Cardiac treatment system for sensing and responding to heart failure

Abstract: A pacing system for determining a heart failure condition such as left ventricular dysfunction in a patient are provided, based upon obtaining information from cardiac signals, which information is processed and examined for a indication of the onset or progression of LVD. Since LVD is generally characterized by conduction disorders and other body responses calling for different heart rates during exercise, an examination of sensed cardiac signals is utilized to obtain data reflective of an LVD condition. In one embodiment, a QT rate responsive pacemaker (50) is utilized, wherein variations in QT interval corresponding to heart rate are detected and stored (40, 42), and then periodically analyzed (44; 74; 86) to detect changes of sufficient magnitude to indicate onset of LVD. In another embodiment, changes in lower natural rate at nighttime or rest are monitored ad analyzed for detection for a trend indicating LVD (82-86). Other cardiac signal parameters, such as T-wave amplitude changes during exercise, and QRS duration changes, can also be processed to obtain information from which LVD can be determined. When a LVD indication is made, the system responds automatically so as to take initial steps to treat the condition. Thus, in one embodiment, the control of pacing rate is altered so as to be better responsive to patient exercise (94). In another embodiment, 3- or 4-chamber pacing is initiated. In yet another embodiment, drug therapy is automatically administered.

Description: The invention relates to an implanatable system for pacing a patient's heart and for determining a condition of heart failure according to the precharacterizing portion of claim 1. The problem of treating patients with heart failure is gaining increasing attention. An implantable system according to the precharacterizing portion of claim 1 is disclosed in EP 0 487 429 A1. EP 0 467 695 A2 discloses an apparatus for treating a patient who is at risk of suffering a myocardial infarction. The apparatus according to EP 0 467 695 A2 comprises means for sensing electrical activity of the patient's heart, means responsive to electrical activity sensed by said sensing means for recognizing a myocardial infarction, and means for supplying a thrombolytic drug to the patient when said recognition means recognizes a myocardial infarction. EP 0 804 939 A2 discloses an implantable rate responsive pacemaker using the physiological demand parameter to determine the classification of a patient, that means his degree of congestive heart failure. For this purpose, the parameter is monitored for extended time periods, e.g. several days, to determine the levels for said parameter corresponding to different levels of physical activity. The variation in these levels is then translated into corresponding classification using a pre-selected criteria. EP 0 541 338 A1 discloses an implantable cardiac function monitor and stimulator for diagnosis and therapy delivery. Said monitor/stimulator according to EP 0 541 338 A1 comprises intracardiac sensing means for sensing haemodynamic indicators of contractile state in at least one ventricular chamber of the heart, means coupled to said sensing means for developing a control signal varying as a function of said haemodynamic indicators, patient therapy means having at least one stimulating electrode for applying stimulating pulses to tissue, and means for applying said control signal to said patient therapy means, for changing said contractile state. A heart failure may be manifested as left ventricular dysfunction (LVD), congestive heart failure (CHF), or other forms. For patients with LVD, the ejection fraction from the left ventricle is reduced, and the ability of the stroke volume to respond to exercise is limited. While the disease of the heart may proceed in different ways, the result is a degenerative reduction in cardiac output. For example, LVD may be produced by a degree of left bundle branch block, leading to loss of synchrony between the left atrium and the left ventricle. Whatever the progress of the disease, cardiac output is reduced, and the heart responds so as to increase cardiac output toward a normal level primarily by heart rate increase. The rate increase may be manifested in several different ways, e.g., there may be an increase in the daily lower spontaneous rate, i.e., the nighttime rate when the patient is at rest. Further, the changed conductive patterns which may form the basis of the LVD can lead to changes in the cardiac signal, e.g., an increased width of the depolarization signal, or QRS. Further, since the body is calling for an increase in blood supply, patients with LVD are also known to have elevated levels of catecholamines at rest, which induces a higher heart rate at rest. In turn, the QT interval for such a patient is affected by the catecholamine level, and thus has a changed pattern during exercise as well. These patients have a decreased QT response, or smaller change in QT, during exercise, such that the QT interval shortening during exercise is smaller than that found normally. Although QT interval is influenced independently by heart rate alone, as well as by exercise and catecholemines, it is not known to