SELECTIVE cPLA2 INHIBITORS

Abstract: Selective inhibitors of the cPLA2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have general formula (i), where (R<1>), p, D, Y, Z, R<a>, R<b> and A are as defined in the specification.

Description: SELECTIVE cPLA z INHIBITORS BACKGROUND OF THE INVENTION Inflammatory diseases of the skin, such as psoriasis and atopic dermatitis, afflict greater than 5% of the population. Currently, the treatment of these disorders typically involves the use of topical steroids. However, these agents also have undesirable side effects such as skin atrophy which limit the duration of therapy. In addition, topical application of a drug is difficult for many patients where the affected area may be very large. Phospholipase A 2 (PLA 2 ) is the common name for phosphatide 2- acylhydrolase which catalyzes the hydrolysis of the sn-2-acyl ester bond of phosphoglycerides and results in production of lysophospholipids and free fatty acids. When the fatty acid is arachidonic acid, further action by cyclooxygenase and 5-lipoxygenase enzymes results in eicosanoid production, which is implicated in inflammation, and leukotrienes which are linked to asthma. Lysophophospholipid metabolism results in production of platelet activating factor and both lysophospholipids and platelet activating factor also play a role in inflammation. PLA 2 enzymes exist as secreted forms (MW ~ 12,000-15,000) and cytosolic forms (MW ~ 85,000). The cytosolic or cPLA 2 enzymes appear to play a key role in the pathway leading to the formation of platelet activating factor and the eicosanoids. L Inappropriate activation of the cytosolic PLA 2 enzymes, therefore, can result in a variety of chronic and acute conditions including asthma, cerebral ischemia (Clemens et al, Stroke. 1996, 27, 527-535), Alzheimer's Disease (Stephenson et al, Neurobiology of Stroke. 1996, 3, 51-63 and see also U.S. Patent 5,478,857), rheumatoid arthritis, neutrophil and platelet activation (Huang et al, Mediators of Inflammation. 1994, 3, 307-308), chronic skin inflammation and damage to the skin resulting from exposure to ultraviolet light (Gresham et al, American Tournal of Physiology. 1996, 270; Cell Physiology 39:0037-0050) and macrophage activation (Balsinde et al, Tournal of Biological Chemistry. 1996, 271, 6758- 6765). Selective inhibitors of the cPLA 2 enzymes may, therefore, be of use in controlling a wide variety of inflammatory diseases. The literature describes a significant number of compounds said to be phospholipase A 2 inhibitors, but few selective inhibitors for the cPLA 2 enzymes are available. The present inventors had as their goal the synthesis of novel compounds which would be selective and potent inhibitors of the cPLA 2 enzymes. As used herein, the term "selective inhibitors of the cPLA 2 enzymes" means that the inhibitors inhibit the cPLA 2 enzymes with a potency 20-fold or greater than they inhibit the lower molecular weight synovial PLA 2 enzymes. Biochemistry 32: 5935-5940, 1993, discloses a trifluoromethyl ketone analog of arachidonic acid having the formula as a selective inhibitor of cPLA2- Bioorganic Med. Chem. Lett. 5: 519-522, 1995, discloses selective CPLA2 inhibitors of the formula where R is either H or OH. Japanese published patent application JP09268153A (Derwent No. 97-554679/51) discloses cPLA 2 inhibitors of the formula RCOCF 3 where RCO is an acyl residue of an n-3 series highly unsaturated fatty acid. The compounds are said to be useful as antiinflammatory or antiallergic drugs. Published PCT Application WO 98/25893 discloses arylsulfonamide compounds of the general formula wherein T A represents a C 4 -C 10 alkyl group, an aryl group, an arylalkyl group, radicals selected from the group consisting of — CH=CH— B, -O— B,— S-B, and — NH — B, or radicals of formula CH 2 ~ X, wherein B represents a non-aromatic C 3 -C 8 carbocycle, a C 3 -C 8 alkyl group, a heterocycle or an arylalkyl group, each of which is optionally substituted with one or more members independently selected from the group consisting of a halogen atom, a C α -C 4 alkyl group, a C j -C 4 alkoxy group, cyano, nitro, a heterocycle, an aryl group and an aryloxy group, and X is a member selected from the group consisting of a halogen atom, — S— aryl,— S— heterocycle, and — P0 R 2 wherein each R is independently selected from the group consisting of a hydrogen atom and C j -C j alkyl; R 1 and R 2 each independently represent a hydrogen atom, a lower alkyl group, or a group represented by the formula: -(CH 2 ) q -A' wherein q is an integer of 2 to 4, and A' is a member selected from the group consisting of a hydroxyl group, a group represented by the formula: wherein R 5 and R 6 each independently represent a hydrogen atom, a lower alkyl group, or a group represented by the formula: ≤ wherein R 7 represents a hydrogen atom, a lower alkyl group, or a group represented by the formula: wherein s is an integer of 2 to 5; or R 1 and R 2 each independently represent an unsubstituted cycloalkyl group, or a cycloalkyl substituted with a lower alkyl or halogen or condensed with an aromatic ring, a bicycloalkyl, or tricycloalkyl, said bicycloalkyl or tricycloalkyl being an aliphatic saturated hydrocarbon group made of two or three rings, respectively, with at least two carbon atoms being common to each ring, or an azabicycloalkyl group which is a bicycloalkyl group as described above in which one carbon atom is replaced by a nitrogen atom or a group represented by the formula: _ / (CH 2 ) gs (OW wherein g and h are each an integer of 1 to 4, and B' stands for a lower alkyl group, an arylalkyl group, an arylalkyl group substituted by lower alkyl; halogen or a lower alkoxy group, or a pyridylalkyl group, or a pyridylalkyl group substituted with a lower alkyl group, a halogen or a lower alkoxy group; or R 1 and R 2 may be combined together to form a 6- or 7-membered ring which may contain a nitrogen or oxygen atom in addition to the nitrogen atom to which R 1 and R 2 are bonded, and said 6- or 7-membered ring may be substituted with a lower alkyl, arylalkyl, cycloalkylalkyl or heteroarylalkyl group; R 3 represents a hydrogen atom, a lower alkyl group, or a C 3 -C 8 cycloalkyl group; R 4 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group or a halogen atom; n is an integer of 1 to 4, provided that when n is 2, the two R 4 groups may form a cyclohexenyl or phenyl ring together with two adjacent carbon atoms constituting the benzene ring; and any pharmacologically acceptable salts thereof as inhibitors of phospholipase A 2 activity, particularly cPLA 2 . Drugs 1998, Vol. 1, No. 1, pp. 49-50 discloses cPLA 2 inhibitors of the type U.S. Patent 5,453,443 discloses a series of biaryl ketones which are reported to inhibit PLA 2 enzymes, but it is not indicated whether these compounds are selective for the cytosolic enzymes or even whether they inhibit the cytosolic enzymes. These compounds have the generic formula wherein: R 1 is selected from (a) hydrogen, (b) — Cι-6alkyl , and (c) — C 1-6 alkyl-phenyl; or wherein R 1 and R 5 are joined such that together with the carbon atoms to which they are attached there is formed a saturated or unsaturated carbon ring of 3, 4, 5, 6, 7 or 8 atoms; R 2 and R 3 are each independently selected from 2 (a) hydrogen, (b) — Ci-βalkyl , and (c) — C 1-6 alkyl-phenyl , or wherein two R 2 or two R 3 are joined such that together with the carbon atoms to which they are attached there is formed a saturated or unsaturated carbon ring of 3, 4, 5, 6, 7 or 8 atoms; R 5 is as defined above or is selected from (a) hydrogen (b) — Ci-βalkyl (c) — C 1-6 alkyl-phenyl C 1-6 alky 1 , (d) - OH , — O— C 1-6 alkyl< ©r (e) (f) — C 1-6 alkyl-phenyl C 1-6 alkyl ; R 6 is selected from (a) hydrogen (b) — Ci-βalkyl (c) — C^galkyl-phenyl, wherein the phenyl is optionally substituted with C x . 2 alkyl; (d) - CH , (f) —o— wherein the phenyl is optionally substituted with C^alkyl; or wherein two R 6 are joined to form o= or are joined together such that together with the carbon atom to which they are attached there is formed a saturated or unsaturated carbon ring of 3, 4, 5, 6, 7 or 8 atoms; R 8 , R 9 and R 14 are each independently selected from (a) H, (b) — Chalky! (c) halo (d) - CN (e) - OH (O ( ) - OCi^alkyl, — OCi^alkyl-phenyl (g) 00 ■ SR u S(0)R 11 (i) , or -.n (j) S W ; R 10 , R 15 , R 16 and R 17 are each independently selected from (a) hydrogen, (b) -C M alkyl, and (c) -C.. 6 alkyl-phenyl; R 11 is selected from (a) -C M alkyl, (b) -C 2.6 alkenyl, (c) -CF 3 , (d) -phenyl(R 12 ) 2 , or (e) -C 2.6 alkenyl-phenyl(R 12 ) 2 , R^ is (a) hydrogen, (b) - . 6 alkyl, (c) CI, F, I or Br; R 13 is perfluoro ^alkyl; A and B are each independently (a) covalent bond, (b) O, (c) s, ( ) S(O), or (e) S(0) 2 ; Q is selected from (a) - CH(OH)R 13 , • 2- (b) "COR 13 , (c) -C O R 16 , or (d) ~ C 1-4 alkylCOCOOR 17 ; X 1 is selected from (a) -°— , ( ) ~s — , (0 - S( ° ) - / (d) -S(θ)2— . Z is (a) H, or ( ) —phenyl (R 14 ) 3/ m is 0, 1, 2, 3 or 4; n is 2, 3, 4, 5, 6 or 7; and r and s are each independently 0, 1, 2, 3, 4, 5, 6, 7 or 8. SUMMARY OF THE INVENTION The present invention is directed to selective cytosolic PLA 2 inhibitor compounds of the formula wherein W is CH=CH, CH=N, O or S; R 1 is (Cι-C6)alkyl, (C2-C6)alkenyl, (C 2 -C 6 )alkynyl, (Cι-C6)alkoxy, O R 2 II 1 - (Ci-C6)alkylthio, halo, hydroxy, cyano, — c — N— R 3 in which R and R are each independently hydrogen or (Ci-C6)alkyl, -COO-(C 1 -C 6 )alkyl, CF 3 , (C 1 -C 6 )alkylphenyl, phenyl or phenyl substituted by one or more, 0 R 2 preferably 1-3, of (C C 6 )alkyl, -COO-(C C 6 )alkyl, — c — - R 3 in which R 2 and R 3 are as defined above, halo, hydroxy, -0-(C 1 -C 6 )alkyl, -S-(C 1 -C 6 )alkyl or (C 2 -C 6 )alkenyl; p is 0, 1 or 2; A is V-(R c ) n -; R c is a straight or branched chain alkyl group; n is 0 or an integer of from 1 to 6; H R a and R b when taken together form an oxo (=0) group, or R a and R b are each independently hydrogen or OH; V is O, -S-, -SO-, -S0 2 , -CONH or NHCO when n is an integer of from 1 to 6 or V is (C 2 -C 6 ) alkenyl or a bond when n is 0 or an integer of from 1 to 6; D is -(CH2)m or a bond linking the 1 ^ ring to Y; m is an integer of from 1 to 6; R 4 Y is -O-, -S-, -SO-, -Sθ2; - — or a bond; R 4 is as defined below for R 7 ; Z is: in which B is: NR 10 — c— o— c— — N-c— — N-c— — so 2 — or a bond; R 9 R 9 X is S or O; q is an integer from 1 to 6; R is hydrogen or ( -C^alkyl; .10 . R is hydrogen, CN, NO2, OH, -0-(Cι-C6)alkyl, (C1-C6) alkyl, phenyl or (Cl-C6)alkylphenyl; R and R 6 are each independently hydrogen or ( - g) alkyl; R 7 and R 8 are each independently; (a) hydrogen; (b) (Ci-Ci8)alkyl; (c) (Cl-Ciδ)alkyl substituted by one or more of (1) phenyl; (2) phenyl substituted by 1-5 fluoro, 1-3 (for each of the following phenyl substituents) halo (other than fluoro), 1-3 (Ci-C6)alkoxy, l-3(Ci-C6)alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Cι-C6)alkylthio, amino, 1-3 ( -C 6 ) alkylamino, di(Ci-C6)alkylamino, -CO2H, -COO- (Cι-C6)alkyl, -SO3H, -S02NHR 15 in which R 15 is hydrogen or (Ci-C6)alkyl, or — ° c— N R2 — R 3 in which R 2 and R 3 are as defined above; (3) heterocyclic selected from oxadiazolyl, isoxazolyl, oxazolyl, furyl and thiazolyl; (4) heterocyclic substituted by one or more of, preferably 1-3, phenyl, phenyl substituted by 1-3 (for each of the following) halo, (Cι-C 6 )alkoxy, ( -C alkyl, nitro, cyano, hydroxy, trifluoromethyl, (C,-C 6 ) alkylthio, amino, (C C 6 ) alkylamino, di(C C 6 ) alkylamino, C0 2 H, -COO-(C C 6 ) alkyl, -S0 3 H, S0 2 NHR 15 in which R 15 is hydrogen or (C r C 6 ) alkyl, or o R 2 - C- N-R 3 in which R 2 and R 3 are as defined above, ( -C alkyl or (C j -C 6 ) alkyl substituted by one or more, preferably 1-3, phenyl or heterocyclic groups, said phenyl or heterocyclic group being unsubstituted or substituted by 1-3 (for each of the following) halo, 1-3 (C,-C 6 ) alkoxy, 1-3 ( - ) alkyl, nitro, cyano, hydroxy, trifluoromethyl, ( -C 6 ) alkylthio, amino, 1-3 (C C 6 ) alkylamino, di(C C 6 ) alkylamino, COOH, -COO- (C r C 6 ) alkyl, -S0 3 H, -S0 2 NHR 15 in which R 15 is hydrogen or o R 2 (C C 6 ) alkyl, or - c- N- R 3 in which R 2 and R 3 are each independently hydrogen or (C,-C 6 ) alkyl, the heterocyclic radical being selected from imidazolyl, oxadiazolyl, isoxazolyl, pyrrolyl, pyrazolyl, oxazolyl, furyl, thianyl or thiazolyl; (5) carboxy or -COO-(C r C 6 ) alkyl; n (6) hydroxy, halo, -0-(C r C 6 ) alkyl or -S-(C r C 6 ) alkyl, with the proviso that the OH, ethers or thioethers cannot be on the carbon bearing the heteroatoms; (7) cyano; (8) halo, trifluoromethyl or trifluoroacetyl; (9) CH2 L-R 16 in which L is >17 R 17 I O II — N- — O— — S- • so- . - so, — N — C- N— , ■ c- I o17 — O- C— , — C- O— , — - C— — C- N— , R 7 R 17 or -0-SiR 16 R 18 R 19 or a bond in which R 16 and R 17 are each independently (Cι-Ciδ)alkyl or (C2-Ci8)alkenyl or (Cχ-Ci8)alkyl or (C2-Ci8)alkenyl substituted by one or more, preferably 1-3, phenyl or heterocyclic radicals, said phenyl or heterocyclic radicals being unsubstituted or substituted by 1-5 fluoro, 1-3 halo (other than fluoro), 1-3 (Ci-C6)alkoxy, l-3(Cι-C6)alkyl, nitro, cyano, hydroxy, 1-3 trifluoromethyl, 1-3 (Ci-C6)alkylthio, amino, l-3(Ci-C6)alkylamino, o R 2 1-3 di(Cι-C6)alkylamino, C0 2 H, 1-3 -COO(Cι-C6)alkyl, -C-N- R 3 Q r -S0 2 NHR 9 in which R 9 is hydrogen or (Cι-C6)alkyl and R 2 and R 3 are as defined above; »3 R 5 (b) (CH 2 ) q -C- R 6 N— B*— R' R β in which B is NR 10 — c- r — c— o— — c— N- R 9 , — c- NR 9 , — so 2 -, -PO(OR v ) 2 or a bond; providing that when B 1 is -PO(OR 9 ) 2 , then R 7 becomes R 9 , and when B 1 X is — c-o— ° r "S0 2 -, then R 7 cannot be hydrogen; X, q, R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are as defined in (a); in which q, R 5 and R 6 are as defined above; 18 19 11 7 8 R , R and R are as defined above for R and R except that they may 18 19 not be hydrogen, or R and R taken together with the nitrogen to which they are attached represent a 4, 5- or 6-membered heterocyclic ring and Y, R 7 and R 11 are as defined above, or R 18 , R 19 and R 11 taken together with the nitrogen to which they are attached represent pyridinium, said pyridinium group being unsubstituted or substituted by (Ci-Ci2)alkyl, (Ci-Ci2)alkoxy, amino, (Ci-Ci2)alkylamino, di fl O II O R 2 (Cι-Ci2)alkylamino, — c— o — (C r C 6 ) a lkyl, -S-(Cι-C 12) alkyl, — C-N- R 3 in 2 wwhhiicchh RR aanndd R are as defined above, phenyl or phenyl (Cl-Cιo)alkyl; d) in which R 13 is (Cι-Cιs)alkyl or (Cι-Cis)alkyl substituted by carboxy, 0 O R 2 -c-o-(c c 12 ) alkyl, - C- N- R 3 in which R 2 and R 3 are as defined above, hydroxy, -0-(C C 6 ) alkyl, -0-(C C 6 ) alkyl or -S-(C C 6 ) alkyl substituted by 1 or 2 phenyl or substituted phenyl groups, the substituents for the substituted phenyl groups being 1-5 fluoro or 1-3 (for each of the following phenyl substituents) halo (other than fluoro), (C C 6 ) alkoxy, (C x -C 6 ) alkyl, nitro, cyano, hydroxy, trifluoromethyl, ( - ) alkylthio, amino, ( - ) alkylamino, di(C,-C 6 ) alkylamino, C0 2 H, COO-(C,-C 6 ) alkyl, S0 3 H, o R 2 S0 2 NHR 15 in which R 15 is hydrogen or (C r C 6 ) alkyl or - c- N- R 3 in which R 2 and R 3 are as defined above; r is 0 or an integer of from 1 to 3; R 7 is as defined above; O I I o M 0 | R I 2 M is -(CH2-) m T where T is — C— , — C-O , -c-N— , i n which R 2 is as defined above, -S0 2 - or a bond when MR 7 is on nitrogen and providing O that when T is — G— or -SO- or -S0 2 -, then R 7 cannot be hydrogen, and T 26 O O ,14 II is — C— , — C-O— , -O-, -S-, -SO-, -Sθ2-, -N— or a bond when MR 7 is on a carbon atom of the heterocyclic ring; R 14 is hydrogen or (Cl-Cβ)alkyl; m is 0 or an integer of 1-6; R b e) -(CH 2 ^ -R 6 Q R 7 wherein Q is -O-, -S-, -SO- or -SO-.-, and q, R 5 , R 6 and R 7 are as defined above, providing that when Q is -SO- or -S0 2 -, R 7 cannot be hydrogen; f) R 7 wherein R 7 is defined above, providing that when Y is -SO- or -S0 2 -, R 7 cannot be hydrogen; and R 18 and R 19 are phenyl or phenyl substituted by 1-3 halo, (C,-C 6 ) alkoxy, (C x -C 6 ) alkyl, nitro, cyano, hydroxy, trifluoromethyl, ( -C 6 ) alkylthio, amino, (C C 6 ) alkylamino, di(C j -C 6 ) alkylamino, C0 2 H, -COO-(C C 6 ) alkyl, -S0 3 H, S0 2 NHR 15 in which R 15 is o R 2 hydrogen or ( -C alkyl, or - c- N- R 3 in which R 2 and R 3 are as defined above; or pharmaceutically acceptable salts, solvates or prodrugs thereof. Also provided by this invention are methods for inhibiting cytosolic PLA 2 in a mammal in need thereof which comprises administering to said mammal a therapeutically effective amount of a compound of formula I and methods for using the compounds of formula I to treat various diseases characterized by inappropriate activation of the cytosolic PLA 2 enzymes such as asthma, allergic rhinitis, cerebral ischemia, Alzheimer's Disease, rheumatoid arthritis, acute pancreatitis, inflammatory bowel disease, psoriasis, gout, neutrophil and platelet activation, chronic skin inflammation, shock, trauma-induced inflammation such as spinal cord injury, damage to the skin resulting from UV light or burns and macrophage activation. In further aspects, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of formula I and a pharmaceutically acceptable carrier and processes for preparing the compounds of formula I. DETAILED DESCRIPTION The object of this invention was to discover a selective cPLA 2 inhibitor which is active, both topically and orally, in treating inflammary disease of the skin and other tissues as well as other chronic and acute conditions which have been linked to inappropriate activation of the cPLA 2 enzymes. Preferably such compound would also be devoid of undesirable lipid-perturbing activities associated with skin irritation. The above-mentioned objectives have been met by the compounds of formula I described above. In the present application the numbers in the subscript after the symbol "C" define the number of carbon atoms a particular group can contain. For example, C M8 alkyl refers to straight and branched chain alkyl groups with 1 to 18 carbon atoms. Similarly, C 2 -C 18 alkenyl refers to a straight or branched unsaturated hydrocarbon group containing from 2 to 18 carbon atoms and at least one carbon-carbon double bond. Likewise, C 2 -C 18 alkynyl refers to a straight or branched unsaturated hydrocarbon group containing from 2 to 18 carbon atoms and at least one carbon-carbon triple bond. The term "halogen" or "halo" as used herein refers to fluorine, chlorine, bromine or iodine. Aryl as used herein refers to a C 6 monocyclic aromatic ring system or a C 9 or C 10 bicyclic carbocyclic ring system having one or two aromatic rings such as phenyl or naphthyl. Unless otherwise indicated, "substituted aryl" refers to aryl groups substituted with one or more (preferably from 1 to 3) substituents independently selected from (C j -C 6 )alkyl, haloalkyl, ( -C alkoxy, (C j -C alkoxy-carbonyl, ( -C alkanoyl, hydroxy, halo, mercapto, nitro, amino, cyano, ( -C alkylamino, di(C C 6 )alkylamino, carboxy, aryl, aryl (C 1 -C 6 )alkyl, aryl (C 1 -C 6 )alkoxy, heterocyclic, heterocyclic ( -C alkyl and the like. The term "heterocyclic" as used herein refers to a 4-, 5- or 6- membered ring containing one, two or three heteroatoms selected from N, O and S. The 5-membered ring has 0-2 double bonds and the 6- membered ring has 0-3 double bonds. The nitrogen heteroatoms can be optionally quaternized or N-oxidized. The sulfur heteroatoms can be optionally S-oxidized. The term "heterocyclic" also includes bicyclic groups in which any of the above heterocyclic rings is fused to a benzene ring or a cyclohexane ring or another heterocyclic ring. Heterocyclics include: pyrrolyl, pyrrolinyl, pyrrolidinyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, imidazolyl, imidazolidinyl, pyridyl, piperidyl, pyrazinyl, piperazinyl, pyrimidinyl, pyridazinyl, oxazolyl, oxazolinyl, oxazolidinyl, isoxazolyl, isoxazolinyl, isoxazolidinyl, morpholinyl, thiazolyl, thiazolidinyl, isothiazolyl, isothiazolidinyl, indolyl, quinolinyl, benzimidazolyl, benzothiazolyl, benzoxazolyl, benzofuranyl, furyl, dihydrofuranyl, tetrahydrofuranyl, pyranyl, dihydropyranyl, dioxolanyl, thienyl, benzothienyl and diaxanyl. Some of the compounds described herein contain one or more asymmetric centers and may thus give rise to diastereomers and optical isomers. The present invention is meant to include such possible diastereomers as well as their racemic and resolved, enantiomerically pure forms, and pharmaceutically acceptable salts thereof. As mentioned above the invention also includes pharmaceutically acceptable salts of the compounds of formula I. A compound of the invention can possess a sufficiently acidic, a sufficiently basic, or both functional groups. Accordingly, a compound may react with any of a number of inorganic bases, and organic and inorganic acids, to form a pharmaceutically acceptable salt. The term "pharmaceutically acceptable salt" as used herein refers to salts of the compounds of formula I which are substantially non-toxic to living organisms. Typical pharmaceutically acceptable salts include those salts prepared by reaction of the compounds of the present invention with a pharmaceutically acceptable mineral or organic acid or an inorganic base. Such salts are known as acid addition and base addition salts. Acids commonly employed to form acid addition salts are inorganic acids such as hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, phosphoric acid, and the like, and organic acids such as p- toluenesulfonic, methanesulfonic acid, oxalic acid, p- bromophenylsulfonic acid, carbonic acid, succinic acid, citric acid, benzoic acid, acetic acid, and the like. Examples of such pharmaceutically acceptable salts are the sulfate, pyrosulfate, bisulfate, sulfite, bisulfite, phosphate, monohydrogen phosphate, dihydrogen phosphate, metaphosphate, pyrophosphate, chloride, bromide, iodide, acetate, propionate, decanoate, caprylate, acrylate, formate, isobutyrate, caproate, heptanoate, propionate, oxalate, malonate, succinate, suberate, sebacate, fumarate, maleate, butyne-l,4-dioate, hexyne-l,6-dioate, benzoate, chlorobenzoate, methylbenzoate, dinitrobenzoate, hydroxybenzoate, methoxybenzoate, phthalate, sulfonate, xylene-sulfonate, phenylacetate, phenylpropionate, phenylbutyrate, citrate, lactate, γ-hydroxybutyrate, glycolate, tartrate, methanesulfonate, propanesulfonate, naphthalene-1- sulfonate, napthalene-2-sulfonate, mandelate and the like. Preferred pharmaceutically acceptable acid addition salts are those formed with mineral acids such as hydrochloric acid and hydrobromic acid, and those formed with organic acids such as maleic acid and methanesulfonic acid. Base addition salts include those derived from inorganic bases, such as ammonium or alkali or alkaline earth metal hydroxides, carbonates, bicarbonates, and the like. Such bases useful in preparing the salts of this invention thus include sodium hydroxide, potassium hydroxide, ammonium hydroxide, potassium carbonate, sodium carbonate, sodium bicarbonate, potassium bicarbonate, calcium hydroxide, calcium carbonate, and the like. Suitable organic bases include trialkylamines such as triethylamine, procaine, dibenzylamine, N-benzyl-β-phenethylamine, 1- ephenamine, N,N'-dibenzylethylene-diamine, dehydroabietylamine, N- ethylpiperidine, benzylamine, dicyclohexylamine, or the like pharmaceutically acceptable amines. The potassium and sodium salt forms are particularly preferred. It should be recognized that the particular counterion forming a part of any salt of this invention is usually not of a critical nature, so long as the salt as a whole is pharmacologically acceptable and as long as the counterion does not contribute undesired qualities to the salt as a whole. The present invention also includes solvated forms of the compounds of formula I, particularly hydrates, in which the trifluoromethyl ketone group exists as a mixture of ketonic I and hydrated forms π and are each independently interconvertible and pharmacologically active. I π The present invention also includes prodrug forms of the compounds of formula I or II above such as trifluoromethylketone enol ester derivatives, enol phosphate derivatives, cyclic or acylic unsubstituted or substituted 0,0-ketals, 0,S-ketals, 0,N-ketals or S,N- ketals such as cyclic cysteamyl derivatives, cyclic glycolates, thioglycolates, glyoxylates or oxalates, and the like. It also includes trifluoromethylalcohols obtained by chemical reduction of trifluoromethylketones. Such forms are physiologically hydrolyzable groups which are converted in vivo to a pharmacologically active compound of formula I or II, or a crystalline form of such compounds, see scheme below. R = alkyl or x = o,s substituted alkyl NH, O, S Ior fl R = alkyl or substituted alkyl R \ / R Preferred compounds of formula I are those where the -A-CCF 3 substituent is linked to the phenyl ring at the para or meta position, most preferably at the para position. 