ARYLAMINO FUSED PYRIDINES AND PYRIMIDINES

Abstract: Corticotropin releasing factor (CRF) antagonists of formula (I) or formula (II): and their use in treating anxiety, depression, and other psychiatric and neurological disorders.

Description: TITLE ARYLAMINO FUSED PYRIDINES AND PYRIMIDINES FIELD OF THE INVENTION This invention relates to novel compounds and pharmaceutical compositions, and to methods of using same in the treatment of psychiatric disorders and neurological diseases including major depression, anxiety-related disorders, pos -traumatic stress disorder, supranuclear palsy and feeding disorders. BACKGROUND OF THE INVENTION Corticotropin releasing factor (herein referred to as CRF) , a 41 amino acid peptide, is the primary physiological regulator of proopiomelanocortin(POMC) -derived peptide secretion from the anterior pituitary gland [J. Rivier et al., Proc Nat . Acad. Sci . (USA) 80:4851 (1983); W. Vale et al. , Science 213:1394 (1981)]. In addition to its endocrine role at the pituitary gland, immunohistochemical localization of CRF has demonstrated that the hormone has a broad extrahypothalamic distribution in the central nervous system and produces a wide spectrum of autonomic, electrophysiological and behavioral effects consistent with a neurotransmitter or neuromodulator role in brain [W. Vale et al., Rec. Prog. Horm. Res . 39:245 (1983); G.F. Koob, Persp. Behav. Med. 2:39 (1985); E.B. De Souza et al., J. Neurosci . 5:3189 (1985)]. There is also evidence that CRF plays a significant role in integrating the response of the immune system to physiological, psychological, and im unological stressors [J.E. Blalock, Physiological Reviews 69:1 (1989); J.E. Morley, Li fe Sci . 41:527 (1987)]. Clinical data provide evidence that CRF has a role in psychiatric disorders and neurological diseases including depression, anxiety-related disorders and feeding disorders. A role for CRF has also been postulated in the etiology and pathophysiology of Alzheimer's disease, Parkinson's disease, Huntington's disease, progressive supranuclear palsy and amyotrophic lateral sclerosis as they relate to the dysfunction of CRF neurons in the central nervous system [for review see E.B. De Souza, Hosp. Practice 23:59 (1988)]. In affective disorder, or major depression, the concentration of CRF is significantly increased in the cerebral spinal fluid (CSF) of drug-free individuals [C.B. Ne eroff et al., Science 226:1342 (1984); CM. Banki et al. , Am. J. Psychiatry 144:873 (1987); R.D. France et al., Biol . Psychiatry 28:86 (1988); M. Arato et al., Biol Psychiatry 25:355 (1989)]. Furthermore, the density of CRF receptors is significantly decreased in the frontal cortex of suicide victims, consistent with a hypersecretion of CRF [C.B. Nemeroff et al.. Arch. Gen . Psychiatry 45:577 (1988)]. In addition, there is a blunted adrenocorticotropin (ACTH) response to CRF (i.v. administered) observed in depressed patients [P.W. Gold et al., Am J. Psychiatry 141:619 (1984); F. Holsboer et al., Psychoneuroendocrinology 9:147 (1984); P.W. Gold et al., New Eng. J. Med. 314:1129 (1986)]. Preclinical studies in rats and non-human primates provide additional support for the hypothesis that hypersecretion of CRF may be involved in the symptoms seen in human depression [R.M. Sapolsky, Arch. Gen . Psychiatry 46:1047 (1989)]. There is preliminary evidence that tricyclic antidepressants can alter CRF levels and thus modulate the numbers of CRF receptors in brain [Grigoriadis et al., Neuropsychopharmacology 2:53 (1989) ] . There has also been a role postulated for CRF in the etiology of anxiety-related disorders. CRF produces anxiogenic effects in animals and interactions between benzodiazepine / non- benzodiazepine anxiolytics and CRF have been demonstrated in a variety of behavioral anxiety models [D.R. Britton et al., Life Sci . 31:363 (1982); C.W. Berridge and A.J. Dunn Regul . Peptides 16:83 (1986)]. Preliminary studies using the putative CRF receptor antagonist a-helical ovine CRF (9-41) in a variety of behavioral paradigms demonstrate that the antagonist produces "anxiolytic-like" effects that are qualitatively similar to the benzodiazepines [C.W. Berridge and A.J. Dunn Horm. Behav. 21:393 (1987) , Brain Research Reviews 15:71 (1990)] . Neurochemical, endocrine and receptor binding studies have all demonstrated interactions between CRF and benzodiazepine anxiolytics providing further evidence for the involvement of CRF in these disorders. Chlordiazepoxide attenuates the "anxiogenic" effects of CRF in both the conflict test [K.T. Britton et al., Psychopharmacology 86:170 (1985); K.T. Britton et al., Psychopharmacology 94:306 (1988)] and in the acoustic startle test [N.R. Swerdlow et al., Psychopharmacology 88:147 (1986)] in rats. The benzodiazepine receptor antagonist (Rol5-1788) , which was without behavioral activity alone in the operant conflict test, reversed the effects of CRF in a dose- dependent manner while the benzodiazepine inverse agonist (FG7142) enhanced the actions of CRF [K.T. Britton et al., Psychopharmacology 94:306 (1988)]. The mechanisms and sites of action through which the standard anxiolytics and antidepressants produce their therapeutic effects remain to be elucidated. It has been hypothesized however, that they are involved in the suppression of the CRF hypersecretion that is observed, in these disorders. Of particular interest is that preliminary studies examining the effects of a CRF receptor antagonist (a -helical CRF9-41) in a variety of behavioral paradigms have demonstrated that the CRF antagonist produces "anxiolytic-like" effects qualitatively similar to the benzodiazepines [for review see G.F. Koob and K.T. Britton, In: Corticotropin-Releasing Factor: Basic and Clinical Studi es of a Neuropeptide, E.B. De Souza and C.B. Nemeroff eds., CRC Press p221 (1990)] . DuPont Merck PCT application US94/11050 describes corticotropin releasing factor antagonist compounds of the formula: and their use to treat psychiatric disorders and neurological diseases. Included in the description are fused pyridines and pyrimidines of the formula: where: V is CR la or N; Z is CR 2 or N; A is CR 30 or N; and D is CR 28 or N. Pfizer WO 95/33750 describes corticotropin releasing factor- antagonist compounds useful in the treatment of CNS and stress disorders. The description includes compounds of the formulae: where A is CR7 or N; B is -NR 1 R 2 ; Ri is substituted or unsubstituted alkyl; R 2 is substituted or unsubstituted alkyl, aryl or heteroaryl; R 3 is methyl, halo, cyano, methoxy, etc.; R 4 is H, substituted or unsubstituted alkyl, halo, a ino, nitro, etc.; R 5 is substituted or unsubstituted aryl or heteroaryl; R δ is H or substituted or unsubstituted alkyl; R 7 is H, methyl, halo, cyano, etc.; Ri 6 and R 1 7 taken together form an oxo (=0) group; and G is =0, =S, =NH, =NCH 3 , hydrogen, methyl, methoxy, etc. Pfizer WO 95/33750 also describes intermediates of the formula: where A can be N, D can be OH, R 4 can be nitro, R 19 is methyl or ethyl, Z can be NH or N(CH 3 ), and R 5 is substituted phenyl or substituted pyridyl, each substituted with 2 or 3 substituents selected from C1-C4 alkyl, chloro and bromo. Pfizer WO 95/34563 describes corticotropin releasing factor antagonist compounds, including compounds of the formula: where A, B and the R groups have definitions similar to those in WO 95/33750. Pfizer WO 95/33727 describes corticotropin releasing factor antagonist compounds of the formula: where A is CH2 and Z can be a heteroaryl moiety. Ganguly et al., U.S. Patent 4,076,711 describes triazolo[4, 5-d]pyrimidines of the formula: where X is halo, -NRjR or alkoxy, with Rl and R each being H or alkyl; Y is alkyl, cycloalkyl, hydroxycycloalkyl, phenyl, bicycloalkyl or phenylalkyl or bicycloalkylalkyl; and Q is H or Y. The patent states that the compounds are useful in the treatment of psoriasis. Tanji et al., Chem. Pharm. Bull. 39(11)3037- 3040(1991), describes triazolo[4, 5-d]pyrimidines of the formula: where halo is I, Br or Cl, Ph is phenyl and Me is methyl. No utility for the compounds is described. Settimo et al., II Farmaco, Ed. Sc , 35 (4), 308-323 (1980) describes 8-azaadenines (triazolo[4, 5-d] pyrimidines) of the formula: where Rl is H or benzyl and R2 is p-methylphenyl. Biagi et al., II Farmaco, 49 (3), 183-186 (1994), describes N{6) -substituted 2-n-butyl-9-benzyl-i azaadenines of the formula: where R 2 can be alkyl, phenyl, or benzyl. The paper states that the compounds have affinity for adenosine receptors. Thompson et al., J. Med. Chem., 1991, 34, 2877- 2882, describes N 6 , 9-disubstituted adenines of the formula: Hor where Ph is phenyl or (when C-2 is unsubstituted) 2- fluorophenyl. The paper states that the compounds have selective affinity for the Ai adenosine receptor. Kelley et al., J. Med. Chem. 1990, 31, 606-612, describes the compound where R 6 is NHCeHs and R 9 is CH 2 C6H5, and reports that the compound was inactive when tested for anticonvulsant activity. The paper reports that various 6- (alkyla ino)-9-benzyl-9H-purine analogs of the above compound exhibited anticonvulsant activity. Kelley et al., J. Med. Chem. 1990, 33, 1360-1363, describes 6-anilino-9-benzyl-2-choro-9H-purines of the formula: where Bz is benzyl or (when R 4 is H) p-methylbenzyl and R 4 is H or alkyl, alkoxy, halo, cyano, nitro, etc. Tests of the compounds for antirhinoviral activity are reported. Kelley et al., J. Heterocyclic Chem., 28, 1099 (1991), describes 6-substituted-9- (3-formamidobenzyi; 9H-purines of the formula: where Rl is NH2 or NHCHO. The compound where Rl is NHCHO was tested for benzodiazepine receptor binding and was inactive, although various analogs were active. Khairy et al . , J. Heterocyclic Chem., 22, 853 (1985) , describes synthesis of certain 9-aryl-9H-purin- 6-amines of the formula: where the R groups are H, methyl, ethyl, isopropyl, chloro or fluoro. SUMMARY OF THE INVENTION This invention is a class of novel compounds which are CRF receptor antagonists and which can be represented by formula I or formula II: II or a pharmaceutically acceptable salt or pro-drug form thereof, wherein: X is N or CR 1 ; Y is N or CR 2 ; Z is NR 3 , 0, or S(0) n ; G is 0 or S; Ar is phenyl, naphthyl, pyridyl, pyrimidinyl, triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzthiazolyl, isoxazolyl or pyrazolyl, each optionally substituted with 1 to 5 R^ groups,- R 1 is independently at each occurrence H, C]_- C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, halo, CN, C1-C4 haloalkyl, -NR 9 R 10 , NR 9 COR 10 , -OR 11 , SH or -S(0) n R 12 ; R 2 is H, C1-C4 alkyl, C1-C6 cycloalkyl, halo, CN, -NR 6 R 7 , NR 9 COR 10 , C1-C4 haloalkyl, -OR 7 , SH or -S ( 0 ) nR 12 ; R 3 is H, C1-C10 alkyl, C2-C10 alkenyl, C2- C10 alkynyl, C3-C8 cycloalkyl or C4- C12 cycloalkylalkyl each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, halo, C1-C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 )2, -NR 8 C0NR 6 R 7 , -NR 8 Cθ2R 13 , -NR 6 R 7 , -CONR 6 R 7 , aryl, heteroaryl and heterocyclyl, where the aryl, heteroaryl or heterocyclyl is optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, halo, C1-C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 -COR 7 , -C02R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , and -CONR 6 R 7 ; R 4 is H, C1-C4 alkyl, allyl, or propargyl, where C1-C4 alkyl, allyl, or propargyl is optionally substituted with C3-C6 cycloalkyl and where C1-C4 alkyl is optionally substituted with, -OR 7 , -S(0) n R 12 or -CO2R 7 ; R5 is independently at each occurrence C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C6 cycloalkyl, C4-C12 cycloalkylalkyl, -NO2, halo, -CN, C1-C4 haloalkyl, -NR 6 R 7 , NR 8 COR 7 , NR 8 C0 2 R 7 , -COR 7 -OR 7 , -C0NR 6 R 7 , -CO(NOR 9 )R 7 , CO2R 7 , or -SC0) n R 7 , where C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C6 cycloalkyl and C4- C12 cycloalkylalkyl are optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C4 alkyl, -NO2, halo, -CN, -NRδR 7 , -NR6R 7 , NR 8 COR 7 , NR 8 C0 2 R 7 , -COR 7 -OR 7 , -CONR 6 R 7 , CO2R 7 , -CO(NOR 9 )R 7 , or -S(0) n R 7 ; R6 and R7 are independently at each occurrence H, C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3-C6 cycloalkyl, C4-C12 cycloalkylalkyl, aryl, aryl(Cι-C4 alkyl)-, heteroaryl or heteroaryl (C1-C4 alkyl)-; or NR 6 R 7 is piperidine, pyrrolidine, piperazine, N- methylpiperazine, morpholine or thiomorpholine; R 8 is independently at each occurrence H or C1 . -C4 alkyl; R 9 and R 1 ^ are independently at each occurrence selected from H, C1-C4 alkyl, or C3-C6 cycloalkyl; R 11 is H, C1-C4 alkyl, C1-C4 haloalkyl, or C3-C6 cycloalkyl; R 12 is C1-C4 alkyl or C1-C4 haloalkyl; R 13 is C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3-C6 cycloalkyl, C4- C12 cycloalkylalkyl, aryl, aryl(Cι-C4 alkyl)-, heteroaryl or heteroaryl (C1 . -C4 alkyl)-; aryl is phenyl or naphthyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, halo, C]_- C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -0C(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 Cθ2R 13 , -NR 6 R 7 , and -CONR 6 R 7 ; heteroaryl is pyridyl, pyrimidinyl, triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzthiazolyl, isoxazolyl , pyrazolyl, triazolyl, tetrazolyl, or indazolyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from Cχ-C6 alkyl, C3-C6 cycloalkyl, halo, Ci- C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 Cθ2R 13 , -NR 6 R 7 , and -CONR 6 R 7 ; heterocyclyl is saturated or partially saturated heteroaryl, optionally substituted with 1 to 3 substituents independently selected at each occurrence from Ci-Cδ alkyl, C3-C6 cycloalkyl, halo, C1-C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 - -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 Cθ2R 13 , -NR 6 R 7 , and -CONR 6 R 7 ; n is independently at each occurrence 0, 1 or 2; provided that R 4 in formula I is not H: (a) when X is N, Y is N, z is NR 3 , R 1 is H, R 3 is H or benzyl, and Ar is p-methylphenyl; (b) when X is N, Y is N, Z is NR 3 , R 1 is butyl, R 3 is benzyl, and Ar is phenyl; (c) when X is N, Y is CH, Z is NR 3 , R 3 is methyl, R 1 is H, and Ar is phenyl or 2-fluorophenyl; (d) when X is N, Y is CH, Z is NR 3 , R 3 is methyl, R 1 is Cl and Ar is phenyl; (e) when X is N, Y is CH, Z is NR 3 , R 1 is Cl, R 3 is benzyl, and Ar is phenyl or substituted phenyl; (f) when X is N, Y is CH, Z is NR 3 , R 3 is p- methylbenzyl, and Ar is phenyl; (g) when X is N, Y is CR 2 , Z is NR 3 , R 2 is CH 3 , R 3 is H, and Ar is phenyl or phenyl substituted with methyl, ethyl, isopropyl, fluoro or chloro; (h) when X is N, Y is N, Z is NR 3 , R3 is cyclopropylmethyl, Rl is H, and Ar is 2-bromo-4- isopropylphenyl, or (i) when X is N, Y is N, Z is S, R 1 is H, and Ar is 2-bromo-4-isopropylphenyl. Preferred compounds of this invention are compounds of formula I and formula II and pharmaceutically acceptable salts and pro-drug forms thereof, wherein, independently or concurrently: X is N or CR 1 ; Y is N or CR 2 ; Z is NR 3 , 0, or S(0) n ; G is 0 or S; Ar is phenyl or pyridyl, each optionally substituted with 1 to 3- R 5 groups; R 1 is independently at each occurrence H, C 1 -C 4 alkyl, halo, CN, C 1 -C 4 haloalkyl, -NR 9 R 10 , -OR 11 or -S ( 0 ) n R 12 ; R 2 is H, C 1 -C 4 alkyl, Cι-C 6 cycloalkyl, halo, CN, -NR 6 R 7 , NR 9 COR 10 , C1-C4 haloalkyl, -OR 7 or -S(0) n R 12 ; R 3 is H, C 1 -C 10 alkyl, C 2 -C 1 0 alkenyl, C 2 -C 10 alkynyl, C 3 - Cβ cycloalkyl or C4-C 1 2 cycloalkylalkyl each optionally substituted with 1 to 3 substituents independently selected at each occurrence from Ci- Ce alkyl, C3-C6 cycloalkyl, halo, C 1 -C 4 haloalkyl, cyano, -OR 7 , -S(0) n R 13 , -C0 2 R 7 , -NR 8 COR 7 , -NR 8 CONR 6 R 7 , -NR 8 C0 2 R 13 , -NR 6 R 7 , aryl and heteroaryl, where the aryl or heteroaryl is optionally substituted with 1 to 3 substituents independently selected at each occurrence from Ci- C alkyl, halo, cyano, -OR 7 , -S(0) n R 7 , -CO2R 7 , -NR 8 COR 7 , -NR 8 CONR 6 R 7 , -NR 8 C0 2 R 7 , and -NR 6 R 7 ; R 4 is H, C1-C4 alkyl, allyl, or propargyl; R 5 is independently at each occurrence Ci-Cβ alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, C4-C8 cycloalkylalkyl, -N0 2 , halo, -CN C 1 -C 4 haloalkyl, -NR 6 R 7 , COR 7 -OR 7 , -CONR 6 R 7 , -CO(NOR 9 )R 7 , C0 2 R 7 , or -S(0) n R 7 / where Cι-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C6 cycloalkyl and C4-C12 cycloalkylalkyl are optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C4 alkyl, -NO 2 , halo, -CN, -NR 6 R 7 , COR 7 ' -OR 7 , -CONR 6 R 7 , C0 2 R 7 , -CO(NOR 9 )R 7 , or -S ( 0 ) n R 7 ; R6 and R7 are independently at each occurrence H, C1-C4 alkyl, . C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3- C6 cycloalkyl, C4-C12 cycloalkylalkyl, aryl, aryl(Cι-C4 alkyl)-, heteroaryl or heteroaryl(C1-C4 alkyl)-; or NR 6 R 7 is piperidine, pyrrolidine, piperazine, N-methylpiperazine, orpholine or thiomorpho1ine; R 8 is independently at each occurrence H or C1-C4 alkyl; R 9 and R 10 are independently at each occurrence selected from H, C1-C4 alkyl, or C3-C6 cycloalkyl; R 11 is H, C1-C4 alkyl, C1-C4 haloalkyl, or C 3 -C6 cycloalkyl; R 12 is C1-C4 alkyl or C1-C4 haloalkyl; R 13 C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3-C6 cycloalkyl, C4-C12 cycloalkylalkyl, aryl, aryl(Cι-C4 alkyl)-, heteroaryl or heteroaryl(C1-C4 alkyl) -; aryl is phenyl or naphthyl optionally substituted with 1 to 3 substituents independently selected at each occurrence from C 1 -C 4 alkyl, halo, cyano, -OR 7 , -S(0) n R 12 / -CO2R 8 , -NR 8 COR 7 , -NR 8 CONR 6 R 7 , -NR 8 Cθ 2 R 12 , and -NR 6 R 7 ; heteroaryl is pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, isoxazolyl, pyrazolyl, triazolyl, tetrazolyl, or indazolyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C 1 -C 4 alkyl, halo, cyano, -OR 7 , -S(0) n R 12 , -C0 2 R 8 , -NR 8 COR 7 , -NR 8 CONR 6 R 7 , -NR 8 C0 2 R 12 , and -NR6R 7 ; n is independently at each occurrence 0, 1 or 2. Of the preferred compounds, more preferred are those of formula I wherein Z is NR 3 and pharmaceutically acceptable salts and pro-drug forms thereof. Included in this invention is the method of treating affective disorder, anxiety, depression, irritable bowel syndrome, post-traumatic stress disorder, supranuclear palsy, immune suppression, Alzheimer's disease, gastrointestinal disease, anorexia nervosa or other feeding disorder, drug or alcohol withdrawal symptoms, drug addiction, inflammatory disorder, or fertility problem in a mammal comprising administering to the mammal a therapeutically effective amount of a compound of formula I or II. Also included m this invention are pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of any one of the above-described compounds. This invention also includes intermediate compounds useful m preparation of the CRF antagonist compounds and processes for making those intermediates, as described in the following description and claims. The CRF antagonist compounds provided by this invention (and especially labelled compounds of this invention) are also useful as standards and reagents in determining the ability of a potential pharmaceutical to bind to the CRF receptor. DETAILED DESCRIPTION OF INVENTION Many compounds of this invention have one or more asymmetric centers or planes. Unless otherwise indicated, all chiral (enantiomeric and diastereomeric) and racemic forms are included in the present invention. Many geometric isomers of olefins, C=N double bonds, and the like can also be present in the compounds, and all such stable isomers are contemplated in the present invention. The compounds may be isolated in optically active or racemic forms. It is well known in the art how to prepare optically active forms, such as by resolution of racemic forms or by synthesis from optically active starting materials. All chiral, (enantiomeric and diastereomeric) and racemic forms and all geometric isomeric forms of a structure are intended, unless the specific stereochemistry or iso er form is specifically indicated. The term "alkyl" includes both branched and straight-chain alkyl having the specified number of carbon atoms. "Alkenyl" includes hydrocarbon chains of either a straight or branched configuration and one or more unsaturated carbon-carbon bonds which may occur in any stable point along the chain, such as ethenyl, propenyl, and the like. "Alkynyl" includes hydrocarbon chains of either a straight or branched configuration and one or more triple carbon-carbon bonds which may occur in any stable point along the chain, such as ethynyl, propynyl and the like. "Haloalkyl" is intended to include both branched and straight-chain alkyl having the specified number of carbon atoms, substituted with 1 or more halogen; "alkoxy" represents an alkyl group of indicated number of carbon atoms attached through an oxygen bridge; "cycloalkyl" is intended to include saturated ring groups, including mono-,bi- or poly-cyclic ring systems, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and so forth. "Halo" or "halogen" includes fluoro, chloro, bromo, and iodo. The term "substituted", as used herein, means that one or more hydrogen on the designated atom is replaced with a selection from the indicated group, provided that the designated atom's normal valency is not exceeded, and that the substitution results in a stable compound, when a substitent is keto (i.e., =0) , then 2 hydrogens on the atom are replaced. Combinations of substituents and/or variables are permissible only if such combinations result in stable compounds. By "stable compound" or "stable structure" is meant a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into an efficacious therapeutic agent. The term "appropriate amino acid protecting group" means any group known in the art of organic synthesis for the protection of amine or carboxylic acid groups. Such amine protecting groups include those listed in Greene and Wuts, "Protective Groups in Organic Synthesis" John Wiley & Sons, New York (1991) and "The Peptides: Analysis, Synthesis, Biology, Vol. 3, Academic Press, New York (1981), the disclosure of which is hereby incorporated by reference. Any amine protecting group known in the art can be used. Examples of amine protecting groups include, but are not limited to, the following: 1) acyl types such as formyl, trifluoroacetyl, phthalyl, and p-toluenesulfonyl; 2) aromatic carbamate types such as benzyloxycarbonyl (Cbz) and substituted benzyloxycarbonyls, 1- (p-biphenyl)-1- methylethoxycarbonyl, and 9-fluorenylmethyloxycarbonyl (Fmoc) ; 3) aliphatic carbamate types such as tert-butyloxycarbonyl (Boc) , ethoxycarbonyl, diisopropyl ethoxycarbonyl, and allyloxycarbonyl; 4) cyclic alkyl carbamate types such as cyclopen-tyloxycarbonyl and adamantyloxycarbonyl; 5) alkyl types such as triphenylmethyl and benzyl; 6) trialkylsilane such as trimethylsilane; and 7) thiol containing types such as phenylthiocarbonyl and dithiasuccinoyl. The term "amino acid" as used herein means an organic compound containing both a basic amino group and an acidic carboxyl group. Included within this term are natural amino acids, modified and unusual amino acids, as well as amino acids which are known to occur biologically in free or combined form but usually do not occur in proteins. Included within this term are modified and unusual amino acids, such as those disclosed in, for example, Roberts and Vellaccio (1983) The Pen ides. 5: 342-429, the teaching of which is hereby incorporated by reference. Modified or unusual amino acids which can be used to practice the invention include, but are not limited to, D-amino acids, hydroxylysine, 4-hydroxyproline, an N-Cbz-protected amino acid, ornithine, 2,4-diaminobutyric acid, homoarginine, norleucine, N-methylaminobutyric acid, naphthylalanine, phenylglycine, β-phenylproline, tert-leucine, 4-aminocyclohexylalanine, N-methyl- norleucine, 3,4-dehydroproline, N,N- dimethylaminoglycine, N-methylaminoglycine, 4-aminopiperidine-4-carboxylic acid, 6-aminocaproic acid, trans-4- (a inomethyl) -cyclohexanecarboxylic acid, 2-, 3-, and 4-(aminomethyl)-benzoic acid, 1-aminocyclopentanecarboxylic acid, 1-aminocyclopropanecarboxylic acid, and 2-benzyl-5- aminopentanoic acid. The term "amino acid residue" as used