Process for producing 6-methyl-2-heptanone analogues, and process for producing phyton and isophytol

Abstract: Provided are a process for producing 6-methyl-3-hepten-2-one by cross aldol condensation carried out while each continuously adding to acetone, isovaleraldehyde and an aqueous alkali containing an alkaline substance; a process for producing a 6-methyl-2-heptanone analogue represented by Formula (1): wherein n is an integer of 0 or 1 or more; which comprises allowing hydrogen, acetone and an aldehyde represented by Formula (2): wherein n is as defined above; X and Y each represents a hydrogen atom or they are coupled together to form a carbon-carbon bond; and Z and W each represents a hydrogen atom or they are coupled together to form a carbon-carbon bond; to react in the presence of an aqueous alkali containing an alkaline substance, and a hydrogenation catalyst; and a process for producing phyton or isophytol using the 6-methyl-3-hepten-2-one or the 6-methyl-2-heptanone analogue.

Description: This invention relates to a process for producing in an industrially simple manner 6-methyl-2-heptanone analogues (e.g., 6-methyl-2-heptanone or 6,10-dimethyl-2-undecanone), which serve as materials for producing phyton or isophytol. This invention also relates to a process for producing phyton or isophytol from the 6-methyl-2-heptanone analogue. As well known, phyton and isophytol are compounds useful as intermediates for producing biologically active substances such as vitamin E [see Yuki Gosei Kagaku Kyokaishi, 20 , 824-836 (1962)] and can be produced by various processes. From the viewpoint of industrial application, a process is considered to be favored in which a ketone having 8 carbon atoms represented by the following Formula (I) (the dotted line in the Formula means that one or two carbon-carbon double bond(s) can be present so long as the valence of carbon at the position indicated by such double bond(s) is satisfied) is used as an intermediate (hereinafter the ketone represented by Formula (I) is referred to as "C8 terpene ketone". Here, in an instance, the whole process for producing phyton and isophytol where 6-methyl-5-hepten-2-one is used as the C8 terpene ketone will be shown by the following scheme. Thus, in the process for producing phyton or isophytol from the C8 terpene ketone, it basically proceeds that the principal carbon chain of the C8 terpene ketone is several times made longer by five carbons corresponding to the isoprene unit, followed by hydrogenation of the carbon-carbon double bond in the resulting compound. This basic procedure is not different whether or not unsaturated bonds are present, and at whatever positions they are, in the C8 terpene ketone. Accordingly, in the process for producing phyton or isophytol from C8 terpene ketone, how to produce the intermediate C8 terpene ketone with ease and at a low cost is one of important factors for the industrial application. In this regard, as processes for producing the C8 terpene ketone, those shown below are known, for example. Process (i): A process in which acetone ,the starting material, is subjected to ethynylation by acetylene in the presence of an alkaline catalyst to form 3-methyl-1-butyn-3-ol and successive partial hydrogenation in the presence of a Lindlar catalyst, followed by reaction with diketene to form an ester derivative of acetoacetic acid. Thereafter, the ester thus formed is further subjected to Carroll rearrangement to produce 6-methyl-5-hepten-2-one [see, e.g., J. Org. Chem., 23 , 153 (1958); Zh. Obshch. Chim., 28 , 1444 (1958)]. Process (ii): A process in which isobutene, acetone and formaldehyde are allowed to react under conditions of a high temperature and a high pressure to give 6-methyl-6-hepten-2-one (see, e.g., German Patents No. 12 59 876 and No. 12 68 135 and U.S. Patent No. 3,574,773). Process (iii): A process in which prenyl chloride obtained by the reaction of isoprene with hydrogen chloride is allowed to react with acetone in the presence of an equimolar amount of an alkali based on the prenyl chloride to give 6-methyl-5-hepten-2-one (see, e.g., U.S. Patents No. 3,983,175 and No. 3,984,475). These processes for producing C8 terpene ketone, however, have problems as stated below. The process (i) has a problem that it requires many steps resulting in a higher production cost. The process (ii) has a problem that it requires special manufacturing equipments because the reaction is carried out under conditions of a high temperature and a high pressure. In the process (iii), the use of an alkali in an equimolar amount based on the prenyl chloride results in the formation of a salt in a large quantity to make it necessary to take much labor for its disposal. 6-Methyl-2-heptanone is not only useful as a material for producing phyton and isophytol as previously stated, which are intermediates for producing vitamin E, but also useful as a material for producing perfumes such as tetrahydrolinalool and dihydrogeraniol [see, e.g., Bull. Soc. Chim. Fr., 1586 (1955)]. As conventional processes for producing 6-methyl-2-heptanone, processes (iv) to (ix) shown below are known. Process (iv): A process in which an isoamyl halide and an acetoacetic acid ester are subjected to condensation reaction under alkaline conditions, followed by hydrolysis and then decarboxylation (see, e.g., Wagner, "SYNTHETIC ORGANIC CHEMISTRY", p.327, John Wiley & Sons, Inc.). Process (v): A process in which 6-methyl-5-hepten-2-one or 6-methyl-3,5-heptadien-2-one is subjected to hydrogenation in the presence of a hydrogenation catalyst such as Pd or Ni [see, e.g., European Patent No. 34,804; J. Org. Chem., 42 , 1709 (1977); Izv. Akad. Nauk. SSSR. Khim., 10 , 2381 (1972)]. Process (vi): A process in which 6-methyl-2-heptanol is oxidized [see, e.g., Recl. Trav. Chim. Pays-Bas, 28 , 116 (1909)]. Process (vii): A process in which 6-methyl-5-hepten-2-ol is treated with a mixture of 85% phosphoric acid and phosphorus pentoxide [see, Bull. Soc. Chim. Fr., 1799 (1963)]. Process (viii): A process in which methyl vinyl ketone is subjected to 1,4-addition with an isobutyl magnesium halide [see, Bull. Chem. Soc. Jpn., 38 , 29 (1965)]. Process (ix): A process in which isovaleraldehyde and acetone are allowed to react under a stream of hydrogen, in the presence of a catalyst comprised of a metal oxide and a metal belonging to Group VIII of the periodic table (See U.S. Patents No. 4,146,581 and No. 4,212,825). The above processes, however, have problems as discussed below. In the process (iv), a base is used in an equimolar amount based on the acetoacetic acid ester, so a salt is formed in a large quantity to require much labor for its disposal, resulting in a high cost for the production of the 6-methy-2-heptanone. In the processes (v) and (vi), the production of 6-methyl-5-hepten-2-one, 6-methyl-3,5-heptadien-2-one or 6-methyl-2-heptanol, the starting material, is complicated because many steps are required from inexpensive and readily available materials. In the process (vii), not only the production of the 6-methyl-5-hepten-2-ol is complicated because many steps are required from inexpensive and readily available materials, but also the 85% phosphoric acid and phosphorus pentoxide are used in a large quantity to require much labor for the disposal of waste water. In the process (viii), the isobutyl magnesium halide is used in an equimolar amount based on the methyl vinyl ketone, so a salt is formed in a large quantity to require much labor for its treatment, resulting in a high production cost. Moreover, methyl vinyl ketone, one of the materials, has so high a tendency to polymerization and also the other isobutyl magnesium halide is so sensitive to water and oxygen that they must be handled with care. In the process (ix), the reaction is carried out under conditions of a high temperature and a high pressure, so it requires a special manufacturing equipment. The above conventional processes for producing 6-methyl-2-heptanone have subjects to be settled in view of production cost and manufacturing equipment. Thus, no industrially advantageous process has been established for producing the 6-methyl-2-heptanone. Besides the 6-methyl-2-heptanone, as intermediates for producing phyton or isophytol, one may contemplate making use of 6-methyl-2-heptanone analogues having 6-methyl-2-heptanon-7-yl residual groups, such as 6,10-dimethyl-2-decanone and 6,10,14-trimethyl-5,9-pentadecadien-2-one. Production processes for these, however, also is considered to have similar problems. The present invention aims at solving the problems discussed above. Accordingly, it is an object of the present invention to provide a process for producing, in an efficient and industrially simple manner, 6-methyl-2-heptanone and analogues thereof (e.g., 6-methyl-2-heptanone and 6,10-dimethyl-2-undecanone; the 6-methyl-2-heptanone and analogues thereof are herein simply called "6-methyl-2-heptanone analogues" as a whole) which can be used as materials for producing phyton or isophytol. The object of the present invention can be achieved by a production process according to a first embodiment of the present invention, i.e., a process for producing a 6-methyl-2-heptanone analogue represented by Formula (1), including the 6-methyl-2-heptanone: wherein n is an integer of 0 or 1 to 4; the process comprising the step of allowing hydrogen, acetone and an aldehyde represented by Formula (2) : wherein n is as defined above; X and Y each represents a hydrogen atom or they are coupled together to form a carbon-carbon bond; and Z and W each represents a hydrogen atom or they are coupled together to form a carbon-carbon bond; to react in the presence of an aqueous alkali containing an alkaline substance, and a hydrogenation catalyst. A further object of the present invention can be achieved by a production process according to a second embodiment of the present invention, i.e., a process for producing phyton, comprising the following steps (a) to (f): Step (a): Forming 6-methyl-2-heptanone by the process as defined above [n = 0 in the compound of Formula (1)], wherein at least one of senecioaldehyde and isovaleraldehyde is used as the aldehyde of Formula (2); step (b): allowing the 6-methyl-2-heptanone obtained in the step (a) to react with a vinyl magnesium halide to effect vinylation, or subjecting the 6-methyl-2-heptanone to ethynylation and successive partial hydrogenation, to form 3,7-dimethyl-1-octen-3-ol; step (c): allowing the 3,7-dimethyl-1-octen-3-ol obtained in the step (b) to react with diketene or an acetoacetic acid ester to form an acetoacetic acid ester of 3,7-dimethyl-1-octen-3-ol and subjecting the resultant ester to Carroll rearrangement, or allowing the 3,7-dimethyl-1-octen-3-ol to react with an isopropenyl alkyl ether to form an isopropenyl ether of 3,7-dimethyl-1-octen-3-ol and subjecting the resultant ether to Claisen rearrangement, to give 6,10-dimethyl-5-undecen-2-one; step (d): allowing the 6,10-dimethyl-5-undecen-2-one obtained in the step (c) to react with a vinyl magnesium halide to effect vinylation, or subjecting the 6,10-dimethyl-5-undecen-2-one to ethynylation and successive partial hydrogenation, to form 3,7,11-trimethyl-1,6-dodecadien-3-ol; step (e): allowing the 3,7,11-trimethyl-1,6-dodecadien-3-ol obtained in the step (d) to react with diketene or an acetoacetic acid ester to form an acetoacetic acid ester of 3,7,11-trimethyl-1,6-dodecadien-3-ol and subjecting the resultant ester to Carroll rearrangement, or allowing the 3,7,11-trimethyl-1,6-dodecadien-3-ol to react with an isopropenyl alkyl ether to form an isopropenyl ether of 3,7,11-trimethyl-1,6-dodecadien-3-ol and subjecting the resultant ether to Claisen rearrangement, to give 6,10,14-trimethyl-5,9-pentadecadien-2-one; and step (f): subjecting the 6,10,14-trimethyl-5,9-pentadecadien-2-one obtained in the step (e) to hydrogenation to form phyton. In this process, isophytol can be obtained by providing the step (step (g)) of allowing the obtained phyton to react with a vinyl magnesium halide to effect vinylation, or by subjecting the phyton to ethynylation and successive partial hydrogenation, to form isophytol. These and other objects, features and benefits of the present invention are described in or