SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS

Abstract: Selected substituted pyridine compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein a. o. X is O, S, S(O), S(O)2 or NR<2>; Y is -C(O)-NR<3>R<4> or -NR<4>-C(O)-R<3>; R<1> is a cycloalkyl, aryl, heterocyclyl or heteroaryl radical which is optionally substituted by 1-4 radicals of alkyl, halo, haloalkyl, cyano, azido, nitro, amidino, R<18>-Z<18>- or R<18>-Z<18>-alkyl; provided that the total number of aryl, heteroaryl, cycloalkyl and heterocyclyl radicals in R<1> is 1-3; and provided when Y is -NR<4>-C(O)-R<3> and X is O or S, R<1> is other than a 2-pyrimidinyl radical; R<2> is a hydrogen or alkyl radical; R<3> is an aryl or heteroaryl radical which is optionally substituted by 1-5 radicals of alkyl, halo, haloalkyl, cyano, azido, nitro, amidino, R<19>-Z<19>- or R<19>-Z<19>-alkyl; provided that the total number of aryl and heteroaryl radicals in R<3> is 1-3; and provided when Y is -C(O)- NR<3>R<4>, R<3> is other than a phenyl or naphthyl having an amino, nitro, cyano, carboxy or alkoxycarbonyl, are effective for prophylaxis and treatment of diseases, such as TNF- alpha , IL-1 beta , IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Description: SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS BACKGROUND OF THE INVENTION The present invention comprises a new class of compounds useful in treating diseases, such as TNF-α, IL-lβ, IL-6 and/or IL-8 mediated diseases and other maladies, such as pain, cancer, and diabetes. In particular, the compounds of the invention are useful for the prophylaxis and treatment of diseases or conditions involving inflammation. This invention also relates to intermediates and processes useful in the preparation of such compounds . Interleukin-1 (IL-1) and Tumor Necrosis Factor α (TNF-α) are pro-inflammatory cytokines secreted by a variety of cells, including monocytes and macrophages , in response to many inflammatory stimuli (e.g., lipopolysaccharide - LPS) or external cellular stress (e.g., osmotic shock and peroxide). Elevated levels of TNF-α and/or IL-1 over basal levels have been implicated in mediating or exacerbating a number of disease states including rheumatoid arthritis; Pagets disease; osteophorosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; pancreatic β cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS) ; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; asthma; muscle degeneration; cachexia; Reiter's syndrome; type I and type II diabetes; bone resorption diseases; graft vs. host reaction; ischemia reperfusion injury; atherosclerosis; brain trauma; multiple sclerosis; cerebral malaria; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection. HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV) , influenza, adenovirus, the herpes viruses (including HSV-1, HSV-2), and herpes zoster are also exacerbated by TNF-α. It has been reported that TNF-α plays a role in head trauma, stroke, and ischemia. For instance, in animal models of head trauma (rat) , TNF-α levels increased in the contused hemisphere (Shohami et al . , J " . Cereb. Blood Flow Metab. 14, 615 (1994)). In a rat model of ischemia wherein the middle cerebral artery was occluded, the levels of TNF-α mRNA of TNF-α increased (Feurstein et al . , Neurosci . Lett . 164, 125 (1993)). Administration of TNF-α into the rat cortex has been reported to result in significant neutrophil accumulation in capillaries and adherence in small blood vessels. TNF-α promotes the infiltration of other cytokines (IL-lβ, IL-6) and also chemokines , which promote neutrophil infiltration into the infarct area (Feurstein, Stroke 25 , 1481 (1994)). TNF-α has also been implicated to play a role in type II diabetes (Endocrinol. 130, 43-52, 1994; and Endocrinol . 136, 1474-1481, 1995). TNF-α appears to play a role in promoting certain viral life cycles and disease states associated with them. For instance, TNF-α secreted by monocytes induced elevated levels of HIV expression in a chronically infected T cell clone (Clouse et al . , J. Immunol . 142, 431 (1989)). ahdevirta et al . , (Am. J. Med. 85, 289 (1988)) discussed the role of TNF-α in the HIV associated states of cachexia and muscle degradation. TNF-α is upstream in the cytokine cascade of inflammation. As a result, elevated levels of TNF-α may lead to elevated levels of other inflammatory and proinflammatory cytokines, such as IL-1, IL-6, and IL-8. Elevated levels of IL-1 over basal levels have been implicated in mediating or exacerbating a number of disease states including rheumatoid arthritis; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS) ; psoriasis; Crohn's disease; ulcerative colitis; anaphylaxis; muscle degeneration; cachexia; Reiter's syndrome; type I and type II diabetes; bone resorption diseases; ischemia reperfusion injury; atherosclerosis; brain trauma; multiple sclerosis; sepsis; septic shock; and toxic shock syndrome. Viruses sensitive to TNF-α inhibition, e . g. , HIV-1, HIV-2, HIV- 3, are also affected by IL-1. TNF-α and IL-1- appear to play a role in pancreatic β cell destruction and diabetes. Pancreatic β cells produce insulin which helps mediate blood glucose homeostasis. Deterioration of pancreatic β cells often accompanies type I diabetes. Pancreatic β cell functional abnormalities may occur in patients with type II diabetes. Type II diabetes is characterized by a functional resistance to insulin. Further, type II diabetes is also often accompanied by elevated levels of plasma glucagon and increased rates of hepatic glucose production. Glucagon is a regulatory hormone that attenuates liver gluconeogenesis inhibition by insulin. Glucagon receptors have been found in the liver, kidney and adipose tissue. Thus glucagon antagonists are useful for attenuating plasma glucose levels (WO 97/16442, incorporated herein by reference in its entirety). By antagonizing the glucagon receptors, it is thought that insulin responsiveness in the liver will improve, thereby decreasing gluconeogenesis and lowering the rate of hepatic glucose production. In rheumatoid arthritis models in animals, multiple intra-articular injections of IL-1 have led to an acute and destructive form of arthritis (Chandrasekhar et al . , Clinical Immunol Immunopathol . 55, 382 (1990)). In studies using cultured rheumatoid synovial cells, IL-1 is a more potent inducer of stromelysin than is TNF-α (Firestein, Am . J. Pathol . 140, 1309 (1992)). At sites of local injection, neutrophil, lymphocyte, and monocyte emigration has been observed. The emigration is attributed to the induction of chemokines (e.g., IL-8), and the up-regulation of adhesion molecules (Dinarello, Eur. Cytokine Netw. 5, 517-531 (1994)). IL-1 also appears to play a role in promoting certain viral life cycles. For example, cytokine- induced increase of HIV expression in a chronically infected macrophage line has been associated with a concomitant and selective increase in IL-1 production (Folks et al., J " . Immunol . 136, 40 (1986)). Beutler et al. (J. Immunol . 135, 3969 (1985)) discussed the role of IL-1 in cachexia. Baracos et al . (New Eng. J. Med. 308, 553 (1983)) discussed the role of IL-1 in muscle degeneration. In rheumatoid arthritis, both IL-1 and TΝF-α induce synoviocytes and chondrocytes to produce collagenase and neutral proteases, which leads to tissue destruction within the arthritic joints. In a model of arthritis (collagen-induced arthritis (CIA) in rats and mice) , intra-articular administration of TΝF-α either prior to or after the induction of CIA led to an accelerated onset of arthritis and a more severe course of the disease (Brahn et al . , Lymphokine Cytokine Res . 11, 253 (1992); and Cooper, Clin . Exp . Immunol . 898, 244 (1992) ) . IL-8 has been implicated in exacerbating and/or causing many disease states in which massive neutrophil infiltration into sites of inflammation or injury (e.g., ischemia) is mediated by the chemotactic nature of IL-8, including, but not limited to, the following: asthma, inflammatory bowel disease, psoriasis, adult respiratory distress syndrome, cardiac and renal reperfusion injury, thrombosis and glomerulonephritis . In addition to the chemotaxis effect on neutrophils, IL-8 also has the ability to activate neutrophils. Thus, reduction in IL- 8 levels may lead to diminished neutrophil infiltration. Several approaches have been taken to block the effect of TNF-α. One approach involves using soluble receptors for TNF-α (e.g., TNFR-55 or TNFR-75) , which have demonstrated efficacy in animal models of TNF-α- mediated disease states. A second approach to neutralizing TNF-α using a monoclonal antibody specific to TNF-α, cA2 , has demonstrated improvement in swollen joint count in a Phase II human trial of rheumatoid arthritis (Feldmann et al . , Immunological Reviews , pp. 195-223 (1995)). These approaches block the effects of TNF-α and IL-1 by either protein sequestration or receptor antagonism. The present invention also relates to a method of treating cancer which is mediated by Raf and Raf- inducable proteins . Raf proteins are kinases activated in response to extracellular mitogenic stimuli such as PDGF, EGF, acidic FGF, thrombin, insulin or endothelin, and also in response to oncoproteins such as v-src, v- sis, and v-fms. Raf functions downstream of ras in signal transduction from the cellular membrane to the nucleus. Compounds in the present invention may be oncolytics through the antagonism of Raf kinase. Antisense constructs which reduce cellular levels of c- Raf and hence Raf activity inhibit the growth of rodent fibroblasts in soft agar, while exhibiting little or no general cytotoxicity. This inhibition of growth in soft agar is highly predictive of tumor responsiveness in whole animals. Moreover Raf antisense constructs have shown efficacy in reducing tumor burden in animals. Examples of cancers where Raf kinase is implicated by overexpression include cancers of the brain, larynx, lung, lymphatic system, urinary tract and stomach, including hystocytic lymphoma, lung adenocarcinoma and small cell lung cancers. Other examples include cancers involving overexpression of upstream activators of Raf or Raf-activating oncogenes , including pancreatic and breast carcinoma. Substituted imidazole and pyrrole compounds have been described for use in the treatment of cytokine mediated diseases by inhibition of proinflammatory cytokines, such as I -1, IL-6, IL-8 and TNF. Substituted imidazoles for use in the treatment of cytokine mediated diseases have been described in US Pat. 5,593,992; WO 93/14081; WO 97/18626; WO 96/21452; WO 96/21654; WO 96/40143; WO 97/05878; WO 97/05878; (each of which is incorporated herein by reference in its entirety) . Substituted imidazoles for use in the treatment of inflammation has been described in US Pat. 3,929,807 (which is incorporated herein by reference in its entirety) . Substituted pyrrole compounds for use in the treatment of cytokine mediated diseases have been described in WO 97/05877; WO 97/05878; WO 97/16426; WO 97/16441; and WO 97/16442 (each of which is incorporated herein by reference in its entirety) . Substituted 2-aminopyridine compounds have been described as nitric oxide synthase inhibitors for use in the treatment of inflammation, neurodegenerative disorders and disorders of gastrointestinal motility in WO 96/18616 and WO 96/18617. Diaryl substituted pyridine compounds have been described for use in the treatment of inflammation and inflammation related disorders in WO 96/24584 and US 5,596,008. US 3,980,652, US 3,991,057 and US 4,002,629 describe piperazinyl substituted pyridine compounds for use as anti-inflammatory and cardiovascular agents. JP 6135934 describes substituted pyridine compounds as phospholipase A2 inhibitors for use as antiphlogistic and anti-pancreatitis agents. GB 1,189,188 describes pyrimidin-2-ylamino substituted pyridine compounds as therapeutically valuable compounds for use as antiphlogistic agents. BRIEF DESCRIPTION OF THE INVENTION The present invention comprises a new class of compounds useful in the prophylaxis and treatment of diseases, such as TNF-α, IL-lβ, IL-6 and/or I -8 mediated diseases and other maladies, such as pain, cancer, and diabetes. In particular, the compounds of the invention are useful for the prophylaxis and treatment of diseases or conditions involving inflammation. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds, methods for the prophylaxis and treatment of TNF-α, IL- lβ, IL-6 and/or IL-8 mediated diseases, such as inflammatory, pain and diabetes diseases, using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of the compounds of the invention. The compounds of the invention are represented by the following general structure: (I) wherein R 1 , R 5 , R δ , R 7 , X and Y are defined below. The foregoing merely summarizes certain aspects of the invention and is not intended, nor should it be construed, as limiting the invention in any way. All patents and other publications recited herein are hereby incorporated by reference in their entirety. DETAILED DESCRIPTION OF THE INVENTION In accordance with the present invention, there is provided compounds of the formula: (I) or a pharmaceutically acceptable salt thereof, wherein X is 0, S, S(0), S(0) 2 or NR ; preferably, X is 0, S or 2 2 NR ; more preferably, X is 0 or NR ; most preferably, X is NR ; 3 4 Y is -C(0) -NR R or -NR -C(0)-R 1 R is a cycloalkyl, aryl, heterocyclyl or heteroaryl radical which is optionally substituted by 1-4 radicals of alkyl, halo, haloalkyl, cyano, azido, nitro, amidino, 18 18 18 18 R -Z - or R -Z -alkyl; preferably, R is a cycloalkyl, aryl, heterocyclyl or heteroaryl radical which is optionally substituted by 1- 4 radicals of Cι-C 6 alkyl, halo, Ci-Cβ haloalkyl of 1-3 18 18 halo radicals, cyano, azido, nitro, amidino, R -Z - or R 18 -Z 18 -Ci-C δ a-l,,ky-l,; ι more preferably, R is a cycloalkyl, aryl, heterocyclyl or heteroaryl radical which is optionally substituted by 1-4 radicals of C 1 -C 4 alkyl, halo, C 1 -C 4 haloalkyl of 1-3 halo radicals, cyano, azido, nitro, amidino, R -z - or 18 18 R -Z -C 1 -C 4 alkyl; provided that the total number of aryl, heteroaryl, 1 cycloalkyl and heterocyclyl radicals m R is 1-3, 4 3 preferably, 1-2, and provided when Y is -NR -C(0)-R and X is 0 or S, R is other than a 2-pyrimidinyl radical; more preferably, R is a radical of the formula 22 23 24 25 26 wherein R , R , R , R and R are each independently a radical of hydrogen, C 1 -C 4 alkyl, halo, trifluoromethyl, 18 18 18 18 cyano, azido, nitro, amidino, R -Z - or R -Z -C 1 -C 4 21 22 23 24 25 alkyl; provided at least one of R , R , R , R and R is hydrogen; and provided that the combined total number 22 23 4 25 of aryl and heteroaryl radicals in R , R , R , R and 2 2 R is a hydrogen or alkyl radical; preferably, R is a 2 . hydrogen or C 1 -C 4 alkyl radical; more preferably, R is a 2 , hydrogen or C 1 -C 2 alkyl radical; more preferably, R is a 2 , hydrogen or methyl radical; and most preferably, R is a hydrogen radical ; R is an aryl or heteroaryl radical which is optionally substituted by 1-5 radicals of alkyl, halo, haloalkyl, . .. 19 19 19 19 „ , , cyano, azido, nitro, amidino, R -Z - or R -Z -alkyl; preferably, R is an aryl or heteroaryl radical which is optionally substituted by 1-5 radicals of Ci-C δ alkyl, halo, C 1 -C 6 haloalkyl of 1-3 halo radicals, cyano, . -, . 19 19 19 19 , , , azido, nitro, amidino, R -Z - or R -Z -Ci-C δ alkyl; 3 more preferably, R is an aryl or heteroaryl radical which is optionally substituted by 1-5 radicals of Cχ-C6 alkyl, halo, C 1 -C 4 haloalkyl of 1-3 halo radicals, 19 19 19 19 cyano, azido, nitro, amidino, R -Z - or R -Z -C 1 -C 4 alkyl; provided that the total number of aryl and heteroaryl radicals in R is 1-3, preferably, 1-2; and provided 3 4 3 , when Y is -C(0)-NRR , R is other than a phenyl or naphthyl having an amino, nitro, cyano, carboxy or alkoxycarbonyl substituent bonded to the ring carbon 4 atom adjacent to the ring carbon atom bonded to -NR - ; more preferably, R is a radical of the formula wherein 12 V and W are each independently C-R or N; 11 13 R and R are each independently a radical of hydrogen, C1-C4 alkyl, halo, trifluoromethyl, cyano, azido, nitro, . ., . 19 19 , . 11 13 amidino or R -Z -; preferably, R and R are each independently a radical of hydrogen, methyl, ethyl, fluoro, chloro, trifluoromethyl , cyano, azido, nitro, . .. 19 19 19 19 19 amidino, R -0-, R -S(0) 2 -, R -O-C(O)-, R -C(O)-, R - 21 19 21 NR -C(O)- or R -NR -S(O)--; 12 , each R is independently a radical of hydrogen, Ci-Cβ 31 alkyl, halo, C 1 -C 4 haloalkyl of 1-3 halo radicals, R - 31 31 31 12 Z - or R -Z -C 1 -C 4 alkyl; preferably, each R is independently a radical of hydrogen, methyl, ethyl, fluoro, chloro, trifluoromethyl, trifluoromethoxy, methoxy, ethoxy, amino, methylamino, dimethylamino, acetylamino, aminocarbonyl , methylaminocarbonyl , dimethylaminocarbonyl , aminomethyl, (methylamino)methyl or (dimethy1amino) methyl; provided that the combined total number of aryl and 11 12 13 heteroaryl radicals in R , R and R is 0-1; wherein each R is independently a hydrogen, C 1 -C 4 alkyl, trifluoromethyl, aryl, heteroaryl, aryl-Cι-C 4 alkyl or heteroaryl-Cι-C 4 alkyl radical, wherein the aryl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, methoxy, ethoxy, amino, methylamino, dimethylamino, acetylamino, cyano, halo, methyl, ethyl, trifluoromethyl or trifluoromethoxy; each Z is independently -0-, -NR -, -NR -C(O)-, -C(O)- NR 21 -, -NR 21 -S(0),- or -S (0) ,-NR 21 - ; 4 R is a hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl, heteroaryl, arylalkyl, 20 20 heteroarylalkyl or R -Z -alkyl radical, wherein the aryl and heteroaryl radicals are optionally substituted by 1-3 radicals of hydroxy, alkoxy, alkylthiol, amino, alkylamino, dialkylamino, alkanoylamino, alkylsulfonylamino, alkylsulfinyl, alkylsulfonyl, alkoxycarbonylamino, alkoxycarbonyl , cyano, halo, azido, alkyl, haloalkyl or haloalkoxy; 4 preferably, R is a radical of hydrogen, Ci-C δ alkyl, C 2 - Cβ alkenyl, Ci-C δ haloalkyl of 1-3 halo radicals, C 2 -C 6 haloalkenyl of 1-3 halo radicals, aryl, heteroaryl, 20 20 aryl-Cι-C 4 alkyl, heteroaryl-Cι-C alkyl or R -Z -C 1 -C6 alkyl radical, wherein the aryl and heteroaryl radicals are optionally substituted by 1-3 radicals of hydroxy, C 1 -C 4 alkoxy, C 1 -C 4 alkylthiol, amino, C 1 -C 4 alkylamino, di(Cχ-C 4 alkyl) amino, C 1 -C 5 alkanoylamino, C 1 -C4 alkylsulfonylamino, C 1 -C 4 alkylsulfinyl, C 1 -C 4 alkylsulfonyl, (C 1 -C 4 alkoxy) carbonylamino, (C 1 -C 4 alkoxy) carbonyl, cyano, halo, azido, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl of 1-3 halo radicals or C 1 -C 4 haloalkoxy of 1- 3 halo radicals; 4 more preferably, R is a radical of hydrogen, - s alkyl, aryl, heteroaryl, aryl-Cι-C 4 alkyl, heteroaryl- 20 20 C 1 -C 4 alkyl or R -Z -C 2 -C 4 alkyl radical, wherein the aryl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, C 1 -C 4 alkoxy, C 1 -C4 alkylthiol, amino, C 1 -C 4 alkylamino, di(C]_-C4 alkyl) amino, acetylamino, halo, C 1 -C 4 alkyl, trifluoromethyl or trifluoromethoxy; 4 more preferably, R is a radical of hydrogen, Cχ-C 6 alkyl, aryl, heteroaryl, ryl-Cι-C 4 alkyl, heteroaryl- 20 20 C 1 -C 4 alkyl or R -Z -C 2 -C 4 alkyl radical, wherein the aryl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, methoxy, ethoxy, methylthiol, ethylthiol, amino, methylamino, dimethylamino, ethylamino, diethylamino, acetylamino, halo, methyl, ethyl, trifluoromethyl or trifluoromethoxy; 4 more preferably, R is a radical of hydrogen, methyl or ethyl radical; 18 wherein each R is' independently a hydrogen, alkyl, haloalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl radical, wherein the aryl and heteroaryl radicals are optionally substituted by 1-3 radicals of hydroxy, alkoxy, alkylthiol, amino, alkylamino, dialkylamino, alkanoylamino, alkylsulfonylamino, alkylsulfinyl, alkylsulfonyl, alkoxycarbonylami.no, alkoxycarbonyl , cyano, halo, azido, alkyl, haloalkyl or haloalkoxy; 18 preferably, each R is independently a hydrogen, C 1 -C4 alkyl, C 1 -C 4 haloalkyl of 1-3 halo radicals, aryl, heteroaryl, aryl-Cι-C 4 alkyl or heteroaryl-Cι-C 4 alkyl radical, wherein the aryl and heteroaryl radicals are optionally substituted by 1-3 radicals of hydroxy, C1-C4 alkoxy, C 1 -C 4 alkylthiol, amino, C 1 -C 4 alkylamino, di(Cι~ C 4 alkyl) amino, C 1 -C 5 alkanoylamino, C 1 -C4 alkylsulfonylamino, C 1 -C 4 alkylsulfinyl, C 1 -C4 alkylsulfonyl, (C 1 -C 4 alkoxy) carbonylamino, (C1-C4 alkoxy) carbonyl, cyano, halo, azido, C 1 -C 4 alkyl, C 1 -C4 haloalkyl of 1-3 halo radicals or C 1 -C 4 haloalkoxy of 1- 3 halo radicals; 18 more preferably, each R is independently a hydrogen, C 1 -C 4 alkyl, trifluoromethyl , aryl, heteroaryl, aryl-Ci- C 2 alkyl or heteroaryl-Cι-C 2 alkyl radical, wherein the aryl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, C 1 -C 4 alkoxy, C 1 -C 4 alkylthiol, amino, C 1 -C 4 alkylamino, di (C 1 -C 4 alkyl) amino, acetylamino, cyano, halo, azido, C 1 -C 4 alkyl, trifluoromethyl or trifluoromethoxy; 18 each Z is independently -0-, -S-, -S(O)-, -S(O) 2 C0 2 -, -C(O)-, -NR 21 -, -NR 21 -C(0)-, -C(0)-NR 21 -, -NR 21 - 21 18 S(0) 2 - or -S(0) 2 -NR - ; preferably, each Z is 21 21 independently -0-, -S-, -S(0) 2 -, -C0 2 -, -NR -, -NR - C(O)-, -C(0)-NR 21 -, -NR 21 -S(0) 2 - or -S (0) 2 -NR 21 - ; 19 wherein each R is independently a hydrogen, alkyl, haloalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl radical, wherein the aryl and heteroaryl radicals are optionally substituted by 1-3 radicals of hydroxy, alkoxy, alkylthiol, amino, alkylamino, dialkylamino, alkanoylamino, alkylsulfonylamino, alkylsulfinyl, alkylsulfonyl, alkoxycarbonylamino, alkoxycarbonyl , cyano, halo, azido, alkyl, haloalkyl or haloalkoxy; 19 preferably, each R is independently a hydrogen, C1-C4 alkyl, C 1 -C 4 haloalkyl of 1-3 halo radicals, aryl, heteroaryl, aryl-Cι~C 4 alkyl or heteroaryl-Cι-C 4 alkyl radical, wherein the aryl and heteroaryl radicals are optionally substituted by 1-3 radicals of hydroxy, C1-C4 alkoxy, C 1 -C 4 alkylthiol, amino, C 1 -C 4 alkylamino, di(Cι- C 4 alkyl) amino, C 1 -C 5 alkanoylamino, C 1 -C4 alkylsulfonylamino, C 1 -C 4 alkylsulfinyl, C 1 -C4 alkylsulfonyl, (C 1 -C 4 alkoxy) carbonylamino, (C 1 -C 4 alkoxy) carbonyl, cyano, halo, azido, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl of 1-3 halo radicals or C 1 -C 4 haloalkoxy of 1- 3 halo radicals; 19 more preferably, each R is independently a hydrogen, C 1 -C 4 alkyl, trifluoromethyl , aryl, heteroaryl, aryl-Ci- C 4 alkyl or heteroaryl-Cι-C 4 alkyl radical, wherein the aryl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, C 1 -C 4 alkoxy, C 1 -C 4 alkylthiol, amino, C 3. -C 4 alkylamino, di(Cι-C 4 alkyl) amino, acetylamino, cyano, halo, C 1 -C 4 alkyl, trifluoromethyl or trifluoromethoxy; 19 more preferably, each R is independently a hydrogen, C 1 -C 4 alkyl, trifluoromethyl , aryl, heteroaryl, aryl-Ci- C 4 alkyl or heteroaryl-Cι-C 4 alkyl radical; wherein the aryl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, methoxy, ethoxy, amino, methylamino, dimethylamino, acetylamino, cyano, halo, methyl, ethyl, trifluoromethyl or trifluoromethoxy; 19 more preferably, each R is independently a hydrogen, methyl, ethyl, trifluoromethyl, phenyl, heteroaryl, phenylmethyl or heteroaryl-methyl radical, wherein the phenyl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, methoxy, ethoxy, amino, methylamino, dimethylamino, acetylamino, cyano, fluoro, chloro, methyl, ethyl, trifluoromethyl or trifluoromethoxy; 19 each Z is independently -0-, -S-, -S(O)-, -S(0) 2 -, - C0 2 -, -C(O)-, -NR 21 -, -NR 21 -C(0)-, -C(0)-NR -, -NR - 21 19 . S(0)„- or -S(0) 2 -NR -,- preferably, each Z is independently -0-, -S(0) 2 - , -C0 2 -, -C(O)-, -NR 21 -C(0)-, - 21 C(0)-NR 21 -, -NR 21 -S(0) 2 - or -S(0) 2 -NR -; more preferably, 19 . each Z is independently - -0-, -S(0) 2 -, -O-C(O)-, -C(O)- -NR 21 -C(0)- or -NR 21 -S(0) ? -; 20 wherein each R is independently a hydrogen, alkyl, haloalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl radical, wherein the aryl and heteroaryl radicals are optionally substituted by 1-3 radicals of hydroxy, alkoxy, alkylthiol, amino, alkylamino, dialkylamino, alkanoylamino, alkylsulfonylamino, alkylsulfinyl, alkylsulfonyl, alkoxycarbonylamino, alkoxycarbonyl , cyano, halo, azido, alkyl, haloalkyl or haloalkoxy; 20 preferably, each R s independently a hydrogen, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl of 1-3 halo radicals, aryl, heteroaryl, aryl-Cι-C 4 alkyl or heteroaryl-Cι-C 4 alkyl radical, wherein the aryl and heteroaryl radicals are optionally substituted by 1-3 radicals of hydroxy, C 1 -C 4 alkoxy, C 1 -C 4 alkylthiol, amino, C 1 -C 4 alkylamino, di(C]_- C 4 alkyl) amino, C 1 -C 5 alkanoylamino, C 1 -C 4 alkylsulfonylamino, C 1 -C 4 alkylsulfinyl, C 1 -C 4 alkylsulfonyl, (C 1 -C 4 alkoxy) carbonylamino, (C 1 -C 4 alkoxy) carbonyl, cyano, halo, azido, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl of 1-3 halo radicals or C 1 -C 4 haloalkoxy of 1- 3 halo radicals; 20 more preferably, each R is independently a hydrogen, C 1 -C 4 alkyl, aryl, heteroaryl, aryl-Cι-C 2 alkyl or heteroaryl-Cι-C 2 alkyl radical, wherein the aryl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, C 1 -C 4 alkoxy, C 1 -C 4 alkylthiol, amino, C 1 -C 4 alkylamino, di (C 1 -C 4 alkyl)amino, acetylamino, halo, C 1 -C 4 alkyl, trifluoromethyl or trifluoromethoxy; 20 more preferably, each R is independently a hydrogen, C 1 -C 4 alkyl, aryl, heteroaryl, aryl-Cι~C 2 alkyl or heteroaryl-Cι-C 2 alkyl radical, wherein the aryl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, methoxy, ethoxy, methylthiol, ethylthiol, amino, methylamino, dimethylamino, ethylamino, diethylamino, acetylamino, halo, methyl, ethyl, trifluoromethyl or trifluoromethoxy; 20 each Z is independently -0-, -S-, -S(O)-, -S(0) 2 -, - C0 2 -, -C(O)-, -NR 21 -, -NR 21 -C(0)-, -C(0)-NR 21 -, -NR 21 - S(0) 2 - or -S(0) 2 -NR - ; preferably, each Z is 21 independently -0- or -NR -; 21 wherein each R is independently a hydrogen or alkyl 21 radical; preferably, each R is independently a hydrogen 21 . or C 1 -C 4 alkyl radical; more preferably, each R is independently a hydrogen or methyl radical; 5 6 R and R are each independently a hydrogen, alkyl, halo, haloalkyl, haloalkoxy, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl , amino, alkylamino, dialkylamino, alkanoylamino, alkylsulfonylamino, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, hydroxy, hydroxyalkyl , thiol, alkylthiol, alkylsulfinyl, alkylsulfonyl, alkoxy, alkoxyalkyl, cyano, azido, nitro, carboxy, alkoxycarbonyl , aminocarbonyl , alkylaminocarbonyl or dialkylaminocarbonyl radical; preferably, R and R are each independently a hydrogen, C 1 -C 4 alkyl, halo, C 1 -C 4 haloalkyl of 1-3 halo radicals, C1-C4 haloalkoxy of 1-3 halo radicals, C 1 -C 4 aminoalkyl, (C 1 -C 4 alkyl) amino-Cι-C 4 alkyl, di(Cχ-C 4 alkyl) amino-Ci- C 4 alkyl, amino, C 1 -C 4 alkylamino, di (C 1 -C 4 alkyl)amino, C 1 -C5 alkanoylamino, C 1 -C 4 alkylsulfonylamino, aminosulfonyl, C 1 -C 4 alkylaminosulfonyl, di (C 1 -C 4 alkyl) aminosulfonyl, hydroxy, C 1 -C 4 hydroxyalkyl , thiol, C 1 -C 4 alkylthiol, C 1 -C 4 alkylsulfinyl , C 1 -C 4 alkylsulfonyl, C 1 -C 4 alkoxy, (C 1 -C 4 alkoxy) C 1 -C 4 alkyl, cyano, azido, nitro, carboxy, (C 1 -C 4 alkoxy) carbonyl, aminocarbonyl , (C 1 -C 4 alkyl) aminocarbonyl or di(Cι-C 4 alkyl ) aminocarbonyl radical ; 5 6 more preferably, R and R are each independently a hydrogen, C 1 -C 4 alkyl, halo, trifluoromethyl, trifluoromethoxy, amino, C 1 -C 4 alkylamino, i(Cι-C 4 alkyl) amino, C 1 -C 5 alkanoylamino, hydroxy, C 1 -C 4 hydroxyalkyl, C 1 -C 4 alkoxy, cyano, azido, nitro, carboxy, (C 1 -C 4 alkoxy) carbonyl, aminocarbonyl, (C 1 -C 4 alkyl ) aminocarbonyl or i(Cι-C 4 alkyl) aminocarbonyl radical; 5 6 more preferably, R and R are each independently a hydrogen, methyl, ethyl, halo, trifluoromethyl, trifluoromethoxy, amino, C 1 -C 2 alkylamino, di(Cχ-C2 alkyl) amino, hydroxy, methoxy or ethoxy radical; most preferably, R and R are each a hydrogen radical; 7 R is a hydrogen, alkyl, halo, haloalkyl, haloalkoxy, aminoalkyl , alkylaminoalkyl , dialkylaminoalkyl , aminosulfonyl, alkylaminosulfonyl, dialkylammosulfonyl, hydroxy, hydroxyalkyl, thiol, alkylthiol, alkylsulfinyl, alkylsulfonyl, alkoxy, alkoxyalkyl, cyano, azido, nitro, carboxy, alkoxycarbonyl , aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl radical; 7 preferably, R is a hydrogen, C 1 -C 4 alkyl, halo, C 1 -C 4 haloalkyl of 1-3 halo radicals, C 1 -C 4 haloalkoxy of 1-3 halo radicals, C 1 -C 4 aminoalkyl, (C 1 -C 4 alkyl) amino-Cι-C 4 alkyl, di (C 1 -C 4 alkyl) amino-Cι-C 4 alkyl, aminosulfonyl, C 1 -C 4 alkylaminosulfonyl, di(Cχ-C 4 alkyl) aminosulfonyl , hydroxy, C 1 -C 4 hydroxyalkyl, thiol, C 1 -C 4 alkylthiol, Cχ~ C 4 alkylsulfinyl, C 1 -C 4 alkylsulfonyl, C 1 -C 4 alkoxy, (Cχ~ C 4 alkoxy) C 1 -C 4 alkyl, cyano, azido, nitro, carboxy, (Cχ~ C 4 alkoxy) carbonyl, aminocarbonyl, (C 1 -C 4 alkyl) aminocarbonyl or di(Cχ-C 4 alkyl) aminocarbonyl radical; 7 more preferably, R is a hydrogen, C 1 -C 4 alkyl, halo, trifluoromethyl, trifluoromethoxy, hydroxy, C 1 -C 4 hydroxyalkyl, C 1 -C 4 alkoxy, carboxy, (C 1 -C 4 alkoxy) carbonyl, aminocarbonyl, (C 1 -C 4 alkyl) aminocarbonyl or di(Cι~C 4 alkyl) aminocarbonyl radical; 7 more preferably, R is a hydrogen, methyl, ethyl, halo, trifluoromethyl, trifluoromethoxy, hydroxy, methoxy or 7 ethoxy radical; most preferably, R is a hydrogen radical. The compounds of this invention may have in general several asymmetric centers and are typically depicted in the form of racemic mixtures . This invention is intended to encompass racemic mixtures, partially racemic mixtures and separate enantiomers and diasteromers . Compounds of interest include the following: 2-cyclohexyloxy-5- (2-chlorophenylcarbonylamino)pyridine; 2-cyclohexyloxy-5- (2-methylphenylcarbonylamino) pyridine; 2-cyclohexyloxy-5- (2, 6-dichlorophenylcarbonylamino) pyridine; 2-cyclohexyloxy-5- (2, 6-dimethylphenylcarbonylamino) pyridine; 2- (2, 4-dimethylphenoxy) -5- (2-chlorophenylcarbonylamino) pyridine; 2- (2, 4-dimethylphenoxy) -5- (2, 6-dichlorophenylcarbonyl amino) pyridine; 2- (2, 4-dimethylphenoxy) -5- (2-methyIphenylcarbonylamino) pyridine; 2- (2, 6-dimethyl-4-chlorophenoxy) -5- (2, 6-dimethyIphenyl carbonylamino) pyridine; 2- (2-methyl-4-fluorophenoxy) -5- (2-methyIphenylcarbonyl amino) pyridine; 2- (2-methyl-4-chlorophenoxy) -5- (2-chlorophenylcarbonyl amino) pyridine; 2- (2-methyl-4-chlorophenoxy) -5- (2-methyIphenylcarbonyl amino)pyridine; 2- (2-methylphenoxy) -5- (2-chlorophenylcarbonylamino) pyridine; 2- (2-methylphenoxy) -5- (2, 6-dichlorophenyl carbonylamino) pyridine; 2- (2-methylphenoxy) -5- (2-methylphenylcarbonyl amino) pyridine; 2- (2-methyl-4-chlorophenoxy) -5- (2, 6-dichlorophenyl carbonylamino)pyridine; 2- (2-methyl-4-chlorophenoxy) -5- (2, 6-dimethyIphenyl carbonylamino) pyridine; 2- (4-chlorophenoxy) -5- (2 , 6-dimethyIphenylcarbonylamino) pyridine; 2- (2-methyl-4-fluorophenoxy) -5- (2, 6-dichlorophenyl carbonylamino)pyridine; 2- (2-methyl-4-fluorophenoxy) -5- (2, 6-dimethylphenyl carbonylamino)pyridine; 2- (2-methylphenoxy) -5- (2, 6-dimethyIphenyl carbonylamino)pyridine; 2- (2-methyl-4-fluorophenoxy) -5- (2-fluorophenylcarbonyl amino) pyridine; 2- (2 , 4-dimethylphenoxy) -5- (2 , 6-dimethylphenylcarbonyl amino) pyridine; 2- (1-naphthyloxy) -5- (2-methylphenylcarbonylamino) pyridine; 2- (1-naphthyloxy) -5- (2, 6-dichlorophenylcarbonylamino) pyridine; 2- (1-naphthyloxy) -5- (2 , 6-dimethylphenylcarbonylamino) pyridine; 2- (2-methyl-3-pyridyloxy) -5- (2, 6-dichlorophenylcarbonyl amino)pyridine; 2- (2-methyl-4-chlorophenoxy) -5- ( (3 , 5-dimethyl-4- isoxazolyl) carbonylamino)pyridine; 2- (2-methyl-4-chlorophenylthiol) -5- (2- methyIphenylcarbonyl amino)pyridine; 2- (2-methyl-4-chlorophenylthiol) -5- (2 , 6- dimethylphenylcarbonyl amino) pyridine; 2-cyclohexylamino-5- (2 , 6-dichlorophenylcarbonylamino) pyridine; 2-cyclohexylamino-5- (2 , 6-dimethylphenylcarbonylamino) pyridine; 2- (2-methylcyclohexylamino) -5- (2,6- dichlorophenylcarbonyl amino) pyridine; 2- (2-methylcyclohexylamino) -5- (2-methylphenylcarbonyl amino)pyridine; 2- (2, 4-dimethylphenylamino) -5- (2-fluorophenylcarbonyl amino) yridine; 2- (2, 4-dimethylphenylamino) -5- (2-chlorophenylcarbonyl amino)pyridine; 2- (2 , 4-dimethylphenylamino) -5- (2,6- dichlorophenylcarbonyl amino)pyridine; 2- (2-methyl-4-chlorophenylamino) -5- (2, 6- dichlorophenylcarbonylamino)pyridine; 2- (2 , 4-dimethylphenylamino) -5- (2-methyIphenylcarbonyl amino)pyridine; 2- (2-methylphenylamino) -5- (2-methylphenylcarbonyl amino) pyridine; 2- (2-methylphenylamino) -5- (2, 6-dichlorophenylcarbonyl amino) pyridine; 2- (2-methyIphenylamino) -5- (2 , 6-dimethylphenylcarbonyl amino) pyridine; 2- (2 , 4-dimethylphenylamino) -5- (2 , 6- dimethyIphenylcarbonyl amino) pyridine; 2- (2-methyl-4-chlorophenylamino) -5- (2-methylphenyl carbonylamino) pyridine; 2- (2-methyl-4-chlorophenylamino) -5- (2, 6-dimethylphenyl carbonylamino) pyridine; and 2- (2-methyl-4-chlorophenylamino) -5- (2-methyIphenyl aminocarbonyl ) pyridine . As utilized herein, the following terms shall have the following meanings: "Alkyl", alone or in combination, means a straight-chain or branched-chain alkyl radical containing preferably 1- 15 carbon atoms (Cχ-Cχ 5 ) , more preferably 1-8 carbon atoms (Cχ-C δ ) , even more preferably 1-6 carbon atoms (Cχ-C δ ) , yet more preferably 1-4 carbon atoms (Cχ-C 4 ) , still more preferably 1-3 carbon atoms (Cχ-C 3 ) , and most preferably 1-2 carbon atoms (Cχ-C 2 ) . Examples of such radicals include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, iso- amyl, hexyl, octyl and the like. "Hydroxyalkyl", alone or in combination, means an alkyl radical as defined above wherein at least one hydrogen radical is replaced with a hydroxyl radical, preferably 1-3 hydrogen radicals are replaced by hydroxyl radicals, more preferably 1-2 hydrogen radicals are replaced by hydroxyl radicals, and most preferably one hydrogen radical is replaced by a hydroxyl radical . Examples of such radicals include hydroxymethyl , 1-, 2-hydroxyethyl, 1-, 2-, 3-hydroxypropyl , 1, 3-dihydroxy-2-propyl, 1,3- dihydroxybutyl , 1, 2 , 3 , 4 , 5 , 6-hexahydroxy-2-hexyl and the like. "Alkenyl", alone or in combination, means a straight- chain or branched-chain hydrocarbon radical having one or more double bonds, preferably 1-2 double bonds and more preferably one double bond, and containing preferably 2-15 carbon atoms (C 2 -C X5 ) , more preferably 2-8 carbon atoms (C 2 -C 8 ) , even more preferably 2-6 carbon atoms (C 2 -C 6 ) , yet more preferably 2-4 carbon atoms (C 2 -C 4 ) , and still more preferably 2-3 carbon atoms (C 2 -C ) . Examples of such alkenyl radicals include ethenyl, propenyl, 2-methylpropenyl, 1,4- butadienyl and the like. "Alkoxy" , alone or in combination, means a radical of the type "R-0-" wherein "R" is an alkyl radical as defined above and "0" is an oxygen atom. Examples of such alkoxy radicals include methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, iso-butoxy, sec-butoxy, tert- butoxy and the like. "Alkoxycarbonyl" , alone or in combination, means a radical of the type "R-O-C(O)-" wherein "R-0-" is an alkoxy radical as defined above and "C(O)" is a carbonyl radical . "Alkoxycarbonylamino" , alone or in combination, means a radical of the type "R-O-C (0) -NH-" wherein "R-O-C(O)" is an alkoxycarbonyl radical as defined above, wherein the amino radical may optionally be substituted, such as with alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl and the like. "Alkylthio", alone or in combination, means a radical of the type "R-S-" wherein "R" is an alkyl radical as defined above and "S" is a sulfur atom. Examples of such alkylthio radicals include methylthio, ethylthio, n-propylthio, isopropylthio, n-butylthio, iso-butylthio, sec-butylthio, tert-butylthio and the like. "Alkylsulfinyl" , alone or in combination, means a radical of the type "R-S(O)-" wherein "R" is an alkyl radical as defined above and "S(O)" is a mono-oxygenated sulfur atom. Examples of such alkylsulfinyl radicals include