BENZOPYRANOPYRROLE AND BENZOPYRANOPYRIDINE ALPHA-1 ADRENERGIC COMPOUNDS

Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.

Description: Benzopyranopyrrole and Benzopyranopyridine AIpha-1 Adrenergic Compounds This application is a continuation-in -part application of U.S. Patent Application Serial No. 08/761,423 which was filed on December 6, 1996. 1. Technical Field The present invention relates to novel organic compounds and compositions which are alpha- 1 (α-1) adrenoreceptor antagonists, processes for making such compounds, synthetic intermediates employed in these processes, and a method for inhibiting alpha- 1 adrenoreceptors and treating benign prostatic hyperplasia (BPH), also called benign prostatic hypertrophy, or other urological diseases such as bladder outlet obstruction and neurogenic bladder, or gynecological syndromes such as dysmenorrhea. 2. Background of the Invention Adrenergic neurons play a major role in the innervation of heart, blood vessel and smooth muscle tissue. Compounds capable of interacting with adrenoreceptor sites within adrenergic nerves can initiate a variety of physiological responses, including vasoconstriction, vasodilation, and increased or decreased heart rate (chronotropic), contractility (inotropic) and metabolic activity. In the past, various adrenergic compounds have been employed to affect these and other physiological responses. However, many adrenergic compounds do not possess significant selectivity to enable desirable interactions with adrenergic adrenoreceptor sites. That is, these adrenergic compounds do not demonstrate a high degree of specificity for differing adrenoreceptor types within adrenergic neurons in order to obtain a desired physiological response separate from other possible, and perhaps less desirable, responses of the system. Benign prostatic hyperplasia (BPH) is a condition which develops in middle-aged and elderly males and refers to the benign overgrowth of the stromal and epithelial elements of the prostate associated with aging. Symptoms of BPH include increased frequency of urination, nocturia, a weak urine stream and hesitancy or delay in starting the urine flow. Chronic consequences of BPH can include hypertrophy of bladder smooth muscle, a decompensated bladder and an increased incidence of urinary tract infection. Typically, BPH begins at an age in the mid-fifties and is the most common cause of urinary tract problems of men of this age. BPH is apparently rare in men prior to age 40, but at age 60, approximately 50% of men have histological evidence of BPH. The prevalence of BPH continues to increase with age until, at age 80, approximately 80% of men have pathological evidence of BPH. Although prostatic hyperplasia is a common finding in older men, the presence of urinary symptoms is the essential feature that distinguishes simple anatomic enlargement of the prostate from prostatism, which is the clinical syndrome whereby the patient experiences significant obstruction of urinary flow. It is not uncommon in older men to have a palpably enlarged prostate without showing the symptoms of prostatism. From the patient's perspective, however, the incidence and progression of urinary symptoms are more important than the mere presence of an enlarged prostate. The discovery in the 1970's (M. Caine, et al, Brit. J. Urol.. 47: 193-202 (1975)) of large numbers of alpha-adrenergic adrenoreceptors in the smooth muscle of the prostatic capsule and bladder neck led to the conclusion that there is both a static and a dynamic component to bladder outlet obstruction associated with BPH. The static component derives from the progressive hyperplasia of the prostate with aging, leading to urethral narrowing which causes symptoms of urinary obstruction. Superimposed on this essentially mechanical problem is the variable degree of smooth muscle contraction controlled by the sympatheic nervous system and which is affected by factors such as stress, cold and sympathomimetic drugs. It is this dynamic component which explains the often rapid fluctuations in symptoms observed in patients with prostatism. The currently most effective treatment for BPH is the surgical procedure of transurethral resection of the prostate (TURP) Since it removes the obstructing tissue (C. Chappie, Br. Med. Journal 304: 1198-1199 (1992)) it is a treatment which is directed to the static and dynamic components of BPH. However, this surgical treatment is associated with rates of mortality (1%) and adverse event (incontinence 2-4%, infection 5-10%, and impotence 5-10%). A non- invasive alternative treatment would thus be highly desirable. The incidental clinical observation that urinary incontinence developed in women during antihypertensive treatment with prazosin (T. Thien, K. P. Delacre, F. M. J. Debruyne, R. A. P. Koene, Br. Med Journal , 622-623 (1978)) and the experimental work of Caine (op cit.) contributed to the recognition of the potential role of selective α-1 adrenoreceptor blockade in diseases of the lower urinary tract. Subsequent studies by several groups have documented the functional role of α-1 adrenoreceptors relative to α-2 adrenoreceptors in the stromal compartment of the prostate, thereby providing a putative molecular basis for the use of specific α-1 adrenoreceptor Mockers in the non-surgical management of BPH (C. R. Chappie, M. L. Aubry, S. James, M. Greengrass, G. Burnstock, R. T. Turner-Warwick, Br. J. Urol. __[: 487- 496 (1989)). Clinical efficacy of α-1 antagonists in BPH has been demonstrated with several non-selective α-1 blockers, including terazosin (Hytrin®), prazosin, and doxazosin. Treatment periods as short as two to four weeks with α-1 adrenoreceptor blockers have shown objective improvements in the mean and maximum urinary flow rates (14-96%) with subjective improvements in patients' symptom scores (R. A. Janknegt, C. R. Chappie, Eur. Urol 24: 319-326 (1993)). Longer term studies with terazosin, indoramin, prazosin, and doxazosin have similarly demonstrated significant improvements in urinary flow rates and subjective symptom scores (R. A. Janknegt, op. cit., H. Lepor, G. Knapp-Maloney, J. Urol. 145: 263A (1991), W. Chow, D. Hahn, D. Sandhu, Br. J. Urol. £5_: 36-38 (1990) and C. R. Chappie, T. J. Christmas, E. J. G. Milroy, Urol. Int. 45.: 47-55 (1990)). However, these agents possess similar dose limiting side effects: hypotension, dizziness, and muscle fatigue. In recent years, it has become clear that BPH and bladder outlet obstruction (BOO) are clinically differentiable, and that the severity of clinical BPH is related to many factors in addition to BOO (Lepor. H.. Alpha Blockade for the Treatment of Benign Prostatic Hypeφlasia. Urol. Clin. N. Amer., 22: 375-386, 1995.). For example, BOO may be related to other urological symptoms such as detrusor instability (Rosier, P.F.W.M., J.J.M.C.H. de la Rosette, H. Wijkstra, Ph.EN. Van Kerrebroeck and F.M.J. Debruyne, Is Detrusor Instability in Elderly Males Related to the Grade of Obstruction?. Νeurourol. Urodynam., 14: 625-633, 1995). In addition, the role of extraprostatic α-1 adrenoreceptors has been postulated as important in the etiology of lower urinary tract symptoms, such that antagonism of these receptors in spinal cord, ganglia, nerve terminals, bladder and bladder neck or the external urethral sphincter could be important in pharmacotherapy of urological conditions such as BOO and neurogenic bladder (Andersson, K-E., Prostatic and extraprostatic α-adrenoceptors- Contributions to the Lower Urinary Tract Symptoms in Benign Prostatic Hypeφlasia. Scand. J. Urol. and Νephrol., 30: 105-111, 1996). The recognition that women possess paraurethral glands which have anatomical, histological and biochemical similarities to the male prostate (Gittes, R.F. and R.M. Nakamura, Female urethral syndrome: A female prostatitis?. Western J. Medicine, 164: 435-438, 1996) suggests a potential role for α-1 adrenoreceptor antagonist pharmacotherapy for amelioration of some symptoms of female urethral syndromes. In addition, α-adrenoreceptors are functionally important to smooth muscle contraction in the uterus (Miller, M.D. and J.M. Marshall, Uterine response to nerve stimulation: relation to hormonal status and catecholamines. Am. J. Physiol., 209: 859-863, 1965) and the modulation of sympathetic responses to catecholamines is enhanced by elevations in the levels of estrogens (Miller and Marshall, Uterine response to nerve stimulation: relation to hormonal status and catecholamines. Am. J. Physiol., 209: 859-863, 1965). Consistent with this observation are data showing increasing levels of α-adrenoreceptor responses and receptor density following estrogen administration to animals (Hoffman, B.B., T.N. Lavin, R.J. Lefkowitz and R.R. Ruffolo, Jr., Alpha adrenergic receptor subtypes in rabbit uterus: Mediation of mvometrial contraction and regulation by estrogens. J. Pharmacol. Exp. Ther., 219: 290-295, 1981, and Roberts, J.M., P.A. Insel and A. Goldfein, Regulation of mvometrial adrenoreceptors and adrenergic response by sex steroids. Mol. Pharmacol., 20: 52-58, 1981). Thus hormonal regulation of α-1 adrenoreceptor sensitivity could play a role in enhanced uterine contractions in dysmenorrhea, a condition for which selective α-1 adrenoreceptor antagonists could have therapeutic potential. There thus exists a need for a "uroselective" α-1 antagonist with reduced side effect habilities. Summary of the Invention In its principle embodiment, the present invention provides certain benzopyranopyrrole and benzopyranopyridine compounds and intermediates of formula I: I or a pharmaceutically acceptable salt thereof, wherein Rj and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, and R3 is selected from the group consisting of, wherein G and G' are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independently selected from the group consisting of oxygen, nitrogen, and sulfur, with the proviso that when Y is oxygen or sulfur, G is absent and when Y' is oxygen or sulfur, G' is absent, V and V are independently selected from the group of nitrogen and methine, and U is a ring that is fused to its adjacent ring and is selected from the group consisting of (a) an unsubstituted or substituted five member ring having five carbon atoms; (b) an unsubstituted or substituted five membered ring having four carbon atoms and one heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur; (c) an unsubstituted or substituted five membered ring having three carbon atoms and two heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur; (d) a substituted or unsubstituted six membered ring having six carbon atoms; (e) a substituted or unsubstituted six membered ring having 5 carbon atoms and one heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur; (f) a substituted or unsubstitued 6 membered ring having 4 carbon atoms and two heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur; and (g) a substituted or unsubstituted 6 membered ring having three carbon atoms and three heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur. The five membered rings constituting U may contain 0, 1, or 2 double bonds. The six membered rings constituting U may contain 0, 1, 2, or 3 double bonds. The rings (a)- (g) of the group constituting U may be mono or di-substituted with substituents indepedently selected from the group consisting of alkyl, alkoxy, cyano, nitro, carboxy, alkoxycarbonyl of two to eight carbon atoms, halogen, cycloalkyl, aryl, and heterocyclic. The present invention also relates to pharmaceutical compositions which comprise a therapeutically effective amount of a compound of formula I in combination with a pharmaceutically effective carrier. The present invention also relates to a method of antagonizing alpha- 1 adrenoreceptor binding in a host mammal, in particular humans, by administering a therapeutically effective amount of a composition comprising a compound of formula I. In particular, the present invention relates to a method of treating BPH in a mammal, in particular humans, by administering to a mammal an effective amount of a compound of formula I. Detailed Description of the Invention In one embodiment, the p ompound of the formula I, or a pharmaceutically acceptable salt thereof, wherein Ri and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, and R3 is selected from the group consisting of, wherein G and G' are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independently selected from the group consisting of oxygen, nitrogen, and sulfur, with the proviso that when Y is oxygen or sulfur, G is absent and when Y' is oxygen or sulfur, G' is absent, V and V are independently selected from the group of nitrogen and methine, and U is a ring that is fused to its adjacent ring and is selected from the group consisting of (a) an unsubstituted or substituted five member ring having five carbon atoms; (b) an unsubstituted or substituted five membered ring having four carbon atoms and one heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur; (c) an unsubstituted or substituted five membered ring having three carbon atoms and two heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur; (d) a substituted or unsubstituted six membered ring having six carbon atoms; (e) a substituted or unsubstituted six membered ring having 5 carbon atoms and one heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur; (f) a substituted or unsubstitued 6 membered ring having 4 carbon atoms and two heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur; and (g) a substituted or unsubstituted 6 membered ring having three carbon atoms and three heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur. The five membered rings constituting U may contain 0,1, or 2 double bonds. The six membered rings constituting U may contain 0,1,2, or 3 double bonds. The rings (a)- (g) of the group constituting U may be mono or di-substituted with substituents indepedently selected from the group consisting of alkyl, alkoxy, cyano, nitro, carboxy, alkoxycarbonyl of two to eight carbon atoms, halogen, cycloalkyl, aryl, and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. In a preferred embodiment, the present invention provides a compound of formula II: π wherein Ri and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, G and G' are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independently selected from the group consisting of oxygen, nitrogen, and sulfur, with the proviso that when Y is oxygen or sulfur, G is absent and when Y" is oxygen or sulfur, G' is absent, P', Q, S', and T are independently selected from the group consisting of nitrogen and methine, with the proviso that no more than two of P', Q, S', and T can be nitrogen, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. In another preferred embodiment, the present invention provides a compound of the formula HI: in wherein R \ and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, G and G' are independently selected from the group consisting hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independently selected from the group consisting of oxygen, nitrogen, and sulfur, with the proviso that when Y is oxygen or sulfur, G is absent and when Y' is oxygen or sulfur, G' is absent, P' and T are nitrogen, Q and S' are methine, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. In yet another preferred embodiment, the present invention provides a compound of formula IV: IV wherein Rj and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, G and G' are independently selected from the group consisting hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independently selected from the group consisting of oxygen, nitrogen, and sulfur, with the proviso that when Y is oxygen or sulfur, G is absent and when Y' is oxygen or sulfur, G' is absent, P' is nitrogen, Q, S', and T are me thine, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. In yet another preferred embodiment, the present invention provides a compound of formula V: V wherein Rj and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, G and G' are independently selected from the group consisting hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independently selected from the group consisting of oxygen, nitrogen, and sulfur, with the proviso that when Y is oxygen or sulfur, G is absent and when Y' is oxygen or sulfur, G' is absent, Q is nitrogen, P', S', and T are methine, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. In yet another preferred embodiment, the present invention provides a compound of formula VI: VI wherein R\ and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, G and G' are independently selected from the group consisting hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independently selected from the group consisting of oxygen, nitrogen, and sulfur, with the proviso that when Y is oxygen or sulfur, G is absent and when Y' is oxygen or sulfur, G' is absent, S' is nitrogen, P', Q, and T are methine, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. In yet another preferred embodiment, the present invention provides a compound of formula NH: vπ wherein Ri and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, G and G' are independently selected from the group consisting hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independently selected from the group consisting of oxygen, nitrogen, and sulfur, with the proviso that when Y is oxygen or sulfur, G is absent and when Y' is oxygen or sulfur, G' is absent, T is nitrogen, P', Q, and S' are methine, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof In yet another preferred embodiment, the present invention provides a compound of formula VHI: vm wherein Ri and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, G and G' are independently selected from the group consisting hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independently selected from the group consisting of oxygen, nitrogen, and sulfur, with the proviso that when Y is oxygen or sulfur, G is absent and when Y' is oxygen or sulfur, G' is absent, P', Q, S', and T are methine, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. In yet another preferred embodiment, the present invention provides a compound of formula DC: IX wherein Ri and R2 are independently selected from the group consisting of hydrogen, and alkoxy, A is methylene, n is 1, W is an alkylene of 2 to 10 carbon atoms, G is hydrogen, G' is absent, Y is nitrogen, Y' is sulfur, P', Q, S', are methine, T is nitrogen, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. In yet another preferred embodiment, the present invention provides a compound of formula X: X wherein Ri and R2 are independently selected from the group consisting of hydrogen, and alkoxy, A is methylene, n is 2, W is an alkylene of 2 to 10 carbon atoms, G is hydrogen, G' is absent, Y is nitrogen, Y' is sulfur, P', Q, and S' are methine, T is nitrogen, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. In yet another preferred embodiment, the present invention provides a compound of formula XI: XI wherein Ri and R2 are independently selected from the group consisting of hydrogen, and alkoxy, A is methylene, n is 2, W is an alkylene of 2 to 10 carbon atoms, G is hydrogen, G' is absent, Y is nitrogen, Y' is sulfur, Q and S' are methine, P' and T are nitrogen, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof In yet another preferred embodiment, the present invention provides a compound of formula XII: XII wherein Rj and R2 are independently selected from the group consisting of hydrogen, and alkoxy, A is methylene, n is 1, W is an alkylene of 2 to 10 carbon atoms, G is hydrogen, G' is absent, Y is nitrogen, Y' is sulfur, Q and S', are methine, P' and T are nitrogen, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. In yet another preferred embodiment, the present invention provides a compound of formula Xm: xm wherein Ri and R2 are independently selected from the group consisting of hydrogen, and alkoxy, A is methylene, n is 1, W is an alkylene of 2 to 10 carbon atoms, G is hydrogen, G' is absent, Y is nitrogen, Y' is sulfur, Q,S', and T are methine, P is nitrogen, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. In yet another preferred embodiment, the present invention provides a compound of formula XIV: XIV wherein Ri and R2 are independently selected from the group consisting of hydrogen, and alkoxy, Y is nitrogen, G is hydrogen, Y' is sulphur, P' and T are nitrogen, Q is methine, and S'is carbon; or a pharmaceutically acceptable salt, ester, or prodrug thereof. The present invention also relates to compounds or their salts which are useful as intermediates of Formulae I - XIV. One compound which is useful as an intermediate is a compound of formula XV: XV wherein Ri and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, and n is 1 or 0. Another compound which is useful as an intermediate is a compound of formula XVI: XVI wherein Ri and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, and n is 1 or 0. Another compound which is useful as an intermediate is a compound of formula XVII: XVII wherein Rj and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, m is from 2 to 10, and n is 1 or 0. A more preferred compound which is useful as an intermediate is a compound of formula X I: xvm wherein Ri and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, and n is 1 or 0. In addition, a more preferred compound of Formula XVIH is one having an absolute stereochemistry which is 3aR and 9bR. Another more preferred compound which is useful as an intermediate is a compound of formula XDC: XIX wherein Ri and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, and n is 1 or 0. In addition, a more preferred compound of Formula XDC is one having an absolute stereochemistry which is 3aR and 9bR. Another more preferred compound which is useful as an intermediate is a compound of formula XX: XX wherein \ and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, m is from 2 to 10, and n is 1 or 0. In addition, a more preferred compound of Formula XX is one having an absolute stereochemistry which is 3aR and 9bR. Another compound which is useful as an intermediate is a compound of formula XXI: XXI wherein U, Y\ G' are as defined in formulae I-XIV and R is alkyl. Another compound which is useful as an intermediate is a compound of formula XXII: XXII wherein U, Y', G' are as defined in formulae I-XIV and R is alkyl. Another compound which is useful as an intermediate is a compound of formula XXDI: XXIII wherein U, Y\ G', and m are as defined in formulae I-XIV and R is alkyl. Another compound which is useful as an intermediate is a compound of formula XXIV: XXIV, wherein Rz is alkyl. Another compound which is useful as an intermediate is a compound of formula XXV: XXV, wherein Rz is alkyl. " Another compound which is useful as an intermediate is a compound of formula XXVI: XXVI, wherein X is halogen and R is selected from alkyl and arylalkyl Another compound which is useful as an intermediate is a compound of formula XXVII: XXVII. Another compound which is useful as an intermediate is a compound of formula XXVHI: xxvπi. Another compound which is useful as an intermediate is a compound of formula XXDC: XXIX. The present invention also relates to a process for preparing a compound of the formula or a pharmaceutically acceptable salt, ester, or prodrug thereof, wherein R,, R^, A, n, W, Y, G, Y', G', P, Q, S, T, R 4 , and R 5 are as previously defined; comprising the steps of: a) reacting a compound of the formula wherein Ra is aminoalkyl, b) with a compound of the formula wherein R is alkyl. The present invention also relates to pharmaceutical compositions which comprise a therapeutically effective amount of a compound of formulae I - XIV in combination with a pharmaceutically acceptable carrier. The invention further relates to a method of antagonizing α- 1 adrenoreceptors in a host mammal, in particular humans, in need of such treatment by administering a therapeutically effective amount of a compound of formulae I - XIV. The invention still further relates to a method of treating BPH in a host mammal, in particular humans, in need of such treatment by administering a therapeutically effective amount of a compound of formulae I - XIV. The invention still further relates to a method of treating bladder outlet obstruction (BOO) in a host mammal, in particular humans, in need of such treatment by administering a therapeutically effective amount of a compound of formulae I - XTV. The invention still further relates to a method of treating neurogenic bladder in a host mammal, in particular humans, in need of such treatment by administering a therapeutically effective amount of a compound of formulae I - XIV. The invention still further relates to a method of treating uterine smooth muscle contraction in a female host mammal, in particular humans, in need of such treatment by administering a therapeutically effective amount of a compound of formulae I - XIV. As used throughout this specification and the appended claims, the following terms have the following meanings: The term "alkenyl" as used herein refers to a hydrocarbon containing at least one carbon- carbon double bond. Alkenyl groups include, for example, vinyl (ethenyl), allyl (propenyl), butenyl, l-methyl-2-buten-l-yl and the like. The terms "alkyl" or "loweralkyl" as used herein refer to straight or branched chain alkyl radicals containing from 1 to 6 carbon atoms including, but not limited to, methyl, ethyl, n- propyl, iso-propyl, n-butyl, iso-butyl, sec-butyl, t-butyl, n-pentyl, 1-methylbutyl, 2,2- dimethylbutyl, 2-methylpentyl, 2,2-dimethylpropyl, n-hexyl and the like. The term "alkylamino" as used herein refers to RioNH- wherein Rio is an alkyl group, for example, ethylamino, butylamino, and the like. The term "alkylene" denotes a divalent group derived from a straight or branched chain saturated hydrocarbon of from 2 to 10 carbon atoms by the removal of two hydrogen atoms, for example methylene, 1,2-ethylene, 1,1 -ethylene, 1,3-propylene, 2,2-dimethylpropylene, and the like. The term "alkoxy" as used herein refers to Ri lO- wherein Ri i is an alkyl group, as defined above. Examples of alkoxy include, but are not limited to, methoxy, ethoxy, tert- butoxy, and the like. The term "alkoxyalkyl" as used herein refers to an alkoxy group as previously defined appended to an alkyl radical as previously defined. Examples of alkoxyalkyl include, but are not limited to, methoxymethyl, methoxyethyl, isopropoxymethyl and the like. The term "alkoxy alkoxy" refers to R12O-R13O- wherein R12 is alkyl Rl3 is alkylene. Examples of alkoxyalkoxy include methoxymethoxy, methoxyethoxy and the like. The term "alkoxycarbonyl" as used herein refers to Ri4θ-C(O)- wherein R14 is an alkyl group. Examples of alkoxycarbonyl include methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl and the like. The term "alkylsulfonyl" refers to Rl5S(O)2- wherein R15 is an alkyl group. The term "alkynyl" refers to a straight or branched chain hydrocarbon containing a carbon-carbon triple bond. Examples of alkynyl include -C≡C-, -C≡C-CH2-, -G≡C- CH(CH 3 )- and the like. The term "amino" as used herein refers to -NH2. The term "aminoalkyl" as used herein refers to an alkyl radical to which is appended an amino group (-NH2). The term "aryl" as used herein refers to a mono- or bicyclic carbocyclic ring system having one or more aromatic rings including, but not limited to, phenyl, naphthyl, tetrahydronaphthyl, indanyl, indenyl and the like. Aryl groups can be unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, haloalkyl, alkoxy, thioalkoxy, amino, alkylamino, dialkylamino, hydroxy, halo, nitro, carboxy, alkoxycarbonyl and carboxamide. The term "arylalkyl" as used herein refers to an aryl appended to the parent molecular moiety through an alkyl radical. The term "carboxamide" as used herein refers to -C(O)NH2 wherein the carboxylic acid hydroxy moiety has been replaced by an amine. The term "carboxyalkyl" as used herein refers to a carboxy group (-C(O)OH) appended to an alkyl radical as previously defined. Examples of carboxyalkyl include carboxymethyl, carboxyethyl and the like. The term "cyanoalkyl" as used herein refers to a cyano group (-CN) appended to the parent molecular moiety through an alkyl radical. The term "dialkylamino" as used herein refers to R16R17N- wherein Ri6 and R 17 are independently alkyl, for example diethylamino, methyl propylamino, and the like. The term "carboxy" as used herein refers to a carboxylic acid radical, -C(O)OH. The term "cycloalkyl" as used herein refers to an aliphatic ring system having 3 to 10 carbon atoms and 1 to 3 rings including, but not limited to, cyclopropyl, cyclopentyl, cyclohexyl, norbornyl, adamantyl, and the like. Cycloalkyl groups can be unsubstituted or substituted with one, two or three substituents independently selected from alkyl, haloalkyl, alkoxy, thioalkoxy, amino, alkylamino, dialkylamino, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, alkoxycarbonyl and carboxamide. The term "halogen" or "halo" as used herein refers to I, Br, Cl, or F. The term "haloalkyl" as used herein refers to a lower alkyl radical, as defined above, bearing at least one halogen substituent, for example, chloromethyl, fluoroethyl or trifluoromethyl and the like. The terms "heterocyclic ring" or "heterocyclic" or "heterocycle" as used herein refers to any 3- or 4-membered ring containing a heteroatom selected from oxygen, nitrogen and sulfur; or a 5-, 6- or 7-membered ring containing one, two or three heteroatoms wherein the heteroatoms are independently selected from nitrogen, oxygen and sulfur. The 5-membered ring has from 0-2 double bonds and the 6- and 7-membered ring have from 0-3 double bonds. The nitrogen heteroatoms can be optionally quatemized. The term "heterocyclic" also includes bicyclic groups in which any of the above heterocyclic rings is fused to a benzene ring or a cyclohexane ring or another heterocyclic ring (for example, indolyl, quinolyl, isoquinolyl, tetrahydroquinolyl, benzofuryl or benzothienyl and the like). HeterocycUcs include: azetidinyl, pyrrolyl, pyrrolinyl, pyrrolidinyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, imidazolyl, imidazolinyl, imidazolidinyl, pyridyl, piperidinyl, homopiperidinyl, pyrazinyl, piperazinyl, pyrimidinyl, pyridazinyl, oxazolyl, oxazolidinyl, isoxazolyl, isoxazolidinyl, morpholinyl, thiazolyl, thiazolidinyl, isothiazolyl, isothiazolidinyl, indolyl, quinolinyl, isoquinolinyl, benzimidazolyl, benzothiazolyl, benzoxazolyl, furyl, thienyl and benzothienyl. Heterocyclics can be unsubstituted or monosubstituted or disubstituted with substituents independently selected from hydroxy, halo, oxo (=O), alkylimino (Ri8N= wherein Ri8 is a loweralkyl group), amino, alkylamino, dialkylamino, alkoxy, alkoxyalkoxy, haloalkyl, cycloalkyl, aryl, arylalkyl, -COOH, -SO3H and loweralkyl. In addition, nitrogen containing heterocycles can be N-protected. The term "(heterocyclic)alkyl" as used herein refers to a heterocyclic group as defined above appended to a loweralkyl radical as defined above. The term "hydroxy" as used herein refers to -OH. The term "hydroxyalkyl" as used herein refers to alkyl radical which is appended to an hydoxy group. The term "methine" as used herein refers to -CH=. The term "nitro" as used herein refers to -NO2. The term "thioalkoxy" as used herein refers to R19S- wherein R19 is alkyl. Examples of thioalkoxy include, but are not limited to, methylthio, ethylthio and the like. By "pharmaceutically acceptable salt" is meant those salts which are, within the scope of sound medical judgement, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response and the like, and are commensurate with a reasonable benefit/risk ratio. Pharmaceutically acceptable salts are well known in the art. For example, S.M. Berge, et al describe pharmaceutically acceptable salts in detail in J. Pharnu Sciences, __[: 1-19 (1977), which is hereby incoφorated by reference. The compounds of the present invention can be used in the form of salts derived from inorganic or organic acids. The salts can be prepared in situ during the final isolation and purification of the compounds of the invention, or separately by reacting the free base function with a suitable organic acid. These salts include, but are not limited to, the following: acetate, adipate, alginate, citrate, aspartate, benzoate, benzenesulfonate, bisulfate, butyrate, camphorate, camphorsulfonate, digluconate, cyclopentanepropionate, dodecylsulfate, ethanesulfonate, glucoheptanoate, glycerophosphate, hemisulfate, heptanoate, hexanoate, fumarate, hydrochloride, hydrobromide, hydroiodide, 2- hydroxy-ethanesulfonate, lactate, maleate, methanesulfonate, nicotinate, 2- naphthalenesulfonate, oxalate, pamoate, pectinate, persulfate, 3-phenylpropionate, picrate, pivalate, propionate, succinate, tartrate, thiocyanate, p-toluenesulfonate and undecanoate. Also, the basic nitrogen-containing groups can be quatemized with such agents as alkyl halides, such as methyl, ethyl, propyl, and butyl chloride, bromides, and iodides; dialkyl sulfates like dimethyl, diethyl, dibutyl, and diamyl sulfates, long chain halides such as decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides, aralkyl halides like benzyl and phenethyl bromides, and others. Water or oil-soluble or dispersible products are thereby obtained. Examples of acids which may be employed to form pharmaceutically acceptable acid addition salts include such inorganic acids as hydrochloric acid, sulphuric acid and phosphoric acid and such organic acids as oxalic acid, maleic acid, succinic acid and citric acid. Basic addition salts can be prepared in situ during the final isolation and purification of the compounds of formula (I), or separately by reacting the carboxylic acid function with a suitable base such as the hydroxide, carbonate or bicarbonate of a pharmaceutically acceptable metal cation or with ammonia, or an organic primary, secondary or tertiary amine. Pharmaceutically acceptable salts include, but are not limited to, cations based on the alkali and alkaline earth metals, such as sodium, lithium, potassium, calcium, magnesium, aluminum salts and the like, as well as nontoxic ammonium, quaternary ammonium, and amine cations, including, but not limited to ammonium, tetramethylammonium, tetraethylammonium, methylamine, dimethylamine, trimethylamine, triethylamine, ethylamine, and the like. Other representative organic amines useful for the formation of base addition salts include diethylamine, ethylenediamine, ethanolamine, diethanolamine, piperazine and the like. The term "pharmaceutically acceptable ester" as used herein refers to esters which hydrolyze in vivo and include those that break down readily in the human body to leave the parent compound or a salt thereof. Suitable ester groups include, for example, those derived from pharmaceutically acceptable aliphatic carboxylic acids, particularly alkanoic, alkenoic, cycloalkanoic and alkanedioic acids, in which each alkyl or alkenyl moiety advantageously has not more than 6 carbon atoms. Examples of particular esters includes formates, acetates, propionates, butyates, acrylates and ethylsuccinates. The term "pharmaceutically acceptable prodrug" as used herein refers to those prodrugs of the compounds of the present invention which are, within the scope of sound medical judgement, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response, and the like, commensurate with a reasonable benefit/risk ratio, and effective for their intended use, as well as the zwitterionic forms, where possible, of the compounds of the invention. The term "prodrug" refers to compounds that are rapidly transformed in vivo to provide the parent compound having the above formula, for example by hydrolysis in blood. A thorough discussion is provided in T. Higuchi and V. Stella, Pro-drugs as Novel Delivery Systems. Vol. 14 of the A.C.S. Symposium Series, and in Edward B. Roche, ed., Bioreversible Carriers in Drug Design. American Pharmaceutical Association and Pergamon Press, 1987, both of which are incoφorated herein by reference. As used throughout this specification and the appended claims, the term metabolically cleavable group denotes a moiety which is readily cleaved in vivo from the compound bearing it, wherein said compound, after cleavage remains or becomes pharmacologically active. Metabolically cleavable groups form a class of groups reactive with the carboxyl group of the compounds of this invention are well known to practitioners of the art. They