PENTAFLUOROBENZENESULFONAMIDES AND ANALOGS

Abstract: The invention provides methods and compositions relating to novel pentafluorobenzenesulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of general formula (I).

Description: Pentqfluorobenzenesulfonamides and Analogs Inventors: David Clark, John Flygare, Julio C. Medina, Terry Rosen, and Bei Shan. INTRODUCTION Field of the Invention The field of the invention is pentafluorobenzenesulfonamide derivatives and analogs and their use as pharmacologically active agents. Background Atherosclerosis is a leading cause of death in the United States. The disease results from excess cholesterol accumulation in the arterial walls which forms plaques that inhibit blood flow and promote clot formation, ultimately causing heart attacks, stroke and claudication. The principal source of these cholesterol deposits are low-density lipoprotein (LDL) particles that are present in the blood. There is a direct correlation between LDL concentration and plaque formation in the arteries. LDL concentration is itself largely regulated by the supply of active LDL cell surface receptors which bind LDL particles and translocate them from the blood into the cell interior. Accordingly, the regulation of LDL receptor expression provides an important therapeutic target. Lipoprotein disorders have been previously called the hyperlipoproteinemias and defined as elevation of a lipoprotein level above normal. The hyperlipoproteinemias result in elevations of cholesterol, triglycerides or both and are clinically important because of their contribution to atherosclerotic diseases and pancreatitis. Lipoproteins are spherical macromolecular complexes of lipid and protein. The lipid constituents of lipoproteins are esterified and unesterified (free) cholesterol, triglycerides, and phospholipids. Lipoproteins transport cholesterol and triglycerides from sites of absorption and synthesis to sites of utilization. Cholesteryl ester and triglycerides are nonpolar and constitute the hydrophobic core of lipoproteins in varying proportions. The lipoprotein surface coat contains the polar constituents - free cholesterol, phospholipids, and apolipoproteins - that permit these particles to be miscible in plasma. Cholesterol is used for the synthesis of bile acids in the liver, the manufacture and repair of cell membranes, and the synthesis of steroid hormones. There are both exogenous and endogenous sources of cholesterol. The average American consumes about 450 mg of cholesterol each day and produces an additional 500 to 1 ,000 mg in the liver and other tissues. Another source is the 500 to 1,000 mg of biliary cholesterol that is secreted into the intestine daily; about 50 percent is reabsorbed (enterohepatic circulation). The rate-limiting enzyme in endogenous cholesterol synthesis is 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Triglycerides, which are nonpolar lipids consisting of a glycerol backbone and three fatty acids of varying length and degrees of saturation, are used for storage in adipose tissue and for energy. Lipoproteins are classified into groups based upon size, density, electrophoretic mobility, and lipid and protein composition. Very low density lipoproteins (VLDL) are large, triglyceride-rich lipoproteins that are synthesized and secreted by hepatocytes. VLDL interacts with lipoprotein lipase in capillary endothelium, and the core triglycerides are hydrolyzed to provide fatty acids to adipose and muscle tissue. About half of the catabolized VLDL particles are taken up by hepatic LDL receptors and the other half remain in plasma, becoming intermediate-density lipoprotein. IDL is enriched in cholesteryl ester relative to triglyceride and is gradually converted by hepatic triglyceride lipase to the smaller, denser, cholesterol ester-rich LDL. As IDL is converted to LDL, apolipoprotein E becomes detached, and only one apolipoprotein remains, apo B-100. LDL normally carries about 75 percent of the circulating cholesterol. Cellular LDL uptake is mediated by a glycoprotein receptor molecule that binds to apo B-100. Approximately 70 percent of LDL is cleared by receptor uptake, and the remainder is removed by a scavenger cell pathway using nonreceptor mechanisms. The LDL receptors span the thickness of the cell's plasma membrane and are clustered in specialized regions where the cell membrane is indented to form craters called coated pits. These pits invaginate to form coated vesicles, where LDL is separated from the receptor and delivered to a lysosome so that digestive enzymes can expose the cholesteryl ester and cleave the ester bond to form free cholesterol. The receptor is recycled to the cell surface. As free cholesterol liberated from LDL accumulates within cells, there are three important metabolic consequences. First, there is a decrease in the synthesis of HMG-CoA reductase, the enzyme that controls the rate of de novo cholesterol synthesis by the cell. Second, there is activation of the enzyme acyl cholesterol acyltransferase (ACAT), which esterifies free cholesterol into cholesterol ester, the cell's storage form of cholesterol. Third, accumulation of cholesterol suppresses the cell's synthesis of new LDL receptors. This feedback mechanism reduces the cell's uptake of LDL from the circulation. Lipoproteins play a central role in atherogenesis. This association with the most common cause of death in the developed world defines the principal clinical importance of the hyperlipoproteinemias. Individuals with an elevated cholesterol level are at higher risk for atherosclerosis. Multiple lines of evidence, including epidemiological, autopsy, animal studies and clinical trials, have established that LDL is atherogenic and that the higher the LDL level, the greater the risk of atherosclerosis and its clinical manifestations. A certain level of LDL elevation appears to be a necessary factor in the development of atherosclerosis, although the process is modified by myriad other factors (e.g., blood pressure, tobacco use, blood glucose level, antioxidant level, and clotting factors). Acute pancreatitis is another major clinical manifestation of dyslipoproteinemia. It is associated with chylomicronemia and elevated VLDL levels. Most patients with acute pancreatitis have triglyceride levels above 2,000 mg/dL, but a 1983 NIH consensus development conference recommended that prophylactic treatment of hypertriglyceridemia should begin when fasting levels exceed 500 mg/dL. The mechanism by which chylomicronemia and elevated VLDL cause pancreatitis is unclear. Pancreatic lipase may act on triglyceride in pancreatic capillaries, resulting in the formation of toxic fatty acids that cause inflammation. Abundant evidence indicates that treatment of hyperlipoproteinemia will diminish or prevent atherosclerotic complications. In addition to a diet that maintains a normal body weight and minimizes concentrations of lipids in plasma, therapeutic agents that lower plasma concentrations of lipoproteins, either by diminishing the production of lipoproteins or by enhancing the efficiency of their removal from plasma, are clinically important. The most promising class of drugs currently available for the treatment of hyperlipoproteinemia or hypercholesterolemia acts by inhibiting HMG-CoA reductase, the rate-limiting enzyme in endogenous cholesterol synthesis. Drugs of this class competitively inhibit the activity of the enzyme. Eventually, this inhibition leads to a decrease in the endogenous synthesis of cholesterol and by normal homeostatic mechanisms, plasma cholesterol is taken up by LDL receptors to restore the intracellular cholesterol balance. Through both the release of precursors of LDL and receptor-mediated LDL uptake from the serum, liver cells play a critical role in maintaining serum cholesterol homeostasis. In both man and animal models, an inverse correlation appears to exist between liver LDL receptors and LDL-associated serum cholesterol levels. In general, higher hepatocyte receptor numbers result in lower LDL-associated serum cholesterol levels. Cholesterol released into hepatocytes can be stored as cholesteryl esters, converted into bile acids and released into the bile duct, or enter into an oxycholesterol pool. It is this oxycholesterol pool that is believed to be involved in end product repression of both the genes of the LDL receptor and enzymes involved in the cholesterol synthetic pathway. Transcription of the LDL receptor gene is known to be repressed when cells have an excess supply of cholesterol, probably in the form of oxycholesterol. A DNA sequence in the LDL receptor promoter region, known as the sterol response element (SRE), appears to confer this sterol end product repression. This element has been extensively investigated (Brown, Goldstein and Russell, U.S. Patents 4,745,060 and 4,935,363). The SRE can be inserted into genes that normally do not respond to cholesterol, conferring sterol end product repression of the chimeric gene. The exact mechanism of the repression is not understood. Brown and Goldstein have disclosed methods for employing the SRE in a screen for drugs capable of stimulating cells to synthesize LDL receptors (U.S. Patent 4,935,363). It would be most desirable if the synthesis of LDL receptors could be upregulated at the level of gene expression. The upregulation of LDL receptor synthesis at this level offers the promise of resetting the level of serum cholesterol at a lower, and clinically more desirable, level. Presently, however, there are no cholesterol lowering drugs that are known to operate at the level of gene expression. The present invention describes methods and compounds that act to inhibit directly or indirectly the repression of the LDL receptor gene, resulting in induction of the LDL receptor on the surface of liver cells, facilitating LDL uptake, bile acid synthesis and secretion to remove cholesterol metabolites and hence the lowering of LDL-associated serum cholesterol levels. Accordingly, it is one object of the present invention to provide compounds which directly or indirectly upregulate LDL receptor synthesis at the level of gene expression and are useful in the treatment of hypercholesterolemia or hyperlipoproteinemia. A further object of the present invention is to provide therapeutic compositions for treating said conditions. A further object of the invention is to provide therapeutic compositions for treating pancreatitis. Still further objects are to provide methods for upregulating LDL receptor synthesis, for lowering serum LDL cholesterol levels, and for inhibiting atherosclerosis. Other objects, features and advantages will become apparent to those skilled in the art from the following description and claims. SUMMARY OF THE INVENTION The invention provides methods and compositions relating to novel pentafluorobenzenesulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly hypercholesterolemia and atherosclerosis, or as lead compounds for the development of such agents. In one embodiment, the invention provides for the pharmaceutical use of compounds of the general formula I and for pharmaceutically acceptable compositions of compounds of formula I: or a physiologically acceptable salt thereof, wherein: Y is -S(O)- or -S(O) 2 -; Z is -NR1R2 or -OR3, where Rl and R2 are independently selected from hydrogen, substituted or unsubstituted (Cl-ClO)alkyl, substituted or unsubstituted (C 1 -C 10)alkoxy , substituted or unsubstituted (C3-C6)alkenyl, substituted or unsubstituted (C2-C6)heteroalkyl, substituted or unsubstituted (C3-C6)heteroalkenyl, substituted or unsubstituted (C3-C6)alkynyl, substituted or unsubstituted (C3-C8)cycloalkyl, substituted or unsubstituted (C5-C7)cycloalkenyl, substituted or unsubstituted (C5-C7)cycloalkadienyl, substituted or unsubstituted aryl, substituted or unsubstituted aryloxy, substituted or unsubstituted aryl-(C3-C8)cycloalkyl, substituted or unsubstituted aryl-(C5-C7)cycloalkenyl, substituted or unsubstituted aryloxy-(C3-C8)cycloalkyl, substituted or unsubstituted aryl-(Cl-C4)alkyl, substituted or unsubstituted aryl-(Cl-C4)alkoxy, substituted or unsubstituted aryl-(Cl-C4)heteroalkyl, substituted or unsubstituted aryl-(C3-C6)alkenyl, substituted or unsubstituted aryloxy-(Cl-C4)alkyl, substituted or unsubstituted aryloxy-(C2-C4)heteroalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaryloxy, substituted or unsubstituted heteroaryl-(Cl-C4)alkyl, substituted or unsubstituted heteroaryl-(Cl-C4)alkoxy, substituted or unsubstituted heteroaryl-(C 1 -C4)heteroalkyl, substituted or unsubstituted heteroaryl-(C3-C6)alkenyl, substituted or unsubstituted heteroaryloxy-(Cl-C4)alkyl, and substituted or unsubstituted heteroaryloxy-(C2-C4)heteroalkyl, wherein R 1 and R 2 may be connected by a linking group E to give a substituent of the formula wherein E represents a bond, (C 1 -C4) alkylene, or (C 1 -C4) heteroalkylene, and the ring formed by R 1 , E, R 2 and the nitrogen contains no more than 8 atoms, or preferably the R 1 and R 2 may be covalently joined in a moiety that forms a 5- or 6-membered heterocyclic ring with the nitrogen atom of NR'R 2 ; and where R 3 is a substituted or unsubstituted aryl or heteroaryl group. Substituents for the alkyl, alkoxy, alkenyl, heteroalkyl, heteroalkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, and cycloalkadienyl radicals are selected independently from -H -OH -O-(C1-C10)alkyl =O -NH 2 -NH-(C1-C10)alkyl -N[(Cl-C10)alkyl] 2 -SH -S-(C1-C10)alkyl -halo -Si[(Cl-C10)alkyl] 3 in a number ranging from zero to (2N+1), where N is the total number of carbon atoms in such radical. Substituents for the aryl and heteroaryl groups are selected independently from -halo -OH -O-R' -O-C(O)-R' -NH 2 -NHR' -NR'R" -SH -SR' -R' -CN -NO 2 -CO 2 H -CO 2 -R' -CONH 2 -CONH-R' -CONR'R" -O-C(O)-NH-R' -O-C(O)-NR'R" -NH-C(O)-R' -NR"-C(O)-R' -NH-C(O)-OR' -NR"-C(O)-R' -NH-C(NH 2 )=NH -NR'-C(NH 2 )=NH -NH-C(NH 2 )=NR' -S(O)-R' -S(O) 2 -R' -S(O) 2 -NH-R' -S(O) 2 -NR'R" "N 3 -CH(Ph) 2 substituted or unsubstituted aryloxy substituted or unsubstituted arylamino substituted or unsubstituted heteroarylamino substituted or unsubstituted heteroaryloxy substituted or unsubstituted aryl-(Cl-C4)alkoxy, substituted or unsubstituted heteroaryl-(Cl-C4)alkoxy, perfluoro(Cl-C4)alkoxy, and perfluoro(Cl-C4)alkyl, in a number ranging from zero to the total number of open valences on the aromatic ring system; and where R' and R" are independently selected from : substituted or unsubstituted (Cl-ClO)alkyl, substituted or unsubstituted (Cl-ClO)heteroalkyl, substituted or unsubstituted (C2-C6)alkenyl, substituted or unsubstituted (C2-C6)heteroalkenyl, substituted or unsubstituted (C2-C6)alkynyl, substituted or unsubstituted (C3-C8)cycloalkyl, substituted or unsubstituted (C3-C8)heterocycloalkyl, substituted or unsubstituted (C5-C6)cycloalkenyl, substituted or unsubstituted (C5-C6)cycloalkadienyl, substituted or unsubstituted aryl, substituted or unsubstituted aryl-(Cl-C4)alkyl, substituted or unsubstituted aryl-(Cl-C4)heteroalkyl, substituted or unsubstituted aryl-(C2-C6)alkenyl, substituted or unsubstituted aryloxy-(Cl-C4)alkyl, substituted or unsubstituted aryloxy-(Cl-C4)heteroalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaryl-(Cl-C4)alkyl, substituted or unsubstituted heteroaryl-(C 1 -C4)heteroalkyl, substituted or unsubstituted heteroaryl-(C2-C6)alkenyl, substituted or unsubstituted heteroaryloxy-(Cl-C4)alkyl, and substituted or unsubstituted heteroaryloxy-(Cl-C4)heteroalkyl. Two of the substituents on adjacent atoms of the aryl or heteroaryl