USE OF DEHYDROEPIANDROSTERONE FOR THE TREATMENT OF ADDICTIONS

Abstract: This life saving invention relates to a simple, painless and easy method to stop smoking in a very easy way, almost unnoticed and also to a comfortable treatment of addictions and detoxication with the help of sex steroid precursors, like dehydroepiandrosterone (DHEA) or dehydroepiandrosteronesulfate (DHEAS) or an analogue thereof like (n)-alphafluoro- or bromo-epiandrosterone and also compounds destinated to be converted in vivo to either of the foregoing precursors. These precursors can with positive result, according to this invention, be brought into the blood for treatment of an addiction, like for instance as mentioned: the addiction to nicotine. The invention relates as well to the use of dehydroepiandrosterone or dehydroepiandrosteronesulfate or an analogue thereof like (n)-alphafluoro- or bromo-epiandrosterone and also compounds destinated to be converted in vivo to either of the foregoing precursors, for obtaining c.q. manufacturing a medicine, mentioned to bring in any way whatsoever, into the blood of a user of addictive substances, for therapeutical treatment of an addiction, like for instance: the addiction to nicotine, referring to the method and product as: "Wise Man's Brand" or WMB <c'>97.

Description: USE OF DEHYDROEPIANDROSTERONE FOR THE TREATMENT OF ADDICTIONS The present invention is concerned with a method for the treatment of addicted human beings and the use of specific steroids for that purpose. Particularly the invention relates to the treatment of nicoune-addicted people and the use of sex-steroid precursors for that purpose Smoking of tobacco may cause cancer and vascular deseases Particularly consumption of nicotine may cause arteriosclerosis, heartattacks. cerebral strokes, etc etc. So far no single effective method has been developed for the treatment of nicotine addicted humans and no effective pharmaceuticals have been disclosed usable for the treatment of humans, addicted to nicotine or other addicting products Recent nicotine containing anti-smoke treatments do increase nicotine levels and the above dangers for users who. regardless the prescription, continue smoking during treatment, adding nicotine on nicotine According to the present invention addicted humans can be cured by administering, bringing into the bloodstream in any way whatsoever of an effective amount of sex steroid precursors or an analogue thereof The invention also relates to the use of sex steroid precursors, for preparing a medicine intended for the therapeutic use c q the treatment of addicted humans beings, for instance dependance of nicotine caused by smoking of tobacco, gluing of nicotine stamps on the skin, plasters using nicotine inhalers sprays, injections, etc Similarv the invention can be used for the treatment of other forms of addiction caused by the consumption of mateπal or foods alien to the human body like coffee, tea. alcohol, etc. and all kind of drugs The sex steroid precursors dehydroepiandrosterone (DHEA) and dehydroepi- androsteronsulfate (DHEAS) are major natural adrenal secretor ' products in humans They are well known substances which in the body are converted into active hormones like testosteron and estrogen, which substances are essential for many critical functions such as regulating libido metabolism, etc Since these compounds are converted in the body into acϋve hormones they are indicated in this specification as precursors DHEA and DHEAS are natural products but can also be prepared synthetically Analogues of the above mentioned precursors are synthetically prepared molecules eg fluoro- or bromo-epiandrosteron Certain analogues can be conλ'erted in vivo into one of the above mentioned precursors their active componants or hormones If within the scope of this specification reference is made to DHEA. the other above mentioned precursors and analogues are included as well The plasma concentration of DHEAS which is the second abundant steroid in humans, undergoes tiie most marked age-related decline of any known steroid. In the body of a 25 year old human DHEAS Is present in abundance In micrograms per milliliter up to about 4.5 for female and 7.9 for man. After this age. the concentration lowers down to about 10% at the age of 80 The body uses these precursors to create sex hormones, but in many publications it is presumed that these precursors are also engaged in other body-activities Numerous publications are dedicated to the possible effects of the application of DHEA. also in some patent publications various therapeutic effects of its administrauon are pointed out. for instance as anti-carcinogen . EP-0627921. for utilization with cancer of the uterus WO-9416709. w th lupus ervthematosus WO-9408589 and eye diseases WO-9404155. Furthermore literature exists concerning treatment of breast cancer (Lancet2-395-398- 1971 ) , and concerning obesity. Concerning blood concentrations of twenty different steroids in relation to the concentrauonof the intemeural fluid low affinity interaction of steroids with neuronal membrane-bound receptors (J. Steroid Biochem Molec. Biol Vol48.No4 1994), about the lower ESTFUOL and DHEAS level noticed in pregnant methadone addicted woman (Eur J Obstet Gynecol..23. pages 67-73) 1986) It was concluded that methadone (and probably heroine) use duπng pregnacv was accompanied by a reduction of circulating DHEAS levels Although a link seems to exist between DHEA and methadone. it has never been suggested that administering DHEA might cure methadone or heroin addiction, neither nicotine or other food related addiction. Surpnsingly it has been observed that addiction to nicotine, or other addictive drugs can be cured by administering or in whatever way bringing m the blood of an addicted person