INDIUM PHOTOSENSITIZERS FOR PDT

Abstract: The invention disclosed herein involves a phototherapeutic pyrrolic core complexed with a non-radioactive Indium atom. Complexation of Indium by the pyrrolic core forms a metalopyrrolic compound which influences enables these compounds to localize at target sites a phototherapy. Such functionally aids in both detection and phototherapy of disease sites, or provides functionality that binds to site specific receptors of a target area such that the therapy is improved.

Description: INDIUM PHOTOSENSITIZERS FOR PDT. BACKGROUND OF THE INVENTION Porphyrins and related pyrrolic macrocycles, particularly tetrapyrrolic macrocycles. as well as many other light absorbing compounds are currently receiving a great deal of attention with regard to photosensitized medicine, especially in the field of Photodynamic therapy (PDT) 1 . The therapy necessarily involves the localization of a photosensitizing agent at or near a site of disease. The sensitizer, upon illumination in the presence of oxygen, produces cytotoxic species of oxygen such as singlet oxygen or oxygen radicals, which destroy the diseased cells. As the sensitizer is innocuous at the therapeutic dose, and only becomes active on illumination with light of a specific wavelength, PDT offers the possibility of a level of control or selectivity in the treatment of diseases not found with other current methods (e.g. conventional chemotherapy). Photodynamic therapy has wide application to modern medicine, targeting diseases such as cancers, cardiovascular restenosis and plaques, psoriasis, viral infections, benign prostate hyperplasia and diabetic retinopathy. In addition, photodynamic therapy may also be useful for the sterilization of blood, an area of increasing concern, especially now with the advent of AIDS and the transmission of HIV through blood transfusions. Most research on PDT has centered on a complex mixture consisting of ill-defined porphyrin dimers, trimers and oligomers " , which is marketed under the designation Photofrin II®. This complex mixture has recently been recommended for approval in the treatment of obstructed endobronchial tumors by the Food and Drug Administration Advisory Panel. Although the mixture has demonstrated the potential benefits of PDT, it has by virtue of its composition a number of associated disadvantages. For example, each of its components has varied subcellular localizations, depending on structure and inherent differences in photophysical properties. This makes the inteφretation of pharmacokinetic data difficult. In addition, the composition of the oligomers is often difficult to reproduce and changes, depending on the conditions under which a solution thereof is stored. Hence, the true "active components" may vary considerably. The mixture has a less than optimal light absorption profile (630nm, ε-S fJOOcm/'M "1 ). Numerous studies on light penetration through tissues show that longer wavelength light penetrates deeper into tissues 4 . While not all applications of PDT require deep penetration of light, many applications of PDT require the maximum depth of light penetration possible (for example the treatment of brain tumors). The mixture has a severe adverse normal skin response to light, which often lasts for up to 12 weeks 5 after therapy. During this time patients must avoid strong light, as otherwise severe burns and edema occur. Several well characterized second generation sensitizers (SnET2 6 , ZnPc 7 , BPDMA 8 , THPC 9 ) are currently in phase I/II clinical trials and the continued development of new sensitizers that show improved therapeutic efficacy is crucial to the future progress of the therapy. The development of new photosensitizers that possess all the basic requirements to be effective PDT drugs is not an easy task. While the optimal photophysical properties of a second generation drug are well defined, the factors which aid in the localization of photosensitizers to tissues are not. Several investigators have attempted to ascertain structure-activity relationships in ring systems that lend themselves to chemical modification without dramatically influencing the photophysical properties of the compounds. Woodburn and coworkers, working on hematopoφhyrin based analogues, have proposed that anionic compounds tend to localize in lysosomes. while cationic photosensitizers tend to localize in the mitochondria. Pandey and coworkers have suggested that the lipophilicity of the compound is important, and have demonstrated in a chlorophyll derived series that PDT effects vary with the length of the ether carbon chain. Unfortunately, many of the correlation's found in one group of photosensitizing compounds do not transfer to different groups of photosensitizing compounds. Thus, while structure-activity relationships are valuable for a particular class of compound whose geometry and spatial arrangements vary only slightly, a different class of compound, that inherently has its own spatial and geometric parameters, must have its own structure- activity relationships investigated. This in itself is a large time consuming process with ultimately no guarantees of enhanced localization or improved PDT efficacy for the modified compound. The instant invention is based upon the discovery of a single simple chemical modification of compounds having a pyrrolic core involving the coordination of a non- radioactive indium salt into the central cavity of the pyrrolic core to produce an indium pyrrolic complex, which markedly enhances the biological efficacy of compounds as photosensitizers for PDT. Two isotopes of indium occur naturally: In" 3 and In" 5 ; the former (natural abundance 4.23%) has no radioactivity, while the latter (natural abundance 95.77%) has a half life of 6 x 10 14 years, and, as a result, is also considered to be non-radioactive. Other indium nuclides have half lives ranging from 50.0 days (for In" 4 " 1 ) to 0.2 second (for In 109m Λ 2)- THE PRIOR ART Tetrapyrroles containing Indium ' " (half life 2.81 days) and other metals are known in the art, being disclosed, by way of example, in Japanese Kokai 3-261786. 1991, Mauclaire et al., US patent No. 5, 268,371 and in Maier et al., US patent No. 5,674,467, which also disclose their use for diagnostic imaging. The metal-tetrapyrrole compounds are all water soluble, and contain functional groups capable of coupling a biologically active molecule, such as an antibody, to the tetrapyrrolic nucleus. The compounds usually are prepared by reacting a poφhyrin derivative with a solution of a salt of the metal to be complexed at a temperature and for a time sufficient to obtain the metal tetφyrrole compound. For example, when a metal salt of indium " ' is heated for three hours at 110°C. in a poφhyrin solution to which a mixture of acetic acid and sodium acetate has been added, an In" 'poφhyrin is produced. Although the preparation of such metallopoφhyrins is known and the compounds have been discussed in the context of radiocontrasting agents, suφrisingly, so far as is known, there has been no report on the efficacy of indiumpoφhyrins as therapeutic photosensitizers. In view of the substantial prior art involving indium tetrapyrroles, it is indeed suφrising to discover that complexes of non-radioactive indium with tetrapyrroles exhibit a marked improvement in their cytocidal effect in vivo when compared with other metallotetrapyrrole complexes. Sakata, US patent No. 4,849,207, discloses compounds having the following structure: where: Rl, R2, R4 and R6 are methyl, R8, RIO, Rl 1 and R12 are H, and R7 and R9 are CH 2 CH 2 COR13 (where R13 is a residue which results when H is removed from an amino acid), R3 and R5 are ethyl, and In is not radioactive, i.e., is In' ' 3 or In 1 ' 5 . Japanese Kokai 5-97857 discloses compounds having the following structure Where Rl is CH(OR)Me, R is alkyl, R2 is a residue derived by removing H from an amino acid, and M is 2H, Ga, Zn, Pd, In or Sn The following references are cited above: 1. For an overview of photodynamic therapy see "Photodynamic Therapy of Neoplastic Disease", Vol. I and II. Ed. Kessel, D., CRC Press, 1990. 2 ."Photodynamic Therapy of Neoplastic Disease", Vol. I and II. Ed. Kessel, D., CRC Press, 1990 pi- 12. 3. Byrne, C.J., Ward, A.D., Marshallsay, C.J. Photochem. Photobiol, 46, 575, 1987. 4. a)Svaasand, L.O.. Ellingsen. R. Photochem. Photobiol. 41, 73, 1985;b) Bolin, F.P., Preuss, L.E., Cain, B.W., in "Poφhyrin Localization and Treatment of Tumours". Eds. Doiron, D.R., Gomer., C.J. Alan Liss, New York, 211, 1984. 5. Razum, N., Balchum, O.J., Profio, A.E., Carstens, C. Photochem Photobiol. 46, 925, 1987. 6. Kessel, D., Morgan, A.R., Garbo, G.M., Photochem. Photobiol. , 54(2), 193, 1991. 7. Ginevra, F., Biffanti, S., Pagnan, A., Biolo, R., Reddi, E., Jori, G., Cancer Letters, 49, 59, 1990. 8. Aveline, B., Hasan, T., Redmond, R.W., Photochem. Photobiol. , 59(3), 328, 1994. 9. Bonnett, R., White, R.D., Winfield, U., Berenbaum, M.C., Biochem. J., 261, 277, 1989. SUMMARY OF THE INVENTION It is an object of the present invention to provide pyrrolic compounds that absorb light at long wavelengths for use in photodynamic therapy and diagnosis of disease states. It is another object to provide a reaction product of (A) P where P is a pyrrolic derivative and (B) In' 13 X and/or In 1 15 X 3 (where X is a charge balancing ion, either organic or inorganic) such as to provide the reaction product (C) PIn" n X n and/orPIn" 5 n X n , where indium is coordinated to the pyrrolic derivative and n =1, 2, 3. It is yet another object of the invention to provide a reaction product of (C) PIn" 3 n X n and/or PIn" 5 n X n with a neucleophile Y, such that a reaction product (D) PIn" 3 n Y n X z and/or PIn" 5 n Y n X z is obtained (where Y is a charge balancing ion, either organic or inorganic n= 1,2,3 and z = 0, 1, 2, 3). It is still another object to provide compounds PIn" 3 X and/or PIn" 5 X that may be used to treat diseases such as atherosclerosis, restenosis, cancer, cancer pre-cursors, non- cancerous hypeφroliferating diseases, psoriasis, macular degeneration, glaucoma and viruses, benign prostate hypeφlasia, rheumatoid arthritis and to aid in the diagnosis of these disease states. DESCRIPTION OF THE PERFERRED EMBODIMENTS The present invention provides derivatives of photoactivatable compounds, some of which are shown in the following Examples, in table 1, and in Figs. 1- 5 via the introduction of non-radioactive indium into the macrocycle. The resulting products can be used to diagnose and treat disease states. Additionally, the ligand on the indium complex may then be further chemically or biochemically modified ex-vivo or in-vivo to form a different pyrrolic indium complex which is capable of binding to important blood plasma components or cell transport proteins that enhance sensitizer uptake at the diseased tissue site. Additional functionality around the pyrrolic structure can be used to attach biomolecules, examples of which may be antibodies, growth hormones and growth factors or other disease specific molecules, or to aid such factors as water solubility, lipophilicity or hydrophobicity which are known factors that influence drug uptake in tumor disease tissue. The following Examples are presented solely for the puφose of disclosing and illustrating the invention, and are not to be construed as limiting. In all of the procedures described in the examples, indium, where used, was the natural material, a mixture of abouit 4.23% In" 3 and 95.77% In" 5 . The following abbreviations are used in the examples: mL means millilter or milliliters, g means gram or grams; mg means milligram or milligrams; μg means microgram or micrograms Example 1, Preparation of Indium Methyl pyropheophorbide from methyl pyropheophorbide : M is 2H in methyl pyropheophorbide, and a mixture of In' 13 Cl and In 1 15 Cl in Indium methyl pyropheophorbide Methyl pyropheophorbide (0.5g) was dissolved in acetic acid (lOOmL); Indium chloride (0.5 g) and anhydrous sodium acetate (0.5 g) were added, and the solution was refluxed for 3 hrs. The solution was taken to dryness by rotary evaporation and the solid residue dissolved in dichloromethane / water (lOOmL/ lOOmL). The organic layer was washed several times with 0.5 N HCl/water (200mL), collected and dried over anhydrous sodium sulfate (20g). The organic layer was filtered and evaporated to dryness. The resulting residue was crystallized from methanol / dichloromethane. Yield 0.45g. Example 2, preparation of Indium tert-butyl phthalocyanine: one of R2 and R3 is tert-butyl while the other and Rl and R4 are H; and M is In" 3 Cl, In" 5 Cl or a mixture of In Cl and In Cl 4-tert-butyl-l,2-dicyanobenzene (2g) and Indium chloride (2.0g) were mixed thoroughly in a round bottom flask with stirring. The mixture was heated at 160°C for 2 hrs and the reaction vessel cooled to room temperature. The crude phthalocyanine was extracted from the resulting green solid using hot dichloroethane and the green solution evaporated by rotary evaporation. The resulting solid was dissolved in 7% acetone / dichloromethane and chromatographed on silica using 7% acetone / dichloromethane as eluent. The major green fraction was collected and recrystallized from methanol/ dichloromethane. Yield , l.lg. Example 3, Preparation of Indium Benzoporphyrin derivative from Benzoporphyrin derivative dimethyl ester . Where M is In" 3 Cl, In" 5 Cl, or a mixture of In " Cl and In Cl in indium benzoporphyrin derivative dimethyl ester and 2H in Ring B isomer benzoporphyrin derivative dimethyl ester Ring B isomer, Benzopoφhyrin derivative dimethyl ester (lOOmg) was dissolved in acetic acid (50mL) and Indium chloride (0.2g) and anhydrous sodium acetate (0.2 g) were added; the solution was refluxed for 3 hrs. The solution was taken to dryness by rotary evaporation and the solid residue dissolved in dichloromethane / water ( lOOmL/ lOOmL). The organic layer was washed several times with 0.5 N HCl/water (200mL), collected and dried over anhydrous sodium sulfate (20g). The organic layer was filtered and evaporated to dryness. The resulting residue was chromatographed on silica using 5% MeOH / dichloromethane as eluent and the major green fraction collected. The solvent was removed by rotary evaporation and the solid crystallized from hexane / dichloromethane. Yield 50mg. Example 4, Preparation of Indium m-hydroxy tetraphenylchlorin:from Tetrakis (3- hydroxyphenyl)chlorin Where each R2 is OH, each Rl, R3, R4 and R5 is Hydrogen, In is a mixture of In" 3 Cl and In " 5 Cl, and Z is Cl Tetrakis (3-hydroxyphenyl)chlorin (lOOmg) was dissolved in acetic acid and the solution purged with argon. Indium chloride (0.2g) and anhydrous sodium acetate (0.2 g) was added and the solution refluxed for 3 hrs under argon. The solution was taken to dryness by rotary evaporation and the solid residue dissolved in dichloromethane / water (lOOmL/ lOOmL). The organic layer was washed several times with 0.5 N HCl/water (200mL), collected and dried over anhydrous sodium sulfate (20g). The organic layer was filtered and evaporated to dryness. The resulting residue was chromatographed on silica using 5% MeOH / dichloromethane as eluent and the major green fraction collected. The solvent was removed by rotary evaporation and the solid crystallized from hexane / dichloromethane. Yield 60mg. Example 5, preparation of In Octaethylbenzochlorin (9) from Octaethylbenzochlorin ("OEBC") Each of Rl through R8 is ethyl. In Octaethyl benzochloπn, M is 2H, and in Indium octaethyl benzochloπn M is In 1 ' Z, In Z or a mixture of In Z and In 1 15 Z; Z is Cl Octaethylbenzochlorin (lOOmg) was dissolved in acetic acid and Indium chloride (0.2g) and anhydrous sodium acetate (0.2g) were added. The solution was refluxed for 3 hrs under argon. The solution was taken to dryness by rotary evaporation and the solid residue dissolved in dichloromethane (lOmL). The resulting solution was chromatographed on silica using 5% MeOH / dichloromethane as eluent and the major green fraction collected. The solvent was removed by rotary evaporation and the solid crystallized from hexane / dichloromethane. Yield 1 lOmg. Example 6, preparation of InOEBCSO 2 NH(CH 2 ) 3 OH (10) from OEBCSO 2 NH(CH 2 ) 3 OH Each of Rl through R8 is ethyl In Octaethyl benzochlorin, M Is 2H, and in Indium Octaethyl benzochlorin M is a mixture of In" 3 Cl and In" 5 Cl R is S0 2 NH(CH 2 ) 3 OH OEBCSO 2 NH(CH 2 ) 3 OH (lOOmg) was dissolved in dimethylformamide (DMF) (25mL) and InCl 3 (lOOmg) was added. The solution was refluxed for 6 hrs and the DMF was removed by rotary evaporation. The residue was dissolved in dichloromethane (lOmL) and the resulting solution was chromatographed on silica using 5% MeOH / dichloromethane as eluent. A minor fore running green band was collected and discarded and the more polar major green fraction was collected. The solvent was removed by rotary evaporation and the solid crystallized from hexane / dichloromethane. Yield 52mg. Example 7, Preparation of (17) frnm O R Γ , C Π O] ' ^CH2CH OCH CH OCH CH OCH2CH-)OCH ^CHJCH 2 OCH 2 CH 2 OCH 2 CH 2 OCHJCH 2 OCH 3 Where each of Rl through R8 is ethyl M is In Z, In Z, or a mixture of In" 3 Z and In" 5 Z in In Octaethyl benzochlorin and 2H in Octaethyl benzochlorin ^CH 2 CH : OCH 2 CH-,OCH : CH 2 OCH 2 CH 2 OCH, R i s so 2^ CH:!CH:;OCH2CH2θCH:!CH2θCH2CH2θCHι Z is Cl OEBCSθ 9 N"^- H 2 H 2 OCH 2 CH OCH 2 CH 2 θCH 2 CH 2 θCH 3 QQ ■ , was ^CH 2 CH 2 θCH 2 CH 2 θCH 2 CH 2 θCH 2 CH 2 θCH 3 dissolved in acetic acid (150mL) and Indium chloride (0.4g) and anhydrous sodium acetate (0.3g) were added. The solution was refluxed for 3 hrs under argon. The solution was taken to dryness by rotary evaporation and the solid residue dissolved in dichloromethane (lOmL). The resulting solution was chromatographed on silica using 5% acetone / dichloromethane as eluent and the major green fraction collected. The solvent was removed by rotary evaporation and the solid crystallized from hexane / dichloromethane. Yield 420mg. Example 8, Preparation of InOEBCSO 2 NHC(CH 2 OH) 3 (19) from OEBC SO 2 NHC(CH 2 OH) 3 Each of Rl through R8 is ethyl In Octaethyl benzochlorin, M Is 2H, and in Indium Octaethyl benzochlorin M is a mixture of In 113 Cl And In" 5 Cl R is S0 2 NHC(CH 2 OH) 3 OEBCSO 2 NHC(CH 2 OH) 3 (lOOmg) was dissolved in bromobenzene (50mL) and Indium chloride (0.2g) and anhydrous sodium acetate (0.2g) were added. The solution was refluxed for 5 hrs under argon. The solution was taken to dryness by rotary evaporation and the solid residue dissolved in dichloromethane (lOmL). The resulting solution was chromatographed on silica using 5% acetone / dichloromethane as eluent and the major green fraction collected. The solvent was removed by rotary evaporation and the solid crystallized from hexane / dichloromethane. Yield 105mg. Example 9, preparation of InOEBCSO 2 NH (CH 2 ) 4 CH(NH 2 )CO 2 H (21) from OEBCSO 2 NH (CH 2 ) 4 CH(NH 2 )CO 2 H Each of Rl through R8 is ethyl In Octaethyl benzochlorin. M Is 2H, and in Indium Octaethyl Benzochlorin M is a mixture of In 113 Cl an Inl l5 Cl R is S0 2 NH (CH 2 ) 4 CH(NH 2 )C0 2 H OEBCSO 2 NH (CH 2 ) 4 CH(NH 2 )CO 2 H (lOOmg) was dissolved in acetic acid and Indium chloride (0.2g) and anhydrous sodium acetate (0.2g) were added. The solution refluxed for 3 hours under argon. The solution was taken to dryness by rotary evaporation and the solid residue dissolved in dichloromethane (lOmL). The resulting solution was chromatographed on silica using 5% MeOH / dichloromethane as eluent and the major green fraction collected. The solvent was removed by rotary evaporation and the solid crystallized from hexane / dichloromethane. Yield 1 lOmg. Example 10, Preparation of Indium 2-desvinyl-2-acetyl pyropheophorbide (26) from 2-desvinyl-2-acetyl pyropheophorbide (26) M is 2H in 2-desvinyl-2-acetyl Pyropheophorbide and a mixture of In" 3 Cl and In" 5 Cl in Indium-2-desvinyl-2-acetyl pyropheophorbide 2-Desvinyl-2-acetyl pyrropheophorbide (lOOmg) was dissolved in acetic acid and Indium chloride (0.2g) and anhydrous sodium acetate (0.2g) were added. The solution was refluxed for 3 hrs under argon. The solution was taken to dryness by rotary evaporation and the solid residue dissolved in dichloromethane (lOmL). The resulting solution was chromatographed on silica using 5% acetone / dichloromethane as eluent and the major green fraction collected. The solvent was removed by rotary evaporation and the solid crystallized from hexane / dichloromethane. Yield lOOmg. Example 11, Preparation of Indium 2-desvinyl-2-formyl pyropheophorbide (27) from 2-desvinyl-2-formyl pyropheophorbide M is 2H in 2-desvinyl-2-formyl Pyropheophorbide and a mixture of In" 3 Cl and In" 5 Cl in Indium-2-desvinyl-2-formyl pyropheophorbide 2-Desvinyl-2-formyl pyropheophorbide (lOOmg) was dissolved in acetic acid (20mL) and Indium chloride (lOOmg) was added. Diisopropylefhylamine (0.3ml) was added and the solution refluxed until no more starting material remained by TLC (5%acetone / dichloromethane). The acetic acid was removed by rotary evaporation and the residue dissolved in dichloromethane and washed with 10% NH 4 C1 (2 x 50mL). The organic phase was separated, dried over sodium sulfate filtered and rotoevaporated to dryness. The residue was dissolved in dichloromethane and purified by chromatography on silica using 5% acetone / dichloromethane as eluent followed by 20% acetone / dichloromethane as eluent. A less polar green fraction was collected and recrystallized from dichloromethane / hexane. A second more polar green fraction was collected and discarded. Yield of (27) = 62mg. Example 12, preparation of Indium Chlorin e6 trimethyl ester (28) from Chlorin e6 trimethvl ester M is 2H in Chlorin e6 Trimethyl eater and a mixture of In l l Cl and In" 5 Cl in Indium-Chlorin e6 trimethyl ester Chlorin e6 trimethyl ester (150mg) was dissolved in acetic acid (20mL) and Indium chloride (150mg) added. Diisopropylethylamine (0.3ml) was added and the solution refluxed until no more starting material remained by TLC (5%acetone / dichloromethane). The acetic acid was removed by rotary evaporation and the residue dissolved in dichloromethane and washed with 10% NH 4 C1 (2 x 50mL). The organic phase was separated, dried over sodium sulfate, filtered and rotoevaporated to dryness. The residue was dissolved in dichloromethane and purified by chromatography on silica using 5% acetone / dichloromethane as eluent followed by 20% acetone / dichloromethane as eluent. The major green fraction was collected and re-purified by chromatography on silica using 5% acetone / dichloromethane as eluent. The major green fraction was collected and recrystalized from dichloromethane / hexane. Yield, 67mg Various compounds comprised essentially of a non-radioactive indium atom complexed with the inner nitrogens of a pyrrolic core have been evaluated biologically as photosensitizers. The results of some of this evaluation are summarized below. In Vitro Biological Evaluation of Functionalized Benzochlorins. The in vitro biological evaluation of certain photosensitizers was determined, using standard procedures. Several of the photosensitizers had the following structure: where each of Rl through R8 was ethyl and R and M had various meanings The identities of a first group of the compounds tested, all of which had the foregoing structure, of an arbitrary "Sensitizer Number" assigned for reference puφoses, and the Example (if any) where their preparation is described are set forth below: Sensitizer Number 14 SO 2 N ^ N(CH ^ N(CH 3 ) 2 Sensitizer Number 15 SO 2 NHCH 2 CH 2 N: Sensitizer Number 19 NH 2 Sensitizer Number 21 SO 2 NH(CH 2 ) 4 CHCO 2 H The identities of a second group of compounds tested, all of which had the following structure, of an arbitrary "Sensitizer Number" assigned for reference puφoses, and the Example, (if any) where their preparation is described are set forth below: Sensitizer Example Identity of Identity of Rl Number (if any) M in forein foregoing going formula formula 22 2H Vinyl 23 SnCl 2 Vinyl 24 InCl Vinyl 25 InCl Ethyl 26 10 InCl COCH 3 27 11 InCl CHO 28 12 Pd COCH 3 A third group of the sensitizers had the folowing formula: Sensitizer Example Identity of Identity of Rl Identity of R2 Number (if any) M in forein foregoing in foregoing going formula formula formula 29 a mixture of Vinyl CH 2 CO 2 CH 3 In" 3 Cl and In 115 Cl 30 a mixture of Ethyl CH>CO,CH 3 In" 3 Cl and In" 5 Cl 31 a mixture of Vinyl CO 2 CH 3 In" 3 Cl and In 115 Cl 32 a mixture of Ethyl CO 2 CH 3 In" 3 Cl and In" 5 Cl For the Biological Evaluation, Chinese hamster lung fibroblasts (V-79) obtained from the American Tissue Culture Collection were grown in D-MEM supplemented with 10% fetal calf serum at 37°C, 5% CO2, and 95% humidity. These cells were used to evaluate the sensitizers for dark and light toxicity, and cellular uptake. Medium was replaced with 5% fetal calf serum supplemented medium during sensitizer incubations. In the first phase, the combination of intracellular and extracellular concentration of photosensitizer required for lethal damage to 50% of the cells in culture (DC(50)) on light exposure was determined by plating cells at a density of 100 cells / cm^ and incubating for 1-3 hours to allow attachment of the cells. Cells were incubated with various concentrations of sensitizer ([C]= 0.01-l.OμM) delivered in non-toxic concentrations of DMSO/ 5% dextrose solution or in some cases in egg yolk phosphatidase (EYP) for 16-24 hours. The cells were then irradiated with laser light using a tunable Lexel argon pumped dye laser at the band I absoφtion of the photosensitizer. Total power density was adjusted to 12.5 mW/cm^ and a total light dose of 1.25 J/cm^ was applied. After treatment, cells were washed with HBSS, refed with 10% FBS supplemented DMEM with phenol red and incubated for 3-5 days to allow colony formation. Cells were fixed in methanol, stained with Giemsa, and colonies were counted. Plating efficiency was determined using a control colony and the mean percent survival fraction plotted against the sensitizer concentration and the DC50 established (Table 5). Several photosensitizers were screened by a standard cellular uptake protocol. A lOμM stock solution of photosensitizer in EYP was prepared by dilution of the photosensitizer stock (lmM) using 5% dextrose solution. Monolayer V-79 cells in the log phase of growth in 12- well tissue culture plates were incubated with 0.2mL of the lOμM solution of photosensitizer for time periods of 0, 12, 36, 48hrs. Following incubation the cells were washed with PBS (lmL) three times, then washed with HBSS ( lmL) and detached using lOOμL of trypsin. Individual wells containing cells were lysed by three freeze thaws. Spiking experiments were performed to confirm that the sensitizer could be adequately recovered using standard procedures. The sensitizer was then extracted from the cell debris with DMSO, centrifuged and the supernatant examined for fluorescence. Sensitizer concentration was determined by comparison to a standard curve. Results are expressed in ug / ug protein. Untreated monolayers are used to determine cell count. Treated cells of each time point were used to determine the protein concentration using the BCA assay. The results for the photosensitizers studied are presented in Table 2. Results shown are the mean of the three experiments for each timepoint. As can be clearly seen for the compounds tested, indium compounds had clearly a much lower DC(50)(light) values, regardless of the functionality attached to the chlorin. In Vivo Assay of Photosensitizers on Tumors Female C3H/HeJ mice (8-9 weeks old) were subjected to trochar implantation of BA mammary carcinoma on the hind leg of the animals. Animals having tumors ca 5mm in diameter were entered into the in vivo screen. For each new photosensitizer, a group of at least three mice were used to ascertain a drug dose that caused a response as described in table 3 when treated with the appropriate wavelength of light. Generally in this series, animals were injected with 1 μ mole of sensitizer / Kg of body weight, formulated in egg yolk phosphatidate (EYP), via the tail vein. At a defined time period later the animals were irradiated with light from a laser source tuned to the wavelength of activation of the sensitizer. The power density of the laser was set at 75mW / cm " with a total light dose of 200J / cm 2 . The spot size was 1cm diameter. Results for each photosensitizer are shown in Table 3. Selected Kaplan-Meier curves for two different benzochlorin metal classes are shown below. The curves are identified by legend. Table 2. Photophysical measurements, DC(50)(light) and cellular uptake of Photosensitizers Table 3 10 15 20 25 30 35 40 Days Post PDT Kaplan-Meier survival Curves for SnOEBC 10 15 20 25 30 35 40 Days Post PDT Kaplan-Meier survival curves for InOEBC. The procedures of Examples 1-12 can be modified to produce other phototherapeutic compositions according to the invention, each such composition being comprised essentially of a non-radioactive indium atom complexed with the inner nitrogens of a pyrrolic core composed of at least two pyrroles. The modification involves merely substituting an equivalent amount of the free base of another compound having a pyrrolic core composed of at least two pyrroles for the methyl pyropheophorbide, the benzopoφhyrin derivative, the tetrakis (3-hydroxyphenyl)chlorin, the octaethylbenzochlorin of Examples 1, 3, 4, 5, and 6 or for the corresponding starting materials of Examples 7-12, or by substituting other dicyano compounds capable of forming functionalized phthalocyanines, functionalized naphthocyanines or the like for the 4-tert- butyl- 1 ,2-dicyano benzene of Example 2. Examples of compounds having a pyrrolic core composed of at least two pyrroles, and which can be substituted as described in the preceding paragraph to produce additional compounds according to the instant invention are named in Table 1, and defined by reference to Figures 1-58, which follow the Table. Table 1: Pyrrole-derived macrocyclic compounds (Fig.1). Naturally occurring or synthetic poφhyrins and derivatives thereof (Fig. 2) Naturally occurring or synthetic chlorins and derivatives thereof (Figs. 3, 16, 17, 32-35 and 48-55) Bacteriochlorins and isobacteriochlorins (Figs. 4, 5 and 36-47)) Phthalocyanines, Naphthalocyanines and derivatives thereof (Figs. 6, 7, 15, 18- 21. 24, 26. 29. 30, 31 and 56) Poφhycenes and derivatives thereof (Fig. 8) Poφhycyanines and derivatives thereof (Fig.9) Pentaphyrins, sapphyrins and derivatives thereof (Figs. 10 and 1 1) Texaphyrins and derivatives thereof (Fig. 12) Benzochlorins and derivatives thereof (Fig. 13) Chlorophylls and derivatives thereof (Fig.14) Corroles (Fig. 58) FIGURE 3 FIGURE 12 FIGURE 23 FIGURE 24 FIGURE 25 FIGURE 27 FIGURE 28 FIGURE 35 FIGURE 36 FIGURE 37 FIGURE 38 FIGURE 39 FIGURE 40 FIGURE 41 FIGURE 42 FIGURE 46 FIGURE 47 FIGURE 48 FIGURE 49 FIGURE 50 FIGURE 51 FIGURE 52 FIGURE 53 FIGURE 54 FIGURE 55 FIGURE 56 FIGURE 57 Examples and illustrations from the literature outlined in Table 1 and Figures 1 to 57 of types of photosensitizers that may be used in photodynamic therapy or imaging and are applicable to the insertion of indium into the central core are as follows: Dipyrromethenes: (Figure 1). Dipyrromethenes have been used widely as intermediates in the synthesis of porphyrins (for example "The Porphyrins" Ed. D. Dolphin, Academic Press, 1978, Volume II. 215-223; Volume I, Chapter IV, 101-234. References within these volumes provide actual experimental details. These compounds can be coordinated with metal salts to produce metallo complexes (for example A.W. Johnson, I.T. Kay, R. Price, K.B. Shaw, J. Chem. Soc, Perkin Trans I, 3416-3424, 1959; S.M. Bloom, P.P. Garcia; J.H. Boyer, L.R. Morgan US Patent 5,189,029; date of patent Feb 23, 1993; L.R. Morgan, J.H. Boyer, U.S Patent 5,446,157). As shown in Figure 1, these molecules can be synthesized such that a wide variety of functionality can be directly attached to the basic diyrromethene ring structure. Such functionality can be used to increase water solubility, lippophilicity, conjugation to biomolecules such as antibodies or proteins, to increase the wavelength of absorption of the molecules (by increasing the conjugation of the macrocycle). As such, these molecules can be used for light activated photochemistry or diagnosis. Porphyrins: (Figure 2) Routes to the synthesis of the ubiquitous tetrapyrrolic macrocycles that contain in their macrocyclic ring system 11 double bonds (excluding peripheral substituents), is outlined in detail in several books including "Porphyrins and Metalloporphyrins" Ed. K.M. Smith, Elsevier Publishing Company, New York, 1975, Chapter 2, p29-55: chapter 19, p778-785 and "The Porphyrins" Ed. D.Dolphin, Academic Press, 1978, Volume I. References within these volumes provide actual experimental details. A very large number of porphyrinic compounds have been synthesized. As they are prevalent in nature, a large number of studies on the chemical modification of these compounds have been undertaken ("The Porphyrins" Ed. D.Dolphin, Academic Press, 1978, Volume I, p 289-339.). A great deal of work has been undertaken on the synthesis of porphyrins from mono-pyrrols ("The Porphyrins" Ed. D.Dolphin, Academic Press, 1978, Volume I, chapter 3, 85-100; chapter 4, 101-234, chapter 5, 235-264; chapter 6, 265-288). Notable valuable examples of such work is in the synthesis of mono, di, tri and tetraphenyl porphyrins ("The Porphyrins" Ed. D.Dolphin, Academic Press, 1978, Volume I, chapter 3, 88-90; Gunter, M.J., Mander, L.N., J. Org. Chem. 46, 4792-4795, 1981.). Such compounds can be widely functionalized as the aromatic rings may possess different substituents or have incorporated in them heteroatoms. Porphyrins also can be synthesized that possess annelated aromatic rings on the β-pyrrole positions (T.D. Lash, C.Wijesinghe, A.T. Osuma, J.R. Patel, Tetrahedron Letters, 38(12), 2031-2034. 1997.) which can have the effect of extending conjugation and modifying the absoφtion and photophysical properties of the compounds. Porphyrin type compounds have been synthesized from pyrroles and 5 -membered ring heterocycles (such as thiophenes or furans for example) which incorporates one or more heteroatom besides nitrogen within the central poφhyrin "core" ("Poφhyrins and Metallopoφhyrins" Ed. K.M. Smith, Elsevier Publishing Company, New York, 1975, Chapter 18, 729-732). Such compounds can be modified similarly to produce highly functionalized derivatives. In addition poφhyrin dimers, trimers or oligomers have been synthesized with great abandon. ( H. Meier, Y. Kobuke, S. Kugimiya, J. Chem. Soc. Chem. Commun., 923, 1989; G.M. Dubowchik, A.D. Hamilton, J. Chem. Soc. Chem. Commun.,904, 1985; R.K. Pandey, F-Y. Shaiu, C.J. Medforth, TJ. Dougherty, K.M. Smith, Tetrahedron Letters, 31, 7399, 1990; D.R. arnold, L.J. Nitschinsk, Tetrahedron Letters, 48, 8781, 1992; J.L. Sessler, S. Piering, Tetrahedron Letters, 28, 6569, 1987; A. Osaku, F. Kobayashi, K. Maruyama, Bull. Chem. Soc. Jpn, 64, 1213, 1991 ). Chlorins: (Figures 3, 16, 17, 31-34, 47-54) Chlorins or Hydropoφhyrins are poφhyrins that have only 10 double bonds in their macrocyclic ring system (excluding peripheral substituents). The "reduction" of the poφhyrin macrocycle has pronounced effects on both the absoφtion profile of the macrocycle and the photophysical properties of the compound. Many naturally occuring chlorins may be extracted from plants, seaweeds or algae (e.g. "Poφhyrins and Metallopoφhyrins" Ed. K.M. Smith, Elsevier Publishing Company, New York, 1975, Section H, p774 -778.) and simple chemical modifications to pheophorbide can give pyrropheophorbides, chlorin e6, puφurin 18 and other chlorin ring systems. Routes to the synthesis of chlorin macrocycles are outlined in "Poφhyrins and Metallopoφhyrins" Ed. K.M. Smith, Elsevier Publishing Company, New York, 1975, Chapter 2, p61-l 16; Chapter 19, 774-778, "The Poφhyrins" Ed. D.Dolphin, Academic Press. 