11 Preferred embodiments of the compounds of general formula I include (a) compounds of formula I wherein W is CH=CH, D is a bond linking Y to the ring and Y is -O-; (b) compounds of (a) immediately above wherein R 1 is benzyl, A is V-(CH 2 ) n -, V is (C 2 -C 6 ) alkenyl or a bond, p is 0, 1 or 2, and n is 0 or an integer of from 1 to 6; and (c) compounds of (b) immediately above wherein A is -(CH 2 ) n , n is 0 or an integer of from 1 to 6, and the group -(CH 2 ) n COCF 3 is in the meta or para position of the phenyl ring. Another preferred embodiment comprises a compound of the formula wherein R 1 is benzyl; p is 0, 1 or 2; A is V-(CH 2 ) n -; V is (C 2 -C 6 ) alkenyl or a bond; n is 0 or an integer of from 1 to 6; R a and R b are as defined above and Z is 2? in which B is X X II II NR 10 -c— ,o- c— , -N-C— , - N- c so 2 — or a bond; h « X is S or O; q is an integer of from 1 to 6; R 9 is hydrogen or ( -C alkyl; R 10 is hydrogen, CN, N0 2 , OH, -0-(C r C 6 ) alkyl, (C,-C 6 ) alkyl, phenyl or (C r C 6 ) alkylphenyl; R 5 and R 6 are each independently hydrogen or ( - ) alkyl; and R 7 and R 8 are each independently a) hydrogen; b ) ( -C 18 ) alkyl; c) (C α -C 18 ) alkyl substituted by one or more of, preferably 1-3, (1) phenyl; (2) phenyl substituted by 1-5 fluoro, 1-3 halo (other than fluoro), 1-3 (C j - ) alkoxy, 1-3 ( - ) alkyl, nitro, cyano, hydroxy, 2°! trifluoromethyl, (C C 6 ) alkylthio, amino, 1-3 (C C 6 ) alkylamino, di(C,-C 6 ) alkylamino, -C0 2 H, -COO-(C C 6 ) alkyl; -S0 3 H, - S0 2 NHR 15 in which R 15 is hydrogen or (C r C 6 ) alkyl, or O R 2 - C- N -R 3 in which R 2 and R 3 are each independently hydrogen or ( -C 6 ) alkyl; (3) heterocyclic selected from oxadiazolyl, isoxazolyl, oxazolyl, furyl and thiazolyl; (4) heterocyclic substituted by one or more of, preferably 1-3, phenyl, phenyl substituted by 1-3 halo, (Ci-C6)alkoxy, (Cl-C6)alkyl, nitro, cyano, hydroxy, trifluoromethyl, (C C 6 ) alkylthio, amino, ( - ) alkylamino, d^ - ) alkylamino, C0 2 H, -COO-(C r C 6 ) alkyl, -S0 3 H, S0 2 NHR 15 in which R 15 is hydrogen or o R 2 (C C 6 ) alkyl, or - c- N- R 3 in which R 2 and R 3 are as defined above, ( - ) alkyl or ( - ) alkyl substituted by one or more, preferably 1-3, phenyl or heterocyclic groups, said phenyl or heterocyclic group being unsubstituted or substituted by 1-3 halo, 1-3 ( - ) alkoxy, 1-3 (C C 6 ) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (C 1 -C 6 ) alkylthio, amino, 1-3 ( - ) alkylamino, di(C j -C 6 ) alkylamino, COOH, -COO-(C r C 6 ) alkyl, -S0 3 H, -S0 2 NHR 15 in which R 15 is O R 2 hydrogen or (C C 6 ) alkyl, or - c- N- R 3 in which R 2 and R 3 are each independently hydrogen or ( -C 6 ) alkyl, the heterocyclic radical being selected from imidazolyl, oxadiazolyl, isoxazolyl, pyrrolyl, pyrazolyl, oxazolyl, furyl, thianyl or thiazolyl; (5) carboxy or -COO-(Cj . -C 6 ) alkyl; (6) hydroxy, halo, -0-(C--C 6 ) alkyl or -S(C C 6 ) alkyl, with the proviso that the OH, ethers or thioethers cannot be on the carbon bearing the heteroatoms; So (7) cyano; (8) halogen, trifluoromethyl or trifluoroacetyl; or (9) CH2 L-R 16 in which L is R 17 R 17 C O II — N — O— — S— -SO- , -S0 2 - , —N-C—, —C-N—, ■ c— . 3 17 0 II 0 II s II s II — 0-C— , > — C-0— ,' — N|-C— I —C-N ,—, R 17 R 17 or -0-SiR 16 R 18 R 19 or a bond in which R 16 and R 17 are each independently (Cχ-Cχs)alkyl or (C2-Ci8)alkenyl or (Cχ-Cιs)alkyl or (C2-Cχδ)alkenyl substituted by one or more, preferably 1-3, phenyl or heterocyclic radicals, said phenyl or heterocyclic radicals being unsubstituted or substituted by 1-5 fluoro, 1-3 halo (other than fluoro), 1-3 (Cχ-C6)alkoxy, l-3(Cχ-C6)alkyl, nitro, cyano, hydroxy, 1-3 trifluoromethyl, 1-3 (Cι-C6)alkylthio, amino, 1-3 (Cχ-C6)alkylamino,l-3 di(Cχ-C6)alkylamino, C0 2 H, 1-3 o R 2 -COO(Ci-C6)alkyl, -c-N- R 3 or -S0 2 NHR 9 in which R 9 is hydrogen or (Ci-C6)alkyl and R 2 and R 3 are as defined above; and R 18 and R 19 are phenyl or phenyl substituted by 1-3 halo, ( -C 6 ) alkoxy, ( - ) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (C j -C 6 ) alkylthio, amino, ( - ) alkylamino, di( -C 6 ) alkylamino, C0 2 H, -COO- ( - ) alkyl, -S0 3 H, S0 2 NHR 15 in which R 15 is hydrogen or (C C 6 ) 0 R 2 alkyl, or - c- N- R 3 in which R 2 and R 3 are as defined above; or pharmaceutically acceptable salts, solvates or prodrugs thereof. in which B 1 is X NR 10 II — c- r — c— o— — c— N- R 9 , — c- NR 9 , — so 2 -, -PO(OR 2 or a bond; providing that when B 1 is -PO(OR 9 ) 2 , then R 7 becomes R 9 , and when B 1 is X — c-o— or -S0 2 -, then R 7 cannot be hydrogen; and X, q, R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are as defined above in (a); in which R 13 is (Cχ-Cχ8)alkyl or (Cχ-Cιs)alkyl substituted by carboxy, o II O II R I 2 _ _ -c-o-(c r c 12 ) alkyl, - C- N-R 3 in which R and R are as defined above, hydroxy, -0-(C r C 6 ) alkyl, -0-(C C 6 ) alkyl or -S-(C C 6 ) alkyl substituted by 1 or 2 phenyl or substituted phenyl groups, the substituents for the substituted phenyl groups being 1-5 fluoro or 1-3 halo (other than fluoro), (C α -C 6 ) alkoxy, ( - ) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (C j -C 6 ) alkylthio, amino, (C C 6 ) alkylamino, di(C α -C 6 ) alkylamino, C0 2 H, COO- (C C 6 ) alkyl, S0 3 H, S0 2 NHR 15 in which R 15 is hydrogen or (C C 6 ) alkyl or O R 2 - c- N- R 3 in which R 2 and R 3 are as defined above; r is 0 or an integer of from 1 to 3; R 7 is as defined above; O o o R 2 M is -(CH2-)mT where T is — C— , - C- O , - c - N— , m which R 2 is as defined above, -S0 2 - or a bond when MR 7 is on nitrogen and providing O II that when T is — e— or -SO- or -S0 2 -, then R cannot be hydrogen, and T O O R 14 is -C— , -C-O— , -O-, -S-, -SO-, -Sθ2-, -N— or a bond when MR 7 is on a carbon atom of the heterocyclic ring; R is hydrogen or (Cl-C6)alkyl; m is 0 or an integer of 1-6; (d) wherein Q is -O-, -S-, -SO-, or -S0 2 - and q, R 5 , R 6 and R 7 are as defined above, providing that when Q is -SO- or -S0 2 -, R 7 cannot be hydrogen; or (e) R 7 where R 7 is as defined above, providing that when Y is -SO- or -S0 2 -, R 7 cannot be hydrogen; or a pharmaceutically acceptable salt, solvate or prodrug thereof. Another preferred embodiment comprises a compound of the formula (CH 2 ) n COCF 3 wherein n is 0 or an integer of from 1 to 6, the substituent -(CH 2 ) n COCF 3 is in the meta or para position of the phenyl ring and Z is R 5 (CH 2 ^C-R 6 B-N-R 7 R 8 X in which B is — Q — or a bond; X is S or O; q is an integer of from 1 to 6; and R 5 , R 6 , R 7 and R 8 are as defined above; or a pharmaceutically acceptable salt, hydrate or prodrug thereof. Another preferred embodiment comprises a compound of the formula o-z (CH 2 ) n C0CF 3 in which R 1 is benzyl; p is 0, 1 or 2; n is 0 or an integer of from 1 to 6; the substituent -(CH 2 ) n COCF 3 is in the meta or para position of the phenyl ring; and Z is il in which B 1 is 10 X X X NR — c- -C-0-, -c- N- R 9 , - c - NR 9 , — so 2 — or a bond; q is an integer of from 1 to 6; X is S or O; and R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are as defined above; or a pharmaceutically acceptable salt, solvate or prodrug thereof. Within this embodiment, it is preferred that the substituent -(CH 2 ) n COCF 3 is in the para position of the phenyl ring, R 5 and R 6 are both hydrogen, q is 1, 2 or 3, n is 2 or 3, B 1 is X X X N R1 ° -c— , - C - 0 -, -C-N-R 9 , -C-NR 9 , or — S0 2 -, and R 7 and R 8 are each independently hydrogen or ( - g) alkyl. Especially preferred are compounds where q is 1, n is 2 and B 1 is X II X x 'I Q — C — , -C-0-, -C-N-R 9 or — S0 2 — . Another preferred embodiment comprises a compound of the formula 3i wherein n is 0 or an integer of from 1 to 6; the substituent -(CH 2 ) n COCF 3 is in the meta or para position of the phenyl ring; and Z is in which R 13 , r, M and R 7 are as defined above, or a pharmaceutically acceptable salt, solvate or prodrug thereof. Another preferred embodiment comprises a compound of the formula in which n is 0 or an integer of from 1 to 6, the substituent -(CH 2 ) n COCF 3 is in the meta or para position of the phenyl ring; and Z is wherein q is an integer of from 1 to 6; R 5 and R 6 are each independently hydrogen or (Cχ-Cχ8)alkyl; and Q and R 7 are as defined above, or a pharmaceutically acceptable salt, solvate or prodrug thereof. Another preferred embodiment comprises a compound of the formula in which n is 0 or an integer of from 1 to 6; the substituent -(CH 2 ) n COCF 3 is in the meta or para position of the phenyl ring; and Z is (a) hydrogen; (b) (Ci-C 18 )alkyl; (c) (Cχ-Cχ8)alkyl substituted by one or more, preferably 1-3, of (1) phenyl; (2) phenyl substituted by 1-5 fluoro, 1-3 halo (other than fluoro), l-3(Cχ-C6)alkoxy, l-3(Cι-C6)alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Ci-C6)alkylthio, amino, 1-3 ( - ) alkylamino, di(Ci-C6)alkylamino, -CO2H, -COO- 3? (Cι-C6)alkyl, -SO3H, -S02NHR 15 in which R 15 is hydrogen O R 2 2 3 or (Ci-C6)alkyl, or — c— N— R 3 in which R and R are each independently hydrogen or ( - ) alkyl; (3) heterocyclic selected from oxadiazolyl, isoxazolyl, oxazolyl, furyl and thiazolyl; (4) heterocyclic substituted by one or more, preferably 1-3, of phenyl, phenyl substituted by 1-3 halo, (Cχ-C6)alkoxy, (C j -C 6 )alkyl, nitro, cyano, hydroxy, trifluoromethyl, (C 1 -C 6 ) alkylthio, amino, (C C 6 ) alkylamino, di(C 1 -C 6 ) alkylamino, C0 2 H, -COO-(C,-C 6 ) alkyl, -S0 3 H, S0 2 NHR 15 in O R 2 which R 15 is hydrogen or ( - ) alkyl, or - c- N- R 3 in which R 2 and R 3 are as defined above, ( -C 6 ) alkyl or ( -C 6 ) alkyl substituted by one or more, preferably 1-3, phenyl or heterocyclic groups, said phenyl or heterocyclic group being unsubstituted or substituted by 1-3 halo, 1-3 (C C 6 ) alkoxy, 1-3 ( - ) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (C,-C 6 ) alkylthio, amino, 1-3 (C 1 -C 6 ) alkylamino, di( -C 6 ) alkylamino, COOH, -COO-(C C 6 ) alkyl, -S0 3 H, -S0 2 NHR 15 in which R 15 is hydrogen or (C r C 6 ) alkyl, 0 R 2 or -c- N- R 3 in which R 2 and R 3 are each independently hydrogen or ( -C 6 ) alkyl, the heterocyclic radical being selected from imidazolyl, oxadiazolyl, isoxazolyl, pyrrolyl, pyrazolyl, oxazolyl, furyl, thianyl or thiazolyl; (5) carboxy or -COO-(C C 6 ) alkyl; (6) hydroxy, halo, -O^ - ) alkyl or -S-(C 1 -C 6 ) alkyl, with the proviso that the OH, ethers or thioethers cannot be on the carbon bearing the heteroatoms; (7) cyano; (8) halogen, trifluoromethyl or trifluoroacetyl; (9) CH2 L-R 16 in which L is >17 R 17 0 O — N- -O — — s— - so- S0 2 - , — N- C- - C- N- , - C- , I R 17 0- C— I — C- O— ,> — i - C— > — C- N I — , R 17 R 17 or -0-SiR 16 R 18 R 19 or a bond in which R 16 and R 17 are each independently (Ci-Cχs)alkyl or (C2-Cχs)alkenyl or (Cχ-Cis)alkyl or (C2-Cχδ)alkenyl substituted by one or more, preferably 1-3, phenyl or heterocyclic radicals, said phenyl or heterocyclic radicals being unsubstituted or substituted by 1-5 fluoro, 1-3 halo (other than fluoro), 1-3 (Cχ-C6)alkoxy, l-3(Cχ-C6)alkyl, nitro, cyano, hydroxy, 1-3 trifluoromethyl, 1-3 (Cχ-C6)alkylthio, amino, l-3(Cι-C6)alkylamino, o R 2 1-3 di(Cι-C6)alkylamino, C0 2 H, 1-3 -COO(Cι-C6)alkyl, —c-N- R 3 or -S0 2 NHR 9 in which R 9 is hydrogen or (Cχ-C6)alkyl and R 2 and R 3 are as defined above; and R 18 and R 19 are phenyl or phenyl substituted by 1-3 halo, (C α -C 6 ) alkoxy, ( -C 6 ) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (C C 6 ) alkylthio, amino, (C C 6 ) alkylamino, di(C 1 -C 6 ) alkylamino, C0 2 H, -COO-(C r C 6 ) alkyl, -S0 3 H, S0 2 NHR 15 in which R 15 is o R 2 hydrogen or (C C 6 ) alkyl, or - c- N- R 3 in which R 2 and R 3 are as defined above; or pharmaceutically acceptable salts, solvates or prodrugs thereof. Another preferred embodiment comprises a compound of the formula in which n is 0, 1 or 2; or a pharmaceutically acceptable salt or prodrug thereof. Preferred embodiments comprise a compound selected from those of the following wherein (a) R 25 is -(CH 2 ) 3 CH ' ■ v (b) R 25 is -(CH 2 ) 3 C0 2 C 2 H 5 ; (c) R^ is -(CH 2 ) 3 CONHC 2 H 5 ; (d) R 25 is -COCF 3 ; (e) R >2 2 5 5 i • s -COC 6 H 5 ; and (f) R 25 is -PO(OC 2 H 5 ) 2 ; or a pharmaceutically acceptable salt thereof. Still other preferred embodiments comprise a compound of the formula wherein (a) R 20 is -CO(CH 2 ) 10 CH 3 ; (b) R 20 is -COCH(p-chlorophenyl) 2 ; and (c) R 20 is -S0 2 (CH 2 ) n CH 3 ; or a pharmaceutically acceptable salt thereof. Still other preferred embodiments comprise a compound selected from those of the following wherein (a) X" and X 1 " are CI; (b) X" and X" 1 are F; (c) X" and X 1 " are OCH 3 ; and (c) X" is CI and X 1 " is OCH 3 ; or a pharmaceutically acceptable salt thereof. Another preferred embodiment comprises a compound of the formula wherein (a) n is 1 and R 21 is OCH 3' (b) n is 1 and R 21 is CI; (c) n is 2 and R 21 is OCH 3 ; and (d) n is 1-4 and R 21 is OCH 3 or CI; or a pharmaceutically acceptable salt thereof. Another preferred embodiment comprises a compound of the formula wherein M (a) R 22 is hydrogen and R 23 is CI; or (b) R 22 is -C0 2 CH 3 and R 23 is -OCH 3 ; or a pharmaceutically acceptable salt thereof. Another preferred embodiment comprises a compound of the formula wherein R 24 is CI or -OCH 3 ; or a pharmaceutically acceptable salt thereof. Another preferred embodiment comprises a compound of the formula MM wherein (a) R 26 and R 27 are both CH 3 or (C C 6 )alkyl-CF 3 ; (b) R 26 and R 27 are both CI, F or Br; (c) R 26 and R 27 are both OCH 3 or SCH 3 ; (d) R 26 is CI and R 27 is OCH 3 ; or (e) R 26 and R 2 are both -COO-(C r C 6 )alkyl; or a pharmaceutically acceptable salt thereof. Still other preferred embodiments comprise a compound selected from those of the following wherein (a) n is 0; M (b) n = 1; and (c) n = 2; or a pharmaceutically acceptable salt thereof. Still other preferred embodiments comprise a compound selected from those of the formula wherein (a) n = 0; (b) n = 1; and (c) n = 2; or a pharmaceutically acceptable salt thereof. Some specific preferred embodiments of the present invention are: R 25 = (CH 2 )3CH 3 R 20 = CO(CH2)ιoCH 3 R 25 = (CH2) 3 C0 2 Et R20 _ C0CH(PhpCI) 2 R 25 = (CH2) 3 CONHEt R 20 = S0 2 (CH2)nCH3 R 25 - COCF3 R 25 = COC 6 H 5 R 25 = PO(OEt) 2 X" and X"' are CI n = 1, R 21 1 = 0CH3 X" and X"' are F n = 1 R 2 =CI X" and X'" are OCH 3 n - 2 , R 21 = OCH3 3 2 X"isClandX m is OCH 3 n = 1-4, R^1 = OCH 3 , CI R 22 =H, R 23 = CI R 24 =CI R 22 = C0 CH 3 , R 23 = OMe R 4 =OCH 3 and Hi wherein (a) R 26 and R 27 are both CH 3 or -(C r C 6 )alkyl-CF 3 ; (b) R 26 and R 27 are both CI, F or Br; (c) R 26 and R 27 are both OCH 3 or SCH (d) R 26 is CI and R 27 is OCH 3 ; or (e) R 26 and R 27 are both -COO-(C r C 6 )alkyl. Especially preferred embodiments of the present invention include: ^ X = 0 X = C The compounds of the present invention can be prepared by various methods which are known in the art. Illustrative methods of preparation are provided in the reaction schemes which follow and in the Examples. S Scheme 1 2) TFAA-Pyridine 5 S J»ι Scheme 2 (CH 2 ) n R 2 (CH 2 ) n R 2 τ~ Scheme 3 1 1 D2 / R (CH 2 ) m COCF 3 (CH 2 ) m COCF 3 13 14 (CH 2 ) m COCF 3 15 S> Scheme 4 dichlo 20 21 nR z 22 22 SH Scheme 5 25 Scheme 6 s ' Scheme 7 28 29 30 31 32 TFA 33a 33b SI Scheme 8 BrCH 2 C0 2 tBu BrCH 2 Cθ2tBu acetone acetone potassium carbonate potassium carbonate (or R 2 COCI) 3Z 38 39 tt Scheme 8 (cont.) 36 40 TFA dichloromethane 41 39 < Scheme 9 RSH BrCH 2 CH 2 OH ► RSCH 2 CH 2 OH DMF 4 , potassium carbonate — 42 44 mCPBA . Nal0 4 dichloromethane , methanol 47 48 R = C Cι 8 alkyl = (C Cβ) alkyl X(C β) mono or bis aryl or mono or bis heterocycles X = N-R 1 0, S, SO, S0 2 Method of Preparation Preparation of compounds of formula I may be accomplished via one or more of the synthetic schemes which are described below. Scheme 1 Scheme I shows a method of preparing compounds of general structure 6. Reaction of a phenol 2 bearing a protected carboxylate group with an alcohol 3, triphenylphosphine and diethyl azodicarboxylate or diisopropyl azodicarboxylate under Mitsunobu conditions (O. Mitsunobu, Synthesis, 1, 1981) in a solvent such as tetrahydrofuran or benzene gave the ether 4. Alternatively, the phenol 2 can be alkylated with a substituted alkyl halide (RX) and a base such as potassium carbonate in a solvent such as acetonitrile or dimethylformamide to give the ether 4. The ester group of 4 is then saponified to the acid 5 by treatment with a base such as sodium hydroxide or potassium hydroxide in a solvent such as aqueous ethanol followed by neutralization with a diluted acid. The acid 5 is then treated with oxalyl chloride or thionyl chloride in a solvent such as dichloromethane to give an intermediate acid chloride. The acid chloride is then treated with trifluoroacetic anhydride and a base such as pyridine following conditions similar to those used by S.Z. Zard (Tetrahedron 51, 2573-2584, 1995) to give the trifluoromethyl ketone 6. Scheme 2 Scheme 2 describes a method of preparing compounds of structure 12. Reaction of an iodo-substituted phenol 7 with a dibromo alkane of structure Br(CH2)nB r the presence of a base such as potassium carbonate gives 8. The bromide 8 is then displaced with a mono or disubstituted amine in the presence of sodium iodide in a solvent such as isopropanol to give 2 or 10. Alternatively, compound 10 can also be obtained under Mitsunobu conditions as described in Scheme 1. Tertiary amines 10 are also obtained by reaction of 9 with various aldehydes RCHO by reaction with a reducing agent such as sodium cyanoborohydride in a solvent such as methanol. Similar tertiary amines 10 are also prepared by reaction of 9 with an iodo compound R(CH2) n I the presence of a base such as potassium carbonate in a solvent such as isopropanol. Reaction of secondary amine 9 with a Michael-type acceptor CH2=CH2-EWG such as ethyl acrylate or acrylonitrile in a solvent such as ethanol also yields substituted amines IQ. Reaction of iodophenol 10 with 4,4,4-trifluorobut-l-en-3-ol (J.A. Pegolotti and W.G. Young, J. Am. Chem. Soc, 1961, S3, 3251), under Heck-type conditions (T. Jeffery, J. Chem. Soc. Chem. Commun., 1287, 1984) in the presence of a palladium catalyst such as palladium (II) acetate in a solvent such as N,N-dimethylformamide gives the allylic alcohol 11. Hydrogenation of this allylic alcohol in the presence of a catalyst such as palladium on activated carbon in a solvent such as ethyl acetate gave an intermediate alcohol which was oxidized to the ketone 12 with the Dess-Martin periodinane (D.B. Dess and J.C. Martin, J. Org. Chem., 1983, 48, 4155) in a solvent such as dichloromethane. Scheme 3 Scheme 3 describes a method of preparing quaternary structures of type 14 and 15. The tertiary amine 13 is alkylated with an alkyl iodide such as methyl iodide or ethyl iodoacetate in a solvent such as isopropanol to give the quaternary amine 14. In the case where one of the R groups contains an ester group, saponification with a base such as potassium hydroxide in a solvent such as aqueous ethanol gives the zwitterionic species 15. Scheme 4 Scheme 4 shows a method of preparing various trifluoromethyl ketones 23 from intermediates in which the trifluoromethyl ketone is protected as a ketal group. Starting from the acid 16 which is commercially available, the trifluoromethyl ketone 17 is prepared using the method described in Scheme 1. The methyl ether 17 is then cleaved with boron tribromide in a solvent such as dichloromethane to give the phenol IS. The ketone group is then protected as a ketal 19 by reaction with an orthoester such as trimethyl orthoformate catalyzed by an acid such as trifluoromethanesulfonic acid and in solvents such as nitromethane and methanol. The phenol 19 is then treated as described for Z in Scheme 2 to give 2Q, 21 and 22- The protected trifluoromethyl ketone in 22 allows various modifications on R such as reduction of an ester group with lithium aluminum hydride or diisobutyl aluminum hydride. The ketal group is then cleaved with an acid such as trifluoroacetic acid to give 23. Scheme 5 Scheme 5 describes preparation of tertiary amines by alkylation of intermediate 21 obtained in Scheme 4 by reaction with an alkyl iodide such as iodopropane in a solvent such as isopropanol and in the presence of a hindered base such as N,N-diisopropylethylamine. The ketal 24 is then cleaved as described in Scheme 4 to give the trifluoromethyl ketone 25. Scheme 6 Scheme 6 describes preparation of a variety of trifluoromethyl ketones 27 starting from the phenol 19 obtained in Scheme 4. Reaction of 19 with various alcohols of structure ROH under the Mitsunobu conditions described in Scheme 1 gave 26. Deprotection of the ketal group as described in Scheme 4 gives 27 possessing a variety of ether substituents. Scheme 7 Scheme 7 shows a synthetic route to acylated or sulfonylated amines 33. Reaction of 4-hydroxybenzaldehyde with a t-butoxycarbonyl- protected amino-alcohol such as 29 under Mitsunobu conditions similar to those described in Scheme 1 gives the aldehyde 3_Q. Aldol condensation of 30 with 1,1,1-trifluoroacetone catalyzed by piperidine and acetic acid using conditions similar to those used by R.S.H. Liu (Tetrahedron Lett., 26, 2873, 1985) gave the enone 3 The enone 31 was then hydrogenated in the presence of a catalyst such as palladium on barium sulfate and treated with Dess-Martin periodinane as described in Scheme 2 to re-oxidize the laJ partially reduced carbonyl group to give 32. The t-butoxycarbonyl- protected amino derivative 32 is then treated with an acid such as trifluoroacetic acid in a solvent such as dichloromethane to give an intermediate amine as a trifluoroacetate salt. This amine is then acylated with various acyl chlorides such as palmitoyl chloride under Schotten- Baumann conditions in a mixture of solvents such as tetrahydrofuran and saturated aqueous sodium acetate to give amide 33. Alternatively, the amine trifluoroacetate salt can be treated with an alkylsulfonyl chloride such as 1-heptanesulfonyl chloride or an alkyl isothiocyanate such as N- decyl isothiocyanate in presence of a base such as triethylamine and in a solvent such as dichloromethane to give a sulfonamide or a thiourea respectively. Scheme 8 Scheme S describes a method of preparing amides of structure 39 which are regioisomers of structures described in Scheme 7. 4- Hydroxybenzaldehyde was treated with 1,1,1-trifluoroacetone as described in Scheme 7 and alkylated with a bromoester such as t-butyl bromoacetate in the presence of a base such as potassium carbonate and in a solvent such as acetone to give 36. Alternatively 36 can be obtained via the same sequence of steps but in inverse order. The phenol 34 can also be acylated with various acid chlorides such as a palmitoyl chloride to give ester derivatives such as 36b. The t-butyl protecting group of 36 is then cleaved with an acid such as trifluoroacetic acid in dichloromethane to give the acid 3_Z. This acid is then reacted with primary and secondary amines such as dodecylamine in the presence of a condensing agent such as N- ethoxycarbonyl-2-ethoxy-l,2-dihydroxyquinoline (EEDQ) to give the amide 3S. Reduction and oxidation of the enone as described in Scheme 7 gave the amide 39. Alternatively, the enone 36 can be reduced first to 40 and then cleaved as above to the acid 41. The acid 41 is then treated with oxalyl chloride in dichloromethane to give an intermediate acid chloride. Reaction of this acid chloride with primary and secondary amines such as p-chlorobenzhydrylamine hydrochloride in a mixture of tetrahydrofuran and saturated aqueous sodium acetate also gives amides of structure 39. feH Scheme 9 Scheme 9 describes a method for making compounds of structure 46. 