methylsulfinyl, ethylsulfinyl, n-propylsulfinyl, isopropylsulfinyl, n-butylsulfinyl, iso-butylsulfinyl, sec-butylsulfinyl, tert-butylsulfinyl and the like. "Alkylsulfonyl", alone or in combination, means a radical of the type "R-S(0) 2 -" wherein "R" is an alkyl radical as defined above and "S(0) 2 " is a di-oxygenated sulfur atom. Examples of such alkylsulfonyl radicals include methylsulfonyl, ethylsulfonyl, n-propylsulfonyl , isopropylsulfonyl, n-butylsulfonyl, iso-butylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl and the like. "Aryl", alone or in combination, means a phenyl or biphenyl radical, which is optionally benzo fused or heterocyclo fused and which is optionally substituted with one or more substituents selected from alkyl, alkoxy, halogen, hydroxy, amino, azido, nitro, cyano, haloalkyl, carboxy, alkoxycarbonyl, cycloalkyl, alkanoylamino, amido, amidino, alkoxycarbonylamino, N- alkylamidino, alkylamino, dialkylamino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, N-alkylamido, N,N- dialkylamido, aralkoxycarbonylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, oxo and the like. Examples of aryl radicals are phenyl, o-tolyl, 4- methoxyphenyl , 2- (tert-butoxy) phenyl, 3-methyl-4- methoxyphenyl , 2-CF 3 -phenyl, 2-fluorophenyl, 2- chlorophenyl , 3-nitrophenyl, 3-aminophenyl, 3- acetamidophenyl , 2-amino-3- (aminomethyl) phenyl, 6- methyl-3-acetamidophenyl, 6-methyl-2-aminophenyl, 6- methyl-2 , 3-diaminophenyl, 2-amino-3-methyIphenyl, 4,6- dimethyl-2-aminophenyl, 4-hydroxyphenyl, 3-methyl-4- hydroxyphenyl , 4- (2-methoxyphenyl)phenyl, 2-amino-l- naphthyl, 2-naphthyl, 3-amino-2-naphthyl, l-methyl-3- amino-2-naphthyl, 2 , 3-diamino-l-naphthyl, 4 , 8-dimethoxy- 2-naphthyl and the like. "Aralkyl" and "arylalkyl", alone or in combination, means an alkyl radical as defined above in which at least one hydrogen atom, preferably 1-2, is replaced by an aryl radical as defined above, such as benzyl, 1-, 2- phenylethyl, dibenzylmethyl , hydroxyphenylmethyl , methylphenylmethyl , diphenylmethyl , dichlorophenylmethyl, 4-methoxyphenylmethyl and the like. "Aralkoxy" , alone or in combination, means an alkoxy radical as defined above in which at least one hydrogen atom, preferably 1-2, is replaced by an aryl radical as defined above, such as benzyloxy, 1-, 2-phenylethoxy, dibenzyl ethoxy, hydroxyphenylmethoxy, methylphenylmethoxy, dichlorophenylmethoxy, 4- methoxyphenylmethoxy and the like. "Aralkoxycarbonyl" , alone or in combination, means a radical of the type "R-O-C(O)-" wherein "R-0-" is an aralkoxy radical as defined above and "-C(O)-" is a carbonyl radical . "Alkanoyl", alone or in combination, means a radical of the type "R-C(O)-" wherein "R" is an alkyl radical as defined above and W -C(0)-" is a carbonyl radical. Examples of such alkanoyl radicals include acetyl, trifluoroacetyl, hydroxyacetyl, propionyl, butyryl, valeryl, 4-methylvaleryl, and the like. "Alkanoylamino", alone or in combination, means a radical of the type "R-C(0)-NH-" wherein "R-C(O)-" is an alkanoyl radical as defined above, wherein the amino radical may optionally be substituted, such as with alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl and the like. "Aminocarbonyl", alone or in combination, means an amino substituted carbonyl (carbamoyl) radical, wherein the amino radical may optionally be mono- or di-substituted, such as with alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, alkanoyl, alkoxycarbonyl, aralkoxycarbonyl and the like. "Aminosulfonyl", alone or in combination, means an amino substituted sulfonyl radical. "Benzo", alone or in combination, means the divalent radical C δ H 4 = derived from benzene. "Benzo fused" forms a ring system in which benzene and a cycloalkyl or aryl group have two carbons in common, for example tetrahydronaphthylene and the like. "Bicyclic" as used herein is intended to include both fused ring systems, such as naphthyl and β-carbolinyl, and substituted ring systems, such as biphenyl, phenylpyridyl and diphenylpiperazinyl . "Cycloalkyl", alone or in combination, means a saturated or partially saturated, preferably one double bond, monocyclic, bicyclic or tricyclic carbocyclic alkyl radical, preferably monocyclic, containing preferably 5- 12 carbon atoms (C 5 -Cχ 2 ) , more preferably 5-10 carbon atoms (C 5 -C X0 ) , even more preferably 5-7 carbon atoms (C 5 -C 7 ) , which is optionally benzo fused or heterocyclo fused and which is optionally substituted as defined herein with respect to the definition of aryl. Examples of such cycloalkyl radicals include cyclopentyl, cyclohexyl, dihydroxycyclohexyl, ethylenedioxycyclohexyl, cycloheptyl, octahydronaphthyl , tetrahydronaphthyl , octahydroquinolinyl , dimethoxytetrahydronaphthyl , 2 , 3-dihydro-lH-indenyl, azabicyclo [3.2. l]octyl and the like. "Heteroatoms" means nitrogen, oxygen and sulfur heteroatoms . "Heterocyclo fused" forms a ring system in which a heterocyclyl or heteroaryl group of 5-6 ring members and a cycloalkyl or aryl group have two carbons in common, for example indole, isoquinoline, tetrahydroquinoline, methylenedioxybenzene and the like. "Heterocyclyl" means a saturated or partially unsaturated, preferably one double bond, monocyclic or bicyclic, preferably monocyclic, heterocycle radical containing at least one, preferably 1 to 4, more preferably 1 to 3 , even more preferably 1-2, nitrogen, oxygen or sulfur atom ring member and having preferably 3-8 ring members in each ring, more preferably 5-8 ring members in each ring and even more preferably 5-6 ring members in each ring. "Heterocyclyl" is intended to include sulfone and sulfoxide derivatives of sulfur ring members and N-oxides of tertiary nitrogen ring members, and carbocyclic fused, preferably 3-6 ring carbon atoms and more preferably 5-6 ring carbon atoms, and benzo fused ring systems. "Heterocyclyl" radicals may optionally be substituted on at least one, preferably 1- 4, more preferably 1-3, even more preferably 1-2, carbon atoms by halogen, alkyl, alkoxy, hydroxy, oxo, thioxo, aryl, aralkyl, heteroaryl, heteroaralkyl, amidino, N- alkylamidino, alkoxycarbonylammo, alkylsulfonylamino and the like, and/or on a secondary nitrogen atom by hydroxy, alkyl, aralkoxycarbonyl , alkanoyl, alkoxycarbonyl, heteroaralkyl , aryl or aralkyl radicals. More preferably, "heterocyclyl", alone or in combination, is a radical of a monocyclic or bicyclic saturated heterocyclic ring system having 5-8 ring members per ring, wherein 1-3 ring members are oxygen, sulfur or nitrogen heteroatoms, which is optionally partially unsaturated or benzo-fused and optionally substituted by 1-2 oxo or thioxo radicals. Examples of such heterocyclyl radicals include pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiamorpholmyl, 4-benzyl-piperazin-l-yl, pyrimidinyl, tetrahydrofuryl, pyrazolidonyl, pyrazolinyl, pyridazinonyl, pyrrolidonyl, tetrahydrothienyl and its sulfoxide and sulfone derivatives, 2 , 3-dihydroindolyl , tetrahydroquinolinyl , 1, 2, 3 , 4-tetrahydroisoquinolinyl, 1 , 2 , 3 , 4-tetrahydro-l- oxo-isoquinolinyl, 2 , 3-dihydrobenzofuryl , benzopyranyl , methylenedioxyphenyl, ethylenedioxyphenyl and the like. "Heteroaryl" means a monocyclic or bicyclic, preferably monocyclic, aromatic heterocycle radical, having at least one, preferably 1 to 4, more preferably 1 to 3 , even more preferably 1-2, nitrogen, oxygen or sulfur atom ring members and having preferably 5-6 ring members in each ring, which is optionally saturated carbocyclic fused, preferably 3-4 carbon atoms (C -C 4 ) to form 5-6 ring membered rings and which is optionally substituted as defined above with respect to the definitions of aryl . Examples of such heteroaryl groups include imidazolyl, l-benzyloxycarbonylimidazol-4-yl, pyrrolyl, pyrazolyl, pyridyl, 3- (2-methyl)pyridyl, 3- (4- trifluoromethyl)pyridyl, pyrimidinyl, 5- (4- trifluoromethyl)pyrimidinyl, pyrazinyl, triazolyl, furyl, thienyl, oxazolyl, thiazolyl, indolyl, quinolinyl , 5,6,7, 8-tetrahydroquinolyl , 5, 6, 7, 8-tetrahydroisoquinolinyl, quinoxalinyl, benzothiazolyl, benzofuryl, benzimidazolyl, benzoxazolyl and the like. "Heteroaralkyl" and "heteroarylalkyl," alone or in combination, means an alkyl radical as defined above in which at least one hydrogen atom, preferably 1-2, is replaced by a heteroaryl radical as defined above, such as 3-furylpropyl, 2-pyrrolyl propyl, chloroquinolinylmethyl, 2-thienylethyl, pyridylmethyl , 1-imidazolylethyl and the like. "Halogen" and "halo", alone or in combination, means fluoro, chloro, bromo or iodo radicals. "Haloalkyl", alone or in combination, means an alkyl radical as defined above in which at least one hydrogen atom, preferably 1-3, is replaced by a halogen radical, more preferably fluoro or chloro radicals . Examples of such haloalkyl radicals include 1, 1, 1-trifluoroethyl, chloromethyl, 1-bromoethyl, fluoromethyl, difluoromethyl, trifluoromethyl, bis (trifluoromethyl) ethyl and the like. "Pharmacologically acceptable salt" means a salt prepared by conventional means, and are well known by those skilled in the art. The "pharmacologically acceptable salts" include basic salts of inorganic and organic acids, including but not limited to hydrochloric acid, hydrobromic acid, sulphuric acid, phosphoric acid, methanesulphonic acid, ethanesulfonic acid, malic acid, acetic acid, oxalic acid, tartaric acid, citric acid, lactic acid, fumaric acid, succinic acid, maleic acid, salicylic acid, benzoic acid, phenylacetic acid, mandelic acid and the like. When compounds of the invention include an acidic function such as a carboxy group, then suitable pharmaceutically acceptable cation pairs for the carboxy group are well known to those skilled in the art and include alkaline, alkaline earth, ammonium, quaternary ammonium cations and the like. For additional examples of "pharmacologically acceptable salts," see infra and Berge et al, J. Pharm . Sci . 66, 1 (1977) . "Cytokine" means a secreted protein that affects the functions of other cells, particularly as it relates to the modulation of interactions between cells of the immune system or cells involved in the inflammatory response. Examples of cytokines include but are not limited to interleukin 1 (IL-1) , preferably IL-lβ, interleukin 6 (IL-6) , interleukin 8 (IL-8) and TNF, preferably TNF-α (tumor necrosis factor-α) . "TNF, IL-1, IL-6, and/or IL-8 mediated disease or disease state" means all disease states wherein TNF, IL- 1, IL-6, and/or IL-8 plays a role, either directly as TNF, IL-1, IL-6, and/or IL-8 itself, or by TNF, IL-1, IL-6, and/or IL-8 inducing another cytokine to be released. For example, a disease state in which IL-1 plays a major role, but in which the production of or action of IL-1 is a result of TNF, would be considered mediated by TNF. "Leaving group" generally refers to groups readily displaceable by a nucleophile, such as an amine, a thiol or an alcohol nucleophile. Such leaving groups are well known in the art. Examples of such leaving groups include, but are not limited to, N-hydroxysuccinimide, N-hydroxybenzotriazole, halides, triflates, tosylates and the like. Preferred leaving groups are indicated herein where appropriate . "Protecting group" generally refers to groups well known in the art which are used to prevent selected reactive groups, such as carboxy, amino, hydroxy, mercapto and the like, from undergoing undesired reactions, such as nucleophilic, electrophilic, oxidation, reduction and the like. Preferred protecting groups are indicated herein where appropriate. Examples of amino protecting groups include, but are not limited to, aralkyl, substituted aralkyl, cycloalkenylalkyl and substituted cycloalkenyl alkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl , silyl and the like. Examples of aralkyl include, but are not limited to, benzyl, ortho- methylbenzyl , trityl and benzhydryl, which can be optionally substituted with halogen, alkyl, alkoxy, hydroxy, nitro, acylamino, acyl and the like, and salts, such as phosphonium and ammonium salts . Examples of aryl groups include phenyl, naphthyl, indanyl, anthracenyl, 9- ( 9-phenylfluorenyl ) , phenanthrenyl , durenyl and the like. Examples of cycloalkenylalkyl or substituted cycloalkylenylalkyl radicals, preferably have 6-10 carbon atoms, include, but are not limited to, cyclohexenyl methyl and the like. Suitable acyl, alkoxycarbonyl and aralkoxycarbonyl groups include benzyloxycarbonyl, t- butoxycarbonyl , iso-butoxycarbonyl, benzoyl, substituted benzoyl, butyryl, acetyl, tri-fluoroacetyl, tri-chloro acetyl, phthaloyl and the like. A mixture of protecting groups can be used to protect the same amino group, such as a primary amino group can be protected by both an aralkyl group and an aralkoxycarbonyl group . Amino protecting groups can also form a heterocyclic ring with the nitrogen to which they are attached, for example, 1, 2-bis (methylene) benzene, phthalimidyl, succinimidyl , maleimidyl and the like and where these heterocyclic groups can further include adjoining aryl and cycloalkyl rings. In addition, the heterocyclic groups can be mono-, di- or tri-substituted, such as nitrophthalimidyl . Amino groups may also be protected against undesired reactions, such as oxidation, through the formation of an addition salt, such as hydrochloride, toluenesulfonic acid, trifluoroacetic acid and the like. Many of the amino protecting groups are also suitable for protecting carboxy, hydroxy and mercapto groups. For example, aralkyl groups. Alkyl groups are also sutiable groups for protecting hydroxy and mercapto groups, such as tert- butyl . Silyl protecting groups are silicon atoms optionally substituted by one or more alkyl, aryl and aralkyl groups. Suitable silyl protecting groups include, but are not limited to, trimethylsilyl, triethylsilyl, tri-isopropylsilyl, tert- butyldimethylsilyl, dimethylphenylsilyl, 1,2- bis (dimethylsilyl) benzene, 1, 2-bis (dimethylsilyl) ethane and diphenylmethylsilyl. Silylation of an amino groups provide mono- or di-silylamino groups. Silylation of aminoalcohol compounds can lead to a N,N, O-tri-silyl derivative. Removal of the silyl function from a silyl ether function is readily accomplished by treatment with, for example, a metal hydroxide or ammonium flouride reagent, either as a discrete reaction step or in situ during a reaction with the alcohol group. Suitable silylating agents are, for example, trimethylsilyl chloride, tert-buty-dimethylsilyl chloride, phenyldimethylsilyl chloride, diphenylmethyl silyl chloride or their combination products with imidazole or DMF . Methods for silylation of amines and removal of silyl protecting groups are well known to those skilled in the art. Methods of preparation of these amine derivatives from corresponding amino acids, amino acid amides or amino acid esters are also well known to those skilled in the art of organic chemistry including amino acid/amino acid ester or aminoalcohol chemistry. Protecting groups are removed under conditions which will not affect the remaining portion of the molecule. These methods are well known in the art and include acid hydrolysis, hydrogenolysis and the like. A preferred method involves removal of a protecting group, such as removal of a benzyloxycarbonyl group by hydrogenolysis utilizing palladium on carbon in a suitable solvent system such as an alcohol, acetic acid, and the like or mixtures thereof. A t-butoxycarbonyl protecting group can be removed utilizing an inorganic or organic acid, such as HCl or trifluoroacetic acid, in a suitable solvent system, such as dioxane or methylene chloride. The resulting amino salt can readily be neutralized to yield the free amine. Carboxy protecting group, such as methyl, ethyl, benzyl, tert-butyl, 4- methoxyphenylmethyl and the like, can be removed under hydroylsis and hydrogenolysis conditions well known to those skilled in the art. The symbols used above have the following meanings : -NR X R y Procedures for preparing the compounds of this invention are set forth below. It should be noted that the general procedures are shown as it relates to preparation of compounds having unspecified stereochemistry. However, such procedures are generally applicable to those compounds of a specific stereochemistry, e.g., where the stereochemistry about a group is (S) or (R) . In addition, the compounds having one stereochemistry (e.g., (R) ) can often be utilized to produce those having opposite stereochemistry (i.e., (S) ) using well-known methods, for example, by inversion. Preparation of Compounds of Formula I The compounds of the present invention represented by Formula I above can be prepared utilizing the following general procedures . Hetero-aromatic Nitrogen Compounds; Pyrroles and Pyridines : Schofield, Kenneth; Plenum Press, New York, NY; (1967) and Advances in Nitrogen Heterocvcles : JAI Press, Greenwich, CN; (1995) describe procedures and references that may be useful in preparing compounds of the present invention. 2-Halo-5-nitro-pyridine analogs (2) can be treated with the appropriate a ine, alcohol, phenol, or thiol (R^X-H) in the presence of base or Cu(I) in an appropriate solvent, such as THF, DMF, DME, DMSO and the like, at a temperature from -20°C to 120°C to form 2- substituted-5-nitropyridines (3) (Scheme I). Reduction of the nitro group can be perfomed by treatment of (3) with hydrogen gas in the presence of palladium on carbon or Raney nickel, or alternatively, by treatment with SnCl 2 in an alcoholic solvent and in the presence or absence of HCl to obtain 2-substituted-5-aminopyridines (4) . The aminopyridines (4) may be alkylated using alkylhalides and an appropriate base or by reductive alkylation employing the appropriate aldehyde or ketone in the presence of a reducing agent, such as sodium triacetoxy borohydride, borane«THF and the like, to form the substituted aminopyridines (5) . Either (4) or (5) may be acylated with an appropriate acid halide (e.g., R 3 C(0)C1 or R 3 C(0)Br) in the presence of a base, such as pyridine, DMAP and the like, or alternatively may be acylated with an anhydride, either mixed or symmetrical, or alternatively may be acylated by treatment with the appropriate acid (R 3 C0 2 H) in the presence of a coupling agent such as a carbodiimide reagent to form the final product (1) . Alternatively, substituted 2-bromo-5- nitropyridine analogs may be reduced to, substituted 2- bromo-5-aminopyridine analogs by the action of SnBr 2 in methanolic solvent. Subsequent acylation with an appropriate activated ester (i.e.: R 3 C0 2 H in the presence of diisopropylcarbodiimide in methylene chloride as solvent) produces 2-bromopyridine-5-carboxamide compounds of structure (5a) . Coupling of (5a) with an appropriate phenol in the presence of Cu(Ac) 2 and K 2 C0 3 in DMF at 140°C provides compounds of formula (1) where X = 0. SCHEME I ( i : ( 5a) 6-Substituted-2-halo-5-nitro-pyridine analogs (6) may be prepared from 2 , 6-dichloro-5-nitropyridine according to the methods outlined in Scheme II. Treatment with one equivalent of an appropriate nucleophile of R 7 or a precursor thereof (such as, HO " , RO " , AcS " , NC " , RS " and the like) provides (6) . Subsequent reaction to form (7) (treatment with R^X-H in the presence of base or Cu(I) in an appropriate solvent, such as THF, DMF, DME, DMSO and the like, at a temperature from -20°C to 120°C) and (8) (reduction of the nitro group and substitution with R 4 ) is as described in Scheme I (cf. Colbry, N.L. et al . ; J. Heterocyclic Chem., 21: 1521-1525 (1984); Matsumoto, Jun-ichi, et al . ; J. Heterocyclic Chem., 21 : 673-679 (1984)) . (8) may be reacted with an acid halide or an activated SCHEME II 1 ) ester as shown in Scheme I to provide compounds of formula ( 1 ) . Where R 7 = CN, compounds of formula ( 8 ! may be hydrolyzed to acids (R 7 = C0 2 H) of formula (9) using acidic media such as HBr and the like. Utilizing the appropriate N-protecting groups, acids of formula (9) may be transformed into esters, amides and alcohols. Compounds of formula (9) and derivatives described above may be be reacted with an acid halide or an activated ester as shown in Scheme I to provide compounds of formula (1). Compounds of formula (8), where R 7 = -CN, may be reduced to the primary amine (R 7 = -CH 2 NH 2 ) using reagents such as BH 3 or hydrogen gas in the presence of palladium on carbon or Raney nickel . Subsequent manipulation and reaction of the primary amine may be performed in the presence of the pyridine-5-amine substituent due to it's greater reactivity. Specifically, compounds of formula (8) where R 7 = -CH 2 NH 2 may be alkylated by treatment with an appropriate aldehyde or ketone in the presence of a reducing agent, such as sodium triacetoxy borohydride, or may be acylated by treatment with an appropriate activated ester, chloroformate, isocyanate and the like, or may be sulfonylated by treatment with an appropriate sulfonyl halide. Alternatively, substituted 3-aminopyridine intermediates may be prepared from the corresponding nicotinamide compound using Hofmann'ε reaction. When R 6 and/or R 7 is an alkyl group, such as methyl, in compound (7) , containing the appropriate protecting groups of or avoiding the presence of base sensitive groups, can be treated with strong base such as NaNH 2 , PhLi, NaH or the like at temperatures from -78°C to 22°C then treated with electrophiles, such as alkyl halides, aldehydes, ketones and the like (cf. Fuerst, Feustel; CHEMTECH: 1H: 693-699 (1958); Nishigaki, S. et al.; Chem. Pharm. Bull.; 17: 1827-1831 (1969); Kaiser, Edwin M. ; Tetrahedron; 3_9: 2055-2064 (1983)). Alternatively, the alkyl group may be halogenated and the haloalkyl group may be reacted with a nucleophile, such as an amino group, alkoxy, alkylthiol and the like. 6-Chloronicotinoyl chloride analogs (10) are treated with the appropriate amine (R 3 R 4 NH) in the presence of base in an appropriate solvent, such as dichloromethane, acetonitrile, DMF, THF and the like, at a temperature from -20°C to 120°C to form nicotinamides (11) as shown in Scheme III. Alternatively, 6- chloronicotinic acid analogs (12) may be coupled with the appropriate amine via an anhydride, either mixed or symmetrical, or alternatively by treatment with the appropriate amine in the presence of a coupling agent such as a carbodiimide reagent to form the amide (11) . 6-Chloronicotinamide analogs (11) are treated with the appropriate R^X-H in the presence of absence of base, or Cu(I) in an approriate solvent, such as pyridine, ethylene glycol, DMF, DME, DMSO and the like, at a temperature from -20°C to 180°C to form the final product (13 ) . SCHEME II I Substituted halopyridines may be readily prepared from the corresponding pyridones using phosphorus oxychloride or pentachloride. Amines of formula NHR : R 2 and NHR 3 R 4 are commercially available or can be readily prepared by those skilled in the art from commercially available starting materials. For example, an amide, nitro or cyano group can be reduced under reducing conditions, such as in the prescence of a reducing agent like lithium aluminum hydride and the like, to form the corresponding amine. Alkylation and acylation of amino groups are well known in the art. Chiral and achiral substituted amines can be prepared from chiral amino acids and amino acid amides (for example, alkyl, aryl, heteroaryl, cycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl and the like) using methods well known in the art, such as H. Brunner, P. Hankofer, U. Holzinger, B. Treittinger and H. Schoenenberger, Eur. J. Med. Chem. 25, 35-44, 1990; M. Freiberger and R. B. Hasbrouck, J. Am. Chem. Soc. 82, 696-698, 1960; Dornow and Fust, Chem. Ber. 87, 984, 1954; M. Kojima and J. Fujita, Bull. Chem. Soc. Jpn. 55, 1454-1459, 1982; W. Wheeler and D. O'Bannon, Journal of Labelled Compounds and Radiopharmaceuticals XXXI, 306, 1992; and S. Davies, N. Garrido, 0. Ichihara and I. Walters, J. Chem. Soc, Chem. Commun. 1153, 1993. Alkyl sulfonic acids, aryl sulfonic acids, heterocyclyl sulfonic acids, heteroaryl sulfonic acids, alkylmercaptans, arylmercaptans, heterocyclylmercaptans, heteroarylmercaptans , alkylhalides, arylhalides, heterocyclylhalides, heteroarylhalides, and the like are commercially available or can be readily prepared from starting materials commercially available using standard methods well known in the art. Thioether derivatives can be converted into the corresponding sulfone or sulfoxide by oxidizing the thioether derivative with a suitable oxidation agent in a suitable solvent. Suitable oxidation agents include, for example, hydrogen peroxide, sodium meta-perborate, oxone (potassium peroxy monosulfate) , meta- chloroperoxybenzoic acid, periodic acid and the like, including mixtures thereof. Suitable solvents include acetic acid (for sodium meta-perborate) and, for other peracids, ethers such as THF and dioxane, and acetonitrile, DMF and the like, including mixtures thereof . The chemical reactions described above are generally disclosed in terms of their broadest application to the preparation of the compounds of this invention. Occasionally, the reactions may not be applicable as described to each compound included within the disclosed scope. The compounds for which this occurs will be readily recognized by those skilled in the art. In all such cases, either the reactions can be successfully performed by conventional modifications known to those skilled in the art, e.g., by appropriate protection of interfering groups, by changing to alternative conventional reagents, by routine modification of reaction conditions, and the like, or other reactions disclosed herein or otherwise conventional, will be applicable to the preparation of the corresponding compounds of this invention. In all preparative methods, all starting materials are known or readily prepared from known starting materials. Prodrugs of the compounds of this invention are also contemplated by this invention. A prodrug is an active or inactive compound that is modified chemically through in vivo physicological action, such as hydrolysis, metabolism and the like, into a compound of this invention following adminstration of the prodrug to a patient. The suitability and techniques involved in making and using prodrugs are well known by those skilled in the art. For a general discussion of prodrugs involving esters see Svensson and Tunek Drug Metabolism Reviews 165 (1988) and Bundgaard Design of Prodrugs, Elsevier (1985) . Examples of a masked carboxylate anion include a variety of esters, such as alkyl (for example, methyl, ethyl) , cycloalkyl (for example, cyclohexyl), aralkyl (for example, benzyl, p- methoxybenzyl) , and alkylcarbonyloxyalkyl (for example, pivaloyloxymethyl) . Amines have been masked as arylcarbonyloxymethyl substituted derivatives which are cleaved by esterases in vivo releasing the free drug and formaldehyde (Bungaard J. Med. Chem. 2503 (1989)). Also, drugs containing an acidic NH group, such as imidazole, imide, indole and the like, have been masked with N-acyloxymethyl groups (Bundgaard Design of Prodrugs, Elsevier (1985)). Hydroxy groups have been masked as esters and ethers. EP 039,051 (Sloan and Little, 4/11/81) discloses Mannich-base hydroxamic acid prodrugs, their preparation and use. Without further elaboration, it is believed that one skilled in the art can, using the preceding description, utilize the present invention to its fullest extent. The following preferred specific embodiments are, therefore, to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever. The following Examples illustrate the preparation of compounds of the present invention and intermediates useful in preparing the compounds of the present invention. Example 1 Preparation of 2- (4-Chloro-2x-methyl-phenoxy) -5-amino- pyridine Step A: 2- (4-Chloro-2-methyl-phenoxy) -5-nitropyridine 4-Chloro-2-methylphenol (101 mg, 0.71 mmol) was dissolved in tetrahydrofuran (2.1 mL) and the solution was treated with sodium hydride (60% dispersed in mineral oil, 31 mg, 0.78 mmol). After stirring for 30 minutes at 22°C, 2-chloro-5-nitropyridine (101 mg, 0.64 mmol) was added and the reaction mixture was heated to reflux for 1 hour. The solution was cooled to ambient temperature, quenched with saturated aqueous NH 4 C1 and concentrated in vacuo . The residue was redissolved in ethyl acetate then washed 2x with saturated NaHC0 3 , saturated NaCl, dried over anhydrous Na 2 S0 4 and concentrated in vacuo . Step B: 2- (4-Chloro-2-methyl-phenoxy) -5-amino-Pyridine 2- (4-chloro-2-methyl-phenoxy) -5-nitropyridine (203 mg, 0.77 mmol) was dissolved in 95% ethanol (3 mL) and treated with 20% palladium hydroxide on carbon (50 mg) . The reaction mixture was shaken in a hydrogen atmosphere (40 psi) for 1 hour. The solution was filtered through celite and concentrated in vacuo . MS (m/z) -. 234/236 (M+H) + ; C 12 H U N 2 0C1 requires 234.7. Example 2 The compounds listed in Table 1 were prepared from 2-chloro-5-nitropyridine and the appropriate alcohol, amine or thiol in the same manner as 2- (4-Chloro-2- methyl-phenoxy) -5-amino-pyridine was prepared. Table 1 MS (m/z) 2- (4-Chloro-2-methylphenoxy) -5-amino-pyridine 235 2- (4-Chloro-2, 6-dimethylphenoxy) -5-amino- 249 pyridine 2- (2-Methyl-pyridin-3-yloxy) -5-amino-pyridine 201 2- (4-Fluoro-2-methylphenoxy) -5-amino-pyridine 218 2- (2-Isopropylphenoxy) -5-amino-pyridine 228 2- (1-Naphthyloxy) -5-amino-pyridine 236 2- (Cyclohexyloxy) -5-amino-pyridine 192 2- (2-Methylphenoxy) -5-amino-pyridine 200 2- (2, 4-Dimethylphenoxy) -5-amino-pyridine 214 2- (4-Chlorophenoxy) -5-amino-pyridine 222 2- (Phenoxy) -5-amino-pyridine 186 2- (2-Methylcyclohexylamino) -5-amino-pyridine 205 2- (Cyclohexylamino) -5-amino-pyridine 191 2- (2-Methylanilino) -5-amino-pyridine 199 2- (4-Chloro-2-methylanilino) -5-amino-pyridine 233 2- (2 , 4-Dimethylanilino) -5-amino-pyridine 212 2- (4-Chloro-2-methylthiophenoxy) -5-amino- 251 pyridine Example 3 Preparation of 2- (4-Chloro-2-methyl-phenoxy) -3-methyl-5- amino-pyridine Step A: 2- (4-Chloro-2-methyl-phenoxy) -3-methyl-5- nitropyridine Sodium hydride (60% in mineral oil, 1.08 g, 27 mmol) was washed 3x with hexanes then a solution of 4-chloro-2- methylphenol (3.50 g, 24.5 mmol) dissolved in tetrahydrofuran (40 mL) was added. The solution was stirred for 20 minutes then 2-chloro-3-methyl-5- nitropyridine (4.02 g, 23.3 mmol) was added and the reaction mixture was heated to reflux for 3 hours. After cooling, the mixture was concentrated in vacuo then dissolved in ethyl acetate and washed with water, 3x with saturated NaHC0 3 and saturated NaCl then dried over Na 2 S0 4 and concentrated in vacuo. Step B: 2- (4-Chloro-2-methyl-phenoxy) -3-methyl-5-amino- pyridine 2- (4-chloro-2-methyl-phenoxy) -3-methyl-5-nitropyridine (5.8 g, 20.8 mmol) was dissolved in 95% ethanol (50 mL) and treated with 20% palladium hydroxide on carbon (350 mg) . The reaction mixture was shaken in a hydrogen atmosphere (40 psi) for 1 hour. The solution was filtered through celite and concentrated in vacuo followed by chromatography on Si0 2 using 1:1 ethyl acetate / hexanes as eluant. MS (m/z) : 248/250 (M+H) * ; C 13 H 13 N 2 0C1 requires 248.7. Example 4 The compounds listed in Table 2 were prepared from substituted 2-chloro-5-nitropyridine and 4-chloro-2- methylphenol in the same manner as 2- (4-Chloro-2-methyl- phenoxy) -3-methyl-5-amino-pyridine was prepared. Table 2 MS (m/z) 2- (4-Chloro-2-methyl-phenoxy) -4-methyl-5-amino- 249 pyridine 6- (4-Chloro-2-methyl-phenoxy) -2-methyl-3-amino- 249 pyridine 6- (4-Chloro-2-methyl-phenoxy) -2 , 3-diamino- 250 pyridine Preparation of N- (2- (4-Chloro-2-methyl-phenoxy) -pyridin- 5-yl) -benzamide 2- (4-Chloro-2-methyl-phenoxy) -5-aminopyridine (211 mg, 0.90 mmol) was dissolved in methylene chloride (2.7 mL) then treated with triethylamine (0.19 mL, 1.35 mmol) followed by benzoyl chloride (0.13 L, 1.12 mmol). The reaction mixture was stirred for 3 hours at 22°C then saturated aqueous NaHC0 3 was added and the mixture was stirred for another hour. The organic layer was separated and washed 2x with 6% aqueous NaHC0 3 , dried over Na 2 S0 4 and concentrated in vacuo. The residue was chromatographed on silica gel using 1:1 ethyl acetate / hexane as eluent. The product was recovered as a white solid. MS (m/z) : 338/340 (M+H) * ; C 19 H 15 N 2 0 2 C1 requires 338.8. Example 6 The compounds listed in Table 3 were prepared from substituted 5-aminopyridine compounds and the appropriate acid chloride in the same manner as N-(2-(4- Chloro-2-methyl-phenoxy) -pyridin-5-yl) -benzamide was prepared. Table 3 MS (m/z) 2-(4-Chloro-2-methyl-phenoxy)-5-(3- 340 pyridylcarbonylamino) pyridine 2-(4-Chloro-2-methyl-phenoxy)-5- ( (2,6- 408 dichlorophenyl) carbonylamino)pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- (4- 340 pyridylcarbonylamino) pyridine 2- ( 4-Chloro-2-methyl-phenoxy) -5- ( (4- 369 methoxyphenyl ) carbonylamino)pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- ( (4- 409 pentyIphenyl ) carbonylamino) pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- (2- 389 naphthylcarbonylamino)pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- (2- 345 thienylcarbonylamino)pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- ( (3 , 5-dimethyl- 358 4-isoxazolyl) carbonylamino)pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- ( (5- 383 benzo [1,3] dioxol-yl) carbonylamino) pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- ( (5- tert-butyl- 399 2-methyl-2H-pyrazol-3-yl) carbonylamino)pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- ( (2- 395 benzo [J] thiophenyl ) carbonylamino)pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- ( (2- 369 methoxyphenyl) carbonylamino)pyridine 2- (4-Chloro-2-methyl-phenoxy)-5-( (3,5- 408 dichlorophenyl) carbonylamino)pyridine 2- (4-Chloro-2-methyl-phenoxy)-5-( (2,6- 367 dimethylphenyl) carbonylamino)pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- ( (2- 353 methyIphenyl ) carbonylamino)pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- ( (2- 384 nitrophenyl) carbonylamino)pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- ( (2- 397 acetoxyphenyl ) carbonylamino)pyridine 2-(4-chloro-2,6-dimethylphenoxy)-5-( (2,6- 422 dichlorophenyl) carbonylamino)pyridine 2-(4-chloro-2,6-dimethylphenoxy)-5-( (2,6- 381 dimethyIphenyl ) carbonylamino) pyridine 2-(2-methyl-pyridin-3-yloxy)-5-( (2,6- 374 dichlorophenyl) carbonylamino)pyridine 2- (2-methyl-pyridin-3-yloxy)-5- ( (2,6- 333 dimethyIphenyl ) carbonylamino) pyridine 2- (2-methyl-pyridin-3-yloxy) -5-((2- 319 methylphenyl) carbonylamino)pyridine 2- (4-fluoro-2-methylphenoxy)-5- ((2,6- 391 dichlorophenyl ) carbonylamino) pyridine 2- (4-fluoro-2-methylphenoxy)-5- ((2,6- 350 dimethylphenyl ) carbonylamino) pyridine 2- (4-fluoro-2-methylphenoxy) -5- ( (2- 336 methylphenyl ) carbonylamino)pyridine 2- (4-fluoro-2-methylphenoxy) -5- ( (2- 390 trifluoromethylphenyl) carbonylamino)pyridine 2- (4-fluoro-2-methylphenoxy) -5- ( (2- 340 fluorophenyl ) carbonylamino)pyridine 2- (2-isopropylphenoxy)-5- ( (2,6- 401 dichlorophenyl) carbonylamino)pyridine 2- (2-isopropylphenoxy) -5- ((2,6- 360 dimethylphenyl ) carbonylamino) pyridine 2- (2-isopropylphenoxy) -5- ( (2- 346 methylphenyl) carbonylamino)pyridine 2-(l-naphthyloxy)-5-( (2,6- 409 dichlorophenyl ) carbonylamino) pyridine 2-(l-naphthyloxy)-5-( (2,6- 368 dimethylphenyl) carbonylamino)pyridine 2-(l-naphthyloxy)-5-( (2- 354 methylphenyl ) carbonylamino)pyridine 2- (cyclohexyloxy)-5-( (2,6- 365 dichlorophenyl) carbonylamino) pyridine 2-(cyclohexyloxy)-5- ( (2,6- 324 dimethylphenyl) carbonylamino)pyridine 2-(cyclohexyloxy)-5-( (2- 331 chlorophenyl ) carbonylamino) pyridine 2- (cyclohexyloxy)-5- ( (2- 310 methylphenyl) carbonylamino)pyridine 2-(2-methylphenoxy)-5- ( (2,6- 373 dichlorophenyl ) carbonylamino) pyridine 2- (2-methylphenoxy)-5- ( (2,6- 332 dimethylphenyl ) carbonylamino) pyridine 2- (2-methylphenoxy)-5- ( (2- 339 chlorophenyl) carbonylamino)pyridine 2- (2-methylphenoxy) -5- ( (2- 318 methylphenyl ) carbonylamino) pyridine 2-(2,4-dimethylphenoxy)-5-( (2, 6- 387 dichlorophenyl ) carbonylamino)pyridine 2-(2,4-dimethylphenoxy)-5- ( (2,6- 346 dimethylphenyl) carbonylamino)pyridine 2- (2,4-dimethylphenoxy)-5-( (2- 353 chlorophenyl ) carbonylamino)pyridine 2- (2,4-dimethylphenoxy)-5-( (2- 332 methylphenyl ) carbonylamino)pyridine 