POLYCYSTIC KIDNEY DISEASE GENE

Abstract: The present invention involves isolated nucleic acid encoding human PKD1, and sequences derived therefrom. The invention also encompasses vectors comprising these nucleic acids, host cells transformed with the vectors, and methods for producing PKD1 protein or fragments thereof. In another aspect, the invention involves isolated oligonucleotides that hybridize only to the authentic expressed PKD1 gene, and not to PKD1 homologues. In yet another aspect, the invention involves isolated mutant PKD1 genes, and their cDNA cognates. Further provided are isolated oligonucleotides that discriminate between normal and mutant versions of the PKD1 gene. Methods and compositions for treating APKD or disease conditions having the characteristics of APKD are also provided.

Description: POLYCYSTIC KIDNEY DISEASE GENE This application is a continuation-in-part of U.S. patent application Serial No. 08/381,520, filed January 31, 1995. FIELD OF THE INVENTION The present invention pertains to the diagnosis and treatment of polycystic kidney disease in humans, using DNA sequences derived from the human PKDl gene and the protein or proteins encoded by that gene. BACKGROUND OF THE INVENTION Autosomal dominant polycystic kidney disease (APKD) , also called adult-onset polycystic kidney disease, is one of the most common hereditary disorders in humans, affecting approximately one individual in a thousand. The prevalence in the United States is greater than 500,000, with 6,000 to 7,000 new cases detected yearly (Striker et al., Am. J. Nephrol . , 6:161-164, 1986; Iglesias et al. , Am. J. Kid. Dis. , 2:630-639, 1983). The disease is considered to be a systemic disorder, characterized by cyst formation in the ductal organs such as kidney, liver, and pancreas, as well as by gastrointestinal, cardiovascular, and musculoskeletal abnormalities, including colonic diverticulitis, berry aneurysms, hernias, and mitral valve prolapse (Gabow et al., Adv. Nephrol . , 18:19-32, 1989; Gabow, New Eng. J. Med. , 329:332-342, 1993). The most prevalent and obvious symptom of APKD, however, is the formation of kidney cysts, which result in grossly enlarged kidneys and a decrease in renal- concentrating ability. Hypertension and endocrine abnormalities are also common in APKD patients, appearing even before symptoms of renal insufficiency. In approximately half of APKD patients, the disease progresses to end-stage renal disease; accordingly, APKD is responsible for 4-8% of the renal dialysis and transplantation cases in the United States and Europe ( Proc . European Dialysis and Transplant Assn. , Robinson and Hawkins, eds., 17:20, 1981). Thus, there is a need in the art for diagnostic and therapeutic tools to reduce the incidence and severity of this disease. APKD exhibits a transmission pattern typical of autosomal dominant inheritance, i.e., each offspring of an affected individual has a 50% chance of inheriting the causative gene. Linkage studies indicated that a causative gene is present on the short arm of chromosome 16, near the α-globin cluster; this locus was designated PKDl (Reeders et al., Nature, 317:542, 1985). Though other PKD-associated genes exist, such as, for example, PKD2, PKDl defects appear to cause APKD in about 85-90% of affected families (Parfrey et al., New Eng. J. Med. , 323:1085-1090, 1990; Peters et al. , Contrijb. Nephrol . , 97:128-139, 1992). The PKDl gene has been localized to chromosomal position 16pl3.3. Using extensive linkage analysis, in conjunction with the identification of new markers and restriction enzyme analysis, the gene has been further localized to an interval of approximately 700 kb between the markers ATPL (ATP6C) and CMM65 (D16S84) . The region is rich in CpG islands that are thought to flank transcribed sequences, and it has been estimated that this interval contains at least 20 genes. The precise location of the PKDl gene was pinpointed by the finding of a PKD family whose affected members carry a translocation that disrupts a 14 kb RNA transcript associated with this region, as reported in the European PKD Consortium (EPKDC) , Cell , 77:881, 1994, describing approximately 5631 bp of DNA sequence corresponding to the 3 ' end of the putative PKDl cDNA sequence. Notwithstanding knowledge of the partial PKDl 3 ' cDNA sequence, several significant impediments stand in the way of determining the complete sequence of the PKDl gene. For the most part, these impediments arise from the complex organization of the PKDl locus. One serious obstacle is that sequences related to the PKDl transcript are duplicated at least three times on chromosome 16 proximal to the PKDl locus, forming PKDl homologues. Another obstacle is that the PKDl genomic interval also contains repeat elements that are present in other genomic regions. Both of these types of sequence duplications interfere with "chromosome walking" techniques that are widely used for identification of genomic DNA. This is because these techniques rely on hybridization to identify clones containing overlapping fragments of genomic DNA; thus, there is a high likelihood of "walking" into clones derived from PKDl homologues instead of clones derived from the authentic PKDl gene. In a similar manner, the PKDl duplications and chromosome 16-specific repeats also interfere with the unambiguous determination of a complete cDNA sequence that encodes the PKDl protein. Thus, there is a need in the art for genomic and cDNA sequences corresponding to the authentic PKDl gene. This includes identification of segments of these sequences that are unique to the expressed PKDl and not are present in the duplicated homologous sequences also present on chromosome 16. SUMMARY OF THE INVENTION The present invention involves an isolated normal human PKDl gene having the sequence set forth in Figure 1, sequences derived therefrom such as the sequence set forth in Figure 2, an isolated nucleic acid having the PKDl cDNA sequence set forth in Figure 3, and sequences derived therefrom. The PKDl gene is a genomic DNA sequence whose altered, defective, or non-functional expression leads to adult-onset polycystic kidney disease. The invention also encompasses DNA vectors comprising these nucleic acids, cells transformed with the vectors, and methods for producing PKDl protein or fragments thereof. In another aspect, the invention involves isolated oligonucleotides that hybridize only to the authentic expressed PKDl gene, and not to PKDl homologues. In yet another aspect, the invention involves isolated mutant PKDl genes, and their cDNA cognates, which contain alterations in nucleotide sequence relative to the normal PKDl gene, and whose presence in one or more copies in the genome of a human individual is associated with adult- onset polycystic kidney disease. In still another aspect, the invention involves isolated oligonucleotides that discriminate between normal and mutant versions of the PKDl gene. In still another aspect, the invention involves methods for identifying a human subject carrying a mutant PKDl gene in a human subject, comprising: a) obtaining a sample of biological material from the subject, and b) detecting the presence of the mutant gene or its protein product. In still another aspect, the invention involves methods and compositions for treating APKD or disease conditions having the characteristics of APKD. Such methods encompass administering an isolated human PKDl gene, or fragments of the gene, under conditions that result in expression of therapeutically effective amounts of all, or part of, the PKDl protein. The invention also encompasses compositions for treating APKD that comprise all or part of the PKDl DNA of Figures 1, 2 and 3, or the PKDl protein encoded by the DNA of Figures 1, 2 or 3. BRIEF DESCRIPTION OF THE DRAWINGS Figure IA shows the DNA sequence of the human PKDl locus between chromosomal markers ATPL (ATP6C) and D16S84. (SEQ ID NO:l) . Figure IB shows the DNA sequence of 53,526 bases comprising the normal human PKDl gene. (SEQ ID NO:2) . Figure 2 shows a partial DNA sequence of 894 bases within the 5' region of normal human PKDl DNA. (SEQ ID NO:3) Figure 3 shows the full-length sequence of normal human PKDl cDNA and corresponding amino acid sequence. (SEQ ID NOS:4-5) . Figure 4A shows a comparison of the DNA sequence of the 5 ' region of DNAs derived from the authentic PKDl gene (SEQ ID N0:19) and PKDl homologues (SEQ ID N0:18) . A 29-base pair gap must be introduced into the sequence of the authentic gene to align the two sequences. In addition, the authentic PKDl and the PKDl homologue differ at position 418 of this figure. Figure 4B shows the DNA sequence of an oligonucleotide that can be used to discriminate between the authentic PKDl sequence and PKDl homologues. The star denotes a polymerization-blocking modification. (SEQ ID NO:10). Figure 5 shows the region of chromosome 16 containing the PKDl locus. The upper panel shows Notl restriction sites, as well as previously identified genetic markers in this region. The bottom panel shows PI clones covering this region. Figure 6 shows the restriction map of the 91.8B PI clone containing the PKDl gene and flanking regions with only the relevant sites indicated (B=BamHI, C=SacI, E=EcoRI, N=NotI, S=SalI, X=XhoI and V=EcoRV) . The Notl site in parenthesis is methylated in genomic DNA. The position of the 1.9 kb BamHI-BamHI fragment is shown by the shaded box, the striped box denotes the location of the 2.5 kb polypurine/polypyrimidine tract. The arrows indicate the position and orientation of the next most centromeric transcript (NCT), TSC-2 and PKDl genes. The location of relevant cosmid clones is shown by open boxes. Restriction fragments used to generate sequencing templates are shown at the bottom with quotation marks denoting that the site is vector derived. Pools used in fluorescence in si tu hybridization (FISH) are indicated by brackets at the bottom. Figure 7 shows a comparison between the previously reported (EPKDC) partial PKDl cDNA (SEQ ID NOS:20, 21, 24, 25,28 and 29) sequence and the sequence reported herein (SEQ ID NOS: 22,23,26, 27, 30 and 31). The upper sequence is that reported for the cDNA (EPKDC) , while the lower sequence is the genomic sequence of the present invention. Discrepancies are highlighted by lower case in the cDNA (EPKDC) sequence and by boxes in the genomic sequence with the corresponding changes in amino acids denoted with X's. The altered carboxy-terminal residues resulting from the frame shift are shown above the genomic sequence and the previously predicted residues are shown in lowercase. An in-frame termination codon is indicated by an underline in the genomic sequence. Figure 8 shows an illustration of the PKDl genomic structure as predicted by GRAIL2. The predicted exons are represented as boxes along the genomic sequence. The reported cDNA is at the top right. The position of the 2.5 kb GC-rich region is indicated by the striped box at the bottom. The stippled box above exons 3 and 4 in the gene model indicate the position of the predicted LRR and carboxy-flanking region. The extent of the published cDNA is shown by the open (coding region) and cross hatched boxes (3' untranslated region) . The filled black box indicates the relative position of the exon which was absent in the predicted gene model, while the asterisk designates the exon which contains an unspliced intron. The position of the 2.5 kb GC-rich region is marked by the striped box below the GC-content bar. Figure 9 shows a schematic structure of the predicted PKDl protein. Multiple domains are depicted based on sequence homology including two copies of a leucine-rich repeat (LRR) near the N-terminal which is flanked by a cysteine-rich cluster (F) . Three perfect copies and 12 related copies of a domain of unknown function (Pmel-17 or Ig-like repeat) are shown. The predicted 7 (or more) membrane-spanning domains are indicated. The exons encoding the various domains are listed. Figure 10 shows the RT-PCR and cDNA products comprising the PKDl cDNA. The EPKDC 3' cDNA sequence is shown by the striped box. The full-length cDNA is shown in black. Shaded boxes denote individual cDNAs and RT-PCR products. The cross hatched box denotes the RT-PCR products containing alternatively spliced exons and an unspliced exon which do not maintain the open reading frame. Alternatively spliced exons and insertions are designated by thin lines and inverted triangles, respectively. Open boxes designate the position of open reading frames. The stippled box denotes the 5' untranslated region. Figure 11 shows a schematic structure of the full length PKDl cDNA in pCMV-SPORT vector. Thin line represents PKDl cDNA with restriction sites used to assemble individual cDNA clones. Thick line represents pCMV-SPORT vector which contains SP6 and T7 RNA polymerase promoters to generate RNA for in vitro translations, CMV promoter, SV40 origin of replication and polyadenylation signal for expression in mammalian cells. Figure 12 shows a schematic of the full-length PKDl product and its truncated products. Black box represents signal peptide (S) , Leucine rich repeat (LRR) and Ig-like (Ig-like) domains are indicated by shaded boxes. The eleven predicted transmembrane regions are also indicated by black bars and numbered. Figure 13 shows regions of homology in the PKDl gene between sequences encoded by GRAIL2-predicted exons and proteins present in SwissProt and PIR databases. (SEQ ID NOS: 32-55) . Positions where the PKDl sequence matches the consensus sequence are shaded. Figure 14 shows the results of exon trapping within the PKDl locus. Figure 15 shows the regions of PKDl protein used as fusion proteins for generation of domain specific polyclonal antibodies. The predicted structure of the PKDl protein is shown above. Each fusion protein consists of the carrier glutathione-S-transferase (GST) or maltose binding protein (MBP) and the indicated region of PKDl polypeptide. PKDl corresponding residues of each fusion protein are shown. Figure 16 shows the two constructs used for immunoprecipitation, SrflΔ, which corresponds to the N-terminal half of the PKDl protein and BRASH 7, which corresponds to the C-terminal half of the PKDl protein as shown. Epitopes for anti-fusion proteins FP-LRR, FP-46-lc and FP-46-2 polyclonal antibodies used for immunoprecipitations are also indicated. DETAILED DESCRIPTION OF THE INVENTION All patent applications, patents, and literature references cited in this specification are hereby incorporated by reference in their entirety. In case of conflict or inconsistency, the present description, including definitions, will control. Definitions: 1. "APKD" as used herein denotes adult-onset polycystic kidney disease, which is characterized by the development of renal cysts and, ultimately, renal failure, and may alternatively or in addition involve cysts in other organs including liver and spleen, as well as gastrointestinal, cardiovascular, and musculoskeletal abnormalities. 2. The term "PKDl gene" refers to a genomic DNA sequence which maps to chromosomal position 16pl3.3 and gives rise to a messenger RNA molecule encoding the PKDl protein. The PKDl gene encompasses the sequences shown in Figures 1 and 2, which includes introns and putative regulatory sequences. The term "authentic" is used herein to denote the genomic sequence at this location, as well as sequences derived therefrom, and serves to distinguish these authentic sequences from "PKDl homologues" (see below) . 3. "PKDl complementary DNA (cDNA) " is defined herein as a single-stranded or double-stranded intronless DNA molecule encompassing the sequence shown in Figure 3, that is derived from the authentic PKDl gene and whose sequence, or complement thereof, encodes the PKDl protein shown in Figure 3. 4. A "normal" PKDl gene is defined herein as a PKDl gene whose altered, defective, or non-functional expression leads to adult-onset polycystic kidney disease. A normal PKDl gene is not associated with disease and thus is considered to be a wild-type version of the gene. Included in this category are allelic variants in the PKDl gene, also denoted allelic polymorphisms, i.e. alternate versions of the PKDl gene, not associated with disease, that may be represented at any frequency in the population. Also included are alterations in DNA sequence, whether recombinant or naturally occurring, that have no apparent effect on expression or function of the PKDl gene product. 5. A "mutant" PKDl gene is defined herein as a PKDl gene whose sequence has been modified by transitions, transversions, deletions, insertions, or other modifications relative to the normal PKDl gene, which modifications cause detectable changes in the expression or function of the PKDl gene product, including causing disease. The modifications may involve from one to as many as several thousand nucleotides, and result in one or more of a variety of changes in PKDl gene expression, such as, for example, decreased or increased rates of expression, or expression of a defective RNA transcript or protein product. Mutant PKDl genes encompass those genes whose presence in one or more copies in the genome of a human individual is associated with APKD. 6. A "PKDl homologue" is a sequence which is closely related to PKDl, but which does not encode the authentic expressed PKDl gene product. Several examples of such homologues that map to chromosomal location 16pl3.1 have been identified and sequenced by the present inventors. 7. A "PKDl carrier" is defined herein as an individual who carries at least one copy of a disease- producing mutant PKDl gene. Since the disease generally exhibits an autosomal dominant pattern of transmission, PKDl carriers have a high probability of developing some symptom of PKD. Thus, a PKDl carrier is likely to be a "PKD patient. " 8. As referred to herein, a "contig" is a continuous stretch of DNA or DNA sequence, which may be represented by multiple, overlapping, clones or sequences. 9. As referred to herein, a "cosmid" is a DNA plasmid that can replicate in bacterial cells and that accommodates large DNA inserts from about 30 to about 45 kb in length. 10. The term "Pi clones" refers to genomic DNAs cloned into vectors based on the Pi phage replication mechanisms. These vectors generally accommodate inserts of about 70 to about 105 kb (Pierce et al., Proc. Natl . Acad. Sci . , USA, 89:2056-2060, 1992). 11. As used herein, the term "exon trapping" refers to a method for isolating genomic DNA sequences that are flanked by donor and acceptor splice sites for RNA processing. 12. The term "single-strand conformational polymorphism analysis" (SSCP) refers to a method for detecting sequence differences between two DNAs, comprising hybridization of the two species with subsequent mismatch detection by gel electrophoresis. (Ravnik-Glavac et al.. Hum. Mol . Genet . , 3:801, 1994). 13. "HOT cleavage" is defined herein as a method for detecting sequence differences between two DNAs, comprising hybridization of the two species with subsequent mismatch detection by chemical cleavage (Cotton, et al. , Proc . Na tl . Acad. Sci . , USA, 85:4397, 1988) . 14. "Denaturing gradient gel electrophoresis" (DDGE) refers to a method for resolving two DNA fragments of identical length on the basis of sequence differences as small as a single base pair change, using electrophoresis through a gel containing varying concentrations of denaturant (Guldberg et al., Nuc. Acids Res . , 22:880, 1994). 15. As used herein, "sequence-specific oligonucleotides" refers to related sets of oligonucleotides that can be used to detect allelic variations or mutations in the PKDl gene. 16. As used herein, "PKDl-specific oligonucleotides" refers to oligonucleotides that hybridize to sequences present in the authentic expressed PKDl gene and not to PKDl homologues or other sequences. 17. "Amplification" of DNA as used herein denotes a reaction that serves to increase the concentration of a particular DNA sequence within a mixture of DNA sequences. Amplification may be carried out using polymerase chain reaction (PCR) (Saiki et al., Science, 239:487, 1988), ligase chain reaction (LCR) , nucleic acid-specific based amplification (NSBA) , or any method known in the art. 18. "RT-PCR" as used herein refers to coupled reverse transcription and polymerase chain reaction. This method of amplification uses an initial step in which a specific oligonucleotide, oligo dT, or a mixture of random primers is used to prime reverse transcription of RNA into single-stranded cDNA; this cDNA is then amplified using standard amplification techniques e.g. PCR. 19. A PKDl gene or PKDl cDNA, whether normal or mutant, corresponding to a particular sequence is understood to include alterations in the particular sequence that do not change the inherent properties of the sequence. It will be understood that additional nucleotides may be added to the 5'- and/or 3'- terminus of the PKDl gene shown in Figure IB, or the PKDl cDNA shown in Figure 3, as part of routine recombinant DNA manipulations. Furthermore, conservative DNA substitutions, i.e. changes in the sequence of the protein- coding region that do not change the encoded amino acid sequence, may also be accommodated. The present invention encompasses the human gene for PKDl. Mutations in this gene are associated with the occurrence of adult-onset polycystic kidney disease. A "normal" version of the genomic sequence, corresponding to 53,526 bases of the PKDl gene is shown in Figure IB. The PKDl gene sequence was determined using the strategy described in Example 1. Briefly, a series of cosmid and PI DNA clones was assembled containing overlapping human genomic DNA sequences that collectively cover a 700 kilobase segment of chromosome 16 known to contain the PKDl locus. To identify transcribed sequences within this 700 kb segment, including those sequences encoding PKDl, both exon trapping and cDNA selection techniques were employed. At the same time, direct DNA sequencing of the human DNA sequences contained in the genomic clones was performed, using techniques that are well-known in the art. These included the isolation of subclones from particular cosmid or Pi clones. Nested deletions were created from selected subclones, and the nested deletions were then subjected to direct DNA sequencing using the ALF™ automated sequencer (Pharmacia, Uppsala, Sweden) . The full-length sequence of PKDl cDNA is shown in Figure 3. The present invention encompasses isolated oligonucleotides corresponding to sequences within the PKDl gene, or within PKDl cDNA, which, alone or together, can be used to discriminate between the authentic expressed PKDl gene and PKDl homologues or other repeated sequences. These oligonucleotides may be from about 12 to about 60 nucleotides in length, preferably about 18 nucleotides, may be single- or double-stranded, and may be labelled or modified as described below. An example of an oligonucleotide that can be used in this manner is shown in Figure 4B. The discrimination function of this oligonucleotide is based on a comparison of the sequence of the authentic PKDl gene with three cDNAs derived from the PKDl homologues, which revealed that homologue cDNAs contain a 29 bp insertion relative to the authentic PKDl sequence (Figure 4A) . The oligonucleotide shown in Figure 4B is modified at its 3 ' terminus so that it does not support polymerization reactions, and is designed to hybridize specifically to the homologue sequence and not to the authentic PKDl sequence. When this oligonucleotide is included in amplification reactions, it selectively prevents the amplification of PKDl homologue sequences. In this manner, authentic PKDl sequences are selectively amplified and PKDl homologues are not. These oligonucleotides or their functional equivalents thus provide a basis for testing for the presence of mutations in the authentic PKDl gene in a human patient (see Example 5 below) . The present invention encompasses isolated DNA and RNA sequences, including sense and antisense sequences, derived from the sequences shown in Figures 1, 2, and 3. The particular sequences may represent "normal" alleles of PKDl, including allelic variants, or "mutant" alleles, which are associated with disease symptoms. PKDl-derived sequences may also be associated with heterologous sequences, including promoters, enhancers, response elements, signal sequences, polyadenylation sequences, and the like. Furthermore, the nucleic acids can be modified to alter stability, solubility, binding affinity, and specificity. For example, PKDl-derived sequences can be selectively methylated. The DNA may comprise antisense oligonucleotides, and may further include nuclease-resistant phosphorothioate, phosphoroamidate, and methylphosphonate derivatives, as well as "protein nucleic acid" (PNA) formed by conjugating bases to an amino acid backbone as described in Nielsen et al., Science, 254: 1497, 1991. The DNA may be derivatized by linkage of the α-anomer nucleotide, or by formation of a methyl or ethyl phosphotriester or an alkyl phosphoramidate linkage. Furthermore, the nucleic acid sequences of the present invention may also be modified with a label capable of providing a detectable signal, either directly or indirectly. Exemplary labels include radioisotopes, fluorescent molecules, biotin, and the like. In general, nucleic acid manipulations according to the present invention use methods that are well known in the art, as disclosed in, for example, Molecular Cloning, A Laboratory Manual (2nd Ed., Sambrook, Fritsch and Maniatis, Cold Spring Harbor) , or Current Protocols in Molecular Biology (Eds. Ausubel, Brent, Kingston, More, Feidman, Smith and Struhl, Greene Publ. Assoc. , Wiley-Interscience, NY, NY, 1992) . The invention also provides vectors comprising nucleic acids having PKDl or PKDl-related sequences. A large number of vectors, including plasmid, phage, viral and fungal vectors, have been described for expression in a variety of eukaryotic and prokaryotic hosts, and may be used for gene therapy as well as for simple protein expression. Advantageously, vectors may also include a promoter operably linked to the PKDl- encoding portion, particularly when the PKDl-encoding portion comprises the cDNA shown in Figure 3 or derivatives or fragments thereof. The encoded PKDl may be expressed by using any suitable vectors, such as pREP4, pREP8, or pCEP4 (InVitrogen, San Diego, CA) , and any suitable host cells, using methods disclosed or cited herein or otherwise known to those skilled in the relevant art. The particular choice of vector/host is not critical to the operation of the invention. Recombinant cloning vectors will often include one or more replication systems for cloning or expression, one or more markers for selection in the host, e.g. antibiotic resistance,, and one or more expression cassettes. The inserted PKDl coding sequences may be synthesized, isolated from natural sources, or prepared as hybrids, for example. Ligation of the PKDl coding sequences to transcriptional regulatory elements and/or to other amino acid coding sequences may be achieved by known methods. Suitable host cells may be transformed/transfected/infected by any suitable method including electroporation, CaCl 2 mediated DNA uptake, fungal infection, microinjection, microprojectile, or other established methods. Appropriate host cells included bacteria, archebacteria, fungi, especially yeast, and plant and animal cells, especially mammalian cells. Of particular interest are E. coli , B. Subtilis, Saccharomyces cerevisiae, SF9 cells, C129 cells, 293 cells, Neurospora, and CHO cells, COS cells, HeLa cells, and immortalized mammalian myeloid and lymphoid cell lines. Preferred replication systems include M13, ColEl, SV40, baculovirus, lambda, adenovirus, artificial chromosomes, and the like. A large number of transcription initiation and termination regulatory regions have been isolated and shown to be effective in the transcription and translation of heterologous proteins in the various hosts. Examples of these regions, methods of isolation, manner of manipulation, and the like, are known in the art. Under appropriate expression conditions, host cells can be used as a source of recombinantiy produced PKDl. This invention also contemplates the use of unicellular or multicellular organisms whose genome has been transfected or transformed by the introduction of PKDl coding sequences through any suitable method, in order to obtain recombinantiy produced PKDl protein or peptides derived therefrom. Nucleic acids encoding PKDl polypeptides may also be incorporated into the genome of recipient cells by recombination events. For example, such a sequence can be microinjected into a cell, and thereby effect homologous recombination at the site of an endogenous gene encoding PKDl, an analog or pseudogene thereof, or a sequence with substantial identity to a PKDl-encoding gene. Other recombination-based methods such as nonhomologous recombinations or deletion of endogenous gene by homologous recombination, especially in pluripotent cells, may also be used. The present invention also encompasses an isolated polypeptide having a sequence encoded by the authentic PKDl gene, as well as peptides of six or more amino acids derived therefrom. The polypeptide(s) may be isolated from human tissues obtained by biopsy or autopsy, or may be produced in a heterologous cell by recombinant DNA methods as described above. Standard protein purification methods may be used to isolate PKDl-related polypeptides, including but not limited to detergent extraction, and chromatographic methods including molecular sieve, ion-exchange, and affinity chromatography using e.g. PKDl-specific antibodies or ligands. When the PKDl polypeptide to be purified is produced in a recombinant system, the recombinant expression vector may comprise additional sequences that encode additional amino-terminal or carboxy-terminal amino acids,- these extra amino acids act as "tags" for immunoaffinity purification using immobilized antibodies or for affinity purification using immobilized ligands. Peptides comprising PKDl-specific sequences may be derived from isolated larger PKDl polypeptides described above, using proteolytic cleavages by e.g. proteases such as trypsin and chemical treatments such as cyanogen bromide that are well-known in the art. Alternatively, peptides up to 60 residues in length can be routinely synthesized in milligram quantities using commercially available peptide synthesizers. The present invention encompasses antibodies that specifically recognize the PKDl polypeptide(s) encoded by the gene shown in Figures 1 and 2 or the cDNA shown in Figure 3, and/or fragments or portions thereof. The antibodies may be polyclonal or monoclonal, may be produced in response to the native PKDl polypeptide or to synthetic peptides as described above. Such antibodies are conveniently made using the methods and compositions disclosed in Harlow and Lane, Antibodies, A Laboratory Manual , Cold Spring Harbor Laboratory, 1988, other references cited herein, as well as immunological and hybridoma technologies known to those in the art. Where natural or synthetic PKDl-derived peptides are used to induce a PKDl-specific immune response, the peptides may be conveniently coupled to an suitable carrier such as KLH and administered in a suitable adjuvant such as Freund's. Preferably, selected peptides are coupled to a lysine core carrier substantially according to the methods of Tarn, Proc . Natl . Acad. Sci , USA 85:5409-5413, 1988. The resulting antibodies may be modified to a monovalent form, such as, for example, Fab, Fab 2 , FAB', or FV. Anti-idiotypic antibodies may also be prepared using known methods. In one embodiment, normal or mutant PKDl polypeptides are used to immunize mice, after which their spleens are removed, and splenocytes used to form cell hybrids with myeloma cells and obtain clones of antibody- secreted cells according to techniques that are standard in the art. The resulting monoclonal antibodies are screened for specific binding to PKDl proteins or PKDl-related peptides. In another embodiment, antibodies are screened for selective binding to normal or mutant PKDl sequences. Antibodies that distinguish between normal and mutant forms of PKDl may be used in diagnostic tests (see below) employing ELISA, EMIT, CEDIA, SLIFA, and the like. Anti-PKDl antibodies may also be used to perform subcellular and histochemical localization studies. Finally, antibodies may be used to block the function of the PKDl polypeptide, whether normal or mutant, or to perform rational drug design studies to identify and test inhibitors of the function (e.g. , using an anti-idiotypic antibody approach) . Identification of Disease-Causing Mutations in PKDl In one mode of practice of the present invention, the isolated and sequenced PKDl gene is utilized to identify previously unknown or mutant versions of the PKDl gene. First, human subjects with inherited polycystic kidney disease are identified by clinical testing, pedigree analysis, and linkage analysis, using standard diagnostic criteria and interview procedures, and DNA or RNA samples are obtained from the subjects (see below) . A variety of techniques are then employed to pinpoint new mutant sequences. First, PKDl DNA may be subjected to direct DNA sequencing, using methods that are standard in the art. Furthermore, deletions may be detected using a PCR-based assay, in which pairs of oligonucleotides are used to prime amplification reactions and the sizes of the amplification products are compared with those of control products. Other useful techniques include Single-Strand Conformation Polymorphism analysis (SSCP) , HOT cleavage, denaturing gradient gel electrophoresis, and two-dimensional gel electrophoresis. A confounding and complicating factor in the detection of a PKDl mutation is the presence of PKDl homologues at several sites on chromosome 16 proximal to the transcribed gene. In analysis of mutations in PKDl, it is critical to distinguish between sequences derived from the authentic PKDl gene and sequences derived from any of the homologues. Thus, an important feature of the present invention is the provision of oligonucleotide primers that discriminate between authentic PKDl and the homologues. A detailed comparison of the sequences of the authentic PKDl gene and the homologues enables the design of primers that discriminate between the authentic PKDl gene or cDNA and the homologues. Primers that conform to this criterion, such as those disclosed in Figure 4B, may be used in conjunction with any of the analytical methods described below. For SSCP, primers are designed that amplify DNA products of about 250-300 bp in length across non-duplicated segments of the PKDl gene. For each amplification product, one gel system and two running conditions are used. Each amplification product is applied to a 10% polyacrylamide gel containing 10% glycerol. Separate aliquots of each amplimer are subjected to electrophoresis at 8W at room temperature for 16 hours and at 30W at 4°C for 5.4 hours. These conditions were previously shown to identify 98% of the known mutations in the CFTR gene (Ravnik-Glavac et al., Hum. Mol . Genet . , 3:801, 1994) . For "HOT" cleavage, amplification reactions are performed using radiolabelled PKDl-specific primers. Each radiolabelled amplification product is then mixed with a 10- fold to 100-fold molar excess of unlabelled amplification products produced using the identical primers and DNA from APKD-affected or -unaffected subjects. Heteroduplex formation, chemical cleavage, and gel analysis are then performed as described (Cotton, et al., Proc. Natl . Acad. Sci . , USA, 85:4397, 1988). Bands on the gel that are smaller than the homoduplex result from chemical cleavage of heteroduplexes at base pair mismatches involving cytidine or thymidine. Once a mutation has been identified by this procedure, the exact location of the mismatch(es) is determined by direct DNA sequencing. Mutations are also identified by "broad range" DDGE (Guldberg et al., Nuc. Acids Res . , 22:880, 1994) . The use of GC-clamped PCR primers and a very broad denaturant gradient enables the efficient detection of mutant sequences. This method can also be combined with non-denaturing size fractionation in a two-dimensional system. An apparatus is used that permits automated two-dimensional electrophoresis, and the second dimension considerably increases the resolution of mutations. After the presence of a mutation is detected by any of the above techniques, the specific nucleic acid alteration comprising the mutation is identified by direct DNA sequence analysis. In this manner, previously unidentified PKDl mutations may be defined. Once a previously unidentified PKDl mutation is defined, methods for detecting the particular mutation in other affected individuals can be devised, using a variety of methods that are standard in the art. For example, oligonucleotide probes may be prepared that allow the detection and discrimination of the particular mutation. It will be understood that such probes may comprise either the mutant sequence itself, or, alternatively, may flank the mutant sequence. Furthermore, the oligonucleotide sequence can be used to design a peptide immunogen comprising the mutant amino acid sequence. These peptides are then used to elicit antibodies that distinguish between normal and mutant PKDl polypeptides. Diagnostic Tests for PKDl Mutations Mutant PKDl genes, whether identified by the methods described above or by other means, find use in the design and operation of diagnostic tests. Tests that detect the presence of mutant PKDl genes, including those described below and in Example 5, can be applied in the following