will become apparent from the following detailed description of the invention. The present invention will be described below in detail. It is commonly known as aldol reaction that carbonyl compounds such as aldehydes or ketones undergo condensation in the presence of a basic catalyst to form aldols or ketols. For example, isovaleraldehyde or acetone readily undergoes self aldol condensation in the presence of a basic catalyst to form the corresponding aldol or ketol, respectively, followed by intramolecular dehydration to give an α,β-unsaturated carbonyl compound as an aldol condensate (see, e.g., "ORGANIC REACTIONS" Vol. 16, pages 88 and 112, John Wiley & Sons, Inc.). Such an α, β-unsaturated carbonyl compound can be converted into further condensate easily by the aldol reaction. Aldol reaction between different two carbonyl compounds is also known as cross aldol condensation. In the cross aldol condensation, a variety of products are formed in most cases, and it is usually difficult to selectively obtain an aldol condensate in which the two different carbonyl compounds have condensed one by one (hereinafter referred to as "cross aldol condensate"). Accordingly, in the cross aldol condensation, in order to improve the selectivity of the cross aldol condensate on the basis of one of the two different carbonyl compounds, the other carbonyl compound is commonly used in excess. However, in the case of aldol condensation, which is conventionally carried out, the basic catalyst is present in the reaction mixture at the start of the reaction, so that the formation of a self aldol condensate of the excessive carbonyl compound is involved to reduce the yield of the desired cross aldol condensate, make it difficult to isolate the cross aldol condensate and also result in contamination by impurities in a large quantity. Next, the second embodiment of the present invention that achieves the further object of the present invention will be described below. The second embodiment of the present invention is a process for producing phyton in which the production process of the first embodiment is included as the first step, and comprises the following steps: Step (a) : the step of forming 6-methyl-2-heptanone by the process according to the first embodiment of the present invention [n = 0 in the compound of Formula (1)], wherein at least one of senecioaldehyde and isovaleraldehyde is used as the aldehyde of Formula (2); step (b) : the step of allowing the 6-methyl-2-heptanone obtained in the step (a) to react with a vinyl magnesium halide to effect vinylation, or subjecting the 6-methyl-2-heptanone to ethynylation and successive partial hydrogenation, to form 3,7-dimethyl-1-octen-3-ol; step (c): the step of allowing the 3,7-dimethyl-1-octen-3-ol obtained in the step (b) to react with a diketene or an acetoacetic acid ester to form an acetoacetic acid ester of 3,7-dimethyl-1-octen-3-ol and subjecting the resultant ester to Carroll rearrangement, or allowing the 3,7-dimethyl-1-octen-3-ol to react with an isopropenyl alkyl ether to form an isopropenyl ether of 3,7-dimethyl-1-octen-3-ol and subjecting the resultant ether to Claisen rearrangement, to give 6,10-dimethyl-5-undecen-2-one; step (d): the step of allowing the 6,10-dimethyl-5-undecen-2-one obtained in the step (c) to react with a vinyl magnesium halide to effect vinylation, or subjecting the 6,10-dimethyl-5-undecen-2-one to ethynylation and successive partial hydrogenation, to form 3,7,11-trimethyl-1,6-dodecadien-3-ol; step (e): the step of allowing the 3,7,11-trimethyl-1,6-dodecadien-3-ol obtained in the step (d) to react with a diketene or an acetoacetic acid ester to form an acetoacetic acid ester of 3,7,11-trimethyl-1,6-dodecadien-3-ol and subjecting the resultant ester to Carroll rearrangement, or allowing the 3,7,11-trimethyl-1,6-dodecadien-3-ol to react with an isopropenyl alkyl ether to form an isopropenyl ether of 3,7,11-trimethyl-1,6-dodecadien-3-ol and subjecting the resultant ether to Claisen rearrangement, to give 6,10,14-trimethyl-5,9-pentadecadien-2-one; and step (f): the step of subjecting the 6,10,14-trimethyl-5,9-pentadecadien-2-one obtained in the step (e) to hydrogenation to form phyton (6,10,14-trimethylpentadecan-2-one). The production process according to the second embodiment of the present invention can also be a process for producing isophytol by providing, subsequent to the above step (f): step (g): the step of allowing the phyton formed in the step (f) to react with a vinyl magnesium halide to effect vinylation, or by subjecting the phyton to ethynylation and successive partial hydrogenation, to form isophytol. In the second embodiment of the present invention, the 6-methyl-2-heptanone, a kind of the C8 terpene ketones, obtained through the step (a) can be produced from inexpensive and readily available materials under mild production conditions and in a higher yield than the C8 terpene ketones obtained by the processes (i) to (iii) and (iv) to (ix), so that the phyton and isophytol can be produced in an industrially advantageous manner. The process for producing phyton or isophytol according to the second embodiment of the present invention will be detailed below in the order of steps. Step (a): This step (a) is identical with the production process according to the first embodiment of the present invention, thus all the details given for the latter as described below are common to the former. Step (b): In the step (b), 3,7-dimethyl-1-octen-3-ol is formed from the 6-methyl-2-heptanone obtained in the step (a), by adding a vinyl group (-CH 2 =CH 2 ) to the carbonyl group at its terminal. As a method for the step (b), either method is selected from a method in which the 6-methyl-2-heptanone is allowed to react with a vinyl magnesium halide to effect vinylation, or a method in which the 6-methyl-2-heptanone is subjected to ethynylation and successive partial hydrogenation. For the industrial application, it is more advantageous to effect the latter ethynylation and successive partial hydrogenation. In the former method, in which the 6-methyl-2-heptanone is allowed to react with a vinyl magnesium halide, 3,7-dimethyl-1-octen-3-ol can be obtained by, e.g., adding the 6-methyl-2-heptanone to a vinyl magnesium halide prepared from a vinyl halide such as vinyl chloride or vinyl bromide and metal magnesium in a solvent such as tetrahydrofuran or diethyl ether, in such an amount of from 0.5 to 2 moles per mole of the vinyl magnesium halide to carry out reaction at a temperature of usually from -10 to 55°C, and preferably from 0 to 40°C, followed by hydrolysis using dilute aqueous sulfuric acid, a saturated aqueous ammonium chloride or the like. In the latter method, in which the 6-methyl-2-heptanone is subjected to ethynylation and successive partial hydrogenation, the 6-methyl-2-heptanone is first ethynylated by a conventional method to form 3,7-dimethyl-1-octyn-3-ol, having 10 carbon atoms and having a carbon-carbon triple bond at the terminal. Here, the ethynylation can be carried out by a known process as a process in which ketones are ethynylated to form compounds having a propargyl alcohol structure (see U.S. Patents No. 3,082,260 and No. 3,496,240; Japanese Patent Application Laid-open No. sho50-59308,etc.). When the ethynylation is carried out in a small scale, it is also possible to use a method with an acetylide of an alkali metal such as lithium, sodium or potassium or an alkaline earth metal such as calcium [see Org. Synth., 3 , 416 (1955)] or a method with an ethynyl magnesium halide [see Org. Synth., 4 , 792 (1963)]. When the ethynylation is carried out in an industrial scale, it is suitable to use, as described below, a method of direct ethynylation by acetylene in the presence of a strong base, because 3,7-dimethyl-1-octyn-3-ol can be produced at a low production cost and the work up can be made easily. This direct ethynylation is carried out by a process in which the 6-methyl-2-heptanone is allowed to react with acetylene, usually in an amount of from 1 to 10 moles per mole of the former, at -30°C to 30°C for 1 hour to 20 hours. The reaction is carried out under conditions where a strong base containing an alkali metal such as sodium or potassium (e.g., a hydroxide of the alkali metal, an alkali metal alcoholate or an alkali metal amide) is present in a catalytic amount, and in an organic solvent which does not inhibit the reaction such as N,N-dimethylformamide, dimethyl sulfoxide, N-methylpyrrolidone, tetrahyrofuran, dimethyl ether, diethyl ether, methyl ethyl ether, anisole or dioxane, or liquid ammonia, or a mixed solvent of these. After the reaction, the acetylene is purged off from the reaction vessel, and 3,7-dimethyl-1-octyn-3-ol is obtained as a residue. Next, the 3,7-dimethyl-1-octyn-3-ol obtained as described above is partially hydrogeneated to give the 3,7-dimethyl-1-octen-3-ol. This partial hydrogenation intends to selectively reduce the carbon-carbon triple bond to a carbon-carbon double bond, and methods therefor are known per se. As methods for selectively reduce carbon-carbon triple bonds to the carbon-carbon double bonds, a method in which a hydrogenating agent such as lithium aluminum hydride is used [see J. Chem. Soc., 1854 (1954)] and a method in which a propargyl type alcohol is catalytically reduced in the presence of a hydrogenation catalyst in a solvent of a hydrocarbon such as n-hexane, n-heptane, octane, benzene, toluene or xylene and/or an alcohol such as, methanol, ethanol or propanol [see Org. Synth., 5 , 880 (1973)] can be exemplified. From an industrial viewpoint, the latter method is preferred. The hydrogenation of 3,7-dimethyl-1-octen-3-ol is carried out, e.g., in an atmosphere of hydrogen, at a hydrogen pressure of from normal pressure to 49.05 bar (50 kg/cm 2 ), and preferably from 1.962 to 19.62 bar (2 to 20 kg/cm 2 ), and at a temperature of from 0 to 130°C, and preferably from 20 to 80°C. As the hydrogenation catalyst, a metal such as nickel, cobalt, palladium, platinum, rhodium or iridium or a compound containing these metal can be used. These can be supported on carriers such as activated carbon, barium sulfonate and calcium carbonate. In particular, in the present invention, a Lindlar catalyst comprising palladium supported on calcium carbonate is especially preferable. After the reaction is completed, 3,7-dimethyl-1-octen-3-ol can be isolated from the reaction mixture by a conventional method, e.g., by distillation. Step (c): In the step (c), 6,10-dimethyl-5-undecen-2-one is formed from the 3,7-dimethyl-1-octen-3-ol obtained in the step (b). As a method for the step (c), either method is selected from a method in which the 3,7-dimethyl-1-octen-3-ol is allowed to react with diketene or an acetoacetic acid ester to form an acetoacetic acid ester of 3,7-dimethyl-1-octen-3-ol and subjecting the resultant ester to Carroll rearrangement, or a method in which the 3,7-dimethyl-1-octen-3-ol is allowed to react with an isopropenyl alkyl ether to form an isopropenyl ether of 3,7-dimethyl-1-octen-3-ol and subjecting the resultant ether to Claisen rearrangement. In the former method, which employs Carroll rearrangement, first, the acetoacetic acid ester of 3,7-dimethyl-1-octen-3-ol is formed by allowing 3,7-dimethyl-1-octen-3-ol to react with diketene usually in an amount of from 0.8 to 2 moles, and preferably from 0.9 to 1.2 moles, per mole of the former. In this instance, the acetoacetic acid ester can be formed by merely making the 3,7-dimethyl-1-octen-3-ol contact with the diketene without a solvent or in an organic solvent which does not inhibit the reaction such as hydrocarbons or ethers. If necessary, the reaction can be conducted with heating to from 50 to 100°C. Also, an amine such as triethylamine or pyridine can be added in a catalytic amount to the reaction mixture, which accelerates the rate of esterification and improves the yield of the acetoacetic acid ester of 3,7-dimethyl-1-octen-3-ol. Next, the acetoacetic acid ester of 3,7-dimethyl-1-octen-3-ol thus obtained is heated to usually from 130 to 180°C, and preferably from 150 to 180°C, in order to make the Carroll rearrangement (rearrangement and successive decarboxylation) proceed to give 6,10-dimethyl-5-undecen-2-one. At this step, an