NEW PIPERAZINYL-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKINE CARBOXAMIDES

Abstract: The invention relates to new piperazinyl-substituted pyridylalkane alkene and alkine acid amides with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group according to general formula (I) as well as methods for the production of these compounds, medicaments containing these and their production as well as their therapeutic use, especially as cytostatic agents and immunosuppressive agents, for example in the treatment or prevention of various types of tumors and control of immune reactions such as autoimmune diseases.

Description: New Piperazinyl-Substituted Pyridylalkane, Alkene and Alkine Carboxamides The invention relates to new piperazinyl-substituted pyridyl- alkane, alkene and alkine carboxamides with a saturated, one or several-fold unsaturated hydrocarbon residue in the carboxylic acid portion, methods for the synthesis of these compounds, medicaments containing these and their production as well as their therapeutic use especially as cytostatic agents and immunosuppresive agents, for example, in the treatment or prevention of various types of tumors and control of immune reactions, for example of autoimmune diseases . A pressing need exists for new pharmaceuticals and/or medicaments for cytostatic therapy which not only possess a strong activity, but also exert diminished side effects in comparison to many classical cancerostatic agents, whereby treatment of a broad as possible spectrum of tumors should be made accessible. Furthermore, effective cytostatic agents for an efficient therapy should be made available. Active ingredients of this type should also be exceptionally suitable in the mentioned indications for a combination therapy, be it in connection with other cytostatic agents or with radiation (for example X-rays, radioactive elements, such as cobalt, or linear accelerator, etc.), with operative procedures, heat treatment, etc. Additionally, from another point of view, there exists a strong need in the field of tumor therapy for new compounds, for example for overcoming or avoiding resistances, which enrich the pallet of cancerostatics based on new modes of action in the ideal case. This object was successfully solved by the creation of the piperazinyl-substituted pyridylalkane, alkene and alkine carboxamide derivatives as defined in detail in the claims and medicaments containing these as well as the use of these compounds, optionally in combination with other suitable active ingredients and adjuvants, for cytostatic and immunosuppressive therapy or prevention. It is known that various pyridine compounds or piperazine derivatives substituted in a specific manner have pharmacologically useful properties - however, in contrast to the actions of the compounds according to the invention, these lie in completely different fields of indication. Thus, ω-pyridyl alkane and/or alkene amides with antiallergic activity are described in EP 0 210 782 which are referred to as having a 5-lipoxygenase-inhibiting and anti- histamine action, wherein the amide components of these compounds contain a piperizine or homopiperizine ring and the pyridine ring can be linked together in the 2-, 3- or 4- position. However, corresponding overlapping compound groups are excluded from the present claimed scope of protection according to the invention. JP 63,179,869 describes further pyridyl amides, ω-pyridyl alkane and alkene amides as anti-allergic effective substances containing a substituted piperidine ring in the amine component. Similarly structured compounds with the same properties are mentioned in Chem. Pharm. Bull 37, 100-105 (1989) as well as in J. Med. Chem. 1989, 583-593. The synthesis and pharmacological evaluation of heterocyclic carboxamides which can be substituted at an end of the molecule by completely different heterocycles such as thiophene, guinoline, indole, benzimidazole or indazole as well as pyridine are described in J. Med. Chem., 1996, pages 4692-4706. As opposed to the compounds according to the invention, those published carboxamides possess an activity directed against psychoses . A few particularly named piperazine-substituted pyridyl carboxamides and/or their formula group therein are not encompassed by the present protective scope of the compounds of the invention according to the meanings given in the present claims because they have a direct bond instead of the structural element A. Based on the completely different therapeutic possibility of the known compounds in the field of psychiatry as compared to the indications according to the invention, it could not be expected that the compounds of the present invention would have the named cancerostatic and immunosuppressive effects . Pyridyl ureas, pyridyl thioureas and pyridyl carbonamides, wherein the amide portion is bound over an aryl- substituted alkyl chain with a piperidine ring or piperidine ring or piperazine ring, are described for example in EP-A-0 428 434 or in EP-A-0 512 902 as antagonists of the neurokinin receptor and substance P. Furthermore, pyridyl (alkyl) carbonamides, pyridyl (alkyl) εulfonamides and analogous ureas, wherein the amide portion is bound to piperidine ring over an alkyl chain, are disclosed in EP-A-0 479 601 as active ingredients with anti-arrhythmic properties . Further structurally closely related compounds are represented by the piperidine compounds described in EP-A-0 330 026. However, no 3-pyridyl derivatives were concretely described and no concrete examples were disclosed in this publication, aside from a single compound which is described below. These known compounds are distinguished by an anti- cholinesterase activity, an anti-amnesia activity as well as activities directed against hyperkinesia, senile dementia, mania and Alzheimer's disease. In WO 91/15 485, the production of pyridine-3 , 5-dicarboxylic acid esters and amides as well as their use for the treatment of tumor conditions is described. These compounds differ from the compounds according to the invention described below in very important structural features, for example by the dicarboxyl grouping on the pyridine ring or the absence of the hydrocarbon chain between the pyridine ring and the amide grouping. The compounds disclosed in WO 89/07 443 in the form of optically pure R (-) -niguldipin and further analogous dihydropyridines with cytotoxic activity have larger structural differences. However, as compared to these known compounds, the compounds according to the invention unexpectedly possess a better activity and a wider spectrum of action despite the large structural difference. In the international PCT patent applications WO 95/10516, WO 96/31477, WO 96/31478 or for example in WO 95/10515, tricyclic amide compounds are described which possess an anti-proliferative activity. All of these compounds described therein are distinguished in that they must imperatively possess a tricyclic anellated ring system with at least one nitrogen atom, for example 6, ll-dihydro-5H- benzo [5, 6] cyclohepta [1, 2-b] pyridinyl ring system as a pharmaphoric group, whereby the molecule portion opposite this tricyclic anellated system is uncommonly variable and represents one of many variation possibilities among numerous substitution possibilities of the given pyridyl substitution. A further meaningful difference in the substitution of these molecules in comparison to the compounds according to the invention is to be seen in the lack of the present structural element D, i.e. both heterocycles found in opposition are directly bound over the carboxy group without being bound over an alkaline chain found there. A further essential difference of the compounds according to the invention in comparison to these tricyclic compounds is to be recognized in the presence of the terminal 3-pyridyl- substitution which must be present. The presence of this heterocyclic ring required according to the invention as well as the particular bond in the 3-position according to the substitution of the invention in comparison to the above mentioned anti-proliferative compounds of the state of the art indicates that this 3-pyridyl group is an important factor for the anti-tumor action. In fact, the compounds according to the invention cover a different tumor spectrum from those named in the PCT/WO publications with this necessarily present tricyclic anellated ring system. In the mentioned PCT/WO publications of the state of the art, a treatment possibility in tumors is merely mentioned which is made in connection with a potential inhibition of the farnesyl protein transferase, whereby this mechanism relates to the expression of the activated ras- oncogene . In contrast to this, the compounds according to the invention with the 3 -pyridyl-substitution required according to the invention are not limited to the therapy of tumor cells of this type with abnormal production of the ras- oncogene; rather, the therapy possibilities with the new compounds according to the invention extend to the combat of numerous other types of tumors with different causal mechanisms as well as immunosuppressive treatment possibilities such as autoimmune diseases. In view of this art, the finding that the compounds according to the general formula (I) with the particular substitutions defined below have superior pharmacological activities which make them particularly suitable in an excellent manner for the therapy of abnormal cell growth such as tumor illnesses over a broad anti-proliferative spectrum, was completely unexpected. The pharmacological finding that, aside from the cytostatic effectiveness, especially with different tumor spectra, the compounds according to the invention also possess immunosuppressive properties and additionally favorable abortive properties without harmful mutagenic effects is to be considered as equally surprising. Structurally close pyridyl compounds wherein instead of the piperazine ring, a cyclic non-aromatic heterocyclic ring residue with merely one ring nitrogen atom and optionally an additional ring oxygen atom, preferably a piperidinyl residue, is incorporated as well as their use especially as cytostatic agents are subject matter of the older patent applications P 196 24 704.7-44, P 196 24 668.7-41 as well as P 196 24 659.8-44 which have not yet been published. The most important differentiating feature of the new compounds according to the invention with respect to these older, non-prepublished compounds is therefore the structural feature E which in the present application always represents especially piperazine or hexahydro-1, 4-diazepine . These new piperazinyl-substituted pyridyl carboxamides correspond to the following general formula: wherein the structural element E has the following meaning: ) whereby q is 1, 2 or 3 and therewith can represent the N- heterocyclic ring piperazine, hexahydro-1, 4- diazepine or octahydro-1, 4-azocine . The meaning of the remaining substituents and the preferred ' embodiments of the compound groups according to the invention falling under the general formula as well as particularly preferred end products are defined in claims 1 to 7 in detail . The compounds of Formula (I) , which represent the end products can optionally exist as cis- and trans -isomers, E- and Z-isomers, for example when A is a cyclopropane ring or D contains one or more double bonds. Subject matter of the invention is the pure isomers as well as their mixtures. Furthermore, the compounds of Formula (I) can contain one or more asymmetric carbon atoms and, as a result, exist in the form of different optical isomers (enantiomers , diastereomers) . The invention includes all optical isomers and their racemic or non-race ic mixtures. Finally, compounds of Formula (I) can exist as endo/exo- isomers in case the ring system E is bicyclic. The pure endo- and exo- isomers as well as their mixtures are also comprised by the invention. Compounds of Formula (I) , in which G is a heterocyclic aromatic ring or contains such in an anellated ring system can optionally be present as tautomers when this heterocyclic ring is substituted by free hydroxy-, mercapto- or amino groups. In this case, the invention includes all tautomeric forms . Subject matter of the invention are further pharmacologically acceptable acid addition salts of the compounds of Formula (I) with inorganic or organic acids. Preferable examples for addition salts with suitable inorganic acids are hydrochlorides, hydrobromides, hydroiodides, sulfates and phosphates. Addition salts of organic acids are preferably acetates, benzoates, citrates, fumarates, gluconates, malateε, maleates, methanesulfonates, lactates, oxalates, succinates, tartrates and tosylates . Compounds of Formula (I) as well as their acid addition salts can also be optionally present as hydrates or other solvates. The invention includes such hydrates and solvates . In the compounds of Formula (I) , the definitions for the atoms or atomic groups preferably have the following meanings : Halogen means fluorine, chlorine, bromine or iodine; Alkyl can be straight chained or branched and preferably signifies a C 1 -C 6 -alkyl residue, especially a methyl-, ethyl - , propyl-, isopropyl-, butyl-, isobutyl-, sec-butyl-, tert- b utyl-, cyclopropylmethyl- , pentyl-, isopentyl-, tert-pentyl- , neopentyl-, cyclopropylethyl- , cyclobutylmethyl- or hexyl group . Alkylene signifies for example methylene, ethylene, propylene, tetramethylene, pentamethylene, hexamethylene, heptamethylene, octamethylene, nonamethylene or decamethylene . Alkenyl preferably signifies C3-Cg-alkenyl and can be straight chained or branched and preferably signifies an allyl-, 2-butenyl-, 3-butenyl-, 2-methyl-2-propenyl- , 2- pentenyl-, 4-pentenyl-, 2-methyl-2-butenyl- , 3-methyl-2- butenyl-, 2-hexenyl-, 5-hexenyl-, 4-methyl-3-pentenyl- or 2 , 2-dimethyl-3-butenyl-group. Alkenylene signifies for example ethenylene, propenylene, butenylene, pentenylene, hexenylene, hexadienylene, heptenylene, octenylene, nonenylene or decenylene. Alkinyl preferably signifies C2-Cg-alkinyl which can be straight chained or branched and can preferably signify an ethinyl-, propargyl-, 2-butinyl-, 3-butinyl-, 4-pentinyl-, 5- hexinyl- or 4-methyl-2 -pentinyl group. Alkinylene signifies for example propinylene, butinylene, pentinylene, hexinylene, hexeninylene, heptinylene, octinylene, noninylene or decinylene. Cycloalkyl is preferably a C3-Cg-cycloalkyl residue, especially a cyclopropyl- , cyclobutyl-, cyclopentyl- , cyclohexyl-, cycloheptyl- or cyclooctyl group. Hydroxyalkyl contains a hydroxyl group in one of the above mentioned alkyl residues, especially in a C^-Cg-alkyl residue, whereby among the C_-Cg-hydroxyalkyl residues, the hydroxymethyl- and the hydroxyethyl residue are preferred. Aside from the oxygen atom, alkoxy, alkenyloxy, alkinyloxy contain one of the above mentioned preferred C^-Cg-alkyl- , C3-Cg-alkenyl- and/or C3-Cg-Alkinyl groups. Particularly preferred groups for this are the methoxy- , ethoxy- , isopropoxy-, tert-butoxy- , allyloxy- and propargyloxy groups, Alkoxy, especially C^-Cg-alkoxy, entirely or partially replaced by fluorine is for example difluoromethoxy, trifluoromethoxy or 2 , 2, 2-trifluoroethoxy . Aside from the sulphur atom, alkylthio, alkenylthio, alkinyl- thio contain one of the above mentioned preferred C^-Cg- alkyl-, C3-Cg-alkenyl- or C3-Cg-alkinyl groups. Preferred groups among these are the ethylthio-, ethylthio-, isopropylthio- and tert-butylthio groups. Cyclopentyloxy- and cyclopentylthio- and/or cyclohexyloxy- and cyclohexylthio residues represent preferred C3-C8 -cycloalkyloxy and C3-Cg-cycloalkylthio. Aside from the oxygen atom, alkanoyloxy groups preferably contain an aliphatic acyl group with 1 to 7 carbon atoms. Among preferred alkanoyloxy groups are the acetoxy- , propionyloxy- and pivaloyloxy groups . Alkoxycarbonyl groups, preferably C 2 -C7-alkoxycarbonyl groups contain, aside from the carbonyl group, one of the above mentioned alkoxy groups, especially C^-Cg-alkoxy groups. Preferred alkoxycarbonyl groups are the methoxycarbonyl- , ethoxycarbonyl- , isopropoxycarbonyl- , iεobutoxycarbonyl- and tert-butoxycarbonyl groups. Aside from the oxygen atom, alkoxycarbonyloxy groups preferably contain one of the above mentioned C2~C 7 -alkoxy- carbonyl residues. Among preferred alkoxycarbonyl groups are the methoxycarbonyloxy- , ethoxycarbonyloxy- , isopropoxycarbonylox - , isobutoxycarbonyloxy- and tert- butoxycarbonyl groups as well as allyloxycarbonyloxy groups . Aside from the carbonyl group, alkylaminocarbonyl, especially C2-C7-alkylaminocarbonyl and dialkylaminocarbonyl groups, preferably C 3 -C 13 -dialkylaminocarbonyl groups, contain an alkylamino- and/or dialkylamino residue whose alkyl groups correspond especially to the C^-Cg-alkyl groups of the above description. Preferred groups are the dimethylaminocarbonyl- , diethylaminocarbonyl- and diisopropylamino-carbonyl groups. Aside from the unsubstituted amino group, the amino group of the Formula NR 5 R 6 is one of the below mentioned alkylamino groups, especially C 3 _-Cg-alkylar-u.n0 groups and/or dialkylamino groups, especially di- (C^-Cg-alkyl) amino groups. Alkylamino especially contains one of the above mentioned Cj_ - Cg-alkyl groups. Preferred groups are the methylamino- , ethyla ino-, propylamino- , isopropylamino- , butylamino- , and the tert-butylamino groups. The preferred di- (C_ ] _-C -alkyl) amino residue carries two of the same or different of the above mentioned C_ L -Cg-alkyl groups on the nitrogen atom. Preferred groups are the dimethylamino- , diethylamino- , dipropylamino- , diisopropylamino- , isopropyl-, methylamino- , dibutylamino- or tert-butylmethylamino groups. Acyl, especially C ] _-Cg-acyl, signifies the residue of an aliphatic saturated or unsaturated, straight chained, branched or cyclic carboxylic acid. Preferred acyl residues are formyl-, acetyl-, propionyl-, acryloyl-, butyryl-, isobutyryl-, methacryloyl- , cyclopropylcarbonyl- , pentanoyl-, pivaloyl-, cyclobutylcarbonyl- , hexanoyl- and dimethylacryloyl groups. Alkanesulfonyl, especially C;__-Cg-alkanesulfonyl is preferably the methanesulfonyl- , ethanesulfonyl- , propanesulfonyl- , butanesulfonyl- , pentanesulfonyl- or hexanesulfonyl groups. Saturated or unsaturated, preferably four- to eight-membered heterocycles with one or two hetero-atoms, are for example azetidine, tetrahydrofuran, tetrahydrothiophene, pyrrolidine, tetrahydropyran, tetrahydropyridine, piperidine, tetra- hydroazepine, hexahydroazepine, octahydroazocine, pyrazolidine, piperazine, morpholine, thiomorpholine, thiomorpholin-1, 1-dioxide, hexahydrodiazepine or hexahydrooxazepine . Preferred monocyclic aromatic five- or six-membered heterocycles with one to three hetero-atoms are for example furyl, thienyl, pyrrolyl , oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, imidazolyl, pyrazolyl, oxadiazolyl, thiadiazolyl, triazolyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl or triazinyl. Anellated bi- and tricyclic aromatic or partially hydrated carbocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring are preferably benzocyclobutyl, indanyl, indenyl, naphthyl , dihydronaphthyl , tetrahydronaphthyl, biphenylenyl, fluoroenyl, anthryl, dihydroanthryl , phenanthryl, dihydrophenanthryl , dibenzocycloheptenyl, dihydrodibenzocycloheptenyl, dihydrodibenzocyclooctenyl or tetrahydrodibenzocyclooctenyl . Their mono- or dioxo- derivates, i.e. for example the residues of indanone, tetralone, anthrone, anthraquinone, fluoroenone, phenanthrone, dibenzocycloheptenone, dihydrodibenzo- cycloheptenone or tetrahydrodibenzocyclooctenone are also to be understood as partially hydrated carbocyclic ring systems. Anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring are, for example, imidazothiazolyl , benzofuryl, dihydrobenzofuryl, benzothienyl , dihydrobenzothienyl, indolyl, indolinyl, isoindolinyl, benzimidazolyl, indazolyl, benzooxazolyl, benzoisoxazolyl , benzothiazolyl, benzoisothiazolyl, benzofurazanyl, benzothiadiazolyl, benzotriazolyl, oxazolopyridyl, thiazolopyridyl, isothiazolopyridyl, imidazopyridyl, pyrazolopyridyl , thienopyrimidinyl , chromanyl, benzopyranyl , quinolyl, isoquinolyl, dihydroquinolyl , tetrahydroquinolyl , benzodioxanyl, quinoxalinyl, quinazolinyl, naphthyridinyl , carbazolyl, tetrahydrocarbazolyl, pyridoindolyl , acridinyl, phenanthridinyl , dihydrophenanthridinyl , dibenzoiso- quinolinyl, dihydrodibenzoisoquinolinyl , phenothiazinyl , dihydrodibenzooxepinyl , benzocycloheptathienyl , dihydrothienobenzothiepinyl , dihydrodibenzothiepinyl , octahydrodibenzothiepinyl, dibenzoazepinyl , dihydrodi- benzoazepinyl, octahydrodibenzoazepinyl, benzocyclohepta- pyridyl, dihydrobenzocycloheptapyridyl, pyridobenzoazepinyl , dihydropyridobenzoazepinyl , dihydropyridobenzodiazepinyl , dihydrodibenzooxazepinyl , dihydropyridobenzooxepinyl , dihydropyridobenzooxazepinyl, dihydrodibenzothiazepinyl or dihydropyridobenzothiazepinyl . Furthermore, their mono- or dioxo-derivates and/or optionally their possible tautomers are also to be understood as partially hydrated heterocyclic ring systems, i.e. for example the residues of indolinone, isatin, of benzooxazolone and/or its tautomer hydroxybenzooxazole, of benzisoxazolone, benzothiazolone, benzoisothiazolone and benzimidazolone and/or their corresponding tautomers, hydroxybenzoisoxazole, hydroxybenzothiazole, hydroxybenzoisothiazole and hydroxy- benzimidazole, as well as indazolinone, of oxazolopyridinones, thiazolopyridinones, pyrazolopyridinones and imidazopyridinones and/or their corresponding tautomers hydroxyoxazolopyridine , hydroxythiazolopyridine , hydroxypyrazolopyridine and hydroxyimidazopyridine, the residues from the series chromanone, chromone, quinolinone, dihydroquinolinone, tetrahydrocarbazolone, acridone, phenanthridone, benzoisoquinolinone, dihydrodibenzoxepinones, benzocycloheptathiophenones , dihydrothienobenzothiepinones , dihydrodibenzothiepinones , dihydrodibenzoazepinones , benzocycloheptapyridinones , dihydropyridobenzoazepinones , dihydropyridobenzodiazepinones , dihydropyridobenzooxazepinones , dihydrodibenzothiazepinones and of dihydropyridobenzothiazepinones . Saturated and unsaturated monocyclic, four- to eigh -membered heterocycles (as the group —NR 13 R 15 ) which, aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from N and/or S and/or 0,are for example azetidine, pyrrolidine, piperidine, (1H)- tetrahydropyridine, hexahydroazepine, (1H) -tetrahydroazepine, octahydroazocine, pyrazolidine, piperazine, hexahydrodiazepine, morpholine, hexahydroxazepine, thiomorpholine or thiomorpholin- 1, 1-dioxide . Saturated or unsaturated bi- or tricyclic, anellated or bridged heterocycles with 8 to 16 ring atoms (as the group —NR 13 R 15 ) which, aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms, selected from N and/or S and/or O, are for example 5-aza- bicyclo [2.1.1] hexane, 2-aza-bicyclo [2.2.1] heptane, 7-aza- bicyclo [2.2.1] heptane, 2 , 5-diaza-bicyclo [2. 2 .1] heptane, 2- aza-bicyclo [2.2.2] octane, 8-aza-bicyclo [3.2.1] octane, 2,5- diaza-bicyclo [2.2.2] octane, 9-aza-bicyclo [3.3.1] nonane, indoline, isoindoline, (1H) -dihydroquinoline, (1H)- tetrahydroquinoline, (2H) -tetrahydroisoquinoline, (1H) - tetrahydroquinoxaline, (4H) -dihydrobenzoxazine, (4H) - dihydrobenothiazine, (1H) -tetrahydrobenzo [b] azepine, (1H) - tetrahydrobenzo [c] azepine, (1H) -tetrahydrobenzo [d] azepine, (5H) -tetrahydrobenzo [b] oxazepine, (5H) - tetrahydrobenzo [b] thiazepine , 1,2,3,4-tetrahydro-9H- pyrido [3, 4-b] indole, (10H) -dihydroacridine, (10H)- dihydrophenanthridine , 1,2,3,4- tetrahydroacridanone , ( 10H) - phenoxazine, (10H) -phenothiazine, (5H) -dibenzazepine, (5H) - dihydrodibenzazepine, (5H) -octahydrodibenzazepine, dihydrobenzo [d, e] isoquinoline, (5H) -dihydrodibenzodiazepine, (5H) -benzo [b] pyrido [f] azepine, (5H) -dihydrobenzo [b]pyrido- [f] azepine (IIH) -dihydrodibenzo [b, e] oxazepine, (11H)- dihydrodibenzo [b, e] thiazepine, (10H) -dihydrodibenzo [b, f] oxazepine, (10H) -dihydrodibenzo [b, f] thiazepine, (5H) - tetrahydrodibenzazocine, (IIH) -dihydrobenzo [e] pyrido [b] -1,4- diazepin-6-one, (IIH) -di-hydrobenzo [b] pyrido [e] -1, 4-diazepin- 5-one . Concretely, the invention relates to new piperazinyl - substituted compounds of the general Formula (I) wherein R 1 is selected from hydrogen, hydroxy, halogen, cyano, aminocarbonyl, carboxy, saturated, single or several-fold unsaturated, branched or straight chained or cyclic hydrocarbon residues such as alkyl, alkenyl, alkinyl or cycloalkyl, aryl such as phenyl or heteroaryl such as pyridyl, alkoxy, cycloalkyloxy, alkenyloxy or alkinyloxy or aralkyloxy such as the benzyloxy group, alkoxycarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl , alkanoyloxy, alkoxycarbonyloxy, alkylthio, cycloalkylthio, alkenylthio, alkinylthio, aryloxy such as phenoxy, heteroaryloxy such as pyridyloxy, arylthio such as phenylthio, heteroarylthio such as pyridylthio, trifluoromethyl , hydroxyalkyl , NR 5 R 6 , wherein R 5 and R 6 are selected independent of each other from hydrogen, saturated or unsaturated hydrocarbon residues such as alkyl, alkenyl, alkinyl, or aryl such as phenyl and aralkyl such as benzyl ; R 2 is selected from hydrogen, halogen, cyano, saturated hydrocarbon residues such as alkyl, or halogenated hydrocarbon residues such as trifluoromethyl, hydroxy, alkoxy, aralkyloxy residues such as benzyloxy, as well as alkanoyloxy, whereby R 1 and R 2 , in the case that they are immediately adjacent to each other, optionally form a bridge which is selected from -(CH 2 ) 4 - and -(CH=CH) 2 - and -CH 2 0-CR 7 R 8 -0- , wherein R 7 and R 8 are selected independently of each other from hydrogen and alkyl residues; R 3 is selected from hydrogen, halogen, saturated hydrocarbon residues such as alkyl, or halogenated hydrocarbon residues such as trifluoromethyl, or hydroxyalkyl ; R 4 is selected from hydrogen, hydroxy, or single or several-fold unsaturated, branched or straight chained or cyclic hydrocarbon residues such as alkyl, alkenyl, alkinyl or cycloalkyl, alkoxy and aralkyloxy such as benzyloxy; k is 0 or 1; A is selected from Alkylene which is optionally substituted one to threefold by straight chained or branched chained hydrocarbon residues such as alkyl, hydroxy, alkoxy, halogen such as fluorine, or aryl such as phenyl , Alkylene, wherein a methylene unit is isosterically replaced by 0, S, NR 9 , CO, SO or S0 2 whereby, with the exception of CO, the isosteric substitution cannot be adjacent to the amide group and, in NR 9 , the residue R 9 is selected from hydrogen, alkyl, alkenyl, alkinyl, acyl or alkanesulfonyl ; Cycloalkylene such as 1, 2-cyclopropylene; Alkenylene which is optionally substituted one to threefold by alkyl, hydroxy, alkoxy, fluorine, cyano or aryl such as phenyl ; Alkadienylene, which is optionally substituted once or twice by alkyl, fluorine, cyano or aryl such as phenyl, 1, 3 , 5-hexatrienylene, which is optionally substituted by alkyl, fluorine, cyano or aryl such as phenyl, and ethinylene,- is selected from alkylene, which is optionally substituted once or twice by alkyl, hydroxy, or alkoxy; alkenylene, which is optionally substituted once or twice by alkyl, hydroxy, or alkoxy,- alkinylene, which is optionally substituted once or twice by alkyl, hydroxy, or alkoxy, as well as alkylene, alkenylene or alkinylene, wherein one to three methylene units is each isosterically replaced by 0, S, NR 10 , CO, SO or S0 2 , wherein t 10 has the same meaning as R 9 but is selected independently thereof; E whereby q is 1, 2 or 3; R 11 is selected from hydrogen, alkyl, hydroxy, hydroxymethyl , carboxy, or alkoxycarbonyl and R 12 is selected from hydrogen, alkyl or an oxo group immediately adjacent to a nitrogen atom or R 11 and R 12 , optionally together, form an alkylene bridge under formation of a bicyclic ring system; G is selected from Gl, G2 , G3 , G4 or G5 , wherein G 1 is (CH 2 ) r (CR 14 R 15 ) S R 13 (Gl) whereby r has the meaning 0 to 3 , s is 0 or 1 ; R 13 is selected from hydrogen, alkyl, alkenyl, alkinyl, cycloalkyl; saturated or unsaturated, four to eight-membered heterocycles which can contain one or two hetero-atoms that are selected from N and/or S and/or O; benzyl , phenyl ; monocyclic aromatic five- or six-membered heterocycles which can contain 1 to 3 hetero-atoms that are selected from N and/or S and/or 0 and are either directly bound or bound over a methelyene group ; anellated bi- and tricyclic aromatic or partially hydrated carbocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, whereby the bond can occur either over an aromatic or a hydrated ring and either directly or over a methylene group; anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, whereby one to three ring atoms can be selected from N and/or S and/or 0 and the bond can occur either over an aromatic or a hydrated ring and either directly or over a methylene group; R 14 has the same meaning as R- 1 - 3 but is selected independently thereof ; R 15 is selected from hydrogen, hydroxy, C 1 -C 3 -alkyl, aralkyl such as benzyl or aryl such as phenyl, monocyclic aromatic five or six-membered heterocycles, which can contain one to three hetero-atoms selected from the group N and/or S and/or 0 and are either bound directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated carbocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from