METHODS OF PRETREATING HYPERLIPIDEMIC INDIVIDUALS WITH A FLUSH INHIBITING AGENT PRIOR TO THE START OF SINGLE DAILY DOSE NICOTINIC ACID THERAPY TO REDUCE FLUSHING PROVOKED BY NICOTINIC ACID

Abstract: The present invention relates to pretreating individuals with an effective amount of a flush inhibiting agent for a sufficient period of time prior to the start of single daily dose nicotinic acid therapy to reduce the capacity of nicotinic acid to induce flushing reactions in such individuals during nicotinic acid therapy. In accordance with the present invention, the flush inhibiting agents are administered orally one to four times a day, and preferably one to two times per day, for between about 7 to about 14 days prior to the start of the nicotinic acid therapy. Examples of flush inhibiting agents include nonsteroidal anti-inflammatory agents. Aspirin is a prefered flush inhibiting agent and may be orally administered in daily doses of between about 80 mg to about 1000 mg, and preferably between about 80 mg and about 650 mg, and more preferably between about 80 mg and about 325 mg, during the pretreatment period. Also consistent with the present invention, the pretreatment therapy may be continued during and administered concurrently with the nicotinic acid therapy, in which the nicotinic acid is preferably administered once per day as a single dose during the evening hours or before or at bedtime. The nicotinic acid may be administered alone or in combination with HMG-CoA reductase inhibitors as well as other lipid-altering agents, like cholestyramine and colestipol.

Description: METHODS OF PRETREATING HYPERLIPIDEMIC INDIVIDUALS WITH A FLUSH INHIBITING AGENT PRIOR TO THE START OF SINGLE DAILY DOSE NICOTINIC ACID THERAPY TO REDUCE FLUSHING PROVOKED BY NICOTINIC ACTO Field of the Invention The present invention relates to pretreating individuals with an effective amount of a flush inhibiting agent for a sufficient period of time prior to the start of single daily dose nicotinic acid therapy to reduce the capacity of nicotinic a id to induce flushing reactions during such nicotinic acid therapy, and administering to the pretreated individuals nicotinic acid once per day as a single dose during the evening hours or before or at bedtime. Background Hyperiipidemia or an elevation in serum lipids is associated with an increase incidence of cardiovascular disease and atherosclerosis. Specific forms of hyperiipidemia include, for example, hypercholestererraa, familial dysbetaiipoproteinemia, diabetic dysiipidemia, nephrotic dyslipidemia and familial combined hyperiipidemia. Hyperchoiesteremia is characterized by an elevation in serum low density lipoprotein-cholesteroi and serum total cholesterol Low density lipoprotein (LDL- cholesterol) transports cholesterol in the blood. Familial dysbetaiipoproteinemia, also known as Type m hyperiipidemia, is characterized by an accumulation of very low density lipoprotein- cholesteroi (VIJ3L-choiestero particles called beta- VLDLs in the serum. Also associated with this condition, there is a replacement of normal apolipoprotein £3 with abnormal isoform apolipoprotein E2. Diabetic dyslipidemia is characterized by muitipie lipoprotein abnormalities, such as an overproduction of VLDL-cholesteroi, abnormal VLDL trigiyceride lipotysia, reduced LDL- cholesteroi leceptor activity and, on occasion, Type HI hyperiipidemia. Nephrotic dyslipidemia is difficult to treat and frequently includes hyperchoiesteremia and hvpertπgryceridernia. Familial combined hyperiipidemia is characterized by multiple phenotypes of hyperiipidemia, i.e., Type Ha, lib, W, V or h perapobetahpopr einemia. It is well known that the likelihood of cardiovascular disease can be decreased, if the serum lipids, and in particular LDL-choiesterol, can be reduced. It is also well known that the progression of atherosclerosis can be retarded or the regression of atherosclerosis can be induced if serum lipids can be lowered.. In such cases, individuals diagnosed with hyperiipidemia or hyperchoiesteremia should consider lipid-lowering therapy to retard the progression or induce the regression of atherosclerosis for purposes of reducing their risk of cardiovascular disease, and in particular coronary artery disease. Hypertriglyceridemia is also an independent risk factor for cardiovascular disease, such as coronary artery disease. Many people with hyperiipidemia or hyperchoiesteremia also have elevated trigiyceride levels. It is known that a reduction in elevated trigtycerides can result in the secondary lowering of cholesterol These individuals should also consider lipid-lowering therapy to reduce their elevated trigtycerides for purposes of decreasing their incidence of atherosclerosis and coronary artery disease. Cholesterol is transported in the blood by lipoprotein complexes, such as VLDL-cholesteroi, LDL-cholestero and high density lipoprotein-choiesterol (HDL-cholesteroi). LDL carries cholesterol in the blood to the subendothelial spaces of blood vessel wails. It is believed that peroxidation of LDL-cholesterol within the subendothelial space of blood vessel wails leads to atherosclerosis plaque formation. HDL-cholesteroi, on the other hand, is believed to counter plaque formation and delay or prevent the onset of cardiovascular disease and atherosclerotic symptoms. Several subtypes of HDL-cholesteroi, such as HDL,-cholesterol HDL j -cholesterol and HDL,- cholesterol have been identified to date. In the past, there have been numerous methods proposed for reducing elevated cholesterol levels and for increasing HDL-cholesteroi levels. Typically, these methods include diet and/or daily admiriistration of lipid-altering or nypoiipidemic agents. Another method proposed concerns periodic plasma dilapidation by a continuous flow filtration system, as described in U.S. Patent No. 4,895,558. Several type* of hypolipidemic agents have been developed to treat hyperiipidemia or hyperchoiesteremia or noπnoiipidernics diagnosed with cardiovascular disease. In general, these agents act ( 1 ) by reducing the production of die serum lipoproteins or lipida, or (2) by enhancing their removal from die serum or plasma. Drugs d at tower die uiuiaiuaiiou of serum lipoproteins or lipids include inhibitors of HMG-CoA reductase, the rate controlling enzyme in the btosynthetic pathway of cholesterol Examples of HMG-CoA reductase inhibitors include mevastatin, U.S. Patent No. 3,983,140, lovastatin also referred to as mevinolin, U.S. Patent No 4,231,938, pravastatin, U.S. Patent Nos. 4,346,227 and 4,410,629, lactones of pravastatin, U.S. Patent No. 4,448,979, velostatin, also referred to as syπvinolin, simvastatin, U.S. Patent Nos. 4,448,784 and 4,450,171, rivastatin, fluvastatin, atorvastatin and cerivastatia For other examples of HMG-CoA reductase inhibitors, see U.S. Patent Nos. 5,217,992; 5,196,440; 5,189,180; 5, 166,364; 5,157,134; 5,110,940; 5,106,992; 5,099,035; 5,081,136; 5,049,696; 5,049,577; 5,025,017; 5,011,947; 5,010,105; 4,970,221; 4,940,800; 4,866,058; 4,686,237; 4,647,576; European Application Nos. 0142146A2 and 0221025A1; and PCT AppUcation Nos. WO 86703488 and WO 86/07054. Other drugs which lower serum cholesterol include, for example nicotinic acid, bile acid sequestrants, e.g., cholestyramine, coiestipol DEAESephadex (SechoiexΦ and PolidexideΦ), probucoi and related compounds as disclosed in U.S. Patent No. 3,674,836, lipostabil (Rhone- Poulanc), Eisai E5050 (an N-substituted eύunoiamine derivative), imanixil (HOE-402) tetrahydrolipstatin (THL), isitigmastanyiphosphorylcholine (SPC, Roche), anύnocyclodextrin (Tanabe SeiyokuX Ajinomoto AJ-814 (azuiene derivative), meiinamide (SumhomoX Sandoz 58-035, American Cyanimid CL-277,082 and CL-283,546 (disubstituted urea derivativesX ronitol (which has an alcohol which corresponds to nicotinic acid), neomyάn, p-aminosaiicyiic acid, aspirin, quartemary amine poiy(diaUyldimethyiammonium chloride) and ionenes such as disclosed in U.S. Patent No. 4,027,009, poly(dialtylmedιyUunine) derivatives such as disclosed in U.S. Patent No. 4,759,923, omega-3 -fatty acids found in various fish oil supplements, fibric acid derivatives, e.g., gemfibroziL clofibrate, bezafibrate, fenofibrate, ciprofibrate and clinofibrate, and other known serum cholesterol lowering agents such as tiiose described in U. S. Patent No. 5,200,424; European Patent Application No. 006583SA1. European Patent No. 164-698- A, G.B. Patent No. 1,586,152 and G.B. Patent Application No. 2162- 179- A. Nicotinic acid, also known as niacin, has been used for many years in the treatment of hyperiipidemia or hyperchoiesteremia. This compound has long been known to exhibit the beneficial effects of reducing total cholesterol, VLDL-cholesterol and VLDL-cholesteroi remnants, LDL- choiestero trigrycerides and apolipoprotein a, known as "Lp(a)," in the human body, while increasing desirable HDL-cholesteroi Nicotinic acid has normally been administered three times per day after meals. This dosing regimen is known to provide a very beneficial effect on blood lipids as discussed in Knopp et al.; "Contrasting Effects of Unmodified and Time-Release Forms of Niacin on Lipoproteins in Hyperiipidemic Subjects: Clues to Mechanism of Action of Niacin"; Metabolism (34)7:642-647 (1985). The chief advantage of this profile is the ability of nicotinic acid to decrease total cholesterol LDL-cholesterol trigrycerides and Lp(a) while increasing HDL-cholesteroi particles. While such a regimen does produce beneficial effects, cutaneous flushing and die like still often occurs in the hyperϋpidemics to whom the nicotinic acid- is administered. In order to avoid or reduce the cutaneous flushing resulting from nicotinic acid therapy, a number of agents have been suggested for administration with an effective aπtihyperiipidemic amount of nicotinic acid, such as guar gum as reported in U.S. Patent No. 4,965,252, mineral salts as disclosed in U.S. Patent No. 5,023,245, inorganic magnesium salts as reported in U.S. Patent No. 4,911,917, and non-steroidal anti-inflammatories, such as aspirin, as disclosed in PCT Application No. 96/32942. These agents have been reported to avoid or reduce d e cutaneous flushing side effect commonly associated with nicotinic acid dividend dose treatment Another method of avoiding or reducing the side effects associated with immediate release niacin is d e use of extended or sustained release formulations. Extended or sustained release formulations are designed to slowly release the active ingredient from die tablet or capsule, which allows a reduction in dosing frequency as compared to d e typical dosing frequency associated with conventional or πrnnrriiatft dosage forms. The slow drug release reduces and prolongs blood levels of die drug and, dais minήnizeβ or lessens the cutaneous flushing side effects that are associated with conventional or immediate release niacin products. Extended or sustained release formulations of niacin have been developed, such as NicobidΦ capsules (Rhone-Poulenc Rorer), Endur-acin Φ (Innovite CoφorationX and the foπnulations described in U.S. Patent Nos. 5,126,145 a^ which describe a sustained release niacin formulation cc«tammg wo different types of hydroxy propyl methyicelluloses and a hydrophobic component Studies in hyperiipidemic patients have been conducted witii a number of extended or sustained release niacin products. These studies have demonstrated that the extended or sustained release products do not have the same advantageous lipid-ahering effects as immediate release niacin, and in fact have a worse side effect profile compared to the immediate release product. The major disadvantage of the sustained release formulations, as reported in Knopp et al.: etabolism 34(7):642-647 (1985), is the significantly lower reduction in trigrycerides (-2% for the sustained release versus - 38% for the immediate release) and lower increase in HDL-cholesteroi (+8% for d e sustained release versus +22% for the immediate release) and HDLj-cholesterol particles, which are known by the art to be most beneficial (-5% for the sustained release versus +37% for the immediate release). Additionally, extended or sustained release niacin formulations are known to cause greater incidences ofHver toxicity, as described in Henken et aL: Am J Med. 91 1991 (1991) and Daltoαet al.: Am J Mcd. 93: 102 (1992). There is also great concern regarding d e potential of these formulations in disrupting glucose metabolism