Process for the preparation of chloro-benzoyl chlorides

Abstract: An effective and efficient process for the preparation of chloro-benzoylchlorides of formula I, (n is defined in the specification) is described. In this process a chloro-trichloromethylbenzene of formula II is treated with water in the presence of a Lewis at temperatures below 80 °C. The compounds obtained according to this process can be used to prepare certain chloro-substituted benzophenones useful as fungicides.

Description: The present invention relates to a process for the preparation of chloro-benzoylchlorides from a chloro-trichloromethylbenzene. Chloro-trichloromethylbenzene compounds are suitable intermediates for the preparation of a broad variety of compounds which are useful as agrochemicals, pharmaceuticals or liquid crystals. In particular, they are key intermediates in the preparation of fungicidal dimethomorph (e.g. EP 0 120 321) and fungicidal benzophenones which are described for example in EP 0 727 141 A. The German patent no. 331696 (July 17, 1914) discloses a process wherein trichloromethylbenzene is treated with equimolar amounts of water in the presence of FeCl 3 at elevated temperatures to form benzoylchloride. However, this process is difficult to carry out on a technical scale in view of problems with respect to the dosing rate and the exact equimolar dosing of water at elevated temperatures. Any excess of water will cause hydrolysis of the desired acid chloride compound and therefore reduce the yields. The present invention provides an effective and efficient process for the preparation of chloro-benzoylchlorides of formula I, wherein n represents an integer 1, 2 or 3, from a chloro-trichloromethylbenzene of formula II wherein n is as defined above, characterised in that the trichloromethylarene is treated with water in the presence of a Lewis acid at temperatures below 80 °C. It is, therefore, an object of the present invention to provide an efficient new process for the preparation of chloro-benzoylchloride compounds. Other objects and advantages of the present invention will be apparent to those skilled in the art from the following description and the appended claims. Further preferred embodiments of the process according to the present invention is a process wherein: the reaction is carried out without organic solvent; the Lewis acid is FeCl 3 , the reaction mixture essentially consisting of the chloro-trichloromethylbenzene of formula II and the Lewis acid is heated up to temperatures below 80 °C and water is slowly added into the stirred solution; the chloro-trichloromethylbenzene is a mono- or dichlorotrichloromethylbenzene, in particular 4-chloro-trichloromethylbenzene or 2,6-dichlorotrichloromethylbenzene; I mole of trichloromethylarene of formula II is treated with 0.8 to 1.2, preferably 0.9 to 1.1, in particular about 1 moles of water; 1 mole of trichloromethylarene of formula II is treated with water in the presence of 0.05 to 5 mol-%, preferably 0.1 to 3 mol-% of the Lewis acid. The reaction is carried out at a temperature between ambient temperature and 80 °C, preferably between 40 and 80 °C, in particular between 45 and 65 °C. As a rule the reaction can be carried out under reduced or elevated pressure, preferably it is carried out under ambient pressure. In a particularly preferred embodiment of the process according to the invention 1 equivalent of 4-chloro-trichloromethylbenzene, is mixed with 0.1 to 3 mol-% of the Lewis acid, in particular FeCl 3 and heated to 45 to 65°C, in particular 50 to 60 °C. Then about 1 equivalent of water is slowly dosed (eg over a period of 1 to 2 hours or more) into the stirred reaction mixture, which is kept at this temperature. The water may be introduced via one or more inlets, preferably via one or two inlets at a dosing rate of 0.1 to 0.8 ml/min, preferably 0.2 to 0.5 ml/min. In another preferred embodiment the water is dosed as steam instead as liquid. As a rule, water is lead in a defined rate through a pipe which is heated to 140 °C using an inert atmosphere, preferably nitrogen or argon as steam carrier. The steam preferably is introduced into the reaction mixture in the form of a fine dispersion of the reagents. In order to prevent the formation of benzoic anhydrides as a by-product the steam is introduced using less than 50 %, preferably about 25 % nitrogen as carrier. Preferably the mixing of the steam with the reaction mixture is enhanced by one or more baffles. The hydrochloric acid formed during the reaction is evolved out until the reaction is completed. Under these preferred reaction conditions the reaction is as a rule completed within 0.25 to 8, in particular 4 to 6 hours. It has been found that the reaction time depends on the stirring rate