1978, Volume II, pl-37, pl31-143. References within these volumes provide actual experimental details. Considerable research has been directed toward the synthesis of chlorin derivatives from poφhyrins. Catalytic hydrogenation and hydroboration (H.H. Inhoffen, J.W. Buchler, R. Thomas, Tetrahedon Letters, 1145, 1969;.), diimide reductions (H.W. Whitlock Jr., R Hanauer, R., Oester, m.Y.. B.K. Bower, J. Am. Chem. Soc. 91, 7585, 1969), osmium tetroxide (R. Bonnett, A.N. Nizhnick, M.C. Berenbaum, J. Chem. Soc. Chem. Comm., 1822, 1989) and hydrogen peroxide (C,K, Chang, Biochemistry, 19, 1971, 1971.) , alkali metals and electrochemical reduction (N.S. Hush, J.R. Rowlands, J. Am. Chem. Soc, 89, 2976. 1967), aromatic radicals ( G.L. Closs, L.E. Closs, J. Am. Chem. Soc, 85, 818, 1963) have all been successful at producing chlorins from poφhyrins. The use of light as a reductive tool has also been extensively studied by several authors. The reaction of singlet oxygen on vinyl poφhyrin has been used extensively to produce chlorins (H.H. Inhoffen, H. Brockman, K.M. Bleisnerv, Ann. Chem. 730, 173, 1969; D. Brault, C. Vever-Bizet, Mougee, C, Bensasson, R., Photochem. Photobiol., 47 151, 1988). The reduction of free base and metallopoφhyrins with light and and reducing agents (such as amines or ascorbates) (Y. Harel, J. Manassen, J. Am. Chem. Soc, 100, 6228, 1977: J.H. Fuhrhop, T. Lumbantobing, Tetrahedron Letters, 2815, 1970; D.G. Whitten, J.C., Yau., F.A. Carol, J. Am. Chem. Soc, 93, 2291, 1971.) also produces chlorins. Cyclization of meso-acrylate containing poφhyrins has been used extensively to produce puφurin derivatives (Figure 16 and 17) (A.R. Morgan, N.C. Tertel., J.Org. Chem.. 51, 1347, 1986) while acid cyclization of meso-acrolein poφhyrins has been used extensively to produce benzochlorins (Figure 13.) ( M.G.H, Vincente, LN. Rezzano, K.M. Smith, Tetrahedron Letters, 31, 1365, 1990; M.J. Gunter, B.C. Robinson, Tetrahedron., 47, 7853, 1991). Diels alder addition of dienophiles with vinyl containing poφhyrins has been used extensively to produce chlorins ( Figures 49-54) (R. Grigg. A.W. Johnson, A. Sweeney, Chem. Commun., 697. 1968, H.J. Callot, A.W. Johnson, A. Sweeney, J. Chem. Soc. Perkin Trans. I, 1424, 1973; V.S. Pangka, A.R. Morgan, D.Dolphin J.Org. Chem. 51, 1094, 1986; P. Yon-Hin, T.P. Wijesekera, D.Dolphin, Tetrahedron Letters, 32, 2875, 1991 ; P. Yon- Hin, T.P. Wijesekera, D.Dolphin, New. J. Chem, 16, 527, 1992; A.R. Morgan, D.Skalkos, G.M. Garbo, R.W. Keck, S.H. Selman J. Med. Chem. 34, 1991). Acetamidopoφhyrins can be cyclized to produce chlorins via a intramolecular Vilsmeier reaction (G.L. Collier, A.H. Jackson, G.W., Kenner, J. Chem. Soc, C, 564, 1969). Recently, chlorin analogues of Puφurin 18 based on puφurin 18, have been produced that possess nitrogens on the cyclic "anhydride" ring system (Figure 35, A or B = NR) (A.N. Kosyrev, G. Zheng, E. Lazarou, T. J. Dougherty, K.M. Smith, R. Pandey, Tetrahedron Letters, 38, 3335, 1997). Bacteriochlorins and isobacteriochlorins: (Figures 4, 5, 35 to 46) Bacteriochlorin and isobacteriochlorins are tetrahydropoφhyrins. These derivatives have only nine double bonds in their macrocyclic ring system (excluding peripheral groups). The "double" reduction of the poφhyrin nucleus at the pyrrole positions has a pronounced effect on the absoφtion properties and photophysical properties. Typically bacteriochlorins absorb in the 720-850nm range while isobacteriochlorins absorb in the 500-650nm range ("The Poφhyrins" Ed. D.Dolphin. Academic Press, 1978, Volume III, Chapter 1; References within these volumes provide actual experimental details). Examples of the synthesis of bacteriochlorins and isobacteriochlorins may be found in the following references; H, H Inhoffen. P. Jager and R. Mahlhop and CD. Mengler, Justus Liebigs Ann. Chem. 704, 188, 1967; H, H Inhoffen, P. Jager and R. Mahlhop and CD. Mengler, Justus Liebigs Ann. Chem. 704, 188, 1967; H. Mittenzwei, Hoppe-Seyler,s Z. Physiol. Chem. 275, 93, 1942; H. Brockmann Jr., G . Knobloch, Arch. Mikrobiol, 85, 123, 1972; J.J. Katz, H.H., Strain, A.L., Harkness, M.H. Studier, W.A., Svec, T.R. Janson, B.T. Cope, J. Am. Chem Soc. 94, 7983, 1972; D. Dolphin C Bruckner, Patent No: 5,648,485, Date of Patent Jul. 15, 1997; D. Dolphin, P.Y. Hin, T. Wijesekera Patent No: 5,149,708, Date of Patent: Sept 22, 1992; H.W. Whitlock, R. Hanauer, M.Y. Oester, B.K. Bower, J. Am. Chem Soc. 91, 7485, 1969; H, H Inhoffen, H. Sheer, Tetrahedron Letters, 1115, 1972; H, H Inhoffen, J.W. Buchler, R. Thomas, Tetrahedron Letters, 5145, 1969; J.H. Fuhrhop, T. Lumbantobing. Tetrahedron Letters, 2815, 1970; A. Scherz, Y. Saloman, L. Fiedor European patent No: 0584,552 A2: A. Scherz, Y. Saloman, L. Fiedor U.S patent No: 5,650,292; (A.N. Kosyrev, G. Zheng, E. Lazarus, T. J. Dougherty, K.M. Smith, R.Pandey, Tetrahedron Letters, 38, 3335, 1997). In particular, osmium tetroxide has proved useful in the synthesis of β,β- dihydroxy-bacteriochlorins and isobacteriochlorins from chlorins (R.K. Pandey, T.J. Dougherty, K.M. Smith, F.Y. Shiau, U.S. Patent No: 5,591,847) and the acid rearrangement of these derivatives has produced numerous bacteriochlorin derivatives. The treatment of poφhyrins and chlorins with hydrogen peroxide has been used to produce bacteriochlorins and isobacteriochlorins (H.H. Inhoffen, W. Nolte, Justus Liebigs Ann. Chem. 725, 167, 1969). Diels alder addition of dienophiles with poφhyrins containing two β-vinyl substituents has been used extensively to produce bacteriochlorins and isobacteriochlorins (R. Grigg, A.W. Johnson, A. Sweeney, Chem. Commun., 697, 1968, H.J. Callot, A.W. Johnson, A. Sweeney, J. Chem. Soc. Perkin Trans. I, 1424, 1973. ; P. Yon-Hin, T.P. Wijesekera, D.Dolphin, Tetrahedron Letters, 32, 2875, 1991; A.R. Morgan, D.Skalkos, G.M. Garbo, R.W. Keck, S.H. Selman J. Med. Chem. 34, 1991). Phthalocyanines and Naphthalocyanines; (Figure 6, 18, 21-24, 28-30) Phthalocyanines and phthalocyanine analogues are perhaps some of the most widely studied photosensitizers in the field of photodynamic therapy and are also widely used as optical recording media. As such the number of structurally different phthalocyanine derivatives is enormous. Not only can the peripheral functionality be widely varied which changes the electronic spectra and photophysics of the compounds, but metallation of the macrocycle also results in photophysical changes. In addition carbons in the aromatic rings may be substituted with heteroatoms (such as nitrogen, sulphur phosphorus) that change markedly the photophysical properties of the compounds. Examples of references that disclose the formation of such compounds are; "Phthalocyanines Properties and Applications, Eds. C.C Leznoff, A.B.P. Lever, VCH Publishers Inc., 1989; "The Phthalocyanines", Eds, F.H. Moser, A.L. Thomas, CRC Press, Volumes I and II, 1983; "The Poφhyrins" Ed. D.Dolphin, Academic Press, 1978, Volume I, Chapter 9, p 374-380, References within these volumes provide actual experimental details; A.K. Sobbi, D.Wohrle, D. Schlettwein, J. Chem. Soc Perkin Trans. 2, 481-488, 1993; J.H. Weber, D.H. Busch, Inorg. Chem. 192, 713, 1988.; R.P. Linstead, F.T. Weiss, J. Chem. Soc, 2975, 1950; M.E. Kenney, N.L. Oleinick, Patent No: 5,166,197, date of patent Nov 24, 1992; M.E. Kenney, N.L. Oleinick, Patent No: 5,484,778, date of patent Jan 16. 1996; P. Gregory, S.J. Reynolds, R.L. White, Patent No: 5,484,915, date of patent: Jan 16, 1996. A great number of binuclear phthalocyanines / napthalocyanines have been synthesised which share a common benzene or naphthalene ring (J. Yang, M.R. Van De Mark, Tetrahedron Letters, 34, 5223, 1993; N. Kobayashi, HY. Higashi, T. Osa, Chemistry letters, 1813, 1994. Azoporphyrins: (Figures 18, 20, 21, 30, 55) Poφhyrins that possess at least one meso-nitrogen linking atom are called azopoφhyrins. The number of meso-nitrogen linking atoms may be extended from one to four. Phthalocyanines and Naphthalocyanine may be regarded as tetraazopoφhyrins with extended conjugation due to annelated benzene and napthalene rings. The synthesis of mono, di, tri and tetraazopoφhyrin analogues is discussed in "The Poφhyrins" Ed. D.Dolphin, Academic Press, 1978, Volume I, Chapter 9, p 365-388; "Phthalocyanines Properties and Applications, Eds. C.C. Leznoff, A.B.P. Lever. VCH Publishers Inc., 1989; "The Phthalocyanines", Eds, F.H. Moser, A.L. Thomas, CRC Press, Volumes I and II, 1983. References within these volumes provide actual experimental details. The synthesis of a series of tetrabenzotriazopoφhyrins and tetranapthotriazopoφhyrins has recently been published (Y-H, Tse, A. Goel, M. Hue, A.B.P. Lever, C.C. Leznoff , Can. J. Chem. 71, 742, 1993.) and clearly it can be envisaged that chemistry typical of phthalocyanine chemistry and poφhyrin chemistry may be applied to these compounds, such that hetero atoms may be introduced into the annelated benzene or napthalene rings. Unsymmetrical benzonaphthoporphyrazines (Figures 25-27, 57 ) Unsymmetrical tetraazopoφhyrins that have both a benzene and a naphthalene annelated unit in the macrocyclic ring system are loosely called benzonaphthopoφhyrazines. The synthesis of these derivatives is carried out using classical phthalocyanine syntheses however, using mixed aromatic dinitriles (U. Michelsen. H. Kliesch, G. Schnuφfeil, A.K. Sobbi, D. Wohrle, Photochem. Photobiol, 64, 694, 1996; S.V. Kudrevich, H. Ali, J.E. Van Lier: Canadian Patent No: 2,130,853 Filed 25 / 8/ 1994). References to the synthesis of these macrocycles can also be found in "Phthalocyanines Properties and Applications, Eds. C.C Leznoff, A.B.P. Lever, VCH Publishers Inc., 1989; "The Phthalocyanines", Eds, F.H. Moser, A.L. Thomas, CRC Press, Volumes I and II, 1983. Texaphyrins: (Figure 12) Texaphyrins are tripyrrol dimethene derived "expanded poφhyrin" macrocycles who's central core is larger than that of a poφhyrin. The reaction of diformyl tripyrranes with functionalized aromatic diamines in the presence of a metal, gives rise to functionalized metallated texaphyrins (J.L. Sessler, G.W. Hemmi, T.D. Mody, U.S. Patent No: 5,252,720; J.L. Sessler, G.W. Hemmi, T. Murai, U.S. Patent No: 4,935,498; D. Magda, J.L Sessler, B. Iverson, P.L. Jansen, M. Wright, T D. Mody, G.W. Hemmi, U.S. Patent No: 5,567,687). Pentaphyrins and Sapphyrins:. (Figures 10, 11). Sapphyrins and pentaphyrins are fully conjugated macrocycles that possess five pyrrole units. Structural analogues of the sapphyrins and pentaphyrins are outlined in "Poφhyrins and Metalloporhyrins", Ed. K.M. Smith, Elsevier, Chapter 18, p750-751; "The Poφhyrins Ed. D Dolphin, Academic Press, NY, Chapter 10, p351-356; Broadherst et al, J. Chem. Soc. Perkin Trans. I , 2111, 1972; J.L Sessler, V. Krai, U.S. Patent 5,543,514). Porphycenes: (Figure 8). Poφhycenes are isomeric analogues of poφhyrins that have eleven double bonds in their macrocyclic core that are derived formally by a mere reshuffling of the pyrrole and methine moieties. Routes to the synthesis of functionalized poφhycenes are outlined in the following references; E.Vogel, C Richert, T. Benninghaus, M. Muller, A.D. Cross. U.S. patent 5,409,900; E.Vogel, C Richert, T. Benninghaus, M. Muller, A.D. Cross. U.S. patent 5,262,401: E.Vogel, P. A. Koch, A. Rahbar, A.D. Cross. U.S. patent 5,244,671; E.Vogel, M. Muller, A.D., O. Halpern, Cross. U.S. patent 5,610,175; E.Vogel, M. Muller, A.D.. O. Halpern, A.D. Cross. U.S. patent 5,637,608; E.Vogel, C Richert, T. Benninghaus, M. Muller, A.D. Cross. U.S. patent 5,179,120; D. Martire, N. Jux, P. F. Armendia, R.M. Negri, J. Lex, S. E. Braslavsky, K. Schaffner, E. Vogel. J. Am. Chem. Soc. 114, 1992; N. Jux, P. Koch, H. Schmickler, J.Lex, E.Vogel. Angew. Chem. Int. Ed. Engl. 29, 1385. 1990. Corroles: (Figure 57) Corroles contain an aromatic 18 electron chromophore. The synthesis and structural modifications of these compounds (such as N-alkylation) are discussed in detail in "The Poφhyrins" Ed. D.Dolphin, Academic Press, 1978, Volume I, Chapter 9, p 357- 363 and in "Poφhyrins and Metallopoφhyrins" Ed. K.M. Smith, Elsevier Publishing Company, New York, 1975, Chapter 18, p730 -749. It will be appreciated that various changes and modifications can be made from the specific details of the invention as disclosed above, and as described in the foregoing examples and that, in its essential details, the invention is a composition which is comprised essentially of a non-radioactive indium atom complexed with the inner nitrogens of a pyrrolic core composed of at least two pyrroles, with the proviso that fully unsaturated poφhyrins having the structures: where Rl, R2, R4 and R6 are methyl, R8, RIO, Rl l and R12 are hydrogen, and R7 and R8 are CH 2 CH 2 COR13 (where R 13 is a moiety which results from the removal of H from an amino acid), and where Rl is CH(OH)Me, R is alkyl, and R" is a residue derived by removing H from an amino acid are excluded. Preferably, the invention is a composition which is comprised essentially of a non- radioactive indium atom complexed with the inner nitrogens of a tetrapyrrolic core, with the proviso that the fully unsaturated poφhyrins identified above are excluded. A non- radioactive indium atom complexed with the inner nitrogens of a photosensitive compound having a dihydro or tetrahydro tetrapyrrolic core is another preferred composition of the invention. Other preferred families of compounds according to the invention have the structures of Figs. 1 to 58, above. Specifically, one preferred family has the structure of Fig. 2, where each of Rl through R12 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, vinyl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR12R12, CN, OH, OR12, CHO, (CH 2 ) n OH, (CH 2 ) n SH, (CH 2 ) n O-alkoxy, (CH 2 ) n SR12, (CH 2 ) n OR12 (where n = 1, 2, 3, 4, and R 12 is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO2R12 (where R12 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHR12, (CH 2 ) n CON(R12) 2 , CO 2 R12 (where R12 is a functional group less than or equal to 100000 daltons), SR12 (where R12 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R12, SO 2 NHR12, SO 2 N(R12) 2 , SO 2 N(R12) 3 + X " (where R12 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion). Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or a functional group less than or equal to 100000 daltons, protein or biomolecule, with the exclusions noted above when the pyrrolic core is fully unsaturated. Still another preferred family has the following structure: where each of Rl through R14 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, C(X) 2 C(X) 3 (where X is a halogen), NR15R15, CN, OH, OR15, CHO, COCH 3 , (CH 2 ) n OH, (CH 2 ) n SH, (CH 2 ) n O-alkoxy, (CH 2 ) n SR15, (CH 2 ) n OR15 (where n = 1, 2, 3, 4, and R15 is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO 2 R15 (where R15 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHR15, (CH 2 ) n CON(R15) 2 , CO 2 R15, CONHR15, CON(R15) 2 , (where R15 is a functional groups less than or equal to 100000 daltons), SR15 (where R 15 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R15, SO 2 NHR15, SO 2 N(R15) 2 , SO 2 N(R15) 3 τ χ- ( where R15 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In 1 15 or a mixture of In 113 and In" 5 ; Z is a halide, acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or a functional group less than or equal to 100000 daltons, proteins or biomolecules. M in the foregoing formula can also be Pd, Sn, Pt, Al, Ru, Ga. Another preferred family has the following structure: Where each of Rl through R4 is selected from SO 3 H (or a salt thereof), SO NHR5, CO 2 H (or a salt thereof), CONHR5, OH, OR5 (wherein R5 is a alcohol or ether containing group), amide, N(CH 3 ) 2 , N(Et) 2 . M is In" 3 , In 115 or a mixture of In" 3 and In" 5 Z is a halide, acetate, OH. M in the foregoing formula can also be Pd, Sn, Pt, Al, Ru, Ga. Another preferred family has the following structure: Where each of A, B. C, D and E is C, N, N + R (where R is alkyl charged or uncharged) or combinations thereof; M is In" 3 , In" 5 or a mixture of In 113 and In 115 and Z is a halide, acetate, OH. M is the foregoing formula can also be Pd, Sn, Pt, Al, Zn, Ru, Ga. Still another preferred family has the structure: Where each of Rl through R16 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), NR17R17, CN, OH, OR17, CHO, COCH 3 , CH(OR17)CH 3 , (CH2) n OH, (CH2) n SH, (CH2) n O-alkoxy, (CH2) n SR17, (CH2) n OR17 (where n = 1, 2, 3, 4, and R17 is a functional groups less than or equal to 100000 daltons), (CH2)nCO2R17 (where R17 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl or substituted alkyinyl, and n=l, 2, 3, 4), (CH2) n CONHR17, (CH2) n CON(R17)2„ CO 2 R17, CONHR17, CONR17R17, SR17 (where R17 is a functional groups less than or equal to 100000 daltons), SO 3 H. SO 3 R17, SO 2 NHR17. SO 2 N(R17) 2 . SO 2 N(R17) 3 +χ- (where R17 is a functional groups less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkyne, or functional groups less than or equal to 100000 daltons, proteins or biomolecules. Yet another family has the structure: Where each of Rl through R4 is SO 3 H (or a salt thereof), SO 2 NHR5, CO 2 H (or a salt thereof), CONHR5, OH, OR5 (wherein R5 is a alcohol or ether containing group), amide, N(CH 3 ) 2 , N(Et) 2 . M is In 1 13 , In 1 15 or a mixture of In 1 13 and In 1 15 Z is a halide, acetate, OH. M can also be Pd, Sn, Pt, Al, Zn, Ru, Ga. Still another family has the structure: Where each of A-E is C, N, or N + R (where R is a charged or uncharged alkyl group); M is In" 3 , In 115 or a mixture of In" 3 and In" 5 Z is halide, acetate, or OH. M can also be Pd, Sn, Pt, Al, Zn, Ru, Ga. Another family has the structure: Where each of Rl through R10 is H, halide, alkyl, cyclic alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), NR1 1R11, CN, OH, OR11, CHO, COCH 3 , CH(ORl l)CH 3 , (CH 2 ) n OH, (CH 2 ) n SH, (CH 2 ) n O-alkoxy, (CH 2 ) n SRl l, (CH 2 ) n ORl l (where n = 1, 2, 3, 4, and Rl l is a functional groups less than or equal to 100000 daltons), (CH 2 ) n CO 2 Rl l (where Rl l is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHRl l, (CH 2 ) n CON(Rl l) 2 , CO,Rl l, CONHR11, CONR11R1 1, SR1 1 (where Rl l is a functional groups less than or equal to 100000 daltons), SO 3 H, SO 3 Rl l, SO 2 NHRl l, SO 2 N(Rl l) 2 , SO 3 N(Rl l) 3 +X " (where Rl l is a functional groups less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide, acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or a functional group less than or equal to 100000 daltons, proteins or biomolecules. M can also be Pd, Sn, Pt, Al, Zn, Ru, Ga. Another family of compounds has the structure immediately above, where each of Rl, R2, R6, R7 is CO H (or a salt thereof), or CO 2 Rl 1 (where Rl 1 is alkyl or aryl). Each of R3 and R8 is methyl or ethyl. Each of R4, R5, R9, R10 is methyl, ethyl alkyl, CH 2 CH 2 CO 2 H (or salts therof), or CH 2 CH 2 CO 2 Rl 1 (where Rl 1 is alkyl or aryl). M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 and Z is a halide , acetate, OH. M can also be Pd, Sn, Pt, Al, Zn, Ru, Ga. Still another family of compounds has the structure: Where each of R1-R10 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, CH=CHCH 2 N(CH ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), NR11R11, CN, OH, OR11, CHO, COCH 3 , CH(ORl l)CH 3 , (CH 2 ) n OH, (CH 2 ) n SH, (CH 2 ) n O-alkoxy, (CH 2 ) n SRl l, (CH 2 ) n ORl l (where n = 1, 2, 3, 4, and Rl l is a functional group less than or equal to 100000 daltons), (CH,) n CO,Rl l (where Rl l is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHRl l. (CH 2 ) n CON(Rl 1) 2 , CO 2 Rl l, CONHR11, CONR11R11, SR11 (where Rl l is a functional groups less than or equal to 100000 daltons), SO 3 H, SO 3 Rl l, SO 2 NHRl l, SO 2 N(Rl l) 2 , SO 3 N(Rl l) 3 + X " (where Rl l is a functional groups less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In 115 or a mixture of In 1 13 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl; substituted alkynyl, or a functional group less than or equal to 100000 daltons, proteins or biomolecules. Another family of compounds has the structure: Where each of R1-R10 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyil, amide, ester, CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), NR11R11, CN, OH, OR11, CHO, COCH 3 , CH(ORl l)CH 3 , (CH 2 ) n OH, (CH 2 ) n SH, (CH 2 ) n O-alkoxy, (CH 2 ) n SRl l, (CH 2 ) n ORl l (where n = 1, 2, 3, 4, and Rl l is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO 2 Rl l (where Rl l is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHRl l, (CH 2 ) n CON(Rl l) 2 , CO2RH, CONHR11, CONR11R11, SR11 (where Rl l is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 Rl l, SO 2 NHRl l, SO 2 N(Rl l) 2 , SO 3 N(Rl 1) 3 + X " (where Rl l is a functional groups less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or a functional group less than or equal to 100000 daltons, protein or biomolecule. M can also be Pd, Sn, Pt, Al, Zn, Ru, Ga. Another family has the structure: where each of Rl, R2, R6, R7 is CO 2 H (or a salt thereof), CO 2 Rl 1 (where Rl 1 is alkyl or aryl). each of R3 and R8 is methyl or ethyl. each of R4, R5, R9, R10 is methyl, ethyl, alkyl, CH 2 CH 2 CO 2 H (or a salt therof), or CH 2 CH 2 CO 2 Rl 1 (where Rl 1 is alkyl or aryl). M is In" 3 , In" 5 or a mixture of In 1 13 and In 1 15 ; and Z is a halide . acetate, OH. M can also be Pd, Sn, Pt, Al, Zn, Ru, Ga. Yet another family of compounds has the following structure; Where each of R1-R14 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), NR15R15, CN, OH, OR15, CHO, COCH 3 , CH(OR15)CH 3 , (CH,) n OH, (CH,) n SH, (CH 2 ) n O-alkoxy, (CH,) n SR15, (CH2) n OR15 (where n = 1, 2, 3, 4, and R 15 is a functional groups less than or equal to 100000 daltons), (CH 2 ) n CO,R15 (where R15 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl. alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHR15, (CH,) n CON(R15) 2 , CO 2 R15, CONHR15, CONR15R15, SR15 (where R15 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R15, SO 2 NHR15, SO,N(R15) 2 , SO 3 N(R15) 3 + X " (where R15 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or a functional group less than or equal to 100000 daltons, protein or biomolecule. Still another family of compounds has the structure: Where each of Rl, R2, R3, R4, R8, R9, R10, Rl 1 is CN Each of R5 and R12 is methyl or ethyl. Each of R6, R7, R13 and R14 is methyl, ethyl, alkyl, CH 2 CH 2 CO 2 H (or salts thereof), or CH 2 CH 2 CO 2 R15 (where R15 is alkyl, aryl). M is In 1 13 , In 1 15 or a mixture of In 1 13 and In 1 15 . Z is a halide , acetate, or OH. M can also be Pd, Sn, Pt, Al, Zn, Ru, Ga. Another family of compounds has the structure: Where each of R1-R8 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), NR9R9, CN, OH, OR9, CHO, COCH 3 , CH(OR9)CH 3 , (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH 2 ) n SR9, (CH 2 ) n OR9 (where n = 1, 2, 3, 4, and R9 is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO 2 R9 (where R9 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHR9, (CH 2 ) n CON(R9) 2 , CO 2 R9, CONHR9, CONR9R9, SR9 (where R9 is a functional groups less than or equal to 100000 daltons), SO 3 H, SO 3 R9, SO,NHR9, SO,N(R9) 2 , SO 3 N(R9) 3 + X " (where R9 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion): M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or a functional group less than or equal to 100000 daltons, protein or biomolecule. Another family of compounds has the structure: where each of Rl and R5 is alkyl or aryl. Each of R2 and R6 is methyl or ethyl. Each of R7, R8, R3, and R4 is methyl, ethyl alkyl, CH 2 CH 2 CO H (or a salt therof), or CH 2 CH 2 CO 2 R9 (where R9 is alkyl or aryl). M is In 113 , In" 5 or a mixture of In" 3 and In" 5 . Z is a halide . acetate, OH. M can also be Pd, Sn, Pt, Al, Zn, Ru, Ga. Yet another family of compounds has the structure: Where each of R1-R14 is H, halide, methyl, ethyl, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, C(X) 2 C(X) 3 (where X is a halogen), NR15R15, CN, OH, OR15, CHO, COCH 3 , CH(OR15)CH 3 , (CH 2 ) n OH, (CH 2 ) n SH, (CH 2 ) n O-alkoxy, (CH 2 ) n SR15, (CH 2 ) n OR15 (where n = 1, 2, 3, 4, and R15 is a functional groups less than or equal to 100000 daltons), (CH,) n CO,R15 (where R14 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl. alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl and n=l, 2, 3, 4), (CH,) n CONHR15, (CH,) n CON(R15) 2 , CO,R15, CONHR15, CONR15R15, SR15 (where R15 is a functional group less than or equal to 100000 daltons and n=l, 2, 3, 4), SO 3 H, SO 3 R15, SO 2 NHR15, SO,N(R15) 2 , SO 3 N(R15) 3 + X " (where R15 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In 1 15 or a mixture of In" 3 and In 1 15 Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl. substituted alkenyl, alkynyl, substituted alkynyl, or a functional group less than or equal to 100000 daltons, protein or biomolecule. M can also be Pd. Sn, Pt, Al, Zn, Ru, Ga. Another family of compounds has the structure: where each of R1-R8 is ethyl or methyl R9 is CH 3 , SO,NH(CH,CH,O) n CH (n=l to 1000), SO,N((CH 2 CH,O) n CH 3 ), (n=l to 1000); SO,NH(CH,) n OH (n=l to 1000), CH 3 , SO,N((CH,CH,) n OH), (n=l to 1000); SO,NC((N(CH 3 ),), ; SO,NH(CH,) n N(CH 3 ), (n=l to 1000); SO 2 NH(CH,) n SH (n=l to 1000); SO,NHC(CH,CH,OH) 3 ; SO,NHCH 2 CO,H (or salts thereof); SO 2 NH(CH,) n CH(NH,)CO,H (or salts thereof) (n=l to 5); SO,NHCH 2 CO 2 R10 (R10 is alkyl, aryl); SO,NH(CH,) n CH(NH,)CO,R10 (R10 is alkyl, aryl) (n=l to 5) M is In 1 '\ In" 5 or a mixture of In 1 13 and In 1 15 Z is a halide , acetate, OH. M can also be Pd, Sn, Pt, Al, Zn, Ru, Ga. Another family of compounds has the structure: where each of R1-R8 is ethyl or methyl. R9 is; CH2CO,NH(CH,CH,O), 1 CH 3 (n=l to 1000), CH,CO,N((CH,CH 2 O) n CH 3 ), (n=l to 1000): CH : CO ; NH(CH,) π OH (n=l to 1000), CH,CO,N((CH,CH,) n OH), (n=l to 1000); CH 2 CO,NC((N(CH 3 ),) 2 ; CH,CO,NH(CH,) n N(CH 3 ), (n=l to 1000); CH,CO,NH(CH,) n SH (n=l to 1000); CH,CO,NHC(CH,CH,OH) 3 ; CH 2 CO,NHCH,CO,H (or salts thereof); CH,CO,NH(CH,) n CH(NH 2 )CO,H (or salts thereof) (n=l to 5); CH,CO,NHCH,CO 2 R10 (R10 is alkyl or aryl); CH 2 CO,NH(CH 2 ) n CH(NH,)CO,R10 (R10 is alkyl, aryl) (n=l to 5) M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 . Z is a halide , acetate, OH. M can also be Pd, Sn, Pt, Al, Zn, Ru, Ga. Another family has the structure: where each of R1-R8 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, C(X) 2 C(X) 3 (where X is a halogen), NR9R9, CN, OH, OR9, CHO, COCH 3 , (CH 2 ) n OH, (CH,) n SH, CH(OR9)CH 3 , (CH,) n O-alkoxy, (CH,) n SR9, (CH,) n OR9 (where n = 1, 2, 3, 4, and R9 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R9 (where R9 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR9, (CH,) n CON(R9) 2; CO 2 R9, CONHR9, CONR9R9, SR9 (where R9 is a functional groups less than or equal to 100000 daltons), SO 3 H, SO 3 R9, SO 2 NHR9, SO 2 N(R9) 2 , SO N(R9) 3 + X " (where R9 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl. alkynyl, substituted alkyinyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Pd, Sn, Pt, Al, Zn, Ru, Ga. Another family of compounds has the structure: where each of R1-R17 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester. C(X) 2 C(X) 3 (where X is a halogen), NR18R18, CN, OH, OR18, CHO, COCH 3 , (CH,) n OH, (CH,) n SH, CH(OR18)CH 3 , (CH,) n O-alkoxy, (CH,) n SR18, (CH,) n OR18(where n = 1, 2, 3, 4, and R5 is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO,R18 (where R18 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHR18, (CH,) n CON(R18) 2 , CO 2 R18, CONHR18, CONR18R18, SR18 (where R18 is a functional groups less than or equal to 100000 daltons), SO X, SO 3 R18, SO 2 NHR18, SO 2 N(R18) 2 , SO 2 N(R18) 3 + X " (where R18 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide, acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyil, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Pd, or Ga. Still another family has the structure: where each of R1-R24 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl. substituted alkenyl, alkynyl. substituted alkynyl. amide, ester. C(X) 2 C(X) 3 (where X is a halogen), NR25R25, CN, OH, OR25, CHO, COCH 3 , (CH2) n OH, (CH2) n SH, CH(OR25)CH 3 , (CH,) n O-alkoxy, (CH,) n SR25, (CH 2 ) n OR25 (where n = 1, 2, 3, 4, and R25 is a functional groups less than or equal to 100000 daltons), (CH 2 ) n CO,R25 (where R25 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR25, (CH,) n CON(R25) 2 , CO 2 R25, CONHR25, CONR25R25, SR25 (where R25 is a functional group less than or equal to 100000 daltons), SO H. SO 3 R25. SO 2 NHR25. SO 2 N(R25) 2 , SO 2 N(R25) ? "X " (where R25 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In 1 15 or a mixture of In" 3 and In" 5 ; A, B, C. D, E, F are; C, N, O+, O, S, Te, P, N + (R25)X ~ (where R25 is a functional groups less than or equal to 100000 daltons and X is a charge balancing ion), or combinations thereof; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl. alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Pd or Ga. Another family of compounds has the structure: where each of Rl- R5 is CH 2 CH . CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 CH=CHCH,N + (CH 3 ), X " (where X is a charge balancing ion). C(X) 2 C(X) (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R6, CONHR7, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR6 or is a functional group less than or equal to 100000 daltons), CH=CHCH 2 OH, CH=CHCH 2 OR6, CH(OH)CH 3 , CH(OR6)CH 3 , H, halide, alkyl, cyclic alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR6R6, CN, OH, OR6, (CH,) n OH, (CH 2 ) n SH, (CH,) n O-alkoxy, (CH 2 ) n SR6, (CH 2 ) n OR6 (where n = 1, 2, 3, 4, and R6 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R6 (where R6 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR6, (CH,) n CON(R6) 2 , CO 2 R6, CONHR6, CONR6R6, SR6 (where R6 is a functional group less than or equal to 100000 daltons), SO 3 H. SO R6, SO 2 NHR6, SO 2 N(R6) 2 , SO 2 N(R6) 3 "X " (where R6 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); X is , O, 2H, (H, OH), S. (H, OR6) or a ketone protecting group; M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkyinyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Pd, Sn, Pt, Al, Zn, Ru, Ga. Still another family of compounds has the structure: wherein: Rl is CH=CH 2 , CHO, Et, COCH 3 R2 is CO 2 CH 3 ,CO 2 H, amide R3 and R4 are H R5 is CH 3 X is O M is In" 3 , In" 5 or a mixture of In" 3 and In 115 Z is a halide, acetate or OH. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Nd, Pb, Pd, Pr, Pt, Rh, Sb, Sc, Sm, Sn, Pt, Ru, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb, Zn or Zr, preferably Pd, Sn, Pt, Al, Zn, Ru, Ga. Another family of compounds has the structure: where each of Rl- R6 is; CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R7, CONHR7, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR7 or is a functional group less than or equal to 100000 daltons), CH=CHCH 2 OH, CH=CHCH 2 OR7, CH(OH)CH 3 , CH(OR7)CH 3 , H, halide, alkyl, cyclic alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR7R7, CN, OH, OR7, (CH,)„OH, (CH 2 ) n SH, (CH 2 ) n O-alkoxy, (CH 2 ) n SR7, (CH,) n OR7 (where n = 1, 2, 3, 4, and R7 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R7 (where R7 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR7, (CH 2 ) n CON(R7) 2 , CO 2 R7, CONHR7, CONR7R7, SR7 (where R7 is a functional group less than or equal to 100000 daltons), SO H, SO R7, SO 2 NHR7, SO 2 N(R7) 2 , SO 2 N(R7) 3 + X _ (where R7 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide . acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl. alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons; with the proviso that when R2 = CO,NHR6, R6 can not be a mono- or di-carboxylic acid of an amino acid. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Nd, Pb, Pd, Pr, Pt, Rh, Sb, Sc, Sm, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb, Zr, preferably .Pd, Pt. Ga, Al, Ru, Sn or Zn. Another family of compounds has the following structure: where each of Rl- R6 is; CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO. COCH 3 , CO 2 H, CO 2 R7, CONHR7, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR7 or is a functional group less than or equal to 100000 daltons), CH=CHCH 2 OH, CH=CHCH 2 OR7, CH(OH)CH 3 , CH(OR7)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR7R7, CN, OH, OR7, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH 2 ) n SR7, (CH,) n OR7 (where n = 1. 2, 3, 4, and R7 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R7 (where R7 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHR7, (CH,) n CON(R7) 2 , CO 2 R7, CONHR7, CONR7R7, SR7 (where R7 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R7, SO 2 NHR7, SO 2 N(R7) 2 , SO N(R7) 3 + X " (where R7 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. Still another family of compounds has the following structure: wherein; Rl is CH=CH 2 , CHO, Et, COCH 3 R2 is CO 2 CH 3 R3 is H R4 is CH 2 CO 2 CH , CO 2 CH , CH 2 CO 2 H (or a salt thereof), CO 2 H (or a salt thereof). R5 is CH 3 R6 is CO 2 H, CO 2 Me or an amide M is In 113 , In 115 or a mixture of In 113 and In" 5 Z is a halide. acetate, or OH. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, In, La, Lu, Mo, Nd, Pb, Pd, Pr, Pt, Rh, Sb, Sc, Sm. Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb, Zn, or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Another family of compounds has the structure: where each R1-R13 is H, halide, alkyl, vinyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N"(CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), NR14R14, CN, OH, OR 14, CHO, COCH 3 , (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, CH(OH)CH 3 , CH(OR14)CH 3 (CH 2 ) n SR14, (CH,) n OR14 (where n = 1, 2, 3, 4, and R 14 is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO 2 R14 (where R14 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR14, (CH 2 ) n CON(R14) 2 , CO 2 R14, CONHR14, CONR14R14. SR14 (where R14 is a functional group less than or equal to 100000 daltons), SO X. SO 3 R14, SO 2 R14, SO 2 NHR14. SO 2 N(R14) 2 , SO 2 N(R14)-fχ- (where R14 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion): M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide . acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, suibstituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. Still another family of compounds has the following structure: where each of Rl and R2 is CO 2 R14 (where R14 is alkyl or aryl), CO 2 H (or a salt therof), SO 2 Ph, or CN; R3, R6, R8, and R12 are Me. R5 is CH=CH 2 , or CH(OR14)CH 3 (where R14 is alkyl or aryl) R4, R7, R13, R10 are H R9, Rl 1 are CH 2 CH 2 CO 2 R15 (where R15 is alkyl or H or a salt of the carboxylic acid) M is In , In 11S or a mixture of In 1 " and In 1"15 3 ; Z is a halide , acetate, OH. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Nd, Pb, Pd, Pr, Pt, Rh. Sb, Sc, Sm, Tb, Th, Ti, Tl, Tm, U, V. Y, Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Still another family of compounds has the following structure: where each of R 1 - R7 is CH 2 CH 3 . CH=CH 2 , CH=CHCH 2 N(CH,) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion). C(X) 2 C(X) 3 (where X is a halogen), CHO, OR8 or is a functional group less than or equal to 100000 daltons), CH 2 CO R8, CH 2 CONHR8, CH=CHCH 2 OH, CH=CHCH 2 OR8, CH(OH)CH 3 , CH(OR8)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR8R8, CN, OH, OR8, CHO, (CH,)„OH, (CH,) n SH, (CH,) n O-alkoxy, (CH,) n SR8. (CH 2 ) n OR8 (where n = 1, 2, 3, 4, and R8 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R8 (where R8 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHR8, (CH,) n CON(R8) 2 , CO 2 R8, CONHR8, CONR8R8, SR8 (where R8 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R8, SO 2 NHR8, SO 2 N(R8) 2 , SO 2 N(R8) 3 + X " (where R8 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; X is O, H 2 , (H, OH), S, (H, OR8) or a ketone protecting group; M is In 113 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Nd, Pb, Pd, Pr, Pt, Rh, Sb, Sc, Sm. Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al or Ru. Still another family of compounds has the following structure: wherein; Rl = COCH 3 R3 and R5 = H, CH R7 = H or OH R6 = Me or OH R4 = H or CO 2 CH 3 R2 = CO 2 R8 (where R8 is alkyl ) M is In 1 13 , In 1 15 or a mixture of In 113 and In 1 15 Z is a halide, acetate, or OH. X = O M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Nd, Pb, Pd, Pr, Pt, Rh, Sb, Sc, Sm. Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al or Ru. Another family of compounds has the structure: werein each of R1-R13 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) (where X is a halogen), NR14R14, CN, OH, OR 14, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, CH(OH)CH 3 , CH(OR14)CH 3 (CH,) n SR14, (CH,) n OR14 (where n = 1, 2, 3, 4, and R14 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R14 (where R14 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR14, (CH,) n CON(R14) 2 , CO 2 R14, CONHR14, CONR14R14, SR14 (where R14 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R14, SO 2 NHR14, SO 2 N(R14) 2 , SO 2 N(R14) 3 + X " (where R14 is a functional group less than or equal to 2000 daltons and X is a charge balancing ion); A, B, C, D are; C, N, O + , O, S, Te, P or combinations thereof; M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide, acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, In, La, Lu, Mo, Mg, Nd, Pb, Pd, Pr, Pt, Rh, Sb, Sc, Sn, Sm, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb, Zn, Zr. Still another family of compounds has the following structure: were each of R1-R13 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), NR14R14, CN, OH, OR14, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, CH(OH)CH 3 , CH(OR14)CH 3 , (CH,) n SR14, (CH,) n OR14 (where n = 1, 2, 3, 4, and R14 is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO,R14 (where R14 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR14, (CH,) n CON(R14) 2 , CO 2 R14, CONHR14, CONR14R14, SR14 (where R14 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R14, SO 2 NHR14. SO 2 N(R14) 2 , SO 2 N(R14) 3 + X " (where R14 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); A, B, C, D are; C, N, O + , O, S, Te, P or combinations thereof; M is In" 3 , In 115 or a mixture of In" 3 and In" 5 ; Z is a halide, acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pd, Pr, Pt, Rh, Sb, Sc, Sn, Sm, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb, Zn or Zr. Another family of compounds has the following structure: were each of R1-R13 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) (where X is a halogen), NR14R14, CN, OH, OR14, CHO. (CH,) n OH, (CH,) n SH, (CH 2 ) n O-alkoxy, CH(OH)CH 3 , CH(OR14)CH 3 (CH,) n SR14, (CH 2 ) n OR14 (where n = 1, 2, 3, 4, and R14 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R14 (where R14 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHR14, (CH 2 ) n CONH(R14) 2 , CO 2 R14, CONHR14, CONR14R14, SR14 (where R14 is a functional group less than or equal to 100000 daltons), SO 3 H, SO R14, SO 2 NHR14, SO 2 N(R14) 2 , SO 2 N(R14) 3 + X " (where R14 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 . In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, In, La, Lu, Mo, Mg, Nd, Pb, Pd, Pr, Pt, Rh, Sb, Sc, Sn, Sm, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb, Zn or Zr. Another family of compounds has the following structure: Where each of Rl and R2 is CO 2 R14 (where R14 is alkyl or aryl), CO 2 H (or a salt thereof), SO 2 Ph, CN or a combination thereof; Each of R3, R6, R8, R12 is Me. R5 is CH=CH 2 , or CH(OR14)CH 3 (where R14 is alkyl or aryl) Each of R4, R7, R13, R10 is H R9 and Rl l are CH 2 CH 2 CO 2 R15 (where R15 is alkyl or H or a salt of the carboxylic acid). M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 . Z is a halide , acetate, or OH. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, In, La, Lu, Mo, Mg, Nd, Pb, Pd, Pr, Pt, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb, Zn or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Another family of compounds has the following structure: where each of R1-R15 is H, halide, alkyl, vinyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) (where X is a halogen), NR16R16, CN, OH, OR16, CHO, COCH 3 , (CH 2 ) n OH, (CH,) n SH, (CH,) n O-alkoxy, SO 2 Ph, CH(OH)CH 3 , CH(OR14)CH 3 (CH,) n SR16, (CH,) n OR16 (where n = 1, 2, 3, 4, and R16 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R16 (where R16 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR16, (CH 2 ) n CON(R16) 2 , CO 2 R16, CONHR16, CONR16R16, SRI 6 (where R16 is a functional group less than or equal to 100000 daltons), SO 3 X, SO 3 R16, SO 2 NHR16, SO 2 N(R16) 2 , SO 2 N(R16) 3 + χ- (where R16 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, In, La, Lu, Mo, Mg, Nd, Pb, Pd, Pr, Pt, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb, Zn or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Another family of compounds has the following structure: where each of Rl, R2, R3 and R4 is CO 2 R16 (where R16 is alkyl or aryl), CO 2 H (or a salt thereof) or SO 2 Ph, CN; Each of R5, R8, R10 and R14 is Me. R7 is CH=CH 2 or CH(OR16)CH (where R16 is alkyl or aryl) Each of R6. R9, R12 and R15 is H Each of Rll and R13 is CH 2 CH 2 CO 2 R16 (where R16 is alkyl or H or a salt of the carboxylic acid), or an amide M is In" 3 , In 115 or a mixture of In" 3 and In" 5 Z is a halide , acetate, or OH. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd. Pb, Pd, Pr. Pt. Rh. Sb. Sc. Sm, Tb, Th, Ti. Tl, Tm, U, V, Y. Yb or Zr, preferably Pd. Pt, Ga, Al, Ru. Sn or Zn. Still another family of compounds has the following structure: Where each of R1-R13 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X ' (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), NR14R14, CN, OH, OR14, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, CH(OH)CH 3 , CH(OR14)CH 3 (CH 2 ) n SR14, (CH,) n OR14 (where n = 1, 2, 3, 4, and R14 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R14 (where R14 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR14, (CH,) n CON(R14) 2 , CO 2 R14, CONHR14, CONR14R14. SR14 (where R14 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R14. SO 2 NHR14, SO 2 N(R14) 2 , SO 2 N(R14) 3 + X " (where R14 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); A, B, C, D are; C, N, O\ O, S, Te, P or combinations thereof; M is In" 3 , In 115 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, In, La, Lu, Mo, Mg, Nd, Pb, Pd, Pr, Pt, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb, Zn or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Another family of compounds has the structure: Where each of R1-R14 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), NR15R15, CN, OH, OR15, CHO, (CH,) n OH, (CH,) n SH, (CH 2 ) n O-alkoxy, CH(OH)CH 3 , CH(OR15)CH 3 (CH,) n SR15, (CH,) n OR15 (where n = 1, 2, 3, 4, and R15 is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO,R15 (where R15 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHR15, (CH 2 ) n CON(R15) 2 , CO 2 R15, CONHR15, CONR15R15, SR15 (where R15 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R15, SO 2 NHR15, SO 2 N(R15) 2 , SO 2 N(R15) 3 + X " (where R15 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); A, B, C, D are; C, N, O + , O, S, Te, P or combinations thereof; M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pd, Pr, Pt, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb, Zn or Zr. Another family of compounds has the following structure: Where each of R1-R4 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X ' (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R5, CONHR5, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR5 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R5, CH 2 CONHR5, CH=CHCH 2 OH, CH=CHCH 2 OR5, CH(OH)CH 3 , CH(OR5)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR5R5, CN, OH, OR5, CHO, (CH 2 ) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH,) n SR5, (CH 2 ) n OR5 (where n = 1, 2, 3, 4, and R5 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R5 (where R5 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHR5, (CH,) n CON(R5) 2 , CO 2 R5, CONHR5, CONR5R5, SR5 (where R5 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R5, SO 2 NHR5, SO 2 N(R5) 2 , SO 2 N(R5) + X " (where R5 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecules or functional groups less than or equal to 100000 daltons; A and B are O, NH, NR5 or combinations thereof; X is , O, NR5 (where R5 is H, alkyl (1-10 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynylk, substituted alkynyl, an amino acid, an amino acid ester or a functional group less than or equal to 100000 daltons); M is In 113 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pd, Pr, Pt, Rh, Sb, Sc, Sm, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Another family of compounds has the following structure: Where each of Rl- R8 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R9, CONHR9, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR9 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R9, CH 2 CONHR9, CH=CHCH 2 OH, CH=CHCH 2 OR9, CH(OH)CH 3 , CH(OR9)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR9R9, CN, OH, OR9, CHO, (CH 2 ) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH,) n SR9, (CH, )n OR9 (where n = 1, 2, 3, 4, and R9 is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO 2 R9 (where R9 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHR9, (CH,) n CON(R9) 2 , CO R9, CONHR9, CONR9R9, SR9 (where R9 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R9, SO 2 NHR9, SO 2 N(R9) 2 , SO 2 N(R9) + X " (where R9 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; X is O, H 2 , (H, OH), (H, OR9), S, or a ketone protecting group; M is In" 3 , In 1 15 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkyinyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Ce, Co, Cr, Cu, Dy, Er, Fe, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pr, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Another family of compounds has the following structure: Where each of Rl- R6 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N"(CH 3 ) 3 X " (where X is a charge balancing ion) , C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R7, CONHR7, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR7 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R7, CH 2 CONHR7, CH=CHCH 2 OH, CH=CHCH 2 OR7, CH(OH)CH 3 , CH(OR7)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR7R7, CN, OH, OR7, CHO, (CH,) n OH, (CH 2 ) n SH, (CH,) n O- alkoxy, (CH,) n SR7, (CH,) n OR7 (where n = 1, 2, 3, 4, and R7 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R7 (where R7 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHR7, (CH 2 ) n CON(R7) 2 , CO 2 R7, CONHR7, CONR7R7, SR7 (where R7 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R7, SO 2 NHR7, SO 2 N(R7) 2 , SO 2 N(R7) 3 + X " (where R7 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; X is , O, NR7 (where R7 is H, alkyl (1-10 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, an amino acid, an amino acid ester or a functional group less than or equal to 100000 daltons); A and B are O, NH, NR7 or combinations thereof; M is In 1 '\ In 1 15 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, thereof; M is In 1 13 , In 1 15 or a mixture of In 1 13 and In 115 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Ce, Co, Cr, Cu, Dy, Er, Fe, Hf, Ho, La, Lu, Mo, Mg, Nd. Pb. Pr, Rh, Sb, Sc. Sm, Sn, Tb, Th, Ti, Tl. Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Another family of compounds has the following structure: wherein; Rl is CH=CH 2 , Et, CHO, or COCH 3 R2 is CO 2 CH 3 , CO 2 H, CO 2 R7 (R7 is an alkyl, phenyl), or an amide R3 is H R4 is Me Each of R5 and R6 is OH Each of A and B is O or NR7 ( R7 is alkyl). X is O or NR7 (R7 is alkyl, an amino acid, an alcohol containing group, or an ether containing group) M is In" 3 , In" 5 or a mixture of In 113 and In" 5 Z is a halide , acetate, or OH. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pr, Rh, Sb, Sc, Sm, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Another family of compounds has the following structure: where each of Rl- R6 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R7, CONHR7, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR7 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R7, CH 2 CONHR7. CH=CHCH 2 OH, CH=CHCH 2 OR7, CH(OH)CH 3 , CH(OR7)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR7R7, CN, O, S, NHR7, OH, OR7, CHO, (CH 2 ) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH 2 ) n SR7, (CH 2 )„OR7 (where n = 1, 2, 3, 4, and R7 is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO 2 R7 (where R7 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONR7, CO 2 R7, CONHR7, CONR10R7, SR7 (where R7 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R7. SO 2 NHR7, SO 2 N(R7) 2 , SO 2 N(R7) 3 + X " (where R7 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; X is O, H 2 , (H, OH), (H, OR8) S, or a ketone protecting group; M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu. Mo, Mg, Nd, Pb, Pr, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn,. Another family of compounds has the following structure: wherein; Rl is CH=CH 2 , Et, CHO, or COCH R2 is CO 2 CH 3 , CO 2 H, CO 2 R7 (R7 is an alkyl or phenyl group), or an amide R3 is H R4 is H or CO 2 CH 3 R5 is O or NR7 (where R7 is alkyl) R6 is Me X is O M is In" 3 , In 1 15 or a mixture of In" 3 and In" 5 Z is a halide . acetate or OH. M can also be Ag, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pr, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Another family of compounds has the following structure: where each of Rl- R8 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R9, CONHR9, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR9 or is a functional group less than or equal to 100000 daltons), CH 2 CO R9, CH 2 CONHR9, CH=CHCH 2 OH, CH=CHCH 2 OR9, CH(OH)CH 3 , CH(OR9)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, 5 alkynyl, substituted alkynyl, amide, ester, NR9R9, CN, O, S, NHR9, OH, OR9, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH,) n SR9, (CH,) n OR9 (where n = 1, 2, 3, 4, and R9 is a functional groups less than or equal to 100000 daltons), (CH,) n CO,R9 (where R9 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHR9, 0 (CH,) n CON(R9) 2 , CO 2 R9, CONHR9, CONR10R9, SR9 (where R9 is a functional groups less than or equal to 100000 daltons), SO 3 H. SO 3 R9, SO 2 NHR9, SO 2 N(R9) 2 , SO 2 N(R9) 3 + X " (where R9 is a functional groups less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; M is In" 3 , In 1 15 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, 5 OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, a protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pr, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. 0 Still another family of compounds has the following structure: wherein; 5 R 1 is CH=CH 2 , Et, CHO, or COCH 3 R5 is O or NR7 (where R7 is alkyl) R7 is Me R3 is H R4 and R8 are H, CO 2 CH 3 , CO 2 H (or a salt thereof), CO 2 R7 (R7 is an alkyl or phenyl group), an amide, CH 2 CO 2 CH 3 , CH 2 CO 2 H (or a salt thereof), CO 2 R9 (R9 is an alkyl or a phenyl group), or an amide R2 is CO 2 CH 3 , CO 2 H, CO 2 R9 (R9 is an alkyl or phenyl group), or an amide M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 Z is a halide , acetate, or OH. M can also be Ag, Ce. Co, Cr, Cu. Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pr, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al. Ru, Sn or Zn. Another family of compounds has the following structure: where each of Rl- R5 is CH 2 CH , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen). CHO, COCH 3 , CO 2 H, CO 2 R6, CONHR6, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR6 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R6, CH 2 CONHR6, CH=CHCH 2 OH, CH=CHCH 2 OR8, CH(OH)CH 3 , CH(OR6)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR6R6, CN, O, S, NHR6, OH, OR6, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH,) n SR6, (CH,) n OR6 (where n = 1, 2, 3, 4, and R6 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R6 (where R6 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l , 2, 3, 4), (CH,) n CONR6, CO 2 R6, CONHR6, CONR6R6, SR6 (where R6 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R6, SO 2 NHR6, SO 2 N(R6) 2 , SO 2 N(R6) 3 + X " (where R6 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R6, SO 2 NHR6, SO 2 N(R6) 2 , SO 2 N(R6) 3 + X ' (where R6 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; X is O, NR6 (where R6 is H, alkyl (1-10 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, an amino acid, an amino acid ester or a functional group less than or equal to 100000 daltons); A and B are O, NH, NR6 or combinations thereof; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pr, Rh, Sb. Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y. Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, S or Zn. Another family of compounds has the following structure: Wherein: Each of A and B is O or NR6 (where R6 is an alkyl or phenyl group) Rl is CH=CH 2 , Et, CHO, or COCH 3 R4 is O or NR6 (where R6 is alkyl) R5 is Me R3 is H R2 is CO 2 CH 3 , CO 2 H, CO 2 R6 (R6 is an alkyl or phenyl group), or an amide X is O, NR6 (R6 is alkyl, an amino acid, an alcohol containing group, or an ether containing group) M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 Z is a halide , acetate, OH. M can also be Ag, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pr, Rh, Sb, Sc, Sm. Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Another family of compounds has the following structure: Where each of Rl- R6 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R7, CONHR7, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR7 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R7, CH 2 CONHR7, CH=CHCH 2 OH, CH=CHCH 2 OR7, CH(OH)CH 3 , CH(OR7)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR7R7, CN, O, S, NHR7, OH, OR7, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH,) n SR7, (CH,) n OR7 (where n = 1, 2, 3, 4, and R7 is a functional groups less than or equal to 100000 daltons), (CH,) n CO,R7 (where R7 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONR7, CO 2 R7, CONHR7, CONR7R7, SR7 (where R7 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R7, SO 2 NHR7, SO 2 N(R7) 2 , SO 2 N(R7) 3 + X- (where R7 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; X is O, H 2 , (H, OH), (H, OR7), S, or a ketone protecting group; M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecules or functional group less than or equal to 100000 daltons. M can also be Ag, Ce, Co, Cr, Cu, Dy, Er. Fe, Ga. Hf, Ho, La, Lu. Mo, Mg, Nd, Pb. Pr, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Another family of compounds has the structure: wherein; Rl is CH=CH 2 , Et, CHO, or COCH 3 R6 is O or NR7 (where R7 is an alkyl group) R5 is Me R3 is H R4 is H or CO 2 CH 3 R2 is CO 2 CH 3 , CO 2 H, CO 2 R7 (R7 is an alkyl, phenyl), or an amide X is O M is In 1 13 . In 1 15 or a mixture of In" 3 and In 1 15 Z is a halide , acetate, or OH. M can also be Ag, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pr, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Another family of compounds has the structure: Where each of Rl- R7 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R8, CONHR8, CH=CHCHO, CH 2 Y,(where Y = H, halogen, OH, OR8 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R8, CH 2 CONHR8, CH=CHCH 2 OH, CH=CHCH 2 OR8, CH(OH)CH 3 , CH(OR8)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR8R8, CN, O, S, NHR8, OH, OR8, CHO, (CH2) n OH, (CH2) n SH, (CH2) n O-alkoxy, (CH2) n SR8, (CH2) n OR8 (where n = 1, 2, 3, 4, and R8 is a functional groups less than or equal to 100000 daltons), (CH2)nCO2R8 (where R8 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl,substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH2) n CONR8, CO 2 R8, CONHR8, CONR8R8, SR8 (where R8 is a functional groups less than or equal to 100000 daltons), SO 3 H, SO 3 R8, SO 2 NHR8, SO 2 N(R8) 2 , SO N(R8) 3 + X " (where R8 is a functional groups less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecules or functional groups less than or equal to 100000 daltons; M is In" 3 , In" 5 or a mixture of In" 3 and In 1 15 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecules or functional groups less than or equal to 100000 daltons. Another family of compounds has the structure: wherein; Rl is CH=CH 2 , Et, CHO, or COCH 3 R6 is O, or NR8 (where R8 is alkyl) R5 is Me R3 is H R4 and R7 are H, CO 2 CH , CO 2 H (or a salt thereof), CO 2 R8 (R8 is alkyl or phenyl), an amide, CH 2 CO 2 CH 3 , CH 2 CO 2 H (or a salt thereof), CO 2 R8 (R8 is an alkyl or phenyl group) R2 is CO 2 CH 3 . CO 2 H, CO 2 R8 (R8 is alkyl or phenyl), or an amide M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 Z is a halide , acetate, OH. M can also be Pd Ag, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pr, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Another family of compounds has the following structure: Wherein: Rl is CH=CH 2 , Et, CHO or COCH 3 R4 is Me R3 is H R2 is CO 2 CH 3 , CO 2 H, CO 2 R5 (R5 is alkyl or phenyl), or an amide Each of A and B is O or NR5 ( R5 is alkyl) X is O, NR5 (R5 is alkyl. an amino acid, an alcohol containing group, or an ether containing group) M is In 1 13 , In" 5 or a mixture of In" 3 and In" 5 . M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pr, Rh, Sb, Sc, Sm, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Another family of compounds has the structure: Wherein: Rl is CH=CH 2 , Et, CHO or COCH 3 Each of R6 and R7 is H or OH R5 is Me R4 is CO 2 CH 3 , CO 2 H, CO 2 R9 (R9 is an alkyl or a phenyl group), an amide, CH 2 CO 2 CH 3 , CH 2 CO 2 H, or CH 2 CO 2 R9 (R9 is an alkyl or a phenyl group). R3 is H each of R2 and R8 is CO 2 CH 3 , CO 2 H, CO 2 R9 (R9 is an alkyl or a phenyl group), or an amide M is In" 3 , In 1 15 or a mixture of In" 3 and In" 5 Z is a halide , acetate, or OH. M can also be Ag, Ce, Co, Cr, Cu, Dy, Er, Fe, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pr, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Still another family of compounds has the structure: wherein each of R1-R5 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R6, CONHR6, CH=CHCHO, CH 2 Y, (where Y = H, halogen. OH or OR6 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R6, CH 2 CONHR6, CH=CHCH 2 OH, CH=CHCH 2 OR6. CH(OH)CH 3 , CH(OR6)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR6R6, CN, O, S, NHR6, OH, OR6, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH,) n SR6, (CH 2 ) n OR6 (where n = 1, 2, 3, 4, and R6 is a functional group less than or equal to 100000 daltons), (CH,) n C ,R6 (where R6 is H. a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl. alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONR6, CO 2 R6, CONHR6, CONR6R6, SR6 (where R6 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R6, SO 2 NHR6, SO 2 N(R6) 2 , SO 2 N(R6) 3 + X " (where R6 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; : A and B are O, NH, NR6 or combinations thereof; X is , O, NR6 (where R6 is H. alkyl ( 1-10 carbons), aryl. substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, an amino acid, an amino acid ester or a functional group less than or equal to 100000 daltons); M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Ce, Co. Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pr, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Still another family of compounds has the structure: wherein: Rl is CH=CH 2 , Et, CHO or COCH 3 R5 is O or NR6 (where R6 is alkyl) R4 is Me R3 is H R2 is CO 2 CH 3 , CO 2 H, CO 2 R5 (R5 is alkyl or phenyl), or an amide A and B are O or NR6 (R6 is an alkyl or a phenyl group) X is O, NR6 (R6 is alkyl), an amino acid, an alcohol containing group, or an ether or amine containing group M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 Z is a halide. acetate, or OH. M can also be Ag, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd. Pb. Pr or Rh, preferably Ga, Al, Ru, Sn or Zn. Still another family of compounds has the structure: Wherein each of Rl- R24 is CH 2 CH 3 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), CH=CH 2 , C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R25, CONHR25, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR25 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R25, CH 2 CONHR25, CH=CHCH 2 OH, CH=CHCH 2 OR25, CH(OH)CH 3 , CH(OR25)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR25R25, CN, O, S, NHR25, OH, OR25, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH,) n SR25, (CH 2 ) n OR25 (where n = 1, 2, 3, 4, and R25 is a functional group less than or equal to 100000 daltons), (CH,) n CO2R25 (where R25 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CON(R25) 2 , (CH 2 ) n CONHR25, CO 2 R25, CONHR25, CONR25R25, SR25 (where R25 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R25, SO 2 NHR25, SO 2 N(R25) , SO 2 N(R25) 3 + X " (where R25 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; A, B, C, D are: C, N, O + , O, S, Te, P, N + (R25)X " (where R25 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), or combinations thereof; M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Pd or Ga. Yet another family of compounds has the structure: Wherein each of CH=CHCH 2 N CH ) ? X " (where X is a charge balancing ion). C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R9, CONHR9, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR9 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R9, CH 2 CONHR9, CH=CHCH 2 OH, CH=CHCH 2 OR9, CH(OH)CH 3 , CH(OR9)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR9R9, CN, O, S, NHR9, OH, OR9, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH 2 ) n SR9, (CH 2 ) n OR9 (where n = 1, 2, 3, 4, and R9 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R9 (where R9 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl. substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR9, (CH,) n CON(R9) 2 , CO 2 R9, CONHR9, CONR9R9, SR9 (where R9 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R9, SO 2 NHR9, SO 2 N(R9) 2 , SO 2 N(R9) 3 + X " (where R9 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons. A, B, C, D are; C, N, O + , O, S, Te, P, N + (R9)X " (where R9 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), or combinations thereof.; M is In" 3 , In" 5 or a mixture of In" 3 and In 115 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons; X is O, NR9 (where R9 is H, alkyl (1-10 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, an amino acid, an amino acid ester or a functional group less than or equal to 100000 daltons). M can also be Pd or Ga. Yet another family of compounds has the structure: wherein each of R1-R22 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R23, CONHR23, CH=CHCHO. CH 2 Y. (where Y = H, halogen, OH, OR23 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R23, CH 2 CONHR23, CH=CHCH 2 OH, CH=CHCH 2 OR23, CH(OH)CH 3 , CH(OR23)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR23R23, CN, O, S, NHR23. OH, OR23, CHO, (CH,) n OH, (CH 2 ) n SH, (CH,) n O-alkoxy, (CH,) n SR23, (CH,) n OR23 (where n = 1, 2, 3, 4, and R23 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R23 (where R23 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR23, (CH,) n CON(R23) 2 , CO 2 R23, CONHR23, CONR23R23, SR23 (where R23 is a functional group less than or equal to 100000 daltons), SO 3 H, SO R23, SO 2 NHR23, SO 2 N(R23) 2 , SO 2 N(R23) 3 + X " (where R23 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; A, B, C, D, E and F are C, N. O + , O, S, Te. P, N"(R23)X " (where R23 is a functional group less than or equal to 2000 daltons and X is a charge balancing ion), or combinations thereof; M is In 1 13 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Pd or Ga. Another family of compounds has the structure: wherein each of R1-R18 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X ' (where X is a charge balancing ion), C(X) 2 C(X) (where X is a halogen), CHO. COCH 3 , CO 2 H, CO 2 R19, CONHR19, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH. OR 19 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R19, CH 2 CONHR19, CH=CHCH 2 OH, CH=CHCH 2 OR19, CH(OH)CH 3 , CH(OR19)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR19R19, CN, O, S, NHR19, OH, OR19, CHO, (CH 2 ) n OH, (CH,) n SH, (CH 2 ) n O-alkoxy, (CH,) n SR19, or (CH,) n OR19 (where n = 1, 2, 3, 4, and R19 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R19 (where R19 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR19, (CH 2 ) n CON(R19) 2 , CO 2 R19, CONHR19, CONR19R19, SR19 (where R19 is a functional group less than or equal to 2000 daltons), SO 3 H, SO 3 R19, SO 2 NHR19, SO 2 N(R19) 2 , SO 2 N(R19) 3 + X " (where R19 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; A, B, C, D, E, F are CH, N, O + , O, S, Te, P, N + (R19)X " (where R19 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), or combinations thereof; M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Pd or Ga. Another family of compounds has the structure: wherein each of R1-R20 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R21, CONHR21, CH=CHCHO. CH 2 Y, (where Y = H, halogen, OH, OR21 or is a functional group less than or equal to 100000 daltons). CH 2 CO 2 R21, CH 2 CONHR21, CH=CHCH 2 OH, CH=CHCH 2 OR21. CH(OH)CH 3 , CH(OR21)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR21R21, CN, O, S, NHR21, OH, OR21, CHO, (CH 2 ) n OH, (CH 2 ) n SH, (CH 2 ) n O-alkoxy, (CH 2 ) n SR21, (CH,) n OR21 (where n = 1, 2, 3, 4, and R21 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R21 (where R21 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR21, (CH,) n CON(R21) 2 , CO 2 R21, CONHR21, CONR21R21, SR21 (where R21 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R21, SO 2 NHR21, SO 2 N(R21) 2 , SO 2 N(R21) 3 + X " (where R21 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; A, B, C, D, E, F are: C, N, O + , O, S, Te, P, N + (R21)X ~ (where R21 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), or combinations thereof; M is In" 3 , In 1 15 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Pd or Ga. Still another family of compounds has the following structure: where each of R1-R24 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R25, CONHR25, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR25 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R25, CH 2 CONHR25, CH=CHCH 2 OH, CH=CHCH 2 OR25, CH(OH)CH 3 , CH(OR25)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR25R25, CN, O, S, NHR25, OH, OR25, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH,) n SR25, (CH,) n OR25 (where n = 1, 2, 3, 4, and R25 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R25 (where R25 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR25, (CH 2 ) n CON(R25) 2 , CO 2 R25, CONHR25, CONR25R25, SR25 (where R25 is a functional group less than or equal to 100000 daltons), SO H, SO 3 R25, SO 2 NHR25, SO 2 N(R25) 2 , SO 2 N(R25) 3 + X " (where R25 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; A, B. C, D, E, F are C, N, O + , O, S, Te, P, N + (R25)X " (where R25 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), or combinations thereof; M is In" 3 , In 1 15 or a mixture of In" 3 and In" 5 ; Z is a halide . acetate. OH. alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Pd or Ga. Still another family of compounds has the structure: where each of R1-R32 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R33, CONHR33. CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR33 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R33, CH 2 CONHR33, CH=CHCH 2 OH, CH=CHCH 2 OR33, CH(OH)CH 3 , CH(OR33)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR33R33, CN, O, S, NHR33, OH, OR33, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH,) n SR33, (CH,) n OR33 (where n = 1, 2, 3, 4, and R33 is a functional group less than or equal to 100000 daltons), (CH,) n CO 2 R33 (where R33 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR33, (CH,) n CON(R33) 2 , CO 2 R33, CONHR33, CONR33R33, SR33 (where R33 is a functional group less than or equal to 100000 daltons), SO 3 H, SO R33, SO 2 NHR33, SO 2 N(R33) 2 , SO 2 N(R33) 3 + X " (where R33 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; A, B, C are; C. N, O + , O, S, Te, P, N + (R33)X " (where R33 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), or combinations thereof; M is In" 3 , In 1 15 or a mixture of In 113 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Pd or Ga. Still another family of compounds has the structure: where each of R1-R18 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X ' (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R19, CONHR19, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR19 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R19, CH 2 CONHR19, CH=CHCH 2 OH, CH=CHCH 2 OR19, CH(OH)CH 3 , CH(OR19)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR19R19, CN, O, S, NHR19, OH, OR19, CHO, (CH 2 ) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH 2 ) n SR19, (CH,) n OR19 (where n = 1, 2, 3, 4, and R19 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R19 (where R19 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR19, (CH,) n CON(R19) 2 , CO 2 R19, CONHR19, CONR10R19, SR19 (where R19 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R19, SO 2 NHR19, SO 2 N(R19) 2 , SO 2 N(R19) 3 + X " (where R19 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons. U, V, X, Y are C, N, O + , O, S, Te, P, N + (R19)X " (where R 19 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), or combinations thereof; M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl. substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Pd or Ga. Another family of compounds has the structure: where each of R1-R9 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R10, CONHRIO, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR 10 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R10, CH 2 CONHR10, CH=CHCH 2 OH, CH=CHCH 2 OR10, CH(OH)CH 3 , CH(OR10)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR10R10, CN, OH, OR10, CHO, (CH 2 ) n OH, (CH 2 ) n SH, (CH,) n O-alkoxy, (CH,) n SR10, (CH,) n OR10 (where n = 1, 2, 3, 4, and R10 is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO,R10 (where R10 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHR10, (CH,) n CON(R10) 2 , CO 2 R10, CONHRIO, CONR10R10, SR10 (where R10 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R10, SO 2 NHR10, SO 2 N(R10) 2 , SO 2 N(R10) + X " (where R10 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; M is In 113 , In" 5 or a mixture of In" 3 and In" 5 . M can also be Ga. Still another family of compounds has the structure: where each of R1-R12 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R13, CONHR13, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR13 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R13, CH 2 CONHR13, CH=CHCH 2 OH, CH=CHCH 2 OR13, CH(OH)CH 3 , CH(OR13)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR13R13, CN, OH. OR13, CHO, (CH,) n OH, (CH,) n SH. (CH,) n O-alkoxy, (CH,) n SR13, (CH,) n OR13 (where n = 1. 