herein means that portion of an amino acid (as defined herein) that is present in a peptide. The term "peptide" as used herein means a compound that consists of two or more amino acids (as defined herein) that are linked by means of a peptide bond. The term "peptide" also includes compounds containing both peptide and non-peptide components, such as pseudopeptide or peptide mimetic residues or other non-amino acid components. Such a compound containing both peptide and non-peptide components may also be referred to as a "peptide analog". The term "peptide bond" means a covalent amide linkage formed by loss of a molecule of water between the carboxyl group of one amino acid and the amino group of a second amino acid. The term "pharmaceutically acceptable salts" includes acid or base salts of the compounds of formulas (I) and (II) . Examples of pharmaceutically acceptable salts include, but are not limited to, mineral or organic acid salts of basic residues such as amines; alkali or organic salts of acidic residues such as carboxylic acids; and the like. Pharmaceutically acceptable salts of the compounds of the invention can be prepared by reacting the free acid or base forms of these compounds with a stoichiometric amount of the appropriate base or acid in water or in an organic solvent, or in a mixture of the two; generally, nonaqueous media like ether, ethyl acetate, ethanol, isopropanol, or acetonitrile are preferred. Lists of suitable salts are found in Remington's Pharmaceutical Scifinc.es. 17th ed. , Mack Publishing Company, Easton, PA, 1985, p. 1418, the disclosure of which is hereby incorporated by reference. "Prodrugs" are considered to be any covalently bonded carriers which release the active parent drug of formula (I) or (II) in vivo when such prodrug is administered to a mammalian subject. Prodrugs of the compounds of formula (I) and (II) are prepared by modifying functional groups present in the compounds in such a way that the modifications are cleaved, either in routine manipulation or in vivo, to the parent compounds. Prodrugs include compounds wherein hydroxy, amine, or sulfhydryl groups are bonded to any group that, when administered to a mammalian subject, cleaves to form a free hydroxyl, amino, or sulfhydryl group, respectively. Examples of prodrugs include, but are not limited to, acetate, formate and benzoate derivatives of alcohol and amine functional groups in the compounds of formulas (I) and (II); and the like. The term "therapeutically effective amount" of a compound of this invention means an amount effective to antagonize abnormal level of CRF or treat the symptoms of affective disorder, anxiety or depression in a host. Synthesis The bicylic fused pyrimidine and pyridines of this invention can be prepared by one of the general schemes outlined below (Scheme 1-9) . Compounds of the Formula (I) wherein X=Y=N and Z=NR , can be prepared as shown in Scheme 1. Scheme 1 wherein X=Y=N; The 4, 6-dihydroxypyrimidines (III) can be nitrated using fuming nitric acid and then converted into intermediates (IV) by the action of phosphorous oxychloride with the optional assistance of a catalyst such as dialkylanilines (see: Brown, D.J. et.al. J. Chem . Soc , 1954, 3832) . The amino group of pyrimidines of Formula (V) can be prepared from the corresponding nitro compounds (IV) by treatment with reducing agents such as, but not limited to, sodium dithionate, iron or zinc, or catalytic hydrogenation (see: Larock, R.C. Comprehensive Organic Transformations, .VCH Publishers, New York, 1989, 411). Reaction with Ar-NH2 can.be used to provide compounds of Formula (VI) . Conditions which may facilitate this transformation include the optional presence of protic or aprotic acids, or bases such as alkali metal hydrides, trialkylamines, or alkali metal carbonates, or alkali metal bis(trimethylsilyl)amides wherein the metal can be sodium, lithium, or potassium. These reactions may be conducted neat, or in the optional presence of solvents such as but not limited to cyclic ethers such as tetrahydrofuran, dialkylformamides, ethylene glycol, 2-ethoxyethanol, halocarbons, alkanenitriles, or alkyl alcohols at room temperature or at elevated temperature up to the boiling point of the solvent employed. One skilled in the art of organic synthesis will readily understand the optimal combinations of these conversions to prepare a number of compounds of Formula (VI) . Cyclization to triazolopyrimidines of Formula (VII) can then be readily accomplished by diazotization and cyclization of the diamino compounds of Formula (VI) with an alkali metal nitrite in the presence of acid in water with or without an organic cosolvent such as halocarbons, or cyclic ethers. Treatment of compound of Formula (VII) with primary amines then can provide the intermediates (VIII) using reaction conditions similar to those employed for the conversion of (V) to (VI) . The rearranged triazolopyrimidine of Formula (IX) may be obtained from the triazolopyrimidine of Formula (VIII) by treatment with base such as but not limited to, alkali metal hydrides, alkaline earth metal hydrides, alkali metal dialkyl amides in inert solvents such as dialkylformamides, dialkylacetamides at temperatures ranging from 0 ° to 200 °C. Finally, reaction with an appropriate R 4 L wherein L is a suitable leaving group such as halo, methanesulfonate, p-toluenesulfonate, or triflate in the presence or absence of bases- such as but not limited to, alkali metal hydrides, alkaline earth metal hydrides, alkali metal dialkyl amides in inert solvents such as dialkylformamides or dialkylacetamides at temperatures ranging from 0 ° to 200 °C can be used to generate compounds of Formula (I) . Alternatively, compounds of Formula (I) wherein X=Y=N and Z=NR 3 , of this invention can be prepared as outlined in Scheme 2: Scheme 2 wherein X=Y=N, Z=NR 3 Treatment of compound of Formula (V) with primary amines can provide the diamino substituted pyrimidines (X) . Conditions which facilitate this transformation are detailed previously for the conversion of (VII) to (VIII) . Cyclization to triazolopyrimidines of Formula (XI) can then be readily accomplished by following the conditions already described for the conversion of (VI) to (VII) in Scheme 1. The leaving group such as, but not limited to, halogen can then be displaced by addition of Ar-NH2 to provide compounds of Formula (IX) by utilizing the conditions described for the conversion of (V) to (VI) . Compounds of Formula (IX) can be converted to (I) in the same way as outlined in Scheme 1. Compounds of the Formula (VI) can also prepared by an another approach (Scheme 3) involving addition of Ar-NH2 to (IV) to afford compounds of Formula (XII) . Scheme 3 The nitro group in (XII) can be reduced to give compounds of Formula (VI) under conditions similar to those described for the transformation of (IV) to (V) in Scheme 1. Alternatively, as shown in Scheme 3, addition of Ar-NH2 to compounds of Formula (IV) can generate in-situ the pyrimidones (XIII) . For example, treatment of dichloropyrimidines of Formula (IV) with one equivalent of Ar-NH2 in the presence of solvents such as (but not limited to) dialkylsulfoxides, dialkylformamides, and alkyl alcohols readily generate pyrimidones (XIII) . Compounds of Formula (XIII) can be converted into (IV) by the action of phosphorous oxychloride with the optional assistance of a catalyst such as dialkylanilines with or without an inert solvent. Compounds of Formula (VI) are elaborated to structures of Formula (I) as previously shown in Scheme 1. Scheme 4 outlines another route to fused triazolopyrimidine type of compounds of this invention. Scheme 4 XIV XV I wherein X=Y=N; Z=NR 3 4, 6-dihydroxy-5-nitropyrimidines can be treated with aryl sulfonic anhydrides, aryl sulfonyl chlorides, alkyl sulfonic anhydrides or alkyl sulfonyl chlorides in the presence or absence of bases such as alkali metal hydrides, alkaline earth metal hydrides, alkali metal dialkyl amides in inert solvents such as dialkylformamides, dialkylacetamides at temperatures ranging from 0 ° to 200 °C to give intermediates of Formula (XIV) . Compounds of Formula (XIV) are treated with primary amines to give aminonitropyrimidines (XV) . Treatment of (XV) with Ar-NH2 can provide compounds of Formula (XVI) . Compounds of the formula (XVI) can be reduced to amino derivatives (XVII) using the reagents described for the conversion of (IV) to (V) in Scheme 1.. Intermediate (XVII) can be converted to a mixture of (VIII) and (IX) by diazotization and cyclization. Compounds of the Formula (VIII) can be converted to (IX) by treatment with base such as but not limited to, alkali metal hydrides, alkaline earth metal hydrides, alkali metal dialkyl amides in an inert solvent. Compounds of Formula (IX) are elaborated to give (I) as delineated m Scheme 1. Fused lmidazolopyπmidines of the Formula (I) wherein X=N, Y=CR 2 , and Z=NR 3 , can be prepared from compound (X) as shown in Scheme 5. Scheme 5 »3 N Ml _. acylating agent, NV NHz acid, heat R N Cl X XVIII ArNH 2 , heat XIX Treatment of (X) with an acylating agent such as, but not limited to, alkyl anhydrides, haloalkyl anhydrides, alkylamides, haloalkyl amides, trialkylorthoesters R (OR)3 (where R is C1-C4 alkyl) , guanidines, cyanogen bromide, R 2 COOH, urea or thiourea in the presence or absence of an acid (such as HOAc, HCl, H2SO4) in the presence or absence of an organic cosolvent such as alkyl alcohols, cyclic ethers, or aromatic solvents at temperatures ranging from 0 ° to 200 °C. Treatment of (XVIII) with Ar-NH2 can provide compounds of Formula (XIX) . Finally, alkylation of compound (XIX) can provide imidazolopyrimidine (I, wherein X=N, Y=CR 2 , Z=NR 3 ). The 1,2, 3-thiadiazolo[5,4-d]pyrimidines of the formula (I) (wherein X=Y=N and Z=S) , can be prepared as shown in Scheme 6. Scheme 6 wherein X=Y=N, Z=S Compounds of the formula (VII) with thiourea can react upon heating in presence of solvents such as but not limited to, cyclic ethers such as tetrahydrofuran, dialkylformamides such as dimethylformamide, dialkyl acetamides, . eth ' ylene glycol, 2-ethoxyethanol, halocarbons such as methylene chloride, alkanenitriles such as acetonitrile, or alkyl alcohols such as methanol, ethanol to give compound (XX) which is alkylated to afford thiadiazolpyrimidine (I) (wherein X=Y=N and Z=S) . Compounds of Formula (I) can be converted to sulfoxides as well sulfones under a variety of oxidizing agents such as but not limited to , NaIθ4, K nθ4 or m-chloroperbenzoic acid. The method of synthesis of the triazolopyridines of this invention is shown in Scheme 7. The hydroxy groups in (XXI) can be converted into chloro groups by the action of phosphorous oxychloride with the optional assistance of a catalyst such as dialkylaniline (see: Brown, D.J. et.al. J. Chem. Soc , 1954, 3832) to afford compounds of Formula (XXII) . Addition of primary amines to compound (XXII) can provide alkylaminonitropyridines (XXIII) . The nitro group in (XXIII) can be reduced using the conditions employed for the transformation of (IV) to (V) to give (XXIV) . Diazotization and cyclization of (XXIV) can provide chlorotriazolopyridine derivatives (XXV) as was described for the conversion of (VI) to (VII) in Scheme 1. The chloro group can then be displaced by addition of Ar-NH2 to afford compounds (XXVI) and then treated with R 4 L to give (I) . Imidazolopyridines of the present invention can be prepared from compound (XXIV) as shown in Scheme 7 by following the conditions outlined for the conversion of (X) to (XVIII) in Scheme 5. Treatment of compound (XXVII) with Ar-NH2 using the conditions outlined in Scheme 1 can provide compounds of Formula (I, where R =H) . Alkylation with R L can afford imidazolopyridines of formula I (where R 4 is not equal to H) . Alternatively, the triazolopyridines can be synthesized as shown in Scheme 8. Treatment of compounds of Formula (XXI) with an aliphatic or aromatic amine in the appropriate organic solvent but not limited to, alkyl alcohols such as methanol, ethanol, propanol, butanol, alkyl alkanoates such as ethyl acetate, alkanenitriles such as acetonitrile, dialkyl formamides such as DMF gives the corresponding ammonium salt, which upon treatment with POCI3 at temperatures from 25 to 120 C, give compounds of Formula (XXVIII) . Treatment of compounds of Formula (XXVIII) with appropriate primary amines in an organic solvent such as but not limited to, alkyl alcohols such as methanol, ethanol, propanol, butanol, alkyl alkanoates such as ethyl acetate, alkanenitriles such as acetonitrile, dialkyl formamides such as DMF, dialkylsulfoxides at temperatures from 25 to 120 °C to give (XXIX) . This was converted to (XXIII) by treatment with POCI3 at temperatures from 25 to 120 C. Compounds of Formula (XXIII) could be coupled with Ar-NH2 with or without the presence of solvent at temperatures from 25 to 200 C to give product (XXX) . These could be converted to intermediates (XXXI) by reduction of the nitro group under a variety of reducing conditions, such as those used for the conversion of (IV) to (V) in Scheme 1. The final cyclizaton was carried out as described for the conversion of (VI) to (VII) in Scheme 1. Compounds of general formula (II) may be prepared according to the procedures outlined in Scheme 9. Scheme 9 , (XXXV) base, R 4 L, solvent (XXXVI) Intermediates of formula (X) , (XV) or (XXIV) may be converted to compounds of formula (XXXIII) by treatment with an acylating agent in the presence or absence of a base in an inert solvent at reaction temperatures ranging from -78 C to 200 °C. Acylating agents include, but are not limited to, phosgene, thiophosgene, diphosgene, triphosgene, carbonyl diimidazole, thiocarbonyl diimidazole, dialkylcarbonates (such as diethyl carbonate) or R a R b N(C=G)OR c (where G= 0,S; R a , R b , and R c are independently C1-C8 alkyl). Bases include, but are not limited to, alkali metal alkoxides, akali metal hydrides, trialkyl amines, pyridine, 4- dimethyla inopyridine, alkali metal dialkyl amides or alkali metal bis(trimethylsilyl)amides. Inert solvents include, but are not limited to, halocarbons, alkanenitriles, dialkylformamides, dialkylacetamides, dialkyl ethers, cyclic ethers such as tetrahydrofuran or dioxane, or alkyl alcohols. Intermediates of (XXXIII) may be converted to compounds of formula (XXXIV) (Formula (II) where R 4 = H) by reaction with ArNH2, using the conditions described for the conversion of compound (V) to (VI) in Scheme 1. Compounds of Formula (XXXV) may be prepared from compounds of structure (XXXIII) by reaction with R 13 L ( where L is a leaving group such as halide, alkanesulfonate or arylsulfonate) in the presence or absence of a base in an inert solvent. Bases and inert solvents may be the same as those listed above for the preparation of (XXXIII) . Intermediates of Formula (XXXV) can be reacted with ArNH2 to give compounds of formula (XXXVI) (Formula (II), where R 4 = H) using the conditions described for the conversion of compound (V) to (VI) in Scheme 1. Compounds of Formula (XXXVI) may be converted to compounds of (XXXVII) (Formula (II), where R 4 does not equal H) by treatment with R 4 L ( where L is a leaving group such as halide, alkanesulfonate or arylsulfonate) in the presence or absence of a base in an inert solvent. Bases and inert solvents may be the same as those listed above for the preparation of (XXXIII) . As illustrated in Scheme 10, treatment of compounds of Formula (XXI) with an aliphatic or aromatic amine in an appropriate organic solvent (such as but not limited to, alkyl alcohols such as methanol, ethanol, propanol, butanol, alkyl alkanoates such as ethyl acetate, alkanenitriles such as acetonitrile, dialkyl formamides such as DMF) gives the corresponding ammonium salt, which upon treatment with POCI3 at temperatures from 25 to 120 C, give compounds of Formula (XXVIII) . Treatment of compounds of Formula (XXVIII) with appropriate primary amines R 3 NH 2 in an organic solvent (such as but not limited to, alkyl alcohols such as methanol, ethanol, propanol, butanol, alkyl alkanoates such as ethyl acetate, alkanenitriles such as acetonitrile, dialkyl formamides such as DMF, dialkylsulfoxides) at o temperatures from 25 to 120 C provides compounds of Formula (XXIX) . These can be converted to (XXIII) by treatment with POCI3 at temperatures from 25 to 120 C. Compounds of Formula (XXIII) can be converted to intermediates (XXIV) by reduction of the nitro group under a variety of reducing conditions, such as those used for the conversion of (IV) to (V) in Scheme 1. Diazotization and cyclization of (XXIV) can provide chlorotriazolopyridine (XXV) as was described for the conversion of of (VI) to (VII) in Scheme I. The chloro group can then be displaced by addition of Ar-NH 2 in the presence of an acid such as but not limited to HCl, H 2 SO 4 , AcOH, methanesulfonic acid, p- toluenesulfonic acid in inert solvents such as toluene, xylenes at temperatures ranging from 0 ° to 200 °C to afford product I. Salts of I are prepared by combining the free base with appropriate acid in a suitable organic solvent. Scheme 10 POCI3 reducing agents XXV XXIV XXIII acid addition salt of I wherein X=CR 1 , Y=N, Z=NR 3 As shown in Scheme 11, reaction of a 4-amino-3- nitro-pyridone of formula (XXIX) with a reducing agent, such as Na 2 ≤ 2 θ 4 affords the corresponding 4-amino-3- amino-pyridone of formula (XXXVII) . This transformation can be effected under a variety of reducing conditions, such as catalytic hydrogenation, reducing metal reaction (Fe, Sn, Zn) , hydride reaction (NaBH 4 , LiAlH 4 ) etc., which are known to those skilled in the art. The 4- amino-3-amino-pyridone can be converted to the triazolopyridone of formula (XXXVIII) by treatment with an alkali metal nitrite, such as NaNθ 2 , under acidic conditions. The resulting triazolopyridone can be converted to the corresponding halo-triazolopyridine of formula (XXXIX) (X= Cl, Br) , by treatment with a halogenating agent such as P0C1 3 , PBr 3 , POBr . Alternatively X can be an appropriate leaving group resulting from treatment of the triazolopyridone with triflie, tosic or mesyl anhydride in the presence of a base. The triazolopyridine can be coupled with aryla ines ArNH2 under acidic, basic or thermal catalysis to compounds of Formula I. Scheme 11 XXXIX Example 1 N- [2-bromo-4- ( 1-methylethyl)phenyl] -5-methyl-3- propyl-3JΪ-l, 2,3-triazolo[4, 5-d]pyrimidin-7- amine Part A: 4, β-Dihydroxy-2-methylpyrimidine (60 g) was added in portions to fuming nitric acid (120 mL) at 0 °C while cooling the reaction flask. After completion of addtion, the reaction was stirred an additional 1 h at 0 °C followed by another 1 h at room temperature. The reaction mixture was then poured over ice (200 g) and the ice was allowed to melt. A light pink solid was isolated by filteration and washed with cold water (100 L) . The solid was dried in a vacuum oven overnight to yield 4,6- dihydroxy-2-methyl-5-nitropyrimidine (72.5 g) . Part B: The product of Part A was added portionwise to phosphorous oxychloride (400 mL) under a nitrogen atmosphere followed by dropwise addition of N,N-diethylaniline (80 mL) . The reaction mixture was refluxed for 2 1/2 h with stirring, cooled to room temperature, poured over ice (2.0 Kg) and stirred for 1 hr. The aqueous layer was extracted with diethyl ether (4 x 500 mL) and the extracts combined. The combined extracts were washed with brine (500 mL) , dried over anhydrous magnesium sulfate, filtered and stripped down to afford 4, 6-dichloro-2-methyl-5- nitropyrimidine as a yellow solid (68.8 g) which has an unpleasant odor. Part C: The product of Part B (42 g) was added to acetic acid (77 mL) and methanol (350 mL) . To this mixture was added iron powder (42 g) in portions, stirred for 2 h at 60-65 °C, cooled to room temperature, and filtered. The filterate was stripped to a brown solid., which was extracted with ethyl acetate ( 2 x 500 mL) , washed with IN NaOH (250 mL) , and brine (500 mL) . The organic layer was dried over anhydrous magnesium sulfate, filtered and stripped down to yield 5-amino-4,6-dichloro-2-methylpyrimidine as a pale yellow solid (25.4 g) . Part D: The product of Part C (14.2 g) and 2- bromo-4-isopropylaniline (17.1 g) were dissolved in 2- ethoxyethanol (60 mL) and refluxed at 135 °C for 30 h. The reaction mixture was cooled, removed the solvent, extracted the residue with dichloromethane, washed with water, dried over anhydrous magnesium sulfate. Filtered the extract, removed the solvent and residue was purified by flash column chromatography on a silica gel using methanol + CH2CI2 (1:100) to yield 5- amino-4- (2-bromo-4-isopropylphenyl)- amino-6-chloro-2- methylpyrimidine as a cream colored solid (16.05 g) . Part E: The product of Part D (12.5 g) was dissolved in dichloromethane (125 mL) and 50 % aqueous acetic acid (125 mL) . To this stirred mixture was added sodium nitrite (2.55 g) in water (10 mL) dropwise at room temperature. After completion of addition, the reaction was stirred for an additional 15 ins. The organic layer was separated, washed with water, dried with anhydrous magnesium sulfate, and stripped down to a residue. The residue was purified by flash column chromatography (CH2CI2) to afford light brown oil. The oil was crystallized from 1:1 hexane + pentane (15 mL) to yield 3- [2-bromo-4- (1- methylethyl)phenyl] -7-chloro-5-methyl -3H-1,2,3- triazolo[4, 5-d]pyrimidine as an off-white solid (12.15 g). Part P: The product of Part E (0.65 g) was dissolved in dichloromethane (20 mL) and then added 1.0 g of 1-propylamine at room temperature. The reaction mixture was stirred at room temperature for 1 h, washed with water, dried with anhydrous magnesium sulfate, and stripped down to a white solid. The crude solid was recrystallized from 2-propanol (2 mL) to furnish 3- [2-bromo-4- (1-methylethyl)phenyl] -5- methyl-N-propyl-3H-l, 2, 3-triazolo[4, 5-d]pyrimidin-7- amine as a white needles (0.58 g; mp 156-157 °C) . Elemental analysis for Ci7H2lBrΝ : Theory C: 52.45, H: 5.45, N: 21.59. Found: C: 52.47, H: 5.33, N: 21.46. Part G: Rearrangement of Product P: The product of Part F (0.40 g) was dissolved in dry DMF (10 mL) and added NaH (0.103 g, 60% in oil) at room temperature under a nitrogen atmosphere. The mixture was stirred at room temperature for 14 h and partitioned between ethyl acetate (25 L) and water (25 mL) . The organic layer was washed with brine, dried, and stripped in vacuum to a solid. The solid was recrystallized from 2-propanol (0.5 mL) to afford the title compound as a white crystalline solid (0.35 g; mp 80-81 °C) . Elemental analysis for Ci7H2lBrN6: Theory C: 52.45, H: 5.45, N: 21.59. Found: C: 52.19, H: 5.37, N: 21.48. Example 2 N- [2-bromo-4- (1-methylethyl)phenyl] -N-ethyl-5- methyl-3-propyl-3ff-l,2,3-triazolo[4,5-d] pyrimidin-7-amine The title compound from Example 1 (0.30 g) was dissolved in dry DMF (10 mL) and added NaH (62 mg; 60 % in oil) at room temperature under a nitrogen atmosphere. The reaction mixture was stirred for 5 ins., and then added EtI (0.2 mL) and continued for an additional 24 h. The reaction mixture was partitioned between ethyl acetate (25 mL) and water (25 mL) , washed the organic layer with brine, dried, and stripped in vacuum to yield a pale yellow oil. The sample was purified by flash column chromatography (1:100 MeOH + CH2CI2) to afford the title compound as a colorlesss oil (0.16 g) . Elemental analysis for Cl9H25BrN6: Theory C: 54.68, H: 6.05 Found: C: 54.66, H: 6.02. Example 3 N- [2-bromo-4- (1-methylethyl)phenyl] - 3 -butyl -N- ethyl-5-methyl-3J-'-l,2,3-triazolo[4,5- d]pyrimi in-7-amine Part A: The product of Part E from Example 1 was treated with 1-butylamine in the same manner as outlined in Part F to afford 3- [2-bromo-4- (1- methylethyl)phenyl] -N-butyl-5-methyl-3/ -l , 2 , 3- triazolo[4, 5-d]pyrimidin-7-amine as a white solid (mp 149-151 °C) . Elemental analysis for Ci8H23BrΝg: Theory C: 53.60, H: 5.76, N: 20.84. Found: C: 53.46, H: 5.62, N: 20.80. Part B: The product of Part A from Example 3 (0.34 g) was dissolved in dry DMF (10 mL) and added NaH (67 g; 60% in oil) at room temperature under a nitrogen atmosphere. The reaction mixture was stirred for 24 