what extent each of these factors or both are responsible for the changed QT response to exercise in LVD patients. However, it is known that patients with LVD clearly have a different pattern of QT interval shortening during exercise. As a consequence of the above observations, the basis for this invention is obtaining information from cardiac signals for deriving an indication of LVD, or onset of LVD. It is seen that for an implanted device such as a cardiac pacemaker, which can sense cardiac signals and process heart rate (or R-R interval), QT interval, and QRS length, as well as QRS and P-wave morphology, information can be obtained for tracking changes in left ventricular function, and in particular for indicating progression toward some degree, or form of left ventricular dysfunction. In particular, a rate responsive pacemaker which uses QT interval as the rate indicating parameter, such as pacemakers made by Vitatron Medical, the assignee of this invention, can be adapted to provide information relating to left ventricular hemodynamic performance, and for indicating the onset of LVD. In such a QT rate responsive pacemaker, there is provided an algorithm for automatically adjusting the rate responsive parameters, i.e., the correlation function between QT and desired rate. This adjustment is suitably done on a daily basis where the pacemaker measures a slope of the correlation function at the lower rate limit, and adjusts the QT-rate function between lower rate limit (LRL) and upper rate limit (URL) accordingly. See U.S. Pat. No. 4,972,834, incorporated herein by reference. If such changes are stored and analyzed for a trend, progress toward LVD can be indicated. Likewise, if it is found that the patient heart rate is not dropped to the programmed LRL during nighttime, such that the spontaneous lower rate has had an upward progression, this trend can also be used as an indicator of the onset of LVD. Since LVD is generally symptomatic of cardiac conduction disorders, other variations in sensed cardiac signals may also be used for making an indication of LVD, or for corroborating progression toward LVD. For example, in a patient with onset of LVD, the evoked T-wave amplitude may not increase in a normal manner during exercise. Thus, in normal patients with healthy hearts the evoked T-wave amplitude increases up to about fifty percent during exercise, an increase which may correlate with stroke volume. A change in the variation of T-wave amplitude with respect to exercise, and consequent heart rate, can be easily measured and tracked in a QT rate responsive pacemaker, or any pacemaker adapted to sense and recover the T-waves. Likewise, as noted above, changes in QRS duration (width) and/or morphology may also be detected and tracked for detection of a trend. What is needed in patients with progressive LVD or other types of heart failure is the availability of data from which a cardiologist can properly and accurately chart the progression, determine the nature of the heart failure, and be able to implement the optimal treatment in a timely fashion. Thus, physicians need a better means of diagnosing development of, or onset of LVD, in order to provide appropriate treatment. Modern pacemakers, and indeed even 4 chamber pacemakers for treating heart failure by bi-ventricular pacing, have heretofore not provided any such means for collecting data concerning the onset of LVD. Rather, the procedure has been essentially limited to direct examinations of the patient, which are time consuming and costly, and which cannot be repeated with a desired frequency so as to provide accurate trend information. Another problem existing in the art today is that patients with implanted DDD pacemakers who develop LVD, may be in a situation where ventricular pacing produces a deleterious effect. Thus, if the pacing may cause a mechanical activation sequence which is abnormal, in which case it would reduce the cardiac output. For example, in patients having left bundle branch block, it has been reported that with normal pacing there may be risk in aggravating activation sequences. See "Four Chamber Pacing in Dilated Cardiomyopathy," Cazeaq et al., PACE, Vol. 17, November 1994, Part II. In view of the above, it is seen that there is a substantial need in the art for a pacemaker or other implanted device having the capacity to identify the onset of cardiac heart failure, and in particular LVD, and to provide such indication to the patient and the patient's physician, or to provide for an appropriate automatic response to treat the changing patient condition. In view of the above need, it is an object of the present invention to provide an improved system for monitoring patient cardiac signals and processing such signals to provide data from which the onset or progression of an LVD condition is determined. According to the invention, this object is achieved by an implantable system according to claim 1. Preferred and advantageous embodiments of the system according to the invention are subject matter of claims 2 to 9. Embodiments of the present invention will now be described by way of example with reference to the accompanying drawings. Figure 1(A) is a diagram illustrating different QT-rate correlation functions for a rate responsive pacemaker; Figure 