aluminum alkoxide such as aluminum isopropoxide can be added in a catalytic amount of the reaction mixture, which improves the yield of the 6,10-dimethyl-5-undecen-2-one. Also 6,10-dimethyl-5-undecen-2-one can be obtained from the 3,7-dimethyl-1-octen-3-ol and diketene in one pot by mixing the reactants necessary for the above two-step reaction (esterification and Carroll rearrangement) all at once and controlling the reaction temperature. In the foregoing, the reaction can be carried out under similar conditions when an acetoacetic acid ester such as methyl acetoacetate or ethyl acetoacetate is used in place of the diketene, and the similar results as in the foregoing can be obtained. These reaction and their mechanism are described in the literature [See e.g., J. Chem. Soc. 704 (1940); Japanese Patent Publications No. sho32-8616 and No. sho49-25251; British Patent No. 907,142, etc.] Meanwhile, in the latter method, which employs Claisen rearrangement, the mixture of 3,7-dimethyl-1-octen-3-ol and an isopropenyl alkyl ether such as isopropenyl methyl ether or isopropenyl ethyl ether in an amount of from 0.5 to 10 moles, and preferably from 0.8 to 3 moles, per mole of the former are heated at a temperature of from 50 to 200°C, and preferably from 100 to 200°C, in the presence of an acidic catalyst such as phosphoric acid, sulfuric acid, oxalic acid or trichloroacetic acid to effect isopropenyl etherification of the 3,7-dimethyl-1-octen-3-ol, and the resultant ether is converted into 6,10-dimethyl-5-undecen-2-one by Claisen rearrangement [see, e.g., Japanese Patent Publication No. sho40-23328]. After the reaction is completed, 6,10-dimethyl-5-undecen-2-one can be isolated from the reaction mixture by a conventional method, e.g., by distillation. Step (d): In the step (d), 3,7,11-trimethyl-1,6-dodecadien-3-ol is formed from the 6,10-dimethyl-5-undecen-2-one obtained in the step (c), by adding a vinyl group to the carbonyl group at its terminal. As a method for the step (d), either method is selected from a method in which the 6,10-dimethyl-5-undecen-2-one is allowed to react with a vinyl magnesium halide to effect vinylation, or a method in which the 6,10-dimethyl-5-undecen-2-one is subjected to ethynylation and successive partial hydrogenation. From the industrial application, the latter method in which the 6,10-dimethyl-5-undecen-2-one is subjected to ethynylation and successive partial hydrogenation is more advantageous. This step (d) can be carried out following the procedure described in the step (b). More specifically, in the former method, in which 6,10-dimethyl-5-undecen-2-one is allowed to react with a vinyl magnesium halide, the 3,7,11-trimethyl-1,6-dodecadien-3-ol can be obtained by, e.g., adding the 6,10-dimethyl-5-undecen-2-one to a vinyl magnesium halide prepared from a vinyl halide such as vinyl chloride or vinyl bromide and metal magnesium in a solvent such as tetrahydrofuran or diethyl ether, in such an amount of from 0.5 to 2 moles per mole of the vinyl magnesium halide to carry out reaction at a temperature of usually from -10 to 55°C, and preferably from 0 to 40°C, followed by hydrolysis using a dilute aqueous sulfuric acid, a saturated aqueous ammonium chloride or the like. In the latter method, in which the 6,10-dimethyl-5-undecen-2-one is subjected to ethynylation and successive partial hydrogenation, the 6,10-dimethyl-5-undecen-2-one is first ethynylated by a conventional method to form 3,7,11-trimethyl-6-dodecen-1-yn-3-ol, having 15 carbon atoms and having a carbon-carbon triple bond at the terminal. Here, the ethynylation can be carried out by a known process as a process in which ketones are ethynylated to form compounds having a propargyl alcohol structure. When the ethynylation is carried out in a small scale, it is also possible to use a method with an acetylide of an alkali metal such as lithium, sodium or potassium or an alkaline earth metal such as calcium, or a method with an ethynyl magnesium halide. When the ethynylation is carried out in an industrial scale, it is suitable to use, as described below, a method of direct ethynylation by acetylene in the presence of a strong base, because 3,7,11-trimethyl-6-dodecen-1-yn-3-ol can be produced at a low cost and the work up can be made easily. This direct ethynylation is carried out by a process in which the 6,10-dimethyl-5-undecen-2-one is allowed to react with acetylene, usually in an amount of from 1 to 10 moles per mole of the former, at -30°C to 30°C for 1 hour to 20 hours. The reaction is carried out under conditions where a strongly base compound containing an alkali metal such as sodium or potassium (e.g., a hydroxide of the alkali metal, an alkali metal alcoholate or an alkali metal amide) is present in a catalytic amount, and in an organic solvent which does not inhibit the reaction such as N,N-dimethylformamide, dimethyl sulfoxide, N-methylpyrrolidone, tetrahyrofuran, dimethyl ether, diethyl ether, methyl ethyl ether, anisole or dioxane, or liquid ammonia, or a mixed solvent of these. After the reaction, the acetylene is purged off from the reaction vessel, and 3,7,11-trimethyl-6-dodecen-1-yn-3-ol is obtained as a residue. Next, the 3,7,11-trimethyl-6-dodecen-1-yn-3-ol obtained as described above is partially hydrogenated to give 3,7,11-trimethyl-1,6-dodecadien-3-ol. This partial hydrogenation intends to selectively reduce the carbon-carbon triple bond to a carbon-carbon double bond, and methods therefor are known per se. As methods for such reduction, a method in which a hydrogenating agent such as lithium aluminum hydride is used and a method in which a propargyl type alcohol is catalytically reduced in the presence of a hydrogenation catalyst in a solvent of a hydrocarbon such as n-hexane, n-heptane, octane, benzene, toluene or xylene, and/or an alcohol such as methanol, ethanol and propanol can be exemplified. From an industrial viewpoint, the latter method is preferred. The hydrogenation of 3,7,11-trimethyl-6-dodecene-1-yn-3-ol is carried out, e.g., in an atmosphere of hydrogen, at a hydrogen pressure of from normal pressure to 49.05 bar (50 kg/cm 2 ), and preferably from 1.962 to 19.62 bar (2 to 20 kg/cm 2 ) and at a temperature of from 0 to 130°C, and preferably from 20 to 80°C. As the hydrogenation catalyst, a metal such as nickel, cobalt, palladium, platinum, rhodium or iridium or a compound containing any of these metals can be used. These can be supported on carriers such as activated carbon, barium sulfonate and calcium carbonate. In particular, in the present invention, a Lindlar catalyst comprising palladium sulfonate and calcium carbonate is especially preferable. After the reaction is completed, 3,7,11-trimethyl-1,6-dodecadiene-3-ol can be isolated from the reaction mixture by a conventional method, e.g., by distillation. Step (e): In the step f, 6,10,14-trimethyl-5,9-pentadecadien-2-one is formed from the 3,7,11-trimethyl-1,6-dodecadien-3-ol obtained in the step (b). As a method for the step (e), either method is selected from a method in which the 3,7,11-trimethyl-1,6-dodecadien-3-ol is allowed to react with diketene or an acetoacetic acid ester to form an acetoacetic acid ester of 3,7,11-trimethyl-1,6-dodecadien-3-ol and subjecting the resultant ester to Carroll rearrangement, or a method in which the 3,7,11-trimethyl-1,6-dodecadien-3-ol is allowed to react with an isopropenyl alkyl ether to form an isopropenyl ether of 3,7,11-trimethyl-1,6-dodecadien-3-ol and subjecting the resultant ether to Claisen rearrangement. This step (e) can be carried out following the procedure described in the step (c). More specifically, in the former method, which employs Carroll rearrangement, first, the acetoacetic acid ester of 3,7,11-trimethyl-1,6-dodecadien-3-ol is formed by allowing 3,7,11-trimethyl-1,6-dodecadien-3-ol to react with diketene usually in an amount of from 0.8 to 2 moles, and preferably from 0.9 to 1.2 moles, per mole of the former. In this instance, the acetoacetic acid ester can be formed by merely making the 3,7,11-trimethyl-1,6-dodecadien-3-ol contact with diketene without a solvent or in an organic solvent which does not inhibit the reaction such as hydrocarbons or ethers. If necessary, the reaction can be conducted with heating to from 50 to 100°C. Also, an amine such as triethylamine or pyridine can be added in a catalytic amount to the reaction mixture, which accelerates the rate of esterification and improves the yield of the acetoacetic acid ester of 3,7,11-trimethyl-1,6-dodecadien-3-ol. Next, the acetoacetic acid ester of 3,7,11-trimethyl-1,6-dodecadien-3-ol thus obtained is heated to usually from 130 to 180°C, and preferably from 150 to 180°C, in order to make the Carroll rearrangement (rearrangement and successive decarboxylation reaction) proceed to give 6,10,14-trimethyl-5,9-pentadecadien-2-one. At this step, an aluminum alkoxide such as aluminum isopropoxide can be added in a catalytic amount to the reaction mixture, which improves the yield of the 6,10,14-trimethyl-5,9-pentadecadien-2-one. Also 6,10,14-trimethyl-5,9-pentadecadien-2-one can be obtained from the 3,7,11-trimethyl-1,6-dodecadien-3-ol and diketene in one pot by mixing the reactants necessary for the above two-step reaction (esterification reaction and Carroll rearrangement) all at once and controlling the reaction temperature. In the foregoing, the reaction can be operated under similar conditions when an acetoacetic acid ester such as methyl acetoacetate or ethyl acetoacetate is used in place of the diketene, and the similar results as in the foregoing can be obtained. Meanwhile, in the latter method, which employs Claisen rearrangement, the mixture of the 3,7,11-trimethyl-1,6-dodecadien-3-ol and an isopropenyl alkyl ether such as isopropeny methyl ether or isopropenyl ethyl ether in an amount of from 0.5 to 10 moles, and preferably from 0.8 to 3 moles, per mole of the former are heated at a temperature of from 50 to 200°C, and preferably from 100 to 200°C, in the presence of an acidic catalyst such as phosphoric acid, sulfuric acid, oxalic acid or trichloroacetic acid to effect isopropenyl etherification of the 3,7,11-trimethyl-1,6-dodecadien-3-ol, and the resultant ether is converted into 6,10,14-trimethyl-5,9-pentadecadien-2-one by Claisen rearrangement. After the reaction is completed, 6,10,14-trimethyl-5,9-pentadecadien-2-one can be isolated from the reaction mixture by a conventional method, e.g., by distillation. Step (f): In the step (f), the 6,10,14-trimethyl-5,9-pentadecadien-2-one obtained in the step (e) is subjected to hydrogenation to form phyton (6,10,14-trimethylpentadecan-2-one). This hydrogenation can be carried out by a known method that can convert a carbon-carbon double bond to a saturated carbon-carbon bond. For example, the 6,10,14-trimethyl-5,9-pentadecadien-2-one can be hydrogenated generally in an autoclave, in the presence of a conventional hydrogenation catalyst comprised of palladium, platinum, Raney nickel, Raney cobalt or the like (preferably palladium on carbon), without solvent or in a solvent including hydrocarbons, alcohols, ethers, ketones, esters and carboxylic acids, under hydrogen pressure of from 0.981 to 98.1 bar (1 to 100 kg/cm 2 ), and preferably from 0.981 to 19.62 bar (1 to 20 kg/cm 2 ), and at a temperature of from 15 to 150°C, and preferably from 30 to 130°C. The reaction time can be appropriately set in accordance with the kind of the solvent or the hydrogen pressure. After the reaction is completed, phyton (6,10,14-trimethylpentadecan-2-one) can be isolated from the reaction mixture by a conventional method, e.g., by distillation. Step (g): In the step (g), isophytol is formed from the phyton formed in the step (f). As a method for the step (g), either method is selected from a method in which the phyton is allowed to react with a vinyl magnesium halide to effect vinylation, or a method in which the phyton is subjected to ethynylation and successive partial hydrogenation. This step (g) can be carried out following the procedure described in the step (b). More specifically, in the former method, in which the phyton is allowed to react with a vinyl magnesium halide, isophytol (3,7,11,15-tetramethyl-1-hexadecen-3-ol) can be obtained by, e.g., adding the phyton to a vinyl magnesium