OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS

Abstract: The invention relates to compounds of formula (I) [wherein: ring Z is, for example, a 6-membered aromatic heterocyclic ring containing 1 or 2 nitrogen atoms; R<1> represents hydrogen, C1-4alkyl, C1-4alkoxymethyl, di(C1-4alkoxy)methyl or C1-4alkanoyl; R<2> represents, for example, halogeno, trifluoromethyl, 2,2,2-trifluoroethyl, cyano, nitro, C1-3alkylsulphonyl, carbamoyl, <u>N</u>-C1-3alkylcarbamoyl, <u>N</u>,<u>N</u>-di(C1-3alkyl)carbamoyl, aminosulphonyl, <u>N</u>-C1-3alkylaminosulphonyl or <u>N</u>,<u>N</u>-di(C1-3alkyl)aminosulphonyl; n is an integer from 0 to 3; m is an integer from 0 to 4; and R<3> represents, for example, hydroxy, halogeno, nitro, trifluoromethyl, C1-3alkyl, cyano, amino or R<15>X<7> (wherein R<15> is, for example, an optionally substituted 5-6-membered carbocyclic or heterocyclic group or a group which is alkenyl, alkynyl or optionally substituted alkyl, which alkyl group may contain a heteroatom linking group, which alkenyl, alkynyl or alkyl group may carry a terminal optionally substituted group selected from alkyl and a 5-6-membered carbocyclic or heterocyclic group and X<7> is a linker group such as -O- or -NR-)] and salts thereof, processes for their preparation and pharmaceutical compositions containing them as active ingredient. The compounds of formula (I) and salts thereof inhibit the effects of VEGF and FGF, properties of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.

Description: OXINDOLY QUINAZOLINE DERIVATIVES AS ANGIOGENES IS INHIBITORS The present invention relates to heteroaromatic oxindole derivatives, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of disease states associated with angiogenesis and/or increased vascular permeability, to their use as medicaments and to their use in the manufacture of medicaments for use in the production of antiangiogenic and/or vascular permeability reducing effects in warm-blooded animals such as humans. Normal angiogenesis plays an important role in a variety of processes including embryonic development, wound healing and several components of female reproductive function. Undesirable or pathological angiogenesis has been associated with disease states including diabetic retinopathy, psoriasis, cancer, rheumatoid arthritis, atheroma, Kaposi's sarcoma and haemangioma (Fan et al, 1995, Trends Pharmacol. Sci. 16: 57-66; Folkman, 1995, Nature Medicine 1: 27-31). Alteration of vascular permeability is thought to play a role in both normal and pathological physiological processes (Cullinan-Bove et al, 1993, Endocrinology 133: 829-837; Senger et al, 1993, Cancer and Metastasis Reviews, 12: 303- 324). Several polypeptides with in vitro endothelial cell growth promoting activity have been identified including, acidic and basic fibroblast growth factors (aFGF & bFGF) and vascular endothelial growth factor (VEGF). By virtue of the restricted expression of its receptors, the growth factor activity of VEGF, in contrast to that of the FGFs, is relatively specific towards endothelial cells. Recent evidence indicates that VEGF is an important stimulator of both normal and pathological angiogenesis (Jakeman et al, 1993, Endocrinology, 133: 848-859; Kolch et al, 1995, Breast Cancer Research and Treatment, 36: 139-155) and vascular permeability (Connolly et al, 1989, J. Biol. Chem. 264: 20017-20024). Antagonism of VEGF action by sequestration of VEGF with antibody can result in inhibition of tumour growth (Kim et al, 1993, Nature 362: 841-844). Basic FGF (bFGF) is a potent stimulator of angiogenesis (e.g. Hayek et al, 1987, Biochem. Biophys. Res. Commun. 147: 876-880) and raised levels of FGFs have been found in the serum (Fujimoto et al, 1991, Biochem. Biophys. Res. Commun. 180: 386-392) and urine (Nguyen et al, 1993, J. Natl. Cancer. Inst. 85: 241-242) of patients with cancer. Receptor tyrosine kinases (RTKs) are important in the transmission of biochemical signals across the plasma membrane of cells. These transmembrane molecules characteristically consist of an extracellular ligand-binding domain connected through a segment in the plasma membrane to an intracellular tyrosine kinase domain. Binding of ligand to the receptor results in stimulation of the receptor-associated tyrosine kinase activity which leads to phosphorylation of tyrosine residues on both the receptor and other intracellular molecules. These changes in tyrosine phosphorylation initiate a signalling cascade leading to a variety of cellular responses. To date, at least nineteen distinct RTK subfamilies, defined by amino acid sequence homology, have been identified. One of these subfamilies is presently comprised by the fms-like tyrosine kinase receptor, Fit or Fltl, the kinase insert domain-containing receptor, KDR (also referred to as Flk-1), and another fms-like tyrosine kinase receptor, Flt4. Two of these related RTKs, Fit and KDR, have been shown to bind VEGF with high affinity (De Vries et al, 1992, Science 255: 989-991; Terman et al, 1992, Biochem. Biophys. Res. Comm. 1992, 187: 1579-1586). Binding of VEGF to these receptors expressed in heterologous cells has been associated with changes in the tyrosine phosphorylation status of cellular proteins and calcium fluxes. The present invention is based on the discovery of compounds that surprisingly inhibit the effects of VEGF and FGF, properties of value in the treatment of disease states associated with angiogenesis and/or increased vascular permeability such as cancer, diabetes, psoriasis, rheumatoid arthritis, Kaposi's sarcoma, haemangioma, acute and chronic nephropathies, atheroma, arterial restenosis, autoimmune diseases, acute inflammation and ocular diseases with retinal vessel proliferation. Compounds of the present invention possess higher potency against VEGF receptor tyrosine kinase and against FGF Rl receptor tyrosine kinase than against epidermal growth factor (EGF) receptor tyrosine kinase. Furthermore, compounds of the present invention, possess substantially higher potency against VEGF receptor tyrosine kinase and against FGF Rl receptor tyrosine kinase than against EGF receptor tyrosine kinase. Compounds of the invention which have been tested possess activity against VEGF receptor tyrosine kinase and against FGF Rl receptor tyrosine kinase such that they may be used in an amount sufficient to inhibit VEGF receptor tyrosine kinase and FGF Rl receptor tyrosine kinase whilst demonstrating no significant activity against EGF receptor tyrosine kinase. Thus compounds of the present invention possess good VEGF receptor tyrosine kinase activity and good FGF Rl receptor tyrosine kinase activity. Compounds with both VEGF receptor tyrosine kinase activity and FGF Rl receptor tyrosine kinase activity are believed to be of particular value in the treatment of disease states associated with angiogenesis and or increased vascular permeability. According to one aspect of the present invention there are provided compounds of the formula I: (I) [wherein: ring Z is a 5 or 6-membered heterocyclic ring containing 1 to 3 heteroatoms selected independently from O, N and S with the proviso that the group at the 4-position of the quinazoline ring is not a substituted or unsubstituted group selected from 4,5,7-triazaoxindol- 3-yl and 4,6,7-triazaoxindol-3-yl; R 1 represents hydrogen, Cι -4 alkyl, C 1-4 alkoxymethyl, di(Cι- alkoxy)methyl or Cι -4 alkanoyl; R 2 represents hydroxy, halogeno, C1.3a.kyl, Cι -3 alkoxy, Cι -3 alkanoyloxy, trifluoromethyl, 2,2,2-trifluoroethyl, cyano, amino, nitro, C 2- alkanoyl, Cι- alkanoylamino, . 4 alkoxycarbonyl, Cι -4 alkylthio, Cι -4 alkylsulphinyl, Cι -4 alkylsulphonyl, carbamoyl, N-Ci. 4alkylcarbamoyl, N,N-di(Cι -4 alkyl)carbamoyl, aminosulphonyl, N-Cι- alkylaminosulphonyl, N,N-di(Cι -4 alkyl)aminosulphonyl or Cι -4 alkylsulphonylamino or R 2 is selected from one of the following four groups: 1) R 4 X l wherein X 1 represents a direct bond, -O-, -NR 5 -, Cι -3 alkyl, C 2-4 alkanoyl, -CONR 6 R 7 -, -SO 2 NR 8 R 9 - or -SO 2 R 10 - (wherein R 5 , R 6 and R 8 , each independently represents hydrogen or C (-2 alkyl and R 7 , R 9 and R 10 each independently represents C 1-4 alkyl and wherein R 4 is linked to R 7 , R 9 or R 10 ) and R 4 represents phenyl or a 5 or 6-membered heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group may be saturated or unsaturated and which phenyl or heterocyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, Cι -3 alkyl, Cι -3 alkoxy, Cι -3 alkanoyloxy, trifluoromethyl, cyano, amino, nitro and 2) X 2 C 2-4 alkylX 3 Cι -3 alkyl (wherein X 2 is -O- or -NR 11 - (wherein R u is hydrogen, d. 3 alkyl or Cι -3 alkoxyC 2-3 alkyl) and X 3 is -O-, -NR 12 -, -S-, -SO- or -SO 2 - (wherein R 12 is hydrogen, Q. 3 alkyl or C 1-3 alkoxyC 2-3 alkyl); 3) Cι -2 alkylX 4 C 2-3 alkylX 5 Cι -3 alkyl (wherein X 4 and X 5 which may be the same or different are each -O-, -S-, -SO-, -SO 2 - or -NR 13 - (wherein R 13 is hydrogen, C 1-3 alkyl or Cι -3 alkoxyC 2 . 3 alkyl); and 4) Cι -3 alkylX 6 Cι -3 alkyl (wherein X 6 is -O-, -S-, -SO-, -SO 2 - or -NR 14 - (wherein R 14 is hydrogen, Cι -3 alkyl or Cι -3 alkoxyC 2-3 alkyl); n is an integer from 0 to 3 when Z is a 6-membered heterocyclic ring and n is an integer from 0 to 2 when Z is a 5-membered heterocyclic ring; m is an integer from 0 to 4; and R 3 represents hydroxy, halogeno, nitro, trifluoromethyl, Cι -3 alkyl, cyano, amino or R 15 X 7 (wherein X 7 represents a direct bond, -O-, -CH 2 -, -S-, -SO-, -SO 2 -, -NR 16 CO-, -CONR 17 -, - SO 2 NR 18 -, -NR 19 SO 2 - or -NR 20 - (wherein R 16 , R 17 , R 18 , R 19 and R 20 each independently represents hydrogen, C 1-3 alkyl or Cι -3 alkoxyC 2- 3alkyl), and R 15 is selected from one of the following seventeen groups: 1) hydrogen or Q.salkyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy, fluoro and amino; 2) Cι -5 alkylX 8 COR 21 (wherein X 8 represents -O- or -NR 22 - (in which R 22 represents hydrogen, Cι -3 alkyl or Cι -3 alkoxyC 2-3 alkyl) and R 21 represents d -3 alkyl, -NR 23 R 24 - or -OR 25 - (wherein R 23 , R 24 and R 25 which may be the same or different each represents hydrogen, Cι -3 alkyl or C \ . 3 alkoxyC 2-3 alkyl)); 3) C, -5 alkylX 9 R 26 (wherein X 9 represents -O-, -S-, -SO-, -SO 2 -, -OCO-, -NR 27 CO-, -CONR 28 -, -SO 2 NR 29 -, -NR 30 SO 2 - or -NR 31 - (wherein R 27 , R 28 , R 29 , R 30 and R 31 each independently represents hydrogen, Cι -3 alkyl or Cι.3alkoxyC 2- 3alkyl) and R 26 represents hydrogen, Cι -3 alkyl, cyclopentyl, cyclohexyl or a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which Cι -3 alkyl group may bear one or two substituents selected from oxo, hydroxy, halogeno and Cι -4 alkoxy and which cyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, Cι -4 alkyl, C \ . 4 hydroxy alkyl and Cι -4 alkoxy); 4) Cι. 5 alkylX 10 Cι. 5 alkylX u R 32 (wherein X 10 and X 11 which may be the same or different are each -O-, -S-, -SO-, -SO 2 -, -NR 33 CO-, -CONR 34 -, -SO 2 NR 35 -, -NR 36 SO 2 - or -NR 37 - (wherein R 33 , R 34 , R 35 , R 36 and R 37 each independently represents hydrogen, Cι. 3 alkyl or Cι -3 alkoxyC 2- 3 alkyl) and R 32 represents hydrogen or Cι -3 alkyl); 5) R 38 (wherein R 38 is a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, C 1- alkyl, ^hydroxy alkyl and Ci. 4 alkoxy); 6) Ci.salkylR 38 (wherein R 38 is as defined hereinbefore); 7) C 2 - 5 alkenylR 38 (wherein R 38 is as defined hereinbefore); 8) C 2- salkynylR 38 (wherein R 38 is as defined hereinbefore); 9) R 39 (wherein R 39 represents a pyridone group, a phenyl group or a 5 or 6-membered aromatic heterocyclic group with 1 to 3 heteroatoms selected from O, N and S, which pyridone, phenyl or heterocyclic group may carry up to 5 substituents selected from hydroxy halogeno, amino, Cι. 4 alkyl, Cι. 4 alkoxy, Q. 4 hydroxyalkoxy, carboxy, trifluoromethyl, cyano, -CONR 40 R 41 and -NR 42 COR 43 - (wherein R 40 , R 41 , R 42 and R 43 , which may be the same or different, each represents hydrogen, Cι -4 alkyl or Cι. 3 alkoxyC 2 - 3 alkyl)); 10) Cι -5 alkylR 39 (wherein R 39 is as defined hereinbefore); 11) C 2-5 alkenylR 39 (wherein R 39 is as defined hereinbefore); 12) C 2 .salkynylR 39 (wherein R 39 is as defined hereinbefore); 13) C, -5 alkylX 12 R 39 (wherein X 12 represents -O-, -S-, -SO-, -SO 2 -, -NR^CO-, -CONR 45 -, - SO 2 NR 46 -, -NR 47 SO 2 - or -NR 48 - (wherein R 44 , R 45 , R 46 , R 47 and R 48 each independently represents hydrogen, or Cι-3alkoxyC 2-3 alkyl) and R 39 is as defined hereinbefore); 14) C 2-5 alkenylX 13 R 39 (wherein X 13 represents -O-, -S-, -SO-, -SO 2 -, -NR 49 CO-, -CONR 50 -, - SO 2 NR 51 -, -NR 52 SO 2 - or -NR 53 - (wherein R 49 , R 50 , R 51 , R 52 and R 53 each independently represents hydrogen, Cι -3 alkyl or Cι-3alkoxyC 2- 3alkyl) and R 39 is as defined hereinbefore); 15) C 2-5 alkynylX 14 R 39 (wherein X 14 represents -O-, -S-, -SO-, -SO 2 -, -NR 54 CO-, -CONR 55 -, - SO 2 NR 56 -, -NR 57 SO 2 - or -NR 58 - (wherein R 54 , R 55 , R 56 , R 57 and R 58 each independently represents hydrogen, C| -3 alkyl or C|. 3 alkoxyC 2- 3alkyl) and R 39 is as defined hereinbefore); 16) C I-3 alkylX l5 C, -3 alkylR 39 (wherein X 15 represents -O-, -S-, -SO-, -SO 2 -, -NR 59 CO-, - CONR 60 -, -SO 2 NR 61 -, -NR 62 SO 2 - or -NR 63 - (wherein R 59 , R 60 , R 61 , R 62 and R 63 each independently represents hydrogen, Cι. 3 alkyl or Cι- 3 alkoxyC 2-3 alkyl) and R 39 is as defined hereinbefore); and 17) Cι -3 alkylX 15 C,. 3 alkylR 38 (wherein X 15 and R 38 are as defined hereinbefore))]; and salts thereof. According to another aspect of the present invention there are provided compounds of the formula I wherein: R 1 , R 2 , R 3 , m and n are as defined hereinbefore; and ring Z is a 6-membered heterocyclic ring containing 1 to 3 nitrogen atoms with the proviso that the group at the 4-position of the quinazoline ring is not a substituted or unsubstituted group selected from 4,5,7-triazaoxindol-3-yl and 4,6,7-triazaoxindol-3-yl; and salts thereof. According to another aspect of the present invention there are provided compounds of the formula I wherein: R 1 , R 2 , R 3 , m and n are as defined hereinbefore; and ring Z is a 6-membered heterocyclic ring containing 1 or 2 nitrogen atoms; with the proviso that where R 2 is a group R 4 X\ X 1 is not C 2- alkanoyl or -SO 2 R 10 - and R 4 is not optionally substituted phenyl or an optionally substituted 5or 6-membered unsaturated heterocyclic ring; and salts thereof. Advantageously ring Z is a 6-membered aromatic heterocyclic ring containing 1 to 3 nitrogen atoms with the proviso that the group at the 4-position of the quinazoline ring is not a substituted or unsubstituted group selected from 4,5,7-triazaoxindol-3-yl and 4,6,7- triazaoxindol-3-yl, or Z is a 5-membered aromatic heterocyclic ring containing 1 to 3 heteroatoms selected independently from O, N and S. Preferably Z is a 6-membered aromatic heterocyclic ring containing 1 to 3 nitrogen atoms with the proviso that the group at the 4-position of the quinazoline ring is not a substituted or unsubstituted group selected from 4,5,7-triazaoxindol-3-yl and 4,6,7 -triazaoxindol-3-yl. More preferably Z is a 6-membered aromatic heterocyclic ring containing 1 or 2 nitrogen atoms. In a particular aspect of the present invention Z is a 6-membered aromatic heterocyclic ring containing 1 or 2 nitrogen atoms such that the substituent at the 4-position of the quinazoline ring is selected from the groups 7-azaoxindol-3-yl and 5,7-diazaoxindol-3-yl, which group bears (R 2 ) n as defined hereinbefore. Conveniently R 2 represents hydroxy, halogeno, C 1 3 alkyl, Cι -2 alkoxy, trifluoromethyl, 2,2,2- trifluoroethyl, cyano, nitro, C 2-3 alkanoyl, Cι -3 alkanoylamino, Cι -3 alkoxycarbonyl, Q. 3 alkylthio, Cι -3 alkylsulphinyl, Cι. 3 alkylsulphonyl, carbamoyl, N-Cι -3 alkylcarbamoyl, N,N- di(Cι -3 alkyl)carbamoyl, aminosulphonyl, N-Cι -3 alkylaminosulphonyl, N,N-di(Cι. 3 alkyl)aminosulphonyl or C 1-3 alkylsulphonylamino or R 2 is selected from one of the following four groups: 1) R 4 X [ wherein X 1 represents -O-, -NR 5 -, Cι -3 alkyl, -CONR 6 R 7 - or -SO 2 NR 8 R 9 - (wherein R 5 , R 6 and R 8 , each independently represents hydrogen or Cι -2 alkyl and R 7 and R 9 each independently represents Cι -3 alkyl and wherein R 4 is linked to R 7 or R 9 ) and R 4 represents a 5 or 6-membered heterocyclic group with one or two heteroatoms, selected independently from O, S, and N, which heterocyclic group may be saturated or unsaturated and which heterocyclic group may bear one or two substituents selected from hydroxy, halogeno, Cι -3 alkyl, Q. 3 alkoxy, Cι -3 alkanoyloxy, trifluoromethyl, cyano, amino, nitro and Cι. 4 alkoxycarbonyl and which heterocyclic group may bear one or two oxo substituents on a ring nitrogen or ring sulphur heteroatom; 2) X 2 C 2-4 alkylX 3 C I-3 alkyl (wherein X 2 is -O- or -NR 11 - (wherein R π is hydrogen, C,. 2 alkyl or Cι -2 alkoxyethyl) and X 3 is -O-, -NR 12 - or -SO 2 - (wherein R 12 is hydrogen, d -2 alkyl or Ci. 2 alkoxyethyl); 3) C| -2 alkylX C 2-3 alkylX 5 Cι -3 alkyl (wherein X 4 and X 5 which may be the same or different are each -O-, -NR 13 - or -SO 2 - (wherein R 13 is hydrogen, Cι -2 alkyl or Cι -2 alkoxyethyl); and 4) C, -3 alkylX 6 Cι. 3 alkyl (wherein X 6 is -O-, -NR 14 - or -SO 2 - (wherein R 14 is hydrogen, C (- 2 alkyl or Cι -2 alkoxyethyl). Advantageously R 2 represents hydroxy, halogeno, Cι -3 alkyl, Cι -2 alkoxy, trifluoromethyl, 2,2,2-trifluoroethyl, cyano, nitro, C 2-3 alkanoyl, Cι -3 alkanoylamino, Cι -3 alkoxycarbonyl, Q. 3 alkylthio, Cι -3 alkylsulphinyl, Cι. 3 alkylsulphonyl, carbamoyl, N-C|. 3 alkylcarbamoyl, N,N- di(Cι. 3 alkyl)carbamoyl, aminosulphonyl, N-Ci^alkylaminosulphonyl, N,N-di(Cι_ 3 alkyl)aminosulphonyl or Cι -3 alkylsulphonylamino or R 2 is selected from one of the following four groups: 1) R 4 X' wherein X 1 represents -O-, -NR 5 -, C, -3 alkyl, -CONR 6 R 7 - or -SO 2 NR 8 R 9 - (wherein R 5 , R 6 and R 8 , each independently represents hydrogen or C . ι. 2 alkyl and R 7 and R 9 each independently represents Cι. 3 alkyl and wherein R 4 is linked to R 7 or R 9 ) and R 4 represents a 5 or 6-membered heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group may be saturated or unsaturated and which heterocyclic group may bear two oxo substituents on a ring sulphur heteroatom; 2) X 2 C 2 . 4 alkylX 3 Cι -3 alkyl (wherein X 2 is -O- or -NR 1 '- (wherein R 11 is hydrogen or C 1-2 alkyl) and X 3 is -O-, -NR 12 - or -SO 2 - (wherein R 12 is hydrogen or Cι -2 alkyl); 3) Cι -2 alkylX 4 C 2-3 alkyLX 5 Cι -3 alkyl (wherein X 4 and X 5 which may be the same or different are each -NR 13 - or -SO 2 - (wherein R 13 is hydrogen or Cι -2 alkyl); and 4) C, -3 alkylX 6 Cι -3 alkyl (wherein X 6 is -O-, -NR 14 - or -SO 2 - (wherein R 14 is hydrogen or C,. 2 alkyl). Preferably R 2 represents halogeno, Cι -3 alkyl, C 1-2 alkoxy, trifluoromethyl, 2,2,2-trifluoroethyl, cyano, nitro, Cι -3 alkanoylamino, Cι -3 alkylsulphonyl, carbamoyl, N-Cι -3 alkylcarbamoyl, N,N- di(Cι -3 alkyl)carbamoyl, aminosulphonyl, N-Cι -3 alkylaminosulphonyl, N,N-di(Cι- 3 alkyl)aminosulphonyl or Cι -3 alkylsulphonylamino or R 2 is selected from one of the following four groups: 1) R 4 X' wherein X 1 represents -O-, -NR 5 -, C,. 3 alkyl, -CONR 6 R 7 - or -SO 2 NR 8 R 9 - (wherein R 5 , R 6 and R 8 , each independently represents hydrogen or Cι -2 alkyl and R 7 and R 9 each independently represents Cj -3 alkyl and wherein R 4 is linked to R 7 or R 9 ) and R 4 represents a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O ,S and N, which heterocyclic group may bear two oxo substituents on a ring sulphur heteroatom; 2) X C 2-4 alkylX 3 C, -3 alkyl (wherein X 2 is -O- or -NR 11 - (wherein R 11 is hydrogen or Cι -2 alkyl) and X 3 is -O-, -NR 12 - or -SO 2 - (wherein R 12 is hydrogen or d -2 alkyl); 3) Cι -2 alkylX 4 C 2-3 alkylX 5 Cι -3 alkyl (wherein X 4 and X 5 which may be the same or different are each -NR 13 - or -SO 2 - (wherein R 13 is hydrogen or Cι -2 alkyl); and 4) Cι -3 alkylX 6 Cι -3 alkyl (wherein X 6 is -O-, -NR 14 - or -SO 2 - (wherein R 14 is hydrogen or Ci. 2 alkyl). More preferably R 2 represents halogeno, Cι -2 alkyl, Cι -2 alkoxy, trifluoromethyl, 2,2,2- trifluoroethyl, cyano, nitro, Cι -3 alkanoylamino, Cι -3 alkylsulphonyl, carbamoyl, N-Ci. 3 alkylcarbamoyl, N,N-di(Cι -3 alkyl)carbamoyl, aminosulphonyl, N-Cι -3 alkylaminosulphonyl, N,N-di(Cι -3 alkyl)aminosulphonyl or Cι-3alkylsulphonylamino or R 2 is selected from one of the following four groups: 1) R 4 X r wherein X 1 represents -O-, -NR 5 -, Cι. 3 alkyl, -CONR 6 R 7 - or -SO 2 NR 8 R 9 - (wherein R 5 , R 6 , and R 8 , each independently represents hydrogen or Cι -2 alkyl and R 7 and R 9 each independently represents Cι -3 alkyl and wherein R 4 is linked to R 7 or R 9 ) and R 4 represents a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group may bear two oxo substituents on a ring sulphur heteroatom; 2) X 2 C 2-3 alkylX 3 methyl (wherein X 2 is -O- or -NR 11 - (wherein R 11 is hydrogen or Cι -2 alkyl) and X 3 is -O-, -NR 12 - or -SO 2 - (wherein R 12 is hydrogen or d -2 alkyl); 3) Cι -2 alkylX 4 C 2-3 alkylX 5 methyl (wherein X 4 and X 5 which may be the same or different are each -NR 13 - or -SO 2 - (wherein R 13 is hydrogen or Cι -2 alkyl); and 4) Cι- alkylX 6 Cι -2 alkyl (wherein X 6 is -O-, -NR 14 - or -SO 2 - (wherein R 14 is hydrogen or C,_ 2 alkyl). Especially R 2 represents halogeno, Cι -2 alkyl, Cι -2 alkoxy, trifluoromethyl, 2,2,2-trifluoroethyl, cyano, nitro, Cι. 3 alkanoylamino, Cι. 3 alkylsulphonyl, carbamoyl, N-Cι -3 alkylcarbamoyl, N,N- di(Cι -3 alkyl)carbamoyl, aminosulphonyl, N-Cι -3 alkylaminosulphonyl, N,N-di(d. 3 alkyl)aminosulphonyl or Cι. 3 alkylsulphonylamino. More especially R 2 represents halogeno, trifluoromethyl, 2,2,2-trifluoroethyl, cyano, nitro, d. 3 alkylsulphonyl, carbamoyl, N-Cι -3 alkylcarbamoyl, N,N-di(Cι -3 alkyl)carbamoyl, aminosulphonyl, N-Cι -3 alkylaminosulphonyl or N,N-di(Cι -3 alkyl)aminosulphonyl. In a particular aspect of the present invention when Z is a 6-membered aromatic heterocyclic ring containing 1 to 3 nitrogen atoms, with the proviso that the group at the 4-position of the quinazoline ring is not a substituted or unsubstituted group selected from 4,5,7-triazaoxindol- 3-yl and 4,6,7-triazaoxindol-3-yl, R 2 is not attached at the 4-position of the heteroaromatic oxindole ring unless R 2 is fluoro. In a further particular aspect of the present invention when Z is a 6-membered aromatic heterocyclic ring containing 1 to 3 nitrogen atoms, with the proviso that the group at the 4- position of the quinazoline ring is not a substituted or unsubstituted group selected from 4,5,7- triazaoxindol-3-yl and 4,6,7-triazaoxindol-3-yl, R 2 is attached at the 5- and/or 6-positions of the heteroaromatic oxindole ring, but if R 2 is fluoro it can be attached at the 4-, 5-, 6- or 7- position(s) of the heteroaromatic oxindole ring. In another particular aspect of the present invention when Z is a 6-membered aromatic heterocyclic ring containing 1 or 2 nitrogen atoms R 2 is attached at the 5- and/or 6-positions of the heteroaromatic oxindole ring, but if R 2 is fluoro it can be attached at the 4-, 5-, 6- or 7- position(s) of the heteroaromatic oxindole ring. Preferably n is an integer from 0 to 2. Preferably R 1 represents hydrogen, Cι- 4 alkoxymethyl, di(Cι -4 alkoxy)methyl or Cι. 4 alkanoyl, especially hydrogen. Preferably m is an integer from 0 to 2, most preferably 1 to 2. Advantageously X 7 represents -O-, -S-, -NR 16 CO-, -NR 19 SO 2 - or -NR 20 - (wherein R 16 , R 19 and R 20 each independently represents hydrogen, Cι -2 alkyl or Cι -2 alkoxyethyl). Preferably X 7 represents -O-, -S-, -NR ,6 CO-, -NR 19 SO 2 - (wherein R 16 and R 19 each independently represents hydrogen or or NH. More preferably X 7 represents -O-, -S-, -NR 16 CO- (wherein R 16 represents hydrogen or d. 2 alkyl) or NH. Particularly X 7 represents -O- or -NR 16 CO- (wherein R 16 represents hydrogen or more particularly -O- or -NHCO-, especially -O-. Advantageously X 8 represents -O- or -NR 22 - (wherein R 22 represents hydrogen, Cι -3 alkyl or Advantageously X 9 represents -O-, -S-, -SO-, -SO 2 -, -NR 27 CO-, -NR 30 SO 2 - or -NR 31 - (wherein R 27 , R 30 and R 31 each independently represents hydrogen, Cι -2 alkyl or Ci. 2 alkoxy ethyl). Preferably X 9 represents -O-, -S-, -SO-, -SO 2 - or -NR 31 - (wherein R 31 represents hydrogen, Cι_ 2 alkyl or More preferably X 9 represents -O-, -SO2- or -NR 31 - (wherein R 31 represents hydrogen or d. 2 alkyl). Advantageously X 10 and X 1 ' which may be the same or different each represents -O-, -S-, - SO-, -SO 2 - or -NR 37 - (wherein R 37 represents hydrogen, Cι -3 alkyl or d. 2 alkoxyethyl). Preferably X 10 and X 11 which may be the same or different each represents -O-, -S-, -SO 2 - or - NR 37 - (wherein R 37 represents hydrogen, Cι -2 alkyl or Cι -2 alkoxyethyl). More preferably X 10 and X 11 which may be the same or different each represents -O-, -SO 2 - or -NH-. Advantageously X 12 represents -O-, -S-, -SO 2 - or -NR 48 - (wherein R 48 represents hydrogen, or Ci. ∑ alkoxy ethyl). Preferably X 12 represents -O-, -SO 2 - or -NR 48 - (wherein R 48 represents hydrogen or d_ 2 alkyl). Advantageously X 13 represents -O-, -S-, -SO 2 - or -NR 53 - (wherein R 53 represents hydrogen, Cι. 2 alkyl or Cι -2 alkoxyethyl). Preferably X 13 represents -O-, -SO 2 - or -NR 53 - (wherein R 53 represents hydrogen or d -2 alkyl). Advantageously X 14 represents -O-, -S-, -SO 2 - or -NR 58 - (wherein R 58 represents hydrogen, Preferably X 14 represents -O-, -SO 2 - or -NR 58 - (wherein R 58 represents hydrogen or Advantageously X 15 represents -O-, -S-, -SO 2 - or -NR 63 - (wherein R 63 represents hydrogen, Cι. 2 alkyl or Cι -2 alkoxyethyl). Preferably X 15 represents -O-, -SO 2 - or -NR 63 - (wherein R 63 represents hydrogen or Cι -2 alkyl). R 38 is preferably pyrrolidinyl, piperazinyl, piperidinyl, morpholino or thiomorpholino which group may carry one or two substituents selected from oxo, hydroxy, halogeno, Cι -2 alkyl, Ci. 2 hydroxy alkyl and More preferably R 38 is pyrrolidinyl, piperazinyl, piperidinyl, morpholino, thiomorpholino, 1- methylpiperazinyl or 1-ethylpiperazinyl which group may carry one or two oxo substituents. R 39 preferably represents a pyridone group or a 5 or 6-membered aromatic heterocyclic group with 1 to 3 heteroatoms selected from O, N and S, which pyridone group or heterocyclic group may be substituted as hereinbefore defined. Where R 39 is a 5 or 6-membered aromatic heterocyclic group, it preferably has 1 or 2 heteroatoms, selected from O, N and S, of which more preferably one is N, and may be substituted as hereinbefore defined. R 39 is particularly a pyridone, pyridyl, imidazolyl, thiazolyl, thienyl, triazolyl, pyridazinyl, pyrazinyl or pyrimidinyl group which group may be substituted as hereinbefore defined, more particularly a pyridone, pyridyl, imidazolyl, thiazolyl or triazolyl group, especially a pyridone, pyridyl, imidazolyl or triazolyl group which group may be substituted as hereinbefore defined. In one embodiment of the invention R 39 represents a pyridone, phenyl or 5 or 6-membered aromatic heterocyclic group with 1 to 3 heteroatoms selected from O, N and S, which group may preferably carry up to 2 substituents, more preferably up to one substituent, selected from the group of substituents as hereinbefore defined. In the definition of R 39 , conveniently substituents are selected from halogeno, C| -4 alkyl, Ci. 4 alkoxy, trifluoromethyl and cyano, more conveniently substituents are selected from chloro, fluoro, methyl, ethyl and trifluoromethyl. Conveniently R 3 represents hydroxy, halogeno, nitro, trifluoromethyl, Cι -3 alkyl, cyano, amino or R I5 X 7 [wherein X 7 is as hereinbefore defined and R 15 is selected from one of the following seventeen groups: 1) Ci.salkyl which may be unsubstituted or substituted with one or more fluorine atoms, or C 2 - salkyl which may be unsubstituted or substituted with one or more groups selected from hydroxy and amino; 2) C 2-3 alkylX 8 COR 21 (wherein X 8 is as hereinbefore defined and R 21 represents Cι -3 alkyl, - NR 23 R 24 _ or _OR 25 - (wherein R 23 , R 24 and R 25 which may be the same or different are each . 2 alkyl or Cι -2 alkoxyethyl)); 3) C 2-4 alkylX 9 R 26 (wherein X 9 is as hereinbefore defined and R 26 represents hydrogen, Ci. 3 alkyl, cyclopentyl, cyclohexyl or a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which Cι -3 alkyl group may bear one or two substituents selected from oxo, hydroxy, halogeno and Cι -3 alkoxy and which cyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, Cι. 4 alkyl, Ci- 4 hy droxy alky 1 and C i - alkoxy ) ; 4) C 2-3 alkylX 10 C 2-3 alkylX π R 32 (wherein X 10 and X 11 are as hereinbefore defined and R 32 represents hydrogen or d -3 alkyl); 5) R 38 (wherein R 38 is as defined hereinbefore); 6) Cι- alkylR 64 (wherein R 64 is a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group is linked to Cι- alkyl through a carbon atom and which heterocyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, d- hydroxyalkyl and Cι_ 4 alkoxy) or d-salkylR 65 (wherein R 65 is a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms of which one is N and the other is selected independently from O, S and N, which heterocyclic group is linked to d-salkyl through a nitrogen atom and which heterocyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, Cι -4 alkyl, Cι -4 hy droxy alkyl and Cι -4 alkoxy); 7) C 3-4 alkenylR 66 (wherein R 66 represents R 64 or R 65 as defined hereinbefore); 8) C 3-4 alkynylR 66 (wherein R 66 represents R 64 or R 65 as defined hereinbefore); 9) R 39 (wherein R 39 is as defined hereinbefore); 10) (wherein R 39 is as defined hereinbefore); 11) C 3-4 alkenylR 39 (wherein R 39 is as defined hereinbefore); 12) C 3- alkynylR 39 (wherein R 39 is as defined hereinbefore); 13) C 2-4 alkylX 12 R 39 (wherein X 12 and R 39 are as defined hereinbefore); 14) C 4 . 5 alkenylX 13 R 39 (wherein X 13 and R 39 are as defined hereinbefore); 15) C 4 - 5 alkynylX 14 R 39 (wherein X 14 and R 39 are as defined hereinbefore); and 16) C 2-3 alkylX 15 Cι -2 alkylR 39 (wherein X 15 and R 39 are as defined hereinbefore); and 17) C 2-3 alkylX 15 Cι -2 alkylR 38 (wherein X 15 and R 38 are as defined hereinbefore)]. Advantageously R 3 represents hydroxy, halogeno, nitro, trifluoromethyl, Cι -3 alkyl, cyano, amino or R 15 X 7 [wherein X 7 is as hereinbefore defined and R 15 is selected from one of the following seventeen groups: 1) which may be unsubstituted or substituted with one or more fluorine atoms, or C 2- 4 alkyl which may be unsubstituted or substituted with one or two groups selected from hydroxy and amino; 2) C 2-3 alkylX 8 COR 21 (wherein X 8 is as hereinbefore defined and R 21 represents -NR 23 R 24 - or - OR 25 - (wherein R 23 , R 24 and R 25 which may be the same or different are each Cι -2 alkyl or Ci. 2 alkoxyethyl)); 3) C 2 - 4 alkylX 9 R 26 (wherein X 9 is as hereinbefore defined and R 26 is a group selected from Cj. 3 alkyl, cyclopentyl, cyclohexyl, pyrrolidinyl and piperidinyl which group is linked to X 9 through a carbon atom and which Cι -3 alkyl group may bear one or two substituents selected from oxo, hydroxy, halogeno and Cι -2 alkoxy and which cyclopentyl, cyclohexyl, pyrrolidinyl or piperidinyl group may carry one substituent selected from oxo, hydroxy, halogeno, d. 2 alkyl, Cι -2 hydroxyalkyl and C| -2 alkoxy); 4) C 2-3 alkylX 10 C 2-3 alkylX 11 R 32 (wherein X 10 and X 11 are as hereinbefore defined and R 32 represents hydrogen or Cι -3 alkyl); 5) R 38 (wherein R 38 is as defined hereinbefore); 6) Cι -4 alkylR 67 (wherein R 67 is a group selected from pyrrolidinyl, piperazinyl, piperidinyl, l,3-dioxolan-2-yl, l,3-dioxan-2-yl, l,3-dithiolan-2-yl and l,3-dithian-2-yl, which group is linked to Cι -4 alkyl through a carbon atom and which group may carry one or two substituents selected from oxo, hydroxy, halogeno, Cι- alkyl, Cι -2 hydroxy alkyl and Cι -2 alkoxy) or C 2- 4alkylR 68 (wherein R 68 is a group selected from morpholino, thiomorpholino, pyrrolidin-1-yl, piperazin- 1-yl and piperidino which group may carry one or two substituents selected from oxo, hydroxy, halogeno, C| -2 alkyl, Cι -2 hydroxyalkyl and d -2 alkoxy); 7) C 3-4 alkenylR 69 (wherein R 69 represents R 67 or R 68 as defined hereinbefore); 8) C 3-4 alkynylR 69 (wherein R 69 represents R 67 or R 68 as defined hereinbefore); 9) R 39 (wherein R 39 is as defined hereinbefore); 10) (wherein R 39 is as defined hereinbefore); 11) l-R 39 prop-l-en-3-yl or l-R 39 but-2-en-4-yl (wherein R 39 is as defined hereinbefore with the proviso that when R 15 is l-R 39 prop-l-en-3-yl, R 39 is linked to the alkenyl group via a carbon atom); 12) l-R 39 prop-l-yn-3-yl or l-R 39 but-2-yn-4-yl (wherein R 39 is as defined hereinbefore with the proviso that when R 15 is l-R 39 prop-l-yn-3-yl, R 39 is linked to the alkynyl group via a carbon atom); 13) C 2-4 alkylX 12 R 39 (wherein X 12 and R 39 are as defined hereinbefore); 14) l-(R 39 X 13 )but-2-en-4-yl (wherein X 13 and R 39 are as defined hereinbefore); 15) l-(R 39 X 14 )but-2-yn-4-yl (wherein X 14 and R 39 are as defined hereinbefore); 16) C 2 . 3 alkylX 15 Cι. 2 alkylR 39 (wherein X 15 and R 39 are as defined hereinbefore); and 17) C 2-3 alkylX 15 Cι. 2 alkylR 38 (wherein X 15 and R 38 are as defined hereinbefore)]. Preferably R 3 represents hydroxy, halogeno, nitro, trifluoromethyl, Cι -3 alkyl, cyano, amino or R 15 X 7 [wherein X 7 is as hereinbefore defined and R 15 is selected from one of the following fifteen groups: 1) Cι -3 alkyl which may be unsubstituted or substituted with one or more fluorine atoms, or C 2- 3 alkyl which may be unsubstituted or substituted with one or two groups selected from hydroxy and amino; 2) 2-(3,3-dimethylureido)ethyl, 3-(3,3-dimethylureido)propyl, 2-(3-methylureido)ethyl, 3-(3- methylureido)propyl, 2-ureidoethyl, 3-ureidopropyl, 2-(N,N-dimethylcarbamoyloxy)ethyl, 3- (N,N-dimethylcarbamoyloxy)propyl, 2-(N-methylcarbamoyloxy)ethyl, 3-(N- methylcarbamoyloxy)propyl, 2-(carbamoyloxy)ethyl, 3-(carbamoyloxy)propyl; 3) C 2-3 alkylX 9 R 26 (wherein X 9 is as defined hereinbefore and R 26 is a group selected from C \ . 