ring may optionally be replaced with a substituent of the formula -T-C(O)-(CH 2 ) n -U-, wherein T and U are independently selected from N, O, and C, and n = 0-2. Alternatively, two of the substituents on adjacent atoms of the aryl or heteroaryl ring may optionally be replaced with a substituent of the formula -A-(CH2)p-B-, wherein A and B are independently selected from C, O, N, S, SO, SO 2 , and SO 2 NR', and p = 1-3. One of the single bonds of the new ring so formed may optionally be replaced with a double bond. Alternatively, two of the substituents on adjacent atoms of the aryl or heteroaryl ring may optionally be replaced with a substituent of the formula -(CH 2 ) -X- (CH 2 ) r -, where q and r are independently 1-3, and X is selected from O. N, S, SO, SO 2 and SO 2 NR'. The substituent R' in SO 2 NR' is selected from hydrogen or (C 1 -C6)alkyl. In another embodiment, the invention provides novel methods for the use of pharmaceutical compositions containing compounds of the foregoing description of the general formula I. The invention provides novel methods for treating pathology such as hypercholesterolemia, atherosclerosis, pancreatitis, and hyperlipoproteinemia, including administering to a patient an effective formulation of one or more of the subject compositions. In another embodiment, the invention provides chemically-stable, pharmacologically active compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein: Y is -S(O)- or -S(O 2 )-; and Z is NR*R 2 , wherein R 2 is an optionally substituted aryl or heteroaryl group, and R 1 is selected from: hydrogen, substituted or unsubstituted (C 1 -C 10)alky 1, substituted or unsubstituted (Cl-ClO)alkoxy, substituted or unsubstituted (C3-C6)alkenyl, substituted or unsubstituted (C2-C6)heteroalkyl, substituted or unsubstituted (C3-C6)heteroalkenyl, substituted or unsubstituted (C3-C6)alkynyl, substituted or unsubstituted (C3-C8)cycloalkyl, substituted or unsubstituted (C5-C7)cycloalkenyl, substituted or unsubstituted (C5-C7)cycloalkadienyl, substituted or unsubstituted aryl, substituted or unsubstituted aryloxy, substituted or unsubstituted aryl-(C3-C8)cycloalkyl, substituted or unsubstituted aryl-(C5-C7)cycloalkenyl, substituted or unsubstituted aryloxy-(C3-C8)cycloalkyl, substituted or unsubstituted aryl-(Cl-C4)alkyl, substituted or unsubstituted aryl-(Cl-C4)alkoxy, substituted or unsubstituted aryl-(Cl-C4)heteroalkyl, substituted or unsubstituted aryl-(C3-C6)alkenyl, substituted or unsubstituted aryloxy-(Cl-C4)alkyl, substituted or unsubstituted aryloxy-(C2-C4)heteroalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaryloxy, substituted or unsubstituted heteroaryl-(Cl-C4)alkyl, substituted or unsubstituted heteroaryl-(Cl-C4)alkoxy, substituted or unsubstituted heteroaryl-(Cl-C4)heteroalkyl, substituted or unsubstituted heteroaryl-(C3-C6)alkenyl, substituted or unsubstituted heteroaryloxy-(Cl-C4)alkyl, and substituted or unsubstituted heteroaryloxy-(C2-C4)heteroalkyl, wherein R 1 and R 2 may be connected by a linking group E to give a substituent of the formula wherein E represents a bond, (C1-C4) alkylene, or (C1-C4) heteroalkylene, and the ring formed by R 1 , E, R 2 and the nitrogen contains no more than 8 atoms, or preferably the R 1 and R 2 may be covalently joined in a moiety that forms a 5- or 6-membered heterocyclic ring with the nitrogen atom of NR'R 2 ; provided that: in the case that Y is -S(O 2 )-, and R 1 is hydrogen or methyl, then R 2 is substituted phenyl or heteroaryl group; in the case that Y is -S(O 2 )- and R 2 is a ring system chosen from 1 -naphthyl, 5-quinolyl, or 4-pyridyl, then either Rl is not hydrogen or R2 is substituted by at least one substituent that is not hydrogen; in the case that Y is -S(O 2 )-, R 2 is phenyl, and R 1 is a propylene unit attaching the nitrogen of -NR'R 2 - to the 2- position of the phenyl ring in relation to the sulfonamido group to form a 1,2,3,4-tetrahydroquinoline system, one or more of the remaining valences on the bicyclic system so formed is substituted with at least one substituent that is not hydrogen; in the case that Y is -S(O 2 )- and R 2 is phenyl substituted with 3-(l-hydroxyethyl), 3-dimethylamino, 4-dimethylamino, 4-phenyl, 3-hydroxy, 3-hydroxy-4-die ylaminomethyl, 3,4-methylenedioxy, 3,4-ethylenedioxy, 2-(l-pyrrolyl), or 2-methoxy-4-(l-morpholino), then either R 1 is not hydrogen or when R 1 is hydrogen, one or more of the remaining valences on the phenyl ring of R 2 is substituted with a substituent that is not hydrogen; in the case that Y is -S(O 2 )- and R 2 is 2-methylbenzothiazol-5-yl, 6-hydroxy-4-methyl-pyrimidin-2-yl, 3-carbomethoxypyrazin-2-yl, 5-carbomethoxypyrazin-2-yl, 4-carboethoxy- l-phenylpyrazol-5-yl, 3-methylpyrazol-5-yl, 4-chloro-2-methylthiopyrimidin-6-yl, 2-trifluoromethyl-l,3,4-thiadiazol-5-yl, 5,6,7,8- tetrahydro-2-naphthyl, 4-methylthiazol-2-yl, 6,7-dihydroindan-5-yl, 7-chloro-5-methyl-l,8- naphthyridin-2-yl, 5,7-dimethyl-l,8-naphthyridin-2-yl, or 3-cyanopyrazol-4-yl, R 1 is a group other than hydrogen. DETAILED DESCRIPTION OF THE INVENTION The term "alkyl" by itself or as part of another substituent means, unless otherwise stated, a straight or branched chain hydrocarbon radical, including di- and multi-radicals, having the number of carbon atoms designated (i.e. C 1 -C 10 means one to ten carbons) and includes straight or branched chain groups such as methyl, ethyl, n-propyl, isopropyl, n-butyl, t-butyl, isobutyl, sec-butyl, homologs and isomers of n-pentyl, n-hexyl, 2-methylpentyl, 1,5-dimethylhexyl, l-methyl-4-isopropylhexyl and the like. The term "alkylene" by itself or as part of another substituent means a divalent radical derived from an alkane, as exemplified by -CH 2 CH 2 CH 2 CH 2 -. A "lower alkyl" is a shorter chain alkyl, generally having six or fewer carbon atoms. The term "heteroalkyl" by itself or in combination with another term means, unless otherwise stated, a stable straight or branched chain radical consisting of the stated number of carbon atoms and one or two heteroatoms selected from the group consisting of O, N, and S, and wherein the nitrogen and sulfur atoms may optionally be oxidized and the nitrogen heteroatom may optionally be quaternized. The heteroatom(s) may be placed at any position of the heteroalkyl group, including between the rest of the heteroalkyl group and the fragment to which it is attached, as well as attached to the most distal carbon atom in the heteroalkyl group. Examples include -O-CH 2 -CH 2 -CH 3 , -CH 2 -CH 2 -O-CH 3 , -CH 2 -CH 2 -CH 2 -OH, -CH 2 -CH 2 -NH-CH 3 , -CH 2 -CH 2 -N(CH 3 )-CH 3 , -CH 2 -S-CH 2 -CH 3 , -CH 2 -CH 2 -S(O)-CH 3 , -O-CH 2 -CH 2 -CH 2 -NH-CH 3 , and -CH 2 -CH 2 -S(O) 2 -CH 3 . Up to two heteroatoms may be consecutive, such as, for example, -CH 2 -NH-OCH 3 . The term "heteroalkylene" by itself or as part of another substituent means a divalent radical derived from heteroalkyl, as exemplified by -CH 2 -CH 2 -S-CH 2 -CH 2 - and -CH 2 -S-CH 2 -CH 2 -NH-. The terms "cycloalkyl" and "heterocycloalkyl", by themselves or in combination with other terms, represent, unless otherwise stated, cyclic versions of "alkyl" and "heteroalkyl", respectively. Examples of cycloalkyl include cyclopentyl, cyclohexyl, cycloheptyl, and the like. Examples of heterocycloalkyl include 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-morpholinyl, 3-morpholinyl, tetrahydrofuran-2-yl, tetrahydrofuran-3-yl, tetrahydrothien-2-yl, tetrahydrothien-3-yl, 1-piperazinyl, 2-piperazinyl, and the like. The term "alkenyl" employed alone or in combination with other terms, means, unless otherwise stated, a stable straight chain or branched monounsaturated or diunsaturated hydrocarbon group having the stated number of carbon atoms. Examples include vinyl, propenyl (allyl), crotyl, isopentenyl, butadienyl, 1 ,3-pentadienyl, 1,4-pentadienyl, and the higher homologs and isomers. A divalent radical derived from an alkene is exemplified by -CH=CH-CH 2 -. The term "heteroalkenyl" by itself or in combination with another term means, unless otherwise stated, a stable straight or branched chain monounsaturated or diunsaturated hydrocarbon radical consisting of the stated number of carbon atoms and one or two heteroatoms selected from the group consisting of O, N, and S, and wherein the nitrogen and sulfur atoms may optionally be oxidized and the nitrogen heteroatom may optionally be quarternized. Up to two hetero atoms may be placed consecutively. Examples include -CH=CH-O-CH 2 -, -CH=CH-CH 2 -O-, -CH 2 -CH=N-OCH 3 -, -CH=CH-N(CH 3 )-CH 2 -, and -CH 2 -CH=CH-CH 2 - SH. The term "alkynyl" employed alone or in combination with other terms, means, unless otherwise stated, a stable straight chain or branched hydrocarbon group having the stated number of carbon atoms, and containing one or two carbon-carbon triple bonds, such as ethynyi, 1- and 3-propynyl, 4-but-l-ynyl, and the higher homologs and isomers. The term "alkoxy" employed alone or in combination with other terms, means, unless otherwise stated, an alkyl group, as defined above, connected to the rest of the molecule via an oxygen atom, such as, for example, methoxy, ethoxy, 1-propoxy, 2-propoxy, isopropoxy, and the higher homologs and isomers. The terms "halo" or "halogen" by themselves or as part of another substituent mean, unless otherwise stated, a fluorine, chlorine, bromine, or iodine atom. The term "aryl" employed alone or in combination with other terms, means, unless otherwise stated, a phenyl, 1 -naphthyl, or 2-naphthyl group. The maximal number of substituents allowed on each one of these ring systems is five, seven, and seven, respectively. Substituents are selected from the group of acceptable substituents listed above. The term "heteroaryl" by itself or as part of another substituent means, unless otherwise stated, an unsubstituted or substituted, stable, mono- or bicyclic heterocyclic aromatic ring system which consists of carbon atoms and from one to four heteroatoms selected from the group consisting of N, O, and S, and wherein the nitrogen and sulfur heteroatoms may optionally be oxidized, and the nitrogen atom may optionally be quaternized. The heterocyclic system may be attached, unless otherwise stated at any heteroatom or carbon atom which affords a stable structure. The heterocyclic system may be substituted or unsubstituted with one to four substituents independently selected from the list of acceptable aromatic substituents listed above. Examples of such heterocycles include 2-pyrrolyl, 3-pyrrolyl, 3-pyrazolyl, 2- imidazolyl, 4-imidazolyl, pyrazinyl, 2-oxazolyl, 4-oxazolyl, 5-oxazolyl, 3-isoxazolyl, 4- isoxazolyl, 5-isoxazolyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 2-furyl, 3-furyl, 2-thienyI, 3- thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidyl, 4-pyrimidyl, 5 -benzothiazolyl, purinyl, 2-benzimidazolyl, 5-indolyl, 1-isoquinolinyl, 5-isoquinolyl, 2-quinoxalinyl, 5-quinoxalinyl, 3- quinolinyl, and 6-quinolinyl. Pharmaceutically acceptable salts of the compounds of Formula I include salts of these compounds with relatively nontoxic acids or bases, depending on the particular substituents found on specific compounds of Formula I. When compounds of Formula I contain relatively acidic functionalities, base addition salts can be obtained by contacting the neutral form of compound I with a sufficient amount of the desired base, either neat or in a suitable inert solvent. Examples of pharmaceutically acceptable base addition salts include sodium, potassium, calcium, ammonium, organic amino, or magnesium salt, or a similar salt. When compounds of Formula I contain relatively basic functionalities, acid addition salts can be obtained by contacting the neutral form of compound I with a sufficient amount of the desired acid, either neat or in a suitable inert solvent. Examples of pharmaceutically acceptable acid addition salts include those derived from inorganic acids like hydrochloric, hydrobromic, nitric, carbonic, monohydrogencarbonic, phosphoric, monohydrogenphosphoric, dihydrogenphosphoric, sulfuric, monohydrogensulfuric, hydriodic, or phosphorous acids and the like, as well as the salts derived from relatively nontoxic organic acids like acetic, propionic, isobutyric, oxalic, maleic, malonic, benzoic, succinic, suberic, fumaric, mandelic, phthalic, benzenesulfonic, p-tolylsulfonic, citric, tartaric, rnethanesulfonic, and the like. Also included are salts of amino acids such as arginate and the like, and salts of organic acids like gluconic or galactunoric acids and the like (see, for example, Berge, S.M., et al, "Pharmaceutical Salts", Journal of Pharmaceutical Science, Vol. 66, pages 1-19 (1977)). Certain specific compounds of Formula I contain both basic and acidic functionalities that allow the compounds to be converted into either base or acid addition salts. The free base form may be regenerated by contacting the salt with a base or acid and isolating the parent compound in the conventional manner. The parent form of the compound differs from the various salt forms in certain physical properties, such as solubility in polar solvents, but otherwise the salts are equivalent to the parent form of the compound for the purposes of the present invention. Certain compounds of the present invenuon can exist in unsolvated forms as well as solvated forms, including hydrated forms. In general, the solvated forms are equivalent to unsolvated forms and are intended to be encompassed within the scope of the present invention. Certain compounds of the present invention possess asymmetric carbon atoms (optical centers); the racemates, diastereomers, and individual isomers are all intended to be encompassed within the scope of the present invention. The compounds of the present invention may also contain unnatural proportions of atomic isotopes at one or more of the atoms that constitute such compounds. For example, the compounds may be radiolabeled with radioactive isotopes, such as for example tritium ( 3 H) or carbon- 14 ( , C). All isotopic variations of the compounds of the present invention, whether radioactive or not, are intended to be encompassed within the scope of the present invention. In various preferred embodiments of the pharmaceutical compositions of compounds of formula I, Y is S(O 2 ) and Z is NR'R 2 , wherein R 1 is hydrogen or methyl, and R 2 is a substituted phenyl, preferably mono-, di-, or trisubstituted as follows. In one group of preferred compounds, Y is S(O 2 ) and Z is NR'R 2 , wherein R 1 is hydrogen or methyl, and R 2 is a phenyl group, preferably substituted in the para position by one of the following groups: hydroxy, amino, (Cl-ClO)alkoxy, (Cl-ClO)alkyl, (Cl-ClO)alJ ylamino, and [di(Cl-C10)alkyl]amino, with up to four additional substituents independently chosen from hydrogen, halogen, (Cl-ClO)alkoxy, (Cl-ClO)alkyl, and [di(Cl-C10)alkyl]amino. Also preferred are compounds of formula I where there is no linking group E between R 1 and R 2 . Illustrative examples of pharmaceutical compositions and compounds of the subject pharmaceutical methods include: 3-Fluoro-4-methoxy- 1 -pentafluorophenylsulfinamidobenzene; 4-Dimethy lamino- 1 -pentafluorophenylsulfinamidobenzene; 4-Methyl-6-methoxy-2-pentafluorophenylsulfonamidopyrimidine; 4,6-Dimethoxy-2-pentafluorophenylsulfonamidopyrimidine; 2-Pentafluorophenylsulfonamidothiophene; 3-Pentafluorophenylsulfonamidothiophene; 3-Pentafluorophenylsulfonamidopyridine; 4-Pentafluorophenylsulfonamidopyridine; 4-(N N,-Dimethy lamino)- 1 -(N-ethylpentafluoropheny lsulfonamido)-benzene; 4-tørt-Butoxy- 1 -pentafluorophenylsulfonamidobenzene; 