47 and 48 which contain a sulfur atom. Reaction of an alcohol 43. which contains a sulfur atom, usually obtained by reaction of a thiol with a halogen-substituted alcohol, with phenol 42 under Mitsunobu conditions as described in Scheme 1 gives the ether 44- Preparation of the trifluoromethylketone 46 is then achieved via the two-step sequence also described in Scheme L Oxidation of 4j5 with a peracid such as m- chloroperbenzoic acid gives the sulfone 47. Oxidation of 46 with sodium periodate in a mixture of methanol and water affords the sulfoxide 48. Biological Activity Assay for determining activity as cPLA 2 inhibitors: 3 H-arachidonate-labeled U937 membranes were prepared from U937 cells grown in RPMI 1640 medium containing L-glutamine supplemented with 10% fetal calf serum and 50 μg/ml gentamycin in a 5% C0 2 incubator at 37°C. Sixteen hours prior to harvesting the cells, 3 H- arachidonate (100 Ci/mmol) was added to the cell culture (lxlO 6 cells/ml, 0.5 μCi/ml). After washing the cells with HBSS (Hank's Balanced Salts) containing 1 mg/ml HSA (Human Serum Albumin), the cells were lysed by nitrogen cavitation and the homogenate was centrifuged at 2,000x g for 10 minutes. The supernatant was further centrifuged at 50,000x g for 30 minutes after which the pellet was resuspended in water and autoclaved at 120°C for 15 minutes to inactivate any residual phospholipase A 2 activity. This suspension was then recentrifuged at 50,000x g for 30 minutes and the pellet resuspended in distilled water. Assays of cPLA 2 activity using these 3 H-arachidonate-labeled U937 membranes as substrate typically employ human recombinant cPLA 2 (see Burke et al., Biochemistry 34: 15165-15174, 1995) and membrane substrate (22 μm phospholipid) in 20 mm HEPES [N-(2-hydroxyethyl)ρiperazine-N 1 - (2-ethanesulfonic acid)] buffer, pH 8, containing 6 mm CaCl 2 , 0.9 mg/ml albumin and 4 m glycerol. Enzyme assays are allowed to proceed for 3 hours at 37°C before removing the non-hydrolyzed membranes. The hydrolyzed, radiolabeled fatty acid is then measured by liquid scintillation counting of the aqueous phase. The effects of inhibitor are calculated as percent inhibition of 3 H- arachidonate formation, after correcting for nonenzymatic hydrolysis, as compared to a control lacking inhibitor according to the following formula: percent inhibition = ((Control DPM - Inhibitor DPM)/ Control DPM) x 100% Various concentrations of an inhibitor were tested, and the percent inhibition at each concentration was plotted as log concentration (abscissa) versus percent inhibition (ordinate) to determine the IC 50 values. In this assay the compounds of Examples 1-274 below exhibited cPLA 2 IC S0 values in the range of from about 1 to 50 μm. Since the compounds of the present invention are selective inhibitors of cytosolic phospholipase A 2 , they are of value in the treatment of a wide variety of clinical conditions. Inflammatory disorders which may be treated by inhibition of cytosolic cPLA 2 include such conditions as arthritis, psoriasis, asthma, inflammatory bowel disease, gout, trauma-induced inflammation such as spinal cord injury, Alzheimer's Disease, cerebral ischemia, chronic skin inflammation, shock, damage to skin resulting from exposure to ultraviolet light or burns, allergic rhinitis, acute pancreatitis, and the like. The compounds of formula I are usually administered in the form of pharmaceutical compositions. They can be administered by a variety of routes including oral, rectal, transdermal, subcutaneous, intravenous, intramuscular, and intranasal. The compounds are effective as both injectable and oral compositions. Such compositions are prepared in a manner well known in the pharmaceutical art and comprise at least one active compound defined by formula I and a pharmaceutically acceptable carrier. In making the compositions employed in the present invention the active ingredient is usually mixed with an excipient, diluted by an excipient or enclosed within a carrier which can be in the form of a capsule, sachet, paper or other container. When the excipient serves as a diluent, it can be a solid, semisolid, or liquid material, which acts as a vehicle, carrier or medium for the active ingredient. Thus, the compositions can be in the form of tablets, pills, powders, lozenges, sachets, cachets, elixirs, suspensions, emulsions, solutions, syrups, aerosols (as a solid or in a liquid medium), ointments containing for example up to 10% by weight of the active compound, soft and hard gelatin capsules, suppositories, sterile injectable solutions, and sterile packaged powders. In preparing a formulation, it may be necessary to mill the active compound to provide the appropriate particle size prior to combining with the other ingredients. If the active compound is substantially insoluble, it ordinarily is milled to a particle size of less than 200 mesh. If the active compound is substantially water soluble, the particle size is normally adjusted by milling to provide a substantially uniform distribution in the formulation, e.g. about 40 mesh. Some examples of suitable excipients include lactose, dextrose, sucrose, sorbitol, mannitol, starches, gum acacia, calcium phosphate, alginates, tragacanth, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrup and methyl cellulose. The formulations can additionally include: lubricating agents such as talc, magnesium stearate, and mineral oil; wetting agents; emulsifying and suspending agents; preserving agents such as methyl- and propylhydroxybenzoates; sweetening agents; and flavoring agents. The compositions of the invention can be formulated so as to provide quick sustained or delayed release of the active ingredient after administration to the patient by employing procedures known in the art. The compositions are preferably formulated in a unit dosage form, each dosage containing from about 5 to about 100 mg, more usually about 10 to about 30 mg, of the active ingredient. The term "unit dosage form" refers to physically discrete units suitable as unitary dosages for human subjects and other mammals, each unit containing a predetermined quantity of active material calculated to produce the desired therapeutic effect, in association with a suitable pharmaceutical excipient. The active compound is effective over a wide dosage range. For example, dosages per day normally fall within the range of about 0.5 to about 30 mg/kg of body weight. In the treatment of adult humans, the range of about 1 to about 15 mg/kg/day, in single or divided dose, is especially preferred. However, it will be understood that the amount of the compound actually administered will be determined by a physician, in the light of the relevant circumstances, including the condition to be treated, the chosen route of administration, the actual compound administered, the age, weight, and response of the individual patient, and the severity of the patient's symptoms, and therefore the above dosage ranges are not intended to limit the scope of the invention in any way. In some instances dosage levels below the lower limit of the aforesaid range may be more than adequate, while in other cases still larger doses may be employed without causing any harmful side effect, provided that such larger doses are first divided into several smaller doses for administration throughout the day. SPECIFIC EXAMPLES The following examples further illustrate the preparation of the compounds of formula I. The examples are illustrative only and are not intended to limit the scope of the invention in any way. The following abbreviations have the indicated meanings: AcOH acetic acid EWG electron-withdrawing groups DIAD diisopropyl azodicarboxylate TFAA trifluoroacetic anhydride tθ r.t. room temperature THF tetrahydrofuran TFA trifluoroacetic acid EEDQ N-ethoxycarbonyl-2-ethoxy-l, 2-dihydroxyquinoline DMF N,N-dimethylformamide DEAD diethyl azodicarboxylate CPBA m-chloroperbenzoic acid Me CH 3 Ph phenyl tBu tert-butyl Scheme 1 2 Me R R 2) TFAA-Pyridine l Example 1 4-r4-F2-(N-Dodecyl-N-methylamino)ethoxy)phenyni.l,l-trifluoro-2- butanone N-Methyl-N-Dodecylethanolamine A solution of iodododecane (18.1 g, 61.09 mmol) and 2- (methylamino)ethanol (23.0 g, 0.3 mol) in isopropanol (75 ml) was heated under reflux for 3 h. The cooled mixture was diluted with ether (500 ml), washed with water, brine and dried (magnesium sulfate). Evaporation of the solvent under reduced pressure and distillation of the residue under vacuum gave 14.5 g (97%) of N-methyl-N-dodecylethanolamine as a clear oil: b.p. 100-lll°C/0.3 torr (bulb to bulb distillation, air bath temperature). IR (NaCl, film) u max (cm "1 ) 3400 (OH). 1 H NMR 400 MHz (CDCI3) d (ppm): 0.89 (3H, t, J=5.36 Hz, CH3), 1.1-1.5 (20H, br m, (CH2)lθ)/ 2.24 (3H, s, NCH3), 2.39 (2H, t, J=7.4 Hz, NCH2), 2.52 (2H, t, J=5.35 Hz, OCH2CH2N), 3.58 (2H, t, J=5.35 Hz, OCH?CH?N). 1\ 3-[4-[2-fN-Dodecyl-N-methylaminokthoxy]phenyl]-propanoic acid methyl ester A solution of methyl 3-(4-hydroxyphenyl)propionate (10.0 g, 55. 5 mmol), N-methyl-N-dodecylethanolamine (13.5 g, 55.5 mmol) and triphenylphosphine (16.0 g, 61.0 mmol) in dry tetrahydrofuran (200 ml) was treated at 22°C with diisopropyl azodicarboxylate (12.3 g, 61.0 mmol) added dropwise over 50 min. After 3 h at 22°C, the reaction mixture was evaporated under reduced pressure and the residue was triturated with hexane. The solid formed was filtered, washed with hexane and the combined filtrate was chromatographed on silica gel using a gradient of ethyl acetate in hexane (20% - 60%) as eluent. Distillation under vacuum then gave 18.0 g (75%) of 3-{4-[2-(N-dodecyl-N- methylamino)ethoxy]phenyl} propanoic acid, methyl ester as a clear oil: b.p. 180-183°C/0.02 torr (bulb to bulb distillation, air bath temperature). α H NMR 400 MHz (CDCI3) d (ppm): 0.89 (3H, t, J=6.8 Hz, CH3), 1.2-1.6 (20H, m, CH2)10)/ 2.33 (3H, s, NCH3), 2.43 (2H, t, J=7.6 Hz, NCH2), 2.60 (2H, t, J=7.77 Hz, CH2-2), 2.78 (2H, t, J=6.06 Hz, OCH2CH2N), 2.89 (2H, t, J=7.77 Hz, CH2-3), 3.67 (3H, s, OCH3), 4.04 (2H, t, J=6.06 Hz, OCH2CH2N), 6.84 (2H, d, J=8.55 Hz, aromatic), 7.11 (2H, d, J=8.55 Hz, aromatic). The hydrochloride salt was obtained by treating the amine with anhydrous hydrochloric acid (IM) in ether. Anal. Calcd. for C25H43NO3.HCI: C 67.92, H 10.03, N 3.17. Found: C 67.74, H 9.46, N 3.25. 3-[4-[2-fN-Dodecyl-N-methylamino)ethoxy1phenyl]-propanoic acid. hydrochloride salt. CH 2 CH 2 C0 2 Me CH 2 CH 2 C0 2 H A solution of 3-[4-[2-(N-dodecyl-N-methylamino)ethoxy]phenyl]propanoic acid methyl ester (2.30 g, 5.69 mmol) in ethanol (25 ml) was treated with potassium hydroxide (0.64 g, 11.4 mmol) and water (5 ml) and stirred at 22°C for 2 h. The reaction mixture was then acidified to pH 4 with IM hydrochloric acid and extracted twice with ethyl acetate. The combined extracts were washed with brine, dried (MgSθ4) and evaporated under reduced pressure to give a white solid. Recrystallization from ethyl acetate gave 2.20 g (89%) of 3-[4-[2-(N-dodecyl-N- methylamino)ethoxy]phenyl]propanoic acid as white crystals. IR (KBr) Umax (cm "1 ) : 1725 (C=0 of carboxylate). ! H NMR 400 MHz (CDCI3) d (ppm) : 0.89 (3H, t, J=6.8 Hz, -CH3), 1.2-1.4 (18H, br m, (CH2)9), 1-8 (2H, m, NCH2CH2), 2.61 (2H, t, J=7.5 Hz, CH2-2), 2.87 (3H, s, NCH3), 2.88 (2H, t, J=7.5 Hz, CH2-3), 3.11 (2H, br t, NCΗ2CH2), 3.44 (2H, br t, OCH2CH2N), 4.41 (2H, br t, OCH9CH9N). 6.81 (2.11, d, J=8.58 Hz, aromatic), 8.56 (2H, d, J=8.58 Hz, aromatic). Anal. Calcd. for C24H41NO.HCI: C 67.34, H 9.89, N 3.27. Found: C 67.08, H 9.82, N 3.18. 4-[4-[2-(N-Dodecyl-N-methylamino ethoxy]phenyl]l.l.l-trifluoro-2- butanone A solution of 3-[4-[2-(N-dodecyl-N-methylamino)ethoxy]phenyl]propanoic acid hydrochloride salt (3.30 g, 7.71 mmol) in dry dichloromethane (35 ml) was treated with oxalyl chloride (1.61 g, 12.7 mmol) and a small drop of N,N- dimethylformamide. After 1 h at 22°C, the solvent and excess reagent were evaporated under reduced pressure and the residue was dissolved in dry dichloromethane (35 ml). This solution was then added to a solution of trifluoroacetic anhydride (5.31 g, 24.2 mmol) in dry dichloromethane (30 ml) cooled to 0°C and treated dropwise with pyridine (1.4 ml, 17.3 mmol). After stirring for 30 min at 0°C and another 1.5 h at 22°C, the reaction mixture was cooled again to 0°C and treated dropwise with water (13 ml). After 30 min at 0°C and another 30 min at 22°C, the reaction mixture was adjusted to pH 8-9 with solid sodium bicarbonate and diluted with dichloromethane (200 ml). The organic phase was then washed with brine and dried (magnesium sulfate). The solvent was evaporated under reduced pressure and the residual oil was chromatographed on silica gel. Elution with a gradient of ethyl acetate in hexane gave an oil which was distilled under vacuum to give 2.45 g (71%) of 4-[4-[2-(N-dodecyl-N-methylamino)ethoxy]phenyl]l,l,l- trifluoro-2-butanone as a clear oil: b.p. 160°C/0.02 torr (bulb to bulb distillation, air bath temperature). IR (NaCl, film) u max (cm "1 ) : 1760 (C=0). NMR 400 MHz (CDCI3) d (ppm) : 0.89 (3H, t, J=6.8 Hz, -CH3), 1.1-1.6 (20H, m, (CH2)10) / 2.32 (3H, s, NCH3), 2.44 (2H, t, J=7.6 Hz, NCH2), 2.79 (2H, t, J=6.0 Hz, OCH2CH2N), 2.94 and 3.0 (2 x 2H, 2m, CH2-3 and 4), 4.06 (2H, t, J=6.0 Hz, OCH2CH2N), 6.86 (2H, d, J=8.6 Hz, aromatic), 7.10 (2H, d, J=8.6 Hz, aromatic). Anal. Calcd. for C25H40F3NO2.O.6 H2O: C 68.08, H 9.09, N 3.16. Found: C 68.08, H 9.19, N 3.11. The hydrochloride salt was obtained by treating the amine with anhydrous hydrochloric acid (IM) in ether. Anal. Calcd. for C25H40F3NO2.HCI . 1.1 H2O: C 60.07, H 8.71, N 2.80. Found: C 59.99, H 8.62, N 2.98. Example 2 4-f4-[3-(N-Dodecyl-N-methylamino)propoxy1phenyn-l.l,l-trifluoro-2- butanone 3-(N-dodecyl-N-methylamino propanol A solution of 3-(methylamino)propanol (5.71 g, 64.0 mmol, S. Koepke, R. Kupper, and C.J. Michejda, J. Org. Chem., 44, 2718, 1979)), and iodododecane (7.58 g, 25.6 mmol) was reacted as described in example 1 to give 6.33 g (96%) of the title material as an oil, b.p. 100-105°C/0.04 torr. 3-[4-[3-(N-dodecyl-N-methylamino)propoxy]phenyl]propanoic acid- methyl ester. Methyl 3-(4-hydroxyphenyl)propanoate (1.0 g, 5.5 mmol) and 3-(N- dodecyl-N-methylamino)propanol (1.43 g, 5.5 mmol) were reacted as described in example 1 to give 1.57 g (43%) of title material as an oil. Anal. Calcd. for C26H45 O3: C 74.42, H 10.81, N 3.34. Found: C 74.02, H 10.54, N 3.49. 3-[4-[3-(N-Dodecyl-N-methylamino)propoxy]phenyl]propanoic acid, hydrochloride 3-[4-[3-(N-dodecyl-N-methylamino)propoxy]phenyl]propanoic acid, methyl ester (1.53 g, mmol) was reacted as described in example 1 to give 1.20 g (74%) of the starting material as an amorphous solid. Anal. Calcd. for C26H45NO3: C 74.42, H 10.81, N 3.34. Found: C 74.02, H 10.54, N 3.49. 4- 4-[3-(N-Dodecyl-N-methylamino)propoxy]phenylll.l.l-trifluoro-2- butanone 3-[4-[3-(N-dodecyl-N-methylamino)propoxy]phenyl]propanoic acid, hydrochloride (0.45 g, 1.11 mmol) was reacted as described in example 1 to give 0.185 g (36%) of the title material as an oil, b.p. 140-160°C/0.04 torr (bulb to bulb distillation, air bath temperature). Anal. Calcd. for C26H42F3NO2.O.2H2O: C 67.71, H 9.27, N 3.04. Found: C 67.75, H 9.35, N 2.90. The hydrochloride was obtained as a syrup. Ho Example 3 4-[4-[4-(N-Dodecyl-N-methylamino)butoxy1phenyni.l,l-trifluoro-2- butanone Methyl 3-[4-(4-brornobutoxy ' )phenyllpropanoate A mixture of methyl 3-(4-hydroxyphenyl) propionate (1.19 g, 6.6 mmol), 1,4-dibromobutane (10 g, 46.3 mmol) and powdered anhydrous potassium carbonate (2.3 g) was maintained at 80°C and stirred vigorously for 24 h. Alter cooling, the solid was filtered and washed with a mixture of hexane and ethyl acetate (4:1). The filtrate was concentrated under reduced pressure and the residue was chromatographed on silica gel. Elution with a gradient of ethyl acetate (0-3%) in toluene gave 1.80 g (86%) of the title material as an oil. Anal. Calcd. for Ci4Hi9Brθ3: C 53.25, H 6.08. Found: C 53.24, H 5.74. 3-[4-[4-(N-Dodecyl-N-methylamino butoxy1phenyl]-propanoic acid, methyl ester A mixture of methyl 3-(4-bromobutoxy)phenyl]propanoate (1.46 g, 4.63 mmol), N-methyldodecylamine (2.31 g, 11.6 mmol) and sodium iodide (50 mg) in acetonitrile (17 ml) was heated at 75°C for 3 h. The reaction mixture was then cooled, diluted with dichloromethane, washed with saturated sodium bicarbonate, brine and dried over anhydrous magnesium sulfate. The solvent was then evaporated under reduced pressure and the residue was chromatographed on silica gel. Elution with 11 a gradient of methanol (0 - 5%) in ether gave 1.69 g (85%) of the title material as an oil. Anal. Calcd. for C27H47NO3: C 79.48, H 10.92, N 3.23. Found: C 74.62, H 10.58, N 3.25. 3-[4-[4-(N-Dodecyl-N-methylamino butoxy]phenyl]-propanoic acid, hydrochloride 3-[4-[4-N-dodecyl-N-methylamino)butoxy]phenyl]propanoic acid, methyl ester (0.800 g, 1.84 mmol) was saponified as described in example 1 to give 0.778 g (93%) of the title material as white crystals after crystallization from ethyl acetate; m.p. 109 - 111°C Anal. Calcd. for C26H45NO3.HCI: C 68.47, H 10.17, N 3.07. Found: C 68.49, H 9.92, N 3.07. 4- [4- [4-f N-Dodecy l-N-methylamino ' )butoxy ] phenyl] -1.1,1 -trifluoro-2- butanone 3-[4-[4-(N-dodecyl-N-methylamino)butoxy]phenyl]-propanoic acid, hydrochloride (0.740 g, 1.76 mmol) was reacted as described in example 1 to give 0.420 g (51%) of the title material as an oil: b.p. 150 - 180°C/0.025 torr (bulb to bulb distillation, air bath temperature). Anal. Calcd. for C27H44F3NO2: C 68.76, H 9.40. Found: C 68.52, H 9.38. The hydrochloride was obtained as a syrup. Anal. Calcd. for C27H44F3NO2.HCI.O.5 H2O: C 62.71, H 8.97, N 2.71. Found: C 62.69, H 8.71, N 2.76. Example 4 f2-[2-(N-Dodecyl-N-methylamino)ethoxy1phenyn-2.2,2-trifluoroethanone 2-Trifluoroacetylphenol (Matsumoto, S. ; Kobayashi, H. and Ueno, K. Bull.Chem. Soc. Jpn. 1969, 42, 960) (490mg, 2.57mmol) and 2-[N-dodecyl-N- methylamino] ethanol (627mg, 2.58mmol) were reacted by the general procedure as described in example 1 and afforded the title compound (654mg, 61%) as a pale yellow oil. Analysis for C23H36F3NO2 .3H2O calcd. C 65.63%, H 8.76%, N 3.33%; Found: C 65.44%, H 8.74%, N 3.48%. Treatment of the above free amine with anhydrous hydrogen chloride (1.0 M in ether) gave the hydrochloride salt as a white waxy solid. Analysis for C23H36F3NO2ΗCIO.5H2O calcd. C 59.92%, H 8.31%, N 3.04%; Found: C 59.67%, H 8.49%, N 3.16%. Example 5 4-f4-l2-(N-Dodecyl-N-methylamino)ethoxyl-2-methoxyphenyn-l,l,l- trifluoro-2-butanone 7- 2-(N-Dodecyl-N-methylamino ethoxy]-2H-l-benzopyran-2-one 7-Hydroxycoumarin (6.0g, 37.0mmol) and 2-[N-dodecyl-N-methylamino] ethanol (9.0g, 37.0mmol) were reacted by the general procedure as described in example 1 and afforded the title compound (6.7g, 47%) as a white solid. Analysis for C24H37NO3 calcd C 74.38%, H 9.62%, N 3.61%; Found: 74.35%, H 9.45%, N 3.66%. 7-[2-(N-Dodecyl-N-methylamino ethoxy]-3.4-dihydro-2H-l-benzopyran-2- one 7-[2-(N-Dodecyl-N-methylamino)ethoxy]-2H-l-benzopyran-2-one (5.62g, 14.5mmol) in ethyl acetate was hydrogenated over palladium on activated carbon uder 30 psi and afforded the title compound (4.7g, 84%) as a white solid. Treatment of the above free amine with anhydrous hydrogen chloride (1.0 M in ether) gave the hydrochloride salt as a white solid. Analysis for C24H39N O3-HC.l-O.7H2O calcd. C 65.72%, H 9.51%, N 3.19%; Found: C 65.76% H 9.35% N 3.26%. 3-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]-2-hydroxyphenyl]propanoic acid, methyl ester A solution of 7-[2-(N-Dodecyl-N-methylamino)ethoxy]-3,4-dihydro-2H-l- benzopyran-2-one (2.0g, 5.13mmol) in methanol (30ml) was stirred at 22°C for 0.5h. The solvent was then removed in vacuo at 40°C to afford the title compound (2.14g, 100%) as a white solid. 3-[4-f2-(N-Dodecyl-N-methylamino)ethoxy]-2-methoxyphenyl]propanoic acid, methyl ester 3-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]-2-hydroxyphenyl]propanoic acid, methyl ester (500mg, 1.18mmol) and methanol (0.096ml, 2.37mmol) were reacted under Mitsunobu conditions as described in example 1 and afforded the title compound (471mg, 81%) as a pale yellow oil. 3-r4-[2-fN-Dodecyl-N-methylamino ethoxy]-2-methoxyphenyl]propanoic acid, hydrochloride 3-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]-2-methoxyphenyl]propanoic acid, methyl ester (468mg, 1.07mmol) was saponified as described in the preparation of 3-[4-[2-(N-dodecyl-N- methylamino)ethoxy]phenyl]propanoic acid, hydrochloride and afforded the title compound (280mg, 62%) as a white solid. Analysis for C25H43NO4 calcd. C 64.60%, H 9.46%, N 3.01%; Found: C 64.69%, H 9.52%, N 3.22%. 4-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]-2-methoxyphenyl]-l,l,l- trifluoro-2-butanone 3-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]-2-methoxyphenyl]propanoic acid, hydrochloride (274mg, 0.598mmol) was reacted by the general procedure as described in the preparation of 4-[4-[2-(N-dodecyl-N- methylamino)- ethoxy]phenyl]-l,l,l-trifluoro-2-butanone and afforded the title compound (165mg, 58%) as a pale yellow oil (b.p. 138- 140°C/0.015mmHg). Treatment of the above free amine with anhydrous hydrogen chloride (1.0 M in ether) gave the hydrochloride salt as a off-white sticky solid. Analysis for C26H4 . 2F3NO3-HCl-O.7H2O calcd. C 58.80%, H 8.76%, N 2.74%; Found: C 58.89%, H 8.53%, N 2.64%. Example 6 7-r2-(N-Dodecyl-N-methylamino)ethoxyl-3,4-dihydro-2-(trifluoromethyl)- 2H-l-benzopyran-2-ol A mixture of 4-[4-[2-(N-dodecyl-N-methylamino)ethoxy]-2- methoxyphenyl]-l,l,l-trifluoro-2-butanone (157mg, 0.33mmol) and hydrobromic acid (47%, 3ml) was refluxed for 3.5h. After cooling to r.t, the mixture was diluted with water, extracted with dichloromethane. The organic layer was washed with sat. sodium bicarbonate, brine, dried over magnesium sulfate and concentrated in vacuo. The residue was chromatographed on silica gel (ethyl acetate /acetone 3 : 1) to afford the title compound (60mg, 40%) as a clear oil. Treatment of the above free amine with anhydrous hydrogen chloride (1.0 M in ether) gave the hydrochloride salt as a off-white sticky solid. Analysis for C25H40F3NO3ΗCIO.3H2O calcd. C 59.88%, H 8.36%, N 2.79%; Found: C 59.84%, H 8.29%, N 2.79%. Example 7 4-f4-f2-(N-Dodecyl-N-methylamino)ethoxy1-2-vinylphenyn-l,l.l-trifluoro- 2-butanone 3-r4-r2-(N-Dodecyl-N-methylamino')ethoxyl-2- ftrifluoromethanesulfonyloxy] phenyl] propanoic acid, methyl ester S i To a solution of 3-[4-[2-(N-dodecyl-N-methylamino)ethoxy]-2- hydroxyphenyl]propanoic acid, methyl ester (2.53g, ό.Ommol) and dry pyridine (1.94ml, 24.0mmol) in dichloromethane (30ml) at 0°C was added dropwise trifluoromethanesulfonic anhydride (2.1ml, 12.0mmol). After stirring for 20h at 22°C, the mixture was diluted with ethyl acetate (120ml), washed with water (3x50ml), brine (50ml), dried over magnesium sulfate and concentrated in vacuo. The residue was placed at 0°C and triturated with diethyl ether. The formed solid (trifluoromethanesulfonic acid salt of the title compound) was dissolved in dichloromethane, washed with sat. sodium bicarbonate, brine and dried over magnesium sulfate. The solvent was removed in vacuo to afford the title compound (2.15g, 69%) as a brown oil which solidified upon standing. 3-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]-2-vinylphenyllpropanoic acid. methyl ester To a solution of 3-[4-[2-(N-dodecyl-N-methylamino)ethoxy]-2- [trifluoromethanesulfonyloxy]- phenyl]propanoic acid, methyl ester (250mg, 0.48mmol) in 1,4-dioxane (2.5ml) were added tributylvinyltin (1.2ml, 4.0mmol), lithium chloride (123mg, 1.44mmol), tetrakis(triphenylphosphine)-palladium(0) (10mg) and 2,6-di-terf-butyl-4- methylphenol (lOmg). The resulting mixture was then stirred at 100°C for 5h. After cooling to r.t., the mixture was diluted with diethyl ether, washed with water, brine, dried over magnesium sulfate and concentrated in vacuo. The residue was chromatographed on silica gel (diethyl ether/acetone 100 : 0 to 80 : 20) to afford the title compound (170mg, 80%) as a yellow oil. 3-[4-[2-(N-Dodecyl-N-methylamino ethoxy]-2-vinylphenyl]propanoic acid. hydrochloride 3-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]-2-vinylphenyl]propanoic acid, methyl ester (178mg, 0.412mmol) was saponified as described in the preparation of 3-[4-[2-(N-dodecyl-N- methylamino)ethoxy]phenyl]propanoic acid, hydrochloride and afforded the title compound (175mg, 93%) as a clear oil. n. 4-[4-[2-(N-Dodecyl-N-methylamino ' )ethoxy]-2-vinylphenyl1-l,l,l-trifluoro- 2-butanone 3-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]-2-vinylphenyl]propanoic acid, hydrochloride (830mg, 1.83mmol) was reacted by the general procedure as described in the preparation of 4-[4-[2-(N-dodecyl-N-methylamino)- ethoxy]phenyl]-l,l,l-trifluoro-2-butanone. The residue was chromatographed on silica gel (ethyl acetate) to afforded the title compound (0.46g, 54%) as a pale purple oil. Analysis for C27H42F3 O2-0.5H2O calcd. C 67.75%, H 9.06%, N 2.93%; Found: C 67.85%, H 8.92%, N 2.90%. Treatment of the above free amine with anhydrous hydrogen chloride (1.0 M in ether) gave the hydrochloride salt as a pale green sticky solid. Analysis for C27H42F3NO2ΗCM.3H2O calcd. C 61.24%, H 8.68%, N 2.65%; Found: C 61.07%, H 8.42%, N 2.63%. Example 8 8-r2-(N-Dodecyl-N-methylamino)ethoxyl-3-hydroxy-l-(hydroxymethyl)-3- (trifluoromethyl)-l,3,4,5-tetrahydro-2-benzoxepin A solution of 4-methylmorpholine N-oxide (31mg, 0.23mmol) and osmium tetroxide (lmg, 0.004mmol) in acetone (1ml) and water (2.5ml) was treated with 4-[4-[2-(N-dodecyl-N-methylamino)ethoxy]-2- vinylphenyl]-l,l,l-trifluoro-2-butanone (lOOmg, 0.21mmol) dissolved in tert-butanol (1ml). After stirring at 22°C for 16h, the mixture was treated with aqueous sodium bisulfite (20%, 5ml) and extracted with diethyl ether. The combined organic layers were washed with brine, dried over magnesium sulfate and concentrated in vacuo. The residue was chromatographed on silica gel (diethyl ether /acetone 80 : 20 to 50 :50) to afford the title compound (40mg, 39%) as a clear oil. Treatment of the above free amine with anhydrous hydrogen chloride (1.0 M in ether) gave the hydrochloride salt as an off-white solid. Analysis for C27H4 F3NO4-HC1-0.7H2O calcd. C 58.67%, H 8.46%, N 2.53%; Found: C 58.67%, H 8.18%, N 2.45%. Si Example 9 4-r4-f2-fN-[Bis-(4-chlorophenyl)methynN-methylamino1ethoxy1phenyl1- l f l.l-trifluoro-2-butanone. 