Apparatus for and a method of diffusion-sensitized magnetic resonance imaging

Abstract: Within a selected slice or slab, diffusion sensitising gradients ( 54, 56 ) and read gradients ( 66, 68 ) are induced along each of a pair of orthogonal axes (G x , G y ). The motion sensitising gradient pulses sensitise excited magnetic resonance to diffusion in a preselected diffusion direction (D) which is orthogonal to a selected read gradient direction. The diffusion sensitising gradients are rotated by sin(+π/2) and cos(+π/2) and the read gradients are rotated by sin and cos to generate a plurality of angularly displaced data lines. The diffusion sensitivity direction remains perpendicular to the read direction in each of the angularly displaced data lines. The phase of each data line is determined ( 90 ) and shifted ( 94 ) to compensate for linear translations. The data values within each data line are shifted ( 86 ) to centre the peak amplitude of the data line at a preselected position to compensate for higher order motion. The set of angularly incremented data lines are reconstructed ( 96 ) into an image representation ( 98 ). In one embodiment, a plurality of the images are generated, each from data lines with their peak value shifted to a location which is offset by a fraction of a sample relative to the data lines which constructed the other images. Corresponding patches of these corresponding images are examined ( 110 ) for phase. Based on the examination, the one of the corresponding patches with the best image quality is transferred to a final image memory ( 114 ). In this manner, the final image is made up of the best patches of a plurality of corresponding images.

Description: The present invention relates to magnetic resonance imaging. The invention finds particular application in conjunction with images emphasising diffusion and will be described with particular reference thereto. Diffusion in biological systems yields various direct and indirect information. Water which diffuses in biological systems over distances on the order of 10 microns in a time of 10-100 milliseconds are imageable with magnetic resonance imaging techniques. In order to image diffusion, larger than normal gradients are applied, such that the diffusion provides a significant change in the magnetic resonance signal. In general, the more sensitive the image to diffusion, the larger the diffusion sensitising gradient. Some diffusion images are interpreted by comparing two or more images. Other diffusion images are diffusion direction sensitive such that a single image can be analysed to generate meaningful diffusion information. One of the problems with diffusion imaging is that the large gradients which encode the diffusion also induce a large sensitivity to patient motion. In living humans and animals, this high sensitivity to motion causes artifacts. For example, diffusion images of human medical patients routinely exhibit ghosting and other motion artifacts of such a magnitude that they can make the technique unreliable and unusable. In one diffusion imaging technique, bipolar gradient waveforms are placed in an imaging sequence after the initial RF excitation and before the spatially encoded readout. When a spin echo is used, the diffusion sensitising gradient typically has components placed on opposite sides of the 180° RF pulse. Because the spin system has its polarity inverted by the 180° pulse, the components have a common polarity and are often referred to as "balanced" instead of bipolar. In other imaging sequences without a refocusing pulse, the components of the diffusion sensitising gradient have opposite polarities. One technique for minimising the effects of bulk motion is to minimise the motion itself with mechanical constraints or by sedating or anesthetising the patient. The effects of motion can also be reduced by synchronising data collection with periodic physiological activity, such as cardiac gating, respiratory gating, and the like. Constraining motion has several drawbacks. First, restricting the patient is often uncomfortable or physiologically unpleasant to the patient. The discomfort in some instances actually causes the patient to move more than if unrestrained. Gating requires additional complexity, and additional preparation of the patient. Moreover, gating restricts the choices of the sequence repeat time, slows data collection, and generally reduces the temporal efficiency of the acquisition. Sedation and anesthesia is not only inconvenient. but can be risky, expensive, and require additional professional personnel to be on hand for the exam. Moreover, these techniques are unlikely to help when the motions are not voluntary or periodic, such as swallowing or peristalsis. Another method for reducing motion artifacts is to use very rapid readouts, particularly