NOVEL CYCLOALKYL SUBSTITUDED IMIDAZOLES

Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy.

Description: NOVEL CYCLOALKYL SUBSTITUTED IMIDAZOLES This invention relates to a novel group of imidazole compounds, processes for the preparation thereof, the use thereof in treating cytokine mediated diseases and pharmaceutical compositions for use in such therapy. BACKGROUND OF THE INVENTION Interleukin- 1 (IL-1) and Tumor Necrosis Factor (TNF) are biological substances produced by a variety of cells, such as monocytes or macrophages. IL-1 has been demonstrated to mediate a variety of biological activities thought to be important in immunoregulation and other physiological conditions such as inflammation [See, e.g., Dinarello et al., Rev. Infect. Disease. 6, 51 (1984)]. The myriad of known biological activities of IL-1 include the activation of T helper cells, induction of fever, stimulation of prostaglandin or collagenase production, neutrophil chemotaxis, induction of acute phase proteins and the suppression of plasma iron levels. There are many disease states in which excessive or unregulated EL- 1 production is implicated in exacerbating and/or causing the disease. These include rheumatoid arthritis, osteoarthritis, endotoxemia and/or toxic shock syndrome, other acute or chronic inflammatory disease states such as the inflammatory reaction induced by endotoxin or inflammatory bowel disease; tuberculosis, atherosclerosis, muscle degeneration, cachexia, psoriatic arthritis, Reiter's syndrome, rheumatoid arthritis, gout, traumatic arthritis, rubella arthritis, and acute synovitis. Recent evidence also links IL-1 activity to diabetes and pancreatic β cells. Dinarello, J. Clinical Immunology. 5 (5), 287-297 (1985), reviews the biological activities which have been attributed to IL-1. It should be noted that some of these effects have been described by others as indirect effects of IL- 1. Excessive or unregulated TNF production has been implicated in mediating or exacerbating a number of diseases including rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; sepsis, septic shock, endotoxic shock, gram negative sepsis, toxic shock syndrome, adult respiratory distress syndrome, cerebral malaria, chronic pulmonary inflammatory disease, silicosis, pulmonary sarcoisosis, bone resorption diseases, reperfusion injury, graft vs. host reaction, allograft rejections, fever and myalgias due to infection, such as influenza, cachexia secondary to infection or malignancy, cachexia, secondary to acquired immune deficiency syndrome (AIDS), AIDS, ARC (AIDS related complex), keloid formation, scar tissue formation, Crohn's disease, ulcerative colitis, or pyresis. AIDS results from the infection of T lymphocytes with Human Immunodeficiency Virus (HIV). At least three types or strains of HIV have been identified, i.e., HIV-1, HIV-2 and HIV-3. AS a consequence of HIV infection, T-cell mediated immunity is impaired and infected individuals manifest severe opportunistic infections and/or unusual neoplasms. HIV entry into the T lymphocyte requires T lymphocyte activation. Other viruses, such as HrV-1, HIV-2 infect T lymphocytes after T Cell activation and such virus protein expression and/or replication is mediated or maintained by such T cell activation. Once an activated T lymphocyte is infected with HIV, the T lymphocyte must continue to be maintained in an activated state to permit HIV gene expression and/or HIV replication. Monokines, specifically TNF, are implicated in activated T-cell mediated HIV protein expression and/or virus replication by playing a role in maintaining T lymphocyte activation. Therefore, interference with monokine activity such as by inhibition of monokine production, notably TNF, in an HIV-infected individual aids in limiting the maintenance of T cell activation, thereby reducing the progression of HIV infectivity to previously uninfected cells which results in a slowing or elimination of the progression of immune dysfunction caused by HIV infection. Monocytes, macrophages, and related cells, such as kupffer and glial cells, have also been implicated in maintenance of the HIV infection. These cells, like T-cells, are targets for viral replication and the level of viral replication is dependent upon the activation state of the cells. [See Rosenberg et al.. The Immunopathogenesis of HIV Infection, Advances in Immunology, Vol. 57, (1989)]. Monokines, such as TNF, have been shown to activate HIV replication in monocytes and/or macrophages [See Poli, et al.. Proc. Natl. Acad. Sci., 87:782-784 (1990)], therefore, inhibition of monokine production or activity aids in limiting HIV progression as stated above for T-cells. TNF has also been implicated in various roles with other viral infections, such as the cytomegalo virus (CMV), influenza virus, and the herpes virus for similar reasons as those noted. Interleukin-8 (IL-8) is a chemotactic factor first identified and characterized in 1987. LL-8 is produced by several cell types including mononuclear cells, fibroblasts, endothelial cells, and keratinocytes. Its production from endothelial cells is induced by IL-1, TNF, or lipopolysaccharide (LPS). Human IL-8 has been shown to act on Mouse, Guinea Pig, Rat, and Rabbit NeutrophilsMany different names have been applied to IL-8, such as neutrophil attractant/activation protein- 1 (NAP-1), monocyte derived neutrophil chemotactic factor (MDNCF), neutrophil activating factor (NAF), and T-cell lymphocyte chemotactic factor. IL-8 stimulates a number of functions in vitro. It has been shown to have chemoattractant properties for neutrophils, T-lymphocytes, and basophils. In addition it induces histamine release from basophils from both normal and atopic individuals as well as lysozomal enzyme release and respiratory burst from neutrophils. IL-8 has also been shown to increase the surface expression of Mac-1 (CD1 lb/CD 18) on neutrophils without de novo protein synthesis, this may contribute to increased adhesion of the neutrophils to vascular endothelial cells. Many diseases are characterized by massive neutrophil infiltration. Conditions associated with an increased in IL-8 production (which is responsible for chemotaxis of neutrophil into the inflammatory site) would benefit by compounds which are suppressive of IL-8 production. LL- 1 and TNF affect a wide variety of cells and tissues and these cytokines as well as other leukocyte derived cytokines are important and critical inflammatory mediators of a wide variety of disease states and conditions. The inhibition of these cytokines is of benefit in controlling, reducing and alleviating many of these disease states. There remains a need for treatment, in this field, for compounds which are cytokine suppressive anti-inflammatory drugs, i.e. compounds which are capable of inhibiting cytokines, such as LL- 1 , IL-6, IL-8 and TNF. SUMMARY OF THE INVENTION This invention relates to the novel compounds of Formula (I) and pharmaceutical compositions comprising a compound of Formula (I) and a pharmaceutically acceptable diluent or carrier. This invention relates to a method of treating a CSBP/RK/p38 kinase mediated disease in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound of Formula (I). This invention also relates to a method of inhibiting cytokines and the treatment of a cytokine mediated disease, in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound of Formula (I). This invention more specifically relates to a method of inhibiting the production of IL- 1 , IL-8 or TNF in a mammal in need thereto, which comprises administering to said mammal an effective amount of a compound of Formula (I). Accordingly, the present invention provides for a compound of the Formula : wherein Rl is 4-pyridyl, pyrimidinyl, quinolyl, isoquinolinyl, quinazolin-4-yl, 1-imidazolyl or 1-benzimidazolyl, which ring is substituted with a substituted C1.4 alkoxy or a substituted Ci-4 alkylthio group, and is additionally optionally substituted independently by C alkyl, halogen, hydroxyl, Ci-4 alkoxy, C]-4 alkylthio, C1-.4 alkylsulfinyl, CH2OR12, amino, mono and di- C\- alkyl substituted amino, N(Rιo)C(O)R c or an N-heterocyclyl ring which ring has from 5 to 7 members and optionally contains an additional heteroatom selected from oxygen, sulfur or NR15; R4 is phenyl, naphth-1-yl or naphth-2-yl, or a heteroaryl, which is optionally substituted by one or two substituents, each of which is independently selected, and which, for a 4-phenyl, 4-naphth-l-yl, 5-naphth-2-yl or 6-naphth-2-yl substituent, is halogen, cyano, nitro, -C(Z)NR7Ri7, -C(Z)ORi6, -(CRioR20)vCORi2, -SR5, -SOR5, -OR12, halo- substituted-Ci-4 alkyl, C1-4 alkyl, -ZC(Z)Ri2, -NRι υ C(Z)Ri6, or -(CRiθR2θ)vNRiθR20 and which, for other positions of substitution, is halogen, cyano, -C(Z)NRi3Rl4. -C(Z)OR3, -(CRioR20)m"COR3, -S(O) m R3, -OR3, halo- substituted-Ci-4 alkyl, -C1-4 alkyl, -(CRιoR2θ)m"NRiθC(Z)R3, -NRιoS(O) m 'R8, -NRioS(O) m -NR7Ri7, -ZC(Z)R3 or -(CRι 0 R20)m"NRl3Rl4; v is 0, or an integer having a value of 1 or 2; m is 0, or the integer 1 or 2; m' is an integer having a value of 1 or 2, m" is 0, or an integer having a value of 1 to 5; Re is hydrogen, Ci-6 alkyl, C3.7 cycloalkyl, aryl, arylCi_4 alkyl, heteroaryl, heteroarylCi-4alkyl, heterocyclyl, or heterocyclylCi-4alkyl C1-4 alkyl; R2 is an optionally substituted C3-7 cycloalkyl, or C3.7cycloalkylC1.10 alkyl; R3 is heterocyclyl, heterocyclylCi-io alkyl or Rs; R5 is hydrogen, -4 alkyl, C2-4 alkenyl, C2-4 alkynyl or NR7R17, excluding the moieties -SR5 being -SNR7R17 and -SOR5 being -SOH; R7 and R17 is each independently selected from hydrogen or C1-4 alkyl or R7 and R17 together with the nitrogen to which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NRi 5; R8 is Ci-io alkyl, halo-substituted Ci-io alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-7 cycloalkyl, C5-7 cycloalkenyl, aryl, arylCi-io alkyl, heteroaryl, heteroarylCi-io alkyl, (CRioR20)nORl l, (CRlθR2θ)nS(O) m Ri8, (CRιoR2θ)nNHS(O) 2 Rl8v (CRio 20)n Rl3Rl4; wherein the aryl, arylalkyl, heteroaryl, heteroaryl alkyl may be optionally substituted; n is an integer having a value of 1 to 10; R9 is hydrogen, -C(Z)Ri 1 or optionally substituted Ci-io alkyl, S(O)2Rl8, optionally substituted aryl or optionally substituted aryl-Ci-4 alkyl; RlO and R20 is ea ch independently selected from hydrogen or Cι_4 alkyl; Rn is hydrogen, or Ri8; Rl2 is hydrogen or Ri6; Rl3 and R14 is each independently selected from hydrogen or optionally substituted Ci-4 alkyl, optionally substituted aryl or optionally substituted aryl-Cι.4 alkyl, or together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9 ; Rl5 is hydrogen, Ci-4 alkyl or C(Z)-Ci-4 alkyl; R 16 is C 1-4 alkyl, halo-substituted-Ci-4 alkyl, or C3..7 cycloalkyl; Rl8 is Ci-io alkyl, C3-7 cycloalkyl, heterocyclyl, aryl, arylCi-io alkyl, heterocyclyl, heterocyclyl-C 1.1 oalkyl, heteroaryl or heteroarylalkyl; Z is oxygen, or sulfur; or a pharmaceutically acceptable salt thereof. DETAILED DESCRIPTION OF THE INVENTION The novel compounds of Formula (I) may also be used in association with the veterinary treatment of mammals, other than humans, in need of inhibition of cytokine inhibition or production. In particular, cytokine mediated diseases for treatment, therapeutically or prophylactically, in animals include disease states such as those noted herein in the Methods of Treatment section, but in particular viral infections. Examples of such viruses include, but are not limited to, lentivirus infections such as, equine infectious anaemia virus, caprine arthritis virus, visna virus, or maedi virus or retrovirus infections, such as but not limited to feline immunodeficiency virus (FLV), bovine immunodeficiency virus, or canine immunodeficiency virus or other retroviral infections. In Formula (I), suitable Ri moieties includes 4-pyridyl, 4-pyrimidinyl, 4-quinolyl, 6-isoquinolinyl, 4-quinazolinyl, 1-imidazolyl and 1-benzimidazolyl, of which the 4-pyridyl, 4-pyrimidinyl and 4-quinolyl are preferred. More preferred is a substituted 4-pyrimidinyl or a substituted 4-pyridyl moiety, and most preferred is a substituted 4-pyrimidinyl ring. The Rl moieties are substituted at least one time by a substituted Ci-4 alkoxy moiety or a substituted Cj-4 alkylthio. A preferred ring placement of the Rj substituent on the 4- pyridyl derivative is the 2-position, such as 2-methoxy-4-pyridyl. A preferred ring placement on the 4-pyrimidinyl ring is also at the 2-position, such as in 2-methoxy- pyrimidinyl. Suitably the Ci-4 alkoxy or C 1.4 alkylthio moiety is substituted on the alkyl chain by halogen, such as fluorine, chlorine, bromine or iodine; hydroxy, such as hydroxyethyoxy; Ci-io alkoxy, such as a methoxymethoxy , S(O)m alkyl, wherein m is 0, 1 or 2; amino, mono & di-substituted amino, such as in the NR7R17 group, i.e. tert- butylaminoethoxy; or where the R7R17 may together with the nitrogen to which they are attached cyclize to form a 5 to 7 membered ring which optionally includes an additional heteroatom selected from O/N/S; Ci-io alkyl, cycloalkyl, or cycloalkyl alkyl group, such as methyl, ethyl, propyl, isopropyl, t-butyl, etc. or cyclopropyl methyl; or halosubstituted Ci- 10 alkyl, such CF3. Preferably the Ri substituents are tertbutylaminoethoxy, or hydroxyethoxy. Suitable additional substituents for the Rl heteroaryl rings are C1-4 alkyl, halo, OH, Ci-4 alkoxy, C1.4 alkylthio, C1-4 alkylsulfinyl, CH2OR12, amino, mono and di-Cj-6 alkyl substituted amino, N(Rιo)C(O)Rc, or an N-heterocyclyl ring which ring has from 5 to 7 members and optionally contains an additional heteroatom selected from oxygen, sulfur or NR15. The alkyl group in the mono- and di-Ci-6 alkyl substituted moiety may be halo substituted, such as in trifluoro- i.e., trifluoromethyl or trifluroethyl. When the Ri optional substituent is N(Rιo)C(O) R c , wherein Rς is hydrogen, Ci-6 alkyl, 03.7 cycloalkyl, aryl, arylCι.4 alkyl, heteroaryl, heteroarylCi-4alkyl, heterocyclyl, or heterocyclylCi-4alkyl Ci-4 alkyl, R c is preferably Ci-6 alkyl; preferably Rio is hydrogen. It is also recognized that the R c moieties, in particular the Ci-6 alkyl group may be optionally substituted, preferably from one to three times, preferably with halogen, such as fluorine, as in trifluoromethyl or trifluroethyl. Suitably, R4 is phenyl, naphth-1-yl or naphth-2-yl, or a heteroaryl, which is optionally substituted by one or two substituents. More preferably R4 is a phenyl or naphthyl ring. Suitable substitutions for R4 when this is a 4-phenyl, 4-naphth-l-yl, 5-naphth-2-yl or 6- naphth-2-yl moiety are one or two substituents each of which are independently selected from halogen, -SR5, -SOR5, -OR12, CF3, or -(CRioR20)vNRio 20. and for other positions of substitution on these rings preferred substitution is halogen, -S(O) m R3, -OR3, CF3, - (CRioR20)m"NRl3Rl4, -NRIQC(Z)R3 and -NRιoS(O) m 'R8- Preferred substituents for the 4-position in phenyl and naphth-1-yl and on the 5-position in naphth-2-yl include halogen, especially fluoro and chloro and -SR5 and -SOR5 wherein R5 is preferably a Ci-2 alkyl, more preferably methyl; of which the fluoro and chloro is more preferred, and most especially preferred is fluoro. Preferred substituents for the 3-position in phenyl and naphth-1-yl rings include: halogen, especially fluoro and chloro; -OR3, especially Ci-4 alkoxy; CF3, NR10R2O. such as amino; -NRιoC(Z)R3, especially -NHCO(Ci-io alkyl); -NRιoS(O) m 'R8, especially -NHSθ2(Cι_ιo alkyl), and -SR3 and -SOR3 wherein R3 is preferably a -2 alkyl, more preferably methyl. When the phenyl ring is disubstituted preferably it is two independent halogen moieties, such as fluoro and chloro, preferably di-chloro and more preferably in the 3, 4-position. It is also preferred that for the 3-position of both the -OR3 and -ZC(Z)R3 moietites, R3 may also include hydrogen. Preferably, the R4 moiety is an unsubstituted or substituted phenyl moiety. More preferably, R4 is phenyl or phenyl substituted at the 4-position with fluoro and or substituted at the 3-position with fluoro, chloro, C1-4 alkoxy, methane-sulfonamido or acetamido, or R4 is a phenyl di-substituted at the 3,4-position independently with chloro or fluoro, more preferably chloro. Most preferably, R4 is a 4-fluorophenyl. In Formula (I), Z is oxygen, or sulfur, preferably oxygen. Suitably, R2 is an optionally substituted C3-7cycloalkyl, or an optionally substituted C3-7cycloalkyl Ci-io alkyl. Preferably R2 is a C3-7cycloalkyl, of which the cycloalkyl group is preferably a C4-7 ring, more preferably a C4 or C6 ring, most preferably a Cfr ring, which ring is optionally substituted. The C3-7cycloalkyl ring may substituted one to three times independently by halogen, such as fluorine, chlorine, bromine or iodine; hydroxy; Ci-io alkoxy, such as methoxy or ethoxy; S(O)m alkyl, wherein m is 0, 1, or 2, such as methyl thio, methylsulfmyl or methyl sulfonyl; S(O) m aryl; cyano; nitro; amino, mono & di-substituted amino, such as in the NR7R17 group, wherein R7 and Ri 7 are as defined in Formula (I); or where the R7R17 may cyclize together with the nitrogen to which they are attached to form a 5 to 7 membered ring which optionally includes an additional heteroatom selected from oxygen, sulfur or NR15 (wherein R15 is as defined for Formula (I)); N(Rιo)C(O)Xi (wherein Rio is as defined for Formula (I), and Xj is Ci-4 alkyl, aryl or arylCi-4alkyl) ; N(Rιo)C(O) aryl; Ci-io alkyl, such as methyl, ethyl, propyl, isopropyl, or t-butyl; optionally substituted Ci-io alkyl wherein the substituents are halogen, (such as CF3), hydroxy, nitro, cyano, amino, mono & di-substituted amino, such as in the NR7R17 group, S(O)m alkyl and S(O)m aryl, wherein m is 0, 1 or 2; optionally substituted Ci-ioalkylene, such as ethylene or propylene; optionally substituted Ci-io alkyne, such as acetylene (ethynyl) or 1-propynyl; C(O)ORl 1 (wherein Rl 1 is as defined in Formula (I)), such as the free acid or methyl ester derivative; the group R a ; -C(O)H; =O; =N-ORi l; -N(H)-OH (or substituted alkyl or aryl derivatives thereof on the nitrogen or the oxime moiety); -N(ORb)- C(O)-Rd; oxirane; an optionally substituted aryl, such as phenyl; an optionally substituted arylCi-4lkyl, such as benzyl or phenethyl; an optionally substituted heterocycle or heterocyclic Cι_4alkyl, and further these aryl, arylalkyl, heterocyclic, and heterocyclic alkyl moieties are optionally substituted one to two times by halogen, hydroxy, Ci-io alkoxy, S(O)m alkyl, cyano, nitro, amino, mono & di-substituted amino, such as in the NR7R17 group, an alkyl, halosubstituted alkyl. Suitably R a is a 1 ,3-dioxyalkylene group of the formula -O-(CH2)s-O-, wherein s is 1 to 3, preferably s is 2 yielding a 1 ,3-dioxyethylene moiety. Suitably Rb is hydrogen, a pharmaceutically acceptable cation, aroyl or a Ci-io alkanoyl group. Suitably R is NR21R22; -^ 1-6'- halosubstituted alkyl 1-6; hydroxy substituted alkyl 1-6; alkenyl 2-6 > aryl or heteroaryl optionally substituted by halogen, alkyl 1-6 , halosubstituted alkyl 1 -6, hydroxyl, or alkoxy \.