COMPOSITIONS FOR DISINFECTION OF SKIN AND MUCOUS MEMBRANE

Abstract: The invention relates to process and compositions for disinfecting the skin, hands and mucous membrane, which contain an optical brightener. The compositions exhibit intense fluorescence in the visible wavelength range on exposure to UV light and thus permit simple monitoring of the treated skin or mucous membrane surfaces for ensuring complete disinfection, but without exhibiting the disadvantages associated with the use of conventional dyes, such a s discoloration of the skin and articles.

Description: COMPOSITIONS FOR DISINFECTION OF SKIN AND MUCOUS MEMBRANE The invention relates to compositions, containing optical brighteners, such as compositions for disinfecting the hands, skin and mucous membrane. Before operations, the skin or mucous membrane in the region of the operation area is treated with antiseptic disinfectants. Here, it is necessary to ensure complete wetting of the epithelium in order to guarantee complete disinfection. For this reason, intensely coloured preparations which permit visual monitoring of the application of the disinfectant are usually used for disinfecting the skin and mucous membrane. However, the disadvantage of these compositions is that colour changes of the skin which may occur during the operation, such as, for example, pallor as a result of depletion of blood or a blue colour due to inadequate oxygen saturation of the blood, for example in cardiac insufficiency or pulmonary diseases, are masked by the dye, and any necessary measures on the part of the surgeon are thus delayed or even completely prevented. In addition, the pronounced adhesion of the dyes to the skin, in particular of patients, is found to be very troublesome. Moreover, clothing, operating tables, floors, equipment, etc. soiled by the dyes used are difficult to clean. It is the object of the present invention to provide a process for disinfecting a surface which do not have the abovementioned disadvantages by the application of a composition on said surface or mucous membrane surface, in order to be able to ensure complete disinfection of the operating area. This object is achieved by compositions which contain at least one optical brightener. Optical brighteners are compounds which are caused to fluoresce in the visible wavelength range by ultraviolet radiation, i.e. substances which absorb ultraviolet radiation and emit longer-wavelength, visible radiation. Preferably used optical brighteners are the same substances which are also used in detergents for brightening the laundry or in various personal hygiene preparations for increasing the brilliance of, for example, soaps and cosmetic formulations. Particularly preferred optical brighteners are stilbene compounds, such as, for example, diaminos ti lbene- disulphomc acid, coumann derivatives, such as, for example, 4- methyl-7-dιethylamιnocoumann, 1, 3-dιaryldιpyrazolme derivatives, such as, for example, 1, 3-dιphenyl-4-methyl-5- alkylpyrazolme, naphthalimide derivatives, such as, for example, N-methyl-4-methoxynaphthalιmιde, and benzoxazole derivatives, such as, for example, 1, 2-bιs (5 -methylbenzoxazol-2- yl) ethylene. Pyrazolme deπva-tives (e.g. Hostalux* PN, from Hoechst) , cationic benzimidazole derivatives (e.g. BLankophor ® ACR, from Bayer) and anionic dis tearylbiphenyl derivatives (e.g. Blankophor VPSP 20006, from Bayer) are very particularly preferred. Particularly suitable are of course those optical brighteners which are used for brightening wool, such as, for example, Blankophor ACR and Blankophor '® VPSP, since this natural fibre has considerable similarity with human skin. However, brighteners for other fibres, such as, for example, polyamide, paper, polyester, polyacrylom t rile and cotton, are also suitable. The use of optical brighteners permits the preparation of disinfectants which contain a very much lower dye concentration and preferably no customary dyes at all. In contrast to the conventional, intensely