ways: (1) To determine donor suitability for kidney transplants. In general, it is desirable to use a close relative of the transplant recipient. When the recipient is a patient suffering from familial APKD, it is important to ascertain that the donor relative does not also carry the familial mutant PKDl gene. (2) To screen for at-risk individuals in APKD- affected families. Presymptomatic individuals who have a high probability of developing APKD can be identified, allowing them to be monitored and to avail themselves of preventive therapies. (3) To target hypertensive patients for antihypertensive treatment. Hypertension is also linked to APKD. Screening of hypertensive patients for the presence of mutant PKDl genes can be used to identify patients for preemptive regulation of blood pressure to prevent later kidney damage. (4) To perform prenatal screening. Most PKD1- linked PKD is of the adult-onset type. In a small subset of families carrying a mutation in PKDl genes, however, juvenile onset is common and signifies a more severe form of the disease. In these families, prenatal screening can be useful for genetic counselling purposes. In general, the diagnostic tests according to the present invention involve obtaining a biological sample from a subject, and screening the sample, using all or part of the PKDl gene of this invention, for the presence of one or more mutant versions of the PKDl gene or its protein product. The subject may be a fetus in utero, or a human patient of any age. In one embodiment, a sample of genomic DNA is obtained from a human subject and assayed for the presence of one or more disease-associated PKDl mutations. This DNA may be obtained from any cell source or body fluid. Non-limiting examples of cell sources available in clinical practice include blood cells, buccal cells, cervicovaginal cells, epithelial cells from urine, fetal cells, or any cells present in tissue obtained by biopsy. Body fluids include blood, urine, cerebrospinal fluid, amniotic fluid, and tissue exudates at the site of infection or inflammation. DNA is extracted from the cell source or body fluid using any of the numerous methods that are standard in the art. It will be understood that the particular method used to extract DNA will depend on the nature of the source. The minimum amount of DNA to be extracted for use in the present invention is about 25 pg (corresponding to about 5 cell equivalents of a genome size of 3 x 10 9 base pairs) . In this embodiment, the assay used to detect the presence of mutations may comprise restriction enzyme digestion, direct DNA sequencing, hybridization with sequence-specific oligonucleotides, amplification by PCR, single-stranded conformational polymorphism analysis. denaturating gradient gel electrophoresis (DDGE) , two- dimensional gel electrophoresis, in si tu hybridization, and combinations thereof. In a preferred embodiment, RNA is isolated from a PKDl-expressing cell or tissue, preferably lymphocytes, using standard techniques including automated systems such as that marketed by Applied Biosystems, Inc. (Foster City, CA) . The RNA is then subjected to coupled reverse-transcription and PCR amplification (RT-PCR) . The resulting DNA may then be screened for the presence of mutant sequences by any of the methods outlined above (see Example 5 below) . As discussed above, any nucleic-acid-based screening method for PKDl mutations must be able to discriminate between the authentic PKDl gene present at chromosome location 16pl3.3 and PKDl homologues present at 16pl3.1 and other locations. The oligonucleotides (i.e., SEQ ID Nos:10 and 13-15) are examples of primers that discriminate between the authentic and homologue sequences, and these oligonucleotides or their equivalents form an important part of any such diagnostic test. Furthermore, nucleotides 43,823 through 52,887 of the PKDl sequence of Figure IB represent a sequence that is unique to the authentic PKDl gene and is not present in the homologues. Thus, oligonucleotides derived from this region can be used in a screening method to insure that the authentic PKDl gene, and not the homologues, are detected. In another embodiment, the assay used to detect the presence of a mutant PKDl gene involves testing for mutant gene products by an immunological assay, using one of many methods known in the art, such as, for example, radioimmunoassay, ELISA, immunofluorescence, and the like. In this embodiment, the biological sample is preferably derived from a PKDl-expressing tissue such as kidney. The PKDl polypeptide may be extracted from the sample. Alternatively, the sample may be treated to allow detection or visualization of specifically bound antibodies in situ as occurs in, for example, cryosectioning followed by immunofluorescent staining. The antibodies may be monoclonal or polyclonal, may be raised against intact PKDl protein, or natural or synthetic peptides derived from PKDl. In a preferred embodiment, the antibodies discriminate between "normal" and "mutant" PKDl sequences, and possess a sufficiently high affinity for PKDl polypeptides so that they can be used in routine assays. It will be understood that the particular method or combination of methods used will depend on the particular application. For example, high-throughput screening methods preferably involve extraction of DNA or RNA from an easily available tissue, followed by amplification of particular PKDl sequences and hybridization of the amplification products with a panel of specific oligonucleotides. Therapeutic Applications The present invention encompasses the treatment of PKD using the methods and compositions disclosed herein. All or part of the normal PKDl gene disclosed above can be delivered to kidney cells or other affected cells using a variety of known methods, including e.g. liposomes, viral vectors, recombinant viruses, and the like. The gene can be incorporated into DNA vectors that additionally comprise tissue-specific regulatory elements, allowing PKDl expression in a tissue-specific manner. This approach is feasible if a particular mutant PKDl allele, when present in a single copy, merely causes the level of the PKDl protein to diminish below a threshold level necessary for normal function; in this case, increasing the gene dosage by supplementing with additional normal copies of the PKDl gene should correct the functional defect. In another embodiment, a mixture of isolated nucleic acids, such as that set forth in Figure 2 and at least a portion of the normal PKDl gene, may be delivered to kidney or other affected cells in order to treat APKD. Alternatively, it may be desired to limit the expression of a mutant PKDl gene, using, for example, antisense sequences. In this embodiment, antisense oligonucleotides may be delivered to kidney or other cells. For therapeutic uses, PKDl-related DNA may be administered in any convenient way, for example, parenterally in a physiologically acceptable carrier such as phosphate buffered saline, saline, deionized water, or the like. Typically, the compositions are added to a retained physiological fluid such as blood or synovial fluid. The amount administered will be empirically determined using routine experimentation. Other additives, such as stabilizers, bactericides, and the like, may be included in conventional amounts. This invention also encompasses the treatment of APKD by protein replacement. In one embodiment, protein produced by host cells transformed or transfected with DNA encoding the PKDl polypeptide of the present invention is introduced into the cells of an individual suffering from altered, defective, or non-functional expression of the PKDl gene. This approach augments the absence of PKDl protein, or the presence of a defective PKDl protein, by adding functional PKDl protein. The PKDl protein used in augmentation may comprise a subcellular fragment or fraction, or may be partially or substantially purified. In any case, the PKDl protein is formulated in an appropriate vehicle, such as, for example, liposomes, that may additionally include conventional carriers, excipients, stabilizers, and the like. It will be understood that the therapeutic compositions of the present invention need not in themselves constitute an effective amount, since such effective amounts can be reached by administering a plurality of such therapeutic compositions. The following examples are intended to illustrate the invention without limiting its scope thereof. Example 1: Cloning and Sequencing of the Human PKDl αene A. Methods: Employing an ordered sequencing approach, restriction fragments from cDEBll and cGGGl0.2 cosmids were subcloned into either pBLUESCRIPT (Stratagene, La Jolla, CA) or pGEM (Promega, Madison, WI) . Plasmids were purified by CsCl density centrifugation in the presence of ethidium bromide. Nested deletions were generated from each plasmid using ExoIII (Henikoff, S., Methods Enzymol . 155: 156-165, 1987) and additional enzymatic reagents provided by the Erase-A-Base kit (Promega, Madison, WI) . The resulting nested clones were analyzed electrophoretically after appropriate restriction enzyme digestion and were ordered into a nested set of templates for sequencing. A minimum tiling series of plasmids, each differing by approximately 250 bp from flanking clones, were identified and used for sequencing. Plasmid DNAs were prepared for sequencing in one of two ways. Initially, all clones of interest were cultured in 2 mL of Super Broth (Tartof et al. , BRL Focus 9: 12, 1987) for 20 hours at 37°C. Sets of 12-24 were processed simultaneously using a modified alkaline SDS procedure followed by ion-exchange chromatography as described by the manufacturer (Easy-Prep, Pharmacia, Piscataway, NJ) . Plasmid DNA yields ranged from 2.5 to 25 μg. Poor growing clones, or those whose plasmids generated sequence of unacceptable quality, were recultured in 100 mL of Luria's Broth and the plasmid DNA isolated using Qiagen columns (Qiagen, San Diego, CA) . Dideoxy sequencing reactions were performed on deletion clones using the Auto-Read Sequencing Kit (Pharmacia, Piscataway, NJ) and fluorescein-labeled vector primers (M13 universal, M13 reverse, T3, T7 and SP6) . Reaction products were separated on 6% denaturing acrylamide gels using the ALF™ DNA Sequencer (Pharmacia, Piscataway, NJ) . Second strand sequencing was performed using either an opposing set of nested deletions or primer walking. For primer walking, custom 17-mers, staggered every 250 bp, were purchased from a commercial supplier (Protogene, Palo Alto, CA) . Template DNAs prepared by Qiagen or CsCl density gradients were sequenced using the unlabeled 17-mers by inclusion of fluor-dATP labeling mix in the sequencing reactions as described by the manufacturer (Pharmacia, Piscataway, NJ) . In all cases, except the 2.5kb GC-rich region, single-stranded DNA was rescued from deletion clones using helper phage VCSM13 (Stratagene) as described by the manufacturer. Single-stranded templates from the 2.5 kb GC-rich region were sequenced using fluorescein-labeled universal primer and the Sequitherm Long Read cycle sequencing kit (Epicentre Technologies, Madison, WI) (Zimmerman et al. , Biotechniqxies 17: 303-307, 1994). All processed sequencing data was transferred to a Quadra 700 Macintosh computer and assembled using the SEQUENCHER (Gene Codes, Ann Arbor, MI) sequencing assembly program. For differences that would not be resolved by examining the chromatograms, templates were either resequenced or primers proximal to the ambiguity were designed and used for resolution of the sequence difference. Cycle sequencing was performed using the Sequitherm cycle sequencing kit as described by the manufacturer (Epicentre Technologies, Madison, WI) . Reaction products were separated on denaturing acrylamide gels and subsequently detected by autoradiography. B. Sequencing Strategy: A 700 kb region of chromosome 16 containing the PKDl locus is shown in Figure 5 (top panel) . A contig covering this region was assembled from overlapping PI clones (shown in the middle panel) . The contig was assembled by unidirectional chromosomal walking from the ends of the interval (ATPL and D16S84) and bidirectional walking from several internal loci (D16S139 and KG8) . One of the clones, 91.8B (ATCC Accession No. 98056), spans the entire PKDl interval and includes cosmids cDEBll (ATCC Accession No. 98057), cGGGlO.2 (ATCC Accession No. 98058), and substantial portions of cosmids 2H2 and 325A11 (Stallings, R.L. et al., Genomics 13:1031, 1992). The PI clone 91.8B (shown schematically in Figure 6) was used as a second genomic template to confirm discrepancies between the published cDNA sequence (EPKDC, Cell , 1994, supra) and the cosmid-derived genomic sequence. Preliminary experiments revealed the presence of multiple repetitive elements in the cGGGlO.2 cosmid. Therefore, an ordered approach based on nested deletions, rather than random shotgun subcloning, was used to sequence the PKDl gene. Restriction fragments derived from the inserts of both cGGGlO.2 and cDEBll were subcloned into high- copy number plasmids as a preliminary step to the generation of nested deletions. Unidirectional deletions were prepared and sequenced, using the ALF™ automated sequencing system (Pharmacia, Uppsala, Sweden) . C. Primary Structure of the PKDl Locus: The primary sequence of the locus encompassing the PKDl gene is 53,577 bp in length. This locus is GC-rich (62.4%), with a CpG/GpC dinucleotide ratio of 0.485. The primary sequence of the PKDl gene within this locus is 53,526 bp in length. The present sequence was analyzed for transcriptional elements and CpG islands using GRAIL2 (Uberbacher, E.C. et al., Proc . Natl . Acad. Sci . , USA 88:11261, 1991) and XGrail client server (Shah et al. , User 's Guide to GRAIL and GENQUEST, Client-Server Systems, available by anonymous ftp to arthur.epm.omi.gov (128.219.9.76) from directory pub/xgrail or pub/xgenquest, as file manual.grail- genquest, 1994) . Ten CpG islands were identified (Figure 8) . Forty-eight exons were predicted on the coding strand by the GRAIL program. The quality of 39 of the 48 exons was "excellent", six were considered "good", and three were deemed "marginal". These data were analyzed using the gene model feature of GRAIL2. The final gene model contained 46 exons. Comparison of the present genomic sequence with the previously reported partial cDNA sequence (EPKDC, Cell , 1994, supra) revealed several differences (Figure 7) . The first and most significant difference is the presence of two additional cytosine residues at position 4566 of the reported sequence. The presence of these two cytosine residues results in a frame shift in the predicted protein coding sequence, leading to the replacement of 92 carboxy-terminal amino acids with a novel 12-amino acid carboxy terminus. Seven of the twelve amino acids of the new carboxy terminus are charged or polar. Additional sequence differences are located at positions 3639-3640 and 3708-3709 of the published EPKDC sequence (Figure 7) . A GC dinucleotide pair is present at each of these positions in the present sequence, while a CG pair is found in the reported sequence. In each case, histidine and valine residues would replace the previously predicted glutamine and leucine residues, respectively. D. Identification of Protein Coding Regions: Exons predicted by the GRAIL2 program with an "excellent" score were used to search the SwissProt and PIR databases (Bairoch and Boeckmann, Nuc. Acids Res . 20:2019- 2022, 1992) using the BLASTP program (Altschul et al., J. Mol . Biol . 215:403-410, 1990) . Exons 3 and 4 of the gene model were predicted to encode peptides with homology to a number of leucine-rich repeat (LRR)-containing proteins involved in protein-protein interactions (Figure 13). In addition to the LRR itself, sequences amino- and carboxy- flanking to the LRR may also be conserved in proteins of the leucine-rich glycoprotein (LRG) family, either singly or together. Exon 3 encodes residues homologous to the LRR from leucine-rich α2 glycoprotein, members of the GPlb.IX complex which comprise the von Willebrand factor receptor, as well as to the Drosophila proteins chaoptin, toll , and sli t . The latter are involved in adhesion, dorsal-ventral polarity, and morphogenesis, respectively. Sequences predicted by GRAIL2 to be encoded by exon 4 were found to have homology to the conserved region carboxy terminal to the LRR in all of the above proteins except chaoptin, which lacks this conserved region. Homology was also observed between the exon 4-encoded sequences and the trk proto-oncogene, which encodes a receptor for nerve growth factor. Further examination of the predicted PKDl peptide revealed additional regions of weaker homology with conserved regions of the trk tyrosine kinase domain. None of the more proximal exons in the gene model appear to encode a peptide with homology to the conserved amino-flanking region seen in a subset of the LRR-containing proteins. Exon trapping, RT-PCR, and Northern blot analysis revealed that GRAIL2-predicted exons 3 and 4 are present in expressed sequences. During initial exon trapping experiments using genomic PI and cosmid clones from the PKDl locus, an exon trap was identified that contained both of these exons. In separate experiments, the presence of the LRR-carboxy-flanking motif in transcribed sequences was confirmed by RT-PCR using as a template RNA from fetal kidney and from adult brain. On a Northern blot, an RT-PCR fragment containing this motif detected the 14kb PKDl transcript and several other transcripts of 21 kb, 17 kb, and 8.5 kb. A region of homology was also observed between the GRAIL2-predicted peptide and the human gpl00/Pmell7 gene products, as well as with bovine RPEl. Three copies of a 34 amino acid segment that is also present in the Pmel-17 and gplOO gene products was deduced (Kwon et al, Proc . Natl . Acad. Sci . , USA 88:9228-9232, 1991; Adema et al. , J. Biol . Chem. 269:20126-33, 1994) within the larger context of immunoglobulin repeat motifs. The RPEl gene product has significant homology to gplOO and may represent the bovine homolog (Kim and Wistow, Exp. Eye Res. 55:657-662, 1992). GRAIL2-predicted exons 9, 22, and 28, upstream of the 3' cDNA, showed strong homology to EST T03080 (85%, 255 bp) , EST T04943 (98%, 189 bp) and EST T05931 (94%, 233 bp) . In addition, nucleotides 10378-10625 of GRAIL-predicted intron 1 showed strong homology to a region of the Apo CII gene (81%, 263 bp) . The identification of a number of transmembrane domains and a leucine-rich repeat motif possessing conserved carboxy-flanking regions, raises interesting speculations about potential protein function. LRR. motifs have been shown to be involved in protein-protein interactions, while the conserved carboxy-flanking region is associated with proteins which interact with the extracellular matrix. These data suggest that the PKDl gene product may be a membrane glycoprotein that functions in cell-matrix or cell-cell interactions. Less commonly, LRR motifs have been identified in receptors involved in signal transduction (McFarland et al., Science 245:494-499, 1989). Thus an alternative hypothesis is that the gene product is a receptor for a soluble factor(s). In either case, PKDl would function to mediate interactions with the extracellular environment. If so, ligands for the gene product as well as downstream intracellular effectors are obvious candidates for the non-chromosome 16-linked forms of the disease. A model of the predicted PKDl protein structure is shown in Figure 9. E. Repeated Sequences: The PKDl locus was searched for known classes of repetitive DNA by FASTA comparison against the repeat database of Jurka et al. , J.Mol . Evol . 35:286-291, 1992. This search identified 23 Alu repeats but no other repetitive elements. The Alu repeats are organized into three clusters of four or more Alu repeats, three clusters of two Alu repeats, and two singlet Alu repeats (Figure 8) . The PKDl sequence interval contained two dinucleotide repeats (>(TG)8) and a single tetranucleotide repeat ((TTTA)6). The TG dinucleotide repeats are present at positions 209-224 and 52,698-52,715. The tetranucleotide repeat is located at position 7796-7819. No trinucleotide repeats >5 were identified. Only the most 3' TG8 repeat is known to be polymorphic. In addition to the more usual repetitive elements, the PKDl gene contains several types of repeated sequences that either do not appear in existing data bases, or do not appear in the extreme form seen at this locus. The most striking repeat is a 2.5 kb segment within the 4 kb BamHI- Sacl fragment. A significantly shorter C-T rich region is also found in the adjoining 1.8 kb SacI-BamHI fragment. These regions proved very difficult to sequence unambiguously due to the high GC content (65%) , to the purine asymmetry with respect to each strand and to the length of the repeat. The coding strand in this region has an extreme pyrimidine bias, being 96% C-T, and could not be sequenced using T7 DNA polymerase or Sequenase. This was true regardless of the template type (plasmid, single-stranded phage, or strand- separated single-stranded DNA) . In both cases, the non- coding strand, which is G-A rich, was successfully sequenced with both T7 DNA polymerase and Sequenase, although run lengths were noticeably abbreviated compared to all other regions sequenced. Compressions on the non-coding strand were resolved by conventional and cycle sequencing using single-stranded template. The extreme purine asymmetry of strands in this segment may promote localized triple strand conformation under the appropriate conditions (pH, divalent cations, supercoiling) , and may be a major cause of the difficulty in sequencing this segment. The other unusual repeat was located in the 7.6 kb Xhol fragment. This repeat is 459 bp in length and consists of 17 tandem copies of a perfect 27 bp repeat. Example 2 : PKDl cDNA Sequences Obtained Through Exon Trapping and cDNA Selection Techniques The 700 kb interval of chromosome 16 that includes the PKDl gene appears to be particularly rich in CpG islands and, by association, is most likely rich in expressed sequences as well. To purify and sequence expressed PKDl sequences, an exon-rescue vector, pSPL3, was used to recover sequences from cosmids that contain both a splice acceptor and splice donor element; this method is designated "exon trapping. " Exon trapping is a highly efficient method for isolating expressed sequences from genomic DNA. The procedure utilizes the pSPL3 plasmid, which contains rabbit β-globin coding sequences separated by a portion of the HIV- tat gene, or improved derivatives of SPL3 lacking cryptic (interfering) splice sites. Fragments of cloned PKDl genomic DNA were cloned into the intron of the tat gene, and the resulting subclones were transfected into COS-7 cells. SV40 sequences in the vector allow for both relaxed episomal replication of the transfected vectors, as well as transcription of the cloned genomic DNAS. Exons within the subcloned genomic DNAs spliced into the globin/tat transcript were recovered using RT-PCR, using primers containing tat splice donor and acceptor sequences. A major advantage of exon trapping is that expression of the cloned DNA is directed by a viral promoter; thus, developmental or tissue- specific expression of gene products is not a concern. PKDl-containing genomic clones, in the form of either cosmid or PI DNA, were either double digested with BamHI and Bglll or partially digested with Sau3A and shotgun cloned into BamHI-digested and dephosphorylated pSPL3 (GIBCO BRL, Bethesda, MD) or its derivatives. Plasmid minipreps were electroporated into COS-7 cells, and trapped exons were recovered by RT-PCR, followed by subcloning, using standard procedures. Trapped exons from the PKDl locus are shown in Figure 14 (bottom) . The trapped exons were subjected to automated DNA sequencing as above, allowing their alignment with the genomic PKDl DNA. Example 3: Construction of Full-length PKDl cDNA In the case of PKDl, the identification of cDNAs which are specific for the 5 ' end of the PKDl locus is particularly difficult since multiple transcribed copies of homologous sequences are also present at 16pl3.1 (EPKDC, Cell, 1994 supra) . Regions of both genomic DNA and cDNA derived from the homologues were sequenced and compared with the present PKDl sequence. In this data set, the PKDl and homologous sequences were greater than 97% identical at the nucleotide level. Therefore, direct comparisons of potential PKDl cDNAs and genomic sequence are required to definitively map a cDNA to the PKDl locus, and to verify that the correct sequence is encoded by the cDNA. Multiple approaches were required to assemble the full-length PKDl cDNA. Seven cDNAs were used to construct the full-length cDNA. Five of these cDNAs were recovered from screening cDNA libraries: the BRL Gene-Trapper brain library, and cDNA libraries constructed from fetal brain, and constructed from the somatic cell hybrid 145.19. The 145.19 cell line contains the PKDl locus, but does not include the PKDl homologs in its human component. A. cDNA Library Construction and Screening The somatic cell hybrid library was constructed using both oligo(dT) and random hexamer priming and poly(A)-containing RNA from the 145.19 cell line. The duplex cDNA was linked and then ligated into lambda ZAP EXPRESS (Stratagene, La Jolla, CA) to yield a library consisting of several million independent plaques. Fourteen clones were positive by colony hybridization using a PKDl specific probe, with inserts ranging in size from 2.6 to 9 kb. Consistent with the RT-PCR products derived from the 145.19 cell line, substantial alternative splicing or incomplete splicing was evident. Interestingly, the missing exons appeared to comprise one or more distinct protein domains. Two additional libraries were constructed using fetal brain cDNA cloned into lambda ZAP EXPRESS and the replacement vector, lambda DASH (Stratagene, La Jolla, CA) . Additionally, a variation of the cDNA selection methodology was used to screen oligo(dT)-primed, unidirectional cDNA libraries (in phagemids) . Briefly, single-stranded library DNA was prepared from cultures of the adult brain cDNA library. A single biotinylated 17-mer derived from the sense-strand from the gene-specific portion of the predicted PKDl cDNA was used for hybrid selection. Hybrid-bound cDNAs released by denaturation were made double-stranded using the same oligonucleotide as a gene-specific primer and Klenow and then introduced into E. coli by electroporation. Colony hybridization was used to identify the PKDl clones from the enriched brain cDNA population. The cloned brain inserts ranged in size from 0.7 to 2.5 kb. The sequence of the two largest cDNAs was virtually identical to each other as well as to the genomic sequence. Example 4: Expression of Full-Length PKDl cDNA Full-length PKDl cDNA was cloned into three expression vectors, pCMV-SPORT, pcDNA3, and pCEP4 (total construct sizes ranging from 18-24.2 kb) . The schematic structure of full-length PKDl cDNA in pCMV-SPORT is shown in Figure 11. pCMV-SPORT and pcDNA3 have small differences in cloning sites and some other small features, but share the basic features of flanking T7 and SP6 promoters, CMV enhancer-promoter sequences for high level transcription, and eukaryotic polyadenylation and transcription sequences which enhance RNA stability. The SV40 origin of replication allows growth in eukaryotic cells, while the ColEl origin allows growth in E. coli . The vector pcDNA3 confers neomycin resistance in eukaryotes, while ampicillin resistance is used for selection in E. coli . pCEP4 is an EBV-based vector which is maintained extrachromosomally in primate cells. Like pCMV-SPORT and pcDNA3, pCEP4 contains the CMV enhancer and promoter, and the ColEl origin of replication and ampicillin resistance are used for maintenance. However, hygromycin resistance is used for selection in eukaryotic cells. The use of the EBV origin of replication and hygromycin resistance are important features for studies of PKDl transformed cell lines, since as a function of the transformation procedure they already contain SV40 large T antigen, and are G418 resistant. A. In vitro Expression The T7 promoter feature of pcDNA3 was used to analyze the protein product encoded by the PKDl cDNA employing the TNT Coupled Reticulocyte Lysate System, (Promega, Madison, WI) . This system enables large amounts of RNA to be synthesized from the T7 promoter, and the RNA to be translated into protein in the rabbit reticulocyte lysate. Since conventional molecular weight standards only extend up to -216 kD, the size estimates of in vi tro synthesized polycystin, -462 kD (non-glycosylated) , would be speculative at best. For this reason, a series of 3' deleted PKDl cDNA plasmid templates encoding truncated proteins of predicted size were constructed (Figure 10) . The protein products of these deletion clones as well as the full-length PKDl cDNA were analyzed using the TNT system. Newly synthesized protein was labeled by inclusion of radioactive amino acids, initially 35 S-methionine. The synthesized proteins were then resolved by electrophoresis on a 3-12% gradient SDS-PAGE gel. The mobility of the protein product produced from each of the truncated clones was consistent with its predicted molecular size. These results are consistent with assembled PKDl cDNA expression vectors directing in vitro synthesis of polycystin. B. In vivo Expression: PKDl cDNA Transfection in Human Embryonic Kidney (HEK) 293 cells cDNA constructs containing full-length PKDl cDNA or portions thereof were transfected into HEK 293 cells and assayed for PKDl expression using Northern analysis, 48 hours post-transfection. An insertless vector, pcDNA3, was used in parallel as a control for transfection. A Northern blot was probed with a PKDl-specific probe and then subsequently re-probed with a β-actin cDNA to normalize the respective lanes. The results showed that the PKDl mRNA is increased at least two-fold in HEK 293 which received the PKDl cDNA construct. Example 5: Diagnostic Tests for PKDl Mutations Whole blood samples collected in high glucose ACD Vacutainers™ (yellow top) were centrifuged and the buffy coat collected. The white cells were lysed with two washed of a 10:1 (v/v) mixture of 14mM NH 4 C1 and ImM NaHC0 3 their nuclei were resuspended in nuclei-lysis buffer (lOmM Tris, pH 8.0, 0.4M NaCl, 2mM EDTA, 0.5% SDS, 500 μg/ml proteinase K) and incubated overnight at 37°C. Samples were then extracted with a one-fourth volume of saturated NaCl and the DNA was precipitated in ethanol. The DNA was then washed with 70% ethanol, dried, and dissolved in TE buffer (lOmM Tris-HCl, pH 7.5, ImM EDTA) . A. Test I Long PCR conditions were used with a 4-part reaction mixture. Part 1 containing the following components: 3.3X XL Buffer 12 μl dNTPs (2mM each) 8 μl Forward primer (20μM) 1-5 μl Reverse primer (20μM) 1-5 μl Blocking oligo (2mM) 1.5 μl Mg(OAc)2, (25mM) 4.4 μl water to 40 μl Part 1 can be assembled as a single reaction component or in batch (10, 50, 100 reaction equivalents) and then dispensed as 40μl aliquots into individual reaction tubes. Part 2 comprises carefully adding 1 AmpliWaxPCR Gem 100 (or comparable product to each Part 1 reaction tube) . The tubes were incubated at 75-80°C for 5 min.to melt the wax bead. The reactions were cooled allowing the wax to solidify. In Part 3, the following components were added to the cooled reaction mixture of Part 2: 3.3X XL Buffer 18μl rTth DNA Polymerase, XL 2μl In Part 4, the following components are added to the reaction mixture of Part 3 : human DNA 0.2-lμg water to 40μl The forward primer used in the reaction described above comprises an oligonucleotide that hybridizes to both authentic PKDl and PKDl homologue sequences. An example of such a primer is: 5' -CACGACCTGTCCCAGGCAT-3 " (SEQ ID NO:6) (corresponding to nucleotides 4702-4720 of SEQ ID NO:l). The reverse primer comprises a sequence derived from a 3' region of the authentic PKDl gene, which may or may not be present in the PKDl homologues. Examples of such 3 ' regions and corresponding reverse primers are: 3 ' sequence: reverse primer: 5 ' -CTGGCGGGCGAGGAGAT-3 ' 5 ' -ATCTCCTCGCCCGCCAG-3 ' (SEQ ID NO:7) (SEQ ID NO:56) 5'-CTTTGACAAGCACATCT-3 ' 5 ' -AGATGTGCTTGTCAAAG-3 ' (SEQ ID NO:8) (SEQ ID NO:57) 5' -CAACTGGCTGGACAACA-3 • 5'-TGTTGTCCAGCCAGTTG-3 ' (SEQ ID NO:9) (SEQ ID NO:58) The blocking oligonucleotide comprises: 5'-AGGACCTGTCCAGGCATC-3 ' (SEQ ID NO:10). Importantly, this oligonucleotide must be incapable of supporting polymerization. One example is an oligonucleotide in which the 3 ' terminal nucleotide comprises a dideoxynucleotide. It will be understood that any modification that achieves this effect may be used in practicing the invention. Under appropriate conditions, the blocking oligonucleotide hybridizes efficiently to PKDl homologues but inefficiently to the authentic PKDl sequence. Thus, the amplification products in this diagnostic test are derived only from the authentic PKDl gene. Twenty-five to thirty-eight cycles of amplification were performed, using a standard DNA thermal cycler the following primer-dependent conditions for each cycle: SEQ ID NO:56: 94°C, 30 seconds; 62°C, 30 seconds; and 72°C, 34 minutes. SEQ ID NO:57: 94°C, 30 seconds; 56°C, 30 seconds; and 72°C, 37 minutes. SEQ ID NO:58: 94°C, 30 seconds; 58°C, 30 seconds; and 72°C, 45 minutes. The 72°C extension cycle was lengthened 5 seconds each subsequent cycle. The primary PCR product can be analyzed immediately for mutations or alternatively, can be used as a template for secondary PCR using a collection of paired amplimers to generate an overlapping set of smaller amplicons. The smaller amplicons can then be analyzed for mutations. B. Test II Long PCR conditions were used with a 4-part reaction mixture. Part 1 containing the following components: 3.3X XL Buffer 12 μl dNTPs (2mM each) 8 μl Forward primer (20μM) 1-5 μl Reverse primer (20μM) 1-5 μl Mg(OAc)2, (25mM) 4.4 μl water to 40 μl Part 1 can be assembled as a single reaction component or in batch (10, 50, 100 reaction equivalents) and then dispensed as 40μl aliquots into individual reaction tubes. Part- 2 comprises carefully adding 1 AmpliWaxPCR Gem 100 (or comparable product to each Part 1 reaction tube. The tubes were incubated at 75-80°C for 5 min. To melt the wax bead. The reactions were cooled allowing the wax to solidify. In Part 3, the following components were added to the cooled reaction mixture of Part 2: 3.3X XL Buffer 18μl rTth DNA Polymerase, XL 2μl In Part 4, the following components are added to the reaction mixture of Part 3: human DNA 0.2-lμg water to 40μl Twenty-five to thirty-eight cycles of amplification were performed, using a standard DNA thermal cycler the following protocol for each cycle: 94°C, 30 seconds; 61°C, 30 seconds; and 72°C, 11 minutes. The 72°C extension cycle was lengthened 5 seconds each subsequent cycle. The primary PCR product can be analyzed immediately for mutations or alternatively, can be used as a template for secondary PCR using a collection of paired amplimers to generate an overlapping set of smaller amplicons. The smaller amplicons can then be analyzed for mutations. The forward primer used in the reaction described above comprises an oligonucleotide that hybridizes to both authentic PKDl and PKDl homologue sequences. An Example of such a primer is: 5'- CTGCACTGACCTCACGCATGT -3' (SEQ ID NO:11) The reverse primer comprises a sequence derived from the authentic PKDl gene and is not present in the PKDl homologues. Thus, the amplification product in this diagnostic test is derived only from the authentic PKDl gene. An example of a suitable reverse primer is: 5'-GCGCTTTGCAGACGGTAGGCG -3' (SEQ ID NO:14) C. Test III Long PCR conditions were used with a 4-part reaction mixture. Part 1 containing the following components: 3.3X XL Buffer 12 μl dNTPs (2mM each) 8 μl Forward primer (20μM) 1-5 μl Reverse primer (20μM) 1-5 μl Mg(OAc)2, (25mM) 4.4 μl water to 40 μl Part 1 can be assembled as a single reaction component or in batch (10, 50, 100 reaction equivalents) and then dispensed as 40μl aliquots into individual reaction tubes. Part 2 comprises carefully adding 1 AmpliWaxPCR Gem 100 (or comparable product to each Part 1 reaction tube. The tubes were incubated at 75-80°C for 5 min. To melt the wax bead. The reactions were cooled allowing the wax to solidify. In Part 3, the following components were added to the cooled reaction mixture of Part 2: 3.3X XL Buffer 18μl rTth DNA Polymerase, XL 2μl In Part 4, the following components are added to the reaction mixture of Part 3 : human DNA 0.2-lμg water to 40 μl Twenty-five to thirty-eight cycles of amplification were performed, using a standard DNA thermal cycler the following protocol for each cycle: 94°C, 30 seconds; 65°C, 30 seconds; and 72°C, 11 minutes. The 72°C extension cycle was lengthened 5 seconds each subsequent cycle. The primary PCR product can be analyzed immediately for mutations or alternatively, can be used as a template for secondary PCR using a collection of paired amplimers to generate an overlapping set of smaller amplicons. The smaller amplicons can then be analyzed for mutations. The forward primer used in the reaction described above comprises an oligonucleotide that hybridizes to both authentic PKDl and PKDl homologue sequences. An Example of such a primer is: 5'- ACGTTGGGCTCCTGGGCAACC -3' (SEQ ID NO:12) The reverse primer comprises a sequence derived from the authentic PKDl gene and is not present in the PKDl homologues. Thus, the amplification product in this diagnostic test is derived only from the authentic PKDl gene. An example of a suitable reverse primer is: 5'-AGGTCAACGTGGGCCTCCAAGTAGT -3' (SEQ ID NO:13) For RT-PCR, first strand cDNA synthesis is performed using the reverse primer (SEQ ID NO:14) and Superscriptll™ according to manufacturer's recommended conditions (Life Technologies, Inc., Gaithersburg, MD) . PCR is then performed using 1-50% of the first strand reaction under the reaction conditions described above, with the modification that the extension cycle is conducted at 72°C for only 6 min. (due to the smaller product size) . D . Test IV To analyze PKDl mRNA for mutations, RNA is isolated from the white blood cells as a requisite template for RT- PCR. Whole blood samples collected in high glucose ACD Vacutainers™ (yellow top) were centrifuged and the buffy coat collected (4-20 x 10 6 cells/10 ml of blood) . RNA can be isolated directly from white blood cells or after standard short-term culturing of white blood cells in the presence of a mitogen such as phytohemagglutinin (48-72 hours) . RNA is isolated as described using standard conditions such as guanidium isothiocyanate:acid phenol extraction (Chomczynski and Sacchi, Anal . Biochem . 