1(B) is a diagram illustrating changes in the relationship between QT and rate, as may occur with the onset of LVD; and Figure 1(C) is a set of curves illustrating another way in which the QT-rate relationship may change with the onset of LVD. Figure 2 is a schematic diagram illustrating an implanted pacemaker device and four leads for pacing and sensing in the four cardiac chambers, and also showing a drug dispensing device for supplying a drug for treating a detected form of LVD. Figure 3 is a block diagram of a pacemaker incorporating the features of this invention. Figure 4 is a simplified flow diagram showing the primary steps of monitoring cardiac signals, processing the cardiac signals and obtaining and storing data representative of changes in the cardiac signals; identification of onset or progression of LVD; and automatically responding by providing a treatment for the identified LVD. Figure 5 is a flow diagram illustrating collection of QT-rate data, processing such data to determine changes in the QT-rate correlation, and identification of onset of LVD as a function of determined QT-rate changes. Figure 6 is a flow diagram of the primary steps carried out by an embodiment of this invention for obtaining measures of nighttime patient lower rate, for accumulating such lower rate data and for identifying LVD as a function of such accumulated lower rate data. Figure 7 is a flow diagram illustrating the primary steps in responding to an indication of LVD by adjusting the blended response of a dual sensor rate responsive pacemaker, so as to optimize pacing rate response to exercise for an LVD patient. Before turning to a more detailed description of the drawings it has to be mentioned the following: While the invention is illustrated primarily by reference to LVD, it is to be understood that it is applicable to various forms of heart failure, including left heart conduction disorders such as LBBB, and other forms of heart dysfunction. Referring now to Figure 1(A), there is shown a set of curves illustrating the relationship between the parameter QT and rate, for a rate responsive pacemaker where QT is the rate-indicating parameter. Thus, each of the curves shown is a separate rate responsive function, or correlation function for determining rate as a function of sensed QT. Curve 1 is the least aggressive of the curves, in the sense of providing a change in rate for a given change in QT. As seen, curve 2 is somewhat more aggressive, and the third curve is the most aggressive of the three. In a QT pacemaker where the lower rate limit (LRL) and upper rate limit (URL) are programmed to predetermined values, the dynamics of the correlation function can be changed to accommodate sensed changes in the patient QT-rate relationship. See U.S. Patent No. 4,972,834, hereby incorporated by reference, which shows a technique for adjusting the slope at LRL or URL, where slope is the incremental difference in pacing interval divided by the incremental sensed change in QT. In relation to this invention, it is anticipated that this correlation function will need to be changed in some manner for a patient who receives a pacemaker without significant left ventricular dysfunction, but who later progresses toward some stage of LVD. Referring to Figure 1B, there is shown a set of curves which indicate a changing relationship between QT and patient heart rate as a patient progresses toward some form of LVD. Curve 4 is presented as a curve for a normal patient, with a first value of QT at LRL (e.g., 70 bpm). After some time and deterioration of normal cardiac function, the curve may change to that shown at 5, corresponding to a smaller QT at LRL. Such a smaller or reduced QT would correspond to the increased catecholamine level, as mentioned, above. Curve 6 represents a condition more advanced toward LVD, showing an even smaller QT at LRL. It is to be seen that if the patient's cardiac condition results in such a changed relationship between QT and heart rate, a QT rate responsive pacemaker that started out with the correlation function represented by curve 4, would need to have the correlation function adjusted in order to correspond to the patient's changed condition. Referring to Figure 1(C), there is shown another set of curves that represents changes in a patient's QT-rate relationship, as the patient progresses toward LVD. Curve 7 is a starting condition which corresponds approximately to curve 4 as seen in Figure 1B. After some time, it is determined that the patient's QT-rate relationship is as represented by curve 8. As seen, under these conditions, the patient's spontaneous rate does not in fact drop below about 70 bpm, and a different characteristic is exhibited for the relationship between QT and rates of about 70 and an upper limit of about 110 bpm. After even more progression toward LVD, the patient condition is as represented in curve 9, where the patient's lowest spontaneous rate, at nighttime or other rest, is about 80 bpm. Here, in comparing curves 7 and 9, it is seen that there is sufficient difference in the QT-rate relationship for the patient that it can be concluded that the patient has come to the onset of some form of LVD. Such a conclusion can be derived either by comparing the lowest rate (80 for curve 9, compared