2 alkyl, cyclopentyl, cyclohexyl, pyrrolidinyl and piperidinyl which group is linked to X 9 through a carbon atom and which group may bear one or two substituents selected from hydroxy, halogeno and and which cyclopentyl, cyclohexyl, pyrrolidinyl or piperidinyl group may carry one substituent selected from oxo, hydroxy, halogeno, Cι -2 alkyl, Cι -2 hy droxy alkyl and Cι -2 alkoxy); 4) C 2-3 alkylX 10 C 2 - 3 alkylX π R 32 (wherein X 10 and X 11 are as hereinbefore defined and R 32 represents hydrogen or Cι -2 alkyl); 5) R 38 (wherein R 38 is as defined hereinbefore); 6) Cι. 2 alkylR 67 (wherein R 67 is a group selected from pyrrolidinyl, piperazinyl, piperidinyl, l,3-dioxolan-2-yl, l,3-dioxan-2-yl, l,3-dithiolan-2-yl and l,3-dithian-2-yl, which group is linked to C^alkyl through a carbon atom and which group may carry one substituent selected from oxo, hydroxy, halogeno, d. 2 alkyl, Cι. 2 hydroxyalkyl and Cι. 2 alkoxy) or C 2-3 alkylR 68 (wherein R 68 is a group selected from morpholino, thiomorpholino, piperidino, piperazin- 1-yl and pyrrolidin-1-yl which group may carry one or two substituents selected from oxo, hydroxy, halogeno, d -2 alkyl, Cι -2 hydroxy alkyl and d -2 alkoxy); 7) R 39 (wherein R 39 is as defined hereinbefore); 8) C^alkylR 39 (wherein R 39 is as defined hereinbefore); 9) l-R 39 but-2-en-4-yl (wherein R 39 is as defined hereinbefore); 10) l-R 39 but-2-yn-4-yl (wherein R 39 is as defined hereinbefore); 11) C 2 - 4 alkylX 12 R 39 (wherein X 12 and R 39 are as defined hereinbefore); 12) l-(R 39 X 13 )but-2-en-4-yl (wherein X 13 and R 39 are as defined hereinbefore); 13) l-(R 39 X 14 )but-2-yn-4-yl (wherein X 14 and R 39 are as defined hereinbefore); 14) ethylX 15 methylR 39 (wherein X 15 and R 39 are as defined hereinbefore); and 15) ethylX I5 methylR 38 (wherein X 15 and R 38 are as defined hereinbefore)]. More preferably R 3 represents hydroxy, Cι -3 alkyl, amino or R 15 X 7 [wherein X 7 is as hereinbefore defined and R 15 represents 2-methylthiazol-4-ylmethyl, 2-acetamidothiazol-4- ylmethyl, l-methylimidazol-2-ylmethyl, 4-pyridylmethyl, 2-(4-pyridyl)ethyl, 3-(4- pyridyl)propyl, 2-((N-( l-methylimidazol-4-ylsulphonyl)-N-methyl)amino)ethyl, 2-((N-(3- mo holinopropylsulphonyl)-N-methyl)amino)ethyl, 2-((N-methyl-N-4-pyridyl)amino)ethyl, 2-(4-oxidomorpholino)ethyl, 3-(4-oxidomoφholino)propyl, 2-(4-oxo- 1 ,4-dihydro- 1 - pyridyl)ethyl, 3-(4-oxo-l,4-dihydro-l-pyridyl)propyl, methyl, ethyl, trifluoromethyl, 2,2,2- trifluoroethyl, 2-hydroxyethyl, 3-hydroxypropyl, 2-(N,N-dimethylsulphamoyl)ethyl, 2-(N- methylsulphamoyl)ethyl, (l,3-dioxolan-2-yl)methyl, 2-(l,3-dioxolan-2-yl)ethyl, 2-(2- methoxyethylamino)ethyl, 2-(2-hydroxyethylamino)ethyl, 3-(2-methoxyethylamino)propyl, 3- (2-hydroxyethylamino)propyl, 2-(l,2,4-triazol-l-yl)ethyl, 2-(l,2,4-triazol-4-yl)ethyl, 3-(l,2,4- triazol-l-yl)propyl, 3-(l,2,4-triazol-4-yl)propyl, 2-(4-pyridyloxy)ethyl, 3-(4- pyridyloxy)propyl, 2-(4-pyridylamino)ethyl, 3-(4-pyridylamino)propyl, 2-(2-methylimidazol- l-yl)ethyl, 3-(2-methylimidazol-l-yl)propyl, 2-(5-methyl-l,2,4-triazol-l-yl)ethyl, 3-(5-methyl- l,2,4-triazol-l-yl)propyl, morpholino, N-methylpiperazinyl, piperazinyl, 2-(N,N- dimethylamino)ethyl, 3-(N,N-dimethylamino)propyl, 2-morpholinoethyl, 3-morpholinopropyl, 2-piperidinoethyl, 3-piperidinopropyl, 2-(piperazin-l-yl)ethyl, 3-(piperazin-l-yl)propyl, 2- (pyrrolidin-l-yl)ethyl, 3-(pyrrolidin-l-yl)propyl, 2-methoxyethyl, 3-methoxypropyl, 2- (imidazol-l-yl)ethyl, 2-(l,2,3-triazol-l-yl)ethyl, 2-(l,2,3-triazol-2-yl)ethyl, 3-(imidazol-l- yl)propyl, 3-( 1 ,2,3-triazol- 1 -yl)propyl, 3-( 1 ,2,3-triazol-2-yl)propyl, 2-thiomoφholinoethyl, 3- thiomoφholinopropyl, 2-( 1 , 1 -dioxothiomoφholino)ethyl, 3-( 1 , 1 -dioxothiomoφholino)propyl, 2-(2-methoxyethoxy)ethyl, 2-(4-methylρiperazin-l-yl)ethyl, 3-(4-methylpiperazin-l-yl)propyl, 3-(methylsulphinyl)propyl, 3-(methylsulphonyl)propyl, 2-(methylsulphinyl)ethyl or 2- (methylsulphonyl)ethyl] . Especially R 3 represents hydroxy, Cι -3 alkyl, amino or R 15 X 7 [wherein X 7 is as hereinbefore defined and R 15 represents methyl, ethyl, trifluoromethyl, 2,2,2-trifluoroethyl, 2-hydroxyethyl, 3-hydroxypropyl, 2-(N,N-dimethylsulphamoyl)ethyl, 2-(N-methylsulphamoyl)ethyl, (1,3- dioxolan-2-yl)methyl, 2-(l,3-dioxolan-2-yl)ethyl, 2-(2-methoxyethylamino)ethyl, 2-(2- hydroxyethylamino)ethyl, 3-(2-methoxyethylamino)propyl, 3-(2-hydroxyethylamino)propyl, 2-(l,2,4-triazol-l-yl)ethyl, 2-(l,2,4-triazol-4-yl)ethyl, 3-(l,2,4-triazol-l-yl)propyl, 3-(l,2,4- triazol-4-yl)propyl, 2-(4-pyridyloxy)ethyl, 3-(4-pyridyloxy)propyl, 2-(4-pyridylamino)ethyl, 3- (4-pyridylamino)propyl, 2-(2-methylimidazol-l-yl)ethyl, 3-(2-methylimidazol-l-yl)propyl, 2- (5-methyl-l,2,4-triazol-l-yl)ethyl, 3-(5-methyl-l,2,4-triazol-l-yl)propyl, moφholino, N- methylpiperazinyl, piperazinyl, 2-(N,N-dimethylamino)ethyl, 3-(N,N-dimethylamino)propyl, 2-moφholinoethyl, 3-moφholinopropyl, 2-piperidinoethyl, 3-piperidinopropyl, 2-(piperazin- l-yl)ethyl, 3-(piperazin-l-yl)propyl, 2-(pyrrolidin-l-yl)ethyl, 3-(pyrrolidin-l-yl)propyl, 2- methoxyethyl, 3-methoxypropyl, 2-(imidazol-l-yl)ethyl, 2-(l,2,3-triazol-l-yl)ethyl, 2-(l,2,3- triazol-2-yl)ethyl, 3-(imidazol-l-yl)propyl, 3-(l,2,3-triazol-l-yl)propyl, 3-(l,2,3-triazol-2- yl)propyl, 2-thiomoφholinoethyl, 3-thiomoφholinopropyl, 2-(l,l-dioxothiomoφholino)ethyl, 3-( 1 , 1 -dioxothiomoφholino)proρyl, 2-(2-methoxyethoxy)ethyl, 2-(4-methylpiperazin- 1 - yl)ethyl, 3-(4-methylpiperazin-l-yl)propyl, 3-(methylsulphinyl)propyl, 3- (methylsulphonyl)propyl, 2-(methylsulphinyl)ethyl or 2-(methylsulphonyl)ethyl. More especially R 3 represents hydroxy, Cι -3 alkyl, amino or R 15 X 7 [wherein X 7 is as hereinbefore defined and R 15 represents 2-(N,N-dimethylamino)ethyl, 3-(N,N- dimethylamino)propyl, 2-moφholinoethyl, 3-moφholinopropyl, 2-piperidinoethyl, 3- piperidinopropyl, 2-(piperazin-l-yl)ethyl, 3-(piperazin-l-yl)propyl, 2-(pyrrolidin-l-yl)ethyl, 3- (pyrrolidin-l-yl)propyl, 2-methoxyethyl, 3-methoxypropyl, 2-(imidazol-l-yl)ethyl, 2-( 1,2,3- triazol-l-yl)ethyl, 2-(l,2,3-triazol-2-yl)ethyl, 3-(imidazol-l-yl)propyl, 3-(l,2,3-triazol-l- yl)propyl, 3-(l,2,3-triazol-2-yl)propyl, 2-thiomoφholinoethyl, 3-thiomoφholinopropyl, 2- (1,1 -dioxothiomoφholino)ethyl, 3-( 1 , 1 -dioxothiomoφholino)propyl, 2-(2- methoxyethoxy)ethyl, 2-(4-methylpiperazin-l-yl)ethyl, 3-(4-methylpiperazin-l-yl)propyl, 3- (methylsulphinyl)propyl, 3-(methylsulphonyl)propyl, 2-(methylsulphinyl)ethyl or 2- (methylsulphonyl)ethyl. Where one of the R 3 substituents is R 15 X 7 the substituent R 15 X 7 is preferably at the 6 or 7- position of the quinazoline ring, more preferably at the 7-position of the quinazoline ring. In a particular aspect of the current invention there are provided compounds of the formula la: (la) [wherein: R 1 , R 2 , ring Z and n are as defined hereinbefore; R 3a represents hydrogen, hydroxy, methoxy, amino, nitro or halogeno; R 4a represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, Cι -3 alkyl, Cι_ 3 alkoxy, Cι -3 alkylthio, -NR 6a R 7a - (wherein R 6a and R 7a , which may be the same or different, each represents hydrogen or Cι -3 alkyl), or a group R ,8 o a a ( / CH 2 )taX r2a a (wherein R 8a is a 5 or 6- membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, Cι- alkyl, Cι- hy droxy alkyl and Cι- alkoxy, ta is an integer from 0 to 4 and X 2a represents a direct bond, -O-, -CH 2 -, -S-, -SO-, -SO 2 -, -NR 9a CO-, -CONR 10a -, - SO 2 NR l la -, -NR 12a SO 2 - or -NR 13a - (wherein R 9a , R 10 \ R l la , R 12a and R 13a each independently represents hydrogen, C !-3 alkyl or Cι -3 alkoxyC 2 . 3 alkyl)); X la represents a direct bond, -O-, -CH 2 -, -S-, -SO-, -SO 2 -, -NR 14a CO-, -CONR 15a -, - SO 2 NR 16a -, -NR 17a SO 2 - or -NR 18a - (wherein R 14a , R 15a , R 16a , R 17a and R l8a each independently represents hydrogen, Cι. 3 alkyl or Cι. 3 alkoxyC 2 - 3 alkyl); R 5a is selected from one of the following seventeen groups: 1) hydrogen or Ci.salkyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy, fluoro and amino; 2) C, -5 alkylX 3a COR 19a (wherein X 3a represents -O- or -NR 20a - (in which R 20a represents hydrogen, Cι -3 alkyl or Cι -3 alkoxyC 2-3 alkyl) and R 19a represents Cι -3 alkyl, -NR 21a R 22a - or - OR 23a - (wherein R 21a , R 22a and R 23a which may be the same or different each represents hydrogen, C i . 3 alkyl or C i . 3 alkoxy C 2-3 alkyl)) ; 3) Cι -5 alkylX 4a R 24a (wherein X 43 represents -O-, -S-, -SO-, -SO 2 -, -OCO-, -NR 25a CO-, - CONR 26a -, -SO 2 NR 27a -, -NR 28a SO 2 - or -NR 29a - (wherein R 25a , R 26a , R 27a , R 28a and R 29a each independently represents hydrogen, Cι. 3 alkyl or Cι -3 alkoxyC2 -3 alkyl) and R 24a represents hydrogen, Cι -3 alkyl, cyclopentyl, cyclohexyl or a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which Cι -3 alkyl group may bear one or two substituents selected from oxo, hydroxy, halogeno and Cι -4 alkoxy and which cyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, Cι- alkyl, Cι- hy droxy alkyl and Cι-4alkoxy); 4) Cι -5 alkylX 5a Cι -5 alkylX 6a R 30a (wherein X 5a and X 6a which may be the same or different are each -O-, -S-, -SO-, -SO 2 -, -NR 31a CO-, -CONR 32a -, -SO 2 NR 33 \ -NR 34a SO 2 - or -NR 35a - (wherein R 31a , R 32a , R 33a , R 34a and R 35a each independently represents hydrogen, Cι -3 alkyl or Cι. 3 alkoxyC 2-3 alkyl) and R 30a represents hydrogen or Cι -3 alkyl); 5) R 36a (wherein R 36a is a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, d- hy droxy alkyl and d_ 4alkoxy); 6) Cι -5 alkylR 36a (wherein R 36a is as defined hereinbefore); 7) C 2- salkenylR 36a (wherein R 36a is as defined hereinbefore); 8) C 2-5 alkynylR 36a (wherein R 36a is as defined hereinbefore); 9) R 37a (wherein R 37a represents a pyridone group, a phenyl group or a 5 or 6-membered aromatic heterocyclic group with 1 to 3 heteroatoms selected from O, N and S, which pyridone, phenyl or heterocyclic group may carry up to 5 substituents selected from hydroxy, halogeno, amino, C aminoalkyl, Ci- 4 hydroxyalkoxy, carboxy, trifluoromethyl, cyano, -CONR 38a R 39a and -NR^COR 413 - (wherein R 38a , R 39a , R 403 and R 41a , which may be the same or different, each represents hydrogen, d. 4 alkyl or Cι. 3 alkoxyC 2-3 alkyl)); 10) Cι. 5 alkylR 37a (wherein R 37a is as defined hereinbefore); 11) C 2-5 alkenylR 37a (wherein R 37a is as defined hereinbefore); 12) C 2 - 5 alkynylR 37a (wherein R 37a is as defined hereinbefore); 13) Cι -5 alkylX 7a R 37a (wherein X 7a represents -O-, -S-, -SO-, -SO 2 -, -NR 42a CO-, -CONR 43a -, - SO 2 NR 443 -, -NR 45a SO 2 - or -NR 463 - (wherein R 42a , R 43a , R 443 , R 45a and R 463 each independently represents hydrogen, Cι -3 alkyl or Cι -3 alkoxyC2 -3 alkyl) and R 37a is as defined hereinbefore); 14) C 2-5 alkenylX 83 R 37a (wherein X 8a represents -O-, -S-, -SO-, -SO 2 -, -NR 47a CO-, -CONR 483 -, -SO 2 NR 49a -, -NR 50a SO 2 - or -NR 51a - (wherein R 47a , R 48a , R 49a , R 50a and R 51a each independently represents hydrogen, Cι -3 alkyl or Cι -3 alkoxyC2 -3 alkyl) and R 37a is as defined hereinbefore); 15) C 2 . 5 alkynylX 9a R 37a (wherein X 9a represents -O-, -S-, -SO-, -SO 2 -, -NR 52a CO-, -CONR 53a -, -SO 2 NR 54a -, -NR 55a SO 2 - or -NR 56a - (wherein R 52a , R 53a , R 54a , R 55a and R 56a each independently represents hydrogen, Cι -3 alkyl or Cι -3 alkoxyC 2-3 alkyl) and R 37a is as defined hereinbefore); 16) C,. 3 alkylX 10a Cι -3 alkylR 37a (wherein X 10a represents -O-, -S-, -SO-, -SO 2 -, -NR 57a CO-, - CONR 583 -, -SO 2 NR 59a -, -NR 60a SO 2 - or -NR 61a - (wherein R 57a , R 58a , R 59a , R 60a and R 61a each independently represents hydrogen, C 1-3 alkyl or C 1-3 alkoxyC 2-3 alkyl) and R 37a is as defined hereinbefore); and 17) Cι -3 alkylX 10a C, -3 alkylR 36a (wherein X l0a and R 36a are as defined hereinbefore)]; and salts thereof. Preferably R 3a represents hydrogen, amino, nitro or halogeno, but especially hydrogen. Advantageously X 2a represents -O-, -S-, -NR 9a CO-, -NR 12a SO 2 - or -NR 13a - (wherein R 9a , R 12a and R 13a each independently represents hydrogen, Cι -2 alkyl or C| -2 alkoxyethyl). Preferably X 23 represents -O-, -S-, -NR 9a CO-, -NR 12a SO 2 - (wherein R 9a and R 1 a each independently represents hydrogen or or NH. More preferably X 2a represents -O-, -S-, -NR 9a CO- (wherein R 9a represents hydrogen or d- 2 alkyl) or NH. Particularly X 23 represents -O- or -NR 9a CO- (wherein R 9a represents hydrogen or Cι -2 alkyl), more particularly -O- or -NHCO-, especially -O-. Preferably ta is an integer from 1 to 3. Preferably R 8a is a group selected from pyrrolidinyl, piperazinyl, piperidinyl, moφholino and thiomoφholino which group may carry one or two substituents selected from oxo, hydroxy, halogeno, d -2 alkyl, C 1-2 hydroxyalkyl and d -2 alkoxy. Advantageously R 4a represents hydrogen, hydroxy, cyano, nitro, trifluoromethyl, Cι -3 alkyl, Ci- 3 alkoxy, amino or a group R 8a (CH2)t a X 2a (wherein R 8a , X 2a and ta are as defined hereinbefore). Preferably R 4a is hydrogen, hydroxy, cyano, nitro, trifluoromethyl, methyl, ethyl, methoxy, ethoxy or a group R 8a (CH 2 ) ta X 2a (wherein R 8a , X 2a and ta are as defined hereinbefore). More preferably R 4a is hydrogen, hydroxy, cyano, nitro, trifluoromethyl, methyl, ethyl, methoxy, ethoxy or R 8a (CH 2 ) t aX 2a (wherein R 8a is a group selected from pyrrolidinyl, piperazinyl, piperidinyl, moφholino and thiomoφholino which group may carry one or two substituents selected from oxo, hydroxy, halogeno, Cι -2 alkyl, C 1-2 hydroxyalkyl and Ci. 2 alkoxy, X 2a is -O-, -S-, -NR 9a CO-, -NR 12a SO 2 - (wherein R 9a and R 12a each independently represents hydrogen or Cι -2 alkyl) or NH and ta is an integer from 1 to 3). Particularly R 4a represents hydrogen, hydroxy, cyano, nitro, trifluoromethyl, methyl, methoxy or R 8a (CH 2 ) ta X 2a (wherein R 8a , X 2a and ta are as defined hereinbefore). More particularly R 4a represents hydrogen or methoxy. R 4a especially represents methoxy. Advantageously X la represents -O-, -S-, -NR 14a CO-, -NR 17a SO 2 - or -NR 18a - (wherein R 14a , R 17a and R 18a each independently represents hydrogen, Cι -2 alkyl or Cι -2 alkoxyethyl). Preferably X la represents -O-, -S-, -NR l4a CO-, -NR 17a SO 2 - (wherein R 14a and R 17a each independently represents hydrogen or C 1-2 alkyl) or NH. More preferably X la represents -O-, -S-, -NR 14a CO- (wherein R 14a represents hydrogen or Cj. 2 alkyl) or NH. Particularly X Ia represents -O- or -NR 14a CO- (wherein R 14a represents hydrogen or Cι_ 2 alkyl), more particularly -O- or -NHCO-, especially -O-. Advantageously X 3a represents -O- or NR 20a (wherein R 20a represents hydrogen, Cι -3 alkyl or Cι -2 alkoxyethyl). Advantageously X 43 represents -O-, -S-, -SO-, -SO 2 -, -NR 25a CO-, -NR 28a SO 2 - or -NR 29a - (wherein R 253 , R 28a and R 29a each independently represents hydrogen, Cι -2 alkyl or Ci- 2alkoxy ethyl). Preferably X 4a represents -O-, -S-, -SO-, -SO 2 - or -NR 29a - (wherein R 29a represents hydrogen, Cι -2 alkyl or Cι -2 alkoxyethyl). More preferably X 4a represents -O-, -SO 2 - or -NR 29a - (wherein R 29a represents hydrogen or Ci. 2 alkyl). Advantageously X 5a and X 6a which may be the same or different each represents -O-, -S-, - SO-, -SO 2 - or -NR 35a - (wherein R 35a represents hydrogen, Cι -3 alkyl or Cι. 2 alkoxyethyl). Preferably X 5a and X 6a which may be the same or different each represents -O-, -S-, -SO 2 - or - NR 35a - (wherein R 35a represents hydrogen, d -2 alkyl or C 1-2 alkoxyethyl). More preferably X 5a and X 6a which may be the same or different each represents -O-, -SO 2 - or -NH-. Advantageously X 7a represents -O-, -S-, -SO 2 - or -NR 463 - (wherein R 463 represents hydrogen, C i -2 alky 1 or C i -2 alkoxy ethyl) . Preferably X 7a represents -O-, -SO 2 - or -NR 46a - (wherein R 46a represents hydrogen or Cι_ 2 alkyl). Advantageously X 8a represents -O-, -S-, -SO 2 - or -NR 51a - (wherein R 51a represents hydrogen, or Cι -2 alkoxy ethyl). Preferably X 8a represents -O-, -SO 2 - or -NR 51a - (wherein R 51a represents hydrogen or Ci. 2 alkyl). Advantageously X 9a represents -O-, -S-, -SO2- or -NR 56a - (wherein R 56a represents hydrogen, Ci. ∑ alkyi or Cι- 2 alkoxyethyl). Preferably X 9a represents -O-, -SO 2 - or -NR 56a - (wherein R 56a represents hydrogen or d. 2 alkyl). Advantageously X 10a represents -O-, -S-, -SO 2 - or -NR 61a - (wherein R 61a represents hydrogen, Cι -2 alkyl or Cι. 2 alkoxyethyl). Preferably X 10a represents -O-, -SO2- or -NR 61a - (wherein R 61a represents hydrogen or d. 2 alkyl). R 36a is preferably pyrrolidinyl, piperazinyl, piperidinyl, moφholino or thiomoφholino which group may carry one or two substituents selected from oxo, hydroxy, halogeno, Cι -2 alkyl, Cj. 2hydroxyalkyl and More preferably R 36a is pyrrolidinyl, piperazinyl, piperidinyl, moφholino, thiomoφholino, 1- methylpiperazinyl or 1-ethylpiperazinyl which group may carry one or two oxo substituents. R 37a preferably represents a pyridone group or a 5 or 6-membered aromatic heterocyclic group with 1 to 3 heteroatoms selected from O, N and S, which pyridone group or heterocyclic group may be substituted as hereinbefore defined. Where R 37a is a 5 or 6-membered aromatic heterocyclic group, it preferably has 1 or 2 heteroatoms, selected from O, N and S, of which more preferably one is N, and may be substituted as hereinbefore defined. R 37a is particularly a pyridone, pyridyl, imidazolyl, thiazolyl, thienyl, triazolyl, pyridazinyl or pyrazinyl group which group may be substituted as hereinbefore defined, more particularly a pyridone, pyridyl, imidazolyl, thiazolyl or triazolyl group, especially a pyridone, pyridyl, imidazolyl or triazolyl group which group may be substituted as hereinbefore defined. In one embodiment of the invention R 37a represents a pyridone, phenyl or 5 or 6-membered aromatic heterocyclic group with 1 to 3 heteroatoms selected from O, N and S, which group may preferably carry up to 2 substituents, more preferably up to one substituent, selected from the group of substituents as hereinbefore defined. In the definition of R 37a , conveniently substituents are selected from halogeno, Cι -4 alkyl, C \ . 4 alkoxy, trifluoromethyl and cyano, more conveniently substituents are selected from chloro, fluoro, methyl, ethyl and trifluoromethyl. Conveniently R 5a is selected from one of the following seventeen groups: 1) Ci.salkyl which may be unsubstituted or substituted with one or more fluorine atoms, or C 2 - salkyl which may be unsubstituted or substituted with one or more groups selected from hydroxy and amino; 2) C 2-3 alkylX 3a COR 19a (wherein X 3a is as hereinbefore defined and R 19a represents Cι -3 alkyl, - NR 21a R 2a - or -OR 23a - (wherein R 21a , R 22a and R 23a which may be the same or different are each Cι -2 alkyl or Cι -2 alkoxyethyl)); 3) C 2-4 alkylX 4a R 243 (wherein X 4a is as hereinbefore defined and R 24a represents hydrogen, d. 3 alkyl, cyclopentyl, cyclohexyl or a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which Cι -3 alkyl group may bear one or two substituents selected from oxo, hydroxy, halogeno and Cι -3 alkoxy and which cyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, d- 4hydroxyalkyl and 4) C 2-3 alkylX 5a C 2-3 alkylX 6a R 30a (wherein X 5a and X 6a are as hereinbefore defined and R 30a represents hydrogen or Cι -3 alkyl); 5) R 36a (wherein R 36a is as defined hereinbefore); 6) Cι- 4 alkylR 62a (wherein R 62a is a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group is linked to Cι. 4 alkyl through a carbon atom and which heterocyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, Cι- alkyl, Cι -4 hydroxyalkyl and C alkoxy) or C 2 - 5 alkylR 63a (wherein R 63a is a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms of which one is N and the other is selected independently from O, S and N, which heterocyclic group is linked to d-salkyl through a nitrogen atom and which heterocyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, C alkyl, Cι- hydroxy alkyl and d- alkoxy); 7) C^alkenylR 643 (wherein R 643 represents R 62a or R 63a as defined hereinbefore); 8) C^alkynylR 643 (wherein R 643 represents R 62a or R 63a as defined hereinbefore); 9) R 37a (wherein R 37a is as defined hereinbefore); 10) Cι -4 alkylR 37a (wherein R 37a is as defined hereinbefore); 11) C 3-4 alkenylR 37a (wherein R 37a is as defined hereinbefore); 12) C 3-4 alkynylR 37a (wherein R 37a is as defined hereinbefore); 13) C 2-4 alkylX 7a X 37a (wherein X 7a and R 37a are as defined hereinbefore); 14) C 4 - 5 alkenylX 8a R 37a (wherein X 8a and R 37a are as defined hereinbefore); 15) C 4 - 5 alkynylX 9a R 37a (wherein X 9a and R 37a are as defined hereinbefore); 16) C 2-3 alkylX 10a Cι -2 alkylR 37a (wherein X 10a and R 37a are as defined hereinbefore); and 17) C 2-3 alkylX 10a Cι -2 alkylR 36a (wherein X 10a and R 36a are as defined hereinbefore). Advantageously R 5a is selected from one of the following seventeen groups: 1) Cι- alkyl which may be unsubstituted or substituted with one or more fluorine atoms, or C 2 . 4alkyl which may be unsubstituted or substituted with one or two groups selected from hydroxy and amino; 2) C 2-3 alkylX 3a COR 19a (wherein X 3a is as hereinbefore defined and R 19a represents -NR 21a R 22a - or -OR 23a - (wherein R 21a , R 22a and R 23a which may be the same or different are each d. 2 alkyl or Cι -2 alkoxyethyl)); 3) C 2- alkylX 4a R 24a (wherein X 4a is as hereinbefore defined and R 24a is a group selected from Cι -3 alkyl, cyclopentyl, cyclohexyl, pyrrolidinyl and piperidinyl which group is linked to X 4a through a carbon atom and which Cι -3 alkyl group may bear one or two substituents selected from oxo, hydroxy, halogeno and and which cyclopentyl, cyclohexyl, pyrrolidinyl or piperidinyl group may carry one substituent selected from oxo, hydroxy, halogeno, Ci. 2 alkyl, Cι. 2 hy droxy alkyl and Cι -2 alkoxy); 4) C 2-3 alkylX 53 C 2-3 alkylX 63 R 30a (wherein X 5a and X 6a are as hereinbefore defined and R 30a represents hydrogen or Cι -3 alkyl); 5) R 36a (wherein R 36a is as defined hereinbefore); 6) Cι- alkylR 65a wherein R 65a is a group selected from pyrrolidinyl, piperazinyl, piperidinyl, l,3-dioxolan-2-yl, l,3-dioxan-2-yl, l,3-dithiolan-2-yl and l,3-dithian-2-yl, which group is linked to C alkyl through a carbon atom and which group may carry one or two substituents selected from oxo, hydroxy, halogeno, d -2 alkyl, Cι -2 hy droxy alkyl and Cι -2 alkoxy) or C 2 - 4 alkylR 66 (wherein R 663 is a group selected from moφholino, thiomoφholino, pyrrolidin-1-yl, piperazin- 1-yl and piperidino which group may carry one or two substituents selected from oxo, hydroxy, halogeno, and 7) C 3-4 alkenylR 67a (wherein R 67a represents R 65a or R 66a as defined hereinbefore); 8) C 3-4 alkynylR 67a (wherein R 67a represents R 65a or R 66a as defined hereinbefore); 9) R 37a (wherein R 37a is as defined hereinbefore); 10) C, -4 alkylR 37a (wherein R 37a is as defined hereinbefore); 11) l-R 37a prop-l-en-3-yl or l-R 37a but-2-en-4-yl (wherein R 37a is as defined hereinbefore with the proviso that when R 5a is l-R 37a prop-l-en-3-yl, R 37a is linked to the alkenyl group via a carbon atom); 12) l-R 37a prop-l-yn-3-yl or l-R 37a but-2-yn-4-yl (wherein R 37a is as defined hereinbefore with the proviso that when R 5a is l-R 37a prop-l-yn-3-yl, R 37a is linked to the alkynyl group via a carbon atom); 13) C 2 - 4 alkylX 7a R 37a (wherein X 7a and R 37a are as defined hereinbefore); 14) l-(R 37a X 8a )but-2-en-4-yl (wherein X 8a and R 37a are as defined hereinbefore); 15) l-(R 37a X 9a )but-2-yn-4-yl (wherein X 9a and R 37a are as defined hereinbefore); 16) C 2-3 alkylX 10a C, -2 alkylR 37a (wherein X ,0a and R 37a are as defined hereinbefore); and 17) C 2-3 alkylX 10a C, -2 alkylR 36a (wherein X 10a and R 36a are as defined hereinbefore). Preferably R 5a is selected from one of the following fifteen groups: 1) Cι -3 alkyl which may be unsubstituted or substituted with one or more fluorine atoms, or C 2- 3 alkyl which may be unsubstituted or substituted with one or two groups selected from hydroxy and amino; 2) 2-(3,3-dimethylureido)ethyl, 3-(3,3-dimethylureido)proρyl, 2-(3-methylureido)ethyl, 3-(3- methylureido)propyl, 2-ureidoethyl, 3-ureidopropyl, 2-(N,N-dimethylcarbamoyloxy)ethyl, 3- (N,N-dimethylcarbamoyloxy)propyl, 2-(N-methylcarbamoyloxy)ethyl, 3-(N- methylcarbamoyloxy)propyl, 2-(carbamoyloxy)ethyl, 3-(carbamoyloxy)propyl; 3) C 2-3 alkylX 4a R 243 (wherein X 4a is as defined hereinbefore and R 24a is a group selected from Ci^alkyl, cyclopentyl, cyclohexyl, pyrrolidinyl and piperidinyl which group is linked to X 4a through a carbon atom and which Ci^alkyl group may bear one or two substituents selected from hydroxy, halogeno and and which cyclopentyl, cyclohexyl, pyrrolidinyl or piperidinyl group may carry one substituent selected from oxo, hydroxy, halogeno, Cι -2 alkyl, Cι- 2 hy droxy alkyl and 4) C 2-3 alkylX 5a C 2-3 alkylX 6a R 30a (wherein X 5a and X 6a are as hereinbefore defined and R 30a represents hydrogen or C i -2 alkyl) ; 5) R 36a (wherein R 36a is as defined hereinbefore); 6) Cι -2 alkylR 65a (wherein R 65a is a group selected from pyrrolidinyl, piperazinyl, piperidinyl, l,3-dioxolan-2-yl, l,3-dioxan-2-yl, l,3-dithiolan-2-yl and 1 ,3-dithian-2-yl, which group is linked to through a carbon atom and which group may carry one substituent selected from oxo, hydroxy, halogeno, Cι -2 alkyl, Cι -2 hydroxy alkyl and Cι -2 alkoxy) or C 2-3 alkylR 66a (wherein R 66a is a group selected from moφholino, thiomoφholino, piperidino, piperazin- 1-yl and pyrrolidin-1-yl which group may carry one or two substituents selected from oxo, hydroxy, halogeno, Cι -2 alkyl, Cι -2 hydroxy alkyl and d -2 alkoxy); 7) R 37a (wherein R 37a is as defined hereinbefore); 8) Cι -4 alkylR 37a (wherein R 37a is as defined hereinbefore); 9) l-R 37a but-2-en-4-yl (wherein R 37a is as defined hereinbefore); 10) l-R 37a but-2-yn-4-yl (wherein R 37a is as defined hereinbefore); 11) C 2-4 alkylX 73 R 37a (wherein X 7a and R 37a are as defined hereinbefore); 12) l-(R 37a X 8a )but-2-en-4-yl (wherein X 8a and R 37a are as defined hereinbefore); 13) 1 -(R 37a X 9a )but-2-yn-4-yl (wherein X 9a and R 37a are as defined hereinbefore); 14) ethylX 10a methylR 37a (wherein X 10a and R 37a are as defined hereinbefore); and 15) ethylX 10a methylR 36a (wherein X 10a and R 36a are as defined hereinbefore). More preferably R 5a represents 2-methylthiazol-4-ylmethyl, 2-acetamidothiazol-4-ylmethyl, 1- methylimidazol-2-ylmethyl, 4-pyridylmethyl, 2-(4-pyridyl)ethyl, 3-(4-pyridyl)propyl, 2-((N- ( l-methylimidazol-4-ylsulρhonyl)-N-methyl)amino)ethyl, 2-((N-(3- moφholinopropylsulphonyl)-N-methyl)amino)ethyl, 2-((N-methyl-N-4-pyridyl)amino)ethyl, 2-(4-oxidomoφholino)ethyl, 3-(4-oxidomoφholino)propyl, 2-(4-oxo- 1 ,4-dihydro- 1 - pyridyl)ethyl, 3-(4-oxo-l,4-dihydro-l-pyridyl)propyl, methyl, ethyl, trifluoromethyl, 2,2,2- trifluoroethyl, 2-hydroxyethyl, 3-hydroxypropyl, 2-(N,N-dimethylsulphamoyl)ethyl, 2-(N- methylsulphamoyl)ethyl, (l,3-dioxolan-2-yl)methyl, 2-(l,3-dioxolan-2-yl)ethyl, 2-(2- methoxyethylamino)ethyl, 2-(2-hydroxyethylamino)ethyl, 3-(2-methoxyethylamino)proρyl, 3- (2-hydroxyethylamino)propyl, 2-(l,2,4-triazol-l-yl)ethyl, 2-(l,2,4-triazol-4-yl)ethyl, 3-(l,2,4- triazol-l-yl)propyl, 3-(l,2,4-triazol-4-yl)propyl, 2-(4-pyridyloxy)ethyl, 3-(4- pyridyloxy)propyl, 2-(4-pyridylamino)ethyl, 3-(4-pyridylamino)propyl, 2-(2-methylimidazol- 1-yDethyl, 3-(2-methylimidazol-l-yl)ρropyl, 2-(5-methyl-l,2,4-triazol-l-yl)ethyl, 3-(5-methyl- l,2,4-triazol-l-yl)propyl, moφholino, N-methylpiperazinyl, piperazinyl, 2-(N,N- dimethylamino)ethyl, 3-(N,N-dimethylamino)propyl, 2-moφholinoethyl, 3-moφholinopropyl, 2-piperidinoethyl, 3-piperidinopropyl, 2-(piperazin-l-yl)ethyl, 3-(piperazin-l-yl)propyl, 2- (pyrrolidin-l-yl)ethyl, 3-(pyrrolidin-l-yl)propyl, 2-methoxyethyl, 3-methoxypropyl, 2- (imidazol-l-yl)ethyl, 2-(l,2,3-triazol-l-yl)ethyl, 2-(l,2,3-triazol-2-yl)ethyl, 3-(imidazol-l- yl)propyl, 3-(l,2,3-triazol-l-yl)propyl, 3-(l,2,3-triazol-2-yl)propyl, 2-thiomoφholinoethyl, 3- thiomoφholinopropyl, 2-( 1 , l-dioxothiomoφholino)ethyl, 3-( 1 , 1 -dioxothiomoφholino)propyl, 2-(2-methoxyethoxy)ethyl, 2-(4-methylpiperazin- 1 -yl)ethyl, 3-(4-methylpiperazin- 1 -yl)propyl, 3-(methylsulphinyl)propyl, 3-(methylsulphonyl)propyl, 2-(methylsulphinyl)ethyl or 2- (methylsulphonyl)ethyl. Especially R 5a represents methyl, ethyl, trifluoromethyl, 2,2,2-trifluoroethyl, 2-hydroxyethyl, 3-hydroxypropyl, 2-(N,N-dimethylsulphamoyl)ethyl, 2-(N-methylsulphamoyl)ethyl, (1,3- dioxolan-2-yl)methyl, 2-(l,3-dioxolan-2-yl)ethyl, 2-(2-methoxyethylamino)ethyl, 2-(2- hydroxyethylamino)ethyl, 3-(2-methoxyethylamino)propyl, 3-(2-hydroxyethylamino)propyl, 2-(l,2,4-triazol-l-yl)ethyl, 2-(l,2,4-triazol-4-yl)ethyl, 3-(l,2,4-triazol-l-yl)propyl, 3-(l,2,4- triazol-4-yl)propyl, 2-(4-pyridyloxy)ethyl, 3-(4-pyridyloxy)propyl, 2-(4-pyridylamino)ethyl, 3- (4-pyridylamino)propyl, 2-(2-methylimidazol- 1 -yl)ethyl, 3-(2-methylimidazol- 1 -yl)propyl, 2- (5-methyl-l,2,4-triazol-l-yl)ethyl, 3-(5-methyl-l,2,4-triazol-l-yl)propyl, moφholino, N- methylpiperazinyl, piperazinyl, 2-(N,N-dimethylamino)ethyl, 3-(N>N-dimethylamino)propyl, 2-moφholinoethyl, 3-moφholinopropyl, 2-piperidinoethyl, 3-piperidinopropyl, 2-(piperazin- l-yl)ethyl, 3-(piperazin-l-yl)propyl, 2-(pyrrolidin-l-yl)ethyl, 3-(pyrrolidin-l-yl)propyl, 2- methoxyethyl, 3-methoxypropyl, 2-(imidazol-l-yl)ethyl, 2-(l,2,3-triazol-l-yl)ethyl, 2-( 1,2,3- triazol-2-yl)ethyl, 3-(imidazol-l-yl)propyl, 3-(l,2,3-triazol-l-yl)propyl, 3-(l,2,3-triazol-2- yl)propyl, 2-thiomoφholinoethyl, 3-thiomoφholinopropyl, 2-(l,l-dioxothiomoφholino)ethyl, 3-( 1 , l-dioxothiomoφholino)propyl, 2-(2-methoxyethoxy)ethyl, 2-(4-methylpiperazin- 1 - yl)ethyl, 3-(4-methylpiperazin-l-yl)propyl, 3-(methylsulphinyl)propyl, 3- (methylsulphonyl)propyl, 2-(methylsulphinyl)ethyl or 2-(methylsulphonyl)ethyl. More especially R 5a 2-(N,N-dimethylamino)ethyl, 3-(N,N-dimethylamino)propyl, 2- moφholinoethyl, 3-moφholinopropyl, 2-piperidinoethyl, 3-piperidinopropyl, 2-(piperazin-l- yl)ethyl, 3-(piperazin-l-yl)propyl, 2-(pyrrolidin-l-yl)ethyl, 3-(pyrrolidin-l-yl)propyl, 2- methoxyethyl, 3-methoxypropyl, 2-(imidazol-l-yl)ethyl, 2-(l,2,3-triazol-l-yl)ethyl, 2-( 1,2,3- triazol-2-yl)ethyl, 3-(imidazol-l-yl)propyl, 3-(l,2,3-triazol-l-yl)propyl, 3-(l,2,3-triazol-2- yl)propyl, 2-thiomoφholinoethyl, 3-thiomoφholinopropyl, 2-(l,l-dioxothiomoφholino)ethyl, 3-( 1 , 1 -dioxothiomoφholino)propyl, 2-(2-methoxyethoxy)ethyl, 2-(4-methylpiperazin- 1 - yl)ethyl, 3-(4-methylpiperazin-l-yl)propyl, 3-(methylsulphinyl)propyl, 3- (methylsulphonyl)propyl, 2-(methylsulphinyl)ethyl or 2-(methylsulphonyl)ethyl. In a further aspect of the current invention there are provided compounds of the formula lb: (lb) [wherein: R , 1b represents hydrogen; R 2b represents halogeno, Cι. 2 alkyl, Cι. 2 alkoxy, trifluoromethyl, 2,2,2-trifluoroethyl, cyano, nitro, Cι. 3 alkanoylamino, Cι. 3 alkylsulphonyl, carbamoyl, N-Cι -3 alkylcarbamoyl, N,N-di(d. 3 alkyl)carbamoyl, aminosulphonyl, N-Cι-3alkylaminosulphonyl, N,N-di(Cι. 3 alkyl)aminosulphonyl or Cι. 3 alkylsulphonylamino or R is selected from one of the following four groups: 1) R 6b X 2b wherein X 2b represents -O-, -NR 7b -, C, -3 alkyl, -CONR 8b R 9b - or -SO 2 NR 10b R Ub - (wherein R 7b , R 8b , and R 10b , each independently represents hydrogen or Cι -2 alkyl and R 9b and R llb each independently represents Cι -3 alkyl and wherein R 6b is linked to R 9b or R l lb ) and R 6b represents a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group may bear two oxo substituents on a ring sulphur heteroatom; 2) X 3b C 2-3 alkyLX 4b methyl (wherein X 3b is -O- or -NR 12b - (wherein R 12b is hydrogen or C,. 