an effective amount of DHEA equally has been established that DHEA can be used for the preparation of a medicine. intended for therapeutic use. aimed at the detoxication from addicting substances particulary nicotine. It was found that an overdose of DHEA will have a maximum effect, which w ll not necessarily mean that the level of DHEA in the blood should be brought at or higher than, youth related levels It is pointed out that for each individual the proper level of DHEA must be established, which will be for most of the time a level that is higher than generally present in the blood for the persons at that age The advantage of the invention is that if the right person-depending quantity will be administrated, the detoxication process will be easy and painless The effectiveness of the present invention can easily be demonstrated at short notice by treatment of addicted persons, choosen at random Another aspect of the invention concerns food or refreshments fortified with an effective amount of DHEA , preferably foodstuffs that are industrially prepared and normally consumed on a daily basis eg chewing gum candy, soup, margaπne or reduced-fat varieties In whatever way use shall be made of t e present invention, no risk exist that the former addicted person will unvoluntaπly return to his bad habit for if he chooses to do so. he can just start another treatment according to this invention From now on. those who want or not want to continue a certain consumption, can do so by a decision based on free will It has been observed that this invention works out differently per addicting product and differently per person While in respect of nicotine a certain disgust against smoking will be developped. the effects on cafeine and alcohol are milder and softer, creating a certain indifference Furthermore as the invention will have a beneficial effect on general health apart from diminishing lots ot suffering, it will generate major savings on state health-care budgets The positive effects of the invention will come quicker by (partial) oral subhngual consumption of the appropπate amount of the age-dependent mentioned overdose varying from 100 up to 300 or even more milligram per day, like 10 times per day 30 milligram. Regular medical control is advisable including bloodanalysis to ensure the absence of high levels of prostate specific antigen (PSA check) and it could be advantageous to combine the treatment with antioxidants like the vitamins E. C, and Coenzymes The precursors themselves mentioned above can have a slight addicting effect. However gradual reduction of the intake to avoid another addiction will not cause problems comparable to nicotine addiction. Furthermore, sex steroide precursors are in all liturature considered harmless for human beings with acceptable PSA levels. The positive effects could be diminished by parallel intake of hormones and possibly by the consumption of meat, because of a possible presence of non- or anti-coherent hormones. This is another reason to have the invention applied under medical control, which at the same time will ensure a safeguard in respect of the quality and oπgin of the precursor(s) to be administered. EXAMPLE: Man. age 59. 1 .80M. 84 kilo, healthy, hectic lifestyle, was smoking during 40 years some 20 up to at last 70 cigarettes a day and his coffee consumption was on an average of 1 liter a day. He did numerous unsuccessful! trials to stop both habits. He started on april the 19th. 1995 after a medical check-up including blood (PSA) analysis with oral sublingual intake of 300 mg DHEA per day (10 times 30mg). After the first day of treatment already a slight but tracable indifference for cigarettes and consumption of coffee was observed. After weeks Tea. chocolat. sugar and alcohol lost some of their attraction. After 3 weeks a strong reduchon oi cigarette consumption resulted without any effort and after some 8 weeks followed resentment. During the first year, abrupt stopping of the DHEA intake (performed as a test about 5 times) brought back the gπeving for the mentioned products, but less and less so. Concerning coffee and other products the result was indifference. After 10 months the intake oi DHEA was reduced to 200 milligram per day. After 15 months to 100 milligram per day in about 6 or 7 sublingual pills of 15 milligram. In general the sublingual DHEA in <e occurred on moments when formerly a cigarette would have been taken, . uπng the months less and less of DHEA was sufficient. After almost 2 years of almost finished treatment (actually 5 milligram DHEA per day is taken), the important difference with persons who quitted smoking just by will power or following another method, cigarettes neighter their smell have anv inviting value. The opposite m a fact. Coffee is dimished to 2 cups a day without problem.

Claims: CLAIMS: 1) Process for curing addicted human beings by admistering an effective amount of a sex steroid precursor . 2) Process according to claim 1 in which the sex steroid precursor is DHEA ( as defined in the specification). 3) Use of a sex steroid precursor for preparing a medecine for curing addicted human beings. 4) Use according to claim 3 in which the sex steroid precursor 5) Process and use according to anyone of claims 1 -4 for the treatment of nicotine addicted human beings. 6) Process and use according to anyone of claims 1 -5 for the treatment of food related addiction. 7) Foodstuffs comprising an effective amount of DHEA.

Inventors: NEFKENS GERARDUS JOANNES EMILE, NOIJEN HELGA MANUELA, NEFKENS, GERARDUS, JOANNES, EMILE, MARIA, NOIJEN, HELGA, MANUELA
Applicants: NEFKENS GERARDUS JOANNES EMILE, NOIJEN HELGA MANUELA, NEFKENS, GERARDUS, JOANNES, EMILE, MARIA, NOIJEN, HELGA, MANUELA
Application year: 1997
Main classification: A61K31
IPC codes: A61K31