halide prepared from a vinyl halide such as vinyl chloride or vinyl bromide and metal magnesium in a solvent such as tetrahydrofuran or diethyl ether, in such an amount of from 0.5 to 2 moles per mole of the vinyl magnesium halide to carry out reaction at a temperature of usually from -10 to 55°C, and preferably from 0 to 40°C, followed by hydrolysis using a dilute aqueous sulfuric acid, a saturated aqueous ammonium chloride or the like. In the latter method, in which the phyton is subjected to ethynylation and successive partial hydrogenation, the phyton is first ethynylated by a conventional method to form 3,7,11,15-tetramethyl-1-hexadecyn-3-ol, having 20 carbon atoms and having a carbon-carbon triple bond at the terminal. Here, the ethynylation can be carried out by a known process process in which ketones are ethynylated to form compounds having a propargyl alcohol structure. When the ethynylation is carried out in a small scale, it is also possible to use a method with acetylide of an alkali metal such as lithium, sodium or potassium or an alkaline earth metal such as calcium, or a method with an ethynyl magnesium halide. When the ethynylation is carried out in an industrial scale, it is suitable to use, as described below, a method of direct ethynylation by acetylene in the presence of a strong base, because 3,7,11,15-tetramethyl-1-hexadecyn-3-ol can be produced at a low production cost and the work up can be made easily. This direct ethynylation is carried out by a process in which the phyton is allowed to react with acetylene, usually in an amount of from 1 to 10 moles per mole of the former, at -30°C to 30°C for usually from 1 hour to 20 hours. The reaction is carried out under conditions where a strong base containing an alkali metal such as sodium or potassium (e.g., a hydroxide of the alkali metal, an alkali metal alcoholate or an alkali metal amide) is present in a catalytic amount, and in an organic solvent which does not inhibit the reaction such as N,N-dimethylformamide, dimethyl sulfoxide, N-methylpyrrolidone, tetrahyrofuran, dimethyl ether, diethyl ether, methyl ethyl ether, anisole or dioxane, or liquid ammonia, or a mixed solvent of these. After the reaction, the acetylene is purged off from the reaction vessel, and 3,7,11,15-tetramethyl-1-hexadecyn-3-ol is obtained as a residue. Next, the 3,7,11,15-tetramethyl-1-hexadecyn-3-ol thus obtained is partially hydrogenated to give the isophytol. This partial hydrogenation intends to selectively reduce the carbon-carbon triple bond to a carbon-carbon double bond, and methods therefor are known per se. As methods for such reduction, a method in which a hydrogenating agent such as lithium aluminum hydride is used and a method in which a propargyl type alcohol is catalytically reduced in the presence of a hydrogenation catalyst in a solvent of a hydrocarbon such as n-hexane, n-heptane, octane, benzene, toluene or xylene, and/or an alcohol such as methanol, ethanol or propanol can be exemplified. From an industrial viewpoint, the latter method is preferred. The hydrogenation of 3,7,11,15-tetramethyl-1-hexadecyn-3-ol is carried out, e.g., in an atmosphere of hydrogen, at a hydrogen pressure of from normal pressure to 49.05 bar (50 kg/cm 2 ), and preferably from 1.962 to 19.62 bar (2 to 20 kg/cm 2 ), and at a temperature of from 0 to 130°C, and preferably from 20 to 80°C. As the hydrogenation catalyst, a metal such as nickel, cobalt, palladium, platinum, rhodium or iridium or a compound containing any of these metals can be used. These can be supported on carriers such as activated carbon, barium sulfonate and calcium carbonate. In particular, in the present invention , a Lindlar catalyst comprising palladium supported on calcium carbonate is especially preferable. After the reaction is completed, isophytol can be isolated from the reaction mixture by a conventional method, e.g., by distillation. Further, the production process according to the first embodiment of the present invention that achieves the object of the present invention will be described below. The production process according to the first embodiment of the present invention is a process for producing a 6-methyl-2-heptanone analogue represented by Formula (1): wherein n is an integer of 0 or 1 to 4; the process comprising the step of allowing hydrogen, acetone and an aldehyde represented by Formula (2): wherein n is as defined above; X and Y each represents hydrogen atom or they are coupled together to form a carbon-carbon bond; and Z and W each represents a hydrogen atom or they are coupled together to form a carbon-carbon bond; to react in the presence of an aqueous alkali solution containing an alkaline substance, and a hydrogenation catalyst. In this process, in order to improve the yield of the 6-methyl-2-heptanone analogue of Formula (1), it is preferable to make the aldehyde of Formula (2) and the aqueous alkali contact with hydrogen while each continuously adding the aldehyde compound and the aqueous alkali to a suspension of the hydrogenation catalyst in the acetone. In the above process of the present invention, there are no particular limitations on the ratio of the acetone to the aldehyde of Formula (2). However, in order to improve the selectivity to the 6-methyl-2-heptanone analogue of Formula (1) on the basis of the aldehyde of Formula (2), which is more expensive, acetone is preferably used within the range of from 0.5 mole to 10 moles per mole of the aldehyde of Formula (2). From the viewpoint of improving the volumetric efficiency of the reaction to reduce the amount of unreacted acetone which should be recovered, the acetone is more preferably used within the range of from 0.8 mole to 5 moles, and particularly preferably from 0.9 mole to 3 moles, per mole of the aldehyde of Formula (2). The alkaline substance used in the above process the present invention includes, e.g., alkali metal hydroxides such as sodium hydroxide and potassium hydroxide, alkaline-earth metal hydroxides such as barium hydroxide and calcium hydroxide, alkali metal carbonates such as potassium carbonate, and amine compounds such as piperidine. In particular, alkali metal hydroxides and alkaline-earth metal hydroxides are preferred as the alkaline substance. The alkaline substance can be used alone or in combination of two or more types. The alkaline substance can be used in an amount of usually from 0.001 to 0.2 mole per mole of the aldehyde of Formula (2), and, from the viewpoint of reaction rate and production cost of the 6-methyl-2-heptanone analogue of Formula (1), preferably from 0.01 to 0.1 mole per mole of the aldehyde of Formula (2). The alkaline substance can be used in the aqueous alkali in a concentration of usually from 0.5 to 30% by weight, and preferably from 1 to 10% by weight. As the hydrogenation catalyst in the above process of the present invention, catalysts conventionally used when carbon-carbon double bonds of unsaturated carbonyl compounds are selectively hydrogenated can be employed, including, e.g., catalysts comprising palladium, rhodium, nickel, platinum or the like as an active component. The hydrogenation catalyst includes a metal itself, a metal oxide, an alloy of the several kinds of metals, and ones with an active component supported on carriers such as activated carbon, alumina, silica gel and kieselguhr. Among them, palladium on carbon, palladium on alumina, Raney nickel and platinum on carbon are preferred. Further, palladium on carbon and palladium on alumina are more preferred. The hydrogenation catalyst is usually used in an amount of from 0.01 to 10% by weight based on the weight of the aldehyde of Formula (2). From the viewpoints of reaction rate and the production cost of the 6-methyl-2-heptanone analogue of Formula (1), the hydrogenation catalyst is preferably used in an amount of from 0.03 to 3% by weight based on the weight of the aldehyde of Formula (2). In the above process of the present invention, it is not always necessary to use a solvent. However, so long as the progress of reaction is not inhibited, an appropriate solvent can be used. Usable solvents include, e.g., aliphatic alcohols such as methanol, ethanol, propanol, isopropanol, n-butanol, s-butanol and t-butanol; ethers such as tetrahydrofuran, 1,4-dioxane, diethyl ether, diisopropyl ether and di-n-butyl ether; and hydrocarbons such as hexane, heptane, octane, benzene, toluene and xylene. As a specific operation for the production process of the present invention, the aldehyde of Formula (2), acetone, an aqueous alkali and a hydrogenation catalyst are mixed together at a temperature within a pre-determined range and in an atmosphere of hydrogen, in a usual manner of operation, without requiring any special equipment. In such operation, there are no particular limitations on the order or the rate of the addition of the respective components. All the components, i.e., acetone, an aldehyde of Formula (2), an aqueous alkali and a hydrogenation catalyst can be mixed at one time. In addition one or two of acetone, an aldehyde of Formula (2) and an aqueous alkali can be introduced into a reaction vessel together with the hydrogenation catalyst and the remaining components is continuously added to the reaction vessel. Here, the term "continuously add" embraces an embodiment that the said remaining components are added in parts by several times. In particular, as a method of mixing the respective components, in order to prevent the runaway of the reaction and to produce the 6-methyl-2-heptanone analogue of Formula (1) in a high yield and selectivity, a method is preferred in which an aqueous alkali and an aldehyde of Formula (2) are each continuously added to a suspension of a hydrogenation catalyst in acetone. In this case, acetone can be present in great excess to the aldehyde of Formula (2) in the reaction mixture during the greater period of the reaction, so that side reactions due to, e.g., self condensation of the aldehyde of Formula (2) are supressed and the corresponding 6-methyl-2-heptanone analogue of Formula (1) can be obtained in a high yield and selectivity. The reaction is usually carried out at a temperature ranging from 20 to 180°C, and preferably from 40 to 140°C, in order to control the reaction rate at a practical level and also to improve the selectivity to the 6-methyl-2-heptanone analogue of Formula (1). The time for the reaction depends on the kind and concentration of the alkaline substance and on the reaction temperature. In the case when, as previously stated, the aqueous alkali and the aldehyde of Formula (2) are each continuously added to the suspension of the hydrogenation catalyst in acetone, the aldehyde of Formula (2) and the aqueous alkali may be added for 30 minutes to 10 hours. After their addition is completed, the reaction can further be run to the completion for 0 to 10 hours. In the course the aldehyde of Formula (2) and the aqueous alkali are added and in the course the reaction is run to the completion, the reaction mixture is preferably stirred thoroughly. In the above process of the present invention, the hydrogen is made to contact with the surface of a mixture of acetone, an aldehyde of Formula (2), an aqueous alkali and a hydrogenation catalyst. Also hydrogen can be introduced (bubbled) into the mixture. The pressure of hydrogen is usually within the range of from 1.013 to 10.13 bar (1 to 100 atmospheric pressure). A pressure within the range of from 1.013 to 10.13 bar (1 to 10 atmospheric pressure) is preferable because a usual reaction vessel can be used. After the reaction is completed, the 6-methyl-2-heptanone analogue of Formula (1) can be isolated by a usual method, e.g., a method in which the hydrogenation catalyst is removed from the reaction mixture by filtration, centrifugal separation or the like method, followed by separation of the aqueous layer, and the resulting organic layer is distilled, or a method in which the hydrogenation catalyst is removed from the reaction mixture, followed by extraction with an organic solvent, and the resulting organic layer is concentrated under normal pressure or reduced pressure. The organic solvent used in the above extraction includes, e.g., hydrocarbons such as toluene, benzene, hexane and cyclohexane, and