3 -tert-Butoxy- 1 -pentafluorophenylsulfonamidobenzene; 2-terf-Butoxy- 1 -pentafluoropheny lsulfonamidobenzene; 4-Isopropoxy- 1 -pentafluorophenylsulfonamidobenzene; 3-Isopropoxy- 1 -pentafluorophenylsulfonamidobenzene; 2-Isopropoxy- 1 -pentafluorophenylsulfonamidobenzene; 2-Methoxy- 1 ,3-difluoro-5-pentafluorophenylsulfonamidobenzene; 4-Cy clopropoxy- 1 -pentafluorophenylsulfonamidobenzene; 3 -Fluoro-4-cyclopropoxy- 1 - 1 pentafluorophenylsulfonamidobenzene; 3 -Hydroxy-4-cy clopropoxy- 1 -pentafluoropheny lsulfonamidobenzene; l-Hydroxy-2,3-methylenedioxy-5-pentafluorophenylsulfonamidobenzene; l-Hydroxy-2,3-ethylenedioxy-5-pentafluorophenylsulfonamidobenzene; l-Hydroxy-2,3-carbodioxy-5-pentafluorophenylsulfonamidobenzene; 1 ,3 -Dihydroxy-2-ethoxy-5-pentafluoropheny lsulfonamidobenzene ; 1 -Pentafluorophenylsulfonylindole; 1 -Pentafluorophenylsulfony 1(2,3 -dihydro)indole; 1 -PentafluorophenylsulfonyK 1 ,2-dihydro)quinoline; 1 -Pentafluorophenylsulfony 1( 1 ,2,3 ,4-tetrahydro)quinoline; 3 ,4-Difluoro- 1 -pentafluoropheny lsulfonamidobenzene; 4-Trifiuoromethoxy- 1 -pentafluoropheny lsulfonamidobenzene; 2-Chloro-5-pentafluorophenylsulfonamidopyridine; 2-Hydroxy-l-methoxy-4-[N-5-hydroxypent-l-yl)pentafluorophenyl-sulfonamido]benzene; 4-( 1 , 1 -Dimethyl)ethoxy- 1 -pentafluoropheny lsulfonamidobenzene; 1 -Bromo-3-hydroxy-4-methoxy- 1 -pentafluorophenylsulfonamidobenzene; 2-Bromo-4-methoxy-5-hydroxy- 1 -pentafluorophenylsulfonamidobenzene; l-Bromo-4-fluoro-5-methoxy-2-pentafluorophenylsulfonamidobenzene; 3 -Chloro- 1 -pentafluorophenylsulfonamidobenzene; 4-Chloro- 1 -pentafluorophenylsulfonamidobenzene; 3-Nitro- 1 -pentafluoropheny lsulfonamidobenzene; 4-Methoxy- 1 -pentafluorophenylsulfonamido-3-(trifluoromethyl)benzene; 4-Methoxy- 1 -[N-(2-propenyl)pentafluorophenylsulfonamido]benzene; 1 -(N-(3 -Buteny l)pentafluoropheny lsulfonamido)-4-methoxy benzene ; 4-Methoxy- 1 -(N-(4-pentenyl)pentafluorophenylsulfonamido)benzene; 1 -[N-(2,3 -Dihydroxypropyl)pentøfluorophenylsulfonamido]-4-methoxy-benzene ; l-(N-(3,4-Dihydroxybutyl)pentafluorophenylsulfonamido)-4-methoxybenzene; l-(N-(4,5-Dihydroxypentyl)pentafluorophenylsulfonamido)-4-methoxybenzene; l-(N-(4-hydroxybutyl)pentafluorophenylsulfonamido)-4-methoxybenzene; 4-Methoxy-l-(N-(5-hydroxypentyl)pentafluorophenylsulfonamido)-benzene; 3 - Amino-4-methoxy- 1 -pentafluoropheny lsulfonamidobenzene ; 4-Butoxy- 1 -pentafluorophenylsulfonamidobenzene; l-Pentafluorophenylsulfonamido-4-phenoxybenzene; 6-Pentafluorophenylsulfonamidoquinoline; 2,3-Dihydro-5-pentafluorophenylsulfonamidoindole; 5-Pentafluorophenylsulfonamidobenzo[a]thiophene; 5-Pentafluorophenylsulfonamidobenzo[a]furan; 3 -Hy droxy-4-( 1 -propeny 1)- 1 -pentafluoropheny lsulfonamidobenzene ; 4-Benzyloxy- 1 -pentafluorophenylsulfonamidobenzene; 4-Methylmercapto- 1 -pentafluorophenylsulfonamidobenzene; 2-Methoxy- 1 -pentafluoropheny lsulfonamidobenzene; 4-Allyloxy- 1 -pentafluorophenylsulfonamidobenzene; l-Pentafluorophenyisulfonamido-4-propoxybenzene; 4-( 1 -Methy l)ethoxy- 1 -pentafluorophenylsulfonamidobenzene; 1 ,2-Methylenedioxy-4-pentafluoropheny lsulfonamidobenzene; l,2-Dimethoxy-4-pentafluorophenylsulfonamidobenzene; 4-(NN-Diethy lamino)- 1 -pentafluorophenylsulfonamidobenzene; 4- Amino- 1 -pentafluorophenylsulfonamidobenzene; Pentafluorophenylsulfonamidobenzene; 5-Pentafluorophenylsulfonamidoindazole; 4-(N N-Dimethylamino)- 1 -(N-methylpentafluorophenylsulfonamido)-benzene; 1 ,2-Dihydroxy-4-pentafluoropheny lsulfonamidobenzene ; 3 ,5-Dimethoxy- 1 -pentafluorophenylsulfonamidobenzene; 3-Ethoxy- 1 -pentafluorophenylsulfonamidobenzene; 7-Hydroxy-2-pentafluorophenylsulfonamidonaphthalene; 3-Phenoxy- 1 -pentafluoropheny lsulfonamidobenzene; 4-( 1 -Morpholino)- 1 -pentafluoropheny lsulfonamidobenzene; 5-Pentafluorophenylsulfonamido- 1 ,2,3-trimethoxy benzene; 2-Hydroxy- 1 ,3-methoxy-5-pentafluorophenylsulfonamidobenzene; 1 ,2-Dihydroxy-3-methoxy-5-pentafluorophenylsulfonamidobenzene; 5-Pentafluorophenylsulfonamido-l,2,3-trihydroxy benzene; 3 -Hydroxy- 5 -methoxy- 1 -pentafluorophenylsulfonamidobenzene; 3,5-Dihydroxy- 1 -pentafluorophenylsulfonamidobenzene; 2-Fluoro- 1 -methoxy-4-(N-methylpentafluorophenylsulfonamido)benzene; 4-(N, N-Dimethylamino)- 1-pentafluorophenylsulfonamidobenzene, hydrochloride; 2-Methoxy-5-pentafluorophenylsulfonamidopyridine; 2-Anilino-3-pentafluorophenylsulfonamidopyridine. Examples of the most preferred pharmaceutical compositions and compounds of the subject pharmaceutical methods include: 4-(N,N-Dimethylamino)- 1 -pentafluorophenylsulfonamidobenzene; 3-(N N-Dimethylamino)- 1 -pentafluorophenylsulfonamidobenzene; l,2-Ethylenedioxy-4-pentafluorophenylsulfonamidobenzene; 2-Hydroxy- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene; 2-Fluoro- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene; 2-Hydroxy- 1 -methoxy-4-ρentafluorophenylsulfonamidobenzene, sodium salt; 2-Hydroxy-l-methoxy-4-pentafluorophenylsulfonamidobenzene, potassium salt; 2-Fluoro-l-methoxy-4-pentafluorophenylsulfonamidobenzene, sodium salt; 2-Fluoro- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, potassium salt; 4-Methoxy- 1 -pentafluorophenylsulfonamidobenzene; 3-Hydroxy- 1 -pentafluorophenylsulfonamidobenzene; 4-Hydroxy- 1 -pentafluorophenylsulfonamidobenzene; l,2-Dimethyl-4-pentafluorophenylsulfonamidobenzene; 5-Pentafluorophenylsulfonamidoindole; 4-Ethoxy- 1 -pentafluorophenylsulfonamidobenzene; 3 -Methoxy- 1 -pentafluorophenylsulfonamidobenzene; 2 -Bromo- 1 -methoxy-4-pentafluoropheny 1 sulfonamidobenzene ; 2-Chloro- 1 -methoxy-4-pentafluoropheny lsulfonamidobenzene; 2-Bromo-3-hydroxy-4-methoxy- 1 -pentafluorophenylsulfonamidobenzene; 2-Bromo-4-methoxy-5-hydroxy- 1 -pentafluorophenylsulfonamidobenzene; l-Bromo-4-fluoro-5-methoxy-2-pentafluorophenylsulfonamidobenzene; 4-Chloro-l-pentafluorophenylsulfonamidobenzene; and 3 -Amino-4-methoxy- 1 -pentafluorophenylsulfonamidobenzene. The invention provides for certain novel compounds of general Formula I that possess one or more valuable biological activities such as a pharmacologic, toxicologic, metabolic, etc. Exemplary compounds of this embodiment of the invention include: 2-Fluoro- 1 -methoxy-4-pentafluorophenylsulfinamidobenzene; 4-Dimethylamino- 1 -pentafluorophenylsulfinamidobenzene; 4-Methyl-6-methoxy-2-pentafluorophenylsulfonamidopyrimidine; 4,6-Dimethoxy-2-pentafluorophenylsulfonamidopyrimidine; 2-Pentafluorophenylsulfonamidothiophene; 3-Pentafluorophenylsulfonamidothiophene; 3 -Pentafluoropheny lsulfonamidopyridine; 4-Pentafluorophenylsulfonamidopyridine; 4-(NN,-Dimethy lamino)- l-(N-ethylpentafluorophenylsulfonamido) benzene; 4-tør/-Butoxy- 1 -pentafluoropheny lsulfonamidobenzene; 3- rt-Butoxy- 1 -pentafluorophenylsulfonamidobenzene; 2-/ert-Butoxy- 1 -pentafluoropheny lsulfonamidobenzene; 4-Isopropoxy- 1 -pentafluorophenylsulfonamidobenzene; 3-Isopropoxy- 1 -pentafluorophenylsulfonamidobenzene; 2-Isopropoxy- 1 -pentafluorophenylsulfonamidobenzene; 2-Methoxy- 1 ,3-difluoro-5-pentafluorophenylsulfonamidobenzene; 1 -Hydroxy-2,3-methylenedioxy-5-pentafluorophenylsulfonamidobenzene; l-Hydroxy-2,3-ethylenedioxy-5-pentafluoropheny lsulfonamidobenzene; l-Hydroxy-2,3-carbodioxy-5-pentafluorophenylsulfonamidobenzene; l,3-Dihydroxy-2-ethoxy-5-pentafluorophenylsulfonamidobenzene; 1 -Pentafluoropheny Isulfonylindole; 1 -Pentafluorophenylsulfonyl(2,3-dihydro)indole; 1 -Pentafluorophenylsulfonyl( 1 ,2-dihydro)quinoline; l-Pentafluorophenylsulfonyl(l,2,3,4-tetrahydro)quinoline; 3,4-Difluoro- 1 -pentafluorophenylsulfonamidobenzene; 4-Trifluoromethoxy- 1 -pentafluorophenylsulfonamidobenzene; 2-Chloro-5-pentafluorophenylsulfonamidopyridine; 2-Hydroxy- 1 -methoxy-4-[Ν-5-hydroxypent- 1 -yl)pentafluorophenyl-sulfonamido]benzene; 4-( 1 , 1 -Dimethyl)ethoxy- 1 -pentafluorophenylsulfonamidobenzene; 1 -Bromo-3-hydroxy-4-methoxy- 1 -pentafluorophenylsulfonamidobenzene; 2-Bromo-4-methoxy-5-hydroxy- 1 -pentafluorophenylsulfonamidobenzene; l-Bromo-4-fluoro-5-methoxy-2-pentafluorophenylsulfonamidobenzene; 3 -Chloro- 1 -pentafluoropheny lsulfonamidobenzene; 4-Chloro- 1 -pentafluorophenylsulfonamidobenzene; 3 -Nitro- 1 -pentafluoropheny lsulfonamidobenzene ; 4-Methoxy- 1 -pentafluorophenylsulfonamido-3-(trifluoromethyl)benzene; 4-Methoxy- 1 -[N-(2-propenyl)pentafluoropheny lsulfonamidojbenzene; l-(N-(3-Butenyl)pentafluorophenylsulfonamido)-4-methoxybenzene; 4-Methoxy- 1 -(N-(4-pentenyl)pentafluorophenylsulfonamido)benzene; l-[N-(2,3-Dihydroxypropyl)pentafluorophenylsulfonamido]-4-methoxy-benzene; l-(N-(3,4-Dihydroxybutyl)pentafluorophenylsulfonamido)-4-methoxybenzene; l-(N-(4,5-Dihydroxypentyl)pentafluorophenylsulfonamido)-4-methoxybenzene; l-(N-(4-hydroxybutyl)pentafluorophenylsulfonamido)-4-methoxybenzene; 4-Methoxy-l-(N-(5-hydroxypentyl)pentafluorophenylsulfonamido)-benzene; 3 -Amino-4-methoxy- 1 -pentafluoropheny lsulfonamidobenzene; 4-Butoxy- 1 -pentafluoropheny lsulfonamidobenzene; l-Pentafluorophenylsulfonamido-4-phenoxy benzene; 4-Benzyloxy- 1 -pentafluoropheny lsulfonamidobenzene ; 4-Methylmercapto- 1 -pentafluoropheny lsulfonamidobenzene; 2-Methoxy- 1 -pentafluorophenylsulfonamidobenzene; 4-Allyloxy- 1 -pentafluorophenylsulfonamidobenzene; l-Pentafluorophenylsulfonamido-4-propoxybenzene; 4-( 1 -MethyI)ethoxy- 1 -pentafluorophenylsulfonamidobenzene; l,2-Methylenedioxy-4-pentafluorophenylsulfonamidobenzene; l,2-Dimethoxy-4-pentafluorophenylsulfonamidobenzene; 4-(NN-Diethylamino)- 1 -pentafluorophenylsulfonamidobenzene; 4- Amino- 1 -pentafluorophenylsulfonamidobenzene; Pentafluorophenylsulfonamidobenzene; 5-Pentafluorophenylsulfonamidoindazole; 4-(N,N-Dimemylamino)-l-(N-methylpentafluorophenylsulfonamido)-benzene; l,2-Dihydroxy-4-pentafluorophenylsulfonamidobenzene; 3,5-Dimethoxy-l-pentafluorophenylsulfonamidobenzene; 3 -Ethoxy- 1 -pentafluoropheny lsulfonamidobenzene; 7-Hydroxy-2-pentafluorophenylsulfonamidonaphthalene; 3 -Phenoxy- 1 -pentafluorophenylsulfonamidobenzene; 4-( 1 -Morpholino)- 1 -pentafluoropheny lsulfonamidobenzene; 5-Pentafluorophenylsulfonamido- 1 ,2,3-trimethoxy benzene; 2-Hydroxy- 1 ,3-methoxy-5-pentafluorophenylsulfonamidobenzene; l,2-Dihydroxy-3-methoxy-5-pentafluorophenylsulfonamidobenzene; 5 -Pentafluoropheny Isulfonamido- 1 ,2,3-trihydroxybenzene; 4-Cyclopropoxy- 1 -pentafiuorophenylsulfonamidobenzene; 3-Fluoro-4-cyclopropoxy- 1 -pentafluorophenylsulfonamidobenzene; 6-Pentafluorophenylsulfonamidoquinoline; 2,3-Dihydro-5-pentafluorophenylsulfonamidoindole; 5-Pentafluorophenylsulfonamidobenzo[a]thiophene; 5-Pentafluorophenylsulfonamidobenzo[a]furan; 3-Hydroxy-4-(l-propenyl)-l-pentafluorophenylsulfonamidobenzene; 3-Hydroxy-5-methoxy- 1 -pentafluorophenylsulfonamidobenzene; 3,5-Dihydroxy-l-pentafluorophenylsulfonamidobenzene; 2-Fluoro- 1 -methoxy-4-(N-methylpentafluorophenylsulfonamido)benzene; 4-(N,N-Dimethylamino)- 1 -pentafluorophenylsulfonamidobenzene, hydrochloride; and, 2-Analino-3-pentafluorophenylsulfonamidopyridine. Preferred compounds of this embodiment of the invention have specific pharmacological properties. Examples of the most preferred compounds of this embodiment of the invention include: 4-(N,N-Dimethy lamino)- 1 -pentafluorophenylsulfonamidobenzene; 3 -(N N-Dimethylamino)- 1 -pentafluorophenylsulfonamidobenzene; l,2-Ethylenedioxy-4-pentafluorophenylsulfonamidobenzene; 2-Hydroxy- 1 -methoxy-4-pentafluoropheny lsulfonamidobenzene; 2-Fluoro- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene; 2-Hydroxy-l-methoxy-4-pentafluorophenylsulfonamidobenzene, sodium salt; 2-Hydroxy- 1 -methoxy-4-pentafluoropheny lsulfonamidobenzene, potassium salt; 2-Fluoro-l-methoxy-4-pentafluorophenylsulfonamidobenzene, sodium salt; 2 -Fluoro- l-methoxy-4-pentafluoropheny lsulfonamidobenzene, potassium salt; 4-Methoxy- 1 -pentafluoropheny lsulfonamidobenzene; 3-Hydroxy- 1 -pentafluorophenylsulfonamidobenzene; 4-Hydroxy- 1 -pentafluorophenylsulfonamidobenzene; l,2-Dimethyl-4-pentafluorophenylsulfonamidobenzene; 5-Pentafluorophenylsulfonamidoindole; 4-Ethoxy- 1 -pentafluorophenylsulfonamidobenzene; -Methoxy- 1 -pentafluoropheny lsulfonamidobenzene; 2-Bromo- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene; 2-Chloro- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene; -Bromo-3-hydroxy-4-methoxy-l-pentafluorophenylsulfonamidobenzene; -Bromo-4-methoxy-5-hydroxy- 1 -pentafluorophenylsulfonamidobenzene; l-Bromo-4-fluoro-5-methoxy-2-pentafluorophenylsulfonamidobenzene; -Chloro- 1 -pentafluorophenylsulfonamidobenzene; and -Amino-4-methoxy- 1 -pentafluorophenylsulfonamidobenzene. SYNTHESIS Scheme I Syntheses of pentafluorophenylsuifonamides, sulfonic esters, sulfinamides, and sulfϊnic esters Sulfonamide Sulfinamide Scheme II Alternative synthesis of N, N-disubstituted pentafluorophenylsuifonamides. Scheme LTI Syntheses of phenols x=l-3 The invention provides methods of making the subject compounds and compositions. In one general embodiment, the methods involve combining pentafluorophenylsulfonyl chloride with an amine having the general formula R'R 2 NH under conditions whereby the pentafluorophenylsulfonyl chloride and amine react to form the desired compound, and isolating the compound. Compounds with the generic structure 1 or 3 (Scheme I) may be prepared by reacting the appropriate starting amine in a solvent such as tetrahydrofuran (THF), dimethylformamide (DMF), ether, toluene or benzene in the presence of a base such as pyridine, -dimethylaminopyridine, triethylamine, sodium carbonate or potassium carbonate and pentafluorophenylsulfonyl chloride or pentafluorophenylsulfinyl chloride, respectively. Pyridine itself may also be used as the solvent. Preferred solvents are pyridine and DMF and preferred bases are pyridine, triethylamine, and potassium carbonate. This reaction can be carried out at a temperature range of 0 °C to 100 °C, conveniently at ambient temperature. Compounds of the generic structure 1 can also be obtained by treating the starting sulfonamide (Scheme II) with a base such as LDA, NaH, dimsyl salt, alkyl lithium, potassium carbonate, under an inert atmosphere such as argon or nitrogen, in a solvent such as benzene, toluene, DMF or THF with an alkylating group containing a leaving group such a Cl, Br, I, MsO-, TsO-, TFAO-, represented by E in Scheme II. A preferred solvent for this reaction is THF and the preferred base is lithium bis(trimethylsilyl)amide. This reaction can be carried out at a temperature range of 0 °C to 100 °C, conveniently at ambient temperature. Sulfonic esters (2) and sulfinic esters (4) may be prepared by reacting the appropriate starting phenol in a solvent such as THF, DMF, toluene or benzene in the presence of a base such as pyridine, triethylamine, sodium carbonate, potassium carbonate or 4- dimethylaminopyridine with pentafluorophenylsulfonyl chloride or pentafluorophenylsulfinyl chloride, respectively. Pyridine itself may also be used as the solvent. Preferred solvents are pyridine and DMF and preferred bases are sodium carbonate and potassium carbonate. This reaction can be carried out at a temperature range of 0 °C to 100 °C, conveniently at ambient temperature. Compounds of the general structure 5, in which Ar is an aromatic group and x is from one to three, can be obtained from the corresponding methyl ethers (Scheme III) by reaction with boron tribromide in a solvent of low polarity such as hexanes or CH 2 C1 2 under an inert atmosphere at a temperature ranging from -45° to 30 °C. In a preferred embodiment, the reaction is carried out in CH 2 C1 2 at about 30 °C. Occasionally, the substrates for the transformations shown in Schemes I-III may contain functional groups (for example, amino, hydroxy or carboxy) which are not immediately