2-fN-[Bis-( " 4-chlorophenyDmethyl]N-methylamino]ethanol A solution of 4,4'-dichlorobenzhydryl chloride (5.20 g, 19.1 mmol) and 2- (methylamino)ethanol (9.0 g, 0.106 mol) in acetonitrile (100 ml) was treated with powdered anhydrous potassium carbonate (10 g) and the resulting mixture was heated under reflux for 4 h. The cooled mixture was filtered and the filtrate was concentrated in vacuo. The residual oil was diluted with ethyl acetate, washed with water and brine and then dried over anhydrous magnesium sulfate. Evaporation of the solvent i n vacuo followed by chromatography on silica gel (elution toluene-ethyl acetate 9:1) gave 4.29 g (79%) of the title material as a white solid: mp 49- 50°C. Anal. Calcd. for Cι 6 Hi7Cl 2 N0: C 61.95, H 5.52, N 4.52. Found: C 61.58, H 5.43, N 4.61. SH 3-[4-[2-[N-[Bis-(4-chloropheny methyl]-N-methylamino]ethoxy]phenyl]- propanoic acid methyl ester. A solution of methyl 3-[4-hydroxyphenyl)propanoate (0.594 g, 3.3 mmol) and 2-[N-[bis-(4-chlorophenyl)methyl]-N-methylamino]ethanol and triphenylphosphine (0.952 g, 3.63 mmol) in tetrahydrofuran (12 ml) was treated dropwise at 22°C with diisopropyl azodicarboxylate (0.734 g, 3.63 mmol). After 3 h, the solvent was evaporated in vacuo and the residue was chromatographed on silica gel (elution hexane-ethyl acetate 83:17) to give 1.12 g (72%) of the title material as an oil. Anal. Calcd. for C 2 6H27CI 2 NO3. 0.4 H 2 0: C 65.11, H 5.84, N 2.92. Found: C 65.34, H 5.89, N 3.08. 3-r4-[2-[N-[Bis-(4-chlorophenyDmethynmethyl]-N- methylamino]ethoxy]phenyl]propanoic acid. A solution of 3-[4-[2-(bis-(4-chlorophenyl)methyl]-N- methylamino]ethoxy]phenyl]-propanoic acid methyl ester (0.80 g, 1.7 mmol) in ethanol (7 ml) was treated with potassium hydroxide (0.2 g, 3.5 mmol) in water (2.4 ml) and the resulting mixture was stirred at 45°C for 2 h. The cooled mixture was adjusted to pH 4 with HCI IN and concentrated in vacuo. The residue was partitioned between dichloromethane and water and the aqueous phase was extracted a second time with dichloromethane. The combined organic phases were dried over anhydrous magnesium sulfate and evaporated to give 0.746 g (95%) of the title material as an amorphous solid. Anal. Calcd. for C25H25CI2NO3.O.I C 7 H 8 : C 66.01, H 5.56, N 3.00. Found: C 66.21, H 5.91, N 3.01. 4-[4-[2-[N-[Bis-(4-chlorophenyl)methyl]-N-methylamino]ethoxy]phenyl]- 1.1 ,1-trif luoro-2-butanone. A solution of 3-[4-[2-[N-[Bis-(4-chlorophenyl)methyl]-N- methylamino]ethoxy]phenyl]-propanoic acid (0.592 g, 1.29 mmol) in dichloromethane (10 ml) was treated at 22°C with oxalyl chloride (0.25 g, 1.97 mmol) and the resulting mixture was stirred for 1.5 h. The solvent was evaported in vacuo and the crude acid chloride was diluted with toluene (20 ml) and cooled to 0°C. Then trifluoroacetic anhydride (0.81 g, 3.87 mmol) was added followed by pyridine (0.22 g, 2.8 mmol) added dropwise over 10 min. The resulting mixture was then stirred at 22°C for 2.5 h. The mixture was then cooled to 0°C and treated dropwise with water (1 ml) and stirred for 15 min. The reaction mixture was then diluted with ethyl acetate, washed with saturated sodium bicarbonate, brine, and dried (magnesium sulfate). Evaporation of the solvent in vacuo and chromatography of the residue on silica gel (elution toluene ethyl acetate, 92:8) gave 0.465 g (70%) of title material as an oil. Anal. Calcd. for C26H24CI2F3NO2: C 61.19, H 4.74, N 2.74. Found: C 61.17, H 4.60, N 2.96. The hydrochloride salt was obtained as an amorphous solid. Anal. Calcd. for C26H24CI2F3NO2.HCI: C 57.11, H 4.61, N 2.56. Found: C 57.09, H 4.97, N 2.38. Example 10 4-r4-r2-rN-f3-Bis-(4-chlorophenyl)propyllN-methylamino1ethoxylphenyn- l,l.l-trifluoro-2-butanone. 3-Bis-(4-chloropheny propanoic acid, ethyl ester. Ethyl bromoacetate (3.0 g, 18.0 mmol) was added dropwise to a boiling solution of zinc powder (1.7 g, 26.0 at g) and iodine (30.0 mg) in dichloromethane (5 ml) to form the Reformatsky reagent (K. Bott, Tetrahedron Lett., 1984, 35, 555-556). The mixture was then cooled to 0°C and treated dropwise with a solution of 4,4'-dichlorobenzhydryl chloride (5.11 g, 15.8 mmol) in dichloromethane (10 ml) and the resulting mixture was stirred at 22°C for 3 h. The reaction mixture was then diluted with ether, washed with 10% sulfuric acid, brine and dried (magnesium sulfate). Evaporation of the solvent in vacuo gave an oil which was chromatographed on silica gel to give 2.99 g (59%) of the title material as an oil: bp 110-115°C/0.1 torr. Anal. Calcd. for C17H16CI2O2: C 63.17, H 4.99. Found: C 62.94, H 4.90. %1 3-Bis-(4-chlorophenyl)propanoic acid. A solution of 3-Bis-(4-chlorophenyl)propanoic acid, ethyl ester (2.80 g, 8.66 mmol) in ethanol (40 ml) was treated with potassium hydroxide (1.0 g, 15.2 mmol) in water (10 ml) and the resulting mixture was heated at 60°C for 1 h. The cooled mixture was concentrated in vacuo, water and dichloromethane were added and the aqueous phase was adjusted to pHβ with 2N hydrochloric acid. The aqueous phase was extracted two times with dichloromethane and the combined organic extracts were dried (magnesium sulfate). Evaporation of the solvent gave 2.40 g (94%) of the title material as a white solid: mp 188-189°C. XI N-(2-HydroxyethylVN-methyl-3-bis-(4-chlorophenyDpropanamide. A solution of 3-Bis-(4-chlorophenyl)propanoic acid (2.33 g, 7.89 mmol) in dry dichloromethane (75 ml) was treated at 22°C with oxalyl chloride (2.18 g, 17.2 mmol) and a small drop of N,N-dimethyl formamide. After lh, the solvent and excess reagent were evaporated in vacuo. The residual oil was diluted with dry tetrahydrofuran (10 ml) and added dropwise to a vigorously stirred solution of 2-(methylamino) ethanol (0.75 g, 10.0 mmol) in tetrahydrofuran (15 ml) and water (15 ml) containing sodium bicarbonate (1 g). After 2 h at 22°C, the mixture was diluted with ethyl acetate, washed with brine and dried (magnesium sulfate). Evaporation of the solvent under vacuum and chromatography of the residue on silica gel (elution dichloromethane-methanol 95:5) gave 2.63 g (93%) of the title material as an oil. 2-[N-[3-Bis-(4-chlorophenyl propyl]-N-methylamino1ethanol. A solution of N-(2-hydroxyethyl)-N-methyl-3-bis-(4- chlorophenyl)propanamide (2.63 g, 7.47 mmol) in dry tetrahydrofuran (35 ml) was treated with solid lithium aluminum hydride (0.66 g, 17.4 mmol) added in small portion over 10 min. The resulting mixture was then heated at 60°C for 2.5 h. The cooled solution was then quenched by successive addition of water (1 ml), 10% sodium hydroxide (1 ml) and water (2 ml). The solid formed was filtered and the filtrate was dried (magnesium sulfate) and concentrated in vacuo. The residual oil was chromatographed on silica gel (elution ethyl acetate and methanol 0-20%) to give 1.72 g (68%) of the title material as an oil. Anal. Calcd. for Cι 8 H 2 ιCl 2 NO: C 63.91, H 6.26, N 4.14. Found: C 63.95, H 6.13, N 3.81. 3-[4-[2-[N-[3-Bis-(4-chlorophenyl)propyl]-N-methylamino]ethoxy]phenyl]- propanoic acid, methyl ester. A solution of methyl 3-(4-hydroxyphenyl)propanoate (0.80 g, 4.44 mmol), 2-[N-[3-bis-(4-chlorophenyl)propyl]-N-methylamino]ethanol (1.62 g, 4.79 mmol) and triphenyl-phosphine (1.51 g, 5.76 mmol) in dry benzene (20 ml) was treated dropwise at 22°C with diethyl azodicarboxylate (1.00 g, 5.77 mmol). After 3h at 22°C, the reaction mixture was diluted in the ethyl acetate, washed with saturated sodium bicarbonate, brine and dried (magnesium sulfate). Evaporation of the solvent under vacuo and chromatography of the residue on silica gel (elution toluene-ethyl acetate 0-15%) gave 0.893 g (40%) of the title material as an oil. Anal. Calcd. for C28H31CI2NO3.O.2 H 2 0: C 66.72, H 6.28, N 2.78. Found: C 66.60, H 6.31, N 2.92. 3-[4-[2-[N-[3-Bis-(4-chlorophenyl)propyl]-N-methylamino]ethoxy]phenyl]- propanoic acid, hydrochloride salt. A solution of 3-[4-[2-[N-[3-Bis-(4-chlorophenyl)propyl]-N- methylamino]ethoxy]phenyl]-propanoic acid, methyl ester (0.801 g, 1.60 mmol) in ethanol (16 ml) was treated with potassium hydroxide (0.25 g, 3.8 mmol) in water (4 ml) and the resulting mixture was heated at 60°C for 1 h. After cooling, the reaction mixture was concentrated in vacuo and the residue was diluted with water and dichloromethane. The aqueous phase was adjusted to pH 4 with 2N hydrochloric acid and extracted two times with dichloromethane. The combined organic extracts were dried (magnesium sulfate) and evaported in vacuo to give 0.700 g (90%) of the title material as a white foam. Anal. Calcd. for C27H29CI2NO3.O.7 HCI: C 63.34, H 5.85, N 2.74. Found: C 63.13, H 5.88, N 2.73. ^3 4-[4-[2-[N-[3-Bis-(4-chlorophenyl)propyl]-N-methylamino]ethoxy]phenyl]- 1.1 ,1-trif luoro-2-butanone. A solution of 3-[4-[2-[N-[3-Bis-(4-chlorophenyl)propyl]-N- methylamino]ethoxy]phenyl] propanoic acid, hydrochloride salt (0.660 g, 1.36 mmol) in dry dichloromethane (30 ml) was treated with oxalyl chloride (0.45 g, 3.5 mmol) and a trace of N,N-dimethylformamide. After 1 h at 25°C, the solvent and excess reagents were evaporated in vacuo. The residual oil was dissolved in dry toluene (30 ml), cooled to 0°C and then treated with trifluoroacetic anhydride (0.6 ml, 4.25 mmol) followed by pyridine 0.3 ml, 3.71 mmol) added dropwise over 10 min. The resulting mixture was then stirred at 22°C for 2.5 h. After cooling again to 0°C, water (5 ml) was added dropwise and the mixture was stirred at 22°C for 30 min. The reaction mixture was then diluted with ethyl acetate, washed with saturated sodium bicarbonate, brine and dried (magnesium sulfate). Evaporation of the solvent under vacuum and chromatography of the residue on silica gel (elution gradient of toluene-ethyl acetate 1:1 to ethyl acetate) gave 0.307 g (42%) of the title material as an oil. Anal. Calcd. for C28H28CI2F3NO2.O.5 H 0: C 61.43, H 5.34, N 2.56. Found: C 61.46, H 5.13, N 2.60. The hydrochloride salt was obtained as a white foam. Anal. Calcd. for C28H28CI2F3NO2.HCI. H 2 0: C 56.72, H 5.27, N 2.36. Found: C 56.95, H 4.97, N 2.23. The following compounds may be prepared by the general procedure of Scheme 1. SCHEME 1 TABLE A (CH 2 ) n COCF 3 SCHEME 1 TABLE B <Λ! TABLE B (cont'd.) °ιX Scheme 1, Table B (continued) \ \ 10 15 20 SCHEME 1 TABLE C 1*3 Scheme 2 nol 9 10 Example 48 4-rN-Dodecyl-N-r2-.4-(3-oxo-4,4,4-trifluorobut-l- yDphenoxylethyllaminolbutanoic acid, ethyl ester Method I l-[2-Bromoethoxy]-4-iodobenzene A mixture of 4-iodophenol (15. Og, 68.2mmol) and 1,2-dibromoethane (50ml, 580mmol) and potassium carbonate (14. Og, O.lmol) was stirred and refluxed for 22h. After cooling to r.t, the mixture was filtered, washed with ethyl acetate and concentrated in vacuo. The residue was chromatographed on silica gel (Hexane /ethyl acetate 40 : 1 to 20 : 1) to afford the title compound (18.7g, 84%) as a white solid. N-2-[4-Iodophenoxy]ethyldodecylamine A mixture of dodecylamine (30g, 162mmol), diisopropylethylamine (22ml, 128mmol), sodium iodide (1.3g, 8.5mmol), l-[2-bromoethoxy]-4- iodobenzene (13.9g, 42.5mmol) and isopropanol (250ml) was stirred and refluxed for 24h. After cooling to r.t., the mixture was filtered, washed with dichloromethane and concentrated in vacuo . The residue was chromatographed on silica gel (dichloromethane /methanol 50: 1 to 20 : 1) to afford the title compound (15g, 82%) as a white solid. Analysis for its hydriodide salt C20H34NIO-HI calcd. C 42.95%, H 6.31%, N 2.50%; Found: C 42.73%, H 6.16%, N 2.50%. 4-[N-dodecyl-N-2-[4-iodophenoxy]ethylamino]butanoic acid, ethyl ester To a mixture of N-2-[4-iodophenoxy]ethyldodecylamine ( 4.0g, 9.3mmol) and sodium cyanoborohydride (1.45g, 23mmol) in methanol (80ml) was added dropwise a solution of ethyl 4-oxobutyrate (Fournet, G. ; Balme, G.; Barieux, J.J. and Gore, J. Tetrahedron, 1988, 44, 5821) (2.4g, lδmmol) in methanol (20ml) over a period of lOmin. The resulting mixture was stirred at 22°C for 24h, and then diluted with ethyl acetate (600ml), washed with brine (3x250ml). The aqueous phase was extracted with ethyl acetate (150ml), and the combined organic layers were dried over sodium sulfate and concentrated in vacuo. The residue was chromatographed on silica gel (Hexane /ethyl acetate 8 : 1 to 6 : 1) to afford the title compound (4.5g, 89%) as a colorless oil. Analysis for C26H44N IO3O.3H2O, calcd. C 56.68%, H 8.16%, N 2.54%; Found: C 56.4% H 7.77%, N 2.63%. 4-rN-dodecyl-N-2-f4-( / EVr3-hydroxy-4.4.4-trifluorobut-l-en-l- yl1phenoxy]ethylamino]butanoic acid, ethyl ester To a solution of 4-[N-dodecyl-N-2-[4-iodophenoxy]ethylamino]butanoic acid, ethyl ester (4.5g, 8.3mmol) and 4,4,4-trifluorobut-l-en-3-ol (Pegolotti, J.A. and Young, W.G. /. Amer. Chem. Soc, 1961, 83, 3251) (complex with 1 tetrahydrofuran, 3.3g, 16.6mmol) in N, N-dimethylformamide (17ml) were added sodium bicarbonate (1.75g, 20.8mmol), tetrabutyl ammonium chloride hydrate (2.5g, 8.32mmol) and palladium (II) acetate (56mg, 0.25mmol). The resulting mixture was stirred at 50°C for 24h, and then diluted with ethyl acetate (300ml), washed with brine (100ml), sat. aq. sodium thiosulfate (2x100ml), brine (2x100ml), dried over sodium sulfate and concentrated in vacuo. The residue was chromatographed on silica gel (Hexane/ethyl acetate 4: 1 to 2 : 1) to afford the title compound (3.5g, 78%) as a colorless oil and 0.3g (6.6%) of 4-[N- Dodecyl-N-[2-[4-(4,4,4-trifluoro-3-oxo-but-l- yl)phenoxy] ethyl] amino]butanoic acid, ethyl ester. Analysis for C30H48F3N O4 calcd. C 66.27%, H 8.90%, N 2.58%; Found: C 65.92%, H 8.73%, N 2.59% 4- r ,N-Dodecyl-N-2-r4-r3-hydroxy-4.4.4- trifluorobutyl]phenoxy]ethylamino]butanoic acid, ethyl ester A mixture of 4-[N-dodecyl-N-2-[4-(E)-[3-hydroxy-4,4,4-trifluorobut-l-en-l- yl]phenoxy]ethylamino] butanoic acid, ethyl ester (3.5g, 6.46mmol), palladium on activated carbon (10%, 0.6g) and ethyl acetate (250ml) was hydrogenated under 30psi for 6h. After filtration, the solvent was removed in vacuo to give the title compound (3.3g, 94%) as a colorless oil. 4-[N-Dodecyl-N-[2-f 4-f 3-oxo-4.4 ,4-trifluorobut-l - yPphenoxy] ethyl] amino]butanoic acid, ethyl ester A suspension of 1,1, l-triacetoxy-l,l-dihydro-l,2-benziodoxol-3(lH)-one (Dess-Martin periodinane, 1.7g, 4.0mmol) in dichloromethane (20ml) was treated with 4-[N-dodecyl-N-2-[4-[4,4,4-trifluoro-3- hydroxybutyl]phenoxy]ethylamino]butanoic acid, ethyl ester (430mg, 0.79mmol) dissolved in dichloromethane (5ml). The mixture was stirred at 22°C for 4h, poured into a saturated aqueous sodium bicarbonate and sodium thiosulfate (100ml) and extracted with ethyl acetate (2x100ml). The combined oganic layers were washed with sat. sodium bicarbonate (2x60ml), brine (60ml), dried over sodium sulfate and concentrated in vacuo . The residue was chromatographed on silica gel (hexane /ethyl acetate 2 : 1 to 1.5 : 1) to afford the title compound (333mg, 77%) as a colorless oil. Analysis for C30H48F3N O4 .IH2O calcd. C 63.94%, H 8.98%, N 2.49%; Found: C 63.55% H 8.55% N 2.61%. Treatment of the above free amine with anhydrous hydrogen chloride (1.0 M in ether) gave the hydrochloride salt as a pale yellow syrup. Example 49 3-rN-Dodecyl-N-r2-r4-(3-oxo-4,4.4-trifluorobut-l- yPphenoxylethyllaminolpropanoic acid, ethyl ester 3-[N-Dodecyl-N-[2-[4-iodophenoxy]ethyl]amino]propanoic acid, ethyl ester A mixture of N-2-[4-iodophenoxy]ethyldodecylamine (l.Og, 2.3mmol), ethyl acrylate (1.2g, 12mmol) and ethanol (3ml) was stirred and refluxed for 6h, and then concentrated in vacuo . The residue was chromatographed on silica gel (hexane /ethyl acetate 8 : 1) to afford the title compound (1.05g, 86%) as a colorless oil. Analysis for C25H42IN O3 calcd. C 56.49%, H 7.97%, N 2.64%; Found: C 56.79% H 8.10% N 2.59%. lcn 3- N-Dodecyl-N-2-[4-(EVf3-hydroxy-4,4.4-trifluorobut-l-en-l- yl]phenoxy]ethylamino]propanoic acid, ethyl ester [N-Dodecyl-N-[2-[4-iodophenoxy]ethyl]amino]propanoic acid, ethyl ester (0.95g, 1.79mmol) and 4,4,4-trifluorobut-l-en-3-ol (complex with 0.7 THF, 0.95g, 5.4mmol) were reacted by the general procedure as described in the preparation of 4-[N-dodecyl-N-2-[4-(E)-[3-hydroxy-4,4,4-trifluorobut-l-en-l- yl]phenoxy]ethylamino]butanoic acid, ethyl ester (Example 48 ) and afforded the title compound (0.633g, 76%) as a colorless oil. 3-.N-Dodecyl-N-2-[4-r3-hydroxy-4.4.4- trifluorobutyl]phenoxy]ethylamino]propanoic acid, ethyl ester [N-dodecyl-N-2-[4-(E)-[3-hydroxy-4,4,4-trifluorobut-l-en-l- yl]phenoxy]ethylamino]propanoic acid, ethyl ester (620mg, 1.17mmol) was hydrogenated as described in the preparation of 4-[N-dodecyl-N-2-[4-[3- hydroxy-4,4,4-trifluorobutyl]phenoxy]ethylamino]butanoic acid, ethyl ester (Example 48) and afforded the title compound (573mg, 92%) as a clear oil. Analysis for C29H48F3N O4 calcd. C 65.51%, H 9.10%, N 2.63%; Found: C 65.83% H 9.41% N 2.50%. 3-rN-Dodecy1-N-f2-14-f3-oxo-4.4,4-trifluorobut-l- yl1phenoxy]ethyl]amino]propanoic acid, ethy ester 3-[N-Dodecyl-N-2-[4-[3-hydroxy-4,4,4- trifluorobutyl]phenoxy]ethylamino]propanoic acid, ethyl ester (320mg, 0.60mmol) was oxidized as described in the preparation of 4-[N-dodecyl-N- [2-[4-(3-oxo-4,4,4-trifluorobut-l-yl)phenoxy]ethyl]amino]butanoic acid, ethyl ester (Example 48 ) and afforded the title compound (216mg, 68%) as a pale yellow oil. Analysis for C29H46F3N θ4-0.8H2θcalcd. C 64.02%, H 8.82%, N 2.57%; Found: C 63.94% H 8.85% N 2.59%. Treatment of the above free amine with anhydrous hydrogen chloride (1.0 M in ether) gave the hydrochloride salt as a pale yellow syrup. Analysis for C29H46F3N 04-HCM.5H20 calcd. C 58.72%, H 8.50%, N 2.36%; Found: C 58.45% H 8.22% N 2.55%. Example 50 \c " 4 (2S. 4S)-l-N-Dodecyl-4-r4-(3-hydroxy-4.4.4-trifluorobut-l- yl)phenoxy1pyrrolidine-2-carboxylic acid, methyl ester frflns-4-Hydroxy-L-proline. methyl ester, hydrochloride To a freshly prepared sat. solution of hydrogen chloride in methanol (100ml) was added irαns-4-hydroxy-L-proline (lO.Og, 76.26mmol). The resulting mixture was stirred at 22°C for 24h, concentrated in vacuo and triturated with acetone at 0°C. Filtration afforded the title compound (12.8g, 92%) as a white solid. f2S. 4R)-l-N-Dodecyl-4-hydroxypyrrolidine-2-carboxylic acid, methyl ester A solution of rπms-4-hydroxy-L-proline, methyl ester, hydrochloride (4.0g, 22.02mmol) and 1-iodododecane (3.04g, 44.04mmol) in methanol (30ml) was treated with potassium carbonate. The mixture was stirred and refluxed for 7h, cooled to r.t., diluted with ethyl acetate (700ml), washed with water (400ml), brine (200ml), dried over magnesium sulfate and concentrated in vacuo. The residue was chromatographed on silica gel (petroleum ether /ethyl acetate 60 : 40 to 40 : 60) to afford the title compound (3.72g, 54%) as a white solid. (2S, 4SVl-N-Dodecyl-4-(4-iodophenoxy)pyrrolidine-2-carboxylic acid. methyl ester (2S, 4R)-l-N-Dodecyl-4-hydroxypyrrolidine-2-carboxylic acid, methyl ester (1.75g, 7.94mmol) and 4-iodophenol (2.26g, 7.22mmol) were reacted under Mitsunobu conditions as described in the preparation of 3-[4-[2-(N- Dodecyl-N-methylamino)ethoxy]phenyl]propanoic acid, methyl ester. The residue was chromatographed on silica gel (hexane /ethyl acetate 15 : 1 to 10 : 1) to afford the title compound (3.23g, 79%) as a white solid. [a]o= - 30.80 ( C lι0/ CHCI3) Analysis for C24H38INO3 calcd. C 55.92%, H 7.43%, N 2.72%; Found: C 55.87%, H 7.48%, N 2.68%. t / 2S, 4SVl-N-Dodecyl-4-[4-(EV[3-hydroxy-4.4.4-trifluorobut-l-en-l- yl]phenoxy]pyrrolidine-2-carboxylic acid, methyl ester (2S, 4S)-l-N-Dodecyl-4-(4-iodophenoxy)pyrrolidine-2-carboxylic acid, methyl ester (800mg, 1.55mmol) and 4,4,4-trifluorobut-l-en-3-ol (complex with 1 tetrahydrofuran, 620mg, 3.1mmol) were reacted by the general procedure as described in the preparation of 4-[N-dodecyl-N-2-[4-(E)-[3- hydroxy-4,4,4-trifluorobut-l-en-l-yl]phenoxy]ethylamino]butanoic acid, ethyl ester and afforded the title compound (575mg, 72%) as a colorless oil [[a]D= - 8.7 0 (c 0.8, CHCI3)] and (2S, 4S)-l-N-dodecyl-4-[4-(3-oxo-4,4,4- trifluorobut-l-yl)phenoxy]pyrrolidine-2-carboxylic acid, methyl ester (68mg, 9%) as a pale yellow oil. Analysis for C28H42F3N O4 O.3H2O calcd. C 64.79%, H 8.27%, N 2.70%; Found: C 64.74% H 8.23% N 2.87%. (2S. 4SVl-N-Dodecyl-4-[4-r3-hydroxy-4.4.4-trifluoro-l- butyl]phenoxy]pyrrolidine-2-carboxylic acid, methyl ester (2S, 4S)-l-N-Dodecyl-4-[4-(E)-[3-hydroxy-4,4,4-trifluorobut-l-en-l- yl]phenoxy]pyrrolidine-2-carboxylic acid, methyl ester (552mg., 1.07mmol) was hydrogenated as described in the preparation of 4-[N-dodecyl-N-2-[4- [3-hydroxy-4,4,4-trifluorobutyl]phenoxy] ethylamino]- butanoic acid, ethyl ester, and afforded the title compound (546mg, 99%) as a clear oil. [a]D= - 89.00 ( c 0.4, CHCI3) Analysis for C28H44F3N O4 calcd. C 65.22%, H 8.60%, N 2.72%; Found: C 65.13% H 8.59% N 2.68%. Example 51 (2S.4S)-l-N-Dodecyl-4-r4-(3-oxo-4.4.4-trifluorobut-l- yl)phenoxy1pyrrolidine-2-carboxylic acid, methyl ester (2S, 4S)-l-N-Dodecyl-4-[4-[3-hydroxy-4,4,4- trifluorobutyl]phenoxy]pyrrolidine-2-carboxylic acid, methyl ester_(425mg, 0.825mmol) was oxidized as described in the preparation of 4-[N-dodecyl- N-[2-[4-(3-oxo-4,4,4-trifluorobut-l-yl)phenoxy]ethyl]amino]butanoic acid, ethyl ester . and afforded the title compound (272mg, 64%) as a pale yellow oil. Analysis for C28H42F3N O4O.4H2O calcd. C 64.57%, H 8.28%, N 2.69%; Found: C 64.61% H 8.08% N 2.76%. Treatment of the above free amine with anhydrous hydrogen chloride (1.0 M in ether) gave the hydrochloride salt as a pale yellow foam. [a]D= -9.2° (c 0.74, CHCI3) C28H43F3N O4ΗCM.2H2O calcd. C 58.82%, H 8.00%, N 2.45%; Found: C 58.79% H 7.85% N 2.41%. Example 52 (2S, 4S)-l-Dodecyl-4-f4-(3-oxo-4.4,4-trifluorobut-l-yl)phenoxylpyrrolidine- 2-propanoic acid, methyl ester (2S, 4SVl-N-Dodecyl-4-(4-iodophenoxy ' )pyrrolidine-2-methanol To a solution of (2S, 4S)-l-N-dodecyl-4-(4-iodophenoxy)pyrrolidine-2- carboxylic acid, methyl ester (2.09g, 4.06mmol) in tetrahydrofuran (20ml) at -78°C was added dropwise diisobutylaluminum hydride (1.0M in hexane, 15.0ml, 15.0mmol). After stirring at this temperature for 5min. and at 0°C for 2.5h, the reaction was quenched with water at 0°C. After stirring at r.t. for lOmin., the mixture was diluted with ethyl acetate (250ml), washed with 2N sodium hydroxide (3x100ml), 35% sodium and potassium tartrate (2x100ml), brine (100ml), dried over sodium sulfate and concentrated in vacuo. The residue was chromatographed on silica gel (hexane/ethyl acetate 3 : 1 to 2 : 1) to afford the title compound (1.65g, 79%) as a colorless oil. [a]D= -18.5° (c 0.92, CHCI3). Analysis for C23H38F3INO2 calcd. C 56.67%, H 7.86%, N 2.87%; Found: C 56.65% H 7.39% N 2.95%. (2S, 4SVl-N-Dodecyl-4-(4-iodophenoxy ' )pyrrolidine-2-propenoic acid, methyl ester To a solution of oxalyl chloride (1.1ml, 12.1mmol) in dichloromethane (17ml) at -60°C was added dropwise dimethylsufoxide (1.7ml, 24.2mmol). After stirring for 5min., a solution of (2S, 4S)-l-N-dodecyl-4-(4- iodophenoxy)- pyrrolidine-2-methanol (1.18g, 2.42mmol) in dichloromethane (6ml) was then added dropwise. The resulting mixture was stirred, and the temperature allowed to rise gradually to -20°C over a period of 2h. The reaction was quenched with sat. ammonium chloride, diluted with dichloromethane , washed three times with sat. ammonium chloride, brine and dried over sodium sulfate . The solvent was removed in vacuo to afford the corresponding aldehyde which was directly used in the next step. The above material was dissolved in dichloromethane (20ml) and treated with methyl (triphenyl-phosphoranylidene) acetate (1.44g, 4.3mmol). The mixture was stirred at 22°C for 22h and concentrated in vacuo. The residue was chromatographed on silica gel (hexane/ethyl acetate 15 :1 to 10 : 1) to afford E- (2 S, 4S)-l-N-Dodecyl-4-(4-iodophenoxy)pyrrolidine-2- propenoic acid , methyl ester (934mg, 61%) as a white solid [m.p. 60-61°C, [a]D= -42.2° (c 0.96, CDCI3)] and Z- (2 S, 4S)-l-N-dodecyl-4-(4- iodophenoxy)pyrrolidine-2-propenoic acid, methyl ester (149mg, 9%) as a clear oil. [a]o= -79.3 0 (c 1.24, CHCI3). Analysis for E-isomer C26H40INO3 calcd. C 57.67%, H 7.45%, N 2.59%; Found: C 57.41% H 7.50% N 2.64%. (2S. 4SVl-N-Dodecyl-4-[4-lEV[3-hydroxy-4.4.4-trifluorobut-l-en-l- yllphenoxy]pyrrolidine-2-propenoic acid, methyl ester (2S, 4S)-l-N-Dodecyl-4-(4-iodophenoxy)pyrrolidine-2-propenoic acid, methyl ester (677mg, 1.24mmol) and 4,4,4-trifluorobut-l-en-3-ol (complex with 1 tetrahydrofuran, 1.23g, 6.2mmol) were reacted by the general procedure as described in the preparation of 4-[N-dodecyl-N-2-[4-(E)-[3- hydroxy-4,4,4-trifluorobut-l-en-l-yl]phenoxy]ethylamino]butanoic acid, ethyl ester and afforded the title compound (250mg, 37%) as a colorless oil. Analysis for C30H44F3N O4 .2H2O calcd. C 66.32%, H 8.24%, N 2.58%; Found: C 66.14% H 8.03% N 2.55%. l » (2S. 4SVl-N-Dodecyl-4-i4-r3-hydroxy-4.4.4-trifluoro-l- butyl]phenoxy]pyrrolidine-2-propanoic acid, methyl ester (2S, 4S)-l-N-Dodecyl-4-[4-(E)-[3-hydroxy-4,4,4-trifluorobut-l-en-l- yl]phenoxy]pyrrolidine-2-propenoic acid, methyl ester (260mg., 0.482mmol) was hydrogenated as described in the preparation of 4-[N- dodecyl-N-2-[4-[3-hydroxy-4,4,4-trifluorobutyl]phenoxy] ethylamino]- butanoic acid, ethyl ester.and afforded the title compound (185mg, 71%) as a colorless oil. [a]D= -35.3° (c 0.85, CHCI3) Analysis for C30H48F3N O4 .IH2O calcd. C 66.05%, H 8.91%, N 2.57%; Found: C 65.89% H 8.68% N 2.51%. (2S. 4S -l-N-Dodecyl-4- 4-(3-oxo-4.4.4-trifluorobut-l- ylφhenoxy pyrrolidine-2-propanoic acid, methyl ester (2S, 4S)-l-N-Dodecyl-4-[4-[3-hydroxy-4,4,4- trifluorobutyl]phenoxy]pyrrolidine-2-propanoic acid, methyl ester (150mg, 0.276mmol) was oxidized as described in the preparation of 4-[N-dodecyl- N-[2-[4-(3-oxo-4,4,4-trifluorobut-l-yl)phenoxy]ethyl]amino]butanoic acid, ethyl ester and afforded the title compound (70mg, 47%) as a pale yellow oil. [a]D= -35.7 0 (c 0.84, CDCI3) Treatment of the above free amine with anhydrous hydrogen chloride (1.0 M in ether) gave the hydrochloride salt as a pale yellow foam. C30H46F3N O4ΗCM.IH2O calcd. C 60.26%, H 8.29%, N 2.34%; Found: C 60.29% H 8.10% N 2.34%. The following compounds may be prepared by the general procedure of Scheme 2. SCHEME 2 TABLE A (CH2) n R 1 ιt^\ \ Scheme 3 13 14 NaOhL. 