N and/or S and/or O and the linkage can occur either over an aromatic ring or a hydrated ring and either directly or over a methylene group, with the exception of compounds in which G has the meaning (CH 2 ) r (CR 14 R 15 )c R 13 (Gl) in the case that the following substitutents are simultaneously signify R13 pyridyl or (optionally halogen-, alkyl-, alkoxy- or Trifluoromethyl -substituted) phenyl , R^ 4 hydrogen or (phenyl optionally substituted with halogen-, alkyl-, alkoxy- or Trifluoro methyl, R- 1 - 5 is hydrogen, and A represents alkylene, optionally substituted ethenylene or butadienylene, D alkylene or alkenylene as well as E piperazine or homopiperazine and s = 1; G 2 is selected from c (CH 2 ) r (CR 14 R 15 ) C >13 II o (G2a) or -C (CH 2 ) r NR 1 3 R 15 0 (G2b) whereby r and s as well as the substitutents R 13 to R 15 can have the above meaning, or the grouping NR 13 R 15 can also be a nitrogen heterocycle bound over the nitrogen atom selected from saturated or unsaturated monocyclic, four to eight- membered heterocycles, which , aside from the essential nitrogen atom, can still optionally contain one or two further hetero-atoms selected from N and/or S and/or O, or saturated or unsaturated bi- or tricyclic, anellated or bridged heterocycles with 8 to 16 ring atoms, that aside from the essential nitrogen atom, can optionally still contain one or two further hetero-atoms that are selected from N and/or S and/or 0; G 3 has the meaning S0 2 (CH 2 ) r R 13 (G3) wherein r and R-*- 3 have the above definition, G 4 has the meaning 1 V Ar (G4) whereby Ar 1 and Ar 2 can be selected independently from each other from phenyl, pyridyl or naphthyl ; has the meaning COR 16 (G5 ; whereby R 1 ^ is selected from trifluoromethyl, alkoxy, alkenyloxy, and aralkyloxy such as benzyloxy, whereby aromatic ring systems in the substitutents R 1 , R 2 , R 4 , R 5 , R 6 , R 13 , R 14 , R 15 , R 16 , Ar 1 and Ar 2 and/or in the ring system NR 13 R 15 can be substituted independently from each other by one to three of the same or different groups selected from halogen, cyano, alkyl, halogen alkyl such as trifluoromethyl, cycloalkyl, aryl such as phenyl, arylalkyl such as benzyl; hydroxy, hydroxy alkyl, alkoxy, alkoxy entirely or partially substituted by fluorine, aralkyloxy such as benzyloxy, aryloxy such as phenoxy; mercapto, alkylthio, carboxy, carboxyalkyl , carboxyalkenyl , alkoxycarbonyl , aralkyloxycarbonyl such as benzyloxycarbonyl , nitro, amino, monoalkylamino, dialkylamino and in the case of two adjacent residues on the aromatic ring, also methylendioxy, and whereby alkyl-, alkenyl- and cycloalkyl residues in the groups G 1 , G 2 and G 3 can be substituted by one or two of the same or different groups which are selected from hydroxy, carboxy, alkoxycarbonyl, aralkyloxycarbonyl such as benzyloxycarbonyl, amino, monoalkylamino and dialkylamino; their cis- and trans-isomers, E- and Z-isomers, especially in case that A is a cyclopropane ring or D contains one or more double bonds, including the enantiomers, diastereomers and other isomers as well as their racemic or non-racemic mixtures and the corresponding endo- and exo-isomers for the case that the ring system E is bicyclic; their tautomers; their acid addition salts including their hydrates and solvates . Furthermore, the invention relates to preferred pyridylalkane, pyridylalkene and pyridylalkine carboxamides of the Formula (I) wherein the substitutents have the following meanings is selected from hydrogen, halogen, cyano, Ci-Cg-alkyl, C3-C5-alkenyl, C2~Cg-alkinyl, trifluoromethyl, C3-C8-cycloalkyl, C_]_-Cg- hydroxyalkyl , hydroxy, C_L-Cg-alkoxy, C3-Cg-alkenyloxy, C3-Cg-alkinyloxy, benzyloxy, C;__-C7-alkanoyloxy, C2-C7- alkoxycarbonyloxy, C1-C5 -alkylthio, C3-Cg-alkenylthio, C3-Cg-alkinylthio, C3-Cg-cycloalkyloxy, C3-Cg- cycloalkylthio, C2 -C7-alkoxycarbonyl , aminocarbonyl, C 2 - C7-alkylaminocarbonyl, C3-C ] _3-dialkylaminocarbonyl, carboxy, phenyl, phenoxy, phenylthio, pyridyloxy, pyridylthio, and NR 5 R 6 , wherein R 5 and R 6 are selected independently of each other from hydrogen, C^-Cg-alkyl, C3 -Cg-alkenyl , C3 -Cg-alkinyl , benzyl and phenyl ; R 2 is selected from hydrogen, halogen, cyano, C_ j _-Cg-alkyl, trifluoromethyl, hydroxy, C_L-Cg -alkoxy, benzyloxy and Cι-C7-alkanoyloxy; R 1 and R 2 , if adjacent, optionally form a bridge selected from -(CH 2 )4- and -(CH=CH) 2 - or -CH 2 0-CR 7 R 8 -0- , wherein R 7 and R 8 are selected independently from each other from hydrogen and C_j_-Cg-alkyl ; R 3 is selected from hydrogen, halogen, C_ι_-Cg-alkyl, trifluoromethyl and Cτ_-Cg-hydroxyalkyl ; R 4 is selected from hydrogen, C_ι_-Cg-alkyl, C3~Cg-alkenyl, C3 -C -alkinyl , 03- Cg- cycloalkyl, hydroxy, C_L-Cg-alkoxy and benzyloxy; : is 0 or 1 , -. is selected from C_ ] _-Cg-alkylene, optionally substituted one to three-fold by C1-C3-alkyl, hydroxy, C1-C3-alkoxy, fluorine, or phenyl , C2-Cg-alkylene, in which a methylene unit is isosterically replaced by 0, S, NR 9 , CO, SO or S0 2 , whereby, with the exception of CO, the isosteric substitution cannot be adjacent to the amide group and, in NR 9 , the residue R9 is selected from hydrogen, C_j_-Cg- alkyl, C3-Cg-alkenyl , C 3 -Cg-alkinyl , Ci-Cg-acyl or C 1 - Cg-alkanesulfonyl, 1,2-cyclopropylene, C2~Cg -Alkenylene, optionally substituted once to threefold by C1-C3-alkyl, hydroxy, 1-C2 -alkoxy, fluorine, cyano or phenyl, C4-Cg-alkadienylene, optionally substituted once or twice by C]_-C3-alkyl, fluorine, cyano or phenyl; 1, 3 , 5-hexatrienylene, optionally substituted by C_|_-C3- alkyl, fluorine, cyano or phenyl, and ethinylene D is selected from c 2" c 10" alk y lene ' optionally substituted once or twice by C_L-Cg-alkyl, hydroxy, or C_L-C -alkoxy; c 4 _c 10" alken y lene ' optionally substituted once or twice by C_L~Cg-alkyl, hydroxy, or C_ ] _-Cg-alkoxy; C4-C_ ] _o-alkinylene, optionally substituted once or twice by C^-Cg-alkyl, hydroxy, or C;__-Cg-alkoxy; as well as C2-C 10 -alkylene, C4-C_j_o _a l ken y lene or C4-C 1 o-alkinylene, in which one to three methylene units are isosterically replaced by 0, S, NR 10 , CO, SO or S0 2 , whereby R 10 has the same meaning as R , but is selected independently thereof ; signifies whereby q has the meaning 1 , 2 or 3 ; R 11 is selected from hydrogen, C_ ] _-Cg-alkyl, hydroxy, hydroxymethyl , carboxy, or C2-C7-alkoxycarbonyl and R^- 2 is selected from hydrogen, C_L-Cg-alkyl or an oxo group adjacent to a nitrogen atom, or R 11 and R 12 optionally together, form a C1-C3-alkylene bridge under formation of a bicyclic ring system; G is selected from Gl, G2 , G3 , G4 or G5 , whereby represents (CH 2 ) r (CR R ) s R (Q1) r has the meaning 0 to 3 , s is 0 or 1 and R 13 is selected from hydrogen, C_ [ _-Cg-alkyl, C 3 -Cg-alkenyl , C 3 ~C -alkinyl, C 3 - Cg-cycloalkyl ; saturated or unsaturated, four to eight-membered heterocycles, which can contain one or two hetero-atoms that are selected from N and/or S and/or 0; benzyl , phenyl ; monocyclic aromatic five or six-membered heterocycles, which can contain one to three hetero-atoms selected from the group N and/or S and/or O and are either bound directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated carbocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from N and/or S and/or 0 and the linkage can occur either over an aromatic ring or a hydrated ring and either directly or over a methylene group, R 14 has the same meaning as R 13 , but is selected independently thereof ; ^15 is selected from hydrogen, hydroxy, methyl, benzyl, phenyl, monocyclic aromatic five or six-membered heterocycles, which can contain one to three hetero-atoms from the group N and/or S and/or 0 and are either bound directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated carbocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from N and/or S and/or 0 and the linkage can occur either over an aromatic ring or a hydrated ring and either directly or over a methylene group, whereby G in the form of G 1 cannot have the meaning (CH 2 ) r (CR 14 R 15 ) R 13 (Gl] in the case that the following substitutions simultaneously signify R1 3 pyridyl or (optionally halogen-, alkyl-, alkoxy- or Trifluoromethyl- substituted) phenyl , R 14 hydrogen or (phenyl optionally substituted with halogen-, alkyl-, alkoxy- or trifluoro methyl, R 15 is hydrogen, and A represents alkylene, optionally substituted ethenylene or butadienylene, D alkylene or alkenylene as well as E piperazine or homopiperazine and S = 1; is selected from C (CH 2 ) r (CR 14 R 15 )_ R 1 : II o (G2a) or C (CH 2 ) r NR 13 R 15 ° (G2b) whereby r and s as well as the substitutents R-*- 3 to R- 1 - 5 can have the above meaning, or the grouping NR 13 R 15 can also be a nitrogen heterocycle bound over the nitrogen atom selected from saturated or unsaturated monocyclic, four to eight- membered heterocycles, which , aside from the essential nitrogen atom, can optionally still contain one or two further hetero-atoms selected from N and/or S and/or O, or saturated or unsaturated bi- or tricyclic, anellated or bridged heterocycles with 8 to 16 ring atoms, that aside from the essential nitrogen atom, can optionally still contain one or two further hetero-atoms that are selected from N and/or S and/or 0; G 3 has the meaning S0 2 (CH 2 ) r R 13 (G3) wherein r and R 13 have the above definition, G 4 has the meaning 1 ° *P 2 (G4 ) whereby Ar 1 and Ar 2 can be selected independently from each other from phenyl, pyridyl or naphthyl; G 5 has the meaning COR 16 (G5 ) R- l - is selected from trifluoromethyl, C 1 -Cg-alkoxy, C3-Cg-alkenyloxy, and benzyloxy, whereby aromatic ring systems in the substitutents are R 1 , R 2 , R 4 , R 5 , R 6 , R 13 , R 14 , R 15 , R 16 , Ar 1 and Ar 2 and/or in the ring system NR 13 R 15 can be substituted independently from each other by one to three of the same or different groups selected from halogen, cyano, C_ L -Cg-alkyl, trifluoromethyl, C 3 -C 3 - cycloalkyl, phenyl, benzyl, hydroxy, C_ L -Cg-hydroxyalkyl, ^ - Cg-alkoxy, C 1 -Cg-alkoxy entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, C_ L -Cg-alkylthio, carboxy, C 2 -C 7 -carbox alkyl, C 2 -C 7 -carboxyalkenyl, C 2 -C 7 - alkoxycarbonyl , benzyloxycarbonyl, nitro, amino, mono-C_ L -Cg- alkylamino, di- (C_ L -Cg-alkyl) -amino and, methylene dioxide for two adjacent residues on the aromatic ring, and whereby alkyl-, alkenyl- and cycloalkyl residues in the groups G 1 , G 2 and G 3 can be substituted by one or two of the same or different groups which are selected from hydroxy, carboxy, C 2 -C 7 -alkoxycarbonyl , benzyloxycarbonyl , amino, mono-C_ | _-Cg-alkylamino and di- (Cτ_-Cg-alkyl-amino) ; their cis- and trans-isomers, E- and Z-isomers, especially in case that A is a cyclopropane ring or D contains one or more double bonds, including the enantiomers, diastereomers and other isomers as well as their racemic or non-racemic mixtures and the corresponding endo- and exo-isomers for the case that the ring system E is bicyclic; their tautomers; their acid addition salts including their hydrates and solvates . According to a further preferred embodiment, the invention relates to compounds of the general Formula (I) , whereby R 1 is selected from hydrogen, halogen, cyano, C_ι_-Cg-alkyl, trifluoromethyl , C 3 -Cg-cycloalkyl, C 1 -Cg-hydroxyalkyl , hydroxy, C_|_-C 4 - alkoxy, benzyloxy, C_|_-C 4 -alkylthio, C_]_-C5-alkanoyloxy, C_ι_-C 4 -alkylthio, C2-C 5 -alkoxycarbonyl , aminocarbonyl, c 2 ~ c 5"alkylaminocarbonyl , C3 -C -dialkylaminocarbonyl , carboxy, phenyl, phenoxy, phenylthio, pyridyloxy, and NR 5 R 6 , whereby R 5 and R 6 are selected independently from each other from hydrogen and C_L-Cg- lkyl; R 2 is selected from hydrogen, halogen, cyano, C^-C -alkyl, trifluoromethyl , hydroxy, C_]_-C 4 -alkoxy; R 3 is selected from hydrogen, halogen and C;__-Cg-alkyl; R 4 is selected from hydrogen, C_ι_-Cg-alkyl, C 3 -Cg-alkenyl , C 3 -Cg-cycloalkyl , hydroxy, C_[_-Cg-alkoxy and benzyloxy; k has the meaning 0 or 1, A is selected from C;__-Cg-alkylene, optionally substituted one to three-fold by C_j_-C 3 -alkyl, hydroxy, fluorine, or phenyl, C 2 ~Cg-alkylene, in which a methylene unit is isosterically replaced by 0, S, NR 9 , CO, SO or S0 2 , whereby, with the exception of CO, the isosteric substitution cannot be adjacent to the amide group and, in NR 9 , the residue R9 is selected from hydrogen, C^-Cg- alkyl, C_ L ~Cg-acyl or methanesulfonyl ; 1,2-cyclopropylene, C2~Cg-Alkenylene, optionally substituted once to threefold by C 1 -C3 -alkyl, hydroxy, fluorine, cyano or phenyl, C 4 -Cg-alkadienylene, optionally substituted once to twofold by C 1 -C 3 -alkyl, fluorine, cyano or phenyl; 1, 3, 5-hexatrienylene, optionally substituted by C1-C3- alkyl, fluorine, cyano, and ethinylene D is selected from C2-Cιo~alkylene, optionally substituted once or twice by C1-C3 -alkyl or hydroxy; C4-Cιo~alkenylene, optionally substituted once or twice by C1-C3-alkyl or hydroxy; C4-Cη_o-alkinylene, optionally substituted once or twice by C; ] _-C3 -alkyl or hydroxy; as well as C2-C 1Q -alkylene, C4-C10-alkenylene or C4-C 1 Q-alkinylene, in which one to three methylene units is each isosterically replaced by 0, S, NR 10 , CO, SO or S0 2 , whereby R 10 has the same meaning as R 9 , but is selected independently thereof ; E signifies ) whereby q has the meaning 1 , 2 or 3 ; R 11 is selected from hydrogen, C 2. -C 3 -alkyl, hydroxy, hydroxymethyl , carboxy, or C 2 -C 7 -alkoxycarbonyl and 1 R is selected from hydrogen or an oxo group adjacent to a nitrogen atom or R 11 and R 12 , optionally together, form a C 1 -C 3 -alkylene bridge under formation of a bicyclic ring system; G is selected from Gl, G2 , G3 , G4 or G5 , whereby G 1 represents — ( « ■ **— (CR1«R«).— RM (G1) r has the meaning 0 to 2 , s is 0 or 1 and R 13 is selected from hydrogen, C^-Cg-alkyl, C3-C5-alkenyl, C 3 -C5-alkinyl, C 3 - Cg-cycloalkyl; benzyl, phenyl; monocyclic aromatic five or six-membered heterocycles, which can contain one to three hetero-atoms selected from the group N and/or S and/or 0 and are either bound directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated carbocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from N and/or S and/or 0 and the linkage can occur either over an aromatic ring or a hydrated ring and either directly or over a methylene group, R^ 4 has the same meaning as R 13 , but is selected independently thereof ; R 15 is selected from hydrogen, hydroxy, methyl, benzyl, phenyl; monocyclic aromatic five or six-membered heterocycles, which can contain one to three hetero-atoms selected from the group N and/or S and/or 0 and are either bound directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated carbocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from N and/or S and/or 0 and the linkage can occur either over an aromatic ring or a hydrated ring and either directly or over a methylene group; G 2 is selected from C (CH 2 ) r (CR 14 R 15 ) S R 13 II o (G2a) or C (CH 2 ) r NR 1 R 15 ° (G2b) whereby r and s as well as the substitutents R 13 to R 15 can have the above meaning, or the grouping NR 13 R 15 can also be a nitrogen heterocycle bound over the nitrogen atom selected from saturated or unsaturated monocyclic, four to eight- membered heterocycles, which, aside from the essential nitrogen atom, can optionally still contain one or two further hetero-atoms selected from N and/or S and/or O, or saturated or unsaturated bi- or tricyclic, anellated or bridged heterocycles with 8 to 16 ring atoms, that aside from the essential nitrogen atom, can optionally still contain one or two further hetero-atoms that are selected from N and/or S and/or 0; G 3 has the meaning S0 2 (CH 2 ) r R 13 (G3) wherein r and R 13 have the above definition, G 4 has the meaning \ ^Ar 1 ° *P 2 (G4 ) whereby Ar 1 and Ar 2 can be selected independently from each other from phenyl, pyridyl or naphthyl; G 5 has the meaning COR 16 (G5) R 16 is selected from trifluoromethyl, C^-Cg-alkoxy, C 3 ~Cg-alkenyloxy, and benzyloxy, whereby aromatic ring systems in the substitutents are R 1 , R 2 , R 4 , R 5 , R 6 , R 13 , R 14 , R 15 , R 16 , Ar 1 and Ar 2 and/or in the ring system NR 13 R 15 can be substituted independently from each other by one to three of the same or different groups selected from halogen, cyano, C^-Cg-alkyl, trifluoromethyl, C 3 -C 3 - cycloalkyl, phenyl, benzyl, hydroxy, C ] _-Cg-hydroxyalkyl, ^ - Cg-alkoxy, C^-Cg-alkoxy entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, C^-Cg-alkylthio, carboxy, C2-C 7 -carboxyalkyl, C 2 -C 7 -carboxyalkenyl , C 2 -C 7 - alkoxycarbonyl , benzyloxycarbonyl, nitro, amino, mono-C^-Cg- alkylamino, di- (C^-Cg-alkyl) -amino and, methylene dioxide in the case of two adjacent residues on the aromatic ring, whereby alkyl-, alkenyl- and cycloalkyl residues in the groups G 1 , G 2 and G 3 can be substituted by one or two of the same or different groups which are selected from hydroxy, carboxy, C2-C 7 -alkoxycarbonyl, benzyloxycarbonyl , amino, mono-Ci-Cg-alkylamino and di- (C^Cg-alkyl-amino) . According to a further embodiment, the invention especially relates to compounds of the general Formula (1) , wherein R 1 is selected from hydrogen, halogen, cyano, methyl, ethyl, trifluoromethyl, hydroxy, C 1 -C4-alkoxy, benzyloxy, C^- C5-alkanoyloxy, methylthio, ethylthio, methoxycarbonyl , tert-butoxycarbonyl aminocarbonyl, carboxy, phenoxy, and phenylthio R 2 is selected from hydrogen, halogen, trifluoromethyl, hydroxy; R 3 is selected from hydrogen, halogen; R 4 is selected from hydrogen, Cη_-C3 -alkyl, allyl, hydroxy and C ! -C 3 -alkoxy; k is 0 or 1, A is selected from C^-Cg-alkylene, optionally substituted once or twice by C 1 -C 3 -alkyl, hydroxy or fluorine; C 2 ~Cg-alkylene, in which a methylene unit is isosterically replaced by 0, S, NR 9 , CO, SO or SO2 , whereby, with the exception of CO, the isosteric substitution cannot be adjacent to the amide group, C 2 ~Cg-alkylene, optionally substituted once or twice by c l ~ c 3 alkyl, hydroxy and/or fluorine; C4~Cg-alkadienylene, optionally substituted by C 1 -C3- alkyl or one or two fluorine atoms; 1, 3 , 5-hexatrienylene, optionally substituted by fluorine; D is selected from C2-Cg-alkylene, optionally substituted once or twice by methyl or hydroxy; C 4 -C 3 -alkenylene, optionally substituted once or twice by methyl or hydroxy; C 4 -Cg-alkinylene, optionally substituted once or twice by methyl or hydroxy; and C2-C 3 -alkylene, C 4 -C -alkenylene or C 4 -Cg-alkinylene, wherein one to three methylene units are each isosterically replaced by O, S, NH, N(CH 3 ) N(COCH 3 ), N(S0 2 CH 3 ), CO, SO or S0 2 , whereby E has the meaning whereby q is 1 or 2 ; R 11 is selected from hydrogen, C 1 -C3-alkyl, hydroxymethyl, or carboxy, and R is selected from hydrogen or an oxo group adjacent to a nitrogen atom G is selected from Gl, G2 , G3 , G4 or G5 , whereby Gl (CH 2 ) r (CR14R15 )S R 13 ^ represents r is 0 to 2 and, s is 0 or 1 ; and R- 1 - 3 is selected from hydrogen, C ] _-Cg -alkyl, C3~Cg-cycloalkyl; benzyl, phenyl; benzocyclobutyl , indanyl , indenyl , oxoindanyl , naphthyl , dihydronaphthyl , tetrahydronaphthyl , oxotetrahydron- aphthyl, biphenylenyl, fluorenyl, oxofluorenyl , anthryl, dihydroanthryl , oxodihydroanthryl , dioxodihydroanthryl , phenanthryl , dihydrophenanthryl , oxodihydrophenanthryl , dibenzocycloheptenyl , oxodibenzocycloheptenyl , dihydrodibenzocycloheptenyl , oxodihydrodibenzocyclo- heptenyl, dihydrodibenzocyclooctenyl, tetrahydrodibenzo- cyclooctenyl or oxotetrahydrodibenzocyclooctenyl bound directly or over a methylene group; furyl, thienyl, pyrrolyl , oxazolyl, isoxazolyl, thiazolyl, iso-thiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, triazinyl, imidazothiazolyl, benzofuryl, dihydrobenzofuryl, benzothienyl, dihydrobenzothienyl , indolyl, indolinyl, isoindolinyl, oxoindolinyl , dioxoindolinyl , benzoxazolyl, oxobenzooxazolinyl , benzoisoxazolyl, oxobenzoisoxazolinyl, benzothiazolyl, oxobenz- thiazolinyl, benzoisothiazolyl, oxobenzoisothiazolinyl, benzoimidazolyl, oxobenzoimidazolinyl, indazolyl, oxoindazolinyl, benzofurazanyl, benzothiadiazolyl, benzotriazolyl, oxazolopyridyl, oxodihydrooxazolo- pyridyl, thiazolopyridyl , oxodihydrothiazolopyridyl, isothiazolopyridyl, imidazopyridyl , oxodihydroimidazo- pyridyl, pyrazolopyridyl , oxodihydropyrazolopyridyl , thienopyrimidinyl , chromanyl, chromanonyl, benzopyranyl, chromonyl , quinoloyl , isoquinoloyl , dihydroquinolyl , oxodihydroquinolinyl , tetrahydroquinolyl , oxotetrahydroquinolinyl, benzodioxanyl , quinoxalinyl, quinazolinyl, naphthyridinyl , carbazolyl, tetrahydrocarbazolyl , oxotetrahydrocarbazolyl , pyridoindolyl , acridinyl , oxodihydroacridinyl , phenanthridinyl , dihydrophenanthridinyl , oxodihydrophenanthridinyl , dibenzoisoquinolinyl , dihydrodibenzoisoquinolinyl , oxodihydrodibenzo- isoquinolinyl, phenothiazinyl , dihydrodibenzooxepinyl , oxodihydrodibenzooxepinyl , benzocycloheptathienyl , oxobenzocycloheptathienyl , dihydrothienobenzothiepinyl , oxodihydrothienobenzothiepinyl , dihydrodibenzothiepinyl , oxodihydrodibenzothiepinyl, octahydrodibenzothiepinyl , dibenzoazepinyl , dihydrodibenzoazepinyl , oxodihydrodibenzoazepinyl, octahydrodibenzoazepinyl , benzocycloheptapyridyl , oxobenzocycloheptapyridyl , pyridobenzoazepinyl , dihydropyridobenzoazepinyl , oxodihydropyridobenzoazepinyl , dihydropyridobenzo- diazepinyl , dihydrodibenzooxazepinyl, dihydropyridobenzooxepinyl , dihydropyrid- obenzooxazepinyl , oxodihydropyridobenzooxazepinyl , dihydrodibenzothiazepinyl , oxodihydrodibenzothiazepinyl , dihydropyridobenzothiazepinyl or oxodihydropyridobenzothiazepinyl bound directly or over a methylene group; R 14 is synonymous with R 13 but is selected independent thereof ; R 15 is selected from hydroxy, methyl, benzyl, phenyl, indanyl, indenyl, naphthyl, dihydronaphthyl , tetrahydronaphthyl , furyl , thienyl, pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, triazinyl, benzofuryl, benzothienyl, indolyl, indolinyl, benzooxazolyl, benzothiazolyl, benzoimidazolyl, chromanyl, quinolyl or tetrahydroquinolyl bound directly or over a methylene grou ; is selected from C (CH 2 ) r (CR 1 1 4 4RR 1 1 5 5), S R P 13 II o (G2a) or C (CH 2 ) r NR 13 R 15 O (G2b) whereby r and s and the substituents R 13 to R- 1 - 5 can have the above meaning, or the grouping NR 13 R 15 represents the ring of azetidine bound over the nitrogen or one of the following residues: pyrrolidine, piperidine, (1H) -tetrahydropyridine, hexahydroazepine, (1H) -tetrahydroazepine, octahydroazocine, pyrazolidine, piperazine, hexahydrodiazepine, morpholine, hexahydro- oxazepine, thiomorpholine, thiomorpholin-1, 1-dioxide, of 5-aza-bicyclo- [2.1.1] hexane, 2-aza- bicyclo [2.2.1] heptane, 7-aza-bicyclo- [2.2.1] heptane, 2 , 5-diaza-bicyclo [2.2.1] heptane, 2-aza-bi- cyclo [2.2.2] octane, 8-aza-bicyclo [3.2.1] octane, 2,5- diaza-bicyclo [2.2.2] octane, 9-aza-bicyclo [3.3.1] nonane, indoline, isoindoline, (1H) -dihydroquinoline, (1H)- tetrahydroquinolin, (2H) -tetrahydroisoquinoline, (1H) - tetrahydroquinoxaline, (4H) -dihydrobenzooxazine, (4H) - dihydrobenzothiazine, (1H) -tetrahydrobenzo [b] azepine, (1H) -tetrahydrobenzo [c] azepine, (1H) -tetrahydrobenzo [d] azepine, (5H) -tetrahydrobenzo [b] ox-azepine, (5H) -tetrahydrobenzo [b] thiazepine, 1,2,3, 4-tetra-hydro- 9H-pyrido[3,4-b] indole, (10H) -dihydroacridine, (10H)- dihydrophenanthridine, 1,2,3,4-tetrahydroacridanone, (10H) -phenoxazine, (10H) -phenothiazine, (5H) - dibenzoazepine, (5H) -dihydrodibenzoazepine, (5H)- octahydrodibenzoazepine, dihydrobenzo [d, e] isoquinoline, (5H) -dihydrodibenzodiazepine, (5H) -benzo [b]pyrido- [f] azepine, (5H) -Dihydrobenzo [b]pyri-do [f] azepine, (IIH) -Dihydrodibenzo [b, e] oxazepine, (IIH) - dihydrodibenzo [b, e] thiazepine, (10H) -dihydrodibenzo [b, f] -oxazepine, (10H) -dihydrodibenzo [b, f] thiazepine, (5H) -tetra-hydrodibenzoazocine, (IIH) - dihydrobenzo [e] pyrido [b] -1, 4-diazepin-6-one or (11H)- Dihydrobenzo [b] pyrido [e] -1, 4-diazepin-5-one . G 3 S0 2 (CH 2 ) r R 13 (G3) wherein r and R-*- 3 have the above definition, G 4 has the meaning whereby Ar 1 and Ar 2 are selected independently from each other from phenyl , pyridyl or naphthyl ; G5 has the meaning R^-6 is selected from trifluoromethyl, C^-Cg-alkoxy, C3-Cg-alkenyloxy, and benzyloxy, whereby aromatic ring systems in the substitutents can be substituted independently from each other by one to three of the same or different groups selected from halogen, cyano, C^-Cg-alkyl , trifluoromethyl , C 3 ~Cg- cycloalkyl, phenyl, benzyl, hydroxy, Ci-Cg-hydroxyalkyl, C]_- Cg-alkoxy, C^-Cg-alkoxy entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, C^-Cg-alkylthio, carboxy, C 2 -C 7 -carboxyalkyl, C2-C 7 -carboxyalkenyl, C 2 -C 7 - alkoxycarbonyl , benzyloxycarbonyl, nitro, amino, mono-C^-Cg- alkylamino, di- (C^-Cg-alkyl) -amino and, methylene dioxide in the case of two adjacent residues on the aromatic ring, and whereby alkyl-, alkenyl- and cycloalkyl residues in the groups G 1 , G 2 and G 3 can be substituted by one or two of the same or different groups which are selected from hydroxy, carboxy, C 2 -C 7 -alkoxycarbonyl, benzyloxycarbonyl, amino, mono-C^-Cg-alkylamino and di- (Cτ_-Cg-alkyl-amino) . According to a further very preferred embodiment, the invention relates to compounds of Formula (I) , wherein R 1 is selected from hydrogen, fluorine, chlorine, bormine, methyl, ethyl, trifluoromethyl, hydroxy, C 1 -C4-alkoxy, methylthio, ethlythio, caroboxy and phenoxy; R 2 is selected from hydrogen, chlorine and methyl; R 3 is hydrogen; R 4 is selected from hydrogen, Cι-C3-alkyl and hydroxy, k is 0 A is selected from C2~Cg-alkylene, which is optionally substituted once or twice by hydroxy or fluorine; C 2 ~C -alkylene, wherein a methylene unit is isosterically replaced by 0, S or CO, whereby, with the exception of CO, the isosteric substitution cannot be adjacent to the amide group; C2-Cg-alkenylene which is optionally substituted by C]_- C3-alkyl and/or fluorine; C4-Cg-alkadienylene ; D is selected from C2-Cg-alkylene which is optionally substituted by methyl or hydroxy; C 4 ~C -alkenylene, which is optionally substituted by hydroxy; C4-Cg-alkinylene, which is optionally substituted by hydroxy; C 2 ~Cg-alkylene, C4~Cg-alkenylene, C 4 ~Cg-alkinylene wherein a methylene unit is respectively isosterically replaced by 0, NH, NfCHβ), CO or S0 2 or an ethylene group is isosterically replaced by a group NH-CO and/or CO-NH or a propylene group is isosterically replaced by a group NH-CO-0 and/or 0-CO-NH; E is selected from piperazine or hexahydro-1, 4-diazepine (homopiperazine) , wherein the ring can be optionally substituted by one or two methyene groups and/or by an oxo group adjacent to a nitrogen atom; G is selected from hydrogen, C 3 -Cg-cycloalkyl, methoxy- carbonyl, tert-butoxycarbonyl, benzyloxycarbonyl, trifluoroacetyl, diphenylphosphinoyl, or a group —(CH 2 )—(CR 14 R 15 )—R 13 and -C— (CH 2 ) r — (CR 14 R 15 )— R 13 II I S O and — C— (CH 2 )— NR 13 R 15 II r O and — SO 2 — (CH 2 ) r R 13 wherein r has the meaning 0 or 1 s is 0 or 1, R 13 is selected from hydrogen, methyl, benzyl, phenyl, indanyl, indenyl, oxoindanyl, naphthyl, tetra- hydronaphthyl , fluorenyl, oxofluorenyl , anthryl, dihydroanthryl , oxodihydroanthryl , dioxodihydroanthryl , phenanthryl , dihydrophenanthryl , oxydihydrophenanthryl , dibenzocycloheptenyl , dihydrodibenzocycloheptenyl , oxodihydrodibenzocycloheptyl bound directly or over a methylene group, furyl, thienyl, oxazolyl, isooxazoly, thiazolyl, imidazolyl, oxadiazolyl, pyridyl, pyrazinyl, pyrimidinyl, imidazothiazolyl, benzofuryl, benzothienyl, indolyl, indolinyl, oxoindolinyl, dioxoindolinyl, benzoxazolyl, oxobenzoxoazolinyl, benzothiazolyl, oxobenzthiazolinyl, benzimidazolyl, oxobenzimidazolmyl, indazolyl, benzofurazanyl , benzotriazolyl, oxazolo- pyridyl, oxodihydrooxazolopyridyl , thiazolopyridyl, oxodihydrothiazolopyridyl , imidazopyridyl , oxodihydroimidazopyridyl, chromanyl, chromanonyl, benzopyranyl, chromonyl, quinolyl, isoquinolyl, oxodihydroquinolinyl, tetrahydroquinolyl, oxotetrahydroquinolinyl, benzodioxanyl , quinazolinyl , carbazolyl, acridinyl, dihydroacridinyl , oxodihydro- acridinyl , dihydrophenanthridinyl dihydrobenzo isoquinolinyl, phenothiazinyl, dihydrodibenzoxepinyl , benzocycloheptathienyl , dihydrothienobenzothiepinyl , dihydrodibenzothiepinyl , oxodihydrodibenzothiepinyl , dihydrodibenzoazepinyl , oxodihydrodibenzoazepinyl , octahydrodibenzoazepinyl , benzocycloheptapyridyl , dihydropyridobenzodiazepinyl , dihydrodibenzothiazepinyl bound directly or over a methylene group, R 14 is selected from hydrogen, methyl, benzyl, phenyl; R- 1 - 5 is selected from hydrogen, hydroxy, methyl, benzyl, phenyl ; naphthyl, tetrahydronaphthyl , furyl, thienyl, oxazolyl, thiazolyl, imidazolyl, pyridyl, benzofuryl, benzothienyl, indolyl, indolinyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, chromanyl, quinolyl or tetrahydroquinolyl bound directly or over a methylene group; whereby the grouping -NR^R 1 - 5 represents a ring bound over the nitrogen atom of a residue from the series pyrrolidine, piperidine, hexahydroazepine, piperazine, hexahydrodiazepine, morpholine, hexahydroxazepine, thiomorpholine, 7-aza-bicyclo [2, 2.1] heptane, 2,5-diaza- bicyclo [2.2.1] heptane, indoline, isoindoline, (1H)- dihydroquinoline, (1H) -tetrahydroquinoline, (2H) - tetrahydroisoquinoline, (4H) -dihydrobenzoxazine, (4H) - dihydrobenzothiazine, (1H) -tetrahydrobenzo [b] azepine, (1H) -tetrahydrobenzo [d] azepine, (5H) -tetrahydroben- zo [b] oxazepine, (5H) -tetrahydrobenzo [b] thiazepine, (10H) -dihydroacridine, 1, 2, 3 , 4-tetrahydroacridanone, (10H) -dihydrophenanthridine, (1H) -dihydrobenzo- [d, e] isoquinoline, (10H) -phenothiazine, (5H) - dibenzo [b, f] azepine, (5H) -dihydrodibenzo [b, f] azepine, (5H) -dihydrodibenzo [c, e] azepine, (5H) -dihydrodibenzo- diazepine, (IIH) -dihydrodibenzo [b, e] oxazepine (11H)- dihydrodibenzo [b, e] thiazepine, (5H) - dihydrobenzo [b] pyrido [3, 2-f] azepine and (HH)-6- oxodihydrobenzo [e] pyrido [3, 2-b] [1, 4] diazepine, and whereby aromatic ring systems in the substituents can be substituted, independently of each other, by one to three of the same or different groups selected from halogen, cyano, C^-Cg-alkyl, trifluoromethyl , C 3 -C3- cycloalkyl, phenyl, benzyl, hydroxy, Ci-Cg-hydroxyalkyl, Cη_-Cg-alkoxy, C^-Cg-alkoxy which can be entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, Ci-Cg-alkylthio, carboxy, C2-C 7 -carboxyalkyl, C2-C 7 -carbocyalkenyl , C 2 -C 7 -alkoxycarbonyl , benzyloxycarbonyl, nitro, amino, mono-C^-Cg-alkylamino or di- (Cχ-Cg-alkyl) -amino, and in the case of two adjacent residues on the aromatic ring, methylenedioxy, and whereby alkyl, alkenyl and cycloalkyl residues in the group G can be substituted by one or two of the same or different groups which are selected from hydroxy, carboxy, C 2 -C 7 -alkoxycarbonyl, benzyloxycarbonyl , amino, mono-Ci-Cg-alkylamino and ki- (Ci-Cg-alkyl) amino. Furthermore, according to a particularly preferred embodiment, the invention relates to compounds of formula (I) , wherein R 1 is selected from hydrogen, fluorine, methyl, trifluoromethyl ethylthio; R 2 , R 3 and R 4 are each hydrogen; k has the meaning 0 , A is selected from ethylene, propylene or butylene which are each optionally substituted by hydroxy or one or two fluorine atoms; or OCH 2 , SCH 2 ; ethenylene, or 1 , 3-butadienylene; D is selected from C 2 ~Cg-alkylene which is optionally substituted by hydroxy; C 4 ~Cg alkenylene,- C 4 ~C alkinylene; or C 2 ~C alkylene, C 4 ~Cg alkenylene or C 4 ~Cg alkinylene, wherein one or two methylene units is isosterically replaced by O, NH, CO or SO2 ; E is selected from piperazine or hexahydro-1, 4- diazeazepine ; G is selected from phenyl, benzyl, phenethyl, diphenylmethyl , naphthyl, tetrahydronaphtyl, naphthylmethyl , fluorenyl fluorenylmethyl , anthrylmethyl , dihydrodibenzo- cycloheptenyl ; furylmethyl, thienylmethyl, thiazolylmethyl, pyridylmethyl , benzothienylmethyl , quinolylmethyl, phenylthienylmethyl , phenylpyridylmethyl , benzocycloheptapyridinyl , dihydrobenzocyclo- heptapyridinyl , dihydrodibenzooxepinyl , dihydrodibenzothiepinyl, dihydrodibenzoazepinyl , dihdrobenzopyridodiazepinyl ; formyl, acetyl, pivaloyl, phenylacetyl, diphenylacetyl , diphenylpropionyl , naphthylacetyl , benzoyl, naphthoyl, oxofluorenylcarbonyl , oxodihydroanthrylcarbonyl , dioxodihydroanthrylcarbonyl , furoyl, pyridylacetyl, pyridylcarbonyl, chromonylcarbonyl , quinolylcarbonyl , phenylylaminocarbonyl , naphthylaminocarbonyl , tetrahydronaphthylaminocarbonyl , dibenzylaminocarbonyl , benzylphenylaminocarbonyl , diphenylaminocarbonyl , indolinyl-N-carbonyl , isoindolin-N-carbonyl , tetrahydroquinolinyl-N-carbonyl , carbazolyl-N-carbonyl , tetrahydrobenzoazepinyl-N-carbonyl, dihydrodibenzoazepin-N-carbonyl , dihydrobenzopyridoazepinyl-N-carbonyl , oxodihydrobenzopyridoazepinyl-N-carbonyl ; methanesulfonyl, toluenesulfonyl, naphthylsulfonyl, quinolinsulfonyl and diphenylphosphinoyl , wherein aromatic ring systems can be substituted independently of each other by one to three of the same or different groups which are selected from halogen, cyano, C^- Cg-alkyl, trifluoromethyl, C3-Cg-cycloalkyl , phenyl, benzyl, hydroxy, C^Cg-hydroxyalkyl, C j L-Cg-alkoxy, C^-Cg-alkoxy entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, C^-Cg-alkylthio, carboxy, C2-C7- carboxyalkyl , C2-C7~carboxyalkenyl, C2-C7-alkoxycarbonyl , benzyloxycarbonyl, nitro, amino, mono-C^-Cg-alkylamino or di- (Ci-Cg-alkyl) -amino, and in the case of two adjacent residues in the aromatic ring methylenedioxy, and whereby alkyl, alkenyl and cycloalkyl residues in the group G can be substituted by one or two of the same or different groups which are selected from hydroxy, carboxy, C2-C7 -.alkoxycarbonyl, benzyloxycarbonyl, amino, mono-C ] _-C -alkylamino or di- (C^-Cg-alkyl ) -amino . The following end products represent very particular concrete preferred embodiments of the invention: a) N- [4- (4-diphenylmethylpiperazin-l-yl) -3-hydroxybutyl] -3- pyridin-3 -yl-acrylamide ; N- [3- (4-diphenylmethylpiperazin-l-yl) -propoxy] -3-pyridin-3- yl -acrylamide; N- [4- (4-diphenylmethylpiperazin-l-yl) -4-oxo-butyl] -3-pyridin- 3 -yl -acrylamide ; N- [3- (4-diphenylmethylpiperazin-l-sulfonyl) -propyl] -3- pyridin-3 -yl-acrylamide ; N- {2- [2- (4-diphenylmethylpiperazin-l-yl) -ethoxy] -ethyl} -3-py- ridin- 3 -yl-acrylamide ; N- (4- {4- [bis- (4-fluorphenyl) -methyl] -piperazin-1-yl} -but-2- in-yl) -3 -pyridin-3 -yl-acrylamide; N-{4- [4- (4-carboxyphenyl-phenylmethyl) -piperazin-1-yl] - butyl } -3 -pyridin-3 -yl-acrylamide and N- (4- {4- [ (4-aminophenyl) -phenylmethyl] -piperazin-1-yl} - butyl) -3 -pyridin-3 -yl-acrylamide. b) N-{4- [4- (9H-fluoren-9-yl) -piperazin-1-yl] -butyl} -2- (pyridin-3-yloxy) -acetamide; N- {5- [4- (9H-fluoren-9-yl) -piperazin-1-yl] -pentyl} -3-pyridin- 3 -yl -acrylamide ; N- {6- [4- (9H-fluoren-9-yl) -piperazin-1-yl] -hexyl} -3 -pyridin-3 - yl -acrylamide; 3-pyridin-3-yl-N- {4- [4- (1,2,3 , 4-tetrahydronaphthalin-l-yl) - piperazin-1-yl] -butyl} -acrylamide; 3-pyridin-3-yl-N- {4- [4- (5, 6, 7, 8-tetrahydronaphthalin-l-yl) - piperazin-1-yl] -butyl} -acrylamide and N-{4- [4- (naphthalin-1-yl) -piperazin-1-yl] -butyl} -3 -pyridin-3- yl -acrylamide . c) N- [4- (4-biphenyl-2-yl-piperazin-l-yl) -butyl] -3-pyridin-3- yl-propionamide; N- [5- (4-biphenyl-2-yl-piperazin-l-yl) -pentyl] - 3-pyridin-3- yl -acrylamide ; N- [6- (4-biphenyl-2-yl-piperazin-l-yl) -hexyl] -3 -pyridin-3 -yl- acrylamide,- N- [4- (4-biphenyl-2-yl-piperazin-l-ly) -butyl] -2- (pyridin-3- yloxy) -acetamide as well as N- [4- (4-biphenyl-2-yl-piperazin-l-yl) -butyl] -5- (pyridin-3- yl) -penta-2, 4-diensaureamide. d) N-{4- [4- (10, ll-dihydro-5H-dibenzo[a,d] cyclohepten-5-yl) - piperazin-1-yl] -butyl } -3 -pyridin-3 -yl-propionamide ; N-{5- [4- (10, ll-dihydro-5H-dibenzo[a,d] cyclohepten-5-yl) - piper-azin-1-yl] -pentyl} -3 -pyridin-3 -yl-acrylamide; N- {6- [4- (10, ll-dihydro-5H-dibenzo [a,d] cyclohepten-5-yl) - piper-azin-1-yl] -hexyl} -3 -pyridin-3 -yl-acrylamide; N- {4- [4- (10, ll-dihydro-5H-dibenzo [a,d] cyclohepten-5-yl) - piper-azin-1-yl] -butyl} -5- (pyridin-3-yl) -penta-2 , 4- diensaureamide ; N- {4- [4- (6, 11-dihydro-dibenzo [b, e] oxepin-11-yl) -piperazin-1- yl] -butyl-3 -pyridin-3 -yl -propionamide and N- {2- [4- (6, 11-dihydrodibenzo [b, e] thiepin-11-yl) -piperazin-1- yl] -ethyl} -3-pyridin-3-yl-acrylamide . e) N- [4- (4-diphenylacetyl-piperazin-l-yl) -butyl] -3-pyridin-3- yl -acrylamide; N- [4- (4-benzoylpiperazin-l-yl) -butyl] -3-pyridin-3-yl- acrylamide,- N-{4- [4- (2-aminobenzoyl) -piperazin-1-yl] -butyl} -3-pyridin-3- yl-acrylamide ; N-{4- [4- (4-carboxybenzoyl) -piperazin-1-yl] -butyl} -3-pyridin- 3 -yl -acrylamide ; N- {4- [4- (biphenyl-2 -carbonyl) -piperazin-1-yl] -butyl} -3- pyridin-3 -yl-acrylamide ; N- {4- [4- (9-oxo-9H-fluoren-4-carbonyl) -piperazin-1-yl] -butyl} - 3 -pyridin-3 -yl-acrylamide and N-{4- [4- (furan-2 -carbonyl) -piperazin-1-yl] -butyl} -3-pyridin- 3 -yl-acrylamide . f) N-{4- [4- (naphthalin-1-yl-aminocarbonyl) -piperazin-1-yl] - butyl } -3 -pyridin-3 -yl -propionamide ; N- {4- [4- (diphenylaminocarbonyl) -piperazin-1-yl] -butyl} -3- pyridin-3 -yl-acrylamide ; N- {4- [4- (naphthalin-2 -sulfonyl) -piperazin-1-yl] -butyl} -3- pyri-din-3-yl-acrylamide as well as N- [4- (4-diphenylphosphinonyl-piperazin-l-yl) -butyl] -3- pyridin-3 -yl-acrylamide. g) N- [4- (4-biphenyl-2 -yl-piperazin-1-yl) -butyl] -3-pyridin-3- yl -acrylamide ; N-{4- [4- (9H-fluoren-9-yl) -piperazin-1-yl] -butyl} -3-pyridin-3- yl-acrylamide and N- {4- [4- (10 , ll-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) - piper-azin- 1-yl] -butyl} -3 -pyridin-3 -yl-acrylamide. In the following, a series of compounds with the respective specific substituent definitions are listed in Table 1 without any limitation for further illustration of the compounds according to the invention. Table 1 Exemplifying compounds of formula (I) according to the invention Table 1 (continuation) 55 Table 1 (continuation) 55 Table 1 (continuation) 57 Table 1 (continuation) 53 Table 1 (continuation) 59 Table 1 (continuation) 60 Table 1 (continuation) 61 Table 1 (continuation) 62 Tab le 1 (continuation) 63 Table 1 (continuation) Table 1 (continuation) 65 Table 1 (continuation) 66 Table 1 (continuation) 67 Table 1 (continuation) 68 Table l ( continuation) &9 Table 1 ( continuation) 70 Table 1 (continuation) 71 Table 1 (continuation) 72 Table 1 (continuation) 73 Table 1 (continuation) /4 Table 1 (continuation) 75 Table 1 (continuation) 76 Table 1 (continuation) 77 Table 1 (continuation) 78 Table 1 (continuation) 79 Table 1 (continuation) 80 Table 1 (continuation) 81 T a ble 1 (continuation) 82 Table 1 (continuation) 83 T a ble l ( continuation) 84 Table l (continuation) 85 Table 1 (continuation) 86 Table 1 (continuation) 87 Table 1 (continuation) 88 Table 1 (continuation) 89 Table 1 (continuation) 90 Table 1 (continuation) 91 -Table 1 (continuation) 92 Table 1 (continuation] 93 Table 1 (continuation) 94 Further subject-matter of the claims are known analogous methods for the production of the compounds of formula (I) according to the invention. According to method variant (A) , compounds of formula (I) are (a) obtained in the manner by reacting carboxylic acids of formula (II) in which R 1 , R , R 3 , A and k have the meaning given above or their reactive derivatives with compounds of formula (III) H wherein D, E, G and R 4 also have the above described meanings and the meanings given in the claims . Reactive derivatives of compound (II) can be, for example, activated esters, anhydrides, acid halides (especially acid chlorides) or simple low alkyl esters. Suitable activated esters are, for example, p-nitrophenyl ester, 2 , , 6-trichlor- phenyl ester, pentachlorophenyl ester, cyanomethyl ester, esters of N-hydroxysuccinimide, N-hydroxyphthalimides, 1- hydroxybenzotriazole, N-hydroxypiperidine, 2-hydroxypyridine, 2-mercaptopyridine, etc. Anhydrides can be symmetric anhydrides or mixed, as they are obtained, for example, with pivaloyl chloride or with chloroformates . Aromatic (for example chloroformic phenyl ester) , araliphatic (for example chloroformic benzyl ester) or aliphatic chloroformates (for example chloroformic methyl ester, -ethyl ester or -isobutyl ester) can be used for this. Reaction of compounds (II) with compounds (III) can also be carried out in the presence of condensation agents such as dicyclohexylcarbodiimide, l-ethyl-3- (3-dimethylaminopropyl) - carbodiimide hydrochloride, N, N 1 -carbonyldiimidazole, 1- ethoxycarbonyl-2-ethoxy-l, 2-dihydroquinoline, etc. If carbodiimides are used as the condensation agent, reagents such as N-hydroxysuccinimide, N-hydroxyphthalimide, 1- hydroxybenzotriazole, N-hydroxypiperidine, etc. can be advantageously added. Compounds of formula (III) can be used for reaction as free bases as well as in the form of their acid addition salts. For this, the salts of inorganic acids are to be preferred, i.e. hydrochlorides, hydrobromides or sulfates for example. Reaction of compounds (II) or their reactive derivatives with compounds (III) are normally carried out in a suitable, preferably inert solvent. As examples, aromatic hydrocarbons such as benzene, toluene, xylene, halogenated hydrocarbons (for example dichloromethane, chloroform, 1, 2-dichloroethane, trichloroethylene) , ethers (for example diethyl ether, tetrahydrofuran, dioxane, glycol dimethyl ether) , ethyl acetate, acetonitrile or polar aprotic solvents such as, for example, dimethylsulfoxide, dimethylformamide or N-methyl- pyrrolidone are to be named. Pure solvents, as well as mixtures of two or more of them, can be used. The reaction is optionally carried out in the presence of an auxiliary base. Suitable examples for this are alkali metal carbonates (sodium carbonate, potassium carbonate) , alkali metal hydrogen carbonates (sodium hydrogen carbonate, potassium hydrogen carbonate) , or organic bases such as, for example, triethylamine, ethyl diisopropylamine, tributylamine, N-methylmorpholine or pyridine. A suitable excess of compound (III) can also be used as a base. If compounds (III) are used in form of their acid addition salts, then it is appropriate to consider the amount of auxiliary base used as equivalent. The reaction temperatures can - depending on reactivity of the starting materials - vary in a wide range. Generally, the reaction is carried out at temperatures between -40 °C and 180°C, preferably between -10°C and 130°C, especially at the boiling point of the solvent used. The starting compounds and/or intermediates (II) and (III) are known and/or can be produced according to known methods in an analogous manner. Moreover, their production is further described below by means of representative examples. Compounds of formula (I) can also be produced according to the variant pursuant to Method B by reaction of compounds of formula (I) wherein G is hydrogen, whereby the latter which themselves are anti-proliferative active ingredients according to the invention (as follows from the definitions for the general formula) . Thereby, the reaction of compounds according to formula (I) occurs with a compound of formula (IV) , L G (IV) in which G has the meaning given above, with the exception of hydrogen, and L represents a suitable nucleofuge or reactive group . The type of nucleofuge or reactive group L and the conditions of the reaction are dependent of the nature of group G. According to a further variant pursuant to method (BI) compounds of formula (I) , in which G, with the exception of hydrogen, has the meaning of G 1 according to the above definition can also be synthesized by reacting compounds of formula (I) , in which G is hydrogen, with a suitable alkylation agent and/or arylation agent of formula (IV) , wherein G is an alkyl-, alkenyl-, alkinyl-, cycloalkyl-, aryl-, aralkyl-, heteroaryl- or heteroaralkyl residue according to definition and the leaving group L can be a reactive derivative of an alcohol, for example, a halogen atom such as chlorine, bromine or iodine or a sulfonic acid ester, i.e. for example a methanesulfonyloxy group, trifluoromethanesulfonyloxy- , ethanesulfonyloxy- , benzene- sulfonyloxy- , p-toluenesulfonyloxy- , p-bromobenzene- sulfonyloxy- , m-nitrobenzenesulfonyloxy group, etc. A reactive group L can be a terminal epoxide group. The reaction of compounds (I), in which G is a hydrogen, and (IV) is usually conducted in a suitably inert solvent. Such solvents can be for example, aromatic hydrocarbons (benzene, toluene, xylene) , ethers (for example tetrahydrofuran, dioxane, glycol dimethyl ether) , ethyl acetate, acetonitrile, ketones (acetone, ethyl methyl ketone) , polar protic solvents such as alcohols (ethanol, isopropanol, butanol, glycol monomethyl ether) or polar aprotic solvents such as, for example, dimethylsulfoxide, dimethylformamide or N- methylpyrrolidone . Pure solvents as well as mixtures of two or more can also be used. Preferably, the reactions are carried out in the presence of bases, whereby the same bases as named in method (a) above can be used. If chlorides or bromides are used as compound (IV) , the reaction can be accelerated by the addition of alkali metal iodides, for example sodium iodide, potassium iodide. The reaction temperatures can vary between 0°C and 180°C depending on the reactivity of the educts, but preferably lie between 20 °C and 130°C. Finally, according to the variant pursuant to method (B2) compounds of formula (I) , in which G represents an acyl residue, a carbamoyl residue, a sulfonyl residue or a phosphinoyl residue according to the above definition, can also be produced in a manner by reacting compounds of formula (I) , wherein G is hydrogen, with a carboxylic acid, carbamic acid, sulfonic acid and/or phosphinic acid of formula (V) , HO- (V) wherein G is an acyl residue, carbamoyl residue, sulfonyl residue or phosphinoyl residue according to definition, or their derivatives capable of reaction. Preferred derivatives of carboxylic acids and/or sulfonic acids (V) which are capable of reaction are symmetric or unsymmetric carboxylic acid anhydrides and/or sulfonic acid anhydrides or acyl- and/or sulfonyl halides, especially acyl- and/or sulfonyl chlorides. Preferred derivatives of carbamates and/or phosphinic acids which are capable of reaction are the carbamoyl halides and/or phosphinyl halides, especially carbamyl- and/or phosphinyl chlorides. The reaction of the acids (V) and/or their reactive derivatives with compounds (I) , in which G is hydrogen, preferably occurs in the presence of auxiliary bases in solvents and under conditions as they are described in method (A) . Compounds of formula (I) , wherein G represents a carbamoyl residue according to the definition (G2b) with r = 0, i.e. is a group -C-NR 13 R 15 O can also be produced pursuant to the variant according to method (B3) by reacting compounds of formula (I) , in which G is hydrogen, with a carbonyl group transmitter to an intermediate product and subsequently reacting this directly with a primary or secondary amine with the formula (VI) H-NR 13 R 15 (VI) Mp 13_15 wherein R 13 and R 15 and/or the grouping NR ^ have the above meanings without purifying or isolating the intermediate product. Bis-trichloromethyl carbonate ( triphosgene) and carbonyldiimidazole have been proven as particularly reactive carbonyl group transmitters . The reaction of compounds of formula (I), wherein G is hydrogen, with triphosgene and/or carbonyldiimidazole are typically conducted in an absolute, inert solvent in the presence of a tertiary organic a ine as an auxiliary base in such a manner that the solution of compounds (I) and the auxiliary base are slowly poured into a solution of an equivalent amount of carbonyl group transmitter. Thereby, the reaction requires molar ratios of 1 -. 1 for the reaction of compound (I) and carbonyldiimidazol , and, in contrast, a ratio of 1 : 0.35 for the use of triphosgene. After complete reaction of the components to the intermediate product, compound (VI) is added in stochiometric amounts or in excess as a solution or a solid, whereby the reaction is typically completed at elevated temperature. Suitable inert solvents are, for example hydrocarbons such as hexane, heptane, benzene, toluene, xylene, chlorinated hydrocarbons (for example dichloromethane, chloroform, 1,2- dichloroethane, trichloroethylene) , ethers (for example diethyl ether, tetrahydrofuran, dioxane) , esters such as ethyl acetate, butyl acetate, acetonitrile or polar aprodic solvents such as formamide or dimethylformamide . Pure solvents as well as mixtures of various solvents can be used. Sometimes it is of advantage to carry out the first partial reaction at low temperature in a low-viscosity, highly- volatile solvent and to remove the solvent after formation of the intermediate and replace it by a higher boiling solvent . Amines such as for example triethylamine, ethyl diisopropylamine, tributylamine, N-methylmorpholine or pyridine are suitable as auxiliary bases. If compounds (I) or (VI) are used as salts, the amount of the auxiliary base is increased accordingly. The reaction temperatures can lie between -40°C and 50°C for the first partial reaction, preferably 0°C to 30°C, and between 0°C and 150°C for the second partial reaction, preferably 20°C to 120 °C. Finally, according to variant pursuant to method (B4) compounds of formula (I), wherein G represents a carbamoyl residue according to the definition (G2b) with r = 0 and R 15 = hydrogen, i.e. the group represents can also be produced by reacting the compounds of formula (I) in which G is hydrogen, with an isocyanate of formula (VII) in which R 13 has the meaning according to definition Reaction of the compounds of formula (I) , in which G is hydrogen, with the isocyanates of formula (VII) are conducted thereby in an absolute, inert solvent which can be a hydrocarbon such as pentane, hexane, heptane, benzene, toluene, or xylene, chlorinated hydrocarbons (such as dichloromethane, chloroform, 1, 2-dichloroethane, trichloroethylene) , an ether (for example, diethyl ether, tetrahydrofuran, dioxane) , esters such as ethyl acetate, butyl acetate, or polar aprotic solvents such as formamide or dimethylformamide . Mixtures of various solvents can also be used. Thereby, the reaction temperatures can vary in the region from -20°C to 150°C, but preferably lie at 20°C to 100°C. As already mentioned, the compounds of formula (I) , wherein G is hydrogen, are themselves active ingredients according to the invention with tumor growth inhibiting activity. However, independent of their therapeutic applicability, they also represent useful intermediate compounds for the production of a multitude of other compounds according to the invention corresponding to the method variants (BI) to (B4) . In principle, the compounds of the formula (I) , in which G represents hydrogen, can be produced according to method A by reacting a carboxylic acid of formula (II) with amines of formula (III) in which G is hydrogen as described above. However, since the compounds of formula (III) with hydrogen as G represent α, ω-diamines , the formation of product mixtures is always to be expected in their reaction with carboxylic acids (II) or their reactive derivatives making a subsequent separation necessary. In contrast, compounds of formula (I) , in which G is hydrogen, are essentially more advantageously produced from other compounds of formula (I) , in which G is a selectively cleavable group under mild conditions, i.e. corresponds to a nitrogen protective group. In this connection, among the compounds according to formula (I) with tumor growth inhibiting properties, compounds in which G represents a benzyl group, a 4-methoxybenzyl group, a diphenylmethyl group, a triphenylmethyl group, a benzyloxycarbonyl group, a methoxy- and/or ethoxycarbonyl group, a tert-butoxycarbonyl group, an allyloxycarbonyl group or a trifluoroacetyl group are particularly suitable. Thus, compounds of formula (I) with benzyl, diphenylmethyl, triphenylmethyl or benzyloxy-carbonyl groups as G can already be catalytically transformed into compounds of formula (I) with hydrogen as G at room temperature under mild conditions with elementary hydrogen or by transfer hydration. Compounds of formula (I) with a 4-methoxybenzyl group are converted to compounds of formula (I) with hydrogen as G by selective oxidation with ammonium-cer (IV) -nitrate . The cleavage of simple alkoxycarbonyl groups such as the methoxy- or ethoxycarbonyl group as well as the trifluoroacetyl group as G in compounds of formula (I) succeed by alkali hydrolysis under mild conditions without cleaving the A and D linked amide function. This is suitably valid for the cleavage of the triphenylmethyl group and the tert-butoxycarbonyl group in the form of G in compounds of formula (I) which occurs in acidic medium under mild conditions. Finally, compounds of formula (I) with an allyloxycarbonyl group as the meaning for G can be converted into such with hydrogen as the meaning for G in neutral medium with palladium catalys . All these methods are fully familiar to the person skilled in the art, and are furthermore also documented in various monographs, see for example Greene, Wuts : Protective Groups in Organic Synthesis, New York, 1991. The compounds of formula (I) produced according to the methods (A) to (B) can be isolated and purified in a known manner, for example by subjecting the residue after distillation of the solvent to partition, extraction, re- precipitation or re-crystallization or another purification method. For this, column chromatography on a suitable support or preparative middle or high pressure liquid chromatography (HPLC) are preferred for this. The compounds (I) are first normally obtained in form of their free bases or their hydrates or solvates, depending on the type of isolation and purification. Their addition salts with pharmaceutically suitable acids are obtained in a typical manner by converting the base with the desired acid in a suitable solvent. Depending on the number of basic centers of compounds (I) , one or more equivalent acids per mole of base can be bound. Suitable solvents are, for example, chlorinated hydrocarbons such as dichloro ethane or chloroform; ethers such as diethyl ether, dioxane or tetrahydrofuran; acetonitrile; ketones such as acetone or ethyl methyl ketone; esters such as methyl acetate or ethyl acetate or low molecular alcohols such as methanol, ethanol or isopropanol; and water. Pure solvents as well as mixtures of two or three solvents can also be used. The salts can be isolated by crystallization, precipitation or the evaporation of the solvent. Thereby, they optionally accumulate as hydrates or solvates . The bases can be recovered from the salts by alkalization, for example with aqueous ammonia solution, alkali carbonate or diluted sodium hydroxide solution. The following synthetic examples for end products as well as for starting products and/or intermediate products are meant for illustrating the method variants given above and claimed compounds - SYNTHETIC EXAMPLES for the end products of the invention according to formula (I) In the production examples for the end products, the abbreviations stand for the following terms: MP = melting point, RT = room temperature, MPLC = intermediate pressure liquid chromatography THF = tetrahydrofuran, DMF = dimethylformamide, abs . = absolute, CDI = carbonyldiimidazole, EDC = N- (3-dimethylaminopropyl) -N' -ethyl-carbodiimide hydrochloride , HOBT = 1-hydroxybenzotriazole, TEA = triethylamine. " " " H-NMR-Spectrum = proton resonance spectrum, taken at 100 MHz . The chemical shifts are given in ppm against TMS as a standard (δ = 0.0), whereby Ξ = singlet, d = doublet, t = triplet, dt = doublet-triplet , m = multiplet , ar = aromatic, py = pyridine . Example 1 N- [3- (4-diphenylmethylpiperazin-l-yl) -propoxy] -3-pyridin-3- yl-acryla ide (substance 30) 3.8 g (22,9 mmol) of 3- (3-pyridyl) -acrylic acid are suspended in 40 ml absolute dichloromethane and after addition of two drops pyridine, are cooled to ca. 0°C in an ice bath under moisture exclusion. 5 ml (58,5 mmol) of oxalyl chloride are slowly added and the mixture is first stirred for 30 min under ice cooling and then stirred overnight at RT. Subsequently, the solvent and excess oxalyl chloride are distilled off on a rotary evaporator. In order to completely remove the oxalyl chloride, the colorless residue is dried further for two hours under high-vacuum. The acid chloride obtained in this manner is suspended without further purification in 30 ml absolute dichloromethane and cooled to ca. 0°C in an ice bath under moisture exclusion. 7.45 g (22.9 mmol) 3- (4-diphenylmethyl-piperazinyl ) -propyl- hydroxylamine are dissolved in 40 ml absolute dichloromethane and are added dropwise to this suspension. After complete addition, the ice bath is removed and the reaction is stirred for a further two hours at RT. The mixture is subsequently concentrated, taken up in 10% sodium hydroxide solution and extracted three times with acetic acid ethyl ester. The combined organic phases are washed with saturated NaCl solution, dried over sodium sulfate and the solvent is removed under vacuum. The residue is chromatographically purified over silica gel with CHCI 3 /CH 3 OH (99/1 to 85/15) and crystallized twice from acetic ethyl acid ester after evaporation of the solvent: Colorless crystals with a MP . of 115 - 117°C; yield 3.66 g (35%). C 28 H 32 N 4 0 2 (456.6) IR-Spectrum (KBr) : n(NH) 3200 cm "1 n(C=0) 1660 cm "1 n(C=C) 1630 cm "1 1 H-NMR-Spectrum (DMSO-D6) : 1.50 - 1.90 (2H, m, C-CH 2 -C) 2.05 - 2.65 (10H, m, piperazine, N-CH 2 ) 3.86 (2H, t, OCH 2 , J=6.1 Hz) 4.24 (1H, s, Ar 2 CH) 6.54 (1H, d, CH=CHC0, J=16.0 Hz) 7.05 - 7.70 (13H, m, Ar, Py, NH, CH=CHC0) 7.90 - 8.15 (1H, m, Py) 8.50 - 8.70 (1H, m, Py) 8.70 - 8.90 (1H, m, Py) Example 2 N- [4- (4-diphenylphosphinoyl-piperazin-l-yl) -butyl] -3-pyridin- 3 -yl-acrylamide (substance 234) 2.7 g (18 mmol) 3- (3 -pyridyl) -acrylic acid and 3.1 g (19 mmol) CDI are heated under reflux in 100 ml absolute THF under moisture exclusion. After an hour, this is cooled to RT and 7.0 g (19 mmol) 4- (4-diphenyl-phosphinoyl-piperazin-l- yl) -bu-tylamine, dissolved in 30 ml absolute THF, is added dropwise. Following addition, this is further stirred for three hours at RT and left standing overnight . The mixture is poured into 150 ml water and extracted three times with acetic acid ethyl ester by shaking. The combined organic phases are washed with saturated NaCl solution, dried over sodium sulphate and the solution is removed under vacuum. The residue is chromatographically pre-purified over silica gel with CHCI 3 /CH 3 OH (85/15) . After removal of the solvent, the colorless oily residue is further purified by preparative middle pressure chromatography with CH C1 2 /CH 3 0H (93/7) : yield 3.5 g (40%) as amorphous solid material. C 28 H 33 N 4 0 2 P (488.5) 1 H-NMR-Spectrum (CDC1 3 ) 1.40 - 1.80 (4H, m, C-CH 2 -CH 2 -C) 2.20 - 2.60 (6H, m, piperazine, N-CH 2 ) 2.90 - 3.25 (4H, m, piperazine) 3.25 - 3.55 (2H, m, CONHCH 2 ) 6.53 (1H, d, CH=CHCO, J=15.7 Hz) 6.70 - 6.95 (1H, , NH) 7.00 - 8.00 (13H, m, Ar, Py, CH=CHCO) 8.54 (1H, dd, Py, J=1.4Hz, J=4.8Hz) 8.70 (1H, d, Py, J=1.8Hz) Example 3 N- [4- (4-diphenylmethyl-piperazin-1-yl) -3-hydroxy-butyl] -3- pyridin-3 -yl-acrylamide (substance 29) Production analogues to Example 2. Batch size: 2.0 g (13.3 mmol) 3- (3 -pyridyl) -acrylic acid, 2.4 g (14.6 mmol) CDI and 4.5 g (13.3 mmol) 4- (4-diphenyl-methyl - piperazin-1-yl) -3-hydroxy-butylamine . The addition of the amine occurs at -10°C. Subsequently, this is stirred further for an hour at 0°C. In the purification, chromatography first occurs with CHCI 3 /CH 3 OH (95/5) ; subsequently, crystallization occurs once from 20 ml ethanol and twice each from 50 ml acetic acid ethyl ester : Colorless crystals of MP . 