echo-planar readouts. In echo-planar imaging, there may be phase errors induced by the motion upon the readout signal, but these phase errors are typically uniform across the entire signal collection and across the entire image. One of the problems with echo-planar imaging is that the stringent gradient requirements can typically only be met by expensive, special purpose hardware. The high speed of echo-planar imaging also limits resolution. Echo-planar images are also subject to other artifacts such as spatial distortions from susceptibility changes. Another approach is to acquire the signal with MR spatial imaging techniques which are intrinsically less sensitive to phase errors induced by bulk motion, for example, line scanning. Line scanning, however, has an intrinsic low signal-to-noise ratio. For medically useful images, an acceptable signal-to-noise ratio can often only be obtained at low spatial resolutions. Moreover, line scanning techniques are comparatively time inefficient, especially if several images of parallel slice positions are desired. Other spatial encoding methods have a reduced dependency on signal phase or other parameters which may be corrupted by the combination of diffusion gradients and bulk motion. Projection reconstruction, for example, can be formulated to have less corruption from these errors than similar two-dimensional Fourier transform phase-encoding techniques. However, projection reconstruction as performed previously in the prior art only corrects for some bulk motion such as linear displacements, but not for other motions such as rotations, expanding and contracting movement, twisting movement, or the like. In MRM 29 (1993) 835-838, use of a projection reconstruction method to decrease motion sensitivity in diffusion-weighted MRI is disclosed. The diffusion gradient is applied along a fixed direction. Data acquisition might be rendered more temporally efficient with other readout methods, such as interleaved multi-shot echo-planar imaging. Because such scans are acquired in a substantially shorter time period, there is less time for patient motion. Patient cooperation tends to be improved for shorter imaging intervals. Moreover, rapid readout techniques may provide sufficient time for averaging to smooth artifacts. Of course, faster scans only reduce motion somewhat. Signal averaging may cause the appearance of ghosts to become more uniform and less highly peaked, but the intensity of the images is still incorrect. Errors which are smoother or which exhibit less structure are more difficult to recognise as errors. Faster scanning often compromises the signal-to-noise ratio, image contrast, or introduces unusually large dependencies upon motion. Prior art techniques are available which use more sophisticated gradient waveforms to reduce or suppress sensitivity to certain forms of bulk motion such as velocity, acceleration, pulsatility, or the like. Some of these techniques may retain their sensitivity to diffusion. Unfortunately, motion compensated gradient waveforms have less diffusion sensitivity for a given gradient strength and echo time than would be obtained by other techniques. Moreover, the higher complexity and larger total area of the motion compensated diffusion weighted gradients may cause other technical difficulties such as increased eddy currents relative to the imaging gradients or diffusion gradients. Another approach is to measure or estimate the patient motion and correct the acquired data for the measured motion. For example, in some techniques, additional readouts or navigator echoes are added to the other acquired data for the sole purpose of providing positional correction information. However, navigator echoes reduce scanning efficiency and may be complicated or very inconvenient to implement. They can only estimate and correct for some kinds of motion. In general, the more modes of motion to be monitored, the more navigator echoes that are required. Further, the time at which the navigator echoes are acquired may be different and may exhibit different magnetic resonance signal evolution than the main signal, hence may give inaccurate estimates of the effect of motion on the main signal. Stronger, shorter diffusion gradients tend to have less motion sensitivity, or at least less motion sensitivity relative to the amount of diffusion sensitivity. However, large, short gradients are difficult to apply. Expensive hardware would be required. Further, such large, short gradients may introduce problems such as biomedical side effects on the patient and are generally not an available option on existing magnetic resonance systems. When the primary degrading motion is in regions of the image other than the region of interest, the artifacts may be reduced with a suppressing signal to those regions. For example. spatial pre-saturation