2, 3. 4. and R13 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R13 (where R13 is H, a physiologically acceptable salt,- alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHR13, (CH,) n CON(R13) 2 , CO 2 R13, CONHR13, CONR13R13, SR13 (where R13 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R13, SO 2 NHR13, SO 2 N(R13) 2 , SO 2 N(R13) 3 + X " (where R13 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Pd or Ga. Yet another family of compounds has the structure: Where each of Rl- R15 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R16, CONHR16, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR16 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R16, CH 2 CONHR16, CH=CHCH 2 OH, CH=CHCH 2 OR16, CH(OH)CH 3 , CH(OR16)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR16R16, CN, O, S, NHR16, OH, OR16, CHO, (CH,) n OH, (CH 2 ) n SH, (CH 2 ) n O-alkoxy, (CH,) n SR16, (CH,) n OR16 (where n = 1, 2, 3, 4, and R16 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R16 (where R16 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR16, (CH,) n CON(R16) 2 , CO 2 R16, CONHR16, CONR16R16, SR16 (where R16 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R16, SO 2 NHR16, SO 2 N(R16) 2 , SO 2 N(R16) 3 + X " (where R16 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), I 1 "\ protein or biomolecule or functional group less than or equal to 100000 daltons; M is In , In 1 15 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be M is Ag, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pr or Rh, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Yet another family of compounds has the following structure: where each of R 1 -R 14 is CH 2 CH 3 , CH=CH 2 , CH=CHCH N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R15, CONHR15, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR15 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R15, CH 2 CONHR15, CH=CHCH 2 OH, CH=CHCH 2 OR15, CH(OH)CH 3 , CH(OR15)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR15R15, CN, O, S, NHR15, OH, OR15, CHO, (CH,) n OH, (CH,) n SH, (CH 2 ) n O-alkoxy, (CH 2 ) n SR15, (CH 2 ) n OR15 (where n = 1, 2, 3, 4, and R 15 is a functional group less than or equal to 100000 daltons), (CH,) n CO 2 R15 (where R15 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2. 3, 4), (CH,) n CONHR15, (CH,) n CON(R15) 2 , CO 2 R15, CONHR15, CONR15R15, SR15 (where R15 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R15, SO 2 NHR15, SO 2 N(R15) 2 , SO 2 N(R15) 3 + X " (where R15 is a functional groups less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; M is In 1 13 , In 1 15 or a mixture of In 1 13 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pr or Rh, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Still another family of compounds has the following stucture: where each of R1-R15 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H. CO 2 R16, CONHR16, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR16 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R16, CH 2 CONHR16, CH=CHCH 2 OH, CH=CHCH 2 OR16, CH(OH)CH 3 , CH(OR16)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR16R16, CN, O, S, NHR16, OH, OR16, CHO, (CH 2 ) n OH, (CH 2 ) n SH, (CH 2 ) n O-alkoxy, (CH,)„SR16, (CH,) n OR16 (where n = 1, 2, 3, 4, and R16 is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO 2 R16 (where R16 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR16, (CH,) n CON(R16) 2 , CO 2 R16, CONHR16, CONR16R16, SR16 (where R16 is a functional group less than or equal to 100000 daltons), SO 3 H, SO R16, SO 2 NHR16, SO 2 N(R16) 2 , SO 2 N(R16) 3 + X " (where R16 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; M is In 1 13 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Ce. Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo. Mg, Nd, Pb, Pr, or Rh, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Yet other families of compounds have the following structure: Where each of R1-R12 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R13, CONHR13, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR13 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R13, CH 2 CONHR13, CH=CHCH 2 OH, CH=CHCH 2 OR13, CH(OH)CH 3 , CH(OR13)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR13R13, CN, O, S, NHR13, OH, OR13, CHO, (CH 2 ) n OH, (CH,) n SH, (CH 2 ) n O-alkoxy, (CH 2 ) n SR13, (CH,) n OR13 (where n = 1, 2, 3, 4, and R13 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R13 (where R13 is H, a physiologically acceptable salt, alkyl ( 1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2. 3, 4), (CH,) n CONHR13, (CH,) n CON(R13) 2 , CO 2 R13. CONHR13, CONR13R13, SR13 (where R13 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R13, SO 2 NHR13, SO 2 N(R13) 2 , SO 2 N(R13) 3 + X " (where R13 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; M is In 113 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Pd, Pt, Ga or Al. Another family of compounds has the following structure: Where each of R1-R14 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH , CO 2 H, CO 2 R15. CONHR15, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR15 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R15, CH 2 CONHR15, CH=CHCH 2 OH, CH=CHCH 2 OR15, CH(OH)CH 3 , CH(OR15)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR15R15, CN, O, S, NHR15, OH, OR15, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH,) n SR15, (CH,) n OR15 (where n = 1, 2, 3, 4, and R15 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R15 (where R15 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR15, (CH 2 ) n CON(R15) 2 , CO 2 R15, CONHR15, CONR15R15, SR15 (where R15 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R15, SO 2 NHR15, SO 2 N(R15) 2 , SO 2 N(R15) 3 + χ- (where R15 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; A, B, C, D are; C, N, O + , O, S, Te, P, N + (R15)X ' (where R15 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), or combinations thereof; M is In 113 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Pd, Pt, Ga or Al. Yet another family of compounds has the following structure: Where each of R1-R18 is CH 2 CH , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R19, CONHR19, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH. OR 19 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R19, CH 2 CONHR19, CH=CHCH 2 OH, CH=CHCH 2 OR19, CH(OH)CH 3 , CH(OR19)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR19R19, CN, O, S, NHR19, OH, OR19, CHO, (CH 2 ) n OH, (CH 2 ) n SH, (CH 2 ) n O-alkoxy, (CH 2 ) n SR19, (CH,) n OR19 (where n = 1, 2, 3, 4, and R19 is a functional group less than or equal to ' 100000 daltons), (CH,) n CO,R19 (where R19 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl. and n=l. 2, 3, 4), (CH,) n CONHR19, (CH,) n CON(R19) 2 , CO 2 R19, CONHR19, CONR19R19, SR19 (where R19 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R19, SO 2 NHR19, SO 2 N(R19) 2 , SO 2 N(R19) 3 + X " (where R19 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; A, B, C, D, E , F, G, H are; C, N, O + , O, S, Te, P, N + (R19)X " (where R19 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion) or combinations thereof; M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Pd, Pt, Ga or Al. Still another family of compounds has the following structure: Where each of R1-R12 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 X, CH=CHCH 2 N"(CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen). CHO, COCH 3 , CO 2 H. CO 2 R13, CONHR13, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR13 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R13, CH 2 CONHR13, CH=CHCH 2 OH, CH=CHCH 2 OR13, CH(OH)CH 3 , CH(OR13)CH , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR13R13, CN, O, S, NHR13, OH, OR13, CHO, (CH 2 ) n OH, (CH 2 ) n SH, (CH 2 ) n O-alkoxy, (CH 2 ) n SR13, (CH,) n OR13 (where n = 1, 2, 3, 4, and R13 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R13 (where R13 is H, a physiologically acceptable salt, alkyl ( 1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl. alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR13, (CH,) n CON(R13) 2 , CO 2 R13, CONHR13, CONR13R13, SR13 (where R13 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R13, SO 2 NHR13, SO 2 N(R13) 2 , SO 2 N(R13).-TX " (where R13 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion). protein or biomolecule or functional group less than or equal to 100000 daltons; Z is halide, acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. Another family of compounds has the following structure: where each of R1-R15 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion). C(X) 2 C(X) (where X is a halogen), CHO, COCH , CO 2 H, CO 2 R16, CONHR16, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR16 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R16, CH 2 CONHR16, CH=CHCH 2 OH, CH=CHCH 2 OR16, CH(OH)CH 3 , CH(OR16)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR16R16, CN, O, S, NHR16. OH, OR16, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH 2 ) n SR16, (CH 2 ) n OR16 (where n = 1, 2. 3, 4, and R16 is a functional group less than or equal to 100000 daltons), (CH,) n CO 2 R16 (where R16 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR16, (CH,) n CON(R16) 2 , CO 2 R16, CONHR16, CONR16R16, SR16 (where R16 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R16, SO 2 NHR16, SO 2 N(R16) 2 , SO 2 N(R16) 3 + X " (where R16 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; Z is halide, acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. Still another family of compounds has the following structure: where each of R1-R14 can be CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO. COCH 3 , CO 2 H, CO 2 R15, CONHR15, CH=CHCHO. CH 2 Y. (where Y = H, halogen, OH, OR15 or is a functional group less than or equal to 100000 daltons). CH 2 CO 2 R15, CH 2 CONHR15, CH=CHCH 2 OH, CH=CHCH 2 OR15, CH(OH)CH 3 , CH(OR15)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR15R15, CN, O, S, NHR15, OH, OR15, CHO, (CH 2 ) n OH, (CH 2 )„SH, (CH 2 ) n O-alkoxy, (CH 2 ) n SR15, (CH ^ ) n OR15 (where n = 1, 2, 3, 4, and R15 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R15 (where R15 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR15, (CH 2 ) n CON(R15) 2 , CO 2 R15, CONHR15, CONR15R15, SRI 5 (where R15 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R15, SO 2 NHR16, SO 2 N(R15) 2 , SO 2 N(R15) 3 "X " (where R15 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; M is In" 3 , In" 5 or a mixture of In 113 and In" 5 ; Z is a halide, acetate, OH, alkyl. aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. M can also be Ag, Ce, Co, Cr, Cu, Dy, Er, Fe, Ga, Hf, Ho, La, Lu, Mo, Mg, Nd, Pb, Pr, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, preferably Pd, Pt, Ga, Al, Ru, Sn or Zn. Still another family of compounds has the formula: Where In is In" 3 , In" 5 , or a mixture of In" 3 and In 115 , each of R1-R12 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R13, CONHR13, CH=CHCHO, CH 2 Y. (where Y = H. halogen. OH. OR13 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R13, CH 2 CONHR13, CH=CHCH OH, CH=CHCH 2 OR13. CH(OH)CH 3 , CH(OR13)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR13R13, CN, O, S, NHR13, OH, OR13, CHO, (CH 2 ) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH 2 ) n SR13, (CH 2 ) n OR13 (where n = 1, 2, 3, 4, and R13 is a functional group less than or equal to 100000 daltons), (CH,) n CO,R13 (where R13 is H. a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR13. (CH 2 ) n CON(R13) 2 , CO 2 R13, CONHR13, CONR13R13, SR13 (where R13 is a functional groups less than or equal to 100000 daltons), SO 3 H, SO 3 R13, SO 2 NHR13, SO 2 N(R13) 2 , SO 2 N(R13) 3 + X " (where R13 is a functional groups less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; Z is halide, acetate, OH, alkyl, aryl, substituted aryl. alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional groups less than or equal to 100000 daltons. Two other families of compounds have the structures of Compound I and II, below: wherein M is In" 3 , In' 15 or a mixture of In 113 and In Rl, R2 and R3 can be the same or different, and each is CO 2 H, CO 2 R4, CONR4, CH 3 Y', CONR4R4. NH 2 , N(R4) 2 , or N(R4) 3 + Z " , where Y' is halogen, OH, OR4, or a functional group having a molecular weight equal to or less than 100,000 daltons, R4 is a functional group having a molecular weight equal to or less than 100,000 daltons, and Z is a physiologically acceptable charge balancing ion. with the proviso that R4 is not a mono- or di-carboxylic acid of an amino acid, R5 is a methylene group or an ethylene group, X is H, vinyl, ethyl, acetyl or formyl, and Y is methyl or formyl. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy. Er, Eu, Fe, Ga, Gd, Hf, Ho, In, La. Lu, Mn, Mo, Nd, Pb, Pd, Pr, Pt, Rh. Sb, Sc, Sm, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, and preferably is In, Pd, or Pt. In still another aspect, the invention is a free base or a metal complex having the structure of one of Compounds III and IV, below: Compound III Compound IV wherein M is 2H or a metal cation, Rl, R2 and R3 can be the same or different, and each is CO 2 H, CO 2 R4, CONR4, CH 3 Y', CONR4R4, NH 2 , N(R4) 2 , N(R4) 3 + Z " , or CONHR6OR7 where R6 is a bivalent moiety composed of a number, n, of alkylene groups and (n minus 1) oxygens, each oxygen linking two alkylene groups through an ether linkage, CONHR6OR7 where R6 is a bivalent moiety composed of a number, n, of alkylene groups and (n minus 1) oxygens, each oxygen linking two alkylene groups through an ether linkage, and R7 is alkyl, and Z is a physiologically acceptable charge balancing ion, with the proviso that there is at least one R6 group in the structure, X is H, vinyl, ethyl, acetyl or formyl, and Y is methyl or formyl. In the foregoing definition, and elsewhere herein, the term "alkylene" means a bivalent radical derived from an alkane with the free valences on different carbon carbon atoms. i.e., -C„H n - Preferably, M is Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Eu, Fe, Ga, Gd, Hf, Ho, In. La, Lu, Mn, Mo, Nd. Pb, Pd, Pr, Pt, Rh, Sb. Sc, Sm, Sn, Tb, Th. Ti, Tl, Tm, U, V, Y, Yb, Zn or Zr, most desirably Zn, Sn, In . 1 13, I τn„ HS, a mixture of In i"n- a. nd In , 1 1 15 , Pd, or Pt. In still another aspect, the invention is a metal complex having the structure of one of Compound V and VI. below: Compound V Compound VI wherein M is 2H, In 113 , In 115 or a mixture of In 113 and In 115 Rl, R2 and R3 can be the same or different, and each is X is H, vinyl, ethyl, acetyl or formyl, and Y is methyl or formyl. M can also be Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Eu, Fe, Ga, Gd, Hf, Ho, In, La, Lu, Mn, Mo, Nd, Pb, Pd, Pr, Pt, Rh, Sb, Sc, Sm, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb or Zr, most desirably Pd, Pt, In" 3 , In 1 15 or a mixture of In 113 and In" 5 . In the foregoing discussion of the invention and in the following claims, the term functional group having a molecular weight equal to or less than 100,000 daltons has been used. This term refers to such groups as monoclonal antibodies, proteins, saccharides, oligomeric nucleosides, peptides and the like. The terms alkyl, alkenyl, alkynyl, substituted alkenyl, substituted alkynyl and aryl, when used herein and in the appended claims to refer to substituents, preferably mean groups having 1 to 10, 2 to 10, 2 to 10, 2 to 10, 2 to 10 and 6 to 10 carbons, respectively. It will be apparent that various changes and modifications can be made from the specific disclosure of the invention set forth herein without departing from the spirit and scope thereof as defined in the following claims.