15 ι.ς Example 60 N.N-Dimethyl-N-r2-r4-(3-oxo-4.4.4-trifluorobut-l-yl)-phenoxy1ethyn dodecyl- ammonium, iodide A solution of 4-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]phenyl]-l,l,l- trifluoro-2-butanone (250mg, 0.56mmol) in isopropanol (6ml) and methyl iodide (2ml) was heated to reflux for 0.5h. After cooling to r.t., the mixture was evaporated in vacuo and the last traces of isopropanol co-evaporated with dichloromethane to afford the title compound (327mg, 100%) as a yellow waxy solid. Analysis for C26H43F3INO2 .7H2O calcd. C 52.21%, H 7.48%, N 2.34%; Found: C 52.21%, H 7.43%, N 2.40%. Example 61 N.N-Dimethyl-N-r2-r3-(3-oxo-4.4.4-trifluorobut-l-yl)-phenoxylethyn dodecyl- ammonium, iodide 4-[3-[2-(N-Dodecyl-N-methylamino)ethoxy]phenyl]-l,l,l-trifluoro-2- butanone (300mg, 0.68mmol) was reacted by the general procedure as described in the preparation of N,N-dimethyl-N-[2-[4-(3-oxo4,4,4- trifluorobut-l-yl)-phenoxy]ethyl] dodecyl- ammonium, iodide and afforded the title compound (397mg, 100%) as a yellow syrup. Analysis for C26H43F3INO2 H2O calcd. C 51.74%, H 7.52%, N 2.32%; Found: C 51.90%, H 7.58%, N 2.32%. Example 62 N.N-Dimethyl-N-f2-l2-(3-oxo-4.4.4-trifluorobut-l-yl)-phenoxylethyn dodecyl- ammonium, iodide 4-[2-[2-(N-Dodecyl-N-methylamino)ethoxy]phenyl]-l,l,l-trifluoro-2- butanone (417mg, 0.94mmol) was reacted by the general procedure as described in the preparation of N,N-dimethyl-N-[2-[4-(3-oxo4,4,4- trifluorobut-l-yl)-phenoxy]ethyl] dodecyl- ammonium, iodide and afforded the title compound (550mg, 100%) as a yellow syrup. M =r Analysis for C26H43F3INO2 .5H2O calcd. C 52.53%, H 7.46%, N 2.36%; Found: C 52.46%, H 7.42%, N 2.42%. Example 63 N.N-Dimethyl-N-f2-f2-(trifluoroacetyl)phenoxy1ethyn dodecylammonium. iodide [2-[2-fN.N-Dimethylamino')ethoxy1phenyl]-2.2,2-trifluoroethanone A mixture of 2-trifluoroacetylphenol (380mg, 2.0mmol), 2-[N, N- dimethylamino]ethyl chloride, hydrochloride (432mg, ό.Ommol) potassium carbonate (1.38g, lOmmol) and toluene (5ml) was refluxed for 3.5h. After cooling to r.t., the mixture was treated with water and ether. The organic layer was washed twice with brine, dried over sodium sulfate and concentrated in vacuo . The residue was chromatographed on silica gel (acetone /ether 1 : 1 to 1 : 0) to give the title compound (375mg, 72%) as a white solid. N,N-Dimethyl-N-[2- 2-(trifluoroacetyDphenoxy]ethyl] dodecylammonium. iodide A mixture of [2-[2-(N,N-Dimethylamino)ethoxy]phenyl]-2,2,2- trifluoroethanone (416mg, 1.59mmol), 1-iodododecane (l-42g, 4.8mmol) and isopropanol (20ml) was refluxed for 24h. After cooling to r.t., the solvent was removed in vacuo. The residue was chromatographed on silica gel [dicloromethane /methanol /ammonium hydroxide (28%) 90 : 10 : 1 to 85 : 15 : 1] to give a pale yellow solid. Recrystallization from acetone/ether (1 : 3) afforded the title compound (512mg, 58%) as fine needles. Analysis for C24H39F3INO2 calcd. C 51.71%, H 7.05%, N 2.51%; Found: C 51.83%, H 7.07%, N 2.51%. Example 64 N.N-Dimethyl-N-[2-f2-(trifluoroacetyl)phenoxy1ethyn octadecylammonium. iodide [2-[2-(N,N-Dimethylamino)ethoxy]phenyl]-2,2,2-trifluoroethanone (400mg, 1.5mmol) and 1-iodooctadecane (1.8g, 4.8mmol) were reacted by the general procedure as described in the preparation of N,N-dimethyl-N- [2-[2-(trifluoroacetyl)phenoxy]ethyl] dodecylammonium, iodide. Recrystallization from Acetone/ether (1 : 2) afforded the title compound (500mg, 52%) as fine needles. Analysis for C30H51F3INO2 calcd. C 56.16%, H 8.01%, N 2.18%; Found: C 56.06%, H 7.90%, N 2.13%. Example 65 N f N-Dimethyl-N-[2-f4-(trifluoroacetyl)phenoxylethyn octadecylammonium, iodide N,N-Dimethyl-2-(4-bromophenoxy ethylamine A mixture of 4-bromophenol (5.0g, 28.9mmol), 2-(N, N- dimethylamino) ethyl chloride, hydrochloride (6.24g, 43.4mmol), sodium iodide (600mg, 4mmol), cesium carbonate (28g, 86.7mmol) and methyl ethyl ketone (120ml) was heated to reflux for 4h. After cooling to r.t., the mixture was filtered and washed with acetone. The combined filtrates were concentrated in vacuo, and the residue was chromatographed on silica gel (dichloromethane /methanol 95 : 5 to 90 : 10) to give a pale yellow liquid. Bulb-to-bulb distillation (80-84°C/0.05mmHg) afforded the title compound (5.19g, 74%) as a colorless liquid. [4-[2-(N,N-Dimethylamino)ethoxy]phenyl]-2,2,2-trifluoroethanone To a solution of N,N-dimethyl-2-(4-bromophenoxy)ethylamine (l.Og, 4.1mmol) in tetrahydrofuran (10ml) at -78°C was added dropwise n- butyllithium (1.5M in hexane, 2.7ml, 4.1mmol). The mixture was stirred at this temperature for 15min. and then transferred via a cannula into a pre-cooled solution of ethyl trifluoroacetate (0.64g, 4.5mmol) in ether (8ml) at -78°C. The resulting mixture was stirred and the temperature allowed to rise gradually to r.t. over a period of 1.5h. The reaction mixture was then quenched with water (5ml) and diluted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and concentrated in vacuo . Bulb-to-bulb distillation (82-84°C/0.01mmHg) afforded the title compound (423mg, 39%) as a pale yellow oil. Analysis for C12H14F3NO2 -0.3H2O calcd. C 54.05%, H 5.52%, N 5.25%; Found: C 54.12%, H 5.39%, N 5.28%. N.N-DimethyI-N-[2-[4-(trifluoroacetyDphenoxy]ethyl] octadecylammonium. iodide [4-[2-(N,N-Dimethylamino)ethoxy]phenyl]-2,2,2-trifluoroethanone (343mg, 1.31mmol) and 1-iodooctadecane (1.16g, 53.93mmol) were reacted by the general procedures as described in the preparation of N,N- dimethyl-N-[2-[2-(trifluoroacetyl)phenoxy]ethyl] dodecylammonium, iodide. The residue was chromatographed on silica gel [dichloromethane/methanol/ammonium hydroxide (28%) 98 : 2 : 0.5 to 90 : 10 : 1] to give the title compound (722mg, 86%) as a white solid. Analysis for C30H51F3INO2 calcd. C 56.16%, H 8.01%, N 2.18%; Found: C 56.33%, H 7.79%, N 2.09%. Example 66 N.N-Dimethyl-N-f2-f3-(trifluoroacetyl)phenoxy1ethyn octadecylammonium. iodide N,N-Dimethyl-2-(3-bromophenoxy ethylamine 3-Bromophenol (5.0g, 28.9mmol) and 2-(N, N-dimethylamino)ethyl chloride, hydrochloride (6.24g, 43.3mmol) were reacted by the general procedures as described in the preparation of N,N-dimethyl-2-(4- bromophenoxy)ethylamine. The residue was chromatographed on silica gel (dichloromethane /methanol 100 : 0 to 90 : 10) to give the title compound (5.2g, 74%) as a pale yellow liquid. \2d [S-fΣ-CN.N-Dimethylaminolethoxylpheny^-Σ.Σ.Σ-trifluoroethanone N,N-Dimethyl-2-(3-bromophenoxy)ethylamine (2.87g, 11.7mmol) and ethyl trifluoroacetate (2.5g, 17.6mmol) were reacted by the general procedure as described in the preparation of [4-[2-(N,N- dimethylamino)ethoxy]phenyl]-2,2,2-trifluoroethanone. The residue was distilled under reduced pressure to afford the title compound (1.34g, 44%) as a pale yellow liquid. Analytically pure sample was obtained by a second distillation under reduced pressure. Analysis for C12H14F3NO2 -0.8H2O calcd. C 52.29%, H 5.70%, N 5.08%; Found: C 52.61%, H 5.53%, N 4.96%. N.N-Dimethy1-N-[2-r3-ι / Trifluoroacetylφhenoxy1ethyl] octadecylammonium. iodide [3-[2-(N,N-Dimethylamino)ethoxy]phenyl]-2,2,2-trifluoroethanone (438mg, 1.67mmol) and 1-iodooctadecane (1.9g, 5.0mmol) were reacted by the general procedure as described in the preparation of N,N-dimethyl-N- [2-[2-(trifluoroacetyl)phenoxy]ethyl] dodecylammonium, iodide. Recrystallization from acetone/ether (1 : 2) afforded the title compound (530mg, 50%) as fine needles. Analysis for C30H51F3INO2O.2H2O calcd. C 55.84%, H 8.03%, N 2.17%; Found: C 55.79%, H 7.98%, N 2.10%. Example 67 N-r(Ethoxycarbonyl)methyn-N-r2-r4-(3-oxo-4.4.4-trifluorobut-l- yl)phenoxylethyll-N-(methyl)- dodecylammonium. iodide A solution of 4-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]phenyl]-l,l,l- trifluoro-2-butanone (620mg, 1.4mmol) and ethyl iodoacetate (0.5ml, 4.2mmol) in ethanol (20ml) was heated to reflux for 3h. After cooling to r.t., the mixture was concentrated in vacuo . The residue was chromatographed on silica gel [dichloromethane/methanol/ ammonium hydroxide (28%) 95 : 5 : 0.5 to 90 : 10 : 1] to give a colorless syrup. This material was dissolved in aqueous tetrahydrofuran (90%), evaporated in vacuo and co-evaporated with acetonitrile to afford the title compound (855mg, 93%) as a colorless syrup. 12.) Example 68 N-(Carboxymethyl)-N-f2-f4-(3-oxo-4,4,4-trifluorobut-l-yl)phenoxy1ethyll- N-(methyl)dodecyl ammonium, hydroxide, inner salt A solution of N-[(ethoxycarbonyl)methyl]-N-[2-[4-(3-oxo-4,4,4-trifluorobut- l-yl)phenoxy]ethyl]-N-(methyl)- dodecylammonium, iodide (617mg, 0.938mmol) in ethanol (95%, 20ml) was treated with potassium hydroxide (63mg, 1.12mmol). The mixture was stirred at 22°C for 3h, and then concentrated in vacuo. The residue was chromatographed on silica gel [dichloromethane/methanol/ ammonium hydroxide (28%) 90 : 10 : 1 to 85 : 15 : 1] to give a white solid. Recrystallization from ethanol-water (1 : 1) afforded the title compound (300mg, 64%) as fine needles. Analysis for C27H42F3NO4Η2O calcd. C 62.41%, H 8.54%, N 2.70%; Found: C 62.30%, H 8.70%, N 2.56%. Example 69 N.N-Dimethyl-N-r2-r2-benzyl-4-(3-oxo-4.4.4-trifluorobut-l- yDphenoxylethyll dodecyl- ammonium, iodide 4-[3-Benzyl-4-[2-(N-dodecyl-N-methylamino)ethoxy]phenyl]-l,l,l- trifluoro-2-butanone (180mg, 0.338mmol) was reacted by the general procedure as described in the preparation of N,N-dimethyl-N-[2-[4-(3-oxo- 4,4,4-trifluorobut-l-yl)-phenoxy]ethyl] dodecyl- ammonium, iodide and afforded the title compound (228mg, 100%) as a yellow syrup. Analysis for C33H49F3IN02-1.1H20 calcd. C 56.99%, H 7.42%, N 2.01%; Found: C 56.98%, H 7.25%, N 2.07%. Example 70 N-r(Ethoxycarbonyl)methyn-N-f2-f2-benzyl-4-(3-oxo-4.4,4-trifluorobut-l- yl)phenoxylethyn-N-(methyl)- dodecylammonium. iodide 4-[3-Benzyl-4-[2-(N-dodecyl-N-methylamino)ethoxy]phenyl]-l,l,l- trifluoro-2-butanone (340mg, 0.638mmol) was reacted by the general procedure as described in the preparation of N-[(ethoxycarbonyl)methyl]- ,2-Z N-[2-[4-(3-oxo-4,4,4-trifluorobut-l-yl)phenoxy]ethyl]-N-(methyl)- dodecylammonium, iodide and afforded the title compound (455mg, 93%) as a yellow waxy solid. Analysis for C36H53F3INO4 calcd. C 57.83%, H 7.14%, N 1.87%; Found: C 57.83%, H 7.56%, N 1.78%. Example 71 N-(Carboxymethyl)-N-f2-f2-benzyl-4-(3-oxo-4,4,4-trifluorobut-l- yl)phenoxylethyn-N-(methyl)dodecyl ammonium, hydroxide, inner salt N-[(Ethoxycarbonyl)methyl]-N-[2-[2-benzyl-4-(3-oxo-4,4,4-trifluorobut-l- yl)phenoxy]ethyl]-N-(methyl)- dodecylammonium, iodide (330mg, 0.442mmol) was saponified as described in the preparation of N- (carboxymethyl)-N-[2-[4-(3-oxo-4,4,4-trifluorobut-l-yl)phenoxy]ethyl]-N- (methyl)dodecyl ammonium, hydroxide, inner salt, and afforded the title compound (182mg, 70%) as a white foam. Analysis for C34H48F3NO4Η2O calcd. C 66.19%, H 8.30%, N 2.27%; Found: C 66.21%, H 8.15%, N 2.29%. Example 72 N-f(Ethoxycarbonyl)methyn-N-f2-[2-benzyl-4- (trifluoroacetyl)phenoxylethyn-N-(methyl)- dodecylammonium, iodide [3-Benzyl-4- [2-(N-dodecyl-N-methylamino)ethoxy jphenyl] -2,2,2- trifluoroethanone (2.81g, 5.56mmol) was reacted by the general procedure as described in the preparation of N-[(ethoxycarbonyl)methyl]-N-[2-[4-(3- oxo-4,4,4-trifluorobut-l-yl)phenoxy]ethyl]-N-(methyl)- dodecylammonium, iodide and afforded the title compound (2.1g, 52%) as a yellow solid. Analysis for C34H48F3INO4 calcd. C 56.75%, H 6.86%, N 1.95%; Found: C 57.14%, H 6.94%, N 2.05%. , 23 Example 73 N-(Carboxymethyl)-N-f2-f2-benzyl-4-(trifluoroacetyl)phenoxylethyn-N- (methyl)dodecyl ammonium, hydroxide, inner salt N-[(Ethoxycarbonyl)methyl]-N-[2-[2-benzyl-4- (trifluoroacetyl)phenoxy]ethyl]-N-(methyl)- dodecylammonium, iodide (500mg, 0.69mmol) was saponified as described in the preparation of N- (carboxymethyl)-N-[2-[4-(3-oxo-4,4,4-trifluorobut-l-yl)phenoxy]ethyl]-N- (methyl)dodecyl ammonium, hydroxide, inner salt, and afforded the title compound (259mg, 65%) as an off-white solid. Analysis for C32H44F3NO4 .7H2O calcd. C 66.69%, H 7.94%, N 2.43%; Found: C 66.63%, H 8.00%, N 2.42%. U Scheme 4 dichlo nR 2 23 22 ιz/ Example 74 4-rN-Dodecyl-N-r2-r4-(3-oxo-4,4.4-trifluorobut-l- yDphenoxylethynaminolbutanoic acid, ethyl ester Method II 4-[4-Methoxyphenyl]-l ,1 ,1-trifluoro— 2-butanone To a solution of 3-[4-methoxyphenyl]propionic acid (40.0g, 0.222mol) in dichloromethane (300ml) at 22°C was added slowly oxalyl chloride (29ml, 0.333mol). After stirring for 2.5h, the solvent and excess reagent were removed in vacuo . The residue was dissolved in dichloromethane (300ml), and was then added to a solution of trifluoroacetic anhydride (294ml, 0.666mol) in dichloromethane (300ml) at 0°C (ice bath). Pyridine (36ml, 0.444mol) was then added dropwise at 0°C , and the reaction mixture was stirred for 0.5h at which time the cooling bath was removed. After stirring at 22°C for 3h, the reaction was cooled again to 0°C and quenched with distilled water (100ml). The mixture was stirred at 22°C for lh, neutralized with solid sodium bicarbonate, diluted with dichloromethane (IL), washed with sat. aq. sodium bicarbonate (300ml), brine (300ml), dried over anhydrous magnesium sulfate and concentrated in vacuo. The residue was purified by bulb-to-bulb distilation (96-98°C, 0.2mmHg) to afford the title compound (43.5g, 84%) as a yellow liquid. Analysis for C11H11F3O2 calcd. C 56.90%, H 4.78%; Found: C 56.61% H 4.98%. 4-[4-Hydroxyphenyl]-l ,1 ,l-trifluoro-2-butanone To a solution of l,l,l-trifluoro-4-[4-methoxyphenyl]-2-butanone (43.5g, 0.187mol) in dichloromethane (500ml) at -78°C (dry ice-acetone) was added dropwise boron tribromide (53ml, 0.561mol). The mixture was then stirred at 0°C (ice bath) for 3h, and cautiously quenched by dropwise addition of ice-water (200ml) over a period of lh. The aqueous phase was saturated with solid sodium chloride, extracted with dichloromethane (500ml) followed by diethyl ether (500ml). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated in vacuo. The residue was purified by bulb-to-bulb distilation (96-100°C, 0.2mmHg) to afford the title compound (34.4g, 84%) as a yellow liquid which solidified upon standing. Analysis for C10H9F3O2 -0.5H2O calcd. C 52.87%, H 4.44%; Found: C 52.93% H 4.53%. 4-(3,3-Dimethoxy-4,4,4-trifluorobut-l-yl ' )phenol') To a solution of l,l,l-trifluoro-4-[4-hydroxyphenyl]-2-butanone (40.4g, 0.185mol) in nitromethane (300ml) were added methanol (40ml), trimethyl orthoformate (100ml) and trifluoromethanesulfonic acid (1ml). The resulting mixture was heated to 75°C for 20h, then cooled to r.t. and poured into sat. sodium bicarbonate (700ml). After stirring for lOmin., the mixture was extracted with ethyl acetate (2x2L). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated in vacuo. The residue was chromatographed on silica gel (dichloromethane/methanol 98 : 2 to 97 : 3) to afford the title compound (21.5g, 44%) as a yellow oil and l,l,l-trifluoro-4[4-hydroxyphenyl]-2- butanone (23g, 57%). Analytically pure sample (20.2g, 41%) of 4-(4,4,4- trifluoro-3,3-dimethoxybut-l-yl)phenol was obtained by bulb-to-bulb distilation (98-102°C, 0.02mmHg). r2-f4-(3.3-Dimethoxy-4,4,4-trifluorobut-l-yl)phenoxy ethyl] bromide A mixture of 4-(3,3-dimethoxy-4,4,4-trifluorobut-l-yl)phenol (1.64g, 6.2mmol), potassium carbonate (1.3g, 9.3mmol) and 1,2-dibromoethane (5ml, 58mmol) was stirred and heated under reflux (130°C) for 26h. After cooling to room temperature, the mixture was filtered and washed with ethyl actate. The filtrate was concentrated in vacuo and the residue was purified by column chromatography (silica gel, hexane/ethyl acetate 20 : 1 to 4 : 1) to give the title compound (2.0g, 85%) as a colorless liquid. Analysis for Ci Hi8B r F3θ3 calcd. C 45.30%, H 4.89%; Found: C 45.57% H 4.72%. ill N-[2-[4-( / 3.3-Dimethoxy-4.4.4-trifluorobut-l- yl)phenoxy]ethyl]dodecanamine A mixture of 4-[4-(2-bromoethoxy)phenyl]-l,l,l-trifluoro-2-butanone, dimethyl ketal (5.0g, 13.5mmol), dodecylamine (12.5g 67.4mmol), disopropylethylamine (7.0ml, 40.4mmol), Nal (2.0g, 13.5mmol) and isopropanol(lθθml) was stirred and heated under reflux for 16h. After cooling to room temperature, the mixture was concentrated in vacuo, diluted with ethyl acetate (300ml), washed with brine (100ml), dried over anhydrous magnesium sulfate and concentrated in vacuo. The residue was chromatographed on silica gel (dichloromethane/methanol 98 : 2 to 96 : 4) to afford the title compound (5.3g, 83%) as a colorless syrup. Treatment of the above free amine with anhydrous hydrogen chloride (1.0 M in ether) gave the hydrochloride salt as a white solid. Analysis for C26H44F3N O3ΗCI calcd. C 60.98%, H 8.86%, N 2.74%; Found: C 60.73% H 8.56% N 2.73%. 4-rN-Dodecyl-N-[2-[4-(3.3-Dimethoxy-4.4.4-trifluorobut-l- v phenoxy] ethyl] aminolbutanoic acid, ethyl ester A solution of N-[2-[4-(3,3-dimethoxy-4,4,4-trifluorobut-l-yl)phenoxy]- ethyl]dodecanamine (2.0g, 4.2mmol) in methanol (50ml) was treated with sodium cyanoborohydride (0.55g, 8.4mmol) and ethyl 4-oxobutyrate (1.04g, 8.4mmol). The resulting mixture was stirred at 22°C for 16h, diluted with diethyl ether (350ml), washed with water (200ml), brine (200ml), dried over magnesium sulfate and concentrated in vacuo . The residue was chromatographed on silica gel (hexane /AcOEt 9 : 1 to 6 : 1) to afford the title compound (1.8g, 73%) as a liquid. Analysis for C32H54F3N O5 -0.3H2O calcd. C 64.58%, H 9.25%, N 2.35%; Found: C 64.54% H 9.02% N 2.39%. 4-rN-Dodecyl-N-[2-[4-(3-oxo-4.4.4-trifluorobut-l- v phenoxy] ethyl] amino]butanoic acid, ethyl ester A solution of 4-[N-Dodecyl-N-[2-[4-(3,3-dimethoxy-4,4,4-trifluorobut-l- yl)phenoxy]ethyl]amino]- butanoic acid, ethyl ester (315mg, 0.53mmol) in trifluoroacetic acid (5ml) was heated to 70°C for 2h, and then concentrated \2 in vacuo . The residue was diluted with ethyl acetate (100ml), washed with sat. sodium bicarbonate (30ml), brine (30ml), dried over magnesium sulfate and concentrated in vacuo . The residue was chromatographed on silica gel (Hexane/ethyl acetate 2 : 1 to 1.5 : 1) to afford the title compound (224mg, 77%) as a colorless oil. The following compounds may be prepared by the general procedure of Scheme 4. ,2^ SCHEME 4 Table (CH2) n R \^ V"Λ Scheme 5 Example 84 4-r4-r2-(N-Dodecyl-N-propylaminolethoxylphenyn-l,l,l-trifluoro-2- butanone N-Propyl-N-[2-[4-C3.3-dimethoxy-4.4.4-trifluorobut-l- y phenoxy] ethyl] dodecy lamine A solution of N-[2-[4-(3,3-dimethoxy-4,4,4-trifluorobut-l- yl)phenoxy]ethyl]dodecylamine (500mg, 1.05mmol), diisopropyl ethylamine (0.35ml, 2.1mmol) and 1-iodopropane (0.26ml, 2.66mmol) in isopropanol was heated to reflux for 21 h. After cooling to r.t., the mixture was diluted with ethyl acetate and filtered. The filtrate was concentrated in vacuo , and the residue was chromatographed on silica gel (dichloromethane/methanol 98 : 2 to 95 : 5) to afford the title compound (0.526g, 73%) as a colorless oil. 4-[4-[2-(N-Dodecyl-N-propylamino]ethoxy]phenyl]-l,l,l-trifluoro-2- butanone N-Propyl-N-[2-[4-(4,4,4-trifluoro-3,3-dimethoxybut-l- yl)phenoxy]ethyl]dodecylamine (300mg, 0.58mmol) was treated with trifluoroacetic acid as described in the preparation of 4-[N-dodecyl-N-[2-[4- (4,4,4-trif luoro-3-oxobut-l -y l)phenoxy ] ethyl] amino]butanoic acid, ethyl ester and afforded the title compound (169mg, 62%) as a pale yellow oil. Analysis for C27H44F3NO2O.9H2O calcd. C 66.47%, H 9.46%, N 2.87%; Found: C 66.39%, H 9.10%, N 2.87%. Treatment of the above free amine with anhydrous hydrogen chloride (1.0 M in ether) gave the hydrochloride salt as a pale yellow syrup. Analysis for C27H44F3NO2ΗCM.2H2O calcd. C 61.22%, H 9.02%, N 2.64%; Found: C 61.38%, H 8.61%, N 2.75%. I 3 Example 85 4-f4-r2-(N-Dodecyl-N-hexylamino1ethoxy1phenyll-l,l,l-trifluoro-2- butanone N-Hexyl-N-r2-r4-t / 3.3-dimethoxy-4.4.4-trifluorobut-l- v phenoxy] ethyl] dodecylamine N-[2-[4-(3,3-Dimethoxy-4,4,4-trifluorobut-l- yl)phenoxy] ethyl] dodecylamine (500mg, 1.05mmol) and 1-iodohexane (0.186ml, 1.26mmol) were reacted as described in the preparation of N- propyl-N-[2-[4-(3,3-dimethoxy-4,4,4-trifluorobut-l- yl)phenoxy] ethyl] dodecylamine and afforded the title compound (390mg, g, 67%) as a liquid. 4-[4-[2-( , N-Dodecyl-N-Hexylamino]ethoxy]phenyl1-l,l,l-trifluoro-2- butanone N-Hexyl-N-[2-[4-(3,3-dimethoxy-4,4,4-trifluorobut-l- yl)phenoxy] ethyl] dodecylamine (353mg, 0.63mmol) was treated with trifluoroacetic acid as described in the preparation of 4-[N-dodecyl-N-[2-[4- (4,4,4-trifluoro-3-oxobut-l-yl)phenoxy]ethyl]amino]butanoic acid, ethyl ester . The residue was chromatographed on silica gel (dichloromethane/methanol 98 : 2 to 94 : 6) to afford the title compound (253mg, 78%) as a pale yellow oil. Analysis for C30H50F3NO2 calcd. C 70.14%, H 9.81%, N 2.73%; Found: C 69.79%, H 9.82%, N 2.76%. Treatment of the above free amine with anhydrous hydrogen chloride (1.0 M in ether) gave the hydrochloride salt as a pale yellow syrup. Analysis for C30H50F3NO2ΗCIO.7H2O calcd. C 64.02%, H 9.39%, N 2.49%; Found: C 64.09%, H 9.05%, N 2.61%. U M Scheme 6 27 Example 86 4-f4-r2-(N-dodecyl-N-ethylamino1ethoxy1phenyn-l,l,l-trifluoro-2- butanone 2-[N-Dodecyl-N-ethylamino]ethanol 2-[Dodecylamino]ethanol (2.0g, 8.73 mmol) ,1-iodoethane (1.63g, 10.48 mmol) and N,N-diisopropylethylamine ( 2.51 g,l 7.5 mmol) in isopropanol ( 25 ml )were heated under reflux for 4 h. The solvent was then evaporated in vacuo and the residue was diluted with ethyl acetate washed with aqueous sodium bicarbonate, brine and dried (magnesium sulfate ). Evaporation of the solvent followed by chromatography on silica gel (ethyl acetate /methanol 90 : 10 to 80 : 20) afforded the title compound (1.65g, 73%) as a white solid. N-Ethy 1-N-r 2- f4-f 3.3-dimethoxy-4.4.4-trifluoro-but-l - y phenoxy ] ethyl] dod ecy lamine 2-[N-Dodecyl-N-ethylamino]ethanol (250mg, 0.96mmol) and 4-(3,3- dimethoxy-4,4,4-trifluorobut-l-yl)phenol (230mg, 0.87mmol) were reacted under Mitsunobu conditions as described in the preparation of 3-[4-[2-(N- dodecyl-N-methylamino)ethoxy]phenyl]propanoic acid, methyl ester. The usual work-up followed by chromatography on silica gel (Hexane/ethyl acetate 95 : 5 to 80 : 20) afforded the title compound (200mg, 46%) as a colorless oil. 4-[4-r2-(N-dodecyl-N-ethylamino]ethoxy1phenyl]-l,l,l-trifluoro-2- butanone N-Ethyl-N-[2-[4-(3,3-dimethoxy-4,4,4-trifluorobut-l- yl)phenoxy]ethyl]dodecylamine (123mg, 0.244mmol) was treated with trifluoroacetic acid as described in the preparation of 4-[N-dodecyl-N-[2-[4- (4,4,4-trifluoro-3-oxobut-l-yl)phenoxy]ethyl]amino]butanoic acid, ethyl ester and afforded the title compound (60mg, 54%) as a pale yellow oil. Treatment of the above free amine with anhydrous hydrogen chloride (1.0 M in ether) gave the hydrochloride salt as a pale yellow syrup. Analysis for C26H42F3NO2-HC1-0.6H2O calcd. C 60.45%, H 8.64%, N 2.69%; Found: C 60.19%, H 8.27%, N 3.08%. The following compounds may be prepared by the general procedure of Scheme 6. ~ SCHEME 6 Tables f SCHEME 6 - Table (continued) W i HI 10 15 20 IH3 Scheme 7 28 29 30 31 32 TFA 33a 33b Example 119 N-r2-f4-(4.4,4-trifluoro-3-oxo-l-butyl)phenoxy1ethyn-N-methyl dodecanamide N-[2-(4-formylphenoxy)ethyl]-N-methylcarbamic acid, 1,1-dimethylethyl ester A solution of N-(2-hydroxyethyl)-N-methylcarbamic acid, 1,1- dimethylethyl ester (7.05 g, 40.2 mmol; W.S. Saari and all, J. Med. Chem. 33, 97 (1990)), 4-hydroxybenzaldehyde (3.75 g, 30.7 mmol) and triphenylphosphine (10.57 g, 40.3 mmol) in dry benzene (120 ml) was cooled to 15°C and treated with diisopropyl azodicarboxylate (8.15 g, 40.3 mmol) in dry benzene (20 ml) added dropwise over 20 min. After 16 h at 22°C, and chromatography on silica gel (elution toluene-ethyl acetate 9:1- 8:2) gave 4.40 g (52%) of the title material as white cubes: mp 62-65°C (ether-hexane). Anal. Calcd. for C15H21NO4: C 64.50, H 7.58, N 5.01. Found: C 64.25, H 7.59, N 5.00. E-N-f2-f4-(4-trifluoro-3-oxo-l-butenyl)phenoxy1ethyn-N-methylcarbamic acid, 1,1-dimethylethyl ester A solution of N-[2-(4-formylphenoxy)ethyl]-N-methylcarbamic acid, 1,1- dimethylethyl ester (3.72 g, 13.3 mmol) in dry tetrahydrofuran (65 ml) was cooled to 10°C and treated with acetic acid (1.4 ml) and piperidine (1.4 ml). Then 1,1,1-trifluoroacetone (7 ml) in dry tetrahydrofuran was added dropwise over 10 min. After 2 h and 4 h at 20°C, two other successive portions of 1,1,1-trifluoromethylacetone (2 x 7 ml) were also added. After another 2 h at 22°C, the reaction mixture was diluted with ethyl acetate (300 ml) washed with water, saturated ammonium chloride, saturated sodium bicarbonate and brine. The organic phase was then dried, concentrated and chromatographed on silica gel. Elution with a gradient of ethyl acetate in hexane (0 - 20%) gave 3.05 g (61%) of the title material as yellow crystals: mp 76-77°C (hexane). Anal. Calcd. for C18H22NO4F3: C 57.90, H 5.94, N 3.75. Found: C 57.82, H 5.92, N 3.72. N-f2-f4-(4-trifluoro-3-oxo-l-butyl)phenoxylethyn-N-methylcarbamic acid, 1,1-dimethylethyl ester A solution of (E)-N-[2-[4-(4-trifluoro-3-oxo-l-butenyl)phenoxy]ethyl]-N- methylcarbamic acid, 1,1-dimethylethyl ester (1.10 g, 2.95 mmol) in ethyl acetate (80 ml) was hydrogenated at atmospheric pressure over 5% palladium on barium sulfate (0.20 g) for 1 hour. The catalyst was then filtered and the filtrate was concentrated under reduced pressure. The residue was dissolved in dichloromethane (60 ml) and then treated at 22°C with Dess-Martin periodinane reagent (2.50 g, 5.90 mmol). After 1 hour, the reaction mixture was diluted with ethyl acetate, washed with 10% aqueous sodium thiosulfate and saturated sodium bicarbonate. After drying, the organic phase was concentrated and chromatographed on silica gel. Elution with a gradient of ethyl acetate (0 - 10%) in toluene gave 0.880 g (79%) of the title material as an amorphous solid. By 'H NMR this product is a mixture of ketone and hydrated ketone. Anal. Calcd. for C18H24NO4F3. 