lasko, M. et al., 1992, Proc. Natl. Acad. Sci. USA 89: 6232-6236). The regulatory sequences required for such a cell-type specific activation will depend upon the particular cell type of interest, and will be apparent to those of skill in the art. When it is desired that the ApoA- I transgene be integrated into the chromosomal site of the endogenous ApoA-I gene, gene targeting is preferred. Briefly, when such a technique is to be utilized, vectors containing some nucleotide sequences homologous to the endogenous ApoA-I gene are designed for the purpose of integrating, via homologous recombination with chromosomal sequences, into and disrupting the function of the nucleotide sequence of the endogenous ApoA-I gene. The transgene may also be selectively introduced into a particular cell type, thus inactivating the endogenous ApoA-I gene in only that cell type, by following, for example, the teaching of Gu et al. (Gu, et al., 1994, Science 265: 103-106). The regulatory sequences required for such a cell-type specific inactivation will depend upon the particular cell type of interest, and will be apparent to those of skill in the art. 5.3. GENE THERAPY APPROACHES TO DELIVER ApoA-I PEPTIDES Gene therapy approaches may also be used in accordance with the present invention to deliver nucleotide sequences encoding native ApoA-I or ApoA-I peptides. The gene therapy approaches of the present invention can be used to treat any disorder in animals, especially mammals, including humans, for which increasing serum HDL concentration, activating LCAT, and promoting cholesterol efflux and RCT is beneficial. Such conditions include, but are not limited to hyperlipidemia, and especially hypercholestere ia, and cardiovascular disease such as atherosclerosis (including prevention of atherosclerosis and treatment of existing disease) ; restenosis (e.g.. preventing or treating atherosclerotic plaques which develop as a consequence of medical procedures such as balloon angioplasty) ; and other disorders, such as endotoxemia which often results in septic shock (e.g. , Gouni et al . , 1993, J. Lipid Research 94:139-146; Levine, WO96/04914) . The gene therapy approaches of the present invention can be used alone or in combination therapy with other drugs used to treat the foregoing conditions. Such therapies include, but are not limited to simultaneous or sequential administration of the drugs involved. 5.3.1. GENE REPLACEMENT THERAPY With respect to an increase in the level of normal ApoA-I peptide expression and/or ApoA-I peptide product activity, ApoA-I peptide nucleic acid sequences, described, above, in Section 5.1, can, for example, be utilized for the treatment of dislipidemic or hyperlipidemic disorders Such treatment can be administered, for example, in the form of gene replacement therapy. Specifically, one or more copies of a normal ApoA-I peptide or a portion of the ApoA-I peptide that directs the production of a ApoA-I peptide product exhibiting normal ApoA-I peptide function, may be inserted into the appropriate cells within a patient, using vectors that include, but are not limited to adenovirus, adeno- associated virus, and retrovirus vectors, in addition to other particles that introduce DNA into cells, such as lipoεomes. Because the ApoA-I protein is expressed in the liver, such gene replacement therapy techniques should be capable delivering ApoA-I peptide sequences to these cell types within patients. In another embodiment, techniques for delivery involve direct administration of such ApoA-I peptide sequences to the site of the cells in which the ApoA-I peptide sequences are to be expresεed. Additional methodε that may be utilized to increaεe the overall level of ApoA-I peptide expression and/or ApoA-I peptide product activity include the introduction of appropriate ApoA-I expresεing cells, preferably autologous cells, into a patient at positionε and in numbers that are sufficient to ameliorate the symptoms of a hyperlipidemia disorder. Such cells may be either recombinant or non- recombinant. Among the cells that can be administered to increase the overall level of ApoA-I peptide expresεion in a patient are normal cells, preferably hepatocytes, that expresε the ApoA-I peptide. Alternatively, cells, preferably autologous cells, can be engineered to expreεs ApoA-I peptide sequences, and may then be introduced into a patient in positions appropriate for the amelioration of the symptoms of a dyslipidemia disorder. Alternately, cells that express an unimpaired ApoA-I peptide and that are from a MHC matched individual can be utilized, and may include, for example, hepatocytes. The expression of the ApoA-I peptide sequences is controlled by the appropriate gene regulatory sequences to allow such expresεion in the necesεary cell typeε. Such gene regulatory sequences are well known to the skilled artisan. Such cell-based gene therapy techniques are well known to those skilled in the art, see, e.g., Anderson, U.S. Patent No. 5,399,349 incorporated herein by reference in its entirety. When the cells to be administered are non- autologouε cellε, they can be adminiεtered using well known techniques that prevent a host immune response against the introduced cells from developing. For example, the cells may be introduced in an encapsulated form which, while allowing for an exchange of components with the immediate extracellular environment, doeε not allow the introduced cells to be recognized by the host immune system. 5.3.2. DELIVERY OF NUCLEIC ACIDS IN VIVO Delivery of the nucleic acid into a patient may be either direct, in which case the patient is directly exposed to the nucleic acid or nucleic acid-carrying vector, or indirect, in which case, cells are first transformed with the nucleic acid in vitro, then transplanted into the patient for cell replacement therapy. These two approaches are known, respectively, as in vivo or ex vivo gene therapy. In a specific embodiment, the nucleic acid is directly administered in vivo , where it is expressed to produce the encoded product. This can be accomplished by any of numerous methods known in the art, e.g., by constructing it as part of an appropriate nucleic acid expression vector and administering it so that it becomes intracellular, e.g., by infection using a defective or attenuated retroviral or other viral vector (see U.S. Patent No. 4,980,286), or by direct injection of naked DNA, or by use of microparticle bombardment (e.g., a gene gun; Biolistic, Dupont) , or coating with lipids or cell-surface receptors or transfecting agentε, encapsulation in liposomes, microparticles, or microcapsules, or by adminiεtering it in linkage to a peptide which is known to enter the cell or nucleus, e.g., by administering it in linkage to a ligand subject to receptor-mediated endocytosis (see e.g., Wu and Wu, 1987, J. Biol. Chem. 262:4429-4432) (which can be used to target cell types specifically expressing the receptors) , etc. In a specific embodiment, the nucleic acid can be targeted in vivo for cell specific uptake and expression, by targeting a specific receptor (see, e.g., PCT Publications WO 92/06180 dated April 16, 1992 (Wu et al.); WO 92/22635 dated December 23, 1992 (Wilson et al.); WO92/20316 dated November 26, 1992 (Findeis et al.); W093/14188 dated July 22, 1993 (Clarke et al.), WO 93/20221 dated October 14, 1993 (Young)). In another embodiment, a nucleic acid-ligand complex can be formed in which the ligand comprises a fusogenic viral peptide to disrupt endosomes, allowing the nucleic acid to avoid lysosomal degradation. Alternatively, the nucleic acid can be introduced intracellularly and incorporated within host cell DNA for expression, by homologous recombination (Koller & Smithies, 1989, Proc. Natl. Acad. Sci. USA 86:8932-8935; Zijlstra et al., 1989, Nature 342:435-438). In yet another embodiment, the nucleic acid may be administered in vivo by a time controlled release device. The nucleic acid may also be administered in vivo by a device which contains cells expreεsing the ApoA-I peptides and agonists of the present invention, protecting them from rejection by the recipient or host. In accordance with this device, the proteins and peptides may diffuse through a permeable membrane which has a molecular weight cut off of approximately 3,500 to 50,000 daltons. One εtrategy for targeting DNA or viral vectorε hepatocyteε can be based on the presence of the asialoglycoprotein (ASPG) receptor on hepatocytes. This receptor is specifically expressed on the cell surface of hepatocyteε. Asialoglycopeptide-protein conjugates and asialoglycopeptide-coated vesicles have been uεed to εpecifically deliver to a variety .of bioactive agents to the liver .in vivo. Aitie et al . , 1980, Proc. Natl. Acad. Sci. 27:5923-5927; Hildenbrandt et al . , 1980, BBA 631:499-502. Another strategy to targeting delivery of nucleotide sequences to hepatocytes is to genetically modify viral vectors, i.e. adenoviruses and retroviruεes to express ligands for the ASPG receptors. Internalization of virus occurs through the specific interaction of the viral envelope with a cell surface receptor, followed by receptor-mediated endocytosiε of the virus/receptor complex. The viral vectors which may be used in accordance with the present invention are discussed above in Section 5.2.2. 5.3.3. DELIVERY OF NUCLEIC ACIDS EX VIVO Another approach to gene therapy, for use in the cell replacement therapy of the invention, involveε transferring a gene to cells in tiεsue culture by such methods as electroporation, lipofection, calcium phosphate mediated transfection, or viral infection. Usually, the method of transfer includes the transfer of a selectable marker to the cells. The cells are then placed under selection to isolate those cells that have taken up and are expressing the transferred gene. Those cells are then delivered to a patient. In this embodiment, the nucleic acid is introduced into a cell prior to administration in vivo of the resulting recombinant cell. Such introduction can be carried out by any method known in the art, including, but not limited to, transfection, electroporation, microinjection, infection with a viral vector containing the nucleic acid sequences, cell fusion, chromosome-mediated gene transfer, microcell-mediated gene transfer, spheroplast fusion, etc. Numerous techniques are known in the art for the introduction of foreign genes into cells (see e.g., Loeffler & Behr, 1993, Meth. Enzymol. 217:599-618; Cohen et al., 1993, Meth. Enzymol. 217:618-644; Cline, 1985, Pharmac. Ther. 29:69-92) and may be used in accordance with the present invention, provided that the necessary developmental and physiological functions of the recipient cells are not disrupted. The technique εhould provide for the εtable transfer of the nucleic acid to the cell, so that the nucleic acid is expressible by the cell and preferably heritable and expressible by its cell progeny. The resulting recombinant cells can be delivered to a patient by various methods known in the art. In a preferred embodiment, epithelial cells are injected, e.g., subcutaneously. In another embodiment, recombinant skin cells (e.g., keratinocytes) may be applied aε a skin graft onto the patient. Recombinant blood cells (e.g., he atopoietic stem or progenitor cells) are preferably administered intravenously. The amount of cells envisioned for use depends on the desired effect, patient state, etc., and can be determined by one skilled in the art. In an embodiment in which recombinant cells are used in gene therapy, nucleotides which encode a gene or promoter suppressor are introduced into the cells such that it is expressible by the cells or their progeny, and the recombinant cells are then administered in vivo for therapeutic effect. In a specific embodiment, stem or progenitor cells are used. Any stem and/or progenitor cells which can be isolated and maintained in vitro can potentially be used in accordance with this embodiment of the present invention. By way of example, and not by limitation, for ex vivo gene therapy approaches, the following procedures may be utilized for the isolation of hepatocytes to be genetically engineered to express the ApoA-I peptides of the present invention and the grafting or transplantation of the engineered hepatocytes into the recipient. In this embodiment, hepatocytes are obtained from a donor or a recipient, the individual who is to receive the engineered hepatocyteε. Thiε procedure entailε removing a portion of a liver, from which hepatocytes are removed by in situ perfusion of a collagenase solution. If the hepatocytes are to be isolated from an intact liver, a catheter is inεerted into a vein which either leaves or enters the liver, collagenase solution is perfused through the catheterized vessels, resulting in releaεe of hepatocytes. Once removed or isolated, the hepatocytes are plated and maintained under conditions suitable for transfection. For example, several methods have been described for isolating highly enriched populations of rat hepatocytes and maintaining these cellε in culture for extended periods of time. Koch, K.S. and H.L. Leffert, Annals N.Y. Academy of Sciences, 349:111-127 (1980); McGowan, J.A. et al., Journal of Cellular Physiology, 108:353-363 (1981); Bisεell, D.M. and P.S. Guzelian, Annals of the New York Academy of Sciences, 349:85-98 (1981); and Enat, R. et al., Proceedingε of the National Academy of Scienceε, U.S.A., 81:1411-1415 (1984). Such methodε can be uεed to isolate and maintain hepatocytes to be transduced by the method of the present invention. Hepatocytes can also be prepared uεing a modification of the procedure developed by Barry and Friend, deεcribed below and in Example 1, with the perfusion mixture described by Leffert. Leffert, H.L. et al.. Methods in Enzymology, 58:536-544 (1979), the teachings of which are incorporated herein by reference. The genetic material incorporated into and expressed by hepatocytes can also, optionally, include genetic material encoding a selectable marker, thus making it possible to identify and select cells which contain and express the genetic material of interest. Thus, DNA or RNA introduced into cultured hepatocytes of the present invention includes the genetic material (DNA or RNA) of intereεt and, optionally, genetic material encoding a εelectable marker; εuch DNA or RNA is referred to as incorporated genetic material (or incorporated DNA, incorporated RNA) . Hepatocytes containing incorporated genetic material are referred to as transduced hepatocyteε; they express the DNA or RNA of interest and produce the encoded protein or polypeptide. Exogenous DNA encoding a polypeptide or protein of interest and, optionally, a selectable marker (e.g. , neo, which encodes neomycin resiεtance) iε incorporated .in vitro into hepatocytes as described below and in Examples I-III. Hepatocytes isolated as described previously are plated at subconfluent density on matrix subεtrata and maintained in hormonally defined media, such as that described by Enat et al., the teachings of which are incorporated herein by reference. Enat, R. , et al., Proceedings of the National Academy of Sciences, USA, 81:1411-1415 (1984). The media is changed as needed to maintain the hepatocyteε. Cells are subεequently infected with an amphotropic retroviruε which containε DNA of interest (e.g. , DNA encoding a polypeptide whose expression in hepatocytes is desired) and, optionally, DNA encoding a selectable marker to be incorporated into the hepatocytes. The hepatocytes are infected with the recombinant adenovirus or retrovirus (and thus transduced with the DNA of interest) by exposing them to virus which has a recombinant genome. This reεults in infection of the cells by the recombinant retroviruε. It is posεible to optimize the conditions for infection of the hepatocytes by using a high titer amphotropic viruε. Viral εtockε, to be used in introducing genetic material of interest into hepatocytes, are harvested, as described above, supplemented with Polybrene (Aldrich) and added to the culture of hepatocytes. If the titer of the virus is high (e.g. , approximately lθ 6 cfu per ml.), then virtually all hepatocytes will be infected and no selection of transduced hepatocytes is required. If the titer is very low, then it is necessary to use a retroviral vector that has a selectable marker, such as neo or his. If a selectable marker is used, after exposure to the virus, the cellε are grown to confluence and εplit into selective media (e.g. , media containing G418 if the selectable marker is neo, media containing histidinol and no histidine if the selectable marker is his) . Hepatocytes expreεεing the incorporated genetic material are grown to confluence in tiεεue culture veεεels; removed from the culture vessel; and introduced into the body. Thiε can be done surgically, for example. In thiε case, the tiεεue which iε made up of transduced hepatocytes capable of expresεing the nucleotide sequence of intereεt iε grafted or transplanted into the body. For example, it can be placed in the abdominal cavity in contact with/grafted onto the liver or in close proximity to the liver. Alternatively, the transduced hepatocyte-containing tissue can be attached to microcarrier beads, which are introduced (e.g. , by injection) into the peritoneal space of the recipient. This approach has been shown to be successful by transplantation of wild type hepatocytes into a strain of rats (Nagase analbuminemic rats) which are deficient in albumin synthesiε and de onεtration of moderate levelε of albumin in serum of transplanted animals. Direct injection of genetically modified hepatocytes into the liver may also be posεible. Once introduced into the body of an individual, the transduced hepatocytes provide a continuous supply of the hormone, enzyme or drug encoded by the genetic material of interest. The amount of the hormone, enzyme or drug supplied 5 in this way can be modified or regulated as needed (e.g. , by using external cues or factors which control or affect production, by controlling the size of the graft or the quantity of fibroblasts introduced into the body, or by removing the graft) . 