OXA ACIDS AND RELATED COMPOUNDS FOR TREATING SKIN CONDITIONS

Abstract: The present invention is directed to the use of compounds of formula (I), depicted above, as active principals for treating skin conditions; compositions containing these compounds; and methods of treating skin conditions using these compounds and compositions. In said formula (I), R4 is (CR5R6-CR7R8-X1)n-CR9R10R11, n is an integer from 1 to 18; R1, R2, R3, R5, R6, R7, R8, R9, R10 and R11 are independently, hydrogen or non-hydrogen substituents; and X, X1, Y and Z are independently O, NH, or S.

Description: OXA ACIDS AND RELATED COMPOUNDS FOR TREATING SKIN CONDITIONS Related Application This application is a continuation-in-part of application Serial No. 08/658,089, filed June 4, 1996, pending. BACKGROUND OF THE INVENTION Field of Invention The present invention relates to a new class of compounds for use as active principals for topical treatment of skin conditions, to compositions containing these compounds and to methods of treating skin conditions using these compounds and compositions, Compounds of the class include those of Formula (I) : wherein, R 4 is (CR 5 R 6 -CR 7 R 8 -Xι) n -CR 9 RιoRιι; n is an integer from 1 to 18; R l r R 2 , R 3 , R 5 , Re, v, RB, R9, Rio and R n , are independently hydrogen or non-hydrogen substituents, with preferred non-hydrogen substituents including alkyls, alkenyls, oxa-alkyls, aralkyls and aryls; and X, Xi, Y and Z are independently, 0, NH or S, with preferred compounds including those in which X, Xx, Y and Z are each oxygen and Ri, R ? , R 3 , R 5 , R 6 , R 7 , R B , 9, Rio and R 1X are each hydrogen. II . Description of the Prior Art Dermal use of alpha hydroxyacids having an all carbon backbone is described in U.S. Patent No. 5,091,171. Cosmetic compositions using 2- hydroxyalkenoic acid are disclosed, for example, in U.S. Patent No. 5,108,751. Such compounds must have an unsubstituted alpha hydoxy group on a carbon backbone and are purportedly used to impart beneficial effects to the skin. However, the trend is away from the use of such alpha hydroxyacids since they necessitate low operational pH ranges that for the most common forms, i.e. glycolic and lactic acids, are known to cause skin irritations . Topical formulations comprising straight, all carbon backbone, dicarboxylic acids have been proposed as replacements for alpha hydroxyacids. For example, U.S. Patent Nos. 4,292,326, 4,386,104 and 5,385,943 describe the use of dicarboxylic acids having 7 to 13 carbon atoms for various skin indications. Similarly, U.S. Patent No. 4,885,282 states that a 4 to 18 carbon dicarboxylic acid compound is useful for the treatment of skin disorders. The problem with the use of these dicarboxylic acids is their inherent insolubility in aqueous solutions. Such solutions make up the majority of cosmetic delivery systems. Also, dicarboxylic acids that have all carbon backbones are solid at ambient temperatures, extremely difficult to work with and, if a solution is achieved, the result is an aesthetically unpleasant mixture unsuitable for cosmetic use. Therefore, there is a need for a compound or class of compounds that can be used as mild, exfoliating actives for topical treatment of skin. There is also a need for a mild, exfoliating topical composition that contains a water soluble compound that can be manufactured into an aesthetically acceptable cosmetic or dermatologic products. SUMMARY OF THE INVENTION It is an object of the present invention to provide a water soluble compound or class of such compounds that can be manufactured into an aesthetically acceptable, mild, exfoliating composition for topical use. It is another object of the present invention to provide topical compositions with such water soluble compounds that have multiple skin care benefits. It is a further object of the present invention to provide a new, dermatologic and cosmetic use for oxa acids . These and other objects will become evident from the following disclosure. DETAILED DESCRIPTION OF THE INVENTION The basic compound of this invention is a compound of the following Formula (I) : wherein, R is (CRsRβ-CR-yRβ-Xi) --CR9R10R11; n is an integer