3-PHENYL-FURAN-(5H)-2-ONE AND DIHYDROFURAN-2-ONE DERIVATIVES AS ANTIBACTERIAL AGENTS

Abstract: The invention concerns a compound of formula (I), wherein, for example: R<1> is of the formula -NHC(=O)(1-4C)alkyl; R<2> and R<3> are hydrogen or fluoro; R<4> and R<5> are hydrogen or methyl; >A-B- is of the formula >C=CH-, >CHCH2, or >C(OH)CH2- (> represents two single bonds); D is O, S, SO, SO2 or -NR<7>; wherein R<7> is hydrogen, R<10>CO-, R<10>SO2-, R<a>OC(R<b>)=CH(C=O)-, R<c>C(=O)C(=O)-, R<d>N=C(R<e>)C(=O)-, R<f>NHC(R<g>)=CHC(=O)- or R<14>CH(R<13>)(CH2)m-; wherein R<10> is (1-6C)alkyl [optionally substituted by, for example, hydroxy or (1-6C)alkanoyl], R<11>C(O)O(1-6C)alkyl or R<12>O-; wherein R <11> is optionally substituted (1-6C)alkyl; R<12> is optionally substituted (1-6C)alkyl; R<a>, R<b>, R<c>, R<d>, R<e>, R<f>, R<g> are (1-6C)alkyl; m is 0 or 1; R<13> is cyano; R<14> is hydrogen or (1-4C)alkyl; >X-Y- is of the formula >C=CH- or >CHCH2-; and pharmaceutically acceptable salts thereof; processes for the preparation; pharmaceutical compositions containing them and their use as antibacterial agents.

Description: 3-PHENYL-FURAN-(5H)-2-ONE AND DIHYDROFURAN-2-ONE DERIVATIVES AS ANTIBACTE- RIAL AGENTS The present invention relates to antibiotic compounds and in particular to antibiotic compounds containing a furanone ring. This invention further relates to processes for their preparation, to intermediates useful in their preparation, to their use as therapeutic agents and to pharmaceutical compositions containing them. The international microbiological community continues to express serious concern that the evolution of antibiotic resistance could result in strains against which currently available antibacterial agents will be ineffective. In general, bacterial pathogens may be classified as either Gram-positive or Gram-negative pathogens. Antibiotic compounds with effective activity against both Gram-positive and Gram-negative pathogens are generally regarded as having a broad spectrum of activity. The compounds of the present invention are regarded primarily as effective against Gram-positive pathogens because of their particularly good activity against such pathogens. Gram-positive pathogens, for example Staphylococci, Enterococci, Streptococci and mycobacteria, are particularly important because ofthe development of resistant strains which are both difficult to treat and difficult to eradicate from the hospital environment once established. Examples of such strains are methicillin resistant staphylococcus (MRS A), methicillin resistant coagulase negative staphylococci (MRCNS), penicillin resistant streptococcus pneumoniae and multiply resistant Enterococcus faecium. The major clinically effective antibiotic for treatment of such resistant Gram-positive pathogens is vancomycin. Vancomycin is a glycopeptide and is associated with nephrotoxicity and ototoxicity. Furthermore, and most importantly, antibacterial resistance to vancomycin and other glycopeptides is also appearing. This resistance is increasing at a steady rate rendering these agents less and less effective in the treatment of Gram-positive pathogens. The present inventors have discovered a class of antibiotic compounds containing a furanone ring which has useful activity against Gram-positive pathogens including MRSA and MRCNS and, in particular, against various strains exhibiting resistance to vancomycin and against E. faecium strains resistant to both aminoglycosides and clinically used β-lactams. We have now discovered a range of compounds that is not suggested by the art and which has good activity against a broad range of Gram-positive pathogens including organisms known to be resistant to most commonly used antibiotics. In comparison with compounds described in the art (for example Walter A. Gregory et al in J.Med.Chem. 1990, 33, 2569-2578 and Chung-Ho Park et al in J.Med.Chem. 1992, 35, 1156-1165) the compounds also possess a favourable toxicological profile. Accordingly, there is provided a compound ofthe formula (I) :- (I) wherein: R 1 is hydroxy or ofthe formula -NHC(=O)(l-4C)alkyl or -NHS(O) n (l-4C)alkyl wherein n is 0, 1 or 2; R 2 and R 3 are independently hydrogen or fluoro; R * and R D are independently hydrogen or methyl >A-B- is ofthe formula >C=CH- , >CHCH 2 - , or >C(OH)CH 2 - (> represents two single bonds); D is O, S, SO, SO 2 or NR 7 ; R is hydrogen, cyano, 2-((l-4C)alkoxycarbonyl)ethenyl, 2-cyanoethenyl, 2-cyano-2-((l -4C)alkyl)ethenyl, 2-((l-4C)alkylaminocarbonyl)ethenyl, AR (as defined hereinbelow) or a tetrazole ring system (optionally mono-substituted in the 1 - or 2- position of the tetrazole ring) wherein the tetrazole ring system is joined to the nitrogen in NR by a ring carbon atom; or R 7 is of the formula R IO CO- , R ,0 SO 2 - or R I0 CS- wherein R 10 is AR (as defined hereinbelow), cyclopentyl or cyclohexyl (wherein the last two- mentioned cycloalkyl rings are optionally mono- or disubstituted by substituents independently selected from (l-4C)alkyl (including geminal disubstitution), hydroxy, (l-4C)alkoxy, (l-4C)alkylthio, acetamido, (l-4C)alkanoyl, cyano and trifluoromethyl), (l-4C)alkoxy carbonyl, hydrogen, amino, trifluoromethyl, (l-4C)alkylamino, di((l-4C)alkyl)amino, 2,3-dihydro-5-oxothiazolo-[3,2-A]pyrimidin-6-yl, 2-(2-furyI)ethenyl, 2-(2-thienyl)ethenyl, 2-phenylethenyl (wherein the phenyl substituent is optionally substituted by up to three substituents independently selected from (l-4C)alkoxy, halo and cyano), 3,4- dihydropyran-2-yl, coumal-5-yl, 5-methoxy-4-oxopyran-2-yl, N-acetylpyrrolidin-2-yl, 5-oxo- tetrahydrofuran-2-yl, benzopyranone or ( 1 - 1 OQalkyl [wherein (1-10C)alkyI is optionally substituted by hydroxy, cyano, halo, (l -lOC)alkoxy, benzyloxy, trifluoromethyl, ( 1 -4C)alkoxy-( 1 -4C)alkoxy, ( 1 -4C)alkoxy-( 1 -4C)alkoxy-( 1 -4C)alkoxy , ( 1 -6C)alkanoy 1. (l-4C)alkoxycarbonyl, amino, (l-4C)alkylamino, di((l-4C)alkyl)amino, (1- 6C)alkanoylamino, (l -4C)alkoxycarbonylamino, N-(l-4C)alkyl-N-(2-6C)alkanoylamino, (1 - 4C)alkylS(O) p NH-, (l-4C)alkylS(O) p ((l-4C)alkyl)NH-, fluoro(l -4C)alkylS(O) p NH-, fluoro(l-4C)alkylS(O) p ((l-4C)alkyl)NH-, phosphono, (l-4C)alkoxy(hydroxy)phosphoryl, di-(l-4C)alkoxyphosphoryl, (l-4C)alkylS(O) q - , phenylS(O) q - (wherein the phenyl group is optionally substituted by up to three substituents independently selected from (l -4C)alkoxy, halo and cyano), or CY (as defined hereinbelow), wherein p is 1 or 2 and q is 0, 1 or 2] ; or R 10 is ofthe formula R 1 'C(O)O(l-6C)alkyl wherein R 1 ' is an optionally substituted 5- or 6-membered heteroaryl, optionally substituted phenyl, (l-4C)a!kylamino, benzyloxy-(l-4C)alkyl or optionally substituted (1-1 OQalkyl; or R is ofthe formula R O- wherein R is optionally substituted (1 -6C)alkyl; or R 7 is of the formula R a OC(R b )=CH(C=O)-, R c C(-O)C(=O)-, R d N=C(R e )C(=O)- or R f NHC(Rg)=CHC(=O)- wherein R a is (l-6C)alkyl, R b is hydrogen or (l -6C)alkyl, or R a and R together form a (3-4C)alkylene chain, R c is hydrogen, (l-6C)alkyl, hydroxy(l-6C)alkyl, (l-6C)a!koxy(l-6C)alkyl, amino, (l-4C)alkylamino, di-(l-4C)alkylamino, (l-6C)alkoxy, (l-6C)alkoxy(l-6C)aikoxy, hydroxy(2-6C)alkoxy, (l-4C)alkylamino(2-6C)alkoxy, di-(l-4C)alkylamino(2-6C)alkoxy, R d is (1 -6C)alkyl, hydroxy or (l-6C)alkoxy, R e is hydrogen or (l-6C)alkyl, R f is hydrogen, (l-6C)alkyl, optionally substituted phenyl or an optionally substituted 5- or 6-membered heteroaryl and R e is hydrogen or (l-6C)alkyl; or R 7 is of the formula R 14 CH(R 13 ) (CH 2 ) m - wherein m is 0 or 1, R 13 is fluoro, cyano, (l-4Qalkoxy, (l-4C)alkylsulfonyl, (l-4C)alkoxycarbonyl or hydroxy, (provided that when m is 0, R is not fluoro or hydroxy) and R is hydrogen or (l-4C)alkyl; wherein AR is optionally substituted phenyl, optionally substituted phenyl(l-4Qalkyl, optionally substituted 5- or 6-membered heteroaryl, optionally substituted naphthyl or an optionally substituted 5/6 or 6/6 bicyclic heteroaryl ring system, in which the bicyclic heteroaryl ring systems may be linked via an atom in either ofthe rings comprising the bicyclic system, and wherein the mono- and bicyclic heteroaryl ring systems are linked via a ring carbon atom; wherein CY is a 4-, 5- or 6-membered cycloalkyl ring, a 5- or 6-membered cycloalkenyl ring, naphthoxy, thiophen-2-yl, indol-1-yl, indol-3-yl, pyrimidin-2-ylthio, 1 ,4-benzodioxan-6-yl, sulfolan-3-yl, pyridin-2-yl; wherein any ofthe afore-mentioned ring systems in CY may be optionally substituted by up to three substituents independently selected from halo, (l-4C)alkyl (including geminal disubstitution when CY is a cycloalkyl or cycloalkenyl ring), acyl, oxo and nitro-(l-4C)alkyl; >X-Y- is ofthe formula >C=CH- or >CHCH 2 -; and pharmaceutically-acceptable salts thereof. In this specification a '5- or 6-membered heteroaryl' and 'heteroaryl (monocyclic) ring' means a 5- or 6-membered aryl ring wherein 1, 2 or 3 of the ring atoms are selected from nitrogen, oxygen and sulfur. Particular examples of 5- or 6-membered heteroaryl ring systems are furan, pyrrole, pyrazole, imidazole, triazole, pyrimidine, pyridazine, pyridine, isoxazole, oxazole, isothiazole, thiazole and thiophene. In this specification a '5/6 or 6/6 bicyclic heteroaryl ring system' and 'heteroaryl (bicyclic) ring' means an aromatic bicyclic ring system comprising a 6-membered ring fused to either a 5 membered ring or another 6 membered ring, the bicyclic ring system containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur. Particular examples of 5/6 and 6/6 bicyclic ring systems are indole, benzofuran, benzoimidazole, benzothiophene, benzisothiazole, benzoxazole, benzisoxazole, pyridoimidazole, pyrimidoimidazole, quinoline, quinoxaline, quinazoline, phthalazine, cinnoline and naphthyridine. In this specification a '4-, 5- or 6-membered cycloalkyl ring' means a cyclobutyl, cyclopentyl or cyclohexyl ring; and a '5- or 6-membered cycloalkenyl ring' a means cyclpentenyl or cyclohexenyl ring. In this specification the term 'alkyl' includes straight chained and branched structures. For example, (l -6C)alkyl includes propyl, isopropyl and tert-butyl. However, references to individual alkyl groups such as "propyl" are specific for the straight chained version only, and references to individual branched chain alkyl groups such as "isopropyl" are specific for the branched chain version only. A similar convention applies to other radicals, for example halo(l-4C)alkyI includes 1 -bromoethyl and 2-bromoethyl. Particular optional substituents for alkyl, phenyl (and phenyl containing moieties) and naphthyl groups and ring carbon atoms in heteroaryl (mono or bicyclic) rings in R" , R 12 , R 1 and AR include halo, (l-4C)alkyl , hydroxy, nitro, carbamoyl, (l -4C)alkylcarbamoyl, di- ((l-4C)alkyl)carbamoyl, cyano, trifluoromethyl, trifluoromethoxy. amino, (l-4C)alky!amino, di((l-4C)alkyl)amino, (l-4C)alkyl S(O) ., (wherein q is 0, 1 or 2). carboxy, (1- 4C)alkoxycarbonyl, (2-4C)alkenyl, (2-4C)alkynyl, (l-4C)alkanoyl. (l-4C)alkoxy, (1 - 4C)alkanoylamino, benzoylamino, benzoyl, phenyl (optionally substituted by up to three substituents selected from halo, (l-4C)alkoxy or cyano), furan, pyrrole, pyrazole, imidazole, triazole, pyrimidine, pyridazine, pyridine, isoxazole, oxazole. isothiazole, thiazole, thiophene, hydroxyimino(l-4C)alkyl, (l-4C)alkoxyimino(l-4C)alkyl, hydroxy-(l-4C)alkyl. halo-(l- 4C)alkyl, nitro(l-4C)alkyl, amino(l-4C)alkyl, cyano(l-4C)a!kyl, (l-4C)alkanesulfonamido, aminosulfonyl, (l-4C)alkylaminosulfonyl and di-((l-4C)alkyl)aminosulfonyl. The phenyl and naphthyl groups and heteroaryl (mono- or bicyclic) rings in R", R 1 and AR may be mono- or disubstituted on ring carbon atoms with substituents independently selected from the above list of particular optional substituents. Particular optional substituents for ring nitrogen atoms when R is tetrazole, in heteroaryl groups in R" , R 12 , R r and AR, and in the nitrogen-containing rings in CY, which can be substituted without becoming quaternised include (l-4C)alkyl. (2-4C)alkenyl, (2- 4C)alkynyl and ( 1 -4QalkanoyI. Examples of halo groups include fluoro, chloro and bromo; examples of (l-4C)alkyl, include methyl, ethyl, and propyl and isopropyl; examples of (l-6C)alkyl include methyl, ethyl, propyl, isopropyl, pentyl and hexyl; examples of (1-lOQalkyl include methyl, ethyl, propyl, isopropyl, pentyl, hexyl, heptyl, octyl and nonyl; examples of (l-4C)alkylamino include methylamino, ethylamino and propylamino; examples of di-((l-4C)alkyl)amino include dimethylamino, N-ethyl-N-methylamino, diethylamino, N-methyl-N-propylamino and dipropylamino; examples of (l-4C)alkylS(O) q - wherein q is 0, 1 or 2 include methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl and ethylsulfonyl; examples of (l-4C)alkanesulfonyloxy include methylsulfonyloxy, ethylsulfonyloxy and propylsulfonyloxy; examples of (l-4C)alkylthio include methylthio and ethylthio; examples of ( 1 -4C)alkylsulfonyl include methylsulfonyl and ethylsulfonyl; examples of ( 1 - 4C)alkylaminocarbonyloxy include methylaminocarbonyloxy and ethylaminocarbonyloxy; examples of (l-4C)alkanoylamino-(l-4C)alkyl include formamidomethyl, acetamidomethyl and acetamidoethyl; examples of (l-6C)alkoxy-(l -OQalkyl include methoxymethyl, ethoxymethyl and 2 -methoxy ethyl; examples of (l-4C)alkoxycarbonyl include methoxycarbonyl, ethoxycarbonyl and propoxycarbonyl; examples of (2-4C)alkanoyloxy include acetyloxy and propionyloxy; examples of (l-4C)alkoxy include methoxy, ethoxy and propoxy; examples of (l-6C)alkoxy and (1-lOQalkoxy include methoxy, ethoxy, propoxy and pentoxy; examples of hydroxy-(2-6C)alkoxy include 2-hydroxyethoxy and 3-hydroxypropoxy; examples of (l-4C)alkylamino-(2-6C)alkoxy include 2-methylaminoethoxy and 2-ethylaminoethoxy; examples of di-(I-4C)alkylamino-(2- 6C)alkoxy include 2-dimethylaminoethoxy and 2-diethylaminoethoxy; examples of (1 - 4C)alkoxy-(l-4C)alkoxy and (l-6C)alkoxy-(l-6C)alkoxy include methoxymethoxy, 2- methoxyethoxy, 2-ethoxyethoxy and 3 -methoxy propoxy; examples of (l-4C)alkoxy-(l-4C)alkoxy-(l- 4C)alkoxy include 2-(methoxymethoxy)ethoxy, 2-(2-methoxyethoxy)ethoxy; 3-(2- methoxy ethoxy )propoxy and 2-(2-ethoxyethoxy)ethoxy; examples of (l-4C)alkanoylamino and (l-6C)alkanoylamino include formamido, acetamido and propionylamino; examples of (l -4C)alkoxycarbonylamino include methoxycarbonylamino and ethoxycarbonylamino; examples of