0.7 H2O: C 55.72, H 6.60, N 3.61. Found: C 55.80, H 6.52, N 3.52. N-f2-r4-(4-trifluoro-3-oxo-l-butyl)phenoxylethyll-N-methyldodecanamide A solution of N-[2-[4-(4-trifluoro-3-oxo-l-butyl)phenoxy]ethyl]-N- methylcarbamic acid, 1,1-dimethylethyl ester (0.200 g, 0.53 mmol) in dichloromethane (10 ml) was treated with trifluoroacetic acid (1 ml) and stirred at 22°C for 1 h. The solvent was evaporated in vacuo and the residue was co-evaporated with toluene three times. The product was then dissolved in tetrahydrofuran (10 ml) treated with 40% sodium acetate in water (10 ml) and while stirred vigorously treated with lauroyl chloride (0.116 g, 0.53 g mmol) added dropwise over 2 min. After 1 hour at 22°C, the reaction mixture was diluted with ethyl acetate (150 ml), washed with water, saturated sodium bicarbonate and brine. After drying (magnesium sulfate) the solvent was evaporated in vacuo and the residue was chromatographed on silica gel. Elution with a gradient of ethyl acetate (0 - 30%) in toluene gave 0.181 g (74%) of the title material as a waxy solid. By Η NMR, this product is a mixture of ketone and hydrated ketone. Anal. Calcd. for C25H38F3NO3. H2O: C 63.14, H 8.48, N 2.95. Found: C 63.26, H 8.03, N 2.87. The following compounds may be prepared by the general procedure of Scheme 7. m SCHEME 7 M^ SCHEME 7 (continued) |S& Scheme 8 BrCH C0 tBu BrCH 2 C0 2 tBu acetone acetone potassium carbonate potassium carbonate (or R 2 COCI) 3Z 3S 39 ' ■ ^t 36 40 TFA dichloromethane 41 23 Example 133 N-Dodecyl-4-(4,4,4-trifluoro-3-oxo-l-butyl)phenoxyacetamide (E)-l ,1 ,l-trifluoro-4-(4-hydroxyphenyP-3-buten-2-one A solution of 4-hydroxybenzaldehyde (5.0 g, 40.9 mmol) in tetrahydrofuran (165 ml) was treated with acetic acid (3.5 ml) and piperidine (3.5 ml). Then 1,1,1-trifluoroacetone (8 ml) was added dropwise. After 2 h at 22°C, another portion of 1,1,1-trifluoroacetone (8 ml) was added and the mixture was stirred for another 3 h. The reaction mixture was then diluted with ethyl acetate, washed with water, saturated ammonium chloride, saturated sodium bicarbonate, and brine. The organic phase was dried (magnesium sulfate), concentrated under reduced pressure and chromatographed on silica gel. Elution with a gradient of ethyl acetate (0 - 5%) in toluene gave 4.16 g (47%) of title material as yellow needles after crystallization from ether-hexane: mp 106- 107°C. Anal. Calcd. for C10H7F3O2: C 55.57, H 3.26. Found: C 55.30, H 3.27. (E -4-(4,4,4-trifluoro-3-oxo-l-butenyl)phenoxyacetic acid, 1,1-dimethylethyl ester A solution of (E)-l,l,l-trifluoro-4-(4-hydroxyphenyl) 3-buten-2-one (0.105 g, 0.49 mmol) in acetone (6 ml) was treated with powdered potassium carbonate (0.3 g) and tert-butyl bromoacetate (0.20 g, 1.02 mmol) and stirred at 22°C for 3 h. The reaction mixture was then diluted with toluene, washed with brine, dried (magnesium sulfate) and concentrated under reduced pressure. The residue was chromatographed on silica gel (elution toluene-ethyl acetate 2%) and gave 0.150 g (94%) of the title material as yellow needles: mp 112-113°C. Anal. Calcd. for C16H17F3O4: C 58.18, H 5.19. Found: C 58.12, H 5.18. (E)-4-('4.4,4-trifluoro-3-oxo-l-butenyl)phenoxyacetic acid A solution of (E)-4-(4,4,4-trifluoro-3-oxo-l-butenyl)phenoxyacetic acid, 1,1- dimethylethyl ester (1.578 g, 4.77 mmol) in dichloromethane (90 ml) was treated with trifluoroacetic acid (10 ml) and stirred at 22°C for 4 h. The solvent and excess reagent were evaporated under reduced pressure and the last traces of trifluoroacetic acid were co-evaporated with toluene. Crystallization of the residue from ethyl acetate-hexane gave 1.29 g (98%) of the title material as white cubes: mp 156-156.5°C. Anal. Calcd. for C12H9F3O4: C 52.57, H 3.31. Found: C 52.66, H 3.29. ( E N-dodecyl-4-(4,4,4-trifluoro-3-oxo-l-butenyDphenoxyacetamide A solution of (E)-4-(4,4,4-trifluoro-3-oxo-l-butenyl)phenoxyacetic acid (0.810 g, 2.95 mmol) in tetrahydrofuran (20 ml) was treated with EEDQ (0.767 g, 3.10 mmol) and dodecylamine (0.575 g, 3.10 mmol). After 2 h at 22°C, the reaction mixture was diluted with ethyl acetate, washed with water, 0.1N hydrochloric acid, saturated sodium bicarbonate, brine and dried. Evaporation of the solvent under reduced pressure gave a solid which was chromatographed on silica gel. Elution with a mixture of toluene and ethyl acetate (8:12) gave 0.750 g (58%) of the title material as white needles after recrystallization from ethyl acetate-hexane: mp 78.5- 79°C. Anal. Calcd. for C24H34F3NO3: C 65.29, H 7.76, N 3.17. Found: C 65.30, H 7.73, N 3.13. N-dodecyl-4-(4.4,4-trifluoro-3-oxo-l-butyl)phenoxyacetamide (E)-N-dodecyl-4-(4,4,4-trifluoro-3-oxo-l-butenyl)phenoxyacetamide (0.530 g, 1.20 mmol) was hydrogenated and re-oxidized as described in example 119 to give 0.490 g (92%) of the title material as an amorphous solid. Anal. Calcd. for C24H36F3NO3H2O: C 62.45, H 8.30, N 3.03. Found: C 62.54, H 8.19, N 3.18. I Example 134 N-rBis-(4-chlorophenyl)methyl1-4-(4,4,4-trifluoro-3-oxo-l-butyl)- phenoxyacetamide 4-(4.4,4-trifluoro-3-oxo-l-butyl)-phenoxyacetacetic acid. 1 ,1-dimethylethyl ester E-(4,4,4-trifluoro-3-oxo-l-butenyl)-phenoxyacetacetic acid, 1,1- dimethylethyl ester (1.95 g, 5.90 mmol) was hydrogenated and re-oxidized as described in example 133 to give 1.93 g (98%) of the title material as a wax. Anal. Calcd. for C16H19F3O4: C 55.43, H 5.99. Found: C 55.32, H 5.90. 4-(4.4,4-trifluoro-3-oxo-l-butyl ' )phenoxyacetic acid 4-(4,4,4-trifluoro-3-oxo-l-butyl)phenoxyacetic acid 1,1-dimethylethyl ester (0.450 g, 1.35 mmol) was treated with trifluoroacetic acid as described in example (133) to give 0.373 g (100%) of the material as a white solid. N-[Bis-(4-chloropheny methyl]-4-C4.4.4-trifluoro-3-oxo-l- butyDphenoxyacetamide A solution of 4-(4,4,4-trifluoro-3-oxo-l-butyl)phenoxyacetic acid (0.374 g, 1.35 mmol) in dichloromethane (10 ml) was treated with oxalyl chloride (0.17 ml, 2.03 mmol) and a trace of N,N-dimethylformamide. After 30 min at 22°C, the solvent and excess reagent were evaporated under reduced pressure and the residual oil obtained was dissolved in anhydrous tetrahydrofuran (10 ml). This solution was then added dropwise to a vigorously stirred solution of p-chlorobenzhydrylamine hydrochloride (0.39 g, 1.35 mmol) in a mixture of tetrahydrofuran (10 ml) and 40% aqueous sodium acetate (10 ml). After 30 min at 22°C, the reaction mixture was diluted with ethyl acetate, washed with water, brine and dried. Evaporation of the solvent under reduced pressure gave a solid which was chromatographed on silica gel. Elution with a mixture of toluene and ethyl acetate (8:2) gave 0.603 g (87%) of the title product as white crystals: mp 145-146°C. Anal. Calcd. for C25H20CIF3NO3: C 58.84, H 3.85, N 2.74, CI 13.89, F 11.17. Found: C 58.73, H 4.07, N 2.82, CI 13.60, F 10.46. liTfo Scheme 9 CH 3 (CH 2 ) n SH + BrCH 2 CH 2 OH (CH 3 )(CH 2 ) n SCH 2 CH 2 OH DMF potassium carbonate 42 44 mCPBA . Nal0 4 dichloromethane methanol 0 q y O V S(CH 2 ) n CH 3 S(CH 2 ) n CH 3 Example 135 4-f4-r2-(Dodecylthio)ethoxyphenyn-l r 1 -tιifluoro-2-butanone 2-(Oodecyrthio^ Ethanol A mixture of 2-bromoethanol (6.08 g, 48.7 mmol), dodecanethiol (9.86 g, 48.7 mmol) and potassium carbonate (11 g) in dry N,N- dimethylformamide (100 ml) was stirred at 22°C for 10 h. The reaction mixture was then diluted with toluene (400 ml) washed with water and dried (magnesium sulfate). The solvent was evaporated under reduced pressure and the residue was filtered through a silica gel pad (toluene - ethyl acetate 95:5) and distilled under vacuum to give 9.18 g (77%) of 2- (dodecylthio)ethanol as a clear oil which solidified on standing: b.p. 100- 105°C/0,01 torr (bulb to bulb distillation, air bath temperature); m.p. 31- 32°C. IR (NaCl, film) μ^ (cm -1 ) : 3380 (OH). NMR 400 MHz (CDCI3) d (ppm) : 0.89 (3H, t, J=6.8 Hz, CH3), 1.2-1.7 (20H, m, (CH2)10), 2.16 (IH, br t, OH), 2.52 (2H, t, J=7.4 H, SCH2), 2.74 (2H, t, J=6.0 Hz, OCH2CH2S), 3.7 (2H, q, J=6.0 Hz, OCH2CH2S. Anal. Calcd. for C14H30OS: C 68.23, H 12.27, N 13.01. Found: C 68.06, H 12.29, N 12.95. 3-[4-[2-(Dodecylthio)ethoxy]phenyl]propanoic acid methyl ester A solution of methyl 3-[4-hydroxyphenyl)propionate (2.46 g, 13.6 mmol), 2-(dodecylthio)ethanol (3.40 g, 13.7 mmol) and triphenylphosphine (3.60 g, 13.8 mmol) in dry benzene (50 ml) was treated at 22°C with diethyl azodicarboxylate (2.43 g, 13.9 mmol) added dropwise over 10 min. After 3 h at 22°C, the reaction mixture was diluted with ethyl acetate, washed with water, brine and dried (magnesium sulfate). Evaporation under reduced pressure gave an oil which was triturated with hexane to precipitate the triphenylphosphine oxide and the hydrazine side products. The filtrate was chromatographed on silica gel using a gradient of ethyl acetate (0-5%) in hexane as eluent to give 4.70 g(84%) of 3-[4-[2- (dodecylthio)ethoxy]phenyl]propanoic acid methyl ester as a white solid. Recrystallization from methanol gives white leaflets : m.p. 48°C. IR (KBr) μ^ (cm -1 ) : 1729 (C=0 of ester). 1 H NMR 400 MHz (CDCI3) d (ppm) : 0.89 (3H, t, J=6.8 Hz, CH3), 1.2-1.7 (20H, m, (CH2)10), 2.6 (4H, br t, SCH2 and CH2CO), 2.9 (4H, br t, OCH2CH2S and PhCH?), 3.68 (3H, s, OCH3), 4.11 (2H, t, J=7.03 Hz, OCH2CH2S), 6.83 (2H, d, J=8.7 Hz aromatic), 7.12 (2H, d, J=8.7 Hz, aromatic). Anal. Calc. for C24H40O3S: C 70.54, H 9.87, S 7.85. Found: C 70.25, H 9,38, S 7.87. 3-[4-[2-(Oodecylthio')ethoxy]phenyl]propanoic acid H 2 )ι ι CH 3 (CH 2 )^ 1 CH 3 A suspension of 2-[4-[2-(dodecylthio)ethoxy]phenyl]propanoic acid methyl ester (4.70 g, 11.5 mmol) in 80% ethanol (100 ml) was treated with a solution of potassium hydroxide (1.33 g, 20.1 mmol) in water (10 ml) and the mixture was stirred at 55°C for 1 h. The solvent was then concentrated in vacuo and the residue was diluted with water (100 ml) and dichloromethane (250 ml). The solution was then adjusted to pH 2 with diluted hydrochloric acid and the aqueous phase was extracted a second time with dichloromethane. The combined organic extracts were washed with brine and dried (magnesium sulfate). Evaporation of the solvent under reduced pressure and crystallization of the residue from ethyl acetate-hexane gave 3.56 g (78%) of 3-[4-[2- (dodecylthio)ethoxy]phenyl]propanoic acid as white prisms: m.p. 68-69°C. IR (NaCl, film) μ maχ (cm -1 ) : 1710 (C=0). X H NMR 400 MHz (CDCI3) d (ppm) : 0.89 (3H, t, J=6.8 Hz, -CH3), 1.1-1.7 (20H, m, (CH2)10), 2.63 (4H, m, SCH2 and CH2CO), 2.90, (4H, m, OCH2CH2S and PhCH?). 4.12 (2H, t, J=6.99, OCH2CH2S), 6.84 (2H, d, J=8.5 Hz, aromatic), 7.13 (2H, d, J=8.5 Hz, aromatic). Anal, calcd. for C23H38O3S . 0.1 H2O: C 69.69, H 9.71, S 8.09. Found: C 69.55, H 9.86, S 8.15. 4-[4-[2-(Dodecyrthio')ethoxy]phenyl]-l ,1 ,l-trifluoro-2-butanone A solution of 3-[4-[2-(dodecylthio)ethoxy]phenyl]propanoic acid (14.13 g, 35.8 mmol) in dichloromethane (400 ml) was treated with oxalyl chloride (6.5 ml) and a drop of N,N-dimethylformamide and the resulting mixture was stirred at 22°C for 1 h. The solvent and excess reagent were evaporated under reduced pressure and the residue was dissolved in dry dichloromethane (200 ml). This solution was added to a cold (0°C) solution of trifluoroacetic anhydride (19.2 ml, 0.107 mol) in dichloromethane (200 ml). Then pyridine (6.1 ml, 75.4 mmol) was added dropwise and the resulting solution was stirred at 0°C for 30 min and then at 22°C for 2 h. Water (50 ml) was added and the mixture was stirred for another 30 min. The organic phase was then washed with brine, dried and concentrated under reduced pressure. Chromatography on silica gel (elution with a gradient of ethyl acetate 0-10% in toluene) gave 10.50 g (66%) of 4-[4-[2-(dodecylthio)ethoxy]phenyl]-l,l,l-trifluoro-2-butanone as an amorphous solid. IR (NaCl, film) μ^ (cm -1 ) : 1758 (C=0). *H NMR 400 MHz (CDCI3) d (ppm) : 0.89 (3H, t, J=6.8 Hz, -CH3), 1.2-1.7 (20H, m, (CH2)10), 2.62 (2H, t, J=7.46 Hz, SCH2), 2.89 (2H, t, J=6.95 Hz, OCH2QI2S), 2.9-3.1 (4H, m, CH9CH9CO).4.12 (2H, t, J=6.95 Hz, OCH2CH2S), 6.85 (2H, d, J=8.7 Hz, aromatic), 7.11 (2H, d, J=8.7 Hz, aromatic). Anal. Calcd. for C24H37F3O2S: C 64.54, H 8.35. Found: C 64.47, H 8.32. Example 136 4-[4-[2-(Dodecylsulfiny ethoxy]phenyl]-l.l,l-trifluoro-2-butanone A solution of 4-[4-[2-(dodecylthio)ethoxy]phenyl]-l,l,l-trifluoro-2- butanone (0.340 g, 0.76 mmol) in methanol (15 ml) was treated with a solution of sodium periodate (0.165 g, 0.77 mmol) in water (3 ml) and the resulting mixture was stirred at 22°C for 18 h. The solid formed was filtered and washed with methanol. This filtrate was then concentrated under reduced pressure and then partitioned between water and ethyl acetate. The organic phase was then dried (magnesium sulfate) and concentrated. The residue was chromatographed on silica gel (elution toluene-ethyl acetate 1:1) to give 0.335 g (90%) of 4-[4-[2- (dodecylsulfinyl)ethoxy]phenyl]-l,l,l-trifluoro-2-butanone as a white solid. By 'HNMR this product was a 6:4 mixture of trifluoromethyl ketone and hydrated trifluoromethyl ketone. The pure hydrate precipitates from ethyl acetate-hexane: m.p. 98-100°C. IR (NaCl, film) μ (cm -1 ) : 3400 (OH), 1650. iCl *H NMR 400 MHz (CDCI3) d (ppm) : 0.89 (3H, t, J=6.8 Hz, -CH3), 1.3, 1.45 and 1.8 (16H, 2H and 2N, 3m, (CH2)lθ), 2.09 (2H, br t, J=8 Hz, CH2CH2CO), 3.7 (2H, br, OH), 4.4 (2H, m, OCH2), 6.84 (2H, d, J=8.5 Hz, aromatic), 7.15 (2H, d, J=8.5 Hz, aromatic). Anal. Calcd. for C24H37F3S.H2O: C 59.98, H 8.18, S 6.67. Found: C 60.06, H 8.17, S 6.67. Example 137 4-[4-[2-(Dodecylsulfony ethoxy]phenyl]-l,l.l-trifluoro-2-butanone A solution of 4-[4-[2-(dodecylthio)ethoxy]phenyl]-l,l,l-trifluoro-2- butanone (0.394 g, 0.88 mmol) in dichloromethane (25 ml) was treated at 22°C with 85% m-chloroperbenzoic acid (0.40 g, 1.8 mmol) and the resulting mixture was stirred for 2.5 h. The reaction mixture was then washed with aqueous sodium bicarbonate, brine and dried (magnesium sulfate). Evaporation and chromatography on silica gel (elution with a gradient of ethyl acetate 0-20% in toluene) gave 0.344 g (82%) of 4-[4-[2- (dodecylsulfonyl)ethoxy]phenyl]-l,l,l-trifluorobutanone as an amorphous solid. By 'HNMR, this product is a -1:1 mixture of trifluoromethylketone and hydrated trifluoromethyl ketone: m.p. 55-56°C IR (NaCl, film) u max (cm "1 ) : 3400 (OH) and 1760 (C=0). H NMR 400 MHz (CDCI3) . Ketone form : d (ppm) : 0.89 (3H, t, J=6.8 Hz, -CH3), 1.28, 1.45 and 1.9 (16H, 2H and 2H, 3 m, (CH2)lθ), 3.0 (4H, m, CH9CH9CO . 3.12 (2H, m, Sθ9CH? 3.4 (2H, t, J=5.35 Hz, OCH2CH2S), 4.41 (2H, t, J=5.35 Hz, OCU2CH2S), 6.84 (2H, d, J=8.6 Hz, aromatic), 7.15 (2H, d, J=8.6 Hz, aromatic). Hydrate form : d (ppm) : 2.14 (2H, br t, J=8.1 Hz, CH2CH2CO), 2.87 (2H, br t, J=8.1 HJz, CU2CH2CO), 6.86 (2H, d, J=8.6 Hz, aromatic), 7.2 (2H, d, J=8.6 Hz, aromatic). Anal. Calcd. for C24H37F3O4S . 0.6 H2O: C 58.90, H 7.87, S 6.55. Found: C 58.86, H 7.79, S 6.63. Example 138 4-r4-r2-r2-rBis(4-chlorophenyl)methoxy1ethylsulfonynethoxy1phenyll-l,l.l- trifluoro-2-butanone 2-[Bis(4-chlorophenyl)methoxy]ethyl bromide. A mixture of 4,4'-dichlorobenzhydrol (4.40 g, 0.17 mmol) and 2- bromoethanol (3.0 g, 24.0 mmol) in benzene (50 ml) was treated with sulfuric acid (0.25 ml) and the resulting mixture was heated under reflux ι ^ for 1 h. The cooled mixture was diluted with ethyl acetate (200 ml), washed with saturated sodium bicarbonate, brine and dried over magnesium sulfate. Evaporation of the solvent gave an oil which was chromatographed on silica gel using a mixture of toluene and hexane (1:1) as eluent to give the title compound as a clear oil (5.13 g, 82%). 2-[2-[Bis(4-chlorophenyDmethoxy]ethylthio]ethanol A solution of 2-[bis(4-chlorophenyl)methoxy]ethyl bromide (5.13 g, 14.2 mmol) in N,N-dimethylformamide (50 ml) was treated at 22°C with powdered anhydrous potassium carbonate (3.0 g, 21.7 mmol) followed by 2-mercaptoethanol (1.25 g, 16.0 mmol). The resulting mixture was stirred at 22° for 18 h. The reaction mixture was then diluted with toluene (400 ml) washed with water, brine and dried over magnesium sulfate. Evaporation of the solvent gave an oil which was chromatographed on silica gel (elution ethyl acetate 0-10% in toluene) to give 4.93 g (96%) of the title material as a clear oil. Anal. Calcd. for C17H18CI2O2S: C 57.15, H 5.08, S 8.97. Found: C56.99, H 4.82, S 9.05. \ -. 3-[4-[2-[2-[Bis(4-chlorophenyDmethoxy]ethylthio]ethoxy]phenyl]propionic acid methyl ester A solution of methyl 3-(4-hydroxyphenyl) propionate (1.40 g, 7.77 mmol), 2-[2-[bis(4-chlorophenyl)methoxy]ethylthio]ethanol (2.80 g, 7.80 mmol) and triphenylphosphine (2.0 g, 7.8 mmol) in dry benzene (30 ml) was treated at 22°C with diethyl azodicarboxylate (1.34 g, 7.8) added dropwise over 5 min. After 18 h at 22°C, the reaction mixture was diluted with ethyl acetate (200 ml) washed with saturated sodium bicarbonate and dried over magnesium sulfate. Evaporation of the solvent gave an oil which was triturated in a mixture of hexane and toluene (6:4) to crystallize the triphenylphosphine oxide and the hydrazine side products. The filtrate was chromatographed on silica gel (elution ethyl acetate 0-5% in toluene) to give 2.90 g (71%) of the title material as an oil. Anal. Calcd. for C27H28CI2O4S: C 62.43, H 5.43, S 6.17. Found: C 61.89, H 5.21, S 6.11. 3-[4-[2-[2-[Bis(4-chlorophenyDmethoxy]ethylthio]ethoxy]phenyl]propionic acid A mixture of 3-[4-[2-[2-[Bis(4- chlorophenyl]methoxy]ethylthio]ethoxy]phenyl] propionic acid methyl ester (2.76 g, 5.31 mmol) and 80% aqueous ethanol (50 ml) was treated with a solution of potassium hydroxide (0.7 g, 10.6 mmol) in water (3 ml) and the resulting mixture was heated at 60°C for 1 h. The solvent was then concentrated in vacuo and the residue was diluted with water (30 ml) and dichloromethane (50 ml) and acidified to pH4 with 2N hydrochloric acid. The aqueous phase was extracted a second time with dichloromethane and the combined organic extracts were washed with brine and dried (magnesium sulfate). Evaporation of the solvent under reduced pressure gave 2.63 g (98%) of the title acid as a white solid. Anal. Calcd. for C26H26 I2O4S: C 61.78, H 5.18, S 6.34. Found: C 61.42, H 5.11, S 6.34. 4-[4-[2-[2-[Bis('4-chloropheny methoxy]ethylthio]ethoxy]phenyl]-l.l,l- trifluoro-2-butanone A solution of 3-[4-[2-[2-[bis(4- chlorophenyl)methoxy]ethylthio]ethoxy]phenyl]propionic acid (2.49 g, 4.93 mmol) in dry dichloromethane (25 ml) was treated at 22°C with oxalyl chloride (1.5 g, 11.8 mmol) and a small drop of N,N-dimethylformamide. After 1 h, the solvent and excess reagent were evaporated in vacuo and the residue was diluted with dry toluene (75 ml). The solution was then cooled to 0-5°C, treated with trifluoroacetic anhydride (3.12 g, 14.9 mmol) followed by pyridine (0.98 g, 12.4 mmol) added dropwise over 10 min. The reaction mixture was then allowed to warm up to 20°C and stirred for another 2 h. Then water (5 ml) was added dropwise and the mixture was stirred for another 15 min. The reaction mixture was then diluted with ethyl acetate (300 ml) washed with water, saturated sodium bicarbonate, brine and dried (magnesium sulfate). Evaporation gave an oil which was chromatographed on silica gel. Elution with a gradient of ethyl acetate (0- 4%) in toluene gave 2.35 g (85%) of the title material as an oil. Anal. Calcd. for C27H25CI2F3O3S.O.4 H2O: C 57.43, H 4.63, S 5.68. Found: C 57.42, H 4.41, S 5.49. 4-[4-[2-[2-[Bis(4-chloropheny methoxy]ethylsulfinyl]ethoxy]phenyl]-l.l.l- trifluoro-2-butanone A solution of 4-[4-[2-[2-[bis(4- chloropheny 1) methoxy ] ethyl thio ] ethoxy ] phenyl] - 1 , 1 , 1 -trifluoro-2- butanone (0.88 g, 1.58 mmol) in methanol (40 ml) was treated at 22°C with a solution of sodium periodate (0.34 g, 1.58 mmol) in water (2 ml). After 6.5 h the solid formed was filtered and the filtrate was evaporated in vacuo. The residue was diluted with ethyl acetate, washed successively with sodium bicarbonate, water and brine, dried (magnesium sulfate) and concentrated. The residue was chromatographed on silica gel (elution ethyl acetate) to give 0.691 g (76%) of the title material as an oil. Anal. Calcd. for C27H25 I2F3O4S. 0.6 H2O: C 55.51, H 4.52, S 5.49. Found: C 55.37, H 4.31, S 5.39. 4-[4-[2-[2-[Bis(4-chloropheny methoxy]ethylsulfonyl]ethoxy]phenyl]-l.l.l- trifluoro-2-butanone A solution of 4-[4-[2-[2-[bis(4- chlorophenyl)methoxy]ethylthio]ethoxy]phenyl]-l,l,l-trifluoro-2- butanone (1.51 g, 2.71 mmol) in dichloromethane (50 ml) was treated at 22°C with m-chloroperbenzoic acid (0.94 g, 5.4 mmol) and the resulting mixture was stirred for 2 h. The reaction mixture was then diluted with ethyl acetate, washed with sodium bicarbonate, brine and dried (magnesium sulfate). Evaporation and chromatography on silica gel (elution toluene-ethyl acetate 8:2) gave 1.46 g (92%) of the title material as an oil which crystallized upon standing: mp 98-100°C. IR (NaCl, film) u max (cm "1 ) 1755. α H NMR 400 MHz (CDCI3) d (ppm): 2.97 (2H, m), 3.02 (2H, m), 3.45 (2H, t, J=5.6 Hz), 3.53 (2H, t, J=5.6 Hz), 3.92 (2H, t J=5.6 Hz), 4.41 (2H, m), 5.39 (IH, s), 6.92 and 7.1-7.3 (12H, aromatic). Hydrated form: 2.15 and 2.87 (2m). Anal. Calcd. for C27H25CI2F3O5S: C 55.02, H 4.27, S 5.44. Found: C 54.83, H 4.36, S 5.54. The following compounds may be prepared by the general procedure of Scheme 9. no SCHEME 9 OI Scheme 9 (continued) ni. <>3 , Scheme 9B. \ ^ Example 159 4-f4-r2-r2-Hydroxyethylthio1ethoxylphenyn-l,l,l-trifluoro butanone. 3-[4-[2-(2-hydroxyethylthio)ethoxy]phenyl]propanoic acid, methyl ester A solution of methyl 3-[4-hydroxyphenyl) propionate (30.0 g, 0.166 mol), 2,2'-thiodiethanol (61.0 g, 0.50 mol) and triphenylphosphine (48.0 g, 0.183 mol) in dry benzene (450 ml) was treated at 22°C with diethyl azodicarboxylate (33.2 g, 0.19 mol) added dropwise over 10 min and the resulting mixutre was stirred at 22°C for 5 h. The reaction mixture was then diluted with ether (300 ml) washed with water, saturated sodium bicarbonate and brine. After drying (magnesium sulfate) the solvent was evaporated in vacuo and the residue was chromatographed on silica gel (elution toluene-ethyl acetate 85:15) to give 37.64 g (79%) of the starting material as a white solid: mp 47-48°C. Anal. Calcd. for C14H20O4S: C 59.13, H 7.09. Found: C 58.94, H 7.04. 3-r4-r2-(2-hydroxyethylthiolethoxy]phenyn propanoic acid. A solution of 3-[4-[2-(2-hydroxyethylthio)ethoxy]phenyl] propanoic acid, methyl ester (37.64 g, 0.132 mol) in 80% aqueous ethanol (300 ml) was treated with a solution of potassium hydroxide (17.0 g, 0.257 mol) in water (25 ml) and the resulting mixture was stirred at 22°C for 1 h. The solvent was then concentrated in vacuo and the residue was diluted with water (200 ml) and dichloromethane (200 ml). The aqueous phase was then adjusted to pH 2 with 6N hydrochloric acid and extracted several times with dichloromethane. The combined organic extracts were washed with brine, dried (magnesium sulfate) and evaporated to give 35.67 g (100%) of the title material as a white solid: mp 64-65°C. Anal. Calcd. for C 1 3H18O4S: C 57.76, H 6.71. Found: C 57.74, H 6.80. 1 7 " ? 