2 alkyl) and X 4b is -O-, -NR 13b - or -SO 2 - (wherein R 13b is hydrogen or C, -2 alkyl); 3) Cι. 2 alkylX 5b C 2 - 3 alkylX 6b methyl (wherein X 5b and X 6b which may be the same or different are each -NR 14b - or -SO 2 - (wherein R 14b is hydrogen or Cι -2 alkyl); and 4) Cι. 2 alkylX 7b C, -2 alkyl (wherein X 7b is -O-, -NR 15b - or -SO 2 - (wherein R 15b is hydrogen or C, -2 alkyl); nb is an integer from 0 to 2; ring Zb is a 6-membered aromatic heterocyclic ring containing 1 or 2 nitrogen atoms such that the substituent at the 4-position of the quinazoline ring is selected from the groups 7- azaoxindol-3-yl and 5,7-diazaoxindol-3-yl which group bears (R 2b ) nb as defined hereinbefore; R 2b is attached at the 5- and or 6-ρositions of the heteroaromatic oxindole ring, but if R 2b is fluoro it can be attached at the 4-, 5-, 6- or 7-position(s) of the heteroaromatic oxindole ring; R represents hydrogen; R 4b represents represents hydrogen, hydroxy, cyano, nitro, trifluoromethyl, methyl, methoxy or a group R 16b (CH 2 ) tb X 8b (wherein R 16b represents a group selected from pyrrolidinyl, piperazinyl, piperidinyl, moφholino and thiomoφholino which group may carry one or two substituents selected from oxo, hydroxy, halogeno, Cι- alkyl, Cι -2 hy droxy alkyl and Cι_ 2 alkoxy, tb is an integer from 1 to 3 and X 8b represents -O-, -S-, -NR 17b CO-, -NR 18b SO 2 - (wherein R 17b and R 18b each independently represents hydrogen or C ]-2 alkyl) or NH); X lb represents -O- or -NR 19b CO- (wherein R 19b represents hydrogen or d. 2 alkyl); and R 5b represents methyl, ethyl, trifluoromethyl, 2,2,2-trifluoroethyl, 2-hydroxyethyl, 3- hydroxypropyl, 2-(N,N-dimethylsulphamoyl)ethyl, 2-(N-methylsulphamoyl)ethyl, (1,3- dioxolan-2-yl)methyl, 2-(l,3-dioxolan-2-yl)ethyl, 2-(2-methoxyethylamino)ethyl, 2-(2- hydroxyethylamino)ethyl, 3-(2-methoxyethylamino)propyl, 3-(2-hydroxyethylamino)propyl, 2-(l,2,4-triazol-l-yl)ethyl, 2-(l,2,4-triazol-4-yl)ethyl, 3-(l,2,4-triazol-l-yl)propyl, 3-(l,2,4- triazol-4-yl)propyl, 2-(4-pyridyloxy)ethyl, 3-(4-pyridyloxy)propyl, 2-(4-pyridylamino)ethyl, 3- (4-pyridylamino)propyl, 2-(2-methylimidazol-l-yl)ethyl, 3-(2-methylimidazol-l-yl)propyl, 2- (5-methyl-l,2,4-triazol-l-yl)ethyl, 3-(5-methyl-l,2,4-triazol-l-yl)propyl, moφholino, N- methylpiperazinyl, piperazinyl, 2-(N,N-dimethylamino)ethyl, 3-(N,N-dimethylamino)propyl, 2-moφholinoethyl, 3-moφholinopropyl, 2-piperidinoethyl, 3-piperidinopropyl, 2-(piperazin- l-yl)ethyl, 3-(piperazin-l-yl)propyl, 2-(pyrrolidin-l-yl)ethyl, 3-(pyrτolidin-l-yl)propyl, 2- methoxyethyl, 3-methoxypropyl, 2-(imidazol-l-yl)ethyl, 2-(l,2,3-triazol-l-yl)ethyl, 2-(l,2,3- triazol-2-yl)ethyl, 3-(imidazol-l-yl)propyl, 3-(l,2,3-triazol-l-yl)propyl, 3-(l,2,3-triazol-2- yl)propyl, 2-thiomoφholinoethyl, 3-thiomoφholinopropyl, 2-(l,l-dioxothiomoφholino)ethyl, 3-( 1 , 1 -dioxothiomoφholino)propyl, 2-(2-methoxyethoxy)ethyl, 2-(4-methylpiperazin- 1 - yl)ethyl, 3-(4-methylpiperazin-l-yl)propyl, 3-(methylsulphinyl)propyl, 3- (methylsulphonyl)propyl, 2-(methylsulphinyl)ethyl or 2-(methylsulphonyl)ethyl;] and salts thereof. Preferred compounds are 4-(7-azaoxindol-3-yl)-7-methoxy-6-(3-moφholinopropoxy)quinazoline, 4-(7-azaoxindol-3-yl)-6-methoxy-7-(2-methoxyethoxy)quinazoline and 4-(7-azaoxindol-3-yl)-6-methoxy-7-(2-(pyrrolidin-l-yl)ethoxy)quinazoline and salts thereof, particularly hydrochloride salts thereof. More preferred compounds are 4-(7-azaoxindol-3-yl)-6-methoxy-7-(3-moφholinopropoxy)quinazoline, 4-(7-azaoxindol-3-yl)-7-(2-(imidazol-l-yl)ethoxy)-6-methoxyquinazoline, 4-(5,7-diaza-6-methyloxindol-3-yl)-7-(3-moφholinopropoxy)quinazoline and 4-(4-aza-6-trifluorornethyloxindol-3-yl) 6-methoxy-7-(3-moφholinopropoxy)quinazoline and salts thereof, particularly hydrochloride salts thereof. Additional more preferred compounds are 4-(5,7-diaza-6-methyloxindol-3-yl)-7-(3-(l,l-dioxothiomoφholino)propoxy)quinazoline, 4-(7-aza-6-chlorooxindol-3-yl)-7-(3-moφholinopropoxy)quinazoline, 4-(7-azaoxindol-3-yl)-7-(4-moφholinobut-2-en- 1 -yloxy)quinazoline and 4-(5,7-diaza-6-methyloxindol-3-yl)-7-(3-methylsulphonylpropoxy)quinazoline and salts thereof, particularly hydrochloride salts thereof. In a particular aspect of the invention a preferred compound is 4-(5,7-diaza-6-methyloxindol-3-yl)-7-(3-moφholinopropoxy)quinazoline and salts thereof, particularly hydrochloride salts thereof. In a further particular aspect of the invention preferred compounds are 4-(7-azaoxindol-3-yl)-7-(2-(2-methoxyethoxy)ethoxy)quinazoline and 4-(7-azaoxindol-3-yl)-7-(3-moφholinopropoxy)quinazoline and salts thereof, particularly hydrochloride salts thereof. For the avoidance of doubt it is to be understood that where in this specification a group is qualified by 'hereinbefore defined' or 'defined hereinbefore' the said group encompasses the first occurring and broadest definition as well as each and all of the preferred definitions for that group. In this specification unless stated otherwise the term "alkyl" includes both straight and branched chain alkyl groups but references to individual alkyl groups such as "propyl" are specific for the straight chain version only. An analogous convention applies to other generic terms. Unless otherwise stated the term "alkyl" advantageously refers to chains with 1-6 carbon atoms, preferably 1-4 carbon atoms. The term "alkoxy" as used herein, unless stated otherwise includes "alkyl"-O- groups in which "alkyl" is as hereinbefore defined. The term "aryl" as used herein unless stated otherwise includes reference to a Cβ-io aryl group which may, if desired, carry one or more substituents selected from halogeno, alkyl, alkoxy, nitro, trifluoromethyl and cyano, (wherein alkyl and alkoxy are as hereinbefore defined). The term "aryloxy" as used herein unless otherwise stated includes "aryl"-O-groups in which "aryl" is as hereinbefore defined. The term "sulphonyloxy" as used herein refers to alkylsulphonyloxy and arylsulphonyloxy groups in which "alkyl" and "aryl" are as hereinbefore defined. The term "alkanoyl" as used herein unless otherwise stated includes formyl and alkylC=O groups in which "alkyl" is as defined hereinbefore, for example C 2 alkanoyl is ethanoyl and refers to CH 3 C=O, Ci alkanoyl is formyl and refers to CHO. In this specification unless stated otherwise the term "alkenyl" includes both straight and branched chain alkenyl groups but references to individual alkenyl groups such as 2-butenyl are specific for the straight chain version only. Unless otherwise stated the term "alkenyl" advantageously refers to chains with 2-5 carbon atoms, preferably 3-4 carbon atoms. In this specification unless stated otherwise the term "alkynyl" includes both straight and branched chain alkynyl groups but references to individual alkynyl groups such as 2-butynyl are specific for the straight chain version only. Unless otherwise stated the term "alkynyl" advantageously refers to chains with 2-5 carbon atoms, preferably 3-4 carbon atoms. Within the present invention it is to be understood that a compound of the formula I or a salt thereof may exhibit the phenomenon of tautomerism and that the formulae drawings within this specification can represent only one of the possible tautomeric forms. It is to be understood that the invention encompasses any tautomeric form which inhibits VEGF receptor tyrosine kinase activity and which inhibits FGF Rl receptor tyrosine kinase activity and is not to be limited merely to any one tautomeric form utilised within the formulae drawings. In particular the heteroaromatic oxindole group can exist in at least two forms giving compounds of formulae I and II: (wherein R 1 , R 2 , R 3 , ring Z, m and n are as hereinbefore defined). The formulae drawings within this specification can represent only one of the possible tautomeric forms and it is to be understood that the specification encompasses all possible tautomeric forms of the compounds drawn not just those forms which it has been possible to show graphically herein. It is also to be understood that certain compounds of the formula I and salts thereof can exist in solvated as well as unsolvated forms such as, for example, hydrated forms. It is to be understood that the invention encompasses all such solvated forms which inhibit VEGF receptor tyrosine kinase activity and inhibit FGF Rl receptor tyrosine kinase activity. For the avoidance of any doubt, it is to be understood that when X 7 is, for example, a group of formula -NR 16 CO-, it is the nitrogen atom bearing the R 16 group which is attached to the quinazoline ring and the carbonyl (CO) group is attached to R 15 , whereas when X 7 is, for example, a group of formula -CONR 17 -, it is the carbonyl group which is attached to the quinazoline ring and the nitrogen atom bearing the R 17 group is attached to R 15 . A similar convention applies to the other two atom X 7 linking groups such as -NR 19 SO 2 - and -SO 2 NR 18 - . When X 7 is -NR 20 - it is the nitrogen atom bearing the R 20 group which is linked to the quinazoline ring and to R 15 . An analogous convention applies to other groups. It is further to be understood that when X 7 represents -NR 20 - and R 20 is Cι -3 alkoxyC2 -3 alkyl it is the C 2-3 alkyl moiety which is linked to the nitrogen atom of X and an analogous convention applies to other groups. For the avoidance of any doubt, it is to be understood that in a compound of the formula I when R 15 is, for example, a group of formula Cι. 5 alkylX 15 Cι. 5 alkylR 39 , it is the terminal d-salkyl moiety which is linked to X 15 , similarly when R 15 is, for example, a group of formula C 2- salkenylR 39 it is the d-salkenyl moiety which is linked to X 7 and an analogous convention applies to other groups. When R 15 is a group l-R 39 prop-l-en-3-yl it is the first carbon to which the group R 39 is attached and it is the third carbon which is linked to X 7 and an analogous convention applies to other groups. For the avoidance of any doubt, it is to be understood that when R 39 carries a d. 4 aminoalkyl substituent it is the C 1-4 alkyl moiety which is attached to R 39 whereas when R 39 carries a Cι -4 alkylamino substituent it is the amino moiety which is attached to R 39 and an analogous convention applies to other groups. For the avoidance of any doubt when X 1 is d^alkanoyl it is the carbonyl moiety which is linked to the heteroaromatic oxindole group and it is the alkyl moiety which is linked to R 4 and an analogous convention applies to other groups. For the avoidance of any doubt when R 2 is a group X 2 C 2 - 4 alkylX 3 Cι -3 alkyl it is X 2 which is linked to the heteroaromatic oxindole group and an analogous convention applies to other groups. When R 2 is a group Cι-2alkylX 4 C2 -3 alkylX 5 Cι -3 alkyl it is the Cι -2 alkyl moiety which is linked to the heteroaromatic oxindole group and an analogous convention applies to other groups. The present invention relates to the compounds of formula I as hereinbefore defined as well as to the salts thereof. Salts for use in pharmaceutical compositions will be pharmaceutically acceptable salts, but other salts may be useful in the production of the compounds of formula I and their pharmaceutically acceptable salts. Pharmaceutically acceptable salts of the invention may, for example, include acid addition salts of the compounds of formula I as hereinbefore defined which are sufficiently basic to form such salts. Such acid addition salts include for example salts with inorganic or organic acids affording pharmaceutically acceptable anions such as with hydrogen halides (especially hydrochloric or hydrobromic acid of which hydrochloric acid is particularly preferred) or with sulphuric or phosphoric acid, or with trifluoroacetic, citric or maleic acid. In addition where the compounds of formula I are sufficiently acidic, pharmaceutically acceptable salts may be formed with an inorganic or organic base which affords a pharmaceutically acceptable cation. Such salts with inorganic or organic bases include for example an alkali metal salt, such as a sodium or potassium salt, an alkaline earth metal salt such as a calcium or magnesium salt, an ammonium salt or for example a salt with methylamine, dimethylamine, trimethylamine, piperidine, moφholine or tris-(2-hydroxyethyl)amine. A compound of the formula I, or salt thereof, and other compounds of the invention (as hereinafter defined) may be prepared by any process known to be applicable to the preparation of chemically-related compounds. Such processes include, for example, those illustrated in European Patent Applications Publication Nos. 0520722, 0566226, 0602851, 0635498 and 0636608. Such processes also include, for example, solid phase synthesis. Such processes, are provided as a further feature of the invention and are as described hereinafter. Necessary starting materials may be obtained by standard procedures of organic chemistry. The preparation of such starting materials is described within the accompanying non-limiting Examples. Alternatively necessary starting materials are obtainable by analogous procedures to those illustrated which are within the ordinary skill of an organic chemist. Thus the following processes (a) to (h) and (i) to (viii) constitute further features of the present invention. Synthesis of Compounds of Formula I (a) Compounds of the formula I and salts thereof may be prepared by the reaction of a compound of the formula III: ( ΠD (wherein R and m are as defined hereinbefore and L is a displaceable moiety), with a compound of the formula IV: (IV) (wherein R 1 , R 2 ring Z and n are as defined hereinbefore) whereby to obtain compounds of the formula I and salts thereof. A convenient displaceable moiety L 1 is, for example, a halogeno, alkoxy (preferably aryloxy, alkylthio, arylthio, alkoxyalkylthio or sulphonyloxy group, for example a chloro, bromo, methoxy, phenoxy, methylthio, 2-methoxyethylthio, methanesulphonyloxy or toluene-4-sulphonyloxy group. The reaction is advantageously effected in the presence of a base. Such a base is, for example, an organic amine base such as, for example, pyridine, 2,6-lutidine, collidine, 4-dimethylaminopyridine, triethylamine, moφholine, N-methylmoφholine or diazabicyclo[5.4.0]undec-7-ene, tetramethylguanidine or for example, an alkali metal or alkaline earth metal carbonate or hydroxide, for example sodium carbonate, potassium carbonate, calcium carbonate, sodium hydroxide or potassium hydroxide. Alternatively such a base is, for example, an alkali metal hydride, for example sodium hydride, or an alkali metal or alkaline earth metal amide, for example sodium amide, sodium bis(trimethylsilyl)amide, potassium amide or potassium bis(trimethylsilyl)amide. The reaction is preferably effected in the presence of an inert solvent or diluent, for example an ether such as tetrahydrofuran or 1,4-dioxan, an aromatic hydrocarbon solvent such as toluene, or a dipolar aprotic solvent such as N,N-dimethylformamide, N,N-dimethylacetamide, N-methylpyrrolidin-2-one or dimethyl sulphoxide. The reaction is conveniently effected at a temperature in the range, for example, 10 to 150°C, preferably in the range 20 to 90°C. When it is desired to obtain the acid salt, the free base may be treated with an acid such as a hydrogen halide, for example hydrogen chloride, sulphuric acid, a sulphonic acid, for example methane sulphonic acid, or a carboxylic acid, for example acetic or citric acid, using a conventional procedure. (b) A compound of the formula I and salts thereof can be prepared by the deprotection of a compound of formula V: (V) (wherein R 2 , R 3 , n, ring Z and m are as hereinbefore defined and P 1 represents a protecting group). The choice of indole protecting group P 1 is within the standard knowledge of an organic chemist, for example those included in standard texts such as "Protective Groups in Organic Synthesis" T.W. Greene and R.G.M.Wuts, 2nd Ed. Wiley 1991 , including N-sulphonyl derivatives (for example, p-toluenesulphonyl), carbamates (for example, t-butyl carbonyl), N- alkyl derivatives (for example, 2-chloroethyl, benzyl) and particularly amino acetal derivatives (for example, diethoxymethyl and benzyloxy methyl). The removal of such a protecting group may be effected by any of the procedures known for such a transformation, including those reaction conditions indicated in standard texts such as that indicated hereinbefore, or by a related procedure. For example, where the protecting group P 1 is diethoxymethyl, the transformation may conveniently be effected by treatment of the heteroaromatic oxindole derivative with an acid (as defined hereinbefore in process (a)) preferably in the presence of a protic solvent or co-solvent such as water or an alcohol, for example methanol or ethanol. Such a reaction can be effected in the presence of an additional inert solvent or diluent (as defined hereinbefore in process (a)) advantageously at a temperature in the range 0 to 100°C, conveniently in the range 20 to 90°C. (c) Compounds of the formula I and salts thereof wherein R 1 is hydrogen may also be prepared by the reduction and cyclisation of a compound of formula VI: (VI) (wherein R 2 , R 3 , m, ring Z and n are as defined hereinbefore and Y represents cyano, carboxy or Cι -4 alkoxycarbonyl). The reduction of the nitro group may conveniently be effected as described in process (i) hereinafter. Where Y represents carboxy or Cι -4 alkoxycarbonyl, the cyclisation to a compound of formula I occurs spontaneously after reduction of the nitro group or may be promoted, if necessary, by heating in an inert solvent or diluent such as xylene, toluene or N,N-dimethylformamide, optionally in the presence of an acid (as described hereinbefore in process (a)), advantageously at a temperature in the range of 20 to 150°C preferably in the range 20 to 100°C. Where Y represents cyano, the cyclisation to a compound of formula I can be effected in the presence of an acid (as described hereinbefore in process (a)) or a Lewis acid, such as a haloborane derivative for example boron trifluoride, and an alcohol or thiol, such as methanol, ethanol or 2-methyl-2-propanethiol, in an inert solvent or diluent (as defined hereinbefore in process (a)) and at a temperature in the range -20 to 50°C preferably -5 to 10°C, followed by treatment with an aqueous acid, (as defined hereinbefore in process (a)), at a temperature in the range 20 to 150°C preferably in the range 20 to 100°C. (d) Compounds of formula I and salts thereof wherein at least one of the R 2 groups is hydroxy may also be prepared by the deprotection of a compound of formula VII: (vπ) (wherein R 1 , R 2 , R 3 , n, ring Z and m are as defined hereinbefore, P 2 represents a phenolic hydroxy protecting group and pi is an integer from 1 to 3 equal to the number of protected hydroxy groups and such that n-pl is equal to the number of R substituents which are not protected hydroxy). The choice of phenolic hydroxy protecting group P 2 is within the standard knowledge of an organic chemist, for example those included in standard texts such as "Protective Groups in Organic Synthesis" T.W. Greene and R.G.M.Wuts, 2nd Ed. Wiley 1991, including ethers (for example, methyl, methoxymethyl, allyl, benzyl and benzyl substituted with up to 2 substituents selected from Cι- alkoxy and nitro), silyl ethers (for example, t-butyldiphenylsilyl and t-butyldimethylsilyl), esters (for example, acetate and benzoate) and carbonates (for example, methyl, benzyl and benzyl substituted with up to 2 substituents selected from Cι- alkoxy and nitro). The removal of such a phenolic hydroxy protecting group may be effected by any of the procedures known for such a transformation, including those reaction conditions indicated in standard texts such as that indicated hereinbefore, or by a related procedure. For example, where the protecting group P 2 is benzyl, the transformation may conveniently be effected by treatment of the heteroaromatic oxindole derivative with an acid (as defined hereinbefore in process (a)) particularly trifluoroacetic acid, preferably in the presence of an ether or thioether such as thioanisole. Such a reaction can be effected in the presence of an additional inert solvent or diluent (as defined hereinbefore in process (a)) advantageously at a temperature in the range 0 to 80°C, conveniently at about 40°C. (e) Production of those compounds of formula I and salts thereof wherein at least one R 3 is R 15 X 7 wherein R 15 is as defined hereinbefore and X 7 is -O-, -S-, -SO 2 -, -CONR 17 -, - SO 2 NR 18 - or -NR 20 - (wherein R 17 , R 18 and R 20 each independently represents hydrogen, d. 3 alkyl or Cι -3 alkoxyC 2-3 alkyl) can be achieved by the reaction, conveniently in the presence of a base (as defined hereinbefore in process (a)) of a compound of the formula VIII: (VΠD (wherein R 1 , R 2 , R 3 , n, ring Z and X 7 are as hereinbefore defined and s is an integer from 0 to 3) with a compound of formula IX: R 15 -L' (IX) (wherein R 15 and L 1 are as hereinbefore defined), L 1 is a displaceable moiety for example a halogeno or sulphonyloxy group such as a bromo, methanesulphonyloxy or toluene-4- sulphonyloxy group, or L 1 may be generated in situ from an alcohol under standard Mitsunobu conditions ("Organic Reactions", John Wiley & Sons Inc, 1992, vol 42, chapter 2, David L Hughes). The reaction is preferably effected in the presence of a base (as defined hereinbefore in process (a)) and advantageously in the presence of an inert solvent or diluent (as defined hereinbefore in process (a)), advantageously at a temperature in the range, for example 10 to 150°C, conveniently at about 50°C. (f) Compounds of the formula I and salts thereof wherein at least one R 3 is R 15 X 7 wherein R 15 is as defined hereinbefore and X 7 is -O-, -S-, or -NR 20 - (wherein R 20 represents hydrogen, Qι -3 alkyl or Cι -3 alkoxyC 2-3 alkyl) may be prepared by the reaction of a compound of the formula X: (X) with a compound of the formula XI: R 15 -X 7 -H (XI) (wherein L 1 , R 1 , R 2 , R 3 , R 15 , n, ring Z, s and X 7 are all as hereinbefore defined). The reaction may conveniently be effected in the presence of a base (as defined hereinbefore in process (a)) and advantageously in the presence of an inert solvent or diluent (as defined hereinbefore in process (a)), advantageously at a temperature in the range, for example 10 to 150°C, conveniently at about 100°C. (g) Compounds of the formula I and salts thereof wherein at least one R 3 is R 15 X 7 wherein X 7 is as defined hereinbefore and R 15 is Cι -5 alkylR 70 , [wherein R 70 is selected from one of the following six groups: 1) X 16 C, -3 alkyl (wherein X 16 represents -O-, -S-, -SO 2 -, -NR 71 CO- or -NR 72 SO 2 - (wherein R 71 and R 72 which may be the same or different are each hydrogen, Cι -3 alkyl or Cι. 3 alkoxyC 2- 3 alkyl); 2) NR 73 R 74 (wherein R 73 and R 74 which may be the same or different are each hydrogen, Ci- 3 alkyl or C i -3 alkoxyC 2-3 alkyl) ; 3) X 17 Cι -5 alkylX π R 32 (wherein X 17 represents -O-, -S-, -SO 2 -, -NR 75 CO-, -NR 76 SO 2 - or - NR 77 - (wherein R 75 , R 76 , and R 77 which may be the same or different are each hydrogen, d. 3 alkyl or d -3 alkoxyC 2-3 alkyl) and X 11 and R 32 are as defined hereinbefore); 4) R 65 (wherein R 65 is as defined hereinbefore); 5) X 18 R 39 (wherein X 18 represents -O-, -S-, -SO 2 -, -NR 78 CO-, -NR 79 SO 2 -, or -NR 80 - (wherein R 78 , R 79 , and R 80 which may be the same or different are each hydrogen, Cι -3 alkyl or d. 3 alkoxyC 2-3 alkyl) and R 39 is as defined hereinbefore); and 6) X 19 Cι. 5 alkylR 39 (wherein X 19 represents -O-, -S-, -SO 2 -, -NR 81 CO-, -NR 82 SO 2 - or -NR 83 - (wherein R 81 , R 82 and R 83 each independently represents hydrogen, Cι -3 alkyl or Cι -3 alkoxyC 2- 3 alkyl) and R 39 is as defined hereinbefore);] may be prepared by reacting a compound of the formula XII: (XII) (wherein L 1 , v X7 , R , R , R , n, ring Z and s are as hereinbefore defined) with a compound of the formula XTJI: (wherein R 70 is as defined hereinbefore) to give a compound of the formula I or salt thereof. The reaction may conveniently be effected in the presence of a base (as defined hereinbefore in process (a)) and advantageously in the presence of an inert solvent or diluent (as defined hereinbefore in process (a)), and at a temperature in the range, for example 0 to 150°C, conveniently at about 50°C. Processes (a)-(d) are preferred over processes (e)-(g). (h) The production of those compounds of the formula I and salts thereof wherein one or more of the substituents (R 3 ) m is represented by -NR 84 R 85 -, where one or both of R 84 and R 85 are Cι -3 alkyl, may be effected by the reaction of compounds of formula I wherein the substituent (R 3 ) m is an amino group and an alkylating agent, preferably in the presence of a base as defined hereinbefore. Such alkylating agents are Cι. 3 alkyl moieties bearing a displaceable moiety as defined hereinbefore such as C 1-3 alkyl halides for example Cι -3 alkyl chloride, bromide or iodide. The reaction is preferably effected in the presence of an inert solvent or diluent (as defined hereinbefore in process (a)) and at a temperature in the range, for example, 10 to 100°C, conveniently at about ambient temperature. The production of compounds of formula I and salts thereof wherein one or more of the substituents R 2 or R 3 is an amino group may be effected by the reduction of a corresponding compound of formula I wherein the substituent(s) at the corresponding position(s) of the quinazoline and/or heteroaromatic oxindole group is/are a nitro group(s). The reduction may conveniently be effected as described in process (i) hereinafter. The production of a compound of formula I and salts thereof wherein the substituent(s) at the corresponding position(s) of the quinazoline and/or heteroaromatic oxindole group is/are a nitro group(s) may be effected by the processes described hereinbefore and hereinafter in processes (a-g, (preferably a, b or d-g, more preferably a, b or d)) and (i-viii) using a compound selected from the compounds of the formulae (I-XXXIV) in which the substituent(s) at the corresponding position(s) of the quinazoline and or benz ring of the heteroaromatic oxindole group is/are a nitro group(s). Synthesis of Intermediates (i) The compounds of formula III and salts thereof, constitute a further feature of the present invention. Such compounds in which L 1 is halogeno may for example be prepared by halogenating a compound of the formula XIV: (XIV) (wherein R and m are as hereinbefore defined). Convenient halogenating agents include inorganic acid halides, for example thionyl chloride, phosphorus(IU)criloride, phosphorus(V)oxychloride and phosphorus(V)chloride. The halogenation reaction may be effected in the presence of an inert solvent or diluent such as for example a halogenated solvent such as methylene chloride, trichloromethane or carbon tetrachloride, or an aromatic hydrocarbon solvent such as benzene or toluene, or the reaction may be effected without the presence of a solvent. The reaction is conveniently effected at a temperature in the range, for example 10 to 150°C, preferably in the range 40 to 100°C. The compounds of formula XIV and salts thereof which constitute a further feature of the present invention may for example be prepared by reacting a compound of the formula XV: (XV) (wherein R 3 , s and L 1 are as hereinbefore defined) with a compound of the formula XI as hereinbefore defined. The reaction may conveniently be effected in the presence of a base (as defined hereinbefore in process (a)) and advantageously in the presence of an inert solvent or diluent (as defined hereinbefore in process (a)), advantageously at a temperature in the range, for example 10 to 150°C, conveniently at about 100°C. Compounds of formula XIV and salts thereof wherein at least one R 3 is R 15 X 7 and wherein X 7 is -O-, -S-, -SO 2 -, -CONR 17 -, -SO 2 NR 18 - or -NR 20 - (wherein R 17 , R 18 and R 20 each independently represents hydrogen, Cι -3 alkyl or Cι -3 alkoxyC2 -3 alkyl), may for example also be prepared by the reaction of a compound of the formula XVI: (wherein R 3 , s and X 7 are as hereinbefore defined) with a compound of the formula DC as hereinbefore defined. The reaction may for example be effected as described for process (e) hereinbefore. The pivaloyloxymethyl group can then be cleaved by reacting the product with a base such as, for example, aqueous ammonia, triethylamine in water, an alkali metal or alkaline earth metal hydroxide or alkoxide, preferably aqueous ammonia, aqueous sodium hydroxide or aqueous potassium hydroxide, in a polar protic solvent such as an alcohol, for example methanol or ethanol. The reaction is conveniently effected at a temperature in the range 20 to 100°C, preferably in the range 20 to 50°C. The compounds of formula XIV and salts thereof may also be prepared by cyclising a compound of the formula XVII: (XVπ) (wherein R and m, are as hereinbefore defined, and A is an hydroxy, alkoxy (preferably d- 4 alkoxy) or amino group) whereby to form a compound of formula XIV or salt thereof. The cyclisation may be effected by reacting a compound of the formula XVII, where A 1 is an hydroxy or alkoxy group, with formamide or an equivalent thereof effective to cause cyclisation whereby a compound of formula XIV or salt thereof is obtained, such as [3- (dimethylamino)-2-azaprop-2-enylidene]dimethylammonium chloride. The cyclisation is conveniently effected in the presence of formamide as solvent or in the presence of an inert solvent or diluent such as an ether for example 1 ,4-dioxan. The cyclisation is conveniently effected at an elevated temperature, preferably in the range 80 to 200°C. The compounds of formula XIV may also be prepared by cyclising a compound of the formula XVII, where A 1 is an amino group, with formic acid or an equivalent thereof effective to cause cyclisation whereby a compound of formula XIV or salt thereof is obtained. Equivalents of formic acid effective to cause cyclisation include for example a tri-Cι -4 alkoxymethane, for example triethoxymethane and trimethoxymethane. The cyclisation is conveniently effected in the presence of a catalytic amount of an anhydrous acid, such as a sulphonic acid for example p- toluenesulphonic acid, and in the presence of an inert solvent or diluent such as for example a halogenated solvent such as methylene chloride, trichloromethane or carbon tetrachloride, an ether such as diethyl ether or tetrahydrofuran, or an aromatic hydrocarbon solvent such as toluene. The cyclisation is conveniently effected at a temperature in the range, for example 10 to 100°C, preferably in the range 20 to 50°C. Compounds of formula XVII and salts thereof, which constitute a further feature of the present invention, may for example be prepared by the reduction of the nitro group in a compound of the formula XVB1: (wherein R 3 , m and A 1 are as hereinbefore defined) to yield a compound of formula XVII as hereinbefore defined. The reduction of the nitro group may conveniently be effected by any of the procedures known for such a transformation. The reduction may be carried out, for example, by stirring a solution of the nitro compound under hydrogen at 1 to 4 atmospheres pressure in the presence of an inert solvent or diluent as defined hereinbefore in the presence of a metal effective to catalyse hydrogenation reactions such as palladium or platinum. A further reducing agent is, for example, an activated metal such as activated iron (produced for example by washing iron powder with a dilute solution of an acid such as hydrochloric acid). Thus, for example, the reduction may be effected by heating the nitro compound under hydrogen at 2 atmospheres pressure in the presence of the activated metal and a solvent or diluent such as a mixture of water and alcohol, for example methanol or ethanol, at a temperature in the range, for example 50 to 150°C, conveniently at about 70°C. Compounds of the formula XVIII and salts thereof which constitute a further feature of the present invention, may for example be prepared by the reaction of a compound of the formula XIX: (XIX) (wherein R 3 , s, L 1 and A 1 are as hereinbefore defined) with a compound of the formula XI as hereinbefore defined to give a compound of the formula XVIII. The reaction of the compounds of formulae XDC and XI is conveniently effected under conditions as described for process (f) hereinbefore. Compounds of formula XVITJ and salts thereof wherein at least one R 3 is R 15 X 7 and wherein X 7 is -O-, -S-, -SO 2 -, -CONR 17 -, -SO 2 NR 18 - or -NR 20 - (wherein R 17 , R 18 and R 20 each independently represents hydrogen, Cι -3 alkyl or d. 3 alkoxyC 2 . 3 alkyl), may for example also be prepared by the reaction of a compound of the formula XX: (XX) (wherein R 3 , s, A 1 and X 7 are as hereinbefore defined) with a compound of the formula IX as hereinbefore defined to yield a compound of formula XVIII as hereinbefore defined. The reaction of the compounds of formulae XX and IX is conveniently effected under conditions as described for process (e) hereinbefore. The compounds of formula III and salts thereof wherein at least one R 3 is R I5 X 7 and wherein X 7 is -O-, -S-, -SO 2 -, -CONR 17 -, -SO 2 NR 18 - or -NR 20 - (wherein R 17 , R 18 and R 20 each independently represents hydrogen, C| -3 alkyl or C|. 3 alkoxyC 2 . 3 alkyl), may also be prepared for example by reacting a compound of the formula XXI: (XXI) (wherein R 3 , X 7 and s are as hereinbefore defined, and L 2 represents a displaceable protecting moiety) with a compound of the formula DC as hereinbefore defined, whereby to obtain a compound of formula HJ in which L 1 is represented by L 2 . A compound of formula XXI is conveniently used in which L represents a phenoxy group which may if desired carry up to 5 substituents, preferably up to 2 substituents, selected from halogeno, nitro and cyano. The reaction may be conveniently effected under conditions as described for process (e) hereinbefore. The compounds of formula XXI and salts thereof which constitute a further feature of the present invention may for example be prepared by deprotecting a compound of the formula XXII: L 2 (XXII) (wherein R 3 , P 2 , X 7 , s and L 2 are as hereinbefore defined with the proviso that X 7 is not -CH 2 - ). Deprotection may be effected by techniques well known in the literature, for example where P 2 represents a benzyl group deprotection may be effected by hydrogenolysis or by treatment with trifluoroacetic acid. One compound of formula HI may if desired be converted into another compound of formula HI in which the moiety L 1 is different. Thus for example a compound of formula Ul in which L 1 is other than halogeno, for example optionally substituted phenoxy, may be converted to a compound of formula HI in which L 1 is halogeno by hydrolysis of a compound of formula III (in which L 1 is other than halogeno) to yield a compound of formula XIV as hereinbefore defined, followed by introduction of halide to the compound of formula XIV, thus obtained as hereinbefore defined, to yield a compound of formula III in which L 1 represents halogen. (ii) Compounds of formula IV and salts thereof which constitute a further feature of the present invention, may be prepared by any of the known procedures, references include: 'The Chemistry of Indoles" R. J. Sundberg page 341, 1970 Academic, New York; Gassman and Bergen, 1974, Jnl. Am. Chem. Soc, 96, 5508 and 5512; Quallich and Morrissey, 1993, Synthesis, 51; Cherest et al., 1989, Tetrahedron Letters, 30, 715; Marfat et al., 1987, Tetrahedron Letters, 28, 4027-4030; Robinson et al., 1991, J Org Chem 56, 4805; European Patent Application Publication number 0436333 A2; Daisley et al., Synth. Commun. 