(,. Suitably R21 is H or alkyl 1 -6. Suitably R22 i H, alkyl ι_6, aryl, benzyl, heteroaryl, alkyl substituted by halogen or hydroxyl, or phenyl substituted by a member selected from the group consisting of halo, cyano, alkyl \_ γ , alkoxy 1.5, halosubstituted alkyl ι_6, alkylthio, alkylsulphonyl, or alkylsulfmyl; or R21 and R22 may together with the nitrogen to which they are attached form a ring having 5 to 7 members, which members may be optionally replaced by a heteroatom selected from oxygen, sulfur or nitrogen. The ring may be saturated or contain more than one unsaturated bond. Preferably R6 is NR21R22, and more preferably R21 and R22 are hydrogen. A preferred ring placement on the cyclohexyl ring, particularly when it is a C6 ring, is the 4-position. When the cyclohexyl ring is disubstituted it is preferably disubstituted at the 4 position, such as in: wherein R 1 ' and R^' are independently the optional substitutents indicated above for R2- Preferably, R* and R^ are hydrogen, hydroxy, alkyl, substituted alkyl, optionally substituted alkynyl, aryl, arylalkyl, NR7R17, and N(Rιo)C(O)Rι 1. Suitably, alkyl is Ci-4 alkyl, such as methyl, ethyl, or isopropyl; NR7R17 and NR7R17 alkyl, such as amino, methylamino, aminomethyl, aminoethyl; substituted alkyl such as in cyanomethyl, cyanoethyl, nitroethyl, pyrrolidinyl; optionally substituted alkynyl, such as propynyl or ethynyl; aryl such as in phenyl; arylalkyl, such as in benzyl; or together R^ and R^ are a keto functionality. As used herein, "optionally substituted" unless specifically defined herein, shall mean such groups as halogen, such as fluorine, chlorine, bromine or iodine; hydroxy; hydroxy substituted Ci-ioalkyl; Ci-io alkoxy, such as methoxy or ethoxy; S(O)m alkyl, wherein m is 0, 1 or 2, such as methyl thio, methylsulfinyl or methyl sulfonyl; amino, mono & di-substituted amino, such as in the NR7R17 group; or where the R7R17 may together with the nitrogen to which they are attached cyclize to form a 5 to 7 membered ring which optionally includes an additional heteroatom selected from O/N/S; Ci-io alkyl, cycloalkyl, or cycloalkyl alkyl group, such as methyl, ethyl, propyl, isopropyl, t-butyl, etc. or cyclopropyl methyl; halosubstituted Ci-io alkyl, such CF3; halosubstituted Ci-io alkoxy; an optionally substituted aryl, such as phenyl, or an optionally substituted arylalkyl, such as benzyl or phenethyl, wherein these aryl moieties may also be substituted one to two times by halogen; hydroxy; hydroxy substituted alkyl; Ci-io alkoxy; S(O) m alkyl; amino, mono & di-substituted amino, such as in the NR7R17 group; alkyl, or CF3. Suitable pharmaceutically acceptable salts are well known to those skilled in the art and include basic salts of inorganic and organic acids, such as hydrochloric acid, hydrobromic acid, sulphuric acid, phosphoric acid, methane sulphonic acid, ethane sulphonic acid, acetic acid, malic acid, tartaric acid, citric acid, lactic acid, oxalic acid, succinic acid, fumaric acid, maleic acid, benzoic acid, salicylic acid, phenylacetic acid and mandelic acid. In addition, pharmaceutically acceptable salts of compounds of Formula (I) may also be formed with a pharmaceutically acceptable cation, for instance, if a substituent group comprises a carboxy moiety. Suitable pharmaceutically acceptable cations are well known to those skilled in the art and include alkaline, alkaline earth, ammonium and quaternary ammonium cations. The following terms, as used herein, refer to: • "halo" or "halogens", include the halogens: chloro, fluoro, bromo and iodo. • "Cι_ιoalkyl" or "alkyl" - both straight and branched chain radicals of 1 to 10 carbon atoms, unless the chain length is otherwise limited, including, but not limited to, methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, wo-butyl, tert-butyl, n-pentyl and the like. • The term "cycloalkyl" is used herein to mean cyclic radicals, preferably of 3 to 8 carbons, including but not limited to cyclopropyl, cyclopentyl, cyclohexyl, and the like. • The term "cycloalkenyl" is used herein to mean cyclic radicals, preferably of 5 to 8 carbons, which have at least one bond including but not limited to cyclopentenyl, cyclohexenyl, and the like. • The term "alkenyl" is used herein at all occurrences to mean straight or branched chain radical of 2-10 carbon atoms, unless the chain length is limited thereto, including, but not limited to ethenyl, 1-propenyl, 2-propenyl, 2-methyl-l-propenyl, 1-butenyl, 2-butenyl and the like. • "aryl" - phenyl and naphthyl; • "heteroaryl" (on its own or in any combination, such as "heteroaryloxy", or "heteroaryl alkyl") - a 5-10 membered aromatic ring system in which one or more rings contain one or more heteroatoms selected from the group consisting of N, O or S, such as, but not limited, to pyrrole, pyrazole, furan, thiophene, quinoline, isoquinoline, quinazolinyl, pyridine, pyrimidine, oxazole, thiazole, thiadiazole, triazole, imidazole, or benzimidazole. • "heterocyclic" (on its own or in any combination, such as "heterocyclylalkyl") - a saturated or partially unsaturated 4-10 membered ring system in which one or more rings contain one or more heteroatoms selected from the group consisting of N, O, or S; such as, but not limited to, pyrrolidine, piperidine, piperazine, morpholine, tetrahydropyran, or imidazolidine. • The term "aralkyl" or "heteroarylalkyl" or "heterocyclicalkyl" is used herein to mean Ci-4 alkyl as defined above attached to an aryl, heteroaryl or heterocyclic moiety as also defined herein unless otherwise indicate. • "sulfinyl" - the oxide S (O) of the corresponding sulfide, the term "thio" refers to the sulfide, and the term "sulfonyl" refers to the fully oxidized S(O)2 moiety. • "aroyl" - a C(O)Ar, wherein Ar is as phenyl, naphthyl, or aryl alkyl derivative such as defined above, such group include but are note limited to benzyl and phenethyl. • "alkanoyl" - a C(O)Cι_ιo alkyl wherein the alkyl is as defined above. It is recognized that the compounds of the present invention may exist as stereoisomers, regioisomers, or diastereiomers. These compounds may contain one or more asymmetric carbon atoms and may exist in racemic and optically active forms. All of these compounds are included within the scope of the present invention. Exemplified compounds of Formula (I) include: -[2-(2-Hydroxyethoxy)pyrimidin-4-yl]-4-(4-fluorophenyl)-l-(4-oxocyclohexyl)- imidazole; 5-[2-(2-Hydroxyethoxy)]pyrimidin-4-yl)-4-(4-fluorophenyl)-l-(4-hydroxy cyclohexyl)- imidazole; 5-[2-(2-t-?rt-Butylamino)ethoxypyrimidin-4-yl]-4-(4-fluorophenyl)-l-(4-oxocyclohexyl)- imidazole; 5-[2-(2-tert-Butylamino)ethoxypyrimidin-4-yl]-4-(4-fluorophenyl)-l-(4-hydroxy- cyclohexyl)imidazole; or a pharmaceutically acceptable salt thereof. The compounds of Formula (I) may be obtained by applying synthetic procedures, some of which are illustrated in Schemes I to XI below. The synthesis provided for in these Schemes is applicable for the producing compounds of Formula (I) having a variety of different Ri, R2, and R4 groups which are reacted, employing optional substituents which are suitably protected, to achieve compatibility with the reactions outlined herein. Subsequent deprotection, in those cases, then affords compounds of the nature generally disclosed. Once the imidazole nucleus has been established, further compounds of Formula (I) may be prepared by applying standard techniques for functional group interconversion, well known in the art. For instance: -C(O)NRi3Ri4 from -CO2CH3 by heating with or without catalytic metal cyanide, e.g. NaCN, and HNR13R14 in CH3OH; -OC(O)R3 from -OH with e.g., ClC(O)R3 in pyridine; -NRιo-C(S)NRi3Ri4 from -NHR10 with an alkylisothiocyante or thiocyanic acid; NRόC(O)OR6 from -NHR6 with the alkyl chloroformate; NRιoC(O)NRi3Ri4 from -NHR10 by treatment with an isocyanate, e.g. HN=C=O or Rl 0 N=C=O; -NRιo-C(O)R8 from -NHR10 by treatment with Cl-C(O)R3 in pyridine; -C(=NRιo)NRi3Ri4 from -C(NRi3Ri4)SR3 with H3NR3+OAc" by heating in alcohol; -C(NRi3Ri4)SR3 from -C(S)NRi3Ri4 with R6-I in an inert solvent, e.g. acetone; -C(S)NRi3Ri4 (where R13 or R14 is not hydrogen) from -C(S)NH2 with HNRi3Ri4-C(=NCN)-NRi3Ri4 from -C(=NRi3Ri4)-SR3 with NH2CN by heating in anhydrous alcohol, alternatively from -C(=NH)-NRi3Ri4 by treatment with BrCN and NaOEt in EtOH; from -NHR10 by treatment with -NR10SO2R3 from -NHR10 by treatment with CISO2R3 by heating in pyridine; NRιoC(S)R3 from -NRιoC(O)Rs by treatment with Lawesson's reagent [2,4-bis(4- methoxyphenyl)-l,3,2,4-dithiadiphosphetane-2,4-disulfide]; -NR10SO2CF3 from -NHR6 with triflic anhydride and base wherein R3, R6, RlO, Rl3 and R 14 are as defined in Formula (I) herein. In a further aspect the present invention provides for compounds of the Formula (II) having the structure: wherein p is 0, or 2; R4 is as defined for Formula (I) and Ar is an optionally substituted aryl as defined herein. Suitably, Ar is phenyl optionally substituted by Cι_4alkyl, C .4 alkoxy or halo. Preferably Ar is phenyl or 4-methylphenyl, i.e. a tosyl derivative. Compounds of Formula (II) are belived novel, provided than when Ar is tosyl, and p is 0 or 2, then R4 is not an unsubstituted phenyl. Precursors of the groups Rj, R2 and R4 can be other Rl, R2 and R4 groups which can be interconverted by applying standard techniques for functional group interconversion. For example a compound of the formula (I) wherein R2 is halo -substituted C\.\Q alkyl can be converted to the corresponding Cι_ιo alkylN3 derivative by reacting with a suitable azide salt, and thereafter if desired can be reduced to the corresponding C _iQalkylNH2 compound, which in turn can be reacted with Ri S(0)2X wherein X is halo (e.g., chloro) to yield the corresponding Cι_ιoalkylNHS(0)2Ri8 compound. Alternatively a compound of the formula (I) where R2 is halo-substituted Cι_ιo-alkyl can be reacted with an amine R13R14NH to yield the corresponding Cι_ιo-alkylNRi3Ri4 compound, or can be reacted with an alkali metal salt of RisSH to yield the corresponding Cι_ιoalkylSRi compound. R 4 CHO agent SCHEME I Referring to Scheme I the compounds of Formula (I) are suitably prepared by reacting a compound of the Formula (II) with a compound of the Formula (LU) wherein p is 0 or 2, Rj, R2 and R4 are as defined herein, for Formula (I), or are precursors of the groups R , R2 and R4, and Ar is an optionally substituted phenyl group, and thereafter if necessary converting a precursor of Ri, R2 and R4 to a group Ri, R2 and R4. It is recognized that R2NH2 which is reacted with RiCHO to form the imine, Formula (III) the R2 moiety when it contains a reactive functional group, such as a primary or secondary amine, an alcohol, or thiol compound the group must be suitably protected. Suitable protecting groups may be found in, Protecting Groups in Organic Synthesis, Greene T W, Wiley-Interscience, New York, 1981, whose disclosure is incoφorated herein by reference. For instance, when R2 is contains as a substituent group a heterocyclic ring, such as a piperidine ring, the nitrogen is protected with groups such as t-Boc, CO2RI8. or a substitued arylalkyl moiety. Suitably, the reaction is performed at ambient temperature or with cooling (e.g. -50° to 10°) or heating in an inert solvent such as methylene chloride, DMF, tetrahydrofuran, toluene, acetonitrile, or dimethoxyethane in the presence of an appropriate base such as 1,8- diazabicyclo [5.4.0.] undec-7-ene (DBU) or a guanidine base such as 1,5,7-triaza-bicyclo [4.4.0] dec-5-ene (TBD). The intermediates of formula (II) have been found to be very stable and capable of storage for a long time. Preferably, p is 2. Reaction a compound of the Formula (II) wherein p = 2, with a compound of the Formula (IΙI)-Scheme I gives consistently higher yields of compounds of Formula (I) than when p=0. In addition, the reaction of Formula (II) compounds wherein p = 2 is more environmentally and economically attractive. When p=0, the preferred solvent used is methylene chloride, which is environmentally unattractive for large scale processing, and the preferred base, TBD, is also expensive, and produces some byproducts and impurities, than when using the commercially attractive synthesis (p=2) as further described herein. As noted, Scheme I utilizes the 1 ,3-dipolar cycloadditions of an anion of a substituted aryl thiomethylisocyanide (when p=0) to an imine. More specifically, this reaction requires a strong base, such as an amine base, to be used for the deprotonation step. The commercially available TBD is preferred although t-butoxide, Li+ or Na+, or K+ hexamethyldisilazide may also be used. While methylene chloride is the prefered solvent, other halogenated solvents, such as chloroform or carbon tetrachloride; ethers, such as THF, DME, DMF, diethylether, t-butyl methyl ether; as well as acetonitrile, toluene or mixtures thereof can be utiltized. The reaction may take place from about -20°C to about; 40°C, preferably from about 0°C to about 23 °C, more preferably from about 0°C to about 10°C, and most preferably about 4°C for reactions involving an Ri group of pyrimidine. For compounds wherein Ri is pyridine, it is recognized that varying the reations conditions of both temperature and solvent may be necessary, such as decreasing temperatures to about - 50°C or changing the solvent to THF. In a further process, compounds of Formula (I) may be prepared by coupling a suitable derivative of a compound of Formula (IX): wherein Ti is hydrogen and T4 is R4 , or alternatively Ti is Ri and T4 is H in which Ri, R2 and R4 are as hereinbefore defined; with: (i) when Ti is hydrogen, a suitable derivative of the heteroaryl ring RlH, under ring coupling conditions, to effect coupling of the heteroaryl ring Ri to the imidazole nucleus at position 5; (ii) when T4 is hydrogen, a suitable derivative of the aryl ring R4H, under ring coupling conditions, to effect coupling of the aryl ring R4 to the imidazole nucleus at position 4. Such aryl/heteroaryl coupling reactions are well known to those skilled in the art. In general, an organometallic synthetic equivalent of an anion of one component is coupled with a reactive derivative of the second component, in the presence of a suitable catalyst. The anion equivalent may be formed from either the imidazole of Formula (IX), in which case the aryl/heteroaryl compound provides the reactive derivative, or the aryl/heteroaryl compound in which case the