168 - 171 ° C ; yield 0 . 4 g ( 6% ) . C 29 H 34 N 4 O 2 ( 470 . 6 ) IR-Spectrum (KBr) n(NH) 3270 cm " n(C=0) 1660, 1565 cm n(C=C) 1615 cm "1 H-NMR-Spectrum (CDCI 3 ) 1.25 - 2.00 (2H, m, C-CH 2 -C) 2.05 - 2.85 (10H, , piperazine, N-CH 2 ) 3.00 - 3.60 (2H, , CH-OH) 3.60 - 4.00 (2H, , CONHCH 2 ) 4.22 (1H, s, Ar 2 CH) 6.44 (1H, d, CH=CHCO, J=15.7 Hz) 6.60 - 8.85 (1H, m, NH) 6.95 - 7.60 (IIH, m, Ar, Py) 7.58 (1H, d, CH=CHCO, J=15.7 Hz) 7.65 - 7.90 (1H, m, Py) 8.45 - 8.65 (1H, m, Py) 8.65 - 8.85 (1H, m, Py) Example 4 N- [4- (4-diphenylmethyl-piperazin-l-yl) -4-oxo-butyl] -3- pyridin-3 -yl-acrylamide (substance 31) Production analogous to Example 1. Batch size: 2.3 g (15.4 mmol) 3- (3 -pyridyl) -acrylic acid, 4 ml (46.8 mmol) oxalyl chloride and 5.2 g (15.4 mmol) 4- (4- diphenyl -methyl -piperazin- 1-yl ) -4-oxo-butylamine . In the purification, chromatography first occurs with CHCI 3 /CH 3 OH (90/10) ; subsequently, crystallization occurs twice from 400 ml acetic acid ethyl ester and 300 ml ethyl methyl ketone: colorless crystals of MP. 179 - 180°C; yield 3.2 g (45%) . C 2 9 H 32 N 4 θ2 ( 468 . 6 ) IR- Spectrum ( Kbr) n(NH) 3240 cm n(C=0) 1665, 1550 cm " n(C=C) 1630 cm "1 H-NMR- Spectrum (CDC1 3 ) : 1.70 - 2.10 (2H, m, C-CH 2 -C) 2.15 - 2.65 (6H, m, piperazine, CO-CH 2 ) 3.20 - 3.80 (6H, m, CONHCH 2/ piperazine) 4.20 (1H, ε, Ar 2 CH) 6.45 (1H, d, CH=CHCO, J=15.7 Hz) 6.75 - 7.00 (1H, m, NH) 7.05 - 7.55 (IIH, m, Ar, Py) 7.58 (1H, d, CH=CHCO, J=15.7 Hz) 7.70 - 7.90 (1H, m, Py) 8.45 - 8.65 (1H, m, Py) 8.65 - 8.85 (1H, m, Py) Example 5 N- [3- (4-diphenylmethyl-piperazin-l-yl-sulfonyl) -propyl] -3- pyridin-3 -yl-acrylamide (substance 32) Production analogous to Example 1. Batch size: 0.5 g (3.3 mmol) 3- (3-pyridyl) -acrylic acid, 2 ml (23.4 mmol) oxalyl chloride and 1.24 g (3.3 mmol) 3- (4- diphenyl -methyl-piperazin-1-yl- sulfonyl ) -propylamine . In the purification, chromatography first occurs CHCI 3 /CH 3 OH (95/5) ; subsequently, crystallization occurs from 75 ml acetic acid ethyl ester: colorless crystals of MP . 167 - 168°C; yield 0.7 g (84%) . C 28 H 32 N 4 O 3 S [504.6) IR-Spectrum ( Br) n(C=0) 1660, 1540 cm "1 • " " H-NMR-Spectrum (CDC1 3 ) 2.00 - 2.35 (2H, m, C-CH 2 -C) 2.35 - 2.65 (4H, m, piperazine) 3.00 (2H, t, S0 2 -CH 2 , J=7.1 Hz) 3.20 - 3.40 (4H, m, piperazine) 3.57 (2H, dt, CONHCH 2 , J=6.4 Hz, J=12.8 Hz) 4.27 (1H, s, Ar 2 CH) 6.10 - 6.35 (1H, m, NH) 6.47 (1H, d, CH=CHCO, J=15.7 Hz) 7.05 - 7.55 (IIH, , Ar, Py) 7.63 (1H, d, CH=CHCO, J=15.7 Hz) 7.70 - 7.95 (1H, m, Py) 8.50 - 8.65 (1H, m, Py) 8.70 - 8.85 (1H, m, Py) Example 6 N-{2- [2- (4-diphenylmethyl-piperazin-l-yl) -ethoxy] -ethyl}-3- pyridin-3 -yl-acrylamide trihydrochloride (substance 35 as trihydrochloride) Production analogous to Example 1. Batch size: 6.0 g (40 mmol) 3- (3-pyridyl) -acrylic acid, 9.4 ml (110 mmol) oxalyl chloride and 12.4 g (36.5 mmol) 2- [2- (4- diphenylmethyl-piperazin-1-yl) -ethoxy] -ethyla ine . The crude product is chromatographically pre-purified over silica gel with CHCI 3 /CH 3 OH (98/2 to 95/5) . After removal of the solvent, the residue is dissolved in isopropanol and mixed with isopropanolic HCl solution. The mixture is rotated in and the HCl salt is cyrstallized from 50 ml methanol/6 drops diisopropyl ether: Colorless crystals of MP . 157 - 159°C; yield 0.6 g (3%) . C 29 H 34 N 4 O 2 • 3HC1 (580.0) IR- Spectrum ( Kbr) n (NH) 3240 cm n ( C=0) 1670, 1550 cm " n (C=C) 1630 cm '1 1 H-NMR-Spectrum (CD 3 OD) 3.40 - 4.00 (16H, m, piperazine, CH 2 -CH 2 -O-CH 2 -CH 2 ) 5.58 (1H, s, Ar 2 CH) 7.14 (1H, d, CH=CHCO, J=15.8 Hz) 7.30 - 7.95 (10H, m, Ar) 7.67 (1H, d, CH=CHCO, J=15.8 Hz) 8.10 - 8.25 (1H, m, Py) 8.80 - 9.00 (2H, , Py) 9.15 - 9.20 (1H, m, Py) Example 7 N-{4- [4- (bis- (4-fluorophenyl) -methyl) -piperazin-1-yl] -but-2- in-yl}-3-pyridin-3-yl-acrylamide»trihydrochloride (substance 47 as trihydrochloride) Production analogous to Example 1. Batch size: 2.5 g (16.9 mmol) 3- (3-pyridyl) -acrylic acid, 2 ml (23 mmol) oxalyl chloride and 6.0 g (16.9 mmol) 4-{4-[bis- (4 -fluorophenyl) -methyl] -piperazin-1-yl} -but-2-inylamine . The crude product is chromatographically pre-purified over silica gel with CHCI 3 /CH 3 OH (95/5) . After removal of the solvent, the residue is dissolved in methanol and mixed with methanolic HCl solution. The drawn off HCl salt is first crystallized from isopropanol and subsequently from ethanol/ diisopropylether : Colorless crystals of MP . 160 - 163 °C; yield 3.5 g (35%) . C 29 H 28 F 2 N 4 0 • 3HC1 (595.9) IR-Spectrum (KBr) n(NH) 3240 cm -1 n(C=0) 1670, 1550 cm n(C=C) 1630 cm "1 X H-NMR-Spectrum (D 2 0) 2.95 - 3.55 (8H, m, piperazine) 3.80 - 4.10 (4H, m, CH 2 -CC-CH 2 ) 5.04 (1H, ε, Ar 2 CH) 6.72 (1H, d, CH=CHCO, J=15.9 Hz) 6.85 - 7.60 (9H, m, Ar, CH=CHCO) 7.80 - 8.00 (1H, m, Py) 8.50 - 8.70 (2H, m, Py) 8.70 - 8.85 (1H, m, Py) Example 8 3-pyridin-3-yl-N-{4- [4- (1, 2 , 3 , 4- tetrahydronaphthalin-1-yl) - piperazin-1-yl] -butyl} -acrylamide (substance 87) Production analogous to Example 2. Batch size: 2.7 g (18 mmol) 3- (3 -pyridyl) -acrylic acid, 3.15 g (19 mmol) CDI and 5.0 g (17.4 mmol) 4- [4-(1,2, 3,4- tetrahydro-naphthalin-1-yl) -piperazin-1-yl] -butylamine. In the purification, chromatography first occurs with CHCI 3 /CH 3 OH (95/5 to 90/10) ; subsequently, crystallization occurs twice each from 40 ml 1-chlorobutane: Colorless crystals of MP . 110 - 114°C; yield 3.7 g (50%). C 26 H 34 4 O (418,6) IR-Spectrum (Kbr) n(NH) 3300 cm "1 n(C=0) 1650, 1530 cm " n(C=C) 1620 cm "1 H-NMR-Spectrum (CDC1 3 ) : 1.40 - 2.10 (8H, m, C-CH 2 -CH 2 -C, cyclohexyl) 2.25 - 3.10 (12H, m, piperazine, N-CH 2 , cyclohexyl) 3.30 - 3.60 (2H, , CONHCH 2 ) 3.70 - 4.00 (1H, m, cyclohexyl) 6.50 (1H, d, CH=CHCO, J=15.7 Hz) 6.90 - 7.45 (5H, m, Ar, Py, NH) 7.62 (1H, d, CH=CHCO, J=15.7 Hz) 7.50 - 7.90 (2H, m, Py, Ar) 8.50 - 8.65 (1H, m, Py) 8.70 - 8.80 (1H, , Py) Example 9 3-pyridin-3-yl-N- [4- (4-{5, 6,7, 8-tetrahydro-naphthalin-l-yl}- piperazin-1-yl) -butyl] -acrylamide (substance 94) 1.6 g (11.1 mmol) 3- (3 -pyridyl) -acrylic acid and 6.2 ml (44.3 mmol) TEA are suspended in 80 ml absolute dichloromethane and cooled to ca. 0°C under moisture exclusion. 2.0 g (12.1 mmol) 81% HOBT and 2.3 g (12.1 mmol) EDC are added and the mixture is stirred for 30 min under ice cooling. 4.0 g (10.1 mmol) 4- [4- (5 , 6 , 7 , 8-tetrahydro-naphthalin-l-yl) -piperazin-1- yl] -butylamine are added and the mixture is stirred without cooling overnight at RT. Subsequently, the batch is washed twice with 25 ml 2M sodium hydroxide solution and 25 ml water. The organic phase is dried over sodium sulfate and the solvent is removed under vacuum. The residue is chromatographically pre-purified over silica gel with CHCI 3 /CH 3 OH (95/5) and crystallized twice from acetonitrile (25 ml and 15 ml) : Colorless crystals of MP . 108-109°C; yield 2.7 g (64%) . C 2 6H3 4 N 4 O (418.6) IR-Spectrum (Kbr) n(NH) 3260 cm " n(C=C) 1620 cm "1 1 H-NMR-Spectrum (CDC1 3 ) 1.40 2.10 (8H, m, C-CH 2 -CH 2 -C, cyclohexyl) 2.25 3.30 (14H, m, piperazine, N-CH 2 , cyclohexyl) 3.30 - 3.70 (2H, m, CONHCH 2 ) 6.51 (1H, d, CH=CHC0, J=15.6 Hz) 6.70 - 7.45 (5H, m, Ar, Py, NH) 7.63 (1H, d, CH=CHCO, J=15.6 Hz) 7.70 - 7.95 (1H, m, Py) 8.45 - 8.65 (1H, m, Py) 8.65 - 8.85 (1H, m, Py) Example 10 N-{4- [ (naphthalin-1-yl) -piperazin-1-yl] -butyl}-3-pyridin-3 - yl-acrylamide (substance 97) Production analogous to Example 1. Batch size: 3.38 g (22.7 mmol) 3- (3 -pyridyl) -acrylic acid, 7.85 g (61.8 mmol) oxalyl chloride and 8.55 g (20.6 mmol) 4- [ (naphtha-lin-1-yl) -piperazin-1-yl] -butylamine. In the recovery, 40 ml 10% sodium hydroxide solution is added to the reaction solution. The aqueous phase is extracted with dichloromethane. The combined organic phases are washed with 15 ml water, dried over sodium sulfate and the solvent is removed under vacuum. The residue is chromatographically purified over silica gel with CHCI 3 /CH 3 OH (98/2 to 96/4) . After removal of the solvent, this is crystallized three times each with 40 ml acetic acid ethyl ester under addition of 5 drops diisopropylether respectively: solid with MP . 124- 125°C; yield 1.5 g (18%). C 26 H 30 N O (414.6) IR-Spectrum (KBr) : n(NH) 3280 cm "1 n(C=0) 1650, 1545 cm "1 n(C=C) 1620 cm "1 1 H-NMR-Spectrum (CDC1 3 ; 1.45 - 1.95 (4H, , C-CH 2 -CH 2 -C) 2.30 - 3.40 (10H, m, piperazine, N-CH 2 ) 3.30 - 3.60 (2H, m, CONHCH 2 ) 6.50 (1H, d, CH=CHCO, J=15.7 Hz) 6.55 - 6.85 (1H, m, NH) 6.95 - 7.95 (8H, m, Ar, Py) 7.63 (1H, d, CH=CHCO, J=15.7 Hz) 8.05 - 8.35 (1H, m, Py) 8.50 - 8.70 (1H, m, Py) 8.70 - 8.85 (1H, , Py) Example 11 N-{2- [4- (6, 11-dihydrodibenzo [b, e] hiepin-11-yl) -piperazin-1- yl] -ethyl}-3-pyridin-3-yl-acrylamide (substance 138) 5.0 g (14.1 mmol) N- [2- (piperazin-1-yl) -ethyl] -3-pyridin-3- yl-acrylamidetrihydrochloride (substance 317 as trihydrochloride) and 5.8 ml (42.3 mmol) TEA are suspended in 65 ml absolute dichloromethane. 4.7 g (15.5 mmol) 11- methaneεulfonyloxy- 6, 11-dihydrodibenzo [b, e] thiepine dissolved in 60 ml absolute dichloromethane is added dropwise under moisture exclusion. The mixture is stirred overnight at RT. Subsequently, the batch is washed three times each with 50 ml water. The organic phase is dried over sodium sulfate and the solvent is removed under vacuum. The residue is chromatographically purified over εilica gel with CHC1 3 / CH 3 OH (95/5) . Subsequently, a further purification occurs by means of MPLC with CHC1 3 /CH 3 0H (95/5): yield 4.3 g (44%) as an amorphic solid. 28 H 30 N 4 OS (470,6) IR-Spectrum (Kbr) n(NH) 3270 cm " n(C=0) 1655, 1535 cm n(C=C) 1620 cm "1 H-NMR- Spectrum ( CDC1 3 ) 2 . 00 - 2 . 90 ( 10H , m, Piperazine , Piperazin- CH ) 3 . 20 - 3 . 70 ( 3H, m, CONHCH 2 , SCH 2 ) 4 . 10 ( 1H , s , Ar 2 CH) 5.90 - 6.50 (2H, m, NH, SCH 2 ) 6.49 (1H, d, CH=CHCO, J=15.7 Hz) 6.90 - 7.50 (9H, m, Ar, Py) 7.62 (1H, d, CH=CHCO, J=15.7 Hz) 7.75 - 7.95 (1H, m, Py) 8.50 - 8.70 (1H, m, Py) 8.70 - 8.90 (1H, m, Py) Example 12 N- [4- (4-biphenyl-2-yl-piperazin-l-yl) -butyl] -3 -pyridin-3 -yl- acrylamide (substance 68) Production analogous to Example 1. Batch size: 5.8 g (39.1 mmol) 3- (3 -pyridyl) -acrylic acid, 9.1 ml (106 mmol) oxalyl chloride and 5.0 g (16.1 mmol) 4- (4- biphenyl-2 -yl-piperazin-1-yl ) -butylamine . In the recovery, 60 ml 10% sodium hydroxide solution is added to the reaction solution. The aqueous phase is extracted twice each with 15 ml dichloromethane. The combined organic phases are washed twice each with 15 ml water, dried over sodium sulfate and the solvent is removed under vacuum. The residue is chromatographically purified over silica gel with CHCI 3 /CH 3 OH/NH 4 OH (85/15/2) . After removal of the solvent, this is crystallized twice with 1-chlorobutane : solid with MP. 115°C; yield 3.3 g (46%). C 28 H 32 N 4 O (440.6) IR-Spectrum (Kbr) : n(NH) 3280 cm " n(C=0) 1650, 1545 cm " n(C=C) 1620 cm "1 H-NMR-Spectrum (CDC1 3 ) 1.35 - 1.85 (4H, m, C-CH 2 -CH 2 -C) 2.10 - 2.55 (6H, m, piperazine, N-CH 2 ) 2.75 - 3.00 (4H, m, piperazine) 3.20 - 3.50 (2H, m, C0NHCH 2 ) 6.44 (1H, d, CH=CHCO, J=15.6 Hz) 6.45 - 6.70 (1H, m, NH) 6.95 - 7.85 (12H, m, Ar, CH=CHCO, Py) 8.45 - 8.65 (1H, m, Py) 8.65 - 8.80 (1H, m, Py) Example 13 N-{4- [4- (9H-fluoroen-9-yl) -piperazin-1-yl] -butyl}-3-pyridin- 3 -yl-acrylamide (substance 101) Production analogous to Example 1. Batch size: 19.2 g (129 mmol) 3- (3-pyridyl) -acrylic acid, 15.1 ml (176 mmol) oxalyl chloride and 37.6 g (117 mmol) 4- (9-fluoroenyl-piperazin-1-yl) -butylamine . In the recovery, 150 ml 10% sodium hydroxide solution is added to the reaction εolution. The organic phase is washed three times each with 60 ml water, dried over sodium sulfate and the solvent is removed under vacuum. The residue is chromatographically purified over silica gel with CHCI 3 /CH 3 OH (90/10) . After removal of the solvent, this is crystallized with 1700 ml acetic acid ethyl ester: solid with MP. 145- 147°C; yield 39.0 g (73%). C 29 H 32 4 O (452.6) IR-Spectrum (Kbr) n(NH) 3300 cm " n(C=C) 1620 cm "1 H-NMR-Spectrum (CDC1 3 ) 1.35 - 1.80 (4H, m, C-CH 2 -CH 2 -C) 2.10 - 2.80 (10H, m, piperazine, N-CH 2 ) 3.20 - 3.50 (2H, , CONHCH 2 ) 4.81 (1H, s, Ar 2 CH) 6.34 (1H, d, CH=CHCO, J=15.7 Hz) 6.75 - 7.05 (1H, , NH) 7.00 - 7.80 (IIH, m, Ar, CH=CHCO, Py) 8.40 - 8.60 (1H, m, Py) 8.60 - 8.70 (1H, m, Py) Example 14 N-{4- [4- (10,ll-dihydro-5H-dibenzo [a,d] cyclohep en-5-yl) - piperazin-1-yl] -butyl} -3 -pyridin-3 -yl-acrylamide (substance 119) Production analogous to Example 1. Batch size: 4.16 g (27.9 mmol) 3- (3-pyridyl) -acrylic acid, 6.5 ml (76.2 mmol) oxalyl chloride and 12.2 g (25.4 mmol) 4- [4- (10 , ll-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) - piperazin-1-yl] -butylamine. In the recovery, 50 ml 10% sodium hydroxide solution is added to the reaction solution. The aqueous phase is extracted with dichloromethane. The combined organic phases are washed with 50 ml water, dried over sodium sulfate and the solvent is removed under vacuum. The residue is chromatographcially pre-purified over silica gel with CHCI 3 /CH 3 OH (98/2 to 90/10) . After removal of the solvent, this is crystallized four-fold each with 50 ml acetic acid ethyl ester: Colorless solid with MP. 119-120°C; yield 4.9 g (40%) . C 31 H 36 N 4 O (480.7) IR-Spectrum (Kbr) n(NH) 3280 cm n(C=0) 1670, 1540 cm n(C=C) 1625 cm "1 H-NMR-Spectrum (CDC1 3 ) : 1.40 - 1.80 (4H, m, C-(CH 2 ) 2 -C) 2.10 - 2.55 (10H, m, piperazine, N- CH 2 ) 2.55 - 3.00 (2H, m, Ar-CH 2 -CH 2 -Ar) 3.20 - 3.50 (2H, m, C0NHCH 2 ) 4.75 - 4.20 (3H, m, Ar 2 CH, Ar-CH 2 -CH 2 -Ar) 6.50 (1H, d, CH=CHC0, J=15.7 Hz) 6.90 - 7.40 (10H, m, Ar, Py, NH) 7.61 (1H, d, CH=CHCO, J=15.7 Hz) 7.70 - 7.85 (1H, m, Py) 8.50 - 8.65 (1H, m, Py) 8.70 - 8.80 (1H, m, Py) Example 15 N- [2- (4-diphenylacetyl-piperazin-l-yl) -ethyl] -3 -pyridin-3 -yl- acrylamide (substance 158) 8.0 g (22.6 mmol) N- [2- (piperazin-1-yl) -ethyl] -3-pyridin-3- yl-acrylic amide trihydrochloride (substance 317 as a trihydrochloride) and 13 ml (92.7 mmol) TEA are present in 100 ml absolute dichloromethane and cooled to ca. 0°C under moisture exclusion. 6.3 g (24.9 mmol) diphenylacetyl chloride (90%) are dissolved in 70 ml absolute dichloromethane and added dropwise. The mixture is stirred overnight at RT without further cooling. Subsequently, 200 ml dichloromethane are added and the batch is washed three times each with 100 ml water. The organic phase is dried over sodium sulfate and the solvent is removed under vacuum. The residue is cryεtallized twice from 40 ml and 30 ml acetonitrile . Beige coloured crystals of MP. 174°C. yield 4.6 g (44%) . C 28 H 3 oN 4 θ 2 (454.6) IR-Spectrum (Kbr) : n(NH) 3320 cm "1 n(C=0) 1675, 1550 cm "1 n(C=C) 1610 cm '1 1 H-NMR-Spectrum (CDC1 3 ) 2.10 - 2.60 (6H, m, piperazine, N- CH 2 ) 3.30 - 3.85 (6H, m, piperazine, C0NHCH. 2 ) 5.20 (1H, ε, Ar 2 CH) 6.20 - 6.40 (1H, m, NH) 6.46 (1H, d, CH=CHCO, J=15.7 Hz) 7.10 - 7.40 (IIH, m, Ar, Py) 7.61 (1H, d, CH=CHCO, J=15.7 Hz) 7.70 - 7.90 (1H, m, Py) 8.50 - 8.65 (1H, m, Py) 8.70 - 8.80 (1H, m, Py) Example 16 N-{2- [4- (10, 11-dihydro-dibenzo [b, f] azepin-5 -yl-carbonyl) - piperazin-1-yl] -ethyl} -3 -pyridin-3-yl-propionamide (substance 215) Production analogous to Example 15. Batch size: 8.0 g (21.5 mmol) N- [2- (piperazin-1-yl) -ethyl] -3- pyridin-3 -yl -propionamide -trihydrochloride, 12.3 ml (88.1 mmol) TEA and 6.1 g (23.6 mmol) 10, 11-dihydro- dibenzo [b, f] azepin-5-carbonyl chloride in 170 ml absolute dichloromethane . In the purification, this is first chromatographically pre- purified over silica gel with CHCI 3 /CH 3 OH (100/0 to 90/10) and, after removal of the solvent, crystallized from 10 ml acetonitrile. Colorless crystals of MP. 146 - 147°C. yield 0.7 g (6%) . C 2 9 H3 3 N 5 0 2 ( 483 . 6 ) IR- Spectrum ( KBr) : n(NH) 3330 cm n(C=0) 1660, 1535 cm n(C=C) 1630 cm "1 1 H-NMR-Spectrum (CDC1 3 ) 2.10 - 2.60 (8H, m, piperazine, C0-CH 2; N-CH 2 ) 2.96 (2H, t, Py-CH 2 , J=7.4 Hz) 3.10 - 3.45 (10H, m, CONHCH 2 . piperazine, Ar-CH 2 -CH - Ar) 5.80 - 6.00 (1H, m, NH) 7.00 - 7.60 (10H, m, Ar, Py) 8.35 - 8.55 (2H, m, Py) Example 17 N-{2- [4- (naphthalin-2-yl-sulfonyl) -piperazin-1-yl] -ethyl}-3 pyridin-3 -yl-acrylamide (substance 227) Production analogous to Example 15. Batch size: 8.0 g (22.6 mmol) N- [2- (piperazin-1-yl) -ethyl] -3 - pyridin-3-yl-acrylamide • trihydrochloride (substance 317 as a trihydrochloride), 13 ml (92.7 mmol) TEA and 5.6 g (24.9 mmol) naphthalin-2-εulfonic acid chloride in 180 ml absolute dichloromethane . For purification, this is crystallized twice from 150 ml and 100 ml acetonitrile . Beige coloured crystals of MP. 183 - 184°C. yield 4.0 g (39%). C 24 H 26 N 4 0 3 S (450.6) IR-Spectrum (Kbr) n(NH) 3250 cm n(C=0) 1665, 1555 cm n(C=C) 1625 cm "1 H-NMR-Spectrum (CDC1 3 ; 2.35 - 2.80 (6H, m, piperazine, N-CH 2 ) 3.00 - 3.35 (4H, m, piperazine) 3.44 (2H, dd, CONHCH 2 , J=5.5 Hz, J=11.2 Hz) 5.90 - 6.15 (1H, m, NH) 6.35 (1H, d, CH=CHCO, J=15.6 Hz) 7.15 - 8.15 (9H, , Ar, CH=CHC0, Py) 8.35 (1H, bs , Ar) 8.45 - 8.60 (1H, m, Py) 8.60 - 8.75 (1H, m, Py) Example 18 N-{2- [4- (tert-butoxycarbonyl) -piperazin-1-yl] -ethyl] -3- pyridin-3 -yl-acrylamide (substance 374) Production analogous to Example 1. Batch size: 36.1 g (242 mmol) 3- (3 -pyridyl) -acrylic acid, 23.1 ml (264 mmol) oxalyl chloride, 50 g (15.4 mmol) 2- [4- ( tert-but-oxycarbonyl) -piperazin-1-yl] -ethylamine and 30.4 ml (220 mmol) TEA in 400 ml absolute dichloromethane. In the purification, thiε is crystallized twice from 100 ml acetic acid ethyl ester and 150 ml 1-chlorbutane : Colorless crystals of MP . 92 - 93°C; yield 38.4 g (48%). C 19 H 28 N 4 O 3 (360.5) IR-Spectrum (Kbr) n(NH) 3320 cm n(C=0) 1670, 1530 cm " n(C=C) 1620 cm "1 1 H-NMR-Spectrum (CDC1 3 ) 1.47 (9H, s, tert. Butyl ) 2.30 - 2.80 (6H, m, piperazine, N-CH 2 ) 3.30 - 3.70 (6H, m, piperazine CONHCH 2 ) 6.30 - 6.55 (1H, , NH) 6.52 (1H, d, CH=CHCO, J=15.7 Hz) 7.20 - 7.40 (1H, m, Py) 7.63 (1H, d, CH=CHC0, J=15.7 Hz) 7.70 - 7.90 (1H, m, Py) 8.45 - 8.65 (1H, m, Py) 8.65 - 8.85 (1H, m, Py) Example 19 N- [2- (piperazin-1-yl) -ethyl] -3-pyridin-3-yl-acrylamide«tri- hydrochloride (substance 317 as a trihydrochloride) 38 g ( 105 mmol) N- {2- [4- (tert-butoxycarbonyl) -piperazin-1 yl] -ethyl] -3-pyridin-3-yl-acrylamide (substance 374) are dissolved in 380 ml methanol and 42 ml concentrated hydrochloric are added. The mixture is stirred for four hours under reflux. After cooling of the solution, the solvent is removed under vacuum. The residue is crystallized from 185 ml methanol. Colorless crystals of MP. 216 -226 °C (under decomposition) . yield 34.8 g (93%) . C i4 H 20 N 4 O-3HCl (369,7) IR-Spectrum (Kbr) : n(NH) 3150 cm "1 n(C=0) 1670, 1540 cm " n(C=C) 1610 cm "1 ■ ""H-NMR-Spectrum (D 2 0) 3.20 - 3.75 (12H, m, piperazine, N-CH 2 -CH 2 ) 6.74 (1H, d, CH=CHC0, J=15.9 Hz) 7.44 (1H, d, CH=CHCO, J=15.9 Hz) 7.80 - 8.00 (1H, m, Py) 8.50 - 8.70 (2H, m, Py) 8.80 - 8.90 (1H, , Py) In the following Table 2, further synthesized end products according to formula (I) are listed: Table 2 : synthesized compounds of formula (I) 1 PE = Petroleum ether EE = Ethyl acetate MEK = Methyl ethyl ketone iPrOH = Isopropanol iPr 2 0 = Diisopropyl ether Me04 = Methanol EtOH = Ethanol MeCN = Acetonitrile BuCI = 1-Chlorobutane 2 Purified by column chromatography 3 as a Trihydrochloridee 4 as a Tetrahydrochloride 5 as a Trioxalate 6 as a Sulfate Production of the Starting Substances Example A 4- (4-diphenylphosphinoyl-piperazin-l-yl) -butylamine a) N-diphenylphosphinoyl -piperazine : 20 g (84.5 mmol) diphenylphosphinate chloride dissolved in 30 ml DMF are added drop ise to a solution of 21.8 g (253 mmol) piperazine in DMF. After four hours, the solution is concentrated under vacuum, taken up in chloroform and extracted by shaking with 10% hydroxide solution. The organic phase is dried over sodium sulfate and solvent is removed under vacuum. The residue is chromatographically purified over silica gel with CHC1 3 /CH 3 0H/TEA (90/10/0 to 90/10/6) : yield 12 g (49%) . b) 2- [4- (4-diphenylphosphinoyl) -butyl] -isoindolin-1, 3-dione: 12 g (41.9 mmol) N-diphenylphosphinoyl-piperazine, 11.8 g (42 mmol) N- (4 -bromobutyl) -phthalimide, 5.8 g (42 mmol) potassium carbonate and 1.4 g (8 mmol) potassium iodide are heated in ethyl methyl ketone for 6 hours under reflux. After cooling, the reaction mixture is concentrated under vacuum. The residue is taken up in acetic acid ethyl ester and extracted by shaking with water. The organic phase is dried over sodium sulfate and the solvent is removed under vacuum: yield 20 g (100%) . c) 4- (4-diphenylphosphinoyl-piperazin-l-yl) -butylamine: 20 g (40 mmol) 2- [4- (4-diphenylphosphinoyl) -butyl] - isoindolin-1, 3-dione and 4 ml (80 mmol) hydrazine hydrate are heated in 400 ml ethanol for three hours under reflux. The cooling solution is concentrated under vacuum and the residue is taken up in acetic acid ethyl ester. The suspension is filtered and the residue is washed with toluene. The filtrate and washing fluid are concentrated under vacuum until dry. Subsequently, the residue is taken up in chloroform and shaken with 10% sodium sulfate. The organic phase is dried over sodium sulfate and the solvent is removed under vacuum. The accumulated crude product is further processed without further purification: yield 13.3 g (95%) . Example B 4- (4-diphenylmethyl-piperazin-l-yl) -3 -hydroxy-butylamine a) 2- (but-3-enyl) -isoindolin-1, 3-dione: 50 g (370 mmol) 4-bromo-l-butene and 68.5 g (370 mmol) phthalimide potassium salt are suspended in 800 ml ethyl methyl ketone and heated under reflux for 14 hours . After cooling, the mixture is filtrated and the filtrate is concentrated under vacuum. The residue is taken up in acetic acid ethyl ester and washed with water. The organic phase is dried over sodium sulfate and the solvent is removed under vacuum: yield 50 g (67%) . b) 2- (3 , 4-epoxybutyl) -isoindolin-1, 3-dione: 70 g (350 mmol) 2- (but-3-enyl) -isoindolin-1, 3-dione are dissolved in dichloromethane. The solution is cooled to ca. 0°C and a suspension of 120.8 g (350 mmol) 50% 3-chloro- peroxy-benzoic acid in dichloromethane is added under cooling. The mixture is left standing without further cooling at room temperature for two days. After addition of 250 ml saturated NaHC0 3 solution the organic phase is separated and washed three times each with 200 ml saturated NaHC0 3 solution and once with water. The organic phase is dried over sodium sulfate and the solvent is removed under vacuum: yield 80 g. c) 2- [4- (4-diphenylmethyl-piperazin-l-yl) -3-hydroxy-butyl] - isoindolin- 1 , 3 -dione : 5 g (-25 mmol) 2- (3 , 4-epoxybutyl) -isoindolin-1, 3-dione, 7.5 g (30 mmol) benzhydrylpiperazine and 3.5 g (25 mmol) potassium carbonate are stirred in DMF for 6 hours 80°C. After cooling, the reaction mixture is filtered and concentrated under vacuum. The residue is taken up in 300 ml acetic acid ethyl ester and washed three times each with 20 ml water. The organic phase is dried over sodium sulfate and the solvent is removed under vacuum. The residue is chromatographically purified over silica gel with CHC1 3 /CH 3 0H (98/2) : yield 5.3 g (95%) . d) 4- (4-diphenylmethyl-piperazin-l-yl) -3 -hydroxy-butylamine : 15 g (30 mmol) 2- [4- (4-diphenylmethyl-piperazin-l-yl) -3-hy- droxy-butyl] -isoindolin-1, 3-dione and 3.9 ml (60 mmol) hydrazine -hydrate (80%) are heated under reflux in 100 ml ethanol for three hours . The cooled solution is concentrated under vacuum and the residue is taken up in acetic acid ethyl ester. The suspension is filtrated and the residue is distributed between acetic acid ethyl ester and 10% sodium hydroxide solution. The combined organic phases are dried over sodium sulfate and concentrated under vacuum until dry. The resin is further processed without further purification: yield 4.8 g (47%) . Example C 1- (4-aminobutyryl) -4-diphenylmethyl-piperazine a) 1- (4 -chlorobutyryl) -4-diphenylmethyl-piperazine: 25 g (99 mmol) benzhydrylpiperazine and 15.2 ml (109 mmol) TEA are present in 200 ml absolute THF and cooled to ca. 0°C under moisture exclusion. 14 g (99 mmol) 4-chlorobutyric chloride are dissolved in 40 ml absolute THF and added dropwise. The mixture is stirred an additional three hours at RT and subsequently filtered. The filtrate is concentrated under vacuum, the residue is taken up in acetic acid ethyl ester and washed with saturated NaCl solution. The organic phase is dried over sodium sulfate and concentrated under vacuum until dry. The resin is further processed without further purification: yield 35.1 g (99%) . b) 1- (4-aminobutyryl) -4 -diphenylmethyl -piperazine : 8.9 g (24.9 mmol) 1- (4-chlorobutyryl) -4-diphenylmethylpiper- azine, 4.8 g (73.8 mmol) sodium azide, 1 g potassium iodide and 1 g molecular sieve 4A are stirred in 70 ml DMF for five hours at 70°C. After cooling, the reaction mixture is filtered and the filtrate is concentrated under vacuum. The accumulated crude product is dissolved in methanol and mixed with a spatula tip of palladium-carbon (10%) . The mixture is stirred for two days at RT under hydrogen atmosphere. The mixture is filtered from the catalyst and the solvent is removed under vacuum. The residue is chromatographically purified over silica gel with CHC1 3 /CH 3 0H/TEA (90/10/5) : yield 5.2 g (62%) as a colorless amorphous solid. Example D 3- (4-diphenylmethyl-piperazin-l-yl-sulfonyl) -propylamine a) 1-diphenylmethyl -4- (3 -chloropropanesulfonyl) -piperazine: 39.2 g (155 mmol) benzhydrylpiperazine and 19.7 ml (141 mmol) TEA are present in 100 ml absolute dichloromethane and cooled to ca. 0°C under moisture exclusion. 