1981, 11(9), 743-749; Robinson et al., J Heterocyclic Chem 1996, 33, 287. In particular 5,7-diazaoxindoles may be made by a series of steps commencing with the reaction of a succinate diester with ethyl formate in the presence of a base. Such a base is for example an alkali metal hydride , for example sodium hydride, or an alkali metal or alkaline earth metal amide for example sodium amide, sodium bis(trimethylsilyl)amide, potassium amide or potassium bis(trimethylsilyl)amide, preferably sodium hydride. The reaction is preferably effected in the presence of an inert solvent or diluent (as defined hereinbefore in process (a)), such as benzene, xylene, toluene, preferably in toluene, and at a temperature in the range, for example, 25 to 100°C preferably in the range 25 to 80°C. The mixture is then reacted with an amidine, such as an alkylamidine, in an alcoholic solvent such as methanol, ethanol, 2-propanol, 2-pentanol, 2-methyl-l-propanol, preferably in 2-propanol. The reaction is conveniently effected at the temperature of reflux of the solvent. (Reference: Biggs, J Amer Chem Soc. 1959, 1849). Halogenation of the product is then conveniently effected under conditions as described in (i) hereinbefore. Displacement of the chlorine atom may be effected by reacting the product with an azide derivative such as sodium azide, trimethylsilyl azide, preferably sodium azide, in a dipolar aprotic solvent (as defined hereinbefore in process (a)), conveniently in N,N-dimethylformamide. The reaction may advantageously be effected at a temperature in the range 50 to 80°C. The resulting azide is then reduced by any of the procedures known for such a transformation. The reduction may be effected in a similar manner to that described in (i) hereinbefore. Thus for example, the reduction may be effected by stirring the azide in the presence of 10% palladium-on-charcoal catalyst under hydrogen at atmospheric pressure in the presence of a solvent or diluent such as an alcohol, for example methanol, ethanol or N,N-dimethylformamide, at a temperature in the range 15 to 50°C preferably at ambient temperature. Cyclisation may then be achieved by heating the product in an inert solvent such as toluene, xylene, diphenyl ether, Dowtherm (trade mark of Fluka Chemie AG) mixture, preferably diphenyl ether or Dowtherm mixture. The cyclisation may conveniently be effected at a temperature in the range, for example, 100 to 250°C preferably in the range 150 to 200°C. Alternatively (after Seela et. al., Liebgs Ann. Chem. 1984, 275-282 and Seela et. al., Helvetica Chimica Acta 1994, 77, 194) 5,7-diazaoxindoles may also be made by reacting a compound of formula ZI : (ZI) (wherein R 86 represents Cι -3 alkyl, or any of the values of R 4 (wherein R 4 is as defined hereinbefore)), with ethyl 2-cyano-4,4-diethoxybutylcarboxylate. The reaction is conveniently done in the presence of a base such as an alkali metal or alkaline earth metal alkoxide, for example sodium methoxide, sodium ethoxide, potassium methoxide or potassium ethoxide. The reaction is preferably effected in the presence of a solvent such as an alcohol conveniently methanol, ethanol, advantageously the alcohol corresponding to the R 86 substituent, for example if R 86 is methoxy the solvent is advantageously methanol. The reaction is conveniently effected at a temperature in the range, for example, 50 to 200°C, preferably in the range 50 to 150°C. The resulting azide may then be treated with an inorganic acid such as hydrochloric acid or sulphuric acid to give an azaindole. Halogenation of the azaindole may then be effected with a halogenating agent (as described in (i) hereinbefore) in an inert solvent or diluent, in an aromatic hydrocarbon solvent or in an aromatic amine, for example the reaction may advantageously be effected in methylene chloride, trichloromethane, benzene, toluene, N,N-dimethylaniline, N,N-diethylaniline, more preferably in N,N-dimethylaniline. The reaction is conveniently effected at a temperature in the range, for example, 50 to 200°C preferably in the range 80 to 150°C. The azaindole may then be reduced under similar conditions to those described in (i) hereinbefore for the reduction of a nitro group. For example, the reduction may be achieved by stirring a solution of the azaindole under hydrogen at atmospheric pressure in the presence of 10% palladium-on-charcoal catalyst in the presence of a solvent such as an alcohol, methanol or ethanol, containing an amine such as triethylamine, ethylamine or ammonia, preferably containing ammonia, conveniently at a temperature in the range 15 to 80°C, preferably at ambient temperature. Bromination of the resulting azaindole may then conveniently be effected by treating the azaindole with pyridinium bromide perbromide in a protic solvent such as an alcohol, for example, 2-methyl- 2-propanol at a temperature in the range 25 to 75°C, preferaby in the range 25 to 45°C. Reduction of the product is then effected, in a similar manner to that described in (i) hereinbefore. For example, the reduction may conveniently be effected by stirring a solution of the product under hydrogen at atmospheric pressure in the presence of an inert solvent or diluent such as methanol, ethanol or N,N-dimethylformamide, in the presence of 10% palladium-on-charcoal catalyst. Alternatively (after Yamanaka et. al., Chem. Pharm. Bull. 1993, 41, 81-86) 5,7- diazaoxindoles may also be made by reacting a compound of formula Z2: (Z2) (wherein R 87 represents hydrogen, Cι -5 alkyl, Cj.salkoxy or any of the values of R 2 as defined hereinbefore with the exception of hydroxy, amino, C 2-4 alkanoyl and Cι.4alkylsulphinyl, R 88 represents bromo or iodo and R 89 represents d -5 alkyl or phenyl), with a trialkylstannane, preferably a tributylstannane, such as (2-ethoxy vinyl)tributyltin, in the presence of a palladium salt, preferably dichlorobis(triphenylphosphine)palladium, in the presence of an ammonium salt such as tetraethylammonium chloride. The reaction may be effected in a dipolar aprotic solvent (as defined hereinbefore in process (a)) such as N,N-dimethylformamide, acetonitrile or tetrahydrofuran, preferably in N,N-dimethylformamide or acetonitrile. The reaction is conveniently done at a temperature in the range 50 to 200°C more preferably in the range 80 to 150°C. Cyclisation of the product may be effected by heating it in a polar protic solvent such as an alcohol, preferaby methanol or ethanol, in the presence of an inorganic acid such as hydrochloric, hydrobromic or sulphuric acid. The reaction may conveniently be effected at a temperature in the range 50 to 200°C, preferably in the range 50 to 150°C. Bromination of the resulting azaindole may then conveniently be effected as described hereinbefore. Reduction of the product is then effected in a similar manner to that described in (i) hereinbefore. For example, the reduction may conveniently be effected by stirring a solution of the product under hydrogen at atmospheric pressure in the presence of an inert solvent or diluent such as methanol, ethanol or N,N-dimethylformamide, in the presence of 10% palladium-on-charcoal catalyst. 4,6-Diazaoxindoles (after Yamanaka, Chem. Pharm. Bull. 1993, 41, 81-86) may be made by reacting a compound of formula Z3 : (Z3) (wherein R 90 represents hydrogen, Ci.salkyl, Cι -5 alkoxy or any of the values of R 2 as defined hereinbefore with the exception of hydroxy, amino, C 2- 4alkanoyl, and and R 91 represents bromo or iodo) with a trialkylstannane, preferably a tributylstannane, such as (2-ethoxy vinyl)tributyltin, in the presence of a palladium salt, preferably dichlorobis(triphenylphosphine)palladium, in the presence of an ammonium salt such as tetraethylammonium chloride. The reaction may conveniently be effected in a dipolar aprotic solvent (as defined hereinbefore in process (a)), such as N,N-dimethylformamide, acetonitrile or tetrahydrofuran, preferably in N,N-dimethylformamide, or acetonitrile. The reaction is advantageously done at a temperature in the range 50 to 200°C more preferably in the range 80 to 150°C. The reduction of the nitro group in the resulting product may be achieved under similar conditions to those described in (i) hereinbefore. For example the reaction is conveniently effected by stirring the product under hydrogen at atmospheric pressure in the presence of a polar solvent such as methanol, ethanol or a mixture of an alcohol and a chlorinated solvent such as methylene chloride, in the presence of an activated metal catalyst such as Raney nickel. The reaction may conveniently be effected at a temperature in the range 15 to 80°C more preferably at ambient temperature. Cyclisation of the product may be effected by heating a solution of the product in an alcohol, such as methanol or ethanol, containing inorganic acid, for example, aqueous hydrochloric, hydrobromic or sulphuric acid, at a temperature in the range 50 to 150°C, more preferably at the temperature of reflux of the solvent. The reaction may conveniently be effected at the same time as the reduction of the nitro group and without isolation of the intermediate product. Bromination of the resulting azaindole may then conveniently be effected as described hereinbefore. Reduction of the product is then effected in a similar manner to that described in (i) hereinbefore. For example, the reduction may conveniently be effected by stirring a solution of the product under hydrogen at atmospheric pressure in the presence of an inert solvent or diluent such as methanol, ethanol or N,N-dimethylformamide, in the presence of 10% palladium-on-charcoal catalyst. 5,6-Diazaoxindoles (after Marquet et. el., Chimie Therapeutique 1968, 3, 348), may be prepared by reacting a compound of the formula Z4: (Z4) (wherein R 92 represents Ci-salkoxy, halo, amino, Ci-salkylamino, di(Cι -5 alkyl)amino or arylamino, preferably Ci.salkoxy, especially ethoxy) with hydrazine. The reaction may conveniently be effected in a polar protic solvent such as methanol, ethanol, 2-propanol, 3- methyl-1-butanol, preferably in ethanol, at a temperature in the range 50 to 120°C, preferably at the temperature of reflux of the solvent. Halogenation of the product may then be effected by reacting the product with a halogenating agent (as described in (i) hereinbefore). The reaction is conveniently effected without a solvent or in the presence of an inert solvent or diluent such as, for example, a halogenated solvent such as methylene chloride, trichloromethane or carbon tetrachloride, or an aromatic hydrocarbon solvent such as benzene or toluene. The reaction may conveniently be effected at a temperature in the range, for example 10 to 150°C, preferably in the range 40 to 100°C. The resulting azaindole may then be reduced in a similar manner to that described in (i) hereinbefore. The reaction may conveniently be effected in the presence of a base such as an alkali metal or alkaline earth metal alkoxide, for example, sodium ethoxide or sodium methoxide. For example, the reduction may be achieved by heating a solution of the azaindole under hydrogen at 2 atmospheres pressure in the presence of 10% palladium-on-charcoal catalyst in ethanol containing sodium hydroxide, conveniently at a temperature in the range 15 to 80°C, preferably at ambient temperature. Bromination of the resulting azaindole may then conveniently be effected as described hereinbefore. Reduction of the product is then effected in a similar manner to that described in (i) hereinbefore. For example, the reduction may conveniently be effected by stirring a solution of the product under hydrogen at atmospheric pressure in the presence of an inert solvent or diluent such as methanol, ethanol or N,N- dimethylformamide, in the presence of 10% palladium-on-charcoal catalyst. 4,7-Diazaoxindoles may be prepared (after Parrick et al, J. Chem. Soc. Perk 1 1976, 1361) by reacting a compound of the formula Z5: (Z5) (wherein R 93 represents hydrogen, Ci-salkyl, Ci.salkoxy or any of the values for R 2 as defined hereinbefore with the exception of hydroxy, amino and C 2- 4alkanoyl) with an orthoformate such as methyl orthoformate or ethyl orthoformate, in the presence of a protic solvent such as an alcohol, for example, methanol, 1-propanol, 2-propanol, preferably methanol. The reaction may conveniently be effected in the presence of an inorganic acid such as hydrochloric, hydrobromic or sulphuric acid. The reaction may conveniently be effected at a temperature in the range 50 to 180°C, preferably in the range 50 to 150°C. The product is then heated in the presence of an amine or alkylaniline such as dimethylamine, diethylamine, methylaniline, ethylaniline, preferably methylaniline. The reaction may conveniently be effected at a temperature in the range 100 to 200°C, preferably in the range 150 to 180°C. The product is then reacted with an alkali metal amide or alkaline earth metal amide such as sodium amide or lithium amide, preferably sodium amide, in the presence of an alkylaniline such as methylaniline, ethylaniline, preferably methylaniline. The reaction may conveniently be effected at a temperature in the range 50 to 200°C, preferably in the range 50 to 150°C. Bromination of the resulting azaindole may then conveniently be effected as described hereinbefore. Reduction of the product is then effected in a similar manner to that described in (i) hereinbefore. For example, the reduction may conveniently be effected by stirring a solution of the product under hydrogen at atmospheric pressure in the presence of an inert solvent or diluent such as methanol, ethanol or N,N-dimethylformamide, in the presence of 10% palladium-on-charcoal catalyst. 4,5-Diazaoxindoles may be prepared (after Parrick et al, J. Chem. Soc. Perk I, 1976, 1363 and P Cook et al, J. Het. Chem. 1973, 10, 807) by reacting a compound of formula Z6: (Z6) (wherein R >°4 . represents hydrogen, Ci-salkyl, Ci.salkoxy or any of the values fo .r_ r R2 as defined hereinbefore with the exception of hydroxy, amino and d^alkanoyl) with an orthoformate derivative such as methyl orthoformate or ethyl orthoformate in the presence of an inert solvent such as N,N-dimethylformamide, N,N-dimethylacetamide or l-methyl-2- pyrrolidinone, in the presence of a protic solvent such as an alcohol, for example methanol, 1- propanol, 2-propanol, advantageously methanol, preferably a mixture of N,N- dimethylformamide and methanol. The reaction may conveniently be effected in the presence of an inorganic acid such as hydrochloric, hydrobromic or sulphuric acid. The reaction may conveniently be effected at a temperature in the range 50 to 180°C, preferably in the range 50 to 150°C. The product may then be reacted with a potassium salt of diethyl or dimethyl oxalate. The reaction may conveniently be effected in a solvent or diluent such as ethanol, methanol, ether or tetrahydrofuran, preferably a mixture of ethanol and ether. The reaction may conveniently be effected at a temperature in the range 10 to 40°C preferably in the range 20 to 30°C. Cyclisation of the product may then be achieved by stirring the product in an aqueous solution of concentrated inorganic acid such as hydrochloric or hydrobromic acid at ambient temperature. The reduction of the nitrogen oxide group may then be effected by any procedure known in the literature to reduce nitrogen oxide, (Chemistry of Heterocyclic N- oxides, Katritsky and Lagowski, Academic Press 1971), such as reacting the product with phosphorus(Iϋ)chloride or phosphorus(V)chloride, in a chlorinated solvent such as methylene chloride or trichloromethane, or by reacting the product with trifluoroacetic anhydride in acetonitrile containing sodium iodide. The azaindole is then prepared by the reaction of the product with an aqueous solution of an inorganic base, such as sodium hydroxide, potassium hydroxide, in the presence of an inert solvent or diluent such as methanol, ethanol, preferably sodium hydroxide in a mixture of water and N,N-dimethylformamide or methanol. The reaction may conveniently by effected at a temperature in the range 25 to 100°C preferably in the range 25 to 50°C. The product is then treated with a solution of a concentrated or dilute inorganic acid such as hydrochloric, hydrobromic or sulphuric acid in the presence of an inert solvent such as methanol, ethanol, methylene chloride, preferably a mixture of water and ethanol. Bromination of the resulting azaindole may then conveniently be effected as described hereinbefore. Reduction of the product is then effected in a similar manner to that described in (i) hereinbefore. For example, the reduction may conveniently be effected by stirring a solution of the product under hydrogen at atmospheric pressure in the presence of an inert solvent or diluent such as methanol, ethanol or N,N-dimethylformamide, in the presence of 10% palladium-on-charcoal catalyst. In another aspect of the present invention 6,7-diazaoxindoles may be prepared by using a compound of formula Z7: (Z7) (wherein R 95 represents hydrogen, Chalky!, Ci.salkoxy or any of the values for R 2 as defined hereinbefore with the exception of hydroxy, amino and C 2-4 alkanoyl), instead of a compound of formula Z6 in the reactions described hereinbefore for the preparation of 4,5- diazaoxindoles. In another aspect of the present invention 5,6,7-triazaoxindoles may be prepared by reacting a compound of formula Z8: (Z8) (wherein R 96 represents hydrogen, Ci-salkyl, Ci.salkoxy methyl, di(Cι.salkoxy)methyl, aryl, benzyl, Ci.salkoxycarbonyl, di(Cι. 5 alkoxy)benzyl, preferably hydrogen, benzyl or Ci. 5 alkoxycarbonyl) with an inorganic acid such as polyphosphoric acid in phosphoric acid. The reaction may conveniendy be effected at a temperature in the range 50 to 150°C preferably in the range 100 to 150°C. The product may or may not be isolated before cyclisation. Cyclisation of the product may be effected by mixing a solution of the product in polyphosphoric acid with a solution of sodium nitrite. The reaction may conveniently be effected in a solvent such as water and at a temperature in the range -5 to 10°C, preferably 0°C. Halogenation of the cyclised product may then be effected with a halogenating agent, (as described in (i) hereinbefore), preferably with phosphorus(V)chloride. The reaction may conveniently be effected in an inert solvent or diluent such as for example methylene chloride, trichloromethane, in an aromatic hydrocarbon solvent such as for example benzene or toluene, or in an aromatic amine such as N,N-dimethylaniline, N,N-diethylaniline, more preferably N,N-dimethylaniline. The reaction is conveniently effected at a temperature in the range of 50 to 200°C more preferably in the range 80 to 150°C. The resulting halogenated azaindole may then be reduced in a similar manner to that described in (i) hereinbefore. For example, the reduction may conveniently be effected by stirring a solution of the azaindole under hydrogen at atmospheric pressure in the presence of a solvent such as an alcohol, for example, methanol or ethanol, containing an amine such as triethylamine, ethylamine or ammonia, preferably containing ammonia, in the presence of 10% palladium-on-charcoal catalyst at a temperature in the range 15 to 80°C, preferably at ambient temperature. Bromination of the resulting azaindole may then conveniently be effected as described hereinbefore. Reduction of the product is then effected in a similar manner to that described in (i) hereinbefore. For example, the reduction may conveniently be effected by stirring a solution of the product under hydrogen at atmospheric pressure in the presence of an inert solvent or diluent such as methanol, ethanol or N,N-dimethylformamide, in the presence of 10% palladium-on-charcoal catalyst. In another aspect of the present invention 4,5,6-triazaoxindoles may be prepared by using a compound of formula Z9: (Z9) (wherein R 97 represents hydrogen, Ci-salkyl, Ci.salkoxymethyl, di(Cι.salkoxy)methyl, aryl, benzyl, Ci.salkoxycarbonyl, di(Cι.salkoxy)benzyl, preferably hydrogen, benzyl or Cj. salkoxycarbonyl), instead of a compound of formula Z8 in the reactions described hereinbefore for the preparation of 5,6,7-triazaoxindoles. In the preparation of azaoxindoles, diazaoxindoles and triazaoxindoles, substituents on the heteroaromatic oxindole group may be added at any stage of the preparation by any process known to be appropriate for the puφose. (iii) The compounds of formula V and salts thereof, constitute a further feature of the present invention, and may for example be prepared by the reaction of a compound of formula III as hereinbefore defined with a compound of the formula XXIII: (XXIII) (wherein R 2 , n, ring Z and P 1 are as hereinbefore defined). The reaction may for example be effected as described for process (a) hereinbefore. The compounds of formula V and salts thereof may also be prepared by reacting a compound of formula XXIV: (XXIV) (wherein R 2 , R 3 , L 1 , n, ring Z, s and P 1 are as hereinbefore defined) with a compound of formula XI as hereinbefore defined. The reaction may for example be effected as described for process (f) above. The compounds of formula V and salts thereof wherein at least one R 3 is R 15 X 7 and wherein X 7 is -O-, -S-, -SO 2 -, -CONR 17 -, -SO 2 NR 18 - or -NR 20 - (wherein R 17 , R 18 and R 20 each independently represents hydrogen, Cι -3 alkyl or Cι -3 alkoxyC 2-3 alkyl), may also be prepared by reacting a compound of formula XXV: (XXV) (wherein R , R , X , n, ring Z, s and P are as hereinbefore defined) with a compound of the formula DC as hereinbefore defined. The reaction may for example be effected as described for process (e) hereinbefore. The compounds of formula XXIV and salts thereof constitute a further feature of the present invention and may for example be prepared by reaction of a compound of formula XXVI: (XXVI) (wherein R 3 , s and each L 1 are as hereinbefore defined, and the L 1 in the 4-position and the other L 1 in a further position on the quinazoline ring may be the same or different) with a compound of the formula XXIII as hereinbefore defined. The reaction may be effected for example by a process as described in (a) above. Compounds of the formula XXV and salts thereof which constitute a further feature of the present invention may be made by reacting compounds of the formulae XXII and XXIII as hereinbefore defined, under conditions described in (a) hereinbefore, to give a compound of formula XXVfl: (XXVII) (wherein R 2 , R 3 , P 1 , P 2 , X 7 , s, ring Z and n are as hereinbefore defined with the proviso that X 7 is not -CH 2 -) and then deprotecting the compound of formula XXVII for example as described in (i) above. (iv) Compounds of the formula VI and salts thereof constitue a further feature of the present invention and may be made by the reaction of a compound of formula III as hereinbefore defined with a compound of the formula XXVIII: (xxvπi) (wherein R 2 , n, ring Z and Y are as hereinbefore defined). The reaction may for example be effected as described for the process (a) hereinbefore. (v) The compounds of formula VII and salts thereof, constitute a further feature of the present invention, and may for example be prepared by the reaction of a compound of formula III as hereinbefore defined with a compound of the formula XXDC: (XXDC) (wherein R 1 , R 2 , n, pi, ring Z and P 2 are as hereinbefore defined). The reaction may for example be effected as described for process (a) hereinbefore. The compounds of formula VII and salts thereof may also be prepared by reacting a compound of formula XXX: (XXX) (wherein R 1 , R 2 , R 3 , L 1 , n, pi, s, ring Z and P are as hereinbefore defined) with a compound of formula XI as hereinbefore defined. The reaction may for example be effected as described for process (f) above. The compounds of formula VII and salts thereof wherein at least one R 3 is R 15 X 7 and wherein X 7 is -O-, -S-, -SO 2 -, -CONR 17 -, -SO 2 NR 18 - or -NR 20 - (wherein R 17 , R 18 and R 20 each independently represents hydrogen, Cι -3 alkyl or Cι. 3 alkoxyC 2-3 alkyl), may also be prepared by reacting a compound of formula XXXI: (XXXI) (wherein R 1 , R 2 , R 3 , X 7 , n, s, pi, ring Z and P are as hereinbefore defined) with a compound of the formula IX as hereinbefore defined. The reaction may for example be effected as described for process (e) hereinbefore. The compounds of formula XXX and salts thereof may for example be prepared by the reaction of a compound of formula XXVI as hereinbefore defined with a compound of the formula XXDC as hereinbefore defined. The reaction may be effected for example by a process as described in (a) above. Compounds of the formula XXXI and salts thereof may be made by reacting compounds of the formulae XXII and XXDC as hereinbefore defined, under conditions described in (a) hereinbefore, to give a compound of formula XXXII: (xxxπ) (wherein R 1 , R 2 , R 3 , P 2 , X 7 , pi, ring Z, n and s are as hereinbefore defined with the proviso that X 7 is not -CH 2 -) and then deprotecting the compound of formula XXXII for example as described in (i) above. (vi) Compounds of formula VIII as hereinbefore defined and salts thereof constitute a further feature of the present invention and may be made by deprotecting the compound of formula XXXfll: (XXXIII) (wherein R 1 , R 2 , R 3 , P 2 , X 7 , s, ring Z and n are as hereinbefore defined with the proviso that X 7 is not -CH 2 -) by a process for example as described in (i) above. Compounds of the formula XXXIII and salts thereof which constitute a further feature of the present invention may be made by reacting compounds of the formulae XXII and IV as hereinbefore defined, under the conditions described in (a) hereinbefore, to give a compound of the formula XXXIII or salt thereof. (vii) Compounds of the formula X and salts thereof constitute a further feature of the present invention and may be made by reacting compounds of the formulae XXVI and IV as hereinbefore defined, the reaction for example being effected by a process as described in (a) above. (viii) Compounds of formula XII as defined hereinbefore and salts thereof constitute a further feature of the present invention and may for example be made by the reaction of compounds of formula VIA as defined hereinbefore with compounds of the formula XXXIV: L'-d.salkyl-L 1 (XXXIV) (wherein L 1 is as hereinbefore defined) to give compounds of formula XII or salts thereof. The reaction may be effected for example by a process as described in (e) above. When a pharmaceutically acceptable salt of a compound of the formula I is required, it may be obtained, for example, by reaction of said compound with, for example, an acid using a conventional procedure, the acid having a pharmaceutically acceptable anion. Many of the intermediates defined herein are novel, for example, those of the formulae III, IV, V, VI, VII, VIII, X, XII, XIV, XV, XVI, XVII, XVIII, XIX, XX, XXI, XXII, XXm, XXIV, XXV, XXVI, XXVII, XXVIII, XXIX, XXX, XXXI, XXXII and XXXIII and these are provided as a further feature of the invention. The preparation of these compounds is as described herein and/or is by methods well known to persons skilled in the art of organic chemistry. The identification of compounds which potently inhibit the tyrosine kinase activity associated with VEGF receptors such as Fit and/or KDR and with FGF Rl receptors and which inhibit angiogenesis and/or increased vascular permeability is desirable and is the subject of the present invention. These properties may be assessed, for example, using one or more of the procedures set out below: (a) In Vitro Receptor Tyrosine Kinase Inhibition Test This assay determines the ability of a test compound to inhibit tyrosine kinase activity. DNA encoding VEGF, FGF or EGF receptor cytoplasmic domains may be obtained by total gene synthesis (Edwards M, International Biotechnology Lab 5(3), 19-25, 1987) or by cloning. These may then be expressed in a suitable expression system to obtain polypeptide with tyrosine kinase activity. For example VEGF, FGF and EGF receptor cytoplasmic domains, which were obtained by expression of recombinant protein in insect cells, were found to display intrinsic tyrosine kinase activity. In the case of the VEGF receptor Fit (Genbank accession number X51602), a 1.7kb DNA fragment encoding most of the cytoplasmic domain, commencing with methionine 783 and including the termination codon, described by Shibuya et al (Oncogene, 1990, 5: 519-524), was isolated from cDNA and cloned into a baculovirus transplacement vector (for example pAcYMl (see The Baculovirus Expression System: A Laboratory Guide, L.A. King and R. D. Possee, Chapman and Hall, 1992) or pAc360 or pBlueBacHis (available from Invitrogen Coφoration)). This recombinant construct was co-transfected into insect cells (for example Spodoptera frugiperda 21(Sf21)) with viral DNA (eg Phar ingen BaculoGold) to prepare recombinant baculovirus. (Details of the methods for the assembly of recombinant DNA molecules and the preparation and use of recombinant baculovirus can be found in standard texts for example Sambrook et al, 1989, Molecular cloning - A Laboratory Manual, 2nd edition, Cold Spring Harbour Laboratory Press and O'Reilly et al, 1992, Baculovirus Expression Vectors - A Laboratory Manual, W. H. Freeman and Co, New York). For other tyrosine kinases for use in assays, cytoplasmic fragments starting from methionine 806 (KDR, Genbank accession number L04947), methionine 668 (EGF receptor, Genbank accession number X00588) and methionine 399 (FGF Rl receptor, Genbank accession number X51803) may be cloned and expressed in a similar manner. For expression of cFlt tyrosine kinase activity, Sf21 cells were infected with plaque-pure cFlt recombinant virus at a multiplicity of infection of 3 and harvested 48 hours later. Harvested cells were washed with ice cold phosphate buffered saline solution (PBS) (lOmM sodium phosphate pH7.4, 138mM sodium chloride, 2.7mM potassium chloride) then resuspended in ice cold HNTG/PMSF (20mM Hepes pH7.5, 150mM sodium chloride, 10% v/v glycerol, 1% v/v Triton X100, 1.5mM magnesium chloride, ImM ethylene glycol- bis(βaminoethyl ether) N,N,N',N'-tetraacetic acid (EGTA), ImM PMSF (phenylmethylsulphonyl fluoride); the PMSF is added just before use from a freshly-prepared lOOmM solution in methanol) using 1ml HNTG/PMSF per 10 million cells. The suspension was centrifuged for 10 minutes at 13,000 φm at 4°C, the supernatant (enzyme stock) was removed and stored in aliquots at -70°C. Each new batch of stock enzyme was titrated in the assay by dilution with enzyme diluent (lOOmM Hepes pH 7.4, 0.2mM sodium orthovanadate, 0.1% v/v Triton X100, 0.2mM dithiothreitol). For a typical batch, stock enzyme is diluted 1 in 2000 with enzyme diluent and 50μl of dilute enzyme is used for each assay well. A stock of substrate solution was prepared from a random copolymer containing tyrosine, for example Poly (Glu, Ala, Tyr) 6:3:1 (Sigma P3899), stored as 1 mg/ml stock in PBS at -20°C and diluted 1 in 500 with PBS for plate coating. On the day before the assay lOOμl of diluted substrate solution was dispensed into all wells of assay plates (Nunc maxisoφ 96-well immunoplates) which were sealed and left overnight at 4°C. On the day of the assay the substrate solution was discarded and the assay plate wells were washed once with PBST (PBS containing 0.05% v/v Tween 20) and once with 50mM Hepes pH7.4. Test compounds were diluted with 10% dimethylsulphoxide (DMSO) and 25μl of diluted compound was transferred to wells in the washed assay plates. "Total" control wells contained 10% DMSO instead of compound. Twenty five microlitres of 40mM manganese(II)chloride containing 8μM adenosine-5'-triphosphate (ATP) was added to all test wells except "blank" control wells which contained manganese(II)chloride without ATP. To start the reactions 50μl of freshly diluted enzyme was added to each well and the plates were incubated at room temperature for 20 minutes. The liquid was then discarded and the wells were washed twice with PBST. One hundred microlitres of mouse IgG anti-phosphotyrosine antibody (Upstate Biotechnology Inc. product 05-321), diluted 1 in 6000 with PBST containing 0.5% w/v bovine serum albumin (BSA), was added to each well and the plates were incubated for 1 hour at room temperature before discarding the liquid and washing the wells twice with PBST. One hundred microlitres of horse radish peroxidase (HRP)-linked sheep anti-mouse Ig antibody (Amersham product NXA 931), diluted 1 in 500 with PBST containing 0.5% w/v BSA, was added and the plates were incubated for 1 hour at room temperature before discarding the liquid and washing the wells twice with PBST. One hundred microlitres of 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) solution, freshly prepared using one 50mg ABTS tablet (Boehringer 1204 521) in 50ml freshly prepared 50mM phosphate-citrate buffer pH5.0 + 0.03% sodium perborate (made with 1 phosphate citrate buffer with sodium perborate (PCSB) capsule (Sigma P4922) per 100ml distilled water), was added to each well. Plates were then incubated for 20-60 minutes at room temperature until the optical density value of the "total" control wells, measured at 405nm using a plate reading spectrophotometer, was approximately 1.0. "Blank" (no ATP) and "total" (no compound) control values were used to determine the dilution range of test compound which gave 50% inhibtion of enzyme activity. (b) In Vitro HUVEC Proliferation Assay This assay determines the ability of a test compound to inhibit the growth factor- stimulated proliferation of human umbilical vein endothelial cells (HUVEC). HUVEC cells were isolated in MCDB 131 (Gibco BRL) + 7.5% v/v foetal calf serum (FCS) and were plated out (at passage 2 to 8), in MCDB 131 + 2% v/v FCS + 3μg/ml heparin + 1 μg/ml hydrocortisone, at a concentration of 1000 cells/well in 96 well plates. After a minimum of 4 hours they were dosed with the appropriate growth factor (i.e. VEGF 3ng/ml, EGF 3ng/ml or b-FGF 0.3ng/ml) and compound. The cultures were then incubated for 4 days at 37°C with 7.5% CO 2 . On day 4 the cultures were pulsed with lμCi/well of tritiated-thymidine (Amersham product TRA 61) and incubated for 4 hours. The cells were harvested using a 96-well plate harvester (Tomtek) and then assayed for incoφoration of tritium with a Beta plate counter. Incoφoration of radioactivity into cells, expressed as cpm, was used to measure inhibition of growth factor-stimulated cell proliferation by compounds. (c) In Vivo Rat Uterine Oedema Assay This test measures the capacity of compounds to reduce the acute increase in uterine weight in rats which occurs in the first 4-6 hours following oestrogen stimulation. This early increase in uterine weight has long been known to be due to oedema caused by increased permeability of the uterine vasculature and recently Cullinan-Bove and Koos (Endocrinology, 1993,133:829-837) demonstrated a close temporal