imidazole provides the reactive derivative. Accordingly, suitable derivatives of the compound of Formula (LX) or the aryl/heteroaryl rings include organometallic derivatives such as organomagnesium, organozinc, organostannane and boronic acid derivatives and suitable reactive derivatives include the bromo, iodo, fluorosulfonate and trifluoromethanesulphonate derivatives. Suitable procedures are described in WO 91/19497, the disclosure of which is incorporated by reference herein. Suitable organomagnesium and organozinc derivatives of a compound of Formula (IX) may be reacted with a halogen, fluorosulfonate or triflate derivative of the heteroaryl or aryl ring, in the presence of a ring coupling catalyst, such as a palladium (O) or palladium (II) catalyst, following the procedure of Kumada et a\., Tetrahedron Letters, 22, 5319 (1981). Suitable such catalysts include tetrα/tø-(triphenylphosphine)palladium and PdCl2[l,4-fci.s-(diphenylphosphino)-butane], optionally in the presence of lithium chloride and a base, such as triethylamine. In addition, a nickel (II) catalyst, such as Ni(II)Cl2(l,2- biphenylphosphino)ethane, may also be used for coupling an aryl ring, following the procedure of Pridgen et al., J. Org. Chem, 1982, 47, 4319. Suitable reaction solvents include hexamethylphosphor-amide. When the heteroaryl ring is 4-pyridyl, suitable derivatives include 4-bromo- and 4-iodo-pyridine and the fluorosulfonate and triflate esters of 4-hydroxy pyridine. Similarly, suitable derivatives for when the aryl ring is phenyl include the bromo, fluorosulfonate, triflate and, preferably, the iodo-derivatives. Suitable organomagnesium and organozinc derivatives may be obtained by treating a compound of Formula (LX) or the bromo derivative thereof with an alkyllithium compound to yield the corresponding lithium reagent by deprotonation or transmetallation, respectively. This lithium intermediate may then be treated with an excess of a magnesium halide or zinc halide to yield the corresponding organometallic reagent. A trialkyltin derivative of the compound of Formula (IX) may be treated with a bromide, fluorosulfonate, triflate, or, preferably, iodide derivative of an aryl or heteroaryl ring compound, in an inert solvent such as tetrahydrofuran, preferably containing 10% hexamethylphosphoramide, in the presence of a suitable coupling catalyst, such as a palladium (0) catalyst, for instance tetrørαs-(triphenylphosphine)-palladium, by the method described in by Stille, J. Amer. Chem. Soc, 1987, 109, 5478, US Patents 4,719,218 and 5,002,942, or by using a palladium (II) catalyst in the presence of lithium chloride optionally with an added base such as triethylamine, in an inert solvent such as dimethyl formamide. Trialkyltin derivatives may be conveniently obtained by metallation of the corresponding compound of Formula ( C) with a lithiating agent, such as s-butyl-lithium or n-butyllithium, in an ethereal solvent, such as tetrahydrofuran, or treatment of the bromo derivative of the corresponding compound of Formula (IX) with an alkyl lithium, followed, in each case, by treatment with a trialkyltin halide. Alternatively, the bromo- derivative of a compound of Formula (IX) may be treated with a suitable heteroaryl or aryl trialkyl tin compound in the presence of a catalyst such as tetrα&is-(triphenyl-phosphine)-palladium, under conditions similar to those described above. Boronic acid derivatives are also useful. Hence, a suitable derivative of a compound of Formula (IX), such as the bromo, iodo, triflate or fluorosulphonate derivative, may be reacted with a heteroaryl- or aryl-boronic acid, in the presence of a palladium catalyst such as tetrα/c Λ-(triphenylphosphine)-palladium or PdCl2[l,4-b s-(diphenyl-phosphino)-butane] in the presence of a base such as sodium bicarbonate, under reflux conditions, in a solvent such as dimethoxyethane (see Fischer and Haviniga, Rec. Trav. Chim. Pays Bas, 84, 439, 1965, Snieckus, V., Tetrahedron Lett., 29, 2135, 1988 and Terashimia, M., Chem. Pharm. Bull., 11, 4755, 1985). Non-aqueous conditions, for instance, a solvent such as DMF, at a temperature of about 100°C, in the presence of a Pd(II) catalyst may also be employed (see Thompson W J et al, J Org Chem, 49, 5237, 1984). Suitable boronic acid derivatives may be prepared by treating the magnesium or lithium derivative with a trialkylborate ester, such as triethyl, tri-wo-propyl or tributylborate, according to standard procedures. In such coupling reactions, it will be readily appreciated that due regard must be exercised with respect to functional groups present in the compounds of Formula (DC). Thus, in general, amino and sulfur substituents should be non-oxidised or protected. Compounds of Formula (IX) are imidazoles and may be obtained by any of the procedures herein before described for preparing compounds of Formula (I). In particular, an α-halo-ketone or other suitably activated ketones R4COCH2Hal (for compounds of Formula (IX) in which Ti is hydrogen) or RιCOCH2Hal (for compounds of Formula (IX) in which T4 is hydrogen) may be reacted with an amidine of the formula R2NH-C=NH, wherein R2 is as defined in Formula (I), or a salt thereof, in an inert solvent such as a halogenated hydrocarbon solvent, for instance chloroform, at a moderately elevated temperature, and, if necessary, in the presence of a suitable condensation agent such as a base. The preparation of suitable α-halo-ketones is described in WO 91/19497. Suitable reactive esters include esters of strong organic acids such as a lower alkane sulphonic or aryl sulphonic acid, for instance, methane or p-toluene sulphonic acid. The amidine is preferably used as the salt, suitably the hydrochloride salt, which may then be converted into the free amidine in situ , by employing a two phase system in which the reactive ester is in an inert organic solvent such as chloroform, and the salt is in an aqueous phase to which a solution of an aqueous base is slowly added, in dimolar amount, with vigorous stirring. Suitable amidines may be obtained by standard methods, see for instance, Garigipati R, Tetrahedron Letters, 190, 31, 1989. Compounds of Formula (I) may also be prepared by a process which comprises reacting a compound of Formula (IX), wherein Ti is hydrogen, with an N-acyl heteroaryl salt, according to the method disclosed in US patent 4,803,279; US patent 4,719,218 and US patent 5,002,942, to give an intermediate in which the heteroaryl ring is attached to the imidazole nucleus and is present as a 1,4-dihydro derivative thereof, which intermediate may then be subjected to oxidative-deacylation conditions (Scheme II). The heteroaryl salt, for instance a pyridinium salt, may be either preformed or, more preferably, prepared in situ by adding a substituted carbonyl halide (such as an acyl halide, an aroyl halide, an arylalkyl haloformate ester, or, preferably, an alkyl haloformate ester, such as acetyl bromide, benzoylchloride, benzyl chloroformate, or, preferably, ethyl chloroformate) to a solution of the compound of Formula (IX) in the heteroaryl compound RiH or in an inert solvent such as methylene chloride to which the heteroaryl compound has been added. Suitable deacylating and oxidising conditions are described in U.S. Patent Nos. 4,803,279, 4,719,218 and 5,002,942, which references are hereby incoφorated by reference in their entirety. Suitable oxidizing systems include sulfur in an inert solvent or solvent mixture, such as decalin, decalin and diglyme, p-cymene, xylene or mesitylene, under reflux conditions, or, preferably, potassium t-butoxide in t-butanol with dry air or oxygen. S decalm. Δ or K -butoxide/a.r SCHEME II In a further process, illustrated in Scheme III below, compounds of Formula (I) may be prepared by treating a compound of Formula (X) thermally or with the aid of a cyclising agent such as phosphorus oxychloride or phosphorus pentachloride (see Engel and Steglich, Liebigs Ann Chem, 1978, 1916 and Strzybny et al., J Org Chem, 1963, 28, 3381). Compounds of Formula (X) may be obtained, for instance, by acylating the corresponding α-keto-amine with an activated formate derivative such as the corresponding anhydride, under standard acylating conditions followed by formation of the imine with R 2 NH 2 . The aminoketone may be derived from the parent ketone by oxamination and reduction and the requisite ketone may in turn be prepared by decarboxylation of the beta-ketoester obtained from the condensation of an aryl (heteroaryl) acetic ester with the RjCOX component. Rι- ^o 1.) NaOMβ 2.) HCl e formula (X) SCHEME III In Scheme IV illustrated below, two (2) different routes which use ketone (formula XI) for preparing a compound of Formula (I). A heterocyclic ketone (XI) is prepared by 0 adding the anion of the alkyl heterocycle such as 4-methyl-quinoline (prepared by treatment thereof with an alkyl lithium, such as n-butyl lithium) to an N-alkyl-O-alkoxybenzamide, ester, or any other suitably activated derivative of the same oxidation state. Alternatively, the anion may be condensed with a benzaldehyde, to give an alcohol which is then oxidised to the ketone (XI). 5 SCHEME IV In a further process, N-substituted compounds of Formula (I) may be prepared by treating the anion of an amide of Formula (XII): R1CH2NR2COH (XII) wherein Ri and R2 with: (a) a nitrile of the Formula (XIII): R4CN (Xffl) wherein R4 is as hereinbefore defined, or (b) an excess of an acyl halide, for instance an acyl chloride, of the Formula (XIV): R4COHal (XIV) wherein R4 is as hereinbefore defined and Hal is halogen, or a corresponding anhydride, to give a fcis-acylated intermediate which is then treated with a source of ammonia, such as ammonium acetate. (XII) SCHEME V One variation of this approach is illustrated in Scheme V above. A primary amine (R2NH2) is treated with a halomethyl heterocycle of Formula R1CH2X to give the secondary amine which is then converted to the amide by standard techniques. Alternatively the amide may be prepared as illustrated in scheme V by alkyiation of the formamide with R1CH2X. Deprotonation of this amide with a strong amide base, such as lithium di-wo-propyl amide or sodium b/s-(trimethylsilyl)amide, followed by addition of an excess of an aroyl chloride yields the bis-acylated compound which is then closed to an imidazole compound of Formula (I), by heating in acetic acid containing ammonium acetate. Alternatively, the anion of the amide may be reacted with a substituted aryl nitrile to produce the imidazole of Formula (I) directly. The following description and schemes are further exemplification of the process as previously described above in Scheme I. Various pyrimidine aldehyde derivatives 6, 7 and 8 as depicted in scheme VI below, can be prepared by modification of the procedures of Bredereck et al. (Chem. Ber. 1964, 97, 3407) whose disclosure is incoφorated by reference herein. These pyrimidine aldehydes are then utilized as intermediates in the synthesis as further described herein. The unprotected amino aldehyde derivative, e.g. 8, can be somewhat unstable. Use of an acetolysis procedure, as described in Scheme VI, wherein the aldehyde 7 is isolated as the acetamide derivative, (compound 3 is converted to 7, via the intermediate 4) and leads to a more stable compound for use in the cycloaddition reaction to make compounds of Formula (I). General acetolysis conditions, for such a reaction are employed and are well known to those of skill in the art. Suitable conditions are exemplified, for instance in Example 83. In greater detail, the reaction employs heating the 2-amino pyrimidine dialkoxy acetal with acetic anhydride in the presence of a catalytic amount of concentrated sulfuric acid, which simultaneously acetylates the amine and leads to the exchange of one of the alkoxy groups for an acetoxy group. The resultant compound is converted to the aldehyde by deacetylation with a catalytic amount of an alkoxide salt and the corresponding alcohol solvent, e.g. Na+ methoxide and methanol. Alternatively, higher yields can be obtained by first acetylating the amine with acetic anhydride and then affecting exchange by subsequent addition of concentrated sulfuric acid. SCHEME VI The reaction of imines with tosylmethyl isonitriles was first reported by van Leusen (van Leusen, et al., J. Org. Chem. 1977, 42, 1153.) Reported were the following conditions: tert butyl amine(tBuNH2) in dimethoxyethane (DME), K2CO3 in MeOH, and NaH in DME. Upon re-examination of these conditions each was found produce low yields. A second pathway involving amine exchange to produce the t-butyl imine followed by reaction with the isocyanide to produce a 1-tBu imidazole was also operating. This will likely occur using any primary amine as a base. The secondary amines, while not preferred may be used, but may also decompose the isonitrile slowly. Reactions will likely require about 3 equivalents of amine to go to completion, resulting in approximately 50% isolated yields. Hindered secondary amines (diisopropylamine) while usable are very slow and generally not too effective. Use of tertiary and aromatic amines, such as pyridine, and triethylamine gave no reaction under certain test conditions, but more basic types such as DBU, and 4-dimethylamino pyridine (DMAP) while slow, did produce some yields and hence may be suitable for use herein. As depicted in Schemes VII and VIII below, the pyrimidine aldehydes of Scheme VI, can be condensed with a primary amine, to generate an imine, which may suitably be isolated or reacted in situ, with the desired isonitrile in the presence of a variety of suitable bases, and solvents as described herein to afford the 5-(4-pyrimidinyl)-imidazoles, wherein R2 and R4 are as defined herein for Formula (I) compounds. One preferred method for preparing compounds of Formula (I) is shown below in Scheme VII. The imines, prepared and isolated in a separate step where often tars, which were hard to handle. The black color was also often carried over into the final product. The yields, for making the imines varied, and environmentally less-acceptable solvents, such as CH2CI2 were often used in their preparation. This reaction, wherein p=2 requires a suitable base for the reaction to proceed. The reaction requires a base strong enough to deprotonate the isonitrile. Suitable bases include an amine, a carbonate, a hydride, or an alkyl or aryl lithium reagent; or mixtures thereof. Bases include, but are not limited to, potassium carbonate, sodium carbonate, primary and secondary amines, such as t-butylamine, diisopropyl amine, moφholine, piperidine, pyrrolidine, and other non-nucleophilic bases, such as DBU, DMAP and 1,4- diazabicyclo[2.2.2]octane (DABCO). Suitable solvents for use herein, include but are not limited to N,N-dimethyl- formamide (DMF), MeCN, halogenated solvents, such as methylene chloride or chloroform, tetrahydrofuran (THF), dimethylsulfoxide (DMSO), alcohols, such as methanol or ethanol, benzene, toluene, DME or EtOAc. Preferably the solvent is DMF, DME, THF, or MeCN, more preferably DMF. Product isolation may generally be accomplished by adding water and filtering the product as a clean compound. The mixture is non-nucleophilic, thus no isonitrile decomposition occurs. SCHEME VIT While not convenient for large scale work, addition of NaH, instead of t-butylamine, to the isonitrile, perhaps with temperatures lower than 25 °C (in THF) are likely needed. Additionally, BuLi has also been reported to be an effective base for deprotonating tosyl benzylisonitriles at -50 °C. (DiSanto, et al., Synth. Commun. 