3-f4-r2-(2-acetoxyethylthiolethoxylphenyll propanoic acid. A solution of 3-[4-[2-(2-hydroxyethylthio)ethoxy]phenyl] propanoic acid, (35.67 g, 0.13 mol) in a mixture of toluene (500 ml) and acetic acid (500 ml) was treated with p-toluenesulfonic acid (1.2 g) and then heated under reflux using a Dean-Stark apparatus for 2 h. The cooled mixture was concentrated in vacuo and the residue was diluted with ethyl acetate, washed with water and dried (magnesium sulfate). Evaporation of the solvent under vacuum gave a solid which was crystallized from hexane to give 36.13 g (88%) of title material as a white solid: mp 48-49°C. 4-r4-r2-(2-acetoxyethylthiolethoxylphenyll-l,l,l-trifluoro-2-butanone. A solution of 3-[4-[2-(2-acetoxyethylthio)ethoxy]phenyl] propanoic acid, (36.13 g, 0.115 mol) in dichloromethane (250 ml) was treated with oxalyl chloride (24 ml) and a drop of N,N-dimethylformamide. After 1 h at 25°C, the solvent and excess reagent were evaporated in vacuo. The residual oil was dissolved in toluene (250 ml) cooled to 0°C and treated with trifluoroacetic anhydride (49.0 ml, 0.347 mol). Then pyridine (19.0 ml, 0.232 mol) was added dropwise over 30 min and the resulting mixture was stirred at 22°C for 3 h. The solution was then cooled again to 0°C, treated dropwise with water (70 ml) and then stirred at 22°C for 30 min. The solution was then diluted with ethyl acetate, washed with water, saturated sodium bicarbonate, brine and dried (magnesium sulfate). Evaporation of the solvent in vacuo gave an oil which was chromatographed on silica gel. Elution with a mixture of dichlorimethane and ethyl acetate (0 - 2%) gave 26.10 g (62%) of the title material as an oil. \ T\ 4-r4-f2-(2-hydroxyethylthio1ethoxy1phenyl1-l,l,l-trifluoro-2-butanone. A solution of 4-[4-[2-(2-acetoxyethylthio)ethoxy]phenyl]-l,l,l-trifluoro-2- butanone (26.10 g, 71.6 mmol) in ethanol (275 ml) was treated at 22°C with a solution of potassium hydroxide (6.0 g, 91.0 mmol) in water (70 ml) and the resulting mixture was stirred for 30 min. The solvent was then evaporated in vacuo and the residual oil was dissolved in ethyl acetate, washed with water, brine and dried (magnesium sulfate). Evaporation of the solvent gave 23.0 g (100%) of the title material as an oil. Anal. Calcd. for C14H17F3O3S. 0.3 H2θ: C 51.31, H 5.41. Found: C 51.11, H 5.42. Example 160 4-f4-r2-f2-rBis(4-methylphenyl)methoxylethylthio1ethoxy1phenyn-l,l.l- trifluoro-2-butanone. A solution of 4-[4-[2-(2-hydroxyethylthio)ethoxy]phenyl]-l,l,l-trifluoro-2- butanone (1.20 g, 3.72 mmol), 4,4'-dimethylbenzhydrol (0.95 g, 4.47 mmol) and p-toluenesulfonic acid (0.035 g) in toluene (20 ml) was heated under reflux for 15 min. The cooled reaction mixture was diluted with ethyl acetate, washed with saturated sodium bicarbonate, brine and dried (magnesium sulfate). Evaporation of the solvent in vacuo and chromatography of the residue on silica gel (elution with a gradient of ethyl acetate 20-40% in hexane) gave 1.81 g (94%) of the title material as an oil. Anal. Calcd. for C29H31F3O3S: C 67.42, H 6.05. Found: C 67.43, H 6.08. The following compounds may be prepared by the general procedure of Scheme 9B. Table 9B λl »*3 l*M 1Y v λ%$ Λ^\ φc Λ<¥i ■^1- r Example 244 58 53 mCPBA 60 SI 4-f4-f2-f4-Bis(4-methylphenyl)butylsulfonyllethoxylphenyl-l,l,l-trifluoro- 2-butanone. l-Chloro^^-di-M-chlorophenyPbutane A solution of 4,4'-dichlorodiphenylmethane (4.37 g, 18.4 mmol) (Blackwell, J. et all, J. Chem. Soc, 1961, 1405) in dry tetrahydrofuran (50 ml) was treated at 0°C with butyllithium (12.1 ml of 1.6 M, 19.36 mmol) added dropwise over 15 min. After 15 min, the red solution was then added dropwise to a cold (-78°C) solution of l-chloro-3-iodopropane (15.0 g, 73.4 mmol) in dry tetrahydrofuran (120 ml). After 20 min at -78°C, the reaction mixture was quenched by the addition of saturated ammonium chloride (100 ml) and diluted with toluene. The organic phase was washed with brine and dried. The oil obtained after evaporation of the solvent was purified on silica gel (elution hexane- toluene 85:15) and distilled under vacuum to give 2.54 g (44%) of the title material as a clear oil: bp 110-130°C/1.5 torr (air bath temperature). ><k l-Iodo-4,4-di-ι / 4-chloropheny butane A solution of methyl l-chloro-4,4-di-(4-chlorophenyl)butane (1.77 g, 5.64 mmol) in 2-butanone (20 ml) was treated with sodium iodide (1.5 g) and heated under reflux for 18 h. The solid formed was filtered, the filtrate was evaporated and purified on silica gel (elution hexane-toluene 96:5) to give 2.13 g (93%) of the title material as a clear oil. n 2- [4-Bis-C4-chloropheny butylthio] ethanol A solution of l-iodo-4,4-di-(4-chlorophenyl)butane (3.22 g, 7.96 mmol) in N,N-dimethyl formamide (45 ml) was treated at 22°C with powdered anhydrous potassium carbonate (2.2 g) followed by 2-mercaptoethanol (0.71 g, 9.20 mmol) and the resulting mixture was stirred at 22°C for 18 h. The reaction mixture was then diluted with toluene (400 ml) washed with water and brine and dried over anhydrous magnesium sulfate. After evaporation of the solvent, the residue was chromatographed on silica gel (elution toluene-ethyl acetate 8:2) to give 2.58 g (92%) of the title material as a clear oil. Anal. Calcd. for Ci8H 2 oCl 2 OS: C 60.84, H 5.67, S 9.02. Found: C 61.12, H 5.75, S 9.28. S-^-t∑-^-Bis-^-chloropheny butylthiojethoxyjphenyljpropionic acid, methyl ester A solution of methyl 3-(4-hydroxyphenyl)propionate (1.22 g, 6.77 mmol), 2-[4-bis-(4-chlorophenyl)butylthio]ethanol (2.58 g, 7.26 mmol) and triphenylphosphine (1.95 g, 7.43 mmol) in dry benzene (30 ml) was treated at 22°C with diethyl azodicarboxylate (1.29 g, 7.41 mmol) added drowise over 10 min. After 3 h at 22°C, the solvent was evaporated and the residue was chromatographed on silica gel (elution hexane ethyl acetate, 84:16) to give 3.17 g (91%) of the title material as a clear oil. Anal. Calcd. for C28H30CI 2 O3S: C 64.99, H 5.84, S 6.20. Found: C 65.01, H 5.86, S 6.38. 3-[4-[2-[4-Bis-(4-chloropheny butylthio]ethoxy]phenyl]propionic acid. A suspension of 3-[4-[2-[4-bis-(4- chlorophenyl)butylthio]ethoxy]phenyl]propionic acid, methyl ester (3.09 g, 5.98 mmol) in ethanol (25 ml) was treated with a solution of potassium hydroxide (0.8 g, 14.3 mmol) in water (9.5 ml) and the resulting mixture was maintained at 35°C for 2 h. The pH of the solution was then adjusted to 4.0 with IN hydrochloric acid and the mixture was extracted with dichloromethane. The organic extract was dried (magnesium sulfate) and evaporated to give a white solid. Recrystallization from cyclohexane gave 2.93 g (97%) of the title material as a white solid: mp 89-92°C. 4-[4-[2-[4-Bis-(4-chloropheny butylthio]ethoxy]phenyl]-l.l,l-trifluoro-2- butanone. A solution of 3-[4-[2-[4-bis-(4- chlorophenyl)butylthio]ethoxy]phenyl]propionic acid (2.85 g, 5.66 mmol) in dichloromethane (25 ml) was treated with oxalyl chloride (1.65 g, 13.0 mmol) and a small drop of N,N-dimethylformamide. After 1 h at 22°C, the solvent and excess reagent were evaporated in vacuo and the residual acid chloride was dissolved in dry toluene (85 ml). The solution was then cooled to 0°C and treated with trifluoroacetic anhydride (3.57 g, 17.0 mmol) in dry toluene (15 ml) added dropwise over 10 min. After 3.5 h at 22°C, the mixture was cooled again to 0°C and treated dropwise with water (5 ml) and stirred for 15 min. The reaction mixture was then diluted with toluene (200 ml), washed with saturated sodium bicarbonate, brine and dried (magnesium sulfate). Evaporation of the solvent gave an oil which was chromatographed on silica gel. Elution with a mixture of hexane and ethyl acetate (75:25) gave 2.62 g (83%) of the title material as an oil. Anal. Calcd. for C28H27CI2F3O2S: C 60.54, H 4.90, S 5.77. Found: C 60.43, H 4.85, S 5.88. o ϋ 4-[4-[2-[4-Bis-(4-chlorophenyl)butylsulfinyl]ethoxy]phenyl]-l,l,l-trifluoro- 2-butanone. A solution of 4-[4-[2-[4-bis-(4-chlorophenyl)butylthio]ethoxy]phenyl]-l,l,l- trifluoro-2-butanone (0.741 g, 1.33 mmol) in methanol (35 ml) was treated with a solution of sodium periodate (0.32 g, 1.5 mmol) in water (1.5 ml) and the resulting mixture was stirred at 22°C for 18 h. The solid formed was filtered and the filtrate was evaporated in vacuo. The residue was diluted with ethyl acetate, washed with saturated sodium bicarbonate, brine and dried (magnesium sulfate). Evaporation of the solvent in vacuo gave an oil which was chromatographed on silica gel. Elution with a gradient of ethyl acetate in dichloromethane (40 - 90%) gave 0.654 g (86%) of the title material as a white solid: mp 31-35°C. Anal. Calcd. for C28H27CI2F3O3S. 0.4 H 2 0: C 58.12, H 4.84, S 5.54. Found: C 58.05, H 4.97, S 5.73. 2e! 4-[4-[2-[4-Bis-ι4-chloropheny butylsulfonyl]ethoxy]phenyl]-l,l,l-trifluoro- 2-butanone. A solution of 4-[4-[2-[4-bis-(4-chlorophenyl)butylthio]ethoxy]phenyl]-l,l,l- trifluoro-2-butanone (0.583 g, 1.05 mmol) in dichloromethane (25 ml) was treated at 22°C with m-chloroperbenzoic acid (0.592 g, 3.43 mmol) and the resulting mixture was stirred for 2 h. The reaction mixture was then diluted with ethyl acetate, washed with sodium bicarbonate, brine and dried (magnesium sulfate). Evaporation of the solvent in vacuo and chromatography of the residue on silica gel (elution ethyl acetate-hexane 1:1) gave 0.533 g (70%) of the title material as a clear oil. Anal. Calcd. for C28H2 7 CI2F3O 4 S. 0.4 H 2 0: C 56.55, H 4.71 S 5.39. Found: C 56.43, H 4.61, S 5.46. ID ^ The following compounds may be prepared by the general procedure shown above. Table 10 3 ZoM Table 11 Example 260 (Z)-4-[4-[2-(Dodecylsulfonyl)ethoxy]phenyl]-l,l,l-trifluoro-2-acetoxy-2- butene. A solution of 4-[4-[2-(dodecylsulfonyl)ethoxy]phenyl]-l,l,l-trifluoro-2- butanone (1.10 g, 2.30 mmol) in dichloromethane (15 ml) was cooled to - 25°C and treated with triethylamine (0.5 ml) and 4- dimethylaminopyridine (0.560 g, 4.58 mmol). Then acetic anhydride (0.65 ml, 6.9 mmol) was added and the resulting mixture was stirred at -25°C for 2.5 h. The solution was then diluted with ethyl acetate, washed with saturated sodium bicarbonate, dried (magnesium sulfate) and evaporated in vacuo. The residue was chromatographed on silica gel (elution toluene-ethyl acetate, 9:1) to give 0.94 g (78%) of a solid which was recrystallized from hexane to give white crystals: mp 48-49°C. Anal. Calcd. for C26H39F3O5S: C 59.98, H 7.55, S 6.16. Found: C 59.95, H 7.51, S 6.38. • zJbiβ Example 261 4-r4-f2-fBis(4-chlorophenyl)methoxy1ethylsulfonynethoxy1phenyn-l.l.l- trifluoro-2-butanol. A solution of 4-[4-[2-[bis(4- chlorophenyl)methoxy]ethylsulfonyl]ethoxy]phenyl]-l,l,l-trifluoro-2- butanone (0.77 g, 1.30 mmol) in tetrahydrofuran (45 ml) and water (5 ml) was treated with sodium borohydride (0.10 g, 2.6 mmol) and the resulting mixture was stirred at 22°C for 1 h. The reaction mixture was then diluted with ethyl acetate, washed successively with water and brine and then dried (magnesium sulfate). Evaporation of the solvent under reduced pressure gave an oil which was chromatographed on silica gel. Elution with a mixture of toluene and ethyl acetate (8:2) gave the title material as a white solid: mp 75-76°C. Anal. Calcd. for C27H27CI2F3O5S: C 54.83, H 4.60, S 5.42. Found: C 54.84, H 4.39, S 5.07. -to ") Example 262 (Z)-4-r4-r2-rBis-(4-chlorophenyl)methoxy)ethylsulfonyl)ethoxy1phenyn- l.l.l-trifluoro-2-acetoxy-2-butene. Reaction of 4-[4-[2-[bis(4-chlorophenyl)methoxy] ethy lsulf ony 1] ethoxy] phenyl] - 1,1,1 -tr ifluoro-2-butanone with acetic anhydride as described in example 260 gave the title material as an oil (85%). Anal. Calcd. for C29H27CI2F3O6S. 0.5 H2O: C 54.38, H 4.41, S 5.01. Found: C 54.38, H 4.26, S 4.86. Example 263 (Z)-4-f4-r2-(Dodecylsulfonyl)ethoxylphenyll-l.l.l-trifluoro-2-propionyloxy- 2-butene. Reaction of 4-[4-[2-(dodecylsulfonyl)ethoxy]phenyl]-l,l,l-trifluoro-2- butanone (0.87 g, 1.82 mmol) with propionic anhydride using the procedure described above gave 0.866 g (89%) of the title material as a white solid: mp 60-63°C. Anal. Calcd. for C27H41F3O5S: C 60.65, H 7.73, S 6.00. Found: C 60.51, H 7.83, S 6.01. Example 264 4-r4-r2-(Dodecylsulfonyl)ethoxy1phenyll-l,l,l-trifluoro-2-butanone. glycolic acid-ketal ester. A solution of 4-[4-[2-(dodecylsulfonyl)ethoxy]phenyl]-l,l,l-trifluoro-2- butanone (0.80 g) in toluene (40 ml) was treated with glycolic acid (0.16 g) and p-toluene sulfonic acid (0.10 g) and the resulting mixture was heated under reflux for 6 h. Additional quantities of glycolic acid (5 x 0.16 g) and p-toluenesulfonic acid (5 x 0.06 g) were added periodically after every hour of heating. The cooled reaction mixture was diluted with ethyl acetate, washed with saturated sodium bicarbonate and brine and dried over magnesium sulfate. Evaporation of the solvent under reduced pressure and chromatography of the residue on silica gel (elution toluene-ethyl acetate 8:2) gave 0.187 g (21%) of the title material as a white solid: mp 69- 71°C. Anal. Calcd. for C26H39F3O6S: C 58.19, H 7.33, S 5.97. Found: C 58.11, H 7.35, S 6.09. Example 265 4-[4-f2-(Dodecylsulfonyl)ethoxylphenyn-l,l,l-trifluorobutanone, thiazolidine derivative with 2-aminoethanethiol. A solution of 4-[4-[2-(dodecylsulfonyl)ethoxy]phenyl]-l,l,l- trifluorobutanone (0.60 g, 1.25 mmol) in dry toluene (50 ml) was heated under reflux and then treated with 2-aminoethanethiol (3 x 0.20 g) added in three portions over 12 h. The reaction mixture was then washed with brine and dried over magnesium sulfate. Evaporation of the solvent in 2.[ vacuo and chromatography of the residue on silica gel (elution toluene- ethyl acetate 85:15) gave 0.603 g (89%) of the title thiazolidine as a syrup. Anal. Calcd. for C26 I42F3NO3S2: C 58.07, H 7.87, N 2.60, S 11.93. Found: C 57.93, H 8.09, N 2.52, S 11.46. Example 266 (Z)-4-r4-r2-(Dodecylsulfony ethoxy1phenyn-l.l.l-trifluoro-2- diethylphosphoryloxy-2-butene. A solution of 4-[4-[2-(dodecylsulfonyl)ethoxy]ρhenyl]-l,l,l- trifluorobutanone (1.50 g, 3.13 mmol) in dry dichloromethane (40 ml) was cooled to 0°C and treated with triethylamine (0.87 ml) and 4- dimethylaminopyridine (0.77 g) then diethyl phosphorochloridate (1.35 ml) was added dropwise and the resulting mixture was stirred at 0°C for 2 h. The reaction mixture was then diluted with ethyl acetate, washed with sodium bicarbonate, brine and dried (magnesium sulfate). After evaporation of the solvent under reduced pressure, the residue was chromatographed on silica gel (elution toluene-ethyl acetate, 8:2) to give 1.539 (80%) of the title enol phosphate as white crystals (hexane) : mp 33°C. i l l Anal. Calcd. for C28H46F3O7PS: C 54.71, H 7.54, S 5.22. Found: C 54.82, H 7.64, S 5.39. Example 267 (Z)-4-r4-r2-(Dodecylsulfonyl)ethoxy1phenyn-l.l.l-trifluoro-2- ethylphosphoryloxy-2-butene sodium salt and (Z)-4-r4-r2-(Dodecylsulfonyl)ethoxylphenyll-l.l.l-trifluoro-2- phosphoryloxy-2-butene, disodium salt. A solution of (Z)-4-[4-[2-(dodecylsulfonyl)ethoxy]phenyl]-l,l,l-trifluoro-2- diethylphosphoryloxy-2-butene (0.778 g, 1.27 mmol) in acetonitrile (20 ml) was treated with chlorotrimethylsilane (1.0 ml) and potassium iodide (0.63 g) and the resulting mixture was heated under reflux for 5 h. The cooled mixture was then treated with sodium bicarbonate (1 g) and water (5 ml) and stirred for 30 min. The solid was then removed by filtration and the filtrate was concentrated in vacuo. The residue was then purified on silica gel using a mixture of ethyl acetate, methanol and water (7:3:0 to 65:35:5) as eluent. The first fractions gave the ethyl-phosphoryloxy sodium salt (0.210 g, 27%) as a white solid. Anal. Calcd. for C 2 6H 4 iF3θ 7 PSNa. 0.3 H 2 0: C 50.86, H 6.83, S 5.22. Found: C 50.81, H 6.98, S 5.32. The tail fractions gave the phosphoryloxy disodium salt (0.259 g, 34%) as a white solid. Anal. Calcd. for C24H36F 3 θ7PSNa 2 . 0.3 H 2 0: C 43.90, H 6.45, S 4.88. Found: C 43.97, H 6.08, S 5.08. The following prodrugs may be prepared by the general procedure described above. Table: Pro-drugs (1) 2-1?) Table: Pro-drugs (2)

Claims: CLAIMS We claim: 1. A compound of the formula wherein W is CH=CH, CH=N, O or S; R 1 is (Cι-C6)alkyl, (C2-C6)alkenyl, (C 2 -C 6 )alkynyl, (Ci-C6)alkoxy, o R 2 (Ci-C6)alkylthio, halo, hydroxy, cyano, — c — N— R 3 in which R 2 and R 3 are each independently hydrogen or (Ci-C6)alkyl, -COO-(C 1 -C 6 )alkyl, CF 3 , ( -C alkylphenyl, phenyl or phenyl substituted by one or more of o R 2 (C r C 6 )alkyl, -COO-(C 1 -C 6 )alkyl, — c — N- R 3 in which R 2 and R 3 are as defined above, halo, hydroxy, -0-(C 1 -C 6 )alkyl, -S^ -C alkyl or (C 2 -C 6 )alkenyl; p is 0, 1 or 2; A is V-(R C ) -; R c is a straight or branched chain alkyl group; n is 0 or an integer of from 1 to 6; Ά< R a and R b when taken together form an oxo group; or R a and R b are each independently hydrogen or OH; V is O, -S-, -SO-, -S0 2 , -CONH or NHCO when n is an integer of from 1 to 6 or V is (C 2 -C 6 ) alkenyl or a bond when n is 0 or an integer of from 1 to 6; D is -(CH2)m or a bond linking the ll , w ring to Y; m is an integer of from 1 to 6; I Y is -O-, -S-, -SO-, -Sθ2, -N-R 4 or a bond; R 4 is as defined below for R 7 ; Z is: in which B is: NR 10 — C - O— C— . — N-C— " N-C" , — SO, or a bond; R 9 R 9 X is S or O; q is an integer from 1 to 6; R 9 is hydrogen or (C 1 -C 6 )alkyl; R 10 is hydrogen, CN, NO2, OH, -0-(Cι-C6)alkyl, (Cι-C6)alkyl, phenyl or (Ci-C6)alkylphenyl; R and R 6 are each independently hydrogen or ( - g ) alkyl; R 7 and R 8 are each independently; (a) hydrogen; (b) (Ci-Ci8)alkyl; (c) (Ci-Ci8)alkyl substituted by one or more of (1) phenyl; (2) phenyl substituted by 1-5 fluoro, 1-3 halo (other than fluoro), l-3(Cι-C6)alkoxy, l-3(Ci-C6)alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Cι-C6)alkylthio, amino, 1-3 ( -C 6 ) alkylamino, di(Ci-C6)alkylamino, -CO2H, -COO- (Cι-C6)alkyl, -SO3H, -S02NHR 15 in which R 15 is hydrogen O R2 2 3 or (Ci-C6)alkyl, or — c— N— R 3 in which R and R are as defined above; (3) heterocyclic selected from oxadiazolyl, isoxazolyl, oxazolyl, furyl and thiazolyl; O (4) heterocyclic substituted by one or more of phenyl, phenyl substituted by 1-3 halo, (Cι-C6)alkoxy, (Cι-C6)alkyl, nitro, cyano, hydroxy, trifluoromethyl, ( - ) alkylthio, amino, ( - ) alkylamino, di(C x -C 6 ) alkylamino, C0 2 H, 5 -COO-(C r C 6 ) alkyl, -S0 3 H, S0 2 NHR 15 in which R 15 is 0 R 2 hydrogen or ( -C 6 ) alkyl, or - c- N-R 3 in which R 2 and R 3 are as defined above, ( -C 6 ) alkyl or ( - ) alkyl substituted by one or more phenyl or heterocyclic groups, said phenyl or heterocyclic group being unsubstituted or 10 substituted by 1-3 halo, 1-3 (C r C 6 ) alkoxy, 1-3 (C r C 6 ) alkyl, nitro, cyano, hydroxy, trifluoromethyl, ( -C alkylthio, amino, 1-3 ( -C 6 ) alkylamino, di -C alkylamino, COOH, -COO-(C C 6 ) alkyl, -S0 3 H, -S0 2 NHR 15 in which O R 2 R 15 is hydrogen or (C r C 6 ) alkyl, or - c- N- R 3 in which R 2 l-> and R 3 are each independently hydrogen or ( -C 6 ) alkyl, the heterocyclic radical being selected from imidazolyl, oxadiazolyl, isoxazolyl, pyrrolyl, pyrazolyl, oxazolyl, furyl, thianyl or thiazolyl; 0 (5) carboxy or -COO-(C r C 6 ) alkyl; (6) hydroxy, halo, -0-(C C 6 ) alkyl or -S-( -C 6 ) alkyl, with the proviso that the OH, ethers or thioethers cannot be on the carbon bearing the heteroatoms; 25 (7) cyano; -2.1? (8) halogen, trifluoromethyl or trifluoroacetyl; (9) CH2 L-R 16 in which L is R 17 R 17 0 O ■ N- — o- -SO- , -S0 2 - , —N-C—, —C-N—, — C— , .17 — O-C— , — C-O— , — N-C— —C-N—, R 17 R 7 or -0-SiR 16 R 1 8Rl9 or a ond m which R 16 and R 17 are each independently (Cι-Cιs)alkyl or (C2-Ci8)alkenyl or (Cι-Cιs)alkyl or (C2-Ci8)alkenyl substituted by one or more phenyl or heterocyclic radicals, said phenyl or heterocyclic radicals being unsubstituted or substituted by 1- 5 fluoro, 1-3 halo (other than fluoro), 1-3 (Cl-C6)alkoxy, l-3(Ci-C6)alkyl, nitro, cyano, hydroxy, 1-3 trifluoromethyl, 1-3 (Ci-C6)alkylthio, amino, l-3(Ci-C6)alkylamino, 1-3 di(Ci-C6)alkylamino, C0 2 H, 1-3 -COO(Ci- o R 2 C6)alkyl, —c-N- R 3 or -S0 2 NHR 9 in which R 9 is hydrogen or (Ci-C6)alkyl and R 2 and R 3 are as defined above; R 5 (b) (CH 2 ) q -C-R 6 N— B 1 - R 7 R 8 in which B 1 is x x x NR 10 — - . — c-o— , -C-N-R 9 ,— c-NR 9 , - so 2 -, -PO(OR 9 ) 2 or a bond; l|=ι providing that when B 1 is -PO(OR 9 ) 2 , then R 7 becomes R 9 , and when B 1 is X II _ ., „ 7 — c-o— or -S0 2 -, then R cannot be hydrogen; X, q, R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are as defined in (a); in which q, R 5 and R 6 are as defined above; 18 19 11 7 8 R , R and R are as defined below for R and R except that they may not be hydrogen, or R 18 and R 19 taken together with the nitrogen to which they are attached represent a 4, 5- or 6-membered heterocyclic ring and Y, R 7 and R 11 are as defined above, or R 18 , R 19 and R 11 taken together with the nitrogen to which they are attached represent pyridinium, said pyridinium group being unsubstituted or substituted by (Cι-Cχ2)alkyl, (Cι-Ci2)alkoxy, amino, (Cι-Ci2)alkylamino, di o , II ° R (Cι-Ci2)alkylamino, -c-o — (C r C 6 ) a lkyl, -S-(Cι-Ci2)alkyl, — C-N- R 3 in which R 2 and R 3 are as defined above, phenyl or phenyl (Cl-Clθ)alkyl; d) Z2C in which R 13 is (Cι-Ciδ)alkyl or (Cι-Cιs)alkyl substituted by carboxy, o O R 2 -c-o-(c r c 12 ) alkyl, - C- N-R 3 in which R 2 and R 3 are as defined above, hydroxy, -0-(C r C 6 ) alkyl or -S-(C r C 6 ) alkyl substituted by 1 or 2 phenyl or substituted phenyl groups, the substituents for the substituted phenyl groups being 1-5 fluoro or 1-3 halo (other than fluoro), ( - ) alkoxy, ( -C 6 ) alkyl, nitro, cyano, hydroxy, trifluoromethyl, ( -C alkylthio, amino, (C r C 6 ) alkylamino, di(C C 6 ) alkylamino, C0 2 H, COO-(C C 6 ) alkyl, O R 2 S0 3 H, S0 2 NHR 15 in which R 15 is hydrogen or (C C 6 ) alkyl or - C- N- R 3 in which R 2 and R 3 are as defined above; r is 0 or an integer of from 1 to 3; R 7 is as defined above; O o 0 R 2 M is -(CH2-) m T where T is - C— , - C- O , - C - N— , in which R 2 is as defined above, -S0 2 - or a bond when MR 7 is on nitrogen and providing O 11 that when T is — G — or -SO- or -S0 2 -, then R cannot be hydrogen, and T 0 I I ° 11 R K 14 is - — , — C-O— , -o-, -S-, -SO-, -SO2-, -N— or a bond when MR 7 is on a carbon atom of the heterocyclic ring; R is hydrogen or (Ci-C6)alkyl; m is 0 or an integer of 1-6; wherein Q is -O-, -S-, -SO- or -S0 2 -, and q, R 5 , R 6 and R 7 are as defined above, providing that when Q is -SO- or -S0 2 -, R 7 cannot be hydrogen; f) R 7 wherein R 7 is defined above, providing that when Y is -SO- or -S0 2 -, R 7 cannot be hydrogen; and R 18 and R 19 are phenyl or phenyl substituted by 1-3 halo, C_-C 6 ) alkoxy, (C α -C 6 ) alkyl, nitro, cyano, hydroxy, trifluoromethyl, ( - ) alkylthio, amino, (C C 6 ) alkylamino, di(C C 6 ) alkylamino, C0 2 H, -COO-(C C 6 ) alkyl, O R 2 -S0 3 H, S0 2 NHR 15 in which R 15 is hydrogen or ( -C 6 ) alkyl, or - C- N- R 3 in which R 2 and R 3 are as defined above; or a pharmaceutically acceptable salt, solvate or prodrug thereof. 2. A compound of claim 1 wherein W is CH=CH, D is a bond linking Y to the ring and Y is -O-. 3. A compound of claim 2 wherein R 1 is benzyl; p is 0, 1 or 2; A is V -(CH 2 ) n - wherein V is (C 2 -C 6 ) alkenyl or a bond; and n is 0 or an integer of from 1 to 6. 4. A compound of claim 3 wherein A is -(CH 2 ) n ; n is 0 or an integer of from 1 to 6; and the group -(CH 2 ) n -COCF 3 is in the meta or para position of the phenyl ring. 5. A compound of the formula wherein R 1 is benzyl; p is 0, 1 or 2; A is V-(CH 2 ) n -; V is (C 2 -C 6 ) alkenyl or a bond; n is 0 or an integer of from 1 to 6; R a and R b when taken together form an oxo group, or R a and R b are each independently hydrogen or OH; and Z is (a) in which B is ; X is S or O; q is an integer of from 1 to 6; R 9 is hydrogen or (C : -C 6 ) alkyl; R 10 is hydrogen, CN, N0 2 , OH, -0-(C C 6 ) alkyl, (C C 6 ) alkyl, phenyl or ( -C 8 ) alkylphenyl; 2.13 R 5 and R 6 are each independently hydrogen or ( - ) alkyl; and R 7 and R 8 are each independently a) hydrogen; b) (C C 18 ) alkyl; c) ( - g) alkyl substituted by one or more of (1) phenyl; (2) phenyl substituted by 1-5 fluoro, 1-3 halo (other than fluoro), 1-3 ( - ) alkoxy, 1-3 (C j -C 6 ) alkyl, nitro, cyano, hydroxy, trifluoromethyl, ( -C alkylthio, amino, 1-3 ( - ) alkylamino, di(C 1 -C 6 ) alkylamino, -C0 2 H, -COO-(C 1 -C 6 ) alkyl; -S0 3 H, - S0 2 NHR 15 O R 2 in which R 15 is hydrogen or (C C 6 ) alkyl, or - c- N- R 3 in which R 2 and R 3 are each independently hydrogen or (C j -C 6 ) alkyl; (3) heterocyclic selected from oxadiazolyl, isoxazolyl, oxazolyl, furyl and thiazolyl; (4) heterocyclic substituted by one or more of phenyl, phenyl substituted by 1-3 halo, (Ci-C6)alkoxy, (Ci-C6)alkyl, nitro, cyano, hydroxy, trifluoromethyl, (C C 6 ) alkylthio, amino, (C C 6 ) alkylamino, di( -C 6 ) alkylamino, C0 2 H, -COO-( -C 6 ) alkyl, -S0 3 H, O R 2 S0 2 NHR 15 in which R 15 is hydrogen or ( -C 6 ) alkyl, or - c- N- R 3 in which R 2 and R 3 are as defined above, ( -C alkyl or (C j -C 6 ) alkyl substituted by one or more phenyl or heterocyclic groups, said phenyl or heterocyclic group being unsubstituted or substituted by 1-3 halo, 1-3 ( - ) alkoxy, 1-3 ( -C 6 ) alkyl, nitro, cyano, hydroxy, trifluoromethyl, ( - ) alkylthio, amino, 1-3 ( - ) alkylamino, di(C r C 6 ) alkylamino, COOH, -COO-(C C 6 ) alkyl, -S0 3 H, -S0 2 NHR 15 o R 2 in which R 15 is hydrogen or (C α -C 6 ) alkyl, or - c- N- R 3 in which R 2 and R 3 are each independently hydrogen or (C C 6 ) alkyl, the heterocyclic radical being selected from imidazolyl, oxadiazolyl, isoxazolyl, pyrrolyl, pyrazolyl, oxazolyl, furyl, thianyl or thiazolyl; (5) carboxy or -COO^ - ) alkyl; (6) hydroxy, halo, -0-(C C 6 ) alkyl or -S(C α -C 6 ) alkyl, with the proviso that the OH, ethers or thioethers cannot be on the carbon bearing the heteroatoms; (7) cyano; (8) halogen, trifluoromethyl or trifluoroacetyl; or (9) CH2 L-R 16 in which L is R 17 R 17 Q O II — N- — O— -s— - so- - S0 2 - , — N- C— , — C- N— , — c— . 