and uric acid levels. In a previous edition of die Journal of the American Medical Association (JAMA), an article appeared which presented research results investigating the liver toxicity problems associated with a sustained release form of nicotinic acid. "A Comparison of the Efficacy and Toxic Effects of Sustained- vs. Immediate-Release Niacin in Hyperchoiesteroiernic Patients", McKenney et al., JAMA. 271( 9): 672 (March 2, 1994). The article presented a study of twenty-three patients. Of that number, 13 or 78 percent were forced to withdraw because liver function tests (LFTs) increased indicating potential liver damage. The conclusion of d e authors of that article was that the sustained release form of niacin "should be restricted from use." A similar conclusion was reached in an article by representatives of die Food and Drug Administration, and entided "Hepatic Toxicity of Unmodified and Time-Release Preparations of Niacin", Rader et aL: Am I M 92:77 (January, 1992). Because of these studies and similar conclusions drawn by odier health care professionals, the sustained release forms of niacin have experienced limited utilization. HMG-CoA reductase inhibitors have also been used for many years to treat hyperiipidemia. These compounds are known to exhibit beneficial effects of reducing total cholesterol and LDL- cholesterol in die human body, and elevating HDL-cholesteroi levels in some individuals. Grundy SM: F.nyl J Med. 319(l):24-32, at 25-26 and 31 (July 7, 1988). The conversion of HMG-CoA to mevaionate is an early step in the biosynthesis of cholesterol. Inhibition of HMG-CoA reductase, which interferes with the production of mevaionate, is the basis by which the HMG-CoA reductase inhibitors exert their total cholesterol-lowering and LDL-cholesterol-lowering effects. Grundy SM: N Enyl J ed. 319(l):24-32, at 25 and 26 (July 7, 1988). HMG-CoA reductase inhibitors are not without drawback, however. HMG-CoA reductase inhibitors are known to induce hepatotoxicity, myopathy and rhabdomyolysis, as reported in, for example, Garnett WR: Am J Cardiol 78(Suppi 6A):20-25 (Sept 26, 1996); The Lovastatin Pravastatin Study Group: A J CardioL 71:810-815 (April 1, 1993); Dujovne CA et al.: Am J Med, 91(Suppi lB):25S-30S (Juh/ 31, 1991); and ManteU GM e aL: Am J Cardiol 66: 1B-1 SB (Set. 18, 1990). Moreover, on Page 1700, in column 3, of the Physicians' Desk Reference (PDR) 50th Ed., 1996, it reports that lovastatin, an HMG-CoA reductase inhibitor should be used with caution in patients who have a past history of liver disease, and that lovastatin therapy is coπtraindicated for those individuals whh active liver disease or unexplained persistent elevations of serum transaminases. The 1996 PDR further reports on Page 1701, in column 1, that rhabdomyolysis has been associated with lovastatin therapy alone and when combined with lipid-lowering doses (≥ lg/day) of nicotinic acid, and that physicians contemplating combined therapy with lovastatm and lipid-lowering doses of nicotinic acid should carefully weigh d e potential benefits and risks and should carefully monitor individuals for any signs and symptoms of muscle pain, tenderness, or weakness, particularly during d e initial montha of tiierapy and during any periods of upward dosage titration of either drug. The 1996 PDR further reports on page 1701, in column 1, that cases of myopathy have been associated whh patients taking lovastatin concomitantiy with lipid-lowering doses of nicotinic acid. The 1996 PDR also reports similar contraindications (1) for fluvastatin on page 2267, column 3, and on page 2268, column 1, (2) for pravastatin on page 767, column 1, and (3) for siravastatin on page 1777, column 2. Still fiπther, the PDR recommends on page 768, column 3, that concomitant therapy with HMG-CoA reductase inhibitors and these agents [lipid lowering doses of nicotinic acid] is generally not recommended. Notwithstanding the recommendations in the 1996 PDR, Grundy SM: N Engl J Med, 319(l):24-33 (July 7, 1988), reports that HMG-CoA reductase inhibitors when used alone (at pages 29-30) and nicotinic acid when used alone (at page 24) are effective in reducing elevated cholesterol plasma levels. Grundy further reports on page 24, in column 2 at lines 10-25, that "[b]ecause of their efficacy... bile add sequestrants (cholestyramine and colestipol) and niacin are probably die drugs of first choice for hyperchoiesteremia...Akh iugh these drugs can be highly effective and are satisfactory for use in many patients whh high cholesterol levels, they unfortunately are not well tolerated by all patients. Therefore, in spite of their proved usefulness, bile add sequestrants and niacin are not ideal cholesterol-lowering agents." Still further, Grundy reports on page 30, in column 1 at lines 13-17, that d e ".. administration of [HMG-CoA] reductase inhibitors twice a day is somewhat more effective than administration once a day, at d e same total dosage." Grundy also reports on page 29, in column 1 at lines 7-11, "...that the combination of lovastatin and cyciosporine, gemfibrozii or nicotinic add may predispose patients to myopathy and occasionally even to rhabdomyolysis." Still further, Grundy reports on page 30, in column 1 at lines 54-59, that "[d e combination of lovastatin and niacin has not been shown to be safe in a controlled clinical trial; furthermore, a manifestation of an adverse interaction between die agents, such as myopathy, could occur." But see Gardner SF et al.: Pharmacntheπφv. 16<3):421-423 (1996); Pasternak RC et aL: Arm Intern Med. 125(7):529-540 (Oct 1, 1996); O'KeefeJHet aL: Am J Cardiol 76:480-^84 ( Sept I, 1995); and Davignon J et al.: Am i Cardiol 73:339.345 (Feb. 15, 1994). In VacekJLetaL: A JLCjriiQL 76: 182-184 (July, 15, 1995), they report on page 183 that "...because of the present state of knowledge of d e risks of hepatotoxiciry whh slow-release forms of nicotinic acid, this form of the drug should probably not be used [in combination with lovastatin] in future trials or clinical practice." Consistert widi the reports by VacekJL et al and die 1996 PDR, the artide by Jacobson TA and Amorosa LF: Am J Cardiol, 73:25D-29D (May 26, 1994), reports, on pages 28D-29D, that because "[a]bnormalities in liver enzyme profiles and fulminant hepatic failure have also been assoάated wiw the use of niacin, particularly sustained-release preparations... the use of fluvastatin in combination whh a sustained release niacin preparation cannot generally be recommended based upon this study, which only examined crystalline or immediate release niacin." Therefore, it can be seen from the sdentific literature that there is a need for development of Upid-ahering or hypolipidemic pharmaceuticals and methods of delivering said pharmaceuticals which wouid provide patients with "balanced lipid alteration," i.e., reductions in total cholesterol, LDL- cholesterol trigiycerides and Lp(a), as well as increases in HDL parades, whh an acceptable safety profile, especially as to liver toxicity, effects on glucose metabolism, uric add levels, myopatity and rhabdomyolysis. Summary of the Invention In brief, the present invention alleviates and overcomes certain of d e above-identified problems and shortcomings of die present state of HMG-CoA reductase inhibitor therapy and nicotinic add therapy through the discovery of novel HMG-CoA reductase nicotinic add pharmaceutical combinations for oral administration and metiiods of treatment with such pharmaceutical combinations. In accordance witii the present invention, a pharmaceutical combination for oral administration is provided to alter serum lipid levels in individuals, e.g., reducing hyperiipidemia and irihibiting atherosclerosis, without causing drug-induced hepstoxiάry, rhabdomyolysis, or myopathy. Generally speaking, die pharmaceutical combinations of d e present invention comprise nicotinic acid, a derivative of nicotinic acid, a compound which is metabolized by die body to form nicotinic add or any mixturea thereof in an extended rdease form, and an HMG-CoA reductase inhibitor. The pharmacwtfical cπmWnat τr« are sdmmister^ lipids levels such aa total cholesterol, VLDL-cholesteroi LDL-cholesterol, Lp(a) and trigiycerides levels, and to enhance or increase HDL-cholesteroi levels. This is accomplished without causing αrυg-induced her j atotoxkaty, rhabdomyolysis or myopathy or adversely effecting glucose metabolism or uric add levds, or at least without causing such side effects in at least an appreciable number of individuals to such a levd that discontinuation of such therapy would be required. In accordance with the present invention, d e pharmaceutical combinations are administered once a day as a single oral dose. Preferably, and for those individuals on a typical day time schedule, the single oral dose is administered during evening hours, such as with or after their evening meals or at their bedtimes, to achieve in those individuals during d e night effective in vivo levels for reducing total cholesterol VLDL-cholesterol LDL-cholesterol Lp(a) and trigiycerides levels and for enhancing or increasing HDL-cholesteroi levels, some of which lipid components are biosyntiiesized predominantly at night in such individuals. For those individuals with typical night time, as opposed to day time, schedules, e.g., those individuals who work through die night and sleep during the day, it may be preferable to administer die pharmaceutical combinations of die present invention as a single oral dose at or near their day time bedtimes. It also has been found that when a pharmaceutical combination of d e present invention is administered once a day as a single oral dose, die single dose provides additional total cholesterol LDL-cholesterol, and trigryceride reduction effects over that which is obtained using the nicotinic add alone. In fact has been found that die pharmaceutical combinations of die present invention, when administered as a single oral dose, reduces total cholesterol, LDL-cholesterol and trigiycerides levels to a substantially greater extent than when ehher lipid-lowering drug is administered alone as a single oral dose in an equal dosage amount Moreover, it has been found tiiat die pharmaceutical combinations of the present invention, when administered as a single oral dose, increases HDL- cholesteroi levds to a substantially greater extent tiian when the HMG-CoA reductase inhibitor is administered alone aa a single oral dose in an equal dosage amount It is also believed that when the pharmaceutical combinations of the present invention are administered once a day as a single dose, die single oral dose (1) is at least as effective as die combination of an equal or higher daily dosage of nicotinic a d admmistered in divided oral doses and an equal daily oral dosage of HMG-CoA reductase inhibitor administered separate from die divided doses of nicotinic acid, and (2) it has less capadty to provoke hepatotoxicity than the divided dose dierapy. Quite surprisingly, the pharmaceutical combinations of the present invention can be used to effectively treat for instance, hyperiipidemia (e.g., cholesterol-related cardiovascular disease) and atherosclerosis of multiple etiology, and normolipidemics diagnosed witii or predisposed to cardiovascular disease, without causing drug-induced liver damage, rhabdomyolysis or myopathy, or adversely effecting glucose metabolism or uric add levels. While the pharmaceutical combinations of d e present invention contemplate the combination of (a) an HMG-CoA reductase inhibitor, and (b) nicotinic add, as wdl as derivatives of nicotinic add, compounds which the body metabolizes to nicotinic acid and any combinations thereof in an extended release form, the pieferred pharmaceutical combinations in accordance whh die present invention are pharmaceutical combinations for oral administration which are comprised of an HMG-CoA reductase inhibitor in an immediate release form, and nicotinic add in an extended release form. Preferred HMG-CoA reductase inhibitors indude atorvastatin, cervastatin, fluvastatin, lovastatin, pravastatin and simvastatiπ. In carrying out a method of die present invention, the pharmaceutical combinations of die present invention can be administered to humans and otiier animal spedes, such as bovines, canines, felines, porcines, equines, sheep, rabbits, mice, rats, rodents, monkeys, etc. and, as such, may be incorporated into conventional systemic dosage forms, such