coloured disinfectants, they are therefore also suitable for disinfecting the hands as well as equipment and work surfaces, providing for the first time a possibility for monitoring the completeness of wetting m these areas too. The excitation wavelength for the disinfectants according to the invention depends on the optical brightener used and is preferably m the range of customary UV lamps, i.e. preferably in the range from about 300 to 400 nm. Skin surfaces treated with the disinfectants according to the invention therefore fluoresce brightly on exposure to a UV lamp, permitting simple monitoring of the surfaces treated with the compositions and hence guaranteeing complete disinfection of the desired surface. In normal daylight, the disinfectants according to the invention and hence also the treated skin areas and all other articles, such as clothing, floors and equipment, which have come into contact with the compositions are not coloured. A particular advantage of the optical brighteners used according to the invention is that, in contrast to many traditional dyes, they are not absorbed, therefore do not have systemic activity and are hence toxicologically safe. Furthermore, they have no sensitizing properties. The optical brighteners are used in an amount such that, on exposure to UV light of a suitable wavelength, a clear distinction between treated and untreated surfaces is possible. For this purpose, the brighteners are typically used in an amount of from 0.0001 to 3 % by weight, preferably in an amount of from 0.001 to 2.0% by weight, based on the total amount of disinfectant. The concentration of the brightener furthermore depends on the intended use of the composition. While washing hand disinfectants frequently require higher concentrations, for example in the range from 0.2 to 1.0% by weight, since these compositions are for the most part rinsed off again after use, lower concentrations of from 0.005 to 0.5% by weight and in particular from 0.05 to 0.3% by weight may be entirely sufficient in the case of other compositions. The disinfectants according to the invention contain, as further components, conventional constituents such as antimicrobial active ingredients, liquid carriers and excipients. Suitable compositions are known from the prior art. antimicrobical active ingredients include, quaternary compounds, guanidine derivatives, phenol derivatives iodine- eliminating compounds, aromatics alcohols, aliphatic alcohols, peroxyde compounds such as hydrogene peroxyde or organic peroxyacid compounds such as peracetic acid. excipients include anionic surfactants, cationic surfactants or non-ionic surfactants such as alkylether sulfates, alkylbenzene sulfonates, alkylsulfates , fatty acid esters, fattyacid alcohols, polyalkoxylated derivatives of fatty alcohols or of fatty acids, alkylpolyglycosides , betaines, sultalne, imidazoline and their derivatives, and fatty quaternary amonium salts. excipients also include thickening agents. Compositions for disinfecting the skin and mucous membrane preferably contain one or more of the following constituents: Antimicrobial active ingredients - Quaternary compounds from 0.005 to 50% by weight; - Guanidine derivatives from 0.1 to 10% by weight; - Phenol derivatives from 0.02 to 5 % by weight; - Iodine-eliminating from 0.5 to 20% compounds by weight; - Peroxide compounds from 0.001 to 10 by weight; - Aromatic alcohols from 0 5 to 5 % by weight and/or from 1 to 15 % - Alcohols by weight. Excipients Surfactants (preferably cocamidopropylbetaine, sulphosuccinate, sodium lauryl ether sulphate) and/or Stabilizers (preferably H0 2 , buffer substances). Compositions for disinfecting the skin preferably contain one or more of the following constituents: Antimicrobial active ingredients - Alcohols from 5 to 96% by weight; - Quartenary compounds from 0.05 to 50% by weight; - Guanidine derivatives from 0.1 to 10% by weight; - Phenol derivatives from 0.01 to 10% by wei ght; - Iodine-eliminating compounds from 0.5 