0 5.4. PHARMACEUTICAL FORMULATIONS AND METHODS OF ADMINISTRATION The present invention encompasεes pharmaceutical formulations for the delivery of DNA or viral vectors encoding ApoA-I or ApoA-I peptides for .in vivo transformation of cells or the delivery of host cells transformed with DNA or viral vectors for m vivo and ex vivo gene therapy approaches. The ApoA-I agonistε of the invention can be used to treat any disorder in animals, especially mammals including humans, for which increasing serum HDL concentration, activating LCAT, and promoting choleεterol efflux and RCT iε beneficial. Such conditionε include, but are not limited to hyperlipidemia, and especially hypercholesteremia, and __ cardiovaεcular disease such as atheroscleroεiε (including prevention of atherosclerosis and treatment of existing diseaεe) ; restenosis (e.g. , preventing or treating atherosclerotic plaques which develop as a conεequence of medical procedures such as balloon angioplasty) ; and other 30 disorders, such as endotoxin-induced shock which often results in hypertriglyceridemia (see, e.g.. Gouni et al., 1993, J. Lipid Research 94:139-146; Levine, WO96/04914) . The ApoA-I agonists can be used alone or in combination therapy with other drugs used to treat the 3 _ foregoing conditions. Such therapies include, but are not limited to simultaneous or sequential administration of the drugs involved. For example, in the treatment of hypercholesterolemia or atherosclerosis, mammalian host cells expresεing the ApoA-I agoniεt formulations can be administered with any one or more of the cholesterol lowering therapies currently in use; e.g. , bile-acid resinε, niacin, and/or statins. Such a combined regimen may produce particularly beneficial therapeutic effects since each drug acts on a different target in cholesterol synthesis and transport; i.e. , bile-acid resins affect cholesterol recycling, the chylomicron and LDL population; niacin primarily affects the VLDL and LDL population; the εtatinε inhibit cholesterol synthesis, decreasing the LDL population (and perhaps increasing LDL receptor expreεεion) ; whereas the ApoA-I agonistε affect RCT, increaεe HDL, increaεe LCAT activity and promote choleεterol efflux. In another embodiment, mammalian host cells expressing ApoA-I agonists may be used in conjunction with fibrate to treat hyperlipidemia, hypercholesterolemia and/or cardiovascular disease such as atheroεcleroεiε. Thiε regimen may likewiεe prove very beneficial εince fibrate doeε not have a proven effect on cardiovaεcular disease. In yet another embodiment, the ApoA-I agoniεtε of the invention can be uεed in combination with the antimicrobials and anti-inflammatory agents currently used to treat septic shock induced by endotoxin. The ApoA-I agonistε expreεsed by the nucleotide sequences of the invention can be formulated as peptides or as peptide-lipid complexes which can be administered to subjects in a variety of ways to deliver the ApoA-1 agonist to the circulation. Exemplary formulations and treatment regimens are described below. The mammalian host cells expresεing ApoA-I peptide agoniεts, the DNA-lipid complexes or "naked" plasmid DNA encoding the ApoA-I agonists of the invention may be administered by any suitable route that ensureε bioavailability in the circulation. Thiε can best be achieved by parenteral routes of administration, including intravenous (IV) , intramuεcular (IM) , intradermal, subcutaneous (SC) and intraperitoneal (IP) injections. However, other routes of administration may be used. For example, absorption through the gastrointestinal tract can be accomplished by oral routes of administration (including but not limited to ingestion, buccal and sublingual routes) provided appropriate formulations (e.g. , enteric coatings) are used to avoid or minimize degradation of the active ingredient, e.g.. in the harsh environments of the oral mucoεa, stomach and/or small intestine. Furthermore, one may administer the agent of the present invention in a targeted drug delivery syεtem, for example in a lipoεome targeted to the liver. The liposomes will be targeted to an taken up selectively by liver cells. Alternatively, administration via mucosal tisεue εuch as vaginal and rectal modes of administration may be utilized to avoid or minimize degradation in the gastrointestinal tract. In yet another alternative, the formulations of the invention can be administered tranεcutaneously (e.g.. transdermally) , or by inhalation. It will be appreciated that the preferred route may vary with the condition, age and compliance of the recipient. The actual doεe of ApoA-I agonists or peptide-lipid complex used will vary with the route of administration, and should be adjusted to achieve circulating plasma concentrations of 100 mg to 2g/l. Data obtained in animal model systems described herein show that the ApoA-I agonists of the invention associate with the HDL component, and have a projected half-life in humans of about five days. Thus, in one embodiment, the ApoA-I agonists can be administered by injection at a dose between 0.5 to 100 mg/kg (dose/IV;IM;SC) once a week. In another embodiment, desirable serum levels may be maintained by continuous infusion to provide about 0.5 - 100 mg/kg/hr or by intermittent infusion providing about 0.5 - 100 mg/kg. Toxicity and therapeutic efficacy of the various ApoA-I agonists can be determined using standard pharmaceutical procedures in cell culture or experimental animals for determining the LD 50 (the dose lethal to 50% of the population) and the ED 50 (the dose therapeutically effective in 50% of the population) . The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD 50 /ED 50 . ApoA-I peptide agonists which exhibit large therapeutic indices are preferred. 5.4.1. PHARMACEUTICAL FORMULATIONS The pharmaceutical formulation of the invention contain the mammalian host cells expressing the ApoA-I peptide agonist, the DNA encoding the ApoA-I peptide either naked or complexed with lipids, liposomeε, or nonlipid cationic polymerε as the active ingredient in a pharmaceutically acceptable carrier suitable for administration and delivery jLn vivo. Injectable preparations include sterile suspensionε, solutions or emulsionε of the active ingredient in aqueous or oily vehicles. The compositions may also contain formulating agents, such as suspending, stabilizing and/or disperεing agent. The formulationε for injection may be presented in unit dosage form, e.g. , in ampules or in multidose containers, and may contain added preservatives. Alternatively, the injectable formulation may be provided in powder form for reconstitution with a suitable vehicle, including but not limited to sterile pyrogen free water, buffer, dextrose solution, etc., before use. To this end, the ApoA-I agonist peptide may be lyophilized, or the co-lyophilized peptide-lipid complex may be prepared. The stored preparations can be supplied in unit dosage forms and reconstituted prior to use in vivo. For prolonged delivery, the active ingredient can be formulated as a depot preparation, for adminiεtration by implantation; e.g. , subcutaneous, intradermal, or intramuscular injection. Thus, for example, the active ingredient may be formulated with suitable polymeric or hydrophobic materials (e.g. , as an emulsion in an acceptable oil) or ion exchange resinε, or aε εparingly εoluble derivativeε; e.g.. aε a sparingly soluble salt form of the ApoA-I agonist. Alternatively, transdermal delivery systems manufactured as an adheεive disc or patch which slowly releaεeε the active ingredient for percutaneouε abεorption may be uεed. To thiε end, permeation enhancers may be used to facilitate transdermal penetration of the active ingredient. A particular benefit may be achieved by incorporating the ApoA-I agonists of the invention or the peptide-lipid complex into a nitroglycerin patch for use in patients with ischemic heart disease and hypercholesterolemia. For oral administration, the pharmaceutical compositions may take the form of, for example, tablets or capsules prepared by conventional means with pharmaceutically acceptable excipients εuch aε binding agentε (e.g.. pregelatiniεed maize εtarch, polyvinylpyrrolidone or hydroxypropyl ethylcelluloεe) ; fillerε (e.g. , lactoεe, microcryεtalline cellulose or calcium hydrogen phosphate) ; lubricants (e.g. , magnesium stearate, talc or silica) ; disintegrants (e.g. , potato εtarch or εodium εtarch glycolate) ; or wetting agentε (e.g. , εodium lauryl εulphate) . The tabletε may be coated by methodε well known in the art. Liquid preparationε for oral administration may take the form of, for example, solutions, syrups or suspenεions, or they may be presented as a dry product for constitution with water or other suitable vehicle before use. Such liquid preparations may be prepared by conventional meanε with pharmaceutically acceptable additives such aε suspending agents (e.g.. sorbitol syrup, cellulose derivatives or hydrogenated edible fats) ; emulsifying agents (e.g. , lecithin or acacia) ; non-aqueous vehicles (e.g. , almond oil, oily esterε, ethyl alcohol or fractionated vegetable oilε) ; and preservatives (e.g. , methyl or propyl-p-hydroxybenzoates or sorbic acid) . The preparationε may also contain buffer salts, flavoring, coloring and sweetening agents as appropriate. Preparations for oral administration may be suitably formulated to give controlled release of the active compound. For buccal administration, the compositions may take the form of tablets or lozenges formulated in conventional manner. For rectal and vaginal routes of administration, the active ingredient may be formulated as solutions (for retention enemas) suppositorieε or ointments. For administration by inhalation, the active ingredient can be conveniently delivered in the form of an aerosol spray presentation from pressurized packs or a nebulizer, with the use of a suitable propellant, e.g.. dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gaε. In the case of a presεurized aerosol the dosage unit may be determined by providing a valve to deliver a metered amount. Capsules and cartridges of e.g. gelatin for use in an inhaler or inεufflator may be formulated containing a powder mix of the compound and a suitable powder base such as lactose or starch. The compositions may, if desired, be presented in a pack or dispenser device which may contain one or more unit dosage forms containing the active ingredient. The pack may for example comprise metal or plastic foil, such as a blister pack. The pack or dispenser device may be accompanied by instructions for administration. 5.5. OTHER USES The ApoA-I peptides and agonists encoded by the nucleotide sequenceε of the invention can be used in asεays in vitro to measure serum HDL, e.g.. for diagnostic purposeε. Becauεe the ApoA-I agonists associate with the HDL component of serum, the agonistε can be uεed aε "markerε" for the HDL population. Moreover, the agonists can be used as markers for the subpopulation of HDL that are effective in RCT. To this end, the agonist can be added to or mixed with a patient serum sample; after an appropriate incubation time, the HDL component can be asεayed by detecting the incorporated ApoA-I agonist. This can be accomplished using labeled agonist (e.g. , radiolabels, fluorescent labels, enzyme labels, dyes, etc.), or by immunoasεays using antibodies (or antibody fragments) specific for the agonist. Alternatively, labeled agonist can be used in imaging procedures (e.g.. CAT scans, MRI scans) to visualize the circulatory syεtem, or to monitor RCT, or to visualize accumulation of HDL at fatty streaks, atherosclerotic lesions, etc. (where the HDL should be active in cholesterol efflux) . 6. EXAMPLE: LCAT ACTIVATION ASSAY Examples of peptides which may be encoded by the nucleotides of the present invention are listed in Table VIII which also includes peptides which are chemically synthesized. Only those peptides composed of amino acids which may be genetically encoded or which exhibit an LCAT activity of less than 38% as compared with native ApoA-I are encompassed by the present invention. All of the peptides listed were analyzed m vitro for their ability to activate LCAT. In the LCAT asεay, εubstrate vesicles (small unilamellar vesicles or "SUVs") composed of egg phophatidylcholine or l-Palmitoyl-2-oleyl-phosphatidyl- choline (POPC) and radiolabelled cholesterol are preincubated with equivalent masses either of peptide or ApoA-I (isolated from human plasma) . The reaction is initiated by addition of LCAT (purified from human plasma) . Native ApoA-I, which was used as positive control, represents 100% activation activity. "Specific activity" (i.e. , units of activity (LCAT activation) /unit of masε) of the peptideε can be calculated aε the concentration of peptide that achieves maximum LCAT activation. For example, a series of concentrations of the peptide (e.g. , a limiting dilution) can be asεayed to determine the "specific activity" for the peptide — the concentration which achieves maximal LCAT activation (i.e. , percentage conversion of cholesterol to choleεterol eεter) at a specific timepoint in the assay (e.g. , 1 hr.). When plotting percentage conversion of cholesterol at, e.g. , 1 hr., against the concentration of peptide used, the "specific activity" can be identified aε the concentration of peptide that achieves a plateau on the plottal curve. 6.1. PREPARATION OF SUBSTRATE VESICLES The vesicleε uεed in the LCAT aεεay are SUVε compoεed of egg phoεphatidylcholine (EPC) or l-palmitoyl-2- oleyl-phoεphatidylcholine (POPC) and choleεterol with a molar ratio of 20:1. To prepare a veεicle εtock solution sufficient for 40 assayε, 7.7 mg EPC (or 7.6 mg POPC; 10 μmol) , 78 μg (0.2 μ ol) 4- 14 C-choleεterol, 116 μg choleεterol (0.3 μmol) are dissolved in 5 ml xylene and lyophilized. Thereafter 4 ml of asεay buffer iε added to the dry powder and sonicated under nitrogen atmosphere at 4°C. Sonication conditions: Branson 250 sonicator, 10 mm tip, 6.5 minuteε; Aεεay buffer: lOmM Triε, 0.14M NaCl, ImM EDTA, pH 7.4). The εonicated mixture iε centrifuged 6 times for 5 minutes each time at 14,000 rpm (Ϊ6,000x g) to remove titanium particles. The resulting clear solution is used for the enzyme asεay. 6.2. PURIFICATION OF LCAT For the LCAT purification, dextran sulfate/Mg 2+ treatment of human plasma is used to obtain lipoprotein deficient serum (LPDS) , which is sequentially chromatographed on Phenylsepharose, Affigelblue, ConcanavalinA sepharose and anti-ApoA-I affinity chromatography, as summarized for a representative purification m Table VII, below: TABLE VII LCAT PURIFICATION Fraction Total Total Total Yield Purificati Volume Protein Activity <*) on (mL) (mg) (nmol CE/mg*h) (fold) Plasma 550 44550 63706 LPDS 500 31000 62620 98 1.4 Phenyl 210 363 51909 82 100 sepharose Affigel 95 153 25092 39 115 blue ConA 43 36 11245 18 220 sepharose Anti-A-I 120 3.5 5500 9 1109 Affinity 6.2.1. PREPARATION OF LPDS To prepare LPDS, 500 ml plasma iε added to 50 ml dextran sulfate (MW=500000) solution. Stir 20 minutes. Centrifuge for 30 minutes at 3000 rpm (16,000 x g) at 4°C. Use supernatant (LPDS) for further purification (ca. 500 ml) 6.2.2. PHENYLSEPHAROSE CHROMATOGRAPHY The following materials and conditions were used for the phenylsepharoεe chromatography. solid phase: Phenylsepharose fast flow, high subst. grade, Pharmacia column: XK26/40, gel bed height: 33 cm, V=ca. 175 ml flow rateε 200 ml/hr (sample) wash: 200 ml/hr (buffer) elution: 80 ml/hr (distilled water) buffer: 10 mM Tris, 140 mM NaCl, ImM EDTA pH7.4, 0.01% Na-azide. Equilibrate the column in Tris-buffer, add 29 g NaCl to 500 ml LPDS and apply to the column. Waεh with several volumes of Tris buffer until the absorption at 280 nm wavelength iε approximately at the baεeline, then εtart the elution with diεtilled water. The fractionε containing protein are pooled (pool size: 180 ml) and used for Affigelblue chromatography. 6.2.3. AFFIGELBLUE CHROMATOGRAPHY The Phenylsepharoεe pool is dialyzed overnight at 4°C against 20 mM Tris-HCl, pH7.4, 0.01% Na-azide. The pool volume is reduced by ultrafiltration (Amicon YM30) to 50 - 60 ml and loaded on an Affigelblue column. solid phase: Affigelblue, Biorad, 153-7301 column, XK26/20, gel bed height: ca. 13 cm; column volume: approx. 70 ml. flow rates: loading: 15 ml/h wash: 50 ml/h Equilibrate column in Tris-buffer. Apply Phenylsepharose pool to column. Start in parallel to collect fractions. Wash with Tris-buffer. The pooled fractions (170 ml) were used for ConA chromatography. 6.2.4. ConA CHROMATOGRAPHY The Affigelblue pool waε reduced via Amicon (YM30) to 30-40 ml and dialyzed againεt ConA starting buffer (ImM Tris HC1 pH7.4; ImM MgCl 2 , ImM MnCl 2 , ImM CaCl 2 , 0.01% Na- azide) overnight at 4°C. εolid phase: ConA sepharose (Pharmacia) column: XK26/20, gel bed height: 14 cm (75 ml) flow rates: loading 40 ml/h washing (with starting buffer) : 90 ml/h elution: 50 ml/h, 0.2M Methyl-α-D-mannoside in ImM Tris, pH 7.4. The protein fractions of the mannoside elutionε were collected (110 ml) , and the volume was reduced by ultrafiltration (YM30) to 44 ml. The ConA pool was divided in 2 ml aliquots, which are stored at -20°C. 6.2.5. ANTI-ApoA-I AFFINITY CHROMATOGRAPHY Anti-ApoA-I affinity chromatography was performed on Affigel-Hz material (Biorad) , to which the anti-ApoA-I abs have been coupled covalently. column: XK16/20, V=16 ml. The column was equilibrated with PBS pH 7.4. Two ml of the ConA pool was dialyzed for 2 hours against PBS before loading onto the column. flow rates: loading: 15 ml/hour washing (PBS) 40 ml/hour. The pooled protein fractions (V=14 ml) are used for LCAT assayε. The column is regenerated with 0.1 M. Citrate buffer (pH 4.5) to elute bound A-I (100 ml), and immediately after this procedure reequilibrated with PBS. 6.3. RESULTS The results of the LCAT activation assay are presented in Table VIII, infra. TABLE VIII LCAT ACTIVATION EXHIBITED BY EXEMPLARY CORE PEPTIDES VO en 25 IX) 25 Xt [A 13 ] -Consensus 22-mer peptide (Anantharamaiah et al., 1990, Arteriosclerosis 10 (1) :95-105) 5 0 [R 13 ] -Consensus 22-mer peptide (Anantharamaiah et al., 1990, Arteriosclerosis 10 (1) :95-105) 5 5 o ro 25 o CO 25 o n 20ID-3 peptide (Labeur et al., 1997, Arteriosclerosis, Thrombosis and Vascular Biology 17(3) :580- 588) . 5 Ac-18AMOD-C(0)NH 2 peptide (Epand et al., 1987, J. Biol. Chem. 262 (19) : 9389-9396) . 6 Ac-18AM4-C(0)NH 2 peptide (Brasseur, 1993, Biochim. Biophys. Acta 1170:1-7). 25 10 o cπ j elδL peptide (Segrest et al., 1990, Proteins: Structure, Function and Genetics 8:103-117). 8 18A peptide (Anantharamaiah et al., 1985, J. Biol. Chem. 260 (18) : 10248-10255) . 9 18AM4 peptide (Rosseneu et al., 093/25581; Corijn et al., 1993, Biochim. Biophys. Acta 1170:8- 16) . 10 [GI U I . 8 . Leu 5 ' 11 17 ]18A peptide (Epand et al. , 1987, J. Biol. Chem. 262 (19) :9389-9396) . 20 11 Ac-18AM3-C(0)NH 2 (Rosseneu et al., 093/25581) . 1 Ac-18AM2-C(0)NH 2 (Rosseneu et al. , W093/25581) . 13 Ac-18AM1-C(0)NH 2 (Rosseneu et al., W093/25581) . 