from 1 to 18; R x , R 2 , R 3 , R 5 , R 6 , R , R 8 , R9, Rio and R u are independently hydrogen or non-hydrogen substituents . X, Xi, Y and Z are independently, 0, NH, or S. Preferred are those compounds in which X, Xi, Y and Z are all oxygen. Most preferred are those compounds in which X, Xi, Y and Z are each oxygen, and Ri, R 2 , R 3 , R 5 , Re , R7, Rs, R9, Rio and Rn, are each hydrogen. The preferred non-hydrogen substituents include alkyls alkenyls, oxa-alkyls, aralkyls and aryls. Examples of non-hydrogen substituents include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, hexyl, heptyl, octyl, nonyl, dodecanyl, methoxy, ethoxy, propoxy, butoxy, cyclohexenyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, cyclobutyl and cyclohexanyl . Exemplary compounds of Formula (I) include 3,6- dioxaheptanioic acid (CH 3 -O-CH 2 -CH 2 -O-CH 2 -COOH) ; 7,7- dimethyl-3, 6-dioxaheptanoic acid ( (CH3) 2 CH-0-CH 2 -CH 2 -0- CH 2 -C00H) ; 3, 6-dioxaheptanoic acid ethyl ester (CH 3 -0- CH 2 -CH 2 -0-CH 2 -COOC 2 H 5 ) ; 3, 6-dioxaheptanoic acid amine (CH 3 -O-CH2-CH2-O-CH2-CONH2) ; 3, 6-dioxaheptanoic acid dodecyl ester (CH 3 -0-CH2-CH2-0-CH2-COOC 12 H 2 5) ; 2-phenyl- 3, 6-dioxaheptanoic acid (CH 3 -0-CH 2 -CH 2 -0-CH (Phe) -COOH) ; 2-benzyl-3, 6-dioxaheptanoic acid (CH 3 -0-CH ? -CH 2 -0- CH(CH 2 Phe) -COOH) ; 2-methyl-3, 6-dioxaheptanoic acid (CH 3 -0-CH 2 -CH 2 -0-CH (CH 3 ) -COOH) ; 3-amino-6-oxaheptanoic acid (CH 3 -O-CH 2 -CH 2 -NH-CH2-COOH) ; 3, 6, 9-trioxadecanoic acid (CH 3 -0-CH 2 -CH ? -0-CH 2 -CH 2 -0-CH 2 -COOH) ; 2-phenyl- 3, 6, 9-trιoxadecanoιc acid (CH 2 -0-CH ? -CH 2 -0-CH 2 -CH 2 -0- CH (Phe) -COOH) ; 2-benzyl-3, 6, 9-trιoxadecanoιc acid (CH 3 - O-CH 2 -CH 2 -O-CH 2 -CH2-O-CH (CH 2 -Phe) -COOH) ; 2-decyl-3, 6, 9- tπoxadecanoic acid (CH 3 -0-CH 2 -CH ? -0-CH 2 -CH 2 -0-CH (Cι 0 H 2 ι) - COOH) ; 3, 6, 9, 12-tetraoxatrιdecanoιc acid (CH 3 -0-CH 2 -CH 2 - 0-CH 2 -CH 2 -0-CH 2 -CH 2 -0-CH 2 -COOH) ; 3, 6, 9, 12, 15- pentaoxahexadecanoic acid (CH3-O-CH2-CH2-O-CH 2 -CH 2 -O-CH 2 - CH ? -0-CH 2 -CH2-0-CH ? -COOH) ; 2-methyl-3, 6, 9-trιoxadecanoιc acid (CH 3 -0-CH2-CH2-0-CH2-CH2-0-CH(CH 3 )-COOH) ; 10,10- dιmethyl-3, 6, 9-trιoxadecanoιc acid ( (CH 3 ) 2 CH-0-CH 2 -CH 2 - 0-CH 2 -CH 2 -0-CH 2 -COOH) ; 2-ethyl-3, 6, 9, 12-tetraoxatπ- decanoic acid (CH 3 -0-CH2-CH2-0-CH 2 -CH ? -0-CH2-CH2-0- CH (C 2 H 5 ) -COOH) ; 10-phenyl-3, 6, 9-trιoxadecanoιc acid (Phe-CH 2 -0-CH 2 -CH 2 -0-CH 2 -CH2-0-CH 2 -COOH) ; 3,6, 9-trιoxa- decanoic acid ethyl ester (CH3-O-CH2-CH2-O-CH2-CH2-O-CH2- COOC 2 H 5 ) ; 3, 6, 9-trιamιnodecanoιc acid (CH 3 -NH-CH 2 -CH 2 - NH-CH 2 -CH 2 -NH-CH 2 -COOH) ; 3, 6, 9, 12-tetraammotrιdecanoιc acid (CH 3 -NH-CH 2 -CH 2 -NH-CH 2 -CH 2 -NH-CH 2 -CH 2 -NH-CH 2 -COOH) ; 9-ammo-3, 6-dιoxadecanoιc acid (CH 3 -NH-CH 2 -CH 2 -0-CH 2 - CH 2 -0-CH 2 -COOH) ; 6, 9-dιamιno-3-oxadecanoιc acid (CH 3 -NH- CH 2 -CH 2 -NH-CH 2 -CH 2 -O-CH-2-COOH) ; 3, 6, 9-trιthιodecanoιc acid (CH 3 -S-CH 2 -CH 2 -S-CH 2 -CH 2 -S-CH 2 -COOH) ; 9,12-dιthιo- 3, 6-dιoxatrιdecanoιc acid (CH 3 -S-CH 2 -CH 2 -S-CH 2 -CH 2 -0-CH 2 - CH 2 -O-CH 2 -COOH) ; 9-amιno-3, 6-dιoxadecanoιc acid monoamide (CH3-NH-CH2-CH2-O-CH2-CH2-O-CH2-CONH2) ; 3,6,9- trioxadecanoic acid monoamide (CH3-O-CH 2 -CH2-O-CH2-CH2- O-CH2-CONH2) ; 10, 10-dimethyl-3, 6, 9-trioxadecanoic acid amide ( (CH 3 ) -2CH-O-CH2-CH2-O-CH2-CH2-O-CH2-CONH2) ; 10,10- dimethyl-3, 6, 9-trioxadecanoic acid ethyl ester ( (CH 3 ) 2 CH-0-CH2-CH2-0-CH2-CH 2 -0-CH 2 -COOC 2 H s ) ; 10,10- dimethyl-3, 6, 9-trioxadecanoic acid heptadecanyl ester ( (CH 3 )2CH-0-CH2-CH2-0-CH2-CH 2 -0-CH 2 -COOC 17 H3e,) ; and 10,10- dimethyl-3, 6, 9-trioxadecanoic acid ( (CH 3 ) 2 CH-0-CH 2 -CH 2 - 0-CH 2 -CH 2 -0-CH(CH 3 ) -COOH) . Compounds of Formula (I) are described as intermediates useful in the making of curing agents and hardeners for epoxy resins in U.S. Patent Nos. 5,017,675 and 5,319,004, both assigned to Hoechst AG. German Published Application No. DE-A-2936123 describes the preparation of such epoxy resin intermediate compounds. Such compounds are also commercially available from Hoechst AG. Compounds of Formula I can also be prepared from commercially available polamines, polyols and polythiols by routine