25 g (141 mmol) 3- chloropropanesulfonyl chloride are dissolved in 70 ml absolute dichloromethane and added dropwise . The mixture is stirred for two hours under cooling and subsequently mixed with chloroform and washed with saturated NaCl solution. The organic phase is dried over sodium sulfate and concentrated under vacuum until dry. The solid is further processed without further purification: yield 59.2 g. b) 2- [3- (4 -diphenylmethyl -piperazin-1-yl-sulfonyl) -propyl] - isoindolin-1, 3-dione : The reaction of the halogenide to phthalimide occurs analogously to Example B)a) . Batch size: 15 g (38 mmol) l-diphenylmethyl-4- (3- chloropropane sulfonyl) -piperazine and 7.2 g (39 mmol) phthalimide -potassium salt in DMF at 80°C. The purification occurs by chromatography on silica gel with petroleum ether/acetic acid ethyl ester (4/1) . Yield 14 g (71%) . c) 3- (4-diphenylmethyl-piperazin-l-yl-εulfonyl) -propylamine: The reaction of the phthalimide to the amine occurs analogously to Example B) d) . Batch size: 14g (27.8 mmol) 2- [3- (4 -diphenylmethyl -piperazin- 1-yl-sulfonyl) -propyl] -isoindolin-1, 3-dione and 2.8 ml (55.6 mmol) hydrazine • hydrate . The resulting resin is further processed without further purification: Yield 1.5 g (15%). Example E 2- [2- (4-diphenylmethyl-piperazin-l-yl) -ethoxy] -ethylamine a) 2- [2- (4-diphenylmethyl-piperazin-1-yl) -ethoxy] -ethanol : 71.7 g (284 mmol) benzhydrylpiperazine, 45 g (361 mmol) 2- (2- chloroethoxy) -ethanol, 43.2 g (312 mmol) potassium carbonate and 9.4 g (57 mmol) potassium iodide are stirred in 400 ml absolute DMF for 8 hours at 75 °C. After cooling, the solution is concentrated under vacuum. The residue is distributed between acetic acid ethyl ester and water. The aqueous phase is extracted twice with acetic acid ethyl ester and the combined organic phases are washed three times with saturated sodium chloride solution. The organic phase is dried over sodium sulfate and the solvent is removed under vacuum. The residue is chromatographically purified over silica gel with CHC1 3 /CH 3 0H (90/10) : Yield 104g. b) 2- {2- [2- (4 -diphenylmethyl-piperazin-1-yl) -ethoxy] -ethyl} - isoindolin-1, 3-dione: 40 g (-118 mmol) 2- [2- (4-diphenylmethyl-piperazin-l-yl) - ethoxy] -ethanol, 31.1 g (119 mmol) triphenylphosphine and 17.3 g (118 mmol) phthalimide are suspended in 200 ml THF and 24.2 ml (119 mmol) are azodicarbonic acid diethyl ester are added dropwise under protective atmosphere and light cooling (to ca. 15°C) . The mixture is stirred without further cooling for three hours and subsequently, the solvent is removed under vacuum. The residue is taken up in IN HCl and washed twice each with 50 ml acetic acid ethyl ester respectively. The aqueous phase is neutralized with ca. 50 g sodium hydrogen carbonate and extracted four times each with 125 ml chloroform. The combined chloroform phases are dried over sodium sulfate and the solvent is removed under vacuum. The residue is chromatographically purified over silica gel with CHC1 3 /CH 3 0H (99/1 to 90/10) : Yield 11 g (19%) . c)2- [2- (4-diphenylmethyl-piperazin-l-yl) -ethoxy] -ethylamine: The reaction of the phthalimide to the amine occurs analoge&sly to Example B)d) . Batch size: 27g (55.6 mmol) 2- {2- [2- (4-diphenylmethyl- piperazinyl) -ethoxy] -ethyl} -isoindol-1, 3-dione and 5.4 ml (110 mmol) hydrazine -hydrate. The purification occurs by chromatography on silica gel with CHC1 3 /CH 3 0H/TEA (9/1/0 to 9/1/1): Yield 12.4 g (66%). Example F 4 - {4 - [bis - (4 - fluorophenyl) -methyl] -piperazin-l-yl} -but-2 - in- ylamine a) 2 -propinyl - isoindolin- l , 3 -dione : 32.3 g (271 mmol) 3-bromopropine are dissolved in 150 ml DMF and 50.3 g (271 mmol) phthalimide potassium salt are added under ice cooling. The suspension is warmed at 70 °C for eight hours . The mixture is concentrated under a vacuum and the residue is distributed between acetic acid ethyl ester and water. The organic phase is dried over sodium sulfate and the solvent is removed under vacuum. The residue is crystallized from acetic acid ethyl ester: Yield 36.4 g (72%) colorless crystals. b) 2- (4- {4- [bis- (4 -fluorophenyl) -methyl] -piperazin-l-yl} -but- 2-inyl) -isoindolin-1 , 3-dione: 15 g (81 mmol) 2-propinyl-isoindolin-l, 3-dione, 15 g (52 mmol) [bis- (4-fluorophenyl) -methyl] -piperazine, 2.5 g (81 mmol) paraformaldehyde and 0,2 g copper sulfate are stirred for three hours in 200 ml dioxane at 100°C. The cool solution is concentrated under vacuum and the residue is distributed between acetic acid ethyl ester and saturated NaCl solution. The organic phase is dried over sodium sulfate and concentrated under vacuum until dry. The residue is chromatographically purified over silica gel with acetic acid ethyl ester/petroleum ether (l/l) : Yield 23.4 g (93%) yellow amorphous solid. c) 4- {4- [bis- (4-fluorophenyl) -methyl] -piperazin-l-yl} -but-2- inylamine : The reaction of the phthalimide to the amine occurs analogously to Example 21)d): 23.3 g (48 mmol) 2- (4- {4- [bis- (4 -fluorophenyl) -methyl] -piperazin-l-yl} -but-2-inyl) - isoindolin-1, 3-dione and 4.7 ml (96 mmol) hydrazine«hydrate . The purification occurs by chromatography on silica gel with CHC1 3 /CH 3 0H (90/10 to 85/15): Yield 9.8 g (58%). Example G 4- [4- (1,2, 3 , 4-tetrahydronaphthalin-l-yl) -piperazin-l-yl] -butylamine a) 2-{4-[4-(l,2,3, 4-tetrahydronaphthalin-l-yl) -piperazin-l- yl] -butyl} -isoindolin-1, 3-dione • dihydrochloride : 30 g (138,6 mmol) 1- (1, 2 , 3 , 4-tetrahydronaphthyl) -1- piperazine, 40.3 g (140 mmol) N- (4 -bromobutyl) -phthalimide and 27.6 g (200 mmol) potassium carbonate are stirred in 150 ml DMF for three hours at RT. The mixture is concentrated under a vacuum and the residue is distributed between 200 ml acetic acid ethyl ester and 150 ml water. The aqueous phase is extracted 50 ml acetic acid ethyl ester and the combined organic phases are washed four times with water. The organic phase is dried over sodium sulfate and concentrated under vacuum until dry. The residue is dissolved in 400 ml methanol and mixed with 70 ml 6.6M isopropanolic hydrochloric acid. The salt precipitated in the cold is drawn off and dried. Colorless crystals of MP .175-180°C: Yield 53.2 g (78%) . b) 4- [4- (1,2,3, 4-tetrahydronaphthalin-l-yl) -piperazin-l-yl] - butylamine : The reaction of the phthalimide to the amine occurs analogously to Example B) d) . Batch size: 52 g (106 mmol) 2- {4- [4- (1, 2 , 3 , 4- tetrahydronaphthalin-1-yl) -piperazin-l-yl] -butyl} -isoindolin- 1, 3 -dione- dihydrochloride and 14.6 ml (300 mmol) hydrazine- hydrate in 500 ml ethanol. The accumulated crude product is further processed without further purification: Yield 27.4 g (89%). Example H 4- [4- (5,6,7, 8- tetrahydro-naphthalin-1-yl) -piperazin-l-yl] - butylamine*trihydrochloride a) 2-{4-[4-(5,6,7, 8-tetrahydro-naphthalin-l-yl) -piperazin-l- yl] -butyl} -isoindolin-1, 3-dione: The reaction of the piperazine with the phthalimide occurs analogously to Example 26a. Batch size: 24 g (110.9 mmol) 1- (5 , 6 , 7 , 8 , -tetrahydronaphtha- lin-l-yl) -piperazine, 32.6 g (115.4 mmol) N- (4-bromobutyl) - phthalimide and 30.6 g (221.8 mmol) potassium carbonate in 240 ml DMF. The purification occurs by chromatography over silica gel with CHC1 3 /CH 3 0H (100/0 to 98/2): Yield 41.6 g (89%) . b) 4- [4- (5,6,7, 8-tetrahydronaphthalin-l-yl) -piperazin-l-yl] - butylamine • Trihydrochloride : The reaction of the phthalimide to the amine occurs analogously to Example 21d. Batch size: 41.5 g (99.4 mmol) 2- {4- [4- (5 , 6 , 7 , 8-tetrahy- dronaphthalin-l-yl) -piperazin-l-yl] -butyl} -isoindol-in-1, 3- dione and 9.5 ml (198.8 mmol) hydrazine -hydrate in 400 ml ethanol . The purification occurs by a chromatography over silica gel with CHCl 3 /CH 3 OH/NH 4 OH (90/10/0 to 90/9/1) . After removing the solvent the residue is dissolved in 300 ml isopropanol and mixed with 47 ml 6M isopropanolic hydrochloric acid. The salts precipitating in the cold is filtered off and dried: Yield 23.5 g (59%) . Example I 4- [4- (naphthalin-1-yl) -piperazin-l-yl) ] -butylamine a) 2- [4- (naphthalin-1-yl-piperazin-l-yl) -butyl] -iεoindolin- 1, 3-dione : The reaction of the piperazine with the phthalimide occurs analogously to Example G)a) . Batch size: 21 g (100 mmol) 1- (1-naphthyl) -piperazine [Production according to Glennon et al . , J. Med. Chem. 29, 2375 (1986)], 28.3 g (100 mmol) N- (4-bromobutyl) -phthalimide and 20.8 g (150 mmol) potassium carbonate in 250 ml DMF. The accumulated crude product is further processed without further purification: Yield 30 g (68%) . b) 4- [4- (naphthalin-1-yl) -piperazin-l-yl) ] -butylamine: The reaction of phthalimide to the amine occurs analogously to Example B)d) . Batch size: 30 g (68 mmol) 2- [4- (naphthalin-1-yl-piper-azin- 1-yl) -butyl] -isoindolin-1, 3-dione and 6.9g (137 mmol) hydrazine -hydrate in ethanol. The accumulated crude product is further processed without further purification: Yield 14.6 g (75%). Example J 11-methanesulfonyloxy- 6, 11-dihydrodibenzo [b, e] - thiepine a) 6. ll-dihydro-dibenzo [b, e] thiepin-11-ol : 48 g (212 mmol) 6.1-dihydro-dibenzo [b, e] thiepin-11-one are dissolved in 480 ml absolute methanol and cooled to ca. - 10°C. 19.2 g (507 mmol) sodium borohydride is added portion wise to this solution. The mixture is stirred for three hours at RT without further cooling. After the careful addition of 30 ml water, the suspension is concentrated under vacuum. The residue is taken up in 500 ml dichloromethane and washed twice each with 150 ml water. The organic phase is dried over sodium sulfate and the solvent is removed under vacuum. The residue is crystallized from 180 ml toluene. Colorless crystals of MP . 108°C: Yield 41.2 g (85%) . b) 11-methanesulfonyloxy- 6, 11-dihydrodibenzo [b, e] -thiepine: 3.5 g (15.5 mmol) 6 , ll-dihydro-dibenzo [b, e] thiepin-11-ole and 2.4 ml (17 mmol) TEA are dissolved in 50 ml absolute dichloromethane. The mixture is cooled to ca. 5°C and a solution of 1.3 ml (16.3 mmol) methanesulfonyl chloride in 10 ml absolute dichloromethane is added dropwise. The mixture is additionally stirred for two at RT and directly employed in Example 11. Example K 2- (4- tert-butoxycarbonyl-piperazin-1-yl) -ethylamine a) 2- {2- [4- (tert-butoxycarbonyl) -piperazin-l-yl] -ethyl} - isoindolin-1, 3-dione : 44.7 g (240 mmol) N- (tert-butoxycarbonyl) -piperazine, 60.9 g (240 mmol) N- (2 -bromoethyl) -phthalimide, 49.8 g (360 mmol) potassium carbonate and 49.5 g (330 mmol) sodium iodide are heated in 1000 ml ethyl methyl ketone for five hours under reflux. After cooling the reaction mixture and concentrated under vacuum. The residue is taken up in 700 ml chloroform and extracted twice by shaking each with 50 ml water. The organic phase is dried over sodium sulfate and the solvent is distilled off. The residue is crystallized from 110 ml methanol. Colorless crystals of MP . 136 - 138°C: Yield 47.6 g (55%) . b) 2- [4- (tert-butoxycarbonyl) -piperazin-l-yl] -ethylamine: The reaction of the phthalimide to the amine occurs analogously to Example B)d) . Batch size: 42.2 g (120 mmol) 2- {2- [4- ( tert-butoxycarbonyl) - piperazin-l-yl] -ethyl} -isoindolin-1, 3-dione and 11.6 ml (240 mmol) hydrazine -hydrate in 450 ml ethanol. The accumulated crude product is further processed without further purification: Yield 24.8 g (90%) . Example L 4- (4-biphenyl-2-yl-piperazin-l-yl) -butylamine a) 2- [4- (4-biphenyl-2-yl-piperazin-l-yl) -butyl] -isoindolin- 1, 3-dione: The reaction of piperazine with the phthalimide occurs analogously to Example G) a) . Batch size: 15.3 g (64.2 mmol) 1- (o-biphenylyl) -piperazine, 18.5 g (64.2 mmol) N- (4-bromobutyl) -phthalimide and 13.3 g (96 mmol) potassium carbonate in 270 ml ethyl methyl ketone. The purification occurs by chromatography over silica gel with CHC1 3 /CH 3 0H (98/2) : Yield 29 g (99%) . b) 4- (4-biphenyl-2-yl-piperazin-l-yl) -butylamine : The reaction of the phthalimide to the amine occurs analogously to Example B)d) . Batch size: 20.8 g (47.3 mmol) 2- [4- (4-biphenyl-2-yl-piper- azin-1-yl) -butyl] -isoindolin-1, 3-dione and 4.6 ml (94.6 mmol) hydrazine -hydrate in 185 ml ethanol. The accumulated crude product is further processed without further purification: Yield 11.6 g (79%) . Example M 4- [4- (9H-fluoroen-9-yl) -piperazin-l-yl] -butylamine a) 2- {4- [4- (9H-fluoroen-9-yl) -piperazin-l-yl] -butyl}-iso- indol-in-1, 3-dione: The reaction of the piperazine with the phthalimide occurs analogously to Example 26a. Batch size: 25 g (77.3 mmol) 1- (9-fluoroenyl) -piperazine • dihydrochloride, 22.9 g (81 mmol) N- (4-bromobutyl) -phthalimide and 34 g (246 mmol) potassium carbonate in 80 ml DMF. The purification occurs by chromatography over silica gel with CHC1 3 /CH 3 0H (99/1 to 90/10) : Yield 30 g (86%) . b) 4- [4- (9H-fluoroen-9-yl) -piperazin-l-yl] -butylamine: The reaction to the phthalimide to the amine occurs analogously to Example 2Id. Batch size: 33 g (76.4 mmol) 2- {4- [4- (9H-fluoroen-9-yl) - piper-azin-1-yl] -butyl} -isoindolin-1, 3-dione and 7.4 ml (153 mmol) hydrazine -hydrate in ethanol. The accumulated crude product is further processed without further purification: Yield 11.5 g (46%). Example N 4- [4- (10, ll-dihydro-5H-dibenzo [a,d] cyclohe ten-5-yl) -1-piper- azin-1-yl] -butylamine a) 1- (10 , ll-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -piperazine : 48 g (210 mmol) 5-chloro-10 , ll-dihydro-5H- dibenzo [a, d] dicyclo-heptene are dissolved in 500 ml dioxane and after addition of 45 g (522 mmol) piperazine, the mixture is heated under reflux for 7 hours with stirring. After cooling, this is concentrated under vacuum and the residue is distributed between 500 ml chloroform and 300 ml water. The aqueous phase is additionally washed three times each with 200 ml chloroform. The combined organic phases are dried over sodium sulphate and the solvent is removed under vacuum. The residue is chromatographically purified over silica gel with CHC1 3 / CH 3 OH (98/2 to 90/10): Yield 34.5 g (58%). b) 2-{4-[4-(10, ll-dihydro-5H-dibenzo[a,d] cyclohepten-5-yl) - piperazin-l-yl] -butyl} -isoindolin-1, 3-dione : The reaction of the piperazine with the phthalimide occurs analogously to Example G)a) . Batch size: 34.5 g (124 mmol) 1- (10 , ll-dihydro-5H-dibenzo- [a, d] cyclohepten-5-yl) -piperazine, 35 g (124 mmol) N- (4- bromobutyl) -phthalimide and 3.7 g (24.8 mmol) sodium iodide in 80 ml DMF. The purification occurs by chromatography over silica gel with CHC1 3 /CH 3 0H (98/2): Yield 55.3 g (93%). c) 4- [4- (10, ll-dihydro-5H-dibenzo [a,d] cyclohepten-5-yl) -1- piperazin-1-yl] -butylamine: The reaction of the phthalimide to the amine occurs analogously to Example B)d) . Batch size: 30 g (62.5 mmol) 2- {4- [4- (10 , ll-dihydro-5H-di- benzo [a, d] cyclohepten-5-yl) -piperazin-l-yl] -butyl} - isoindolin-1, 3-dione and 6.2 ml (125 mmol) hydrazine»hydrate in 250 ml ethanol. The accumulated crude product is further processed without further purification: Yield 12.8 g (58%). The active ingredients according to the invention can be processed to the desired medicaments in the form of their acid addition salts, hydrates or solvates individually or in combination with each other, optionally under addition of other active ingredients. In the case of the combination of active ingredients according to the invention with other medicinals, these can also optionally be separately present next to each other in the medicine packaging, for example as tablets next to vials, depending on the requirements. Further subject-matter of the invention is a method for the treatment of the human or animal body in which a compound or compound mixture according to formula (I) , wherein the substituents have the above described meanings, is administered for treatment of tumors and/or as a cytostatic agent, cancerostatic agent or as an immunosuppressing agent, optionally in combination with further cytostatic or immunosuppressive active ingredients or other active ingredients suitable for the named indications. Furthermore, the invention relates to a compound or compound mixture according to formula (I) for use in a therapeutic method in which the therapeutic use is carried out in connection with one or more medical indications with tumors or for immunosuppression, optimally in combination with further pharmaceuticals suitable for the named indications. The use of one or more compounds according to formula (I) , for the production of medicaments for the treatment of the human or animal body, especially in connection with one or more medical indications in the treatment of tumors or for immunosuppression, optimally in combination with further pharmaceuticals suitable in these indications or the use of compounds according to formula (I) in a corresponding diagnosis method also represent an embodiment according to the invention, whereby the compounds for the designated medical indications are included that are excluded from claims 1 and 2 in view of the definition of group Gl . The medical indications according to the invention of the compounds excluded from the protective scope of the compound claims are new. The respective suitable tumor indications are illustrated in the last section of the description in the discussion of the pharmacological test results. A method for the production of medicaments with an amount of one or more compounds according to formula (I) which are suitable for the processing of these active ingredients together with respective suitable pharmaceutically acceptable carriers and adjuvants for finished medicinal forms equally belongs to the scope of protection according to the invention. Depending on the medical indication being considered, the respective suitable medicinal form is selected for the suitable therapeutic application, whereby especially 0.001 or 0.01 to 2 mg and/or 0.1, 1, 2, 5, 10, 20, 25, 30, 50, 100, 200, 300, 500, 600, 800, 1000, 2000, 3000, 4000 or 5000 mg of active ingredient according to the claims 1 to 7, 9 and 10 are applied as a dosage and/or dose unit for single administration . The invention also relates to the use of the compounds according to formula (I) for treatment in the above indications, as well as a diagnostic agent. The production methods of the respective suitable medicaments as well as a series of examples of medicinal forms are described in the following for better understanding of the invention. Therapeutic Administration Forms The production of medicaments with an amount of one or more compounds according to the invention and/or their use in the application according to the invention occurs in the customary manner by means of common pharmaceutical technology methods. For this, the active ingredients as such or in the form of their salts are processed together with suitable, pharmaceutically acceptable adjuvants and carriers to medicinal forms suitable for the various indications and types of application. Thereby, the medicaments can be produced in such a manner that the respective desired release rate is obtained, for example a quick flooding and/or a sustained or depot effect. Preparations for parenteral use, to which injections and infusions belong, are among the most important systemically employed medicaments for tumor treatment as well as for other indications . Preferably, injections are administered for the treatment of tumors. These are prepared either in the form of vials or also as so-called ready-to-use injection preparations, for example as ready-to-use syringes or single use syringes in addition to perforation bottles for multiple withdrawals. Administration of the injection preparations can occur in the form of subcutaneous (s.c), intramuscular (i.m.), intravenous (i.v.) or intracutaneous (i.e.) application. The respective suitable injection forms can especially be produced as solutions, crystal suspensions, nanoparticular or colloid-disperse systems, such as for example, hydrosols. The injectable formulations can also be produced as concentrates which can be adjusted with aqueous isotonic dilution agents to the desired active ingredient dosage. Furthermore, they can also be produced as powders, such as for example lyophilisates, which are then preferably dissolved or dispersed immediately before application with suitable diluents. The infusions can also be formulated in the form of isotonic solutions, fat emulsions, liposome formulations, microemulsions and liquids based on mixed micells, for example, based on phospholipids . As with injection preparations, infusion formulations can also be prepared in the form of concentrates to dilute. The injectable formulations can also be applied in the form of continuous infusions as in stationary as well as in outpatient therapy, for example in the form of mini-pumps. Albumin, plasma expanders, surface active compounds, organic solvents, pH influencing compounds, complex forming compounds or polymeric compounds can be added to the parenteral medicinal forms, especially as substances for influencing the adsorption of the active ingredients to protein or polymers or also with the aim of decreasing the adsorption of the active ingredient to materials such as injection instruments or packaging materials, for example plastic or glass. The active ingredients can be bound to nanoparticles in the preparations for parenteral use, for example on finely dispersed particles based on poly (meth) acrylateε, polyacetates, polyglycolates, polyamino acids or polyether urethanes . The parenteral formulations can also be constructively modified as depot preparations, for example on the multiple unit principle, where the active ingredients are incorporated in a most finely distributed and/or dispersed, suspended form or as crystal suspensions, or on the single unit principle, where the active ingredient is enclosed in a medicinal form, for example, a tablet or a seed which is subsequently implanted. Often, these implantations or depot medicaments in single unit and multiple unit medicinal forms consist of so-called biodegradable polymers, such as for example, polyether urethanes of lactic and glycolic acid, polyether urethanes, polyamino acids, poly (meth) acrylates or polysaccharides . Sterilized water, pH value influencing substances, such as for example organic and inorganic acids or bases as well as their salts, buffer substances for setting the pH value, agents for isotonicity, such as for example sodium chloride, monosodium carbonate, glucose and fructose, tensides and/or surface active substances and emulsifiers, such as for example, partial fatty acid esters of polyoxyethylene sorbitan (Tween®) or for example fatty acid esters of polyoxethylene (Cremophor®) , fatty oils such as for example peanut oil, soybean oil and castor oil, synthetic fatty acid esters, such as for example ethyl oleate, isopropyl myristate and neutral oil (Miglyol®) as well as polymer adjuvants such as for example gelatine, dextran, polyvinylpyrrolidone, organic solvent additives which increase solubility, such as for example propylene glycol, ethanol, N,N-dimethylacetamide, propylene glycol or complex forming compounds such as for example citrates and urea, preservatives, such as for example hydroxypropyl benzoate and hydroxymethyl benzoate, benzyl alcohol, anti-oxidants, such as for example sodium sulphite and stabilizers, such as for example EDTA, are suitable as adjuvants and carriers in the production of preparations for parenteral use. In suspensions, addition of thickening agents to prevent the settling of the active ingredients from tensides and peptizers, to secure the ability of the sediment to be shaken, or complex formers, such as EDTA, ensues. This can also be achieved with the various polymeric agent complexes, for example with polyethylene glycols, polystyrol, carboxymethylcellulose, Pluronics® or polyethylene glycol sorbitan fatty acid esters. The active ingredient can also be incorporated in liquid formulations in the form of inclusion compounds, for example with cyclodextrins . As further adjuvants, dispersion agents are also suitable. For production of lyophilisates, builders are also used, such as for example mannite, dextran, saccharose, human albumin, lactose, PVP or gelatine varieties. As long as the active ingredients are not incorporated in the liquid medicinal formulations in the form of a base, they are used in the form of their acid addition salts, hydrates or solvates in the preparations for parenteral use. A further systemic application form of importance is peroral administration as tablets, hard or soft gelatine capsules, coated tablets, powders, pellets, microcapsules, oblong compressives , granules, chewable tablets, lozenges, gums or sachets. These solid peroral administration forms can also be prepared as sustained action and/or depot systems . Among these are medicaments with an amount of one or more micronized active ingredients, diffusions and erosion forms based on matrices, for example by using fats, wax-like and/or polymeric compounds, or so-called reservoir systems. As a retarding agent and/or agent for controlled release, film or matrix forming substances, such as for example ethylcellulose, hydroxypropylmethylcellulose, poly (meth) acrylate derivatives (for example Eudragit®) , hydroxypropylmethylcellulose phthalate are suitable in organic solutions as well as in the form of aqueous dispersions. In this connection, so-called bio-adhesive preparations are also to be named in which the increased retention time in the body is achieved by intensive contact with the mucus membranes of the body. An example of a bio- adhesive polymer is the group of Carbomers®. For sublingual application, compressives, such as for example non-disintegrating tablets in oblong form of a suitable size with a slow release of active ingredient, are especially suitable. For purposes of a targeted release of active ingredients in the various sections of the gastrointestinal tract, mixtures of pellets which release at the various places are employable, for example mixtures of gastric fluid soluble and small intestine soluble and/or gastric fluid resistant and large intestine soluble pellets. The same goal of releasing at various sections of the gastrointestinal tract can also be conceived by suitably produced laminated tablets with a core, whereby the coating of the agent is quickly released in gastric fluid and the core of the agent is slowly released in the small intestine milieu. The goal of controlled release at various sections of the gastrointestinal tract can also be attained by multilayer tablets. The pellet mixtures with differentially released agent can be filled into hard gelatine capsules. Anti-stick and lubricant and separating agents, dispersion agents such as flame dispersed silicone dioxide, disintegrates, such as various starch types, PVC, cellulose esters as granulating or retarding agents, such as for example wax-like and/or polymeric compounds on the basis of Eudragit®, cellulose or Cremophor® are used as a further adjuvants for the production of compressives, such as for example tablets or hard and soft gelatine capsules as well as coated tablets and granulates. Anti-oxidants, sweetening agents, such as for example saccharose, xylite or mannite, masking flavors, aromatics, preservatives, colorants, buffer substances, direct tableting agents, such as for example microcrystalline cellulose, starch and starch hydrolysates (for example Celutab®) , lactose, polyethylene glycols, polyvinylpyrrolidone and dicalciu phosphate, lubricants, fillers, such as lactose or starch, binding agents in the form of lactose, starch varieties, such as for example wheat or corn and/or rice starch, cellulose derivatives, for example methylcellulose, hydroxypropylcellulose or silica, talcum powder, stearates, such as for example magnesium stearate, aluminium stearate, calcium stearate, talc, siliconized talc, stearic acid, acetyl alcohol or hydrated fats, etc. are also used. In this connection, oral therapeutic systems constructed especially on osmotic principles, such as for example GIT (gastrointestinal therapeutic system) or OROS (oral osmotic system) , are also to be mentioned. Effervescent tablets or tabsolute both of which represent immediately drinkable instant medicinal forms which are quickly dissolved or suspended in water are among the perorally administrable compressives. Among the perorally administrable forms are also solutions, for example drops, juices and suspensions, which can be produced according to the above given method, and can still contain preservatives for increasing stability and optionally aromatics for reasons of easier intake, and colorants for better differentiation as well as antioxidants and/or vitamins and sweeteners such as sugar or artificial sweetening agents. This is also true for inspissated juices which are formulated with water before ingestion. Ion exchange resins in combination with one or more active ingredients are also to be mentioned for the production of liquid injestable forms. A special release form consists in the preparation of so- called floating medicinal forms, for example based on tablets or pellets which develop gas after contact with body fluids and therefore float on the surface of the gastric fluid. Furthermore, so-called electronically controlled release systems can also be formulated by which active ingredient release can be selectively adjusted to individual needs. A further group of systemic administration and also optionally topically effective medicinal forms are represented by rectally applicable medicaments. Among these are suppositories and enema formulations. The enema formulations can be prepared based on tablets with aqueous solvents for producing this administration form. Rectal capsules can also be made available based on gelatine or other carriers . Hardened fat, such as for example Witepsol®, Massa Estarinum®, Novata®, coconut fat, glycerol-gelatine masses, glycerol-soap-gels and polyethylene glycols are suitable as suppository bases. For long-term application with a systematic active ingredient release up to several weeks, pressed implants are suitable which are preferably formulated on the basis of so-called biodegradable polymers . As a further important group of systemically active medicaments, transdermal systems are also to be emphasized which distinguish themselves, as with the above-mentioned rectal forms, by circumventing the liver circulation system and/or liver metabolism. These plasters can be especially prepared as transdermal systems which are capable of releasing the active ingredient in a controlled manner over longer or shorter time periods based on different layers and/or mixtures of suitable adjuvants and carriers. Aside from suitable adjuvants and carriers such as solvents and polymeric components, for example based on Eudragit®, membrane infiltration increasing substances and/or permeation promoters, such as for example oleic acid, Azone®, adipinic acid derivatives, ethanol, urea, propylglycol are suitable in the production of transdermal systems of this type for the purpose of improved and/or accelerated penetration. As topically, locally or regionally administration medicaments, the following are suitable as special formulations: vaginally or genitally applicable emulsions, creams, foam tablets, depot implants, ovular or transurethral administration instillation solutions. For opthalmological application, highly sterile eye ointments, solutions and/or drops or creams and emulsions are suitable. In the same manner, corresponding otological drops, ointments or creams can be designated for application to the ear. For both of the above-mentioned applications, the administration of semi-solid formulations, such as for example gels based on Carbopols® or other polymer compounds such as for example polyvinylpyrolidone and cellulose derivatives is also possible . For customary application to the skin or also to the mucus membrane, normal emulsions, gels, ointments, creams or mixed phase and/or amphiphilic emulsion systems (oil/water- water/oil mixed phase) as well as liposomes and transfersomes can be named. Sodium algenate as a gel builder for production of a suitable foundation or cellulose derivatives, such as for example guar or xanthene gum, inorganic gel builders, such as for example aluminium hydroxides or bentonites (so- called thixotropic gel builder) , polyacrylic acid derivatives, such as for