include, but are not limited to groups such as, for example, alkanoyl, such as acetyl, propionyl, butyryl, and the like; unsubstituted and substituted aroyl, such as benzoyl and substituted benzoyl; alkoxycarbonyl, such as ethoxycarbonyl; trialkylsilyl, such as trimethyl- and triethysilyl; monoesters formed with dicarboxylic acids, such as succinyl, and the like. Because of the ease with which the metabolically cleavable groups of the compounds of this invention are cleaved in vivo, the compounds bearing such groups act as pro-drugs of α-1 adrenoreceptor antagonist compounds. The compounds bearing the metabolically cleavable groups have the advantage that they may exhibit improved bioavailability as a result of enhanced solubility and/or rate of absoφtion conferred upon the parent compound by virtue of the presence of the metabolically cleavable group. Compounds of the present invention include compounds which result from non-natural or synthetic preparations, including in vitro and in situ preparations, or as a result of in vivo preparation, e.g., in vivo metabolism. Asymmetric centers may exist in the compounds of the present invention. The present invention contemplates the various stereoisomers and mixtures thereof. Individual stereoisomers of compounds of the present invention are made by synthesis from starting materials containing the chiral centers or by preparation of mixtures of enantiomeric products followed by separation as, for example, by conversion to a mixture of diastereomers followed by separation by recrystallization or chromatographic techniques, or by direct separation of the optical enantiomers on chiral chromatographic columns. Starting compounds of particular stereochemistry are either commercially available or are made by the methods detailed below and resolved by techniques well known in the organic chemical arts. Representative compounds falling within the scope of formula I include: 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bS)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bS)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bS)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-6-chloro-pyrido[2 , ,3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bS)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-chloro-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bS)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-methoxy-pyrido[2',3 , :4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bS)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-j:i]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-6-methoxy-pyrido[2 , ,3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bS)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bS)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-chloro-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bS)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-l-(2-Methoxyethyl)-pyrazino[2',3 , :4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)- dione, 3-[4-((3aR,9bS)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-chloro-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-chloro-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-6-methoxy-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-6-methoxy-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-6-chloro-pyrido[2 , ,3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-6-chloro-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-[l]benzthieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-[ljbenzthieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[5-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)pentyl]-[l]benzthieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[5-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)pentyl]-[l]benzthieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy- 1 ,2,3,3a,4,9b-hexahydro-[ l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-chloro-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-methoxy-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-methoxy-pyrido[2',3':4,5]thieno[3,2-d]ρyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[3',4':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[4',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-methoxy-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-methoxy-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-chloro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-methoxy-pyrido[3 , ,2 , :4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[3 , ,2 , :4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-methyl-pyrido[3',2 , :4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-9-methoxy-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3- [4-((3aR,9bR)-cis-9-Methoxy- 1 ,2,3,3a,4,9b-hexahydro- [ 1 ]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-chloro-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-chloro-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[3',4':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[4 , ,3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-methoxy-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-methyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-methoxy-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2 > 4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-chloro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl] -9-methoxy-pyrido[3',4' :4,5] thieno[3 ,2-d] pyrimidine-2,4( 1 H,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[lJ-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-9-chloro-pyrido[3',4':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzoρyrano[3,4-c]pyrrol-2- yl)butyl]-8-isopropoxy-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyπOl-2- yl)butyl]-8-phenyl-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-6-chloro-pyrido[4',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-6-chloro-pyrido[4',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-methoxy-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-pyridyl)-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-thienyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]ρyrrol-2- yl)butyl]-8-(3-pyridyl)-pyrido[2',3 , :4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-thienyl)-pyrazino[2',3':4 ( 5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-pyridyl)-pyrazino[2 , ,3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-pyridyl)-pyrazino[2 , ,3 , :4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-furyl)-pyrazino[2 , ,3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[2-((±)-cis-7-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2-yl)ethyl]- [l]benzthieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[3-((±)-cis-7-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2-yl)propyl]- [l]benzthieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[2-((±)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2-yl)ethyl]- [l]benzthieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3- [3- ((±)-cis-9-Methoxy- 1 ,2,3,3a,4,9b-hexahydro-[ 1] -benzopyrano [3,4-c] pyrrol-2-yl)propyl] - [l]benzthieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[2-((±)-cis-6-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2-yl)ethyl]- [l]benzthieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[3-((±)-cis-6-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2-yl)propyl]- [l]benzthieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[2-((+)-cis-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2-yl)ethyl]- [l]benzthieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((±)-cis-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2-yl)butyl]- pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((±)-trans-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2-yl)butyl]- pyrido[2\3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((±)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((±)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2-yl)butyl]- pyrido[2',3 , :4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3- [4-((±)-trans-9-Methoxy- 1 ,2,3 ,3 a,4,9b-hexahydro- [ 1 ] -benzopyrano[3,4-c] pyrrol-2- yl)butyl]-pyrazino[2',3':4,5]thieno[3,2-d3pyrimidine-2,4(lH,3H)-dione, 3-[4-((±)-cis-8-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2-yl)butyl]- pyrido[3',2 , :4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((±)-cis-8-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2-yl)butyl]- pyrazino[2',3':4,5]thieno[3,2-d]ρyrimidine-2,4(lH,3H)-dione, 3-[3-((±)-cis-8-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2-yl)propyl]- pyrido[3',2 , :4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3- [2-((±)-cis-8-Methoxy- 1 ,2,3,3a,4,9b-hexahydro- [ 1 ] -benzopyrano [3 ,4-c]pyrrol-2-yl)ethyl] - pyrido[3\2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((±)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2-yl)butyl]- 6,7-dimethoxy-quinazoline-2,4(lH,3H)-dione, 3-[4-((±)-trans-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2-yl)butyl]-6,7- dimethoxy-quinazoline-2,4( 1 H,3H)-dione, 3-[4-((±)-cis-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2-yl)butyl]-6,7- dimethoxy-quinazoline-2,4( 1 H,3H)-dione, 3-[4-((±)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-6,7-dimethoxy-quinazoline-2,4(lH,3H)-dione, 3-[3-((±)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4-c]pyrido-3- yl)propyl]-6,7-dimethoxy-quinazoline-2,4( lH,3H)-dione, 3-[3-((±)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4-c]pyrido-3- yl)propyl]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((±)-trans- 10-Methoxy- 1 ,3,4,4a,5, 10b-hexahydro-2H-[ l]-benzopyrano[3,4-c]pyrido-3- yl)butyl]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((±)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4-c]pyrido-3- yl)butyl]-6,7-dimethoxy-quinazoline-2,4( 1 H,3H)-dione, 3-[4-((±)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4-c]pyrido-3- yl)butyl]-[l]benzthieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((±)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4-c]pyrido-3- yl)butyl]-pyrido[2 , ,3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[3-((+)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4-c]pyrido-3- yl)propyl]-[l]benzthieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[2-((±)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4-c]pyrido-3- yl)ethyl]-[l]benzthieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[2-((±)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4-c]pyrido-3- yl)ethyl]-6,7-dimethoxy-quinazoline-2,4( 1 H,3H)-dione, 3-[3-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)propyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[3-((4aR,10bS)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)propyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((4aR,10bS)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-ρyrido[2',3 , :4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione ) 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((4aR,10bS)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-8-chloro-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)- dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-8-chloro-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)- dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-8-methoxy-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)- dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-8-methoxy-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4(lH,3H)-dione, 3-[4-((4aS, 10bR)-trans- 10-Methoxy- 1 ,3,4,4a,5, 10b-hexahydro-2H-[ 1 ]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)- dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-8-phenyl-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)- dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-7-chloro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)- dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-7-methoxy-pyrido[3 , ,2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)- dione, 3- [4-(-cw-7-Hydroxy-9-methoxy- 1 ,2,3 ,3a,4,9b-hexahydro- [ 1 ] -benzopyrano[3 ,4-c]pyrrol-2- yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cw-6-Hydroxy-9-methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4- c]pyrrol-2-yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)- dione, 3-[4-((3aR,9bR)-cw-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(2-hydroxyphenyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-c _y-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-hydroxyphenyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4(lH,3H)-dione, and 3-[4-((3aR,9bR)-c 5-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(4-hydroxyphenyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4(lH,3H)-dione, or a pharmaceutically acceptable salt, ester, or prodrug thereof. Preferred compounds falling widiin the scope of formula (I) include: 3- [4-((3aR,9bR)-cis-9-Methoxy- 1 ,2,3 ,3a,4,9b-hexahydro- [ 1 ] -benzopyrano[3,4-c] pyrrol-2- yl)butyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[2',3 , :4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-chloro-pyrazino[2 , ,3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-chloro-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-methoxy-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-methoxy-pyrazino[2',3 , :4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-methoxy-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-chloro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-chloro-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-methoxy-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-methoxy-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-chloro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3 ) 4-c]pyrrol-2- yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-isopropoxy-pyrido[2 , ,3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-phenyl-pyrido[2 , ,3 , :4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[3-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)propyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-8-methoxy-pyrido[2 , ,3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)- dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-8-methoxy-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4(lH,3H)-dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)- dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-8-phenyl-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)- dione, 3-[4-((3aR,9bR)-cis-9-Methoxy- 1 ,2,3,3a,4,9b-hexahydro-[ l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-thienyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-pyridyl)-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bRr)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-pyridyl)-pyrazino[2 , ,3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-pyridyl)-pyrazino[2',3 , :4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-furyl)-pyrazino[2 , ,3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-thienyl)-pyrazino[2',3':4,5]thieno[3,2 ' -d]pyrimidine-2,4(lH,3H)-dione, 3-[4-(-cw-7-Hydroxy-9-methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-c.'_.-6-Hydroxy-9-methoxy- 1,2,3, 3a,4,9b-hexahydro-[l]-benzopyrano[3,4- c]pyrrol-2-yl)butyl]-8-phenyl-pyrazino[2 , ,3':4,5]thieno[3,2-d]ρyrimidine-2,4(lH,3H)- dione, 3-[4-((3aR,9bR)-c/_?-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(2-hydroxyphenyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-c _?-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-hydroxyphenyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4(lH,3H)-dione, and 3-[4-((3aR,9bR)-cw-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(4-hydroxyphenyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4(lH,3H)-dione, or a pharmaceutically acceptable salt, ester, or prodrug thereof. The following compounds may be prepared by the methods described in the synthetic Schemes and Examples contained herein: 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[2,3-g]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR cis-9-Methoxy- 1 ,2,3,3a,4,9b-hexahydro-[ l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl pyrido[3,4-g]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl pyrido[4,3-g]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl pyrido[3,2-g]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl pyrido[2,3-f]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR •cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl pyrido[3,4-f]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyi; pyrido[3,2-f]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR ■cis-9-Methoxy- 1 ,2,3,3a,4,9b-hexahydro-[ l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl pyrido[4,3-f]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR •cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl pyrido[2,3-h]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR ■cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl pyrido[3,4-h]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR ■cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl pyrido[3,2-h]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR ■cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl pyrido[4,3-h]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR ■cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl benz[g]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR ■cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl benz[h]quinazoline-2,4( 1 H,3H)-dione, 3-[4-((3aR,9bR ■cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl benz[f]quinazoline-2,4( 1 H,3H)-dione, 3-[4-((3aR,9bR -cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl pyrazino[2,3-f]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR -cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl ■pyrazino[2,3-gquinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR -cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl •pyrazino[2,3-h]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR -cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl ■pyridazino[3,4-f]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aR,9bR -cis-9-Methoxy- 1 ,2,3,3a,4,9b-hexahydro [l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl -pyridazino[4,3-f]quinazoline-2,4(lH,3H) dione, 3-[4-((3aR,9bR -cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro- [l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl -pyridazino[4,5-f]quinazoline-2,4(lH,3H) dione, 3-[4-((3aR,9bR -cis-9-Methoxy- 1 ,2,3,3a,4,9b-hexahydro- [ 1 ] -benzopyrano[3 ,4-c] pyrrol-2- yDbutyl -pyridazino[3,4-g]quinazoline-2,4(lH,3H )-dione, 3-[4-((3aR,9bR -cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro [l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl -pyridazino[4,3-g]quinazoline-2,4(lH,3H ) ' -dione, 3-[4-((3aR,9bR -cis-9-Methoxy- 1 ,2,3,3a,4,9b-hexahydro [ l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl -pyridazino[4,5-g]quinazoline-2,4(lH,3H )-dione, 3-[4-((3aR,9bR -cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro- [l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl -pyridazino[3,4-h]quinazoline-2,4(lH,3H )-dione, 3-[4-((3aR,9bR -cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro [l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl -pyridazino[4,3-h]quinazoline-2,4(lH,3H )-dione, 3-[4-((3aR,9bR -cis-9-Methoxy- 1 ,2,3,3a,4,9b-hexahydro- [ 1 ] -benzopyrano[3 ,4-c] pyrrol-2- yDbutyl -pyridazino[4,5-h]quinazoline-2,4(lH,3H )-dione, 3-[4-((3aR,9bR -cis-9-Methoxy- 1 ,2,3,3a,4,9b-hexahydro- [l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl -pyrimidino[4,5-fJquinazoline-2,4(lH,3H )-dione, 3-[4-((3aR,9bR -cis-9-Methoxy- 1 ,2,3,3a,4,9b-hexahydro [l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl -pyrimidino[5,4-f]quinazoline-2,4(lH,3H )-dione, 3-[4-((3aR,9bR -cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro- [l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl -pyrimidino[4,5-g]quinazoline-2,4(lH,3H )-dione, 3-[4-((3aR,9bR -cis-9-Methoxy- 1 ,2,3,3a,4,9b-hexahydro- [l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl -pyrimidino[5,4-g]quinazoline-2,4( 1 H,3H )-dione, 3-[4-((3aR,9bR -cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro [l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl -pyrimidino[4,5-h]quinazoline-2,4( 1 H,3H )-dione, 3-[4-((3aR,9bR cis-9-Methoxy- 1 ,2,3,3a,4,9b-hexahydro [l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl pyrimidino[5,4-h]quinazoline-2,4(lH,3H ))-dione, 3-[4-((3aS,9bR -trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl -pyrido[2,3-g]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR -trans-9-Methoxy- l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl -pyrido[3,4-g]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR -trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl -pyrido[4,3-g]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR -trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yDbutyl -pyrido[3,2-g]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[2,3-f]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[3,4-f]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[3,2-f]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[4,3-f]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[2,3-h]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[3,4-h]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[3,2-h]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]py ol-2- yl)butyl]-pyrido[4,3-h]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]ρyrrol-2- yl)butyl] -benz[g]quinazoline-2,4( 1 H,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-benz[h]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-benz[f]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrazino[2,3-f]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrazino[2,3-gquinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrazino[2,3-h]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyridazino[3,4-f]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyridazino[4,3-f]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyridazino[4,5-l]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyridazino[3,4-g]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyridazino[4,3-g]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyridazino[4,5-g]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyridazino[3,4-h]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzoρyrano[3,4-c]pyrrol-2- yl)butyl]-pyridazino[4,3-h]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyridazino[4,5-h]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy- 1 ,2,3,3a,4,9b-hexahydro-[ l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrimidino[4,5-f]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrimidino[5,4-f]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrimidino[4,5-g]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy- 1 ,2,3,3a,4,9b-hexahydro-[ l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrimidino[5,4-g]quinazoline-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrimidino[4,5-h]quinazoline-2,4(lH,3H)-dione, and 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrimidino[5,4-h]quinazoline-2,4(lH,3H)-dione, or a pharmaceutically acceptable salt, ester, or prodrug thereof Representative compounds of the present invention were evaluated for their ability to displace prazosin from its adrenoreceptor. In vitro Binding Assays In the following, for purposes of discussing alpha- 1 adrenoreceptor subtypes, the IUPHAR convention of using lower case letters to define molecular clones and upper case letters to indicate pharmacologically defined adrenoreceptors has been followed. Moreover, the newly recommended nomenclature for alpha- 1 (αι a , αi b , αu) has been used. Representative compounds of the invention were evaluated for α-adrenoreceptor binding affinity in vitro using [ 3 H]-prazosin as the radioligand and three cloned α-1 adrenoreceptors expressed in LTK cells: α- la (bovine), α-lb (hamster), and α-ld (rat). Additionally, binding affinity against the pharmacologically defined α-1 A adrenoreceptor (rat submaxillary gland) was measured. The cDNA clones encoding the α-1 adrenoreceptors ( α-la, α-lb, and α-ld) were obtained from TULCO (Triangle Universities Licensing Consortium, Research Triangle Park, NC) and inserted into the eukaryotic expression vector SnaB30. In this vector, expression of the adrenoreceptor gene is under the transcriptional control of an SV40 early promoter. Positive drug selection is provided by a neomycin-resistance gene. Mouse fibroblast cells (LTK) were transfected with the αi expression plasmids and grown in Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal calf serum and 30 μM G418. Stable G418 -resistant parental lines were generated, with successful expression of adrenoreceptor protein monitored using radioligand binding techniques. Stable single cell clones derived from the parental lines were screened in adrenoreceptor binding assays to identify clones having high adrenoreceptor density. Roller bottle cultures of the cloned lines were used to provide cell membranes for subsequent adrenoreceptor binding characterization studies. A cell line containing the SnaB30 vector expressing the human erythropoietin gene served as a negative control. For adrenoreceptor binding assays, large scale membrane preparations were utilized in which 6 million cells were seeded into small (450 cm 2 ) Co ing tissue culture roller bottles. 200 mL of DMEM containing 10% fetal calf serum and 300 μM G418 were added to each roller bottle. A 95% air / 5% CO2 gas mixture (sterile) was injected into each roller bottle prior to sealing. The bottles were then incubated at 37 °C on a roller rack for 5 days. Cells were re-fed with fresh medium after 3 days in culture. On the fifth day of culture, growth medium was removed from cells grown in roller bottles, and the cells were washed twice with PBS (Sigma, 120 mM NaCl, 2.7 mM KC1, 10 mM Na2HPO4-NaH2PO4, pH = 7.4). Cells were detached from the roller bottles by incubating for 15 minutes at 37 °C in a Tris-EDTA solution ( 10 mM Tris, 100 mM NaCl, 1 mM EDTA, pH = 7.4). The cell suspension from each roller bottle was decanted into tared centrifuge tubes and kept on ice. An aliquot of each cell suspension was generally taken for cell counting. Cells were centrifuged at 3000 X G for 5 min at 2-4 °C, washed with PBS and recentrifuged. The supernatant was decanted and die pellet weighed to determine the wet weight of cells. Cells were washed a final time in 40 vol 5 mM Tris-HCl, 5 mM EDTA, pH = 7.7, and centrifuged at 40,000 X G for 10 minutes. Cells were homogenized in 10 mL of 50 mM Tris-HCl, 5 mM EDTA (pH = 7.4) and diluted to 40 mLJtube. Homogenates were centrifuged at 40,000 X G for 10 minutes. The supernatant was decanted and the pellets rehomogenized in 50 mM Tris-HCl (pH = 7.4) and centrifuged as before. The supernatant was decanted and the homogenate resuspended in 6.25 volumes (per gram wet weight) of 50 mM Tris-HCl and aliquots of the pooled homogenates frozen in liquid N2 and stored at -70 °C until the time of assay. Rat submaxillary glands were used for α-1 A adrenoreceptors and were prepared essentially as described (Michel, A. D., Loury, D. N. and Whiting, R. L., Brit. J. Pharmacol. 9j£: 83-889 (1989)). Receptor binding assays for α-1 adrenoreceptors were performed essentially as described by Greengrass and Bremner (Eur. J. Pharmacol. __: 323-326 (1979)). Briefly, plastic Bioblocks™ (DBM Scientific, Valencia, CA) were incubated at 25 °C for 50 minutes with 500 μL of membrane homogenate (diluted with an additional 96 volumes [for cloned adrenoreceptors, 12 volumes for submaxillary gland] in 50 mM Tris-HCl buffer (pH = 7.7 at the time of assay), 450 μL of [ 3 H]prazosin (0.2 nM final concentration, 75-85 Ci/mmole, DuPont- NEN Coφ., Boston, MA) and 50 μL of either water (for total binding) or 10 μM phentolamine (final concentration, for non-specific binding). Following equiUbration, bound radioligand was separated from free on GF/B filters (presoaked in 0.5% polyethyleneimine) using either a Brandel or Packard cell harvester. Radioactivity was determined by standard Uquid scintiUation techniques. Data were analyzed as previously described (Hancock, A. A., Kyncl, J. J., Martin, Y. C. and DeBernardis, J. F., J. Receptor Res. &: 23-46 (1988)). Canine prostate strips were used in vitro as previously described (Hieble, J.P., Boyce, A.J. and Caine, M., Fed. Proc, 45 . : 2609-2614 (1986)), to determine antagonist potencies against phenylephrine-induced contractions. The results are shown in Table 1. The results show that the compounds of the invention bind to the α-1 adrenoreceptor and show varying degrees of specificity for the α-la adrenoreceptor. Table 1 In Vitro Data for Binding to α-1 Adrenoceptors Radioligand Binding (Ki, nM) 1A (Rat) la (Bovine) lb (Hamster) Id (Rat) 1 0.045 0.024 1.144 0.223 2 0.95 0.193 9.23 2.716 3 0.026 0.02 0.286 0.041 4 0.097 0.049 0.867 0.377 5 0.268 0.086 2.008 0.638 6 0.409 0.173 1.997 0.302 7 0.53 0.215 1.606 0.438 8 0.762 0.362 4.187 1.419 9 2.267 0.325 17.75 1.551 0.662 0.406 10.45 1.597 0.374 0.243 3.784 1.461 0.52 0.375 5.255 2.167 0.1 0.041 2.492 0.112 0.105 0.038 1.37 0.145 0.227 0.068 4.406 0.928 0.373 0.073 8.636 0.729 0.175 0.068 1.2475 0.19 0.284 0.069 5.055 0.79 0.059 0.025 1.13 0.108 0.208 0.038 3.505 0.439 0.03 0.018 0.326 0.03 0.196 0.031 1.163 0.138 0.743 0.046 0.973 0.639 5.37 0.616 5.557 4.512 0.061 0.03 0.591 0.039 0.09 0.022 0.376 0.017 0.121 0.044 0.974 0.094 0.273 0.092 3.694 0.195 0.252 0.095 3.69 0.466 0.264 0.066 2.673 0.222 0.224 0.06 4.787 0.344 1.011 0.093 9.952 0.86 0.811 0.082 10.451 0.701 0.474 0.079 3.367 0.339 0.312 0.057 5.121 0.436 0.539 0.124 2.854 0.36 0.264 0.069 3.343 0.195 0.376 0.057 5.63 0.897 0.343 0.226 31.915 2.145 22.845 3.015 33.778 7.123 0.069 0.031 0.603 0.041 0.073 0.028 0.829 0.066 0.1 14 0.037 1.485 0.063 0.043 0.043 0.622 0.081 0.125 0.066 1.341 0.104 0.353 0.033 2.577 0.114 0.245 0.038 2.402 0.189 0.037 0.007 0.129 0.019 0.475 0.048 5.749 0.467 1.934 0.335 20.787 0.391 1.188 0.064 0.868 0.371 3.981 1.083 13.575 0.597 0.872 0.037 9.419 0.664 0.077 0.187 1.004 0.173 0.111 0.103 1.458 0.02 0.614 0.078 10.202 1.307 0.682 0.078 19.3 0.507 0.273 0.188 2.079 0.039 0.166 0.049 6.74 0.257 0.187 0.078 14.155 1.821 0.152 0.15 8.851 0.336 982.857 52.015 1147.067 41 1.328 51.225 11.213 92.216 70.056 4.198 1.633 9.298 10.356 15.023 1.821 20.715 25.011 214.086 24.756 532.739 87.712 115.856 77.208 247.773 64.982 40.585 7.82 23.6 42.499 0.665 0.344 4.347 1.63 0.17 0.082 0.724 0.482 0.065 0.068 0.634 0.169 0.107 0.133 3.543 0.804 0.087 0.038 1.312 0.187 3.286 1.532 14.325 2.939 5.727 1.893 52.108 18.34 1 1.652 6.213 78.559 12.922 99.715 26.984 10000 105.832 0.297 0.122 1.883 0.478 0.199 0.174 0.821 0.361 0.442 0.17 2.504 0.765 0.045 0.052 0.192 0.108 82 0.577 0.361 4.898 1.577 83 0.383 0.217 3.069 0.807 84 0.479 0.617 4.916 1.123 85 0.419 0.336 1.886 0.566 86 0.54 0.202 1.707 0.398 87 0.371 0.227 2.857 0.704 88 0.188 0.11 0.791 0.259 89 0.133 0.038 0.111 0.061 90 0.323 0.135 2.294 0.439 91 0.102 0.066 1.459 0.495 92 3.845 2.196 45.066 18.494 93 4.044 1.204 3.667 11.524 94 0.185 0.097 1.967 0.361 95 8.834 1.804 21.594 23.036 96 0.816 0.211 10.382 0.816 97 0.892 0.097 4.696 0.247 98 1.023 0.121 2.654 0.324 99 14.939 1.726 57.075 5.808 100 30.546 5.826 26.984 7.59 101 1.267 0.063 8.415 0.597 102 1.894 0.113 6.26 0.651 103 0.909 0.115 3.327 0.243 104 3.59 0.427 266 5.20 105 26.3 6.42 1620 55.9 Prazosin 0.112 0.195 0.223 0.054 Terazosin 0.829 3.311 2.027 0.689 Doxazosin 0.423 0.912 0.793 0.231 Functional Antagonism at α- 1 Adrenoceptors Functional assays indicative of pharmacologically defined α- 1 adrenoreceptors were used to further characterize compounds. Inhibition of phenylephrine (PE)-induced contraction of canine prostate smooth muscle can be correlated with α-1 A adrenoreceptor activation. Inhibition of PE-induced contraction of rat spleen is representative of α- IB adrenoreceptor antagonism and inhibition of PE-induced contraction of rat vas deferens correlates with α-1 A adrenoreceptor antagonism (R. P. Burt, C. R. Chappie and I. Marshall, Br. J. Pharmacol. 