relationship with increased expression of VEGF mRNA in the uterus. We have found that prior treatment of the rats with a neutralising monoclonal antibody to VEGF significantly reduces the acute increase in uterine weight, confirming that the increase in weight is substantially mediated by VEGF. Groups of 20 to 22-day old rats were treated with a single subcutaneous dose of oestradiol benzoate (2.5μg/rat) in a solvent, or solvent only. The latter served as unstimulated controls. Test compounds were orally administered at various times prior to the administration of oestradiol benzoate. Five hours after the administration of oestradiol benzoate the rats were humanely sacrificed and their uteri were dissected, blotted and weighed. The increase in uterine weight in groups treated with test compound and oestradiol benzoate and with oestradiol benzoate alone was compared using a Student T test. Inhibition of the effect of oestradiol benzoate was considered significant when p<0.05. According to a further aspect of the invention there is provided a pharmaceutical composition which comprises a compound of the formula I as defined hereinbefore or a pharmaceutically acceptable salt thereof, in association with a pharmaceutically acceptable excipient or carrier. The composition may be in a form suitable for oral administration, for example as a tablet or capsule, for parenteral injection (including intravenous, subcutaneous, intramuscular, intravascular or infusion) for example as a sterile solution, suspension or emulsion, for topical administration for example as an ointment or cream or for rectal administration for example as a suppository. In general the above compositions may be prepared in a conventional manner using conventional excipients. The compositions of the present invention are advantageously presented in unit dosage form. The compound will normally be administered to a warm-blooded animal at a unit dose within the range 5-5000mg per square metre body area of the animal, i.e. approximately O.l-lOOmg/kg. A unit dose in the range, for example, 1-lOOmg/kg, preferably l-50mg/kg is envisaged and this normally provides a therapeutically-effective dose. A unit dose form such as a tablet or capsule will usually contain, for example l-250mg of active ingredient. According to a further aspect of the present invention there is provided a compound of the formula I or a pharmaceutically acceptable salt thereof as defined hereinbefore for use in a method of treatment of the human or animal body by therapy. We have found that compounds of the present invention inhibit VEGF receptor tyrosine kinase activity and FGF Rl receptor tyrosine kinase activity and are therefore of interest for their antiangiogenic effects and/or their ability to cause a reduction in vascular permeability. A further feature of the present invention is a compound of formula I, or a pharmaceutically acceptable salt thereof, for use as a medicament, conveniently a compound of formula I, or a pharmaceutically acceptable salt thereof, for use as a medicament for producing an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human being. Thus according to a further aspect of the invention there is provided the use of a compound of the formula I, or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human being. According to a further feature of the invention there is provided a method for producing an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal, such as a human being, in need of such treatment which comprises administering to said animal an effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof as defined hereinbefore. As stated above the size of the dose required for the therapeutic or prophylactic treatment of a particular disease state will necessarily be varied depending on the host treated, the route of administration and the severity of the illness being treated. Preferably a daily dose in the range of l-50mg/kg is employed. However the daily dose will necessarily be varied depending upon the host treated, the particular route of administration, and the severity of the illness being treated. Accordingly the optimum dosage may be determined by the practitioner who is treating any particular patient. The antiangiogenic and/or vascular permeability reducing treatment defined hereinbefore may be applied as a sole therapy or may involve, in addition to a compound of the invention, one or more other substances and/or treatments. Such conjoint treatment may be achieved by way of the simultaneous, sequential or separate administration of the individual components of the treatment. In the field of medical oncology it is normal practice to use a combination of different forms of treatment to treat each patient with cancer. In medical oncology the other component(s) of such conjoint treatment in addition to the antiangiogenic and/or vascular permeability reducing treatment defined hereinbefore may be: surgery, radiotherapy or chemotherapy. Such chemotherapy may cover three main categories of therapeutic agent: (i) other antiangiogenic agents that work by different mechanisms from those defined hereinbefore (for example linomide, inhibitors of integrin αvβ3 function, angiostatin, razoxin, thalidomide); (ii) cytostatic agents such as antioestrogens (for example tamoxifen,toremifene, raloxifene, droloxifene, iodoxyfene), progestogens (for example megestrol acetate), aromatase inhibitors (for example anastrozole, letrazole, vorazole, exemestane), antiprogestogens, antiandrogens (for example flutamide, nilutamide, bicalutamide, cyproterone acetate), LHRH agonists and antagonists (for example goserelin acetate, luprolide), inhibitors of testosterone 5α- dihydroreductase (for example finasteride), anti-invasion agents (for example metalloproteinase inhibitors like marimastat and inhibitors of urokinase plasminogen activator receptor function) and inhibitors of growth factor function, (such growth factors include for example EGF, platelet derived growth factor and hepatocyte growth factor such inhibitors include growth factor antibodies, growth factor receptor antibodies, tyrosine kinase inhibitors and serine/threonine kinase inhibitors); and (iii) antiproliferative/antineoplastic drugs and combinations thereof, as used in medical oncology, such as antimetabolites (for example antifolates like methotrexate, fluoropyrimidines like 5-fluorouracil, purine and adenosine analogues, cytosine arabinoside); antitumour antibiotics (for example anthracyclines like doxorubicin, daunomycin, epirubicin and idarubicin, mitomycin-C, dactinomycin, mithramycin); platinum derivatives (for example cisplatin, carboplatin); alkylating agents (for example nitrogen mustard, melphalan, chlorambucil, busulphan, cyclophosphamide, ifosfamide, nitrosoureas, thiotepa); antimitotic agents (for example vinca alkaloids like vincristine and taxoids like taxol, taxotere); topoisomerase inhibitors (for example epipodophyllotoxins like etoposide and teniposide, amsacrine, topotecan). As stated above the compounds defined in the present invention are of interest for their antiangiogenic and/or vascular permeability reducing effects. Such compounds of the invention are expected to be useful in a wide range of disease states including cancer, diabetes, psoriasis, rheumatoid arthritis, Kaposi's sarcoma, haemangioma, acute and chronic nephropathies, atheroma, arterial restenosis, autoimmune diseases, acute inflammation and ocular diseases with retinal vessel proliferation. In particular such compounds of the invention are expected to slow advantageously the growth of primary and recurrent solid tumours of, for example, the colon, breast, prostate, lungs and skin. More particularly such compounds of the invention are expected to inhibit the growth of those primary and recurrent solid tumours which are associated with VEGF and/or FGF, especially those tumours which are significantly dependent on VEGF and/or FGF for their growth and spread, including for example, certain tumours of the colon, breast, prostate, lung, vulva and skin. In addition to their use in therapeutic medicine, the compounds of formula I and their pharmaceutically acceptable salts are also useful as pharmacological tools in the development and standardisation of in vitro and in vivo test systems for the evaluation of the effects of inhibitors of VEGF receptor tyrosine kinase activity and FGF Rl receptor tyrosine kinase activity in laboratory animals such as cats, dogs, rabbits, monkeys, rats and mice, as part of the search for new therapeutic agents. It is to be understood that where the term "ether" is used anywhere in this specification it refers to diethyl ether. The invention will now be illustrated in the following non-limiting Examples in which, unless otherwise stated: - [(i) evaporations were carried out by rotary evaporation in vacuo and work-up procedures were carried out after removal of residual solids such as drying agents by filtration; (ii) operations were carried out at ambient temperature, that is in the range 18-25°C and under an atmosphere of an inert gas such as argon; (iii) column chromatography (by the flash procedure) and medium pressure liquid chromatography (MPLC) were performed on Merck Kieselgel silica (Art. 9385) or Merck Lichroprep RP-18 (Art. 9303) reversed-phase silica obtained from E. Merck, Darmstadt, Germany; (iv) yields are given for illustration only and are not necessarily the maximum attainable; (v) melting points are uncorrected and were determined using a Mettler SP62 automatic melting point apparatus, an oil-bath apparatus or a Koffler hot plate apparatus. (vi) the structures of the end-products of the formula I were confirmed by nuclear (generally proton) magnetic resonance (NMR) and mass spectral techniques; proton magnetic resonance chemical shift values were measured on the delta scale and peak multiplicities are shown as follows: s, singlet; d, doublet; t, triplet; m, multiplet; br, broad; q, quartet, quin, quintet; (vii) intermediates were not generally fully characterised and purity was assessed by thin layer chromatography (TLC), high-performance liquid chromatography (HPLC), infra-red (IR) or NMR analysis; (viii) petroleum ether refers to that fraction boiling between 40-60°C (ix) the following abbreviations have been used:- DMF N,N-dimethylformamide DMSO dimethylsulphoxide TFA trifluoroacetic acid THF tetrahydrofuran.] Example 1 7-Azaoxindole hydrobromide (269mg, 1.25mmol), (Tet.Let. 1987, 28, 4027), was added to a suspension of sodium hydride (lOOmg, 2.5mmol, prewashed with hexane) in a mixture of THF (3ml) and DMF (3ml). After stirring for 40 minutes at ambient temperature, 4-chloro-7-methoxy-6-(3-moφholinopropoxy)quinazoline (169mg, 0.5mmol) was added. After heating for 1 hour at 75°C, the volatiles were removed by evaporation. The residue was partitioned between ethyl acetate and water. The aqueous layer was separated and adjusted to pH8 with 2M hydrochloric acid. After extraction with methylene chloride, the organic layer was dried (MgSO 4 ), filtered and the volatiles removed by evaporation. The residue was dissolved in methylene chloride/methanol and 3M hydrogen chloride in ether (0.5ml) was added. After dilution with ether, the solid was collected by filtration and dried under vacuum to give 4-(7-azaoxindol-3-yl)-7-methoxy-6-(3-morpholinopropoxy)quinazoline (150mg, 59%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 2.3(m, 2H); 3.1-3.2(m, 2H); 3.3(m, 2H); 3.5(d, 2H); 3.8(t, 2H); 4.0(s, 3H); 4.05(m, 2H); 4.25(t, 2H); 7.25(s, 1H); 7.3(dd, 1H); 7.95(d, 1H); 8.72(s, 1H); 8.6-8.8(m, 2H) MS - ESI: 436 [MH] + Elemental analysis: Found C 51.4 H 5.8 N 12.7% C 23 H 25 N 5 O 4 2.3HC1 1.2H 2 O Requires C 51.1 H 5.5 N 12.9% The starting material was prepared as follows: A suspension of 4-(3-chloro-4-fluoroanilino)-7-methoxy-6-(3- moφholinopropoxy)quinazoline (6.0g, 13.4mmol), (WO 96/33980), in 6M hydrochloric acid (120ml) was heated at reflux for 6 hours. The mixture was cooled to 0°C and carefully, with cooling, was neutralised by addition of concentrated aqueous ammonia. The resulting precipitate was collected by filtration, washed with dilute aqueous ammonia and water and dried under vacuum to give 7-methoxy-6-(3-moφholinopropoxy)-3,4-dihydroquinazolin-4- one (4.2g, 98%yield). 1H NMR Spectrum: (DMSOd 6 ) 2.4(m, 6H); 3.59(t, 4H); 3.75(t, 2H); 3.90(s, 3H); 4.12(t, 2H); 7.12(s, 1H); 7.43 (s, 1H); 7.98 (s, 1H); 12.0(br s, 1H) MS - ESI: 320 [MH] + Elemental analysis: Found C 58.6 H 6.5 N 12.7% Cι 6 H 2 ιN 3 O 4 0.5H 2 O Requires C 58.5 H 6.7 N 12.8% A solution of 7-methoxy-6-(3-moφholinopropoxy)-3,4-dihydroquinazolin-4-one (990mg, 3.1mmol) in thionyl chloride (10ml) containing DMF (0.1ml) was heated at 80°C for 1.5 hours. After cooling, toluene was added and the solvent was removed by evaporation. The residue was triturated with ether, and the volatiles were removed by evaporation. The residue was partitioned between ethyl acetate and water and the aqueous layer was adjusted to pH7.5 with 2M sodium hydroxide. The organic layer was washed with brine, dried (MgSO 4 ) and the volatiles removed by evaporation. The residue was purified by flash chromatography eluting with methylene chloride/methanol (1/9 followed by 95/5). The solid was triturated with hexane, collected by filtration and washed with ether to give 4-chloro-7-methoxy-6-(3- moφholinopropoxy)quinazoline (614mg, 58%). 1H NMR Spectrum: (CDC1 3 ) 2.12(m, 2H); 2.50(br s, 4H); 2.59(t, 2H); 3.73(t, 4H); 4.05(s, 3H); 4.27(t, 2H); 7.33(s, 1H); 7.40(s, 1H); 8.86(s, 1H) Example 2 A solution of 7-azaoxindole (268mg, 2mmol) in THF (3ml) was added to a suspension of sodium hydride (80mg, 2mmol, prewashed with THF) in THF (4ml). After stirring for 20 minutes at ambient temperature a solution of 4-chloro-6-methoxy-7-(2- methoxyethoxy)quinazoline (180mg, 0.7mmol) in a mixture of THF (3ml) and DMF (1ml) was added. After stirring for 30 minutes at ambient temperature followed by 1 hour at 65°C, the volatiles were removed by evaporation. The residue was partitioned between water and ether. The aqueous layer was separated and adjusted to pH4 with 2M hydrochloric acid. The precipitate was collected by filtration and dried under vacuum, it was then suspended in methylene chloride/methanol (1/1) and 3M hydrogen chloride in ether was added. The solid was collected by filtration, washed with methanol followed by ether and dried under vacuum to give 4-(7-azaoxindol-3-yI)-6-methoxy-7-(2-methoxyethoxy)quinazoline (388mg, 68%). 1H NMR Spectrum: (DMSOd 6 , NaOD, D 2 O) 3.44(s, 3H); 3.85(t, 2H); 3.90(s, 3H); 4.27(t, 2H); 6.51(dd, IH); 6.98(s, IH); 7.51(d, IH); 8.05-8.15(m, IH); 8.45(s, IH); 9.3(br s, IH) MS - ESI: 367 [MH] + Elemental analysis: Found C 50.6 H 4.7 N 12.3% C, 9 Hι 8 N 4 O 4 0.9H 2 O 1.85HC1 Requires C 50.7 H 4.8 N 12.4% The starting material was prepared as follows: A mixture of ethyl 4-hydroxy-3-methoxybenzoate (9.8g, 50mmol), 2-bromoethyl methyl ether (8.46ml, 90mmol) and potassium carbonate (12.42g, 90mmol) in acetone (60ml) was heated at reflux for 30 hours. The mixture was allowed to cool and the solids removed by filtration. The volatiles were removed from the filtrate by evaporation and the residue triturated with hexane to give ethyl 3-methoxy-4-(2-methoxyethoxy)benzoate (11.3g, 89%) as a white solid. m.p. 57-60°C Η NMR Spectrum: (DMSOd 6 ) 1.31(t, 3H); 3.29(s, 3H); 3.32(s, 3H); 3.68(m, 2H); 4.16(m, 2H); 4.28(q, 2H); 7.06(d, IH); 7.45(d, IH); 7.56(dd, IH) MS - FAB: 255 [MH] + Ethyl 3-methoxy-4-(2-methoxyethoxy)benzoate (9.5g, 37mmol) was added in portions to stirred concentrated nitric acid (75ml) at 0°C. The mixture was allowed to warm to ambient temperature and stirred for a further 90 minutes. The mixture was diluted with water and extracted with methylene chloride, dried (MgSO 4 ) and the solvent removed by evaporation. The residue was triturated with hexane to give ethyl 5-methoxy-4-(2- methoxyethoxy)-2-nitrobenzoate (10.6g, 95%) as an orange solid. m.p. 68-69°C 1H NMR Spectrum: (DMSOd 6 ) 1.27(t, 3H); 3.30(s, 3H); 3.69(m, 2H); 3.92(s, 3H); 4.25(m, 2H); 4.29(q, 2H); 7.30(s, IH); 7.65(s, IH) MS - CI: 300 [MH] + A mixture of ethyl 5-methoxy-4-(2-methoxyethoxy)-2-nitrobenzoate ( 10.24g, 34mmol), cyclohexene (30ml) and 10% palladium-on-charcoal catalyst (2.0g) in methanol (150ml) was heated at reflux for 5 hours. The reaction mixture was allowed to cool and diluted with methylene chloride. The catalyst was removed by filtration and the volatiles removed from the filtrate by evaporation. The residue was recrystallised from ethyl acetate/hexane to give ethyl 2-amino-5-methoxy-4-(2-methoxyethoxy) benzoate (8.0g) as a buff solid. Formamide (80ml) was added to this product and the mixture heated at 170°C for 18 hours. About half the solvent was removed by evaporation under high vacuum and the residue was left to stand overnight. The solid product was collected by filtration, washed with ether and dried to give 6-methoxy-7-(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one (5.3g, 62% over two steps) as a grey solid. 1H NMR Spectrum: (DMSOd 6 ) 3.35(s, 3H); 3.74(m, 2H); 3.89(s, 3H); 4.26(m, 2H); 7.15(s, IH); 7.47(s, IH); 7.98(s, IH); 12.03(br s, 1 H) MS - CI: 251 [MH] + DMF (0.5ml) was added to a mixture of 6-methoxy-7-(2-methoxyethoxy)-3,4- dihydroquinazolin-4-one (5.1g, 20mmol) in thionyl chloride (50ml). The mixture was stirred and heated at reflux for 3 hours, allowed to cool and the excess thionyl chloride removed by evaporation. The residue was suspended in methylene chloride and washed with aqueous sodium hydrogen carbonate solution. The aqueous phase was extracted with methylene chloride and the combined extracts dried (MgSO 4 ). The crude product was recrystallised from methylene chloride/hexane to give 4-chloro-6-methoxy-7-(2-methoxyethoxy)quinazoline (2.8g, 51%) as a fine white solid. 1H NMR Spectrum: (DMSOd 6 ) 3.37(s, 3H); 3.77(m, 2H); 4.01(s, 3H); 4.37(m, 2H); 7.40(s, IH); 7.49(s, IH); 8.88(s, IH) MS - CI: 269 [MH] + A suspension of 7-azaoxindole hydrobromide (800mg, 3.7mmol), (Tet.Let. 1987, 28, 4027), in methylene chloride (10ml) was adjusted to pH9 with saturated aqueous sodium hydrogen carbonate solution. The organic layer was separated and the aqueous layer was extracted with methylene chloride. The organic layers were combined, washed with brine, dried (MgSO 4 ) and the volatiles removed by evaporation. The residue was purified by column chromatography eluting with methylene chloride/methanol (95/5) to give 7-azaoxindole free base (238mg, 48%). Example 3 A solution of 7-azaoxindole (284mg, 2.1mmol), (prepared as described for the starting material in Example 2), in THF (10ml) was added to a suspension of sodium hydride (112mg, 2.8mmol, prewashed with petroleum ether) in THF (6ml). After stirring for 20 minutes at ambient temperature, a solution of 4-chloro-6-methoxy-7-(3- moφholinopropoxy)quinazoline (238mg, 0.7mmol) in a mixture of THF (3ml) and DMF (lml) was added. After stirring for 1 hour at 65°C, the volatiles were removed by evaporation. The residue was partitioned between water and ether. The aqueous layer was separated and adjusted to pH7 with 2M hydrochloric acid. After evaporation of water, the precipitate was triturated with ether, collected by filtration, washed with ether, and dried under vacuum. The residue was purified by column chromatography eluting with methylene chloride/methanol (95/5 followed by 90/10). After evaporation of the solvent, the residue was suspended in methylene chloride/methanol (1/1) and 3M hydrogen chloride in ether was added. After removal of the solvent by evaporation, the solid was collected by filtration, washed with ether and dried under vacuum to give 4-(7-azaoxindol-3-yl)-6-methoxy-7-(3- morpholinopropoxy)quinazoline (150mg, 51%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 2.25-2.35(m, 2H); 3.1-3.2(m, 2H); 3.3-3.4(m, 2H); 3.5-3.6(d, 2H); 3.8(t, 2H); 3.95(s, 3H); 4.05(d, 2H); 4.35(t, 2H); 7.3(m, 2H); 7.95(d, IH); 8.5-8.7(m, 2H); 8.85(s, IH) MS - ESI: 436 [MH] + Elemental analysis: Found C 52.9 H 5.8 N 13.2% C 23 H 25 NsO 4 1.2HC1 0.9H 2 O Requires C 53.0 H 5.6 N 13.4% The starting material was prepared as follows: A mixture of 4-hydroxy-3-methoxybenzoic acid (4.5g, 26.8mmol), 3- moφholinopropyl chloride (9.5g, 58.0mmol), (prepared according to J. Am. Chem. Soc. 1945, 67, 736), potassium carbonate (8.0g, 58mmol), potassium iodide (l.Og, 0.22mmol) and DMF (80ml) was stirred and heated at 100°C for 3 hours. The solid was removed by filtration and the volatiles were removed from the filtrate by evaporation. The residue was dissolved in ethanol (50ml), 2M sodium hydroxide (50ml) was added and the mixture was heated at 90°C for 2 hours. After partial evaporation, the mixture was acidified with concentrated hydrochloric acid, washed with ether and then subjected to purification on a Diaion (trade mark of Mitsubishi) HP20SS resin column, eluting with water and then with a gradient of methanol (0 to 25%) in hydrochloric acid (pH2). Partial evaporation of the solvents and lyophilisation gave 3-methoxy-4-(3-moφholinopropoxy)benzoic acid (8.65g, 97%). 1H NMR Spectrum: (DMSOde, TFA) 2.17-2.24(m, 2H); 3.10-3.16(m, 2H); 3.30(t, 2H); 3.52(d, 2H); 3.7 l(t, 2H); 3.82(s, 3H); 4.01(br d, 2H); 4.14(t, 2H); 7.08(d, IH); 7.48(d, IH); 7.59(dd, IH) MS - ESI: 296 [MH] + Fuming nitric acid (1.5ml, 36.2mmol) was added slowly at 0°C to a solution of 3- methoxy-4-(3-moφholinopropoxy)benzoic acid (7.78g, 23.5mmol) in TFA (25ml). The cooling bath was removed and the reaction mixture stirred at ambient temperature for 1 hour. The TFA was evaporated and ice was added to the residue. The precipitate was collected by filtration and washed with a minimum of water followed by toluene and ether. The solid was dried under vacuum over phosphorus pentoxide to give 5-methoxy-4-(3-moφholinopropoxy)- 2-nitrobenzoic acid trifluoroacetate (7.54g, 71%yield) which was used without further purification. Η NMR Spectrum: (DMSOd 6 , TFA) 2.16-2.23(m, 2H); 3.10-3.17(m, 2H); 3.30(t, 2H); 3.52(d, 2H); 3.66(t, 2H); 3.93(s, 3H); 4.02(br d, 2H); 4.23(t, 2H); 7.34(s, IH); 7.61(s, IH) MS - El: 340 [M] + Thionyl chloride (15ml) and DMF (0.05ml) were added to 5-methoxy-4-(3- moφholinopropoxy)-2-nitrobenzoic acid trifluoroacetate (7.54g, 16.6mmol). The mixture was heated at 50°C for 1 hour, the excess thionyl chloride was removed by evaporation and by azeotroping with toluene (x2). The resulting solid was suspended in THF (200ml) and ammonia was bubbled through the mixture for 30 minutes. The precipitate was removed by filtration, washed with THF and discarded.. After concentration of the filtrate by evaporation, the product crystallised and was collected by filtration to give 5-methoxy-4-(3- moφholinopropoxy)-2-nitrobenzamide (5.25g, 93%yield) as light yellow crystals which were used without further purification. 1H NMR Spectrum: (DMSOd 6 , TFA) 2.17-2.24(m, 2H); 3.11-3.18(m, 2H); 3.3 l(t, 2H); 3.53(d, 2H); 3.67(t, 2H); 3.93(s, 3H); 4.03(br d, 2H); 4.21(t, 2H); 7.17(s, IH); 7.62(s, IH) MS - El: 339 [M] + Concentrated hydrochloric acid (30ml) was added to a suspension of 5-methoxy-4- (3-moφholinopropoxy)-2-nitrobenzamide (5.67g, 16.7mmol) in methanol (150ml) and the mixture was heated to 60°C. When the 5-methoxy-4-(3-moφholinopropoxy)-2- nitrobenzamide had dissolved, iron powder (5.6g, lOOmmol) was added in portions to the reaction mixture which was then heated at 60°C for 90 minutes. After cooling, the insolubles were removed by filtration through diatomaceous earth, the volatiles were removed from the filtrate by evaporation and the residue was purified on a Diaion (trade mark of Mitsubishi) HP20SS resin column, eluting with water and then with hydrochloric acid (pH2). Concentration of the fractions by evaporation gave a precipitate which was collected by filtration and dried under vacuum over phosphorus pentoxide to give 2-amino-5-methoxy-4- (3-moφholinopropoxy)benzamide as a hydrochloride salt (4.67g, 75%) as beige crystals. 1H NMR Spectrum: (DMSOd 6 , TFA) 2.22-2.28(m, 2H); 3.12(br t, 2H); 3.29(t, 2H); 3.5 l(d, 2H); 3.75(t, 2H); 3.87(s, 3H); 4.00(br d, 2H); 4.12(t, 2H); 7.06(s, IH); 7.53(s, IH) MS - El: 309 [M] + A mixture of 2-amino-5-methoxy-4-(3-moφholinopropoxy)benzamide (4.57g, 12.25mmol) and Gold's reagent (2.6g, 15.89mmol) in dioxane (35ml) was heated at reflux for 5 hours. Acetic acid (0.55ml) and sodium acetate (l.Og) were added to the reaction mixture which was heated at reflux for a further 3 hours. The mixture was cooled to ambient temperature and the volatiles removed by evaporation. The residue was adjusted to pH7 with 2M sodium hydroxide and then purified on a Diaion (trade mark of Mitsubishi) HP20SS resin column, eluting with methanol (gradient of 0 to 60%) in water. Concentration of the fractions by evaporation gave a precipitate which was collected by filtration and dried under vacuum over phosphorus pentoxide to give 4-hydroxy-6-methoxy-7-(3- moφholinopropoxy)quinazoline (3.04g, 78%) as a white solid. 1H NMR Spectrum: (CDC1 3 ) 2.10(q, 2H); 2.48(m, 4H); 2.56(t, 2H); 3.72(t, 4H); 4.00(s, 3H); 4.24(t, 2H); 7.18(s, IH); 7.60(s, IH); 8.00(s, IH); 10.86(br s, IH) MS - EI: 319 [M] + A mixture of 4-hydroxy-6-methoxy-7-(3-moφholinopropoxy)quinazoline (638mg, 2mmol) and thionyl chloride (8ml) was heated at reflux for 30 minutes. Excess thionyl chloride was removed by evaporation and by azeotroping with toluene (x2). The residue was suspended in methylene chloride and a 10% aqueous solution of sodium hydrogen carbonate (50ml) was added to the mixture. The organic layer was separated, dried (MgSO ) and the solvent removed by evaporation. The residue was triturated with ether, the solid was collected by filtration, washed with ether and dried under vacuum to give 4-chloro-6-methoxy-7-(3- moφholinopropoxy)quinazoline (590mg, 87%). 1H NMR Spectrum: (CDC1 3 ) 2.10-2.16(m, 2H); 2.48(br s, 4H); 2.57(t, 2H); 3.73(t, 4H); 4.05(s, 3H); 4.29(t, 2H); 7.36(s, IH); 7.39(s, IH); 8.86(s, IH) MS - ESI: 337 [MH] + Example 4 A solution of 7-azaoxindole (170mg, 1.27mmol), (prepared as described for the starting material in Example 2), in THF (3ml) was added to a suspension of sodium hydride (51mg, 1.27mmol, prewashed with hexane) in THF (3ml). After stirring for 30 minutes at ambient temperature, a solution of 4-chloro-6-methoxy-7-(2-(pyrrolidin- 1 - yl)ethoxyquinazoline (130mg, 0.42mmol) in DMF (2ml) was added. After heating at 60°C for 30 minutes, the volatiles were removed by evaporation. The residue was partitioned between methylene chloride and water. The aqueous layer was adjusted to pH2 with 2M hydrochloric acid. The aqueous layer was evaporated. The residue was suspended in water and the aqueous layer was adjusted to pH9 with 2M sodium hydroxide and extracted with methylene chloride. The organic layer was washed with brine, dried (MgSO ) and evaporated. The residue was purified by chromatography on neutral alumina eluting with a gradient of methylene chloride/methanol (9/10 to 1/9). After evaporation of the solvent, the residue was dissolved in methylene chloride/methanol (1/1) and 2M hydrogen chloride in methanol was added. The volatiles were removed by evaporation and the residue was triturated with ether, collected by filtration and dried under vacuum to give 4-(7-azaoxindol-3-yl)-6-methoxy-7-(2- (pyrrolidin-l-yl)ethoxy)quinazoline (33mg, 18%). Η NMR Spectrum: (DMSOd 6 , NaOD, D 2 O) 1.7(br s, 4H); 2.6(s, 4H); 2.9(t, 2H); 3.85(s, 3H); 4.2(t, 2H); 6.4(dd, IH); 6.9(s, IH); 7.4(d, IH); 7.95(d, IH); 8.35(s, IH); 9.1(s, IH) MS - ESI: 406 [MH] + Elemental analysis: Found C 48.2 H 5.7 N 12.7% C 22 H 23 N 5 O 3 2HC1 3.7H 2 O Requires C 48.5 H 6.0 N 12.8% The starting material was prepared as follows: A mixture of 2-amino-4-benzyloxy-5-methoxybenzamide (lOg, 0.04mol), (J. Med. Chem. 1977, vol 20, 146-149), and Gold's reagent (7.4g, 0.05mol) in dioxane (100ml) was stirred and heated at reflux for 24 hours. Sodium acetate (3.02g, 0.037mol) and acetic acid (1.65ml, 0.029mol) were added to the reaction mixture and it was heated at reflux for a further 3 hours. The volatiles were removed by evaporation, water was added to the residue, the solid was collected by filtration, washed with water and dried. Recrystallisation from acetic acid gave 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one (8.7g, 84%). A mixture of 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one (2.82g, O.Olmol), thionyl chloride (40ml) and DMF (0.28ml) was stirred and heated at reflux for 1 hour. The mixture was evaporated and azeotroped with toluene to give 7-benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride (3.35g). 7-Benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride (3.35g) was dissolved in methylene chloride (250ml) and washed with sodium hydrogen carbonate until the aqueous layer was adjusted to pH8. The organic layer was washed with brine, dried (MgSO 4 ) and evaporated to give 7-benzyloxy-4-chloro-6-methoxyquinazoline (2.9g, 96%). Sodium hydride (400mg of an 80% suspension in paraffin oil, 13.3mmol) was added to a solution of phenol (1.26g, 13.3mmol) in dry l-methyl-2-pyrrolidinone (20ml) and the mixture stirred for 10 minutes. 7-Benzyloxy-4-chloro-6-methoxyquinazoline (1.6g, 5.3mmol), was then added and the reaction mixture heated at 110°C for 2 hours. The mixture was allowed to cool, water was added and the mixture extracted with ethyl acetate (3x 100ml). The combined extracts were then washed with 2M sodium hydroxide solution, water and brine. Removal of the solvent under reduced pressure gave 7-benzyloxy-6-methoxy-4-phenoxyquinazoline (1.6g, 84%) as a yellowish solid. Η NMR Spectrum: (DMSOd 6 ) 3.98(s, 3H); 5.37(s, 2H); 7.25-7.6(m, 11H); 7.60(s, IH); 8.54(s, IH) MS - ESI: 300 [MH] + 7-Benzyloxy-6-methoxy-4-phenoxyquinazoline (160mg, 0.44mmol) in TFA (3ml) was heated at reflux for 30 minutes. The solvent was removed by evaporation and the residue treated with aqueous sodium hydrogen carbonate solution. The precipitated product was collected by filtration, washed with water and dried to give 7-hydroxy-6-methoxy-4- phenoxyquinazoline (105mg, 88%). 1H NMR Spectrum: (DMSOd 6 ) 4.00(s, 3H); 7.20(s, IH); 7.25-7.35(m, 3H); 7.4-7.55(m, 2H); 7.58(s, IH); 10.73(s, 1 H) MS - ESI: 269 [MH] + l-(2-Chloroethyl)pyrrolidine hydrochloride (1.27g, 7.5mmol) was added to 7- hydroxy-6-methoxy-4-phenoxyquinazoline (l.Og, 3.7mmol), and potassium carbonate (3.9g, 28.3mmol) in DMF (30ml). The mixture was heated at 110°C for 4 hours and allowed to cool. The mixture was filtered, and the volatiles were removed from the filtrate by evaporation. The residue was purified by column chromatography eluting with methylene chloride/methanol/ammonia, (100/8/1) to give an oil which was triturated with ethyl acetate to give 6-methoxy-4-phenoxy-7-(2-(pyrrolidin-l-yl)ethoxy)quinazoline (200mg, 15%) as a white solid. 1H NMR Spectrum: (DMSOd 6 ) 1.65(m, 4H); 2.55(m, 4H); 2.85(t, 2H); 3.95(s, 3H); 4.25(t, 2H); 7.30(m, 3H); 7.38(s, IH); 7.50(m, 2H); 7.55(s, IH); 8.5(s, IH) MS - ESI: 366 [MH] + A mixture of 6-methoxy-4-phenoxy-7-(2-(pyrrolidin-l-yl)ethoxy)quinazoline (565mg, 1.55mmol) and 2M hydrochloric acid (5ml) was heated at 90°C for 90 minutes and allowed to cool. The solution was neutralised with aqueous sodium hydrogen carbonate, and the water removed by evaporation. The residue was purified by column chromatography eluting with methylene chloride/methanol/ammonia (100/8/1) to give 6-methoxy-7-(2- (pyrrolidin-l-yl)ethoxy)-3,4-dihydroquinazolin-4-one (440mg, 98%yield). This material was used without further characterisation. A solution of 6-methoxy-7-(2-(pyrrolidin- 1 -yl)ethoxy-3 ,4-dihydroquinazolin-4-one (909mg, 3.14mmol) in thionyl chloride (12ml) containing DMF (0.5ml) was refluxed for 1 hour. After cooling toluene was added and the volatiles were removed by evaporation. The residue was partitioned between methylene chloride and water and the aqueous layer was adjusted to pH8 with sodium hydrogen carbonate. The organic layer was separated, washed with brine, dried (MgSO 4 ), filtered and evaporated. The residue was purified by flash chromatography eluting with methylene chloride/methanol (95/5 followed by 85/15). The residue was triturated with ether, collected by filtration and dried under vacuum to give 4- chloro-6-methoxy-7-(2-(pyrrolidin-l-yl)ethoxyquinazoline (638mg, 66%). Η NMR Spectrum: (DMSOdo) 1.7(br s, 4H); 2.56(br s, 4H); 2.9(t, 2H); 4.0(s, 3H); 4.32(t, 2H); 7.4(s, IH); 7.48(s, IH); 8.9(s, IH) MS - ESI: 308 [MH] + Example 5 A solution of 7-azaoxindole (165mg, 1.23mmol), (prepared as described for the starting material in Example 2), in DMF (3ml) was added dropwise to a suspension of sodium hydride (50mg, 1.23mmol, prewashed with hexane) in DMF (3ml). After stirring for 30 minutes at ambient temperature, 4-chloro-7-(2-(imidazol-l-yl)ethoxy)-6-methoxy quinazoline (125mg, 0.41mmol) in DMF (3ml) was added. The mixture was heated at 65°C for 30 minutes. After cooling the mixture was partitioned between saturated aqueous ammonium chloride and methylene chloride. The precipitate was collected by filtration, dried and purified by flash chromatography eluting with methylene chloride/methanol (8/2). After evaporation of the solvent, the solid was dissolved in methylene chloride/methanol and 2.2 M hydrogen chloride in ether was added. After stirring for 10 minutes at ambient temperature, the volatiles were removed by evaporation. The residue was triturated with ether, collected by filtration and dried under vacuum to give 4-(7-azaoxindol-3-yI)-7-(2-(imidazol-l-yl)ethoxy)- 6-methoxyquinazoline (HOmg, 53%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 3.89(s, 3H); 4.65(t, 2H); 4.8(t, 2H); 7.29(d, IH); 7.31(s, IH); 7.73(s, IH); 7.84(s, IH); 7.92(d, IH); 8.5-8.6(m, IH); 8.65-8.70(m, IH); 8.71(s, IH); 9.22(s, IH) MS - ESI: 403 [MH] + Elemental analysis: Found C 49.3 H 4.4 N 16.3% C 2 ιHι 8 N 6 O 3 1.8H 2 O 2.1HCl Requires C 49.3 H 4.7 N 16.4% The starting material was prepared as follows: A mixture of 2-amino-4-benzyloxy-5-methoxybenzamide (lOg, 0.04mol), (J. Med. Chem. 1977, vol 20, 146-149), and Gold's reagent (7.4g, 0.05mol) in dioxane (100ml) was stirred and heated at reflux for 24 hours. Sodium acetate (3.02g, 0.037mol) and acetic acid (1.65ml, 0.029mol) were added to the reaction mixture and it was heated at reflux for a further 3 hours. The volatiles were removed by evaporation, water was added to the residue, the solid was collected by filtration, washed with water and dried. Recrystallisation from acetic acid gave 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one (8.7g, 84%). Sodium hydride (1.44g of a 60% suspension in mineral oil, 36mmol) was added in portions over 20 minutes to a solution of 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4- one (8.46g, 30mmol) in DMF (70ml) and the mixture was stirred for 1.5 hours. Chloromethyl pivalate (5.65g, 37.5mmol) was added dropwise and the mixture stirred for 2 hours at ambient temperature. The mixture was diluted with ethyl acetate (100ml) and poured onto ice/water (400ml) and 2M hydrochloric acid (4ml). The organic layer was separated and the aqueous layer extracted with ethyl acetate, the combined extracts were washed with brine, dried (MgSO 4 ) and the volatiles removed by evaporation. The residue was triturated with a mixture of ether and petroleum ether, the solid was collected by filtration and dried under vacuum to give 7-benzyloxy-6-methoxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one ( lOg, 84%). 