162:156-159, 1987). For RT-PCR, first strand cDNA synthesis is performed using the reverse primer (below) and a commercially available reverse transcriptase, such as, for example, Superscriptll™ according to manufacturer's recommended conditions (Life Technologies, Inc., Gaithersburg, MD) . PCR is then performed using 1-50% of the first strand reaction under the reaction conditions described below. The reverse primer comprises a sequence derived from both the authentic PKDl gene and the PKDl homologues. In contrast, the forward primer is specific for the authentic PKDl locus and will not allow amplification of cDNAs derived from the homologous loci. Thus, the resulting RT-PCR amplification product in this diagnostic test is derived only from authentic PKDl RNA. The forward primer used in this reaction comprises an oligonucleotide that hybridizes only to authentic PKDl and not to homologue sequences. An example of such a primer is: 5'- AGCGCAACTACTTGGAGGCCC -3' (SEQ ID NO:15) An example of a suitable reverse primer is: 5'- GCCAAAGGGAAAGGGATTGGA -3' (SEQ ID NO:16) The amplification aspect of the RT-PCR reactions was performed using standard conditions as described below including a "hot-start" step: 10X Taq Buffer 8 μl dNTPs (2mM each) 7 μl Forward Primer (100μM) 0.4-1.5 μl Reverse Primer (100μM) 0.4-1.5 μl DNA 0.2-1.0 μg water to 80 μl Amplification was initiated using a single "hot- start" step, followed by twenty-five to thirty-eight cycles of amplification using a standard DNA thermal cycler. The single "hot-start" step consisted of 80°C for 3-5 minutes after which time lμl of Taq polymerase was added to each reaction tube. "Hot-start" was proceeded by 25-38 cycles with each cycle consisting of the following specifications: 94°C, 20 seconds; 64°C, 30 seconds; and 72°C, 2 minutes. The primary PCR product can be analyzed immediately for mutations or alternatively, can be used as a template for secondary PCR using a collection of paired amplimers to generate an overlapping set of smaller amplicons. The smaller amplicons can then be analyzed for mutations. The PCR and RT-PCR products obtained above were analyzed for the presence of specific PKDl mutations as follows: 8 μl of the amplified products were added to 50 μl of a denaturing solution (0.5mM NaOH, 2.0M NaCl, 25mM EDTA) and spotted onto nylon membrane filters (INC Biotrans) . The denatured DNA was then fixed to the nylon filters by baking the filters at 80°C for 15 minutes under vacuum. Oligonucleotides that detect PKDl mutations were chemically synthesized using an automated synthesizer and radiolabeled with ψ 2 P with polynucleotide kinase, using methods that are standard in the art. Hybridizations were carried out in plastic bags containing the filters prepared above, to which one or more labeled oligonucleotides were added in a hybridization buffer (3.0M Tetramethylammonium chloride (TMAC), 0.6% SDS, ImM EDTA, lOmM sodium phosphate pH 6.8, 5X Denhardt's Solution, and 40 μg/ml yeast RNA) . Oligonucleotide concentrations in the pools ranged from 0.03 to 0.15 pmol/ml hybridization solution. Hybridizations were allowed to proceed overnight at 52°C, with agitation. The filters were then removed from the bags and washed for 20 min. at room temperature with wash buffer (3.0M TMAC, 0.6% SDS, ImM EDTA, lOmM sodium phosphate pH 6.8), followed by a second wash in the same buffer for 20 min. at 52°C. The filters were dried and exposed to Kodak X-OMAT™ film. It will be understood that the enzymes and nucleotides used in the above reactions may be obtained from any manufacturer, such as GIBCO-BRL, Promega, New England Biolabs, and the like. Example 6: Antipolvcvstin Antibodies A. Production and Characterization of Polyclonal Antisera Against Synthetic C-Terminal Peptide. A peptide (C)SRTPLRAKNKVHPSST (SEQ ID NO:17) representing the last 16 carboxy-terminal amino acids of the predicted PKDl gene product was synthesized. A cysteine residue that is not predicted from the DNA sequence was appended to the amino terminus to facilitate coupling to KLH carrier protein. Two rabbits (A and B) were immunized with the peptide as described in Cheng et al. , EMBO J. 7:3845- 3855, 1988. Polyclonal anti-peptide antisera were diluted from 1:10 up to 1:10,000, and immunoreactivity was determined by ELISA according to conventional procedures (Cheng et al., EMBO J. , 1988 supra . ) . Antisera produced by both rabbits were epitope mapped by the SPOTs method (Blankenmeyer-Menge and Frank, in INNOVATION AND PERSPECTIVES IN SOLID PHASE SYNTHESIS, Epton, R. Ed., Chapman and Hall Medical, London, 1990, pp. 1-10) . Briefly, overlapping 8 amino acid long peptides were synthesized simultaneously on a cellulose membrane and assayed for immunological reactivity. Positive peptides were aligned and the epitope was identified by determining sequence homologies. Interestingly, antisera A and B had at least 2 non-overlapping epitopes each, thus increasing the possibility that these antibodies will recognize the PKDl gene product. B. Domain Specific Fusion Proteins Four fusion clones were constructed to contain different domains of polycystin such that the correct open reading frame was maintained, as shown in Figure 15. Three of the expression constructs were cloned in the pGEX vectors designed for the expression of foreign sequences as glutathione S-transferase (GST) fusion proteins in E. coli . These are FP-LRR, which contained the leucine-rich repeat (LRR) ; FP-46-lc, containing 83 C-terminal amino acids and FP46-2 which has 77 amino acids internal to the FP-46-lc. The fourth fusion construct was cloned into a maltose binding protein (MBP) vector, and encoded 205 amino acids at the carboxy terminus, thus overlapping two of the GST fusion proteins. The overlapping carboxy-fusion products provide an additional layer of antibody reagent confirmation. They allow one to verify that positive antibody reactions are not artifactual, since similar, if not identical, patterns of antibody reactivity should be seen with antibodies raised against these overlapping proteins. Two different 'carrier' fusion proteins also allows one to purify antibody raised against a fusion product using the alternate carrier protein as the affinity ligand. This helps to eliminate antibodies raised against the carrier protein itself. GST fusion proteins were purified from extracts of transformed bacteria using glutathione-Sepharose (Pharmacia) as described in Smith and Johnson, Gene 67:31-40, 1988. MBP fusion proteins were purified on amylose resin (NEB, Beverly, MA) . C. Generation and characterization of polyclonal antibodies to domain specific polycystin fusion proteins. Antibodies against the fusion proteins were raised in rabbits using published procedures (Cheng et al., EMBO J. 1988 supra . ) with 200 μg of protein. These respective antibodies specifically recognized PKDl protein as part of the fusion protein construct used as immunogen (i.e., FP-LRR, FP46-1C, FP46-2 and MAL-BD-3) . Further, these antibodies did not bind the irrelevant antigens GST or MBP, nor cross-react to polycystin domains not present in the immunogen included as controls after sufficient antibody purification. In vi tro synthesized polycystin protein was used to test the domain specific antibodies. In addition to the full-length PKDl cDNA, two shorter clones which each expressed only a subset of the PKDl domains were constructed in expression vectors as shown in Figure 16. The BRASH 7 clone contains the carboxy terminal epitopes, as well as the transmembrane domains, while SrflΔ contains the amino terminus, the LRR, and the majority of the Ig-like domains. Both are efficiently expressed in the TNT in vitro transcription/translation system. D. Immunoprecipitation Antipolycystin antibodies were incubated with either protein A Sepharose or Protein G Sepharose to generate antibody coupled beads. These beads were then incubated with 35 S-labeled protein synthesized in vi tro from the expression clones. The void and retained fractions were collected and analyzed by SDS gel electrophoresis. Sepharose alone was included as a control against artifactual binding, a concern due to the large size of polycystin, the presence of the large number of Ig-like repeats, and the lectin domain. Antibodies to irrelevant antigens were also included as controls. If the antibody specifically bound the antigen, a protein species of the correct molecular mass will be detected on the gel in the bead fraction. If not, the expressed protein will appear in the void volume on the gel. Each of the anti-fusion protein antibodies coupled to Sepharose A specifically immunoprecipitated protein expressed by clones which contained the matching antigenic domain. The antibodies did not immunoprecipitate protein expressed from irrelevant domains of polycystin (i.e. domains not used as immunogen to generate that particular antibody) , nor did they recognize other irrelevant antigens (e.g., luciferase) . These results confirm that these polyclonal antibodies specifically recognize the carboxy terminus and LRR domains of polycystin. Example 7: Identification of Proteins that Interact with PKDl Further characterization of the PKDl protein can be accomplished through identification of other proteins which normally interact with the PKDl protein. Those of skill in the art are familiar with a variety of approaches useful for such purposes, including, but not limited to, immunoprecipitation of protein complexes using antipolycystin antibodies, screening of expression libraries with labeled in vi tro synthesized polycystin, and use of yeast systems that exploit the interaction of DNA binding and activation domains. For example, one such approach is the two-hybrid yeast system (Fields and Song, Nature 340:245-6, 1989; Finley and Brent, Proc. Natl . Acad. Sci . , USA 91:12980-84, 1994) which enables the identification of genes which encode proteins that interact with PKDl. This technique relies on the fact that eukaryotic transcriptional activators, such as GAL4, function utilizing two essential and discrete domains, i.e., an amino terminal DNA binding domain and a carboxy terminal transcriptional activation domain (Ma and Ptashne, Cell 51:113-119, 1987). The two-hybrid system exploits the observation that a functional transcriptional activator can be generated even when the two domains are encoded by different hybrid polypeptides, so long as the spatial relationship between the two essential domains is similar to the native transcriptional activator. The yeast two hybrid system has been used successfully to screen cDNA expression libraries in search of proteins that interact with Yin-Yang-1 (Shrivastava et al., Science 262:1889-92, 1993), E12 (Staudinger et al., J. Biol . Chem. 268:4608-11, 1993), H-Ras (Vojtek et al., Cell 74.-205-214, 1993), Pr55gag (Luban et al., Cell 73:1067-78, 1993), pllORB (Durfee et al. , Genes Dev. 7:555-69, 1993), and p53 (Iwabuchi et al., Oncogene 8:1693-96, 1993). A. Hybrid Construction Several constructs of the PKDl regions as fusion proteins with the GAL4 DNA binding domain were prepared. The constructs were: a BD-3 fusion between the GAL4 DNA-binding domain and the cytoplasmic tail of the PKDl protein (amino acid residues 4097-4302) using pGBT9 vector, a BD-1 clone containing a DNA-binding domain and the LRR region of polycystin (amino acid residues 27-360) , and a BD-2 clone which contains DNA-binding domain and region of Ig-like repeats (amino acid residues 713-2324) . B. Transformation of constructs into yeast Competent yeast cells HF7c, containing the lacZ reporter gene are obtained by the LiAc method. Briefly, overnight cultures are diluted to OD600 = 0.2 and continue to grow for an additional 3 hr. Cells are collected, washed in H 2 0 and resuspended in 0.IM LiAc in TE. Competent cells (0.1 ml) are mixed with 0.1 mg of plasmid-construct DNA and 100 mg of carrier DNA. 50% PEG400 (0.6 ml) is added and incubated at 30°C for lh. Following this incubation, the cells are heated to 42°C for 10 min. and plated on minimal medium (Difco Yeast Nitrogen Base without amino acids, supplemented with auxotrophic requirements) . Yeast transformants are selected after 3 days of culture. B. Colony lift filter assay for β-galactosidase VWR grade 410 filters are layered over agar plates containing transformants on selection medium and transferred to a pool of liquid nitrogen for 10 sec. Filters, colony side up are placed on another filter that is presoaked in X-gal solution. After two hours, filters are analyzed for the presence of blue, β-galactosidase producing colonies (not shown) . Alternatively, individual colonies from different transformations can be streaked onto the same plate and processed for β-galactosidase activity. While the present invention has been described with respect to what are presently considered to be the preferred embodiments, it is to be understood that the invention is not limited to the disclosed embodiments. To the contrary, the invention is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims. The scope of the following claims is to be accorded the broadest interpretation so as to encompass all such modifications and equivalent structures and functions. SEQUENCE LISTING (1) GENERAL INFORMATION: (i) APPLICANT: KLINGER, KATHERINE W LANDES, GREGORY M BURN, TIMOTHY C CONNORS, TIMOTHY D DACKOWSKI, WILLIAM GERMINO, GREGORY QIAN, FENG (ii) TITLE OF INVENTION: POLYCYSTIC KIDNEY DISEASE GENE (iii) NUMBER OF SEQUENCES: 58 (iv) CORRESPONDENCE ADDRESS: (A) ADDRESSEE: GENZYME CORPORATION (B) STREET: ONE MOUNTAIN ROAD (C) CITY: FRAMINGHAM (D) STATE: MASSACHUSETTS (E) COUNTRY: USA (F) ZIP: 01701 (v) COMPUTER READABLE FORM: (A) MEDIUM TYPE: Floppy disk (B) COMPUTER: IBM PC compatible (C) OPERATING SYSTEM: PC-DOS/MS-DOS (D) SOFTWARE: Patentln Release #1.0, Version #1.25 (vi) CURRENT APPLICATION DATA: (A) APPLICATION NUMBER: US (B) FILING DATE: (C) CLASSIFICATION: (viii) ATTORNEY/AGENT INFORMATION: (A) NAME: LASSEN, ELIZABETH (B) REGISTRATION NUMBER: 31,845 (C) REFERENCE/DOCKET NUMBER: GEN4-17.8 (ix) TELECOMMUNICATION INFORMATION: (A) TELEPHONE: 508-872-8400 (B) TELEFAX: 508-872-5415 (2) INFORMATION FOR SEQ ID NO:l: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 53577 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l: TGTAAACTTT TTGAGACAGC ATCTCACCCT GTTCCCCAGG CTGGAGTGCΛ GTGGTGTGAT 60 CATGGCTCAC TGCAGCGTCA ACCTCCTGGG TCTACTTGAT CTGTAAACTT CGAGGGAAGG 120 TGTAATAAAC CCTCCTGCAA TGTCTTTGTT TTTCAAAATC TTTGTATTTC ACAGTTTAGC 180 TTCGTGGGTT GATGTTCTAT TTTGTTTTTG TGTGTGTGTG TGTGTGTTTT GTGTTTTTTT 240 TTGAGACACA GTCTTGCTCT TGTTGCCCAG GCTGGAGTGC AATGGTGTGA TCTTGGCTCA 300 CTGCAACTTC CACCTCTTGG GTTCAAGAGA TTCTCCTGCC TCAGCCTTCC GAGTAGCTAG 360 GATTACAGGC GCCGCCACCA CACCCCGCTA ATTTTGTATT TTTAGTAGAG ATGGGGTTTC 420 TCCATATTGG TCAGGCTGGT CTCAAACTCC CGACCTCAGG TGATCCGCCC ACCTCAGCCT 480 CCCAAAATGC TGGGATTACA GGCGTGAGTC ACCGCACCTG GCCAATGTTC TATTTTTGAG 540 AACACAACAG TTCATAATAT ATTCTACATA GACCATACCT GTTATGTGTA GATAAACAGA 600 CTCTTTTCCC ATTTAACACC TTTTGCCTTA GGTTTATTTT TCTGGTATCA ATACTGGCAC 660 ACTTACTTTG TTTGCAGTTT CCTGTCTTTT TTTTTTTTTT TTTTTTTTTT GAGACAGAGT 720 CTCACTCTGT CACCCAGGCT GGAGTGAAGT GGCGGGATCT CGGCTCACTG CAACCTCTAC 780 CTCCTGGGTT CATGCGATTC TCCTGCCTCA GCTTCCCGAA TAGCTGAGAC CACAACTGTG 840 TGCCACCATG CCCAGCCAAT TTTTGTATTT TTAGTAGACA CGGGGTTTCA CCATACTGGC 900 CAGGATGGCT CAATCTCTTG ACCTCGTGAT CCACCTGCCT CCGCCTCCCA AAGTGCTGGG 960 ATTACAGGCA TGAGCCACTG TGCCTGGCCT TTTTTTTTCT TTTTGAGATG GAGTCTCACT 1020 CTGTCACCCA GGCTGGAGTG CAGTGGGGTA ACCTCAGGTC ACTGCGACCT CCGCCTCCCG 1080 GGTTCCAGTG ATTCTCCTGC CTCAGCCTCC CGAGTAGCTG GGATTACAGG CACCCACCAC 1140 CATGCCTGGC TAATTTTTGT ATTTTTAGTA GAGACGGGGT TTTGCCACGT TGGCCAGGTT 1200 GGTCTCGAAC TCTTGGCCTC ATGTGACCCG CCTGCCTTGG CCTCCCAAAG TGCTGGGATT 1260 ACAGGTGTGA GCCACTGTGC CTGGCCTGGC TTTCTTGTTT CTTTTCTCCT CTTCTAGTTT 1320 CCCCCTTTTA GGCTAACAAT TATTCACTGT TAATAAAAAC CCTCAGGTCT GTATTTTATC 1380 AAGAAACATT TCCCTCACGT CTTCTTCCCT GAACCAAACA AGATCTCTGG CACATTTTAT 1440 TTGCTCTGTC TCACCACATG GATTTTGTTT TTTTGTTTCT TTGTTTTTTG AGATGGAGTC 1500 TCACTCTTGT TGCCCAGGCT GGAGTGCCAT GGCACAATCT CAGCTCACTG CAACCTCCAC 1560 CTCCTGGGTT CAAGCGATTC TCCTGTCTCA GCCTCCTGAG TAGCTGGGAT TACAGGCGCG 1620 TGGCACCACC CCCAGCTAAT TTTTGTATTT TTAGTAGAGA CGGGGTTTCA CCATGTTGGT 1680 CAGGCTGGTC TCGAACTCCT GACCTTGTGA TCTGCCCACC TTGGCCTCCC AAAGTGCTGG 1740 GATTACAGGC ATGAGCCACC ACGCCCGGCC CCCATGGTTT TTCAAATAGT TTAGAATTTC 1800 ATTTCCAGGT AACTAATTTG CTTCTTTAAA CATATGTCTT TTCTATTTAA GAAATCCTTT 1860 CTAAACAATT GCATTTTATT CCACAACCGC CTTCAAACAA TCATTGAGAC TTGGTTAATC 1920 TGTTTTGCTC ATTTGGCAGC AGTTTCTTGT GGCTGTTTCT TCCCTCCACT GGAGTCCTTG 1980 AATCTTAAGT CTGTCATTTG ACTGCAATTA AAAGCTGGGT TTGGAATACA ATCGCAGCCT 2040 TACCATCCAC CTGCTGTGTG ACCTGGTAAA TTTCTTTTTT TTTTTTTGAG ACGGAGTCTT 2100 GCTCTGTTGC CCAGGCTGGA GTGCAGTGGC ACAACCTCTG CCTCCCAGGT TCAAGCGATT 2160 CTACTGCCTC AGGCTCCCTA GTAGCTGGGA TTATAGGTGC CTGCCACCAT GCCCAGCTGA 2220 TTTTTGTATT TTTAGTAGAG ATGAGGTTTC ACCATGTTGG CTAGGCTGGT CTCGAACTTC 2280 TGATCTTGTG ATCTGCCCGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG CATGAGCCAC 2340 CACTCCCAGC CAGTTCTTTT TTTCTTTTTT CCATTTTTTT TTTTTTCGAG ACAGGATCTT 2400 ACTCTTTTGC CCAGGCGGGA GTGCAGTGGC ACAATCACGG CTCAGCGCAG CCACTGCCTA 2460 CTGGGCTCAC ACGCTCCTCC GGCCTCAGCC TCTCGAGTAC CTGGGACTAC AAGCGTGAGC 2520 CAGTTTGGCT AATTTTGGCT AATTTTTGTA GAAACGGGGT CTCGCCATGT TGGCCAGGCT 2580 GGTCTCCAAC TCCTGGACTC AAGGGATCCA CCTTCCTCCC CCTCTCAAAG TTCTGGGATT 2640 ACCGGAGTGA GCCACTGTGC CCTGCTGGCA AATTTCTTAA ACTGTCTGTG CCTCAGTGAC 2700 CTCATTTAAT AAAGGGAATA ATTGTAGCAC ACTTTTTCTA GAGCTGTGAA GATTCAATGG 2760 AATAAATAAG GCAATAAATG AATGGATGGG GAATGAAGGA TGTGGGTTTC CTCCCTCTTG 2820 TCTTTCAATA AGCTCTCACC ATCAACCTCC CATTGCCTGT TCTCTCTCTT CCCCCTCTCT 2880 CCCTCTGTCT CTCTCTCAGC CAGGAAACCT GGGGTAGGGA GGCTTGGAGC CAGCGGGTGC 2940 GTCGGGAGGC TGCGGGTACT GACTCGGGCC GCGCACGGAG ATCGCGGGAG AAGGATCCAC 3000 AACCGCGGAA GAAGGATCAG GGTGGAGCCT GTGGCTGCTG CAGGAGGAGG AACCCGCCGC 3060 CTGGCCCACA CCACAGGAGA AGGGCGGAGC AGATGGCACC CTGCCCACCG CTTCCCGCCC 3120 ACGCACTTTA GCCTGCAGCG GGGCGGAGCG TGAAAAATAG CTCGTGCTCC TCGGCCGACT 3180 CTGCAGTGCG ACGGCGGTGC TTCCAGACGC TCCGCCCCAC GTCGCATGCG CCCCGGGAAC 3240 GCGTGGGGCG GAGCTTCCGG AGGCCCCGCC CTGCTGCCGA CCCTGTGGAG CGGAGGGTGA 3300 AGCCTCCGGA TGCCAGTCCC TCATCGCTGG CCCGGTCGCG CTGTGGCGAA GGGGGCGGAG 3360 CCTGCACCCG CCCCGCCCCC CCTCGCCCCG TCCGCCCCGC GCCGCGCGGG GAGGAGGAGG 3420 AGGAGCCGCG GCGGGGCCCG CACTGCAGCG CCAGCGTCCG AGCGGGCGGC CGAGCTCCCG 3480 GAGCGGCCTG GCCCCGAGCC CCGAGCGGGC GTCGCTCAGC AGCAGGTCGC GGCCGCAGCC 3540 CCATCCAGCC CGCGCCCGCC ATGCCGTCCG CGGGCCCCGC CTGAGCTGCG GCCTCCGCGC 3600 GCGGGCGGGC CTGGGGACGG CGGGGCCATG CGCGCGCTGC CCTAACGATG CCGCCCGCCG 3660 CGCCCGCCCG CCTGGCGCTG GCCCTGGGCC TGGGCCTGTG GCTCGGGGCG CTGGCGGGGG 3720 GCCCCGGGCG CGGCTGCGGG CCCTGCGAGC CCCCCTGCCT CTGCGGCCCA GCGCCCGGCG 3780 CCGCCTGCCG CGTCAACTGC TCGGGCCGCG GGCTGCGGAC GCTCGGTCCC GCGCTGCGCA 3840 TCCCCGCGGA CGCCACAGCG CTGTGAGTAG CGGGCCCAGC GGCACCCGGG AGAGGCCGCG 3900 GGACGGGCGG GCGTGGGCGG GTTCCCTGGC CCGGGACGGG AAGCAGGACG CGGGCCAGGA 3960 CGCTCCCAGG GGCGAGGCTC CGGCGCGGCA CGGCGGGCCC TGCTAAATAA GGAACGCCTG 4020 GAGCCGCGGT TGGCACGGCC CCGGGGAGCC GAAAAACCCC GGGTCTGGAG ACAGACGTCC 4080 CACCCGGGGG CTCTGCAGAC GCCAGCGGGG GCGGGGCGCG GAGGCCGCGC TCAGCTGGGA 4140 GGACAAACAG TCGCTAATTG GAGAGGAATT GGGATCGGCC TGGGGCTGCG GGGTACCCGG 4200 AGAGGTGGGG ATGGCTGTAG GGGGCGGCAG GGAAGAGTTC CAGGAGGTGT CTGGAAAAGG 4260 ATTTGATGGA TGTGCAAGAA TTGGGCTGAT GCTTAGGAAG GGGCGATGAG GTGGGTCCAG 4320 AAGAAGGGGG GTGAACGGTG TGAGCAAAGA CCGTGAGGCT GGAGGCTGGC CACGGGAGGT 4380 GTGAGGGGTA GGGGCAGGGT GGGAGGTGGG CTCGCGGGTG GGCTGGGGTC ATGAAGGGCC 4440 TCAGGCGCTC TGCTATTGGG TTCCAAGGCT ATCCTGAGAA CAGGGGTGAG GGGGGATTGC 4500 CGTGGGGGGT TAAAGCCTTG TCATGTTCGC TTTCGGGAGA TAAAAACAAC AGGTGGCCTT 4560 TATGGAGACG CTGCCCAGAG CCAGGTCTGT GCCAGGCTCC TGTTGGGGGT CGTCATGCGG 4620 AATCCTGACT CTGACCATCC GAGGCATAGG GACCGTGGAG ATTTGCATTT CACAGATGAG 4680 GAAACAGGTT TGGAGAGGTG ACACGACCTG TCCCAGGCAT CACAGCCGGG ATGTGCATAG 4740 CAGGGGTTTG GAACTATGAG GTGCCCAGGA CCCAGGGTTG GATTGAAAAG GGCGGAGGGG 4800 ACTAAGATAA GCAGACAGTT GTCCCCAGCG CTGGGGAGAG TCTTGGGACC AGTCTGATGC 4860 CTTGTATTTC CCAGGCTCCA GGCTCCTCGC CGGGACAGTG TCTCCTTGGG TGCGTGCTGG 4920 ATCCCTGGGG GACGTGGCAC ATCCCCAGGC TTGCTAAACA TTGGGTGGGT TCTGGCATTT 4980 GGTTTTGTAA CGTTTCTGGG TCACTCCCGC CTGTGGCCAC CCTTCCTTAG GGGAGCCGTG 5040 TGTCCTTGGG GCTTTGCTGG GTGGTCTCGA GGGTGGGAGA AGAATGGGTT CTCCTGGACC 5100 AATGGAGCCC GTGCCCCTCG GGGCCACATT GCTCCTGCGC TCCCTGACTG CGGACGCGTG 5160 TGTCTCGCGG CTGTCTCTGT GGAGATGGCC TCCTCCTGCC TGGCAACAGC ACCCACAGAA 5220 TTGCATCAGA CCTACCCCAC CCGTTGTTTG TGATGCTGTA GCTGAGGGCT CCTCTGTCTG 5280 CCAGGCCGGT CACTGGGGAC TCTGTCCAGG GCCTGGTGGT TCCTGCTTCC CAGCACCTGA 5340 TGGTGTCCAT GAGAGCAGCC CCTCAGGAGC TGTCCGGGAG AGAAGGGCGC TGGTGGCTGC 5400 TGAGCGGAGA GCAAGGCCCG TGTTCTCCAG GCCCTTGGCA CAGCAGTGGA GCCCCCGCCC 5460 CTGCCTTGTG TTGTCCTCTT AGGCTCTGGT CCTGGGGTTT GGAGGAGGGG GACCCTGGGA 5520 GTTGGTGGCC TGTCCCAGCC TGAGCTGGCA AGATTCCGAA TGCCAGGCCC CCCAAGTGTG 5580 CAACAGGGCA CAGGGTGACC TCATGTGGGC AGGTGGGTGC TGTTCTGTAC ACACCTGGGG 5640 CCGCCGCTGG GAGAGTTCTG GAAGGTGGGG TGAGGGGACC CATGGCAAAC TAGGGCCTTA 5700 GGAAGGATGT GAAGGCCCTG GCTGGCCCCC CAGGCCACCC TCTGTGCTGT GGGGCAGCCC 5760 AGCCATTTTG CTGTCTACCC TGCAAACTCC TCCTCGGGGA GACGGCTGGG TTTTCCCCAG 5820 GGAAGAGGGG TCAAGCTGGG AGAGGTGAAG GACACAGATC ACAGCTGCTG GCAGGTGTTC 5880 AAGGGTCCAA GAGCGTTGCT GTCTGGGTGT CACCAGTAGC CTTCCTGGGG GGCTCACGCA 5940 GGTGCCTCTC CACTTGTGGC TCCCTGGCTG CTGAAGCTCA GCAGGGACAG CTGTGTCCAG 6000 TTCCAGGTGG AGGACAGCCG GGGCTTCTGA GGCCACAGCC TGCCTTGGGT TAATGATGCT 6060 GCCGAGAGGT GGTGGCTTTT GGAAAAGATG GCGTACTGCA AAACGTGCTG CTCTGCGTGG 6120 CTCGAAGCTT CGTGGGGAGA CGTGGGCAGA GCCGTGGCTG ACTCACAGAC CCCCCACCCC 6180 AGAGCCTGCC CTGCCCTCCC TGCCCCGACC CTTCTCCCTC CTGACCCATG TGTTTTTTTT 6240 ττττττττττ TTTTTTGAGA CAGAGTTCAC TCTTGTTGCC AAGGCTGGAG TGCAATGGCA 6300 CGATCTCGGC TCATGGCAAC CTCCGCCTCC TGGGTTCAAG CGCTTTTTCC TGCCTCAGCC 6360 TCCCGAGTAG CTGGGATTAC AGGCGTGCAC CACCATGCCT GGCTAATTTT GTATTTTTAG 6420 TAGAGACAGG GTTTCTCCAT ATTGGTCAGG CTGGTCTTGA ACTCCTGACC TCAGATGATC 6480 CGCCCGCCTC GGCCTCCCAA AGTGCTGGGA TTACAGGCAT GAGCCACCAC GCCCAGCCCT 6540 GACCCATGTT TTGAACCAAA TTCCAGCCAC CCTTTTATCT GCAAGCATTT TGGAGGGCAT 6600 CGCAATACTG CAGACCCACC TAACACAACA GACAGTTCCT TCATGCCACC GAAGGCCTGG 6660 TGTGTTCACA TTTTTGGTTT AATAGTTTGA ATTAAGAGCC AAATAAGGTC CACACACTGC 6720 AATTAGTTGA TGTCTTTTTT TTTTTCTTTT TTTTTTTTTT TTTGAGACGG AGTCTTGCTC 6780 TTGTCTCCAG GCCGCAGTGC AGTGGCATGA TCTCAGCTCA CCGCAACCTC CGACTCCCTG 6840 GTTCAAGCGA TTCTCCTGCC TCAGCCTCCC GAGTACCTGG TAGCTGGGTT TACAGGCATG 6900 CACCACCGTG CCCAGCTAAT TTTTGTATTT TTAGTAGAGA CGGGGTTTTA CTGTGTTGGC 6960 CAGGATGGTC TCGATCTCCT GACCTCGTGA TCTGCCCACC TCGGCCTCCC AAAGTGCTGG 7020 GATTACAGGC GTGAGCCACC GCACCCGGCC AATGTCTTTT AAAAATATAT ACTTTTTTTT 7080 TTTTTTTGAG ACGGAGTTTC GCTCTTGTTG CCCAGGCTGG AGTGCAGTGG CGCGATCTCA 7140 CCTCACGGCA ACCTCCGCCT CCCGGGTTCA AGTGATTCTC CTGCCTCAGC CTCTCCAGTA 7200 GCTGGGATTA CAGGCATGTG CCACCATGCC TGGCTAATTT TGTATTTTTA GGAGAGACGG 7260 GGTTTCTCCA CGTTGGTCAG GCTGGTCTCA AACTCCTGAC CTCAGGTGAT CCGCCTGCCT 7320 TGGCCTCCCA AAGTGTTGGG ATTACAGGTG TGAGCCAACG CGCCCAGACA AAAATATATG 7380 TGTGTCTTTA AGGCTGGTCA AGCAAAGCAG TAGGACTGGA GAAAGAATGA AGAATTCTAC 7440 CTGGCTGTGA TCAATTCGTT GTGAACACCA CTGTGCTTGG ACCAGCTAGC TGATGTCTTT 7500 TGTTTTGTTT TGTTTGAGAC GGAGTCTGGC TCTGTCACCC AGGCTGGAGG ACAATGGTGT 7560 GATCTCGGCT CACTGCAGCC TCCATCTCCC GGGTTCAAGC GATTCTCCTG CCTCAGCCTC 7620 CTGAGTAGCT GGGATTAGAG GCGCGCGCCA CCACGCCCGG CTAATTTTTA AAAATATTTT 7680 TAGTAGAGAT GGGGTTTCAC CATGTTGGTC AGGCTGGTCT TGAACTCTTG GCCTTAGGTG 7740 ATCTGCTTGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG TGTGAGTGAT GTATTTTATT 7800 TATTTATTTA TTTATTTATT TTTATTATTT GAGATGGAGT CTCACTCTGT TGCCCAGGCT 7860 GGAGTGCAGC AGTGCCATCT CAGCTCACTG CAAGCTCCGC CTCCTGGGTT CACGCCATTC 7920 TCCTGCCTCA GCCTCCTGAG TAGCCTGGAC TGGTGCCCGC CACCATGCCC AGCTAATTTT 7980 TTGTATTTTT AGTAGAGACG GGGTTTCACC GTGTTAGCCA GGATGGTCTG GATCTCCTGA 8040 CCTCGTGATC CTCCCGCCTC AGCCTCCCAA AGTGCTGGGA TTACAGGCTT GAGCCACCGC 8100 CTGTCTTTTA AATGTCCGAT GATGTCTAGG AGCTTCCCTT CCTCTCTTTT TCCTTGTGCA 8160 ATTTGTTGAA GAAACTGGCT CCTGCAGCCT GGATTTCTCG CTGTGTCTTG GGGGTGCCAC 8220 CTCCATGGTG TCACCTCCGT GGTGCTGTGA GTGTGTGCTT TGTGTTTCTT GTAAATTGGT 8280 CGTTGGAGCC GACATCCCAT TGTCCCAGAG GTTGTCCTGG CTGGCACTGG CCTAGGTGTA 8340 GATGTCATCA GCTCAGGGCC CCCTGCTCTA AAGGCCACTT CTGGTGCTGG TTGCCACTCA 8400 CCCTGGCTGG GGGTCACCTG GGTCTGCTGC TGTCTCGCAA ATGCTGGGGT CCAGGACTGG 8460 GCACATCGAG GGACTTGGTA GGTGCTTGGT TCACTGATGT AAAATATAGG AGCACCCGGG 8520 GCCTTGCCCT TTCCCACCTG CATCCCTGAA TGACAGGAGA GTGTGGGAGA GTGTAGGGAC 8580 AGCAGGCGCA GACCCCGGGG CCCCTGCCTG GGATTGGCGT CGGGGAAGAC AGGCATTCTG 8640 GAGCGACCCC TAGGCCTGAT GCCTTAGAGC GCAACTGCCA GAGACACAGC TTCCTTGGGG 8700 GGCTGGCCAG GCCACGGAGG GGCCCTGGCT CCCATTTCTG GTCCCTGGAT CCTGAGAGCG 8760 AGGACTAGGG ATTGTCACCA AGGCCTCCAT GAGCCCTCAG CAGAAGGAGG GCCACCCTCG 8820 AGGGCTCCGT TATCACTGGA GCCCGCGTTC AACCAACACG CAGATGATTC TCCAAGGACA 8880 GAGATGGATG ATGGGGAGGG GGCTGGCCTG GAAGGACCCC CAGTGCAGGT GACATTGAAG 8940 CCAGGTTTCA AAGCTCCCAC AGGGAGCTGC CCAGAGAGAG TCCCCAAGGG GCAAGGTGAC 9000 TCGGGGGCAG GGGTAGGGCC TCTGTCAGGA GAGCCTAGGA GAGGCCTGTG TCTTCTAGGA 9060 AGAGCCCTGG CAGCCGAGCG GAGGCAGTGG TGAGGACCTG CATCCTGCAT GTCCAGCTGG 9120 CCTCACCCGG GGTCCCTGAG CCGGGTCTTA CGTGGCTCCC GCACTCGGGC GTTCAGAACG 9180 TGCCTGCGTG AGAAACGGTA GTTTCTTTAT TAGACGCGGA TGCAAACTCG CCAAACTTGT 9240 GGACAAAAAT GTGGACAAGA AGTCACACGC TCACTCCTGT ACGCGATTGC CGGCAGGGGT 9300 GGGGGAAGGG ATGGGGAGGC TTTGGTTGTG TCTGCAGCAG TTGGGAATGT GGGGCACCCG 9360 AGCTCCCACT GCAGAGGCGA CTGTGGAGAC AGAGAGCACC TGCAGGTCAT CCATGCAGTA 9420 TCGGCTTGCA TCCAGATCAT ACAGGGAACA CTATGATTCA ACAACAGACA GGGACCCCGT 9480 TTAAACATGG ACAAGGGGTC ACTCACGCCT GGAATCCCAG CAGTTTGGGA GGCCAGGGTG 9540 GGTGGATCGC TTGAGCCCAG GAGTTTGACA CCAGCCTGGG CAACAGGGTG AGACCCCGGT 9600 CTCTAAAAAA TAAAAGAACA TTGGCCGGGC GTGGTGGTAT GCATCTGTGG TCCCAGCTAT 9660 TCAGGAGACT GAGGTGGGAC ATCACTTGAG CCGAGGAGGT CAAGGCTGCA GTGAGCTGTG 9720 ATCACACCAC TGCACTCCAG GCTGGGTCAC AGAGCAAGAC CCTGTCTCAA AAAAAAAAAA 9780 AAAAAAAAAA AAAAATCACA GGATCTGAAC AGAGATTTCT CCAAAGAAGA CGCACAGATG 9840 GCCAACAGCG TGTGAGAAGA TGGTCGGCCT CATTAGTCAT GAGGGAAACG TAAATCAAAA 9900 CCACTGTCCA GCCGGGCGCG GTGCCTCACG CCTGTAATCC CAGCACTTTA GGAGAGCAGA 9960 TGGCTTGAGG CCAGGAGTTT GAGGCCAGCC TGGGCAACAT AGCGAGACCA ATAAATAGAT 10020 ATTAGTGGTG GCGCCTGTAG TCCCAGCTAG TTGGGAGGCT GAGGGGGGAG GATTCCCTGA 10080 GTCTATGAGG TTGAGACTGC AGTTAGCTGT GATGGTGCCA CTGCACTCCA GCCTGGGCGA 10140 CTAGGAAACG GTCTTTAAAA AAAAAAAAAA AAAACAGGGT GGGCGCGGTG GTTCACGCCT 10200 GTAATCTCAG CACTTTGGGA GGCCAAGGTG GGGGGATCAC AAGGTCAGGA GTTTGTGACC 10260 AGCCTGACCA ACATGGTGAA ACCCCGTTCT ACTAAAAATA CAAAAATTAG CGAGGTGTGG 10320 TCGTGGGCGC CTGTAATCCC AGCTAATTAG GAGGCTGAGG CAGGAGAATC ACTTGAACCC 10380 GGGAGGCGGA GGTTGCAGTG AGCCAATATC ACACCACTGC ACTCTAGCCT GGTCAACAGA 10440 GCGAGACTCT GTCTCAAAAA AAAAAAATGC TGAGCGTGGT GGCGCATGCC TGTAGTCTCA 10500 GCTACTTTGG GGGCTGAGGC AGGAGAATCG CTTGAACCTG GGAGGCAGAG GTCGCAGTGA 10560 GGCAAGATTG CACCATTGCA CTCCAGCCTG GGAGACAGAG TGAAACTCTG TCTCAAAAAG 10620 AAAAGGTCTA GGAAGAGTCC GCACCCTCTC CCCGCGGTGG CCACGCCGGG CTCCGCGCTG 10680 AGCCCTCTGT GTTCTTGTCT CTCCATACCT CATCACGGCA CCGCAGGGTT GCAGCCACTC 10740 CTGGTCTCAT TTTACACACC AGGAAATTGA GGCTCTTTGA GAAGCCGTGG TGATGATTTC 10800 ATCAGCATGC TCTGGGGCAG ACCCCTGCAG CCGCACAGGG TGCCTGGGGC CCACACTAGT 10860 GCCCTGGTTT ATAGACAGAC AGAGGTGGCA GTGGCGCTTC CGAGTCGGGC TGCGATGTGC 10920 TTGCACTCCC CGAGGGGCTG AGGGGCCCTG CGCCCAGGTG CAGCTGCTTG GGTGCTGCCA 10980 GCCCCTCCCA CCTCTCCCTC CCTGCCAGCC CCTCCCACCT CTCCCTCCCT GCCAGCCCCT 11040 CCCACCTCTC CCTCCCTGCC AGCCCCTCCC ACCTCTCCCT CCCTGCCAGC CCCTCCCACC 11100 TCTCCCTCCC TGCCAGCCCC TCCCACCTCT CCCTCCCTGC CAGCCCCTCC CACCTCTCCC 11160 TCCCTGCCAG CCCCTCCCAC CTCTCCCTCC CTCCAGCCCC TCCCACCTCT CCCTCCCTGC 11220 CAGCCCCTCC CACCTCTCCC TCCCTGCCAG CCCCTCCCAC CTCTCCCTCC CTGCCAGCCC 11280 CTCCCACCTC TCCCTCCCTG CCAGCCCCTC CCACCTCTCC CTCCCTGCCA GCCCCTCCCA 11340 CCTCTCCCTC CCTGCCAGCC CCTCCCACCT CTCCCTCCCT GGCTCATCCC TGCTGTGTCC 11400 CTTCTCTCTA GTTTCCTGTT CAGTTTCAGG AAGGAGGCTG GGAACCCAGA TGTAGGGAAT 11460 TTGCGCCCTG GAGTCAGACC TGGGTTCACG TCCCAGCGCC TCCACCTCTG GTGTGACCTT 11520 GGTCCAGTCT CTCAGCCTCA GTTTCCTCAC CTGTAAAGTG GGCTCCATGA TTAGATGCAC 11580 CCTGCAGGGC AGTGTAGCAG TGACCTGGCT CAGCCACTGG CAGCCCCAAC AATCATACCT 11640 TGTTAAAGTA GCTCTGTCGG TTCCCTCAGG GGTTCCGGGG GCCCATTCCC CTGTCCTCCA 11700 TGCACTGTGA GACCTGCCCT GCCACAGAGC AGAGTGTAAC AGCCTGAGGG TGAGAGCCAG 11760 ACACTGTGCC TGTGCTTAGA CCAGACACTG GACGACGGGA GCCAGTGCAG CCTGGGCGGG 11820 TGGACTCCTA TGGACCCCTC AGCACCCAGC CTCGGTGCCT TCAGCGCAGG GCCGCGTGGC 11880 TGTGGGGGCT CACAAGACCC GGCCCACTCC TGCTTGTGCC TACATCTGGG TGTTTGCCCA 11940 TTGGTGCCTT TTGACGCGTT CTGGTGTGTG TGAGACGTGC GGGGCTGGGA AGTGTTGGCA 12000 GAGCCGCGAG TACCGTCCTC ACTCCTTTTG TTCTTTTGAC GTAAGCTGGC GAGTGGCACT 12060 GCCTGAGTTC CGCTCAGTGC CCGCCCTGAT GTGCGGACCC CGCTGCATTC TTGCTGTTAG 12120 GTGGTGGCGG TGTGCGCTGT CGCTGGTGGG CACCGAGAGT CTTTGGGAGC TTTGGGGAGG 12180 TTGTGCCAAG CCTGAGCCTC GACGTCCCCC TTCCCGGCTT TCTGTTGGCT CTTCTGAGGC 12240 CAGGGCATCT CTATGAGGGC CTCCTGCTGG AGCCGTCTCT GTGGATCTCC TCTGCCATCC 12300 TGGCCCATGA GTGGGTGATG CGCTGGCCAC CATCTGGTGA CAGTGGCCGG GCACCGCTGC 12360 CAAATGTGGG TCCCGCATCT GCAAGCCCCT CCCTGGGTCC CCTAGGGTAT GGGGTGGTTC 12420 TGCCACTGCC CTCGCTCCCC CACCTTGGGG TGCCTCTCCC CCTGCTCGTG GGGGAGACCC 12480 TGCCTGGGAT CTGCTTTCCA GCAAGGAATA TACTTTGGAG GGAGACACAC ATGTTCTTTT 12540 CTGGAGCTCT GCAGTGGCCA CGGCAGCCCA GCCCGCCAAG CACCCTGGAA TGAAAACATC 12600 CCGCTGCTGT CTGGGCCTGG CCTGCACTCT GCTGCCTGCG CTCCAGCTGG CTGAGGCCGG 12660 GCACGTCTGC GGGCACAGCA GCGGGGGCGC CACAGTCTCC CTGCAGAGTG AGCGCAGCTG 12720 GAAAATGCAG CTCACGCCCT TTCCCAGAAC ACCTCGCTCT TCATGGCTTG GCAGCTGTCC 12780 TTGCCTAGGG GCCAGGGTGC CCAGGCACTG GTGGCAGGAG AAGGGCTACA TCTGGGGCTG 12840 AGGCGGGCTG GGTCCTTTTC TCCCTGCAGC TCCCGAGGCC CAGCCCTGGC CCAGCCTGGC 12900 ATTCCTGACC TTAGCAGCGC CATGATCTGA AGACAGGCTG GCTTCTGTGA GGCCACCTCA 12960 GAAAGGGCTT TGTGCCCAGG CAGAGGCGGA AGCCAGCTCT TCCTTCTGGT TGAGGCAGGA 13020 ATGAGGCCAG CGCTGGGCAA GCCCATGCCC AGGGAACGTC ACAGCTGTGG GAGTACAGGG 13080 GCTCCGGGTT CTGAGCCCGT CCACTGTGCA TCGTGGCCCT GGCCTCAGGA TGGCTCGTAC 13140 CATCATTGGC TGTGCCCACA GCCGAGTGGG TGATGGGATT CCGGCTGCCC CGCTGGATCT 13200 GTGCTGCTGC CCTCTCCAGG GCACTGCTGT GCCCGCACAG CCGGGCGCAG ATGGCCAGTT 13260 TGCTTGCCCC CCCCCCCACC ATCCTCTTCC TACCTTGGCT TCCTCCATTG ACACACTGGA 13320 CCCTGCTGGC TGCCCGGGGA GGTGTTTGGG GGATGGTGTT GGGGGAGGAG GAGGGCCCCT 13380 TGAGCCTCAG TGTGCCCATC AGGAGCGTAA GGTCAGTGCA GCACCTGCCC ACACAGGCTG 13440 TGAAGGGTGG GAGTGGAGAG GGATGCAAGG GGGTCACAAC GCCTGGCTCC ATGTCAGCTG 13500 CGTGCAGGGG CACCAGGAGC CGGCCCTCAT TCTCCCCTTG AACTGGAAGG GTGGCCCCGA 13560 CCCCAGCGGC AGGTAGCATA CGTATGAAGC GCTCTCCTTC CTACACCCCA CAGGTGGGCT 13620 CGTCTCCAGA CGGCCCTTTT TGAGCTGGCT GTGTTTTTCC ATCTGTGTAG GCAAGGACAT 13680 CGCAGACTCC CCTTTCTCAT CTCCCTCGTT CAGCCTCCGA GGCCGGAGTC TCCATCCCTG 13740 TGCCTGCCTG TGGGTCCCGG GAGGACCTGA GGCTGCCCAT GTCACCCCCG GCATCTCATC 13800 CTGGGGACAG TTCAGCCGTG GGAGGGATCT GTAAGGACAG AATGCCGCTG AGCCTGGGGC 13860 TCCCCAGCTA GTCTCACACC CCGTGTCTGG GACCCAGAGA CCCTCGTGCA GGGCTCTGTT 13920 GCTTGGGGCC TGGCAGCCTC GTCCTGTATC AGAGGCTGCC ACCCCCACCC CTCGTGGGGC 13980 CAGGGTTGTG GCCGGCCTCC CTGGCCCTCC CCATGGAAGT GGTAGGCGGA GCCAGCAGCC 14040 ATCTGCCCAG CCCGGGGCTG CACTGTTTTT TTTCAAATGA GCACCGTCCC AAACTGCAGC 14100 CCGTTAATTT AAACAGGATC ATTTCCGGCC CTGGAAGCCG CCTCACTCTC CTTAAATAGA 14160 AAGGAGCACA GCGCAGAGGG AAACAGATGA GGTCATGGCT CGGCTGGCCC AGCGAGGAAG 14220 GGGCCGCAGT GGGGGTGGCA CTGCCGCCTG TCCCCTGTCC TCTCCAGCGC CCACACTGCA 14280 GCCCATTTCC TCACCCTGGG CCTGCTCTCG GGAGGGACGG GCCTGGGGGT CCTCTTGCTG 14340 GGCGGAGGGG AACCAGCTCC TCCAGGAGAG GACGGGGCCT GGCAGGGGGC ATGGGGCCTC 14400 CCTGGGTCTG GCGTCCTGTC CTGCCCCTGC CGAGGGAGGA GCGGTTACAT AAGCTCCGCA 14460 GGCGGCCCCT CCGAGCCGGT CCCCCCAGCC CAGTTTCCAG TGAGGCGGCC AGCGCGGGCG 14520 GGGGTGCCGG GCCTGGCGCA CACCCGCTGC TGACCACACG TGTCTGGAAT GTGCAGATGT 14580 TTCTTTGGGG GCTCCGTCCG GCCCCCAGAC CCCACTCAGC ATCTGGTCTG GGGAGTGGGC 14640 GCCTGGGGCA CTCAGCTCTG AGTGTGAGAC TCTGAGGCAG GTCTGGTTTG TCTGGGGCCA 14700 TTCCCTCTGC TGTGGATTGG GAGGGCCCCG GGAGCTGCCC CACACCCAGG GAAGTTCTCC 14760 TCAGTCCCAC TGTTGCATTC CCCGACCCCG GCTCCCCCGG CCCAGGAGCG CCTGTGGGGC 14820 AGAAGGCCCA GCCCCAAGAC TTCCCGGCCC TGCCAGCCTC AGGCTTCACC CACCCTCGCG 14880 CCAACTGTGG GCAGAGCCCA GGGGGAGGGC AGGAGAGCCA GCGCCTGGCT GGGAACACCC 14940 C TG A GGGGCC GAGGCTCCAG GGCGAGGGGG CCCGACCTGG GGTTCACACG CCCGGGTGGC 15000 GGGCAGACCC GCTGCAGCAT GAGACACGTG TCAGCTACCT CGGGCCGGCA GGCTGGCCCT 15060 GCTGCCCACA GCCCTGGGAC GTGGCCCCAC CTGTGACGGG TGTGGAGGGG CAGCCTCCAG 15120 GCCTGGCCAC ACCCTCTGCT GTTGCTGCTC CTGCTCCAGG ATTGGCAAGG GTGCTGGGAA 15180 GGGGTGAAGA CCCGTACTGT GGCCACACAC CTGGGACTTC CTTCTCCACC CAGTGGTGCC 15240 CCAGCAGCCG CTAAGGAGCC CGCTGGGTCC CACGCTAGGA TGGTCCTAAC TCCTCCCGCC 15300 TTCCAGATCG GACGCTCGGC GCTGGGGACC CCTTGTGTCC CGGGGCTGGG GCACCGTCCT 15360 GCCCCCATGG GGGTGTACTC CTCCCGACAA GCTTGGCTTC AGCTTCCCTG GGAGCACATC 15420 CTGGCCCTCG GGCACCCATC AGGCTGTCCC TGTGCACCTG GCTCCCACCC TTCCAGCTCA 15480 TAGCAGGAAC TGGGGTGAGG AGTGCGTGGG GCAGCAAGGG CCTGGGACCC CAGAGGACCC 15540 TGCACTCTGC TCTGTGCTCT TGCCTGGGCT TAGGGCCGCT CGGTGGTCCT GCTGCCAGAT 15600 GCCTGGGCCC TGCTGTGTCC CCCATCCTTG CAGGGAACCA GAACGTGGGG GCAGGGCATC 15660 AGACAGCGGC GATGATGTCA CCTGGCGGGT GCAGAGGAAG CCCGAGGGGC GGGGTGGGGG 15720 GGCTGGCGCG AGGCTGCCTG GCTAGGCCTT GGCGTTCCCC CAGAACGGCG ATGGCAAAAG 15780 CAGATGGAGA CGTGAAAAAG TACGGGAGCA AGCGAGGTGA GGACTCCACG GGGACCCCTG 15840 TGCTGTTCCC TGTCCCTGAA GCCCACACCT GAGTCCTGCC CAGGGCAGAT GCTTCCACAC 15900 CCAGGGGGCA CCTGAGTCCT ACCCAGGGCA GACGCTTCCA CACCCTGGGG GCTGGGGGAC 15960 TGCACCTGGC TCCTGTCTGG GCCCCAGCTT CATTCCACTG CCCTGGGCCC TGGGAGCTCG 16020 GCCGAGCGGG GTCCCCAAGA CCTTGCTGCA TTTCTGGGCC TTGGGCTGGG GTGAGGGCCG 16080 GGAGAAGGAG CCAGCCTGGA GCCTGGCACG CAGGGAGTGC ATGGCCAGAA CCGGTGACAG 16140 GCAGGGCTGC CTGCTGGCGT GGAAGAAGTG TCCATGGCAC CCCCAGGCCT GGTTCACAGT 16200 GGGATGGGCG GGGAGCCGGG GGGCTCTGGG GTCCTCGGCT GACCTGCCCC CACCCCTGCC 16260 CTGGCTTGTC AGCTCCCAGC AGCAGCCACT CTTGATGGAT TTTCCAGAAA ATGAGGTGTG 16320 GCCAAACATC TTCAGGCTTT TCCTTCTTTC CTTTCTCCCG TGGCCTGGGT GGGAGCTGCT 16380 CCCCATGCCT GGGGGCAGGT GCGAGAGCCT GTGCCCCTCC CTGGGGCAGT TTCACAGCTG 16440 TGTCCCTTCC AGGGGGCCTG CCTGTGTTCA CCGTGGCCTC TGCAGCACCT CTCGCCCCTT 16500 AGGGCTCCTG CGCCTCGGGT CCCGGTGCCT CATTTCTCCC TAAAGCATTG GTTCTGCTGC 16560 CGCCGCAGCC GCTGGAAAGT CCCTCCTCAG GTCTAACTGC AGTTCCTCAC GGCACAGTGT 16620 TCCCCCTCGG GCATGGTGCT TGGGCAGTGG GTGTGAGTCC AGCTGCCTCA CCCTGTCTCG 16680 AGAATGGCCT CTTGCTGGTC TCCCAGCCAC CACCCTGTCC CACCCCACGG CGGGGATGGT 16740 GTGGATGCCT AGCAGCGCGG CTGTGGGCCC ACCCATCCTT ATGGGCAGTG GGGAGCACCT 16800 CAGCCCGTGT CCCTACCTTG GTGTAGAGGA GGGGACGGCA GAGAAGCAGG GTTCAGTTAG 16860 GGGGGAAGTG GTGGCCCTGC CGGAGGGGCC GTTCCCTGTG TGCCTGGCCC CCAGATCCTC 16920 TCCCCTCCCG GAGCCCAGGG CACAGGCATA GGCTCTCTGA GTGTCCCACA GCCCCTGGGG 16980 GAAGGGAACT GCACCCCCAA CCGTGCCCTC CATCCGCAGA TGGAACGAGA AGCTCCGGGA 17040 GCCAGTGCCC AGCGTCTCAT CTGTCTGGGC ACCCAGCCCA GGTGAGGGCC TGGCTCCACC 17100 GTCCGTGGCT GGTGCTGCTT CCTGGCACGG AGAAGGCCTC GGCTGCTCTG TCCCCTCAGC 17160 TGGGGTGGCC TCTGGTCCCC TTCTTTGTTG GTTCCCTTCT CAAGCTCTTG CCCTGGCCCC 17220 GGGCCCCACC GGGCAGCCTG TGTGTGCGTC TCTCCTGCGC CGGGTAGGCT CCTGTGGGAG 17280 CGGAGCTCCG GTGGGAGGAG CAGGGCTGGA GGCTGGCAGG GGCTGGGCGG GTGTTCAGGG 17340 ATGGAGGCCG CCCCGGCTTG GGGCTGGCTG CCGGGTGGTC ATTGCTGGGA AGAGCAAGTC 17400 TAGGCGGAGG CACCTGCTGG GTCACTCGTG GGGAGGGTGA CACCTGGGGA AGTAGAGGCC 17460 CGTGGCAGGA GGTGAGGCCT CGGGGTCCTG GGGAGCAGGG GGGTGGTGTG CAGACCTGCG 17520 GAGCCATAGT CCTGTGCCAG GAGCACTACT GGGAGTGCGT GGGACCAGGA GGGGTGCCCA 17580 GGGTGGGCGG CAGAGTGACC CCCGAGGTGC TTGAGGCCGA GGGGAGGTGG AGTTCTCGGT 17640 TTGCCCCAGC TCTCTGTCTA CTCACCTCCG CATCACCAGC TCCAGGACCT GGTTTGTAAC 17700 TCGGGCAGCT CTGAAAAGAG AGACATGCTG CCGCCCTGTG GTTTCTGTTG CTTTTTCTTC 17760 ACTGACTACT GACATGGGAT GTTTTTCCTA CGGCTGTGAC CAATTGTGCT TCTTCTAATT 17820 GCCTGGTTTT TCTTTTTTTG TTTTTGGAGT TTTCTCTTTC TTTCCTCCCT CCCTCTCACC 17880 CTCCATCCTT TTTTTTTTTA TTTTTATTTT TTGAGATGGA GCTTCACTCT TGCAGGATGG 17940 GGTGCTGGAG TGCAGGGGTG CGATCTCAGC TCACTGCAAC CTCTGCCTCG CGGGTTCAAG 18000 TGATTCTCCT GCCTAAGCCT CCTGAGTAGC TGGAATTACA GGTGCTTGCC ACCACGCCCG 18060 ACTAATTCTG TAGTTTTGGT AGAGACAGGG TGTCTCCGTG TTGGTCGGTC TGGTCTTGAA 18120 CTCCTGACCT CAGGTGATGC GCCCGCCTCA GCCTCCCAAA GTGCTGGGAT TACAGGCAGG 18180 AGCCATTGCA CCCGGCTCTT TCCCCTTCTC CTTTTCTTCT CTCTCTCCTC CCTTTCTTTC 18240 fpi i uiirn(~* r p r p'T 1 TV * "' T 1 T*T*T*T*" " FT 1 T^PT* CTTTTGAGAT GGAGTCTCGC TCTGTCACCA GGCTGGATTG 18300 CAGTGGCGTG ATCTTGGCTC ACTGCAACCT TCGCCTCCCG GGTTCACGTG ATTCTCCTGC 18360 CTCAGCCTCC TGAGTGGCTG GCACTACAGG CTCCCGCCGC CATGCCCGGC TAATTTTTGC 18420 ATTTTTAGTA GAGACAGGGT TTCACCCTGT TGGCCAGGAT GGTCTCGATC TCTTGATCTC 18480 ATGATCCACC CACCTTGGCC TCCCAAAGTT CTGGCATTAC AGGAGTGAGC CACCGTGCCC 18540 GGCCATCTTT CTTTCCTTGC TTTCTCTTTG TTTTCTTTCG AGACCGGGTC TTGCTCTGTC 18600 GCCCAGGCTG GACTGCAGTG GCACAATCAT AGCTCACTGC AGCCTCGACT TCCCTGGCTC 18660 AAGCGATCCT TCCTCCTCAG CCCCCCGAGT AGCTGGAACT ACAGTTACAC ACTACCATGC 18720 CTGGCTGATT CTTTTTTTCC TTGTAGAGAT GGGGTCTTGC TATGCTGTCC ATCCTGGTCT 18780 CAAACTCCTG GCCTTCCCAA AGCACTGGGT TTACAGGCAT AAGCCACCAC ACCCAGTTTC 18840 CTTTTCTTCT TTTTAACTGG AATAGTTGAC GTTTTCTTTA TTAGCTGTGT GTCAGGAGGG 18900 TATTTTTGGC CTTTAGTATG TCGTGTAAGT