compatible with the conditions of the given reaction. In such cases, these groups may be protected with a suitable protective group, and this protective group removed subsequent to the transformation to give the original functionality using well know procedures such as those illustrated in T.W. Greene and P.G. M. Wuts, Protective Groups in Organic Synthesis, Second Edition, John Wiley & Sons, Inc., 1991. The compounds used as initial starting materials in this invention may be purchased from commercial sources or alternatively are readily synthesized by standard procedures which are well know to those of ordinary skill in the art. Some of the compounds of formula I may exist as stereoisomers, and the invention includes all active stereoisomeric forms of these compounds. In the case of optically active isomers, such compounds may be obtained from corresponding optically active precursors using the procedures described above or by resolving racemic mixtures. The resolution may be carried out using various techniques such as chromatography, repeated recrystallization of derived asymmetric salts, or derivatization, which techniques are well known to those of ordinary skill in the art. The compounds of formula I which are acidic or basic in nature can form a wide variety of salts with various inorganic and organic bases or acids, respectively. These salts must be pharmacologically acceptable for administration to mammals. Salts of the acidic compounds of this invention are readily prepared by treating the acid compound with an appropriate molar quantity of the chosen inorganic or organic base in an aqueous or suitable organic solvent and then evaporating the solvent to obtain the salt. Acid addition salts of the basic compounds of this invention can be obtained similarly by treatment with the desired inorganic or organic acid and subsequent solvent evaporation and isolation. The compounds of the invention may be labeled in a variety of ways. For example, the compounds may be provided as radioactive isotopes; for example, tritium and the ,4 C-isotopes. Similarly, the compounds may be advantageously joined, covalently or noncovalently, to a wide variety of joined compounds which may provide pro-drugs or function as carriers, labels, adjuvents, coactivators, stabilizers, etc. Hence, compounds having the requisite structural limitations encompass such compounds joined directly or indirectly (e.g. through a linker molecule), to such joined compounds. ANALYSIS The subject compositions were demonstrated to have pharmacological activity in in vitro and in vivo assays, e.g. are capable of specifically modulating a cellular physiology to reduce an associated pathology or provide or enhance a prophylaxis. Preferred compounds are capable of specifically regulating LDL receptor gene expression. Compounds may be evaluated in vitro for their ability to increase LDL receptor expression using western-blot analysis, for example, as described in Tarn et al. (1991) J. Biol. Chem. 266, 16764. Established animal models to evaluate hypocholesterolemic effects of compounds are known in the art. For example, compounds disclosed herein are shown to lower cholesterol levels in hamsters fed a high-cholesterol diet, using a protocol similar to that described in Spady et al. (1988) J. Clin. Invest. 81, 300; Evans et al. (1994) J. Lipid Res. 35, 1634; Lin et al (1995) J. Med. Chem. 38, 277. FORMULATION AND ADMINISTRATION The invention provides methods of using the subject compounds and compositions to treat disease or provide medicinal prophylaxis, to upregulate LDL receptor gene expression in a cell, to reduce blood cholesterol concentration in a host, etc. These methods generally involve contacting the cell with or administering to the host an effective amount of the subject compounds or pharmaceutically acceptable compositions. The compositions and compounds of the invention and the pharmaceutically acceptable salts thereof can be administered in any effective way such as via oral, parenteral or topical routes. Generally, the compounds are administered in dosages ranging from about 2 mg up to about 2,000 mg per day, although variations will necessarily occur depending on the disease target, the patient, and the route of administration. Preferred dosages are administered orally in the range of about 0.05 mg/kg to about 20 mg/kg, more preferably in the range of about 0.05 mg/kg to about 2 mg/kg, most preferably in the range of about 0.05 mg/kg to about 0.2 mg per kg of body weight per day. In one embodiment, the invention provides the subject compounds combined with a pharmaceutically acceptable excipient such as sterile saline or other medium, water, gelatin, an oil, etc. to form pharmaceutically acceptable compositions. The compositions and/or compounds may be administered alone or in combination with any convenient carrier, diluent, etc. and such administration may be provided in single or multiple dosages. Useful carriers include solid, semi-solid or liquid media including water and non-toxic organic solvents. In another embodiment, the invention provides the subject compounds in the form of a pro-drug, which can be metabolically converted to the subject compound by the recipient host. A wide variety of pro-drug formulations are known in the art. The compositions may be provided in any convenient form including tablets, capsules, lozenges, troches, hard candies, powders, sprays, creams, suppositories, etc. As such the compositions, in pharmaceutically acceptable dosage units or in bulk, may be incorporated into a wide variety of containers. For example, dosage units may be included in a variety of containers including capsules, pills, etc. The compositions may be advantageously combined and/or used in combination with other hypocholesterolemic and/or hypolipemic therapeutic or prophylactic agents, different from the subject compounds. In many instances, administration in conjunction with the subject compositions enhances the efficacy of such agents. Exemplary hypocholesterolemic and/or hypolipemic agents include: bile acid sequestrants such as quaternary amines (e.g. cholestyramine and colestipol); nicotinic acid and its derivatives; HMG-CoA reductase inhibitors such as mevastatin, pravastatin, and simvastatin; gemfibrozil and other fibric acids, such as gemfibrozil, clofibrate, fenofibrate, benzafibrate and cipofibrate; probucol; raloxifene and its derivatives; and mixtures thereof. The compounds and compositions also find use in a variety of in vitro and in vivo assays, including diagnostic assays. For example, various allotypic LDL receptor gene expression processes may be distinguished in sensitivity assays with the subject compounds and compositions, or panels thereof. In certain assays and in in vivo distribution studies, it is desirable to used labeled versions of the subject compounds and compositions, e.g. radioligand displacement assays. Accordingly, the invention provides the subject compounds and compositions comprising a detectable label, which may be spectroscopic (e.g. fluorescent), radioactive, etc. The following examples are offered by way of illustration and not by way of limitation. EXAMPLES ! H NMR spectra were recorded on a Varian Gemini 400MHz NMR spectrometer. Significant peaks are tabulated in the order: multiplicity (s, singlet; d, doublet; t, triplet; q, quartet; m, multiplet), coupling constant(s) in Hertz, number of protons. Electron Ionization (EI) mass spectra were recorded on a Hewlett Packard 5989A mass spectrometer. Fast Atom Bombardment (FAB) mass spectroscopy was carried out in a VG analytical ZAB 2-SE high field mass spectrometer. Mass spectroscopy results are reported as the ratio of mass over charge, and the relative abundance of the ion is reported in parentheses. Example 1 4-(N,N-Dimethylamino)- 1 -pentafluorophenylsulfonamidobenzene. To N,N-dimethyl-l,4-phenyldiamine dihydrochloride (3g, 14.6mmol) suspended in pyridine (50mL) at 0 °C under argon was added dropwise pentafluorobenzenesulfonyl chloride (2.38mL, 16mmol). The reaction mixture was stirred for 30 min at 0 °C and allowed to warm to ambient temperature. The reaction mixture was stirred at room temperature for 3h. The volume of the mixture was then reduced to 10 mL under reduced pressure. The mixture was diluted with ethyl acetate and the reaction quenched with water. The layers were separated and the aqueous layer extracted twice with ethyl acetate. The organic layers were combined and washed with brine and dried with MgSO 4 . The solvent was evaporated and the residue purified by chromatography on silica, eluting with CH 2 C1 2 . The title product was obtained as a white solid in 63% yield (3.4g). Η ΝMR (CDC1 3 ): 7.01(d, J=8.9Hz, 2H), 6.77(s, IH), 6.59(d, J=8.3Hz, 2H), 2.92ppm(s, 6H). FAB m/z (relative abundance): 367(100%, M+H + ), 135(30%), 121(25%). Anal, calcd. for C, 4 H n F 5 Ν 2 O 2 S: C 45.95, H 3.03, N 7.65. Found C 45.83, H 2.99, N 7.62 Example 2 3-(N,N-Dimethylamino)-l-pentafluorophenylsulfonamidobenzene. 'H ΝMR (CDC1 3 ): 7.12(t, J=8Hz, IH), 7.05(s, IH), 6.57(s, IH) 6.53(d, J=8Hz, IH), 6.40(d, J=8Hz, IH), 2.94ppm (s, 6H). FAB m/z: 366 (100%, M + ). The compound was prepared by a protocol similar to that of example 1 by replacing NN-dimethyl-l,4-phenyldiamine dihydrochloride with 3-(N y N-dimethylamino)aniline. Example 3 l,2-Ethylenedioxy-4-pentafluoropheny lsulfonamidobenzene. ! H ΝMR (CDC1 3 ): 6.97(s, IH), 6.76(d, J=8.6Hz, IH), 6.72(d, J=2.6Hz, IH), 6.62(dd, J=8.6, 2.6Hz, IH), 4.21ppm (s, 4H). FAB m/z: 381(100%, M+H + ). Anal calcd. for C 14 H 8 F 5 ΝO 4 S: C 44.09, H 2.12, N 3.68, S 8.39. Found: C 43.83, H 2.19, N 3.62, S 8.20. The compound was prepared by a protocol similar to that of example 1 by replacing N,N-dimethyl-l,4-phenyldiamine dihydrochloride with 3,4-ethylenedioxyaniline. Example 4 l,2-Methylenedioxy-4-pentafluorophenylsulfonamidobenzene. l H NMR (CDC1 3 ): 6.85(s, IH), 6.78 (s, IH), 6.70(d,J=8Hz, IH), 6.57(d, J=8Hz, IH), 5.97ppm(s, 2H). The compound was prepared by a protocol similar to that of example 1 by replacing N,N-dimethyl-l,4-phenyldiamine dihydrochloride with 3,4-methylenedioxyaniline. Example 5 l,2-Dimethoxy-4-pentafluorophenylsulfonamidobenzene. l H ΝMR (CDC1 3 ): 6.98(s, IH), 6.85(d, IH), 6.74(d, IH), 6.60(dd, IH), 3.85(s, 3H), 3.83ppm (s, 3H). EI, m/z: 383(50, M + ), 152(100). The compound was prepared by a protocol similar to that of example 1 by replacing N,N-dimethyl-l,4-phenyldiamine dihydrochloride with 3,4-dimethoxyaniline. Example 6 2-Hydroxy-l-methoxy-4-pentafluorophenylsulfonamidobenzene. 'H NMR (CDC1 3 ): 6.93(s, IH), 6.7-6.8(m, 3H), 5.68(bs, IH), 3.85ppm(s, 3H). EI, m/z: 333(20, M + ), 138(100). mp 118-120 °C. The compound was prepared by a protocol similar to that of example 1 by replacing N,N-dimethyl-l,4-phenyldiamine dihydrochloride with 3-hydroxy-4-methoxyaniline. Example 7 3 -Fluoro-4-methoxy- 1 -pentafluorosulfonamidobenzene. 'H ΝMR (DMSO) 11.15 (broad s, IH), 7.13 (t, J=9Hz, IH), 7.02 (dd, J=9.5 2.5 Hz, IH), 6.94ppm (dd, J=8.8 1.5Hz, IH), 3.79ppm (s, 3H). EI, m z: 371 (20, M + ), 140 (100). Anal, calcd. for C 13 H 7 HF 6 Ν,O 3 S,: C 42.06, H 1.90, N 3.77, S 8.64. Found: C 42.19, H 1.83, N 3.70, S 8.60. Mp 118-119°C. The compound was prepared by a protocol similar to that of example 1 by replacing N,N-dimethyl-l,4-phenyldiamine dihydrochloride with 3-fluoro- -anisidine. Example 8 4-Methoxy-l -pentafluoropheny lsulfonamidobenzene. 'H NMR (CDC1 3 ): 6.99 (s, IH), 6.96(d, J=4Hz, 2H), 6.88 (d, J=4Hz, 2H), 3.83ppm(s, 3H). EI, m/z: 353 (60, M + ), 122 (100). M.p. 102-103 °C. The compound was prepared by a protocol similar to that of example 1 by replacing N,N-dimethyl-l,4-phenyldiamine dihydrochloride with 4-methoxyaniline. Example 9 3-Hydroxy-l-pentafluorophenylsulfonamidobenzene. l H ΝMR (CD 3 OD): 7.15(t, J=8.1Hz, IH), 6.67(t, J=2.2Hz, IH) 6.60(dd, J=1.3Hz, 7.8Hz, IH), 6.52ppm (dd, J=2.4Hz 8.3Hz, IH). EI, m/z: 339 (80, M + ), 256 (50), 81 (100). The compound was prepared by a protocol similar to that of example 1 by replacing N,N-dimethyl-l,4-phenyldiamine dihydrochloride with 3-hydroxyaniline. Example 10 4-Hydroxy-l-pentafluorosulfonamidobenzene. Η NMR (CD 3 OD): 6.95(d, J=8.9Hz, 2H), 6.65ppm (d, J=8.9Hz, 2H). EI, m/z: 339 (30, M + ). The compound was prepared by a protocol similar to that of example 1 by replacing N,N-dimethyl-l,4-phenyldiamine dihydrochloride with 4-hydroxyaniline. Example 11 l,2-Dimethyl-4-pentafluorophenylsulfonamidobenzene. l H ΝMR (CDC1 3 ): 7.03(d, J=7.9Hz, IH), 6.92(s, IH), 6.85-6.82(m, 2H), 2.18(s, 3H), 2.16ppm(s, 3H). The compound was prepared by a protocol similar to that of example 1 by replacing N,N-dimethyl-l,4-phenyldiamine dihydrochloride with 3,4-dimethylaniline. Example 12 4-(N ) N-Diethylamino)-l-pentafluorophenylsulfonamidobenzene. Η ΝMR (CDC1 3 ): 6.93(d, J=8.8Hz, 2H), 6.78(s, 1), 6.45(d, J=8.7Hz, 2H), 3.25(dd, J=7.0Hz, 7.3Hz,4H), l.lOppm (t, J=7.2Hz, 6H). The compound was prepared by a protocol similar to that of example 1 by replacing N, N-dimethy 1-1,4-phenyldiamine dihydrochloride with 4-(NN-dieώylamino)aniline. Example 13 4-Amino-l-pentafluorophenylsulfonamidobenzene. Η ΝMR (CDC1 3 ): 6.82(d, J=8.7Hz, 2H), 6.49ppm(d, J=8.7Hz, 2H). EI, m/z: 338(7, M + ), 107(100), 80(40). The compound was prepared by a protocol similar to that of example 1 by replacing N, N-dimethy 1-1 ,4-phenyldiamine dihydrochloride with 1,4-diaminobenzene. Example 14 Pentafluorophenylsulfonamidobenzene. 'H NMR (CDC1 3 ): 7.30(d, J=8Hz, 2H), 7.13-7.2(m, 3H), 7.0ppm(s, IH). EI, m/z: 323(90, M + ), 92(100). The compound was prepared by a protocol similar to that of example 1 by replacing N, N-dimethy 1-1,4-phenyldiamine dihydrochloride with aniline. Example 15 H 5-Pentafluorophenylsulfonamidoindazole. Η ΝMR (CD 3 OD): 7.98(s, IH), 7.69(s, IH), 7.47(d, J=8.3Hz, IH), 7.23ppm(d, J=8.3Hz, IH). EI m z: 364(50, M+H + ), 133(100). The compound was prepared by a protocol similar to that of example 1 by replacing N, N-dimethy 1-1,4-phenyldiamine dihydrochloride with 5-aminoindazole. Example 16 5-Pentafluorophenylsulfonamidoindole. Η NMR (CDC1 3 ): 8.2(s, IH), 7.43(s, IH), 7.3(d, J=8 Hz, IH), 7.22(s, IH)), 6.98 (d, J=8 Hz, IH), 6.92ppm (s, IH), 6.50ppm(s, IH). EI m z: 362(M + ), 131(100). The compound was prepared by a protocol similar to that of example 1 by replacing N, N-dimethy 1- 1 ,4-phenyldiamine dihydrochloride with 5-aminoindole. Example 17 4-(N, N-Dimethylamino)- 1 -(N-methylpentafluorophenylsulfonamido)benzene . 4-(N N-Dimethylamino)- 1 -(pentafluoropheny lsulfonamido)benzene (lOOmg, 0.273mmol) was dissolved in dry THF (2.5mL) and to the system was added under Ν 2 at room temperature a IM solution of lithium 6w(trimethylsilyl)arnide (0.274mL). The reaction mixture was stirred for 10 min followed by addition of Mel (65mg, 0.028mL). The reaction mixture was stirred overnight, the solvent was evaporated under reduced pressure and the crude product purified by HPLC using silica as the stationary phase and eluting with 20%EtOAc/Hex (v/v) to afford the product as a white solid in 60% yield (62mg). EI m/z: 380(35, M + ), 149(100). 'H NMR (CD 3 OD) 7.05(d, J=8Hz, 2H), 6.68(d, J=8Hz, 2H), 3.33(s, 3H) 2.93(s, 6H). Anal, calcd. for C 15 H 13 F 5 SO 2 N 2 : C 47.37, H 3.45, N 7.37. Found: C 47.37, H 3.49, N 7.32. Example 18 1 ,2 -Dihy droxy-4-pentafluorophenylsulfonamidobenzene . 