h, then added EtI (0.1 mL) and continued for another 24 hrs. The title compound was isolated in the same way as described in Example 2 to afford colorless oil (0.21 g) . Elemental analysis for C20H27BrN6: Theory C: 55.69, H: 6.32, N: 19.48. Found: C: 55.61, H: 6.19, N: 19.23. Example 4 N- [2-bromo-4- (1-methylethyl) phenyl] -3- ( cyclopropylmethyl) -W-ethyl-5-methyl-3ff-l, 2, 3- triazolo[4, 5-d]pyrimidin-7-amine Part A: The product of Part E from Example 1 was reacted with a inomethylcyclopropane in the same way as outlined in Part F to furnish 3- [2-bromo-4- (1- methylethyl) phenyl] -N- (cyclopropyl -methyl) - 5 -methyl - 3H-1, 2, 3-triazolo[4, 5-d]pyrimidin-7 -amine as a white needles (mp 166-167 °C) . Elemental analysis for Ci8H2 l BrΝ6: Theory C: 53.87, H: 5.27, N: 20.94. Found: C: 54.11, H: 5.32, N: 21.08. Part B: Using the procedure for Part G in Example 1, the product of Part A in Example 4 was rearranged to yield the title compound as a white crystalline solid (mp 100-101 °C) . Elemental analysis for Cl8H2lBr 6: Theory C: 53.87, H: 5.27, N: 20.94. Found: C: 53.93, H: 5.28, N: 20.78. Part C: Using the procedure for Example 2, the product of Part B from above was alkylated to furnish the title compound as a colorless oil. Elemental analysis for C20H25BrN6: Theory C: 55.95, H: 5.88, N: 19.57. Found: C: 56.11, H: 6.04, N: 19.23. Example 5 N- [2-bromo-4- ( 1 -methyl) ethylphenyl] -5-methyl-3- [ (1-methoxymethyl) -2-methoxyethyl) -3H-1, 2, 3- triazolo [4, 5-d]pyrimidin-7-amine Part A: Serinol (3.42 g) was added to a solution of trityl chloride (8.36 g) and triethylamine in 75 mL of dry DMF. After stirring at room temperature overnight, the reaction was poured into water and extracted twice with toluene. The combined organic layers were dried over potassium carbonate and concentrated to dryness. Recrystallization from boiling 1:1 benzene/hexane (two crops) afforded N- triphenylmethylserinol (7.59 g) . Part B: Methyl iodide (2.60 mL) was added to a suspension of N-triphenylmethylserinol (6.34 g) and powdered sodium hydroxide (7.60 g) in 95 mL of dry DMSO. After stirring overnight, more methyl iodide was added (0.35 mL) . After stirring for an additional 24 h, the reaction was added to water and extracted with toluene, toluene/ether, and then ether. The combined organic layers were dried over potassium carbonate and concentrated to afford 1, 3-dimethoxy-2- triphenylmethylaminopropane (7.00 g) as a thick viscous oil. Part C: To a solution of the product of Part B (1.45 g) in methanol (32 mL) was added 1 M HCl in ether (8.4 mL) . After stirring overnight, the reaction was added to hexane and extracted with 1:1 methanol/water. The methanol/water layer was washed twice with hexane and concentrated to dryness to afford 1, 3-dimethoxy-2-aminopropane hydrochloride (600 mg) as a waxy solid. Part D: The product of Part C (576 mg) , 3- [2- bromo-4- (1-methyl) ethylphenyl] -7-chloro-5-methyl-3H- 1, 2,3-triazolo[4, 5-d] pyri idine (0.733 g, from Example 1, Part E) and triethylamine (0.56 mL) were stirred overnight at room temperature. The reaction mixture was added to aqueous sodium dihydrogen phosphate and extracted three times with dichloromethane. The combined organic layers were dried over magnesium sulfate and concentrated. Recrystallization from ether/hexane and then boiling methanol afforded N- (l-methoxymethyl-2-methoxyethyl) - 3- [2-bromo-4- (1-methyl) ethylphenyl] -5-methyl-3H-l,2, 3- triazolo[4,5-d]pyrimidin-7-amine (855 mg) as crystals melting 156.0-155.5°. Calculated for C19H25N602Br: C, 50.79%; H, 5.62%; N, 18.70%. Found: C, 50.48%; H, 5.65%; N, 18.41%. Part E: The product of Part D (449 mg) , dry t- butanol (8 mL) and 1 M potassium t-butoxide (2 mL) were heated at reflux for 2 h. The reaction mixture was added to saturated aqueous ammonium chloride and extracted with dichloromethane. The combined organic layers were dried over magnesium sulfate and concentrated to dryness. The residue crystallized after partial evaporation of a dichloro ethane/ether/hexane solution, affording the title compound (403 mg) as an amorphorus white solid melting 53.5-60.0°. Calculated for C19H25N602Br: C, 50.79%; H, 5.62%; N, 18.70%. Found: C, 50.92%; H, 5.62%; N, 18.77%. Example 6 N- [2-bromo-4- ( 1-methylethyl ) phenyl] -3- ( 2- ethoxyethyl) -5 -methyl -3H-1, 2, 3-triazolo [4, 5-d] pyr imi di n- 7 - ami ne Part A: The product of Part E from Example 1 was reacted with 2-methoxyethylamine in the same way as outlined in Part F to furnish 3- [2-bromo-4- (1- methylethyl) phenyl] -N- ( 2 -methoxyethyl ) -5-methyl-3H- l,2,3-triazolo[4, 5-d] yr imidin-7 -amine as a white solid (mp 134-136 °C) . Elemental analysis for Cl7H2lBr 6θ: Theory C: 50.38, H: 5.22, N: 20.74. Found: C: 50.37, H: 5.32, N: 20.52. Part B: Using the procedure for Part G in Example 1, the product of Part A in Example 6 was rearranged to yield the title compound as a white crystalline solid (mp 94-95 °C) . Elemental analysis for Cl7H2lBrN6θ: Theory C: 50.38, H: 5.22, N: 20.74. Found: C: 50.40,- H: 5.31, N: 20.65. Example 7 N- [2-bromo-4- ( 1-methylethyl) phenyl] -tf-ethyl-3- ( 2 - ethoxyethyl ) - 5 -methyl - 3 H- 1 , 2 , 3 - triazolo [4, 5-d] pyrimidin-7-amine Using the procedure for Example 2, the product of Part B in Example 6 was alkylated to furnish the title compound as a colorless oil. Elemental analysis for Cl H25Br 6θ: Theory C: 52.66, H: 5.81, N: 19.39. Found: C: 52.85, H: 5.96, N: 19.02. Example 8 N- [2-bromo-4- {1-methylethyl)phenyl] -N-ethyl-3- (3-methoxypropyl) -5-methyl-3JT-1, 2, 3- triazolo[4,5-d] pyrimi in-7-amine Part A: The product of Part E from Example 1 was treated with 3-methoxyethylamine in the same manner as outlined in Part F to afford 3- [2-bromo-4- (1-methylethyl)phenyl] -N-ethyl-N- (3-methoxypropyl) -5- methyl-3 f-l, 2, 3-triazolo[4, 5-d]pyrimidin-7-amine as a white solid (mp 109-110 °C) . Elemental analysis for Cl8H23BrΝ6θ: Theory C: 51.56, H: 5.54, N: 20.04. Found: C: 51.57, H: 5.40, N: 20.23. Part B: The product of Part A from Example 8 was rearranged and alkylated in the same way as outlined in Part B of Example 3 to furnish the title compound as a colorless oil. Elemental analysis for C20H27BrN6θ: Theory C: 53.69, H: 6.08, N: 18.79. Found: C: 53.63, H: 5.98, N: 18.59. Example 9 (+/- ) -N- [2-bromo-4- (1-methylethyl ) phenyl] -3- [1- ( l-methoxymethyi)propyl] -5 -methyl -3JJ-1, 2,3- triazolo [4 , 5-d] pyrimidin-7-amine Part A: The product of Part E (0.72 g) from Example 1 was dissolved in a mixture of ethanol (10 mL) and triethylamine (0.21 g) and added 2 -amino- 1- methoxybutane (0.23 g) . The reaction mixture was refluxed for 8 h, removed the solvent, partitioned between ethyl acetate (25 mL) and water (25 mL) , washed the organic layer with brine, dried and stripped down to a residue. The residue was purified by flash column chromatography (1:100 MeOH + CH2CI2) to afford ( + /- ) -3- [2-bromo-4- (1-methyl ethyl) phenyl] -N- [1- ( l-methoxymethyl)propyl]-5-methyl-3H- 1,2,3 - triazolo [4, 5-d] pyrimidin- 7-amine as a white solid (mp 132-134 °C) . Elemental analysis for CigH25Br 60: Theory C: 52.66, H: 5.81, N: 19.39. Found: C: 52.52, H: 5.72, N: 19.46. Part B: The product of Part A from Example 9 was rearranged in a manner similar to Part G of Example 1 to furnish the title compound as a white crystalline solid (mp 115-116 °C) . Elemental analysis for Cl9H25BrN6θ: Theory C: 52.66, H: 5.81, N: 19.39. Found: C: 52.61, H: 5.70, N: 19.41. Example 10 (+/- ) -N- [2-bromo-4- ( 1-methylethyl ) phenyl ] -N- ethyl-3- [1- (l-methoxymethyl)propyl] -5-methyl- 3H-1, 2, 3-triazolo [4, 5-d] pyrimidin-7-amine Using the procedure for Example 2, the product of Part B in Example 9 was alkylated to afford the title compound as a colorless oil. Elemental analysis for C2lH29BrN6θ: Theory C: 54.66, H: 6.35, N: 18.21. Found: C: 54.76, H: 6.86, N: 17.85. Example 11 (S) -N- [2-bromo-4- (1-methylethyl) phenyl] -3- [1- ( 1-methoxymethyl) -2-phenylethyl] - 5 -methyl -3 - 1, 2, 3-triazolo[4, 5-d] pyrimidin-7-amine Part A: The product of Part E from Example 1 was treated with S- (+) -2-amino-l-methoxy-3- phenylpropane hydrochloride in the same manner as outlined in Part A of Example 9 to afford (S)-3-[2- bromo-4- (1-methylethyl) phenyl] -N- [1- (1-methoxymethyl) - 2-phenylethyl] - 5 -methyl -3H-1, 2 , 3-triazolo[4, 5- d]pyrimidin-7-amine as a white solid (mp 67-69 °C) . Elemental analysis for C24H27BrΝ6θ: Theory C: 58.18, H: 5.49, N: 16.96. Found: C: 57.79, H: 5.39, N: 16.77. Part B: The product of Part A from Example 11 was rearranged in the same way as outlined in Part G of Example 1 to furnish the title compound as a colorless oil. Elemental analysis for C24H27BrN θ: Theory C: 58.18, H: 5.49, N: 16.96. Found: C: 57.94, H: 5.49, N: 16.43. Example 12 (S) -methyl 7- [2-bromo-4- ( 1-methylethyl) phenyl] - 5-methyl-a- [2- (methylthio) ethyl] -3H-1, 2, 3- triazolo [4, 5-d] pyrimidine-3-acetate Part A: The product of Part E from Example 1 was treated with L-methionine methyl ester hydrochloride in the same manner as outlined in Part A of Example 9 to afford (S) -methyl 3- [2-bromo-4- (1- methylethyl) phenyl] -5-methyl-a- [2- (methylthio) ethyl] - 3H-1,2, 3 -triazolo [4, 5-d] pyrimidine-7-acetate as a white solid (mp 135-137 °C) . Elemental analysis for C2θH25Br 6θ2S: Theory C: 48.68, H: 5.12, N: 17.03. Found: C: 48.73,- H: 5.21, N: 16.90. Part B: The product of Part A from Example 12 was rearranged in the same way as described in Part G of Example 1 to furnish the title compound as a colorless oil. Elemental analysis for C2θH25Br 6θ2S: Theory C: 48.68, H: 5.12, N: 17.03. Found: C: 48.55, H: 5.19, N: 16.82. Example 13 (+/-)-#- [2-bromo-4- ( 1-methylethyl )phenyl] -3- [1- ethylpentyl] -5-methyl-3Jϊ-l, 2 , 3-triazolo [4, 5-d] pyri idin-7-amine Part A: The product of Part E from Example 1 was reacted with 3-aminoheptane in the same way as outlined in Part F to yield 3- [2-bromo-4- (1- methylethyl)phenyl] -N- [1-ethylpentyl] -5-methyl-3H- 1,2,3-triazolo[4, 5-d]pyrimidin-7-amine as a white crystalline solid (mp 137-138 °C) . Elemental analysis for C2lH29Br 6: Theory C: 56.63, H: 6.56, N: 18.87. Found: C: 56.53, H: 6.54, N: 18.79. Part B: Using the procedure for Part G in Example 1, the product of Part A in Example 13 was rearranged to yield the title compound as a colorless oil. Elemental analysis for C2lH29Br 6: Theory C: 56.63, H: 6.56, N: 18.87. Found: C: 56.78, H: 6.58, N: 18.79. Example 14 (+/- ) -N- [2-bromo-4- ( 1-methylethyl )phenyl] - N- ethyl-3- [1-ethylpentyl] -5-methyl-3H-l, 2 , 3- triazol [4, 5-d]pyrimidin-7-amine Using the procedure for Example 2, the product of Part B in Example 13 was alkylated to furnish the title compound as a colorless oil. Mass spec. (ESI): 473.4 Example 15 N- [2-bromo-4- (1-methylethyl)phenyl] -3- [1- propylbutyl] -5-methyl-3H-l,2,3-triazolo[4,5- d]pyrimidin-7-amine Part A: The product of Part E from Example 1 was reacted with 4-aminoheptane in the same manner as outlined in Part A of Example 9 to yield 3- [2-bromo-4- (1-methylethyl) henyl] -N-[1-propylbutyl]-5-methyl-SH¬ 1,2,3-triazolo[4,5-d]pyrimidin-7-amine as a white crystalline solid (mp 162-163 °C) . Elemental analysis for C2lH29BrΝ6: Theory C: 56.63, H: 6.56, N: 18.87. Found: C: 56.64, H: 6.56, N: 18.81. Part B: Using the procedure for Part G in Example 1, the product of Part A in Example 15 was rearranged to yield the title compound as a white crystalline solid (mp 69-70 °C) . Elemental analysis for C2lH29BrN6: Theory C: 56.63, H: 6.56, N: 18.87. Found: C: 56.69, H: 6.48, N: 18.97. Example 16 N- [ 2 -bromo-4 - ( 1-methylethyl ) phenyl ] - 3 - [ 1- butylpentyl ] - 5-methyl-3H- 1 , 2 , 3 -triazolo [4 , 5-d] pyrimidin- 7 -amine Part A: The product of Part E from Example 1 was reacted with 5-aminononane in a manner similar to Part A of Example 9 to yield 3- [2-bromo-4- ( 1- methylethyl ) phenyl] -N- [1-butylpentyl ] -5-methyl-3H- 1 , 2 , 3 -triazolo [4 , 5-d] pyrimidin-7-amine as a white crystalline solid (mp 132-133 °C ) . Elemental analysis for C23H33Br 6: Theory C: 58.35, H: 7.04, N: 17.75. Found: C: 58.19,- H: 7.00, N: 17.97. Part B: Using the procedure for Part G in Example 1, the product of Part A in Example 16 was rearranged to yield the title compound as a colorless oil. Elemental analysis for C23H33Br 6: Theory C: 58.35, H: 7.04, N: 17.75. Found: C: 58.58, H: 7.12, N: 17.47. Example 17 (+/- ) -N- [2-bromo-4- ( 1-methylethyl )phenyl] -3- [1- ethylbutyl] -5-methyl-3JT-l, 2, 3 -triazolo [4 , 5-d] pyrimidin-7-amine Part A: The product of Part E from Example 1 was reacted with 3-aminohexane in a manner similar to Part A of Example 9 to yield 3- [2-bromo-4- (1- methylethyl) phenyl] -N- [1 -ethyl utyl] -5-methyl-3H- 1, 2 , 3-triazolo[4, 5-d]pyrimidin-7-amine as a white crystalline solid (mp 154-155 °C) . Elemental analysis for C20H27BrN6: Theory C: 55.69, H: 6.32, N: 19.48. Found: C: 55.57, H: 6.31, N: 19.41. Part B: Using the procedure for Part G in Example 1, the product of Part A in Example 17 was rearranged to yield the title compound as a white crystalline solid (87-88 °C) . Elemental analysis for C20H27Br 6: Theory C: 55.69, H: 6.32, N: 19.48. Found: C: 55.70, H: 6.36, N: 19.40. Example 18 (+/-)-7- [2-bromo-4- ( 1-methylethyl)phenyl] -5- methyl-a-propyl-3H-1,2,3-triazolo[4, 5- d]pyrimidine-3-ethanol Part A: The product of Part E from Example 1 was treated with. DL-2-amino-l-pentanol in a manner similar to Part A of Example 9 to furnish 3-[2-bromo- 4- (1-methylethyl)phenyl] -5-methyl-a-propyl-3tf-l,2,3- triazolo[4, 5-d] yri idine-7-ethanol as a white crystalline solid (mp 154-155 °C) . Elemental analysis for Ci9H25BrN6θ: Theory C: 52.66, H: 5.83, N: 19.39. Found: C: 52.54, H: 5.64, N: 19.12. Part B: Using the procedure for Part G in Example 1, the product of Part A in Examplelδ was rearranged to afford the title compound as a colorless oil. Elemental analysis for Ci9H25BrN6θ: Theory C: 52.66, H: 5.83, N: 19.39. Found: C: 52.46, H: 5.83, N: 19.18. Example 19 N- [2-bromo-4- ( 1-methylethyl ) phenyl] -3- [1- ethylpropyl] -5-methyl-3JΪ-l, 2 , 3-triazolo[4,5- d]pyrimidin-7-amine Part A: The product of Part E from Example 1 was reacted with 3-aminopentane in the same manner as outlined in Part A of Example 9 to yield 3- [2-bromo-4- (1-methylethyl) phenyl] -N- [1-ethylpropyl] -5 -methyl -3H- 1, 2, 3-triazolo [4, 5-d]pyrimidin-7-amine as a white crystalline solid (mp 171-172 °C) . Elemental analysis for Cl9H25Br 6: Theory C: 54.68, H: 6.05, N: 20.14. Found: C: 54.54, H: 5.73, N: 20.18. Part B: Using the procedure for Part G in Example 1, the product of Part A in Example 19 was rearranged to yield the title compound as a white crystalline solid (mp 117-118 °C) . Elemental analysis for C2lH29BrN6: Theory C: 56.63, H: 6.56, N: 18.87. Found: C: 54.86, H: 5.93, N: 20.17. Example 20 N- [2 -bromo-4- ( 1-methylethyl ) phenyl ] -iV- ethyl -3 - [ 1-ethylpropyl ] - 5-methyl -3ff- l , 2 , 3 -triazolo [ 4 , 5- d] pyrimidin-7 -amine Using the procedure for Example 2, the product of Part B in Example 19 was alkylated to afford the title compound as a colorless oil. Elemental analysis for C2lH29BrN6: Theory C: 56.63, H: 6.56, N: 18.87. Found: C: 56.63, H: 6.33, N: 18.78. Example 21 N- (2-bromo-4, 6-dimethylphenyl)-5-methyl-3- [1- propylbutyl] -3JΪ-l,2,3-triazolo[4, 5-d] yrimidin- 7-amine Part A: The product of Part D (9 g) from Example 1 was dissolved in ethanol (100 mL) and N,N- diisopropylethylamine (8 g) . To this mixture 4- aminoheptane (7.65 g) was added and refluxed for 7 days. The ethanol was stripped off in vacuum, the residue was partitioned between ethyl acetate (250 mL) and water (150 mL) . The ethyl acetate layer was washed with brine (100 mL) , dried and stripped in vacuum to a pale yellow solid. Recrystallized from 2- propanol (20 mL) to yield 5-amino-4-chloro-6- (4- heptyl)amino-2-methylpyrimidine as a white crystalline solid (12.5 g; mpl62-163 °C) . Elemental analysis for C12H21CIN4: Theory C: 56.13, H: 8.24, N: 21.82. Found: C: 55.94 , H: 8.22, N: 21.78. Part B: Using the procedure for Part E in Example 1, the product of Part A in Example 21 was cyclized to yield 7-chloro-5-methyl-3- [1-propylbutyl]- 3H-l,2,3-triazolo[4, 5-d]pyri idine as a pale yellow solid (mp 92-93 °C) . Elemental analysis for C12HI8CIN5: Theory C: 53.83, H: 6.79, N: 26.16. Found: C: 53.81,' H: 6.60, N: 25.98. Part C : The product of Part B (0.27 g) from above was combined with 4-bromo-2,6-dimethylaniline (0.2 g) and heated at 150 °C for 4h. The reaction mixture was partitioned between dichloromethane (20 mL) and water (20 mL) , washed the organic layer with water, dried and stripped in vacuum to a residue. The residue was purified by flash column chromatography (1:100 MeOH + CH2CI2) to afford the title compound as an off-white solid (0.26 g; mp 141- 142 °C) . Elemental analysis for C2θH27BrN : Theory C: 55.69, H: 6.32, N: 19.48. Found: C: 56.05 , H: 6.26, N: 19.71. Example 22 5-methyl-N- [4- ( 1-methylethyl ) -2- ( ethylthio)phenyl] -3- [1-propylbutyl ] -3H-1, 2, 3- triazolo[4,5-d] pyr imi din- 7 -amine The product of Part B from Example 21 was treated with 4-isopropyl-2-methylthioaniline in a manner similar to Part C in Example 21, to yield the title compound as a pale yellow oil. Elemental analysis for C22H32N6S: Theory C: 64.04, H: 7.83, N: 20.37. Found: C: 64.12, H: 7.54, N: 20.41. Example 23 N- [2-bromo-4- (trif luromethyl ) phenyl ) ] -5-methyl- 3- [l-propylbutyl]-3iT-l,2, 3 -triazolo [4 , 5- d] pyr imi din- 7 -amine The product of Part B from Example 21 was combined with 2-bromo-4-trif luromethylaniline in a manner similar to Part C in Example 21, to yield the title compound as a white crystalline solid (mp 84-85 °C) . Elemental analysis for Ci9H22BrF3Ng: Theory C: 48.42, H: 4.70, N: 17.83. Found: C: 48.58, H: 4.50, N: 17.78. Example 24 N- [2-bromo-4, 6- ( dime t ho xy) phenyl ) ] - 5 -methyl- 3- [l-propylbutyl]-3tf- 1,2, 3 -triazolo [4, 5- d] pyr imi din- 7 -amine The product of Part B from Example 21 was combined with 2-bromo-4, 6-dimethoxyaniline in a manner similar to Part C in Example 21, to yield the title compound as a white crystalline solid (mp 146-147 °C) . Elemental analysis for C2θH27BrN6θ2 : Theory C: 51.84, H: 5.87, N: 18.14. Found: C: 51.95, H: 5.68, N: 18.15. Example 25 N- [2, 6-dimethyl-4- (methylthio) phenyl) ] -5- methyl- 3- [ 1-propylbutyl] -3 -1, 2, 3 -triazolo [4, 5- d] pyr imi din- 7 -amine The product of Part B from Example 21 was combined with 2, 6-dimethyl-4-methylthioaniline in a manner similar to Part C in Example 21, to yield the title compound as a cream colored solid (mp 139-140 °C) . Elemental analysis for C21H30N S: Theory C: 63.28, H: 7.60, N: 21.09. Found: C: 62.98 , H: 7.32, N: 21.38. Example 26 N- (4-acetyl-2-bromophenyl ) -3- [ 1-ethylpropyl] -5 methyl -3H-1, 2,3-triazolo[4, 5-d] pyr imi din- 7- amine Part A: The product of Part D from Example 1 was treated with 3-aminopentane in a manner similar to Part A of Example 21, to yield 5-amino-4-chloro-2- methyl-6-(3-pentyl)aminopyrimidine as a white crystalline solid (mp 155-156 °C) . Elemental analysis for C10H17CIN4: Theory C: 52.51, H: 7.49, N: 24.50. Found: C: 52.43, H: 7.31, N: 24.59. Part B: The product of Part A from above was cyclized in a manner similar to Part E of Example 1 to yield 7-chloro-5-methyl-3H-l,2,3-triazolo[4,5- d]pyri idine as a white crystalline solid (mp 96-97 °C) . Elemental analysis for C10H14CIN5: Theory C: 50.11, H: 5.90, N: 29.22. Found: C: 50.40, H: 5.78, N: 29.53. Part C: The product of Part B from above was combined with 4-acetyl-2-bromoaniline in a manner similar to Part C in Example 21, to yield the title compound as a pale yellow solid (mp 153-154 °C) . Elemental analysis for Ci8H2 l BrN6θ: Theory C: 51.81, H: 5.07, N: 20.14. Found: C: 51.86, H: 5.87, N: 19.84. Example 27 (+/-) -N- (4-acetyl-2-bromophenyl) -3- [1- ( 1- ethoxymethyDpropyl] -5-methyl-3H-l, 2, 3- triazolo[4,5-d] pyrimidin-7-amine Part A: The product of Part D from Example 1 was treated with 2-amino-l-methoxybutane in a manner similar to Part A of Example 21, to yield 5-amino-4- chloro-6- (l-methoxy-2-butyl) amino-2-methylpyrimidine as an orange yellow solid (mp 128-130 °C) . Part B: The product of Part A from above was cyclized in a manner similar to Part E of Example 1 to yield 7-chloro-3- [1- (1 -methoxymethyDpropyl] - 5 -me hyl - 3H-1, 2, 3 -triazolo [4, 5-d] pyrimidine as an off-white crystalline solid (mp 66-87 °C) . Elemental analysis for C10H14CIN5O: Theory C: 46.97, H: 5.53, N: 27.39. Found: C: 47.22 , H: 5.43, N: 27.47. Part C: The product of Part B from above was combined with 4-acetyl-2-bromoaniline in a manner similar to Part C in Example 21, to yield the title compound as a pale yellow solid (mp 133-134 °C) . Elemental analysis for Ci8H2lBrN6θ2: Theory C: 49.89, H: 4.90. Found: C: 50.13, H: 4.99. Example 28 (+/-)-N- (4-bromo-2, 6-dimethylphenyl ) -3- [1- (1- methoxymethyDpropyl] - 5 -methyl- 3 H- 1, 2,3- triazolo[4, 5-d]pyrimidin-7-amine The product of Part B from Example 27 was combined with 4-bromo-2, 6-dimethylaniline in a manner similar to Part C in Example 21, to yield the title compound as a white crystalline solid (mp 137-138 °C) . Elemental analysis for Ci8H23Br 6θ2: Theory C: 51.56, H: 5.54, N: 20.04. Found: C: 51.75, H: 5.43, N: 19.99. Example 29 (+/- ) -N- [2, 6-dimethyl-4- (methylthio) phenyl] -3- [1- (l-methoxymethyl)propyl] -5 -methyl -3H-1, 2,3- triazolo [4, 5-d]pyrimidin-7-amine The product of Part B from Example 27 was combined with 2, 6-dimethyl-4-methylthioaniline in a manner similar to Part C in Example 21, to yield the title compound as a white crystalline solid (mp 128- 129 °C) . Elemental analysis for Ci9H26BrNgOS: Theory C: 59.04, H: 6.78. Found: C: 58.49, H: 6.48. Example 30 (+/-) -N-(2-bromo-4, 6-dimethoxyphenyl) -3- [1- (1- methoxymethyl)propyl] -5-methyl-3Jϊ-1,2,3- triazolo[4,5-d]pyrimidin-7-amine The product of Part B from Example 27 was treated with 2-bromo-4, 6-dimethoxyaniline in a manner similar to Part C in Example 21, to yield the title compound as a white crystalline solid (mp 154-155 °C) . Elemental analysis for CιsH23BrN θ3 : Theory C: 47.90, H: 5.14, N: 18.62. Found: C: 48.28 , H: 5.20, N: 18.91. Example 31 (+/-) -N-(2-chloro-4, 6 -dimethoxyphenyl) -3- [1- (1- methoxymethyDpropyl] -5-methyl-3.ff- 1, 2,3- triazolo[4, 5-d]pyrimidin-7-amine The product of Part B from Example 27 was treated with 2-chloro-4, 6-dimethoxyaniline in a manner similar to Part C in Example 21, to yield the title compound as a white crystalline solid (mp 149-150 °C) . Elemental analysis for C18H23CIN6O3: Theory C: 53.14, H: 5.70 N: 20.66. Found: C: 53.36, H: 5.72, N: 20.49. Example 32 (+/- ) -3- [1- ( 1-methoxymethyl) propyl] -5-methyl- tf-(2,4, 6-trimethylphenyl)-3iV-l,2, 3- triazolo [4, 5-d]pyrimidin-7-amine Part A: 4 , 6-Dichloro-2-methyl-5- nitropyrimidine (10 g, 48 mmol) dissolved in DMSO / water (480 ml / 48 ml) followed by addition of 2,4,6- trimethylaniline (7.43 ml, 52.8 mmol) dropwise via syringe over 30 minutes. The reaction was stirred at room temperature for 18 h and filtered. The solid was washed with water until the filtrant volume reached 600 ml. A 150 ml aliquat was removed, diluted with 1.5 liters water; 100 ml saturated brine, and extracted with 4 X 100 ml methylene chloride. This procedure was repeated until the remainder of the filtrant had been worked up. The combined organic extracts were dried over anhydrous magnesium sulfate, filtered and concentrated in-vacuo. The crude solid was chromatographed on silica gel (350 g, 97/3 methylene chloride / methanol) to give the desired yellow crystalline product, 10.53 g (76%). ^K NMR (CDCI3, 300 MHz) d 12.23 (bs, IH) , 10.60 (s, IH) , 6.95 (S, 2H) , 2.34 ( 2, 3H), 2.33 (s, 3H) , 2.16 (s, 6H) Part B: The product from Part A (3.1 g, 11 mmol) was suspended in phosphorous oxychloride (25 ml) and heated to just under reflux for 1 h, to give a dark homogeneous reaction. The reaction was pipetted slowly and cautiously onto 700 ml ice/water, stirred 30 minutes at room temperature, diluted with 200 ml methylene chloride and transferred to a separatory funnel. The aqueous layer was extracted and reextracted with 3 X 50 ml methylene chloride. The combined organic extracts were dried over anhydrous magnesium sulfate, filtered and concentrated in-vacuo to constant weight to afford 3.18 g (97%) of the product as a bright yellow solid. !H NMR (CDCI3, 300 MHz) d 8.79 (bs, IH) , 6.96 (s, 2H) , 2.42 (s, 3H) , 2.33 (S, 3H) , 2.15 (S, 6H) . Part C: The product from Part B (2.73 g, 8.9 mmol) was suspended in 60 ml methanol, followed by addition of acetic acid (3.4 ml), cooling to 0 C in an ice/acetone bath, and addition of iron (1.84 g) . The heterogeneous reaction was stirred 5 minutes at 0 °C, then refluxed 3 h, cooled, and filtered through celite. The celite pad was washed with 500 ml ethyl acetate. The dark filtrate was concentrated in-vacuo to near dryness, redissolved in ethyl acetate / water and extracted. The aqueous layer was reextracted several times with ethyl acetate. The combined organic extracts were dried over anhydrous magnesium sulfate, filtered and concentrated in-vacuo . Chromatography on silica gel (300 g, 1/1 ethyl acetate / hexanes) gave the product 2.18 g (88%) as an off- white solid. λ U NMR (CDCI3, 300 MHz) d 6.93 (s, 2H) , 6.25 (bs, IH), 3.13 (bs, 2H) , 2.36 (s, 3H) , 2.31 (s, 3H), 2.17 (s, 6H) . Part D: The product from Part C (1.28 g, 4.60 mmol) was dissolved in methylene chloride (20 ml), followed by addition of 50% aq. acetic acid (14 ml) and sodium nitrite (338 mg, 4.89 mmol) in water (1ml) . The reaction was stirred for 3 hours at room temperature, transferred to a separatory funnel, diluted with 100 ml water and 30 ml methylene chloride and extracted. The aqueous layer was reextracted with 3X30 ml methylene chloride. The combined organic layers were washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo . Chromatography on silica gel (200 g, 2/8 ethyl acetate / hexanes) gave the product 1.32 g (88%) as an off- white crystalline solid, mp 186-188 °C. CI-HRMS calcd. for C14H15N5CI1 (M+H) : 288.1016. Found: 288.1008. Part E: The product from Part D (425 mg, 1.48 mmol) was treated with triethylamine (0.247 ml, 1.78 mmol) and 2-amino-l-methoxy butane (0.183 ml, 1.78 mmol) in ethanol (10 ml) at reflux for 2 h. The reaction was concentrated directly to dryness in vacuo . Chromatography on silica gel (150 g, 1/2 hexanes / ethyl acetate) afforded the purified product, 392 mg (75%) as a crystalline solid, mp 156- 157.5 °C. Anal. Calcd. for C19H26N6O1: C, 64.38; H, 7 . 