3 1 O O s s — O- C— , — C-O— — N- C— — C- N— , ' ' | ' I R 7 R 17 or -0-SiR 16 R!8Rl9 or a bond in which R 16 and R 17 are each independently (Cι-Ciδ)alkyl or (C2-Ci8)alkenyl or (Ci-Cis)alkyl or (C2-Cχ8)alkenyl substituted by one or more phenyl or heterocyclic radicals, said phenyl or heterocyclic radicals being unsubstituted or substituted by 1-5 fluoro, 1-3 halo (other than fluoro), 1-3 (Cι-C6)alkoxy, l-3(Cι-C6)alkyl, nitro, cyano, hydroxy, 1-3 trifluoromethyl, 1-3 (Ci-C6)alkylthio, amino, 1-3 (Ci-C6)alkylamino,l-3 di(Ci-C6)alkylamino, C0 2 H, 1-3 -COO o R 2 (Ci-C6)alkyl, -c-N- R 3 or -S0 2 NHR 9 in which R 9 is hydrogen or (Ci-C6)alkyl and R 2 and R 3 are as defined above; and R 18 and R 19 are phenyl or phenyl substituted by 1-3 halo, ( -C 6 ) alkoxy, ZXff " (C j -C 6 ) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (C : -C 6 ) alkylthio, amino, ( -Cg) alkylamino, di(C -Cg) alkylamino, C0 2 H, -COO-(C 1 -C 6 ) alkyl, -S0 3 H, S0 2 NHR 15 in which R 15 is hydrogen or o R 2 (Cj-Cg) alkyl, or - c- N- R 3 in which R 2 and R 3 are as defined above; ( ) in which B 1 is — 2 or a bond; providing that when B 1 is -PO(OR 9 ) 2 , then R 7 becomes R 9 , and when B 1 is X — c-o— or -S0 2 -, then R 7 cannot be hydrogen; and X, q, R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are as defined above in (a); 3 13 (c) (CH 2 ) - 7 13 in which R is (Ci-Cis)alkyl or (Ci-Cis)alkyl substituted by carboxy, o O R 2 -C-o-(c C 12 ) alkyl, - C- N- R 3 in which R 2 and R 3 are as defined above, hydroxy, - -(C_-<Z_) alkyl or -S-(C 1 -C 6 ) alkyl substituted by 1 or 2 phenyl or 1.1 ic substituted phenyl groups, the substituents for the substituted phenyl groups being 1-5 fluoro or 1-3 halo (other than fluoro), ( - ) alkoxy, (C j -C 8 ) alkyl, nitro, cyano, hydroxy, trifluoromethyl, ( -Cg) alkylthio, amino, ( -Cg) alkylamino, di(C 1 -C 6 ) alkylamino, CO z H, COO-(C 1 -C 6 ) alkyl, o R 2 S0 3 H, S0 2 NHR 15 in which R 15 is hydrogen or (C C 6 ) alkyl or -c-N- R 3 in which R 2 and R 3 are as defined above; r is 0 or an integer of from 1 to 3; R 7 is as defined above; O I I o n o || R f 2 M is -(CH2-) m T where T is - C— , - C ~ O , — c- N— , m which R 2 is as defined above, -S0 2 - or a bond when MR 7 is on nitrogen and providing ft that when T is — G— or -SO- or -S0 2 -, then R cannot be hydrogen, and T O O R 14 is -C— , — C-O— -O-, -S-, -SO-, -SO2-, — N— or a bond when MR 7 is on a carbon atom of the heterocyclic ring; 14 R is hydrogen or (Ci-C6)alkyl; m is 0 or an integer of 1-6; (d) wherein Q is -O-, -S-, -SO-, or -S0 2 - and q, R 5 , R 6 and R 7 are as defined above, providing that when Q is -SO- or -S0 2 -, R 7 cannot be hydrogen; or (e) R 7 where R 7 is as defined above, providing that when Y is -SO- or -S0 2 -, R 7 cannot be hydrogen; or a pharmaceutically acceptable salt, solvate or prodrug thereof. 6. A compound of the formula (CH 2 ) n COCF 3 wherein n is 0 or an integer of from 1 to 6, the substituent -(CH 2 ) n COCF 3 is in the meta or para position of the phenyl ring and Z is x in which B is — Q — or a bond; X is S or O; q is an integer of from 1 to 6; R 5 and R 6 are each independently hydrogen or (C r C lg ) alkyl; and R 7 and R 8 are each independently (a) hydrogen; (b) (Ci-Ci8)alkyl; (c) (Ci-Ciδ)alkyl substituted by one or more of (1) phenyl; (2) phenyl substituted by 1-5 fluoro, 1-3 halo (other than fluoro), 1-3 ( -Cg) alkoxy, 1-3 (Q-Q) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-C 6 ) alkylthio, amino, 1-3 (Q-Cg) alkylamino, di(C 1 -C 6 ) alkylamino, -C0 2 H, -COO-(C 1 -C 6 ) alkyl; -S0 3 H, - S0 2 NHR 15 in which R 15 is hydrogen or (C C 6 ) alkyl, o R 2 or - C- N- R 3 in which R 2 and R 3 are each independently hydrogen or (Q-Q) alkyl; (3) heterocyclic selected from oxadiazolyl, isoxazolyl, oxazolyl, furyl and thiazolyl; (4) heterocyclic substituted by one or more of phenyl, phenyl substituted by 1-3 halo, (Ci-C6)alkoxy, (Ci-C6)alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Cg) alkylthio, amino, (Q-Cg) alkylamino, di(Q-Q) alkylamino, CO z H, -COO-(Q-Q) alkyl, -S0 3 H, S0 2 NHR 15 in which R 15 is 0 R 2 II hydrogen or (Q-Q) alkyl, or -c-N-R 3 in which R 2 and R : are as defined above, (Q-Q) alkyl or (Q-Q) alkyl substituted by one or more phenyl or heterocyclic groups, said phenyl or heterocyclic group being unsubstituted or substituted by 1-3 halo, 1-3 (Q-Q) alkoxy, 1-3 (Q-Q) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Cg) alkylthio, amino, 1-3 (Q-C 6 ) alkylamino, di(Q-Q) alkylamino, COOH, -COO-(C C 6 ) alkyl, -S0 3 H, -S0 2 NHR 15 in which o R 2 R 15 is hydrogen or (Q-Q) alkyl, or -c-N-R 3 in which R 2 and R 3 are each independently hydrogen or (Q-Q) alkyl, the heterocyclic radical being selected from imidazolyl, oxadiazolyl, isoxazolyl, pyrrolyl, pyrazolyl, oxazolyl, furyl, thianyl or thiazolyl; (5) carboxy or -COO-(Q-Q) alkyl; (6) hydroxy, halo, -O-(Q-Q) alkyl or -S-(Q-Q) alkyl, with the proviso that the OH, ethers or thioethers cannot be on the carbon bearing the heteroatoms; (7) cyano; (8) halogen, trifluoromethyl or trifluoroacetyl; (9) CH2 L-R 16 in which L is R 17 R 17 0 — N- — o— — s- SO- , -S0 2 - , —N-C— , — C-N— , — C— , >17 — O-C— , —C-O— , — N-C— —C-N— , i ' I ' l R 17 R 17 or -0-SiR 16 R!8Rl9 or a bond in which R 16 and R 17 are each independently (Ci-Cis)alkyl or (C2-Ci8)alkenyl or (Ci-Cis)alkyl or (C2-Cχ8)alkenyl substituted by one or more phenyl or heterocyclic radicals, said phenyl or heterocyclic radicals being unsubstituted or substituted by 1- 5 fluoro, 1-3 halo (other than fluoro), 1-3 (Cι-C6)alkoxy, l-3(Cι-C6)alkyl, nitro, cyano, hydroxy, 1-3 trifluoromethyl, 1-3 (Ci-C6)alkylthio, amino, l-3(Cι-C6)alkylamino, 1-3 di(Cι-C6)alkylamino, C0 2 H, 1-3 -COO O R 2 (Cι-C6)alkyl, —c-N- R 3 or -S0 2 NHR 9 in which R 9 is hydrogen or (Ci-C6)alkyl and R 2 and R 3 are as defined above; and R 18 and R 19 are phenyl or phenyl substituted b Y 1-3 halo, (Q-Q) alkoxy, (Q-Q) alkyl, ^^ cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, (Q-Q) alkylamino, di(Q-Q) alkylamino, C0 2 H, -COO-(Q-Q) alkyl, -S0 3 H, O R 2 S0 2 NHR 15 in which R 15 is hydrogen or (Q-Q) alkyl, or - c- N- R 3 in which R 2 and R 3 are as defined above; or a pharmaceutically acceptable salt, solvate or prodrug thereof. 7. A compound of the formula in which R 1 is benzyl; p is 0, 1 or 2; n is 0 or an integer of from 1 to 6; the substituent -(CH 2 ) n COCF 3 is in the meta or para position of the phenyl ring; and Z is V i in which B 1 is 0 x NR 1 II -c— , c- 0-, - c- N- R 9 , - C - NR 9 , — so 2 — or a bond; q is an integer of from 1 to 6; X is S or O; R 5 and R 6 are each independently hydrogen or (Cχ-Ci8) alkyl; R 9 is hydrogen or (C1-C6) alkyl; R 10 is hydrogen, CN, N0 2 , OH, -0-(Cι-C6) alkyl or (Ci-Cό) alkyl; and R 7 and R 8 are each independently (a) hydrogen; (b) (Cι-Ci8)alkyl; (c) (Ci-Ci8)alkyl substituted by one or more of (1) phenyl; (2) phenyl substituted by 1-5 fluoro, 1-3 halo (other than fluoro), 1-3 (Q-Q) alkoxy, 1-3 (Q-Q) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, 1-3 (Q-Q) Z - alkylamino, di(Q-Q) alkylamino, -CO z H, -COO-(C 1 -C 6 ) alkyl; -S0 3 H, - S0 2 NHR 15 in which R 15 is hydrogen or (Q-Q) alkyl, o R 2 or - c- N - R 3 in which R 2 and R 3 are each independently hydrogen or (Q-Q) alkyl; (3) heterocyclic selected from oxadiazolyl, isoxazolyl, oxazolyl, furyl and thiazolyl; (4) heterocyclic substituted by one or more of phenyl, phenyl substituted by 1-3 halo, (Cι-C6)alkoxy, (Cι-C6)alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, (Q-Q) alkylamino, di(Q-Q) alkylamino, C0 2 H, -COO-(Q-Q) alkyl, -S0 3 H, S0 2 NHR 15 in which R 15 is O R 2 hydrogen or (Q-Q) alkyl, or - C- N- R 3 in which R 2 and R 3 are as defined above, (Q-Q) alkyl or (Q-Q) alkyl substituted by one or more phenyl or heterocyclic groups, said phenyl or heterocyclic group being unsubstituted or substituted by 1-3 halo, 1-3 (Q-Q) alkoxy, 1-3 (Q-Q) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, 1-3 (Q-Q) alkylamino, di(Q-Q) alkylamino, COOH, -COO-(Q-Q) alkyl, -S0 3 H, -S0 2 NHR 15 in which o R 2 R 15 is hydrogen or (Q-Q) alkyl, or -c- N-R 3 in which R 2 and R 3 are each independently hydrogen or (Q-Q) alkyl, the heterocyclic radical being selected from imidazolyl, oxadiazolyl, isoxazolyl, pyrrolyl, pyrazolyl, oxazolyl, furyl, thianyl or thiazolyl; (5) carboxy or -COO-(Q-Q) alkyl; (6) hydroxy, halo, -O-(Q-Q) alkyl or -S-(Q-Q) alkyl, with the proviso that the OH, ethers or thioethers cannot be on the carbon bearing the heteroatoms; (7) cyano; (8) halogen, trifluoromethyl or trifluoroacetyl; (9) CH2 L-R 16 in which L is — , O II O II s II s II — O- C— , — C- O— , — N- C— ( — C- N— , R 17 R 17 or -0-SiR 16 R 18 R 19 or a bond in which R 16 and R 17 are each independently (Ci-Cιs)alkyl or (C2-Ci8)alkenyl or (Cι-Cιs)alkyl or (C2-C 18) alkenyl substituted by one or more phenyl or heterocyclic radicals, said phenyl or heterocyclic radicals being unsubstituted or substituted by 1- 5 fluoro, 1-3 halo (other than fluoro), 1-3 (Cι-C6)alkoxy, l-3(Ci-C6)alkyl, nitro, cyano, hydroxy, 1-3 trifluoromethyl, 1-3 (Ci-C6)alkylthio, amino, l-3(Ci-C6)alkylamino, 1-3 di(Ci-C6)alkylamino, C0 2 H, 1-3 -COO o R 2 (Ci-C6)alkyl, —c-N- R 3 or -S0 2 NHR 9 in which R 9 is hydrogen or (Ci-C6)alkyl and R 2 and R 3 are as defined above; and R 18 and R 19 are phenyl or phenyl substituted by 1-3 halo, (Q-Q) alkoxy, (Q-Q) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, (Q-Q) alkylamino, di(Q-Q) alkylamino, C0 2 H, -COO-(C 1 -C 6 ) alkyl, -S0 3 H, 0 R 2 S0 2 NHR 15 in which R 15 is hydrogen or (Q-Q) alkyl, or -C-N-R 3 in which R 2 and R 3 are as defined above; or a pharmaceutically acceptable salt, solvate or prodrug thereof. 8. A compound according to claim 7 wherein the substituent -(CH 2 ) n COCF 3 is in the para position of the phenyl ring, R 5 and R 6 are both hydrogen, q is 1, 2 or 3, n is 2 or 3, B 1 is x x x NR1 ° -C — , -C-O—, -C-N-R 9 , -C-NR 9 , or — S0 2 — and R 7 and R 8 are each independently hydrogen or (Ci-C s)alkyl. 9. A compound according to claim 8 wherein q is 1, n is 2 and B X X x is-C — , -C-O-, -c-N-R 9 , or — S0 2 — . 10. A compound of the formula wherein n is 0 or an integer of from 1 to 6; the substituent -(CH 2 ) n COCF 3 is in the meta or para position of the phenyl ring; and Z is in which R 13 is (Cι-Cιs)alkyl or (Cι-Cιs)alkyl substituted by carboxy, o O R 2 -c-o-(c c 12 ) alkyl, -C- N-R 3 in which R 2 and R 3 are each independently hydrogen or (Q-Q) alkyl, hydroxy, -O-(Q-Q) alkyl or -S-(Q-Q) alkyl substituted by 1 or 2 phenyl or substituted phenyl groups, the substituents for the substituted phenyl groups being 1-5 fluoro or 1-3 halo (other than fluoro), (Q-Q) alkoxy, (Q-Q) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, (Q-Q) alkylamino, di(Q-Q) alkylamino, C0 2 H, COO-(Q-Q) alkyl, S0 3 H, S0 2 NHR 15 in which R 15 is hydrogen or (Q-Q) o II R I 2 - alkyl or -c-N- R 3 in which R and R are as defined above; r is 0 or an integer of from 1 to 3; R 7 is as defined below; O II o II o K R I 2 M is -(CH2-) m T where T is - C— , - c- O , - C - N— , m which R 2 is as defined above, -S0 2 - or a bond when MR 7 is on nitrogen and providing that when T is — ft G — or -SO- or -S0 2 -, then R cannot be hydrogen, and T 9 I I ° I I R K 14 is — C— , -C-O— , -o-, -S-, -SO-, -Sθ2-, -N— or a bond when MR 7 is on a carbon atom of the heterocyclic ring; 14 R is hydrogen or (Ci-C6)alkyl; m is 0 or an integer of 1-6; and R 7 is (a) hydrogen; .36 (b) (Cι-Ci8)alkyl; (c) (Cι-Ci8)alkyl substituted by one or more of (1) phenyl; (2) phenyl substituted by 1-5 fluoro, 1-3 halo (other than fluoro), 1-3 (Q-Q) alkoxy, 1-3 (Q-Q) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, 1-3 (Q-Q) alkylamino, di(Q-Q) alkylamino, -CO z H, -COO-(Q-Q) alkyl; -S0 3 H, - S0 2 NHR 15 in which R 15 is hydrogen or (Q-Q) alkyl, O R 2 or - c- N- R 3 in which R 2 and R 3 are each independently hydrogen or (Q-Q) alkyl; 5 (3) heterocyclic selected from oxadiazolyl, isoxazolyl, oxazolyl, furyl and thiazolyl; (4) heterocyclic substituted by one or more of phenyl, phenyl 0 substituted by 1-3 halo, (Ci-C6)alkoxy, (Cl-C6)alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, (Q-Q) alkylamino, di(Q-Q) alkylamino, C0 2 H, -COO-(Q-Q) alkyl, -S0 3 H, S0 2 NHR 15 in which R 15 is O R 2 hydrogen or (Q-Q) alkyl, or - c- N-R 3 in which R 2 and R 3 ^ are as defined above, (Q-Q) alkyl or (Q-Q) alkyl substituted by one or more phenyl or heterocyclic groups, said phenyl or heterocyclic group being unsubstituted or LSI- substituted by 1-3 halo, 1-3 (Q-Q) alkoxy, 1-3 (Q-Q) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, 1-3 (Q-Q) alkylamino, di(Q-Q) alkylamino, COOH, -COO-(Q-Q) alkyl, -S0 3 H, -S0 2 NHR 15 in which o R 2 R 15 is hydrogen or (Q-Q) alkyl, or -c-N- R 3 in which R 2 and R 3 are each independently hydrogen or (Q-Q) alkyl, the heterocyclic radical being selected from imidazolyl, oxadiazolyl, isoxazolyl, pyrrolyl, pyrazolyl, oxazolyl, furyl, thianyl or thiazolyl; (5) carboxy or -COO-(Q-Q) alkyl; (6) hydroxy, halo, -O-(Q-Q) alkyl or -S-(Q-Q) alkyl, with the proviso that the OH, ethers or thioethers cannot be on the carbon bearing the heteroatoms; (7) cyano; (8) halogen, trifluoromethyl or trifluoroacetyl; (9) CH2 L-R 16 in which L is >17 FV'C ■ N — o- — S— -SO- , -S0 2 - , —N-C—, — C-N— , — C— , .17 s II s II • O-C— , —C-O— , —N-C— f —C-N— , R 17 R 17 or -0-SiR 16 R 18 R 19 or a bond in which R 16 and R 17 are each independently (Ci-Cιs)alkyl or (C2-Ci8)alkenyl or (Ci-Ciδ)alkyl or (C2-Ci8)alkenyl substituted by one or more phenyl or heterocyclic radicals, said phenyl or heterocyclic radicals being unsubstituted or substituted by 1-5 fluoro, 1-3 halo (other than fluoro), 1-3 (Cι-C6)alkoxy, l-3(Cι-C6)alkyl, nitro, cyano, hydroxy, 1-3 trifluoromethyl, 1-3 (C -C6)alkylthio, amino, 1-3 (Cι-C6)alkylamino,l-3 di(Ci-C6)alkylamino, C0 2 H, 1-3 -COO O R 2 (Cι-C6)alkyl, —c-N- R 3 or -S0 2 NHR 9 in which R 9 is hydrogen or (Cι-C6)alkyl and R 2 and R 3 are as defined above; and R 18 and R« are phenyl or phenyl substituted by 1-3 halo, (Q-Q) alkoxy, (Q-Q) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, (Q-Q) alkylamino, di(Q-Q) alkylamino, C0 2 H, -COO-(Q-Q) alkyl, -S0 3 H, S0 2 NHR 15 in which R 15 is hydrogen or O R 2 (Q-Q) alkyl, or - C- N- R 3 in which R 2 and R 3 are as defined above; or a pharmaceutically acceptable salt, solvate or prodrug thereof. 11. A compound of the formula in which n is 0 or an integer of from 1 to 6, the substituent -(CH 2 ) n COCF 3 is in the meta or para position of the phenyl ring; and Z is R 5 -(CH 2 ^C-R 6 Q-R 7 wherein q is an integer of from 1 to 6; R 5 and R 6 are each independently hydrogen or (Ci-Cis)alkyl; Q is -O-, -S-, -SO-, or -S0 2 - ; and R 7 is (a) hydrogen; ( ) (Ci-Ci8)alkyl; (c) (Cl-Ci8)alkyl substituted by one or more of (1) phenyl; (2) phenyl substituted by 1-5 fluoro, 1-3 halo (other than fluoro), 1-3 (Q-Q) alkoxy, 1-3 (Q-Q) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, 1-3 (Q-Q) alkylamino, di(Q-Q) alkylamino, -C0 2 H, -COO-(Q-Q) alkyl; -S0 3 H, - S0 2 NHR 15 in which R 15 is hydrogen or (Q-Q) alkyl, O R 2 or - c- N - R 3 in which R 2 and R 3 are each independently hydrogen or (Q-Q) alkyl; (3) heterocyclic selected from oxadiazolyl, isoxazolyl, oxazolyl, furyl and thiazolyl; i¥0 (4) heterocyclic substituted by one or more of phenyl, phenyl substituted by 1-3 halo, (Cι-C6)alkoxy, (Cι-C6)alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, (Q-Q) alkylamino, di(Q-Q) alkylamino, C0 2 H, -COO-(Q-Q) alkyl, -S0 3 H, S0 2 NHR 15 in which R 15 is O R 2 hydrogen or (Q-Q) alkyl, or - c- N- R 3 in which R 2 and R 3 are as defined above, (Q-Q) alkyl or (Q-Q) alkyl substituted by one or more phenyl or heterocyclic groups, said phenyl or heterocyclic group being unsubstituted or substituted by 1-3 halo, 1-3 (Q-Q) alkoxy, 1-3 (Q-Q) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, 1-3 (Q-Q) alkylamino, di(Q-Q) alkylamino, COOH, -COO-(Q-Q) alkyl, -S0 3 H, -S0 2 NHR 15 in which O R 2 R 15 is hydrogen or (Q-Q) alkyl, or - c- N- R 3 in which R 2 and R 3 are each independently hydrogen or (Q-Q) alkyl, the heterocyclic radical being selected from imidazolyl, oxadiazolyl, isoxazolyl, pyrrolyl, pyrazolyl, oxazolyl, furyl, thianyl or thiazolyl; (5) carboxy or -COO-(Q-Q) alkyl; (6) hydroxy, halo, -O-(Q-Q) alkyl or -S-(Q-Q) alkyl, with the proviso that the OH, ethers or thioethers cannot be on the carbon bearing the heteroatoms; (7) cyano; 2_H \ (8) halogen, trifluoromethyl or trifluoroacetyl; (9) CH2 L-R 16 in which L is ?17 i17, R 17 0 • N- — O— ( — S— - SO - , - S0 2 - , — N- C— , — C- , — C- - O- C— , — C- O— , — N- C— — C- N— ' ' I ' l R 17 R 17 or -0-SiR 16 R 18 R 19 or a bond in which R 16 and R 17 are each independently (Cι-Cis)alkyl or (C2-Ciδ)alkenyl or (Cι-Ciδ)alkyl or (C2-Ciδ)alkenyl substituted by one or more phenyl or heterocyclic radicals, said phenyl or heterocyclic radicals being unsubstituted or substituted by 1-5 fluoro, 1-3 halo (other than fluoro), 1-3 (Cl-C6)alkoxy, l-3(Ci-C6)alkyl, nitro, cyano, hydroxy, 1-3 trifluoromethyl, 1-3 (Ci-C6)alkylthio, amino, 1-3 (Cι-C6)alkylamino,l-3 di(Cι-C6)alkylamino, C0 2 H, 1-3 -COO o R 2 (Cι-C6)alkyl, —c-N- R 3 or -S0 2 NHR 9 in which R 9 is hydrogen or (Ci-C6)alkyl and R 2 and R 3 are as defined above; and R 18 and RW are phenyl or phenyl substituted by 1-3 halo, (Q-Q) alkoxy, (Q-Q) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, (Q-Q) alkylamino, di(Q-Q) alkylamino, CO z H, -COO-(Q-Q) alkyl, -S0 3 H, S0 2 NHR 15 in which R 15 is hydrogen or O R 2 (Q-Q) alkyl, or - c- N- R 3 in which R 2 and R 3 are as defined above; or a pharmaceutically acceptable salt, solvate or prodrug thereof. 12. A compound of the formula in which n is 0 or an integer of from 1 to 6; the substituent -(CH 2 ) n COCF 3 is in the meta or para position of the phenyl ring; and Z is (a) hydrogen; (b) (Ci-Ci 8 )alkyl; (c) (Ci-Ciδ)alkyl substituted by one or more of (1) phenyl; (2) phenyl substituted by 1-5 fluoro, 1-3 halo (other than fluoro), l-3(Ci-C6)alkoxy, l-3(Ci-C6)alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Cι-C6)alkylthio, amino, 1-3 (Q-Q) alkylamino, di(Cι-C6)alkylamino, -CO2H, -COO- (Ci-C6)alkyl, -SO3H, -S02NHR 15 in which R 15 is hydrogen, 0 ^ 2 2 3 (Ci-C6)alkyl, or — c— N— R 3 in which R and R are each independently hydrogen or (Q-Q) alkyl; (3) heterocyclic selected from oxadiazolyl, isoxazolyl, oxazolyl, furyl and thiazolyl; (4) heterocyclic substituted by one or more of phenyl, phenyl substituted by 1-3 halo, (Cι-C6)alkoxy, (Cι-C6)alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, (Q-Q) alkylamino, di(Q-Q) alkylamino, C0 2 H, -COO-(Q-Q) alkyl, -S0 3 H, S0 2 NHR 15 in which R 15 is O R 2 hydrogen, (Q-Q) alkyl, - c- N- R 3 in which R 2 and R 3 are as defined above, (Q-Q) alkyl or (Q-Q) alkyl substituted by one or more phenyl or heterocyclic groups, said phenyl or heterocyclic group being unsubstituted or substituted by 1-3 halo, 1-3 (Q-Q) alkoxy, 1-3 (Q-Q) alkyl, nitro, cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, 1-3 (Q-Q) alkylamino, di(Q-Q) alkylamino, COOH, -COO-(Q-Q) alkyl, -S0 3 H, -S0 2 NHR 15 in which O R 2 R 15 is hydrogen or (Q-Q) alkyl, or - c- N- R 3 in which R 2 and R 3 are each independently hydrogen or (Q-Q) alkyl, the heterocyclic radical being selected from imidazolyl, oxadiazolyl, isoxazolyl, pyrrolyl, pyrazolyl, oxazolyl, furyl, thianyl or thiazolyl; (5) carboxy or -COO-(Q-Q) alkyl; (6) hydroxy, halo, -O-(Q-Q) alkyl or -S-(Q-Q) alkyl, with the proviso that the OH, ethers or thioethers cannot be on the carbon bearing the heteroatoms; (7) cyano; (8) halogen, trifluoromethyl or trifluoroacetyl; (9) CH2 L-R 16 in which L is 317 R I 17 0 n ■ N- -O— — S- - so- , - so 2 - , — N- C— , — C- N— , — 5 17 — O- C— , — C- 0— , — N- C— — C- N— , ' ' | ' I R 17 R 7 or -0-SiR 16 R 18 Rl9 G r a bond in which R 16 and R 17 are each independently (Cι-Cιs)alkyl or (C2-C18) alkenyl or (Cι-Cιs)alkyl or (C2-C is) alkenyl substituted by one or more phenyl or heterocyclic radicals, said phenyl or heterocyclic radicals being unsubstituted or substituted by 1- 5 fluoro, 1-3 halo (other than fluoro), 1-3 (Cι-C6)alkoxy, l-3(Cι-C6)alkyl, nitro, cyano, hydroxy, 1-3 trifluoromethyl, 1-3 (Cι-C6)alkylthio, amino, 1- 3(Ci-C6)alkylamino, 1-3 di(Ci-C6)alkylamino, C0 2 H, 1-3 -COO o R 2 (Cι-C6)alkyl, —c-N- R 3 or -S0 2 NHR 9 in which R 9 is hydrogen or (Cι-C6)alkyl and R 2 and R 3 are as defined above; and R 18 and R 19 are phenyl or phenyl substituted by 1-3 halo, (Q-Q) alkoxy, (Q-Q) alkyl, n itro cyano, hydroxy, trifluoromethyl, (Q-Q) alkylthio, amino, (Q-Q) alkylamino, di(Q-Q) alkylamino, C0 2 H, -COO-(Q-Q) alkyl, -S0 3 H, o R 2 S0 2 NHR 15 in which R 15 is hydrogen or (Q-Q) alkyl, or - c- N- R 3 in which R 2 and R 3 are as defined above; or a pharmaceutically acceptable salt, solvate or prodrug thereof. 13. A compound selected from those of the following: 6 -I 1 * wherein (a) R 25 is -(CH 2 ) 3 CH L 3 ' (b) R 25 is -(CH 2 ) 3 C0 2 QH 5 ; (c) R^ is -(CH 2 ) 3 CONHC 2 H 5 ; (d) R 25 is -COCF 3 ; (e) R 25 is -COC 6 H 5 ; and (f) R is -PO(OC 2 H 5 ) 2 ; or a pharmaceutically acceptable salt thereof. 14. A compound selected from those of the following: wherein 2, <o (a) R 20 is -CO(CH 2 ) 10 CH 3 (b) R 20 is -COCH(p-chlorophenyl) 2 ; and (c) R 20 is -S0 2 (CH 2 ) n CH 3 ; or a pharmaceutically acceptable salt thereof. 15. A compound selected from those of the followiing: wherein (a) X" and X 1 " are CI; (b) X" and X 1 " are F; (c) X" and X" are OCH 3 ; or (d) X" is CI and X'"is OCH 3 ; or a pharmaceutically acceptable salt thereof. 16. A compound selected from those of the following: wherein (a) n is 0; (b) n = 1; and (c) n = 2; or a pharmaceutically acceptable salt thereof. 17. A compound selected from those of the following: wherein (a) n = 0; (b) n = 1; and (c) n = 2; or a pharmaceutically acceptable salt thereof. 18. A compound of the formula: or a pharmaceutically acceptable salt thereof. 19. A compound of the formula or a pharmaceutically acceptable salt thereof. 20. A compound of the formula /- 1Η or a pharmaceutically acceptable salt thereof. 21. A compound selected from those of the following: wherein (a) R 26 amd R 27 are both CH 3 or -(Q-Q)alkyl-CF 3 ; (b) R 26 and R 27 are both CI, F or Br; (c) X a and X b are both OCH 3 or SCH 3 ; (d) X a is CI and X b is OCH 3 ; and (e) X a and X b are both C0 2 -(Q-Q)alkyl; or a pharmaceutically acceptable salt thereof. z-st 22. A compound selected from those of the following: wherein (a) R 20 is -CO(CH 2 ) 10 CH 3 ; (b) R 20 is (c) R 20 is -S0 2 (CH 2 ) n CH 3 ; or a pharmaceutically acceptable salt thereof. 23. A compound selected from those of the following: 2.- " , wherein (a) n is 1 and R 21 is OCH. (b) n is 1 and R 21 is CI; (c) n is 2 and R 21 is OCH 3 ; and (d) n is 1-4 and R 21 is OCH 3 or CI; or a pharmaceutically acceptable salt thereof. 24. A compound selected from those of the following: wherein (a) R 22 is hydrogen and R 23 is CI; (b) R 22 is -C0 2 CH 3 and R 23 is -OCH 3 ; or a pharmaceutically acceptable salt thereof. 25. A compound selected from those of the following: wherein (a) R 24 is CI; and (b) R 4 is -OCH 3 ; or a pharmaceutically acceptable salt thereof. 26. The compound of the formula 2 " 3 27. The compound of the formula 28. The compound of the formula 29. The compound of the formula ^ 30. The compound of the formula 31. A compound of the formula 32. The compound of the formula 33. A pharmaceutical composition for the inhibition of cytosolic phospholipase A 2 comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier. 34. A method of inhibiting cytosolic phospholipase A 2 in a mammal in need thereof, comprising administering to said mammal a therapeutically effective amount of a compound of claim 1.

Inventors: BANVILLE JACQUES, BURKE JAMES R, GAI YONGHUA, JOHNSON GRAHAM, ZUSI FRED CHRISTOPHER, BANVILLE, JACQUES, BURKE, JAMES, R., GAI, YONGHUA, JOHNSON, GRAHAM, ZUSI, FRED, CHRISTOPHER
Applicants: SQUIBB BRISTOL MYERS CO, BRISTOL-MYERS SQUIBB COMPANY
Application year: 1998
Main classification: A61K
IPC codes: C07C17, C07C25, C07C45, C07C49, C07C69, C07C217, C07C229, C07C233, C07C235, C07C311, C07C317, C07C323, C07D207, C07D211, C07D215, C07D231, C07D271, C07D277, C07D311, C07D313, C07D317, C07F7, C07F9