or FLAIR may be utilised. Of course, such techniques are not helpful when there is significant motion-related error from the tissue of interest. In accordance with one aspect of the present invention, a method of magnetic resonance imaging is provided. Magnetic resonance is excited and then read out along a plurality of read out directions to generate a plurality of data lines. The read out data lines are rotated about the origin such that the data lines are collected at each of a plurality of angularly incremented, rotated orientations about an origin. The data lines are reconstructed into an image representation. Prior to collecting each data line, balanced diffusion sensitising gradient pulses are applied to sensitise for diffusive motion in a direction orthogonal to the data line direction. In this manner, sensitivity to diffusion is perpendicular to the data line and rotates around the origin with the data line orientations. The technique of the present application provides for a practical collection of MR image data with significant sensitivity to diffusion, but which are relatively insensitive to patient motion. In accordance with another more limited aspect of the present invention, a location of a peak magnitude of each read out data line is determined. The data of the data line is shifted such that the peak magnitude location is shifted to a preselected location within each data line. In accordance with another more limited aspect of the present invention, a phase of each data line is determined at a preselected location along the data line. The phase of each data line is adjusted in accordance with a difference between the determined phase and a preselected phase. In accordance with another aspect of the present invention, a magnetic resonance imaging system is provided. A magnet generates a temporally constant magnetic field through an examination region. A radio frequency pulse controller and transmitter induces dipoles in the examination region to resonance such that radio frequency resonance signals are generated. Magnetic field gradient coils and a gradient magnetic field controller generate slice or slab select, read, and diffusion sensitising gradient pulses across the examination region. A receiver receives and demodulates radio frequency magnetic signals read out during the read gradients to produce a series of data lines. A reconstruction processor reconstructs the data lines into an image representation. An image memory stores the reconstructed image representation. A means is provided for applying the diffusion sensitising gradient in a direction perpendicular to the read out direction of the data lines and for rotating the read and diffusion sensitising gradients together such that the diffusion sensitivity and the read out directions are angularly incremented around an origin. The invention will now be described, by way of example, with reference to the accompanying drawings, in which: Figure 1 is a diagrammatic illustration of a magnetic resonance imaging system in accordance with the present invention; Figure 2 illustrates an exemplary spin echo imaging sequence in accordance with the present invention; Figure 3 illustrates the filling of k-space and the vector direction of maximum diffusion sensitivity; Figure 4 illustrates a rotational movement induced shift of the data line in k-space; Figure 5 illustrates an exemplary fast spin echo sequence; Figures 6A, 6B, and 6C illustrate the collection of data lines in rotated rectangular swaths; Figure 7 illustrates three-dimensional diffusion sensitisation; and, Figure 8 illustrates an exemplary spin echo sequence with three-dimensional diffusion sensitivity. With reference to Figure 1, a main magnetic field control 10 controls superconducting or resistive magnets 12 such that a substantially uniform, temporally constant magnetic field is created along a z-axis through an examination region 14 . A magnetic resonance echo means applies a series of radio frequency (RF) and magnetic field gradient pulses to invert or excite magnetic spins, induce magnetic resonance, refocus magnetic resonance, manipulate magnetic resonance, spatially and otherwise encode the magnetic resonance, to saturate spins, and the like to generate magnetic resonance imaging and spectroscopy sequences. More specifically, gradient pulse amplifiers 20 apply current pulses to selected ones or pairs of whole body gradient coils 22 to create magnetic field gradients along x, y, and z-axes of the examination region 14 . A digital radio frequency transmitter 24 transmits radio frequency pulses or pulse packets to a whole body RF coil 26 to transmit RF pulses into the examination region. A typical radio frequency pulse is composed of a packet of immediately contiguous pulse segments of short duration which taken together with each other