N-(l-4C)alkyl-N-(l-6C)alkanoylamino include N-methylacetamido, N- ethylacetamido and N-methylpropionamido; examples of (l-4C)alkylS(O) p NH- wherein p is 1 or 2 include methylsulfinylamino, methylsulfonylamino, ethylsulfinylamino and ethylsulfonylamino; examples of (l-4C)alkylS(O) p ((l-4C)alkyl)NH- wherein p is 1 or 2 include methylsulfinylmethylamino, methylsulfonylmethylamino, 2-(ethylsulfinyl)ethylamino and 2-(ethylsulfonyl)ethylamino; examples of fluoro(l-4C)alkylS(O) p NH- wherein p is 1 or 2 include trifluoromethylsulfinylamino and trifluoromethylsulfonylamino; examples of fluoro(l-4C)alkylS(O) p ((l-4C)alkyl)NH- wherein p is 1 or 2 include trifluoromethylsulfinylmethylamino and trifluoromethylsulfonylmethylamino; examples of ( 1 -4C)alkoxy(hydroxy)phosphoryl include methoxy(hydroxy)phosphoryl and ethoxy(hydroxy)phosphoryl ; examples of di-( 1 -4C)alkoxyphosphory 1 include di-methoxyphosphoryl, di-ethoxyphosphoryl and ethoxy(methoxy)phosphoryl; examples of 2-((l-4C)alkoxycarbonyl)ethenyl include 2-(methoxycarbonyl)ethenyl and 2-(ethoxycarbonyl)ethenyl; examples of 2-cyano-2-((l-4C)alkyl)ethenyl include 2-cyano-2-methylethenyl and 2-cyano-2-ethylethenyl; examples of 2-((l - 4C)alkylaminocarbonyl)ethenyl include 2-(methylaminocarbonyl)ethenyl and 2-(ethylaminocarbonyl)ethenyl; examples of benzyloxy(l-4C)alkyl include benzyloxymethyl and benzyloxyethyl; examples of phenyl( 1 -4C)alkyl include benzyl and phenethyl; examples of phenylS(O) q wherein q is 0, 1 or 2 are phenylthio, phenylsulfinyl and phenylsulfonyl respectively; examples of (l-4C)alkylcarbamoyl include methylcarbamoyl and ethylcarbamoyl; examples of di((l-4C)alkyl)carbamoyl include di(methyl)carbamoyl and di(ethyl)carbamoyl; examples of a (3-4C)alkylene chain are trimethylene or tetramethylene; examples of (2-4C)alkenyl include allyl and vinyl; examples of (2-4C)alkynyl include ethynyl and 2-propynyl; examples of (l-4C)alkanoyl and ( 1 -6C)alkanoyl include formyl, acetyl and propionyl; examples of hydroxyimino(l-4C)alkyl include hydroxyiminomethyl, 2- (hydroxyimino)ethyl and l-(hydroxyimino)ethyl; examples of (l -4C)alkoxyimino-(l-4C)alkyl include methoxyiminomethyl, ethoxyiminomethyl, l-(methoxyimino)ethyl and 2- (methoxyimino)ethyl; examples of hydroxy(l-4C)alkyl and hydroxy(l-6C)alkyl include hydroxymethyl, 1 -hydroxyethyl, 2-hydroxyethyl and 3-hydroxypropyl; examples of halo(l- 4C)alkyl include, halomethyl, 1-haloethyl, 2-haloethyl, and 3-halopropyl; examples of nitro(l-4C)alkyl include nitromethyl, 1-nitroethyl, 2-nitroethyl and 3 -nitro propyl; examples of amino(l-4C)alkyl include aminomethyl, 1-aminoethyl, 2-aminoethyl and 3-aminopropyl; examples of cyano(l-4C)alkyl include cyanomethyl, 1-cyanoethyl, 2-cyanoethyl and 3- cyanopropyl; examples of (l-4C)alkanesulfonamido include methanesulfonamido and ethanesulfonamido; examples of (l-4C)alkylaminosulfonyl include methylaminosulfonyl and ethylaminosulfonyl; and examples of di-(l-4C)alkylaminosulfonyl include dimethylaminosulfonyl, diethylaminosulfonyl and N-methyl-N-ethylaminosulfonyl. Suitable pharmaceutically-acceptable salts include acid addition salts such as methanesulfonate, fumarate, hydrochloride, hydrobromide, citrate, maleate and salts formed with phosphoric and sulfuric acid. In another aspect suitable salts are base salts such as an alkali metal salt for example sodium, an alkaline earth metal salt for example calcium or magnesium, an organic amine salt for example triethylamine, morpholine, N- methylpiperidine, N-ethylpiperidine, procaine, dibenzylamine, N,N-dibenzylethylamine or amino acids for example lysine. There may be more than one cation or anion depending on the number of charged functions and the valency of the cations or anions. A preferred pharmaceutically-acceptable salt is the sodium salt. However, to facilitate isolation ofthe salt during preparation, salts which are less soluble in the chosen solvent may be preferred whether pharmaceutically-acceptable or not. The compounds of the formula (I) may be administered in the form of a pro-drug which is broken down in the human or animal body to give a compound of the formula (I). Examples of pro-drugs include in-vivo hydrolysable esters of a compound ofthe formula (I). An in-vivo hydrolysable ester of a compound of the formula (I) containing carboxy or hydroxy group is, for example, a pharmaceutically-acceptable ester which is hydrolysed in the human or animal body to produce the parent acid or alcohol. Suitable pharmaceutically- acceptable esters for carboxy include ( 1 -6C)alkoxymethyl esters for example methoxymethyl, (l-6C)alkanoyloxymethyl esters for example pivaloyloxymethyl, phthalidyl esters, (3- 8C)cycloalkoxycarbonyloxy(l -6C)alkyl esters for example 1-cyclohexylcarbonyloxyethyl; 1 ,3-dioxolen-2-onylmethyl esters for example 5-methyl-l,3-dioxolen-2-onylmethyl; and (l-6C)alkoxycarbonyloxyethyl esters for example 1-methoxycarbonyloxyethyl and may be formed at any carboxy group in the compounds of this invention. An in-vivo hydrolysable ester of a compound of the formula (I) containing a hydroxy group includes inorganic esters such as phosphate esters and α-acyloxyalkyl ethers and related compounds which as a result ofthe in-vivo hydrolysis of the ester breakdown to give the parent hydroxy group. Examples of α-acyloxyalkyl ethers include acetoxymethoxy and 2,2-dimethylpropionyloxymethoxy. A selection of in-vivo hydrolysable ester forming groups for hydroxy include alkanoyl, benzoyl, phenylacetyl and substituted benzoyl and phenylacetyl, alkoxycarbonyl (to give alkyl carbonate esters), dialkylcarbamoyl and N-(dialkylaminoethyl)-N-alkylcarbamoyl (to give carbamates). dialkylaminoacetyl and carboxy acetyl. The compounds ofthe present invention have a chiral centre at the 5-position ofthe furanone ring. The 5(R) enantiomer of formula (IA) is the pharmaceutically active enantiomer : The present invention includes the pure 5(R) enantiomer or diastereoisomer and mixtures ofthe 5(R) and 5(S) enantiomers or diastereoisomers. for example a racemic mixture or equal mixtures of diastereoisomers. If a mixture of 5(R) and 5(S) is used, a larger amount (depending on the ratio ofthe enantiomers or diastereoisomers) will be required to achieve the same effects as the same weight ofthe 5(R) compound. When -A-B- is ofthe formula >CHCH2- (i.e. when the ring is a 3, 4-dihydro furanone ring) there is also a chiral centre at the 3-position. The present invention relates to both the 3R and the 3S diastereoisomers. Furthermore, some compounds of the formula (I) may have other chiral centres, and some compounds of the formula (I) may exist as one or more regioisomers. It is to be understood that the invention encompasses all such optical, diastereo- and regio-isomers that possess antibacterial activity. The invention relates to all tautomeric forms ofthe compounds ofthe formula (I) that possess antibacterial activity. It is also to be understood that certain compounds of the formula (I) can exist in solvated as well as unsolvated forms such as, for example, hydrated forms. It is to be understood that the invention encompasses all such solvated forms which possess antibacterial activity. In a preferred aspect of the invention there is provided a compound of the formula (I) wherein: R' is hydroxy or of the formula -NHC(=O)(l-4C)alkyl or -NHS(O) n (l-4C)alkyl wherein n is 0, 1 or 2; R 2 and R 3 are independently hydrogen or fluoro; R 4 and R 5 are independently hydrogen or methyl; >A-B- is ofthe formula >C=CH-, >CHCH 2 or >C(OH)CH r (> represents two single bonds); D is O, S, SO, SO 2 or -NR 7 ; wherein R 7 is hydrogen, 2-((l-4C)alkoxycarbonyl)ethenyl, 2-((l -4C)alkylaminocarbonyl)ethenyl or optionally substituted: phenyl, phenyl(l-4C)alkyl, 5- or 6-membered heteroaryl, naphthyl or 5/6 or 6/6 bicyclic heteroaryl ring system wherein the heteroaryl ring systems are joined to the nitrogen in NR 7 by a ring carbon atom; or R 7 is of the formula R ,0 CO- or R'°SO 2 - wherein R'°is amino, (l-4C)alkylamino, di((l-4C)alkyl)amino, or (l-6C)alkyl [wherein (1 -6C)alkyl is optionally substituted by hydroxy, cyano, (1-6C) alkanoyl, amino, (l-4C)alkylamino, di-(l-4C) alkylamino, (l-6C)alkanoylamino, N-(l-4C)alkyl-N-(l-6C)alkanoylamino, (l-4C)alkylS(O) p NH-, (l-4C)alkylS(O)p((l-4C)alkyl)NH-, phosphono, (l-4C)alkoxy(hydroxy)phosphoryl, di-(l -4C)alkoxyphosphoryl, or (l-4C)alkylS(O) p wherein p is 1 or 2]; or R 10 is ofthe formula R"C(O)O(l-6C)alkyl wherein R" is optionally substituted 5- or 6- membered heteroaryl, optionally substituted phenyl or optionally substituted (l -6C)alkyl; or R 10 is of the formula R l2 O- wherein R 12 is optionally substituted (l-6C)alkyl; or R 7 is ofthe formula ROC(R b )=CH(C=O)-. R c C(=O)C(=O)-, R d N=C(R')C(=O)- or R*NHC(R 8 )=CHC(=O)- wherein R a is (l-6C)alkyl, R" is hydrogen or (l-6C)alkyl or R a and R b together form a (3-4C)alkylene chain, R c is hydrogen, (l-6C)alkyl, hydroxy(l-6C)alkyl, (l-6C)alkoxy(l-6C)alkyl, amino, ( 1 -4C)alkylamino, di-(l-4C)alkylamino, (1-6C) alkoxy, (1- 6C)alkoxy(l-6C)alkoxy, hydroxy(2-6C)alkoxy, (l-4C)aIkylamino(2-6C)alkoxy, di-(l- 4C)alkylamino(2-6C)alkoxy, R d is (l-όC)alkyl, hydroxy or (l-6C)alkoxy, R c is hydrogen or (l-6C)alkyl, R f is (l-όC)alkyl, phenyl or a 5- or 6-membered heteroaryl and R B is hydrogen or (1 -OQalkyl; or R 7 is ofthe formula R I4 CH(R 13 ) (CH 2 ) m - wherein m is 0 or 1, R 13 is fluoro, cyano, (l-4C)alkoxy, (l -4C)alkylsulfonyl, (l-4C)alkoxycarbonyl or hydroxy; (provided that when m is 0, R π is not fluoro or hydroxy) and R 14 is hydrogen or (l-4C)alkyl; >X-Y- is ofthe formula >C=CH- or >CHCH 2 -; and pharmaceutically-acceptable salts thereof. In the above preferred aspect ofthe invention particular examples a '5- or 6- membered heteroaryl' and 'heteroaryl (monocyclic) ring' are imidazole, triazole, pyrimidine, pyridazine, pyridine, isoxazole, oxazole, isothiazole, thiazole and thiophene. Also in the above preferred aspect ofthe invention particular examples a '5/6 or 6/6 bicyclic heteroaryl ring system' and 'heteroaryl (bicyclic) ring' are benzofuran, benzoimidazole, benzothiophene, benzisothiazole, benzoxazole, benzisoxazole, pyridoimidazole, pyrimidoimidazole, quinoline, quinoxaline, quinazoline, phthalazine, cinnoline and naphthyridine. Also in the above preferred aspect of the invention particular substituents for alkyl and phenyl groups and ring carbon atoms in heteroaryl (mono or bicyclic) rings in R 7 , R" or R 12 include halo, (l-4C)alkyl , hydroxy, nitro, carbamoyl, (l-4C)alkylcarbamoyl, di((l- 4Qalkyl)carbamoyl, cyano, trifluoromethyl, amino, (l-4Qalkylamino, di((l-4C)alkyl)amino, (l-4C)alkyl S(O) p _, (wherein p is 0, 1 or 2), carboxy, (l -4C)alkoxycarbonyl, (2-4C)alkenyl, (2-4C)alkynyl, (l-4C)alkanoyl, (l-4Qalkoxy. (l-4C)alkanoylamino, benzoylamino, hydroxyimino(l-4C)alkyl, (l-4C)alkoxyimino(l-4C)alkyl, hydroxy(l-4C)alkyl, halo(l-4C)alkyl, nitro(l-4C)alkyl, amino(l-4C)alkyl, cyano(l-4C)alkyl, (l-4C)alkanesulfonamido and (1- 4C)alkylaminosulfonyl. In a further preferred aspect ofthe invention there is provided a compound of the formula (I) as defined in the above preferred aspect ofthe invention, wherein R'° when it is (l-6C)alkyl is additionally optionally substituted with (l-6C)alkoxy and benzyloxy; and pharmaceutically-acceptable salts thereof. Particularly preferred compounds of the invention comprise a compound of the formula (I), or a pharmaceutically-acceptable salt thereof, wherein the substituents A, B, D, X, Y and Ri to R5 and other optional substituents mentioned above have the values disclosed hereinbefore, or any of the following values : (a) Preferably R 1 is ofthe formula -NHC(=O)(l-4C)alkyl. Most preferably R 1 is acetamido. (b) Preferably one of R 2 and R 3 is hydrogen and the other is fluoro. (c) Preferably > A-B- is of the formula >C=CH- or >CHCH 2 - . (d) Preferably R 4 and R 5 are hydrogen. (e) Preferably D is O, S or of the formula -NR 7 . (f) Preferred substituents for phenyl and carbon atoms in heteroaryl (mono and bicyclic) ring systems in R 7 and R" include halo, (l-4C)alkyl, hydroxy, nitro, amino, cyano, (l-4C)alkyl S(O)p- and (l-4C)alkoxy. (g) Preferred optional substituents for (l-6C)alkyl in R 11 are hydroxy, cyano, amino, (l-4C)alkylamino, di((l-4C)alkyl)amino, (l-4C)alkylS(O) p (wherein p is 1 or 2), carboxy, (l-4C)alkoxycarbonyl, (l-4C)alkoxy, piperazino or morpholino. (h) Preferred optional substituents for (l-6C)alkyl in R 12 are hydroxy, (l-4C)alkoxy, cyano, amino, (l-4C)alkylamino, di(( 1 -2C)alkyl)amino, (l-4C)alkylS(O) p (wherein p is 1 or (i) Preferably the 5/6 or 6/6 bicyclic ring system in R 7 is unsubstituted. (j) Preferably 5- or 6- membered heteroaryl rings in R" are unsubstituted. (k) Preferably the 5- or 6-membered heteroaryl in R" is pyridyl or imidazol-1 -yl. (1) Preferably R' 2 is (1 -OQalkyl. Most preferably R 12 is methyl or tert-butyl. (m) Preferably R 13 is cyano or fluoro. (n) Preferably R 14 is hydrogen. (o) Preferably R 7 is hydrogen, benzyl, pyridyl, pyrimidyl, imidazolyl, triazolyl or ofthe formula R'°CO-. (p) Preferably R'° is hydroxy(l-4C)alkyl, (MQalkyl, dimethylamino(l-4C)alkyl, (l -4C)alkanoyloxy(l-4C)alkyl, benzyloxy(l-6C)alkyl, (l-5C)alkoxy or 2-cyanoethyl. (q) More preferably R 10 is hydroxymethyl, methyl, dimethylaminomethyl, acetoxymethyl, methoxy, tert-butoxy or 2-cyanoethyl. More preferably R 7 is hydrogen, pyridyl, pyrimidyl, triazolyl, imidazolyl, benzyl, methoxycarbonyl, tert-butoxycarbonyl, hydroxyacetyl, dimethylaminoacetyl or methanesulfonyl. (r) More preferably R 10 is hydroxymethyl, methyl, benzyloxymethyl, acetoxymethyl, methoxy or tert-butoxy. More preferably R 7 is hydrogen, pyridyl, pyrimidyl, triazolyl, imidazolyl, benzyl, methoxycarbonyl, tert-butoxycarbonyl, hydroxyacetyl. dimethylaminoacetyl or methanesulfonyl. (s) Most preferably R l0 is methyl, methoxy. tert-butoxy or hydroxymethyl. Most preferably R 7 is hydrogen, methanesulfonyl, methoxycarbonyl. tert-butoxycarbonyl or hydroxyacetyl. (t) Preferably XY is >C=CH-. Therefore, especially preferred compounds are those defined in the above further preferred aspect ofthe invention wherein R' is ofthe formula -NHC(=O)(l-4C)alkyl ; >A-B- is ofthe formula >C=CH- or >CHCH 2 - and D is O, S or of the formula -NR 7 ; and pharmaceutically-acceptable salts thereof. Ofthe above especially preferred compounds, particular especially preferred compounds ofthe present invention are ofthe formula (I) wherein R' is acetamido; >X-Y- is ofthe formula >C=CH- ; one of R 2 and R 3 is hydrogen and the other is fluoro; >A-B- is ofthe formula >C=CH-; R 4 and R 5 are hydrogen; D is O, S or ofthe formula -NR " ; R 7 is hydrogen or ofthe formula R ,0 CO-; R 10 is hydroxy(l-4C)alkyl, (l-4C)alkanoyloxy(l-4C)alkyl or (1- 5C)alkoxy; and pharmaceutically-acceptable salts thereof. Further particularly preferred compounds of the present invention are those as defined above as particular especially preferred compounds, but with R 2 and R 1 both hydrogen; and pharmaceutically-acceptable salts thereof. Particular compounds of the present invention are: 5R-acetamidomethyl-3-(4-[l -tert-butoxycarbonyl- 1 ,2,5, 6-tetrahydropyrid-4- yl]phenyl)dihydrofuran-2(3H)-one; 5R-acetamidomethyl-3-(4-[l,2,5,6-tetrahydropyrid-4-yl]phenyl)dihydrofuran-2(3H)-one; 5R-acetamidomethyl -3-(4-[l -methoxycarbonyl- 1,2,5, 6-tetrahydropyrid-4-yl]phenyl)- dihydrofuran-2(3H)-one; 5R-acetamidomethyl-3-(4-[l -methylsulfonyl- l,2,5,6-tetrahydropyrid-4-yl]phenyl)- dihydrofuran-2(3H)-one; 5R-acetamidomethyl-3-(4-[l-hydroxyacetyl-l,2,5,6-tetrahydropyrid-4-yl]phenyl)- dihydrofuran-2(3H)-one; 5R-acetamidomethyl-3-(4-[ 1 -tert-butoxycarbonyl- 1 ,2,5 ,6-tetrahydropyrid-4-yl]phenyl)furan- 2(5H)-one; 5R-acetamidomethyl-3-(4-[l,2,5,6-tetrahydropyrid-4-yl]phenyl)furan-2(5H)-one; 5R-acetamidomethyl-3-(4-[l-methylsulfonyl-l,2,5,6-tctrahydropyrid-4-yl]phenyl)-furan- 2(5H)-one; 5R-acetamidomethyl-3-(4-[l -hydroxyacetyl- 1,2,5, 6-tetrahydropyrid-4-yl]phenyl)-furan- 2(5H)-one; 5R-acetamidomethyl-3-(4-[l-acetyloxymethylcarbonyl-l,2,5,6-tetrahydropyrid-4- yl]phenyl)furan-2(5H)-one; 5R-acetamidomethyl-3-(4-[l-dimethylaminoacetoxymethylcarbony 1-1 ,2, 5,6-tetrahydropyrid- 4-yl]phenyl)furan-2(5H)-one; 5R-acetamidomethyl-3-(4-[l -methoxyethylcarbonyloxyacetyl-l,2,5,6-tetrahydropyrid-4- yl]phenyl)furan-2(5H)-one; 5R-acetamidomethyl-3-(4-[l-hydroxyacetyloxyacetyl- 1,2,5, 6-tetrahydropyrid-4- yl]phenyl)furan-2(5H)-one; 5R-acetamidomethyl-3-(4-[l-{4-pyridyl}-l,2,5,6-tetrahydropyrid-4-yl]phenyl)furan-2(5H)- one; 5R-acetamidomethyl-3-(4-[l-{2-pyridyl}-l,2,5,6-tetrahydropyrid-4-yl]phenyl)furan-2(5H)- one; 5R-acetamidomethyl-3-(4-[l-benzyloxyacetyl-l,2,5,6-tetrahydropyrid-4-yl]phenyl)furan- 2(5H)-one; 5R-acetamidomethyl-3-(4-[l-{pyrimid-2-yl}-l,2,5,6-tetrahydropyrid-4-yl]phenyl)-furan- 2(5H)-one; 5R-acetamidomethyl-3-(4-[2,3-dihydropyran-4-yl]phenyl)furan-2(5H)-one; 5R-acetamidomethyl-3-(4-[2,3-dihydrothiopyran-4-yl]phenyl)furan-2(5H)-one; 5R-acetamidomethyl-3-(3-fluoro-4-[2,3-dihydropyran-4-yl]phenyl)furan-2(5H)-one; 5R-acetamidomethyl-3-(3-fluoro-4-[2,3-dihydrothiopyran-4-yl]phenyl)furan-2(5H)-one; 5R-acetamidomethyl-3-(3-fluoro-4-[l-tert-butoxycarbonyl-l,2,5,6-tetrahydropyrid-4- yl]phenyl)furan-2(5H)-one; 5R-acetamidomethyl-3-(3-fluoro-4-[l,2,5,6-tetrahydropyrid-4-yI]phenyl)furan-2(5H)-one; 5R-acetamidomethyl-3-(3-fluoro-4-[l-acetyloxymethylcarbonyl-l,2,5,6-tetrahydropyrid-4- yl]phenyl)-furan-2(5H)-one; 5R-acetamidomethyl-3-(3-fluoro-4-[l -hydroxyacetyl- l,2,5,6-tetrahydropyrid-4-yl]phenyl)- furan-2(5H)-one; or pharmaceutically-acceptable salts thereof. In a further aspect the present invention provides a process for preparing a compound of formula (I) or a pharmaceutically-acceptable salt thereof. The compounds of formula (I) may be prepared by deprotecting a compound of formula (II): (II) wherein R 2 -R 5 and >X-Y- are as hereinabove defined, R 20 is R' or protected R 1 , >Aι-B]- is >A-B- or protected >C(OH)CH 2 - and D| is D in which functional groups are optionally protected; and thereafter, if necessary, forming a pharmaceutically-acceptable salt. Protecting groups may be removed by any convenient method as described in the literature or known to the skilled chemist as appropriate for the removal of the protecting group in question, such methods being chosen so as to effect removal ofthe protecting group with minimum disturbance of groups elsewhere in the molecule. Specific examples of protecting groups are given below for the sake of convenience, in which "lower" signifies that the group to which it is applied preferably has 1-4 carbon atoms. It will be understood that these examples are not exhaustive. Where specific examples of methods for the removal of protecting groups are given below these are similarly not exhaustive. The use of protecting groups and methods of deprotection not specifically mentioned is of course within the scope ofthe invention. A carboxy protecting group may be the residue of an ester-forming aliphatic or araliphatic alcohol or of an ester- forming silanol (the said alcohol or silanol preferably containing 1-20 carbon atoms). Examples of carboxy protecting groups include straight or branched chain (l-12C)alkyl groups (eg isopropyl, t-butyl); lower alkoxy lower alkyl groups (eg methoxymethyl, ethoxymethyl, isobutoxymethyl; lower aliphatic acyloxy lower alkyl groups, (eg acetoxymethyl, propionyloxymethyl, butyryloxymethyl, pivaloyloxymethyl); lower alkoxycarbonyloxy lower alkyl groups (eg 1 -methoxycarbonyloxyethyl, 1-ethoxycarbonyloxyethyl); aryl lower alkyl groups (eg p-methoxybenzyl, o-nitrobenzyl, E-nitrobenzyl, benzhydryl and phthalidyl); tri(lower alkyl)silyl groups (eg trimethylsilyl and t-butyldimethylsilyl); tri(lower alkyl)silyl lower alkyl groups (eg irimethylsilylethyl); and (2-6C)alkenyl groups (eg allyl and vinylethyl). Methods particularly appropriate for the removal of carboxyl protecting groups include for example acid-, metal- or enzymically-catalysed hydrolysis. Examples of hydroxy protecting groups include lower alkenyl groups (eg allyl); lower alkanoyl groups (eg acetyl); lower alkoxycarbonyl groups (eg t-butoxycarbonyl); lower alkenyloxycarbonyl groups (eg allyloxycarbonyl); aryl lower alkoxycarbonyl groups (eg benzoyloxycarbony 1 , r>methoxybenzy loxy carbony 1 , o-nitrobenzy loxycarbony 1 , r>nitrobenzyloxycarbonyl); tri lower alkyl/arylsilyl groups (eg trimethylsilyl, t-butyldimethylsilyl, t-butyldiphenylsilyl); aryl lower alkyl groups (eg benzyl) groups; and triaryl lower alkyl groups (eg triphenylmethyl). Examples of amino protecting groups include formyl, aralkyl groups (eg benzyl and substituted benzyl, eg r>methoxybenzyl, nitrobenzyl and 2,4-dimethoxybenzyl, and triphenylmethyl); di-p-anisylmethyl and furylmethyl groups; lower alkoxycarbonyl (eg t-butoxycarbonyl); lower alkenyloxycarbonyl (eg allyloxycarbonyl); aryl lower alkoxycarbonyl groups (eg benzyloxycarbonyl, r>methoxybenzyloxycarbonyl, o-nitrobenzy loxycarbonyl, r>nitrobenzy loxy carbonyl; trialkylsilyl (eg trimethylsilyl and t-butyldimethylsilyl); alkylidene (eg methylidene); benzylidene and substituted benzylidene groups. Methods appropriate for removal of hydroxy and amino protecting groups include, for example, acid-, metal- or enzymically-catalysed hydrolysis, for groups such as o-nitrobenzyloxycarbonyl, photolytically and for groups such as silyl groups, fluoride. Examples of protecting groups for amide groups include aralkoxymethyl (eg. benzyloxymethyl and substituted benzyloxymethyl); alkoxymethyl (eg. methoxymethyl and trimethylsilylethoxymethyl); tri alkyl/arylsilyl (eg. trimethylsilyl, t-butyldimethylsilyl, t- butyldiphenylsilyl); tri alkyl/arylsilyloxymethyl (eg. t-butyldimethylsilyloxymethyl, t-butyldiphenylsilyloxymethyl); 4-alkoxyphenyl (eg. 4-methoxyphenyl); 2,4-di(alkoxy)phenyl (eg. 2,4-dimethoxyphenyl); 4-alkoxybenzyl (eg. 4-methoxybenzyl); 2,4-di(alkoxy)benzyl (eg. 2,4-di(methoxy)benzyl); and alk-1-enyl (eg. allyl, but-1-enyl and substituted vinyl eg. 2- phenylvinyl). Aralkoxymethyl, groups may be introduced onto the amide group by reacting the latter group with the appropriate aralkoxymethyl chloride, and removed by catalytic hydrogenation. Alkoxymethyl, tri alkyl/arylsilyl and tri alkyl/silyl groups may be introduced by reacting the amide with the appropriate chloride and removing with acid, or in the case of the silyl containing groups fluoride ions. The alkoxyphenyl and alkoxybenzyl groups are conveniently introduced by arylation or alkylation with an appropriate halide and removed by oxidation with eerie ammonium nitrate. Finally alk-1-enyl groups may be introduced by reacting the amide with the appropriate aldehyde and removed with acid. For further examples of protecting groups see one of the many general texts on the subject, for example, 'Protective Groups in Organic Synthesis' by Theodora Green (publisher: John Wiley & Sons). In another aspect ofthe present invention the compounds of the formulae (I) and (II) and pharmaceutically-acceptable salts thereof can be prepared: a) by modifying a substituent in or introducing a substituent into another compound of the formula (I) or (II); b) when R 20 is of the formula -NHS(O)„(l-4C)alkyl, wherein n is lor 2, by oxidising a compound ofthe formula (I) or (II) wherein n is 0 or, when n is 2 by oxidising a compound of the formula (I) or (II) wherein n is 1 ; c) when R 20 is ofthe formula -NHC(=O)(l-4C)alkyl or -NHS(O) n (l-4C)alkyl, and >A,-B,- is >C=C-, >CHCH 2 -, or protected >C(OH)CH 2 - reacting a compound of the formula (III) with a compound of formula (IV): (III) (IV) d) when R 20 is hydroxy and >X-Y- is >CHCH 2 -: (i) by reacting a compound of the formula (V) wherein >A]-Bι- is >C=CH-, >CHCH 2 - or protected >C(OH)CH 2. with a compound of formula (VI): (V) (VI) or (ii) by reacting a compound of the formula (V) with a compound of the formula (VII): (VII) e) when >Aι-Bι- is >C=CH-, by reacting a compound of the formula (VIII) with a compound ofthe formula (IX): (VIII) (IX) f) when >Aι-B|- is >CHCH 2 - and >X-Y- is >CHCH 2 - , by catalytic hydrogenation of a compound ofthe formula (I) or (II) wherein >Ai-B r is >C=CH- and >X-Y is >CHCH 2 -; g) when >A)-Bι- is >C=CH- and >X-Y- is >CHCH 2 -, by elimination ofthe elements of water, or HOCOR 23 , or HOSO 2 R 24 from a compound ofthe formula (X): h) when >A|-Bι- is >C=CH- and >X-Y- is >CH=CH-, by elimination of the elements of water, HOCOR 23 or HOSO 2 R 24 from a compound ofthe formula (X) wherein >X-Y- is >C(OR 25 )-CH 2 -; i) when >A|-B,- is >C=CH- and >X-Y- is >C=CH- by elimination of PhSOH from a compound ofthe formula (XI); (XI) j) when D is NR 7 and R 7 is R ,0 CO- , R l0 S(O) n - or R 10 CS- , by reacting a compound of the formula (XII) wherein >Ai-B r is >C=CH-, >CHCH 2 . or protected >C(OH)CH r , with a compound ofthe formula (XIII), (XIV) or (XV) respectively wherein n is 2: R 10 COL 4 R 10 SO n L 4a R 10 CSL 4b (XII) (XIII) (XIV) (XV) k) when R 20 is of the formula -N(CO 2 R 26 )CO(l-4C)alkyl; from a compound of the formula (I) and (II) wherein R 1 or R 20 is hydroxy wherein R 2 -R 5 are as hereinabove defined, R 19 is -C(=O)(l-4C)alkyl or -S(O)„(l-4C)alkyl, R 2 ' is hydrogen or (l-6C)alkyl, R 22 is a protecting group, R 23 is (l-4C)alkyl, R 24 is an optionally substituted phenyl group and R 25 is hydrogen, (l-5C)alkanoyl or arylsulfonyl. R26 is (l-4C)alkyl or benzyl; n is 0, 1 or 2 unless otherwise stated; L 1 , L 2 and L 4a are leaving groups, L 4b is a leaving group (for example (l-4Qalkoxy), L 3 is an iodo or triflate leaving group, L 4 is hydroxy or a leaving group and Z is a trialkyltin residue, a boronate acid or ester residue or a zinc monohalide and thereafter if necessary: i) removing any protecting groups; ii) forming a pharmaceutically-acceptable salt. Methods for converting substituents into other substituents are known in the art. For example an alkylthio group may be oxidised to an alkylsulfinyl or alkysulfonyl group, a cyano group reduced to an amino group, a nitro group reduced to an amino group, a hydroxy group alkylated to a methoxy group, a bromo group converted to an alkylthio group or a carbonyl group converted to a thiocarbonyl group (for example using Lawsson's reagent). Compounds ofthe formula (I) or (II) wherein R 1 or R 20 is -NHS(O) n (l-4C)alkyl can be prepared by oxidising a compound of the formula (I) or (II) with standard reagents known in the art for the oxidation of a thio group to a sulfinyl or sulfonyl group. For example, a thio group may be oxidised to a sulfinyl group with a peracid such as m-chloroperoxybenzoic acid and oxidising agents such as potassium permanganate will convert a thio group to a sulfonyl group. Compounds of the formula (I) or (II) wherein R 1 or R 20 is -NHS(l-4C)alkyl can be prepared by reacting compounds ofthe formula (III) with a reagent such as (l-4C)alkylSCl. Standard reaction conditions for the acetylation of an amine group in a compound of the formula (III) or its conversion to a sulfonamido group are known in the art. For example, the amino group can be acetylated to give an acetamido group using the Schotten-Baumann procedure; reacting the compound ofthe formula (III) with acetic anhydride in aqueous sodium hydroxide and THF in a temperature range of 0° to 60°C, preferably between 0°C and ambient temperature. Preferably the acylation is carried out in situ following the catalytic hydrogenation of a compound ofthe formula (IIIA) (below), by performing the hydrogenation in the presence of acetic anhydride. A compound ofthe formula (III) could, for example, be converted into a compound ofthe formula (I) or (II) wherein R' or R is (l-4C)alkylSO2NH- by reacting the compound of the formula (III) with a sulfonyl chloride. For example, by reacting the compound ofthe formula (III) with mesyl chloride in a mild base such as pyridine. Alternatively, compounds ofthe formula (I) or (II) wherein R 1 or R^O is (l-4C)alkylSO2NH- or (l-4C)alkylSONH- may be prepared by reacting a compound ofthe formula (III) with a compound ofthe formula (IV) wherein L' is a phthalimido group. The compound ofthe formula (IV) wherein L 1 is phthalimido may be prepared by oxidising a compound ofthe formula (IV A): (IVA) with standard oxidising agents known for the conversion of a thio group to a sulfinyl or sulfonyl group. Compounds ofthe formula (IVA) can be prepared by reacting phthalimide with an alkylthiochloride (( 1 -4C)alkylSCl). A compound ofthe formula (III) may be prepared by reducing a compound ofthe formula (IIIA): (IIIA) wherein R 2 -R 5 are as hereinabove defined, and >A]-Bι- is >C=CH-, >CHCH 2 - or protected >C(OH)CH 2 -. Suitable reducing agents include triethylamine/hydrogen sulfide, triphenylphosphine and phosphite ester. More specifically a compound of the formula (IIIA) may be converted to a compound ofthe formula (III) by heating it in an aprotic