chemical reactions well known to those skilled in the art such as amidation, catalytic oxidation, esterification and other well known organic chemistry synthetic protocols, as described in organic chemistry textbooks including March, Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 3rd ed., John Wiley Interscience (1985) and Carey et al. Advanced Organic Chemistry, 3rd ed. , Parts A and B, Plenum Press, New York (1990) . The oxa acid compounds useful in the topical compositions of this invention can also be in the form of derivatives that are converted back to an acidic form by action of hydrolytic enzymes in the skin such as glycosidases, phosphatases, esterases and amidases. Examples of suitable derivatives include esters of tormula I compounds with aliphatic alcohols, carbohydrates, amides, lactones and anhydrides As defined herein, all compounds of Formula (I) , and derivatives thereof, will be referred to collectively as "oxa acids" and/or "oxa compounds" and/or "oxa acid compounds". A "topical application" refers to spreading or laying directly onto the surface of skin. A "topical composition" refers to a composition intended to be directly layed onto or spread on the surface of skin. An "effective amount" means an amount of a compound or a composition sufficient to induce a positive change (e.g. normalization of desquamation) in the skin condition to be treated such as those attributed to, accompanied or exacerbated by abnormal desquamation. A "physiologically acceptable vehicle" or a "suitable topical vehicle" refers to drugs, cosmetics, medicaments or inert ingredients that are suitable for use in direct contact with human tissues without undue toxicity. All percentages refer to weight percent based on the total weight of the topical composition. In accordance with the invention, oxa compounds are used as active principals in topical applications to treat various skin conditions attributed to, accompanied by or exacerbated by abnormal desquamation. Such conditions include, but are not limited to, dry skin, ichthyosis, palmar and plantar hyperkeratoses, dandruff, lichen simplex chronicus, Dariers disease, keratoses, lentigmes, age spots, melasmas, blemished skin, acne, psoriasis, eczema, pruπtis, inflammatory dermatoses, striae distensae (i.e. stretch marks) , warts and calluses. The compounds are unexpectedly and surprisingly found to be useful as active agents in topical preparations for treating signs of dermatological aging, both photoaging and intrinsic aging, including skin wrinkles such as fine wrinkling in the eye area or "crows feet" or fine wrinkles around the mouth area, irregular pigmentation, sallowness, loss of skin resilience and elasticity. Oxa compounds and topical compositions containing them are also useful for treating disorders associated with the nails, cuticles and hair such as ingrown hair, folliculitis and Pseudofolliculitis barbae. The present compounds also soften hair and promote the elimination of hair ingrowths, making the compounds of Formula (I) useful in shaving compositions. The oxa compounds can be incorporated into the compositions as free acids or as corresponding salts derived by neutralization with organic or inorganic bases, such as tnethanolamine, argmine, lysme, potassium hydroxide, sodium hydroxide, lithium hydroxide and ammonium hydroxide. When used in combination with a physiologically acceptable vehicle to form a topical composition, the effective amount of the oxa acid compound can be within the range from about 0.1% to about 95%. Both the effective amount and the frequency of application will vary within this range based on the particular skin condition treated, the age and physical condition of the person under treatment, the severity of the condition, the duration of treatment, the nature of concurrent treatments, the specific compound or compositions employed, the pai .