1H NMR Spectrum: (DMSOd 6 ) 1.1 l(s, 9H); 3.89(s, 3H); 5.3(s, 2H); 5.9(s, 2H); 7.27(s, IH); 7.35(m, IH); 7.47(t, 2H); 7.49(d, 2H); 7.51(s, IH); 8.34(s, IH) A mixture of 7-benzyloxy-6-methoxy-3-((pivaloyloxy)methyl)-3,4- dihydroquinazolin-4-one (7g, 17.7mmol) and 10% palladium-on-charcoal catalyst (700mg) in ethyl acetate (250ml), DMF (50ml), methanol (50ml) and acetic acid (0.7ml) was stirred under hydrogen at atmospheric pressure for 40 minutes. The catalyst was removed by filtration and the volatiles removed from the filtrate by evaporation. The residue was triturated with ether, collected by filtration and dried under vacuum to give 7-hydroxy-6-methoxy-3- ((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (4.36g, 80%). 1H NMR Spectrum: (DMSOd 6 ) l.l(s, 9H); 3.89(s, 3H); 5.89(s, 2H); 7.0(s, IH); 7.48(s, IH); 8.5(s, IH) Diethyl azodicarboxylate (435mg, 2.5mmol) was added dropwise to a suspension of 7-hydroxy-6-methoxy-3-((pivaloyloxy )methyl)-3 ,4-dihydroquinazolin-4-one (612mg, 2mmol) , 2-(imidazol-l-yl)ethanol (280mg, 2.5mmol), (J. Med. Chem. 1993, 25, 4052-4060), and triphenylphosphine (655mg, 2.5mmol) in methylene chloride (10ml) at 5°C. The mixture was stirred for 10 minutes at 5°C and then for 1 hour at ambient temperature. The mixture was poured directly on to a silica column and eluted with methylene chloride/methanol (95/5) to give 7-(2-(imidazol- 1 -yl)ethoxy)-6-methoxy-3-((pivaloyloxy)methyl)-3 ,4-dihydroquinazolin- 4-one (640mg, 80%). 1H NMR Spectrum: (CDC1 3 ) 1.19(s, 9H); 3.98(s, 3H); 4.34(m, 2H); 4.45(m, 2H); 5.94(s, 2H); 7.02(s, IH); 7.07(s, IH); 7.1 l(s, IH); 7.64(s, IH); 7.67(s, IH); 8.17(s, IH) MS - ESI: 423 [MNa] + Elemental Analysis: Found C 58.3 H 6.4 N 13.9% C 2 oH 2 N 4 O 5 0.7H 2 O Requires C 58.2 H 6.2 N 13.6% A solution of 7-(2-(imidazol-l-yl)ethoxy)-6-methoxy-3-((pivaloyloxy)methyl)-3,4- dihydroquinazolin-4-one (640mg, l.όmmol) in saturated methanolic ammonia (10ml) was stirred for 15 hours at ambient temperature. The volatiles were removed by evaporation, the solid was triturated with ether, collected by filtration and dried under vacuum to give 7-(2- (imidazol- 1 -yl)ethoxy)-6-methoxy-3,4-dihydroquinazolin-4-one (412mg, 90%). 1H NMR Spectrum: (DMSOd 6 ) 3.89(s, 3H); 4.4-4.5(m, 4H); 6.9(s, IH); 7.16(s, IH); 7.28(s, IH); 7.47(s, IH); 7.7(s, IH); 7.99(s, IH) MS - ESI: 287 [MH] + Elemental Analysis: Found C 57.8 H 5.2 N 19.3% C, 4 Hι 4 N 4 O 3 0.3H 2 O Requires C 57.7 H 5.1 N 19.2% A mixture of 7-(2-(imidazol- 1 -yl)ethoxy)-6-methoxy-3 ,4-dihydroquinazolin-4-one (412mg, 1.44mmol), thionyl chloride (5 ml) and DMF (0.2ml) was heated at reflux for 1 hour. The mixture was diluted with toluene and the volatiles were removed by evaporation. The residue was suspended in methylene chloride, cooled to 0°C and aqueous sodium hydrogen carbonate solution was added. The resulting precipitate was collected by filtration and dried under vacuum to give 4-chloro-7-(2-(imidazol-l-yl)ethoxy)-6-methoxy quinazoline (258mg, 59%). 1H NMR Spectrum: (DMSOd 6 ) 4.01(s, 3H); 4.47(m, 2H); 4.53(m, 2H); 6.89(s, IH); 7.27(s, IH); 7.41(s, IH); 7.49(s, IH); 7.70(s, IH); 8.88(s, IH) MS - ESI: 327 [MNa] + Example 6 5,7-Diaza-6-methyloxindole (1.3g, 8.7mmol) was added dropwise to a suspension of sodium hydride (500mg, 8.3 mmol, prewashed with hexane) in DMF (100ml). After stirring for 20 minutes at ambient temperature, 4-chloro -7-(3-moφholinopropoxy)quinazoline (1.6g, 5.2mmol) in DMF (10ml) was added and the mixture was heated at 70°C for 1 hour. After cooling, the mixture was diluted with water and adjusted to pHl with 2M hydrochloric acid. The mixture was extracted with ether. The aqueous layer was basified with aqueous sodium hydrogen carbonate and the precipitate was collected by filtration, washed with water, ether and dried under vacuum. The solid was purified by flash chromatography eluting with methylene chloride/methanol (90/10 followed by 80/20) to give a solid. The solid was dissolved in methylene chloride/methanol (1/1) and 5M hydrogen chloride in methanol (0.5ml) was added. The solution was concentrated to a total volume of 2ml and ether (15ml) was added. The solid was filtered, washed with ether and dried under vacuum to give 4-(5,7- diaza-6-methyloxindol-3-yl)-7-(3-morpholinopropoxy)quinazoline (1 29g, 59%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOH) 2.2(m, 2H); 2.65(s, 3H); 3.1(m, 2H); 3.3(t, 2H); 3.5(d, 2H); 3.6(t, 2H); 4.0(d, 2H); 4.2(t, 2H); 7.05(d, IH); 7.2(dd, IH); 8.7(s, IH); 8.95(s, IH); 9.6(m, IH); 9.9(m, IH); 12.3(s, IH) MS - ESI: 421 [MH] + Elemental analysis: Found C 51.1 H 5.3 N 16.1% C 22 H 24 N 6 O 3 2HC1 1.2H 2 O Requires C 51.3 H 5.6 N 16.3% The starting material was prepared as follows: A solution of 2-amino-4-fluorobenzoic acid (3g, 19.3mmol) in formamide (30ml) was heated at 150°C for 6 hours. The reaction mixture was poured onto ice/water 1/1 (250ml). The precipitated solid was collected by filtration, washed with water and dried to give 7-fluoro-3,4-dihydroquinazolin-4-one (2.6g, 82%). Sodium metal (4.4g, 191mmol) was added to benzyl alcohol (100ml) at ambient temperature and the mixture stirred for 30 minutes then heated at 80°C for 1 hour. The mixture was then cooled to 40°C and 7-fluoro-3,4-dihydroquinazolin-4-one (7.8g, 47mmol) was added. The reaction mixture was stirred at 130°C for 4 hours and allowed to cool to ambient temperature and stirred for 18 hours. The solution was quenched with water (800ml) and acidified to pH3 with concentrated hydrochloric acid. The resulting precipitate was collected by filtration, washed with water and ether and dried for 4 hours at 60°C under high vacuum to give 7-benzyloxy-3,4-dihydroquinazolin-4-one (7.02g, 63%). 7-Benzyloxy-3,4-dihydroquinazolin-4-one (7.0g, 27mmol) was suspended in dry DMF (50ml) and sodium hydride was added (1.22g of a 60% suspension in mineral oil, 30mmol). The reaction mixture was allowed to return to ambient temperarture, chloromethyl pivalate (4.75g, 31.5mmol) was added over 10 minutes and the mixture was stirred for 1 hour. The reaction mixture was quenched into water (250ml), the aqueous phase adjusted to pH5 with 2M hydrochloric acid and extracted with ether (3x300ml). The combined ether phases were washed with brine, dried (MgSO ) and the volatiles were removed by evaporation. The solid residue was triturated with isohexane, collected by filtration and dried under vacuum to give 7-benzyloxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (9.1g, 90%). 7-Benzyloxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (8.0g, 22mmol) was dissolved in TFA (40ml) and the mixture was heated at reflux for 3 hours then allowed to cool to ambient temperature and stirred for 18 hours. The TFA was removed by evaporation and the residue resuspended in a mixture of ether and aqueous sodium hydrogen carbonate solution. The solid was collected by filtration, washed with water and ether and dried at 40°C for 3 hours under high vacuum to give 7-hydroxy-3-((pivaloyloxy)methyl)-3,4- dihydroquinazolin-4-one (5.42g, 90%). Moφholine (94g, l.Oδmol) was added dropwise to a solution of 3-bromo-l-propanol (75g, 0.54mol) in toluene (750ml) and the reaction then heated at 80°C for 4 hours. The mixture was allowed to cool to ambient temperature and the precipitated solid was removed by filtration. The volatiles were removed from the filtrate and the resulting yellow oil was purified by distillation at 0.4-0.7 mmHg to give 4-(3-hydroxypropyl)moφholine (40g, 50%) as a colourless oil. b.p. 68-70°C (~0.5mmHg) 1H NMR Spectrum: (DMSOd 6 ) 1.65-1.78(m, 2H); 2.50(t, 4H); 2.60(t, 2H); 3.68(t, 4H); 3.78(t, 2H); 4.90(br d, IH) 7-Hydroxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (750mg, 2.7mmol) was suspended in methylene chloride (40ml) at 5°C and 4-(3-hydroxypropyl)moφholine (490mg, 3.4mmol) and triphenylphosphine (890mg, 3.4mmol) were added. The mixture was stirred for 5 minutes and diethyl azodicarboxylate (590mg, 3.4mmol) was added over 5 minutes at 5°C. The reaction mixture was stirred at 5°C for 30 minutes then at ambient temperature for 1 hour. The solution was then purified directly by column flash chromatography eluting with methylene chloride, and then ethyl acetate, acetonitrile/ethyl acetate (20/80), and acetonitrile/ethyl acetate/ammonia (50/50/0.5). The purified product was triturated with ether/isohexane and collected by filtration to give 7-(3-moφholinopropoxy)-3- ((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (745mg, 68%). 7-(3-Moφholinopropoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (680mg, l.όmmol) was stirred in methanolic ammonia (20ml) at 40°C for 6 hours then for 18 hours at ambient temperature. The solvent was removed by evaporation, the residue was triturated with ether/isohexane and collected by filtration to give 7-(3-moφholinopropoxy)- 3,4-dihydroquinazolin-4-one (450mg, 92%) as a white solid. 1H NMR Spectrum: (DMSOd 6 ) 1.9(quin, 2H); 2.35(t, 4H); 2.4(t, 2H); 3.55(t, 4H); 4.15(t, 2H); 7.05(m, 2H); 7.97(d, IH); 8.02(s, IH) MS: 290 [MH] + A mixture of 7-(3-moφholinopropoxy)-3,4-dihydroquinazolin-4-one (500mg, 1.7mmol), thionyl chloride (10ml) and DMF (0.1ml) was heated at reflux for 2 hours. The volatiles were removed by evaporation and the residue azeotroped with toluene. The crude product was partitioned between methylene chloride (50ml) and saturated aqueous sodium hydrogen carbonate solution (50ml) and the mixture was stirred for 10 minutes. The organic phase was separated and the aqueous phase extracted with methylene chloride. The combined extracts were dried (MgSO 4 ) and the solvent removed by evaporation to give 4-chloro-7-(3- moφholinopropoxy)quinazoline (425mg, 80%). Sodium hydride (lOg of a 60% suspension in oil, 0.25mol) was suspended in toluene (100ml) and diethyl succinate (40g, 0.23mol) was added followed by ethyl formate (21g, 0.285mol). No reaction seemed to take place during the first 30 minutes then the temperature slowly rose to 35°C at which point a strong exotherm was recorded with the temperature rising to 90°C over a few minutes. Once the reaction mixture had cooled to ambient temperature, acetamidine hydrochloride (21g, 0.22mol) in 2-propanol (250ml) was added and the solution heated at reflux for 4 hours. The reaction mixture was directly adsorbed onto lOOg of silica and the solvents removed by rotary evaporation under vacuum. The free flowing powder was poured on the top of a flash chromatography column pre-equilibrated with 5% methanol in ethyl acetate. The polarity of the solvent was gradually increased to 15% methanol in ethyl acetate to give ethyl (2-methyl-4-hydroxypyrimidin-5-yl) acetate (21.3g, 51%). Ethyl (2-methyl-4-hydroxypyrimidin-5-yl) acetate (19.2g, 99mmol) and phosphorus oxychloride (75ml) were heated at 80°C for 2 hours to give an orange solution. The phosphorus oxychloride was removed by rotary evaporation under vacuum and the residual oil was partitioned between methylene chloride (100ml), sodium hydrogen carbonate (250ml of a saturated solution) and ice. More sodium hydrogen carbonate was added until the pH remained at about 8 after a few minutes of stirring. The methylene chloride was separated and the aqueous phase re-extracted again with methylene chloride. The organic phases were combined, washed once with a saturated solution of sodium hydrogen carbonate and brine (1/1) and dried by filtration through a phase separator filter paper (Whatman). Removal of the volatiles by evaporation gave ethyl (2-methyl-4-chloropyrimidin-5-yl) acetate (20.3g, 96%) as an orange oil. Ethyl (2-methyl-4-chloropyrimidin-5-yl) acetate (19.9g, 93mmol) was dissolved in DMF (150ml), sodium azide (6.5g, lOOmmol) was added and this solution was stirred at 60- 70°C for 3 hours. The DMF was removed by evaporation and the residual oil was suspended in methylene chloride, washed once with water (250ml), brine (250ml) and dried by filtration through a phase separator filter paper (Whatman). Removal of the volatiles by evaporation gave ethyl (4-azido-2-methylpyrimidin-5-yl) acetate (19.6g, 95%) as a yellow/orange oil which crystallised overnight. Ethyl (4-azido-2-methylpyrimidin-5-yl) acetate (19.5g, 88mmol) was dissolved in a mixture of ethanol (100ml) and methanol (100ml) and 10% palladium-on-charcoal catalyst (1.5g of a 50% suspension in water) was added. The mixture was then stirred under hydrogen at atmospheric pressure at ambient temperature for 6 hours. Methylene chloride was then added to dissolve the product and the catalyst was removed by filtration. The solvents were evaporated using a rotary evaporator and the residue was triturated with ether and collected by filtration to give ethyl (4-amino-2-methylpyrimidin-5-yl) acetate as an orange solid (16.3g, 95%). Ethyl (4-amino-2-methylpyrimidin-5-yl) acetate (7.2g, 37mmol) was suspended in Dowtherm A (14ml) and heated at 230°C for 3 hours. The reaction mixture was allowed to cool to about 120°C, diluted with toluene (100ml) and stirred until the mixture returned to ambient temperature. The brown solid obtained was collected by filtration, redissolved into methylene chloride and methanol, silica (15g) was added and the volatiles were removed by evaporation. The free flowing powder was placed on the top of a flash chromatography column pre-equilibrated in methylene chloride/methanol/ammonia (100/0 5/0.5) and the product was eluted using methylene chloride/methanol/ammonia (100/10/1). Removal of the volatiles by evaporation gave 5,7-diaza-6-methyloxindole (3.8g, 70%). Example 7 Sodium hydride (83mg, 2. lmmol) was added to 4-aza-6-trifluoromethyloxindole (360mg, 1.8mmol) in DMF (7ml) and the solution was carefully degassed using alternatively vacuum and argon. After being stirred for 15 minutes at ambient temperature, 4-chloro-6- methoxy-7-(3-moφholinopropoxy)quinazoline (200mg, 5.9mmol), (prepared as described for the starting material in Example 3), in DMF (7ml) was added and the reaction mixture was degassed again before being heated at 100°C for 1 hour. Upon cooling to ambient temperature, the DMF was removed by evaporation and the residue taken up in methylene chloride (20ml) and methanol (20ml). Silica was added to this solution and the volatiles were removed by evaporation. The free flowing powder was placed on the top of a flash chromatography column pre-equilibrated in 100% methylene chloride. Elution was done using methylene chloride/methanol (a gradient of 100/0 to 10/1). The product was triturated with methanol and collected by filtration to give 4-(4-aza-6-trifluoromethyloxindol-3-yl) 6- methoxy-7-(3-morpholinopropoxy)quinazoline (35mg, 12%) as an orange solid. 1H NMR Spectrum: (DMSOd 6 , TFA) 2.3(m, 2H); 3.1(m, 2H); 3.3(m, 2H); 3.5(d, 2H); 3.65(t, 2H); 4.0(m, 5H); 4.3(m, 2H); 7.3(s, IH); 7.46(s, IH); 8.24(s, IH); 8.94(s, IH); 9.7(s, IH); 10.08(s, IH); 11.30(s, IH) MS - ESI: 504 [MH] + The starting material was prepared as follows: Sodium hydride (880mg, 20mmol) was added to dibenzyl malonate (5.5ml, 20mmol) in anhydrous DMF (35ml) at ambient temperature. The mixture was stirred for 15 minutes and 2-chloro-2-nitro-5-trifluoromethyl pyridine (2.5g, lOmmol, in 5ml of DMF) was added and the reaction mixture stirred at ambient temperature for 1 hour. The dark red solution was then poured into ice/water and extracted with ether (500ml). The ether phase was washed with water (4x250ml), brine, dried (MgSO 4 ), filtered and the volatiles removed by evaporation to give a red oil. Purification by flash chromatography using isohexanes/ethyl acetate (12/1) gave dibenzyl (3-nitro-5-trifluoromethyl-2-pyridyl) malonate as a white solid (3.5g, 67%). Dibenzyl (3-nitro-5-trifluoromethyl-2-pyridyl) malonate (3.5g, 7.4mmol) was dissolved in DMSO, and lithium chloride (620mg, 14mmol) and water (130mg, 7.4mmol) were added. The reaction mixture was heated at 100°C for 3 hours then left to cool to ambient temperature. The solution was diluted with ethyl acetate (500ml) and washed with water and brine, dried (MgSO 4 ) and the volatiles were removed by evaporation. Purification by flash chromatography using isohexanes/ethyl acetate (17/1) gave benzyl (3-nitro-5- trifluoromethyl-2-pyridyl) acetate (2.45g, 70%) as a pink solid. Benzyl (3-nitro-5-tiifluoromethyl-2-pyridyl) acetate (2.4g, 7.1mmol) was dissolved in acetic acid (15ml), iron powder (1.58g, 28mmol) was added and the mixture heated at 100°C for 1 hour. The reaction mixture was allowed to cool to ambient temperature, it was diluted with methanol and ethyl acetate and the iron salts were removed by filtration. Silica was added to the filtrate and the volatiles were removed by evaporation. The free flowing powder was placed on the top of a flash chromatography column pre-equilibrated in methylene chloride and the product was eluted using methylene chloride/methanol (25/1). Removal of the volatiles by evaporation, trituration of the solid with ether and filtration gave 4-aza-6-trifluoromethyloxindole (376mg, 26%). *H NMR Spectrum: (DMSOd 6 , TFA) 5.8 (s, IH); 7.9 (s, IH); 8.56 (s, IH); 12.58 (s, IH) Example 8 Using a procedure analogous to that described for the synthesis of Example 9, 4- methylsulphanyl-7-(3-moφholinopropoxy)quinazoline (160mg, 0.5mmol) was reacted with 7- aza-6-chlorooxindole (185mg, 1.1 mmol), (prepared as described for the starting material in Example 9), in DMSO (3ml) to give 4-(7-aza-6-chlorooxindol-3-yl)-7-(3- morpholinopropoxy)quinazoline hydrochloride (150mg, 64%). Η NMR Spectrum: (DMSOd 6 , CF 3 COOD) 2.2-2.3(m, 2H); 3.05-3.15(1, 2H); 3.35(t, 2H); 3.52(d, 2H); 3.75(t, 2H); 4.0(d, 2H); 4.28(t, 2H); 7.02(d, IH); 7.25(s, IH); 7.25(dd, IH); 8.0(d, IH); 8.55(br s, IH); 8.62(s, IH) MS - ESI: 440 [MH] + The starting material was prepared as follows: A suspension of 7-benzyloxy-3,4-dihydroquinazolin-4-one (7g, 28mmol), (prepared as described for the starting material in Example 6), in pyridine (350ml) containing phosphorus pentasulphide (12.5g, 33mmol) was heated at reflux for 8 hours. After cooling, the mixture was poured into water (1 litre). The precipitate was collected by filtration, and washed with water. The solid was dissolved in 6M sodium hydroxide and the solution was filtered. The filtrate was acidified to pH2 with 6M hydrochloric acid. The precipitate was collected by filtration, washed with water, and dried under vacuum at 60°C to give 7-benzyloxy-3,4- dihydroquinazolin-4-thione (7.42g, 99%). 1H NMR Spectrum: (DMSOd 6 ) 5.32(s, 2H); 7.25(d, IH); 7.32(dd, IH); 7.4(m, IH); 7.45(t, 2H); 7.55(d, 2H); 8.15(s, IH); 8.5(d, IH) MS - ESI: 269 [MH] + Methyl iodide (0.97ml, 15.4mmol) was added dropwise to a solution of 7-benzyloxy- 3,4-dihydroquinazolin-4-thione (3.45g, 12.9mmol) in THF (13ml) containing 1M sodium hydroxide (25.7ml). After stirring for 30 minutes at ambient temperature, the mixture was adjusted to pH7 with 2M hydrochloric acid. After dilution with water, the solid was collected by filtration, washed with water and dried under vacuum to give 7-benzyloxy-4- methylsulphanylquinazoline (3.3g, 92%). 1H NMR Spectrum: (DMSOd 6 ) 2.67(s, 3H); 5.32(s, 2H); 7.3-7.45(m, 5H); 7.5(d, 2H); 8.05(d, IH); 8.9(s, IH) MS - ESI: 283 [MH] + A solution of 7-benzyloxy-4-methylsulphanylquinazoline (3g, lO.όmmol) in TFA (30ml) was heated at reflux for 5 hours. After cooling, the volatiles were removed by evaporation. The residue was suspended in water and solid sodium hydrogen carbonate was added until complete dissolution. After extraction with ether, the aqueous layer was acidified to pH2 with 2M hydrochloric acid. The precipitate was collected by filtration, washed with water, followed by ether and dried under vacuum to give 7-hydroxy-4- methylsulphanylquinazoline (2g, quant.). 1H NMR Spectrum: (DMSOd 6 ) 2.7(s, 3H); 7.15(d, IH); 7.25(dd, IH); 8.0(d, IH); 8.9(s, IH) MS - El: 222 [M.] + 7-Hydroxy-4-methylsulphanylquinazoline (2.5g, 13mmol) was suspended in methylene chloride (65ml), triphenylphosphine (4.45g, 17mmol) was added followed by 4-(3- hydroxypropyl)moφholine (2.47g, 17mmol), (Bull Soc. Chim. Fr. 1962, 1117), and diethyl azodicarboxylate (2.92g, 17mmol) dropwise. After stirring for 1 hour the volatiles were removed by evaporation and the residue was partitioned between ethyl acetate/ether (20ml/20ml) and 1M hydrogen chloride (20ml). The aqueous layer was separated and adjusted to pH9 with solid sodium hydrogen carbonate. The aqueous layer was extracted with methylene chloride. The organic layer was separated, washed with water, brine and dried (MgSO 4 ). The volatiles were removed by evaporation and the residue was purified by chromatography eluting with methylene chloride/ethyl acetate/methanol (6/3/1 followed by 5/3/2 and 75/0/25) to give 4-methylsulphanyl-7-(3-moφholinopropoxy)quinazoline (2.03g 49%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 2.2-2.3(m, 2H); 2.7(s, 3H); 3.05-3.25(-m, 2H); 3.35(t, 2H); 3.55(d, 2H); 3.7(t, 2H); 4.05(d, 2H); 4.32(t, 2H); 7.38(d, IH); 7.4(s, IH); 8.1(d, IH); 9.05(d, IH) MS - El: 320 [MH] + Example 9 7-Aza 6-chlorooxindole (148mg, 0.88mmol) was added to a suspension of sodium hydride (40mg, lmmol, prewashed with hexane) in DMSO (2ml). After stirring for 15 minutes at ambient temperature, 7-(2-(2-methoxyethoxy)ethoxy)-4- methylsulphanylquinazoline (118mg, 0.4mmol) was added. After heating for 1.5 hours at 105°C, the volatiles were removed by evaporation. The residue was partitioned between ethyl acetate/ether (3ml/3ml) and saturated aqueous ammonium chloride. The emulsion was filtered. The solid was dissolved in methylene chloride/methanol and the volatiles were removed by evaporation. The residue was purified by chromatography eluting with methylene chloride/methanol (90/10) and the solvents were removed by evaporation. The solid was dissolved in methylene chloride/methanol (1/1) and 3M hydrogen chloride in ether (1ml) was added. After removal of the volatiles, the residue was collected by filtration, washed with ether and dried under vacuum to give 4-(7-aza-6-chlorooxindol-3-yI)-7-(2-(2- methoxyethoxy)ethoxy)quinazoline hydrochloride (90mg, 54%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 3.25(s, 3H); 3.5(t, 2H); 3.65(t, 2H); 3.85(t, 2H); 4.3(t, 2H); 7.01(d, IH); 7.15(s, IH); 7.3(dd, IH); 8.0(d, IH); 8.5(d, IH); 8.65(s, IH) MS - ESI: 415 [MH] + Elemental analysis: Found C 53.9 H 4.6 N 12.8% C 20 Hι 9 N 4 O 4 Cl 0.92HC1 Requires C 53.6 H 4.5 N 12.5% The starting material was prepared as follows: Pyridinium bromide perbromide (6.3g, 20mmol) was added to a solution of 7-aza-6- chloroindole (lg, 6.6mmol), (Synthesis 1992, 661), in 2-methyl-2-propanol (50ml) and the mixture was stirred at ambient temperature for 3.5 hours. The volatiles were removed by evaporation and the residue was partitioned between ethyl acetate and water. The organic layer was washed with water, brine and dried (MgSO 4 ) and the volatiles were removed by evaporation to give 7-aza-6-chloro-3,3-dibromo-l,3-dihydro-2H-indol-2-one (2. lg, 100%). 1H NMR Spectrum: (CDC1 3 ) 7.16(d, IH); 7.80(d, IH); 8.53(br s, IH) Zinc powder (4.3g, 66mmol) was added in portions with vigorous stirring to a solution of 7-aza-6-chloro-3,3-dibromo-l,3-dihydro-2H-indol-2-one (2.17g, 6.6mmol) in glacial acetic acid (40ml). After 30 minutes, the suspension was filtered, the residue was washed with acetic acid and the volatiles were removed under vacuum. The residue was suspended in water and the mixture was adjusted to pH6 with solid sodium hydrogen carbonate. The solid was collected by filtration, washed with water, followed by ether and dried under vacuum to give 7-aza-6-chlorooxindole (825mg, 75%). 1H NMR Spectrum: (DMSOd 6 ) 3.57(s, 2H); 7.03(d, IH); 7.59(d, IH); 11.2(br s, IH) MS - El: 168 [MH] + 7-Hydroxy-4-methylsulphanylquinazoline (4.8g, 25mmol), (prepared as described for the starting material in Example 8), was suspended in methylene chloride (100ml), triphenylphosphine (8.5 lg, 32.5mmol) was added, followed by 2-(2-methoxyethoxy)ethanol (3.9g, 32.5mmol), followed by diethyl azodicarboxylate (5.66g, 32.5mmol) dropwise. After stirring for 1 hour at ambient temperature, the volatiles were removed under vacuum. The residue was partitionned between ether and 1M hydrogen chloride. The aqueous layer was adjusted to pH7 with solid sodium hydrogen carbonate. The aqueous layer was extracted with a mixture of ether and ethyl acetate (1/1). The organic layer was dried (MgSO 4 ), filtered and the volatiles were removed by evaporation. The residue was purified by column chromatography eluting with methylene chloride/ethyl acetate (1/1) to give after evaporation of the solvent 7-(2-(2-methoxyethoxy)ethoxy)-4-methylsulphanylquinazoline (4.69g, 63%). 1H NMR Spectrum: (CDC1 3 ) 2.65(s, 3H); 3.30(s, 3H); 3.55(m, 2H); 3.65(m, 2H); 3.85(t, 2H); 4.25(t, 2H); 7.1-7.2(m, 2H); 7.9(d, IH); 8.85(s, IH) Example 10 5,7-Diaza-6-methyloxindole (131mg, O.88mmol), (prepared as described for the starting material in Example 6), was added to a suspension of sodium hydride (40mg, lmmol, prewashed with pentane) in DMF (3 ml). After stirring for 1 hour at ambient temperature 4- chloro-6-methoxy-7-(2-(l,2,3-triazol-l-yl)ethoxy)quinazoline (122mg, 0.4mmol) was added and the mixture was heated at 60°C for 2 hours. After cooling, the mixture was poured into water and adjusted to pH7 with 2M hydrochloric acid. The precipitate was collected by filtration, washed with ether and dried under vacuum. The solid was purified by column chromatography eluting with methylene chloride/methanol (90/10 followed by 80/20) to give, after removal of the volatiles by evaporation, an orange solid. The solid was dissolved in methylene chloride/methanol and 0.5ml of 3M hydrogen chloride in ether was added. After removal of the solvents, the residue was collected by filtration, washed with ether and dried under vacuum to give 4-(5,7-diaza-6-methyloxindol-3-yl)-6-methoxy-7-(2-(l,2,3-triazol-l- yl)ethoxy)quinazoline hydrochloride (40mg, 20%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 2.75(s, 3H); 3.95(s, 3H); 4.65(t, 2H); 4.95(t, 2H); 7.2(s, IH); 7.8(s, IH); 8.22(s, IH); 8.8(s, IH); 9.05(s, IH); 9.4-9.5(br s, IH) MS - ESI: 419 [MH] + Elemental analysis: Found C 46.3 H 4.2 N 21.6% C 2 oHι 8 N 8 θ 3 1.5H 2 O 2HCl Requires C 46.3 H 4.5 N 21.6% The starting material was prepared as follows: Triphenylphosphine (2.82g, 10.7mmol) was added to a solution of 2-(l,2,3-triazol-l- yl)ethanol (609mg, 5.4mmol), (J. Antib. 1993, 46, 177), and 7-hydroxy-6-methoxy-3- ((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (l.lg, 3.6mmol), (prepared as described for the starting material in Example 5), in methylene chloride (70ml), diethyl azodicarboxylate (600μl, 10.7mmol) was then added. After stirring for 2 hours at ambient temperature, the volatiles were removed by evaporation and the residue was purified by column chromatography eluting with methylene chloride/methanol (98/2) to give 6-methoxy-3- ((pivaloyloxy)methyl)-7-(2-(l,2,3-triazol-l-yl)ethoxy)-3,4-dihydroquinazolin-4-one (4g, 97%). 5.1M Ammonia in methanol (30ml) was added to a solution of 6-methoxy-3- ((pivaloyloxy)methyl)-7-(2-( 1 ,2,3-triazol- 1 -yl)ethoxy)-3,4-dihydroquinazolin-4-one ( 1.4g, 3.5mmol) in a solution of methanol (30ml). After stirring overnight at ambient temperature, the volatiles were removed by evaporation and the residue was triturated with ether, collected by filtration, washed with ether and dried under vacuum to give 6-methoxy-7-(2-( 1,2,3- triazol-l-yl)ethoxy)quinazoline (946mg, 92%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 3.9(s, 3H); 4.6(t, 2H); 4.9(t, 2H); 7.25(s, IH); 7.52(s, IH); 7-77(s, IH); 8.19(s, IH); 8.9(s, IH) MS - ESI: 170 [MH] + A solution of 6-methoxy-7-(2-(l,2,3-triazol-l-yl)ethoxy)quinazoline (920mg, 3.2mmol) in thionyl chloride (10ml) containing DMF (0.9ml) was heated at 80°C for 1 hour. After evaporation of the volatiles, the residue was azeotroped with toluene. The residue was partitioned between ethyl acetate and water and the aqueous layer was adjusted to pH8 with solid sodium hydrogen carbonate. The organic layer was washed with water, brine, dried (MgSO 4 ), and the volatiles were removed by evaporation. The residue was purified by column chromatography eluting with methylene chloride/methanol (96/4) to give 4-chloro-6- methoxy-7-(2-(l,2,3-triazol-l-yl)ethoxy)quinazoline (693mg, 71%). Η NMR Spectrum: (CDC1 3 ) 4.1(s, 3H); 4.55(t, 2H); 4.95(t, 2H); 7.3(s, IH); 7.4(s, IH); 7.75(s, IH); 7.95(s, IH); 8.85(s, IH) MS - El: 305 [MH] + Elemental analysis: Found C 51.0 H 4.0 N 22.6% Cι 3 Hι 2 N 5 O 2 Cl Requires C 51.0 H 3.9 N 22.9% Example 11 Under nitrogen, 5,7-diaza-6-methyloxindole (105mg, 0.70mmol), (prepared as described for the starting material in Example 6), in DMSO (2ml) was added dropwise to a suspension of sodium hydride (25mg, 0.70mmol ; prewashed with pentane). After stirring for 30 minutes at ambient temperature, 4-(2-methoxyethylsulphanyl)-7-(3- methylsulphonylpropoxy)quinazoline (lOOmg, 0.28mmol) was added. The mixture was heated at 100°C for 2.5 hours. After cooling, the mixture was poured onto a saturated aqueous solution of ammonium chloride (15ml). The precipitate was collected by filtration and purified by column chromatography eluting with methylene chloride/methanol (97/3 followed by 95/5 and 93/7) to give a solid. The solid was dissolved in methanol/methylene chloride (1/1) and 3.8M hydrogen chloride in ether (0.5ml) was added. After removal of the volatiles, the residue was triturated with ether, collected by filtration, washed with ether and dried under vacuum to give 4-(5,7-diaza-6-methyloxindoI-3-yl)-7-(3- methylsulphonylpropoxy)quinazoline hydrochloride (47 mg, 15%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 2.2-2.35(t, 2H); 2.75(s, 3H); 3.1(s, 3H); 3.35(t, 2H); 4.3(t, 2H); 7.05(s, IH); 7.25(d, IH); 8.75(s, IH); 9.05(s, IH); 9.6-9.7(br s, IH) MS - ESI: 414 [MH] + Elemental analysis: Found C 46.3 H 13.5 N 4.8% Cι 9 Hι 9 N 5 O 4 S 2.5H 2 O 1HC1 Requires C 46.1 H 14.1 N 5.1% The starting material was prepared as follows: 2-Bromoethyl methyl ether (3.2ml, 33mmol) was added dropwise to a solution of 7- benzyloxy-3,4-dihydroquinazolin-4-thione (7.4g, 28mmol), (prepared as described for the starting material in Example 8), in DMF (275ml) containing potassium carbonate (4.6g, 33mmol). After stirring for 4 hours, water was added and the precipitate was collected by filtration, washed with water, and dried under vacuum to give 7-benzyloxy-4-(2- methoxyethylsulphanyl)quinazoline (8g, 89%). 1H NMR Spectrum: (DMSOd 6 ) 3.3(s, 3H); 3.56(t, 2H); 3.64(t, 2H); 5.32(s, 2H); 7.35-7.5(m, 5H); 7.52(d, 2H); 8.05(d, IH); 8.9(s, IH) MS - ESI: 327 [MH] + A solution of 7-benzyloxy-4-(2-methoxyethylsulphanyl)quinazoline (8g, 24.5mmol) in TFA (80ml) was refluxed for 5 hours. After cooling and removal of the volatiles by evaporation, the residue was triturated with water, collected by filtration, washed with water and then ethyl acetate. The residue was resuspended in methylene chloride, filtered, washed with petroleum ether and dried under vacuum to give 7-hydroxy-4-(2- methoxyethylsulphanyl)quinazoline (5.8g, quant.). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 3.35(s, 3H); 3.7(s, 4H); 7.24(s, IH); 7.4(d, IH); 8.25(d, IH); 9.2(s, IH) MS - ESI: 237 [MH] + 3-Chloroperoxybenzoic acid (25g, 97.2mmol) was added in portions to a solution of 3- (methylsulphanyl)-l-propanol (5ml, 48.6mmol) in methylene chloride (100ml) while maintaining the reaction temperature at 25°C. After stirring for 1 hour at ambient temperature, the solid was removed by filtration and the filtrate was diluted with an aqueous solution of sodium sulphite (6.5g, 51.6mmol) in water (200ml). The organic layer was separated and the volatiles were removed by evaporation. The white residue was triturated with acetone and the volatiles were again removed by evaporation. The solid was then dissolved in methylene chloride and aluminum oxide (9θA mesh) was added. After standing for 15 minutes, the solid was removed by filtration and the volatiles were removed by evaporation to give 3-(methylsulphonyl)-l-propanol as a colourless oil (4.46g, 66%). Η NMR Spectrum: (CDC1 3 ) 1.9-2.1(br s, IH); 2.15(m, 2H); 2.95(s, 3H); 3.2(t, 2H); 3.85(t, 2H) MS - El: 139 [MH]+ A solution of 7-hydroxy-4-(2-methoxyethylsulphanyl)quinazoline (0. lg, 3.8mmol) in methylene chloride (20ml) containing triphenylphosphine (1.7g, 6.36mmol), 3- (methylsulphonyl)-l-propanol (0.85g, 6mmol) and diethyl azodicarboxylate (1.05ml, 6.36mmol) was stirred for 3 hours at ambient temperature. After partial evaporation of the methylene chloride, ethyl acetate was added. The precipitate was collected by filtration, washed with ether and dried under vacuum to give 4-(2-methoxyethylsulphanyl)-7-(3- methylsulphonylpropoxy)quinazoline (960mg, 71%). Η NMR Spectrum: (DMSOd 6 , CF 3 COOD) 2.2-2.35(m, 2H); 3.05(s, 3H); 3.3(s, 3H); 3.35(t, 2H); 3.64(d, 2H); 3.67(d, 2H); 4.35(t, 2H); 7.35(d, IH); 7.42(dd, IH); 8.15(d, IH); 9.1(s, IH) MS - ESI: 379 [MNa] + Example 12 5,7-Diaza-6-methyloxindole (215mg, 1.44mmol), (prepared as described for the starting material in Example 6), in DMSO (2.5ml) was added dropwise to a suspension of sodium hydride (58mg, 1.44mmol, prewashed with pentane) in DMSO (1ml). After stirring for 30 minutes at ambient temperature, 7-(2-(2-methoxyethoxy)ethoxy)-4- methylsulphanylquinazoline (140mg, 0.578mmol), (prepared as described for the starting material in Example 9), was added. After heating for 2 hours at 105°C, the mixture was poured onto methylene chloride/saturated aqueous ammonium chloride (40ml/40ml). The organic layer was separated and the aqueous layer was extracted with methylene chloride. The organic layer were combined, washed with brine, dried (MgSO 4 ), filtered and the volatiles were removed by evaporation. The residue was purified by column chromatography eluting with methylene chloride/methanol (95/5 followed by 94/6). After partial removal of the solvent, 3.8M hydrogen chloride in ether (1ml) was added. After removal of the volatiles by evaporation, the solid was triturated with ether, collected by filtration, washed with ether and dried under vacuum to give 4-(5,7-diaza-6-methyloxindol-3-yl)-7-(2-(2- methoxyethoxy)ethoxy)quinazoline hydrochloride (72mg, 28%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 2.7(s, 3H); 3.26(s, 3H); 3.45(t, 2H); 3.65(t, 2H); 3.85(t, 2H); 4.30(t, 2H); 7.1(d, IH); 7.25(dd, IH); 8.75(s, IH); 9.05(s, IH); 9.6-9.7(br s, IH) MS-ESI: 396 [MH] + Elemental analysis: Found C 53.7 H 5.3 N 15.8% C 2 oH 2 ιN 5 O 4 lH 2 O 1HC1 Requires C 53.4 H 5.4 N 15.6% Example 13 Using a procedure similar to the one described for the synthesis of Example 12, 5,7- diaza-6-methyloxindole (167mg, l.lmmol), (prepared as described for the starting material in Example 6), in DMF (4ml) was added to sodium hydride (45mg, l.lmmol) in DMF (1ml) and the solution was reacted with 4-chloro-6-methoxy-7-(2-(2-methoxyethoxy)ethoxy)quinazoline (140mg, 0.45 mmol) to give after work up, purification and hydrochloride salt formation 4- (5,7-diaza-6-methyloxindol-3-yl)-6-methoxy-7-(2-(2-methoxyethoxy)ethoxy)quinazoline hydrochloride (70mg, 32%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 2.7(s, 3H); 3.26(s, 3H); 3.5(t, 2H); 3.65(t, 2H); 3.85(t, 2H); 3.95(s, 3H); 4.32(t, 2H); 7.2(s, IH); 8.8(s, IH); 9.05(s, IH); 9.35-9.5(br s, IH) MS-ESI: 426 [MH] + Elemental analysis: Found C 51.2 H 5.6 N 14.4% C 2 ,H 23 N 5 O 5 1.6H 2 O 1.05HC1 Requires C 51.2 H 5.6 N 14.2% The starting material was prepared as follows: 7-Hydroxy-6-methoxy-3-((pivaloyloxy)methyl-3,4-dihydroquinazolin-4-one ( 1.2g, 3.9mmol), (prepared as described for the starting material in Example 5), was suspended in methylene chloride (70ml) cooled at 5°C and 2-(2-methoxyethoxy)ethanol (653μl, 5.5mmol) was added followed by triphenylphosphine (1.44g, 5.5mmol) and diethyl azodicarboxylate (864μl, 5.5mmol) dropwise. After stirring for 1.5 hours at ambient temperature, the volatiles were removed under vacuum. The residue was purified by column chromatography eluting with ethyl acetate/methylene chloride (1/1 followed by 80/20) to give, after removal of the volatiles by evaporation, 6-methoxy-7-(2-(2-methoxyethoxy)-ethoxy)-3-((pivaloyloxy)methyl- 3,4-dihydroquinazolin-4-one (1.6g, 95%). Η NMR Spectrum: (DMSOd 6 ) 1.2(s, 9H); 3.26(s, 3H); 3.5(t, 2H); 3.6(t, 2H); 3.8(t, 2H); 3.9(s, 3H); 4.25(t, 2H); 5.95(s, 2H); 7.2(s, IH); 7.5(s, IH); 8.4(s, IH) A solution of saturated ammonia in methanol (20ml) was added to a solution of 6- methoxy-7-(2-(2-methoxyethoxy)ethoxy)-3-((pivaloyloxy)methyl-3,4-dihydroquinazolin-4- one (2.26g, 5.5mmol) in a mixture of methylene chloride (15ml) and ethanol (40ml). After stirring for 24 hours at ambient temperature ammonia in methanol (20ml) was added and stirring was continued for a further 24 hours. The volatiles were removed under vacuum and the residue was triturated with ether, collected by filtration, washed with ether and dried under vacuum to give 6-methoxy-7-(2-(2-methoxyethoxy)ethoxy)quinazolin-4-one (975mg, 78%). 1H NMR Spectrum: (DMSOd 6 ) 3.25(s, 3H); 3.45(t, 2H); 3.6(t, 2H); 3.8(t, 2H); 3.85(s, 3H); 4.25(t, 2H); 7.15(s, IH); 7.45(s, IH); 7.95(s, IH) MS-EI: 294 [M.] + A solution of 6-methoxy-7-(2-(2-methoxyethoxy)ethoxy)quinazolin-4-one (930mg, 3.2mmol) in thionyl chloride (15ml) containing DMF (150μl) was heated at 60°C for 1.5 hours. The volatiles were removed by evaporation. The residue was dissolved in methylene chloride, the solution was cooled to 5°C and adjusted to pH8 by the addition of 5% aqueous sodium hydrogen carbonate solution. The organic layer was separated, washed with brine, dried (MgSO 4 ), filtered and the volatiles were removed under vacuum. The residue was purified by column chromatography eluting with ethyl acetate to give 4-chloro-6-methoxy-7- (2-(2-methoxyethoxy)ethoxy)quinazoline (863mg, 87%). Η NMR Spectrum: (DMSOd 6 ) 3.25(s, 3H); 3.45(t, 2H); 3.65(t, 2H); 3.85(t, 2H); 4.0(s, 3H); 4.35(t, 2H); 7.4(s, IH); 7.5(s, IH); 8.9(s, IH) Example 14 Using a procedure analogous to the one described for the synthesis of Example 10, 7- azaoxindole (147mg, l.lmmol), (prepared as described for the starting material in Example 2), in DMF (2.5ml) was added to sodium hydride (43.6mg, l.lmmol) in DMF (1.5ml) and the solution was reacted with 4-chloro-7-(3-moφholinopropoxy)quinazoline (134mg, 0.43 mmol), (prepared as described for the starting material in Example 6), to give after work up, purification and hydrochloride salt formation, 4-(7-azaoxindol-3-yl)-7-(3- morpholinopropoxy)quinazoline hydrochloride (147mg, 66%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 2.3(m, 2H); 3.15(t, 2H); 3.35(t, 2H); 3.55(d, 2H); 3.75(t, 2H); 4.05(d, 2H); 4.3(t, 2H); 7.15(s, IH); 7.2-7.3(m, 2H); 7.95(d, IH); 8.7(s, IH); 8.6- 8.8(br s, IH); 9-9.1 (br s, lH) MS-ESI: 406 [MH] + Elemental analysis: Found C 51.8 H 5.4 N 13.7% C 22 H 23 N 5 O 3 2H 2 O 1.95HCl Requires C 51.5 H 5.7 N 13.7% Example 15 Using a procedure analogous to the one described for the synthesis of Example 3, 7- azaoxindole (191mg, 1.43mmol), (prepared as described for the starting material in Example 2), in DMSO (2ml) was added to sodium hydride (57mg, 1.4mmol) in DMSO (1ml) and the solution was reacted with 7-(2-(2-methoxyethoxy)ethoxy)-4-methylsulphanyl-quinazoline (140mg, 0.47mmol), (prepared as described for the starting material in Example 9), at 110°C for 40 minutes to give after work-up, purification, and hydrochloride salt formation 4-(7- azaoxindoI-3-yl)-7-(2-(2-methoxyethoxy)ethoxy)quinazoline hydrochloride (118mg, 56%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 3.25(s, 3H); 3.5(t, 2H); 3.65(t, 2H); 3.85(t, 2H); 4.35(t, 2H); 7.15(s, IH); 7.25-7.3(m , 2H); 7.95(d, IH); 8.7(s, IH); 8.65-8.8(br s, IH); 8.95- 9.1(br s, IH) MS-ESI: 381 [MH] + Elemental analysis: Found C 54.2 H 5.3 N 12.8% C 2 oH 20 N 4 O 4 1.15H 2 O 1.22HC1 Requires C 53.9 H 5.3 N 12.5% Example 16 Using a procedure analogous to the one described for the synthesis of Example 3, 7- azaoxindole (171mg, 1.27mmol), (prepared as described for the starting material in Example 2), in DMSO (2ml) was added to sodium hydride (51mg, 1.3mmol) in DMSO (1ml) and the solution was reacted with 4-methylsulphanyl-7-(4-moφholinobut-2-yn-l-yloxy)quinazoline (140mg, 0.425mmol) to give after work up, purification and hydrochloride salt formation, 4- (7-azaoxindoI-3-yl)-7-(4-morpholinobut-2-yn-l-yloxy)quinazoline hydrochloride ( 138mg, 57%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 3.05-3.2(br s, 2H); 3.4-3.5(br s, 2H); 3.65-3.8(br t, 2H); 3.9-4.0(br s, 2H); 4.3(s, 2H); 5.2(s, 2H); 7.2-7.35(m, 3H); 7.95(d, IH); 8.7(s, IH); 8.7- 8.8(br s, IH); 9.0-9. l(br s, lH) MS-ESI: 416 [MH] + The starting material was prepared as follows: Triphenylphosphine (4.09g, 1.56mmol) was added dropwise to a solution of 7- hydroxy-4-methylsulphanylquinazoline (1.2g, 6.25mmol), (prepared as described for the starting material in Example 8), in methylene chloride (30ml), followed by 4-moφholinobut- 2-yn-l-ol (1.26g, 8.3mmol), (J. Am. Chem. Soc. 1957, 79, 6184), in methylene chloride (5ml) and diethyl azodicarboxylate (2.46ml, 1.56mmol) was added dropwise. After stirring for 3 hours at ambient temperature, the volatiles were removed under vacuum and the residue was purified by column chromatography eluting with methylene chloride/methanol (100/0 followed by 95/5). After removal of the solvent, the residue was triturated with ether, collected by filtration and dried under vacuum to give 4-methylsulphanyl-7-(4- morpholinobut-2-yn-l-yloxy)quinazoline (1.3g, 63%). 1H NMR Spectrum: (CDC1 3 ) 2.5(t, 4H); 2.7(s, 3H); 3.32(t, 2H); 3.7(t, 4H); 4.9(t, 2H); 7.2(d, IH); 7.35(d, IH); 8.0(d, IH); 8.9(s, IH) MS-ESI: 330 [MH] + Example 17 Using a procedure analogous to the one described for the synthesis of Example 3, 7- azaoxindole (146mg, 1.09mmol), (prepared as described for the starting material in Example 2), in DMSO (20ml) was added to sodium hydride (43.5mg, 1.09mmol) in DMSO (0.5ml) and the solution was reacted with 4-methylsulphanyl-7-(4-moφholinobut-2-en-l- yloxy)quinazoline (120mg, 0.36mmol) to give after work up, purification and hydrochloride salt formation, 4-(7-azaoxindol-3-yl)-7-(4-morpholinobut-2-en-l-yloxy)quinazoline hydrochloride (lOOmg, 49%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 3.05(t, 2H); 3.35(d, 2H); 3.7(t, 2H); 3.85(d, 2H); 4.0(d, 2H); 4.9(d, 2H); 6.0(td, IH); 6.25(td, IH); 7.2(s, IH); 7.25-7.35(m, 2H); 7.95(d, IH); 8.7(s, IH); 8.7-8.8(br s, IH); 9.0-9. l(br s, IH) MS-ESI: 418 [MH] + Elemental analysis: Found C 49.0 H 5.4 N 12.4% C 23 H 23 N 5 O 3 2.5H 2 O 2.8HC1 Requires C 48.9 H 5.5 N 12.4% The starting material was prepared as follows: Using a procedure analogous to the one described for the synthesis of the starting material in Example 16, 4-moφholinobut-2-en-l-ol (1.27g, 8.13mmol), (J. Med. Chem. 1972, 15, 110-112), was reacted with 7-hydroxy-4-methylsulphanylquinazoline (1.2g, 6.25mmol), (prepared as described for the starting material in Example 8), in methylene chloride (30ml) in the presence of triphenylphosphine (4.09g, 1.56mmol) and diethyl azodicarboxylate (2.46ml, 1.56mmol) to give 4-methylsulphanyl-7-(4-moφholinobut-2-en-l-yloxy)quinazoline (1.15g, 55%). 1H NMR Spectrum: (CDC1 3 ) 2.45(br s, 4H); 2.7(s, 3H); 3.05(d, 2H); 3.7(t, 4H); 4.7(d, 2H); 5.9(m, 2H); 7.15-7.25(m, 2H); 7.95(d, IH); 8.9(d, IH) MS-ESI: 332 [MH] + Example 18 A solution of 4-azaoxindole (268mg, 2mmol) in DMF (2.5ml) was added to sodium hydride (80mg, 2mmol) in DMF (1.5ml) and the solution was reacted with 4-chloro-7-(3- moφholinopropoxy)quinazoline (201mg, 0.65mmol), (prepared as described for the starting material in Example 6), in DMF (2ml). After stirring for 45 minutes at 75°C, the solvent was removed by evaporation. The residue was purified by column chromatography eluting with methylene chloride/methanol (93/7) to give, after evaporation of the solvent and hydrochloride salt formation (as described in Example 3), 4-(4-azaoxindol-3-yl)-7-(3- morpholinopropoxy)quinazoline hydrochloride (93mg, 10%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 2.35(m, 2H); 3.15(m, 2H); 3.35(m, 2H); 3.52(d, 2H); 3.70(t, 2H); 4.0(d, 2H); 4.40(t, 2H); 7.20(m, IH); 7.42(dd, IH); 7.70(m, 2H); 7.8(t, IH); 8.25(m, IH); 9.40(s, IH) MS (ESI): 406 [MH] + Elemental analysis: Found C 50.9 H 5.6 N 13.4% C 22 H 23 N 5 O 3 2.5H 2 O 1.9HCl Requires C 50.8 H 5.8 N 13.5% The starting material was prepared as follows: Sodium hydride (5.65g, 130mmol) was suspended in anhydrous DMF (100ml) and diethyl malonate (19.15ml, 130mmol) was added dropwise over a 30 minute period. The reaction was stirred for 30 minutes after which 2-chloro-3-nitropyridine (9.9g, 62.4mmol) was added in one portion giving an instant red colour to the reaction mixture. After 3 hours at ambient temperature the DMF was evaporated off under vacuum and the residue purified by flash chromatography using increasingly polar solvent mixtures using first isohexane and ending with isohexane/ethyl acetate (3/2). Evaporation of the solvent gave 2-(3-nitro-2- pyridyl)diethyl malonate (1 lg, 62%) as a yellow oil. MS (ESI): [MHT281 2-(3-Nitro-2-pyridyl)diethyl malonate (16g, 57mmol) was dissolved in DMSO (250ml). Lithium chloride (4.8g, 113mmol) and water (1.02g, 57mmol) were added and the mixture was stirred at 120°C for 5 hours. The reaction was allowed to cool to ambient temperature and diluted with ethyl acetate (500ml). The organic phase was washed with brine (2x500ml), dried (MgSO 4 ), filtered and evaporated. The resulting oil was purified by flash chromatography using isohexanes/ethyl acetate (1/1) as the eluent to give 2-(3-nitro-2- pyridyl)ethyl acetate (11.2g, 94%) as a red oil. A mixture of 2-(3-nitro-2-pyridyl)ethyl acetate (10.1, 48mmol), tin(II)chloride dihydrate (54.3g, 240mmol) and ethyl acetate was stirred and heated at reflux for 5 hours. The reaction mixture was allowed to cool overnight, filtered through diatomaceous earth and the solvent was removed by evaporation. The resulting oil was purified by flash chromatography using increasingly polar solvent mixtures starting with methylene chloride and ending with methylene chloride/methanol (10/1). Removal of the solvent by evaporation gave 4-azaoxindole (2.1g, 33%). Η NMR Spectrum: (DMSOd 6 ) 3.35(br s, 2H); 7.15(m, 2H); 8.05(d, IH); 10.50(br s, IH) MS (ESI): [MH] + 133 Example 19 Sodium hydride (53mg, 1.3mmol) was washed with pentane then suspended in anhydrous DMSO (0.5ml). 5,7-Diaza-6-propyloxindole (234mg, 1.3mmol) in solution in DMSO (1.7ml) was added and the mixture was stirred for 10 minutes under argon. 4- Methylsulphanyl-7-(2-(2-methoxyethoxy)ethoxy)quinazoline (130mg, 0.44mmol), (prepared as described for the starting material in Example 9), was then added and the reaction mixture was stirred at 100°C for 4.5 hours. The solvent was then partially removed by rotary- evaporation and the residue was adsorbed onto silica and purified by flash chromatography using methylene chloride/methanol (95/5) as eluent. The product obtained was slightly impure and was further purified by flash chromatography using methylene chloride/acetonitrile/methanol (60/35/5) as eluent. The obtained solid was suspended in methylene chloride/methanol and treated with an ethereal solution of hydrogen chloride. The solvent was removed by evaporation to give 4-(5,7-diaza-6-propyloxindol-3-yl)-7-(2-(2- methoxyethoxy)ethoxy)quinazoline hydrochloride (125mg, 59%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 0.95(t, 3H); 1.85(m, 2H); 2.95(t, 2H); 3.25(s, 3H); 3.50(m, 2H); 3.65(m, 2H); 3.85(m, 2H); 4.35(m, 2H); 7.1(d, IH); 7.25(dd, IH); 8.75(s, IH); 9.05(s, IH); 9.65(br s, IH) MS (ESI): 424 [MH] + Elemental analysis: Found C 55.3 H 6.0 N 14.6% C 22 H 25 N 5 O 4 0.7H 2 O 1.1HC1 Requires C 55.3 H 5.8 N 14.7% The starting material was prepared as follows: Hydrogen chloride gas (~ 7.4g, 200mmol) was bubbled for 45 minutes through a mixture of butyronitrile (lOg, 145mmol) and absolute ethanol (8.65ml, 148mmol) cooled to - 5°C. The solution was kept at the same temperature for a further 2 hours then kept for 3 days in a cold room at 4°C to produce a viscous oil. To the viscous oil a solution of ammonia in ethanol (8% w/w, 35ml) was added. The reaction gave an exotherm and ammonium chloride precipitated out. The precipitate was removed by filtration and more ammonia in ethanol was added (100ml). The colourless solution was stirred overnight at ambient temperature. The solution was concentrated by rotary evaporation then cooled in an ice bath to give butamidine hydrochloride which was collected by filtration and washed with ether (9.88g, 55%, hygroscopic solid). Sodium hydride (2.85g, 71mmol) was washed with pentane then suspended in toluene (128ml). Diethyl succinate (11.5g, 66mmol) was added (strong exotherm) followed 5 minutes later by ethyl formate (6.6ml, 82mmol). The reaction mixture was stirred for 45 minutes at ambient temperature. Isopropanol (70ml) and butamidine hydrochloride (8.1g, 66mmol) were added and the mixture was heated at reflux for 3 hours. The solvent was removed by evaporation and the residue was dissolved in methylene chloride (150ml) and methanol (600ml). Silica was added and the solvent was removed by rotary evaporation. The powder obtained was placed on the top of a flash chromatography column and the product eluted using methylene chloride/methanol (95/5) to give ethyl (4-hydroxy-2-propylpyrimidin-5-yl) acetate (5.35g, 36%) as a white solid. Using a procedure analogous to the one described for the synthesis of the starting material in Example 6, ethyl (4-hydroxy-2-propylpyrimidin-5-yl) acetate (3g, 13mmol) was converted into ethyl (4-chloro-2-propylpyrimidin-5-yl) acetate (3.2g, 99%). Using a procedure analogous to the one described for the synthesis of the starting material in Example 6, ethyl (4-chloro-2-propylpyrimidin-5-yl) acetate (3.2g, 13mmol) was reacted with sodium azide to give, after purification by flash chromatography (petroleum ether/ether, 1/1), ethyl (4-azido-2-propylpyrimidin-5-yl) acetate (2.87g, 88%). Using a procedure analogous to the one described for the synthesis of the starting material in Example 6, ethyl (4-azido-2-propylpyrimidin-5-yl) acetate (2.85g, 11.4mmol) was hydrogenated at 1.2 atmospheres at ambient temperature over 1.5 hours to give ethyl (4- amino-2-propylpyrimidin-5-yl) acetate (2.36g, 93%). MS (ESI): [MH] + 224 Ethyl (4-amino-2-propylpyrimidin-5-yl) acetate (lg, 4.5mmol) was dissolved in diphenyl ether (4ml) and heated to 220-240°C under argon for 3 hours. The partially-cooled solution (120°C) was diluted with toluene (14ml) then left to return to ambient temperature and petroleum ether (50ml) was added. The formed precipitate was collected by filtration, washed with petroleum ether and redissolved in methylene chloride/methanol. To this solution, silica was added and the solvent was removed by rotary evaporation. The resulting powder was placed on the top of a silica column and the product was eluted off using methylene chloride/methanol (96/4) as the eluent. Removal of the solvent by evaporation gave 5,7-diaza-6-propyloxindole (307mg, 38%) as a beige solid. 1H NMR Spectrum: (DMSOd 6 ) 0.90(t, 3H); 1.75(q, 2H); 2.75(t, 2H); 3.55(s, 2H); 8.25(s, IH); 11.3(br s, IH) Example 20 Using a procedure analogous to the one described for the synthesis of Example 19, 4- aza-oxindole (153mg, 1.14mmol), (prepared as described for the starting material in Example 18), was added to sodium hydride (123mg, 3mmol) in DMSO (4ml) and the solution was reacted with 4-methylsulphanyl-7-(2-(2-methoxyethoxy)ethoxy)quinazoline (223mg, 0.76mmol), (prepared as described for the starting material in Example 9), to give after work- up, purification and hydrochloride salt formation, 4-(4-azaoxindol-3-yl)-7-(2-(2- methoxyethoxy)ethoxy)quinazoline hydrochloride (57mg, 16%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 3.25(s, 3H); 3.5(m, 2H); 3.65(m, 2H); 3.85(m, 2H); 4.35(m, 2H); 7.25(d, IH); 7.3(m, 2H); 7.5(d, IH); 8.0(d, IH); 8.9(s, IH); 10.1(d, IH) MS (ESI): 381 [MH] + Elemental analysis: Found C 50.8 H 5.5 N 11.5% C 20 H 20 N 4 O 4 2.8H 2 O 1.2HC1 Requires C 50.6 H 5.7 N l l.8% Example 21 Using a procedure analogous to the one described for the synthesis of Example 19, 5,7-diaza-6-propyloxindole (283mg, l.όmmol), (prepared as described for the starting material in example 19), was reacted with 4-methylsulphanyl-7-(3- moφholinopropoxy)quinazoline (170mg, 0.53mmol), (prepared as described for the starting material in Example 8), to give 4-(5,7-diaza-6-propyloxindol-3-yI)-7-(3- morpholinopropoxy)quinazoline hydrochloride (135mg, 47%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 0.95(t, 3H); 1.85(m, 2H); 2.45(m, 2H); 2.95(t, 2H); 3.15(m, 2H); 3.40(m, 2H); 3.55(m, 2H); 3.75(m, 2H);4.05(m, 2H); 4.30(m, 2H); 7.10(d, IH); 7.25(dd, IH); 8.75(s, IH); 9.05(s, IH); 9.65(br s, IH) MS (ESI): [MH] + 449 Elemental analysis: Found C 53.1 H 6.0 N 15.3% C 2 H 28 N 6 O 3 0.8H 2 O 2.2HC1 Requires C 53.1 H 5.9 N 15.5% Example 22 Sodium hydride (59mg, 1.46mmol, 60% in oil) was suspended in DMF (5ml) and DMSO (lml). 5,7-Diaza-6-methyloxindole (218mg, 1.46mmol), (prepared as described for the starting material in Example 6), was added in one portion and the solution was carefully degassed using alternatively vacuum and argon and stirred for 20 minutes at ambient temperature under argon. 7-(3-( 1 , 1 -Dioxothiomoφholino)propoxy)-4-(2- methoxyethylsulphanyl)quinazoline (200mg, 0.49mmol) was then added in one portion and the reaction mixture was stirred at 70°C for 5 hours. To complete the reaction the temperature was then raised to 100°C for 12 hours. After cooling the DMF was removed by evaporation under vacuum and the residue was redissolved using methanol, dichloromethane and triethylamine. Silica was added and the solvent was removed by evaporation. The resulting powder was placed on the top of a flash chromatography column pre-equilibrated with dichloromethane/triethylamine (95/5). Elution was done using increasingly polar solvent mixture up to dichloromethane/methanol/triethylamine (85/10/5). Removal of the solvent by evaporation gave 4-(5,7-diaza-6-methyloxindol-3-yl)-7-(3-(l,l- dioxothiomorpholino)propoxy)quinazoline (126mg, 56%). The hydrochloride salt was made by adding an ethereal solution of hydrogen chloride to the product in solution in dichloromethane/methanol follwed by removal of the solvent by evaporation and trituration in ether. 1H NMR Spectrum: (DMSOd 6 , CF3COOD) 2.30(m, 2H); 2.72(s, 3H); 3.50(m, 2H); 3.70(br s, 4H); 3.85(br s, 4H); 4.30(m, 2H); 7.12(d, IH); 7.25(dd, IH); 8.8(s, IH); 9.05(s, IH); 9.70(br s, IH) MS (ESI): 469 [MH] + Elemental analysis: Found C 47.0 H 5.3 N 15.3% C 22 H 24 N 6 O 3 1.5H 2 O 1.8HCl Et 3 NHC1 0.25 Requires C 47.4 H 5.5 N 14.7% The starting material was prepared as follows: A mixture of 3-amino-l-propanol (650μl, 8.4mmol) and vinyl sulphone (lg, 8.4mmol) was heated at 110°C for 45 minutes. The mixture was allowed to cool and was purified by column chromatography eluting with methylene chloride/methanol (95/5) to give 3-(l,l- dioxothiomoφholino)-l-propanol (800mg, 90%). 1H NMR Spectrum: (CDC1 3 ) 1.7-1.8(m, 2H); 2.73(t, 2H); 3.06(br s, 8H); 3.25(s, IH); 3.78(t, 2H) MS - ESI: 194 [MH] + Diethyl azodicarboxylate (lOOμl; 0.63mmol) was added dropwise to a solution of 7- hydroxy-4-(2-methoxyethylsulphanyl)quinazoline (lOOmg, 0.42mmol), (prepared as described for the starting material in Example 11), 3-(l,l-dioxothiomoφholino)-l-propanol (99mg, 0.51mmol) and triphenylphosphine (167mg, 0.63mmol) in methylene chloride (6ml). After stiring for 4 hours, triphenylphosphine (167mg, 0.63 mmol) and diethyl azodicarboxylate (lOOμl, 0.63mmol) were added and stirring was continued for 1 hour. The volatiles were removed by evaporation and the residue was purified by column chromatography eluting with ethyl acetate/methanol (100/0 followed by 92/8). After removal of the solvent by evaporation, the residue was triturated with ether and the solid was collected by filtration and dried under vacuum to give 7-(3-( 1 , 1 -dioxothiomoφholino)propoxy)-4-(2- methoxyethylsulphanyl)quinazoline (72mg, 41%). IH NMR Spectrum: (CDC1 3 ) 2.05(m, 2H); 2.7(t, 2H); 3.0-3. l(m, 8H); 3.42(s, 3H); 3.6(t, 2H); 3.72(t, 2H); 4.2(t, 2H); 7.15(dd, IH); 7.2(d, IH); 8.0(d, IH); 8.9(s, IH) MS-ESI: 434 [MNa]+ Example 23 5,7-Diaza-6-methyloxindole (440mg, 3mmol), (prepared as described for the starting material in Example 6), was dissolved in anhydrous DMF (15ml), the solution was degassed and sodium hydride (120mg, 3mmol) was added in one portion. The reaction mixture was degassed again and gave a green solution after 5 minutes at ambient temperature. Crude 4- chloro-6-methoxy-7-(2-(4-pyridyloxy)ethoxy)quinazoline was dissolved in DMF (10ml) and the solution was degassed prior to its addition to the oxindole anion solution. The reaction mixture was stirred at 95°C for 90 minutes, cooled to ambient temperature and the solvent was removed by evaporation. The residue was redissolved in a mixture of methylene chloride/methanol/ammonia (100/10/1) and 2g of silica were added. The solvent was removed by evaporation again, the free flowing powder was placed on the top of a silica column and the product was eluted off using the above solvent system. Evaporation of the solvent gave 210mg of the free base which was converted to the hydrochloride salt using an ethereal solution of hydrogen chloride to give 4-(5,7-diaza-6-methyloxindol-3-yl)-6- methoxy-7-(2-(4-pyridyloxy)ethoxy)quinazoline hydrochloride (145mg, 26%). 1H NMR Spectrum: (DMSOd 6 , CF3COOD) 2.7(s, 3H); 3.9(s, 3H); 4.6(m, 2H); 4.8(m, 2H); 7.2(s, IH); 7.65(d, 2H); 8.7(s, IH); 8.8(d, 2H); 8.9(s, IH); 9.4(br s, IH); 12.2(s, IH) MS (ESI): 445 [MH] + Elemental analysis: Found C 48.5 H 4.5 N 14.9% C 23 H 2 oN 6 O 4 2.7H 2 O 2HC1 Requires C 48.8 H 4.9 N 14.9% The starting material was prepared as follows: 4-Pyridyloxyethanol (3.5g, 25.2mmol), (J. Chem. Soc. Perk Trans 2, 1987, 1867), was suspended in methylene chloride (75ml) and triethylamine (2.6g, 26mmol) and tosyl chloride (4.7g, 0.25mmol) was added. The reaction mixture was stirred at ambient temperature for 10 minutes then washed with water and the organic phase was passed through a Bond Elute (Trade mark of Varian Associates Coφ.) column to remove any residual salts. The solvent was removed by evaporation and the residue was triturated with ether to give 2-(4- pyridyloxy)ethyl paratoluene sulphonate (3.94g, 53% yield). 4-Benzyloxy-5-methoxy-2-nitrobenzamide (26g, 91mmol), (J. Med. Chem.1977, vol 20, 146-149), was dissolved in TFA and heated at reflux for 2 hours. After cooling the TFA was removed by evaporation and the residue was stirred with 2M sodium hydroxide and insoluble material was removed by filtration. The red aqueous solution was acified to pHl with concentrated hydrochloric acid and allowed to cool back to ambient temperature before collecting the product by filtration. The obtained solid was washed with water and ether and dried in a vacuum oven at 60°C to give 4-hydroxy-5-methoxy-2-nitrobenzamide (11.04g, 62%). 4-Hydroxy-5-methoxy-2-nitrobenzamide (1.86g, 9.5mmol) and 2-(4-pyridyloxy)ethyl paratoluene sulphonate (3.3g, 11.2mmol) were mixed in the presence of potassium carbonate (1.7g, 12.3mmol) and anhydrous DMF (25ml) and heated at 80°C for 2 hours. The reaction mixture was allowed to cool overnight, the DMF was removed by evaporation and the residue was quenched into water (250ml). The solid was collected by filtration and washed with a mixture of acetone/ether (1/1) to give 5-methoxy-2-nitro-4-(2-(4- pyridyloxy)ethoxy)benzamide as a cream solid (2.16g, 68%). 5-Methoxy-2-nitro-4-(2-(4-pyridyloxy)ethoxy)benzamide (2.15g, 6.4mmol) and 10% palladium-on-charcoal catalyst (lOOmg) were suspended in methanol (400ml) and placed under hydrogen at atmospheric pressure. The reaction mixture was heated at 40°C for 1 hour, cooled to ambient temperature, filtered through diatomaceous earth and the solvent was removed by evaporation. The precipitate was slurried with ether and collected by filtration to give 2-amino-5-methoxy-4-(2-(4-pyridyloxy)ethoxy)benzamide as a cream solid (1.95g, 99%). 2-Amino-5-methoxy-4-(2-(4-pyridyloxy)ethoxy)benzamide (1.95g, 6.4mmol) and formamide (10ml) were heated at 190-200°C for 1 hour. The reaction mixture was allowed to cool to 50°C as the product precipitated out. Water (50ml) was added and the solid was collected by filtration, washed with more water and ether and dried under vacuum to give 6- methoxy-7-(2-(4-pyridyloxy)ethoxy)-3,4-dihydroquinazolin-4-one (0.99g, 49%) as a cream solid. The 6-methoxy-7-(2-(4-pyridyloxy)ethoxy)-3,4-dihydroquinazolin-4-one (312mg, lmmol) was heated at reflux in thionyl chloride (10ml) and DMF (5 drops) for 1 hour, then evaporated to dryness and partitioned between a saturated solution of sodium hydrogen carbonate and methylene chloride. The methylene chloride phase was dried by filtration through a phase separator paper and the solvent was removed by evaporation to give crude 4- chloro-6-methoxy-7-(2-(4-pyridyloxy)ethoxy)quinazoline which was used without further purification. Example 24 Using a procedure analogous to the one described for the synthesis of Example 23, 7- (2-(imidazol-l-yl)ethoxy)-6-methoxy-3,4-dihydroquinazoline-4-one (286mg, lmmol) was reacted with thionyl chloride (50ml) to give 4-chloro-7-(2-(imidazol-l-yl)ethoxy)-6- methoxyquinazoline which was then reacted with 5,7-diaza-6-methyloxindole (440mg, 3mmol) and sodium hydride (120mg, 3mmol) to give 4-(5,7-diaza-6-methyloxindol-3-yl)-7- (2-(imidazol-l-yl)ethoxy)-6-methoxyquinazoline hydrochloride (80mg, 15%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 2.7(s, 3H); 3.9(s, 3H); 4.2(m, 2H); 4.7(m, 2H); 7.2(s, IH); 7.7(s, IH); 7.8(s, IH); 8.7(s, IH); 9.0(s, IH); 9.2(s, IH); 9.4(br s, IH); 12.2(s, IH) MS (ESI): 418 [MHf Elemental analysis: Found C 48.8 H 4.4 N 18.8% C 2 ,Hι 9 N 7 O 3 1.5H 2 O 2HCl Requires C 48.8 H 4.7 N 19.0% The starting material was prepared as follows: Imidazole (20.4g, 300mmol) and ethylene carbonate (28.6g, 325mmol) were heated at 125°C for 1 hour. Once the CO 2 evolution had ceased the reaction mixture was allowed to cool to ambient temperature, was suspended in methylene chloride/methanol (10/1, 50ml) and was placed on the top of a short plug of silica. Elution was done using an increasingly polar solvent mixture of methylene chloride/methanol (100/10 up to 100/15). Removal of the solvent by evaporation gave crude 2-(imidazol-l-yl)ethanol (20. lg, 60%). A portion of the crude 2-(imidazol-l-yl)ethanol (lOg, 89mmol) and triethylamine (10. lg, lOOmmol) were dissolved in methylene chloride (250ml), tosyl chloride (17.5g, 92mmol) was added over 5 minutes as a solid, giving an exotherm to reflux. The reaction was stirred for 30 minutes at ambient temperature then quenched into 250ml of 1M hydrogen chloride and 250ml of methylene chloride. The organic phase was washed with brine and dried by passing it through a phase separator paper. Removal of the solvent by evaporation and purification by flash chromatography using methylene chloride/methanol/ammonia (100/10/1) gave 2-(imidazol-l-yl)ethyl paratoluene sulphonate (10.95g, 46%, impure). 4-Hydroxy-5-methoxy-2-nitrobenzamide (3g, 15.3mmol), (prepared as described for the starting material in Example 23), and 2-(imidazol-l-yl)ethyl paratoluene sulphonate (7g, impure) were mixed in the presence of potassium carbonate (5g, 72mmol) and anhydrous DMF (20ml) and heated at 100°C for 3 hours. The reaction mixture was allowed to cool to ambient temperature and the DMF was removed by evaporation. The residue was resuspended in methylene chloride/methanol/ammnonia (100/10/1) and silica (15g) was added. The solvent was removed by evaporation and the resulting powder was placed on the top of a silica gel column and eluted using first methylene chloride and slowly increasing the solvent polarity up to methylene chloride/methanol/ammnonia (100/10/1). Removal of the solvent by evaporation gave 4-(2-(imidazol-l-yl)ethoxy)-5-methoxy-2-nitrobenzamide as a cream solid (2.53g, 55%). Using a procedure analogous to the one described for the starting material in Example 23 , reduction of the nitro group of 4-(2-(imidazol- 1 -yl)ethoxy)-5-methoxy-2-nitrobenzamide (2.4g, 7.8mmol) gave 2-amino-4-(2-(imidazol-l-yl)ethoxy)-5-methoxybenzamide (2.12g, 98%). 2-Amino-4-(2-(imidazol-l-yl)ethoxy)-5-methoxybenzamide (2.10g, 7.6mmol) and formamide (10ml) were heated at 190-200°C for 3 hours. The reaction mixture was allowed to cool to ambient temperature and quenched into water (20ml). The precipitate was collected by filtration and washed with water and ether and dried under vacuum to give 7-(2-(imidazol- l-yl))-6-methoxy-3,4-dihydroquinazolin-4-one (1.42g, 65%). Example 25 Using a procedure analogous to the one described for the synthesis of Example 18, 5- azaoxindole (130mg, 0.97mmol), (Tet. 1993, 49, 2885), was reacted with 4-chloro-7-(3- moφholinopropoxy)quinazoline (234mg, 0.76mmol), (prepared as described for the starting material in Example 6), to give after work-up, purification and hydrochloride salt formation, 4-(5-azaoxindol-3-yl)-7-(3-morpholinopropoxy)quinazoline hydrochloride (112mg, 27%). 1H NMR Spectrum: (DMSOd 6 , CF 3 COOD) 2.25(m, 2H); 3.15(m, 2H); 3.35(m, 2H); 3.50(d, 2H); 3.75(t, 2H); 4.0(d, 2H); 4.30(t, 2H); 7.15(s, IH); 7.25(dd, IH); 7.30(d, IH); 8.35(d, IH); 8.75(s, IH); 9.30(s, IH); 9.55(d, IH) MS (ESI): 391 [MH] + Elemental analysis: Found C 47.5 H 5.4 N 12.5% C 22 H 23 N 5 O 3 3H 2 O 2.6HC1 Requires C 47.7 H 5.8 N 12.6% Example 26 The following illustrate representative pharmaceutical dosage forms containing the compound of formula I, or a pharmaceutically acceptable salt thereof (hereafter compound X), for therapeutic or prophylactic use in humans: (a) Tablet I mg/tablet Compound X 100 Lactose Ph.Eur 182.75 Croscarmellose sodium 12.0 Maize starch paste (5% w/v paste) 2.25 Magnesium stearate 3.0 (b) Tablet II mg/tablet Compound X 50 Lactose Ph.Eur 223.75 Croscarmellose sodium 6.0 Maize starch 15.0 Polyvinylpyrrolidone (5% w/v paste) 2.25 Magnesium stearate 3.0 (c) Tablet Ifl mg/tablet Compound X 1.0 Lactose Ph.Eur 93.25 Croscarmellose sodium 4.0 Maize starch paste (5% w/v paste) 0.75 Magnesium stearate 1.0 (d) Capsule mg/capsule Compound X 10 Lactose Ph.Eur 488.5 Magnesium stearate 1.5 (e) Injection I (50 mg/ml) Compound X 5.0% w/v IN Sodium hydroxide solution 15.0% v/v 0.1N Hydrochloric acid (to adjust pH to 7.6) Polyethylene glycol 400 4.5% w/v Water for injection to 100% (f) Injection II 10 mg/ml) Compound X 1.0% w/v Sodium phosphate BP 3.6% w/v 0.1N Sodium hydroxide solution 15.0% v/v Water for injection to 100% (g) Injection III (lmg/ml,buffered to pH6) Compound X 0.1% w/v Sodium phosphate BP 2.26% w/v Citric acid 0.38% w/v Polyethylene glycol 400 3.5% w/v Water for injection to 100% Note The above formulations may be obtained by conventional procedures well known in the pharmaceutical art. The tablets (a)-(c) may be enteric coated by conventional means, for example to provide a coating of cellulose acetate phthalate.