with 60 for curve 7), or by comparing the slope of the curves. Thus, comparing curve 9 with curve 7, the change in QT between a rate of 80 and a rate of 110 is significantly less. Referring now to Figure 2, there is shown a schematic diagram representing the system of this invention in relation to a patient's heart. A pacemaker, or other implantable device such as a combined pacemaker-cardioverter defibrillator 50, is a standard available pacemaker for generating pacing pulses and for sensing cardiac signals. A connector block 51 receives the proximal end of four leads, designated at 52, which go to respective locations in the four respective chambers of the heart. It is understood that the invention may normally be practiced with only a dual chamber pacemaker, or even a single chamber (VVI) pacemaker. For a 3- or 4-chamber pacemaker, at the time of implant it may be desired to operate the pacemaker only as a dual chamber pacemaker with lead connections to the right atrium and right ventricle, the pacemaker being adapted to be connected with additional leads for pacing and sensing in the left ventricle and left atrium when and as LVD is determined. In Figure 2, a first of the leads is positioned so that its distal tip is in the right ventricle, and carries bipolar electrodes 54, 55. As is known, the lead arrangement may be unipolar, using only a far distal tip lead, in combination with the electrode case as the indifferent lead. A second lead is positioned so that its distal end is in the right atrium, carrying electrodes 56, 57. Another lead is positioned via the coronary sinus for pacing and sensing in the left atrium, having electrodes 58, 59 positioned at about its distal end. A fourth lead is illustrated positioned to pace and sense in the left ventricle, via the coronary sinus and the great vein, having electrodes 60, 61. Although such four-chamber capacity is not necessary for practice of the invention, and indeed detection of LVD can be determined by sensing only signals derived from the right ventricle, a four-chamber system is illustrated so as to indicate the scope of the invention. Additionally, a drug delivery system, shown at 65, is in communication with pacemaker 50, and can be automatically activated to release an appropriate drug for treatment of LVD whenever LVD is detected. The link between the device 50 and the drug dispensing unit 65 may be either by direct wire connection or may be by telemetry. Figure 3 is a functional block diagram of an implantable pacemaker of the type in which the present invention may be practiced. The disclosed embodiment takes the form of a microprocessor controlled device. However, it is believed that the invention might usefully be practiced in other types of devices, including those employing dedicated digital circuitry, and perhaps even in devices comprised primarily of analog timing and control circuitry. As such, Figure 3 should be considered exemplary, rather than limiting with regard to the scope of applications of the present invention. While the invention is disclosed as embodied in a pacemaker, it is equally applicable to incorporation in a cardioverter, or combined cardioverter pacemaker, or even cardioverter defibrillator pacemaker. While the following discussion of Figure 3 assumes a single chamber ventricular pacing system, it is to be understood that the invention is applicable to 2-, 3- or 4-chamber systems. The primary elements of the apparatus illustrated in Figure 3 are microprocessor 100, read only memory 102, random access memory 104, a digital controller 106, input and output amplifiers 110 and 108 respectively, and a telemetry/programming unit 120. Read only memory 102 stores the basic programming for the device, including the primary instructions set defining the computations performed to derive the various timing intervals performed by the device. Random access memory 104 serves to store the values of variable control parameters, such as programmed pacing rate, pulse widths, pulse amplitudes, and so forth, which are programmed into the device by the physician. Random access memory also stores derived data, such as the cardiac signal data which is used to determine an LVD condition. Reading from random access memory 104 and read only memory 102 is controlled by RD-line 146. Writing to random access memory 104 is controlled by WR-Line 148. In response to a signal on RD-Line 146, the contents of random access memory 104 or read only memory 102 designated by the then present information on address bus 124 are placed on data bus 122. Similarly, in response to a signal on WR-line 148, information on data bus 122 is written into random access memory 104 at the address specified by the information on address bus 124. Controller 106 performs all of the basic timing and control functions of the device. Controller 106 includes at least one programmable timing counter, initiated on ventricular contractions, paced or sensed, for timing out intervals thereafter. It is also anticipated that the controller 106 would also perform the basic timing functions of the pacing, including 3- or 4-chamber pacing in response to LVD, in accordance with well known techniques. Controller 106 also triggers output pulses from output stage 108 as discussed below, and it generates