39 ; N, 23 . 71 . Found: C , 64 . 27 ; H, 7 . 47 ; N, 23 . 62 . Part P: The product from Part E (250 g, 0.70 mmol) was treated with sodium hydride (42 mg, 1.40 mmol, 80%) in dry dimethylformamide (5 ml) . The reaction was stirred 72 hours at room temperature, and 24 h at 50 C, followed by dilution with 100 ml water and extraction with 3X30 ml ethyl acetate. The combined organics were dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness. Chromatography on silica gel (50 g, 1/2 hexanes / ethyl acetate) afforded the purified product, 239 mg (96%) as a crystalline solid, mp 144.5-147 °C . Anal. Calcd. for C19H26N6O1: C, 64.38; H, 7.39; N, 23.71. Found: C, 64.32; H, 7.33; N, 23.78. Example 33 (+/-)-W-ethyl-3- [1- (l-methoxy-methyl)propyl] -5- methyl-N- (2,4,6-trimethylphenyl)-3H-1,2, 3- triazolo[4, 5-d]pyrimidin-7-amine The product from Example 32, Part F (125 mg, 0.35 mmol) was treated with sodium hydride (13 mg, 0.42 mmol, 80%) and ethyl iodide (42 ml, 0.42 mmol) in dry dimethylformamide (3 ml) and stirred at room temperature for 48 h. The reaction was diluted with 50 ml water, and extracted with 4X30 ml methylene chloride. The combined organic extracts were dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo to dryness. Chromatography on silica gel (50 g, 3/2 hexanes / ethyl acetate) afforded the desired product, 111 mg (80%) as a clear viscous oil. CI-HRMS calcd. for C21H31 6O1 (M+H) : 383.2559. Found: 383.2567. Example 34 3- [l-(l-ethyl)propyl] -5 -methyl -N- (2,4,6- trimethylphenyl) -3H-1, 2, 3-triazolo [4, 5-d] pyrimidin-7-amine Part A: The product from Example 32, Part D (500 mg, 1.74 mmol) was treated with triethylamine (0.29 ml, 2.09 mmol) and 3-ammopentane (0.243 ml, 2.09 mmol) in ethanol (10 ml) at reflux for 2 h. The reaction was concentrated directly to dryness in vacuo. Chromatography on silica gel (100 g, 8/2 hexanes / ethyl acetate) afforded the purified product, 462 mg (79%) as a crystalline solid, mp 184.5-186.5 °C. Anal. Calcd. for C19H26N6: C, 67.43; H, 7.74; N, 24.83. Found: C, 67.11; H, 7.59; N, 24.57. Part B: The product from Part A (300 mg, 0.89 mmol) was treated with sodium hydride (53 mg, 1.78 mmol, 80%) in dry dimethylformamide (5 ml) . The reaction was stirred 72 hours at 50 C, followed by dilution with 125 ml water and extraction with 3X40 ml ethyl acetate. The combined organics were dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness. Chromatography on silica gel (75 g, 8/2 hexanes / ethyl acetate) afforded the purified product, 239 mg (80%) as a crystalline solid, mp 160-162 °C. Anal. Calcd. for C19H26N6: C, 67.43; H, 7.74; N, 24.83. Found: C, 67.07; H, 7.85; N, 24.51. Example 35 (+/-)-3- [1-(1- ethyl) butyl ] -5-methyl-N- (2,4,6- trimethylphenyl) -3H-1, 2, 3 -triazolo [4, 5-d] pyr imi din- 7 - amine Part A: The product from Example 32, Part D (525 mg, 1.82 mmol) was treated with triethylamine (0.305 ml, 3.64 mmol) and 3-aminohexane (0.219 ml, 3.64 mmol) in ethanol (8 ml) at 50°C for 18 hours. The reaction was concentrated directly to dryness in vacuo. Chromatography on silica gel (140 g, 8/2 hexanes / ethyl acetate) afforded the purified product, 450 mg (70%) as a crystalline solid, mp 170.5-172 °C. Anal. Calcd. for C20H28 6: C, 68.15; H, 8.02; N, 23.84. Found: C, 68.10; H, 7.80; N, 23.94. Part B: The product from Part A (300 mg, 0.85 mmol) was treated with sodium hydride (64 mg, 2.13 mmol, 80%) in dry dimethylformamide (5 ml) . The reaction was stirred 24 hours at room temperature, and 24 hours at 50 °C, followed by dilution with 125 ml water and extraction with 4X30 ml ethyl acetate. The combined organics were dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness. Chromatography on silica gel (60 g, 8/2 hexanes / ethyl acetate) afforded the purified product, 266 mg (89%) as a crystalline solid, mp 156-157.5 °C. Anal. Calcd. for C19H26N6: C, 68.15; H, 8.01; N, 23.84. Found: C, 68.51; H, 8.10; N, 23.94. Example 36 (+/-)-3- [l-(l-ethyl)pentyl] -5-methyl -N- (2,4,6- trimethylphenyl) -3ff-l,2,3-triazolo[4,5-d] pyrimidine-7-amine Part A: The product from Example 32, Part D (500 mg, 1.74 mmol) was treated with triethylamine (0.290 ml, 4.35 mmol) and 3-aminoheptane (0.343 ml, 4.35 mmol) in ethanol (8 ml) at 50 °C for 18 h. The reaction was concentrated directly to dryness in vacuo. Chromatography on silica gel (125 g, 8/2 hexanes / ethyl acetate) afforded the purified product, 465 mg (73%) as a crystalline solid, mp o. 141.5-142.5 C. Anal. Calcd. for C21H30N6: C, 68.82; H, 8.25; N, . 22.93. Found: C, 69.11; H, 8.10; N, 23.04. Part B: The product from Part A (300 mg, 0.82 mmol) was treated with sodium hydride (49 mg, 1.64 mmol, 80%) in dry dimethylformamide (5 ml) . The reaction was stirred 24 hours at 50°C, followed by dilution with 125 ml water and extraction with 4X30 ml ethyl acetate. The combined organics were dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness. Chromatography on silica gel (75 g, 8/2 hexanes / ethyl acetate) afforded the purified product, 236 mg (79%) as a crystalline solid, mp 129-130.5 °C. Anal. Calcd. for C21H30N6: C, 68.82; H, 8.25; N, 22.93. Found: C, 68.73; H, 8.23; N, 22.90. Example 37 5-methyl-3- [1- (1-propyl)butyl] -N- (2,4, 6- trimethylphenyl) -3H-l,2,3-triazolo[4,5-d] pyrimidin-7-amine Part A: The product from Example 32, Part D (255 mg, 0.87 mmol) was treated with triethylamine (0.145 ml, 1.74 mmol) and 4-aminoheptane (0.120 ml, 1.74 mmol) in ethanol (5 ml) at 50°C for 18 hours. The reaction was concentrated directly to dryness in vacuo . Chromatography on silica gel (60 g, 8/2 hexanes / ethyl acetate) afforded the purified product, 233 mg (73%) as a crystalline solid, mp 145- 146.5 °C. Anal. Calcd. for C21H30N6: C, 68.82; H, 8.25; N, 22.93. Found: C, 69.09; H, 8.21; N, 23.04. Part B: The product from Part A (230 mg, 0.63 mmol) was treated with sodium hydride (47 mg, 1.58 mmol, 80%) in dry dimethylformamide (5 ml) . The reaction was. stirred 24 hours at room temperature, and 24 h at 50 °C, followed by dilution with 125 ml water and extraction with 4X30 ml ethyl acetate. The combined organics were dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness. Chromatography on silica gel (60 g, 8/2 hexanes / ethyl acetate) afforded the purified product, 211 mg (92%) as a crystalline solid, mp 143-144.5 °C . Anal. Calcd. for C21H30N6: C, 68.82; H, 8.25; N, 22.93. Found: C, 69.08; H, 8.10; N, 23.03. Example 38 3- (2-methoxyethyl) -5-methyl -N- (2,4,6- trimethylphenyl) -3Jϊ-l,2,3-triazolo[4,5- d]pyrimidin-7-amine Part A: The product from Example 32, Part D (1.07 g, 3.70 mmol) was treated with triethylamine (0.620 ml, 4.44 mmol) and 2-methoxyethylamine (0.386 ml, 4.44 mmol) in ethanol (20 ml) at reflux for 3 h. The reaction was concentrated directly to dryness in vacuo . Chromatography on silica gel (150 g, 1/1 hexanes / ethyl acetate) afforded the purified product, 1.18 g (97%) as a crystalline solid, mp 141.5-143.5 °C. Anal. Calcd. for C17H22N6O1: C, 62.56; H, 6.79; N, 25.75. Found: C, 62.54; H, 6.78; N, 25.70. Part B: The product from Part A (325 mg, 1.00 mmol) was treated with sodium hydride (60 mg, 2.00 mmol, 80%) in dry dimethylformamide (5 ml) . The reaction was stirred 72 hours at room temperature, and 24 hours at 50 C, followed by dilution with 125 ml water and extraction with 4X30 ml ethyl acetate. The combined organics were dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness. Chromatography on silica gel (50 g, 1/2 hexanes / ethyl acetate) afforded the purified product, 321 mg (99%) as a crystalline solid, mp 171.5-173.5 °C. Anal. Calcd. for C17H22N6O1: C 62.56; H, 6.79. Found: C, 62.24; H, 6.89. Example 39 N-ethyl-3- (2-methoxyethyl)-5-methyl-N- (2,4, 6- trimethylphenyl) -3Jr-l,2,3-triazolo[4,5- d]pyrimidin-7-amine The product from Example 38, Part B (150 mg, 0.46 mmol) was treated with sodium hydride (17 mg, 0.55 mmol, 80%) and ethyl iodide (55 ml, 0.69 mmol) in dry dimethylformamide (3 ml) and stirred at room temperature for 48 h. The reaction was diluted with 50 ml water, and extracted with 4X30 ml methylene chloride. The combined organic extracts were dried over anydrous magnesium sulfate, filtered, and concentrated in vacuo to dryness. Chromatography on silica gel (50 g, 1/1 hexanes / ethyl acetate) afforded the desired product, 144 mg (88%) as a clear viscous oil. CI-HRMS calcd. for C19H27N6O1 (M+H) : 355.2246. Found: 355.2240. Example 40 N- (2-Methyl-4-bromophenyl) -3- [1- ( 1- propyl) butyl] -5-methyl-3iϊ-l, 2, 3 -triazolo [4, 5- d]pyrimidin-7-amine Part A: 4, 6-Dichloro-2-methyl-5- nitropyrimidine (5.2 g, 25 mmol) dissolved in DMSO (480 ml) followed by addition of 2-methyl-4- bromoaniline (4.65 g, 25 mmol) dropwise via syringe over 30 minutes. The reaction was stirred at RT for 18 h, followed by addition of 800 ml water. The resulting precipitate was filtered and dried to constant weight affording 7.02 g (83%) of the desired pyrimidone as a ' yellow solid. Part B: The product from Part A (6.95 g, 20.5 mmol) was treated with phosphorous oxychloride (120 ml) and brought to reflux for 20 minutes. The reaction was cooled, and slowly quenced on 3 L of ice/water. The resultant precipitate was filtered and dried. Chromatography on silica gel (500 g, 8/2 hexanes / ethyl acetate) gave the purified product, 5.4 g (74%) , as a yellow solid. Part C: The product from Part B (5.4 g, 15.2 mmol) was suspended in 120 ml methanol, followed by addition of acetic acid (6.8 ml) , cooling to 0 °C in an ice/acetone bath, and addition of iron (4.23 g) under the same conditions described in Example 32, Part C. The resultant brown solid was used directly in the next reaction. Part D: The product from Part C (15.2 mmol) was dissolved in methylene chloride (100 ml) , followed by addition of 50% aq. acetic acid (50 ml) and sodium nitrite (1.15 g, 16.70 mmol) in water (5ml) under the same conditions described in Example 32, Part D. Chromatography of the crude product on silica gel (400 g, 2/8 ethyl acetate / hexanes) gave the product 3.15 g (62% from Part C) as an off-white crystalline solid, mp 145-147.5 °C. Part E: The product from Part D (600 mg, 1.78 mmol) was treated with triethylamine (300 ml, 2.14 mmol) and 4-aminoheptane (246 ml, 2.14 mmol) in ethanol (10 ml) at 50 °C for 18 h. The reaction was concentrated directly to dryness in vacuo . Chromatography on silica gel (125 g, 8/2 hexanes / ethyl acetate) afforded the purified product, 600 mg o. (81%) as a crystalline solid, mp 155-156 C. Anal. Calcd. for Cl9H25N6Bri: C, 54.68; H, 6.05; N, 20.14. Found: C, 54.36; H, 5.71; N, 20.24. Part P: The product from Part E (350 mg, 0.84 mmol) was treated with sodium hydride (63 mg, 2.10 mmol, 80%) in dry dimethylformamide (5 ml) . The reaction was stirred 24 h at room temperature, and 24 h at 50 C, followed by dilution with 125 ml water and extraction with 4X30 ml ethyl acetate. The combined organics were dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness. Chromatography on silica gel (60 g, 8/2 hexanes / ethyl acetate) afforded the purified product, 333 mg (95%) as a crystalline solid, mp 126.5-128 °C. Anal. Calcd. for Cl9H25N6Bri: C, 54.68; H, 6.05; N, 20.14. Found: C, 54.90; H, 6.04; N, 20.40. Example 41 (+/-)-3- [1- (1-ethyl)butyl]-5-methyl- - (2- methyl-4-bromophenyl)-3Jϊ-l,2,3-triazolo[4,5- d]pyrimidin-7-amine Part A: The product from Example 40, Part D (600 mg, 1.78 mmol) was treated with triethylamine (0.300 ml, 2.14 mmol) and 3-aminohexane (0.214 ml, 2.14 mmol) in ethanol (10 ml) at 50 °C for 18 h. The reaction was concentrated directly to dryness in vacuo. Chromatography on silica gel (75 g, 8/2 hexanes / ethyl acetate) afforded the purified product, 616 mg (86%) as a crystalline solid, mp 117.5-119.5 °C. Anal. Calcd. for CιsH23 6Bri: C, 53.60; H, 5.76; N, 20.84. Found: C, 53.53; H, 5.72; N, 20.95. Part B: The product from Part A (450 mg, 1.12 mmol) was treated with sodium hydride (84 mg, 2.80 mmol, 80%) in dry dimethylformamide (10 ml). The reaction was stirred 72 hours at room temperature, followed by dilution with 125 ml water and extraction with 4X30 ml ethyl acetate. The combined organics were dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness. Chromatography on silica gel (75 g, 8/2 hexanes / ethyl acetate) afforded the purified product, 425 mg (94%) as a crystalline solid, mp 99-101 °C. Example 42 (+/- ) -N- (4-bromo-2-methylphenyl) -3- [1- (1- methoxymethyl) propyl]-5-methyl-3Jϊ-l,2,3- triazolo[4, 5-d]pyrimidin-7-amine Part A: The product from Example 40, Part D (800 mg, 2.37 mmol) was treated with triethylamine (0.400 ml, 2.84 mmol) and 2-amino-l-methoxybutane (0.341 ml, 2.84 mmol) in ethanol (20 ml) at room temperature for 48 h. The reaction was concentrated directly to dryness in vacuo. Chromatography on silica gel (150 g, 8/2 hexanes / ethyl acetate) afforded the purified product, 697 mg (72%) as a crystalline solid, mp 144.5-146 C. Anal. Calcd. for Ci7H2lNeBriOi: C, 50.38; H, 5.22; N, 20.74. Found: C, 50.35; H, 5.23; N, 20.58. Part B: The product from Part A (550 mg, 1.36 mmol) was treated with sodium hydride (102 mg, 3.40 mmol, 80%) in dry dimethylformamide (8 ml) . The reaction was stirred 72 h at room temperature, followed by dilution with 125 ml water and extraction with 4X30 ml ethyl acetate. The combined organics were dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness. Chromatography on silica gel (75 g, 8/2 hexanes / ethyl acetate) afforded the purified product, 520 mg (94%) as a crystalline solid. Example 43 (+/-)-3- [l-(lτethyl)pentyl] -5-methyl -N- [(2,4,6- trimethyl)-3-pyridyl-]-3Jϊ-l,2,3-triazolo[4, 5-d] pyrimidin-7-amine Part A: To 2 , 4-dichloro-2-methyl-5- nitropyrimidine (10.10 g, 48.60 mmol) in dry tetrahydrofuran (200 ml) and triethylamine (6.8 ml, 48.6 mmol) was added 3-amino-2, 4, 6-trimethylpyridine (3.30 g, 24.3 mmol) in tetrahydrofuran (30 ml) via canulation over 10 minutes at room temperature. The reaction was stirred 72 h, diluted with 1 L of water, and extracted with 4X200 ml ethyl acetate. The combined organic extracts were dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness in vacuo. Chromatography on silica gel (300 g, 1/1 ethyl acetate / hexanes) afforded the purified product, 4.8 g (64%) as a white solid. 1 H NMR (300 MHz, CDC13) d 8.79 (bs, IH) , 6.97 (s, IH) , 2.54 (s, 3H), 2.43 (s, 3H), 2.40 (s, 3H) , 2.17 (s, 3H) . Part B: The product from Part A (4.8 g, 15.60 mmol) was treated with iron (4.36 g, 78.00 mmol) in methanol (110 ml) and acetic acid (6 ml) under the same reaction conditions described in Example 32, Part C. Chromatography on silica gel (250 g, 9/1 methylene chloride / methanol) afforded the purified reduction product, 3.1 g, (72%) as a white solid. 1 H NMR (300 MHz, CDC13) d 6.94 (s, IH) , 6.26 (bs, IH) , 3.36 (bs, IH), 2.52 (s, 3H) , 2.41 (s, 3H) , 2.35 (s, 3H) , 2.16 (s, 3H) . Part C: The product from Part B (2.1 g, 7.56 mmol) was treated with sodium nitrite (574 mg, 8.32 mmol) in methylene chloride (44 ml) and 50% aq. acetic acid (25 ml) under the same reactions conditions described in Example 32, Part D. Chromatography on silica gel (125 g, 1/1 ethyl acetate / hexanes) afforded the purified cyclized product, 1.7 g (78%) as a white solid, mp 204.5-206°C. Anal. Calcd. for C13H13N6CI1: C, 54.08; H, 4.55; N, 29.11. Found: C, 53.94; H, 4. ' 43; N, 28.79. Part D: The product from Part C (300 mg, 1.04 mmol) was treated with triethylamine (175 ml, 1.25 mmol) and 3-aminoheptane (243 ml, 1.25 mmol) in ethanol (10 ml) at reflux for 2.5 hours. The reaction was concentrated directly to dryness in vacuo . Chromatography on silica gel (20 g, 1/2 hexanes / ethyl acetate) afforded the purified product, 356 mg (93%) as a crystalline solid, mp 122-130°C. Anal. Calcd. for C20H29 7: C, 65.37; H, 7.95; N, 26.68. Found: C, 65.35; H, 7.95; N, 26.82. Part E: The product from Part D (160 mg, 0.44 mmol) was treated with sodium hydride (27 mg, 0.88 mmol, 80%) in dry dimethylformamide (4 ml) . The reaction was stirred 24 hours at room temperature, and 100 hours at 50°C, followed by dilution with 100 ml water and extraction with 3X30 ml ethyl acetate. The combined organics were dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness. Preparative HPLC [(25-65%) acetonitrile : trifluoroacetic acid / water : trifluoroacetic acid, Dynamax C18 column] afforded the purified product, 60 mg (38%) as an amorphous foam. CI-HRMS calcd. for C20H29N7 (M+H) : 368.2545. Found: 368.2563. Example 44 (+/-)-W-ethyl-3- [l-(l-ethyl) pentyl] -5-methyl- N- t (2,4,6-trimethyl)-3-pyridyl-]- 3 -1,2,3- triazolo[4, 5-d]pyrimidin-7-amine The product from Example 43, Part E (29 mg, 0.08 mmol) was treated with sodium hydride (3 mg, 0.1 mmol, 80%) and ethyl iodide (9.6 ml, 0.12 mmol) in dry dimethylformamide (1 ml) and stirred at room temperature for 168 h. The reaction was diluted with 10 ml water, and extracted with 4X5 ml ethyl acetate. The combined organic extracts were dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo to dryness. Chromatography on silica gel (10 g, 1/1 hexanes / ethyl acetate) afforded the desired product, 19.7 mg (63%) as a clear viscous oil. CI-HRMS calcd. for C22H33N7 (M+H) : 396.2876. Found: 396.2876. Example 45 (+/-)-3- [1-(1-ethyl)butyl] -5-methyl-W- [(2,4,6- trimethyl)3-pyridyl-] - 3H-1,2,3-triazolo[4, 5- d]pyrimidin-7-amine Part A: The product from Example 43, Part C (546 mg, 1.89 mmol) was treated with triethylamine (0.316 ml, 2.27 mmol) and 3-aminohexane (0.210 mg, 2.07 mmol) in ethanol (15 ml) at reflux for 2.5 h. The reaction was concentrated directly to dryness in vacuo. Chromatography on silica gel (50 g, ethyl acetate) afforded the purified product, 530 mg (79%) as a crystalline solid, p 155.5-158 C. Anal. Calcd. for C19H27N7: C 64.56; H, 7.71; N, 27.74. Found: C, 64.59; H, 7.62; N, 27.91. Part B: The product from Part A (400 mg, 1.13 mmol) was treated with sodium hydride (94 mg, 3.11 mmol, 80%) in dry dimethylformamide (12 ml) . The reaction was stirred 72 h at 50 C, followed by dilution with 100 ml water and extraction with 4X30 ml ethyl acetate. The combined organics were dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness. Chromatography on silica gel (50 g, 1/3 hexanes / ethyl acetate) afforded the purified product, 355 mg (89%) as a crystalline solid, mp 132-140.5 °C. Anal. Calcd. for C19H27N7: C, 64.56; H, 7.71; N, 27.74. Found: C, 64.52; H, 7.58; N, 27.97. Example 46 N- ethyl - 3 - [1- (1-ethyl)butyl] -5-methyl-tf- [ (2,4,6-trimethyl)-3-pyridyl-] -3H-1,2,3- triazolo.4, 5-d]pyrimidin-7-amine The product from Example 45, Part B (250 mg, 0.71 mmol) was treated with sodium hydride (26 mg, 0.85 mmol, 80%) and ethyl iodide (0.85 ml, 1.07 mmol) in dry dimethylformamide (7 ml) and stirred at room temperature for 15 h. The reaction was diluted with 150 ml water, and extracted with 3X30 ml ethyl acetate. The combined organic extracts were dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo to dryness. Chromatography on silica gel (20 g, 1/3 hexanes / ethyl acetate) afforded the desired product, 221 mg (81%) as a clear viscous oil. Example 47 3- [1- (1-propyl)butyl] -5-methyl-W- [ (2,4, 6- trimethyl)-3-pyridyl-]-3H-l,2,3-triazolo[4, 5-d] pyrimidin-7-amine Part A: The product from Example 43, Part C (700 mg, 2.42 mmol) was treated with triethylamine (0.405 ml, 2.91 mmol) and 4-aminoheptane (335 mg, 2.91 mmol) in ethanol (20 ml) at reflux for 2.5 h. The reaction was concentrated directly to dryness in vacuo . Chromatography on silica gel (50 g, 1/3 hexanes / ethyl acetate) afforded the purified product, 845 mg (96%) as a crystalline solid, mp 135.5-137.5 °C. . Anal. Calcd. for C20H29N7: C, 65.37; H, 7.95; N, ' 26.68. Found: C, 65.71; H, 7.70; N, 26.95. Part B: The product from Part A (600 mg, 1.63 mmol) was treated with sodium hydride (147.5 mg, 4.89 mmol, 80%) in dry dimethylformamide (15ml). The reaction was stirred 15 h at 50 C, followed by dilution with 200 ml water and extraction with 5X30 ml ethyl acetate. The combined organics were dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness. Chromatography on silica gel (50 g, 1/3 hexanes / ethyl acetate) afforded the purified product, 560 mg (93%) as a crystalline solid, mp 128-130 °C. CI-HRMS calcd. for C20H29N7 (M+H) : 368.2561. Found: 368.2563. Example 48 tf-ethyl-3- [1- (1-propyl) butyl] -5-methyl-iy- [ (2,4,6-trimethyl)-3-pyridyl-] -3^-1,2, 3- triazolo [4, 5-d]pyrimidin-7-amine The product from Example 47, Part B (400 mg, 1.09 mmol) was treated with sodium hydride (40 mg, 1.31 mmol, 80%) and ethyl iodide (0.130 ml, 1.63 mmol) in dry dimethylformamide (10 ml) and stirred at room temperature for 15 hours. The reaction was diluted with 150 ml water, and extracted with 3X30 ml ethyl acetate. The combined organic extracts were dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo to dryness. Chromatography on silica gel (20 g, 1/3 hexanes / ethyl acetate) afforded the desired product, 373 mg (87%) as a clear viscous oil. Example 49 (+/-)-3-[l- (1-methoxymethyl) propyl] -5 -methyl - N- [ (2,4, 6-trimethyl)- 3-pyridyl- ] -3H- 1,2,3 - triazolo [4, 5-d]pyrimidin-7-amine Part A: The product from Example 43, Part C (700 mg, 2.42 mmol) was treated with triethylamine (0.405 ml, 2.91 mmol) and 2-aminomethoxybutane (0.350 ml, 2.91 mmol) in ethanol (20 ml) at reflux for 2.5 h. The reaction was concentrated directly to dryness in vacuo. Chromatography on silica gel (50 g, 1/1 hexanes / tetrahydrofuran) afforded the purified product, 845 mg (98%) as a crystalline solid, mp 132- 136.5 °C. Anal. Calcd. for C18H25N7O1: C, 60.82; H, 7.1; N, 27.58. Found: C, 61.13; H, 6.89; N, 27.54. Part B: The product from Part A (600 mg, 1.68 mmol) was treated with sodium hydride (151.2 mg, 5.04 mmol, 80%) in dry dimethylformamide (15ml) . The o reaction was stirred 15 hours at 50 C, followed by dilution with 100 ml water and extraction with 4X30 ml ethyl acetate. The combined organics were dried over anhydrous magnesium sulfate, filtered, and concentrated to dryness. Chromatography on silica gel (50 g, 1/1 hexanes / tetrahydrofuran) afforded the purified product, 500 mg (83%) as a