TGCTAGTGCT TTTCTGAGAT TGTAGTTTGT 18960 TTTCTAATTT TATTTATATT TTGCGTAGAA GTTGTGTATT TTAGATGGAG TTAGGTCGGC 19020 TGGTCTTTGA TGTTTTATTT ATTAATTATG TATGTATTTA TTTATTTTTG AGGTAGAGTC 19080 TCGCCGTTTC ACCCAGGCTG GAGTACAGTG ATGCGATCTC AGCTCCCTGT AGCCTTGACC 19140 TCTCTGGGCT CAAGTGATTT TTCTCTCCTC TACCTCCCGA GTACTTGGGA CCCCAGGCGC 19200 ATGCCGCCAT GCCTGGCTAA TGTGTATTTT TTGTAGATAC GGGGTCTCAC TGTGTTGCCC 19260 AGGGTGGTTT CAAAATCCTG GGCCCAGGCG ATCCTTCCGT CTCAGCTCCC ACGGTGCTGT 19320 GTTACCGGCG TGTGCCCAGT GCCTGGCCGT CTTGGAGGTC TTGTTTCTCT GGGTTTATGC 19380 CTCGAGGTGG CGCCTGCTCC CCTGTGCTCC CTGGTAGCCT GGTAGTGAGC CTGCTTCTCA 19440 CACAGTCATA CCTGGTTGTG GTCCCACAGT GGGACCACCC TGTTGGGTTC AGAACAGGAG 19500 ATGGGGGCCC CTCGAGTCTG TGTGGGGGCT GTGGACAGGG TTGGGAGACC TTGGCTCTGT 19560 GGGGGACTGT GGACAGGGGA TGGGGGGCCT TGGCCCTGCG TGGGATGGGT TGGGGGTCCG 19620 TGCCCTTCCT GGCCCTGGGT GGACAGGTCC ATGTGGCACT CGGCATAGGG CTGAGATGGG 19680 TGCAGAGGGC TGAGGCCCCC AGGCCTCTCC TGGCTTGGTT TCCCCAGATG AGTGTTCATT 19740 TGGGTCTTCC ATCAGAAAGT CCCCTCCTGA CCTCTGGGAG TGGGGAGCTC AAGGGTGGGA 19800 GGCCATAGCT TGGGGATGCT GGCAATGTGT GGGATGGGCC CAGGGAAGGC CTCTGGCCTA 19860 CTAGGGGCTC TGGCCCTGAC CCACGGCCAC TCACTCCTCA GAGACGTCTC CCACAACCTG 19920 CTCCGGGCGC TGGACGTTGG GCTCCTGGCG AACCTCTCGG CGCTGGCAGA GCTGTGAGTG 19980 TCCCCCAGTC GTGCCAGCAT GCGGGGCTCA CTCCGGGTGG GCTGGCGGCA CCGCCTCTTG 20040 CTGCTCAGCT GTGGGGGCTT CCATCAGCTT TGCCGAATCC CCCGTCTCTT CCAGGGATAT 20100 AAGCAACAAC AAGATTTCTA CGTTAGAAGA AGGAATATTT GCTAATTTAT TTAATTTAAG 20160 TGAAATGTAA GTTGTGGTTC TTTGGGTGGG GTCCTGGCTG GACCCCAGGC CCCCAATATC 20220 CCTTCTGCCC TCCCAGTTGG TCCGTGTCCC CTTCCAGGCT TGAGACCAGA TCCTGGGGGC 20280 AGTTCACTGC CTGCTTGGAG CCCCCCAGTG CCGGCTTGGT TGGGGCAGGG GAGGCGGTGC 20340 TGTCAGGGTG GCTCCAGGGC CTGGTTGCCA GTGGGGGGCT GGCATAGACC CTTCCCACCA 20400 GACCTGGTCC CCAACACCTG CCCCTGCCCT GCAGAAACCT GAGTGGGAAC CCGTTTGAGT 20460 GTGACTGTGG CCTGGCGTGG CTGCCGCGAT GGGCGGAGGA GCAGCAGGTG CGGGTGGTGC 20520 AGCCCGAGGC AGCCACGTGT GCTGGGCCTG GCTCCCTGGC TGGCCAGCCT CTGCTTGGCA 20580 TCCCCTTGCT GGACAGTGGC TGTGGTGAGT GCCGGTGGGT GGGGCCAGCT CTGTCCTTCC 20640 CAGCCAGGTG GGACCTGGGC CCTGCAGACA CTGGGCAGGG CTCAGGAAGG CCTCTCTGGG 20700 GGGGGCCTCC GGGCCAAGGG AACAGCATGG GAGCCTGTGA GTGCGGCGGG CGGATGTGGG 20760 GGCGTGGGGT GGAGCCAGGA GGAGCAGAAC CCGGGGTCCA GTGGCTGCCT CTTCTAGGTG 20820 AGGAGTATGT CGCCTGCCTC CCTGACAACA GCTCAGGCAC CGTGGCAGCA GTGTCCTTTT 20880 CAGCTGCCCA CGAAGGCCTG CTTCAGCCAG AGGCCTGCAG CGCCTTCTGC TTCTCCACCG 20940 GCCAGGGCCT CGCAGCCCTC TCGGAGCAGG GCTGGTGCCT GTGTGGGGCG GCCCAGCCCT 21000 CCAGTGCCTC CTTTGCCTGC CTGTCCCTCT GCTCCGGCCC CCCGCCACCT CCTGCCCCCA 21060 CCTGTAGGGG CCCCACCCTC CTCCAGCACG TCTTCCCTGC CTCCCCAGGG GCCACCCTGG 21120 TGGGGCCCCA CGGACCTCTG GCCTCTGGCC AGCTAGCAGC CTTCCACATC GCTGCCCCGC 21180 TCCCTGTCAC TGCCACACGC TGGGACTTCG GAGACGGCTC CGCCGAGGTG GATGCCGCTG 21240 GGCCGGCTGC CTCGCATCGC TATGTGCTGC CTGGGCGCTA TCACGTGACG GCCGTGCTGG 21300 CCCTGGGGGC CGGCTCAGCC CTGCTGGGGA CAGACGTGCA GGTGGAAGCG GCACCTGCCG 21360 CCCTGGAGCT CGTGTGCCCG TCCTCGGTGC AGAGTGACGA GAGCCTCGAC CTCAGCATCC 21420 AGAACCGCGG TGGTTCAGGC CTGGAGGCCG CCTACAGCAT CGTGGCCCTG GGCGAGGAGC 21480 CGGCCCGAGG TGAGTGTCTG CTGCCCACTC CCCTTCCTCC CCAGGGCCAT CCAGATGGGG 21540 CAGAGCCTGG TACCCCCGTC TTGGGCCCAC ACTGACCGTT GACACCCTCG TTCCCACCGG 21600 TCTCCAGCGG TGCACCCGCT CTGCCCCTCG GACACGGAGA TCTTCCCTGG CAACGGGCAC 21660 TGCTACCGCC TGGTGGTGGA GAAGGCGGCC TGGCTGCAGG CGCAGGAGCA GTGTCAGGCC 21720 TGGGCCGGGG CCGCCCTGGC AATGGTGGAC AGTCCCGCCG TGCAGCGCTT CCTGGTCTCC 21780 CGGGTCACCA GGTGCCTGCC CCCACCCCCC GAGGGGCCAT AGGTTGGGAG ATCTCTGAAG 21840 CACTGGGGCA GAGACTGCGG CTGGGGAGTC TCAGGAGGAA GGAGGTGGGA GCTGGGCCGG 21900 CCCTGGTGAG CAGGTGGCGC CGGCCGGTGG GGCCGTTCCT GTCAGCTCTG CAGATGCAGA 21960 GGTGGACATG AGCTGGGGGC AGCCTCCGGA CACTCCTGGG CACGCCATAC GGGAGGTGGC 22020 CTGCACGGGG ATCCCTGCCG GTACCCACAG GCCCCGTGGG TGGGTGCTGC TGTGAGCCTG 22080 GGCTGGTGGG CCCTGGTCTC CGGGCTCTGA GCCTCAGTTT CCCCATCTGG AAAGGGGGAC 22140 AGTGATGGGG CTCCCAGCGG GCTGCTGTGA GGGTGGGAGG ATGGAGGAGT GCCCTGAGCC 22200 CCCTGCCATC CCACACCCGC CCCCAGGAGC CTAGACGTGT GGATCGGCTT CTCGACTGTG 22260 CAGGGGGTGG AGGTGGGCCC AGCGCCGCAG GGCGAGGCCT TCAGCCTGGA GAGCTGCCAG 22320 AACTGGCTGC CCGGGGAGCC ACACCCAGCC ΛCAGCCGAGC ACTGCGTCCG GCTCGGGCCC 22380 ACCGGGTGGT GTAACACCGA CCTGTGCTCA GCGCCGCACA GCTACGTCTG CGAGCTGCAG 22440 CCCGGAGGTG TGCGGGGGGC CAGGCAGGGG CCTGAGACGC TGGCTGTGGT TAGGGGCCTG 22500 CCGAGCGCCC GCGGTGGAGC CTGGGCTGAG GAGGAGGGGC TGGTGGGGGG GTTTTCGGGC 22560 GGCTCGGTCC CCAGTCTGTT CGTCCTGGTG TCCTGGGCCC TGGCCCGGCG CCTCACTGTG 22620 CACTCGCCAC CCCAGGCCCA GTGCAGGATG CCGAGAACCT CCTCGTGGGA GCGCCCAGTG 22680 GGGACCTGCA GGGACCCCTG ACGCCTCTGG CACAGCAGGA CGGCCTCTCA GCCCCGCACG 22740 AGCCCGTGGA GGTAGTCGGC CCCCCACGTT CTACAACCTG CCCTCCTGCC TGCCCCTGGA 22800 GGCCTTGCCT GCCCTGCCCA CTGTGGGTCT CGCCAAAAAA CTTGGGGGCC TTAATGTTGC 22860 TTGTGCCCAG TGAAGATGGT TGGGAAAATC CAGAGTGCAG AGAGGAAAGC GTTTACTCAC 22920 ATTACCTCCA GGCCTTTTCT CTGAGCGTGT GTGAGTTATT CCTGAAAGGC AGGTCAGGGG 22980 TCCTGCCCCC CATGGACAGT TTCCACCGGA GTCTTCCTCT CGAGCGACAG GAGCCAGGCC 23040 TGTGGGGGTC TGATGGCTCG CTCTCCTTCC CTCCCCTCTT CCTGGGAAGT TCGGGTAGGG 23100 GGAGTCTGGG CTTCAGGCTG GGATGGGGTC TGTGGAGCTG AGGCGGCCCC CTGCCCACCA 23160 GGTCATGGTA TTCCCGGGCC TGCGTCTGAG CCGTGAAGCC TTCCTCACCA CGGCCGAATT 23220 TGGGACCCAG GAGCTCCGGC GGCCCGCCCA GCTGCGGCTG CAGGTGTACC GGCTCCTCAG 23280 CACAGCAGGT GGGACTCTGG GTGGTGGGTG GTGGGTGGTG GGCGCCGCAG GACTCGGGGT 23340 GGCCTCTCTG AGCTTTCACG TCTGCTGGTC CTGTGGCCAC CAGAGTGGTT CCCAGTCTTA 23400 GGTGGACAGA GCAGGGGTTC CAGAGACACC AGCTCATTCC AGGTGTCCTG GGGGTGGATT 23460 GGGTGGGGCC TGCCTGGGGG CCGGCCTGGG TCAGTCGGCT GGCCGGAGAC GGACGCAGCA 23520 CTGGGCTGGG AGTGCTGCCC AGGTGGGGAG ACCTGTCCTC ACAGCAAGGC CAGGATTGCT 23580 GGTGCAGGCA GTTGGGCATC TCTGACGGTG GCCTGTGGGC AAATCAGGGC CCCAACACCC 23640 TCCCCTCCTC ACAGGGACCC CGGAGAACGG CAGCGAGCCT GAGAGCAGGT CCCCGGACAA 23700 CAGGACCCAG CTGGCCCCCG CGTGCATGCC AGGGGGACGC TGGTGCCCTG GAGCCAACAT 23760 CTGCTTGCCG CTGGACGCCT CCTGCCACCC CCAGGCCTGC GCCAATGGCT GCACGTCAGG 23820 GCCAGGGCTA CCCGGGGCCC CCTATGCGCT ATGGAGAGAG TTCCTCTTCT CCGTTCCCGC 23880 GGGGCCCCCC GCGCAGTACT CGGTGTGTGG CCCTGACCTG GGTCTGTTCC CTGCATCTCC 23940 TCAGGCCACC TTCCTGTCTG CTGCCCAGGG TCTGGGTCTG TGCACCAGAC ACACCCAGCC 24000 TGCAGGCCCC TCCCACGTCC TTGCCACCTC TGACCTCCGA CCTCTGCAGT GCCCTCGGCC 24060 CTCTCCCAGT GGGAGAAGCT CTCGCCTGGG CCCTTGGCAC GAGCTGTGCC TCCTCTTCCT 24120 CTCTCCCAGC ACAGCTGCTC CTTCCTGTCT GCCAGGTCTT GGCCTGTGTC CTCTCCCCGT 24180 GTGTCCCCCG GTCTGCAACT GTCCTGCCTG TCCTTGTCAC GAGCACTGTG GGGAGGCTCC 24240 TTGAGGTGTG GCTGACGAAG CGGGGAGCCC TGCGTGTCCA CCCTCATCCG TCGTGCGGGG 24300 GTCCACGGGC CATGACCGTG AGGACGTGAT GCAGCCCTGC CTCCCTCTCC ACAGGTCACC 24360 CTCCACGGCC AGGATGTCCT CATGCTCCCT GGTGACCTCG TTGGCTTGCA GCACGACGCT 24420 GGCCCTGGCG CCCTCCTGCA CTGCTCGCCG GCTCCCGGCC ACCCTGGTCC CCGGGCCCCG 24480 TACCTCTCCG CCAACGCCTC GTCATGGCTG CCCCACTTGC CAGCCCAGCT GGAGGGCACT 24540 TGGGCCTGCC CTGCCTGTGC CCTGCGGCTG CTTGCAGCCA CGGAACAGCT CACCGTGCTG 24600 CTGGGCTTGA GGCCCAACCC TGGACTGCGG CTGCCTGGGC GCTATGAGGT CCGGGCAGAG 24660 GTGGGCAATG GCGTGTCCAG GCACAACCTC TCCTGCAGCT TTGACGTGGT CTCCCCAGTG 24720 GCTGGGCTGC GGGTCATCTA CCCTGCCCCC CGCGACGGCC GCCTCTACGT GCCCACCAAC 24780 GGCTCAGCCT TGGTGCTCCA GGTGGACTCT GGTGCCAACG CCACGGCCAC GGCTCGCTGG 24840 CCTGGGGGCA GTGTCAGCGC CCGCTTTGAG AATGTCTGCC CTGCCCTGGT GGCCACCTTC 24900 GTGCCCGGCT GCCCCTGGGA GACCAACGAT ACCCTGTTCT CAGTGGTAGC ACTGCCGTGG 24960 CTCAGTGAGG GGGAGCACGT GGTGGACGTG GTGGTGGAAA ACAGCGCCAG CCGGGCCAAC 25020 CTCAGCCTGC GGGTGACGGC GGAGGAGCCC ATCTGTGGCC TCCGCGCCAC GCCCAGCCCC 25080 GAGGCCCGTG TACTGCAGGG AGTCCTAGTG GTGAGTATGG CCGAGGCTCC ACCACCAGCC 25140 CCCAGGCAGG TGCCTGCAGA CAGGGTGCTC ACACAGGGCG TGAGGCCTGG CTTCCCAGTG 25200 AGGGCAGCAG CCCAGTTACT GGGGACGTCG GCCCCGGGCA GGTCCTGCTG GCTGGCTCCT 25260 CGGGCTACCT GGTGGGCTTT AAATTCCTGG AAAGTCACGG CTCTGACAGT GGCTCCGCTA 25320 ACTCATTCCA CTGTCTCATT TCACAAAATG AATTTAAAAC TCTGCTCCCT GACCTCACAC 25380 GAGCCCCCGT GAGTCTCTCA CGCCCTCTGC TGTGTTCTCG CCTGGCTAAA GCGAGTGGCT 25440 TTTGAGGTGG AGTCTGAACC CCTGATGGGA AACTGCGGGC TGCCCGCGGT GCCACCATGC 25500 TGGGTACATG GGGGACAGGG CTGTCTCCAT CTTGCGGGTA CCTGCCTCTT CACCAGGGGC 25560 CTTGGGAGGG GCCATCAGAA ATGGCGTGAC CTGTGCAGCC TGTCCTGGGT TCTGTAAGCC 25620 AGTGTAGGTG CCTCCCCTCA CTGCTCCGAG CTCTCTGGGT GAGGAGCTGG GGCAAGAGCG 25680 CCGGGAGGGT CTGAGAAGAC TCAGAGAGAG GTGGACTCTT TGTAGCTGGT ACTAGGTTTG 25740 CTTTACAGAT GGGGAAACTG AGGCACAGAG AGGTTGAGGC ATTAGTAGTA CTACATGGCT 25800 GGCTGGAGAG CCGGACAGTG AGTGTCCCAG CCCGGGCTTG GCTCCCATGG CATGCAGAGC 25860 CCCGGGCACC TCCTCTCCTC TGTGCCCCGC GTGGGACTCT CCAGCCCGAC GGGAGGTGTG 25920 TCCAGGAGGC GACAGGCTAA GGGCAGAGTC CTCCACAGAG CCCAGGCTGA CACCATTCCC 25980 CCCGCAGAGG TACAGCCCCG TGGTGGAGGC CGGCTCGGAC ATGGTCTTCC GGTGGACCAT 26040 CAACGACAAG CAGTCCCTGA CCTTCCAGAA CGTGGTCTTC AATGTCATTT ATCAGAGCGC 26100 G GCGGT C TTC AAGCTCTCAG TAGGTGGGCG GGGGTGGGGA GGGGAGGGGA TGGGGCGGGG 26160 CAGGGCGGGG GCGGGCTCCA CCTTCACCTC TGCCTTCTGC TCTGCTTCAT GCTGCCCGAG 26220 GACGCTGCCA TGGCTGTGGG TGAGTGGAGG GAGGGACGCC AATCAGGGCC AGGCCTCTCA 26280 CCTGCCACCT GGGCTCACTG ACGCCTGTCC CTGCAGCTGA CGGCCTCCAA CCACGTGAGC 26340 AACGTCACCG TGAACTACAA CGTAACCGTG GAGCGGATGA ACAGGATGCA GGGTCTGCAG 26400 GTCTCCACAG TGCCGGCCGT GCTGTCCCCC AATGCCACGC TAGCACTGAC GGCGGGCGTG 26460 CTGGTGGACT CGGCCGTGGA GGTGGCCTTC CTGTGAGTGA CTCGGGGGCC GGTTTGGGGT 26520 GGGCACCAGG CTCTTGTCCC AGCCCCAGCC TCAGCCGAGG GACCCCCACA TCACGGGGTT 26580 GCTTTTCTGA GCCTCGGTTT CCCTGTCTGT TGGGAGGTAA CTGGGTGCAC AGGAGCCCTG 26640 AGGCTGCACG GGAGCCGGGA GAGGCCTCAG CACAGCCGGG TGGGCCCTGA ATGGAGGCCC 26700 GGGGCGTGAC TGCAGAGTGG AGCCTCGGCT GGGTCCCAAG CACCCCCTGC CCCGCCACCG 26760 CCCACCCCTG TCCCGGTTCA CTCACTGCGT CCCACCGCCC CGGCAGGTGG ACCTTTGGGG 26820 ATGGGGAGCA GGCCCTCCAC CAGTTCCAGC CTCCGTACAA CGAGTCCTTC CCGGTTCCAG 26880 ACCCCTCGGT GGCCCAGGTG CTGGTGGAGC ACAATGTCAT GCACACCTAC GCTGCCCCAG 26940 GTGAGGGATG AGGGGGTGAG GGGGCCACTG CCTTTCAGGC TCTGAGCACG GGTCCCCCCA 27000 GCTCCCCAGT CAAGCTGCCC CCCTTCCTCC CCAACAGCCC TCACTGTGAC CTCACCTGGG 27060 CTGATGGCTT AGGCCCTACT GGGGTGAGGG AGGGGCCAGG CGTGGGGGGA GTGGACAGGG 27120 AAGCTGGGCC CCTGAACTGC GCCCCCCGCC CTCCCCGGGC CTGGCTCTTG CTGCTCTGCT 27180 GCCCCGAGTG CAGCTGCACT TGGAGGCGGT GCGTCCTCGC CAGGCAGCCC TCAGTGCTGC 27240 TACACCTGTG CTCCGTCCCG CACGTGGCTT GGGAGCCTGG GACCCTTAAG GCTGGGCCGC 27300 AGGTGCAGCC GTTCACCCCG GGCTCCTCAG GCGGGGGGCT TCTGCCGAGC GGGTGGGGAG 27360 CAGGTGGGGG TGCCGCGGCT GCCCCACTCG GGCCTGTCCC CACAGGTGAG TACCTCCTGA 27420 CCGTGCTGGC ATCTAATGCC TTCGAGAACC GGACGCAGCA GGTGCCTGTG AGCGTGCGCG 27480 CCTCCCTGCC CTCCGTGGCT GTGGGTGTGA GTGACGGCGT CCTGGTGGCC GGCCGGCCCG 27540 TCACCTTCTA CCCGCACCCG CTGCCCTCGC CTGGGGGTGT TCTTTACACG TGGGACTTCG 27600 GGGACGGCTC CCCTGTCCTG ACCCAGAGCC AGCCGGCTGC CAACCACACC TATGCCTCGA 27660 GGGGCACCTA CCACGTGCGC CTGGAGGTCA ACAACACGGT GAGCGGTGCG GCGGCCCAGG 27720 CGGATGTGCG CGTCTTTGAG GAGCTCCGCG GACTCAGCGT GGACATGAGC CTGGCCGTGG 27780 AGCAGGGCGC CCCCGTGGTG GTCAGCGCCG CGGTGCAGAC GGGCGACAAC ATCACGTGGA 27840 CCTTCGACAT GGGGGACGGC ACCGTGCTGT CGGGCCCGGA GGCAACAGTG GAGCATGTGT 27900 ACCTGCGGGC ACAGAACTGC ACAGTGACCG TGGGTGCGGC CAGCCCCGCC GGCCACCTGG 27960 CCCGGAGCCT GCACGTGCTG GTCTTCGTCC TGGAGGTGCT GCGCGTTGAA CCCGCCGCCT 28020 GCATCCCCAC GCAGCCTGAC GCGCGGCTCA CGGCCTACGT CACCGGGAAC CCGGCCCACT 28080 ACCTCTTCGA CTGGACCTTC GGGGATGGCT CCTCCAACAC GACCGTGCGG GGGTGCCCGA 28140 CGGTGACACA CAACTTCACG CGGAGCGGCA CGTTCCCCCT GGCGCTGGTG CTGTCCAGCC 28200 GCGTGAACAG GGCGCATTAC TTCACCAGCA TCTGCGTGGA GCCAGAGGTG GGCAACGTCA 28260 CCCTGCAGCC AGAGAGGCAG TTTGTGCAGC TCGGGGACGA GGCCTGGCTG GTGGCATGTG 28320 CCTGGCCCCC GTTCCCCTAC CGCTACACCT GGGACTTTGG CACCGAGGAA GCCGCCCCCA 28380 CCCGTGCCAG GGGCCCTGAG GTGACGTTCA TCTACCGAGA CCCAGGCTCC TATCTTGTGA 28440 CAGTCACCGC GTCCAACAAC ATCTCTGCTG CCAATGACTC AGCCCTGGTG GAGGTGCAGG 28500 AGCCCGTGCT GGTCACCAGC ATCAAGGTCA ATGGCTCCCT TGGGCTGGAG CTGCAGCAGC 28560 CGTACCTGTT CTCTGCTGTG GGCCGTGGGC GCCCCGCCAG CTACCTGTGG GATCTGGGGG 28620 ACGGTGGGTG GCTCGAGGGT CCGGAGGTCA CCCACGCTTA CAACAGCACA GGTGACTTCA 28680 CCGTTAGGTG GCCGGCTGGA ATGAGGTGAG CCGCAGCGAG GCCTGGCTCA ATGTGACGGT 28740 GAAGCGGCGC GTGCGGGGGC TCGTCGTCAA TGCAAGCCCC ACGGTGGTGC CCCTGAATGG 28800 GAGCGTGAGC TTCAGCACGT CGCTGGAGGC CGGCAGTGAT GTGCGCTATT CCTGGGTGCT 28860 CTGTGACCGC TGCACGCCCA TCCCTGGGGG TCCTACCATC TCTTACACCT TCCGCTCCGT 28920 GGGCACCTTC AATATCATCG TCACGGCTGA GAACGAGGTG GGCTCCGCCC AGGACAGCAT 28980 CTTCGTCTAT GTCCTGCAGC TCATAGAGGG GCTGCAGGTG GTGGGCGGTG GCCGCTACTT 29040 CCCCACCAAC CACACGGTAC AGCTGCAGGC CGTGGTTAGG GATGGCACCA ACGTCTCCTA 29100 CAGCTGGACT GCCTGGAGGG ACAGGGGCCC GGCCCTGGCC GGCAGCGGCA AAGGCTTCTC 29160 GCTCACCGTC TCGAGGCCGG CACCTACCAT GTGCAGCTGC GGGCCACCAA CATGCTGGGC 29220 AGCGCCTGGG CCGACTGCAC CATGGACTTC GTGGAGCCTG TGGGGTGGCT GATGGTGGCC 29280 GCCTCCCCGA ACCCAGCTGC CGTCAACAAA AGCGTCACCC TCAGTGCCGA GCTGGCTGGT 29340 GGCAGTGGTG TCGTATACAC TTGGTCCTTG GAGGAGGGGC TGAGCTGGGA GACCTCCGAG 29400 CCATTTACCA CCCATAGCTT CCCCACACCC GGCCTGCACT TGGTCACCAT GACGGCAGGG 29460 AACCCGCTGG GCTCAGCCAA CGCCACCGTG GAAGTGGATG TGCAGGTGCC TGTGAGTGGC 29520 CTCAGCATCA GGGCCAGCGA GCCCGGAGGC AGCTTCGTGG CGGCCGGGTC CTCTGTGCCC 29580 TTTTGGGGGC AGCTGGCCAC GGGCACCAAT GTGAGCTGGT GCTGGGCTGT GCCCGGCGGC 29640 AGCAGCAAGC GTGGCCCTCA TGTCACCATG GTCTTCCCGG ATGCTGGCAC CTTCTCCATC 29700 CGGCTCAATG CCTCCAACGC AGTCAGCTGG GTCTCAGCCA CGTACAACCT CACGGCGGAG 29760 GAGCCCATCG TGGGCCTGGT GCTGTGGGCC AGCAGCAAGG TGGTGGCGCC CGGGCAGCTG 29820 GTCCATTTTC AGATCCTGCT GGCTGCCGGC TCAGCTGTCA CCTTCCGCCT GCAGGTCGGC 29880 GGGGCCAACC CCGAGGTGCT CCCCGGGCCC CGTTTCTCCC ACAGCTTCCC CCGCGTCGGA 29940 GACCACGTGG TGAGCGTGCG GGGCAAAAAC CACGTGAGCT GGGCCCAGGC GCAGGTGCGC 30000 ATCGTGGTGC TGGAGGCCGT GAGTGGGCTG CAGGTGCCCA ACTGCTGCGA GCCTGGCATC 30D60 GCCACGGGCA CTGAGAGGAA CTTCACAGCC CGCGTGCAGC GCGGCTCTCG GGTCGCCTAC 30120 GCCTGGTACT TCTCGCTGCA GAAGGTCCAG GGCGACTCGC TGGTCATCCT GTCGGGCCGC 30180 GACGTCACCT ACACGCCCGT GGCCGCGGGG CTGTTGGAGA TCCAGGTGCG CGCCTTCAAC 30240 GCCCTGGGCA GTGAGAACCG CACGCTGGTG CTGGAGGTTC AGGACGCCGT CCAGTATGTG 30300 GCCCTGCAGA GCGGCCCCTG CTTCACCAAC CGCTCGGCGC AGTTTGAGGC CGCCACCAGC 30360 CCCAGCCCCC GGCGTGTGGC CTACCACTGG GACTTTGGGG ATGGGTCGCC AGGGCAGGAC 30420 ACAGATGAGC CCAGGGCCGA GCACTCCTAC CTGAGGCCTG GGGACTACCG CGTGCAGGTG 30480 AACGCCTCCA ACCTGGTGAG CTTCTTCGTG GCGCAGGCCA CGGTGACCGT CCAGGTGCTG 30540 GCCTGCCGGG AGCCGGAGGT GGACGTGGTC CTGCCCCTGC AGGTGCTGAT GCGGCGATCA 30600 CAGCGCAACT ACTTGGAGGC CCACGTTGAC CTGCGCGACT GCGTCACCTA CCAGACTGAG 30660 TACCGCTGGG AGGTGTATCG CACCGCCAGC TGCCAGCGGC CGGGGCGCCC AGCGCGTGTG 30720 GCCCTGCCCG GCGTGGACGT GAGCCGGCCT CGGCTGGTGC TGCCGCGGCT GGCGCTGCCT 30780 GTGGGGCACT ACTGCTTTGT GTTTGTCGTG TCATTTGGGG ACACGCCACT GACACAGAGC 30840 ATCCAGGCCA ATGTGACGGT GGCCCCCGAG CGCCTGGTGC CCATCATTGA GGGTGGCTCA 30900 TACCGCGTGT GGTCAGACAC ACGGGACCTG GTGCTGGATG GGAGCGAGTC CTACGACCCC 30960 AACCTGGAGG ACGGCGACCA GACGCCGCTC AGTTTCCACT GGGCCTGTGT GGCTTCGACA 31020 CAGGTCAGTG CGTGGCAGGG CCGTCCTCCA TGCCCCTCAC CCGTCCACAC CCATGAGCCC 31080 AGAGAACACC CAGCTTGCCA CCAGGGCTGG CCCGTCCTCA GTGCCTGGTG GGCCCCGTCC 31140 CAGCATGGGG AGGGGGTCTC CCGCGCTGTC TCCTGGGCCG GGCTCTGCTT TAAAACTGGA 31200 TGGGGCTCTC AGGCCACGTC GCCCCTTGTT CTCGGCCTGC AGAGGGAGGC TGGCGGGTGT 31260 GCGCTGAACT TTGGGCCCCG CGGGAGCAGC ACGGTCACCA TTCCACGGGA GCGGCTGGCG 31320 GCTGGCGTGG AGTACACCTT CAGCCTGACC GTGTGGAAGG CCGGCCGCAA GGAGGAGGCC 31380 ACCAACCAGA CGGTGGGTGC CGCCCGCCCC TCGGCCACTT GCCTTGGACA GCCCAGCCTC 31440 CCTGGTCATC TACTGTTTTC CGTGTTTTAG TGCTGGTGGA GGCCGCACGC TCTCCCCTCT 31500 CTGTTTCTGA TGCAAATTCT ATGTAACACG ACAGCCTGCT TCAGCTTTGC TTCCTTCCAA 31560 ACCTGCCACA GTTCCACGTA CAGTCTTCAA GCCACATATG CTCTAGTGGC AAAAGCTACA 31620 CAGTCCCCTA GCAATACCAA CAGTGAGGAA GAGCCCCTTC CCACCCCAGA GGTAGCCACT 31680 GTCCCCAGCC CATGTCCCTG TTGCTGGATG TGGTGGGCCG GTTCTCACCC TCACGCTCCC 31740 CTCTCTGGAC CGGCCAGGAG GCTTGGTGAC CCTGAGCCCG TGGTGGCTGC TCCTGCTGCT 31800 GTCAGGCGGG GCCTGCTGGT GCCCCAGAGT GGGCGTCTGT TCCCCAGTCC CTGCTTTCCT 31860 CAGCTGGCCT GATTGGGGGT CTTCCCAGAG GGGTCGTCTG AGGGGAGGGT GTGGGAGCAG 31920 GTTCCATCCC AGCTCAGCCT CCTGACCCAG GCCCTGGCTA AGGGCTGCAG GAGTCTGTGA 31980 GTCAGGCCTA CGTGGCAGCT GCGGTCCTCA CACCCACACA TACGTCTCTT CTCACACGCA 32040 TCCCCCCAGG GGCCCTCAGT GAGCATTGCC TGCCTCCTGC TAGGGTCCAG CTGGGTCCAG 32100 TACACCAGAA CGCACACTCC AGTGTCCTCT GCCCTGTGTA TGCCCTTCCG CCGTCCAAGT 32160 TGGAAGGTGG CAAACCGGAT GAGTATCCTG GGAGGGAGTG AGCTCACCGG CAGTGGCCAG 32220 GCCCCTGGGA AACCTGGAGT TTGGGAGCAG CATCCTCCAT GGGTCCCCCA GTCCTTCCAG 32280 CAGGCCAAAT AGACCTGTGT TGGAGGTAAC CCCACTCCCA CGCCAGGTGC TGATCCGGAG 32340 TGGCCGGGTG CCCATTGTGT CCTTGGAGTG TGTGTCCTGC AAGGCACAGG CCGTGTACGA 32400 AGTGAGCCGC AGCTCCTACG TGTACTTGGA GGGCCGCTGC CTCAATTGCA GCAGCGGCTC 32460 CAAGCGAGGG GTGAGTGTTG AGCGGGGTGT GGGCGGGCTG GGGATGGGTC CCATGGCCGA 32520 GGGGACGGGG CCTGCAGGCA GAAGTGGGGC TGACAGGGCA GAGGGTTGCG CCCCCTCACC 32580 ACCCCTTCTG CCTGCAGCGG TGGGCTGCAC GTACGTTCAG CAACAAGACG CTGGTGCTGG 32640 ATGAGACCAC CACATCCACG GGCAGTGCAG GCATGCGACT GGTGCTGCGG CGGGGCGTGC 32700 TGCGGGACGG CGAGGGATAC ACCTTCACGC TCACGGTGCT GGGCCGCTCT GGCGAGGAGG 32760 AGGGCTGCGC CTCCATCCGC CTGTCCCCCA ACCGCCCGCC GCTGGGGGGC TCTTGCCGCC 32820 TCTTCCCACT GGGCGCTGTG CACGCCCTCA CCACCAAGGT GCACTTCGAA TGCACGGGTG 32880 AGTGCAGGCC TGCGTGGGGG GAGCAGCGGG ATCCCCCGAC TCTGTGACGT CACGGAGCCC 32940 TCCCGTGATG CCGTGGGGAC CGTCCCTCAG GCTGGCATGA CGCGGAGGAT GCTGGCGCCC 33000 CGCTGGTGTA CGCCCTGCTG CTGCGGCGCT GTCGCCAGGG CCACTGCGAG GAGTTCTGTG 33060 TCTACAAGGG CAGCCTCTCC AGCTACGGAG CCGTGCTGCC CCCGGGTTTC AGGCCACACT 33120 TCGAGGTGGG CCTGGCCGTG GTGGTGCAGG ACCAGCTGGG AGCCGCTGTG GTCGCCCTCA 33180 ACAGGTGAGC CAGGCCGTGG GAGGGCGCCC CCGAGACTGC CACCTGCTCA CCACCCCCTC 33240 TGCTCGTAGG TCTTTGGCCA TCACCCTCCC AGAGCCCAAC GGCAGCGCAA CGGGGCTCAC 33300 AGTCTGGCTG CACGGGCTCA CCGCTAGTGT GCTCCCAGGG CTGCTGCGGC AGGCCGATCC 33360 CCAGCACGTC ATCGAGTACT CGTTGGCCCT GGTCACCGTG CTGAACGAGG TGAGTGCAGC 33420 CTGGGAGGGG ACGTCACATC TGCTGCATGC GTGCTTGGGA CCAAGACCTG TACCCCTGCC 33480 TGGAGCTTTG CAGAGGGCTC ATCCCGGGCC CCAGAGATAA ATCCCAGTGA CCCTGAAGCA 33540 GCACCCCGAC CTTCCGCTCC CAGCAGCCAC ACCCACCGGG CCCTCTCCGG CGTCTGCTTT 33600 CCACAATGCA GCCCCCGCCC AGGAGGGCCC ATGTGCTTAC CCTGTTTTGC CCATGAAGAA 33660 ACAGCTCAGT GTTGTGGGTC AGTGCCCGCA TCACACAGCG TCTAGCACGT AACTGCACCC 33720 CGGGAGTCGT GGGCATCTGC TGGCCTCCTG CCGGCCTCCT GCGCTGCTGA CAGCTTGCTG 33780 TGCCCCCTGC CTGCCCCAGT ACGAGCGGGC CCTGGACGTG GCGCAGAGCC CAAGCACGAG 33840 CGGCAGCACC GAGCCCAGAT ACGCAAGAAC ATCACGGAGA CTCTGGTGTC CCTGAGGGTC 33900 CACACTGTGG ATGACATCCA GCAGATCGCT GCTGCGCTGG CCCAGTGCAT GGTAGGATGG 33960 CCCCACCTGC TCACCCTGCC CCGCATGCCT GCCAGGGCAC TGGGTTCAGC CCCCCAGGGC 34020 AGACGGGCAG CTTGGCCGAG GAGCTGAGCC TCCAGCCTGG GCTCCTTCCT GCCATGGCGT 34080 TCCTCGGTCT CTGACCTGCT TCAGTAGCCT CAGCCGTTCT GTCCTGTGTG AACGCAGGGT 34140 GCCTCTCGGG GGACCCAGGG TGTAAAGAGG GGCCCAGATG TGGGGAGGGA CTAAGAAGAT 34200 GCTGCTCTGT GCCCTCCACT CTCCCCTCCC CTCCCCTCCC CCTTCCCTCC CCTAGCCCCT 34260 CCCCTCCTCC CCTCCCCTAG CCCTTCCCCT CCTCCCCTCC CCTAGCCCTT TCCCTTCTTC 34320 CCCCCCAGCC CTTCCCCTCC TCCCCTCCCC TAGCCCTTCC CCTCCTCCCC TCCCCTACCC 34380 CTTCCCCTCC TCCCCTCCCC TAGACCTTCC CCTCACCTCC TCCCGCTGAG CCCCTCCACT 34440 CGTCCCCCAG CCCCTCCCTC CCCTAGCCCC TCCCCTCCCC CTTCCTCCCC TCCTCCCCCT 34500 CCCCTCCTCC CCCTCCCTCT TCCTCCCCCT CCCCTCCTCC CCCTTCCTCC CCTCTCCTCC 34560 CCCTCCCCTC CTGTCCCCCC TCCTCCCCTC CTCCCTCCTC CCCTCCTCCC CCCTCCTCCT 34620 CCCCCTCCTC CCTCCTCCCT CCTCCCCCTC CTCCTCCTCC CCTCCTCCCT CCTCCCCTCC 34680 TCCCCTCCCC TCCTCCCCCT CCCCCCTCCC TTCCTCCCCC TCCCCCCTCC CCTCCTCCCC 34740 CTCTCCTCCT CCCATCCCTC CTCCCATCCC TCCTCCCCGT TCCCATTCTC TCCCCTCCCC 34800 CTTCCATTTC TCCCTCCTCC CCCTGCCCTC CTCTCCTCCT CACCTCCCCT TCTCCGCTCC 34860 TTTCTTCTCC TCCCTCCCTT TCTCTCCTCC CTCCCCTTCT CCCCTTCTCC TCTTCTCCCC 34920 TTCTCCTCTC TTTTCATCCT TCCCTTCTTC CCTCCTTTCC TCCTCTTTTC CCTCTTCTCC 34980 CCCCTCCTCC CCTCCTTCCT CCTCCCATTC CCCCTCCTCC CCCCTCCCAT TCCCCCTCCT 35040 CCCCTCCTTC CTCCTCCCAT TACCCCTCCT CTCCTCCCCT CCTCCCACCC CCCTCTCCTC 35100 CCGGCTCCTC TCCTCCCCTC CTCATCCCCC TCCTCTCCTT CCCTCCTAAC CCCCCTCCTC 35160 TCCTCCCCTC CTCATCCCCC TCCTCTCCTT CCCTCCTCCT ATCCCCCCTC CTCTCCTCCC 35220 CTCCTCCTAT TCCCCCTCCT CTCCTCCCCT CCTTCCTCCT CCTCTCCTCC CATGCCCCCT 35280 CCTCCCCTCC TCCCATCCCC CTCCTCCCCT CCTCCCTCCT CCCATCCCAT CCCCCTCCTC 35340 TCCTCCCCTT CTCTCCCCTC CTCTCCTCCC CTCCTCTCCT CTCCTCCTCT CCTCCCCTCC 35400 TCCCATCCCC CCTCCTCCCA TCCCCCCTCC TCTCCTCCCC ACTCCTCTCC TCCCCACTCC 35460 TCTCCTCCCC TCATCCCCCT CCTCTCTCCT CCCCTCCCCC TCCTCTCCTT CCCTCCTCCT 35520 TTCCTCCCCT CCCCCTCCTT CCCCCTCCTC CCCCTCCTTC TCCCCATCCC CCTTCCCCTT 35580 CTCCTCCTCT CCCCTCCCCC TTCTCTTTTT CCCTCCTCCT CCCTTCCTCC TCCCCTCTTC 35640 TCCCCTTTTC CCTTTTCTCT TCCTCTCCTC CCCTTCTCCC CTCCTGTCCT CCCTCCCTTT 35700 CTCTCTTTCT TTCCTCCCTT TCCTTCTCCC CTGTTCTCCT CCCTTCCCTT CTCCCCTTTT 35760 CTTCCCTCCT CCTTTCCTCC CCTCCTCCTT TTCTCTGTTT CTCTTCCTTT CCCCTCCACT 35820 TTCCCCTTCC TTTCCCCTCT CCTTTCTCCT TCCTTTCCTC TCCCCTTCTC TTCCTTTTCC 35880 TCTCTCCCCT TCTTTTCCCT CTTCCCCTCC CCTCCTCTTC CCCTCCCCTC CTCTTCCCCT 35940 CCCCTCCTCT TCCCCTCCCC TCCTCTTCCC CTCTCCTCCT CTTCCCCTCC CCTCCTCTTT 36000 CCCTCCCCTC TTCTCCTCCC CTCCTCTCCC CTCTTCCCCT CCCCTCCTCT TCCCTCCCCT 36060 TCCCCTCCCC TCCTCTTCCC TCCCCTTCCC CTCCCCTCCT CTTCCCTCCC CTTCCCCTCC 36120 TCTTCCTTCC TCTCTTCCCC TCCCCTCCTC TTCCCTCCCC TCTTCCCCTC CCCTTCTCTT 36180 CTCCTCCCCT TCTCTTCCCC TCCCCTTTTC TTCCCTCTCC TTGTCTTCCC TGCCCTCCTC 36240 TTCCCTCCCC TCCTCTTCCC TCCCCTCTTC CCCTCTCCTC CTCTTCCCTC CCCTCTTCCT 36300 CTTTCCTCTT CCCCTCCCCT CCTCCTCCCT CCCCTTTCCC CTCTTCCCCT CCCCTCCGCT 36360 TCCCTCCCCT TTCTCCCCCT TCTCTCCCCT CCCCTCTCCC CCCTTCTCTC CCCTCCCCTC 36420 TCCCCCTTCT CTCCCCTCCC CTCTCCCCCT TCTCTCCCCT CTCCTCTCCC CCTTCTCTCC 36480 CCCTTCTCTC CCCCTTCTCT CTCCCCTTCT CTCCCCCTTC TCTCCCCTCC CCCCTTCTCT 36540 CCCCTCCCCT CTCCCCCTTC TCTCCCCTCC CCTCTCCCCT GTCCTCTCCT CTCCACCCTT 36600 CTCTCCCCTC CCCTCTCCTC TCCCCCTTCC CTCTCCTCTC CCCCTTCTCT CCCCTCCCCT 36660 CTCCTCTCCC CCCTTTTCTC CACTCCCCTC TCCTCTCTCC CCTCCTCCTC CGCTCTCATG 36720 TGAAGAGGTG CCTTGTGTGG TCGGTGGGCT GCATCACGTG GTCCCCAGGT GGAGGCCCTG 36780 GGTCATGCAG AGCCACAGAA AATGCTTAGT GAGGAGGCTG TGGGGGTCCA GTCAAGTGGG 36840 CTCTCCAGCT GCAGGGCTGG GGGTGGGAGC CAGGTGAGGA CCCGTGTAGA GAGGAGGGCG 36900 TGTGCAAGGA GTGGGGCCAG GAGCGGGGCT GGACACTGCT GGCTCCACAC AGGGGCCCAG 36960 CAGGGAGCTC GTATGCCGCT CGTGCCTGAA GCAGACGCTG CACAAGCTGG AGGCCATGAT 37020 GCTCATCCTG CAGGCAGAGA CCACCGCGGG CACCGTGACG CCCACCGCCA TCGGAGACAG 37080 CATCCTCAAC ATCACAGGTG CCGCGGCCCG TGCCCCATGC CACCCGCCCG CCCCGTGCGG 37140 CCCTTTCCTC TGCCTCCCTC CTCCCCCCAA CCGCGTCGCC TTTGCCCCAT CCCATCTTCG 37200 TCCCCCTCCC CTCCCCCCAA TTCCCATCCT CATCCCCCTC CCCCAATTCC CATTCTCCTC 37260 CC C CTCCCCC TTCCCTATTA CCATCCCTTT TCTCCATCTC TCTCCCCTTT TCTCCATTTC 37320 CCCCCCCGTC CTCCCCGTCC TTTTGTCCAT TCCCCTCATC TTCCTCATCC CCCTCATCCC 37380 CCTTCCCCTC CCTTATCCCC CTTCCCCTCC CTTTCCCCCT GCTCCTCTTC TTCTCCCTTC 37440 TCTTTTCTCT ACCCTTTTCC TTCCTTTTTC CTCCCTCTCC CCATCATCCC CCTCATCTTC 37500 GTCCTCATCC CCATCACCTT CCCCCTCCCC CCTCCACCAC TCTCTCTCCA GCTTCCCCCT 37560 TCCTTCTGCC TGCACCTCGC TCTCTGCCCC CTCAGGTTCC CCCTTTCTCC CAGCCCCCAC 37620 CCTCCGGCTC CCCCTTTTTG CCTGCCCCCA CCCTCCCTCT ACCTCCCTGT CTCTGCACTG 37680 ACCTCACGCA TGTCTGCAGG AGACCTCATC CACCTGGCCA GCTCGGACGT GCGGGCACCA 37740 CAGCCCTCAG AGCTGGGAGC CGAGTCACCA TCTCGGATGG TGGCGTCCCA GGCCTACAAC 37800 CTGACCTCTG CCCTCATGCG CATCCTCATG CGCTCCCGCG TGCTCAACGA GGAGCCCCTG 37860 ACGCTGGCGG GCGAGGAGAT CGTGGCCCAG GGCAAGCGCT CGGACCCGCG GAGCCTGCTG 37920 TGCTATGGCG GCGCCCCAGG GCCTGGCTGC CACTTCTCCA TCCCCGAGGC TTTCAGCGGG 37980 GCCCTGGCCA ACCTCAGTGA CGTGGTGCAG CTCATCTTTC TGGTGGACTC CAATCCCTTT 38040 CCCTTTGGCT ATATCAGCAA CTACACCGTC TCCACCAAGG TGGCCTCGAT GGCATTCCAG 38100 ACACAGGCCG GCGCCCAGAT CCCCATCGAG CGGCTGGCCT CAGAGCGCGC CATCACCGTG 38160 AAGGTGCCCA ACAACTCGGA CTGGGCTGCC CGGGGCCACC GCAGCTCCGC CAACTCCGCC 38220 AACTCCGTTG TGGTCCAGCC CCAGGCCTCC GTCGGTGCTG TGGTCACCCT GGACAGCAGC . 38280 AACCCTGCGG CCGGGCTGCA TCTGCAGCTC AACTATACGC TGCTGGACGG TGCGTGCAGC 38340 GGGTGGGGCA CACGCGGCCC CCTGGCCTTG TTCTTGGGGG GAAGGCGTTT CTCGTAGGGC 38400 TTCCATGGGT GTCTCTGGTG AAATTTGCTT TCTGTTTCAT GGGCTGCTGG GGGCCTGGCC 38460 AGAGAGGAGC TGGGGGCCAC GGAGAAGCAG GTGCCAGCTC TGGTGCAGAG GCTCCTATGC 38520 TTTCAGGCCC GTGGCAGAGG GTGGGCTCAG GAGGGCCATC GTGGGTGTCC CCCGGGTGGT 38580 TGAGCTTCCC GGCAGGCGTG TGACCTGCGC GTTCTGCCCC AGGCCACTAC CTGTCTGAGG 38640 AACCTGAGCC CTACCTGGCA GTCTACCTAC ACTCGGAGCC CCGGCCCAAT GAGCACAACT 38700 GCTCGGCTAG CAGGAGGATC CGCCCAGAGT CACTCCAGGG TGCTGACCAC CGGCCCTACA 38760 CCTTCTTCAT TTCCCCGGGG TGAGCTCTGC GGGCCAGCCT GGCAGGGCAG GGCAGGGCAT 38820 CATGGGTCAG CATTGCCTGG GTTACTGGCC CCATGGGGAC GGCAGGCAGC GAGGGGACTG 38880 GACCGGGTAT GGGCTCTGAG ACTGCGACAT CCAACCTGGC GGAGCCTGGG CTCACGTCCG 38940 CTACCCCTTC CCTGCCCAGG AGCAGAGACC CAGCGGGGAG TTACCATCTG AACCTCTCCA 39000 GCCACTTCCG CTGGTCGGCG CTGCAGGTGT CCGTGGGCCT GTACACGTCC CTGTGCCAGT 39060 ACTTCAGCGA GGAGGACATG GTGTGGCGGA CAGAGGGGCT GCTGCCCCTG GAGGAGACCT 39120 CGCCCCGCCA GGCCGTCTGC CTCACCCGCC ACCTCACCGC CTTCGGCGCC AGCCTCTTCG 39180 TGCCCCCAAG CCATGTCCGC TTTGTGTTTC CTGTGAGTGA CCCTGTGCTC CTGGGAGCCT 39240 CTGCAGAGTC GAGGAGGGCC TGGGTGGGCT CGGCTCTATC CTGAGAAGGC ACAGCTTGCA 39300 CGTGACCTCC TGGGCCCGGC GGCTGTGTCC TCACAGGAGC CGACAGCGGA TGTAAACTAC 39360 ATCGTCATGC TGACATGTGC TGTGTGCCTG GTGACCTACA TGGTCATGGC CGCCATCCTG 39420 CACAAGCTGG ACCAGTTGGA TGCCAGCCGG GGCCGCGCCA TCCCTTTCTG TGGGCAGCGG 39480 GGCCGCTTCA AGTACGAGAT CCTCGTCAAG ACAGGCTGGG GCCGGGGCTC AGGTGAGGGG 39540 CGCAGCGGGG TGGCAGGGCC TCCCCTGCTC TCACTGGCTG TGCTGGTTGC ACCCTCTGGG 39600 AGTGAGTCTC GTCGCAGGCG TCAGAACAAG GCAGTTTTTG CAGTGCTGTG TGAAGGGCTC 39660 GTGTGTTCAT CCTGGGAATG ACCTCGTGAG CACTCACTGT CCCTGAGGAC TAGGACAGCT 39720 CCTAGCTGGA AGTAGGTGCC AGTCAGTCAG GGTGGGCAGC CCACGTTCTG CACAGTAGCG 39780 TGGCCCCACA AGTGACGTGA GCATCGCTAC CACTGTGGGA GACTGTGCAT CCACCCGCGA 39840 TCCTGACTGC ATAGCTCGTC TCTCAGACGG AGGCGCCAGC ACCCTCCCCG TGGCTGTTTC 39900 TTCAGTACCT CCATTTTCCT TTCATTGGAA TTGCCCTTCT GGCATTCCCT TTTTGTTTTC 39960 GTTTTTCTTT TTTTAGAGAC GGAGTCTCAC TCTGTTGCCC AGGCTGGAGT GCAATGGCAT 40020 GATCTTGGCT CACAGCAACT TCCAGCTCCC GGGTTTAAGC CATTCCCCTT AAGCGATTCT 40080 CCTGAGTAGC TGGGAGTACA GGTGCACACC ACCACACCCA GTTAATTTTT CACCATGTCA 40140 GCCAGGCGAA CTCCTGACCT CAGGTGATCC GCCTGCCTCG GCCTGCCAGA GTGCTGGGAT 40200 GACAGGTGTG AGCCACCACA CCTGGCTGTG TTCCCATTTT TTATCTCTGT GCTGCTTTCC 40260 TCTTCATTGC CCAGTTCTTT CTTTTGATTA CCTACTTTTA AAAACTGTCG GCCGGGCGCG 40320 GTGGCTCACA CCTGTAATCC GAGCACTTTG GGAGGCCAGG CAGGCAAATC ACGGGGTCAG 40380 GAGATCGAGA CCATCCTGGC TAACGGTGAA ACCCTGTCTC TAATAAAAAG TACAAAAAAA 40440 TTAGCCCGGC GTAGTGGCAG GCGCCTGTAG TCCCAGCTCC TTGGGAGACT GAGGCAGGAG 40500 AATGGCGTGA ACCCGGGAGG CGGAGCTTGC AGTGAGCTGA GATTGCGCCA CTGCACTCCA 40560 GCCTGGGTGA CACAGCAAGA CTCCATCTCA AAAAAAAAAG AAAAAAAATA CTGTCACCTG 40620 GGTCTGTCAC TGGGAGAGGA GGTGACACAG CTTCACGCTT TGCAGTCTGT GCATGAACTG 40680 AGGGACGGGT GTGTGGTGCG GGTCACCGGT TGTGGCATGA CTGAGGCGTG GACAGGTGTG 40740 CAGTGCGGGT CACTGGTTGT GGTGTGGACT GAGGCGTGTG CAGCCATGTT TGCATGTCAC 40800 AAGTTACAGT TCTTTCCATG TAACTTAATC ATGTCCTTGA GGTCCTGCTG TTAATTGGAC 40860 AAATTGCAGT AACCGCAGCT CCTTGTGTAT GGCAGAGCCG TGCAAAGCCG GGACTGCCTG 40920 TGTGGCTCCT TGAGTGCGCA CAGGCCAAAG CTGAGATGAC TTGCCTGGGA TGCCACACGT 40980 G TTG G GC A GC AGACCGAGCC TCCCACCCCT CCCTCTTGCC TCCCAGGTAC CACGGCCCAC 41040 GTGGGCATCA TGCTGTATGG GGTGGACAGC CGGAGCGGCC ACCGGCACCT GGACGGCGAC 41100 AGAGCCTTCC ACCGCAACAG CCTGGACATC TTCCGGATCG CCACCCCGCA CAGCCTGGGT 41160 AGCGTGTGGA AGATCCGAGT GTGGCACGAC AACAAAGGTT TGTGCGGACC CTGCCAAGCT 41220 CTGCCCCTCT GCCCCCGCAT TGGGGCGCCC TGCGAGCCTG ACCTCCCTCC TGCGCCTCTG 41280 CAGGGCTCAG CCCTGCCTGG TTCCTGCAGC ACGTCATCGT CAGGGACCTG CAGACGGCAC 41340 GCAGCGCCTT CTTCCTGGTC AATGACTGGC TTTCGGTGGA GACGGAGGCC AACGGGGGCC 41400 TGGTGGAGAA GGAGGTGCTG GCCGCGAGTA AGGCCTCGTT CCATGGTCCC ACTCCGTGGG 41460 AGGTTGGGCA GGGTGGTCCT GCCCCGTGGC CTCCTGCAGT GCGGCCCTCC CTGCCTTCTA 41520 GGCGACGCAG CCCTTTTGCG CTTCCGGCGC CTGCTGGTGG CTGAGCTGCA GCGTGGCTTC 41580 TTTGACAAGC ACATCTGGCT CTCCATATGG GACCGGCCGC CTCGTAGCCG TTTCACTCGC 41640 ATCCAGAGGG CCACCTGCTG CGTTCTCCTC ATCTGCCTCT TCCTGGGCGC CAACGCCGTG 41700 TGGTACGGGG CTGTTGGCGA CTCTGCCTAC AGGTGGGTGC CGTAGGGGTC GGGGCAGCCT 41760 CTTCCTGCCC AGCCCTTCCT GCCCCTCAGC CTCACCTGTG TGGCCTCCTC TCCTCCACAC 41820 AGCACGGGGC ATGTGTCCAG GCTGAGCCCG CTGAGCGTCG ACACAGTCGC TGTTGGCCTG 41880 GTGTCCAGCG TGGTTGTCTA TCCCGTCTAC CTGGCCATCC TTTTTCTCTT CCGGATGTCC 41940 CGGAGCAAGG TGGGCTGGGG CTGGGGACCC GGGAGTACTG GGAATGGAGC CTGGGCCTCG 42000 GCACCATGCC TAGGGCCGCC ACTTTCCAGT GCTGCAGCCA GAGGGAAAGG CGTCCACCAA 42060 AGGCTGCTCG GGAAGGGTCA ACACACTTGA GCAGCCTTAG CTAGACTGAC CAGGGAGAAA 42120 GAGAGAAGAC TCAGAAGCCA GAATGGTGAA AGAACGAGGG CACTTTGCTA AGCAGACGCC 42180 ACGGACGACT GCACAGCAGC ACGCCAGATA ACTCAGAAGA AGCAAGCACG CGGCTGTGCA 42240 CGCTTCCGAA ATGCACTCCA GAAGAAAATC TCAGTACATC TATAGGAAGT GAAGAGGCTG 42300 AGTTAGTCCC TTAGAAACGT CCCAGTGGCC GGGCCGGGTG TGGTGGCTCA CGCCTGTAAT 42360 CCCAACACTT CAGGTGGCCG AGGTGGGCGG ATCTGAGTCC AGGAGTTTGA GACCAGCCTG 42420 GGCAACATAG CAAGACCCCA TCTATATAAA ACATTAAAAA GGGCCAGGCG CGGTGGCTCA 42480 CGCCTGTAAT CCCAGCACTT TGGGAGGCCG AGGCGGGCAG ATCACTTGAG GTCAGGAGTT 42540 CGAGACCAGC CTGGCCAACA CAATGAAACC CCGACTCTAC TACAAATACA AAAACTTAGC 42600 TGGGCATGGT GGCGGGCGCC TGTAGTCCCA GCTACTCGAG AGGCTGAGGC AGGAGAATGG 42660 CATGAACCCA GGAGGCGGAG CTTGCAGTGA GCCGAGATTG CGCCACTGCA CTCCATCCTG 42720 GGCAACGGAG CAAGACTCCA TCTCCAAAAA AAAAAAAAAA AAATCCCACA AAGAAAAGCT 42780 CAGGCTCAGA GCCTTCACGA TAGAATTTTT CTAAGCAGTT AAGGAAGAAT TAACACCAAT 42840 CCTTCACAGA CTCTTTCCAA GAATACAGCA GGTGGGAACG CTTCCCATTC ATACGGAAAC 42900 GGGAGGCCGC ACCCCTTAGG AATGCACACG TGGGGTCCTC AAGAGGTTAC ATGCAAACTA 42960 ACCCCAGCAG CACACAGAGA AGGCGCATAA GCCGCGACCA GGAGGGGTTG CTCCCGAGTC 43020 CGTGGCAGGA ACCAGAGGCC ACATGTGGCT GCTCGTATTT AAGTTAATTA AAATGGAACG 43080 ATGGCCGGGT GTGGTGGCTC ACACCTGTAA TCCCAGCACT TTGGGAGGCG GAGGCGGGCA 43140 GATCACTTGA GGTCAGGAGT TCCAAGACCA GCCTGGCCAA CACAGTGAAA CCCCGTCTCT 43200 ACTAAAAATA CAAAAAATTA GCTGGGCATG GTGGCAGGCA CCTGTAATCC CAGCTACTCA 43260 GGAGGCTGAG CCAGGACAAT CGCCTGAACG CGGGAGGTGG AGGTTGCAGT GAGCTGAGAT 43320 TGCGCCATTG CACTCCAGCC TGGGTGACAG CGAGACTCCA TCTAAAAAAG AAAATATGAA 43380 ATTTAAAACT CTGTTCCTTA GCTGCACCAG TCTGCTGTCA AGTGTTCAGT GGCACACGTC 43440 GCGAGGGGCT GCCATCACGG ACGGTGCAGA TGTCCCATAT ATCCAGCATT CTAGGACATT 43500 CTGTCAGATG GCACCGGGCT CTGTCCTGTC TGCTGAGGAG GTGGCTTCTC ATCCCTGTCC 43560 TGAGCAGGTC TGAGCTGCCG CCCGCTGACC ACTGCCCTCG TCCTGCAGGT GGCTGGGAGC 43620 CCGAGCCCCA CACCTGCCGG GCAGCAGGTG CTGGACATCG ACAGCTGCCT GGACTCGTCC 43680 GTGCTGGACA GCTCCTTCCT CACGTTCTCA GGCCTCCACG CTGAGGTGAG GACTCTACTG 43740 GGGGTCCTGG GCTGGGCTGG GGGTCCTGCC GCCTTGGCGC AGCTTGGACT CAAGACACTG 43800 TGCACCTCTC AGCAGGCCTT TGTTGGACAG ATGAAGAGTG ACTTGTTTCT GGATGATTCT 43860 AAGAGGTGGG TTCCCTAGAG AAACCTCGAG CCCTGGTGCA GGTCACTGTG TCTGGGGTGC 43920 CGGGGGTGTG CGGGCTGCGT GTCCTTGCTG GGTGTCTGTG GCTCCATGTG GTCACACCAC 43980 CCGGGAGCAG GTTTGCTCGG AAGCCCAGGG TGTCCGTGCG TGACTGGACG GGGGTGGGCT 44040 GTGTGTGTGA CACATCCCCT GGTACCTTGC TGACCCGCGC CACCTGCAGT CTGGTGTGCT 44100 GGCCCTCCGG CGAGGGAACG CTCAGTTGGC CGGACCTGCT CAGTGACCCG TCCATTGTGG 44160 GTAGCAATCT GCGGCAGCTG GCACGGGGCC AGGCGGGCCA TGGGCTGGGC CCAGAGGAGG 44220 ACGGCTTCTC CCTGGCCAGC CCCTACTCGC CTGCCAAATC CTTCTCAGCA TCAGGTGAGC 44280 TGGGGTGAGA GGAGGGGGCT CTGAAGCTCA CCCTTGCAGC TGGGCCCACC CTATGCCTCC 44340 TGTACCTCTA GATGAAGACC TGATCCAGCA GGTCCTTGCC GAGGGGGTCA GCAGCCCAGC 44400 CCCTACCCAA GACACCCACA TGGAAACGGA CCTGCTCAGC AGCCTGTGAG TGTCCGGCTC 44460 TCGGGGGAGG GGGGATTGCC AGAGGAGGGG CCGGGACTCA GGCCAGGCAG CCGTGGTTCC 44520 CGCCTGGGGT AGGGTGGGGT GGGGTGCCAG GGCAGGGCTG TGGCTGCACC ACTTCACTTC 44580 TCTGAACCTC TGTTGTCTGT GGAAAGAGCC TCATGGGATC CCCAGGGCCC CAGAACCTTC 44640 CCTCTAGGGA GGGAGCAGGC TCATGGGGCT TTGTAGGAGC AGAAAGGCTC CTGTGTGAGG 44700 C T GGCCG G GG CCACGTTTTT ATCTTGGTCT CAGAGCAGTG AGAAATTATG GGCGGGTTTT 44760 TAAATACCCC ATTTTTGGCC GGGCGCGGTG GCTCACACGT GTAATCCCAG CACTTTGGGA 44820 GGCCGAGGTG GGCAGATGAC CTGAGGTCAG CAGTTCGAGA CCAGCCTGGC CAACATGGCG 44880 AAACCCCGTC TCTACTAAAA ATACAAAAAA TTAGCCGGGC ATGCTGGCAG GCGCCTGTAG 44940 TCCCAGTTAC TCGGGAGACT GAGGTAGGAG AATCGATTGA ACCTGGTAGG TGAAGGTTGT 45000 AGTGAGCCGA GATCGCGCCA CTGCACTCCA GCCTGGGCAA CAAGAGCGAA ACTCCGTCTC 45060 AAAAACAAAA AAATTCCTCA ATTTCTTGGT TGTTTTGTAA CTTATCAACA AATGGTCATA 45120 TAGAGGTTAC CTTGTATGTA GTCACGCACA TAGTCACGCA CATGGCAGCC GGCGGCGGAG 45180 CGCACCCACG GCGTGTTCCC ACGCGTGTGA CCCCGGGCTC TGCCATGCCC TCCTATGCTC 45240 AGGTGTGCTG AGGTCCACAC GGCCCTGCCG TTGCACTGCA GCTGCCTGCA GGATTCAGTG 45300 CAGTGGCATG CAGTGCAGGT GCGGTGCCCC GGAGCCACAG GCCACACCAC AGGGCCTGCA 45360 TGCACAGGGG CTGCGGTGTC TGGGTTTGGG TAACTACGCC CTGTGACATT TGCACAGCAA 45420 CAGAATTACC TAATGACGCA TTTCTCAGAA CACATCCCTG GCACTAAGTG GTGCGTGACT 45480 GCTGCTTTTG CATCCACATC TAGTTTGATT TGTGTGTTAT TCCTTTGAGT GCTTCTCATT 45540 GTTAAGCAAC CAAGAACTAA AGAGGTATGA ACTGCCCCTG GACTCAAACA AAAAGGAAAA 45600 CTTCCTGATT TACAAAAGGC AGATAACCAT CACATGAGGG CATCTTTATG AATAAATTGC 45660 TGGTTGGTTT TAAAAATACA GAGTATGGGG AAATCCAGGG GTAGTCACTA CATGCTGACC 45720 AGCCCCAGGT ATCTCCGGCC CAAAGCTCTG TGAAATCCAG ATTCAGTGCT TCCGCGGGGA 45780 TTTCTGACGG CAGCTCAGAC TCCGCATCCA CACAGAGCGC GTGGCCCTCA CCCTCCCGGC 45840 TTCCTCAACC CTTGGCCGTC CCTTGCTCGG ACAGTGCTTC GGGCTGACCA GGTCGGAGGC 45900 TTGGGTTTGT CCTGGACCCC TCTGCGTCCT TCCTCACTGC AGCCTCCAGC GCGTCCCGTG 45960 GCTCCTTTCC CAACGCAGAG CACGGCCTTC CCTGCGCCTG AGCCTGCACC CTCCGTCCTG 46020 GCGGCGCCTC TGCCCTGGCA TTCCCTGCCA CTCCATGCCT CCCTATTGGC CATTCTCCGT 46080 CTCTGCCAGC GAGAGCCTGC TCCCTGAGTC AGACCCTGAG TCATTTGTGT TGCTATAAAG 46140 GAATAGTTGA GGCTGGGTTA TTTTTTATTT TTATTTATTT TTTTGAGATG GAGTCTCTGT 46200 TGCCCAGACT GGAGTGCAGT CGCATGATCT CGGCTCACTG CAAAGTCTGC CTCCCACGTT 46260 CAAGCAGTTA TCTGCCTCAG CCTCCCAAGT AGCTAAGATT ACAGGCGCCC GCCGCCACAG 46320 CCGGCTAATT TTTTGTGTGT GTGTTTTAGT AGAGAGGAGG TTTCACCATC TTAGCCAGGC 46380 TGGTCTTGAA CTCCTGACCT CGTGATCCAC CCATCTCAGC CTCCCAAAAT GCTGAGATTA 46440 CAGGCGTGAG CCACCACGCC TGACCAAGTT GAGGCTAGGT CATTTTTTAA TTTTTTGTAA 46500 AGACAGGGTC TCACTGTCTC CAACTCCTGA GCTCAAGTGA TCCTCCTGCC TCAGCCTCCT 46560 GAAGTGCTGG GATTACAGGC TTGAGACACT GCGCCCAGCC AAGAGTGTCT TTTATCCTCC 46620 GAGAGACAGC AAAACAGGAA GCATTCAGTG CAGTGTGACC CTGGGTCAGG CCGTTCTTTC 46680 GGTGATGGGC TGACGAGGGC GCAGGTACGG GAGAGCGTCC TGAGAGCCCG GGACTCGGCG 46740 TCTCGCAGTT GGTCTCGTCC TCCCCCTCAA CGTGTCTTCG CTGCCTCTGT ACCTCTTCTC 46800 TAGCAGCTCT GGGACCGGGC ATATCAGCAT GGTGGCCCGA TGCAGTGGCA CAGCCTCGGT 46860 GGTCACTGGC TCCTGGAGAC ACAAGCAGAT CTCTGGCCTC AGGGAGCCCT ACACACTGTT 46920 GGGATTTGAA AGGCATTCAT ATGTTTCCTT GTCCAGAAGT TAATTTTAGG CCATAAACCT 46980 GCATGGGACA GACACACTGG CGTCTCTAGA TTGTAGAGAT GCTTGTTGGA TGGTTGAGAC 47040 CCAATCATAG TTTGCAGGGT TGAAGGGGGG CTCATTGCAC CCTGAGAGAC TGTGCACTGC 47100 TGTAAGGGCA GCTGGTCAGG CTGTGGGCGA TGGGTTTATC AGCAGCAAGC GGGCGGGAGA 47160 GGGACGCAGG CGGACGCCTG ACTTCGGTGC CTGGAGTGGC TCTTGGTTCC CTGGCTCCCA 47220 GCACCACTCC CACTCTCGTT TGGGGTAGGG TCTTCCGGCT TTTTGTCGGG GGGACCCTGT 47280 GACCCAAGAG GCTCAAGAAA CTGCCCGCCC AGGTTAACAT GGGCTTGGCT GCAACTGCCT 47340 CCTGGAGGCC GGGATGAATT CACAGCCTAC CATGTCCCTC AGGTCCAGCA CTCCTGGGGA 47400 GAAGACAGAG ACGCTGGCGC TGCAGAGGCT GGGGGAGCTG GGGCCACCCA GCCCAGGCCT 47460 GAACTGGGAA CAGCCCCAGG CAGCGAGGCT GTCCAGGACA GGTGTGCTTG CGTAGCCCCG 47520 GGATGCCCCT AGCCCCTCCC TGTGAGCTGC CJCTCACAGG TCTGTCTCTG CTTCCCCAGG 47580 ACTGGTGGAG GGTCTGCGGA AGCGCCTGCT GCCGGCCTGG TGTGCCTCCC TGGCCCACGG 47640 GCTCAGCCTG CTCCTGGTGG CTGTGGCTGT GGCTGTCTCA GGGTGGGTGG GTGCGAGCTT 47700 CCCCCCGGGC GTGAGTGTTG CGTGGCTCCT GTCCAGCAGC GCCAGCTTCC TGGCCTCATT 47760 CCTCGGCTGG GAGCCACTGA AGGTGAGGGG GCTGCCAGGG GTAGGCTACA GGCCTCCATC 47820 ACGGGGGACC CCTCTGAAGC CACCCCCTCC CCAGGTCTTG CTGGAAGCCC TGTACTTCTC 47880 ACTGGTGGCC AAGCGGCTGC ACCCGGATGA AGATGACACC CTGGTAGAGA GCCCGGCTGT 47940 GACGCCTGTG AGCGCACGTG TGCCCCGCGT ACGGCCACCC CACGGCTTTG CACTCTTCCT 48000 GGCCAAGGAA GAAGCCCGCA AGGTCAAGAG GCTACATGGC ATGCTGCGGG TGAGCCTGGG 48060 TGCGGCCTGT GCCCCTGCCA CCTCCGTCTC TTGTCTCCCA CCTCCCACCC ATGCACGCAG 48120 GACACTCCTG TCCCCCTTTC CTCACCTCAG AAGGCCCTTA GGGGTTCAAT GCTCTGCAGC 48180 CTTTGCCCGG TCTCCCTCCT ACCCCACGCC CCCCACTTGC TGCCCCAGTC CCTGCCAGGG 48240 CCCAGCTCCA ATGCCCACTC CTGCCTGGCC CTGAAGGCCC CTAAGCACCA CTGCAGTGGC 48300 CTGTGTGTCT GCCCCCAGGT GGGGTTCCGG GCAGGGTGTG TGCTGCCATT ACCCTGGCCA 48360 GGTAGAGTCT TGGGGCGCCC CCTGCCAGCT CACCTTCCTG CAGCCACACC TGCCGCAGCC 48420 A TGGCTCC A G CCGTTGCCAA AGCCCTGCTG TCACTGTGGG CTGGGGCCAG GCTGACCACA 48480 GGGCCCCCCC GTCCACCAGA GCCTCCTGGT GTACATGCTT TTTCTGCTGG TGACCCTGCT 48540 GGCCAGCTAT GGGGATGCCT CATGCCATGG GCACGCCTAC CGTCTGCAAA GCGCCATCAA 48600 GCAGGAGCTG CACAGCCGGG CCTTCCTGGC CATCACGCGG TACGGGCATC CGGTGCACTG 48660 GTCTGTCTTC TGGGCTTTAG TTTTGCCTTT AGTCCAGCCA GACCCTAGGG GACATGTGGA 48720 CATGTGTAGA TACCTTTGTG GCTGCTAGAA CTGGAGGTAG GTGCTGCTGG CATCAGTAGG 48780 CAGAGGGGAG GGACACAGGT CCGTGTCTTG CAGTGCACAG GACGGGCCCA TGACAGACAA 48840 CTGTCTGCCC CAGAACATCC CCAGGATAAG GCTGAGAAGC CCAGGTCTAG CCGTGGCCAG 48900 CAGGGCAGTG GGAGCCATGT TCCCTGGGTC TCTGGTGGCC GCTCACTCGA GGCGGGCATG 48960 GGGCAGTAGG GGCTGGAGCG TGTGACTGAT GCTGTGGCAG GTCTGAGGAG CTCTGGCCAT 49020 GGATGGCCCA CGTGCTGCTG CCCTACGTCC ACGGGAACCA GTCCAGCCCA GAGCTGGGGC 49080 CCCCACGGCT GCGGCAGGTG CGGCTGCAGG AAGGTGAGCT GGCAGGGCGT GCCCCAAGAC 49140 TTAAATCGTT CCTCTTGTTG AGAGAGCAGC CTTTAGCGGA GCTCTGGCAT CAGCCCTGCT 49200 CCCTAGCTGT GTGACCTTTG CCCTCTTAAC ACCGCCGTTT CCTTCTCTGT ATATGAGAGA 49260 TGGTAACGTT GTCTAATTGA TGGCTGCTGG GAGGGTTCCC TGGGGTGGCG CCGAACCAGA 49320 GCTCAGGCGA GCTGGCCAGC AGGAAACACT CCTGTTGGGT TTTGATGAGG CCCTGGCCCC 49380 GGCCTGGGGC TCTGTGTGTT TCAGCACTCT ACCCAGACCC TCCCGGCCCC AGGGTCCACA 49440 CGTGCTCGGC CGCAGGAGGC TTCAGCACCA GCGATTACGA CGTTGGCTGG GAGAGTCCTC 49500 ACAATGGCTC GGGGACGTGG GCCTATTCAG CGCCGGATCT GCTGGGGTGA GCAGAGCGAG 49560 GGCCCCGGGC GTCTACGCCA AGGACAAGGG AGTAGTTCTC CAGGAGTGCC GCGGCCTCCT 49620 GACCAGCCTG GCTCCGGGGT GCCGGAAGGG CTGGGGTGCG GCACCCACGC CACCCCTCTC 49680 CGGCAGGGCA TGGTCCTGGG GCTCCTGTGC CGTGTATGAC AGCGGGGGCT ACGTGCAGGA 49740 GCTGGGCCTG AGCCTGGAGG AGAGCCGCGA CCGGCTGCGC TTCCTGCAGC TGCACAACTG 49800 GCTGGACAAC AGGTGGGAGC TCCCTCCCCT GCCCTCTCCG GGGTGGCCGC AGTCACCAGC 49860 CAGGAGCCCA CCCTCACTCC TCCGGCCCCC GCTGGCCTAG GCGGCTTCCA CAGCCCCTCA 49920 GCCACGCCTG CACTGCGCGG TCCCCGCAGC TCCCGCCCTG CCACCCGCTC CTACTGACCC 49980 GCACCCTCTG CGCAGGAGCC GCGCTGTGTT CCTGGAGCTC ACGCGCTACA GCCCGGCCGT 50040 GGGGCTGCAC GCCGCCGTCA CGCTGCGCCT CGAGTTCCCG GCGGCCGGCC GCGCCCTGGC 50100 CGCCCTCAGC GTCCGCCCCT TTGCGCTGCG CCGCCTCAGC GCGGGCCTCT CGCTGCCTCT 50160 GCTCACCTCG GTACGCCCGT CCCCGGCCAG ACCCCGCGCC TCCCACCGGC AGCGTCCCGC 50220 CCCCTCGCGG GGCCCCGCCC GGCAGCGTCT CACCCCTCGC AGCGCCCCGC CCCCTCGCAG 50280 CGTCCCGCCC CCTCGCAGGG CCCCGCCCCG GCAGCGTCCC GCCCCCTCGT AGGGCCCCGC 50340 CCCGGCAGCG TCCCGCCCCC TCGCAGGGCC CCGCCCCGGC AGCGTCCCTC CCGCCCTCCT 50400 GACCGCGCCC CCCACAGGTG TGCCTGCTGC TGTTCGCCGT GCACTTCGCC GTGGCCGAGG 50460 CCCGTACTTG GCACAGGGAA GGGCGCTGGC GCGTGCTGCG GCTCGGAGCC TGGGCGCGGT 50520 GGCTGCTGGT GGCGCTGACG GCGGCCACGG CACTGGTACG CCTCGCCCAG CTGGGTGCCG 50580 CTGACCGCCA GTGGACCCGT TTCGTGCGCG GCCGCCCGCG