ιcular vehicle utilized to deliver the compound or compositions, and other like factors within the knowledge and expertise of those skilled in the art. Ihe efficacy of the oxa acid compounds in treating skin conditions has been found to be affected by the pH of the composition. Thus, it is believed desirable to maintain the pH of the composition in the acid range pH < 7.0, preferably pH < 5.0, most preferably in the pH range between 3.5 and 4.0. The pH of the composition can be adjusted by adding water soluble salts formed by strong bases (e.g. KOH, NaOH, NHOH) and weak acids (e.g. phosphoric acid, acetic acid, lactic acid, carbonic acid) . Examples of such salts include potassium biphosphate, sodium phosphate, sodium acetate, sodium lactate and the like. Other methods useful for adjusting the pH of topical compositions are known to those skilled in the art. Compositions of the present invention have clear advantages over alpha hydroxyacid formulations, including superior mildness. Formulations containing alpha hydroxyacids, such as glycolic and lactic acids, can cause substantial discomfort to some individuals and symptoms of severe skin irritation in others, upon facial application. While being significantly gentler to skin than glycolic acid formulations, the oxa acid compositions of the present invention are highly effective in normalizing the desquamation of the upper stratum corneum. Such normalization is required to alleviate the skin conditions listed above. The topical compositions of the present invention also have advantages over compositions containing dicarboxylic acids including better water solubility and superior stratum corneum desquamatory activity. Oxa acids easily dissolve m water to concentrations of at least 20 to 30% by weight. Therefore, oxa acids have now been found to allow a much wider range of composition flexibility. Dicarboxylic acids of moderate to long chain length, which have straight, all-carbon backbones, are virtually insoluble in water and other aesthetically acceptable vehicles. This severely limits the choice of delivery vehicles for the dicarboxylic acids. The desquamatory activity of such dicarboxylic acids is also questionable. For example, tests have demonstrated that formulations containing 5% and 10% dodecanedioic acid do not produce any normalizing effect on stratum corneum desquamation beyond that of its vehicle alone. Some specific examples of vehicles found to be suitable for use with the oxa acids include: (1) (a) about 2 wt. % to about 10 wt . % glycerin, (b) about 1 wt . % to about 10 wt. % propylene glycol, (c) about 0.1 wt . % to about 2 wt . % hydroxyethyl cellulose, (d) about 0.1 wt . % to about 1 wt. % imidazolidilyl urea, and (e) about 0.01 wt.% to about 2 wt . % disodium-EDTA; (2) (a) about 1 wt.% to about 10 wt.% glycerin, (b) about 1 wt.% to about 10 wt.% propylene glycol, (c) about 1 wt.% to about 10 wt.% octyl palmitate, (d) about 1 wt.% to about 10 wt.% myristyl myristate, (e) about 1 wt.% to about 6 wt . % cetearyl alcohol/ Ceteareth-20, (f) about 0.5 wt.% to about 6 wt.% glyceryl monostearate, (g) about 0.1 wt.% to about 2 wt.% hydroxyethyl cellulose, (h) about 0.1 wt.% to about 1 wt.% imidazolidilyl urea, (i) about 0.05 wt.% to about 0.5 wt.% methyl paraben, and (j) about 0.01 wt.% to about 2 wt . % disodium-EDTA; and (3) (a) about 2 wt.% to about 10 wt.% glycerin, (b) about 1 wt.% to about 10 wt.% octyl palmitate, (c) about 1 wt.% to about 10 wt.% myristyl myristate, (d) about 1 wt.% to about 7 wt. % cetearyl alcohol/ Ceteareth-20, (e) about 1 wt.% to about 10 wt.% propylene glycol, (f) about 1 wt.% to about 6 wt.% glyceryl monostearate, (g) about 0.1 wt.% to about 2 wt.% hydroxyethyl cellulose, (h) about 0.1 wt.% to about 1 wt.% imidazolidilyl urea, (i) about 0.05 wt.% to about 0.5 wt.% methyl paraben, and (j) about 0.01 wt.% to about 2 wt . % disodium-EDTA. The topical compositions of the present invention can be made as lotions. A first or more basic lotion comprises: about 0.1 wt.% to about 90 wt.%, preferably from about 1 wt.% to about 50 wt.%, and most preferably about 5 wt.% to about 20 wt.% of the oxa acid; and, the remainder water. A second lotion has about 0.1 wt.% to about 90 wt.%, preferably from about 1 wt.% to about 50 wt.%, and most preferably about 5 wt.% to about 20 wt.% of the oxa acid; about 0.5 wt.% to about 50 wt.% of an emollient; about 0.1 wt.% to about 30 wt.% of an emulsifier; and, the remainder water. The second lotion may also contain up to about 10 wt.