solvent, such as 1 ,2-dimethoxyethane, in the presence of P(OMe)3 and subsequently in 6N aqueous hydrochloric acid. For further details on the reduction of azides to amines see USP 4,705,799. A compound of the formula (IIIA) may be reduced and converted to a compound of the formula (I) or (II) in sjtu using acetic anhydride in DMF. A compound ofthe formula (IIIA) may be prepared by reacting a compound of the formula (IIIB): (IIIB) wherein R 26 is mesyloxy or tosyloxy, with a source of azide. For example, by reacting (IIIB) with sodium azide in an inert solvent such as DMF in a temperature range of ambient to 100°C, normally in the region of 75°C - 85°C. A compound ofthe formula (IIIB) may be prepared by converting the hydroxy group in a compound ofthe formula (I) or (II) wherein R 1 or R 20 is hydroxy into a tosyloxy or mesyloxy group by standard methods known in the art. For example, by reacting the compound ofthe formula (I) or (II) with tosyl chloride or mesyl chloride in the presence of a mild base such as triethylamine or pyridine. Alternatively, a compound ofthe formula (III) may be prepared using similar processes to those used hereinabove and hereinafter for the preparation of compounds of the formulae (I) and (II), wherein R 20 is amino. Compounds ofthe formulae (V) and (VI) are conveniently reacted together in the presence of a strong base such as lithium hexamethyldisilazide or lithium diisopropylamide. The reaction is conveniently carried out in an inert solvent such as tetrahydrofuran (THF), dimethylformamide (DMF), N,N'-dimethylpropyleneurea (DMPU) or NMP in a temperature range of -78°C to -50°C for the deprotonation. Suitable values for R 21 include hydrogen, methyl and ethyl and suitable values for L 2 include iodo and tosyloxy. The intermediate product from the alkylation is cyclised to the final product of the formula (I) or (II) wherein >X-Y- is >CHCH 2 - and R 1 or R 20 is hydroxy, by heating it in aqueous acid, for example 5N hydrochloric acid, together with an organic co-solvent such as tetrahydrofuran. Compounds ofthe formula (V) and (VII) are also conveniently reacted together in the presence of lithium diisopropylamide or lithium hexamethyldisilazide as above. The isolated product of this reaction may be cyclised to a compound ofthe formula (II) wherein >X-Y- is >CHCH 2 - and R 20 is -OR 22 by heating this intermediate product in an aqueous acid as the solvent. When R 22 is benzyl or a similar protecting group and >A]-Bι- is >CHCH 2 -, - OR 22 may be deprotected by hydrogenation using methods known in the art and when > A \ - B]- is >C=CH- by transfer hydrogenation, for example with ammonium formate. A compound of the formula (V) is conveniently prepared by coupling a compound ofthe formula (VA) with a compound ofthe formula (IX): (VA) wherein R 2 - R 5 , R 21, L 3 , Z and Di are as hereinabove defined. The reaction between compounds ofthe formulae (VA) and (IX), wherein Z is trialkyltin and L 3 is triflate is conveniently carried out in the presence of a palladium (0) catalyst such as Pd(PPh 3 ) 4 or Pd(dba) 3 in a temperature range of 0-115°C. Preferably the trialkyltin group is trimethyltin. When Z is a boronate acid or ester, the reaction may be carried out under conditions known for the Suzuki reaction i.e. in the presence of a palladium (0) catalyst such as Pd(PPh 3 ) 4 or Pd(dba) 3 , in a water-miscible organic solvent such as dimethylformamide or 1 ,2- di methoxy ethane and in the presence of a mild base such as sodium acetate or sodium bicarbonate which is added in water. The reaction is then heated to up to 80°C. Alternatively, silver oxide may be used in place of the base, in which case the reaction may be carried out at a lower temperature. Preferably L 3 is iodo. Suitable boronate esters include lower alkyl and cyclic boronante esters. The reaction between compounds of the formulae (VA) and (IX), wherein Z is a zinc monohalide is conveniently carried out in the presence of a palladium (0) catalyst such as Pd(PPh 3 ) 4 or Pd(dba) 3 , in an inert solvent such as tetrahydrofuran, toluene or acetonitrile, in a temperature range of ambient temperature to reflux. A compound of the formula (VA) wherein Z is trimethylstannyl may be prepared by reacting a compound ofthe formula (VII) wherein Z is iodo or bromo, in an inert solvent with hexamethyldistannane in the presence of a palladium (0) catalyst, or by using methods similar to those described in Patent Application No.WO9413649. Compounds ofthe formula (VA) wherein Z is a cyclic boronate ester as in (VB): may be prepared from a compound ofthe formula (VA) wherein Z is iodo or bromo, by sequential treatment with a suitable Pd catalyst such as PdCl 2 (dppf), potassium acetate and the pinacol ester of diboron in a polar solvent such as DMSO (for example see J.Org.Chem., 1995, 60, 7508-7510). A compound ofthe formula (VA) wherein Z is a zinc monohalide may be prepared by reacting the appropriate compound ofthe formula (VA) wherein Z is iodo or bromo with a reactive form of zinc, such as zinc dust activated with zinc-copper couple (Tet. Lett. 1988, 5013) or with zinc halide and lithium naphthalenealide (J.O.C. 56, 1445, (1991)) A compound ofthe formula (IX) wherein Di is R IO CON-, S or O and L 3 is triflate may be prepared by treating a compound of the formula (IXA) with lithium diisopropylamide in an inert solvent such as THF, at a low temperature, for example -78°C, followed by N-phenyl triflamide (for example see methods described in Synthesis, 993-995 (1991)). R 4 R 5 (IXA) Alternatively, a compound ofthe formula (IX) wherein L 3 is iodo may be prepared by treating a hydrazone of a compound of the formula (IXA) with iodine in the presence of triethylamine (for example see methods detailed in Tet. Letts., 24, 1605-1608 (1983)). Compounds ofthe formula (IX) and other intermediates in which D] is NR 7 and R 7 is R l4 CH(R l3 )(CH 2 ) m - or optionally substituted: phenyl, phenyl(l-4C)alkyl, 5- or 6-membered heteroaryl, naphthyl or 5/6 or 6/6 bicyclic heteroaryl ring system may be prepared by elaboration ofthe piperidone ring from the appropriate alkyl-, aryl-, heteroaryl-, arylalkyl- or heteroarylalkyl-amine. The amine is reacted with ethyl acrylate to give the coπesponding diethylarylimino-β,β'-dipropionate, which can be cyclised under Dieckmann conditions to give the corresponding piperidone β-ketoester, followed by decarboxylation with heating in acid (see methods described in J. Chem. Soc, 51 10-51 18 (1962)). Alternatively, a compound ofthe formula (IX) or other intermediate wherein R 7 is heteroaryl may be prepared by reacting an appropriately substituted heterocycle containing a leaving group such as chloro, bromo or iodo with the appropriate 4-piperidone at an elevated temperature, in an inert solvent and optionally with an acid trapping agent. The reaction between compounds ofthe formulae (VIII) and (IX) is conveniently carried out using similar methods to those described for the reaction between compounds of the formulae (VA) and (IX), except that Z is either trialkyltin or a boronate acid or ester. The compound of the formula (VIII) may be prepared from the corresponding compound in which Z is iodo or bromo using similar methods to those described for the preparation of a compound of the formula (VA). A compound of the formula (I) or (II) wherein >Aι-B|- is ofthe formula >CHCH 2 - may be prepared from a compound of the formula (I) or (II) wherein >X-Y- is >C=CH-, by catalytic hydrogenation, using a suitable catalyst such as palladium-on-carbon in an appropriate inert or acidic solvent such as acetic acid. The dehydration of a compound of the formula (X) to give a compound of formula (I) or (II) wherein >Aj-B|- is of the formula >C=CH- may be carried out using agents such as polyphosphoric acid , trifluoroacetic acid, trifluoroacetic anhydride, p-hydroxytosyl, sulfuric acid, thionyl chloride etc., in an inert solvent such as toluene, and at elevated temperatures. Suitable protection of the group R 20 may be necessary as appropriate. A compound of the formula (X) wherein R 20 is hydroxy, may be prepared by reacting a compound ofthe formula (VI) or (VII) with a compound ofthe formula (XA): (XA) using similar methods to those described for the reaction between compounds ofthe formulae (V) and (VI) or (VII). The hydroxy group R 20 may then be converted to the amine as described in the preparation of a compound ofthe formula (III) and subsequently to the other values of R 20 . A compound ofthe formula (XA) may be prepared by deprotecting a compound of the formula (XB): (XB) wherein R 2 -R 5 and Dj are as hereinabove defined. The deprotection is conveniently carried out by refluxing it in aqueous mineral acid, such as 2N-3N hydrochloric acid. A compound ofthe formula (XB) wherein R 25 is (1 -5C)alkanoyl or arylsulfonyl may be prepared by acylating or sulfonylating a compound ofthe formula (XB) wherein R 25 is hydrogen. For example, by reacting the latter compound with the appropriate acyl halide or sulfonyl chloride in the presence of a mild base such as pyridine. A compound ofthe formula (XB) wherein R 25 is hydrogen, may be prepared by reacting the Grignard or zinc/lithium agent prepared from a compound ofthe formula (XC): (XC) wherein L 5 is iodo or bromo with a compound of the formula (IXA). Typically a Grignard or lithium organometallic species can be prepared from a compound of the formula (XC) using standard methods known in the art. The formation ofthe organometallic species is normally carried out in an inert solvent such as ether or tetrahydrofuran. These solutions are cooled to low temperature, for example -50°C to -70°C, and a solution of the compound ofthe formula (IXA) added, followed by warming to ambient temperature to complete the reaction. More preferably a zinc organometallic species is prepared from a compound ofthe formula (XC) by reacting the latter compound with activated zinc metal in an inert solvent (J.Org.Chem., 56, 1445 (1996)) or Tet. Lett., 5013 (1988) and reacting the resulting solution with a solution of the compound ofthe formula (IXA) in a temperature range of -30°C to 0°C. A compound ofthe formula (X) wherein >X-Y- is >C(OR 25 )CH 2 - may be prepared in a similar manner to a compound ofthe formula (X) wherein >X-Y- is >CHCH 2 - from an appropriate intermediate in which >X-Y- is >C(OR 25 )CH 2 -. The latter compound may be prepared by reacting the appropriate compound in which >X-Y- is >CHCH 2 - with oxyaziridine in the presence of a strong base such as hexamethyldisilazide, in an inert organic solvent such as tetrahydrofuran to give a compound in which >X-Y- is >C(OH)CH 2 - and subsequently acylating or sulfonylating if necessary. A compound ofthe formula (XI) is usually prepared as the PhS- compound, elimination occurring on oxidation ofthe PhS group to PhSO- giving a compound ofthe formula (I) or (II) wherein >X-Y- is >C=CH-. Standard oxidising agents are known in the art. One should select an oxidising agent which is capable of oxidising the -SPh group, but not other groups in the molecule. Preferred oxidising agents for this reaction include potassium peroxy monosul fate (oxone) and sodium periodate. Compounds in which >X-Y- is >C(SPh)CH 2 - are conveniently prepared by reacting the appropriate compound in which >X-Y- is >CHCH 2 - with phenyl disulfide in the presence of a base such as potassium carbonate. These procedures for converting >X-Y- from >CHCH 2 into >C=CH- are not only suitable for preparing compounds of the formula (I) or (II) but also for preparing other furanone intermediates in the preparation of compounds ofthe formula (I) or (II). Where an optically active form of compounds of the formula (VI) or (VII) is used in previous steps, reduction ofthe >X-Y- double bond will produce diastereoisomers which may be separated. Where a particular diastereoisomer is of choice, a chiral asymmetry-inducing catalyst for the reduction can be used. Compounds ofthe formulae (XII) and (XIII) or (XIV) are reacted together under standard acylation or sulfonylation conditions. For example L 4 may be chloro and the reaction may be performed in the presence of an organic base, such as pyridine or triethylamine, in a temperature range of 0°C to ambient temperature, in an inert organic solvent such as tetrahydrofuran or methylene chloride. Alternatively, the compound ofthe formula (XIII) may be replaced with acetic anhydride, in which case the reaction may be carried out in the presence of base such as sodium hydroxide under Schotten-Baumann conditions. When L 4 is hydroxy, compounds of the formulae (XII) and (XIII) may be reacted together under conditions known in the art for amino acid coupling. For example, the reaction may be carried out in an inert organic solvent in the presence of a diimide-coupling agent such as dicyclohexylcarbodiimide (DCCI). Compounds ofthe formula (I) or (II) wherein D or Dj is -NR 7 and R 7 is R l4 CH(R π )(CH 2 ) m - may be prepared by introducing the appropriate group onto the nitrogen in the compound of the formula (XII). When m is 0, the compound of the formula (XII) and R! 4 CH(R13)L 5 are conveniently reacted together under standard alkylation conditions. For example in an aprotic, solvent in the presence of an organic base such as triethylamine or pyridine, in a temperature range of 0-40°C. Suitable values for L^ include halo, mesyl and tosyl. Preferably L^ is chloro. When m is 1 , compounds ofthe formulae (XII) and R 14 CH(R 1 3 )C(=O)H may be reacted together under conditions known for the formation of an iminium salt, which can be reduced in situ. For example, iminium salt formation and reduction in situ may be carried out in a water-miscible solvent such as ethanol or tetrahydrofuran, in the presence of a reducing agent such as sodium cyanoborohydride (NaCNBH3) under acidic conditions (Synthesis 135, 1975; Org. Prep. Proceed. Int. JJ . , 201, 1979). Alternatively the iminium salt may isolated and reduced with agents such as sodium borohydride or sodium cyanoborohydride to give the desired compound of the formula (I) or (II). When m is 1 and R 13 is not hydroxy, fluoro or (l -4C)alkoxy, a compound of the formula (I) or (II) may be prepared by reacting a compound of the formula (XII) with a compound ofthe formula R!4C(R I 3 )=CH 2 under conditions suitable for the reaction known as the 'Michael addition'. For example, in an inert