as tablets, capsules, caplets, granules, beads, etc Other Upid-aitering or hypolipidemic agents as well as agents known to reduce or prevent cutaneous flushing may be induded in the pharmaceutical combinations or administered concomkandy whh the pharmaceutical combinations in appropriate regimens which complement die beneficial effects of die pharmaceutical combinations of d e present invention, so long as such additives do not defeat d e objectives of die present invention. The present invention also contemplates pretreating subjects with a nonsteroidal anti- inflammatory drag (NSAJD) prior to die stait of nicotinfc acid tiierapy to redu∞ add Pretreatment whh low dosages of an NS AID, such as aspirin, when used according to a predosing schedule, cumulativeiy suppresses prostaglandin D 2 (PGD;) production, making administration of nicotinic add more tolerable. In accordance with die present invention, predosing a subject with an NSAJD involves admmistering a low dose NSAJD, such as aspirin, one to four times a day for at least about 7 days, and preferably for at least about 14 days, prior to nicotinic add administration. The doses administered should be carefully adjusted according to age, weight and condition of the patient as well as the route of administration, dosage form and regimen and die desired result. Thus, for oral administration, a satisfactory result may be obtained employing an HMG-CoA reductase inhibitor in dosages as indicated in, for example, the 1996 Physician's Desk Reference or package inserts for those products, such as in an amount within the range of from about O.OSmg to about 160mg, and preferably from about 0.05 to 80mg, and more preferably from about 0.2mg to about 40mg, in combination with nicotinic add in dosages normally employed, as indicated in die 1996 Physician's Desk Reference, for nicotinic add, such as in an amount whhin die range of from about 250mg to about 3000mg, and preferably from about 500mg to about 2500mg, and most preferably from about lOOOmg to about 2000mg, with die HMG-CoA reductase inhibitor and nicotinic add being employed togetiier in the same oral dosage form or in separate oral dosage forms taken at the same or about the same time. The nicotinic add, therefore, may be daily dosed in increments of, for example, 250mg, 500mg, 750mg, lOOOmg, 1500mg, 2000mg, 2500mg and 3000mg. Thus, the oral dosage forms of the present invention may include nicotinic add in dosage amounts of, for example, 250mg, 375mg, 500mg, 750mg and lOOOmg. It should be understood to those versed in this art that die exact dosing for an HMG-CoA reductase inhibitor will depend upon die particular HMG-CoA reductase inhibitor selected. Therefore, and in accordance witii the present invention, die oral dosage forms may include lovastatin, atorvastatin or pravastatin in dosage amounts of, for example, between about lOmg and about 80mg or more, such aa lOmg, 20mg, 40mg or 80mg, simvastatin in dosage amounts of, for example, between about 5mg and about 80mg or more, such as 5mg, lOmg, 20mg, 40mg or 80mg, fluvastatin in dosage amounta of, for example, between about 20mg and 80mg or more, such as 20mg, 40mg or 80mg, and cerivastatin in dosage amounta of, for example, between about 0.05mg and about 0.3mg or more, such as 0.5mg, 0.1 mg, 0.2mg and 0.3mg, to achieve a desired daily dosage. Thus, and in accordance whh the present invention, an oral solid dosage form, such as tablets, may contain die HMG-CoA reductase inhibitor in an amount of from about 0.05mg to about 40mg, and preferably from about 0.1 mg to about 20mg, and nicotinic add in an amount of from about 250mg to about lOOOmg, and preferably from 500mg to about lOOOmg. Examples of oral solid dosage forms in accordance w h the present invention include: nicotinic add atorvastatin, fluvastatin, lovastatin, pravastatin, or simvastatin tablets in dosage strengths of, for instance, 250mg 5mg, 500mg 5mg, 750mg/5mg, 1000mg/5mg, 250mg 7.5mg, 500mg 7.5mg, 750mg/7.5mg, 1000mg 7.5mg, 250mg/10mg > 500mg 10mg, 750mg/10mg, lOOOmg lOmg, 250mg 20mg, 500mg 20mg, 750mg 20mg, 1000mg 20mg tablets, 250mg/40mg, 500mg/40mg, 750mg 40mg, and 1000mg/40mg; and nicotinic add/cerivastatin tablets in dosage strengths of, for instance, 250mg 0.05mg, 5OOmg 0.05mg, 750mg 0.05mg, 1000mg 0.05mg, 250mg 0.1mg, 500mg/0.1mg, 750mg 0.1mg, lOOOmg/O. lmg, 250mg 0.15mg, 500mg/0.15mg, 750mg/0.15mg, i000mg 0.15mg tablets, 250mg 0.2mg, 500mg/0.2mg_ 750mg 0.2mg, 1000mg/0.2mg tablets, 250mg/0.3mg, 500mg 0.3mg, 750mg 0.3mg and 1000mg 0.3mg tablets. It is therefore an object of die present invention to provide a pharmaceutical combination for oral administration comprising (a) an HMG-CoA reductase inhibitor, and (b) nicotinic add, derivatives of nicotinic add, compounds which are metabolized by die body to form nicotinic add and combinations thereof in a sustained release form for altering serum lipids to treat subjects, e.g., subjects diagnosed. whh hyperiipidemia, atherosclerosis and lipidemia in normolipidemics. It is anotiier object of the present invention to provide an oral solid pharmaceutical combination having extended rdease characteristics for die nicotinic acid, a derivative of nicotinic add, a compc«rj)d metabolized to nicc<i^ and having extended or immediate release characteristics for die HMG-CoA reductase inhibitor. It is yet another object of the present invention to provide a metiiod for employing a composition as above, for treating hyperiip iemics or noπnoiipidemics diagnosed whh or predisposed to cardiovascular disease, which results in little or no liver damage, myopathy or rhabdomyolysis. At least one or more of the foregoing objects, together with the advantages tiiereof over the known art relating to die treatment of hyperiipidemia, which shall become apparent from the specification which follows, are accomplished by the invention as hereinafter described and claimed. In general the present invention provides an improved iipid-altering or antihyperlipidemia pharmaceutical combination of the oral type employing an effective lipid-altering or antihyperiipidemic amount of an HMG-CoA reductase inhibitor and nicotinic add, wherein the pharmaceutical combination comprises compounding de nicotinic add with, for example, from about 5% to about 50% parts by weight of hydroxy propyl methyl cellulose per hundred parts by weight of the tablet or formulation and coating die tablet whh an HMG-CoA reductase inhibitor from about 0.01% to about 30% parts by weight of the tablet or formula. The present invention also provides an orally administered lipid altering or antihyperϋpidemia composition which comprises from about 0.01% to about 30% parts by wdght of an HMG-CoA reductase inhibitor; from about 30% to about 90% parts by wdght of nicotinic add; and, from about 5% to about 50% parts by wdght of hydroxy propyl medryi cellulose. The present invention also indudes a metiiod of altering lipid lev s in subjects, such as treating hyperiipidemia in a hyperiipidemic or lipidemia in a normolipidemic diagnosed with or predisposed to cardiovascular disease. The method comprises die steps of forming a composition which comprises effective lipid-altering amounts of an HMG-CoA reductase inhibitor and nicotinic acid, and an amount of exdpients to provide immediate or extended release of die HMG-CoA reductase inhibitor and extended rdease of die nicotinic add. The method also indudes die step of orally administering the composition to the hyperiipidemic or normolipidemic nocturnalry. A method of treating hyperiipidemia in a hyperiipidemic or lipidemia in a normolipidemic according to die present ύrventkm, comprises dosing die hyperiipidemic or normolipidemic witii an effective lipid-aitering amount of an HMG-CoA reductase inhibitor and nicotinic acid, a derivative of nicotinic acid, a compound metabolized to nicotinic acid by d e body or mixtures thereof. The dose is given once per day, preferably in the evening or at night, combined with a pharmaceutically acceptable carrier to produce a significant reduction in total cholesterol and LDL-cholesterol as well as a significant reduction in trigiycerides and Lp(a), with a significant increase in HDL cholesterol. The above features and advantages of die present invention will be better understood with the reference to die following detailed description and examples. It should also be understood that the particular mediods and formulations illustrating the present invention are exemplary only and not to be regarded as limitations of the present invention. Detailed Description. By way of illustrating and providing a more complete appreciation of the present invention and many of the attendant advantages thereof, die following detailed description and examples are given concerning the novd mediods and pharmaceuticals. The present invention employs an HMG-CoA reductase inhibitor and nicotinic add, a derivative of racotinic add or a compound other than nicotinic add hself which the body metabolizes into, nicotinic add and mixtures thereof thus producing die same effect as described herein. The nicotinic add derivatives and other compounds specifically include, but are not limited to die following: racotinyi alcohol tartrate, d-ghiάtoi hexam∞tinate, aluminum nicotinate, niceritroi, d,l- aipha-tocopheryi nicotinate, 6-OH-nicotinic add, mcotinaria add, mcotinam.de, dcotinamide-N- oxide, 6-OH-m∞tinamide, NAD, N-metiιyi-2-pyπidme-8-<»rboxamide, N-mediyl-mcotinamide, N- ribosyl-2-pyridone-5-carboxide, N-methyi-4-pyridone-5-carboxamide, bradilian, son inicate, hexanicite, roratoi, and esters of nicotinic add such as lower alcohol esters like methyl ethyl, propyl or butyl esters. Each an any such derivative or compound will be collectively referred to hereinabove by "nicotinic add compound." The specific HMG-CoA reductase inhibitors include, but are not limited to, lovastatin and related compounds as disclosed in U.S. Patent No. 4,231,938, pravastatin and related compounds as reported in U.S. Patent Not. 4,346,227 and 4,448,979, mevastatin and related compounds as disclosed in U.S. Patent No. 3,983,140, vdostatin and sύπvastatin and related compounds as discussed in U.S. Patent Nos. 4,448,784 and 4,450,171, fluvastatin, atorvastatin, rivastatin and fluindostatin (Sandoz XU-62-320X with fluvastatin, lovastatin, pravastatin, atorvastatin, sύnvastatm and cerivastatm being preferred. Other HMG-CoA reductive inhibitors which may be employed herein include, but are not limited to, pyrazole analogs of mevalonoiactone derivatives as disclosed in U.S. Patent Nα 4,613,610, indent analogs of mevalonoiactone derivatives as disclosed in PCT application WO 86/03488, 6-[2-(substituted-pyrrol-l-yl)alkyl]pyran-2-ones and derivatives thereof as disclosed in U.S. Patent No. 4,647,576, Searie's SC-45355 (a 3-substituted pentanedioic add derivative) dichloracetate, imidazoie analogs of mevalonoiactone as disdosed in PCT application WO 86707054, 3-carboxy-2-hydroxy-propane-phosphoric add derivatives as disclosed in French Patent No. 2,596,393, 2,3-di-substituted pyrrole, furan and tiiiophene derivatives as disclosed in European Patent Application No. 0221025 A14, naphthyi analogs of mevalonoiactone as disclosed in U.S. Patent No. 4,686,237, octahydro-naphthelenes such as disdosed in U.S. Patent No. 4,499,289, keto analogs of lovastatin as disclosed in European Patent Application No. 0142146 A2, as well as otiier known HMG-CoA reductase inhibitors, such as those disclosed in GB Patent Nos. 2,205,837 and 2,205,838; and in U.S. Patent Nos. 5,217,992; 5,196,440; 5,189,180; 5,166,364; 5,157,134; 5,110,940; 5,106,992; 5,099,035; 5,081,136; 5,049,696; 5,049,577; 5,025,017; 5,011,947; 5,010,105; 4,970,221; 4,940,800; 4,866,058; 4,686,237. As stated hereinabove, HMG-CoA reductase inhibitors and nicotinic add have been employed in die past for die treatment of hyperiipidemia, which condition is characterized by die presence of excess fats such as cholesterol and trigrycerides, in die blood stream. According to one aspect of the present invention, an extended or sustained release composition of nicotinic add coated with an immediate release coating of an HMG-CoA reductase inhibitor is prepared as an example. By "extended rdease" or "sustained release" it is understood to mean a composition which when orally administered to a patient to be treated, die active ingredient like an HMG-CoA reductase inhibitor, nicotinic add, a nicotinic acid compound or mixtures tiiereof will be