halogenated hydrocarbons such as methylene chloride, chloroform, carbon tetrachloride and dichloroethane. As described above, according to the process of the present invention, industrially readily available materials (the aldehyde of Formula (2), e.g., isovaleraldehyde, and acetone) are contact with hydrogen in the presence of an aqueous alkali and a hydrogenation catalyst, to give the corresponding 6-methyl-2-heptanone analogue of Formula (1) in one pot, in a high yield and selectivity on the basis of the aldehyde compound of Formula (2). In the aldehyde of Formula (2), n is an integer of 0 or 1 to 4. In particular, aldehydes wherein n is 0, 1 or 2 are preferred. In such a case, the integer n in the 6-methyl-2-heptanone analogue of Formula (1) is 0, 1 or 2 corresponding to the integer n of the aldehyde of Formula (2). Here, as examples of the aldehyde of Formula (2) wherein n is 0, they include senecioaldehyde (Z and W are coupled together to form a carbon-carbon bond) and isovaleraldehyde (Z and W represent both hydrogen atoms). In this case, as the compound of Formula (1), 6-methyl-2-heptanone (n is 0) is obtained. As examples of the aldehyde of Formula (2) wherein n is 1, they include citral (X and Y are coupled together to form a carbon-carbon bond and Z and W are coupled together to form a carbon-carbon bond), citronellal (X and Y are coupled together to form a carbon-carbon bond and Z and W are both hydrogen atoms) and tetrahydrocitral (X and Y, and Z and W are all hydrogen atoms). In this case, as the compound of Formula (1), 6,10-dimethyl-2-undecanone (n is 1) is obtained. As examples of the aldehyde of Formula (2) wherein n is 2, they include farnesal (X and Y are coupled together to form a carbon-carbon bond and Z and W are coupled together to form a carbon-carbon bond) and hexahydrofarnesal (X and Y, and Z and W are all hydrogen atoms). In this case, as the compound of Formula (1), phyton (n is 2) is obtained. As examples of the aldehyde of Formula (2) wherein n is 3, they include 3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenal (X and Y are coupled together to form a carbon-carbon bond and Z and W are coupled together to form a carbon-carbon bond), 3,7,11,15-tetramethyl-6,10,14-hexadecatrienal (X and Y are coupled together to form a carbon-carbon bond and Z and W are both hydrogen atoms) and 3,7,11,15-tetramethylhexadecanal (X and Y, and Z and W are all hydrogen atoms). In this case, as the compound of Formula (1), 6,10,14,18-tetramethyl-2-nonadecanone (n is 3) is obtained. As examples of the aldehyde of Formula (2) wherein n is 4, they include 3,7,11,15,19-pentamethyl-2,6,10,14,18-eicosapentaenal (X and Y are coupled together to form a carbon-carbon bond and Z and W are coupled together to form a carbon-carbon bond), 3,7,11,15,19-pentamethyl-6,10,14,18-eicosatetraenal (X and Y are coupled together to form a carbon-carbon bond and Z and W are both hydrogen atoms) and 3,7,11,15,18-pentamethyleicosanal (n is 4, X and Y, and Z and W are all hydrogen atoms). In this case, as the compound of Formula (1), 6,10,14,18,22-pentamethyl-2-tricosanone (n is 4) is obtained. In the above process of the present invention, the aldehyde of Formula (2) can be used alone, or can be used in the form of a mixture of two or more types having the same number of carbon atoms. Phyton or isophytol can be produced using, as a material, the 6-methyl-2-heptanone analogue of Formula (1) thus obtained (n is 0, 1 or 2). For example, from the 6-methyl-2-heptanone, i.e., the compound of Formula (1) wherein n is 0, phyton can be obtained by subjecting the 6-methyl-2-heptanone to the steps (b) to (f) as described above, and isophytol can be obtained by further subjecting the above phyton to the step (g) described above. From the phyton, i.e., the compound of Formula (1) wherein n is 2, isophytol can be obtained by subjecting the phyton to the step (g) as described above. Further, from the 6,10-dimethyl-2-undecanone, i.e., the compound of Formula (1) wherein n is 1, phyton can be obtained by subjecting the 6,10-dimethylundecan-2-one to steps (d') to (f') described below, and isophytol can be obtained by further subjecting the above phyton to the step (g) as described above. Step (d'): A step where 3,7,11-trimethyl-1-dodecen-3-ol is formed from the 6,10-dimethyl-2-undecanone by adding a vinyl group to the carbonyl group at its terminal. As a method for the step (d'), either method is selected from a method in which the 6,10-dimethyl-2-undecanone is allowed to react with a vinyl magnesium halide to effect vinylation, or a method in which the 6,10-dimethyl-2-undecanone is subjected to ethynylation and successive partial hydrogenation. For the industrial application, it is more advantageous to effect the latter ethynylation and successive partial hydrogenation. In the former method, in which the 6,10-dimethyl-2-undecanone is allowed to react with a vinyl magnesium halide reagent, the 3,7,11-trimethyl-1-dodecen-3-ol can be obtained by, e.g., adding the 6,10-dimethyl-2-undecanone to a vinyl magnesium halide prepared from a vinyl halide such as vinyl chloride or vinyl bromide and metal magnesium in a solvent such as tetrahydrofuran or diethyl ether, in such an amount of from 0.5 to 2 moles per mole of the vinyl magnesium halide to carry out reaction at a temperature of usually from -10 to 55°C, and preferably from 0 to 40°C, followed by hydrolysis using a dilute aqueous sulfuric acid, a saturated aqueous ammonium chloride or the like. In the latter method, in which the 6,10-dimethyl-2-undecanone is subjected to ethynylation and successive partial hydrogenation, the 6,10-dimethyl-2-undecanone is first ethynylated by a conventional method to form 3,7,11-trimethyldodecan-1-yn-3-ol, having 15 carbon atoms and having a carbon-carbon triple bond at the terminal. Here, the ethynylation can be carried out by a known process as a process in which ketones are ethynylated to form compounds having a propargyl alcohol structure. When the ethynylation is carried out in a small scale, it is also possible to use a method with an acetylide of an alkali metal such as lithium, sodium or potassium or an alkaline earth metal such as calcium or a method with an ethynyl magnesium halide. When the ethynylation is carried out in an industrial scale, it is suitable to use, as described below, a method of direct ethynylation by acetylene in the presence of a strong base catalyst, because 3,7,11-trimethyldodecan-1-yn-3-ol can be produced at a low production cost and the work up can be made easily. This direct ethynylation is carried out by a process in which the 6,10-dimethyl-2-undecanone is allowed to react with acetylene, usually in an amount of from 1 to 10 moles per mole of the former, at -30°C to 30°C for 1 hour to 20 hours. The reaction is carried out under conditions where a strong base compound containing an alkali metal such as sodium or potassium (e.g., a hydroxide of the alkali metal, an alkali metal alcoholate or an alkali metal amide) is present in a catalytic amount, and in an organic solvent which does not inhibit the reaction such as N,N-dimethylformamide, dimethyl sulfoxide, N-methylpyrrolidone, tetrahyrofuran, dimethyl ether, diethyl ether, methyl ethyl ether, anisole or dioxane, or liquid ammonia, or a mixed solvent of these. After the reaction, the acetylene is purged off from the reaction vessel, and 3,7,11-trimethyldodecan-1-yn-3-ol is obtained as a residue. Next, the 3,7,11-trimethyldodecan-1-yn-3-ol obtained as described above is partially hydrogenated to give the 3,7,11-trimethyl-1-dodecen-3-ol. This partial hydrogenation intends to selectively reduce the carbon-carbon triple bond to a carbon-carbon double bond, and methods therefor are known per se. As methods for such reduction, a method in which a hydrogenating agent such as lithium aluminum hydride is used and a method in which a propargyl type alcohol is catalytically reduced in the presence of a hydrogenation catalyst in a solvent of a hydrocarbon such as n-hexane, n-heptane, octane, benzene, toluene or xylene, and/or an alcohol such as methanol, ethanol and propanol can be exemplified. From an industrial viewpoint, the latter method is preferred. The hydrogenation of 3,7,11-trimethyldodecan-1-yn-3-ol is carried out, e.g., in an atmosphere of hydrogen, at a hydrogen pressure of from normal pressure to 49.05 bar (50 kg/cm 2 ), and preferably from 1.962 to 19.62 bar (2 to 20 kg/cm 2 ), and at a temperature of from 0 to 130°C, and preferably from 20 to 80°C. As the hydrogenation catalyst, a metal such as nickel, cobalt, palladium, platinum, rhodium or iridium or a compound containing any of these metals can be used. These can be supported on carriers such as activated carbon, barium sulfonate and calcium carbonate. In particular, in the present invention, a Lindlar catalyst comprising palladium supported on calcium carbonate is especially preferable. After the reaction is completed, 3,7,11-trimethyl-1-dodecan-3-ol can be isolated from the reaction mixture by a conventional method, e.g., by distillation. Step (e'): A step where 6,10,14-trimethyl-5-pentadecen-2-one is formed from the 3,7,11-trimethyl-1-dodecen-3-ol obtained in the step (d'). As a method for the step (e'), either method is selected from a method in which the 3,7,11-trimethyl-1-dodecen-3-ol is allowed to react with diketene or an acetoacetic acid ester to form an acetoacetic acid ester of 3,7,11-trimethyl-1-dodecen-3-ol and subjecting the resultant ester to Carroll rearrangement, or a method in which the 3,7,11-trimethyl-1-dodecen-3-ol is allowed to react with an isopropenyl alkyl ether to form an isopropenyl ether of 3,7,11-trimethyl-1-dodecen-3-ol and subjecting the resultant ether to Claisen rearrangement. In the former method, which employs Carroll rearrangement, first, the acetoacetic acid ester of 3,7,11-trimethyl-1-dodecen-3-ol is formed by allowing 3,7,11-trimethyl-1-dodecen-3-ol to react with diketene usually in an amount of from 0.8 to 2 moles, and preferably from 0.9 to 1.2 moles, per mole of the former. In this instance, the acetoacetic acid ester can be formed by merely making the 3,7,11-trimethyl-1-dodecen-3-ol contact with the diketene without a solvent or in an organic solvent which does not inhibit to the reaction such as hydrocarbons or ethers. If necessary, the reaction can be conducted with heating to from 50 to 100°C. Also, an amine such as triethylamine or pyridine can be added in a catalytic amount to the reaction mixture, which accelerates the rate of esterification and improves in the yield of the acetoacetic acid ester of 3,7,11-trimethyl-1-dodecen-3-ol. Next, the acetoacetic acid ester of 3,7,11-trimethyl-1-dodecen-3-ol thus obtained is heated to usually from 130 to 180°C, and preferably from 150 to 180°C, in order to make the Carroll rearrangement (rearrangement and successive decarboxylation) proceed to give 6,10,14-trimethyl-5-pentadecen-2-one. At this step, an aluminum alkoxide such as aluminum isopropoxide can be added in a catalytic amount to the reaction mixture, which improves the yield of the 6,10,14-trimethyl-5-pentadecen-2-one. Also, the 6,10,14-trimethyl-5-pentadecen-2-one can be obtained from the 3,7,11-trimethyl-1-dodecen-3-ol and diketene in one pot by mixing the reactants necessary for the above two-step reaction (esterification and Carroll rearrangement) all at once and controlling the reaction temperature. In the foregoing, the reaction can be operated under similar conditions when an acetoacetic acid ester such as methyl acetoacetate or ethyl acetoacetate is used in place of diketene, and the similar results as in the foregoing can be obtained. These reactions and their mechanisms are described in the literature [see e.g., J. Chem. Soc. 704 (1940); Japanese Patent Publications No. sho32-8616 and No. sho49-25251; British Patent No. 907,142 etc.]