Claims: I claim: 1. A phototherapeutic compound composed of an atom of In" 3 or of In 115 complexed with the inner nitrogens of a pyrrolic core composed of at least two pyrroles whose pyrrole linking atoms may be carbon or nitrogen or combinations thereof, with the proviso that fully unsaturated poφhyrins having the structures: where Rl, R2, R4 and R6 are methyl, R8, RIO, Rl 1 and R12 are hydrogen, and R7 and R8 are CH 2 CH 2 COR13 (where R13 is a moiety which results from the removal of H from an amino acid) and where Rl is CH(OR)Me, R is alkyl, R2 is a residue derived by removing H from an amino acid, and M is 2H, Ga, Zn, Pd, In or Sn are excluded. 2. A phototherapeutic compound as claimed in claim 1 wherein the core is a tetrapyrrolic core. 3. A phototherapeutic compound as claimed in claim 2 wherein the core is a dihydro or tetrahydro tetrapyrrolic core. 4. A phototherapeutic compound as claimed in claim 3 which has a tetrapyrrolic core whose linking atoms are carbon. 1 1 5. A phototherapeutic compound as claimed in claim 4 having the structure of one of Compound 1 and Compound II, below: wherein M is In .1 1 1 "3 Z. , In .1'1 l 5 3 Z, or a mixture of In" 3 Z and In" 5 Z, Rl, R2 and R3 can be the same or different, and each is CO 2 H, CO 2 R4, CONR4, CH 3 Y', CONR4R4, NH 2 , N(R4) 2 , or N(R4) 3 + Z " , where Y' is halogen, OH, OR4, or a functional group having a molecular weight equal to or less than 100,000 daltons, R4 is a functional group having a molecular weight equal to or less than 100,000 daltons, R5 is a methylene group or an ethylene group, X is H, vinyl, ethyl, acetyl or formyl, Y is methyl or formyl, and Z is a physiologically acceptable charge balancing ion.. 6. A free base or a metal complex having the structure of one of Compound III and Compound IV, below: Compound III Compound IV wherein M is 2H or a metal cation and, associated with the metal cation, a physiologically acceptable charge balancing ion, Rl, R2 and R3 can be the same or different, and each is CO 2 H, CO 2 R4, CONR4, CH 3 Y', CONR4R4, NH 2 , N(R4) 2 , N(R4) 3 + Z\ or CONHR6OR7 where R4 is an alkyl group, R6 is a bivalent moiety composed of a number, n, of alkylene groups and (n minus 1) oxygens, each oxygen linking two alkylene groups through an ether linkage and R7 is an alkylene group, X is H, vinyl, ethyl, acetyl or formyl, and Y is methyl or formyl with the proviso that the molecule includes at least one R6 group, 7. A metal complex as claimed in claim 6 where M is Ag, Al, Ce, Co, Cr, Cu, Dy, Er, Eu, Fe, Ga, Gd. Hf, Ho, In, La, Lu, Mn, Mo, Nd, Pb, Pd, Pr, Pt, Rh, Sb, Sc, Sm, Sn, Tb, Th, Ti, Tl, Tm, U, V, Y, Yb, Zn or Zr. 8. A metal complex as claimed in claim 7 where M Zn, Sn, Pd„ Pt, In 113 , In 115 or a mixture of In" 3 and In" 5 . 9. A phototherapeutic compound as claimed in claim 4 having the structure of one of Compound V and Compound VI, below: Compound V Compound VI wherein M is 2H, In 1 13 , In 1 15 or a mixture of In 1 13 and In 115 and, associated with the In 113 , In" 5 or mixture of In" 3 and In 1 15 , a physiologically acceptable charge balancing ion, Rl and R3 can be the same or different, and each is CO 2 CH 3 , CO 2 H. CO 2 R4 , or an amide. where R4 is an alkyl or a phenyl group, R2 is CO 2 CH 3 . CO 2 H, CO 2 R4 , an amide, CH 2 CO 2 CH , CH 2 CO 2 H, or CH 2 CO 2 R4, where R4 is an alkyl or a phenyl group, R5 is methylene or ethylene, X is H, vinyl, ethyl, acetyl or formyl, and Y is methyl or formyl. 10. A phototherapeutic compound as claimed in claim 4 which has the structure: where Rl- R5 can be the same or different and each is CH 2 CH , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X1 " , C(Y1) 2 C(Y1) 3 , CHO, COCH , CO 2 H, CO 2 R6, CONHR6, CH=CHCHO, CH 2 Y, CH=CHCH 2 OH, CH=CHCH 2 OR6, CH(OH)CH , CH(OR6)CH , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR6R6, CN, OH, OR6, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH,) n SR6, (CH,) n OR6, (CH,) n CO,R6, (CH,) n CONHR6, (CH,) n CON(R6) 2 , CO 2 R6, CONHR6, CONR6R6, SR6, SO 3 H, SO 3 R6, SO 2 NHR6. SO 2 N(R6) 2 , SO 2 N(R6) 3 + Xl " ; M is In" 3 , In" 5 or a mixture of In 113 and In 115 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons; Yl is halogen;. Y is H, halogen, OH, OR6 or is a functional group less than or equal to 100000 daltons; R6 is a functional group less than or equal to 100000 daltons; R7 is H, a physiologically acceptable salt, alkyl ( 1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl; XI is a charge balancing ion; and X is O, 2H, (H, OH), S, (H, OR6) or a ketone protecting group. 11. A phototherapeutic compound as claimed in claim 10 wherein: Rl is CH=CH 2 , CHO, Et, COCH 3 R2 is CO 2 CH 3 ,CO 2 H, or an amide R3 and R4 are H R5 is CH 3 X is O M is In" 3 , In" 5 or a mixture of In 1 13 and In" 5 Z is a halide, acetate or OH. 12. A phototherapeutic compound as claimed in claim 4 which has the structure: where each of R1-R17 is H. halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl. substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, C(X) 2 C(X) 3 (where X is a halogen), NR18R18, CN, OH, OR18, CHO, COCH 3 , (CH,) n OH, (CH 2 ) n SH, CH(OR18)CH 3 , (CH 2 ) n O-alkoxy, (CH,) n SR18, (CH 2 ) n OR18(where n = 1, 2, 3, 4, and R5 is a functional groups less than or equal to 100000 daltons), (CH 2 ) n CO,R18 (where R18 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR18, (CH,) n CON(R18) 2 , CO 2 R18, CONHR18, CONR18R18, SR18 (where R18 is a functional group less than or equal to 100000 daltons). SO 3 X, SO 3 R18, SO 2 NHR18, SO 2 N(R18) 2 , SO N(R18) 3 +X " (where R 18 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); A, B, C and D are; C, N, O + , O, S, Te, P, N + (R19)X " (where R 19 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), or combinations thereof; M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide. acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, a protein or biomolecule or functional group less than or equal to 100000 daltons. 13. A phototherapeutic compound as claimed in claim 4 which has the structure: were each of R1-R24 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, C(X) 2 C(X) 3 (where X is a halogen), NR25R25, CN, OH, OR25, CHO, COCH 3 , (CH,) n OH, (CH 2 ) n SH, CH(OR25)CH 3 , (CH 2 ) n O-alkoxy, (CH,) n SR25, (CH,) n OR25 (where n = 1, 2, 3, 4, and R25 is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO,R25 (where R25 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR25, (CH,) n CON(R25) 2 , CO 2 R25, CONHR25, CONR25R25. SR25 (where R25 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R25, SO 2 NHR25, SO 2 N(R25) 2 , SO 2 N(R25) 3 + X " (where R25 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; A, B, C, D, E, F are; C, N, O + , O, S, Te, P, N + (R25)X " (where R25 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), or combinations thereof; Z is a halide , acetate. OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or a protein or biomolecule or functional group less than or equal to 100000 daltons. 14. A phototherapeutic compound as claimed in claim 4 which has the structure: where each R1-R13 is H, halide, alkyl, vinyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), NR14R14, CN, OH, OR 14, CHO, COCH 3 , (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, CH(OH)CH 3 , CH(OR14)CH 3 (CH,) n SR14, (CH,) n OR14 (where n = 1, 2. 3. 4, and R 14 is a functional groups less than or equal to 100000 daltons), (CH,) n CO,R14 (where R14 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR14, (CH,) n CON(R14) 2 , CO 2 R14, CONHR14, CONR14R14, SR14 (where R14 is a functional group less than or equal to 100000 daltons), SO 3 X, SO 3 R14, SO R14, SO 2 NHR14, SO 2 N(R14) 2 , SO 2 N(R14) 3 + X " (where R14 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, a protein or biomolecule or functional group less than or equal to 100000 daltons. 15. A phototherapeutic compound as claimed in claim 4 which has the structure: where each of R1-R13 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), NR14R14. CN, OH, OR 14, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, CH(OH)CH 3 , CH(OR14)CH 3 (CH 2 ) n SR14, (CH,) n OR14 (where n = 1, 2, 3, 4, and R14 is a functional groups less than or equal to 100000 daltons), (CH,) n CO2R14 (where R14 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl. and n=l, 2, 3, 4), (CH,) n CONHR14, (CH,) n CONH(R14) 2 , CO 2 R14, CONHR14, CONR14R14, SR14 (where R14 is a functional group less than or equal to 100000 daltons), SO 3 H. SO 3 R14, SO 2 NHR14, SO 2 N(R14) 2 , SO 2 N(R14) 3 + X " (where R 14 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. 16. A phototherapeutic compound as claimed in claim 4 which has the structure: where each of Rl and R2 is CO 2 R14 (where R14 is alkyl or aryl), CO 2 H (or a salt therof). SO 2 Ph, CN or combinations thereof; Each of R3, R6, R8, R12 is Me. R5 is CH=CH 2 , or CH(OR14)CH (where R14 is alkyl or aryl) Each of R4, R7, R13, R10 is H R9 and Rl l are CH 2 CH 2 CO 2 R15 (where R15 is alkyl or H or a salt of the carboxylic acid). M is In 1 13 , In 1 15 or a mixture of In 1 13 and In 1 15 . Z is a halide , acetate, or OH. 17. A phototherapeutic compound as claimed in claim 4 which has the structure: : where each of A, B, C, D and E is C, N, N + R (where R is alkyl charged or uncharged) or combinations thereof; M is In 1 13 , In 115 or a mixture of In" 3 and In 1 15 and Z is a halide, acetate, OH. 18. A phototherapeutic compound as claimed in claim 4 which has the structure: where each of Rl through R4 is SO 3 H (or a salt thereof), SO 2 NHR5, CO 2 H (or a salt thereof ), CONHR5, OH, OR5 (wherein R5 is an alcohol or ether containing group), amide, N(CH 3 ) 2 , N(Et) 2 . M is In" 3 , In 1 15 or a mixture of In" 3 and In" 5 Z is a halide, acetate, OH. 19. A phototherapeutic compound as claimed in claim 4 which has the structure: where each of R1-R14 is H, halide, methyl, ethyl, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, C(X) 2 C(X) 3 (where X is a halogen), NR15R15, CN, OH, OR 15, CHO, COCH3, CH(OR15)CH3, (CH,) n OH, (CH,) n SH, (CH 2 ) n O-alkoxy, (CH,) n SR15, (CH,) n OR15 (where n = 1, 2, 3, 4, and R15 is a functional groups less than or equal to 100000 daltons), (CH,) n CO,R15 (where R14 is H, a physiologically acceptable salt, alkyl ( 1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkyne and n=l, 2, 3, 4), (CH,) n CONHR15, (CH,) n CON(R15),, CO2R15, CONHR15, CONR15R15, SR15 (where R15 is a functional groups less than or equal to 100000 daltons and n=l, 2, 3, 4), SO H, SO 3 R15, SO,NHR15, SO,N(R15),, SO 3 N(R15) 3 + X ~ (where R15 is a functional groups less than or equal to 100000 daltons and X is a charge balancing ion); M is In 1 13 , In" 5 or a mixture of In" ' ' and In 1 15 Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or a functional group less than or equal to 100000 daltons. a protein or a biomolecule. 20. A phototherapeutic compound as claimed in claim 4 which has the structure: where each of R1-R8 is ethyl or methyl R9 is CH , SO,NH(CH 2 CH,O) n CH 3 (n=l to 1000), SO,N((CH 2 CH,O) n CH 3 ), (n=l to 1000); SO,NH(CH,) n OH (n=l to 1000), CH3, SO,N((CH,CH,) n OH), (n=l to 1000); SO,NC((N(CH 3 ),) 2 ; SO,NH(CH,) n N(CH 3 ), (n=l to 1000); SO 2 NH(CH 2 ) n SH (n=l to 1000); SO,NHC(CH,CH,OH) 3 ; SO,NHCH 2 CO 2 H (or salts thereof); SO,NH(CH,) n CH(NH 2 )CO,H (or salts therof) (n=l to 5); SO 2 NHCH 2 CO,R10 (R10 is alkyl, aryl); SO,NH(CH 2 ) n CH(NH 2 )CO,R10 (R10 is alkyl, aryl) (n=l to 5) M is In 1 13 , In 1 15 or a mixture of In 1 13 and In 1 15 Z is a halide , acetate, OH. 21. A phototherapeutic compound as claimed in claim 4 which has the structure: where each of R1-R8 is ethyl or methyl. R9 is; CH 2 CO,NH(CH,CH,O) n CH (n = 1 to 1000), CH,CO 2 N((CH,CH 2 O) n CH 3 ), (n=l to 1000); CH,CO,NH(CH,) n OH (n=l to 1000), CH,CO 2 N((CH,CH 2 ) n OH), (n=l to 1000); CH,CO,NC((N(CH 3 ),) 2 ; CH,CO,NH(CH 2 ) n N(CH 3 ), (n=l to 1000); CH 2 CO 2 N(CH,) n SH (n=l to 1000); CH,CO,NHC(CH 2 CH 2 OH) 3 ; CH 2 CO,NHCH,CO 2 H (or salts thereof); CH 2 CO,NH(CH,) n CH(NH 2 )CO,H (or salts thereof) (n=l to 5); CH,CO,NHCH,CO 2 R10 (R10 is alkyl, aryl); CH 2 CO,NH(CH 2 ) n CH(NH,)CO 2 R10 (R10 is alkyl, aryl) (n=l to 5) M is In" 3 , In" 5 or a mixture of In 1 13 and In" 5 . Z is a halide , acetate, OH. 22. A phototherapeutic compound as claimed in claim 4 which has the structure: where each of R1-R14 is H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), NR15R15, CN, OH, OR15, CHO, (CH 2 ) n OH, (CH,) n SH. (CH,) n O-alkoxy, CH(OH)CH 3 , CH(OR15)CH 3 (CH,) n SR15, (CH,) n OR15 (where n = 1, 2, 3, 4, and R15 is a functional groups less than or equal to 100000 daltons), (CH,) n CO,R15 (where R15 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkyne and n=l, 2, 3, 4), (CH,) n CONHR15. (CH,) n CON(R15) 2 , CO 2 R15, CONHR15. CONR15R15, SR15 (where R15 is a functional groups less than or equal to 100000 daltons). SO 3 H, SO 3 R15, SO 2 NHR15, SO 2 N(R15) 2 , SO 2 N(R15) 3 + X " (where R15 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion); A, B, C, D are; C, N, O + , O, S, Te, P or combinations thereof; M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. 23. A phototherapeutic compound as claimed in claim 4 which has the structure: where each of Rl through R14 is H, halide, alkyl, cyclic alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alklynyl, amide, ester, C(X) 2 C(X) 3 (where X is a halogen), NR15R15, CN, OH, OR15, CHO, COCH 3 , (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH,) n SR15, (CH,) n OR15 (where n = 1, 2. 3, 4, and R15 is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO2R15 (where R15 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONHR15, (CH,) n CON(R15),, CO 2 R15, CONHR15, CON(R15),, (where R15 is a functional group less than or equal to 100000 daltons), SRI 5 (where R15 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R15, SO 2 NHR15, SO 2 N(R15) 2 , SO 2 N(R15) 3 + X " (where R15 is a functional groups less than or equal to 100000 daltons and X is a charge balancing ion); M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide, acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl or substituted alkynyl, or a functional group less than or equal to 100000 daltons, protein or biomolecule. 24. A phototherapeutic compound as claimed in claim 4 which has the structure: wherein; Rl is CH=CH 2 , Et, CHO, or COCH 3 R4 is Me R3 is H R2 is CO 2 CH , CO 2 H, CO 2 R7 (R7 is an alkyl, phenyl), or an amide Each of A and B is O or NR5 ( R5 is alkyl). X is O or NR6 (R6 is alkyl, an amino acid, an alcohol containing group, or an ether containing group) M is In ." ,, IInn" I IΛ 5 o „r.. a mi •x ,ture o -fP T I.n 13 ' and A τ I.n '5 Z is a halide , acetate, or OH 25. A phototherapeutic compound as claimed in claim 4 which has the structure: where each of Rl- R6 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R7, CONHR7, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR7 or is a functional group less than or equal to 100000 daltons), CH 2 CO R7, CH 2 CONHR7, CH=CHCH 2 OH. CH=CHCH 2 OR7, CH(OH)CH 3 , CH(OR7)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR7R7, CN, O, S, NHR7, OH, OR7, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH,) n SR7, (CH,) n OR7 (where n = 1, 2, 3, 4, and R7 is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO,R7 (where R7 is H, a physiologically acceptable salt, alkyl ( 1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONR7, CO 2 R7, CONHR7, CONR10R7, SR7 (where R7 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R7, SO 2 NHR7, SO 2 N(R7) 2 , SO 2 N(R7) 3 + X " (where R7 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; X is O, H 2 , (H, OH), (H, OR8) S, or a ketone protecting group; M is In 113 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. 26. A phototherapeutic compound as claimed in claim 4 which has the structure: where each of Rl- R8 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) (where X is a halogen), CHO, COCH,. CO 2 H. CO 2 R9, CONHR9, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR9 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R9, CH 2 CONHR9, CH=CHCH 2 OH, CH=CHCH 2 OR9, CH(OH)CH 3 , CH(OR9)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR9R9, CN, O, S, NHR9, OH, OR9, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH 2 ) n SR9, (CH 2 ) n OR9 (where n = 1, 2, 3, 4, and R9 is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO,R9 (where R9 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH 2 ) n CONHR9, (CH,) n CON(R9) 2 , CO 2 R9, CONHR9, CONR10R9, SR9 (where R9 is a functional group less than or equal to 100000 daltons), SO 3 H, SO R9, SO 2 NHR9, SO 2 N(R9) 2 , SO 2 N(R9) 3 + X " (where R9 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; M is In 1 13 , In 1 15 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, a protein or biomolecule or functional group less than or equal to 100000 daltons. 27. A phototherapeutic compound as claimed in claim 4 which has the structure: wherein; Rl is CH=CH 2 , Et, CHO, or COCH 3 R5 is O or NR9 (where R9 is alkyl) R7 is Me R3 is H R4 and R8 are H, CO 2 CH , CO 2 H (or a salt thereof), CO 2 R10 (R10 is an alkyl or phenyl group), an amide, CH 2 CO 2 CH 3 , CH 2 CO 2 H (or a salt thereof), CO 2 R10 (R10 is an alkyl or a phenyl group), or an amide R2 is CO 2 CH 3 , CO 2 H, CO 2 R10 (RIO is an alkyl or phenyl group), or an amide M is In" 3 , In 1 15 or a mixture of In" 3 and In 1 15 Z is a halide , acetate, or OH. 28. A phototherapeutic compound as claimed in claim 4 which has the structure: where each of Rl- R5 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R6, CONHR6, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR6 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R6, CH 2 CONHR6, CH=CHCH 2 OH, CH=CHCH 2 OR8, CH(OH)CH 3 , CH(OR6)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR6R6, CN, O, S, NHR6, OH, OR6, CHO, (CH,) n OH, (CH,) n SH, (CH,) n O-alkoxy, (CH,) n SR6, (CH 2 ) n OR6 (where n = 1, 2, 3, 4, and R6 is a functional group less than or equal to 100000 daltons), (CH,) n CO-,R6 (where R6 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONR6, CO 2 R6, CONHR6, CONR6R6, SR6 (where R6 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R6, SO 2 NHR6, SO 2 N(R6) 2 , SO 2 N(R6) 3 + X " (where R6 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons: X is O, NR6 (where R6 is H, alkyl (1-10 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, an amino acid, an amino acid ester or a functional group less than or equal to 100000 daltons); A and B are O, NH, NR6 or combinations thereof; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons. 29. A phototherapeutic compound as claimed in claim 4 which has the structure: wherein: Rl is CH=CH 2 , Et. CHO, or COCH 3 R4 is O or NR6 (where R6 is alkyl) R5 is MeR3 is H R2 is CO 2 CH 3 , CO 2 H, CO 2 R7 (R7 is an alkyl or phenyl group), or an amide X is O, NR6 (R6 is alkyl, an amino acid, an alcohol containing group, or an ether containing group) M is In" 3 , In" 5 or a mixture of In 113 and In 115 Z is a halide , acetate, OH, and A and B are O or NR6 where R 6 is alkyl. 30. A phototherapeutic compound as claimed in claim 4 which has the structure: where each of Rl- R6 is CH 2 CH 3 , CH=CH 2 , CH=CHCH 2 N(CH 3 ) 2 , CH=CHCH 2 N + (CH 3 ) 3 X " (where X is a charge balancing ion), C(X) 2 C(X) 3 (where X is a halogen), CHO, COCH 3 , CO 2 H, CO 2 R7, CONHR7, CH=CHCHO, CH 2 Y, (where Y = H, halogen, OH, OR7 or is a functional group less than or equal to 100000 daltons), CH 2 CO 2 R7, CH 2 CONHR7, CH=CHCH 2 OH, CH=CHCH 2 OR7, CH(OH)CH 3 , CH(OR7)CH 3 , H, halide, alkyl, cyclic alkyl (3-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amide, ester, NR7R7, CN, O, S, NHR7, OH, OR7, CHO, (CH,)„OH, (CH,) n SH, (CH,) n O-alkoxy, (CH,) n SR7, (CH 2 ) n OR7 (where n = 1, 2, 3, 4, and R7 is a functional group less than or equal to 100000 daltons), (CH 2 ) n CO,R7 (where R7 is H, a physiologically acceptable salt, alkyl (1-6 carbons), aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, or substituted alkynyl, and n=l, 2, 3, 4), (CH,) n CONR7, CO 2 R7, CONHR7, CONR7R7, SR7 (where R7 is a functional group less than or equal to 100000 daltons), SO 3 H, SO 3 R7, SO 2 NHR7, SO 2 N(R7) 2 , SO 2 N(R7) 3 + X " (where R7 is a functional group less than or equal to 100000 daltons and X is a charge balancing ion), protein or biomolecule or functional group less than or equal to 100000 daltons; X is O, H 2 , (H, OH), (H, OR7). S, or a ketone protecting group; M is In" 3 , In" 5 or a mixture of In" 3 and In" 5 ; Z is a halide , acetate, OH, alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, protein or biomolecule or functional group less than or equal to 100000 daltons.

Inventors: PHADKE AVINASH S, ROBINSON BYRON C, PHADKE, AVINASH, S., ROBINSON, BYRON, C.
Applicants: MIRAVANT PHARM INC, PHADKE AVINASH S, ROBINSON BYRON C, MIRAVANT PHARMACEUTICALS, INC., PHADKE, AVINASH, S., ROBINSON, BYRON, C.
Application year: 1998
Main classification: A61K31
IPC codes: A61K31