107: P324 (1992)). For each of these models, agonist dose response curves were repeated against increasing concentrations of test agent to derive a Schild plot [log (EC 50 -1) against log (molarity of test agent)] to determine the pA 2 . Data for prazosin, terazosin and doxazosin actually demonstrate a more potent effect on spleen smooth muscle by approximately an order of magnitude. Canine prostate strips were used in vitro as previously described (Hieble, J.P., Boyce, A.J. and Caine, M., Fed. Proc, _[: 2609-2614 (1986)), to determine antagonist potencies against phenylephrine-induced contractions. The results are shown in Tables 2. The results show that the compounds of the invention exhibit functional antagonism of α-1 adrenoreceptors. Table 2. In Vitro Data for Functional Antagonism at α-1 Adrenoceptors In Vitro Characterization (pA2) Ex. No Rat Vas Rat Spleen Dog Prostate Rat Aorta 1 8.69 2 7.95 3 9.43 13 9.8 8.39 9.91 10.39 17 9.95 7.96 9.2 18 9.13 7.71 9.34 25 9.92 8.7 10.86 26 10.34 8.5 9.15 10.18 28 9.39 8.36 9.71 29 9.36 7.91 9.3 30 9.6 7.67 9.33 31 9.64 7.85 9.1 32 9.46 7.24 9.31 9.02 7.83 9.15 9.23 8.12 9.19 8.9 7.96 9.13 9.27 8.09 9.43 9.69 8.03 9.64 9.55 7.71 8.94 9.79 6.83 8.52 7.89 8.52 6.12 8.35 9.45 8.4 10.77 9.59 8.56 10.41 7.66 9.96 8.35 10.4 9.59 8.89 9.68 9.79 8.12 9.81 8.95 7.95 9.69 8.14 7.4 10.35 6.5 8.45 9.41 9.2 7.47 9.74 9.31 7.2 8.97 7.31 6.65 6.92 7.76 7.48 6.83 7.33 7.02 6.91 8.2 7.06 9.1 8.19 9.03 7.41 8.6 8.67 7.14 8.74 7.14 8.09 7.72 8.58 8.81 7.76 8.6 Prazosin 8.78 10.02 8.46 9.35 Terazosin 8.04 8.60 7.44 8.65 Doxazosin 8.69 9.51 7.59 8.97 In Vivo Determination of Intraurethral Pressure (TUP. in Canines The intraurethral pressure (IUP) model in aged canines is an accepted model of measuring the effect of prostate smooth muscle contraction on urethral tone. Canines also have an enclosed prostate covering the urethral shaft thus providing an anatomical correlate with humans. Beagle dogs (Marshall Farms) greater that 2 years of age and weighing between 12 and 15 kg were pre-anesthetized with thiopental sodium 15 mg/kg i.v. (Pen to thai™, Abbott) and then placed under general anesthesia (isoflurane). A 7F Swan-Ganz balloon catheter (Multiflex - Ust no. 41224-01, Abbott) was lubricated wiώ a water soluble jelly, inserted into the urethral orifice and advanced approximately 40 cm in male dogs (considerably less in females) until the baUoon tip was placed well inside the bladder. The balloon was then inflated with 1 mL of room air and the catheter slowly withdrawn just past the first resistance that is felt at the bladder neck. Preliminary experiments in which dogs were sacrificed after such placement confirmed that this technique results in consistent positioning of the balloon within the prostatic urethra in males or the corresponding location in females. The balloon port of the catheter was connected to a Gould Statham P23Dd pressure transducer interfaced to a computerized data acquisition system (Modular Instruments, Inc., Malvem, PA) for the measurement of intraurethral pressure (IUP). Dogs were then treated with propranolol to block the β-adrenoreceptor agonist effects of test agonists. Dose-response curves of the intraurethral pressor effect of epinephrine (EPI) were obtained before and after each of up to 3 increasing doses of a test antagonist (i.v.). Fifteen minutes was aUowed after each antagonist dose for equiUbration before the next agonist dose-response was initiated. The increase in IUP caused by a given agonist dose was allowed to return to basehne before the next dose was given. The estimated antagonist dissociation constant (in vivo pseudo pA2) was determined by Schild analysis (Brune, et al., Drug Development Research, 34:267-275 (1995). The results are shown in Table 3. The results indicate that the compounds of the invention inhibit EPI induced increases in IUP. Table 3 Inhibition of EPI Induced Increase in Canine IUP In Vivo Characterization (pseudo pA2) Ex. No. IUP 13 8.61 26 8.22 39 8.10 67 6.70 Prazosin 7.88 Terazosin 6.91 Doxazosin 6.90 Spontaneously Hypertensive Rat (SHR) Model The SHR model historically has been used as a predictor for the hypotensive effects of α-1 adrenoreceptor antagonists. Male spontaneously hypertensive rats were anesthetized and the left femoral artery and vein catheterized for the measurement of mean arterial pressure (MAP) and drug administration respectively. The arterial catheter was connected to a Gould Statham p23JD transducer and the pressure waveform was recorded. MAP (mm Hg) and heart rate (HR, beats/min.) were determined on-Une using a BUXCO Cardiovascular Analyzer. After a 30 minute pre-dose control period, each rat was given one dose of a test antagonist i.v. and the MAP and HR were monitored for an additional 2.5 hours. The area under the hypotensive response curve up to 60 minutes post dosing (TOO AUC) was determined using a trapezoidal rule integration of the percent change from control arterial pressure dataset. The results are expressed as a pED50 value, which is defined as the negative log of die dose that produced a hypotensive response of -1250, which constitutes 50% of the area under the curve between SHR and normotensive rats. The results are shown in Table 4. The results show that the compounds of the invention are weakly hypotensive. Table 4 Spontaneously Hypertensive Rat (SHR) Assay In Vivo Characterization (pseudo pA2) Ex. No. SHR 13 6.15 26 6.4 39 5.2 67 4 97 5.9 Prazosin 7.4 Terazosin 6.59 Doxazosin 6.74 Pharmaceutical Com Dositions The present invention also provides pharmaceutical compositions which comprise compounds of the present invention formulated together with one or more non-toxic pharmaceuticaUy acceptable carriers. The pharmaceutical compositions may be speciaUy formulated for oral administration in solid or Uquid form, for parenteral injection, or for rectal administration. The pharmaceutical compositions of this invention can be administered to humans and other animals oraUy, rectaUy, parenterally , intracisternally, intraperitoneally, topically (as by powders, ointments, or drops), bucally, or as an oral or nasal spray. The term "parenteral" administration as used herein refers to modes of administration which include intravenous, intramuscular, intraperitoneal, intrasternal, subcutaneous and intraarticular injection and infusion. Pharmaceutical compositions of this invention for parenteral injection comprise pharmaceutically acceptable sterile aqueous or nonaqueous solutions, dispersions, suspensions or emulsions as weU as sterile powders for reconstitution into sterile injectable solutions or dispersions just prior to use. Examples of suitable aqueous and nonaqueous carriers, diluents, solvents or vehicles include water, ethanol, polyols (such as glycerol, propylene glycol, polyethylene glycol, and the like), and suitable mixtures thereof, vegetable oils (such as olive oil), and injectable organic esters such as ethyl oleate. Proper fluidity can be maintained, for example, by the use of coating materials such as lecithin, by the maintenance of the required particle size in the case of dispersions, and by the use of surfactants. These compositions may also contain adjuvants such as preservative, wetting agents, emulsifying agents, and dispersing agents. Prevention of the action of microorganisms may be ensured by the inclusion of various antibacterial and antifungal agents, for example, paraben, chlorobutanol, phenol sorbic acid, and the like. It may also be desirable to include isotonic agents such as sugars, sodium chloride, and the like, Prolonged absoφtion of the injectable pharmaceutical form may be brought about by the inclusion of agents which delay absoφtion such as aluminum monostearate and gelatin. In some cases, in order to prolong the effect of the drug, it is desirable to slow the absoφtion of the drug from subcutaneous or intramuscular injection. This may be accompUshed by the use of a Uquid suspension of crystaUine or amoφhous material with poor water solubility. The rate of absoφtion of the drag then depends upon its rate of dissolution which, in turn, may depend upon crystal size and crystalUne form. Alternatively, delayed absoφtion of a parenteraUy administered drug form is accomplished by dissolving or suspending the drug in an oil vehicle. Injectable depot forms are made by forming microencapsule matrices of the drag in biodegradable polymers such as polylactide-polyglycoUde. Depending upon the ratio of drag to polymer and the nature of the particular polymer employed, die rate of drug release can be controlled. Examples of other biodegradable polymers include poly(orthoesters) and poly(anhydrides) Depot injectable formulations are also prepared by entrapping the drug in liposomes or microemulsions which are compatible with body tissues. The injectable formulations can be sterilized, for example, by filtration through a bacterial-retaining filter, or by incoφorating sterilizing agents in the form of sterile solid compositions which can be dissolved or dispersed in sterile water or other sterile injectable medium just prior to use. Solid dosage forms for oral administration include capsules, tablets, pills, powders, and granules. In such solid dosage forms, the active compound is mixed with at least one inert, pharmaceutically acceptable excipient or carrier such as sodium citrate or dicalcium phosphate and/or a) fillers or extenders such as starches, lactose, sucrose, glucose, mannitol, and silicic acid, b) binders such as, for example, carboxymethylcellulose, alginates, gelatin, polyvinylpyrroUdone, sucrose, and acacia, c) humectants such as glycerol, d) disintegrating agents such as agar-agar, calcium carbonate, potato or tapioca starch, alginic acid, certain silicates, and sodium carbonate, e) solution retarding agents such as paraffin, f) absoφtion accelerators such as quaternary ammonium compounds, g) wetting agents such as, for example, cetyl alcohol and glycerol monostearate, h) absorbents such as kaolin and bentonite clay, and i) lubricants such as talc, calcium stearate, magnesium stearate, solid polyethylene glycols, sodium lauryl sulfate, and mixtures thereof. In the case of capsules, tablets and pills, the dosage form may also comprise buffering agents. Solid compositions of a similar tyrje may also be employed as fiUers in soft and hard- filled gelatin capsules using such excipients as lactose or milk sugar as well as high molecular weight polyethylene glycols and the like. The solid dosage forms of tablets, dragees, capsules, pills, and granules can be prepared with coatings and shells such as enteric coatings and other coatings weU known in the pharmaceutical formulating art They may optionaUy contain opacifying agents and can also be of a composition that they release the active ingredient(s) only, or preferentially, in a certain part of the intestinal tract, optionally, in a delayed manner. Examples of embedding compositions which can be used include polymeric substances and waxes. The active compounds can also be in micro-encapsulated form, if appropriate, with one or more of the above-mentioned excipients. Liquid dosage forms for oral administration include pharmaceutically acceptable emulsions, solutions, suspensions, syraps and eUxirs. In addition to the active compounds, the liquid dosage forms may contain inert diluents commonly used in the art such as, for example, water or other solvents, solubiUzing agents and emulsifiers such as ethyl alcohol, isopropyl alcohol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3- butylene glycol, dimethyl formamide, oils (in particular, cottonseed, groundnut, com, germ, olive, castor, and sesame oils), glycerol, tetrahydrofurfuryl alcohol, polyethylene glycols and fatty acid esters of sorbitan, and mixtures thereof. Besides inert dUuents, the oral compositions can also include adjuvants such as wetting agents, emulsifying and suspending agents, sweetening, flavoring, and perfuming agents. Suspensions, in addition to the active compounds, may contain suspending agents as, for example, ethoxylated isostearyl alcohols, polyoxyethylene sorbitol and sorbitan esters, microcrystaUine ceUulose, aluminum metahydroxide, bentonite, agar-agar, and tragacanth, and mixtures thereof. Compositions for rectal administration are preferably suppositories which can be prepared by mixing the compounds of this invention with suitable non-irritating excipients or carriers such as cocoa butter, polyethylene glycol or a suppository wax which are solid at room temperature but Uquid at body temperature and therefore melt in the rectum and release the active compound. Compounds of the present invention can also be administered in the form of liposomes. As is known in the art, liposomes are generally derived from phospholipids or other lipid substances. Liposomes are formed by mono- or multi-lamellar hydrated liquid crystals that are dispersed in an aqueous medium. Any non-toxic, physiologically acceptable and metabolizable lipid capable of forming liposomes can be used. The present compositions in liposome form can contain, in addition to a compound of the present invention, stabilizers, preservatives, excipients, and the like. The preferred lipids are the phosphoUpids and the phosphatidyl choUnes (lecithins), both natural and synthetic. Methods to form liposomes are known in the art. See, for example, Prescott, Ed., Methods in Cell Biology. Volume XIV, Academic Press, New York, N.Y. (1976), p. 33 et seq. Dosage forms for topical administration of a compound of this invention include powders, sprays, ointments and inhalants. The active compound is mixed under sterile conditions with a pharmaceuticaUy acceptable carrier and any needed preservatives, buffers, or propellants which may be required. Opthalmic formulations, eye ointments, powders and solutions are also contemplated as being within the scope of this invention. Actual dosage levels of active ingredients in the pharmaceutical compositions of this invention may be varied so as to obtain an amount of the active compound(s) that is effective to achieve the desired therapeutic response for a particular patient, compositions, and mode of administration. The selected dosage level wiU depend upon die activity of the particular compound, the route of administration, the severity of the condition being treated, and the condition and prior medical history of the patient being treated. However, it is widiin the skill of the art to start doses of die compound at levels lower than required for to achieve the desired therarjeutic effect and to graduaUy increase the dosage untU the desired effect is achieved. Generally dosage levels of about 0.01 to about 50, more preferably of about 0.05 to about 5 mg of active compound per kilogram of body weight per day are administered oraUy to a mammaUan patient. If desired, the effective daily dose may be divided into multiple doses for puφoses of administration, e.g. two to four separate doses per day. Methods for preparing the compounds of the invention are shown in Schemes 1-9. In the following Schemes, Ri and R2 are independently selected from die group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl. In the following schemes, n=l or 2, m=l-6, R= alkyl, and Y, G, G', U, and U' are as defined previously. Scheme 1 illustrates the general procedure for the preparation of the compounds of this invention. The secondary amine 1 is elaborated to the compounds of this invention (7) by one of two general methods. Alkylation of 1 with a haloalkyl nitrile in the presence of a non- nucleophiUc base, such as ethyldiisopropylamine, K2CO3, or the like to yield an intermediate nitrile (2) which is then reduced using LiAltLt, AIH3, BH3, catalytic hydrogenation, or die like produces the intermediate aminoalkyl substituted analog 3. Treatment of mis amine with a heterocycUc isocyanate of the general formula 5 yields an intermediate urea, which either spontaneously cyclizes to the pyrimidinedione product 7, or does so under base catalysis. Alternatively, when R is other than H, the carbamoyl chloride 6 replaces the isocyanate 5. Alternatively, the secondary amine 1 can be reacted wiϋi the haloalkyl heterocyclic urea of the general formula 4 in the presence of a non-nucleophilic base such as ethyldiisopropylamine, K2CO3, or the like to the yield the title compounds of the invention (7) directly. The amine 1, where n=l, is prepared as outlined in Scheme 2 (for cis ring fusion) and Scheme 3 (for trans ring fusion). For the cis fused product, treatment of the appropriately substituted coumarin 8 with the azomethine ylide precursor N-trimethylsilylmethyl-N- methoxymethyl-benzylamine 9 produces the cyclized product 10 selectively as the cis isomer. Reduction of the lactone with LiAlH4, BH3, A1H3, LiBtLj, or the like yield the alcohol 11. Activation of the primary alcohol as a chloride 12, bromide, mesylate, or the like, foUowed by treatment with a base, such as KOtBu, NaOMe, NaOH, K2CO3, or the like results in cyclization to the cis fused benzopyranopyrrole nucleus 13. Removal of the benzyl group from the amine, most conveniently achieved by catalytic hydrogenation, yields the cis fused secondary amine 14. For the trans fused product, treatment of the appropriately substituted trans cinnamate 15 (Scheme 3) with the azomethine ylide precursor N-trimethylsilylmethyl-N-methoxymethyl- benzylamine 9 produces the cycUzed product 16 selectively as the trans isomer. Reduction of the ester with LiAlt j, BH3, AIH3 or the like, followed by hydrolysis of the phenol protecting group, yields the alcohol 17. Activation of the primary alcohol as a chloride 18, bromide, mesylate, or the like, followed by treatment with a base, such as KOtBu, NaOMe, NaOH, K2CO3, or the like results in cyclization to the trans fused benzopyranopyrrole nucleus 19. Removal of the benzyl group from the amine, most conveniently achieved by catalytic hydrogenation, yields the trans fused secondary amine 20. In a preferred embodiment of this invention, substitution of the azomethine ylide precursor 21, derived from (R)-α-methylbenzyl amine, for 9, derived from benzyl amine, allows for synthesis of the preferred (3aR, 9bR) amine 22 from 5-methoxycoumarin (Scheme 4), and the preferred (3aS, 9bR) amine 23 from the ethyl 2-methoxy-6-methoxymethyl-trans- cinnamate (Scheme 5). In Scheme 4, the reagents PPh3/CC14 may be replaced using methanesulfonyl chloride and triethylamine. In another preferred embodiment of this invention, a precursor of a compound of formula 1 wherein n=2, (4aR,10bS)-trα/τ_.-10-Methoxy- l,3,4,4a,5,10b-hexahydro-2H-[l]- benzopyrano[3,4-c]pyridine (28) is prepared as show in Scheme 6. The imide 24 is prepared from ethyl 2-methoxy-6-methoxymethyl cinnamate and ethyl N-benzylamidomalonate according to the method of Faruk and Martin, U. S. Patent No. 4,902,801. Reduction with LiAlH4, AIH3, BH3, or the like, foUowed by conversion of the primary alcohol to a suitable leaving group, such as chloro, bromo, mesylate, or the like; hydrolysis of the protected phenol, and intramolecular cycUzation, foUowed by debenzylation yields the racemic tr /w-lO-Methoxy- l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4-c]pyridine 25. Reaction of the secondary amine with a chiral chloroformate, such as menthyl chloroformate, yields a mixture of diastereomeric carbamates, which can then be separated chromatographically. Removal of the carbamate group by treatment with n-BuLi then yields the enantiomerically resolved secondary amine 28. In another preferred embodiment of the present invention, the compounds of Formulae I-XIV and Formulae XXI-XXV may be prepared as shown in Scheme 7. Condensation of phenylglyoxal mono oxime (30) with 2-aminomalononitrile tosylate salt (31) followed by reduction of the resulting pyrazine N-oxide (32) with triethylphosphite, sodium bisulfite, triphenylphosphine, or the like, regioselectivity yields 33. Diazotization of the amino functionaUty, foUowed by displacement with CuBr, CuCl or the like, yields the intermediate chloro- or bromopyrazine (34), which upon base promoted condensation with methyldiioglycolate yields the diienopyrazine intermediate (35). Use of other aUcylthioglycolates such as ethyl, n-propyl, n-alkyl, or substituted alkyls would yield alternative diienopyrazine intermediates with differentiated alkyl groups on the ester. Reaction of the thienopyrazine intermediate (35) widi phosgene, diphosgene, triphosgene, or the like, in the presence of an inert solvent produces the isocyanate (36) of Formula XXV. In another preferred embodiment of the present invention, a compound of XV-XX may be prepared according to the method outlined in Scheme 8. Activation of the free hydroxyl of (37) as a methanesulfonate, toluenesulfonate, benzenesulfonate, or the like, or as a halide, foUowed by nucleophilic displacement with 2-bromo-or 2-iodoresorcinol mono methyl ether yields the ether intermediate (40). The ether intermediate (40) where X=Br or I may be cycUzed by forming the enolate of the lactam with a metal amide (such as KHMDS, LiHMDS, LDA, NaNH 2 , KNH 2 , or the like) and exposing to a metal salt (Cu+, Cu2+, Mn2+, Fe2+, Fe3+, and the like) similar to the work of McKillop (McKillop, J. Chem. Soc, Perkin Trans, L, 1993, 2433), herein incoφorated entirely by reference. Alternatively, a metal enolate of the lactam (40) can be exposed to a transition metal complex (such as Pd/C or Pd(PPh 3 ) 4 ) or a transition metal salt complex (salts of Pd2+ that may or may not be complexed to phosphines, amines, or nitriles) in order to make the compound (41) where R is an unsubstituted benzyl group. Deprotection of 41 can be accomplished using catalytic hydrogenation conditions. The alkylation of 42 with a haloalkyl nitrile in the presence of a non-nucleophilic base, such as ethyldiisopropylamine, K2Co3, or the like, to yield an intermediate nitrile (43) which is then reduced using LiAlH4, A1H3, BH3, catalytic hydrogenation, or the like, produces the intermediate aminoalkyl substitiuted analog (44). In another embodiment of the present invention, a lactam intermediate may be prepared as shown in Scheme 9 by reacting 1 -hydroxy- 2-formaldehyde-3-metiιoxybenzene (45) in a protic solvent, such as iso-propyl alcohol or the like, with a teriary amine base, such as DABCO or the like, and methyl acrylate to produce the chromene (47). Condensation of the chromene witrh nitromethane in the presence of a non-nucleophilic base such as DBU or potassium tert- butoxide or die like yields die intermediate nitroester (48) which is then reduced to the lactam (49) using catalytic hydrogenation and a base such as sodium methoxide or the like. Scheme 1 Scheme 2 Scheme 3 Scheme 4 Scheme 5 Scheme 6 3aS, lObR 3aR, lObS 28 29 Scheme 7 PhenyL .N, ΪN X=halogen 36 Scheme 7b Phenyl^CHO + / "" ΛJH *. Pheny ^ss^ 55-61% from Phenyl-SH PhCH 2 CHO j 35 Scheme 8 43 44 Scheme 9 49 48 The foregoing may be better understood by reference to the foUowing examples which are provided for iUustration and not intended to limit the scope of the inventive concept. The following abbreviations are used: K2CO3 for potassium carbonate, LiAlH4 for lithium aluminum hydride, AIH3 for aluminum hydrate, BH3 for borane, BH3 DMS for borane dimethylsulfide complex, DABCO for l,4-diazabicyclo[2.2.2]octane, DBU for 1,8- diazabicyclo[5.4.0]undec-7-ene, DMF for dimethylformamide, DMSO for dimethylsulfoxide, Et3N for triethylamine, Et2θ for diethyl ether, EtOAc for ethyl acetate, EtOH for ethanol, KOtBu for potassium tert-butoxide, LDA for Uthium diisopropylamide, MeOH for metiianol, NaOMe for sodium methoxide, NaOH for sodium hydroxide, HCl for hydrochloric acid, H2 Pd for hydrogen and a palladium catalyst, iPrOH for isopropyl alcohol and THF for tetrahydrofuran, cat. TFA for catalytic trifluoroacetic acid, PPh3/CCl4 for triphenyl phosphine/ carbon tetrachloride, and n-BuLi for n-butyllithium. Example 1 3-μ-(T3aR.9bR -c .y-9-Methoxy-1.2.3.3a.4.9h-hexahydro-ril-henzopyranor3.4-clpyrrol-2- ynhutyll-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione hvdroch1oride Example 1A GaR.9bRVef.γ-9-Methoxy-2-rRV -methylbenzyl-1.2.3.3a.4.9b-hexahvdro-π i- benz;opyraoQr3,4-c1pyrrol-4-one 5-Methoxycoumarin (22.3 g, 126 mmol) and trifluoroacetic acid (0.97 mL, 12.6 mmol) were combined in CH2CI2 (200 mL) and cooled to 0° C. To the stirred solution was added N- memoxymethyl-N-trimethylsUylmethyl-(R)-α-methylbenzylamine (63.4 g, 252 mmol) over 30 min. The reaction was stirred an additional 30 min at 0° C, and then 1 hr at 25° C. The reaction mixture was washed with 5% NaHCO3, the organic layer was dried and evaporated. The resulting oU was suspended in diethyl ether, and after 2 hr, the title compound was collected by filtration, (15.4 g, 38%). *H NMR (300 MHz, CDCI3) δ 1.36 (d, 3H), 2.41 (dd, IH), 3.04 (d, IH), 3.05-3.15 (m, 2H), 3.23 (m, IH), 3.32 (1, IH), 3.75 (m, IH), 3.79 (s, 3H), 6.61 (d, IH), 6.67 (d, IH), 7.18 (t, IH), 7.20-7.35 (m, 5H). Example IB (-3aR.9hRVri.v-9-Methoxy-2-(RVα-methylhenzyl-1.2.3.3a.4.9h-hexahvdro-ril- benzopyrano ^-clpyrrole The resulting product from Example 1 A (15.3 g, 47 mmol) in THF (200 mL) was added to a suspension of LiAlH4 (3.6 g, 94 mol) in THF (200 mL) over 15 min. After 2 hr at 25° C, the reaction was quenched (Fieser workup), and the intermediate alcohol isolated by evaporation of solvent. The alcohol (15.2 g, 46 mmol) was combined with triphenylphosphine (24.3 g, 93 mmol) in a 4:1 mixture of acetonitrile and CCI4, and the resulting solution was heated to reflux for 1 hr. The solvent was evaporated and the resulting product was isolated as a mixture of the title compound and an intermediate chlorophenol. The mixture was treated with 1 M potassium t-butoxide (12 mmol) in THF (50 mL). Solvent was evaporated and the product was partitioned between dil aq. NaOH and etiiyl actetate. The organic phase was dried and evaporated to yield, after chromatographic purification, 11.9 g (84%) of the tide compound: H NMR (300 MHz, CDCI3) δ 1.36 (d, 3H), 2.23-2.31 (m, 2H), 2.59 (m, IH), 3.04 (dd, IH), 3.20 (q, IH), 3.23 (q, IH), 3.38 (q, IH), 3.77 (s, 3H), 3.81 (q, IH), 4.01 (q, IH), 6.41 (d, IH), 6.52 (d, IH), 7.04 (t, IH), 7.20-7.35 (m, 5H). Example 1 r3aR.9hRVe/.γ-9-Methoxv-1.2.3.3a.4.9h-hexahvdro-ril-benzopyranor3.4-clpyrrole The product from Example IB (7.7 g, 24.9 mmol) was dissolved in methanol (300 mL) and palladium hydroxide on charcoal (1.5 g) was added. The reaction was stirred rapidly under one atomsphere of H2 for 18 hr. The reaction was filtered and evaporated to yield the title compound (4.6 g, 90%): H NMR (300 MHz, CDCI3) δ 2.55 (m, IH), 2.67 (dd, IH), 2.80 (dd, IH), 3.21 (q, IH), 3.32 (dd, IH), 3.62 (dd, IH), 3.70 (m, IH), 3.81 (s, 3H), 4.10 (dd, IH), 6.46 (d, IH), 6.55 (d, IH), 7.17 (t, IH); [α] D -95.7° (MeOH). Example ID C3aR.9hR _-eι.γ-2-f3-cyanopropylV9-Methoxy-1.2.3.3a.4.9h-hexahvdro-πi-henzopvranor3.4- g.pyrrole The product from Example 1C (7.0 g, 34 mmol) was combined with 4- bromobutyronitrile (5.6 g, 37.5 mmol) and ethyldiisopropylamine (8.9 mL, 51 mmol) in acetonitrile (50 mL), and the reaction was stirred at 80° C for 4 hr. The reaction was quenched in 5% aq. NaHCO3 and extracted with CH2CI2. The organic extracts were washed with brine, dried and evaporated. The resulting product was purified by column chromatography to yield the title compound (7.5 g, 81%): l H NMR (300 MHz, CDCI3) δ 1.82 (m, 2H), 2.30 (m, 2H), 2.43 (t, 2H), 2.45-2.65 (m, 3H), 3.04 (dd, IH), 3.23-3.42 (m, 2H), 3.79 (dd, IH), 3.82 (s, 3H), 4.06 (dd, IH), 6.46 (d, IH), 6.54 (d, IH), 7.07 (t, IH). Example IE GaR.9hRV .γ-2-('4-aminohutylV9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4- cl pyrrole LiAfflU (7.8 g, 207 mmol) was suspended in THF (200 mL) and cooled to 0° C. To the suspension was added AICI3 (9.2 g, 69 mmol) in small portions over 15 min. The product from Example ID (7.5 g, 27.5 mmol) in THF (50 mL) was then added over 15 min, and the reaction was allowed to warm to 25° C and stir for 1.5 hr. The reaction was quenched by the addition of 10.5 mL H2O. 10.5 mL 15% aq. KOH, and 42 mL H2O. The reaction was filtered though cetite, and the solvent evaporated to yield the title compound (6.6 g, 87%): l H NMR (300 MHz, CDCI3) δ 1.65-1.80 (m, 4H), 2.19 (m, IH), 2.25 (dd, IH), 2.42 (m, IH), 2.52 (t, 2H), 3.14 (dd, IH), 3.18-3.30 (m, 2H), 3.79 (dd, IH), 3.80 (s, 3H), 4.04 (dd, IH), 6.46 (d, IH), 6.54 (d, IH), 7.07 (t, IH). Example IF 3-r4-((3aR.9bRVc .v-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-c1pyrro1-2- vnhutvn-pyridor2'.3 , :4.51thienor3.2-dlpyrimidine-2.4dH.3H)-dione hvdrochloride Methyl 3-amino-thieno[3,2-b]pyridine-2-carboxylate, prepared by the procedure described in J. Heterocyclic Chem., 24: 85 (1987), (0.624 g, 3.00 mmol) and triethylamine (0.84 mL, 6.0 mmol) were dissolved in THF (20 mL), and to the solution was added 1.7 mL of a 1.93 M solution of phosgene in toluene (3.3 mmol). After 2h, the product from Example IE (0.78 g, 2.8 mmol) was added. After 4h, the reaction was quenched in aq. 5% NaHCO3, and extracted with CH2CI2. The organic extracts were dried, and evaporated. The resulting urea was dissolved in toluene (100 mL) and heated to reflux for 18 h. The cooled reaction mixture was filtered, and the resulting free base of the title compound was treated with anhydrous HCl in ethanol. Addition of diethyl edier resulted in crystaUization of the title compound (0.76 g, 57%): m.p. 241-243° (dec); l H NMR (300 MHz, CDCI3 (free base)) δ 1.56-1.99 (m, 2H), 1.71-1.83 (m, 2H), 2.26 (t, J=9 Hz, IH), 2.34 (dd, J=6, 10 Hz, IH), 2.50-2.70 (m, 3H), 3.26 (dd, J=7, 10 Hz, IH), 3.43 (q, J=8 Hz, IH), 3.63 (t, J=8 Hz, IH), 3.79 (s, 3H), 3.76- 3.86 (m, IH), 4.01 (dd, J=4, 11 Hz, IH), 4.11 (t, J=7 Hz, IH), 6.43 (d, J=8 Hz, IH), 6.49 (d, J=8 Hz, IH), 7.04 (t, J=8 Hz, IH), 7.49 (dd, J=4, 8 Hz, IH), 8.23 (dd, J=l, 8 Hz, IH), 8.78 (dd, J=l, 4 Hz, IH); MS (DCI(NH 3 )) m/e 479 (M+H)+; Analysis calc'd for C25H26N 4 O4S « HCl'(H 2 O)o.25: C, 57.80; H, 5.34; N, 10.78; found: C, 57.72; H, 5.46; N, 10.58. Example 1G Alternative synthesis of( " 3aR.9bR)-c. ' _.-2-(4-aminobutyl)-9-Methoxy- 1.2.3.3a.4.9b-hexahydro- r 11 -benzopyrano 3 ,4-cl pyrrole To a solution of 5-metiιoxycoumarin in THF at 15°C, was added trifluoroacetic acid. To this was added a solution of N- methoxymetiiyl-N trimethylsilylmethyl-(R)-α- methylbenzylamine in t-butylmethyl ether. After the addition was complete, the mixture was stirred at 25°C for 1 hour and then concentrated in-vacuo. The residue was dduted with ethyl acetate, stirred for 1.5 hours at 5 C, and filtered. The filtercake was washed with ethyl acetate and dried to yield (3aR,9bR)-c _v-9-Methoxy-2-(R)- -methylbenzyl- l,2,3,3a,4,9b-hexahydro- [l]-benzopyrano[3,4-c]pyrrol-4-one. Lithium borohydride and tetrahydrofuran were combined and cooled to less than -10°C. A solution of pyrroUdine lactone in tetrahydrofuran was slowly added while keeping the temperature below 0°C. The solution was stirred at approx 5°C for 1 hour and then distilled under vacuum. Methanol was added to the residue and the contents were refluxed for 2 hours. A solution of ammonium choride in water was added and the reaction mixture was distiUed under vacuum at less than 55°C. The residue was extracted with toluene and the toluene layer was washed with distilled water. The washed toluene layer was then distilled down under vacuum at less than 55°C. Tetrahydrofuran was added to the toluene and cooled to 0+10°C and triethylamine was added. Methanesulfonyl chloride in toulene was added and the mixture was stirred at 0±10°C for 1 hour. A solution of potassium t-butoxide in tetrahydrofuran was added and stirred below 10°C for not less tiian 1 hour. Toluene was added and die layers were washed with ammonium chloride in water followed by distiUed water. A sample of die solution may then be concentrated in- vacuo. Alternatively, the material could be purified by concentrating in-vacuo to an od, adding isopropanol and then anhydrous hydrogen chloride in isopropanol. The solution was stirred for 3 hours at room temperature and the resultant slurry was filtered. The filter cake was washed with isopropanol and dried in an oven at 35°C for 16 hours to yield the hydrochloride salt (3aR,9bR)-cώ-9-Methoxy-2-(R)-α-methylbenzyl-l,2,3,3a,4,9b-hexahydro-[l]- benzopyrano [3 ,4-c] pyrrole To a solution of (3aR,9bR)-cis-9-methoxy-2-(R)-α-methylbenyl-l,2,3,3a,4,9b- hexahydro-[l]- benzopyrano[3,4-c]pyrrole hydrochloride in ethanol was added 50% wet 5% paUadium on carbon. The flask was purged with hydrogen and heated to 50°C at 5Opsi for lόhours. The catalyst was filtered and die solvent removed under vacuum at approx. 40°C to yield the hydrochloride salt of (3aR,9bR)- _.-9-Methoxy- 1,2,3, 3a,4,9b-hexahydro-[l]- benzopyrano[3,4-c]pyrrole. The product from Example 1C (7.0 g, 34 mmol) was combined with 4- bromobutyronitrile (5.6 g, 37.5 mmol) and ethyldiisopropylamine (8.9 mL, 51 mmol) in acetonitrile (50 mL), and the reaction was stirred at 80° C for 4 hr. The reaction was quenched in 5% aq. NaHCO3 and extracted witii CH2CI2. The organic extracts were washed with brine, dried and evaporated. The resulting product was purified by column chromatography to yield (3aR,9bR)-cw-2-(3-cyanopropyl)-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4- cjpyrrole. Alternative to the process in Example IE, a nitrogen purged hydrogenator was charged with Raney Nickel and methanol. The slurry was stin-ed and allowed to settle. The supemate was removed via a diptube. The residue was then sluiτied again with methanol and the supemate again removed with a diptube. This was repeated a third and fourth time. The Raney Nickel was then slurried with methanol and a solution of the product from example ID in methanol was added. The internal temperature was cooled to approx. 0°C and ammonia added. The hydrogenator was pressure purged three times with hydrogen and pressurized to 50psi. The solution was hydrogenated at approx. 25°C for 2 hours. Once the reaction was complete, the catalyst was filtered dirough a bed of celite and die filtercake washed witii methanol. The combined filtrates were then charged to anotiier reactor and distilled under vacuum at less than 40°C to a residue. Toluene was added, foUowed by a solution of sodium hydroxide in water. The biphasic solution was filtered dirough a pad of celite into anotiier reactor and die layers separated. Tho organics were washed widi water and the toluene distilled under vacuum at less than 45°C to yield the primary amine. Example IH Synthesis of Compound 40 in Scheme 8 To a solution of water (500mL) and itaconic acid (108.9g, O.83mol) was added phenethylamine (101.4g, O.83mol). This was heated to reflux for 24h, cooled to room temperature, and die Uquid decanted. The solid was tiien dissolved into 40% aqueous etiianol (800mL) at reflux. The solution was slowly cooled to room temperature and filtered. The filtercake was washed with water (200mL), twice with ethanol (200mL each), and dried to give 82. lg of a white solid. A solution of the white soUd (82g, 0.35mol) in methanol (500mL) was heated to reflux with trimethylorhoformate (37.3g, 0.35mol) and sulfuric acid (ca 0.5g) for 16h. This was cooled to room temperature and sodium borohydride (26.48g, ϋ.7mol) was added portionwise. The solution was then heated to reflux for 2h, concentrated in-vacuo ca 300mL. The solution was dUuted with aqueous ammonium chloride (200mL) and extracted widi etiiyl acetate (once widi 500mL, 3 times with 300mL). The combined organic layers were concentrated in-vacuo to an oil (34g) of the compound (37) that was comparable to the previously reported compound (Domagala, J. Med. Chem., 1987, 30, 1711). To a solution of alcohol, compound (37) (30g, 0.137mol) in THF (300mL), was added triethylamine (13 .84g, 0.137mol) followed by tosyl chloride (26.08g, 0.13.7mol). This was stirred 14h at room temperature. The reaction was diluted witii ethyl acetate (300mL) and washed witii 5% sodium bicarbonate (400mL), and twice with 1% sodium bicarbonate (300mL), dried over sodium sulfate, and concentrated in-vacuo to an oil of the compound (38): ΗNMR (CDCI 3 ) δ 7.78 (d, 2H, J=8Hz), 7.4-7.2 (m, 7H), 5.45 (q, IH, J=6,5Hz), 4.0-3.9 (m, 2H), 3.1-3.0 (m, 2H), 2.65-2.5 (m, IH), 2.4 (d, IH, J=12Hz), 2.45 (s, 3H), 2.15-2.05 (m, IH), 1.43 (d, 3H, J=7Hz). To a solution of 3-methoxyphenol (lOOg, 0.81 mol) m methylene chloride (500mL) was added dihydropyran (184mL, 2.01mol) and pyridinium p-toluenesulfonate (lO.lg, 0.04mol) at room temperature. This solution was stirred at room temperature for 5h before quenching with saturated sodium bicarbonate (250mL). The organics were separated and the aqueous extracted twice widi methylene chloride (250mL). The combined organics were tiien washed widi saturated NaCl (250mL), dried over sodium sulfate and concentrated in-vacuo to an oil (184g). To die resulting oil (10.45g, 50mmol) in heptane (210mL) at 0°C, was added 1.6M 5 butyl-Uthium (45mL, 72mmol). This was stirred for 3 hours and then quenched witii a solution of iodine (22. lg 8.7mmol) in either (250mL). The reaction mixture was then stirred for 30min at 0°C, quenched with sat. sodium bisulfate (200mL) and extracted with other (3x250mL). The combined organics were washed with sat. sodium bisulfate (200mL), saL NaCl (200mL), and dried over sodium sulfate. Concentration in-vacuo yielded an oil. The crude oU was dissolved in o ethanol (250mL) and pyridinium p-toluenesulfonate was added. The mixture was heated to 70°C for 1.5h, cooled to room temperature, dduted with ethyl acetate (250mL) and washed with sat NaCl (250mL). The aqueous was extracted again twice widi ethyl acetate (250mL). The organics were combined, dried over sodium sulfate, and concentrated in-vacuo to an oU of d e compound (39): MS (CI) m/z (rel intensity 250 ([M+I] + 100). 5 To a solution of the 2-bromophenol (1.73g, lOmmol) in DMF (20mL) at 0°C was added potassium tertbutoxide (1.12g, lOmmol). This was stirred for 15min at 0°C before adding the compound from example 38 (3.73g, lOmmol). This was heated to 60°C for 16h, cooled to room temperature, dUuted with ethyl acetate (200mL) and washed twice widi water (lx200mL, lxlOOmL). The organics were dried over sodium sulfate and concentrated in-vacuo to approx. 0 20mL. This was diluted 1 : 1 (v/v) widi heptane and passed through a pad of silica (1.5g). The eluent was concentrated in-vacuo to give the compound (40) (3g, 80%) as an oil. Example 2 5 3-r4-((3aS.9hS -e/.γ-9-Methoχy-1.2.3.3a.4.9b-hexahvdiO-r n-benzopyranor3.4-c1pyrrol-2- yl)butyll-pyridor2 , .3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H -dione hydrochloride Example 2A (3aS.9hSVd.γ-9-Methoxy-2-(SV -methylbenzyl- 1.2.3.3a.4.9h-hexahvdro-πi- 0 benzopyrano[3.4-c1pynOl-4-one 5-Methoxycoumarin and N-methoxymethyl-N-trimethylsilylmethyl-(S)-α- methylbenzylamine were treated in an analogous manner as described in Example 1 A. *H NMR (300 MHz, CDC1 3 ) δ 1.36 (d, 3H), 2.41 (dd, IH), 3.04 (d, IH), 3.05-3.15 (m, 2H), 3.23 5 (m, IH), 3.32 (1, IH), 3.75 (m, IH), 3.79 (s, 3H), 6.61 (d, IH), 6.67 (d, IH), 7.18 (t, IH), 7.20-7.35 (m, 5H). Example 2B r3aS.9hSVm-9-Methoxy-2-(S)- -methylbenzyl-1.2.3.3a.4.9h-hexahvdro-rn- benzopyrano[3.4-clpyrrole The resulting product from Example 2A was treated in an analogous manner as described in Example IB. *H NMR (300 MHz, CDC1 3 ) δ 1.36 (d, 3H), 2.23-2.31 (m, 2H), 2.59 (m, IH), 3.04 (dd, IH), 3.20 (q, IH), 3.23 (q, IH), 3.38 (q, IH), 3.77 (s, 3H), 3.81 (q, IH), 4.01 (q, IH), 6.41 (d, IH), 6.52 (d, IH), 7.04 (t, IH), 7.20-7.35 (m, 5H). Example 2C f3aS.9hSV /.γ-9-Methoxv-1.2.3.3a.4.9h-hexahvdro-rn-benzopvranor3.4-c1pvrrole The product from Example 2B was treated in an analogous manner as described in Example lC. l U NMR (300 MHz, CDCI3) δ 2.55 (m, IH), 2.67 (dd, IH), 2.80 (dd, IH), 3.21 (q, IH), 3.32 (dd, IH), 3.62 (dd, IH), 3.70 (m, IH), 3.81 (s, 3H), 4.10 (dd, IH), 6.46 (d, IH), 6.55 (d, IH), 7.17 (t, IH); [α] D MeOH +95.2°. Example 2D ( , 3aS.9hSVe .y-2-r3-cvanopropyl)-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzoρyranor3.4- clpyrrole The product from Example 2C was treated in an analogous manner as described in Example ID. l H NMR (300 MHz, CDCI3) δ 1.82 (m, 2H), 2.30 (m, 2H), 2.43 (t, 2H), 2.45- 2.65 (m, 3H), 3.04 (dd, IH), 3.23-3.42 (m, 2H), 3.79 (dd, IH), 3.82 (s, 3H), 4.06 (dd, IH), 6.46 (d, IH), 6.54 (d, IH), 7.07 (t, IH). Example 2E (3aS.9bS)-c ^-2-(4-aminobutyl -9-Methoxy-1.2.3.3a.4.9b-hexahydro- ll-benzopyrano 3.4- clpyrrole The product from Example 2D was treated in an analogous manner as described in Example IE. l H NMR (300 MHz, CDCI3) δ 1.65-1.80 (m, 4H), 2.19 (m, IH), 2.25 (dd, IH), 2.42 (m, IH), 2.52 (t, 2H), 3.14 (dd, IH), 3.18-3.30 (m, 2H), 3.79 (dd, IH), 3.80 (s, 3H), 4.04 (dd, IH), 6.46 (d, IH), 6.54 (d, IH), 7.07 (t, IH). Example 2F 3-r4-fr3aS.9hSVcf.v-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-benzopyranor3.4-c1pyrrol-2- vnbutvl1-pvridor2'.3':4.51thienor3.2-dlpvrimidine-2.4(lH.3m-dione hydrochloride The product from Example 2E (0.800 g, 2.9 mmol) and methyl 3-amino-thieno[3,2- b]pyridine-2-carboxylate (0.624 g, 3.00 mmol) were treated as described in Example IF to yield 1.1 g (79 %) of the title compound: m.p. 241-243° (dec); l H NMR (300 MHz, CDCI3 (free base)) δ 1.56-1.99 (m, 2H), 1.71-1.83 (m, 2H), 2.26 (t, J=9 Hz, IH), 2.34 (dd, J=6, 10 Hz, IH), 2.50-2.70 (m, 3H), 3.26 (dd, J=7, 10 Hz, IH), 3.43 (q, J=8 Hz, IH), 3.63 (t, J=8 Hz, IH), 3.79 (s, 3H), 3.76-3.86 (m, IH), 4.01 (dd, J=4, 11 Hz, IH), 4.11 (t, J=7 Hz, IH), 6.43 (d, J=8 Hz, IH), 6.49 (d, J=8 Hz, IH), 7.04 (t, J=8 Hz, IH), 7.49 (dd, J=4, 8 Hz, IH), 8.23 (dd, J=l, 8 Hz, IH), 8.78 (dd, J=l, 4 Hz, IH); MS (DCI(NH 3 )) m/e 479 (M+H)+; Analysis calc'd for C25H26N4O 4 S « HCl « (H 2 O)o.25: C, 57.80; H, 5.34; N, 10.78; found: C, 57.85; H, 5.46; N, 10.65. Example 3 3-r4-((3aS.9hR.