and any applied gradients achieve a selected magnetic resonance manipulation. The RF pulses are used to saturate, excite resonance, invert magnetisation, refocus resonance, or manipulate resonance in selected portions of the examination region. For whole body applications, the resonance signals are commonly picked up by the whole body RF coil 26 . For generating images of limited regions of the subject, local coils are commonly placed contiguous to the selected region. For example, an insertable head coil 30 is inserted surrounding a selected brain region at the isocentre of the bore. The insertable head coil preferably includes local gradient coils 32 which receive current pulses from the gradient amplifiers 20 to create magnetic field gradients along x, y, and z-axes in the examination region within the head coil. A local radio frequency coil 34 is used to excite magnetic resonance and receive magnetic resonance signals emanating from the patient's head. Alternatively, a receive-only local radio frequency coil can be used to receive resonance signals induced by body-coil RF transmissions. An RF screen 36 blocks the RF signals from the RF head coil from inducing eddy currents in the gradient coils and the surrounding structures. The resultant radio frequency signals are picked-up by the whole body RF coil 26 , the local RF coil 34 , or other specialised RF coils and demodulated by a receiver 38 , preferably a digital receiver. A sequence control circuit 40 controls the gradient pulse amplifiers 20 and the transmitter 24 to generate any of a plurality of multiple echo sequences, such as echo-planar imaging, echo-volume imaging, gradient and spin echo imaging, fast spin echo imaging, and the like. For the selected sequence, the receiver 38 receives a plurality of data lines in rapid succession following each RF excitation pulse. An analog-to-digital converter 42 converts each data line to a digital format. The analog-to-digital converter can be disposed between the radio frequency receiving coil and the receiver for digital receivers or downstream from an analog receiver. With continuing reference to Figure 1 and further reference to Figure 2, a rotation, back-projection imaging sequence is implemented by the sequence control 40 in which the data acquisition line is rotated in steps about the centre of k-space. More specifically, an RF excitation pulse 50 , a 90° pulse in the illustrated spin-echo embodiment, is applied concurrently with a slice select gradient 52 . The first portions 54a, 56a of a pair of balanced diffusion sensitising gradients 54, 56 are applied along gradient axes G x , G y which are orthogonal to each other and the slice select axis. An RF refocusing pulse 60 is applied concurrently with another slice select pulse 62 . Second portions 54b, 56b of the balanced diffusion sensitising pulses 54, 56 are then applied. Due to the 180° inversion pulse, the corresponding first and second pulse portions along each axis effectively have the opposite polarity from each other. Of course, the bipolar diffusion sensitising pulses are analogously applied with non-spin-echo sequences as well. The resonance excitation and inversion pulses induce a magnetic resonance echo 64 . A pair of read gradient pulses 66, 68 are applied concurrently with the echo. With particular reference to Figure 3, the sequence control 40 includes an angle indexing means 70 which scales the read gradients 66, 68 on read gradient axes G x and G y as cos and sin, respectively, in each repetition. In this manner, the direction along which the data is collected rotates about an origin in k-space. The cos and sin scaling of course, causes one of the read gradients to shrink as the other grows, with the magnitude of the combined vector gradient G x X +G y Y remaining substantially constant. The angle indexing means 70 also indexes the balanced diffusion gradients such that the direction of maximum diffusion sensitivity is perpendicular to the direction of data collection in k-space, i.e., the first diffusion sensitising gradient pulse 54 and the second balanced diffusion sensitising pulse 56 are also scaled, but as cos(+π/2) and sin(+π/2), respectively. In this manner, both the direction of the data line in k-space and the direction of maximum diffusion sensitivity of the sequence are rotated in increments to remain orthogonal to each other. With reference again to Figure 1 and further reference to Figure 4, with the large balanced diffusion sensitising gradients and no movement, the data line tends to have a peak 80 at the centre of k-space where it crosses the zero phase-encode data line. Perfectly linear movement, (i.e., rigid body translational displacements) adds a constant phase error e -iα to the entire data line. Rotational patient movement, particularly in-plane rotations, cause the data line to