aprotic solvent such as tetrahydrofuran, in the presence of a base, in a temperature range of ambient temperature to 100°C. When m is 1 and R 13 is hydroxy, the compound of the formula (XII) may be reacted with an epoxy compound which is substituted on a ring carbon by R' 4 . The reaction is conveniently carried out by heating the reagents together in a temperature range of 40-100°C. A compound of the formula (I) or (II) wherein D or D] is SO or SO, may be prepared by oxidising the corresponding compound in which D or Di is S. Suitable oxidising agents for the conversion of D or Di to SO include potassium metaperiodate and peracids such as metachloroperoxybenzoic acid. Stronger oxidising agents, such as oxone may be used to convert D or Di to SO2- A compound in which R 7 is R f NHC(R B )=CHC(=O)- may be prepared by reacting the compound ofthe formula (XII) with a compound of the formula R 8 C(=O)ClI 2 COOalkyl in an inert solvent such as toluene, at elevated temperature and either in the presence of 4- dimethylaminopyridine or 4-methylbenzenesulfonic acid to give a compound in which D is of the formula R B C(=O)CH 2 C(-O)- and reacting the latter compound with a compound of the formula R f NH 2 at elevated temperature in either toluene or acetic acid. A compound in which R 7 is 2-((l-4C)alkoxycarbonyl)ethenyl may be prepared by reacting a compound ofthe formula (XII) with 2-((l-4C)alkoxycarbonyl)ethynyl at elevated temperature in either an alcohol or in an inert organic solvent. The compound in which R 7 is 2-((l-4C)alkoxycarbonyl)ethenyl may be converted to the corresponding compound in which R 7 is 2-((l-4C)alkylaminocarbonyl)ethenyl by reacting the former compound with the appropriate amine in an inert organic solvent at elevated temperature. A compound in which R 7 is ofthe formula ROC(R b )=CH(C=O)- may be prepared by reacting a compound ofthe formula (XII) with a compound ofthe formula R b C(=O)CH 2 COOalkyl using similar conditions to those described for the reaction between a compound of the formula (XII) and a compound of the formula R"C(=O)CH 2 COOalky 1 to form a compound in which R 7 is of the formula R b C(=O)CH 2 CO- and reacting the latter compound with a halide of R a , in an inert organic solvent such as THF, and in the presence of potassium carbonate. A compound in which R 7 is ofthe formula R c C(=O)C(=O)- may be prepared by reacting a compound ofthe formula (XII) with a compound ofthe formula R c C(=O)COCl in an organic solvent such as dichloromethane, in the presence of a mild base such as triethylamine and in a temperature range of 0-5°C. It is preferable to form a compound in which R c is an amino or substituted amino group by reacting a compound in which R c is an alkoxy group with the appropriate amine. A compound in which R 7 is ofthe formula R d N=C(R e )C(=O)- may be prepared from a compound in which R 7 is R c C(=O)C(=O)- or from a similar compound. The imino group may be introduced into the latter group by reacting it with the appropriate amine in an inert sorganic solvent, at elevated temperature and in the presence of an acid catalyst. The group R 7 may be introduced into earlier intermediates in which D is NH using similar method to those described above. It is also possible to convert one R 7 group into another R 7 group as a final step in the preparation of a compound ofthe formula (I) or (II). A compound ofthe formula (II) wherein R 20 is ofthe formula -N(CO 2 R 26 )CO(l- 4C)alkyl is conveniently prepared by reacting a compound of the formula (I) and (II) wherein R' or R 20 is hydroxy with an amide ofthe formula HN(CO 2 R 26 )CO(l -4C)alkyl under Mitsunobu conditions. For example, in the presence of tri-n-butylphosphine and 1.1 '- (azodicarbonyl)dipiperidine in an organic solvent such as THF, and in the temperature range 0°C - 60°C, but preferably at ambient temperature. Details of analogous Mitsunobu reactions are contained in Tsunoda et al, Tet. Letts., 34, 1639, (1993). Amides ofthe formula HN(CO 2 R 26 )CO(l-4C)alkyl may be prepared by standard procedures of organic chemistry which are within the ordinary skill of an organic chemist. When an optically active form of a compound of the formula (I) is required, it may be obtained by carrying out one of the above procedures using an optically active starting material, or by resolution of a racemic form ofthe compound or intermediate using a standard procedure. Similarly, when a pure regioisomer of a compound ofthe formula (I) is required, it may be obtained by carrying out one of the above procedures using a pure regioisomer as a starting material, or by resolution of a mixture of the regioisomers or intermediates using a standard procedure. According to a further feature ofthe invention there is provided a compound of the formula (I), or a pharmaceutically-acceptable salt thereof, for use in a method of treatment of the human or animal body by therapy. According to a further feature ofthe present invention there is provided a method for producing an antibacterial effect in a warm blooded animal, such as man, in need of such treatment, which comprises administering to said animal an effective amount of a compound of the present invention, or a pharmaceutically-acceptable salt thereof. The invention also provides a compound ofthe formula (I), or a pharmaceutically- acceptable salt thereof, for use as a medicament; and the use of a compound of the formula (I) ofthe present invention, or a pharmaceutically-acceptable salt thereof, in the manufacture of a novel medicament for use in the production of an antibacterial effect in a warm blooded animal, such as man. In order to use a compound of the formula (I) or a pharmaceutically-acceptable salt thereof for the therapeutic treatment of mammals including humans, in particular in treating infection, it is normally formulated in accordance with standard pharmaceutical practice as a pharmaceutical composition. Therefore in another aspect the present invention provides a pharmaceutical composition which comprises a compound ofthe formula (I) or a pharmaceutically-acceptable salt thereof and a pharmaceutically-acceptable diluent or carrier. The pharmaceutical compositions of this invention may be administered in standard manner for the disease condition that it is desired to treat, for example by oral, rectal or parenteral administration. For these purposes the compounds of this invention may be formulated by means known in the art into the form of, for example, tablets, capsules, aqueous or oily solutions or suspensions, (lipid) emulsions, dispersible powders, suppositories, ointments, creams, drops and sterile injectable aqueous or oily solutions or suspensions. In addition to the compounds ofthe present invention the pharmaceutical composition of this invention may also contain or be co-administered with one or more known drugs selected from other clinically useful antibacterial agents (for example β-lactams or aminoglycosides). These may include penicillins, for example oxacillin or flucloxacillin and carbapenems, for example meropenem or imipenem, to broaden the therapeutic effectiveness against methicillin-resistant staphylococci. Compounds of this invention may also contain or be co-administered with bactericidal/permeability-increasing protein product (BPI) or efflux pump inhibitors to improve activity against gram negative bacteria and bacteria resistant to antimicrobial agents. A suitable pharmaceutical composition of this invention is one suitable for oral administration in unit dosage form, for example a tablet or capsule which contains between lOOmg and lg ofthe compound of this invention. In another aspect a pharmaceutical composition of the invention is one suitable for intravenous, subcutaneous or intramuscular injection. Each patient may receive, for example, a daily intravenous, subcutaneous or intramuscular dose of 5 mgkg-1 to 20 mgkg-1 of the compound of this invention, the composition being administered 1 to 4 times per day. The intravenous, subcutaneous and intramuscular dose may be given by means of a bolus injection. Alternatively the intravenous dose may be given by continuous infusion over a period of time. Alternatively each patient will receive a daily oral dose which is approximately equivalent to the daily parenteral dose, the composition being administered 1 to 4 times per day. Antibacterial Activity The pharmaceutically-acceptable compounds ofthe present invention are useful antibacterial agents having a good spectrum of activity in vitro against standard Gram-positive organisms, which are used to screen for activity against pathogenic bacteria. Notably, the pharmaceutically-acceptable compounds ofthe present invention show activity against enterococci, pneumococci and methicillin resistant strains of S. aureus and coagulase negative staphylococci. The antibacterial spectrum and potency of a particular compound may be determined in a standard test system. The antibacterial properties of the compounds ofthe invention may also be demonstrated in vivo in conventional tests. The following results were obtained on a standard in vitro test system. The activity is described in terms of the minimum inhibitory concentration (MIC) determined by the agar-dilution technique with an inoculum size of 10 4 CFU/spot. Staphylococci were tested on agar, using an inoculum of 10 4 CFU/spot and an incubation temperature of 37°C for 24 hours - standard test conditions for the expression of methicillin resistance. Streptococci and enterococci were tested on agar supplemented with 5% defibrinated horse blood, an inoculum of IO 4 CFU/spot and an incubation temperature of 37°C in an atmosphere of 5% carbon dioxide for 48 hours - blood is required for the growth of some of the test organisms. Organism MIC (ue/mn Example 5 Staphylococcus aureus: Oxford 4.0 Novb. Res 4.0 MRQS 4.0 MRQR 8.0 Coagulase Negative Staphylococcis MS 2.0 MR 4.0 Streptococcus pyogenes C203 8.0 Enterococcus faecalis 8.0 Bacillus subtilis 4.0 Novb. Res = Novobiocin resistant MRQS = methicillin resistant quinolone sensitive MRQR = methicillin resistant quinolone resistant MR = methicillin resistant The invention is now illustrated but not limited by the following Examples in which unless otherwise stated :- i) evaporations were carried out by rotary evaporation in vacuo and work-up procedures were carried out after removal of residual solids by filtration; (ii) operations were carried out at ambient temperature, that is in the range 18-26°C and in air unless otherwise stated, or unless the skilled person would otherwise work under an inert atmosphere; (iii) column chromatography (by the flash procedure) was performed on Merck Kieselgel silica (Art. 9385) unless otherwise stated; (iv) yields are given for illustration only and are not necessarily the maximum attainable; (v) the end-products ofthe formula I generally have satisfactory microanalyses and their structures were confirmed by NMR and mass spectral techniques [proton magnetic resonance spectra were determined in DMSO-D6 unless otherwise stated using a Varian Gemini 2000 spectrometer operating at a field strength of 300 MHz, or a Bruker AM250 spectrometer operating at a field strength of 250 MHz; chemical shifts are reported in parts per million downfield from tetramethysilane as an internal standard (δ scale) and peak multiplicities are shown thus: s, singlet; d, doublet; AB or dd, doublet of doublets; t, triplet, m, multiplet; fast-atom bombardment (FAB) mass spectral data were obtained using a Platform spectrometer (supplied by Micromass) run in electrospray and, where appropriate, either positive ion data or negative ion data were collected]; (vi) intermediates were not generally fully characterised and purity was in general assessed by thin layer chromatographic, infra-red (IR), mass spectral (MS) or NMR analysis; and (vii) in which :- MPLC is medium pressure chromatography TLC is thin layer chromatography DMSO is dimethylsulfoxide CDC1 3 is deuterated chloroform MS is mass spectroscopy ESP is electrospray CI is chemical ionization DMF is N,N-dimethylformamide THF is tetrahydrofuran LDA is lithium diisopropylamide TFA is trifluoroacetic acid NMP is N-methylpyrrolidone dba is dibenzylideneacetone DME is dimethoxyethane Reference Example 1 : 4S-(2-Carboxy-2-(4-iodophenyl>ethvn-2,2-dimethyl-(l,3)-dioxolane To a stirred solution of 4-iodophenylacetic acid (20.96 g, 80mM) in THF (120ml) at -70°C under argon, was slowly added 1.85 M lithium diisopropylamide in THF (91 ml, 168 mM). There was a moderate exotherm and an intense green colour developed as the dianion formed. The solution was warmed to ambient temperature for 15 minutes then cooled back to -70°C. A solution of 4S-iodomethyl-2,2-dimethyl-(l,3)-dioxolane (J. Med. Chem. 35, 4415 (1992)) (24.2 g, 100 mM) in THF (25 ml) was added and the solution was allowed to warm to ambient temperature and stirred for 18 hours. The mixture was quenched into ice/water and adjusted to about pH4 with dilute hydrochloric acid. This was extracted with ethyl acetate and the organic phase was washed with saturated NaCI, dried (over MgSO4) and evaporated to give 4S-(2-carboxy-2-(4-iodophenyl)ethyI)-2,2-dimethyl-(l,3)-dioxolane, which was used without purification. Reference Example 2 : 5R, 3RS-5-Hvdroxymethyl-3-(4-iodophenvπdihγdrofuran-2(3H)-one 4S-(2-Carboxy-2-(4-iodophenyl)ethyl)-2,2-dimethyl-(l,3)dioxolane (Reference Example 1 ) was dissolved in THF (150 ml), and 5N aqueous hydrochloric acid (150 ml) was added. The solution was stirred for 30 hours at ambient temperature. The mixture was extracted with ethyl acetate and the organic phase was dried (MgSO4) and evaporated to give impure 5R-hydroxymethyl-3-(4-iodophenyl)dihydrofuran-2-one as an isomer mixture. Trituration with ether/ethyl acetate gave almost pure trans isomer (a sample was recrystallised from acetonitrile for NMR) (9.06 g). The remaining material was subjected to chromatography on MPLC (silica, using a 5% methanol/dichloromethane mixture as eluant) to give a pure isomer mixture after trituration with ether (8.86 g, cis:trans = 18:7). Total yield = 17.92 g (70%). Trans isomer nmr: (200 MHz. DMSO-D6) δ : 2.41 (m, partially obscured by DMSO); 3.61 (m, 2H); 4.06 (t, IH); 4.65 (6 lines, IH); 5.14 (t, IH); 7.1 1 (AB, 2H); 7.70 (AB, 2H). MS: CI + (M+NH 4 + ) = 336. Elemental Analysis: Calculated for C11 H11IO3: C, 41.5; H, 3.5. Found: C, 40.9; H, 3.4. Calculated + VA H2O: C, 40.9; H, 3.6. Cis/Trans 18:7 mixture nmr (200 MHz, DMSO-D6) δ : 2.14 (6 lines, IH (cis)); 2.55 (m, partially obscured by DMSO, cis and trans); 2.63 (m, 2H); 4.10 (t + q, IH) (cis and trans); 4.56 (m, IH (cis)) merged with 4.66 (m, IH (trans)); 5.15 (2 x t, I H); 7.13 (AB, 2H, Ar); 7.71 (AB, 2H), Ar). MS: CI + (M+NH 4 )+ = 336. Elemental Analysis: Calculated for C I J H J 1IO3: C, 41.5; H, 3.5. Found: C, 41.3; H, 3.5. Reference Example 3 : 5R. 3RS-5-Methanesulfonyloxymethyl-3-(4-iodonhenvDdihvdrofuran-2(3H)-one To a stirred mixture of 5R, 3RS-5-hydroxymethyl-3-(4-iodophenyl)dihydrofuran-2-one (Reference Example 2) (17.45 g, 54.9 mM) and triethylamine (7.39. 