interrupts on control bus 132 for cyclically waking microprocessor 100 from its sleep state to allow it to perform the required functions. Output circuit 108 is coupled to electrodes 138 and 140 which are employed in a unipolar configuration both for delivery of pacing pulses and for sensing of cardiac signals. Electrode 138 is typically located on the distal tip end of an endocardial lead and is typically placed in the apex of the right ventricle; electrode 140 is placed in the patient's right atrium; and electrode 142 represents the pacemaker housing, which may be used as the indifferent electrode for unipolar pacing and sensing operations. Output circuit 108 is controlled by controller 106 through bus 126 to determine the time, amplitude and pulse width of the pulse to be delivered and to determine which electrode pair will be employed to deliver the pulse. Sensing of QRS and T-waves is done by input amplifier circuitry, which receives sensed signals from electrodes 138, 142, or from electrodes 54, 55 for a bipolar system. Signals indicating the occurrences of natural ventricular contractions, and paced ventricular contractions as well as T-waves, are provided to the controller 106 via bus 128. Controller 106 passes data indicative of the occurrence of such ventricular signals to microprocessor 100 via control bus 132, for performance of all necessary calculations, and in particular for timing of the delivery of tachy-inducing pulses in the manner discussed below. External control of the implanted device is accomplished via telemetry/control block 120, which allows communication between the implanted device and an external programmer (not shown). Radio communication is typically employed via antenna 124. Appropriate telemetry/programming systems are disclosed in U.S. Pat. No. 4,401,120, issued to Hartlaub et al., U.S. Pat. No. 4,556,063, issued to Thompson et al., and U.S. Pat. No. 4,550,370, issued to Baker, all of which are incorporated herein by reference in their entireties. However, any conventional telemetry/programming circuitry is believed workable in the context of the present invention. Information entering the pacemaker from the programmer is passed to controller 106 via bus 130. Similarly, information from the pacemaker is provided to the telemetry block 120 via bus 130, for transmission to the external programmer. Also indicated as output from output block 108 are terminals 134 and 136, which may be used in connection with system ground for unilateral pacing or sensing of the left atrium and left ventricle. Again, if bipolar pacing and/or sensing is incorporated, additional electrodes are utilized as illustrated in Figure 2. Referring now to Figure 4, there is shown a flow diagram primarily of steps taken by a system in accordance with the method of this invention. It is to be understood that these steps are preferably carried out under the control of microprocessor 100, based on software conveniently stored in ROM 102 or RAM 104. In Figure 4, the first step, as illustrated at 40, is to obtain cardiac signals, which is suitably done each cardiac cycle, or on another convenient basis. In a simple version of the invention, this involves obtaining the QRS signal, or the time of a delivered stimulus; as well as obtaining the T-wave portion of the cardiac signal sensed in the right ventricle. Next, as shown at 42, the cardiac signals are processed, and the resulting data is stored. Thus, the QT time interval is determined and stored; the width or other morphological feature of the QRS portion is determined and stored; and/or the amplitude or other feature of the T-wave is determined and stored. At 43, it is determined whether it is time to analyze the stored data, in order to look for an indication of LVD. For example, the inquiry with respect to LVD may be made daily, or perhaps at longer predetermined intervals. Until this time has been reached, the program simply loops back and, during each cycle, repeats the steps of getting cardiac signals and processing them to obtain data for use in determining LVD. When and if the time period has run out, the program proceeds to step 44, and analyzes the data to determine whether LVD is indicated. This analysis may involve any number of different steps for operating on the data derived from the cardiac signals. Thus, changes in the correlation between QT and heart rate can be analyzed, to see whether the slope is substantially changed, by more than a predetermined amount; whether the low rate at rest has changed more than a predetermined number of bpm compared to a starting rate for the patient; whether the T-wave amplitude varies with rate in the normal rate or in an abnormal manner; whether the QRS width at a given rate has varied, thus indicating a cardiac conduction disorder; etc. If LVD is indicated at 44, the routine branches to 45, for carrying out an appropriate response. This response may be simple, such as setting a flag which can be interrogated by an external programmer for transmitting of data which indicates LVD. Other responses can be automatically undertaken aimed toward initiating treatment of the LVD. These responses can include administering a drug through device 65, in order to treat the condition. In another embodiment an indication of LVD leads to