Claims: CLAIMS: 1. A compound of the formula I: (I) [wherein: ring Z is a 5 or 6-membered heterocyclic ring containing 1 to 3 heteroatoms selected independently from O, N and S with the proviso that the group at the 4-position of the quinazoline ring is not a substituted or unsubstituted group selected from 4,5,7-triazaoxindol- 3-yl and 4,6,7-triazaoxindol-3-yl; R 1 represents hydrogen, C )-4 alkyl, Cι- alkoxy methyl, di(Cι. 4 alkoxy)methyl or Cι -4 alkanoyl; R 2 represents hydroxy, halogeno, Cι -3 alkyl, Cι_ 3 alkoxy, d -3 alkanoyloxy, trifluoromethyl, 2,2,2-trifluoroethyl, cyano, amino, nitro, C 2-4 alkanoyl, Cι- alkanoylamino, Cι -4 alkoxycarbonyl, C) -4 alkylthio, Cι -4 alkylsulphinyl, Cι -4 alkylsulphonyl, carbamoyl, N- Cι- 4 alkylcarbamoyl, N,N-di(Cι -4 alkyl)carbamoyl, aminosulphonyl, N,N-di(Cι -4 alkyl)aminosulphonyl or Cι -4 alkylsulphonylamino or R is selected from one of the following four groups: 1) R 4 X* wherein X 1 represents a direct bond, -O-, -NR 5 -, Cι -3 alkyl, C 2 . 4 alkanoyl, - CONR 6 R 7 -, -SO 2 NR 8 R 9 - or -SO 2 R 10 - (wherein R 5 , R 6 and R 8 , each independently represents hydrogen or Cι -2 alkyl and R 7 , R 9 and R each independently represents Cι -4 alkyl and wherein R 4 is linked to R 7 , R 9 or R 10 ) and R 4 represents phenyl or a 5 or 6-membered heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group may be saturated or unsaturated and which phenyl or heterocyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, Cι_ 3 alkyl, C 1-3 alkoxy, Cι_ 3 alkanoyloxy, trifluoromethyl, cyano, amino, nitro and Cι_ 4 alkoxy carbonyl; 2) X 2 C 2-4 alkylX 3 Cι -3 alkyl (wherein X 2 is -O- or -NR 11 - (wherein R 11 is hydrogen, Cι -3 alkyl or Cι -3 alkoxyC 2-3 alkyl) and X 3 is -O-, -NR 12 -, -S-, -SO- or -SO 2 - (wherein R 12 is hydrogen, Cι -3 alkyl or Cι -3 alkoxyC 2-3 alkyl); 3) Cι -2 alkylX 4 C 2-3 alkylX 5 Cι -3 alkyl (wherein X 4 and X 5 which may be the same or different are each -O-, -S-, -SO-, -SO 2 - or -NR 13 - (wherein R 13 is hydrogen, Cι. alkyl or Cι. 3 alkoxyC 2-3 alkyl); and 4) Cι -3 alkylX 6 Cι -3 alkyl (wherein X 6 is -O-, -S-, -SO-, -SO 2 - or -NR 14 - (wherein R 14 is hydrogen, d -3 alkyl or Cι -3 alkoxyC 2-3 alkyl); n is an integer from 0 to 3 when Z is a 6-membered heterocyclic ring and n is an integer from 0 to 2 when Z is a 5-membered heterocyclic ring; m is an integer from 0 to 4; and R 3 represents hydroxy, halogeno, nitro, trifluoromethyl, d -3 alkyl, cyano, amino or R 15 X 7 (wherein X 7 represents a direct bond, -O-, -CH 2 -, -S-, -SO-, -SO 2 -, -NR 16 CO-, - CONR 17 -, -SO 2 NR 18 -, -NR 19 SO 2 - or -NR 20 - (wherein R 16 , R 17 , R 18 , R 19 and R 20 each independently represents hydrogen, Cι -3 alkyl or Cι -3 alkoxyC 2-3 alkyl), and R 15 is selected from one of the following seventeen groups: 1) hydrogen or Ci-salkyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy, fluoro and amino; 2) Cι -5 alkylX 8 COR 21 (wherein X 8 represents -O- or -NR 22 - (in which R 22 represents hydrogen, d. 3 alkyl or Cι -3 alkoxyC 2-3 alkyl) and R 21 represents d -3 alkyl, -NR 23 R 24 - or -OR 25 - (wherein R 23 , R 24 and R 25 which may be the same or different each represents hydrogen, Cι -3 alkyl or Cι -3 alkoxyC 2-3 alkyl)); 3) Cι -5 alkylX 9 R 26 (wherein X 9 represents -O-, -S-, -SO-, -SO 2 -, -OCO-, -NR 27 CO-, - CONR 28 -, -SO 2 NR 29 -, -NR 30 SO 2 - or -NR 31 - (wherein R 27 , R 28 , R 29 , R 30 and R 31 each independently represents hydrogen, Cι -3 alkyl or d -3 alkoxyC 2 . 3 alkyl) and R 26 represents hydrogen, Ci^alkyl, cyclopentyl, cyclohexyl or a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which Cj. 3 alkyl group may bear one or two substituents selected from oxo, hydroxy, halogeno and Cι -4 alkoxy and which cyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, Cι -4 alkyl, Cι. hydroxyalkyl and Cι -4 alkoxy); 4) Cι -5 alkylX 10 Cι -5 alkylX l l R 32 (wherein X 10 and X 1 1 which may be the same or different are each -O-, -S-, -SO-, -SO 2 -, -NR 33 CO-, -CONR 34 -, -SO 2 NR 35 -, -NR 36 SO 2 - or - NR 37 - (wherein R 33 , R 34 , R 35 , R 36 and R 37 each independently represents hydrogen, Cι -3 alkyl or Cι -3 alkoxyC 2-3 alkyl) and R 32 represents hydrogen or Cι -3 alkyl); 5) R 38 (wherein R 38 is a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, Cι -4 alkyl, Cι -4 hy droxy alkyl and Cι -4 alkoxy); 6) Cι -5 alkylR 38 (wherein R 38 is as defined herein); 7) C 2-5 alkenylR 38 (wherein R 38 is as defined herein); 8) C 2-5 alkynylR 38 (wherein R 38 is as defined herein); 9) R 39 (wherein R 39 represents a pyridone group, a phenyl group or a 5 or 6-membered aromatic heterocyclic group with 1 to 3 heteroatoms selected from O, N and S, which pyridone, phenyl or heterocyclic group may carry up to 5 substituents selected from hydroxy halogeno, amino, Cι -4 alkyl, Cι- alkoxy, Cι -4 hydroxyalkyl, Cι -4 aminoalkyl, d. 4 alkylamino, Cι- hydroxyalkoxy, carboxy, trifluoromethyl, cyano, -CONR 40 R 41 and -NR 42 COR 43 - (wherein R 40 , R 41 , R 42 and R 43 , which may be the same or different, each represents hydrogen, Cι -4 alkyl or Cι. 3 alkoxyC 2 . 3 alkyl)); 10) Cι- 5 alkylR 39 (wherein R 39 is as defined herein); 11) C 2-5 alkenylR (wherein R is as defined herein); 12) C 2 _ 5 alkynylR 39 (wherein R 39 is as defined herein); 13) Cι. 5 alkylX 12 R 39 (wherein X 12 represents -O-, -S-, -SO-, -SO 2 -, -NR^CO-, - CONR 45 -, -SO 2 NR 46 -, -NR 47 SO 2 - or -NR 48 - (wherein R 44 , R 45 , R 46 , R 47 and R 48 each iinnddeeppeenncdently represents hydrogen, Ci^alkyl or Cι_ 3 alkoxyC . 3 alkyl) and R 39 is as defined herein); 14) C 2 . 5 alkenylX 13 R 39 (wherein X 13 represents -O-, -S-, -SO-, -SO 2 -, -NR 49 CO-, - CONR 50 -, -SO 2 NR 51 -, -NR 52 SO 2 - or -NR 53 - (wherein R 49 , R 50 , R 51 , R 52 and R 53 each independently represents hydrogen, Cι. 3 alkyl or Cι. 3 alkoxyC 2 . 3 alkyl) and R is as defined herein); 15) C 2-5 alkynylX 14 R 39 (wherein X 14 represents -O-, -S-, -SO-, -SO 2 -, -NR 54 CO-, - CONR 55 -, -SO 2 NR 56 -, -NR 57 SO 2 - or -NR 58 - (wherein R 54 , R 55 , R 56 , R 57 and R 58 each independently represents hydrogen, d -3 alkyl or Cι -3 alkoxyC 2 - 3 alkyl) and R is as defined herein); 16) Cι -3 alkylX 15 C, -3 alkylR 39 (wherein X 15 represents -O-, -S-, -SO-, -SO 2 -, -NR 59 CO-, -CONR 60 -, -SO 2 NR 61 -, -NR 62 SO 2 - or -NR 63 - (wherein R 59 , R 60 , R 61 , R 62 and R 63 each independently represents hydrogen, or Cι -3 alkoxyC 2- 3alkyl) and R 39 is as defined herein); and 17) C 1-3 alkylX 15 Cι -3 alkylR 38 (wherein X 15 and R 38 are as defined herein))]; and salts thereof. 2. A compound as claimed in claim 1 wherein ring Z is a 6-membered heterocyclic ring containing 1 to 3 nitrogen atoms with the proviso that the group at the 4-position of the quinazoline ring is not a substituted or unsubstituted group selected from 4,5,7-triazaoxindol- 3-yl and 4,6,7-triazaoxindol-3-yl. 3. A compound as claimed in claim 1 wherein ring Z is a 6-membered heterocyclic ring containing 1 or 2 nitrogen atoms with the proviso that where R 2 is a group R 4 X [ , X 1 is not C 2-4 alkanoyl or -SO 2 R 10 - and R 4 is not optionally substituted phenyl or an optionally substituted 5or 6-membered unsaturated heterocyclic ring. A compound as claimed in any one of the preceding claims wherein R is hydrogen. 5. A compound as claimed in any one of the preceding claims wherein R 2 is halogeno, Cι_ 2 alkyl, Cι -2 alkoxy, trifluoromethyl, 2,2,2-trifluoroethyl, cyano, nitro, Cι -3 alkanoylamino, Cι -3 alkylsulphonyl, carbamoyl, N-Cι -3 alkylcarbamoyl, N,N-di(Cι -3 alkyl)carbamoyl, aminosulphonyl, N-Cι -3 alkylaminosulphonyl, N,N-di(Cι. 3 alkyl)aminosulphonyl or Cι -3 alkylsulphonylamino or R 2 is selected from one of the following four groups: 1) R 4 X' wherein X 1 represents -O-, -NR 5 -, C,. 3 alkyl, -CONR 6 R 7 - or -SO 2 NR 8 R 9 - (wherein R 5 , R 6 , and R 8 , each independently represents hydrogen or Cι -2 alkyl and R 7 and R 9 each independently represents and wherein R 4 is linked to R 7 or R 9 ) and R 4 represents a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group may bear two oxo substituents on a ring sulphur heteroatom; 2) X 2 C 2-3 alkylX 3 methyl (wherein X 2 is -O- or -NR 1 1 - (wherein R 1 1 is hydrogen or Cι -2 alkyl) and X 3 is -O-, -NR 12 - or -SO 2 - (wherein R 12 is hydrogen or C,_ 2 alkyl); 3) Cι -2 alkylX 4 C 2- alkylX 5 methyl (wherein X 4 and X 5 which may be the same or different are each -NR 13 - or -SO 2 - (wherein R 13 is hydrogen or Cι -2 alkyl); and 4) Cι -2 alkylX 6 Cι -2 alkyl (wherein X 6 is -O-, -NR 14 - or -SO 2 - (wherein R 14 is hydrogen or Cι -2 alkyl). 6. A compound as claimed in any one of the preceding claims wherein R is hydroxy, halogeno, nitro, trifluoromethyl, Cι. 3 alkyl, cyano, amino or R 15 X 7 [wherein X 7 is as defined in claim 1 and R 15 is selected from one of the following fifteen groups: 1) Cι_ 3 alkyl which may be unsubstituted or substituted with one or more fluorine atoms, or C 2-3 alkyl which may be unsubstituted or substituted with one or two groups selected from hydroxy and amino; 2) * 2-(3,3-dimethylureido)ethyl, 3-(3,3-dimethylureido)propyl, 2-(3-melhylureido)ethyl, 3-(3-methylureido)propyl, 2-ureidoethyl, 3-ureidopropyl, 2-(N,N- dimethylcarbamoyloxy)ethyl, 3-(N,N-dimethylcarbamoyloxy)propyl, 2-(N- methylcarbamoyloxy)ethyl, 3-(N-methylcarbamoyloxy)propyl, 2-(carbamoyloxy)ethyl, 3-(carbamoyloxy)propyl; 3) C 2-3 alkylX 9 R 26 (wherein X 9 is as defined in claim 1 and R 26 is a group selected from Cι -2 alkyl, cyclopentyl, cyclohexyl, pyrrolidinyl and piperidinyl which group is linked to X 9 through a carbon atom and which Cj. 2 alkyl group may bear one or two substituents selected from hydroxy, halogeno and Cι_ 2 alkoxy and which cyclopentyl, cyclohexyl, pyrrolidinyl or piperidinyl group may carry one substituent selected from oxo, hydroxy, halogeno, Cι_ 2 alkyl, Cι -2 hy droxy alkyl and Cι -2 alkoxy); 4) C 2-3 alkylX 10 C 2 . 3 alkylX u R 32 (wherein X 10 and X 11 are as defined in claim 1 and R 32 represents hydrogen or Cι -2 alkyl); 5) R 38 (wherein R 38 is as defined in claim 1); 6) (wherein is a group selected from pyrrolidinyl, piperazinyl, piperidinyl, 1 ,3-dioxolan-2-yl, l,3-dioxan-2-yl, 1 ,3-dithiolan-2-yl and 1 ,3-dithian-2-yl, which group is linked to Cι. 2 alkyl through a carbon atom and which group may carry one substituent selected from oxo, hydroxy, halogeno, Cι -2 alkyl, Cι -2 hy droxy alkyl and Cι -2 alkoxy) or C 2-3 alkylR 68 (wherein R 68 is a group selected from moφholino, thiomoφholino, piperidino, piperazin- 1-yl and pyrrolidin-1-yl which group may carry one or two substituents selected from oxo, hydroxy, halogeno, Cι -2 alkyl, d_ 2 hy droxy alkyl and Cj_ 2 alkoxy); 7) R 39 (wherein R 39 is as defined in claim 1); 8) Cι -4 alkylR 39 (wherein R 39 is as defined in claim 1); 9) l-R 39 but-2-en-4-yl (wherein R 39 is as defined in claim 1); 10) l-R 39 but-2-yn-4-yl (wherein R 39 is as defined in claim 1); 11) C 2- alkylX 12 R 39 (wherein X 12 and R 39 are as defined in claim 1); 12) l-(R 39 X 13 )but-2-en-4-yl (wherein X 13 and R 39 are as defined in claim 1); 13) l-(R 39 X 14 )but-2-yn-4-yl (wherein X 14 and R 39 are as defined in claim 1); 14) ethylX 15 methylR 39 (wherein X 15 and R 39 are as defined in claim 1); and 15) ethylX 15 methylR 38 (wherein X 15 and R 38 are as defined in claim 1)]. 7. A compound as claimed in claim 1 of the formula la: (la) [wherein: R 1 , R 2 , ring Z and n are as defined in claim 1; R ,3a represents hydrogen, hydroxy, methoxy, amino, nitro or halogeno; R ,4a represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, Cι -3 alkyl, d. 3 alkoxy, d. 3 alkylthio, -NR 6a R 7a - (wherein R 6a and R 7a , which may be the same or different, each represents hydrogen or Cι -3 alkyl), or a group R 8a (CH 2 ) ta X 2a (wherein R 8a is a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, Cι -4 alkyl, Cι -4 hy droxy alkyl and Cι -4 alkoxy, ta is an integer from 0 to 4 and X 2a represents a direct bond, -O-, -CH 2 -, -S-, -SO-, -SO 2 -, -NR 9a CO-, - CONR 10a -, -SO 2 NR l la -, -NR 12a SO 2 - or -NR 13a - (wherein R 9a , R 10a , R l la , R 12a and R 13a each independently represents hydrogen, X la represents a direct bond, -O-, -CH 2 -, -S-, -SO-, -SO 2 -, -NR 14a CO-, -CONR 153 -, - SO 2 NR 16a -, -NR 17a SO 2 - or -NR 18a - (wherein R 14a , R 15a , R 16a , R 17a and R 18a each independently represents hydrogen, Cι- 3 alkyl or Cι. 3 alkoxyC 2 .3alkyl); R 5a is selected from one of the following seventeen groups: 1) hydrogen or Ci-salkyl which may be unsubstituted or which may be substituted with one or more groups selected from hydroxy, fluoro and amino; 2) Cι.salkylX 3a COR 19a (wherein X 3a represents -O- or -NR 20a - (in which R 20a represents hydrogen, Cι -3 alkyl or d -3 alkoxyC 2- 3alkyl) and R 19a represents Cι. 3 alkyl, - NR 21a R 22a_ or _ QR 23a (wherein R 2 R 22a ^ R 23a which may be ±e SQmQ Qr different each represents hydrogen, Cι -3 alkyl or Cι. 3 alkoxyC 2 - 3 alkyl)); 3) Cι- 5 alkylX 4a R 24a (wherein X 4a represents -O-, -S-, -SO-, -SO 2 -, -OCO-, -NR 25a CO-, -CONR 26a -, -SO 2 NR 27a -, -NR 28a SO 2 - or -NR 29a - (wherein R 25a , R 26a , R 27a , R 28a and R 29a each independently represents hydrogen, Cι_ 3 alkyl or d -3 alkoxyC 2-3 alkyl) and R 24a represents hydrogen, Cι -3 alkyl, cyclopentyl, cyclohexyl or a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which group may bear one or two substituents selected from oxo, hydroxy, halogeno and Cj. 4 alkoxy and which cyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, Cι -4 alkyl, Cι_ 4 hydroxyalkyl and Cι -4 alkoxy); 4) Cι. 5 alkylX 5a C, -5 alkylX 6a R 30a (wherein X 5a and X 6a which may be the same or different are each -O-, -S-, -SO-, -SO 2 -, -NR 31a CO-, -CONR 32a -, -SO 2 NR 33a -, -NR 34a SO 2 - or - NR 35a - (wherein R 31a , R 32a , R 33 \ R 34a and R 35a each independently represents hydrogen, 5) R 36a (wherein R 36a is a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, Cι -4 alkyl, Cι_ 4 hy droxy alkyl and Cι -4 alkoxy); 6) C,. 5 alkylR 36a (wherein R 6a is as defined herein); 7) C 2 . 5 alkenylR 36a (wherein R 36a is as defined herein); 8) C 2 . 5 alkynylR 36a (wherein R 36a is as defined herein); 9) R 37a (wherein R 37a represents a pyridone group, a phenyl group or a 5 or 6-membered aromatic heterocyclic group with 1 to 3 heteroatoms selected from O, N and S, which pyridone, phenyl or heterocyclic group may carry up to 5 substituents selected from hydroxy, halogeno, amino, Cι -4 alkyl, Cι -4 alkoxy, Cι -4 hydroxyalkyl, Cι. 4 aminoalkyl, Cι -4 hydroxyalkoxy, carboxy, trifluoromethyl, cyano, -CONR 38a R 39a and - NR 40a COR 41a - (wherein R 38a , R 39a , R 40a and R 41a , which may be the same or different, each represents hydrogen, Cι- alkyl or Ci ^alkoxy C 2-3 alkyl)); 10) Cι -5 alkylR 37a (wherein R 37a is as defined herein); 11) C 2-5 alkenylR 37a (wherein R 37a is as defined herein); 12) C 2 . 5 alkynylR 37a (wherein R 37a is as defined herein); 13) C, -5 alkylX 7a R 37a (wherein X 7a represents -O-, -S-, -SO-, -SO 2 -, -NR 2a CO-, - CONR 43a -, -SO 2 NR 443 -, -NR 45a SO 2 - or -NR 46a - (wherein R 42a , R 43a , R 44a , R 45a and R 46a each independently represents hydrogen, Ci^alkyl or Cι. 3 alkoxyC -3 alkyl) and R 37a is as defined herein); 14) C 2 . 5 alkenylX 8a R 37a (wherein X 8a represents -O-, -S-, -SO-, -SO 2 -, -NR 47a CO-, - CONR 48a -, -SO 2 NR 49 \ -NR 50a SO 2 - or -NR 51a - (wherein R 47a , R 48a , R 49a , R 50a and R 51a each independently represents hydrogen, or Cι. 3 alkoxyC 2 - 3 alkyl) and R 37a is as defined herein); 15) C 2 . 5 alkynylX 9a R 37a (wherein X 9a represents -O-, -S-, -SO-, -SO 2 -, -NR 52a CO-, - CONR 53 \ -SO 2 NR 54a -, -NR 55a SO 2 - or -NR 56a - (wherein R 52a , R 53a , R 54a , R 55a and R 56a each independently represents hydrogen, Cι -3 alkyl or Cι -3 alkoxyC 2-3 alkyl) and R 37a is as defined herein); 16) Cι -3 alkylX 10a C, -3 alkylR 37a (wherein X 10a represents -O-, -S-, -SO-, -SO 2 -, - NR 57a CO-, -CONR 58a -, -SO 2 NR 59a -, -NR 60a SO 2 - or -NR 61a - (wherein R 57a , R 58a , R 59a , R 60a and R 61a each independently represents hydrogen, Cι_ 3 alkyl or d. 3 alkoxyC 2-3 alkyl) and R 37a is as defined herein); and 17) C, -3 alkylX 10a C,. 3 alkylR 36a (wherein X 10a and R 36a are as defined herein)]. 8. A compound as claimed in claim 7 wherein ring Z is a 6-membered heterocyclic ring containing 1 to 3 nitrogen atoms with the proviso that the group at the 4-position of the quinazoline ring is not a substituted or unsubstituted group selected from 4,5,7-triazaoxindol- 3-yl and 4,6,7-triazaoxindol-3-yl. 9. A compound as claimed in claim 7 wherein ring Z is a 6-membered heterocyclic ring containing 1 or 2 nitrogen atoms with the proviso that where R 2 is a group R 4 X', X 1 is not C 2- alkanoyl or -SO 2 R 10 - and R 4 is not optionally substituted phenyl or an optionally substituted 5or 6-membered unsaturated heterocyclic ring. 10. A compound as claimed in any one of claims 7 to 9 wherein R 1 is hydrogen. 11. A compound as claimed in any one of claims 7 to 10 wherein R 2 is halogeno, Cι -2 alkyl, Cι -2 alkoxy, trifluoromethyl, 2,2,2-trifluoroethyl, cyano, nitro, Cι -3 alkanoylamino, Cι -3 alkylsulphonyl, carbamoyl, N-Cι -3 alkylcarbamoyl, N,N-di(Cι. 3 alkyl)carbamoyl, aminosulphonyl, N-Cι -3 alkylaminosulphonyl, N,N-di(Cι_ 3 alkyl)aminosulphonyl or Cι- 3 alkylsulphonylamino or R 2 is selected from one of the following four groups: 1) R X l wherein X 1 represents -O-, -NR 5 -, d -3 alkyl, -CONR 6 R 7 - or -SO 2 NR 8 R 9 - (wherein R 5 , R 6 , and R 8 , each independently represents hydrogen or Cj. 2 alkyl and R 7 and R 9 each independently represents Cι -3 alkyl and wherein R 4 is linked to R 7 or R 9 ) and R 4 represents a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group may bear two oxo substituents on a ring sulphur heteroatom; 2) X 2 C 2 . 3 alkylX 3 methyl (wherein X 2 is -O- or -NR 1 ' - (wherein R 1 ' is hydrogen or d -2 alkyl) and X 3 is -O-, -NR 12 - or -SO 2 - (wherein R 12 is hydrogen or Cι. 2 alkyl); 3) Cι -2 alkylX 4 C 2-3 alkylX 5 methyl (wherein X 4 and X 5 which may be the same or different are each -NR 13 - or -SO 2 - (wherein R 13 is hydrogen or Cι -2 alkyl); and 4) Cι -2 alkylX 6 C, -2 alkyl (wherein X 6 is -O-, -NR 14 - or -SO 2 - (wherein R 14 is hydrogen or C 1-2 alkyl). 12. A compound as claimed in any one of claims 7 to 11 wherein R a is hydrogen. 13. A compound as claimed in any one of claims 7 to 12 wherein R 4a is hydrogen, hydroxy, cyano, nitro, trifluoromethyl, methyl, ethyl, methoxy, ethoxy or a group R 8a (CH 2 ) ta X 2a (wherein R 8a is a group selected from pyrrolidinyl, piperazinyl, piperidinyl, moφholino and thiomoφholino which group may carry one or two substituents selected from oxo, hydroxy, halogeno, d -2 alkyl, d -2 hy droxy alkyl and Cι -2 alkoxy, X 2a is -O-, -S-, --N vNrRrR 1 1' 2 2 a a a SS, OO 22 -- ((wwhheerreeiinn RR 9yaa aanndd RR 1,2aa eeaacchh independently represents hydrogen or Cι- 2 alkyl) or NH and ta is an integer from 1 to 3). 14. A compound as claimed in any one of claims 7 to 13 wherein X la is -O-, -S-, - NR 14a CO-, -NR 17a SO 2 - (wherein R 14a and R 17a each independently represents hydrogen or C|. 2 alkyl) or NH. 15. A compound as claimed in any one of claims 7 to 14 wherein R 5a is selected from one of the following fifteen groups: 1) Cι. 3 alkyl which may be unsubstituted or substituted with one or more fluorine atoms, or C 2 . 3 alkyl which may be unsubstituted or substituted with one or two groups selected from hydroxy and amino; 2) 2-(3,3-dimethylureido)ethyl, 3-(3,3-dimethylureido)propyl, 2-(3-methylureido)ethyl, 3-(3-methylureido)propyl, 2-ureidoethyl, 3-ureidopropyl, 2-(N,N- dimethylcarbamoyloxy)ethyl, 3-(N,N-dimethylcarbamoyloxy)propyl, 2-(N- methylcarbamoyloxy)ethyl, 3-(N-methylcarbamoyloxy)propyl, 2-(carbamoyloxy)ethyl, 3-(carbamoyloxy)propyl; 3) C 2-3 alkylX 4a R 24a (wherein X 4a is as defined in claim 7 and R 24a is a group selected from Cι -2 alkyl, cyclopentyl, cyclohexyl, pyrrolidinyl and piperidinyl which group is linked to X 4a through a carbon atom and which Cι -2 alkyl group may bear one or two substituents selected from hydroxy, halogeno and Cι -2 alkoxy and which cyclopentyl, cyclohexyl, pyrrolidinyl or piperidinyl group may carry one substituent selected from oxo, hydroxy, halogeno, C )-2 alkyl, Cι -2 hy droxy alkyl and Cι -2 alkoxy); 4) C 2-3 alkylX 5a C 2 _ 3 alkylX 6a R 30a (wherein X 5a and X 6a are as defined in claim 7 and R 30a represents hydrogen or Cι_ 2 alkyl); 5) R 36a (wherein R 36a is as defined in claim 7); 6) Cι -2 alkylR 65a (wherein R 65a is a group selected from pyrrolidinyl, piperazinyl, piperidinyl, l,3-dioxolan-2-yl, l,3-dioxan-2-yl, 1 ,3-dithiolan-2-yl and l,3-dithian-2-yl, which group is linked to Cι_ 2 alkyl through a carbon atom and which group may carry one substituent selected from oxo, hydroxy, halogeno, Cι -2 alkyl, Cι_ 2 hy droxy alkyl and Cι_ 2 alkoxy) or C 2-3 alkylR 66a (wherein R 66a is a group selected from moφholino, thiomorpholino, piperidino, piperazin- 1-yl and pyrrolidin-1-yl which group may carry one or two substituents selected from oxo, hydroxy, halogeno, C !-2 alkyl, Cι -2 hydroxyalkyl and Cι -2 alkoxy); 7) R 37a (wherein R 37a is as defined in claim 7); 8) Cι. 4 alkylR 37a (wherein R 37a is as defined in claim 7); 9) l-R 37a but-2-en-4-yl (wherein R 37a is as defined in claim 7); 10) l-R 37a but-2-yn-4-yl (wherein R 37a is as defined in claim 7); 11) C 2-4 alkylX 7a R 37a (wherein X 7a and R 37a are as defined in claim 7); 12) l-(R 37a X 8a )but-2-en-4-yl (wherein X 8a and R 37a are as defined in claim 7); 13) l-(R 37a X 9a )but-2-yn-4-yl (wherein X 9a and R 37a are as defined in claim 7); 14) ethylX 10a methylR 37a (wherein X 10a and R 37a are as defined in claim 7); and 15) ethylX rl ι O υ a a methylR ,3 J 6 o a a (wherein X 1 ι 0 υ a a and R >3 J 6 o a a are as defined in claim 7) 16. A compound as claimed in claim 1 of the formula lb: (lb) [wherein: R lb represents hydrogen; R 2b represents halogeno, Cι -2 alkyl, d -2 alkoxy, trifluoromethyl, 2,2,2-trifluoroethyl, cyano, nitro, carbamoyl, N-Cι -3 alkylcarbamoyl, N,N- di(Cι. 3 alkyl)carbamoyl, aminosulphonyl, N-Cι -3 alkylaminosulphonyl, N,N-di(Cι -3 alkyl)- aminosulphonyl or Cι- 3 alkylsulphonylamino or R 2b is selected from one of the following four groups: 1) R 6b X 2b wherein X 2b represents -O-, -NR 7b -, C 1-3 alkyl, -CONR 8b R 9b - or - SO 2 NR 10b R l lb - (wherein R 7b , R 8b , and R 10b , each independently represents hydrogen or Cι -2 alkyl and R 9b and R l lb each independently represents Cι -3 alkyl and wherein R 6b is linked to R 9b or R l lb ) and R 6b represents a 5 or 6-membered saturated heterocyclic group with one or two heteroatoms, selected independently from O, S and N, which heterocyclic group may bear two oxo substituents on a ring sulphur heteroatom; 2) X 3b C 2-3 alkylX 4b methyl (wherein X 3b is -O- or -NR 1 b - (wherein R l b is hydrogen or Cι -2 alkyl) and X 4b is -O-, -NR 13b - or -SO 2 - (wherein R 13b is hydrogen or Cι. 2 alkyl); 3) a —nd J v X6 0 b D which may be the same or different are each -NR R 1144bb -- oorr --SSOO 22 -- ((wwhheerreeiinn RR 1144bb iiss hhyyddrrooggeenn oorr CCιι --22 aallkkyyll));; aanndd 4) C,. 2 alkylX 7b D C--,ι -2 a „nlk„y.ιl / (.w..ιherei :„n v X7'b D i • s xτr -NR> 1 1 5 3 b - o „_r -S C O-Λ 2 - ( /„w.Iherei :„n r R1 O 5b D is hydrogen or Cι_ 2 alkyl); nb is an integer from 0 to 2; ring Zb is a 6-membered aromatic heterocyclic ring containing 1 or 2 nitrogen atoms such that the substituent at the 4-position of the quinazoline ring is selected from the groups 7-azaoxindol-3-yl and 5,7-diazaoxindol-3-yl which group bears (R 2b ) nb as defined herein; R 2b is attached at the 5- and/or 6-positions of the heteroaromatic oxindole ring, but if R 2b is fluoro it can be attached at the 4-, 5-, 6- or 7-position(s) of the heteroaromatic oxindole ring; R 3b represents hydrogen; R 4b represents represents hydrogen, hydroxy, cyano, nitro, trifluoromethyl, methyl, methoxy or a group R 16b (CH 2 ) t ι,X 8b (wherein R 16b represents a group selected from pyrrolidinyl, piperazinyl, piperidinyl, moφholino and thiomoφholino which group may carry one or two substituents selected from oxo, hydroxy, halogeno, Cj_ 2 alkyl, Cι_ 2 hy droxy alkyl and Cι -2 alkoxy, tb is an integer from 1 to 3 and X 8b represents -O-, -S-, -NR 17b CO-, -NR 18b SO 2 - (wherein R 17b and R 18b each independently represents hydrogen or Cι_ 2 alkyl) or NH); X lb represents -O- or -NR 19b CO- (wherein R 19b represents hydrogen or Cj. 2 alkyl); and R 5b represents methyl, ethyl, trifluoromethyl, 2,2,2-trifluoroethyl, 2-hydroxyethyl, 3- hy droxy propyl, 2-(N,N-dimethylsulphamoyl)ethyl, 2-(N-methylsulphamoyl)ethyl, (1,3- dioxolan-2-yl)methyl, 2-(l,3-dioxolan-2-yl)ethyl, 2-(2-methoxyethylamino)ethyl, 2-(2- hy droxy ethylamino)ethyl, 3-(2-methoxyethylamino)propyl, 3-(2-hydroxyethylamino)propyl, 2-( 1 ,2,4-triazol- 1 -yl)ethyl, 2-( 1 ,2,4-triazol-4-yl)ethyl, 3-( 1 ,2,4-triazol- 1 -yl)propyl, 3-( 1 ,2,4- triazol-4-yl)propyl, 2-(4-pyridyloxy)ethyl, 3-(4-pyridyloxy)propyl, 2-(4-pyridylamino)ethyl, 3- (4-pyridylamino)propyl, 2-(2-methylimidazol-l-yl)ethyl, 3-(2-methylimidazol-l-yl)propyl, 2- (5-methyl-l,2,4-triazol-l-yl)ethyl, 3-(5-methyl-l,2,4-triazol-l-yl)propyl, moφholino, N- methylpiperazinyl, piperazinyl, 2-(N,N-dimethylamino)ethyl, 3-(N,N-dimethylamino)propyl, 2-moφholinoethyl, 3-moφholinopropyl, 2-piperidinoethyl, 3-piperidinopropyl, 2-(piperazin- 1 -yl)ethyl, 3-(piperazin- 1 -yl)propyl, 2-(pyrrolidin- 1 -yl)ethyl, 3-(pyrrolidin- 1 -yl)propyl, 2- methoxyethyl, 3-methoxypropyl, 2-(imidazol-l-yl)ethyl, 2-(l,2,3-triazol-l-yl)ethyl, 2-( 1,2,3- triazol-2-yl)ethyl, 3-(imidazol-l-yl)ρropyl, 3-(l,2,3-triazol-l-yl)propyl, 3-(l,2,3-triazol-2- yl)propyl, 2-thiomoφholinoethyl, 3-thiomoφholinopropyl, 2-(l,l-dioxothiomoφholino)ethyl, 3-( 1 , 1 -dioxothiomoφholino)propyl, 2-(2-methoxyethoxy)ethyl, 2-(4-methylpiperazin- 1 - yl)ethyl, 3-(4-methylpiperazin-l-yl)propyl, 3-(methylsulphinyl)propyl, 3- (methylsulphonyl)propyl, 2-(methylsulphinyl)ethyl or 2-(methylsulphonyl)ethyl]. 17. A compound as claimed in claim 1 selected from: 4-(7-azaoxindol-3-yl)-6-methoxy-7-(3-moφholinopropoxy)quinazoline, 4-(7-azaoxindol-3-yl)-7-(2-(imidazol-l-yl)ethoxy)-6-methoxyquinazoline, 4-(5,7-diaza-6-methyloxindol-3-yl)-7-(3-moφholinopropoxy)quinazoline and 4-(4-aza-6-trifluoromethyloxindol-3-yl) 6-methoxy-7-(3-moφholinopropoxy)quinazoline and salts thereof. 18. A compound as claimed in claim 1 selected from: 4-(5,7-diaza-6-methyloxindol-3-yl)-7-(3-(l,l-dioxothiomoφholino)propoxy)quinazoline, 4-(7-aza-6-chlorooxindol-3-yl)-7-(3-moφholinopropoxy)quinazoline, 4-(7-azaoxindol-3-yl)-7-(4-moφholinobut-2-en- 1 -yloxy)quinazoline and 4-(5,7-diaza-6-methyloxindol-3-yl)-7-(3-methylsulphonylpropoxy)quinazoline and salts thereof. 19. A compound as claimed in claim 1 selected from: 4-(5,7-diaza-6-methyloxindol-3-yl)-7-(3-moφholinopropoxy)quinazoline, 4-(7-azaoxindol-3-yl)-7-(2-(2-methoxyethoxy)ethoxy)quinazoline and 4-(7-azaoxindol-3-yl)-7-(3-moφholinopropoxy)quinazoline and salts thereof. 20. A compound as claimed in any one of the preceding claims in the form of a pharmaceutically acceptable salt. 21. A process for the preparation of a compound of formula I or salt thereof (as defined in claim 1) which comprises: (a) the reaction of a compound of the formula III: (m) (wherein R and m are as defined in claim 1 and L is a displaceable moiety), with a compound of the formula IV: (IV) (wherein R 1 , R 2 ring Z and n are as defined in claim 1) whereby to obtain compounds of the formula I and salts thereof; (b) the deprotection of a compound of formula V: (V) (wherein R >2 , R , n, ring Z and m are as defined in claim 1 and P represents a protecting group); (c) the reduction and cyclisation of a compound of formula VI: (VI) (wherein R 2 , R 3 , m, ring Z and n are as defined in claim 1 and Y represents cyano, carboxy or Cι -4 alkoxy carbonyl); (d) for the preparation of those compounds of formula I and salts thereof wherein at least one of the R 2 groups is hydroxy, the deprotection of a compound of formula VII: (VH) (wherein R 1 , R 2 , R 3 , n, ring Z and m are as defined in claim 1, P represents a phenolic hydroxy protecting group and pi is an integer from 1 to 3 equal to the number of protected hydroxy groups and such that n-pl is equal to the number of R substituents which are not protected hydroxy); (e) for the preparation of those compounds of formula I and salts thereof wherein at least one R 3 is R I5 X 7 wherein R 15 is as defined in claim 1 and X 7 is -O-, -S-, -SO 2 -, - CONR 17 -, -SO 2 NR 18 - or -NR 20 - (wherein R 17 , R 18 and R 20 each independently represents hydrogen, the reaction of a compound of the formula VIII: (VIA) (wherein R 1 , R 2 , R 3 , n, ring Z and X 7 are as defined in claim 1 and s is an integer from 0 to 3) with a compound of formula IX: R 15 -L' (IX) (wherein R 15 is as defined in claim 1 and L 1 is as defined herein); (f) for the preparation of those compounds of formula I and salts thereof wherein at least one R 3 is R 15 X 7 wherein R 15 is as defined in claim 1 and X 7 is -O-, -S-, or -NR 20 - (wherein R 20 represents hydrogen, Cι -3 alkyl or Cι -3 alkoxyC2 -3 alkyl), the reaction of a compound of the formula X: (X) with a compound of the formula XI: R I5 -X 7 -H (Xi) (wherein L 1 and s are as defined herein and R l , R 2 , R 3 , R 15 , n, ring Z and X 7 are all as defined in claim 1); (g) for the preparation of compounds of formula I and salts thereof wherein at least one R 3 is R 15 X 7 wherein X 7 is as defined in claim 1 and R 15 is Cι -5 alkylR 70 , [wherein R 70 is selected from one of the following six groups: 1) X 16 C, -3 alkyl (wherein X 16 represents -O-, -S-, -SO 2 -, -NR 71 CO- or -NR 72 SO 2 - (wherein R 71 and R 72 which may be the same or different are each hydrogen, Cι -3 alkyl or Cι -3 alkoxyC 2-3 alkyl); 2) NR R (wherein R and R which may be the same or different are each hydrogen, d -3 alkyl or Cι -3 alkoxyC 2 . 3 alkyl); 3) X 17 Cι. 5 alkylX H R 32 (wherein X 17 represents -O-, -S-, -SO 2 -, -NR 75 CO-, -NR 76 SO 2 - or -NR 77 - (wherein R 75 , R 76 , and R 77 which may be the same or different are each hydrogen, Cι- 3 alkyl or Cι- 3 alkoxyC 2 . 3 alkyl) and X 11 and R 32 are as defined in claim 1); 4) R 65 (wherein R 65 is a 5 or 6-membered saturated heterocyclic group witii one or two heteroatoms of which one is N and the other is selected independently from O, S and N, which heterocyclic group is linked to C 2 .salkyl through a nitrogen atom and which heterocyclic group may bear one or two substituents selected from oxo, hydroxy, halogeno, d. 4 alkyl, and Cι. 4 alkoxy); 5) X '1 1 8 8 R D 3 j 9 y (wherein X rl'8° represents -O-, -S-, -SO 2 -, -NR 7'8 δ ,CO-, -NR >7 , 9 y Sj O 2 -, or -NR ,80 (wherein R 78 , R 79 , and R 80 which may be the same or different are each hydrogen, Cι. 3 alkyl or Cι. 3 alkoxyC 2 . 3 alkyl) and R 39 is as defined in claim 1); and 6) X 19 Cι -5 alkylR 39 (wherein X 19 represents -O-, -S-, -SO 2 -, -NR 81 CO-, -NR 82 SO 2 - or - NR 83 - (wherein R 81 , R 82 and R 83 each independently represents hydrogen, or Cι- 3 alkoxyC 2 . 3 alkyl) and R 39 is as defined in claim 1);] reacting a compound of the formula XII: (Xii) (wherein L 1 and s are as defined herein and X 7 , R 1 , R 2 , R 3 , n and ring Z are as defined in claim 1) with a compound of the formula XIII: R 70 -H (XIII) (wherein R >70 i •s as defined herein) to give a compound of the formula I or salt thereof; (h) for the preparation of those compounds of formula I and salts thereof wherein one or more of the substituents (R 3 ) m is represented by -NR 84 R 85 -, where one or both of R 84 and R 85 are Cι. 3 alkyl, d e reaction of compounds of formula I wherein the substituent (R 3 ) m is an amino group and an alkylating agent; for the preparation of tiiose compounds of formula I and salts thereof wherein one or more of die substituents R 2 or R 3 is an amino group the reduction of a corresponding compound of formula I wherein the substituent(s) at the corresponding position(s) of the quinazoline and/or heteroaromatic oxindole group is/are a nitro group(s); and when a salt of a compound of formula I is required, reaction of the compound obtained with an acid or base whereby to obtain the desired salt. 22. A pharmaceutical composition which comprises as active ingredient a compound of formula I as defined in claim 1 or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable excipient or carrier. 23. A method for producing an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal in need of such treatment which comprises administering to said animal an effective amount of a compound of formula I as defined in claim 1 or a pharmaceutically acceptable salt thereof. 24. A compound as claimed in any one of claims 1 to 19 or a pharmaceutically acceptable salt thereof for use as a medicament.

Inventors: HENNEQUIN LAURENT FRANCOIS AND, LOHMANN JEAN-JACQUES MARCEL, PLE PATRICK, THOMAS ANDREW PETER, HENNEQUIN, LAURENT, FRANCOIS, ANDRE, LOHMANN, JEAN-JACQUES, MARCEL, PLE, PATRICK, THOMAS, ANDREW, PETER
Applicants: HENNEQUIN LAURENT FRANCOIS AND, LOHMANN JEAN JACQUES MARCEL, PLE PATRICK, THOMAS ANDREW PETER, ZENECA LTD, ZENECA PHARMA SA, HENNEQUIN, LAURENT, FRANCOIS, ANDRE, LOHMANN, JEAN-JACQUES, MARCEL, PLE, PATRICK, THOMAS, ANDREW, PETER, ZENECA LIMITED, ZENECA-PHARMA S.A.
Application year: 1998
Main classification: C07D487
IPC codes: A61K31, C07D471, C07D487