of the reaction mixture. Optimal reaction conditions were found with a stirring power input of 0.5 to 2.0 kW/m3, in particular of about 1.0 kW/m3. The dependence of the stirring power input and the volume of the reaction mixture, the stirrer geometry and the stirring rate is given by the following formula: P = P 0 * ρ * n 3 * d/V P = power input P 0 = standard value for a certain stirrer ρ = density n = stirring speed d = diameter of the stirrer V = volume The remaining benzoylchloride can be used as intermediate for the preparation of the desired end-products without further purification. In a particularly preferred embodiment the reaction mixture obtained can be used for the preparation of certain chloro-substituted benzophenone derivatives under Friedel-Crafts acylation conditions, in particular of formula III, in which n has the meaning given, R each independently represents C 1-6 alkyl or C 1-6 alkoxy, and m is an integer from 2 to 4, under Friedel-Crafts acylation conditions by adding the corresponding substituted benzene derivative, preferably of formula IV, in particular 1,2-dimethoxybenzene, 3,4,5-trimethoxytoluene or 3,4-dimethoxy-5-butoxytoluene, and optionally adding a Lewis acid to said reaction mixture, preferably without adding additional Lewis acid. It is also possible to purify the obtained chloro-benzoylchlorides using standard procedures, as for example crystallization or distillation, in particular by distillation under reduced pressure, in particular at pressures between I and 100 mbar. The novel process enables to carry out the production of chloro-benzoyl chlorides in technical scale and high yields using cheap, readily-available materials. In order to facilitate a further understanding of the invention, the following illustrative examples are presented. The invention is not limited to the specific embodiments described or illustrated, but encompasses the full scope of the appended claims. Example 1 Preparation of 4-chlorobenzoylchloride (PCBO) A mixture of 115 g 4-chlorobenzotrichloride (CBTC, 0.5 mol) and 1.6 g FeCl 3 (10 mmol) is heated to 60°C. 9 g water (0.5 mol) are dosed into the mixture within 1 hours at ambient pressure. After 30 minutes the reaction was complete; the GC analysis showed that the conversion was complete (98 area-% PCBO). In order to determine the yield, the corresponding methyl-ester has been made by adding 1,5 equivalent methanol to the obtained product. The resulting mixture was disolved in toluene and washed with 5% aqueous HCl and water. After removing the solvent and recrystallization 83,3 g p-chloromethylbenzoate (98% purity) was formed. Total yield 93%. Example 2 Preparation of 4-chlorobenzoylchloride (PCBO) A mixture of 460 g 4-chlorobenzotrichloride (CBTC, 2 mol) and 6.5 g FeCl 3 (20 mmol) is heated to 50°C. 36 g water (2 mole) are dosed into the mixture within 2 hours at ambient pressure. After 30 minutes the reaction was complete; the GC analysis showed that the conversion was complete ( >95 area-% PCBO). The results of further experiments are given in the following table, in which the conversions have been determined by GC analysis: GC-area% PCBO of mixture CBTC (mol) FeCl 3 (mol %) T (°C) GC-area % PCBO 1,5 2 53 97 2 2 51 97 2 2 60 98 In the following experiments the yield of PCBO has been determined as the actual content of the product given in weight % as shown in Table 2: Weight% PCBO of mixture CBTC (mol) FeCl 3 (mol %) Stirrer (rpm) Dosing time (h) T (°C) weight % PCBO 2 0.5 420 4 50 94.2 2 0.25 420 4 50 95.3 3.25 0.4 388 6 50 95.5 3.25 0.25 388 4 70 88.6 3.25 0.25 388 4 50 96.3 Example 3 Preparation of 4-chlorobenzoylchloride (PCBO) A mixture of 3736 g 4-chlorobenzotrichloride (CBTC, 16.25 mol) and 6,6 g FeCl 3 (41 mmol) is heated to 50°C. 292 g water (16.25 mol) as steam mixed with 25 % nitrogen as carrier dosed are into the mixture within 8 hours at ambient pressure. After 30 minutes post-reaction time the reaction was complete; the GC analysis showed that the conversion was complete (97.4 area-% PCBO). Use Example Preparation of 4-chloro-3',4'-dimethoxybenzophenone (CDMBP) 552 g 1,2-dimethoxybenzene (4.0 mol) are added to a reaction mixture containing 703 g 4-chlorobenzoylchloride (PCBO, 4.0 mol) and FeCl 3 (1 mmol) as obtained from example 3. The reaction mixture is heated to 135 °C for 30 minutes. After usual work-up 1030 g of CDMBP (93 %) are isolated as pure product, melting point 109-111 °C. Comparison Example Preparation of 4-chloro-benzoylchloride A mixture of 460 g 4-chlorobenzotrichloride (CBTC, 2 mol) and 1.0 g FeCl 3 («20/6,5 » mmol) is heated to 100°C. 36 g water (2 mol) are dosed into the mixture within 2 hours at ambient pressure. After 30 minutes the analysis showed that the conversion was incomplete (85 weight % PCBO).