to 20% by weight; - Peroxide compounds from 0.001 to 10% by weight; - Aromatic alcohols from 0.5 to 10% by weight; - Fatty acids from 0.1 to 5 % by weight and/or from 0.1 to 5 % - Hydroxy carboxylic acids by weight. Excipients Stabilizers (preferably H 2 0 2 ) . Compositions for disinfecting the hands preferably contain one or more of the following constituents: Antimicrobial active ingredients - Alcohols from 5 to 96% by weight; - Quaternary compounds from 0.05 to 50 % by weight; - Guanidine derivatives from 0.1 to 10% by weight; - Phenol derivatives from 0.01 to 10% by weight; - Peroxide compounds from 0.001 to 10% by weight; - Aromatic alcohols from 0.5 to 10% by weight; - Fatty acids from 0.1 to 5 % by weight and/or - Hydroxy carboxylic acids from 0.1 to 5 % by weight. Excipients Superfatting agents (preferably triglycerides, fatty alcohols, fatty acids), Humectants (preferably sorbitol solution, 1, 2-propylene glycol, PEG derivatives, sodium lactate) Thickeners (preferably hydroxyethylcellulose, hydroxy-propyl- cellulose, xanthans , polyacrylates ) Perfume and/or Dyes . Washing hand disinfectants preferably contain one or more of the following constituents: Antimicrobial active ingredients - Alcohols from 5 to 30% by weight; - Quaternary compounds from 0.1 to 20% by weight; - Guanidine derivatives from 0.1 to 10% by weight; - Phenol derivatives from 0.5 to 5 % by weight; - Iodine-eliminating from 0.5 to 20% compounds by weight; - Peroxide compounds from 0.001 to 10 by weight and/or - Aromatic alcohols from 0.5 to 10% by weight. Excipients Surfactants (preferably cocamidopropylbetaine, sulpho-succinate, sodium lauryl ether sulphate) Stabilizers (preferably H 2 0 2 ) Thickeners (preferably hydroxyethylcellulos e) Dyes and/or Perfume. Preferred antimicrobial active ingredients are: Quaternary compounds: Octenidine dihydrochloride, benzalkonium chloride; Guanidine derivatives: Chlorhexidine dihydrochloride; chlorhexidine digluconate; Phenol derivatives: 2- BLphenylol; Iodine-eliminating compounds: Polyvinylpyrrolidone- iodine (PVP-iodine) ; Peroxide compounds: H 2 0 2 ; Aromatic alcohols: Phenoxyethanol, phenethyl alcohol, benzyl alcohol; Alcohols: Ethanol, 1-propanol, 2- propanol; Hydroxycarboxylic acids: Lactic acid; Fatty acids: Undecylenic acid. Compositions as herebefore described, are also an object of the present invention. The invention is illustrated in more detail below with reference to embodiments. Examples Example 1 : Composition for disinfecting the skin and mucous membrane A composition containing the following constituents is prepared as the composition for disinfecting the skin and mucous membrane: Octenidine dihydrochloride 0.10% by weight Phenoxyethanol 2.00% by weight Blankophor ® ACR 0.2% by weight Cocamidopropylbetaine solution 30% 2.00% by weight Sodium gluconate 1.00% by weight Water to make up to 100% Phenoxyethanol is initially introduced into a first vessel and octenidine dihydrochloride is dissolved therein. In a second vessel, sodium gluconate is added to water and stirred until the sodium gluconate has completely dissolved. Thereafter, the cocamidopropylbetaine solution is added and stirred in. The two solutions are then combined and are stirred until a clear solution is obtained. Finally, Hostalux ® PN liquid is added and stirring is carried out again until a clear solution is obtained. Example 2: Composition for disinfecting the hands A composition containing the following constituents is prepared as the composition for disinfecting the hands: Ethyl alcohol 80.00% by weight Isopropyl myristate 1.00% by weight Sorbitol solution 0.50% by weight Hostalux PN liquid (dispersion of a pyrazoline derivative) 0.1% by weight Perfume 0.05% by weight Water to make up to 100% Ethanol and water are mixed, sorbitol solution is added and stirring is carried out. Thereafter, isopropyl myristate and perfume are added and the mixture is stirred until a clear solution is obtained. Hostalux ® PN liquid is then added and stirring is carried