-trfl«.γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-clpyrrol-2- yl .hutyll-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione hydrochloride Example 3A 3-(R)-(2-Hydroxy-6-methoxy)phenyl-4-rS)-hydroxymethyl-N-(R)-α-methylbenzyl-pyrrolidine Ethyl 2-methoxy-6-methoxymethyl-cinnamate (36 g, 160 mmol) and trifluoroacetic acid (1.23 mL, 16 mmol) were combined in CH2CI2 (800 mL) and cooled to 0° C. To the stirred solution was added N-methoxymethyl-N-trimethylsilylmethyl-(R)-α-methylbenzylamine (80 g, 320 mmol) in 200 mL CH2CI2 over 30 min. The reaction was stirred an additional 2.5 hr at 0° C. The reaction mixture was washed with 5% NaHCθ3, the organic layer was dried and evaporated. The crude product was dissolved in THF (150 mL) and added to a stirred suspension of LiAlFLj. (12.1 g, 320 mmol). The reaction was quenched, (Fieser workup), filtered through ceUte, and evaporated. The product was dissoved in methanol (850 mL) and 4N HCl (120 mL) was added. After heating at reflux for 2h, the solvent was evaporated, and the residue was partitioned between sat. NaHCO3 solution and ethyl acetate. The organic extracts were dried and evaporated. The crude product was purified by chromatography, eluting 2:1 diethyl etheπhexane to yield 22.1 g (42%) of the title compound as the faster moving diastereomer: *H NMR (300 MHz, CDCI3) δ 1.48 (d, 3H), 1,81 (t, IH), 2.16 (m, IH), 2.36 (m, IH), 2.58 (t, IH), 3.05 (t, IH), 3.40 (m, 2H), 3.53 (m, 2H), 3.80 (dd, IH), 3.83 (s, 3H), 6.38 (d, IH), 6.60 (d, IH), 7.05 (t, IH), 7.22-7.40 (m, 5H), 12.62 (br s, IH). Example 3B GaS.9hRV/rαn.v-9-Methoxy-2-rRV -methylbenzyl-1.2.3.3a.4.9h-hexahvdro-m- benzopyranor3.4-clpyrrole The product from Example 3A (22.1 g, 67.0 mmol) was dissolved in 290 mL of a 4: 1 mixture of acetonitrile and CCL4. To the solution was added triphenylphosphine (35.4 g, 135 mmol) and the reaction was heated to 80° C for 20 min. The reaction was concentrated, and passed through a silica gel column, eluting with 1:1 hexane:diethyl ether. The product, which contained a mixture of the title compound and the chloro intermediate, was dissolved in THF (300 mL) and 41 mL of 1.0M potassium t-butoxide in THF was added. After 18 hr, the THF was evaporated and die resulting product partitioned between IN NaOH and diethyl ether. The organic extracts were dried and evaporated, and the resulting product was chromatographed over sUica gel, eluting 1:1 hexane:diethyl ether to yield 13.2 g (63%) of the titie compound: *H NMR (300 MHz, CDCI3) δ 1.45 (d, 3H), 2.28 (m, IH), 2.44 (dd, IH), 2.70-2.90 (m, 2H), 3.54 (m, IH), 3.69 (s, 3H), 3.70 (q, IH), 3.99 (dd, IH), 4.38 (dd, IH), 6.37 (d, IH), 6.47 (d, IH), 7.04 (t, IH), 7.20-7.40 (m, 5H). Example 3C (3aS.9hR .-trαn.γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-clpyrrole The product from Example 3B (13.0 g, 42 mmol) was treated as described in Example 1C to yield 8.08 g (94%) of the title compound: H NMR (300 MHz, CDCI3) δ 2.07 (br s, IH), 2.24 (m, IH), 2.70 (m, 2H), 2.84 (t, IH), 3.21 (dd, IH), 3.77 (s, 3H), 3.83 (dd, IH), 4.07 (dd, IH), 4.53 (dd, IH), 6.40 (d, IH), 6.51 (d, IH), 7.06 (t, IH); [α] D MeOH -94.8°. Example 3D (3aS.9bR)-trQn.v-2-r3-cvanopropyl.-9-Methoxy-1.2.3.3a.4.9b-hexahydro-ril- benzopyranor3.4-clpyrrole The product from Example 3C (8.0 g, 39 mmol), 4-bromobutyronitrile (6.3 g, 43 mmol), and dUsopropylethylamine (7.6 g, 58 mmol) were treated as described in Example ID to yield 7.1 g (67%) of the title compound: l U NMR (300 MHz, CDCI3) δ 1.84 (m, 2H), 2.30 (m, IH), 2.46 (t, 2H), 2.55 (dd, IH), 2.70-2.85 (m, 4H), 2.91 (dd, IH), 3.52 (m, IH), 3.78 (s, 3H), 4.06 (dd, IH), 4.45 (dd, IH), 6.39 (d, IH), 6.49 (d, IH), 7.05 (t, IH). Example 3E (3aS.9hR)-tron.y-2-( ' 4-aminohutvl.-9-Methoxv-1.2.3.3a.4.9b-hexahvdro-rn-henzopyranor3.4- c] pyrrole The product from Example 3D (7.1 g, 26 mmol) was treated as described in Example IE to yield 6.29 g (87%) of the titie compound: l NMR (300 MHz, CDC1 3 ) δ 1.40-1.80 (m, 4H), 2.32 (m, IH), 2.57 (t, IH), 2.62-2.90 (m, 4H), 2.95 (t, IH), 3.60 (m, IH), 3.78 (s, 3H), 4.06 (dd, IH), 4.45 (dd, IH), 6.40 (d, IH), 6.49 (d, IH), 7.04 (t, IH). Example 3F 3-r4-(f3aS.9hR)-tro«.v-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-benzopyranor3.4-clpyrrol-2- yl.butyll-pyridor2'.3':4.51thienor3.2-d1pyrimidine-2.4(lH.3HVdione hydrochloride The product from Example 3E (0.800 g, 2.9 mmol) and mediyl 3-amino-thieno[3,2- b]pyridine-2-carboxylate (0.624 g, 3.00 mmol) were treated as described in Example IF to yield 0.70 g (50 %) of the title compound: m.p. > 255°; *H NMR (300 MHz, DMSO-dό (free base)) δ 1.42-1.54 (m, 2H), 1.60-1.72 (m, 2H), 2.04-2.18 (m, IH), 2.25-2.89 (m, 4H), 3.10- 3.48 (m, 3H), 3.68 (s, 3H), 3.95 (t, J=7 Hz, 2H), 4.02 (dd, J=10, 12 Hz, IH), 4.39 (dd, J=4, 10 Hz, IH), 6.39 (dd, J=l, 8 Hz, IH), 6.44 (dd, J=l, 8 Hz, IH), 7.01 (t, J=8 Hz, IH), 7.64 (dd, J=5, 8 Hz, IH), 8.63 (dd, J=l, 8 Hz, IH), 8.83 (dd, J=l, 5 Hz, IH); MS (DCI(NH )) m/e 479 (M+H) + ; Analysis calc'd for C25H26N 4 0 4 S'HCl « (H2O)o.5: C, 57.30; H, 5.39; N, 10.69; found: C, 57.08; H, 5.43; N, 10.80. Example 4 3-r4-( ' (3aR.9hSVtr< v-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4-clpyrrol-2- yl)butyll-pyrido[2'.3':4.51thieno 3.2-d1pyrimidine-2.4(lH.3H)-dione hydrochloride Example 4A (3aR.9hS -trαn..-2-f4-aminohutvn-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-rn-henzopyranor3.4- clpyrrole Ethyl 2-methoxy-6-methoxymethyl-cinnamate and N-methoxymethyl-N- trimethylsilylmethyl-(S)-α-methylbenzylamine were treated, in an analogous manner as described in Examples 3A-E: H NMR (300 MHz, CDC1 3 ) δ 1.40-1.80 (m. 4H), 2.32 (m, IH), 2.57 (t, IH), 2.62-2.90 (m, 4H), 2.95 (t, IH), 3.60 (m, IH), 3.78 (s, 3H), 4.06 (dd, IH), 4.45 (dd, IH), 6.40 (d, IH), 6.49 (d, IH), 7.04 (t, IH). Example 4B 3-r4- ( (3aR.9bS ) -tr-yty-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-c1pyrrol-2- yl)butvn-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione hydrochloride The product from Example 4A (680 mg, 2.5 mmol) and methyl 3-amino-thieno[3,2- b]pyridine-2-carboxylate (520 mg, 2.5 mmol) were treated as described in Example IF to yield 0.75 g (63 %).: m.p. > 255°; l H NMR (300 MHz, DMSO-d 6 (free base)) δ 1.42-1.54 (m, 2H), 1.60-1.72 (m, 2H), 2.04-2.18 (m, IH), 2.25-2.89 (m, 4H), 3.10-3.48 (m, 3H), 3.68 (s, 3H), 3.95 (t, J=7 Hz, 2H), 4.02 (dd, J=10, 12 Hz, IH), 4.39 (dd, J=4, 10 Hz, IH), 6.39 (dd, J=l, 8 Hz, IH), 6.44 (dd, J=l, 8 Hz, IH), 7.01 (t, J=8 Hz, IH), 7.64 (dd, J=5, 8 Hz, IH), 8.63 (dd, J=l, 8 Hz, IH), 8.83 (dd, J=l, 5 Hz, IH); MS (DCI(NH 3 )) m/e 479 (M+H)+; Analysis calc'd for C25H26N 4 O 4 S-HCl « (H2O)o.25: C, 57.80; H, 5.34; N, 10.78; found: C, 57.45; H, 5.35; N, 10.80. Example 5 3-r4-((3aR.9bS)-trαn -9-Methoxy-1.2.3.3a.4.9b-hexahydro-ril-benzopyranor3.4-clpyrrol-2- vnbutyl1-6-chloro-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4πH.3H)-dione dihydrochloride Example 5A Methyl 3-amino-5-chlorothienor3.2-blpyridine-2-carboxylate and Methyl 3-amino-7- chlorothienor3.2-blpyridine-2-carboxylate To a solution of 3-chloro-2-cyanopyridine (40g, 0.29 mol) in 500 mL acetic acid was added hydrogen peroxide (30 %, 52 g, 0.45 mol) dropwise. After stirring at 90°C for 18 h, the reaction is cooled to 25°C and a solution of sodium sulfite (57 g, 0.45 mol) in H2O was added dropwise. The reaction was concentrated to remove the bulk of die acetic acid and die residue is partitioned between 1 M NaOH and CH2CI2. The CH2CI2 layer was dried (MgSO4), filtered, concentrated, and recrystallized from EtOAc to provide 23 g (51 %) of 3-chloro-2- cyanopyridine-N-oxide. The resulting N-oxide (12.2 g, 79 mmol) was dissolved in DMF (160 mL) at 0°C. Methyl thioglycolate (7.1 mL, 79 mmol) was added followed by sodium methoxide (8.5 g, 160 mmol) in portions. The reaction was stirred for 1 h. The reaction was poured onto ice and the resulting soUd was coUected by filtration, washed with water, dissolved in CH2CI2, dried (MgSO4), filtered, concentrated, and recrystallized from EtOAc. 10.6 g (60 %) of methyl 3-amino-thieno[3,2-b]pyridine-4-oxide carboxylate was obtained. The pyridine- N-oxide (10.6 g, 47 mmol) was mixed with phosphorous oxychloride (100 mL). The reaction was heated to 80°C for 30 min. The reaction was concentrated and partitioned between CH2CI2 and 5% aq.NaHCC»3 solution. The CH2CI2 layer was dried (MgSO 4 ), filtered, concentrated, and chromatographed (5:1 hex:EtOAc) to yield methyl 3-amino-5-chloro-thieno[3,2-b]pyridine- 2-carboxylate (8.3g, 73 %): *H NMR (300 MHz, CDC13) d 3.92 (s, 3H), 6.15 (bs, 2H), 7.37 (d, IH), 7.99 (d, IH); MS (DCI NH3) m/e 243 (M+H)+; followed by methyl 3-amino-7- chloro-thieno[3,2-b]pyridine-2-carboxylate (2.0 g, 18 %): *H NMR (300 MHz, CDC13) d 3.93 (s, 3H), 6.20 (bs, 2H), 7.41 (d, IH), 8.54 (db, IH); MS (DCI/NH3) m/e 243 (M+H)+. Example 5B 3-r4-rr3aR.9hS .-trα«.y-9-Methoxy-1.2.3.3a.4.9h-hexahvdiO-f n-benzopyranor3.4-clpyrrol-2- yl.hutvn-6-chloro-pyridor2'.3':4.51thienor3.2-d1pyrimidine-2.4riH.3H)-dione dihydrochloride The product from Example 4A (0.27g, 1.0 mmol) and metiiyl 3-amino-7-chloro- thieno[3,2-b]pyridine-2-carboxylate were treated as described in Example IF to yield 0.12g (24%) of the title compound: m.p. 265-267°; l H NMR (300 MHz, CDCl3(free base)) δ 8.63 (d, IH), 7.51 (d, IH), 7.08 (t, IH), 6.48 (d, IH), 6.38 (d, IH), 4.93 (dd, IH), 4.02-4.18 (m, 3H), 3.99 (m, IH), 3.38 (t, IH), 2.88-3.12 (m, 5H), 2.45 (m, IH), 1.8 (m, 4H); MS (DCI/NH3) m/e 513(M+H)+; Analysis calc'd for C 2 5H 2 5N 4 0 4 SC1-2HC1: C, 51.25; H, 4.64; N, 9.56; found: C, 51.28; H, 4.96; N, 9.45. Example 6 3-r4-((3aR.9bS)-trαn.γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdiO-F ll-benzopyranor3.4-clpyrrol-2- yl)hutyll-8-chloro-pyridor2'.3':4.51thienor3.2-d)pyrimidine-2.4(lH.3H)-dione dihydrochloride The product from Example 4A (0.27g, 1.0 mmol) and methyl 3-amino-5-chloro- thieno[3,2-b]pyridine-2-carboxylate were treated as described in Example IF to yield 0.10 g (19%) of the title compound: m.p. >250°; *H NMR (300 MHz, CDCl 3 (free base)) δ 8.1 (d, IH), 7.41 (d, IH), 7.05 (t, IH), 6.48 (d, IH), 6.35 (d, IH), 4.57 (dd, IH), 4.11 (m, 3H), 3.95 (m, IH), 3.73 (s, 3H), 3.37 (m, 2H), 2.9-3.1 (m, 4H), 2.48 (m, IH), 1.8 (m, 4H); MS (DCI/NH3) m/e 513(M+H)+; Analysis calc'd for C25H25CIN4O4S 2HCI: C, 51.25; H, 4.64; N, 9.56; found: C, 51.22; H, 4.77; N, 9.32. Example 7 3-r4-f ( 3aR.9bSVtrα«.γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-c1pyrrol-2- yl.butyl1-8-methoxy-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3m-dione hydrochloride Example 7A 3-Amino-5-methoxy-thienor3.2-b.pyridine-2-carboxylate A solution of 3-amino-5-chloro-thieno[3,2-b]pyridine-2-carboxylate, (5g, 21 mmol) and sodium medioxide (4.5 g, 82 mmol) in MeOH (150 mL) were refluxed for 18 h. The reaction was concentrated and partitioned between EtOAc and NaHCU3 solution. The EtOAc layer was dried (MgSO4), filtered, concentrated, and chromatographed (5: 1 hex: EtOAc) to yield 2.5 g (51%) of the title compound: !H NMR (300 MHz, CDCI3) δ 3.80 (s, 3H), 4.02 (s, 3H), 6.05 (bs, 2H), 6.89 (d, IH), 7.88 (d, IH); MS (DCI NH3) m/e 239 (M+H)+. Example 7B 3-r4-(('3aR.9bS)-trαm-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-clpyrrol-2- yl)butyl]-8-methoxy-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione hydrochloride To 0.10 g (0.42 mmol) of the product from Example 7 A, dissolved in lOmL of dry THF and cooled to 0° C was add 2.2 equiv. of triethylamine (0.142 ml), followed by 0.23 ml of 1.93M solution of phosgene in toluene. The reaction was stirred for 3 hr and then 0.10 g (0.36 mmol) of the product from Example 4A was added. The reaction was stirred at room temperature overnight, and then partitioned between aq. NaHCU3 and CH2CI2. The organic phase was dried, concentrated, and dissolved in THF. Potassium t-butoxide (0.8 mmol in THF) was added. The reaction was stirred at room temperature for 2 hours, and then partitioned between aq. NaHCO3 and CH2CI2. After chromatographic purification and conversion to die hydrochloride salt, 0.09 g (48%) of the title compound was isolated:, m.p. 238-240°; *H NMR (300 MHz, CDCl 3 (free base)) δ 8.06 (d, IH), 7.05 (t, IH), 6.9 (d, IH), 6.48 (d, IH), 6.39 (d, IH), 4.45 (dd, IH), 4.12 (t, IH), 4.03 (s, 3H), 4.02 (m, IH), 3.76 (s, 3H), 3.59 (q, IH), 2.96 (q, IH), 2.78 (m, 4H), 2.56 (m, IH), 2.31 (m, IH), 1.79 (m, 2H), 1.63 (m, 2H); MS (DCI/NH3) m/e 509(M+H)+; Analysis calc'd for C26H28N4O 5 S-HC10.5H 2 O: C, 56.36; H, 5.46; N, 10.11; found: C, 56.56; H, 5.41; N, 9.97. Example 8 3-r4-f( ' 3aR.9bS)-trα^-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-c1pyrrol-2- yl.butvn-6-methoxy-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4πH.3HVdione dihydrochloride Example 8A 3-Amino-7-methoxy-thienor3.2-b.pyridine-2-carboxylate Following the procedure described in Example 7A, 3-amino-7-chloro-thieno[3,2- b]pyridine-2-carboxylate (2.0 g, 8.2 mmol) provided 1.1 g (56 %) of the title compound after chromatography with 1:1 hex:EtOAc: l H NMR (300 MHz, CDC1 3 ) δ 3.92 (s, 3H), 4.05 (s, 3H), 6.18 (bs, 2H), 6.81 (d, 2H), 8.52 (d, 2H); MS (DCI/NH3) m/e 239 (M+H)+. Example 8B 3-r4-(f3aR.9bS)-tr( y-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-rn-benzopyranor3.4-clpyrrol-2- yl)butyl1-6-methoxy-pyridor2'.3':4.51thienor3.2-d1ρyrimidine-2.4riH.3H)-dione dihydrochloride To 0.24 g (lmmol) of the product from Example 8A, dissolved in 10ml of dry THF and cooled to 0° C was added 2.2 equiv. of trietiiylamine (0.37ml), followed by 0.6ml of 1.93M solution of phosgene in toluene. The reaction was stirred for 3 hr and then 0.276 g (1.00 mmol) of the product from Example 4A was added. The reaction was stirred at room temperature overnight, and then partitioned between aq. NaHCU3 and CH2CI2. The organic phase was dried, concentrated, and dissolved in THF. Potassium t-butoxide (1 mmol in THF) was added. The reaction was stirred at room temperature for 2 hours, and then partitioned between aq. NaHCO3 and CH2CI2. After chromatographic purification and conversion to the dihydrochloride salt, 0.26g (49%) of the title compound was isolated: m.p. 191-193°; l H NMR (300 MHz, CDCl 3 (free base)) δ 8.63 (d, IH), 7.1 (t, IH), 6.92 (d, IH), 6.5 (d, IH), 6.4 (d, IH), 4.51 (dd, IH), 4.15 (m, 6H), 3.78 (s, 3H), 3.6 (m, IH), 3.0-3.3 (m, 6H), 2.52 (m, IH), 1.85 (m, 4H); MS (DCI/NH3) /e 509(M+H)+; Analysis calc'd for C26H28N4O5S 2HCI H2O: C, 52.09; H, 5.38; N, 9.34; found: C, 51.85; H, 5.47; N, 9.00. Example 9 3-r4-(f3aR.9hS)-/rfln.γ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-benzopyranor3.4-c1pyrro1-2- vnbutyll-8-phenyl-pyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4flH.3HVdione hydrochloride Example 9A 2-Chloro-3-cyano-5-phenvlpyrazine and 2-chloro-3-cyano-6-phenylpyrazine A mixture of 5- and 6- phenyl regioisomers of 2-hydroxy-3-carboxamidopyrazines (7.2g, 33.5 mmol) prepared by the method of R.G. Jones, J. Am, Chem. Soc. 71:78 (1949) was combined with phosphorous oxychloride (56 ml, 586 mmol) and triethylamine (9.3 mL, 67 mmol) and heated to reflux for 2 h. The mixture was evaporated to give a black oil which was extracted with ether (3 x 100 ml); the combined extracts were washed widi 300 ml of 10% Na2CO3, after which the aqueous layer was back-extracted with ether. The combined organic layers were decolorized widi activated carbon and filtered dirough Celite, then evaporated to give a white solid as a 60:40 mixture of the 5 and 6-phenyl isomers; mp: (mixture) 121-125 °C. *H NMR (300 MHz CDCI3) 5 7.52 (m, 5H major and minor), 8.02 (d, 2H (major), 8.11 (d, 2H (minor)), 9.0 (s, IH (major)), 9.05 (s, IH (minor)). MS (DCI/NH3) m/e 215 (M)+. Example 9B Methyl 7-amino-3-phenylthieno[ " 2.3-blpyrazine-6-carboxylate The product from Example 9A ( 1.20 g, 5.58 mmol) was treated sequentially with methyl thioglycolate (0.65 g, 6.14 mmol), and sodium methoxide (0.60 g, 11.2 mmol) in anhydrous DMF (5 ml) and die reaction was stirred at 25° for lh. The reaction mixture was dUuted widi water, the product collected by filtration and purified by column chromatography on silica gel eluting with CH2CI2 to yield 0.80 g (first eluting isomer) (47%) of the title compound as a yellow solid: J H NMR (300 MHz, CDCI3) 5 3.75 (s, 3H), 6.25 (br s, 2H), 7.53 (m, 3H), 8.09 (d, 2H), 9.09 (s, IH). MS (DCI/NH 3) m/e 286 (M+H) + . Example 9C 3-r4-f(3aR.9hSVtrfl«.y-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopvranor3.4-c1pyrrol-2- ynbutyl1-8-phenyl-pyrazinor2'.3':4.51thienor3.2-d1pyrimidine-2.4(lH.3HVdione hydrochloride The product from Example 4A (0.10 g, 0.42 mmol) and the product from Example 9B (0.14 g, 0.43 mmol) were treated as described in Example IF to yield 0.03 g (13%) of the title compound: m.p. >250°; *H NMR (300 MHz, CDCl 3 (free base)) δ 9.18 (s, IH), 8.11 (m, 2H), 7.6 (m, 3H), 7.1 (t, IH), 6.5 (d, IH), 6.38 (d, IH), 4.5 (dd, IH), 4.18 (m, 3H), 4.1 (m, IH), 3.8 (s, 3H), 3.18 (m, 6H), 2.5 (m, IH), 1.7-1.9 (m, 4H); MS (DCI/NH3) m/e 556(M+H)+; Analysis calc'd for C3oH29N 5 O4S HCl-2H 2 0: C, 57.36; H, 5.46; N, 11.15; found: C, 57.40; H, 5.27; N, 10.79. Example 9D Alternative Synthesis of Methyl 7-amino-3-phenvlthienor2.3-hlpvrazine-6-carhoxvlate To a flask was charged phenylglyoxime, 30 (44g, 0.3mol) and aminomalononitrile tosylate salt, 31 (75g, 0.3mol) and 518mL isopropanol. This was stirred at ambient temperature for 2 days. The reaction was then cooled to 0°C for 4 hours, and the soUd collected by filtration. The product was washed with 400mL cold isopropanol and dried in the oven at 50°C for 14hrs to give 60g (95% yield) of the pyrazine (32): NMR (300 MHz, DMSO d 6 ) δ 9.18 (s, IH), 8.08 (br s, 2H), 7.99-7.92 (m, 2H), 7.52 7.40 (m, 3H); ^CNMR (75.5 MHz, DMSO-d 6 ) δl49.6,142.2,134.2, 131.3, 129.3, 128.8,125.7, 1 15.2,111.1. To a flask was charged compound 32 (60g, O.28mol) and 230mL (1.34mol) triethyl phosphite. This was heated to 100°C for 7.5 hours, The solution was then cooled to ambient temperature and quenched with 480mL water. The slurry was stirred for 12 hours and filtered. The filtercake was washed widi 200mL of 10% ethanolic water and dried in a vacuum oven at 40°C for 24 hours to yield 53g (95% yield) of the compound (33); *HNMR (300 MHz, CDCI3) 8 8.96 (s, IH), 8.05-7.95 (m, 2H), 7.55-7.4 (m, 5H); 13 CNMR(75.5 MHz,CDCI 3 ) δ 155.9, 145.0, 140.9, 135.2,128.9, 128.6, 125.2, 116.1, 110.0; mp 181.5°C. To a flask was charged copper(II) bromide (67.3g, 0.3mol), DMF (300mL). This was heated to approx. 60°C. To the heated solution was added 46.5g (0.45mol) t-butylisonitrite. After stirring for approx. 2-5 minutes, compound 33 (58.85g, 0.3mol) was added portionwise. This was stirred at 60°C for 20 minutes. The contents were then cooled to approx. 15°C and transferred into 2.5L of 5% hydrochloric acid precooled to 5°C. This was stirred for 20 minutes and extracted with 600mL methylene chloride. The aqueous was extracted again with lOOmL methylene chloride and the organics combined. The organics were washed 4xlL water, and 300mL brine. lOOgr sodium sulfate and 50gr siUca were then charged to the organics. This was stirred and filtered. The filtercake was rinsed with methylene chloride to remove product The combined filtrate and washes were then distilled at not more tiian 40°C to a soUd. Drying at 30°C under vacuum gave 56.5g (72% yield) of the compound(34): »H NMR (300 MH 2 , DMSO-d 6 ) δ 5 8.95 (s, IH), 8.04-8.01 (m, 2H), 7.58-7.51 (m, 3H); ^CNMR (75.5 MHz, DMSO-dβ δ 151.8, 143.8, 140.4, 133.2, 132.2, 131.5, 129.5, 127.1, 114.8. To a flask was charged sodium carbonate (5.03g, 0.05mol), methylthioglycolate (5.03g, O.OSmol), and 400mL methanol. To this is added compound 34 (13.01 g, 0.05mol). This was stirred at ambient temperature for lh and then heated to 50°C for 1.5h before cooUng to o 4°C for 2h. The soUd was coUected by filtration and washed widi cold methanol (40mL) and dried to give 15.6g of the title compound impure. The solid was mixed with silica gel (29g) and washed with approx. 1.5L of methylene chloride. The organics were concentrated in-vacuo to give the title compound (35) (10.5 lg): lHNMR(300 MHz, DMSO-d 6 ) δ 9.42 (s, IH), 8.41- 8.35 (m, 2H), 7.6-7.5 (m, 3H), 7.2 (br s, 2H), 3.87 (s, 3H); mp 197-198°C. 5 Example 9E Alternative Synthesis of Methyl 7-amino-3-phenylthienor2.3-hlpyrazine-6-carhoxvlate To a slurry of distilled water (25mL), malononitrile (72g, 1 .09mol), and acetic acid (2.18g, 0.036mol) was added sodium nitrite (75.3g, l.O9mol) dissolved in water (300mL). 0 The reaction mixture was stirred for 2h and then slowly transferred into a solution of toluenesulfonyl chloride(200g, 1.05mol) dissolved in acetonitrile (463g) cooled to 12°C. After the addition was complete, die reaction mixture was slowly quenched into water (2.6L). The resultant slurry was stirred for at room temperature and then the solid formed was filtered, washed with water (2xlL) foUowed by heptane (200mL). The solids were dried under vacuum to give the compound (50).(242g, 92%) *HNMR (300 MHz, CDCI 3 ) d 7.80 (d, J=7 Hz), 7.35 (d, J=7 Hz), 2.41 (s 3H). Pyrrolidine (lOg, 0.14mole) and sodium sulfate (5g) were added to a flask and cooled to <0°C. Phenylacetaldehyde (2.4g, 0.02mol) was added slowly to the flask to keep temperature <2°C. The mixture was stirred at O/C for 1 hour. The reaction was filtered and the solids was washed witii 10ml heptane. The combined filtrates were distilled (<40°C) under vacuum to an oil. Heptane (30ml) was added and then distilled again to an oil. The final oU was mixed with dimethyfornamide (6ml) ant triethylamine (6.06g, 0.06moles). The mixture was then slowly added into a flask containing compound 50 (4.98g, 0.02moles) in DMF (20ml) at O°C±3°C. This reaction mixture was stirred at 0°C for 30 minutes and then thiophenol (2.4g, 0.022moles) was added. This mixture was stirred for 3 hours at ambient temperature before adding water (100 ml). This was stirred for 20 minutes at room temperature and the solid filtered. The filtercake was slurried with 50ml medianol and stirred for 20min and filtered. The solid was washed with lOml of methanol and dried to give a grayish solid of compound (5 l)(2.98g, 51%). ΗNMR (300 Mhz, CDCI 3 ) d8.9 (s, IH), 8.0-7.9 (m, 2H), 7.7-7.6 (m, 2H), 7.6-7.45 (m, 6H). To a solution of compound (51) (2.89g, 1 Ommol) in acetic anhydride (25mL) and chloroacetic acid (lOg, 106mmol) was added 30% aqueous hydrogen peroxide (lOg, 88mmol) at 0°C. The solution was stirred at room temperature for lh and tiien heated to 35 °C for 6h. The mixture was cooled to room temperature, dduted with water (25mL) and methanol (25mL), stirred at room temperature for 30min, and filtered. The filtercake was washed with 50% aqueous methanol (40mL) and dried to give compound (52).(2.9g, 90%): 1 HNMR(DMSO-d 6 ) δ 9.60 (IH, s), 8.21 ( 2H, dd, J=7.6, 1Hz), 8.07 ( 2H, dd, J=7.6, lHz),7.83 ( IH, dt, J=7.6,lHz),7.73(2H, m), 7.60(3H, m); 13 CNMR(DMSO-d 6 ); δl 13.96,126.13,128.04, 129.01,129.39,129.81,132.20,132.91,135.24,136.97,144.72,153.14, 154 21. A suspension of sulfone (52) (30mg, O.O9mmol), sodium carbonate (O. lg, 0.9mmol), and mediyl thioglycolate (20mg, O.19mmol) in methanol (3mL) was stirred at ambient temperature for 30min and then at 5O°C for 2h. After concentration in-vacuo, the residue was blended widi siUca (1.5g) and eluted with mediylene chloride (50mL). Concentration in- vacuo yielded the titie compound (15mg, 58%). Example 10 3-r4-((3aR.9hSVtr^.y-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-clpyrrol-2- yl.hutvn-8-chloro-pyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione hydrochloride Example 10A 2-Chloro-3-cyano-pyrazine-4-oxide 2-Chloro-3-cyanopyrazine (5.00 g, 35.94 mmol) was dissolved in 35 ml concentrated H2SO4 under nitrogen and cooled to 0 °C. To tiiis was added 11.65 g (43.95 mmol) K2S2O8 portionwise. The flask was fitted widi a CaCl2 drying tube, d e reaction mixture allowed to warm to rt and stir for 24 h. After partitioning between CHCI3 and ice water, the separated aqueous phase was extracted with CHCI3. The combined organics were washed with water, saturated NaHCθ3, brine and dried over MgSθ4. Concentration gave 2.01 g (36%) of the title compound as an off-white solid. *H NMR (300 MHz, CDCI3) δ 8.12 (d, IH), 8.38 (d, IH). MS (DCI/NH3) m/e 173 (M+NH4H. Example 10B Ethyl-7-aminothienor2.3-b|pyrazine-6-carboxylate-l-oxide The compound resulting from Example 10A (2.90 g, 18.64 mmol) was dissolved in 100 ml DMF under nitrogen and treated with ethyl thioglycolate (2.24 g, 18.64 mmol). After cooUng the solution to 0 °C, it was treated with solid NaOEt (2.54 g, 37.29 mmol) allowed to warm to rt and then stirred for 13 h. The reaction mixture was partitioned between ethyl acetate and brine and the layers separated. After extracting the aqueous phase with ethyl acetate, the combined organics were washed with water, brine and dried over MgSO4. Concentration gave a yellow soUd that was purified by column chromatography on silica gel eluting with 2: 1 then 1:1 hexanes:edιyl acetate to yield 3.50 g (78%) of die title compound as a yellow sotid: mp: 126-127° C; H NMR (300 MHz, CDC1 3 ) δ 1.40 (t, 3H), 4.38 (q, 2H), 7.25 (br s, 2H), 8.02 (d, IH), 8.41 (d, IH); MS (DCI/NH3) m/e 240 (M+H) + , 257 (M+NfL ÷; Analysis calc'd. for C9H9N3O3S: C, 45.18; H, 3.79; N, 17.56; Found: C, 44.94; H, 3.77; N, 17.47. Example IOC Ethyl-7-amino-2-chloro-thieno| " 2.3-b1pyrazine-6-carboxylate The compound resulting from Example 88B (0.88 g, 3.68 mmol) was dissolved in 50 ml POCI3 under nitrogen and heated to 95 °C for 3 h. The reaction mixture was concentrated and partitioned between etiiyl acetate and water. After extracting the aqueous phase with ethyl acetate, the combined organics were washed with water, saturated NaHCO3, brine and dried over Na2SO4. Concentration gave a two component mixture that was separated by column chromatography on sUica gel using a gradient elution from 10: 1 to 1 : 1 hexanes:ethyl acetate to give 0.56 g (59%) of the title compound: *H NMR (300 MHz, CDCI3) δ 1.41 (t, 3H), 4.40 (q, 2H), 6.11 (br s, 2H), 8.60 (s, IH); MS (DCI/NH3) m/e 258 (M+H) + , 275 (M+NH4)+. Example 10D 3-r4-((3aR.9hS .-trα/tγ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4-clpyrrol-2- ynhutyll-8-chloro-pyrazinor2'.3':4.51thienor3.2-dlpvrimidine-2.4riH.3HVdione hydrochloride The product resulting from Example 4A (0.25 g, 0.95 mmol) and die product from Example 10C (0.25 g, 1.1 mmol) were treated as described in Example IF to yield 0.15 g (29%) of the title compound: m.p. 266-267°; H NMR (300 MHz, CDCI3 (free base)) δ 8.7 (d, IH), 7.53 (d, IH), 7.1 (t, IH), 6.5 (d, IH), 6.4 (d, IH), 4.51 (dd, IH), 4.14 (t, 2H), 3.78 (s, 3H), 3.68 (m, IH), 3.55 (m, IH), 3.02-3.32 (m, 5H), 2.58 (m, 2H), 1.85 (m, 4H); MS (DCI/NH3) m/e 514(M+H)+; Analysis calc'd for C25H25CIN4O4S HCI 1.5H 2 O: C, 52.09; H, 5.07; N, 9.72; found: C, 52.21; H, 4.87; N, 9.60. Example 11 3-r4-rr3 a R.9hS .-tr_mv-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-rn-henzopyranor3.4-c1pyrrol-2- ynhutyll-l-(2-MethoxyethylVpyrazinor2'.3':4.51thienor3.2-d1pyrimidine-2.4(lH.3HVdione hydrochloride Example 11A Ethyl 7-rN-( ' 2-methoxyethyl.amino)thienor2.3-blpyrazine-6-carboxylate Ethyl 7-amino-thieno[2,3-b]pyrazine-6-carboxylate ( 1.0 g g, 4.48 mmol) prepared by the method of SchneUer and Clough, J. Het. Chem., 12: 513 (1975), was treated with potassium bis(trimethylsUyl)amide (0.5 M in toluene, 8.96 ml) in 15 ml THF at -70° C, and allowed to warm to room temperature. 2-Bromoethyl methyl ether (0.454 ml, 4.70 mmol) was added, and the reaction was stirred under N2 at 60° C overnight. The mixture was cooled and evaporated ,tiιen purified by column chromatography on sUica gel eluting with 1:9 ethyl acetate:hexanes to yield 0.640 g (51%) of the title compound as a yellow soUd: H NMR (300 MHz, DMSO-d6) d 1.32 (t, 3H), 3.3 (s, 3H), 3.56 (t, 2H), 4.25 (q, 2H), 4.32 ( t, 2H), 7.70 (br t, IH), 8.76 (s, IH), 8.77 (s, IH); MS (DCI/NH3) m/e 282 (M+H)+. Example 11B Ethyl 7-rN-(2-methoxyethyI)-N-chlorocarbamoylamino)thienor2.3-blpyrazine-6-carboxylate The product from Example 11 A (0.620 g, 2.20 mmol) was reacted with phosgene (1.93M in toluene, 3.41 ml, 6.6 mmol) and triethylamine (0.767 ml, 5.5 mmol) to yield the title compound (0.582 g, 81%) as a yellow oil: *H NMR (300 MHz DMSO-d6) d 1.31 (t, 3H), 3.3 (s, 3H), 3.56 (t, 2H), 4.23 (q, 2H), 4.3 (q, 2H), 8.78 (2 singlets, 2H); MS (DCI/NH3) 344 (M+H)+. Example 11C 3-r4-rf3aR.9hS .-trαn.γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-m-henzopyranor3.4-c1pyrrol-2- vnhutyl1-l-( ' 2-MethoxyethylVpyrazinor2'.3':4.51thienor3.2-d1pyrimidine-2.4π H.3HVdione hydrochloride The product from Example 4A (0.25g, 0.95mmol) was refluxed overnight with 0.1ml of triethylamine and 0.27g (0.82 mmol) of the product from Example 1 IB. After workup and chromatography, 0.3g (68%) of the title compound was isolated as its free base. The product was converted to its HCl-salt and recrystatized from ethanol/ether to yield the titie compound: m.p. 200-202°; Η NMR (300 MHz, CDCl (free base)) δ 8.78 (d, IH), 8.7 (d, IH), 7.1 (t, IH), 6.5 (d, IH), 6.4 (d, IH), 5.12 (t, 2H,), 4.5 (dd, IH), 4.05-4.2 (m, 4H), 3.8 (m, 5H), 3.5 (m, IH), 3.12 (m, 5H), 2.5 (m, IH), 1.85 (m, 4H); MS (DCI/NH3) m/e 538(M+H) + ; Analysis calc'd for C27H31N5O5S HCI O.75H2O: C, 55.19; H, 5.75; N, 11.92; found: C, 55.19; H, 5.49; N, 11.88. Example 12 3-r4-((3aR.9bS -frfln.y-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4-clpyrrol-2- yl butyl1-pyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H.-dione dihydrochloride Ethyl 7-amino-thieno[2,3-b]pyrazine-6-carboxylate ( 0.32 g, 1.35 mmol) prepared by the method of Schneller and Clough, J. Het. Chem., 12: 513 (1975) and the product from Example 4A (0.31 g, 1.13 mmol) were treated as described in Example IF to yield 0.28 g of the title compound as its free base. The product was converted to its HCl salt and recrystalUzed from ethanol/ether to yield the titie compound: m.p. >250°; ! H NMR (300 MHz, DMSO- d 6 (free base)) δ 8.98 (d, IH), 8.89 (d, IH), 7.11 (t, IH), 6.52 (d, IH), 6.45 (d, IH), 4.5 (dd, IH), 4.2 (m, IH), 4.1 (m, IH), 3.92 (m, 2H), 3.73 (s, 3H), 3.0 (m, IH), 2.6 (m, 5H), 2.3 (m, IH), 1.8 (m, 4H); MS (DCI/NH3) m/e 480(M+H) + ; Analysis calc'd for C24H25N5O4S.2HCI.O.5H2O: C, 51.34; H, 5.03; N, 12.47; found: C, 51.34; H, 4.95; N, 12.32. S6 Example 13 3-r4-(r3aS.9hRVtrfln.γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-henzopyranor3.4-c1pyrrol-7- yl .hutvn-8-chloro-pyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4πH.3HVdion ( . hydrochloride The product from Example IOC (0.27 g, 1.0 mmol) and the product from Example 3E (0.22 g, 0.8 mmol) were treated as described in Example IF to yield 0.22 g (66%) of the titie compound: m.p. >270°; *H NMR (300 MHz, CDCl 3 (free base)) δ 8.61 (s, IH), 7.05 (t, IH), 6.48 (d, IH), 6.45 (d, IH), 4.6 (m, IH), 4.45 (dd, IH), 4.18 (m, 3H), 3.71 (s, 3H), 3.52 (m, IH), 3.3 (m, IH), 3.1 (m, 2H), 2.9 (m, 2H), 2.5 (m, IH), 1.8 (m, 4H); MS (DCI/NH3) m/e 514(M+H)+; Analysis calc'd for C24H24CIN5O4S HCI O.5H2O: C, 51.52; H, 4.68; N, 12.52; found: C, 51.89; H, 4.38; N, 12.17. Example 14 3-r4-(('3aS.9hRVtr v-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4-clpyrrol-2- yl.butyn-pyrazino 2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H')-dione dihydrochloride Etivyl 7-amino-thieno[2,3-b]pyrazine-6-carboxylate ( 0.24 g, 1.0 mmol) prepared by the method of Schneller and Clough, J. Het. Chem., 12: 513 (1975) and the product from Example 3E (0.22 g, 0.8 mmol) were treated as described in Example IF to yield 0.16 g (43%) of the title compound: m.p. 219-222°; *H NMR (300 MHz, CDCI3 (free base)) δ 8.62 (s, IH), 8.45 (s, IH), 7.05 (t, IH), 6.48 (d, IH), 6.4 (d, IH), 4.5 (dd, IH), 4.2 (m, IH), 4.1 (m, 3H), 3.72 (s, IH), 7.7 (m, IH), 3.3 (m, 2H), 3.2 (m, IH), 3.05 (m, 2H), 2.52 (m, IH), 1.8 (m, 4H); MS (DCI/NH3) m/e 480(M+H)+; Analysis calc'd for C24H25N5O4S 2HCI O.5H2O: C, 51.34; H, 4.96; N, 12.25; found: C, 51.45; H, 4.96; N, 12.25. Example 15 3-r4-(GaR.9bR)-d.γ-9-Methoxy-1.2.3.3a.4.9b-hexahydro-ril-henzopyranor3.4-clpyrrol-2- yl)butyll-pyrazino[2'.3':4.51thieno[ " 3.2-d]pyrimidine-2.4(lH.3H)-dione dihydrochloride Ethyl 7-amino-thieno[2,3-b]pyrazine-6-carboxylate ( 0.24 g, 1.0 mmol) prepared by the method of Schneller and Clough, J. Het. Chem., 12: 513 (1975) and the product from Example IE (0.2 g, 0.75 mmol) were treated as described in Example IF to yield 0.11 g (32%) of the title compound: m.p. 220-222°; l H NMR (300 MHz, CDCl 3 (free base)) δ 8.7 (d, IH), 8.6 (d, IH), 7.02 (t, IH), 6.4 (t, 2H), 4.1 (m, 2H), 3.7-4.0 (m, 4H), 3.7 (s, 3H), 3.52 (m, 2H), 2.6-2.9 (m, 4H), 1.6-1.82 (m, 4H); MS (DCI/NH3) m/e 480(M+H)+; Analysis calc'd for C24H25N5O4S 2HCI: C, 52.18; H, 4.93; N, 12.68; found: C, 52.56; H, 4.99; N, 12.64. Example 16 3-r4-ff3aR.9bR ) - -9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-clpyrrol-2- yl ) butyll-8-chloro-pyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione hydrochloride The product from Example 10 C (0.27 g, 1.0 mmol) and die product from Example IE (0.20 g, 0.73 mmol) were treated as described in Example IF to yield 0.29 g (77%) of the title compound: m.p. 220-222°; *H NMR (300 MHz, CDCl 3 (free base)) δ 8.68 (s, IH), 7.0 (t, IH), 6.48 (d, IH), 6.45 (d, IH), 4.28 (m, IH), 4.12 (m, 3H), 4.0 (m, 2H), 3.75 (s, 3H), 3.6 (m, IH), 3.08 (m, 3H), 2.9 (m, 2H), 1.75 (m, 4H); MS (DCI NH3) m/e 514(M+H)+; Analysis calc'd for C24H24CIN5O4S HCI O.75H2O: C, 51.11; H, 4.74; N, 12.42; found: C, 51.09; H, 4.75; N, 12.43. Example 17 3-r4-(r3aS.9bR)-trα -9-Methoxy-1.2.3.3a.4.9b-hexahvdro-πi-benzopyranor3.4-c1pyrrol-2- yl)butvn-6-methoxy-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione dihydrochloride The product from Example 8 A (0.24 g, 1.0 mmol) and the product from Example 3E (0.276 g, 1.0 mmol) were treated as described in Example IF to yield 0.26 g (51%) of the title compound: m.p. 173-174°; *H NMR (300 MHz, CDCl (free base)) δ 8.64 (d, IH), 7.08 (t, IH), 6.92 (d, IH), 6.5 (d, IH), 6.4 (d, IH), 6.5 (dd, IH), 4.5 (dd, IH), 4.12 (m, 8H), 3.76 (s, 3H), 3.02 (m, 4H), 2.45 (m, 2H), 1.82 (m, 4H); MS (DCI/NH3) m/e 509(M+H)+; Analysis calc'd for C 2 6H28N O 5 S-2HC10.25H 2 O: C, 60.86; H, 5.60; N, 10.92; found: C, 60.84; H, 5.41; N, 10.62. Example 18 3-r4-((3aR.9bR)-c^-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-clpyrrol-2- yl.butyll-6-methoxy-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4( ' lH.3H)-dione. dihydrochloride The product from Example 8A (0.30 g, 1.26 mmol) and the product from Example IE (0.345 g, 1.25 mmol) were treated as described in Example IF to yield 0.37 g (58%) of die titie compound: m.p. 204-206°; ! H NMR (300 MHz, CDCl3(free base)) δ 8.64 (d, IH), 7.05 (t, IH), 6.92 (d, IH), 6.51 (d, IH), 6.44 (d, IH), 4.0-4.18 ( m, 6H), 3.8 (s, 4H), 3.6 (m, IH), 3.44 (m, IH), 3.24 (m, IH), 2.6 (m, 3H), 2.3 (m, 2H), 1.78 (m, 2H), 1.64 (m, 2H); MS (DCI NH3) m/e 509(M+H)+; Analysis calc'd for C26H 2 8N O 5 S-2HCl-2H 2 O: C, 50.57; H, 5.55; N, 9.07; found: C, 50.59; H, 5.74; N, 9.05. Example 19 3-r4-((3aS.9bR)-tr n -9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-c1pyrrol-2- yl)butyll-6-chloro-pyridor2'.3':4.51thienor3.2-d1pyrimidine-2.4(lH.3H)-dione hydrochloride The product from Example 5 A (0.24 g, 1.0 mmol) and the product from Example 3E (0.27 g, 1.0 mmol) were treated as described in Example IF to yield 0.08 g (15%) of the title compound: m.p. 266-267°; *H NMR (300 MHz, CDCl (free base)) δ 8.7 (d, IH), 7.53 (d, IH), 7.1 (t, IH), 6.5 (d, IH), 6.4 (d, IH), 4.51 (dd, IH), 4.14 (t, 2H), 3.78 (s, 3H), 3.68 (m, IH), 3.55 (m, IH), 3.02-3.32 (m, 5H), 2.58 (m, 2H), 1.85 (m, 4H); MS (DCI/NH3) m/e 514(M+H) + ; Analysis calc'd for C25H 2 5ClN 4 O 4 S HC1 1.5H 2 O: C, 52.09; H, 5.07; N, 9.72; found: C, 52.21; H, 4.87; N, 9.60. Example 20 3-r4-(GaR.9bR)-c^-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-rn-benzopyranor3.4-c1pyrrol-2- yl)butyll-6-chloro-pyridor2'.3':4.51thienor3.2-d1pyrimidine-2.4(lH.3H)-dione hydrochloride The product from Example 5 A (0.24 g, 1.0 mmol) and the product from Example IE (0.27 g, 1.0 mmol) were treated as described in Example IF to yield 0.125 g (25%) of the title compound: m.p. 180-182°; H NMR (300 MHz, CDCl 3 (free base)) δ 8.63 (d, IH), 7.51 (d, IH), 7.05 (t, IH), 6.48 (d, IH), 6.42 (d, IH), 4.1 (t, 2H), 4.0 (dd, IH), 3.73 (m, IH), 3.7 (s, 3H), 3.48 (q, 2H), 3.38 (m, IH), 3.25 (m, IH), 2.7 (m, 3H), 2.5 (m, IH), 2.4 (m, IH), 1.78 (m, IH), 1.65 (m, IH); MS (DCI/NH3) m/e 513(M+H) + ; Analysis calc'd for C25H 25 C1N 4 O 4 S HC10.75H 2 O: C, 53.34; H, 4.92; N, 9.95; found: C, 53.42; H, 4.65; N, 9.55. Exam le 21 3-r4-r(3aS.9bRVtrα«.