example Carbopol®, polyvinylpyrolidone, microcrystalline cellulose or carboxymethylcellulose are suitable as adjuvants and/or carriers. Furthermore, amphiphilic low and high molecular weight compounds as well as phospholipids are suitable . The gels can be present either as hydrogels based on water or as hydrophobic organogels, for example based on mixtures of low and high molecular paraffin hydrocarbons and Vaseline. Anionic, cationic or neutral tensides can be employed as emulsifiers, for example alkalized soaps, methyl soaps, amine soaps, sulfonated compounds, cationic soaps, high fatty alcohols, partial fatty acid esters of sorbitan and polyoxyethylene sorbitan, for example lanette types, wool wax, lanolin, or other synthetic products for the production of oil/water and/or water/oil emulsions. Hydrophilic organogels can be formulated, for example, on the basis of high molecular polyethylene glycols. These gel-like forms are washable. Vaseline, natural or synthetic waxes, fatty acids, fatty alcohols, fatty acid esters, for example as mono-, di-, or triglycerides, paraffin oil or vegetable oils, hardened castor oil or coconut oil, pig fat, synthetic fats, for example based on acrylic, caprinic, lauric and stearic acid, such as for example Softisan® or triglyceride mixtures such as Miglyol® are employed as lipids in the form of fat and/or oil and/or wax-like components for the production of ointments, creams or emulsions. Osmotically effective acids and bases, such as for example hydrochloric acid, citric acid, sodium hydroxide solution, potassium hydroxide solution, monosodium carbonate, further buffer systems, such as for example citrate, phosphate, tries-buffer or triethanolamine are used for adjusting the pH value . Preservatives, for example such as methyl- or propyl benzoate (parabenes) or sorbic acid can be added for increasing stability. Pastes, powders or solutions are to be mentioned as further topically applicable forms. Pastes often contain lipophilic and hydrophilic auxiliary agents with very high amounts of fatty matter as a consistency-giving base. Powders or topically applicable powders can contain for example starch varieties such as wheat or rice starch, flame dispersed silicon dioxide or silica, which also serve as diluents, for increasing flowability as well as lubricity as well as for preventing agglomerates . Nose drops or nose sprays serve as nasal application forms. In this connection, nebulizers or nose creams or ointments can come to use . Furthermore, nose spray or dry powder formulations as well as controlled dosage aerosols are also suitable for systemic administration of the active ingredients . These pressure and/or controlled dosage aerosols and dry powder formulations can be inhaled and/or insufflated. Administration forms of this type also certainly have importance for direct, regional application in the lung or bronchi and larynx. Thereby, the dry powder compositions can be formulated for example as active ingredient-soft pellets, as an active ingredient-pellet mixture with suitable carriers, such as for example lactose and/or glucose. For inhalation or insufflation, common applicators are suitable which are suitable for the treatment of the nose, mouth and/or pharynx. The active ingredients can also be applied by means of an ultrasonic nebulizing device. As a propellant gas for aerosol spray formulations and/or controlled dosage aerosols, tetrafluoroethane or HFC 134a and /or heptafluoropropane or HFC 227 are suitable, wherein non- fluorinated hydrocarbons or other propellants which are gaseous at normal pressure and room temperature, such as for example propane, butane or dimethyl ether can be preferred. Instead of controlled dosage aerosols, propellant-free, manual pump systems can also be used. The propellant gas aerosols can also suitably contain surface active adjuvants, such as for example isopropyl myristate, polyoxyethylene sorbitan fatty acid ester, sorbitan trioleate, lecithins or soya lecithin. For regional application in situ, solutions for instillation, for example for transurethral administration in bladder tumors or genital tumors, or for profusion in liver tumors or other organ carcinomas are suitable. The respective suitable medicinal forms can be produced in accordance with the prescription and procedures based on pharmaceutical-physical fundamentals as they are described for example in the following handbooks and are included in the present inventive subject-matter with respect to the production of the respective suitable medicaments: Physical Pharmacy (A.N. Martin, J. Swarbrick, A. Cammarata) , 2nd Ed., Philadelphia Pennsylvania, (1970), German version: Physikalische Pharmazie, (1987) , 3rd edition, Stuttgart; R. Voigt, M. Bornschein, Lehrbuch der pharmazeutischen Technologie, Verlag Chemie, Weinheim, (1984) , 5th edition; P.H. List, Arzneimformenlehre, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, (1985) , 4th edition; H. Sucker, P. Fuchs, P. Speiser, Pharmazeutische Technologie, Georg Thieme Verlag, Stuttgart - New York, (1991) , 2nd edition,- A.T. Florence, D. Attwood, Physicochemical Principles of Pharmacy, The Maximilian Press Ltd., Hong Kong, (1981); L.A. Trissel, Handbook on Injectable Drugs, American Society of Hospital Pharmacists, (1994) , 8th edition,- Y.W. Chien, Transdermal Controlled Systemic Medications, Marcel Dekker Inc., New York - Basel, (1987); K.E. Avis, L. Lachmann, H.A. Liebermann, Pharmaceutical Dosage Forms: Parenteral Medications, volume 2, Marcel Dekker Inc., New York - Basel, (1986); B. . Mϋller, Controlled Drug Delivery, Paperback APV, volume 17, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, (1987) ,- H. Asch, D. acetic , P.C. Schmidt, Technologie von Salben, Suspensionen and Emulsionen, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, (1984) ; H.A. Liebermann, L. Lachman, J.B. Schwartz, Pharmaceutical Desage forms: Tablets, Volume 1, Marcel Dekker Inc., New York, 2nd Edition (1989) ; D. Chulin, M. Deleuil, Y. Pourcelot, Powder Technology and Pharmaceutical Processes, in J.C. Williams, T. Allen, Handbook of Powder Technology, Elsevier Amsterdam - London - New York - Tokyo, (1994) ; J.T. Carstensen, Pharmaceutical Principles of Solid Dosage Forms, Technomic Publishing Co., Inc., Lancaster - Basel, (1993) . PRODUCTION EXAMPLES 1. Injection therapeutics a) Parenteral Solution active ingredient used according to the invention 5.000 g acid sodium phosphate 5.000 g sodium tartrate 12.000 g benzyl alcohol 7.500 g water for injection purposes to 1000.000 ml The solution is produced according to the customary method, sterilized and filled into 10 ml vials. One vial contains 50 mg of the compound according to the invention. b) Parenteral Solution active ingredient used according to the invention 1.000 g hydrochloric acid, dilute 5.000 g sodium chloride 6.000 g water for injection purposes to 1000.000 ml The solution is produced according to a customary method by stirring; the medicinal form is adjusted to a suitable pH value by acid addition and subsequently filled into 100 ml vials and sterilized. A vial contains 100 mg of the compound according to the invention. c) Parenteral Dispersion active ingredient used according to the invention 10.000 g soya lecithin 20.000 g saturated triglycerides 100.000 g sodium hydroxide 7.650 g water for injection purposes to 1000.000 ml The active ingredient (s) used according to the invention is dispersed in the saturated triglycerides. Then the soya lecithin is added under stirring, and subsequent to this, the aqueous solution of sodium hydroxide is added with subsequent homogenization. The dispersion is sterilized and filled into 10 ml vials. A vial contains 50 mg of the compound according to the invention. d) Biodegradable Parenteral Depot Medicinal Form active ingredient used according to the invention 10.000 g polylactic acid /polygylcolic acid polymer 70.000 g polyvinylpyrrolidone 0.200 g gelatine 2.000 g soya lecithin 2.000 g isotonic sodium chloride solution to 1000.000 ml First, the active ingredient is incorporated into the biodegradable polymer comprising polylactic acid and polyglycolic acid by a suitable method (spray drying, solvent-evaporation or phase separation) and subsequently subjected to a sterilization process. The particles are introduced into a 2 -chamber ready-made syringe in which the adjuvant solution, which is also produced in a sterile manner, is filled. The biodegradable microparticles are mixed with the dispersion agent shortly before application and dispersed. A ready-made syringe contains 200 mg of the active compound according to the invention. e) Parenteral Dispersion for Subcutaneous Instillation active ingredient used according to the invention 25,000 g soya lecithin 25,000 g arachis oil 400,000 g benzyl alcohol 50,000 g Miglyole ® to 1000,000 g The active ingredient is dispersed together with soya lecithin and arachis oil. The benzyl alcohol is dissolved in Miglyole and added to the dispersion. The entire dispersion is sterilized and subsequently filled into vials with 2 ml content. A vial contains 50 mg active ingredient. f) Parenteral Perfusions Solution The solution named under example b) can also be used for perfusion of liver for example. According to need, instead of ampules with injection solution, so-called perforation bottles (vials) , which can also be optionally preserved, and infusion solutions with an amount of one or more active ingredients according to the invention can also be made available in the customary manner under addition of buffer substances for adjustment of physiological pH value and/or the isotonicity and/or a best possible suitable pH value for the medicinal form (euhydria) and optional further required nutrients, vitamins, amino acids, stablizers and other necessary adjuvants, possibly in combination with further medicinal agents suitable for the mentioned indications. 2 . Solid, Peroral Administrable Medicaments a) Tablets active ingredient used according to the invention 10.000 g lactose 5.200 g starch, soluble 1.800 g hydroxypropylmethylcellulose 900 g magnesium stearate 100 g The above components are mixed with each other and compacted in a conventional manner, wherein a tablet weight of 180 mg is set. Each tablet contains 100 mg active ingredient. If desired, the tablets obtained in this manner are coated, provided with a film coat and/or enterically coated. b) Coated Tablet Core active ingredient used according to the invention 10.000 g flame dispersed silicon dioxide 500 g corn starch 2.250 g stearic acid 350 g ethanol 3.0 1 gelatine 900 g purified water 10.0 1 talcum 300 g magnesium stearate 180 g From these components, a granulate is produced which is pressed to the desired coated tablet cores . Each core contains 50 mg of active ingredient. The core can be further processed in a customary manner to coated tablets. If desired, a gastric fluid resistant or retarding film coat can be applied in a known manner. c) Vials for Drinking active ingredient used according to the invention 0.050 g glycerine 0.500 g sorbite, 70% solution 0.500 g sodium saccharinate 0.010 g methyl-p-hydroxybenzoate 0.040 g aromatic agent q.s. sterile water q.s. to 5 ml The above-mentioned components are mixed in a customary manner to a suspension and filled in a suitable drink vial having 5 ml content . d) Poorly Soluble Sublingual Tablets active ingredient used according to the invention 0.030 g lactose 0.100 g stearic acid 0.004 g talcum puru 0.015 g sweetener q.s. aromatic agent q.s. rice starch q.s. to 0.500 g The active ingredient is compacted together with the adjuvants under high pressure to sublingual tablets, favourably in oblong form. e) Soft Gel Capsule active ingredient used according to the invention 0.050 g fatty acid glyceride mixture (Miglyole ® ) q.s. to 0.500 g The active ingredient is impasted together with the fluid carrier mixture and mixed together with further adjuvants suitable for the encapsulation and filled into elastic soft gelatine capsules which are sealed. f) Hard Gelatine Capsules active ingredient used according to the invention 0.150 g microcrystalline cellulose 0.100 g hydroxypropylmethylcellulose 0.030 g mannite 0.100 g ethylcellulose 0.050 g triethyl citrate 0.010 g The active ingredient is mixed together with the adjuvants, microcrystalline cellulose, hydroxypropylmethylcellulose and mannite, wet with granulation liquid and formed into pellets. These are subsequently coated with a solution of ethylcellulose and triethyl citrate in organic solvents in a fluidized-bed apparatus. A hard gelatine capsule contains 150 mg of active ingredient. 3. Topically Administrable Medicinal Forms a) Hydrophilic Ointment active ingredient used according to the invention 0.500 g Eucerinum anhydricum 60.000 g microcrystalline wax 15.000 g Vaseline oil q.s. to 100.000 g The above-mentioned adjuvants are melted and further processed together with the active ingredient to an ointment in a customary manner. b) Lipophilic Ointment active ingredient used according to the invention 10.000 g propylene glycol 50.000 g paraffin, liquid 100.000 g paraffin wax 100.000 g Vaseline to 1000.000 ml The active ingredient (s) used according to the invention is dissolved in propylene glycol at ca. 60 °C. At the same time, the lipophilic components are melted at 60-70°C and subsequently combined with the active ingredient solution. The ointment is emulsified at first at 60-70°C and subsequently cooled to 35-40°C under constant emulsification and then filled in 10 g tubes. A tube contains 100 mg of the compound according to the invention. 4. Inhalation Therapeutic Agent Further subject-matter is a pharmaceutical formulation which is characterized in that it contains an active ingredient (s) used according to the invention as a base or a physiologically acceptable salt thereof together with carriers and/or diluents customary for this and suitable for administration by means of inhalation. In connection with the production of the medicaments, particularly suitable physiologically acceptable salts of the active ingredients are, as already illustrated in the synthesis section, acid addition salts derived from inorganic or organic acids such as for example especially hydrochloride, hydrobromide, sulfate, phosphate, maleate, tartrate, citrate, benzoate, 4-methoxybenzoate, 2- or 4- hydroxybenzoate, 4-chlorobenzoate, p-tosylate, methane sulfonate, ascorbate, salicylate, acetate, formate, succinate, lactate, glutarate, gluconate or tricarballylate . The administration of the active ingredient (s) used of the invention by means of inhalation occurs according to the invention in conventional ways customary for administrations of this form, for example in the form of a commercial controlled dosage aerosol or in combination with a spacer. In controlled dosage aerosols, a metering valve is delivered with whose help, a dosed amount of the composition is administered. For spraying, the present compositions can be formulated for example as aqueous solutions or suspensions and be administered by means of an atomizer. Aerosol spray formulations in which the active ingredient is either suspended with one or two stabilizers in a propellant as a carrier and/or diluent, for example tetrafluoroethane or HFC 134a and/or heptafluoropropane or HFC 227 can equally be used, whereby however, non-fluorinated hydrocarbons or other propellants which are gaseous at normal pressure and room temperature, such as propane, butane or dimethyl ether, can be preferred. Thereby, propellant-free manual pump systems or dry powder systems as described below can also be used. Suitably, the propellant aerosols can also contain surface active adjuvants, such as for example isopropyl myristate, polyoxyethylene sorbitan fatty acid ester, sorbitan trioleate, lecithins, oleic acid. For administration by means of inhalation and/or insufflation, the medicaments with an amount of compounds according to the invention can also be formulated in the form of dry powder compositions, for example as active ingredient- soft pellets or as an active ingredient-powder mixture with a suitable carrier, such as for example lactose and/or glucose. The powder compositions can be formulated and administered as single doses or as multiple doses. The compounds according to the invention are preferably administered by means of a controlled dosage aerosol or in the form of a dry powder dosage formulation, wherein the latter preferably contains glucose and/or lactose as a carrier substance . As applicators for inhalation of the pharmaceutical formulations containing one or more of the active ingredient (ε) used according to the invention, all applicators are generally suitable which are suitable for controlled dosage aerosols and/or a dry powder dosage formulation, such as for example usual applicators for the nose, mouth and or pharynx, or also devices standing under propellant gas for the delivery of a spray (as controlled dosage aerosol or dry powder dosage formulation) as they are also used for inhalations in the nose, mouth and/or pharynx. A further embodiment can also consist of an aqueous solution of the active ingredient (s) used according to the invention, which also optionally contains further active ingredients and/or additives, which are applied by means of an ultrasound atomizer. a) Controlled Dosage Aerosol Intended dose per aerosol per stroke % by weight active ingredient used according to the invention 0.500 mg 0.66 stabilizer 0.075 mg 0.10 HFC 134a 75.500 mg 99.24 b) Controlled Dosage Aerosol Intended dose per aerosol per stroke % by weight active ingredient used according to the invention 0.250 mg 0.32 Stabilizer 0.038 mg 0.05 HFC 227 79.180 mg 99.63 In the examples a) and b) the micronized active ingredient is, after previous dispersion in a small amount of the stabilizer, placed in a suspenεion veεεel in which the bulk amount of propellant gas solution is found. The corresponding suspension is dispersed by means of a suitable stirring syεtem (for example high performance mixer or ultraεound mixer) until an ultra-fine diεpersion resultε. The εuεpension iε then continuouεly held in flux in a filling apparatuε εuitable for cold propellantε or preεεure fillings. Alternatively, the εuεpenεion can alεo be produced in a suitable cooled stabilizer εolution in HFC 134a/227. The exampleε c) to d) deεcribe the composition and production of doεage dry powder formulations. c) Dosage-Dry Powder Formulation mg/doεe active ingredient uεed according to the invention 0.500 mg d) Dosage-Dry Powder Formulation mg/dose active ingredient used according to the invention 0.500 mg lactose Ph.Eur. to 2.5 mg or to 5.0 mg e) Dosage-Dry Powder Formulation mg/doεe active ingredient uεed according to the invention 0.250 mg lactoεe Ph.Eur. to 2.5 mg or to 5.0 mg In example c) the active ingredient iε formulated after micronization under addition of steam as pellets with an MMAD between 0 , 1 and 0 , 3 mm diameter and brought to use in a multi-dose powder applicator. In the examples d) and e) the active ingredient is micronized, thereafter, bulk material is mixed with the lactoεe in the given amountε, and subsequently, filled in a multi-dose powder inhalator. In all of the examples set forth above, the active ingredient or the medicinal agent in the form of the respective εuitable pharmaceutical acceptable εalt and/or acid addition εaltε can be present, insofar aε the baεe iε not preferred in each case . PHARMACEUTICAL EXPERIMENTAL SECTION 1. Growth Inhibition of Human Tumor Cells The tumor growth inhibiting activity of the substances was determined on human tumor cells in standardized in vitro test syεtems . In the screening tests, the subεtanceε gave IC 50 - values in a concentration range of 0.1 nM to 10 μlΛ . Example 1 HepG2 cellε derived from a human liver carcinoma plated at a denεity of 20,000 cellε/ml in 12-well plaεtic disheε. Cultivation occurred in Richterε IMEM-ZO nutrient medium with 5% foetal calf εerum (FCS) in a tiεεue culture incubator with a gaε mixture of 5% C0 2 and 95% air at a temperature of 37°C. One day after plating, the culture medium waε aεpirated from the cellε and replaced by fresh medium which contained the respective concentrations of the test subεtances. For the individual concentrations and the controlε without teεt εubεtanceε, three-fold batches were done for each. Three dayε after the beginning of treatment, the medium was again renewed with the test compounds. After εix dayε of substance incubation, the test waε ended and the protein amount in the individual wells waε determined with the sulforhodamin-B-method (according to P. Skehan et al . : New Colorimetric Cytotoxicity Aεεay for Anticancer-Drug Screening. J. Natl . Cancer Inst. 82: 1107-1112, 1990). The IC 50 -values (defined aε that concentration in which the cell growth was inhibited by 50%) was taken from the doεe-reεponse curves and given as a comparative measurement for the activity of the test compounds. The results obtained are depicted in the following Table: Example 2 A549 cells derived from a human lung carcinoma plated at a density of 20,000 cells/ml in 12-well plaεtic dishes. Cultivation occurred in Richters IMEM-ZO nutrient medium with 5% foetal calf serum (FCS) in a tissue culture incubator with a gas mixture of 5% C0 2 and 95% air at a temperature of 37°C. One day after plating, the culture medium was aspirated from the cells and replaced by fresh medium which contained the respective concentrations of the test subεtances . For the individual concentrations and the controls without test subεtanceε, three- fold batches were done for each. Three days after the beginning of treatment, the medium was again renewed with the test compounds . After four dayε of substance incubation, the test was ended and the protein amount in the individual wells was determined with the sulforhodamin-B-method (according to P. Skehan et al . : New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening. J. Natl. Cancer Inst. 82: 1107-1112, 1990). The IC 5Q -values (defined as that concentration in which the cell growth waε inhibited by 50%) waε taken from the doεe-reεponεe curves and given aε a comparative meaεurement for the activity of the teεt compoundε . The following results were obtained: Example 3 HT-29 cells derived from a human colon carcinoma plated at a density of 20,000 eelIs/ml in 12-well plastic dishes. Cultivation occurred in Richters IMEM-ZO nutrient medium with 5% foetal calf serum (FCS) in a tisεue culture incubator with a gaε mixture of 5% C0 2 and 95% air at a temperature of 37°C. One day after plating, the culture medium waε aεpirated from the cellε and replaced by fresh medium which contained the respective concentrations of the test subεtances . For the individual concentrations and the controls without test substances, three-fold batches were done for each. Three days after the beginning of treatment, the medium waε again renewed with the test compounds. After four days of subεtance incubation, the teεt was ended and the protein amount in the individual wells was determined with the sulforhodamin-B- method (according to P. Skehan et al . : New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening. J. Natl. Cancer Inst. 82: 1107-1112, 1990). The IC 50 -values (defined aε that concentration in which the cell growth waε inhibited by 50%) waε taken from the doεe-response curveε and given as a comparative meaεurement for the activity of the teεt compoundε . The following reεults were obtained: Example 4 THP-1 cellε derived from a human monocytic leukemia plated at a denεity of 200,000 cellε/ml in 96-well plastic disheε . Cultivation occurred in RPMI 1640 nutrient medium with 10% foetal calf εerum (FCS) in a tissue culture incubator with a gas mixture of 5% C0 2 and 95% air at a temperature of 37°C. For the individual concentrations and the controls without teεt substances as well as for the background with nutrient medium but without cells, three-fold batches were done for each. After four days of εubεtance incubation 20 μl WST-1 reagent (Boehringer Mannheim) was respectfully pipetted in each individual well. After 30 to 60 minute incubation in the tisεue culture incubator at 37°C and 5% C0 2 , the light extinction waε meaεured in an ELISA reader at 450 nm wave length. The backgroundε were each subtracted from the typical measured valves. (The IC 50 -values (defined as that concentration in which the cell growth was inhibited by 50%) was taken from the doεe-reεponεe curveε and given aε a comparative measurement for the activity of the test compounds . The following reεults were obtained: Indications The compoundε of formula (I) and their εaltε permit a therapeutic use in malignant illnesεeε of humanε and animals through their excellent inhibition of the growth of tumor cellε. The anti-neoplastic activity of the described εubεtances can be used for prophylactic, adjunct, palliative, and curative treatment of solid tumors, leukemic illnesεeε and lymphomaε aε well aε for decreaεing or preventing metaεtaεis formation in humanε and animals. The therapeutic use is poεεible in the following illneεεeε for example: gynaecological tu orε, ovarian carcinomaε, teεticle tumorε, proεtate carcinomas, skin cancer, kidney cancer, bladder tumors, oesophaguε carcinomas, εtomach cancer, rectal carcinomaε, pancreas carcinomas, thyroid cancer, adrenal tumorε, leukemia and lymphomaε, Hodgkin'ε diεeaεe, tumor illneεεeε of the CNS, εoft-tiεεue εarcomaε, bone εarcomas, benign and malignant mesotheliomaε, but eεpecially inteεtine cancer, liver cancer, breaεt cancer, bronchial and lung carcinomaε, melanomaε, . acute and chronic leukemiaε . Benign papillomatoεis tumorε can also be limited in their growth with the named εubstanceε . The broad effectiveneεε of the new compounds were tested for example in very different human tumor cells in vitro according to the methods described in point 1. Thereby, the following IC 50 valves were obtained for the compound Nr. 119: The novelty of the compoundε can be expected to have an independent activity profile in the effectiveness against the various tumor types. Thus, tumorε which are resistant to customary cytostatic agents, for example, can respond entirely to these subεtanceε . In addition, based on the independent characteristicε, combinationε of the new compoundε with known pharmaceuticals used in chemotherapy are promiεing aε long aε their propertieε are complimented in a εuitable manner. The integration of the new structures in a therapy scheme could be succeεsful with one or more εubstances from the following claεεes for example: anti- metabolites (for example cytarabine, 5-fluorouracil, 6- mercaptopurine, methotrexate) , alkylating agents (for example busulfane, carmustine, ciεplatin, carboplatin, cyclophosphamide, dacarbazine, melphalane, thiotepa) , DNA- intercalating subεtanceε and topoiεomerase inhibitors (for example actinomycin D, daunorubicin, doxorubicin, mitomycin C, mitoxantrone, etoposide, teniposide, topotecane, irinotecane) , spindle poisons (for example vincristine, navelbine, taxol, taxoter) , hormonally active agents (for example tamoxifene, flutamide, formeεtane, gosereline) or other cytoεtatic agents with complex modes of action (for example L-aεparaginase, bleomycin, hydroxyurea) . Resiεtant tumor cellε can be made senεitive again for example by interaction of the new compoundε with a mechaniεm of reεistance for common cytoεtatic agents (for example P- glycoprotein, MRP, glutathione-S-tranεferase, metallothionein) . 3. Immuno Suppressing Activity Many anti-tumor agents have not only a cytotoxic effect on tumor cellε, but alεo on the blood cell εyεtem. Thiε leadε to a weakening of the immune defence, which can, in turn, be specifically employed to εuppreεs the rejection reaction after an organ transplantation for example. Also use of the main compounds, optionally in combination with other immunological diseaεeε (for example, pεoriasis or autoimmune diεeaεes) seems likely. In order to test the posεibility for a therapeutic use in illnesεeε of this type, the εubstance activity waε tested on freshly isolated lymphocyteε aε follows : The spleen of a Swiss mouse served aε a lymphocyte εource . The lymphocyte population was isolated from the spleen cell εuεpenεion over a ficoll gradient and taken up in IMEM-ZO culture medium with 0,1% dextran 70,000 and 2% foetal calf εerum. The cells were plated at a density of ca . 500,000 cells/well/ml in a 12-well plate, 1 ml doubly concentrated test εubstance solution was pipetted per well and this waε εubsequently incubated in a tissue culture incubator at 37°C and 5% C0 2 - After 2 days, a 1 ml-aliquot with 5 μl of the fluorescent dye solutions propidium iodide (8 mg/ml) and 3 , 3 ' -dihexyloxacarbocyanin iodide (40 μg/ml) each was added per well, and incubated for 3 minutes at room temperature. Subsequently, 10,000 cells per each εample were measured on a flow-through cytometer and the percentage amount of vital cells in the population was determined. By means of the dose- response curveε, IC 5 o-valueε were calculated which were alεo employed in the following Tableε for the characterization of the individual εubεtance : The independent εtructural class of the compounds can also be expected to be εuccesεful for an efficient combination with known immunoεuppreεεive agents εuch aε for example cycloεporin A, tacrolimus, rapamycin, azathioprine and glucocorticoidε .