1995, 25, 795). Various temperature conditions may be utilized depending upon the preferred base. For instance, tBuNH2/DME, K2CO3/MeOH, K2CO3 in DMF, at temperatures above 40°C, the yields may drop to about 20% but little difference is expected between 0°C and 25°C. Consequently, temperature ranges below 0 °C, and above 80 °C are contemplated as also being within the scope of this invention. Preferably, the temperature ranges are from about 0°C to about 25°C. For puφoses herein, room tempature, which is depicted as 25°C, but it is recognized that this may vary from 20°C to 30°C. As shown in Scheme VIII below, the imine is preferably formed in situ in a solvent. This preferred synthesis, is a process which occurs as a one-pot synthesis. Suitably, when the primary amine is utilized as a salt, such as in the dihydrochloride salt in the Examples, the reaction may further include a base, such as potassium carbonate prior to the addition of the isonitrile. Alternatively, the piperidine nitrogen may be required to be protected as shown below. Reaction conditions, such as solvents, bases, temperatures, etc. are similar to those illustrated and discussed above for the isolated imine as shown in Scheme VIII. One skilled in the art would readily recognize that under some circumstances, the in situ formation of the imine may require dehydrating conditions, or may require acid catalysis. SCHEME VIII Another method for preparing compounds of Formula (I) is shown below in Scheme VIHa. To avoid the difficulty associated with isolating the pyrimidine aldehyde 8, it is possible to hydrolyze the acetal 3 to aldehyde 8 as described herein. The aldehyde 8, formed in situ, can be treated sequentially with a primary amine, ethyl acetate, and NaHCO 3 to form the corresponding imine in situ, which is extracted into the ethyl acetate. Addition of the isonitrile, a carbonate base and DMF allows for the formation of the 5-(4- pyrimidinyl)-imidazoles, wherein R2 and R4 are as defined herein for Formula (I) compounds. While it is recognized that Schemes VII, VIII, and VΙII(a) are shown using a piperidine ring in the R2 position this is for illustration puφoses only and any suitable R2 as defined herein may be utilized. EtOAc x = o/s SCHEME Vflla The preferred method of synthesis for compounds of Formula (I) also provides for a suitable and reliable method for introduction of an S(O)malkyl moiety on the pyrimidine (Rl group) by using, for instance, the 2-methylthio pyrimidine aldehyde derivative, as is also described in the Examples section. In scheme IX below (X=S Methyl), compound 1, while a final product may also be used as a precursor, as previously noted to make further compounds of formula (I). In this particular instance the methylthio moiety is oxidized to the methyl sulfinyl moiety which may additionally be further modified to a substituted amino group. SCHEME IX Another embodiment of the present invention is the novel hydrolysis of 2- thiomethylpyrimidine acetal to 2-thiomethylpyrimidine aldehyde, as shown in Scheme X below. Hydrolysis of the acetal to aldehyde using various known reaction conditions, such as formic acid, did not produce a satisfactory yield of the aldehyde, <13%) was obtained. The preferred synthesis involves the use of AcOH (fresh) as solvent and concentrated H2SO4 under heating conditions, preferably a catalytic amount of sulfuric acid. Heating conditions include temperatures from about 60 to 85°C, preferably from about 70° to about 80°C as higher temperatures show a darkening of the reaction mixture. After the reaction is completed the mixture is cooled to about room temperature and the acetic acid is removed. An alternative procedure to this involves heating the acetal in 3N HCL at 40°C for about 18 hours, cooling and extracting the bicarbonate neutralized solution into EtOAc. X = O/S SCHEME X The final 2-aminopyrimidin-4-yl imidazole compounds of Formula (I), as well as similar pyridine containing compounds can be prepared by one of three methods: 1) direct reaction of the 2-aminopyrimidine imine with the isonitrile; 2) condensation of the 2- acetamidopyrimidine imine with the isonitrile followed by removal of the acetamido group and 3) oxidation of the 2-methylthiopyrimidine derivative to the corresponding sulfoxide followed by displacement with the desired amine. While these schemes herein are presented, for instance, with an optionally substituted piperidine moiety for the resultant R2 position, or a 4-fluoro phenyl for R4, any suitable R2 moiety or R4 moiety may be added in this manner if it can be prepared on the primary amine. Similarly, any suitable R4 can be added via the isonitrile route. The compounds of Formula (II), in Scheme I, may be prepared by the methods of Van Leusen et al., supra. For example a compound of the Formula (II) may be prepared by dehydrating a compound of the Formula (IV)-Scheme I, wherein Ar, R4 and p are as defined herein. Suitable dehydrating agents include phosphorus oxychloride, oxalyl chloride, thionyl chloride, phosgene, or tosyl chloride in the presence of a suitable base such as triethylamine or dusopropylethylamine, or similar bases, etc. such as pyridine. Suitable solvents are dimethoxy ether, tetrahydrofuran, or halogenated solvents, preferably THF. The reaction is most efficent when the reaction temperatures are kept between -10°C and 0°C. At lower temperatures incomplete reaction occurs and at higher temperatures, the solution turns dark and the product yield drops. The compounds of formula (IV)-Scheme I may be prepared by reacting a compound of the formula (V)-Scheme I, R4CHO where R4 is as defined herein, with ArS(0)pH and formamide with or without water removal, preferably under dehydrating conditions, at ambient or elevated temperature e.g. 30° to 150°, conveniently at reflux, optionally in the presence of an acid catalyst. Alternatively trimethysilylchloride can be used in place of the acid catalyst. Examples of acid catalysts include camphor- 10-sulphonic acid, formic acid, p-toluenesulphonic acid, hydrogen chloride or sulphuric acid. An optimal method of making an isonitrile of Formula (II) is illustrated below, in Scheme XI. 70% yield 4 SCHEME XI The conversion of the substituted aldehyde to the tosylbenzyl formamide may be accomplished by heating the aldehyde, 1 -Scheme XI, with an acid, such as p-toluene- sulfonic acid, formic acid or camphorsulfonic acid; with formamide and p-toluene-sulfinic acid [under reaction conditions of about 60°C for about 24 hours]. Preferably, no solvent is used. The reaction, may give poor yields (< 30%) when solvents, such as DMF, DMSO, toluene, acetonitrile, or excess formamide are used. Temperatures less than 60°C are generally poor at producing the desired product, and temperatures in excess of 60°C may produce a product which decomposes, or obtain a benzylic bis -formamide, 2-Scheme XI. In Example 23 (a), described in WO 95/02591 , Adams et al., synthesizes 4-Fluorophenyl- tosylmethylformamide, a compound of Formula (IV) -Scheme I, wherein p = 2. This procedure differs from that presently described herein by the following conditions, using the sodium salt of toluene sulfinic acid, neat which process results in uneven heating, lower yields and lower reproduceability then the present invention, as described herein which uses sulfinic acid and allows for use of non-aqueous conditions. Conditions for making α-(p-Toluenesulfonyl)-4-fluorobenzylisonitrileas described in Example 23 (b), of WO 95/02591, Adams et al., used as a solvent MeCl to extract the product and DME as solvent. The present invention improves upon this process by utiizing less expensive solvents, such as THF and EtOAc to extract. Further higher yields are obtained by recrystalizing with an alcohol, such as 1 -propanol, although other alcohols, such as methanol, ethanol and butanols are acceptable. Previously, the compound was partially purifed using chromatography techniques, and hazardous solvents for additional purifications. Another embodiment of the present invention is the synthesis of the tosyl benzyl formamide compound, achieved by reacting the bisformamide intermediate, 2-Scheme XI, with p-toluenesulfinic acid. In this preferred route, preparation of the bis-formamide from the aldehyde is accomplished by heating the aldehyde with formamide, in a suitable solvent with acid catalysis. Suitable solvents are toluene, acetonitrile, DMF, and DMSO or mixtures thereof. Acid catalysts, are those well known in the art, and include but are not limited to hydrogen chloride, p-toluenesulfonic acid, camphorsulfonic acid, and other anhydrous acids. The reaction can be conducted at temperatures ranging from about 25°C to 110°C, preferably about 50°C, suitably for about 4 to about 5 hours, longer reaction times are also acceptable. Product decomposition and lower yields may be observed at higher temperatures (>70°C) at prolonged reactions times. Complete conversion of the product generally requires water removal from the reaction mixture. Preferred conditions for converting a bis-formamide derivative to the tosyl benzyl formamide are accomplished by heating the bisformamide in a suitable solvent with an acid catalyst and p-toluenesulfinic acid. Solvents for use in this reaction include but are not limited to toluene, and acetonitrile or mixtures thereof. Additional mixtures of these solvents with DMF, or DMSO may also be used but may result in lower yields. Temperatures may range from about 30°C to about 100°C. Temperatures lower than 40°C and higher than 60°C are not preferred as the yield and rate decreases. Preferably the range is from about 40 to 60°C, most preferably about 50°C. The optimal time is about 4 to 5 hours, although it may be longer. Preferably, acids used include but are not limited to, toluenesulfonic acid, camphorsulfonic acid, and hydrogen chloride and other anhydrous acids. Most preferably the bisformamide is heated in toluene: acetonitrile in a 1: 1 ratio, with p-toluenesulfinic acid and hydrogen chloride. Another embodiment of the present invention is the preferred synthetic route for synthesis of the tosylbenzyl formamide compound which is accomplished using a one-pot procedure. This process first converts the aldehyde to the bis-formamide derivative and subsequently reacts the bis-formamide derivative with toluenesulfinic acid. This procedure combines the optimized conditions into a single, efficient process. High yields, >90% of the aryl benzylformamide may be obtained in such a manner. Preferred reaction conditions employ a catalyst, such as trimethylsilyl chloride (TMSC1), in a preferred solvent, toluene:acetonitrile, preferably in a 1 : 1 ratio. A reagent, such as TMSC1 , is preferred which reacts with water produced therein and at the same time produces hydrogen chloride to catalyze the reaction. Also preferred is use of hydrogen chloride and p-toluenesulfonic acid. Therefore, three suitable reaction conditions for use herein include 1 ) use of a dehydrating agent which also provides hydrogen chloride, such as TMSC1; or by 2) use of a suitable dehydrating agent and a suitable source of acid source, such as but not limited to, camphorsulfonic acid, hydrogen chloride or toluenesulfonic acid; and 3) alternative dehydrating conditions, such as the azeotropic removal of water, and using an acid catalyst and p-toluene sulfinic acid. Compounds of the formula (II) where p is 2 may also be prepared by reacting in the presence of a strong base a compound of the formula (VI) -Scheme I, R4CH2NC with a compound of the formula (Vϋ)-Scheme I, ArSO2Li wherein R4 and Ar are as defined herein and Li is a leaving group such as halo, e.g. fluoro. Suitable strong bases include, but are not limited to, alkyl lithiums such as butyl lithium or lithium diisopropylamide (van Leusen et al.. Tetrahedron Letters. No. 23, 2367-68 (1972)). The compounds of formula (VΙ)-Scheme I may be prepared by reacting a compound of the formula (VILI)-Scheme I, R4CH2NH2 with an alkyl formate (e.g. ethylformate) to yield an intermediate amide which can be converted to the desired isonitrile by reacting with well known dehydrating agent, such as but not limited to oxalyl chloride, phosphorus oxychloride or tosyl chloride in the presence of a suitable base such as triethylamine. Alternatively a compound of the formula (VIII) - Scheme I may be converted to a compound of the formula (VI)- Scheme I by reaction with chloroform and sodium hydroxide in aqueous dichloromethane under phase transfer catalysis. The compounds of the formula (III) - Scheme I may be prepared by reacting a compound of the formula R CHO with a primary amine R2NH2. The amino compounds of the formula (VIII) - Scheme I are known or can be prepared from the corresponding alcohols, oximes or amides using standard functional group interconversions. Conditions' a) I. NH 2 OH«HCI, Na 2 CO a , H 2 0 , n. Ranβy Ni, H 2 , b) 2-amιnopyπ ιdιnyl- -carboxald yde, CH 2 CI 2 . c) 4-fluorophθnyl-tolythιomθthyιsocyanιdθ, TBD, CH 2 CI 2 , d) i HCl, H 2 θ, π Na 2 C0 3 , H 2 0, e) NH 2 OH«HCI, Na 2 C0 3 , H 2 0 , f NaCNBH 3 , MeOH, g) KNCO, DMF, H 2 0, HOAC SCHEME XII Cycloalkanones such as 1 -Scheme XII (available from Aldrich Chemical Co., Milwaukee, Wi) may be converted to cycloalkylamines such as 2-Scheme XII by conventional procedures for reductive amination such as oxime formation with hydroxylamine in H 2 O followed by reduction of the oxime to the amine by standard conditions such as catalytic hydrogenation with Raney Ni in an H 2 atmosphere. The resulting cycloalkylamines such as 2-Scheme XII may be reacted with aryl aldehydes such as 2-aminopyrimidinyl-4-carboxaldhyde in non-hydroxylic organic solvents to form imines such as 3-Scheme XII. Depending on the degree of activation of the aldehydes towards imine formation, catalytic acid (such as toluenesulfonic acid) and dehydrating conditions (such as azeotropic removal of water in refluxing benzene) may or may not be needed. Imines such as 3-Scheme XII may be converted to 1 ,4 diaryl imidazoles alkylated with cycloalkyl groups by reaction with isonitriles such as 4-fluorophenyl- tolylthiomethylisocyanide in the presence of a base such as l,5,7-triazabicyclo[4.4.0]-dec-5- ene (TBD) in organic solvents such as CH 2 C1 . In this way 3-Scheme XII was converted to 5-Scheme XII. Cycloalkyl ketal substituted imidazoles such as 5-Scheme XII are hydrolyzed with aqueous acids (such as aqueous HCl) followed by neutralization with base (such as aqueous Na 2 CO 3 ) to afford ketones such as 6-Scheme VI. 6-Scheme XII is converted to the oxime 7-Scheme XII with hydroxylamine in H O. 7-Scheme XD is converted to the hydroxylamine 8-Scheme XII by reduction with sodium cyano borohydride in methanol. 8-Scheme X is converted to the hydroxyureas 9-Scheme XII by the procedure of Adams et al (WO 91/14674 published 3 October 1991). 6 10 X = 0/S SCHEME XIII In the above noted Scheme, the alcohol 10-Scheme XIII may be prepared by reducing the ketone of 6-Scheme 13 with a suitable reducing agent, such as NaBH4. MeOH, p-toluene sulfonic acid Scheme XIV This compound, alcohol 10-Scheme Xlfl, and related alcohols can also be prepared eir own right as shown in Scheme XIV above, and in Scheme XV, below. Scheme XV In formula XI below, R] is may be an optionally substituted alkyl, aryl or a heteroaryl group and R2 is either an OH, NH2 or SH, or R* and R2 together can form a C3-7 cycloalkyl ring, such as, for example a pyrrolidine or piperdine ring. Some representative examples of such compounds are illustrated in scheme XVI below. (XI) SCHEME XVI The ketone 1 can be reacted with any organomettalic reagent (RiM) to afford the corresponding alcohol 2 ( wherein R\ can be hydrogen or any optionally susbtituted alkyl aryl, arylalkyl, heteocyclic, heterocyclic alkyl, etc. moiety). The alcohol 2 can be converted to the neopentyl amine 3, by using the classical Ritter reaction well known by those of skill in th art. The amine 3 can be acylated or sulfonylated. The ketone 1 can be can be transformed into an spirooxirane 4 by reagents such as dimethylsulfonium methylide and dimethyl sulfoxonium methylide. The oxirane 4 can be ring opened with a plethora of nucleophiles such as hydroxides, thiolates, amines, organometallic reagents (such as the well known organo-cuprate or organo-aluminum reagents, etc.). SCHEME XVπ The ketone 1 -Scheme XVII may also be subjected to reductive amination by any primary or secondary amines to afford amines 6-Scheme XVIII. RT and R 2 can be any alkyl or aryl group.Ri and R 2 can also be a part of a ring SCHEME XVIII Suitable protecting groups for use with hydroxyl groups and the imidazole nitrogen are well known in the art and described in many references, for instance. Protecting Groups in Organic Synthesis, Greene T W, Wiley-Interscience, New York, 1981. Suitable examples of hydroxyl protecting groups include silyl ethers, such as t-butyldimethyl or t- butyldiphenyl, and alkyl ethers, such as methyl connected by an alkyl chain of variable link, (CRιoR20)n- Suitable examples of imidazole nitrogen protecting groups include tetrahydropyranyl. Pharmaceutically acid addition salts of compounds of Formula (I) may be obtained in known manner, for example by treatment thereof with an appropriate amount of acid in the presence of a suitable solvent. METHODS OF TREATMENT The compounds of Formula (I) or a pharmaceutically acceptable salt thereof can be used in the manufacture of a medicament for the prophylactic or therapeutic treatment of any disease state in a human, or other mammal, which is exacerbated or caused by excessive or unregulated cytokine production by such mammal's cell, such as but not limited to monocytes and/or macrophages. Compounds of Formula (I) are capable of inhibiting proinflammatory cytokines, such as IL-1, IL-6, IL-8 and TNF and are therefore of use in