shift along the data collection trajectory of k-space. With reference again to Figure 1, as each digital data line is received from the receiver 38 and analog-to-digital converter 42 , it is passed to a peak detector 82 . The peak detector determines the peak of each data line. A centring system 84 determines the difference between the location of the determined peak of the data line and a reference centre. The reference centre point is selected for mathematical convenience in the reconstruction process. Alternately, the reference data line may be a data line collected without the diffusion gradients. A data shifting processor 86 shifts each data line by the determined difference or offset. Of course, because the data is digital and sampled, the offset is typically measured and shifted in amounts corresponding to one sample. Shifts of the data more accurate than a discrete sample incorporate interpolation methods. A fractional offset adder 88 optionally adds further offset to the shift as is explained in more detail below. A phase measurement circuit 90 measures the phase at a preselected location along the data line, preferably at the peak. A phase shift determining circuit 92 determines the difference between the measured phase and the phase of the reference data line. A complex multiplier 94 makes the determined phase shift to the centred data line. A filtered back-projection reconstruction processor 96 reconstructs a set of data lines into an image representation of the selected slice which is stored in one plane of an image memory 98 . Optionally, other reconstruction techniques may be utilised, operating either directly on the rotated data lines or a rebinning circuit 100 can be used to rearrange the points along the radially arranged data lines into sets of parallel data lines. The rebinned parallel data lines are reconstructed 102 using conventional reconstruction techniques for parallel data lines, such as a two-dimensional Fourier transform reconstruction technique. A correction for susceptibility errors is preferably made, especially if only 180° of projections are acquired. The position of the RF spin echo is shifted in time relative to the time when the acquired data echo forms, i.e., the centre of k-space. Any data which is off resonance exhibits a phase shift which is proportional to the frequency shift error. In the preferred embodiment, the data for a single slice is reconstructed with no fractional offset added by the fractional offset circuit 88 and again with a plurality of other fraction of a pixel offsets and the resultant slice image stored in another plane of the image memory 98 . That is, an image is generated with each data line peak centred at the reference centre. Another image is generated with the data line peak shifted to the central reference sample but offset from the reference centre by the equivalent of a fraction of a sample, e.g., 0.3. Other images which have their centres spanning the centre sample in increments, e.g., an image at 0 offset, an image at +0.3 offset, an image at -0.3 offset, at +0.6, at -0.6, at +0.9, and at -0.9. Each reconstructed image is divided into the same plurality of segments or patches. A patch examining means 110 examines the corresponding patch in each of the plurality of images of the same slice to determine which is in the best focus or otherwise has the best image quality. In the preferred embodiment, the focus checking circuit 110 reads the phase at a preselected, preferably centre pixel of each region or patch. The phase map is used to determine which of the corrected offset images is most accurate to use at any given pixel location. Optionally, phase shift at several pixels can be measured and averaged. Once the circuit 110 determines which patch has the least phase error or is for other reasons the best quality diagnostic image, a data loading circuit 112 loads the data from that patch into a blended image memory 114 . Preferably, a smoothing circuit 116 smooths the interface between adjacent patches. For example, each patch can overlap adjacent patches by a preselected number of pixels. The patch edge smoothing circuit performs a weighted averaging of the overlapping pixels. Various alternate embodiments immediately suggest themselves. For example, rather than rotating the read gradient by 180°, the read gradient can be swept a full 360° to average the data. With reference to Figure 5, a plurality of additional RF refocusing pulses 120 , and read gradients 122, 124 are applied following each excitation for shorter data acquisition times. Each time the read gradients are applied, they are rotated or indexed with the sin/cos relationship discussed above. With this fast spin-echo type sequence, multiple, angularly offset data lines are generated in each repetition. With reference to Figures 6A, 6B, and 