Claims: , _- CLAIMS 1. Compounds of the general formula (I) (I) wherein R 1 is selected from hydrogen, hydroxy, halogen, cyano, aminocarbonyl, carboxy, saturated, single or several-fold unsaturated, branched or εtraight chained or cyclic hydrocarbon reεidues such as alkyl, alkenyl, alkinyl or cycloalkyl, aryl such as phenyl or heteroaryl such as pyridyl, alkoxy, cycloalkyloxy, alkenyloxy or alkinyloxy or aralkyloxy such as the benzyloxy group, alkoxycarbonyl, alkylaminocarbonyl , dialkylaminocarbonyl, alkanoyloxy, alkoxycarbonyloxy, alkylthio, cycloalkylthio, alkenylthio, alkinylthio, aryloxy such as phenoxy, heteroaryloxy such aε pyridyloxy, arylthio εuch aε phenylthio, heteroarylthio such as pyridylthio, trifluoromethyl , hydroxyalkyl , NR 5 R 6 , wherein R 5 and 6 are selected independent of each other from hydrogen, εaturated or unsaturated hydrocarbon residues such as alkyl, alkenyl, alkinyl, or aryl such as phenyl and aralkyl such as benzyl ; R 2 is selected from hydrogen, halogen, cyano, εaturated hydrocarbon reεidueε εuch as alkyl, or halogenated hydrocarbon residues such aε trifluoromethyl, hydroxy, alkoxy, aralkyloxy reεidues εuch as benzyloxy, as well as alkanoyloxy, whereby R 1 and R 2 , in the case that they are immediately adjacent to each other, optionally form a bridge which iε selected from -(CH 2 )4- and -(CH=CH) 2 - and -CH 2 0-CR 7 R 8 -0- , wherein R 7 and 8 are selected independently of each other from hydrogen and alkyl reεidueε; R 3 is selected from Hydrogen, halogen, εaturated hydrocarbon reεidues such as alkyl, or halogenated hydrocarbon reεidueε such as trifluoromethyl, or hydroxyalkyl; 4 iε εelected from hydrogen, hydroxy, or single or εeveral-fold unsaturated, branched or straight chained or cyclic hydrocarbon residues such as alkyl, alkenyl, alkinyl or cycloalkyl, alkoxy and aralkyloxy such as benzyloxy; k iε 0 or 1; A is εelected from Alkylene, which iε optionally εubstituted one to threefold by straight chained or branched chained hydrocarbon reεidueε εuch aε alkyl, hydroxy, alkoxy, halogen εuch aε fluorine, or aryl εuch aε phenyl, Alkylene, wherein a methylene unit iε isoεterically replaced by 0, S, NR 9 , CO, SO or S0 2 whereby, with the exception of CO, the isosteric substitution cannot be adjacent to the amide group and, in NR 9 , the residue R 9 is εelected from hydrogen, alkyl, alkenyl, alkinyl, acyl or alkanesulfonyl; Cycloalkylene such as 1, 2-cyclopropylene,- Alkenylene which is optionally substituted one to threefold by alkyl, hydroxy, alkoxy, fluorine cyano or aryl such aε phenyl ,- Alkadienylene, which iε optionally substituted once or twice-fold by alkyl, fluorine, cyano or aryl such as phenyl, 1, 3 , 5-hexatrienylene, which is optionally substituted by alkyl, fluorine, cyano or aryl such as phenyl , and ethinylene; D is εelected from alkylene, which is optionally εubεtituted once or twice by alkyl, hydroxy, or alkoxy,- alkenylene, which iε optionally εubstituted once or twice by alkyl, hydroxy, or alkoxy,- alkinylene, which is optionally substituted once or twice by alkyl, hydroxy, or alkoxy, as well as alkylene, alkenylene or alkinylene, wherein one to three methylene units iε each isosterically replaced by O, S, NR 10 , CO, SO or S0 2 , wherein R 10 has the same meaning aε R 9 but iε εelected independently thereof ,- E whereby q iε 1, 2 or 3; R 11 is selected from hydrogen, alkyl, hydroxy, hydroxymethyl, carboxy, or alkoxycarbonyl and R- 1 - 2 is selected from hydrogen, alkyl or an oxo group immediately adjacent to a nitrogen atom or R 11 and R 12 optionally together, form an alkylene bridge under formation of a bicyclic ring systemε,- G iε εelected from Gl, G2 , G3 , G4 or G5 , wherein G 1 is (CH 2 ) r (CR 14 R 15 ) S R 13 (Gl) whereby r has the meaning 0 to 3 , s is 0 or 1; R 13 is εelected from hydrogen, alkyl, alkenyl, alkinyl, cycloalkyl; εaturated or unεaturated, four to eight-membered heterocycleε which can contain one or two hetero-atoms that are selected from N and/or S and /or 0; benzyl , phenyl ,- monocyclic aromatic five- or six-membered heterocycleε which can contain 1 to 3 hetero-atoms that are selected from N and/or S and/or 0 and are either directly bound or bound over a methelyene group; anellated bi- and tricyclic aromatic or partially hydrated carbocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, whereby the bond can occur either over an aromatic or a hydrated ring and either directly or over a methylene group; anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring systemε with 8 to 16 ring atoms and at leaεt one aromatic ring, whereby one to three ring atoms can be selected from N and/or S and/or 0 and the bond can occur either over an aromatic or a hydrated ring and either directly or over a methylene group,- R 14 has the same meaning as R 13 but is selected independently thereof ; R 15 is selected from hydrogen, hydroxy, Cτ_-C 3 -alkyl, aralkyl εuch aε benzyl or aryl εuch as phenyl , monocyclic aromatic five or six-membered heterocycles, which can contain one to three hetero-atomε εelected from the group N and/or S and/or O and are either bound directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated carbocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring systemε with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be εelected from N and/or S and/or 0 and the linkage can occur either over an aromatic ring or a hydrated ring and either directly or over a methylene group, with the exception of compoundε in which G has the meaning (CH 2 ) r (CR 14 R 15 ) S R 13 {G1) in the caεe that the following εubεtitutents are simultaneouεly signify R 13 pyridyl or (optionally halogen-, alkyl-, alkoxy- or Trifluoromethyl-εubεtituted) phenyl , R 14 hydrogen or (phenyl optionally εubεtituted with halogen-, alkyl-, alkoxy- or Trifluoro methyl, R 15 is hydrogen, and A representε alkylene, optionally εubstituted ethenylene or butadienylene, D alkylene or alkenylene aε well as E piperazine or homopiperazine and S = 1; is selected from (G2a) or whereby r and s as well as the subεtitutents R- 1 - 3 to R- 1 - 5 can have the above meaning, or the grouping NR 13 R 15 can also be a nitrogen heterocycle bound over the nitrogen atom selected from saturated or unsaturated monocyclic, four to eight- membered heterocycles, which , aside from the esεential nitrogen atom, can εtill optionally contain one or two further hetero-atoms selected from N and/or S and/or 0, or saturated or unsaturated bi- or tricyclic, anellated or bridged heterocycles with 8 to 16 ring atoms, that aside from the esεential nitrogen atom, can optionally εtill contain one or two further hetero-atoms that are εelected from N and/or S and/or 0; G 3 has the meaning S0 2 {CH 2 ) r R 13 (G3) wherein r and R 3 - 3 have the above definition, G 4 has the meaning whereby Ar 1 and Ar 2 can be selected independently from each other from phenyl, pyridyl or naphthyl; has the meaning whereby !6 is εelected from trifluoromethyl, alkoxy, alkenyloxy, and aralkyloxy such as benzyloxy, whereby aromatic ring syεtemε in the substitutentε R 1 , R 2 , R 4 , R 5 , R 6 , R 13 , R 14 , R 15 , R 16 , Ar 1 and Ar 2 and/or in the ring εyεtem NR'^R 10 can be εubεtituted independently from each other by one to three of the εame or different groupε εelected from halogen, cyano, alkyl, halogen alkyl εuch as trifluoromethyl , cycloalkyl, aryl such as phenyl, arylalkyl such as benzyl; hydroxy, hydroxy alkyl, alkoxy, alkoxy entirely or partially substituted by fluorine, aralkyloxy such as benzyloxy, aryloxy such aε phenoxy; mercapto, alkylthio, carboxy, carboxyalkyl , carboxyalkenyl , alkoxycarbonyl , aralkyloxycarbonyl εuch as benzyloxycarbonyl, nitro, amino, monoalkylamino, dialkylamino and in the caεe of two adjacent reεidues on the aromatic ring, alεo methylendioxy, and whereby alkyl-, alkenyl- and cycloalkyl residueε in the groupε G 1 , G 2 and G 3 can be εubstituted by one or two of the same or different groupε which are selected from hydroxy, carboxy, alkoxycarbonyl, aralkyloxycarbonyl such aε benzyloxycarbonyl, amino, monoalkylamino and dialkylamino,- their ciε- and tranε-isomers , E- and Z-isomerε, especially in case that A is a cyclopropane ring or D contains one or more double bonds, including the enantiomers, diastereomers and other iεomerε aε well aε their racemic or non-racemic mixtures and the corresponding endo- and exo-isomers for the case that the ring system E is bicyclic; their tautomeres; their acid addition salts including their hydrates and solvates . 2. Pyridylalkane, pyridylalkene and pyridylalkine carboxamides of the formula (I) where in : . O R 1 is selected from hydrogen, halogen, cyano, Ci-Cg-alkyl, C3-Cg-alkenyl, C -Cg-alkinyl, trifluoromethyl, C3-Cg-cycloalkyl, C 1 -Cg- hydroxyalkyl , hydroxy, C 1 -Cg-alkoxy, C3-Cg-alkenyloxy, C3-Cg-alkinyloxy, benzyloxy, Ci-Cy-alkanoyloxy, C 2 -C7~ alkoxycarbonyloxy, C^ ^ -Cg-alkylthio, C3-Cg-alkenylthio, C3-Cg-alkinylthio, C3 -C3- cycloalkyloxy, C3~Cg- cycloalkylthio, C 2 -C7-alkoxycarbonyl , aminocarbonyl, C 2 - C -alkylaminocarbonyl, C3 -C^-dialkylaminocarbonyl , carboxy, phenyl, phenoxy, phenylthio, pyridyloxy, pyridylthio, and NR 5 R 6 , wherein R 5 and R > are εelected independently of each other from hydrogen, C^-C -alkyl, C3-C5-alkenyl, C3 -C -alkinyl , benzyl and phenyl ■ R 2 iε εelected from hydrogen, halogen, cyano, C^-Cg-alkyl, trifluoromethyl, hydroxy, C^-Cg-alkoxy, benzyloxy and C -C7-alkanoyloxy; R 1 and R 2 , if adjacent, optionally form a bridge εelected from -(CH 2 ) 4 - and -(CH=CH) 2 - or -CH 2 0-CR 7 R 8 -0- , wherein R 7 and R 8 are εelected independently from each other from hydrogen and C]_-Cg-alkyl; R 3 iε εelected from hydrogen, halogen, Ci-C -alkyl, trifluoromethyl and C^-Cg -hydroxyalkyl ,- R 4 iε εelected from hydrogen, Cx-Cg-alkyl, C 3 -Cg-alkenyl, C 3 -Cg-alkinyl, C 3 - Cg-cycloalkyl, hydroxy, C^Cg-alkoxy and benzyloxy; iε 0 or 1 , iε εelected from Cη_-Cg-alkylene, optionally εubεtituted one to three-fold by C . -C 3 -alkyl, hydroxy, C 3. -C 3 -alkoxy, fluorine, or phenyl , C 2 -Cg-alkylene, in which a methylene unit iε isosterically replaced by 0, S, NR 9 , CO, SO or S0 2 , whereby, with the exception of CO, the isoεteric substitution cannot be adjacent to the amide group and, in NR 9 , the residue R9 is selected from hydrogen, C^C - alkyl, C 3 -C -alkenyl , C 3 -Cg-alkinyl , Ci-Cg-acyl or Cη ^ - Cg-alkaneεulfonyl, 1,2-cyclopropylene, C 2 -Cg-Alkenylene, optionally subεtituted once to threefold by C 1 -C 3 -alkyl, hydroxy, C 1 -C 3 -alkoxy, fluorine, cyano or phenyl , C 4 -Cg-alkadienylene, optionally εubεtituted once to twofold by C -C 3 -alkyl, fluorine, cyano or phenyl; 1, 3, 5-hexatrienylene, optionally εubεtituted by C 1 -C3- alkyl, fluorine, cyano or phenyl, and ethinylene iε εelected from C 2 -C 1 Q-alkylene, optionally εubεtituted once or twice by Cη_-Cg-alkyl, hydroxy, or Cχ-Cg-alkoxy; C4-C10alkenylene, optionally εubεtituted once or twice by C -Cg-alkyl, hydroxy, or C ] _-Cg-alkoxy; C4-C10"alkinylene, optionally εubstituted once or twice by C^-Cg-alkyl, hydroxy, or C -Cg-alkoxy; aε well aε c 2"" c 10" alk y lene ' C4-C]_o -a lkenylene or C4-C 1 o _a lkinylene, in which one to three methylene units are iεoεterically replaced by 0, S, NR 10 , CO, SO or S0 2 , whereby R 10 haε the same meaning as R 9 , but is selected independently thereof; E signifies ) whereby q haε the meaning 1, 2 or 3; R 11 is selected from hydrogen, C^-Cg-alkyl, hydroxy, hydroxymethyl, carboxy, or C 2 -C7~alkoxycarbonyl and R- 1 - 2 is selected from hydrogen, C^-Cg-alkyl or an oxo group adjacent to a nitrogen atom, or R 11 and R- 1 - 2 optionally together, form a 1-C3 -alkylene bridge under formation of a bicyclic ring syεtem,- G is selected from Gl, G2 , G3 , G4 or G5 , whereby G 1 representε (CH 2 ) r (CR 14 R 15 )_ R 13 (Gl) r haε the meaning 0 to 3 , s is 0 or 1 and R 13 is selected from hydrogen, C^Cg-alkyl, C 3 -Cg-alkenyl , C 3 -Cg-alkinyl , C 3 - Cg -cycloalkyl ,- saturated or unsaturated, four to eight-membered heterocycleε, which can contain one or two hetero-atoms that are εelected from N and/or S and/or 0; benzyl , phenyl ,- monocyclic aromatic five or six-membered heterocycles, which can contain one to three hetero-atoms selected from the group N and/or S and/or 0 and are either bound directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated carbocyclic ring εyεtemε with 8 to 16 ring atoms and at leaεt one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring εyεtemε with 8 to 16 ring atoms and at leaεt one aromatic ring, wherein one to three ring atomε can be εelected from N and/or S and/or 0 and the linkage can occur either over an aromatic ring or a hydrated ring and either directly or over a methylene group, R 14 haε the εame meaning as R^ 3 , but is εelected independently thereof ,- R15 iε εelected from hydrogen, hydroxy, methyl, benzyl, phenyl, monocyclic aromatic five or εix-membered heterocycleε, which can contain one to three hetero-atoms from the group N and/or S and/or 0 and are either bound directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated carbocyclic ring syεtemε with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring syεtemε with 8 to 16 ring ato ε and at leaεt one aromatic ring, wherein one to three ring atomε can be selected from N and/or S and/or 0 and the linkage can occur either over an aromatic ring or a hydrated ring and either directly or over a methylene group, whereby G in the form of G- 1 - cannot have the meaning (CH 2 ) r (CR 14 R 15 ) S R 13 (Gl) in the case that the following subεtitutionε εimultaneouεly εignify R 13 pyridyl or (optionally halogen-, alkyl-, alkoxy- or Trifluoromethyl- εubstituted) phenyl , R 14 hydrogen or (phenyl optionally εubstituted with halogen-, alkyl-, alkoxy- or trifluoro methyl , R 15 is hydrogen, and A representε alkylene, optionally substituted ethenylene or butadienylene, D alkylene or alkenylene as well aε E piperazine or homopiperazine and s = 1; iε εelected from C (CH 2 ) r (CR 14 R 15 ) S R 1 3 O (G2a. or C (CH 2 ) r NR 13 R 15 ° (62b) whereby r and s aε well aε the εubεtitutentε R- 1 - 3 to R 15 can have the above meaning, or the grouping NR13 R 15 can alεo be a nitrogen heterocycle bound over the nitrogen atom εelected from εaturated or unεaturated monocyclic, four to eight- membered heterocycleε, which , aεide from the eεεential nitrogen atom, can optionally still contain one or two further hetero-atoms selected from N and/or S and/or 0, or εaturated or unεaturated bi- or tricyclic, anellated or bridged heterocycleε with 8 to 16 ring atomε, that aεide from the eεεential nitrogen atom, can optionally εtill loo contain one or two further hetero-atoms that are selected from N and/or S and/or 0; G 3 has the meaning S0 2 (CH 2 ) r R 13 (G3) wherein r and R 13 have the above definition, G 4 has the meaning \ ^Ar 1 whereby Ar 1 and Ar 2 can be selected independently from each other from phenyl, pyridyl or naphthyl; G 5 has the meaning COR 16 (G5) R!6 is selected from trifluoromethyl, C^-Cg-alkoxy, C3-Cg-alkenyloxy, and benzyloxy, whereby aromatic ring systems in the subεtitutentε are R 1 , R 2 , R 4 , R 5 , R 6 , R 13 , R 14 , R 15 , R 16 , Ar 1 and Ar 2 and/or in the ring εyεtem NR'^R 10 can be subεtituted independently from each other by one to three of the εame or different groupε εelected from halogen, cyano, C^-Cg-alkyl, trifluoromethyl, C3-C8- cycloalkyl, phenyl, benzyl, hydroxy, C^Cg -hydroxyalkyl, C^- Cg-alkoxy, C^-Cg-alkoxy entirely or partially εubstituted by fluorine, benzyloxy, phenoxy, mercapto, C ] _-Cg-alkylthio, carboxy, C 2 -C 7 -carboxyalkyl, C 2 -C7-carboxyalkenyl , C -C 7 - alkoxycarbonyl , benzyloxycarbonyl, nitro, amino, mono-C^-Cg- alkylamino, di- (C^-Cg-alkyl) -amino and, methylene dioxide for two adjacent residueε on the aromatic ring, and whereby alkyl-, alkenyl- and cycloalkyl reεidueε in the groups G 1 , G 2 and G 3 can be subεtituted by one or two of the same or different groups which are selected from hydroxy, carboxy, C 2 -C7-alkoxycarbonyl , benzyloxycarbonyl, amino, mono-Ci-Cg-alkylamino and di- (C ] _-Cg -alkyl -amino) ; their cis- and trans-iεomerε, E- and Z-isomers, especially in case that A iε a cyclopropane ring or D contains one or more double bonds, including the enantiomers, diaεtereomerε and other iεomers aε well as their race ic or non-racemic mixtures and the corresponding endo- and exo- isomers for the case that the ring syεtem E iε bicyclic,- their tautomereε,- aε well aε their acid addition εaltε including their hydrateε and εolvate . 3. Compound according to the claims 1 and 2, wherein the R 1 iε selected from hydrogen, halogen, cyano, C^-Cg-alkyl, trifluoromethyl , C3-Cg-cycloalkyl, 0χ-Cg-hydroxyalkyl , hydroxy, C 1 -C 4 - alkoxy, benzyloxy, C -C4-alkylthio, Cη_-C5-alkanoyloxy, C1-C4-alkylthio, C 2 -C5-alkoxycarbonyl, aminocarbonyl, C 2 -C5 -alkylaminocarbonyl , C3 -Cg -dialkylaminocarbonyl , carboxy, phenyl, phenoxy, phenylthio, pyridyloxy, and NR 5 R 6 , whereby R 5 and R 6 are selected independently from each other from hydrogen and 0χ-Cg-alkyl ; R 2 iε εelected from hydrogen, halogen, cyano, Cχ-Cg-alkyl, trifluoromethyl, hydroxy, C j _-C4-alkoxy; R 3 is εelected from hydrogen, halogen and C ] _-Cg-alkyl ,- R 4 is selected from hydrogen, Cχ-Cg-alkyl, C3-C 6 -alkenyl, C 3 -Cg-cycloalkyl, hydroxy, Cη_-Cg-alkoxy and benzyloxy,- k has the meaning 0 or 1, A is selected from Cη_-Cg-alkylene, optionally subεtituted one to three-fold by C 1 -C3-alkyl, hydroxy, fluorine, or phenyl, C 2 -Cg-alkylene, in which a methylene unit iε iεoεterically replaced by 0, S, NR 9 , CO, SO or S0 2 , whereby, with the exception of CO, the isoεteric εubstitution cannot be adjacent to the amide group and, in NR 9 , the residue R9 iε εelected from hydrogen, C^-Cg- alkyl, Ci-Cg-acyl or methane sulfonyl; 1,2-cyclopropylene, C 2 -Cg-Alkenylene, optionally substituted once to threefold by Cχ-C 3 -alkyl, hydroxy, fluorine, cyano or phenyl, C 4 -Cg-alkadienylene, optionally substituted once to twofold by Cχ-C 3 -alkyl, fluorine, cyano or phenyl; 1, 3, 5-hexatrienylene, optionally subεtituted by C 1 -C 3 - alkyl, fluorine, cyano, and ethinylene D is selected from C 2 -Cιo -a lkylene, optionally subεtituted once or twice by C 1 -C3-alkyl or hydroxy,- C4-C10 alkenylene, optionally εubstituted once or twice by C1-C3 -alkyl or hydroxy; C4-Cιo _a lkinylene, optionally subεtituted once or twice by C1-C3-alkyl or hydroxy; as well as C 2 -C3_o-alkylene, C4-C10 -alkenylene or C4-Cχo -all inylene, in which one to three methylene units is each isosterically replaced by 0, S, NR 10 , CO, SO or S0 2 , whereby R 10 has the same meaning aε R 9 , but iε selected independently thereof; E εignifies ) whereby q haε the meaning 1, 2 or 3 ,- R^ iε selected from hydrogen, C1-C3-alkyl, hydroxy, hydroxymethyl, carboxy, or C 2 -C7~alkoxycarbonyl and R iε εelected from hydrogen or an oxo group adjacent to a nitrogen atom or R 11 and R 12 , optionally together, form a C 1 -C 3 -alkylene bridge under formation of a bicyclic ring εyεtem; G is selected from Gl, G2 , G3 , G4 or G5 , whereby p G i represen « t_.ε ( CH 2*)r' (CR 14 R 15 ) /s ς R 13 ( lr G. ^ l) r has the meaning 0 to 2 , s is 0 or 1 and R 13 iε εelected from hydrogen, C^-Cg-alkyl, C 3 -Cg-alkenyl , C 3 ~Cg-alkinyl, C 3 - Cg-cycloalkyl; benzyl, phenyl; monocyclic aromatic five or six-membered heterocycleε, which can contain one to three hetero-atomε εelected from the group N and/or S and/or 0 and are either bound directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated carbocyclic ring εystems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring syεtemε with 8 to 16 ring atomε and at leaεt one aromatic ring, wherein one to three ring atomε can be selected from N and/or S and/or 0 and the linkage can occur either over an aromatic ring or a hydrated ring and either directly or over a methylene group, R 14 haε the same meaning aε R- 1 - 3 , but is selected independently thereof ,- R 15 is selected from hydrogen, hydroxy, methyl, benzyl, phenyl; monocyclic aromatic five or six-membered heterocycleε, which can contain one to three hetero-atomε εelected from the group N and/or S and/or 0 and are either bound directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated carbocyclic ring εyεtems with 8 to 16 ring atomε and at leaεt one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated heterocyclic ring εystems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from N and/or S and/or 0 and the linkage can occur either over an aromatic ring or a hydrated ring and either directly or over a methylene group,- G 2 is selected from C (CH 2 ) r (CR 14 R 15 ) S R 1: II O (G2a) or C (CH 2 ) r NR 13 R 15 ° (G2b) whereby r and s aε well aε the εubεtitutents R 13 to R 15 can have the above meaning, or the grouping N 13 R 15 can alεo be a nitrogen heterocycle bound over the nitrogen atom εelected from εaturated or unεaturated monocyclic, four to eight- membered heterocycleε, which, aside from the esεential nitrogen atom, can optionally εtill contain one or two further hetero-atoms εelected from N and/or S and/or 0, or saturated or unsaturated bi- or tricyclic, anellated or bridged heterocycleε with 8 to 16 ring atoms, that aside from the esεential nitrogen atom, can optionally still contain one or two further hetero-atoms that are selected from N and/or S and/or O; G 3 haε the meaning S0 2 (CH 2 ) r R 13 (G3) wherein r and R-^ 3 have the above definition, G 4 haε the meaning whereby Ar 1 and Ar 2 can be εelected independently from each other from phenyl , pyridyl or naphthyl ; haε the meaning COR 16 (G5) R!6 iε εelected from trifluoromethyl, C^-Cg-alkoxy, C3-Cg-alkenyloxy, and benzyloxy, whereby aromatic ring εystems in the substitutentε are R 1 , R 2 , R 4 , R 5 , R 6 , R 13 , R 14 , R 15 , R 16 , Ar 1 and Ar 2 and/or in the ring εyεtem NR 13 R 15 can be εubεtituted independently from each other by one to three of the same or different groupε εelected from halogen, cyano, C^-Cg-alkyl, trifluoromethyl, C3~C - cycloalkyl, phenyl, benzyl, hydroxy, C ] _-Cg-hydroxyalkyl , C^- Cg-alkoxy, Ci-Cg-alkoxy entirely or partially εubεtituted by fluorine, benzyloxy, phenoxy, mercapto, C ] _-Cg-alkylthio, carboxy, C 2 -C7-carboxyalkyl , C -C7-carboxyalkenyl , C 2 -C7~ alkoxycarbonyl , benzyloxycarbonyl, nitro, amino, mono-Ci-Cg- alkylamino, di- (C^-Cg-alkyl) -amino and, methylene dioxide in the caεe of two adjacent reεidueε on the aromatic ring, whereby alkyl-, alkenyl- and cycloalkyl reεidues in the groups G 1 , G 2 and G 3 can be substituted by one or two of the same or different groups which are selected from hydroxy, carboxy, C2-C7-alkoxycarbonyl, benzyloxycarbonyl, amino, mono-Cχ-Cg-alkylamino and di- (Cη_-Cg-alkyl -amino) . 4. Compounds according to claims 1-3, characterized in that R 1 iε εelected from hydrogen, halogen, cyano, methyl, ethyl, trifluoromethyl, hydroxy, C 1 -C 4 -alkoxy, benzyloxy, C^ - C 5 -alkanoyloxy, methylthio, ethylthio, methoxycarbonyl , tert-butoxycarbonyl aminocarbonyl, carboxy, phenoxy, and phenylthio R 2 is selected from hydrogen, halogen, trifluoromethyl, hydroxy; R 3 is selected from hydrogen, halogen; R 4 is selected from hydrogen, 02-03 -alkyl, allyl, hydroxy and, C^ , -C3-alkoxy,- k is 0 or 1, A is selected from C ] _-Cg-alkylene, optionally substituted once or twice by C 1 -C3-alkyl, hydroxy or fluorine; C -Cg-alkylene, in which a methylene unit is isosterically replaced by 0, S, NR 9 , CO, SO or S0 2 , whereby, with the exception of CO, the isoεteric εubstitution cannot be adjacent to the amide group, C 2 -Cg-alkylene, optionally subεtituted once or twice by c l" c 3 lkyl, hydroxy and/or fluorine; C4-Cg-alkadienylene, optionally substituted by C1-C3- alkyl or one or two fluorine atoms,- 1, 3 , 5-hexatrienylene, optionally subεtituted by, fluorine; D is εelected from C 2 -Cg -alkylene, optionally εubεtituted once or twice by methyl or hydroxy,- C4~Cg-alkenylene, optionally εubεtituted once or twice by methyl or hydroxy; C4-C -alkinylene, optionally substituted once or twice by methyl or hydroxy; and C 2 -C 8 -alkylene, C4~Cg-alkenylene or C 4 -Cg-alkinylene, wherein one to three methylene units are each isosterically replaced by 0, S, NH, N(CH 3 ) N(C0CH 3 ) , N(S0 2 CH 3 ), CO, SO or S0 2 , whereby E has the meaning whereby q is 1 or 2; R 11 iε εelected from hydrogen, Cχ-C3~alkyl, hydroxymethyl, or carboxy, and R 12 is εelected from hydrogen or an oxo group adjacent to a nitrogen atom G iε εelected from Gl, G2 , G3 , G4 or G5 , whereby G l — (CH 2 ) r — ( CR1 4 R15 )S — R1 3 (QI) repreεents r iε 0 to 2 and, s iε 0 or 1; and R 13 iε selected from hydrogen, Cη_-Cg-alkyl , C 3 -Cg-cycloalkyl ; benzyl, phenyl; benzocyclobutyl, indanyl, indenyl, oxoindanyl, naphthyl, dihydronaphthyl , tetrahydronaphthyl , oxotetrahydron- aphthyl, biphenylenyl, fluorenyl, oxofluorenyl, anthryl, dihydroanthryl , oxodihydroanthryl , dioxodihydroanthryl , phenanthryl , dihydrophenanthryl , oxodihydrophenanthryl , dibenzocycloheptenyl , oxodibenzocycloheptenyl , dihydrodibenzocycloheptenyl , oxodihydrodibenzocyclo- heptenyl, dihydrodibenzocyclooctenyl, tetrahydrodibenzo- cyclooctenyl or oxotetrahydrodibenzocyclooctenyl bound directly or over a methylene group,- furyl, thienyl, pyrrolyl , oxazolyl, isoxazolyl, thiazolyl, iso-thiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl , triazolyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, triazinyl, imidazothiazolyl, benzofuryl, dihydrobenzofuryl, benzothienyl, dihydrobenzothienyl , indolyl, indolinyl, iεoindolinyl, oxoindolinyl, dioxoindolinyl, benzoxazolyl, oxobenzooxazolinyl, benzooisoxazolyl , oxobenzoisoxazolinyl, benzothiazolyl, oxobenzthiazolinyl, benzoisothiazolyl, oxobenzoisothiazolinyl , benzoimidazolyl, oxobenzoimidazolinyl , indazolyl, oxoindazolinyl, benzofurazanyl, benzothiadiazolyl, benzotriazolyl, oxazolopyridyl, oxodihydrooxazolo- pyridyl, thiazolopyridyl , oxodihydrothiazolopyridyl , isothiazolopyridyl, imidazopyridyl, oxodihydroimidazo- pyridyl, pyrazolopyridyl , oxodihydropyrazolopyridyl , thienopyrimidinyl , chromanyl , chromanonyl , benzopyranyl , chromonyl, quinoloyl, isoquinoloyl , dihydroquinolyl , oxodihydroquinolinyl , tetrahydroquinolyl , oxotetrahydroquinolinyl , benzodioxanyl , quinoxalinyl , quinazolinyl, naphthyridinyl , carbazolyl, tetrahydrocarbazolyl , oxotetrahydrocarbazolyl , pyridoindolyl , acridinyl , oxodihydroacridinyl , phenanthridinyl , dihydrophenanthridinyl , oxodihydrophenanthridinyl , dibenzoiεoquinolinyl , dihydrodibenzoisoquinolinyl , oxodihydrodibenzo- iεoquinolinyl, phenothiazinyl , dihydrodibenzooxepinyl , oxodihydrodibenzooxepinyl , benzocycloheptathienyl , oxobenzocycloheptathienyl , dihydrothienobenzothiepinyl , oxodihydrothienobenzothiepinyl , dihydrodibenzothiepinyl , oxodihydrodibenzothiepinyl , octahydrodibenzothiepinyl , dibenzoazepinyl , dihydrodibenzoazepinyl , oxodihydrodibenzoazepinyl , octahydrodibenzoazepinyl , benzocycloheptapyridyl , oxobenzocycloheptapyridyl , pyridobenzoazepinyl , dihydropyridobenzoazepinyl , oxodihydropyridobenzoazepinyl , dihydropyridobenzo- diazepinyl , dihydrodibenzooxazepinyl , dihydropyridobenzooxepinyl , dihydropyridobenzo- oxazepinyl , oxodihydropyridobenzooxazepinyl , dihydrodibenzothiazepinyl , oxodihydrodibenzothiazepinyl , dihydropyridobenzothiazepinyl or oxodihydropyridobenzothiazepinyl bound directly or over a methylene group,- R 14 is εynonymous with R 13 but iε εelected independent thereof ,- R 15 is selected from hydroxy, methyl, benzyl, phenyl, indanyl, indenyl, naphthyl, dihydronaphthyl , tetrahydronaphthyl , furyl, thienyl, pyrrolyl , oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, triazinyl, benzofuryl, benzothienyl, indolyl, indolinyl, benzooxazolyl , benzothiazolyl, benzoimidazolyl, chromanyl, quinolyl or tetrahydroquinolyl bound directly or over a methylene group ,- G 2 iε εelected from C (CH 2 ) r (CR 14 R 15 ) £ ? 