therapy. IL-1, IL-6, IL-8 and TNF affect a wide variety of cells and tissues and these cytokines, as well as other leukocyte-derived cytokines, are important and critical inflammatory mediators of a wide variety of disease states and conditions. The inhibition of these pro-inflammatory cytokines is of benefit in controlling, reducing and alleviating many of these disease states. Compounds of Formula (I) are capable of inhibiting inducible proinflammatory proteins, such as COX-2, also referred to by many other names such as prostaglandin endoperoxide synthase-2 (PGHS-2) and are therefore of use in therapy. These proinflammatory lipid mediators of the cyclooxygenase (CO) pathway are produced by the inducible COX-2 enzyme. Regulation, therefore of COX-2 which is responsible for the these products derived from arachidonic acid, such as prostaglandins affect a wide variety of cells and tissues are important and critical inflammatory mediators of a wide variety of disease states and conditions. Expression of COX-1 is not effected by compounds of Formula (I). This selective inhibition of COX-2 may alleviate or spare ulcerogenic liability associated with inhibition of COX- 1 thereby inhibiting prostoglandins essential for cytoprotective effects. Thus inhibition of these pro-inflammatory mediators is of benefit in controlling, reducing and alleviating many of these disease states. Most notably these inflammatory mediators, in particular prostaglandins, have been implicated in pain, such as in the sensitization of pain receptors, or edema. This aspect of pain management therefore includes treatment of neuromuscular pain, headache, cancer pain, and arthritis pain. Compounds of Formula (I) or a pharmaceutically acceptable salt thereof, are of use in the prophylaxis or therapy in a human, or other mammal, by inhibition of the synthesis of the COX-2 enzyme. Accordingly, the present invention provides a method of inhibiting the synthesis of COX-2 which comprises administering an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof. The present invention also provides for a method of prophylaxis treatment in a human, or other mammal, by inhibition of the synthesis of the COX-2 enzyme. Accordingly, the present invention provides a method of treating a cytokine- mediated disease which comprises administering an effective cytokine-interfering amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof. In particular, compounds of Formula (I) or a pharmaceutically acceptable salt thereof are of use in the prophylaxis or therapy of any disease state in a human, or other mammal, which is exacerbated by or caused by excessive or unregulated LL-1, EL-8 or TNF production by such mammal's cell, such as, but not limited to, monocytes and/or macrophages. Accordingly, in another aspect, this invention relates to a method of inhibiting the production of IL- 1 in a mammal in need thereof which comprises administering to said mammal an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof. There are many disease states in which excessive or unregulated LL- 1 production is implicated in exacerbating and/or causing the disease. These include rheumatoid arthritis, osteoarthritis, stroke, endotoxemia and/or toxic shock syndrome, other acute or chronic inflammatory disease states such as the inflammatory reaction induced by endotoxin or inflammatory bowel disease, tuberculosis, atherosclerosis, muscle degeneration, multiple sclerosis, cachexia, bone resorption, psoriatic arthritis, Reiter's syndrome, rheumatoid arthritis, gout, traumatic arthritis, rubella arthritis and acute synovitis. Recent evidence also links IL-1 activity to diabetes, pancreatic β cells and Alzheimer's disease. In a further aspect, this invention relates to a method of inhibiting the production of TNF in a mammal in need thereof which comprises administering to said mammal an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Excessive or unregulated TNF production has been implicated in mediating or exacerbating a number of diseases including rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions, sepsis, septic shock, endotoxic shock, gram negative sepsis, toxic shock syndrome, adult respiratory distress syndrome, stroke, cerebral malaria, chronic pulmonary inflammatory disease, silicosis, pulmonary sarcoisosis, bone resorption diseases, such as osteoporosis, reperfusion injury, graft vs. host reaction, allograft rejections, fever and myalgias due to infection, such as influenza, cachexia secondary to infection or malignancy, cachexia secondary to acquired immune deficiency syndrome (AIDS), AIDS, ARC (AIDS related complex), keloid formation, scar tissue formation, Crohn's disease, ulcerative colitis and pyresis. Compounds of Formula (I) are also useful in the treatment of viral infections, where such viruses are sensitive to upregulation by TNF or will elicit TNF production in vivo. The viruses contemplated for treatment herein are those that produce TNF as a result of infection, or those which are sensitive to inhibition, such as by decreased replication, directly or indirectly, by the TNF inhibiting-compounds of Formula (1). Such viruses include, but are not limited to HIV-1, HIV-2 and HIV-3, Cytomegalovirus (CMV), Influenza, adenovirus and the Heφes group of viruses, such as but not limited to, Heφes Zoster and Heφes Simplex. Accordingly, in a further aspect, this invention relates to a method of treating a mammal afflicted with a human immunodeficiency virus (HLV) which comprises administering to such mammal an effective TNF inhibiting amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Compounds of Formula (I) may also be used in association with the veterinary treatment of mammals, other than in humans, in need of inhibition of TNF production. TNF mediated diseases for treatment, therapeutically or prophylactically, in animals include disease states such as those noted above, but in particular viral infections. Examples of such viruses include, but are not limited to, lentivirus infections such as, equine infectious anaemia virus, caprine arthritis virus, visna virus, or maedi virus or retrovirus infections, such as but not limited to feline immunodeficiency virus (FIV), bovine immunodeficiency virus, or canine immunodeficiency virus or other retroviral infections. The compounds of Formula (I) may also be used topically in the treatment or prophylaxis of topical disease states mediated by or exacerbated by excessive cytokine production, such as by LL-1 or TNF respectively, such as inflamed joints, eczema, psoriasis and other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation. Compounds of Formula (I) have also been shown to inhibit the production of LL-8 (Interleukin-8, NAP). Accordingly, in a further aspect, this invention relates to a method of inhibiting the production of IL-8 in a mammal in need thereof which comprises administering to said mammal an effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof. There are many disease states in which excessive or unregulated LL-8 production is implicated in exacerbating and/or causing the disease. These diseases are characterized by massive neutrophil infiltration such as, psoriasis, inflammatory bowel disease, asthma, cardiac and renal reperfusion injury, adult respiratory distress syndrome, thrombosis and glomerulonephritis. All of these diseases are associated with increased LL-8 production which is responsible for the chemotaxis of neutrophils into the inflammatory site. In contrast to other inflammatory cytokines (IL-1, TNF, and IL-6), IL-8 has the unique property of promoting neutrophil chemotaxis and activation. Therefore, the inhibition of IL-8 production would lead to a direct reduction in the neutrophil infiltration. The compounds of Formula (I) are administered in an amount sufficient to inhibit cytokine, in particular IL-1, IL-6, IL-8 or TNF, production such that it is regulated down to normal levels, or in some case to subnormal levels, so as to ameliorate or prevent the disease state. Abnormal levels of IL-1, IL-6, LL-8 or TNF, for instance in the context of the present invention, constitute: (i) levels of free (not cell bound) LL-1, LL-6, IL-8 or TNF greater than or equal to 1 picogram per ml; (ii) any cell associated IL-1, IL-6, LL-8 or TNF; or (iii) the presence of LL-1, LL-6, LL-8 or TNF mRNA above basal levels in cells or tissues in which IL-1, LL-6, LL-8 or TNF, respectively, is produced. The discovery that the compounds of Formula (I) are inhibitors of cytokines, specifically LL-1, LL-6, LL-8 and TNF is based upon the effects of the compounds of Formulas (I) on the production of the IL-1, IL-8 and TNF in in vitro assays which are described herein. As used herein, the term "inhibiting the production of IL-1 (IL-6, IL-8 or TNF)" refers to: a) a decrease of excessive in vivo levels of the cytokine (IL- 1 , IL-6, LL-8 or TNF) in a human to normal or sub-normal levels by inhibition of the in vivo release of the cytokine by all cells, including but not limited to monocytes or macrophages; b) a down regulation, at the genomic level, of excessive in vivo levels of the cytokine (IL-1, IL-6, IL-8 or TNF) in a human to normal or sub-normal levels; c) a down regulation, by inhibition of the direct synthesis of the cytokine (LL-1, LL-6, LL-8 or TNF) as a postranslational event; or d) a down regulation, at the translational level, of excessive in vivo levels of the cytokine (LL-1, LL-6, LL-8 or TNF) in a human to normal or sub-normal levels. As used herein, the term "TNF mediated disease or disease state" refers to any and all disease states in which TNF plays a role, either by production of TNF itself, or by TNF causing another monokine to be released, such as but not limited to LL-1, LL-6 or LL-8. A disease state in which, for instance, LL-1 is a major component, and whose production or action, is exacerbated or secreted in response to TNF, would therefore be considered a disease stated mediated by TNF. As used herein, the term "cytokine" refers to any secreted polypeptide that affects the functions of cells and is a molecule which modulates interactions between cells in the immune, inflammatory or hematopoietic response. A cytokine includes, but is not limited to, monokines and lymphokines, regardless of which cells produce them. For instance, a monokine is generally referred to as being produced and secreted by a mononuclear cell, such as a macrophage and/or monocyte. Many other cells however also produce monokines, such as natural killer cells, fibroblasts, basophils, neutrophils, endothelial cells, brain astrocytes, bone marrow stromal cells, epideral keratinocytes and B-lymphocytes. Lymphokines are generally referred to as being produced by lymphocyte cells. Examples of cytokines include, but are not limited to, Interleukin- 1 (IL-1), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Tumor Necrosis Factor-alpha (TNF-α) and Tumor Necrosis Factor beta (TNF-β). As used herein, the term "cytokine interfering" or "cytokine suppressive amount" refers to an effective amount of a compound of Formula (I) which will cause a decrease in the in vivo levels of the cytokine to normal or sub-normal levels, when given to a patient for the prophylaxis or treatment of a disease state which is exacerbated by, or caused by, excessive or unregulated cytokine production. As used herein, the cytokine referred to in the phrase "inhibition of a cytokine, for use in the treatment of a HIV-infected human" is a cytokine which is implicated in (a) the initiation and or maintenance of T cell activation and/or activated T cell-mediated HIV gene expression and or replication and/or (b) any cytokine-mediated disease associated problem such as cachexia or muscle degeneration. As TNF-β (also known as lymphotoxin) has close structural homology with TNF-α (also known as cachectin) and since each induces similar biologic responses and binds to the same cellular receptor, both TNF-α and TNF-β are inhibited by the compounds of the present invention and thus are herein referred to collectively as "TNF" unless specifically delineated otherwise. A new member of the MAP kinase family, alternatively termed CSBP, p38, or RK, has been identified independently by several laboratories recently. Activation of this novel protein kinase via dual phosphorylation has been observed in different cell systems upon stimulation by a wide spectrum of stimuli, such as physicochemical stress and treatment with lipopolysaccharide or proinflammatory cytokines such as interleukin- 1 and tumor necrosis factor. The cytokine biosynthesis inhibitors, of the present invention, compounds of Formula (I), have been determined to be potent and selective inhibitors of CSBP/p38/RK kinase activity. These inhibitors are of aid in determining the signalling pathways involvement in inflammatory responses. In particular, for the first time a definitive signal transduction pathway can be prescribed to the action of lipopolysaccharide in cytokine production in macrophages. The cytokine inhibitors were subsequently tested in a number of animal models for anti-inflammatory activity. Model systems were chosen that were relatively insensitive to cyclooxygenase inhibitors in order to reveal the unique activities of cytokine suppressive agents. The inhibitors exhibited significant activity in many such in vivo studies. Most notable are its effectiveness in the collagen-induced arthritis model and inhibition of TNF production in the endotoxic shock model. In the latter study, the reduction in plasma level of TNF correlated with survival and protection from endotoxic shock related mortality. Also of great importance are the compounds effectiveness in inhibiting bone resoφtion in a rat fetal long bone organ culture system. Griswold et al., (1988) Arthritis Rheum. 31: 1406- 1412; Badger, et al., (1989) Circ. Shock 27, 51-61; Votta et al., (1994)zn vitro. Bone 15, 533-538; Lee et al., (1993). B Ann. N. Y. Acad. Sci. 696, 149-170. In order to use a compound of Formula (I) or a pharmaceutically acceptable salt thereof in therapy, it will normally be Formulated into a pharmaceutical composition in accordance with standard pharmaceutical practice. This invention, therefore, also relates to a pharmaceutical composition comprising an effective, non-toxic amount of a compound of Formula (I) and a pharmaceutically acceptable carrier or diluent. Compounds of Formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions incoφorating such may conveniently be administered by any of the routes conventionally used for drug administration, for instance, orally, topically, parenterally or by inhalation. The compounds of Formula (I) may be administered in conventional dosage forms prepared by combining a compound of Formula (I) with standard pharmaceutical carriers according to conventional procedures. The compounds of Formula (I) may also be administered in conventional dosages in combination with a known, second therapeutically active compound. These procedures may involve mixing, granulating and compressing or dissolving the ingredients as appropriate to the desired preparation. It will be appreciated that the form and character of the pharmaceutically acceptable character or diluent is dictated by the amount of active ingredient with which it is to be combined, the route of administration and other well-known variables. The carrier(s) must be "acceptable" in the sense of being compatible with the other ingredients of the Formulation and not deleterious to the recipient thereof. The pharmaceutical carrier employed may be, for example, either a solid or liquid. Exemplary of solid carriers are lactose, terra alba, sucrose, talc, gelatin, agar, pectin, acacia, magnesium stearate, stearic acid and the like. Exemplary of liquid carriers are syrup, peanut oil, olive oil, water and the like. Similarly, the carrier or diluent may include time delay material well known to the art, such as glyceryl mono-stearate or glyceryl distearate alone or with a wax. A wide variety of pharmaceutical forms can be employed. Thus, if a solid carrier is used, the preparation can be tableted, placed in a hard gelatin capsule in powder or pellet form or in the form of a troche or lozenge. The amount of solid carrier will vary widely but preferably will be from about 25 mg. to about lg. When a liquid carrier is used, the preparation will be in the form of a syrup, emulsion, soft gelatin capsule, sterile injectable liquid such as an ampule or nonaqueous liquid suspension. Compounds of Formula (I) may be administered topically, that is by non-systemic administration. This includes the application of a compound of Formula (I) externally to the epidermis or the buccal cavity and the instillation of