released for absorption into die blood stream over a period of time. For example, it is preferred diet in a dosage of about 1500 milligrams foaeM i "mgs") of nicotinic add, approximately 100 percent of die nicotinic acid will be released to the blood stream in about 4 to about 8 hours and preferably within about 6 hours following ingestion. While d e nicotinic acid is released from the pharmaceutical combination in a sustained release manner, the HMG-CoA reductase inhibitors can be formulated for immediate or extended release following ingestion. By "immediate rdease,' 1 it is understood to mean that the HMG-CoA reductase inhibhor, which when orally administered to a patient to be treated, will be completely rdeased from the composition for absorption into me blood stream witiiin about 30 minutes following ingestion. A specific sustained release composition according to die present invention employs an effective lipid-altering amount of nicotinic add coated with an effective lipid-altering amount of an HMG-CoA reductase inhibitor. By "effective lipid-altering amount" or "effective antihyperiipidemic amount" it is understood to mean an amount which when orally administered to a patient to be treated, will have a beneficial effect upon die physiology of the patient to include at least some lowering of, one or more of the following, total cholesterol LDL-cholesterol trigiycerides and Lp(a) and at least some increase in HDL-cholesteroi and more particularly an increase in, e.g., HDL-cholesteroi and/or HDL, -cholesterol in the patient's blood stream. The beneficial effect will also include some decreases in the total cholesterol to HDL-cholesteroi ratio and in die LDL-cholesterol- HDL-cholesteroi ratio in the patient's blood stream. In some individuals, die beneficial effect may also include reduction in apolipoprotein B, reduction in apolipoprotein E and/or an increase; in apolipoprotein A-L An exemplary effective lipid-altering amount of nicotinic acid would be from about 250mg to about 3000mg of nicotinic add to be administered according to die present invention, as will be more fully describe hereinbdσw. An exemplary effective lipid-altering amount of an HMG- CoA reductase inhibitor would be from about 0. lmg to about 80 mg. These amounts will of course vary, dependent upon a number of variables, including die psychological needs of die patient to be treated. Preferably, there is also included in a sustained rdease composition according to die present invention, a swelling or sustained rdease agent which is compounded whh die nicotinic add, and/or nicotinic add compounds, such that when the composition is orally administered to die patient the swelling agent will sw l over time in die patient's gastrointestinal tract, and rdease die active nicotinic acid, and/or nicotinic add compound over a period of time. As is known in the art, such swelling agents and amounts thereof may be presdected in order to control die time rdease of die active nicotinic add ingredient Such swelling agents include, but sre not limited to, polymers such as sodium carboxymethyiceUulose and ethylcellulose snd waxea such as bees wax and natural materials such ss gums snd gdatins or mixtures of arty of die above. Because the amount of die sweiling agent will vary depending upon the nature of the agent the time release needs of the patient and the like, it is preferred to employ amounts of the agent which will accomplish the objects of the invention. An exemplary and preferred swelling agent is hydroxy propyl metiiyl cellulose, in an amount ranging from about 5% to about 50% parts by wdght per 100 parts by wdght of tablet or formulation. A preferred example will ensure a sustained time release over a period of approximately 4-8 hours. A binder may also be employed in the present compositions. While any known binding material is useful in the present invention, it is preferred to employ a material such as one or more of a group of polymers having the repeating unit of l-edιenyl-2-pyrrolidinone. These polyvinyi pyπoiidinone polymers generally have molecular weights of between about 10,000 and 700,000, and are also known as "povidone or PVP." Amounts of die binder material will of course, vary depending upon d e nature of die binder and die amount of other ingredients of die composition. An exemplary amount of povidone in the present compositions would be from about 1% to about 5% by wdght of povidone per 100 parts by wdght of die total formulation. Processing aids such as lubricants, including stearic add, magnesium stearate, glyceryl behenate, talc and colloidal silicon dioxide, may also be employed, as is known in the art. An exemplary amount of a lubricant, such as stearic add, in the present compositions would be from about 0.5% to about 2.0% by wdght per 100 parts by wdght of tablet or formulation. Also in accordance with the present invention, die sustained rdease compositions containing the nicotinic acid and or nicotinic add compounds are preferably coated whh an HMG-CoA reductase inhibitor for immediate rdease following oral administration. An exemplary coating in accordance with the present invention comprises an HMG-CoA reductase inhibitor, a plasticizer, film forming and or coating agent and a coloring agent Specific examplea of plastidzers include, but are not limited to, benzyl benzoate, chiorobutanol, dibutyl sebacate, diedryi phthalate, glycerin, mineral oil and lanolin alcohols, petrolatum and lanolin alcohols, potyetiryiene glycol, propylene glycol, sorbitol triacetin and triethyi citrate. An exemplary amount of a plasticizer utilized in die coatings of the present invention would be from about 0.01% to about 5% by wdght of the tablet Specific examples of film forming and or coating agents include, but are not limited to, carboxymethylcellulose sodium, carnauba wax, cellulose acetate phthalate, cetyl alcohol confectioner's sugar, ethylcellulose, gelatin, hydroxyethyi cellulose, hydroxy propyl cellulose, hydroxy propyl methyl cellulose, liquid glucose, maltodextrin, methyl cellulose, microcrystalline wax, poiymethacryiates, potyviπyi alcohol shellac, sucrose, talc, titanium dioxide and zein. An exemplary amount of a film forming coating agent in die present coatings would be from about 0.01% to about 5% by wdght of the tablet Generally speaking to prepare a coating in accordance whh die present invention, an HMG-CoA reductase inhibitor is suspended or dissolved in an aqueous-solution of polyethlene glycol and hydroxy propyl methyl cellulose and tiien sprayed on die sustained release tablets by a n^n-coating process to a thickness containing an effective antihypβriipidemic amount of an HMG-CoA reductase inhibitor. Examples of suitable coating thicknesses in accordance with die present invention are from about 0.1mm to about 2.0mm or more. Coated sustained rdease tablets of various sizes can be prepared, e.g., of about 265mg to I650mg in total wdght containing both of die active substances in the ranges described above, with the remainder being a physiologically acceptable carrier of other materials according to accepted pharmaceutical practice. These coated tablets can, of course, be scored to provide for fractional doses. Gelatin capsules can be similarly formulated. Consistent with die present invention, such dosage forms should be administered to individuals on a regimen of one dose per day, preferably during die evening hours. In order to more finery regulate die dosage schedule, die active substances may be administered separately in individual dosage units at die same time or carefully coordinated times. Since blood levels sre built up and maintained by a regulated schedule of administration, die same resuh is achieved by die shrsihaneous presence of die two substances. The respective substances can be mdividualry formulated in separate unit dosage forms in a manner similar to that described above. Combinations of an HMG-CoA reductase inhibitor and d∞tirac acid and/or nicotinic add compounds in die same pharmaceutical are more convenient and are tiierefore preferred, especially in me coated tablet or capiet form for oral adrninistration. Alternatively, however, die pharmaceutical combinations of die present invention may comprise two distinct oral dosage forms which may be administered concomitantiy, where one oral dosage form is formulated for extended or sustained release of nicotinic add or a nicotinic add compound or mixtures thereof and die other oral dosage form is formulated for extended or immediate release of an HMG-CoA reductase inhibitor. Optionally, die oral pharmaceutical combinations of the present invention may include other active ingredients. In addition, die present invention contemplates that other active ingredients may be administered concurrently with the pharmaceutical combinations of die present invention. Examples of otiier active ingredients include anti-lipidemic agents and flush-inhibiting agents. Specific examples of anti-lipidemic agents include but are not limited to, bile add sequestrants, e.g., cholestyramine, colestipol DEAESephadex (SechoiexΦ and Polidex_deΦ), probucol and related compounds as disdosed in U.S. Patent No. 3,674,836, lipostabil (Rhone-PoulancX Eisai E5050 (an N-substituted etiianolamine derivative), imanbdi (HOE-402) tetrahydroϋpstatin (THL), iatigmastanyiphosphoryichoiine (SPC, Roche), aminocyclodextrin (Tanabe SeiyokuX Ajinomoto AJ- 814 (azuiene derivativeX meiinamide (Sumitomo), Sandoz 58-035, American Cyanimid CL-277,082 and CL-283,546 (disubstituted urea derivativesX neomydn, p-aminosalicylic add, aspirin, quarternary amine poiy(dia yidimediylammonium chloride) and ionenes such as disdosed in U.S. Patent No. 4,027,009, poly(diallyimetiτyianune) derivatives such as disdosed in U.S. Patent No. 4,759,923, omega-3 -fatty adds found in various fish oil supplements, fibric add derivatives, e.g., gemfibroπl clofibrate, bezafibrate, fenofibrate, dprofibrate and ciinofibrate, and odier known serum cholesterol lowering agents such as those described in U.S. Patent No. 5,200,424; European Patent Application No. 0065835A1, European Patent No. 164-698- A, GB. Patent No. 1,586,152 and G.B. Patent Application No. 2162-179-A. Specific BTimplra of ftisbπnhibiting agents indude, but are not limited to, nonsteroidal and- mflammatory drugs such aa aspirin and saacyiate salts; propionic acids such as ibuprofen, flurbiprofen, fenoprofen, ketoprofen, naproxen, sodium naproxen, carprofen and suprofien; indoleacetic add derivatives such as indomethadn, etodolac and sulindac; benzeneacetic acids such as aclofenac, diclofenac and fendofenac; pyrroleacetic adds such as zomepirac and tolrnectin; pyrazoles such as phenyibutazone and oxyphenbutazone; oxicams such as piroxicam; and andiranilic adds such as meclofenamate and mefenamic add. In formulating die compositions, the active substances, in the amounts described above, are compounded according to accepted pharmaceutical practice whh a physiologically acceptable vehicle, carrier, ex pient binder, preservative, stabilizer, flavor, etc., in the particular type of unit dosage form. Additional illustrations of adjuvants which may be incorporated in the tablets are the following: a binder such as gum tragacanth, acacia, com starch, potato starch, alginic add or die like; a sweetening agent such as sucrose, aspartase, lactose or saccharin; a flavoring such as orange, peppermint oil of wintergreen or cherry. When the dosage unh form is a capsule, it may contain in addition to materials of the above type a liquid carrier such as a fatty oiL Various other materials may be present as coatings or to otherwise modify die physical form of the dosage unit For instance, tablets or capsules may be coated with shellac, sugar or bout Some of die active agents described above form commonly known pharmaceutically acceptable salts, such as alkali metal and otiier common basic salts or add addition salts, etc. References to the base agents are therefore intended to include tiiose common salts known to be substantially equivalent to die parent compound. In carrying out the objective of die present invention, die nicotinic add, nicotinic add compounds and/or HMG-CoA reductase inhibitors may be forrnuiated into sustained rdease granules, sustained release partides, sustained release coated parades or sustained rdease beads or pellets according to any metiiod known to the art for the manufacture of pharmaceutical compositions for incorporation into