crystalline solid, mp 141.5-144 °C. Anal. Calcd. for C18H25N7O1: C, 60.82; H, 7.1; N, 27.58. Found: C, 60.94; H, 6.95; N,27.46. Example 50 (+/-)-N-ethyl-3- [1- (1-methoxy methyl)propyl] -5- methyl- - [ (2, 4, 6-trimethyl) -3-pyridyl-] -3H- l,2,3-triazolo[4, 5-d]pyrimidin-7-amine The product from Example 49, Part B (350 mg, 0.99 mmol) was treated with sodium hydride (36 mg, 1.19 mmol, 80%) and ethyl iodide (0.119 ml, 1.49mmol) in dry dimethylformamide (10 ml) and stirred at room temperature for 15 h. The reaction was diluted with 150 ml water, and extracted with 3X30 ml ethyl acetate. The combined organic extracts were dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo to dryness. Chromatography on silica gel (20 g, 1/1 hexanes / tetrahydrofuran) afforded the desired product, 338 mg (89%) as a clear viscous oil. Example 51 N- (2,4-dibromophenyl)-5-methyl-3- (1- propyl)butyl - 3H- 1 , 2,3-triazolo[4, 5-d]pyrimidin- 7-amine Part A: 4-Aminoheptane (2.5 g) was added to a solution of 4, 6-ditosyloxy-2-methyl-5-nitropyrimidine (10.5 g) and N,N-diisopropylethylamine (3.8 mL) in dichloromethane (219 mL) . The reaction was stirred under nitrogen for 5 h at room temperature and then extracted with water. The organic layer was dried over anhydrous magnesium sulfate and concentrated to yield N- (l-propyl)butyl-2-methyl-5-nitro-4- tosyloxypyrimidin-6-amine as a pale yellow solid (9.1 g) Part B: The product of part A (9.0 g) , anhydrous toluene (200 mL) , Ν,Ν-diisopropylethylamine (3.8 mL) and 2,4-dibromoaniline (5.5 g) were heated at 65 °C for 16 h under nitrogen. The reaction was added to saturated aqueous NH4CI and extracted with dichloromethane (3 times) . The combined organic layers were dried over anhydrous magnesium sulfate and concentrated to yield N-4- (2,4-dibromophenyl) -N- [6- (1- propyl)butyl] -2-methyl-5-nitro-pyrimidin-4, 6-diamine as a yellow solid (6.5 g) . Part C: The product of part B (6.5 g), 1,4- dioxane (65 mL) , water (65 mL)., sodium dithionite (18.0 g) and 40% ammonium hydroxide (6.5 mL) were stirred for 3 h at room temperature. The reaction mixture was added to saturated aqueous NH4CI and extracted with ethyl acetate (3 times) . The combined organic layers were dried over anhydrous magnesium sulfate and concentrated. The residue was purified by flash column chromatography on silica gel using EtOAc/hexane (2:8) to yield N- [4- (2,4-dibromophenyl) ]- N- [6- (1-propyl)butyl]-2-methyl-5-aminopyrimidin-4,6- diamine as a pale yellow solid (5.1 g) . Part D: The product of part C (5.0 g) was dissolved in a 2:1:1 mixture of dichloromethane, acetic acid and water. To this solution was added sodium nitrite (0.9 g) and the resulting solution was stirred for 2 h at room temperature. The reaction was added to an equal volume of water and extracted with dichloromethane (3 times) . The combined organic layers were washed with saturated aqueous ΝaHCθ3, then were dried over anhydrous magnesium sulfate and concentrated. The residue was purified by flash column chromatography on silica gel using ethyl acetate/hexane (2:8) to yield N- (1-propyl)butyl-3- (2,4-dibromophenyl) -5-methyl-3H-l,2,3- triazolo[4,5-d] pyrimidin-7-amine as a white solid (3.9 g). A small amount of the title compound, N- (2,4-dibromophenyl) -5- methyl-3-(l-propyl)butyl-3H-l,2,3-triazolo[4,5- d]pyrimidin-7-amine (0.18 g) was also isolated from the chromatography. Part E: Sodium hydride (0.24 g) was added to a solution of the product of part D (3.9 g) in anhydrous DMF (82 mL) . The resulting solution was stirred for 16 h under nitrogen and the partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and concentrated. The resulting solid was recrystallized from boiling 2-propanol to afford the title compound as a white crystalline solid (3.6 g) . Example 52 N- [4-acetyl-2-bromophenyl]-5-methyl-3- (1- propyl)butyl-3H-l,2, 3-triazolo[4, 5-d]pyrimidin- 7-amine Bis(triphenylphosphine)palladium dichloride (11.9 mg) , tetrakis (triphenylphosphine) alladium (19.6 mg) and 1-ethoxyvinyltributyltin (299 mg) were added to the product of Part E, from Example 51 (0.33 g) dissolved in toluene (5 mL) . The reaction was heated to reflux and stirred overnight. The solvent was then removed under vacuum and the residue partitioned between ether and aqueous saturated NaF. The mixture was then filtered and separated. The organic layer was then washed with IN HCl, dried over anhydrous magnesium sulfate and concentrated. The residue was purified by flash column chromatography on silica gel using ethyl acetate/hexane (2:8) to yield the title compound. Example 53 N- [2-bromo-4- ( 1-methylethyl ) phenyl] -3- [1- (N,N- dimethylamino-methyl) butyl] -5-methyl-3J7-l, 2,3- triazolo [4 , 5-d] pyr imi din- 7 -amine Part A: A solution of N-CBZ-d, 1-norvaline (TCI America) in THF (0.5 M) is treated in sequence with 1-hydroxybenzotriazole hydrate (1.2 eq) , dimethylamine hydrochloride (1.3 eq) , triethylamine (1.4 eq) , and dicyclohexylcarbodiimide (1.2 eq) . After stirring overnight, the mixture is filtered, which is followed by aqueous workup and chromatography, to afford N,N-dimethyl-N'-CBZ-d, 1-norvalinamide, as an oil (TLC Rf = 0.10, 30:70 ethyl acetate-hexane) . Part B: A solution of the CBZ compound from Part A above is dissolved in methanol (1 M) , and 5% Pd on carbon is added. The mixture is submitted to hydrogenation in the usual Parr shaker apparatus (50 PΞI, overnight) . The resulting mixture is filtered through celite and evaporated to afford sufficiently pure product, N,N-dimethyl-d,1-norvalinamide, as an oil (TLC baseline in 30:70 ethyl acetate-hexane). Part C: The amine from Part B is elaborated to title compound by using the procedure outlined in Example 32 or 51. Spectral data. X H NMR (300 MHz, CDC13): d 8.61 (IH, d, J = 8.4 Hz), 8.20 (IH, br s), 7.48 (IH, d, J =1.8 Hz), 7.26 (IH, dd, J = 8.4, 1.8 Hz), 5.08-4.98 (IH, m) , 3.27 (IH, dd, J =12.6, 9.7 Hz), 2.91 (IH, heptet, J = 7.0 Hz), 2.68 (3H, s) , 2.67 (IH, dd, J =12.6 Hz), 2.22 (6H, s), 2.21-2.11 (IH, ) , 1.99-1.89 (IH, m) , 1.29-1.19 (IH, m) , 1.27 (6H, d, J = 7.0 Hz), 1.16-1.05 (IH, m) , 0.88 (3H, t, J = 7.1 Hz). MS(NH3-CI): m/e 464 (3), 463 (25), 462 (100), 461 (29), 460 (98). The compounds of Examples 54-208 can be made by the methods exemplified in Examples 1-53. Table 1 3H-1,2, 3-triazolo[4, 5-d]pyrimidines : S2- 2, 6- (Me)2-4-S0 2 Me-Ph CH(Et)Bu n H 2,6-(Me)2-4-SMe-Ph CH(Et)Bu n H 2,6-(Me)2-4-CF 3 -Ph CH(Et)Bu n H 2-Br-4,6-(Me)2"Ph CH(Et)Bu n H 4-Br-2-Me-Ph CH(Et)Bu n H 4-N(Et) 2 -2-Me-Ph CH(Et)Bu n H 4-I-2-Me-Ph CH(Et)Bu n H 2-I-4-i-Pr-Ph CH(Et)Bu n H 2-Br-4-S0 2 Me-Ph CH(Et)Bu n H 2-Br-4-N(Me) 2 -6-OMe-Ph CH(Et)Bu n H 2,4- [SMe] 2 -Ph CH(Et)Bu n H 2,4- [S0 2 Me] 2 -Ph CH(Et)Bu n H 2-Br-4,6-(OMe)2-Ph CH(Et)Pr n H 2-Cl-4,6- (0Me)2-Ph CH(Et)Pr n H 4-i-Pr-2-S e-Ph CH(Et)Pr n H 4-i-Pr-2-S0 2 Me-Ph CH(Et)Pr n H 4- (C0 e)-2-Br-Ph CH(Et)Pr n H 4-Br-2-CF3-Ph CH(Et)Pr n H 4-Br-2,6-(Me)2"Ph CH(Et)Pr n H 2,6-(Me)2-4-SMe-Ph CH(Et)Pr n H 101 2,6-(Me)2-4-S0 2 e-Ph CH(Et)Pr n H 102 2,6-(Me)2-4-CF 3 -Ph CH(Et)Pr n H 103 2-Br-4,6-(Me)2~Ph CH(Et)Pr n H 104 4-N(Et) 2 -2-Me-Ph CH(Et)Pr n H 105 2-I-4-i-Pr-Ph CH(Et)Pr n H 106 2-Br-4-SMe-Ph CH(Et)Pr n H 107 2-Br-4-S0 2 Me-Ph CH(Et)Pr n H 108 2-Br-4,6-(OMe)2-Ph CH(C2H5)2 H 108 ( . .163-165 °C) 109 2-Cl-4,6-(OMe)2-Ph CH(C2Hs)2 H 109 (m. .166-167 or) 110 4-i-Pr-2-SMe-Ph CH(C2H5>2 H 110 (m. .89-90 °C) 111 4-i-Pr-2-S0 2 e-Ph CH(C2H5>2 H 112 4-(COMe)-2-Br-Ph CH(C2Hs)2 H 113 2-Br-4-CF3-Ph CH(C2Hs)2 H 114 4-Br-2,6-(Me) 2 -Ph CH(C 2 H 5 ) 2 H Example 209 N- [2-bromo-4- ( 1-methylethyl ) phenyl] -2-methyl-9- ( 1-propylbutyl) - 9 H- pur in- 6 -amine Part A: The product of Part A (0.74 g) from Example 21 was treated with triethyl orthofor ate (7.68 g) and con. H2SO4 (3 drops) and heated to 100 °C for 4h. The excess triethyl orthoformate was removed in vacuum, and the residue was purified by flash column chromatography to yield 6-chloro-2 -methyl- 9- (1- propylbutyl) -9#-purine as a colorless liquid (0.32 g) . Part B: The product of Part A from above was combined with 2.-bromo-4-isopropylaniline in a manner similar to Part C of Example 21 to afford the title compound as a brown oil. Elemental analysis for C22H30Br 5: Theory C: 59.46, H: 6.80 N: 15.76. Found: C: 59.56, H: 6.83, N: 15.67. Example 210 (+/-)-»- [2-bromo-4- (1-methylethyl)phenyl] -9- (1- ethylpentyl)-2-methyl-9H-purin-6-amine Part A: The product of Part D from Example 1 was treated with 3-aminoheptane in a manner similar to Part A of Example 21, to yield 5-amino-4-chloro-6- (3-heptyl)amino-2-methylpyrimidine as a white crystalline solid (mp 116-117 °C) . Elemental analysis for C12H21CIN4: Theory C: 56.13, H: 8.24, N: 21.82. Found: C: 56.16, H: 8.26, N: 21.82 Part B: The product of Part A from above was treated with triethyl orthoformate in a manner similar to Part A of Example 209 to yield 6-chloro-9- (1- ethylpentyl)-2-methyl-9H-purιne as a pale yellow liquid. Part C: The product of Part B from above was combined with 2-bromo-4-isopropylaniline in a manner similar to Part C of Example 21 to afford the title compound as a colorless oil. Elemental analysis for C22H30BrN5: Theory C: 59.46, H: 6.80 N: 15.76. Found: C: 59.30, H: 6.82, N: 15.50. Example 211 (+/- ) -N- [2-bromo-4- (trif luromethyl ) phenyl] -9- [1- ( methoxymethyDpropyl] -2-methyl-9H-purin-6- amine Part A: The product of Part A from Example 27 was treated with triethyl orthoformate in a manner similar to Part A of Example 209 to yield 6-chloro-9- [1- (methoxymethyl) ropyl]-2-methyl-9H-purine as a white crystalline solid (mp 105-106 °C) . Elemental analysis for C11H15CIN4O: Theory C: 51.87, H: 5.95 N: 22.00. Found: C: 51.85, H: 5.81, N: 21.96. Part B: The product of Part A from above was combined with 2-bromo-4-trifluromethylaniline in a manner similar to Part C of Example 21 to afford the title compound as a off-white solid (mp 123-124 °C) . Elemental analysis for Ci8Hχ9BrF3N5θ: Theory C: 47.18, H: 4.19, N: 15.28. Found: C: 47.28, H: 3.97, N: 15.50. The compounds of Examples 212-217 can be made by methods exemplified in Examples 209-211. !9- Table 2 9H- imidazo [4 , 5-d] pyrimi ines : Example 218 N- [2-bromo-4- (1-methylethyl)phenyl] - N-ethyl-5- methyl- [1,2, 3]thiadiazolo [5,4-d]pyrimidin-7- amine Part A: The product of Part E (1.1 g) from Example 1 was dissolved in ethanol (15 mL) and added thiourea (0.27 g) . The reaction mixture was refluxed for lh, removed the solvent in vacuum, partitioned between CH2CI2 and water, washed with brine, dried and stripped down to a residue. The residue was purified by flash column chromatography (CH2CI2) to furnish the title compound as a white crystalline solid (1.01 g, mp 81-82 °C) . Elemental analysis for Ci4Hi4BrNsS: Theory C: 46.16, H: 3.87, N: 19.23, S: 8.80. Found: C: 46.15, H: 3.85, N: 19.09, S: 8.60. Part B: Using the procedure for Example 2, the product of Part A was alkylated to afford the title compound as a pale yellow oil. Elemental analysis for Cl6Hl8Br 5S: Theory C: 48.98, H: 4.62, N: 17.85. Found: C: 49.23, H: 4.71, N: 17.72. The compounds of Examples 219 and 220 can be made by the method of Example 218. Table 3 [1,2,3] -Thiadiazolo[5,4-d]pyrimidines: Ex. No. Ar Z R 219 2-Br-4-i-Pr-Ph S n-C3H7 220 2-Br-4-i-Pr-Ph S CH2~CH=CH2 Example 221 N- [2-bromo-4- ( 1-methylethyl ) phenyl] -1- ( 1- ethylpropyl ) - 6 -methyl- IH- l,2,3-triazolo[4,5-c] pyridin-4-amine Part A: 2,4-Dihydroxy-6-methyl-3-nitropyridine was added to phosphorous oxychloride in a manner similar to Part B of Example 1 to afford 2,4-dichloro- 3-nitro-6-methylpyridine as a pale yellow solid (mp 69-70 °C) . Part B: The product of Part A (10.35 g) from above was dissolved in ethanol .(100 mL) and then added triethylamine (5.05 g) followed by 3-aminopentane at room temperature under nitrogen atmosphere. The reaction mixture was stirred at room temperature for 4 days, ethanol was removed in vacuum, the residue was partitioned between ethyl acetate (150 mL) and water (150 mL) . The organic layer was washed with brine, dried, stripped down to a residue and purified by flash column chromatography to furnish 2-chloro-6- methyl-3-nitro-4-(3-pentyl)aminopyridine as a pale yellow solid (2.8 g; 84-85 °C) . Elemental analysis for CHHI6CI 3O2: Theory C: 51.27, H: 6.27, N: 16.30. Found: C: 51.28 , H: 6.09, N: 16.07. Part C: The product of Part B from above was reduced in a manner similar to Part C of Example 1 to afford 3-amino-2-chloro-6-methyl-4- (3- pentyl)aminopyridine as a cream colored solid (mp 165-166 °C) . Elemental analysis for C11H18CI 3: Theory C: 58.01, H: 7.98, N: 18.45. Found: C: 57.86, H: 7.83, N: 18.44. Part D: The product of Part C from above was cyclized in a manner similar to Part E of Example 1 to afford 4-chloro-l-(l-ethylpropyl)-6-methyl-lH-l,2,3- triazolo[4,5-c]pyridine as a light pink solid (mp 78- 79 °C) . Part E: The product of Part D from above was combined with 2-bromo-4-isopropylaniline in a manner similar to Part C in Example 21, to yield the title compound as a cream colored solid (mp 144-145 °C) . Elemental analysis for C2θH26 β rN5: Theory C: 57.69, H: 6.29, N: 16.82 Found: C: 57.82 , H: 6.29, N: 16.90. Example 222 N- (2-bromo-4, 6-dimethoxyphenyl) -1- ( 1- ethylpropyϊ) -6-methyl-lH-l, 2, 3-triazolo [4, 5-c] pyridin-4-amine The product of Part D from Example 221 was combined with 2-bromo-4, 6-dimethoxyaniline in a manner similar to Part C in Example 21, to yield the title compound as a off-white solid (mp 166-167 °C) . Elemental analysis for CιgH24BrN5θ2 : Theory C: 52.54, H: 5.58, N: 16.12 Found: C: 52.63, H: 5.53, N: 16.16. Example 223 N- (2-chloro-4, 6-dimethoxyphenyl ) -1- { 1- ethylpropyl) -6-methyl-1H-1, 2,3-triazolo[4,5-c] pyridin-4-ami e The product of Part D from Example 221 was combined with 2-chloro-4, 6-dimethoxyaniline in a manner similar to Part C in Example 21, to yield the title compound as an off-white solid (mp 168-169 °C) . Example 224 N- (2-bromo-4, 6-dimethoxyphenyl) -6-methyl-l- (1- propylbutyl)-1H-1, 2, 3-triazolo[4, 5-c]pyridin-4- a ine Part A: The product of Part A from Example 221, was treated with 4-aminoheptane in the same manner as outlined in Part B of Example 221 to furnish 2-chloro-4- (4-heptyl) amino-6-methyl-3-nitropyridine as an yellow oil. Elemental analysis for Ci3H20 c l N 3θ2 : Theory C: 54.64, H: 7.05, N: 14.70. Found: C: 54.93, H: 7.03, N: 14.62. Part B: The product of Part A from above was reduced in a manner similar to Part C of Example 1 to afford 3-amino-2-chloro-4- (4-heptyl)amino-6- methylpyridine as a cream colored solid (mp 139-140 °C) . Part C: The product of Part B from above was cyclized in a manner similar to Part E of Example 1 to afford 4-chloro-6-methyl-l- (1-propylbutyl)-ltf-1,2,3- triazolo[4, 5-c]pyridine as an orange yellow solid (mp 90-91 °C) . Part D: The product of Part C from above was combined with 2-bromo-4,6-dimethoxyaniline in a manner similar to Part C in Example 21, to yield the title compound as a brick red colored solid (mp 140-141 °C) . Elemental analysis for C2lH28BrN5θ2: Theory C: 54.55, H: 6.10, N: 15.15 Found: C: 54.83, H: 5.95, N: 15.11. Example 225 N- (2 -chloro- 4, 6 -dimethoxyphenyl) -6-methyl-l- (1- propylbutyl) -1H-1, 2, 3 -triazolo [4, 5-c]pyridin-4- amine The product of Part C from Example 224 was combined with 2-chloro-4, 6-dimethoxyaniline in a manner similar to Part C in Example 21, to yield the title compound as a brick red colored solid (mp 157- 158 °C) . Elemental analysis for C21H28CIN5O2 : Theory C: 60.35, H: 6.75, N: 16.76 Found: C: 60.43, H: 6.74, N: 16.99. Example 226 (+/- ) - N- [2-bromo-4- (1-methylethyl)phenyl]-1- (1- ethylpentyl)-6-methyl-1H-1,2,3-triazolo[4,5- c]pyridin-4-ami e Part A: The product of Part A from Example 221, was treated with 3-aminoheptane in the same manner as outlined in Part B of Example 221 to furnish 2-chloro-4- (3-heptyl)amino-6-methyl-3-nitropyridine as an yellow solid (mp 48-49 °C) . Elemental analysis for C13H20CIN3O2: Theory C: 54.64, H: 7.05, N: 14.70. Found: C: 54.79, H: 6.95, N: 14.67. Part B: The product of Part A from above was reduced in a manner similar to Part C of Example 1 to afford 3-amino-2-chloro-4- (3-heptyl)amino-6- methylpyridine as a cream colored solid (mp 139-140 °C) . Part C: The product of Part B from above was cyclized in a manner similar to Part E of Example 1 to afford 4-chloro-1- (1-ethylpropyl) -6-methyl-IH-1,2, 3- triazolo[4, 5-c]pyridine as a colored liquid. Elemental analysis for C13H19CIN4: Theory C: 58.53, H: 7.19, N: 21.00. Found: C: 58.69, H: 7.06, N: 20.76. Part D: The product of Part C from above was combined with 2-bromo-4-isopropylaniline in a manner similar to Part C in Example 21, to yield the title compound as a light pink colored solid (mp 73-74 °C) . Elemental analysis for C22H3θBr 5: Theory C: 59.46, H: 6.80, N: 15.76, Found: C: 59.56, H: 6.70, N: 15.70. Example 227 (+/- ) -_y- (2-bromo-4, 6 - dimethoxyphenyl ) -1- ( 1- ethylpentyl) - 6 -methyl -1H-1, 2, 3 -triazolo [4, 5- c] pyr i din- 4 -amine The product of Part C from Example 226 was combined with 2-bromo-4, 6-dimethoxyaniline in a manner similar to Part C in Example 21, to yield the title compound as a brick red colored solid (mp 127-128 °C) . Elemental analysis for C2lH28BrN5θ2 : Theory C: 54.55, H: 6.10, N: 15.15. Found: C: 54.78, H: 5.84, N: 14.92. Example 228 (+/- ) -N- (2-chloro-4, 6 - dimethoxyphenyl ) -1- ( 1- ethylpentyl)-6-methyl-lff- 1,2, 3 -triazolo [4,5- c] pyr i din- 4 -amine The product of Part C from Example 226 was combined with 2-chloro-4, 6-dimethoxyaniline in a manner similar to Part C in Example 21, to yield the title compound as a brick red colored solid (mp 155- 156 °C) . Elemental analysis for C21H28CI 5O2 : Theory C: 60.35, H: 6.75, N: 16.76. Found: C: 60.36, H: 6.65, N: 16.84. Example 229 N- [2-bromo-4- ( 1-methylethyl ) phenyl] -6-methyl-l- (1-propylbutyD-lH- 1,2, 3 -triazolo [4, 5- c ] pyr i din- 4 - amine Part A: 4-Chloro-6-methyl-3- nitropyridone: 4-Hydroxy-6-methy1-3-nitropyridone (4.0 g, 23,52 mmol) was treated with cyclohexylamine (2.8 mL, 24.46 mmol) in MeOH (50 mL) until all dissolved. The MeOH was stripped in vacuo and the resulting salt was dried and treated with POCI3 (30 mL) at 25 °C for 30 h. The reaction was then poured into ice/water (400 mL) and extracted with EtOAc (2x200 mL) . The combined EtOAc extracts were washed with water (100 -mL), 1 N NaOH (20 mL) , water (100 mL) and brine, dried (MgSθ4) and stripped in vacuo. The residue was washed with 20% EtOAc/hexanes (2x30 mL) to give the product (2.9 g) . Part B: 6-Methyl-3-nitro-4- (1- propylbutylamino) pyridone: 4-Chloro-6-methyl-3- nitropyridone (2.9 g, 15.40 mmol) was treated with 1- propylbutylamine (4 mL, 26.8 mmol) in CH3CN (30 mL) at 25 °C for 64 h and at reflux for 2 h. The reaction mixture was partitioned between EtOAc (200 mL) and water (50 mL) . The EtOAc was washed with water (2x50 mL) , brine, dried (MgSθ4) and stripped in vacuo. The residue was washed with 20% EtOAc/hexanes (2x20 mL) to give the product (3.7 g) . Part C: 2-Chloro-6-methyl-3-nitro-iV- (1-propyl-butyl)pyridin-4-amine: 6-Methyl-3- nitro-4- (1-propylbutylamino) pyridone (3.7 g, 13.84 mmol), was treated with POCI3 (14 mL) at 25 °C for 20 h. Then it was poured into ice/water (200 mL) and extracted with EtOAc (300 mL) . The EtOAc was washed with water, brine, dried (MgSθ4) and stripped in vacuo. The residue was chromatographed on silica gel (20% EtOAc/hexanes eluting solvent) to give the product (3.3 g) . Part D: N- [2-Bromo-4- (1- methylethyl)phenyl] -6-methyl-3-nitro-Λ r - (1- propylbutyl)pyridin-2,4-diamine: 2-Chloro-6- methyl-3-nitro-N- (l-propylbuty)pyridin-4-amine (0.5 g, 1.75 mmol) and 2-bromo-4-isopropylaniline (0.74 g, 3.5 mmol) were heated at 140 °C for 4.5 h. After cooling it was dissolved in CH2CI2 and filtered through a short column of silica gel. The filtrate was concentrated and chromatographed on silica gel (5% EtOAc/hexanes eluting solvent) to give the product (0.7 g) . Part E: N- [2-Bromo-4- ( 1- methylethyl)phenyl] -6-methyl -N- (1-propylbuty) pyridine-2,3,4-triamine: N- [2-Bromo-4- (1- methylethyl)phenyl] -6-methyl-3-nitro-N- (1-propyl- butyl) yridin-2,4-diamine (0.7 g, 1.51 mmol), was suspended between dioxane (30 mL) and water (30 mL) containing conc.ΝH40H (1.2 mL) . To that a2S2θ4 was added (2.1 g, 12.06 mmol) and the mixture was stirred at 25 °C for 2h. Then an additional Ig Na2S2θ4 was added followd by 10 mL dioxane and 10 mL water. After stirring for 1 h at 25 °C the mixture was patritioned between EtOAc (120 mL) and water (20 mL) . The EtOAc was washed with water (100 mL) , brine, dried (MgSθ4) and stripped in vacuo. The residue was chromatographed on silica gel (20% EtOAc/hexanes eluting solvent) to give the product (0.5 g) . Part P: N- [2-bromo-4- ( 1- methylethyl ) henyl] -6-methyl-l- ( 1-propylbutyl ) - 1H-1,2, 3-triazolo [4, 5-c]pyridin-4-amine: N- [ 2 - Bromo-4- (1-methylethyl) henyl] -6-methyl-N- (1- propylbutyl) pyridine-2, 3, 4-triamine (0.5 g, 1.15 mmol), dissolved in CH2CI2 (6 mL) and 50% AcOH (4 mL) was treated with NaN02 (0.0846 g, 1.22 mmol) at 25 °C for 16 h. The mixture was patritioned between EtOAc (100 mL) and water (20 mL) The EtOAc was washed with water (20 mL) , brine, dried and stripped in vacuo. The residue was chromatographed on silica gel (20% EtOAc/hexanes eluting solvent) to give the product (0.2 g) . Anal. Calcd. for C22H3θBr 5: C, 59.46; H, 6.80; N, 15.76; Br, 17.98. Found: C, 59.76; H, 6.83; N, 15.67; Br, 18.17. Example 231 N- [4- (1-methylethyl) -2-sulfonylmethylphenyl] -6- methyl-l-(l-proρylbutyl)-lH-1,2,3-triazolo[4, 5- c] pyridin-4-amine N- [4- (1-methylethyl)-2-thiomethylphenyl]-6- methyl-1- (1-propylbutyl) -1H-1,2,3-triazolo[4,5- c]pyridin-4-amine (0.15 g, 1 equiv.) (Example 231), synthesized under the same general conditions of Example 229, was dissolved in methanol (3 mL) and water (2 mL) was added, followed by Νalθ4 (0.114 g, 1.5 equiv.). The mixture was stirred at 25 °C for 20 h and then was extracted with EtOAc (80 mL) . The EtOAc was washed with water, brine, dried and stripped in vacuo. The residue was dissolved in CH2CI2 and a solution of KMnθ4 (0.15 g, 2.5 equiv.) in water (2 mL) was added, followed by benzyltriethylammonium chloride (0.15 g, 1.5 equiv.). The mixture was stirred at 25 °C for 20 h and then extracted with EtOAc (80 mL) and the EtOAc was washed with water, brine, dried and stripped in vecuo. The residue was chromatographed on silica gel (10% EtOAc/hexanes eluting solvent) to give the product (0.2 g) . Anal. Calcd. for C23H33BrNsθ2S: C, 62.27; H, 7.51; N, 15.79; S, 7.24. Found: C, 62.62; H, 7.38; N, 15.58 S, 7.44. Example 232 N- [4- (4-acetyl-2-bromophenyl] -6-methyl-l- (1- propyl- butyl) -1H-1, 2, 3-triazolo [4, 5-c]pyridin- 4 -amine PART A: Used the standard procedure for the coupling of the nitropyridine (0.8 g, 2.9 mmoles) and 2-Bromo-4-iodoaniline (1.7 g, 5.7 mmoles) . Preabsorbed the crude material on 12 g. of silica gel before chromatographing on silica gel (5% EtOAc/hexane eluen) to give an orange solid, 1.47 g. of the desired product . PART B: o the coupled 2-Bromo-4- iodoanilinonitropyridine (0.60.g, 1.1 mmoles) in a dried flask, under nitrogen, was added Bis (triphenylphosphine)palladium(II)chloride (18 mg, 0.026 mmoles) and anhydrous toluene (5 mL) . Added 1- Ethoxyvinyltributyltin (0.46 ml, 1.36 mmoles) and stirred at reflux temperature for 1 1/2 hours. Dissolved into ethyl acetate then filtered off the insolubles through celite. Washed the solids 2 x with ethyl acetate. Concentrated in-vacuo the filtrates to near dryness. Stirred the residue with 70 ml 1M hydrochloric acid for 1/2 hour. Added some ethyl acetate and separated the layers., extracted the water layer with 2 x 20 ml ethyl acetate. Concentrated the combined organics to near dryness. Stirred the residue in a saturated potassium fluoride (20 ml) for 1/2 hour. Separated the layers. Extracted the water layer with 2 x 20 ml ethyl acetate. Washed the combined extracts with 10 ml water and 20 ml brine. Chromatographed the crude material on silica gel to give a solid, 0.37 g (73 %) of the desired product. PART C: Using the product obtained from Part B (0.70 g, 1.5 mmoles), 10 ml tetrahydrofuran, 10 ml water, 0.70 ml ammonium hydroxide solution (38-40%) and sodium dithionite (2.1 g, 12 mmoles) followed the standard procedure to reduce the