CCGCTTCACT AGCTTCGACC 50640 AGGTGGCGCA GCTGAGCTCC GCAGCCCGTG GCCTGGCGGC CTCGCTGCTC TTCCTGCTTT 50700 TGGTCAAGGT GAGGGCTGGG CCGGTGGGCG CGGGGCTGGG CGCACACCCC AGGGCTGCAA 50760 GCAGACAGAT TTCTCGTCCG CAGGCTGCCC AGCAGCTACG CTTCGTGCGC CAGTGGTCCG 50820 TCTTTGGCAA GACATTATGC CGAGCTCTGC CAGAGCTCCT GGGGGTCACC TTGGGCCTGG 50880 TGGTGCTCGG GGTAGCCTAC GCCCAGCTGG CCATCCTGGT AGGTGACTGC GCGGCCGGGG 50940 AGGGCGTCTT AGCTCAGCTC AGCTCAGCTG TACGCCCTCA CTGGTGTCGC CTTCCCCGCA 51000 GCTCGTGTCT TCCTGTGTGG ACTCCCTCTG GAGCGTGGCC CAGGCCCTGT TGGTGCTGTG 51060 CCCTGGGACT GGGCTCTCTA CCCTGTGTCC TGCCGAGTCC TGGCACCTGT CACCCCTGCT 51120 GTGTGTGGGG CTCTGGGCAC TGCGGCTGTG GGGCGCCCTA CGGCTGGGGG CTGTTATTCT 51180 CCGCTGGCGC TACCACGCCT TGCGTGGAGA GCTGTACCGG CCGGCCTGGG AGCCCCAGGA 51240 CTACGAGATG GTGGAGTTGT TCCTGCGCAG GCTGCGCCTC TGGATGGGCC TCAGCAAGGT 51300 CAAGGAGGTG GGTACGGCCC AGTGGGGGGG AGAGGGACAC GCCCTGGGCT CTGCCCAGGG 51360 TGCAGCCGGA CTGACTGAGC CCCTGTGCCG CCCCCAGTTC CGCCACAAAG TCCGCTTTGA 51420 AGGGATGGAG CCGCTGCCCT CTCGCTCCTC CAGGGGCTCC AAGGTATCCC CGGATGTGCC 51480 CCCACCCAGC GCTGGCTCCG ATGCCTCGCA CCCCTCCACC TCCTCCAGCC AGCTGGATGG 51540 GCTGAGCGTG AGCCTGGGCC GGCTGGGGAC AAGGTGTGAG CCTGAGCCCT CCCGCCTCCA 51600 AGCCGTGTTC GAGGCCCTGC TCACCCAGTT TGACCGACTC AACCAGGCCA CAGAGGACGT 51660 CTACCAGCTG GAGCAGCAGC TGCACAGCCT GCAAGGCCGC AGGAGCAGCC GGGCGCCCGC 51720 CGGATCTTCC CGTGGCCCAT CCCCGGGCCT GCGGCCAGCA CTGCCCAGCC GCCTTGCCCG 51780 GGCCAGTCGG GGTGTGGACC TGGCCACTGG CCCCAGCAGG ACACCCCTTC GGGCCAAGAA 51840 CAAGGTCCAC CCCAGCAGCA CTTAGTCCTC CTTCCTGGCG GGGGTGGGCC GTGGAGTCGG 51900 AGTGGACACC GCTCAGTATT ACTTTCTGCC GCTGTCAAGG CCGAGGGCCA GGCAGAATGG 51960 CTGCACGTAG GTTCCCCAGA GAGCAGGCAG GGGCATCTGT CTGTCTGTGG GCTTCAGCAC 52020 TTTAAAGAGG CTGTGTGGCC AACCAGGACC CAGGGTCCCC TCCCCAGCTC CCTTGGGAAG 52080 GACACAGCAG TATTGGACGG TTTCTAGCCT CTGAGATGCT AATTTATTTC CCCGAGTCCT 52140 CAGGTACAGC GGGCTGTGCC CGGCCCCACC CCCTGGGCAG ATGTCCCCCA CTGCTAAGGC 52200 TGCTGGCTTC AGGGAGGGTT AGCCTGCACC GCCGCCACCC TGCCCCTAAG TTATTACCTC 52260 TCCAGTTCCT ACCGTACTCC CTGCACCGTC TCACTGTGTG TCTCGTGTCA GTAATTTATA 52320 TGGTGTTAAA ATGTGTATAT TTTTGTATGT CACTATTTTC ACTAGGGCTG AGGGGCCTGC 52380 GCCCAGAGCT GGCCTCCCCC AACACCTGCT GCGCTTGGTA GGTGTGGTGG CGTTATGGCA 52440 GCCCGGCTGC TGCTTGGATG CGAGCTTGGC CTTGGGCCGG TGCTGGGGGC ACAGCTGTCT 52500 GCCAGGCACT CTCATCACCC CAGAGGCCTT GTCATCCTCC CTTGCCCCAG GCCAGGTAGC 52560 AAGAGAGCAG CGCCCAGGCC TGCTGGCATC AGGTCTGGGC AAGTAGCAGG ACTAGGCATG 52620 TCAGAGGACC CCAGGGTGGT TAGAGGAAAA GACTCCTCCT GGGGGCTGGC TCCCAGGGTG 52680 GAGGAAGGTG ACTGTGTGTG TGTGTGTGTG CGCGCGCGCA CGCGCGAGTG TGCTGTATGG 52740 CCCAGGCAGC CTCAAGGCCC TCGGAGCTGG CTGTGCCTGC TTCTGTGTAC CACTTCTGTG 52800 GGCATGGCCG CTTCTAGAGC CTCGACACCC CCCCAACCCC CGCACCAAGC AGACAAAGTC 52860 AATAAAAGAG CTGTCTGACT GCAATCTGTG CCTCTATGTC TGTGCACTGG GGTCAGGACT 52920 TTATTTATTT CACTGACAGG CAATACCGTC CAAGGCCAGT GCAGGAGGGA GGGCCCCGGC 52980 CTCACACAAA CTCGGTGAAG TCCTCCACCG AGGAGATGAG GCGCTTCCGC TGGCCCACCT 53040 CATAGCCAGG TGTGGGCTCG GCTGGAGTCT GTGCAGGGGC TTTGCTATGG GACGGAGGGT 53100 GCACCAGAGG TAGGCTGGGG TTGGAGTAGG CGGCTTCCTC GCAGATCTGA AGGCAGAGGC 53160 GGCTTGGGCA GTAAGTCTGG GAGGCGTGGC AACCGCTCTG CCCACACACC CGCCCCACAG 53220 CTTGGGCAGC CAGCACACCC CGCCTGAGGG AGCCCCATAT TCCCTACCCG CTGGCGGAGC 53280 GCTTGATGTG GCGGAGCGGG CAATCCACTT GGAGGGGTAG ATATCGGTGG GGTTGGAGCG 53340 GCTATGATGC ACCTGTGAGG CCATCTGGGG ACGTAGGCAG GGGGTGAGCT CACTATCAGG 53400 TGGCACCTGG GCCTGTCCCA CCAGCTCACG CCTGGACCCA CCCCCACTCA CATTTGCGTG 53460 CAGGGCCATC TGGCGGGCCA CGAAGGGCAG GTTGCGGTCA GACACGATCT TGGCCACGCT 53520 GGTGTCCACA AGGCCCTCCA TGTCTGGGGA GACTTGGTGG TCACGCCAGG CCCAGGG 53577 (2) INFORMATION FOR SEQ ID NO:2: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 53526 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) ( xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 2 : TGTAAACTTT TTGAGACAGC ATCTCACCCT GTTCCCCAGG CTGGAGTGCA GTGGTGTGAT 60 CATGGCTCAC TGCAGCGTCA ACCTCCTGGG TCTACTTGAT CTGTAAACTT CGAGGGAAGG 120 TGTAATAAAC CCTCCTGCAA TGTCTTTGTT TTTCAAAATC TTTGTATTTC ACAGTTTAGC 180 TTCGTGGGTT GATGTTCTAT TTTGTTTTTG TGTGTGTGTG TGTGTGTTTT GTGTTTTTTT 240 TTGAGACACA GTCTTGCTCT TGTTGCCCAG GCTGGAGTGC AATGGTGTGA TCTTGGCTCA 300 CTGCAACTTC CACCTCTTGG GTTCAAGAGA TTCTCCTGCC TCAGCCTTCC GAGTAGCTAG 360 GATTACAGGC GCCGCCACCA CACCCCGCTA ATTTTGTATT TTTAGTAGAG ATGGGGTTTC 420 TCCATATTGG TCAGGCTGGT CTCAAACTCC CGACCTCAGG TGATCCGCCC ACCTCAGCCT 480 CCCAAAATGC TGGGATTACA GGCGTGAGTC ACCGCACCTG GCCAATGTTC TATTTTTGAG 540 AACACAACAG TTCATAATAT ATTCTACATA GACCATACCT GTTATGTGTA GATAAACAGA 600 CTCTTTTCCC ATTTAACACC TTTTGCCTTA GGTTTATTTT TCTGGTATCA ATACTGGCAC 660 ACTTACTTTG TTTGCAGTTT CCTGTCTTTT TTTTTTTTTT GAGACAGAGT 720 CTCACTCTGT CACCCAGGCT GGAGTGAAGT GGCGGGATCT CGGCTCACTG CAACCTCTAC 780 CTCCTGGGTT CATGCGATTC TCCTGCCTCA GCTTCCCGAA TAGCTGAGAC CACAACTGTG 840 TGCCACCATG CCCAGCCAAT TTTTGTATTT TTAGTAGACA CGGGGTTTCA CCATACTGGC 900 CAGGATGGCT CAATCTCTTG ACCTCGTGAT CCACCTGCCT CCGCCTCCCA AAGTGCTGGG 960 ATTACAGGCA TGAGCCACTG TGCCTGGCCT TTTTTTTTCT TTTTGAGATG GAGTCTCACT 1020 CTGTCACCCA GGCTGGAGTG CAGTGGGGTA ACCTCAGGTC ACTGCGACCT CCGCCTCCCG 1080 GGTTCCAGTG ATTCTCCTGC CTCAGCCTCC CGAGTAGCTG GGATTACAGG CACCCACCAC 1140 CATGCCTGGC TAATTTTTGT ATTTTTAGTA GAGACGGGGT TTTGCCACGT TGGCCAGGTT 1200 GGTCTCGAAC TCTTGGCCTC ATGTGACCCG CCTGCCTTGG CCTCCCAAAG TGCTGGGATT 1260 ACAGGTGTGA GCCACTGTGC CTGGCCTGGC TTTCTTGTTT CTTTTCTCCT CTTCTAGTTT 1320 CCCCCTTTTA GGCTAACAAT TATTCACTGT TAATAAAAAC CCTCAGGTCT GTATTTTATC 1380 AAGAAACATT TCCCTCACGT CTTCTTCCCT GAACCAAACA AGATCTCTGG CACATTTTAT 1440 TTGCTCTGTC TCACCACATG GATTTTGTTT TTTTGTTTCT TTGTTTTTTG AGATGGAGTC 1500 TCACTCTTGT TGCCCAGGCT GGAGTGCCAT GGCACAATCT CAGCTCACTG CAACCTCCAC 1560 CTCCTGGGTT CAAGCGATTC TCCTGTCTCA GCCTCCTGAG TAGCTGGGAT TACAGGCGCG 1620 TGGCACCACC CCCAGCTAAT TTTTGTATTT TTAGTAGAGA CGGGGTTTCA CCATGTTGGT 1680 CAGGCTGGTC TCGAACTCCT GACCTTGTGA TCTGCCCACC TTGGCCTCCC AAAGTGCTGG 1740 GATTACAGGC ATGAGCCACC ACGCCCGGCC CCCATGGTTT TTCAAATAGT TTAGAATTTC 1800 ATTTCCAGGT AACTAATTTG CTTCTTTAAA CATATGTCTT TTCTATTTAA GAAATCCTTT 1860 CTAAACAATT GCATTTTATT CCACAACCGC CTTCAAACAA TCATTGAGAC TTGGTTAATC 1920 TGTTTTGCTC ATTTGGCAGC AGTTTCTTGT GGCTGTTTCT TCCCTCCACT GGAGTCCTTG 1980 AATCTTAAGT CTGTCATTTG ACTGCAATTA AAAGCTGGGT TTGGAATACA ATCGCAGCCT 2-040 TACCATCCAC CTGCTGTGTG ACCTGGTAAA TTTCTTTTTT TTTTTTTGAG ACGGAGTCTT 2100 GCTCTGTTGC CCAGGCTGGA GTGCAGTGGC ACAACCTCTG CCTCCCAGGT TCAAGCGATT 2160 CTACTGCCTC AGGCTCCCTA GTAGCTGGGA TTATAGGTGC CTGCCACCAT GCCCAGCTGA 2220 TTTTTGTATT TTTAGTAGAG ATGAGGTTTC ACCATGTTGG CTAGGCTGGT CTCGAACTTC 2280 TGATCTTGTG ATCTGCCCGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG CATGAGCCAC 2340 CACTCCCAGC CAGTTCTTTT TTTCTTTTTT CCATTTTTTT TTTTTTCGAG ACAGGATCTT 2400 ACTCTTTTGC CCAGGCGGGA GTGCAGTGGC ACAATCACGG CTCAGCGCAG CCACTGCCTA 2460 CTGGGCTCAC ACGCTCCTCC GGCCTCAGCC TCTCGAGTAC CTGGGACTAC AAGCGTGAGC 2520 CAGTTTGGCT AATTTTGGCT AATTTTTGTA GAAACGGGGT CTCGCCATGT TGGCCAGGCT 2580 GGTCTCCAAC TCCTGGACTC AAGGGATCCA CCTTCCTCCC CCTCTCAAAG TTCTGGGATT 2640 ACCGGAGTGA GCCACTGTGC CCTGCTGGCA AATTTCTTAA ACTGTCTGTG CCTCAGTGAC 2700 CTCATTTAAT AAAGGGAATA ATTGTAGCAC ACTTTTTCTA GAGCTGTGAA GATTCAATGG 2760 AATAAATAAG GCAATAAATG AATGGATGGG GAATGAAGGA TGTGGGTTTC CTCCCTCTTG 2820 TCTTTCAATA AGCTCTCACC ATCAACCTCC CATTGCCTGT TCTCTCTCTT CCCCCTCTCT 2880 CCCTCTGTCT CTCTCTCAGC CAGGAAACCT GGGGTAGGGA GGCTTGGAGC CAGCGGGTGC 2940 GTCGGGAGGC TGCGGGTACT GACTCGGGCC GCGCACGGAG ATCGCGGGAG AAGGATCCAC 3000 AACCGCGGAA GAAGGATCAG GGTGGAGCCT GTGGCTGCTG CAGGAGGAGG AACCCGCCGC 3060 CTGGCCCACA CCACAGGAGA AGGGCGGAGC AGATGGCACC CTGCCCACCG CTTCCCGCCC 3120 ACGCACTTTA GCCTGCAGCG GGGCGGAGCG TGAAAAATAG CTCGTGCTCC TCGGCCGACT 3180 CTGCAGTGCG ACGGCGGTGC TTCCAGACGC TCCGCCCCAC GTCGCATGCG CCCCGGGAAC 3240 GCGTGGGGCG GAGCTTCCGG AGGCCCCGCC CTGCTGCCGA CCCTGTGGAG CGGAGGGTGA 3300 AGCCTCCGGA TGCCAGTCCC TCATCGCTGG CCCGGTCGCG CTGTGGCGAA GGGGGCGGAG 3360 CCTGCACCCG CCCCGCCCCC CCTCGCCCCG TCCGCCCCGC GCCGCGCGGG GAGGAGGAGG 3420 AGGAGCCGCG GCGGGGCCCG CACTGCAGCG CCAGCGTCCG AGCGGGCGGC CGAGCTCCCG 3480 GAGCGGCCTG GCCCCGAGCC CCGAGCGGGC GTCGCTCAGC AGCAGGTCGC GGCCGCAGCC 3540 CCATCCAGCC CGCGCCCGCC ATGCCGTCCG CGGGCCCCGC CTGAGCTGCG GCCTCCGCGC 3600 GCGGGCGGGC CTGGGGACGG CGGGGCCATG CGCGCGCTGC CCTAACGATG CCGCCCGCCG 3660 CGCCCGCCCG CCTGGCGCTG GCCCTGGGCC TGGGCCTGTG GCTCGGGGCG CTGGCGGGGG 3720 GCCCCGGGCG CGGCTGCGGG CCCTGCGAGC CCCCCTGCCT CTGCGGCCCA GCGCCCGGCG 3780 CCGCCTGCCG CGTCAACTGC TCGGGCCGCG GGCTGCGGAC GCTCGGTCCC GCGCTGCGCA 3840 TCCCCGCGGA CGCCACAGCG CTGTGAGTAG CGGGCCCAGC GGCACCCGGG AGAGGCCGCG 3900 GGACGGGCGG GCGTGGGCGG GTTCCCTGGC CCGGGACGGG AAGCAGGACG CGGGCCAGGA 3960 CGCTCCCAGG GGCGAGGCTC CGGCGCGGCA CGGCGGGCCC TGCTAAATAA GGAACGCCTG 4020 GAGCCGCGGT TGGCACGGCC CCGGGGAGCC GAAAAACCCC GGGTCTGGAG ACAGACGTCC 4080 CACCCGGGGG CTCTGCAGAC GCCAGCGGGG GCGGGGCGCG GAGGCCGCGC TCAGCTGGGA 4140 GGACAAACAG TCGCTAATTG GAGAGGAATT GGGATGCGGC CTGGGGCTGC GGGGTACCCG 4200 GAGAGGTGGG GATGGCTGTA GGGGGCGGCA GGGAAGAGTT CCAGGAGGTG TCTGGAAAAG 4260 GATTTGATGG ATGTGCAAGA ATTGGGCTGA TGCTTAGGAA GGGGCGATGA GGTGGGTCCA 4320 GAAGAAGGGG GGTGAACGGT GTGAGCAAAG ACCGTGAGGC TGGAGGCTGG CCACGGGAGG 4380 TGTGAGGGGT AGGGGCAGGG TGGGAGGTGG GCTCGCGGGT GGGCTGGGGT CATGAAGGGC 4440 CTCAGGCGCT CTGCTATTGG GTTCCAAGGC TATCCTGAGA ACAGGGGTGA GGGGGGATTG 4500 CCGTGGGGGG TTAAAGCCTT GTCATGTTCG CTTTCGGGAG ATAAAAACAA CAGGTGGCCT 4560 TTATGGAGAC GCTGCCCAGA GCCAGGTCTG TGCCAGGCTC CTGTTGGGGG TCGTCATGCG 4620 GAATCCTGAC TCTGACCATC CGAGGCATAG GGACCGTGGA GATTTGCATT TCACAGATGA 4680 GGAAACAGGT TTGGAGAGGT GACACGACCT GTCCCAGGCA TCACAGCCGG GATGTGCATA 4740 GCAGGGGTTT GGAACTATGA GGTGCCCAGG ACCCAGGGTT GGATTGAAAA GGGCGGAGGG 4800 GACTAAGATA AGCAGACAGT TGTCCCCAGC GCTGGGGAGA GTCTTGGGAC CAGTCTGATG 4860 CCTTGTATTT CCCAGGCTCC AGGCTCCTCG CCGGGACAGT GTCTCCTTGG GTGCGTGCTG 4920 GATCCCTGGG GGACGTGGCA CATCCCCAGG CTTGCTAAAC ATTGGGTGGG TTCTGGCATT 4980 TGGTTTTGTA ACGTTTCTGG GTCACTCCCG CCTGTGGCCA CCCTTCCTTA GGGGAGCCGT 5040 GTGTCCTTGG GGCTTTGCTG GGTGGTCTCG AGGGTGGGAG AAGAATGGGT TCTCCTGGAC 5100 CAATGGAGCC CGTGCCCCTC GGGGCCACAT TGCTCCTGCG CTCCCTGACT GCGGACGCGT 5160 GTGTCTCGCG GCTGTCTCTG TGGAGATGGC CTCCTCCTGC CTGGCAACAG CACCCACAGA 5220 ATTGCATCAG ACCTACCCCA CCCGTTGTTT GTGATGCTGT AGCTGAGGGC TCCTCTGTCT 5280 GCCAGGCCGG TCACTGGGGA CTCTGTCCAG GGCCTGGTGG TTCCTGCTTC CCAGCACCTG 5340 ATGGTGTCCA TGAGAGCAGC CCCTCAGGAG CTGTCCGGGA GAGAAGGGCG CTGGTGGCTG 5400 CTGAGCGGAG AGCAAGGCCC GTGTTCTCCA GGCCCTTGGC ACAGCAGTGG AGCCCCCGCC 5460 CCTGCCTTGT GTTGTCCTCT TAGGCTCTGG TCCTGGGGTT TGGAGGAGGG GGACCCTGGG 5520 AGTTGGTGGC CTGTCCCAGC CTGAGCTGGC AAGATTCCGA ATGCCAGGCC CCCCAAGTGT 5580 GCAACAGGGC ACAGGGTGAC CTCATGTGGG CAGGTGGGTG CTGTTCTGTA CACACCTGGG 5640 GCCGCCGCTG GGAGAGTTCT GGAAGGTGGG GTGAGGGGAC CCATGGCAAA CTAGGGCCTT 5700 AGGAAGGATG TGAAGGCCCT GGCTGGCCCC CCAGGCCACC CTCTGTGCTG TGGGGCAGCC 5760 CAGCCATTTT GCTGTCTACC CTGCAAACTC CTCCTCGGGG AGACGGCTGG GTTTTCCCCA 5820 GGGAAGAGGG GTCAAGCTGG GAGAGGTGAA GGACACAGAT CACAGCTGCT GGCAGGTGTT 5880 CAAGGGTCCA AGAGCGTTGC TGTCTGGGTG TCACCAGTAG CCTTCCTGGG GGGCTCACGC 5940 AGGTGCCTCT CCACTTGTGG CTCCCTGGCT GCTGAAGCTC AGCAGGGACA GCTGTGTCCA 6000 GTTCCAGGTG GAGGACAGCC GGGGCTTCTG AGGCCACAGC CTGCCTTGGG TTAATGATGC 6060 TGCCGAGAGG TGGTGGCTTT TGGAAAAGAT GGCGTACTGC AAAACGTGCT GCTCTGCGTG 6120 GCTCGAAGCT TCGTGGGGAG ACGTGGGCAG AGCCGTGGCT GACTCACAGA CCCCCCACCC 6180 CAGAGCCTGC CCTGCCCTCC CTGCCCCGAC CCTTCTCCCT CCTGACCCAT GTGTTTTTTT 6240 TTTTTTTTTT TTTTTTTGAG ACAGAGTTCA CTCTTGTTGC CAAGGCTGGA GTGCAATGGC 6300 ACGATCTCGG CTCATGGCAA CCTCCGCCTC CTGGGTTCAA GCGCTTTTTC CTGCCTCAGC 6360 CTCCCGAGTA GCTGGGATTA CAGGCGTGCA CCACCATGCC TGGCTAATTT TGTATTTTTA 6420 GTAGAGACAG GGTTTCTCCA TATTGGTCAG GCTGGTCTTG AACTCCTGAC CTCAGATGAT 6480 CCGCCCGCCT CGGCCTCCCA AAGTGCTGGG ATTACAGGCA TGAGCCACCA CGCCCAGCCC 6540 TGACCCATGT TTTGAACCAA ATTCCAGCCA CCCTTTTATC TGCAAGCATT TTGGAGGGCA 6600 TCGCAATACT GCAGACCCAC CTAACACAAC AGACAGTTCC TTCATGCCAC CGAAGGCCTG 6660 GTGTGTTCAC ATTTTTGGTT TAATAGTTTG AATTAAGAGC CAAATAAGGT CCACACACTG 6720 CAATTAGTTG ATGTCTTTTT TTTTTTCTTT TTTTTTTTTT TTTTGAGACG GAGTCTTGCT 6780 CTTGTCTCCA GGCCGCAGTG CAGTGGCATG ATCTCAGCTC ACCGCAACCT CCGACTCCCT 6840 GGTTCAAGCG ATTCTCCTGC CTCAGCCTCC CGAGTACCTG GTAGCTGGGT TTACAGGCAT 6900 GCACCACCGT GCCCAGCTAA TTTTTGTATT TTTAGTAGAG ACGGGGTTTT ACTGTGTTGG 6960 CCAGGATGGT CTCGATCTCC TGACCTCGTG ATCTGCCCAC CTCGGCCTCC CAAAGTGCTG 7020 GGATTACAGG CGTGAGCCAC CGCACCCGGC CAATGTCTTT TAAAAATATA TACTTTTTTT 7080 TTTTTTTTGA GACGGAGTTT CGCTCTTGTT GCCCAGGCTG GAGTGCAGTG GCGCGATCTC 7140 ACCTCACGGC AACCTCCGCC TCCCGGGTTC AAGTGATTCT CCTGCCTCAG CCTCTCCAGT 7200 AGCTGGGATT ACAGGCATGT GCCACCATGC CTGGCTAATT TTGTATTTTT AGGAGAGACG 7260 GGGTTTCTCC ACGTTGGTCA GGCTGGTCTC AAACTCCTGA CCTCAGGTGA TCCGCCTGCC 7320 TTGGCCTCCC AAAGTGTTGG GATTACAGGT GTGAGCCAAC GCGCCCAGAC AAAAATATAT 7380 GTGTGTCTTT AAGGCTGGTC AAGCAAAGCA GTAGGACTGG AGAAAGAATG AAGAATTCTA 7440 CCTGGCTGTG ATCAATTCGT TGTGAACACC ACTGTGCTTG GACCAGCTAG CTGATGTCTT 7500 TTGTTTTGTT TTGTTTGAGA CGGAGTCTGG CTCTGTCACC CAGGCTGGAG GACAATGGTG 7560 TGATCTCGGC TCACTGCAGC CTCCATCTCC CGGGTTCAAG CGATTCTCCT GCCTCAGCCT 7620 CCTGAGTAGC TGGGATTAGA GGCGCGCGCC ACCACGCCCG GCTAATTTTT AAAAATATTT 7680 TTAGTAGAGA TGGGGTTTCA CCATGTTGGT CAGGCTGGTC TTGAACTCTT GGCCTTAGGT 7740 GATCTGCTTG CCTCGGCCTC CCAAAGTGCT GGGATTACAG GTGTGAGTGA TGTATTTTAT 7800 TTATTTATTT ATTTATTTAT TTTTATTATT TGAGATGGAG TCTCACTCTG TTGCCCAGGC 7860 TGGAGTGCAG CAGTGCCATC TCAGCTCACT GCAAGCTCCG CCTCCTGGGT TCACGCCATT 7920 CTCCTGCCTC AGCCTCCTGA GTAGCCTGGA CTGGTGCCCG CCACCATGCC CAGCTAATTT 7980 TTTGTATTTT TAGTAGAGAC GGGGTTTCAC CGTGTTAGCC AGGATGGTCT GGATCTCCTG 8040 ACCTCGTGAT CCTCCCGCCT CAGCCTCCCA AAGTGCTGGG ATTACAGGCT TGAGCCACCG 8100 CCTGTCTTTT AAATGTCCGA TGATGTCTAG GAGCTTCCCT TCCTCTCTTT TTCCTTGTGC 8160 AATTTGTTGA AGAAACTGGC TCCTGCAGCC TGGATTTCTC GCTGTGTCTT GGGGGTGCCA 8220 CCTCCATGGT GTCACCTCCG TGGTGCTGTG AGTGTGTGCT TTGTGTTTCT TGTAAATTGG 8280 TCGTTGGAGC CGACATCCCA TTGTCCCAGA GGTTGTCCTG GCTGGCACTG GCCTAGGTGT 8340 AGATGTCATC AGCTCAGGGC CCCCTGCTCT AAAGGCCACT TCTGGTGCTG GTTGCCACTC 8400 ACCCTGGCTG GGGGTCACCT GGGTCTGCTG CTGTCTCGCA AATGCTGGGG TCCAGGACTG 8460 GGCACATCGA GGGACTTGGT AGGTGCTTGG TTCACTGATG TAAAATATAG GAGCACCCGG 8520 GGCCTTGCCC TTTCCCACCT GCATCCCTGA ATGACAGGAG AGTGTGGGAG AGTGTAGGGA 8580 CAGCAGGCGC AGACCCCGGG GCCCCTGCCT GGGATTGGCG TCGGGGAAGA CAGGCATTCT 8640 GGAGCGACCC CTAGGCCTGA TGCCTTAGAG CGCAACTGCC AGAGACACAG CTTCCTTGGG 8700 GGGCTGGCCA GGCCACGGAG GGGCCCTGGC TCCCATTTCT GGTCCCTGGA TCCTGAGAGC 8760 GAGGACTAGG GATTGTCACC AAGGCCTCCA TGAGCCCTCA GCAGAAGGAG GGCCACCCTC 8820 GAGGGCTCCG TTATCACTGG AGCCCGCGTT CAACCAACAC GCAGATGATT CTCCAAGGAC 8880 AGAGATGGAT GATGGGGAGG GGGCTGGCCT GGAAGGACCC CCAGTGCAGG TGACATTGAA 8940 GCCAGGTTTC AAAGCTCCCA CAGGGAGCTG CCCAGAGAGA GTCCCCAAGG GGCAAGGTGA 9000 CTCGGGGGCA GGGGTAGGGC CTCTGTCAGG AGAGCCTAGG AGAGGCCTGT GTCTTCTAGG 9060 AAGAGCCCTG GCAGCCGAGC GGAGGCAGTG GTGAGGACCT GCATCCTGCA TGTCCAGCTG 9120 GCCTCACCCG GGGTCCCTGA GCCGGGTCTT ACGTGGCTCC CGCACTCGGG CGTTCAGAAC 9180 GTGCCTGCGT GAGAAACGGT AGTTTCTTTA TTAGACGCGG ATGCAAACTC GCCAAACTTG 9240 TGGACAAAAA T GT GGACAAG AAGTCACACG CTCACTCCTG TACGCGATTG CCGGCAGGGG 9300 TGGGGGAAGG GATGGGGAGG CTTTGGTTGT GTCTGCAGCA GTTGGGAATG TGGGGCACCC 9360 GAGCTCCCAC TGCAGAGGCG ACTGTGGAGA CAGAGAGCAC CTGCAGGTCA TCCATGCAGT 9420 ATCGGCTTGC ATCCAGATCA TACAGGGAAC ACTATGATTC AACAACAGAC AGGGACCCCG 9480 TTTAAACATG GACAAGGGGT CACTCACGCC TGGAATCCCA GCAGTTTGGG AGGCCAGGGT 9540 GGGTGGATCG CTTGAGCCCA GGAGTTTGAC ACCAGCCTGG GCAACAGGGT GAGACCCCGG 9600 TCTCTAAAAA ATAAAAGAAC ATTGGCCGGG CGTGGTGGTA TGCATCTGTG GTCCCAGCTA 9660 TTCAGGAGAC TGAGGTGGGA CATCACTTGA GCCGAGGAGG TCAAGGCTGC AGTGAGCTGT 9720 GATCACACCA CTGCACTCCA GGCTGGGTCA CAGAGCAAGA CCCTGTCTCA AAAAAAAAAA 9780 AAAAAAAAAA AAAAAATCAC AGGATCTGAA CAGAGATTTC TCCAAAGAAG ACGCACAGAT 9840 GGCCAACAGC GTGTGAGAAG ATGGTCGGCC TCATTAGTCA TGAGGGAAAC GTAAATCAAA 9900 ACCACTGTCC AGCCGGGCGC GGTGCCTCAC GCCTGTAATC CCAGCACTTT AGGAGAGCAG 9960 ATGGCTTGAG GCCAGGAGTT TGAGGCCAGC CTGGGCAACA TAGCGAGACC AATAAATAGA 10020 TATTAGTGGT GGCGCCTGTA GTCCCAGCTA GTTGGGAGGC TGAGGGGGGA GGATTCCCTG 10080 AGTCTATGAG GTTGAGACTG CAGTTAGCTG TGATGGTGCC ACTGCACTCC AGCCTGGGCG 10140 ACTAGGAAAC GGTCTTTAAA AAAAAAAAAA AAAAACAGGG TGGGCGCGGT GGTTCACGCC 10200 TGTAATCTCA GCACTTTGGG AGGCCAAGGT GGGGGGATCA CAAGGTCAGG AGTTTGTGAC 10260 CAGCCTGACC AACATGGTGA AACCCCGTTC TACTAAAAAT ACAAAAATTA GCGAGGTGTG 10320 GTCGTGGGCG CCTGTAATCC CAGCTAATTA GGAGGCTGAG GCAGGAGAAT CACTTGAACC 10380 CGGGAGGCGG AGGTTGCAGT GAGCCAATAT CACACCACTG CACTCTAGCC TGGTCAACAG 10440 AGCGAGACTC TGTCTCAAAA AAAAAAAATG CTGAGCGTGG TGGCGCATGC CTGTAGTCTC 10500 AGCTACTTTG GGGGCTGAGG CAGGAGAATC GCTTGAACCT GGGAGGCAGA GGTCGCAGTG 10560 AGGCAAGATT GCACCATTGC ACTCCAGCCT GGGAGACAGA GTGAAACTCT GTCTCAAAAA 10620 GAAAAGGTCT AGGAAGAGTC CGCACCCTCT CCCCGCGGTG GCCACGCCGG GCTCCGCGCT 10680 GAGCCCTCTG TGTTCTTGTC TCTCCATACC TCATCACGGC ACCGCAGGGT TGCAGCCACT 10740 CCTGGTCTCA TTTTACACAC CAGGAAATTG AGGCTCTTTG AGAAGCCGTG GTGATGATTT 10800 CATCAGCATG CTCTGGGGCA GACCCCTGCA GCCGCACAGG GTGCCTGGGG CCCACACTAG 10860 TGCCCTGGTT TATAGACAGA CAGAGGTGGC AGTGGCGCTT CCGAGTCGGG CTGCGATGTG 10920 CTTGCACTCC CCGAGGGGCT GAGGGGCCCT GCGCCCAGGT GCAGCTGCTT GGGTGCTGCC 10980 AGCCCCTCCC ACCTCTCCCT CCCTGCCAGC CCCTCCCACC TCTCCCTCCC TGCCAGCCCC 11040 TCCCACCTCT CCCTCCCTGC CAGCCCCTCC CACCTCTCCC TCCCTGCCAG CCCCTCCCAC 11100 CTCTCCCTCC CTGCCAGCCC CTCCCACCTC TCCCTCCCTG CCAGCCCCTC CCACCTCTCC 11160 CTCCCTGCCA GCCCCTCCCA CCTCTCCCTC CCTCCAGCCC CTCCCACCTC TCCCTCCCTG 11220 CCAGCCCCTC CCACCTCTCC CTCCCTGCCA GCCCCTCCCA CCTCTCCCTC CCTGCCAGCC 11280 CCTCCCACCT CTCCCTCCCT GCCAGCCCCT CCCACCTCTC CCTCCCTGCC AGCCCCTCCC 11340 ACCTCTCCCT CCCTGCCAGC CCCTCCCACC TCTCCCTCCC TGGCTCATCC CTGCTGTGTC 11400 CCTTCTCTCT AGTTTCCTGT TCAGTTTCAG GAAGGAGGCT GGGAACCCAG ATGTAGGGAA 11460 TTTGCGCCCT GGAGTCAGAC CTGGGTTCAC GTCCCAGCGC CTCCACCTCT GGTGTGACCT 11520 TGGTCCAGTC TCTCAGCCTC AGTTTCCTCA CCTGTAAAGT GGGCTCCATG ATTAGATGCA 11580 CCCTGCAGGG CAGTGTAGCA GTGACCTGGC TCAGCCACTG GCACCCCCAA CAATCATACC 11640 TTGTTAAAGT AGCTCTGTCG GTTCCCTCAG GGGTTCCGGG GGCCCATTCC CCTGTCCTCC 11700 ATGCACTGTG AGACCTGCCC TGCCACAGAG CAGAGTGTAA CAGCCTGAGG GTGAGAGCCA 11760 GACACTGTGC CTGTGCTTAG ACCAGACACT GGACGACGGG AGCCAGTGCA GCCTGGGCGG 11820 GTGGACTCCT ATGGACCCCT CAGCACCCAG CCTCGGTGCC TTCAGCGCAG GGCCGCGTGG 11880 CTGTGGGGGC TCACAAGACC CGGCCCACTC CTGCTTGTGC CTACATCTGG GTGTTTGCCC 11940 ATTGGTGCCT TTTGACGCGT TCTGGTGTGT GTGAGACGTG CGGGGCTGGG AAGTGTTGGC 12000 AGAGCCGCGA GTACCGTCCT CACTCCTTTT GTTCTTTTGA CGTAAGCTGG CGAGTGGCAC 12060 TGCCTGAGTT CCGCTCAGTG CCCGCCCTGA TGTGCGGACC CCGCTGCATT CTTGCTGTTA 12120 GGTGGTGGCG GTGTGCGCTG TCGCTGGTGG GCACCGAGAG TCTTTGGGAG CTTTGGGGAG 12180 GTTGTGCCAA GCCTGAGCCT CGACGTCCCC CTTCCCGGCT TTCTGTTGGC TCTTCTGAGG 12240 CCAGGGCATC TCTATGAGGG CCTCCTGCTG GAGCCGTCTC TGTGGATCTC CTCTGCCATC 12300 CTGGCCCATG AGTGGGTGAT GCGCTGGCCA CCATCTGGTG ACAGTGGCCG GGCACCGCTG 12360 CCAAATGTGG GTCCCGCATC TGCAAGCCCC TCCCTGGGTC CCCTAGGGTA TGGGGTGGTT 12420 CTGCCACTGC CCTCGCTCCC CCACCTTGGG GTGCCTCTCC CCCTGCTCGT GGGGGAGACC 12480 CTGCCTGGGA TCTGCTTTCC AGCAAGGAAT ATACTTTGGA GGGAGACACA CATGTTCTTT 12540 TCTGGAGCTC TGCAGTGGCC ACGGCAGCCC AGCCCGCCAA GCACCCTGGA ATGAAAACAT 12600 CCCGCTGCTG TCTGGGCCTG GCCTGCACTC TGCTGCCTGC GCTCCAGCTG GCTGAGGCCG 12660 GGCACGTCTG CGGGCACAGC AGCGGGGGCG CCACAGTCTC CCTGCAGAGT GAGCGCAGCT 12720 GGAAAATGCA GCTCACGCCC TTTCCCAGAA CACCTCGCTC TTCATGGCTT GGCAGCTGTC 12780 CTTGCCTAGG GGCCAGGGTG CCCAGGCACT GGTGGCAGGA GAAGGGCTAC ATCTGGGGCT 12840 GAGGCGGGCT GGGTCCTTTT CTCCCTGCAG CTCCCGAGGC CCAGCCCTGG CCCAGCCTGG 12900 CATTCCTGAC CTTAGCAGCG CCATGATCTG AAGACAGGCT GGCTTCTGTG AGGCCACCTC 12960 AGAAA GGGCT TTGTGCCCAG GCAGAGGCGG AAGCCAGCTC TTCCTTCTGG TTGAGGCAGG 13020 AATGAGGCCA GCGCTGGGCA AGCCCATGCC CAGGGAACGT CACAGCTGTG GGAGTACAGG 13080 GGCTCCGGGT TCTGAGCCCG TCCACTGTGC ATCGTGGCCC TGGCCTCAGG ATGGCTCGTA 13140 CCATCATTGG CTGTGCCCAC AGCCGAGTGG GTGATGGGAT TCCGGCTGCC CCGCTGGATC 13200 TGTGCTGCTG CCCTCTCCAG GGCACTGCTG TGCCCGCACA GCCGGGCGCA GATGGCCAGT 13260 TTGCTTGCCC CCCCCCCCAC CATCCTCTTC CTACCTTGGC TTCCTCCATT GACACACTGG 13320 ACCCTGCTGG CTGCCCGGGG AGGTGTTTGG GGGATGGTGT TGGGGGAGGA GGAGGGCCCC 13380 TTGAGCCTCA GTGTGCCCAT CAGGAGCGTA AGGTCAGTGC AGCACCTGCC CACACAGGCT 13440 GTGAAGGGTG GGAGTGGAGA GGGATGCAAG GGGGTCACAA CGCCTGGCTC CATGTCAGCT 13500 GCGTGCAGGG GCACCAGGAG CCGGCCCTCA TTCTCCCCTT GAACTGGAAG GGTGGCCCCG 13560 ACCCCAGCGG CAGGTAGCAT ACGTATGAAG CGCTCTCCTT CCTACACCCC ACAGGTGGGC 13620 TCGTCTCCAG ACGGCCCTTT TTGAGCTGGC TGTGTTTTTC CATCTGTGTA GGCAAGGACA 13680 TCGCAGACTC CCCTTTCTCA TCTCCCTCGT TCAGCCTCCG AGGCCGGAGT CTCCATCCCT 13740 GTGCCTGCCT GTGGGTCCCG GGAGGACCTG AGGCTGCCCA TGTCACCCCC GGCATCTCAT 13800 CCTGGGGACA GTTCAGCCGT GGGAGGGATC TGTAAGGACA GAATGCCGCT GAGCCTGGGG 13860 CTCCCCAGCT AGTCTCACAC CCCGTGTCTG GGACCCAGAG ACCCTCGTGC AGGGCTCTGT 13920 TGCTTGGGGC CTGGCAGCCT CGTCCTGTAT CAGAGGCTGC CACCCCCACC CCTCGTGGGG 13980 CCAGGGTTGT GGCCGGCCTC CCTGGCCCTC CCCATGGAAG TGGTAGGCGG AGCCAGCAGC 14040 CATCTGCCCA GCCCGGGGCT GCACTGTTTT TTTTCAAATG AGCACCGTCC CAAACTGCAG 14100 CCCGTTAATT TAAACAGGAT CATTTCCGGC CCTGGAAGCC GCCTCACTCT CCTTAAATAG 14160 AAAGGAGCAC AGCGCAGAGG GAAACAGATG AGGTCATGGC TCGGCTGGCC CAGCGAGGAA 14220 GGGGCCGCAG TGGGGGTGGC ACTGCCGCCT GTCCCCTGTC CTCTCCAGCG CCCACACTGC 14280 AGCCCATTTC CTCACCCTGG GCCTGCTCTC GGGAGGGACG GGCCTGGGGG TCCTCTTGCT 14340 GGGCGGAGGG GAACCAGCTC CTCCAGGAGA GGACGGGGCC TGGCAGGGGG CATGGGGCCT 14400 CCCTGGGTCT GGCGTCCTGT CCTGCCCCTG CCGAGGGAGG AGCGGTTACA TAAGCTCCGC 14460 AGGCGGCCCC TCCGAGCCGG TCCCCCCAGC CCAGTTTCCA GTGAGGCGGC CAGCGCGGGC 14520 GGGGGTGCCG GGCCTGGCGC ACACCCGCTG CTGACCACAC GTGTCTGGAA TGTGCAGATG 14580 TTTCTTTGGG GGCTCCGTCC GGCCCCCAGA CCCCACTCAG CATCTGGTCT GGGGAGTGGG 14640 CGCCTGGGGC ACTCAGCTCT GAGTGTGAGA CTCTGAGGCA GGTCTGGTTT GTCTGGGGCC 14700 ATTCCCTCTG CTGTGGATTG GGAGGGCCCC GGGAGCTGCC CCACACCCAG GGAAGTTCTC 14760 CTCAGTCCCA CTGTTGCATT CCCCGACCCC GGCTCCCCCG GCCCAGGAGC GCCTGTGGGG 14820 CAGAAGGCCC AGCCCCAAGA CTTCCCGGCC CTGCCAGCCT CAGGCTTCAC CCACCCTCGC 14880 GCCAACTGTG GGCAGAGCCC AGGGGGAGGG CAGGAGAGCC AGCGCCTGGC TGGGAACACC 14940 CCTGAGGGGC CGAGGCTCCA GGGCGAGGGG GCCCGACCTG GGGTTCACAC GCCCGGGTGG 15000 CGGGCAGACC CGCTGCAGCA TGAGACACGT GTCAGCTACC TCGGGCCGGC AGGCTGGCCC 15060 TGCTGCCCAC AGCCCTGGGA CGTGGCCCCA CCTGTGACGG GTGTGGAGGG GCAGCCTCCA 15120 GGCCTGGCCA CACCCTCTGC TGTTGCTGCT CCTGCTCCAG GATTGGCAAG GGTGCTGGGA 15180 AGGGGTGAAG ACCCGTACTG TGGCCACACA CCTGGGACTT CCTTCTCCAC CCAGTGGTGC 15240 CCCAGCAGCC GCTAAGGAGC CCGCTGGGTC CCACGCTAGG ATGGTCCTAA CTCCTCCCGC 15300 CTTCCAGATC GGACGCTCGG CGCTGGGGAC CCCTTGTGTC CCGGGGCTGG GGCACCGTCC 15360 TGCCCCCATG GGGGTGTACT CCTCCCGACA AGCTTGGCTT CAGCTTCCCT GGGAGCACAT 15420 CCTGGCCCTC GGGCACCCAT CAGGCTGTCC CTGTGCACCT GGCTCCCACC CTTCCAGCTC 15480 ATAGCAGGAA CTGGGGTGAG GAGTGCGTGG GGCAGCAAGG GCCTGGGACC CCAGAGGACC 15540 CTGCACTCTG CTCTGTGCTC TTGCCTGGGC TTAGGGCCGC TCGGTGGTCC TGCTGCCAGA 15600 TGCCTGGGCC CTGCTGTGTC CCCCATCCTT GCAGGGAACC AGAACGTGGG GGCAGGGCAT 15660 CAGACAGCGG CGATGATGTC ACCTGGCGGG TGCAGAGGAA GCCCGAGGGG CGGGGTGGGG 15720 GGGCTGGCGC GAGGCTGCCT GGCTAGGCCT TGGCGTTCCC CCAGAACGGC GATGGCAAAA 15780 GCAGATGGAG ACGTGAAAAA GTACGGGAGC AAGCGAGGTG AGGACTCCAC GGGGACCCCT 15840 GTGCTGTTCC CTGTCCCTGA AGCCCACACC TGAGTCCTGC CCAGGGCAGA TGCTTCCACA 15900 CCCAGGGGGC ACCTGAGTCC TACCCAGGGC AGACGCTTCC ACACCCTGGG GGCTGGGGGA 15960 CTGCACCTGG CTCCTGTCTG GGCCCCAGCT TCATTCCACT GCCCTGGGCC CTGGGAGCTC 16020 GGCCGAGCGG GGTCCCCAAG ACCTTGCTGC ATTTCTGGGC CTTGGGCTGG GGTGAGGGCC 16080 GGGAGAAGGA GCCAGCCTGG AGCCTGGCAC GCAGGGAGTG CATGGCCAGA ACCGGTGACA 16140 GGCAGGGCTG CCTGCTGGCG TGGAAGAAGT GTCCATGGCA CCCCCAGGCC TGGTTCACAG 16200 TGGGATGGGC GGGGAGCCGG GGGGCTCTGG GGTCCTCGGC TGACCTGCCC CCACCCCTGC 16260 CCTGGCTTGT CAGCTCCCAG CAGCAGCCAC TCTTGATGGA TTTTCCAGAA AATGAGGTGT 16320 GGCCAAACAT CTTCAGGCTT TTCCTTCTTT CCTTTCTCCC GTGGCCTGGG TGGGAGCTGC 16380 TCCCCATGCC TGGGGGCAGG TGCGAGAGCC TGTGCCCCTC CCTGGGGCAG TTTCACAGCT 16440 GTGTCCCTTC CAGGGGGCCT GCCTGTGTTC ACCGTGGCCT CTGCAGCACC TCTCGCCCCT 16500 TAGGGCTCCT GCGCCTCGGG TCCCGGTGCC TCATTTCTCC CTAAAGCATT GGTTCTGCTG 16560 CCGCCGCAGC CGCTGGAAAG TCCCTCCTCA GGTCTAACTG CAGTTCCTCA CGGCACAGTG 16620 TTCCCCCTCG GGCATGGTGC TTGGGCAGTG GGTGTGAGTC CAGCTGCCTC ACCCTGTCTC 16680 G A GA AT G GCC TCTTGCTGGT CTCCCAGCCA CCACCCTGTC CCACCCCACG GCGGGGATGG 16740 TGTGGATGCC TAGCAGCGCG GCTGTGGGCC CACCCATCCT TATGGGCAGT GGGGAGCACC 16800 TCAGCCCGTG TCCCTACCTT GGTGTAGAGG AGGGGACGGC AGAGAAGCAG GGTTCAGTTA 16860 GGGGGGAAGT GGTGGCCCTG CCGGAGGGGC CGTTCCCTGT GTGCCTGGCC CCCAGATCCT 16920 CTCCCCTCCC GGAGCCCAGG GCACAGGCAT AGGCTCTCTG AGTGTCCCAC AGCCCCTGGG 16980 GGAAGGGAAC TGCACCCCCA ACCGTGCCCT CCATCCGCAG ATGGAACGAG AAGCTCCGGG 17040 AGCCAGTGCC CAGCGTCTCA TCTGTCTGGG CACCCAGCCC AGGTGAGGGC CTGGCTCCAC 17100 CGTCCGTGGC TGGTGCTGCT TCCTGGCACG GAGAAGGCCT CGGCTGCTCT GTCCCCTCAG 17160 CTGGGGTGGC CTCTGGTCCC CTTCTTTGTT GGTTCCCTTC TCAAGCTCTT GCCCTGGCCC 17220 CGGGCCCCAC CGGGCAGCCT GTGTGTGCGT CTCTCCTGCG CCGGGTAGGC TCCTGTGGGA 17280 GCGGAGCTCC GGTGGGAGGA GCAGGGCTGG AGGCTGGCAG GGGCTGGGCG GGTGTTCAGG 17340 GATGGAGGCC GCCCCGGCTT GGGGCTGGCT GCCGGGTGGT CATTGCTGGG AAGAGCAAGT 17400 CTAGGCGGAG GCACCTGCTG GGTCACTCGT GGGGAGGGTG ACACCTGGGG AAGTAGAGGC 17460 CCGTGGCAGG AGGTGAGGCC TCGGGGTCCT GGGGAGCAGG GGGGTGGTGT GCAGACCTGC 17520 GGAGCCATAG TCCTGTGCCA GGAGCACTAC TGGGAGTGCG TGGGACCAGG AGGGGTGCCC 17580 AGGGTGGGCG GCAGAGTGAC CCCCGAGGTG CTTGAGGCCG AGGGGAGGTG GAGTTCTCGG 17640 TTTGCCCCAG CTCTCTGTCT ACTCACCTCC GCATCACCAG CTCCAGGACC TGGTTTGTAA 17700 CTCGGGCAGC TCTGAAAAGA GAGACATGCT GCCGCCCTGT GGTTTCTGTT GCTTTTTCTT 17760 CACTGACTAC TGACATGGGA TGTTTTTCCT ACGGCTGTGA CCAATTGTGC TTCTTCTAAT 17820 TGCCTGGTTT TTCTTTTTTT GTTTTTGGAG TTTTCTCTTT CTTTCCTCCC TCCCTCTCAC 17880 CCTCCATCCT TTTTTTTTTT ATTTTTATTT TTTGAGATGG AGCTTCACTC TTGCAGGATG 17940 GGGTGCTGGA GTGCAGGGGT GCGATCTCAG CTCACTGCAA CCTCTGCCTC GCGGGTTCAA 18000 GTGATTCTCC TGCCTAAGCC TCCTGAGTAG CTGGAATTAC AGGTGCTTGC CACCACGCCC 18060 GACTAATTCT GTAGTTTTGG TAGAGACAGG GTGTCTCCGT GTTGGTCGGT CTGGTCTTGA 18120 ACTCCTGACC TCAGGTGATG CGCCCGCCTC AGCCTCCCAA AGTGCTGGGA TTACAGGCAG 18180 GAGCCATTGC ACCCGGCTCT TTCCCCTTCT CCTTTTCTTC TCTCTCTCCT CCCTTTCTTT 18240 CTTTTCTTTT CTTTTTTTTT TCTTTTGAGA TGGAGTCTCG CTCTGTCACC AGGCTGGATT 18300 GCAGTGGCGT GATCTTGGCT CACTGCAACC TTCGCCTCCC GGGTTCACGT GATTCTCCTG 18360 CCTCAGCCTC CTGAGTGGCT GGCACTACAG GCTCCCGCCG CCATGCCCGG CTAATTTTTG 18420 CATTTTTAGT AGAGACAGGG TTTCACCCTG TTGGCCAGGA TGGTCTCGAT CTCTTGATCT 18480 CATGATCCAC CCACCTTGGC CTCCCAAAGT TCTGGCATTA CAGGAGTGAG CCACCGTGCC 18540 CGGCCATCTT TCTTTCCTTG CTTTCTCTTT GTTTTCTTTC GAGACCGGGT CTTGCTCTGT 18600 CGCCCAGGCT GGACTGCAGT GGCACAATCA TAGCTCACTG CAGCCTCGAC TTCCCTGGCT 18660 CAAGCGATCC TTCCTCCTCA GCCCCCCGAG TAGCTGGAAC TACAGTTACA CACTACCATG 18720 CCTGGCTGAT TCTTTTTTTC CTTGTAGAGA TGGGGTCTTG CTATGCTGTC CATCCTGGTC 18780 TCAAACTCCT GGCCTTCCCA AAGCACTGGG TTTACAGGCA TAAGCCACCA CACCCAGTTT 18840 CCTTTTCTTC TTTTTAACTG GAATAGTTGA CGTTTTCTTT ATTAGCTGTG TGTCAGGAGG 18900 GTATTTTTGG CCTTTAGTAT GTCGTGTAAG TTGCTAGTGC TTTTCTGAGA TTGTAGTTTG 18960 TTTTCTAATT TTATTTATAT TTTGCGTAGA AGTTGTGTAT TTTAGATGGA GTTAGGTCGG 19020 CTGGTCTTTG ATGTTTTATT TATTAATTAT GTATGTATTT ATTTATTTTT GAGGTAGAGT 19080 CTCGCCGTTT CACCCAGGCT GGAGTACAGT GATGCGATCT CAGCTCCCTG TAGCCTTGAC 19140 CTCTCTGGGC TCAAGTGATT TTTCTCTCCT CTACCTCCCG AGTACTTGGG ACCCCAGGCG 19200 CATGCCGCCA TGCCTGGCTA ATGTGTATTT TTTGTAGATA CGGGGTCTCA CTGTGTTGCC 19260 CAGGGTGGTT TCAAAATCCT GGGCCCAGGC GATCCTTCCG TCTCAGCTCC CACGGTGCTG 19320 TGTTACCGGC GTGTGCCCAG TGCCTGGCCG TCTTGGAGGT CTTGTTTCTC TGGGTTTATG 19380 CCTCGAGGTG GCGCCTGCTC CCCTGTGCTC CCTGGTAGCC TGGTAGTGAG CCTGCTTCTC 19440 ACACAGTCAT ACCTGGTTGT GGTCCCACAG TGGGACCACC CTGTTGGGTT CAGAACAGGA 19500 GATGGGGGCC CCTCGAGTCT GTGTGGGGGC TGTGGACAGG GTTGGGAGAC CTTGGCTCTG 19560 TGGGGGACTG TGGACAGGGG ATGGGGGGCC TTGGCCCTGC GTGGGATGGG TTGGGGGTCC 19620 GTGCCCTTCC TGGCCCTGGG TGGACAGGTC CATGTGGCAC TCGGCATAGG GCTGAGATGG 19680 GTGCAGAGGG CTGAGGCCCC CAGGCCTCTC CTGGCTTGGT TTCCCCAGAT GAGTGTTCAT 19740 TTGGGTCTTC CATCAGAAAG TCCCCTCCTG ACCTCTGGGA GTGGGGAGCT CAAGGGTGGG 19800 AGGCCATAGC TTGGGGATGC TGGCAATGTG TGGGATGGGC CCAGGGAAGG CCTCTGGCCT 19860 ACTAGGGGCT CTGGCCCTGA CCCACGGCCA CTCACTCCTC AGAGACGTCT CCCACAACCT 19920 GCTCCGGGCG CTGGACGTTG GGCTCCTGGC GAACCTCTCG GCGCTGGCAG AGCTGTGAGT 19980 GTCCCCCAGT CGTGCCAGCA TGCGGGGCTC ACTCCGGGTG GGCTGGCGGC ACCGCCTCTT 20040 GCTGCTCAGC TGTGGGGGCT TCCATCAGCT TTGCCGAATC CCCCGTCTCT TCCAGGGATA 20100 TAAGCAACAA CAAGATTTCT ACGTTAGAAG AAGGAATATT TGCTAATTTA TTTAATTTAA 20160 GTGAAATGTA AGTTGTGGTT CTTTGGGTGG GGTCCTGGCT GGACCCCAGG CCCCCAATAT 20220 CCCTTCTGCC CTCCCAGTTG GTCCGTGTCC CCTTCCAGGC TTGAGACCAG ATCCTGGGGG 20280 CAGTTCACTG CCTGCTTGGA GCCCCCCAGT GCCGGCTTGG TTGGGGCAGG GGAGGCGGTG 20340 CTGTCAGGGT GGCTCCAGGG CCTGGTTGCC AGTGGGGGGC TGGCATAGAC CCTTCCCACC 20400 AGACCTGGTC CCCAACACCT GCCCCTGCCC TGCAGAAACC TGAGTGGGAA CCCGTTTGAG 20460 TGTGACTGTG GCCTGGCGTG GCTGCCGCGA TGGGCGGAGG AGCAGCAGGT GCGGGTGGTG 20520 CAGCCCGAGG CAGCCACGTG TGCTGGGCCT GGCTCCCTGG CTGGCCAGCC TCTGCTTGGC 20580 ATCCCCTTGC TGGACAGTGG CTGTGGTGAG TGCCGGTGGG TGGGGCCAGC TCTGTCCTTC 20640 CCAGCCAGGT GGGACCTGGG CCCTGCAGAC ACTGGGCAGG GCTCAGGAAG GCCTCTCTGG 20700 GGGGGGCCTC CGGGCCAAGG GAACAGCATG GGAGCCTGTG AGTGCGGCGG GCGGATGTGG 20760 GGGCGTGGGG TGGAGCCAGG AGGAGCAGAA CCCGGGGTCC AGTGGCTGCC TCTTCTAGGT 20820 GAGGAGTATG TCGCCTGCCT CCCTGACAAC AGCTCAGGCA CCGTGGCAGC AGTGTCCTTT 20880 TCAGCTGCCC ACGAAGGCCT GCTTCAGCCA GAGGCCTGCA GCGCCTTCTG CTTCTCCACC 20940 GGCCAGGGCC TCGCAGCCCT CTCGGAGCAG GGCTGGTGCC TGTGTGGGGC GGCCCAGCCC 21000 TCCAGTGCCT CCTTTGCCTG CCTGTCCCTC TGCTCCGGCC CCCCGCCACC TCCTGCCCCC 21060 ACCTGTAGGG GCCCCACCCT CCTCCAGCAC GTCTTCCCTG CCTCCCCAGG GGCCACCCTG 21120 GTGGGGCCCC ACGGACCTCT GGCCTCTGGC CAGCTAGCAG CCTTCCACAT CGCTGCCCCG 21180 CTCCCTGTCA CTGCCACACG CTGGGACTTC GGAGACGGCT CCGCCGAGGT GGATGCCGCT 21240 GGGCCGGCTG CCTCGCATCG CTATGTGCTG CCTGGGCGCT ATCACGTGAC GGCCGTGCTG 21300 GCCCTGGGGG CCGGCTCAGC CCTGCTGGGG ACAGACGTGC AGGTGGAAGC GGCACCTGCC 21360 GCCCTGGAGC TCGTGTGCCC GTCCTCGGTG CAGAGTGACG AGAGCCTCGA CCTCAGCATC 21420 CAGAACCGCG GTGGTTCAGG CCTGGAGGCC GCCTACAGCA TCGTGGCCCT GGGCGAGGAG 21480 CCGGCCCGAG GTGAGTGTCT GCTGCCCACT CCCCTTCCTC CCCAGGGCCA TCCAGATGGG 21540 GCAGAGCCTG GTACCCCCGT CTTGGGCCCA CACTGACCGT TGACACCCTC GTTCCCACCG 21600 GTCTCCAGCG GTGCACCCGC TCTGCCCCTC GGACACGGAG ATCTTCCCTG GCAACGGGCA 21660 CTGCTACCGC CTGGTGGTGG AGAAGGCGGC CTGGCTGCAG GCGCAGGAGC AGTGTCAGGC 21720 CTGGGCCGGG GCCGCCCTGG CAATGGTGGA CAGTCCCGCC GTGCAGCGCT TCCTGGTCTC 21780 CCGGGTCACC AGGTGCCTGC CCCCACCCCC CGAGGGGCCA TAGGTTGGGA GATCTCTGAA 21840 GCACTGGGGC AGAGACTGCG GCTGGGGAGT CTCAGGAGGA AGGAGGTGGG AGCTGGGCCG 21900 GCCCTGGTGA GCAGGTGGCG CCGGCCGGTG GGGCCGTTCC TGTCAGCTCT GCAGATGCAG 21960 AGGTGGACAT GAGCTGGGGG CAGCCTCCGG ACACTCCTGG GCACGCCATA CGGGAGGTGG 22020 CCTGCACGGG GATCCCTGCC GGTACCCACA GGCCCCGTGG GTGGGTGCTG CTGTGAGCCT 22080 GGGCTGGTGG GCCCTGGTCT CCGGGCTCTG AGCCTCAGTT TCCCCATCTG GAAAGGGGGA 22140 CAGTGATGGG GCTCCCAGCG GGCTGCTGTG AGGGTGGGAG GATGGAGGAG TGCCCTGAGC 22200 CCCCTGCCAT CCCACACCCG CCCCCAGGAG CCTAGACGTG TGGATCGGCT TCTCGACTGT 22260 GCAGGGGGTG GAGGTGGGCC CAGCGCCGCA GGGCGAGGCC TTCAGCCTGG AGAGCTGCCA 22320 GAACTGGCTG CCCGGGGAGC CACACCCAGC CACAGCCGAG CACTGCGTCC GGCTCGGGCC 22380 CACCGGGTGG TGTAACACCG ACCTGTGCTC AGCGCCGCAC AGCTACGTCT GCGAGCTGCA 22440 GCCCGGAGGT GTGCGGGGGG CCAGGCAGGG GCCTGAGACG CTGGCTGTGG TTAGGGGCCT 22500 GCCGAGCGCC CGCGGTGGAG CCTGGGCTGA GGAGGAGGGG CTGGTGGGGG GGTTTTCGGG 22560 CGGCTCGGTC CCCAGTCTGT TCGTCCTGGT GTCCTGGGCC CTGGCCCGGC GCCTCACTGT 22620 GCACTCGCCA CCCCAGGCCC AGTGCAGGAT GCCGAGAACC TCCTCGTGGG AGCGCCCAGT 22680 GGGGACCTGC AGGGACCCCT GACGCCTCTG GCACAGCAGG ACGGCCTCTC AGCCCCGCAC 22740 GAGCCCGTGG AGGTAGTCGG CCCCCCACGT TCTACAACCT GCCCTCCTGC CTGCCCCTGG 22800 AGGCCTTGCC TGCCCTGCCC ACTGTGGGTC TCGCCAAAAA ACTTGGGGGC CTTAATGTTG 22860 CTTGTGCCCA GTGAAGATGG TTGGGAAAAT CCAGAGTGCA GAGAGGAAAG CGTTTACTCA 22920 CATTACCTCC AGGCCTTTTC TCTGAGCGTG TGTGAGTTAT TCCTGAAAGG CAGGTCAGGG 22980 GTCCTGCCCC CCATGGACAG TTTCCACCGG AGTCTTCCTC TCGAGCGACA GGAGCCAGGC 23040 CTGTGGGGGT CTGATGGCTC GCTCTCCTTC CCTCCCCTCT TCCTGGGAAG TTCGGGTAGG 23100 GGGAGTCTGG GCTTCAGGCT GGGATGGGGT CTGTGGAGCT GAGGCGGCCC CCTGCCCACC 23160 AGGTCATGGT ATTCCCGGGC CTGCGTCTGA GCCGTGAAGC CTTCCTCACC ACGGCCGAAT 23220 TTGGGACCCA GGAGCTCCGG CGGCCCGCCC AGCTGCGGCT GCAGGTGTAC CGGCTCCTCA 23280 GCACAGCAGG TGGGACTCTG GGTGGTGGGT GGTGGGTGGT GGGCGCCGCA GGACTCGGGG 23340 TGGCCTCTCT GAGCTTTCAC GTCTGCTGGT CCTGTGGCCA CCAGAGTGGT TCCCAGTCTT 23400 AGGTGGACAG AGCAGGGGTT CCAGAGACAC CAGCTCATTC CAGGTGTCCT GGGGGTGGAT 23460 TGGGTGGGGC CTGCCTGGGG GCCGGCCTGG GTCAGTCGGC TGGCCGGAGA CGGACGCAGC 23520 ACTGGGCTGG GAGTGCTGCC CAGGTGGGGA GACCTGTCCT CACAGCAAGG CCAGGATTGC 23580 TGGTGCAGGC AGTTGGGCAT CTCTGACGGT GGCCTGTGGG CAAATCAGGG CCCCAACACC 23640 CTCCCCTCCT CACAGGGACC CCGGAGAACG GCAGCGAGCC TGAGAGCAGG TCCCCGGACA 23700 ACAGGACCCA GCTGGCCCCC GCGTGCATGC CAGGGGGACG CTGGTGCCCT GGAGCCAACA 23760 TCTGCTTGCC GCTGGACGCC TCCTGCCACC CCCAGGCCTG CGCCAATGGC TGCACGTCAG 23820 GGCCAGGGCT ACCCGGGGCC CCCTATGCGC TATGGAGAGA GTTCCTCTTC TCCGTTCCCG 23880 CGGGGCCCCC CGCGCAGTAC TCGGTGTGTG GCCCTGACCT GGGTCTGTTC CCTGCATCTC 23940 CTCAGGCCAC CTTCCTGTCT GCTGCCCAGG GTCTGGGTCT GTGCACCAGA CACACCCAGC 24000 CTGCAGGCCC CTCCCACGTC CTTGCCACCT CTGACCTCCG ACCTCTGCAG TGCCCTCGGC 24060 CCTCTCCCAG TGGGAGAAGC TCTCGCCTGG GCCCTTGGCA CGAGCTGTGC CTCCTCTTCC 24120 TCTCTCCCAG CACAGCTGCT CCTTCCTGTC TGCCAGGTCT TGGCCTGTGT CCTCTCCCCG 24180 TGTGTCCCCC GGTCTGCAAC TGTCCTGCCT GTCCTTGTCA CGAGCACTGT GGGGAGGCTC 24240 CTTGAGGTGT GGCTGACGAA GCGGGGAGCC CTGCGTGTCC ACCCTCATCC GTCGTGCGGG 24300 GGTCCACGGG CCATGACCGT GAGGACGTGA TGCAGCCCTG CCTCCCTCTC CACAGGTCAC 24360 CCTCCACGGC CAGGATGTCC TCATGCTCCC TGGTGACCTC GTTGGCTTGC AGCACGACGC 24420 TGGCCCTGGC GCCCTCCTGC ACTGCTCGCC GGCTCCCGGC CACCCTGGTC CCCGGGCCCC 24480 GTACCTCTCC GCCAACGCCT CGTCATGGCT GCCCCACTTG CCAGCCCAGC TGGAGGGCAC 24540 TTGGGCCTGC CCTGCCTGTG CCCTGCGGCT GCTTGCAGCC ACGGAACAGC TCACCGTGCT 24600 GCTGGGCTTG AGGCCCAACC CTGGACTGCG GCTGCCTGGG CGCTATGAGG TCCGGGCAGA 24660 GGTGGGCAAT GGCGTGTCCA GGCACAACCT CTCCTGCAGC TTTGACGTGG TCTCCCCAGT 24720 GGCTGGGCTG CGGGTCATCT ACCCTGCCCC CCGCGACGGC CGCCTCTACG TGCCCACCAA 24780 CGGCTCAGCC TTGGTGCTCC AGGTGGACTC TGGTGCCAAC GCCACGGCCA CGGCTCGCTG 24840 GCCTGGGGGC AGTGTCAGCG CCCGCTTTGA GAATGTCTGC CCTGCCCTGG TGGCCACCTT 24900 CGTGCCCGGC TGCCCCTGGG AGACCAACGA TACCCTGTTC TCAGTGGTAG CACTGCCGTG 24960 GCTCAGTGAG GGGGAGCACG TGGTGGACGT GGTGGTGGAA AACAGCGCCA GCCGGGCCAA 25020 CCTCAGCCTG CGGGTGACGG CGGAGGAGCC CATCTGTGGC CTCCGCGCCA CGCCCAGCCC 25080 CGAGGCCCGT GTACTGCAGG GAGTCCTAGT GGTGAGTATG GCCGAGGCTC CACCACCAGC 25140 CCCCAGGCAG GTGCCTGCAG ACAGGGTGCT CACACAGGGC GTGAGGCCTG GCTTCCCAGT 25200 GAGGGCAGCA GCCCAGTTAC TGGGGACGTC GGCCCCGGGC AGGTCCTGCT GGCTGGCTCC 25260 TCGGGCTACC TGGTGGGCTT TAAATTCCTG GAAAGTCACG GCTCTGACAG TGGCTCCGCT 25320 AACTCATTCC ACTGTCTCAT TTCACAAAAT GAATTTAAAA CTCTGCTCCC TGACCTCACA 25380 CGAGCCCCCG TGAGTCTCTC ACGCCCTCTG CTGTGTTCTC GCCTGGCTAA AGCGAGTGGC 25440 TTTTGAGGTG GAGTCTGAAC CCCTGATGGG AAACTGCGGG CTGCCCGCGG TGCCACCATG 25500 CTGGGTACAT GGGGGACAGG GCTGTCTCCA TCTTGCGGGT ACCTGCCTCT TCACCAGGGG 25560 CCTTGGGAGG GGCCATCAGA AATGGCGTGA CCTGTGCAGC CTGTCCTGGG TTCTGTAAGC 25620 CAGTGTAGGT GCCTCCCCTC ACTGCTCCGA GCTCTCTGGG TGAGGAGCTG GGGCAAGAGC 25680 GCCGGGAGGG TCTGAGAAGA CTCAGAGAGA GGTGGACTCT TTGTAGCTGG TACTAGGTTT 25740 GCTTTACAGA TGGGGAAACT GAGGCACAGA GAGGTTGAGG CATTAGTAGT ACTACATGGC 25800 TGGCTGGAGA GCCGGACAGT GAGTGTCCCA GCCCGGGCTT GGCTCCCATG GCATGCAGAG 25860 CCCCGGGCAC CTCCTCTCCT CTGTGCCCCG CGTGGGACTC TCCAGCCCGA CGGGAGGTGT 25920 GTCCAGGAGG CGACAGGCTA AGGGCAGAGT CCTCCACAGA GCCCAGGCTG ACACCATTCC 25980 CCCCGCAGAG GTACAGCCCC GTGGTGGAGG CCGGCTCGGA CATGGTCTTC CGGTGGACCA 26040 TCAACGACAA GCAGTCCCTG ACCTTCCAGA ACGTGGTCTT CAATGTCATT TATCAGAGCG 26100 CGGCGGTCTT CAAGCTCTCA GTAGGTGGGC GGGGGTGGGG AGGGGAGGGG ATGGGGCGGG 26160 GCAGGGCGGG GGCGGGCTCC ACCTTCACCT CTGCCTTCTG CTCTGCTTCA TGCTGCCCGA 26220 GGACGCTGCC ATGGCTGTGG GTGAGTGGAG GGAGGGACGC CAATCAGGGC CAGGCCTCTC 26280 ACCTGCCACC TGGGCTCACT GACGCCTGTC CCTGCAGCTG ACGGCCTCCA ACCACGTGAG 26340 CAACGTCACC GTGAACTACA ACGTAACCGT GGAGCGGATG AACAGGATGC AGGGTCTGCA 26400 GGTCTCCACA GTGCCGGCCG TGCTGTCCCC CAATGCCACG CTAGCACTGA CGGCGGGCGT 26460 GCTGGTGGAC TCGGCCGTGG AGGTGGCCTT CCTGTGAGTG ACTCGGGGGC CGGTTTGGGG 26520 TGGGCACCAG GCTCTTGTCC CAGCCCCAGC CTCAGCCGAG GGACCCCCAC ATCACGGGGT 26580 TGCTTTTCTG AGCCTCGGTT TCCCTGTCTG TTGGGAGGTA ACTGGGTGCA CAGGAGCCCT 26640 GAGGCTGCAC GGGAGCCGGG AGAGGCCTCA GCACAGCCGG GTGGGCCCTG AATGGAGGCC 26700 CGGGGCGTGA CTGCAGAGTG GAGCCTCGGC TGGGTCCCAA GCACCCCCTG CCCCGCCACC 26760 GCCCACCCCT GTCCCGGTTC ACTCACTGCG TCCCACCGCC CCGGCAGGTG GACCTTTGGG 26820 GATGGGGAGC AGGCCCTCCA CCAGTTCCAG CCTCCGTACA ACGAGTCCTT CCCGGTTCCA 26880 GACCCCTCGG TGGCCCAGGT GCTGGTGGAG CACAATGTCA TGCACACCTA CGCTGCCCCA 26940 GGTGAGGGAT GAGGGGGTGA GGGGGCCACT GCCTTTCAGG CTCTGAGCAC GGGTCCCCCC 27000 AGCTCCCCAG TCAAGCTGCC CCCCTTCCTC CCCAACAGCC CTCACTGTGA CCTCACCTGG 27060 GCTGATGGCT TAGGCCCTAC TGGGGTGAGG GAGGGGCCAG GCGTGGGGGG AGTGGACAGG 27120 GAAGCTGGGC CCCTGAACTG CGCCCCCCGC CCTCCCCGGG CCTGGCTCTT GCTGCTCTGC 27180 TGCCCCGAGT GCAGCTGCAC TTGGAGGCGG TGCCGTCCTC GCCAGGCAGC CCTCAGTGCT 27240 GCTACACCTG TGCTCCGTCC CGCACGTGGC TTGGGAGCCT GGGACCCTTA AGGCTGGGCC 27300 GCAGGTGCAG CCGTTCACCC CGGGCTCCTC AGGCGGGGGG CTTCTGCCGA GCGGGTGGGG 27360 AGCAGGTGGG GGTGCCGCGG CTGCCCCACT CGGGCCTGTC CCCACAGGTG AGTACCTCCT 27420 GACCGTGCTG GCATCTAATG CCTTCGAGAA CCTGACGCAG CAGGTGCCTG TGAGCGTGCG 27480 CGCCTCCCTG CCCTCCGTGG CTGTGGGTGT GAGTGACGGC GTCCTGGTGG CCGGCCGGCC 27540 CGTCACCTTC TACCCGCACC CGCTGCCCTC GCCTGGGGGT GTTCTTTACA CGTGGGACTT 27600 CGGGGACGGC TCCCCTGTCC TGACCCAGAG CCAGCCGGCT GCCAACCACA CCTATGCCTC 27660 GAGGGGCACC TACCACGTGC GCCTGGAGGT CAACAACACG GTGAGCGGTG CGGCGGCCCA 27720 GGCGGATGTG CGCGTCTTTG AGGAGCTCCG CGGACTCAGC GTGGACATGA GCCTGGCCGT 27780 GGAGCAGGGC GCCCCCGTGG TGGTCAGCGC CGCGGTGCAG ACGGGCGACA ACATCACGTG 27840 GACCTTCGAC ATGGGGGACG GCACCGTGCT GTCGGGCCCG GAGGCAACAG TGGAGCATGT 27900 GTACCTGCGG GCACAGAACT GCACAGTGAC CGTGGGTGCG GCCAGCCCCG CCGGCCACCT 27960 GGCCCGGAGC CTGCACGTGC TGGTCTTCGT CCTGGAGGTG CTGCGCGTTG AACCCGCCGC 28020 CTGCATCCCC ACGCAGCCTG ACGCGCGGCT CACGGCCTAC GTCACCGGGA ACCCGGCCCA 28080 CTACCTCTTC GACTGGACCT TCGGGGATGG CTCCTCCAAC ACGACCGTGC GGGGGTGCCC 28140 GACGGTGACA CACAACTTCA CGCGGAGCGG CACGTTCCCC CTGGCGCTGG TGCTGTCCAG 28200 CCGCGTGAAC AGGGCGCATT ACTTCACCAG CATCTGCGTG GAGCCAGAGG TGGGCAACGT 28260 CACCCTGCAG CCAGAGAGGC AGTTTGTGCA GCTCGGGGAC GAGGCCTGGC TGGTGGCATG 28320 TGCCTGGCCC CCGTTCCCCT ACCGCTACAC CTGGGACTTT GGCACCGAGG AAGCCGCCCC 28380 CACCCGTGCC AGGGGCCCTG AGGTGACGTT CATCTACCGA GACCCAGGCT CCTATCTTGT 28440 GACAGTCACC GCGTCCAACA ACATCTCTGC TGCCAATGAC TCAGCCCTGG TGGAGGTGCA 28500 GGAGCCCGTG CTGGTCACCA GCATCAAGGT CAATGGCTCC CTTGGGCTGG AGCTGCAGCA 28560 GCCGTACCTG TTCTCTGCTG TGGGCCGTGG GCGCCCCGCC AGCTACCTGT GGGATCTGGG 28620 GGACGGTGGG TGGCTCGAGG GTCCGGAGGT CACCCACGCT TACAACAGCA CAGGTGACTT 28680 CACCGTTAGG GTGGCCGGCT GGAATGAGGT GAGCCGCAGC