25 In TABLE X, * indicates peptides that are N-terminal acetylated and C-terminal amidated; ' indicates peptides that are N-terminal dansylated; sp indicates peptides that exhibited solubility problems under the experimental conditions; X is Aib; Z is Nal; O is Orn; He (%) designates percent helicity; mics designates micelles; and - indicates deleted amino acidε. 7. EXAMPLE: STRUCTURAL AND LIPID BINDING ANALYSIS OF APOA-I PEPTIDES The structural and lipid binding characteristicε of the purified peptides syntheεized aε described in Section 6, supra , were determined by circular dichrois (CD) , fluoreεcence εpectroscopy and nuclear magnetic resonance (NMR) . 7.1. CIRCULAR DICHROISM This Example describes a preferred method for determining the percentage of α-helical secondary structure of the peptides alone and in the presence of lipids. 7.1.1 EXPERIMENTAL METHOD Far UV circular dichroism spectra were recorded between 190 and 260 nm (in 0.5 nm or 0.2 nm increments) with a AVIV62DS spectrometer (AVIV Associates, Lakewood, NJ, USA) equipped with a thermoelectric cell holder and sample changer. The instrument was calibrated with (+)-10- camphoric acid. Between one and three scans were collected for each sample, using 10 cm, 5 cm, 1 cm and 0.1 cm path length quartz Suprasil cellε, reεpectively, for peptide concentrationε of 10 ~7 M to 10 '4 M. The bandwidth waε fixed at 1.5 nm and the εcan εpeed to Is per wavelength step. The reported data are the mean of at least 2 or 3 independent measurementε . After background εubεtraction, εpectra were converted to molar ellipticity ( θ ) per reεidue in deg. cm "2 dmolY The peptide concentration was determined by amino acid analysis and also by absorption spectrometry on a Perkin Elmer Lambda 17 UV/Visible spectrophotometer when the peptide contained a chromophore (tryptophane, dansyl, naphtylalanine) . CD εpectra were obtained with free, unbound peptide (5 μM in 5 mM phosphate buffer, pH 7.4); with peptide-SUV complexes (20:1 EPC:Chol., Ri=50) ; with peptide-micelle complexes (l-myristoyl-2-hydroxy-sn-glycero-3-phosphatidyl choline, Ri=100) ; and with free, unbound peptide in the presence of 2,2, 2-trifluoroethanol (TFE) (5 μM peptide, 90% vol TFE) . The SUVs were obtained by dispersing the lipids (10 mM, 20:1 EPC:Chol., Avanti Polar Lipids, AL) in phoεphate buffer (5 mM, pH 7.4) with bubbling N 2 for 5 min., followed by sonication (1.5 hr.) in a bath sonicator. The homogeneity of the preparation was checked by FPLC. The micelles were obtained by diεperεing the lipid (6 mM l-myristoyl-2-hydroxy-sn-glycero-3-phosphatidyl choline, Avanti Polar Lipidε, AL) in phoεphate buffer (5 mM, pH 7.4) with bubbling N 2 for 5 min., followed by vortexing. To obtain the peptide-SUV complexeε, SUVs were added to the peptide (5 μM in 5 mM phoεphate buffer, pH 7.4) at a phospholipid-peptide molar ratio (Ri) of 100. To obtain the peptide-micelle complexes, micelles were added to the peptide (5 μM in 5 mM phosphate buffer, pH 7.4) at a Ri of 100. All spectra were recorded at 37 °C. The stability of peptide 210 (SEQ ID NO: 210) as a function of temperature (both free in buffer and in micelles) was determined by recording spectra at a serieε of different temperatureε . The degree of helicity of peptide 210 (SEQ ID NO: 210) aε a function of concentration was also determined. 7.1.2 HELICITY DETERMINATION The degree of helicity of the peptides in the various conditions was determined from the mean residue ellipticity at 222 nm (Chen et al., 1974, Biochemistry 13:3350-3359) or by comparing the CD spectra obtained to reference spectra available on databases (16 helical reference spectra from Provencher & Glockner, 1981, Biochemistry 20:33-37; denatured protein reference spectra from Venyaminov et al., 1993, Anal. Biochem. 214:17-24) using the CONTIN curve-fitting algorithm version 2DP, CD-I pack (Aug. 1982) (Provencher, 1982, Comput. Phys. Commun. 27:213- 227, 229-242). Acceptable fit waε determined using the statistical analysis methodology provided by the CONTIN algorithm. The error of all methods was ±5% helicity. 7.1.3 RESULTS The degree of helicity (%) of the free, unbound peptides (free) , the peptide-SUV complexes (SUVε) , the peptide-micelle complexeε (mics) and the peptide-TFE solution (TFE) are reported in TABLE X, Section 8.3, infra. Peptide 210 (SEQ ID NO: 210) contains significant α- helical structure (63% helicity) in micelles. Moreover, the α-helical structure iε completely stable over a temperature range of 5°-45° C (data not shown) . The helicity of peptide 210 (SEQ ID NO: 210) also increaεes in the presence of TFE, which is a solvent that, due to having a signficantly lower dielectric conεtant (e=26.7) than water (e=78.4), stabilizes α-helices and intrapeptide hydrogen bonds at concentrations between 5 - 90% (v/v) . Referring to TABLE VIII, infra, it can be εeen that those peptides which exhibit a high degree of LCAT activation (>38%) generally possess significant α-helical structure in the presence of lipids (>60% helical structure in the case of unblocked peptides containing 22 or more amino acids or blocked peptides containing 18 or fewer amino acids; >40% helical structure in the case of unblocked peptides containing 18 or fewer amino acids) , whereas peptides which exhibit little or no LCAT activation possess little α-helical structure. However, in some instances, peptides which contain significant α-helical structure in the presence of lipids do not exhibit εignificant LCAT activation. Aε a consequence, the ability of the core peptides of the invention to adopt an α-helical structure in the presence of lipids is considered a critical feature of the core peptides of the invention, as the ability to form an α-helix in the presence of lipids appears to be a prerequisite for LCAT activation. 7.2 FLUORESCENCE SPECTROSCOPY The lipid binding properties of the peptides described in Section 6, supra , were tested by fluorescence measurements with labeled peptides, in the present case Tryptophane (Trp or ) or Naphtylalanine (Nal) . The fluorescence spectra were recorded on a Fluoromax from Spex (Jobin-Yvon) equipped with a Xenon lamp of 150 , two monochromators (excitation and emisεion) , a photomultiplier R-928 for detection εensitive in the red up to 850 nm and a thermoelectric magnetic stirred cell holder. Quartz Suprasil cuvettes were used for measurements in the micromolar concentration range. A device of variable slits (from 0.4 to 5 nm) allows modulation of the incident and emitted intenεitieε according to the concentration of peptide uεed. The reported valueε are in general the average of between 2 to 4 εpectra. The peptide concentration iε determined by abεorption εpectrometry on a Philipε PU 8800 uεing the abεorption band of the Trp (e 280 in Triε buffer) or the Nal (e 224 nm =92 ,770 M^cm "1 in methanol) . Fluorescence spectra of the peptides were recorded between 290 nm and 450 nm in Tris-HCl buffer (20 mM, pH = 7.5), in the preεence and abεence of lipidic vesicles. The small unilamellar vesicles were formed after rehydration in buffer of the lyophilized phospholipids, dispersion and tip sonification under a N 2 εtream. The lipidε uεed were either Egg PC/Choi. (20:1) or POPC/Chol. (20:1). The spectra were recorded at a peptide concentration of 2μM and at a temperature of 37°C. The fluoreεcence reference εtandard in the case of Trp was N-acetyltryptophanylamide (NATA) . - Ill - Lipid binding studies were done through progressive lipidic vesicle addition to the peptide in solution at 2 μM (slits:5nm in excitation and 1.5 nm in emission). Dilution effects were taken into account for the fluorescence intensity determination. The lipid concentrations were varied from 10 to 600 μM and the molar ratio of lipid to peptide (Ri) was varied from 5 to 300. The wavelength of excitation was set at 280 nm for both Trp and Nal. 7.2.1 FLUORESCENCE SPECTRAL ANALYSIS The data were directly recorded and treated by an IBM-PC linked to the spectrofluorimeter through the DM3000F software from Spex. The spectra were corrected by εubstraction of the solvent contribution and by application of a coefficient given by the constructor taking into account the variation of the photomultiplier responεe verεuε the wavelength. The fluorescence spectra of the peptides were characterized by the wavelength at their maximum of fluorescence emisεion and by their quantum yield compared to NATA in the caεe of peptides labeled with a tryptophane. The process of binding to lipids was analyzed by calculating the shift of the wavelength at the maximum of fluorescence emiεsion, (λ max ) , and the variation of the relative fluorescence intensity of emiεsion versus the lipid concentration. The relative fluorescence intensity is defined as the following ratio: (I-I 0 max /lox max - I and I 0 are both measured at the (λ ∞x ) corresponding to the initial free state of the peptide, i.e. , without lipids. I is the intenεity at a defined lipid to peptide ratio and I 0 is the same parameter measured in absence of lipids. The abεence of theεe variationε iε relevant of the absence of interactionε of the peptideε with the lipids. 7.2.2 RESULTS AND DISCUSSION The lipid binding properties of peptide 199 (SEQ ID NO: 199), which is similar in primary sequence to peptide 210 (SEQ ID NO: 210) except that it contains a (Trp) residue at position 10, are presented in TABLE IX. TABLE IX BINDING PROPERTIES OF PEPTIDE 199 (SEQ ID NO: 199) TO LIPIDIC VESICLES AS MEASURED BY FLUORESCENCE Lipid: Peptide Molar Ratio (Ri) I/Io λ max (n ) 0 0 348 5 8 344 10 8 339 30 18 328 60 22 100 27 326 200 41 325 In buffer at a concentration of 2 μm, the maximum of the tryptophane fluorescence emission (λ max ) of peptide 199 (SEQ ID NO: 199) is 348 nm. This correspondε to a tryptophane which iε relatively exposed to the aqueous environment when compared to NATA (λ max=350 nm) . Peptide 199 (SEQ ID NO: 199) binds very effectively to EPC/Chol (20:1) small unilamellar vesicles aε demonstrated by the burying of the tryptophane (the wavelength for the tryptophane maximum fluorescence emission shifts from 348 nm to 325 nm) and the high fluorescence intensity exaltation (see Table IX) . The burying of the tryptophane residue is maximal for a lipid to peptide molar ratio of about 100. Other peptides which exhibited a high degree of helicity in the presence of lipids (>60% for unblocked peptideε of > 22 amino acidε, or blocked peptideε of < 18 amino acidε; > 40% for unblocked peptides of < 18 amino acids) as measured by circular dichroism aε diεclosed in Section 7.1, supra , also demonstrated good lipid binding. Of course, among all the peptides selected by the circular dichroism screening, only the ones that could be followed by fluorescence were tested for their lipid binding properties. 7.3 NUCLEAR MAGNETIC RESONANCE (NMR) This Example describes an NMR method for analyzing the structure of the core peptides of the invention. 7.3.1 NMR SAMPLE PREPARATION Samples were prepared by dissolving 5 mg of peptide in 90% H 2 O/10% D 2 0 containing trace amounts of 2 , 2-Dimethyl-2- εila-5-pentane sulfonate (DSS) as an internal chemical shift reference. Some of the samples contained trifluoroethanol (TFE) (expressed as % vol) . The total sample volume was 500 μl and the concentration of peptide was approximately 5 mM. 7.3.2 NMR SPECTROSCOPY X H NMR spectra were acquired at 500 MHz using a Bruker DRX500 spectrometer equipped with a B-VT2000 temperature control unit. One and two-dimensional experiments were recorded using standard pulse εequenceε. (Two Dimensional NMR Spectroscopy, Eds. W.R. Croasmun and RMK Carlson, 1994, VCH Publiεherε, New York, USA). Water εuppreεεion was achieved with low power presaturation for 2 sec. Two-dimensional experiments were carried out in the phase sensitive mode using time proportional phase incrementation (TPPI) and a spectral width of 6000 Hz in both dimensions. Typically, 40 scans were co-added for 400 increments with 2048 data points. Data were processed using FELIX95 software (Molecular Simulations) on an INDIG02 workstation (Silicon Graphics) . Data were zero-filled to give a 2K x 2K data matrix and apodized by a 45° shifted squared sine-bell function. 7.3.3 NMR ASSIGNMENT Complete proton resonance assignments were obtained by applying the sequential asεignment technique using DQFCOSY, TOCSY and NOESY εpectra aε described in the literature (Wύthrich, NMR of Proteins and Nucleic Acids, 1986, John Wiley & Sonε, New York, USA). Secondary chemical shifts were calculated for HN and Hα protons by subtracting the tabulated random coil chemical shifts (Wishart and Sykes, 1994, Method. Enz . 239:363-392) from the correεponding experimental valueε. 7.3.4 RESULTS AND DISCUSSION General Consideration. Amphipathic helical peptideε tend to aggregate in aqueous solutions at the high concentrations necessary for NMR spectroεcopy, making it difficult to obtain high resolution spectra. TFE is known to solubilize peptides, and in addition stabilizes helical conformations of peptideε having helical propenεity. The findings from NMR spectroscopy are demonstrated for peptide 210 (SEQ ID NO: 210) as a representative example. The consensus 22-mer of Segrest (SEQ ID NO: 75) was εtudied in compariεon. Secondary chemical shifts. Proton chemical shifts of amino acids depend both on the type of residue and on the local secondary structure within a peptide or protein (Szlagyi, 1995, Progresε in Nuclear Magnetic Reεonance Spectroεcopy 27:325-443). Therefore, identification of regular εecondary structure is possible by comparing experimental shifts with tabulated values for random coil conformation. Formation of an α-helix typically results in an up- field (negative) shift for the Hα resonance. Obεervation of an upfield Hα εhift for several sequential residueε is generally taken as evidence of a helical structure. The Hα secondary shifts for peptide 210 (SEQ ID NO: 210) in 25% TFE at 295 K show a significant negative shift for residues 4 through 15, demonstrating a highly helical conformation. Small differenceε are observed in the Hα chemical shifts of the consenεus 22-mer (SEQ ID NO: 75) compared to peptide 210 (SEQ ID NO:210) . The chemical shifts of amide hydrogens of amino acid reεidueε reεiding in regions of α-helix are also shifted upfield with respect to the chemical shifts observed for random coil. In addition, a periodicity of the HN shifts can be observed, and it reflects -the period of the helical turns. The amplitude of the εhift variation along the εequence iε related to the amphipathicity of a helical peptide. A higher hydrophobic moment leads to a more pronounced oscillation (Zhou et al., 1992, J. Am. Chem. Soc. 114:4320-4326). The HN secondary shifts for peptide 210 (SEQ ID NO: 210) in 25% TFE at 295 K show an oscillatory behavior in agreement with the amphipathic nature of the helix. The amino acid replacements lead to a more pronounced periodicity along the entire sequence. The pattern clearly reflects the stronger amphipathic nature of peptide 210 (SEQ ID NO: 210) as compared to Segrest' ε consensus 22-mer (SEQ ID NO: 75). The existence of 4-5 helical turns can be discerned. The secondary εhift of an amide proton iε influenced by the length of the hydrogen bond to the carbonyl oxygen one turn away from the helix. Therefore, the periodicity of obεerved chemical shift values reflects different hydrogen bond lengths. This difference is associated with an overall curved helical shape of the helix backbone. The hydrophobic residues are situated on the concave side. The secondary shifts of peptide 210 (SEQ ID NO: 210) indicate a curved α-helical conformation. 8 EXAMPLE: PHARMACOKINETICS OF THE APOA-I AGONISTS The following experiments can be used to demonstrate that the ApoA-I agoniεts are stable in the circulation and associate with the HDL component of plasma. 8.1 SYNTHESIS OF RADIOLABELLED PEPTIDES Radiolabelled peptides are synthesized by coupling a 14 C-labeled amino acid as the N-terminal amino acid. The syntheεis is carried out according to Lapatsaniε, Synthesis, 5 1983, 671-173. Briefly, 250 μM of unlabeled N-terminal amino acid is dissolved in 225 μl of a 9% Na 2 C0 3 solution and added to a solution (9% Na 2 C0 3 ) of 9.25 MBq (250 μM) 14 C-labeled N- terminal amino acid. The liquid is cooled down to 0°C, mixed with 600 μM (202 mg) 9-fluorenylmethyl-N- 0 succinimidylcarbonate (Fmoc-OSu) in 0.75 ml DMF and εhaken at room temperature for 4 hr. Thereafter the mixture is extracted with Diethylether (2 x 5ml) and chloroform (1 x 5ml) , the remaining aqueous phaεe iε acidified with 30% HC1 and extracted with chloroform (5 x 8 ml) . The organic phaεe 5 iε dried over Na 2 S0 4 , filtered off and the volume was reduced under nitrogen flow to 5 ml. The purity is estimated by TLC (CHCl 3 :MeOH:Hac, 9:1:0.1 v/v/v, εtationary phase RPTLC silicagel 60, Merck, Germany) . 0 8.2 PHARMACOKINETICS IN MICE In each experiment, 2.5 mg/kg radiolabelled peptide iε injected intraperitoneally into mice which are fed normal mouεe chow or the atherogenic Thomas-Harcroft modified diet (resulting in severely elevated VLDL and IDL choleεterol) . 5 Blood εamples are taken at multiple time intervals for asεeεεment of radioactivity in plasma. 8.3 STABILITY IN HUMAN SERUM The stability of the ApoA-I agonists of the 0 invention in human serum is demonstrated as described below. 8.3.1 EXPERIMENTAL METHODS 100 μg of 14 C-labeled peptide (prepared as described in Section 9.1, supra) , is mixed with 2 ml of fresh human 35 plasma (at 37 °C) and delipidated either immediately (control sample) or after 8 days of incubation at.37°C (test sample). Delipidation is carried out by extracting the lipids with an equal volume of 2 : 1 (v/v) chloroform:methanol. The samples are loaded onto a reverse-phase C18 HPLC column and eluted with a linear gradient (25-58% over 33 min.) of acetonitrile (containing 0.1% TFA) . Elution profiles are followed by absorbance (220 nm) and radioactivity. 8.4 FORMATION OF PRE-3 LIKE PARTICLES The ability of the ApoA-I agonists of the invention to form pre-/?-like particles is demonstrated as described below. 8.4.1 EXPERIMENTAL METHOD Human HDL is isolated by KBr density ultra centrifugation at density d= 1.21 g/ml to obtain top fraction followed by Superose 6 gel filtration chromatography to separate HDL from other lipoproteins. Isolated HDL iε adjusted to a final concentration of 1.0 g/ml with physiological saline based on protein content determined by Bradford protein asεay. An aliquot of 300 μl is removed from the isolated HDL preparation and incubated with 100 μl 14 C-labeled peptide for two hours at 37°C. Five separate incubations are analyzed including a blank containing 100 μl physiological saline and four dilutions of 14 C-labeled peptide: (i) 0.20 μg/μl peptide:HDL, ratio=l:15; (ii) 0.30 μg/μl peptide:HDL, ratio=l:10; (iii) 0.60 μg/μl peptide:HDL, ratio=l:5; and (iv) 1.00 μg/μl peptide:HDL, ratio=l:3. Following the two hour incubation, a 200 μl aliquot of the sample (total volume=400 μl) is loaded onto a Superose 6 gel filtration column for lipoprotein separation and analysiε, and 100 μl is used to determine total radioactivity loaded onto the column. 