% of a preservative; from about 0.1 wt.% to about 3 wt.% of a fragrance; and up to about 5 wt.% of a dye or a pigment . The topical composition of the invention can also be formulated as a cream. A first or more basic cream comprises about 0.1 wt.% to about 95 wt.%, preferably from about Iwt . % to about 50 wt.%, and most preferably about 5 wt.% to about 20 wt.% of the oxa acid; from about 0.5 wt.% to about 50 wt.% of an emollient; about 0.1 wt.% to about 6 wt.% of a thickener; and, the remainder water. A second, preferred cream comprises about 0.1 wt.% to about 90 wt.%, preferably from about 1 wt.% to about 50 wt.%, and most preferably about 5 wt.% to about 20 wt.% of the oxa acid; from about 0.5 wt.% to about 50 wt.% of an emollient; about 0.1 wt.% to about 30 wt.% of an emulsifier; about 0.1 wt.% to about 6 wt.% of a thickener; and, the remainder water. The oxa acid can be combined with most conventional emollients including mineral oil, petrolatum, paraffin, ceresin, ozokerite, microcrystralme wax, perhydrosqualene dimethyl polysiloxanes, ethylphenyl polysiloxanes, silicone- glycol copolymers, triglyceπde esters, acetylated monoglycerides, ethoxylated glycerides, alkyl esters of fatty acids, fatty acids and alcohols, lanolin and lanolin derivatives, polyhydric alcohol esters, sterols, beeswax derivatives, polyhydric alcohols and polyethers, and amides of fatty acids. Other suitable emollients can be found in Sagarin, Cosmetics, Science and Technology, 2nd Ed., vol. 1, pp. 32-43 (1972), the contents of which are incorporated herein by reference. The emulsifiers that can be cationic, anionic, nonionic, amphoteric, or a combination thereof. Nonionic emulsifiers are preferred. Exemplary nonionic emulsifiers are commercially available sorbitans, alkoxylated fatty alcohols and alkyl polyglycosides. Anionic emulsifiers may include soaps, alkyl sulfates, monoalkyl and dialkyl phosphates, alkyl sulphonates and acyl isothionates . Other suitable emulsifiers can be found in McCutcheon, Detergents and Emulsifiers, North American Edition, pp. 317-324 (1986), the contents of which are incorporated herein by reference. The preservatives suitable for use with the present compositions include alkanols, especially ethanol and benzyl alcohol, parabens, sorbates, urea derivatves, and isothiazolinones . While such lotions or creams can be made using conventional homogenization methods known to those skilled in the art, it is also possible to use a process of microfluidization that involves co-mixing the aqueous phase and the oil phase of such creams and lotions in a high-pressure homogenizer that reduces the emulsion particle size dramatically to about l/400th the size of those in creams and lotions prepared without applying high pressure. Microfluidization allows one to prepare elegant stable creams and lotions containing effective amounts of an oxa acid without the use of traditional emulsifiers and surfactants. The topical compositions of the invention can also be formulated as a micro-emulsion. A first, basic micro-emulsion system comprises about 0.1 wt.% to about 50 wt . , preferably from about 1 wt.% to about 30 wt.%, and most preferably about 5 wt.% to about 20 wt.% of the oxa acid; from about 0.5 wt.% to about 20 wt.% of a hydrocarbon; from about 0.5 wt.% to about 20 wt.% of an oil; and, the remainder water. A second, more preferred micro-emulsion system comprises about 1 wt.% to about 20 wt.% of the oxa acid; from about 0.5 wt.% to about 15 wt.% of a hydrocarbon; from about 1 wt.% to about 15 wt.% of an oil; from about 0.1 wt.% to about 10 wt.% of a fatty alcohol; up to 30 wt.