changing the rate response function. For a single sensor rate responsive pacemaker, this entails changing the rate response function so as to accommodate a different reaction to exercise. For a dual sensor rate response system, the response entails altering the blending of the relative influence each of the respective sensor signals. See, for example, U.S. Patent No. 5,065,759, incorporated herein by reference, which discloses a pacemaker where the relative influence of each of a QT signal and an activity signal is adjustable. Further, the response may entail initiation of 3- or 4-chamber pacing, which is directed primarily toward pacing the left ventricle of the heart so as to optimize left ventricular cardiac output. This response can be done automatically where this system incorporates an implanted pacemaker having capacity for providing 3- or 4-chamber pacing. In this situation, or the simpler situation mentioned above where the rate response function is changed, such change can be made by downloading new software for controlling pacemaker functionality into pacemaker memory. Referring now to Figure 5, there is shown a more detailed flow diagram of an embodiment where changes corresponding to QT interval are utilized for determining LVD. The procedure for Figure 5 is adapted for a QT rate responsive pacemaker, where pacing rate is determined as a function of sensed QT interval. At 46, QT is determined each cycle, and as illustrated at 47, pacing rate is set as a function of QT, i.e., R = f(QT). At 48, it is determined whether it is time to determine whether the rate function should be checked, e.g., is it nighttime and 24 has elapsed since the last check? If yes, at 49 the pacemaker goes through a routine for adjusting the function slope at LRL, as disclosed in incorporated reference U.S. Patent No. 5,065,759. At block 66, a similar adjustment of the slope at URL can likewise be made. At 68, under the control of the microprocessor, the correlation function R = f(QT) is adjusted to accommodate the changes in slope. At 70, the changes in slope, and/or the change in correlation function, are stored in memory. At 72, it is determined whether the pacemaker should examine the stored data in order to diagnose for an LVD condition. This examination may be made, for example, once a week or once every predetermined period of time. If such a diagnosis is to be made at 74, the data is analyzed to determine whether the changes in slope, or changes in correlation function indicate a trend or a history such as indicates onset of LVD. A simple set of criteria for making this determination can be used, e.g., slope changes exceeding a predetermined limit and in the direction of a smaller QT interval at rest. Referring now to Figure 6, there is shown a flow diagram for determining LVD by examining changes in the lowest heart rate (LR) during a 24 hour period, often the lowest natural rate the patient has during nighttime. At 80, LR is set equal to an initial value, LR 0 , which is a nominally high rate, i.e., above LRL. At 81, heart rate is determined, and at 82 the rate R is compared to LR. If R is less than LR at 83, LR is set equal to the new value R. At 84, it is determined whether a 24-hour period has passed. If no, the routine goes back to 81 and continues to analyze the rate data, on a cycle-by-cycle basis. When the 24-hour, or daily time period has elapsed, at 85 the value of LR for the last day is stored. This is conveniently done by updating a histogram in memory which provides easily stored data giving a profile of different values of LR. At 86, it is determined whether there should be a diagnosis of LVD, i.e., has enough time passed since the last diagnosis? If no, the routine branches back to 80, resets LR, and continues with the data collection process. If, at 86, it is determined that LVD is to be diagnosed, then at 87 the LR data is compared against predetermined criteria. For example, and referring Figure 1(C), if the data shows that the majority of LR readings has progressed from 60 to 80, or any other predetermined value relative to the starting point, this is taken as an indication of LVD, or at least a form of LVD requiring a response. Referring now to Figure 7, there is shown a flow diagram illustrating the primary steps of an algorithm for responding to a determination of LVD in a dual sensor pacemaker. Reference is again made to U.S. Patent No. 5,065,759, which illustrates a dual chamber pacemaker for controlling pacing rate as a function of QT interval, and an activity signal (ACT) derived from an activity sensor. In such a dual sensor pacemaker, the relative contribution of each of two or more rate- indicating parameters which are sensed by the pacemaker can be adjusted, or "blended." In the case of a combined QT-ACT pacemaker, it is known that the ACT sensor provides a faster but relatively less physiological response, whereas the QT interval provides a slower time response but a more physiological response to body changes. For a patient with LVD, it would be indicated to increase the relative influence or weight of the QT parameter, to provide a relatively slower response to changes in QT interval during exercise. As seen in Figure 7, at the start of this routine, it is determined whether there has been an