a variety of oral dosage forms suitable for oral use, such as tablets, such as rapidly disintegrating tablets, cornpression coated tablets, enteric coated tablets, capsules, caplets, sachets for sprinkle admmistration, and die like. In addition, the HMG-CoA inhibitors may be formulated into iiiuiiediate release granules or immediate rdease coated raw materials for incorporation into the oral dosage forms of the present invention. A preferred nicotinic sdd sustained release dosage form is die Niaspan* tablets. The Niaspan* tablets can be modified consistent with die present invention to include an HMG-Co reductase inhibitor during die formation of me Niaspan* granules or during die manufacture of the Niaspan* tablet blend prior to compression into the Niaspan* tablets to formulate a pharmaceutical combination of the present invention in which the nicotinic add and HMG-CoA reductase inhibitor are in a sustained release form. Alternatively, the Niaspan* tablets may be coated whh a coating containing an HMG-CoA reductase inhibitor in immediate release form to formulate a pharmaceutical combination of the present invention in which the nicotinic add is in an extended release form and the HMG-CoA reductase inhibitor is in an immediate rdease form. The present invention also contemplates other combined dosage forms containing an HMG- CoA reductase inhibitor and nicotinic add, a nicotinic add compound or mixtures thereof For instance, such combined dosage forms include bilayer or multilayer tablets, capsules or sachets containing, for example, immediate or sustained release granules of an HMG-CoA reductase inhibitor and sustained rdease granules of nicotinic add, a nicotinic add compound or mixtures thereof Bilayer or multilayer tablets may be manufactured utilizing techniques w l known in tins art, such as by lightly prestamping a nicotinic add layer containing sustained release nicotinic add granules, adding a layer containing an HMG-CoA reductase inhibitor either defident in or containing a sustained release or swelling agent and compressing the combined powder to form the bilayer tablet. Optionally, the HMG-CoA reductase layer may further contain ether agents, such as a flush inhibiting agent like as aspirin. In a further embodiment die pharmaceutical combination of die present invention may be enterically coated to dday disintegration and absorption in the gastrointestinal tract For example, (1) sustained r ease nicotinic acid granules or immediate or sustained rdease HMG-CoA reductase inhibitor granules may be individually enterically coated and compressed to form a tablet or a layer of a bilayer tablet or (2) the tablet itsdf or a layer thereof may be coated with an enteric coating. Enterically coated dosage forms do not necessarily dissolve or become absorbed by humans until they pass through the low pH environment of the stomach and pass into die relatively higher pH of the small intestine. Typical materials conventionally used aa enteric coatings include, but are not limited to, cellulose acetate phthalate, potyvinylacetate phthalate, hydroxypropyl medrylcellulose phthalate and methacryiic add-methyi methacryiate copolymers. Such materials can be used individuaily or in combination. Additional formulating agents, such as plastidzers (e.g., one or more pohed t ylene gtycois or propylene giycol) may be added to ensure physical strengtii and processability, e.g., to prevent cracking due to stress, low humidity or otiier factors. Enterically coated nicotinic add or HMG-CoA reductase inhibitors granules can be prepared in a fluid bed granuiator by coating or agglomerating niacin powder with one or more enteric coating materials, such that microspheres or small particles of enterically coated nicotinic add are formed. Alternatively, a whole tablet or capsule comprising an HMG-CoA reductase inhibitor and/or nicotinic add can be coated with enteric coating materials. Typically, the enteric coating process comprises coating die dosage form whh a plurality of layers, e.g., one or two layers or more, of enteric coating material like a methacryiate polymer such as EUDRAGΓT S-100, available from Rohm, preferably by dipping die wdght tablet or capsule into a freshly prepared solution of die material for five seconds. The solution of enteric coating materials) may be prepared by dissolving an appropriate amount of material in, e.g., 100 ml of a 4:6 mixture of acetone and isopropyi alcohol. After each immersion, die coating is allowed to dry in air, e.g., for 30 minutes, prior to the next five-second immersion. A single coating is usually adequate to prevent the capsule or table from dissolving in the stomach. Alternatively, die granules, tablets or capsules may be coated or spray-dried in standard coating machines such as tiiose typically employed in the pharmaceutical industry. The present invention also contemplates methods for pretreating subjects, prior to die start of nicotinic add or nicotinic add combination tiierapy, with a nonsteroidal anti-inflammatory drug (NSAID) in an amount effective to inhibit or reduce prostaglandin PGD j synthesis, so that any flush reaction induced by die nicotinic add tiierapy is lessened or prevented. In carrying out this aspect of the present invention, die pretreatment should start at least about 7 days prior to administration of the nicotinic acid, and preferably for at least about 14 days. While pretreatment for a shorter duration may not provide a subject whh adequate protection against flushing, some protective effect may be observed and, thus, such shorter pretreatment periods may be practiced whhin the scope of the present invention. During pretreatment ofsubjects with an NSAID, the NSAID selected is orally aclministered in at least one to four or more doses daily. However, while three or fewer doses per day is preferred, one or two doses per day are preferential for the convenience and improved compliance of the subjects. The NSAID may be administered orally as an immediate or extended release dosage form. Of course, if an extended rdease dosage form is selected, the NSAID can be administered fewer times daily then a comparable immediate release dosage form, while providing similar protection against nicotinic add-induced flushing. While it is preferable to take an NSAID during pretreatment the present invention also contemplates continued administration of the NSAJD during die nicotimc add or nicotinic add compound treatment This can be accomplished by taking the NSAID as a separate dosage form on a daily basis, or by taking a pharmaceutical component of die present invention which includes an NSATD. Particularly preferred NSAIDs include indomethadn, ibuprofen, naproxen, aspirin, ketoprofen, flurbiprofen, phenyibutazone, and piroxicam. These NSAIDs may be administered in their usual doses for treatment of inflammation. Aspirin is especially preferred. Aspirin may be administered in daily dosages of at least between about 60mg and about lOOOmg, and more preferably at least between about 80mg and 650mg, and most preferably between about 80mg and 325mg. Even though higher daily dosages of aspirin may be consumed to suppress flushing in accordance whh die present invention, diere is risk that these higher dosages, as well as the high end of die preferred dosages, could induce gastrointestinal upset and ulceration. While extended rdease forms are commercially available for some NSAIDs, other extended release formulations may be prepared by conventional methods from tiiose versed in die art, or by blending the NSAID whh the nicotinic add during granules or during die powder blending stage pursuant to die methods described herein to generate a pharmaceutical combination comprised of nicotinic acid and an NSAID in extended rdease form. Alternatively, the NSAJD could be blended w h an HMG-CoA reductase inhibitorin a costing fee immediate release of die NSATD. As a further alternative contemplated by die present invention, extended rdease racoti c acid tablets, such as NiaspanΦ, can be enterically coated for delayed release, which then may be coated with a coat comprised of an HMG-CoA reductase and an NSAID for immediate release. In a further aspect of the present invention, die solid pharmaceutical combinations for oral administration may be formulated into various shapes. For example, tablets may be round flat round/convex, oval flat oval convex, or capsule (caplet) in shape, whereas capsules may be round or elongated in shape. It is presently believed that when tablets are coated in accordance with die present invention, die coatings can be improved if the tablets are in an oval convex shape. For instance, it is believed that by formulating die sustained rdease nicotinic add tablets, such as Niaspan* tablets, into oval/convex shapes, the coatings containing an HMG-CoA reductase inhibitor are improved, as compared to similar coatings on tablets having, for example, a capsule (caplet) shape. The fornaiiations as described above will be administered for a prolonged period, that is, for as long as die potential for devated serum cholesterol and atherosderosis remains or the symptoms continue. Adosing period of at least about 4 weeks maybe required to achieve a desired tiierapeutic benefit. The disclosures of the U.S. patents and patent applications mentioned and cited herein are incorporated herein by reference in their entireties. Examples of various eπibodiments of the present invention will now be further illustrated whh reference to the following examples. Eτ»mpl<> I In order to demonstrate die effectiveness of die compositions and method of die present invention over known antihyperHpidemia compositions and mediods heretofore known in the art, a according to die disdosure heremabove. The composition ingredients and amounts are listed in TABLE IA hereinbdow. TABLE IA Test Tablet Composition Ingredient 37Smg 5ϋθjn 750mg; Nicotinic Add. 375.0 500.0 750.0 Hydroxy propyl 188.7 203.0 204.7 methyi cellulose Povidone 12.9 17.2 25.9 Stearic Add 5.8 7.3 9.9 TOTAL 582.4mg 727.5mg 990.5mg The ingredients were compounded together to form a tablet More specifically, NiaspanΦ once-daily tablets in accordance whh die present invention utilize a hydrophilic matrix controlled drug delivery system. This is a dynamic system composed of polymer wetting, polymer hydration and polymer disintegration dissolution. The mechanism by which drug rdease is controlled depends on, for example, initial polymer wetting, expansion of die gd layer, tablet erosion and niacin solubility. After mrtial wetting, die hydrophilic poiymer starts to partially hydrate, forming a gd layer. As water permeates into the tablet increasing the tiiickness of the gd layer, drug diffuses out of die gd layer. As die outer layer of the tablet becomes fully hydrated h erodes. It is believed tiiat tins erosion results in additional drug rdease. The controlled rdease from this matrix delivery system can be modified depending on die type and molecular wdght of hydrophilic poiymer used. A NiaspanΦ formulation consists of Niacin, MetiiocdΦ E10M Premium, Povidone K90 and Hystrene 5016 (stearic add). MethocdΦ E10M Premium is utilized as a controlled-rdease agent in die NiaspanΦ formulation. Metiiocd is a partly O-mctiryiated snd O-(2-hydroxypτopyiated) cellulose and is available in several grades which vary in terms of viscosity snd degree of substitution. Methocd is manufactured by Dow Chemical Povidone K90 is employed as a granulating/binding agent in a NiaspanΦ formulation. Povidone is a synthetic poiymer consisting of linear l-viπyi-2-pyrrolidone groups, die degree of polymerization of which results in polymers of various molecular weights, or aa indicated above. It is characterized by hs viscosity in aqueous solution, relative to that of water, expressed as a K-value, ranging from 10-120. Povidone K90 has an approximate molecular weight of 1,000,000. Povidone is a hygroscopic, water soluble material. Povidone K90 present in a NiaspanΦ formulation is manufactured by ISP (International Speciality Products). Hystene 5016 is utilized as an external lubricant in the NiaspanΦ formulation. Hystrene 5016 is a mixture of stearic add and palmitric add. The content of stearic add is not less than about 40.0% and die sum of the two adds is not less than about 90.0%. Hystrene 5016 is manufactured by Witco. Refer to Table IB for NiaspanΦ formulation details. Qualitatively, die four tablet strength formulations are identical The major