such a compound into the ear, eye and nose, such that the compound does not significantly enter the blood stream. In contrast, systemic administration refers to oral, intravenous, intraperitoneal and intramuscular administration. Formulations suitable for topical administration include liquid or semi-liquid preparations suitable for penetration through the skin to the site of inflammation such as liniments, lotions, creams, ointments or pastes, and drops suitable for administration to the eye, ear or nose. The active ingredient may comprise, for topical administration, from 0.001% to 10% w/w, for instance from 1% to 2% by weight of the Formulation. It may however comprise as much as 10% w/w but preferably will comprise less than 5% w/w, more preferably from 0.1% to 1% w/w of the Formulation. Lotions according to the present invention include those suitable for application to the skin or eye. An eye lotion may comprise a sterile aqueous solution optionally containing a bactericide and may be prepared by methods similar to those for the preparation of drops. Lotions or liniments for application to the skin may also include an agent to hasten drying and to cool the skin, such as an alcohol or acetone, and/or a moisturizer such as glycerol or an oil such as castor oil or arachis oil. Creams, ointments or pastes according to the present invention are semi-solid Formulations of the active ingredient for external application. They may be made by mixing the active ingredient in finely-divided or powdered form, alone or in solution or suspension in an aqueous or non-aqueous fluid, with the aid of suitable machinery, with a greasy or non-greasy base. The base may comprise hydrocarbons such as hard, soft or liquid paraffin, glycerol, beeswax, a metallic soap; a mucilage; an oil of natural origin such as almond, corn, arachis, castor or olive oil; wool fat or its derivatives or a fatty acid such as steric or oleic acid together with an alcohol such as propylene glycol or a macrogel. The Formulation may incorporate any suitable surface active agent such as an anionic, cationic or non-ionic surfactant such as a sorbitan ester or a polyoxyethylene derivative thereof. Suspending agents such as natural gums, cellulose derivatives or inorganic materials such as silicaceous silicas, and other ingredients such as lanolin, may also be included. Drops according to the present invention may comprise sterile aqueous or oily solutions or suspensions and may be prepared by dissolving the active ingredient in a suitable aqueous solution of a bactericidal and/or fungicidal agent and/or any other suitable preservative, and preferably including a surface active agent. The resulting solution may then be clarified by filtration, transferred to a suitable container which is then sealed and sterilized by autoclaving or maintaining at 98-100° C. for half an hour. Alternatively, the solution may be sterilized by filtration and transferred to the container by an aseptic technique. Examples of bactericidal and fungicidal agents suitable for inclusion in the drops are phenylmercuric nitrate or acetate (0.002%), benzalkonium chloride (0.01%) and chlorhexidine acetate (0.01%). Suitable solvents for the preparation of an oily solution include glycerol, diluted alcohol and propylene glycol. Compounds of formula (I) may be administered parenterally, that is by intravenous, intramuscular, subcutaneous intranasal, intrarectal, intravaginal or intraperitoneal administration. The subcutaneous and intramuscular forms of parenteral administration are generally preferred. Appropriate dosage forms for such administration may be prepared by conventional techniques. Compounds of Formula (I) may also be administered by inhalation, that is by intranasal and oral inhalation administration. Appropriate dosage forms for such administration, such as an aerosol Formulation or a metered dose inhaler, may be prepared by conventional techniques. For all methods of use disclosed herein for the compounds of Formula (I), the daily oral dosage regimen will preferably be from about 0.1 to about 80 mg/kg of total body weight, preferably from about 0.2 to 30 mg kg, more preferably from about 0.5 mg to 15mg. The daily parenteral dosage regimen about 0.1 to about 80 mg/kg of total body weight, preferably from about 0.2 to about 30 mg kg, and more preferably from about 0.5 mg to 15mg/kg. The daily topical dosage regimen will preferably be from 0.1 mg to 150 mg, administered one to four, preferably two or three times daily. The daily inhalation dosage regimen will preferably be from about 0.01 mg/kg to about 1 mg/kg per day. It will also be recognized by one of skill in the art that the optimal quantity and spacing of individual dosages of a compound of Formula (I) or a pharmaceutically acceptable salt thereof will be determined by the nature and extent of the condition being treated, the form, route and site of administration, and the particular patient being treated, and that such optimums can be determined by conventional techniques. It will also be appreciated by one of skill in the art that the optimal course of treatment, i.e., the number of doses of a compound of Formula (I) or a pharmaceutically acceptable salt thereof given per day for a defined number of days, can be ascertained by those skilled in the art using conventional course of treatment determination tests. The invention will now be described by reference to the following biological examples which are merely illustrative and are not to be construed as a limitation of the scope of the present invention. BIOLOGICAL EXAMPLES The cytokine-inhibiting effects of compounds of the present invention were determined by the following in vitro assays: Interleukin - 1 (IL-1) Human peripheral blood monocytes are isolated and purified from either fresh blood preparations from volunteer donors, or from blood bank buffy coats, according to the procedure of Colotta et al, J Immunol, 132, 936 (1984). These monocytes (lxlo are plated in 24-well plates at a concentration of 1-2 million ml per well. The cells are allowed to adhere for 2 hours, after which time non-adherent cells are removed by gentle washing. Test compounds are then added to the cells for about 1 hour before the addition of lipopolysaccharide (50 ng/ml), and the cultures are incubated at 37°C for an additional 24 hours. At the end of this period, culture supernatants are removed and clarified of cells and all debris. Culture supernatants are then immediately assayed for IL-1 biological activity, either by the method of Simon et al., J. Immunol. Methods, 84, 85, (1985) (based on ability of IL-1 to stimulate a Interleukin 2 producing cell line (EL-4) to secrete IL-2, in concert with A23187 ionophore) or the method of Lee et al. , J. ImmunoTherapy, 6 ( 1 ), 1 - 12 ( 1990) (ELISA assay). Tumour Necrosis Factor (TNF): Human peripheral blood monocytes are isolated and purified from either blood bank buffy coats or plateletpheresis residues, according to the procedure of Colotta, R. et al, J Immunol, 132(2), 936 (1984). The monocytes are plated at a density of lxlO 6 cells/ml medium well in 24-well multi-dishes. The cells are allowed to adhere for 1 hour after which time the supernatant is aspirated and fresh medium (1ml, RPMI- 1640, Whitaker Biomedical Products, Whitaker, CA) containing 1 % fetal calf serum plus penicillin and streptomycin (10 units/ml) added. The cells are incubated for 45 minutes in the presence or absence of a test compound at InM-lOmM dose ranges (compounds are solubilized in dimethyl sulfoxide/ethanol, such that the final solvent concentration in the culture medium is 0.5% dimethyl sulfoxide/0.5% ethanol). Bacterial lipopoly-saccharide (E. coli 055:B5 [LPS] from Sigma Chemicals Co.) is then added (100 ng/ml in 10 ml phosphate buffered saline) and cultures incubated for 16-18 hours at 37°C in a 5% CO2 incubator. At the end of the incubation period, culture supernatants are removed from the cells, centrifuged at 3000 φra to remove cell debris. The supernatant is then assayed for TNF activity using either a radio-immuno or an ΕLISA assay, as described in WO 92/10190 and by Becker et al, J Immunol, 1991, 147, 4307. IL-1 and TNF inhibitory activity does not seem to correlate with the property of the compounds of Formula (I) in mediating arachidonic acid metabolism inhibition. Further the ability to inhibit production of prostaglandin and/or leukotriene synthesis, by nonsteroidal anti-inflammatory drugs with potent cyclooxygenase and/or lipoxygenase inhibitory activity does not mean that the compound will necessarily also inhibit TNF or LL- 1 production, at non-toxic doses. In vivo TNF assay: While the above indicated assay in an in vitro assay, the compounds of Formula (I) may also be tested in an in vivo system such as described in : (1) "Differentiation In Vivo of Classical Non-Steroidal Antiinflammatory Drugs from Cytokine Suppressive Antiinflammatory Drugs and Other Pharmacological Classes Using Mouse Tumour Necrosis Factor Alpha Production", Griswold et al. Drugs Under Εxp. and Clinical Res..XLX (6), 243-248 (1993); or in (2) Boehm, et al, 1 -substituted 4-aryl-5-pyridinylimidazoles - a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency. Journal Of Medicinal Chemistry 39, 3929-3937 (1996) whose disclosures are incoφorated by reference herein in their entirety. Interleukin -8 (IL-8 ): Primary human umbilical cord endothelial cells (HUVΕC) (Cell Systems, Kirland, Wa) are maintained in culture medium supplemented with 15% fetal bovine serum and 1% CS-HBGF consisting of aFGF and heparin. The cells are then diluted 20-fold before being plated (250μl) into gelating coated 96-well plates. Prior to use, culture medium are replaced with fresh medium (200μl). Buffer or test compound (25μl, at concentrations between 1 and lOμM) is then added to each well in quadruplicate wells and the plates incubated for 6h in a humidified incubator at 37°C in an atmosphere of 5% CO2- At the end of the incubation period, supernatant is removed and assayed for IL-8 concentration using an IL-8 ELISA kit obtained from R&D Systems (Minneapolis, MN). All data is presented as mean value (ng/ml) of multiple samples based on the standard curve. ICso's where appropriate are generated by non-linear regression analysis. C tokine Specific Binding Protein Assay A radiocompetitive binding assay was developed to provide a highly reproducible primary screen for structure-activity studies. This assay provides many advantages over the conventional bioassays which utilize freshly isolated human monocytes as a source of cytokines and ELISA assays to quantify them. Besides being a much more facile assay, the binding assay has been extensively validated to highly correlate with the results of the bioassay. A specific and reproducible cytokine inhibitor binding assay was developed using soluble cystosolic fraction from THP.1 cells and a radiolabeled compound. Patent Application USSN 08/123175 Lee et al., filed September 1993, USSN; Lee et al., PCT 94/10529 filed 16 September 1994 and Lee et al., Nature 300, n(72), 739-746 (Dec. 1994) whose disclosures are incoφorated by reference herein in its entirety describes the above noted method for screening drugs to identify compounds which interact with and bind to the cytokine specific binding protein (hereinafter CSBP). However, for puφoses herein the binding protein may be in isolated form in solution, or in immobilized form, or may be genetically engineered to be expressed on the surface of recombinant host cells such as in phage display system or as fusion proteins. Alternatively, whole cells or cytosolic fractions comprising the CSBP may be employed in the screening protocol. Regardless of the form of the binding protein, a plurality of compounds are contacted with the binding protein under conditions sufficient to form a compound/ binding protein complex and compound capable of forming, enhancing or interfering with said complexes are detected. Representative final compounds of Formula (I), Examples 5 to 11 have all demonstrated positive inhibitory activity in this binding assay. CSBP KINASE ASSAY: This assay measures the CSBP-catalyzed transfer of 32p f rθ m [a-32p]ATP to threonine residue in an epidermal growth factor receptor (EGFR)-derived peptide (T669) with the following sequence: KRELVEPL7PSGEAPNQALLR (residues 661-681). (See Gallagher et al., "Regulation of Stress Induced Cytokine Production by Pyridinyl Imidazoles: Inhibition of CSPB Kinase", BioOrganic & Medicinal Chemistry, to be published 1996). Kinase reactions (total volume 30 ul) contain: 25 mM Hepes buffer, pH 7.5; 10 mM MgCl2; 170 uM ATPO); 10 uM Na ortho vanadate; 0.4 mM T669 peptide; and 20-80 ng of yeast-expressed purified CSBP2 (see Lee et al., Nature 300, n(72), 739-746 (Dec. 1994)). Compounds (5 ul from [6X] stock( 2 )) are pre-incubated with the enzyme and peptide for 20 min on ice prior to starting the reactions with 32P/MgATP. Reactions are incubated at 30 °C for 10 min and stopped by adding 10 ul of 0.3 M phosphoric acid. 32P-labeled peptide is separated on phosphocellulose (Wattman, p81) filters by spotting 30 ul reaction mixture. Filters are washed 3 times with 75 mM phosphoric acid followed by 2 washes with H2O, and counted for 32P. (!) The Km of CSBP for ATP was determined to be 170 uM. Therefore, compounds screened at the Km value of ATP. (2) Compounds are usually dissolved in DMSO and are diluted in 25 mM Hepes buffer to get final concentration of DMSO of 0.17% . Prostoglandin endoperoxide synthase-2 (PGHS-2) assay: The following assay describes a method for determining the inhibitory effects of compounds of Formula (I) on human PGHS-2 protein expression in LPS stimulated human monocytes. Method: Human peripheral blood monocytes were isolated from buffy coats by centrifugation through Ficoll and Percoll gradients. Cells were seeded at 2 X 10^/well in 24 well plates and allowed to adhere for 1 hour in RPMI supplemented with 1 % human AB serum, 20mM L-glutamine, Penicillin-Streptomycin and lOmM HEPES. Compounds were added at various concentrations and incubated at 37°C for 10 minutes. LPS was added at 50 ng/well (to induce enzyme expression) and incubated overnight at 37°C. The supernatant was removed and cells washed once in cold PBS. The cells were lysed in lOOμl of cold lysis buffer(50mM Tris/HCl pH 7.5, 150mM NaCl, 1% NP40, 0.5% sodium deoxycholate, 0.1% SDS, 300ug/ml DNAse, 0.1% TRITON X-100, ImM PMSF, ImM leupeptin, ImM pepstatin). The lysate was centrifuged ( 10,000 X g for 10 min. at 4°C) to remove debris and the soluble fraction was subjected to SDS PAGE, analysis (12% gel). Protein separated on the gel were transferred onto nitrocellulose membrane by electrophoretic means for 2 hours at 60 volts. The membrane was pretreated for one hour in PBS/0.1% Tween 20 with 5% non-fat dry milk. After washing 3 times in PBS/Tween buffer, the membrane was incubated with a 1:2000 dilution of a monospecific antiserum to PGHS-2 or a 1 : 1000 dilution of an antiserum to PGHs- 1 in PBS/Tween with 1 % BS A for one hour with continuous shaking. The membrane was washed 3X in PBS Tween and then incubated with a 1:3000 dilution of horseradish peroxidase conjugated donkey antiserum to rabbit Ig (Amersham) in PBS Tween with 1% BSA for one hour with continuous shaking. The membrane was then washed 3X in PBS Tween and the ECL immunodetection system (Amersham) was used to detect the level of expression of prostaglandin endoperoxide synthases-2. RESULTS: The following compounds were tested and found to be active (inhibited LPS induced PGHS-2 protein expression in rank order potency similar to that for inhibiting cytokine production as noted in assays indicated): 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo[2, l-b]thiazole and Dexamethasone Several compounds were tested and found to be inactive (up to lOuM): 2-(4-Methylsulfinylphenyl)-3-(4-pyridyl)-6,7-dihydro-(5H)-pyrrolo[l,2- a]imidazole,rolipram, phenidone and NDGA. None of the compounds tested was found to inhibit PGHS-1 or cPLA2 protein levels in similar experiments. SYNTHETIC EXAMPLES The invention will now be described by reference to the following examples which are merely illustrative and are not to be construed as a limitation of the scope of the present invention. All temperatures are given in degrees centigrade, all solvents are highest available purity and all reactions run under anhydrous conditions in an argon atmosphere unless otherwise indicated. In the Examples, all temperatures are in degrees Centigrade (°C). Mass spectra were performed upon a VG Zab mass spectrometer using fast atom bombardment, unless otherwise indicated. 