GAGGCCTGGC TCAATGTGAC 28740 GGTGAAGCGG CGCGTGCGGG GGCTCGTCGT CAATGCAAGC CGCACGGTGG TGCCCCTGAA 28800 TGGGAGCGTG AGCTTCAGCA CGTCGCTGGA GGCCGGCAGT GATGTGCGCT ATTCCTGGGT 28860 GCTCTGTGAC CGCTGCACGC CCATCCCTGG GGGTCCTACC ATCTCTTACA CCTTCCGCTC 28920 CGTGGGCACC TTCAATATCA TCGTCACGGC TGAGAACGAG GTGGGCTCCG CCCAGGACAG 28980 CATCTTCGTC TATGTCCTGC AGCTCATAGA GGGGCTGCAG GTGGTGGGCG GTGGCCGCTA 29040 CTTCCCCACC AACCACACGG TACAGCTGCA GGCCGTGGTT AGGGATGGCA CCAACGTCTC 29100 CTACAGCTGG ACTGCCTGGA GGGACAGGGG CCCGGCCCTG GCCGGCAGCG GCAAAGGCTT 29160 CTCGCTCACC GTGCTCGAGG CCGGCACCTA CCATGTGCAG CTGCGGGCCA CCAACATGCT 29220 GGGCAGCGCC TGGGCCGACT GCACCATGGA CTTCGTGGAG CCTGTGGGGT GGCTGATGGT 29280 GGCCGCCTCC CCGAACCCAG CTGCCGTCAA CACAAGCGTC ACCCTCAGTG CCGAGCTGGC 29340 TGGTGGCAGT GGTGTCGTAT ACACTTGGTC CTTGGAGGAG GGGCTGAGCT GGGAGACCTC 29400 CGAGCCATTT ACCACCCATA GCTTCCCCAC ACCCGGCCTG CACTTGGTCA CCATGACGGC 29460 AGGGAACCCG CTGGGCTCAG CCAACGCCAC CGTGGAAGTG GATGTGCAGG TGCCTGTGAG 29520 TGGCCTCAGC ATCAGGGCCA GCGAGCCCGG AGGCAGCTTC GTGGCGGCCG GGTCCTCTGT 29580 GCCCTTTTGG GGGCAGCTGG CCACGGGCAC CAATGTGAGC TGGTGCTGGG CTGTGCCCGG 29640 CGGCAGCAGC AAGCGTGGCC CTCATGTCAC CATGGTCTTC CCGGATGCTG GCACCTTCTC 29700 CATCCGGCTC AATGCCTCCA ACGCAGTCAG CTGGGTCTCA GCCACGTACA ACCTCACGGC 29760 GGAGGAGCCC ATCGTGGGCC TGGTGCTGTG GGCCAGCAGC AAGGTGGTGG CGCCCGGGCA 29820 GCTGGTCCAT TTTCAGATCC TGCTGGCTGC CGGCTCAGCT GTCACCTTCC GCCTGCAGGT 29880 CGGCGGGGCC AACCCCGAGG TGCTCCCCGG GCCCCGTTTC TCCCACAGCT TCCCCCGCGT 29940 CGGAGACCAC GTGGTGAGCG TGCGGGGCAA AAACCACGTG AGCTGGGCCC AGGCGCAGGT 30000 GCGCATCGTG GTGCTGGAGG CCGTGAGTGG GCTGCAGGTG CCCAACTGCT GCGAGCCTGG 30060 CATCGCCACG GGCACTGAGA GGAACTTCAC AGCCCGCGTG CAGCGCGGCT CTCGGGTCGC 30120 CTACGCCTGG TACTTCTCGC TGCAGAAGGT CCAGGGCGAC TCGCTGGTCA TCCTGTCGGG 30180 CCGCGACGTC ACCTACACGC CCGTGGCCGC GGGGCTGTTG GAGATCCAGG TGCGCGCCTT 30240 CAACGCCCTG GGCAGTGAGA ACCGCACGCT GGTGCTGGAG GTTCAGGACG CCGTCCAGTA 30300 TGTGGCCCTG CAGAGCGGCC CCTGCTTCAC CAACCGCTCG GCGCAGTTTG AGGCCGCCAC 30360 CAGCCCCAGC CCCCGGCGTG TGGCCTACCA CTGGGACTTT GGGGATGGGT CGCCAGGGCA 30420 GGACACAGAT GAGCCCAGGG CCGAGCACTC CTACCTGAGG CCTGGGGACT ACCGCGTGCA 30480 GGTGAACGCC TCCAACCTGG TGAGCTTCTT CGTGGCGCAG GCCACGGTGA CCGTCCAGGT 30540 GCTGGCCTGC CGGGAGCCGG AGGTGGACGT GGTCCTGCCC CTGCAGGTGC TGATGCGGCG 30600 ATCACAGCGC AACTACTTGG AGGCCCACGT TGACCTGCGC GACTGCGTCA CCTACCAGAC 30660 TGAGTACCGC TGGGAGGTGT ATCGCACCGC CAGCTGCCAG CGGCCGGGGC GCCCAGCGCG 30720 TGTGGCCCTG CCCGGCGTGG ACGTGAGCCG GCCTCGGCTG GTGCTGCCGC GGCTGGCGCT 30780 GCCTGTGGGG CACTACTGCT TTGTGTTTGT CGTGTCATTT GGGGACACGC CACTGACACA 30840 GAGCATCCAG GCCAATGTGA CGGTGGCCCC CGAGCGCCTG GTGCCCATCA TTGAGGGTGG 30900 CTCATACCGC GTGTGGTCAG ACACACGGGA CCTGGTGCTG GATGGGAGCG AGTCCTACGA 30960 CCCCAACCTG GAGGACGGCG ACCAGACGCC GCTCAGTTTC CACTGGGCCT GTGTGGCTTC 31020 GACACAGGTC AGTGCGTGGC AGGGCCGTCC TCCATGCCCC TCACCCGTCC ACACCCATGA 31080 GCCCAGAGAA CACCCAGCTT GCCACCAGGG CTGGCCCGTC CTCAGTGCCT GGTGGGCCCC 31140 GTCCCAGCAT GGGGAGGGGG TCTCCCGCGC TGTCTCCTGG GCCGGGCTCT GCTTTAAAAC 31200 TGGATGGGGC TCTCAGGCCA CGTCGCCCCT TGTTCTCGGC CTGCAGAGGG AGGCTGGCGG 31260 GTGTGCGCTG AACTTTGGGC CCCGCGGGAG CAGCACGGTC ACCATTCCAC GGGAGCGGCT 31320 GGCGGCTGGC GTGGAGTACA CCTTCAGCCT GACCGTGTGG AAGGCCGGCC GCAAGGAGGA 31380 GGCCACCAAC CAGACGGTGG GTGCCGCCCG CCCCTCGGCC ACTTGCCTTG GACAGCCCAG 31440 CCTCCCTGGT CATCTACTGT TTTCCGTGTT TTAGTGCTGG TGGAGGCCGC ACGCTCTCCC 31500 CTCTCTGTTT CTGATGCAAA TTCTATGTAA CACGACAGCC TGCTTCAGCT TTGCTTCCTT 31560 CCAAACCTGC CACAGTTCCA CGTACAGTCT TCAAGCCACΛ TATGCTCTAG TGGCAAAAGC 31620 TACACAGTCC CCTAGCAATA CCAACAGTGA GGAAGAGCCC CTTCCCACCC CAGAGGTAGC 31680 CACTGTCCCC AGCCCATGTC CCTGTTGCTG GATGTGGTGG GCCGGTTCTC ACCCTCACGC 31740 TCCCCTCTCT GGACCGGCCA GGAGGCTTGG TGACCCTGAG CCCGTGGTGG CTGCTCCTGC 31800 TGCTGTCAGG CGGGGCCTGC TGGTGCCCCA GAGTGGGCGT CTGTTCCCCA GTCCCTGCTT 31860 TCCTCAGCTG GCCTGATTGG GGGTCTTCCC AGAGGGGTCG TCTGAGGGGA GGGTGTGGGA 31920 GCAGGTTCCA TCCCAGCTCA GCCTCCTGAC CCAGGCCCTG GCTAAGGGCT GCAGGAGTCT 31980 GTGAGTCAGG CCTACGTGGC AGCTGCGGTC CTCACACCCA CACATACGTC TCTTCTCACA 32040 CGCATCCCCC CAGGGGCCCT CAGTGAGCAT TGCCTGCCTC CTGCTAGGGT CCAGCTGGGT 32100 CCAGTACACC AGAACGCACA CTCCAGTGTC CTCTGCCCTG TGTATGCCCT TCCGCCGTCC 32160 AAGTTGGAAG GTGGCAAACC GGATGAGTAT CCTGGGAGGG AGTGAGCTCA CCGGCAGTGG 32220 CCAGGCCCCT GGGAAACCTG GAGTTTGGGA GCAGCATCCT CCATGGGTCC CCCAGTCCTT 32280 CCAGCAGGCC AAATAGACCT GTGTTGGAGG TAACCCCACT CCCACGCCAG GTGCTGATCC 32340 GGAGTGGCCG GGTGCCCATT GTGTCCTTGG AGTGTGTGTC CTGCAAGGCA CAGGCCGTGT 32400 ACGAAGTGAG CCGCAGCTCC TACGTGTACT TGGAGGGCCG CTGCCTCAAT TGCAGCAGCG 32460 GCTCCAAGCG AGGGGTGAGT GTTGAGCGGG GTGTGGGCGG GCTGGGGATG GGTCCCATGG 32520 CCGAGGGGAC GGGGCCTGCA GGCAGAAGTG GGGCTGACAG GGCAGAGGGT TGCGCCCCCT 32580 CACCACCCCT TCTGCCTGCA GCGGTGGGCT GCACGTACGT TCAGCAACAA GACGCTGGTG 32640 CTGGATGAGA CCACCACATC CACGGGCAGT GCAGGCATGC GACTGGTGCT GCGGCGGGGC 32700 GTGCTGCGGG ACGGCGAGGG ATACACCTTC ACGCTCACGG TGCTGGGCCG CTCTGGCGAG 32760 GAGGAGGGCT GCGCCTCCAT CCGCCTGTCC CCCAACCGCC CGCCGCTGGG GGGCTCTTGC 32820 CGCCTCTTCC CACTGGGCGC TGTGCACGCC CTCACCACCA AGGTGCACTT CGAATGCACG 32880 GGTGAGTGCA GGCCTGCGTG GGGGGAGCAG CGGGATCCCC CGACTCTGTG ACGTCACGGA 32940 GCCCTCCCGT GATGCCGTGG GGACCGTCCC TCAGGCTGGC ATGACGCGGA GGATGCTGGC 33000 GCCCCGCTGG TGTACGCCCT GCTGCTGCGG CGCTGTCGCC AGGGCCACTG CGAGGAGTTC 33060 TGTGTCTACA AGGGCAGCCT CTCCAGCTAC GGAGCCGTGC TGCCCCCGGG TTTCAGGCCA 33120 CACTTCGAGG TGGGCCTGGC CGTGGTGGTG CAGGACCAGC TGGGAGCCGC TGTGGTCGCC 33180 CTCAACAGGT GAGCCAGGCC GTGGGAGGGC GCCCCCGAGA CTGCCACCTG CTCACCACCC 33240 CCTCTGCTCG TAGGTCTTTG GCCATCACCC TCCCAGAGCC CAACGGCAGC GCAACGGGGC 33300 TCACAGTCTG GCTGCACGGG CTCACCGCTA GTGTGCTCCC AGGGCTGCTG CGGCAGGCCG 33360 ATCCCCAGCA CGTCATCGAG TACTCGTTGG CCCTGGTCAC CGTGCTGAAC GAGGTGAGTG 33420 CAGCCTGGGA GGGGACGTCA CATCTGCTGC ATGCGTGCTT GGGACCAAGA CCTGTACCCC 33480 TGCCTGGAGC TTTGCAGAGG GCTCATCCCG GGCCCCAGAG ATAAATCCCA GTGACCCTGA 33540 AGCAGCACCC CGACCTTCCG CTCCCAGCAG CCACACCCAC CGGGCCCTCT CCGGCGTCTG 33600 CTTTCCACAA TGCAGCCCCC GCCCAGGAGG GCCCATGTGC TTACCCTGTT TTGCCCATGA 33660 AGAAACAGCT CAGTGTTGTG GGTCAGTGCC CGCATCACAC AGCGTCTAGC ACGTAACTGC 33720 ACCCCGGGAG TCGTGGGCAT CTGCTGGCCT CCTGCCGGCC TCCTGCGCTG CTGACAGCTT 33780 GCTGTGCCCC CTGCCTGCCC CAGTACGAGC GGGCCCTGGA CGTGGCGGCA GAGCCCAAGC 33840 ACGAGCGGCA GCACCGAGCC CAGATACGCA AGAACATCAC GGAGACTCTG GTGTCCCTGA 33900 GGGTCCACAC TGTGGATGAC ATCCAGCAGA TCGCTGCTGC GCTGGCCCAG TGCATGGTAG 33960 GATGGCCCCA CCTGCTCACC CTGCCCCGCA TGCCTGCCAG GGCACTGGGT TCAGCCCCCC 34020 AGGGCAGACG GGCAGCTTGG CCGAGGAGCT GAGCCTCCAG CCTGGGCTCC TTCCTGCCAT 34080 GGCGTTCCTC GGTCTCTGAC CTGCTTCAGT AGCCTCAGCC GTTCTGTCCT GTGTGAACGC 34140 AGGGTGCCTC TCGGGGGACC CAGGGTGTAA AGAGGGGCCC AGATGTGGGG AGGGACTAAG 34200 AAGATGCTGC TCTGTGCCCT CCACTCTCCC CTCCCCTCCC CTCCCCCTTC CCTCCCCTAG 34260 CCCCTCCCCT CCTCCCCTCC CCTAGCCCTT CCCCTCCTCC CCTCCCCTAG CCCTTTCCCT 34320 TCTTCCCCCC CAGCCCTTCC CCTCCTCCCC TCCCCTAGCC CTTCCCCTCC TCCCCTCCCC 34380 TACCCCTTCC CCTCCTCCCC TCCCCTAGAC CTTCCCCTCA CCTCCTCCCG CTGAGCCCCT 34440 CCACTCGTCC CCCAGCCCCT CCCTCCCCTA GCCCCTCCCC TCCCCCTTCC TCCCCTCCTC 34500 CCCCTCCCCT CCTCCCCCTC CCTCTTCCTC CCCCTCCCCT CCTCCCCCTT CCTCCCCTCT 34560 CCTCCCCCTC CCCTCCTGTC CCCCCTCCTC CCCTCCTCCC TCCTCCCCTC CTCCCCCCTC 34620 CTCCTCCCCC TCCTCCCTCC TCCCTCCTCC CCCTCCTCCT CCTCCCCTCC TCCCTCCTCC 34680 CCTCCTCCCC TCCCCTCCTC CCCCTCCCCC CTCCCTTCCT CCCCCTCCCC CCTCCCCTCC 34740 TCCCCCTCTC CTCCTCCCAT CCCTCCTCCC ATCCCTCCTC CCCGTTCCCA TTCTCTCCCC 34800 TCCCCCTTCC ATTTCTCCCT CCTCCCCCTC CCCTCCTCTC CTCCTCACCT CCCCTTCTCC 34860 GCTCCTTTCT TCTCCTCCCT CCCTTTCTCT CCTCCCTCCC CTTCTCCCCT TCTCCTCTTC 34920 TCCCCTTCTC CTCTCTTTTC ATCCTTCCCT TCTTCCCTCC TTTCCTCCTC TTTTCCCTCT 34980 TCTCCCCCCT CCTCCCCTCC TTCCTCCTCC CATTCCCCCT CCTCCCCCCT CCCATTCCCC 35040 CTCCTCCCCT CCTTCCTCCT CCCATTACCC CTCCTCTCCT CCCCTCCTCC CACCCCCCTC 35100 TCCTCCCGGC TCCTCTCCTC CCCTCCTCAT CCCCCTCCTC TCCTTCCCTC CTAACCCCCC 35160 TCCTCTCCTC CCCTCCTCAT CCCCCTCCTC TCCTTCCCTC CTCCTATCCC CCCTCCTCTC 35220 CTCCCCTCCT CCTATTCCCC CTCCTCTCCT CCCCTCCTTC CTCCTCCTCT CCTCCCATGC 35280 CCCCTCCTCC CCTCCTCCCA TCCCCCTCCT CCCCTCCTCC CTCCTCCCAT CCCATCCCCC 35340 TCCTCTCCTC CCCTTCTCTC CCCTCCTCTC CTCCCCTCCT CTCCTCTCCT CCTCTCCTCC 35400 CCTCCTCCCA TCCCCCCTCC TCCCATCCCC CCTCCTCTCC TCCCCACTCC TCTCCTCCCC 35460 ACTCCTCTCC TCCCCTCATC CCCCTCCTCT CTCCTCCCCT CCCCCTCCTC TCCTTCCCTC 35520 CTCCTTTCCT CCCCTCCCCC TCCTTCCCCC TCCTCCCCCT CCTTCTCCCC ATCCCCCTTC 35580 CCCTTCTCCT CCTCTCCCCT CCCCCTTCTC TTTTTCCCTC CTCCTCCCTT CCTCCTCCCC 35640 TCTTCTCCCC TTTTCCCTTT TCTCTTCCTC TCCTCCCCTT CTCCCCTCCT GTCCTCCCTC 35700 CCTTTCTCTC TTTCTTTCCT CCCTTTCCTT CTCCCCTGTT CTCCTCCCTT CCCTTCTCCC 35760 CTTTTCTTCC CTCCTCCTTT CCTCCCCTCC TCCTTTTCTC TGTTTCTCTT CCTTTCCCCT 35820 CCACTTTCCC CTTCCTTTCC CCTCTCCTTT CTCCTTCCTT TCCTCTCCCC TTCTCTTCCT 35880 TTTCCTCTCT CCCCTTCTTT TCCCTCTTCC CCTCCCCTCC TCTTCCCCTC CCCTCCTCTT 35940 CCCCTCCCCT CCTCTTCCCC TCCCCTCCTC TTCCCCTCTC CTCCTCTTCC CCTCCCCTCC 36000 TCTTTCCCTC CCCTCTTCTC CTCCCCTCCT CTCCCCTCTT CCCCTCCCCT CCTCTTCCCT 36060 CCCCTTCCCC TCCCCTCCTC TTCCCTCCCC TTCCCCTCCC CTCCTCTTCC CTCCCCTTCC 36120 CCTCCTCTTC CTTCCTCTCT TCCCCTCCCC TCCTCTTCCC TCCCCTCTTC CCCTCCCCTT 36180 CTCTTCTCCT CCCCTTCTCT TCCCCTCCCC TTTTCTTCCC TCTCCTTGTC TTCCCTGCCC 36240 TCCTCTTCCC TCCCCTCCTC TTCCCTCCCC TCTTCCCCTC TCCTCCTCTT CCCTCCCCTC 36300 TTCCTCTTTC CTCTTCCCCT CCCCTCCTCC TCCCTCCCCT TTCCCCTCTT CCCCTCCCCT 36360 CCGCTTCCCT CCCCTTTCTC CCCCTTCTCT CCCCTCCCCT CTCCCCCCTT CTCTCCCCTC 36420 CCCTCTCCCC CTTCTCTCCC CTCCCCTCTC CCCCTTCTCT CCCCTCTCCT CTCCCCCTTC 36480 TCTCCCCCTT CTCTCCCCCT TCTCTCTCCC CTTCTCTCCC CCTTCTCTCC CCTCCCCCCT 36540 TCTCTCCCCT CCCCTCTCCC CCTTCTCTCC CCTCCCCTCT CCCCTGTCCT CTCCTCTCCA 36600 CCCTTCTCTC CCCTCCCCTC TCCTCTCCCC CTTCCCTCTC CTCTCCCCCT TCTCTCCCCT 36660 CCCCTCTCCT CTCCCCCCTT TTCTCCACTC CCCTCTCCTC TCTCCCCTCC TCCTCCGCTC 36720 TCATGTGAAG AGGTGCCTTG TGTGGTCGGT GGGCTGCATC ACGTGGTCCC CAGGTGGAGG 36780 CCCTGGGTCA TGCAGAGCCA CAGAAAATGC TTAGTGAGGA GGCTGTGGGG GTCCAGTCAA 36840 GTGGGCTCTC CAGCTGCAGG GCTGGGGGTG GGAGCCAGGT GAGGACCCGT GTAGAGAGGA 36900 GGGCGTGTGC AAGGAGTGGG GCCAGGAGCG GGGCTGGACA CTGCTGGCTC CACACAGGGG 36960 CCCAGCAGGG AGCTCGTATG CCGCTCGTGC CTGAAGCAGA CGCTGCACAA GCTGGAGGCC 37020 ATGATGCTCA TCCTGCAGGC AGAGACCACC GCGGGCACCG TGACGCCCAC CGCCATCGGA 37080 GACAGCATCC TCAACATCAC AGGTGCCGCG GCCCGTGCCC CATGCCACCC GCCCGCCCCG 37140 TGCGGCCCTT TCCTCTGCCT CCCTCCTCCC CCCAACCGCG TCGCCTTTGC CCCATCCCAT 37200 CTTCGTCCCC CTCCCCTCCC CCCAATTCCC ATCCTCATCC CCCTCCCCCA ATTCCCATTC 37260 TCCTCCCCCT CCCCCTTCCC TATTACCATC CCTTTTCTCC ATCTCTCTCC CCTTTTCTCC 37320 ATTTCCCCCC CCGTCCTCCC CGTCCTTTTG TCCATTCCCC TCATCTTCCT CATCCCCCTC 37380 ATCCCCCTTC CCCTCCCTTA TCCCCCTTCC CCTCCCTTTC CCCCTGCTCC TCTTCTTCTC 37440 CCTTCTCTTT TCTCTACCCT TTTCCTTCCT TTTTCCTCCC TCTCCCCATC ATCCCCCTCA 37500 TCTTCGTCCT CATCCCCATC ACCTTCCCCC TCCCCCCTCC ACCACTCTCT CTCCAGCTTC 37560 CCCCTTCCTT CTGCCTGCAC CTCGCTCTCT GCCCCCTCAG GTTCCCCCTT TCTCCCAGCC 37620 CCCACCCTCC GGCTCCCCCT TTTTGCCTGC CCCCACCCTC CCTCTACCTC CCTGTCTCTG 37680 CACTGACCTC ACGCATGTCT GCAGGAGACC TCATCCACCT GGCCAGCTCG GACGTGCGGG 37740 CACCACAGCC CTCAGAGCTG GGAGCCGAGT CACCATCTCG GATGGTGGCG TCCCAGGCCT 37800 ACAACCTGAC CTCTCCCCTC ATGCGCATCC TCATGCGCTC CCGCGTGCTC AACGAGGAGC 37860 CCCTGACGCT GGCGGGCGAG GAGATCGTGG CCCAGGGCAA GCGCTCGGAC CCGCGGAGCC 37920 TGCTGTGCTA TGGCGGCGCC CCAGGGCCTG GCTGCCACTT CTCCATCCCC GAGGCTTTCA 37980 GCGGGGCCCT GGCCAACCTC AGTGACGTGG TGCAGCTCAT CTTTCTGGTG GACTCCAATC 38040 CCTTTCCCTT TGGCTATATC AGCAACTACA CCGTCTCCAC CAAGGTGGCC TCGATGGCAT 38100 TCCAGACACA GGCCGGCGCC CAGATCCCCA TCGAGCGGCT GGCCTCAGAG CGCGCCATCA 38160 CCGTGAAGGT GCCCAACAAC TCGGACTGGG CTGCCCGGGG CCACCGCAGC TCCGCCAACT 38220 CCGCCAACTC CGTTGTGGTC CAGCCCCAGG CCTCCGTCGG TGCTGTGGTC ACCCTGGACA 38280 GCAGCAACCC TGCGGCCGGG CTGCATCTGC AGCTCAACTA TACGCTGCTG GACGGTGCGT 38340 GCAGCGGGTG GGGCACACGC GGCCCCCTGG CCTTGTTCTT GGGGGGAAGG CGTTTCTCGT 38400 AGGGCTTCCA TGGGTGTCTC TGGTGAAATT TGCTTTCTGT TTCATGGGCT GCTGGGGGCC 38460 TGGCCAGAGA GGAGCTGGGG GCCACGGAGA AGCAGGTGCC AGCTCTGGTG CAGAGGCTCC 38520 TATGCTTTCA GGCCCGTGGC AGAGGGTGGG CTCAGGAGGG CCATCGTGGG TGTCCCCCGG 38580 GTGGTTGAGC TTCCCGGCAG GCGTGTGACC TGCGCGTTCT GCCCCAGGCC ACTACCTGTC 38640 TGAGGAACCT GAGCCCTACC TGGCAGTCTA CCTACACTCG GAGCCCCGGC CCAATGAGCA 38700 CAACTGCTCG GCTAGCAGGA GGATCCGCCC AGAGTCACTC CAGGGTGCTG ACCACCGGCC 38760 CTACACCTTC TTCATTTCCC CGGGGTGAGC TCTGCGGGCC AGCCTGGCAG GGCAGGGCAG 38820 GGCATCATGG GTCAGCATTG CCTGGGTTAC TGGCCCCATG GGGACGGCAG GCAGCGAGGG 38880 GACTGGACCG GGTATGGGCT CTGAGACTGC GACATCCAAC CTGGCGGAGC CTGGGCTCAC 38940 GTCCGCTACC CCTTCCCTGC CCAGGAGCAG AGACCCAGCG GGGAGTTACC ATCTGAACCT 39000 CT CC AGCCAC TTCCGCTGGT CGGCGCTGCA GGTGTCCGTG GGCCTGTACA CGTCCCTGTG 39060 CCAGTACTTC AGCGAGGAGG ACATGGTGTG GCGGACAGAG GGGCTGCTGC CCCTGGAGGA 39120 GACCTCGCCC CGCCAGGCCG TCTGCCTCAC CCGCCACCTC ACCGCCTTCG GCGCCAGCCT 39180 CTTCGTGCCC CCAAGCCATG TCCGCTTTGT GTTTCCTGTG AGTGACCCTG TGCTCCTGGG 39240 AGCCTCTGCA GAGTCGAGGA GGGCCTGGGT GGGCTCGGCT CTATCCTGAG AAGGCACAGC 39300 TTGCACGTGA CCTCCTGGGC CCGGCGGCTG TGTCCTCACA GGAGCCGACA GCGGATGTAA 39360 ACTACATCGT CATGCTGACA TGTGCTGTGT GCCTGGTGAC CTACATGGTC ATGGCCGCCA 39420 TCCTGCACAA GCTGGACCAG TTGGATGCCA GCCGGGGCCG CGCCATCCCT TTCTGTGGGC 39480 AGCGGGGCCG CTTCAAGTAC GAGATCCTCG TCAAGACAGG CTGGGGCCGG GGCTCAGGTG 39540 AGGGGCGCAG CGGGGTGGCA GGGCCTCCCC TGCTCTCACT GGCTGTGCTG GTTGCACCCT 39600 CTGGGAGTGA GTCTCGTCGC AGGCGTCAGA ACAAGGCAGT TTTTGCAGTG CTGTGTGAAG 39660 GGCTCGTGTG TTCATCCTGG GAATGACCTC GTGAGCACTC ACTGTCCCTG AGGACTAGGA 39720 CAGCTCCTAG CTGGAAGTAG GTGCCAGTCA GTCAGGGTGG GCAGCCCACG TTCTGCACAG 39780 TAGCGTGGCC CCACAAGTGA CGTGAGCATC GCTACCACTG TGGGAGACTG TGCATCCACC 39840 CGCGATCCTG ACTGCATAGC TCGTCTCTCA GACGGAGGCG CCAGCACCCT CCCCGTGGCT 39900 GTTTCTTCAG TACCTCCATT TTCCTTTCAT TGGAATTGCC CTTCTGGCAT TCCCTTTTTG 39960 TTTTCGTTTT TCTTTTTTTA GAGACGGAGT CTCACTCTGT TGCCCAGGCT GGAGTGCAAT 40020 GGCATGATCT TGGCTCACAG CAACTTCCAG CTCCCGGGTT TAAGCCATTC CCCTTAAGCG 40080 ATTCTCCTGA GTAGCTGGGA GTACAGGTGC ACACCACCAC ACCCAGTTAA TTTTTCACCA 40140 TGTCAGCCAG GCGAACTCCT GACCTCAGGT GATCCGCCTG CCTCGGCCTG CCAGAGTGCT 40200 GGGATGACAG GTGTGAGCCA CCACACCTGG CTGTGTTCCC ATTTTTTATC TCTGTGCTGC 40260 TTTCCTCTTC ATTGCCCAGT TCTTTCTTTT GATTACCTAC TTTTAAAAAC TGTCGGCCGG 40320 GCGCGGTGGC TCACACCTGT AATCCGAGCA CTTTGGGAGG CCAGGCAGGC AAATCACGGG 40380 GTCAGGAGAT CGAGACCATC CTGGCTAACG GTGAAACCCT GTCTCTAATA AAAAGTACAA 40440 AAAAATTAGC CCGGCGTAGT GGCAGGCGCC TGTAGTCCCA GCTCCTTGGG AGACTGAGGC 40500 AGGAGAATGG CGTGAACCCG GGAGGCGGAG CTTGCAGTGA GCTGAGATTG CGCCACTGCA 40560 CTCCAGCCTG GGTGACACAG CAAGACTCCA TCTCAAAAAA AAAAGAAAAA AAATACTGTC 40620 ACCTGGGTCT GTCACTGGGA GAGGAGGTGA CACAGCTTCA CGCTTTGCAG TCTGTGCATG 40680 AACTGAGGGA CGGGTGTGTG GTGCGGGTCA CCGGTTGTGG CATGACTGAG GCGTGGACAG 40740 GTGTGCAGTG CGGGTCACTG GTTGTGGTGT GGACTGAGGC GTGTGCAGCC ATGTTTGCAT 40800 GTCACAAGTT ACAGTTCTTT CCATGTAACT TAATCATGTC CTTGAGGTCC TGCTGTTAAT 40860 TGGACAAATT GCAGTAACCG CAGCTCCTTG TGTATGGCAG AGCCGTGCAA AGCCGGGACT 40920 GCCTGTGTGG CTCCTTGAGT GCGCACAGGC CAAAGCTGAG ATGACTTGCC TGGGATGCCA 40980 CACGTGTTGG GCAGCAGACC GAGCCTCCCA CCCCTCCCTC TTGCCTCCCA GGTACCACGG 41040 CCCACGTGGG CATCATGCTG TATGGGGTGG ACAGCCGGAG CGGCCACCGG CACCTGGACG 41100 GCGACAGAGC CTTCCACCGC AACAGCCTGG ACATCTTCCG GATCGCCACC CCGCACAGCC 41160 TGGGTAGCGT GTGGAAGATC CGAGTGTGGC ACGACAACAA AGGTTTGTGC GGACCCTGCC 41220 AAGCTCTGCC CCTCTGCCCC CGCATTGGGG CGCCCTGCGA GCCTGACCTC CCTCCTGCGC 41280 CTCTGCAGGG CTCAGCCCTG CCTGGTTCCT GCAGCACGTC ATCGTCAGGG ACCTGCAGAC 41340 GGCACGCAGC GCCTTCTTCC TGGTCAATGA CTGGCTTTCG GTGGAGACGG AGGCCAACGG 41400 GGGCCTGGTG GAGAAGGAGG TGCTGGCCGC GAGTAAGGCC TCGTTCCATG GTCCCACTCC 41460 GTGGGAGGTT GGGCAGGGTG GTCCTGCCCC GTGGCCTCCT GCAGTGCGGC CCTCCCTGCC 41520 TTCTAGGCGA CGCAGCCCTT TTGCGCTTCC GGCGCCTGCT GGTGGCTGAG CTGCAGCGTG 41580 GCTTCTTTGA CAAGCACATC TGGCTCTCCA TATGGGACCG GCCGCCTCGT AGCCGTTTCA 41640 CTCGCATCCA GAGGGCCACC TGCTGCGTTC TCCTCATCTG CCTCTTCCTG GGCGCCAACG 41700 CCGTGTGGTA CGGGGCTGTT GGCGACTCTG CCTACAGGTG GGTGCCGTAG GGGTCGGGGC 41760 AGCCTCTTCC TGCCCAGCCC TTCCTGCCCC TCAGCCTCAC CTGTGTGGCC TCCTCTCCTC 41820 CACACAGCAC GGGGCATGTG TCCAGGCTGA GCCCGCTGAG CGTCGACACA GTCGCTGTTG 41880 GCCTGGTGTC CAGCGTGGTT GTCTATCCCG TCTACCTGGC CATCCTTTTT CTCTTCCGGA 41940 TGTCCCGGAG CAAGGTGGGC TGGGGCTGGG GACCCGGGAG TACTGGGAAT GGAGCCTGGG 42000 CCTCGGCACC ATGCCTAGGG CCGCCACTTT CCAGTGCTGC AGCCAGAGGG AAAGGCGTCC 42060 ACCAAAGGCT GCTCGGGAAG GGTCAACACA CTTGAGCAGC CTTAGCTAGA CTGACCAGGG 42120 AGAAAGAGAG AAGACTCAGA AGCCAGAATG GTGAAAGAAC GAGGGCACTT TGCTAAGCAG 42180 ACGCCACGGA CGACTGCACA GCAGCACGCC AGATAACTCA GAAGAAGCAA GCACGCGGCT 42240 GTGCACGCTT CCGAAATGCA CTCCAGAAGA AAATCTCAGT ACATCTATAG GAAGTGAAGA 42300 GGCTGAGTTA GTCCCTTAGA AACGTCCCAG TGGCCGGGCC GGGTGTGGTG GCTCACGCCT 42360 GTAATCCCAA CACTTCAGGT GGCCGAGGTG GGCGGATCTG AGTCCAGGAG TTTGAGACCA 42420 GCCTGGGCAA CATAGCAAGA CCCCATCTAT ATAAAACATT AAAAAGGGCC AGGCGCGGTG 42480 GCTCACGCCT GTAATCCCAG CACTTTGGGA GGCCGAGGCG GGCAGATCAC TTGAGGTCAG 42540 GAGTTCGAGA CCAGCCTGGC CAACACAATG AAACCCCGAC TCTACTACAA ATACAAAAAC 42600 TTAGCTGGGC ATGGTGGCGG GCGCCTGTAG TCCCAGCTAC TCGAGAGGCT GAGGCAGGAG 42660 AATGGCATGA ACCCAGGAGG CGGAGCTTGC AGTGAGCCGA GATTGCGCCA CTGCACTCCA 42720 TCCTGGGCAA CG G A G CAAGA CTCCATCTCC AAAAAAAAAA AAAAAAAATC CCACAAAGAA 42780 AAGCTCAGGC TCAGAGCCTT CACGATAGAA TTTTTCTAAG CAGTTAAGGA AGAATTAACA 42840 CCAATCCTTC ACAGACTCTT TCCAAGAATA CAGCAGGTGG GAACGCTTCC CATTCATACG 42900 GAAACGGGAG GCCGCACCCC TTAGGAATGC ACACGTGGGG TCCTCAAGAG GTTACATGCA 42960 AACTAACCCC AGCAGCACAC AGAGAAGGCG CATAAGCCGC GACCAGGAGG GGTTGCTCCC 43020 GAGTCCGTGG CAGGAACCAG AGGCCACATG TGGCTGCTCG TATTTAAGTT AATTAAAATG 43080 GAACGATGGC CGGGTGTGGT GGCTCACACC TGTAATCCCA GCACTTTGGG AGGCGGAGGC 43140 GGGCAGATCA CTTGAGGTCA GGAGTTCCAA GACCAGCCTG GCCAACACAG TGAAACCCCG 43200 TCTCTACTAA AAATACAAAA AATTAGCTGG GCATGGTGGC AGGCACCTGT AATCCCAGCT 43260 ACTCAGGAGG CTGAGCCAGG ACAATCGCCT GAACGCGGGA GGTGGAGGTT GCAGTGAGCT 43320 GAGATTGCGC CATTGCACTC CAGCCTGGGT GACAGCGAGA CTCCATCTAA AAAAGAAAAT 43380 ATGAAATTTA AAACTCTGTT CCTTAGCTGC ACCAGTCTGC TGTCAAGTGT TCAGTGGCAC 43440 ACGTCGCGAG GGGCTGCCAT CACGGACGGT GCAGATGTCC CATATATCCA GCATTCTAGG 43500 ACATTCTGTC AGATGGCACC GGGCTCTGTC CTGTCTGCTG AGGAGGTGGC TTCTCATCCC 43560 TGTCCTGAGC AGGTCTGAGC TGCCGCCCGC TGACCACTGC CCTCGTCCTG CAGGTGGCTG 43620 GGAGCCCGAG CCCCACACCT GCCGGGCAGC AGGTGCTGGA CATCGACAGC TGCCTGGACT 43680 CGTCCGTGCT GGACAGCTCC TTCCTCACGT TCTCAGGCCT CCACGCTGAG GTGAGGACTC 43740 TACTGGGGGT CCTGGGCTGG GCTGGGGGTC CTGCCGCCTT GGCGCAGCTT GGACTCAAGA 43800 CACTGTGCAC CTCTCAGCAG GCCTTTGTTG GACAGATGAA GAGTGACTTG TTTCTGGATG 43860 ATTCTAAGAG GTGGGTTCCC TAGAGAAACC TCGAGCCCTG GTGCAGGTCA CTGTGTCTGG 43920 GGTGCCGGGG GTGTGCGGGC TGCGTGTCCT TGCTGGGTGT CTGTGGCTCC ATGTGGTCAC 43980 ACCACCCGGG AGCAGGTTTG CTCGGAAGCC CAGGGTGTCC GTGCGTGACT GGACGGGGGT 44040 GGGCTGTGTG TGTGACACAT CCCCTGGTAC CTTGCTGACC CGCGCCACCT GCAGTCTGGT 44100 GTGCTGGCCC TCCGGCGAGG GAACGCTCAG TTGGCCGGAC CTGCTCAGTG ACCCGTCCAT 44160 TGTGGGTAGC AATCTGCGGC AGCTGGCACG GGGCCAGGCG GGCCATGGGC TGGGCCCAGA 44220 GGAGGACGGC TTCTCCCTGG CCAGCCCCTA CTCGCCTGCC AAATCCTTCT CAGCATCAGG 44280 TGAGCTGGGG TGAGAGGAGG GGGCTCTGAA GCTCACCCTT GCAGCTGGGC CCACCCTATG 44340 CCTCCTGTAC CTCTAGATGA AGACCTGATC CAGCAGGTCC TTGCCGAGGG GGTCAGCAGC 44400 CCAGCCCCTA CCCAAGACAC CCACATGGAA ACGGACCTGC TCAGCAGCCT GTGAGTGTCC 44460 GGCTCTCGGG GGAGGGGGGA TTGCCAGAGG AGGGGCCGGG ACTCAGGCCA GGCAGCCGTG 44520 GTTCCCGCCT GGGGTAGGGT GGGGTGGGGT GCCAGGGCAG GGCTGTGGCT GCACCACTTC 44580 ACTTCTCTGA ACCTCTGTTG TCTGTGGAAA GAGCCTCATG GGATCCCCAG GGCCCCAGAA 44640 CCTTCCCTCT AGGGAGGGAG CAGGCTCATG GGGCTTTGTA GGAGCAGAAA GGCTCCTGTG 44700 TGAGGCTGGC CGGGGCCACG TTTTTATCTT GGTCTCAGAG CAGTGAGAAA TTATGGGCGG 44760 GTTTTTAAAT ACCCCATTTT TGGCCGGGCG CGGTGGCTCA CACGTGTAAT CCCAGCACTT 44820 TGGGAGGCCG AGGTGGGCAG ATGACCTGAG GTCAGCAGTT CGAGACCAGC CTGGCCAACA 44880 TGGCGAAACC CCGTCTCTAC TAAAAATACA AAAAATTAGC CGGGCATGCT GGCAGGCGCC 44940 TGTAGTCCCA GTTACTCGGG AGACTGAGGT AGGAGAATCG ATTGAACCTG GTAGGTGAAG 45000 GTTGTAGTGA GCCGAGATCG CGCCACTGCA CTCCAGCCTG GGCAACAAGA GCGAAACTCC 45060 GTCTCAAAAA CAAAAAAATT CCTCAATTTC TTGGTTGTTT TGTAACTTAT CAACAAATGG 45120 TCATATAGAG GTTACCTTGT ATGTAGTCAC GCACATAGTC ACGCACATGG CAGCCGGCGG 45180 CGGAGCGCAC CCACGGCGTG TTCCCACGCG TGTGACCCCG GGCTCTGCCA TGCCCTCCTA 45240 TGCTCAGGTG TGCTGAGGTC CACACGGCCC TGCCGTTGCA CTGCAGCTGC CTGCAGGATT 45300 CAGTGCAGTG GCATGCAGTG CAGGTGCGGT GCCCCGGAGC CACAGGCCAC ACCACAGGGC 45360 CTGCATGCAC AGGGGCTGCG GTGTCTGGGT TTGGGTAACT ACGCCCTGTG ACATTTGCAC 45420 AGCAACAGAA TTACCTAATG ACGCATTTCT CAGAACACAT CCCTGGCACT AAGTGGTGCG 45480 TGACTGCTGC TTTTGCATCC ACATCTAGTT TGATTTGTGT GTTATTCCTT TGAGTGCTTC 45540 TCATTGTTAA GCAACCAAGA ACTAAAGAGG TATGAACTGC CCCTGGACTC AAACAAAAAG 45600 GAAAACTTCC TGATTTACAA AAGGCAGATA ACCATCACAT GAGGGCATCT TTATGAATAA 45660 ATTGCTGGTT GGTTTTAAAA ATACAGAGTA TGGGGAAATC CAGGGGTAGT CACTACATGC 45720 TGACCAGCCC CAGGTATCTC CGGCCCAAAG CTCTGTGAAA TCCAGATTCA GTGCTTCCGC 45780 GGGGATTTCT GACGGCAGCT CAGACTCCGC ATCCACACAG AGCGCGTGGC CCTCACCCTC 45840 CCGGCTTCCT CAACCCTTGG CCGTCCCTTG CTCGGACAGT GCTTCGGGCT GACCAGGTCG 45900 GAGGCTTGGG TTTGTCCTGG ACCCCTCTGC GTCCTTCCTC ACTGCAGCCT CCAGCGCGTC 45960 CCGTGGCTCC TTTCCCAACG CAGAGCACGG CCTTCCCTGC GCCTGAGCCT GCACCCTCCG 46020 TCCTGGCGGC GCCTCTGCCC TGGCATTCCC TGCCACTCCA TGCCTCCCTA TTGGCCATTC 46080 TCCGTCTCTG CCAGCGAGAG CCTCCTCCCT GAGTCAGACC CTGAGTCATT TGTGTTGCTA 46140 TAAAGGAATA GTTGAGGCTG GGTTATTTTT TATTTTTATT TATTTTTTTG AGATGGAGTC 46200 TCTGTTGCCC AGACTGGAGT GCAGTCGCAT GATCTCGGCT CACTGCAAAG TCTGCCTCCC 46260 ACGTTCAAGC AGTTATCTGC CTCAGCCTCC CAAGTAGCTA AGATTACAGG CGCCCGCCGC 46320 CACAGCCGGC TAATTTTTTG TGTGTGTGTT TTAGTAGAGA GGAGGTTTCA CCATCTTAGC 46380 CAGGCTGGTC TTGAACTCCT GACCTCGTGA TCCACCCATC TCAGCCTCCC AAAATGCTGΛ 46440 GAT T ACAGG C GT GA GCCACC ACGCCTGACC AAGTTGAGGC TAGGTCATTT TTTAATTTTT 46500 T G TAAAGACA GGGTCTCACT GTCTCCAACT CCTGAGCTCA AGTGATCCTC CTGCCTCAGC 46560 CTCCTGAAGT GCTGGGATTA CAGGCTTGAG ACACTGCGCC CAGCCAAGAG TGTCTTTTAT 46620 CCTCCGAGAG ACAGCAAAAC AGGAAGCATT CAGTGCAGTG TGACCCTGGG TCAGGCCGTT 46680 CTTTCGGTGA TGGGCTGACG AGGGCGCAGG TACGGGAGAG CGTCCTGAGA GCCCGGGACT 46740 CGGCGTCTCG CAGTTGGTCT CGTCCTCCCC CTCAACGTGT CTTCGCTGCC TCTGTACCTC 46800 TTCTCTAGCA GCTCTGGGAC CGGGCATATC AGCATGGTGG CCCGATGCAG TGGCACAGCC 46860 TCGGTGGTCA CTGGCTCCTG GAGACACAAG CAGATCTCTG GCCTCAGGGA GCCCTACACA 46920 CTGTTGGGAT TTGAAAGGCA TTCATATGTT TCCTTGTCCA GAAGTTAATT TTAGGCCATA 46980 AACCTGCATG GGACAGACAC ACTGGCGTCT CTAGATTGTA GAGATGCTTG TTGGATGGTT 47040 GAGACCCAAT CATAGTTTGC AGGGTTGAAG GGGGGCTCAT TGCACCCTGA GAGACTGTGC 47100 ACTGCTGTAA GGGCAGCTGG TCAGGCTGTG GGCGATGGGT TTATCAGCAG CAAGCGGGCG 47160 GGAGAGGGAC GCAGGCGGAC GCCTGACTTC GGTGCCTGGA GTGGCTCTTG GTTCCCTGGC 47220 TCCCAGCACC ACTCCCACTC TCGTTTGGGG TAGGGTCTTC CGGCTTTTTG TCGGGGGGAC 47280 CCTGTGACCC AAGAGGCTCA AGAAACTGCC CGCCCAGGTT AACATGGGCT TGGCTGCAAC 47340 TGCCTCCTGG AGGCCGGGAT GAATTCACAG CCTACCATGT CCCTCAGGTC CAGCACTCCT 47400 GGGGAGAAGA CAGAGACGCT GGCGCTGCAG AGGCTGGGGG AGCTGGGGCC ACCCAGCCCA 47460 GGCCTGAACT GGGAACAGCC CCAGGCAGCG AGGCTGTCCA GGACAGGTGT GCTTGCGTAG 47520 CCCCGGGATG CCCCTAGCCC CTCCCTGTGA GCTGCCTCTC ACAGGTCTGT CTCTGCTTCC 47580 CCAGGACTGG TGGAGGGTCT GCGGAAGCGC CTGCTGCCGG CCTGGTGTGC CTCCCTGGCC 47640 CACGGGCTCA GCCTGCTCCT GGTGGCTGTG GCTGTGGCTG TCTCAGGGTG GGTGGGTGCG 47700 AGCTTCCCCC CGGGCGTGAG TGTTGCGTGG CTCCTGTCCA GCAGCGCCAG CTTCCTGGCC 47760 TCATTCCTCG GCTGGGAGCC ACTGAAGGTG AGGGGGCTGC CAGGGGTAGG CTACAGGCCT 47820 CCATCACGGG GGACCCCTCT GAAGCCACCC CCTCCCCAGG TCTTGCTGGA AGCCCTGTAC 47880 TTCTCACTGG TGGCCAAGCG GCTGCACCCG GATGAAGATG ACACCCTGGT AGAGAGCCCG 47940 GCTGTGACGC CTGTGAGCGC ACGTGTGCCC CGCGTACGGC CACCCCACGG CTTTGCACTC 48000 TTCCTGGCCA AGGAAGAAGC CCGCAAGGTC AAGAGGCTAC ATGGCATGCT GCGGGTGAGC 48060 CTGGGTGCGG CCTGTGCCCC TGCCACCTCC GTCTCTTGTC TCCCACCTCC CACCCATGCA 48120 CGCAGGACAC TCCTGTCCCC CTTTCCTCAC CTCAGAAGGC CCTTAGGGGT TCAATGCTCT 48180 GCAGCCTTTG CCCGGTCTCC CTCCTACCCC ACGCCCCCCA CTTGCTGCCC CAGTCCCTGC 48240 CAGGGCCCAG CTCCAATGCC CACTCCTGCC TGGCCCTGAA GGCCCCTAAG CACCACTGCA 48300 GTGGCCTGTG TGTCTGCCCC CAGGTGGGGT TCCGGGCAGG GTGTGTGCTG CCATTACCCT 48360 GGCCAGGTAG AGTCTTGGGG CGCCCCCTGC CAGCTCACCT TCCTGCAGCC ACACCTGCCG 48420 CAGCCATGGC TCCAGCCGTT GCCAAAGCCC TGCTGTCACT GTGGGCTGGG GCCAGGCTGA 48480 CCACAGGGCC CCCCCGTCCA CCAGAGCCTC CTGGTGTACA TGCTTTTTCT GCTGGTGACC 48540 CTGCTGGCCA GCTATGGGGA TGCCTCATGC CATGGGCACG CCTACCGTCT GCAAAGCGCC 48600 ATCAAGCAGG AGCTGCACAG CCGGGCCTTC CTGGCCATCA CGCGGTACGG GCATCCGGTG 48660 CACTGGTCTG TCTTCTGGGC TTTAGTTTTG CCTTTAGTCC AGCCAGACCC TAGGGGACAT 48720 GTGGACATGT GTAGATACCT TTGTGGCTGC TAGAACTGGA GGTAGGTGCT GCTGGCATCA 48780 GTAGGCAGAG GGGAGGGACA CAGGTCCGTG TCTTGCAGTG CACAGGACGG GCCCATGACA 48840 GACAACTGTC TGCCCCAGAA CATCCCCAGG ATAAGGCTGA GAAGCCCAGG TCTAGCCGTG 48900 GCCAGCAGGG CAGTGGGAGC CATGTTCCCT GGGTCTCTGG TGGCCGCTCA CTCGAGGCGG 48960 GCATGGGGCA GTAGGGGCTG GAGCGTGTGA CTGATGCTGT GGCAGGTCTG AGGAGCTCTG 49020 GCCATGGATG GCCCACGTGC TGCTGCCCTA CGTCCACGGG AACCAGTCCA GCCCAGAGCT 49080 GGGGCCCCCA CGGCTGCGGC AGGTGCGGCT GCAGGAAGGT GAGCTGGCAG GGCGTGCCCC 49140 AAGACTTAAA TCGTTCCTCT TGTTGAGAGA GCAGCCTTTA GCGGAGCTCT GGCATCAGCC 49200 CTGCTCCCTA GCTGTGTGAC CTTTGCCCTC TTAACACCGC CGTTTCCTTC TCTGTATATG 49260 AGAGATGGTA ACGTTGTCTA ATTGATGGCT GCTGGGAGGG TTCCCTGGGG TGGCGCCGAA 49320 CCAGAGCTCA GGCGAGCTGG CCAGCAGGAA ACACTCCTGT TGGGTTTTGA TGAGGCCCTG 49380 GCCCCGGCCT GGGGCTCTGT GTGTTTCAGC ACTCTACCCA GACCCTCCCG GCCCCAGGGT 49440 CCACACGTGC TCGGCCGCAG GAGGCTTCAG CACCAGCGAT TACGACGTTG GCTGGGAGAG 49500 TCCTCACAAT GGCTCGGGGA CGTGGGCCTA TTCAGCGCCG GATCTGCTGG GGTGAGCAGA 49560 GCGAGGGCCC CGGGCGTCTA CGCCAAGGAC AAGGGAGTAG TTCTCCAGGA GTGCCGCGGC 49620 CTCCTGACCA GCCTGGCTCC GGGGTGCCGG AAGGGCTGGG GTGCGGCACC CACGCCACCC 49680 CTCTCCGGCA GGGCATGGTC CTGGGGCTCC TGTGCCGTGT ATGACAGCGG GGGCTACGTG 49740 CAGGAGCTGG GCCTGAGCCT GGAGGAGAGC CGCGACCGGC TGCGCTTCCT GCAGCTGCAC 49800 AACTGGCTGG ACAACAGGTG GGAGCTCCCT CCCCTGCCCT CTCCGGGGTG GCCGCAGTCA 49860 CCAGCCAGGA GCCCACCCTC ACTCCTCCGG CCCCCGCTGG CCTAGGCGGC TTCCACAGCC 49920 CCTCAGCCAC GCCTGCACTG CGCGGTCCCC GCAGCTCCCG CCCTGCCACC CGCTCCTACT 49980 GACCCGCACC CTCTGCGCAG GAGCCGCGCT GTGTTCCTGG AGCTCACGCG CTACAGCCCG 50040 GCCGTGGGGC TGCACGCCGC CGTCACGCTG CGCCTCGAGT TCCCGGCGGC CGGCCGCGCC 50100 CTGGCCGCCC TCAGCGTCCG CCCCTTTGCG CTGCGCCGCC TCAGCGCGGG CCTCTCGCTG 50160 CC T C TG C T C A CCTCGGTACG CCCGTCCCCG GCCAGACCCC GCGCCTCCCA CCGGCAGCGT 50220 CCCGCCCCCT CGCGGGGCCC CGCCCGGCAG CGTCTCACCC CTCGCAGCGC CCCGCCCCCT 50280 CGCAGCGTCC CGCCCCCTCG CAGGGCCCCG CCCCGGCAGC GTCCCGCCCC CTCGTAGGGC 50340 CCCGCCCCGG CAGCGTCCCG CCCCCTCGCA GGGCCCCGCC CCGGCAGCGT CCCTCCCGCC 50400 CTCCTGACCG CGCCCCCCAC AGGTGTGCCT GCTCCTCTTC GCCGTGCACT TCGCCGTGGC 50460 CGAGGCCCGT ACTTGGCACA GGGAAGGGCG CTGGCGCGTG CTGCGGCTCG GAGCCTGGGC 50520 GCGGTGGCTG CTGGTGGCGC TGACGGCGGC CACGGCACTG GTACGCCTCG CCCAGCTGGG 50580 TGCCGCTGAC CGCCAGTGGA CCCGTTTCGT GCGCGGCCGC CCGCGCCGCT TCACTAGCTT 50640 CGACCAGGTG GCGCAGCTGA GCTCCGCAGC CCGTGGCCTG GCGGCCTCGC TGCTCTTCCT 50700 GCTTTTGGTC AAGGTGAGGG CTGGGCCGGT GGGCGCGGGG CTGGGCGCAC ACCCCAGGGC 50760 TGCAAGCAGA CAGATTTCTC GTCCGCAGGC TGCCCAGCAG CTACGCTTCG TGCGCCAGTG 50820 GTCCGTCTTT GGCAAGACAT TATGCCGAGC TCTCCCAGAG CTCCTGGGGG TCACCTTGGG 50880 CCTGGTGGTG CTCGGGGTAG CCTACGCCCA GCTGGCCATC CTGGTAGGTG ACTGCGCGGC 50940 CGGGGAGGGC GTCTTAGCTC AGCTCAGCTC AGCTGTACGC CCTCACTGGT GTCGCCTTCC 51000 CCGCAGCTCG TGTCTTCCTG TGTGGACTCC CTCTGGAGCG TGGCCCAGGC CCTGTTGGTG 51060 CTGTGCCCTG GGACTGGGCT CTCTACCCTG TGTCCTGCCG AGTCCTGGCA CCTGTCACCC 51120 CTGCTGTGTC TGGGGCTCTG GGCACTGCGG CTGTGGGGCG CCCTACGGCT GGGGGCTGTT 51180 ATTCTCCGCT GGCGCTACCA CGCCTTGCGT GGAGAGCTGT ACCGGCCGGC CTGGGAGCCC 51240 CAGGACTACG AGATGGTGGA GTTGTTCCTG CGCAGGCTGC GCCTCTGGAT GGGCCTCAGC 51300 AAGGTCAAGG AGGTGGGTAC GGCCCAGTGG GGGGGAGAGG GACACGCCCT GGGCTCTGCC 51360 CAGGGTGCAG CCGGACTGAC TGAGCCCCTG TGCCGCCCCC AGTTCCGCCA CAAAGTCCGC 51420 TTTGAAGGGA TGGAGCCGCT GCCCTCTCGC TCCTCCAGGG GCTCCAAGGT ATCCCCGGAT 51480 GTGCCCCCAC CCAGCGCTGG CTCCGATGCC TCGCACCCCT CCACCTCCTC CAGCCAGCTG 51540 GATGGGCTGA GCGTGAGCCT GGGCCGGCTG GGGACAAGGT GTGAGCCTGA GCCCTCCCGC 51600 CTCCAAGCCG TGTTCGAGGC CCTGCTCACC CAGTTTGACC GACTCAACCA GGCCACAGAG 51660 GACGTCTACC AGCTGGAGCA GCAGCTGCAC AGCCTGCAAG GCCGCAGGAG CAGCCGGGCG 51720 CCCGCCGGAT CTTCCCGTGG CCCATCCCCG GGCCTGCGGC CAGCACTGCC CAGCCGCCTT 51780 GCCCGGGCCA GTCGGGGTGT GGACCTGGCC ACTGGCCCCA GCAGGACACC CCTTCGGGCC 51840 AAGAACAAGG TCCACCCCAG CAGCACTTAG TCCTCCTTCC TGGCGGGGGT GGGCCGTGGA 51900 GTCGGAGTGG ACACCGCTCA GTATTACTTT CTGCCGCTGT CAAGGCCGAG GGCCAGGCAG 51960 AATGGCTGCA CGTAGGTTCC CCAGAGAGCA GGCAGGGGCA TCTGTCTGTC TGTGGGCTTC 52020 AGCACTTTAA AGAGGCTGTG TGGCCAACCA GGACCCAGGG TCCCCTCCCC AGCTCCCTTG 52080 GGAAGGACAC AGCAGTATTG GACGGTTTCT AGCCTCTGAG ATGCTAATTT ATTTCCCCGA 52140 GTCCTCAGGT ACAGCGGGCT GTGCCCGGCC CCACCCCCTG GGCAGATGTC CCCCACTGCT 52200 AAGGCTGCTG GCTTCAGGGA GGGTTAGCCT GCACCGCCGC CACCCTGCCC CTAAGTTATT 52260 ACCTCTCCAG TTCCTACCGT ACTCCCTGCA CCGTCTCACT GTGTGTCTCG TGTCAGTAAT 52320 TTATATGGTG TTAAAATGTG TATATTTTTG TATGTCACTA TTTTCACTAG GGCTGAGGGG 52380 CCTGCGCCCA GAGCTGGCCT CCCCCAACAC CTGCTGCGCT TGGTAGGTGT GGTGGCGTTA 52440 TGGCAGCCCG GCTGCTGCTT GGATGCGAGC TTGGCCTTGG GCCGGTGCTG GGGGCACAGC 52500 TGTCTGCCAG GCACTCTCAT CACCCCAGAG GCCTTGTCAT CCTCCCTTGC CCCAGGCCAG 52560 GTAGCAAGAG AGCAGCGCCC AGGCCTGCTG GCATCAGGTC TGGGCAAGTA GCAGGACTAG 52620 GCATGTCAGA GGACCCCAGG GTGGTTAGAG GAAAAGACTC CTCCTGGGGG CTGGCTCCCA 52680 GGGTGGAGGA AGGTGACTGT GTGTGTGTGT GTGTGCGCGC GCGCACGCGC GAGTGTGCTG 52740 TATGGCCCAG GCAGCCTCAA GGCCCTCGGA GCTGGCTGTG CCTGCTTCTG TGTACCACTT 52800 CTGTGGGCAT GGCCGCTTCT AGAGCCTCGA CACCCCCCCA ACCCCCGCAC CAAGCAGACA 52860 AAGTCAATAA AAGAGCTGTC TGACTGCAAT CTGTGCCTCT ATGTCTGTGC ACTGGGGTCA 52920 GGACTTTATT TATTTCACTG ACAGGCAATA CCGTCCAAGG CCAGTGCAGG AGGGAGGGCC 52980 CCGGCCTCAC ACAAACTCGG TGAAGTCCTC CACCGAGGAG ATGAGGCGCT TCCGCTGGCC 53040 CACCTCATAG CCAGGTGTGG GCTCGGCTGG AGTCTGTGCA GGGGCTTTGC TATGGGACGG 53100 AGGGTGCACC AGAGGTAGGC TGGGGTTGGA GTAGGCGGCT TCCTCGCAGA TCTGAAGGCA 53160 GAGGCGGCTT GGGCAGTAAG TCTGGGAGGC GTGGCAACCG CTCTGCCCAC ACACCCGCCC 53220 CACAGCTTGG GCAGCCAGCA CACCCCGCTG AGGGAGCCCC ATATTCCCTA CCCGCTGGCG 53280 GAGCGCTTGA TGTGGCGGAG CGGGCAATCC ACTTGGAGGG GTAGATATCG GTGGGGTTGG 53340 AGCGGCTATG ATGCACCTGT GAGGCCATCT GGGGACGTAG GCAGGGGGTG AGCTCACTAT 53400 CAGGTGGCAC CTGGGCCTGT CCCACCAGCT CACGCCTGGA CCCACCCCCA CTCACATTTG 53460 CGTGCAGGGC CATCTGGCGG GCCACGAAGG GCAGGTTGCG GTCAGACACG ATCTTGGCCA 53520 CGCTGG 53526 ( 2 ) INFORMATION FOR SEQ ID NO : 3 : ( i ) SEQUENCE CHARACTERISTICS : (A) LENGTH : 894 base pairs ( B ) TYPE : nucleic acid (C ) STRANDEDNESS : single (D) TOPOLOGY : linear ( i i ) MOLECULE TYPE : DNA ( genomic ) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3: GGTGTGAGGG GTAGGGGCAG GGTGGGAGGT GGGCTCGCGG GTGGGCTGGG GTCATGAAGG 60 GCCTCAGGCG CTCTGCTATT GGGTTCCAAG GCTATCCTGA GAACAGGGGT GAGGGGGGAT 120 TGCCGTGGGG GGTTAAAGCC TTGTCATGTT CGCTTTCGGG AGATAAAAAC AACAGGTGGC 180 CTTTATGGAG ACGCTGCCCA GAGCCAGGTC TGTGCCAGGC TCCTGTTGGG GGTCGTCATG 240 CGGAATCCTG ACTCTGACCA TCCGAGGCAT AGGGACCGTG GAGATTTGCA TTTCACAGAT 300 GAGGAAACAG GTTTGGAGAG GTGACACGAC CTGTCCCAGG CATCACAGCC GGGATGTGCA 360 TAGCAGGGGT TTGGAACTAT GAGGTGCCCA GGACCCAGGG TTGGATTGAA AAGGGCGGAG 420 GGGACTAAGA TAAGCAGACA GTTGTCCCCA GCGCTGGGGA GAGTCTTGGG ACCAGTCTGA 480 TGCCTTGTAT TTCCCAGGCT CCAGGCTCCT CGCCGGGACA GTGTCTCCTT GGGTGCGTGC 540 TGGATCCCTG GGGGACGTGG CACATCCCCA GGCTTGCTAA ACATTGGGTG GGTTCTGGCA 600 TTTGGTTTTG TAACGTTTCT GGGTCACTCC CGCCTGTGGC CACCCTTCCT TAGGGGAGCC 660 GTGTGTCCTT GGGGCTTTGC TGGGTGGTCT CGAGGGTGGG AGAAGAATGG GTTCTCCTGG 720 ACCAATGGAG CCCGTGCCCC TCGGGGCCAC ATTGCTCCTG CGCTCCCTGA CTGCGGACGC 780 GTGTGTCTCG CGGCTGTCTC TGTGGAGATG GCCTCCTCCT GCCTGGCAAC AGCACCCACA 840 GAATTGCATC AGACCTACCC CACCCGTTGT TTGTGATCCT GTAGCTGAGG GCTC 894 (2) INFORMATION FOR SEQ ID NO:4: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14060 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 135..13040 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4: GCTCAGCAGC AGGTCGCGGC CGCAGCCCCA TCCAGCCCGC GCCCGCCATG CCGTCCGCGG 60 GCCCCGCCTG AGCTGCGGCC TCCGCGCGCG GGCGGGCCTG GGGACGGCGG GGCCATGCGC 120 GCGCTGCCCT AACG ATG CCG CCC GCC GCG CCC GCC CGC CTG GCG CTG GCC 170 Met Pro Pro Ala Ala Pro Ala Arg Leu Ala Leu Ala 1 5 10 CTG GGC CTG GGC CTG TGG CTC GGG GCG CTG GCG GGG GGC CCC GGG CGC 218 Leu Gly Leu Gly Leu Trp Leu Gly Ala Leu Ala Gly Gly Pro Gly Arg 15 20 25 GGC TGC GGG CCC TGC GAG CCC CCC TGC CTC TGC GGC CCA GCG CCC GGC 266 Gly Cys Gly Pro Cys Glu Pro Pro Cys Leu Cys Gly Pro Ala Pro Gly 30 35 40 GCC GCC TGC CGC GTC AAC TGC TCG GGC CGC GGG CTG CGG ACG CTC GGT 314 Ala Ala Cys Arg Val Asn Cys Ser Gly Arg Gly Leu Arg Thr Leu Gly 45 50 55 60 CCC GCG CTG CGC ATC CCC GCG GAC GCC ACA GCG CTA GAC GTC TCC CAC 362 Pro Ala Leu Arg lie Pro Ala Asp Ala Thr Ala Leu Asp Val Ser His 65 70 75 AAC CTG CTC CGG GCG CTG GAC GTT GGG CTC CTG GCG AAC CTC TCG GCG 410 Asn Leu Leu Arg Ala Leu Asp Val Gly Leu Leu Ala Asn Leu Ser Ala 80 85 90 CTG GCA GAG CTG GAT ATA AGC AAC AAC AAG ATT TCT ACG TTA GAA GAA 458 Leu Ala Glu Leu Asp lie Ser Asn Asn Lys lie Ser Thr Leu Glu Glu 95 100 105 GGA ATA TTT GCT AAT TTA TTT AAT TTA AGT GAA ATA AAC CTG AGT GGG 506 Gly lie Phe Ala Asn Leu Phe Asn Leu Ser Glu lie Asn Leu Ser Gly 110 115 120 AAC CCG TTT GAG TGT GAC TGT GGC CTG GCG TGG CTG CCG CGA TGG GCG 554 Asn Pro Phe Glu Cys Asp Cys Gly Leu Ala Trp Leu Pro Arg Trp Ala 125 130 135 140 GAG GAG CAG CAG GTG CGG GTG GTG CAG CCC GAG GCA GCC ACG TGT GCT 602 Glu Glu Gin Gin Val Arg Val Val Gin Pro Glu Ala Ala Thr Cys Ala 145 150 155 GGG CCT GGC TCC CTG GCT GGC CAG CCT CTG CTT GGC ATC CCC TTG CTG 650 Gly Pro Gly Ser Leu Ala Gly Gin Pro Leu Leu Gly lie Pro Leu Leu 160 165 170 GAC AGT GGC TGT GGT GAG GAG TAT GTC GCC TGC CTC CCT GAC AAC AGC 698 Asp Ser Gly Cys Gly Glu Glu Tyr Val Ala Cys Leu Pro Asp Asn Ser 175 180 185 TCA GGC ACC GTG GCA GCA GTG TCC TTT TCA GCT GCC CAC GAA GGC CTG 746 Ser Gly Thr Val Ala Ala Val Ser Phe Ser Ala Ala His Glu Gly Leu 190 195 200 CTT CAG CCA GAG GCC TGC AGC GCC TTC TGC TTC TCC ACC GGC CAG GGC 794 Leu Gin Pro Glu Ala Cys Ser Ala Phe Cys Phe Ser Thr Gly Gin Gly 205 210 215 220 CTC GCA GCC CTC TCG GAG CAG GGC TGG TGC CTG TGT GGG GCG GCC CAG 842 Leu Ala Ala Leu Ser Glu Gin Gly Trp Cys Leu Cys Gly Ala Ala Gin 225 230 235 CCC TCC AGT GCC TCC TTT GCC TGC CTG TCC CTC TGC TCC GGC CCC CCG 890 Pro Ser Ser Ala Ser Phe Ala Cys Leu Ser Leu Cys Ser Gly Pro Pro 240 245 250 CCA CCT CCT GCC CCC ACC TGT AGG GGC CCC ACC CTC CTC CAG CAC GTC 938 Pro Pro Pro Ala Pro Thr Cys Arg Gly Pro Thr Leu Leu Gin His Val 255 260 265 TTC CCT GCC TCC CCA GGG GCC ACC CTG GTG GGG CCC CAC GGA CCT CTG 986 Phe Pro Ala Ser Pro Gly Ala Thr Leu Val Gly Pro His Gly Pro Leu 270 275 280 GCC TCT GGC CAG CTA GCA GCC TTC CAC ATC GCT GCC CCG CTC CCT GTC 1034 Ala Ser Gly Gin Leu Ala Ala Phe His lie Ala Ala Pro Leu Pro Val 285 290 295 300 ACT GCC ACA CGC TGG GAC TTC GGA GAC GGC TCC GCC GAG GTG GAT GCC 1082 Thr Ala Thr Arg Trp Asp Phe Gly Asp Gly Ser Ala Glu Val Asp Ala 305 310 315 GCT GGG CCG GCT GCC TCG CAT CGC TAT GTG CTG CCT GGG CGC TAT CAC 1130 Ala Gly Pro Ala Ala Ser His Arg Tyr Val Leu Pro Gly Arg Tyr His 320 325 330 GTG ACG GCC GTG CTG GCC CTG GGG GCC GGC TCA GCC CTG CTG GGG ACA 1178 Val Thr Ala Val Leu Ala Leu Gly Ala Gly Ser Ala Leu Leu Gly Thr 335 340 345 GAC GTG CAG GTG GAA GCG GCA CCT GCC GCC CTG GAG CTC GTG TGC CCG 1226 Asp Val Gin Val Glu Ala Ala Pro Ala Ala Leu Glu Leu Val Cys Pro 350 355 360 TCC TCG GTG CAG AGT GAC GAG AGC CTC GAC CTC AGC ATC CAG AAC CGC 1274 Ser Ser Val Gin Ser Asp Glu Ser Leu Asp Leu Ser lie Gin Asn Arg 365 370 375 380 GGT GGT TCA GGC CTG GAG GCC GCC TAC AGC ATC GTG GCC CTG GGC GAG 1322 Gly Gly Ser Gly Leu Glu Ala Ala Tyr Ser lie Val Ala Leu Gly Glu 385 390 ' 395 GAG CCG GCC CGA GCG GTG CAC CCG CTC TGC CCC TCG GAC ACG GAG ATC 1370 Glu Pro Ala Arg Ala Val His Pro Leu Cys Pro Ser Asp Thr Glu lie 400 405 410 TTC CCT GGC AAC GGG CAC TGC TAC CGC CTG GTG GTG GAG AAG GCG GCC 1418 Phe Pro Gly Asn Gly His Cys Tyr Arg Leu Val Val Glu Lys Ala Ala 415 420 425 TGG CTG CAG GCG CAG GAG CAG TGT CAG GCC TGG GCC GGG GCC GCC CTG 1466 Trp Leu Gin Ala Gin Glu Gin Cys Gin Ala Trp Ala Gly Ala Ala Leu 430 435 440 GCA ATG GTG GAC AGT CCC GCC GTG CAG CGC TTC CTG GTC TCC CGG GTC 1514 Ala Met Val Asp Ser Pro Ala Val Gin Arg Phe Leu Val Ser Arg Val 445 450 455 460 ACC AGG TGC CTA GAC GTG TGG ATC GGC TTC TCG ACT GTG CAG GGG GTG 1562 Thr Arg Cys Leu Asp Val Trp lie Gly Phe Ser Thr Val Gin Gly Val 465 470 475 GAG GTG GGC CCA GCG CCG CAG GGC GAG GCC TTC AGC CTG GAG AGC TGC 1610 Glu Val Gly Pro Ala Pro Gin Gly Glu Ala Phe Ser Leu Glu Ser Cys 480 485 490 CAG AAC TGG CTG CCC GGG GAG CCA CAC CCA GCC ACA GCC GAG CAC TGC 1658 Gin Asn Trp Leu Pro Gly Glu Pro His Pro Ala Thr Ala Glu His Cys 495 500 505 GTC CGG CTC GGG CCC ACC GGG TGG TGT AAC ACC GAC CTG TGC TCA GCG 1706 Val Arg Leu Gly Pro Thr Gly Trp Cys Asn Thr Asp Leu Cys Ser Ala 510 515 520 CCG CAC AGC TAC GTC TGC GAG CTG CAG CCC GGA GGC CCA GTG CAG GAT 1754 Pro His Ser Tyr Val Cys Glu Leu Gin Pro Gly Gly Pro Val Gin Asp 525 530 535 540 GCC GAG AAC CTC CTC GTG GGA GCG CCC AGT GGG GAC CTG CAG GGA CCC 1802 Ala Glu Asn Leu Leu Val Gly Ala Pro Ser Gly Asp Leu Gin Gly Pro 545 550 555 CTG ACG CCT CTG GCA CAG CAG GAC GGC CTC TCA GCC CCG CAC GAG CCC 1850 Leu Thr Pro Leu Ala Gin Gin Asp Gly Leu Ser Ala Pro His Glu Pro 560 565 570 GTG GAG GTC ATG GTA TTC CCG GGC CTG CGT CTG AGC CGT GAA GCC TTC 1898 Val Glu Val Met Val Phe Pro Gly Leu Arg Leu Ser Arg Glu Ala Phe 575 580 585 CTC ACC ACG GCC GAA TTT GGG ACC CAG GAG CTC CGG CGG CCC GCC CAG 1946 Leu Thr Thr Ala Glu Phe Gly Thr Gin Glu Leu Arg Arg Pro Ala Gin 590 595 600 CTG CGG CTG CAG GTG TAC CGG CTC CTC AGC ACA GCA GGG ACC CCG GAG 1994 Leu Arg Leu Gin Val Tyr Arg Leu Leu Ser Thr Ala Gly Thr Pro Glu 605 610 615 620 AAC GGC AGC GAG CCT GAG AGC AGG TCC CCG GAC AAC AGG ACC CAG CTG 2042 Asn Gly Ser Glu Pro Glu Ser Arg Ser Pro Asp Asn Arg Thr Gin Leu 625 630 635 GCC CCC GCG TGC ATG CCA GGG GGA CGC TGG TGC CCT GGA GCC AAC ATC 2090 Ala Pro Ala Cys Met Pro Gly Gly Arg Trp Cys Pro Gly Ala Asn lie 640 645 650 TGC TTG CCG CTG GAC GCC TCC TGC CAC CCC CAG GCC TGC GCC AAT GGC 2138 Cys Leu Pro Leu Asp Ala Ser Cys His Pro Gin Ala Cys Ala Asn Gly 655 660 665 TGC ACG TCA GGG CCA GGG CTA CCC GGG GCC CCC TAT GCG CTA TGG AGA 2186 Cys Thr Ser Gly Pro Gly Leu Pro Gly Ala Pro Tyr Ala Leu Trp Arg 670 675 680 GAG TTC CTC TTC TCC GTT CCC GCG GGG CCC CCC GCG CAG TAC TCG GTC 2234 Glu Phe Leu Phe Ser Val Pro Ala Gly Pro Pro Ala Gin Tyr Ser Val 685 690 695 700 ACC CTC CAC GGC CAG GAT GTC CTC ATG CTC CCT GGT GAC CTC GTT GGC 2282 Thr Leu His Gly Gin Asp Val Leu Met Leu Pro Gly Asp Leu Val Gly 705 710 715 TTG CAG CAC GAC GCT GGC CCT GGC GCC CTC CTG CAC TGC TCG CCG GCT 2330 Leu Gin His Asp