8.5 ASSOCIATION OF APO-A-I AGONISTS WITH HUMAN LIPOPROTEINS 8.5.1 EXPERIMENTAL METHODS The ability of the ApoA-I agonists of the invention to asεociate with human lipoprotein fractions is determined by incubating 14 C-labeled peptide with each lipoprotein claεε (HDL, LDL and VLDL) and a mixture of the different lipoprotein claεεes. HDIJ, LDL and VLDL are isolated by KBr density gradient ultracentrifugation at d=1.21 g/ml and purified by FPLC on a Superose 6B column εize excluεion column (chromatography iε carried out at a flow rate of 0.7 l/min. and a running buffer of 10 mM Triε (pH 8) , 115 mM NaCl, 2 mM EDTA and 0.01% NaN 3 ) . 14 C-labeled peptide iε incubated with HDL, LDL and VLDL at a peptide:phospholipid ratio of 1:5 (mass ratio) for 2 h at 37 °C. The required amount of lipoprotein (volumes based on amount needed to yield 1000 μg) is mixed with 0.2ml of peptide stock εolution (1 mg/ml) and the εolution iε brought up to 2.2 ml uεing 0.9% of NaCl. After incubating for 2 hr. at 37 °C, an aliquot (0.1 ml) is removed for liquid scintillation counting to determine the total radioactivity, the density of the remaining incubation mixture is adjusted to 1.21 g/ml with KBr, and the εampleε are centrifuged at 100,000 rpm (300,000 g) for 24 hourε at 4°C in a TLA 100.3 rotor uεing a Beckman tabletop ultracentrifuge. The reεulting supernatant is fractionated by removing 0.3 ml aliquots from the top of each sample for a total of 5 fractions, and 0.05 ml of each fraction is used for liquid scintillation counting. The top two fractions contain the floating lipoproteins, the other fractionε (3-5) correspond to proteins/peptides in solution. 8.6 THE ApoA-I AGONISTS OF THE INVENTION SELECTIVELY BIND HDL LIPIDS IN HUMAN PLASMA 8.6.1 EXPERIMENTAL METHOD To demonstrate that the ApoA-I agonists of the invention selectively bind HDL proteins in human plasma, 2 ml of human plasma is incubated with 20, 40, 60, 80, and 100 μg of 14 C-labeled peptide for 2 hr. at 37°C. The lipoproteins are separated by adjusting the density to 1.21 g/ml and centrifugation in a TLA 100.3 rotor at 100,000 rpm (300,000 0 g) for 36 hr. at 4°C. The top 900 μl (in 300 μl fractions) is taken for analysis. 50 μl from each 300 μl fraction is counted for radioactivity and 200 μl from each fraction iε analyzed by FPLC (Superose 6/Superose 12 combination column) . 5 9 EXAMPLE: THE ApoA-I AGONISTS PROMOTE CHOLESTEROL EFFLUX To demonstrate that the ApoA-I agonists of the invention promote cholesterol efflux, HepG hepatoma cells are plated into 6-well culture dishes and grown to confluence. Cells are labeled with 3 H-choleεterol by drying the 20 cholesterol, then adding 1% bovine serum albumin (BSA) in phosphate buffered εaline (PBS) , εonicating the solution, and adding 0.2 ml of this labeling solution and 1.8 ml growth medium to the cells, so that each well contains 2 μCi of radioactivity. Cells are incubated for 24 hr. with the _ 5 labeling medium. Peptide (or protein) :DMPC complexes are prepared at a 1:2 peptide (or protein) :DMPC ratio (w:w) . To prepare the complexes, peptide or native human ApoA-I protein is added to a DMPC solution in PBS and incubated at room temperature overnight, by which time the solution will clarify. Peptide or protein concentration in the final solution is about 1 mg/ml. Labeling media is removed from the cells and the cells are washed with PBS prior to addition of complexeε. _ 1.6 ml of growth medium iε added to each well, followed by peptide (or protein) :DMPC complex and sufficient PBS to bring the final volume to 2 ml per well. The final peptide or ApoA-I concentrations are about 1, 2.5, 5, 7.5 and 25 μg/ml medium. After 24 hours of incubation at 37 °C, the medium is removed, and the cells are washed with 2 ml of 1% BSA/PBS, followed by 2 washes with 2 ml each of PBS. The amount of 3 H- cholesterol effluxed into the medium is determined by liquid scintillation counting. 10 EXAMPLE: USE OF THE ApoA-I AGONISTS IN ANIMAL MODEL SYSTEMS The efficacy of the ApoA-I agonists of the invention was demonstrated in rabbits. The results show that administration of the ApoA-I agonistε increaεes serum concentration of HDL-like particles. 10.1 PREPARATION OF THE PHOSPHOLIPID/PEPTIDE COMPLEXES Small diεcoidal particles consiεting of phoεpholipid (DPPC) and peptide 146 (SEQ ID NO: 146) were prepared following the cholate dialyεis method. The phospholipid was disεolved in chloroform and dried under a εtream of nitrogen. The peptide was disεolved in buffer (saline) at a concentration of 1-2 mg/ml. The lipid film was redissolved in buffer containing cholate (43 °C) and the peptide solution was added at a 3-1 phoεpholipid/peptide ratio. The mixture was incubated overnight at 43 °C and then dialyzed at 43°C (24 hr.), room temperature (24 hr.) and 4°C (24 hr.), with three changes of buffer (large volumeε) at temperature point. The complexes were filter sterilized (0.22μ) for injection and storage at 4°C. 10.2 ISOLATION AND CHARACTERIZATION OF THE PEPTIDE/PHOSPHOLIPID PARTICLES The particles were separated on a gel filtration column (Superose 6 HR) . The position of the peak containing the particles was identified by measuring the phospholipid concentration in each fraction. From the elution volume, the Stokes radius can was determined. The concentration of peptide in the complex was determined by determining the phenylalanine content (by HPLC) following a 16 hr. acid hydrolysis. 10.3 INJECTION IN THE RABBIT Male New Zealand White rabbits (2.5-3 kg) were injected intravenouεly with a doεe of phospholipid/peptide complex (8 mg/kg bodyweight peptide 146 (SEQ ID NO: 146) or 10 mg/kg bodyweight ApoA-I, expressed as peptide or protein content) in a single bolus injection not exceeding 10-15 ml. The animals were εlightly εedated before the manipulationε. Blood εampleε (collected on EDTA) were taken before and 5, 15, 30, 60, 240 and 1440 minutes after injection. The hematocrit (Hct) was determined for each sample. Samples were aliquoted and stored at -20°C before analysiε. 10.4 ANALYSIS OF THE RABBIT SERA Plaεma Lipids. The total plasma cholesterol, plasma triglycerides and plasma phospholipids were determined enzymatically using commercially available asεays according to the manufacturer's protocols (Boehringer Mannheim, Mannheim, Germany and Biomerieux, 69280, Marcy-l'etoile, France) . Lipoprotein Profiles. The plasma lipoprotein profiles of the fractions obtained after the separation of the plasma into itε lipoprotein fractions were determined by spinning in a sucroεe denεity gradient. The fractions were collected and in each individual fraction the phospholipid and cholesterol content was meaεured enzymatically. 10.5 RESULTS The lipoprotein profile of rabbits injected with 8 mg/kg peptide 146 (SEQ ID NO: 146) (in the form of peptide/DPPC complexes) as a function of time. A substantial increase in cholesterol of the HDL cholesterol fractions (fractions >1.06 mg/ml) iε apparent at 5 min. following injection and lasts for approximately 24 hr. The cholesterol of the combined HDL fractions obtained by denεity gradient ultracentrifugation is presented in Table X, below. The highest increase of HDL cholesterol (90%) occurred 240 min. after administration. At 24 hr. following administration, the increase was still 71.2%. These data indicate that administration of peptide 146/DPPC complexes (8 mg/kg) induces rapid and efficient mobilization of peripheral cholesterol. TABLE X HDL CHOLESTEROL IN RABBITS FOLLOWING ADMINISTRATION OF 8 mg/kg 146 (SEQ ID NO: 146) or 10 mg/kg NATIVE ApoA-I Time (min.) Increase in HDL Increase in HDL Cholesterol (%) Cholesterol (%) Native ApoA-I Peptide 146 5 19.3 31.3 15 16 60.4 60 15.8 42.9 240 -24.1 90.2 1440 71.2 * animal died prior to time point 11 EXAMPLE: PREPARATION OF PEPTIDE-LIPID COMPLEX BY CO-LYOPHILIZATION APPROACH The following protocol was utilized to prepare peptide-lipid complexes. One mg of peptide 149 (PVLELFENLWERLLDALQKKLK; SEQ ID NO: 149) was dissolved in 250 μl HPLC grade methanol (Perkin Elmer) in a one ml clear glass vial with cap (Waters #WAT025054). Disεolving of the peptide was aided by occasional vortexing over a period of 10 minutes at room temperature. To this mixture an aliquot containing 3 mg dipalmitoyl-phosphatidyl-choline (DPPC; Avanti Polar Lipids, 99% Purity, product #850355) from a 100 mg/ml stock solution in methanol was added. The volume of the mixture was brought to 400 μl by addition of methanol, and the mixture was further vortexed intermittently for a period of 10 minutes at room temperature. To the tube 200 μl of xylene (Sigma- Aldrich 99% pure, HPLC-grade) was added and the tubes were vortexed for 10 seconds. Two small holes were punched into the top of the tube with a 20 gauge syringe needle, the tube waε frozen for 15 εecondε in liquid nitrogen, and the tube waε lyophilized overnight under vacuum. To the tube 200 mis of 0.9% NaCl solution was added. The tube was vortexed for 20 seconds. At this time the solution in the tube waε milky in appearance. The tube waε then incubated in a water bath for 30 minutes at 41°C. The solution became clear (i.e., similar to water in appearance) after a few minutes of incubation at 41°C. 11.1 CHARACTERIZATION OF COMPLEXES BY SUPEROSE 6 GEL FILTRATION CHROMATOGRAPHY Q Peptide-phoεpholipid complexes containing peptide 149 (SEQ ID NO: 149) were prepared by colyophilization as described above. The preparation contained 1 mg peptide and 3 mgs DPPC by weight. After reconstituting the complexes in 200 μl of 0.9% NaCl, 20μl (containing 100 μg peptide 149) of _ the complexes were applied to a Pharmacia Superose 6 column using 0.9% NaCl as the liquid phase at a flow rate of 0.5 mis/minute. The chromatography was monitored by absorbance or scattering of light of wavelength 280 nm. One ml fractions were collected. Aliquots containing 20 μl of the fractions were assayed for phospholipid content uεing the bioMerieux Phoεpholipideε Enzymatique PAP 150 kit (#61491) according to the inεtructionε supplied by the manufacturer. The vast majority of both phospholipid and UV absorbance were recovered together in a few fractions with peaks at approximately 15.8 mis. Thiε elution volume correεpondε to a Stokeε' diameter of 87 Angstroms. For comparison, a separate chromatogram of 20 μl of human HDL 2 was run under the same conditions and using the same column as the peptide 149 complexes. The HDL 2 was prepared aε follows: 300 mlε frozen human plasma (Mannheim Blutspendzentrale #1185190) was thawed, adjuεted to density 1.25 with solid potassium bromide, and centrifuged 45 hours at 40,000 RPM using a Ti45 rotor (Beck an) at 20°C. The floating layer was collected, dialyzed against distilled water, adjusted to density 1.07 with solid potassium bromide, and centrifuged as deεcribed above for 70 hour . The bottom layer (at a level of one cm above the tube bottom) was collected, brought to 0.01% sodium azide, and stored at 4°C for 4 days until chromatography. The column eluate was monitored by absorbance or scattering of light of wavelength 254 nm. A εeries of proteins of known molecular weight and Stokes' diameter were used aε εtandardε to calibrate the column for the calculation of Stokeε' diameterε of the particleε (Pharmacia Gel Filtration Calibration Kit Inεtruction Manual, Pharmacia Laboratory Separation, Piεcataway, NJ, reviεed April, 1985) . The HDL 2 eluted with a retention volume of 14.8 mlε, correεponding to a Stokeε' diameter of 108 nm. The preεent invention iε not to be limited in scope by the specific embodiments described herein. Indeed, variouε modificationε of the invention in addition to those described herein will become apparent to those skilled in the art from the foregoing deεcription and accompanying figures. Such modifications are intended to fall within the scope of the appended claimε. Various publications are cited herein, the diεcloεureε of which are incorporated by reference in their entiretieε. SEQUENCE LISTING (1) GENERAL INFORMATION (i) APPLICANT: Dasseux, Jean-Louis Sekul , Renate Buttner, Klaus Cornut, Isabelle Met2, Gunther Dufourcg, Jean (ii) TITLE OF THE INVENTION: GENE THERAPY APPROACHES TO SUPPLY APOLIPOPROTEIN A-I AGONISTS AND THEIR USE TO TREAT DYSLIPIDEMIC DISORDERS. (iii) NUMBER OF SEQUENCES: 270 (iv) CORRESPONDENCE ADDRESS: (A) ADDRESSEE: Pennie & Edmonds LLP (B) STREET: 1155 Avenue of the Americas (C) CITY: New York (D) STATE: NY (E) COUNTRY: USA (F) ZIP: 10036-2811 (v) COMPUTER READABLE FORM: (A) MEDIUM TYPE: Diskette (B) COMPUTER: IBM Compatible (C) OPERATING SYSTEM: DOS (D) SOFTWARE: FaεtSEQ Version 2.0 (vi) CURRENT APPLICATION DATA: (A) APPLICATION NUMBER: 08/940,136 (B) FILING DATE: 29-SEP-1997 (C) CLASSIFICATION: (vii) PRIOR APPLICATION DATA: (A) APPLICATION NUMBER: (B) FILING DATE: (viii ) ATTORNEY/AGENT INFORMATION : (A) NAME : Coruzzi , Laura A (B ) REGISTRATION NUMBER : 30 , 742 (C) REFERENCE /DOCKET NUMBER : 009196 - 0007 - 999 ( ix) TELECOMMUNICATION INFORMATION : (A) TELEPHONE: 650-493-4935 (B) TELEFAX: 650-493-5556 (C) TELEX: 66141 PENNIE (2) INFORMATION FOR SEQ ID NO:l: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS : single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 16 (D) OTHER INFORMATION: Xaa = Naphthylalanine (xi) SEQUENCE DESCRIPTION: SEQ ID NO : 1 : Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Xaa 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:2: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 amino acids (B) TYPE: amino acid (C) STRANDEDNESS : single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2: Gly Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys Lys 20 (2) INFORMATION FOR SEQ ID NO : 3 : (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO : 3 : Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Trp 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 4: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO : 4 : Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 5: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1 (D) OTHER INFORMATION: Xaa = D-Pro (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 5: Xaa Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys Lys 20 (2) INFORMATION FOR SEQ ID NO: 6: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO : 7 : (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7: Pro Val Leu Asp Leu Phe Lys Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO : 8 : (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 8: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Gly Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO : 9 : (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 9: Pro Val Leu Asp Leu Phe Arg Glu Leu Gly Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 10: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None ( i ) FEATURE : (A) NAME/KEY: Other (B) LOCATION: 17 (D) OTHER INFORMATION: Xaa = Naphthylalanine (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 10: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Xaa Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 11: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 11: Pro Val Leu Asp Leu Phe Lys Glu Leu Leu Gin Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 12: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Gly Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:13: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13: Gly Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Gly Leu Glu Ala 1 5 - 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 14: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 18 (D) OTHER INFORMATION: Xaa = Orn (A) NAME/KEY: Other (B) LOCATION: 20 (D) OTHER INFORMATION: Xaa = Orn (A) NAME/KEY: Other (B) LOCATION: 22 (D) OTHER INFORMATION: Xaa = Orn (xi) SEQUENCE DESCRIPTION: SEQ ID NO : 14 : Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 5 10 15 Leu Xaa Gin Xaa Leu Xaa 20 (2) INFORMATION FOR SEQ ID NO: 15: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 15: Pro Val Leu Asp Leu Phe Arg Glu Leu Trp Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 16: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO : 16 : Pro Val Leu Asp Leu Leu Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 17: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 17: Pro Val Leu Glu Leu Phe Lyε Glu Leu Leu Gin Glu Leu Leu Glu Ala 1 5 10 15 Leu Lyε Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 18: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:18: Gly Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 19: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1 (D) OTHER INFORMATION: Xaa = D-Pro (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 19: Xaa Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Gly Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 20: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 20: Pro Val Leu Asp Leu Phe Arg Glu Gly Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 • Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 21: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1 (D) OTHER INFORMATION: Xaa = D-Pro (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 21: Xaa Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:22: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 22: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Gly 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 23: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:23: Pro Leu Leu Glu Leu Phe Lys Glu Leu Leu Gin Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO:24: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 24: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 25: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO:25: Pro Val Leu Asp Phe Phe Arg Glu Leu Leu Asn Glu Xaa Leu Glu Ala 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:26: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Leu 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 27: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 14 (D) OTHER INFORMATION: Xaa = Naphthylalanine (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 27: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Xaa Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 28: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 28: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Trp Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 29: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUFNCE DESCRIPTION: SEQ ID NO: 29: Ala Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lyε Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 30: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...22 (D) OTHER INFORMATION: N-terminal dansylated peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 30: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 31: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 31: Pro Val Leu Asp Leu Phe Leu Glu Leu Leu Asn Glu Xaa Leu Glu A1E 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:32: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO:32: Xaa Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 33: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:33: Pro Val Leu Asp Leu Phe Arg Glu Lys Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 34: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS : single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 5 (D) OTHER INFORMATION: Xaa = Naphthylalanine (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 34: Pro Val Leu Asp Xaa Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 35: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 35: Pro Val Leu Asp Trp Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 is Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 36: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:36: Pro Leu Leu Glu Leu Leu Lys Glu Leu Leu Gin Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 37: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 37: Pro Val Leu Asp Leu Phe Arg Glu Trp Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO: 38: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 38: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Trp Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 39: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 39: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Glu Leu Leu Lys Ala 1 5 10 15 Leu Lys Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 40: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 40: Pro Val Leu Asp Leu Phe Asn Glu Leu Leu Arg Glu Leu Leu Glu Ala 1 5 10 is Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 41: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 41: Pro Val Leu Asp Leu Trp Arg Glu Leu Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 42: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 42: Pro Val Leu Asp Glu Phe Arg Glu Lyε Leu Asn Glu Xaa Trp Glu Ala 1 5 10 is Leu Lys Gin Lyε Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO:43: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO:43: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Trp Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 44: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...22 (D) OTHER INFORMATION: All genetically encoded amino acids are in the D-configuration (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 44: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 45: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 5: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:46: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46: Pro Val Leu Asp Leu Phe Arg Glu Lys Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 47: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 47: Val Leu Aεp Leu Phe Arg Glu Leu Leu Asn Glu Gly Leu Glu Ala Leu 1 5 10 15 Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 48: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1 (D) OTHER INFORMATION: Xaa = D-Pro (A) NAME/KEY: Other (B) LOCATION: 2 (D) OTHER INFORMATION: Xaa = D-Val (xi) SEQUENCE DESCRIPTION: SEQ ID NO:48: Xaa Xaa Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lyε Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 49: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None ( i) SEQUENCE DESCRIPTION: SEQ ID NO: 49: Pro Val Leu Asp Leu Phe Arg Asn Leu Leu Glu Lys Leu Leu Glu Ala 1 5 10 15 Leu Glu Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 50: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 50: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Trp Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 51: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 51: Pro Val Leu Asp Leu Phe Trp Glu Leu Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 52: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 52: Pro Val Trp Asp Glu Phe Arg Glu Lys Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:53: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:53: Val Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 54: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 54: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Trp Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 55: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 55: Pro Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala Leu Lys Gin 1 5 10 15 Lys Leu Lys (2) INFORMATION FOR SEQ ID NO: 56: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 56: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lyε Gin Lys Lys Lys 20 (2) INFORMATION FOR SEQ ID NO: 57: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 57: Pro Val Leu Asp Leu Phe Arg Asn Leu Leu Glu Glu Leu Leu Lys Ala 1 5 10 15 Leu Glu Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:58: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 58: u Ala (2) INFORMATION FOR SEQ ID NO: 59: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 59: Leu Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 60: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 60: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin (2) INFORMATION FOR SEQ ID NO: 61: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 61: Pro Val Leu Asp Glu Phe Arg Trp Lys Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 62: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO:62: Pro Val Leu Asp Glu Trp Arg Glu Lys Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 63: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO:63: Pro Val Leu Aεp Phe Phe Arg Glu Lys Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 64: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 64: Pro Trp Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:65: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 12 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO:65: Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Xaa Leu Glu Ala Leu 1 5 10 15 Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 66: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 66: Pro Val Leu Asp Leu Phe Arg Asn Leu Leu Glu Glu Leu Leu Glu Ala 1 5 10 15 Leu Gin Lyε Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 67: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 67: Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala Leu 1 5 10 15 Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 68: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 68: Pro Val Leu Asp Glu Phe Arg Glu Leu Leu Lys Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lyε Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO: 69: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 69: Pro Val Leu Asp Glu Phe Arg Lys Lys Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 70: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO:70: Pro Val Leu Asp Glu Phe Arg Glu Leu Leu Tyr Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lyε Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 71: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 14 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 71: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Leu Xaa Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 ( 2 ) INFORMATION FOR SEQ ID NO : 72 : ( i ) SEQUENCE CHARACTERISTICS : (A) LENGTH : 22 amino acids (B ) TYPE : amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 72: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Xaa Leu Trp Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 73: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 73: Pro Val Leu Asp Glu Phe Trp Glu Lyε Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 74: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 74 Pro Val Leu Asp Lys Phe Arg Glu Lys Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 ( 2 ) INFORMATION FOR SEQ ID NO : 75 : ( i ) SEQUENCE CHARACTERISTICS : (A) LENGTH : 22 amino acids (B) TYPE : amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 75: Pro Val Leu Asp Glu Phe Arg Glu Lyε Leu Asn Glu Glu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 76: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 76: Pro Val Leu Asp Glu Phe Arg Glu Leu Leu Phe Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 77: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 77: u Ala (2) INFORMATION FOR SEQ ID NO: 78: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 78: Pro Val Leu Asp Glu Phe Arg Asp Lys Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 79: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 79: Pro Val Leu Asp Glu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 80: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 80: Pro Val Leu Asp Leu Phe Glu Arg Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Gin Lys Lys Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO: 81: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO:81: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Trp Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 82: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 11 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 82: Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Xaa Leu Glu Ala Leu Lyε 1 5 10 15 Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 83: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO:83: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Trp Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 84: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 84: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 85: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 85: Pro Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala Leu 1 5 10 15 Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 86: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 86: Pro Val Leu Glu Leu Phe Glu Arg Leu Leu Asp Glu Leu Leu Asn Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID N0:87: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...22 (D) OTHER INFORMATION: All amino acids are in the D-configuration (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 87: Pro Leu Leu Glu Leu Leu Lys Glu Leu Leu Gin Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 88: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 88: Pro Val Leu Asp Lys Phe Arg Glu Leu Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO: 89: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 89: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Xaa Leu Trp Ala 1 5 10 15 Leu Lyε Gin Lyε Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO: 90: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 10 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 90: Asp Glu Phe Arg Glu Lys Leu Asn Glu Xaa Leu Glu Ala Leu Lys Gin 1 5 10 15 Lys Leu Lys (2) INFORMATION FOR SEQ ID NO: 91: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 91: Pro Val Leu Asp Glu Phe Arg Glu Leu Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 92: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 92: Pro Val Leu Asp Glu Phe Arg Glu Leu Tyr Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 93: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 93: ε Ala (2) INFORMATION FOR SEQ ID NO: 94: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 94: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Ala Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 95: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 95: Pro Val Leu Aεp Leu Phe Arg Glu Leu Leu Aεn Leu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 96: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...22 (D) OTHER INFORMATION: All genetically encoded amino acidε are in the D-configuration (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 96: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 97: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 97: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu 1 5 10 15 (2) INFORMATION FOR SEQ TD NO: 98: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 98: Pro Val Leu Aεp Leu Phe Arg Glu Leu Leu Asn Glu Glu Leu Glu Ala 1 5 10 15 Leu Lyε Gin Lyε Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO: 99: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 99: Lyε Leu Lys Gin Lys Leu Ala Glu Leu Leu Glu Asn Leu Leu Glu Arg 1 5 10 15 Phe Leu Asp Leu Val Pro 20 (2) INFORMATION FOR SEQ ID NO: 100: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...22 (D) OTHER INFORMATION: All amino acids are in the D-configuration (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 100: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2 ) INFORMATION FOR SEQ ID NO : 101 : ( i ) SEQUENCE CHARACTERISTICS : (A) LENGTH : 22 amino acids (B) TYPE : amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 101: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Trp Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 102: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 102: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Leu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Glu Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:103: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 103: u Ala (2) INFORMATION FOR SEQ ID NO:104: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 104: Pro Leu Leu Asn Glu Leu Leu Glu Ala Leu Lys Gin Lys Leu Lys 1 5 10 15 (2) INFORMATION FOR SEQ ID NO:105: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 105: Pro Ala Ala Asp Ala Phe Arg Glu Ala Ala Asn Glu Ala Ala Glu Ala 1 5 10 15 Ala Lys Gin Lys Ala Lys 20 (2) INFORMATION FOR SEQ ID NO:106: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 106: Pro Val Leu Aεp Leu Phe Arg Glu Lys Leu Asn Glu Glu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 107: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...22 (D) OTHER INFORMATION: All amino acids are in the D-configuration (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 107: Lys Leu Lys Gin Lys Leu Ala Glu Leu Leu Glu Asn Leu Leu Glu Arg 1 5 10 15 Phe Leu Asp Leu Val Pro 20 (2) INFORMATION FOR SEQ ID NO: 108: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 108: Pro Val Leu Asp Leu Phe Arg Trp Leu Leu Aεn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lyε Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 109: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 109: Pro Val Leu Asp Glu Phe Arg Glu Lyε Leu Asn Glu Arg Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 110: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (A) NAME/KEY: Other (B) LOCATION: 14 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 110: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Xaa Xaa Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 111: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 111: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Trp Glu Xaa Trp Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 112: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 112: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Xaa Ser Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 113: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 113: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Pro Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 114: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 114: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Xaa Met Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 115: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 115: Pro Lys Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 116: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 116: Pro Hiε Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lyε Gin Lyε Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO: 117: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 117: Pro Glu Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 118: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 13 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 118: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Xaa Leu Glu Ala 1 5 10 15 Leu Glu Gin Lyε Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO: 119: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 17 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 119: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Glu Leu Glu Ala 1 5 10 15 Xaa Lys Gin Lys Leu Lys 20 ( 2 ) INFORMATION FOR SEQ ID NO : 120 : ( i ) SEQUENCE CHARACTERISTICS : (A) LENGTH : 22 amino acids (B) TYPE : amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 16 (D) OTHER INFORMATION: Xaa = Aib (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 120: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Glu Leu Glu Xaa 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 121: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 121: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Glu Leu Glu Ala 1 5 10 15 Leu Trp Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 122: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 122: Pro Val Leu Asp Glu Phe Arg Glu Lys Leu Asn Glu Glu Leu Glu Trp 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:123: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:123: Gin Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 124: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 18 (D) OTHER INFORMATION: Xaa = Orn (A) NAME/KEY: Other (B) LOCATION: 20 (D) OTHER INFORMATION: Xaa = Orn (A) NAME/KEY: Other (B) LOCATION: 22 (D) OTHER INFORMATION: Xaa = Orn (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 124: Pro Val Leu Asp Leu Phe Xaa Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Xaa Gin Xaa Leu Xaa 20 (2) INFORMATION FOR SEQ ID NO: 125: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 125: Asn Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:126: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 126: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Gly Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 127: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 127: Pro Val Leu Aεp Leu Phe Arg Glu Leu Leu Aεn Glu Leu Leu Glu Leu 1 5 10 15 Leu Lys Gin Lyε Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 128: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 128: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Aεn Glu Leu Leu Glu Phe 