Claims: A process for the preparation of a chloro-benzoylchloride of formula I, wherein n represents an integer 1, 2 or 3, from a chloro-trichloromethylbenzene of formula II wherein n is as defined above, characterised in that the trichloromethylarene is treated with water in the presence of a Lewis acid at temperatures at or below 80 °C. A process according to claim 1, wherein 1 mole of chloro-trichloromethylbenzene of formula II is treated with 0.8 to 1.2 moles of water. A process according to claim 1 or claim 2, wherein 1 mole of trichloromethylarene of formula II is treated with water in the presence of 0.05 to 5.0 mol-% of the Lewis acid. A process as claimed in any one of claims 1 to 3 when carried out at a temperature of 40 to 80°C. A process as claimed in any one of claims 1 to 3 when carried out at a temperature from 45 to 65°C. A process according to any of the preceding claims, wherein about 1 equivalent of water is slowly dosed into a mixture essentially consisting of 1 equivalent of chloro-trichloromethylbenzene of formula II and 0.05 to 3.0 mol-% of the Lewis acid at 40 to 80°C. A process according to any of the preceding claims, wherein the water is introduced via one or more inlets at a dosing rate of 0.1 to 0.8 ml/min. A process according to any of the preceding claims, wherein the water is dosed as steam using an inert-gas as steam carrier. A process according to any of the preceding claims, wherein the reaction mixture is stirred during the introduction of water with a stirring power input of 0.5 to 2.0 kW/m3. A process according to any one of the preceding claims, wherein the Lewis acid is FeCl 3 . A process according to any one of the preceding claims in which the chloro-benzoylchlorides of formula I prepared is further reacted under Friedel-Crafts acylation conditions with a substituted benzene derivative of formula IV, wherein each R independently represents C 1-6 alkyl or C 1-6 alkoxy, and m is an integer from 2 to 4, and optionally a Lewis acid to give a chloro-substituted benzophenone derivative of formula III, in which n is an integer 1, 2 or 3, and R and m are as defined above. A process according t o any one of the preceding claims in which the reaction mixture containing the chloro-benzoylchlorides of formula I is further reacted under Friedel-Crafts acylation conditions with a substituted benzene derivative of formula IV, wherein each R independently represents C 1-6 alkyl or C 1-6 alkoxy, and m is an integer from 2 to 4, and optionally a Lewis acid to give a chloro-substituted benzophenone derivative of formula III, in which n is an integer 1, 2 or 3, and R and m are as defined above.

Inventors: BRINK MONIKA, VAN DEN AKKER LAURENS WILHEM, BRINK, MONIKA, VAN DEN AKKER, LAURENS WILHEM
Applicants: BASF AG, BASF AKTIENGESELLSCHAFT
Application year: 1998
Main classification: C07C51
IPC codes: C07C51, B01J27, C07C49, C07C63, C07B61, C07C45