% of a nonionic surfactant; and, the remainder water. The topical compositions of the present invention can be formulated as oil-in-water or water-in-oil emulsions, gels, lotions, ointments, sticks, sprays, tapes, patches. The inventive compositions can also be in the form of a multiphase emulsion, such as a water- in-oil-in-water type emulsion as disclosed in U.S. Patent No. 4,254,105, incorporated herein by reference. The compositions of the present invention can also be formulated as triple emulsions of the oil-in-water- silicone fluid type disclosed in U.S. Patent No. 4,960,764, incorporated herein by reference. The compositions of the invention can also be made as a liposomal formulation, for example, according to the methods described in Mezei, J. Pharmaceut. Pharmacol. , vol. 34, pp. 473-474 (1982), or modification thereof. In such compositions, droplets of the oxa acid solution can be entrapped inside the liposomal vesicles with the shell of the liposome being a phospholipid or other suitable lipids (e.g. skin lipids) . To form a topical composition, the liposomes can then be added to any carrier system described above according, for example, to the preparation modes, uses and compositions of topical liposomes described in Mezei, Topics n Pharmaceutical Sciences, Breimer et al. Eds., pp. 345-358, Elsevier Science Publishers BV, New York (1985), incorporated herein by reference, or according to the reverse-phase evaporation method described in Szoka et al., Proc. Nat. Acad. Sciences, vol. 75, pp. 4194-4198 (1978) , and Diploses et al., J_^ Soc. Cosmetic Chemists, vol. 43, pp93-100 (1992) , each of which is incorporated herein by reference. Solutions of oxa acids can also be entrapped in polymeric vesicles with a shell consisting of a suitable polymeric material, such as gelatin, cross- linked gelatin, polyamide, poylacrylates and the like, to form a vesicle that is then incorporated into the topical composition. The compositions of the present invention may include an oxa acid compound as the only active ingredient, or may use the oxa acid compound in combination with other cosmetic and pharmaceutical actives and excipients. Suitable other cosmetic and pharmaceutical agents include, but are not limited to, antifungals, vitamins, sunscreens, retinoids, antiallergenic agents, depigmenting agents, anti- inflammatory agents, anesthetics, surfactants, moisturizers, exfolients, stabilizers, preservatives, antiseptics, thickeners lubricants, humectants, chelating agents and skin penetration enhancers, as well as the emulsifiers, emollients, fragrances and colorants discussed above. Examples of suitable thickening agents include xanthan gum, xanthan gum brine tolerant, hydroxypropyl cellulose, hydroxyethyl cellulose, carbopol and gum acacia, Sepigel 305 (available from Seppic Co., France), vee-gum or magnesium aluminum silicate. In topical compositions, oxa acids are also compatible with, and their utility can be enhanced by, humectants, such as urea, PCA, amino acids, certain polyols and other compounds with hygroscopic properties . Topical compositions can also be formed to contain about 0.1 wt.% to about 90 wt.%, preferably from about 1 wt.% to about 50 wt.%, and most preferably about 5 wt.% to about 20 wt.% of the oxa acid, in combination with a keratolytic agent, such as salicylic acid and benzoyl peroxide, and skin lightening agents such as kojic acid benzoquinone, licorice derivatives, ascorbic acid and its derivatives (e.g. magnesium ascorbyl phosphate), and glycerhetmic acid and its derivatives. From about 0.1 wt.% to about 90 wt.%, preferably from about 1 wt.% to about 50 wt.%, and most preferably about 5 wt.% to about 20 wt.% of the oxa acid can be used to form a topical formulation in combination with organic and inorganic sunscreens, such as titanium dioxide, zinc oxide, benzylidene camphor, anthranilates, butylmethoxydibenzoylmethane, naphtholsulphonates and cinnamic acid derivatives . Of these, butylmethoxydibenzoylmethane and cinnamic acid derivatives are preferred. Topical compositions of the invention can also contain about 0.1 wt.% to about 90 wt.%, preferably from about 1 wt.% to about 50 wt.%, and most preferably about 5 wt.% to about 20 wt.% of the oxa acids co- formulated with (l) retinoids such as retmol, retmoic acid, retinyl palmitate, retinyl propionate, retinyl acetate, isotretinoin as well as synthetic retinoid mimics; (n) hormonal compounds such as estriol, estradiol, estrone or conjugated estrogens; (in) alpha-hydroxyacids or polyhydroxy alpha-hydroxy acid such as glycolic acid, lactic acid, tartaric acid, gulonic acid and other carboxylic acids and their monomeric, polymeric, cyclic or acyclic derivatives; (iv) alpha-keto acids such as pyruvic acid, 2- oxopropanoic acid, 2-oxobutanoιc acid, 2-oxopentanoιc acid, and the like. From about 0.1 wt.