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 129: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 129: Pro Val Leu Glu Leu Phe Aεn Aεp Leu Leu Arg Glu Leu Leu Glu Ala 1 ' 5 10 15 Leu Gin Lyε Lyε Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 130: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 130: Pro Val Leu Glu Leu Phe Asn Asp Leu Leu Arg Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:131: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 131: Pro Val Leu Glu Leu Phe Lyε Glu Leu Leu Aεn Glu Leu Leu Asp Ala 1 5 10 15 Leu Arg Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:132: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 132: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Asn Leu Leu Glu Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:133: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 133: Pro Val Leu Glu Leu Phe Glu Arg Leu Leu Glu Asp Leu Leu Gin Ala 1 5 10 15 Leu Asn Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:134: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:134: Pro Val Leu Glu Leu Phe Glu Arg Leu Leu Glu Asp Leu Leu Lys Ala 1 5 10 15 Leu Asn Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 135: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 135: Asp Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO: 136: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 136: Pro Ala Leu Glu Leu Phe Lys Asp Leu Leu Gin Glu Leu Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:137: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 17 (D) OTHER INFORMATION: Xaa = Naphthylalanine (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 137: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Gly Leu Glu Ala 1 5 10 15 Xaa Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 138: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 138: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Gly Leu Glu Trp 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 139: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 139: Pro Val Leu Asp Leu Phe Arg Glu Leu Trp Asn Glu Gly Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 140: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS : single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 18 (D) OTHER INFORMATION: Xaa = Orn (A) NAME/KEY: Other (B) LOCATION: 20 (D) OTHER INFORMATION: Xaa = Orn (A) NAME/KEY: Other (B) LOCATION: 22 (D) OTHER INFORMATION: Xaa = Orn (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 140 Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Gly Leu Glu Ala 1 5 10 15 Leu Xaa Gin Xaa Leu Xaa 20 (2) INFORMATION FOR SEQ ID NO: 141: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None ( i) SEQUENCE DESCRIPTION: SEQ ID NO: 141: Pro Val Leu Asp Phe Phe Arg Glu Leu Leu Asn Glu Gly Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO:142: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 142: Pro Val Leu Glu Leu Phe Arg Glu Leu Leu Asn Glu Gly Leu Glu Ala 1 5 10 15 Leu Lys Gin Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO : 143: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...22 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated peptide (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:143: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Gly Leu Glu Ala 1 5 10 15 Leu Lyε Gin Lyε Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO:144: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear ( ii) MOLECULE TYPE : None ( ix) FEATURE : (A) NAME/KEY: Other (B) LOCATION: 1 (D) OTHER INFORMATION: Xaa = D-Pro (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 144: Xaa Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 145: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 145: Gly Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:146: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 146: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 147: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 147: Pro Val Leu Glu Leu Phe Glu Aεn Leu Leu Glu Arg Leu Phe Aεp Ala 1 5 10 15 Leu Gin Lyε Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 148: (i) SEQUENCE CHARACTERISTICS : (A) LENGTH : 22 amino acids (B) TYPE : amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:148: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Gly Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 149: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS : single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 149: Pro Val Leu Glu Leu Phe Glu Asn Leu Trp Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lyε Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 150: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 150: Pro Leu Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Leu Aεp Ala 1 5 10 15 Leu Gin Lyε Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 151: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 151: Pro Val Leu Glu Leu Phe Glu Asn Leu Gly Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:152: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 152: Pro Val Phe Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 153: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 153: Ala Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 154: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 154: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Gly Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 155: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 155: Pro Val Leu Glu Leu Phe Leu Asn Leu Trp Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 156: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 156: Pro Val Leu Glu Leu Phe Leu Asn Leu Leu Glu Arg Leu Leu Asp Ala 1 5 ■ 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 157: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 157: Pro Val Leu Glu Phe Phe Glu Asn Leu Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 158: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:158: Pro Val Leu Glu Leu Phe Leu Asn Leu Leu Glu Arg Leu Leu Asp Trp 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 159: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 159: Pro Val Leu Aεp Leu Phe Glu Asn Leu Leu Glu Arg Leu Leu Asp Ala 1 5 10 is Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 160: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 160: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Leu Asp Trp 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 61: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS : single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:161: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Leu Glu Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 162: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:162: Pro Val Leu Glu Leu Phe Glu Asn Trp Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:163: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 163: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Trp Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:164: ( i ) SEQUENCE CHARACTERISTICS : (A) LENGTH : 22 amino acids (B) TYPE : amino acid (C) STRANDEDNESS : single (D) TOPOLOGY : linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 164: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Trp Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 165: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 165: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Leu Asp Leu 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:166: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 166: Pro Val Leu Glu Leu Phe Leu Aεn Leu Leu Glu Lyε Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO: 167: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 167: Pro Val Leu Glu Leu Phe Glu Asn Gly Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO:168: ( i) SEQUENCE CHARACTERISTICS : (A) LENGTH : 22 amino acids (B) TYPE : amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 168: Pro Val Leu Glu Leu Phe Glu Gin Leu Leu Glu Lys Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 169: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 169: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Lys Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 170: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 12 (D) OTHER INFORMATION: Xaa = Orn (A) NAME/KEY: Other (B) LOCATION: 19 (D) OTHER INFORMATION: Xaa = Orn (A) NAME/KEY: Other (B) LOCATION: 20 (D) OTHER INFORMATION: Xaa = Orn (A) NAME/KEY: Other (B) LOCATION: 22 (D) OTHER INFORMATION: Xaa = Orn (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 170: P p Ala Leu Gin Xaa Xaa Leu Xaa 20 (2) INFORMATION FOR SEQ ID NO: 171: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS : single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 171: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Lys Leu Leu Asp Leu 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:172: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 172: Pro Val Leu Glu Leu Phe Leu Aεn Leu Leu Glu Arg Leu Gly Aεp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:173: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 173: Pro Val Leu Asp Leu Phe Asp Asn Leu Leu Asp Arg Leu Leu Asp Leu 1 5 10 15 Leu Aεn Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 174: (i) SEQUENCE CHARACTERISTICS : (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...22 (D) OTHER INFORMATION: All amino acids are in the D-configuration ( i) SEQUENCE DESCRIPTION: SEQ ID NO: 174: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 175: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 175: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Leu Glu Leu 1 5 10 15 Leu Aεn Lyε Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 176: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 176: Pro Val Leu Glu Leu Trp Glu Aεn Leu Leu Glu Arg Leu Leu Aεp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 177: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:177: Gly Val Leu Glu Leu Phe Leu Asn Leu Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:178: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 178: Pro Val Leu Glu Leu Phe Asp Asn Leu Leu Glu Lys Leu Leu Glu Ala 1 5 10 15 Leu Gin Lys Lys Leu Arg 20 (2) INFORMATION FOR SEQ ID NO: 179: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:179: Pro Val Leu Glu Leu Phe Asp Asn Leu Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 180: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 180: Pro Val Leu Glu Leu Phe Asp Asn Leu Leu Asp Lys Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Arg 20 (2) INFORMATION FOR SEQ ID NO: 181: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 181: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Trp Leu Aεp Ala 1 5 10 15 Leu Gin Lyε Lyε Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO:182: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:182: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Lys Leu Leu Glu Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 183: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:183: Pro Leu Leu Glu Leu Phe Glu Asn Leu Leu Glu Lys Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 184: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 184: Pro Val Leu Glu Leu Phe Leu Asn Leu Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Trp Gin Lys Lys Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO: 185: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 19 (D) OTHER INFORMATION: Xaa = Orn (A) NAME/KEY: Other (B) LOCATION: 20 (D) OTHER INFORMATION: Xaa = Orn (A) NAME/KEY: Other (B) LOCATION: 22 (D) OTHER INFORMATION: Xaa = Orn (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 185: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Xaa Xaa Leu Xaa 20 (2) INFORMATION FOR SEQ ID NO: 186: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 186: Pro Val Leu Glu Leu Phe Glu Gin Leu Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 187: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:187: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Asn Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO:188: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 188: Pro Val Leu Glu Leu Phe Glu Asn Leu Leu Asp Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lyε 20 (2) INFORMATION FOR SEQ ID NO: 189: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 189: Asp Val Leu Glu Leu Phe Glu Asn Leu Leu Glu Arg Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Lys 20 (2) INFORMATION FOR SEQ ID NO: 190: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:190: Pro Val Leu Glu Phe Trp Asp Asn Leu Leu Asp Lys Leu Leu Asp Ala 1 5 10 15 Leu Gin Lys Lys Leu Arg 20 (2) INFORMATION FOR SEQ ID NO: 191: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 191: Pro Val Leu Aεp Leu Leu Arg Glu Leu Leu Glu Glu Leu Lys Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO:192: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 192: Pro Val Leu Asp Leu Phe Lys Glu Leu Leu Glu Glu Leu Lys Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 193: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 193: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Glu Leu Lys Gin Lyε 1 5 10 15 Leu Lyε (2) INFORMATION FOR SEQ ID NO: 194: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 194: Pro Val Leu Glu Leu Phe Arg Glu Leu Leu Glu Glu Leu Lyε Gin Lys 1 5 10 15 Leu Lyε (2) INFORMATION FOR SEQ ID NO: 195: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 195: Pro Val Leu Glu Leu Phe Lys Glu Leu Leu Glu Glu Leu Lys Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 196: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 196: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Glu Leu Lys Asn Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 197: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 197: Pro Leu Leu Asp Leu Phe Arg Glu Leu Leu Glu Glu Leu Lys Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 198: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated ( i) SEQUENCE DESCRIPTION: SEQ ID NO:198: Gly Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Glu Leu Lys Gin Lyε 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 199: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 199: Pro Val Leu Asp Leu Phe Arg Glu Leu Trp Glu Glu Leu Lys Gin Lys 1 5 10 15 Leu Lyε (2) INFORMATION FOR SEQ ID NO: 200: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 200: Asn Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Glu Leu Lys Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 201: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None ( ix) FEATURE : (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 201: Pro Leu Leu Asp Leu Phe Lys Glu Leu Leu Glu Glu Leu Lys Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 202: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 202: Pro Ala Leu Glu Leu Phe Lyε Aεp Leu Leu Glu Glu Leu Arg Gin Lys 1 5 10 15 Leu Arg (2) INFORMATION FOR SEQ ID NO: 03: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO:203: Ala Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Glu Leu Lys Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO:204: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS : εingle (D) TOPOLOGY: linear ( ii ) MOLECULE TYPE : None ( ix) FEATURE : (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 204: Pro Val Leu Asp Phe Phe Arg Glu Leu Leu Glu Glu Leu Lys Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 05: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 205: Pro Val Leu Asp Leu Phe Arg Glu Trp Leu Glu Glu Leu Lys Gin Lys 1 5 10 15 • Leu Lys (2) INFORMATION FOR SEQ ID NO: 206: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS : εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 206: Pro Leu Leu Glu Leu Leu Lys Glu Leu Leu Glu Glu Leu Lys Gin Lyε 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 207: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 207: Pro Val Leu Glu Leu Leu Lys Glu Leu Leu Glu Glu Leu Lys Gin Lys ' 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO:208: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO:208: Pro Ala Leu Glu Leu Phe Lyε Aεp Leu Leu Glu Glu Leu Arg Gin Arg 1 5 10 15 Leu Lyε (2) INFORMATION FOR SEQ ID NO: 209: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 209: Pro Val Leu Aεp Leu Phe Arg Glu Leu Leu Aεn Glu Leu Leu Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO:210: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:210: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Glu Leu Lys Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 211: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (A) NAME/KEY: Other (B) LOCATION: 14 (D) OTHER INFORMATION: Xaa = Orn (A) NAME/KEY: Other (B) LOCATION: 16 (D) OTHER INFORMATION: Xaa = Orn (A) NAME/KEY: Other (B) LOCATION: 18 (D) OTHER INFORMATION: Xaa = Orn (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 211: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Glu Leu Xaa Gin Xaa 1 5 10 15 Leu Xaa (2) INFORMATION FOR SEQ ID NO:212: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (A) NAME/KEY: Other (B) LOCATION: 7 (D) OTHER INFORMATION: Xaa = Orn (A) NAME/KEY: Other (B) LOCATION: 14 (D) OTHER INFORMATION: Xaa = Orn (A) NAME/KEY: Other (B) LOCATION: 16 (D) OTHER INFORMATION: Xaa = Orn (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 212: Pro Val Leu Asp Leu Phe Xaa Glu Leu Leu Glu Glu Leu Xaa Gin Xaa 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 213: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 213: Pro Ala Leu Glu Leu Phe Lyε Asp Leu Leu Glu Glu Phe Arg Gin Arg 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO:214: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (A) NAME/KEY: Other (B) LOCATION: 1 (D) OTHER INFORMATION: D-configuration of Pro (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 214: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Glu Leu Lys Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 215: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO:215: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Glu Trp Lys Gin Lys 1 5 10 15 Leu Lyε (2) INFORMATION FOR SEQ ID NO: 216: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:216: Pro Val Leu Glu Leu Phe Lyε Glu Leu Leu Glu Glu Leu Lyε Gin Lyε 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 217: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:217: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Leu Leu Lys Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO:218: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated ( i) SEQUENCE DESCRIPTION: SEQ ID NO:218: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Leu Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO-.219: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 