73 mM. 10.24 ml) in dichloromethane (200 ml) at 0°C, was slowly added methanesulfonyl chloride (7.54 g, 66 mM, 5.10 ml). The mixture was allowed to warm to ambient temperature and stirred for 1 hour. The mixture was washed with diluted hydrochloric acid, water and saturated sodium bicarbonate. It was dried over anhydrous Na2SO4 and evaporated to a crystalline mass which was triturated with ether to give 5R, 3RS-5-methanesulfon\ loxymethyl-3-(4- iodophenyl)dihydrofuran-2-one. Yield = 20.74 g (95%), cis:trans = 2:1. NMR (200 MHz. DMSO-D6) δ : 2.1 1 (m, IH (cis)); 2.68 (m, IH (cis)): trans obscured by DMSO; 3.26 (2 x S, 3H); 4.12 (m, IH); 4.48 (m, 2H); 4.32 (m, I H, (cis)); 4.46 (m, IH (trans)) partially merged ; 7.12 (AB, 2H); 7.72 (AB, 2H); MS: CI+ (M+NH 4 ) + = 414. Elemental Analysis: Calculated for C12H13IO5S: C, 36.4; H, 3.3. Found: C, 36.1 ; H, 3.3. Reference Example 4 : 5R. 3RS-5-Azidomethyl-3-(4-iodophenvDdihvdrofuran-2(3HVone A mixture of 5R, 3RS-5-methanesulfonyloxymethyl-3-(4-iodophenyl)dihydrofuran-2-one (Reference Example 3) (20.3 g, 51.3 mM) and NaN 3 (5.00g, 76 mM) in DMSO (60 ml) was stirred at 80°C for 2 hours. The mixture was quenched into water and the product was extracted with dichloromethane. The organic phase was washed with saturated NaCI, dried (over MgSO4) and evaporated to give the title product in quantitative yield as an oil. NMR: (200 MHz. DMSO-D6) δ : 2.10 (m, IH (cis)); 2.66 (m, IH (cis)); trans obscured by DMSO; 3.70 (m, 2H); 4.15 (q + t, IH); 4.72 (m, IH (cis)); merging with: 4.83 (m, IH (trans)); 7.13 (AB, 2H); 7.72 (AB, 2H). MS: CI + (M+NH 4 + ) = 361. Reference Example 5 : 5R, 3RS-5--Aminomethyl-3- ( 4-iodophenvDdih y drofuran-2(3H)-one To a stirred solution of 5R, 3RS-5-azidomethyl-3-(4-iodophenyl)dihydrofuran- 2-one (Reference Example 4) (17.7 g, 52 mM) in dimethoxyethane (DME) (100 ml) at 50°C under argon, was slowly added a solution of trimethylphosphite (7.74 g, 62.6 mM, 7.36 ml) in DME (20 ml). When effervescence had subsided, the mixture was heated under reflux for 2 hours. 6N Hydrochloric acid (1 1 ml, 66 mM) was added and reflux was continued for 18 hours. The solution was evaporated thoroughly and the residue was triturated with DME to give a thick precipitate which was filtered off, washed with DME and then with ether to give the title product. Yield (isolated) = 6.61 g (36%). NMR: (200 MHz. DMSO-D6) δ: 2.17 (m, IH (cis)); 2.35 (m, partially obscured by DMSO); 2.69 (m, IH) (cis)); 3.20 (m, 2H); 4.20 (t + q, IH); 4.77 (m. IH (cis)); 4.90, partially merged (m, IH (trans)); 7.14 (2 x d, 2H); 7.73 (2 x d, 2H); 8.33 (broad s, 3H). Cis:trans = 2: 1. MS: EI + M +=317. Elemental Analysis: Calculated for Cj 1 H12INO2: C, 37.4; H, 3.7; N, 4.0. Found: C, 37.6; H, 3.8; N, 4.0. Reference Example 6 : 5R.3RS-5"Acetamidomethyl-3-(4-iodophenvOdihvdrofuran-2(3H)-one 5R, 3RS-5-Aminomethyl-3-(4-iodophenyl)dihydrofuran-2-one (isolated solid plus filtrate residue from Reference example 5) (total 50 mM nominal) was taken into a mixture of THF (100 ml)/water (25 ml) and adjusted to pHIO with aqueous sodium hydroxide while cooling to maintain the temperature at ambient. Acetic anhydride (10.2 g, 0.1 M , 9.4 ml) was added dropwise. After complete addition, the mixture was stirred for 30 minutes at ambient temperature. The mixture was extracted with ethyl acetate and the organic phase was washed with dilute hydrochloric acid, saturated NaHCO3 and saturated NaCI. It was dried (over MgSO4) and evaporated to give a crystalline mass. The product was isolated by MPLC (Merck 9385 silica, using a mixture of 5% methanol/dichloromethane as eluant) and triturated with ether to give the title product as a pure isomer mixture (cis:trans = 2: 1 by NMR). Yield = 9.65 g (54% over 2 stages). NMR:(200 MHz. DMSO-D6) δ: 1.83 (s, 3H); 1.98 (m, IH (cis)); 2.41 (m, partially obscured by DMSO, trans); 2.60 (m, IH (cis)); 3.39 (m, 2H); 4.09 (m, IH); 4.59 (m, IH); 7.10 (AB, 2H); 7.71 (AB, 2H); 8.26 (broad m, IH). MS: CI+. (M+H) + = 360. Elemental Analysis: Calculated for C13H14INO3: C, 43.5; H, 3.9; N, 3.9 Found: C, 43.7; H. 4.0; N, 3.9. Reference Example 7 : 5R. 3RS-5-Acetamidomethyl-3-(4-trimethyltinphenvπdihvdrofuran-2(3H)-one To a stirred suspension of 5R, 3RS-5-acetamidomethyl-3-(4-iodophenyl)- dihydrofuran-2(3H)-one (Reference Example 6) (2.80g,7.89mM) in dioxan (35 ml degassed under argon) was added hexamethyldistannane (2.7 lg, 8.27 mM) followed by Pd(PPh 3 )Cl 2 (0.24g, 0.34mM).The flask was re-inerted with argon and the reaction mixture was stirred at 95-l00°C for 3 hours after which the reaction was judged complete by TLC. The solution was filtered through a pad of Celite and evaporated to a dark oil. The title product was isolated as an oil by MPLC (Merck 9385 silica, using as eluant a mixture of dichloromethane/methanol increasing in polarity from 0% to 2% methanol). Yield = l .79g (57%). NMR (200MHz. DMSO-D6) δ : 0.18 (s,9H),1.75 (s, 3H), 1.9 (m, lH(cis)), 2.3(m, lH(trans)), 2.5 (m, lH(cis)), 3.3 (m, 2H), 3.9 (m, IH), 4.45 (m, IH), 7.1 (m, 2H) 7.35 (d, 2H), 8.05 (m, IH). MS: ESP+ (M+H)=398, (M+NH 4 )=415. Reference Example 8 : 2,3-Dihvdro-4-trιfluoromethylsulfonyloxy-(6H)-pyran LDA / THF (31.5ml of 1.92M solution) was slowly added to a stirred solution of tetrahydro- 4H-pyran-4-one (5.5g) in THF (30ml) at -70°C, under argon. The mixture was stirred for 30 minutes at -70°C and then a solution of N-phenyl triflimide (21.6g) in THF (30mls) was added. The mixture was allowed to warm to ambient temperature and stirred for 18 hours. The reaction mixture was evaporated and subjected to chromatography by MPLC on Alumina (ICN, N32-63, using as eluant a mixture of ethyl acetate (5%) and iso-hexane). The product was distilled by Kugelruhr (100°C / 10mm). Remaining traces of the triflimide reagent were removed by a second MPLC (Silica, using as eluant a mixture of ethyl acetate (5%) and iso- hexane) followed by a second Kugelruhr distillation, giving the title compound as a colourless oil in 40% yield (5. Ig), which was stored at -20°C. NMR (300MHz. CDC1Λ: δ : 2.24(m,2H), 3.90(m,2H), 4.25(m,2H), 5.82(m,lH). Reference Example 9: 5R-acetamidomethyl-3-(4-trimethyltinphenyl)furan-(5H)-2-one Anhydrous potassium carbonate (5.8g, 42mM) was added to a stirred solution of Reference Example 6 (1.51g, 4.2mM) and phenyl disulfide (1.05g, 4.85mM) in THF (30ml), and the mixture was stirred vigorously at ambient temperature for 18 hours. More potassium carbonate (2.9g, 21mM) and phenyl disulfide (1.575g, 7.475mM) were added and the stirred mixture was heated under reflux for 6hours. N,N'-dimethylpropyleneurea (5ml) was added and reflux was continued for a further 18 hours after which the reaction was virtually complete (as judged by TLC). Excess 2N hydrochloric acid was carefully added and the mixture was extracted with ethyl acetate. The organic phase was washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and evaporated to give a gum. 5R-Acetamidomethyl-3-(4-iodophenyl)-3-phenylthio-dihydrofuran-(3H)-2-one was isolated by MPLC (Merck 9385 silica, 30 x 450mm column, eluted with ethyl acetate) as an amorphous foam. Yield = 1.21 g (62%). NMR (200MHz. DMSO-D61: δ : 1.80(s,3H), 2.51(m, partially obscured (DMSO)), 3.80(d of d,lH), 3.35(m, partially obscured (H2O)), 4.70(m,lH), 7.11(AB,2H), 7.31(m,5H), 6.69(AB,2H), 8.12(t,lH) MS: ESP+ (M+H) = 468. A solution of KIO4 (600mg, 2.8mM) in water (10ml) was added to a stirred solution of 5R- acetamidomethyl-3-(4-iodophenyl)-3-phenylthio-dihydrofuran-(3H)-2-one (1.19g, 2.55mM) in methanol (10ml). Some separation of starting material occurred and more methanol (20ml) was added to give solution. The mixture was stirred at ambient temperature for 18hours and then more KIO4 (600mg, 2.8mM) was added. Stirring was continued for a further 3 days after which the reaction was complete (as judged by TLC). The solvent was evaporated and the residue was partitioned between water and ethyl acetate. The organic phase was separated, washed with a saturated sodium chloride solution, dried over anhydrous Na2SO4 and evaporated to give a crystalline solid. This was triturated with ether and recrystallized from acetonitrile to give 5R-acetamidomethyl-3-(4-iodophenyl)furan-(5H)-2-one. Yield = 497mg (55%). NMR (200MHz. DMSO-D6) δ : 1.77(s,3H), 3.47(t,2H), 5.24(d of t,lH), 7.63(AB,2H), 7.82(AB,2H), 8.01(d,lH), 8.15(t, IH). MS: ESP+ (M+H)=358. Elemental analysis: Calculated for C, 3 Hι 2 INO 3 : C, 43.7; H, 3.4; N, 3.9. Found: C, 43.7; H, 3.3; N, 3.9. 5R-acetamidomethyl-3-(4-iodophenyl)furan-(5H)-2-one (1.61 g, 4.50 mmol) was suspended in dioxan (degassed by the bubbling of argon) (28 ml) and the flask purged with argon. Hexamethylditin (1.56 g, 1.00 ml, 4.77 mmol) was added followed by bis(triphenylphosphine)palladium(II) chloride (0.158 g, 0.225 mmol) and the mixture was stirred at 95 °C for 2hours. The mixture was then cooled, filtered through Celite and evaporated to an oil. This was purified by MPLC (using a mixture of MeOH/CH 2 Cl 2 increasing in polarity from 0% MeOH to 2% MeOH as eluant) to give the title stannane. Yield = 1.47 g (83%). NMR (250 MHz. CDCL): δ : 0.30 (t, 9H), 1.93 (s, 3H), 3.63 (ddd, IH), 3.75 (ddd, IH), 5.11- 5.19 (m, IH), 5.95 (bd s, IH), 7.54 (d, 2H), 7.78 (D, 2H). MS: ESP+ (M+H)=396. Reference Example 10: N-(pyrimid-2-yl)-1.2 < 5.6-tetrahvdro-4-trifluoromethyl-sulfonyloxypyridine To a stirred solution of N-(pyrimid-2-yl)-piperidin-4-one (0.177 g, 1.0 mmol) in tetrahydrofuran (5 ml) at -70 °C under argon was added LDA (1.92M in THF) (0.57 ml, 1.1 mmol). The solution was stirred for 20 minutes, then a solution of N-phenyl- bis(trifluoromethane-sulfonimide) (0.382 g, 1.07 mmol) in THF (3 ml) was slowly added. The solution was stirred overnight with warming to ambient temperature. The solution was evaporated to dryness and purified by alumina MPLC [using a mixture of 5% ethyl acetate/hexane as eluant] to afford the title product. Yield = 0.166 g (54%). NMR (250 MHz. CDC1,): δ : 2.55 (s, 2H), 4.10 (t 2H), 4.39 (m, 2H), 5.88 (s, IH), 6.55 (t, IH), 8.35 (d, 2H). MS: ESP+ (M+H)=310. Reference Example 11: 2,3-dihvdro-4-trifluoromethylsulfonyloxy-(6H)-thiopyran To a stirred solution of tetrahydrothiopyran-4-one (5.8 g, 50 mmol) in tetrahydrofuran (50 ml) at -70 °C under argon was added LDA (1.92M in THF) (26 ml, 50 mmol). The solution was stirred for 20 minutes, then a solution of N-phenyl-bis(trifluoromethane-sulfonimide) (17.85 g, 50 mmol) in THF (30 ml) was slowly added. The solution was stirred overnight with warming to ambient temperature. The solution was evaporated to dryness and purified by alumina MPLC (using a mixture of 3% Ethyl acetate/hexane as eluant) to afford the title product. Yield = 8.5g (69%). NMR (250 MHz. CDCL) δ : 2.60 (m, 2H), 2.85 (m, 2H), 3.30 (m, 2H), 5.95 (m, IH). Reference Example 12: tert-Butyldimethylsilyloxyaceryl chloride Glycolic acid (5.0 g, 66 mmol) in pyridine (65 ml) was purged with argon and then treated with ter/-butyldimethylsilyl trifluoromethanesulfonate (42 g, 36 ml, 158 mmol) at 0°C, and the mixture was stirred for 2.5 hours. The 2-phase mixture was separated and the upper phase diluted with diethyl ether. This solution was cooled to 0 °C, washed briefly with 10% hydrochloric acid, dried (MgSO4) and evaporated to the disilyl material (18 g, 97%). The disilyl material (3.48 g, 12.4 mmol) in dichloromethane (30 ml) at 0 °C was treated with DMF (6 drops) followed by oxalyl chloride (1.84 g, 1.30 ml, 14.50 mmol). After stirring for 3.5 hours, the solution was evaporated and the crude material purified by bulb-to-bulb distillation to afford the title product (60 mbar, 120 °C < T < 150 °C) (0.95 g, 37%) contaminated with /erf-butyldimethylsiloxane. NMR (250 MHz. CDCL) δ : 0.1 (s, 6H), 0.9 (s, 9H), 4.52 (s, 2H). Reference Example 13: 5R-acetamidomethyl-3-(4-(l,2.5,6-tetrahvdropyrid-4-yl|phenyl)furan-(5H)-2-one tert-Butyl-l,2,5,6-tetrahydro-4-(trifluoromethylsulfonoyloxy)pyridine-l -carboxylate (1.36 g, 4.09 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.181 g, 0.2 mmol), triphenyl arsine (0.245 g, 0.8 mmol) and lithium chloride (0.47 g, 1 1.1 mmol) were dissolved in degassed N- methyl-2-pyrrolidinone (55 ml) under argon. The stannane (Reference Example 9) (1.47 g, 3.72 mmol) in N-methyl-2-pyrrolidinone (14 ml) was added and the solution stirred at 40 °C for 75 hours. TLC then indicated complete reaction and the solution was treated with potassium fluoride (2M) (10 ml, 20 mmol) and stirred for 30 minutes. The mixture was then drowned into water (200 ml) and extracted with ethyl acetate (3 x 100 ml). The organic extracts were washed with water (2 x 100 ml), dried (MgSO 4 ) and evaporated to a residue. This was purified by MPLC (using a mixture of MeOH/CH 2 Cl 2 increasing in polarity from 0% MeOH to 3% MeOH, and then Ethyl acetate as eluant) to afford the N-BOC tetrahydropyridyl furanone (0.82 g, 53%). The N-BOC tetrahydropyridyl furanone (3.67 g, 8.9 mmol) was refluxed in TFA (12 ml) for 2 minutes, and then evaporated to a yellow gum which was triturated with diethyl ether to give the TFA salt of the title product (2.75 g, 72%) as a powder. ΝMR (250 MHz. DMSO-D6) δ : 1.73 (s, 3H), 2.69 (s, 2H), 3.37 (s, 2H), 3.45 (t. 2H), 3.80 (s, 2H), 5.23 (s, IH), 6.28 (s, IH), 7.56 (d, 2H), 7.83 (d, 2H), 7.96 (s, IH). 