2-(4-chlorophenoxy)-5-( (2,6- 394 dichlorophenyl) carbonylamino)pyridine 2-(4-chlorophenoxy)-5-( (2,6- 353 dimethylphenyl) carbonylamino) pyridine 2- (2-methylcyclohexylamino) -5- ((2,6- 378 dichlorophenyl ) carbonylamino) pyridine 2- (2-methylcyclohexylamino) -5- ( (2- 323 methylphenyl) carbonylamino)pyridine 2- (cyclohexylamino)-5-( (2,6- 364 dichlorophenyl) carbonylamino)pyridine 2- (cyclohexylamino) -5- ( (2, 6- 323 dimethylphenyl) carbonylamino)pyridine 2- (cyclohexylamino) -5- ( (2- 309 methylphenyl ) carbonylamino) pyridine 2-(2-methylanilino)-5-( (2,6- 372 dichlorophenyl ) carbonylamino) pyridine 2- (2-methylanilino)-5-( (2,6- 331 dimethylphenyl) carbonylamino)pyridine 2- (2-methylanilino)-5-( (2- 317 methylphenyl ) carbonylamino) pyridine 2- (4-chloro-2-methylanilino)-5-( (2,6- 407 dichlorophenyl ) carbonylamino) pyridine 2- (4-chloro-2-methylanilino)-5- ((2,6- 366 dimethylphenyl ) carbonylamino) pyridine 2- (4-chloro-2-methylanilino) -5- ( (2- 352 methylphenyl ) carbonylamino)pyridine 2- (2,4-dimethylanilino) -5- ((2,6- 386 dichlorophenyl ) carbonylamino) yridine 2- (2,4-dimethylanilino)-5-( (2,6- 345 dimethylphenyl ) carbonylamino) pyridine 2- (2,4-dimethylanilino)-5- ( (2- 331 methylphenyl ) carbonylamino) pyridine 2- (2,4-dimethylanilino)-5-( (2- 352 chlorophenyl ) carbonylamino) pyridine 2- (2,4-dimethylanilino)-5-( (2- 335 fluorophenyl ) carbonylamino) pyridine 2-(4-chloro-2-methyl-thiophenyl)-5-( (2,6- 424 dichlorophenyl) carbonylamino)pyridine 2- ( 4-chloro-2-methyl-thiophenyl) -5- ( (2, 6- 383 dimethylphenyl ) carbonylamino) pyridine 2- (4-chloro-2-methyl-thiophenyl) -5- ( (2- 369 methylphenyl ) carbonylamino) pyridine Example 7 The compounds listed in Table 4 were prepared from substituted 5-aminopyridine compounds and the appropriate acid chloride in the same manner as N-(2-(4- Chloro-2-methyl-phenoxy) -pyridin-5-yl) -benzamide was prepared. Table 4 MS (m/ z ) 2-(4-Chloro-2-methyl-phenoxy)-5-( (2,6- 422 dichlorophenyl) carbonylamino) -3-methyl-pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- ( (2- 387 chlorophenyl) carbonylamino) -3-methyl-pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- ( (2- 367 methylphenyl) carbonylamino) -3-methyl-pyridine 2- (4-Chloro-2-methyl-phenoxy)-5-( (2,6- 332 dimethylphenyl) carbonylamino) -3-methyl-pyridine 2- (4-Chloro-2-methyl-phenoxy)-5-( (2,6- 422 dichlorophenyl) carbonylamino) -4-methyl-pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- ( (2-fluoro-6- 439 trifluoromethylphenyl) carbonylamino) -4-methyl- pyridine 2-(4-Chloro-2-methyl-phenoxy)-5-( (2,4,6- 479 triisopropyIphenyl) carbonylamino) -4-methyl- pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- ( (2- 367 methylphenyl) carbonylamino) -6-methyl-pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- ( (2- 387 chlorophenyl) carbonylamino) -6-methyl-pyridine 2-(4-Chloro-2-methyl-phenoxy)-5-( (2,6- 422 dichlorophenyl) carbonylamino) -6-methyl-pyridine 2- (4-Chloro-2-methyl-phenoxy) -5- ( (2,6- 423 dichlorophenyl) carbonylamino) -6-amino-pyridine 2-(4-Chloro-2-methyl-phenoxy)-5-( (2- 388 chlorophenyl) carbonylamino) -6-amino-pyridine 2-(4-Chloro-2-methyl-phenoxy)-5-( (2,6- 382 dimethylphenyl) carbonylamino) -6-amino-pyridme 2- (4-Chloro-2-methyl-phenoxy) -5- ( (2- 368 methylphenyl) carbonylamino) -6-amino-pyridine Example 8 Preparation of 2-Amino-N- (6- (4-chloro-2-methyl-phenoxy) - pyridin-3-yl) -benzamide N- (6- (4-chloro-2-methyl-phenoxy) -pyridin-3-yl) -2-nitro- benzamide (301 mg, 0.7 mmol) was dissolved in 95% ethanol (4 mL) and treated with 20% palladium hydroxide on carbon (Pearlman's catalyst, 50 mg) and subjected to a hydrogen atmosphere (40 psi) for 2 hours. The catalyst was removed by filtration and the solvents were removed in vacuo . The product was purified by chromatography on Si02 using 1:1 ethyl acetate / hexanes as eluent. MS (m/z) : 353/355 (M+H) * ; C 19 H 16 N 3 0 2 C1 requires 353.8. Preparation of N- (6- (4-chloro-2-methyl-phenoxy) -pyridin- 3-yl) -2-hydroxy-benzamide Acetic acid 2- (6- (4-chloro-2-methyl-phenoxy) -pyridin-3- ylcarbamoyl) -phenyl ester (304 mg, 0.77 mmol) dissolved in tetrahydrofuran (3.8 L) was treated with an aqueous lithium hydroxide solution (1.0 M, 3.8 mL, 3.8 mmol). The solution was stirred for 30 minutes at 22°C then quenched with aqueous saturated NH 4 C1. The mixture was diluted with ethyl acetate then the organics were washed with water, 2x saturated NaHC0 3 , saturated NaCl, dried over Na 2 S0 4 and concentrated in vacuo. MS (m/z) : 354/356 (M+H)\- C 19 H 15 N 2 0 3 C1 requires 354.8. Example 10 CH 3 Preparation of 2- (N-C eycloxhexyl-N-m..ethylamino) -5-amino- pyridine Step A: 2- (Cyclohexylamino) -5-nitro-pyridine Sodium hydride (60% dispersion in mineral oil, 1.99 g, 49.8 mmol) was washed 3x with hexanes then a solution of eyelohexylamine (3.8 mL, 33.2 mmol) dissolved in tetrahydrofuran (50 L) was added. After stirring for 30 minutes at 22 °C, 2-chloro-5-nitropyridine (5.00 g, 31.5 mmol) was added and the reaction mixture was heated to reflux for 3 hours . The solution was cooled to ambient temperature, quenched with saturated aqueous NH 4 C1 and concentrated in vacuo . The residue was redissolved in ethyl acetate then washed 2x with saturated NaHC0 3 , saturated NaCl, dried over anhydrous Na 2 S0 4 and concentrated in vacuo . The product was recovered as a brown oil. Step B: 2- (N-Cvclohexyl-N-methylamino) -5-nitro-pyridine Sodium hydride (60% dispersion in mineral oil, 0.38 g, 9.48 mmol) was washed 3x with hexanes then a solution of 2-cyclohexylamino-5-nitropyridine (1.88 g, 8.5 mmol) dissolved in dimethylformamide (20 L) was added. After stirring for 30 minutes at 22°C, the reaction mixture was cooled to 0°C and methyl iodide (0.55 mL, 8.9 mmol) was added. The solution was stirred for 1.5 hours at 0°C followed by quenching with saturated aqueous NH 4 C1. The reaction mixture was diluted with ethyl acetate and extracted 5x with water (200 mL) , saturated NaCl, dried over Na 2 S0 4 and concentrated in vacuo oil was chromatographed on Si0 2 using 2:1 hexanes / ethyl acetate as eluent. Step C: 2- (N-Cyclohexyl-N-methylamino) -5-amino-pyridine Cyclohexyl-methyl- (5-nitro-pyridin-2-yl) -amine (1.72 g, 7.3 mmol) was dissolved in ethanol (80 L) and treated with 20% palladium hydroxide on carbon (Pearlman's catalyst, 0.5 g) and the mixture was shaken under a hydrogen atmosphere (50 psi) for 6 hours. The catalyst was removed by filtration through celite then the filtrate was concentrated in vacuo and the resultant oil was chromotographed on Si0 2 using 1:1 ethyl acetate / hexanes as eluent. MS (m/z) : 206 (M+H) + ; C 12 H 19 N 3 requires 205.3. Example 11 Preparation of 2- (N- (2 , 4-dimethylphenyl) -N-methylamino) - 5-amino-pyridine 2- (N- (2 , 4-dimethyIphenyl) -N-methylamino) -5-amino- pyridine was prepared from l-amino-2 , 4-dimethylbenzene and 2-chloro-5-nitropyridine in the same manner as 2- (N- Cyclohexyl-N-methylamino) -5-amino-pyri ine was prepared. Example 12 Preparation of 2 , 6-Dichloro-N- (2- (N' -cyclohexyl-N' methylamino) -pyridin-5-yl) -benzamide 2- (N-Cyclohexyl-N-methylamino) -5-amino-pyridine (26 mg, 0.13 mmol) dissolved in methylene chloride (0.25 mL) was treated with triethylamine (0.026 mL, 0.18 mmol) followed by a solution of 2 , 6-dichlorobenzoyl chloride (31 mg, 0.15 mmol) dissolved in methylene chloride (0.15 mL) . The reaction mixture was shaken at 22°C for 18 hours followed by quenching with saturated aqueous NH 4 C1 and stirring for an additional 5 hours. The organic layer was separated and dried over Na 2 S0 4 then concentrated in vacuo . The crude product was purified by chromatography on Si0 2 using 1:1 ethyl acetate / hexane as eluent. MS (m/z) : 378/380 (M+H) + ; C 19 H 21 N 3 0C1 requires 377. Example 13 The compounds listed in Table 5 were prepared from substituted 5-aminopyridine compounds and the appropriate acid chloride in the same manner as 2,6- Dichloro-N- (2- (N' -cyclohexyl-N' -methylamino) -pyridin-5- yl) -benzamide was prepared. Table 5 MS (m/z) 2- (N-cyclohexyl-N-methylamino) -5- ( (2 , 6- 378 dichlorophenyl ) carbonylamino) pyridine 2- (N-cyclohexyl-N-methylamino) -5- ( (2- 344 chlorophenyl) carbonylamino)pyridine 2- (N-cyclohexyl-N-methylamino) -5- ( (2- 323 methylphenyl) carbonylamino)pyridine 2- (N-cyclohexyl-N-methylamino) -5- ((2,6- 337 dimethylphenyl) carbonylamino) pyridine 2-(2,4-dimethylphenyl)-5-( (2,6- 359 dimethylphenyl ) carbonylamino) pyridine 2- (2,4-dimethylphenyl)-5- ( (2- 345 methylphenyl ) carbonylamino) yridine 2- (2, 4-dimethylphenyl) -5- ( (2- 366 chlorophenyl ) carbonylamino)pyridine 2-(2,4-dimethylphenyl)-5-( (2- 349 fluorophenyl ) carbonylamino) pyridine 2- (2, 4-dimethylphenyl) -5- ( (2,6- 400 dichlorophenyl ) carbonylamino) pyridine Example 14 Preparation of 2- (4-Chloro-2-methyl-phenoxy) -5- (N- methylamino)pyridine 2- (4-Chloro-2-methyl-phenoxy) -5-aminopyridine (2.15 g, 9.16 mmol) was combined with powdered sodium hydroxide (1.46 g, 36.6 mmol), potassium carbonate (1.27 g, 9.16 mmol), tetrabutyl ammonium bromide (60 mg, 0.18 mmol) and toluene (10 L) was stirred for 1 hour at 35°C. A solution of dimethyl sulfate (0.91 L, 9.6 mmol) dissolved in toluene (5 mL) was added slowly. The mixture was heated at 35°C for 20 hours. After cooling, the solids were removed by filtration and the solvent was concentrated in vacuo . The desired material was purified by chromatography on Si0 2 using 30% ethyl acetate / hexanes as eluent. MS (m/z) : 248/250 (M+H) + ; C 13 H 13 N 2 0C1 requires 249. Preparation of 2 , 6-Dichloro-N- (6- (4-chloro-2-methyl- phenoxy) -pyridin-3-yl) -N-methyl-benzamide 2- (4-Chloro-2-methyl-phenoxy) -5- (N-methylamino)pyridine (32 mg, 0.13 mmol) dissolved in methylene chloride (0.25 mL) was treated with triethylamine (0.026 mL, 0.18 mmol) followed by a solution of 2 , 6-dichlorobenzoyl chloride (31 mg, 0.15 mmol) dissolved in methylene chloride (0.15 mL) . The reaction mixture was shaken at 22°C for 18 hours followed by quenching with saturated aqueous NH 4 C1 and stirring for an additional 5 hours. The organic layer was separated and dried over Na 2 S0 4 then concentrated in vacuo . The crude product was purified by chromatography on Si0 2 using 1:1 ethyl acetate / hexane as eluent. MS (m/z) : 422/424 (M+H) + ; C 20 H 15 N 2 O 2 Cl 3 requires 422. Example 16 Preparation of -C oro-N- (6- (4-chloro-2-methyl- phenoxy) -pyridin-3-yl) -N-methyl-benzamide 2-Chloro-N- (6- (4-chloro-2-methyl-phenoxy) -pyridin-3-yl) N-methyl-benzamide was prepared from 2- (4-Chloro-2- methyl-phenoxy) -5- (N-methylamino)pyridine and 2- chlorobenzoyl chloride in the same manner as 2,6- Dichloro-N- (6- (4-chloro-2-methyl-phenoxy) -pyridin-3-yl) N-methyl-benzamide was prepared. Preparation of 2-Methyl-N- (6- (4-chloro-2-methyl- phenoxy) -pyridin-3-yl) -N-methyl-benzamide 2-Methyl-N- (6- (4-chloro-2-methyl-phenoxy) -pyridin-3-yl) N-methyl-benzamide was prepared from 2- (4-Chloro-2- ethyl-phenoxy) -5- (N-methylamino)pyridine and 2- methylbenzoyl chloride in the same manner as 2,6- Dichloro-N- (6- (4-chloro-2-methyl-phenoxy) -pyridin-3-yl) N-methyl-benzamide was prepared. Example 18 General procedure for the synthesis of 2-substituted-5- acylamino-pyridines A solution of the 2-substituted-5-aminopyridine (10 mmol) , triethylamine (20 mmol) and an acid chloride (20 mmol) in ethanol free chloroform (250 mL) was shaken for 16 hours. The mixture was then diluted with saturated aqueous sodium hydrogencarbonate (50 mL) and dichloromethane (500 mL) , and shaken for 30 min. The mixture was then filtered through anhydrous magnesium sulfate, washing with dichloromethane (250 mL) . Concentration of the filtrate under reduced pressure afforded the desired 2-substituted-5-acylamino- pyridines . The compounds listed in Table 6 were prepared from substituted 5-aminopyridine compounds and the appropriate acid chloride according to the general procedure above . Table 6 R'X R J MS [m/z: 4-chloro-2- 4-biphenyl 415 methylphenoxy 4-chloro-2- 3 , 4-dimethoxyphenyl 319 methylphenoxy 4-chloro-2- 2- ( trifluoromethyl) phenyl 407 methylphenoxy 4-chloro-2- 2 , 4-difluorophenyl 375 methylphenoxy 4-chloro-2- 4-cyanopheny1 364 methylphenoxy 4-chloro-2- 3- (trifluoromethyl) phenyl 407 methylphenoxy 4-chloro-2- 3-cyanopheny1 364 methylphenoxy 4-chloro-2- 2-naphthyl 389 methylphenoxy 4-chloro-2- 2-methoxyphenyl 369 methylphenoxy 4-chloro-2- 3,4, 5-trimethylphenyl 429 methylphenoxy 4-chloro-2- 4-nitrophenyl 384 methylphenoxy 4-chloro-2- 3 , 4-dichlorophenyl 408 ethylphenoxy 4-chloro-2- 5-nitrofuran-2-yl 374 methylphenoxy 4-chloro-2- 3 -bromophenyl 418 ethylphenoxy 4-chloro-2- 3-pyridyl 340 methylphenoxy 4-chloro-2- 2-ethoxynaphth-l-yl 433 methylphenoxy 4-chloro-2- 2 , 3 -dichlorophenyl 408 ethylphenoxy 4-chloro-2- 3 -nitrophenyl 384 methylphenoxy 4-chloro-2- 6-chloropyrid-3-yl 374 methylphenoxy 4-chloro-2- 4- (trifluoromethoxy) phenyl 423 methylphenoxy 4-chloro-2- 2-fluoro-4- 425 methylphenoxy ( trifluoromethyl ) phenyl 4-chloro-2- 2-acetoxyphenyl 397 methylphenoxy 4-chloro-2- 5-methylisoxazol-3-yl 344 methylphenoxy 4-chloro-2- 2- (phenylthio) pyrid-3-yl 448 raethylphenoxy 4-chloro-2- 2- ( trifluoromethoxy) phenyl 423 methylphenoxy 4-chloro-2- 1-phenyl-5-propyl-pyrazin- 447 methylphenoxy 4-yl 4-chloro-2- 2-ethoxyphenyl 383 methylphenoxy 4-chloro-2- 3-chlorothien-2-yl 379 methylphenoxy 4-chloro-2- 3-bromothien-2-yl 424 methylphenoxy 4-chloro-2- l-(2-(2-methyl)propyl)-3- 399 methylphenoxy methylpyrazol-5-yl 4-chloro-2- 3 , 5-dichlorophenyl 408 methylphenoxy 4-chloro-2- 2- (propylthio) pyridin-3-yl 414 methylphenoxy 4-chloro-2- 2-(ethylthio)pyridin-3-yl 400 methylphenoxy 4-chloro-2- 3-bromopyridin-5-yl 419 methylphenoxy 4-chloro-2- 4-methyl-l,2,3-thiadiazol- 361 methylphenoxy 5-yl 4-chloro-2- l-methyl-3-(2-(2- 399 methylphenoxy methyl ) ropyl) yrazol-5-yl 4-chloro-2- 3-chlorobenzo[b] thiophen- 429 methylphenoxy 2-yl 4-chloro-2- 4-chlorophenyl 373 methylphenoxy 4-chloro-2- 4-methyl-2-phenyl-l,2,3- 420 methylphenoxy triazol-5-yl 4-chloro-2- benzo [b] thiophen-2-yl 395 methylphenoxy 4-chloro-2- 3 , 4-dimethylphenyl 367 methylphenoxy 4-chloro-2- 2- (phenoxy) pyridin-3-yl 432 methylphenoxy 4-chloro-2- 2- (methylthio)pyridin-3-yl 386 methylphenoxy 4-chloro-2- 5-methyl-3-phenylisoxazol- 420 methylphenoxy 4-yl 4-chloro-2- 4-chloro-l,3-dimethyl 442 methylphenoxy pyrazolo [3 , 4-b]pyridin-3- yi 4-chloro-2- 2-chloro-6-methylpyridin- 388 methylphenoxy 4-yl 4-chloro-2- 3 , 5-dimethylisoxazol-4-yl 358 methylphenoxy 4-chloro-2- 1-naphthyl 389 methylphenoxy 4-chloro-2- 2-fluorophenyl 357 methylphenoxy 4-chloro-2- 4-propyIphenyl 381 methylphenoxy 4-chloro-2- 4- (trifluoromethyl) phenyl 407 methylphenoxy 4-chloro-2- 3 -fluorophenyl 357 ethylphenoxy 4-chloro-2- 2 , 6-difluorophenyl 375 methylphenoxy 4-chloro-2- 2-chlorophenyl 373 methylphenoxy 4-chloro-2- 3- (chloromethyl ) phenyl 387 methylphenoxy 4-chloro-2- 4-(2-(2-methyl) 395 methylphenoxy propyl ) phenyl 4-chloro-2- 3 -chlorophenyl 373 methylphenoxy 4-chloro-2- 2-nitrophenyl 384 methylphenoxy 4-chloro-2- 3 , 5-dimethoxyphenyl 399 methylphenoxy 4-chloro-2- 2 , 6-dichlorophenyl 408 methylphenoxy 4-chloro-2- 2 , 4-dichlorophenyl 408 methylphenoxy 4-chloro-2- 4-fluorophenyl 357 methylphenoxy 4-chloro-2- 4-butylpheny1 395 methylphenoxy 4-chloro-2- 2-methylphenyl 353 ethylphenoxy 4-chloro-2- phenyl 339 methylphenoxy 4-chloro-2- 4-ethyIphenyl 367 methylphenoxy 4-chloro-2- 2 , 3 -difluorophenyl 375 methylphenoxy 4-chloro-2- 2 , 6-dimethoxyphenyl 399 methylphenoxy 4-chloro-2- 2 , 5-difluorophenyl 375 methylphenoxy 4-chloro-2- 4-ethoxypheny1 383 methylphenoxy 4-chloro-2- 2,4, 6-trichlorophenyl 442 methylphenoxy 4-chloro-2- 3-methylphenyl 353 methylphenoxy 4-chloro-2- 2-fluoro-5- 425 methylphenoxy ( trifluoromethyl ) phenyl 4-chloro-2- 3 -methoxyphenyl 369 methy1phenoxy 4-chloro-2- thien-2-yl 345 methylphenoxy 4-chloro-2- 2-bromophenyl 418 methylphenoxy 4-chloro-2- 4-bromophenyl 418 methylphenoxy 4-chloro-2- 4-fluoro-3- 425 ethylphenoxy ( trifluoromethyl ) phenyl 4-chloro-2- 3- (trifluoromethoxy) phenyl 423 methylphenoxy 4-chloro-2- 9-fluorenon-4-yl 441 methylphenoxy 4-chloro-2- isoxazol-5-yl 330 methylphenoxy 4-chloro-2- benzofuroxan-5-y1 397 methylphenoxy 4-chloro-2- 2-chloropyrid-3-yl 374 methylphenoxy 4-chloro-2- 3 , 5-difluorophenyl 375 methylphenoxy 4-chloro-2- 2-(4- 446 methylphenoxy methylphenoxy) pyridin-3-yl 4-chloro-2- pyridin-4-yl 340 methylphenoxy 4-chloro-2- anthraquinon-2-yl 469 methylphenoxy 4-chloro-2- 2-iodophenyl 465 methylphenoxy 1-naphthoxy 4-biphenyl 416 1-naphthoxy 3 , 4-dimethoxyphenyl 400 1-naphthoxy 2- (trifluoromethyl) phenyl 408 1-naphthoxy 2, 4-difluorophenyl 376 1-naphthoxy 4-cyanopheny1 365 -naphthoxy 3- (trifluoromethyl) phenyl 408 -naphthoxy 3 -cyanopheny1 365 -naphthoxy 2-naphthyl 390 -naphthoxy 2-methoxyphenyl 370 -naphthoxy 3,4, 5-trimethylphenyl 430 -naphthoxy 4-nitrophenyl 385 -naphthoxy 3 , 4-dichlorophenyl 409 -naphthoxy 5-nitrofuran-2-yl 375 -naphthoxy 3-bromophenyl 419 -naphthoxy 3-pyridyl 341 -naphthoxy 2-ethoxynaphth-l-yl 334 -naphthoxy 2 , 3-dichlorophenyl 409 -naphthoxy 3-nitrophenyl 385 -naphthoxy 6-chloropyrid-3-yl 376 -naphthoxy 4- (trifluoromethoxy) phenyl 424 -naphthoxy 2-fluoro-4- 426 ( trifluoromethyl ) phenyl -naphthoxy 3-bromothiophenyl 425 -naphthoxy 2-acetoxyphenyl 398 -naphthoxy 5-methylisoxazol-3-yl 345 -naphthoxy 2- (phenylthio)pyrid-3 -yl 449 -naphthoxy 2- (trifluoromethoxy) phenyl 424 -naphthoxy 1-phenyl-5-propylpyrazin- 448 4-yl -naphthoxy 2-ethoxyphenyl 384 -naphthoxy 3-chlorothien-2-yl 381 -naphthoxy l-(2- (2-methyl ) propyl) -3- 400 methylpyrazol-5-yl -naphthoxy 3 , 5-dichlorophenyl 409 -naphthoxy 2- (propylthio) pyridin-3-yl 415 -naphthoxy 2- (ethylthio)pyridin-3-yl 401 -naphthoxy 3 -bromopyridin-5-yl 420 -naphthoxy 4-methyl-1 , 2 , 3-thiadiazol- 362 5-yl -naphthoxy l-methyl-3- (2- (2- 400 methyl ) propyl ) pyrazol-5-yl -naphthoxy 3-chlorobenzo [b] thiophen- 431 2-yl -naphthoxy 4-chlorophenyl 375 -naphthoxy 4-methyl-2-phenyl-1, 2 , 3- 421 triazol-5-yl -naphthoxy benzo [b] thiophen-2-yl 396 -naphthoxy 3 , 4-dimethylphenyl 368 -naphthoxy 2- (phenoxy) pyridin-3-yl 433 -naphthoxy 2- (methylthio) pyridin-3-yl 387 -naphthoxy 5-methyl-3-phenylisoxazol- 421 4-yl -naphthoxy 4-chloro-l,3-dimethyl 444 pyrazolo [3 , 4-b]pyridin-3- yi -naphthoxy 2-chloro-6-methylpyridin- 390 4-yl -naphthoxy 3 , 5-dimethylisoxazol-4-yl 359 -naphthoxy 1-naphthyl 390 -naphthoxy 2 -fluorophenyl 358 -naphthoxy 4-propyIphenyl 382 -naphthoxy 4- ( trifluoromethyl ) phenyl 408 -naphthoxy 3 -fluorophenyl 358 -naphthoxy 2 , 6-difluorophenyl 376 -naphthoxy 2 -chlorophenyl 375 -naphthoxy 3 - ( chloromethyl ) phenyl 389 -naphthoxy 4-(2-(2- 396 methyl ) propyl ) phenyl -naphthoxy 3 -chlorophenyl 375 -naphthoxy 2 -nitrophenyl 385 -naphthoxy 3 , 5-dimethoxyphenyl 400 -naphthoxy 2 , 6-dichlorophenyl 409 -naphthoxy 2 , 4-dichlorophenyl 409 -naphthoxy 4- fluorophenyl 358 -naphthoxy 4-butylphenyl 396 -naphthoxy 2 -methylphenyl 354 -naphthoxy phenyl 340 -naphthoxy 4-ethylphenyl 368 -naphthoxy 2 , 3-difluorophenyl 376 -naphthoxy 2 , 6-dimethoxyphenyl 400 -naphthoxy 3 , 4-difluorophenyl 376 -naphthoxy 2 , 5-difluorophenyl 376 -naphthoxy 4-ethoxyphenyl 384 -naphthoxy 2,4, 6-trichlorophenyl 444 -naphthoxy 3 -methylphenyl 354 -naphthoxy 2-fluoro-5- 426 ( trifluoromethyl ) phenyl -naphthoxy 3 -methoxyphenyl 370 -naphthoxy thien-2-yl 346 -naphthoxy 2 -bromophenyl 419 -naphthoxy 4-bromophenyl 419 -naphthoxy 4-fluoro-3- 426 ( trifluoromethyl ) phenyl -naphthoxy 3- (trifluoromethoxy) phenyl 424 -naphthoxy 9-fluorenon-4-yl 442 -naphthoxy isoxazol-5-yl 331 -naphthoxy benzofuroxan-5-y1 398 -naphthoxy 2-chloropyrid-3-yl 376 -naphthoxy 3 , 5-difluorophenyl 376 -naphthoxy 2-(4- 447 ethylphenoxy) pyridin-3 -yl -naphthoxy pyridin-4-yl 341 -naphthoxy anthraquinon-2-yl 470 -naphthoxy 2-iodophenyl 466 - ( 2-propyl ) phenoxy 4-biphenyl 408 - ( 2-propyl ) phenoxy 3 , 4-dimethoxyphenyl 392 - (2-propyl )phenoxy 2- (trifluoromethyl) phenyl 400 - ( 2-propyl ) phenoxy 2 , 4-difluorophenyl 368 - (2-propyl )phenoxy 4-cyanopheny1 357 - ( 2-propyl ) phenoxy 3- (trifluoromethyl) phenyl 400 - (2-propyl ) phenoxy 3-cyanopheny1 357 - (2-propyl ) phenoxy 2-naphthyl 382 - ( 2-propyl ) phenoxy 2-methoxyphenyl 362 - ( 2-propyl ) phenoxy 3,4,5, -trimethylphenyl 422 - ( 2-propyl ) phenoxy 4-nitrophenyl 377 - ( 2-propyl ) phenoxy 3 , 4-dichlorophenyl 401 - (2-propyl ) phenoxy 5-nitrofuran-2-yl 367 - (2-propyl )phenoxy 3 -bromophenyl 411 - ( 2-propyl ) phenoxy 3 -pyridyl 333 - 2-propyl ) phenoxy 2-ethoxynaphth-l-yl 426 - 2-propyl ) phenoxy 2 , 3-dichlorophenyl 401 - 2 -propyl ) phenoxy 3-nitrophenyl 377 - 2 -propyl ) phenoxy 6-chloropyrid-3-yl 368 - 2 -propyl ) phenoxy 4- (trifluoromethoxy) phenyl 416 - 2-propyl ) phenoxy 2-fluoro-4- 418 ( trifluoromethyl ) phenyl - 2 -propyl ) phenoxy 3-bromothiophenyl 417 - 2-propyl ) phenoxy 2-acetoxyphenyl 390 - 2-propyl ) phenoxy 5-methylisoxazol-3-yl 337 - 2-propyl ) phenoxy 2- (phenylthio)pyrid-3-yl 442 - 2-propyl) phenoxy 2- (trifluoromethoxy) phenyl 416 - 2-propyl ) phenoxy l-phenyl-5-propylpyrazin- 441 4-yl - 2-propyl ) phenoxy 2-ethoxyphenyl 376 - 2-propyl )phenoxy 3-chlorothien-2-yl 373 - 2-propyl ) phenoxy l-(2-(2-methyl)proρyl)-3- 392 methylpyrazol-5-yl - 2-propyl ) phenoxy 3 , 5-dichlorophenyl 401 - 2-propyl)phenoxy 2- (propylthio) pyridin-3-yl 407 - 2-propyl ) phenoxy 2-(ethylthio)pyridin-3-yl 393 - 2-propyl ) phenoxy 3-bromopyridin-5-yl 412 - 2-propyl ) phenoxy 4-methyl-l,2,3-thiadiazol- 354 5-yl - 2-propyl ) phenoxy l-methyl-3-(2-(2- 392 methyl) propyl )pyrazol-5-yl - 2-propyl ) phenoxy 3-chlorobenzo[b] thiophen- 423 2-yl 2-propyl ) phenoxy 4-chlorophenyl 367 - ( 2-propyl ) phenoxy 4-methyl-2-phenyl-l,2,3- 413 triazol-5-yl - 2-propyl ) phenoxy benzo [b] thiophen-2-yl 388 - 2-propyl ) phenoxy 3 , 4-dimethylphenyl 360 - 2-propyl ) phenoxy 2- (phenoxy) pyridin-3-yl 425 - 2-propyl ) phenoxy 2- (methylthio) pyridin-3-yl 379 - 2-propyl ) phenoxy 5-methyl-3-phenylisoxazol- 413 4-yl 2-propyl ) phenoxy 4-chloro-l,3- 436 dimethylpyrazolo [3,4- b]pyridin-3-yl 2-propyl ) phenoxy 2-chloro-6-methylpyridin- 382 4-yl - (2-propyl)phenoxy 3 , 5-dimethylisoxazol-4- -yi 351 - (2-propyl )phenoxy 1-naphthyl 382 - (2-propyl )phenoxy 2-fluorophenyl 350 - (2-propyl)phenoxy 4-propyIphenyl 374 - (2-propyl )phenoxy 4- (trifluoromethyl) phenyl 400 - (2-propyl)phenoxy 3-fluorophenyl 350 - (2-propyl )phenoxy 2 , 6-difluorophenyl 368 - (2-propyl)phenoxy 2-chlorophenyl 367 - (2-propyl)phenoxy 3- (chloromethyl ) phenyl 381 - (2-propyl)phenoxy 4-(2-(2- 388 methyl) propyl) phenyl - (2-propyl)phenoxy 3-chlorophenyl 367 - (2-propyl) phenoxy 2-nitropheny1 377 - (2-propyl)phenoxy 3 , 5-dimethoxyphenyl 392 - (2-propyl)phenoxy 2 , 6-dichlorophenyl 401 - (2-propyl)phenoxy 2 , 4-dichlorophenyl 401 -(2-propyl) henoxy 4-fluoropher -( 2-propyl) henoxy 4-butyIphenyl -( 2-propyl ) phenoxy 2 -methylphenyl -( 2-propyl ) phenoxy phenyl -( 2-propyl) phenoxy 4-ethyIphenyl -( 2-propyl)phenoxy 2 , 3 -difluorophenyl -( 2-propyl)phenoxy 2 , 6-dimethoxyphenyl 392 -( 2-propyl)phenoxy 3 , 4-difluorophenyl 368 -( 2-propyl)phenoxy 2 , 5-difluorophenyl 368 -( 2-propyl)phenoxy 4-ethoxyphenyl 376 -( 2-propyl)phenoxy 2,4, 6-trichlorophenyl 436 -( 2-propyl)phenoxy 3 -methylphenyl 346 -( 2-propyl)phenoxy 2-fluoro-5- 418 ( trifluoromethyl ) phenyl - 2-propyl)phenoxy 3 -methoxyphenyl 362 - 2-propyl)phenoxy thien-2-yl 338 - 2-propyl)phenoxy 2-bromophenyl 411 - 2-propyl)phenoxy 4-bromophenyl 411 - 2-propyl)phenoxy 4-fluoro-3- 418 ( trifluoromethyl ) phenyl - 2-propyl) henoxy 3- (trifluoromethoxy) phenyl 416 - k2-propyl) henoxy 9-fluorenon-4-yl 434 - (2-propyl)phenoxy isoxazol-5-yl 323 - (2-propyl)phenoxy benzofuroxan-5-yl 390 - (2-propyl)phenoxy 2-chloropyrid-3-yl 368 - (2-propyl)phenoxy 3 , 5-difluorophenyl 368 - (2-propyl) phenoxy 2-(4- 439 methylphenoxy) pyridin-3 -yl 2- (2-propyl ) phenoxy pyridin-4-yl 333 2- ( 2-propyl ) phenoxy anthraquinon-2-yl 462 2- (2-propyl ) phenoxy 2-iodophenyl 458 3-fluoro-5- 4-biphenyl 398 methylphenoxy 3-fluoro-5- 3 , 4-dimethoxyphenyl 382 methylphenoxy 3-fluoro-5- 2- (trifluoromethyl) phenyl 390 methylphenoxy 3-fluoro-5- 2, 4-difluorophenyl 358 methylphenoxy 3-fluoro-5- 4-cyanopheny1 347 methylphenoxy 3-fluoro-5- 3- (trifluoromethyl) phenyl 390 ethylphenoxy 3-fluoro-5- 3-cyanopheny1 347 ethylphenoxy 3-fluoro-5- 2-naphthyl 372 methy1phenoxy 3-fluoro-5- 2-methoxyphenyl 352 methylphenoxy 3-fluoro-5- 3,4,5, -trimethylphenyl 412 ethylphenoxy 3-fluoro-5- 4-nitrophenyl 367 methylphenoxy 3-fluoro-5- 3 , 4-dichlorophenyl 391 methylphenoxy 3-fluoro-5- 5-nitrofuran-2-yl 357 methylphenoxy 3-fluoro-5- 3 -bromophenyl 401 methylphenoxy 3-fluoro-5- 3 -pyridyl 323 ethylphenoxy 3-fluoro-5- 2 -ethoxynaphth-1-yl 416 methylphenoxy 3-fluoro-5- 2 , 3 -dichlorophenyl 391 methylphenoxy 3-fluoro-5- 3 -nitrophenyl 367 methylphenoxy 3-fluoro-5- 6-chloropyrid-3-yl 358 methylphenoxy 3-fluoro-5- 4- (trifluoromethoxy) phenyl 406 methylphenoxy 3-fluoro-5- 2-fluoro-4- 408 methylphenoxy ( trifluoromethyl ) phenyl 3-fluoro-5- 3 -bromothienyl 407 methylphenoxy 3-fluoro-5- 2-acetoxyphenyl 380 methylphenoxy 3-fluoro-5- 5-methylisoxazol-3-yl 327 methylphenoxy 3-fluoro-5- 2- (phenylthio) pyrid-3-yl 431 methylphenoxy 3-fluoro-5- 2- ( trifluoromethoxy) phenyl 406 methylphenoxy 3-fluoro-5- 1-phenyl-5-propylpyrazin- 430 methylphenoxy 4-yl 3-fluoro-5- 2-ethoxyphenyl 366 methylphenoxy 3-fluoro-5- 3-chlorothien-2-yl 363 methylphenoxy 3-fluoro-5- l-(2-(2-methyl)propyl)-3- 382 methylphenoxy methylpyrazol-5-yl 3-fluoro-5- 3 , 5-dichlorophenyl 391 methylphenoxy 3-fluoro-5- 2- (propylthio)pyridin-3-yl 397 methylphenoxy 3-fluoro-5- 2-(ethylthio)pyridin-3-yl 383 methylphenoxy 3-fluoro-5- 3-bromopyridin-5-yl 402 methylphenoxy 3-fluoro-5- 4-methyl-l,2,3-thiadiazol- 344 methylphenoxy 5-yl 3-fluoro-5- l-methyl-3-(2-(2- 382 methylphenoxy methyl ) propyl ) pyrazol-5-yl 3-fluoro-5- 3-chlorobenzo [b] thiophen- 413 methylphenoxy 2-yl 3-fluoro-5- 4-chlorophenyl 357 methylphenoxy 3-fluoro-5- 4-methyl-2-phenyl-l,2,3- 403 methylphenoxy triazol-5-yl 3-fluoro-5- benzo [b] thiophen-2-yl 378 methylphenoxy 3-fluoro-5- 3 , 4-dimethylphenyl 350 methylphenoxy 3-fluoro-5- 2- (phenoxy) pyridin-3-yl 415 methylphenoxy 3-fluoro-5- 2- (methylthio)pyridin-3-yl 369 methylphenoxy 3-fluoro-5- 5-methyl-3-phenylisoxazol- 403 methylphenoxy 4-yl 3-fluoro-5- 4-chloro-1,3 -dimethyl 426 methylphenoxy pyrazolo[3, 4-b]pyridin-3- yi 3-fluoro-5- 2-chloro-6-methylpyridin- 372 methylphenoxy 4-yl 3-fluoro-5- 3 , 5-dimethylisoxazol-4-yl 341 methylphenoxy 3-fluoro-5- 1-naphthyl 372 methylphenoxy 3-fluoro-5- 2 -fluorophenyl 340 methylphenoxy 3-fluoro-5- 4-propylphenyl 364 methylphenoxy 3-fluoro-5- 4- (trifluoromethyl) phenyl 390 ethylphenoxy 3-fluoro-5- 3-fluorophenyl 340 methylphenoxy 3-fluoro-5- 2 , 6-difluorophenyl 358 methylphenoxy 3-fluoro-5- 2-chlorophenyl 357 methylphenoxy 3-fluoro-5- 3- ( chloromethyl ) phenyl 371 methylphenoxy 3-fluoro-5- 4-(2-(2- 378 methylphenoxy methyl ) propyl ) phenyl 3-fluoro-5- 3-chlorophenyl 357 methylphenoxy 3-fluoro-5- 2-nitrophenyl 367 methylphenoxy 3-fluoro-5- 3 , 5-dimethoxyphenyl 382 methylphenoxy 3-fluoro-5- 2 , 6-dichlorophenyl 391 methylphenoxy 3-fluoro-5- 2 , 4-dichlorophenyl 391 methylphenoxy 3-fluoro-5- 4-fluorophenyl 340 methylphenoxy 3-fluoro-5- 4-butyIphenyl 378 methylphenoxy 3-fluoro-5- 2-methylphenyl 336 methylphenoxy 3-fluoro-5- phenyl 322 methylphenoxy 3-fluoro-5- 4-ethylphenyl 350 methylphenoxy 3-fluoro-5- 2 , 3 -difluorophenyl 358 methylphenoxy 3-fluoro-5- 2 , 6-dimethoxyphenyl 382 methylphenoxy 3-fluoro-5- 3 , 4-difluorophenyl 358 methylphenoxy 3-fluoro-5- 2 , 5-difluorophenyl 358 methylphenoxy 3-fluoro-5- 4-ethoxyphenyl 366 methylphenoxy 3-fluoro-5- 2,4, 6-trichlorophenyl 426 methylphenoxy 3-fluoro-5- 3-methylphenyl 336 methylphenoxy 3-fluoro-5- 2-fluoro-5- 408 methylphenoxy ( trifluoromethyl ) phenyl 3-fluoro-5- 3 -methoxyphenyl 352 methylphenoxy 3-fluoro-5- thien-2-yl 328 ethylphenoxy 3-fluoro-5- 2 -bromophenyl 401 methylphenoxy 3-fluoro-5- 4-bromophenyl 401 methylphenoxy 3-fluoro-5- 4-fluoro-3- 408 methylphenoxy ( trifluoromethyl ) henyl 3-fluoro-5- 3- (trifluoromethoxy) phenyl 406 methylphenoxy 3-fluoro-5- 9-fluorenon-4-yl 424 methylphenoxy 3-fluoro-5- isoxazol-5-yl 313 methylphenoxy 3-fluoro-5- benzofuroxan-5-yl 380 ethylphenoxy 3-fluoro-5- 2-chloropyrid-3-yl 358 ethylphenoxy 3-fluoro-5- 3 , 5-difluorophenyl 358 ethylphenoxy 3-fluoro-5- 2-(4- 429 ethylphenoxy methylphenoxy)pyridin-3-yl 3-fluoro-5- pyridin-4-yl 323 methylphenoxy 3-fluoro-5- anthraquinon-2-yl 452 methylphenoxy 3-fluoro-5- 2-iodophenyl 448 methylphenoxy 2-methylpyrid-3-yloxy 4-biphenyl 381 2-methylpyrid-3-yloxy 3 , 4-dimethoxyphenyl 365 -methylpyrid-3-yloxy 2- (trifluoromethyl) phenyl 373 -methylpyrid-3-yloxy 2 , 4-difluorophenyl 341 -methylpyrid-3-yloxy 4-cyanopheny1 330 -methylpyrid-3 -yloxy 3- (trifluoromethyl) phenyl 373 -methylpyrid-3-yloxy 3 -cyanopheny1 330 -methylpyrid-3-yloxy 2-naphthyl 355 -methylpyrid-3-yloxy 2-methoxyphenyl 335 -methylpyrid-3-yloxy 3 , 4, 5-trimethyIphenyl 395 -methylpyrid-3-yloxy 4-nitrophenyl 350 -methylpyrid-3-yloxy 3 , 4-dichlorophenyl 374 -methylpyrid-3-yloxy 5-nitrofuran-2-yl 340 -methylpyrid-3-yloxy 3-bromophenyl 384 -methylpyrid-3-yloxy 3-pyridyl 306 -methylpyrid-3-yloxy 2-ethoxynaphth-l-yl 399 -methylpyrid-3-yloxy 2 , 3-dichlorophenyl 374 -methylpyrid-3-yloxy 3-nitrophenyl 350 -methylpyrid-3-yloxy 6-chloropyrid-3-yl 341 -methylpyrid-3-yloxy 4- (trifluoromethoxy) phenyl 389 -methylpyrid-3-yloxy 2-fluoro-4- 391 ( trifluoromethyl)phenyl -methylpyrid-3-yloxy 3-bromothienyl 390 -methylpyrid-3-yloxy 2-acetoxyphenyl 363 -methylpyrid-3-yloxy 5-methylisoxazol-3-yl 310 -methylpyrid-3-yloxy 2- (phenylthio) pyrid-3-yl 414 -methylpyrid-3-yloxy 2- (trifluoromethoxy) phenyl 389 -methylpyrid-3-yloxy l-phenyl-5-propylpyrazin- 413 4-yl -methylpyrid-3-yloxy 2-ethoxyphenyl 349 -methylpyrid-3-yloxy 3-chlorothien-2-yl 346 -methylpyrid-3-yloxy 1- (2- (2 -methyl) propyl) -3- 365 methylpyrazol-5-yl -methylpyrid-3 -yloxy 3 , 5-dichlorophenyl 374 -methylpyrid-3-yloxy 2- (propylthio) pyridin-3-yl 380 -methylpyrid-3-yloxy 2- (ethylthio) pyridin-3-yl 366 -methylpyrid-3-yloxy 3-bromopyridin-5-yl 385 -methylpyrid-3-yloxy 4-methyl-l, 2, 3-thiadiazol- 327 5-yl -methylpyrid-3-yloxy 1-methyl-3- (2- (2- 365 methyl ) propyl ) pyrazol- 5-yl -methylpyrid-3-yloxy 3-chlorobenzo [b] thiophen- 396 2-yl -methylpyrid-3-yloxy 4-chlorophenyl 340 -methylpyrid-3-yloxy 4-methyl-2-phenyl-1, 2 , 3- 386 triazol-5-yl -methylpyrid-3-yloxy benzo [b] thiophen-2-yl 361 -methylpyrid-3-yloxy 3 , 4-dimethyIphenyl 333 -methylpyrid-3-yloxy 2- (phenoxy) pyridin-3-yl 398 -methylpyrid-3-yloxy 2- (methylthio)pyridin-3-yl 352 -methylpyrid-3-yloxy 5-methyl-3-phenylisoxazol- 386 4-yl -methylpyrid-3-yloxy 4-chloro-l, 3-dimethyl 409 pyrazolo [3 , 4-b] pyridin-3- yi -methylpyrid-3-yloxy 2-chloro-6-methylpyridin- 355 4-yl -methylpyrid-3-yloxy 3 , 5-dimethylisoxazol-4-yl 324 -methylpyrid-3-yloxy 1-naphthyl 355 -methylpyrid-3-yloxy 2 -fluorophenyl 323 -methylpyrid-3 -yloxy 4-propylphenyl 347 -methylpyrid-3-yloxy 4- (trifluoromethyl) phenyl 373 -methylpyrid-3-yloxy 3-fluorophenyl 323 -methylpyrid-3-yloxy 2 , 6-difluorophenyl 341 -methylpyrid-3 -yloxy 2 -chlorophenyl 340 -methylpyrid-3-yloxy 3- (chloromethyl) phenyl 354 -methylpyrid-3-yloxy 4- (2- (2- 361 methyl ) propyl ) henyl -methylpyrid-3-yloxy 3 -chlorophenyl 340 -methylpyrid-3-yloxy 2-nitrophenyl 350 -methylpyrid-3-yloxy 3 , 5-dimethoxyphenyl 365 -methylpyrid-3-yloxy 2 , 6-dichlorophenyl 374 -methylpyrid-3-yloxy 2 , 4-dichlorophenyl 374 -methylpyrid-3-yloxy 4-fluorophenyl 323 -methylpyrid-3-yloxy 4-butylphenyl 361 -methylpyrid-3-yloxy 2 -methylphenyl 319 -methylpyrid-3-yloxy phenyl 305 -methylpyrid-3-yloxy 4-ethyIphenyl 333 -methylpyrid-3-yloxy 2 , 3-difluorophenyl 341 -methylpyrid-3-yloxy 2 , 6-dimethoxyphenyl 365 -methylpyrid-3-yloxy 3 , 4-difluorophenyl 341 -methylpyrid-3-yloxy 2 , 5-difluorophenyl 341 -methylpyrid-3 -yloxy 4-ethoxyphenyl 349 -methylpyrid-3-yloxy 2 , 4, 6-trichlorophenyl 409 -methylpyrid-3-yloxy 3 -methylphenyl 319 -methylpyrid-3-yloxy 2-fluoro-5- 391 ( trifluoromethyl ) phenyl -methylpyrid-3-yloxy 3 -methoxyphenyl 335 2-methylpyrid-3-yloxy thien-2-yl 311 2-methylpyrid-3-yloxy 2 -bromophenyl 384 2-methylpyrid-3-yloxy 4-bromophenyl 384 2-methylpyrid-3-yloxy 4-fluoro-3- 391 ( trifluoromethyl ) phenyl 2-methylpyrid-3-yloxy 3- (trifluoromethoxy) phenyl 389 2 -methylpyrid-3 -yloxy 9-fluorenon-4-yl 407 2-methylpyrid-3-yloxy isoxazol-5-yl 296 2-methylpyrid-3-yloxy benzofuroxan-5-yl 363 2-methylpyrid-3-yloxy 2-chloropyrid-3-yl 341 2-methylpyrid-3-yloxy 3 , 5-difluorophenyl 341 2-methylpyrid-3-yloxy 2- (4- 412 methylphenoxy) pyridin-3-yl 2-methylpyrid-3-yloxy pyridin-4-yl 306 2-methylpyrid-3-yloxy anthraquinon-2-yl 435 2-methylpyrid-3-yloxy 2-iodophenyl 431 4-chloro-2, 5- 3 , 4-dimethoxyphenyl 413 dimethylphenoxy 4-chloro-2, 5- 2- (trifluoromethyl) phenyl 421 dimethylphenoxy 4-chloro-2, 5- 2 , 4-difluorophenyl 389 dimethylphenoxy 4-chloro-2, 5- 3- ( trifluoromethyl ) phenyl 421 dimethylphenoxy 4-chloro-2,5- 2-naphthyl 403 dimethylphenoxy 4-chloro-2 , 5- 2-methoxyphenyl 484 dimethylphenoxy 4-chloro-2, 5- 3 , 4 , 5-trimethyIphenyl 443 dimethylphenoxy 4-chloro-2, 5- 3 , 4-dichlorophenyl 422 dimethylphenoxy 4-chloro-2, 5- 3-bromophenyl 432 dimethylphenoxy 4-chloro-2, 5- 3-pyridyl 354 di ethylphenoxy 4-chloro-2, 5- 2-ethoxynaphth-l-yl 447 dimethylphenoxy 4-chloro-2, 5- 2 , 3-dichlorophenyl 422 dimethylphenoxy 4-chloro-2, 5- 6-chloropyrid-3-yl 388 dimethylphenoxy 4-chloro-2, 5- 4- (trifluoromethoxy) phenyl 437 dimethylphenoxy 4-chloro-2, 5- 2-fluoro-4- 439 dimethylphenoxy ( trifluoromethyl ) phenyl 4-chloro-2, 5- 3 -bromothienyl 438 dimethylphenoxy 4-chloro-2,5- 2-acetoxyphenyl 411 di ethylphenoxy 4-chloro-2, 5- 5-methylisoxazol-3-yl 358 dimethylphenoxy 4-chloro-2, 5- 2- (phenylthio)pyrid-3 -yl 462 dimethylphenoxy 4-chloro-2, 5- 2- ( trifluoromethoxy) phenyl 437 dimethylphenoxy 4-chloro-2, 5- l-phenyl-5-propylpyrazin- 461 di ethylphenoxy 4-yl 4-chloro-2, 5- 2-ethoxyphenyl 397 dimethylphenoxy 4-chloro-2, 5- 3-chlorothien-2-yl 393 dimethylphenoxy 4-chloro-2 , 5- l-(2-(2-methyl)propyl)-3- 413 dimethylphenoxy methylpyrazol-5-yl 4-chloro-2 , 5- 3 , 5-dichlorophenyl 422 dimethylphenoxy 4-chloro-2, 5- 2- (propylthio)pyridin-3-yl 428 dimethylphenoxy 4-chloro-2 , 5- 2- (ethylthio)pyridin-3-yl 414 dimethylphenoxy 4-chloro-2 , 5- 3-bromopyridin-5-yl 433 dimethylphenoxy 4-chloro-2 , 5- 4-methyl-l, 2, 3-thiadiazol- 375 dimethylphenoxy 5-yl 4-chloro-2 , 5- l-methyl-3-(2-(2- 413 di ethylphenoxy methyl ) propyl ) pyrazol-5-yl 4-chloro-2, 5- 3-chlorobenzo [b] thiophen- 443 dimethylphenoxy 2-yl 4-chloro-2 , 5- 4-chlorophenyl 387 dimethylphenoxy 4-chloro-2 , 5- 4-methyl-2-phenyl-l,2,3- 434 dimethylphenoxy triazol-5-yl 4-chloro-2 , 5- benzo [b] thiophen-2-yl 409 dimethylphenoxy 4-chloro-2, 5- 3, 4-dimethyIphenyl 381 dimethylphenoxy 4-chloro-2, 5- 2- (phenoxy) pyridin-3-yl 446 dimethylphenoxy 4-chloro-2 , 5- 2-(methylthio)pyridin-3-yl 400 dimethylphenoxy 4-chloro-2 , 5- 5-methyl-3-phenylisoxazol- 434 dimethylphenoxy 4-yl 4-chloro-2, 5- 4-chloro-l, 3-dimethyl 456 dimethylphenoxy pyrazolo [3 , 4-b]pyridin-3- yi 4-chloro-2, 5- 2-chloro-6-methylpyridin- 402 dimethylphenoxy 4-yl 4-chloro-2 , 5- 3 , 5-dimethylisoxazol-4-yl 372 dimethylphenoxy 4-chloro-2, 5- 1-naphthyl 403 dimethylphenoxy 4-chloro-2 , 5- 2-fluorophenyl 371 dimethylphenoxy 4-chloro-2, 5- 4-propyIphenyl 395 dimethylphenoxy 4-chloro-2, 5- 3-fluorophenyl 371 dimethylphenoxy 4-chloro-2, 5- 2, 6-difluorophenyl 389 dimethylphenoxy 4-chloro-2 , 5- 2-chlorophenyl 387 dimethylphenoxy 4-chloro-2, 5- 3- (chloromethyl) phenyl 401 dimethylphenoxy 4-chloro-2, 5- 4-(2-(2- 409 dimethylphenoxy methyl ) propyl ) phenyl 4-chloro-2, 5- 3 -chlorophenyl 387 dimethylphenoxy 4-chloro-2, 5- 3 , 5-dimethoxyphenyl 413 dimethylphenoxy 4-chloro-2, 5- 2 , 6-dichlorophenyl 422 dimethylphenoxy 4-chloro-2, 5- 2, 4-dichlorophenyl 422 dimethylphenoxy 4-chloro-2, 5- 4-fluorophenyl 371 dimethylphenoxy 4-chloro-2, 5- 4-butylphenyl 409 di ethylphenoxy 4-chloro-2 , 5- 2-methylphenyl 367 dimethylphenoxy 4-chloro-2, 5- phenyl 353 dimethylphenoxy 4-chloro-2, 5- 4-ethyIphenyl 381 dimethylphenoxy 4-chloro-2, 5- 2 , 3 -difluorophenyl 389 dimethylphenoxy 4-chloro-2, 5- 2 , 6-dimethoxyphenyl 413 dimethylphenoxy 4-chloro-2, 5- 3 , 4-difluorophenyl 389 dimethylphenoxy 4-chloro-2, 5- 2 , 5-difluorophenyl 389 dimethylphenoxy 4-chloro-2, 5- 4-ethoxyphenyl 397 dimethylphenoxy 4-chloro-2, 