component of each formulation is a granulated mixture of Niacin, Methocd ElOM and Povidone K90. The granulation process improves compression properties. TABLE IB NiaspanΦ Tablet Formulations NiaspanΦ formulations are presented in white caplet shape tablets. Caplet dimensions differ with respect to product strength. The 375mg and 500mg NiaspanΦ tablets are compressed whh tooling measuring approximately 0.687" in length x. 0.281" by widtit The length and widtii of the 750mg and lOOOmg tooling measures approximately 0.750" x. 0.320". Target tablet wdght and hardness dictate drickncss across the four NiaspanΦ products. The production of die NiaspanΦ tablets will now be described generally as set forth bdow. NiaspanΦ Granulation Process Flo chart flaw M«t»ri»ι» Proceaa Flow Equipment Niacin Granulate High shear granulator Povidone K90 (Litdeford FM130) Methocd ElOM (Intragranuiar) Purified Water 1 Dry Fluid bed drier (Giatt fluid bed drier) 1 Pared size reduction Mill (Kemutec Betagrind) Niaapan-tt Granulation Proceaa Description NiaspanΦ granulation raw materials are dispensed and granulated in a high shear granulator. The wet granules are sieved into a fluid bed drier and are dried. When the drying process is complete, the granules are milled. Milling ensures uniform particle size distribution throughout the NiaspanΦ granulation. ttiπpinft τ * bi t Prnf — Ψlmr H"-» Ra M? te " al * Proςgsa Flow Equipment NiaspanΦ Tablet Blend Methocd ElOM Blend Milled NiaspanΦ granules with Blender (Extragranular) extragranular Methocd ElOM and (Patterson- elley Hystrene 5016 Hystrene 5016 V-BIender) (Stearic Add) I Niaspanft Tahlet Manufacture Compress NiaspanΦ Tablet Blend Rotary tablet press Niaapanig Tablet Proceaa Description A KiaspanΦ tablet blend manuf mired by bl extragranular Methocd ElOM and Hystrene 5016. The quantities of each NiaspanΦ tablet blend component will depend on die particular NiaspanΦ dose being manufactured (refer to Table IB). A NiaspanΦ tablet blend is compressed to form NiaspanΦ tablets. NiaspanΦ tablet physical properties will vary depending on die particular NiaspanΦ dose being manufactured. Production of NiaspanΦ tablets will now be discussed in greater detail The initial stage of manufacturing is the same for all four tablet strengths ofNiaspanΦ (375, 500, 750, and lOOmg). One batch of KiaspanΦ granulation is comprised of four individual 40.0kg units of granulation which are processed separately, but under like conditions. The four individual granulations are sampled and tested individually and subsequently rdeased for blending. The base grarαilation is not strength specific and may be used to manufacture any tablet strength ofNiaspanΦ. The ingredients in the base granulation are set forth in Table IC bdow: TABLE IC •Purified Water, USP is used as a granulation reagent and does not appear in the finished granulation. Raw materials are quaπtativery dispensed into appropriately labded double potyetiiylene-lined containers using calibrated scales. Purified Water, USP is dispensed into an appropriate vessd from which it is later pumped during die wet-massing operation. A Littleford FM130 granulator is charged whh approximately one half of die Niacin, USP required for die process unit (- 17.4kg) followed by about 4.00kg of Methocd, USP ElOM Premium CR Grade; about 1.20kg of Povidone, USP; and the balance of die Niacin, SP (- 17.40kg). The powder bed is dry mixed in die Litdeford FM130 granulator, with choppers on, for approximately 1 minute. At die completion of die 1 -minute pre-mix cyde, about 12.0±0.05kg of Purified Water, USP are sprayed onto the powder bed at a rate of about 40 b0.24kg/πήnute. Immediatdy following the addition of die Purified Water, USP, the unit is granulated for about 5 minutes. The granulated unit is discharged into double polyethylene-lined container loaded into a Glatt bowl whik being passed through a #4 esh screen. The Glatt bowl is loaded into a Glatt TFO-60 fluid-bed drier whh an inlet air temperature setting of about 70 # C±5"C. The unit is dried until a moisture level of * 1.0% is obtained as determined using a ComputracΦ Moisture Analyzer, modd MA5A. The dried granulation is discharged inot appropriately labded, double polyetiiylene-lined drums and reconciled. The dried and reconciled granulation is passed through a Kemutec BetaGrind mill equipped with a 1.5 mm screen and running at approximately 1500 RPM. The milled granulation is collected into appropriately labeled, double polyethylene-lined drums and reconciled. The milled granulation is sampled and tested by Quality Control and released prior to further processing. The rdeased granulation units are charged to a Patterson-Kelley 20 ft 1 V-blender after which they are blended together for about 10 ±1 minutes and then discharged to appropriately labeled, double polyethylene-lined containers. As stated above, NiaspanΦ tablets are formulated from a common granulation which is blended whh appropriate quantities of Metiiocel USP ElOM Premium CR Grade and Stearic Add, NF to achieve the final dosage formulation. Tables IA and IB describe die formulation for each NiaspanΦ tablet strength, 375mg, 500mg, 750mg, and lOOOmg, respectively. Two study groups consisting of deven and fourteen patients each were formed. Blood samples were taken from the patients, and tested for total cholesterol, LDL cholesterol trigrycerides and HDL cholesterol to establish baseline levels from which fluctuations in these lipids could be compared. The patients were then placed upon a regimen of the above discussed tables, totaling approximately 1500mg of racotirac add, once per day before going to bed. After dght weeks of this regimen, die patients were again tested for lipid profiles. The results of die tests conducted at dght weeks, showing die changes in the lipid profiles as a percentage change from die baseline, are reported in the table hereinbdow. Positive numbers reflect percentage increases and negative numbers reflect percentage decreases in this table. TABLEΠ Patient Study Lipid Profde DaU The data reported in TABLE II shows that the LDL levds in the Group A patients had a mean decrease of -13.9% and triglyceride decrease of -18.9% HDL cholesterol levds, the beneficial cholesterol, were raised by 23.0% in this Group. Similar results were obtained with die Group B patients. These studies demonstrate tiiat dosing die sustained rdease formulation during the evening hours or at night provides reductions in LDL cholesterol levels equal to immediate release niacin on a milligram per milligram basis, but superior reductions in triglyceride reductions when compared to sustained rdease formulations dosed during daytime hours on a milligram per milligram basis. Additionally, die increases in HDL cholesterol obtained from dosing the sustained release formulation during the evening or a dght were +23.0% for one group and +25.3% for the other group. Dosing during die evening therefore provides reduction in LDL cholesterol plus significant decreases in trigiycerides and increases in HDL cholesterol with once- a-day dosing. Groups A and B were also tested for liver enzymes (AST, ALT and Alkaline Phosphatase), uric add and fasting glucose levels at the start of the study described hereinabove (to form a baseline) and at two, four and dght week intervals. The results of tiiese tests are listed in TABLES HI- VTI hereinbdow. TABLE HI THE EFFECT OF NIASPANΦ THERAPY ON AST (SGOT) LEVELS (U/L) (1500 mgs dosed once-a-day at night) (n - 28) Weeks of Therapy Whh NIASPANΦ TABLE ΓV THE EFFECT OF NIASPANΦ THERAPY ON ALT (SGPT) LEVELS (U/L) (1500 mgs dosed once-a-day at night) (n - 28) Weeks Of Therapy Whh NiaspanΦ Levd of Significance: p-0.3424 TABLE V THE EFFECT OF NIASPANΦ THERAPY ON AJLKALLNE PHOSPHATE LEVELS (U/L) 0 mgs dosed once-a-day at night) (n - 28) Weeks Of Therapy With NiaspanΦ TABLE VI THE EFFECT OF NIASPANΦ ON URIC ACTD LEVELS (mg/dL) (1500 mgs dosed once-a-day at night) (n - 28) Weeks Of Therapy With NIASPANΦ TABLE Vπ THE EFFECT OF NUSPANΦ THERAPY ON FASTING GLUCOSE LEVELS (mg/dL) (1500 mgs dosed once-a-day at night) (n - 28) Weeks Of Therapy With NIASPANΦ Levd of Significance: p * 0.002 In order to provide a comparison between the state of die art prior to die present invention, and in order to quantify die magnitude of die improvement that the invention provides over die prior art, anod er study was conduαed. This study included 240 patients dosed according to die present invention ss described hereinabove. Compared to this group was the group of patients studied by McKenney et al., as reported hereinabove. The results of this study are reported in TABLE VTJI herdnbelow. TABLE Vm A Comparison of Changes in Liver Function Tests Dosed twice-per-day as described in "A Comparison of the Efficacy and Toxic Effects of Sustained - vs. Immediate • Rdease Niacin in Hypercholesterolemic Patients" by McKenney et al Journal of the American Medical Assodatioit. March 2, 1994; Vol 271, No. 9, pages 672-677. * SR is 'sustained rdease" e Dosed oπce-per-day at night The results of the comparison of the studies reported in TABLE VTfl show that the control group (the McKenney group) had 18 of 23, or 78 percent of the patients dierein drop out of die test because of an increase in their respective liver function tests. The patients withdrew at the direction of die investigator. In comparison, a group of 240 patients treated according to die present invention had zero patients drop out based upon die same criteria for withdrawal The tests results reported above indicate tiiat this sustained rdease dosage form caused no devation in liver function tests (Le. no liver damage), no devations in uric acid and only a small, 7.5% increase in fasting glucose levels which in fact decreased during continued tiierapy. Thus, it should be evident tiiat die compositions and method of die present invention are highly effective in controlling hvperϋpiderma in ιτyperiipidernica, by reducing die lev s of LDL cholesterol, triglyceride and Lp(a) while increasing HDL cholesterol levds. The presem invention is also demonstrated not to cause elevations in liver function tests, uric add or glucose levels for the hyperiipidemics. Fiample II In order to demonstrate the effectiveness of the pharmaceutical combinations and mediods of the present invention over an antihyperiipidemia compound and method, nicotinic add sustained release compositions coated with different HMG-CoA reductase inhibitors are prepared according to die disclosure hereinabove and hereinbdow. The composition ingredients and amounts are listed in Table DCA and DCB and die results of die study are redted in Tables X and XI herdnbelow. TABLE DCA Coated Tablet Composition T ABLE DCB Batch Formulation The core tablet ingredients are compounded together to form sustained release tablets, as described in Example I. The sustained release tablets are tiien coated u follows. The lovastatin, Mediocd E5 and Pluracol E1450 are pre-biended in a polyethylene bag for about 2-3 minutes. The mixture is men passed tiirough a 710mm sieve. A low sheer propeller blade mixer is positioned in a stainless sted beaker containing purified water, USP. The mixer speed is adjusted until a vortex forms. The blended mixture in the polyethylene bag is slowly added to die purified water. If necessary, die mixer speed should be adjusted during the addition of the dry mixture so that the vortex conditions are maintained. Continue mixing until die blended material is completely dispersed. Place the stainless sted beaker on a balance and record gross wdght Calculate net wdght of coating suspension as follows: Net wdght of coating suspension = gross weight of coating suspension - beaker tare wdght Following manufacture of the coating suspension, die sustained release tablets are coated as follows. The Hicoater HCT 48/60 tablet coating machine is first cleaned appropriately pursuant to SOP FM70O-Procedure for the cleaning of Hicoater HCT 48/60 tablet coating machine. The Hicoater HCT 48/60 tablet coating machine should be equipped whh a 9 liter pan, O.