1 -Hydroxy-2-methoxy-4-pentafluorophenylsulfonamidobenzene (250mg, 0.678mmol) was suspended in dry CH 2 C1 2 (5mL) at 0 °C under nitrogen. To the mixture was added BBr 3 as a IM solution in CH 2 C1 2 (0.746mmol, 1.1 eq.). The mixture was warmed to ambient temperature and stirred overnight. The reaction mixture was poured over ice (75mL) and extracted 3 times with 30 mL portions of CH 2 C1 2 . The organic layer was dried with MgSO 4 and the solvent was evaporated. The crude product was purified by chromatography over silica eluting wim 30% (v/v) EtO Ac/Hex to afford the product as a white solid in 41% yield (98mg). Η NMR (DMSO): 10.63(s, IH), 9.15(s, IH), 8.91(s, IH), 6.61(d, J=9Hz, IH), 6.58(d, J=3Hz, IH), 6.39ppm(dd, J= 9Hz 3Hz, IH). Example 1 4-Ethoxy-l-pentafluorobenzenesulfonamidobenzene. To a stirred solution of/7-phenetidine (0. lOOg, 0.729mmol) in dimethylformamide (3.65 mL) at 25 °C was added pentafluorobenzene sulfonyl chloride (0.135mL, 0.91 lmmol), followed by sodium carbonate (0.116g, 1.09mmol), and the reaction mixture was stirred for 18 hours. The reaction mixture was diluted with ethyl acetate (50mL) and washed with 20% ammonium chloride (2 x 20mL) and saturated sodium chloride (2 x 20mL). The organic layer was dried (sodium sulfite), and the ethyl acetate was removed under reduced pressure to yield a reddish-brown oil. Column chromatography (3:1 ethyl acetate/hexane) yielded the title compound (0.222g, 83%). 'H NMR (CDC1 3 ) 7.08 (d, J= 9Hz, 2H), 7.04 (s, IH), 6.80 (d, J= 9Hz, 2H), 3.96 (q, J=7Hz, 2H), 1.37 ppm (t, J=7Hz, 2H). IR (neat) 3000-3600, 1750 cm-'. EI m/z : 367(M + ), 154, 136. The compounds of Examples 20 through 26 were prepared by a protocol similar to that of Example 19 by replacing 77-phenetidine with the appropriate amine. Example 20 3,5-Dimethoxy-l-pentafluorobenzenesuIfonamidobenzene . The compound was prepared by a protocol similar to that of Example 19 by replacing /?-phenetidine with 3,5-dimethoxyaniline. 1H NMR (CDC1 3 ) 6.91(s, IH), 6.32(s, 2H), 6.25(s, IH), 3.72ppm(s, 6H). Example 21 3 -Ethoxy- 1-pentafluorobenzenesulfonamidobenzene . The compound was prepared by a protocol similar to that of Example 19 by replacing 7-phenetidine with 3-ethoxyaniline. 'H NMR (CDC1 3 ) 7.35 (t, J= 8Hz, IH), 7.21( s, IH), 6.92( s, IH), 6.86(d, J=8Hz, IH), 6.83(d, J=8Hz, IH), 4.15( q, J=6Hz, 2H), 1.56ppm ( t, J=6Hz, 3H). Example 22 7-Hydroxy-2-pentafluorobenzenesulfonamidonaphthalene. The compound was prepared by a protocol similar to that of Example 19 by replacing -phenetidine with 2-amino-7-hydroxynaphthalene. Η NMR (CDC1 3 ) 8.15 ( t, J= 8Hz, IH), 7.55( d, J=8Hz, IH), 7.44 (s, IH), 7.42 (d, J=8Hz, IH), 7.40 (s, IH), 6.88ppm (q, J=8Hz, IH). Example 23 3-Phenoxy-l-pentafluorobenzenesulfonamidobenzene. The compound was prepared by a protocol similar to that of Example 19 by replacing j-phenetidine with 3-phenoxyaniline. 'H NMR (CDC1 3 ) 7.34 ( t, J= 8Hz, 2H), 7.26 ( t, J=8Hz, IH), 7.16 ( t, J=8Hz, IH), 6.94 (d, J=8Hz, 2H), 6.86 ( d, J=8Hz, IH), 6.82 ( d, J=8Hz, IH), 6.74 (s, IH ). Example 24 3-Methoxy-l-pentafluorobenzenesulfonamidobenzene. The compound was prepared by a protocol similar to that of Example 19 by replacing /7-phenetidine with 3 -methoxy aniline. 'H NMR (CDC1 3 ) 7.20 (d, J= 8Hz, IH, ), 6.95 (s, IH), 6.78 ( d, J=8Hz, IH,), 6.70 ( t, J=8Hz, IH), 3.79 ppm (s, IH). Example 25 4-(l-Mθφholino)-l-pentafluorobenzenesulfonamidobenzene. The compound was prepared by a protocol similar to that of Example 19 by replacing /?-phenetidine with 4-(l-moφholino)aniline. Η NMR (CDC1 3 ) 7.09 (d, J= 8Hz, 2H), 6.85 (d, J=8Hz, 2H), 3.85 (t, J=8Hz, 4H), 3.15ppm (t, J=8Hz, 4H). Example 26 5-Pentafluorobenzenesulfonamido-l,2,3-trimethoxybenzene. The compound was prepared by a protocol similar to that of Example 19 by replacing >-phenetidine with 3,4,5-trimethoxyaniline. Η NMR (CDC1 3 ) 8.14 (s, IH), 6.46 (s, 2H), 3.69 (s, 6H), 3.59 (s, 3H). Example 27 l,3-Dimethoxy-2-hydroxy-5-pentafluorobenzenesulfonamidobenzene . l,2-Dihydroxy-3-methoxy-5-pentafluorobenzenesulfonamidobenzene. 5-Pentafluorobenzenesulfonamido- 1 ,2,3-trihydroxybenzene. l,2,3-Methoxy-5-pentafluorobenzenesulfonamidobenzene (269mg, 0.65mmol) was suspended in dry CH 2 C1 2 (5mL) at 0 °C under nitrogen. To the mixture was added BBr 3 as a IM solution in CH 2 C1 2 (3.26mmol, 5eq.). The mixture was warmed to ambient temperature and stirred overnight. The reaction mixture was poured over ice (75mL) and extracted 3 times with 30 mL portions of CH C1 2 . The organic layer was dried with MgSO 4 , evaporated, and the residue was subjected to chromatography over silica eluting with 30% (v/v) EtO Ac/Hex to afford the three products. The compounds of Examples 28 and 29 were prepared in a manner similar to that described above beginning with the product of Example 20 and treating it with BBr,. l,3-Dimethoxy-2-hydroxy-5-pentafluorobenzenesulfonamidobenzene *H NMR (CDCI 3 ) 10.85 (s, IH), 8.31 (s, IH), 6.41 (s, 2H), 3.66 ppm (s, 6H). l,2-Dihydroxy-3-methoxy-5-pentafluorobenzenesulfonamidobenzene. 'H NMR (CDC1 3 ) 10.73 (s, IH), 8.31 (s, IH), 6.27 (s, IH), 6.26 (s, IH), 3.66 ppm (s, 3H). 5-Pentafluorobenzenesulfonamido-l,2,3-trihydroxybenzene. 1 H NMR (CDC1 3 ) 11.0 (s, IH), 9.03 (s, 2H), 8.06 (s, IH), 6.13 ppm (s, 2H). Example 28 3-Hydroxy-5-methoxy-l-pentafluorobenzenesulfonamidobenzene. Η NMR (CDC1 3 ) 11.2 (s, IH), 9.63 (s, IH), 6.23 (s, IH), 6.21 (s, IH), 6.08 (s, IH), 3.63 (s, 3H). Example 29 3,5-Dihydroxy-l-pentafluorobenzenesulfonamidobenzene. 'H NMR (CDC1 3 ) 7.15 (s, IH), 6.25 (s, 2H), 6.15 (s, IH), 5.31 (s, 2H). Example 30 2-Fluoro-l-methoxy-4-(N-methylpentafluorophenylsulfonamido)benzene. Prepared using a procedure similar to that of Example 18 replacing 4-(N,N-dime ylamino)-l-pentafluorophenylsulfonamidobenzene with the appropriate non-substituted sulfonamide (product of Example 7). 'H ΝMR (CDC1 3 ): 6.97-6.94(m, 2H), 6.89(t, J=9Hz, IH), 3.87(s, 3H), 3.35ppm (t, J=lHz). EI m/z: 385(20, M + ), 154(100). Anal, calcd. for C, 4 H 9 F 6 ΝO 3 : C 43.64, H 2.35, N 3.64. Found C 43.55, H 2.38, N 3.65. Example 31 2-Bromo-l-methoxy-4-pentafluorophenylsulfonamidobenzene. Η NMR (CDC1 3 ): 7.35(d, J=3Hz, IH), 7.15(dd, J=9Hz, 3Hz, IH), 6.97 (s, IH), 6.81(d, J=9Hz, IH), 3.88 ppm (s, 3H). EI m/z: 433(35, M + ), 202(100). The compound was prepared by a protocol similar to that of example 1 by replacing N,N-dimethyl-l,4-phenyldiamine dihydrochloride with 3-bromo-4-methoxy aniline. Example 32 2-Chloro-l-methoxy-4-pentafluorophenylsulfonamidobenzene. 'H NMR (CDC1 3 ): 7.19(d, J=3Hz, IH), 7.08(dd, J=9Hz, 3Hz, IH), 7.01 (s, IH), 6.84(d, J=9Hz, IH), 3.85 ppm (s, 3H). EI m/z(rel. abundance): 387(10, M + ), 156(100). The compound was prepared by a protocol similar to that of example 1 by replacing N,N-dimethyl-l,4-phenyldiamine dihydrochloride with 3 -chloro-4-methoxy aniline. Exampl 33 4-(N, N-Dimethylamino)- 1 -pentafluoropheny lsulfonamidobenzene hydrochloride. 4-(N,N-Dimemylamino)-l-pentafluorophenylsulfonamidobenzene (2g, 5.5mmol) was dissolved in 15mL of diethyl ether at ambient temperature under nitrogen. Gaseous HCl was bubbled into the reaction mixture for 5 min. The mixture was filtered and the resulting solid washed twice with 15mL portions of ice cold diethyl ether to afford the product as a white solid (1.89g, 86% yield). »H ΝMR (CD 3 OD): 7.62(dd, J=9.0Hz, 1.6Hz, 2H), 7.44(dd, J=9.0Hz, 1.6Hz, 2H), 3.28ppm(s, 6H). FAB m/z: 367(100%, M+H + ), 135(90%), 121(45%). Anal, calcd. for C 14 H 13 ClF 5 Ν 2 O 2 S: C 41.79, H 3.01, N 6.97, S 7.95. Found C 41.71, H 3.05, N 7.01, S 7.96. Example 34 3,4-Difluoro-l-pentafluorobenzenesulfonamidobenzene. The compound was prepared in a manner similar to that of example 1 by replacing N, N-dimethy 1-1 ,4-phenyldiamine dihydrochloride with 3,4-difluoroaniline. 1H ΝMR (CDC1 3 ) 7.13 (m, 3H), 6.91ppm (m, IH). EI, m/z (relative abundance) : 359 (20), 128 (100). Anal, calcd. for C13H4F7Ν1O2S1 : C 40.12, H 1.12, N 3.90. Found: C 40.23, H 1.17, N 3.89. Example 35 4-Trifluoromethoxy-l-pentafluorobenzenesulfonamidobenzene. The compound was prepared in a manner similar to that of example 1 by replacing N N-dimethyl- 1 ,4-phenyldiamine dihydrochloride with 4-(trifluoromethoxy )aniline. ' H ΝMR (CDC1 3 ) 7.18ppm (m, 4H). EI, m/z (relative abundance) : 407 (20), 176 (100). Anal. calcd. for C13H5F8Ν1O3S1 : C 38.34, H 1.24, N 3.44. Found: C 38.33, H 1.30, N 3.43. Example 36 2-Chloro-5-pentafluorophenylsulfonamidopyridine. The compound was prepared in a manner similar to that of example 1 by replacing N, N-dimethy 1-1,4-phenyldiamine dihydrochloride with 5-amino-2-chloropyridine. H ΝMR (DMSO-d 6 ): 8.18 (d, J=2.68 Hz, IH), 7.64 (dd, J=8.75, 2.89 Hz, IH), 7.50ppm (d, J=8.75 Hz, IH). EI m/z 358 (20, M + ), 127 (100). Anal, calcd. for C π H 4 ClF 5 Ν 2 O 2 S: C 36.83, H 1.12, N 7.81, S 8.94, Cl 9.90. Found: C 37.00, H 1.16, N 7.78, S 8.98, Cl 10.01. White crystals with M.P.=144-145 °C. Example 37 2-Hydroxy- 1 -methoxy-4-(N-(5-hydroxypentyl)-pentafluoropheny Isulfonamido) benzene. N-(5-hydroxypentyl)-2-hydroxy-l-methoxy-4-aminobenzene as prepared by reductive amination of 5-amino-2-methoxy phenol with glutaric dialdehyde with ΝaBH 4 in MeOH. 2-Hydroxy- 1 -methoxy-4-(N-pentane-5-ol-pentafluorophenylsulfonamido) benzene was prepared in a manner similar to that of example 1 by replacing N N-dimethy 1-1,4-phenyldiamine dihydrochloride with N-(5- hydroxypentyl)-2-hydroxy-l-methoxy-4-aminobenzene. ! H ΝMR (CDC1 3 ): 6.78(d, J=8.6 Hz, IH), 6.71(dd, J=8.59, 2.48 Hz, IH), 6.63(d, J=2.48 Hz, IH), 3.88(s, 3H), 3.7(t, J=6.8 Hz, 2H), 3.6(t, J=6.39 Hz, 2H), 1.5ppm (m, 6H). Anal, calcd. for C 18 H 18 F 5 ΝO 5 S: C 47.47, H 3.98, N 3.08, S 7.04. Found: C 47.47, H 4.04, N 3.11, S 6.97. White crystals with M.P.=118°. Example S 4-( 1 , 1 -Dimethyl)ethoxy- 1 -pentafluoropheny lsulfonamido- benzene. The compound was prepared in a manner similar to example 46 by replacing 3-chloroaniline with 4-/-butoxyaniline. 4-f-Butoxy aniline was prepared by the method of Day (J. Med. Chem. 1975, 18, 1065). 'H NMR (CDC1 3 ): d 7.07 (m, 2), 6.92 (m, 2), 6.88 (m, 1), 1.31 (s, 9). MS (EI): m/z 395 (1, M + ), 339 (28), 108 (100). Anal. Calcd. for C 16 H 14 F 5 NO 3 S: C, 48.61; H, 3.57; N, 3.54; S, 8.11. Found: C, 48.53; H, 3.60; N, 3.50; S, 8.02. Example 39 1 -Bromo-3 -hydroxy-4-methoxy- 1 -pentafluorobenzenesulfonamidobenzene. The compound was prepared by bromination of the compound of example 6 with N-bromosuccinamide in dichloromethane. 'H ΝMR (CDC1 3 ) 7.28 (br s, IH), 7.21 (d, J=9Hz, IH), 6.80 (d, J=9Hz, IH), 6.05 (s, IH), 3.89ppm (s, 3H). El, m/z (relative abundance) : 449 (25), 447 (25), 218 (100), 216 (100). Anal, calcd. for C13H8BrlF5ΝlO4Sl : C 34.84, H 1.57, N 3.13, S 7.15. Found: C 34.75, H 1.60, N 3.07, S 7.08. Example 40 2-Bromo-4-methoxy-5-hydroxy- 1-pentafluorobenzenesulfonamidobenzene. The compound was prepared by bromination of the compound of example 6 with N-bromosuccinamide in dichloromethane. 'H ΝMR (CDC1 3 ) 7.28 (s, IH), 7.16 (br s, IH), 6.91 (s, IH), 5.63 (s, IH), 3.85ppm (s, 3H). EI, m/z (relative abundance) : 449 (25), 447 (25), 218 (100), 216 (100). Anal, calcd. for C13H8BrlF5ΝlO4Sl : C 34.84, H 1.57, N 3.13, S 7.15. Found: C 34.84, H 1.57, N 3.05, S 7.06. Example 41 l-Bromo-4-fluoro-5-methoxy-2-pentafluorophenylsulfonamidobenzene. The compound was prepared by bromination of the compound of example 7 with bromine water. Η NMR (CDC1 3 ): 7.49 (d, J-11.72 Hz, IH), 7.21 (s, IH), 7.04 (d, J=8.2 Hz, IH), 3.84 ppm (s, 3H). EI m/z: 449 (20, M + ), 451 (20 ), 228 (100), 230 (100). Anal. Calcd. for C 13 H 6 BrF 6 NO 3 S: C 34.69, H 1.34, N 3.11, S 7.12, Br 17.75. Found: C34.76, H 1.29, N 3.05, S 7.12, Br 17.68. White crystals with M.P.= 109 °C. Example 42 2 -Hydroxy- 1 -methoxy-4-pentafluorobenzenesulfonamidobenzene sodium salt. The compound was prepared by treating the compound of example 6 with an equimolar amount of IN NaOH ( j . The mixture was then lyophilized and the residue recrystallyzed from ethyl acetate/ ether. 'H NMR (DMSO) 8.40 (s, IH), 6.57 (d, J=9Hz, IH), 6.39 (d, J=2Hz, IH), 6.24 (dd, J=9, 2Hz, IH), 3.62ppm (s, 3H). Anal, calcd. for C13H7F5NlNalO4Sl : C 39.91, H 1.80, N 3.58, Na 5.88, S 8.19. Found: C 39.79, H 1.86, N 3.50, Na 5.78, S 8.07. Example 43 2-Hydroxy-l-methoxy-4-pentafluorobenzenesulfonamidobenzene potassium salt. The compound was prepared in a manner similar to that of example 42 by replacing IN NaOH with IN KOH. 'H NMR (DMSO) 8.30 (br s, IH), 6.55 (d, J=9Hz, IH), 6.36 (d, J=2Hz, IH), 6.25 (dd, J=9, 2Hz, IH), 3.61ppm (s, 3H). Anal, calcd. for C13H7F5K1N1O4S1: C 38.33, H 1.73, N 3.44, S 7.87. Found: C 38.09, H 1.79, N 3.39, S 7.97. Example 44 2-Fluoro-l-methoxy-4-pentafluorobenzenesulfonamidobenzene potassium salt. The compound was prepared in a manner similar to that of example 43 by replacing the compound from example 6 with example 7. 'H NMR (DMSO) 6.80 (t, J=10Hz, IH), 6.72 (dd, J=9, 2Hz, IH), 6.54 (dd, J=9, 2Hz, IH), 3.68ppm (s, 3H). Anal, calcd. for C13H6F6 1N1O3S1 : C 38.15, H 1.48, N 3.42, S 7.83. Found: C 38.09, H 1.51, N 3.35, S 7.73. M.P.=202-205 °C. Example 45 2-Fluoro-l-methoxy-4-pentafluorobenzenesulfonamidobenzene sodium salt. The compound was prepared in a manner similar to that of example 44 by replacing IN KOH with IN NaOH. 'H NMR (DMSO) 6.80 (t, J=10Hz, IH), 6.71 (dd, J=9, 2Hz, IH), 6.53 (dd, J=9, 2Hz, IH), 3.69ppm (s, 3H). Anal, calcd. for C13H6F6NlNalO3Sl : C 39.71, H 1.54, N 3.56, Na 5.85, S 8.15. Found: C 39.56, H 1.62, N 3.49, Na 5.88, S 8.08. Example 46 3-Chloro-l -pentafluoropheny lsulfonamidobenzene. To a solution of pentafluorobenzenesulfonyl chloride (0.15 mL, 1.00 mmol) in MeOH (4 mL) was added 3-chloroaniline (260 mg, 2.04 mmol). After stirring at rt for 1 h, the reaction mixture was concentrated under reduced pressure and the residue was taken up in EtOAc and then filtered through a plug of silica gel. The filtrate was concentrated to give a yellow oil that upon chromatography provided 265 mg (74%) of product. Η NMR (CDC1 3 ): d 7.28-7.24 (m, IH), 7.21-7.17 (m, 2H), 7.10-7.08 (m, IH), 7.07 (s, IH). MS (EI): m/z 357 (42, M + ), 258 (76), 126 (87), 99 (100). Anal. Calcd. for C 12 H 5 ClF 5 NO 2 S: C, 40.30; H, 1.41; N, 3.92; S, 8.96. Found: C, 40.18; H, 1.35; N, 3.84; S, 8.90. Example 47 4-Chloro-l-pentafluorophenylsulfonamidobenzene. The compound was prepared in a manner similar to that described in example 46 by replacing 3-chloroaniline with 4-chloroaniline. »H NMR (CDC1 3 ): d 7.30 (m, 2H), 7.20 (m, IH), 7.14 (m, 2H). MS (EI): m/z 357 (27, M + ), 258 (38), 126 (100), 99 (85). Anal. Calcd. for C 12 H 5 ClF 5 NO 2 S: C, 40.30; H, 1.41; N, 3.92; S, 8.96. Found: C, 40.19; H, 1.37; N, 3.87; S, 8.88. Example 48 3-Nitro-l-pentafluorophenylsulfonamidobenzene. The compound was prepared in a manner similar to that described in example 46 by replacing 3-chloroaniline with 3-nitroaniline. 'H NMR (CDC1 3 ): d 8.14 (s, IH), 8.06-8.03 (m, 2H), 7.66-7.63 (m, IH), 7.55 (m, IH). MS (EI): m/z 368 (54, M + ), 137 (70), 91 (100). Anal. Calcd. for C 12 H 5 F 5 N 2 O 4 S: C, 39.14; H, 1.37; N, 7.61; S, 8.71. Found: C, 39.39; H, 1.45; N, 7.46; S, 8.58. Example 49 4-Methoxy-l-pentafluorophenylsulfonamido-3-trifluoromethyl benzene. The compound was prepared in a manner similar to that described in example 46 by replacing 3-chloroaniline with 4-methoxy-3-trifluoromethylaniline which was obtained by the hydrogenation of the corresponding nitro compound. White solid, mp 121-123 °C. Η NMR (CDC1 3 ): d 7.43-7.37 (m, 2H), 6.96 (d, J= 8.8, IH), 3.88 (s, 3H). MS (EI): m/z 421 (16, M + ), 190 (100). Anal. Calcd. for C 14 H 7 F 8 NO 3 S: C, 39.92; H, 1.67; N, 3.32; S, 7.61. Found: C, 40.17; H, 1.68; N, 3.28; S, 7.67. Example 5Q 4-Methoxy-l-(N-(2-propenyl)pentafluorophenylsulfonamido)benzene. To a solution of 4-methoxy-l-pentafluorophenylsulfonamidobenzene (448 mg, 1.27 mmol) in THF (3 mL) was added triphenylphosphine (333 mg, 1.27 mmol) and allyl alcohol (0.09 mL, 1.27 mmol). Diethylazodicarboxylate (0.20 mL, 1.27 mmol) was added and the mixture was stirred at rt. After 1 h, the reaction mixture was poured onto saturated ΝaCl (10 mL) and extracted with CH 2 C1 2 (3 10 mL). The combined organic extracts were washed with saturated ΝaHCO 3 (10 mL) and dried (MgSO 4 ). Concentration followed by flash chromatography (25:25: l/hexanes:CH 2 Cl 2 :EtO Ac) provided 451 mg (90%) of product as a white solid, mp 59-60 °C. 