5- 2,4, 6-trichlorophenyl 456 dimethylphenoxy 4-chloro-2, 5- 3 -methylphenyl 367 dimethylphenoxy 4-chloro-2, 5- 2-fluoro-5- 439 dimethylphenoxy ( trifluoromethyl ) phenyl 4-chloro-2, 5- 3-methoxyphenyl 383 dimethylphenoxy 4-chloro-2, 5- 2-bromophenyl 432 di ethylphenoxy 4-chloro-2 , 5- 4-bromophenyl 432 dimethylphenoxy 4-chloro-2, 5- 4-fluoro-3- 439 dimethylphenoxy ( trifluoromethyl ) phenyl 4-chloro-2, 5- 3- (trifluoromethoxy) phenyl 437 dimethylphenoxy 4-chloro-2, 5- 9-fluorenon-4-yl 455 dimethylphenoxy 4-chloro-2, 5- isoxazol-5-yl 344 dimethylphenoxy 4-chloro-2, 5- benzofuroxan-5-yl 411 dimethylphenoxy 4-chloro-2, 5- 2-chloropyrid-3-yl 388 dimethylphenoxy 4-chloro-2, 5- 2-(4- 460 dimethylphenoxy methylphenoxy) pyridin-3-yl 4-chloro-2, 5- pyridin-4-yl 354 dimethylphenoxy 4-chloro-2, 5- anthraquinon-2-yl 483 dimethylphenoxy 4-chloro-2, 5- 2-iodophenyl 479 dimethylphenoxy 4-chloro-2, 5- 4-pentyIphenyl 423 dimethylphenoxy 4-chloro-2, 5- 2-(4-chlorophenylthio) 496 dimethylphenoxy pyridin-3-yl 4-chloro-2, 5- 2,6-dimethylphenyl 381 dimethylphenoxy 4-chloro-2, 5- 2 , 5-dimethoxyphenyl 413 dimethylphenoxy 4-chloro-2, 5- 2, 5-dichloropyridin-3-yl 423 dimethylphenoxy 4-chloro-2, 5- 2-chloro-6-methoxypyridin- 418 dimethylphenoxy 4-yl 4-chloro-2, 5- 2 , 3-dichloropyridin-5-yl 423 dimethylphenoxy 4-chloro-2, 5- 1-naphthyl 417 dimethylphenoxy 4-chloro-2, 5- 2,4-dimethoxyphenyl 413 dimethylphenoxy 4-chloro-2, 5- 3, 5-bis (trifluoromethyl) 489 dimethylphenoxy phenyl 4-chloro-2, 5- 2-(4- 480 dimethylphenoxy chlorophenoxy) pyridin-3-yl 4-chloro-2, 5- pentafluorophenyl 443 dimethylphenoxy 4-methoxyphenoxy 3 , 4-dimethoxyphenyl 380 4-methoxyphenoxy 2- (trifluoromethyl) phenyl 388 4-methoxyphenoxy 2 , 4-difluorophenyl 356 4-methoxyphenoxy 3- (trifluoromethyl) phenyl 388 4-methoxyphenoxy 2-naphthyl 370 4-methoxyphenoxy 2-methoxyphenyl 350 4-methoxyphenoxy 3,4,5-trimethyIphenyl 410 4-methoxyphenoxy 3,4-dichlorophenyl 389 4-methoxyphenoxy 3 -bromophenyl 399 4-methoxyphenoxy 3-pyridyl 321 4-methoxyphenoxy 2-ethoxynaphth-l-yl 414 4-methoxyphenoxy 2, 3-dichlorophenyl 389 4-methoxyphenoxy 6-chloropyrid-3-yl 356 4-methoxyphenoxy 4- (trifluoromethoxy) phenyl 404 4-methoxyphenoxy 2-fluoro-4- 406 ( trifluoromethyl ) phenyl 4-methoxyphenoxy 3 -bromothienyl 405 -methoxyphenoxy 2-acetoxyphenyl 378 -methoxyphenoxy 5-methylisoxazol-3-yl 325 -methoxyphenoxy 2- (phenylthio) pyrid-3-yl 429 -methoxyphenoxy 2- (trifluoromethoxy) phenyl 404 -methoxyphenoxy l-phenyl-5-propylpyrazin- 428 4-yl -methoxyphenoxy 2-ethoxyphenyl 364 -methoxyphenoxy 3-chlorothien-2-yl 361 -methoxyphenoxy l-(2-(2-methyl)propyl)-3- 380 methylpyrazol-5-yl -methoxyphenoxy 3 , 5-dichlorophenyl 389 -methoxyphenoxy 2- (propylthio) pyridin-3-yl 395 -methoxyphenoxy 2- (ethylthio) pyridin-3-yl 381 -methoxyphenoxy 3-bromopyridin-5-yl 400 -methoxyphenoxy 4-methyl-l, 2, 3-thiadiazol- 342 5-yl -methoxyphenoxy l-methyl-3-(2-(2- 380 methyl ) propyl ) pyrazol-5-yl -methoxyphenoxy 3-chlorobenzo [b] thiophen- 411 2-yl -methoxyphenoxy 4-chlorophenyl 355 -methoxyphenoxy 4-methyl-2-phenyl-l,2,3- 401 triazol-5-yl -methoxyphenoxy benzo [b] thiophen-2-yl 376 -methoxyphenoxy 3, 4-dimethyIphenyl 348 -methoxyphenoxy 2- (phenoxy) pyridin-3 -yl 413 -methoxyphenoxy 2- (methylthio) pyridin-3-yl 367 -methoxyphenoxy 5-methyl-3-phenylisoxazol- 401 4-yl -methoxyphenoxy 4-chloro-1,3 -dimethyl 424 pyrazolo [3 , 4-b]pyridin-3- yi -methoxyphenoxy 2-chloro-6-methylpyridin- 370 4-yl -methoxyphenoxy 3 , 5-dimethylisoxazol-4-yl 339 -methoxyphenoxy 1-naphthyl 370 -methoxyphenoxy 2-fluorophenyl 338 -methoxyphenoxy 4-propyIphenyl 362 -methoxyphenoxy 3-fluorophenyl 338 -methoxyphenoxy 2 , 6-difluorophenyl 356 -methoxyphenoxy 2-chlorophenyl 355 -methoxyphenoxy 3- (chloromethyl )phenyl 369 -methoxyphenoxy 4-(2-(2- 376 methyl ) propyl ) phenyl -methoxyphenoxy 3 -chlorophenyl 355 -methoxyphenoxy 3 , 5-dimethoxyphenyl 380 -methoxyphenoxy 2, 6-dichlorophenyl 389 -methoxyphenoxy 2, 4-dichlorophenyl 389 -methoxyphenoxy 4-fluorophenyl 338 -methoxyphenoxy 4-butylphenyl 376 -methoxyphenoxy 2 -methylphenyl 334 -methoxyphenoxy phenyl 320 -methoxyphenoxy 4-ethylphenyl 348 -methoxyphenoxy 2 , 3-difluorophenyl 356 -methoxyphenoxy 2 , 6-dimethoxyphenyl 380 -methoxyphenoxy 3 , 4-difluorophenyl 356 -methoxyphenoxy 2 , 5-difluorophenyl 356 -methoxyphenoxy 4-ethoxyphenyl 364 -methoxyphenoxy 2,4, 6-trichlorophenyl 424 -methoxyphenoxy 3 -methylphenyl 334 -methoxyphenoxy 2-fluoro-5- 406 ( trifluoromethyl ) phenyl -methoxyphenoxy 3-methoxyphenyl 350 -methoxyphenoxy 2-bromophenyl 399 -methoxyphenoxy 4-bromophenyl 399 -methoxyphenoxy 4-fluoro-3- 406 ( trifluoromethyl) phenyl -methoxyphenoxy 3- (trifluoromethoxy) phenyl 404 -methoxyphenoxy 9-fluorenon-4-yl 422 -methoxyphenoxy isoxazol-5-yl 311 -methoxyphenoxy benzofuroxan-5-yl 378 -methoxyphenoxy 2-chloropyrid-3 -y1 356 -methoxyphenoxy 2-(4- 427 methylphenoxy) pyridin-3 -yl -methoxyphenoxy pyridin-4-yl 321 -methoxyphenoxy anthraquinon-2-yl 450 -methoxyphenoxy 2-iodophenyl 446 -methoxyphenoxy 4-pentyIphenyl 390 -methoxyphenoxy 2- (4-chlorophenylthio) 464 pyridin-3-yl -methoxyphenoxy 2 , 6-dimethylphenyl 348 -methoxyphenoxy 2 , 5-dimethoxyphenyl 380 -methoxyphenoxy 2 , 5-dichloropyridin-3-yl 390 -methoxyphenoxy 2-chloro-6-methoxypyridin- 386 4-yl -methoxyphenoxy 2, 3-dichloropyridin-5-yl 390 -methoxyphenoxy 1-naphthyl 384 -methoxyphenoxy 2, 4-dimethoxyphenyl 380 -methoxyphenoxy 3, 5-bis (trifluoromethyl) 456 phenyl -methoxyphenoxy 2-(4- 448 chlorophenoxy) pyridin-3 -yl -methoxyphenoxy pentafluorophenyl 410 - -propoxy) phenoxy 3 , 4-dimethoxyphenyl 408 - -propoxy) phenoxy 2- (trifluoromethyl) phenyl 416 - -propoxy) phenoxy 2, 4-difluorophenyl 384 - -propoxy) phenoxy 3- (trifluoromethyl) phenyl 416 - -propoxy) phenoxy 2 -naphthyl ' 398 - -propoxy) phenoxy 2-methoxyphenyl 378 - ( 2 -propoxy) phenoxy 3,4, 5-trimethyIphenyl 438 - 2 -propoxy) phenoxy 3 , 4-dichlorophenyl 417 - 2 -propoxy) phenoxy 3 -bromophenyl 427 - 2 -propoxy) phenoxy 3 -pyridyl 349 - 2 -propoxy) phenoxy 2-ethoxynaphth-l-yl 442 - 2 -propoxy) phenoxy 2, 3 -dichlorophenyl 417 - 2-propoxy) phenoxy 6-chloropyrid-3-yl 384 - 2-propoxy) phenoxy 4- (trifluoromethoxy) phenyl 432 - 2-propoxy) phenoxy 2-fluoro-4- 434 (trifluoromethyl) phenyl - 2 -propoxy) phenoxy 3-bromothienyl 433 - 2 -propoxy) phenoxy 2-acetoxyphenyl 406 - 2 -propoxy) phenoxy 5-methylisoxazol-3-yl 353 - 2 -propoxy) phenoxy 2- (phenylthio) pyrid-3-yl 458 - 2 -propoxy) phenoxy 2- (trifluoromethoxy) phenyl 432 - 2-propoxy) phenoxy 1-phenyl- 5-propylpyrazin- 457 4-yl - 2-propoxy) phenoxy 2-ethoxyphenyl 392 - 2-propoxy) phenoxy 3-chlorothien-2-yl 389 - 2-propoxy) phenoxy l-(2-(2-methyl)propyl)-3- 408 methylpyrazol-5-yl - -propoxy) phenoxy 3 , 5-dichlorophenyl 417 - -propoxy)phenoxy 2- (propylthio)pyridin-3-yl 423 - -propoxy) phenoxy 2- (ethylthio)pyridin-3-yl 409 - 2-propoxy) phenoxy 3-bromopyridin-5-yl 428 - 2-propoxy) phenoxy 4-methyl-l, 2, 3-thiadiazol- 370 5-yl - 2-propoxy) phenoxy l-methyl-3-(2-(2- 408 methyl)propyl)pyrazol-5-yl - 2-propoxy)phenoxy 3-chlorobenzo[b] thiophen- 439 2-yl - 2-propoxy)phenoxy 4-chlorophenyl 383 - 2-propoxy) phenoxy 4-methyl-2-phenyl-l,2,3- 429 triazol-5-yl - 2-propoxy) phenoxy benzo [b] thiophen-2-yl 404 - 2-propoxy)phenoxy 3 , 4-dimethylphenyl 376 - 2-propoxy)phenoxy 2- (phenoxy)pyridin-3-yl 441 - 2-propoxy)phenoxy 2- (methylthio)pyridin-3-yl 395 - 2-propoxy)phenoxy 5-methyl-3-phenylisoxazol- 429 4-yl 2-propoxy) phenoxy 4-chloro-l, 3-dimethyl 452 pyrazolo [3, 4-b]pyridin-3- yi 2-propoxy)phenoxy 2-chloro-6-methylpyridin- 398 4-yl - 2-propoxy) phenoxy 3 , 5-dimethylisoxazol-4-yl 367 - 2-propoxy) phenoxy 1-naphthyl 398 - propoxy) phenoxy 2 -fluorophenyl 366 - -propoxy) phenoxy 4-propyIphenyl 390 - -propoxy) phenoxy 3 - fluorophenyl 366 - -propoxy) phenoxy 2 , 6-difluorophenyl 384 - -propoxy) phenoxy 2 -chlorophenyl 383 - -propoxy) phenoxy 3 - (chloromethyl ) phenyl 397 - -propoxy) phenoxy 4-(2-(2- 404 methyl ) propyl) phenyl -(2 -propoxy) phenoxy 3 -chlorophenyl 383 - 2-propoxy) phenoxy 3 , 5-dimethoxyphenyl 408 - 2-propoxy) phenoxy 2 , 6-dichlorophenyl 417 - 2-propoxy) phenoxy 2 , 4-dichlorophenyl 417 - 2-propoxy) phenoxy 4-fluorophenyl 366 - 2-propoxy) phenoxy 4-butyIphenyl 404 - 2-propoxy) phenoxy 2-methylphenyl 362 - 2-propoxy) phenoxy phenyl 348 - 2-propoxy) phenoxy 4-ethyIphenyl 376 - 2-propoxy) phenoxy 2 , 3-difluorophenyl 384 - 2-propoxy) phenoxy 2 , 6-dimethoxyphenyl 408 - 2-propoxy) phenoxy 3 , 4-difluorophenyl 384 - 2-propoxy)phenoxy 2 , 5-difluorophenyl 384 - 2-propoxy) phenoxy 4-ethoxyphenyl 392 - ( 2-propoxy) phenoxy 2,4, 6-trichlorophenyl 452 - ( 2-propoxy) phenoxy 3 -methylphenyl 362 - ( 2-propoxy) phenoxy 2-fluoro-5- 434 ( trifluoromethyl) phenyl - ( 2-propoxy) phenoxy 3-methoxyphenyl 378 - ( 2-propoxy) phenoxy 2-bromophenyl 427 -< 2 -propoxy) phenoxy 4-bromophenyl 427 -( 2 -propoxy) phenoxy 4-fluoro-3- 434 ( trifluoromethyl ) phenyl -( 2 -propoxy) phenoxy 3- (trifluoromethoxy) phenyl 432 -( 2 -propoxy) phenoxy 9 - fluorenon-4-yl 450 -( 2 -propoxy) phenoxy isoxazol-5-yl 339 -( 2 -propoxy) phenoxy benzofuroxan-5-yl 406 -( 2 -propoxy) phenoxy 2-chloropyrid-3-yl 384 -( 2 -propoxy) phenoxy 2-(4- 455 ethylphenoxy) pyridin-3 -y1 -( 2 -propoxy) phenoxy pyridin-4-yl 349 -( 2 -propoxy) phenoxy anthraquinon-2-y1 478 - ( 2 -propoxy) phenoxy 2-iodophenyl 474 -( 2 -propoxy) phenoxy 4-pentyIphenyl 419 -( 2 -propoxy) phenoxy 2- (4-chlorophenylthio) 492 pyridin-3-yl - 2 -propoxy) phenoxy 2 , 6-dimethylphenyl 376 - 2 -propoxy) phenoxy 2 , 5-dimethoxyphenyl 408 - 2 -propoxy) phenoxy 2, 5-dichloropyridin-3-yl 418 - 2 -propoxy) phenoxy 2 -chloro-6-methoxypyridin- 414 4-yl - ( 2 -propoxy) phenoxy 2 , 3-dichloropyridin-5-yl 418 - ( 2 -propoxy) phenoxy 1-naphthyl 412 - ( 2-propoxy) phenoxy 2 , 4-dimethoxyphenyl 408 - ( 2-propoxy) phenoxy 3 , 5-bis (trifluoromethyl) 484 phenyl 2 -propoxy ) phenoxy 2-(4- 476 chlorophenoxy) yridin-3 -yl - 2 -propoxy) phenoxy pentafluorophenyl 438 - fluorophenoxy 3 , 4-dimethoxyphenyl 368 -fluorophenoxy 2- (trifluoromethyl) phenyl 376 - fluorophenoxy 2, 4-difluorophenyl 344 -fluorophenoxy 3- (trifluoromethyl) phenyl 376 -fluorophenoxy 2-naphthyl 358 -fluorophenoxy 2 -methoxyphenyl 338 -fluorophenoxy 3, 4, 5-trimethyIphenyl 398 -fluorophenoxy 3 , 4-dichlorophenyl 377 -fluorophenoxy 3-bromophenyl 387 -fluorophenoxy 3 -pyridyl 309 -fluorophenoxy 2-ethoxynaphth-l-yl 402 -fluorophenoxy 2, 3-dichlorophenyl 377 -fluorophenoxy 6-chloropyrid-3-yl 344 -fluorophenoxy 4- (trifluoromethoxy) phenyl 392 -fluorophenoxy 2-fluoro-4- 394 ( trifluoromethyl ) phenyl -fluorophenoxy 3-bromothienyl 393 -fluorophenoxy 2-acetoxyphenyl 366 -fluorophenoxy 5-methylisoxazol-3-yl 313 -fluorophenoxy 2- (phenylthio)pyrid-3-yl 417 -f1uorophenoxy 2- (trifluoromethoxy) phenyl 392 -fluo ophenoxy l-phenyl-5-propylpyrazin- 416 4-yl -fluorophenoxy 2-ethoxyphenyl 352 -fluorophenoxy 3-chlorothien-2-yl 349 -fluorophenoxy l-(2-(2-methyl)propyl)-3- 368 methylpyrazol-5-yl -fluorophenoxy 3 , 5-dichlorophenyl 377 -fluorophenoxy 2- (propylthio)pyridin-3-yl 383 -fluorophenoxy 2- (ethylthio)pyridin-3-yl 369 -fluorophenoxy 3-bromopyridin-5-yl 388 -fluorophenoxy 4-methyl-l, 2, 3-thiadiazol- 330 5-yl -fluorophenoxy l-methyl-3-(2-(2- 368 methyl ) propyl ) pyrazol-5 -yl - fluorophenoxy 3-chlorobenzo[b] thiophen- 399 2-yl - fluorophenoxy 4-chlorophenyl 343 -fluorophenoxy 4-methyl-2-phenyl-l,2,3- 389 triazol-5-yl -fluorophenoxy benzo [b] thiophen-2-yl 364 - f1uorophenoxy 3 , 4-dimethylphenyl 336 -fluorophenoxy 2- (phenoxy) yridin-3 -yl 401 -fluorophenoxy 2- (methylthio) yridin-3-yl 355 -fluorophenoxy 5-methyl-3-phenylisoxazol- 389 4-yl -fluorophenoxy 4-chloro-1,3 -dimethyl 412 pyrazolo [3, 4-b]pyridin-3- yi - f1uorophenoxy 2-chloro-6-methylpyridin- 358 4-yl -fluorophenoxy 3, 5-dimethylisoxazol-4-yl 327 -fluorophenoxy 1-naphthyl 358 -fluorophenoxy 2-fluorophenyl 326 -fluorophenoxy 4-propyIphenyl 350 -fluorophenoxy 3 -fluorophenyl 326 -fluorophenoxy 2 , 6-difluorophenyl 344 -fluorophenoxy 2 -chlorophenyl 343 -fluorophenoxy 3- ( chloromethyl) phenyl 357 -fluorophenoxy 4-(2-(2- 364 methyl ) propyl ) phenyl -fluorophenoxy 3 -chlorophenyl 343 - fluorophenoxy 3 , 5-dimethoxyphenyl 368 -fluorophenoxy 2 , 6-dichlorophenyl 377 -fluorophenoxy 2 , 4-dichlorophenyl 377 -fluorophenoxy 4-fluorophenyl 326 -fluorophenoxy 4-butyIphenyl 364 -fluorophenoxy 2-methylphenyl 322 -fluorophenoxy phenyl 308 -fluorophenoxy 4-ethylphenyl 336 -fluorophenoxy 2, 3-difluorophenyl 344 -fluorophenoxy 2, 6-dimethoxyphenyl 368 -fluorophenoxy 3 , 4-difluorophenyl 344 -fluorophenoxy 2 , 5-difluorophenyl 344 -fluorophenoxy 4-ethoxyphenyl 352 -f1uorophenoxy 2, 4, 6-trichlorophenyl 412 -fluorophenoxy 3-methylphenyl 322 -fluorophenoxy 2-fluoro-5- 394 ( trifluoromethyl ) phenyl -fluorophenoxy 3-methoxyphenyl 338 -fluorophenoxy 2-bromophenyl 387 -fluorophenoxy 4-bromophenyl 387 -fluorophenoxy 4-fluoro-3- 394 ( trifluoromethyl) phenyl -fluorophenoxy 3- ( trifluoromethoxy) phenyl 392 -fluorophenoxy 9-fluorenon-4-yl 410 -fluorophenoxy isoxazol-5-yl 299 -fluorophenoxy benzofuroxan-5-yl 366 -fluorophenoxy 2-chloropyrid-3-yl 344 -fluorophenoxy 2-(4- 415 methylphenoxy) pyridin-3 -yl -fluorophenoxy pyridin-4-yl 309 -fluorophenoxy anthraquinon-2-yl 438 -fluorophenoxy 2-iodophenyl 434 -fluorophenoxy 4-pentylphenyl 378 -fluorophenoxy 2- (4-chlorophenylthio) 452 pyridin-3-yl -fluorophenoxy 2 , 6-dimethylphenyl 336 -fluorophenoxy 2 , 5-dimethoxyphenyl 368 -fluorophenoxy 2 , 5-dichloropyridin-3-yl 378 -f1uorophenoxy 2-chloro-6-methoxypyridin- 374 4-yl -f1uorophenoxy 2 , 3-dichloropyridin-5-yl 378 -fluorophenoxy 1-naphthyl 372 -fluorophenoxy 2 , 4-dimethoxyphenyl 368 -fluorophenoxy 3.5- 444 bis (trifluoromethyl)phenyl -fluorophenoxy 2-(4- 436 chlorophenoxy)pyridin-3-yl -fluorophenoxy pentafluorophenyl 398 -chlorophenoxy 3 , 4-dimethoxyphenyl 385 -chlorophenoxy 2- (trifluoromethyl) phenyl 393 -chlorophenoxy 2, 4-difluorophenyl 361 -chlorophenoxy 3- (trifluoromethyl) phenyl 393 -chlorophenoxy 2-naphthyl 375 -chlorophenoxy 2 -methoxyphenyl 355 -chlorophenoxy 3, 4, 5-trimethylphenyl 415 -chlorophenoxy 3, 4-dichlorophenyl 394 -chlorophenoxy 3 -bromophenyl 404 -chlorophenoxy 3-pyridyl 326 -chlorophenoxy 2-ethoxynaphth-l-yl 419 -chlorophenoxy 2, 3 -dichlorophenyl 394 -chlorophenoxy 6-chloropyrid-3-yl 360 -chlorophenoxy 4- (trifluoromethoxy) phenyl 409 -chlorophenoxy 2-fluoro-4- 411 ( trifluoromethyl ) phenyl -chlorophenoxy 3-bromothienyl 410 -chlorophenoxy 2-acetoxyphenyl 383 -chlorophenoxy 5-methylisoxazol-3-yl 330 -chlorophenoxy 2- (phenylthio)pyrid-3-yl 434 -chlorophenoxy 2- (trifluoromethoxy) phenyl 409 -chlorophenoxy l-phenyl-5-propylpyrazin- 433 4-yl -chlorophenoxy 2-ethoxyphenyl 369 -chlorophenoxy 3-chlorothien-2-yl 365 -chlorophenoxy l-(2-(2-methyl)propyl)-3- 385 methylpyrazol-5-yl -chlorophenoxy 3 , 5 -dichlorophenyl 394 -chlorophenoxy 2- (propylthio) pyridin-3-yl 400 -chlorophenoxy 2- (ethylthio) pyridin-3 -yl 386 -chlorophenoxy 3-bromopyridin-5-yl 405 -chlorophenoxy 4-methyl-l, 2, 3-thiadiazol- 347 5-yl -chlorophenoxy l-methyl-3-(2-(2- 385 methyl ) propyl ) pyrazol- 5-yl -chlorophenoxy 3-chlorobenzo[b] thiophen- 415 2-yl -chlorophenoxy 4-chlorophenyl 359 -chlorophenoxy 4-methyl-2-phenyl-l,2,3- 406 triazol-5-yl -chlorophenoxy benzo [b] thiophen-2-yl 381 -chlorophenoxy 3 , 4-dimethylphenyl 353 -chlorophenoxy 2- (phenoxy) pyridin-3-yl 418 -chlorophenoxy 2- (methylthio) pyridin-3-yl 372 -chlorophenoxy 5-methyl-3-phenylisoxazol- 406 4-yl -chlorophenoxy 4-chloro-l, 3 -dimethyl 428 pyrazolo [3 , 4-b]pyridin-3- yi -chlorophenoxy 2-chloro-6-methylpyridin- 374 4-yl -chlorophenoxy 3 , 5-dimethylisoxazol-4-yl 344 -chlorophenoxy 1-naphthyl 375 -chlorophenoxy 2- fluorophenyl 343 -chlorophenoxy 4-propyIphenyl 367 -chlorophenoxy 3 -fluorophenyl 343 -chlorophenoxy 2, 6-difluorophenyl 361 -chlorophenoxy 2 -chlorophenyl 359 -chlorophenoxy 3- (chloromethyl) phenyl 373 -chlorophenoxy 4-(2-(2- 381 methyl ) propyl ) phenyl -chlorophenoxy 3 -chlorophenyl 359 -chlorophenoxy 3 , 5-dimethoxyphenyl 385 -chlorophenoxy 2, 6 -dichlorophenyl 394 -chlorophenoxy 2, 4-dichlorophenyl 394 -chlorophenoxy 4- fluorophenyl 343 -chlorophenoxy 4-butylphenyl 381 -chlorophenoxy 2 -methylphenyl 339 -chlorophenoxy phenyl 325 -chlorophenoxy 4-ethylphenyl 353 -chlorophenoxy 2, 3-difluorophenyl 361 -chlorophenoxy 2, 6 -dimethoxyphenyl 385 -chlorophenoxy 3 , 4-difluorophenyl 361 -chlorophenoxy 2, 5-difluorophenyl 361 -chlorophenoxy 4-ethoxyphenyl 369 -chlorophenoxy 2,4,6-trichlorophenyl 428 -chlorophenoxy 3 -methylphenyl 339 -chlorophenoxy 2-fluoro-5- 411 ( trifluoromethyl ) phenyl -chlorophenoxy 3 -methoxyphenyl 355 -chlorophenoxy 2-bromophenyl 404 -chlorophenoxy 4-bromophenyl 404 -chlorophenoxy 4-fluoro-3- 411 ( trifluoromethyl ) phenyl -chlorophenoxy 3- (trifluoromethoxy) phenyl 409 -chlorophenoxy 9-fluorenon-4-yl 427 -chlorophenoxy isoxazol-5-yl 316 -chlorophenoxy benzofuroxan-5-yl 383 -chlorophenoxy 2-chloropyrid-3-yl 360 -chlorophenoxy 2-(4- 432 methylphenoxy)pyridin-3-yl -chlorophenoxy pyridin-4-yl 326 -chlorophenoxy anthraquinon-2-yl 455 -chlorophenoxy 2-iodophenyl 451 -chlorophenoxy 4-pentyIphenyl 395 -chlorophenoxy 2- (4-chlorophenylthio) 468 pyridin-3-yl -chlorophenoxy 2 , 6-dimethylphenyl 353 -chlorophenoxy 2 , 5-dimethoxyphenyl 385 -chlorophenoxy 2 , 5-dichloropyridin-3-yl 395 -chlorophenoxy 2-chloro-6-methoxypyridin- 390 4-yl -chlorophenoxy 2, 3-dichloropyridin-5-yl 395 -chlorophenoxy 1-naphthyl 389 -chlorophenoxy 2 , 4-dimethoxyphenyl 385 -chlorophenoxy 3,5- 461 bis ( trifluoromethyl ) phenyl -chlorophenoxy 2-(4- 452 chlorophenoxy) pyridin-3 -yl -chlorophenoxy pentafluorophenyl 415 , 4-difluorophenoxy 3 , 4-dimethoxyphenyl 386 , 4-difluorophenoxy 2- (trifluoromethyl) phenyl 394 , 4-difluorophenoxy 2, 4-difluorophenyl 362 , 4-difluorophenoxy 3- (trifluoromethyl) phenyl 394 , 4-difluorophenoxy 2 -naphthyl 376 , 4-difluorophenoxy 2 -methoxyphenyl 356 , 4-difluorophenoxy 3, 4, 5-trimethylphenyl 416 , 4-difluorophenoxy 3, 4-dichlorophenyl 395 , 4-difluorophenoxy 3 -bromophenyl 405 , 4-difluorophenoxy 3 -pyridyl 327 , 4-difluorophenoxy 2-ethoxynaphth-l-yl 420 , 4-difluorophenoxy 2, 3 -dichlorophenyl 395 , 4-difluorophenoxy 6-chloropyrid-3-yl 362 , 4-difluorophenoxy 4- (trifluoromethoxy) phenyl 410 , 4-difluorophenoxy 2-fluoro-4- 412 ( trifluoromethyl ) phenyl , 4-difluorophenoxy 3-bromothienyl 411 , 4-difluorophenoxy 2-acetoxyphenyl 384 , 4-difluorophenoxy 5-methylisoxazol-3-yl 331 , 4-difluorophenoxy 2- (phenylthio)pyrid-3-yl 435 , 4-difluorophenoxy 2- (trifluoromethoxy) phenyl 410 , 4-difluorophenoxy l-phenyl-5-propylpyrazin- 434 4-yl , 4-difluorophenoxy 2-ethoxyphenyl 370 , 4-difluorophenoxy 3-chlorothien-2-yl 367 , 4-difluorophenoxy l-(2-(2-methyl)propyl)-3- 386 methylpyrazol-5-yl , 4-difluorophenoxy 3 , 5-dichlorophenyl 395 , 4-difluorophenoxy 2- (propylthio) pyridin-3-yl 401 , 4-difluorophenoxy 2- (ethylthio) pyridin-3-yl 387 , 4-difluorophenoxy 3-bromopyridin-5-yl 406 , 4-difluorophenoxy 4-methyl-l, 2, 3-thiadiazol- 348 5-yl , 4-difluorophenoxy l-methyl-3-(2-(2- 386 methyl ) propyl ) pyrazol-5-yl , 4-difluorophenoxy 3-chlorobenzo [b] thiophen- 417 2-yl , 4-difluorophenoxy 4-chlorophenyl 361 , 4-difluorophenoxy 4-methyl-2-phenyl-l,2,3- 407 triazol-5-yl , 4-difluorophenoxy benzo [b] thiophen-2-yl 382 , 4-difluorophenoxy 3 , 4-dimethylphenyl 354 , 4-difluorophenoxy 2- (phenoxy) pyridin-3 -yl 409 , 4-difluorophenoxy 2- (methylthio) pyridin-3-yl 373 , 4-difluorophenoxy 5-methyl-3-phenylisoxazol- 407 4-yl , 4-difluorophenoxy 4-chloro-l, 3-dimethyl 430 pyrazolo [3 , 4-b]pyridin-3- yi , 4-difluorophenoxy 2-chloro-6-methylpyridin- 376 4-yl , 4-difluorophenoxy 3 , 5-dimethylisoxazol-4-yl 345 , 4-difluorophenoxy 1-naphthyl 376 , 4-difluorophenoxy 2-fluorophenyl 344 , 4-difluorophenoxy 4-propylphenyl 368 , 4-difluorophenoxy 3-fluorophenyl 344 , 4-difluorophenoxy 2 , 6-difluorophenyl 362 , 4-difluorophenoxy 2-chlorophenyl 361 , 4-difluorophenoxy 3 - ( chloromethyl ) phenyl 375 , 4-difluorophenoxy 4-(2-(2- 382 methyl ) propyl ) phenyl , 4-difluorophenoxy 3 -chlorophenyl 361 , 4-difluorophenoxy 3 , 5-dimethoxyphenyl 386 , 4-difluorophenoxy 2 , 6-dichlorophenyl 395 , 4-difluorophenoxy 2 , 4-dichlorophenyl 392 , 4-difluorophenoxy 4-fluorophenyl 344 , 4-difluorophenoxy 4-butylphenyl 382 , 4-difluorophenoxy 2-methylphenyl 340 , 4-difluorophenoxy phenyl 326 , 4-difluorophenoxy 4-ethylphenyl 354 , 4-difluorophenoxy 2 , 3 -difluorophenyl 362 , 4-difluorophenoxy 2 , 6-dimethoxyphenyl 386 , 4-difluorophenoxy 3 , 4-difluorophenyl 362 , 4-difluorophenoxy 2 , 5-difluorophenyl 362 , 4-difluorophenoxy 4-ethoxyphenyl 370 , 4-difluorophenoxy 2,4, 6-trichlorophenyl 430 , 4-difluorophenoxy 3 -methylphenyl 340 , 4-difluorophenoxy 2-fluoro-5- 412 ( trifluoromethyl ) phenyl , 4-difluorophenoxy 3-methoxyphenyl 356 , 4-difluorophenoxy 2-bromophenyl 405 , 4-difluorophenoxy 4-bromophenyl 405 , 4-difluorophenoxy 4-fluoro-3- 412 ( tri luoromethyl ) phenyl , 4-difluorophenoxy 3- (trifluoromethoxy) phenyl 410 , 4-difluorophenoxy 9-fluorenon-4-yl 428 , 4-difluorophenoxy isoxazol-5-yl 317 , 4-difluorophenoxy benzofuroxan-5-y1 384 , 4-difluorophenoxy 2-chloropyrid-3-yl 362 , 4-difluorophenoxy 2-(4- 433 methylphenoxy) pyridin-3-yl , 4-difluorophenoxy pyridin-4-yl 327 , 4-difluorophenoxy anthraquinon-2-yl 456 , 4-difluorophenoxy 2-iodophenyl 452 , 4-difluorophenoxy 4-pentylphenyl 396 , 4-difluorophenoxy 2- (4-chlorophenylthio) 470 pyridin-3 -yl , 4-difluorophenoxy 2 , 6-dimethylphenyl 354 , 4-difluorophenoxy 2, 5-dimethoxyphenyl 386 , 4-difluorophenoxy 2 , 5-dichloropyridin-3-yl 396 , 4-difluorophenoxy 2-chloro-6-methoxypyridin- 392 4-yl , 4-difluorophenoxy 2 , 3-dichloropyridin-5-yl 396 , 4-difluorophenoxy 1-naphthyl 390 , 4-difluorophenoxy 2 , 4-dimethoxyphenyl 386 , 4-difluorophenoxy 3,5- 462 bis (trifluoromethyl) phenyl , 4-difluorophenoxy 2-(4- 454 chlorophenoxy) pyridin-3 -y1 , 4-difluorophenoxy pentafluorophenyl 416 -thiomethylphenoxy 3 , 4-dimethoxyphenyl 396 -thiomethylphenoxy 2- (trifluoromethyl) phenyl 404 -thiomethylphenoxy 2, 4-difluorophenyl 372 -thiomethylphenoxy 3- (trifluoromethyl) phenyl 404 -thiomethylphenoxy 2 -naphthyl 386 -thiomethylphenoxy 2 -methoxyphenyl 366 -thiomethylphenoxy 3,4, 5, -trimethyIphenyl 426 -thiomethylphenoxy 3 , 4-dichlorophenyl 405 -thiomethylphenoxy 3 -bromophenyl 415 -thiomethylphenoxy 3 -pyridyl 337 -thiomethylphenoxy 2-ethoxynaphth-l-yl 430 -thiomethylphenoxy 2, 3-dichlorophenyl 405 -thiomethylphenoxy 6-chloropyrid-3-yl 372 -thiomethylphenoxy 4- (trifluoromethoxy) phenyl 420 -thiomethylphenoxy 2-fluoro-4- 422 ( trifluoromethyl ) phenyl -thiomethylphenoxy 3-bromothienyl 421 -thiomethylphenoxy 2-acetoxyphenyl 394 -thiomethylphenoxy 5-methylisoxazol-3-yl 341 -thiomethylphenoxy 2- (phenylthio) pyrid-3-yl 446 -thiomethylphenoxy 2- ( trifluoromethoxy) phenyl 420 -thiomethylphenoxy l-phenyl-5-propylpyrazin- 445 4-yl -thiomethylphenoxy 2-ethoxyphenyl 380 -thiomethylphenoxy 3-chlorothien-2-yl 377 -thiomethylphenoxy l-(2- (2-methyl) propyl) -3- 396 methylpyrazol-5-yl -thiomethylphenoxy 3 , 5-dichlorophenyl 405 -thiomethylphenoxy 2- (propylthio) pyridin-3-yl 412 -thiomethylphenoxy 2-(ethylthio)pyridin-3-yl 397 -thiomethylphenoxy 3-bromopyridin-5-yl 416 -thiomethylphenoxy 4-methyl-l, 2, 3 -thiadiazol- 358 5-yl -thiomethylphenoxy l-methyl-3-(2-(2- 396 methyl ) propyl ) pyrazol-5-yl -thiomethylphenoxy 3-chlorobenzo[b] thiophen- 427 2-yl -thiomethylphenoxy 4-chlorophenyl 371 -thiomethylphenoxy 4-methyl-2-phenyl-l,2,3- 417 triazol-5-yl -thiomethylphenoxy benzo [b] thiophen-2-yl 392 -thiomethylphenoxy 3, 4-dimethyIphenyl 364 -thiomethylphenoxy 2- (phenoxy) pyridin-3-yl 429 -thiomethylphenoxy 2- (methylthio) pyridin-3-yl 383 -thiomethylphenoxy 5 -methyl-3 -phenylisoxazol- 417 4-yl -thiomethylphenoxy 4-chloro-l, 3 -dimethyl 440 pyrazolo [3 , 4-b]pyridin-3- yi -thiomethylphenoxy 2-chloro-6-methylpyridin- 386 4-yl -thiomethylphenoxy 3 , 5-dimethylisoxazol-4-yl 355 -thiomethylphenoxy 1-naphthyl 386 -thiomethylphenoxy 2 -fluorophenyl 354 -thiomethylphenoxy 4-propylphenyl 378 -thiomethylphenoxy 3 -fluorophenyl 354 -thiomethylphenoxy 2, 6-difluorophenyl 372 -thiomethylphenoxy 2 -chlorophenyl 371 -thiomethylphenoxy 3- (chloromethyl )phenyl 385 -thiomethylphenoxy 4-(2-(2- 392 methyl ) propyl ) phenyl -thiomethylphenoxy 3 -chlorophenyl 371 -thiomethylphenoxy 3 , 5-dimethoxyphenyl 396 -thiomethylphenoxy 2 , 6-dichlorophenyl 405 -thiomethylphenoxy 2 , 4-dichlorophenyl 405 -thiomethylphenoxy 4- fluorophenyl 354 -thiomethylphenoxy 4 -butyIphenyl 392 -thiomethylphenoxy 2 -methylphenyl 350 -thiomethylphenoxy phenyl 336 -thiomethylphenoxy 4-ethyIphenyl 364 -thiomethylphenoxy 2, 3-difluorophenyl 372 -thiomethylphenoxy 2 , 6 -dimethoxyphenyl 396 -thiomethylphenoxy 3 , 4-difluorophenyl 372 -thiomethylphenoxy 2, 5-difluorophenyl 372 -thiomethylphenoxy 4-ethoxyphenyl 380 -thiomethylphenoxy 2, 4, 6-trichlorophenyl 440 -thiomethylphenoxy 3 -methylphenyl 350 -thiomethylphenoxy 2-fluoro-5- 422 ( trifluoromethyl ) phenyl -thiomethylphenoxy 3 -methoxyphenyl 366 -thiomethylphenoxy 2 -bromophenyl 415 -thiomethylphenoxy 4-bromophenyl 415 -thiomethylphenoxy 4-fluoro-3- 422 ( trifluoromethyl ) phenyl -thiomethylphenoxy 3- ( trifluoromethoxy) phenyl 420 -thiomethylphenoxy 9-fluorenon-4-yl 438 -thiomethylphenoxy isoxazol-5-yl 327 -thiomethylphenoxy benzofuroxan-5-yl 394 -thiomethylphenoxy 2-chloropyrid-3-yl 372 -thiomethylphenoxy 2-(4- 443 methylphenoxy)pyridin-3-yl -thiomethylphenoxy pyridin-4-yl 337 -thiomethylphenoxy anthraquinon-2-yl 466 -thiomethylphenoxy 2-iodophenyl 462 -thiomethylphenoxy 4-pentyIphenyl 407 -thiomethylphenoxy 2-(4-chlorophenylthio) 480 pyridin-3 -yl - thiomethylphenoxy 2 , 6-dimethylphenyl 364 4-thiomethylphenoxy 2 , 5-dimethoxyphenyl 396 4-thiomethylphenoxy 2, 5-dichloropyridin-3-yl 406 4-thiomethylphenoxy 2-chloro-6-methoxypyridin- 402 4-yl 4-thiomethylphenoxy 2, 3-dichloropyridin-5-yl 406 4-thiomethylphenoxy 1-naphthyl 400 4-thiomethylphenoxy 2 , 4-dimethoxyphenyl 396 4-thiomethylphenoxy 3,5- 372 bis (trifluoromethyl) phenyl 4-thiomethylphenoxy 2-(4- 464 chlorophenoxy) pyridin-3 -yl 4-thiomethylphenoxy pentafluorophenyl 426 4-(2-(2- 3 , 4-dimethoxyphenyl 406 methyl ) propyl ) phenoxy 4-(2-(2- 2- (trifluoromethyl) phenyl 414 methyl ) propyl ) phenoxy 4-(2-(2- 2 , 4-difluorophenyl 382 methyl ) propyl ) phenoxy 4-(2-(2- 3- (trifluoromethyl) phenyl 414 methyl ) propyl ) phenoxy 4-(2-(2- 2-naphthyl 396 methyl)propyl)phenoxy 4-(2-(2- 2-methoxyphenyl 376 methyl ) propyl ) henoxy 4-(2-(2- 3 , 4, 5-trimethyIphenyl 436 methyl ) propyl ) phenoxy 4-(2-(2- 3 , 4-dichlorophenyl 415 methyl) propyl ) phenoxy 4-(2-(2- 3-bromophenyl 425 methyl ) propyl ) phenoxy 4- (2- (2- 3-pyridyl 347 methyl ) propyl ) phenoxy 4- (2- (2- 2-ethoxynaphth-l-yl 441 methyl ) propyl ) phenoxy 4- (2- (2- 2, 3-dichlorophenyl 415 methyl ) propyl ) phenoxy 4- (2- (2- 6-chloropyrid-3-yl 382 methyl ) propyl) phenoxy 4- (2- (2- 4- (trifluoromethoxy)phenyl 430 methyl ) propyl ) phenoxy 4- (2- (2- 2-fluoro-4- 432 methyl ) propyl) phenoxy ( trifluoromethyl ) phenyl 4- (2- (2- 3-bromothienyl 431 methyl ) propyl)phenoxy 4- (2- (2- 2-acetoxyphenyl 404 methyl ) propyl ) phenoxy 4- (2- (2- 5-methylisoxazol-3-yl 351 methyl ) propyl)phenoxy 4- (2- (2- 2- (phenylthio) pyrid-3-yl 456 methyl ) propyl) phenoxy 4- (2- (2- 2- (trifluoromethoxy)phenyl 430 methyl ) propyl) phenoxy 4- (2- (2- 1-phenyl-5-propylpyrazin- 455 methyl )propyl)phenoxy 4-yl 4- (2- (2- 2-ethoxyphenyl 390 methyl ) propyl ) phenoxy 4- (2- (2- 3-chlorothien-2-yl 387 methyl )propyl)phenoxy 4- (2- (2- l-(2- (2-methyl) propyl) -3- 406 methyl )propyl ) phenoxy methylpyrazol-5-yl 4- (2- (2- 3, 5-dichlorophenyl 415 methyl ) propyl ) phenoxy 4- (2- (2- 2- (propylthio) pyridin-3-yl 422 methyl)propyl) phenoxy 4- (2- (2- 2-(ethylthio)pyridin-3-yl 407 methyl )propyl)phenoxy 4- (2- (2- 3-bromopyridin-5-yl 426 methyl )propyl ) phenoxy 4- (2- (2- 4-methyl-l, 2, 3-thiadiazol- 368 methyl ) propyl ) phenoxy 5-yl 4- (2- (2- l-methyl-3-(2-(2- 406 methyl ) propyl ) phenoxy methyl) propyl ) pyrazol-5-yl 4- (2- (2- 3-chlorobenzo[b] thiophen- 437 methyl ) propyl) phenoxy 2-yl 4- (2- (2- 4-chlorophenyl 381 methyl ) propyl) phenoxy 4- (2- (2- 4-methyl-2-phenyl-l,2,3- 427 methyl )propyl) phenoxy triazol-5-yl 4- (2- (2- benzo [b] thiophen-2-yl 402 methyl) propyl)phenoxy 4- (2- (2- 3 , 4-dimethylphenyl 374 methyl)propyl) henoxy 4- (2- (2- 2- (phenoxy) pyridin-3-yl 439 methyl )propyl )phenoxy 4- (2- (2- 2-(methylthio)pyridin-3-yl 393 methyl) propyl ) henoxy 4- (2- (2- 5-methyl-3-phenylisoxazol- 427 methyl ) propyl ) phenoxy 4-yl 4- (2- (2- 4-chloro-1, 3-dimethyl 450 methyl) propyl ) phenoxy pyrazolo [3, 4-b]pyridin-3- yi 4- (2- (2- 2-chloro-6-methylpyridin- 396 methyl ) propyl ) phenoxy 4-yl 4- (2- (2- 3 , 5-dimethylisoxazol-4-yl 365 methyl ) propyl ) phenoxy 4- (2- (2- 1-naphthyl 396 methyl ) propyl ) phenoxy 4- (2- (2- 2-fluorophenyl 364 methyl ) propyl ) phenoxy 4- ( 2- (2- 4-propyIphenyl 388 methyl ) propyl ) phenoxy 4- (2- (2- 3 -fluorophenyl 364 methyl ) propyl ) phenoxy 4- (2- (2- 2, 6-difluorophenyl 382 methyl ) propyl ) phenoxy 4- (2- (2- 2-chlorophenyl 381 methyl ) propyl ) phenoxy 4- (2- (2- 3- (chloromethyl) phenyl 395 methyl ) propyl ) phenoxy 4-(2-(2- 4-(2-(2- 402 methyl ) propyl ) phenoxy methyl ) propyl ) phenyl 4- (2- (2- 3-chlorophenyl 381 methyl ) propyl ) phenoxy 4- (2- (2- 3, 5-dimethoxyphenyl 406 methyl ) propyl ) phenoxy 4- (2- (2- 2, 6-dichlorophenyl 415 methyl ) propyl ) phenoxy 4- (2- (2- 2, 4-dichlorophenyl 415 methyl ) propyl ) phenoxy 4- (2- (2- 4-fluorophenyl 364 methyl ) propyl ) phenoxy 4- (2- (2- 4-butylphenyl 402 methyl ) propyl ) phenoxy - ( 2- ( 2 - 2 -methylphenyl 360 methyl ) propyl ) phenoxy 4- (2- (2- phenyl 346 methyl ) propyl ) phenoxy 4- (2- (2- 4-ethylphenyl 374 methyl ) propyl ) phenoxy 4- (2- (2- 2, 3 -difluorophenyl 382 methyl ) propyl ) phenoxy 4- (2- (2- 2, 6-dimethoxyphenyl 406 methyl ) propyl ) phenoxy 4- (2- (2- 3, 4-difluorophenyl 382 methyl ) propyl ) phenoxy 4- (2- (2- 2, 5-difluorophenyl 382 methyl ) propyl ) phenoxy 4- (2- (2- 4-ethoxyphenyl 390 methyl ) propyl ) phenoxy 4- (2- (2- 2,4,6-trichlorophenyl 450 methyl ) propyl ) phenoxy 4- (2- (2- 3 -methylphenyl 360 methyl ) propyl ) phenoxy 4- (2- (2- 2-fluoro-5- 432 methyl ) propyl ) phenoxy ( trifluoromethyl ) phenyl 4- (2- (2- 3 -methoxyphenyl 376 methyl ) propyl ) phenoxy 4- (2- (2- 2-bromophenyl 425 methyl ) propyl ) phenoxy 4- (2- (2- 4-bromophenyl 425 methyl ) propyl ) phenoxy 4- (2- (2- 4-fluoro-3- 432 methyl ) propyl ) phenoxy ( trifluoromethyl ) phenyl 4- (2- (2- 3- (trifluoromethoxy) phenyl 430 methyl ) propyl ) phenoxy 4- (2- (2- 9-fluorenon-4-yl 448 methyl ) propyl ) phenoxy 4- (2- (2- isoxazol-5-yl 338 methyl ) propyl ) phenoxy 4- (2- (2- benzofuroxan-5-yl 404 methyl ) propyl ) phenoxy 4- (2- (2- 2-chloropyrid-3-yl 382 methyl ) propyl ) phenoxy 4-(2-(2- 2-(4- 454 methyl ) propyl ) phenoxy methylphenoxy) pyridin-3-yl 4- (2- (2- pyridin-4-yl 347 methyl ) propyl ) phenoxy 4- (2- (2- anthraquinon-2-yl 476 methyl ) propyl ) phenoxy 4- (2- (2- 2-iodophenyl 472 methyl ) propyl ) phenoxy 4- (2- (2- 4-pentyIphenyl 417 methyl ) propyl ) phenoxy 4- (2- (2- 2-(4-chlorophenylthio) 490 methyl ) propyl ) phenoxy pyridin-3 -yl 4- (2- (2- 2, 6-dimethyIphenyl 374 methyl ) propyl ) phenoxy 4- (2- (2- 2, 5-dimethoxyphenyl 406 methyl ) propyl ) phenoxy 4- (2- (2- 2, 5-dichloropyridin-3-yl 416 methyl ) propyl ) phenoxy 4- (2- (2- 2-chloro-6-methoxypyridin- 412 methyl) propyl) phenoxy 4-yl 4_ (2- (2- 2,3-dichloropyridin-5-yl 416 methyl ) propyl ) phenoxy 4- (2- (2- 1-naphthyl 410 methyl ) propyl ) phenoxy 4-(2-(2- 2 , 4-dimethoxyphenyl 406 methyl ) ropyl ) phenoxy 4-(2-(2- 3, 5-bis (trifluoromethyl) 482 methyl ) ropyl ) phenoxy phenyl 4-(2-(2- 2-(4- 474 methyl ) propyl ) phenoxy chlorophenoxy) pyridin-3-yl 4-(2-(2- pentafluorophenyl 436 methyl ) propyl ) phenoxy 2 , 3 -dimethylphenoxy 3 , 4-dimethoxyphenyl 378 2 , 3 -dimethylphenoxy 2- (trifluoromethyl) phenyl 386 2 , 3-dimethylphenoxy 2 , 4-difluorophenyl 354 2 , 3 -dimethylphenoxy 3- (trifluoromethyl )phenyl 386 2 , 3-dimethylphenoxy 2-naphthyl 368 2 , 3 -dimethylphenoxy 2-methoxyphenyl 348 2 , 3 -dimethylphenoxy 3,4, 5-trimethylphenyl 408 2 , 3 -dimethylphenoxy 3 , 4-dichlorophenyl 387 2 , 3 -dimethylphenoxy 3 -bromophenyl 397 2 , 3-dimethylphenoxy 3-pyridyl 319 2 , 3 -dimethylphenoxy 2-ethoxynaphth-l-yl 412 2 , 3 -dimethylphenoxy 2, 3-dichlorophenyl 387 2 , 3-dimethylphenoxy 6-chloropyrid-3-yl 354 2 , 3-dimethylphenoxy 4- (trifluoromethoxy) phenyl 402 2 , 3-dimethylphenoxy 2-fluoro-4- 404 ( trifluoromethyl ) phenyl 2 , 3-dimethylphenoxy 3-bromothienyl 403 2 , 3-dimethylphenoxy 2-acetoxyphenyl 376 2 , 3 -dimethylphenoxy 5-methylisoxazol-3-yl 323 2 , 3-dimethylphenoxy 2- (phenylthio)pyrid-3-yl 427 2 , 3-dimethylphenoxy 2- (trifluoromethoxy) phenyl 402 , 3 -dimethylphenoxy l-phenyl-5-propylpyrazin- 426 4-yl , 3-dimethylphenoxy 2-ethoxyphenyl 362 , 3 -dimethylphenoxy 3-chlorothien-2-yl 359 , 3-dimethylphenoxy 1- (2- (2 -methyl) propyl) -3- 378 methylpyrazol-5-yl , 3 -dimethylphenoxy 3 , 5-dichlorophenyl 387 , 3 -dimethylphenoxy 2- (propylthio) pyridin-3-yl 393 , 3 -dimethylphenoxy 2- (ethylthio) pyridin-3-yl 379 , 3 -dimethylphenoxy 3-bromopyridin-5-yl 398 , 3 -dimethylphenoxy 4-methyl-l, 2, 3-thiadiazol- 340 5-yl , 3 -dimethylphenoxy l-methyl-3-(2-(2- 378 methyl ) propyl ) pyrazol-5-yl , 3 -dimethylphenoxy 3-chlorobenzo[b] thiophen- 409 2-yl , 3-dimethylphenoxy 4-chlorophenyl 353 , 3-dimethylphenoxy 4-methyl-2-phenyl-l,2,3- 399 triazol-5-yl , 3-dimethylphenoxy benzo [b] thiophen-2-yl 374 , 3-dimethylphenoxy 3 , 4-dimethylphenyl 346 , 3 -dimethylphenoxy 2- (phenoxy) pyridin-3-yl 411 , 3-dimethylphenoxy 2- (methylthio)pyridin-3-yl 365 , 3-dimethylphenoxy 5-methyl-3-phenylisoxazol- 399 4-yl , 3-dimethylphenoxy 4-chloro-l,3-dimethyl 422 pyrazolo [3 , 4-b]pyridin-3- yi , 3-dimethylphenoxy 2-chloro-6-methylpyridin- 368 4-yl , 3-dimethylphenoxy 3 , 5-dimethylisoxazol-4-yl 337 , 3-dimethylphenoxy 1-naphthyl 368 , 3 -dimethylphenoxy 2-fluorophenyl 336 , 3-dimethylphenoxy 4-propylphenyl 360 , 3 -dimethylphenoxy 3-fluorophenyl 336 , 3-dimethylphenoxy 2 , 6-difluorophenyl 354 , 3-dimethylphenoxy 2-chlorophenyl 353 , 3-dimethylphenoxy 3 - ( chloromethyl ) phenyl 368 , 3-dimethylphenoxy 4- (2- (2-methyl) propyl ) 374 phenyl , 3-dimethylphenoxy 3-chlorophenyl 353 , 3-dimethylphenoxy 3 , 5-dimethoxyphenyl 378 , 3-dimethylphenoxy 2 , 6-dichlorophenyl 387 , 3-dimethylphenoxy 2 , 4-dichlorophenyl 387 , 3-dimethylphenoxy 4-fluorophenyl 336 , 3-dimethylphenoxy 4-butylphenyl 374 , 3-dimethylphenoxy 2-methylphenyl 332 , 3-dimethylphenoxy phenyl 318 , 3-dimethylphenoxy 4-ethyIphenyl 346 , 3-dimethylphenoxy 2 , 3 -difluorophenyl 354 , 3-dimethylphenoxy 2 , 6-dimethoxyphenyl 378 , 3-dimethylphenoxy 3 , 4-difluorophenyl 354 , 3-dimethylphenoxy 2 , 5-difluorophenyl 354 , 3-dimethylphenoxy 4-ethoxyphenyl 362 , 3-dimethylphenoxy 2,4, 6-trichlorophenyl 422 , 3-dimethylphenoxy 3 -methylphenyl 332 , 3-dimethylphenoxy 2-fluoro-5- 404 :trifluoromethyl ) phenyl , 3-dimethylphenoxy 3 -methoxyphenyl 348 , 3-dimethylphenoxy 2-bromophenyl 397 , 3-dimethylphenoxy 4-bromophenyl 397 , 3-dimethylphenoxy 4-fluoro-3- 404 ( trifluoromethyl ) phenyl , 3-dimethylphenoxy 3- (trifluoromethoxy) phenyl 402 , 3-dimethylphenoxy 9-fluorenon-4-yl 420 , 3-dimethylphenoxy isoxazol-5-yl 609 , 3-dimethylphenoxy benzofuroxan-5-y1 376 , 3-dimethylphenoxy 2-chloropyrid-3 -yl 354 , 3-dimethylphenoxy 2-(4- 425 methylphenoxy) pyridin-3-yl , 3-dimethylphenoxy pyridin-4-yl 319 , 3-dimethylphenoxy anthraquinon-2-yl 448 , 3-dimethylphenoxy 2-iodophenyl 444 , 3 -dimethylphenoxy 4-pentylpheny1 388 , 3-dimethylphenoxy 2- (4-chlorophenylthio) 462 pyridin-3-yl , 3-dimethylphenoxy 2 , 6-dimethylphenyl 346 , 3-dimethylphenoxy 2 , 5-dimethoxyphenyl 378 , 3-dimethylphenoxy 2 , 5-dichloropyridin-3-yl 388 , 3-dimethylphenoxy 2-chloro-6-methoxypyridin- 384 4-yl , 3-dimethylphenoxy 2 , 3-dichloropyridin-5-yl 388 , 3-dimethylphenoxy 1-naphthyl 382 , 3-dimethylphenoxy 2 , 4-dimethoxyphenyl 378 , 3-dimethylphenoxy 3 , 5-bis (trifluoromethyl) 454 phenyl 2 , 3-dimethylphenoxy 2-(4- 446 chlorophenoxy) pyridin-3-yl 2 , 3-dimethylphenoxy pentafluorophenyl 408 3,5-(bis-2- 3 , 4-dimethoxyphenyl 434 propyl) phenoxy 3,5-(bis-2- 2- (trifluoromethyl) phenyl 442 propyl)phenoxy 3,5-(bis-2- 2 , 4-difluorophenyl 410 propyl ) phenoxy 3,5-(bis-2- 3- (trifluoromethyl )phenyl 442 propyl ) phenoxy 3,5-(bis-2- 2-naphthyl 425 propyl ) phenoxy 3,5-(bis-2- 2-methoxyphenyl 404 propyl ) phenoxy 