. Meanwhile, in the latter method, which employs Claisen rearrangement, the mixture of 3,7,11-trimethyl-1-dodecen-3-ol and an isopropenyl ether such as isopropenyl methyl ether of isopropenyl ethyl ether in an amount of from 0.5 to 10 moles, and preferably from 0.8 to 3 moles, per mole of the former are heated at a temperature of from 50 to 200°C, and preferably from 100 to 200°C, in the presence of an acidic catalyst such as phosphoric acid, sulfuric acid, oxalic acid or trichloroacetic acid to effect isopropenyl etherification of the 3,7,11-trimethyl-1-dodecen-3-ol, and the resultant ether is converted into 6,10,14-trimethyl-5-pentadecen-2-one by Claisen rearrangement. After the reaction is completed, 6,10,14-trimethyl-5-pentadecen-2-one can be isolated from the reaction mixture by a conventional method, e.g., by distillation. Step (f'): The 6,10,14-trimethyl-5-pentadecen-2-one obtained in the step (e') is subjected to hydrogenation to form phyton (6,10,14-trimethylpentadecan-2-one) . This hydrogenation can be carried out by a known method that can convert a carbon-carbon double bond to a saturated carbon-carbon bond. For example, the 6,10,14-trimethyl-5-pentadecen-2-one can be hydrogenated generally in an autoclave, in the presence of a conventional hydrogenation catalyst comprised of palladium, platinum, Raney nickel, Raney cobalt or the like (preferably palladium on carbon), without solvent or in a solvent including hydrocarbons, alcohols, ethers, ketones, esters and carboxylic acids, under hydrogen pressure of from 0.981 to 98.1 bar (1 to 100 kg/cm 2 ), and preferably from 0.981 to 19.62 bar (1 to 20 kg/cm 2 ), and at a temperature of from 15 to 150°C, and preferably from 30 to 130°C. The reaction time can be appropriately set in accordance with the kind of the solvent or and the hydrogen pressure. After the reaction is completed, phyton (6,10,14-trimethylpentadecan-2-one) can be isolated from the reaction mixture by a conventional method, e.g., by distillation. EXAMPLES The present invention will be described below in detail. The present invention is by no means limited to these Examples. Reference Example 1 An autoclave made of stainless steel, equipped with a stirrer and a jacket and having an internal volume of 10 liters, was charged with 1,403.1 g (24.2 moles) of acetone in an atmosphere of nitrogen, and then heated with stirring at the jacket temperature of 72°C. At the time the temperature and pressure inside the autoclave reached 68°C and 1.8639 bar (1.9 kg/cm 2 ) (gauge pressure), respectively, aqueous 2% sodium hydroxide and isovaleraldehyde were each continuously fed, the former at a rate of 774 g/h and the latter at 679 g/h. After they were began to be fed, the temperature inside the autoclave gradually became higher. The feed of aqueous 2% sodium hydroxide and isovaleraldehyde were continued for 175 minutes while keeping the temperature inside the autoclave at 70 to 72°C with stirring. The amount of aqueous 2% sodium hydroxide fed during this time was 2,253.7 g (1.12 moles in terms of NaOH), and the amount of isovaleraldehyde fed was 1,979.4 g (22.99 moles) . After the feed of the aqueous 2% sodium hydroxide and isovaleraldehyde was completed, the reaction mixture was kept at temperatures within the above range and stirred for 1.5 hours to run the reaction to the completion. After cooling to room temperature, the reaction mixture was taken out and left to stand, then separated into two layers. The organic layer (upper layer) was collected, and analyzed by gas chromatography (column: DC QF1, available from Gaskuro Kogyou Inc.; Column length: 1m; Column temperature: raised from 60°C to 200°C; Rising Rate of temperature: 5°C/min.) to find that 1,909.0 g (yield: 66%) of 6-methyl-3-hepten-2-one and 107.3 g (yield: 3.3%) of 6-methyl-4-hydroxyheptan-2-one were contained in 2,938.8 g of the organic layer. The conversion of isovaleraldehyde was 98.3%. 2,938.8 g of the organic layer thus obtained was distilled under reduced pressure to give 1,824.3 g (purity: 98%) of 6-methyl-3-hepten-2-one (b.p.: 113-115°C/0.133 bar (113-115°C/100 mmHg)). Reference Example 2 An autoclave made of stainless steel, equipped with a stirrer and a jacket and having an internal volume of 10 liters, was charged with 1,470 g (25.3 moles) of acetone and 217 g (2.52 moles) of isocaleraldehyde in an atmosphere of nitrogen, and the resultant mixture was heated with stirring at the jacket temperature of 60°C. At the time the temperature and pressure inside the autoclave reached 57.7°C and 0.981 bar (1.0 kg/cm 2 ) (gauge pressure), respectively, aqueous 2% sodium hydroxide and isovaleraldehyde were each continuously fed into the above mixture, the former at a rate of 774 g/h and the latter at 605 g/h. About 3 minutes after the feed of them had been started, the temperature inside the autoclave began to rise, and, 5 minutes thereafter, it reached a maximum temperature of 70.6°C. About 4 minutes after the temperature inside the autoclave began to rise, the pressure inside the autoclave reached a maximum pressure of 1.7658 bar (1.8 kg/cm 2 ). 10 minutes after the feed of the aqueous 2% sodium hydroxide and isovaleraldehyde had been started, the jacket temperature was set at 70 to 72°C and the reaction was continued while keeping the temperature inside the autoclave at 63.4 to 71.2°C. The feed of the aqueous 2% sodium hydroxide and isovaleraldehyde was continued for 175 minutes until 2,256.2 g (1.128 moles in terms of Sodium hydroxide) of the aqueous 2% sodium hydroxide and 1,764.1 g (20.51 moles) of the isovaleraldehyde were added in the acetone. After the feed of the aqueous 2% sodium hydroxide and isovaleraldehyde was completed, the resultant reaction mixture was stirred for 1.5 hours at the same temperatures to run the reaction to the completion. After cooling to room temperature, the reaction mixture was taken out and left to stand, then separated into two layers. The organic layer (upper layer) was collected, and analyzed by gas chromatography to find that 1,926.1 g (yield: 66.5%) of 6-methyl-3-hepten-2-one and 107.4 g (yield: 3.3%) of 6-methyl-4-hydroxyheptan-2-one were contained in 2,993.8 g of the organic layer. The conversion of isovaleraldehyde was 98.2%. Comparative Example 1 An example is shown below in which the reaction vessel equipped with a stirrer and a reflux condenser was charged with acetone, isovaleraldehyde and aqueous 2% sodium hydroxide at the same time. More specifically, the inside of a reaction vessel having an internal volume of 300 ml was thoroughly replaced with nitrogen, and then 30.5 g (525 mmols) of acetone, 43.1 g (500 mmols) of isovaleraldehyde and 50.0 g (50 mmols in terms of NaOH) of aqueous 2% sodium hydroxide were added at the same time into the reaction vessel, followed by stirring at the temperature inside the reaction vessel of of 45°C. The heat generated with the reaction raised the temperature inside the reaction vessel up to 55°C. The resultant reaction mixture was stirred at the temperatures inside the reaction vessel of 55 to 65°C. After cooling to room temperature, the reaction mixture was taken out and made to separate into two layers. The organic layer (upper layer) was collected and analyzed by gas chromatography to find that 35.7 g (yield: 56.6%) of 6-methyl-3-hepten-2-one was contained in 64.3 g of the organic layer. As is seen from this result, when the acetone, isovaleraldehyde and aqueous 2% sodium hydroxide are added at the same time into the reaction vessel, the yield of the 6-methyl-3-hepten-2-one is reduced. Reference Example 3 (Step (a)) The procedure of Reference Example 1 was repeated using 1,470.0 g (25.3 moles) of acetone, 1,981.9 g (23.0 moles) of isovaleraldehyde and 2,256.2 (1.128 moles in terms of NaOH) of aqueous 2% sodium hydroxide, to give 2,993.8 g of an organic layer containing 1,926.1 g (yield: 66.5%) of 6-methyl-3-hepten-2-one. (Step (b)) An autoclave having an internal volume of 5 liters was charged with 2,823.3 g of the organic layer containing 1,816.4 g (14.4 moles) of 6-methyl-3-hepten-2-one, obtained by the above step (a), and 1.93 g of a 5% palladium on carbon catalyst to carry out the hydrogenation for 7 hours under hydrogen pressure of 4.905 to 8.829 bar (5 to 9 kg/cm 2 ) at a reaction temperature of 120°C. Thereafter, the catalyst was filtered off, and the resultant filtrate was analyzed by gas chromatography (capillary column: CBP-10, available from Gasukuro Kogyo Inc.; column length: 50 m; column temperature: raised from 70 to 240°C; rising rate of temperature: 5°C/min.) to find that 1,890.4 g (yield: 100%) of 6-methyl-2-heptanone was contained in the filtrate. Next, the acetone was removed from this filtrate under normal pressure, then components having boiling points of 33 to 132°C were removed under a pressure of 300 mmHg. The residue was purified with distillation to give 1,628.9 g of 6-methyl-2-heptanone (boiling point: 103°C/0.173 bar (103°C/100 mmHg); purity: 99% or higher). (Step (c)) An autoclave having an internal volume of 3 liters was charged with 31.0 g (221.4 mmols in terms of KOH) of aqueous 40% potassium hydroxide, 1.1 kg (64.7 moles) of liquid ammonia and 0.18 kg (6.92 moles) of acetylene. Thereafter, keeping the temperature inside the autoclave at 4 to 6°C, 435.9 g (3.366 moles) of the 6-methyl-2-heptanone obtained in the step (b) was introduced into the autoclave to initiate the ethynylation. The ethynylation was carried out at 4 to 6°C for 2 hours, and then 69.8 g of aqueous 25% ammonium sulfate was introduced into the autoclave to stop the reaction. Thereafter, ammonia was purged off from the autoclave while gradually raising the temperature inside the autoclave to room temperature. Next, 220 g of hexane and 440 g of water were added to the autoclave. A hexane solution containing 3,7-dimethyl-1-octyn-3-ol was obtained by collecting the organic layer, followed by washing with water. Above the procedures for the ethynylation of 6-methyl-2-heptanone were repeated twice (three times in total) to obtain, in total, 2,280 g of a hexane solution containing 3,7-dimethyl-1-octyn-3-ol (hexane content: 680 g). The conversions of 6-methyl-2-heptanone were, as a result of analysis by gas chromatography (column: PEG-20M, available from Gasukuro Kogyo Inc.; column length: 3 m; column temperature: 140°C), 94.7%, 98.0% and 97.2% for the respective runs of the ethynylation. An autoclave having an internal volume of 3 liters was charged with 1,140 g of the hexane solution containing 3,7-dimethyl-1-octyn-3-ol thus obtained and 0.27 g of a Lindlar catalyst (supported on calcium carbonate) to carry out the hydrogenation for 4 hours under hydrogen pressure of 4.905 to 7.848 bar (5 to 8 kg/cm 2 ) (gauge pressure) at a temperature of 25 to 43°C. Thereafter, the catalyst was filtered off, and the resultant filtrate was concentrated with a rotary evaporator to give crude 3,7-dimethyl-1-octen-3-ol. Above the procedures for the hydrogenation of 3,7-dimethyl-1-octyn-3-ol were repeated once more to obtain, in total, 1,590 g of crude 3,7-dimethyl-1-octen-3-ol. Analysis by gas chromatography (column: DC-550, available from Gasukuro Kogyo Inc.; column length: 3 m; column temperature: 100°C; and column: PEG-HT, available from Gasukuro Kogyo Inc.; column length: 3 m; column temperature: 130°C) revealed that the conversions of 3,7-dimethyl-1-octyn-3-ol were 99.7% and 97.3% for the respective runsof the hydrogenation, and the selectivities to 3,7-dimethyl-1-octen-3-ol were 95.0% and 95.8%, respectively. To 1,590 g of the crude 3,7-dimethyl-1-octen-3-ol thus obtained, 0.41 g of a methanolic sodium methoxide (concentration: 28%) was added, then the resulting mixture was heated at 150°C for 1 hour to decompose unreacted 3,7-dimethyl-1-octyn-3-ol. Thereafter, the resultant solution was simple distilled under a pressure of about 0.067 bar (50 mmHg) to collect 1,440 g of a fraction having a boiling point of about 115°C. This fraction was purified by removing low-boiling components (boiling point: about 80°C/about 0.027 bar (20 mmHg)) while heating under reduced pressure, to give 1,360 g of a residue. Analysis by gas chromatography (column: DC-550, available from Gasukuro Kogyo Inc.; column length: 3 m; column temperature: raised from 120 to 190°C; rising rate of temperature rise: 5°C/min.) revealed that this residue contained 93.1% of 3,7-dimethyl-1-octen-3-ol (yield on the basis of 6-methyl-2-heptanone: 80.2%). (Step (d)) A three-necked flask made of glass, equipped with a reflux condenser and having an internal volume of 2 liters was charged with 680 g (4.05 moles) of the 3,7-dimethyl-1-octen-3-ol obtained in the step (c), 2.23 g (22 mmols) of triethylamine and 5.21 g (26 mmols) of