γ-9-Methoxy-I.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-clpy_τol-2- yl)butyll-ri1benzthienor3.2-d1pyrimidine-2.4πH.3H)-dione hydrochloride Methyl-3-amino-benzo[b]thiophene-2-carboxylate (0.24 g, 0.97 mmol) and the product from Example 3E (0.18 g, 0.6 mmol) were treated as described in Example IF to yield 0.22 g (77%) of the title compound: m.p. >250°; l U NMR (300 MHz, CDCl 3 (free base)) δ 8.28 (d, IH), 7.39 (d, IH), 7.56 (m, 2H), 7.04 (t, IH), 6.46 (d, IH), 6.38 (d, IH), 4.4 (dd, IH), 4.24 (t, 2H), 4.0 (t, IH), 3.71 (s, 3H), 3.65 (m, IH), 3.0 (t, IH), 2.81 (m, 4H), 2.58 (t, IH), 2.3 (m, IH), 1.88 (m, 2H); MS (DCI/NH3) m/e 478(M+H) + ; Analysis calc'd for C 6H27N 3 O 4 S HCl: C, 60.75; H, 5.49; N, 8.17; found: C, 60.65; H, 5.31; N, 8.03. Example 22 3-r4-((3aR.9bR -c .γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-clpyrrol-2- yl)butyll-P1benzthienor3.2-dlpyrimidine-2.4(lH.3H.-dione hydrochloride Methyl-3-amino-benzo[b]thiophene-2-carboxylate (0.13 g, 0.52 mmol) and the product from Example IE (0.10 g, 0.36 mmol) were treated as described in Example IF to yield 0.11 g (64%) of the title compound: m.p. 198-199°; *H NMR (300 MHz, CDCI3) δ 8.22 (d, IH), 8.4 (d, IH), 7.55 (m, 2H), 7.04 (t, IH), 6.5 (d, IH), 6.43 (d, IH), 4.22 (t, 2H), 4.0 (dd, IH), 3.78 (s, 3H), 3.72 (m, IH), 3.48 (m, IH), 3.39 (m, IH), 3.11 (m, IH), 2.55 (m, 3H), 2.2 (m, 2H), 1.86 (m, 2H), 1.69 (m, 2H); MS (DCI NH3) m/e 478(M+H) + ; Analysis calc'd for C 2 6H27N 3 O 4 S HCl: C, 60.75; H, 5.49; N, 8.17; found: C, 60.62; H, 5.27; N, 8.03. Example 23 3-r5-(r3aS.9bRVtrα«.γ-9-Methoxy-1.2.3.3a.4.9h-hexahydro-ril-benzopyranor3.4-c1pyrrol-2- yl)pentyll-[11benzthienor3.2-dlpyrimidine-2.4(lH.3H)-dione hydrochloride Example 23A (3aS.9bR)-tr_ γ-2-( ' 4-cyanobutyl)-9-Methoxy- 1.2.3.3a.4.9b-hexahydro-fl1-benzopyrano[3.4- clpyrrole The product from Example 3C (0.12 g, 0.6 mmol), 5-chlorovaleronitrile (0.08g, 0.69 mmol) and 1.0 mL ethyldiisopropylamine were heated to reflux in 5 mL acetonitrile for 6 h. Solvent was evaporated, and the product partitioned between ediyl acetate and water. The organic layer was dried, evaporated, and purified by silica gel column chromatography to yield 0.11 g(64%) of the title compound: X H NMR (300 MHz, CDC1 3) δ 7.05 (t, IH), 6.49(d,lH), 6.39(d,lH),4.46(dd,lH), 3.77(s,3H), 3.56(q,lH), 2.92(q,lH), 2.68-2.88(m,4H), 2.57(q,lH), 2.42(t,2H), 2.32(m,lH), 1.71(m,4H); MS (DCI/NH3) m/e 287(M+H) + Example 23B (3aS.9bR ) -trαnj-2- ( 5-aminopentyl ) -9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ri1- benzopyranor3.4-clpyrrole Lithium aluminum hydride (0.1 lg, 2.88mmol) was suspended in ether, and asolution of 0.13g (0.96mmol) of aluminum chloride in ether was added. To the reaction was then added a solution of the product from Example 23 A (O.llg, 0.38mmol). The reaction was stirred at 25° for 3 h, and then isolated (Fieser workup) to yield 0.10 g (90%) of the titie compound: l U NMR (300 MHz, CDCI3) δ 7.05 (t,lH), 6.49 (d,lH), 6.39 (dlH), 4.45 (dd,lH), 4.05 (q,lH), 3.77 (s,3H), 3.58 (q,lH), 2.93 (q,lH), 2.61-2.88 (m,6H), 2.56 (m,lH), 2.3 (m,lH), 1.5 (m2H), 1.48 (m,2H); MS (DCI/NH3) m/e 291(M+H)+: Example 23C 3-r5-((3aS.9bR)-trα^-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-clpyrrol-2- yl)pentyn-πibenzdιienor3.2-dlpyrimidine-2.4(lH.3H)-dione hydrochloride Methyl-3-amino-benzo[b]thiophene-2-carboxylate (0.10 g, 0.40 mmol) and the product from Example 23B (0.11 g, 0.38 mmol) were treated as described in Example IF to yield 0.11 g (60%) of the title compound: m.p. 196-198°; l U NMR (300 MHz, CDCl 3 (free base)) δ 8.22 (d, IH), 7.89 (d, IH), 7.53 (m, 2H), 7.03 (t, IH), 6.48 (d, IH), 6.38 (d, IH), 4.41 (dd, IH), 4.21 (t, 2H), 4.02 (dd, IH), 3.71 (s, 3H), 3.56 (m, IH), 2.92 (m, IH), 2.63-2.86 (m, 3H), 2.52 (m, IH), 2.3 (m, IH), 1.87 (m, 2H), 1.62 (m, 2H), 1.55 (m, 2H), 1.4 (m, IH); MS (DCI/NH3) m/e 492(M+H) + ; Analysis calc'd for C27H29N 3 O 4 S HCl H 2 O: C, 59.39: H, 5.91; N, 7.69; found: C, 59.83; H, 5.71; N, 7.48. Example 24 3-r5-((3aR.9bR_-c^-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-clpyrrol-2- yl)pentyll-rnbenzthienor3.2-d1pyrimidine-2.4(lH.3H)-dione hydrochloride Example 24A (3aR.9bR)-c .r-2-( ' 4-cyanohutvn-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4- clpyrrole The product from Example 1C (0.10 g, 0.5 mmol), 5-chlorovaleronitrile (0.067g, 0.57 mmol) and 1.0 mL ethyldiisopropylamine were heated to reflux in 5 mL acetonitrile for 6 h. Solvent was evaporated, and die product partitioned between ethyl acetate and water. The organic layer was dried, evaporated, and purified by sUica gel column chromatography to yield 0.08 g(58%) of the title compound: *H NMR (300 MHz, CDC1 3 ) δ 7.08 (t, IH), 6.51 (d,lH), 6.45 (d,lH), 4.04 (dd,lH), 3.82 (s,3H), 3.78 (m,lH), 3.4 (m,2H), 3.06 (q,lH), 2.6 (m,lH) s 2.48 (q,2H), 2.39 (t,2H), 2.25 (m,2H), 1.71 (m,4H); MS (DCI/NH3) m/e 287(M+H)+ Example 24B (3aR.9bR -c/.γ-2-('5-aminopentylV9-Methoxy-1.2.3.3a.4.9b-hexahvdro-fll-benzopyranor3.4- cjpyrrole Lithium aluminum hydride (0.10g, 2.63 mmol) was suspended in ether, and a solution of 0.11 g (0.82 mmol) of aluminum chloride in ether was added. To the reaction was then added a solution of die product from Example 24A (0.08g, 0.28mmol). The reaction was stirred at 25° for 3 h, and tiien isolated (Fieser workup) to yield 0.07 g (86%) of the title compound: *H NMR (300 MHz, CDCI3) δ 7.08 (t,lH), 6.51 (d,lH), 6.45 (dlH), 4.03 (dd,lH), 3.8 (s,3H), 3.78 (m.lH), 3.45 (m,2H), 3.12 (q,lH), 2.68 (t,2H), 2.6 (m,lH), 2.43 (m,2H), 2.18 (m,2H), 1.5 (m2H), 1.38 (m,2H); MS (DCI/NH3) m/e 291(M+H) + . Example 24C 3-r5-((3aR.9bR - γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-πi-benzopyranor3.4-clpyrrol-2- yl.pentvn-rilbenzthienor3.2-dlpyrimidine-2.4riH.3H)-dione hydrochloride Methyl 3-amino-benzo[b]thiophene-2-carboxylate (0.10 g, 0.40 mmol) and the product from Example 24B (0.07 g, 0.24 mmol) were treated as described in Example IF to yield 0.08 g (69%) of the title compound: m.p. 128-130°; U NMR (300 MHz, CDCl 3 (free base)) δ 8.12 (d, IH), 7.72 (d, IH), 7.4 (m, 2H), 7.08 (t, IH), 6.52 (d, IH), 6.47 (d, IH), 4.4 (m, 2H), 4.3 (m, IH), 4.04 (dd, IH), 3.7 (s, 3H), 3.5 (m, IH), 3.32 (m, 2H), 3.2 (m, IH), 2.7 (m, IH), 2.52 (m, 2H), 2.35 (m, 2H), 1.88 (m, IH), 1.62 (m, 4H); MS (DCI/NH3) m/e 492(M+H)+; Analysis calc'd for C27H29N 3 O 4 S HCl H 2 O: C, 59.39; H, 5.91; N, 7.69; found: C, 59.47; H, 5.94; N, 7.52. Example 25 3-r4-(f3aS.9hR)-trαn.γ-9-Methoxv-1.2.3.3a.4.9h-hexahvdro-πi-henzopyranor3.4-c1pyrrol-2- yl)butyll-8-chloro-pyridor2 , .3':4.51thienor3.2-d1pyrimidine-2.4π 3H.-dinne dihydrochloride Methyl 3-amino-5-chloro-thieno[3,2-b]pyridine-2-carboxylate, prepared as described in Example 6A (0.24 g, 1.0 mmol) and the product from Example 3E (0.20 g, 0.7 mmol) were treated as described in Example IF to yield 0.18 g (50%) of the title compound: m.p. >250°; !H NMR (300 MHz, CDCl 3 (free base)) δ 8.1 (d, IH), 7.21 (d, IH), 7.02 (t, IH), 6.48 (d, IH), 6.38 (d, IH), 4.56 (dd, IH), 4.1 (m, 2H), 3.88 (m, IH), 3.73 (s, 3H), 3.3 (m, 2H), 2.85-3.12 (m, 4H), 2.44 (m, 2H), 1.8 (m, 4H); MS (DCI/NH3) m/e 513(M+H)+; Analysis calc'd for C 2 5H 2 5ClN 4 O 4 S-2HCl: C, 51.25; H, 4.64; N, 9.56; found: C, 51.04; H, 4.58; N, 9.27. Example 26 3-r4-r(3aS.9hRVtr < γ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-πi-henzopyranor3.4-clpyrrol-2- yl.butyll-8-methoxy-pyrido[2'.3':4.51thienor3.2-dlpyrimidine-2.4riH.3HVdione hydrochloride Methyl 3-amino-5-methoxy-thieno[3,2-b]pyridine-2-carboxylate, prepared as described in Example 7A (0.20 g, 0.84 mmol) and the product from Example 3E (0.23 g, 0.84 mmol) were treated as described in Example IF to yield 0.30 g (70%) of the title compound: m.p. >250°; J H NMR (300 MHz, CDCl (free base)) δ 8.06 (d, IH), 7.05 (t, IH), 6.9 (d, IH), 6.48 (d, IH), 6.39 (d, IH), 4.45 (dd, IH), 4.12 (t, IH), 4.03 (s, 3H), 4.02 (m, IH), 3.76 (s, 3H), 3.59 (q, IH), 2.96 (q, IH), 2.78 (m, 4H); MS (DCI/NH3) m/e 509(M+H)+; Analysis calc'd for C26H28N 4 O 5 S-HClO.25H 2 O: C, 56.82; H, 5.41; N, 10.19; found: C, 56.68; H, 5.19; N, 10.09. Example 27 3-r4-((3aS.9bRVtrαn.γ-9-Methoxy-1.2.3.3a.4.9h-hexahydro-πi-benzopyranor3.4-clpyrrol-2- yl.hutvn-7-methoxy-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione hydrochloride Example 27A 2-Cyano-3.5-dichloropyridine 3,5-Dichloropyridine-N-oxide (10.0 g, 61 mmol), trimethystiylcyanide (25 mL, 183 mmol) and triethylamine (17 mL, 122 mmol) combined in acetonitrile (60 mL) and heated to reflux for 6 hr. The solvent was evaporated and the residue was partitioned between diethyl ether and 5% aq. NaHCO3. The organic phase was dried (MgSO 4 ), evaporated, and the product purified by chromatography over siUca gel to yield 10.0 g (97%) of the title compound: *H NMR (300 MHz, CDC1 3 ) δ 7.92 (d, IH), 8.58 (d, IH). Example 27B 3-Chloro-2-cyano-5-methoxypyridine The product from Example 27A (0.865 g, 5.0 mmol) was dissolved in THF (10 mL) and 0.27 g NaOMe was added. After 3h and 25° C, the reaction was quenched in 5% aq. NaHCO3 solution and extracted with dietiiyl ether. The organic phase was dried, evaporated, and die residue purified by column chromatography, eluting with 70:30 hexanes:etiιyl acetate to yield 0.27 g (32%, second eluting component) of the title compound: *H NMR (300 MHz, CDCI3) δ 3.95 (s, 3H), 7.29 (d, IH), 8.28 (d, IH). Example 27C Methyl 3-amino-6-methoxy-thienor3.2-b1pyridine-2-carboxylate The product from Example 27B (0.168 g, 1.0 mmol) and methyl thioglycolate (0.09 mL, 1.0 mmol) were combined in DMF (2 mL). To the solution was added 0.054 g NaOMe. After 1 hr, and additional 0.07 g NaOMe was added. After an additional 1 hr, the reaction was quenched in sat. aq. NF iCl and extracted widi ethyl acetate. The organic phase was dried (MgSO 4 ), and evaporated to yield 0.17 g of the title compound: *H NMR (300 MHz, CDCI3) δ 3.90 (s, 3H), 3.93 (s, 3H), 6.15 (br s, 2H), 7.44 (d, IH), 8.36 (d, IH). Example 27D 3-r4-r(3aS.9bR.-trαn.γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-rn-henzopyranor3.4-c1pyrrol-2- yl.hutvn-7-methoxy-pyridor2 , .3':4.51thienor3.2-dlpvrimidine-2.4(lH.3HVdione hydrochloride The product from Example 27C (0.12 g, 0.50 mmol) and die product from Example 3E (0.15 g, 0.47 mmol) were treated as described in Example IF to yield 0.12 g (47%) of the title compound: m.p. 235-237°; l U NMR (300 MHz, CDCl 3 ((free base)) δ 8.45 (d, IH), 7.6 (d, IH), 7.05 (t, IH), 6.48 (d, IH), 6.38 (d, IH), 4.45 (dd, IH), 4.1 (t, 2H), 4.05 (m, IH), 3.98 (s, 3H), 3.78 (s, 3H), 3.72 (m, IH), 3.05 (m, IH), 2.85 (m, 4H), 2.65 (m, IH), 2.38 (m, IH), 1.8 (m, 2H), 1.7 (m, 2H); MS (DCI/NH3) m/e 509(M+H) + ; Analysis calc'd for C26H28N 4 O5S HCl H2O: C, 55.46; H, 5.55; N, 9.95; found: C, 55.22; H, 5.30; N, 9.75. Example 28 3-r4-r(3aR.9bR - ;γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-πi-benzopyranor3.4-clpyrrol-2- vDhutvn-pyridor3'.4':4.51thienor3.2-dlpyrimidine-2.4( ' lH.3HVdione dihydrochloride The product from Example IE (400 mg, 1.5 mmol), 3-amino-2- carbomethoxythieno[3,2-c]pyridine (.33 g, 1.6 mmol) (J. Heterocyclic Chem,, 24, 85 (1987)), E.3N (.50 mL, 3.6 mmol), and phosgene (0.82 mL 1.93 M solution in toluene, 1.6 mmol) were treated as described in Example IF to yield 0.38 g (55%) of the title compound: m.p. 207-210°; *H NMR (300 MHz, CDCI3 (free base)) δ 1.62-1.75 (m, 2H), 1.80-1.92 (m, 2H), 2.20-2.33 (m, 2H), 2.49-2.65 (m, 3H), 3.15 (bt, J=8 Hz, IH), 3.39 (q, J=8 Hz, IH), 3.50 (t s J=8 Hz, IH), 3.70-3.79 (m, IH), 3.75 (s, 3H), 3.98 (dd, J=4, 9 Hz, IH), 4.22 (t, J=7 Hz, 2H), 6.41 (dd, J=l, 8 Hz, IH), 6.47 (dd, J=l, 8 Hz, IH), 7.03 (t, J=8 Hz, IH), 7.82 (dd, J=l, 5 Hz, IH), 8.65 (d, J=5 Hz, IH), 9.55 (s, IH); MS (DCKNH3)) m/e 479 (M+H)+; Analysis calc'd for C25H26N4θ4S » (HCl)2*(H2θ)o.75: C, 53.15; H, 5.26; N, 9.22; found: C, 53.37; H, 5.11; N, 9.74. Example 29 3-f4-rr3aR.9hRVe/.γ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-benzopyranor3.4-clpyrrol-2- vnbutyll-pyridor4'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione dihydrochloride The product from Example IE (400 mg, 1.5 mmol), 3-amino-2- carbomethoxythieno[2,3-c]pyridine (.33 g, 1.6 mmol) (J. Heterocyclic Chem,, 24, 85 (1987)), E_3N (.50 mL, 3.6 mmol), and phosgene (0.82 mL 1.93 M solution in toluene, 1.6 mmol) were treated as described in Example IF to yield 0.50 g (72%) of the titie compound: m.p. 212-214°; *H NMR (300 MHz, CDCI3 (free base)) δ 1.61-1.76 (m, 2H), 1.81-1.93 (m, 2H), 2.21-2.31 (m, 2H), 2.50-2.67 (m, 3H), 3.15 (dd, J=7, 9 Hz, IH), 3.36-3.55 (m, 2H), 3.73- 3.82 (m, IH), 3.78 (s, 3H), 4.00 (dd, J=5, 11 Hz, IH), 4.23 (t, J=7 Hz, 2H), 6.42 (d, J=8 Hz, IH), 6.48 (d, J=8 Hz, IH), 7.04 (t, J=8 Hz, IH), 8.12 (d, J=6 Hz, IH), 8.71 (d, J=6 Hz, IH), 9.24 (s, IH); MS (DCI(NH3)) m/e 479 (M+H)+; Analysis calc'd for C25H26N4θ4S « (HCl)2: C, 54 .45; H, 5.12; N, 10.16; found: C, 54.05; H, 5.24; N, 10.05. Example 30 3-r4-((3aR.9hRVc .γ-9-Methoxy-1.2.3.3a.4.9h-hexahydro-πi-henzopyranor3.4-clpyrrol-2- yl)butyl1-8-methoxy-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione hydrochloride The product from Example 7 A (0.30 g, 1.26 mmol) and the product from Example IE (0.35 g, 1.26 mmol) were treated as described in Example IF to yield 0.37 g (58%) of the title compound: m.p. 195-197°; 1H NMR (300 MHz, CDCl3(free base)) δ 8.3 (d, IH), 7.07 (t, IH), 6.98 (d, IH), 6.52 (d, IH), 6.46 (d, IH), 4.05 (t, 2H), 4.03 (m, IH), 4.02 (s, 3H), 3.83 (m, IH), 3.81 (s, 3H), 3.5 (m, 2H), 3.25 (m, IH), 2.65 (m, 3H), 2.3 (m, 2H), 1.78 (m, 2H), 1.58 (m, 2H); MS (DCI/NH3) m/e 509(M+H)+; Analysis calc'd for C26H28 4O5S-HC1-H2O: C, 55.46; H, 5.55; N, 9.95; found: C, 55.40; H, 5.62; N, 9.58. Example 31 3-[4-((3aR.9bR)-ct_-9-Methoxy-1.2.3.3a.4.9b-hexahydro-[n-benzopyranor3.4-c1pyrrol-2- yl)butyll-8-methoxy-pyrazinor2'.3':4.51thienor3.2-d1pyrimidine-2.4(lH.3H)-dione hydrochloride Example 31 A Ethyl 7-amino-2-methxoy-thienor2.3-hlpvrazine-6-carhoxylate The compound from Example IOC (0.700 g, 2.72 mmol) was dissolved in 75 ml MeOH, treated with solid NaOMe (1.47 g, 27.2 mmol) and die resulting solution refluxed for 12h. The reaction mixture was partitioned between saturated NH4CI and CHCI3. After extracting the aqueous phase with CHCI3, the combined organics were washed witii water then brine and dried over Na2SO4. Concentration gave 0.500 g (77%) pure titie compound as a yellow solid: mp: 181-182 °C; l H NMR (300 MHz, CDCI3) δ 3.92 (s, 3H), 4.05 (s, 3H), 6.02 (br s, 2H), 8.30 (s, IH); MS (DCI NH3) m/e 240 (M+H)+ 257 (M+NH4)+. Analysis calc'd. for C9H9N3O3S: C, 45.18; H, 3.79; N, 17.56; Found: C, 45.25; H, 3.48; N, 17.41. Example 3 IB 3-r4- (( 3aR.9bRV .γ-9-Methoxv-1.2.3.3a.4.9h-hexahvdro-m-henzopyranor3.4-c1pyrrol-2- vDbutvll-8-methoxv-nvrazinor2'.3':4.51thienor3.2-d1nvrimidine-2.4flH.3HVdione hydrochloride The product from Example 31 A (0.30 g, 1.26 mmol) and die product from Example IE (0.35 g, 1.26 mmol) were treated as described in Example IF to yield 0.33 g (52%) of the title compound: m.p. 182-184°; *H NMR (300 MHz, DMSO-d6(free base)) δ 8.58 (s, IH), 7.13 (t, IH), 6.61 (d, IH), 6.52 (d, IH), 4.1 (m, IH), 4.08 (s, 3H), 3.96 (t, 2H), 3.85 (m, IH), 3.8 (s, 3H), 3.42 (m, 2H), 3.1 (m, IH), 2.85 (m, 3H), 2.75 (m, 2H), 1.68 (m, 4H); MS (DCI/NH3) m/e 510(M+H)+; Analysis calc'd for C25H27N5O5S HCI 2H2O: C, 51.59; H, 5.54; N, 12.03; found: C, 51.67; H, 5.43; N, 11.84. Example 32 3-r4-((3aR.9bR)-c .γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-πi-henzopyranor3.4-c1pyrrol-2- yl butyll-7-chloro-pyridor3'.2':4.51thienor3.2-dlpyrimidine-2.4( ' lH.3HVdione hydrochloride Example 32A Methyl 3-amino-5-chloro-thienor2.3-blpyridine-2-carboxylate 3-Cyano-2,6-dichloropyridine (5.19 g, 30 mmol) and 2.7 mL (30 mmol) methyl thioglycolate were combined in DMF (25 mL) and die solution was cooled to 0° C. To die reaction was added KOH (3.0 g, 54 mmol) in 12 mL H2O. After 1.5 h at 0° C the reaction was diluted with H2O (50 mL) and the precipitate coUected. The product was recrystallized from ethyl acetate/hexane to yield 1.49 g (20%) of the title compound: 1H NMR (300 MHz, CDCI3) δ 3.92 (s, 3H), 5.90 (br s, 2H), 7.33 (d, IH), 7.87 (d, IH). Example 32B 3-r4-((3aR.9bRV .γ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-πi-benzopyranor3.4-clpyrrol-2- yl)butyll-7-chloro-pyridor3'.2':4.51thienor3.2-dlpyrimidine-2.4(lH.3H -dione hydrochloride The product from Example IE (0.414 g, 1.5 mmol) and the product from Example 32A (0.382 g, 1.57 mmol) were treated as described in Example IF to yield 0.30 g (25%) of the title compound.: m.p. 201-205°; *H NMR (300 MHz, CDCI3) δ 1.6-1.9 (m, 4H), 2.2-2.44 (m, 2H), 2.5-5.8 (m, 4H), 3.1-3.9 (m, 4H), 3.78 (s, 3H), 4.02 (dd, IH), 4.18 (t, 2H), 6.42 (d, IH), 6.49 (d, IH), 7.05 (t, IH), 7.49 (d, IH), 8.49 (d, IH); MS (DCI/NH3) m/e 513 (515 (M+H)+); Analysis calc'd for C25H26CI2N4O4S H2O: C, 52.91; H, 4.97; N, 9.87; Cl, 12.49; found: C, 53.17; H, 4.87; N, 9.52; Cl, 12.43. Example 33 3-r4-rr3aR.9hRV .v-9-Methoxy- 1.2.3 ■3a.4.9h-hexahvdro-m-henzopyranor3.4-clpyrrol-2- yl)butvn-7-methoxy-pyridor3'.2':4.51thienor3.2-d1pyrimidine-2.4flH.3HVdione hydrochloride Example 33 A Metiiyl 3-amino-5-methoxy-thienof2.3-blpyridine-2-carboxylate Sodium metal (0.46 g, 20 mmol) was added to methanol (20 mL) and allowed to react until metalhc sodium was consumed. To the solution was added the product from Example 32A (0.485 g, 2.0 mmol) and the reaction was heated to reflux for 2h. The reaction was quenched in sat. aq. NH4CI and extracted with ethyl acetate. The organic phase was dried (MgSO4) and evaporated to yield 0.410 g (86%) of the title compound: 1H NMR (300 MHz, CDCI3) δ 3.88 (s, 3H), 4.02 (s, 3H), 6.74 (d, IH), 7.77 (d, IH). Example 33B 3-r4-rr3aR.9bRVe .γ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4-clpyrrol-2- yl)butyll-7-methoxy-pyridor3'.2':4.51thienor3.2-d1pyrimidine-2.4flH.3H)-dione hydrochloride The product from Example IE (0.414 g, 1.5 mmol) and the product from Example 33 A (0.375 g, 1.57 mmol) were treated as described in Example IF to yield 0.480 g (51%) of the title compound.: m.p. 210-14°; 1H NMR (300 MHz, CDCI3) δ 1.64-1.88 (m, 4H), 2.2-2.4 (m, 2H), 2.5-2.8 (m, 4H), 3.1-3.9 (m, 4H), 3.78 (s, 3H), 4.02 (dd, IH), 4.07 (s, 3H), 4.15 (t, 2H), 6.44 (d, IH), 6.53 (d, IH), 6.88 (d, IH), 7.07 (t, IH), 8.54 (d, IH); MS (DCI/NH3) m/e 509 (M+H)+; Analysis calc'd for C25H29C1 4O5S-H2O: C, 55.46; H, 5.55; N, 9.95; Cl, 6.30; found: C, 55.64; H, 5.35; N, 9.91; Cl, 6.24. Example 34 3-r4-((3aR.9bR)-c^-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-m-henzopyranor3.4-c1pyrro1-2- yl .hutvn-pyridor3'.2':4.51thienor3.2-d1pyrimidine-2.4riH.3HVdione hydrochloride The product from Example IE (0.414 g, 1.5 mmol) and methyl 3-amino-thieno[2,3- b]pyridine-2-carboxylate (0.328 g, 1.57 mmol) were treated as described in Example IF to yield 0.26 g (34%) of me title compound.: m.p. 195-200°; 1H NMR (300 MHz, CDCI3) δ 1.68-1.9 (m, 4H), 2.3-2.5 (m, 2H), 2.5-2.85 (m, 4H), 3.2-3.9 (m, 4H), 3.79 (s, 3H), 4.01 (dd, IH), 4.19 (t, 2H), 6.42 (d, IH), 6.52 (d, IH), 7.07 (t, IH), 7.48 (dd, IH), 8.57 (m, IH), 8.77 (dd, IH); MS (DCI/NH3) m/e 497 (M+H)+; Analysis calc'd for C25H27CIN4O4S H2O: C, 56.33; H, 5.48; N, 10.51; Cl, 6.65; found: C, 56.32; H, 5.36; N, 10.42; Cl, 6.54. Example 35 3-r4-((3aR.9bRV .γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-clpyrrol-2- ynhutyll-7-methyl-pyridor3 , .2':4.51thienor3.2-d]pyrimidine-2.4(lH.3H)-dione hydrochloride Example 35A Methyl 3-amino-5-methyl-thieno[2.3-blpyridine-2-carboxylate 2-Chloro-3-cyano-6-methyl pyridine (1.5 g, 9.8 mmol) and methyl thioglycolate (0.88 mL, 9.8 mmol) were dissolved in DMF (7 mL). To the solution was added 1.0 g KOH in 5 mL H2O over 30 min. The reaction was then quenched by the addition of ice water, and die product collected by filtration to yield 1.72 g (79%) of die titie compound: 1H NMR (300 MHz, CDCI3) δ 2.88 (s, 3H), 3.91 (s, 3H), 5.90 (br s, 2H), 7.17 (d, IH), 7.82 (d, IH). Example 35B 3-r4-((3aR.9bRV .γ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-f n-benzopyranor3.4-c1pyrrol-2- yl .hutyll-pyridor3'.2':4.51thienor3.2-dlpyrimidine-2.4dH.3HVdione hydrochloride The product from Example IE (0.414 g, 1.5 mmol) and the product from Example 35A (0.350 g, 1.57 mmol) were treated as described in Example IF to yield 0.27 g (34%) of the titie compound.: m.p. 215-20°; *H NMR (300 MHz, CDCI3) δ 1.68-1.9 (m, 4H), 2.3-2.5 (m, 2H), 2.5-2.8 (m, 4H), 2.71 (s, 3H), 3.2-3.9 (m, 4H), 3.77 (s, 3H), 4.02 (dd, IH), 4.17 (t, 2H), 6.44 (d, IH), 6.53 (d, IH), 7.07 (t, IH), 7.34 (d, IH), 8.41 (d, IH); MS (DCI/NH3) m/e 493 (M+H)+; Analysis calc'd for C26H29CIN4O4S I.5H2O: C, 56.16; H, 5.80; N, 10.08; Cl, 6.38; found: C, 56.00; H, 5.37; N, 10.01; Cl, 5.99. E ample 36 3-r4-f(3aR.9hR)-c .γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-henzopyranor3.4-c1pyrrol-2- ynbutyll-9-methoxy-pyridor3'.2':4.51thienor3.2-d1pyrimidine-2.4flH.3HVdione hydrochloride Example 36A Methyl 3-amino-4-methoxy-thienor2.3-blpyridine-2-carhoxylate To 2-chloro-3-cyano-4-methoxypyridine (2.02 g) and methyl thioglycolate (1.1 mL) in DMF (24 mL) at 5°C was added a 1.0 M solution of KOtBu/THF (14.6 mL). The reaction was stirred 20 min at 5°, then 1 h at RT, quenched in saturated NH4CI, the solid coUected, washed widi water and sucked dry. This was recrystalUzed from EtOAc to give 0.89 g of the titie compound. Example 36B 3-r4-((3aR.9bRV ..-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-benzopyranor3.4-clpyrrol-2- yl)butyll-9-methoxy-pyridor3'.2':4.51thienor3.2-d1pyrimidine-2.4(lH.3H -dione hydrochloride The product from Example IE (0.414 g, 1.5 mmol) and the product from Example 36A (0.350 g, 1.57 mmol) were treated as described in Example IF to yield 0.40 g (44%) of the titie compound: m.p. 180-200°; l NMR (300 MHz, CDCI3) δ 1.61 (2H, br), 1.78 (2H, m), 2.23 (2H, br), 2.60 (3H, br), 3.20 (IH, br), 3.45 (2H, br), 3.75 (IH, m), 3.81 (3H, s), 4.03 (IH, dd), 4.10 (IH, t), 4.14 (3H, s), 6.44 (IH, d), 6.51 (IH, d), 6.82 (IH, d), 7.04 (IH, t), 8.60 (IH, d), 8.90 (IH, br s); MS (DCI/NH3) m/e 509; Analysis calc'd for C26H29C1N4O5S HC1- (H2θ)2- (C4Hgθ2)0.5: C, 53.80; H, 5.97; N, 8.96; Cl, 5.67; found: C, 53.54; H, 5.68; N, 8.92; Cl, 5.73. Example 37 3-r4-ff3aR.9bRV ι -9-Methoxv-1.2.3.3a.4.9h-hexahvdro-m-benzopyranor3.4-c1pyrrol-2- vnbutyll-8-chloro-pyridor2'.3':4.51thienor3.2-dlnyrimidine-2.4flH.3HVdione hvdroch1oridp. The product from Example IE (0.357 g, 1.25 mmol) and the product from Example 6A (0.30 g, 1.24 mmol) were treated as described in Example IF to yield 0.30 g (47%) of die title compound: m.p. 196-198°; *H NMR (300 MHz, CDCl3(free base)) δ 8.15 (d, IH), 7.47 (d, IH), 7.05 (t, IH), 6.48 (d, IH), 6.42 (d, IH), 4.08 (t, 2H), 4.02 (dd, IH), 3.85 (m, IH), 3.78 (s, 3H), 3.5 (m, 2H), 2.78 (m, 4H), 2.5 (m, 2H), 1.76 (m, 4H); MS (DCI/NH3) m/e 513(M+H)+; Analysis calc'd for C25H25C1N4O4S-HC1-2H2O: C, 51.09; H, 5.28; N, 9.25; found: C, 51.20; H, 5.33; N, 9.55. Example 38 3-r4-(GaR.9bRVct..-9-Methoxy-1.2.3.3a.4.9h-hexahydro-rn-henzopyranol3.4-clpyrrol-2- ynbutyll-7-chloro-ρyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione hydrochloride Example 38A Methyl 3-amino-6-chloro-thieno[3.2-blpyridine-2-carboxylate The product from Example 27 A (3.46 g, 20 mmol) and methyl thioglycolate (1.8 mL, 20 mmol) were combined in 40 mL THF. To the solution was added 1.08 g NaOMe (20 mmol) After 1.5 h, and additional 1.08 g NaOMe was added, and then after an additional 2h, the reaction was quenched in 5% aq. NaHCO3 and extracted with diethyl ether. The organic extracts were dried (MgSO4), evaporated, and the product was purified by stiica gel colmun chromatography to yield 1.23 g (25%) of the title compound: *H NMR (300 MHz, CDCI3) δ 3.92 (s, 3H), 6.20 (br s, 2H), 8.04 (d, IH), 8.54 (d, IH). Example 38B 3-r4-((3aR.9bRVc/.γ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-benzopyrano[3.4-clpyrrol-2- yl)butyll-7-chloro-pyridor2'.3':4.51thieno[3.2-d]pyrimidine-2.4(lH.3HVdione hydrochloride The product from Example IE (0.357 g, 1.25 mmol) and me product from Example 38 A (0.30 g, 1.24 mmol) were treated as described in Example IF to yield 0.29 g (46%) of the title compound: m.p. 224-226°; l U NMR (300 MHz, DMSO-d6) δ 8.88 (m, 2H), 7.13 (t, IH), 6.62 (d, IH), 6.5 (d, IH), 4.05 (dd, IH), 3.96 (t, 2H), 3.82 (m, IH), 3.8 (s, 3H), 3.2 (m, 2H), 2.95 (m, IH), 2.85 (m, 3H), 2.3 (m, 2H), 1.7 (m, 4H); Analysis calc'd for C25H25C1N4O4S-HC1-0.75H2O: C, 53.22; H, 5.16; N, 9.39; found: C, 53.24; H, 5.04; N, 9.93. Example 39 3-r4-r(3aR.9bR)-e .γ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ni-henzopyranor3.4-clpyrro1-2- vnhutvn-8-Dhenyl-pyτazinor2'.3':4.51thienor3.2-d1pyrimidine-2.4flH.3HVdione hydrochloride The product from Example IE (0.357 g, 1.25 mmol) and the product from Example 9B (0.356 g, 1.25 mmol) were treated as described in Example IF to yield, after recrystaUization from methanol, 0.35 g (63%) of the title compound: m.p. 291°; *H NMR (300 MHz, CDCl3(free base)) δ 9.08 (s, IH), 8.07 (dd, 2H), 7.58 (m, 3H), 6.88 (t, IH), 6.30 (d, IH), 6.20 (d, IH), 4.18 (m, 2H), 3.88 (dd, IH), 3.72 (s, 3H), 3.63 (m, 2H), 3.38 (m, 2H), 2.72 (m, 3H), 2.6 (m, IH), 2.5 (m, IH), 1.8 (m, 4H); MS (DCI/NH3) m/e 556(M+H+); Analysis calc'd for C30H29N5SO4-HC1: C, 60.85; H, 5.10; N, 11.82; Cl, 5.98. Found C, 60.50; H, 5.20; N, 11.69; Cl, 6.07. Example 40 3-r4-((3aR.9bR)- .γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-henzopyranor3.4-c1pyrrol-2- yl hutyl1-7-phenyl-pyrazinor2'.3':4.51thienor3.2-d1pyrimidine-2.4f lH.3H -dione hydrochloride Example 40A 3-Cyano-2-chloro-6-phenylpyrazine 3-Carboxamido-2-hydroxy-6-phenylpyrazine (7.56 g, 35.13 mmol), prepared by the method of Dick and Wood, J. Chem. Soc, 1379 (1955), was suspended in triethylamine (7.11 g, 70.26 mmol), cooled to 0 °C and dissolved in 50 ml POCI3. The mixture was refluxed for 3 h before concentrating in vacuo . The resulting black oil was extracted 5 x 100 ml Et2θ and the combined extracts treated with 250 ml cold 10 % Na2CO3. The layers were separated and die organic phase washed with water, brine and dried over Na2SO4. Concentration gave the title compound (3.20 g, 42%) as a tan solid, mp: 143-145 °C; l U NMR (300 MHz, CDCI3) δ 7.57 (m, 3H), 8.10 (m, 2H), 9.05 (s, IH); MS (DCI/NH3) m/e 233 (M+NH4)+. Example 40B Ethyl-7-amino-3-phenyl-thienor2.3-hlpyrazine-6-carhoxylate The compound resulting from Example 40A (1.00 g, 4.65 mmol) was treated with ethyl thioglycolate (0.56 g, 4.65 mmol) and Na2CO3 (0.49 g, 4.65 mmol) in 20 ml EtOH. Recrystallization of the crude product from EtOH H2θ gave the title compound (1.19 g, 86%) as a yellow-green solid, mp: 173-175 °C. *H NMR (300 MHz, CDCI3) δ 1.42 (t, 3H), 4.41 (q, 2H), 6.18 (br s, 2H), 7.55 (m, 3H), 8.12 (m, 2H), 9.03 (s, IH). MS (DCI/NH3) m/e 300 (M+H)+. Example 40C 3-r4-((3aR.9hRV.? .γ-9-Methoxy-1.2.3.3a.4.9b-hexahydro-ril-benzopyranor3.4-c1pyrrol-2- yl)butyll-7-phenyl-pyrazino[2'.3':4.51thieno[3.2-d]pyrimidine-2.4(lH.3H)-dione hydrochloride The product from Example IE (0.357 g, 1.25 mmol) and die product from Example 40B (0.356 g, 1.25 mmol) were treated as described in Example IF to yield 0.30 g (59%) of the title compound: l U NMR (300 MHz, CDC_3(free base)) δ 9.13 (s, IH), 8.18 (dd, 2H), 7.79 (m, 3H), 7.04 (t, IH), 6.45 (t, 2H), 4.12 (t, 2H), 4.01 (dd, IH), 3.88 (m, IH), 3.81 (s, 3H), 3.55 (m, 2H), 3.45 (m, IH), 2.78 (m, 3H), 2.62 (m, 2H), 1.78 (m, 4H); MS (DCI/NH3) m/e 556(M+H)+; Analysis calc'd for C30H29N5SO4ΗCH.5H2O: C, 58.20; H, 5.37; N, 11.31; found: C, 58.51; H, 5.31; N, 11.33. Example 41 3-r4-((3aS.9hR tr < mγ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-πi-benzopyranor3.4-c1pyrrol-2- yl.butyll-pyridor3'.4':4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione dihydrochloride The product from Example 3E (210 mg, 0.75 mmol), 3-amino-2- carbomethoxythieno[3,2-c]pyridine (.17 g, .83 mmol) (J. Heterocyclic Chem., 24, 85 (1987)), E.3N (.40 mL, 2.9 mmol), and phosgene (0.43 mL 1.93 M solution in toluene, .83 mmol) were treated as described in Example IF to yield 0.20 g (56%) of the titie compound: m.p. > 250°; IH NMR (300 MHz, CDCI3 (free base)) δ 1.72-1.93 (m, 4H), 2.29-2.43 (m, IH), 2.74 (t, J=10 Hz, IH), 2.83-2.98 (m, 4H), 3.16 (dd, J=8, 10 Hz, IH), 3.73 (s, 3H), 3.75-3.83 (m, IH), 4.03 (dd, J=l, 10 Hz, IH), 4.21 (t, J=7 Hz, 2H), 4.43 (dd, J=4, 10 Hz, IH), 6.36 (dd, J=l, 8 Hz, IH), 6.46 (dd, J=l, 8 Hz, IH), 7.05 (t, J=8 Hz, IH), 7.80 (dd, J=l, 6 Hz, IH), 8.61 (d, J=6 Hz, IH), 9.54 (d, J=l Hz, IH); MS (DCI(NH3)) /e 479 (M+H)+; Analysis calc'd for C25H26N4θ4S » (HCl)2 « H2θ « (CH3θH)o.5: C, 52.31; H, 5.51; N, 9.57; found: C, 51.95; H, 5.22; N, 9.27. Example 42 3-I -. f 3aS.9hRV tmn.γ-9-Methoxy- 1.2.3.3a.4.9b-hexahvdro-r 1 l-henzopyranor3.4-clpyrrol-2- yl)butyll-pyridor4'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione dihydrochloride The product from Example 3E (200 mg, 0.72 mmol), 3-amino-2- carbomethoxythieno[2,3-c]pyridine (.16 g, .79 mmol) (J. Heterocyclic Chem., 24, 85 (1987)), Et3N (.40 mL, 2.9 mmol), and phosgene (0.41 mL 1.93 M solution in toluene, 0.79 mmol) were treated as described in Example IF to yield 0.20 g (58%) of the titie compound: m.p. 221-223°; l U NMR (300 MHz, CDCI3 (free base)) δ 1.76-1.96 (m, 4H), 2.37-2.50 (m, IH), 2.72-2.82 (m, IH), 2.89-3.11 (m, 4H), 3.18-3.28 (m, IH), 3.73 (s, 3H), 3.80-3.89 (m, IH), 4.04 (dd, J=l, 9 Hz, IH), 4.22 (t, J=7 Hz, 2H), 4.45 (dd, J=4, 10 Hz, IH), 6.38 (d, J=8 Hz, IH), 6.54 (d, J=8 Hz, IH), 7.08 (t, J=8 Hz, IH), 8.10 (d, J=6 Hz, IH), 8.64 (d, J=6 Hz, IH), 9.19 (s, IH); MS (DCI(NH3)) m/e 479 (M+H)+; Analysis calc'd for C25H26N4O4S « (HC1)2 « (H2O)0.75: C, 53.15; H, 5.26; N, 9.92; found: C, 53.18; H, 5.18; N, 9.70. Example 43 3-r4-( , πaS.9bRV<rα».γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-henzopyranor3.4-c1pyrrol-2- vDhutyl1-8-methoxy-pyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H -dione hydrochloride The product from Example 3E (0.276 g, 1.00 mmol) and the product from Example 31A (0.25 g, 1.05 mmol) were treated as described in Example IF to yield 0.10 g (50%) of the title compound: l U NMR (300 MHz, CDC_3(free base)) δ 8.02 (d, IH), 7.04 (t, IH), 6.92 (d, IH), 6.48 (d, IH), 6.39 (d, IH), 5.39 (m, IH), 4.45 (dd, IH), 4.11 (t, 2H), 4.04 (m, IH), 3.76 (s, 3H), 3.59 (q, IH), 2.96 (q, IH), 2.76 (m, 4H), 2.58 (m, IH), 2.3 (m, IH), 1.77 (m, 4H), 1.42 (d, 6H); MS (DCI/NH3) m/e 537(M+H)+; Analysis calc'd for C28H32N4O5S-HC.- l.5H2O: C, 56.04; H, 6.05; N, 9.34; found: C, 56.04; H, 5.70; N, 9.14. Example 44 3-r4-rr3aS.9bRVtrαn.γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-henzopyranor3.4-c1pyrrol-2- yl ) hutvn-pyridor3'.2':4.51thienor3.2-d1pyrimidine-2.4flH.3H -dione hydrochloride The product from Example 3E (0.276 g, 1.0 mmol) and methyl 3-amino-thieno[2,3- b]pyridine-2-carboxylate (0.229 g, 1.1 mmol), as described in Example 35A, were treated as described in Example IF to yield 0.185 g (36%) of the title compound: m.p. 217-8°; 1H NMR (300 MHz, DMSO-d6) δ 1.6-1.8 (m, 4H), 2.1-2.7 (m, 2H), 2.8-3.5 (m, 5H), 3.78 (s, 3H), 3.97 (m, 2H), 4.10 (q, IH), 4.47 (m, IH), 6.46 (d, IH), 4.56 (d, IH), 7.13 (t, IH), 7.65 (dd, IH), 8.75 (dt, IH), 8.84 (dd, IH), 10.55 (br s, IH), 12.74 (d, IH); MS (DCI/NH3) m/e 479(M+H)+; Analysis calc'd for C25H27C1N4O4S-1.5H2O: C, 55.39; H, 5.57; N, 10.33; found: C, 55.43; H, 5.17; N, 10.32. Example 45 3-| " 4-((3aS.9bR)-trα/;.y-9-Methoxy-1.2.3.3a.4.9b-hexahydro-[11-benzopyrano[3.4-clpyrrol-2- yl.butyll-7-methyl-pyridor3'.2':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione hydrochloride The product from Example 3E (0.276 g, 1.0 mmol) and the product from Example 35 A (0.244 g, 1.1 mmol) were treated as described in Example IF to yield 0.090 g (17%) of the titie compound: m.p. 243-5°; l U NMR (300 MHz, DMSO-d6) δ 1.6-1.8 (m, 4H), 2.1-2.7 (m, 3H), 2.66 (s, 3H), 2.8-3.8 (m, 6H), 3.77 (s, 3H), 3.96 (m, 2H), 4.12 (m, IH), 4.45 (m, IH), 6.46 (d, IH), 6.56 (d, IH), 7.12 (t, IH), 7.51 (d, IH), 8.60 (d, IH); MS (DCI/NH3) m/e 493 (M+H)+; Analysis calc'd for C26H29C1N4O4S-H2O: C, 57.08; H, 5.71; N, 10.24; found: C, 56.93; H, 5.22; N, 9.94. Example 46 3- 4-((3aS.9bR)-trfl -9-Methoxy-1.2.3.3a.4.9b-hexahydro-[ll-benzopyrano 3.4-clpyrrol-2- yl)butyll-7-methoxy-pyridor3'.2':4.51thienor3.2-dlpyrimidine-2.4(lH.3H dione hydrochloride The product from Example 3E (0.248 g, 0.90 mmol) and the product from Example 33A (0.238 g, 1.0 mmol) were treated as described in Example IF to yield 0.301 g (61%) of the title compound: m.p. 260-3°; *H NMR (300 MHz, DMSO-d6) δ 1.6-1.8 (m, 4H), 2.1-2.7 (m, 3H), 2.8-3.6 (m, 6H), 3.74 (s, 3H), 3.95 (m, 2H), 3.97 (s, 3H), 4.07 (t, IH), 4.28 (m, IH), 6.46 (d, IH), 6.55 (d, IH), 7.07 (d, IH), 7.11 (t, IH), 8.59 (d, IH); MS (DCI NH3) m/e 509 (M+H)+; Analysis calc'd for C26H29C1N4O5S-3/4H2O: C, 55.91; H, 5.50; N, 10.03; Cl, 6.35; found: C, 55.75; H, 5.32; N, 10.00; Cl, 6.44. Example 47 3-r4-((3aS.9bR -trαAiγ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4-c1pyrro1-2- yl)butyll-7-chloro-pyrido 3'.2':4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione hydrochloride The product from Example 3E (0.248 g, 0.90 mmol) and the product from Example 32 A (0.242 g, 1.0 mmol) were treated as described in Example IF to yield 0.285 g (58%) of the title compound: m.p. 245-50°; NMR (300 MHz, DMSO-d6) δ 1.6-1.8 (m, 4H), 2.1- 2.7 (m, 2H), 2.8-3.6 (m, 5H), 3.77 (s, 3H), 3.8-4.2 (m, 2H), 3.95 (m, 2H), 4.10 (t, IH), 4.47 (m, IH), 6.46 (d, IH), 6.54 (d, IH), 7.11 (t, IH), 7.78 (d, IH), 8.75 (d, IH); MS (DCI NH3) m/e 513 (515 (M+H)+); Analysis calc'd for C25H26CI2N4O4S-O.5H2O-O.IHCI: C, 53.42; H, 4.86; N, 9.97; Cl, 13.24; found: C, 53.25; H, 7.73; N, 9.68; Cl, 13.31. Example 48 3- r 4-((3aR.9hRV c/.v-9-Methoxy- 1.2.3.3a.4.9b-hexahvdro-r n-henzopyranor3.4-c1pyrrol-2- ynbutyll-9-chloro-pyridor3'.4':4.51thieno[3.2-d1pyrimidine-2.4πH.3HVdione hydrochloride Example 48A Methyl 3-amino-4-chloro-thienor3.2-c]pyridine-2-carboxylate To 3-cyano-2,4-dichloropyridine (653 mg) and mediyl thioglycolate (340 μL) in DMF (12 mL) at 5°C was added a solution of 1.0 M KOtBu/THF (4.5 mL). The reaction was stirred 20 min at 5° then 1 h at RT, then quenched in sat'd NH4CI, the solid precipitate coUected, washed with water and sucked dry to give 800 mg (88%) of the title compound. Example 48B 3-r4-((3aR.9bR.- ..-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ni-benzopyranor3.4-c1pyrrol-2- yl)butyll-9-chloro-pyridor3'.4':4.51thieno[3.2-dlpyrimidine-2.4(lH.3H)-dione hydrochloride The product from Example IE (0.276 g, 1.0 mmol) and the product from Example 48A (0.242 g, 1.0 mmol) were treated as described in Example IF to yield 0.280 g (55%) of die titie compound: l U NMR (300 MHz, CDCI3) δ 1.75 (4H, br m), 2.40 (2H, br), 2.65 (3H, br), 3.30 (IH, br), 3.50 (2H, br), 3.80 (3H, s), 3.86 (IH, br), 4.02 (IH, dd), 4.10 (IH, t), 6.45 (IH, d), 6.52 (IH, d), 7.08 (IH, t), 7.79 (IH, d), 8.40 (IH, d); MS (CI(NH3)) m/e 513 (M+H)+; Analysis calc'd for C25H25C1N4O4S-HC1: C, 52.49; H, 4.89; N, 9.79; found: C, 52.28; H, 4.55; N, 9.44. Example 49 3-r4-. r3aS.9bR)-trαn.γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-πi-henzonyranor3.4-clpyrro1-7.