nitroanilinopyridine. Obtained the crude solid, 0.65 g, which was of sufficient purity for further reaction. PART D: Followed the standard procedure to cyclize the product obtained in Part C (0.63 g, 1.45 mmoles) , using 10 ml methylene chloride, 10 ml acetic acid/water (50%) , and sodium nitrite (0.18 g, 2.59 mmoles) in 1 ml water. Chromatographed on silica gel (10% ethyl acetate / hexane) to give a white solid, 0.31 g, (48%) of desired product, mp 165-166 °C. Anal. Calcd. " for C2lH26BrNsO: .C, 56.76; H, 5.91; N, 15.76; Br, 17.98. Found: C, 56.75; H, 5.76; N, 15.71; Br, 17.72. Obtained the isomer of the desired product, a white solid, 90 mg, mp 133-136 °C. Anal. Calcd: Found: C, 57.11; H, 5.82; N, 15.69; Br, 18.23. The rest of the examples shown in Table 4 were prepared by following the general procedure outlined in Example 229. Table 4 lH-l,2,3-triazolo[4,5-c] pyr i dines : Example 259 N- (2-chloro-4, 6-dimethylphenyl) -1- [1- methoxymethyl- (2-methoxyethyl] -6-methyl-1H- 1,2, 3-triazolo[4, 5-c]pyridin-4-amine: Part A: Serinol (24 g) was added to a solution of trityl chloride (65 g) and triethylamine (51.0 g) in 600 mL of dry DMF. After stirring at room temperature for 48 h, the reaction was poured into water and extracted several times with diethyl ether. The combined organic layers were dried over anhydrous magnesium sulfate and concentrated to dryness to afford N-triphenylmethylserinol (71.0 g) . Part B: Methyl iodide (90 mL) was added to a suspension of N-triphenylmethylserinol (37.0 g) and powdered sodium hydroxide (45.0 g) in 400 mL of dry DMSO. After stirring at room temperature for 24-36 h, the reaction was added to water (800 mL) and extracted with diethyl ether (3 X 500 mL) . The combined organic layers was washed with water (4 X 250 mL) , dried over anhydrous magnesium sulfate and concentrated to.afford 1, 3-dimethoxy-2- triphenylmethylaminopropane (36.0 g) as a thick viscous oil. Part C: To a solution of the product of Part B (36.0 g) in methanol (400 mL) was added 1 M HCl in ether (350 mL) . After stirring overnight, the reaction was poured over water (800 mL) extracted with hexane (3 X 250 mL) . The methanol/water layer was concentrated to dryness to afford 1, 3-dimethoxy-2- aminopropane hydrochloride (14.0 g) as a waxy solid. Part D: 4-Chloro-6-methyl-3-nitro-2- pyridone: 4-Hydroxy-6-methyl-3-nitro-2-pyridone (50.0 g) was treated with cyclohexylamine (40 g) in MeOH (300 mL) and heated until all dissolved. The MeOH was stripped in vacuum and the resulting salt was dried and treated with POCI3 (360 mL) at 25 °C for 48 h. The excess P0C1 3 was removed under vacuum and the residue was poured into ice/water (1000 mL) and extracted with EtOAc (4x250 mL) . The combined EtOAc extracts were washed with aq. NaHC0 , brine (3 *100 mL) , dried (MgSθ4) and stripped in vacuum. The residue was washed with 20% EtOAc/hexanes (2x100 mL) to afford the product as a yellow solid(41.3 g; mp 225 °C) . Part E: 4- [1-methoxymethyl-(2- methoxyethyl]amino-6-methyl-3-nitro-2-pyridone: 4-Chloro-6-methyl-3-nitro-2-pyridone (12.12 g; from part D) was treated with 1, 3-dimethoxy-2-aminopropane hydrochloride (10.0 g; from part C) in CH3CN (200 mL) and diisopropylethylamine (20.0 g) at 25 °C for 24 h and at reflux for 3 h. The reaction mixture was partitioned between EtOAc (200 mL) and water (50 mL) . The EtOAc was washed with water (2x50 mL) , brine, dried (MgS04) and stripped in vacuum to give the product as a yellow solid(9.4 g; m.p.172-173 °C) . Part. P: 2-Chloro-N- [1-methoxymethyl- (2-methoxyethyl] -6-methyl-3-nitro-pyridin-4- amine: 4- [1-methoxymethyl- (2-methoxyethyl]amino-6- methyl-3-nitro-2-pyridone (9.4 g from part E) , was treated with POCI3 (55 mL) at 25 °C for 24 h. The excess POCI3 was removed under vacuum, and the residue was poured into ice/water (200 mL) and extracted with CH 2 C1 2 (3 X 150 mL) . The combined CH C1 extract was washed with water, dried (MgSθ4) and stripped in vacuum to give the product as a yellow solid (9.0 g; m.p. 85-87 °C) . Part G: 2-Chloro-4- [1-methoxymethyl- (2-methoxyethyl]amino-6-methylpyridin-3-amine: The product of Part F (9.0 g) was added to acetic acid (80 mL) and methanol (400 mL) . To this mixture was added iron powder (9.0 g) in portions, stirred for 5 h at 60-65 °C, cooled to room temperature, and filtered through celite. The filtrate was stripped to a brown solid, which was extracted with ethyl acetate ( 2 x 150 mL) , washed with NaHC0 (100 mL) , and brine (100 mL) . The organic layer was dried over anhydrous magnesium sulfate, filtered and stripped down to yield the product as a pale yellow solid (5.6 g; m.p. 100 °C) . Part H: 4-Chloro-l- [1-methoxymethyl- (2- ethoxyethyl] -6-methyl-lH-l,2, 3-triazolo[4, 5- clpyridine: The product of Part G (5.4 g) was dissolved in dichloromethane (100 mL) and 50 % aqueous acetic acid (100 mL) . To this stirred mixture was added sodium nitrite (1.7 g) in water (10 mL) dropwise at room temperature. After completion of addition, the reaction was stirred for an additional 15 mins. The organic layer was separated, washed with water, dried with anhydrous magnesium sulfate, and stripped down to a residue. The residue was purified by flash column chromatography (CH2CI2) to afford the product as a pale yellow solid (5.4 g>- m.p. 49-50 °C) . Part I: N- (2-chloro-4, 6-dimethylphenyl) -1- [1-methoxymethyl- (2-methoxyethyl] -6-methyl-lH- 1,2,3-triazolo[4,5-c]pyridin-4-amine: The product of Part H (2.0 g) from above was combined with 2-chloro-4, 6-dimethylaniline (1.4 g) in the presence of p-toluenesulfonic acid (1.7 g) in toluene (25.0 mL) at 110 °C for 4h. The reaction mixture was partitioned between EtOAC (50 L) and aq. NaHC0 3 (50 mL) , washed the organic layer with brine, dried and stripped in vacuum to a residue. The residue was purified by flash column chromatography (1:100: :MeOH: CH2CI2) to afford the title compound as white solid (1.7 g; mp 83-84 °C) after crystallization from ether/pentane. Elemental analysis for C19H24CIN 5 O2: Theory C: 58.53, H: 6.20, N: 17.96, Cl: 9.09. Found: C: 58.69, H: 6.32, N: 17.97, Cl.-9.18. Part J: Mesylate salt of N- (2-chloro-4 , 6- dimethylphenyl) -1- [1-methoxymethyl- (2- methoxyethyl] -6-methyl-lH-l, 2,3-triazolo[4,5- c]pyridin-4-amine: The product of Part I (850 mg) was dissolved in dichloromethane (5.0 mL) and then added methanesulfonic acid (250 mg) . The solvent was removed and the residue was crystallized from 2- propanol (2.5 mL) to afford the mesylate salt (920 mg; m.p. 179-180 °C) as a white crystalline solid. Elemental analysis for C20H28CIN5O5S: Theory C: 49.43, H: 5.82, N: 14.41. Found: C: 49.42, H: 5.79, N: 14.37. The compounds listed in Tables 5 and 6 were prepared by the methods exemplified in Examples 1-53 and 526. Table 5 3H-l,2,3-triazolo[4, 5-d] pyr imi dines 322 2,4-(SMe) 2 -Ph 323 2-Br-.4-N(Me) 2 -Ph 324 2-Cl-4-CN-6-Me-Ph 325 2-Cl-4-CN-Ph 326 2,4,5- (Me) 3 -Ph 327 2,4-(Me) 2 -Ph 328 4-Br-2,6-(Et) 2 -Ph 329 4-Br-2,6-(Cl) 2 -Ph 330 2-Br-4,6-(Cl) 2 -Ph 331 2,6-(Br) 2 -4-Cl-Ph 332 4-Br-2-Me-6-N0 2 -Ph 333 4-OMe-2-Me-Ph 334 2,5-Cl 2 -4-NMe2-Ph 335 2,4-Cl2-Ph 336 2-Br-4-Cl-Ph 337 4-Cl-2-Me-Ph 338 4-1-2, 6-Me 2 -Ph 339 4-NMθ2-2,6- (Me)2"Ph 340 2-Cl-4-Me-Ph 341 2-Br-4-OMe-Ph 342 2-Me-4-CH 2 OMe-Ph 343 2,4,6-Me 3 -Ph 344 2-Cl-4,6-Me 2 -Ph 345 4-Br-2,6-Me 2 -Ph 346 2,4-Me 2 -Ph 347 2-Br-4-Me-Ph 348 2,4,6-Me -Ph 349 2,4,6-Me3-Ph 350 2-Cl-4,6-Me 2 -Ph 351 4-Br-2,6-Me 2 -Ph 352 2,4-Me 2 -Ph 353 2-Br-4-Me-Ph 354 2,4,5-Me 3 -Ph 355 2,4,6-Me 3 -Ph 356 2-Cl-4,6-Me2-Ph 357 4-Br-2,6-Me 2 -Ph 358 2,4-Me 2 -Ph Note: (+) , (-), (R) or (S) denotes respective isomers Table 6 3H-l,2,3-triazolo[4, 5-d] pyr imi dines Ex. No. Ar Rl m.p. (°C! 401 2,4,6-Me 3 -Ph H 146-147 402 4-Br-2,6-Me 2 -Ph H 139-140 403 2,4,6-Me 3 -Ph CF 3 176-177 404 4-Br-2,6-Me 2 -Ph CF 3 183-184 405 2-Cl-4,6-Me 2 -Ph CF 3 174-175 406 2,4-Cl 2 -6-Me-Ph CF 3 160-161 407 2-Cl-4,6-Me 2 -Ph C 2 H 5 111-112 408 2-Cl-4,6-Me 2 -Ph MeOCH 2 87-88 Example 409 6- [N- (2-chloro-4, 6-dimethylphenyl ) ] -9- [ (1- methoxymethyl ) propyl] -2-methyl-9H-purin- 6, 8 -di amine Part A: 2-methyl-4-chloro-6- (1-methoxymethyl ) propylamino-5-aminopyridine (450 mg, 1.84 mmol) was reacted with cyanogen bromide (234 mg, 2.2 mmol) in refluxing methanol for 24 h. The solvent was removed in vacuo and the resulting crude oil was taken up in ethyl acetate and washed 3 times with saturated aqueous NaHCθ3. The organic layer was dried then stripped in vacuo and the crude product was chromatographed on silica gel (20 g, ethyl acetate neat) providing 240 mg (48%) of 8-amino-6-chloro-9-[ (1-methoxymethyDpropyl-2- methyl-9H-purine. Part B: The product from part B (50 mg, 0.20 mmol) was treated with 2-chloro-4,6-dimethylaniline (30 mg, 0.20 mmol) in refluxing 1.0 N HCl for 24 h. The reaction was cooled then poured into saturated aqueous NaHC03 and extracted (3 times 50 ml) with ethyl acetate. The organic fractions were combine, dried and stripped in vacuo. The resulting crude product was chromatographed on silica gel (20 g, ethyl acetate neat) providing 55 mg (71%) of the title compound. Anal. Calcd. for C19H25N6OCI: C, 58.76; H, 6.44; N, 21.65. Found: C, 58.50; H, 6.32; N, 21.72. The compounds of Table 7 can be made by the methods exemplified in Examples 209-211 and 409. -Ill- Table 7 9H-imidazo [4 , 5-d] pyrimidine s ; Ar Ex. No. Ar R 2 R3 m.p. (°C: 410 2,4,6-(Me)3-Ph H CH(Et )CH2θCH3 212-213 411 2,4,6-(Me)3-Ph NH 2 CH (Et ) CH2OCH3 oil 412 2-Cl-4,6-(Me)2-Ph NH 2 CH(CH2θCH3)2 oil 413 2,4,6-(Me)3-Ph NH 2 CH(CH2θCH3)2 oil Example414 (S) - (- ) -N- (2-chloro-4, 6-dimethylphenyl] -6- methyl- 1- ( 1-methoxymethyl- 3 -methoxypropyl ) -1H- 1, 2, 3 -triazolo [4, 5-c] pyridin-4-amine Part A: L-Dimethyl aspartate hydrochloride (5 g, 25.3 mmol) and triphenylmethyl chloride (7.65 g, 27.5 mmol) were suspended in dry CH 3 CN (50 mL) at 0 °C. To that Et 3 N (4.5 mL, 32.3 mmol) was added dropwise, followed by N-methylmorpholine (2.5 mL, 27.5 mmol). The mixture was stirred at 0 °C for 1 h and at 25 °C for 30 min. Then it was partitioned between EtOAc (200 mL) and water (50 mL) and the organic extract was washed with water (50 mL) , brine (50 mL) , dried (MgSθ 4 ) and stripped in vacuo. The product, diethyl N- triphenylmethyl aspartate, was >90% clean by NMR analysis. NMR (CDCl 3 )δ 7.16-7.51 ( , 15 H) , 3.68 (s, 3H) , 3.66-3.74 (m, IH) , 3.26 fs, 3H) , 2.93 (d, IH, J=9.9Hz), 2.63-2.69 (dd, IH, Jι=14.6, J 2 =5.1 Hz), 2.48-2.55 (dd, IH, Jι=14.6 Hz, J 2 =7 Hz) . Part B: (S)-Diethyl N-triphenylmethyl aspartate (-25 mmol) was dissolved in dry THF (150 mL) and cooled to 0 °c To that a 1 M solution of of LiAlH 4 in THF (50 mL, 50 mmol) was added dropwise and the reaction was stirred for 2 h and allowed to warm to 25 °C. Then it was cooled and quenched with water (5 mL) and 1 N NaOH (4 mL) , diluted with ether (200 mL) and the precipitated solids were filtered off. The filtrate was concentrated in vacuo to give the product, 2-N-triphenylamino-l,4- butane diol (>90% clean by NMR analysis) . NMR(CDC1 3 )57.17-7.57 ( , 15H) , 3.68-3.77 (m, IH) , 3.56- 3.63 (m, IH), 3.19 (d, IH, J=8.8 Hz), 2.76-2.86 (m, 2H) , 2.2-2.7 (br, 3H), 1.54-1.63 (m, IH) , 1.36-1.54 (m, IH) . Part C: (S) -2-N-triphenylamino-l,4-butane diol (-25 mmol) dissolved in dry THF (50 mL) was added into a suspension of NaH 60% in oil (2.34 g, 58.5 mmol) in dry THF (50 mL) at 0 °C, and the mixture was stirred at 9 °C for 30 min and at 25 °C for 1 h. Then it was cooled in an ice bath and CH 3 I (3.6 mL, 58.5 mmol) was added dropwise. The reaction was stirred at 0 °C for 30 min and at 25 °C for 2 h, the excess NaH was quenched with water and the THF was stripped off. The residue was partitioned between EtOAc (200 mL) and water (50 mL) and the organic extract was washed with water (50 mL) , brine (50 mL) , dried (MgS0 4 ) and stripped in vacuo. The product, 2-N-triphenylamino-l,4-dimethoxy butane was >90% clean by NMR analysis. NMR(CDCl 3 )δ 7.15-7.59 (m, 15 H) , 3.34-3.41 (m, IH) , 3.22 -3.30 (m, IH) , 3.24 (s, 3H) , 3.03 (s, 3H) , 2.86 (dd, IH, J l =9.5 Hz, J 2 =3.3 Hz), 2.65-2.75 (m, IH) , 2.4-2.46 (br, IH) , 2.30-2.35 ( , IH) , 2.57-2.8 (m, 2H) . Part D: (S) -2-N-Triphenylamino-l,4-dimethoxy butane (-25 mmol) was dissolved in a mixture of CH 2 C1 2 (100 mL) and methanol (50 mL) and 1 M HCl in ether was added (50 mL) . The reaction was stirred at 25 °C for 16 h, the solvent was stripped off and the residue was washed with 1:1 ether/hexane (3x50 mL) . The remaining oil, 2-amino-l,4-dimethoxybutane hydrochloride, was dried under vacuum (3.87 g, 88%). NMR(CDCl 3 )δ 8.2-8.5 (br, 3H) , 3.5-3.7 (m, 5H) , 3.41 (s, 3H), 3.36 (s, 3H), 2.05-2.2 (m, IH) , 1.90-2.01 (m, IH) . Part E: (S)-6-Methyl-3-nitro-4-(l- methoxymethyl-3-methoxypropylamino) pyridone: 1- methoxymethyl-3-methoxypropylamine (4.19 g, 22.3 mmol), and 4-chloro-6-methyl-3-nitropyridone (3.87 g, 22.3 mmol) were mixed in CH 3 CN (70 mL) and diisopropyl- ethylamine (9.4 mL, 53.6 mmol) was added. The reaction was stirred at 25 °C for 16 h and at reflux for 2.5 h. The solvent was stripped off and the residue was dissolved in CH 2 C1 2 (150 mL) and the CH 2 C1 2 was washed with water (80 mL) . The water was extracted with CH 2 C1 2 (50 mL) and the combined organic extracts were dried (MgS0 4 ) and stripped in vacuo. The residue was crystallized from EtOAc and washed with 40% EtOAc/hexanes to give the product, (4.8 g, 75%) . NMR(DMSO)δ 9.13 (d, IH, J=8.8 Hz), 5.9 (s, IH) , 3.92- 4.02 (m, IH) , 3.20-3.25 (m, 2H) , 3.28-3.4 (m, 2H) , 3.25 (s, 3H) , 3.18 (S, 3H), 2.09 (s, 3H) , 1.65-1.90 (m, 2H) . Part P: ( S ) -2 - Chloro- 6 -methyl - 3 -nitro- W r - ( 1- methoxymethyl- 3 -methoxypropyl ) pyr idin- 4 - amine : 4 - [ 3 - ( 1 , 4-dimethoxybutyl ) amino] -6-methyl- 3-nitropyridone ( 4 . 8 g , 16 . 82 mmol ) was dissolved in POCl 3 ( 50 mL) and stirred at 25 °C for 40 h . Then the reaction was poured into ice/water ( 500 mL) , allowed to react , neutralized with solid NaHC0 3 after EtOAc was added ( 150 mL ) and extracted with EtOAc (2x300 mL) . The EtOAc was dried (MgS0 4 ) and stripped in vacuo to give the product. NMR (CDC1 3 )57.08 (d, IH, J=7.7 Hz), 6.65 (s, IH) , 3.85- 3.95 (m, IH) , 3.30-3.50 (m, 4H) , 3.38 (s, 3H) , 3.33 (s, 3H), 2.43 (S, 3H) , 1,80-2.02 (m, 2H) . Part G: (S)-3-amino-2-chloro-4-lV- (1- methoxymethyl-3-methoxypropyl) -6-methyl-pyridin- 4-amine: 2-Chloro-6-methyl-3-nιtro-N- (1-methoxymethyl- 3-methoxypropyl)pyridin-4-amine (-16.82 mmol) was heated at reflux with Fe powder (10 g) in methanol (120 mL) in the presence of glacial acetic acid (10 mL) for 2 h. Then the iron was filtered through celite, the celite was washed with methanol(80 mL) and the filtrate was stripped in vacuo. The residue was dissolved in 10% HCl (120 mL) and EtOAc was added (160 mL) . The mixture was neutralized with solid ΝaHC0 3 and the aqueous layer was extracted with EtOAc (2x100 mL) . The combined organic extracts were washed with brine (50 mL) , dried (MgS0 4 ) and stripped in vacuo (4.1 g) . NMR(CDCl 3 )d 6.4 (s, IH) , 5.2-5.35 (br s, IH) , 3.70-3.80 (m, IH) , 3.2-3.8 ( , 6H) , 3.38 (s, 3H) , 3.33 (s, 3H) , 2.42 (s, 3H), 1.8-2.0 (m, 2H) . Part H: <S) -4-chloro-l- ( l-methoxymethyl-3- methoxypropyl ) - 6 -methyl -IH- l,2,3-triazolo[4,5- c]pyridine: 3-amino-2-chloro-6-methyl-4-N- (1- methoxymethyl-3-methoxypropyl)pyridin-4-amine (4.1 g, 14.98 mmol) was dissolved in a mixture of CH 2 C1 2 (40 mL) and 50% acetic acid (40 mL) and cooled to 0 °C in an ice bath. To that a solution of ΝaΝ0 (1.84 g, 26.86 mmol) in water (10 mL) was added dropwise and the reaction was stirred at 0 °C for 30 min and at 25 °C for 1.5 h. Then the acetic acid was neutralized with solid NaHC0 3 and water (80 mL) was added. The mixture was extracted with EtOAc (2x100 mL) and the combined organic extracts were combined and washed with brine (50 mL) , dried and stripped in vacuo. The residue was chromatographed on silica gel (40%- EtOAc/hexanes eluent) to give the product (4.05 g, 56% overall for the eight steps). NMR(CDCl 3 )δ 7.25 (s, IH) , 5.04-5.13 (m, IH) , 3.98 (dd, IH, Jι=9.9 Hz, J 2 =8.4 Hz), 3.84 (dd, IH, Jι=10.2 Hz, J 2 =4.4 Hz), 3.39 (dt, IH, Jχ=9.9 Hz, J 2 =4.8 Hz), 3.25 (s, 3H) , 3.17 (s, 3H) , 2.91 (dt, IH, J 1= 9.5 Hz, J 2 =4.0 Hz), 2.68 (s, 3H) , 2.22-2.6 (m, 2H) . Part I: (S) -4-chloro-l- (l-methoxymethyl-3- methoxypropyl)-6-methyl-1H-1,2,3-triazolo[4, 5-c]pyridine (2.0 g, 7 mmol) and 2-chloro-4,6-dimethylaniline (1.094 g, 7 mmol) were dissolved in dry THF and cooled to 0 °C in an ice bath. To that a 1 M solution sodium hexamethyldisilazide (16 mL, 16 mmol) was added dropwise and the solution was stirred at 0 °C for 45 min. Then it was quenched with water (30 mL) and partitioned between EtOAc and water (20 mL) . The organic extract was washed with brine (50 mL) , dried (MgS0 4 ) and stripped in vacuo. The residue was purified by silica gel chromatography (40% EtOAc/hexanes eluent) and crystallized from hexanes to give the product (2.42 g, 85%), mp 108-109 °C, [α]D25 -32.38 (c=0.200 g/dL, CHC1 3 ) 99.6% ee by chiral HPLC. This was converted to the methylsulfonate salt, mp 98- 100 °C, after crystallization from ether/hexanes, [α]D25 -29.00 (c=0.200 g/dL, CHC1 3 ). Example 414A (R,S)-N- (2-chloro-4,6-dimethylphenyl]-6-methyl- 1- (1-methoxymethyl-3-methoxypropyl)-lJϊ-1,2,3- triazolo[4, 5-c] pyridin-4-amine Part A: (R,S) -2-Aminobutyrolactone hydrobromide (8.0 g, 44 mmol) and triphenylmethyl chloride (12.8 g, 46 mmol) were suspended in dry CH 3 CN (80 mL) at 25 °C. To that Et 3 N (13.6 mL, 100 mmol) was added dropwise, the reaction mixture was stirred at 25 °C for 4 h and partitioned bet-ween EtOAc (120 mL) and water (50 mL) . The organic layer was washed with water (50 mL) , brine (50 mL) , dried ( gSθ 4 ) and stripped in vacuo. The residue was recrystallized from EtOAc/hexanes to give 2- triphenylmethylamino-butyrolactone (10.5 g) . Part B: Lithium aluminum hydride (1.4 g, 36 mmol) was suspended in dry THF (50 mL) and cooled to 0 °C in an ice bath. To that a solution of 2- triphenyl ethylamino-butyrolactone (11 g, 31.9 mmol) in dry THF (70 mL) was added dropwise over a period of 20 min. After the addition was over the reaction mixture was stirred at 0 °C for 1 h, at 25 °C for 3h and quenched by the sequential addition of water (2 mL) I N NaOH (2 mL) and water (3 mL) , and diluted with ether (150 mL) . The precipitated solids were filtered off and the filtrate was concentrated in vacuo to give (R,S)-2- N-triphenylamino-l,4-butanediol. This was used in the same synthetic scheme as previously described for the chiral material (Example 414, Parts C-I) to obtain the racemic material. The compounds listed in Table 8 were prepared by the methods exemplified in Examples 221-232, 259, 414 and 414A. Table 8 1H-1, 2, 3 -triazolo [4, 5-c] pyri dines: Ar m.p. (°C; 4-Br-2,6-(Me)2-Ph 191-192 2,6-(Me)2-4-SMe-Ph 172-173 2-Cl-4,6-(Me)2-Ph 171-172 2,4-(Cl)2-6-Me-Ph 164-165 2,4-(Me)2-Ph 90-91 2-Me-4-OMe-Ph 104-105 2-Br-4,6-(Me)2-Ph 178-179 4-CN-2, 6- (Cl) 2- h 189-190 3-Br-2,4,6-(Me)3-Ph 156-157 4-Br-2-SMe-Ph 112-114 2-CN-4,6-Me -Ph 181-183 2-Br-5-F-4-Me-Ph 132-134 4-Br-5-F-2-Me-Ph 115-116 2,4-Br 2 -Ph 164-166 4-Ac-2-SMe-Ph 142-144 4-Br-2-Cl-Ph 152-153 2,4-Cl 2 -Ph 134-135 2,4-Me2-6-SMe-Ph 135-136 2,4,6-(Me)3-Ph 117-118 4-Br-2,6-(Me)2-Ph 165-166 2-Cl-4,6-(Me)2-Ph 126-127 3-Br-2,4,6- (Me)3-Ph 117-118 2, 4- (Cl) 2~6-Me-Ph 131-134 2-Br-4,6-(Me)2-Ph 127-128 4-Br-2-Cl-6-Me-Ph 136-137 4-Br-2,6-(Cl)2-Ph 119-120 2,5-Cl 2 -4-N(Me)2-Ph 110-111 2-Me-4,5- (OMe)2-Ph 111-112 4-Cl-2,5-(OMe)2-Ph 167-168 2-Cl-4,5-(Me)2-Ph 169-170 2,6-(Cl)2~4-OMe-Ph 145-146 4-t-Bu-2,6-(Me)2-Ph 134-135 4-Cl-2-Me-5-Nθ2-Ph 163-164 4-Br-2-Cl-5-Me-Ph 159-160 2-Cl-4-OMe-6-Me-Ph 117-118 4-Cl-2,5-Me 2 -Ph 115-116 2-Cl-4-CN-6-Me-Ph 127-128 4-Br-2,6-(Et)2~Ph 168-169 4-Br-2-Cl-6-Me-Ph 104-105 2-Cl-4,6-(OMe)2-Ph 139-140 2-Br-4,6-(OMe)2-Ph 155-156 5-Cl-4-NMe2-2-OMe-Ph 110-111 2,4-(Cl)2-5-CF3-Ph 162-163 4-Cl-2-OMe-5-CF3-Ph 161-162 4-Cl-2-Et-6-Me-Ph 101-103 2-F-4,6-Me 2 -Ph 172-174 2,4-Me 2 -6-SMe-Ph 147-148 2-Br-4,6-Me 2 -Ph 144-147 4-Cl-2,6-Me 2 -Ph 97-100 4-Br-2-Et-6-Me-Ph 111-113 2,4,6-Me 3 -Ph 115-116 4-Br-2, 6-Me 2 -Ph amorph. 4-Br-2-OMe-6-Me-Ph 131-133 2-Cl-4,6-Me 2 -Ph 127-129 2-1-4, 6-Me 2 -Ph 150-152 2-Cl-4-I-6-Me-Ph 119-120 3-F-2,4,6-Me 3 -Ph amorph. 2-Cl-4,6-Me 2 -Ph 127-129 2-Cl-4,6-Me 2 -Ph 108-109 2-Br-6-F-4-Me-Ph 150-152 2-Cl-5-F-4,6-Me 2 -Ph 107-108 3-F-2,4,6-Me 3 -Ph 117-119 3-F-2,4,6-Me 3 -Ph 117-119 2-Cl-5-F-4,6-Me 2 -Ph 107-109 4-Br-2,6-Me -Ph ■4-Br-2, 6-Me 2 -Ph amorph. 2,4,5-Me 3 -Ph oil 2,4,5-Me 3 -Ph oil 2,4,6-Me 3 -Ph 128-130 4-Cl-2,6-Me 2 -Ph 114-115 2,4,6-(Me)3-Ph 55-57 2,4-(Cl)2-6-Me-Ph 64-65 Note: ( + ) , (-), (R) or (S) denotes respective isomers. The compounds listed in table 9 were prepared by the methods exemplified in Examples 209-211 using the intermediate from example 259, part G. Table 9 liϊ-ixnidazo [4, 5-c]pyridines: Ex. No. Ar R 2 R 3 m.p. (°C 524 2-Cl-4,6-(Me)2-Ph H CH(CH2θCH3)2 129-130 525 2-Cl-4,6-(Me)2-Ph Me CH(CH2θCH3)2 156-157 Example 526 This example illustrates an alternative method for making the compound of Example 32. Part A. (±) -l- ethoxy-2-butanol Methanesulfonate (1). A solution of l-methoxy-2- butanol (52.08 g, 57.23 mL, 0.5 mol) and Et3 (108.2 mL, 0.75 mol, 1.5 equiv) in CH2CI2 (500 mL) was treated dropwise with methanesulfonyl chloride (68.73 g, 46.44 mL, 0.6 mol, 1.2 equiv) at 0 °C under N2. The reaction mixture was warmed to 25 °C and stirred at 25 °C for an additional 4 h before being quenched with H2O (300 mL) . The two layers were separated, and the aqueuos was extracted with CH2CI2 (3 x 100 mL) . The combined CH2CI2 extracts were washed with H2O (2 x 200 mL) and saturated aqueuos NaCl (200 mL) , dried (MgSθ4) , and concentrated in vacuo. The residue was dried enough in vacuo to afforded the desired mesylate 1 (85-90.0 g, 91 g theoretical, 93-98%) as a pale-yellow oil, which was pure enough and directly used in the next reaction without further purification. The analytically pure sample of 1 was obtained by silicon-gel column chromatography purification and 1 was obtained as a colorless oil. Part B. (±)-l-Methoxy-2-butyl Azide (2) . A solution of crude mesylate 1 (90.0 g, 0.495 mol) in DMF (500 mL) was treated with aN3 (48.22g, 0.74 mol, 1.5 equiv) at 25 °C under 2. The resulting reaction mixture was warmed to 55-60 °C for 6-8 h with stirring before being quenched with H2O (500 mL) . The pale- yellow solution was then extracted with EtOAc or Et2θ (4 x 200 mL) . The combined EtOAc (or Et2θ) extracts were washed with H2O (3 x 500 mL) , dried (MgSθ4) , and concentrated in vacuo. The residual solution was found to contain desired azide 2 (60.3 g, 64.5 g theoretical, 94%) , which was found to be pure enough and directly used in the following reaction without further purification. The analytically pure sample of 2 was obtained by Siθ2 column chromatography purification as a colorless, low boiling-point liquid. Part C. (±) -4-Amino-5-carbamoyl-l- (1-methoxy -2- )butyl-lJϊ-l,2,3-triazole (3). A suspension of cyanoacetamide (46.5 g, 0.553 mol, 1.2 equiv) in absolute EtOH (200 mL) was treated with EtONa (62.73 g, 0.922 mol, 2.0 equiv) at 25 °C under N2, and the resulting mixture was warmed to reflux for 15 min under N2. The cooled mixture was then treated with a solution of l-methoxy-2-butyl azide 2 (59.5 g, 0.467 mol) in Et2θ and the mixture was diluted with additional EtOH (260 mL) at 25 °C. The resulting reaction mixture was warmed to reflux and stirred for 6-8 h at reflux before being cooled to room tempearture. The solvent was removed in vacuo, and the residue was treated with H2O (300 mL) and EtOAc (300 mL) . The two layers were separated, and the aqueous was extracted with EtOAc (5 x 100 mL) . The combined EtOAc extracts were washed with saturated aqueous NaCl (50 mL) , dried in vacuo, and concentrated in vacuo. The residual yellow solid was directly recrystalized from MeOH (100-150 mL) to afford the desired 1,2,3-triazole 3 (70.7 g, 98.2 g theoretical, 72%) as white crystals. Part D. (±)-9-(l-Methoxy-2-)butyl-2-methyl-8- azaadenine (4). Method A: A solution of 3 (10.65 g, 0.05 mol) in absolute EtOH (50 mL) was treated with EtONa (6.8 g, 0.1 mol, 2.1 equiv) and EtOAc (8.8 g, 10.0 mL, 0.5 mol, 10 equiv) at 25 °C under N2, and the resulting reaction mixture was warmed to reflux with stirring for 