3,5-(bis-2- 3,4, 5-trimethylphenyl 465 propyl ) phenoxy 3,5-(bis-2- 3 , 4-dichlorophenyl 443 propyl ) phenoxy 3,5-(bis-2- 3-bromophenyl 453 propyl)phenoxy 3,5-(bis-2- 3-pyridyl 375 propyl)phenoxy 3,5-(bis-2- 2-ethoxynaphth-1-y1 469 propyl ) phenoxy 3,5-(bis-2- 2 , 3-dichlorophenyl 443 propyl )phenoxy 3,5-(bis-2- 6-chloropyrid-3-yl 410 propyl ) phenoxy 3,5-(bis-2- 4- (trifluoromethoxy) phenyl 458 propyl ) phenoxy 3,5-(bis-2- 2-fluoro-4- 460 propyl ) phenoxy ( trifluoromethyl ) phenyl 3,5-(bis-2- 3-bromothienyl 459 propyl ) phenoxy 3,5-(bis-2- 2-acetoxyphenyl 432 propyl ) phenoxy 3,5-(bis-2- 5-methylisoxazol-3-yl 379 propyl ) phenoxy 3,5-(bis-2- 2- (phenylthio) pyrid-3 -yl 484 propyl ) phenoxy 3,5-(bis-2- 2- (trifluoromethoxy) phenyl 458 propyl ) phenoxy 3,5-(bis-2- 1-phenyl-5-propylpyrazin- 483 propyl ) phenoxy 4-yl 3,5-(bis-2- 2-ethoxyphenyl 418 propyl ) phenoxy 3,5-(bis-2- 3-chlorothiophen-2-yl 415 propyl ) phenoxy 3,5-(bis-2- l-(2- (2-methyl) propyl) -3- 435 propyl ) phenoxy methylpyrazol-5-yl 3,5-(bis-2- 3 , 5-dichlorophenyl 443 propyl ) phenoxy 3,5-(bis-2- 2- (propylthio) pyridin-3-yl 450 propyl ) phenoxy 3,5-(bis-2- 2- (ethylthio) pyridin-3-yl 436 propyl ) phenoxy 3,5-(bis-2- 3-bromopyridin-5-yl 454 propyl ) phenoxy 3,5-(bis-2- 4-methyl-l, 2, 3-thiadiazol- 396 propyl ) phenoxy 5-yl 3,5-(bis-2- l-methyl-3-(2-(2- 435 propyl ) phenoxy methyl ) propyl ) pyrazol-5-yl 3, 5- (bis-2- 3-chlorobenzo[b] thiophen- 465 propyl ) phenoxy 2-yl 3,5-(bis-2- 4-chlorophenyl 409 propyl ) phenoxy 3,5- (bis-2- 4-methyl-2-phenyl-l,2,3- 456 propyl ) phenoxy triazol-5-yl 3,5-(bis-2- benzo [b] thiophen-2-yl 431 propyl ) phenoxy 3,5-(bis-2- 3 , 4-dimethylphenyl 402 propyl) phenoxy 3,5- (bis-2- 2- (phenoxy) pyridin-3-yl 468 propyl ) phenoxy 3,5-(bis-2- 2- (methylthio)pyridin-3-yl 422 propyl ) phenoxy 3,5-(bis-2- 5-methyl-3-phenylisoxazol- 456 propyl ) phenoxy 4-yl 3,5-(bis-2- 4-chloro-l, 3-dimethyl 478 propyl ) phenoxy pyrazolo [3, 4-b]pyridin-3- yi 3,5-(bis-2- 2-chloro-6-methylpyridin- 424 propyl ) phenoxy 4-yl 3,5-(bis-2- 3 , 5-dimethylisoxazol-4-yl 393 propyl ) phenoxy 3,5-(bis-2- 1-naphthyl 425 propyl ) phenoxy 3,5-(bis-2- 2-fluorophenyl 392 propyl ) phenoxy 3,5-(bis-2- 4-propyIphenyl 417 propyl ) phenoxy 3,5-(bis-2- 3-fluorophenyl 392 propyl ) phenoxy 3 , 5- (bis-2- 2 , 6-difluorophenyl 410 propyl ) phenoxy 3,5-(bis-2- 2-chlorophenyl 409 propyl ) phenoxy 3,5-(bis-2- 3- ( chloromethyl ) phenyl 423 propyl ) phenoxy 3,5-(bis-2- 4- ( 2- (2-methyl ) propyl ) 431 propyl ) phenoxy phenyl 3,5-(bis-2- 3-chlorophenyl 409 propyl ) phenoxy 3,5-(bis-2- 3 , 5-dimethoxyphenyl 434 propyl ) phenoxy 3,5-(bis-2- 2 , 6-dichlorophenyl 443 propyl ) phenoxy 3,5-(bis-2- 2 , 4-dichlorophenyl 443 propyl ) phenoxy 3,5-(bis-2- 4-fluorophenyl 392 propyl ) phenoxy 3,5-(bis-2- 4-butylpheny1 431 propyl ) phenoxy 3,5-(bis-2- 2-methylphenyl 388 propyl ) phenoxy 3,5-(bis-2- phenyl 374 propyl) phenoxy 3,5-(bis-2- 4-ethyIphenyl 402 propyl ) phenoxy 3,5-(bis-2- 2 , 3-difluorophenyl 410 propyl ) phenoxy 3,5-(bis-2- 2 , 6-dimethoxyphenyl 434 propyl ) phenoxy 3,5-(bis-2- 3 , 4-difluorophenyl 410 propyl ) phenoxy 3, 5- (bis-2- 2 , 5-difluorophenyl 410 propyl ) phenoxy 3,5-(bis-2- 4-ethoxyphenyl 418 propyl ) phenoxy 3,5-(bis-2- 2,4, 6-trichlorophenyl 478 propyl ) phenoxy 3,5-(bis-2- 3-methylphenyl 388 propyl ) phenoxy 3, 5- (bis-2- 2-fluoro-5- 460 propyl ) phenoxy ( trifluoromethyl) phenyl 3,5-(bis-2- 3-methoxyphenyl 404 propyl ) phenoxy 3, 5- (bis-2- 2-bromophenyl 453 propyl ) phenoxy 3,5-(bis-2- 4-bromophenyl 453 propyl)phenoxy 3,5- (bis-2- 4-fluoro-3- 460 propyl ) phenoxy ( trifluoromethyl ) phenyl 3,5-(bis-2- 3- (trifluoromethoxy) phenyl 458 propyl ) phenoxy 3,5-(bis-2- 9-fluorenon-4-yl 477 propyl ) phenoxy 3,5-(bis-2- isoxazol-5-yl 365 propyl )phenoxy 3,5-(bis-2- benzofuroxan-5-yl 432 propyl ) phenoxy 3,5- (bis-2- 2-chloropyrid-3-yl 410 propyl ) henoxy 3,5-(bis-2- 2-(4- 482 propyl ) phenoxy methylphenoxy) pyridin-3 -yl 3,5- (bis-2- pyridin-4-yl 375 propyl ) phenoxy 3,5-(bis-2- anthraquinon-2-yl 505 propyl ) phenoxy 3,5-(bis-2- 2-iodophenyl 500 propyl ) phenoxy 3,5-(bis-2- 4-pentyIphenyl 445 propyl ) phenoxy 3,5-(bis-2- 2-(4-chlorophenylthio) 518 propyl ) phenoxy pyridin-3-yl 3,5-(bis-2- 2 , 6-dimethylphenyl 402 propyl ) phenoxy 3,5-(bis-2- 2 , 5-dimethoxyphenyl 434 propyl ) phenoxy 3,5-(bis-2- 2, 5-dichloropyridin-3-yl 444 propyl ) phenoxy 3,5-(bis-2- 2-chloro-6-methoxypyridin- 440 propyl ) phenoxy 4-yl 3,5-(bis-2- 2,3-dichloropyridin-5-yl 444 propyl ) phenoxy 3,5-(bis-2- 1-naphthyl 439 propyl ) phenoxy 3,5-(bis-2- 2 , 4-dimethoxyphenyl 434 propyl ) phenoxy 3,5- (bis-2- 3 , 5-bis (trifluoromethyl) 510 propyl ) phenoxy phenyl 3,5-(bis-2- 2-(4- 502 propyl ) phenoxy chlorophenoxy) pyridin-3 -yl 3, 5- (bis-2- pentafluorophenyl 464 propyl ) henoxy 3 -trifluoromethyl 3 , 4-dimethoxyphenyl 418 phenoxy 3 -trifluoromethyl 2- (trifluoromethyl) phenyl 426 phenoxy 3-trifluoromethyl 2 , 4-difluorophenyl 394 phenoxy 3 -trifluoromethyl 3- (trifluoromethyl) phenyl 426 phenoxy 3-trifluoromethyl 2-naphthyl 408 phenoxy 3 -trifluoromethyl 2-methoxyphenyl 388 phenoxy 3-trifluoromethyl 3,4, 5-trimethylphenyl 448 phenoxy 3 -trifluoromethyl 3 , 4-dichlorophenyl 427 phenoxy 3-trifluoromethyl 3-bromophenyl 437 phenoxy 3-1rifluoromethyl 3 -pyridyl 359 phenoxy 3-trifluoromethyl 2-ethoxynaphth-1-y1 452 phenoxy 3 -trifluoromethyl 2 , 3-dichlorophenyl 427 phenoxy 3-trifluoromethyl 6-chloropyrid-3-yl 394 phenoxy 3 -trifluoromethyl 4- (trifluoromethoxy) phenyl 442 phenoxy 3 -trifluoromethyl 2-fluoro-4- 444 phenoxy ( trifluoromethyl ) phenyl 3 -trifluoromethyl 3-bromothienyl 443 phenoxy 3 -trifluoromethyl 2-acetoxyphenyl 416 phenoxy 3 -trifluoromethyl 5-methylisoxazol-3-yl 363 phenoxy 3 -trifluoromethyl 2- (phenylthio) pyrid-3-yl 467 phenoxy 3 -trifluoromethyl 2- (trifluoromethoxy) phenyl 442 phenoxy 3-trifluoromethyl l-phenyl-5-propylpyrazin- 466 phenoxy 4-yl 3-trifluoromethyl 2-ethoxyphenyl 402 phenoxy 3-trifluorome£hyl 3-chlorothien-2-yl 399 phenoxy 3-trifluoromethyl l-(2-(2-methyl)propyl)-3- 418 phenoxy methylpyrazol-5-yl 3 -trifluoromethyl 3 , 5-dichlorophenyl 427 phenoxy 3-trifluoromethyl 2- (propylthio) pyridin-3-yl 433 phenoxy 3-trifluoromethyl 2- (ethylthio) pyridin-3 -yl 419 phenoxy 3-trifluoromethyl 3-bromopyridin-5-yl 438 phenoxy 3-trifluoromethyl 4-methyl-l, 2, 3-thiadiazol- 380 phenoxy 5-yl 3 -trifluoromethyl l-methyl-3-(2- (2- 418 phenoxy methyl ) propyl ) pyrazol-5-yl 3 -trifluoromethyl 3-chlorobenzo[b] thiophen- 449 phenoxy 2-yl 3 -trifluoromethyl 4-chlorophenyl 393 phenoxy 3 -trifluoromethyl 4-methyl-2-phenyl-l,2,3- 439 phenoxy triazol-5-yl 3 -trifluoromethyl benzo [b] thiophen-2-yl 414 phenoxy 3 -trifluoromethyl 3 , 4-dimethylphenyl 386 phenoxy 3 -trifluoromethyl 2- (phenoxy) pyridin-3 -yl 451 phenoxy 3 -trifluoromethyl 2- (methylthio) pyridin-3-yl 405 phenoxy 3 -tri fluoromethyl 5-methyl-3-phenylisoxazol- 439 phenoxy 4-yl 3 -trifluoromethyl 4-chloro- 1,3 -dimethyl 462 phenoxy pyrazolo [3 , 4-b]pyridin-3- yi 3 -trifluoromethyl 2-chloro-6-methylpyridin- 408 phenoxy 4-yl 3 -trifluoromethyl 3 , 5-dimethylisoxazol-4-yl 377 phenoxy 3 -trifluoromethyl 1-naphthyl 408 phenoxy 3 -trifluoromethyl 2 -fluorophenyl 476 phenoxy 3 -trifluoromethyl 4-propyIphenyl 400 phenoxy 3 -trifluoromethyl 3 -fluorophenyl 376 phenoxy 3 -trifluoromethyl 2 , 6-difluorophenyl 394 phenoxy 3 -trifluoromethyl 2-chlorophenyl 393 phenoxy 3 -trifluoromethyl 3 - ( chloromethyl ) phenyl 407 phenoxy 3 -trifluoromethyl 4- ( 2- ( 2-methyl ) propyl ) 414 phenoxy phenyl 3-trifluoromethyl 3-chlorophenyl 393 phenoxy 3-trifluoromethyl 3 , 5-dimethoxyphenyl 418 phenoxy 3-trifluoromethyl 2 , 6-dichlorophenyl 427 phenoxy 3-trifluoromethyl 2 , 4-dichlorophenyl 427 phenoxy 3-trifluoromethyl 4-fluorophenyl 376 phenoxy 3-trifluoromethyl 4-butyIphenyl 414 phenoxy 3-trifluoromethyl 2-methylphenyl 372 phenoxy 3-trifluoromethyl phenyl 358 phenoxy 3 -trifluoromethyl 4-ethylphenyl 386 phenoxy 3-trifluoromethyl 2 , 3-difluorophenyl 394 phenoxy 3-trifluoromethyl 2 , 6-dimethoxyphenyl 418 phenoxy 3 -trifluoromethyl 3 , 4-difluorophenyl 394 phenoxy 3 -trifluoromethyl 2 , 5-difluorophenyl 394 phenoxy 3 -trifluoromethyl 4-ethoxyphenyl 402 phenoxy 3 -trifluoromethyl 2,4, 6-trichlorophenyl 462 phenoxy 3 -trifluoromethyl 3 -methylphenyl 372 phenoxy 3 -trifluoromethyl 2-fluoro-5- 444 phenoxy ( trifluoromethyl ) phenyl 3 -trifluoromethyl 3 -methoxyphenyl 388 phenoxy 3-trifluoromethyl 2-bromophenyl 437 phenoxy 3-trifluoromethyl 4-bromophenyl 437 phenoxy 3-trifluoromethyl 4-fluoro-3- 444 phenoxy ( trifluoromethyl ) phenyl 3 -trifluoromethyl 3- (trifluoromethoxy) phenyl 442 phenoxy 3-trifluoromethyl 9-fluorenon-4-yl 460 phenoxy 3 -trifluoromethyl isoxazol-5-yl 349 phenoxy 3 -trifluoromethyl benzofuroxan-5-yl 416 phenoxy 3 -trifluoromethyl 2-chloropyrid-3-yl 394 phenoxy 3-trifluoromethyl 2-(4- 465 phenoxy methylphenoxy) pyridin-3-yl 3-trifluoromethyl pyridin-4-yl 359 phenoxy 3-trifluoromethyl anthraquinon-2-yl 488 phenoxy 3-trifluoromethyl 2-iodophenyl 484 phenoxy 3-trifluoromethyl 4-pentyIphenyl 428 phenoxy 3- rifluoromethyl 2- (4-chlorophenylthio) 502 phenoxy pyridin-3-yl 3-trifluoromethyl 2,6-dimethylphenyl 386 phenoxy 3-trifluoromethyl 2 , 5-dimethoxyphenyl 418 phenoxy 3-trifluoromethyl 2, 5-dichloropyridin-3-yl 428 phenoxy 3-trifluoromethyl 2-chloro-6-methoxypyridin- 424 phenoxy 4-yl 3-trifluo omethyl 2, 3-dichloropyridin-5-yl 428 phenoxy 3-trifluoromethyl 1-naphthyl 422 phenoxy 3-trifluoromethyl 2 , 4-dimethoxyphenyl 418 phenoxy 3-trifluoromethyl 3,5- 494 phenoxy bis (trifluoromethyl ) phenyl 3-trifluoromethyl 2-(4- 486 phenoxy chlorophenoxy)pyridin-3-y1 3-trifluoromethyl pentafluorophenyl 448 phenoxy 2 , 6-dichlorophenoxy 3 , 4-dimethoxyphenyl 419 ,6- dichlorophenoxy 2 - (trifluoromethyl) henyl 427 ,6- dichlorophenoxy 2 , 4 -difluorophenyl 395 ,6- dichlorophenoxy 3 - (trifluoromethyl) phenyl 427 ,6- dichlorophenoxy 2 -naphthyl 409 ,6- dichlorophenoxy 2 -methoxyphenyl 389 ,6- dichlorophenoxy 3,4,5-trimethylphenyl 449 ,6- dichlorophenoxy 3, 4 -dichlorophenyl 428 ,6- dichlorophenoxy 3 -bromophenyl 438 , 6 -dichlorophenoxy 3-pyridyl 361 ,6- dichlorophenoxy 2 -ethoxynaphth- 1-yl 453 ,6- dichlorophenoxy 2 , 3 -dichlorophenyl 428 ,6- dichlorophenoxy 6 -chloropyrid- 3 -yl 395 ,6- dichlorophenoxy 4 - (trifluoromethoxy) henyl 443 ,6- dichlorophenoxy 2-fluoro-4- 445 (trifluoromethyl) henyl ,6- dichlorophenoxy 3 -bromothienyl 444 ,6- dichlorophenoxy 2 -acetoxyphenyl 417 ,6- dichlorophenoxy 5 -methylisoxazol - 3 -yl 364 ,6- dichlorophenoxy 2- (phenylthio)pyrid-3-yl 468 ,6- dichlorophenoxy 2 - (trifluoromethoxy) phenyl 443 ,6- dichlorophenoxy 1 -phenyl- 5 -propylpyrazin- 467 4-yl ,6- dichlorophenoxy 2 - ethoxyphenyl 403 ,6- dichlorophenoxy 3-chlorothien-2-yl 400 ,6- dichlorophenoxy 1- (2- (2 -methyl) propyl) -3- 419 methylpyrazol -5-yl ,6- dichlorophenoxy 3 , 5 -dichlorophenyl 428 ,6- dichlorophenoxy 2 - (propylthio) yridin- 3 -yl 434 , 6-dichlorophenoxy 2-(ethylthio)pyridin-3-yl 420 , 6-dichlorophenoxy 3-bromopyridin-5-yl 439 , 6 -dichlorophenoxy 4-methyl-l, 2, 3-thiadiazol- 381 5-yl , 6-dichlorophenoxy l-methyl-3-(2-(2- 419 methyl ) propyl ) pyrazol- 5-yl , 6-dichlorophenoxy 3 -chlorobenzo [b] thiophen- 450 2-yl , 6-dichlorophenoxy 4-chlorophenyl 394 , 6-dichlorophenoxy 4-methyl-2-phenyl-l,2,3- 440 triazol-5-yl , 6-dichlorophenoxy benzo [b] thiophen-2-yl 415 , 6-dichlorophenoxy 3, 4-dimethyIphenyl 387 , 6-dichlorophenoxy 2- (phenoxy) pyridin-3-yl 452 , 6-dichlorophenoxy 2- (methylthio) pyridin-3-yl 406 , 6-dichlorophenoxy 5-methyl-3-phenylisoxazol- 440 4-yl , 6-dichlorophenoxy 4-chloro-l, 3 -dimethyl 463 pyrazolo [3 , 4-b]pyridin-3- yi , 6-dichlorophenoxy 2-chloro-6-methylpyridin- 409 4-yl , 6-dichlorophenoxy 3 , 5-dimethylisoxazol-4-yl 378 , 6-dichlorophenoxy 1-naphthyl 409 , 6-dichlorophenoxy 2- fluorophenyl 377 , 6-dichlorophenoxy 4-propylpheny1 401 , 6-dichlorophenoxy 3-fluorophenyl 377 , 6-dichlorophenoxy 2, 6-difluorophenyl 395 , 6-dichlorophenoxy 2 -chlorophenyl 394 , 6-dichlorophenoxy 3- (chloromethyl) phenyl 408 , 6-dichlorophenoxy 4- ( 2- ( 2-methyl ) propyl ) 415 phenyl , 6-dichlorophenoxy 3 -chlorophenyl 694 , 6-dichlorophenoxy 3 , 5-dimethoxyphenyl 419 , 6-dichlorophenoxy 2 , 6-dichlorophenyl 428 , 6-dichlorophenoxy 2 , 4-dichlorophenyl 428 , 6-dichlorophenoxy 4-fluorophenyl 377 , 6-dichlorophenoxy 4-butyIphenyl 415 , 6-dichlorophenoxy 2-methylphenyl 373 , 6-dichlorophenoxy phenyl 359 , 6-dichlorophenoxy 4-ethyIphenyl 387 , 6-dichlorophenoxy 2 , 3 -difluorophenyl 395 , 6-dichlorophenoxy 2 , 6-dimethoxyphenyl 419 , 6-dichlorophenoxy 3 , 4-difluorophenyl 395 2, 6-dichlorophenoxy 2 , 5-difluorophenyl 395 2, 6-dichlorophenoxy 4-ethoxyphenyl 403 2, , 6-dichlorophenoxy 2,4, 6-trichlorophenyl 463 2, , 6-dichlorophenoxy 3 -methylphenyl 373 2, , 6-dichlorophenoxy 2-fluoro-5- 445 ( trifluoromethyl ) phenyl 2, , 6-dichlorophenoxy 3-methoxyphenyl 389 2, , 6-dichlorophenoxy 2-bromophenyl 438 2. , 6-dichlorophenoxy 4-bromophenyl 438 2 , 6-dichlorophenoxy 4-fluoro-3- 445 ( trifluoromethyl ) phenyl 2 , 6-dichlorophenoxy 3- (trifluoromethoxy) phenyl 443 2 , 6-dichlorophenoxy 9-fluorenon-4-yl 461 2 , 6-dichlorophenoxy isoxazol-5-yl 350 , 6-dichlorophenoxy benzofuroxan-5-y1 417 , 6-dichlorophenoxy 2-chloropyrid-3-yl 395 , 6 -dichlorophenoxy 2-(4- 466 methylphenoxy) pyridin- -3-yl , 6-dichlorophenoxy pyridin-4-yl 360 , 6-dichlorophenoxy anthraquinon-2-y1 489 , 6-dichlorophenoxy 2-iodophenyl 485 , 6-dichlorophenoxy 4-pentyIphenyl 429 , 6-dichlorophenoxy 2- (4-chlorophenylthio) 1 503 pyridin-3-yl , 6-dichlorophenoxy 2 , 6-dimethylphenyl 387 , 6 -dichlorophenoxy 2 , 5-dimethoxyphenyl 419 , 6-dichlorophenoxy 2, 5-dichloropyridin-3- -yl 429 , 6-dichlorophenoxy 2-chloro-6-methoxypyridin- 425 4-yl , 6-dichlorophenoxy 2 , 3-dichloropyridin-5- -yl 429 , 6-dichlorophenoxy 1-naphthyl 413 , 6-dichlorophenoxy 2 , 4-dimethoxyphenyl 419 , 6-dichlorophenoxy 3,5- 495 bis (trifluoromethyl) phenyl , 6-dichlorophenoxy 2-(4- 487 chlorophenoxy) pyridin-3-yl , 6-dichlorophenoxy pentafluorophenyl 449 , 4-dichlorophenoxy 3 , 4-dimethoxyphenyl 419 , 4-dichlorophenoxy 2- (trifluoromethyl) phenyl 427 , 4-dichlorophenoxy 2, 4-difluorophenyl 395 , 4-dichlorophenoxy 3- (trifluoromethyl) phenyl 427 , 4-dichlorophenoxy 2 -naphthyl 409 , 4-dichlorophenoxy 2 -methoxyphenyl 389 , 4-dichlorophenoxy 3 , 4, 5-trimethylphenyl 449 , 4-dichlorophenoxy 3, 4-dichlorophenyl 428 , 4-dichlorophenoxy 3 -bromophenyl 438 , 4-dichlorophenoxy 3-pyridyl 361 , 4-dichlorophenoxy 2-ethoxynaphth-l-yl 453 , 4-dichlorophenoxy 2, 3-dichlorophenyl 428 , 4-dichlorophenoxy 6-chloropyrid-3-yl 395 , 4-dichlorophenoxy 4- (trifluoromethoxy) phenyl 443 , 4-dichlorophenoxy 2-fluoro-4- 445 (trifluoromethyl ) phenyl , 4-dichlorophenoxy 3-bromothienyl 444 , 4-dichlorophenoxy 2-acetoxyphenyl 417 , 4-dichlorophenoxy 5-methylisoxazol-3-yl 364 , 4-dichlorophenoxy 2- (phenylthio)ρyrid-3-yl 468 , 4-dichlorophenoxy 2- (trifluoromethoxy) phenyl 443 , 4-dichlorophenoxy 1-phenyl-5-propylpyrazin- 467 4-yl , 4-dichlorophenoxy 2-ethoxyphenyl 403 , -dichlorophenoxy 3-chlorothien-2-yl 400 , 4-dichlorophenoxy l-(2-(2-methyl)propyl)-3- 419 methylpyrazol-5-yl , 4-dichlorophenoxy 3 , 5-dichlorophenyl 428 , 4-dichlorophenoxy 2- (propylthio) pyridin-3-yl 434 , 4-dichlorophenoxy 2-(ethylthio)pyridin-3-yl 420 , 4-dichlorophenoxy 3-bromopyridin-5-yl 439 , 4-dichlorophenoxy 4-methyl-l, 2, 3-thiadiazol- 381 5-yl , 4-dichlorophenoxy l-methyl-3-(2-(2- 419 methyl ) propyl ) pyrazol-5-yl , 4-dichlorophenoxy 3-chlorobenzo[b] thiophen- 450 2-yl , 4-dichlorophenoxy 4-chlorophenyl 394 , 4-dichlorophenoxy 4-methyl-2 -phenyl-1,2, 3- 440 triazol-5-yl , 4-dichlorophenoxy benzo [b] thiophen-2-yl 415 , 4-dichlorophenoxy 3, 4-dimethyIphenyl 387 , 4-dichlorophenoxy 2- (phenoxy) pyridin-3-yl 452 , 4-dichlorophenoxy 2- (methylthio) pyridin-3-yl 406 , 4 -dichlorophenoxy 5-methyl-3-phenylisoxazol- 440 4-yl , 4-dichlorophenoxy 4-chloro-l, 3-dimethyl 463 pyrazolo [3 , 4-b]pyridin-3- yi , 4-dichlorophenoxy 2 -chloro-6-methylpyridin- 409 4-yl , 4-dichlorophenoxy 3 , 5-dimethylisoxazol-4-yl 378 , 4 -dichlorophenoxy 1-naphthyl 409 , 4-dichlorophenoxy 2 -fluorophenyl 377 , 4 -dichlorophenoxy 4-propyIphenyl 401 , 4-dichlorophenoxy 3 -fluorophenyl 377 , 4-dichlorophenoxy 2, 6-difluorophenyl 395 , 4-dichlorophenoxy 2-chlorophenyl 394 , 4-dichlorophenoxy 3- (chloromethyl) phenyl 408 , 4-dichlorophenoxy 4-(2-(2- 415 methyl ) propyl ) phenyl , 4-dichlorophenoxy 3 -chlorophenyl 694 , 4-dichlorophenoxy 3,5-dimethoxyphenyl 419 , 4-dichlorophenoxy 2 , 6-dichlorophenyl 428 , 4-dichlorophenoxy 2 , 4-dichlorophenyl 428 , 4-dichlorophenoxy 4-fluorophenyl 377 , 4-dichlorophenoxy 4-butyIphenyl 415 , 4-dichlorophenoxy 2-methylphenyl 373 , 4-dichlorophenoxy phenyl 359 , 4-dichlorophenoxy 4-ethyIphenyl 387 , 4-dichlorophenoxy 2 , 3-difluorophenyl 395 , 4-dichlorophenoxy 2 , 6-dimethoxyphenyl 419 , 4-dichlorophenoxy 3 , 4-difluorophenyl 395 , 4-dichlorophenoxy 2 , 5-difluorophenyl 395 4-dichlorophenoxy 4-ethoxyphenyl 403 , 4-dichlorophenoxy 2,4, 6-trichlorophenyl 463 4-dichlorophenoxy 3 -methylphenyl 373 4-dichlorophenoxy 2-fluoro-5- 445 ( trifluoromethyl ) phenyl 4-dichlorophenoxy 3-methoxyphenyl 389 4-dichlorophenoxy 2-bromophenyl 438 4-dichlorophenoxy 4-bromophenyl 438 4-dichlorophenoxy 4-fluoro-3- 445 ( trifluoromethyl ) phenyl , 4-dichlorophenoxy 3- (trifluoromethoxy) phenyl 443 , 4-dichlorophenoxy 9-fluorenon-4-yl 461 , 4-dichlorophenoxy isoxazol-5-yl 350 , 4-dichlorophenoxy benzofuroxan-5-yl 417 , 4-dichlorophenoxy 2 -chloropyrid-3 -yl 395 , 4-dichlorophenoxy 2-(4- 466 methylphenoxy)pyridin-3-yl , 4-dichlorophenoxy pyridin-4-yl 360 2 , 4-dichlorophenoxy anthraquinon-2-yl 489 2 , 4-dichlorophenoxy 2-iodophenyl 485 2 , 4-dichlorophenoxy 4-pentyIphenyl 429 2 , 4-dichlorophenoxy 2- (4-chlorophenylthio) 503 pyridin-3-yl 2 , 4-dichlorophenoxy 2 , 6-dimethylphenyl 387 2 , 4-dichlorophenoxy 2 , 5-dimethoxyphenyl 419 2 , 4-dichlorophenoxy 2, 5-dichloropyridin-3-yl 429 2 , 4-dichlorophenoxy 2-chloro-6-methoxypyridin- 425 4-yl 2 , 4-dichlorophenoxy 2 , 3-dichloropyridin-5-yl 429 2 , 4-dichlorophenoxy 1-naphthyl 413 2 , 4-dichlorophenoxy 2 , 4-dimethoxyphenyl 419 2 , 4-dichlorophenoxy 3,5- 495 bis (trifluoromethyl) phenyl 2 , 4-dichlorophenoxy 2-(4- 487 chlorophenoxy) pyridin-3-y1 2 , 4-dichlorophenoxy pentafluorophenyl 449 4-chloro-3- 3 , 4-dimethoxyphenyl 319 methylphenoxy 4-chloro-3- 2- (trifluoromethyl)phenyl 407 methylphenoxy 4-chloro-3- 2 , 4-difluorophenyl 375 methylphenoxy 4-chloro-3- 3- (trifluoromethyl) phenyl 407 methylphenoxy 4-chloro-3- 2-naphthyl 389 methylphenoxy 4-chloro-3- 2-methoxyphenyl 369 methylphenoxy 4-chloro-3- 3,4, 5-trimethyIphenyl 429 methylphenoxy 4-chloro-3- 3 , 4-dichlorophenyl 408 methylphenoxy 4-chloro-3- 3 -bromophenyl 418 methylphenoxy 4-chloro-3- 3-pyridyl 340 methylphenoxy 4-chloro-3- 2-ethoxynaphth-l-yl 433 methylphenoxy 4-chloro-3- 2 , 3 -dichlorophenyl 408 methylphenoxy 4-chloro-3- 6-chloropyrid-3-yl 374 methylphenoxy 4-chloro-3- 4- (trifluoromethoxy) phenyl 423 methylphenoxy 4-chloro-3- 2-fluoro-4- 425 methylphenoxy ( trifluoromethyl ) phenyl 4-chloro-3- 3-bromothienyl 424 methylphenoxy 4-chloro-3- 2-acetoxyphenyl 397 methylphenoxy 4-chloro-3- 5-methylisoxazol-3-yl 344 methylphenoxy 4-chloro-3- 2-(phenylthio)pyrid-3-yl 448 methylphenoxy 4-chloro-3- 2- (trifluoromethoxy) phenyl 423 methylphenoxy 4-chloro-3- l-phenyl-5-propylpyrazin- 447 methylphenoxy 4-yl 4-chloro-3- 2-ethoxyphenyl 383 methylphenoxy 4-chloro-3- 3-chlorothien-2-yl 379 methylphenoxy 4-chloro-3- l-(2-(2-methyl)propyl)-3- 399 methylphenoxy methylpyrazol-5-yl 4-chloro-3- 3 , 5-dichlorophenyl 408 methylphenoxy 4-chloro-3- 2- (propylthio) pyridin-3-yl 414 methylphenoxy 4-chloro-3- 2-(ethylthio)pyridin-3-yl 400 methylphenoxy 4-chloro-3- 3-bromopyridin-5-yl 419 methylphenoxy 4-chloro-3- 4-methyl-l, 2, 3 -thiadiazol- 361 methylphenoxy 5-yl 4-chloro-3- l-methyl-3-(2-(2- 399 methylphenoxy methyl ) propyl ) pyrazol-5-yl 4-chloro-3- 3 -chlorobenzo [b] thiophen- 429 methylphenoxy 2-yl 4-chloro-3- 4-chlorophenyl 373 methylphenoxy 4-chloro-3- 4-methyl-2-phenyl-l,2,3- 420 methylphenoxy triazol-5-yl 4-chloro-3- benzo [b] thiophen-2-yl 395 methylphenoxy 4-chloro-3- 3 , 4-dimethyIphenyl 367 methylphenoxy 4-chloro-3- 2- (phenoxy) pyridin-3-yl 432 methylphenoxy 4-chloro-3- 2- (methylthio)pyridin-3-yl 386 ethylphenoxy 4-chloro-3- 5-methyl-3 -phenylisoxazol- 420 methylphenoxy 4-yl 4-chloro-3- 4-chloro-l, 3-dimethyl 442 methylphenoxy pyrazolo [3 , 4-b]pyridin-3- yi 4-chloro-3- 2-chloro-6-methylpyridin- 388 methylphenoxy 4-yl 4-chloro-3- 3 , 5-dimethylisoxazol-4-yl 358 methylphenoxy 4-chloro-3- 1-naphthyl 389 methylphenoxy 4-chloro-3- 2-fluorophenyl 357 methylphenoxy 4-chloro-3- 4-propylphenyl 381 methylphenoxy 4-chloro-3- 4- (trifluoromethyl) phenyl 407 methylphenoxy 4-chloro-3- 3-fluorophenyl 357 methylphenoxy 4-chloro-3- 2 , 6-difluorophenyl 375 methylphenoxy 4-chloro-3- 2-chlorophenyl 373 methylphenoxy 4-chloro-3- 3- (chloromethyl ) phenyl 387 methylphenoxy 4-chloro-3- 4-(2-(2- 395 methylphenoxy methyl ) propyl ) phenyl 4-chloro-3- 3-chlorophenyl 373 methylphenoxy 4-chloro-3- 3 , 5-dimethoxyphenyl 399 methylphenoxy 4-chloro-3- 2 , 6-dichlorophenyl 408 methylphenoxy 4-chloro-3- 2 , 4-dichlorophenyl 408 methylphenoxy 4-chloro-3- 4-fluorophenyl 357 methylphenoxy 4-chloro-3- 4-butyIphenyl 395 methylphenoxy 4-chloro-3- 2-methylphenyl 353 methylphenoxy 4-chloro-3- phenyl 339 methylphenoxy 4-chloro-3- 4-ethyIphenyl 367 methylphenoxy 4-chloro-3- 2 , 3-difluorophenyl 375 methylphenoxy 4-chloro-3- 2 , 6-dimethoxyphenyl 399 methylphenoxy 4-chloro-3- 3 , 4-difluorophenyl 375 methylphenoxy 4-chloro-3- 2 , 5-difluorophenyl 375 methylphenoxy 4-chloro-3- 4-ethoxyphenyl 383 methylphenoxy 4-chloro-3- 2,4, 6-trichlorophenyl 442 methylphenoxy 4-chloro-3- 3-methylphenyl 353 methylphenoxy 4-chloro-3- 2-fluoro-5- 425 methylphenoxy ( trifluoromethyl ) phenyl 4-chloro-3- 3 -methoxyphenyl 369 methylphenoxy 4-chloro-3- 2-bromophenyl 418 methylphenoxy 4-chloro-3- 4-bromophenyl 418 methylphenoxy 4-chloro-3- 4-fluoro-3- 425 methylphenoxy ( trifluoromethyl ) phenyl 4-chloro-3- 3- (trifluoromethoxy) phenyl 423 methylphenoxy 4-chloro-3- 9-fluorenon-4-y1 441 methylphenoxy 4-chloro-3- isoxazol-5-yl 330 methylphenoxy 4-chloro-3- benzofuroxan-5-yl 397 methylphenoxy 4-chloro-3- 2-chloropyrid-3-yl 374 methylphenoxy 4-chloro-3- 2-(4- 446 methylphenoxy methylphenoxy) pyridin-3-yl 4-chloro-3- pyridin-4-yl 340 methylphenoxy 4-chloro-3- anthraquinon-2-y1 469 methylphenoxy 4-chloro-3- 2-iodophenyl 465 methylphenoxy 4-chloro-3- 4-pentyIphenyl 409 methylphenoxy 4-chloro-3- 2- (4-chlorophenylthio) 482 methylphenoxy pyridin-3-yl 4-chloro-3- 2 , 6-dimethylphenyl 367 methylphenoxy 4-chloro-3- 2 , 5-dimethoxyphenyl 399 methylphenoxy 4-chloro-3- 2, 5-dichloropyridin-3-yl 409 methylphenoxy 4-chloro-3- 2-chloro-6-methoxypyridin- 404 methylphenoxy 4-yl 4-chloro-3- 2, 3-dichloropyridin-5-yl 409 methylphenoxy 4-chloro-3- 1-naphthyl 403 methylphenoxy 4-chloro-3- 2 , 4-dimethoxyphenyl 399 methylphenoxy 4-chloro-3- 3,5- 475 ethylphenoxy bis (trifluoromethyl) phenyl 4-chloro-3- 2-(4- 466 methylphenoxy chlorophenoxy) pyridin-3-yl 4-chloro-3- pentafluorophenyl 429 methylphenoxy 4-chloro-2- 3 , 4-dimethoxyphenyl 467 cyc1ohexylphenoxy 4-chloro-2- 2- (trifluoromethyl) phenyl 475 cyc1ohexylphenoxy 4-chloro-2- 2 , 4-difluorophenyl 443 cyclohexylphenoxy 4-chloro-2- 3- (trifluoromethyl) phenyl 475 cyc1ohexylphenoxy 4-chloro-2- 2-naphthyl 457 cyc1ohexylphenoxy 4-chloro-2- 2-methoxyphenyl 437 cyc1ohexylphenoxy 4-chloro-2- 3,4, 5-trimethylphenyl 497 cyc1ohexylphenoxy 4-chloro-2- 3 , 4-dichlorophenyl 176 cyc1ohexylphenoxy 4-chloro-2- 3 -bromophenyl 486 cyc1ohexylphenoxy 4-chloro-2- 3-pyridyl 408 cyc1ohexylphenoxy 4-chloro-2- 2-ethoxynaphth-l-yl 501 cyclohexylphenoxy 4-chloro-2- 2 , 3 -dichlorophenyl 476 cyc1ohexylphenoxy 4-chloro-2- 6-chloropyrid-3-yl 442 cyc1ohexylphenoxy 4-chloro-2- 4- (trifluoromethoxy) phenyl 491 cyc1ohexylphenoxy 4-chloro-2- 2-fluoro-4- 493 cyc1ohexylphenoxy ( trifluoromethyl ) phenyl 4-chloro-2- 3-bromothienyl 492 cyc1ohexylphenoxy 4-chloro-2- 2-acetoxyphenyl 465 cyc1ohexylphenoxy 4-chloro-2- 5-methylisoxazol-3-yl 412 cyc1ohexylphenoxy 4-chloro-2- 2- (phenylthio) pyrid-3-yl 516 cyc1ohexylphenoxy 4-chloro-2- 2- (trifluoromethoxy) phenyl 491 cyc1ohexylphenoxy 4-chloro-2- 1-phenyl-5-propylpyrazin- 515 cyc1ohexylphenoxy 4-yl 4-chloro-2- 2-ethoxyphenyl 451 cyc1ohexylphenoxy 4-chloro-2- 3-chlorothien-2-yl 447 cyclohexylphenoxy 4-chloro-2- l-(2- (2-methyl)propyl) -3- 467 cyc1ohexylphenoxy methylpyrazol-5-yl 4-chloro-2- 3 , 5-dichlorophenyl 476 cyc1ohexylphenoxy 4-chloro-2- 2- (propylthio) pyridin-3-yl 482 cyc1ohexylphenoxy 4-chloro-2- 2-(ethylthio)pyridin-3-yl 468 cyc1ohexylphenoxy 4-chloro-2- 3-bromopyridin-5-yl 487 cyc1ohexylphenoxy 4-chloro-2- 4-methyl-l, 2, 3-thiadiazol- 429 cyc1ohexylphenoxy 5-yl 4-chloro-2- l-methyl-3-(2-(2- 467 cyc1ohexylphenoxy methyl )propyl )pyrazol-5-yl 4-chloro-2- 3-chlorobenzo[b] thiophen- 497 cyc1ohexylphenoxy 2-yl 4-chloro-2- 4-chlorophenyl 441 cyc1ohexylphenoxy 4-chloro-2- 4-methyl-2-phenyl-l,2,3- 488 cyc1ohexylphenoxy triazol-5-yl 4-chloro-2- benzo [b] thiophen-2-yl 463 cyc1ohexylphenoxy 4-chloro-2- 3, 4-dimethyIphenyl 435 cyc1ohexylphenoxy 4-chloro-2- 2- (phenoxy) pyridin-3-yl 500 cyc1ohexylphenoxy 4-chloro-2- 2- (methylthio) pyridin-3-yl 454 cyc1ohexylphenoxy 4-chloro-2- 5-methyl-3-phenylisoxazol- 488 cyc1ohexylphenoxy 4-yl 4-chloro-2- 4-chloro-l,3-dimethyl 510 cyc1ohexylphenoxy pyrazolo [3, 4-b]pyridin-3- yi 4-chloro-2- 2-chloro-6-methylpyridin- 456 cyc1ohexylphenoxy 4-yl 4-chloro-2- 3 , 5-dimethylisoxazol-4-yl 426 cyclohexylphenoxy 4-chloro-2- 1-naphthyl 457 cyc1ohexylphenoxy 4-chloro-2- 2-fluorophenyl 425 cyc1ohexylphenoxy 4-chloro-2- 4-propylphenyl 449 cyc1ohexylphenoxy 4-chloro-2- 3-fluorophenyl 425 cyc1ohexylphenoxy 4-chloro-2- 2 , 6-difluorophenyl 443 cyc1ohexylphenoxy 4-chloro-2- 2-chlorophenyl 441 cyc1ohexylphenoxy 4-chloro-2- 3- (chloromethyl ) phenyl 455 cyc1ohexylphenoxy 4-chloro-2- 4-(2-(2- 463 cyc1ohexylphenoxy methyl ) propyl ) phenyl 4-chloro-2- 3-chlorophenyl 441 cyc1ohexylphenoxy 4-chloro-2- 3 , 5-dimethoxyphenyl 467 cyc1ohexylphenoxy 4-chloro-2- 2 , 6-dichlorophenyl 476 cyclohexylphenoxy 4-chloro-2- 2 , 4-dichlorophenyl 476 cyc1ohexylphenoxy 4-chloro-2- 4-fluorophenyl 425 cyclohexylphenoxy 4-chloro-2- 4-butyIphenyl 463 cyc1ohexylphenoxy 4-chloro-2- 2-methylphenyl 421 cyc1ohexylphenoxy 4-chloro-2- phenyl 407 cyclohexylphenoxy 4-chloro-2- 4-ethylphenyl 435 cyc1ohexylphenoxy 4-chloro-2- 2 , 3-difluorophenyl 443 cyc1ohexylphenoxy 4-chloro-2- 2 , 6-dimethoxyphenyl 467 cyc1ohexylphenoxy 4-chloro-2- 3 , 4-difluorophenyl 443 cyc1ohexylphenoxy 4-chloro-2- 2 , 5-difluorophenyl 443 cyc1ohexylphenoxy 4-chloro-2- 4-ethoxyphenyl 451 cyc1ohexylphenoxy 4-chloro-2- 2,4, 6-trichlorophenyl 510 cyc1ohexylphenoxy 4-chloro-2- 3 -methylphenyl 421 cyc1ohexylphenoxy 4-chloro-2- 2-fluoro-5- 493 cyc1ohexylphenoxy (trifluoromethyl ) phenyl 4-chloro-2- 3 -methoxyphenyl 437 cyc1ohexylphenoxy 4-chloro-2- 2-bromophenyl 486 cyclohexylphenoxy 4-chloro-2- 4-bromophenyl 486 cyc1ohexylphenoxy 4-chloro-2- 4-fluoro-3- 493 cyc1ohexylphenoxy ( trifluoromethyl ) phenyl 4-chloro-2- 3- (trifluoromethoxy) phenyl 491 cyc1ohexylphenoxy 4-chloro-2- 9-fluorenon-4-yl 503 cyclohexylphenoxy 4-chloro-2- isoxazol-5-yl 398 cyclohexylphenoxy 4-chloro-2- benzofuroxan-5-yl 465 cyclohexylphenoxy 4-chloro-2- 2-chloropyrid-3-yl 442 cyc1ohexylphenoxy 4-chloro-2- 2-(4- 514 cyc1ohexylphenoxy methylphenoxy) pyridin-3 -yl 4-chloro-2- pyridin-4-yl 408 cyc1ohexylphenoxy 4-chloro-2- anthraquinon-2-y1 537 cyc1ohexylphenoxy 4-chloro-2- 2-iodophenyl 533 cyc1ohexylphenoxy 4-chloro-2- 4-pentyIphenyl 477 cyc1ohexylphenoxy 4-chloro-2- 2- (4-chlorophenylthio) 550 cyc1ohexylphenoxy pyridin-3-yl 4-chloro-2- 2 , 6-dimethylphenyl 435 cyc1ohexylphenoxy 4-chloro-2- 2 , 5-dimethoxyphenyl 467 cyclohexylphenoxy 4 -chloro-2 - 2 , 5-dichloropyridin-3-yl 477 cyc1ohexylphenoxy 4-chloro-2- 2-chloro-6-methoxypyridin- 472 cyclohexylphenoxy 4-yl 4-chloro-2- 2 , 3-dichloropyridin-5-yl 477 cyc1ohexylphenoxy 4-chloro-2- 1-naphthyl 471 cyc1ohexylphenoxy 4-chloro-2- 2 , 4-dimethoxyphenyl 467 cyc1ohexylphenoxy 4-chloro-2- 3,5- 546 cyc1ohexylphenoxy bis ( trifluoromethyl ) phenyl 4-chloro-2- 2-(4- 534 cyc1ohexylphenoxy chlorophenoxy) pyridin-3-yl 4-chloro-2- pentafluorophenyl 497 cyc1ohexylphenoxy 4-chloro-3 , 5- 3 , 4-dimethoxyphenyl 413 dimethylphenoxy 4-chloro-3 , 5- 2 - ( trif luoromethyl ) phenyl 421 dimethylphenoxy 4-chloro-3 , 5- 2 , 4-difluorophenyl 389 dimethylphenoxy 4-chloro-3 , 5- 3- (trifluoromethyl) phenyl 421 dimethylphenoxy 4-chloro-3 , 5- 2-naphthyl 403 dimethylphenoxy 4-chloro-3 , 5- 2 -methoxyphenyl 484 dimethylphenoxy 4-chloro-3 , 5- 3,4, 5-trimethylphenyl 443 dimethylphenoxy 4-chloro-3 , 5- 3 , 4-dichlorophenyl 422 dimethylphenoxy 4-chloro-3 , 5- 3 -bromophenyl 432 dimethylphenoxy 4-chloro-3 , 5- 3-pyridyl 354 di ethylphenoxy 4-chloro-3 , 5- 2-ethoxynaphth-1-y1 447 dimethylphenoxy 4-chloro-3 , 5- 2 , 3 -dichlorophenyl 422 dimethylphenoxy 4-chloro-3 , 5- 6-chloropyrid-3-y1 388 dimethylphenoxy 4-chloro-3 , 5- 4- (trifluoromethoxy) phenyl 437 dimethylphenoxy 4-chloro-3 , 5- 2-fluoro-4- 439 dimethylphenoxy ( trifluoromethyl ) phenyl 4-chloro-3 , 5- 3-bromothienyl 438 dimethylphenoxy 4-chloro-3 , 5- 2-acetoxyphenyl 411 dimethylphenoxy 4-chloro-3 , 5- 5-methylisoxazol-3-yl 358 di ethylphenoxy 4-chloro-3 , 5- 2- (phenylthio) pyrid-3-yl 462 di ethylphenoxy 4-chloro-3 , 5- 2- (trifluoromethoxy) phenyl 437 dimethylphenoxy 4-chloro-3 , 5- 1-phenyl-5-propyIpyrazin- 461 dimethylphenoxy 4-yl 4-chloro-3 , 5- 2-ethoxyphenyl 397 dimethylphenoxy 4-chloro-3 , 5- 3-chlorothien-2-yl 393 dimethylphenoxy 4-chloro-3 , 5- l-(2-(2-methyl)propyl)-3- 413 dimethylphenoxy methylpyrazol-5-yl 4-chloro-3 , 5- 3 , 5-dichlorophenyl 422 dimethylphenoxy 4-chloro-3 , 5- 2- (propylthio) pyridin-3 -yl 428 dimethylphenoxy 4-chloro-3 , 5- 2-(ethylthio)pyridin-3-yl 414 di ethylphenoxy 4-chloro-3 , 5- 3-bromopyridin-5-yl 433 dimethylphenoxy 4-chloro-3 , 5- 4-methyl-l, 2, 3-thiadiazol- 375 dimethylphenoxy 5-yl 4-chloro-3 , 5- l-methyl-3-(2-(2- 413 di ethylphenoxy methyl ) propyl ) pyrazol-5-y1 4-chloro-3 , 5- 3-chlorobenzo[b] thiophen- 443 dimethylphenoxy 2-yl 4-chloro-3 , 5- 4-chlorophenyl 387 dimethylphenoxy 4-chloro-3 , 5- 4-methyl-2-phenyl-l,2,3- 434 di ethylphenoxy triazol-5-yl 4-chloro-3 , 5- benzo [b] thiophen-2-yl 409 dimethylphenoxy 4-chloro-3 , 5- 3, 4-dimethyIphenyl 381 dimethylphenoxy 4-chloro-3 , 5- 2- (phenoxy) pyridin-3-yl 446 dimethylphenoxy 4-chloro-3 , 5- 2- (methylthio)pyridin-3-yl 400 dimethylphenoxy 4-chloro-3, 5- 5-methyl-3-phenylisoxazol- 434 dimethylphenoxy 4-yl 4-chloro-3 , 5- 4-chloro-1 , 3-dimethyl 456 dimethylphenoxy pyrazolo [3, 4-b]pyridin-3- yi 4-chloro-3 , 5- 2-chloro-6-methylpyridin- 402 dimethylphenoxy 4-yl 4-chloro-3 , 5- 3 , 5-dimethylisoxazol-4-yl 372 dimethylphenoxy 4-chloro-3 , 5- 1-naphthyl 403 dimethylphenoxy 4-chloro-3 , 5- 2-fluorophenyl 371 dimethylphenoxy 4-chloro-3 , 5- 4-propyIphenyl 395 di ethylphenoxy 4-chloro-3 , 5- 3 - fluorophenyl 371 dimethylphenoxy 4-chloro-3 , 5- 2 , 6-difluorophenyl 389 dimethylphenoxy 4-chloro-3 , 5- 2-chlorophenyl 387 dimethylphenoxy 4-chloro-3 , 5- 3 - ( chloromethyl ) phenyl 401 dimethylphenoxy 4-chloro-3 , 5- 4-(2-(2- 409 dimethylphenoxy methyl ) propyl ) phenyl 4-chloro-3 , 5- 3 -chlorophenyl 387 dimethylphenoxy 4-chloro-3 , 5- 3 , 5-dimethoxyphenyl 413 di ethylphenoxy 4-chloro-3 , 5- 2 , 6-dichlorophenyl 422 dimethylphenoxy 4-chloro-3, 5- 2 , 4-dichlorophenyl 422 dimethylphenoxy 4-chloro-3 , 5- 4-fluorophenyl 371 dimethylphenoxy 4-chloro-3 , 5- 4-butylphenyl 409 di ethylphenoxy 4-chloro-3 , 5- 2-methylphenyl 367 di ethylphenoxy 4-chloro-3 , 5- phenyl 353 dimethylphenoxy 4-chloro-3 , 5- 4-ethyIphenyl 381 di ethylphenoxy 4-chloro-3 , 5- 2 , 3 -difluorophenyl 389 dimethylphenoxy 4-chloro-3 , 5- 2 , 6-dimethoxyphenyl 413 dimethylphenoxy 4-chloro-3 , 5- 3 , 4-difluorophenyl 389 dimethylphenoxy 4-chloro-3 , 5- 2 , 5-difluorophenyl 389 dimethylphenoxy 4-chloro-3 , 5- 4-ethoxyphenyl 397 dimethylphenoxy 4-chloro-3 , 5- 2,4, 6-trichlorophenyl 456 di ethylphenoxy 4-chloro-3 , 5- 3-methylphenyl 367 dimethylphenoxy 4-chloro-3 , 5- 2-fluoro-5- 439 dimethylphenoxy ( trifluoromethyl ) phenyl 4-chloro-3 , 5- 3-methoxyphenyl 383 dimethylphenoxy 4-chloro-3 , 5- 2-bromophenyl 432 dimethylphenoxy 4-chloro-3 , 5- 4-bromopheny1 432 dimethylphenoxy 4-chloro-3 , 5- 4-fluoro-3- 439 dimethylphenoxy ( trifluoromethyl ) phenyl 4-chloro-3 , 5- 3- (trifluoromethoxy) phenyl 437 dimethylphenoxy 4-chloro-3 , 5- 9 - fluorenon-4-yl 455 dimethylphenoxy 4-chloro-3 , 5- isoxazol-5-yl 344 dimethylphenoxy 4-chloro-3 , 5- benzofuroxan-5-yl 411 dimethylphenoxy 4-chloro-3 , 5- 2-chloropyrid-3-yl 388 dimethylphenoxy 4-chloro-3 , 5- 2-(4- 460 dimethylphenoxy methylphenoxy) pyridin-3-yl 4-chloro-3 , 5- pyridin-4-yl 354 dimethylphenoxy 4-chloro-3 , 5- anthraquinon-2-yl 483 dimethylphenoxy 4-chloro-3 , 5- 2-iodophenyl 479 dimethylphenoxy 4-chloro-3 , 5- 4-pentylphenyl 423 dimethylphenoxy 4-chloro-3 , 5- 2- (4-chlorophenylthio) 496 dimethylphenoxy pyridin-3 -yl 4-chloro-3 , 5- 2 , 6-dimethylphenyl 381 dimethylphenoxy 4-chloro-3 , 5- 2 , 5-dimethoxyphenyl 413 dimethylphenoxy 4-chloro-3, 5- 2, 5-dichloropyridin-3-yl 423 dimethylphenoxy 4-chloro-3 , 5- 2-chloro-6-methoxypyridin- 418 dimethylphenoxy 4-yl 4-chloro-3 , 5- 2, 3-dichloropyridin-5-yl 423 dimethylphenoxy 4-chloro-3 , 5- 1-naphthyl 417 dimethylphenoxy 4-chloro-3 , 5- 2 , 4-dimethoxyphenyl 413 dimethylphenoxy 4-chloro-3, 5- 3,5- 489 dimethylphenoxy bis (trifluoromethyl) phenyl 4-chloro-3 , 5- 2-(4- 480 dimethylphenoxy chlorophenoxy) pyridin-3 -yl 4-chloro-3 , 5- pentafluorophenyl 443 dimethylphenoxy pyrid-3-yloxy 3 , 4-dimethoxyphenyl 351 pyrid-3 -yloxy 2- (trifluoromethyl) phenyl 359 pyrid-3 -yloxy 2 , 4-difluorophenyl 327 pyrid-3-yloxy 3- (trifluoromethyl) phenyl 359 pyrid-3-yloxy 2 -naphthyl 341 pyrid-3-yloxy 2 -methoxyphenyl 321 pyrid-3-yloxy 3 , 4, 5-trimethylphenyl 381 pyrid-3-yloxy 3, 4-dichlorophenyl 360 pyrid-3 -y1oxy 3 -bromophenyl 370 pyrid-3 -y1oxy 3 -pyridyl 292 pyrid-3 -yloxy 2-ethoxynaphth-l-yl 385 pyrid-3 -yloxy 2, 3-dichlorophenyl 360 pyrid-3-yloxy 6-chloropyrid-3-yl 327 pyrid-3 -yloxy 4- (trifluoromethoxy) phenyl 375 pyrid-3-yloxy 2-fluoro-4- 377 ( trifluoromethyl ) phenyl pyrid-3-yloxy 3-bromothienyl 376 pyrid-3 -yloxy 2-acetoxyphenyl 349 pyrid-3-yloxy 5-methylisoxazol-3-yl 296 pyrid-3-yloxy 2- (phenylthio) pyrid-3-yl 400 pyrid-3-yloxy 2- (trifluoromethoxy) phenyl 375 pyrid-3 -yloxy 1-phenyl-5-propylpyrazin- 399 4-yl pyrid-3-yloxy 2-ethoxyphenyl 335 pyrid-3-yloxy 3-chlorothien-2-yl 332 pyrid-3-yloxy 1- (2- (2-methyl)propyl) -3- 351 methylpyrazol-5-yl pyrid-3-yloxy 3 , 5-dichlorophenyl 360 pyrid-3-yloxy 2- (propylthio) pyridin-3-yl 366 pyrid-3-yloxy 2- (ethylthio )pyridin-3-yl 352 pyrid-3 -yloxy 3-bromopyridin-5-yl 371 pyrid-3 -yloxy 4-methyl-l, 2 , 3-thiadiazol- 313 5-yl pyrid-3-yloxy l-methyl-3- (2- (2- 351 methyl ) propyl ) pyrazol-5-yl pyrid-3 -yloxy 3-chlorobenzo [b] thiophen- 382 2-yl pyrid-3 -yloxy 4-chlorophenyl 326 pyrid-3 -yloxy 4-methyl-2-phenyl-1,2,3- 372 triazol-5-yl pyrid-3 -yloxy benzo [b] thiophen-2-yl 347 pyrid-3 -yloxy 3 , 4-dimethylphenyl 319 pyrid-3-yloxy 2- (phenoxy) pyridin-3-yl 384 pyrid-3 -yloxy 2- (methylthio) pyridin-3-yl 338 pyrid-3 -yloxy 5-methyl-3-phenylisoxazol- 372 4-yl pyrid-3 -yloxy 4-chloro-1,3-dimethyl 395 pyrazolo [3 , 4-b]pyridin-3- yi pyrid-3-yloxy 2-chloro-6-methylpyridin- 341 4-yl pyrid-3-yloxy 3 , 5-dimethylisoxazol-4-yl 310 pyrid-3-yloxy 1-naphthyl 341 pyrid-3 -yloxy 2-fluorophenyl 309 pyrid-3 -yloxy 4-propylphenyl 333 pyrid-3-yloxy 3-fluorophenyl 309 pyrid-3-yloxy 2 , 6-difluorophenyl 327 pyrid-3-yloxy 2-chlorophenyl 326 pyrid-3-yloxy 3 - ( chloromethyl )phenyl 340 pyrid-3-yloxy 4-(2-(2- 347 methyl ) propyl ) phenyl pyrid-3-yloxy 3 -chlorophenyl 326 pyrid-3-yloxy 3 , 5-dimethoxyphenyl 351 pyrid-3-yloxy 2 , 6-dichlorophenyl 360 pyrid-3 -yloxy 2 , 4-dichlorophenyl 360 pyrid-3 -yloxy 4-fluorophenyl 309 pyrid-3-yloxy 4-butyIphenyl 347 pyrid-3-yloxy 2-methylphenyl 305 pyrid-3 -yloxy phenyl 291 pyrid-3 -yloxy 4-ethylphenyl 319 pyrid-3 -yloxy 2 , 3-difluorophenyl 327 pyrid-3 -yloxy 2 , 6-dimethoxyphenyl 351 pyrid-3-yloxy 3 , 4-difluorophenyl 327 pyrid-3-yloxy 2 , 5-difluorophenyl 327 pyrid-3-yloxy 4-ethoxyphenyl 335 pyrid-3-yloxy 2,4, 6-trichlorophenyl 395 pyrid-3-yloxy 3-methylphenyl 305 pyrid-3-yloxy 2-fluoro-5- 377 ( trifluoromethyl ) phenyl pyrid-3-yloxy 3 -methoxyphenyl 321 pyrid-3-yloxy 2-bromophenyl 370 pyrid-3-yloxy 4-bromophenyl 370 pyrid-3-yloxy 4-fluoro-3- 377 ( trifluoromethyl ) phenyl pyrid-3-yloxy 3- (trifluoromethoxy) phenyl 375 pyrid-3-yloxy 9-fluorenon-4-yl 393 pyrid-3-yloxy isoxazol-5-yl 282 pyrid-3-yloxy benzofuroxan-5-y1 349 pyrid-3-yloxy 2-chloropyrid-3-yl 327 pyrid-3-yloxy 2-(4- 398 methylphenoxy) pyridin-3-yl pyrid-3-yloxy pyridin-4-yl 292 pyrid-3-yloxy anthraquinon-2-yl 421 pyrid-3-yloxy 2-iodophenyl 417 pyrid-3-yloxy 4-pentyIphenyl 361 pyrid-3-yloxy 2- (4-chlorophenylthio) 435 pyridin-3-yl pyrid-3-yloxy 2 , 6-dimethylphenyl 319 pyrid-3-yloxy 2 , 5-dimethoxyphenyl 354 pyrid-3-yloxy 2 , 5-dichloropyridin-3-yl 361 pyrid-3 -yloxy 2-chloro-6-methoxypyridin- 357 4-yl pyrid-3 -yloxy 2 , 3-dichloropyridin-5-yl 361 pyrid-3-yloxy 1-naphthyl 355 pyrid-3-yloxy 2 , 4-dimethoxyphenyl 351 pyrid-3 -yloxy 3,5- 427 bis ( trifluoromethyl ) phenyl pyrid-3 -yloxy 2-(4- 419 chlorophenoxy)pyridin-3-y1 pyrid-3 -yloxy pentafluorophenyl 381 4-bromophenoxy 3 , 4-dimethoxyphenyl 429 4-bromophenoxy 2- (trifluoromethyl) phenyl 437 4-bromophenoxy 2 , 4-difluorophenyl 405 4-bromophenoxy 3- (trifluoromethyl) phenyl 437 4-bromophenoxy 2-naphthyl 419 4-bromophenoxy 2-methoxyphenyl 399 4-bromophenoxy 3,4, 5-trimethyIphenyl 459 4-bromophenoxy 3 , 4-dichlorophenyl 438 4-bromophenoxy 3-bromophenyl 448 4-bromophenoxy 3-pyridyl 370 4-bromophenoxy 2-ethoxynaphth-l-yl 463 4-bromophenoxy 2 , 3-dichlorophenyl 438 4-bromophenoxy 6-chloropyrid-3-yl 405 4-bromophenoxy 4- (trifluoromethoxy) phenyl 453 4-bromophenoxy 2-fluoro-4- 455 ( trifluoromethyl ) phenyl 4-bromophenoxy 3-bromothienyl 454 4-bromophenoxy 2-acetoxvphenvl 427 -bromophenoxy 5-methylisoxazol-3-yl 374 -bromophenoxy 2- (phenylthio)pyrid-3-yl 478 -bromophenoxy 2- (trifluoromethoxy) phenyl 453 -bromophenoxy l-phenyl-5-propylpyrazin- 477 4-yl -bromophenoxy 2-ethoxyphenyl 413 -bromophenoxy 3-chlorothien-2-yl 410 -bromophenoxy l-(2-(2-methyl)propyl)-3- 429 methylpyrazol-5-yl -bromophenoxy 3 , 5-dichlorophenyl 438 -bromophenoxy 2- (propylthio) pyridin-3-yl 444 -bromophenoxy 2-(ethylthio)pyridin-3-yl 430 -bromophenoxy 3-bromopyridin-5-yl 449 -bromophenoxy 4-methyl-l, 2, 3-thiadiazol- 391 5-yl -bromophenoxy l-methyl-3-(2-(2- 429 methyl ) propyl ) pyrazol-5-yl -bromophenoxy 3-chlorobenzo[b] thiophen- 460 2-yl -bromophenoxy 4-chlorophenyl 404 -bromophenoxy 4-methyl-2-phenyl-l,2,3- 450 triazol-5-yl -bromophenoxy benzo [b] thiophen-2-yl 425 -bromophenoxy 3, 4-dimethyIphenyl 397 -bromophenoxy 2- (phenoxy) pyridin-3-yl 462 -bromophenoxy 2- (methylthio) pyridin-3-yl 416 -bromophenoxy 5-methyl-3-phenylisoxazol- 450 4-yl -bromophenoxy 4-chloro-l, 3 -dimethyl 473 pyrazolo [3 , 4-b]pyridin-3- yi -bromophenoxy 2-chloro-6-methylpyridin- 419 4-yl -bromophenoxy 3 , 5-dimethylisoxazol-4-yl 388 -bromophenoxy 1-naphthyl 419 -bromophenoxy 2-fluorophenyl 387 -bromophenoxy 4-propyIphenyl 411 -bromophenoxy 3-fluorophenyl 387 -bromophenoxy 2, 6-difluorophenyl 405 -bromophenoxy 2-chlorophenyl 414 -bromophenoxy 3- (chloromethyl) phenyl 418 -bromophenoxy 4-(2-(2- 425 methyl ) propyl ) phenyl -bromophenoxy 3-chlorophenyl 404 -bromophenoxy 3 , 5-dimethoxyphenyl 429 -bromophenoxy 2 , 6-dichlorophenyl 438 -bromophenoxy 2, 4-dichlorophenyl 438 -bromophenoxy 4-fluorophenyl 387 -bromophenoxy 4-butyIphenyl 425 -bromophenoxy 2-methylphenyl 383 -bromophenoxy phenyl 369 -bromophenoxy 4-ethylphenyl 397 -bromophenoxy 2, 3-difluorophenyl 405 -bromophenoxy 2 , 6-dimethoxyphenyl 429 -bromophenoxy 3 , 4-difluorophenyl 405 -bromophenoxy 2 , 5-difluorophenyl 405 -bromophenoxy 4-ethoxyphenyl 413 -bromophenoxy 2,4, 6-trichlorophenyl 473 -bromophenoxy 3-methylphenyl 383 -bromophenoxy 2-fluoro-5- 455 ( trifluoromethyl ) phenyl -bromophenoxy 3 -methoxyphenyl 399 -bromophenoxy 2-bromophenyl 448 -bromophenoxy 4-bromophenyl 448 -bromophenoxy 4-fluoro-3- 455 ( trifluoromethyl ) phenyl -bromophenoxy 3- (trifluoromethoxy) phenyl 453 -bromophenoxy 9-fluorenon-4-yl 471 -bromophenoxy isoxazol-5-yl 360 -bromophenoxy benzofuroxan-5-yl 427 -bromophenoxy 2-chloropyrid-3-yl 360 -bromophenoxy 2-{4- 476 methylphenoxy)pyridin-3-yl -bromophenoxy pyridin-4-yl 370 -bromophenoxy anthraquinon-2-yl 499 -bromophenoxy 2-iodophenyl 495 -bromophenoxy 4-pentyIphenyl 439 -bromophenoxy 2-(4- 513 chlorophenylthio) pyridin- 3-yl -bromophenoxy 2 , 6-dimethylphenyl 397 -bromophenoxy 2 , 5-dimethoxyphenyl 429 -bromophenoxy 2 , 5-dichloropyridin-3-yl 439 -bromophenoxy 2-chloro-6-methoxypyridin- 435 4-yl 4-bromophenoxy 2, 3-dichloropyridin-5-yl 439 4-bromophenoxy 1-naphthyl 433 4-bromophenoxy 2 , 4-dimethoxyphenyl 429 4-bromophenoxy 3,5- 505 bis (trifluoromethyl) phenyl 4-bromophenoxy 2-(4- 497 chlorophenoxy) pyridin-3-yl 4-bromophenoxy pentafluorophenyl 459 4-chloro-2- 4-biphenyl 431 methylphenylthio 4-chloro-2- 3 , 4-dimethoxyphenyl 415 ethylphenylthio 4-chloro-2- 2- (trifluoromethyl) phenyl 423 methylphenylthio 4-chloro-2- 2 , 4-difluorophenyl 391 methylphenylthio 4-chloro-2- 4-cyanopheny1 380 methylphenylthio 4-chloro-2- 3- (trifluoromethyl) phenyl 423 methylphenylthio 4-chloro-2- 3-cyanopheny1 380 ethyIphenylthio 4-chloro-2- 2-naphthyl 405 methylphenylthio 4-chloro-2- 2-methoxyphenyl 385 methylphenylthio 4-chloro-2- 3,4, 5-trimethyIphenyl 445 methylphenylthio 4-chloro-2- 4-nitrophenyl 400 methyIphenylthio 4-chloro-2 - 3 , 4-dichlorophenyl 424 methylphenylthio 4-chloro-2- 5-nitrofuran-2-yl 390 methylphenylthio 4-chloro-2- 3 -bromophenyl 434 methylphenylthio 4-chloro-2- 3 -pyridyl 356 methylphenylthio 4-chloro-2- 2-ethoxynaphth-l-yl 449 methylphenylthio 4-chloro-2- 2 , 3 -dichlorophenyl 424 methylphenylthio 4-chloro-2- 3-nitrophenyl 400 methylphenylthio 4-chloro-2- 6-chloropyrid-3-yl 390 methylphenylthio 4-chloro-2- 4- (trifluoromethoxy) phenyl 439 methyIphenylthio 4-chloro-2- 2-fluoro-4- 441 methylphenylthio ( trifluoromethyl ) phenyl 4-chloro-2- 3-bromothienyl 440 methylphenylthio 4-chloro-2- 2-acetoxyphenyl 413 methyIphenylthio 4-chloro-2- 5-methylisoxazol-3-yl 360 ethylphenylthio 4-chloro-2- 2- (phenylthio) pyrid-3 -yl 464 methylphenylthio 4-chloro-2- 2- (trifluoromethoxy) phenyl 439 methylphenylthio 4-chloro-2- 1-phenyl-5 -propyIpyrazin- 463 methyIphenylthio 4-yl 4-chloro-2- 2 -ethoxyphenyl 399 methylphenylthio 4-chloro-2- 3-chlorothien-2-yl 395 methylphenylthio 4-chloro-2- l-(2-(2-methyl)propyl)-3- 415 methylphenylthio methylpyrazol-5-yl 4-chloro-2- 3 , 5-dichlorophenyl 424 methylphenylthio 4-chloro-2- 2- (propylthio) pyridin-3-yl 430 ethylphenylthio 4-chloro-2- 2-(ethylthio)pyridin-3-yl 416 methylphenylthio 4-chloro-2- 3-bromopyridin-5-yl 435 ethylphenylthio 4-chloro-2- 4-methyl-l, 2, 3-thiadiazol- 377 methylphenylthio 5-yl 4-chloro-2- l-methyl-3-(2-(2- 415 methylphenylthio methyl ) propyl ) pyrazol- 5-yl 4-chloro-2- 3 -chlorobenzo[b] thiophen- 445 methylphenylthio 2-yl 4-chloro-2- 4-chlorophenyl 389 methylphenylthio 4-chloro-2- 4-methyl-2 -phenyl-1,2, 3- 436 methylphenylthio triazol-5-yl 4-chloro-2- benzo [b] thiophen-2-yl 411 methyIphenylthio 4-chloro-2- 3, 4-dimethyIphenyl 383 methylphenylthio 4-chloro-2 - 2- (phenoxy) pyridin-3 -yl 448 methylphenylthio 4-chloro-2- 2- (methylthio) pyridin-3-yl 402 methylphenylthio 4-chloro-2- 5-methyl-3-phenylisoxazol- 436 methylphenylthio 4-yl 4-chloro-2- 4-chloro-1,3-dimethyl 458 methylphenylthio pyrazolo [3 , 4-b]pyridin-3- yi 4-chloro-2- 2-chloro-6-methylpyridin- 404 methylphenylthio 4-yl 4-chloro-2- 3 , 5-dimethylisoxazol-4-yl 374 methylphenylthio 4-chloro-2- 1-naphthyl 405 methylphenylthio 4-chloro-2- 2-fluorophenyl 373 methylphenylthio 4-chloro-2- 4-propylpheny1 397 methylphenylthio 4-chloro-2- 4- (trifluoromethyl) phenyl 423 ethylphenylthio 4-chloro-2- 3-fluorophenyl 373 methylphenylthio 4-chloro-2- 2 , 6-difluorophenyl 391 ethylphenylthio 4-chloro-2- 2-chlorophenyl 389 methylphenylthio 4-chloro-2- 3 - (chloromethyl ) phenyl 403 ethylphenylthio 4-chloro-2- 4-(2-(2- 411 methylphenylthio methyl ) propyl ) phenyl 4-chloro-2- 3 -chlorophenyl 389 methylphenylthio 4-chloro-2- 2-nitrophenyl 400 methylphenylthio 4-chloro-2- 3 , 5-dimethoxyphenyl 415 methylphenylthio 4-chloro-2- 2 , 6-dichlorophenyl 424 methyIphenylthio 4-chloro-2- 2 , 4-dichlorophenyl 424 methylphenylthio 4-chloro-2- 4-fluorophenyl 373 methyIphenylthio 4-chloro-2- 4-butyIphenyl 411 methylphenylthio 4-chloro-2- 2-methylphenyl 369 methylphenylthio 4-chloro-2- phenyl 355 methylphenylthio 4-chloro-2- 4-ethylphenyl 383 methylphenylthio 4-chloro-2- 2 , 3 -difluorophenyl 391 methylphenylthio 4-chloro-2- 2 , 6-dimethoxyphenyl 415 methylphenylthio 4-chloro-2- 3 , 4-difluorophenyl 391 methylphenylthio 4-chloro-2- 2 , 5-difluorophenyl 391 methyIphenylthio 4-chloro-2- 4-ethoxyphenyl 399 methylphenylthio 4-chloro-2- 2,4, 6-trichlorophenyl 458 ethylphenylthio 4-chloro-2- 3 -methylphenyl 369 methylphenylthio 4-chloro-2- 2-fluoro-5- 441 methylphenylthio ( trifluoromethyl ) phenyl 4-chloro-2- 3 -methoxyphenyl 385 methylphenylthio 4-chloro-2- thien-2-yl 361 methylphenylthio 4-chloro-2- 2 -bromophenyl 434 methylphenylthio 4-chloro-2- 4-bromophenyl 434 methylphenylthio 4-chloro-2- 4-fluoro-3- 441 methylphenylthio ( trifluoromethyl ) phenyl 4-chloro-2- 3- (trifluoromethoxy) phenyl 439 methylphenylthio 4-chloro-2- 9 -fluorenon-4-y1 457 methylphenylthio 4-chloro-2- isoxazol-5-yl 346 methyIphenylthio 4-chloro-2- benzofuroxan-5-yl 413 methylphenylthio 4-chloro-2- 2-chloropyrid-3-yl 390 methylphenylthio 4-chloro-2- 3 , 5-difluorophenyl 391 methylphenylthio 4-chloro-2- 2-(4- 462 methylphenylthio methylphenoxy) pyridin-3 -yl 4-chloro-2- pyridin-4-yl 356 methylphenylthio 4-chloro-2- anthraquinon-2-y1 485 methylphenylthio 4-chloro-2- 2-iodophenyl 481 methylphenylthio 4-chloro-2- 4-biphenyl 414 methylanilino 4-chloro-2- 3 , 4-dimethoxyphenyl 398 methylanilino 4-chloro-2- 2- (trifluoromethyl) phenyl 406 methylanilino 4-chloro-2- 2 , 4-difluorophenyl 374 methylanilino 4-chloro-2- 4-cyanopheny1 363 methylanilino 4-chloro-2- 3- (trifluoromethyl) phenyl 406 methylanilino 4-chloro-2- 3 -cyanopheny1 363 methylanilino 4-chloro-2- 2-naphthyl 388 methylanilino 4-chloro-2- 2-methoxyphenyl 368 methylanilino 4-chloro-2- 3,4, 5-trimethylphenyl 428 methylanilino 4-chloro-2- 4-nitrophenyl 383 methylanilino 4-chloro-2- 3 , 4-dichlorophenyl 407 methylanilino 4-chloro-2- 5-nitrofuran-2-yl 373 methylanilino 4-chloro-2- 3-bromophenyl 417 methylanilino 4-chloro-2- 3-pyridyl 339 methylanilino 4-chloro-2- 2 -ethoxynaphth- 1-y1 432 methylanilino 4-chloro-2- 2 , 3 -dichlorophenyl 407 methylanilino 4-chloro-2- 3 -nitrophenyl 383 methylanilino 4-chloro-2- 6-chloropyrid-3 -yl 373 methylanilino 4-chloro-2- 4- (trifluoromethoxy) phenyl 422 methylanilino 4-chloro-2- 2-fluoro-4- 424 methylanilino ( trifluoromethyl ) phenyl 4-chloro-2- 3-bromothienyl 423 methylanilino 4-chloro-2- 2-acetoxyphenyl 396 methylanilino 4-chloro-2- 5-methylisoxazol-3-yl 343 methylanilino 4-chloro-2- 2- (phenylthio) pyrid-3-yl 447 methylanilino 4-chloro-2- 2- (trifluoromethoxy) phenyl 422 methylanilino 4-chloro-2- 1-phenyl-5-propylpyrazin- 446 methylanilino 4-yl 4-chloro-2- 2-ethoxyphenyl 382 methylanilino 4-chloro-2- 3-chlorothien-2-yl 378 methylanilino 4-chloro-2- l-(2-(2-methyl)propyl)-3- 398 methylanilino methylpyrazol-5-yl 4-chloro-2- 3 , 5-dichlorophenyl 407 methylanilino 4-chloro-2- 2- (propylthio) pyridin-3-yl 413 methylanilino 4-chloro-2- 2- (ethylthio)pyridin-3-yl 399 methylanilino 4-chloro-2- 3-bromopyridin-5-yl 418 ethylanilino 4-chloro-2- 4-methyl-l, 2, 3-thiadiazol- 360 methylanilino 5-yl 4-chloro-2- l-methyl-3-(2-(2- 398 methylanilino methyl ) propyl ) pyrazol- 5 -yl 4-chloro-2- 3 -chlorobenzo [b] thiophen- 428 methylanilino 2-yl 4-chloro-2- 4-chlorophenyl 372 methylanilino 4-chloro-2- 4-methyl-2-phenyl-l,2,3- 419 methylanilino triazol-5-yl 4-chloro-2- benzo [b] thiophen-2-yl 394 methylanilino 4-chloro-2- 3 , 4-dimethyIphenyl 366 methylanilino 4-chloro-2- 2- (phenoxy) pyridin-3-yl 431 methylanilino 4-chloro-2- 2- (methylthio) pyridin-3-yl 385 methylanilino 4-chloro-2- 5-methyl-3-phenylisoxazol- 419 methylanilino 4-yl 4-chloro-2- 4-chloro-l, 3-dimethyl 441 methylanilino pyrazolo [3 , 4-b]pyridin-3- yi 4-chloro-2- 2 -chloro-6-methylpyridin- 387 methylanilino 4-yl 4-chloro-2- 3 , 5-dimethylisoxazol-4-yl 357 methylanilino 4-chloro-2- 1-naphthyl 388 methylanilino 4-chloro-2- 2-fluorophenyl 356 methylanilino 4-chloro-2- 4-propylphenyl 380 methylanilino 4-chloro-2- 4- (trifluoromethyl) phenyl 406 methylanilino 4-chloro-2- 3 -fluorophenyl 356 methylanilino 4-chloro-2- 2 , 6-difluorophenyl 374 methylani1ino 4-chloro-2- 2 -chlorophenyl 372 methylanilino 4-chloro-2- 3 - (chloromethyl ) phenyl 386 methylanilino 4-chloro-2- 4-(2-(2- 394 methylanilino methyl ) propyl )phenyl 4-chloro-2- 3 -chlorophenyl 372 methylanilino 4-chloro-2- 2-nitrophenyl 383 methylanilino 4-chloro-2- 3 , 5-dimethoxyphenyl 398 methylanilino 4-chloro-2- 2 , 6-dichlorophenyl 407 methylanilino 4-chloro-2- 2 , 4-dichlorophenyl 407 methylanilino 4-chloro-2- 4-fluorophenyl 356 methylanilino 4-chloro-2- 4-butylphenyl 394 methylanilino 4-chloro-2- 2-methylphenyl 352 methylanilino 4-chloro-2- phenyl 338 methylanilino 4-chloro-2- 4-ethyIphenyl 366 methylanilino 4-chloro-2- 2 , 3-difluorophenyl 374 methylanilino 4-chloro-2- 2 , 6-dimethoxyphenyl 398 methylanilino 4-chloro-2- 3 , 4-difluorophenyl 374 methylanilino 4-chloro-2- 2 , 5-difluorophenyl 374 methylanilino 4-chloro-2- 4-ethoxyphenyl 382 methylanilino 4-chloro-2- 2,4, 6-trichlorophenyl 441 methylanilino 4-chloro-2- 3-methylphenyl 352 methylanilino 4-chloro-2- 2-fluoro-5- 424 methylanilino ( trifluoromethyl ) phenyl 4-chloro-2- 3 -methoxyphenyl 368 methylanilino 4-chloro-2- thien-2-yl 344 methyl nilino 4-chloro-2- 2-bromophenyl 417 methylanilino 4-chloro-2- 4-bromophenyl 417 methylanilino 4-chloro-2- 4-fluoro-3- 424 methylanilino ( trifluoromethyl ) phenyl 4-chloro-2- 3- (trifluoromethoxy) phenyl 422 methylanilino 4-chloro-2- 9-fluorenon-4-yl 440 methylanilino 4-chloro-2- isoxazol-5-yl 329 methylanilino 4-chloro-2- benzofuroxan-5-yl 396 methylani1ino 4-chloro-2- 2-chloropyrid-3-yl 373 methylani1ino 4-chloro-2- 3 , 5-difluorophenyl 374 methylanilino 4-chloro-2- 2-(4- 445 methylanilino methylphenoxy)pyridin-3-yl 4-chloro-2- pyridin-4-yl 339 methylanilino 4-chloro-2- anthraquinon-2-yl 468 methylanilino 4-chloro-2- 2-iodophenyl 464 methylanilino The compounds listed in Table 7 can be prepared from substituted 5-aminopyridine compounds and the appropriate acid chloride according to the general procedure above . Table 7 R J -chloro-2-methylphenoxy 3 , 4-dif luorphenyl -chloro-2-methylphenoxy 4 -pen ty Iphenyl -chloro-2-methylphenoxy 2- (4-chlorophenylthio) pyridin-3-yl -chloro-2-methylphenoxy 2 , 6-dimethylphenyl -chloro-2-methylphenoxy 2 , 5-dimethoxyphenyl -chloro-2-methylphenoxy 2 , 5-dichloropyridin-3-yl -chloro-2-methylphenoxy 2-chloro-6-methoxypyridin- 4-yl -chloro-2-methylphenoxy 2 , 3-dichloropyridin-5-yl -chloro-2-methylphenoxy 1-naphthyl -chloro-2-methylphenoxy 2 , 4-dimethoxyphenyl -chloro-2-methylphenoxy 3,5- bis (trifluoromethyl)phenyl -chloro-2-methylphenoxy 2-(4- chlorophenoxy) pyridin-3-yl -chloro-2-methylphenoxy pentafluorophenyl -naphthoxy 4-pentylpheny1 -naphthoxy 2- (4-chlorophenylthio) pyridin-3-yl -naphthoxy 2 , 6-dimethylphenyl -naphthoxy 2 , 5-dimethoxyphenyl -naphthoxy 2 , 5-dichloropyridin-3-yl -naphthoxy 2-chloro-6-methoxypyridin- 4-yl -naphthoxy 2 , 3-dichloropyridin-5-yl -naphthoxy 1-naphthyl -naphthoxy 2 , 4-dimethoxyphenyl -naphthoxy 3 , 5-bis (trifluoromethyl) phenyl -naphthoxy 2-(4- chlorophenoxy)pyridin-3-yl -naphthoxy pentafluorophenyl - ( 2 -propyl ) phenoxy 4-pentyIphenyl - ( 2-propyl ) phenoxy 2- (4-chlorophenylthio) pyridin-3-yl - (2-propyl ) phenoxy 2 , 6-dimethylphenyl - ( 2-propyl ) phenoxy 2 , 5-dimethoxyphenyl - ( 2 -propyl ) phenoxy 2 , 5-dichloropyridin-3-yl - ( 2-propyl ) phenoxy 2-chloro-6-methoxypyridin- 4-yl - ( 2-propyl ) phenoxy 2 , 3-dichloropyridin-5-yl - ( 2-propyl ) phenoxy 1-naphthyl - ( 2-propyl ) phenoxy 2 , 4-dimethoxyphenyl - ( 2 -propyl ) phenoxy 3 , 5-bis (trifluoromethyl) phenyl - (2-propyl ) phenoxy 2-(4- chlorophenoxy)pyridin-3-yl - ( 2-propyl ) phenoxy pentafluorophenyl -fluoro-5-methylphenoxy 4-pentylpheny1 -fluoro-5-methylphenoxy 2- (4-chlorophenylthio) pyridin-3-yl -fluoro-5-methylphenoxy 2 , 6-dimethylphenyl -fluoro-5-methylphenoxy 2 , 5-dimethoxyphenyl -fluoro-5-methylphenoxy 2 , 5-dichloropyridin-3-yl -fluoro-5-methylphenoxy 2-chloro-6-methoxypyridin- 4-yl -fluoro-5-methylphenoxy 2 , 3-dichloropyridin-5-yl -fluoro-5-methylphenoxy 1-naphthyl -fluoro-5-methylphenoxy 2 , 4-dimethoxyphenyl -fluoro-5-methylphenoxy 3 , 5-bis (trifluoromethyl) phenyl -fluoro-5-methylphenoxy 2-(4- chlorophenoxy) pyridin-3 -yl -fluoro-5-methylphenoxy pentafluorophenyl -methylpyrid-3-yloxy 4-pentyIphenyl -methylpyrid-3-yloxy 2- (4-chlorophenylthio) pyridin-3-yl -methylpyrid-3-yloxy 2 , 6-dimethylphenyl -methylpyrid-3-yloxy 2 , 5-dimethoxyphenyl -methylpyrid-3 -yloxy 2 , 5-dichloropyridin-3-yl -methylpyrid-3-yloxy 2-chloro-6-methoxypyridin- 4-yl -methylpyrid-3-yloxy 2 , 3-dichloropyridin-5-yl -methylpyrid-3-yloxy 1-naphthyl -methylpyrid-3-yloxy 2 , 4-dimethoxyphenyl -methylpyrid-3-yloxy 3 , 5-bis (trifluoromethyl) phenyl -methylpyrid-3-yloxy 2-(4- chlorophenoxy) pyridin-3 -y1 -methylpyrid-3-yloxy pentafluorophenyl -methoxyphenoxy 4-biphenyl -methoxyphenoxy 4-cyanopheny1 -methoxyphenoxy 3 -cyanopheny1 -methoxyphenoxy 4-nitrophenyl -methoxyphenoxy 5-nitrofuran-2-yl -methoxyphenoxy 3-nitrophenyl -methoxyphenoxy 4- (trifluoromethyl) phenyl -methoxyphenoxy 2-nitrophenyl -methoxyphenoxy thien-2-yl - ( 2-propoxy) phenoxy 4-biphenyl - (2-propoxy) phenoxy 4-cyanopheny1 - (2-propoxy) phenoxy 3-cyanopheny1 - (2-propoxy) phenoxy 4-nitrophenyl - (2-propoxy) phenoxy 5-nitrofuran-2-yl - (2-propoxy) phenoxy 3-nitrophenyl - (2-propoxy) phenoxy 2-nitrophenyl - (2-propoxy) phenoxy thien-2-yl - (2-propoxy)phenoxy 3 , 5-difluorophenyl -fluorophenoxy 4-biphenyl -fluorophenoxy 4-cyanopheny1 -fluorophenoxy 3-cyanopheny1 -fluorophenoxy 4-nitrophenyl -fluorophenoxy 5-nitrofuran-2-yl -fluorophenoxy 3-nitrophenyl -fluorophenoxy 2-nitrophenyl -fluorophenoxy 4- (trifluoromethyl)phenyl -fluorophenoxy thien-2-yl -fluorophenoxy 3 , 5-difluorophenyl -chlorophenoxy 4-biphenyl -chlorophenoxy 4-cyanopheny1 -chlorophenoxy 3-cyanopheny1 -chlorophenoxy 4-nitrophenyl -chlorophenoxy 5-nitrofuran-2-yl 4-chlorophenoxy 3 -nitrophenyl 4-chlorophenoxy 2 -nitrophenyl 4-chlorophenoxy 4- (trifluoromethyl) phenyl 4-chlorophenoxy thien-2-yl 4-chlorophenoxy 3 , 5-difluorophenyl 2 , 4-difluorophenoxy 4-biphenyl 2 , 4-difluorophenoxy 4-cyanopheny1 2 , 4-difluorophenoxy 3 -cyanopheny1 2 , 4-difluorophenoxy 4-nitrophenyl 2 , 4-difluorophenoxy 5-nitrofuran-2-yl 2 , 4-difluorophenoxy 3 -nitrophenyl 2 , 4-difluorophenoxy 4- (trifluoromethyl) phenyl 2 , 4-difluorophenoxy 2-nitrophenyl 4-chloro-2, 5- 4-biphenyl dimethylphenoxy 4-chloro-2 , 5- 4-cyanopheny1 dimethylphenoxy 4-chloro-2 , 5- 3-cyanopheny1 dimethylphenoxy 4-chloro-2, 5- 4-nitrophenyl dimethylphenoxy 4-chloro-2 , 5- 5-nitrofuran-2-yl dimethylphenoxy 4-chloro-2, 5- 3 -nitrophenyl dimethylphenoxy 4-chloro-2, 5- 4- (trifluoromethyl) phenyl dimethylphenoxy 4-chloro-2 , 5- 2-nitrophenyl dimethylphenoxy 4-chloro-2, 5- thien-2-yl dimethylphenoxy 4-chloro-2, 5- 3 , 5-difluorophenyl dimethylphenoxy 4-methoxyphenoxy 3 , 5-difluorophenyl 2- (2-propoxy) phenoxy 4- (trifluoromethyl) phenyl 2 , 4-difluorophenoxy thien-2-yl 2 , 4-difluorophenoxy 3 , 5-difluorophenyl 4-thiomethylphenoxy 4-biphenyl 4-thiomethylphenoxy 4-cyanopheny1 4-thiomethylphenoxy 3 -cyanopheny1 4-thiomethylphenoxy 4-nitrophenyl 4-thiomethylphenoxy 5-nitrofuran-2-yl 4-thiomethylphenoxy 3-nitrophenyl 4-thiomethylphenoxy 4- (trifluoromethyl) phenyl 4-thiomethylphenoxy 2-nitrophenyl 4-thiomethylphenoxy thien-2-yl 4-thiomethylphenoxy 3 , 5-difluorophenyl 4- (2- ( 2-methyl ) propyl ) 4-biphenyl phenoxy 4- ( 2- ( 2-methyl) propyl) 4-cyanopheny1 phenoxy 4- (2- (2-methyl) propyl) 3-cyanopheny1 phenoxy 4- (2- (2-methyl ) propyl ) 4-nitropheny1 phenoxy 4- (2- (2-methyl) propyl) 5-nitrofuran-2-yl phenoxy 4- (2- (2-methyl ) propyl ) 3-nitrophenyl phenoxy 4- (2- (2 -methyl) propyl) 4- (trifluoromethyl) phenyl phenoxy 4- ( 2- ( 2-methyl ) propyl ) 2 -nitrophenyl phenoxy 4- ( 2- ( 2-methyl ) propyl ) thien-2-yl phenoxy 4- ( 2- (2-methyl ) propyl ) 3 , 5-difluorophenyl phenoxy 2 , 3 -dimethylphenoxy 4-biphenyl 2 , 3 -dimethylphenoxy 4-cyanopheny1 2 , 3-dimethylphenoxy 3-cyanopheny1 2 , 3 -dimethylphenoxy 4-nitrophenyl 2 , 3-dimethylphenoxy 5-nitrofuran-2-yl 2 , 3 -dimethylphenoxy 3-nitrophenyl 2 , 3-dimethylphenoxy 4- ( trifluoromethyl ) phenyl 2 , 3 -dimethylphenoxy 2-nitrophenyl 2 , 3 -dimethylphenoxy thien-2-yl 2 , 3 -dimethylphenoxy 3 , 5-difluorophenyl 3 , 5- ( is-2-propyl ) phenoxy 4-biphenyl 3,5- (bis-2-propyl) phenoxy 4-cyanopheny1 3 , 5- ( is-2-propyl ) phenoxy 3-cyanopheny1 3,5- (bis-2-propyl) phenoxy 4-nitrophenyl 3 , 5- (bis-2-propyl ) phenoxy 5-nitrofuran-2-yl 3,5- (bis-2 -propyl) phenoxy 3-nitrophenyl 3 , 5- (bis-2-propyl) phenoxy 4- ( trifluoromethyl ) phenyl 3,5- (bis-2-propyl) phenoxy 2-nitrophenyl , 5- (bis-2-propyl ) phenoxy thien-2-yl , 5- (bis-2-propyl) phenoxy 3 , 5-difluorophenyl -trifluoromethyl phenoxy 4-biphenyl -trifluoromethyl phenoxy 4-cyanopheny1 -trifluoromethyl phenoxy 3 -cyanopheny1 -trifluoromethyl phenoxy 4-nitrophenyl -trifluoromethyl phenoxy 5-nitrofuran-2-yl -trifluoromethyl phenoxy 3 -nitrophenyl -trifluoromethyl phenoxy 4- (trifluoromethyl) phenyl -trifluoromethyl phenoxy 2-nitrophenyl -trifluoromethyl phenoxy thien-2-yl -trifluoromethyl phenoxy 3 , 5-difluorophenyl , 6-dichlorophenoxy 4-biphenyl , 6-dichlorophenoxy 4-cyanopheny1 , 6-dichlorophenoxy 3 -cyanopheny1 , 6-dichlorophenoxy -nitrophenyl , 6-dichlorophenoxy 5-nitrofuran-2-yl , 6-dichlorophenoxy 3-nitrophenyl , 6-dichlorophenoxy 4- (trifluoromethyl) phenyl , 6-dichlorophenoxy 2-nitrophenyl , 6-dichlorophenoxy thien-2-yl , 6-dichlorophenoxy 3 , 5-difluorophenyl , 4-dichlorophenoxy 4-biphenyl , 4-dichlorophenoxy 4-cyanopheny1 , 4-dichlorophenoxy 3 -cyanopheny1 , 4-dichlorophenoxy 4-nitrophenyl , 4-dichlorophenoxy 5-nitrofuran-2-yl , 4-dichlorophenoxy 3 -nitrophenyl 2 , 4-dichlorophenoxy 4- ( trifluoromethyl ) phenyl 2 , 4-dichlorophenoxy 2-nitrophenyl 2 , 4-dichlorophenoxy thien-2-yl 2 , 4-dichlorophenoxy 3 , 5-difluorophenyl 4-chloro-3 -methylphenoxy 4-biphenyl 4-chloro-3 -methylphenoxy 4-cyanopheny1 4-chloro-3-methylphenoxy 3-cyanopheny1 4-chloro-3 -methylphenoxy 4-nitrophenyl 4-chloro-3 -methylphenoxy 5-nitrofuran-2-yl 4-chloro-3 -methylphenoxy 3-nitrophenyl 4-chloro-3-methylphenoxy 2-nitrophenyl 4-chloro-3 -methylphenoxy thien-2-yl 4-chloro-3 -methylphenoxy 3 , 5-difluorophenyl 4-chloro-2- 4-biphenyl cyc1ohexylphenoxy 4-chloro-2- 4-cyanopheny1 cyclohexylphenoxy 4-chloro-2- 3-cyanopheny1 cyclohexylphenoxy 4-chloro-2- 4-nitrophenyl cyc1ohexylphenoxy 4-chloro-2- 5-nitrofuran-2-yl cyc1ohexylphenoxy 4-chloro-2- 3-nitrophenyl cyc1ohexylphenoxy 4-chloro-2- 4- (trifluoromethyl) phenyl cyc1ohexylphenoxy 4-chloro-2- 2-nitrophenyl cyc1ohexylphenoxy 4-chloro-2- thien-2-yl cyc1ohexylphenoxy 4-chloro-2- 3 , 5-difluorophenyl cyc1ohexylphenoxy 4-chloro-3 , 5- 4-biphenyl dimethylphenoxy 4-chloro-3 , 5- 4-cyanopheny1 dimethylphenoxy 4-chloro-3 , 5- 3-cyanopheny1 dimethylphenoxy 4-chloro-3 , 5- 4-nitrophenyl dimethylphenoxy 4-chloro-3 , 5- 5-nitrofuran-2-yl di ethylphenoxy 4-chloro-3 , 5- 3-nitrophenyl dimethylphenoxy 4-chloro-3 , 5- 4- (trifluoromethyl) phenyl dimethylphenoxy 4-chloro-3 , 5- 2-nitrophenyl dimethylphenoxy 4-chloro-3 , 5- thien-2-yl dimethylphenoxy 4-chloro-3 , 5- 3 , 5-difluorophenyl dimethylphenoxy pyrid-3-yloxy 4-biphenyl pyrid-3-yloxy 4-cyanopheny1 pyrid-3-yloxy 3-cyanophenyl pyrid-3-yloxy 4-nitrophenyl pyrid-3-yloxy 5-nitrofuran-2-yl pyrid-3-yloxy 3-nitrophenyl pyrid-3 -yloxy 4- ( trifluoromethyl ) phenyl pyrid-3 -yloxy 2-nitrophenyl pyrid-3 -yloxy thien-2-yl pyrid-3 -yloxy 3 , 5-difluorophenyl 4-bromophenoxy 4-biphenyl 4-bromophenoxy 4-cyanopheny1 4-bromophenoxy 3 -cyanopheny1 4-bromophenoxy 4-nitrophenyl 4-bromophenoxy 5-nitrofuran-2-yl 4-bromophenoxy 3 -nitrophenyl 4-bromophenoxy 4- ( trifluoromethyl ) phenyl 4-bromophenoxy 2-nitrophenyl 4-bromophenoxy thien-2-yl 4-bromophenoxy 3 , 5-difluorophenyl 4-chloro-2- 4-pentyIphenyl methylphenylthio 4-chloro-2- 2- (4-chlorophenylthio) ethylphenylthio pyridin-3-yl 4-chloro-2- 2 , 6-dimethylphenyl methylphenylthio 4-chloro-2- 2 , 5-dimethoxyphenyl methyIphenylthio 4-chloro-2- 2 , 5-dichloropyridin-3-yl methyIphenylthio 4-chloro-2- 2-chloro-6-methoxypyridin- methylphenylthio 4-yl 4-chloro-2- 2 , 3-dichloropyridin-5-yl methylphenylthio 4-chloro-2- 1-naphthyl methylphenylthio 4-chloro-2- 2 , 4-dimethoxyphenyl ethylphenylthio 4-chloro-2- 3 , 5-bis (trifluoromethyl) methylphenylthio phenyl 4-chloro-2- 2-(4- methylphenylthio chlorophenoxy)pyridin-3-yl 4-chloro-2- pentafluorophenyl m thylphenylthio 4-chloro-2-methylanilino 4-pentyIphenyl 4-chloro-2-methylanilino 2- (4-chlorophenylthio) pyridin-3-yl 4-chloro-2-methylanilino 2 , 6-dimethylphenyl 4-chloro-2-methylanilino 2 , 5-dimethoxyphenyl 4-chloro-2-methylanilino 2, 5-dichloropyridin-3-yl 4-chloro-2-methylanilino 2-chloro-6-methoxypyridin- 4-yl 4-chloro-2-methylanilino 2 , 3-dichloropyridin-5-yl 4-chloro-2-methylanilino 1-naphthyl 4-chloro-2-methylanilino 2 , 4-dimethoxyphenyl 4-chloro-2-methylanilino 3,5- bis (trifluoromethyl) phenyl 4-chloro-2-methylanilino 2-(4- chlorophenoxy) pyridin-3 -yl 4-chloro-2-methylanilino pentafluorophenyl Example 19 General procedure for the synthesis of 6- (substituted- amino) -N-substituted nicotinamides Step A. General procedure for the preparation of 6- chloro-N-substituted nicotinamide : To a suspension of 6-chloronicotinoyl chloride (1.76 g, 10.0 mmol) in dry dichloromethane (10 mL) was added the amine (R 3 RNH) (10.0 mmol) followed by the dropwise addition of triethylamine (1.7 mL, 12.2 mmol). After stirring for 40 min. at room temperature, the mixture was diluted with dichloromethane, washed with aqueous 1 M hydrochloric acid, saturated aqueous sodium hydrogencarbonate and water, dried over sodium sulfate and concentrated to dryness under reduce pressure to afford the desired nicotinamide. The following compounds were prepared according to this procedure using the appropriate substituted amine: 6-Chloro-N-o-tolylnicotinamide: MS (m/z) : 247/249 (M+H) * ; C 13 H U C1 1 N 2 0 1 requires 246.5. 6-Chloro-N- (2-fluorophenyl) nicotinamide: MS (m/z) : 251/253 (M+H) * ; C^H.Cl^N.0, requires 250.7. 6-Chloro-N- (2, 6-dimethylphenyl) nicotinamide: MS (m/z) : 261/263 (M+H) * ; C 14 H 13 C1 1 N 2 0 1 requires 260.7. 6-Chloro-N- (2-phenoxyphenyl) nicotinamide: MS (m/z) : 325/327 (M+H) * ; C^H^l^O, requires 324.8. 6-Chloro-N-phenylnicotinamide: MS (m/z) : 233/235 (M+H) * ; requires 232.7. 6-Chloro-N- (2, 4-difluorophenyl) nicotinamide: MS (m/z) 269/271 (M+H) * ; C^Cl^N^ requires 268.6. 6-Chloro-N- (2, 6-diisopropyIphenyl) nicotinamide : MS (m/z) : 317/319 (M+H) * ; C^Cl^A requires 316.8. 6-Chloro-N- (4-chlorophenyl) -N-methylnicotinamide: MS (m/z) : 281/283 (M+H) * ; C u 1 ia Cl 2 ^ 2 l requires 281.1. 6-Chloro-N- (2, 4-dimethoxyphenyl) nicotinamide: MS (m/z) : 293/295 (M+H) * ; C^H^Cl^.O j requires 292.7. 6-Chloro-N- (3 -methoxyphenyl) nicotinamide: MS (m/z) 263/265 (M+H) * ; C^H^C^N.O. requires 262.7. 6-Chloro-N- (4-methoxyphenyl) nicotinamide: MS (m/z) : 263/265 (M+H) * ; C 13 H,.C1,N 2 0 2 requires 262.7. 6-Chloro-N- (2-methoxyphenyl) nicotinamide: MS (m/z) : 263/265 (M+H) * ; C 13 H 11 C1 1 N 2 0 2 requires 262.7. 6-Chloro-N-methyl-N-phenylnicotinamide : MS (m/z) : 247/249 (M+H) * ; C^Cl^^ requires 246.7. N-Benzyl-6-chloronicotinamide: MS (m/z) : 247/249 (M+H) * ; C 13 H 11 C1 1 N 2 0 1 requires 246.7. Step B. General procedure for the preparation of 6- (substituted-amino) -N-substituted nicotinamides A mixture of the 6-chloro-N-substituted nicotinamide (12.5 mmol) and amine (R X NH 2 or R'NHCH,) (20 mmol) in ethylene glycol (50 mL) or pyridine (alkylamines) (50 mL) was heated to 140°C for 20 hours. After cooling to room temperature, the mixture was diluted with dichloromethane/methanol (9:1, 250 mL) and filtered through a plug of silica gel, washing with additional dichloromethane/methanol (9:1, 250 mL) . Concentration under reduced pressure afforded the desired 6- (substituted-amino) -N-substituted nicotinamide. The compounds listed in Tables 8-11 were prepared from 6-chloro-N-substituted nicotinamides compounds and the appropriate amine according to the general procedure above . El MS (m/z) o-tolyl phenyl 303 o-tolyl o-tolyl 317 o-tolyl 4-chloro- -2- -methylphenyl 352 o-tolyl 2-fluorophenyl 321 o-tolyl 3-fluorophenyl 321 o-tolyl 4-fluorophenyl 321 o-tolyl 2 , 4-difluorophenyl 339 o-tolyl 2-methoxyphenyl 333 o-tolyl 3-methoxyphenyl 333 o-tolyl 4-methoxyphenyl 333 o-tolyl 2 , 4-dimethoxyphenyl 363 o-tolyl 2 -phenoxyphenyl 395 o-tolyl 3 -phenoxyphenyl 395 o-tolyl 4-phenoxyphenyl 395 o-tolyl 4-biphenyl 379 o-tolyl 4-benzylphenyl 393 o-tolyl 4- (trifluoromethoxy) phenyl 387 o-tolyl eye1ohexy1 309 o-tolyl 2-methylcyclohexyl 323 o-tolyl cycloheptyl 323 o-tolyl indan-1-yl 343 o-tolyl 2-dicyclohexyl 492 2-fluorophenyl phenyl 307 2 -fluorophenyl o-tolyl 321 2-fluorophenyl 4-chloro-2-methylphenyl 356 2-fluorophenyl 2-fluorophenyl 325 2-fluorophenyl 3-fluorophenyl 325 2-fluorophenyl 4-fluorophenyl 325 2-fluorophenyl 2 , 4-difluorophenyl 343 2 -fluorophenyl 2-methoxyphenyl 337 2 -fluorophenyl 3 -methoxyphenyl 337 2-fluorophenyl 4-methoxyphenyl 337 -fluorophenyl 2 , 4-dimethoxyphenyl 367 - fluorophenyl 2 -phenoxyphenyl 399 - fluorophenyl 3 -phenoxyphenyl 399 -fluorophenyl 4-phenoxyphenyl 399 -fluorophenyl 4-biphenyl 383 - fluorophenyl 4-benzylphenyl 397 - fluorophenyl 4- (trifluoromethoxy) phenyl 391 -fluorophenyl cyclohexyl 313 - fluorophenyl 2 -methyleye1ohexy1 327 - fluorophenyl cycloheptyl 327 -fluorophenyl indan-1-yl 347 -fluorophenyl 2 -dicyclohexyl 395 , 6-dimethylphenyl phenyl 317 , 6-dimethylphenyl o-tolyl 331 , 6-dimethylphenyl 4-chloro-2-methylphenyl 366 , 6-dimethylphenyl 2-fluorophenyl 335 , 6-dimethylphenyl 3 -fluorophenyl 335 , 6-dimethylphenyl 4-fluorophenyl 335 , 6-dimethylphenyl 2 , 4-difluorophenyl 353 , 6-dimethylphenyl 2-methoxyphenyl 347 , 6-dimethylphenyl 3 -methoxyphenyl 347 , 6-dimethylphenyl 4-methoxyphenyl 347 , 6-dimethylphenyl 2 , 4-dimethoxyphenyl 377 , 6-dimethylphenyl 2 -phenoxyphenyl 409 , 6-dimethylphenyl 3 -phenoxyphenyl 409 , 6 -dimethylphenyl 4-phenoxyphenyl 409 , 6-dimethylphenyl 4-biphenyl 393 , 6 -dimethylphenyl 4-benzylphenyl 407 , 6 -dimethylphenyl 4- (trifluoromethoxy) phenyl 401 , 6-dimethylphenyl cyclohexyl 323 , 6 -dimethylphenyl 2 -methylcyclohexyl 337 , 6-dimethylphenyl cycloheptyl 667 , 6 -dimethylphenyl indan-1-yl 357 , 6-dimethylphenyl 2 -dicyclohexyl 406 -phenoxyphenyl phenyl 381 -phenoxyphenyl o-tolyl 395 -phenoxyphenyl 4-chloro-2 -methylphenyl 430 -phenoxyphenyl 2-fluorophenyl 399 -phenoxyphenyl 3-fluorophenyl 399 -phenoxyphenyl 4-fluorophenyl 399 -phenoxyphenyl 2, 4-difluorophenyl 417 -phenoxyphenyl 2 -methoxyphenyl 411 -phenoxyphenyl 3 -methoxyphenyl 411 -phenoxyphenyl 4-methoxyphenyl 411 -phenoxyphenyl 2 , 4-dimethoxyphenyl 441 -phenoxyphenyl 2 -phenoxyphenyl 473 -phenoxyphenyl 3 -phenoxyphenyl 473 -phenoxyphenyl 4-phenoxyphenyl 473 -phenoxyphenyl 4-biphenyl 457 -phenoxyphenyl 4-benzylphenyl 472 -phenoxyphenyl 4- (trifluoromethoxy) phenyl 465 -phenoxyphenyl cyclohexyl 387 -phenoxyphenyl 2 -methylcyclohexyl 401 -phenoxyphenyl cycloheptyl 401 -phenoxyphenyl indan-1-yl 421 -phenoxyphenyl 2-dicyclohexyl 470 phenyl phenyl 289 phenyl o-tolyl 303 phenyl 4-chloro-2-methylphenyl 338 phenyl 2-fluorophenyl 307 phenyl 3 -fluorophenyl 307 phenyl 4- fluorophenyl 307 phenyl 2, 4-difluorophenyl 325 phenyl 2 -methoxyphenyl 319 phenyl 3 -methoxyphenyl 319 phenyl 4-methoxyphenyl 319 phenyl 2 , 4-dimethoxyphenyl 349 phenyl 2 -phenoxyphenyl 381 phenyl 3 -phenoxyphenyl 381 phenyl 4-phenoxyphenyl 381 phenyl 4-biphenyl 365 phenyl 4-benzylphenyl 379 phenyl 4- (trifluoromethoxy) phenyl 373 phenyl cyclohexyl 295 phenyl 2 -methylcyclohexyl 309 phenyl cycloheptyl 309 phenyl indan-1-yl 329 phenyl 2 -dicyclohexyl 377 2 , 4-difluorophenyl phenyl 325 2 , 4-difluorophenyl o-tolyl 339 2 , 4-difluorophenyl 4-chloro-2 -methylphenyl 374 2 , 4-difluorophenyl 2-fluorophenyl 343 2 , 4-difluorophenyl 3-fluorophenyl 343 2 , 4-difluorophenyl 4-fluorophenyl 343 , 4-difluorophenyl 2 , 4-difluorophenyl 361 , 4-difluorophenyl 2-methoxyphenyl 355 , 4-difluorophenyl 3 -methoxyphenyl 355 , 4-difluorophenyl 4-methoxyphenyl 355 , 4-difluorophenyl 2 , 4-dimethoxyphenyl 385 , 4-difluorophenyl 2-phenoxyphenyl 417 , 4-difluorophenyl 3 -phenoxyphenyl 417 , 4-difluorophenyl 4-phenoxyphenyl 417 , 4-difluorophenyl 4-biphenyl 401 , 4-difluorophenyl 4-benzylphenyl 415 , 4-difluorophenyl 4- (trifluoromethoxy) phenyl 409 , 4-difluorophenyl cyclohexyl 331 , 4-difluorophenyl 2-methylcyclohexyl 345 , 4-difluorophenyl cycloheptyl 345 , 4-difluorophenyl indan-1-yl 365 , 4-difluorophenyl 2-dieye1ohexy1 413 , 6-diisopropylphenyl phenyl 373 , 6-diisopropyIphenyl o-tolyl 387 , 6-diisopropyIphenyl 4-chloro-2-methylphenyl 422 , 6-diisopropyIphenyl 2-fluorophenyl 391 , 6-diisopropyIphenyl 3-fluorophenyl 391 , 6-diisopropyIphenyl 4-fluorophenyl 391 , 6-diisopropyIphenyl 2 , 4-difluorophenyl 409 , 6-diisopropyIphenyl 2-methoxyphenyl 403 , 6-diisopropyIphenyl 3 -methoxyphenyl 403 , 6-diisopropyIphenyl 4-methoxyphenyl 403 , 6-diisopropyIphenyl 2 , 4-dimethoxyphenyl 434 , 6-diisopropyIphenyl 2 -phenoxyphenyl 466 , 6-diisopropyIphenyl 3 -phenoxyphenyl 466 , 6-diisopropyIphenyl 4-phenoxyphenyl 466 , 6-diisopropyIphenyl 4-biphenyl 450 , 6-diisopropyIphenyl 4-benzylphenyl 464 , 6-diisopropyIphenyl 4- (trifluoromethoxy) phenyl 457 , 6-diisopropylphenyl cyclohexyl 380 , 6-diisopropyIphenyl 2-methylcyclohexyl 394 , 6-diisopropylphenyl cycloheptyl 394 , 6-diisopropyIphenyl indan-1-yl 414 , 6-diisopropyIphenyl 2-dicyclohexyl 462 , 4-dimethoxyphenyl phenyl 349 , 4-dimethoxyphenyl o-tolyl 363 , 4-dimethoxyphenyl 4-chloro-2-methylphenyl 398 , 4-dimethoxyphenyl 2-fluorophenyl 367 , 4-dimethoxyphenyl 3-fluorophenyl 367 , 4-dimethoxyphenyl 4-fluorophenyl 367 , 4-dimethoxyphenyl 2 , 4-difluorophenyl 385 , 4-dimethoxyphenyl 2-methoxyphenyl 379 , 4-dimethoxyphenyl 3-methoxyphenyl 379 , 4-dimethoxyphenyl 4-methoxyphenyl 379 , 4-dimethoxyphenyl 2 , 4-dimethoxyphenyl 409 , 4-dimethoxyphenyl 2-phenoxyphenyl 441 , 4-dimethoxyphenyl 3-phenoxyphenyl 441 , 4-dimethoxyphenyl 4-phenoxyphenyl 441 , 4-dimethoxyphenyl 4-biphenyl 425 , 4-dimethoxyphenyl 4-benzylphenyl 439 , 4-dimethoxyphenyl 4- (trifluoromethoxy) phenyl 433 , 4-dimethoxyphenyl 3 -trifluoromethylphenyl 417 , 4-dimethoxyphenyl cyclohexyl 355 , 4-dimethoxyphenyl 2-methylcyclohexyl 369 -methoxyphenyl phenyl 319 -methoxyphenyl o-tolyl 333 -methoxyphenyl 4-chloro-2-methylphenyl 368 -methoxyphenyl 2-fluorophenyl 337 -methoxyphenyl 3-fluorophenyl 337 -methoxyphenyl 4-fluorophenyl 337 -methoxyphenyl 2 , 4-difluorophenyl 355 -methoxyphenyl 2-methoxyphenyl 349 -methoxyphenyl 3 -methoxyphenyl 349 -methoxyphenyl 4-methoxyphenyl 349 -methoxyphenyl 2 , 4-dimethoxyphenyl 379 -methoxyphenyl 2-phenoxyphenyl 411 -methoxyphenyl 3-phenoxyphenyl 411 -methoxyphenyl 4-phenoxyphenyl 411 -methoxyphenyl 4-biphenyl 395 -methoxyphenyl 4-benzylphenyl 409 -methoxyphenyl 4- (trifluoromethoxy) phenyl 403 -methoxyphenyl 3 -trifluoromethylphenyl 387 -methoxyphenyl cyclohexyl 625 -methoxyphenyl 2-methylcyclohexyl 339 -methoxyphenyl phenyl 319 -methoxyphenyl o-tolyl 333 -methoxyphenyl 4-chloro-2-methylphenyl 368 -methoxyphenyl 2-fluorophenyl 337 -methoxyphenyl 3-fluorophenyl 337 -methoxyphenyl 4-fluorophenyl 337 -methoxyphenyl 2 , 4-difluorophenyl 355 -methoxyphenyl 2-methoxyphenyl 349 -methoxyphenyl 3 -methoxyphenyl 349 -methoxyphenyl 4-methoxyphenyl 349 -methoxyphenyl 2 , 4-dimethoxyphenyl 379 -methoxyphenyl 2-phenoxyphenyl 411 -methoxyphenyl 3-phenoxyphenyl 411 -methoxyphenyl 4-phenoxyphenyl 411 -methoxyphenyl 4-biphenyl 395 -methoxyphenyl 4-benzylphenyl 409 -methoxyphenyl 4- (trifluoromethoxy) phenyl 403 -methoxyphenyl 3 -trifluoromethylphenyl 387 -methoxyphenyl cyclohexyl 625 -methoxyphenyl 2-methylcyclohexyl 339 -methoxyphenyl phenyl 319 -methoxyphenyl o-tolyl 333 -methoxyphenyl 4-chloro-2-methylphenyl 368 -methoxyphenyl 2-fluorophenyl 337 -methoxyphenyl 3-fluorophenyl 337 -methoxyphenyl 4-fluorophenyl 337 -methoxyphenyl 2 , 4-difluorophenyl 355 -methoxyphenyl 2-methoxyphenyl 349 -methoxyphenyl 3-methoxyphenyl 349 -methoxyphenyl 4-methoxyphenyl 349 -methoxyphenyl 2 , 4-dimethoxyphenyl 379 -methoxyphenyl 2-phenoxyphenyl 411 -methoxyphenyl 3-phenoxyphenyl 411 -methoxyphenyl 4-phenoxyphenyl 411 -methoxyphenyl 4-biphenyl 395 -methoxyphenyl 4-benzylphenyl 409 -methoxyphenyl 4- (trifluoromethoxy) phenyl 403 -methoxyphenyl 3 -trifluoromethylphenyl 387 -methoxyphenyl cyclohexyl 625 -methoxyphenyl 2 -methylcyclohexyl 339 Table 9 MS (m/z) -chlorophenyl phenyl 338 -chlorophenyl o-tolyl 352 -chlorophenyl 4-chloro-2-methylphenyl 386 -chlorophenyl 2-fluorophenyl 356 -chlorophenyl 3-fluorophenyl 356 -chlorophenyl 4-fluorophenyl 356 -chlorophenyl 2 , 4-difluorophenyl 374 -chlorophenyl 2-methoxyphenyl 368 -chlorophenyl 3-methoxyphenyl 368 -chlorophenyl 4-methoxyphenyl 368 -chlorophenyl 2 , 4-dimethoxyphenyl 398 -chlorophenyl 2-phenoxyphenyl 430 -chlorophenyl 3-phenoxyphenyl 430 -chlorophenyl 4-phenoxyphenyl 430 -chlorophenyl 4-biphenyl 414 4-chlorophenyl 4-benzylphenyl 428 4-chlorophenyl 4- (trifluoromethoxy) phenyl 422 4-chlorophenyl cyclohexyl 344 4-chlorophenyl 2-methylcyclohexyl 358 phenyl phenyl 303 phenyl o-tolyl 317 phenyl 4-chloro-2-methylphenyl 352 phenyl 2-fluorophenyl 321 phenyl 3 -fluorophenyl 321 phenyl 4-fluorophenyl 321 phenyl 2 , 4-difluorophenyl 339 phenyl 2-methoxyphenyl 333 phenyl 3 -methoxyphenyl 333 phenyl 4-methoxyphenyl 333 phenyl 2 , 4-dimethoxyphenyl 363 phenyl 2-phenoxyphenyl 395 phenyl 3 -phenoxyphenyl 395 phenyl 4-phenoxyphenyl 395 phenyl 4-biphenyl 379 phenyl 4-benzylphenyl 393 phenyl 4- (trifluoromethoxy) phenyl 387 phenyl 3-trifluoromethylphenyl 371 phenyl cyclohexyl 309 phenyl 2-methylcyclohexyl 323 R J E_ MS (m/z) o-tolyl N-methyIphenyl 317 o-tolyl 4-chloro-N-methyIphenyl 352 o-tolyl N-methylcyclohexyl 323 2-fluorophenyl N-methyIphenyl 321 2-fluorophenyl 4-chloro-N-methylphenyl 356 2-fluorophenyl N-methylcyclohexyl 327 2 , 6-dimethylphenyl N-methylphenyl 331 2 , 6-dimethylphenyl 4-chloro-N-methyIphenyl 366 2 , 6-dimethylphenyl N-methylcyclohexyl 337 2-phenoxyphenyl N-methylphenyl 395 2-phenoxyphenyl 4-chloro-N-methyIphenyl 430 2-phenoxyphenyl N-methylcyclohexyl 401 phenyl N-methylphenyl 303 phenyl 4-chloro-N-methyIphenyl 338 phenyl N-methylcyclohexyl 309 2 , 4-difluorophenyl N-methyIphenyl 339 2 , 4-difluorophenyl 4-chloro-N-methylphenyl 374 2 , 4-difluorophenyl N-methylcyclohexyl 345 2 , 6-diisopropyIphenyl N-methyIphenyl 387 2 , 6-diisopropyIphenyl 4-chloro-N-methyIphenyl 422 2 , 6-diisopropyIphenyl N-methylcyclohexyl 394 , 4-dimethoxyphenyl N-methylphenyl 363 , 4-dimethoxyphenyl 4-chloro-N-methylphenyl 398 , 4-dimethoxyphenyl N-methylcyclohexyl 369 -methoxyphenyl N-methylphenyl 333 -methoxyphenyl 4-chloro-N-methyIphenyl 368 -methoxyphenyl N-methylcyclohexyl 339 -methoxyphenyl N-methylphenyl 333 -methoxyphenyl 4-chloro-N-methyIphenyl 368 -methoxyphenyl N-methylcyclohexyl 339 -methoxyphenyl N-methylphenyl 333 -methoxyphenyl 4-chloro-N-methyIphenyl 368 -methoxyphenyl N-methylcyclohexyl 339 RI E: (m/z) 4-chlorophenyl phenyl 352 4-chlorophenyl 4-chlorophenyl 386 4-chlorophenyl cyclohexyl 358 phenyl phenyl 317 phenyl 4-chlorophenyl 352 phenyl cyclohexyl 323 The compounds listed in Tables 12-13 can be prepared from 6-chloro-N-substituted nicotinamides compounds and the appropriate amine according to the general procedure above . R÷X o-tolyl 3-trifluoromethylphenyl 2-fluorophenyl 3-trifluoromethylphenyl 2 , 6-dimethylphenyl 3 -trifluoromethylphenyl 2 -phenoxyphenyl 3 -trifluoromethylphenyl phenyl 3 -trifluoromethylphenyl 2 , 4-difluorophenyl 3 -trifluoromethylphenyl 2 , 6-diisopropyIphenyl 3-trifluoromethylphenyl 2 , 4-dimethoxyphenyl cycloheptyl 2 , 4-dimethoxyphenyl indan-1-yl 2 , 4-dimethoxyphenyl 2 -dicyclohexyl 3-methoxyphenyl cycloheptyl 3 -methoxyphenyl indan-1-yl 3-methoxyphenyl 2-dicyclohexyl 4-methoxyphenyl cycloheptyl 4-methoxyphenyl indan-1-yl 4-methoxyphenyl 2-dieye1ohexy1 2-methoxyphenyl cycloheptyl 2-methoxyphenyl indan-1-yl 2-methoxyphenyl 2-dieye1ohexy1 Table 13 RX s 4-chlorophenyl 3-trifluoromethylphenyl 4-chlorophenyl cycloheptyl 4-chlorophenyl indan-1-yl 4-chlorophenyl 2-dicyc1ohexy1 phenyl cycloheptyl phenyl indan-1-yl phenyl 2 -dicyc1ohexy1 Example 20 The following assays were used to characterize the ability of compounds of the invention to inhibit the production of TNF-α and IL-l-β. The second assay measured the inhibition of TNF-α and/or IL-l-β in mice after oral administration of the test compounds. The third assay, a glucagon binding inhibition in vitro assay, can be used to characterize the ability of compounds of the invention to inhibit glucagon binding. The fourth assay, a Cyclooxygenase enzyme (COX-1 and COX-2) inhibition activity in vitro assay, can be used to characterize the ability of compounds of the invention to inhibit COX-1 and/or COX-2. The fifth assay, a Raf-kinase inhibition assay, can be used to characterize the compounds of the invention to inhibit phosphorylation of MEK by activated Raf-kinase. Lipopolysaccharide-activated monocyte TNF production assay Isolation of monocytes Test compounds were evaluated in vi tro for the ability to inhibit the production of tumor necrosis factor (TNF) by monocytes activated with bacterial lipopolysaccharide (LPS) . Fresh residual source leukocytes (a byproduct of plateletpheresis) were obtained from a local blood bank, and peripheral blood mononuclear cells (PBMCs) were isolated by density gradient centrifugation on Ficol-Paque Plus (Pharmacia) . PBMCs were suspended at 2 x lOVml in DMEM supplemented to contain 2% FCS, 10 mM, 0.3 mg/ml glutamate, 100 U/ml penicillin G and 100 mg/ml streptomycin sulfate (complete media) . Cells were plated into Falcon flat bottom, 96 well culture plates (200 μl/well) and cultured overnight at 37°C and 6% C0 2 . Non-adherent cells were removed by washing with 200 μl/well of fresh medium. Wells containing adherent cells (-70% monocytes) were replenished with 100 μl of fresh medium. Preparation of test compound stock solutions Test compounds were dissolved in DMSO. Compound stock solutions were prepared to an initial concentration of 10 - 50 μM. Stocks were diluted initially to 20 - 200 μM in complete media. Nine twofold serial dilutions of each compound were then prepared in complete medium. Treatment of cells with test compounds and activation of TNF production with lipopolysaccharide One hundred microliters of each test compound dilution were added to microtiter wells containing adherent monocytes and 100 μl complete medium. Monocytes were cultured with test compounds for 60 in at which time 25 μl of complete medium containing 30 ng/ml lipopolysaccharide from E. coli K532 were added to each well. Cells were cultured an additional 4 hrs. Culture supernatants were then removed and TNF presence in the supernatants was quantified using an ELISA. TNF ELISA Flat bottom, 96 well Corning High Binding ELISA plates were coated overnight (4°C) with 150 μL/well of 3 μg/ml murine anti-human TNF-α MAb (R&D Systems #MAB210) . Wells were then blocked for 1 hr at room temperature with 200 μL/well of CaCl 2 -free ELISA buffer supplemented to contain 20 mg/ml BSA (standard ELISA buffer: 20 mM, 150 mM NaCl, 2 mM CaCl 2 , 0.15 mM thimerosal, pH 7.4). Plates were washed and replenished with 100 μl of test supernatants (diluted 1:3) or standards. Standards consisted of eleven 1.5-fold serial dilutions from a stock of 1 ng/ml recombinant human TNF (R&D Systems) . Plates were incubated at room temperature for 1 hr on orbital shaker (300 rpm) , washed and replenished with 100 μl/well of 0.5 μg/ml goat anti-human TNF-α (R&D systems #AB-210-NA) biotinylated at a 4:1 ratio. Plates were incubated for 40 in, washed and replenished with 100 μl/well of alkaline phosphatase-conjugated streptavidin (Jackson ImmunoResearcn #016-050-084) at 0.02 μg/ml. Plates were incubated 30 min, washed and replenished with 200 μl/well of 1 mg/ml of p-nitrophenyl phosphate. After 30 min, plates were read at 405 nm on a V max plate reader. Data analysis Standard curve data were fit to a second order polynomial and unknown TNF-α concentrations determined from their OD by solving this equation for concentration. TNF concentrations were then plotted vs. test compound concentration using a second order polynomial. This equation was then used to calculate the concentration of test compounds causing a 50% reduction in TNF production. The following compounds had an IC 50 of less than 15 μM: 2-cyclohexyloxy-5- ( 2-chlorophenylcarbonylamino ) pyridine ; 2 -cyclohexyloxy-5- (2 -methylphenylcarbonylamino ) pyridine; 2-cyclohexyloxy-5- (2, 6-dichlorophenylcarbonylamino) pyridine; 2-cyclohexyloxy-5- (2, 6-dimethylphenylcarbonylamino) pyridine; 2- (2, 4-dimethylphenoxy) -5- (2-methylphenylcarbonylamino) pyridine; 2- ( 2-methyl-4-fluorophenoxy) -5- (2-methylphenylcarbonyl amino) pyridine; 2- (2-methyl-4-chlorophenoxy) -5- (2-chlorophenylcarbonyl amino ) pyridine ; 2- (2-methyl-4-chlorophenoxy) -5- (2 , 6-dichlorophenyl carbonylamino) pyridine; 2- (2-methyl-4-chlorophenoxy) -5- (2, 6-dimethylphenyl carbonylamino) pyridine ; 2- (4-chlorophenoxy) -5- (2, 6-dimethylphenylcarbonylamino) pyridine; 2- (2-methyl-4-fluorophenoxy) -5- (2, 6-dichlorophenyl carbonylamino) pyridine; 2- (2-methyl-4-fluorophenoxy) -5- (2, 6-dimethylphenyl carbonylamino) pyridine; 2- (2-methyl-4-fluorophenoxy) -5- (2-fluorophenylcarbonyl amino) pyridine ; 2- (2 , 4-dimethylphenoxy) -5- (2, 6-dimethylphenylcarbonyl amino) pyridine ; 2- (1-naphthyloxy) -5- (2-methylphenylcarbonylamino) pyridine; 2- (1-naphthyloxy) -5- (2, 6-dichlorophenylcarbonylamino) pyridine; 2- (2-methyl-3-pyridyloxy) -5- (2, 6-dichlorophenylcarbonyl amino) pyridine ; 2- (2-methyl-4-chlorophenoxy) -5- ( (3 , 5-dimethyl-4- isoxazolyl) carbonylamino) pyridine ,• 2-cyclohexylamino-5- (2 , 6-dichlorophenylcarbonylamino) pyridine; 2-cyclohexylamino.-5- (2, 6-dimethylphenylcarbonylamino) pyridine; 2- (2-methylcyclohexylamino) -5- (2 , 6- dichlorophenylcarbonyl amino) pyridine; 2- (2-methylcyclohexylamino) -5- (2-methylphenylcarbonyl amino) pyridine; 2- (2-methylphenylamino) -5- (2-methyIphenylcarbonyl amino) pyridine ; 2- (2-methylphenylamino) -5- (2, 6-dimethylphenylcarbonyl amino ) pyridine ; 2- (2-methyl-4-chlorophenylamino) -5- (2-methylphenyl carbonylamino) pyridine; and 2- (2-methyl-4-chlorophenylamino) -5- (2-methylphenyl aminocarbonyl) pyridine . Compounds of the invention can also be shown to inhibit LPS-induced release of IL-lβ, IL-6 and/or IL-8 from monocytes by measuring concentrations of IL-lβ, IL- 6 and/or IL-8 by methods well known to those skilled in the art. In a similar manner to the above described assay involving the LPS induced release of TNF-α from monocytes, compounds of this invention can also be shown to inhibit LPS induced release of IL-lβ, IL-6 and/or IL- 8 from monocytes by measuring concentrations of IL-lβ, IL-6 and/or IL-8 by methods well known to those skilled in the art. Thus, the compounds of the invention may lower elevated levels of TNF-α, IL-1, IL-6, and IL-8 levels. Reducing elevated levels of these inflammatory cytokines to basal levels or below is favorable in controlling, slowing progression, and alleviating many disease states. All of the compounds are useful in the methods of treating disease states in which TNF-α, IL- lβ, IL-6, and IL-8 play a role to the full extent of the definition of TNF-α-mediated diseases described herein. Inhibition of LPS-Induced TNF-α production in mice Male DBA/lLACJ mice are dosed with vehicle or test compounds in a vehicle (the vehicle consisting of 0.5% tragacanth in 0.03 N HCl) 30 minutes prior to lipopolysaccharide (2 mg/kg, I.V.) injection. Ninety minutes after LPS injection, blood are collected and the serum is analyzed by ELISA for TNF levels. Selected compounds from the class have shown in vivo activity in a LPS mouse model in which serum levels of TNF-α were reduced in the presence of compounds of this invention. Compounds of the invention may be shown to have anti-inflammatory properties in animal models of inflammation, including carageenan paw edema, collagen induced arthritis and adjuvant arthritis, such as the carageenan paw edema model (C. A. Winter et al Proc. Soc. Exp. Biol. Med. (1962) vol 111, p 544; K. F. Swingle, in R. A. Scherrer and M. W. Whitehouse, Eds., Antiinflammatory Agents, Chemistry and Pharmacology, Vol. 13-11, Academic, New York, 1974, p. 33) and collagen induced arthritis (D. E. Trentham et al J. Exp. Med. (1977) vol. 146, p 857; J. S. Courtenay, Nature (New Biol.) (1980), Vol 283, p 666). 125 I-Glucagon Binding Screen with CHO/hGLUR Cells The assay is described in WO 97/16442, which is incorporated herein by reference in its entirety. Reagents The reagents can be prepared as follows: (a) prepare fresh IM o-Phenanthroline (Aldrich) (198.2 mg/ml ethanol); (b) prepare fresh 0.5M DTT (Sigma); (c) Protease Inhibitor Mix (1000X) : 5 mg leupeptin, 10 mg benzamidine, 40 mg bacitracin and 5 mg soybean trypsin inhibitor per ml DMSO and store aliquots at -20°C; (d) 250 μM human glucagon (Peninsula): solubilize 0.5 mg vial in 575 μl 0. IN acetic acid (1 μl yields 1 μM final concentration in assay for non-specific binding) and store in aliquots at -20°C; (e) Assay Buffer: 20mM Tris (pH 7.8), 1 mM DTT and 3 mM o-phenanthroline; (f) Assay Buffer with 0.1% BSA (for dilution of label only; 0.01% final in assay) : 10 μl 10% BSA (heat-inactivated) and 990 μl Assay Buffer; (g) l5 I-Glucagon (NEN, receptor- grade, 2200 Ci/mmol) : dilute to 50,000 cpm/25 μl in assay buffer with BSA (about 50pM final concentration in assay) . Harvesting of CHO/hGLUR Cells for Assay 1. Remove media from confluent flask then rinse once each with PBS (Ca, Mg-free) and Enzyme-free Dissociation Fluid (Specialty Media, Inc.). 2. Add 10 ml Enzyme-free Dissoc. Fluid and hold for about 4 min. at 37°C. 3. Gently tap cells free, triturate, take aliquot for counting and centrifuge remainder for 5 min. at 1000 rpm. 4. Resuspend pellet in Assay Buffer at 75000 cells per 100 μl . Membrane preparations of CHO/hGLUR cells can be used in place of whole cells at the same assay volume. Final protein concentration of a membrane preparation is determined on a per batch basis. Assay The determination of inhibition of glucagon binding can be carried out by measuring the reduction of I 1 - glucagon binding in the presence of compounds of Formula I. The reagents are combined in 120 μL of assay buffer as follows: Compound/ 125_- 250 μM CHO/hGLUR Vehicle Glucagon Glucagon Cells Total — /5 μl -- 25 μl 100 μl Binding + 5 μl/-- -- 25 μl 100 μl Compound Nonspecif —/5 μl 1 μl 25 μl 100 μl ic Binding The mixture is incubated for 60 min. at 22°C on a shaker at 275 rpm. The mixture is filtered over pre-soaked (0.5% polyethylimine (PEI) ) GF/C filtermat using an Innotech Harvester or Tomtec Harvester with four washes of ice-cold 20mM Tris buffer (pH 7.8). The radioactivity in the filters is determined by a gamma- scintillation counter. Thus, compounds of the invention may also be shown to inhibit the binding of glucagon to glucagon receptors . Cyclooxygenase Enzyme Activity Assay The human monocytic leukemia cell line, THP-1, differentiated by exposure to phorbol esters expresses only COX-1; the human osteosarcoma cell line 143B expresses predominantly COX-2. THP-1 cells are routinely cultured in RPMI complete media supplemented with 10% FBS and human osteosarcoma cells (HOSC) are cultured in minimal essential media supplemented with 10% fetal bovine serum (MEM-10%FBS) ; all cell incubations are at 37°C in a humidified environment containing 5% C0 2 . COX-1 Assay In preparation for the COX-1 assay, THP-1 cells are grown to confluency, split 1:3 into RPMI containing 2% FBS and 10 mM phorbol 12-myristate 13-acetate (TPA) , and incubated for 48 hours on a shaker to prevent attachment. Cells are pelleted and resuspended in Hank's Buffered Saline (HBS) at a concentration of 2.5 x 10° cells/mL and plated in 96-well culture plates at a density of 5 x 10 5 cells/mL. Test compounds are diluted in HBS and added to the desired final concentration and the cells are incubated for an additional 4 hours. Arachidonic acid is added to a final concentration of 30 mM, the cells incubated for 20 minutes at 37°C, and enzyme activity determined as described below. COX-2 Assay For the COX-2 assay, subconfluent HOSC are trypsinized and resuspended at 3 x 10 6 cells/mL in MEM- FBS containing 1 ng human IL-lb/mL, plated in 96-well tissue culture plates at a density of 3 x 10 4 cells per well, incubated on a shaker for 1 hour to evenly distribute cells, followed by an additional 2 hour static incubation to allow attachment. The media is then replaced with MEM containing 2% FBS (MEM-2%FBS) and 1 ng human IL-lb/mL, and the cells incubated for 18-22 hours. Following replacement of media with 190 mL MEM, 10 mL of test compound diluted in HBS is added to achieve the desired concentration and the cells incubated for 4 hours . The supernatants are removed and replaced with MEM containing 30 mM arachidonic acid, the cells incubated for 20 minutes at 37°C, and enzyme activity determined as described below. COX Activity Determined After incubation with arachidonic acid, the reactions are stopped by the addition of 1 N HCl, followed by neutralization with 1 N NaOH and centrifugation to pellet cell debris. Cyclooxygenase enzyme activity in both HOSC and THP-1 cell supernatants is determined by measuring the concentration of PGE 2 using a commercially available ELISA (Neogen #404110) . A standard curve of PGE 2 is used for calibration, and commercially available COX-1 and COX-2 inhibitors are included as standard controls. The following compound exhibits activities in the Cyclooxygenase assay with IC 50 values of 10 μM or less: 2- (2 , 4-dimethyIphenylamino) -5- (2 , 6- dichlorophenylcarbonyl amino)pyridine . Raf Kinase assay In vi tro Raf kinase activity is measured by the extent of phosphorylation of the substrate MEK (Map kinase/ERK kinase) by activated Raf kinase. Phosphorylated MEK is trapped on a filter and incorporation of radiolabeled phosphate is quantified by scintillation counting. MATERIALS : Activated Raf is produced by triple transfection of Sf9 cells with baculoviruses expressing "Glu-Glu" -epitope tagged Raf , val 12 -H-Ras , and Lck. The "Glu-Glu" -epitope, Glu-Try-Met-Pro-Met-Glu, was fused to the carboxy- terminus of full length c-Raf. Catalvticallv inactive MEK (K97A mutation) is produced in Sf9 cells transfected with a baculovirus expressing c-terminus "Glu-Glu" epitope-tagged K97A MEK1. Anti "Glu-Glu" antibody was purified from cells grown as described in: Grussenmeyer, et al . , Proceedings of the National Academy of Science, U.S.A. pp 7952-7954, 1985. Column buffer: 20 mM Tris pH=8, 100 mM NaCl, 1 mM EDTA, 2.5 mM EGTA, 10 mM MgCl 2 , 2 mM DTT, 0.4 mM AEBSF, 0.1% n-octylglucopyranoside, 1 nM okadeic acid, and 10 μg/mL each of benzamidine, leupeptin, pepstatin, and aprotinin. 5x Reaction buffer: 125 mM HEPES pH=8, 25 mM MgCl 2 , 5 mM EDTA, 5 mM Na 3 V0 4 , 100 μg/mL BSA. Enzvme dilution buffer: 25 mM HEPES pH=8, 1 mM EDTA, 1 mM Na 3 V0 4 , 400 μg/mL BSA. Stop solution: 100 mM EDTA, 80 mM sodium pyrophosphate. Filter plates : Milipore multiscreen # SE3M078E3, Immobilon-P (PVDF) . METHODS : Protein purification: Sf9 cells were infected with baculovirus and grown as described in Williams, et al . , Proceedings of the National Academy of Science, U.S.A. pp 2922-2926, 1992. All subsequent steps were preformed on ice or at 4 °C. Cells were pelleted and lysed by sonication in column buffer. Lysates were spun at 17,000xg for 20 min, followed by 0.22 μm filtration. Epitope tagged proteins were purified by chromatography over GammaBind Plus affinity column to which the "Glu- Glu" antibody was coupled. Proteins were loaded on the column followed by sequential washes with two column volumes of column buffer, and eluted with 50 μg/mL Glu- Tyr-Met-Pro-Met-Glu in column buffer. Raf kinase assay: Test compounds were evaluated using ten 3-fold serial dilutions starting at 10 - 100 uM. 10 μL of the test inhibitor or control, dissolved in 10% DMSO, was added to the assay plate followed by the addition of 30 μL of the a mixture containing 10 μL 5x reaction buffer, ImM 33 P-γ-ATP (20 μCi/mL) , 0.5 μL MEK (2.5 mg/mL) , 1 μL 50 mM β-mercaptoethanol . The reaction was started by the addition of 10 μL of enzyme dilution buffer containing 1 mM DTT and an amount of activated Raf that produces linear kinetics over the reaction time course. The reaction was mixed and incubated at room temperature for 90 min. and stopped by the addition of 50 μL stop solution. 90 μL aliquots of this stopped solution were transferred onto GFP-30 cellulose microtiter filter plates (Polyfiltronics) , the filter plates washed in four well volumes of 5% phosphoric acid, allowed to dry, and then replenished with 25 μl scintillation cocktail. The plates were counted for 33p gamma emission using a TopCount Scintillation Reader. Accordingly, the compounds of the invention or a pharmaceutical composition thereof are useful for prophylaxis and treatment of rheumatoid arthritis; Pagets disease; osteophorosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; pancreatic β cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS) ; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; asthma; muscle degeneration; cachexia; Reiter's syndrome; type I and type II diabetes; bone resorption diseases; graft vs. host reaction; ischemia reperfusion injury; atherosclerosis; brain trauma; Alzheimer's disease; stroke; myocardial infarction; multiple sclerosis; cerebral malaria; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection. HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV) , influenza, adenovirus, the herpes viruses (including HSV-1, HSV-2) , and herpes zoster, all of which are sensitive to TNF-α and/or IL-1 inhibition or glucagon antagonism, will also be positively effected by the compounds and methods of the invention. The compounds of the present invention may also possess oncolytic characteristics and may be useful for the treatment of cancer. The compounds of the present invention may also block signal transduction by extracellular mitogenic stimuli and oncoproteins through inhibition of Raf kinase. The compounds of the present invention also may possess analgesic properties and may be useful for the treatment of pain disorders, such as hyperalgesia due to excessive IL-1. The compounds of the present invention may also prevent the production of prostaglandins by inhibition of enzymes in the human arachidonic acid/prostaglandin pathway, including cyclooxygenase (WO 96/03387, incorporated herein by reference in its entirety) . Because of their ability to lower TNF-α and IL-1 concentrations or inhibit glucagon binding to its receptor, the compounds of the invention are also useful research tools for studying the physiology associated with blocking these effects. The methods of the invention comprise administering an effective dose of a compound of the invention, a pharmaceutical salt thereof, or a pharmaceutical composition of either, to a subject (i.e., an animal, preferably a mammal, most preferably a human) in need of a reduction in the level of TNF-α, IL-1, IL-6, and/or IL-8 levels and/or reduction in plasma glucose levels and/or which subject may be suffering from rheumatoid arthritis; Pagets disease; osteophorosis ; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; pancreatic β cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS) ; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; asthma; muscle degeneration; cachexia; Reiter's syndrome; type I and type II diabetes; cancer; bone resorption diseases; graft vs. host reaction; Alzheimer's disease; stroke; myocardial infarction; ischemia reperfusion injury; atherosclerosis; brain trauma; multiple sclerosis; cerebral malaria; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection, or which subject is infected by HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV) , influenza, adenovirus, the herpes viruses (including HSV-1, HSV-2), or herpes zoster. In another aspect, this invention comprises the use of a compound of the invention, or pharmaceutically acceptable salts thereof, in the manufacture of a medicament for the treatment either acutely or chronically of a TNF-α, IL-lβ, IL-6, and/or IL-8 mediated disease state, including those described previously. The compounds of the present are also useful in the manufacture of an anti-cancer medicant. The compounds of the present invention are also useful in the manufacture of a medicant to attenuate or prevent signal transduction by extracellular mitogenic stimuli and oncoproteins through inhibition of Raf kinase. Also, the compounds of this invention are useful in the manufacture of a analgesic medicament and a medicament for treating pain disorders, such as hyperalgesia. The compounds of the present invention also are useful in the manufacture of a medicament to prevent the production of prostaglandins by inhibition of enzymes in the human arachidonic acid/prostaglandin pathway. In still another aspect, this invention provides a pharmaceutical composition comprising an effective TNF- α, IL-lβ, IL-6, and/or IL-8 lowering amount and/or effective plasma glucose level lowering amount, and/or effective tumor supressing amount of a compound of the invention and a pharmaceutically acceptable carrier or diluent, and if desired other active ingredients. The compounds of the invention are administered by any suitable route, preferably in the form of a pharmaceutical composition adapted to such a route, and in a dose effective for the treatment intended. Therapeutically effective doses of the compounds of the present invention required to arrest the progress or prevent tissue damage associated with the disease are readily ascertained by one of ordinary skill in the art using standard methods. For the treatment of TNF-α, IL-lβ, IL-6, and IL-8 mediated diseases, cancer, and/or hyperglycemia, the compounds of the present invention may be administered orally, parentally, by inhalation spray, rectally, or topically in dosage unit formulations containing conventional pharmaceutically acceptable carriers, adjuvants, and vehicles. The term parenteral as used herein includes, subcutaneous, intravenous, intramuscular, intrasternal, infusion techniques or intraperitoneally. The dosage regimen for treating a TNF-α, IL-1, IL- 6, and IL-8 mediated diseases, cancer, and/or hyperglycemia with the compounds of this invention and/or compositions of this invention is based on a variety of factors, including the type of disease, the age, weight, sex, medical condition of the patient, the severity of the condition, the route of administration, and the particular compound employed. Thus, the dosage regimen may vary widely, but can be determined routinely using standard methods. Dosage levels of the order from about 0.01 mg to 30 mg per kilogram of body weight per day, preferably from about 0.1 mg to 10 mg/kg, more preferably from about 0.25 mg to 1 mg/kg are useful for all methods of use disclosed herein. The pharmaceutically active compounds of this invention can be processed in accordance with conventional methods of pharmacy to produce medicinal agents for administration to patients, including humans and other mammals . For oral administration, the pharmaceutical composition may be in the form of, for example, a capsule, a tablet, a suspension, or liquid. The pharmaceutical composition is preferably made in the form of a dosage unit containing a given amount of the active ingredient. For example, these may contain an amount of active ingredient from about 1 to 2000 mg, preferably from about 1 to 500 mg, more preferably from about 5 to 150 mg. A suitable daily dose for a human or other mammal may vary widely depending on the condition of the patient and other factors, but, once again, can be determined using routine methods. The active ingredient may also be administered by injection as a composition with suitable carriers including saline, dextrose, or water. The daily parenteral dosage regimen will be from about 0.1 to about 30 mg/kg of total body weight, preferably from about 0.1 to about 10 mg/kg, and more preferably from about 0.25 mg to 1 mg/kg. Injectable preparations, such as sterile injectable aqueous or oleaginous suspensions, may be formulated according to the known are using suitable dispersing or wetting agents and suspending agents. The sterile injectable preparation may also be a sterile injectable solution or suspension in a non-toxic parenterally acceptable diluent or solvent, for example as a solution in 1, 3-butanediol . Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution, and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil may be employed, including synthetic mono- or diglycerides . In addition, fatty acids such as oleic acid find use in the preparation of injectables . Suppositories for rectal administration of the drug can be prepared by mixing the drug with a suitable non- irritating excipient such as cocoa butter and polyethylene glycols that are solid at ordinary temperatures but liquid at the rectal temperature and will therefore melt in the rectum and release the drug. A suitable topical dose of active ingredient of a compound of the invention is 0.1 mg to 150 mg administered one to four, preferably one or two times daily. For topical administration, the active ingredient may comprise from 0.001% to 10% w/w, e.g., from 1% to 2% by weight of the formulation, although it may comprise as much as 10% w/w, but preferably not more than 5% w/w, and more preferably from 0.1% to 1% of the formulation. Formulations suitable for topical administration include liquid or semi-liquid preparations suitable for penetration through the skin (e.g., liniments, lotions, ointments, creams, or pastes) and drops suitable for administration to the eye, ear, or nose. For administration, the compounds of this invention are ordinarily combined with one or more adjuvants appropriate for the indicated route of administration. The compounds may be admixed with lactose, sucrose, starch powder, cellulose esters of alkanoic acids, stearic acid, talc, magnesium stearate, magnesium oxide, sodium and calcium salts of phosphoric and sulphuric acids, acacia, gelatin, sodium alginate, polyvinylpyrrolidine, and/or polyvinyl alcohol, and tableted or encapsulated for conventional administration. Alternatively, the compounds of this invention may be dissolved in saline, water, polyethylene glycol, propylene glycol, ethanol, corn oil, peanut oil, cottonseed oil, sesame oil, tragacanth gum, and/or various buffers. Other adjuvants and modes of administration are well known in the pharmaceutical art. The carrier or diluent may include time delay material, such as glyceryl monostearate or glyceryl distearate alone or with a wax, or other materials well known in the art . The pharmaceutical compositions may be made up in a solid form (including granules, powders or suppositories) or in a liquid form (e.g., solutions, suspensions, or emulsions). The pharmaceutical compositions may be subjected to conventional pharmaceutical operations such as sterilization and/or may contain conventional adjuvants, such as preservatives, stabilizers, wetting agents, emulsifiers, buffers etc. Solid dosage forms for oral administration may include capsules, tablets, pills, powders, and granules. In such solid dosage forms, the active compound may be admixed with at least one inert diluent such as sucrose, lactose, or starch. Such dosage forms may also comprise, as in normal practice, additional substances other than inert diluents, e.g., lubricating agents such as magnesium stearate. In the case of capsules, tablets, and pills, the dosage forms may also comprise buffering agents. Tablets and pills can additionally be prepared with enteric coatings. Liquid dosage forms for oral administration may include pharmaceutically acceptable emulsions, solutions, suspensions, syrups, and elixirs containing inert diluents commonly used in the art, such as water. Such compositions may also comprise adjuvants, such as wetting, sweetening, flavoring, and perfuming agents. Compounds of the present invention can possess one or more asymmetric carbon atoms and are thus capable of existing in the form of optical isomers as well as in the form of racemic or non-racemic mixtures thereof. The optical isomers can be obtained by resolution of the racemic mixtures according to conventional processes, e.g., by formation of diastereoisomeric salts, by treatment with an optically active acid or base. Examples of appropriate acids are tartaric, diacetyltartaric, dibenzoyltartaric, ditoluoyltartaric, and camphorsulfonic acid and then separation of the mixture of diastereoisomers by crystallization followed by liberation of the optically active bases from these salts. A different process for separation of optical isomers involves the use of a chiral chromatography column optimally chosen to maximize the separation of the enantiomers . Still another available method involves synthesis of covalent diastereoisomeric molecules by reacting compounds of the invention with an optically pure acid in an activated form or an optically pure isocyanate. The synthesized diastereoisomers can be separated by conventional means such as chromatography, distillation, crystallization or sublimation, and then hydrolyzed to deliver the enantiomerically pure compound. The optically active compounds of the invention can likewise be obtained by using active starting materials. These isomers may be in the form of a free acid, a free base, an ester or a salt. The compounds of the present invention can be used in the form of salts derived from inorganic or organic acids. The salts include, but are not limited to, the following: acetate, adipate, alginate, citrate, aspartate, benzoate, benzenesulfonate, bisulfate, butyrate, camphorate, camphorsulfonate, digluconate, cyclopentanepropionate, dodecylsulfate, ethanesulfonate, glucoheptanoate, glycerophosphate, hemisulfate, heptanoate, hexanoate, fumarate, hydrochloride, hydrobromide, hydroiodide, 2-hyroxy-ethanesulfonate, lactate, maleate, methansulfonate, nicotinate, 2- naphthalenesulfonate, oxalate, palmoate, pectinate, persulfate, 2-phenylpropionate, picrate, pivalate, propionate, succinate, tartrate, thiocyanate, tosylate, mesylate, and undecanoate. Also, the basic nitrogen- containing groups can be quaternized with such agents as lower alkyl halides, such as methyl, ethyl, propyl, and butyl chloride, bromides and iodides; dialkyl sulfates like dimethyl, diethyl, dibutyl, and diamyl sulfates, long chain halides such as decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides, aralkyl halides like benzyl and phenethyl bromides, and others. Water or oil-soluble or dispersible products are thereby obtained. Examples of acids that may be employed to from pharmaceutically acceptable acid addition salts include such inorganic acids as hydrochloric acid, sulphuric acid and phosphoric acid and such organic acids as oxalic acid, maleic acid, succinic acid and citric acid. Other examples include salts with alkali metals or alkaline earth metals, such as sodium, potassium, calcium or magnesium or with organic bases. While the compounds of the invention can be administered as the sole active pharmaceutical agent, they can also be used in combination with one or more compounds of the invention or other agents . When administered as a combination, the therapeutic agents can be formulated as separate compositions that are given at the same time or different times, or the therapeutic agents can be given as a single composition. The foregoing is merely illustrative of the invention and is not intended to limit the invention to the disclosed compounds. Variations and changes which are obvious to one skilled in the art are intended to be within the scope and nature of the invention which are defined in the appended claims. From the foregoing description, one skilled in the art can easily ascertain the essential characteristics of this invention, and without departing from the spirit and scope thereof, can make various changes and modifications of the invention to adapt it to various usages and conditions.