6C, the data lines collected following each excitation are alternately parallel to each other to generate a small set of parallel data lines. The read gradients of Figure 5 are scaled linearly following each refocusing pulse. In this manner, a plurality of sets of angularly displaced parallel data lines are generated. These data lines are regridded and reconstructed as described above. As another alternative, rather than using a spin-echo, the data can also be collected after a stimulated echo, particularly where long echo times are desired to gain significant diffusion weighting. This technique can also be used in conjunction with fat saturation. The signal from fat is significantly off-resonance from water. The use of fat saturation inhibits the artifacts which the off-resonance fat tissue tends to cause during projection reconstruction. Of course, this technique is also applicable to multi-slice imaging, as well as slab or volume imaging. In slab and volume imaging a phase-encode gradient is applied along the slice select gradient direction to provide encoding along the third dimension. Unlike most diffusion imaging techniques in which the diffusion vector is in the same direction for all data lines, the present technique rotates the direction of the vector of maximum diffusion sensitivity. In this manner, the technique images diffusion in multiple directions. With reference to Figure 7, the diffusion gradient direction D has a rotating component D r in the plane of the data line, and an orthogonal component D s in the slice select direction. With reference to Figure 8, the component in the slice select direction, achieved by adding a diffusion sensitising pulse 130 along the slice select axes, encodes the diffusion along a third direction. Because diffusion sensitivity is provided now with components both in plane perpendicular to the data line and components perpendicular to the slice, the diffusion gradient sweeps out a cone. Preferably, the strength of the diffusion gradient along the slice select direction is 1/√2 of the strength of the diffusion gradient in the in plane direction to provide an approximately equal diffusion weighting along all three principal axes on average. In this manner, independent diffusion information is generated as would normally be generated by calculating a tensor trace image from three independently acquired diffusion images, each primarily sensitive to diffusion along a different one of three orthogonal axes. Many biological structures are known a priori to have a structure which orients diffusion substantially along a single direction. For example, some biological structures function as a series of parallel tubes with significant diffusion axially and reduced diffusion across their barriers. In such tissue, it is preferred that the slice select direction be selected such that it runs parallel to the main diffusion orientation of the fibers. One image parallel to the tissue orientation and one image with diffusion sensitivity perpendicular to the tissue orientation are acquired to produce a pair of images which fully describe the anisotropy of the diffusion. In another alternate embodiment, two images are acquired, one with the diffusion rotating in plane and the other sensitised along the slice select direction. By combining these two images, the resultant image is substantially free of directional dependence. Of course, an appropriate weighting between the two images should be made. As another alternative, each of the collected data lines is converted to a projection, preferably by a Fourier transform. Such a magnitude-only data line needs no phase correction or even positioning. These magnitude projections are then reconstructed, preferably by convolution back-projection into the resultant image. Numerous other trajectories through k-space are also contemplated. The series of trajectories may move through k-space in two or three dimensions in any of a multiplicity of simple or elaborate schemes, with the diffusion vector perpendicular to the k-space trajectory. The technique may also be used with inherently 3D data that is collected with all projections. The diffusion direction is varied such that it is perpendicular to each readout direction. The described embodiments thus provide rotating diffusion MR imaging with reduced motion artifacts. A primary advantage of the described embodiments resides in their improved immunity to motion, including rotational motion, acceleration, and other higher order motions. Another advantage is that they can be performed with conventional magnetic resonance imaging equipment without the addition of special hardware. Another advantage resides in their reduced dependence on the directionality of the diffusion. Other advantages include a good signal-to-noise ratio, high resolution, and efficient scan time.