'H NMR (CDC1 3 ): d 7.06 (m, 2H), 6.85 (m, 2H), 5.79 (m, IH), 5.15 (s, IH), 5.11 (m, IH), 4.37 (d, J= 6.3, 2H), 3.80 (s, 3H). MS (EI): m/z 393 (33, M + ), 162 (100), 134 (66). Anal. Calcd. for C 16 H n F 5 NO 3 S: C, 48.98; H, 2.83; N, 3.57; S, 8.17. Found: C, 49.13; H, 3.15; N, 3.63; S, 8.15. Example 51 l-(N-(3-Butenyl)pentafluorophenylsulfonamido)-4-methoxybenzene. The compound was prepared in a manner similar to that described in example 50 by replacing allyl alcohol with 3-buten-l-ol. White solid, mp 64-66 °C. >H ΝMR (CDC1 3 ): d 7.08 (m, 2H), 6.86 (m, 2H), 5.74 (m, IH), 5.10-5.04 (m, 2H), 3.83 (m, 2H), 3.81 (s, 3H), 2.25 (q, J= 6.9, 2H). MS (EI): m/z 407 (13, M + ), 366 (24), 135 (100). Anal. Calcd. for C ]7 H, 4 F 5 ΝO 3 S: C, 50.13; H, 3.46; N, 3.44; S, 7.87. Found: C, 50.25; H, 3.51 ; N, 3.43; S, 7.81. Example 52 4-Methoxy-l-(N-(4-pentenyl)pentafluorophenylsulfonamido)benzene. The compound was prepared in a manner similar to that described in example 50 by replacing allyl alcohol with 4-penten-l-ol. Low melting semi-solid. 'H ΝMR (CDC1 3 ): d 7.08 (m, 2H), 6.87 (m, 2H), 5.74 (m, IH), 5.02-4.96 (m, 2H), 3.81 (s, 3H), 3.76 (t,J= 7.04, 2H), 2.11 (q, J= 6.9, 2H), 1.60 (pentet, J= 7.3, 2H). MS (EI): m/z 421 (30, M + ), 190 (100). Anal. Calcd. for C 18 H 16 F 5 ΝO 3 S: C, 51.31; H, 3.83; N, 3.32; S, 7.61. Found: C, 51.44; H, 3.89; N, 3.38; S, 7.54. Example 5 1 -(N-(2,3-Dihydroxypropyl)pentafluorophenylsulfonamido)-4-methoxy benzene. To a solution of 4-methoxy-l-(N-(2-propenyl)pentafluorophenylsulfonamido)benzene (101 mg, 0.26 mmol) in acetone:water (8:1, 1 mL) at rt was added N-methylmorpholine N-oxide (34.0 mg, 0.29 mmol) and OsO 4 (0.10 mL of 0.16 M solution in H 2 0, 1.60 x 10 "2 mmol). After stirring at rt for 18 h, the reaction mixture was treated with saturated ΝaHSO 3 (5 mL) and allowed to stir at rt. After 1 h, the reaction mixture was poured onto saturated NaHSO 3 (5 mL) and extracted with CH 2 C1 2 (3 x 10 mL). The combined organic extracts were dried (MgSO 4 ) and concentrated. Flash chromatography (1:1, 1 :2/hexanes:EtO Ac) afforded 90 mg (83%) of product as a white solid, mp 130-131 °C. Η NMR (CDC1 3 ): d 7.11 (m, 2H), 6.85 (m, 2H), 3.78 (s, 3H), 3.90-3.65 (m, 5H). Anal. Calcd. for C ]6 H 13 F 5 NO 5 S: C, 45.08; H, 3.07; N, 3.29; S, 7.52. Found: C, 45.09; H, 3.33; N, 3.27; S, 7.46. Example 54 1 -(N-(3 ,4-Dihydroxybutyl)pentafluoropheny lsulfonamido)-4-methoxybenzene. The compound was prepared in a manner similar to that described in example 53 by replacing 4-methoxy- 1 -(N-(2-propenyl)pentafluorophenylsulfonamido)benzene with l-(N-(3-butenyl)pentafluorophenylsulfonamido)-4-methoxybenzene. White solid, mp 126-128 °C. 'H ΝMR (CDC1 3 ): d 7.10 (m, 2H), 6.88 (m, 2H), 4.13 (m, IH), 3.96 (m, IH), 3.81 (s, 3H), 3.78-3.73 (m, IH), 3.64 (dd, 1, J= 2.9, 10.7, IH), 3.47 (dd, J= 7.3, 11.2; IH), 2.67 (bs, IH), 1.92 (bs, IH), 1.62 (m, 2H). Example 55 l-(N-(4,5-Dihydroxypentyl)pentafluorophenylsulfonamido)-4-methoxybenzene. The compound was prepared in a manner similar to that described in example 53 by replacing 4-methoxy- 1 -(N-(2-propenyl)pentafluorophenylsulfonamido)benzene with 4-methoxy-l-(N-(4-pentenyl)pentafluorophenylsulfonamido)benzene. White solid, mp 116-118 °C. 1H ΝMR (CDC1 3 ): d 7.07 (m, 2H), 6.86 (m, 2H), 3.80 (s, 3H), 3.78 (m, 2H), 3.71-3.62 (m, 2H), 3.43 (dd, J= 7.5, 10.8; IH), 1.90 (bs, 2H), 1.66-1.49 (m, 4H). Anal. Calcd. for C, 8 H 18 F 5 ΝO 5 S: C, 47.48; H, 3.98; N, 3.08; S, 7.04. Found: C, 47.58; H, 3.95; N, 3.06; S, 6.95. Exam le 56 1 -(N-(4-hydroxybuty l)pentafluorophenylsulfonamido)-4-methoxybenzene. To a solution of 1 -(N-(3-butenyl)pentafluorophenylsulfonamido)-4-methoxy benzene (410 mg, 1.01 mmol) in THF (6.5 mL) at -78 * C was added BH 3 .THF (1.00 mL of a 1 M solution in THF, 1.00 mmol). After stirring at -78 °C for 1 h and at 0 "C for 1 h, the reaction mixture was treated with H 2 O (20 mL) and sodium perborate (513 mg, 5.14 mmol). After stirring at rt for 2 h, the mixture was poured onto H 2 O (20 mL) and extracted with CH 2 C1 2 (3 x 15 mL). The combined organic extracts were washed with sat. ΝaCl (20 mL) and dried (MgSO 4 ). Concentration followed by chromatography (2:l/hexanes:EtOAc) afforded 270 mg (64%) of product as a white solid, mp 88-90 °C. Η ΝMR (CDC1 3 ): d 7.08 (m, 2H), 6.85 (m, 2H), 3.80 (s, 3H), 3.77 (m, 2H), 3.64 (t, J= 6.0; 2H), 1.63-1.55 (m, 5H), 1.50 (bs, IH). Anal. Calcd. for C 17 H 16 F 5 ΝO 4 S: C, 48.00; H, 3.79; N, 3.29; S, 7.54. Found: C, 48.08; H, 3.76; N, 3.34; S, 7.46. Example 57 4-Methoxy- 1 -(N-(5-hydroxypentyl)pentafluorophenylsulfonamido)-benzene. The compound was prepared in a manner similar to that described in example 56 by replacing 1 -(N-(3-butenyl)pentafluorophenylsulfonamido)-4-methoxy benzene with 4-methoxy-l-(N-(4-pentenyl)pentafluorophenylsulfonamido)benzene. White solid, mp 96-97 °C. 'H ΝMR (CDC1 3 ): d 7.08 (m, 2H), 6.86 (m, 2H), 3.81 (s, 3H), 3.76 (t, J = 6.8, 2H), 3.62 (t, J= 6.4; 2H), 1.58-1.43 (m, 6H). Anal. Calcd. for C l8 H l8 F 5 ΝO 4 S: C, 49.20; H, 4.13; N, 3.19; S, 7.30. Found: C, 49.11; H, 4.09; N, 3.14; S, 7.19. Example 58 4-Methoxy-3-nitro-l-pentafluorophenylsulfonamidobenzene. The compound was prepared in a manner similar to example 46 by replacing 3-chloroaniline with 4-methoxy-3-nitroaniline which was prepared by the method of Norris (Aust. J. Chem. 1971, 24, 1449). Orange-yellow solid, mp 95-97 °C. Η NMR (CDC1 3 ): d 7.64 (d, J= 2.7; IH), 7.51 (dd, J = 2.7, 9.0; IH), 7.09 (s, IH), 7.09 (d, J= 9.0; IH), 3.95 (s, 3H). Anal. Calcd. For C 13 H 7 F 5 N 2 O 5 S: C, 39.21; H, 1.77; N, 7.03; S, 8.05. Found: C, 39.19; H, 1.73; N, 6.97; S, 7.95. Example 59 3 -Amino-4-methoxy-l -pentafluoropheny lsulfonamidobenzene. To a solution of 4-methoxy-3 -nitro- 1-pentafluorophenylsulfonamidobenzene (627 mg, 1.58 mmol) in ethanol (10 mL) was added 10% Pd/C (51 mg). The resulting mixture was stirred under an atmosphere of hydrogen gas at 1 atm pressure. After 14 h, the mixture was passed through a pad of celite and the filtrate was concentrated to give a solid residue. Silica gel chromatography (2:1, l :l/hexanes:EtOAc) yielded 542 mg (93%) of product as a white solid, mp 142-143 °C. 1H NMR (DMSO-d 6 ): 10.64 (s, 1), 6.68 (d, J= 8.4; IH), 6.44 (d, J = 2.1; IH), 6.30 (d, J= 2.1, 8.4; IH), 4.88 (bs, 2H), 3.69 (s, 3H). Anal. Calcd. for C, 3 H 9 F 5 N 2 O 3 S: C, 42.40; H, 2.46; N, 7.61; S, 8.71. Found: C, 42.29; H, 2.36; N, 7.52; S, 8.60. Example 60 4-Butoxy-l-pentafluorophenylsulfonamidobenzene. To a solution of pentafluorobenzenesulfonyl chloride (203 mg, 0.763 mmol) in MeOH (4 mL) was added 4-butoxyaniline (0.26 mL, 1.53 mmol). After stirring at rt for 1 h, the reaction mixture was poured onto 1 HCl (15 mL) and extracted with CH 2 C1 2 (3 10 mL). The combined organic extracts were washed with saturated NaCl (10 mL) and dried (MgSO 4 ). Concentration followed by flash chromatography (25:25 :l/hexanes: CH 2 Cl 2 :EtOAc) provided 189 mg (63%) of product. 'H NMR (CDC1 3 ): d 7.07 (m, 2H), 6.86 (s, IH), 6.80 (m, 2H), 3.89 (t, J= 6.5; 2H), 1.73 (m, 2H), 1.46 (m, 2H), 0.95 (t, J= 7.5; 2H). MS (EI): m/z 395 (30, M + ), 164 (35), 108 (100). Anal. Calcd. for C, 6 H 14 F 5 NO 3 S: C, 48.61; H, 3.57; N, 3.54; S, 8.11. Found: C, 48.54; H, 3.53; N, 3.50; S, 8.02. Example 61 1 -Pentafluoropheny lsulfonamido-4-phenoxy benzene. The compound was prepared in a manner similar to that described in example 60 by replacing 4-butoxyaniline with 4-phenoxyaniline. Η NMR (CDC1 3 ): 7.36-7.30 (m, 2H), 7.15-7.10 (m, 3H), 6.99 (s, IH), 6.98-6.90 (m, 4H). MS (EI): m/z 415 (32, M + ), 184 (100), 77 (66). Anal. Calcd. for C 18 H 10 F 5 NO 3 S: C, 52.05; H, 2.43; N, 3.27; S, 7.72. Found: C, 51.78; H, 2.45; N, 3.25; S, 7.53. Example 62 4-Benzyloxy-l-pentafluorophenylsulfonamidobenzene. The compound was prepared in a manner similar to that described in example 60 by replacing 4-butoxyaniline with 4-benzyloxy aniline. 4-Benzyloxyaniline was obtained from the commercially available hydrochloride salt by treatment with aqueous NaOH. Η NMR (CDC1 3 ): 7.38-7.37 (m, 41 7.36-7.32 (m, IH), 7.10-7.08 (m, 2H), 7.91-7.88 (m, 2H), 6.78 (s, IH), 5.01 (s, IH). MS (EI): m/z 429 (19, M + ), 91 (100). Anal. Calcd. for C 19 H 12 F 5 NO 3 S: C, 53.14; H, 2.82; N, 3.26; S, 7.45. Found: C, 53.07; H, 2.78; N, 3.21; S, 7.35. Example 63 4-Methylmercapto-l-pentafluorophenylsulfonamidobenzene. The compound was prepared in a manner similar to that described in example 60 by replacing 4-butoxyaniline with 4-(methylmercapto)aniline. *H NMR (CDC1 3 ): 7.17 (m, 2H), 7.09 (m, 2H), 6.89 (m, IH), 2.44 (s, 3H). MS (EI): m/z 369 (24, M + ), 138 (100), 77 (66). Anal. Calcd. for C 13 H 8 F 5 NO 2 S 2 : C, 42.28; H, 2.18; N, 3.79; S, 17.36. Found: C, 42.20; H, 2.21; N, 3.72; S, 17.28. Example 64 2-Methoxy-l-pentafluorophenylsulfonamidobenzene. The compound was prepared in a manner similar to that described in example 60 by replacing 4-butoxyaniline with o-anisidine. 'H NMR (CDC1 3 ): d 7.54 (dd, J= 1.5, 8.0; IH), 7.13 (dt, J= 1.5, 8.0; IH), 6.94 (dt, J= 1.2, 8.0; IH), 6.84 (dd, J= 1.2, 8.0; IH), 3.79 (s, 3H). MS (EI): m/z 353 (82, M + ), 122 (100), 94 (95). Anal. Calcd. for C 13 H 8 F 5 NO 3 S: C, 44.19; H, 2.28; N, 3.97; S, 9.06. Found: C, 44.10; H, 2.26; N, 3.92; S, 9.03. Example 65 4-Allyloxy-l-pentafluorophenylsulfonamidobenzene. The compound was prepared in a manner similar to that described in example 60 by replacing 4-butoxyaniline with 4-allyloxyaniline. 4-Allyloxyaniline was prepared by the method of Butera (J. Med. Chem. 1991, 34, 3212). »H NMR (CDC1 3 ): 7.08 (m, 2H), 6.87 (m, IH), 6.82 (m, 2H), 6.04-5.94 (m, IH), 5.39-5.34 (m, IH), 5.29-5.25 (m, IH), 4.48-4.46 (m, 2H). MS (EI): m/z 379 (11, M + ), 148 (32), 41 (100). Anal. Calcd. for C 15 H 10 F 5 NO 3 S: C, 47.50; H, 2.66; N, 3.96; S, 8.45. Found: C, 47.53; H, 2.68; N, 3.62; S, 8.37. Example 66 1 -Pentafluoropheny lsulfonamido-4-propoxybenzene. The compound was prepared in a manner similar to that described in example 60 by replacing 4-butoxyaniline widi 4-propoxyaniline. 4-Propoxyaniline was obtained by catalytic hydrogenation of 4-allyloxynitrobenzene. 4-Allyloxynitrobenzene was prepared by the method of Butera (J. Med Chem. 1991, 34, 3212). Η NMR (CDC1 3 ): 7.09 (m, 2H), 6.82 (m, 2H), 6.78 (m, IH), 3.87 (t, J= 6.5; 2H), 1.78 (m, 2H), 1.02 (t, J= 7.4; 3H). MS (EI): m/z 381 (20, M + ), 150 (40), 108 (100). Anal. Calcd. for C 15 H 12 F 5 NO 3 S: C, 47.25; H, 3.17; N, 3.67; S, 8.41. Found: C, 47.01; H, 3.20; N, 3.61; S, 8.31. Example 67 4-(l-Methyl)ethoxy-l-pentafluorophenylsulfonamidobenzene. The compound was prepared in a manner similar to that described in example 60 by replacing 4-butoxyaniline with 4-isopropoxyaniline. 4-Isopropoxyaniline was prepared from 4-fluoronitrobenzene in analogy to the method of Day (J. Med. Chem. 1975, 18, 1065). H NMR (CDC1 3 ): 7.08 (m, 2H), 7.00 (s, IH), 6.81 (m, 2H), 4.48 (heptet, J= 6.1 ; IH), 1.30 (d, J= 6.04; 6H). MS (EI): m/z 381 (7, M + ), 339 (8), 108 (100). Anal. Calcd. for C, 5 H I2 F 5 NO 3 S: C, 47.25; H, 3.17; N, 3.67; S, 8.41. Found: C, 47.08; H, 3.18; N, 3.60; S, 8.34. Example 68 1-Pentafluorobenzenesulfonyloxybenzene. To a stirred solution of phenol (0.068g, 0.729mmol) in dimethylformamide (3.65 mL) at 25 °C is added pentafluorobenzene sulfonyl chloride (0.135mL, 0.91 lmmol), followed by sodium carbonate (0.116g, 1.09mmol), and the reaction mixture is stirred for 18 hours. The reaction mixture is diluted with ethyl acetate (50mL), washed with 20% ammonium chloride (2 x 20mL), and saturated sodium chloride (2 x 20mL). The organic layer is dried (sodium sulfite), and the ethyl acetate removed under vacuum. Column chromatography (3/1 ethyl acetate/hexane) yields the tide compound. Example 69 1-Pentafluorobenzenesulfonylindole. To a stirred solution of indole (0.085g, 0.729mmol) in dimethylformamide (3.65 mL) at 25 °C is added pentafluorobenzene sulfonyl chloride (0.135mL, 0.91 lmmol), followed by sodium carbonate (0.116g, 1.09mmol), and the reaction mixture is stirred for 18 hours. The reaction mixture is diluted with ethyl acetate (50mL), washed with 20% ammonium chloride (2 x 20mL), and saturated sodium chloride (2 x 20mL). The organic layer is dried (sodium sulfite), and the ethyl acetate removed under vacuum. Column chromatography (3/1 ethyl acetate/hexane) yields the title compound. Example 10 2-Fluoro-l -methoxy -4-pentafluorophenylsulfιnamidobenzene. To 3-fluoro-p-anisidine (3g, 21.2mmol) suspended in THF (50mL) with pyridine (1.84g, 23.3mmol) at 0 °C under argon is added dropwise pentafluorobenzenesulfinyl chloride (5.3g, 21.2mmol). The reaction mixture is stirred for 30 min. at 0 °C and allowed to warm to ambient temperature. The reaction mixture is strirred at room temperature and followed by TLC. After the reaction is completed the mixture is diluted with ethyl acetate and the reaction quenched with water. The layers are separated and the aqueous layer extracted twice with ethyl acetate. The organic layers are combined and dried with brine and with Na^O^ The solvent is evaporated and the residue purified by chromatography on silica to give the title compound. Example 71 2-Analino-3-pentafluorophenylsulfonamidopyridine. To a solution of pentafluorophenylsulfonyl chloride (863 mg, 3.24 mmol) in pyridine (9 mL) at rt was added 3-amino-2-analinopyridine (600 mg, 3.24 mmol). After stirring at rt overnight the reaction mixture was concentrated at reduced pressure and the residue partitioned between 1 M Hcl (50 mL) and CH2C12 (50 mL). The organic extract was dried and concentrated to give an oil which was purified by MPLC to give 377 mg (28%) of product as an orange solid. H' NMR (CDC1 3 ): 8.50 (bs, IH), 7.80 (d, J=5.1, IH), 7.61 (d, J=8.0, IH), 7.32 (t, J=8.0, 2H), 7.25 (d, J=8.0, 2H), 7.11 (t, J=7.3, IH), 6.80 (dd, J=5.6, 7.7, IH), 4.20 (bs, IH). MS (FAB): m/z 438 (M +Na ), 416 (M+H). Example 72 Compounds were evaluated for their ability to increase LDL receptor expression in Hep G2 cells using western-blot analysis as described in Tam et al., J. Biol. Chem., 266, 16764 ( 1991 ). The data presented (EC maχ ) reflect the minimum concentration at which a maximal induction of LDL receptor was observed for each compound. In all cases, the level of induction was greater than that observed under lipid-free conditions (activated system). Compound E£^ium) Example 1 0.5 Example 2 5 Example 3 5 Example 4 < 5 Example 6 0.15 Example 7 0.5 Example 8 0.5 Example 9 5 Example 12 5 Example 15 15 Example 17 5 Example 24 15 Example 25 15 Example 30 15 Example 31 <5 Example 32 1.5 All publications and patent applications cited in this specification are herein incoφorated by reference as if each individual publication or patent application were specifically and individually indicated to be incoφorated by reference. Although the foregoing invention has been described in some detail by way of illustration and example for puφoses of clarity of understanding, it will be readily apparent to those of ordinary skill in the art in light of the teachings of diis invention that certain changes and modifications may be made thereto without departing from the spirit or scope of the appended claims.