- yl.butyll-9-methoxy-pyridor3'.4':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione fumarate Example 49A Methyl 3-amino-4-methoxy-thienor3.2-c]pyridine-2-carboxylate The product from Example 48A (1.2 g, 4.9 mmol) and sodium medioxide (1.0 g, 19 mmol) were refluxed in 30 mL MeOH for 6 h. The reaction was partitioned between water and CH2CI2. The layers were seperated and the aqueous layer was extracted with CH2CI2. The combined organic layers were dried (MgSO4), filtered, and concentrated. SUica gel chromatography (CH2CI2) yielded 1.1 g (78 %) of the title compound: 1H NMR (300 MHz, DMSO-d6) δ 3.79 (s, 3H), 4.05 (s, 3H), 6.96 (bs, 2H), 7.47 (d, J=6 Hz, IH), 8.07 (d, J=6 Hz, IH); MS (DC NH3)) m/e 239 (M+H)+. Example 49B 3-[4-((3aS.9bR -trαn.v-9-Methoxy- 1.2.3.3a.4.9b-hexahydro- ll-henzopyranor3.4-clpyrrol-2- vnbutyll-9-methoxy-pyridor3'.4':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione fumarate The product from Example IE (0.140 g, 0.50 mmol), the product from Example 49A (0.145 g, 0.61 mmol), Et3N (0.18 mL, 1.3 mmol), and phosgene (1.1 mL 1.93 M solution in toluene, 2.1 mmol) were treated as described in Example IF substituting fumaric acid for the salt forming step to yield 0.22 g (87%) of the title compound: m.p. 232-233°; l U NMR (300 MHz, CDCI3 (free base)) δ 1.60-1.84 (m, 4H), 2.24-2.40 (m, IH), 2.55-2.65 (m, IH), 2.72- 2.90 (m, 4H), 2.95-3.03 (m, IH), 3.60-3.69 (m, IH), 3.76 (s, 3H), 4.05 (dd, J=10, 11 Hz, IH), 4.11 (t, J=7 Hz, 2H), 4.20 (s, 3H), 4.46 (dd, J=4, 9 Hz, IH), 6.39 (d, J=8 Hz, IH), 6.48 (d, J=8 Hz, IH), 7.05 (t, J=8 Hz, IH), 7.39 (d, J=6 Hz, IH), 8.16 (d, J=6 Hz, IH); MS (DCI(NH3)) m/e 509 (M+H)+; Analysis calc'd for C26H28 4θ5S « C4H4θ4*(H2θ)o.25: C, 57.27; H, 5.21; N, 8.90; found: C, 56.96; H, 4.95; N, 8.83. Example 50 3-r4-(r3aS.9hRVtr^γ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4-c1pyrrol-2- yl)butyll-8-phenyl-pyrazinor2'.3 l :4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione hydrochloride The product from Example 3E (0.276 g, 1.0 mmol) and the product from Example 9B (0.308 g, 1.08 mmol) were treated as described in Example IF to yield 0.41 g (73%) of the titie compound: m.p. >250°; l U NMR (300 MHz, CDCl3(free base)) δ 9.03 (s, IH), 8.02 (m, 2H), 7.58 (m, 3H), 7.0 (t, IH), 6.4 (d, IH), 6.31 (d, IH), 3.98 (m, 2H), 4.05 (dd, IH), 3.85 (t, 2H), 3.62 (m, IH), 3.06 (m, 3H), 2.85 (m, 2H), 2.22 (m, IH), 1.82 (m, 4H); MS (DCI/NH3) m/e 556(M+H)+; Analysis calc'd for C30H29N5O4S-HC1-2H2O: C, 57.36; H, 5.46; N, 11.15; found: C, 57.31; H, 5.23; N, 10.99. Example 51 3-r4-((3aS.9hRV<rflΛϊ.γ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-rn-benzopvranor3.4-clpvrrol-2- yl)butyll-8-isopropoxy-pyridof2'.3':4.51thieno[3.2-d]pyrimidine-2.4flH.3H)-dione hydrochloride Example 51 A Isopropyl 3-amino-5-isopropoxy-thieno[3.2-blpyridine-2-carboxylate Na metal (0.47 g, 20 mmol) was added to 2-propanol (150 mL) and the reaction was heated to reflux until all the sodium was consumed. To the resulting solution was added methyl 3-Amino-7-chloro-thieno[3,2-b]pyridine-2-carboxylate (prepared as described in Example 5A), (0.50 g, 2.06 mmol) and the solution was heated to reflux for 48 h. Solvent was evaporated and the product was partitioned between aq. NH4CI and CH2CI2. The organic phase was dried, concentrated, and the product purified by silica gel chromatography to yield 0.11 g (19%) of the title compound: l U NMR (300 MHz, CDCI3) 7.85 ( d,lH), 6.91 (d,lH), 5.98 (bs,lH), 5.42 (m, IH), 5.25 (m, IH), 1.42 (d, 6H), 1.38 (d,6H); MS (DCI/NH3) m/e 295(M+H)+: Example 5 IB 3-r4-rGaS.9bR)-trfl».v-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4-clnyrrol-2- yDhutyll-8-isopropoxy-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione hydrochloride The product from Example 3E (0.102 g, 0.37 mmol) and die product from Example 51 A (0.11 g, 0.37 mmol) were treated as described in Example IF to yield 0.10 g (50%) of the title compound: H NMR (300 MHz, CDCl3(free base)) δ 8.02 (d, IH), 7.04 (t, IH), 6.92 (d, IH), 6.48 (d, IH), 6.39 (d, IH), 5.39 (m, IH), 4.45 (dd, IH), 4.11 (t, 2H), 4.04 (m, IH), 3.76 (s, 3H), 3.59 (q, IH), 2.96 (q, IH), 2.76 (m, 4H), 2.58 (m, IH), 2.3 (m, IH), 1.77 (m, 4H), 1.42 (d, 6H); MS (DCI/NH3) m/e 537(M+H)+; Analysis calc'd for C28H32N4O5S.HCM.5H2O: C, 56.04; H, 6.05; N, 9.34; found: C, 56.04; H, 5.70; N, 9.14. Example 52 3-r4-((3aS.9hR)-trαm-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-rn-henzopyranor3.4-clpyrrol-2- yl.hutyll-8-phenyl-pyridor2'.3':4.51thienor3.2-d1pyrimidine-2.4nH.3HVdione dihydrochloride Example 52A Methyl 3-amino-5-phenyl-thienor3.2-blpyridine-2-carboxylate Methyl 3-amino-5-chloro-thieno[3,2-b]pyridine-2-carboxylate, prepared as described in Example 6A (0.243 g, 1.0 mmol), phenylboronic acid (0.134 g, 1.1 mmol) and triethylamine (0.20 mL) were added to 3 mL of DMF containing [1,1'- bis(diphenylphosphino)ferrocene]palladium(II) chloride (1:1 complex with CH2CI2) under N2. The mixture was stirred at 90°C for 4 h. The reaction was then cooled and dUuted with E_2θ. The organic layer was washed with H2O, brine, dried (MgSO4), concentrated and chromatographed (2:1 CH2θ2:hexane) to yield the title compound (140 mg, 50 %): ^H NMR (300 MHz, CDCI3) δ 3.93 (s, 3H), 6.30 (bs, 2H), 7.41-7.55 (m, 3H), 7.84 (d, J=8 Hz, IH), 8.07-8.13 (m, 3H); MS (DCI(NH3)) m/e 285 (M+H)+. Example 52B 3-r4-((3aS.9bRVtr^γ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4-clpyrro1-2- vnhutyll-8-phenyl-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4πH.3H.-dione dihydrochloride The product from Example 3E (0.21 g, 0.75 mmol), the product from Example 52A (235 mg, 0.83 mmol), Et3N (0.26 mL, 1.9 mmol), and phosgene (0.5 mL 1.93 M solution in toluene, 0.95 mmol) were treated as described in Example IF to yield 0.300 g (72%) of the titie compound: m.p. > 250°; *H NMR (300 MHz, CDCI3 (free base)) δ 1.59-1.71 (m, 2H), 1.74- 1.87 (m, 2H), 2.19-2.34 (m, IH), 2.59 (dd, J=9, 11 Hz, IH), 2.72-2.84 (m, 4H), 3.00 (dd, J=7, 9 Hz, IH), 3.55-3.67 (m, IH), 3.73 (s, 3H), 4.00 (dd, J=10, 12 Hz, IH), 4.18 (t, J=7 Hz, 2H), 4.38 (dd, J=4, 10 Hz, IH), 6.38 (dd, J=l, 8 Hz, IH), 6.46 (dd, J=l, 8 Hz, IH), 7.08 (t, J=8 Hz, IH), 7.44-7.56 (m, 3H), 7.92 (d, J=8 Hz, IH), 8.04-8.11 (m, 2H), 8.26 (d, J=8 Hz, IH); MS (DCI(NH3)) m/e 555 (M+H)+; Analysis calc'd for C3iH3()N4θ4S'(HCl)2'(H2θ)o.5_ C, 58.49; H, 5.23; N, 8.80; found: C, 58.18; H, 5.23; N, 8.47. Example 53 3-r4-((3aR.9bRVr .y-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-rn-benzopyranor3.4-clpyrrol-2- vDbutyll-6-chloro-pyridor4'.3':4.51thienor3.2-d1pyrimidine-2.4(lH.3HVdione Example 53 A Methyl-3-amino-7-chloro-thienof2.3-clpyridine-2-carboxylate 3-Chloro-4-cyanopyridine, prepared as described in J. Heterocyclic Chem., 15, 683 (1978), (2.9 g, 21 mmol) was dissolved in acetic acid (15 mL) and 30%H2θ2 (15 mL) was added over 5 min. The reaction was stirred at 80° for 18 h. After cooling to room temp., the white solid product (2.5 g) was collected by filtration and dried. The N-oxide was then disolved in DMF (50 mL) and methyl thioglycolate (1.45 mL, 16 mmol) was added. Sodium methoxide (0.86 g, 16 mmol) was then added. The reaction was stirred for lh, poured into ice/water, and the product collected by filtration, and dried. The resulting solid was suspended in POCI3 (40 mL) and heated at reflux for lh. The reaction was quenched on ice, extracted with ether, and the organic extracts washed several times with aq. 5% NaHCO3. Silica gel column chromatography (85:15 hexane:ethyl acetate) yielded 0.42 g of the minor isomer (methyl-3-amino-5-chloro-thieno[2,3-c]pyridine-2-carboxylate) and 1.05 g of the titie compound. Example 53B 3-r4-(f3aR.9bR.-e/.γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-c1pyrro1-2- yl.hutyll-6-chloro-pyridor4'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H.-dione The product from Example IE (0.42 g, 1.5 mmol), me product from Example 53 A (0.364 g, 1.5 mmol), E.3N (0.5 mL, 3.0 mmol), and phosgene (1.6 mL 1.93 M solution in toluene, 3.0 mmol) were treated as described in Example IF to yield 0.26 g (33%) of the title compound: m.p. 191°; l U NMR (300 MHz, CDCI3) δ 1.7-1.8 (m, 2H), 1.8-1.9 (m, 2H), 2.32-2.55 (m, 2H), 2.60-2.80 (m, 3H), 3.27 (m, IH), 3.40-3.90 (m, 4H), 3.78 (s, 3H), 4.01 (dd, IH), 4.19 (t, 2H), 6.43 (d, IH), 6.48 (d, IH), 7.06 (t, IH), 8.04 (d, IH), 8.46 (d, IH); MS (DCI/NH3) m/e 513, 515 (M+H)+; Analysis calc'd for C25H25C1N4O4S-H2O: C, 56.55; H, 5.12; N, 10.55; found: C, 56.32; H, 5.03; N, 10.44. Example 54 3-r4-((3aS.9bR)-tr_ y-9-Methoxy- 1.2.3.3a.4.9b-hexahydro-ri]-benzopyranof3.4-c1pyrrol-2- vnhutvn-6-chloro-pyridor4'.3':4.51thienor3.2-d1pyrimidine-2.4(lH.3H -dione The product from Example 3E (0.42 g, 1.5 mmol), the product from Example 53 A (0.364 g, 1.5 mmol), Et3N (0.5 mL, 3.0 mmol), and phosgene (1.6 mL 1.93 M solution in toluene, 3.0 mmol) were treated as described in Example IF to yield 0.31 g (40%) of the title compound: m.p. 230°; l U NMR (300 MHz, CDC13) δ 1.50-1.75 (m, 4H), 2.18 (m, IH), 2.66 (t, IH), 2.82 (m, 4H), 3.07 (t, IH), 3.1-3.9 (m, 5H), 3.71 (s, 3H), 3.95 (m, 2H), 4.05 (dd, IH), 4.42 (dd, IH), 6.40 (d, IH), 6.47 (d, IH), 7.04 (t, IH), 8.21 (d, IH), 8.50 (d, IH); MS (DCI/NH3) m/e 513, 515 (M+H)+; Analysis calc'd for C25H25C1N4O4S-0.5H2O: C, 57.52; H, 5.02; N, 10.73; found: C, 57.33; H, 4.72; N, 10.73. Example 55 3-r4-((3aS.9bR -tr^.-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-πi-henzopyranof3.4-clpyrrol-2- vnbutyll-8-methoxy-pyridor3'.2':4.51thienor3.2-d]pyrimidine-2.4πH.3H -dione hydrochloride Example 55A Methyl 2-amino-5-methoxy-thieno[2.3-hlpyridine-2-carboxylate To 2-chloro-3-cyano-5-methoxypyridine (0.53 g) and methyl thioglycolate (280 μL) in DMF (10 mL) at 5°C was added a 1.0 M solution of KOtBu/THF (3.8 mL). The reaction was stirred 20 min at 5°, dien 2 h at RT, quenched in sat'd NH4CI, the solid precipitate was collected, washed with water and dried to give 0.53 g (71%) of the title compound. Example 55B 3-r4- (( 3aS.9bRVtr^iv-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-henzopyranor3.4-clnyrrol-2- yl_butyll-8-methoxy-pyridor3'.2':4.51thienor3.2-dlpyrimidine-2.4riH.3H -dione hydrochloride The product from Example 3E (0.223 g, 0.80 mmol) and the product from Example 55A (0.192 g, 0.80 mmol) were treated as described in Example IF to yield 0.315 g (77%) of the title compound: m.p. 207-213°; l U NMR (300 MHz, DMSO-d6) δ 1.5 (2H, m), 1.65 (2H, m), 2.12 (IH, m), 2.57 (IH), 2.7 (4H, m), 2.9 (IH, t), 3.48 (IH, m), 3.7 (3H, s), 3.92 (3H, s), 3.94 (2H), 4.02 (IH, dd), 4.4 (IH, dd), 6.4 (IH, d), 6.45 (IH, d), 7.02 (IH, t), 8.32 (IH, d), 8.56 (IH, d); MS (CI(NH3)) /e 509; Analysis calc'd for C26H29CIN4O5: C, 54.59; H, 5.64; N, 9.79; found: C, 54.61; H, 5.60; N, 9.72. Example 56 3-r4-((3aR.9hRVc^-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-πi-henzopyranor3.4-clpyrrol-2- vnbutyll-8-(3-pyridyl)-pyridor2'.3 l :4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione dihydrochloride Example 56A Methyl 3-amino-5-(3-pyridv thienyr3.2-b1pyridine-2-carboxylate A solution of the methyl 3-amino-5-chloro-thieno[3,2-b]pyridine-2-carboxylate prepared as described in Example 5 A (0.252 g), diethyl 3-pyridyl-borane (0.155 g), Pd(dppf)Cl2 (0.082 g) and K2CO3 (420 mg) in degassed DMF (5 mL) was heated to 95°C for 1.5 h, cooled, quenched in sat'd NH4CI, the soUd precipitate collected and chromatographed 9:1 hexane/EtOAc to give 0.24 g (81%) of the title compound: 1H NMR (300 MHz, CDC13) δ 3.95 (3H, s), 6.30 (2H, br s), 7.45 (IH, dd), 7.86 (IH, d), 8.19 (IH, d), 8.42 (IH, dt), 8.70 (IH, dd), 9.32 (IH, br d). Example 56B 3-r4-((3aR.9bRV .γ-9-Methoxy- 1.2.3 ■3a.4.9b-hexahvdro-πi-henzopyranor3.4-clpyrrol-2- vnbutvn-8-π-pyridylVpyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione. dihydrochloride The product from Example IE (0.127 g, 0.46 mmol) and the product from Example 56A (0.14 g, 0.49 mmol) were treated as described in Example IF to yield 0.09 g (33%) of die title compound: m.p. 210-211°; 1H NMR (300 MHz, CDC13) δ 9.3 (d, IH), 8.73 (dd, IH), 8.41 (dt, IH), 8.37 (d, IH), 7.99 (d, IH), 7.48 (dd, IH), 7.12 (t, IH), 6.53 (d, IH), 6.48 (d, IH), 4.12 (t, 2H), 4.0 (dd, IH), 3.81 (s, 3H), 3.78 (m, IH), 3.42 (m, 2H), 3.1 (m, IH), 2.6 (m, 3H), 2.2 (m, 2H), 1.85 (m, 2H), 1.68 (m, 2H); MS (DCI/NH3) m/e 556(M+H)+; Analysis calc'd for C30H29N5SO4-2HC1: C, 57.33; H, 4.97; N, 11.14; found: C, 57.04; H, 5.09; N, 10.89. Example 57 3-r4-((3aR.9bRV ..-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-clpyrrol-2- ynbutvn-8-(3-thienylVpyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H.-dione dihydrochloride Example 57 A Memyl 7-amino-2-(3-thieny thienor2.3-b1pyrazine-6-carhoxylate A solution of the methyl 7-amino-2-chloro-thieno[2,3-b]pyrazine-6-carboxylate prepared as described in Example IOC (0.190 g), thiophene-3-boronic acid (0.100 g), Pd(dppf)C12 (0.032 g) and triethylamine (0.22 mL) in degassed DMF was heated to 95°C for 4 h, cooled, quenched in water and extracted with 1:1 Et2θ/EtOAc (3x). The organics were washed 3x with water, brine, dried (Na2SO4), filtered and solvent evaporated to give 0.200 g (88%) of the title compound: l U NMR (300 MHz, CDC13) δ 3.95 (3H, s), 6.23 (2H, br s), 7.50 (IH, dd), 7.79 (IH, dd), 8.05 (IH, dd), 9.00 (IH, s). Example 57B 3-r4- ( f3aR.9hRV .γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-henzopyranor3.4-clpyrrol-2- vDhutyll-8-( ' 3-thienvn-pyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione dihydrochloride The product from Example IE (0.127 g, 0.46 mmol) and the product from Example 57 A (0.13 g, 0.45 mmol) were treated as described in Example IF to yield 0.09 g (36%) of the title compound: λ NMR (300 MHz, CDC13(free base)) δ 9.06 (s, IH), 8.1 (dd, IH), 7.78 (dd, IH), 7.53 (dd, IH), 7.05 (t, IH), 6.45 (dd, 2H), 4.13 (t, 2H), 4.01 (dd, IH), 3.83 (m, IH), 3.8 (s, 3H), 3.52 (m, 2H), 3.3 (m, IH), 2.72 (m, 3H), 2.45 (m, 2H), 1.85 (m, 2H), 1.68 (m, 2H); MS (DCI/NH3) m/e 562(M+H)+; Analysis calc'd for C28H27N5O4S2-HC1-2H2O: C, 53.00; H, 5.09; N, 11.04; found: C, 52.78; H, 4.84; N, 10.72. Example 58 3-r4-((3aS.9hRVtrαn.γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-πi-henzopvranor3.4-c1pvrrol-2- yl)hutyll-8-G-pyridylVpyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4flH.3HVdione trihydrochloride The product from Example 3E (0.127 g, 0.46 mmol) and die product from Example 56A (0.14 g, 0.49 mmol) were treated as described in Example IF to yield 0.095 g (35%) of the title compound: m.p. 238-241°; *H NMR (300 MHz, CDC13(free base)) 6 9.34 (d, IH), 8.76 (d, IH), 8.47 (d, IH), 8.38 (d, IH), 7.99 (d, IH), 7.52 (dd, IH), 7.11 (t, IH), 6.5 (d, IH), 6.41 (d, IH), 4.66 (dd, IH), 4.51 (m, 2H), 4.2 (m, IH), 3.85 (m, IH), 3.78 (s, 3H), 2.83 (m, IH), 2.64 (m, 4H), 2.52 (m, IH), 2.3 (m, IH), 1.78 (m, 2H), 1.72 (m, 2H); MS (DCI/NH3) m/e 456(M+H)+; Analysis calc'd for C30H29N5SO4-3HC1-2H2O: C, 51.40; H, 5.18; N, 9.99; found: C, 51.24; H, 5.23; N, 9.82. Example 59 3-r4-((3aS.9hRVtrαn.y-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-clpyrrol-2- vnhutvn-8-(3-thienylVpyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione dihydrochloride The product from Example 3E (0.13 g, 0.44 mmol) and the product from Example 57A (0.13 g, 0.45 mmol) were treated as described in Example IF to yield 0.045 g (17%) of the title compound: l U NMR (300 MHz, CDC13(free base)) δ 9.09 (s, IH), 8.12 (d, IH), 7 (81, J=d Hz, IH), 7.52 (dd, IH), 7.11 (t, IH), 6.51 (d, IH), 6.42 (d, IH), 4.52 (dd, IH), 4.17 (m, 2H), 4.08 (m, IH), 3.85 (m, IH), 3.8 (s, 3H), 3.2 (m, 4H), 3.1 (m, IH), 2.8 (m, IH), 2.62 (m, IH), 2.05 (m, 2H), 1.95 (m, 2H); MS (DCI/NH3) m/e 562(M+H)+. Example 60 3-r4-((3aS.9bR)-trαn.γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-πi-henzopyranor3.4-clpyrrol-2- ynhutyll-8-(3-pyridyl)-pyrazinor2'.3':4.51thienor3.2-d1pyrimidine-2.4πH.3HVdione, dihydrochloride Example 60A Methyl 7-amino-2-(3-pyridyl)thieno 2.3-blpyrazine-6-carboxylate A solution of the methyl 7-amino-2-chloro-thieno[2,3-b]pyrazine-6-carboxylate prepared as described in Example IOC (0.468 g), diethyl(3-pyridyl)borane (0.293 g), Pd(dppf)Cl2 (0.157 g), and K2CO3 (0.800 g) in degassed DMF (10 mL) was heated to 95°C for 1.5 h, cooled, quenched in sat'd NH4CI, the solid precipitate coUected, washed with water and dried. Purification by sUica gel column chromatographed provided 0.44 g (80%) of die titie compound. l U NMR (DMSO-d6) δ 3.87 (3H, s), 7.25 (2H, br s), 7.6 (IH, dd), 8.75 (2H, m), 9.49 (IH, s), 9.58 (IH, m). Example 60B 3-r4-((3aS.9bRVtrαn.y-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-clpyrrol-2- yl.butyn-8-(3-pyridylVpyrazinof2'.3':4.51thienor3.2-dlpyrimidine-2.4πH.3H)-dione dihydrochloride The product from Example 3E (0.24 g, 0.87 mmol) and the product from Example 60A (0.25 g, 0.87 mmol) were treated as described in Example IF to yield 0.14 g (29%) of the title compound: m.p. 235-240°; l U NMR (300 MHz, CDC13) δ 1.9 (4H, br m), 2.4 (4H, br m), 3.05 (IH, br m), 3.10 (3H, br m), 3.65 (IH, m), 3.74 (3H, s), 4.03 (IH, t), 4.19 (2H, t), 4.40 (IH, dd), 6.38 (IH, d), 6.46 (IH, d), 7.07 (IH, t), 7.45 (IH, dd), 8.40 (IH, dt), 8.80 (IH, dd), 9.05 (IH, s), 9.36 (IH, d); MS (CI(NH3)) m/e 557; Analysis calc'd for C29H28N6O6S-1.75 HC1-2.75 H2O: C, 51.99; H, 5.30; N, 12.54; Cl, 9.26; found: C, 51.78; H, 5.12; N, 12.20; Cl, 9.14. Exam le 61 3-r4-ff3aR.9bR ) -cι.v-9-Methoxy-1.2.3.3a.4.9h-hexahydro-ri1-henzopyranor3.4-c1pyrrol-2- vnhutyll-8-(3-pyridvn-pyrazinor2'.3 l :4.51thienor3.2-d1pyrimidine-2.4πH.3HVdione dihydrochloride The product from Example IE (0.18 g, 0.65 mmol) and the product from Example 60A (0.165 g, 0.58 mmol) were treated as described in Example IF to yield 0.18 g (56%) of the title compound: m.p. 190-205°; 1H NMR (300 MHz, CDC13) δ 1.84 (4H, br m), 2.7-3.05 (6H, br m), 3.5 (4H, br m), 3.72 (3H, s), 3.87 (IH, br d), 4.10 (2H, br m), 4.22 (IH, br m), 6.20 (IH, br s), 6.34 (IH, br d), 6.93 (IH, br t), 7.55 (IH, dd), 8.41 (IH, dt), 8.80 (IH, dd), 9.12 (IH, s), 9.34 (IH, d); MS (CI(NH3)) m/e 557; Analysis calc'd for C29H28N6O4S-1.7 HC1-2.5H2O: C, 52.48; H, 5.27; N, 12.66; Cl, 9.08; found: C, 52.21; H, 5.11; N, 12.42; Cl, 8.80. Example 62 3-r4-(r3aR.9bRVcis-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4-clpyrrol-2- vDhutyll-8-f3-furylVpyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione dihydrochloride Example 62A Methyl 7-amino-2-(3-furyl thienor2.3-b1pyrazine-6-carboxylate A solution of the methyl 7-amino-2-chloro-thieno[2,3-b]pyrazine-6-carboxylate prepared as described in Example IOC (0.300 g, 1.23 mmol), β-furanboronic acid (0.207 g, 1.85 mmol)were dissolved in 12 mL of anhydrous DMF. To this solution was added triethylamine (0.26mL, 1.85 mMol, 1.5 equiv.), DPPP (153 mg, 0.37mMol, 0.3 equiv.) and Pd(OAc)2 ( 83 mg, 0.37mMol, 0.3 equiv.), followed by heating to 90°C for 2h. The solvent was evaporated and the resulting residue was chromatograghed (SiO2, 3: 1 Hexanes / Ethyl Acetate) yielding the product as a tight yellow solid (93 mg): 1H NMR (300 MHz, CDC13) δ 7.02 (m, IH), 7.57 (t, J = 3.0 Hz, IH), 8.15 (m, IH), 8.83 (s, IH). Example 62B 3-r4-((3aR.9bR)-cis-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-πi-benzopyranor3.4-cIpyrrol-2- yl.butyll-8- ( 3-furylVpyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4nH.3H.-dione dihydrochloride The product from Example IE (0.097 g, 0.35 mmol), the product from Example 62A (0.073 g, 0.27 mmol), E.3N (0.1 mL, 0.68 mmol), and phosgene (0.7 mL 1.93 M solution in toluene, 1.4 mmol) were treated as described in Example IF to yield 0.040 g (26%) of the title compound: m.p. 183-186°; *H NMR (300 MHz, DMSO-d6) δ 1.61-1.80 (m, 5H), 2.70-2.81 (m, IH), 1.81-2.96 (m, 2H), 3.12-3.33 (m, 2H), 3.37-3.53 (m, IH), 3.77-3.93 (m, 1H), 3.80 (s, 3H), 3.93-4.02 (m, 2H), 4.02-4.15 (m, 2H), 6.51 (d, J=8 Hz, IH), 6.61 (d, J=8 Hz, IH), 7.14 (t, J=8 Hz, IH), 7.29 (d, J=2 Hz, IH), 7.92 (d, J=2 Hz, 1H), 8.66 (s, IH), 9.28 (s, IH), 10.35 and 10.55 (bs and bs, IH), 12.75 (bs, IH); MS (CI(NH3)) m/e (M+H)+ at 546; Analysis calc'd for C28H27N5θ5S»(HCl)2_ C, 54.37; H, 4.73; N, 11.32; found: C, 54.48; H, 5.03; N, 11.13. Example 63 3-r2-((+Ve/..-7-Methoxy-1.2.3.3a.4.9b-hexahvdro-f ll-benzopyranor3.4-c1pyrrol-2-yl .ethvn- rilbenzthienor3.2-d1pyrimidine-2.4(lH.3H)-dione hydrochloride Example 63A (±)-cis-7-Methoxy-1.2.3.3a.4.9b-hexahydro-[ll-benzopyrano[3.4-clpyπOle From 7-methoxy-coumarin and N-memoxymethyl-N-trimethylsilylmethyl-benzylamine in an analogous manner as described in Examples 1 A-C: 1H NMR (300 MHz, CDC13) δ 1.92 (br s, IH), 2.60 (m, IH), 2.81 (m, 2H), 3.17 (q, IH), 3.29 (dd, IH), 3.40 (dd, IH), 3.77 (s, 3H), 3.78 (t, IH), 4.10 (dd, IH), 6.43 (d, IH), 6.52 (dd, IH), 7.03 (d, IH). Example 63B 3-r2-(r±Vc ..-7-Methoxy-1.2.3.3a.4.9h-hexahvdro-πi-henzopvranor3.4-clpvrrol-2-vnethvll- rilbenzthienor3.2-dlpyrimidine-2.4(lH.3HVdione hydrochloride The product from Example 63A (0.41 g, 2.00 mmol), N-(2-Chloroethyl)-N'-[3-[(2- methoxycarbonyl)benzothienyl]]-urea (0.654 g, 2.00 mmol), prepared by die procedure described in Eur. J. Med. Chem., 28: 499-504 (1993), and ethyldiisopropylamine (0.44 mL, 2.5 mmol) were dissolved in DMSO (3 mL) and the reaction was heated to 100° C for 3h. The reaction was cooled to room temperamre and 10 mL water added. The product was collected by filtration, recrystalUzed from 50% aqueous DMF, and the resulting product treated with excess anhydrous HCl in ethanol. After addition of anhydrous ether, the title compound was collected to yield 0.337 g: m.p. 204-7°; ^ NMR (300 MHz, DMSO-d6) δ 2.75-2.9 (m, IH), 2.9-3.2 (m, 2H), 3.4-3.7 (m, 3H), 3.71 (s, 3H), 3.85-4.4 (m, 6H), 6.44 (dd, J=l, 6.57, m Hz, IH), 7.10 (d, IH), 7.56 (m, IH), 7.64 (m, IH), 8.12 (b, IH), 8.41 (d, IH), 12.68 (br s, IH); MS (DCI/NH3) m/e 450 (M+H)+; Analysis calc'd for C24H24CIN3O4S: C, 59.32; H, 4.98; N, 8.65; found: C, 59.06; H, 5.06; N, 8.45. Example 64 3-r3-((±Vc .γ-7-Methoxy-1.2.3.3a.4.9b-hexahydro-ril-benzopyranor3.4-clpyrrol-2-vDproρvn- rilbenzthienor3.2-d1pyrimidine-2.4(lH.3H -dione hydrochloride The product from Example 63A (0.41 g, 2.00 mmol), N-(3-Chloropropyl)-N'-[3-[(2- methoxycarbonyl)benzothienyl]]-urea (0.750 g, 2.20 mmol), prepared by the procedure described in Eur. J. Med. Chem., 28: 499-504 (1993), were treated as described in Example 63 to yield 0.296 g of the title compound: m.p. 220-2°; *H NMR (300 MHz, DMSO-d6) δ 1.95- 2.15 (m, 2H), 2.7-3.0 (m, 3H), 3.1-3.7 (m, 4H), 3.70 (s, 3H), 3.86 (m, IH), 3.91-4.17 (m, 4H), 6.42 (d, IH), 6.55 (dd, J=l, 7.56, t Hz, IH), 7.64 (t, IH), 8.11 (d, IH), 8.41 (d, IH), 12.59 (br s, IH); MS (DCI/NH3) m/e 464 (M+H)+; Analysis calc'd for C24H26C1N3O4S-1/2H2O: C, 58.99; H, 5.34; N, 8.25; found: C, 59.10; H, 5.25; N, 8.09. Example 65 3-r2-((±Ve .v-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-benzopyranor3.4-clpyrrol-2-vnethvn- [l]benzthienof3.2-d.pyrimidine-2.4(lH.3H)-dione hydrochloride Example 65A (±)-cis-9-Methoxy-1.2.3.3a.4.9h-hexahydro-ri1-benzopyranof3.4-clpyrrole From 5-metiιoxy-coumarin and N-medioxymethyl-N-trimethylsilylmethyl-benzylamine in an analogous manner as described in Examples lA-C. ^H NMR (300 MHz, CDCI3) δ 2.55 (m, IH), 2.67 (dd, IH), 2.80 (dd, IH), 3.21 (q, IH), 3.32 (dd, IH), 3.62 (dd, IH), 3.70 (m, IH), 3.81 (s, 3H), 4.10 (dd, IH), 6.46 (d, IH), 6.55 (d, IH), 7.17 (t, IH). Example 65B 3-r2- (( ± ) - -9-Methoxy-1.2.3.3a.4.9b-hexahydro-[n-benzopyranor3.4-c1pyrroI-2-yl)ethyll- rilbenzthienor3.2-d1pyrimidine-2.4(lH.3H)-dione hydrochloride The product from Example 65A (515 mg, 2.5 mmol), N-(2-Chloroethyl)-N'-[3-[(2- methoxycarbonyl)benzothienyl]]-urea (915 mg, 2.8 mmol), prepared by the procedure described in Eur. J. Med. Chem,, 28: 499-504 (1993), and ethyldiisopropylamine (1.0 mL) were treated as described in Example 63B to yield 0.200 g (18%) of the title compound, m.p.: 224-228°; l U NMR (300 MHz, CDCI3 (free base)) δ 2.40-2.53 (m, 2H), 2.56-2.68 (m, 1H), 2.81-3.01 (m, 2H), 3.30 (dd, J=7, 9 Hz, IH), 3.43 (q, J=8 Hz, IH), 3.58 (t, J=9 Hz, IH), 3.72 (s, 3H), 3.77 (dd, J=9, 11 Hz, IH), 4.02 (dd, J=5, 11 Hz, IH), 4.35 (t, J=7 Hz, 2H), 6.39 (d, J=8 Hz, IH), 6.49 (d, J=8 Hz, IH), 7.04 (t, J=8 Hz, IH), 7.40 (t, J=8 Hz, IH), 7.54 (t, J=8 Hz, IH), 7.88 (d, J=8 Hz, IH), 8.24 (d, J=8 Hz, IH); MS (CI(NH3)) m/e (M+H)+ at 450; Analysis calc'd for C24H23N3θ4S » HCl » (H2θ)o.5: C, 58.24; H, 5.09; N, 8.49; found: C, 57.90; H, 4.76; N, 8.24. Example 66 3-r3-(f+Vr/.γ-9-Methoxy-1.2.3.3a.4.9b-hexahydro-πi-benzopyranor3.4-c1pyrrol-2-vDpropyn- rilbenzthienor3.2-dlpyrimidine-2.4(lH.3HVdione hydrochloride The product from Example 65A (500 mg, 2.4 mmol), N-(3-Chloropropyl)-N'-[3-[(2- methoxycarbonyl)benzothienyl]]-urea (1.7 g, 5.0 mmol), prepared by the procedure described in Eur. J. Med. Chem., 28: 499-504 (1993), and ethyldiisopropylamine (1.0 mL) were treated as described in Example 63B to yield 300 mg (27 %) of the titie compound, m.p.: 197-199°; iH NMR (300 MHz, CD3OD) δ 2.08-2.20 (m, 2H), 2.87-3.01 (m, IH), 3.14-3.45 (m, 3H), 3.69 (q, J=8 Hz, IH), 3.77-3.87 (m, IH), 3.85 (s, 3H), 3.92 (dd, J=7, 12 Hz, IH), 4.02- 4.20 (m, 5H), 6.51 (dd, J=l, 8 Hz, IH), 6.58 (dd, J=l, 8 Hz, IH), 7.11 (t, J=8 Hz, IH), 7.54 (t, J=8 Hz, IH), 7.60-7.67 (m, IH), 7.99 (d, J=8 Hz, IH), 8.18 (d, J=8 Hz, IH); MS (CKNH3)) m/e (M+H)+ at 464; Analysis calc'd for C25H25N3θ4S « HCl « CH3θH: C, 58.69; H, 5.68; N, 7.90; found: C, 58.43; H, 5.23; N, 7.93. Example 67 3-r2-((±)-c .γ-6-Methoxy-1.2.3.3a.4.9b-hexahydro-ril-benzopyranor3.4-clpyrrol-2-yl)ethyll- llhen7.thienor3.2-dlpyrimidine-2.4(lH.3H)-dione hydrochloride Example 67 A (±)-cis-6-Methoxy-1.2.3.3a.4.9b-hexahydro-ril-henzoρyranor3.4-clpyrrole From 8-methoxy-coumarin and N-methoxymediyl-N-trimethylsilylmethyl-benzylamine in an analogous manner as described in Examples 1A-C. Example 67B 3-r2-rf±Ve/.γ-6-Methoxv-1.2.3.3a.4.9h-hexahvdro-ril-henzopvranor3.4-c1pyrrol-2-vnRthyll- rilhenzthienor3.2-d1pvrimidine-2.4(lH.3HVdione hydrochloride The product from Example 67 A (600 mg, 2.9 mmol), N-(2-Chloroethyl)-N'-[3-[(2- methoxycarbonyl)benzothienyl]]-urea (1.2 g, 3.7 mmol), prepared by the procedure described in Eur. J. Med. Chem., 28: 499-504 (1993), and ethyldiisopropylamine (1.5 mL) were treated as described in Example 63B to yield 320 mg (24 %) of the titie compound, m.p.: 251-254°; l U NMR (300 MHz, CDCI3 (free base)) δ 2.43-2.52 (m, 2H), 2.67-2.79 (m, IH), 2.90 (t, J=7 Hz, 2H), 3.32-3.45 (m, 2H), 3.51 (t, J=8 Hz, IH), 3.82 (dd, J=8, 11 Hz, IH), 3.85 (s, 3H), 4.13 (dd, J=5, 9 Hz, IH), 4.34 (t, J=7 Hz, 2H), 6.65-6.72 (m, 2H), 6.81 (t, J=8 Hz, IH), 7.39 (t, J=8 Hz, IH), 7.55 (t, J=8 Hz, IH), 7.88 (d, J=8 Hz, IH), 8.24 (d, J=8 Hz, IH); MS (CI(NH3)) m/e (M+H)+ at 450; Analysis calc'd for C24H23N3θ4S » HCl: C, 59.32; H, 4.98; N, 8.65; found: C, 59.18; H, 5.06; N, 8.54. Example 68 3-r3-((±V .γ-6-Methoxy-1.2.3.3a.4.9b-hexahvdro-rn-benzopyranor3.4-clpyrrol-2-yl)propyll- π]benzthienor3.2-d1pyrimidine-2.4 ( lH.3H.-dione hydrochloride The product from Example 67A (500 mg, 2.4 mmol), N-(3-Chloropropyl)-N'-[3-[(2- methoxycarbonyl)benzothienyl]]-urea (1.7 g, 5.0 mmol), prepared by the procedure described in Eur. J. Med. Chem,, 28: 499-504 (1993), and ethyldiisopropylamine (1.5 mL) were treated as described in Example 63B to yield 610 mg (54 %) of the titie compound, m.p.: 191-195°; iH NMR (300 MHz, CDCI3 (free base)) δ 1.95-2.07 (m, 2H), 2.20-2.34 (m, 2H), 2.57-2.74 (m, 3H), 3.21 (dd, J=8, 9 Hz, IH), 3.28-3.40 (m, 2H), 3.76 (dd, J=8, 11 Hz, IH), 3.83 (s, 3H), 4.10 (dd, J=5, 11 Hz, IH), 4.27 (t, J=7 Hz, 2H), 6.61-6.70 (m, 2H), 6.80 (t, J=8 Hz, IH), 7.47 (dd, J=l, 8 Hz, IH), 7.56 (dd, J=l, 8 Hz, IH), 7.88 (d, J=8 Hz, IH), 8.26 (d, J=8 Hz, IH); MS (CI(NH3)) m/e (M+H)+ at 464; Analysis calc'd for C24H25N3θ4S « HCl-(H2θ)0.25: C 59.52; H, 5.29; N, 8.33; found: C, 59.17; H, 5.22; N, 8.24. Example 69 3-r2-((±V γ-1.2.3.3a.4.9b-hexahvdro-πi-benzopyranor3.4-clpyrrol-2-yl.ethyll- ri1benzthienor3.2-dlpyrimidine-2.4(lH.3H)-dione hydrochloride Example 69 A (±)-cis- 1.2.3.3a.4.9h-hexahvdro-r 1 l-benzopyranor3.4-c .pyrrole From coumarin and N-methoxymethyl-N-trimethylsilylmethyl-benzylamine in an analogous manner as described in Examples 1A-C. Example 69B 3-r2-((±Vc..γ-1.2.3.3a.4.9h-hexahvdro-ril-henzopvranor3.4-clpvrrol-2-vl.ethvl1- f 1 Ibenzthienof 3.2-dlpyrimidine-2.4( 1 H.3H)-dione hydrochloride The product from Example 69A (540 mg, 2.8 mmol), N-(2-Chloroethyl)-N'-[3-[(2- methoxycarbonyl)benzothienyl]]-urea (0.89 g, 3.6 mmol), prepared by the procedure described in Eur. J. Med. Chem,, 28: 499-504 (1993) and ethyldiisopropylamine (1.5 mL) were treated as described in Example 63B to yield 410 mg (35 %) of the title compound, m.p.: 256-257°; iH NMR (300 MHz, CD3OD) δ 3.00-3.13 (m, IH), 3.23-3.70 (m, 3H), 3.58 (t, J=6 Hz, IH), 3.72-3.80 (m, IH), 3.87-4.20 (m, 2H), 4.03 (dd, J=6, 12 Hz, IH), 4.15 (dd, J=4, 12 Hz, IH), 4.41 (t, J=6 Hz, 2H), 6.89 (dd, J=l, 8 Hz, IH), 6.96-7.02 (m, IH), 7.18 (dt, J=2, 8 Hz, IH), 7.25 (dd, J=l, 8 Hz, IH), 7.51-7.58 (m, IH), 7.60-7.67 (m, IH), 7.99 (d, J=8 Hz, IH), 8.18 (d, J=8 Hz, IH); MS (CI(NH3)) m/e (M+H)+ at 420; Analysis calc'd for C23H2lN3θ3S « HCl: C, 60.59; H, 4.86; N, 9.22; found: C, 60.38; H, 4.83; N, 9.14. Example 70 3-r4-((±)-d.γ-1.2.3.3a.4.9h-hexahvdro-ril-benzopyrano[3.4-clpyrrol-2-yl)hutyl1- pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione dihydrochloride Example 70A (±)-c -2-(4-aminobutyl -1.2.3.3a.4.9b-hexahydro-r il-benzopyrano[3.4-clpyrrole The product from Example 69A (1.0 g, 5.71 mmol) was treated as described in Examples ID and IE to yield l.lg (98%) of the title compound: l U NMR (300 MHz, CDCI3) δ 1.4-1.8 (m, 6H), 2.20 (dd, IH), 2.27 (t, IH), 2.45 (m, 2H), 2.68-2.80 (m, 3H), 3.19 (dd, IH), 3.37 (m, 2H), 3.75 (dd, IH), 4.07 (dd, IH), 6.9 (m, 2H), 7.12 (m, IH). Example 70B 3-r4-((+V γ-1.2.3.3a.4.9b-hexahvdro-ril-henzopvranor3.4-clpyrrol-2-yl)butyll- pvridor2'.3':4.51thienor3.2-dlpyrimidine-2.4riH.3HVdione dihydrochloride The product from Example 70A (0.24g, lmmol) and methyl 3-amino-thieno[3,2- b]pyridine-2-carboxylate (0.30 g, 1.2 mmol) were treated as described in Example IF to yield 0.20 g (44 %) of the title compound: m.p. 203-205°; l U NMR (300 MHz, CDCl3(free base)) δ 8.78 (d, IH), 8.28 (d, IH), 8.48 (bs, IH), 7.52 (dd, IH), 7.13 (m, 2H), 6.92 (m, 2H), 4.08 (m, 4H), 3.92 (m, IH), 3.82 (m, IH), 3.68 (q, IH), 2.98 (m, 3H), 2.73 (m, 2H), 1.78 (m, 4H); MS (DCI/NH3) m/e 449(M+H)+; Analysis calc'd for C24H24N4O3S-2HC1-H2O: C, 53.43; H, 5.23; N, 10.39; found: C, 53.24; H, 4.83; N, 10.25. Example 71 3-r4-((±Vtrα«.y-1.2.3.3a.4.9h-hexahydro-ril-henzopyranor3.4-clpyrrol-2-yl)hutyll- pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione hydrochloride Example 71 A (± -trαn.γ-1.2.3.3a.4.9b-hexahydro-rn-benzopyranor3.4-clpyrrole Ethyl 2-methoxymethyl-cinnamate and N-methoxymethyl-N-trimethylsilylmethyl- benzylamine were treated, in an analogous manner as described in Examples 3A-C. Example 7 IB . ± . - Y-2-(4-aminohutylV 1.2.3.3a.4.9h-hexahvdro-r H-henzopvranor3.4-c1pvrrole The product from Example 71 A (1.22 g, 6.97 mmol) was treated as described in Examples ID and IE to yield 0.58 g (34%) of the title compound: l U NMR (300 MHz, CDCI3) δ 1.45-1.8 (m, 6H), 2.29 (m, IH), 2.60-2.83 (m, 6H), 2.95 (m, 2H), 3.39 (dd, IH), 4.12 (dd, IH), 4.50 (dd, IH), 6.83 (m, 2H), 6.91 (m, IH), 7.13 (m, IH). Example 71C 3-r4-((±Vtr < γ-1.2.3.3a.4.9b-hexahydro-ril-benzopyranor3.4-clpvrrol-2-vl.hutvll- pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H.-dione hydrochloride The product from Example 7 IB (0.24g, 1.0 mmol) and methyl 3-amino-thieno[3,2- b]pyridine-2-carboxylate (0.35 g, 1.35 mmol) were treated as described in Example IF to yield 0.18 g (38 %) of the title compound: m.p. >250°; 1H NMR (300 MHz, CDCl3(free base)) δ 8.78 (d, IH), 8.3 (bs, IH), 8.29 (d, IH), 7.53 (dd, IH), 7.18 (t, IH), 6.88 (m, 3H), 4.55 (dd, IH), 4.12 (m, 3H), 4.05 (m, IH), 3.51 (m, IH), 3.23 (m, 4H), 3.08 (m, IH), 2.48 (m, IH), 1.85 (m, 4H); MS (DCI/NH3) m/e 452(M+H)+; Analysis calc'd for C24H24N4O3S-HCI-O.5H2O: C, 58.35; H, 5.30; N, 11.34; found: C, 58.43; H, 4.97; N, 11.34. Example 72 3-r4-((±Vtrαn.γ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4-clpyrrol-2- yl .butyll-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione dihydrochloride Example 72A r±Vtrctn.γ-2-9-Methoxv-1.2.3.3a.4.9b-hexahvdro-rn-henzopyranor3.4-clpvrrole From ethyl 2-methoxy-6-metiιoxymetiιyl-cinnamate and N-methoxymethyl-N- trimethylsilylmethyl-benzylamine, in an analogous manner as described in Examples 3A-C: 1H NMR (300 MHz, CDCI3) δ 2.07 (br s, IH), 2.24 (m, IH), 2.70 (m, 2H), 2.84 (t, IH), 3.21 (dd, IH), 3.77 (s, 3H), 3.83 (dd, IH), 4.07 (dd, IH), 4.53 (dd, IH), 6.40 (d, IH), 6.51 (d, IH), 7.06 (t, IH). Example 72B (±)-trαrø-2-(4-aminobutyl)-9-Methoxy-1.2.3.3a.4.9b-hexahydro-[ll-henzopyranor3.4- clpyrrole The product from Example 72 A (1.2, 4.75 mmol) was treated as described in Examples 3D-E to yield 1.0 g (64%) of the title compound: *H NMR (300 MHz, CDCI3) δ 1.40-1.80 (m, 4H), 2.32 (m, IH), 2.57 (t, IH), 2.62-2.90 (m, 4H), 2.95 (t, IH), 3.60 (m, IH), 3.78 (s, 3H), 4.06 (dd, IH), 4.45 (dd, IH), 6.40 (d, IH), 6.49 (d, IH), 7.04 (t, IH). Example 72C 3-[4-((±)-tr Λ»'-9-Methoxy- 1.2.3.3a.4.9b-hexahydro-r ll-benzopyranor3.4-clpyrrol-2- yDbutyll-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione dihydrochloride The product from Example 72B (0.28 g, 1.0 mmol) and metiiyl 3-amino-thieno[3,2- b]pyridine-2-carboxylate (0.27 g, 1.15 mmol) were treated as described in Example IF to yield 0.22 g (46 %) of the title compound: m.p. >250°; l NMR (300 MHz, DMSO-d6 (free base)) δ 1.42-1.54 (m, 2H), 1.60-1.72 (m, 2H), 2.04-2.18 (m, IH), 2.25-2.89 (m, 4H), 3.10-3.48 (m, 3H), 3.68 (s, 3H), 3.95 (t, J=7 Hz, 2H), 4.02 (dd, J=10, 12 Hz, IH), 4.39 (dd, J=4, 10 Hz, IH), 6.39 (dd, J=l, 8 Hz, IH), 6.44 (dd, J=l, 8 Hz, IH), 7.01 (t, J=8 Hz, IH), 7.64 (dd, J=5, 8 Hz, IH), 8.63 (dd, J=l, 8 Hz, IH), 8.83 (dd, J=l, 5 Hz, IH); MS (DCI(NH3)) m/e 479 (M+H)+; Analysis calc'd for C25H26 4O4S-2HC1-0.5H2O: C, 53.57; H, 5.21; N, 10.00; found: C, 53.49; H, 5.35; N, 9.88. Example 73 3-r4-((±Vd.γ-9-Methoxv-1.2.3.3a.4.9h-hexahvdro-ril-benzopyranor3.4-clpyrrol-2-yl.hutyl1- pyridor2'.3':4.51thienol3.2-dlpyrimidine-2.4. 1H.3HVdione dihydrochloride Example 73A (±)-c/ -2-(4-aminobutyl)-9-Methoxy-1.2.3.3a.4.9h-hexahydro- ll-henzopyrano[3.4-c1pyrrole From 5-methoxycoumarin and N-medioxymemyl-N-trimethylsilylmethyl-benzylamine, in an analogous manner as described in Examples 1A-C: H NMR (300 MHz, CDCI3) δ 2.55 (m, IH), 2.67 (dd, IH), 2.80 (dd, IH), 3.21 (q, IH), 3.32 (dd, IH), 3.62 (dd, IH), 3.70 (m, IH), 3.81 (s, 3H), 4.10 (dd, IH), 6.46 (d, IH), 6.55 (d, IH), 7.17 (t, IH). Example 73B (±Vd5 , -2-(4-aminohutyl)-9-Methoxy-1.2.3.3a.4.9b-hexahydro- ll-benzopyranor3.4-clpyrrole The product from Example 73 A (0.2, 1.0 mmol) was treated as described in Examples 1D-E to yield 0.08 g (29%) of the title compound: *H NMR (300 MHz, CDCI3) δ 1.65-1.80 (m, 4H), 2.19 (m, IH), 2.25 (dd, IH), 2.42 (m, IH), 2.52 (t, 2H), 3.14 (dd, IH), 3.18-3.30 (m, 2H), 3.79 (dd, IH), 3.80 (s, 3H), 4.04 (dd, IH), 6.46 (d, IH), 6.54 (d, IH), 7.07 (t, IH). Example 73C 3-r4-((±)-c .γ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4-clpyrrol-2-vl .hutvll- pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione dihydrochloride The product from Example 73B (0.28 g, 1.0 mmol) and methyl 3-amino-thieno[3,2- b]pyridine-2-carboxylate (0.27 g, 1.15 mmol) were treated as described in Example IF to yield 0.20 g (42 %) of the title compound: m.p. 198-200°; l U NMR (300 MHz, CDCI3 (free base)) δ 1.56-1.99 (m, 2H), 1.71-1.83 (m, 2H), 2.26 (t, J=9 Hz, IH), 2.34 (dd, J=6, 10 Hz, IH), 2.50-2.70 (m, 3H), 3.26 (dd, J=7, 10 Hz, IH), 3.43 (q, J=8 Hz, IH), 3.63 (t, J=8 Hz, IH), 3.79 (s, 3H), 3.76-3.86 (m, IH), 4.01 (dd, J=4, 11 Hz, IH), 4.11 (t, J=7 Hz, IH), 6.43 (d, J=8 Hz, IH), 6.49 (d, J=8 Hz, IH), 7.04 (t, J=8 Hz, IH), 7.49 (dd, J=4, 8 Hz, IH), 8.23 (dd, J=l, 8 Hz, IH), 8.78 (dd, J=l, 4 Hz, IH); MS (DCI/NH3) m/e 479(M+H)+; Analysis calc'd for C25H26N4O4S-2HC1-0.5H2O: C, 53.57; H, 5.21; N, 10.00; found: C, 53.41; H, 5.24; N, 9.88. Example 74 3-r4-((±Vtrαn.v-9-Methoxv-1.2.3.3a.4.9h-hexahvdro-ri1-henzopvranor3.4-clpyrrol-2- vl.hutvll-pvrazinor2'.3':4.51thienor3.2-d1pyrimidine-2.4(lH.3HVdione dihydrochloride Etiiyl 7-amino-thieno[2,3-b]pyrazine-6-carboxylate ( 0.25 g, 1.0 mmol) prepared by the method of Schneller and Clough, J. Het. Chem,, 12: 513 (1975) and the product from Example 72B (0.28 g, 1.0 mmol) were treated as described in Example IF to yield 0.18 g (38%) of the title compound: m.p. 193-195°; l U NMR (300 MHz, DMSO-d6(free base)) δ 8.98 (d, IH), 8.89 (d, IH), 7.11 (t, IH), 6.52 (d, IH), 6.45 (d, IH), 4.5 (dd, IH), 4.2 (m, IH), 4.1 (m, IH), 3.92 (m, 2H), 3.73 (s, 3H), 3.0 (m, IH), 2.6 (m, 5H), 2.3 (m, IH), 1.8 (m, 4H); MS (DCI/NH3) m/e 4809(M+H)+; Analysis calc'd for C24H25N5SO4.2HCl.2H2O: C, 48.98; H, 5.31; N, 11.90; found: C, C48.48; H, 5.80; N, 11.94. Example 75 3-r4-((± -d.γ-8-Methoxy-1.2.3.3a.4.9h-hexahydro-ril-benzopyranor3.4-c1pyrrol-2-yl.hutyll- pyridor3'.2':4.51thienor3.2-dlpyrimidine-2.4(lH.3H -dione dihydrochloride Example 75A (±)-d^-2-8-Methoxy-1.2.3.3a.4.9b-hexahydro-[ll-benzopyranor3.4-clpyrrole From 6-methoxycoumarin and N-methoxymethyl-N-trimethylsilylmethyl-benzylamine, in an analogous manner as described in Examples lA-C. Example 75B (±)-c^-2-(4-aminohutyl)-8-Methoxy-1.2.3.3a.4.9b-hexahydro-[ll-benzopyranor3.4-clpyrrole The product from Example 75 A (l.Og, 4.9 mmol) was treated as described in Examples 1D-E to yield 0.72 g (54%) of the title compound. Example 75C 3-r4-r(±Vd.γ-8-Methoxy-1.2.3.3a.4.9h-hexahvdro-rn-henzopyranor3.4-clpyrrol-2-yl .huty - pvridor3'_2':4.51thienor3.2-dlpvrimidine-2.4πH.3H.