aluminum isopropoxide. To the resulting mixture, 328 g (3.905 moles) of diketene was added dropwise over a period of 1.5 hours while heating at 70 to 80°C, and the reaction was carried out for further 1 hour. Thereafter, the temperature of the reaction mixture was raised to 170°C to carry out the reaction for further 3 hours. The above procedures for the hydrogenation of 3,7-dimethyl-1-octen-3-ol with diketene were repeated once more to obtain, in total, 1,650 g of a reaction mixture (crude 6,10-dimethyl-5-undecen-2-one). Analysis by gas chromatography (column: DC-550, available from Gasukuro Kogyo Inc.; column length: 3 m; column temperature: raised from 120 to 190°C; rising rate of temperature: 5°C /min.) revealed that the conversions of 3,7-dimethyl-1-octen-3-ol were 93.1% and 92.7% for the respective runs of the reaction. Under a pressure of 9.3 x 10 -3 bar (7 mmHg), 1650 g of the reaction mixture (crude 6,10-dimethyl-5-undecen-2-one) thus obtained was simple distilled to collect 1,350 g of a fraction having a boiling point of 85 to 110°C. The fraction obtained was purified by distillation to give 1,100 g of 6,10-dimethyl-5-undecen-2-one (boiling point: about 120°C/8.0 x 10 -3 bar (6 mmHg), purity: 99.4% (yield: 69.2%)). (Step (e)) An autoclave having an internal volume of 3 liters was charged with 23.6 g (169 mmols in terms of KOH) of aqueous 40% potassium hydroxide, 1.0 kg (58.8 moles) of liquid ammonia and 0.18 kg (6.92 moles) of acetylene. Thereafter, keeping the temperature inside the autoclave at 4 to 6°C, 550.0 g (2.784 moles) of the 6,10-dimethyl-5-undecen-2-one obtained in the step (d) was introduced into the autoclave to initiate the ethynylation. The ethynylation was carried out at 4 to 6°C for 1.75 hours, and then 53.3 g of aqueous 25% ammonium sulfate was introduced into the autoclave to stop the reaction. Thereafter, ammonia was purged off from the autoclave while gradually raising the temperature inside the autoclave to room temperature. Next, 280 g of hexane and 550 g of water were added to the autoclave. A hexane solution containing 3,7,11-trimethyl-6-dodecen-1-yn-3-ol was obtained by collecting the organic layer, followed by washing with water. From this hexane solution, the hexane was removed with a rotary evaporator to give 630 g of crude 3,7,11-trimethyl-6-dodecen-1-yn-3-ol. Analysis by gas chromatography (column: PEG-20M, available from Gasukuro Kogyo Inc.; column length: 3 m; column temperature: 190°C) revealed that the conversion of 6,10-dimethyl-5-undecen-2-one was 98.0%. An autoclave having an internal volume of 3 liters was charged with 630 g of the 3,7,11-trimethyl-6-dodecen-1-yn-3-ol thus obtained, 270 g of hexane and 0.22 g of a Lindlar catalyst (supported on calcium carbonate) to carry out the hydrogenation for 4 hours under hydrogen pressure of 4.905 to 7.848 bar (5 to 8 kg/cm 2 ) (gauge pressure) at a temperature of 25 to 43°C. Thereafter, the catalyst was filtered off, and the resultant filtrate was concentrated with a rotary evaporator to give 630 g of crude 3,7,11-trimethyl-1,6-dodecadien-3-ol. Analysis by gas chromatography (column: DC-550, available from Gasukuro Kogyo Inc.; column length: 3 m; column temperature: 160°C; and column: PEG-20M, available from Gasukuro Kogyo Inc.; column length: 3 m; column temperature: 190°C) revealed that the conversion of 3,7,11-trimethyl-6-dodecen-1-yn-3-ol was 95.5%, and the selectivity to 3,7,11-trimethyl-1,6-dodecadien-3-ol was 94.6%. To 630 g of the crude 3,7,11-trimethyl-1,6-dodecadien-3-ol thus obtained, 0.16 g of a methanolic sodium methoxide (concentration: 28%) was added, then the resulting mixture was heated at 150°C for 1 hour to decompose unreacted 3,7,11-trimethyl-6-dodecen-1-yn-3-ol. Thereafter, the resultant solution was simple distilled under a pressure of 9.3 x 10 -3 to 0.016 bar (7 to 12 mmHg) to collect 520 g of a fraction having a boiling point of 120 to 135°C. Analysis by gas chromatography (column: DC-550, available from Gasukuro Kogyo Inc.; column length: 3 m; column temperature: 160°C) revealed that this fraction contained 93.7% of 3,7,11-trimethyl-1,6-dodecadien-3-ol (yield on the basis of 6,10-dimethyl-5-undecen-2-one: 78.0%). (Step (f)) A three-necked flask made of glass, equipped with a reflux condenser and having an internal volume of 2 liters, was charged with 520 g (2.17 moles) of the 3,7,11-trimethyl-1,6-dodecadien-3-ol obtained in the step (e), 1.56 g (15 mmols) of triethylamine and 3.95 g (19 mmols) of aluminum isopropoxide. The resulting mixture was heated to 70 to 80°C, then 189.7 g (2.258 moles) of diketene was added dropwise to the mixture over a period of 1.1 hours, and the reaction was carried out for further 1 hour. Thereafter, the temperature of the reaction mixture was raised to 170°C to carry out the reaction for further 3 hours. Thus, 590 g of a reaction mixture (crude 6,10,14-trimethyl-5,9-pentadecadien-2-one) was obtained. Analysis by gas chromatography (column: DC-550, available from Gasukuro Kogyo Inc.; column length: 3 m; column temperature: 210°C.) revealed that the conversion of 3,7,11-trimethyl-1,6-dodecadien-3-ol was 89.1%. Under a pressure of 4 x 10 -4 bar (0.3 mmHg), 590 g of the reaction mixture (crude 6,10,14-trimethyl-5,9-pentadecadien-2-one) thus obtained was simple distilled to collect 440 g of a fraction having a boiling point of about 110°C. The fraction obtained was purified by distillation to give 360 g of 6,10,14-trimethyl-5,9-pentadecadien-2-one (boiling point: 113°C/4 x 10 -4 bar (0.1 mmHg), purity: 99.2% (yield: 62.7%)). (Step (g)) An autoclave having an internal volume of 300 ml was charged with 120 g (453.8 mmols) of the 6,10,14-trimethyl-5,9-pentadecadien-2-one obtained in the step (f) and 0.1 g of 10% palladium on carbon to carry out the hydrogenation for 4 hours under hydrogen pressure of 19.62 bar (20 kg/cm 2 ) (gauge pressure) at a temperature of 180°C. Thereafter, the catalyst was filtered off to obtain a filtrate. The above procedures for the hydrogenation of 6,10,14-trimethyl-5,9-pentadecadien-2-one were repeated twice (three times in total) to obtain, in total, 340 g of a filtrate. Analysis by gas chromatography (column: DC-550, available from Gasukuro Kogyo Inc.; column length: 3 m; column temperature: 220°C) revealed that this filtrate was phyton (6,10,14-trimethylpentadecan-2-one) with a purity of 98.4%. Reference Example 4 (Step (h)) An autoclave having an internal volume of 3 liters was charged with 24.9 g (178 mmols in terms of KOH) of aqueous 40% potassium hydroxide, 1.1 kg (64.7 moles) of liquid ammonia and 0.15 kg (6.25 moles) of acetylene. Thereafter, keeping the temperature inside the autoclave at 4 to 6°C, 340.0 g (1.246 moles) of the phyton obtained in Reference Example 3, i.e., 6,10,14-trimethylpentadecan-2-one, was introduced into the autoclave to initiate the ethynylation. The ethynylation was carried out at 4 to 6°C for 2.5 hours, and then 56.3 g of aqueous 25% ammonium sulfate was introduced into the autoclave to stop the reaction. Thereafter, ammonia was purged off from the autoclave while gradually raising the temperature inside the autoclave to room temperature. Next, 330 g of hexane and 500 g of water were added to the autoclave. A hexane solution containing 3,7,11,15-tetramethyl-1-hexadecyn-3-ol was obtained by collecting the organic layer, followed by washing with water. From this hexane solution, the hexane was removed with a rotary evaporator to give 370 g of crude 3,7,11,15-tetramethyl-1-hexadecyn-3-ol. Analysis by gas chromatography (column: PEG-20M, available from Gasukuro Kogyo Inc.; column length: 3 m; column temperature: 220°C) revealed that the conversion of phyton was 95.4%. An autoclave having an internal volume of 300 ml was charged with 93.4 g of the crude 3,7,11,15-tetramethyl-1-hexadecyn-3-ol thus obtained, 55.6 g of hexane and 0.12 g of a Lindlar catalyst (supported on calcium carbonate) to carry out the hydrogenation for 8 hours under hydrogen pressure of 2.943 to 3.924 bar (3 to 4 kg/cm 2 ) (gauge pressure) at a temperature of 30 to 60°C. The above procedures for the hydrogenation of 3,7,11,15-tetramethyl-1-hexadecyn-3-ol were repeated twice (three times in total) to carry out the hydrogenation of 246.8 g of 3,7,11,15-tetramethyl-1-hexadecyn-3-ol in total. The reaction mixtures obtained were combined, and the catalyst was filtered off. From the resultant filtrate, the hexane was removed with a rotary evaporator to give 262.8 g of crude 3,7,11,15-tetramethyl-1-hexadecen-3-ol, i.e. isophytol. Analysis by gas chromatography (column: DC-550, available from Gasukuro Kogyo Inc.; column length: 3 m; column temperature: 215°C; and column: PEG-20M, available from Gasukuro Kogyo Inc.; column length: 3 m; column temperature: 200°C) revealed that the conversion of 3,7,11,15-tetramethyl-1-hexadecyn-3-ol was 100%. To 262.8 g of the crude isophytol thus obtained, 0.06 g of a methanolic sodium methoxide (concentration: 28%) was added, then the resulting mixture wa heated at 150°C for 1 hour to decompose unreacted 3,7,11,15-tetramethyl-1-hexadecyn-3-ol. Thereafter, the resultant solution was simple distilled under a pressure of 7 x 10 -4 to 9 x 10 -4 bar (0.5 to 0.7 mmHg) to collect 208.7 g of a fraction having a boiling point of 103 to 135°C. Analysis by gas chromatography under the same conditions as the above to revealed that this fraction contained 186.3 % of isophytol (yield on the basis of phyton: 75.7%). This fraction was further purified by distillation to give 124.4 g of isophytol (boiling point: 115-120°C/2 x 10 -4 - 3 x 10 -4 bar (0.15-0.2 mmHg)). Analysis by gas chromatography (column: FFAP, available from Gasukuro Kogyo Inc.; column length: 4 m; column temperature: 195°C) revealed that the isophytol thus obtained had a purity of 99.0%. Example 1 An autoclave made of stainless steel, equipped with a stirrer and having an internal volume of 5 liters, was charged with 732.1 g (12.6 moles) of acetone and 3.1 g of 10% palladium carbon (a hydrogenation catalyst) in an atmosphere of nitrogen. The temperature inside the autoclave was raised to 115°C, then the pressure inside the autoclave reached 3.924 bar (4 kg/cm 2 ) (gauge pressure). Thereafter, hydrogen was introduced into the autoclave to adjust the pressure inside the autoclave at 6.867 bar (7 kg/cm 2 ) (gauge pressure) (pressure of hydrogen: 2.943 bar (3 kg/cm 2 )). Subsequently, 360.0 g (0.18 mole in terms of NaOH) of aqueous 2% sodium hydroxide and 1,033.2 g (12.0 moles) of isovaleraldehyde were each continuously added over a period of 3 hours by means of a feed pump. During the addition, the temperature, of the reaction mixture was kept at 110 to 120°C and also the hydrogen was supplied to keep the pressure inside the autoclave at 6.867 bar (7 kg/cm 2 ) (gauge pressure). After the addition of the aqueous sodium hydroxide and isovaleraldehyde was completed, the reaction mixture was kept at temperatures within the above range and stirred for 1.5 hours to run the reaction to the completion. After cooling to the room temperature, the reaction mixture was filtered to remove the palladium on carbon. Thereafter, the resultant filtrate was stood to separate into two layers, then the organic layer was collected and analyzed by gas chromatography (column: Silicon DC QF1, available from Gasukuro Kogyo Inc.; column temperature: raised from 60 to 200°C; rate of temperature rise: 5°C /min.) to reveal that 1,339.6 g (yield on the basis of isovaleraldehyde: 87.1%) of 6-methyl-2-heptanone was contained in 1,517.3 g of the organic layer. The conversion of isovaleraldehyde was 97.9%, and the selectivity to 6-methyl-2-heptanone was 89.0%. 