Claims: WHAT IS CLAIMED IS; 1. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: Y is -S(O)- or -S(O) 2 -; and Z is -NR'R 2 or -OR 3 ; wherein R' and R 2 are independently selected from hydrogen, substituted or unsubstituted (C 1 -C 10)alky 1, substituted or unsubstituted (Cl-ClO)alkoxy, substituted or unsubstituted (C3-C6)alkenyl, substituted or unsubstituted (C2-C6)heteroalkyl, substituted or unsubstituted (C3-C6)heteroalkenyl, substituted or unsubstituted (C3-C6)alkynyl, substituted or unsubstituted (C3-C8)cycloalkyl, substituted or unsubstituted (C5-C7)cycloalkenyl, substituted or unsubstituted (C5-C7)cycloalkadienyl, substituted or unsubstituted aryl, substituted or unsubstituted aryloxy, substituted or unsubstituted aryl-(C3-C8)cycloalkyl, substituted or unsubstituted aryl-(C5-C7)cycloalkenyl, substituted or unsubstituted aryloxy-(C3-C8)cycloalkyl, substituted or unsubstituted aryl-(Cl-C4)alkyl, substituted or unsubstituted aryl-(C 1 -C4)alkoxy, substituted or unsubstituted aryl-(Cl-C4)heteroalkyl, substituted or unsubstituted aryl-(C3-C6)alkenyl, substituted or unsubstituted aryloxy-(Cl-C4)alkyl, substituted or unsubstituted aryloxy-(C2-C4)heteroalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaryloxy, substituted or unsubstituted heteroaryl-(Cl-C4)alkyl, substituted or unsubstituted heteroaryl-(Cl-C4)alkoxy, substituted or unsubstituted heteroaryl-(C 1 -C4)heteroalkyl, substituted or unsubstituted heteroaryl-(C3-C6)alkenyl, substituted or unsubstituted heteroaryloxy-(Cl-C4)alkyl, and substituted or unsubstituted heteroaryloxy-(C2-C4)heteroalkyl, wherein R 1 and R 2 may be connected by a linking group E to give a substituent of the formula wherein E represents a bond, (C1-C4) alkylene, or (C1-C4) heteroalkylene, and the ring formed by R', E, R 2 and the nitrogen atom contains no more than 8 atoms; and where R 3 is a substituted or unsubstituted aryl or heteroaryl group, wherein said compound I has pharmacological activity. 2. The composition of claim 1 , wherein, in the compound of formula I, Y is SO 2 and Z is NR'R 2 ; wherein R 2 is optionally substituted aryl or optionally substituted heteroaryl. 3. The composition of claim 2, wherein R' is hydrogen or lower alkyl, R 2 is optionally substituted phenyl or optionally substituted pyridyl, and there is no linking group E between R' and R 2 . 4. The composition of claim 3, wherein R' is hydrogen or methyl and R 2 is substituted phenyl, wherein the substituents on R 2 , ranging in number from one to four, are independently chosen from lower alkyl, hydroxy, lower alkoxy, amino optionally substituted with one or two lower alkyls, optionally substituted arylamino, optionally substituted heteroarylamino, optionally substituted phenoxy, and halogen. 5. The composition of claim 4, wherein R 1 is hydrogen and R 2 is substituted phenyl, wherein the substituents on R 2 are independently chosen from amino, (lower)alkylamino, and di(lower)alkylamino, and are located at one or more of positions 3- and 4- of the phenyl ring, in relation to the sulfonamido group. 6. The composition of claim 5, wherein the compound is 4-(N,N-Dimethylamino)- 1 -pentafluoropheny lsulfonamidobenzene, 4-(N,N-Diethy lamino)- 1 -pentafluoropheny lsulfonamidobenzene, 3-(N, N-Dimethylamino)- 1 -pentafluorophenylsulfonamidobenzene, 4-Ajnino-l-pentafluorophenylsulfonamidobenzene, or 4-(N,N-Dimethylamino)- 1 -pentafluorophenylsulfonamidobenzene hydrochloride. 7. The composition of claim 6, wherein the compound is 4-(N, N-Dimethylamino)- 1 -pentafluoropheny lsulfonamidobenzene. 8. The composition of claim 2, wherein the compound is Pentafluorophenylsulfonamidobenzene. 9. The composition of claim 3, wherein R 1 is hydrogen, and R 2 is phenyl substituted at positions 3- and 4-, in relation to the sulfonamido group, with a divalent moiety that forms a 5- or 6- membered ring together with carbons 3- and 4- of the phenyl ring. 10. The composition of claim 9, wherein the divalent moiety is: -OCH 2 CH 2 O-, -OCH 2 O-, -C=CΝH-, or -C=NNH-. 11. The composition of claim 10, wherein the compound is l,2-Ethylenedioxy-4-pentafluorophenylsulfonamidobenzene, 1 ,2-Methylenedioxy-4-pentafluorophenylsulfonamidobenzene, 5-Pentafluorophenylsulfonamidoindazole, or 5 -Pentafluoropheny lsulfona idoindole . 12. The composition of claim 4, wherein R 1 is hydrogen, and the substituents on R 2 are independently selected from halogen, hydroxy, lower alkyl, lower alkoxy, amino, (lower)alkylamino, and di(lower)alkylamino. 13. The composition of claim 12, wherein the substituents on R 2 are independently selected from bromo, chloro, fluoro, hydroxy, methoxy, ethoxy, amino, and dimethylamino. 14. The composition of claim 13, wherein the substituents on R 2 are independently selected from bromo, chloro, fluoro, hydroxy, methoxy, and ethoxy. 15. The composition of claim 12, wherein the substituents on R 2 are at one or more of positions 3- and 4- of the phenyl ring, in relation to the sulfonamido group. 16. The composition of claim 15, wherein R 2 is monosubstituted phenyl. 17. The composition of claim 16, wherein the compound is 4-Methoxy- 1 -pentafluorophenylsulfonamidobenzene, 3 -Hydroxy- 1 -pentafluorophenylsulfonarnidobenzene, 4-Hydroxy- 1 -pentafluoropheny lsulfonamidobenzene, 4-Ethoxy- 1 -pentafluorophenylsulfonamidobenzene, 3 -Ethoxy- 1 -pentafluorophenylsulfonamidobenzene, 3-Phenoxy- 1 -pentafluorophenylsulfonamidobenzene, 3-Methoxy- 1 -pentafluorophenylsulfonamidobenzene, or 4- r/-Butoxy- 1 -pentafluorophenylsulfonamidobenzene. 18. The composition of claim 16, wherein the compound is 3 -Chloro- 1 -pentafluorophenylsulfonamidobenzene, or 4-Chloro- 1 -pentafluoropheny lsulfonamidobenzene. 19. The composition of claim 15, wherein R 2 is disubstituted phenyl. 20. The composition of claim 19, wherein the compound is l,2-Dimethoxy-4-pentafluorophenylsulfonamidobenzene, 2-Hydroxy- 1 -methoxy -4-pentafluorophenylsulfonamidobenzene, l,2-Dihydroxy-4-pentafluorophenylsulfonamidobenzene, 2-Hydroxy-l-methoxy-4-pentafluoropheny lsulfonamidobenzene, monosodium salt, or 2-Hydroxy-l-methoxy-4-pentafluorophenylsulfonamidobenzene, monopotassium salt. 21. The composition of claim 19, wherein the compound is 2-Fluoro- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, 2-Bromo- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, 2-Chloro- 1 -methoxy -4-pentafluorophenylsulfonamidobenzene, 2-Fluoro-l-methoxy-4-pentafluorophenylsulfonamidobenzene, sodium salt, or 2-Fluoro-l-methoxy-4-pentafluorophenylsulfonamidobenzene, potassium salt. 22. The composition of claim 20, wherein the compound is 2-Hydroxy- 1 -methoxy-4-pentafluoropheny lsulfonamidobenzene. 23. The composition of claim 20, wherein the compound is 2-Hydroxy- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, monosodium salt. 24. The composition of claim 21 , wherein the compound is 2-Fluoro- 1 -methoxy -4-pentafluorophenylsulfonamidobenzene. 25. The composition of claim 21 , wherein the compound is 2-Fluoro-l-methoxy-4-pentafluorophenylsulfonamidobenzene, sodium salt. 26. The composition of claim 21 , wherein the compound is 2-Fluoro- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, potassium salt. 27. The composition of claim 12, wherein R 2 is a trisubstituted phenyl. 28. The composition of claim 21, wherein the compound is 2-Bromo-l-methoxy-4-pentafluorophenylsulfonamidobenzene, or 2-Chloro- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene. 29. The composition of claim 12, wherein the compound is 1 ,2-Dimethyl-4-pentafluorophenylsulfonamidobenzene. 30. The composition of claim 1 , wherein in the compound of formula I, Y is SO 2 and Z is NR'R 2 , where R' is hydrogen or lower alkyl, and R 2 is an unsubstituted or optionally substituted naphthyl group. 31. The composition of claim 30, wherein the compound is 7-Hydroxy-2-pentafluorophenylsulfonamidonaphthalene. 32. The composition of claim 4, wherein R 2 is a phenyl group substituted by phenoxy or optionally substituted phenoxy. 33. The composition of claim 32, wherein the compound is 3-Phenoxy-l-pentafluorophenylsulfonamidobenzene. 34. The composition of claim 3, wherein R 2 is a phenyl ring substituted by a heterocyclic group at the 4- position, in relation to the sulfonamido group. 35. The composition of claim 17, wherein the compound is 4-Methoxy-l-pentafluorophenylsulfonamidobenzene. 36. The composition of claim 2, wherein R' and R 2 are covalently joined in a moiety that forms a 5- or 6- membered heterocyclic ring with the nitrogen atom of NR'R 2 . 37. The composition of claim 36, wherein R' is a -CH=CH- group linked to the 2- position of the R 2 phenyl group, in relation to the sulfonamido group, forming an optionally substituted indole. 38. The composition of claim 37, wherein the compound is 1 -pentafluoropheny lsulfonylindole. 39. The composition of claim 36, wherein R 1 is a -(CH 2 ) 3 - group linked to the 2- position of the R 2 phenyl group, in relation to the sulfonamido group, forming an optionally substituted 1 ,2,3,4-tetrahydroquinoline. 40. The composition of claim 39, wherein the compound is 1 -pentafluorobenzenesulfonyl- 1 ,2,3,4-tetrahydroquinoline. 41. The composition of claim 2, wherein R 1 is an optionally substituted (C2-C10)alkyl or optionally substituted (C2-C6)heteroalkyl. 42. The composition of claim 41 , wherein the compound is 2-Hydroxy-l-methoxy-4-[N-(5-hydroxypent-l-yl)pentafluorophenyl-sulfonamido]benzene, 4-Methoxy- 1 -[N-(2-propenyl)pentafluorophenylsulfonamido]benzene, 4-Methoxy- 1 -[N-(4-penteny l)pentafluorophenylsulfonamido]benzene, l-[N-(2,3-Dihydroxypropyl) pentafluorophenylsulfonamido]- 4-methoxybenzene, l-[N-(3,4-Dihydroxybutyl)pentafluorophenylsulfonamido]- 4-methoxy benzene, l-[N-(4,5-Dihydroxypentyl)pentafluorophenylsulfonamido]- 4-methoxybenzene, 1 -[N-(4-hydroxybutyl)pentafluorophenylsulfonamido]-4-methoxybenzene, or 4-Methoxy- 1 -[N-(5-hydroxypentyl)pentafluorophenylsulfonamido]benzene. 43. A method of treating or preventing a disease state characterized by abnormally high levels of low density lipoprotein particles or cholesterol in the oiood, which method comprises administering to a mammalian subject in need thereof a therapeutically effective amount of a composition containing a compound of formula I or a pharmaceutically acceptable salt thereof, wherein: Y is -S(O)- or -S(O) 2 -; Z is -NR'R 2 or -OR 3 ; where R 1 and R 2 are independently selected from hydrogen, substituted or unsubstituted (Cl-ClO)alkyl, substituted or unsubstituted (C 1 -C 10)alkoxy, substituted or unsubstituted (C3-C6)alkenyl, substituted or unsubstituted (C2-C6)heteroalkyl, substituted or unsubstituted (C3-C6)heteroalkenyl, substituted or unsubstituted (C3-C6)alkynyl, substituted or unsubstituted (C3-C8)cycloalkyl, substituted or unsubstituted (C5-C7)cycloalkenyl, substituted or unsubstituted (C5-C7)cycloalkadienyl, substituted or unsubstituted aryl, substituted or unsubstituted aryloxy, substituted or unsubstituted aryl-(C3-C8)cycloalkyl, substituted or unsubstituted aryl-(C5-C7)cycloalkenyl, substituted or unsubstituted aryloxy-(C3-C8)cycloalkyl, substituted or unsubstituted aryl-(Cl-C4)alkyl, substituted or unsubstituted aryl-(Cl-C4)alkoxy, substituted or unsubstituted aryl-(Cl-C4)heteroalkyI, substituted or unsubstituted aryl-(C3-C6)alkenyl, substituted or unsubstituted aryloxy-(Cl-C4)alkyl, substituted or unsubstituted aryloxy-(C2-C4)heteroalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaryloxy, substituted or unsubstituted heteroaryl-(Cl-C4)alkyl, substituted or unsubstituted heteroaryl-(Cl-C4)alkoxy, substituted or unsubstituted heteroaryl-(Cl-C4)heteroalkyl, substituted or unsubstituted heteroaryl-(C3-C6)alkenyl, substituted or unsubstituted heteroaryloxy-(Cl-C4)alkyl, and substituted or unsubstituted heteroaryloxy-(C2-C4)heteroalkyl, wherein R' and R 2 may be connected by a linking group E to give a substituent of the formula wherein E represents a bond, (C1-C4) alkylene, or (C1-C4) heteroalkylene, and the ring formed by R 1 , E, R 2 and the nitrogen contains no more than 8 atoms; and where R 3 is optionally substituted aryl or optionally substituted heteroaryl. 44. The method of claim 43 wherein, in the compound of formula I, Y is SO 2 and Z is NR'R 2 ; where R 2 is optionally substituted aryl or optionally substituted heteroaryl. 45. The method of claim 44, wherein R 1 is hydrogen or lower alkyl, R 2 is optionally substituted phenyl, and there is no linking group E between R 1 and R 2 . 46. The method of claim 45, wherein R 1 is hydrogen or methyl, and the substituents on R 2 are independently chosen from lower alkyl, hydroxy, lower alkoxy, amino, amino optionally substituted with one or two lower alkyls, optionally substituted arylamino, optionally substituted heteroary lamino, optionally substituted phenoxy, and halogen. 47. The method of claim 46, wherein the compound is chosen from: 4 - ( N ,N - D i met hy l amin o ) - l - p en t afluo ro p hen y ls u lf on amid ob enz e n e, 3 -(N,N-Dimethy lamino)- 1 -pentafluoropheny lsulfonamidobenzene, l,2-Ethylenedioxy-4-pentafluorophenylsulfonamidobenzene, 1 ,2-Methylenedioxy-4-pentafluorophenylsulfonamidobenzene, l,2-Dimethoxy-4-pentafluorophenylsulfonamidobenzene, 2-Hydroxy- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, 2-Fluoro- 1 -methoxy -4-pentafluorophenylsulfonamidobenzene, 4-Methoxy- 1 -pentafluorophenylsulfonamidobenzene, 3 -Hydroxy- 1 -pentafluoropheny lsulfonamidobenzene, 4-Hydroxy- 1 -pentafluoropheny lsulfonamidobenzene, l,2-Dimethyl-4-pentafluorophenylsulfonamidobenzene, 4-(N,N-Diethylamino)- 1 -pentafluoropheny lsulfonamidobenzene, 4- Amino- 1 -pentafluoropheny lsulfonamidobenzene, Pentafluorophenylsulfonamidobenzene, 5-Pentafluorophenylsulfonamidoindazole, 5-Pentafluorophenylsulfonamidoindole, 4-(N,N-Dimethy lamino)- 1 -(N-methy Ipentafluoropheny lsulfonamido)-benzene, 4-(N,N-Dimethylamino)- 1 -(pentafluorophenylsulfonamido)benzene, 1 ,2-Dihydroxy-4-pentafluorophenylsulfonamidobenzene, 4-Ethoxy- 1 -pentafluorobenzenesulfonamidobenzene, 3,5-Dimethoxy-l-pentafluorobenzenesulfonamidobenzene, 3-Ethoxy- 1 -pentafluorobenzenesulfonamidobenzene, 7-Hydroxy-2-pentafluorobenzenesulfonamidonaphthalene, 3-Phenoxy- 1 -pentafluorobenzenesulfonamidobenzene, 3-Methoxy- 1 -pentafluorobenzenesulfonamidobenzene, 4( 1 -Moφholino)- 1 -pentafluorobenzenesulfonamidobenzene, 5-Pentafluoroberιzenesulfonamido-l,2,3-trimethoxybenzene, 2-Hydroxy- 1 ,3-methoxy-5-pentafluorobenzenesulfonamidobenzene, 1 ,2-Dihydroxy-3-methoxy-5-pentafluorobenzenesulfonamidobenzene, 5-Pentafluorobenzenesulfonamido- 1 ,2,3-trihydroxy benzene, l,3-Dimethoxy-2-hydroxy-5-pentafluorobenzenesulfonamidobenzene, l,2-Dihydroxy-3-methoxy-5-pentafluorobenzenesulfonamidobenzene, 5-Pentafluorobenzenesulfonamido- 1 ,2,3-trihydroxybenzene, 3-Hydroxy-5-methoxy- 1 -pentafluorobenzenesulfonamidobenzene, 3 ,5-Dihydroxy- 1 -pentafluorobenzenesulfonamidobenzene, 2-Fluoro- 1 -methoxy -4-(N-methylpentafluorophenylsulfonamido)benzene, 2-Bromo- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, 2-Chloro- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, 4-(N,N-Dimethylamino)- 1 -pentafluorophenylsulfonamidobenzene hydrochloride, 3 ,4-Difluoro- 1 -pentafluorobenzenesulfonamidobenzene, 4-Trifluoromethoxy- 1 -pentafluorobenzenesulfonamidobenzene, 2-Chloro-5-pentafluorophenylsulfonamidopyridine, 2-Hydroxy-l-methoxy-4-[N-(5-hydroxypentyl)pentafluorophenylsulfonamido]benzene, 4-( 1 , 1 -Dimethyl)ethoxy- 1 -pentafluorophenylsulfonamidobenzene, 2-Bromo-3-hydroxy-4-methoxy- 1 -pentafluorobenzenesulfonamido-benzene, 2-Bromo-4-methoxy-5-hydroxy- 1 -pentafluorobenzenesulfonamido-benzene, l-Bromo-4-fluoro-5-methoxy-2-pentafluorophenylsulfonamidobenzene, 2-Hydroxy-l-methoxy-4-pentafluorobenzenesulfonamidobenzene; sodium salt, 2-Hydroxy- 1 -methoxy-4-pentafluorobenzenesulfonamidobenzene; potassium salt, 2-Fluoro- 1 -methoxy-4-pentafluorobenzenesulfonamidobenzene; sodium salt, 2-Fluoro-l-methoxy-4-pentafluorobenzenesulfonamidobenzene; potassium salt, 3 -Chloro- 1 -pentafluorophenylsulfonamidobenzene, 4-Chloro- 1 -pentafluorophenylsulfonamidobenzene, 3 -Nitro- 1 -pentafluorophenylsulfonamidobenzene, 4-Methoxy- 1 -pentafluorophenylsulfonamido-3 -trifluoromethyl benzene, 4-Methoxy- 1 -(N-(2-propenyl)pentafluorophenylsulfonamido)benzene, 1 -(N-(3 -Butenyl)pentafluorophenylsulfonamido)-4-methoxybenzene, 4-Methoxy- 1 -(N-(4-pentenyl)pentafluorophenylsulfonamido)benzene, l-(N-(2,3-Dihydroxypropyl)pentafluorophenylsulfonamido)-4-methoxybenzene, 1 -(N-(3 ,4-Dihydroxybutyl)pentafluorophenylsulfonamido)-4-methoxybenzene, l-(N-(4,5-Dihydroxypentyl)pentafluorophenylsulfonamido)-4-methoxy benzene, l-(N-(4-hydroxybutyl)pentafluorophenylsulfonamido)-4-methoxybenzene, 4-Methoxy-l-(N-(5-hydroxypentyl)pentafluorophenylsulfonamido)-benzene, 4-Methoxy-3 -nitro- 1 -pentafluorophenylsulfonamidobenzene, 3-Amino-4-methoxy- 1 -pentafluorophenylsulfonamidobenzene, 4-Butoxy- 1 -pentafluorophenylsulfonamidobenzene, l-Pentafluorophenylsulfonamido-4-phenoxy benzene, 4-Benzy loxy- 1 -pentafluorophenylsulfonamidobenzene, 4-Methylmercapto- 1 -pentafluorophenylsulfonamidobenzene, 2-Methoxy- 1 -pentafluorophenylsulfonamidobenzene, 4- Ally loxy- 1 -pentafluorophenylsulfonamidobenzene, l-Pentafluorophenylsulfonamido-4-propoxybenzene, 4-( 1 -Methy l)ethoxy- 1 -pentafluoropheny lsulfonamidobenzene, 1-Pentafluorobenzenesulfonyloxy benzene, 1 -Pentafluorobenzenesulfonylindole, 1 -Pentafluorobenzenesulfonyl- 1 ,2,3,4-tetrahydroquinoline, 2-Methoxy-5-pentafluorophenylsulfonamidopyridine, 2-Fluoro- 1 -methoxy-4-pentafluorophenylsulfinamide, 4-ter/-Butoxy- 1 -pentafluorophenylsulfonamidobenzene, and 2 - Anilino-3 -pentafluoropheny lsulfonamidopy ridine . 