indication of LVD, as shown at 90. If no, the routine skips to block 92. However, if there has been a determination of LVD, then at block 91, either one or both of weight factors a and b is adjusted to provide an overall rate response which is adapted to provide a more appropriate rate response for a patient with an LVD condition. At 92, the pacemaker gets the determination of the rate indicated by the QT which has just been determined, which rate is shown as R QT . At 93, the routine determines R ACT , which is the rate indicated by the activity sensor. At 94, the pacing rate R is determined as a function of aR QT + bR ACT , where b=a-1, and a and b thus designate the relative influences of the two sensors. At 95, the pacemaker proceeds to control rate by setting the pacing interval in accordance with the composite rate response function. It is seen that in this way, by adapting the blending of two or more sensors, a more appropriate response to an LVD condition can be obtained and carried out automatically. It is seen that this invention provides for determining a condition of LVD in a patient, by examination of cardiac signals. By comparing such cardiac signals to predetermined criteria, a conventional pacemaker, or one adapted to treat heart failure, can be provided with the capability of identifying the onset or progression of the LVD condition, and enabling an early treatment response. Upon a determination of LVD, the treatment response should be particularized for the individual patient, and can include changing the rate response algorithm, bi-ventricular pacing or other multi-chamber pacing, administration of drugs, etc.

Claims: An implantable system for pacing a patient's heart and for determining a condition of heart failure, comprising stimulus means (106, 108) for generating and delivering stimulus pulses to said patient's heart, heart signal monitoring means (110, 106) for monitoring patient heart signals and collecting heart signal data relating to said heart signals, process means (42) for processing said heart signal data to find changes over time in predetermined features of said heart signals, and indication means (72) for providing an indication of heart failure as a function of heart signal changes, characterized in that the system comprises QT means (46) for determining QT intervals and rate responsive means (47) for pacing said patient at a rate in accordance with an adjustable correlation function between QT interval and pacing rate, said rate responsive means comprises means (68) for automatically adjusting said correlation function in accordance with sensed variations of the patient relationship between QT and heart rate, said indication means comprises means (72) for determining a said heart failure condition as a function of said adjusted correlation function, said heart signal monitoring means comprises means (46) for determining the QT interval corresponding to patient heartbeats, said process means comprises means (49, 66) for determining variations of said QT interval with patient heart rate, and said indication means comprises means (72) for indicating an LVD condition as a function of said variation of QT interval with heart rate. The system as described in claim 1, characterized in that it further comprises response means (45) for automatically responding to a said heart failure indication by providing a treatment for said heart failure. The system as described in claim 2, characterized in that said response means comprises drug means (65) for delivering a drug to said patient. The system as described in claim 2, characterized in that said response means comprises pacing control means for controlling said stimulus means to deliver pacing pulses in accordance with a predetermined routine (94) adapted to a said heart failure condition. The system as described in claim 4, characterized in that said stimulus means comprises bi-ventricular means (54, 55; 60, 61) for delivering pacing pulses to at least said patient's left and right ventricles, and said control means comprises means for timing delivery of pacing pulses to said patient's left and right ventricles so as to improve cardiac output. The system as described in claim 1, characterized in that said process means comprises rate means (49, 66, 68, 70) for determining and storing data representative of variations in the patient's heart rate. The system as described in claim 6, characterized in that said rate means comprises means (81, 82, 83) for determining and storing data representative of the patient's lowest heart rate over a predetermined time duration. The system as described in claim 7, characterized in that said indication means comprises means (85, 87) for comparing said patient lowest heart rate with predetermined criteria, and for indicating onset of LVD as a function of said comparison. The system as described in claim 1, characterized in that said process means comprises means (42) for finding changes in morphology of a portion of patient heart signals, and said indication means comprises means (44) for determining when said changes indicate a progression of heart failure.

Inventors: BOUTE WILLEM, BOUTE, WILLEM
Applicants: VITATRON MEDICAL BV, VITATRON MEDICAL B.V.
Application year: 1998
Main classification: A61N1
IPC codes: A61N1