1 H-NMR (hereinafter "NMR") spectra were recorded at 250 MHz using a Bruker AM 250 or Am 400 spectrometer. Multiplicities indicated are: s=singlet, d=doublet, t=triplet, q=quartet, m=multiplet and br indicates a broad signal. Sat. indicates a saturated solution, eq indicates the proportion of a molar equivalent of reagent relative to the principal reactant. Flash chromatography is run over Merck Silica gel 60 (230 - 400 mesh). Example 1 l-f4-Oxocvclohexyl ) -4-f4-fluorophenylι-5-f ( 2-methoxy)pyrimidin-4-yllimidazole a) 4-Fluorophenyl-tolylsulfonomethylformarnide To a suspension of p-toluenesulfinic acid sodium salt (30 g) in H 2 O (100 mL) was added methyl t-butyl ether (50 mL) followed by dropwise addition of cone. HCl (15 mL). After stirring 5 min., the organic phase was removed and the aqueous phase was extracted with methyl t-butyl ether. The organic phase was dried (Na 2 SO 4 ) and concentrated to near dryness. Hexane was added and the free acid was filtered. The p-toluenesulfinic acid (22 g, 140.6 mmol), p-fluorobenzaldehyde (22 mL, 206 mmol), formamide (20 mL, 503 mmol) and camphor sulphonic acid (4 g, 17.3 mmol) were combined and stirred at 60°C 18 h. The resulting solid was broken up and stirred with a mixture of MeOH (35 mL) and hexane (82 mL) then filtered. The solid was resuspended in MeOH hexane (1:3, 200 mL) and stirred vigorously to break up remaining chunks. Filtration afforded the title compound (27 g, 62 % yield). 1H NMR (400 MHz, CDC1 3 ): 6 8.13 (s, IH), 7.71 (d, 2H), 7.43 (dd, 2H), 7.32 (d, 2H), 7.08 (t, 2H), 6.34 (d, IH), 2.45 (s, 3H). b) 4-Fluorophenyl-tolylsulfonomethylisocyanide The compound in the previous step (2.0 lg, 6.25 mmol) in ethylene glycol dimethylether (DME) (32 mL) was cooled to -10°C. POCl 3 (1.52 mL, 16.3 mmol) was added followed by the dropwise addition of triethylamine (4.6 mL, 32.6 mmol) in DME (3mL) keeping the internal temperature below -5°C. The mixture was gradually warmed over 1 h., quenched in H O and extracted with EtOAc. The organic phase was washed with sat. aqueous NaHCO 3 , dried (Na 2 SO 4 ), and concentrated. The resulting residue was triturated with petroleum ether and filtered to afford the title compound (1.7 g, 90% yield). 1H NMR (CDC1 3 ): 6 7.63 (d, 2H), 7.33 (m, 4H), 7.10 (t, 2H), 5.60 (s, IH), 2.50 (s, 3H) c) 2-N-Methylthiopyrimidine-4-carboxaldehvde dimethyl acetal Pyruvic aldehyde dimethyl acetal (60 mL, 459 mmol) and N,N-dimethyl formamide dimethyl acetal (60 mL, 459 mmol) were stirred together at 100°C for 18 h. The mixture was cooled. Methanol (300 mL), thiourea (69.6 g) and sodium methoxide (231 mL, 25 wt% in MeOH) were added to the above mixture and stirred at 70°C for 2 h. After cooling, iodomethane (144 mL) was added dropwise and the mixture was stirred 3 h. at room temp. After diluting with EtOAc and H2O, the organic phase was separated, dried (Na2SO4),and concentrated to yield the title compound as a brown oil (75.5 g, 82% yield). H NMR (CDCI 3 ): δ 8.17 (d, IH), 6.77 (d, IH), 5.15 (s, IH), 3.40 (s, 6H). d) 2-Methylthiopyrimidine-4-carboxaldehyde A mixture of the compound from the previous step (10.04 g, 55 mmol) in 3N HCl (45 mL) was stirred at 47°C for 24 h. After cooling EtOAc was added followed by the addition of solid NaHCO 3 . The aqueous phase was extracted with EtOAc (4 x 100 mL). The organic phases were combined, dried (Na 2 SO 4 ), and concentrated to afford the title compound as a yellow foam.Η NMR (CDC1 3 ): δ 9.95 (s, IH), 8.77 (d, IH), 7.43 (d, IH), 2.63 (s, 3H). e) 1 - Amino-4-( 1.3-dioxycyclopentyl cyclohexane To a mixture of 1 ,4-cyclohexanedione monoethylene ketal (27.6 g, 177 mmol) and hydroxylamine hydrochloride (49.2 g, 708 mmol) in H 2 O (250 mL) was added portionwise Na 2 CO 3 (49.2 g, 547 mmol). After stirring 1 h, the mixture was extracted with EtOAc. The organic phase was dried (Na 2 SO 4 ) and concentrated affording 4-(l,3-dioxycyclopentyl)- cyclohexanone oxime (27.5 g, 90% yield). The oxime (27.5 g, 161 mmol), Raney Ni (ca 13.5 mL as a suspension in EtOH) and EtOH (200 mL) were combined and shaken at 50 psi H 2 for 4 h. The catalyst was filtered off and the filtrate was concentrated to afford the title compound as a colorless oil (23.6 g, 93% yield). 1H NMR (CDC1 3 ): δ 2.64 (m, IH), 1.75 - 1.25 (m, 12 H). f) 2-Methylthiopyrimidine-4-carboxaldehyde(4-ethylene ketal cyclohexyDimine A mixture of 2-methylthiopyrimidine-4-carboxaldehyde (9.5 g, 6.9 mmol) prepared in example 1(d) and l-amino-4-(l,3-dioxycyclopentyl)cyclohexane (10.8 g, 6.9 mmol) from the previous step were stirred in DMF (150 mL) 18 h. The title compound was used without any purification. Η NMR (CDC1 3 ): δ 8.51 (d, IH), 8,21 (s, IH), 7.53 (d, IH), 3.93, (s, 4H), 3.40 (m, IH), 2.55 (s, 3H), 1.94 - 1.70 (m, 6H), 1.61 (m, 2H). g) l-(4-Ethylene ketal cyclohexyl)imidazole-4-(4-fluorophenylV 5-[(2- methylthio)pyrimidin-4-yl] imidazole To the crude product from the previous example in DMF cooled to 0°C was added 4-fluorophenyl-tolylsulfonomethylisocyanide prepared in example 1 (b) (26 g, 90 mmol) and K 2 CO 3 (15.7 g, 113.6 mmol). The mixture was stirred at 0°C for 3 h. then gradually warmed to room temp, and stirred for 18 h. EtOAc was added and the mixture was filtered washing the solid with EtOAc. H 2 O was added to the filtrate and the organic phase was separated, dried (Na 2 SO 4 ), and concentrated. The mixture was evaporated to near dryness and filtered washing with 1: 1 EtOAc/hexane to afford the title compound as pale yellow crystals. 1H NMR (CDC1 3 ): δ 8.33 (d, IH), 7.81 (s, IH), 7.43 (q, 2H), 7.12 (t, 2H), 6.78 (d, IH), 4.74 (m, IH), 4.00 (s, 4H), 2.59 (s, 3H), 2.18 (dd, 2H), 2.04 (dq, 2H), 1.89 (dd, 2H), 1.70 (dt, 2H). h) l-(4-Ethylene ketal cvclohexyD l-4-(4-fluorophenvn-5-I('2- methylsulfoxy)pyrimidin-4-yllimidazole To a solution of the compound from the previous step (0.20 g, .48 mmol) in THF (2 mL) and MeOH (1 mL) at 0°C was added oxone monopersulfate (0.36 g, .56 mmol) dissolved in H 2 O (2 mL). The mixture was stirred for .5 h. then poured into 10% NaOH and extracted with EtOAc. The organic phase was dried (Na 2 SO ) and concentrated. The resulting residue was triturated with Et 2 O and filtered affording the title compound as a white solid (0.089 g, 45% yield) Η NMR (CDC1 3 ): δ 8.36 (d, IH), 7.82 (s, IH), 7.42 (q, 2H), 7.02 (t, 2H), 6.79 (d, IH), 4.80 (m, IH), 4.00 (s, 3H), 2.20 (m, 2H), 2.06 (m, 3H), 1.89 (m, 2H), 1.70 (m, 5H). i) 1 - ( 4-Ethylene ketal cvclohexyl -f4-fluorophenylV5-IQ-methoxy pyrimidin-4- yl]imidazole Sodium methoxide (5.17 mL, 22.6 mmol, 25 wt% in MeOH) was added to dry THF (33 mL) followed by the compound from the previous example (5 g, 11.3 mmol). The mixture was stirred at room temp 2 h. then layered with EtOAc and diluted with H2O. The organic phase was dried (Na2SO4) and concentrated, the residue was purified by flash chromatography (silica gel, 5% MeOH/CH2Cl2). The resulting residue was triturated with EtOAc/hexane( 1 : 1) to give the title compound as a white solid (3.57 g, 77% yield). -1H NMR (CDCI3): δ 8.34 (d, IH), 7.81 (s, IH), 7.40 (q, 2H), 7.00 (t, 2H), 6.78 (d, IH), 4.79 (m, IH), 4.05 (s, 3H), 3.99 (s, 4H), 2.17 (m, 2H), 2.05 (s, 2H), 1.90 (m, 2H), 1.69 (dt, 2H). j) l-f4-Oxocyclohexyl)-4-(4-fluorophenyl -5-r(2-methoxy pyrimidin-4-yllimidazole A mixture of the compound from the previous step (10.73 g, 26.23 mmol) in 3N HCl (150 mL) was stirred 36 h. then neutralized with saturated aqueous Na 2 CO 3 and filtered. The solid was washed with water and the aqueous mixture was extracted with EtOAc. The organic phase was dried (Na 2 SO ) and concentrated giving the title compound as white crystals, mp 212 - 214°C. Example 2 trαn -l-(4-HydroxycyclohexylV4-(4-fluorophenyl)-5-[(2-methoxy pyrimidin-4- vnimidazole To a solution of the compound in example l(j) (0.099 g, .27 mmol) in MeOH/THF (1 mL, 1:1) was added NaBH 4 solution [1 mL, IM sin. made by combining .10 g, Na BH , MeOH (2.5 mL), and 25% NaOMe in MeOH (0.2 mL)]. After stirring 10 min., the mixture was quenched with saturated Na 2 CO 3 and the solvent was evaporated. The residue was recrystalized from MeOH H 2 O to afford the title compound as white needles (0.063 g, 63% yield), mp 188 - 190°C. Example 3 1-f4-OxocvclohexylV4-(4-fluorophenyiy5-r(2-isopropoxy pyrimidin-4-yl] imidazole a) 1 -(4-Ethylene ketal cyclohexylV4-(4-fluorophenyl>5-r(2-isopropoxy pyrimidin-4- yllimidazole A mixture of sodium metal (0.161 g, .7 mmol) and isopropanol (30 mL) was stirred with gentle heat until the sodium metal dissolved. Added was a suspension of l-(4-ethylene ketal cyclohexyl)-4-(4-fluorophenyl)-5-[(2-methylsulfoxy)pyrimidin-4-yl]imidazole prepared in example 1(h) (0.3 g, .7 mmol) in isopropanol (10 mL) and the mixture was stirred 2 h. at 90°C. The mixture was cooled and diluted with H 2 O and extracted with EtOAc. The organic phase was dried (Na 2 SO 4 ) and concentrated. Crystalization from EtOH/H 2 O afforded the title compound (0.15 g, 49% yield). Η NMR (CDC1 3 ): δ 8.35 (d, IH), 7.81 (s, lh), 7.43 (q, 2H), 7.01 (t, 2H), 6.73 (d, IH), 5.30 (m, IH), 4.77 (m, IH), 3.99 (s, 4H), 2.16 (m, 2H), 2.05 (dq, 2H), 1.90 (d, 2H), 1.68 (dt, 2H), 1.45 (d, 6H). b) l-(4-Oxocyclohexy -4-f4-fluorophenylV5-r(2-isopropoxy ' )pyrimidin-4-yllimidazole Following the procedure of example l(j) except using the compound from the previous step afforded the title compound as white crystals, mp 161 - 163°C. Example 4 l-(4-Oxocvclohexyl -(4-fluorophenylV5-[2-(2-hydroxyethoxy)pyrimidin-4-yllimidazole a) l-(4-Ethylene ketal cvclohexyn-4-(4-fluorophenviy5-r2-(2- hydroxyethoxylpyrimidin-4-yllimidazole Following the procedure of example 3(a) except using ethylene glycol and stirring at room temp, for 3 days afforded the title compound as a white solid. Η NMR (CDC1 3 ): δ 8.36 (d, IH), 7.86 (s, IH), 7.41 (q, 2H), 7.02 (t, 2H), 6.80 (d, IH), 4.77 (m, IH), 4.54 (t, 2H), 4.01 (m, 2H), 3.98 (s, 4H), 2.19 (m, 2H), 2.07 (m, 2H), 1.90 (d, 2H), 1.70 (dt, 2H). b) l-(4-OxocycIohexyI)-4-(4-fluorophenylV5-r2-(2-hydroxyethoxy')pyrimidin-4- vnimidazole Following the procedure of example l(j) except using the compound from the previous step and triturating the residue with EtOAc/hexane afforded the title compound as a white solid. mp 203 - 205°C. Example 5 l-(4-Hydroxycyclohexyl ) -4-(4-fluorophenylV5-r2-(2-hydroxyethoxy')pyrimidin-4- yll imidazole Following the procedure of example 2 except using the compound in example 4(b) and triturating the residue with EtOAc afforded the title compound, mp 191 - 193°C. Example 6 l-(4-Oxocyclohexyl ) -4-(4-fluorophenylV5-(r2-(2-tert-butylamino ethoxy1pyrimidin-4- yDimidazole a) 1 -(4-Ethylene ketal cvclohexylV4-(4-fluorophenyl)-5-([2-(2-tert- butyIamino)ethoxylpyrimidin-4-vDimidazole To a suspension of NaH (0.11 g, 2.92 mmol, 60% susp. in mineral oil) in dry THF (5 mL) was added 2-(N-tert-butylamino)ethanol (0.34 g, 2.92 mmol). When gas evolution ceased, l-(4-ethylene ketal cyclohexyl)-4-(4-fluorophenyl)-5-[(2-methylsulfoxy)pyrimidin- 4-yl]imidazole prepared in example 1(h) (1.46 mmol) suspended in dry THF (8 mL) was added and the mixture was stirred for .5 h. then diluted with H 2 O and extracted with EtOAc. The organic phase was dried (Na 2 SO 4 ) and concentrated. The residue was triturated with EtOAc/hexane to afford the title compound as a white solid. 1H NMR (CDC1 3 ): δ 8.35 (d, IH), 7.81 (s, IH), 7.41 (q,2H), 7.00 (t, 2H), 6.79 (d, IH), 4.75 (m, IH), 4.50 (t, 2H), 4.00 (s, 4H), 3.01 (t, 2H), 2.15 (m, 2H), 2.03 (dd, 2H), 1.88 (m, 2H), 1.69 (m, 2H), 1.16 (s, 9H). b) l-(4-OxocyclohexyD-4- ( 4-fluorophenylι-5-(r2-(2-tert-butylamino)ethoxy1- pyrimidin-4-vnimidazole Following the procedure of example l(j) except using the compound in the previous step and recrystalizing with EtOAc hexane afforded the title compound as white needles, mp 235 - 237°C. Example 7 l-(4-HydroxycyclohexylV4-(4-fluorophenylι-5-([2-f2-tgrt-butylar no)ethoxylpyrirnidin-4- yPimidazole Following the procedure of example 2 except using the compound in example 6(b) afforded the title compound as a white solid, mp 165 - 170°C. Example 8 l-(4-HydroxycyclohexylV4-(4-fluorophenylV5-f(2-isopropoxy pyrimidin-4-yllimidazole Following the procedure of example 2 except using the compound in example 3(b) afforded the title compound. mp 208 - 2H°C. Example 9 trα/ϊ -l-(4-Hydroxycyclohexyl)-4-(4-fluorophenyπ-5-(r2-(2-methoxy ethoxy]pyrimidin-4- yniπύdazole a) l-(4-Ethylene ketal cvclohexyn-4-( ' 4-fluorophenvn-5-(T2-r2- methoxy)ethoxy1pyrimidin-4-yDimidazole Following the procedure of example 6(a) except using methoxyethanol afforded the title compound as a solid. 1H NMR (CDCI3): δ 8.35 (d, lh), 7.81 (s, IH), 7.41 (q, 2H), 7.02 (t, 2H), 6.78 (d, IH), 4.77 (m, IH), 4.55 (t, 2H), 4.00 (s, 4H), 3.81 (t, 2H), 3.45 (s, 3H), 2.18 (m, 2H), 2.04 (dq, 2H), 1.88 (m, 2H), 1.70 (m, 2H). b) l-(4-OxocyclohexyD-4-(4-fluorophenylV5-([2-(2-methoxy)ethoxy1pyrimidin-4- yllimidazole Following the procedure of example l(j) except using the compound from the previous step afforded the title compound as a white solid. ^H NMR (CDCI3): δ 8.35 (d, IH), 7.78 (s, IH), 7.42 (q, 2H), 7.03 (t, 2H), 6.79 (d, IH), 5.30 (m, IH), 4.59 (t, 2H), 3.81 (t, 2H), 3.45 (s, 3H), 2.55 (m, 6H), 2.20 (m, 2H). c) tran5-l-(4-HydrocycyclohexylV4-(4-fluorophenyl)-5-(r2-(2- methoxy ethoxy1pyrimidin-4-yl midazole Following the procedure of example 2 except using the compound from the previous step afforded the title compound, mp 185 - 186°C. Example 10 l-r(4-Hvdroxy)-4-hydroxymethylcyclohexyl1-4-(4-fluorophenyl)-5-f(2- methoxy)pyrimidine-4-yllimidazole a) l-f4-Oxiranylcyclohexyl -4-(4-fluorophenylV5-[(2-methoxy')pyrimidin-4- yllimidazole Added to a mixture of sodium hydride (.05 g, .88 mmol) in DMSO (1 mL) was trimethyl sulfoxonium iodide (.29 g, 1.3 mmol). After stirring the resultant mixture 1.5 h. (when gas evolution ceases), l-(4-oxocyclohexyl)-4-(4-fluorophenyl)-5-[(2- methoxy)pyrimidin-4-yl] imidazole from example l(j) (.322 g, .88 mmol) suspended in dry THF (4 mL) was added and the mixture was stirred 4h. The mixture was poured into H2O and extracted with EtOAc. The organic phase was dried (Na2SO4) and concentrated. The resulting residue was suspended in EtOAc/hexane (1:1) and filtered. The solid was purified by flash chromatography (silica gel 2% MeOH/CH2Cl2) to afford the title compound as white crystals (.18 g, 53% yield) H NMR (CDCI3): δ 8.35 (d, IH), 7.85 (s, IH), 7.43 (q, 2H), 7.02 (t, 2H), 6.80 (d, IH), 4.86 (m, IH), 4.09 (s, 3H), 2.76 (s, 2H), 2.26 (m, 2H), 2.20 - 2.02 (m, 4H), 1.43 (d, 2H). b) l-r(4-Hvdroxy)-4-hydroxymethylcyclohexyl1-4-(4-fluorophenyl)-5-r(2- methoxy py rimidin-4-y 11 imidazole The compound from the previous step (.178 g, .47 mmol) was stirred in 88% formic acid (6 mL) 1 h. The mixture was concentrated and the residue was dissolved in methanol (5 mL). Thiethylamine (.26 mL, 1.88 mmol) was added and the mixture was stirred 18 h. and was concentrated. The residue was purified by flash chromatography (silica gel, 5% - 10% MeOH CH2θ2). The product was triturated with EtOAc/hexane (1:1) and recrystalized from EtOH/H2θ to afford the title compound as a white solid (.065 g, 35% yield), mp 225 - 226°C. Example 11 l-r4-Oxocvclohexyl ') -4- ( 4-fluorophenyl ' )-5-rr2-fN.N-dimethylamino)ethoxy1pyrimidin-4- yttimidazole a) 1-(4-Ethylene ketal cvclohexyn-4-(4-fluorophenylV5-(r2-rN.N- dimethylarmnotethoxylpyrimidin-4-yl midazole Following the procedure of example 6(a) except using 2-dimethylamino ethanol afforded the title compound as a white solid. H NMR (CDCI3): δ 8.35 (d, IH), 7.82 (s, IH), 7.42 (q, 2H), 7.01 (t, 2H), 6.77 (d, IH), 4.77 (m, IH), 4.50 (t, 2H), 4.00 (s, 4H), 2.80 (t, 2H), 2.37 (s, 6H), 2.17 (d, 2H), 2.05 (dq, 2H), 1.89 (m, 2H), 1.67 (dt, 2H). b) l-(4-Oxocvclohexyl)-4-(4-fluorophenylV5-(T2-fN.N- dimethylaminotethoxy]pyrimidin-4-yl)imidazole Following the procedure of example l(j) except using the compound from the previous step afforded the title compound as white needles, mp 84 - 86°C. All publications, including but not limited to patents and patent applications, cited in this specification are herein incoφorated by reference as if each individual publication were specifically and individually indicated to be incoφorated by reference herein as though fully set forth. The above description fully discloses the invention including preferred embodiments thereof. Modifications and improvements of the embodiments specifically disclosed herein are within the scope of the following claims. Without further elaboration, it is believed that one skilled in the are can, using the preceding description, utilize the present invention to its fullest extent. Therefore the Examples herein are to be construed as merely illustrative and not a limitation of the scope of the present invention in any way. The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows.