13 II (G2a) or C (CH 2 ) r NR 13 R 15 (G2b) whereby r and s and the substituentε R 13 to R 15 can have the above meaning, or the grouping NR 13 R 15 repreεents the ring of azetidine bound over the nitrogen or one of the following residueε: pyrrolidine, piperidine, (1H) -tetrahydropyridine, hexahydroazepine, (1H) -tetrahydroazepine, octahydroazocine, pyrazolidine, piperazine, hexahydrodiazepine, morpholine, hexahydro- oxazepine, thiomorpholine, thiomorphol in- 1, 1- dioxide, of 5-aza-bicyclo- [2.1.1] hexane, 2-aza- bicyclo [2.2.1] heptane, 7-aza-bicyclo- [2.2.1] heptane, 2 , 5-diaza-bicyclo [2.2.1] heptane, 2-aza-bi- cyclo [2.2.2] octane, 8-aza-bicyclo [3.2.1] octane, 2,5- diaza-bicyclo [2.2.2] octane, 9-aza-bicyclo [3.3.1] nonane, indoline, isoindoline, (1H) -dihydroquinoline, (1H)- tetrahydroquinolin, (2H) -tetrahydroisoquinoline, (1H) - tetrahydroquinoxaline, (4H) -dihydrobenzooxazine, (4H) - dihydrobenzothiazine, (1H) -tetrahydrobenzo [b] azepine, (1H) -tetrahydrobenzo [c] azepine, (1H) -tetrahydrobenzo [d] azepine, (5H) -tetrahydrobenzo [b] ox-azepine, (5H) -tetrahydrobenzo [b] thiazepine, 1,2,3, 4-tetra-hydro- 9H-pyrido[3,4-b] indole, (10H) -dihydroacridine, (10H) - dihydrophenanthr idine , 1,2,3,4- tet rahydroacridanone , (10H) -phenoxazine, (10H) -phenothiazine, (5H) - dibenzoazepine, (5H) -dihydrodibenzoazepine, (5H) - octahydrodibenzoazepine, dihydrobenzo [d, e] iεoquinoline, (5H) -dihydrodibenzodiazepine, (5H) -benzo [b] pyrido- [f] azepine, (5H) -Dihydrobenzo [b] pyri-do [f] azepine, (IIH) -Dihydrodibenzo [b, e] oxazepine, (IIH) - dihydrodibenzo [b, e] thiazepine, (10H) -dihydrodibenzo [b, f] -oxazepine, (10H) -dihydrodibenzo [b, f] thiazepine, (5H) -tetra-hydrodibenzoazocine, (IIH) - dihydrobenzo [e]pyrido [b] -1, 4-diazepin-6-one or (IIH) - Dihydrobenzo [b] pyrido [e] -1, 4-diazepin-5-one . G 3 S0 2 (CH 2 ) r R 13 (G3) wherein r and R 13 have the above definition, has the meaning whereby Ar 1 and Ar 2 are εelected independently from each other from phenyl , pyridyl or naphthyl ,- G 5 has the meaning R 1 ^ iε selected from trifluoromethyl, C 1 -Cg-alkoxy, C3-Cg-alkenyloxy, and benzyloxy, whereby aromatic ring syεtemε in the εubstitutents can be subεtituted independently from each other by one to three of the same or different groupε εelected from halogen, cyano, C]_-Cg-alkyl, trifluoromethyl , C3~Cg- cycloalkyl, phenyl, benzyl, hydroxy, Cg-alkoxy, C 1 -Cg-alkoxy entirely or partially εubεtituted by fluorine, benzyloxy, phenoxy, mercapto, C^-Cg-alkylthio, carboxy, C 2 -C 7 -carboxyalkyl, C -C 7 -carboxyalkenyl , C -C7~ alkoxycarbonyl , benzyloxycarbonyl, nitro, amino, mono-C^Cg- alkylamino, di- (C^-Cg-alkyl) -amino and, methylene dioxide in the case of two adjacent reεidueε on the aromatic ring, and whereby alkyl-, alkenyl- and cycloalkyl reεidueε in the groupε G 1 , G 2 and G 3 can be εubεtituted by one or two of the same or different groups which are selected from hydroxy, carboxy, C 2 -C7-alkoxycarbonyl, benzyloxycarbonyl, amino, mono-C;]_-Cg-alkylamino and di- (C^-Cg-alkyl-amino) . 5. Compounds according to claims 1-4, wherein R 1 is selected from hydrogen, fluorine, chlorine, bormine, methyl, ethyl, trifluoromethyl, hydroxy, C 1 -C 4 -alkoxy, methylthio, ethlythio, caroboxy and phenoxy; R 2 iε εelected from hydrogen, chlorine and methyl; R 3 iε hydrogen,- R 4 iε εelected from hydrogen, C 1 -C 3 -alkyl and hydroxy, k iε 0 A is selected from C 2 -Cg-alkylene, which iε optionally substituted once or twice by hydroxy or fluorine; C 2 -Cg-alkylene, wherein a methylene unit is isosterically replaced by 0, S or CO, whereby, with the exception of CO, the isosteric εubεtitution cannot be adjacent to the amide group,- C 2 -C 6 -alkenylene which iε optionally εubstituted by C^ C 3 -alkyl and/or fluorine,- C4-Cg-alkadienylene; D iε εelected from C 2 -C -alkylene which iε optionally εubεtituted by methyl or hydroxy; C4~Cg-alkenylene, which is optionally subεtituted by hydroxy ,- C4-Cg-alkinylene, which is optionally εubεtituted by hydroxy ,- C 2 -Cg-alkylene, C4~C -alkenylene, C4-Cg-alkinylene wherein a methylene unit iε reεpectively iεosterically replaced by 0, NH, N(CH3) , CO or S0 2 or an ethylene group is isoεterically replaced by a group NH-CO and/or CO-NH or a propylene group is iεoεterically replaced by a group NH-CO-0 and/or 0-CO-NH; E iε εelected from piperazine or hexahydro-1, 4-diazepine (homopiperazine) , wherein the ring can be optionally εubεtituted by one or two methyene groupε and/or by an oxo group adjacent to a nitrogen atom; G iε εelected from hydrogen, C3-C8-cycloalkyl, methoxy- carbonyl , tert-butoxycarbonyl, benzyloxycarbonyl, trifluoroacetyl, diphenylphosphinoyl , or a group —(CH 2 ) r —(CR 1 R 15 )—R 13 and and —C—(CH 2 )—NR 13 R 15 O and —SO 2 —(CH 2 ) r R 13 wherein has the meaning 0 or 1 : is 0 or 1, - 13 is selected from hydrogen, methyl, benzyl, phenyl, indanyl, indenyl, oxoindanyl, naphthyl, tetra- hydronaphthyl , fluorenyl, oxofluorenyl , anthryl, dihydroanthryl , oxodihydroanthryl , dioxodihydroanthryl , phenanthryl , dihydrophenanthryl , oxydihydrophenanthryl , dibenzocycloheptenyl , dihydrodibenzocycloheptenyl , oxodihydrodibenzocycloheptyl bound directly or over a methylene group, furyl , thienyl , oxazolyl, iεooxazoly, thiazolyl, imidazolyl, oxadiazolyl, pyridyl, pyrazinyl, pyrimidinyl, imidazothiazolyl, benzofuryl, benzothienyl, indolyl , indolinyl, oxoindolinyl, dioxoindolinyl, benzoxazolyl, oxobenzooxazolinyl , benzothiazolyl, oxobenzthiazolinyl, benzimidazolyl, oxobenzimidazolmyl, indazolyl, benzofurazanyl, benzotriazolyl, oxazolo- pyridyl, oxodihydrooxazolopyridyl, thiazolopyridyl , oxodihydrothiazolopyridyl , imidazopyridyl , oxodihydroimidazopyridyl, chromanyl, chromanonyl, benzopyranyl, chromonyl , quinolyl, iεoquinolyl, oxodihydroquinolinyl , tetrahydroquinolyl , oxotetrahydroquinolinyl, benzodioxanyl , quinazolinyl , carbazolyl, acridinyl, dihydroacridinyl , oxodihydro- acridinyl , dihydrophenanthridinyl dihydrobenzo iεoquinolinyl, phenothiazinyl, dihydrodibenzooxepinyl , benzocycloheptathienyl , dihydrothienobenzothiepinyl , dihydrodibenzothiepinyl , oxodihydrodibenzothiepinyl , dihydrodibenzoazepinyl , oxodihydrodibenzoazepinyl , octahydrodibenzoazepinyl , benzocycloheptapyridyl , dihydropyridobenzodiazepinyl , dihydrodibenzothiazepinyl bound directly or over a methylene group, R 14 iε selected from hydrogen, methyl, benzyl, phenyl; R 15 is selected from hydrogen, hydroxy, methyl, benzyl, phenyl ; naphthyl, tetrahydronaphthyl, furyl , thienyl, oxazolyl, thiazolyl, imidazolyl, pyridyl, benzofuryl, benzothienyl, indolyl, indolinyl, benzoxazolyl , benzothiazolyl, benzimidazolyl, chromanyl, quinolyl or tetrahydro- quinolyl bound directly or over a methylene group,- whereby the grouping -NR^R^ 5 represents a ring bound over the nitrogen atom of a residue from the series pyrrolidine, piperidine, hexahydroazepine, piperazine, hexahydrodiazepine, morpholine, hexahydroxazepine, thiomorpholine, 7-aza-bicyclo [2, 2.1] heptane, 2,5-diaza- bicyclo [2.2.1] heptane, indoline, isoindoline, (1H)- dihydroquinoline, (1H) -tetrahydroquinoline, (2H) - tetrahydroiεoquinoline, (4H) -dihydrobenzoxazine, (4H) - dihydrobenzothiazine, (1H) -tetrahydrobenzo [b] azepine, (1H) -tetrahydrobenzo [d] azepine, (5H) -tetrahydrobenzo [b] oxazepine, (5H) -tetrahydrobenzo [b] thiazepine, (10H) -dihydroacridine, 1,2,3, 4-tetrahydroacridanone, (10H) -dihydrophenanthridine, (1H) -dihydrobenzo- [d, e] iεoquinoline, (10H) -phenothiazine, (5H) - dibenzo [b, f] azepine, (5H) -dihydrodibenzo [b, f] azepine, (5H) -dihydrodibenzo [c, e] azepine, (5H) -dihydrodibenzo- diazepine, (IIH) -dihydrodibenzo [b, e] oxazepine (11H)- dihydrodibenzo [b, e] thiazepine, (5H) - dihydrobenzo [b] pyrido [3 , 2-f] azepine and (HH)-6- oxodihydrobenzo [e] pyrido [3, 2-b] [1, 4] diazepine, and whereby aromatic ring systemε in the εubεtituentε can be εubεtituted, independently of each other, by one to three of the εame or different groupε selected from halogen, cyano, C 1 -Cg-alkyl, trifluoromethyl , C3~C - cycloalkyl, phenyl, benzyl, hydroxy, 0χ-Cg-hydroxyalkyl , C^ L -Cg-alkoxy, Cχ-Cg-alkoxy which can be entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, C -Cg-alkylthio, carboxy, C 2 -C 7 -carboxyalkyl , C 2 -C 7 -carbocyalkenyl , C 2 -C 7 -alkoxycarbonyl , benzyloxycarbonyl, nitro, amino, mono-Ci-Cg-alkylamino or di- (C^-Cg-alkyl) -amino, and in the case of two adjacent residues on the aromatic ring, methylenedioxy, and whereby alkyl, alkenyl and cycloalkyl residues in the group G can be subεtituted by one or two of the εame or different groups which are selected from hydroxy, carboxy, C 2 -C 7 ~alkoxycarbonyl, benzyloxycarbonyl, amino, mono-C^-Cg-alkylamino and ki- (Cη_-C -alkyl) amino. 6. Compoundε according too the clai ε 1-5, wherein R 1 iε εelected from hydrogen, fluorine, methyl, trifluoromethyl ethylthio; R 2 , R 3 and R 4 are each hydrogen; k has the meaning 0, A iε εelected from ethylene, propylene or butylene which are each optionally substituted by hydroxy or one or two fluorine atomε ,- or 0CH 2 , SCH 2 . ethenylene, or 1,3 -butadienylene ,- D is selected from C 2 -Cg-alkylene which iε optionally εubεtituted by hydroxy; C4~Cg alkenylene; C 4 -Cg alkinylene,- or C 2 -Cg alkylene, C4~Cg alkenylene or C 4 ~Cg alkinylene, wherein one or two methylene unitε iε iεosterically replaced by 0, NH, CO or S0 2 ; E is selected from piperazine or hexahydro-1, 4- diazeazepine ,- G is εelected from phenyl , benzyl , phenethyl , diphenylmethyl , naphthyl , tetrahydronaphtyl, naphthyl ethyl , fluorenyl fluorenylmethyl , anthrylmethyl , dihydrodibenzo- cycloheptenyl ; furylmethyl , thienylmethyl , thiazolylmethyl , pyridylmethyl , benzothienylmethyl, quinolylmethyl , phenylthienylmethyl , phenylpyridylmethyl , benzocycloheptapyridinyl , dihydrobenzocyclo- heptapyridinyl , dihydrodibenzooxepinyl , dihydrodibenzothiepinyl , dihydrodibenzoazepinyl , dihdrobenzopyridodiazepinyl ; formyl, acetyl, pivaloyl, phenylacetyl, diphenylacetyl, diphenylpropionyl , naphthylacetyl, benzoyl, naphthoyl , oxofluorenylcarbonyl , oxodihydroanthrylcarbonyl , dioxodihydroanthrylcarbonyl , furoyl, pyridylacetyl , pyridylcarbonyl, chro onylcarbonyl , quinolylcarbonyl , phenylylaminocarbonyl , naphthylaminocarbonyl , tetrahydronaphthylaminocarbonyl , dibenzylaminocarbonyl , benzylphenylaminocarbonyl , diphenylaminocarbonyl , indolinyl -N- carbonyl , iεoindolin-N- carbonyl , tetrahydroquinolinyl-N-carbonyl , carbazolyl -N-carbonyl , tetrahydrobenzoazepinyl-N-carbonyl, dihydrodibenzoazepin-N-carbonyl , dihydrobenzopyridoazepinyl -N- carbonyl , oxodihydrobenzopyridoazepinyl-N-carbonyl ,- methanesulfonyl, toluenesulfonyl , naphthylsulfonyl, quinolinεulfonyl and diphenylphoεphinoyl , wherein aromatic ring εyεtems can be εubεtituted independently of each other by one to three of the εame or different groups which are selected from halogen, cyano, Cj_- Cg-alkyl, trifluoromethyl , C3~C - cycloalkyl, phenyl, benzyl, hydroxy, C^-C -hydroxyalkyl, C^-Cg-alkoxy, Cι~Cg-alkoxy entirely or partially subεtituted by fluorine, benzyloxy, phenoxy, mercapto, Cχ-Cg-alkylthio, carboxy, C 2 -C7~ carboxyalkyl , C 2 -C7-carboxyalkenyl, C 2 -C7-alkoxycarbonyl , benzyloxycarbonyl, nitro, amino, mono-C -Cg-alkylamino or di- (Cη_-Cg-alkyl) -amino, and in the case of two adjacent reεidueε in the aromatic ring methylenedioxy, and whereby alkyl, alkenyl and cycloalkyl reεidues in the group G can be subεtituted by one or two of the εame or different groups which are εelected from hydroxy, carboxy, C 2 -C7-.alkoxycarbonyl , benzyloxycarbonyl, amino, mono-C^-C -alkylamino or di- (C^-Cg-alkyl) -amino . 7. Compoundε according to formula (I) according to claim 1 or 2, characterized in that they are preεent in the form of the following compoundε : N- [4- (4-diphenylmethylpiperazin-l-yl) -3-hydroxybutyl] -3- pyridin- 3 -yl -acrylamide ,- N- [3- (4-diphenylmethylpiperazin-l-yl) -propoxy] -3 -pyridin-3- yl-acrylamide; N- [4- (4-diphenylmethylpiperazin-l-yl) -4-oxo-butyl] -3-pyridin- 3 -yl -acrylamide ,- N- [3- (4-diphenylmethylpiperazin-l-εulfonyl) -propyl] -3- pyridin-3 -yl -acrylamide ,- N-{2- [2- (4-diphenylmethylpiperazin-l-yl) -ethoxy] -ethyl} -3 -pyridin- 3 -yl -acrylamide ; N- (4- {4- [bis- (4-fluorphenyl) -methyl] -piperazin-l-yl} -but-2- in-yl) -3 -pyridin-3 -yl-acrylamide ,- N-{4- [4- (4-carboxyphenyl-phenylmethyl) -piperazin-l-yl] - butyl} -3 -pyridin-3 -yl-acrylamide and N- (4- {4- [ (4-aminophenyl) -phenylmethyl] -piperazin-l-yl} - butyl ) -3 -pyridin-3 -yl-acrylamide . N- {4- [4- (9H-fluoren-9-yl) -piperazin-l-yl] -butyl} -2- (pyridin- 3-yloxy) -acetamide; N-{5- [4- (9H-fluoren-9-yl) -piperazin-l-yl] -pentyl} -3 -pyridin- 3 -yl-acrylamide ,- N-{6- [4- (9H-fluoren-9-yl) -piperazin-l-yl] -hexyl} -3 -pyridin- 3 • yl-acrylamide; 3-pyridin-3-yl-N- {4- [4- (1,2,3, 4-tetrahydronaphthalin-l-yl) - piperazin-l-yl] -butyl} -acrylamide; - . „ 3-pyridin-3-yl-N-{4- [4- (5, 6, 7, 8-tetrahydronaphthalin-l-yl) - piperazin-l-yl] -butyl} -acrylamide and N- {4- [4- (naphthalin-1-yl) -piperazin-l-yl] -butyl} -3-pyridin-3- yl-acrylamide . N- [4- (4-biphenyl-2-yl-piperazin-l-yl) -butyl] -3 -pyridin-3 -yl- propionamide ,- N- [5- (4-biphenyl-2-yl-piperazin-l-yl) -pentyl] - 3-pyridin-3- yl-acrylamide; N- [6- (4-biphenyl-2-yl-piperazin-l-yl) -hexyl] -3-pyridin-3-yl- acrylamide; N- [4- (4-biphenyl-2-yl-piperazin-l-ly) -butyl] -2- (pyridin-3- yloxy) -acetamide as well as N- [4- (4-biphenyl-2-yl-piperazin-l-yl) -butyl] -5- (pyridin-3- yl) -penta-2, 4-diensaureamide . N- {4- [4- (10 , ll-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) - piperazin-l-yl] -butyl} -3 -pyridin-3 -yl -propionamide ; N-{5- [4- (10, ll-dihydro-5H-dibenzo[a,d] cyclohepten-5-yl) - piper-azin-1-yl] -pentyl} -3-pyridin-3-yl-acrylamide; N-{6- [4- (10, ll-dihydro-5H-dibenzo [a,d] cyclohepten-5-yl) - piper-azin-1-yl] -hexyl} -3 -pyridin-3-yl-acrylamide ,- N-{4- [4- (10, ll-dihydro-5H-dibenzo [a,d] cyclohepten-5-yl) - piper-azin-1-yl] -butyl} -5- (pyridin-3 -yl) -penta-2 , 4- dienεaureamide ,- N- {4- [4- (6, ll-dihydro-dibenzo [b, e] oxepin-11-yl) -piperazin-l- yl] -butyl -3 -pyridin-3 -yl-propionamide and N- {2- [4- (6, 11-dihydrodibenzo [b, e] thiepin-11-yl) -piperazin-l- yl] -ethyl} -3 -pyridin-3 -yl-acrylamide. N- [4- (4-diphenylacetyl-piperazin-l-yl) -butyl] -3-pyridin-3-yl- acrylamide; N- [4- (4-benzoylpiperazin-l-yl) -butyl] -3-pyridin-3-yl- acry1amide,- N- {4- [4- (2-aminobenzoyl) -piperazin-l-yl] -butyl} -3-pyridin-3- yl-acrylamide; N- {4- [4- (4-carboxybenzoyl) -piperazin-l-yl] -butyl} -3-pyridin- 3 -yl-acrylamide; „ . , N- {4- [4- (biphenyl -2 -carbonyl) -piperazin-l-yl] -butyl} -3- pyridin-3 -yl-acrylamide ; N- {4- [4- (9-oxo-9H-fluoren-4 -carbonyl) -piperazin-l-yl] -butyl} - 3 -pyridin-3 -yl-acrylamide and N- {4- [4- (furan-2 -carbonyl) -piperazin-l-yl] -butyl} -3-pyridin- 3 -yl -acrylamide. N- {4- [4- (naphthalin-1-yl-aminocarbonyl) -piperazin-l-yl] - butyl } - 3 -pyridin-3 -yl-propionamide ,- N- {4- [4- (diphenylaminocarbonyl) -piperazin-l-yl] -butyl} -3- pyridin-3 -yl-acrylamide,- N- {4- [4- (naphthalin-2-εulfonyl) -piperazin-l-yl] -butyl} -3- pyri-din-3-yl-acrylamide as well aε N- [4- (4 -diphenylphoεphinonyl -piperazin-l-yl) -butyl] -3- pyridin-3 -yl-acrylamide . N- [4- (4-biphenyl-2-yl-piperazin-l-yl) -butyl] -3 -pyridin-3 -yl- acrylamide ,- N-{4- [4- (9H-fluoren-9-yl) -piperazin-l-yl] -butyl} -3-pyridin-3- yl-acrylamide and N-{4- [4- (10, ll-dihydro-5H-dibenzo[a,d] cyclohepten-5-yl) - piper-azin-1-yl] -butyl} -3 -pyridin-3 -yl-acrylamide . 8. Method for the production of compounds according to claims 1-7 according to formula (I) (A) Characterized in that carboxylic acids of formula (II) in which R 1 , R 2 , R 3 , A and k have the meaning given above or their reactive derivativeε, eεpecially their acid chlorideε or activated eεters, are reacted, optionally in the presence of condensation agents, with compounds of formula (III) -N— I R 4 (III) wherein D, E, G and R 4 are defined as in claim 1 in the form of the respective free baεe or the respective acid addition salt, preferably in one or more inert solventε, at a temperature between -40°C and 180°C optionally in the preεence of an auxiliary base or according to the method variant . (B) The compoundε according to the general formula (I) , according to the claims 1-7 are produced in the manner that compounds of the formula (I) , wherein G is hydrogen, are reacted as starting materials with a compound of formula (IV) (IV) in which G has the meaningε given in the claimε 1-7, with the exception of hydrogen, and L is a suitable nucleofuge or reactive group respectively, or according to method variant. (BI) Compoundε of formula (I) , in which G, with the exception of hydrogen, haε the meaning of G 1 according to the definition in claim 1 can alεo be produced, aεide from method (A) , by reacting compounds of formula (I) , in which G iε hydrogen, with a suitable alkylation agent and/or arylation agent of formula (IV), wherein G is an alkyl-, alkenyl-, alkinyl-, cycloalkyl-, aryl-, aralkyl-, heteroaryl- or heteroaralkyl residue according to definition and the leaving group L representε a reactive derivative of an alcohol, εuch aε a halogen atom εuch as chlorine, bromine or iodine or a sulfonic acid ester a methanesulfonyloxy group, trifluoromethaneεulfonyloxy- , ethaneεulfonyloxy- , benzene- εulfonyloxy- , p-tolueneεulfonyloxy- , p-bromobenzene- sulfonyloxy- , m-nitrobenzenesulfonyloxy group or a terminal epoxide group aε a reactive group, wherein thiε reaction occurε i a εuitable inert solvent at a temperature between 0°C and 180 °C, depending on the reactivity of the educt, or according to method variant. (B2) Compoundε of formula (I) , in which G repreεentε an acyl reεidue, a carbamoyl reεidue, a εulfonyl reεidue or a phosphinoyl residue according to the definition according to claim 1 produced in a manner by reacting compounds of formula (I) , wherein G has the meaning hydrogen, with a carboxylic acid, carbamic acid, sulfonic acid and/or phoεphinic acid of formula (V) , Ho ¬ rn wherein G iε an acyl reεidue, carbamoyl residue, sulfonyl reεidue or phosphinoyl reεidue according to definition, or their derivativeε capable of reaction, whereby the reaction of reactive derivativeε with compounds (I) , in which G iε hydrogen, preferably occurε in the preεence of auxiliary baεeε in εolventε and under conditions aε they are deεcribed in method (A) ,- or according to method variant . „, . 214 (B3 ) Compoundε of formula ( I ) , wherein G iε a carbamoyl reεidue according to the definition (G2b) with r = 0 in the form of the group — C-NR 13 R 15 O are produced in the manner of reacting compoundε of formula (I) , in which G is hydrogen, with a carbonyl group transmitter to an intermediate product and subεequently reacting thiε directly with a primary or secondary amine with the formula (VI) H-NR 13 R 15 (VI) M 13 R 15 wherein R 13 and R 15 and/or the grouping N *^ ^ have the meanings given in claim 1 or 2 without purifying or isolating the intermediate product, preferably compound (VI) iε added in a stochiometric amount or in excess as a solution or a εolid and the reaction iε completed, whereby the reaction temperatureε lie between -40°C and 50°C for the first partial reaction and between 0°C and 150°C for the second partial reaction, or according to method variant. (B4) Compounds of formula (I) , wherein G is a carbamoyl reεidue according to the definition (G2b) with r = 0 and R 15 = hydrogen, in the group are produced in a manner that compoundε of formula (I) according to claim 1 in which G iε hydrogen, are reacted with an iεocyanate of formula (VII) 13 O=C=N-R (VI I ) in which R 13 has the meaning given in claim 1, in an abεolute, inert εolvent at a temperature from -20°C to 150°C. 9. Compound or compound mixture according to one of claims 1 to 7 for uεe in a therapeutic method for treatment of the human or animal body or in a corresponding diagnosiε method. 10. Compound or compound mixture according to claim 9 for uεe in a therapeutic or diagnoεtic method, characterized in that the therapeutic uεe is in connection with cancerostatic or cytostatic or immunosuppreεsive treatment or abnormal cell growth and/or preventing the formation of metastaseε and/or proliferation, optionally in connection with εuitable pharmaceutically acceptable adjuvantε and carrierε and/or one or more further active ingredients . 11. Use of one or more compounds according to one of claims 1 to 7 for the production of a medicament for the treatment of the human or animal body in the medical indications named above in claim 10 including all compounds which are excluded according to definition in claim 1 and 2. 12. Medicament with an amount of 1 or more active ingredients according to claim 1 to 7 optionally in connection with a pharmaceutically acceptable carrier, next to toxicologically safe adjuvants, optionally in combination with other active ingredients. 13. A method for the production of a medicament according to claim 12, characterized in that one or more compoundε according to one or more of claims 1 to 7 including all compoundε which are excluded according to definition in claim 1 and 2 and the reεpective claims dependent thereon are „ , , 216 processed to finished medical forms with suitable pharmacologically acceptable carriers and adjuvants. 14. Medicament according to claim 12, characterized in that it is present in a solid, peroral administrable form as a tablet, capsule, coated tablet, or as a liquid, peroral administrable solution, suspension, effervescent tablet, in the form of tabs or εachetε, optionally in εustained action, and/or in gastric fluid-resistant form. 15. Medicaments according to claim 12 or 14, characterized in that it is present in the form of a suitable injection or infusion preparation together with suitable pharmaceutically acceptable carriers and adjuvants, optionally in suεtained action form and or as a parenteral depot medicinal form or implant or is used in the form of a concentrate, powder or lyophilisate and the parenteral dilution agent iε optionally manufactured in the packaging separately therefrom, wherein the mixing of both compounds with each other or of the active ingredient with a common parenterally applicable dilution agent occurs immediately before use. 16. Medicament according to claim 12, characterized in that it is present in the form of an inhalation therapeutic agent, for example, in the form of a spray together with εuitable pharmaceutically acceptable propellantε, carrierε and adjuvantε . 17. Medicament according to claim 12, characterized in that it is preεent in the form of a tranεdermal therapeutic εyεtem for εystemic treatment . 18. Medicament according to claim 12, characterized in that it iε preεent in the form of a gastrointestinal therapeutic syεtem (GITS) for εyεtemic treatment. 19. Medicament according to claim 12, characterized in that it iε preεent in the form of a salve, suεpension, emulsion, a balm or plaεter or in the form of an externally applicable solution. 20. Medicament according to claim 16 for administration by means of a controlled dosage aerosol or in the form of a dry powder dosage formulation. 21. Medicament according to claim 12, characterized in that it is present in the form of a rectal, genital, or transurethral adminiεtration emulεion, a εolution, a liposomal solution, an implant, suppository or a capsule. 22. Medicament according to claim 12, characterized in that it is present in the form of a composition capable of being applied nasally, otologically or ophthalmologically . 23. Medicament according to one of the claims 12 or 14, characterized in that it is present in the form of a buccally applicable form. 24. Medicament according to one of the claims 12 and 14 to 16, characterized in that a dosage unit for single adminiεtration contains 0.001 or 0.01 to 2.0 mg or 0.1, 1, 2, 5, 10, 20, 25, 30, 50, 100, 200, 300, 500, 600, 800, 1000, 2000, 3000, 4000 or 5000 mg active ingredient according to the claimε 1 to 7, 9 and 10. 25. Medicament according to claim 16, characterized in that the pharmaceutically acceptable carrier and/or diluent is a propellant aerosol . 26. Medicament according to claim 16 or 25, characterized in that the propellant aerosol is tetrafluoroethane and/or heptafluoropropane and/or propane, butane, or dimethyl ether or mixtureε thereof . 27. Medicament according to one of the claims 16, 25 or 26, characterized in that the propellant aerosol contains εurface active adjuvantε. 28. Medicament according to one of the claims 12 or 16, characterized in that it containε glucoεe and/or lactoεe aε a dry powder doεage . 29. Subεtance or εubεtance mixture according to one of the claimε 9 or 10, characterized in that the therapeutic uεe occurs with a further cytoεtatic agent or immunoεuppressive agent . 30. Medicament according to one of the claims 12 and 14 to 28, characterized in that it is present in combination with a further cytoεtatic agent or immunoεuppreεεive agent, optionally in the form of εeparate doεage units in the pharmaceutical package. 31. Use of one or more compounds according to the general formula (I) according to claims 1 to 6 and according to claim 7 including compounds which are excluded according to definition in claims 1 and 2 for cytostatic and/or canceroεtatic or immunomodulatory and/or immunoεuppreεεive treatment, optionally in combination with a further cytoεtatic agent or immunoεuppressive agent and/or further medicaments suitable for theεe indicationε .

Inventors: BIEDERMANN ELFI, HASMANN MAX, LOESER ROLAND, RATTEL BENNO, REITER FRIEDEMANN, SCHEIN BARBARA, SEIBEL KLAUS, VOGT KLAUS, WOSIKOWSKI KATJA, BIEDERMANN, ELFI, HASMANN, MAX, LOESER, ROLAND, RATTEL, BENNO, REITER, FRIEDEMANN, SCHEIN, BARBARA, SEIBEL, KLAUS, VOGT, KLAUS, WOSIKOWSKI, KATJA
Applicants: BIEDERMANN ELFI, HASMANN MAX, KLINGE CO CHEM PHARM FAB, LOESER ROLAND, RATTEL BENNO, REITER FRIEDEMANN, SCHEIN BARBARA, SEIBEL KLAUS, VOGT KLAUS, WOSIKOWSKI KATJA, BIEDERMANN, ELFI, HASMANN, MAX, KLINGE PHARMA GMBH, LOESER, ROLAND, RATTEL, BENNO, REITER, FRIEDEMANN, SCHEIN, BARBARA, SEIBEL, KLAUS, VOGT, KLAUS, WOSIKOWSKI, KATJA
Application year: 1998
Main classification: C07D213
IPC codes: A61K31, A61P35, A61P37, A61P43, C07D213, C07D401, C07D405, C07D409, C07D417, C07D487, C07D491, C07D495, C07D513, C07F9