Ala Gly Pro Gly Ala Leu Leu His Cys Ser Pro Ala 720 725 730 CCC G GC CAC CCT GGT CCC CGG GCC CCG TAC CTC TCC GCC AAC GCC TCG 2378 Pro Gly His Pro Gly Pro Arg Ala Pro Tyr Leu Ser Ala Asn Ala Ser 735 740 745 TCA TGG CTG CCC CAC TTG CCA GCC CAG CTG GAG GGC ACT TGG GCC TGC 2426 Ser Trp Leu Pro His Leu Pro Ala Gin Leu Glu Gly Thr Trp Ala Cys 750 755 760 CCT GCC TGT GCC CTG CGG CTG CTT GCA GCC ACG GAA CAG CTC ACC GTG 2474 Pro Ala Cys Ala Leu Arg Leu Leu Ala Ala Thr Glu Gin Leu Thr Val 765 770 775 780 CTG CTG GGC TTG AGG CCC AAC CCT GGA CTG CGG CTG CCT GGG CGC TAT 2522 Leu Leu Gly Leu Arg Pro Asn Pro Gly Leu Arg Leu Pro Gly Arg Tyr 785 790 795 GAG GTC CGG GCA GAG GTG GGC AAT GGC GTG TCC AGG CAC AAC CTC TCC 2570 Glu Val Arg Ala Glu Val Gly Asn Gly Val Ser Arg His Asn Leu Ser 800 805 810 TGC AGC TTT GAC GTG GTC TCC CCA GTG GCT GGG CTG CGG GTC ATC TAC 2618 Cys Ser Phe Asp Val Val Ser Pro Val Ala Gly Leu Arg Val lie Tyr 815 820 825 CCT GCC CCC CGC GAC GGC CGC CTC TAC GTG CCC ACC AAC GGC TCA GCC 2666 Pro Ala Pro Arg Asp Gly Arg Leu Tyr Val Pro Thr Asn Gly Ser Ala 830 835 840 TTG GTG CTC CAG GTG GAC TCT GGT GCC AAC GCC ACG GCC ACG GCT CGC 2714 Leu Val Leu Gin Val Asp Ser Gly Ala Asn Ala Thr Ala Thr Ala Arg 845 850 855 860 TGG CCT GGG GGC AGT GTC AGC GCC CGC TTT GAG AAT GTC TGC CCT GCC 2762 Trp Pro Gly Gly Ser Val Ser Ala Arg Phe Glu Asn Val Cys Pro Ala 865 870 875 CTG GTG GCC ACC TTC GTG CCC GGC TGC CCC TGG GAG ACC AAC GAT ACC 2810 Leu Val Ala Thr Phe Val Pro Gly Cys Pro Trp Glu Thr Asn Asp Thr 880 885 890 CTG TTC TCA GTG GTA GCA CTG CCG TGG CTC AGT GAG GGG GAG CAC GTG 2858 Leu Phe Ser Val Val Ala Leu Pro Trp Leu Ser Glu Gly Glu His Val 895 900 905 GTG GAC GTG GTG GTG GAA AAC AGC GCC AGC CGG GCC AAC CTC AGC CTG 2906 Val Asp Val Val Val Glu Asn Ser Ala Ser Arg Ala Asn Leu Ser Leu 910 915 920 CGG GTG ACG GCG GAG GAG CCC ATC TGT GGC CTC CGC GCC ACG CCC AGC 2954 Arg Val Thr Ala Glu Glu Pro lie Cys Gly Leu Arg Ala Thr Pro Ser 925 930 935 940 CCC GAG GCC CGT GTA CTG CAG GGA GTC CTA GTG AGG TAC AGC CCC GTG 3002 Pro Glu Ala Arg Val Leu Gin Gly Val Leu Val Arg Tyr Ser Pro Val 945 950 955 GTG GAG GCC GGC TCG GAC ATG GTC TTC CGG TGG ACC ATC AAC GAC AAG 3050 Val Glu Ala Gly Ser Asp Met Val Phe Arg Trp Thr lie Asn Asp Lys 960 965 970 CAG TCC CTG ACC TTC CAG AAC GTG GTC TTC AAT GTC ATT TAT CAG AGC 3098 Gin Ser Leu Thr Phe Gin Asn Val Val Phe Asn Val lie Tyr Gin Ser 975 980 985 GCG GCG GTC TTC AAG CTC TCA CTG ACG GCC TCC AAC CAC GTG AGC AAC 3146 Ala Ala Val Phe Lys Leu Ser Leu Thr Ala Ser Asn His Val Ser Asn 990 995 1000 GTC ACC GTG AAC TAC AAC GTA ACC GTG GAG CGG ATG AAC AGG ATG CAG 3194 Val Thr Val Asn Tyr Asn Val Thr Val Glu Arg Met Asn Arg Met Gin 1005 1010 1015 1020 GGT CTG CAG GTC TCC ACA GTG CCG GCC GTC CTG TCC CCC AAT GCC ACG 3242 Gly Leu Gin Val Ser Thr Val Pro Ala Val Leu Ser Pro Asn Ala Thr 1025 1030 1035 CTA GCA CTG ACG GCG GGC GTG CTG GTG GAC TCG GCC GTG GAG GTG GCC 3290 Leu Ala Leu Thr Ala Gly Val Leu Val Asp Ser Ala Val Glu Val Ala 1040 1045 1050 TTC CTG TGG ACC TTT GGG GAT GGG GAG CAG GCC CTC CAC CAG TTC CAG 3338 Phe Leu Trp Thr Phe Gly Asp Gly Glu Gin Ala Leu His Gin Phe Gin 1055 1060 1065 CCT CCG TAC AAC GAG TCC TTC CCG GTT CCA GAC CCC TCG GTG GCC CAG 3386 Pro Pro Tyr Asn Glu Ser Phe Pro Val Pro Asp Pro Ser Val Ala Gin 1070 1075 1080 GTG CTG GTG GAG CAC AAT GTC ATG CAC ACC TAC GCT GCC CCA GGT GAG 3434 Val Leu Val Glu His Asn Val Met His Thr Tyr Ala Ala Pro Gly Glu 1085 1090 1095 1100 TAC CTC CTG ACC GTG CTG GCA TCT AAT GCC TTC GAG AAC CTG ACG CAG 3482 Tyr Leu Leu Thr Val Leu Ala Ser Asn Ala Phe Glu Asn Leu Thr Gin 1105 1110 1115 CAG GTG CCT GTG AGC GTG CGC GCC TCC CTG CCC TCC GTG GCT GTG GGT 3530 Gin Val Pro Val Ser Val Arg Ala Ser Leu Pro Ser Val Ala Val Gly 1120 1125 1130 GTG AGT GAC GGC GTC CTG GTG GCC GGC CGG CCC GTC ACC TTC TAC CCG 3578 Val Ser Asp Gly Val Leu Val Ala Gly Arg Pro Val Thr Phe Tyr Pro 1135 1140 1145 CAC CCG CTG CCC TCG CCT GGG GGT GTT CTT TAC ACG TGG GAC TTC GGG 3626 His Pro Leu Pro Ser Pro Gly Gly Val Leu Tyr Thr Trp Asp Phe Gly 1150 1155 1160 GAC GGC TCC CCT GTC CTG ACC CAG AGC CAG CCG GCT GCC AAC CAC ACC 3674 Asp Gly Ser Pro Val Leu Thr Gin Ser Gin Pro Ala Ala Asn His Thr 1165 1170 1175 1180 TAT GCC TCG AGG GGC ACC TAC CAC GTG CGC CTG GAG GTC AAC AAC ACG 3722 Tyr Ala Ser Arg Gly Thr Tyr His Val Arg Leu Glu Val Asn Asn Thr 1185 1190 1195 GTG AGC GGT GCG GCG GCC CAG GCG GAT GTG CGC GTC TTT GAG GAG CTC 3770 Val Ser Gly Ala Ala Ala Gin Ala Asp Val Arg Val Phe Glu Glu Leu 1200 1205 1210 CGC GGA CTC AGC GTG GAC ATG AGC CTG GCC GTG GAG CAG GGC GCC CCC 3818 Arg Gly Leu Ser Val Asp Met Ser Leu Ala Val Glu Gin Gly Ala Pro 1215 1220 1225 GTG GTG GTC AGC GCC GCG GTG CAG ACG GGC GAC AAC ATC ACG TGG ACC 3866 Val Val Val Ser Ala Ala Val Gin Thr Gly Asp Asn lie Thr Trp Thr 1230 1235 1240 TTC GAC ATG GGG GAC GGC ACC GTG CTG TCG GGC CCG GAG GCA ACA GTG 3914 Phe Asp Met Gly Asp Gly Thr Val Leu Ser Gly Pro Glu Ala Thr Val 1245 1250 1255 1260 GAG CAT GTG TAC CTG CGG GCA CAG AAC TGC ACA GTG ACC GTG GGT GCG 3962 Glu His Val Tyr Leu Arg Ala Gin Asn Cys Thr Val Thr Val Gly Ala 1265 1270 1275 GCC AGC CCC GCC GGC CAC CTG GCC CGG AGC CTG CAC GTG CTG GTC TTC 4010 Ala Ser Pro Ala Gly His Leu Ala Arg Ser Leu His Val Leu Val Phe 1280 1285 1290 GTC CTG GAG GTG CTG CGC GTT GAA CCC GCC GCC TGC ATC CCC ACG CAG 4058 Val Leu Glu Val Leu Arg Val Glu Pro Ala Ala Cys lie Pro Thr Gin 1295 1300 1305 CCT GAC GCG CGG CTC ACG GCC TAC GTC ACC GGG AAC CCG GCC CAC TAC 4106 Pro Asp Ala Arg Leu Thr Ala Tyr Val Thr Gly Asn Pro Ala His Tyr 1310 1315 1320 CTC TTC GAC TGG ACC TTC GGG GAT GGC TCC TCC AAC ACG ACC GTG CGG 4154 Leu Phe Asp Trp Thr Phe Gly Asp Gly Ser Ser Asn Thr Thr Val Arg 1325 1330 1335 1340 GGG TGC CCG ACG GTG ACA CAC AAC TTC ACG CGG AGC GGC ACG TTC CCC 4202 Gly Cys Pro Thr Val Thr His Asn Phe Thr Arg Ser Gly Thr Phe Pro 1345 1350 1355 CTG GCG CTG GTG CTG TCC AGC CGC GTG AAC AGG GCG CAT TAC TTC ACC 4250 Leu Ala Leu Val Leu Ser Ser Arg Val Asn Arg Ala His Tyr Phe Thr 1360 1365 1370 AGC ATC TGC GTG GAG CCA GAG GTG GGC AAC GTC ACC CTG CAG CCA GAG 4298 Ser lie Cys Val Glu Pro Glu Val Gly Asn Val Thr Leu Gin Pro Glu 1375 1380 1385 AGG CAG TTT GTG CAG CTC GGG GAC GAG GCC TGG CTG GTG GCA TGT GCC 4346 Arg Gin Phe Val Gin Leu Gly Asp Glu Ala Trp Leu Val Ala Cys Ala 1390 1395 1400 TGG CCC CCG TTC CCC TAC CGC TAC ACC TGG GAC TTT GGC ACC GAG GAA 4394 Trp Pro Pro Phe Pro Tyr Arg Tyr Thr Trp Asp Phe Gly Thr Glu Glu 1405 1410 1415 1420 GCC GCC CCC ACC CGT GCC AGG GGC CCT GAG GTG ACG TTC ATC TAC CGA 4442 Ala Ala Pro Thr Arg Ala Arg Gly Pro Glu Val Thr Phe lie Tyr Arg 1425 1430 1435 GAC CCA GGC TCC TAT CTT GTG ACA GTC ACC GCG TCC AAC AAC ATC TCT 4490 Asp Pro Gly Ser Tyr Leu Val Thr Val Thr Ala Ser Asn Asn lie Ser 1440 1445 1450 GCT GCC AAT GAC TCA GCC CTG GTG GAG GTG CAG GAG CCC GTG CTG GTC 4538 Ala Ala Asn Asp Ser Ala Leu Val Glu Val Gin Glu Pro Val Leu Val 1455 1460 1465 ACC AGC ATC AAG GTC AAT GGC TCC CTT GGG CTG GAG CTG CAG CAG CCG 4586 Thr Ser lie Lys Val Asn Gly Ser Leu Gly Leu Glu Leu Gin Gin Pro 1470 1475 1480 TAC CTG TTC TCT GCT GTG GGC CGT GGG CGC CCC GCC AGC TAC CTG TGG 4634 Tyr Leu Phe Ser Ala Val Gly Arg Gly Arg Pro Ala Ser Tyr Leu Trp 1485 1490 1495 1500 GAT CTG GGG GAC GGT GGG TGG CTC GAG GGT CCG GAG GTC ACC CAC GCT 4682 Asp Leu Gly Asp Gly Gly Trp Leu Glu Gly Pro Glu Val Thr His Ala 1505 1510 1515 TAC AAC AGC ACA GGT GAC TTC ACC GTT AGG GTG GCC GGC TGG AAT GAG 4730 Tyr Asn Ser Thr Gly Asp Phe Thr Val Arg Val Ala Gly Trp Asn Glu 1520 1525 1530 GTG AGC CGC AGC GAG GCC TGG CTC AAT GTG ACG GTG AAG CGG CGC GTG 4778 Val Ser Arg Ser Glu Ala Trp Leu Asn Val Thr Val Lys Arg Arg Val 1535 1540 1545 CGG GGG CTC GTC GTC AAT GCA AGC CGC ACG GTG GTG CCC CTG AAT GGG 4826 Arg Gly Leu Val Val Asn Ala Ser Arg Thr Val Val Pro Leu Asn Gly 1550 1555 1560 AGC GTG AGC TTC AGC ACG TCG CTG GAG GCC GGC AGT GAT GTG CGC TAT 4874 Ser Val Ser Phe Ser Thr Ser Leu Glu Ala Gly Ser Asp Val Arg Tyr 1565 1570 1575 1580 TCC TGG GTG CTC TGT GAC CGC TGC ACG CCC ATC CCT GGG GGT CCT ACC 4922 Ser Trp Val Leu Cys Asp Arg Cys Thr Pro lie Pro Gly Gly Pro Thr 1585 1590 1595 ATC TCT TAC ACC TTC CGC TCC GTG GGC ACC TTC AAT ATC ATC GTC ACG 4970 lie Ser Tyr Thr Phe Arg Ser Val Gly Thr Phe Asn lie lie Val Thr 1600 1605 1610 GCT GAG AAC GAG GTG GGC TCC GCC CAG GAC AGC ATC TTC GTC TAT GTC 5018 Ala Glu Asn Glu Val Gly Ser Ala Gin Asp Ser He Phe Val Tyr Val 1615 1620 1625 CTG CAG CTC ATA GAG GGG CTG CAG GTG GTG GGC GGT GGC CGC TAC TTC 5066 Leu Gin Leu He Glu Gly Leu Gin Val Val Gly Gly Gly Arg Tyr Phe 1630 1635 1640 CCC ACC AAC CAC ACG GTA CAG CTG CAG GCC GTG GTT AGG GAT GGC ACC 5114 Pro Thr Asn His Thr Val Gin Leu Gin Ala Val Val Arg Asp Gly Thr 1645 1650 1655 1660 AAC GTC TCC TAC AGC TGG ACT GCC TGG AGG GAC AGG GGC CCG GCC CTG 5162 Asn Val Ser Tyr Ser Trp Thr Ala Trp Arg Asp Arg Gly Pro Ala Leu 1665 1670 1675 GCC GGC AGC GGC AAA GGC TTC TCG CTC ACC GTG CTC GAG GCC GGC ACC 5210 Ala Gly Ser Gly Lys Gly Phe Ser Leu Thr Val Leu Glu Ala Gly Thr 1680 1685 1690 TAC CAT GTG CAG CTG CGG GCC ACC AAC ATG CTG GGC AGC GCC TGG GCC 5258 Tyr His Val Gin Leu Arg Ala Thr Asn Met Leu Gly Ser Ala Trp Ala 1695 1700 1705 GAC TGC ACC ATG GAC TTC GTG GAG CCT GTG GGG TGG CTG ATG GTG GCC 5306 Asp Cys Thr Met Asp Phe Val Glu Pro Val Gly Trp Leu Met Val Ala 1710 1715 1720 GCC TCC CCG AAC CCA GCT GCC GTC AAC ACA AGC GTC ACC CTC AGT GCC 5354 Ala Ser Pro Asn Pro Ala Ala Val Asn Thr Ser Val Thr Leu Ser Ala 1725 1730 1735 1740 GAG CTG GCT GGT GGC AGT GGT GTC GTA TAC ACT TGG TCC TTG GAG GAG 5402 Glu Leu Ala Gly Gly Ser Gly Val Val Tyr Thr Trp Ser Leu Glu Glu 1745 1750 1755 GGG CTG AGC TGG GAG ACC TCC GAG CCA TTT ACC ACC CAT AGC TTC CCC 5450 Gly Leu Ser Trp Glu Thr Ser Glu Pro Phe Thr Thr His Ser Phe Pro 1760 1765 1770 ACA CCC GGC CTG CAC TTG GTC ACC ATG ACG GCA GGG AAC CCG CTG GGC 5498 Thr Pro Gly Leu His Leu Val Thr Met Thr Ala Gly Asn Pro Leu Gly 1775 1780 1785 TCA GCC AAC GCC ACC GTG GAA GTG GAT GTG CAG GTG CCT GTG AGT GGC 5546 Ser Ala Asn Ala Thr Val Glu Val Asp Val Gin Val Pro Val Ser Gly 1790 1795 1800 CTC AGC ATC AGG GCC AGC GAG CCC GGA GGC AGC TTC GTG GCG GCC GGG 5594 Leu Ser He Arg Ala Ser Glu Pro Gly Gly Ser Phe Val Ala Ala Gly 1805 1810 1815 1820 TCC TCT GTG CCC TTT TGG GGG CAG CTG GCC ACG GGC ACC AAT GTG AGC 5642 Ser Ser Val Pro Phe Trp Gly Gin Leu Ala Thr Gly Thr Asn Val Ser 1825 1830 1835 TGG TGC TGG GCT GTG CCC GGC GGC AGC AGC AAG CGT GGC CCT CAT GTC 5690 Trp Cys Trp Ala Val Pro Gly Gly Ser Ser Lys Arg Gly Pro His Val 1840 1845 1850 ACC ATG GTC TTC CCG GAT GCT GGC ACC TTC TCC ATC CGG CTC AAT GCC 5738 Thr Met Val Phe Pro Asp Ala Gly Thr Phe Ser He Arg Leu Asn Ala 1855 1860 1865 TCC AAC GCA GTC AGC TGG GTC TCA GCC ACG TAC AAC CTC ACG GCG GAG 5786 Ser Asn Ala Val Ser Trp Val Ser Ala Thr Tyr Asn Leu Thr Ala Glu 1870 1875 1880 GAG CCC ATC GTG GGC CTG GTG CTG TGG GCC AGC AGC AAG GTG GTG GCG 5834 Glu Pro He Val Gly Leu Val Leu Trp Ala Ser Ser Lys Val Val Ala 1885 1890 1895 1900 CCC GGG CAG CTG GTC CAT TTT CAG ATC CTG CTG GCT GCC GGC TCA GCT 5882 Pro Gly Gin Leu Val His Phe Gin He Leu Leu Ala Ala Gly Ser Ala 1905 1910 1915 GTC ACC TTC CGC CTG CAG GTC GGC GGG GCC AAC CCC GAG GTG CTC CCC 5930 Val Thr Phe Arg Leu Gin Val Gly Gly Ala Asn Pro Glu Val Leu Pro 1920 1925 1930 GGG CCC CGT TTC TCC CAC AGC TTC CCC CGC GTC GGA GAC CAC GTG GTG 5978 Gly Pro Arg Phe Ser His Ser Phe Pro Arg Val Gly Asp His Val Val 1935 1940 1945 AGC GTG CGG GGC AAA AAC CAC GTG AGC TGG GCC CAG GCG CAG GTG CGC 6026 Ser Val Arg Gly Lys Asn His Val Ser Trp Ala Gin Ala Gin Val Arg 1950 1955 1960 ATC GTG GTG CTG GAG GCC GTG AGT GGG CTG CAG GTG CCC AAC TGC TGC 6074 He Val Val Leu Glu Ala Val Ser Gly Leu Gin Val Pro Asn Cys Cys 1965 1970 1975 1980 GAG CCT GGC ATC GCC ACG GGC ACT GAG AGG AAC TTC ACA GCC CGC GTG 6122 Glu Pro Gly He Ala Thr Gly Thr Glu Arg Asn Phe Thr Ala Arg Val 1985 1990 1995 CAG CGC GGC TCT CGG GTC GCC TAC GCC TGG TAC TTC TCG CTG CAG AAG 6170 Gin Arg Gly Ser Arg Val Ala Tyr Ala Trp Tyr Phe Ser Leu Gin Lys 2000 2005 2010 GTC CAG GGC GAC TCG CTG GTC ATC CTG TCG GGC CGC GAC GTC ACC TAC 6218 Val Gin Gly Asp Ser Leu Val He Leu Ser Gly Arg Asp Val Thr Tyr 2015 2020 2025 ACG CCC GTG GCC GCG GGG CTG TTG GAG ATC CAG GTG CGC GCC TTC AAC 6266 Thr Pro Val Ala Ala Gly Leu Leu Glu He Gin Val Arg Ala Phe Asn 2030 2035 2040 GCC CTG GGC AGT GAG AAC CGC ACG CTG GTG CTG GAG GTT CAG GAC GCC 6314 Ala Leu Gly Ser Glu Asn Arg Thr Leu Val Leu Glu Val Gin Asp Ala 2045 2050 2055 2060 GTC CAG TAT GTG GCC CTG CAG AGC GGC CCC TGC TTC ACC AAC CGC TCG 6362 Val Gin Tyr Val Ala Leu Gin Ser Gly Pro Cys Phe Thr Asn Arg Ser 2065 2070 2075 GCG CAG TTT GAG GCC GCC ACC AGC CCC AGC CCC CGG CGT GTG GCC TAC 6410 Ala Gin Phe Glu Ala Ala Thr Ser Pro Ser Pro Arg Arg Val Ala Tyr 2080 2085 2090 CAC TGG GAC TTT GGG GAT GGG TCG CCA GGG CAG GAC ACA GAT GAG CCC 6458 His Trp Asp Phe Gly Asp Gly Ser Pro Gly Gin Asp Thr Asp Glu Pro 2095 2100 2105 AGG GCC GAG CAC TCC TAC CTG AGG CCT GGG GAC TAC CGC GTG CAG GTG 6506 Arg Ala Glu His Ser Tyr Leu Arg Pro Gly Asp Tyr Arg Val Gin Val 2110 2115 2120 AAC GCC TCC AAC CTG GTG AGC TTC TTC GTG GCG CAG GCC ACG GTG ACC 6554 Asn Ala Ser Asn Leu Val Ser Phe Phe Val Ala Gin Ala Thr Val Thr 2125 2130 2135 2140 GTC CAG GTG CTG GCC TGC CGG GAG CCG GAG GTG GAC GTG GTC CTG CCC 6602 Val Gin Val Leu Ala Cys Arg Glu Pro Glu Val Asp Val Val Leu Pro 2145 2150 2155 CTG CAG GTG CTG ATG CGG CGA TCA CAG CGC AAC TAC TTG GAG GCC CAC 6650 Leu Gin Val Leu Met Arg Arg Ser Gin Arg Asn Tyr Leu Glu Ala His 2160 2165 2170 GTT GAC CTG CGC GAC TGC GTC ACC TAC CAG ACT GAG TAC CGC TGG GAG 6698 Val Asp Leu Arg Asp Cys Val Thr Tyr Gin Thr Glu Tyr Arg Trp Glu 2175 2180 2185 GTG TAT CGC ACC GCC AGC TGC CAG CGG CCG GGG CGC CCA GCG CGT GTG 6746 Val Tyr Arg Thr Ala Ser Cys Gin Arg Pro Gly Arg Pro Ala Arg Val 2190 2195 2200 GCC CTG CCC GGC GTG GAC GTG AGC CGG CCT CGG CTG GTG CTG CCG CGG 6794 Ala Leu Pro Gly Val Asp Val Ser Arg Pro Arg Leu Val Leu Pro Arg 2205 2210 2215 2220 CTG GCG CTG CCT GTG GGG CAC TAC TGC TTT GTG TTT GTC GTG TCA TTT 6842 Leu Ala Leu Pro Val Gly His Tyr Cys Phe Val Phe Val Val Ser Phe 2225 2230 2235 GGG GAC ACG CCA CTG ACA CAG AGC ATC CAG GCC AAT GTG ACG GTG GCC 6890 Gly Asp Thr Pro Leu Thr Gin Ser He Gin Ala Asn Val Thr Val Ala 2240 2245 2250 CCC GAG CGC CTG GTG CCC ATC ATT GAG GGT GGC TCA TAC CGC GTG TGG 6938 Pro Glu Arg Leu Val Pro He He Glu Gly Gly Ser Tyr Arg Val Trp 2255 2260 2265 TCA GAC ACA CGG GAC CTG GTG CTG GAT GGG AGC GAG TCC TAC GAC CCC 6986 Ser Asp Thr Arg Asp Leu Val Leu Asp Gly Ser Glu Ser Tyr Asp Pro 2270 2275 2280 AAC CTG GAG GAC GGC GAC CAG ACG CCG CTC AGT TTC CAC TGG GCC TGT 7034 Asn Leu Glu Asp Gly Asp Gin Thr Pro Leu Ser Phe His Trp Ala Cys 2285 2290 2295 2300 GTG GCT TCG ACA CAG AGG GAG GCT GGC GGG TGT GCG CTG AAC TTT GGG 7082 Val Ala Ser Thr Gin Arg Glu Ala Gly Gly Cys Ala Leu Asn Phe Gly 2305 2310 2315 CCC CGC GGG AGC AGC ACG GTC ACC ATT CCA CGG GAG CGG CTG GCG GCT 7130 Pro Arg Gly Ser Ser Thr Val Thr He Pro Arg Glu Arg Leu Ala Ala 2320 2325 2330 GGC GTG GAG TAC ACC TTC AGC CTG ACC GTG TGG AAG GCC GGC CGC AAG 7178 Gly Val Glu Tyr Thr Phe Ser Leu Thr Val Trp Lys Ala Gly Arg Lys 2335 2340 2345 GAG GAG GCC ACC AAC CAG ACG GTG CTG ATC CGG AGT GGC CGG GTG CCC 7226 Glu Glu Ala Thr Asn Gin Thr Val Leu He Arg Ser Gly Arg Val Pro 2350 2355 2360 ATT GTG TCC TTG GAG TGT GTG TCC TGC AAG GCA CAG GCC GTG TAC GAA 7274 He Val Ser Leu Glu Cys Val Ser Cys Lys Ala Gin Ala Val Tyr Glu 2365 2370 2375 2380 GTG AGC CGC AGC TCC TAC GTG TAC TTG GAG GGC CGC TGC CTC AAT TGC 7322 Val Ser Arg Ser Ser Tyr Val Tyr Leu Glu Gly Arg Cys Leu Asn Cys 2385 2390 2395 AGC AGC GGC TCC AAG CGA GGG CGG TGG GCT GCA CGT ACG TTC AGC AAC 7370 Ser Ser Gly Ser Lys Arg Gly Arg Trp Ala Ala Arg Thr Phe Ser Asn 2400 2405 2410 AAG ACG CTG GTG CTG GAT GAG ACC ACC ACA TCC ACG GGC AGT GCA GGC 7418 Lys Thr Leu Val Leu Asp Glu Thr Thr Thr Ser Thr Gly Ser Ala Gly 2415 2420 2425 ATG CGA CTG GTG CTG CGG CGG GGC GTG CTG CGG GAC GGC GAG GGA TAC 7466 Met Arg Leu Val Leu Arg Arg Gly Val Leu Arg Asp Gly Glu Gly Tyr 2430 2435 2440 ACC TTC ACG CTC ACG GTG CTG GGC CGC TCT GGC GAG GAG GAG GGC TGC 7514 Thr Phe Thr Leu Thr Val Leu Gly Arg Ser Gly Glu Glu Glu Gly Cys 2445 2450 2455 2460 GCC TCC ATC CGC CTG TCC CCC AAC CGC CCG CCG CTG GGG GGC TCT TGC 7562 Ala Ser He Arg Leu Ser Pro Asn Arg Pro Pro Leu Gly Gly Ser Cys 2465 2470 2475 CGC CTC TTC CCA CTG GGC GCT GTG CAC GCC CTC ACC ACC AAG GTG CAC 7610 Arg Leu Phe Pro Leu Gly Ala Val His Ala Leu Thr Thr Lys Val His 2480 2485 2490 TTC GAA TGC ACG GGC TGG CAT GAC GCG GAG GAT GCT GGC GCC CCG CTG 7658 Phe Glu Cys Thr Gly Trp His Asp Ala Glu Asp Ala Gly Ala Pro Leu 2495 2500 2505 GTG TAC GCC CTG CTG CTG CGG CGC TGT CGC CAG GGC CAC TGC GAG GAG 7706 Val Tyr Ala Leu Leu Leu Arg Arg Cys Arg Gin Gly His Cys Glu Glu 2510 2515 2520 TTC TGT GTC TAC AAG GGC AGC CTC TCC AGC TAC GGA GCC GTG CTG CCC 7754 Phe Cys Val Tyr Lys Gly Ser Leu Ser Ser Tyr Gly Ala Val Leu Pro 2525 2530 2535 2540 CCG GGT TTC AGG CCA CAC TTC GAG GTG GGC CTG GCC GTG GTG GTG CAG 7802 Pro Gly Phe Arg Pro His Phe Glu Val Gly Leu Ala Val Val Val Gin 2545 2550 2555 GAC CAG CTG GGA GCC GCT GTG GTC GCC CTC AAC AGG TCT TTG GCC ATC 7850 Asp Gin Leu Gly Ala Ala Val Val Ala Leu Asn Arg Ser Leu Ala He 2560 2565 2570 ACC CTC CCA GAG CCC AAC GGC AGC GCA ACG GGG CTC ACA GTC TGG CTG 7898 Thr Leu Pro Glu Pro Asn Gly Ser Ala Thr Gly Leu Thr Val Trp Leu 2575 2580 2585 CAC GGG CTC ACC GCT AGT GTG CTC CCA GGG CTG CTG CGG CAG GCC GAT 7946 His Gly Leu Thr Ala Ser Val Leu Pro Gly Leu Leu Arg Gin Ala Asp 2590 2595 2600 CCC CAG CAC GTC ATC GAG TAC TCG TTG GCC CTG GTC ACC GTG CTG AAC 7994 Pro Gin His Val He Glu Tyr Ser Leu Ala Leu Val Thr Val Leu Asn 2605 2610 2615 2620 GAG TAC GAG CGG GCC CTG GAC GTG GCG GCA GAG CCC AAG CAC GAG CGG 8042 Glu Tyr Glu Arg Ala Leu Asp Val Ala Ala Glu Pro Lys His Glu Arg 2625 2630 2635 CAG CAC CGA GCC CAG ATA CGC AAG AAC ATC ACG GAG ACT CTG GTG TCC 8090 Gin His Arg Ala Gin He Arg Lys Asn He Thr Glu Thr Leu Val Ser 2640 2645 2650 CTG AGG GTC CAC ACT GTG GAT GAC ATC CAG CAG ATC GCT GCT GCG CTG 8138 Leu Arg Val His Thr Val Asp Asp He Gin Gin He Ala Ala Ala Leu 2655 2660 2665 GCC CAG TGC ATG GGG CCC AGC AGG GAG CTC GTA TGC CGC TCG TGC CTG 8186 Ala Gin Cys Met Gly Pro Ser Arg Glu Leu Val Cys Arg Ser Cys Leu 2670 2675 2680 AAG CAG ACG CTG CAC AAG CTG GAG GCC ATG ATG CTC ATC CTG CAG GCA 8234 Lys Gin Thr Leu His Lys Leu Glu Ala Met Met Leu He Leu Gin Ala 2685 2690 2695 2700 GAG ACC ACC GCG GGC ACC GTG ACG CCC ACC GCC ATC GGA GAC AGC ATC 8282 Glu Thr Thr Ala Gly Thr Val Thr Pro Thr Ala He Gly Asp Ser He 2705 2710 2715 CTC AAC ATC ACA GGA GAC CTC ATC CAC CTG GCC AGC TCG GAC GTG CGG 8330 Leu Asn He Thr Gly Asp Leu He His Leu Ala Ser Ser Asp Val Arg 2720 2725 2730 GCA CCA CAG CCC TCA GAG CTG GGA GCC GAG TCA CCA TCT CGG ATG GTG 8378 Ala Pro Gin Pro Ser Glu Leu Gly Ala Glu Ser Pro Ser Arg Met Val 2735 2740 2745 GCG TCC CAG GCC TAC AAC CTG ACC TCT GCC CTC ATG CGC ATC CTC ATG 8426 Ala Ser Gin Ala Tyr Asn Leu Thr Ser Ala Leu Met Arg He Leu Met 2750 2755 2760 CGC TCC CGC GTG CTC AAC GAG GAG CCC CTG ACG CTG GCG GGC GAG GAG 8474 Arg Ser Arg Val Leu Asn Glu Glu Pro Leu Thr Leu Ala Gly Glu Glu 2765 2770 2775 2780 ATC GTG GCC CAG GGC AAG CGC TCG GAC CCG CGG AGC CTG CTG TGC TAT 8522 He Val Ala Gin Gly Lys Arg Ser Asp Pro Arg Ser Leu Leu Cys Tyr 2785 2790 2795 GGC GGC GCC CCA GGG CCT GGC TGC CAC TTC TCC ATC CCC GAG GCT TTC 8570 Gly Gly Ala Pro Gly Pro Gly Cys His Phe Ser He Pro Glu Ala Phe 2800 2805 2810 AGC GGG GCC CTG GCC AAC CTC AGT GAC GTG GTG CAG CTC ATC TTT CTG 8618 Ser Gly Ala Leu Ala Asn Leu Ser Asp Val Val Gin Leu He Phe Leu 2815 2820 2825 GTG GAC TCC AAT CCC TTT CCC TTT GGC TAT ATC AGC AAC TAC ACC GTC 8666 Val Asp Ser Asn Pro Phe Pro Phe Gly Tyr He Ser Asn Tyr Thr Val 2830 2835 2840 TCC ACC AAG GTG GCC TCG ATG GCA TTC CAG ACA CAG GCC GGC GCC CAG 8714 Ser Thr Lys Val Ala Ser Met Ala Phe Gin Thr Gin Ala Gly Ala Gin 2845 2850 2855 2860 ATC CCC ATC GAG CGG CTG GCC TCA GAG CGC GCC ATC ACC GTG AAG GTG 8762 He Pro He Glu Arg Leu Ala Ser Glu Arg Ala He Thr Val Lys Val 2865 2870 2875 CCC AAC AAC TCG GAC TGG GCT GCC CGG GGC CAC CGC AGC TCC GCC AAC 8810 Pro Asn Asn Ser Asp Trp Ala Ala Arg Gly His Arg Ser Ser Ala Asn 2880 2885 2890 TCC GCC AAC TCC GTT GTG GTC CAG CCC CAG GCC TCC GTC GGT GCT GTG 8858 Ser Ala Asn Ser Val Val Val Gin Pro Gin Ala Ser Val Gly Ala Val 2895 2900 2905 GTC ACC CTG GAC AGC AGC AAC CCT GCG GCC GGG CTG CAT CTG CAG CTC 8906 Val Thr Leu Asp Ser Ser Asn Pro Ala Ala Gly Leu His Leu Gin Leu 2910 2915 2920 AAC TAT ACG CTG CTG GAC GGC CAC TAC CTG TCT GAG GAA CCT GAG CCC 8954 Asn Tyr Thr Leu Leu Asp Gly His Tyr Leu Ser Glu Glu Pro Glu Pro 2925 2930 2935 2940 TAC CTG GCA GTC TAC CTA CAC TCG GAG CCC CGG CCC AAT GAG CAC AAC 9002 Tyr Leu Ala Val Tyr Leu His Ser Glu Pro Arg Pro Asn Glu His Asn 2945 2950 2955 TGC TCG GCT AGC AGG AGG ATC CGC CCA GAG TCA CTC CAG GGT GCT GAC 9050 Cys Ser Ala Ser Arg Arg He Arg Pro Glu Ser Leu Gin Gly Ala Asp 2960 2965 2970 CAC CGG CCC TAC ACC TTC TTC ATT TCC CCG GGG AGC AGA GAC CCA GCG 9098 His Arg Pro Tyr Thr Phe Phe He Ser Pro Gly Ser Arg Asp Pro Ala 2975 2980 2985 GGG AGT TAC CAT CTG AAC CTC TCC AGC CAC TTC CGC TGG TCG GCG CTG 9146 Gly Ser Tyr His Leu Asn Leu Ser Ser His Phe Arg Trp Ser Ala Leu 2990 2995 3000 CAG GTG TCC GTG GGC CTG TAC ACG TCC CTG TGC CAG TAC TTC AGC GAG 9194 Gin Val Ser Val Gly Leu Tyr Thr Ser Leu Cys Gin Tyr Phe Ser Glu 3005 3010 3015 3020 GAG GAC ATG GTG TGG CGG ACA GAG GGG CTG CTG CCC CTG GAG GAG ACC 9242 Glu Asp Met Val Trp Arg Thr Glu Gly Leu Leu Pro Leu Glu Glu Thr 3025 3030 3035 TCG CCC CGC CAG GCC GTC TGC CTC ACC CGC CAC CTC ACC GCC TTC GGC 9290 Ser Pro Arg Gin Ala Val Cys Leu Thr Arg His Leu Thr Ala Phe Gly 3040 3045 3050 GCC AGC CTC TTC GTG CCC CCA AGC CAT GTC CGC TTT GTG TTT CCT GAG 9338 Ala Ser Leu Phe Val Pro Pro Ser His Val Arg Phe Val Phe Pro Glu 3055 3060 3065 CCG ACA GCG GAT GTA AAC TAC ATC GTC ATG CTG ACA TGT GCT GTG TGC 9386 Pro Thr Ala Asp Val Asn Tyr He Val Met Leu Thr Cys Ala Val Cys 3070 3075 3080 CTG GTG ACC TAC ATG GTC ATG GCC GCC ATC CTG CAC AAG CTG GAC CAG 9434 Leu Val Thr Tyr Met Val Met Ala Ala He Leu His Lys Leu Asp Gin 3085 3090 3095 3100 TTG GAT GCC AGC CGG GGC CGC GCC ATC CCT TTC TGT GGG CAG CGG GGC 9482 Leu Asp Ala Ser Arg Gly Arg Ala He Pro Phe Cys Gly Gin Arg Gly 3105 3110 3115 CGC TTC AAG TAC GAG ATC CTC GTC AAG ACA GGC TGG GGC CGG GGC TCA 9530 Arg Phe Lys Tyr Glu He Leu Val Lys Thr Gly Trp Gly Arg Gly Ser 3120 3125 3130 GGT ACC ACG GCC CAC GTG GGC ATC ATG CTG TAT GGG GTG GAC AGC CGG 9578 Gly Thr Thr Ala His Val Gly He Met Leu Tyr Gly Val Asp Ser Arg 3135 3140 3145 AGC GGC CAC CGG CAC CTG GAC GGC GAC AGA GCC TTC CAC CGC AAC AGC 9626 Ser Gly His Arg His Leu Asp Gly Asp Arg Ala Phe His Arg Asn Ser 3150 3155 3160 CTG GAC ATC TTC CGG ATC GCC ACC CCG CAC AGC CTG GGT AGC GTG TGG 9674 Leu Asp He Phe Arg He Ala Thr Pro His Ser Leu Gly Ser Val Trp 3165 3170 3175 3180 AAG ATC CGA GTG TGG CAC GAC AAC AAA GGG CTC AGC CCT GCC TGG TTC 9722 Lys He Arg Val Trp His Asp Asn Lys Gly Leu Ser Pro Ala Trp Phe 3185 3190 3195 CTG CAG CAC GTC ATC GTC AGG GAC CTG CAG ACG GCA CGC AGC GCC TTC 9770 Leu Gin His Val He Val Arg Asp Leu Gin Thr Ala Arg Ser Ala Phe 3200 3205 3210 TTC CTG GTC AAT GAC TGG CTT TCG GTG GAG ACG GAG GCC AAC GGG GGC 9818 Phe Leu Val Asn Asp Trp Leu Ser Val Glu Thr Glu Ala Asn Gly Gly 3215 3220 3225 CTG GTG GAG AAG GAG GTG CTG GCC GCG AGC GAC GCA GCC CTT TTG CGC 9866 Leu Val Glu Lys Glu Val Leu Ala Ala Ser Asp Ala Ala Leu Leu Arg 3230 3235 3240 TTC CGG CGC CTG CTG GTG GCT GAG CTG CAG CGT GGC TTC TTT GAC AAG 9914 Phe Arg Arg Leu Leu Val Ala Glu Leu Gin Arg Gly Phe Phe Asp Lys 3245 3250 3255 3260 CAC ATC TGG CTC TCC ATA TGG GAC CGG CCG CCT CGT AGC CGT TTC ACT 9962 His He Trp Leu Ser He Trp Asp Arg Pro Pro Arg Ser Arg Phe Thr 3265 3270 3275 CGC ATC CAG AGG GCC ACC TGC TGC GTT CTC CTC ATC TGC CTC TTC CTG 10010 Arg He Gin Arg Ala Thr Cys Cys Val Leu Leu He Cys Leu Phe Leu 3280 3285 3290 GGC GCC AAC GCC GTG TGG TAC GGG GCT GTT GGC GAC TCT GCC TAC AGC 10058 Gly Ala Asn Ala Val Trp Tyr Gly Ala Val Gly Asp Ser Ala Tyr Ser 3295 3300 3305 ACG GGG CAT GTG TCC AGG CTG AGC CCG CTG AGC GTC GAC ACA GTC GCT 10106 Thr Gly His Val Ser Arg Leu Ser Pro Leu Ser Val Asp Thr Val Ala 3310 3315 3320 GTT GGC CTG GTG TCC AGC GTG GTT GTC TAT CCC GTC TAC CTG GCC ATC 10154 Val Gly Leu Val Ser Ser Val Val Val Tyr Pro Val Tyr Leu Ala He 3325 3330 3335 3340 CTT TTT CTC TTC CGG ATG TCC CGG AGC AAG GTG GCT GGG AGC CCG AGC 10202 Leu Phe Leu Phe Arg Met Ser Arg Ser Lys Val Ala Gly Ser Pro Ser 3345 3350 3355 CCC ACA CCT GCC GGG CAG CAG GTG CTG GΛC ATC GAC AGC TGC CTG GAC 10250 Pro Thr Pro Ala Gly Gin Gin Val Leu Asp He Asp Ser Cys Leu Asp 3360 3365 3370 TCG TCC GTG CTG GAC AGC TCC TTC CTC ACG TTC TCA GGC CTC CAC GCT 10298 Ser Ser Val Leu Asp Ser Ser Phe Leu Thr Phe Ser Gly Leu His Ala 3375 3380 3385 GAG GCC TTT GTT GGA CAG ATG AAG AGT GAC TTG TTT CTG GAT GAT TCT 10346 Glu Ala Phe Val Gly Gin Met Lys Ser Asp Leu Phe Leu Asp Asp Ser 3390 3395 3400 AAG AGT CTG GTG TGC TGG CCC TCC GGC GAG GGA ACG CTC AGT TGG CCG 10394 Lys Ser Leu Val Cys Trp Pro Ser Gly Glu Gly Thr Leu Ser Trp Pro 3405 3410 3415 3420 GAC CTG CTC AGT GAC CCG TCC ATT GTG GGT AGC AAT CTG CGG CAG CTG 10442 Asp Leu Leu Ser Asp Pro Ser He Val Gly Ser Asn Leu Arg Gin Leu 3425 3430 3435 GCA CGG GGC CAG GCG GGC CAT GGG CTG GGC CCA GAG GAG GAC GGC TTC 10490 Ala Arg Gly Gin Ala Gly His Gly Leu Gly Pro Glu Glu Asp Gly Phe 3440 3445 3450 TCC CTG GCC AGC CCC TAC TCG CCT GCC AAA TCC TTC TCA GCA TCA GAT 10538 Ser Leu Ala Ser Pro Tyr Ser Pro Ala Lys Ser Phe Ser Ala Ser Asp 3455 3460 3465 GAA GAC CTG ATC CAG CAG GTC CTT GCC GAG GGG GTC AGC AGC CCA GCC 10586 Glu Asp Leu He Gin Gin Val Leu Ala Glu Gly Val Ser Ser Pro Ala 3470 3475 3480 CCT ACC CAA GAC ACC CAC ATG GAA ACG GAC CTG CTC AGC AGC CTG TCC 10634 Pro Thr Gin Asp Thr His Met Glu Thr Asp Leu Leu Ser Ser Leu Ser 3485 3490 3495 3500 AGC ACT CCT GGG GAG AAG ACA GAG ACG CTG GCG CTG CAG AGG CTG GGG 10682 Ser Thr Pro Gly Glu Lys Thr Glu Thr Leu Ala Leu Gin Arg Leu Gly 3505 3510 3515 GAG CTG GGG CCA CCC AGC CCA GGC CTG AAC TGG GAA CAG CCC CAG GCA 10730 Glu Leu Gly Pro Pro Ser Pro Gly Leu Asn Trp Glu Gin Pro Gin Ala 3520 3525 3530 GCG AGG CTG TCC AGG ACA GGA CTG GTG GAG GGT CTG CGG AAG CGC CTG 10778 Ala Arg Leu Ser Arg Thr Gly Leu Val Glu Gly Leu Arg Lys Arg Leu 3535 3540 3545 CTG CCG GCC TGG TGT GCC TCC CTG GCC CAC GGG CTC AGC CTG CTC CTG 10826 Leu Pro Ala Trp Cys Ala Ser Leu Ala His Gly Leu Ser Leu Leu Leu 3550 3555 3560 GTG GCT GTG GCT GTG GCT GTC TCA GGG TGG GTG GGT GCG AGC TTC CCC 10874 Val Ala Val Ala Val Ala Val Ser Gly Trp Val Gly Ala Ser Phe Pro 3565 3570 3575 3580 CCG GGC GTG AGT GTT GCG TGG CTC CTG TCC AGC AGC GCC AGC TTC CTG 10922 Pro Gly Val Ser Val Ala Trp Leu Leu Ser Ser Ser Ala Ser Phe Leu 3585 3590 3595 GCC TCA TTC CTC GGC TGG GAG CCA CTG AAG GTC TTG CTG GAA GCC CTC 10970 Ala Ser Phe Leu Gly Trp Glu Pro Leu Lys Val Leu Leu Glu Ala Leu 3600 3605 3610 TAC TTC TCA CTG GTG GCC AAG CGG CTG CAC CCG GAT GAA GAT GAC ACC 11018 Tyr Phe Ser Leu Val Ala Lys Arg Leu His Pro Asp Glu Asp Asp Thr 3615 3620 3625 CTG GTA GAG AGC CCG GCT GTG ACG CCT GTG AGC GCA CGT GTG CCC CGC 11066 Leu Val Glu Ser Pro Ala Val Thr Pro Val Ser Ala Arg Val Pro Arg 3630 3635 3640 GTA CGG CCA CCC CAC GGC TTT GCA CTC TTC CTG GCC AAG GAA GAA GCC 11114 Val Arg Pro Pro His Gly Phe Ala Leu Phe Leu Ala Lys Glu Glu Ala 3645 3650 3655 3660 CGC AAG GTC AAG AGG CTA CAT GGC ATG CTG CGG AGC CTC CTG GTG TAC 11162 Arg Lys Val Lys Arg Leu His Gly Met Leu Arg Ser Leu Leu Val Tyr 3665 3670 3675 ATG CTT TTT CTG CTG GTG ACC CTG CTG GCC AGC TAT GGG GAT GCC TCA 11210 Met Leu Phe Leu Leu Val Thr Leu Leu Ala Ser Tyr Gly Asp Ala Ser 3680 3685 3690 TGC CAT GGG CAC GCC TAC CGT CTG CAA AGC GCC ATC AAG CAG GAG CTG 11258 Cys His Gly His Ala Tyr Arg Leu Gin Ser Ala He Lys Gin Glu Leu 3695 3700 3705 CAC AGC CGG GCC TTC CTG GCC ATC ACG CGG TCT GAG GAG CTC TGG CCA 11306 His Ser Arg Ala Phe Leu Ala He Thr Arg Ser Glu Glu Leu Trp Pro 3710 3715 3720 TGG ATG GCC CAC GTG CTG CTG CCC TAC GTC CAC GGG AAC CAG TCC AGC 11354 Trp Met Ala His Val Leu Leu Pro Tyr Val His Gly Asn Gin Ser Ser 3725 3730 3735 3740 CCA GAG CTG GGG CCC CCA CGG CTG CGG CAG GTG CGG CTG CAG GAA GCA 11402 Pro Glu Leu Gly Pro Pro Arg Leu Arg Gin Val Arg Leu Gin Glu Ala 3745 3750 3755 CTC TAC CCA GAC CCT CCC GGC CCC AGG GTC CAC ACG TGC TCG GCC GCA 11450 Leu Tyr Pro Asp Pro Pro Gly Pro Arg Val His Thr Cys Ser Ala Ala 3760 3765 3770 GGA GGC TTC AGC ACC AGC GAT TAC GAC GTT GGC TGG GAG AGT CCT CAC 11498 Gly Gly Phe Ser Thr Ser Asp Tyr Asp Val Gly Trp Glu Ser Pro His 3775 3780 3785 AAT GGC TCG GGG ACG TGG GCC TAT TCA GCG CCG GAT CTG CTG GGG GCA 11546 Asn Gly Ser Gly Thr Trp Ala Tyr Ser Ala Pro Asp Leu Leu Gly Ala 3790 3795 3800 TGG TCC TGG GGC TCC TGT GCC GTG TAT GAC AGC GGG GGC TAC GTG CAG 11594 Trp Ser Trp Gly Ser Cys Ala Val Tyr Asp Ser Gly Gly Tyr Val Gin 3805 3810 3815 3820 GAG CTG GGC CTG AGC CTG GAG GAG AGC CGC GAC CGG CTG CGC TTC CTG 11642 Glu Leu Gly Leu Ser Leu Glu Glu Ser Arg Asp Arg Leu Arg Phe Leu 3825 3830 3835 CAG CTG CAC AAC TGG CTG GAC AAC AGG AGC CGC GCT GTG TTC CTG GAG 11690 Gin Leu His Asn Trp Leu Asp Asn Arg Ser Arg Ala Val Phe Leu Glu 3840 3845 3850 CTC ACG CGC TAC AGC CCG GCC GTG GGG CTG CAC GCC GCC GTC ACG CTG 11738 Leu Thr Arg Tyr Ser Pro Ala Val Gly Leu His Ala Ala Val Thr Leu 3855 3860 3865 CGC CTC GAG TTC CCG GCG GCC GGC CGC GCC CTG GCC GCC CTC AGC GTC 11786 Arg Leu Glu Phe Pro Ala Ala Gly Arg Ala Leu Ala Ala Leu Ser Val 3870 3875 3880 CGC CCC TTT GCG CTG CGC CGC CTC AGC GCG GGC CTC TCG CTG CCT CTG 11834 Arg Pro Phe Ala Leu Arg Arg Leu Ser Ala Gly Leu Ser Leu Pro Leu 3885 3890 3895 3900 CTC ACC TCG GTG TGC CTG CTG CTG TTC GCC GTG CAC TTC GCC GTG GCC 11882 Leu Thr Ser Val Cys Leu Leu Leu Phe Ala Val His Phe Ala Val Ala 3905 3910 3915 GAG GCC CGT ACT TGG CAC AGG GAA GGG CGC TGG CGC GTG CTG CGG CTC 11930 Glu Ala Arg Thr Trp His Arg Glu Gly Arg Trp Arg Val Leu Arg Leu 3920 3925 3930 GGA GCC TGG GCG CGG TGG CTG CTG GTG GCG CTG ACG GCG GCC ACG GCA 11978 Gly Ala Trp Ala Arg Trp Leu Leu Val Ala Leu Thr Ala Ala Thr Ala 3935 3940 3945 CTG GTA CGC CTC GCC CAG CTG GGT GCC GCT GAC CGC CAG TGG ACC CGT 12026 Leu Val Arg Leu Ala Gin Leu Gly Ala Ala Asp Arg Gin Trp Thr Arg 3950 3955 3960 TTC GTG CGC GGC CGC CCG CGC CGC TTC ACT AGC TTC GAC CAG GTG GCG 12074 Phe Val Arg Gly Arg Pro Arg Arg Phe Thr Ser Phe Asp Gin Val Ala 3965 3970 3975 3980 CAG CTG AGC TCC GCA GCC CGT GGC CTG GCG GCC TCG CTG CTC TTC CTG 12122 Gin Leu Ser Ser Ala Ala Arg Gly Leu Ala Ala Ser Leu Leu Phe Leu 3985 3990 3995 CTT TTG GTC AAG GCT GCC CAG CAG CTA CGC TTC GTG CGC CAG TGG TCC 12170 Leu Leu Val Lys Ala Ala Gin Gin Leu Arg Phe Val Arg Gin Trp Ser 4000 4005 4010 GTC TTT GGC AAG ACA TTA TGC CGA GCT CTG CCA GAG CTC CTG GGG GTC 12218 Val Phe Gly Lys Thr Leu Cys Arg Ala Leu Pro Glu Leu Leu Gly Val 4015 4020 4025 ACC TTG GGC CTG GTG GTG CTC GGG GTA GCC TAC GCC CAG CTG GCC ATC 12266 Thr Leu Gly Leu Val Val Leu Gly Val Ala Tyr Ala Gin Leu Ala He 4030 4035 4040 CTG CTC GTG TCT TCC TGT GTG GAC TCC CTC TGG AGC GTG GCC CAG GCC 12314 Leu Leu Val Ser Ser Cys Val Asp Ser Leu Trp Ser Val Ala Gin Ala 4045 4050 4055 4060 CTG TTG GTG CTG TGC CCT GGG ACT GGG CTC TCT ACC CTG TGT CCT GCC 12362 Leu Leu Val Leu Cys Pro Gly Thr Gly Leu Ser Thr Leu Cys Pro Ala 4065 4070 4075 GAG TCC TGG CAC CTG TCA CCC CTG CTG TGT GTG GGG CTC TGG GCA CTG 12410 Glu Ser Trp His Leu Ser Pro Leu Leu Cys Val Gly Leu Trp Ala Leu 4080 4085 4090 CGG CTG TGG GGC GCC CTA CGG CTG GGG GCT GTT ATT CTC CGC TGG CGC 12458 Arg Leu Trp Gly Ala Leu Arg Leu Gly Ala Val He Leu Arg Trp Arg 4095 4100 4105 TAC CAC GCC TTG CGT GGA GAG CTG TAC CGG CCG GCC TGG GAG CCC CAG 12506 Tyr His Ala Leu Arg Gly Glu Leu Tyr Arg Pro Ala Trp Glu Pro Gin 4110 4115 4120 GAC TAC GAG ATG GTG GAG TTG TTC CTG CGC AGG CTG CGC CTC TGG ATG 12554 Asp Tyr Glu Mec Val Glu Leu Phe Leu Arg Arg Leu Arg Leu Trp Met 4125 4130 4135 4140 GGC CTC AGC AAG GTC AAG GAG TTC CGC CAC AAA GTC CGC TTT GAA GGG 12602 Gly Leu Ser Lys Val Lys Glu Phe Arg His Lys Val Arg Phe Glu Gly 4145 4150 4155 ATG GAG CCG CTG CCC TCT CGC TCC TCC AGG GGC TCC AAG GTA TCC CCG 12650 Met Glu Pro Leu Pro Ser Arg Ser Ser Arg Gly Ser Lys Val Ser Pro 4160 4165 4170 GAT GTG CCC CCA CCC AGC GCT GGC TCC GAT GCC TCG CAC CCC TCC ACC 12698 Asp Val Pro Pro Pro Ser Ala Gly Ser Asp Ala Ser His Pro Ser Thr 4175 4180 4185 TCC TCC AGC CAG CTG GAT GGG CTG AGC GTG AGC CTG GGC CGG CTG GGG 12746 Ser Ser Ser Gin Leu Asp Gly Leu Ser Val Ser Leu Gly Arg Leu Gly 4190 4195 4200 ACA AGG TGT GAG CCT GAG CCC TCC CGC CTC CAA GCC GTG TTC GAG GCC 12794 Thr Arg Cys Glu Pro Glu Pro Ser Arg Leu Gin Ala Val Phe Glu Ala 4205 4210 4215 4220 CTG CTC ACC CAG TTT GAC CGA CTC AAC CAG GCC ACA GAG GAC GTC TAC 12842 Leu Leu Thr Gin Phe Asp Arg Leu Asn Gin Ala Thr Glu Asp Val Tyr 4225 4230 4235 CAG CTG GAG CAG CAG CTG CAC AGC CTG CAA GGC CGC AGG AGC AGC CGG 12890 Gin Leu Glu Gin Gin Leu His Ser Leu Gin Gly Arg Arg Ser Ser Arg 4240 4245 4250 GCG CCC GCC GGA TCT TCC CGT GGC CCA TCC CCG GGC CTG CGG CCA GCA 12938 Ala Pro Ala Gly Ser Ser Arg Gly Pro Ser Pro Gly Leu Arg Pro Ala 4255 4260 4265 CTG CCC AGC CGC CTT GCC CGG GCC AGT CGG GGT GTG GAC CTG GCC ACT 12986 Leu Pro Ser Arg Leu Ala Arg Ala Ser Arg Gly Val Asp Leu Ala Thr 4270 4275 4280 GGC CCC AGC AGG ACA CCC CTT CGG GCC AAG AAC AAG GTC CAC CCC AGC 13034 Gly Pro Ser Arg Thr Pro Leu Arg Ala Lys Asn Lys Val His Pro Ser 4285 4290 4295 4300 AGC ACT TAGTCCTCCT TCCTGGCGGG GGTGGGCCGT GGAGTCGGAG TGGACACCGC 13090 Ser Thr TCAGTATTAC TTTCTGCCGC TGTCAAGGCC GAGGGCCAGG CAGAATGGCT GCACGTAGGT 13150 TCCCCAGAGA GCAGGCAGGG GCATCTGTCT GTCTGTGGGC TTCAGCACTT TΛAAGAGGCT 13210 GTGTGGCCAA CCAGGACCCA GGGTCCCCTC CCCAGCTCCC TTGGGAAGGA CACAGCAGTA 13270 TTGGACGGTT TCTAGCCTCT GAGATGCTAA TTTATTTCCC CGAGTCCTCA GGTACAGCGG 13330 GCTGTGCCCG GCCCCACCCC CTGGGCAGAT GTCCCCCACT GCTAAGGCTG CTGGCTTCAG 13390 GGAGGGTTAG CCTGCACCGC CGCCACCCTG CCCCTAAGTT ATTACCTCTC CAGTTCCTAC 13450 CGTACTCCCT GCACCGTCTC ACTGTGTGTC TCGTGTCAGT AATTTATATG GTGTTAAAAT 13510 GTGTATATTT TTGTATGTCA CTATTTTCAC TAGGGCTGAG GGGCCTGCGC CCAGAGCTGG 13570 CCTCCCCCAA CACCTGCTGC GCTTGGTAGG TGTGGTGGCG TTATGGCAGC CCGGCTGCTG 13630 CTTGGATGCG AGCTTGGCCT TGGGCCGGTG CTGGGGGCAC AGCTGTCTGC CAGGCACTCT 13690 CATCACCCCA GAGGCCTTGT CATCCTCCCT TGCCCCAGGC CAGGTAGCAA GAGAGCAGCG 13750 CCCAGGCCTG CTGGCATCAG GTCTGGGCAA GTAGCAGGAC TAGGCATGTC AGAGGACCCC 13810 AGGGTGGTTA GAGGAAAAGA CTCCTCCTGG GGGCTGGCTC CCAGGGTGGA GGAAGGTGAC 13870 TGTGTGTGTG TGTGTGTGCG CGCGCGCACG CGCGAGTGTG CTGTATGGCC CAGGCAGCCT 13930 CAAGGCCCTC GGAGCTGGCT GTGCCTGCTT CTGTGTACCA CTTCTGTGGG CATGGCCGCT 13990 TCTAGAGCCT CGACACCCCC CCAACCCCCG CACCAAGCAG ACAAAGTCAA TAAAAGAGCT 14050 GTCTGACTGC 14060 (2) INFORMATION FOR SEQ ID NO:5: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4302 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 5: Met Pro Pro Ala Ala Pro Ala Arg Leu Ala Leu Ala Leu Gly Leu Gly 1 5 10 15 Leu Trp Leu Gly Ala Leu Ala Gly Gly Pro Gly Arg Gly Cys Gly Pro 20 25 30 Cys Glu Pro Pro Cys Leu Cys Gly Pro Ala Pro Gly Ala Ala Cys Arg 35 40 45 Val Asn Cys Ser Gly Arg Gly Leu Arg Thr Leu Gly Pro Ala Leu Arg 50 55 60 He Pro Ala Asp Ala Thr Ala Leu Asp Val Ser His Asn Leu Leu Arg 65 70 75 80 Ala Leu Asp Val Gly Leu Leu Ala Asn Leu Ser Ala Leu Ala Glu Leu 85 90 95 Asp He Ser Asn Asn Lys He Ser Thr Leu Glu Glu Gly He Phe Ala 100 105 110 Asn Leu Phe Asn Leu Ser Glu He Asn Leu Ser Gly Asn Pro Phe Glu 115 120 125 Cys Asp Cys Gly Leu Ala Trp Leu Pro Arg Trp Ala Glu Glu Gin Gin 130 135 140 Val Arg Val Val Gin Pro Glu Ala Ala Thr Cys Ala Gly Pro Gly Ser 145 150 155 160 Leu Ala Gly Gin Pro Leu Leu Gly He Pro Leu Leu Asp Ser Gly Cys 165 170 175 Gly Glu Glu Tyr Val Ala Cys Leu Pro Asp Asn Ser Ser Gly Thr Val 180 185 190 Ala Ala Val Ser Phe Ser Ala Ala His Glu Gly Leu Leu Gin Pro Glu 195 200 205 Ala Cys Ser Ala Phe Cys Phe Ser Thr Gly Gin Gly Leu Ala Ala Leu 210 215 220 Ser Glu Gin Gly Trp Cys Leu Cys Gly Ala Ala Gin Pro Ser Ser Ala 225 230 235 240 Ser Phe Ala Cys Leu Ser Leu Cys Ser Gly Pro Pro Pro Pro Pro Ala 245 250 255 Pro Thr Cys Arg Gly Pro Thr Leu Leu Gin His Val Phe Pro Ala Ser 260 265 270 Pro Gly Ala Thr Leu Val Gly Pro His Gly Pro Leu Ala Ser Gly Gin 275 280 285 Leu Ala Ala Phe His He Ala Ala Pro Leu Pro Val Thr Ala Thr Arg 290 295 300 Trp Asp Phe Gly Asp Gly Ser Ala Glu Val Asp Ala Ala Gly Pro Ala 305 310 315 320 Ala Ser His Arg Tyr Val Leu Pro Gly Arg Tyr His Val Thr Ala Val 325 330 335 Leu Ala Leu Gly Ala Gly Ser Ala Leu Leu Gly Thr Asp Val Gin Val 340 345 350 Glu Ala Ala Pro Ala Ala Leu Glu Leu Val Cys Pro Ser Ser Val Gin 355 360 365 Ser Asp Glu Ser Leu Asp Leu Ser He Gin Asn Arg Gly Gly Ser Gly 370 375 380 Leu Glu Ala Ala Tyr Ser He Val Ala Leu Gly Glu Glu Pro Ala Arg 385 390 395 400 Ala Val His Pro Leu Cys Pro Ser Asp Thr Glu He Phe Pro Gly Asn 405 410 415 Gly His Cys Tyr Arg Leu Val Val Glu Lys Ala Ala Trp Leu Gin Ala 420 425 430 Gin Glu Gin Cys Gin Ala Trp Ala Gly Ala Ala Leu Ala Met Val Asp 435 440 445 Ser Pro Ala Val Gin Arg Phe Leu Val Ser Arg Val Thr Arg Cys Leu 450 455 460 Asp Val Trp He Gly Phe Ser Thr Val Gin Gly Val Glu Val Gly Pro 465 470 475 480 Ala Pro Gin Gly Glu Ala Phe Ser Leu Glu Ser Cys Gin Asn Trp Leu 485 490 495 Pro Gly Glu Pro His Pro Ala Thr Ala Glu His Cys Val Arg Leu Gly 500 505 510 Pro Thr Gly Trp Cys Asn Thr Asp Leu Cys Ser Ala Pro His Ser Tyr 515 520 525 Val Cys Glu Leu Gin Pro Gly Gly Pro Val Gin Asp Ala Glu Asn Leu 530 535 540 Leu Val Gly Ala Pro Ser Gly Asp Leu Gin Gly Pro Leu Thr Pro Leu 545 550 555 560 Ala Gin Gin Asp Gly Leu Ser Ala Pro His Glu Pro Val Glu Val Met 565 570 575 Val Phe Pro Gly Leu Arg Leu Ser Arg Glu Ala Phe Leu Thr Thr Ala 580 585 590 Glu Phe Gly Thr Gin Glu Leu Arg Arg Pro Ala Gin Leu Arg Leu Gin 595 600 605 Val Tyr Arg Leu Leu Ser Thr Ala Gly Thr Pro Glu Asn Gly Ser Glu 610 615 620 Pro Glu Ser Arg Ser Pro Asp Asn Arg Thr Gin Leu Ala Pro Ala Cys 625 630 635 640 Met Pro Gly Gly Arg Trp Cys Pro Gly Ala Asn He Cys Leu Pro Leu 645 650 655 Asp Ala Ser Cys His Pro Gin Ala Cys Ala Asn Gly Cys Thr Ser Gly 660 665 670 Pro Gly Leu Pro Gly Ala Pro Tyr Ala Leu Trp Arg Glu Phe Leu Phe 675 680 685 Ser Val Pro Ala Gly Pro Pro Ala Gin Tyr Ser Val Thr Leu His Gly 690 695 700 Gin Asp Val Leu Met Leu Pro Gly Asp Leu Val Gly Leu Gin His Asp 705 710 