Claims: WHAT I S CLAIMED I S : 1. A compound of the formula or a pharmaceutically acceptable salt thereof, wherein X is 0, S, S(O) , S(O), or NR Y is [0)-NR R 4 or -NR -C(0)-R R is a cycloalkyl, aryl, heterocyclyl or heteroaryl radical which is optionally substituted by 1-4 radicals of alkyl, halo, haloalkyl, cyano, azido, nitro, amidino, 18 Ifi _R Ifi R -Z - or R -Z -alkyl; provided that the total number of aryl, heteroaryl, cycloalkyl and heterocyclyl radicals m R 1 i.s 1-3; and provided when Y is -NR -C(O)- 3 1 R and X is 0 or S, R is other than a 2-pyrimidinyl radical ; R is a hydrogen or alkyl radical; R is an aryl or heteroaryl radical which is optionally substituted by 1-5 radicals of alkyl, halo, haloalkyl, 19 19 19 19 cyano, azido, nitro, amidino, R -Z - or R -Z -alkyl; provided that the total number of aryl and heteroaryl radicals in R is 1-3; and provided when Y is -C(O)- 3 4 3 NR R , R is other than a phenyl or naphthyl having a amino, nitro, cyano, carboxy or alkoxycarbonyl substituent bonded to the ring carbon atom adjacent to 4 the ring carbon atom bonded to -NR - ; and 4 R is a hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl " , heteroaryl, arylalkyl, 20 20 heteroarylalkyl or R -Z -alkyl radical; 18 19 20 wherein R , R and R are each independently a hydrogen, alkyl, haloalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl radical; wherein the aryl and 4 18 19 20 heteroaryl radicals of R , R , R and R are optionally substituted by 1-3 radicals of hydroxy, alkoxy, alkylthiol, amino, alkylamino, dialkylamino, alkanoylamino, alkylsulfonylamino, alkylsulfinyl, alkylsulfonyl, alkoxycarbonylamino, alkoxycarbonyl, cyano, halo, azido, alkyl, haloalkyl or haloalkoxy; and 18 19 20 Z , Z and Z are each independently -0-, -S-, -S(0)-, -S(0) 2 -, -C0 2 -, -C(O)-, -NR 21 -, -NR 21 -C(0)-, -C(0)-NR 21 -, - NR -S(0) 2 - or -S(0) 2 -NR - ; wherein each R is independently a hydrogen or alkyl radical; 5 6 R and R are each independently a hydrogen, alkyl, halo, haloalkyl, haloalkoxy, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, amino, alkylamino, dialkylamino, alkanoylamino, alkylsulfonylamino, aminosulfonyl, alkylaminosulfonyl, dialkylammosulfonyl, hydroxy, hydroxyalkyl, thiol, alkylthiol, alkylsulfinyl, alkylsulfonyl, alkoxy, alkoxyalkyl, cyano, azido, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl radical; and η R is a hydrogen, alkyl, halo, haloalkyl, haloalkoxy, aminoalkyl , alkylaminoalkyl , dialkylaminoalkyl , aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl , hydroxy, hydroxyalkyl, thiol, alkylthiol, alkylsulfinyl , alkylsulfonyl, alkoxy, alkoxyalkyl, cyano, azido, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl radical . 2. The compound of Claim 1 or a pharmaceutically acceptable salt thereof, wherein R is a cycloalkyl, aryl, heterocyclyl or heteroaryl radical which is optionally substituted by 1-4 radicals of Cχ-C 6 alkyl, halo, C -C6 haloalkyl of 1-3 halo radicals, cyano, azido, nitro, amidino, R -Z - or R - 18 Z -Cχ-C δ alkyl; provided that the total number of aryl, heteroaryl, cycloalkyl and heterocyclyl radicals in R 4 3 is 1-3; and provided when Y is -NR -C(0)-R and X is 0 or S, R is other than a 2-pyrimidinyl radical; 2 R is a hydrogen or C -C 4 alkyl radical; R is an aryl or heteroaryl radical which is optionally substituted by 1-5 radicals of Ci-Cβ alkyl, halo, Cχ-C6 haloalkyl of 1-3 halo radicals, cyano, azido, nitro, amidino, R -Z - or R -Z -C -C 6 alkyl; provided that the total number of aryl and heteroaryl radicals in R is 1- 3 4 3 . 3; and provided when Y is -C(0)-NRR , R is other than a phenyl or naphthyl having an amino, nitro, cyano, carboxy or alkoxycarbonyl substituent bonded to the ring carbon atom adjacent to the ring carbon atom bonded to - NR - ; and 4 R is a radical of hydrogen, Cχ-C 6 alkyl, C 2 -C 6 alkenyl, C -C 6 haloalkyl of 1-3 halo radicals, C 2 -C 6 haloalkenyl of 1-3 halo radicals, aryl, heteroaryl, aryl-Cχ-C 4 20 20 alkyl, heteroaryl-Cχ-C 4 alkyl or R -Z -Cx-Cβ alkyl radical; and 18 19 20 wherein R , R and R are each independently a hydrogen, C -C 4 alkyl, Cχ-C 4 haloalkyl of 1-3 halo radicals, aryl, heteroaryl, aryl-Cχ-C 4 alkyl or heteroaryl-Cχ-C 4 alkyl radical; wherein the aryl and 4 18 19 20 . heteroaryl radicals of R , R , R and R are optionally substituted by 1-3 radicals of hydroxy, C -C 4 alkoxy, Cχ-C 4 alkylthiol, amino, C -C 4 alkylamino, di (Cχ-C 4 alkyl) amino, Cχ-Cs alkanoylamino, C -C 4 alkylsulfonylamino, C -C 4 alkylsulfinyl, Cχ-C 4 alkylsulfonyl, (Cχ-C 4 alkoxy) carbonylamino, (Cχ-C 4 alkoxy) carbonyl, cyano, halo, azido, C -C 4 alkyl, C -C 4 haloalkyl of 1-3 halo radicals or Cχ-C 4 haloalkoxy of 1- 3 halo radicals; and 21 each R is independently a hydrogen or Cχ-C 4 alkyl radical ; R and R are each independently a hydrogen, C -C 4 alkyl, halo, C -C 4 haloalkyl of 1-3 halo radicals, Cχ-C 4 haloalkoxy of 1-3 halo radicals, C -C 4 aminoalkyl, (C -C 4 alkyl )amino-Cχ-C 4 alkyl, di (Cχ-C 4 alkyl) amino-Cχ-C4 alkyl, amino, Cχ-C 4 alkylamino, di(Cχ-C 4 alkyl) amino, Cχ~ C 5 alkanoylamino, Cχ-C 4 alkylsulfonylamino, aminosulfonyl, Cχ-C 4 alkylaminosulfonyl, di (C -C 4 alkyl) aminosulfonyl, hydroxy, C -C 4 hydroxyalkyl, thiol, C -C 4 alkylthiol, Cχ-C 4 alkylsulfinyl , Cχ-C 4 alkylsulfonyl, C -C 4 alkoxy, (Cχ-C 4 alkoxy) Cχ-C 4 alkyl, cyano, azido, nitro, carboxy, (Cχ-C 4 alkoxy) carbonyl , aminocarbonyl, (Cχ-C 4 alkyl ) aminocarbonyl or di(Cχ-C 4 alkyl ) aminocarbonyl radical; and 7 R is a hydrogen, -Cχ-C 4 alkyl, halo, C -C 4 haloalkyl of 1-3 halo radicals, Cχ-C 4 haloalkoxy of 1-3 halo radicals, Cχ-C 4 aminoalkyl, (Cχ-C 4 alkyl) amino-Cχ-C 4 alkyl, di(Cχ-C 4 alkyl) amino-Cχ-C 4 alkyl, aminosulfonyl, Cχ-C 4 alkylaminosulfonyl, di(Cχ-C 4 alkyl) aminosulfonyl , hydroxy, Cχ-C 4 hydroxyalkyl, thiol, Cχ-C 4 alkylthiol, Cχ~ C 4 alkylsulfinyl, Cχ-C 4 alkylsulfonyl, C -C 4 alkoxy, (Cχ~ C 4 alkoxy) Cχ-C 4 alkyl, cyano, azido, nitro, carboxy, (0- C 4 alkoxy) carbonyl , aminocarbonyl, (Cχ-C 4 alkyl ) aminocarbonyl or di(Cχ-C 4 alkyl ) aminocarbonyl radical; and wherein cycloalkyl is a monocyclic, bicyclic or tricyclic carbocyclic alkyl radical of 5-12 ring members, which is optionally partially unsaturated, benzo fused or heterocyclo fused; aryl is a phenyl or biphenyl radical which is optionally benzo fused or heterocyclo fused; heterocyclyl is a radical of a monocyclic or bicyclic saturated heterocyclic ring system having 5-8 ring members per ring, wherein 1-3 ring members are oxygen, sulfur or nitrogen heteroatoms, which is optionally partially unsaturated or benzo-fused and optionally substituted by 1-2 oxo or thioxo radicals; and heteroaryl is a monocyclic or bicyclic aromatic heterocyclic ring system having 5-6 ring members per ring, wherein 1-3 ring members are oxygen, sulfur or nitrogen heteroatoms, which is optionally benzo-fused or saturated C 3 -C 4 ~carbocyclic-fused. 3. The compound of Claim 2 or a pharmaceutically 4 3 acceptable salt thereof, wherein Y is -NR-C(0)-R 4. The compound of Claim 3 or a pharmaceutically acceptable salt thereof, wherein 2 X is 0 or NR ; 1 R is a cycloalkyl, aryl, heterocyclyl or heteroaryl radical which is optionally substituted by 1-4 radicals of C 1 -C 4 alkyl, halo, Cχ-C haloalkyl of 1-3 halo 18 18 18 radicals, cyano, azido, nitro, amidino, R -Z - or R - 18 Z -Cχ-C 4 alkyl; provided that the total number of aryl, heteroaryl, cycloalkyl and heterocyclyl radicals in R is 1-2; 18 . wherein each R is independently a hydrogen, Cχ-C 4 alkyl, trifluoromethyl, aryl, heteroaryl, aryl-Cχ-C 2 alkyl or heteroaryl-Cχ-C 2 alkyl radical; wherein the aryl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, C -C 4 alkoxy, Cχ-C 4 alkylthiol, amino, Cχ-C 4 alkylamino, di(Cχ-C 4 alkyl) amino, acetylamino, cyano, halo, azido, Cχ-C4 alkyl, trifluoromethyl or trifluoromethoxy; and 2 R is a hydrogen or Cχ-C 2 alkyl radical; R is an aryl or heteroaryl radical which is optionally substituted by 1-5 radicals of C -C 6 alkyl, halo, Cχ-C haloalkyl of 1-3 halo radicals, cyano, azido, nitro, amidino, R 1 -Z - or R -Z -Cχ-C 4 alkyl; provided that the total number of aryl and heteroaryl radicals in R is 1- 2 ; and 19 wherein each R is independently a hydrogen, Cχ-C 4 alkyl, trifluoromethyl, aryl, heteroaryl, aryl-Cχ-C 4 alkyl or heteroaryl-Cχ-C 4 alkyl radical; wherein the aryl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, Cχ-C 4 alkoxy, C -C 4 alkylthiol, amino, C -C 4 alkylamino, di (Cχ-C 4 alkyl) amino, acetylamino, cyano, halo, C -C 4 alkyl, trifluoromethyl or trifluoromethoxy; and 4 R is a radical of hydrogen, Cχ-C 6 alkyl, aryl, heteroaryl, aryl-Cχ-C 4 alkyl, heteroaryl-Cχ-C 4 alkyl or 20 20 R -Z -C 2 -C 4 alkyl radical; and 20 . wherein R is a hydrogen, Cχ-C 4 alkyl, aryl, heteroaryl, aryl-Cχ-C 2 alkyl or heteroaryl-Cχ-C 2 alkyl radical; 4 20 wherein the aryl and heteroaryl radicals of R and R are optionally substituted by 1-2 radicals of hydroxy, Cχ-C 4 alkoxy, C 1 -C 4 alkylthiol, amino, C -C 4 alkylamino, di(Cχ-C 4 alkyl) amino, acetylamino, halo, C -C 4 alkyl, trifluoromethyl or trifluoromethoxy; and 20 . 21 21 . , , ., Z is -0- or -NR -; wherein each R is independently a hydrogen or methyl radical; R and R are each independently a hydrogen, Cχ-C 4 alkyl, halo, trifluoromethyl, trifluoromethoxy, amino, Cχ-C4 alkylamino, di(Cχ-C 4 alkyl) amino, Cχ-Cs alkanoylamino, hydroxy, Cχ-C 4 hydroxyalkyl, C -C 4 alkoxy, cyano, azido, nitro, carboxy, (Cχ-C 4 alkoxy) carbonyl, aminocarbonyl, (Cχ-C 4 alkyl) aminocarbonyl or di(Cχ-C 4 alkyl) aminocarbonyl radical; and 7 R is a hydrogen, Cχ-C alkyl, halo, trifluoromethyl, trifluoromethoxy, hydroxy, Cχ-C 4 hydroxyalkyl, Cχ-C 4 alkoxy, carboxy, (Cχ-C 4 alkoxy) carbonyl, aminocarbonyl, (Cχ-C 4 alkyl ) aminocarbonyl or di(Cχ-C 4 alkyl ) aminocarbonyl radical; and wherein cycloalkyl is a monocyclic or bicyclic carbocyclic alkyl radical of 5-12 ring members, which is optionally partially unsaturated, benzo fused or heterocyclo fused; aryl is a phenyl or biphenyl radical which is optionally benzo fused or heterocyclo fused; heterocyclyl is a radical of a monocyclic or bicyclic saturated heterocyclic ring system having 5-8 ring members per ring, wherein 1-3 ring members are oxygen, sulfur or nitrogen heteroatoms, which is optionally partially unsaturated or benzo-fused and optionally substituted by 1-2 oxo or thioxo radicals; and heteroaryl is a monocyclic aromatic heterocyclic ring system having 5-6 ring members per ring, wherein 1-3 ring members are oxygen, sulfur or nitrogen heteroatoms, which is optionally benzo-fused or saturated C 3 -C 4 - carbocyclic-fused. 5. The compound of Claim 4 or a pharmaceutically acceptable salt thereof, wherein R is a radical of the formula wherein 13 U is C-R or N; 12 V and W are each independently C-R or N; 11 13 R and R are each independently a radical of hydrogen, Cχ-C 4 alkyl, halo, trifluoromethyl, cyano, azido, nitro, . , . 19 19 , 12 . amidino or R -Z -; and each R is independently a radical of hydrogen, Cχ-C δ alkyl, halo, Cχ-C 4 haloalkyl of 1-3 halo radicals, R -Z - or R -Z -Cχ-C 4 alkyl; provided that the combined total number of aryl and 11 12 13 heteroaryl radicals in R , R and R is 0-1; wherein each R 19 s independently a hydrogen, Cχ-C 4 alkyl, trifluoromethyl, aryl, heteroaryl, aryl-Cχ-C 4 alkyl or heteroaryl-Cχ-C 4 alkyl radical; wherein the aryl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, methoxy, ethoxy, amino, methylamino, dimethylamino, acetylamino, cyano, halo, methyl, ethyl, trifluoromethyl or trifluoromethoxy; and each Z is independently -0- , -S(0) 2 -, -C0 2 -, -C(O)-, - NR 21 -C(0)-, -C(0)-NR 21 -, -NR 21 -S(0) 2 - or -S (0) 2 -NR 21 - ; 31 wherein each R is independently a hydrogen, C -C 4 alkyl, trifluoromethyl, aryl, heteroaryl, aryl-Cχ-C 4 alkyl or heteroaryl-Cχ-C 4 alkyl radical; wherein the aryl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, methoxy, ethoxy, amino, methylamino, dimethylamino, acetylamino, cyano, halo, methyl, ethyl, trifluoromethyl or trifluoromethoxy; and each Z " is independently -0- , -NR -, -NR -C(O)-, -C(O)- NR 21 -, -NR 1 -S(0),- or -S(0),-NR 21 -; 4 wnerem R is a radical of hydrogen, Cχ-C δ alkyl, aryl, heteroaryl, aryl-Cχ-C 4 alkyl, heteroaryl-Cχ-C 4 alkyl or 20 20 R -Z -C 2 -C 4 alkyl radical; 20 wherein R is a hydrogen, Cχ-C 4 alkyl, aryl, heteroaryl, aryl-Cχ-C2 alkyl or heteroaryl-Cχ-C 2 alkyl radical; 20 wherein the aryl and heteroaryl radicals of R and R are optionally substituted by 1-2 radicals of hydroxy, methoxy, ethoxy, methylthiol, ethylthiol, amino, methylamino, dimethylamino, ethylamino, diethylamino, acetylamino, halo, methyl, ethyl, trifluoromethyl or trifluoromethoxy; and 5 6 R and R are each independently a hydrogen, methyl, ethyl, halo, trifluoromethyl, trifluoromethoxy, amino, C -C 2 alkylamino, di (Cχ-C 2 alkyl)amino, hydroxy, methoxy or ethoxy radical; and 7 R is a hydrogen, methyl, ethyl, halo, trifluoromethyl, trifluoromethoxy, hydroxy, methoxy or ethoxy radical; and wherein cycloalkyl is a monocyclic or bicyclic carbocyclic alkyl radical of 5-10 ring members, which is optionally partially unsaturated with one double bond, benzo fused or heterocyclo fused; aryl is a phenyl or biphenyl radical which is optionally benzo fused or heterocyclo fused; heterocyclyl is a radical of a monocyclic or bicyclic saturated heterocyclic ring system having 5-8 ring members per ring, wherein 1-3 ring members are oxygen, sulfur or nitrogen heteroatoms, which is optionally partially unsaturated or benzo-fused and optionally substituted by 1-2 oxo or thioxo radicals; and heteroaryl is a monocyclic aromatic heterocyclic ring system having 5-6 ring members per ring, wherein 1-3 ring members are oxygen, sulfur or nitrogen heteroatoms, which is optionally benzo-fused or saturated C 3 -C 4 ~carbocyclic-fused. 6. The compound of Claim 5 or a pharmaceutically acceptable salt thereof, wherein R is a radical of the formula wherein 22 23 24 25 „ 26 , ., _ R , R , R , R and R are each independently a radical of hydrogen, Cχ-C 4 alkyl, halo, trifluoromethyl, cyano, 18 18 18 18 azido, nitro, amidino, R -Z - or R -Z -C 1 -C 4 alkyl; 21 22 23 24 25 provided at least one of R , R , R , R and R is hydrogen; and provided that the combined total number of 22 23 24 25 26 aryl and heteroaryl radicals m R , R , R , R and R is 0-1; wherein each Z is independently -0-, -S-, -S(0) 2 -, CO-, -NR 21 -, -NR 21 -C(0)-, -C(0)-NR 21 -, -NR 21 -S(0) 2 - or S(0),-NR and wherein aryl is a phenyl or biphenyl radical which is optionally benzo fused or heterocyclo fused; and heteroaryl is a monocyclic aromatic heterocyclic ring system having 5-6 ring members per ring, wherein 1-3 ring members are oxygen, sulfur or nitrogen heteroatoms, which is optionally benzo-fused or saturated C 3 -C 4 ~ carbocyclie-fused. 7. The compound of Claim 6 or a pharmaceutically acceptable salt thereof, wherein X is NR 2 R is a hydrogen or methyl radical; 4 R is a radical of hydrogen, methyl or ethyl radical; and 5 6 7 R , R and R are each independently a hydrogen radical; and wherein aryl is a phenyl, biphenyl or naphthyl radical; and heteroaryl is a monocyclic aromatic heterocyclic ring system having 5-6 ring members per ring, wherein 1- 3 ring members are oxygen, sulfur or nitrogen heteroatoms . 8. The compound of Claim 7 or a pharmaceutically acceptable salt thereof, wherein 11 13 R and R are each independently a radical of hydrogen, methyl, ethyl, fluoro, chloro, trifluoromethyl, cyano, azido, nitro, amidino, R -0- , R -S(0) 2 -, R -O-C(O)-, R 19 -C(0)-, R 1 -NR 21 -C(0)- or R i9 -NR 21 -S (0) 2 - ; and each R 1 is independently a radical of hydrogen, methyl, ethyl, fluoro, chloro, trifluoromethyl, trifluoromethoxy, methoxy, ethoxy, amino, methylamino, dimethylamino, acetylamino, aminocarbonyl, methylaminocarbonyl, dimethylammocarbonyl , aminomethyl, (methylamino) methyl or (dimethylamino) methyl ; provided that the combined 11 12 total number of aryl and heteroaryl radicals in R , R and R is 0-1; and wherein each R 19 is independently a hydrogen, methyl, ethyl, trifluoromethyl, phenyl, heteroaryl, phenylmethyl or heteroaryl-methyl radical; wherein the phenyl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, methoxy, ethoxy, amino, methylamino, dimethylamino, acetylamino, cyano, fluoro, chloro, methyl, ethyl, trifluoromethyl or trifluoromethoxy. 9. The compound of Claim 2 or a pharmaceutically 3 4 acceptable salt thereof, wherein Y is -C(0)-NRR . 10. The compound of Claim 9 or a pharmaceutically acceptable salt thereof, wherein X is 0 or NR ; R is a cycloalkyl, aryl, heterocyclyl or heteroaryl radical which is optionally substituted by 1-4 radicals of C 1 -C 4 alkyl, halo, Cχ-C 4 haloalkyl of 1-3 halo 18 18 18 radicals, cyano, azido, nitro, amidino, R -Z - or R - Z -Cχ-C 4 alkyl; provided that the total number of aryl, heteroaryl, cycloalkyl and heterocyclyl radicals in R * is 1-2; 18 wherein each R is independently a hydrogen, Cχ-C 4 alkyl, trifluoromethyl, aryl, heteroaryl, aryl-Cχ-C 2 alkyl or heteroaryl-Cχ-C 2 alkyl radical; wherein the aryl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, C -C 4 alkoxy, Cχ-C 4 alkylthiol, amino, Cχ-C 4 alkylamino, di(Cχ-C 4 alkyl) amino, acetylamino, cyano, halo, azido, Cχ-C 4 alkyl, trifluoromethyl or trifluoromethoxy; and each Z " is independently -0- , -S-, -S(O)-, -S(0) 2 -, - C0 2 -, -C(0)-, -NR 21 -, -NR 2i -C(0)-, -C(0)-NR 21 -, -NR - 21 21 S(0) 2 - or -S(0) 2 -NR - ; wherein each R is independently a hydrogen or Cχ-C 4 alkyl radical; R is a hydrogen or C -C 2 alkyl radical; R is an aryl or heteroaryl radical which is optionally substituted by 1-5 radicals of Cχ-Cg alkyl, halo, C -C 4 haloalkyl of 1-3 halo radicals, cyano, azido, nitro, 19 19 19 19 amidino, R -Z - or R -z -Cχ-C 4 alkyl; provided that the 3 total number of aryl and heteroaryl radicals in R is 1- 2; and provided R is other than a phenyl or naphthyl having an amino, nitro, cyano, carboxy or alkoxycarbonyl substituent bonded to the ring carbon atom adjacent to 4 the ring carbon atom bonded to -NR - ; and 19 wherein each R is independently a hydrogen, Cχ-C4 alkyl, trifluoromethyl, aryl, heteroaryl, aryl-Cχ-C4 alkyl or heteroaryl-Cχ-C 4 alkyl radical; wherein the aryl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, Cχ-C 4 alkoxy, C -C 4 alkylthiol, amino, Cχ-C 4 alkylamino, di(Cχ-C 4 alkyl) amino, acetylamino, cyano, halo, Cχ-C 4 alkyl, j trifluoromethyl or trifluoromethoxy; and 4 R is a radical of hydrogen, Cχ-C δ alkyl, aryl, heteroaryl, aryl-Cχ-C 4 alkyl, heteroaryl-Cχ-C 4 alkyl or 20 20 R -Z -C 2 -C 4 alkyl radical; and 20 . wherein R is a hydrogen, Cχ-C 4 alkyl, aryl, heteroaryl, aryl-Cχ-C2 alkyl or heteroaryl-Cχ-C 2 alkyl radical; 4 20 wherein the aryl and heteroaryl radicals of R and R are optionally substituted by 1-2 radicals of hydroxy, C 1 -C 4 alkoxy, Cχ-C 4 alkylthiol, amino, C -C 4 alkylamino, di(Cχ-C 4 alkyl) amino, acetylamino, halo, C -C 4 alkyl, trifluoromethyl or trifluoromethoxy; and 20 . 21 , , 21 , , Z is -0- or -NR - ; wherein each R is independently a hydrogen or methyl radical; R and R are each independently a hydrogen, Cχ-C 4 alkyl, halo, trifluoromethyl, trifluoromethoxy, amino, Cχ-C 4 alkylamino, di(Cχ-C 4 alkyl) amino, Cχ-Cs alkanoylamino, hydroxy, Cχ-C 4 hydroxyalkyl, Cχ-C 4 alkoxy, cyano, azido, nitro, carboxy, (Cχ-C 4 alkoxy) carbonyl, aminocarbonyl, (Cχ-C 4 alkyl ) aminocarbonyl or di(Cχ-C 4 alkyl ) aminocarbonyl radical; and R is a hydrogen, Cχ-C 4 alkyl, halo, trifluoromethyl, trifluoromethoxy, hydroxy, Cχ-C 4 hydroxyalkyl, Cχ-C4 alkoxy, carboxy, (Cχ-C 4 alkoxy) carbonyl, aminocarbonyl, (Cχ-C 4 alkyl ) aminocarbonyl or di(Cχ-C 4 alkyl) aminocarbonyl radical; and wherein cycloalkyl is a monocyclic or bicyclic carbocyclic alkyl radical of 5-12 ring members, which is optionally partially unsaturated, benzo fused or heterocyclo fused; aryl is a phenyl or biphenyl radical which is optionally benzo fused or heterocyclo fused; heterocyclyl is a radical of a monocyclic or bicyclic saturated heterocyclic ring system having 5-8 ring members per ring, wherein 1-3 ring members are oxygen, sulfur or nitrogen heteroatoms, which is optionally partially unsaturated or benzo-fused and optionally substituted by 1-2 oxo or thioxo radicals; and heteroaryl is a monocyclic aromatic heterocyclic ring system having 5-6 ring members per ring, wherein 1-3 ring members are oxygen, sulfur or nitrogen heteroatoms, which is optionally benzo-fused or saturated C 3 -C 4 ~ carbocyclic-fused. 11. The compound of Claim 10 or a pharmaceutically acceptable salt thereof, wherein R is a radical of the formula wherein 12 V and W are each independently C-R or N; 11 13 R and R are each independently a radical of hydrogen, C -C 4 alkyl, halo, . trifluoromethyl , cyano, azido, nitro, 19 19 12 5 amidino or R -Z -; and each R s independently a radical of hydrogen, C -C 6 alkyl, halo, Cχ-C 4 haloalkyl y y -. ,. 31 31 3 1 31 of 1-3 halo radicals, R -Z - or R -Z -Cχ-C 4 alkyl; provided that the combined total number of aryl and 11 12 13 heteroaryl radicals in R , R and R is 0-1; provided y y, . 13 12 11 13 10 when U is C-R and V and W are each C-R , R and R are each other than a nitro, cyano, carboxy or alkoxycarbonyl radical; 19 wherein each R is independently a hydrogen, Cχ-C 4 15 alkyl, trifluoromethyl, aryl, heteroaryl, aryl-Cχ-C 4 alkyl or heteroaryl-Cχ-C 4 alkyl radical; wherein the aryl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, methoxy, ethoxy, amino, methylamino, dimethylamino, acetylamino, cyano, halo, 20 methyl, ethyl, trifluoromethyl or trifluoromethoxy; and each Z is independently -0-, -S(0) 2 -, -C0 2 -, -C(O)-, - NR 21 -C(0)-, -C(0)-NR 21 -, -NR 21 -S(0) 2 - or -S(0) 2 -NR -; 21 wherein each R is independently a hydrogen or methyl 25 radical; 31 wherein each R is independently a hydrogen, Cχ-C4 alkyl, trifluoromethyl, aryl, heteroaryl, aryl-Cχ-C4 alkyl or heteroaryl-Cχ-C 4 alkyl radical; wherein the 30 aryl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, methoxy, ethoxy, amino, methylamino, dimethylamino, acetylamino, cyano, halo, methyl, ethyl, trifluoromethyl or trifluoromethoxy; and 31 21 2 1 each Z is independently -0- , -NR -, -NR ' -C(O)-, -C(0) NR 21 -, -NR 21 -S(0) 2 - or -S (0) 2 -NR 21 - ; 4 R is a radical of hydrogen, Cχ-C δ alkyl, aryl, heteroaryl, aryl-Cχ-C 4 alkyl, heteroaryl-Cχ-C 4 alkyl or 20 20 R -Z -C 2 -C 4 alkyl radical; and 20 . wherein R is a hydrogen, Cχ-C 4 alkyl, aryl, heteroaryl, aryl-Cχ-C2 alkyl or heteroaryl-Cχ-C 2 alkyl radical; 4 20 wherein the aryl and heteroaryl radicals of R and R are optionally substituted by 1-2 radicals of hydroxy, methoxy, ethoxy, methylthiol, ethylthiol, amino, methylamino, dimethylamino, ethylamino, diethylamino, acetylamino, halo, methyl, ethyl, trifluoromethyl or trifluoromethoxy; and 5 6 R and R are each independently a hydrogen, methyl, ethyl, halo, trifluoromethyl, trifluoromethoxy, amino, C -C 2 alkylamino, di (Cχ-C 2 alkyl)amino, hydroxy, methoxy or ethoxy radical ; and R is a hydrogen, methyl, ethyl, halo, trifluoromethyl, trifluoromethoxy, hydroxy, methoxy or ethoxy radical; and wherein cycloalkyl is a monocyclic or bicyclic carbocyclic alkyl radical of 5-10 ring members, which is optionally partially unsaturated with one double bond, benzo fused or heterocyclo fused; aryl is a phenyl or biphenyl radical which is optionally benzo fused or heterocyclo fused; heterocyclyl is a radical of a monocyclic or bicyclic saturated heterocyclic ring system having 5-8 ring members per ring, wherein 1-3 ring members are oxygen, sulfur or nitrogen heteroatoms, which is optionally partially unsaturated or benzo-fused and optionally substituted by 1-2 oxo or thioxo radicals; and heteroaryl is a monocyclic aromatic heterocyclic ring system having 5-6 ring members per ring, wherein 1-3 ring members are oxygen, sulfur or nitrogen heteroatoms, which is optionally benzo-fused or saturated C 3 -C 4 -carbocyclic-fused. 12. The compound of Claim 11 or a pharmaceutically acceptable salt thereof, wherein R is a radical of the formula wherein 2 23 24 25 , 26 , . , , , -, R , R , R , R and R are each independently a radical of hydrogen, C -C 4 alkyl, halo, trifluoromethyl, cyano, 18 18 8 18 azido, nitro, amidino, R -Z - or R -Z -Cχ-C 4 alkyl; 21 22 23 24 25 . provided at least one of R , R , R , R and R is hydrogen; and provided that the combined total number of 2 2 23 24 25 26 aarryyll aannd heteroaryl radicals m R , R , R , R and R is 0-1; 21 each Z is independently -0-, -S-, -S(O) -CO. -NR 21 -NR 21 -C(0) -C(0)-NR -NR -S(O),- or ■S(0) 2 -NR 21 -; and wherein aryl is a phenyl or biphenyl radical which is optionally benzo fused or heterocyclo fused; and heteroaryl is a monocyclic aromatic heterocyclic ring system having 5-6 ring members per ring, wherein 1-3 ring members are oxygen, sulfur or nitrogen heteroatoms, which is optionally benzo-fused or saturated C -C 4 ~ carbocyclic-fused. 13. The compound of Claim 12 or a pharmaceutically acceptable salt thereof, wherein X is NR 2 R is a hydrogen or methyl radical; 4 R is a radical of hydrogen, methyl or ethyl radical; and 5 6 7 R , R and R are each independently a hydrogen radical; and wherein aryl is a phenyl, biphenyl or naphthyl radical; and heteroaryl is a monocyclic aromatic heterocyclic ring system having 5-6 ring members per ring, wherein 1- 3 ring members are oxygen, sulfur or nitrogen heteroatoms . 14. The compound of Claim 13 or a pharmaceutically acceptable salt thereof, wherein 11 13 R and R are each independently a radical of hydrogen, methyl, ethyl, fluoro, chloro, trifluoromethyl, cyano, 19 19 19 azido, nitro, amidmo, R -0-, R -S(0) 2 -, R -O-C(O)-, R 1 -C(O)-, R * -NR ' -C(O)- or R 19 -NR 2* -S(0) 2 -; provided when U is C-R " and V and W are each C-R , R and R are each other than a nitro, cyano, carboxy or alkoxycarbonyl radical; and provided that the combined total number of 11 13 aryl and heteroaryl radicals in R and R is 0-1; 12 . each R is independently a radical of hydrogen, methyl, ethyl, fluoro, chloro, trifluoromethyl, trifluoromethoxy, methoxy, ethoxy, amino, methylamino, dimethylamino, acetylamino, aminocarbonyl, methylammocarbonyl , dimethylammocarbonyl , aminomethyl , (methylamino) methyl or (dimethylamino) methyl ; and 19 wherein each R is independently a hydrogen, methyl, ethyl, trifluoromethyl, phenyl, heteroaryl, phenylmethyl or heteroaryl-methyl radical; wherein the phenyl and heteroaryl radicals are optionally substituted by 1-2 radicals of hydroxy, methoxy, ethoxy, amino, methylamino, dimethylamino, acetylamino, cyano, fluoro, chloro, methyl, ethyl, trifluoromethyl or trifluoromethoxy. 15. The compound of Claim 1 which is, 2-cyclohexyloxy-5- (2-chlorophenylcarbonylamino)pyridine, • 2-cyclohexyloxy-5- (2-methyIphenylcarbonylamino)pyridine j: 2-cyclohexyloxy-5- (2, 6-dichlorophenylcarbonylamino) pyridine; 2-cyclohexyloxy-5- (2 , 6-dimethyIphenylcarbonylamino) pyridine; 2- (2 , 4-dimethylphenoxy) -5- (2-chlorophenylcarbonylamino) pyridine; 2- (2, 4-dimethylphenoxy) -5- (2, 6-dichlorophenylcarbonyl amino) pyridine; 2 - ( 2 , 4 -dime thy lphenoxy) - 5 - ( 2 -methylphenylcarbonylamino ) pyridine ; 2- (2 , 6-dimethyl-4-chlorophenoxy) -5- (2 , 6-dimethylphenyl carbonylamino) pyridine; 2- (2-methyl-4-fluorophenoxy) -5- (2-methylphenylcarbonyl amino) pyridine; 2- (2-methyl-4-chlorophenoxy) -5- (2-chlorophenylcarbonyl amino)pyridine; 2- (2-methyl-4-chlorophenoxy) -5- (2-methylphenylcarbonyl amino) pyridine; 2- (2-methylphenoxy) -5- (2-chlorophenylcarbonylamino) pyridine; 2- (2-methylphenoxy) -5- (2 , 6-dichlorophenyl carbonylamino)pyridine; 2- (2-methylphenoxy) -5- (2-methylphenylcarbonyl amino)pyridine ; 2- (2-methyl-4-chlorophenoxy) -5- (2 , 6-dichlorophenyl carbonylamino) pyridine; 2- (2-methyl-4-chlorophenoxy) -5- (2, 6-dimethylphenyl carbonylamino)pyridine; 2- (4-chlorophenoxy) -5- (2 , 6-dimethylphenylcarbonylamino) pyridine; 2- (2-methyl-4-fluorophenoxy) -5- (2 , 6-dichlorophenyl carbonylamino)pyridine; 2- (2-methyl-4-fluorophenoxy) -5- (2 , 6-dimethylphenyl carbonylamino)pyridine; 2- (2-methylphenoxy) -5- (2 , 6-dimethylphenyl carbonylamino)pyridine; 2- (2-methyl-4-fluorophenoxy) -5- (2-fluorophenylcarbonyl amino)pyridine; 2- (2 , 4-dimethylphenoxy) -5- (2 , 6-dimethylphenylcarbonyl amino) pyridine; 2- (1-naphthyloxy) -5- (2-methylphenylcarbonylamino) pyridine; 2- (1-naphthyloxy) -5- (2, 6-dichlorophenylcarbonylamino) pyridine; 2- (1-naphthyloxy) -5- (2, 6-dimethylphenylcarbonylamino) pyridine; 2- (2-methyl-3-pyridyloxy) -5- (2 , 6-dichlorophenylcarbonyl amino ) pyridine ; 2- (2-methyl-4-chlorophenoxy) -5- ( (3 , 5-dimethyl-4- isoxazolyl) carbonylamino) pyridine ; 2- (2-methyl-4-chlorophenylthiol ) -5- (2- methylphenylcarbonyl amino) pyridine; 2- (2-methyl-4-chlorophenylthiol) -5- (2, 6- dimethylphenylcarbonyl amino ) pyridine; 2-cyclohexylamino-5- (2 , 6-dichlorophenylcarbonylamino) pyridine; 2-cyclohexylamino-5- (2, 6-dimethylphenylcarbonylamino) pyridine; 2- (2 -methylcyclohexylamino) -5- (2 , 6- dichlorophenylcarbonyl amino) pyridine; 2- (2-methylcyclohexylamino) -5- (2-methylphenylcarbonyl amino) pyridine ; 2- (2, 4-dimethyIphenylamino) -5- (2-fluorophenylcarbonyl amino) pyridine; 2- (2, 4-dimethyIphenylamino) -5- (2-chlorophenylcarbonyl amino) pyridine; 2- (2, 4-dimethylphenylamino) -5- (2, 6- dichlorophenylcarbonyl amino) pyridine; 2- (2-methyl-4-chlorophenylamino) -5- (2, 6- dichlorophenylcarbonylamino) pyridine; 2- (2 , 4-dimethylphenylamino) -5- (2-methylphenylcarbonyl amino) pyridine; 2- (2-methylphenylamino) -5- (2-methyIphenylcarbonyl amino ) pyridine; 2- (2-methylphenylamino) -5- (2, 6-dichlorophenylcarbonyl amino) pyridine; 2- (2-methyIphenylamino) -5- (2 , 6-dimethylphenylcarbonyl amino ) pyridine; 2- (2 , 4-dimethylphenylamino) -5- (2,6- dimethylphenylcarbonyl amino) pyridine ; 2- (2-methyl-4-chlorophenylamino) -5- (2-methylphenyl carbonylamino) pyridine; 2- (2-methyl-4-chlorophenylamino) -5- (2, 6-dimethylphenyl carbonylamino) pyridine; or 2- (2-methyl-4-chlorophenylamino) -5- (2-methylphenyl aminocarbonyl ) pyridine . 16. A pharmaceutical composition comprising a compound of Claim 1 and a pharmaceutically acceptable carrier. 17. A method for prophylaxis or treatment of inflammation comprising administering an effective amount of a compound of Claim 1. 18. A method for prophylaxis or treatment of inflammation comprising administering an effective amount of a composition of Claim 16. 19. A method of treating cancer which comprises administering an effective amount of a compound of Claim 1. 20. A method of treating cancer which comprises administering an effective amount of a composition of Claim 16. 21. A method for prophylaxis or treatment of rheumatoid arthritis, Pagets disease, osteophorosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS) , psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV) , influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount of a compound of Claim 1. 22. A method for prophylaxis or treatment of rheumatoid arthritis, Pagets disease, osteophorosis , multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, cancer, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount of a compound of Claim 16. 23. A method for prophylaxis or treatment of pain comprising administering an effective amount of a compound of Claim 1. 24. A method for prophylaxis or treatment of pain comprising administering an effective amount of a composition of Claim 16.

Inventors: JOSEY JOHN A, MANTLO NATHAN B, SCHLACHTER STEVEN T, JOSEY, JOHN, A., MANTLO, NATHAN, B., SCHLACHTER, STEVEN, T.
Applicants: AMGEN INC, AMGEN INC.
Application year: 1998
Main classification: C07D213
IPC codes: A61K31, A61P1, A61P3, A61P9, A61P11, A61P17, A61P19, A61P21, A61P25, A61P27, A61P29, A61P31, A61P35, A61P37, C07D213, C07D401, C07D405, C07D409, C07D413, C07D417, C07D471