Claims: A method of magnetic resonance imaging in which magnetic resonance is excited and read out along a plurality of read out directions to generate a plurality of data lines, the read out directions being rotated about an origin such that the data lines are collected at each of a plurality of angularly incremented, rotated orientations around the origin, the data lines being reconstructed into an image representation, wherein, prior to collecting each data line, diffusion sensitising gradient pulses are applied to sensitise for diffusion flow in a direction orthogonal to the data line direction such that sensitivity to diffusion during the collection of the data line is perpendicular to the data line and rotates around the origin with the data line orientations. A method as claimed in Claim 1, wherein after collecting each data line, a location of a peak magnitude of the read out data line is determined; and the data line is shifted such that the location of peak magnitude is at a preselected location within the data line. A method as claimed in Claim 2, wherein a plurality of sets of data lines are collected, for each set of data lines; in the step of shifting the location of peak magnitude to a preselected location, the data lines of each set are shifted to a different preselected location. which different preselected locations vary from each other by a distance corresponding to a fraction of a sample, the plurality of data lines of each set being reconstructed into separate images. A method as claimed in Claim 3, wherein each of a plurality of corresponding patches of the separate images are examined to determine which of the corresponding patches has a preferred image quality; and splicing the patches with the preferred image quality together to derive a resultant image. A method as claimed in any one of Claims 1 to 4, wherein a slice select gradient is applied concurrently with the excitation pulse, the slice select gradient being applied parallel to a slice select direction such that resonance is excited in a selected slice; the diffusion sensitising gradient pulses being applied along (i) the slice select axis, (ii) a first axis perpendicular to the slice select axis, and (iii) along a second axis perpendicular to the slice select and first axes; and in the reading out step, read gradients are applied along the first and second axes, such that the direction of diffusion sensitisation rotates along a cone. A method as claimed in any one of Claims 1 to 5, including the steps of determining a phase of each data line at a preselected location along the data line; determining a difference between the determined phase and a preselected phase; adjusting the phase of each data value of the data line by the determined difference. Apparatus for magnetic resonance imaging, which includes a magnet (12) for generating a temporally constant magnetic field through an examination region, a radio frequency pulse controller and a transmitter (24, 40) for inducing dipoles in the examination region to resonance such that radio frequency resonance signals are generated, magnetic field gradient coils (22) and a gradient magnetic field controller (20, 40) for generating slice or slab select, read, and diffusion sensitising gradient pulses across the examination region, a receiver (38) for receiving and demodulating radio frequency magnetic signals read out during the read gradients to produce a series of data lines, a reconstruction processor (96, 102) for reconstructing the data lines into an image representation, and an image memory (98) for storing the reconstructed image representation, including means (70, 40) arranged for applying the diffusion sensitising gradient in a direction perpendicular to the read out direction of the data lines and for rotating the read and diffusion sensitising gradients together such that the diffusion sensitivity and the read out direction of the data lines which are reconstructed are angularly incremented about an origin. Apparatus as claimed in Claim 7, further including a peak detector (82) for detecting a location of maximum amplitude of each data line; data line centring means (84, 86) connected with the peak detector for shifting data values along the data line such that the detected peak value is at a preselected location along the data line; and, fractional offset means (88) for further shifting the location of the detected peak value by a distance corresponding to a selected fraction of a sample. Apparatus as claimed in Claim 8, further including means (90) for measuring a difference between a phase of data at a preselected location along the data line relative to the detected peak and determining a phase shift between the measured phase and a preselected phase; and means (92) for phase shifting the phase of each data line by the determined phase shift. Apparatus as claimed in any one of Claims 8 or 9, wherein the image memory has a plurality of memory planes, each memory plane storing a reconstructed image with a different fractional offset applied by the fractional offset means and further including means (110) for examining at least one preselected data value in each of a preselected plurality of corresponding patches of the plurality of images to determine a phase at the selected pixel and for selecting based on the determined phase one of the corresponding patches for inclusion in a final image; and means (112, 116) for merging each of the selected patches into a final image memory (114) to produce the final image.

Inventors: DANNELS WAYNE R, LIU HAIYING, XU YANSUN, DANNELS, WAYNE R., LIU, HAIYING, XU, YANSUN
Applicants: KONINKL PHILIPS ELECTRONICS NV, KONINKLIJKE PHILIPS ELECTRONICS N.V.
Application year: 1997
Main classification: G01R33
IPC codes: G01R33, A61B5