48. The method of claim 47, wherein the compound is chosen from: 4-(N,N-Dimethylamino)- 1 -pentafluorophenylsulfonamidobenzene, 3 -(N,N-Dimethy lamino)- 1 -pentafluorophenylsulfonamidobenzene, l,2-Ethylenedioxy-4-pentafluorophenylsulfonamidobenzene, 2-Hydroxy- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, 2-Fluoro- 1 -methoxy -4-pentafluorophenylsulfonamidobenzene, 4-Methoxy- 1 -pentafluorophenylsulfonamidobenzene, 3 -Hydroxy- 1 -pentafluoropheny lsulfonamidobenzene, 4-Hydroxy- 1 -pentafluorosulfonamidobenzene, 1 ,2-DimethyI-4-pentafluoropheny lsulfonamidobenzene, 5-Pentafluorophenylsulfonamidoindole, 4-(N,N-Dimethylamino)-l-(N-methylpentafluorophenylsulfonamido)-benzene, 4-Ethoxy- 1 -pentafluorobenzenesulfonamidobenzene, 3 -Methoxy- 1 -pentafluorobenzenesulfonamidobenzene, 2-Bromo- 1 -medιoxy-4-pentafluorophenylsulfonamidobenzene, 2-Chloro- 1 -medιoxy-4-pentafluorophenylsulfonamidobenzene, 2-Bromo-3-hydroxy-4-methoxy- 1 -pentafluorobenzenesulfonamido-benzene, 2-Bromo-4-methoxy-5-hydroxy- 1 -pentafluorobenzenesulfonamido-benzene, l-Bromo-4-fluoro-5-methoxy-2-pentafluorophenylsulfonamidobenzene, 2-Hydroxy- 1 -methoxy-4-pentafluorobenzenesulfonamidobenzene; monosodium salt, 2-Hydroxy-l-methoxy-4-pentafluorobenzenesulfonamidobenzene; monopotassium salt, 2-Fluoro-l-methoxy-4-pentafluorobenzenesulfonamidobenzene; sodium salt, 2-Fluoro- 1 -memoxy-4-pentafluorobenzenesulfonamidobenzene; potassium salt, 4-Chloro- 1 -pentafluorophenylsulfonamidobenzene, and 3-Amino-4-methoxy- 1 -pentafluoropheny lsulfonamidobenzene. 49. The method of claim 48, wherein the compound is: 2-Hydroxy- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, 2-Fluoro- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, 4-Methoxy- 1 -pentafluoropheny lsulfonamidobenzene, 1 ,2-Dimethyl-4-pentafluorophenylsulfonamidobenzene, 5-Pentafluorophenylsulfonamidoindole, 4-Ethoxy- 1 -pentafluorobenzenesulfonamidobenzene, 2-Bromo- 1 -methoxy-4-pentafluorophenylsuIfonamidobenzene, 2-Chloro- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, 2-Bromo-3-hydroxy-4-methoxy-l-pentafluorobenzenesulfonamido-benzene, 2-Bromo-4-methoxy-5-hydroxy- 1 -pentafluorobenzenesulfonamido-benzene, l-Bromo-4-fluoro-5-methoxy-2-pentafluorophenylsulfonamidobenzene, 2-Hydroxy- 1 -methoxy-4-pentafluorobenzenesulfonamidobenzene; monosodium salt, 2-Hydroxy- 1 -methoxy-4-pentafluorobenzenesulfonamidobenzene; monopotassium salt, 2-Fluoro- 1 -methoxy-4-pentafluorobenzenesulfonamidobenzene; sodium salt, 2-Fluoro-l-methoxy-4-pentafluorobenzenesulfonamidobenzene; potassium salt, or 3-Amino-4-methoxy- 1 -pentafluorophenylsulfonamidobenzene. 50. The method of claim 49, wherein the compound is 2-Hydroxy- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, 2-Hydroxy- 1 -methoxy -4-pentafluorobenzenesulfonamidobenzene; monosodium salt, or 2-Hydroxy- 1 -methoxy-4-pentafluorobenzenesulfonamidobenzene; monopotassium salt. 51. The method of claim 49, wherein the compound is 2-Fluoro- 1 -methoxy-4-pentafluorobenzenesulfonamidobenzene. 52. The method of claim 49, wherein the compound is 2-Fluoro- 1 -methoxy-4-pentafluorobenzenesulfonamidobenzene, sodium salt. 53. The method of claim 49, wherein the compound is 2-Fluoro- 1 -methoxy-4-pentafluorobenzenesulfonamidobenzene, potassium salt. 54. The method of claim 43 wherein the disease state is atherosclerosis. 55. The method of claim 43 wherein the disease state is pancreatitis. 56. The method of claim 43 wherein the disease state is hypercholesterolemia. 57. The method of claim 43 wherein the disease state is hyperlipoproteinemia. 58. The method of claim 43 wherein the composition is administered orally. 59. The method of claim 43 wherein the subject is human. 60. The method of claim 43 wherein the composition is administered in combination with a therapeutically effective amount of a hypolipemic agent or a hypocholesterolemic agent that is not represented by formula I. 61. A compound having the formula I : or a pharmaceutically acceptable salt thereof, wherein: Y is -S(O)- or -S(O 2 )-; and Z is NR'R 2 , wherein R 2 is an optionally substituted aryl or heteroaryl group, and R 1 is selected from hydrogen, substituted or unsubstituted (Cl-ClO)alkyl, substituted or unsubstituted (C 1 -C 10)alkoxy, substituted or unsubstituted (C3-C6)alkenyl, substituted or unsubstituted (C2-C6)heteroalkyl, substituted or unsubstituted (C3-C6)heteroalkenyl, substituted or unsubstituted (C3-C6)alkynyl, substituted or unsubstituted (C3-C8)cycloalkyl, substituted or unsubstituted (C5-C7)cycloalkenyl, substituted or unsubstituted (C5-C7)cycloalkadienyl, substituted or unsubstituted aryl, substituted or unsubstituted aryloxy, substituted or unsubstituted aryl-(C3-C8)cycloalkyl, substituted or unsubstituted aryl-(C5-C7)cycloalkenyl, substituted or unsubstituted aryloxy-(C3-C8)cycloalkyl, substituted or unsubstituted aryl-(Cl-C4)alkyl, substituted or unsubstituted aryl-(Cl-C4)alkoxy, substituted or unsubstituted aryl-(C 1 -C4)heteroalky 1, substituted or unsubstituted aryl-(C3-C6)alkenyl, substituted or unsubstituted aryloxy-(Cl-C4)alkyl, substituted or unsubstituted aryloxy-(C2-C4)heteroaikyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaryloxy, substituted or unsubstituted heteroaryl-(Cl-C4)alkyl, substituted or unsubstituted heteroaryl-(Cl-C4)alkoxy, substituted or unsubstituted heteroaryl-(Cl-C4)heteroalkyl, substituted or unsubstituted heteroaryl-(C3-C6)alkenyI, substituted or unsubstituted heteroaryloxy-(Cl-C4)alkyl, and substituted or unsubstituted heteroaryloxy-(C2-C4)heteroalkyl, wherein R l and R 2 may be connected by a linking group E to give a substituent of the formula wherein E represents a bond, (C1-C4) alkylene, or (C1-C4) heteroalkylene, and the ring formed by R', E, R 2 and the nitrogen contains no more than 8 atoms; provided that: in the case that Y is -S(O 2 )-, and R 1 is hydrogen or methyl, then R 2 is substituted phenyl or heteroaryl group; in the case that Y is -S(O 2 )- and R 2 is a ring system chosen from 1 -naphthyl, 5- quinolyl, or 4-pyridyl, then either R ' is not hydrogen or R 2 is substituted by at least one substituent that is not hydrogen; in the case that Y is -S(O 2 )-, R 2 is phenyl, and R ' is a propylene unit attaching the nitrogen of -NR'R 2 - to the 2- position of the phenyl ring in relation to the sulfonamido group to form a 1,2,3,4-tetrahydroquinoline system, and one or more of the remaining valences on the bicyclic system so formed is substituted with at least one substituent that is not hydrogen; in the case that Y is -S(O 2 )- and R 2 is phenyl substituted with 3-(l-hydroxyethyl), 3-dimethylamino, 4-dimemylamino, 4-phenyl, 3-hydroxy, 3 -hydroxy -4-diethylaminomethyl, 3,4-methylenedioxy, 3,4-ethylenedioxy, 2-(l-pyrrolyl), or 2-methoxy-4-(l-moφholino), then either R 1 is not hydrogen or when R 1 is hydrogen, one or more of the remaining valences on the phenyl ring of R 2 is substituted with a substituent diat is not hydrogen; in the case that Y is -S(O 2 )- and R 2 is 2-methylbenzothiazol-5-yl, 6 -hy droxy -4 -met hy l-p y rimi d in- 2 - y l , 3 - c arb o met ho xy py raz in- 2- y l , 5-carbomethoxypyrazin-2-yl, 4-carboethoxy-l -phenylpyrazol-5-yl, 3-methylpyrazol-5-yl, 4-chloro-2-methylthiopyrimidin-6-yl, 2-trifluoromethyl-l ,3,4-thiadiazol-5-yl, 5,6,7,8- tetrahydro-2-naphthyl, 4-methylthiazol-2-yl, 6,7-dihydroindan-5-yl, 7-chloro-5-methyl-l,8- naphthyridin-2-yl, 5,7-dimethyl-l,8-naphthyridin-2-yl, or 3-cyanopyrazol-4-yl, then R' is a group other than hydrogen; wherein said compound has pharmacological activity. 62. The compound of claim 61, wherein R 1 is hydrogen or lower alkyl, Y is S(O 2 ), and there is no linking group E between R 1 and R 2 . 63. The compound of claim 62, wherein R 1 is hydrogen or methyl and R 2 is substituted phenyl, wherein the substituents on R 2 , ranging in number from one to four, are independently chosen from lower alkyl, hydroxy, lower alkoxy, amino optionally substituted with one or two lower alkyls, optionally substituted arylamino, optionally substituted heteroarylamino, optionally substituted phenoxy, and halogen. 64. The compound of claim 63, wherein R 1 is hydrogen and R 2 is substituted phenyl, wherein die substituents on R 2 are independently chosen from amino, (lower)alkylamino, and di(lower)alkylamino, and are located at one or more of positions 3- and 4- of the phenyl ring, in relation to the sulfonamido group. 65. The compound of claim 64, wherein the compound is 4-(N,N-Diethy lamino)- 1 -pentafluorophenylsulfonamidobenzene, or 4-Amino- 1 -pentafluorophenylsulfonamidobenzene. 66. The compound of claim 62, wherein R ' is hydrogen, and R 2 is phenyl substituted at positions 3- and 4-, in relation to the sulfonamido group, with a divalent moiety that forms a 5- or 6- membered ring togemer wim carbons 3- and 4- of the phenyl ring. 67. The compound of claim 66, wherein the divalent moiety is: -C=CNH-, or -C=NNH-. 68. The compound of claim 67, wherein the compound is 5- Pentafluorophenylsulfonamidoindazole or 5 -Pentafluoropheny lsulfonamidoindole. 69. The compound of claim 63, wherein R 1 is hydrogen, and the substituents on R 2 are independently selected from halogen, hydroxy, lower alkyl, lower alkoxy, amino, (lower)alkylamino, and di(lower)alkylamino. 70. The compound of claim 69, wherein the substituents on R 2 are independently selected from bromo, chloro, fluoro, hydroxy, methoxy, ethoxy, amino, or dimethylamino. 71. The compound of claim 70, wherein the substituents on R 2 are independently selected from bromo, chloro, fluoro, hydroxy, methoxy, and ethoxy. 72. The compound of claim 71, wherein the substituents on R 2 are at one or more of positions 3- and 4- of the phenyl ring, in relation to the sulfonamido group. 73. The compound of claim 72, wherein R 2 is monosubstituted phenyl. 74. The compound of claim 73, wherein the compound is 4-Methoxy- 1 -pentafluorophenylsulfonamidobenzene, 3 -Hydroxy- 1 -pentafluoropheny lsulfonamidobenzene, 4-Hydroxy- 1 -pentafluorophenylsulfonamidobenzene, 4-Emoxy- 1 -pentafluoropheny lsulfonamidobenzene, 3-Ethoxy-l -pentafluorophenylsulfonamidobenzene, or 3-Methoxy- 1 -pentafluorophenylsulfonamidobenzene. 75. The compound of claim 73, wherein the compound is 3 -Chloro- 1 -pentafluoropheny lsulfonamidobenzene, or 4-Chloro- 1 -pentafluorophenylsulfonamidobenzene. 76. The compound of claim 72, wherein R 2 is disubstituted phenyl. 77. The compound of claim 76, wherein the compound is l,2-Dimethoxy-4-pentafluorophenylsulfonamidobenzene, 2-Hydroxy- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, l,2-Dihydroxy-4-pentafluorophenylsulfonamidobenzene, 2-Hydroxy-l-methoxy-4-pentafluorophenylsulfonamidobenzene, monosodium salt, or 2-Hydroxy-l -methoxy -4-pentafluoropheny lsulfonamidobenzene, monopotassium salt. 78. The compound of claim 76, wherein the compound is 2-Fluoro- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, 2-Bromo- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, 2-Chloro- 1 -methoxy -4-pentafluoropheny lsulfonamidobenzene, 2-Fluoro-l-methoxy-4-pentafluorophenylsulfonamidobenzene, sodium salt, or 2-Fluoro- 1 -methoxy-4-pentafluoropheny lsulfonamidobenzene, potassium salt. 79. The compound of claim 77, wherein the compound is 2-Hydroxy-l-methoxy-4-pentafluorophenylsulfonamidobenzene, or 2-Hydroxy- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene, monosodium salt. 80. The compound of claim 78, wherein the compound is 2-Fluoro- 1 -methoxy -4-pentafluoropheny lsulfonamidobenzene, or 2 -Fluoro- 1 -methoxy -4-pentafluoropheny lsulfonamidobenzene, sodium salt. 81. The compound of claim 80, wherein the compound is 2-Fluoro- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene. 82. The compound of claim 80, wherein the compound is 2-Fluoro-l -methoxy -4-pentafluoropheny lsulfonamidobenzene, sodium salt. 83. The compound of claim 72, wherein R 2 is trisubstituted phenyl. 84. The compound of claim 78, wherein the compound is 2 - B ro m o - 1 - met hoxy - 4 -p ent afluo rop h eny ls ul fo namid o benz ene , o r 2-Chloro- 1 -methoxy-4-pentafluorophenylsulfonamidobenzene. 85. The compound of claim 69, wherein the compound is l,2-Dimethyl-4-pentafluorophenylsulfonamidobenzene. 86. The compound of claim 63 , wherein the compound is 3 -Phenoxy- 1 -pentafluorophenylsulfonamidobenzene. 87. The compound of claim 62, wherein R 2 is a phenyl ring substituted by a heterocyclic group at the 4- position, in relation to the sulfonamido group. 88. The compound of claim 74, wherein the compound is 4-Methoxy- 1 -pentafluorophenylsulfonamidobenzene. 89. The compound of claim 61, wherein R 1 and R 2 are covalently joined in a moiety that forms a 5- or 6- membered heterocyclic ring with the nitrogen atom of NR'R 2 . 90. The compound of claim 89, wherein R' is a -CH=CH- group linked to the 2- position of the R 2 phenyl group, in relation to the sulfonamido group, forming an optionally substituted indole. 91. The compound of claim 90, wherein the compound is l-(PentafluorophenylsulfonyI)indole. 92. The compound of claim 89, wherein R 1 is a -(CH 2 ) 3 - group linked to the 2- position of the R 2 phenyl group, in relation to the sulfonamido group, forming an optionally substituted 1 ,2,3,4-tetrahydroquinoline. 93. The compound of claim 61 , wherein the compound is 2-Hydroxy- 1 -methoxy -4-[N-(5-hydroxypent- 1 -y l)pentafluorophenyl-sulfonamido]benzene, 4-Methoxy- 1 -[N-(2-propenyl)pentafluorophenylsulfonamido]benzene, 4-Methoxy- 1 - [N-(4-penteny ipentafluoropheny lsulfonamidojbenzene, 1 -[N-(2,3-Dihydroxypropyl) pentafluorophenylsulfonamido]- 4-methoxybenzene, l-[N-(3,4-Dihydroxybutyl)pentafluorophenylsulfonamido]- 4-methoxybenzene, l-[N-(4,5-Dihydroxypentyl)pentafluorophenylsulfonamido]- 4-memoxybenzene, 1 -[N-(4-hydroxybutyl)pentafluorophenylsulfonamido]-4-methoxybenzene, or 4-Methoxy-l-[N-(5-hydroxypentyl)pentafluorophenylsulfonamido]benzene. 94. The composition of any of claim 1 -42, or a method of any of claim 43-60, or a compound of any of claim 61-93, wherein the compound regulates LDL receptor gene expression.

Inventors: CLARK DAVID, FLYGARE JOHN, MEDINA JULIO C, ROSEN TERRY, SHAN BEI, CLARK, DAVID, FLYGARE, JOHN, MEDINA, JULIO, C., ROSEN, TERRY, SHAN, BEI
Applicants: TULARIK INC, TULARIK, INC.
Application year: 1997
Main classification: A61K
IPC codes: A61K31, A61P1, A61P3, A61P9, C07C309, C07C311, C07C323, C07D209, C07D213, C07D231, C07D295, C07D317, C07D319