out again until a clear solution is obtained. Example 3: Composition for disinfecting the skin A composition containing the following constituents is prepared as the composition for disinfecting the skin: Isopropyl alcohol 45.00% by weight 1-Propanol 10.00% by weight Hostalux ® PN liquid (dispersion of a pyrazoline derivative) 0.1 % by weight Water to make up to 100% Isopropyl alcohol, 1-propanol and water are mixed, Hostalux PN liquid is added and stirring is carried out until a clear solution is obtained. Example 4: Washing hand disinfectant A composition containing the following constituents is prepared as the washing composition for disinfecting the hands: 1-Propanol 10.00% by weight Isopropyl alcohol 8.00% by weight 2- BLphenylol 2.00% by weight Cocamidopropylbetaine 20.00% by weight solution 30% Hostalux ® PN liquid 0.50% by weight (dispersion of a pyrazoline derivative) Pe fume 0.20% by weight Hydroxyethylcellulos e 1.00% by weight Water to make up to 100% Isopropyl alcohol and 1-propanol are mixed, and the hydroxyethylcellulos e is added with stirring. Thereafter, water is added to the mixture and 2-biphenylol, cocamidopropylbetaine solution and perfume are stirred into the mixture in the stated (ft order. Hostalux PN liquid is then added and stirring is carried out until a clear solution is obtained. All mixtures show intense fluorescence on exposure to UV light having a wavelength of 366 nm (UV lamp: CAMAG Reprostar II or DESAGA Heidelberg UVI S universal unit).

Claims: Claims 1. Process for disinfecting a surface by the application of a composition on said surface caracterized m that the composition contains at least an optical brightener. 2. Process according to claim 1 wherein the optical brightener contained by the composition is selected from stilbene compounds, such as diaminos tilbenedisulfomc acid, coumarin derivatives, such as 4-methyl-7-dιethyl aminocoumarm, 1-3-dιarylpyrazolme derivatives, such as 1, 3-dιphenyl-4-methyl- 5alkylpyrazolme, naphthalimide derivatives such as N-methyl-4- methoxy-naphthalimide, and benzoxazole derivatives such as 1,2- bis (5-methylbenzoxazol-2-yl) ethylene. 3. Process accorαmg to anyone of claims 1 to 2, wherein the composition further contains one or more antimicrobial active ingredients selected from quaternary compounds, guanidine derivatives, iodine eliminating compounds, peroxyde compounds aromatic alcohols, non aromatics alcohols, fatty acids, hydroxy carboxylic acids, phenol derivatives or organic peroxyacid compounds such as peracetic acid. 4. Process according to anyone of claims 1 to 3, wherein the composition further contains one or more excipients such as surfactants, humectants, thickeners, perfumer superfattmg agents or dyes. 5. Process according to anyone of claims 1 to 4, wherein the composition further contains one or more stabilizers. 6. Process according to claim 3, wherein the composition contains between 0,1 and 1 by weight of octenidine dihydrochloride. 7. Process according to anyone of claim 1 to claim 6 wherein the surface to be disinfected is a skin surface or a mucous surface. 8. Process according to anyone of claim 1 to 6 wherein the surface to be disinfected is equipment and/or work surfaces of an operating-room. 9. Process according to anyone claim 1 to 6 for disinfecting the hands. 10. Process according to anyone of claim 1 to 9 wherein the composition contains from 0,0001 % to 3,0 % by weight of optical brightener. 11. Process according to claim 10 wherein the composition contains from 0,001 % to 2 % by weight of optical brightener. 12. Composition as defined in anyone of claims 1 to 6. 13. Composition as defined in anyone of claims 10 or 11.

Inventors: BEHRENDS SABINE, HARKE HANS-PETER, BEHRENDS, SABINE, HARKE, HANS-PETER
Applicants: AIR LIQUIDE SANTE DEV SA, BEHRENDS SABINE, HARKE HANS PETER, AIR LIQUIDE SANTE DEVELOPPEMENT, BEHRENDS, SABINE, HARKE, HANS-PETER
Application year: 1997
Main classification: C11D3
IPC codes: A01N25, A01N61, A61K8, A61K47, A61L2, A61Q19, C11D3