-dione dihydrochloride Methyl 3-amino-thieno[2,3-b]pyridine-2-carboxylate (0.25 g, 1.07 mmol) and the product from Example 75B (0.26 g, 1.0 mmol) were treated as described in Example IF to yield 0.20 g (46%) of the title compound: m.p. 203-204°; ^U NMR (300 MHz, CDCl3(free base)) δ 8.72 (dd, IH), 8.6 (d, IH), 8.38 (bs, IH), 7.41 (dd, IH), 6.82 (d, IH), 6.71 (dd, IH), 6.6 (d, IH), 4.12 (m, 4H), 3.98 (m, 2H), 3.78 (m, IH), 3.73 (s, 3H), 3.12 (m, 2H), 3.05 (m, IH), 2.92 (m, IH), 2.85 (m, IH), 1.82 (m, 4H); MS (DCI/NH3) m/e 479(M+H)+; Analysis calc'd for C25H26N4O4S-2HC1-0.5H2O: C, 53.57; H, 5.22; N, 10.00; found: C, 53.81; H, 5.06; N, 9.91. Example 76 3-r4-((+)-d_.-8-Methoxy-1.2.3.3a.4.9b-hexahydro-ril-benzopyranor3.4-c1pyrrol-2-yl)butyll- pyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4(TH.3HVdione hydrochloride Etiiyl 7-amino-thieno[2,3-b]pyrazine-6-carboxylate ( 0.25 g, 1.05 mmol) prepared by the method of Schneller and Clough, J. Het. Chem., 12: 513 (1975) and the product from Example 75B (0.28 g, 1.0 mmol) were treated as described in Example IF to yield 0.30 g (62%) of the title compound: m.p. 218-220°; U NMR (300 MHz, CDCl3(free base)) δ 8.72 (m, 2H), 6.8 (d, IH), 6.68 (dd, IH), 6.61 (d, IH), 4.12 (t, 2H), 4.0 (dd, IH), 3.82 (m, IH), 3.75 (s, 3H), 3.58 (m, 3H), 2.89 (m, IH), 2.79 (m, 2H), 2.52 (m, 2H), 1.75 (m, 4H); MS (DCI/NH3) m/e 480(M+H)+; Analysis calc'd for C24H25N5O4S-HC1-2H2O: C, 52.22; H, 5.48; N, 12.69; found: C, 52.68; H, 5.22; N, 12.63. Example 77 3-r3-((±)-d.γ-8-Methoxy-1.2.3.3a.4.9b-hexahvdro-πi-henzopyranor3.4-clpyrrol-2-vDpropyn- pyridor3'.2':4.51thienor3.2-dlpyrimidine-2.4riH.3HVdione hydrochloride Example 77A .+Vd.γ-2- ( 3-aminoproρyn-8-Methoxv-1.2.3.3a.4.9b-hexahvdro-ril-henzopyranor3.4- clpyrrole The product from Example 75A (1.26 g, 6.14 mmol) was treated with 0.61 mL (7.36 mmol) 3-bromopropionitrile, foUowed by LiAlH4 and AICI3 in an analagous manner as described in Examples 1D-E to yield 0.85 g (52%) of title compound. Example 77B 3-r3-(f+.-d.γ-8-Methoxv-1.2.3.3a.4.9h-hexahvdro-ril-benzopvranor3.4-c1pvrrol-2-vl.propvll- pyridor3'.2':4.51thienor3.2-dlpyrimidine-2.4(lH.3H.-dione hydrochloride Methyl 3-amino-thieno[2,3-b]pyridine-2-carboxylate (0.25 g, 1.07 mmol) and the product from Example 78A (0.26 g, 1.0 mmol) were treated as described in Example IF to yield 0.23 g (50%) of the title compound: l U NMR (300 MHz, CDCl3(free base)) δ 8.64 (dd, IH), 8.43 (dd, IH), 8.45 (s, IH), 7.32 (dd, IH), 6.82 (d, IH), 6.7 (dd, IH), 6.61 (d, IH), 4.2 (m, IH), 4.13 (t, 2H), 3.98 (m, 3H), 3.73 (m, IH), 3.72 (s, 3H), 3.22 (m, 2H), 3.0 (m, IH), 2.95 (d, IH), 2.85 (m, IH), 2.48 (m, 2H); MS (DCI/NH3) m/e 465(M+H)+; Analysis calc'd for C24H24N4O4S-HC1-H2O: C, 55.54; H, 5.24; N, 10.79; found: C, 55.18; H, 4.98; N, 10.63. Example 78 3-r2-((±Vd.γ-8-Methoxy-1.2.3.3a.4.9b-hexahvdro-ril-henzopyranor3.4-clpyrrol-2-vnethyll- pyridor3'.2':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione hydrochloride Example 78 A (±)-d.y-2-(2-aminoethyl)-8-Methoxy-1.2.3.3a.4.9b-hexahydro- l]-benzopyrano[3.4-clpyrrole The product from Example 75A (1.0 g, 4.88 mmol) was treated with 0.34 mL (5.36 mmol) 2-chloroacetonitrile, followed by LiAlH4 and AICI3 in an analagous manner as described in Examples 1D-E to yield 0.72 g (59%) of title compound: l U NMR (300 MHz, CDCI3) δ 2.1 (br s, 2H), 2.25-2.45 (m, 2H), 2.52-2.65 (m, 2H), 2.72 (m, IH), 2.83 (t, 2H), 3.17 (dd, IH), 3.28-3.45 (m, 2H), 3.75 (dd, IH), 3.77 (s, 3H), 4.01 (dd, IH), 6.63 (d, IH), 6.68 (dd, IH), 6.81 (d, IH). Example 78B 3-r2-((±Vdγ-8-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4-clnyrro1-2-v1.ethvn- pvridor3'.2':4.51thienor3.2-d1pvrimidine-2.4. 1H.3HVdione hydrochloride Methyl 3-amino-thieno[2,3-b]pyridine-2-carboxylate (0.25 g, 1.07 mmol) and the product from Example 78A (0.25 g, 1.0 mmol) were treated as described in Example IF to yield 0.20 g (44%) of the title compound: 1H NMR (300 MHz, CDCl3(free base)) δ 8.7 (dd, IH), 8.48 (dd, IH), 8.3 (bs, IH), 7.32 (dd, IH), 6.81 (d, IH), 6.7 (dd, IH), 6.65 (d, IH), 4.5-4.7 (m, 3H), 4.0 (m, 3H), 3.76 (s, 3H), 3.4 (m, 2H), 3.1 (m, 2H), 2.9 (m, 2H); MS (DCI7NH3) m/e 451(M+H)+; Analysis calc'd for C23H22N4O4S HCI O.5H2O: C, 55.70; H, 4.88; N, 11.30; found: C, 55.61; H, 4.66; N, 11.19. Example 79 3-r4-((±)-d -9-Methoxy-1.2.3.3a.4.9b-hexahydro-[ll-benzopyrano .4-clpyrrol-2-yl)butyIl- 6.7-dimethoxy-quinazohne-2.4( 1 H.3H)-dione hydrochloride Methyl 2-amino-4,5-dimethoxybenzoate (0.28 g, 1.18 mmol) and the product from Example 73 A (0.28 g, 1.0 mmol) were treated as described in Example IF to yield the intermediate urea, which was treated with 1.5 mL of 1.0M KOtBu in 20 mL THF to yield the title compound (0.19 g, 40%): m.p. 178-180° (dec); NMR (300 MHz, CDCl3(free base)) δ 7.44 (s, IH), 7.06 (t, IH), 6.48 (m, 2H), 6.42 (s, IH), 4.06 (m, 3H), 4.0 (m, IH), 3.95 (s, 3H), 3.92 (s, 3H), 3.83 (m, IH), 3.8 (s, 3H), 3.48 (m, IH), 3.2 (m, IH), 2.58 (m, 3H), 2.3 (m, 2H), 1.75 (m, 2H), 1.65 (m, 2H); MS (DCI/NH3) m/e 482(M+H)+; Analysis calc'd for C26H31N3O6-HC1-2H2O: C, 56.37; H, 6.55; N, 7.58; found: C, 56.61; H, 6.30; N, 7.47. Example 80 3-r4-((±)-tr_7 -1.2.3.3a.4.9h-hexahvdro-πi-benzopyranof3.4-clpyrrol-2-ynhutvn-6.7- dimethoxy-quinazoline-2.4( 1 H.3HVdione hydrochloride Methyl 2-amino-4,5-dimethoxybenzoate (0.27 g, 1.15 mmol) and die product from Example 7 IB (0.25 g, 1.0 mmol) were treated as described in Example IF to yield me intermediate urea, which was treated with 1.5 mL of 1.0M KOtBu in 20 mL THF to yield the title compound (0.12 g, 26%): m.p. 182-184°; *H NMR (300 MHz, CDCl3(free base)) δ 7.41 (s, IH), 7.18 (m, IH), 6.88 (s, IH), 6.86 (m, 2H), 6.71 (s, IH), 4.55 (dd, IH), 4.18 (t, IH), 4.08 (t, 2H), 3.95 (s, 3H), 3.91 (s, 3H), 3.9 (m, IH), 3.48 (m, IH), 3.22 (m, 4H), 3.08 (m, IH), 2.5 (m, IH), 1.82 (m, 4H); MS (DCI/NH3) m/e 452(M+H)+; Analysis calc'd for C25H29N3O5-HC1-H2O: C, 59.34; H, 6.37; N, 8.32; found: C, 59.12; H, 6.21; N, 7.82. Example 81 3-r4-r ( +Vd. γ -1.2.3.3a.4.9h-hexahvdro-ril-benzopyranor3.4-c1pyrrol-2-yl.hutyl1-6.7- dimethoxy-quinazoline-2.4(lH.3H)-dione hydrochloride Methyl 2-amino-4,5-dimethoxybenzoate (0.27 g, 1.15 mmol) and the product from Example 70 A (0.25 g, 1.0 mmol) were treated as described in Example IF to yield the intermediate urea, which was treated with 1.5 mL of 1.0M KOtBu in 20 mL THF to yield die title compound (0.18 g, 39%): 1H NMR (300 MHz, CDCl3(free base)) δ 8.3 (b s, IH), 7.46 (s, IH), 7.08 (m, 2H), 6.88 (m, 2H), 6.39 (s, IH), 4.08 (m, 3H), 3.96 (s, 3H), 3.94 (s, 3H), 3.72 (m, IH), 3.38 (m, 2H), 3.21 (m, IH), 2.72 (m, IH), 2.52 (m, 2H), 2.28 (m, 2H), 1.75 (m, 2H), 1.62 (m, 2H); MS (DCI/NH3) m/e 452(M+H)+; Analysis calc'd for C25H29N3O5-HC1-2H2O: C, 57.19; H, 6.1; N, 8.00; found: C, 56.63; H, 6.08; N, 7.51. Example 82 3-r4-((±.-trα».γ-9-Methoxy-1.2.3.3a.4.9h-hexahydro-ril-henzopyranor3.4-c1pyrrol-2- yDbutyll -6.7-dimethoxy-quinazoline-2.4( 1 H.3H)-dione dihydrochloride Methyl 2-amino-4,5-dimethoxybenzoate (0.28 g, 1.18 mmol) and the product from Example 72A (0.28 g, 1.0 mmol) were treated as described in Example IF to yield the intermediate urea, which was treated with 1.5 mL of 1.0M KOtBu in 20 mL THF to yield the title compound (0.38 g, 79%): m.p. 189-191°; l U NMR (300 MHz, CDCl3(free base)) δ 7.44 (s, IH), 7.05 (t, IH), 6.49 (d, IH), 6.41 (s, IH), 6.39 (d, IH), 4.44 (dd, IH), 4.1 (m, 3H), 3.96 (s, 3H), 3.93 (s, 3H), 3.76 (s, 3H), 3.6 (m, IH), 2.99 (t, IH), 2.78 (m, 4H), 2.58 (t, IH), 2.3 (m, IH), 1.75 (m, 2H), 1.65 (m, 2H); MS (DCI/NH3) m/e 482(M+H)+; Analysis calc'd for C26H3lN3θ6-2HCl-2H2θ: C, 52.89; H, 6.32; N, 7.12; found: C, 52.89; H, 5.99; N, 7.02. Example 83 3-[3-((±)-trfl/ι_.-10-Methoxy-1.3.4.4a.5.10h-hexahydro-2H-πi-benzopyrano[ " 3.4-clpyrido-3- yl)propyll-6.7-dimethoxy-quinazoline-2.4. 1 H.3H)-dione hydrochloride Example 83A ■ ±Vtrαn.γ-N-benzvl-3-carhoethoxv-4-( ' 2-methoxv-6-met.hoxymethyl.phenyl-piperidine-2.5- dione Ethyl 2-methoxy-6-methoxymethyl-cinnamate (13.2 g, 59.7 mmol) was treated with ethyl N-benzylamidomalonate according to the method of Faruk and Martin, U. S. Patent No. 4,902,801, to yield the titie compound (8.34 g, 38%). l U NMR (300 MHz, DMSO) δ 7.47- 7.24 (m, 5H), 7.19 (dd, IH), 6.71 (d, IH), 6.68 (d, IH), 5.19 (dd, 2H), 4.88 (s, 2H), 4.70 (d, 2H), 4.25 (dt, IH), 3.90 (dq, 2H), 3.78 (s, 3H), 3.41 (dd, IH), 3.40 (s, 3H), 2.63 (dd, IH), 0.87 (t, 3H). MS (DCI/NH3) m/e 442 (M+H)+. Example 83B (+)-tr n^-N-benzyl-3-chloromethyl-4-(2-hydroxy-6-methoxy)phenyl-piperidine To a solution of LiAlH4 (2.45 g, 64.6 mmol) in THF (250 mL) was added dropwise at 0°C a solution of the product from Example 83A (9.50 g, 21.5 mmol) in THF (50 mL). The reaction was warmed to room temperature, and then refluxed for 3 hours. The reaction was cooled to 0°C and quenched by the consecutive addition of water (4 mL), 1M NaOH (4 mL), and water (10 mL), and stirred for 1 hour. The mixture was filtered through a pad of Celite and rinsed with EtOAc (500 mL). The organic layer was dried over MgSO4, and condensed in vacuo to yield 8.0 g of a clear oil. The oU was taken up in methanol (250 mL) and concentrated HCl (15 mL) and stirred at reflux for 6 hours. The mixture was cooled, condensed in vacuo, and the residue was partitioned between EtOAc and a saturated solution of NaHCC>3. The layers were separated and the aqueous layer extracted with 2x EtOAc. The combined organic layers were dried over MgSO4, and condensed in vacuo to yield 7.0 g of a clear oil. To a solution of this oU in CCI4 (75 mL) and CH3CN (75 mL) was added triphenylphosphine (11.3 g, 43.1 mmol), and the solution was refluxed for 1 hour. The mixture was cooled and condensed in vacuo, and the residue was chromatographed on Siθ2 using NH3-saturated 35% EtOAc/hexanes to yield the title compound (5.30 g, 71%). 1H NMR (300 MHz, DMSO) δ 9.32 (br s, IH), 7.35-7.22 (m, 5H), 6.96 (dd, IH), 6.44 (br d, 2H), 3.72 (s, 3H), 3.51 (dd, 2H), 3.26 (m, IH), 3.16 (m, 2H), 2.98 (dt, IH), 2.85 (m, 2H), 2.24 (m, IH), 1.93 (m, IH), 1.78 (m, IH), 1.39 (m, IH). MS (DCI/NH3) m/e 346 (M+H)+. Example 83C (±.-trfln.γ-10-Methoxy-1.3.4.4a.5.10h-hexahydro-2H-ril-henzopyranor3.4-c1pyridinς; To a solution of the product from Example 83B (5.30 g, 15.3 mmol) in THF (125 mL) 5 was added a l.OM solution of potassium t-butoxide (16 mL), and the reaction was refluxed for 2 hours. The reaction was cooled, poured into water, and extracted with 3x EtOAc. The extracts were dried over MgSO4, and condensed in vacuo to yield 4.7 g of a clear oil. To a solution of the oU and 10% Pd on carbon (2 g) in MeOH (125 mL) was added ammonium formate (4.7 g, 75 mmol), and the reaction was refluxed for 2 h. The reaction mixture was o cooled, filtered through a small pad of CeUte, and rinsed with EtOAc (200 mL). The filtrate was dried over Na2SO4, and condensed in vacuo to yield the title compound (3.01 g, 90%). iH NMR (300 MHz, DMSO) δ 7.02 (dd, IH), 6.48 (d, IH), 6.36 (d, IH), 4.03 (dd, IH), 3.72 (s, 3H), 3.55 (dd, IH), 3.01 (m, IH), 2.94 (dd, IH), 2.83 (ddd, IH), 2.62 (dt, IH), 2.51 (dt, IH), 2.29 (t, IH), 1.64 (ddt, IH), 1.05 (ddd, IH). MS (DCI/NH3) m e 220 5 (M+H)+. Example 83D (±Vtrαn.γ-3-(2-CvanoethylV10-Methoxy-1.3.4.4a.5.10b-hexahydro-2H-ri1-henzopvranor3.4- ςl pyridine 0 A mixture of the product from Example 83C (340 mg, 1.55 mmol), 3- bromopropionitrile (193 μL, 2.33 mmol), and ethyldiisopropylamine (675 μL, 3.88 mmol) in acetonitrile (4 mL) was refluxed for 18 hours. The reaction was cooled, and partitioned between EtOAc and 1M NaOH. The organic layer was dried over MgSO4, the solvent was 5 condensed in vacuo, and the crude product was chromatographed on Siθ2 using EtOAc to yield the title compound (0.335 g, 79%). ^ NMR (300 MHz, DMSO) δ 7.03 (dd, IH), 6.49 (d, IH), 6.38 (d, IH), 4.08 (dd, IH), 3.73 (s, 3H), 3.62 (t, IH), 3.04-2.86 (m, 3H), 2.65 (m, 4H), 2.41 (m, IH), 2.16 (m, IH), 1.81 (m, 2H), 1.18 (m, IH). MS (DCI/NH3) m/e 273 (M+H)+. 0 Example 83E (±Vtrα/7..-3-(3-AminopropylV10-Methoxy-1.3.4.4a.5.10b-hexahvdro-2H-ril- benzopyrano.3.4-c .pyridine 5 The product from Example 83D (355 mg, 1.30 mmol) was treated with 7.5 equivalents of LiAlH4 and 2.5 equivalents of AICI3 by the procedure described in Example IE to yield die title compound (0.347 g, 96%). l U NMR (300 MHz, DMSO) δ 7.02 (dd, IH), 6.48 (d, IH), 6.37 (d, IH), 4.08 (dd, IH), 3.73 (s, 3H), 3.62 (t, IH), 2.96 (m, 2H), 2.89 (m, IH), 2.57 (m, 2H), 2.39 (m, IH), 2.33 (m, 2H), 2.01 (dt, IH), 1.77 (m, IH), 1.66 (t, IH), 1.51 (m, 2H), 1.17 (m, IH). MS (DCI/NH3) m/e 277 (M+H)+. Example 83F 3-r3-fr±)-trαn.γ-10-Methoxy-1.3.4.4a.5.10h-hexahydro-2H-ri1-henzopyranor3.4-c1pyrido-3- vl.propvn-6.7-dimethoxv-quinazoUne-2.4flH.3HVdione hydrochloride Methyl 2-amino-4,5-dimethoxybenzoate (258 mg, 1.09 mmol) and die product from Example 83E (250 mg, 0.905 mmol) were treated as described in Example IF to yield die title compound (347 mg, 71%): m.p. 230°C. *H NMR (300 MHz, DMSO) δ 11.35 (s, IH), 10.61 (br s, IH), 7.31 (s, IH), 7.08 (t, IH), 6.74 (s, IH), 6.54 (d, IH), 6.42 (d, IH), 4.13 (dd, IH), 3.98 (m, 2H), 3.84 (s, 3H), 3.81 (s, 3H), 3.75 (s, 3H), 3.63 (m, IH), 3.58 (m, 2H), 3.10 (m, 4H), 2.84 (m, IH), 2.76 (m, IH), 2.24 (m, IH), 2.19 (m, 2H), 1.57 (m, IH). MS (DCI/NH3) m/e 482 (M+H)+. Anal calcd for C26H31N3O6T.6HCI: C, 57.85; H, 6.09; N, 7.78. Found: C, 57.73; H, 5.99; N, 7.57. Example 84 3-r3-((±V_rαn.γ-10-Methoxy-1.3.4.4a.5.10h-hexahvdro-2H-ril-benzopyranor3.4-clpyrido-3- yl)propyl1-pyridor3'.2':4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione hydrochloride Methyl 3-amino-thieno[2,3-b]pyridine-2-carboxylate (254 mg, 1.09 mmol) and the product from Example 83E (250 mg, 0.904 mmol) were treated as described in Example IF to yield the title compound (281 mg, 59%). m.p. >300°C. l U NMR (300 MHz, DMSO) δ 12.80 (s, IH), 10.44 (br s, IH), 8.83 (d, IH), 8.78 (d, IH), 7.67 (dd, IH), 7.09 (t, IH), 6.53 (d, IH), 6.42 (d, IH), 4.14 (dd, IH), 4.03 (m, 2H), 3.76 (s, 3H), 3.64 (m, IH), 3.59 (m, 2H), 3.24-3.02 (m, 4H), 2.85 (m, IH), 2.76 (m, IH), 2.22 (m, IH), 2.13 (m, 2H), 1.53 (m, IH). MS (DCI/NH3) m/e 479 (M+H)+. Anal calcd for C25H26N4O4S I.35HCI: C, 56.89; H, 5.22; N, 10.62. Found: C, 57.03; H, 5.06; N, 10.45. Example 85 3-[4-((±)-?rα , -10-Methoxy-1.3.4.4a.5.10b-hexahydro-2H-πi-benzopyrano[3.4-clpyrido-3- ynhutyll-pyridor3'.2':4.51thienor3.2-d1pyrimidine-2.4(lH.3H)-dione dihydrochloride Example 85A (±Vtr^γ-3-(3-CyanopropylV10-Methoxy-1.3.4.4a.5.10h-hexahydro-2H-ri]- henzopvranor3.4-c1pvridine 5 The product from Example 83C (380 mg, 1.73 mmol) was treated with 1.5 equivalents of 4-bromobutyronitrile and 2.5 equivalents of ethyldusopropylamine by the procedure described in Example 83D to yield the title compound (0.38 g, 71%). l NMR (300 MHz, DMSO) δ 7.03 (dd, IH), 6.49 (d, IH), 6.38 (d, IH), 4.09 (dd, IH), 3.73 (s, 3H), 3.62 (t, IH), 2.93 (m, 3H), 2.39 (m, 2H), 2.08 (m, IH), 1.74 (m, 3H), 1.30 (m, IH). MS o (DCI/NH3) m/e 287 (M+H)+. Example 85B (±Vtrαn.γ-3-(4-Aminobutyl)-10-Methoxy-1.3.4.4a.5.10b-hexahydro-2H-rn-henzopvranor3.4- clpyridine 5 The product from Example 85A (380 mg, 1.33 mmol) was treated with 7.5 equivalents of LiAlH4 and 2.5 equivalents of AICI3 by the procedure described in Example 83E to yield the title compound (0.358 g, 93%). NMR (300 MHz, DMSO) δ 7.02 (dd, IH), 6.48 (d, IH), 6.37 (d, IH), 4.08 (dd, IH), 3.73 (s, 3H), 3.62 (t, IH), 2.97 (m, 2H), 2.89 (m, IH), 2.53 0 (m, 2H), 2.38 (m, IH), 2.29 (m, 2H), 2.01 (dt, IH), 1.78 (m, IH), 1.67 (t, IH), 1.46 (m, 2H), 1.34 (m, 2H), 1.18 (m, IH). MS (DCI/NH3) m/e 291 (M+H)+. Example 85C 3-r4-((±)-trαn -10-Methoxy-1.3.4.4a.5.10b-hexahvdro-2H-ril-henzopyranor3.4-c1pyrido-3- 5 yl butyll-pyridor3'.2':4.51thienor3.2-dlpyrimidine-2.4dH.3H.-dione dihydrochloride Methyl 3-amino-thieno[2,3-b]pyridine-2-carboxylate (0.194 g, 1.09 mmol) and the product from Example 85B (0.200 g, 0.69 mmol) were treated as described in Example IF to yield the title compound (0.245 g, 59%): m.p. 251-4°C; l U NMR (300 MHz, DMSO) δ 12.72 0 (s, IH), 10.76 (br s, IH), 8.77 (d, IH), 8.74 (d, IH), 7.61 (dd, IH), 7.04 (t, IH), 6.50 (d, IH), 6.38 (d, IH), 4.12 (dd, IH), 3.92 (t, 2H), 3.71 (s, 3H), 3.62 (t, IH), 3.52 (m, 2H), 3.06 (m, 4H), 2.78 (m, 2H), 2.25 (m, IH), 1.76 (m, 2H), 1.64 (m, 2H), 1.54 (m, IH). MS (DCI/NH3) m/e 493 (M+H)+. Anal calcd for C26H28N404S-2HC1: C, 51.88; H, 5.19; N, 9.31. Found: C, 52.24; H, 5.52; N, 9.32. 5 Example 86 3-r4-f(±)-trαn.γ-10-Methoxy-1.3.4.4a.5.10h-hexahvdro-2H-m-henzopyranor3.4-c1pyridn-3- vDbutvll-6.7-dimethoxv-quinazoline-2.4(lH.3HVdione hydrochloride Methyl 2-amino-4,5-dimethoxybenzoate (0.196 g, 0.83 mmol) and die product from Example 85B (0.200 g, 0.69 mmol) were treated as described in Example IF to yield the title compound (0.140 g, 37%): m.p. 220°C. l U NMR (300 MHz, DMSO) δ 11.27 (s, IH), 10.54 (br s, IH), 7.25 (s, IH), 7.04 (t, IH), 6.68 (s, IH), 6.50 (d, IH), 6.39 (d, IH), 4.12 (dd, IH), 3.87 (t, 2H), 3.79 (s, 3H), 3.76 (s, 3H), 3.71 (s, 3H), 3.62 (t, IH), 3.62 (m, 2H), 3.06 (m, 4H), 2.76 (m, 2H), 2.21 (m, IH), 1.71 (m, 2H), 1.59 (m, 2H), 1.51 (m, IH). MS (DCI/NH3) m/e 496 (M+H)+. Anal calcd for C27H33N3O6-I.4HCI: C, 59.37; H, 6.35; N, 7.69. Found: C, 59.36; H, 6.56; N, 7.57. Example 87 3-r4-r(±Vtrfln.γ-10-Methoxy-1.3.4.4a.5.10h-hexahvdro-2H-ril-henzopyranor3.4-c1pvrido-3- yl.hutvn-rilhenzthienor3.2-d1pyrimidine-2.4(lH.3HVdione hydrochloride Methyl 3-amino-benzo[b]thiophene-2-carboxylate (0.143 g, 58 mmol) and the product from Example 85B (0.14 g, 0.48 mmol) were treated as described in Example IF to yield the title compound (0.121 g, 48%): m.p. >305°C. l U NMR (300 MHz, DMSO) δ 12.56 (s, IH), 10.44 (br s, IH), 8.37 (d, IH), 8.07 (d, IH), 7.60 (t, IH), 7.52 (t, IH), 7.04 (t, IH), 6.50 (d, IH), 6.38 (d, IH), 4.12 (dd, IH), 3.93 (t, 2H), 3.71 (s, 3H), 3.62 (t, IH), 3.53 (m, 2H), 3.06 (m, 4H), 2.77 (m, 2H), 2.20 (m, IH), 1.76 (m, 2H), 1.65 (m, 2H), 1.52 (m, IH). MS (DCI/NH3) m/e 492 (M+H)+. Anal calcd for C27H29N3O4S-HC1: C, 61.41; H, 5.73; N, 7.96. Found: C, 61.16; H, 5.48; N, 7.79. Example 88 3-r4-((±)-trαn.γ-10-Methoxy-1.3.4.4a.5.10b-hexahydro-2H-[ll-benzopyrano 3.4-c1pyrido-3- vnbutyll-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4πH.3H)-dione hydrochloride Methyl 3-amino-thieno[3,2-b]pyridine-2-carboxylate (0.135 g, 0.58 mmol) and die product from Example 85B (0.14 g, 0.48 mmol) were treated as described in Example IF to yield the titie compound (0.15 g, 54%): m.p. >325°C. *H NMR (300 MHz, DMSO) δ 12.68 (s, IH), 10.65 (br s, IH), 8.85 (d, IH), 8.66 (d, IH), 7.68 (dd, IH), 7.09 (t, IH), 6.54 (d, IH), 6.42 (d, IH), 4.17 (dd, IH), 3.97 (t, 2H), 3.76 (s, 3H), 3.67 (t, IH), 3.58 (m, 2H), 3.11 (m, 4H), 2.81 (m, 2H), 2.28 (m, IH), 1.79 (m, 2H), 1.69 (m, 2H), 1.58 (m, IH). MS (DCI/NH3) m/e 493 (M+H)+. Anal calcd for C26H28N4O4S-2HC1-0.5H2O: C, 54.36; H, 5.44; N, 9.75. Found: C, 54.25; H, 5.59; N, 9.68. Example 89 3-r3-(T±Vtrαn.γ-10-Methoxv-1.3.4.4a.5.10h-hexahvdro-2H-πi-henzopyranor3.4-clpyrido-3- vnpropvll-rilbenzthienor3.2-d1pvrimidine-2.4(lH.3HVdione hydrochloride Metiiyl 3-amino-benzo[b]thiophene-2-carboxylate (0.177 g, 0.72 mmol) and the product from Example 83E (0.165 g, 0.60 mmol) were treated as described in Example IF to yield the title compound (0.187 g, 61%): m.p. >300°C. *H NMR (300 MHz, DMSO) δ 12.65 (s, IH), 10.41 (br s, IH), 8.43 (d, IH), 8.13 (d, IH), 7.66 (t, IH), 7.57 (t, IH), 7.08 (t, IH), 6.54 (d, IH), 6.42 (d, IH), 4.14 (dd, IH), 4.02 (m, 2H), 3.76 (s, 3H), 3.63 (m, IH), 3.59 (m, 2H), 3.22-3.03 (m, 4H), 2.86 (m, IH), 2.77 (m, IH), 2.22 (m, IH), 2.13 (m, 2H), 1.54 (m, IH). MS (DCI/NH3) m/e 478 (M+H)+. Anal calcd for C26H27N3O4S- 1.0HC1: C, 60.75; H, 5.49; N, 8.17. Found: C, 60.48; H, 5.50; N, 8.02. Example 90 3-F2-((±Vtrαn.γ-10-Methoxy-1.3.4.4a.5.10h-hexahvdro-2H-ri1-henzopyranor3.4-clpyrido-3- yl)ethyll-fllbenzthienor3.2-dlpyrimidine-2.4(lH.3H)-dione hydrochloride Example 90A f± -trfln.γ-3-(Cyanomethyl)-10-Methoxy-1.3.4.4a.5.10b-hexahydro-2H-πi-henzopyranor3.4- clpyridme To a solution of the product from Example 83C (0.80 g, 3.65 mmol) and K2CO3 (1.21 g, 8.8 mmol) in acetone (20 mL) and water (2 mL) was added chloroacetonitrile (278 μL, 4.4 mmol), and the solution stirred at reflux for 18 hours. The reaction was cooled and poured into brine, the solution was extracted with 3x EtOAc, and the combined extracts were dried over MgSO4. The solvent was condensed in vacuo, and die crude product was chromatographed on Siθ2 using 30% EtOAc/hexanes to yield the title compound (0.55 g, 58%). l U NMR (300 MHz, DMSO) δ 7.04 (dd, IH), 6.50 (d, IH), 6.38 (d, IH), 4.08 (dd, IH), 3.74 (s, 3H), 3.68 (t, IH), 2.91 (m, 2H), 2.39 (ddt, 2H), 2.03 (m, IH), 1.83 (m, IH), 1.24 (m, IH). MS (DCI/NH3) m/e 259 (M+H)+. Example 90B (±.-trαn -3-(2-Aminoethvn-10-Methoxy-1.3.4.4a.5.10b-hexahydro-2H-πi-benzopyranor3.4- elpyridine To a solution of LiAlH4 (285 mg, 7.50 mmol) in Et2θ (25 mL) was added dropwise a solution of AICI3 (333 mg, 2.50 mmol) in Et2θ (10 mL), and the reaction was stirred for 10 min. A solution of the product from Example 90A (259 mg, 1.00 mmol) in THF (10 mL) was added via syringe, and the reaction stirred for 1 hour. The reaction was cooled to 0°C and quenched by the consecutive addition of water (2 mL), 1M NaOH (4 mL), and water (4 mL), and stirred for 1 hour. The mixture was filtered through a pad of Celite and rinsed widi EtOAc (100 mL) and CHCI3 (100 mL). The organic layer was rinsed with brine, dried over Na2SO4, and condensed in vacuo to yield the title compound (0.225 g, 86%). *H NMR (300 MHz, DMSO) δ 7.02 (dd, IH), 6.49 (d, IH), 6.38 (d, IH), 4.08 (dd, IH), 3.73 (s, 3H), 3.61 (t, IH), 2.93 (m, 2H), 2.89 (m, IH), 2.53 (m, 2H), 2.39 (m, IH), 2.33 (m, 2H), 2.07 (dt, IH), 1.79 (m, IH), 1.62 (m, 2H), 1.19 (m, IH). MS (DCI/NH3) m/e 263 (M+H)+. Example 90C 3-r2-((±Vtrα«.γ-10-Methoxy-1.3.4.4a.5.10h-hexahydro-2H-ril-henzopyranor3.4-c1pyrido-3- yl)ethyll-ri1benzthieno[3.2-dlpyrimidine-2.4(lH.3HVdione hydrochloride Methyl 3-amino-benzo[b]thiophene-2-carboxylate (0.158 g, 0.64 mmol) and die product from Example 90B (0.140 g, 0.53 mmol) were treated as described in Example IF to yield the title compound (0.143 g, 54%): m.p. >305°C. l U NMR (300 MHz, DMSO) δ 12.74 (s, IH), 10.34 (s, IH), 8.42 (d, IH), 8.12 (d, IH), 7.67 (dd, IH), 7.58 (dd, IH), 7.09 (dd, IH), 6.55 (d, IH), 6.43 (d, IH), 4.34 (m, 2H), 4.15 (dd, IH), 3.85 (m, 2H), 3.76 (s, 3H), 3.71 (t, IH), 3.42 (m, 2H), 3.15 (m, 2H), 2.98 (m, IH), 2.82 (m, IH), 2.20 (m, IH), 1.54 (m, IH). MS (DCI/NH3) m/e 464 (M+H)+. Anal calcd for C25H25N3O4S-HC1: C, 60.05; H, 5.24; N, 8.40. Found: C, 59.68; H, 5.21; N, 8.25. Example 91 7>- 2-((±)-trans- 10-Methoxy- 1.3.4.4a.5.10h-hexahydro-2H-. ll-henzopyranoB .4-clpyrido-3- yl.ethyll-6.7-dimethoxy-quinazoline-2.4(lH.3H_-dione hydrochloride Methyl 2-amino-4,5-dimethoxybenzoate (0.152 g, 0.64 mmol) and die product from Example 90B (0.140 g, 0.53 mmol) were treated as described in Example IF to yield the title compound (0.060 g, 22%): m.p. 291-2°C. H NMR (300 MHz, DMSO) δ 11.44 (s, IH), 10.09 (s, IH), 7.30 (s, IH), 7.09 (dd, IH), 6.72 (s, IH), 6.55 (d, IH), 6.42 (d, IH), 4.30 (m, 2H), 4.14 (dd, IH), 3.85 (m, 2H), 3.84 (s, 3H), 3.79 (s, 3H), 3.75 (s, 3H), 3.71 (t, IH), 3.42 (m, 2H), 3.15 (m, 2H), 2.95 (m, IH), 2.81 (m, IH), 2.16 (m, IH), 1.50 (m, IH). MS (DCI/NH3) m/e 468 (M+H)+. Anal, calcd for C24H29 3O6-1.25HC1: C, 58.52; H, 5.94; N, 8.19. Found: C, 58.79; H, 6.00; N, 8.01. Example 92 3-r3-((4aS.10bR -trα«.γ-10-Methoxy-1.3.4.4a.5.10h-hexahvdro-2H-riI-henzopyranof .4- c1pvrido-3-vl .propvll-pvridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione dihydrochloride Example 92A (4aS .1 ObRV tran.v- 10-Metiιoxy- 1.3 ,4.4a.5.10b-hexahvdro-2H- r 1 l-henzopyranoll ,4-clpyridine- 4-mentiιyl carbamate and (4aR.10hSVtrαn.v-10-Methoxy-1.3.4.4a.5.10h-hexahvdro-2H-πi- benzopyrano [3.4-cl pyridine-4-men thyl carbamate To a solution of the product from Example 83C (3.16 g, 14.41 mmol) and ethyldusopropylamine (5.02 mL, 28.8 mmol) in CH2CI2 (200 mL) was added at 0°C (+)- menthyl chloroformate (3.71 mL, 17.3 mmol). The reaction was warmed to 23°C and stirred for 3 hours. The reaction was then poured into 1M NaOH, the layers separated, and the aqueous layer extracted widi 3x E_2θ. The combined organic layers were dried over MgSO4, the solvent was condensed in vacuo, and the crude product was chromatographed on Siθ2 using 10% EtOAc/hexanes to yield a mixture of diastereomers (5.30 g, 92%). The 1:1 mixture of two diastereomers was separated on a preparatory chiral HLPC column. 1H NMR (300 MHz, DMSO) δ 7.04 (dd, IH), 6.50 (d, IH), 6.39 (d, IH), 4.46 (m, IH), 4.10 (m, 3H), 3.74 (s, 3H), 3.61 (t, IH), 2.94 (m, 2H), 2.63 (m, 2H), 1.89 (m, 2H), 1.83 (m, IH), 1.62 (m, 3H), 1.41 (m, IH), 1.36 (m, IH), 1.00 (m, 4H), 0.87 (m, 6H), 0.72 (m, 3H). MS (DCI/NH3) m/e 402 (M+H)+. Example 92B (4aS.10bR)-trα -10-Methoxy-1.3.4.4a.5.10b-hexahydro-2H-πi-benzopyranor3.4-clpyridine To a solution of (4aS, lObR), slower moving diastereomer from Example 92A (2.38 g, 5.93 mmol) in THF (125 mL) was added at 0°C a solution of 1.6M n-BuLi (15.0 mL, 24.0 mmol) dropwise, and the reaction was stirred for 15 min. The reaction was quenched with 1M NaOH, poured into brine, and extracted with 3x EtOAc and 2x CH2CI2. The combined extracts were dried over Na2SO4, d e solvent was condensed in vacuo, and the crude product was chromatographed on Siθ2 using NH3-saturated 5% MeOH/CH2θ2 to yield the title compound (1.07 g, 82%); !H NMR (300 MHz, DMSO) δ 7.02 (dd, IH), 6.48 (d, IH), 6.36 (d, IH), 4.03 (dd, IH), 3.72 (s, 3H), 3.55 (dd, IH), 3.01 (m, IH), 2.94 (dd, IH), 2.83 (ddd, IH), 2.62 (dt, IH), 2.51 (dt, IH), 2.29 (t, IH), 1.64 (ddt, IH), 1.05 (ddd, IH). MS (DCI/NH3) m/e 220 (M+H)+ Example 92C (4aS.10bRVtrαn.γ-3-f3-Aminopropyn-10-Methoxy-1.3.4.4a.5.10h-hexahvdro-2H-ni- benzopyrano l " 3 ,4-cl pyridine The product from Example 92B was treated as described in Examples 83 D and 83E to yield the title compound; *H NMR (300 MHz, DMSO) δ 7.02 (dd, IH), 6.48 (d, IH), 6.37 (d, IH), 4.08 (dd, IH), 3.73 (s, 3H), 3.62 (t, IH), 2.96 (m, 2H), 2.89 (m, IH), 2.57 (m, 2H), 2.39 (m, IH), 2.33 (m, 2H), 2.01 (dt, IH), 1.77 (m, IH), 1.66 (t, IH), 1.51 (m, 2H), 1.17 (m, IH). MS (DCI/NH3) m/e 277 (M+H)+. Example 92D 3-r3-((4aS.10hRVtrαn.γ-10-Methoxy-1.3.4.4a.5.10h-hexahvdro-2H-rn-henzopyranor3.4- c1pyrido-3-yl)propyll-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4riH.3H)-dione dihydrochloride Methyl 3-amino-thieno[3,2-b]pyridine-2-carboxylate (107 mg, 0.456 mmol) and the product from Example 92C (105 mg, 0.380 mmol) were treated as described in Example IF to yield the title compound (135 mg, 64%): m.p. 235°C; l U NMR (300 MHz, DMSO) δ 12.72 (s, IH), 10.66 (br s, IH), 8.86 (d, IH), 8.68 (d, IH), 7.68 (dd, IH), 7.09 (t, IH), 6.53 (d, IH), 6.41 (d, IH), 4.14 (dd, IH), 4.00 (m, 2H), 3.76 (s, 3H), 3.63 (m, IH), 3.59 (m, 2H), 3.21-3.03 (m, 4H), 2.86 (m, IH), 2.76 (m, IH), 2.28 (m, IH), 2.12 (m, 2H), 1.56 (m, IH). MS (DCI/NH3) m/e 479 (M+H)+.Anal calcd for C25H26N4O4S-2.OHCl-O.5H2O: C, 53.57; H, 5.22; N, 10.00. Found: C, 53.35; H, 5.05; N, 9.92. [α]D 25 -°° C = -79.4°. Example 93 3-r3-((4aR.10hSV_r.7/ γ-10-Methoxy-1.3.4.4a.5.10h-hexahvdro-2H-rn-henzopyranor3.4- clpyrido-3-v1.ρropyll-Dyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4πH.3HVdione dihydrochloride Example 93A (4aR.10bS)-trα^-10-Methoxy-1.3.4.4a.5.10h-hexahvdro-2H-rn-benzopyranor3.4-clpyridine To a solution of (4aR, lObS), faster moving diastereomer from Example 92A (2.27 g, 5.74 mmol) in THF (125 mL) was added at 0°C a solution of 1.6M n-BuLi (15.0 mL, 24.0 mmol) dropwise, and the reaction was stirred for 15 min. The reaction was quenched widi 1M NaOH, poured into brine, and extracted with 3x EtOAc and 2x CH2CI2. The combined extracts were dried over Na2SO4, d e solvent was condensed in vacuo, and the crude product was chromatographed on Siθ2 using NH3-saturated 5% MeOH/CH2θ2 to yield the title compound (0.96 g, 80%); l U NMR (300 MHz, DMSO) δ 7.02 (dd, IH), 6.48 (d, IH), 6.36 (d, IH), 4.03 (dd, IH), 3.72 (s, 3H), 3.55 (dd, IH), 3.01 (m, IH), 2.94 (dd, IH), 2.83 (ddd, IH), 2.62 (dt, IH), 2.51 (dt, IH), 2.29 (t, IH), 1.64 (ddt, IH), 1.05 (ddd, IH). MS (DCI/NH3) m/e 220 (M+H)+ Example 93B r4aR.10bSVtrαn.γ-3-(3-AminopropylV10-Methoxy-1.3.4.4a.5.10h-hexahvdro-2H-ril- henzoρyranoI3.4-clpyridine The product from Example 93A was treated as described in Examples 83D and 83E to yield the title compound; l U NMR (300 MHz, DMSO) δ 7.02 (dd, IH), 6.48 (d, IH), 6.37 (d, IH), 4.08 (dd, IH), 3.73 (s, 3H), 3.62 (t, IH), 2.96 (m, 2H), 2.89 (m, IH), 2.57 (m, 2H), 2.39 (m, IH), 2.33 (m, 2H), 2.01 (dt, IH), 1.77 (m, IH), 1.66 (t, IH), 1.51 (m, 2H), 1.17 (m, IH). MS (DCI/NH3) m/e 277 (M+H)+. Example 93C 3-r3-((4aR.10hSVtrα».γ-10-Methoxy-1.3.4.4a.5.10b-hexahvdro-2H-ril-henzopyranor3.4- c1pyrido-3-yl)propyl]-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione dihydrochloride Methyl 3-amino-thieno[3,2-b]pyridine-2-carboxylate (0.116 g, 0.495 mmol) and die product from Example 93B (0.114 g, 0.413 mmol) were treated as described in Example IF to yield the title compound (0.091 g, 39%): m.p. 235°C. l U NMR (300 MHz, DMSO) δ 12.72 (s, IH), 10.66 (br s, IH), 8.86 (d, IH), 8.68 (d, IH), 7.68 (dd, IH), 7.09 (t, IH), 6.53 (d, IH), 6.41 (d, IH), 4.14 (dd, IH), 4.00 (m, 2H), 3.76 (s, 3H), 3.63 (m, IH), 3.59 (m, 2H), 3.21-3.03 (m, 4H), 2.86 (m, IH), 2.76 (m, IH), 2.28 (m, IH), 2.12 (m, 2H), 1.56 (m, IH). MS (DCI/NH3) m/e 479 (M+H)+. Anal calcd for C25H26N4O4S-2.0HC1-H2O: C, 52.73; H, 5.31; N, 9.84. Found: C, 52.59; H, 5.04; N, 9.75. [αjD 25 - 0 ° C = +77.7°. Example 94 3-r4- (( 4aR.10hSVtrfln.γ-10-Methoxy-1.3.4.4a.5.10h-hexahvdro-2H-πi-henzopyranor3.4- clDyrido-3-yl)butyll-Dyridor2'.3':4.51thienor3.2-d1nyrimidine-2.4π H.3HVdion_. dihydrochloride Example 94A r4aR.10hS .-tran.γ-3-(4-Aminohutyl)-10-Methoxy-1.3.4.4a.5.10h-hexahvdro-2H-m- benzopyranor3.4-clpyridine The product from Example 93A was treated as described in Examples 85 A and 85B to yield the title compound; l U NMR (300 MHz, DMSO) δ 7.02 (dd, IH), 6.48 (d, IH), 6.37 (d, IH), 4.08 (dd, IH), 3.73 (s, 3H), 3.62 (t, IH), 2.97 ( , 2H), 2.89 (m, IH), 2.53 (m, 2H), 2.38 (m, IH), 2.29 (m, 2H), 2.01 (dt, IH), 1.78 (m, IH), 1.67 (t, IH), 1.46 (m, 2H), 1.34 (m, 2H), 1.18 (m, IH). MS (DCI/NH3) m/e 291 (M+H)+. Example 94B 3-r4-((4aR.10hSVtrαn.γ-10-Methoxy-1.3.4.4a.5.10b-hexahydro-2H-ril-henzopyranor3.4- c1pyrido-3-yl.hutyll-pyrido 2'.3':4.51thienor3.2-d1pyrimidine-2.4(lH.3H)-dione dihydrochloride Methyl 3-amino-thieno[3,2-b]pyridine-2-carboxylate (0.087 g, 0.372 mmol) and die product from Example 94A (0.090 g, 0.310 mmol) were treated as described in Example IF to yield the title compound (0.080 g, 43%): *H NMR (300 MHz, DMSO) δ 12.68 (s, IH), 10.65 (br s, IH), 8.85 (d, IH), 8.66 (d, IH), 7.68 (dd, IH), 7.09 (t, IH), 6.54 (d, IH), 6.42 (d, IH), 4.17 (dd, IH), 3.97 (t, 2H), 3.76 (s, 3H), 3.67 (t, IH), 3.58 (m, 2H), 3.11 (m, 4H), 2.81 (m, 2H), 2.28 (m, IH), 1.79 (m, 2H), 1.69 (m, 2H), 1.58 (m, IH). MS (DCI/NH3) m/e 493 (M+H)+. Anal calcd for C26H28N4O4S-2.OHCl-2.OH2O: C, 51.92; H, 5.70; N, 9.31. Found: C, 52.27; H, 5.56; N, 9.24. [α]D 25 -°° C = +83.2°. Example 95 3-r4-((4aS. IQbRVtrans- 10-Methoxy- 1.3.4.4a.5.1 h-hexahvdro-2H-r ll-benzopyranor3.4- clpyrido-3-yl.butyll-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H -dione dihydrochloride Example 95A (4aS.10bR)-trαn^-3-(4-Aminobutyl)-10-Methoxy-1.3.4.4a.5.10b-hexahvdro-2H-rn- henzopvranor3.4-clpvridine The product from Example 92B was treated as described in Examples 85A and 85B to yield the title compound; l U NMR (300 MHz, DMSO) δ 7.02 (dd, IH), 6.48 (d, IH), 6.37 (d, IH), 4.08 (dd, IH), 3.73 (s, 3H), 3.62 (t, IH), 2.97 (m, 2H), 2.89 (m, IH), 2.53 (m, 2H), 2.38 (m, IH), 2.29 (m, 2H), 2.01 (dt, IH), 1.78 (m, IH), 1.67 (t, IH), 1.46 (m, 2H), 1.34 (m, 2H), 1.18 (m, IH). MS (DCI/NH3) m/e 291 (M+H)+. Example 95B 3-r4-((4aS.10hRVtrfl».γ-10-Methoxy-1.3.4.4a.5.10b-hexahydro-2H-ri1-henzopyranor3.4- c1pyrido-3-yl.hutyll-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H)-dione dihydrochloride Methyl 3-amino-thieno[3,2-b]pyridine-2-carboxylate (0.097 g, 0.413 mmol) and die product from Example 95 A (0.100 g, 0.344 mmol) were treated as described in Example IF to yield the title compound (0.114 g, 55%): *H NMR (300 MHz, DMSO) δ 12.68 (s, IH), 10.65 (br s, IH), 8.85 (d, IH), 8.66 (d, IH), 7.68 (dd, IH), 7.09 (t, 1H), 6.54 (d, IH), 6.42 (d, IH), 4.17 (dd, 1H), 3.97 (t, 2H), 3.76 (s, 3H), 3.67 (t, IH), 3.58 (m, 2H), 3.11 (m, 4H), 2.81 (m, 2H), 2.28 (m, IH), 1.79 (m, 2H), 1.69 (m, 2H), 1.58 (m, IH). MS (DCI/NH3) m/e 493 (M+H)+. Anal calcd for C26H28N4O4S-2.OHCl-2.OH2O: C, 51.92; H, 5.70; N, 9.31. Found: C, 51.48; H, 5.62; N, 9.05. [α]D 25 -°° C = -82.4°. Example 96 3-r4-((4aR.10bSVtrαn.γ-10-Methoxy-1.3.4.4a.5.10b-hexahvdro-2H-ril-henzopyranor3.4- c1pyrido-3-yl)butyll-8-chloro-pyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione dihydrochloride The product from Example 10C (0.106 g, 0.372 mmol) and the product from Example 94A (0.090 g, 0.310 mmol) were treated as described in Example IF to yield the title compound (0.020 g, 11%): m.p. 253-4°C. *H NMR (300 MHz, DMSO) δ 12.92 (s, IH), 10.45 (br s, IH), 9.02 (s, IH), 7.09 (t, IH), 6.54 (d, IH), 6.42 (d, IH), 4.17 (dd, IH), 3.97 (t, 2H), 3.76 (s, 3H), 3.67 (t, IH), 3.57 (m, 2H), 3.11 (m, 4H), 2.81 (m, 2H), 2.25 (m, IH), 1.78 (m, 2H), 1.69 (m, 2H), 1.56 (m, IH). MS (DCI/NH3) m/e 528 (M+H)+. Anal calcd for C25H26N5O4SCl-2.OHCl-O.5H2O: C, 49.23; H, 4.79; N, 11.48. Found: C, 48.95; H, 4.77; N, 11.22. [α]D 25 0 ° C = +57.6°. Example 97 3-r4-r(4aS.10hRVtrfln.γ-10-Methoxy-1.3.4.4a.5.10h-hexahvdro-2H-πi-henzopyranor3.4- clpvrido-3-vl .hutvll-8-chloro-pvra7.inor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione dihydrQchlQride The product from Example IOC (0.189 g, 0.667 mmol) and the product from Example 95 A (0.176 g, 0.606 mmol) were treated as described in Example IF to yield the title compound (0.192 g, 55%): m.p. 254-5°C. H NMR (300 MHz, DMSO) δ 12.92 (s, IH), 10.45 (br s, IH), 9.02 (s, IH), 7.09 (t, IH), 6.54 (d, IH), 6.42 (d, IH), 4.17 (dd, IH), 3.97 (t, 2H), 3.76 (s, 3H), 3.67 (t, IH), 3.57 (m, 2H), 3.11 (m, 4H), 2.81 (m, 2H), 2.25 (m, IH), 1.78 (m, 2H), 1.69 (m, 2H), 1.56 (m, IH). MS (DCI/NH3) m/e 528 (M+H)+. Anal calcd for C25H26N4O4S-2.OHCl-3.OH2O: C, 45.84; H, 5.23; N, 10.69. Found: C, 45.47; H, 5.03; N, 10.51. [α]D 25 -°° C = -58.4°. Example 98 3-r4-f(4aS.10bRVtr_ι».γ-10-Methoxy-1.3.4.4a.5.10h-hexahvdro-2H-ril-henzopyranor3.4- clpyrido-3-ynbutyn-8-methoxy-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione hydrochloride The product from Example 7 A (0.24 g, 1.00 mmol) and the product from Example 95A (0.276 g, 1.00 mmol) were treated as described in Example IF to yield the title compound (0.30 g, 57%): m.p. >250°; H NMR (300 MHz, CDCl3(free base)) δ 8.04 (d, IH), 7.03 (t, IH), 6.98 (d, IH), 6.46 (d, IH), 6.41 (d, IH), 4.12 ( t, 2H), 4.08 (dd, IH), 4.04 (s, 3H), 3.79 (s, 3H), 3.67 (m, IH), 3.08 (m, IH), 2.98 (m, 2H), 2.42 (m, 3H), 2.13 (m, IH), 2.02 (m, IH), 1.76 (m, 3H), 1.62 (m, 2H), 1.38 (m, IH); MS (DCI/NH3) m/e 523(M+H)+; Analysis calc'd for C27H30N4O5S-HC1-0.5H2O: C, 57.09; H, 5.68; N, 9.86; found: C, 57.01; H, 5.43; N, 9.64. Example 99 3-r4-((4aS.10bRVtrαn.γ-10-Methoxy-1.3.4.4a.5.10b-hexahvdro-2H-I11-henzopyranor3.4- c1pyrido-3-yl)butyl1-8-methoxy-pyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4('lH.3HVdionp. hydrochloride The product from Example 31A (0.167 g, 0.70 mmol) and the product from Example 95 A (0.195 g, 0.70 mmol) were treated as described in Example IF to yield the title compound (0.29 g, 78%): m.p. 220-224°; l U NMR (300 MHz, CDCl3(free base)) δ 8.39 (s, IH), 7.04 (t, IH), 6.46 (d, IH), 6.41 (d, IH), 4.11 (m, 3H), 4.08 (s, 3H), 3.79 (s, 3H), 3.67 (t, IH), 3.08 (m, IH), 2.98 (m, 2H), 2.42 (m, 3H), 2.15 (m, IH), 2.0 (m, IH), 1.78 (m, 3H), 1.6 (m, 2H), 1.4 (m, IH); MS (DCI/NH3) m/e 524(M+H)+; Analysis calc'd for C26H29N5O5S-HC1-2H2O: C, 52.39; H, 5.75; N, 11.75; found: C, 52.59; H, 5.70; N, 1 1.65. Example 100 3-r4-((4aS.10bR_-trαn.γ-10-Methoxy-1.3.4.4a.5.10b-hexahydro-2H-ril-benzopyranor3.4- clpyrido-3-yl.butyn-8-phenyl-pyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3m-dione hydrochloride The product from Example 9B (0.16 g, 0.56 mmol) and the product from Example 95 A (0.154 g, 0.56 mmol) were treated as described in Example IF to yield the titie compound (0.17 g, 53%): m.p. >250°; H NMR (300 MHz, CDCl3(free base)) δ 9.16 (s, IH), 8.08 (m, 2H), 7.59 (m, 3H), 7.02 (t, IH), 6.42 (d, IH), 6.38 (d, IH), 4.18 (m, 2H), 3.93 (dd, IH), 3.77 (s, 3H), 3.6 (t, IH), 3.18 (m, IH), 3.07 (m, IH), 2.93 (m, IH), 2.5 (m, 2H), 2.41 (m, IH), 2.16 (m, IH), 1.97 (m, IH), 1.8 (m, 3H), 1.76 (m, 2H), 1.18 (m, IH); MS (DCI/NH3) m/e 570(M+H)+; Analysis calc'd for C3χH3iN5Sθ4-HCM.5H2θ: C, 58.81; H, 5.57; N, 11.06; found: C, 58.69; H, 5.52; N, 11.03. Example 101 3-r4-((4aS.10bRVtrαn.