219: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Trp Gin Lyε 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 220: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:220: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Glu Leu Gin Lys Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 221: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 221: Asp Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Glu Leu Lys Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO:222: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:222: Pro Val Leu Asp Ala Phe Arg Glu Leu Leu Glu Ala Leu Leu Gin Leu 1 5 10 15 Lys Lys (2) INFORMATION FOR SEQ ID NO: 223: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 223: Pro Val Leu Asp Ala Phe Arg Glu Leu Leu Glu Ala Leu Ala Gin Leu 1 5 10 15 Lys Lyε (2) INFORMATION FOR SEQ ID NO:224: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:224: Pro Val Leu Asp Leu Phe Arg Glu Gly Trp Glu Glu Leu Lys Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO:225: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:225: Pro Val Leu Asp Ala Phe Arg Glu Leu Ala Glu Ala Leu Ala Gin Leu 1 5 10 15 Lys Lys (2) INFORMATION FOR SEQ ID NO: 226: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 226: Pro Val Leu Asp Ala Phe Arg Glu Leu Gly Glu Ala Leu Leu Gin Leu 1 5 10 15 Lys Lys (2) INFORMATION FOR SEQ ID NO: 227: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 227: Pro Val Leu Asp Leu Phe Arg Glu Leu Gly Glu Glu Leu Lys Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO:228: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO:228: Pro Val Leu Asp Leu Phe Arg Glu Gly Leu Glu Glu Leu Lys Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 229: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear * (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO:229: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Glu Gly Lys Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 230: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 230: Pro Val Leu Glu Leu Phe Glu Arg Leu Leu Glu Aεp Leu Gin Lys Lyε 1 5 10 15 • Leu Lyε (2) INFORMATION FOR SEQ ID NO: 231: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 231: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Lys Leu Glu Gin Lys 1 5 10 15 Leu Lys (2) INFORMATION FOR SEQ ID NO: 232: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 232: Pro Leu Leu Glu Leu Phe Lys Glu Leu Leu Glu Glu Leu Lys Gin Lys 1 5 10 15 Leu Lyε (2) INFORMATION FOR SEQ ID NO: 233: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: (B) TYPE: (C) STRANDEDNESS: (D) TOPOLOGY: (ii) MOLECULE TYPE: (xi) SEQUENCE DESCRIPTION: SEQ ID NO:233: Thiε sequence has been intentionally εkipped (2) INFORMATION FOR SEQ ID NO: 234: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH : (B) TYPE: (C) STRANDEDNESS: (D) TOPOLOGY: (ii) MOLECULE TYPE: (xi) SEQUENCE DESCRIPTION: SEQ ID NO:234: Thiε sequence has been intentionally εkipped (2) INFORMATION FOR SEQ ID NO: 235: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH : (B) TYPE: (C) STRANDEDNESS: (D) TOPOLOGY: (ii) MOLECULE TYPE: (xi) SEQUENCE DESCRIPTION: SEQ ID NO:235: Thiε sequence has been intentionally skipped (2) INFORMATION FOR SEQ ID NO:236: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: (B) TYPE: (C) STRANDEDNESS: (D) TOPOLOGY: (ii) MOLECULE TYPE: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 236: This sequence has been intentionally skipped (2) INFORMATION FOR SEQ ID NO: 237: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:237: Leu Aεp Asp Leu Leu Gin Lyε Trp Ala Glu Ala Phe Asn Gin Leu Leu (2) INFORMATION FOR SEQ ID NO:238: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 238: Glu Trp Leu Lyε Ala Phe Tyr Glu Lyε Val Leu Glu Lyε Leu Lyε Glu 1 5 10 15 Leu Phe (2) INFORMATION FOR SEQ ID NO: 239: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 239: Glu (2) INFORMATION FOR SEQ ID NO: 240: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated ( i) SEQUENCE DESCRIPTION: SEQ ID NO : 240: Asp Trp Leu Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys Leu Lys Glu 1 5 10 15 Ala Phe (2) INFORMATION FOR SEQ ID NO: 241: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO : 241: Asp Trp Phe Lys Ala Phe Tyr Asp Lys Val Phe Glu Lys Phe Lys Glu 1 5 10 15 - Phe Phe (2) INFORMATION FOR SEQ ID NO: 242: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 242: Gly lie Lys Lys Phe Leu Gly Ser lie Trp Lys Phe lie Lyε Ala Phe 1 5 10 15 Val Gly (2) INFORMATION FOR SEQ ID NO:243: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 243: Asp Trp Phe Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys Phe Lys Glu 1 5 10 15 Ala Phe (2) INFORMATION FOR SEQ ID NO: 244: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:244: Asp Trp Leu Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys Leu Lys Glu 1 5 10 15 Ala Phe (2) INFORMATION FOR SEQ ID NO: 245: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 245: Asp Trp Leu Lys Ala Phe Tyr Asp Lyε Val Phe Glu Lyε Phe Lys Glu 1 5 10 15 Phe Phe (2) INFORMATION FOR SEQ ID NO: 246: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:246: Glu Trp Leu Glu Ala Phe Tyr Lys Lys Val Leu Glu Lys Leu Lyε Glu 1 5 10 15 Leu Phe (2) INFORMATION FOR SEQ ID NO:247: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:247: Asp Trp Phe Lys Ala Phe Tyr Asp Lys Phe Phe Glu Lys Phe Lys Glu 1 5 10 15 Phe Phe (2) INFORMATION FOR SEQ ID NO:248: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:248: Glu Trp Leu Lys Ala Phe Tyr Glu Lys Val Leu Glu Lys Leu Lys Glu 1 5 10 15 Leu Phe (2) INFORMATION FOR SEQ ID NO:249: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 249: Glu Trp Leu Lys Ala Glu Tyr Glu Lys Val Glu Glu Lys Leu Lys Glu 1 5 10 15 Leu Phe (2) INFORMATION FOR SEQ ID NO: 250: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 250: s Glu (2) INFORMATION FOR SEQ ID NO: 251: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...18 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 251: Glu Trp Leu Lys Ala Phe Tyr Lys Lys Val Leu Glu Lys Leu Lys Glu 1 5 10 15 Leu Phe (2) INFORMATION FOR SEQ ID NO: 252: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...15 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 252: Pro Val Leu Aεp Leu Phe Arg Glu Leu Leu Glu Gin Lyε Leu Lyε 1 5 10 15 (2) INFORMATION FOR SEQ ID NO:253: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...16 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO:253: P n Lys (2) INFORMATION FOR SEQ ID NO: 254: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...16 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO:254: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Lys Leu Lys Gin Lys 1 5 10 15 (2) INFORMATION FOR SEQ ID NO: 255: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...15 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 255: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Glu Lys Leu Gin Lys 1 5 10 15 (2) INFORMATION FOR SEQ ID NO: 256: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...16 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 256: Pro Val Leu Aεp Leu Phe Arg Glu Leu Leu Glu Ala Leu Lys Gin Lys 1 5 10 5 (2) INFORMATION FOR SEQ ID NO: 257: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...16 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 257: Pro Val Leu Asp Leu Phe Glu Asn Leu Leu Glu Arg Leu Lys Gin Lys 1 5 10 15 (2) INFORMATION FOR SEQ ID NO: 258: (i) SEQUENCE CHARACTERISTICS : (A) LENGTH: 16 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (ix) FEATURE: (A) NAME/KEY: Other (B) LOCATION: 1...16 (D) OTHER INFORMATION: N-terminal acetylated and C-terminal amidated (xi) SEQUENCE DESCRIPTION: SEQ ID NO:258: Pro Val Leu Asp Leu Phe Arg Glu Leu Leu Asn Glu Leu Lys Gin Lys 1 5 10 15 ■ (2) INFORMATION FOR SEQ ID NO: 259: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 842 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ix) FEATURE: (A) NAME/KEY: Coding Sequence (B) LOCATION: 1...801 (D) OTHER INFORMATION: (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 259: ATG AAA GCT GCG GTG CTG ACC TTG GCC GTG CTC TTC CTG ACG GGG AGC 48 Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 1 5 10 15 CAG GCT CGG CAT TTC TGG CAG CAA GAT GAA CCC CCC CAG AGC CCC TGG 96 Gin Ala Arg His Phe Trp Gin Gin Asp Glu Pro Pro Gin Ser Pro Trp 20 25 30 GAT CGA GTG AAG GAC CTG GCC ACT GTG TAC GTG GAT GTG CTC AAA GAC 144 Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Aεp Val Leu Lys Asp 35 40 45 AGC GGC AGA GAC TAT GTG TCC CAG TTT GAA GGC TCC GCC TTG GGA AAA 192 Ser Gly Arg Asp Tyr Val Ser Gin Phe Glu Gly Ser Ala Leu Gly Lys 50 55 60 CAG CTA AAC CTA AAG CTC CTT GAC AAC TGG GAC AGC GTG ACC TCC ACC 240 Gin Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 65 70 75 80 TTC AGC AAG CTG CGC GAA CAG CTC GGC CCT GTG ACC CAG GAG TTC TGG 288 Phe Ser Lys Leu Arg Glu Gin Leu Gly Pro Val Thr Gin Glu Phe Trp 85 90 95 GAT AAC CTG GAA AAG GAG ACA GAG GGC CTG AGG CAG GAG ATG AGC AAG 336 Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gin Glu Met Ser Lys 100 105 110 GAT CTG GAG GAG GTG AAG GCC AAG GTG CAG CCC TAC CTG GAC GAC TTC 384 Asp Leu Glu Glu Val Lys Ala Lys Val Gin Pro Tyr Leu Asp Asp Phe 115 120 125 CAG AAG AAG TGG CAG GAG GAG ATG GAG CTC TAC CGC CAG AAG GTG GAG 432 Gin Lys Lys Trp Gin Glu Glu Met Glu Leu Tyr Arg Gin Lys Val Glu 130 135 140 CCG CTG CGC GCA GAG CTC CAA GAG GGC GCG CGC CAG AAG CTG CAC GAG 480 Pro Leu Arg Ala Glu Leu Gin Glu Gly Ala Arg Gin Lys Leu His Glu 145 150 155 160 CTG CAA GAG AAG CTG AGC CCA CTG GGC GAG GAG ATG CGC GAC CGC GCG 528 Leu Gin Glu Lyε Leu Ser Pro Leu Gly Glu Glu Met Arg Aεp Arg Ala 165 170 175 CGC GCC CAT GTG GAC GCG CTG CGC ACG CAT CTG GCC CCC TAC AGC GAC 576 Arg Ala Hiε Val Aεp Ala Leu Arg Thr Hiε Leu Ala Pro Tyr Ser Aεp 180 185 190 GAG CTG CGC CAG CGC TTG GCC GCG CGC CTT GAG GCT CTC AAG GAG AAC 624 Glu Leu Arg Gin Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 195 200 205 GGC GGC GCC AGA CTG GCC GAG TAC CAC GCC AAG GCC ACC GAG CAT CTG 672 Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 210 215 220 AGC ACG CTC AGC GAG AAG GCC AAG CCC GCG CTC GAG GAC CTC CGC CAA 720 Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gin 225 230 235 240 GGC CTG CTG CCC GTG CTG GAG AGC TTC AAG GTC AGC TTC CTG AGC GCT 768 Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 245 250 255 CTC GAG GAG TAC ACT AAG AAG CTC AAC ACC CAG TGAGGCGCCC GCCGCCGCCC 821 Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gin 260 265 CCCTTCCCGG TGCTCAGAAT A 842 (2) INFORMATION FOR SEQ ID NO: 260: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 267 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (v) FRAGMENT TYPE: internal (xi) SEQUENCE DESCRIPTION: SEQ ID NO:260: Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 1 5 10 15 Gin Ala Arg Hiε Phe Trp Gin Gin Asp Glu Pro Pro Gin Ser Pro Trp 20 25 30 Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 35 40 45 Ser Gly Arg Asp Tyr Val Ser Gin Phe Glu Gly Ser Ala Leu Gly Lys 50 55 60 Gin Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 65 70 75 80 Phe Ser Lys Leu Arg Glu Gin Leu Gly Pro Val Thr Gin Glu Phe Trp 85 90 95 Asp Asn Leu Glu Lyε Glu Thr Glu Gly Leu Arg Gin Glu Met Ser Lyε 100 105 110 Asp Leu Glu Glu Val Lys Ala Lys Val Gin Pro Tyr Leu Asp Asp Phe 115 120 125 Gin Lys Lys Trp Gin Glu Glu Met Glu Leu Tyr Arg Gin Lys Val Glu 130 135 140 Pro Leu Arg Ala Glu Leu Gin Glu Gly Ala Arg Gin Lys Leu Hiε Glu 145 150 155 160 Leu Gin Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Aεp Arg Ala 165 170 175 Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 180 185 190 Glu Leu Arg Gin Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Aεn 195 200 205 Gly Gly Ala Arg Leu Ala Glu Tyr Hiε Ala Lyε Ala Thr Glu Hiε Leu 210 215 220 Ser Thr Leu Ser Glu Lyε Ala Lys Pro Ala Leu Glu Aεp Leu Arg Gin 225 230 235 240 Gly Leu Leu Pro Val Leu Glu Ser Phe Lyε Val Ser Phe Leu Ser Ala 245 250 255 Leu Glu Glu Tyr Thr Lyε Lyε Leu Aεn Thr Gin 260 265 (2) INFORMATION FOR SEQ ID NO: 261: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 66 baεe pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 261: CCTGTTCTTG ACCTCTTCCG TGAACTTCTT AACGAAGGCC TCGAGGCACT GAAACAGAAA 60 CTAAAA 6g (2) INFORMATION FOR SEQ ID NO:262: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 63 base pairε (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:262: GGTGTTCTGG ACCTCTTCCG TGAACTTCTT AACGAAGGCC TAGCGCTAAA ACAAAAACTA 60 AAA 63 (2) INFORMATION FOR SEQ ID NO:263: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 66 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:263: CCCGTGTTGG ACTTGTTCCG AGAACTACTA AACGAAGGAC TAGAATGGTT GAAACTAAAA 60 CTAAAA 66 (2) INFORMATION FOR SEQ ID NO: 264: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 66 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 264: GGTGTTTTGG AACTTTTCGA AAACTTATTG GAAAGATTGT TGGACGCACT GCAAAAAAAA 60 TTGAAA 66 (2) INFORMATION FOR SEQ ID NO: 265: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 66 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 265: CCAGTCTTGG AACTTTTCGA GAACTTGTGG GAGCGATTGT TGGATGCTTT GCAAAAAAAA 60 TTGAAA 66 (2) INFORMATION FOR SEQ ID NO: 266: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 66 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 266: GCCGTGTTGG AGCTGTTCGA AAACTTATTA GAGCGATTAT TAGACGCATT ACAGAAAAAA 60 TTGAAA 66 (2) INFORMATION FOR SEQ ID NO: 267: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 54 base pairε (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 267: CCTGTGTTGG ACTTGTTCCG CGAGTTATTA AACGAGTTAT TACAGAAATT AAAA 54 (2) IN70RMATI0N FOR SEQ ID NO:268: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 54 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:268: CCTGTGTTGG ACTTGTTGCG AGAATTATTA GAGGAATTAA AACAAAAACT AAAA 54 (2) INFORMATION FOR SEQ ID NO: 269: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 54 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 269: CCATTATTAG AATTATTTAA GGAATTATTG GAGGAGCTGG AACAGGAACT AGAA 54 (2) INFORMATION FOR SEQ ID NO: 270: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 270: Met Lyε Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 1 5 10 15 Gin Ala (2) INFORMATION FOR SEQ ID NO: 271: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:271: Met Lyε Ala Ala Val Leu Ala Val Ala Leu Val Phe Leu Thr Gly Cys 1 5 10 15 Gin Ala (2) INFORMATION FOR SEQ ID NO:272: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 6 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: εingle (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 272: Arg His Phe Trp Gin Gin 1 5 (2) INFORMATION FOR SEQ ID NO: 273: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 6 amino acidε (B) TYPE: amino acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: None (xi) SEQUENCE DESCRIPTION: SEQ ID NO:273: Xaa Glu Phe Xaa Gin Gin 1 5 (2) INFORMATION FOR SEQ ID NO:274: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:274: TGAACCCTTG ACCCCT 16

Claims: WHAT IS CLAIMED IS: 1. A nucleotide sequence encoding an ApoA-I agonist comprising: (i) a 15 to 29-residue peptide or peptide analogue which forms an amphipathic α-helix in the presence of lipids and which comprises the structural formula (I) : Xi-X 2 -X 3 -X,—X 5 —X 6 -X 7 —X 8 - 9 - 10 — ιι — X^— ^— α4 — 15 —X 1€ — 17 — lβ — 1S —X 20 —X^j-X 22 — 23 or a pharmaceutically acceptable salt thereof, wherein: X is Pro (P) , Ala (A) , Gly (G) , Gin (Q) , Asn (N) or Aεp (D) ; X 2 iε an aliphatic residue; X 3 is Leu (L) or Phe (F) ; X„ is an acidic residue; X 5 iε Leu (L) or Phe (F) ; X 6 is Leu (L) or Phe (F) ; X 7 is a hydrophilic residue; X 8 is an acidic or a basic residue; X 9 is Leu (L) or Gly (G) ; X 10 is Leu (L) , Trp (W) or Gly (G) ; X 3.3. is a hydrophilic residue; X 12 is a hydrophilic residue; X 13 is Gly (G) or an aliphatic residue; x i4 is Leu ( L ) / Tr P (W) or Gly (G) ; X 15 is a hydrophilic residue; X 16 is a hydrophobic residue; X 17 is a hydrophobic residue; X 18 is Gin (Q) , Asn (N) or a basic residue; X 19 is Gin (Q) , Asn (N) or a basic residue; X 20 iε a baεic residue; X 21 is an aliphatic residue; X 22 is a basic residue; X 23 is absent or a basic residue; or (ii) a deleted form of structural formula (I) in which at least one and up to eight of residues X x , X 2 , X 3 , X 4 , X 5 , X 6 , 7 "8/ "9 "10/ Xll# "l2 / l3 / l4 ' "15 I "16 / "17/ "18 "19 "20/ 21 and X 22 are deleted; or (iii) an altered form of εtructural formula (I) in which at least one of residues X lf X 2 , X 3 , X 4 , X 5 , X 6 , X 7 , X e , X 9 , X 10 , "11/ "12/ "13/ "14/ "15/ "16/ "17/ "18/ l9 / 20 / "21/ ^22 Or X 23 IS conservatively substituted with another residue. 2. The ApoA-I agonist encoded by the nucleotide sequence of Claim 1 which exhibits at least about 38% LCAT- activation activity as compared with human ApoA-I. 3. The ApoA-I agonist encoded by the nucleotide sequence of Claim 1 which is the altered form of structural formula (I) . 4. The ApoA-I agonist encoded by the nucleotide sequence of Claim 3 in which the hydrophobic residueε are fixed according to εtructural formula (I) and at least one non-fixed residue is conservatively substituted with another residue. 5. The ApoA-I agonist of Claim 4 in which: X x is Pro (P) , Gly (G) or Ala (A) ; X 2 is Ala (A) , Leu (L) or Val (V) ; X 3 is Leu (L) or Phe (F) ; X 5 is Leu (L) or Phe (F) ; X 6 is Leu (L) or Phe (F) ; X 9 is Leu (L) or Gly (G) ; χ 10 is Leu (L) , Trp (W) or Gly (G) ; X 13 is Leu (L) or Gly (G) ; X 14 is Leu (L) , Trp (W) or Gly (G) ; X 16 is Ala (A) , Trp (W) , Gly (G) , Leu (L) or Phe ( F) ; X 17 iε Leu (L) or Gly (G) ; X 21 is Leu (L) ; and at least one of X 4 , X 7 , X 8 , X12/ X 1 5/ "ιβ/ " 1 9/ X 2 0 " 22 and X 23 is conservatively substituted with another residue. 6. The ApoA-I agonist of Claim 3 in which the hydrophilic residueε are fixed according to structural formula (I) and at least one non-fixed residue is conservatively subεtituted with another reεidue. 7. The ApoA-I agoniεt of Claim 6 in which: X 4 is Asp (D) or Glu (E) ; X 7 iε Lys (K) or Arg (R) ; X 8 is Asp (D) or Glu (E) ; X l is Asn (N) or Gin (Q) ; X 12 is Glu (E) or Asp (D) ; X 15 iε Aεp (D) or Glu (E) ; X 18 is Gin (Q) , Asn (N) or Lys (K) ; X 19 is Gin (Q) , Asn (N) or Lys (K) ; X 20 is Lyε (K); X 22 is Lys (K) ; X 23 is absent or Lys (K) ; and at leaεt one of X lf X 2 , X 3; X 5 , X 6 , X 5 , X 10 , X 13 , X 3.4 , Xη .6/ χ i 7 and X 21 iε conservatively substituted with another residue. 8. The ApoA-I agonist of Claim 7 in which X 3 is Leu (L) or Phe (F) , X 6 is Phe (F) , X 9 is Leu (L) or Gly (G) , X 10 iε Leu (L) or Trp (W) or Gly (G) and at leaεt one of X l t X 2 , X 5 , X 13 , x i 4 / χ i 6 x i7 and χ 2 i i conservatively substituted with another residue. 9. The ApoA-I agoniεt of Claim 5 or 7 in which the substituting reεidue iε classified within the same sub- category as the substituted residue. 