8.19 (t, IH), 8.90 (bd s, IH). Example 1 : 5R, 3RS-5-Acetamidomethyl-3-(4-f l-tert-butoxycarbonvI-1,2.5,6- tetrahvdropyrid-4-yl]phenyl)-dihydrofuran-2(3HVone To a stirred solution of tert-butyl- 1,2,5, 6-tetrahydro-4-(trifluoromethylsulfonyloxy)-pyridine- 1-carboxylate [Synthesis, 993 (1991)] (0.92g,2.78mM) in N-methyl pyrrolidone (15ml, degassed with helium) under argon, was added Pd 2 (dba) 3 (0.116g,0.13mM), triphenylarsine (0.159g,0.52mM) and lithium chloride (0.32g,7.59mM). After stirring for 5 minutes at ambient temperature a solution of Refence Example 7 (1.00g,2.53mM) in NMP (5ml) was added and the reaction mixture stirred at ambient temperature for 18 hours after which the reaction was complete (as judged by TLC). A l .OM solution of aqueous potassium fluoride (2.0ml) was added and the reaction mixture was stirred at ambient temperature for 30 minutes. Water was added and the product was extracted with ethyl acetate. The organic phase was separated and washed with water, saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate and evaporated to an oil. The title product was isolated as an oil by MPLC (Merck 9385 silica, using as eluant a mixture of dichloromethane/methanol increasing in polarity from 0% to 3% methanol). Yield = 0.372g (35%). The product was a pure mixture of cis(3S) and trans(3R) isomers by NMR in a 2: 1 ratio. NMR (200MHz. DMSO-D6): δ : 1.45 (s,9H),1.85 (s, 3H), 1.95 (m, lH(cis)), 2.1(m, lH(trans)), 2.45 (m, 2H), 2.6(m, lH(cis)), 3.4 (m, 2H), 3.55 (t, 2H), 4.0 (m, 2H), 4.1 (m, IH), 4.60(m, IH), 6.15 (m, IH), 7.25 (m, 2H) 7.40 (d, 2H), 8.20 (m, IH). MS: ESP+ (M+H)=415, (M+NH 4 )=432. Example 2 : 5R, 3RS-5-Acetamidomethyl-3-(4-[l,2,5,6-tetrahydropyrid-4-yl|phenyl)- dihydrofuran-2(3HVone Examplel (0.35g,0.75mM) was dissolved in an excess of TFA (3ml) and the solution stirred at ambient temperature for 1.5 hours. Ether (50ml) was added, precipitating a sticky gum. The ether was decanted off and the gum solidified on trituration with ether. Upon filtration the solid once more became a gum so the TFA salt was dissolved in methanol (20ml), evaporated and dried under high vacuum. Yield = 0.28g (87.1%). NMR (200MHz, DMSO-D6 + CD : OD^: δ : 1.88 (s, 3H), 1.92 (m, lH(cis)), 2.0 (m, lH(trans)), 2.4 (m, 2H), 2.65 (m, lH(cis)), 3.25 (m, 2H), 3.45 (t, 2H), 3.7 (m, 2H), 4.1 (m, IH), 4.60(m, IH), 6.2 (m, IH), 7.3 (m, 2H) 7.45 (d, 2H), 8.25 (m, IH), 9.55 (bd.s, IH). MS: ESP+ (M+H)=315. Example 3 : 5R, 3RS-5-Acetamidomethyl-3-(4-fl-methoxycarbonyl-l,2.5.6- tetrahvdropyrid-4-yl1phenvπdihydrofuran-2(3H)-one The trifluoroacetate salt of Example 2 (0.30g,0.70mM) and sodium bicarbonate (0.24g,2.80mM) were dissolved in a mixture of acetone and water (10ml: 5ml) at 0°C. Methyl chloroformate (59.5μl, 0.77mM) was added and the reaction allowed to rise to ambient temperature, after which the reaction was complete (as judged by TLC). Water was added and the product extracted with ethyl acetate. The organic extracts were washed with saturated aqueous sodium bicarbonate solution, saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate and evaporated to a solid. This was dried at 50°C under high vacuum to give the title product. Yield = 215.6mg (82.5%). NMR (250MHz. DMSO-D6): δ : 1.85 (s, 3H), 2.0 (m, lH(cis)), 2.2(m, lH(trans)), 2.35 (m, 2H), 2.6(m, lH(cis)), 3.4 (m, 2H), 3.55 (t, 2H), 3.65 (s, 3H), 4.05 (m. 2H), 4.1 (m. IH). 4.60(m, IH), 6.15 (m, IH), 7.25 (m, 2H) 7.40 (d, 2H), 8.18(m, IH). MS: ESP+ (M+H)=373, (M+NH 4 )=390. Analysis: Calculated for C 20 H 24 N 2 O 5 : C, 64.5; H, 6.5; N, 7.52. Found : C, 63.0; H, 6.6; N, 6.9. Calculated for 0.5 moles H 2 O : C, 63.0; H, 6.6; N, 7.3. Example 4 : 5R, 3RS-5-Acetamidomethyl-3-(4-f l-methylsulfony.-l,2,5,6- tetrahvdropγrid-4-yl1phenyl)dihvdrofuran-2(3H>-one The trifluoroacetate salt of Example 2 (0.30g,0.70mM) was dissolved in dichloromethane and triethylamine (0.48ml, 3.5mM) added. The stirred solution was cooled to 0°C and methanesulfonylchloride (59.6μl, 0.77mM) was added over 5 minutes and the reaction allowed to rise to ambient temperature. After 1 hour the reaction was complete (as judged by TLC). Water was added and the dichloromethane layer separated. The organic extracts were washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate and evaporated to a solid. The title product was isolated by MPLC (Merck 9385 silica, using as eluant a mixture of dichloromethane and methanol increasing in polarity from 0% to 2.5% methanol). This was dried at 50°C under high vacuum. Yield = 185.0mg (67.4%). NMR (300MHz. DMSO-D6): δ : 1.92 (s, 3H), 2.0 (m, lH(cis)), 2.4 (m, lH(trans)), 2.6 (m, 2H), 2.65 (m, lH(cis)), 2.9 (s, 3H), 3.25 (t, 2H), 3.4 (m, 2H (under water peak)), 3.8 (s, 2H), 4.1 (m, IH), 4.6 (m, IH), 6.15 (s, IH), 7.25 (m, 2H) 7.40 (d, 2H), 8.2(m, IH). MS: ESP+ (M+H)=393. Analysis: Calculated for C 19 H 24 N 2 O 5 S : C, 58.1; H, 6.16; N, 7.14; S, 8.17. Found : C, 55.4; H, 5.9; N, 6.7; S, 6.8. Calculated for 1.0 mole H 2 O : C, 55.6; H, 6.4; N, 6.8; S, 7.9. Example 5 : 5R.3RS-5-Acetamidomethyl-3-(4-[l-hvdroxyacetyl-1.2,5,6-tetrahydropyrid- 4-yl|phenyD dihvdrofuran-2(3H)-one The trifluoroacetate salt of Example 2 (0.30g,0.70mM) was dissolved in DMF (30ml) and triethylamine (0.48ml, 3.5mM) added. To this stirred solution was added 4- dimethylaminopyridine (8.5mg,0.07mM), glycolic acid (79.9mg, 1.05mM) and l-ethyl-3-(3- dimethylaminopropyl)carbodiimide (EDC) (0.20 lg, 1.05mM). The reaction mixture was stirred under argon for 5 hours after which hardly any reaction had occurred (as determined by HPLC). A further 0.75 equivalents each of glycolic acid and EDC were added and the reaction stirred for a further 36 hours. After this time HPLC indicated 30% starting material remaining and the reaction mixture was worked-up by adding water and extracting with ethyl acetate. The organic extracts were washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate and evaporated to a gum. The title product was isolated by MPLC (Merck 9385 silica, using as eluant acetone, followed by a mixture of dichloromethane and methanol (5%)) as a solid. This was dried at 40°C under high vacuum. Yield = 36.0mg (13.8%). NMR (400MHz, DMSO-D61: δ : 1.85 (s, 3H), 2.1 (m, lH(cis)), 2.4 (m, lH(trans)), 2.6 (m, 2H), 2.65 (m, lH(cis)), 3.25 (t, 2H), 3.50&3.70 (2χt, IH), 4.1 (m, 5H), 4.55 (d, IH) 4.65 (m, IH), 6.15 (d, IH), 7.25 (m, 2H) 7.40 (d, 2H), 8.2(m, IH). MS: ESP+ (M+H)=373. Analysis: Calculated for C20H24NA . C, 64.5; H, 6.5; N, 7.52. Found : C, 61.8; H, 6.6; N, 6.5. Calculated for 1.0 mole H 2 O : C, 61.5; H, 6.7; N, 7.2. Example 6: 5R-acetamidomethyl-3-(4-(2.3-dihvdro-6H-pyran-4-yl)phenyl)- furan-(5H)-2-one The triflate (Reference Example 8) (0.58 g, 2.50 mmol), tris(dibenzylideneacetone)- dipalladium(O) (0.144 g, 0.125 mmol), triphenyl arsine (0.153 g, 0.50 mmol) and lithium chloride (0.286 g, 6.75 mmol) were dissolved in degassed NMP (33 ml). The stannane (Reference Example 9) (0.89 g, 2.25 mmol) in NMP (9 ml) was added and the solution stirred at 40 °C for 17 hours. TLC indicated incomplete reaction and more triflate (0.155 g, 0.67 mmol) was added. After a further 20 hours, the solution was treated with aqueous potassium fluoride solution (2M) (6.50 ml, 12.50 mmol) and stirred for 20 minutes. The mixture was then drowned into water (150 ml) and extracted with ethyl acetate (3 x 80 ml). The organic extracts were washed with water (2 x 100 ml), dried (MgSO 4 ) and evaporated to a residue. This was purified by MPLC (using as eluant a mixture of MeOH/CH 2 Cl 2 increasing in polarity from 0% MeOH to 3% MeOH) to afford product which was triturated with diethyl ether to give the title product (0.301 g, 43%) as a powder. NMR (250 MHz. CDCU: δ : 1.94 (s, 3H), 2.53 (bd s, 2H), 3.64 (dt, IH), 3.76 (dt, I H), 3.94 (t, 2H), 4.34 (d, 2H), 5.19 (s, IH), 6.06 (bd t, IH), 6.20 (bd s, IH), 7.43 (d, 2H), 7.55 (s, IH), 7.80 (d, 2H). MS: ESP+ (M+H)=314. Example 7: 5R-acetamidomethyl-3-(4-(l-fpyrimid-2-yll-1.2,5,6-tetrahvdropyrid-4-yl} phenyl)-furan-(5H)-2-one The triflate (Reference Example 10) (0.344 g, 1.11 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.051 g, 0.056 mmol), triphenyl arsine (0.068 g, 0.222 mmol) and lithium chloride 90.127 g, 3.00 mmol) were dissolved in degassed N- methyl-2-pyrrolidinone (ΝMP) (10 ml). The stannane (Reference Example 9) (0.399 g, 1.0 mmol) in ΝMP (4 ml) was added and the solution was stirred at 40 °C for 60 hours. The mixture was then drowned into water (150 ml) and extracted with ethyl acetate (3 x 80 ml). Aqueous potassium fluoride solution (2M) (2.78 ml, 5.55 mmol) was added to the combined organic extracts and stirring continued for 20 minutes. The organic layer was washed with water (2 x 100 ml), dried (MgSO 4 ) and evaporated to a residue. This was purified by MPLC (using as eluant a mixture of MeOH/CH 2 Cl 2 increasing in polarity from 0% MeOH to 4% MeOH) to afford a product which was triturated with diethyl ether to give the title product (0.053 g, 14%) as a powder. ΝMR (250 MHz. CDCM: δ :1.94 (s, 3H), 2.60-2.68 (m, 2H), 3.62 (ddd, IH), 3.77 (ddd, IH). 4.09 (t, 2H), 4.42 (d, IH), 4.47 (d, IH), 5.14 (m, IH), 5.75-5.84 (m, IH), 6.25-6.80 (m, IH), 6.51 (t, IH), 7.46 (d, 2H), 7.53 (d, IH), 7.82 (d, 2H), 8.35 (d, 2H). MSl ESP+ (M+H)=391. Example 8: 5R-acetamidomethvI-3-(4-(2,3-dihvdro-6H-thiopyran-4-yl)phenyl)- furan-(5H)-2-one The triflate (Reference Example 11) ( 2.0g, 8.10 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.375 g, 0.41 mmol), triphenyl arsine (0.50 g, 1.64 mmol) and lithium chloride (1.04 g, 25.00 mmol) were dissolved in degassed N-methyI-2- pyrrolidinone (ΝMP) (20 ml). The stannane (Reference Example 9) ( 1.60 g, 4.10 mmol) in ΝMP (4 ml) was added and the solution was stirred at 40 °C for 48 hours. The solution was treated with aqueous potassium fluoride solution (2M) (8.00 ml, 16.00 mmol) and stirred for 35 minutes. The mixture was then partitioned between water (100 ml) and ethyl acetate (100 ml) and the organic layer washed with water (2 x 100 ml), filtered through Celite, dried (MgSO 4 ) and evaporated to a residue. This was purified by MPLC (using ethyl acetate as eluant) to afford a product which was triturated with diethyl ether to give the title product (0.23 g, 17%) as a powder. NMR (250 MHz. CDCM: δ : 1.94 (s, 3H), 2.66-2.74 (m, 2H), 2.90 (dd, 2H), 3.23-3.39 (m, 2H), 3.62 (ddd, IH), 3.76 (ddd, IH), 5.1 1-5.20 (m, IH), 5.80-5.90 (m, IH), 6.23 (t, IH), 7.38 (d, 2H), 7.53 (d, 1 H), 7.79 (d, 2H). Example 9 : 5R-acetamidomethyl-3-(4- ( 1 -hyd roxyacetyl- 1 ,2,5,6-tetrahydropyrid-4- yllphenyD-furan-(5H)-2-one To a stirred solution of the TFA salt (Reference Example 13) (0.249 g, 0.58 mmol) in acetone:water (2:1) (12 ml) at 0 °C was added sodium hydrogen carbonate (0.196 g, 2.30 mmol) and the acid chloride (Reference Example 12) (0.362 g, 1.74 mmol). After 1.5 hours more acid chloride (0.184 g, 0.88 mmol) was added and stirring continued for 19 hours at ambient temperature. TLC indicated remaining amine and more acid chloride (0.120 g, 0.28 mmol) was added and stirring continued for a further 4 hours. The solution was diluted with water (15 ml), extracted with ethyl acetate (3 x 30 ml), dried and evaporated. The residue was purified by MPLC (using as eluant a mixture of MeOH/CH 2 Cl 2 increasing in polarity from 0% MeOH to 4% MeOH) to afford the title product (0.065 g, 30%) as a solid. NMR (250 MHz. CDCU): δ : 1.95 (s, 3H), 2.59 (s, 2H), 3.45-4.05 (m, 6H), 4.23 (d, 2H), 4.30 (d, IH), 5.20 (s, IH), 6.10 (d, IH), 6.47 (s, IH), 7.37-7.50 (m, 2H), 7.59 (s, I H), 7.80 (d, 2H). MS: ESP+ (M+H)=371. Example 10: 5R-acetamidomethyl-3-(4-(l-benzyloxyaceryl-l,2,5,6-tetrahvdropyrid-4- yUphenyl)-furan-(5H)-2-one To a stirred solution ofthe TFA salt (Reference Example 13) (0.213 g, 0.50 mmol) in acetone:water (2:1) (10 ml) at 0 °C was added sodium hydrogen carbonate (0.168 g, 2.00 mmol) and benzyloxyacetyl chloride (0.185 g, 0.158 ml, 1.74 mmol). After 4 hours more acid chloride (0.040 ml) was added and stirring continued for 19 hours. The solution was diluted with water (10 ml), extracted with ethyl acetate (2 x 20 ml), dried and evaporated to a solid. This was purified by MPLC (using as eluant a mixture of MeOH/CH 2 Cl 2 increasing in polarity from 0% MeOH to 3% MeOH) and then triturated with diethyl ether to afford the title product (0.068 g, 30%) as a solid. NMR (250 MHz. CDCU: δ : 1.91 (s, 3H), 2.55 (bd s, 2H), 3.60-3.78 (m, 3H), 3.83 (t. IH), 4.18 (bd s, IH), 4.24 (d, 3H), 4.60 (s, 2H), 5.18 (bd s, IH), 6.09 (bd d, IH), 6.22 (bd s, IH), 7.25-7.42 (m, 7H), 7.57 (d, IH), 7.80 (d, 2H). MS: ESP+ (M+H)=461. Example 11: 5R-acetamidomethyl-3-(4-(l-acetoxyaceryl-l,2,5,6-tetrahvdropyrid-4- yl) phenvDfu ran-(5H)-2-one To a stirred solution of the TFA salt (Reference Example 13) (0.201 g, 0.47 mmol) in acetone:water (2:1) (10 ml) at 0 °C was added sodium hydrogen carbonate (0.159 g, 1.89 mmol) and acetoxyacetyl chloride (0.129 g, 0.101 ml, 0.94 mmol). After 4 hours more acetoxyacetyl chloride (0.025 ml) was added and stirring continued for 0.25 hours. The solution was extracted with ethyl acetate (2 x 20 ml), dried and evaporated to a yellow oil. This was purified by MPLC (using as eluant a mixture of MeOH/CH 2 Cl 2 increasing in polarity from 0% MeOH to 3% MeOH) and then triturated with diethyl ether to afford the title product (0.073 g, 38%) as a crystalline solid. NMR (250 MHz. CDCL): δ : 1.93 (s, 3H), 2.20 (s, 3H), 2.60 (bd s, 2H), 3.58-3.90 (m, 4H). 4.10 (bd s, IH), 4.25 (bd s, IH), 4.79 (d, 2H). 5.18 (bd s, I H), 6.02-6.18 (m, 2H). 7.40 (d. 2H), 7.57 (d, lH), 7.80 (d, 2H). MS: ESP+ (M+H)=413. Example 12 The following illustrate representative pharmaceutical dosage forms containing the compound of formula I, or a pharmaceutically-acceptable salt thereof (hereafter compound X), for therapeutic or prophylactic use in humans: (a) Tablet I mg/tablet Compound X 100 Lactose Ph. Eur 179 Croscarmellose sodium 12 Polyvinylpyrrolidone 6 Magnesium stearate 3 (b) Tablet II mg/tablet Compound X 50 Lactose Ph.Eur 229 Croscarmellose sodium 12 Polyvinylpyrrolidone 6 Magnesium stearate 3 (c) Tablet III mg/tablet Compound X 1 Lactose Ph.Eur 92 Croscarmellose sodium 4 Polyvinylpyrrolidone 2 Magnesium stearate 1 (d) Capsule mg/capsule Compound X 10 Lactose Ph.Eur 389 Croscarmellose sodium 100 Magnesium stearate 1 (e) Injection I (50 mg/ml) Compound X 5.0% w/v Isotonic aqueous solution to 100% Buffers, pharmaceutically-acceptable cosolvents such as polyethylene glycol, polypropylene glycol, glycerol or ethanol or complexing agents such as hydroxy-propyl β cyclodextrin may be used to aid formulation. Note The above formulations may be obtained by conventional procedures well known in the pharmaceutical art. The tablets (a)-(c) may be enteric coated by conventional means, for example to provide a coating of cellulose acetate phthalate.