γ-10-Methoxy-1.3.4.4a.5.10b-hexahvdro-2H-ni-benzopyranor3.4- clpyrido-3-yDbutyll-8-phenyl-pyridor2'.3':4.51thienor3.2-dlpyrimidine-2.4πH.3HVdione dihydrochloride The product from Example 95B (0.145 g, 0.50 mmol) and the product from Example 52A (0.15 g, 0.53 mmol) were treated as described in Example IF to yield 0.230 g (80%) of the title compound: m.p. > 255°; l U NMR (300 MHz, CDCI3 (free base)) δ 1.35 (dd, J=3, 12 Hz, IH), 1.58-1.72 (m, 2H), 1.72-1.87 (m, 3H), 1.91-2.05 (m, IH), 2.12 (dd, J=3, 12 Hz, IH), 2.36-2.50 (m, 3H), 2.89-3.02 (m, 2H), 3-04-3.13 (m, IH), 3.63 (dd, J=10, 11 Hz, IH), 3.77 (s, 3H), 4.03 (dd, J=3, 10 Hz, IH), 4.18 (t, J=7 Hz, 2H), 6.39 (dd, J=l, 8 Hz, IH), 6.45 (dd, J=l, 8 Hz, IH), 7.03 (t, J=8 Hz, IH), 7.45-7.56 (m, 3H), 7.93 (d, J=9 Hz, IH), 8.05-8.11 (m, 2H), 8.27 (d, J=9 Hz, IH); MS (CI(NH3)) m/e (M+H)+ at 569; Analysis calc'd for C32H32N4θ4S « (HCl)2'(H2O)o.5: C, 59.07; H, 5.42; N, 8.61; found: C, 59.04; H, 5.53; N, 8.35. Example 102 3-r4-r(4aS.10bRVtrαn.γ-10-Methoxy-1.3.4.4a.5.10b-hexahvdro-2H-πi-benzopyranor3.4- clpvrido-3-vnhutvl]-7-chloro-pvridor3'.2':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione hydrochloride The product from Example 95B (0.290 g, 1.0 mmol) and methyl 3-amino-6-chloro- thieno[2,3-b]pyridine-2-carboxylate (0.242 g, 1.00 mmol) were treated as described in Example IF to yield 0.375 g (66%) of the title compound.: m.p. 236° (d); l U NMR (300 MHz, DMSO- d6) δ 1.4-1.6 (m, 2H), 1.6-1.85 (n, 4H), 2.04-2.24 (m, 2H), 2.7-3.6 (m, 6H), 3.66 (t, 2H), 3.77 (s, 3H), 3.95 (t, 2H), 4.15 (m, IH), 6.41 (d, IH), 6.52 (d, IH), 7.07 (t, IH), 7.78 (d, IH), 8.77 (d, IH); MS (DCI/NH3) m/e 527 (529 (M+H)+); Analysis calc'd for C26H28C12 4O4S-1.25H2O: C, 53.29; H, 5.25; N, 9.56; Cl, 12.10; found: C, 53.26; H, 5.28; N, 9.27; Cl, 1 1.82. Example 103 3-r4-( 4aS.10bRVfrα».γ-10-Methoxy-1.3.4.4a.5.10b-hexahvdro-2H-πi-benzopyranor3.4- clpyrido-3-vnhutyη-7-methoxy-pyridor3'.2':4.51thienor3.2-dlpyrimidine-2.4(lH.3HVdione hydrochloride The product from Example 95B (0.290 g, 1.0 mmol) and methyl 3-amino-6-methoxy- thieno[2,3-b]pyridine-2-carboxylate (0.238 g, 1.00 mmol) were treated as described in Example IF to yield 0.315 g (56%) of the title compound.: m.p. 224° (d); 1H NMR (300 MHz, DMSO- d ) δ 1.4-1.6 (m, 2H), 1.6-1.85 (m, 4H), 2.04-2.15 (m, 2H), 2.7-3.6 (m, 6H), 3.67 (t, 2H), 3.77 (s, 3H), 3.96 (m, 2H), 3.98 (s, 3H), 4.15 (m, IH), 6.41 (d, IH), 6.54 (d, IH), 7.07 (d, IH), 7.08 (t, IH), 8.58 (d, IH); MS (DCI/NH3) m/e 523 (M+H)+; Analysis calc'd for C27H31CIN4O5S I.4H2O: C, 54.65; H, 5.78; N, 9.44; Cl, 7.47; found: C, 54.52; H, 5.91; N, 9.31; Cl, 7.55. Example 104 3-r4-(-d.γ-7-Hvdroxy-9-methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4-c]pyrrol-2- vnhutyll-8-phenvI-pyrazinor2'.3':4.51thienor3.2-d1pvrimidine-2.4('lH.3m-dione Example I04A 3-r4-( ' -d.γ-7-Hvdroxy-9-methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4-clpyrrole A solution of 7-hydroxy-5-methoxycoumarin (300 mg, 1.6 mmol), prepared as described in Monatsh. Chem,, 1333, (1988), in dry DMF (10 mL) was treated with a 60 % dispersion of sodium hydride (70 mg, 1.7 mmol), stirred for 1 hour, treated with benzyl bromide (0.37 mL, 3.1 mmol) and stirred for 1 hour. The mixture was diluted with diethyl ether (100 mL), washed with water, washed with brine, dried (MgSO4), filtered and concentrated. Purification of the residue on sitica gel using dichloromethane and tiien 25: 1 dichloromethane:ethyl acetate provided 420 mg (95 %) of the intermediate benzylated derivative. A solution of 7-benzyloxy-5-methoxycoumarin (0.42 g, 1.5 mmol) in dichloromethane (5 mL) at 0°C was treated with trifluoracetic acid (0.15 mL of a I M solution in dichloromethane), treated dropwise with a solution of N-methoxymethyl-N- trimethylsUylmethylbenzylamine, (750 mg, 3.0 mmol) in dichloromethane (5 mL) and stirred for 1 hour at ambient temperature. The mixture was diluted with dichloromethane, washed with sodium bicarbonate solution, dried (MgSO4), filterd and concentrated. The residue was dissolved in THF (5 mL), added dropwise to a stirred suspension of lithium aluminum hydride (115 mg, 3.0 mmol) in THF (10 mL), stirred for 1 hour and treated with sodium sulfate decahydrate (5 g) in portions. The mixture was diluted with ethyl acetate, filtered and concentrated. Purification on sUica gel using 2: 1 ethyl acetate exane provided 620 mg (96 %) of die intermediate diol. A solution of the diol (0.60 g, 1.4 mmol) in a mixture of acetonitrile (16 mL) and carbon tetrachloride (4 mL) was treated with triphenylphosphine (0.73 g, 2.8 mmol), heated to reflux for 10 minutes, cooled to ambient temperature and concentrated. Purification on stiica gel using 2:1 diethyl etheπhexane saturated widi ammonia provided 530 mg (92 %) of the intermediate chloro-phenol. The chloro-phenol (530 mg, 1.3 mmol) was dissolved in THF (30 mL). treated with potassium tert-butoxide (3 mL of a 1 M in THF solution), stirred for 1 hour, concentrated, treated with dichloromethane (100 mL), washed with water (25 mL), dried (MgSO4), filtered and concentrated to yield 0.40 g (76 %) of the cyclized product. A suspension of the this product (0.40 g, 0.96 mmol) and 10 % palladium on carbon (0.070 g) in methanol (20 mL) was stirred under a hydrogen atmosphere for 16 hours. The atmosphere was exchanged witii nitrogen, the paUadium on carbon was removed by filtratioin and die mixture was concentrated. Purification of the residue on siUca gel using 8:1:1 ethyl acetate:water:formic acid provided an impure product which was repurified on silica gel using 40 % ethanol in dichloromethane saturated with ammonia providing 0.060 g (28 %) of the title compound: 1H NMR (300 MHz, DMSO-d6) d 2.25-2.39 (m, IH), 2.34 (dd, IH), 2.48-2.55 (m, IH), 2.89 (q, IH), 3.10 (dd, IH), 3.33-3.42 (m, IH), 3.49 (t, IH), 3.70 (s, 3H), 3.98 (dd, IH), 5.86 (d, J=l Hz, 2H), 5.99 (d, J=l Hz, 2H), 9.23 (bs, IH); MS (DCI/NH3) m/e 222 (M+NH4)+. Example 104B 3-r4-(-c/..-7-Hvdroxy-9-methoxy-1.2.3.3a.4.9h-hexahydro-ril-benzopyranor3.4-clpyrrol-2- yl ) butyll-8-phenyl-pyrazino[2'.3':4.51thienor3.2-d1pyrimidine-2.4(lH.3H)-dione A solution of the product from Example 104A (60 mg, 0.27 mmol) in DMF (1.5 mL) was treated with 4-bromobutyronitrile (0.030 mL, 0.30 mmol) and sodium bicarbonate (25 mg, 0.30 mmol), heated for 3 hours at 70°C and concentrated. Purification using silica gel with 2 % ethanol in dichloromethane saturated witii ammonia provided 70 mg (90 %) of the intermediate nitrile. A suspension of lithium aluminum hydride (70 mg, 1.8 mmol) in a mixture of diethyl ether (3 mL) and THF (3 mL) was treated with aluminum chloride (81 mg, 0.61 mmol) in diethyl ether (3 mL), stirred for 1 hour, treated witii the nitrile (70 mg, 0.24 mmol), stirred for 2 hours, treated with water (0.080 mL), treated with 4 M sodium hydroxide (0.080 mL), treated witii water (0.24 mL), stirred for 15 minutes and concentrated. Purification of the residue using sUica gel with 12:5:3 ethyl acetate:formic acid:water provided die formic acid salt of die primary amine product. A solution of the product from Example 9B (82 mg, 0.29 mmol) in THF (5 mL) was treated with sodium bicarbonate (100 mg, 1.2 mmol), treated with phosgene (3.75 mL of a 1.93 M solution in toluene), stirred for 1 hour, concentrated, dried at 60°C under high vacuum for 1 hour and cooled to ambient temperature. The residue was treated with a suspension of the primary amine intermediate in DMF (4.5 mL), stirred for 1 hour, heated to 150°C under nitrogen for 30 minutes and concentrated. Purification of the residue using silica gel with 10 % and then 20 % ethanol in dichloromethane saturated with ammonia provided 60 mg (43 %) of the title compound: 1H NMR (300 MHz, DMSO-d6) d 1.42-1.54 (m, 2H), 1.58-1.71 (m, 2H), 2.14-2.25 (m, 2H), 2.38-2.51 (m, 2H), 2.99 (t, IH), 3.10 (q, IH), 3.17-3.26 (m, IH), 3.39-3.49 (m, IH), 3.62 (t, IH), 3.69 (s, 3H), 3.90-4.00 (m, 3H), 5.84 (d, J=l Hz, 2H), 5.98 (d, J=l Hz, 2H), 7.53-7.65 (m, 3H), 8.40-8.47 (m, 2H), 9.24 (bs, IH), 9.51 (s, IH), 12.60 (bs, IH); MS (ESI) m/e 572 (M+H)+;570 (M-H)". Example 105 3-[4-f(3aR.9bR)-d^-6-Hydroxy-9-methoxy-1.2.3.3a.4.9h-hexahvdro-πi-henzopyranol3.4- c1pyrrol-2-vnhutvll-8-phenvl-pvrazinor2'.3':4.51thienor3.2-dlpvrimidine-2.4riH.3HVdione Example 105 A (3aR.9bRVcis 6-Bromo-9-methoxv-1.2.3.3a.4.9h-hexahvdro-ni-henzopyranor3.4-clpyrrole The HCl salt of the product from Example 1C (1 g, 4.14 mmol) was dissolved in formic acid, cooled to 0°and Br2 ( 0.68 g, 4.25 mmol) was added . The reaction was stirred at 0°C for lhr then solvent was evaporated and the product was partitioned in IN NaOH/CH2θ2.The organic extracts were dried and concentrated . The resulting product was purified by column chromatography on siUca gel, eluting with 5% EtOH / CH2CI2 sat.withNH4.OH to yield 0.45 g (38%) of the title compound. !H NMR (300 MHz, CDCI3) d 2.58 (m, IH), 2.64 (m, IH), 2.84 (dd, IH), 3.24 (q, IH), 3.32 (dd, IH), 3.62 (dd.lH), 3.80 (m, IH), 3.81 (s, 3H), 6.38 (d, IH), 7.32 (d, IH); MS (DCI(NH3» m/e 284 (M+H)+ Example 105B (3aR.9hR)-cis 6-Hydroxy -9-methoxy-1.2.3.3a.4.9b-hexahvdro-rn- henzopyrano.3.4-clpyπ-ole The product from Example 105A (0.45 g, 1.6 mmol) was dissolved in CH2CI2 and di- t-butyl-dicarbonate (0.69 g, 3.2 mmol) was added. After the reaction mixture was stirred at rt for lhr it was evaporated and the residue was purified by column chromatography on sUica gel, eluting with 1: 1 hexane : EtOAc to yield t-BOC-protected product (0.42 g ) To the solution of t- BOC-protected product (0.18 g, 0.46 mmol) in THF and cooled to -78°C was added 0.22 ml of 2.5M n-BuLi solution in hexane. The reaction mixture was stirred at -78°C for lhr and triisopropyl borate (0.11 g, 0.59 mmol) was added. The reaction mixture was warmed to rt and stirred for 2 hr. Then acetic acid (0.55 mmol) was added to the reaction mixture followed by the addition of H2O2 (0.78 mmol). The reaction mixture was stirred at rt for 16 hr, then quenched into NH4CI solution and extracted with CH2CI2. The organic layer was dried over MgSO4 and concentrated to yield t-BOC protected titie compound (0.8 g). To the solution of t-BOC- protected titie compound (0.12 g, 0.37 mmol) in CH2C12 was added CF3COOH and the rection mixture was stirred overnight. Solvent was evaporated and residue was purified by column chromatography eluting with 2% EtOH/CH2Cl to yield 0.08 g of the titie compound. 1H NMR (300 MHz, CDCI3) d 2.67 (m, 1H),2.82 (dd, IH), 2.97 (dd, IH), 3.39 (m, 2H), 3.62 (dd,lH), 3.78 (m, IH), 3.77 (s, 3H), 3.81 (m, IH), 4.18 (dd, IH), 6.37 (d, IH), 6.74 (d, IH); Example 105C GaR.9hRVcis-2-(3-cvanopropyl - 6-Hvdroxy -9-methoxy-L2.3.3a.4.9h-hexahvdro-πi- benzQpyrar.or3_4-c,pyrrole To the product of Example 105B (0.075 g, 0.34 mmol) in DMF (2 ml) was added NaHCO3 (0.032 g, 0.38 mmol) and 4-bromobutyronitrile (0.056 g, 0.38 mmol). The reaction mixture was heated at 90°C for 3 hr and evaporated. The residue was purified by column chromatography on sUica gel, eluting with 2%EtOH/CH2θ2/ sat. widi ammonia to yield 0.086 g(88 %) of the title compound. l U NMR (300 MHz, CDCI3) d 1.82 (m, 2H), 2.26 (m, 2H), 2.43 (t, 2H), 2.6 (m, 3H), 3.39 (m, 2H), 3.75 (s, 3H), 3.87 (m, IH), 4.12 (dd, IH), 5.15 (d, IH), 6.73 (d, IH) Example 105D ( 3aR.9bRVcis-2- ( 4-aminohutvn- 6-Hydroxy -9-methoxy-1.2.3.3a.4.9b-hexahydro-ril- benzopyrano [3 ,4-clpyrrole The product of Example 105C (0.084 g, 0.3 mmol) in THF was added to the solution of LiAlH4 (0.085 g, 2.3 mmol) in THF and AICI3 (0.1 g, 0.75 mmol) in ether. The reaction mixture was stirred at rt for 3hr to yield after Fieser workup 0.075 g (88%) of the title compound. *H NMR (300 MHz, CDCI3) dl.48-1.7 (m, 4H), 2,38 (m, IH), 2.43 (m, 3H), 2.73 (m, 2H), 3.06 ( m, IH), 3.39 (m, 2H), 3.47 (m, IH), 3.77 (s, 3H), 3.84 -33.95 (m, 2H), 4.05 (m, IH), 6.38 (d, IH), 6.73 (d, IH). Example 105E 3-r4-((3aR.9bR)-cis-6-Hydroxy 9-methoxy-1.2.3.3a4.9b-hexahydro-[ll-benzopyrano[3.4- c1pyrrol-2-yl)butyll-8-phenyl-pyrazinor2'.3':4.51thieno 3.2-dlpyrimidine-2.4(lH.3H)-dione The product from the Example 105D (0.084 g,0.3mmol) and the product from the Example 9B (0.087 g, 0.3 mmol) were treated as described in die Example IF to 0.03g (17%) of the title compound. *H NMR (500 MHz, CDCI3) d 1.72 (m, 2H), 1.81 (m, IH), 2.45 (m, IH), 2.57 (m, IH), 2.73 (m, 3H), 3.32 (m, IH), 3.5 (m, IH) 3.7 (s, 3H), 3.86 (m, IH), 4.06 (m, IH), 4.15 (m, 2H), 6.28 (d, IH), 6.67 (d, IH), 7.55 (m, 3H), 8.08 (m, 2H), 9.12 (s, IH); MS(ESI)m/e 572(M+H) +S Example 106 3-r4-f(3aR.9bR)-c/.γ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-henzopyranor3.4-c1pyrrol-2- yl .hutyl1-8-(2-hvdroxyphenyl)-pyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4dH.3H.-dione To the solution of the product from Example 16 (0.075 g, 0.136 mmol) in DMF (2ml) was added Pd(dppf)Cl2 (0.03 g, 0.034 mmol), 2-(benzyloxy)benzeneboronic acid (0.033 g, 0.145 mmol) and triethylamine (0.05ml). The reaction mixture was heated at 90°C for 3 hours. Then it was diluted with water and the precipitate formed was filtered off. The filtrate was extracted with EtOAc, dried over MgSO4 and evaporated. The residue was chromatographed on silica gel, eluting with 5% ethanol/CH2Cl2 saturated with ammonia to yield 0.05 g (55%) of oil. To the solution of this product (0.08 g, 0.12 mmol) in CH3OH (2ml) was added ammonium formate (0.07 g) and Pd/C (0.07 g). The reaction mixture was refluxed for 2 hours, then it was filtered and the evaporated residue was chromatographed on sUicagel eluting with 10% EtOH/CH2Cl2/sat. with NH4OH to yield 0.022g (32%) of title compound:^ NMR (300 MHz, CDCI3) d 1.8 (m, 4H), 2.5 (m, IH), 2.58 (m, IH), 2.8 (m, 3H), 3.58 (m, 2H), 3.78 (s, 3H), 3.82 (m, 2H), 3.88 (dd, IH), 4.28 (m, 2H), 6.45 (m, 2H), 7.06 (m, 3H), 7.42 (t, IH), 7.92 (dd, 1H),9.33 (s, IH); MS(ESI)m/e 572 (M+H)+ Example 107 3-r4-((3aR.9bR)-d.γ-9-Methoxy-1.2.3.3a.4.9h-hexahvdro-ril-benzopyranor3.4-c1pyrrol-2- yl .hutyll-8-(3-hvdroxyphenvn-pyrazinor2'.3':4.51thienor3.2-d1pyrimidine-2.4(lH.3m-dione The product of Example 16 (0.07 g,0.105 mmol) and 3-(benzyloxy)benzeneboronic acid were treated as described in example 106 to yield 0.03g(43%) of benzyl-protected product. To the solution of this product(0.015 g, 0.02 mmol) in CH3COOH a few drops of H2SO4 were added and the solution was refluxed for 0.5 h. The reaction mixture was cooled, neutraUzed and extracted with CH2CI2/CH3OH to yield 0.003g (26%) of the title compound iH NMR (500 MHz, CDCI3) d 1.81 (m, 2H), 1.98 (m, 2H), 2.25 (m, IH), 2.62 (m, IH), 2.85 (m, IH), 3.03 (m, 2H), 3.25(m, 2H), 3.8 (s, 3H), 3.82 (m, 2H), 4.0 (m, 2H), 4.42 (m, IH), 6.52 (m, 3H), 7.12 (m, 3H), 7.42 (t, IH), 7.85 (s, 1H),9.11 (s, IH); MS(ESI)m e 572 (M+H)+ Example 108 3-r4-rf3aR.9hR.-d.γ-9-Methoxy-1.2.3.3a.4.9b-hexahvdro-rn-henzopyranor3.4-c1pvrro1-2- yl .hutyn-8-(4-hvdroxyphenylVpyrazinor2'.3':4.51thienor3.2-dlpyrimidine-2.4(lH.3H>-dinne The product of Example 16 (0.07 g,0.105 mmol) and 4-(mefhoxymethyloxy) phenyl boronic acid (0.02 g, 0.11 mmol) prepared by the procedure described in Tetr.Lett., 21, 27, (199 ) were treated as described in Example 106 to yield 0.029g(45%) of MOM-protected product. To the solution of this product (O.llg, 0.17 mmol) in CH3OH/THF was added 2N HCl (0.2ml) and the reaction mixmre was refluxed for 1 hour. The reaction was evaporated and partitioned in NaHCO3 sol. and CH2CI2/CH3OH to yield 0.005 g (51 %) of the title compound. iH NMR (500 MHz, CDCI3) d 1.81 (m, 2H), 1.98 (m, 2H), 2.25 (m, IH), 2.65 (m, IH), 2.88 (m, IH), 3.08 (m, 2H), 3.22(m, 2H), 3.65 (m, IH), 3.73 (m, IH), 3.82 (s, 3H), 3.9 (m, IH), 4.25 (m, IH), 4.42 (m, IH), 6.52 (m, 2H), 7.38 (m, 2H),7.49(m, IH), 7.9 (t, IH), 8.09 (d, 1H),9.12 (s, IH); MS(ESI)m/e 572 (M+H)+- The foregoing is merely Ulustrative of the invention and is not intended to limit the invention to the disclosed compounds. Nariations and changes which are obvious to one skUled in the art are intended to be within the scope and namre of the invention which are defined in die appended claims.

Claims: WE CLAIM: A compound of formula I: I or a pharmaceutically acceptable salt, ester, or prodrug thereof, wherein Rx and R2 are independently selected from die group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, and R3 is selected from the group consisting of, wherein G and G' are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independently selected from the group consisting of oxygen, nitrogen, and sulfur, with the proviso that when Y is oxygen or sulfur, G is absent and when Y' is oxygen or sulfur, G' is absent, V and V are independentiy selected from the group of nitrogen and methine and U is a ring that is fused to its adjacent ring and is selected from the group consisting of (a) an unsubstituted or substituted five member ring having five carbon atoms; (b) an unsubstituted or substituted five membered ring having four carbon atoms and one heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur; (c) an unsubstituted or substituted five membered ring having three carbon atoms and two heteroatoms independentiy selected from the group consisting of nitrogen, oxygen, and sulfur; (d) a substituted or unsubstituted six membered ring having six carbon atoms; (e) a substituted or unsubstimted six membered ring having 5 carbon atoms and one heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur; (f) a substituted or unsubstitued 6 membered ring having 4 carbon atoms and two heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur; and (g) a substituted or unsubstimted 6 membered ring having three carbon atoms and tiiree heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur. The five membered rings constituting U may contain 0,1, or 2 double bonds. The six membered rings constituting U may contain 0, 1, 2, or 3 double bonds. The rings (a)- (g) of the group constituting U may be mono or di-substituted with substituents indepedently selected from the group consisting of alkyl, alkoxy, cyano, nitro, carboxy, alkoxycarbonyl of two to eight carbon atoms, halogen, cycloalkyl, aryl, and heterocycUc; or a pharmaceutically acceptable salt, ester, or prodrug thereof. 2. A compound of claim 1 wherein said five and six membered ring comprising U contains at least 1 double bond. A compound according to Claim 1 of formula II: π 5 wherein Rx and R2 are independentiy selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, G and G' are independently selected from the group consisting of o hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independently selected from the group consisting of oxygen, nitrogen, and sulfur, with the proviso that when Y is oxygen or sulfur, G is absent and when Y' is oxygen or sulfur, G' is absent, 5 P', Q, S', and T are independently selected from die group consisting of nitrogen and methine, with the proviso that no more than two of P', Q, S', and T can be nitrogen, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocycUc; or a pharmaceutically acceptable salt, ester, or prodrug thereof. 4. A compound according to Claim 1 of the formula UI: in wherein Rl and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, G and G' are independently selected from the group consisting hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independentiy selected from the group consisting of oxygen, nitrogen, and sulfur, with the proviso that when Y is oxygen or sulfur, G is absent and when Y' is oxygen or sulfur, G' is absent, P' and T are nitrogen, Q and S' are methine, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceuticaUy acceptable salt, ester, or prodrug thereof. A compound according to Claim 1 of formula IV: IV wherein Rx and R2 are independentiy selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, G and G' are independently selected from the group consisting hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independentiy selected from the group consisting of oxygen, nitrogen, and sulfur, with the proviso that when Y is oxygen or sulfur, G is absent and when Y' is oxygen or sulfur, G' is absent, P' is nitrogen, Q, S', and T are metiiine, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. A compound according to Claim 1 of formula V: V 5 wherein Rx and R2 are independentiy selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, G and G' are independently selected from the group consisting hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, o hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independentiy selected from the group consisting of oxygen, nitrogen, and sulfur, with the proviso that when Y is oxygen or sulfur, G is absent and when Y' is oxygen or sulfur, G' is absent, Q is nitrogen, P\ S', and T are methine, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a 5 pharmaceutically acceptable salt, ester, or prodrug thereof. 7. A compound according to Claim 1 of formula VI: VI wherein Rl and R2 are independentiy selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, G and G' are independently selected from die group consisting hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independentiy selected from the group consisting of oxygen, nitrogen, and sulfur, wid the proviso that when Y is oxygen or sulfur, G is absent and when Y' is oxygen or sulfur, G 1 is absent, S' is nitrogen, P',Q, and T are methine, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceuticaUy acceptable salt, ester, or prodrug thereof. 8. A compound according to Claim 1 of formula VII: vπ wherein Rx and R2 are independentiy selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, G and G' are independently selected from die group consisting hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independentiy selected from the group consisting of oxygen, nitrogen, and sulfur, with the proviso that when Y is oxygen or sulfur, G is absent and when Y' is oxygen or sulfur, G' is absent, T is nitrogen, P', Q, and S' are methine, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. A compound according to Claim 1 of formula VIE: vm wherein Rx and R2 are independentiy selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, A is methylene, n is 1 or 2, W is alkylene of from 2 to 10 carbon atoms, G and G' are independently selected from the group consisting hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, alkylsulfonyl, and aminoalkyl, Y and Y' are independentiy selected from the group consisting of oxygen, nitrogen, and sulfur, with the proviso that when Y is oxygen or sulfur, G is absent and when Y' is oxygen or sulfur, G' is absent, P 1 , Q, S', and T are methine, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. 10. A compound according to Claim 1 of formula I selected from the group consisting of: 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-chloro-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-chloro-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-methoxy-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-methoxy-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-methoxy-pyrido[3',2':4,5]tiιieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-chloro-ρyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-chloro-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzoρyrano[3,4-c]pyrrol-2- yl)butyl]-8-methoxy-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-methoxy-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-chloro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-isopropoxy-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-phenyl-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[3-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)propyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-8-methoxy-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)- dione, 3-[4-((4aS, 10bR)-trans- 10-Methoxy- 1 ,3,4,4a,5, 10b-hexahydro-2H-[ 1 ]-benzoρyrano[3,4- c]pyrido-3-yl)butyl]-8-metiιoxy-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4(lH,3H)-dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)- dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzoρyrano[3,4- c]pyrido-3-yl)butyl]-8-phenyl-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)- dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-thienyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-pyridyl)-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-pyridyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-pyridyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-furyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, and 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-thienyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, or a pharmaceutically acceptable salt, ester, or prodrug thereof. 11. A compound according to Claim 1 of formula IX: IX wherein Ri and R2 are independentiy selected from the group consisting of hydrogen, and alkoxy, A is methylene, n is 1, W is an alkylene of 2 to 10 carbon atoms, G is hydrogen, G' is absent, Y is nitrogen, Y' is sulfur, P', Q, S', are methine, T is nitrogen, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. 12. A compound of formula DC according to claim 11 wherein said compound is selected from the group of: 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4- c]pyrrol-2-yl)butyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-methoxy-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-chloro-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-isopropoxy-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, and 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-phenyl-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, or a pharmaceutically acceptable salt, ester, or prodrug thereof. 13. A compound according to Claim 1 of formula X: X wherein Ri and R2 are independentiy selected from the group consisting of hydrogen, and alkoxy, A is mediylene, n is 2, W is an alkylene of 2 to 10 carbon atoms, G is hydrogen, G' is absent, Y is nitrogen, Y' is sulfur, P', Q and S', are methine, T is nitrogen, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. 14. A compound of formula X according to claim 13 selected from the group consisting of: 3-[3-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)propyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]- benzopyrano[3,4- c]pyrido-3-yl)butyl]-8-methoxy-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, and 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]- benzoρyrano[3,4- c]pyrido-3-yl)butyl]-8-phenyl-pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, or a pharmaceutically acceptable salt, ester, or prodrug thereof. 15. A compound according to Claim 1 of formula XI: XI wherein Rx and R2 are independentiy selected from the group consisting of hydrogen, and alkoxy, A is methylene, n is 2, W is an alkylene of 2 to 10 carbon atoms, G is hydrogen, G' is absent, Y is nitrogen, Y' is sulfur, Q and S' are methine, P' and T are nitrogen, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. 16. A compound of formula XI according to claim 15 wherein said compound is selected from die group consisting of: 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]-benzopyrano[3,4- c]pyrido-3-yl)butyl]-8-methoxy-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4(lH,3H)-dione, and 3-[4-((4aS,10bR)-trans-10-Methoxy-l,3,4,4a,5,10b-hexahydro-2H-[l]- benzopyrano[3,4- c]pyrido-3-yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, or a pharmaceutically acceptable salt, ester, or prodrug thereof. 17. A compound according to Claim 1 of formula XII: XII wherein Rx and R2 are independentiy selected from die group consisting of hydrogen, and alkoxy, A is methylene, n is 1, W is an alkylene of 2 to 10 carbon atoms, G is hydrogen, G' is absent, Y is nitrogen, Y' is sulfur, Q and S', are methine, P' and T are nitrogen, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. 18. A compound of formula XII according to claim 17 wherein said compound is selected from me group consisting of: 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4- c]pyrrol-2- yl)butyl]-8-chloro-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4- c]pyrrol-2- yl)butyl]-8-chloro-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-methoxy-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4- c]pyrrol-2- yl)butyl]-8-methoxy-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzoρyrano[3,4- c]pyrrol-2- yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4( lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-thienyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-pyridyl)-pyrido[2 , ,3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-pyridyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-pyridyl)-pyrazino[2',3 , :4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Me_hoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-furyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-thienyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-(-cw-7-Hydroxy-9-methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-c _y-6-Hydroxy-9-methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4- c]pyrrol-2-yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)- dione, 3-[4-((3aR,9bR)-cw-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(2-hydroxyphenyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-c 5'-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(3-hydroxyphenyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4(lH,3H)-dione, and 3-[4-((3aR,9bR)-cw-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-(4-hydroxyphenyl)-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine- 2,4(lH,3H)-dione, or a pharmaceutically acceptable salt, ester, or prodrug thereof. 19. A compound according to Claim 1 of formula XIII: xm wherein Ri and R2 are independentiy selected from the group consisting of hydrogen, and alkoxy, A is methylene, n is 1, W is an alkylene of 2 to 10 carbon atoms, G is hydrogen, G' is absent, Y is nitrogen, Y' is sulfur, Q,S', and T are methine, P' is nitrogen, and R4 and R5 are independently selected from hydrogen, alkyl, alkoxy, halogen, hydroxy, amino, cycloalkyl, aryl and heterocyclic; or a pharmaceutically acceptable salt, ester, or prodrug thereof. 20. A compound of the formula XIII according to claim 19 wherein said compound is selected from die group consisting of: 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-methoxy-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-chloro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-methoxy-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, and 3-[4-((3aS,9bR)-trans-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-7-chloro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione, or a pharmaceutically acceptable salt, ester, or prodrug thereof. 21. A compound according to Claim 1 of formula XIV: XIV wherein Rp and R2 are independentiy selected from the group consisting of hydrogen, and alkoxy, Y is nitrogen, G is hydrogen, Y' is sulphur, P' and T are nitrogen, and Q is methine, and S' is carbon; or a pharmaceutically acceptable salt, ester, or prodrug thereof. 22. A compound of formula XIV according to claim 21 wherein said compound is 3-[4- ((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione; or a pharmaceuticaUy acceptable salt, ester, or prodrug thereof. 23. A compound of formula XTV according to claim 22 wherein said compound is 3-[4- ((3aR,9bR)-cis-9-Methoxy-l,2,3,3a,4,9b-hexahydro-[l]-benzopyrano[3,4-c]pyrrol-2- yl)butyl]-8-phenyl-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(lH,3H)-dione hydrochloride. 24. A compound according to formula XV: XV wherein Ri and R2 are independentiy selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, and n is 1 or 0; or a pharmaceutically acceptable salt thereof. 25. A compound according to formula XVI: XVI wherein Rx and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, and n is 1 or 0; or a pharmaceutically acceptable salt thereof. 26. A compound according to formula XVII: XVII wherein Rx and R2 are independentiy selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoaUcyl, m is from 2 to 10, and n is 1 or 0; or a pharmaceuticaUy acceptable salt thereof. 27. A compound of claim 24 having formula XVIH: wherein Rp and R2 are independentiy selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoaUcyl, and n is 1 or 0; or a pharmaceutically acceptable salt thereof. 28. A compound of claim 27 wherein the absolute stereochemistry is 3aR and 9bR. 29. A compound of claim 25 having formula XIX: XIX wherein Rl and R2 are independentiy selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoaUcyl, and n is 1 or 0; or a pharmaceutically acceptable salt thereof. 30. A compound of claim 29 wherein the absolute stereochemistry is 3aR and 9bR. 31. A compound of claim 26 having formula XX: 70 XX wherein Rp and R2 are independentiy selected from the group consisting of hydrogen, alkyL 75 alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkoxycarbonyl, hydroxy, hydroxyalkyl, carboxy, carboxyalkyl, halogen, nitro, amino, and aminoalkyl, m is from 2 to 10, and n is 1 or 0; or a pharmaceuticaUy acceptable salt thereof. 80 32. A compound of claim 31 wherein the absolute stereochemistry is 3aR and 9bR. 33. A compound according to formula XXI: XXI wherein U, Y', G' are as defined in formulae I-XIV and R is alkyl; or a pharmaceutically acceptable salt thereof. 90 34. A compound according to formula XXII: 95 XXII wherein U, Y\ G' are as defined in formulae I-XIV and R alkyl; or a pharmaceutically acceptable salt thereof. 100 35. A compound according to formula XXITI: 105 wherein U, Y\ G', and m are as defined in formulae I-XIV and R is alkyl; or a pharmaceuticaUy acceptable salt thereof. 36. A compound according to formula XXIV: wherein Rz is alkyl. 37. A compound according to Formula XXV: , wherein Rz is alkyl. 38. A compound according to Formula XXVI: wherein X is halogen and R is selected from alkyl and arylalkyl. 39. A compound according to formula XXVII: 110 40. A compound according to formula XXVIII: 115 41. A compound according to formula XXK: 42. A pharmaceutical composition comprising a therapeuticaUy effective amount of a compound of Claim 1 in combination with a pharmaceutically acceptable carrier. 43. A pharmaceutical composition comprising a therapeutically effective amount of a compound of Claim 22 in combination with a pharmaceutically acceptable carrier 44. A method of antagonizing α-1 adrenoreceptors in a host mammal in need of such treatment comprising administering a dierapeuticaUy effective amount of a compound of Claim 1. 45. A method of antagonizing α-1 adrenoreceptors in a host mammal in need of such treatment comprising administering a therapeutically effective amount of a compound of Claim 22. 46. A method of treating benign prostatic hypeφlasia (BPH) in a host mammal in need of such treatment comprising administering a therapeuticaUy effective amount of a compound of Claim 1. 47. A method of treating benign prostatic hypeφlasia (BPH) in a host mammal in need of such treatment comprising administering a therapeutically effective amount of a compound of Claim 22. 48. A method of treating bladder oudet obstruction (BOO) in a host mammal in need of such treatment comprising administering a therapeutically effective amount of a compound of Claim 1. 49. A method of treating bladder oudet obstruction (BOO) in a host mammal in need of such treatment comprising administering a therapeuticaUy effective amount of a compound of Claim 22. 50. A method of treating neurogenic bladder in a host mammal in need of such treatment comprising administering a therapeuticaUy effective amount of a compound of Claim 1. 51. A method of treating neurogenic bladder in a host mammal in need of such treatment comprising administering a therapeuticaUy effective amount of a compound of Claim 22. 52. A method of treating uterine smooth muscle contraction in a host mammal in need of such treatment comprising administering a therapeuticaUy effective amount of a compound of Claim 1. 53. A method of treating uterine smooth muscle contraction in a host mammal in need of such treatment comprising administering a therapeuticaUy effective amount of a compound of Claim 22. 54. A process for preparing a compound of Formula I 120 or a pharmaceutically acceptable salt, ester, or prodrug thereof, wherein R,, R 2 , A, n, W, Y, G, Y\ G', P, Q, S, T, R 4 , and R s are as previously defined; comprising the steps of: a) reacting a compound of the formula wherein Ra is aminoalkyl, b) with a compound of the formula wherein R is alkyl.

Inventors: ALTENBACH ROBERT J, BASHA FATIMA, CARROLL WILLIAM A, DRIZIN IRENE, HAIGHT ANTHONY R, KERWIN JAMES F, MEYER MICHAEL D, WENDT MICHAEL D, ZHANG WEIJIANG, ALTENBACH, ROBERT, J., BASHA, FATIMA, CARROLL, WILLIAM, A., DRIZIN, IRENE, HAIGHT, ANTHONY, R., KERWIN, JAMES, F., MEYER, MICHAEL, D., WENDT, MICHAEL, D., ZHANG, WEIJIANG
Applicants: ABBOTT LAB, ABBOTT LABORATORIES
Application year: 1997
Main classification: C07D491
IPC codes: A61K31, A61P13, A61P15, A61P43, C07D207, C07D311, C07D491, C07D495, C07D519