6-8 h before being quenched with H2O (50 mL) . The solution was then concentrated in vacuo to remove most of EtOH. The residue was treated with H2O (50 mL) , acidified with concentrated HCl (pH 6-7), and extracted with EtOAc (5 x 50 mL) . The combined EtOAc extracts were washed with saturated aqueous NaCl (20 mL) , dried (MgSθ4) , and concentrated in vacuo. The residual pale-yellow solid was directly recrystalized from 80% EtOAc-Hexane or EtOH to afford 8-azaadenine 4 (8.4 g, 11.85 theoretical, 71%) as white crystals. Method B: A suspension of cyanoacetamide (47.1 g, 0.561 mol, 1.2 equiv) in absolute EtOH (200 mL) was treated with EtONa (95.3 g, 1.4 mol, 3.0 equiv) at 25°C under N2, and the resulting mixture was warmed to reflux for 15 min. under N2. The cooled mixture was then treated with a solution of l-methoxy-2-butyl azide 2 (60.3 g, 0.467 mol) in EtOAc (or Et2θ) in absolute EtOH (170 mL) at 25 °C, and the resulting reaction mixture was warmed to reflux and stirred 4-6 h at reflux before being cooled to RT. EtOAc (120 mL) was added to the reaction mixture, and the resulting mixture was warmed to reflux for an additional 6-10 h. The cooled reaction mixture was treated with H2O (200 mL) , and the solution was concentrated in vacuo to remove most of EtOH. The residue was treated with H2O (100 mL) and acidified with concentrated HCl (pH 6-7) , and extracted with EtOAc (6 x 150 mL) . The combined EtOAc extracts were washed with saturated aqueous NaCl (100 mL) , dried (MgSθ4) , and concentrated in vacuo. The residual pale-yellow solid was recrystalized from 80% EtOAc-Hexane (or EtOH) to afford 8-azaadenine 4 (70.8 g, 110.7 g theoretical, 64% for two steps) as white crystals. Part E. (±)-4-Chloro-l- ( l-methoxy-2- )butyl-2- methyl-8-azaadenine (5) . Method A: A solution of 4 (6.78 g, 0.017 mol) in POCI3 (30 mL) was warmed to reflux for 3 h. The excess POCI3 was removed in vacuo, and the residue was treated with H2O (50 mL) and EtOAc (50 mL) . The two layers were separated, and the aqueous was extracted with EtOAc (3 x 50 mL) . The combined EtOAc extracts were washed with H2O (2 x 50 mL) and saturated aqueous NaCl (30 mL) , dried (MgSθ4), and concentrated in vacuo. Flash chromatography (Siθ2, 10- 20% EtOAc-Hexane gradient elution) afforded 5 (6.65 g, 7.30 g theoretical, 91%) as a colorless oil, which solidified upon standing in vacuo. Method B: A solution of 4 (170 mg, 0.72 mmol) was treated with POCI3 (2 mL) and N, N-diethylaniline (0.5 mL) at 25 °C under Ν2, and the resulting mixture was warmed to reflux for 4-6 h. The excess POCI3 was removed in vacuo, and the residue was directly purified by flash chromatography (Siθ2, 10-20% EtOAc-Hexane gradient elution) to afford 5 (159 mg, 184 mg theoretical, 86%) as a colorless oil, which solidified in vacuo. The product obtained by Method B was identical in all comparable respects with that obtained from Method A. Part P. <±) -1- <l-Methoxy-2-)butyl-2-methyl-4- [ (2, 4, 6-trimethyl)phenyl]a ino-8-azaadenine (6) . A solution of 5 (7.0 g, 0.0274 mol) in toluene (50 mL) was treated with 2, 4, 6-trimethylphenyl amine (8.1 g, mL, 0.06 mol, 2.2 equiv) at 25 °C under N2. The resulting reaction mixture was warmed to reflux for 6-8 h under N2. The white solid (2,4, 6-trimethylaniline HCl salt) was filtered and the solid was washed with toluene (10-20 mL) . The filtrate was concentrated in vacuo. The residual pale-yellow solid was recrystalized from 30% EtOAc-Hexane to afford the title compound 6 (7.9 g, 9.7 g theoretical, 81%) as white crystals. Utility CRF-Rl Receptor Binding Assay for the Evaluation of Biological Activity The following is a description of the isolation of cell membranes containing cloned human CRF- Rl receptors for use in the standard binding assay as well as a description of the assay itself. Messenger RNA was isolated from human hippocampus. The mRNA was reverse transcribed using oligo (dt) 12-18 and the coding region was amplified by PCR from start to stop codons The resulting PCR fragment was cloned into the EcoRV site of pGEMV, from whence the insert was reclaimed using Xhol + Xbal and cloned into the Xhol + Xbal sites of vector pm3ar ( which contains a CMV promoter, the SV40 't* splice and early poly A signals, an Epstein-Barr viral origin of replication, and a hygromycin selectable marker) . The resulting expression vector, called phchCRFR was transfected in 293EBNA cells and cells retaining the episome were selected in the presence of 400 μM hygromycin. Cells surviving 4 weeks of selection in hygromycin were pooled, adapted to growth in suspension and used to generate membranes for the binding assay described below. Individual aliquots containing approximately 1 x 10^ of the suspended cells were then centrifuged to form a pellet and frozen. For the binding assay a frozen pellet described above containing 293EBNA cells transfected with hCRFRl receptors is homogenized in 10 ml of ice cold tissue buffer ( 50 mM HEPES buffer pH 7.0, containing 10 mM MgCl2, 2 mM EGTA, 1 μg/1 aprotinin, 1 μg/ l leupeptin and 1 μg/ml pepstatin) . The homogenate is centrifuged at 40,000 x g for 12 min and the resulting pellet rehomogenized in 10 ml of tissue buffer. After another centrifugation at 40,000 x g for 12 min, the pellet is resuspended to a protein concentration of 360 μg/ml to be used in the assay. Binding assays are performed in 96 well plates; each well having a 300 μl capacity. To each well is added 50 μl of test drug dilutions (final concentration of drugs range from 10- 10 - 10- 5 M) , 100 μl of 125ι_ ovine-CRF ( 125 I-o-CRF) (final concentration 150 pM) and 150 μl of the cell homogenate described above. Plates are then allowed to incubate at room temperature for 2 hours before filtering the incubate over GF/F filters (presoaked with 0.3% polyethyleneimine) using an appropriate cell harvester. Filters are rinsed 2 times with ice cold assay buffer before removing individual filters and assessing them for radioactivity on a gamma counter. Curves of the inhibition of 12 5ι-o-CRF binding to cell membranes at various dilutions of test drug are analyzed by the iterative curve fitting program LIGAND [P.J. Munson and D. Rodbard, Anal. Biochem. 107:220 (1980), which provides Ki values for inhibition which are then used to assess biological activity. A compound is considered to be active if it has a Ki value of less than about 10000 nM for the inhibition of CRF. I nhibi t i on ©_£ CRF - St i mul at ed Adgnv1. af. fi Cv l a.q p Activity Inhibition of CRF-sti ulated adenylate cyclase activity was performed as described by G. Battaglia et al. Synapse 1.-572 (1987). Briefly, assays were carried out at 37° C for 10 min in 200 ml of buffer containing 100 mM Tris-HCl (pH 7.4 at 37° C) , 10 mM MgCl2, 0.4 mM EGTA, 0.1% BSA, 1 mM isobutyl ethylxanthine (IBMX) , 250 units/ml phosphocreatine kinase, 5 mM creatine phosphate, 100 mM guanosine 5'-triphosphate, 100 nM oCRF, antagonist peptides (concentration range 10 "9 to 10 _6m ) and 0.8 g original wet weight tissue (approximately 40-60 mg protein) . Reactions were initiated by the addition of 1 mM ATP/ 32 P]ATP (approximately 2-4 mCi/tube) and terminated by the addition of 100 ml of 50 mM Tris- HCL, 45 mM ATP and 2% sodium dodecyl sulfate. In order to monitor the recovery of cAMP, 1 μl of [ 3 H]cAMP (approximately 40,000 dpm) was added to each tube prior to separation. The separation of [3 p]cAMP from [3 2 P]ATP was performed by sequential elution over Dowex and alumina columns. Recovery was consistently greater than 80%. Some compounds of this invention were tested in this assay and found to be active. Tn vi vo Biological Assay The in vivo activity of the compounds of the present invention can be assessed using any one of the biological assays available and accepted within the art. Illustrative of these tests include the Acoustic Startle Assay, the Stair Climbing Test, and the Chronic Administration Assay. These and other models useful for the testing of compounds of the present invention have been outlined in C.W. Berridge and A.J. Dunn Brain Research Reviews 15:71 (1990) Compounds may be tested in any species of rodent or small mammal. Disclosure of the assays herein is not intended to limit the enablement of the invention. Compounds of this invention have utility in the treatment of inbalances associated with abnormal levels of corticotropin releasing factor in patients suffering from depression, affective disorders, and/or anxiety. Compounds of this invention can be administered to treat these abnormalities by means that produce contact of the active agent with the agent's site of action in the body of a mammal. The compounds can be administered by any conventional means available for use in conjunction with pharmaceuticals either as individual therapeutic agent or in combination of therapeutic agents. They can be administered alone, but will generally be administered with a pharmaceutical carrier selected on the basis of the chosen route of administration and standard pharmaceutical practice. The dosage administered will vary depending on the use and known factors such as pharmacodynamic character of the particular agent, and its mode and route of administration; the recipient's age, weight, and health; nature and extent of symptoms; kind of concurrent treatment; frequency of treatment; and desired effect. For use in the treatment of said diseases or conditions, the compounds of this invention can be orally administered daily at a dosage of the active ingredient of 0.002 to 200 mg/kg of body weight. Ordinarily, a dose of 0.01 to 10 mg/kg in divided doses one to four times a day, or in sustained release formulation will be effective in obtaining the desired pharmacological effect. Dosage forms (compositions) suitable for administration contain from about 1 mg to about 100 mg of active ingredient per unit. In these pharmaceutical compositions, the active ingredient will ordinarily be present in an amount of about 0.5 to 95% by weight based on the total weight of the composition. The active ingredient can be administered orally is solid dosage forms, such as capsules, tablets and powders; or in liquid forms such as elixirs, syrups, and/or suspensions. The compounds of this invention can also be administered parenterally in sterile liquid dose formulations. Gelatin capsules can be used to contain the active ingredient and a suitable carrier such as but not limited to lactose, starch, magnesium stearate, steric acid, or .cellulose derivatives. Similar diluents can be used to make compressed tablets. Both tablets and capsules can be manufactured as sustained release products to provide for continuous release of medication over a period of time. Compressed tablets can be sugar-coated or film-coated to mask any unpleasant taste, or used to protect the active ingredients from the atmosphere, or to allow selective disintegration of the tablet in the gastrointestinal tract. Liquid dose forms for oral administration can contain coloring or flavoring agents to increase patient acceptance. In general, water, pharmaceutically acceptable oils, saline, aqueous dextrose (glucose), and related sugar solutions and glycols, such as propylene glycol or polyethylene glycol, are suitable carriers for parenteral solutions. Solutions for parenteral administration preferably contain a water soluble salt of the active ingredient, suitable stabilizing agents, and if necessary, butter substances. Antioxidizing agents, such as sodium bisulfite, sodium sulfite, or ascorbic acid, either alone or in combination, are suitable stabilizing agents. Also used are citric acid and its salts, and EDTA. In addition, parenteral solutions can contain preservatives such as benzalkonium chloride, methyl- or propyl-paraben, and chlorobutanol. Suitable pharmaceutical carriers are described in "Remington's Pharmaceutical Sciences", A. Osol, a standard reference in the field. Useful pharmaceutical dosage-forms for administration of the compounds of this invention can be illustrated as follows: Capsules A large number of units capsules are prepared by filling standard two-piece hard gelatin capsules each with 100 mg of powdered active ingredient, 150 mg lactose, 50 mg cellulose, and 6 mg magnesium stearate. Soft Gelatin Cansnlfts A mixture of active ingredient in a digestible oil such as soybean, cottonseed oil, or olive oil is prepared and injected by means of a positive displacement was pumped into gelatin to form soft gelatin capsules containing 100 mg of the active ingredient. The capsules were washed and dried. Tablets A large number of tablets are prepared by conventional procedures so that the dosage unit was 100 mg active ingredient, 0.2 mg of colloidal silicon dioxide, 5 mg of magnesium stearate, 275 mg of microcrystalline cellulose, 11 mg of starch, and 98.8 mg lactose. Appropriate coatings may be applied to increase palatability or delayed adsorption. The compounds of this invention may also be used as reagents or standards in the biochemical study of neurological function, dysfunction, and disease.

Claims: Claims: 1. A CRF antagonist compound of formula I or formula II: II or a pharmaceutically acceptable salt or pro-drug form thereof, wherein: X is N or CR 1 ; Y is N or CR 2 ; Z is NR 3 , 0, or S(0) n ; G is 0 or S; Ar is phenyl, naphthyl, pyridyl, pyrimidinyl, triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzthiazolyl, isoxazolyl or pyrazolyl, each optionally substituted with 1 to 5 R^ groups,- R 1 is independently at each occurrence H, Ci- C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, halo, CN, C1-C4 haloalkyl, -NR9R10, NR 9 COR 1 0, -ORH, SH or -S(0) n R 12 ; R 2 is H, C1-C4 alkyl, C1-C6 cycloalkyl, halo, CN, -NR 6 R 7' , NR 9 COR 10 , C1-C4 haloalkyl, -OR 7 , SH or -S ( 0 ) n R 12 ; R 3 is H, C1-C10 alkyl, C2-C10 alkenyl, C2- C10 alkynyl, C3-C8 cycloalkyl or C4- C12 cycloalkylalkyl each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, halo, C1-C4 haloalkyl, cyano, -OR 7 , SH, -Ξ(0) n R 13 , -COR 7 , -C02R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , -CONR 6 R 7 , aryl, heteroaryl and heterocyclyl, where the aryl, heteroaryl or heterocyclyl is optionally substituted with 1 to 3 substituents independently selected at each occurrence from Ci-Cβ alkyl, C3-C6 cycloalkyl, halo, C1-C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 Cθ2R 13 , -NR 6 R 7 , and -CONR 6 R 7 ; R 4 is H, C1-C4 alkyl, allyl, or propargyl, where C1-C4 alkyl, allyl, or propargyl is optionally substituted with C3-C6 cycloalkyl and where C1-C4 alkyl is optionally substituted with, -OR 7 , -S(0) n R 12 or -CO2R 7 ; R 5 is independently at each occurrence C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C6 cycloalkyl, C4-C12 cycloalkylalkyl, -NO2, halo, -CN, C1-C4 haloalkyl, -NR 6 R 7 , NR 8 COR 7 , NR 8 Cθ 2 R 7 , -COR 7 -OR 7 , -CONR 6 R 7 , -CO(NOR 9 )R 7 , CO2R 7 , or -S(0) n R 7 , where C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C6 cycloalkyl and C4- C12 cycloalkylalkyl are optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C4 alkyl, -NO2, halo, -CN, -NR 6 R 7 , -NR 6 R 7 , NR 8 COR 7 , NR 8 C0 2 R 7 , -COR 7 -OR 7 , -CONR 6 R 7 , CO2R 7 , -CO(NOR 9 )R 7 , or -S(0) n R 7 ; R6 and R7 are independently at each occurrence H, C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3-C6 cycloalkyl, C4-C12 cycloalkylalkyl, aryl, aryl(Cχ-C4 alkyl)-, heteroaryl or heteroaryl(C1-C4 alkyl)-; or NR 6 R 7 is piperidine, pyrrolidine, piperazine, N- methylpiperazine, morpholine or thiomorpholine; R 8 is independently at each occurrence H or C1-C4 alkyl; R 9 and R 1 ^ are independently at each occurrence selected from H, C1-C4 alkyl, or C3-C6 cycloalkyl; R 11 is H, C1-C4 alkyl, C1-C4 haloalkyl, or C3-C6 cycloalkyl; R 12 is C1-C4 alkyl or C1-C4 haloalkyl; R 13 is C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3-C6 cycloalkyl, C4- C12 cycloalkylalkyl, aryl, aryl(Cι-C4 alkyl)-, heteroaryl or heteroaryl (C1-C4 alkyl)-; aryl is phenyl or naphthyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from Ci-Ce alkyl, C3-C6 cycloalkyl, halo, C - C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -C02R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , and -CONR β R 7 ; heteroaryl is pyridyl, pyrimidinyl, triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzthiazolyl, isoxazolyl, pyrazolyl, triazolyl, tetrazolyl, or indazolyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, halo, Cι~ C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -C02R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 Cθ2R 13 , -NR 6 R 7 , and -C0NR 6 R 7 ; heterocyclyl is saturated or partially saturated heteroaryl, optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, halo, C1-C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , and -C0NR 6 R 7 ; n is independently at each occurrence 0, 1 or 2; provided that R 4 in formula I is not H: (a) when X is N, Y is N, Z is NR 3 , R 1 is H, R 3 is H or benzyl, and Ar is p-methylphenyl; (b) when X is N, Y is N, Z is NR 3 , R 1 is butyl, R 3 is benzyl, and Ar is phenyl; (c) when X is N, Y is CH, Z is NR 3 , R 3 is methyl, R 1 is H, and Ar is phenyl or 2-fluorophenyl; (d) when X is N, Y is CH, Z is NR 3 , R 3 is methyl, R 1 is Cl and Ar is phenyl; (e) when X is N, Y is CH, Z is NR 3 , R 1 is Cl, R 3 is benzyl, and Ar is phenyl or substituted phenyl; (f) when X is N, Y is CH, Z is NR 3 , R 3 is p- methylbenzyl, and Ar is phenyl; (g) when X is N, Y is CR 2 , Z is NR 3 , R 2 is CH 3 , R 3 is H, and Ar is phenyl or phenyl substituted with methyl, ethyl, isopropyl, fluoro or chloro; (h) when X is N, Y is N, Z is NR 3 , R3 is cyclopropylmethyl, Rl is H, and Ar is 2-bromo-4- isopropylphenyl, or (i) when X is N, Y is N, Z is S, R 1 is H, and Ar is 2-bromo-4-isopropylphenyl. 2. A CRF antagonist compound of claim 1 or a pharmaceutically acceptable salt or pro-drug form thereof, wherein: X. is N or CR 1 ; Y is N or CR 2 ; Z is NR 3 , 0, or S(0) n ; G is 0 or S; Ar is phenyl, pyridyl, each optionally substituted with 1 to 3 R 5 groups; R 1 is independently at each occurrence H, C1-C4 alkyl, halo, CN, C1-C4 haloalkyl, -NR 9 R 10 , -OR 11 or -S(0) n R 12 ; R 2 is H, C1-C4 alkyl, Ci-Ce cycloalkyl, halo, CN, -NR 6 R 7 , NR 9 COR 10 , C1-C4 haloalkyl, -OR 7 or -S(0) n R 12 ; R 3 is H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C - C8 cycloalkyl or C4-C12 cycloalkylalkyl each optionally substituted with 1 to 3 substituents independently selected at each occurrence from Ci- C 6 alkyl, -C -C 6 cycloalkyl, halo, C 1 -C 4 haloalkyl, cyano, -OR 7 , -S(0) n R 13 , -C0 2 R 7 , -NR 8 COR 7 , -NR 8 CONR 6 R 7 , -NR 8 C0 2 R 13 , -NR 6 R 7 , aryl and heteroaryl, where the aryl or heteroaryl is optionally substituted with 1 to 3 substituents independently selected at each occurrence from Ci- C 4 alkyl, halo, cyano, -OR 7 , -S(0) n R 7 , -C0 2 R 7 , -NR 8 C0R 7 , -NR 8 CONR 6 R 7 , -NR 8 C0 2 R 7 , and -NR 6 R 7 ; R 4 is H, C1-C4 alkyl, allyl, or propargyl; R 5 is independently at each occurrence Ci-Cβ alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -Cβ cycloalkyl, C4-C8 cycloalkylalkyl, -N0 2 , halo, -CN C 1 -C 4 haloalkyl, -NR 6 R 7 , COR 7 -OR 7 , -C0NR 6 R 7 , -CO(NOR 9 )R 7 , CO2R 7 , or -S(0) n R 7 / where Cι-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C6 alkynyl, C 3 -C δ cycloalkyl and C4-C12 cycloalkylalkyl are optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C4 alkyl, -N0 2 , halo, -CN, -NR 6 R 7 , COR 7 ' -OR 7 , -CONR 6 R 7 , C0 R 7 , -CO(NOR 9 )R 7 , or -s ( 0 ) n R 7 ; R^ and R7 are independently at each occurrence H, C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3- C6 cycloalkyl, C4-C12 cycloalkylalkyl, aryl, aryl(Ci-C4 alkyl)-, heteroaryl or heteroaryl (C1-C4 alkyl)-; or NR 6 R 7 is piperidine, pyrrolidine, piperazine, N-methylpiperazine, morpholine or thio orpholine; R 8 is independently at each occurrence H or C1-C4 alkyl; R 9 and R 10 are independently at each occurrence selected from H, C1-C4 alkyl, or C3-C6 cycloalkyl; R 11 is H, C1-C4 alkyl, C1-C4 haloalkyl, or C3-C6 cycloalkyl-; R 12 is C1-C4 alkyl or C1-C4 haloalkyl; R 13 C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3-C6 cycloalkyl, C4-C12 cycloalkylalkyl, aryl, aryl(Cι-C4 alkyl)-, heteroaryl or heteroaryl (C1-C4 alkyl) -; aryl is phenyl or naphthyl optionally substituted with 1 to 3 substituents independently selected at each occurrence from C 1 -C 4 alkyl, halo, cyano, -OR 7 , -S(0) n R 12 , -C0 2 R 8 , -NR 8 COR 7 , -NR 8 CONR 6 R 7 , -NR 8 C0 2 R 12 , and -NR 6 R 7 ; heteroaryl is pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, i idazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, isoxazolyl, pyrazolyl, triazolyl, tetrazolyl, or indazolyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C 1 -C 4 alkyl, halo, cyano, -OR 7 , -S(0) n R 12 , -C0 2 R 8 , -NR 8 COR 7 , -NR 8 CONR 5 R 7 , -NR 8 C0 2 R 12 , and -NR 6 R 7 ; n is independently at each occurrence 0, 1 or 2 3. A CRF antagonist compound of claim 1 selected from the group consisting of: N- [2-bromo-4- (1-methylethyl)phenyl] -5-methyl-3-propyl- 3H-1,2, 3-triazolo[4, 5-d]pyrimidin-7-amine N- [2-bromo-4- (Imethylethyl)phenyl] -N-ethyl-5-methyl-3- propyl-3H - 1, 2, 3-triazolo [4, 5-d]pyrimidin-7-amine N- {2-bromo-4- (1-methylethyl)phenyl] -3-butyl-N-ethyl-5- methyl-3H-l, 2, 3.-triazolo[4, 5-d]pyrimidin-7-amine N- [2-bromo-4- (1-methylethyl)phenyl] -3- (cyclopropylmethyl) -N-ethyl-5-methyl-3H-l,2,3- triazolo[4, 5-d] yrimidin-7-amine N- [2-bromo-4- (1-methyl) ethylphenyl] -5-methyl-3- [ (1- methoxymethyl) -2-methoxyethyl) -3H-1, 2, 3-triazolo[4, 5- d]pyrimidin-7-amine N- [2-bromo-4- (1-methylethyl)phenyl] -3- (2-methoxyethyl) - 5-methyl-3H-l, 2, 3-triazolo[4, 5-d]pyrimidin-7-amine N-2-bromo-4- (1-methylethyl)phenyl] -N-ethyl-3- (2- methoxyethyl) -5-methyl-3H-l, 2, 3-triazoloi [4,5- d]pyrimidin-7-amine N- [2-bromo-4- (1-methylethyl)phenyl] -N-ethyl-3- (3- methoxypropyl) -5-methyl-3H-l, 2, 3-triazolo[4, 5-d] pyrimidin-7-amine (+/-) -N- (2-bromo-4- (1-methylethyl)phenyl] -3- [1- (1- methoxymethyl)propyl] -5-methyl-3H-l,2,3-triazolo[4, 5-d] pyrimidin-7-amine (+/-) -N- [2-bromo-4- (1-methylethyl)phenyl] -N-ethyl-3- [1- (1-methoxymethyDpropyl] -5-methyl-3H-l, 2, 3-triazolo[4,5- d] pyrimidin-7-amine (S)-N- [2-bromo-4- (1-methylethyl)phenyl] -3- [1- (1- methoxy ethyl) -2-phenylethyl] -5-methyl-3H-l,2, 3- triazolo[4,5-d] pyrimidin-7-amine (S) -methyl 7 - [2-bromo-4- (1-methylethyl)phenyl] -5- methyl-a-2- (methylthio)ethyl] 3H-1, 2, 3-triazolo[4, 5- d]pyrimidine-3-acetate (+/-)-N- [2-bromo-4-(1-methylethyl) phenyl] 3-1- ethylpentyl] -5-methyl-3H-l, 2, 3-triazolo [4, 5-d]pyrimidin- 7-amine (+/-) -N- [2-bromo-4- (1-methylethyl)phenyl] -N-ethyl-3- [1- ethylpentyl] -5-methyl-3H-1, 2, 3-triazolo[4, 5-d] pyrimidin- 7-amine N- [2-bromo-4- (1-methylethyl)phenyl] -3- [1-propylbutyl] -5- methyl-3H-l,2, 3-triazolo[4, 5-d]pyrimidin-7-amine N- [2-bromo-4- (1-methylethyl)phenyl] -3- [1-butylpentyl] -5- methyl-3H-l, 2, 3-triazolo[4, 5-d]pyrimidin-7-amine (+/-)-N- [2-bromo-4- (1-methylethyl) phenyl] -3- [1- ethylbutyl] -5-methyl-3H-1,2, 3-triazolo[4, 5-d]pyrimidin- 7-amine { + / - ) -!