όcc gear prop, single gun spray bar, 2.5mm cap and 1.5mm nozzle port Following SOP FM500 - Procedure for die operators of the Hicoater HCT 48/60 tablet coating machine in manual mode, the atomization air pressure should be set to 150 liter/min and e pattern air pressure should be set to 100 Uters/min. Once the atomization air pressure and die pattern air pressure are set die coating suspension is placed on a balance and die suspension feed line is placed in die coating suspension. The suspension return line is dien placed in another container. The low sheer mixer is then placed in the coating suspension and die mixing is started: A period of about 60 minutes should be allowed before proceeding to die next step. After about 60 minutes, die suspension pump and purge lines are switched on. When the lines are filled w h coating suspension, relocate die suspension return line to die coating suspension container. The solution following through the guns should be set to about 40g/min according to SOP FM500. Next, the batch of nicotinic add sustained rdease tablets are loaded into the coating machine. Close me glass door on die machine. Start the Met and exhaust air blowers. Adjust the inlet and exhaust air blower until air flow is I70(±20)cfm and pan pressure negative is between - ' inch and 1 inch. Coat the tablets as follows. Set the pan to JOG at 3.3rpm, 5 seconds on and 30 seconds off Switch on the inlet air heater and adjust to 60°C. Proceed to the film coating phase where the exhaust air temperature reaches 40°C. To further coat, set the pan to run. Increase die pan speed to 15 rpm and start die spray. Calculate die coating end point or target coated tablet wdght as follows: Coating = Starting tablet wdght mg end point x 1.0413 for 750 mg (750mg) tablets Coating = Starting tablet weight, mg end point x 1.0249 for lOOOmg (lOOOmg) tablets Coating - Starting tablet wdght mg end point x 1.0643 for 500 mg (500mg) tablets The coating end point should be approximately ±10% of the target coated tablet wdght range. Continue to apply coating suspension until die end point is reached. Proceed to die next step, which is cooling upon reaching the end point. To cool stop die spray. Set die pan to JOG at 3.3 rpm. Switch off the inlet air heat and allow die coated tablets to cool to approximately 35°C. Stop the pan and turn off die inlet and exhaust blowers. To discharge, use die JOG button on die from of die machine to turn die pan until die trap door is above die surface of the product bed. Position a tared double polyethylene lined container whh desiccant present in the outer bag beneadi die discharge chute. Open the trap door. Rotate the JOG button until coated tablets begin to discharge. Continue to rotate die pan until all the product is discharged from die pan. Stop die pan and remove die container. Then wdgh the coated sustained rdease tablets. Example m A study group consisting of 382 patients was formed. Blood samples were taken from the patients, and were tested for total cholesterol, LDL-cholesterol, trigrycerides and HDL- cholesteroi to establish baseline lev s from which fluctuations in these lipids could be composed. The patients were men placed upon a regimen as follows: Of die 382 patients, 258 patients took approximately 2000mg ofNiaspanΦ, once per day before going to bed, and 122 of 124 patients took concomitandy, once per day at ght before going to bed, approximately 2000mg of NiaspanΦ (two NiaspanΦ 1000 mg tablets) and one HMG-CoA reductase inhibitor tablet as reported in Table X. More specifically, 4 patients took two NiaspanΦ lOOOmg tablets and one fluvastatin 20mg tablet at die same time once per day at bedtime; 12 patients took two NiaspanΦ lOOOmg tablets one lovastatin 20mg tablet at the same time once per day at ght before going to bed; 69 patients took two NiaspanΦ lOOOmg tablets and one pravastatin 20mg tablet at the same time once per day at dght before going to bed; 27 patients took two NiaspanΦ lOOOmg tablets and one simvastatin lOmg tablet at the same time once per day at dght before going to bed; and 10 patients took two NiaspanΦ lOOOmg tablets and one HMG-CoA reductase tablet at die same time once per day at dght before going to.bed. However, during die study, tiiese 10 patients changed between different HMG-CoA reductase inhibitors. Neverthdess, die particular HMG- CoA reductase inhibitors taken by tiiese 10 patients were those recited in Table X. After treatment whh a mean treatment duration of approximately 43 weeks, the lipid profiles of die patients were again tested. The results of die tests conducted, showing the change in the lipid profiles as percentage change from die basdine, are reported in Tables X and XI hereinbdow. The results of the tests conducted, showing the change in clinical chemistry profiles as percentage change from baseline, are reported in Table XII hereinbdow, and showing the number of patients and die % of die total patients in the study tiiat recorded elevations above upper limits of norπud (ULN) for sdected cliracal chemistry parameters, are reported in Tables XJU and XTV herembdow. No inddences or symptoma of myopathy or rhabdomyolysis were described by or observed in die 122 individuals receiving the combination therapy pursuant to this Example LU. TABLE X, NIASPANΦ AND NIASPANΦ /HMG-CoA REDUCTASE INHIBITOR LONG-TERM STUDY EFFICACY DATA: MEAN TREATMENT DURATION - ABOUT 43 WEEKS Table XI also reports results of the tests conducted. More specifically, Table XI reports complete efficacy data (lipid results) for 53 of die 124 patients, who took concomitantiy, once per day at night before going to bed, NiaspanΦ and an HMG-CoA reductase inhibitor, as indicated above in this Example UL Table XI further reports complete efficacy data (lipid results) for 16 patient who took concomitantiy, once per day at dght before going to bed, NiaspanΦ and BAS, a bile add sequestraπt (Le., cholestyramine or coiestipol). Table XI also reports complete efficacy data (lipid results) for 15 patients, who took concomitantiy, once per day at night before going to bed, NiaspanΦ, BAS (a bile acid sequestram, i.e., cholestyramine or coiestipol), and an HMG- CoA reductase inhibitor. TABLE XI UPID RESULTS Meαα Percentage Cbangβ from Baaelioe LONG TERM POPULATION Subgroup Niupu.* Only Niaspan * + Nia»paa * Niaapan* Tool HmgCoΛ +BAS +Bαth Total f of Patterns 269 ISS 53 16 15 LDL F tf nr 269 201 0*1 9 185 1982*2/1 53 2080*4 7 16 207 1*11 1 15 2037*88 (mf/dL) 12 weeks 234 (-10.7*0 84)" I SO (-11 4*1 03)" 53 (-8.6*1 85)" 16 (-11.2*342)" IS (-10.3*332)" 24 weeks 208 (-14 5*098)" 126 (-13 4*1 16)" 52 (-160*2 43)" 16 (-14 8*3.24)" 14 (-182*2 53)" 48 weeks 174 (-21 5*1 10)" 101 (-177*1.28)" 45 (-31 7*2 12)" 15 (-19 5*3 73)" 13 (-186*3 SO)" 72 weeks 140 (-23-2*1 19)" 79 (-18.1*1 S2)" 39 (-31 6*1 73)" 9 (-309*3 83)" 13 (-240*4 12)" 96 weeks 130 (-23 8*137)" 73 (-I7..U1.6S)" 37 (-32-2*2 32)" 7 (-27 8*4.19)" 13 (-33.0*4.18)" HDL μ t -ι ~- 269 434*06 185 43.6*0.7 53 42.7*1 4 16 42 5*2.3 15 440*2 2 (ma/4L) 12 weeks 234 (19.6*1.09)" ISO (20.2*136)" S3 (1S. 2.I6)" 16 (31.1*4.40)" 15 (173*3.83)" 24 weeks 20S (24.9*131)" 126 (2S 1*1 74)" 52 (22 S*237)" 16 (387*302)" 14 (164*509)" 13 (17.6*474)" 48 weeks 174 (279*1 56)" 101 (29.0*2.05)" 4$ (228*3.07)" 15 (36.2*5.25)" 72 weeks 140 (2S S±1 54)" 79 (27 8*2 15)" 39 (22-2*257)" 9 (37.4*6.31)" 13 (16 5*344)" 96 weeks 130 (2 1*1 68)" 73 (32 1*2.46)" 37 (24.7*2-36)" 7 (31-2*944)* 13 (232*4.00)" S3 285-2*49 16 2820*106 272 8*9.1 Total Chofcatβrol Bstrhnt 269 276.0*2 1 185 2730*24 53 (-6.9*1.50)" 16 (-6.3*2-23)" (-7.0±2.47)» (nsML) 12 weeks 234 (-7-2*063)" ISO (-7.4*076)" 24 weeks 204 (-9-2*06)" 126 (-7.8*0.88)" 52 (-11.8*1.92)" 16 (-8.2*2-20)" (-13.7*1.96)" 48 weeks 174 (-14.0*0.87)" 101 (-10.5*0.94)" 45 (-23.1*1 77)" IS (-113*2.82)" (-13.4*2.42)" 72 weeks 140 (-IS.7*0 7)" 79 (-11.4*1 IS)" 39 (-24.1*1.41)" 9 (-13.9*4.51)" (-182*2.99)" 96 week* 130 (-IS.fel.10)" 73 (-10.0 1. IS)" 37 (-23.8*2.05)" 7 (-15.1*2.62)" (-23.1*3.4$)" TABLE XI (cMtiMMd) LIPID RESULTS Mean Percentage Change from Bamliiw LONG TERM POPULATION Total f of Patarts 269 185 53 16 65 Tngryccmlcs Besdoe 269 1577*4 1 185 1559*50 1722*93 16 161 5*17 7 124 8*11 0 (-234*378)" 16 (-19 3*632)" (-189*624)" (*β αL) 12 weeks 234 (-21 1*1 80)" 150 (-208*232)" 24 weeks 208 (-21 7*2 13)" 126 (-209*265)" ( 23 5*4 34)" 16 (-203*798)* ( 23 8*104)* 48 weeks 174 (-242*2 SO)" 101 (-235*291)" (-304*605)" IS (-127*978) (-222*627)" 72 weeks 140 ( 28 1*2 75)" 79 (-265*367)" (-374*3 53)" 9 (-1 6*207) (-287*571)" 96 weeks 130 (-258*2 86)" 73 (-264*380)" (322*4 10)" 7 (5 13*21 4) (-20 5*8 32)* 344*1 16 324*3 5 25 0*2 2 VLDL BasCr oe 269 31 6*08 185 312*1 0 (-238361)" 16 (-200*623)" (-187*6 31)" (mg dL) 12 weeks 234 (-212*1 80)" ISO (-206*2 3S)" (-23 7*4 30)" 16 (-204*798)* (-239*104)* 24 weeks 208 (-21 7*1 80)" 126 (-209*269)" (-294*6 57)" IS (-13 3*9 80) (-22 5*635)" 48 weeks 174 (-240*2 S8)" 101 (-23 4*291)" (-374*3 53)" 9 (10 5*31 0) (-28 6*5 70)" 7 ' 140 (-272*3 14)" 79 (-262*36$)" *2 86)" 73 (-25 8*3 85)" (-320*4 12)" 7 (-1 7*224) (-20 *809)* 96 ι 130 (-2S 8 699*023 16 696*0 51 640*0 34 TC to HDL Rabo Basdwe 269 663*009 185 6 52*0 10 (-180*1 81)** 16 (-27 1*326)" (-194*387)" 12 weeks 234 (-21 0*088)" ISO (-21 6*1 08)" (-267*225)" 16 (-334*248)** (-240*403)" 24 weeks 208 (.259*099)" 126 (-24 8*121)" (-37 5*2 37)" IS (-330*4 18)" (-24 5*461)" 48 weeks 174 (-31 3*1 13)" 101 (-29 1*1 32)" (-369*1 87)" 9 (-360*5 32)" (-287*421)** 72 weeks 140 (-31 8*1 IS)" 79 (-294*1 51)" 0 1*1 64)" (-384*1 82)" 7 (-33 5*3 85)" (-372*3 10)" 96 weeks 130 (-334*1 16)" 73 (-3 1 185 4 75*008 5 12*020 16 5 16*047 4 80*0 3 LDL to HDL Baacttne 269 485*008 ISO (-24 7*129)" (-192*2 12)" 16 (-31 2*394)" (-21 8*4 50)* • 12 weeks 234 (-237*104)" 126 (-290*1 42)" (-29 8*2 59)" 16 (-382*306)" (-280*394)" 24 weeks 208 (-299*114)" 387*4 61)" ( 286*544)" 100 (-34 5*1 58)" H3 6*2 54)" IS (- 48 weeks 173 (-368*130)" 79 (-34 3*1 77)" (-42 9*208)" 9 (-494*2 66)" (-33 5*5 19)" 72 weeks 140 (-376*132)" 73 (-35 8*1 92)" (-450*222)" 7 (-44 3*362)" (-45 3*3 80)" 96 weeks 130 (-398*137)" Note Obaαved Values * S E (percentage change *5 ti ) TABLE XI (cβtSiwicd) IΛTUf KKMJL i a Mean Percentage Change from τHiιι- LONG TERM POPULATION a Subgroup Niaapaa* Oaiy Niaapaa* + Niaapaa* Niaspan* Total HaagCoA +BAS +BoΦ TotalS of PaHeato 269 I8S 53 16 15 Apolipopnton B Baseline 244 148 1*123 165 145 7*1 41 48 155 8*2 85 16 149 3*603 15 1492*4 53 (mg/dL) 12 weeks I3S (J9.S*I 02)" 76 (-11 5*1 38)" 37 (-62*206)** 13 (-114*290)" 12 (-80*282)" 24 weeks 133 (-14 0*1 06)" 71 (-12 6*1 37)" 36 (-16 1*2 56)" 14 (-13 7228)" 12 (-166*248)* • 48 weeks 123 (-18 7*1 14)" 70 (-15 4*1 33)" 30 (-262*2 60)" 11 (-192*3 14) 12 (-18 5*344)" 72 weeks 43 (-202*1 85)" 31 (-160*1.95)" 11 (-322*222)" 0 — 1 ( 19 3) 96 weeks 0 — 0 "~" 0 0 0 Lp(a) jjBttdioc 244 367*222 165 360*2.64 48 344*5.29 16 496*895 15 38 5*933 (mg/dL) 12 weeks 139 (-275*2 19)" 78 (-288*269)" 36 (.287*4.44)" 13 (-282*601)" 12 (-149*109) 24 weeks 133 (-28 7*229)" 72 (-304*2 70)" 35 (-280*531)" 14 (-298*599)" 12 (-19 5*100) 48 weeks 131 (-293*466)" 74 (-363*2 73)** 32 (-192*17.6)" 12 (-240*5 85)" 13 (-190*701)* ) 72 weeks 44 (-33.0*3.84)" 29 (-31 5*4 84)** 12 (-384*7.41)" 0 3 (-24 7*126 0 96 weeks 0 - 0 — 0 —~ 0 Values ± S-E. (|»eπ-^«luMge *S.E). Individual dais m provide. on .UP diskette. Note: The - indicates *ai no ■ needs have been eoltecled far that visit Obsαved » ' fl M — .i ifirsm i Λ, i.0.01; .natchcd-pβir teat Table XII reports clinical chemistry parameters (liver function) for all 124 patients, who took concomhantty, once per day at night before going to bed, NiaspanΦ and an HMG-CoA reductase inhibitor. Table XII further reports clinical chemistry parameters (liver function) for 22 patients, who took concomitantiy, once per day at night before going to bed, NiaspanΦ and BAS (a bile acid sequestrant, i.e., cholestyramine or coiestipol). Table XII also reports clinical chemistry parameters (liver function) for 17 patients who took concomitantiy, once per day at night before going to bed, NiaspanΦ, BAS (a bile acid sequestrant, i.e., cholestyramine or coiestipol), and an HMG-CoA reductase inhibitor. TABLE Xll (c CHEMISTRY PARAMETERS MEAN PERCENT CHANGE FROM BASELINE LONG TERM POPULATION LT Total Niaapaa OaJv Niaapaa a Niaapaa* BAS Niaapaa* Bo* HMO-CoΛ a MetatSB- a Maaa±SB. a Maaa ±S.B. a Meaa ± SB. a Maeα ± SB. D«B4*(aaa/dL) 617 012*0.002 4)4 0.12*0.002 124 0.12*0004 22 013*0013 17 010*0.007 I2 M(U 311 (17*1.47)** 1)1 (81*176)** 121 (8.7*3.06)" 22 (102*6.30) 17 (18.0*8.62) 48we*s IN (26.4*6 6" 240 (266*1024)** 101 (24.4*423)" 20 (24.1*768)" 1) (40.1*12.24)" 96 weeks 113 (272*1.32)" 7J (178*422)" 37 (406*4.77)" 7 (167*766) 13 (490*1436)" Basβhαc 617 )l 2*0.78 4)4 )12*092 124 )22*|72 22 493*370 17 436*320 12 weak* 311 (64*0.84)** 1)1 (72*l.07)** 121 (49*1 )9)** • 22 (41*2.19) 17 (34*3.39) 48 waits 176 (86*107)" 240 (87*134)" 101 (86*190)** 20 (7.2±) 23) 1 ) (10.1*706) Mweaks 132 () 1*2.00)" 75 () 4*232)* 37 (66*) 23) 7 (31*3 )8) 13 (26*3))) Note: Vahws era >ajiii-f net awdiβwaalc ■ami lahαπKKMa. Ifaut, tht B oaaarvad vaata | i niati i fcr iamijytiva pupowa only. - • ?iH»fira1a1j-f f **Si| aaiacaaltfa (0.01 atcaad«warl4aat ** Otaa d Vakas *SE- fct B aaali>a(awaa paroaal chewy 6— Baialii * 8 t ht «*L» 12.48 aad 96) In Tables X-XH, positive numbers reflect percentage increases and negative numbers reflect percentage decreases. Table XHT reports the number of patients and die % of die total patients in die study that recorded elevations above upper limits of normal (U N) for selected clinical chemistry parameters. More particularly, Table XHI reports the number of patients and die % of the 124 patients, who took concomitantiy, once per day at night before going to bed, NiaspanΦ and an HMG-CoA reductase inhibitor, that recorded elevations above ULN for selected clinical chemistry parameters. Table XTH further reports die number of patients and die •/• of die 22 patients, who took concomitantiy, once per day at night before going to bed, NiaspanΦ and BAS (a bile acid sequestrant, i.e., cholestyramine or coiestipol), that recorded elevations above ULN for selected clinical chemistry parameters. Table Xm further reports die number of patients and die */• of die 17 patients, who took concomitantiy, once per day at night before going to bed, NiaspanΦ, BAS (a bile acid sequestrant, i.e., cholestyramine or coiestipol), and an HMG-CoA reductase inhibitor, that recorded elevations above ULN for selected clinical chemistry parameters. TABLE Xm TREATMENT EMERGENT ABNORMALITIES IN SELECTED CHEMISTRY PARAMETERS LONG TERM POPULATION LT Total 1 Niaspan* Niaspan** Niaspan* Niaspan* Only HMG-CoA *BAS A Both Total Patient* 617 454 124 22 17 AST >Normai 70(11%) 44(10%) 17(14%) 5(23%) 4(24%) (miU/ L) >1.3xULN 28(5%) 17(4%) 6(5%) 3(14%) 2(12%) >2xULN 5 1%) 3(<1%) 1(<1%) 1(6%) 0 >3xULN 1(<1%) 1(<1%) 0 0 0 ALT >Normai 44(7%) 23(5%) 14(11%) 2(9%) 5(29%) (miU/mL) >1.3xULN 15(2%) 4(<1%) 5(4%) 2(9%) 4(24%) >2xULN 3(<1%) 1(<1%) 2(2%) 0 0 >3xUI_N H<1%) 0 K<1%) 0 0 AlfcPhoβ. >Normaέ 17( 3%) 9(2%) 3(2%) 2(9%) 3(18%) (miU/inL) >1.3xULN 3(1%) 0 2(2%) 1(5%) 0 LDH .Noπnal 94(15%) 60(13%) 23(19%) 8(36%) 3(18%) (miU/mL) >1.3xULN 6(<l%) 4(<1%) K<1H) 0 1(6%) Fasting Glue >Nomat 111(18%) 67(1S%) 36(28%) 4(18%) (24%) (mg/dL) >1.3xULN 6(<1%) 3(<1%) 3(27%) 0 0 Uric Acid iNormal 89(14%) 49(11%) 28(23%) 7(32%) 5(29%) (miU/mL) >1.3xϋLN 5(<1%) 3(<1%) 1(<1%) 0 1(6%) Total Bit iNocmβl 10(2%) 5(1%) 4(3%) 0 1(6%) (mgdL) >lx3.ULN 2(<l%) K<1%) 1(<1%) 0 0 Amviaββ >Nc*mrJ 1S(3%) 11(2%) 7(6%) 0 0 (mgdL) >1.3xULN 6<<1H) 5(1%) l(<l%) 0 0 >2xULN 1(<IH) l(tlH) 0 0 0 Phoephonis ( vOiaTMi 159(26%) 96(21%) 47(3t%) 9(41%) 7(41%) (mgdL) OJOm≠Λ. 1*3%) 14(3%) 4(3%) l(S%) 0 NolK Ptll i-Btltagas eB OHBUMlBQ ftoαi the total number of panena n each ceriums. Abnormal bvw MimteiaTPi riant 3512 an not included in tha tabte as tho ala srteouHtedattloeailκ MpetaL Refer to the initial Saάt Update (Voi J. 12-1337) Table XTV reports the number of patienu and die % of the total patienta in the study that recorded elevations 2 or 3 times above upper limits of normal (ULN) for the AST and ALT clinical chemistry parameters. More particularly, Table XTV reports die number of patients and the % of the 124 patients, who * took concomitantiy, once per day at night before going to bed, NiaspanΦ and an HMG-CoA reductase inhibitor, that recorded elevations which were 2 or 3 times above ULN for the AST and ALT clinical chemistry parameters. Table XTV is consistent with that reported in Table XHT. TABLE XIV LONG-TERM STUDY SAFETY DATA LIVER FUNCTION TESTS NiaspanΦ + NiaspanΦ HMG-CoA Reductase Inhibitor N-454* N-124" AST > 2xULN 3 (<1%) 1 (<1%) AST > 3xULN 1 (<1%) 0 ALT > 2xULN I (<l%) 2 (1.6%) ALT > 3xULN 0 1 (<1%) •Mean follow-up approximately 52 weeks ••Mean follow-up approximately 43 weeks The data reported in Tables XI-XTV evidences dial a pharmaceutical combination of the present invention, e.g., sustained release nicotinic acid and an immediate release HMG-CoA reductase inhibitor, given concomitantiy, once per day at night before bedtime, is effective in reducing serum lipid levels, and in particular total cholesterol, VLDL-cholesterol, LDL- cholesterol, trigiycerides, apolipoprotein B and Lp(a) levels, and is effective in reducing d e total cholesterol to HDI^choiesterol ratio and die LDL-cholesterol to HDL-cholesteroi ratio. The data reported in Tabtos XI-XTV also evidences that a pharmaceutical combination of the presem invention, e.g., msramnd release nicotinic acid and an immediate release HMG-CoA reductase inhibitor, given concomitantiy, once per day at night before bedtime, is effective in enhancing or increasing HDL-cholesteroi levels. Also, it is believed that the data reported in Tables XI-XTV evidences that a pharmaceutical combination of the present invention, e.g., sustained release nicoύnic acid and an immediate release HMG-CoA reductase inhibitor, given concomitantiy, once per day at night before bedtime, is more effective in reducing LDL-cholesterol levels dan when either sustained release nicotinic acid or an immediate release HMG-CoA reductase inhibitor are given in similar dosages once per day at night before going to bed, but alone. Still further, it is believed that the data reported in Tables XI-XTV evidences that a pharmaceutical combination of the presem invention, e.g., sustained release nicotinic acid and an immediate release HMG-CoA reductase inhibitor, given concomitantiy, once per day at night before bedtime, is more effective in increasing HDL-cholesteroi levels than when an immediate release HMG-CoA reductase inhibitor is given by itself in a similar dosage once per day at night before going to bed. The data reported in Tables XI-XTV also evidences that such concomitant therapy, e.g., sustained release nicotinic acid and an immediate release HMG-CoA reductase inhibitor, given once per day at night before bedtime can be administered and die benefits achieved widiout inducing hepatotoxicity, myopathy or rhabdomyolysis, or at least widiout inducing in an appreciable number of individuals hepatotoxicity, myopathy or rhabdomyolysis to such a level that would require discoritinuation of such tiierapy. Moreover, the data reported in Table XII evidences that such concom am therapy, e.g., sustained release nicotinic acid and an immediate release HMG-CoA reductase inhibitor, given once per day at night before bedtime can be administered and die benefits achieved widiout adversely effecting glucose metabolism or uric acid levels, or widiout adversely effecting in at least an appreciable number of individuals glucose metabolism or uric acid levels to such an extern that discontinuation of such therapy would be required. Based upon die foregoing disclosure, it should now be apparent that die pharmaceutical combinations, formulations, compositions and mediods and die use diereof described herein will carry out the objectives set forth hereinabove. It is, therefore, to be understood that any variations evident in die pharmaceutical combinations, formuiationa, compositions and methods fall within the scope of die claimed invention and, thus, die selection of specific component elements can be determined widiout departing from the spirit of the invention herein disclosed and described. For example, sustained release excipients, binders and processing aids according to the present invention are not necessarily limited to those exemplified hereinabove. Thus, the scope of the invention shall include all modifications and variations that may fall whhin the scope of die attached claims. Having described my invention, I claim:

Claims: CLAIMS: 1. A method of reducing die capacity of nicotinic acid to provoke a flushing reaction in an individual when nicotinic acid is orally adininistered in an effective lipid-altering amount as a single dose once a day during die evening hours or before or at bedtime, comprising orally pretreating die individual with a flush inhibiting amount of a flush inhibiting agent for a sufficient period of time prior to initiating die administration of the nicotinic acid in die individual; and orally administering the nicc*tinic acid to die pretreated individual in an effective lipid-altering amount as a single dose once a day during the evening hours or before or at bedtime, whereby the capacity of die nicotinic acid to provoke a flushing reaction in the pretreated individual is reduced. 2. A method of claim 1, wherein said method includes die further step of orally administering to die pretreated individual an HMG-CoA reductase inhibitor in an effective lipid-altering amount. 3. A method of claim 2, wherein said HMG-CoA reductase inhibitor oral administartion is conccinitantiy with said nicotinic acid oral administration. 4. A method of claim 2, wherein the HMG-CoA reductase inhibitor is an extended release form or in an immediate release form. 5. A oiethod of claim 2, wherein said HMG-CoA reductase inhibitor is selected front die group rnnti sting of atorvastatin, cerivastatin, flavastatin, lovastatin, pravastatin and smwastatin. 6. A noetic of claim 1, wtereω d» flush inhibiting geΛ nonsteroidal anti-iiiflajiimatory agent. 7. A method of claim 6, wherein the nonsteroidal anti-inflammatory agent is selected from the group consisting of indomethacin, sulindac, etodolac, aspirin, salicylate salts, ibuprofen, fluribprofen, fenoprophen, suprofen, benoxaprofen, ketoprofen, carprofen, naproxen, sodium naproxen, aclofenac, diclofenac, fendofenac, tolmectin, zomepirac, meclofenamate, mefanamic add, oxyphenbutazone, phenyibutazone and piroxicam 8. A method of claim 1, wherein the flush inhibiting agem is aspirin. 9. A method of claim 8, wherein said oral adniinistration of the aspirin comprises orally adininistering the aspirin in one to four doses per day during said pretreatment. 10. A method of claim 8 wherein said method includes die further step of orally administering die aspirin as the flush inhibiting agent in an amount of between about 80 mg and 1000 mg daily during said pretreatment. 11. A method of claim 2, wherein the flush inhibiting agent is aspirin. 12. A method of claim 11, wherein said oral administiation of the aspirin comprises orally adniiniatering the aspirin in one to four doses per day during said pretreatment. 13. A method of claim 11, whete said oral of die aspirin comprises orally ariminitfcring the aspirin in one or two doses per day during said pretreatment. 14. A method of claim 11, wlβre said indudes die further step of oπdly admir * ***"^ die aspirin as the flush inhibiting agent in an amount of between about 80 mg and about 1000 mg daily during said pretreatment. 15. A method of claim 11, wherein said method includes die further step of orally administering die aspirin as the flush inhibiting agent in an amount of between about 80 mg and about 650 mg daily during said pretreatment. 16. A method of claim 11, wherein said method u ιuies ti>» further step of orally administering die aspirin as the flush inhibiting agent in an amount of between about 80 mg and about 325 mg daily during said pretreatment. 17. A method of claim 11, wbierem ?aid method includes u^ fhrther step of orally adntinistering a n x»tinic acid compound to the μicϋcaled ϋxhvidual in an effective lipid-altering amount. 18. A method of claim 17, wherein the nicotinic acid compound is sdected from die group consisting of nicoturyi alcohol tartrate, d-gtuάtol hexanicotinate, aluminum nicotinate, niceritroi, d, 1-alpha-tocopheryi nicotinate, 6-OH-nιcotmic add, nicotinaria add, nicotinamide, nicotinamide-N-oxide, 6-OH-nicotinamide, NAD, N-medxyi-2-pyrridine-8- carboxamide, N-metilyi-nicotinamide, N-ribosyi-2-pyridone-5-carboxide, N-methyi-4-pyridone-5- carboxamide, bradilian, sorbin ate, hexanicite, ronitoi, and lower alcohol esters of nicotinic add. 19. A method of claim 11, wherry said niethod incluo^es d» furtiier step of orally attminislrring a cholesiTTamine to the pretreated individual in an effective lipid- altering amount 20. A method of claim 11, wherein said method includes die further step of orally administering a coiestipol to die pretreated individual in an effective lipid- altering amount.

Inventors: CEFALI EUGENIO A, CEFALI, EUGENIO, A.
Applicants: KOS PHARMA INC, KOS PHARMACEUTICALS, INC.
Application year: 1998
Main classification: A61K31
IPC codes: A61K31