Claims: What is Claimed Is: 1. A compound of the Formula wherein Rl is 4-pyridyl, pyrimidinyl, quinolyl, isoquinolinyl, quinazolin-4-yl, 1-imidazolyl or 1-benzimidazolyl, which ring is substituted with a substituted Ci-4 alkoxy or a substituted Ci-4 alkylthio group, and is additionally optionally substituted independently by Ci-4 alkyl, halogen, hydroxyl, Ci-4 alkoxy, Ci-4 alkylthio, Ci-4 alkylsulfmyl, CH2OR12, amino, mono and di- Ci-6 alkyl substituted amino, N(Rιo)C(O)Rc or an N-heterocyclyl ring which ring has from 5 to 7 members and optionally contains an additional heteroatom selected from oxygen, sulfur or NR15; R4 is phenyl, naphth-1-yl or naphth-2-yl, or a heteroaryl, which is optionally substituted by one or two substituents, each of which is independently selected, and which, for a 4- phenyl, 4-naphth-l-yl, 5-naphth-2-yl or 6-naphth-2-yl substituent, is halogen, cyano, nitro, -C(Z)NR7Rπ, -C(Z)ORi6, -(CRio 2θ)vCORi2, -SR5, -SOR5, -OR12, halo- substituted-Ci-4 alkyl, Ci-4 alkyl, -ZC(Z)Ri2, -NRιoC(Z)Ri6, or -(CRiθR2θ)vNRlθR20 and which, for other positions of substitution, is halogen, cyano, -C(Z)NRi3Rl4. -C(Z)OR3, -(CRiθR20)m"COR3, -S(O) m R3, -OR3, halo- substituted-Ci-4 alkyl, -Ci-4 alkyl, -(CRιoR2θ)m"NRlθC(Z)R3, -NRιoS(O) m 'R8, -NRioS(O) m -NR 7 Rl7v -ZC(Z)R3 or -(CRioR20)m"NRl3Rl4; v is 0, or an integer having a value of 1 or 2; m is 0, or the integer 1 or 2; m' is an integer having a value of 1 or 2, m" is 0, or an integer having a value of 1 to 5; R c is hydrogen, C\. alkyl, C3.7 cycloalkyl, aryl, arylCi-4 alkyl, heteroaryl, heteroarylCi-4alkyl, heterocyclyl, or heterocyclylC 1 _4alkyl -4 alkyl R2 is an optionally substituted C3-7 cycloalkyl, or C3.7cycloalkylC1.10 alkyl; R3 is heterocyclyl, heterocyclylC i- 10 alkyl or R%; R5 is hydrogen, Ci-4 alkyl, C2-4 alkenyl, C2-4 alkynyl or NR7R17, excluding the moieties -SR5 being -SNR7R17 and -SOR5 being -SOH; R7 and R17 is each independently selected from hydrogen or C1-4 alkyl or R7 and R17 together with the nitrogen to which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR 15; R8 is Ci-io alkyl, halo-substituted Ci-io alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-.7 cycloalkyl, C5.7 cycloalkenyl, aryl, arylCi-io alkyl, heteroaryl, heteroarylCi-io alkyl, (CRioR20)nORn, (CRloR20)nS(O) m Rl8, (CRioR2θ)nNHS(O) Rl8, (CRiθR2θ)n Rl3Rl4; wherein the aryl, arylalkyl, heteroaryl, heteroaryl alkyl may be optionally substituted; n is an integer having a value of 1 to 10; Ro is hydrogen, -C(Z)Rι 1 or optionally substituted Cι_ιo alkyl, S(O)2Rl8. optionally substituted aryl or optionally substituted aryl-Ci-4 alkyl; RlO and R20 is each independently selected from hydrogen or C 1.4 alkyl; Rl 1 is hydrogen, or Ri8; R12 is hydrogen or Ri6; Rj3 and R14 is each independently selected from hydrogen or optionally substituted Cι_4 alkyl, optionally substituted aryl or optionally substituted aryI-Ci-4 alkyl, or together with the nitrogen which they are attached form a heterocyclic ring of 5 to 7 members which ring optionally contains an additional heteroatom selected from oxygen, sulfur or NR9 ; Rl5 is hydrogen, Ci-4 alkyl or C(Z)-Ci-4 alkyl; R 16 is C 1-4 alkyl, halo-substituted-C 1.4 alkyl, or C3-7 cycloalkyl; Rl8 is Cι_ιo alkyl, C3-7 cycloalkyl, heterocyclyl, aryl, arylCi-io alkyl, heterocyclyl, heterocyclyl-Ci-ioalkyl, heteroaryl or heteroarylalkyl; and Z is oxygen or sulfur; or a pharmaceutically acceptable salt thereof. 2. The compound according to Claim 1 wherein Ri is a substituted 4-pyridyl or 4- pyrimidinyl. 3. The compound according to Claim 2 wherein the substituent is a substituted Cι_4 alkoxy. 4. The compound according to Claim 2 wherein R4 is an optionally substituted phenyl. 5. The compound according to Claim 4 wherein the phenyl is substituted one or more times independently by halogen,-SR5, -S(O)R5, -OR12, halo-substituted-Ci-4 alkyl, or Ci-4 alkyl. 6. The compound according to Claim 1 wherein R2 is selected from optionally substituted C4 to Cόcycloalkyl, or optionally substituted C4 or Cό cycloalkylCi-4 alkyl. 7. The compound according to Claim 6 wherein the cycloalkyl ring may substituted one to three times independently by halogen; hydroxy; Ci-io alkoxy; S(O) m Ci-ioalkyl, wherein m is 0, 1, or 2; amino; cyano, nitro; NR7R17 group; Ci-io alkyl; substituted alkyl wherein the substituents are selected from halogen, hydroxy, nitro, cyano, NR7R17, S(O)m Cι_4 alkyl, C(O)ORπ; - O-(CH2) s O-, and s is 1 to 3; -C(O)H; =O; =N-ORι 1; -N(Rιo)-OH; - N(OR D )-C(O)-Rd; optionally substituted aryl; or optionally substituted arylalkyl; N(Rιo)C(O)Xι; C(O)ORι 1; optionally substituted alkylene; or optionally substituted C 1 - 1 oalky nyl ; wherein Rb is hydrogen, a pharmaceutically acceptable cation, aroyl or a Cj-io alkanoyl group; Rd is NR21R22' alkyl \. halosubstituted alkyl \. ; hydroxy substituted alkyl 1-6; alkenyl 2-6; aryl or heteroaryl optionally substituted by halogen, alkyl 1-6, halosubstituted alkyl 1-6, hydroxyl, or alkoxy 1-6; R21 is hydrogen or alkyl 1 - ; and R22 is hydrogen, alkyl \. , aryl, benzyl, heteroaryl, alkyl substituted by halogen or hydroxyl, or phenyl substituted by a member selected from the group consisting of halo, cyano, alkyl ι_ 2, alkoxy ι_ , halosubstituted alkyl 1 -6, alkylthio, alkylsulphonyl, or alkylsulfmyl; or R21 and R22 may together with the nitrogen to which they are attached form a ring having 5 to 7 members, which members may be optionally replaced by a heteroatom selected from oxygen, sulfur or nitrogen; and Xl is C1-4 alkyl, aryl or arylCi-4alkyl; N(Rιo)C(O) aryl. 8. The compound according to Claim 7 wherein the optional substitutents are hydroxy, aryl, arylalkyl, alkyl, alkynyl, NR7R17, NR7R17 Ci-6 alkyl, =O, =NORι 1, -NH(OH), -N(OH)-C(O)-NH2, cyanoalkyl, nitroalkyl, or -O-(CH2)2θ-. 9. The compound according to Claim 1 which is: 5-[2-(2-Hydroxyethoxy)pyrimidin-4-yl]-4-(4-fluorophenyl)- 1 -(4-oxocyclohexyl)- imidazole; 5-[2-(2-Hydroxyethoxy)]pyrimidin-4-yl)-4-(4-fluorophenyl)- 1 -(4-hydroxy cyclohexyl)- imidazole; 5-[2-(2-tert-Butylamino)ethoxypyrimidin-4-yl]-4-(4-fluorophenyl)-l-(4-oxocyclohexyl)- imidazole; 5-[2-(2-tert-Butylamino)ethoxypyrimidin-4-yl]-4-(4- fluorophenyl)- 1 -(4-hydroxy- cyclohexyl)imidazole; or a pharmaceutically acceptable salt thereof. 10. A pharmaceutical composition comprising a compound according to Claim 1 and a pharmaceutically acceptable carrier or diluent. 11. A method of treating a CSBP/RK/p38 kinase mediated disease, in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound of Formula (I) according to any of Claims 1 to 9. 12. The method according to claim 11 wherein the mammal is afflicted with a CSBP/RK p38 kinase mediated disease which is psoriatic arthritis, Reiter's syndrome, rheumatoid arthritis, gout, traumatic arthritis, rubella arthritis and acute synovitis, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic condition, sepsis, septic shock, endotoxic shock, gram negative sepsis, toxic shock syndrome, Alzheimer's disease, stroke, neurotrauma, asthma, adult respiratory distress syndrome, cerebral malaria, chronic pulmonary inflammatory disease, silicosis, pulmonary sarcososis, bone resoφtion disease, osteoporosis, restenosis, cardiac and renal reperfusion injury, thrombosis, glomerulonephritis, diabetes, graft vs. host reaction, allograft rejection, inflammatory bowel disease, Crohn's disease, ulcerative colitis, multiple sclerosis, muscle degeneration, eczema, contact dermititis, psoriasis, sunburn, or conjunctivitis. 13. The method according to Claim 12 wherein the disease state is mediated by IL-1 , IL- 6, LL-8, or TNF. 14. The method according to Claim 12 wherein the cytokine mediated disease state is asthma, osteoporosis or arthritis. 15. A method of treating inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound of Formula (I) according to any of Claims 1 to 9. 16. A method of treating osteoporosis in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound of Formula (I) according to any of Claims 1 to 9. 17. A method of inhibiting the synthesis of prostaglandin endoperoxide synthase-2 (PGHS-2) in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound of Formula (I) according to Claim 1. 18. The method according to Claim 17 wherein inhibition of PGHS-2 is used in the prophylaxis or therapeutic treatment of edema, fever, algesia, neuromuscular pain, headache, cancer pain, or arthritic pain. 19. A process for preparing a compound of Formula (I) as defined in Claim 1 which comprises reacting a compound of the Formula (II) : with a compound of the Formula (III) wherein p is 0 or 2; and a base strong enough to deprotonate the isonitrile moiety of Formula (II); and R\, R2 and R4 are as defined in Claim 1 or are precursors of the groups Rj, R2 and R4 and Ar is an optionally substituted phenyl group, and thereafter if necessary, converting a precursor of Ri , R2 and R4 to a group Rl , R2 and R4. 20. The process according to Claim 19 wherein the reaction, when p=0, utilizes TBD as a base. 21. The process according to Claim 19 wherein the reaction, when p=2, the base is an amine, a carbonates, a hydride, or an alkyl or aryl lithium reagent. 22. The process according to Claim 19 wherein the imine of Formula (III), is isolated prior to reaction with Formula (II). 23. The process according to Claim 19 wherein the imine of Formula (III), is formed in situ prior to reaction with Formula (II). 24. The process according to Claim 23 wherein the imine is formed in situ by reacting an aldehyde of the formula RiCHO, wherein Ri is as defined for Formula (I), with a primary amine of the formula R2NH2, wherein R2 is as defined for Formula (I). 25. The process according to Claim 23 wherein formation of the imine in situ utilizes dehydrating conditions. 26. The process according to Claim 25 wherein the solvent is N,N-dimethyl-formamide (DMF), halogenated solvents, tetrahydrofuran (THF), dimethylsulfoxide (DMSO), alcohols, benzene, or toluene, or DME. 27. The process according to Claim 19 wherein the aldehyde RjCHO is a pyrimidine aldehyde of the formula: CHO X wherein X is NHRa and Xi is defined as the optional substituent group(s) on the Rl moiety in Formula (I) according to Claim 1 , to yield a compound of Formula (I) or a pharmaceutically acceptable salt thereof. 28. The process according to Claim 19 wherein the primary amine R2NH2 is a C3-7 cycloalkyl amine, C3-7 cycloalkyl Ci-ioalkyl amine, all of which may be optionally substituted. 29. The process according to Claim 28 wherein R2 moiety is 4-hydroxycyclohexyl, 4- hydroxycyclohexyl, 4-ketocyclohexyl, 4-oxiranylcyclohexyl, 4-methyl-4-hydroxy cyclohexyl, 4-isopropyl-4-hydroxy cyclohexyl, 4-pyrrolinindyl-cyclohexyl, 4-methyl-4- aminocyclohexyl, 4-methyl-4-acetamidocyclohexyl, 4-phenyl-4-hydroxy cyclohexyl, 4- benzyl-4-hydroxy cyclohexyl, l-propenyl-4-hydroxy, 4-hydroxy-4-a ino-cyclohexyl, 4- aminomethyl-4-hydroxy cyclohexyl or 4-(l,3-dioxycyclopentyl) cyclohexyl. 30. The method according to Claim 19 wherein the compound is: 5-[2-(2-Hydroxyethoxy)pyrimidin-4-yl]-4-(4-fluorophenyl)-l-(4-oxocyclohexyl)- imidazole; 5-[2-(2-Hydroxyethoxy)]pyrimidin-4-yl)-4-(4-fluorophenyl)- 1 -(4-hydroxy cyclohexyl)- imidazole; 5-[2-(2-tert-Butylamino)ethoxypyrimidin-4-yl]-4-(4-fluorophenyl)-l-(4-oxocyclohexyl)- imidazole; 5-[2-(2-tert-Butylaιrjino)ethoxypyrimidin-4-yl]-4-(4-fluorophenyl)-l-(4-hydroxy- cyclohexyl)imidazole; or a pharmaceutically acceptable salt thereof.

Inventors: ADAMS JERRY L, GARIGIPATI RAVI S, ADAMS, JERRY, L., GARIGIPATI, RAVI, S.
Applicants: ADAMS JERRY L, GARIGIPATI RAVI S, SMITHKLINE BEECHAM CORP, ADAMS, JERRY, L., GARIGIPATI, RAVI, S., SMITHKLINE BEECHAM CORPORATION
Application year: 1997
Main classification: A61K31
IPC codes: A61K31, A61P11, A61P17, A61P19, A61P29, A61P43, C07D403