% to about 90 wt.%, preferably from about 1 wt.% to about 50 wt.%, and most preferably about 5 wt.% to about 20 wt.% of the oxa acids can also be utilized for additional benefits topical formulations containing one or more of the following: (l) vitamins including, for example, enzyme co- factors such as vitamin B6, vitamin B12, vitamin D3, 1, 25-dιhydroxy vitamin D3, vitamin Bl, vitamin B2, vitamin K, vitamin E, tocotrienols and their derivatives, nicotinic acid and its esters, pantothenic acid and it esters, panthenol, folic acid and its derivatives, chol e, carnitine and substances without formal vitamin status or "pseudo vitamins" such as vitamin F or cis, cis-lmoleic acid, vitamin M or pteroylglutamic acid, vitamins B10 and Bll, sesame seed factor, termitm, penicin, msectine, hypomyc and mycoine, vitamin L or anthranilic acid, vitamin L2 or adenylthiomethyl-pentose, myoinositol or cιs-1, 2,3,5- 7/46231 trans-4-6-cyclohexanehexol and its esters, especially phytic acid, laetrile or 1-mandelo-nιtrιle-beta- glucuronic acid, amygdalin, vitamin B15 or pangamic acid, vitamin B13 or orotic acid, vita ine H3 or procame hydrochloride, vitamin U or methyl-sulfonium salts of methionine, and pyrroloquinol e qumone; (n) antifungal agents including, for example, clotri azole, ketoconazole, iconazole, naftif e, tolnaftate, amphotericm B, nystatm, 5-fluorocytosme, griseofulvin, haloprogm, of which tolnaftate, haloprogm and miconazole are most preferred; (in) self-tanning agents including, for example, as dihydroxyacetone and lawsone, of which dihydroxy- acetone is most preferred; (iv) anti-mycobacteπal agents such as erythromycm, tetracyclm and related compounds, especially doxycyclin and methacyclm, cephalospoπns, penicillins, macrolides, peptide compounds such as novobiocm, vancomycin, oleandomyc paromomycin, leucomycme, amphomycin with macrolide molecules, qumolone derivatives and other compounds that interfere with bacterial cell wall synthesis, membrane function, RNA metabolism, purine, pyπmidine and protein synthesis, respiration or phosphorylation; (v) topical analgesics such as lidocaine, benzocame, butacaine, tetracaine, clove oil and eugenol, of which benzocame and lidocaine are most preferred; (vi) lipidic compounds essential for the skin's barrier function including, for example, ceramides, essential fatty acids and their esters, especially glycerides, ω-hydroxy fatty acids and their esters derived with alkanols through carboxylic hydroxyl or with, other fatty acids at the omega-hydroxyl, the latter type being most preferred, with phospholipids, cholesterol and its esters, such as cholesteryl hemisuccmate and cholesteryl phospate of which cholesterol phospate and essential fatty acids are most preferred, phytosterols, cholestanol and its derivatives. The lipidic compounds can be added to a topical composition either as singular molecular entities or as a complex mixture of lipids derived from either synthetic, animal or plant sources; (vn) antiallergenic agents and HI and/or H2 antihistammes, such as diphenylhydramme, clemizole, antazolme, thenaldine, phenyltoloxamme citrate, tπcyclic antiallerge ics such as ketotifene, dithiadene and 3-thιenylsulfide of thiadene, H2- receptor blockers, especially buπmamide, metiamide and cimetidien, cromolic acid and its salts; (vm) the oxa-acids can be used with topical anti-mflammatory agents that can reduce inflammation. These anti-mflammatory agents are used at concentrations from about 0.025 wt.% to 10 wt.%, preferably, 0.5 wt.% to 1 wt.