- [2-bromo-4- (1-methylethyl)phenyl] -5-methyl-a- propyl-3H-l,2, 3-triazolo[4, 5-d]pyrimidine-3-ethanol N- [2-bromo-4- (1-methylethyl)phenyl] -3- [1-ethylpropyl] -5- methyl-3H-l, 2, 3-triazolo[4, 5-d]pyrimidin-7-amine N- [2-bromo-4- (1-methylethyl)phenyl] -N-ethyl-3- [1- ethylpropyl] -5-methyl-3H-1, 2, 3-triazolo[4, 5-d]pyrimidin- 7-amine N- (2-bromo-4, 6-dimethylphenyl) -5-methyl-3- [1- propylbutyl] -3H-l,2, 3-triazolo[4, 5-pyrimidin-7-amine 5-methyl-N- [4- (l-methylethyl-2- (methylthio)phenyl] -3- [1- propylbutyl] -3H-l, 2, 3-triazolo[4, 5-d]pyrimidin-7-amine N- [2-bromo-4- (trifluoromethyl)phenyl) ] -5-methyl-3- [1- propylbutyl] -3H-1, 2, 3-triazolo[4, 5-d] yrimidin-7-amine N- [2-bromo-4,6- (dimethoxy)phenyl) ] -5-methyl-3- [1- propylbutyl]-3H-1,2,3-triazolo[4, 5-d]pyrimidin-7-amine N- [ 2 , 6-dimethyl-4- (methylthio)phenyl) ]-5-methyl-3- [1- propylbutyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine N- (4-acetyl-2-bromophenyl)-3- [1-ethylpropyl] -5-methyl- 3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine (+/-)-N- (4acetyl-2-bromophenyl)-3- [1-(1- methoxymethyl)propyl]-5-methyl-3H-l,2,3-triazolo[4,5- d]pyrimidin-7-amine (+/-)-N-(4-bromo-2,6-dimethylphenyl)-3-[l-(l- methoxymethyl)propyl]-5-methyl-3H-l,2,3-triazolo[4,5- d]pyrimidin-7-amine (+/-)-N- [2,6-dimethyl-4- (methylthio)phenyl]-3- [1-(1- methoxymethyDpropyl]-5-methyl-3H-l,2,3-triazolo[4,5- d]pyrimidin-7-amine (+/-)-N- (2-bromo-4,6-dimethoxyphenyl)-3- [1- (1- methoxymethyl)propyl]-5-methyl-3H-l,2,3-triazolo[4,5- d]pyrimidin-7-amine (+/-)-N- (2-chloro-4,6-dimethoxyphenyl)-3-[1-(1- methoxymethylpropyl]-5-methyl-3H-1,2,3-triazolo[4,5- d] yrimidin-7-amine (+/-)-3- [l-(l-methoxymethyl) propyl]-5-methyl-N- (2,4,6- trmethylphenyl)-3H-1,2,3-triazolo[4, 5-d]pyrimidin-7- amine (+/-)-N-ethyl-3- [1- (1-methoxy-methyl)propyl]-5-methyl-N- (2,4, 6-trimethylphenyl) -3H-1,2,3-triazolo[4, 5- d]pyrimidin-7-amine 3- [1- (1-ethyl)propyl] -5-methyl-N- (2,4, 6- trimethylphenyl) -3H-1,2, 3-triazolo[4, 5-d]pyrimidin-7- amine (+/-)-3- [1, (1-ethyl)butyl]-5-methyl-N- (2,4,6- trimethylphenyl) -3H-1,2,3-triazolo[4, 5-d]pyrimidin-7- amine (+/-)-3- [l-(l-ethyl)pentyl]-5-methyl-N-(2,4,6- trimethylphenyl) -3H-1, 2,3-triazolo[4, 5-d]pyrimidine-7- amine 5-methyl-3- [1- (1-propylbutyl] -N- (2,4, 6-trimethylphenyl) 3H-1,2, 3-triazolo[4, 5-d]pyrimidin-7-amine 3- (2-methoxyethyl) -5-methyl-N- (2,4, 6-trimethylphenyl) - 3H-1, 2,3-triazolo[4, 5-d]pyrimidin-7-amine N-ethyl-3- (2-methoxyethyl) -5-methyl-N- (2,4,6- trimethylphenyl) -3H-1,2, 3-triazolo[4, 5-d]pyrimidin-7- a ine N- (2-Methyl-4-bromophenyl)-3- [1- (1-propyl)butyl] -5- methyl-3H-l,2, 3-triazolo[4, 5-d]pyrimidin-7-amine (+/-) -3- [1- (1-ethyl) butyl] -5-methyl-N- (2-methyll-4- bromophenyl) -3H-1, 2, 3-triazolo[4, 5-d]pyrimidin-7-amine (+/-) -N- (4-bromo-2-methylphenyl) -3- [1- (1-methoxymethyl! propyl] -5-methyl-3H-1, 2, 3-triazolo[4, 5-d]pyrimidin-7- a ine (+/-) -3- [l-(1-ethyl)pentyl] -5-methyl-N- [2,4,6- trimethyl)-3-pyridyl-]-3H-l,2,3-triazolo[4,5- d]pyrimidin-7-amine (+/-)-N-ethyl-3-[l- (1-ethyl) pentyl] -5-methyl-N- [2,4, 6- trimethyl) -3-pyridyl-] -3H-1,2, 3-triazolo[4, 5- d]pyrimidin-7-amine (+/-)-3- [1- (l-ethyl)butyl]-5-methyl-N-[ (2,4,6- trimethyl) 3-pyridyl-] -3H-1, 2,3-triazolo[4, 5-d]pyrimidin- 7-amine N-ethyl-3- [1- (1-ethyl) utyl] -5-methyl-N- [2,4,6- trimethyl) -3-pyridyl-] -3H-1,2,3-triazolo[4,5- d]pyrimidin-7-amin 3- [l-(l-propyl)butyl] -5-methyl-N- [ (2,4, 6-trimethyl) -3- pyridyl-] -3H-1,2,3-triazolo[4, 5-d] yrimidin-7-amine N-ethyl-3- [1- (1-propyl) butyl] -5-methyl-N- [2,4,6- trimethyl) -3-pyridyl-] -3H-1, 2,3- riazolo[4, 5- d]pyrimidin-7-amine (+/-)-3- [1-d-methoxymethyD propyl]-5-methyl-N- [2,4, 6- trimethyl) -3-pyridyl-]-3H-1, 2,3-triazolo[4,5- d]pyrimidin-7-amine (+/-)-N-ethyl-3- [1- (1-methoxy methyl) propyl}-5-methyl- N- [ (2,4, 6-trimethyl-3-pyridyl-]-3H-l,2,3-triazolo[4, 5- d] yrimidin-7-amine N-2,4-dibromophenyl) -5-methyl-3- (1-propyl)butyl-3H- 1, 2,3-triazolo[4, 5-d]pyrimidin-7-amine N- [4-acetyl-2-bromphenyl] -5-methyl-3- (l-propyl)butyl-3H- 1,2, 3-triazolo[4, 5-d]pyrimidin-7-amine N- [2-bromo-4- (1-methylethyl) phenyl] -3- [1- (N,N- dimethylamino-methyl) butyl] -5-methyl-3H-1, 2,3- triazolo[4, 5-d]pyrimidin-7-amine N- [2-bromo-4- (1-methylethyl)phenyl] -2-methyl-9- (1- propylbutyl) -9H-purin-6-amine (+/-) -N- [2-bromo-4- (1-methylethyl)phenyl] -9- (1- ethylpentyl) -2-methyl-9H-purin-6-amine (+/-) -N- [2-bromo-4- (trifluoromethyl)phenyl] -9-1- (methoxymethyl)propyl] -2-methyl-9H-purin-6-amine N- [2-bromo-4- (1-methylethyl)phenyl] -N-ethyl-5-methyl- [1,2, 3]thiadiazolo[5, 4-d]pyrimidin-7-amine N- [2-bromo-4- (1-methylethyl)phenyl] -1- (1-ethylpropyl)-6- methyl-lH-1, 2, 3-triazolo[4, 5-c]pyridin-4-amine N- (2-bromo-4, 6-dimethoxyphenyl) -1- (1-ethylpropyl) -6- methyl-lH-1, 2, 3-triazolo[4, 5-c]pyridin-4-amine N- (2-chloro-4, 6-dimethoxyphenyl) -1- (1-ethylpropyl) -6- methyl-lH-1,2, 3-triazolo[4, 5-c]pyridin-4-amine N- (2-bromo-4, 6-dimethoxyphenyl) -6-methyl-l- (1- propylbutyl) -1H-1,2, 3-triazolo[4, 5-c]pyridin-4-amine N- (2-chloro-4, 6-dimethoxyphenyl) -6-methyl-l- (1- propylbutyl) -1H-1,2, 3-triazolo[4, 5-c]pyridin-4-amine (+/-) -N- [2-bromo-4- (1-methylethyl)phenyl] -1- (1- ethylpentyl) -6-methyl-1H-1, 2, 3-triazolo[4, 5-c] pyridin-4- amine (+/-) -N- (2-bromo-4, 6-dimethoxyphenyl) -1- (lethylpentyl) - 6-methyl-lH-l,2, 3-triazolo[4, 5-c]pyridin-4-amine (+/-)-N- (2-chloro-4, 6-dimethoxyphenyl)-l-(1- ethylpentyl) -6-methyl-1H-1, 2, 3-triazolo[4, 5-c] pyridin-4- a ine N- [2-bromo-4- (1-rmethylethyl)phenyl] -6-methyl-l- (1- propylbutyl-lH-1, 2 , 3-triazolo[4, 5-c]pyridin-4-amine N- [4-1-methylethyl)-2-sulfonylmethylphenyl] -6-methyl-l- (1-propylbutyl) -1H-1, 2,3-triazolo [4, 5-c]pyridin-4-amine N- [4- (4-acetyl-2-bromophenyl] -6-methyl-l- (1-propyl- butyl) -lH-l,2,3-triazolo[4, 5-c]pyridin-4-amine N- (2-chloro-4, 6-dimethylphenyl) -1- [1-methoxymethyl- (2- methoxyethyl] -6-methyl-lH-l, 2, 3-triazolo[4, 5- c]pyridin-4-amine Mesylate salt of N- (2-chloro-4, 6-dimethylphenyl) -1- ti¬ methoxymethy1- (2-methoxyethyl] -6-methyl-lH-l,2,3- triazolo [4, 5-c]pyridin-4-amine 6- [N- (2-chloro-4, 6-dimethylphenyl) ] -9- [ (1- methoxymethyDpropyl] -2-methyl-9H-purin-6, 8-diamine (S)- (-) -N- (2-chloro-4, 6-dimethylphenyl] -6-methyl-l- (1- methoxymethyl-3-methoxypropyl) -1H-1, 2, 3-triazolo[4, 5- c]pyridin-4-amine (R,S) -N- (2-chloro-4, 6-dimethylphenyl] -6-methyl-l- (1- methoxymethyl-3-methoxypropyl) -1H-1 ,2, 3-triazolo[4, 5-c] pyridin-4-amine. 4. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 1. 5. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 2. 6. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 3. 7. A method of treating affective disorder, anxiety, depression, irritable bowel syndrome, post-traumatic stress disorder, supranuclear palsy, immune suppression, Alzheimer's disease, gastrointestinal disease, anorexia nervosa or other feeding disorder, drug or alcohol withdrawal symptoms, drug addiction, inflammatory disorder, or fertility problem in a mammal comprising administering to the mammal a therapeutically effective amount of a CRF antagonist compound of formula I or II: or a pharmaceutically acceptable salt or pro-drug form thereof, wherein: X is N or CR 1 ; Y is N or CR 2 ; Z is NR 3 , 0, or S(0) n ; G is 0 or S; Ar is phenyl, naphthyl, pyridyl, pyrimidinyl, triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzthiazolyl, isoxazolyl or pyrazolyl, each optionally substituted with 1 to 5 R^ groups; R 1 is independently at each occurrence H, C]_- C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, halo, CN, C1-C4 haloalkyl, -NR 9 R 10 , NR 9 COR 10 , -OR 11 , SH or -S(0 ) n R 12 ; R 2 is H, C1-C4 alkyl, C1-C6 cycloalkyl, halo, CN, -NR 6 R 7 , NR 9 COR 10 , C1-C4 haloalkyl, -OR 7 , SH or -S ( 0 ) n R 12 ; R 3 is H, C1-C10 alkyl, C2-C10 alkenyl, C2- C10 alkynyl, C3-C8 cycloalkyl or C4- C12 cycloalkylalkyl each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, halo, C1-C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , -CONR 6 R 7 , aryl, heteroaryl and heterocyclyl, where the aryl, heteroaryl or heterocyclyl is optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, halo, C1-C4 haloalkyl, cyano, -OR 7 , SH, -Ξ(0) n R 13 , -COR 7 , -C02R 7 , -OC(0)R l3 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , and -CONR 6 R 7 ; R 4 is H, C1-C4 alkyl, allyl, or propargyl, where C1-C4 alkyl, allyl, or propargyl is optionally substituted with C3-C6 cycloalkyl and where C1-C4 alkyl is optionally substituted with, -OR 7 , -S(0) n R 12 or -CO2R 7 ; R5 is independently at each occurrence C3 . -C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C6 cycloalkyl, C4-C12 cycloalkylalkyl, -NO2, halo, -CN, C1-C4 haloalkyl, -NR 6 R 7 , NR 8 COR 7 , NR 8 C0 2 R 7 , -COR 7 -OR 7 , -CONR 6 R 7 , -C0(N0R 9 )R 7 , CO2R 7 , or -S(0) n R 7 where C1-C10 alkyl, C2-C10 alkenyl, c 2 _ Cιo alkynyl, C3-C6 cycloalkyl and C4- C12 cycloalkylalkyl are optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1.-C4 alkyl, -NO2, halo, -CN, -NR 6 R 7 , -NR 6 R 7 , NR 8 C0R 7 , NR 8 C0 2 R 7 , -COR 7 -OR 7 , -CONR 6 R 7 , CO2R 7 , -CO(NOR 9 )R 7 , or -S(0) n R 7 ; R 6 and R7 are independently at each occurrence H, C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3-C6 cycloalkyl, C4-C12 cycloalkylalkyl, aryl, aryl(Cι-C4 alkyl)-, heteroaryl or heteroaryl (C1-C4 alkyl)-; or NR 6 R 7 is piperidine, pyrrolidine, piperazine, N- ethylpiperazine, morpholine or thiomorpholine; R 8 is independently at each occurrence H or C1-C4 alkyl; R 9 and R 10 are independently at each occurrence selected from H, C1-C4 alkyl, or C3-C6 cycloalkyl; R 11 is H, C1-C4 alkyl, C1-C4 haloalkyl, or C3-C6 cycloalkyl; R 12 is C1-C4 alkyl or C1.-C4 haloalkyl; R 13 is C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3-C6 cycloalkyl, C4- C12 cycloalkylalkyl, aryl, aryl(Cι-C4 alkyl)-, heteroaryl or heteroaryl (C1-C4 alkyl)-; aryl is phenyl or naphthyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from Ci-Cδ alkyl, C3-C6 cycloalkyl, halo, C - C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 C0R 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 Cθ2R 13 , -NR 6 R 7 , and -CONR^R 7 ; heteroaryl is pyridyl, pyrimidinyl, triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzthiazolyl, isoxazolyl, pyrazolyl, triazolyl, tetrazolyl, or indazolyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, halo, Ci- C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -C02R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(C0R 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 Cθ2R 13 , -NR 6 R 7 , and -CONR 6 R 7 ; heterocyclyl is saturated or partially saturated heteroaryl, optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, halo, C1-C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -OC(0)R l3 , -NR 8 C0R 7 , -N(COR 7 ) 2 , -NR 8 CONR6R 7 , -NR 8 C02R 13 , -NR^R 7 , and -CONR 6 R 7 ; n is independently at each occurrence 0, 1 or 2; provided that R 4 in formula I is not H: (a) when X is N, Y is N, Z is NR 3 , R3 is cyclopropylmethyl, Rl is H, and Ar is 2-bromo-4- isopropylphenyl, or (b) when X is N, Y is N, Z is S, R 1 is H, and Ar is 2-bromo-4-isopropylphenyl. 8. A method of treating an affective disorder, anxiety, or depression in a mammal comprising administering to the mammal a therapeutically effective amount of a CRF antagonist compound of claim 2. 9. A method of treating an affective disorder, anxiety, or depression in a mammal comprising administering to the mammal a therapeutically effective amount of a CRF antagonist compound of claim 3. 10. A process for making a 5-amino-4-chloro-6- arylamino-2-substituted pyrimidine of formula VI which comprises reacting a 4, 6-dichloro-5-nitro-2-substituted pyrimidine of formula IV whith an arylamine of formula ArNHR 4 in the presence of a solvent selected from dialkylsulfoxides, dialkylformamides and alkyl alcohols to produce a pyrimidone of formula XIII, reacting the pyrimidone with phosporous oxychloride to produce a 4- chloro-6-arylamino-5-nitro-2-substituted pyrmidine of formula XII, then treating the pyrmidine of formula XII with a reducing agent, as shown in the following scheme: wherein Ar is phenyl, naphthyl, pyridyl, pyrimidinyl, triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzthiazolyl, isoxazolyl or pyrazolyl, each optionally substituted with 1 to 5 R^ groups; R 1 is H, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, halo, CN, C1-C4 haloalkyl, -NR 9 R 10 , NR 9 COR 10 , -OR 11 , SH or -S(0) n R 12 ; R 4 is H, C1-C4 alkyl, allyl, or propargyl, where C1-C4 alkyl, allyl, or propargyl is optionally substituted with C3-C6 cycloalkyl and where C1-C4 alkyl is optionally substituted with, -OR 7 , -S(0) n R 12 or -CO2R 7 ; R5 is independently at each occurrence C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C6 cycloalkyl, C4-C12 cycloalkylalkyl, -NO2, halo, -CN, C1-C4 haloalkyl, -NR 6 R 7 , NR 8 COR 7 , NR 8 C0 2 R 7 , -COR 7 -OR 7 , -CONR 6 R 7 , -CO(NOR 9 )R 7 , CO2R 7 , or -S(0) n R 7 where C1-C10 alkyl, C2-C10 alkenyl, C2- 10 alkynyl, C3-C6 cycloalkyl and C4- C12 cycloalkylalkyl are optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C4 alkyl, -NO2, halo, -CN, -NR 6 R 7 , -NR 6 R 7 , NR 8 COR 7 , NR 8 C0 2 R 7 , -COR 7 -OR 7 , -CONR 6 R 7 , CO2R 7 , -CO(NOR 9 )R 7 , or -S(0) n R 7 ; R 6 and R7 are independently at each occurrence H, C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3-C6 cycloalkyl, C4-C12 cycloalkylalkyl, aryl, aryl (C1-C4 alkyl)-, heteroaryl or heteroaryl(C1-C4 alkyl)-; or NR 6 R 7 is piperidine, pyrrolidine, piperazine, N- methylpiperazine, morpholine or thiomorpholine; R 8 is independently at each occurrence H or C1-C4 alkyl; R 9 and R 10 are independently at each occurrence selected from H, C1-C4 alkyl, or C3-C6 cycloalkyl; R 11 is H, C1-C4 alkyl, C1-C4 haloalkyl, or C3-C6 cycloalkyl; R 12 is C1-C4 alkyl or C1-C4 haloalkyl; R 13 is C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3-C6 cycloalkyl, C4- C12 cycloalkylalkyl, aryl, aryl(Cχ-C4 alkyl)-, heteroaryl or heteroaryl (C1-C4 alkyl)-; aryl is phenyl or naphthyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, halo, Ci- C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 / -COR 7 , -C02R 7 , -OC(0)R 13 , -NR 8 C0R 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , and -CONR 6 R 7 ; heteroaryl is pyridyl, pyrimidinyl, triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzthiazolyl, isoxazolyl, pyrazolyl, triazolyl, tetrazolyl, or indazolyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from Cχ-C6 alkyl, C3-C6 cycloalkyl, halo, Ci- C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , and -C0NR 6 R 7 ; n is independently at each occurrence 0, 1 or 2. 11. A pyrimidone of formula XIII wherein Ar is phenyl, naphthyl, pyridyl, pyrimidinyl, triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzthiazolyl, isoxazolyl or pyrazolyl, each optionally substituted with 1 to 5 R^ groups; R 1 is H, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, halo, CN, C1-C4 haloalkyl, -NR 9 R 1 0, NR 9 COR 10 , -OR 11 , SH or -S(0) n R 12 ; R 4 is H, C1-C4 alkyl, allyl, or propargyl, where C1-C4 alkyl, allyl, or propargyl is optionally substituted with C3-C6 cycloalkyl and where C1-C4 alkyl is optionally substituted with, -OR 7 , -S(0) n R 12 or -CO2R 7 ; R5 is independently at each occurrence Cι-Cχo alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C6 cycloalkyl, C4-C12 cycloalkylalkyl, -NO2, halo, -CN, C1-C4 haloalkyl, -NR 6 R 7 , NR 8 COR 7 , NR 8 C0 2 R 7 , -COR 7 -OR 7 , -CONR 6 R 7 , -CO(NOR 9 )R 7 , CO2R 7 , or -S(0) n R 7 , where Cχ-Cιo alkyl, C2-C10 alkenyl, c 2~Cιo alkynyl, C3-C5 cycloalkyl and C4- C12 cycloalkylalkyl are optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C4 alkyl, -NO2, halo, -CN, -NR 6 R 7 , -MR6 R 7 ( R 8 COR 7 , NR 8 C0 2 R 7 , -COR 7 -OR 7 , -CONR 6 R 7 , CO2R 7 , -CO(NOR 9 )R 7 , or -S(0) n R 7 ; R6 and R7 are independently at each occurrence H, C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3-C6 cycloalkyl, C4-C12 cycloalkylalkyl, aryl, aryl(Cι-C4 alkyl)-, heteroaryl or heteroaryl (C1-C4 alkyl)-; or NR 6 R 7 is piperidine, pyrrolidine, piperazine, N- methylpiperazine, morpholine or thiomorpholine; R 8 is independently at each occurrence H or C1-C4 alkyl; R 9 and R 10 are independently at each occurrence selected from H, C1-C4 alkyl, or C3-C6 cycloalkyl; R 11 is H, C1-C4 alkyl, C1-C4 haloalkyl, or C3-C6 cycloalkyl; R 12 is C1-C4 alkyl or C1-C4 haloalkyl; R 13 is C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3-C6 cycloalkyl, C4- Cl2 cycloalkylalkyl, aryl, aryl(Cι-C4 alkyl)-, heteroaryl or heteroaryl(C1-C4 alkyl)-; aryl is phenyl or naphthyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, halo, Ci- C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(C0R 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , and -C0NR β R 7 ; heteroaryl is pyridyl, pyrimidinyl, triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzthiazolyl, isoxazolyl, pyrazolyl, triazolyl, tetrazolyl, or indazolyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C3.-C6 alkyl, C3-C6 cycloalkyl, halo, Ci- C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 Cθ2R 13 , -NR 6 R 7 , and -CONR 6 R 7 ; n is independently at each occurrence 0, 1 or 2; provided that: when Ar is phenyl substituted with 2 or 3 substituents selected from C 1 -C 4 alkyl, chloro and bro o, or pyridyl substituted with 2 or 3 substituents selected from C 1 -C 4 alkyl, chloro and bromo; and Rl is methyl or ethyl; then R4 is not H or methyl. 12. A method of making a compound of formula XVII by reacting a 4,6-dihydroxy-5-nitropyrimidine with an aryl sulfonic anhydride, aryl sulfonyl chloride, alkyl sulfonic anhydride or alkyl sulfonyl chloride to produce a compound of formula XIV, reacting the latter compound with an amine of the formula R 3 H 2 to produce a compound of formula XV, reacting the latter compound with an arylamine of the formula ArNHR 4 to produce a compound of formula XVI, then treating the latter compound with a reducing agent, as shown in the following scheme: Ar-NHR 4 wherein Ar is phenyl , naphthyl , pyridyl , pyrimidinyl , triazinyl , furanyl , quinolinyl , isoquinolinyl , thienyl , imidazolyl , thiazolyl , indolyl , pyrrolyl , oxazolyl , benzofuranyl , benzothienyl , benzthiazolyl, isoxazolyl or pyrazolyl, each optionall substituted with 1 to 5 R^ groups,- R is the hydrocarbon residue of the aryl or alkyl sulfonic anhydride or sulfonyl chloride; R 1 is H, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, halo, CN, C1-C4 haloalkyl, -NR 9 R 1 0, NR 9 COR 10 , -OR 11 , SH or -S(0) n R 12 ; R 3 is H, C1-C10 alkyl, C2-C10 alkenyl, C2- C10 alkynyl, C3-C8 cycloalkyl or C4- C12 cycloalkylalkyl each optionally substituted with 1 to 3 substituents independently selected at each occurrence from Ci-Cβ alkyl, C3- C6 cycloalkyl, halo, C3 . -C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -C02R 7 , -OC(0)R 13 , -NR 8 C0R 7 , -N(COR 7 ) 2 , -NR 8 C0NR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , -CONR 6 R 7 , aryl, heteroaryl and heterocyclyl, where the aryl, heteroaryl or heterocyclyl is optionally substituted with 1 to 3 substituents independently selected at each occurrence from Ci-Cg alkyl, C3-C6 cycloalkyl, halo, C1-C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , and -CONR 6 R 7 ; R 4 is H, C1-C4 alkyl, allyl, or propargyl, where C3.-C4 alkyl, allyl, or propargyl is optionally substituted with C3-C6 cycloalkyl and where C1-C4 alkyl is optionally substituted with, -OR 7 , -S(0) n R 12 or -CO2R 7 ; R 5 is independently at each occurrence C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C6 cycloalkyl, C4-C12 cycloalkylalkyl, -NO2, halo, -CN, C1-C4 haloalkyl, -NR 6 R 7 , NR 8 COR 7 , NR 8 C0 2 R 7 , -COR 7 : OR 7 ; -CONR 6 R 7 , -CO(NOR 9 )R 7 , CO2R 7 , or -S(0) n R 7 , where C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C6 cycloalkyl and C4- C12 cycloalkylalkyl are optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C4 alkyl, -NO2 , halo, -CN, -NRδR 7 , -NR 6 R 7 , NR 8 COR 7 , NR 8 C0 2 R 7 , -COR 7 -OR 7 , -CONR 6 R 7 , CO2R 7 , -CO(NOR 9 )R 7 , or -S(0) n R 7 ; R 6 and R7 are independently at each occurrence H, C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3-C6 cycloalkyl, C4-C12 cycloalkylalkyl, aryl, aryl(Cχ-C4 alkyl)-, heteroaryl or heteroaryl (C1 . -C4 alkyl)-; or NR 6 R 7 is piperidine, pyrrolidine, piperazine, N- methylpiperazine, morpholine or thiomorpholine; R 8 is independently at each occurrence H or C1-C4 alkyl; R 9 and R 1 ^ are independently at each occurrence selected from H, C1-C4 alkyl, or C3-C6 cycloalkyl; R 11 is H, C1-C4 alkyl, C1-C4 haloalkyl, or C3-C6 cycloalkyl; R 12 is C1-C4 alkyl or C1-C4 haloalkyl; R 13 is C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3-C6 cycloalkyl, C4- C12 cycloalkylalkyl, aryl, aryl(Cι-C4 alkyl)-, heteroaryl or heteroaryl (C1-C4 alkyl)-; alkyl in alkyl sulfonic anhydrides and alkyl sulfonyl chorides is C 1 -C 4 branched or straight chain alkyl optionally substituted with 1 to 3 fluorines; • aryl is phenyl or naphthyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C -Cς, alkyl, C3-C6 cycloalkyl, halo, Cι~ C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , and -CONR 6 R 7 ; heteroaryl is pyridyl, pyrimidinyl, triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzthiazolyl, isoxazolyl, pyrazolyl, triazolyl, tetrazolyl, or indazolyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, halo, Ci- C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , and -CONR 6 R 7 ; heterocyclyl is saturated or partially saturated heteroaryl, optionally substituted with 1 to 3 substituents independently selected at each occurrence from Ci-Cβ alkyl, C3-C6 cycloalkyl, halo, C1-C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , and -C0NR 6 R 7 ; n is independently at each occurrence 0, 1 or 2. 13. A compound of formula XIV or XV: wherein: R is aryl as defined below or is C1-C 4 branched or straight chain alkyl optionally substituted with 1 to 3 fluorines; R 1 is H, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, halo, CN, C1-C4 haloalkyl, -NR 9 R 10 , NR 9 COR 10 , -OR 11 , SH or -S(0) n R 12; R 3 is H, C1-C10 alkyl, C2-C10 alkenyl, C2- C10 alkynyl, C3-C8 cycloalkyl or C4- C12 cycloalkylalkyl each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3- C Q cycloalkyl, halo, C1-C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 r -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 Cθ2R 13 , -NR 6 R 7 , -CONR 6 R 7 , aryl, heteroaryl and heterocyclyl, where the aryl, heteroaryl or heterocyclyl is optionally substituted with 1 to 3 substituents independently selected at each occurrence from Cχ-C6 alkyl, C3-C6 cycloalkyl, halo, C1-C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) / -NR 8 CONR6R 7 ( -NR 8 C02R 13 , -NR^R 7 , and -C0NR β R 7 ; R 6 and R7 are independently at each occurrence H, C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, 3-C6 cycloalkyl, C4-C12 cycloalkylalkyl, aryl, aryl(Cι-C4 alkyl)-, heteroaryl or heteroaryl (-Cι-C4 alkyl)-; or NR 6 R 7 is piperidine, pyrrolidine, piperazine, N- methylpiperazine, morpholine or thiomorpholine; R 8 is independently at each occurrence H or C1-C4 alkyl; R 9 and R 1 ^ are independently at each occurrence selected from H, C1-C4 alkyl, or C3-C6 cycloalkyl; R 11 is H, C1-C4 alkyl, C1-C4 haloalkyl, or C3-C6 cycloalkyl; R 12 is C1-C4 alkyl or C1-C4 haloalkyl; R 13 is C1-C4 alkyl, C1-C4 haloalkyl, C2-C8 alkoxyalkyl, C3-C6 cycloalkyl, C4- # C12 cycloalkylalkyl, aryl, aryl(Cι-C4 alkyl)-, heteroaryl or heteroaryl (C1-C4 alkyl)-; aryl is phenyl or naphthyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, halo, Ci- C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , and -C0NR β R 7 ; heteroaryl is pyridyl, pyrimidinyl, triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, benzthiazolyl, isoxazolyl, pyrazolyl, triazolyl, tetrazolyl, or indazolyl, each optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, halo, Cι_- C4 haloalkyl, cyano, -OR 7 ,- SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) 2 , -NR 8 CONR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , and -CONR 6 R 7 ; heterocyclyl is saturated or partially saturated heteroaryl, optionally substituted with 1 to 3 substituents independently selected at each occurrence from C1-C6 alkyl, C3-C6 cycloalkyl, halo, C1-C4 haloalkyl, cyano, -OR 7 , SH, -S(0) n R 13 , -COR 7 , -CO2R 7 , -OC(0)R 13 , -NR 8 COR 7 , -N(COR 7 ) , -NR 8 CONR 6 R 7 , -NR 8 C02R 13 , -NR 6 R 7 , and -C0NR 6 R 7 ; n is independently at each occurrence 0, 1 or 2.

Inventors: ARVANITIS ARGYRIOS GEORGIOS, BAKTHAVATCHALAM RAJAGOPAL, BECK JAMES PETER, CAIN GARY AVONN, CHORVAT ROBERT JOHN, GILLIGAN PAUL JOSEPH, OLSON RICHARD ERIC, ARVANITIS, ARGYRIOS, GEORGIOS, BAKTHAVATCHALAM, RAJAGOPAL, BECK, JAMES, PETER, CAIN, GARY, AVONN, CHORVAT, ROBERT, JOHN, GILLIGAN, PAUL, JOSEPH, OLSON, RICHARD, ERIC
Applicants: ARVANITIS ARGYRIOS GEORGIOS, BAKTHAVATCHALAM RAJAGOPAL, BECK JAMES PETER, CAIN GARY AVONN, CHORVAT ROBERT JOHN, DU PONT MERCK PHARMA, GILLIGAN PAUL JOSEPH, OLSON RICHARD ERIC, ARVANITIS, ARGYRIOS, GEORGIOS, BAKTHAVATCHALAM, RAJAGOPAL, BECK, JAMES, PETER, CAIN, GARY, AVONN, CHORVAT, ROBERT, JOHN, GILLIGAN, PAUL, JOSEPH, OLSON, RICHARD, ERIC, THE DU PONT MERCK PHARMACEUTICAL COMPANY
Application year: 1997
Main classification: A61K
IPC codes: A61K31, A61P1, A61P15, A61P25, A61P29, A61P37, A61P43, C07D239, C07D471, C07D473, C07D487, C07D513