10. The ApoA-I agoniεt encoded by the nucleotide sequence of Claim 1 which is the deleted form of εtructural formula (I) . 11. The ApoA-I agonist of Claim 10 in which one helical turn of the peptide or peptide analogue is deleted. 12. The ApoA-I agonist encoded by the nucleotide sequence of Claim 1 which is a 22-23 residue peptide or peptide analogue of structural formula (I) . 13. The ApoA-I agonist encoded by the nucleotide sequence of Claim 1, in which: X 1 iε Pro (P) , Ala (A) , Gly (G) , Aεn (N) , Gin (Q) or Aεp (D) ; X 2 iε Ala (A) , Val (V) or Leu (L) ; X 3 iε Leu (L) or Phe (F) X 4 is Asp (D) or Glu (E) X 5 iε Leu (L) or Phe (F) X 6 iε Leu (L) or Phe (F) X 7 iε Lys (K) or Arg (R) X 8 is Asp (D) or Glu (E) X s is Leu (L) or Gly (G) X 10 is Leu (L) , Trp (W) or Gly (G) ; X 1X is Aεn (N) or Gin (Q) ; X, is Glu (E) or Asp (D) ; X 13 is Gly (G) or Leu (L) ; X 14 iε Leu (L) Trp (W) or Gly (G) ; X ιε iε Aεp (D) or Glu (E) ; X 16 iε Ala (A) , Trp (W) , Leu (L) , Phe (F) or Gly (G); X 17 is Gly (G) or Leu (L) ; X 18 is Gin (Q) , Asn (N) or Lyε (K) ; X 19 iε Gin (Q) , Aεn (N) or Lys (K) ; X 20 is Lyε (K) ; X 21 iε Leu (L) ; X 22 is Lys (K) ; and X 23 is absent or Lys (K) . 14, The ApoA-I agoniεt of Claim 13 , in which X 23 iε absent. 15. The ApoA-I agonist of Claim 13, in which one of X 1B or X 19 is Gin (Q) or Asn (N) and the other of X 18 or X 19 is Lyε (K). 16. The ApoA-I agonist of Claim 13 in which each of X 9 , X 10 , X 13 , X 14 , X 15 and X 17 is other than Gly (G) . 17. The ApoA-I agonist of Claim 13 in which one of X 9 , X 10 , X 13 , X 14 , X 15 and X 17 iε Gly (G) and the otherε are other than Gly (G) . 18. The nucleotide εequence of Claim 1 which encodeε an ApoA-I agoniεt having an amino acid εequence selected from the group consiεting of: peptide 2 GVLDLFRELLNELLEALKQKLKK (SEQ ID NO: 2) peptide 3 PVLDLFRELLNELLEWLKQKLK (SEQ ID NO: 3) peptide 4 PVLDLFRELLNELLEALKQKLK (SEQ ID NO: 4) peptide 7 PVLDLFRELLNELLEALKQKLK (SEQ ID NO: 7) peptide 8 PVLDLFRELLNEGLEALKQKLK (SEQ ID NO:8) peptide 9 PVLDLFRELGNELLEALKQKLK (SEQ ID NO: 9) peptide 11 PVLDLFKELLQELLEALKQKLK (SEQ ID NO: 11 peptide 12 PVLDLFRELLNELLEAGKQKLK (SEQ ID NO: 12 peptide 13 GVLDLFRELLNEGLEALKQKLK (SEQ ID NO: 13 peptide 15 PVLDLFRELWNELLEALKQKLK (SEQ ID NO: 15 peptide 16 PVLDLLRELLNELLEALKQKLK (SEQ ID NO:16 peptide 17 PVLELFKELLQELLEALKQKLK (SEQ ID NO: 17 peptide 18 GVLDLFRELLNELLEALKQKLK (SEQ ID NO: 18 peptide 20 PVLDLFREGLNELLEALKQKLK (SEQ ID NO:20 peptide 22 PVLDLFRELLNELLEGLKQKLK (SEQ ID NO:22 peptide 23 PLLELFKELLQELLEALKQKLK (SEQ ID NO:23 peptide 24 PVLDLFRELLNELLEALQKKLK (SEQ ID NO:24 peptide 26 PVLDLFRELLNELLELLKQKLK (SEQ ID NO:26 peptide 28 PVLDLFRELLNELWEALKQKLK (SEQ ID NO:28 peptide 29 AVLDLFRELLNELLEALKQKLK (SEQ ID NO:29 peptide 123 QVLDLFRELLNELLEALKQKLK (SEQ ID NO: 123) peptide 125 NVLDLFRELLNELLEALKQKLK (SEQ ID NO: 125) peptide 126 PVLDLFRELLNELGEALKQKLK (SEQ ID NO: 126) peptide 127 PVLDLFRELLNELLELLKQKLK (SEQ ID NO: 127) peptide 128 PVLDLFRELLNELLEFLKQKLK (SEQ ID NO: 128) peptide 129 PVLELFNDLLRELLEALQKKLK (SEQ ID NO: 129) peptide 130 PVLELFNDLLRELLEALKQKLK (SEQ ID NO: 130) peptide 131 PVLELFKELLNELLDALRQKLK (SEQ ID NO: 131) peptide 132 PVLDLFRELLENLLEALQKKLK (SEQ ID NO: 132) peptide 133 PVLELFERLLEDLLQALNKKLK (SEQ ID NO: 133) peptide 134 PVLELFERLLEDLLKALNQKLK (SEQ ID NO: 134) peptide 135 DVLDLFRELLNELLEALKQKLK (SEQ ID NO: 135) peptide 136 PALELFKDLLQELLEALKQKLK (SEQ ID NO: 136) peptide 138 PVLDLFRELLNEGLEWLKQKLK (SEQ ID NO: 138) peptide 139 PVLDLFRELWNEGLEALKQKLK (SEQ ID NO: 139) peptide 141 PVLDFFRELLNEGLEALKQKLK (SEQ ID NO: 141) or peptide 142 PVLELFRELLNEGLEALKQKLK (SEQ ID NO: 142) 19. A nucleotide sequence encoding an ApoA-I agonist comprising: (i) a 15 to 29-residue peptide or peptide analogue which forms an amphipathic α-helix in the presence of lipids and which comprises the structural formula (II) : Xj- X 2 _ Xj— X 4 — X 5 — X £ — X 7 — X 8 — X 9 — X 10 X ll - X l2 X-3 — l — - 5 X_ 6 * 17 X l 8 — X-9 . 0 — ^ 21 ~^ 22 _ "23 or a pharmaceutically acceptable salt thereof, wherein: X 1 is Pro (P) , Ala (A) , Gly (G) , Gin (Q) , Asn (N) or Asp (D) ; X, iε an aliphatic reεidue Val (v) or Len(L); iε Leu (L) or Phe (F) ; X 4 is Glu (E) ; X, is an aliphatic residue: χ 6 is Leu (L) or Phe (F) ; *7 iε Glu (E) or Leu (L) ; x. is Asn (N) or Gin (Q) ; X 9 is Leu (L) ; X 10 is Leu (L) , Trp (W) or Gly (G) ; X u is an acidic residue; X 12 is Arg (R) ; X 13 is Leu (L) or Gly (G) ; X 14 is Leu (L) , Phe (F) or Gly (G) ; X 15 is Asp (D) ; X 16 is Ala (A) ; X 17 is Leu (L) ; X 18 iε Aεn (N) or Gin (Q) ; X 19 iε a baεic residue ; X 20 is a basic reεidue ; X 21 is Leu (L) ; X 22 is a basic reεidue; X 23 iε abεent or a baεic residue; or (ii) a deleted form of εtructural formula (II) in which at leaεt one and up to eight of residues X x , X 2 , X 3 , X 4 , X 5 , X 6 , "7/ "8/ "9/ "10/ "11/ "12/ "13/ "l4 / "15/ "l6 / "17/ "lB / ^19 "20/ "21 and X 22 are deleted; or (iii) an altered form of εtructural formula (II) in which at leaεt one of reεidueε X 1( X 2 , X 3 , X 4 , X 5 , X 6 , X 7 , X 8 , "9/ XlO/ "11/ l2 / "13/ "14/ "15/ "16/ "17/ "18/ "19/ X 2 0 / "21/ "22 Or X 23 iε conservatively substituted with another residue. 20. The ApoA-I agonist encoded by the nucleotide sequence of Claim 18 which exhibits at leaεt about 38% LCAT- activation activity as compared with human ApoA-I. 21. The ApoA-I agonist encoded by the nucleotide sequence of Claim 18 which is the altered form of εtructural formula (II) . 22. The ApoA-I agonist of Claim 20 in which the hydrophobic residues are fixed according to structural formula (II) and at least one non-fixed residue iε conservatively subεtituted with another residue. 23. The ApoA-I agoniεt of Claim 21 in which: X 1 iε Pro (P) , Gly (G) , Aεn (N) or Ala (A) ; X 2 is Ala (A) , Leu (L) or Val (V) ; X 3 is Leu (L) or Phe (F) ; X 5 is Leu (L) ; X ε is Phe (F) ; X 9 is Leu (L) ; X 10 is Leu (L) , Trp (W) or Gly (G) ; X 13 iε Leu (L) or Gly (G) ; X 14 iε Leu (L) , Phe (F) or Gly (G) ; X 16 iε Ala (A) ; X 17 iε Leu (L) ; X 21 iε Leu (L) ; and at leaεt one of X 4 , X 7 , X 8 , X llf X 12 , X 15 , X 18 , X 19 , X 22 and X 23 is conservatively substituted with another residue. 24. The ApoA-I agonist encoded by the nucleotide sequence of Claim 20 in which the hydrophilic residueε are fixed according to εtructural formula (II) and at leaεt one non-fixed reεidue is conservatively substituted with another reεidue. 25. The ApoA-I agonist of Claim 23 in which: X 4 is Glu (E) ; X 7 is Glu (E) ; X 8 is Asn (N) or Gin (Q) ; X X1 is Asp (D) or Glu (E) ; X 12 is Arg (R) ; X 15 is Asp (D) ; X 18 is Asn (N) or Gin (Q) ; X 19 is Lys (K); X 20 iε Lys (K); X 22 is Lyε (K) ; X 23 iε abεent or Lyε (K) ; and at least one of X x , X 2 , X 3 , X 5 , X 6 , X 9 , X ± o , X 13 , X 3.4 , " 16 " 17 and X 21 is conservatively subεtituted with another reεidue. 26. The ApoA-I agoniεt of Claim 23 in which X 3 iε Leu (L) or Phe (F) , X 6 iε Phe (F) , X 9 is Leu (L) , X 10 is Leu (L) , Trp (W) or Gly (G) and at least one of X lf X 2 , X 5 , X 13 , X 14 , X 16 , X 17 and X 21 is conεervatively εubstituted with another residue. 27. The ApoA-I agonist of Claim 22 or 24 in which the εubstituting residue is claεεified within the same sub- category aε the substituted residue. 28. The ApoA-I agonist encoded by the nucleotide sequence of Claim 18 which iε the deleted form of structural formula (II) . 29. The ApoA-I agonist of Claim 27 in which one helical turn of the peptide or peptide analogue is deleted. 30. The ApoA-I agonist encoded by the nucleotide sequence of Claim 18 which is a 22-23 residue peptide or peptide analogue of structural formula (II) . 31. The ApoA-I agonist encoded by the nucleotide εequence of Claim 18, in which: Xi is Pro (P) , Ala (A) , Gly (G) or Asn (N) ; X 2 is Ala (A) , Val (V) or Leu (L) ; X 3 is Leu (L) or Phe (F) ; X 4 is Glu (E) X 5 iε Leu (L) X 6 is Phe (F) X 7 is Leu (L) or Glu (E) ; X 8 is Asn (N) or Gin (Q) ; X 9 is Leu (L) ; X 10 is Leu (L) , Trp (W) or Gly (G) ; X X1 iε Glu (E) ; X 12 is Arg (R) ; *13 is Leu (L) or Gly (G) ; "14 is Leu (L) , Phe ( F) or Gly (G) ; "17 iε Leu (L) ; X 19 iε Lyε (K) X 20 iε Lys (K) X 21 is Leu (L) X 22 is Lyε (K) and X 23 iε abεent or Lyε (K) . 32. The ApoA-I agσniεt of Claim 30, in which X 23 iε absent. 33. The ApoA-I agoniεt of Claim 30, in which each of X 10 , X 13 and X 14 iε other than Gly (G) . 34. The ApoA-I agoniεt of Claim 31, in which one of X 10 , X 13 or X 14 iε Gly (G) and the otherε are other than Gly (G) . 35. The nucleotide sequence of Claim 18 which encodes an ApoA-I agoniεt having an amino acid sequence selected from the group conεiεting of: (SEQ ID NO: 145) GVLELFENLLERLLDALQKKLK; (SEQ ID NO: 146) PVLELFENLLERLLDALQKKLK; (SEQ ID NO: 147) PVLELFENLLERLFDALQKKLK; (SEQ ID NO: 148) PVLELFENLLERLGDALQKKLK; (SEQ ID NO: 149) PVLELFENLWERLLDALQKKLK; (SEQ ID NO: 150) PLLELFENLLERLLDALQKKLK; (SEQ ID NO: 151) PVLELFENLGERLLDALQKKLK; (SEQ ID NO: 152) PVFELFENLLERLLDALQKKLK; (SEQ ID NO: :153) AVLELFENLLERLLDALQKKLK; (SEQ ID NO: ;154) PVLELFENLLERGLDALQKKLK; (SEQ ID NO: :155) PVLELFLNLWERLLDALQKKLK; (SEQ ID NO :186) PVLELFEQLLERLLDALQKKLK; (SEQ ID NO: 187) PVLELFENLLERLLDALNKKLK; (SEQ ID NO: 188) PVLELFENLLDRLLDALQKKLK; or (SEQ ID NO: 189) DVLELFENLLERLLDALQKKLK. 36. A nucleotide sequence encoding an ApoA-I agonist comprising: (i) a 14 to 22-residue peptide or peptide analogue which forms an amphipathic α-helix in the presence of lipids and which comprises the structural formula (III) : Xi-X 2 —X 3 -X 4 —X 5 -X 6 -X 7 —X 8 —X 9 -X 10 —X 11 -X 12 —X 13 —X 14 —X 15 —X 16 —X 17 —X 18 X 1 is Pro (P) , Ala (A) , Gly (G) , Asn (N) or Gin (Q) ; X 2 is an aliphatic amino acid; X 3 is Leu (L) ; X 4 is an acidic amino acid; X 5 is Leu (L) or Phe (F) ; X 6 is Leu (L) or Phe (F) ; X 7 is a basic amino acid; X 8 is an acidic amino acid; X 9 is Leu (L) or Trp (W) ; X 10 is Leu (L) or Trp (W) ; X lx is an acidic amino acid or Asn (N) ; X 12 is an acidic amino acid; X 13 is Leu (L) , Trp (W) or Phe (F) ; X 14 is a basic amino acid or Leu (L) ; X 15 is Gin (Q) or Asn (N) ; X 16 is a basic amino acid; X 17 iε Leu (L) ; X 18 iε a baεic amino acid; (ii) a deleted form of structural formula (III) in which at least one and up to eight of residueε X ι r X 2 , X 3 , X 4 , X 5 , X 6 , "7 / "8 / "9 / "10 / "11 / "12 / "13 / "14 / "l5 / "16 / "17 ^nd X 18 Sf β deleted ; or (iii) an altered form of structural formula (III) in which at least one of residueε X lf X 2 , X 3 , X 4 , X 5 , X 6 , X 7 , X 8 , X 9 , X 10 , X llf X 12 , X 13 , X 14 , X 15 , X 16 , X 17 or X 18 is conservatively substituted with another residue. 37. The ApoA-I agonist encoded by the nucleotide sequence of Claim 36 which exhioits at least about 38% LCAT- activation activity as compared with human ApoA-I. 38. The ApoA-I agonist encoded by the nucleotide εequence of Claim 36 which iε the altered form of εtructural formula (III) . 39. The ApoA-I agoniεt of Claim 38 in which the hydrophobic residues are fixed according to structural formula (III) and at least one non-fixed residue is conservatively εubεtituted with another reεidue. 40. The ApoA-I agoniεt of Claim 39 in which: X- L iε Pro (P) , Gly (G) , Aεn (N) or Ala (A) ; X 2 is Ala (A) , Leu (L) or Val (V) ; X 3 is Leu (L) ; X 5 iε Leu (L) or Phe (F) ; X 6 iε Leu (L) or Phe (F) ; X 10 iε Leu (L) or Trp (W) ; X 13 iε Leu (L) , Trp (W) or Phe (F) ; X 17 is Leu (L) ; and at least one of X 4 , X 7 , X 8 , X 1X , X 12 , X 14 , X 15 , X 16 and X 18 iε conεervatively εubεtituted with another reεidue. 41. The ApoA-I agonist of Claim 38 in which the hydrophilic residueε are fixed according to structural formula (III) and at least one non-fixed residue is conεervatively εubεtituted with another residue. 42. The ApoA-I agonist of Claim 41 in which: X 4 is Aεp (D) or Glu (E) ; X 7 is Arg (R) or Lys (K) ; X 8 is Asp (D) or Glu (E) ; X ιτ is Asn (N) or Glu (E) ; X 12 iε Glu (E) ; X 14 is Lys (K) or Arg (R) ; X 15 is Gin (Q) or Asn (N) ; X α6 is Lys (K) or Arg (R) ; X 18 is Asn (N) or Gin (Q) ; and at least one of X l t X 2 , X 3 , X 5 , X 6 , X 9 , X 10 , X 13 and X 17 is conservatively subεtituted with another residue. 43. The ApoA-I agonist of Claim 41 in which X 3 is Leu (L) , X 6 is Phe (F) , X 9 is Leu (L) or Trp (W) , X 10 is Leu (L) or Trp (W) and at least one of X lf X 2 , X 5 , X 13 and X 17 is conservatively substituted with another residue. 44. The ApoA-I agonist of Claim 40 or 42 in which the εubεtituting residue is clasεified within the εame εub- category aε the subεtituted residue. 45. The ApoA-I agonist of Claim 36 which is the deleted form of structural formula (III) . 46. The ApoA-I agonist of Claim 45 in which one helical turn of the peptide or peptide analogue is deleted. 47. The ApoA-I agonist of Claim 36 which is an 18- residue peptide or peptide analogue of structural formula (III). 48. The ApoA-I agonist encoded by the nucleotide sequence of Claim 36, in which: X 1 is Pro (P) , Ala (A) , Gly (G) or Asn (N) ; X 2 is Ala (A) , Val (V) or Leu (L) ; X 3 is Leu (L) ; X 4 is Aεp (D) or Glu (E) ; X 5 is Leu (L) or Phe (F) X 6 iε Leu (L) or Phe (F) X 7 is Arg (R) or Lys (K) X 8 iε Aεp (D) or Glu (E) X 9 iε Leu (L) or Trp (W) X 10 is Leu (L) or Trp (W) ; X xl is Glu (E) or Asn (N) ; X i2 is Glu (£); X 13 is Leu (L) , Trp (W) or Phe (F) ; X 14 iε Arg (R) or Lys (K) ; X 15 iε Gin (Q) or Asn (N) ; X 16 iε Arg (R) or Lyε (K) ; X 17 iε Leu (L) ; and X 18 iε Arg (R) or Lyε (K) . 49. The nucleotide sequence of Claim 36 which encodes an ApoA-I agoniεt having an amino acid sequence selected from the group consisting of: peptide 191 PVLDLLRELLEELKQKLK* (SEQ ID NO: 191) peptide 192 PVLDLFKELLEELKQKLK* (SEQ ID NO:192) peptide 193 PVLDLFRELLEELKQKLK* (SEQ ID NO:193) peptide 194 PVLELFRELLEELKQKLK* (SEQ ID NO:194) peptide 195 PVLELFKELLEELKQKLK* (SEQ ID NO: 195) peptide 196 PVLDLFRELLEELKNKLK* (SEQ ID NO:196) peptide 197 PLLDLFRELLEELKQKLK* (SEQ ID NO: 197) peptide 198 GVLDLFRELLEELKQKLK* (SEQ ID NO:198) peptide 199 PVLDLFRELWEELKQKLK* (SEQ ID NO:199) peptide 200 NVLDLFRELLEELKQKLK* (SEQ ID NO:200) peptide 201 PLLDLFKELLEELKQKLK* (SEQ ID NO:201) peptide 202 PALELFKDLLEELRQKLR* (SEQ ID NO:202) peptide 203 AVLDLFRELLEELKQKLK* (SEQ ID NO:203) peptide 204 PVLDFFRELLEELKQKLK* (SEQ ID NO:204) peptide 205 PVLDLFREWLEELKQKLK* (SEQ ID NO:205) peptide 206 PLLELLKELLEELKQKLK* (SEQ ID NO:206) peptide 207 PVLELLKELLEELKQKLK* (SEQ ID NO:207) peptide 208 PALELFKDLLEELRQRLK* (SEQ ID NO:208) peptide 209 PVLDLFRELLNELLQKLK (SEQ ID NO:209) peptide 210 PVLDLFRELLEELKQKLK (SEQ ID NO:210) peptide 213 PALELFKDLLEEFRQRLK* (SEQ ID NO: 213) peptide 215 PVLDLFRELLEEWKQKLK* (SEQ ID NO:215) peptide 229 PVLELFERLLEDLQKKLK (SEQ ID NO:229) peptide 230 PVLDLFRELLEKLEQKLK (SEQ ID NO: 230) peptide 231 PLLELFKELLEELKQKLK* (SEQ ID NO:231) 50. A nucleotide sequence encoding a multimeric ApoA-I agonist which exhibits at leaεt about 38% LCAT activation activity aε compared with human ApoA-I and which haε the εtructural formula (IV) : (IV) HHfLI^-HH .LI^-HH or a pharmaceutically acceptable εalt thereof, wherein: each m is independently an integer from 0 to 1; n is an integer from 0 to 10; each "HH H iε independently a peptide or peptide analogue according to Claim 1 or 18 or 36; and; each "LL" iε independently a bifunctional linker. 51. A hoεt cell expreεεing a peptide encoded by the nucleotide εequence of Claim 1, 18 or 36. 52. A host cell expressing a peptide encoded by the nucleotide sequence of Claim 17, 35 or 49. 53. A host cell expresεing a peptide encoded by the nucleotide sequence of Claim 50. 54. A pharmaceutical composition comprising nucleotide sequences encoding an ApoA-I agonist and a pharmaceutically acceptable carrier, excipient or diluent, wherein the ApoA-I agonist iε encoded by the nucleotide sequences of Claim 1, 18 or 36. 55. A pharmaceutical composition comprising nucleotide sequences encoding an ApoA-I agonist and a pharmaceutically acceptable carrier, excipient or diluent, wherein the ApoA-I agonist is encoded by the nucleotide sequences of Claim 17 , 35 or 49. 56. A pharmaceutical composition comprising nucleotide sequences encoding an ApoA-I agonist and a pharmaceutically acceptable carrier, excipient or diluent, wherein the ApoA-I agonist is encoded by the nucleotide εequenceε of Claim 50. 57. A pharmaceutical compoεition of Claim 54, in which the nucleotide εequence iε in the form of a nucleotide lipid complex, εaid complex compriεing the nucleotide εequenceε encoding an ApoA-I agoniεt and a lipid. 58. A method of treating a εubject suffering from a disorder aεsociated with dyεlipidemia, εaid method compriεing the εtep of adminiεtrating to the εubject an effective amount of a nucleotide εequence or a hoεt cell expreεεing the nucleotide εequence of Claims 1, 18 or 36. 59. The method of Claim 59 in which the ApoA-I agonist iε in the form of an ApoA-I agoniεt-lipid complex, said complex comprising the ApoA-I agonist and a lipid. 60. The method of Claim 58 in which the ApoA-I agoniεt iε in the form of a pharmaceutical composition, said composition comprising the ApoA-I agonist and a pharmaceutically acceptable carrier, excipient or diluent. 61. The method of Claim 58 in which the disorder aεεociated with dyεlipidemia is hypercholesterol. 62. The method of Claim 58 in which the disorder associated with dyslipidemia is cardiovascular disease. 63. The method of Claim 58 in which the disorder associated with dyslipidemia is atherosclerosis. 64. The method of Claim 58 in which the disorder associated with dyslipidemia is restenosis. 65. The method of Claim 58 in which the disorder associated with dyslipidemia is an HDL or ApoA-I deficiency. 66. The method of Claim 58 in which the disorder associated with dyslipidemia iε hypertriglyceridemia. 67. The method of Claim 58 in which the diεorder associated with dyslipidemia is a metabolic syndrome. 68. The method of treating a subject suffering from a disorder associated with endotoxemia εeptic shock, said method comprising the step of administering to the subject an effective amount of a nucleotide εequence or a hoεt cell expressing the nucleotide sequence of Claims 1, 18 or 36.

Inventors: BUTTNER KLAUS, CORNUT ISABELLE, DASSEUX JEAN-LOUIS, DUFOURCQ JEAN, METZ GUNTHER, SEKUL RENATE, BUTTNER, KLAUS, CORNUT, ISABELLE, DASSEUX, JEAN-LOUIS, DUFOURCQ, JEAN, METZ, GUNTHER, SEKUL, RENATE
Applicants: BUTTNER KLAUS, CORNUT ISABELLE, DASSEUX JEAN LOUIS, DUFOURCQ JEAN, METZ GUNTHER, SEKUL RENATE, BUTTNER, KLAUS, CORNUT, ISABELLE, DASSEUX, JEAN-LOUIS, DUFOURCQ, JEAN, METZ, GUNTHER, SEKUL, RENATE
Application year: 1998
Main classification: A61K
IPC codes: A61K38, A61K48, A61P3, A61P9, A61P31, A61P43, C07H21, C07K7, C07K14, C12N5, C12N15