1,517,3 g of the organic layer thus obtained was distilled under a reduced pressure to give 1,260.5 g of 6-methyl-2-heptanone (b.p.: 103°C/0.133 bar (100 mmHg)). Example 2 An autoclave made of glass, equipped with a stirred and having an internal volume of 1 liter, was charged with 122.0 g (2.1 moles) of acetone and 0.50 g of 10% palladium on carbon (a hydrogenation catalyst). Then, the atmosphere inside the autoclave was replaced with hydrogen of 4.905 bar (5 kg/cm 2 ) (gauge pressure), and the mixture obtained was heated to 65°C. Thereafter, 143.0 g (71.5 mmols in terms of NaOH) of aqueous 2% sodium hydroxide and 172.2 g (2.0 moles) of isovaleraldehyde were each continuously added to the autoclave over a period of 3 hours by means of a feed pump. During the addition, the temperature of the reaction mixture was kept at 65 to 66°C and also the hydrogen was supplied to keep the pressure inside the autoclave at 4.905 bar (5 kg/cm 2 ) (gauge pressure). After the addition of the aqueous sodium hydroxide and isovaleraldehyde was completed, the reaction mixture was kept at temperatures within the above range and stirred for 1.5 hours to run the reaction to the completion. After cooling to the room temperature, the reaction mixture was filtered to remove the palladium on carbon. Thereafter, the resultant filtrate was stood to separate into two layers, then the organic layer was collected, and analyzed by gas chromatography in the same manner as in Example 5 to reveal that 180.4 g (yield on the basis of isovaleraldehyde: 70.4%) of 6-methyl-2-heptanone was contained in 238.7 g of the organic layer. The conversion of isovaleraldehyde was 97.1%, and the selectivity to the 6-methyl-2-heptanone was 72.5%. 238.68 g of the organic layer thus obtained was distilled under a reduced pressure to give 171.3 g of 6-methyl-2-heptanone (b.p.: 103°C/0.133 bar (100 mmHg)). Example 3 An autoclave made of glass, equipped with a stirrer and having an internal volume of 1 liter, was charged with 5.9 g (1.65 moles) of acetone and 0.38 g of Raney nickel (a hydrogenation catalyst). Then, the atmosphere inside the autoclave was replaced with hydrogen of 4.905 bar (5 kg/cm 2 ) (gauge pressure), and the mixture obtained was heated to 55°C. Thereafter, 151.8 g (75.8 mmols in terms of NaOH) of aqueous 2% sodium hydroxide and 129.1 g (1.5 moles) of isovaleraldehyde were each continuously added to the autoclave over a period of 3 hours by means of a feed pump. During the addition, the temperature of the reaction mixture was kept at 59 to 61°C and also the hydrogen was supplied to keep the pressure inside the autoclave at 4.905 bar (5 kg/cm 2 ) (gauge pressure). After the addition of the aqueous sodium hydroxide and isovaleraldehyde was completed, the reaction mixture was kept at temperatures within the above range and stirred for 6 hours to run the reaction to the completion. After cooling to the room temperature, the reaction mixture was filtered to remove the Raney nickel. Thereafter, the resultant filtrate was stood to separate into two layers, then the organic layer was collected and analyzed by gas chromatography in the same manner as in Example 5 to reveal that 113.8 g (yield on the basis of isovaleraldehyde: 59.2%) of 6-methyl-2-heptanone was contained in 166.6 g of the organic layer. The conversion of isovaleraldeheyde was 96.9%, and the selectivity to the 6-methyl-2-heptanone was 61.1%. Example 4 An autoclave made of stainless steel, equipped with a stirrer and having an internal volume of 300 ml, was charged with 43.6 g (0.75 mole) of acetone, 43.1 g (0.5 moles) of isovaleraldehyde and 50.0 g (25 mmols in terms of NaOH) of aqueous 2% sodium hydroxide, and 0.126 g of 10% palladium on carbon (a hydrogenation catalyst) in an atmosphere of nitrogen. Then, the atmosphere inside the autoclave was replaced with hydrogen of 5.886 bar (6 kg/cm 2 ) (gauge pressure). The reaction was conducted for 4 hours while keeping the temperature of the reaction mixture at 60°C and also supplying the hydrogen to keep the pressure inside the autoclave at 5.886 bar (6 kg/cm 2 ) (gauge pressure). After cooling to the room temperature, the reaction mixture was filtered to remove the palladium on carbon. Thereafter, the resultant filtrate was stood to separate into two layers, then the organic layer was collected, and analyzed by gas chromatography in the same manner as in Example 5 to reveal that 42.1 g (yield on the basis of isovaleraldehyde: 65.8%) of 6-methyl-2-heptanone was contained in 66.9 g of the organic layer. The conversion of isovaleraldehyde was 99.7%, and the selectivity to the 6-methyl-2-heptanone was 66.0%. Examples 5 to 10 The procedure of Example 1 was repeated to carry out the reaction, except that the isovaleraldehyde was replaced with the aldehydes as shown in Table 1. Each of the aldehydes, acetone, aqueous 2% sodium hydroxide and palladium on carbon were used in the amounts as shown in Table 1, and the reaction was carried out at a temperature of 120°C under a hydrogen pressure of 6.867 bar (7.0 kg/cm 2 ) and for the time as shown in Table 1 [feed time (time for the addition), run time (time for the further stirring after the addition)]. As the result, 6-methyl-2-heptanone analogues were obtained in the yields as shown in Table 2. Example 11 The procedure of steps (c) to (g) of Reference Example 3 was repeated except that, in the step (c) thereof, the 6-methyl-2-heptanone was replaced with the 6-methyl-2-heptanone obtained in Example 1. As the result, phyton was obtained in the same yield as in Reference Example 3. Example 12 The procedure of Reference Example 4 was repeated except that the phyton obtained in Example 11 was used. As the result, isophytol was obtained in the same yield as in Reference Example 4. Example 13 The procedure of steps (e) to (g) of Reference Example 3 was repeated except that, in the step (e) thereof, the 6,10-dimethyl-5-undece-2-one was replaced with the 6,10-dimethyl-2-undecanone obtained in Example 6. As the result, phyton was obtained in the same yield as in Reference Example 3. Example 14 The procedure of Reference Example 4 was repeated except that the phyton obtained in Example 13 was used. As the result, isophytol was obtained in the same yield as in Reference Example 4. Example 15 The procedure of Reference Example 4 was repeated except that the phyton obtained in Example 10 was used. As the result, isophytol was obtained in the same yield as in Reference Example 4.

Claims: A process for producing a 6-methyl-2-heptanone analogue represented by Formula (1): wherein n is an integer of 0 or 1 to 4; said process comprising the step of allowing hydrogen, acetone and an aldehyde represented by Formula (2): wherein n is as defined above; X and Y each represent a hydrogen atom or they are coupled together to form a carbon-carbon bond; and Z and W each represent a hydrogen atom or they are coupled together to form a carbon-carbon bond; to react in the presence of an aqueous alkali containing an alkaline substance, and a hydrogenation catalyst. The process according to claim 1, wherein said aldehyde of Formula (2) and said aqueous alkali are made to contact with hydrogen gas while each continuously adding the aldehyde and the aqueous alkali in a suspension of the hydrogenation catalyst in the acetone. The process according to claim 1 or 2, wherein said hydrogenation catalyst is palladium on carbon, palladium on alumina, Raney nickel or platinum on carbon. The process according to anyone of claims 1 to 3, wherein said hydrogenation catalyst is used in an amount of from 0.01 to 10% by weight based on the aldehyde of Formula (2). The process according to anyone of claims 1 to 4, wherein in Formulas (1) and (2), n is 0, 1 or 2. The process according to claim 5, wherein at least one of senecioaldehyde and isovaleraldehyde is used as the aldehyde of Formula (2) and 6-methyl-2-heptanone (n is 0) is obtained as the compound of Formula (1). The process according to claim 5, wherein at least one of citral, citronellal and tetrahydrocitral is used as the aldehyde of Formula (2) and 6,10-dimethyl-2-undecanone (n is 1) is obtained as the compound of Formula (1). The process according to claim 5, wherein an aldehyde of Formula (2) where n is 2 is used as the aldeyhde of Formula (2) and phyton is obtained as the compound of Formula (1). The process according to claim 8, wherein the aldehyde of Formula (2) is at least one of farnesal and hexahydrofarnesal. The process according to anyone of claims 1 to 9, wherein the reaction is carried out at a temperature of from 40°C to 140°C. The process according to anyone of claims 1 to 10, wherein said alkaline substance is at least one of an alkali metal hydroxide and an an alkaline earth metal hydroxide. The process according to anyone of claims 1 to 11, wherein said alkaline substance is used in an amount of from 0.001 mole to 0.2 mole per mole of the aldehyde of Formula (2). The process according to claim 12, wherein said alkaline substance is used in an amount of from 0.01 mole to 0.1 mole per mole of the aldehyde of Formula (2). The process according to anyone of claims 1 to 13, wherein said acetone is used in an amount of from 0.8 mole to 2 moles per mole of the aldehyde of Formula (2). The process according to claim 14, wherein said acetone is used in an amount of from 0.9 mole to 1.2 moles per mole of the aldehyde of Formula (2). A process for producing phyton, comprising the steps of: (a) forming 6-methyl-2-heptanone by the process according to claim 6; (b) allowing the 6-methyl-2-heptanone obtained in step (a) to react with a vinyl magnesium halide to effect vinylation, or subjecting the 6-methyl-2-heptanone to ethynylation and successive partial hydrogenation, to form 3,7-dimethyl-1-octen-3-ol; (c) allowing the 3,7-dimethyl-1-octen-3-ol obtained in step (b) to react with diketene or an acetoacetic acid ester to form an acetoacetic acid ester of 3,7-dimethyl-1-octen-3-ol and subjecting the resultant ester to Carroll rearrangement, or allowing the 3,7-dimethyl-1-octen-3-ol to react with an isopropenyl alkyl ether to form an isopropenyl ether of 3,7-dimethyl-1-octen-3-ol and subjecting the resultant ether to Claisen rearrangement, to form 6,10-dimethyl-5-undecen-2-one; (d) allowing the 6,10-dimethyl-5-undecen-2-one obtained in step (c) to react with a vinyl magnesium halide to effect vinylation, or subjecting the 6,10-dimethyl-5-undecen-2-one to ethynylation and successive partial hydrogenation, to form 3,7,11-trimethyl-1,6-dodecadien-3-ol; (e) allowing the 3,7,11-trimethyl-1,6-dodecadien-3-ol obtained in step (d) to react with diketene or an acetoacetic acid ester to form an acetoacetic acid ester of 3,7,11-trimethyl-1,6-dodecadien-3-ol and subjecting the resultant ester to Carroll rearrangement, or allowing the 3,7,11-trimethyl-1,6-dodecadien-3-ol to react with an isopropenyl alkyl ether to form an isopropenyl ether of 3,7,11-trimethyl-1,6-dodecadien-3-ol and subjecting the resultant ether to Claisen rearrangement, to form 6,10,14-trimethyl-5,9-pentadecadien-2-one; and (f) subjecting the 6,10,14-trimethyl-5,9-pentadecadien-2-one obtained in step (e) to hydrogenation to give phyton. A process for producing phyton, comprising the steps of (i) forming 6,10-dimethyl-2-undecanone by the process according to claim 7; and (ii) forming phyton from the 6,10-dimethyl-2-undecanone obtained in step (i) by the following steps (d') to (f'): (d') allowing the 6,10-dimethyl-2-undecanone obtained in step (i) to react with a vinyl magnesium halide to effect vinylation, or subjecting the 6,10-dimethyl-2-undecanone to ethynylation and successive partial hydrogenation, to form 3,7,11-trimethyl-1-dodecen-3-ol; (e') allowing the 3,7,11-trimethyl-1-dodecen-3-ol obtained in step (d') to react with diketene or an acetoacetic acid ester to form an acetoacetic acid ester of 3,7,11-trimethyl-1-dodecen-3-ol and subjecting the resultant ester to Carroll rearrangement, or allowing the 3,7,11-trimethyl-1-dodecen-3-ol to react with an isopropenyl alkyl ether to form an isopropenyl ether of 3,7,11-trimethyl-1-dodecen-3-ol and subjecting the resultant ether to Claisen rearrangement, to form 6,10,14-trimethyl-5-pentadecen-2-one; and (f') subjecting the 6,10,14-trimethyl-5-pentadecen-2-one obtained in step (e') to hydrogenation to give phyton. A process for producing isophytol, comprising the steps of forming phyton by the process according to anyone of claims 8 to 17, and allowing the obtained phyton to react with a vinyl magnesium halide to effect vinylation, or by subjecting the obtained phyton to ethynylation and successive partial hydrogenation, to give isophytol.

Inventors: IWASAKI HIDEHARU, KIDO YOICHI, KUMAGAI NORIAKI, ONISHI TAKASHI, UEYAMA FUYUO, IWASAKI, HIDEHARU, KIDO, YOICHI, KUMAGAI, NORIAKI, ONISHI, TAKASHI, UEYAMA, FUYUO
Applicants: KURARAY CO, KURARAY CO., LTD.
Application year: 1997
Main classification: C07C45
IPC codes: C07C29, C07C45, C07C49