715 720 Ala Gly Pro Gly Ala Leu Leu His Cys Ser Pro Ala Pro Gly His Pro 725 730 735 Gly Pro Arg Ala Pro Tyr Leu Ser Ala Asn Ala Ser Ser Trp Leu Pro 740 745 750 His Leu Pro Ala Gin Leu Glu Gly Thr Trp Ala Cys Pro Ala Cys Ala 755 760 765 Leu Arg Leu Leu Ala Ala Thr Glu Gin Leu Thr Val Leu Leu Gly Leu 770 775 780 Arg Pro Asn Pro Gly Leu Arg Leu Pro Gly Arg Tyr Glu Val Arg Ala 785 790 795 800 Glu Val Gly Asn Gly Val Ser Arg His Asn Leu Ser Cys Ser Phe Asp 805 810 815 Val Val Ser Pro Val Ala Gly Leu Arg Val He Tyr Pro Ala Pro Arg 820 825 830 Asp Gly Arg Leu Tyr Val Pro Thr Asn Gly Ser Ala Leu Val Leu Gin 835 840 845 Val Asp Ser Gly Ala Asn Ala Thr Ala Thr Ala Arg Trp Pro Gly Gly 850 855 860 Ser Val Ser Ala Arg Phe Glu Asn Val Cys Pro Ala Leu Val Ala Thr 865 870 875 880 Phe Val Pro Gly Cys Pro Trp Glu Thr Asn Asp Thr Leu Phe Ser Val 885 890 895 Val Ala Leu Pro Trp Leu Ser Glu Gly Glu His Val Val Asp Val Val 900 905 910 Val Glu Asn Ser Ala Ser Arg Ala Asn Leu Ser Leu Arg Val Thr Ala 915 920 925 Glu Glu Pro He Cys Gly Leu Arg Ala Thr Pro Ser Pro Glu Ala Arg 930 935 940 Val Leu Gin Gly Val Leu Val Arg Tyr Ser Pro Val Val Glu Ala Gly 945 950 955 960 Ser Asp Met Val Phe Arg Trp Thr He Asn Asp Lys Gin Ser Leu Thr 965 970 975 Phe Gin Asn Val Val Phe Asn Val He Tyr Gin Ser Ala Ala Val Phe 980 985 990 Lys Leu Ser Leu Thr Ala Ser Asn His Val Ser Asn Val Thr Val Asn 995 1000 1005 Tyr Asn Val Thr Val Glu Arg Met Asn Arg Met Gin Gly Leu Gin Val 1010 1015 1020 Ser Thr Val Pro Ala Val Leu Ser Pro Asn Ala Thr Leu Ala Leu Thr 1025 1030 1035 1040 Ala Gly Val Leu Val Asp Ser Ala Val Glu Val Ala Phe Leu Trp Thr 1045 1050 1055 Phe Gly Asp Gly Glu Gin Ala Leu His Gin Phe Gin Pro Pro Tyr Asn 1060 1065 1070 Glu Ser Phe Pro Val Pro Asp Pro Ser Val Ala Gin Val Leu Val Glu 1075 1080 1085 His Asn Val Met His Thr Tyr Ala Ala Pro Gly Glu Tyr Leu Leu Thr 1090 1095 1100 Val Leu Ala Ser Asn Ala Phe Glu Asn Leu Thr Gin Gin Val Pro Val 1105 1110 1115 1120 Ser Val Arg Ala Ser Leu Pro Ser Val Ala Val Gly Val Ser Asp Gly 1125 1130 1135 Val Leu Val Ala Gly Arg Pro Val Thr Phe Tyr Pro His Pro Leu Pro 1140 1145 1150 Ser Pro Gly Gly Val Leu Tyr Thr Trp Asp Phe Gly Asp Gly Ser Pro 1155 1160 1165 Val Leu Thr Gin Ser Gin Pro Ala Ala Asn His Thr Tyr Ala Ser Arg 1170 1175 1180 Gly Thr Tyr His Val Arg Leu Glu Val Asn Asn Thr Val Ser Gly Ala 1185 1190 1195 1200 Ala Ala Gin Ala Asp Val Arg Val Phe Glu Glu Leu Arg Gly Leu Ser 1205 1210 1215 Val Asp Met Ser Leu Ala Val Glu Gin Gly Ala Pro Val Val Val Ser 1220 1225 1230 Ala Ala Val Gin Thr Gly Asp Asn He Thr Trp Thr Phe Asp Met Gly 1235 1240 1245 Asp Gly Thr Val Leu Ser Gly Pro Glu Ala Thr Val Glu His Val Tyr 1250 1255 1260 Leu Arg Ala Gin Asn Cys Thr Val Thr Val Gly Ala Ala Ser Pro Ala 1265 1270 1275 1280 Gly His Leu Ala Arg Ser Leu His Val Leu Val Phe Val Leu Glu Val 1285 1290 1295 Leu Arg Val Glu Pro Ala Ala Cys He Pro Thr Gin Pro Asp Ala Arg 1300 1305 1310 Leu Thr Ala Tyr Val Thr Gly Asn Pro Ala His Tyr Leu Phe Asp Trp 1315 1320 1325 Thr Phe Gly Asp Gly Ser Ser Asn Thr Thr Val Arg Gly Cys Pro Thr 1330 1335 1340 Val Thr His Asn Phe Thr Arg Ser Gly Thr Phe Pro Leu Ala Leu Val 1345 1350 1355 1360 Leu Ser Ser Arg Val Asn Arg Ala His Tyr Phe Thr Ser He Cys Val 1365 1370 1375 Glu Pro Glu Val Gly Asn Val Thr Leu Gin Pro Glu Arg Gin Phe Val 1380 1385 1390 Gin Leu Gly Asp Glu Ala Trp Leu Val Ala Cys Ala Trp Pro Pro Phe 1395 1400 1405 Pro Tyr Arg Tyr Thr Trp Asp Phe Gly Thr Glu Glu Ala Ala Pro Thr 1410 1415 1420 Arg Ala Arg Gly Pro Glu Val Thr Phe He Tyr Arg Asp Pro Gly Ser 1425 1430 1435 1440 Tyr Leu Val Thr Val Thr Ala Ser Asn Asn He Ser Ala Ala Asn Asp 1445 1450 1455 Ser Ala Leu Val Glu Val Gin Glu Pro Val Leu Val Thr Ser He Lys 1460 1465 1470 Val Asn Gly Ser Leu Gly Leu Glu Leu Gin Gin Pro Tyr Leu Phe Ser 1475 1480 1485 Ala Val Gly Arg Gly Arg Pro Ala Ser Tyr Leu Trp Asp Leu Gly Asp 1490 1495 1500 Gly Gly Trp Leu Glu Gly Pro Glu Val Thr His Ala Tyr Asn Ser Thr 1505 1510 1515 1520 Gly Asp Phe Thr Val Arg Val Ala Gly Trp Asn Glu Val Ser Arg Ser 1525 1530 1535 Glu Ala Trp Leu Asn Val Thr Val Lys Arg Arg Val Arg Gly Leu Val 1540 1545 1550 Val Asn Ala Ser Arg Thr Val Val Pro Leu Asn Gly Ser Val Ser Phe 1555 1560 1565 Ser Thr Ser Leu Glu Ala Gly Ser Asp Val Arg Tyr Ser Trp Val Leu 1570 1575 1580 Cys Asp Arg Cys Thr Pro He Pro Gly Gly Pro Thr He Ser Tyr Thr 1585 1590 1595 1600 Phe Arg Ser Val Gly Thr Phe Asn He He Val Thr Ala Glu Asn Glu 1605 1610 1615 Val Gly Ser Ala Gin Asp Ser He Phe Val Tyr Val Leu Gin Leu He 1620 1625 1630 Glu Gly Leu Gin Val Val Gly Gly Gly Arg Tyr Phe Pro Thr Asn His 1635 1640 1645 Thr Val Gin Leu Gin Ala Val Val Arg Asp Gly Thr Asn Val Ser Tyr 1650 1655 1660 Ser Trp Thr Ala Trp Arg Asp Arg Gly Pro Ala Leu Ala Gly Ser Gly 1665 1670 1675 1680 Lys Gly Phe Ser Leu Thr Val Leu Glu Ala Gly Thr Tyr His Val Gin 1685 1690 1695 Leu Arg Ala Thr Asn Met Leu Gly Ser Ala Trp Ala Asp Cys Thr Met 1700 1705 1710 Asp Phe Val Glu Pro Val Gly Trp Leu Met Val Ala Ala Ser Pro Asn 1715 1720 1725 Pro Ala Ala Val Asn Thr Ser Val Thr Leu Ser Ala Glu Leu Ala Gly 1730 1735 1740 Gly Ser Gly Val Val Tyr Thr Trp Ser Leu Glu Glu Gly Leu Ser Trp 1745 1750 1755 1760 Glu Thr Ser Glu Pro Phe Thr Thr His Ser Phe Pro Thr Pro Gly Leu 1765 1770 1775 His Leu Val Thr Met Thr Ala Gly Asn Pro Leu Gly Ser Ala Asn Ala 1780 1785 1790 Thr Val Glu Val Asp Val Gin Val Pro Val Ser Gly Leu Ser He Arg 1795 1800 1805 Ala Ser Glu Pro Gly Gly Ser Phe Val Ala Ala Gly Ser Ser Val Pro 1810 1815 1820 Phe Trp Gly Gin Leu Ala Thr Gly Thr Asn Val Ser Trp Cys Trp Ala 1825 1830 1835 1840 Val Pro Gly Gly Ser Ser Lys Arg Gly Pro His Val Thr Met Val Phe 1845 1850 1855 Pro Asp Ala Gly Thr Phe Ser He Arg Leu Asn Ala Ser Asn Ala Val 1860 1865 1870 Ser Trp Val Ser Ala Thr Tyr Asn Leu Thr Ala Glu Glu Pro He Val 1875 1880 1885 Gly Leu Val Leu Trp Ala Ser Ser Lys Val Val Ala Pro Gly Gin Leu 1890 1895 1900 Val His Phe Gin He Leu Leu Ala Ala Gly Ser Ala Val Thr Phe Arg 1905 1910 1915 1920 Leu Gin Val Gly Gly Ala Asn Pro Glu Val Leu Pro Gly Pro Arg Phe 1925 1930 1935 Ser His Ser Phe Pro Arg Val Gly Asp His Val Val Ser Val Arg Gly 1940 1945 1950 Lys Asn His Val Ser Trp Ala Gin Ala Gin Val Arg He Val Val Leu 1955 1960 1965 Glu Ala Val Ser Gly Leu Gin Val Pro Asn Cys Cys Glu Pro Gly He 1970 1975 1980 Ala Thr Gly Thr Glu Arg Asn Phe Thr Ala Arg Val Gin Arg Gly Ser 1985 1990 1995 2000 Arg Val Ala Tyr Ala Trp Tyr Phe Ser Leu Gin Lys Val Gin Gly Asp 2005 2010 2015 Ser Leu Val He Leu Ser Gly Arg Asp Val Thr Tyr Thr Pro Val Ala 2020 2025 2030 Ala Gly Leu Leu Glu He Gin Val Arg Ala Phe Asn Ala Leu Gly Ser 2035 2040 2045 Glu Asn Arg Thr Leu Val Leu Glu Val Gin Asp Ala Val Gin Tyr Val 2050 2055 2060 Ala Leu Gin Ser Gly Pro Cys Phe Thr Asn Arg Ser Ala Gin Phe Glu 2065 2070 2075 2080 Ala Ala Thr Ser Pro Ser Pro Arg Arg Val Ala Tyr His Trp Asp Phe 2085 2090 2095 Gly Asp Gly Ser Pro Gly Gin Asp Thr Asp Glu Pro Arg Ala Glu His 2100 2105 2110 Ser Tyr Leu Arg Pro Gly Asp Tyr Arg Val Gin Val Asn Ala Ser Asn 2115 2120 2125 Leu Val Ser Phe Phe Val Ala Gin Ala Thr Val Thr Val Gin Val Leu 2130 2135 2140 Ala Cys Arg Glu Pro Glu Val Asp Val Val Leu Pro Leu Gin Val Leu 2145 2150 2155 2160 Met Arg Arg Ser Gin Arg Asn Tyr Leu Glu Ala His Val Asp Leu Arg 2165 2170 2175 Asp Cys Val Thr Tyr Gin Thr Glu Tyr Arg Trp Glu Val Tyr Arg Thr 2180 2185 2190 Ala Ser Cys Gin Arg Pro Gly Arg Pro Ala Arg Val Ala Leu Pro Gly 2195 2200 2205 Val Asp Val Ser Arg Pro Arg Leu Val Leu Pro Arg Leu Ala Leu Pro 2210 2215 2220 Val Gly His Tyr Cys Phe Val Phe Val Val Ser Phe Gly Asp Thr Pro 2225 2230 2235 2240 Leu Thr Gin Ser He Gin Ala Asn Val Thr Val Ala Pro Glu Arg Leu 2245 2250 2255 Val Pro He He Glu Gly Gly Ser Tyr Arg Val Trp Ser Asp Thr Arg 2260 2265 2270 Asp Leu Val Leu Asp Gly Ser Glu Ser Tyr Asp Pro Asn Leu Glu Asp 2275 2280 2285 Gly Asp Gin Thr Pro Leu Ser Phe His Trp Ala Cys Val Ala Ser Thr 2290 2295 2300 Gin Arg Glu Ala Gly Gly Cys Ala Leu Asn Phe Gly Pro Arg Gly Ser 2305 2310 2315 2320 Ser Thr Val Thr He Pro Arg Glu Arg Leu Ala Ala Gly Val Glu Tyr 2325 2330 2335 Thr Phe Ser Leu Thr Val Trp Lys Ala Gly Arg Lys Glu Glu Ala Thr 2340 2345 2350 Asn Gin Thr Val Leu He Arg Ser Gly Arg Val Pro He Val Ser Leu 2355 2360 2365 Glu Cys Val Ser Cys Lys Ala Gin Ala Val Tyr Glu Val Ser Arg Ser 2370 2375 2380 Ser Tyr Val Tyr Leu Glu Gly Arg Cys Leu Asn Cys Ser Ser Gly Ser 2385 2390 2395 2400 Lys Arg Gly Arg Trp Ala Ala Arg Thr Phe Ser Asn Lys Thr Leu Val 2405 2410 2415 Leu Asp Glu Thr Thr Thr Ser Thr Gly Ser Ala Gly Met Arg Leu Val 2420 2425 2430 Leu Arg Arg Gly Val Leu Arg Asp Gly Glu Gly Tyr Thr Phe Thr Leu 2435 2440 2445 Thr Val Leu Gly Arg Ser Gly Glu Glu Glu Gly Cys Ala Ser He Arg 2450 2455 2460 Leu Ser Pro Asn Arg Pro Pro Leu Gly Gly Ser Cys Arg Leu Phe Pro 2465 2470 2475 2480 Leu Gly Ala Val His Ala Leu Thr Thr Lys Val His Phe Glu Cys Thr 2485 2490 2495 Gly Trp His Asp Ala Glu Asp Ala Gly Ala Pro Leu Val Tyr Ala Leu 2500 2505 2510 Leu Leu Arg Arg Cys Arg Gin Gly His Cys Glu Glu Phe Cys Val Tyr 2515 2520 2525 Lys Gly Ser Leu Ser Ser Tyr Gly Ala Val Leu Pro Pro Gly Phe Arg 2530 2535 2540 Pro His Phe Glu Val Gly Leu Ala Val Val Val Gin Asp Gin Leu Gly 2545 2550 2555 2560 Ala Ala Val Val Ala Leu Asn Arg Ser Leu Ala He Thr Leu Pro Glu 2565 2570 2575 Pro Asn Gly Ser Ala Thr Gly Leu Thr Val Trp Leu His Gly Leu Thr 2580 2585 2590 Ala Ser Val Leu Pro Gly Leu Leu Arg Gin Ala Asp Pro Gin His Val 2595 2600 2605 He Glu Tyr Ser Leu Ala Leu Val Thr Val Leu Asn Glu Tyr Glu Arg 2610 2615 2620 Ala Leu Asp Val Ala Ala Glu Pro Lys His Glu Arg Gin His Arg Ala 2625 2630 2635 2640 Gin He Arg Lys Asn He Thr Glu Thr Leu Val Ser Leu Arg Val His 2645 2650 2655 Thr Val Asp Asp He Gin Gin He Ala Ala Ala Leu Ala Gin Cys Met 2660 2665 2670 Gly Pro Ser Arg Glu Leu Val Cys Arg Ser Cys Leu Lys Gin Thr Leu 2675 2680 2685 His Lys Leu Glu Ala Met Met Leu He Leu Gin Ala Glu Thr Thr Ala 2690 2695 2700 Gly Thr Val Thr Pro Thr Ala He Gly Asp Ser He Leu Asn He Thr 2705 2710 2715 2720 Gly Asp Leu He His Leu Ala Ser Ser Asp Val Arg Ala Pro Gin Pro 2725 2730 2735 Ser Glu Leu Gly Ala Glu Ser Pro Ser Arg Met Val Ala Ser Gin Ala 2740 2745 2750 Tyr Asn Leu Thr Ser Ala Leu Met Arg He Leu Met Arg Ser Arg Val 2755 2760 2765 Leu Asn Glu Glu Pro Leu Thr Leu Ala Gly Glu Glu He Val Ala Gin 2770 2775 2780 Gly Lys Arg Ser Asp Pro Arg Ser Leu Leu Cys Tyr Gly Gly Ala Pro 2785 2790 2795 2800 Gly Pro Gly Cys His Phe Ser He Pro Glu Ala Phe Ser Gly Ala Leu 2805 2810 2815 Ala Asn Leu Ser Asp Val Val Gin Leu He Phe Leu Val Asp Ser Asn 2820 2825 2830 Pro Phe Pro Phe Gly Tyr He Ser Asn Tyr Thr Val Ser Thr Lys Val 2835 2840 2845 Ala Ser Met Ala Phe Gin Thr Gin Ala Gly Ala Gin He Pro He Glu 2850 2855 2860 Arg Leu Ala Ser Glu Arg Ala He Thr Val Lys Val Pro Asn Asn Ser 2865 2870 2875 2880 Asp Trp Ala Ala Arg Gly His Arg Ser Ser Ala Asn Ser Ala Asn Ser 2885 2890 2895 Val Val Val Gin Pro Gin Ala Ser Val Gly Ala Val Val Thr Leu Asp 2900 2905 2910 Ser Ser Asn Pro Ala Ala Gly Leu His Leu Gin Leu Asn Tyr Thr Leu 2915 2920 2925 Leu Asp Gly His Tyr Leu Ser Glu Glu Pro Glu Pro Tyr Leu Ala Val 2930 2935 2940 Tyr Leu His Ser Glu Pro Arg Pro Asn Glu His Asn Cys Ser Ala Ser 2945 2950 2955 2960 Arg Arg He Arg Pro Glu Ser Leu Gin Gly Ala Asp His Arg Pro Tyr 2965 2970 2975 Thr Phe Phe He Ser Pro Gly Ser Arg Asp Pro Ala Gly Ser Tyr His 2980 2985 2990 Leu Asn Leu Ser Ser His Phe Arg Trp Ser Ala Leu Gin Val Ser Val 2995 3000 3005 Gly Leu Tyr Thr Ser Leu Cys Gin Tyr Phe Ser Glu Glu Asp Met Val 3010 3015 3020 Trp Arg Thr Glu Gly Leu Leu Pro Leu Glu Glu Thr Ser Pro Arg Gin 3025 3030 3035 3040 Ala Val Cys Leu Thr Arg His Leu Thr Ala Phe Gly Ala Ser Leu Phe 3045 3050 3055 Val Pro Pro Ser His Val Arg Phe Val Phe Pro Glu Pro Thr Ala Asp 3060 3065 3070 Val Asn Tyr He Val Met Leu Thr Cys Ala Val Cys Leu Val Thr Tyr 3075 3080 3085 Met Val Met Ala Ala He Leu His Lys Leu Asp Gin Leu Asp Ala Ser 3090 3095 3100 Arg Gly Arg Ala He Pro Phe Cys Gly Gin Arg Gly Arg Phe Lys Tyr 3105 3110 3115 3120 Glu He Leu Val Lys Thr Gly Trp Gly Arg Gly Ser Gly Thr Thr Ala 3125 3130 3135 His Val Gly He Met Leu Tyr Gly Val Asp Ser Arg Ser Gly His Arg 3140 3145 3150 His Leu Asp Gly Asp Arg Ala Phe His Arg Asn Ser Leu Asp He Phe 3155 3160 3165 Arg He Ala Thr Pro His Ser Leu Gly Ser Val Trp Lys He Arg Val 3170 3175 3180 Trp His Asp Asn Lys Gly Leu Ser Pro Ala Trp Phe Leu Gin His Val 3185 3190 3195 3200 He Val Arg Asp Leu Gin Thr Ala Arg Ser Ala Phe Phe Leu Val Asn 3205 3210 3215 Asp Trp Leu Ser Val Glu Thr Glu Ala Asn Gly Gly Leu Val Glu Lys 3220 3225 3230 Glu Val Leu Ala Ala Ser Asp Ala Ala Leu Leu Arg Phe Arg Arg Leu 3235 3240 3245 Leu Val Ala Glu Leu Gin Arg Gly Phe Phe Asp Lys His He Trp Leu 3250 3255 3260 Ser He Trp Asp Arg Pro Pro Arg Ser Arg Phe Thr Arg He Gin Arg 3265 3270 3275 3280 Ala Thr Cys Cys Val Leu Leu He Cys Leu Phe Leu Gly Ala Asn Ala 3285 3290 3295 Val Trp Tyr Gly Ala Val Gly Asp Ser Ala Tyr Ser Thr Gly His Val 3300 3305 3310 ]48 Ser Arg Leu Ser Pro Leu Ser Val Asp Thr Val Ala Val Gly Leu Val 3315 3320 3325 Ser Ser Val Val Val Tyr Pro Val Tyr Leu Ala He Leu Phe Leu Phe 3330 3335 3340 Arg Met Ser Arg Ser Lys Val Ala Gly Ser Pro Ser Pro Thr Pro Ala 3345 3350 3355 3360 Gly Gin Gin Val Leu Asp He Asp Ser Cys Leu Asp Ser Ser Val Leu 3365 3370 3375 Asp Ser Ser Phe Leu Thr Phe Ser Gly Leu His Ala Glu Ala Phe Val 3380 3385 3390 Gly Gin Met Lys Ser Asp Leu Phe Leu Asp Asp Ser Lys Ser Leu Val 3395 3400 3405 Cys Trp Pro Ser Gly Glu Gly Thr Leu Ser Trp Pro Asp Leu Leu Ser 3410 3415 3420 Asp Pro Ser He Val Gly Ser Asn Leu Arg Gin Leu Ala Arg Gly Gin 3425 3430 3435 3440 Ala Gly His Gly Leu Gly Pro Glu Glu Asp Gly Phe Ser Leu Ala Ser 3445 3450 3455 Pro Tyr Ser Pro Ala Lys Ser Phe Ser Ala Ser Asp Glu Asp Leu He 3460 3465 3470 Gin Gin Val Leu Ala Glu Gly Val Ser Ser Pro Ala Pro Thr Gin Asp 3475 3480 3485 Thr His Met Glu Thr Asp Leu Leu Ser Ser Leu Ser Ser Thr Pro Gly 3490 3495 3500 Glu Lys Thr Glu Thr Leu Ala Leu Gin Arg Leu Gly Glu Leu Gly Pro 3505 3510 3515 3520 Pro Ser Pro Gly Leu Asn Trp Glu Gin Pro Gin Ala Ala Arg Leu Ser 3525 3530 3535 Arg Thr Gly Leu Val Glu Gly Leu Arg Lys Arg Leu Leu Pro Ala Trp 3540 3545 3550 Cys Ala Ser Leu Ala His Gly Leu Ser Leu Leu Leu Val Ala Val Ala 3555 3560 3565 Val Ala Val Ser Gly Trp Val Gly Ala Ser Phe Pro Pro Gly Val Ser 3570 3575 3580 Val Ala Trp Leu Leu Ser Ser Ser Ala Ser Phe Leu Ala Ser Phe Leu 3585 3590 3595 3600 Gly Trp Glu Pro Leu Lys Val Leu Leu Glu Ala Leu Tyr Phe Ser Leu 3605 3610 3615 Val Ala Lys Arg Leu His Pro Asp Glu Asp Asp Thr Leu Val Glu Ser 3620 3625 3630 Pro Ala Val Thr Pro Val Ser Ala Arg Val Pro Λrg Val Arg Pro Pro 3635 3640 3645 His Gly Phe Ala Leu Phe Leu Ala Lys Glu Glu Ala Arg Lys Val Lys 3650 3655 3660 Arg Leu His Gly Met Leu Arg Ser Leu Leu Val Tyr Met Leu Phe Leu 3665 3670 3675 3680 Leu Val Thr Leu Leu Ala Ser Tyr Gly Asp Ala Ser Cys His Gly His 3685 3690 3695 Ala Tyr Arg Leu Gin Ser Ala He Lys Gin Glu Leu His Ser Arg Ala 3700 3705 3710 Phe Leu Ala He Thr Arg Ser Glu Glu Leu Trp Pro Trp Met Ala His 3715 3720 3725 Val Leu Leu Pro Tyr Val His Gly Asn Gin Ser Ser Pro Glu Leu Gly 3730 3735 3740 Pro Pro Arg Leu Arg Gin Val Arg Leu Gin Glu Ala Leu Tyr Pro Asp 3745 3750 3755 3760 Pro Pro Gly Pro Arg Val His Thr Cys Ser Ala Ala Gly Gly Phe Ser 3765 3770 3775 Thr Ser Asp Tyr Asp Val Gly Trp Glu Ser Pro His Asn Gly Ser Gly 3780 3785 3790 Thr Trp Ala Tyr Ser Ala Pro Asp Leu Leu Gly Ala Trp Ser Trp Gly 3795 3800 3805 Ser Cys Ala Val Tyr Asp Ser Gly Gly Tyr Val Gin Glu Leu Gly Leu 3810 3815 3820 Ser Leu Glu Glu Ser Arg Asp Arg Leu Arg Phe Leu Gin Leu His Asn 3825 3830 3835 3840 Trp Leu Asp Asn Arg Ser Arg Ala Val Phe Leu Glu Leu Thr Arg Tyr 3845 3850 3855 Ser Pro Ala Val Gly Leu His Ala Ala Val Thr Leu Arg Leu Glu Phe 3860 3865 3870 Pro Ala Ala Gly Arg Ala Leu Ala Ala Leu Ser Val Arg Pro Phe Ala 3875 3880 3885 Leu Arg Arg Leu Ser Ala Gly Leu Ser Leu Pro Leu Leu Thr Ser Val 3890 3895 3900 Cys Leu Leu Leu Phe Ala Val His Phe Ala Val Ala Glu Ala Arg Thr 3905 3910 3915 3920 Trp His Arg Glu Gly Arg Trp Arg Val Leu Arg Leu Gly Ala Trp Ala 3925 3930 3935 Arg Trp Leu Leu Val Ala Leu Thr Ala Ala Thr Ala Leu Val Arg Leu 3940 3945 3950 Ala Gin Leu Gly Ala Ala Asp Arg Gin Trp Thr Arg Phe Val Arg Gly 3955 3960 3965 Arg Pro Arg Arg Phe Thr Ser Phe Asp Gin Val Ala Gin Leu Ser Ser 3970 3975 3980 Ala Ala Arg Gly Leu Ala Ala Ser Leu Leu Phe Leu Leu Leu Val Lys 3985 3990 3995 4000 Ala Ala Gin Gin Leu Arg Phe Val Arg Gin Trp Ser Val Phe Gly Lys 4005 4010 4015 Thr Leu Cys Arg Ala Leu Pro Glu Leu Leu Gly Val Thr Leu Gly Leu 4020 4025 4030 Val Val Leu Gly Val Ala Tyr Ala Gin Leu Ala He Leu Leu Val Ser 4035 4040 4045 Ser Cys Val Asp Ser Leu Trp Ser Val Ala Gin Ala Leu Leu Val Leu 4050 4055 4060 Cys Pro Gly Thr Gly Leu Ser Thr Leu Cys Pro Ala Glu Ser Trp His 4065 4070 4075 4080 Leu Ser Pro Leu Leu Cys Val Gly Leu Trp Ala Leu Arg Leu Trp Gly 4085 4090 4095 Ala Leu Arg Leu Gly Ala Val He Leu Arg Trp Arg Tyr His Ala Leu 4100 4105 4110 Arg Gly Glu Leu Tyr Arg Pro Ala Trp Glu Pro Gin Asp Tyr Glu Met 4115 4120 4125 Val Glu Leu Phe Leu Arg Arg Leu Arg Leu Trp Met Gly Leu Ser Lys 4130 4135 4140 Val Lys Glu Phe Arg His Lys Val Arg Phe Glu Gly Met Glu Pro Leu 4145 4150 4155 4160 Pro Ser Arg Ser Ser Arg Gly Ser Lys Val Ser Pro Asp Val Pro Pro 4165 4170 4175 Pro Ser Ala Gly Ser Asp Ala Ser His Pro Ser Thr Ser Ser Ser Gin 4180 4185 4190 Leu Asp Gly Leu Ser Val Ser Leu Gly Arg Leu Gly Thr Arg Cys Glu 4195 4200 4205 Pro Glu Pro Ser Arg Leu Gin Ala Val Phe Glu Ala Leu Leu Thr Gin 4210 4215 4220 Phe Asp Arg Leu Asn Gin Ala Thr Glu Asp Val Tyr Gin Leu Glu Gin 4225 4230 4235 4240 Gin Leu His Ser Leu Gin Gly Arg Arg Ser Ser Arg Ala Pro Ala Gly 4245 4250 4255 Ser Ser Arg Gly Pro Ser Pro Gly Leu Arg Pro Ala Leu Pro Ser Arg 4260 4265 4270 Leu Ala Arg Ala Ser Arg Gly Val Asp Leu Ala Thr Gly Pro Ser Arg 4275 4280 4285 Thr Pro Leu Arg Ala Lys Asn Lys Val His Pro Ser Ser Thr 4290 4295 4300 (2) INFORMATION FOR SEQ ID NO: 6: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6: CACGACCTGT CCCAGGCAT 19 (2) INFORMATION FOR SEQ ID NO:7: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7: CTGGCGGGCG AGGAGAT 17 (2) INFORMATION FOR SEQ ID NO: 8: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 8: CTTTGACAAG CACATCT 17 (2) INFORMATION FOR SEQ ID NO:9: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (11) MOLECULE TYPE: DNA (genomic) (xi ) SEQUENCE DESCRIPTION: SEQ ID NO:9. CAACTGGCTG GACAACA 17 (2) INFORMATION FOR SEQ ID NO: 10: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (n) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10: AGGACCTGTC CAGGCATC 18 (2) INFORMATION FOR SEQ ID NO:11: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 11 CTGCACTGAC CTCACGCATG T 21 (2) INFORMATION FOR SEQ ID NO: 12: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (n) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12: ACGTTGGGCT CCTGGCGAAC C 21 (2) INFORMATION FOR SEQ ID NO:13: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH. 25 base pairs (B) TYPE nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13: AGGTCAACGT GGGCCTCCAA GTAGT 25 (2) INFORMATION FOR SEQ ID NO:14: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14: GCGCTTTGCA GACGGTAGGC G 21 (2) INFORMATION FOR SEQ ID NO:15: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15: AGCGCAACTA CTTGGAGGCC C 21 (2) INFORMATION FOR SEQ ID NO:16: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 16: GCCAAAGGGA AAGGGATTGG A 21 (2) INFORMATION FOR SEQ ID NO:17: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 17: Cys Ser Arg Thr Pro Leu Arg Ala Lys Asn Lys Val His Pro Ser Ser 1 5 10 15 Thr (2) INFORMATION FOR SEQ ID NO:18: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 160 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18: GGAAACAGGT TTGGAGAGGT GACACGACCT GTCCCAGGCA TCACAGCCAG GACAGGACCT 60 GTCCAGGCAT CACAGCCGGG ATGTGCATAG CAGGGGTTTG GAACTATGAG GTGCCCAGGA 120 CCCAGGGTTG GATTGAAAAG GGCGCAGGGG ACTAAGATAA 160 (2) INFORMATION FOR SEQ ID NO:19: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 131 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 19: GGAAACAGGT TTGGAGAGGT GACACGACCT GTCCCAGGCA TCACAGCCGG GATGTGCATA 60 GCAGGGGTTT GGAACTATGA GGTGCCCAGG ACCCAGGGTT GGATTGAAAA GGGCGCAGGG 120 GACTAAGATA A 131 (2) INFORMATION FOR SEQ ID NO:20: (i) SEQUENCE CHARACTERISTICS: (Λ) LENGTH: 60 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS. single (D) TOPOLOGY- linear (ii) MOLECULE TYPE: cDNA (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..60 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:20: CGC CCG CGC CGC TTC ACT AGC TTC GAC CAG GTG GCG CAC GTG AGC TCC 48 Arg Pro Arg Arg Phe Thr Ser Phe Asp Gin Val Ala His Val Ser Ser 1 5 10 15 GCA GCC CGT GGC 60 Ala Ala Arg Gly 20 (2) INFORMATION FOR SEQ ID NO:21: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 amino acids (B) TYPE: ammo acid (D) TOPOLOGY- linear (n) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21: Arg Pro Arg Arg Phe Thr Ser Phe Asp Gin Val Ala His Val Ser Ser 1 5 10 15 Ala Ala Arg Gly 20 (2) INFORMATION FOR SEQ ID NO:22: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 60 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ll) MOLECULE TYPE: DNA (genomic) (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..60 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22: CGC CCG CGC CGC TTC ACT AGC TTC GAC CAG GTG GCG CAG CTG AGC TCC 48 Arg Pro Arg Arg Phe Thr Ser Phe Asp Gin Val Ala Gin Leu Ser Ser 1 5 10 15 GCA GCC CGT GGC 60 Ala Ala Arg Gly 20 (2) INFORMATION FOR SEQ ID NO:23: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:23: Arg Pro Arg Arg Phe Thr Ser Phe Asp Gin Val Ala Gin Leu Ser Ser 1 5 10 15 Ala Ala Arg Gly 20 (2) INFORMATION FOR SEQ ID NO:24: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 60 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..60 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:24: GCT GCC CAG CAC GTA CGC TTC GTG CGC CAG TGG TCC GTC TTT GGC AAG 48 Ala Ala Gin His Val Arg Phe Val Arg Gin Trp Ser Val Phe Gly Lys 1 5 10 15 ACA TTA TGC CGA 60 Thr Leu Cys Arg 20 (2) INFORMATION FOR SEQ ID NO:25: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:25: Ala Ala Gin His Val Arg Phe Val Arg Gin Trp Ser Val Phe Gly Lys 1 5 10 15 Thr Leu Cys Arg 20 (2 ) INFORMATION FOR SEQ JD NO:26: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 60 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..60 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26: GCT GCC CAG CAG CTA CGC TTC GTG CGC CAG TGG TCC GTC TTT GGC AAG 48 Ala Ala Gin Gin Leu Arg Phe Val Arg Gin Trp Ser Val Phe Gly Lys 1 5 10 15 ACA TTA TGC CGA 60 Thr Leu Cys Arg 20 (2) INFORMATION FOR SEQ ID NO:27: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:27: Ala Ala Gin Gin Leu Arg Phe Val Arg Gin Trp Ser Val Phe Gly Lys 1 5 10 15 Thr Leu Cys Arg 20 (2) INFORMATION FOR SEQ ID NO:28: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 81 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..81 15$ (xi) SEQUENCE DESCRIPTION: SEQ ID NO:28: CTG GCC ACT GGC CCC AGC AGG ACA CCT TCG GGC CAA GAA CAA GGT CCA 48 Leu Ala Thr Gly Pro Ser Arg Thr Pro Ser Gly Gin Glu Gin Gly Pro 1 5 10 15 CCC CAG CAG CAC TTA GTC CTC CTT CCT GGC GGG 81 Pro Gin Gin His Leu Val Leu Leu Pro Gly Gly 20 25 (2) INFORMATION FOR SEQ ID NO:29: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:29: Leu Ala Thr Gly Pro Ser Arg Thr Pro Ser Gly Gin Glu Gin Gly Pro 1 5 10 15 Pro Gin Gin His Leu Val Leu Leu Pro Gly Gly 20 25 (2) INFORMATION FOR SEQ ID NO: 30: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 81 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..64 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:30: CTG GCC ACT GGC CCC AGC AGG ACA CCC CTT CGG GCC AAG AAC AAG GTC 48 Leu Ala Thr Gly Pro Ser Arg Thr Pro Leu Arg Ala Lys Asn Lys Val 1 5 10 15 CAC CCC AGC AGC ACT T AGTCCTCCTT CCTGGCG 81 His Pro Ser Ser Thr 20 (2) INFORMATION FOR SEQ ID NO:31: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION. SEQ ID NO:31: Leu Ala Thr Gly Pro Ser Arg Thr Pro Leu Arg Ala Lys Asn Lys Val 1 5 10 15 His Pro Ser Ser Thr 20 (2) INFORMATION FOR SEQ ID NO:32: (i) SEQUENCE CHARACTERISTICS. (A) LENGTH: 34 ammo acids (D) TOPOLOGY: linear (il) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:32: Ala Leu Thr His Gly His Ser Leu Leu Arg Asp Val Ser His Asn Leu 1 5 10 15 Leu Arg Ala Leu Asp Val Gly Leu Leu Ala Asn Leu Ser Ala Leu Ala 20 25 30 Glu Leu (2) INFORMATION FOR SEQ ID NO:33: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:33: Leu His Gly Leu Lys Ala Leu Gly His Leu Asp Leu Ser Gly Asn Arg 1 5 10 15 Leu Arg Lys Leu Pro Pro Gly Leu Leu Ala Asn Phe Thr Leu Leu Arg 20 25 30 Thr Leu (2) INFORMATION FOR SEQ ID NO:34: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 ammo acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:34: Pro Ala Leu Pro Ala Arg Thr Arg His Leu Leu Leu Ala Asn Asn Ser 1 5 10 15 Leu Gin Ser Val Pro Pro Gly Ala Phe Asp His Leu Pro Gin Leu Gin 20 25 30 Thr Leu (2) INFORMATION FOR SEQ ID NO:35: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 35: Gly Gin Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg 1 5 10 15 Leu Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gin 20 25 30 Glu Leu (2) INFORMATION FOR SEQ ID NO: 36: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:36: Thr Ala Phe Pro Val Asp Thr Thr Glu Leu Val Leu Thr Gly Asn Asn 1 5 10 15 Leu Thr Ala Leu Pro Pro Gly Leu Leu Asp Ala Leu Pro Ala Leu Arg 20 25 30 Thr Ala (2) INFORMATION FOR SEQ ID NO:37: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:37: Leu Glu His Gin Val Asn Leu Leu Ser Leu Asp Leu Ser Asn Asn Ala 1 5 10 15 Leu Thr His Leu Pro Asp Ser Leu Phe Ala His Thr Thr Asn Leu Thr 20 25 30 Asp Leu (2) INFORMATION FOR SEQ ID NO:38: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:38: He Arg His Leu Arg Ser Leu Thr Arg Leu Asp Leu Ser Asn Asn Gin 1 5 10 15 He Thr He Leu Ser Asn Tyr Thr Phe Ala Asn Leu Thr Lys Leu Ser 20 25 30 Thr Leu (2) INFORMATION FOR SEQ ID NO:39: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:39: Phe Gly Asn Met Pro His Leu Gin Trp Leu Asp Leu Ser Tyr Asn Trp 1 5 10 15 He His Glu Leu Asp Phe Asp Ala Phe Lys Asn Thr Lys Gin Leu Gin 20 25 30 Leu Val (2) INFORMATION FOR SEQ ID NO:40: ( l ) SEQUENCE CHARACTERISTICS. (A) LENGTH: 17 ammo acids (B) TYPE: amino acid (D) TOPOLOGY linear (11) MOLECULE TYPE- peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:40. Leu Asp Leu Ser Asn Leu Thr Leu Pro Gly Leu Leu Ala Leu Leu Thr 1 5 10 15 Leu (2) INFORMATION FOR SEQ ID NO:41: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:41: Gly Pro Gin His Leu Pro Leu Pro Cys Arg Asn Leu Ser Gly Asn Pro 1 5 10 15 Phe Glu Cys Asp Cys Gly Leu Ala Trp Leu Pro Arg Trp Ala Glu Glu 20 25 30 (2) INFORMATION FOR SEQ ID NO:42: (l) SEQUENCE CHARACTERISTICS. (A) LENGTH: 32 ammo acids (D) TOPOLOGY: linear (n) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:42: Gin Pro Asn Trp Asp Met Arg Asp Gly Phe Asp He Ser Gly Asn Pro 1 5 10 15 Trp He Cys Asp Gin Asn Leu Ser Asp Leu Tyr Arg Trp Leu Gin Ala 20 25 30 (2) INFORMATION FOR SEQ ID NO:43: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 ammo acids (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:43: Thr Val Gin Gly Leu Ser Leu Gin Glu Leu Val Leu Ser Gly Asn Pro 1 5 10 15 Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gin Arg Trp Glu Glu Glu 20 25 30 (2) INFORMATION FOR SEQ ID NO:44: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44: Phe Asp His Leu Pro Gin Leu Gin Thr Leu Asp Val Thr Gin Asn Pro 1 5 10 15 Trp His Cys Asp Cys Ser Leu Thr Tyr Leu Arg Leu Trp Leu Glu Asp 20 25 30 (2) INFORMATION FOR SEQ ID NO:45: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:45: Phe Phe Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro 1 5 10 15 Trp Leu Cys Asn Cys Glu He Leu Tyr Phe Arg Arg Trp Leu Gin Asp 20 25 30 (2) INFORMATION FOR SEQ ID NO:46: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46: Leu Asp Ala Leu Pro Ala Leu Arg Thr Ala His Leu Gly Ala Asn Pro 1 5 10 15 Trp Arg Cys Asp Cys Arg Leu Val Pro Leu Arg Ala Trp Leu Ala Gly 20 25 30 (2) INFORMATION FOR SEQ ID NO:47: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:47: Leu Asn Arg Thr Met Lys Trp Arg Ser Val Lys Leu Ser Gly Asn Pro 1 5 10 15 Trp Met Cys Asp Cys Thr Ala Lys Pro Leu Leu Leu Phe Thr Gin Asp 20 25 30 (2) INFORMATION FOR SEQ ID NO:48: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:48: Phe Glu Asp Leu Lys Ser Leu Thr His He Ala Leu Gly Ser Asn Pro 1 5 10 15 Leu Tyr Cys Asp Cys Gly Leu Lys Trp Phe Ser Asp Trp He Lys Leu 20 25 30 (2) INFORMATION FOR SEQ ID NO:49: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:49: Leu Leu Ser Gly Asn Pro Trp Cys Asp Cys Leu Trp Leu Arg Trp 1 5 10 15 (2) INFORMATION FOR SEQ ID NO:50: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:50: Thr Ala Thr Arg Trp Asp Phe Gly Asp Gly Ser Ala Glu Val Asp Ala 1 5 10 15 Ala Gly Pro Ala Ala Ser His Arg Tyr Val Leu Pro Gly Arg Tyr His 20 25 30 Val Thr Ala 35 (2) INFORMATION FOR SEQ ID NO:51: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:51: Val Leu Tyr Thr Trp Asp Phe Gly Asp Gly Ser Pro Val Leu Thr Gin 1 5 10 15 Ser Gin Pro Ala Ala Asn His Thr Tyr Ala Ser Arg Gly Thr Tyr His 20 25 30 Val Arg Leu 35 (2) INFORMATION FOR SEQ ID NO:52: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 52 : Val Ala Tyr His Trp Asp Phe Gly Asp Gly Ser Pro Gly Gin Asp Thr 1 5 10 15 Asp Glu Pro Arg Ala Glu His Ser Tyr Leu Arg Pro Gly Asp Tyr Arg 20 25 30 Val Gin Val 35 (2) INFORMATION FOR SEQ ID NO: 53: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 53: Leu Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu He Ser 1 5 10 15 Arg Ala Pro Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr 20 25 30 Ala Gin Val 35 (2) INFORMATION FOR SEQ ID NO:54: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:54: Leu Ser Tyr Thr Trp Asp Phe Gly Asp Ser Thr Gly Thr Leu He Ser 1 5 10 15 Arg Ala Leu Thr Val Thr His Thr Tyr Leu Glu Ser Gly Pro Val Thr 20 25 30 Ala Gin Val 35 (2) INFORMATION FOR SEQ ID NO:55: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (13 ) MOLECULE TYPE, peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:55: Tyr Thr Trp Asp Phe Gly Asp Gly Ser Leu Pro Ala His Thr Tyr Leu 1 5 10 15 Pro Gly Tyr Val Gin Val 20 (2) INFORMATION FOR SEQ ID NO: 56: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (n) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:56: ATCTCCTCGC CCGCCAG 17 (2) INFORMATION FOR SEQ ID NO: 57: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE- nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (il) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:57: AGATGTGCTT GTCAAAG 17 (2) INFORMATION FOR SEQ ID NO:58: (l) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (n) MOLECULE TYPE DNA (genomic) (xi) SEQUENCE DESCRIPTION SEQ ID NO.58: TGTTGTCCAG CCAGTTG 17

Claims: What is claimed is: 1. Isolated nucleic acid encoding human PKDl polypeptide. 2. Isolated nucleic acid according to claim 1, wherein said nucleic acid is DNA comprising the sequence set forth in SEQ ID NO:2. 3. Isolated nucleic acid according to claim 1, wherein said nucleic acid is RNA. 4. Isolated nucleic acid according to claim 1, wherein said nucleic acid is cDNA comprising the sequence set forth in SEQ ID NO:4. 5. Isolated nucleic acid that hybridizes under stringent conditions to the nucleic acid of claim 1. 6. Isolated nucleic acid according to claim 5, comprising the sequence set forth in SEQ ID NO:3. 7. Isolated polypeptide encoded by the nucleic acid of claim 1. 8. Isolated polypeptide according to claim 7 comprising the amino acid sequence set forth in SEQ ID NO:5. 9. A vector comprising the isolated nucleic acid of claim 1. 10. A vector according to claim 9 further comprising a transcriptional regulatory element operably linked to said nucleic acid, said element having the ability to direct the expression of genes of prokaryotic or eukaryotic cells and their viruses or combinations thereof. 11. A host cell comprising the vector of claim 9. 12. A method for producing PKDl protein, which comprises: (a) culturing the host cell of claim 11 in a medium and under conditions suitable for expression of said protein, and (b) isolating said expressed protein. 13. Isolated human PKDl gene, comprising the DNA sequence set forth in SEQ ID NO:2 having modifications selected from the group consisitng of: transitions, transversions, deletions, and insertions. 14. The gene of claim 13, comprising a DNA sequence * whose presence in one or more copies in the genome of a subject is associated with adult-onset polycystic kidney disease in said subject. 15. A recombinant vector comprising the DNA sequence of claim 13. 16. The vector of claim 15 further comprising a transcriptional regulatory element operably linked to said DNA sequence, said element having the ability to direct the expression of genes of prokaryotic or eukaryotic cells and their viruses or combinations hereof . 17. A host cell comprising the vector of claim 15. 18. A method for producing mutant PKDl protein, which comprises: (a) culturing the host cell of claim 17 in a medium and under conditions suitable for expression of said protein, and (b) isolating said expressed protein. 19. An isolated nucleic acid comprising: 5'-AGGACCTGTCCAGGCATC-3' (SEQ ID NO: 10) . 20. An isolated nucleic acid comprising: 5 ' -GCGCTTTGCAGACGGTAGGCG-3 ' (SEQ ID NO: 14) . 21. An isolated nucleic acid comprising: 5 ' -AGGTCAACGTGGGCCTCCAAGTAGT-3 ' (SEQ ID NO:13) . 22. An isolated nucleic acid comprising: 5 ' -AGCGCAACTACTTGGAGGCCC-3 ' (SEQ ID NO:15) . 23. A diagnostic method for screening human subjects to identify PKDl carriers, which comprises the steps of: (1) obtaining a sample of biological material from said subject; and (2) assaying for the presence of mutant PKDl genes or their protein products in said biological material. 24. The method of claim 23 wherein said biological material comprises nucleic acid, and said assaying comprises : (a) selectively amplifying the authentic PKDl gene, or fragments thereof, from said biological material, and (b) detecting the presence of normal and mutant PKDl genes using an analytical method selected fromthe group consisting of: restriction enzyme digestion, direct DNA sequencing, hybridization with sequence-specific oligonucleotides, single-stranded conformational polymorphism analysis, denaturating gradient gel electrophoresis (DDGE) , two-dimensional gel electrophoresis, and combinations thereof. 25. The method of claim 24 wherein said amplifying is performed in the presence of at least one oligonucleotide selected from the group consisting of 5' -AGGACCTGTCCAGGCATC-3' (SEQ ID NO:10) , 5'-GCGCTTTGCAGACGGTAGGCG-3' (SEQ ID NO: 14) , 5'-AGGTCAACGTGGGCCTCCAAGTAGT-3' (SEQ ID NO:13), and 5 ' -AGCGCAACTACTTGGAGGCCC-3 ' (SEQ ID NO:15) 26. The method of claim 23, wherein said assaying step comprises an immunoassay employing an antibody specific for said PKDl gene product. 27. An isolated antibody directed against a peptide comprising the sequence (C)SRTPLRAKNKVHPSST (SEQ ID NO:15), or immunogenic fragments thereof. 28. The antibody of claim 27 immunoreactive with a polypeptide encoded by the gene sequence set forth in SEQ ID NO:2. 29. An isolated antibody immunoreactive with a polypeptide encoded by the sequence set forth in SEQ ID NO:2. 30. An isolated antibody immunoreactive with a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:5. 31. A method for treating a disease condition having the characterisitics of APKD, which comprises administering to cells having defective PKDl gene function a normal human PKDl gene or fragments thereof, wherein said administration results in expression of therapeutically effective amounts of normal PKDl protein or fragments thereof. 32. The method claim 31, wherein said normal human PKDl gene comprises the DNA sequence of SEQ ID NO:2. 33. The method of claim 31, wherein said normal human PKDl gene comprises the cDNA sequence of SEQ ID NO:4. 34. A method for treating a disease condition having the characterization of APKD, which comprises administering to cells having defective PKDl gene function therapeutically effective amounts of a normal PKDl protein or fragments thereof. 35. The method of claim 34, wherein said PKDl protein is encoded by the DNA sequence set forth in SEQ ID NO:2. 36. The method of claim 34, wherein said PKDl protein is encoded by the cDNA sequence set forth in SEQ ID NO:4. 37. The method of claim 35, further comprising administering a polypeptide having an amino acid sequence set forth in SEQ ID NO:5. 38. A composition for treating a disease condition having the characteristics of APKD, said composition comprising an isolated human PKDl gene having the DNA sequence of SEQ ID NO:2, or fragments thereof, and a pharmaceutically acceptable carrier or diluent. 39. The composition of claim 38 comprising a vector into which said PKDl gene is incorporated. 40. The composition of claim 38, further comprising an isolated human PKDl gene having the DNA sequence of SEQ ID NO:4 for fragments thereof. 41. A composition for treating a disease condition having the characteristics of APKD, said composition comprising a normal PKDl protein encoded by the DNA sequence of SEQ ID NO:2, or fragments thereof, and a pharmaceutically acceptable carrier or diluent. 42. The composition of claim 41 further comprising a polypeptide encoded by the DNA sequence of SEQ ID NO:4, or fragments thereof. 43. A unicellular or multicellular organism whose genome comprises a recombinant PKDl gene or fragments thereof. 44. The organism of claim 43 wherein said PKDl gene has the DNA sequence of SEQ ID NO:2 or fragments thereof. 45. The organism of claim 43 wherein said PKDl gene has the sequence of SEQ ID NO:4 or fragments thereof.

Inventors: BURN TIMOTHY, CONNORS TIMOTHY, DACKOWSKI WILLIAM, GERMINO GREGORY, KLINGER KATHERINE, QIAN FENG, BURN, TIMOTHY, CONNORS, TIMOTHY, DACKOWSKI, WILLIAM, GERMINO, GREGORY, KLINGER, KATHERINE, QIAN, FENG
Applicants: GENZYME CORP, GENZYME CORPORATION
Application year: 1997
Main classification: C12N15
IPC codes: A01K67, A61K38, A61P13, C07K14, C07K16, C12N1, C12N5, C12N15, C12P21, C12Q1, G01N33