Claims: CLAIMS 1. A compound ofthe formula (I) :- (I) wherein: R 1 is hydroxy or of the formula -NHC(=O)(l-4C)alkyl or -NHS(O) n (l-4C)alkyl wherein n is 0, 1 or 2; R' and R J are independently hydrogen or fluoro; W and R 3 are independently hydrogen or methyl >A-B- is of the formula >C=CH- , >CHCH 2 - , or >C(OH)CH 2 - (> represents two single bonds); D is O, S, SO, SO 2 or NR 7 ; R 7 is hydrogen, cyano, 2-((l-4C)alkoxycarbonyl)ethenyl, 2-cyanoethenyl, 2-cyano-2-(( 1 -4C)alkyl)ethenyl, 2-((l-4C)alkylaminocarbonyl)ethenyl, AR (as defined hereinbelow) or a tetrazole ring system (optionally mono-substituted in the 1- or 2- position of the tetrazole ring) wherein the tetrazole ring system is joined to the nitrogen in NR 7 by a ring carbon atom; or R 7 is of the formula R IO CO- , R l0 SO 2 - or R I0 CS- wherein R 10 is AR (as defined hereinbelow), cyclopentyl or cyclohexyl (wherein the last two- mentioned cycloalkyl rings are optionally mono- or disubstituted by substituents independently selected from (l-4C)alkyl (including geminal disubstitution), hydroxy, ( 1 -4C)alkoxy, (1 -4C)alkylthio, acetamido, (1 -4C)alkanoyl, cyano and trifluoromethyl), ( 1 -4C)alkoxycarbonyl, hydrogen, amino, trifluoromethyl, (l-4C)alkylamino, di(( 1 -4C)alkyl)amino, 2,3-dihydro-5-oxothiazolo-[3,2-A]pyrimidin-6-yl, 2-(2-furyl)ethenyl, 2-(2-thienyl)ethenyl, 2-phenylethenyl (wherein the phenyl substituent is optionally substituted by up to three substituents independently selected from (l-4C)alkoxy, halo and cyano), 3,4- dihydropyran-2-yl, coumal-5-yl, 5-methoxy-4-oxopyran-2-yl, N-acetylpyrrolidin-2-yl, 5-oxo- tetrahydrofuran-2-yl, benzopyranone or ( 1 - 10C)alkyl [wherein (1-1 OQalkyl is optionally substituted by hydroxy, cyano, halo, (1-lOQalkoxy, benzyloxy, trifluoromethyl, ( 1 -4C)alkoxy-( 1 -4C)alkoxy, ( 1 -4C)alkoxy-( 1 -4C)aIkoxy-( 1 -4C)alkoxy , ( 1 -6C)alkanoyl, (l-4C)alkoxycarbonyl, amino, (l-4C)alkylamino, di((l-4C)alkyl)amino, (1- 6C)alkanoylamino, (l-4C)aIkoxycarbonylamino, N-(l-4C)alkyl-N-(2-6C)alkanoylamino, (1- 4C)alkylS(O) p NH-, (l-4C)alkylS(O) p ((l-4C)alkyl)NH-, fluoro(l-4C)aIkylS(O) p NH-, fluoro(l-4C)alkylS(O) p ((l-4C)alkyl)NH-, phosphono, (l -4C)alkoxy(hydroxy)phosphoryl, di-(l-4C)alkoxyphosphoryl, (l-4C)alkylS(O) q - , phenylS(O) q - (wherein the phenyl group is optionally substituted by up to three substituents independently selected from (l-4C)alkoxy, halo and cyano), or CY (as defined hereinbelow), wherein p is 1 or 2 and q is 0, 1 or 2] ; or R' υ is ofthe formula R"C(O)O(l-6C)alkyl wherein R" is an optionally substituted 5- or 6-membered heteroaryl, optionally substituted phenyl, (l-4C)alkylamino, benzyloxy-(l-4C)alkyl or optionally substituted (1 -1 OQalkyl; 10 12 12 or R is ofthe formula R O- wherein R is optionally substituted (1-όQalkyl; or R 7 is of the formula R a OC(R b )=CH(C=O)-, R c C(=O)C(=O)-, R d N=C(R e )C(=O)- or R f NHC(R g )=CHC(=O)- wherein R a is (1 -OQalkyl, R b is hydrogen or (1 -OQalkyl, or R a and R b together form a (3-4C)alkylene chain, R c is hydrogen, (l-6C)alkyl, hydroxy(l-6C)alkyl, (l-6C)alkoxy(l-6C)alkyl, amino, (l-4C)alkylamino, di-(l-4C)alkylamino, (l-6C)alkoxy, (l-6C)alkoxy(l-6C)alkoxy, hydroxy(2-6C)alkoxy, (l-4C)alkylamino(2-6C)alkoxy, di-(l-4C)alkylamino(2-6C)alkoxy, R is ( 1 -6C)alkyl, hydroxy or ( 1 -6C)alkoxy , R e is hydrogen or ( 1 -6C)alky 1, R is hydrogen, (l-6C)alkyl, optionally substituted phenyl or an optionally substituted 5- or 6-membered heteroaryl and R 6 is hydrogen or (l-6C)alkyl; or R 7 is ofthe formula R 14 CH(R 13 ) (CH 2 ) m - wherein m is 0 or 1 , R 13 is fluoro, cyano, (l-4C)alkoxy, (l-4C)alkylsulfonyl, ( 1 -4C)alkoxycarbonyl or hydroxy, (provided that when m is 0, R 13 is not fluoro or hydroxy) and R 14 is hydrogen or (l-4C)alkyl; wherein AR is optionally substituted phenyl, optionally substituted phenyl(l -4C)alkyl, optionally substituted 5- or 6-membered heteroaryl, optionally substituted naphthyl or an optionally substituted 5/6 or 6/6 bicyclic heteroaryl ring system, in which the bicyclic heteroaryl ring systems may be linked via an atom in either of the rings comprising the bicyclic system, and wherein the mono- and bicyclic heteroaryl ring systems are linked via a ring carbon atom; wherein CY is a 4-, 5- or 6-membered cycloalkyl ring, a 5- or 6-membered cycloalkenyl ring, naphthoxy, thiophen-2-yl, indol-1-yl, indol-3-yl, pyrimidin-2-ylthio, 1 ,4-bcnzodioxan-6-yl, sulfolan-3-yl, pyridin-2-yl; wherein any of the afore-mentioned ring systems in CY may be optionally substituted by up to three substituents independently selected from halo, (l-4C)alkyl (including geminal disubstitution when CY is a cycloalkyl or cycloalkenyl ring), acyl, oxo and nitro-(l-4C)alkyl; >X- Y- is of the formula >C=CH- or >CHCH 2 -; and pharmaceutically-acceptable salts thereof. 2. A compound of the formula (I) as claimed in claim 1 wherein: R 1 is hydroxy or of the formula -NHC(=O)(l-4C)alkyl or -NHS(O)„(l-4C)alkyl wherein n is 0, 1 or 2; R 2 and R 3 are independently hydrogen or fluoro; R 4 and R 5 are independently hydrogen or methyl; >A-B- is ofthe formula >C=CH-, >CHCH 2 or >C(OH)CH 2 - (> represents two single bonds); D is O, S, SO, SO 2 or -NR 7 ; wherein R 7 is hydrogen, 2-((l-4C)alkoxycarbonyl)ethenyl, 2-((l-4C)alkylaminocarbonyl)ethenyl or optionally substituted: phenyl. phenyl(l-4C)alkyl, 5- or 6-membered heteroaryl, naphthyl or 5/6 or 6/6 bicyclic heteroaryl ring system wherein the heteroaryl ring systems are joined to the nitrogen in NR 7 by a ring carbon atom; or R 7 is of the formula R'°CO- or R IO SO 2 - wherein R'° is amino, (l-4C)alkylamino, di((l-4C)alkyl)amino, or (l-6C)alkyl [wherein (1 -6C)alkyl is optionally substituted by hydroxy, cyano, ( 1 -6C)alkoxy . benzy loxy , ( 1 -6C) alkanoyl, amino, (l-4C)alkylamino, di-(l-4C) alkylamino, (l -6C)alkanoylamino, N-(l-4C)alkyl-N-(l-6C)alkanoylamino, (l-4C)alkylS(O) p NH-, (1 -4C)alkylS(O) p ((l-4C)alkyl)NH-, phosphono, (l-4C)alkoxy(hydroxy)phosphoryl, di-(l-4C)alkoxyphosphoryl, or (l-4C)alkylS(O)p wherein p is 1 or 2]; or R 10 is ofthe formula R"C(O)O(l-6C)alkyl wherein R" is optionally substituted 5- or 6- membered heteroaryl, optionally substituted phenyl or optionally substituted (l-6C)alkyl; or R 10 is ofthe formula R l2 O- wherein R 12 is optionally substituted (l-6C)alkyl; or R 7 is ofthe formula ROC(R b )=CH(C=O)-, R c C(=O)C(=O)-, R d N=C(R e )C(=O)- or R f NHC(R g )=CHC(=O)- wherein R a is (1 -OQalkyl, R b is hydrogen or (1 -OQalkyl or R a and R b together form a (3-4C)alkylene chain, R c is hydrogen, (l-6C)alkyl, hydroxy(l-6C)alkyl, (1 -6C)alkoxy( 1 -6C)alkyl, amino, ( 1 -4C)alkylamino, di-( 1 -4C)alkylamino, ( 1 -6C) alkoxy, ( 1 - 6C)alkoxy(l-6C)alkoxy, hydroxy(2-6C)alkoxy, (l-4C)alkylamino(2-6C)alkoxy, di-(l - 4C)alkylamino(2-6C)alkoxy, R d is (l-6C)alkyl, hydroxy or (l -6C)alkoxy, R e is hydrogen or (l-6C)alkyl, R f is (l-6C)alkyl, phenyl or a 5- or 6-membered heteroaryl and R 8 is hydrogen or (1 -OQalkyl; or R 7 is of the formula R I4 CH(R 13 ) (CH 2 ) m - wherein m is 0 or 1, R n is fluoro, cyano, (l-4C)alkoxy, (l-4C)alkylsulfonyl, (l-4C)alkoxycarbonyl or hydroxy; (provided that when m is 0, R π is not fluoro or hydroxy) and R H is hydrogen or (l-4Qalkyl; >X-Y- is of the formula >C=CH- or >CHCH 2 -; and pharmaceutically-acceptable salts thereof. 3. A compound ofthe formula (I) as claimed in claims 1 and 2 wherein: R 1 is of the formula -NHC(=O)(l-4C)alkyl; R 2 and R 3 are independently hydrogen or fluoro; R J and R 5 are independently hydrogen or methyl; >A-B- is ofthe formula >C=CH- or >CHCH 2 (> represents two single bonds); D is O, S or -NR 7 ; wherein R 7 is hydrogen, 2-((l-4C)alkoxycarbonyl)ethenyl, 2-((l-4C)alkylaminocarbonyl)ethenyl or optionally substituted: phenyl, phenyl(l -4C)alkyl, 5- or 6-membered heteroaryl, naphthyl or 5/6 or 6/6 bicyclic heteroaryl ring system wherein the heteroaryl ring systems are joined to the nitrogen in NR 7 by a ring carbon atom; or R 7 is ofthe formula R IO CO- or R IO SO 2 - ; wherein R ,0 is amino, (l -4C)alkylamino, di((l-4C)alkyl)amino, or (l-όC)alkyl [wherein (1 -6C)alkyl is optionally substituted by hydroxy, cyano, (l-6C)alkoxy, benzy loxy, (1 -6C) alkanoyl, amino, (l-4C)alkylamino, di-(l-4C) alkylamino, (l-6C)alkanoylamino, N-(l-4C)alkyl-N-(l-6C)alkanoylamino, (l-4C)alkylS(O) p NH-, (1 -4C)alkylS(O) p ((l-4C)alkyl)NH-, phosphono, (l-4C)alkoxy(hydroxy)phosphoryl, di-(l-4C)alkoxyphosphoryl, or (l-4C)alkylS(O)p wherein p is 1 or 2]; or R 10 is ofthe formula R n C(O)O(l-6C)alkyl wherein R" is optionally substituted 5- or 6- membered heteroaryl, optionally substituted phenyl or optionally substituted (l-6C)alkyl; or R 10 is ofthe formula R 12 O- wherein R 12 is optionally substituted (l-6C)alkyl; or R 7 is of the formula ROC(R b )=CH(C=O)-, R c C(=O)C(=O)-, R d N=C(R c )C(=O)- or R f NHC(R K )=CHC(=O)- wherein R a is ( 1 -6C)alkyl, R b is hydrogen or ( 1 -6C)alky 1 or R a and R b together form a (3-4C)alkylene chain, R c is hydrogen, (1 -OQalkyl, hydroxy(l -6C)alkyl. (l-6C)alkoxy(l-6C)alkyl. amino, (l -4C)alkylamino. di-(l-4C)alkylamino. (1 -6C) alkoxy, ( 1 -6C)alkoxy( 1 -6C)alkoxy, hydroxy(2-6C)alkoxy, ( 1 -4C)alkylamino(2-6C)alkoxy, di-(l-4C)alkylamino(2-6C)alkoxy, R d is (l-6C)alkyl, hydroxy or (l-6C)alkoxy. R e is hydrogen or (1 -6C)alkyl, R r is (l-6C)alkyl, phenyl or a 5- or 6-membered heteroaryl and R g is hydrogen or (1 -OQalkyl; or R 7 is ofthe formula R 14 CH(R π ) (CH 2 ), n - wherein m is 0 or 1, R IJ is fluoro. cyano, (l-4C)alkoxy, (l-4C)alkylsulfonyl. (l -4C)alkoxycarbonyl or hydroxy; (provided that when m is 0, R π is not fluoro or hydroxy) and R 14 is hydrogen or (l-4C)alkyl; >X-Y- is of the formula >C=CH- or >CHCH r : and pharmaceutically-acceptable salts thereof. 4. A compound of the formula (I) as claimed in claims 1 to 3 wherein R' is acetamido; >X-Y- is of the formula >C=CH- ; both R 2 and R 3 are hydrogen; >A-B- is of the formula >C=CH-; R 4 and R 5 are hydrogen; D is O, S or ofthe formula -NR 7 ; R 7 is hydrogen or of the formula R ,0 CO-; R 10 is hydroxy(l -4C)alkyl, (l-4C)alkanoyloxy(l-4C)alkyl or (l-5C)alkoxy; and pharmaceutically-acceptable salts thereof. 5. A compound of the formula (I) as claimed in claims 1 to 3 wherein R' is acetamido; >X-Y- is ofthe formula >C=CH- ; one of R 2 and R 3 is hydrogen and the other is fluoro; >A- B- is of the formula >C=CH-; R 4 and R 5 are hydrogen; D is O, S or of the formula -NR 7 ; R 7 is hydrogen or of the formula R'°CO-; R'° is hydroxy( 1 -4Qalkyl, (l-4C)alkanoyloxy(l-4C)alkyl or (l-5C)alkoxy; and pharmaceutically-acceptable salts thereof. 6. A compound ofthe formula (I), or a pharmaceutically-acceptable salt thereof, as claimed in claims 1 to 4 selected from :- 5R-acetamidomethyl-3-(4-[l -hydroxyacetyl- 1,2,5, 6-tetrahydropyrid-4-yl]phenyl)-furan- 2(5H)-one and 5R-acetamidomethyl-3-(4-[2,3-dihydropyran-4-yl]phenyl)furan-2(5H)-one. 7. A process for the preparation of a compound ofthe formula (I) as claimed in claims 1 to 6 which comprises :- (a) the deprotection of a compound of formula (II): (H) (b) the modification of a substituent in or the introduction of a substituent into another compound ofthe formula (I) or (II); (c) when R 20 is ofthe formula -NHS(0)„(l-4C)alkyl, wherein n is lor 2, the oxidation of a compound ofthe formula (I) or (II) wherein n is 0 or, when n is 2 the oxidation of a compound of the formula (I) or (II) wherein n is 1 ; (d) when R 20 is ofthe formula -NHC(=O)(l-4C)aIkyl or -NHS(O)„(l-4C)alkyl, and >A r B,- is >C=C-, >CHCH 2 -, or protected >C(OH)CH 2 - the reaction of a compound of the formula (III) with a compound of formula (IV): (HI) (IV) (e) when R 20 is hydroxy and >X-Y- is >CHCH 2 -: the reaction of a compound ofthe formula (V) wherein >Ai-Bj- is >C=CH-, >CHCH 2 - or protected >C(OH)CII 2 _ with a compound of formula (VI): (V) (VI) or the reaction of a compound of the formula (V) with a compound ofthe formula (VII): (VII) (f) when >A]-B|- is >C=CH-, the reaction of a compound of the formula (VIII) with a compound ofthe formula (IX): (g) when >A]-Bι- is >CHCH 2 - and >X-Y- is >CHCH 2 - , the catalytic hydrogenation of a compound of the formula (I) or (II) wherein >A r Bι- is >C=CH- and >X-Y is >CHCH 2 -; (h) when >Aι-B]- is >C=CH- and >X-Y- is >CHCH 2 -, the elimination ofthe elements of water, or HOCOR 23 , or HOSO 2 R 24 from a compound ofthe formula (X): (X) (i) when >A,-B|- is >C=CH- and >X-Y- is >CH=CH-, the elimination ofthe elements of water, HOCOR 23 or HOSO 2 R 24 from a compound ofthe formula (X) wherein >X-Y- is >C(OR 25 )-CH 2 -; (j) when >A,-B r is >C=CH- and >X-Y- is >C=CH- the elimination of PhSOH from a compound of the formula (XI); (XI) (k) when D is NR 7 and R 7 is R 10 CO- , R IO S(O)„- or R ,0 CS- , the reaction of a compound of the formula (XII) wherein >A r Bι- is >C=CH-, >CHCII 2 . or protected >C(OH)CH 2 -, with a compound of the formula (XIII) , (XIV) or (XV) respectively wherein n is 2: R 10 COL 4 R 10 SO n L 4a R 10 CSL 4b (XII) (XIII) (XIV) (XV) (1) when R 20 is ofthe formula -N(CO 2 R 26 )CO(l-4C)alkyl; from a compound of the formula (I) and (II) wherein R 1 or R 20 is hydroxy; wherein R 2 -R 5 and >X-Y- are as hereinabove defined; >A ! -B]- is >A-B- or protected >C(OH)CH 2 - and D] is D in which functional groups are optionally protected; R 19 is -C(=O)(l -4C)alkyl or -S(O)„(l-4C)alkyl; R 20 is R' or protected R 1 ; R 21 is hydrogen or (l-6C)alkyl; R 22 is a protecting group; R 23 is (l-4C)alkyl; R 24 is an optionally substituted phenyl group; R 25 is hydrogen, (l-5C)alkanoyl or arylsulfonyl; R 26 is (l-4C)alkyl or benzyl; n is 0, 1 or 2 unless otherwise stated; L 1 , L 2 and L 4a are leaving groups, L 4 t> is a leaving group (for example (1 -4C)alkoxy), L 3 is an iodo or triflate leaving group, L 4 is hydroxy or a leaving group and Z is a trialkyltin residue, a boronate acid or ester residue or a zinc monohalide and thereafter if necessary any protecting groups are removed and a pharmaceutically-acceptable salt formed; and when an optically active form of a compound of the formula (I) is required, it may be obtained by carrying out one of the above procedures using an optically active starting material, or by resolution of a racemic form ofthe compound or intermediate using a standard procedure; and when a pure regioisomer of a compound of the formula (I) is required, it may be obtained by carrying out one of the above procedures using a pure regioisomer as a starting material, or by resolution of a mixture ofthe regioisomers or intermediates using a standard procedure. 8. A pharmaceutical composition which comprises a compound of the formula (I) or a pharmaceutically-acceptable salt thereof, as claimed in claims 1 to 6 and a pharmaceutically- acceptable diluent or carrier. 9. The use of a compound ofthe formula (I) or a pharmaceutically-acceptable salt thereof, as claimed in claims 1 to 6 in the manufacture of a novel medicament for use in the production of an antibacterial effect in a warm blooded animal, such as man.

Inventors: GRAVESTOCK MICHAEL BARRY, GRAVESTOCK, MICHAEL, BARRY
Applicants: GRAVESTOCK MICHAEL BARRY, ZENECA LTD, GRAVESTOCK, MICHAEL, BARRY, ZENECA LIMITED
Application year: 1997
Main classification: C07D405
IPC codes: A61K31, A61P31, C07D405, C07D407, C07D409