%, with the concentration of the anti-mflammatory adjusted upward or downward depending upon the potency of the utilized agents. Examples of steroidal anti-mflammatories that can be used with oxa acids include hydrocortisone, hydroxytriamcilone, alpha-methyl dexamethasone, dexamethasone phosphate, beclamethasone dipropionate, hydrocortisone valerate, hydrocortisone cyclopentylpropionate, prednisolone, and mixtures thereof, with the most preferred being prednisolone and hydrocortisone; and (IX) non-steroidal anti-mflammatories can also be employed, such as described in Ramsford, Antimflammatory and Anti-Rheumatic Drugs, Vols. I-III, CRC Press, Boca Raton, Florida (1985), and specific examples of suitable NSAID's including, for example, oxicams (e.g. piroxicam, lsoxicam) , fenamic acid derivatives, meclofenamic acid derivatives (e.g. sodium meclofenamate) , flufenamic acid derivatives, mefenamic acid derivatives, propiomc acid esters, such as lbuprofen, naproxen, benoxaprofen, flubiprofen, ketoprofen, suprofen, of which lbuprofen is most preferred; pyrazolidmediones, of which phenylbutazone is most preferred; acetic acid derivatives, such as diclofenac, fenclofenac, mdomethacm, sulmdac, of which mdomethacm is most preferred; salicylic acid derivatives, such as, for example, aspnn, disalacid, and benorylate, of which aspirin and disalacid are most preferred. The compositions of the present invention may also include safe anti-mflammatory products of natural origin shown to possess anti-inflammatory activity, such as aloe vera extracts, extracts from genus Rubis (Rub a Cordifolia) , extracts from genus Commiphom (Co miphora Mukul), willow bark, matricarπa flowers, arnica flower, comfrey root, fenugreek seed and the like known to those skilled in the art. Topical compositions of the invention can contain from about 0.1 wt.% to about 90 wt.%, preferably from about 1 wt.% to about 50 wt.%, and most preferably about 5 wt.% to about 20 wt.% of the oxa acids in combination with antioxidants with phenolic hydroxy functions such as gallic acid derivataives (e.g. propyl gallate) , bio-flavonoids (e.g. quercetm, rutin, daidzein, genistem) , ferrulic acid derivatives (e.g. ethyl ferrulate, sodium ferrulate) , 6-hydroxy- 2, 5, 7, tetramethylchroman-2-carboxylιc acid. The compositions may also contain effective concentrations of water soluble antioxidants such as uric acid, reductic acid, tannic acid, rosmaπnic acid and catechms . Also of benefit is a coformulation from about 0.1 wt.% to about 90 wt.%, preferably from about 1 wt.% to about 50 wt.%, and most preferably about 5 wt.% to about 20 wt.% of the oxa acids with nitric oxide synthase inhibitors that reduce skin redness, vasodilation and inflammatory reactions, especially in response to electromagnetic and ionizing radiation or to the action of chemically or biochemically aggresive compounds. The nitric oxide synthase inhibitors can be added at concentrations from about 0.05 wt.% to 10 wt.%, most preferably from 1 wt.% to 3 wt.%, and selected from the group including guanidine derivatives, especially monoaminoguianid e and methylguanidine, L-argmme derivatives, especially N G - mtro-L-arginme and its esters, N G -monomethyl-L- argmine, 2-ιmmopιpperιdmes and other 2- lmmoazaheterocycles. Other possible anti-oxidants that the composition may contain are those that have one or more thiol functions (-SH) , in either reduced or non-reduced form, such as glutathione, lipoic acid, thioglycolic acid, and other sulfhydryl compounds. The levels of sulfhydryl anti-oxidants should not exceed 0.5 wt.% for cosmetic uses of the composition but may be higher for pharmaceutical uses as dictated by the considerations of efficacy. The composition may also include inorganic antioxidants, such as sulfites, bisulfites, metabi- sulfite, or other inorganic salts and acids containing sulfur oxidation state +4. The preferred level of inorganic sulfur-contammg antioxidants is from about 0.01 wt.% to about 0.5 wt.% with the most preferred level between about 0.1 wt.% and about 0.4 wt.%. Compositions of the invention can also include from about 0.1 wt.% to about 90 wt.%, preferably from about 1 wt.% to about 50 wt.%, and most preferably about 5 wt.% to about 20 wt.% of the oxa acids coformulated with about 0.025 wt.% to about 5 wt.%, with 0.5 wt.% to 2 wt.% preferred and with 0.5wt. % to 1 wt.% most preferred, of compounds known to be electron spin-traps such as nitrones, N-tertbutyl-nitrone and α- (4-pyrιdyl-l-oxιde) -N-tertbutyl-nitrone or other compounds known to form free radicals with half-life times of more than one minute. From about 0.1 wt.% to about 90 wt.%, preferably from about 1 wt.% to about 50 wt.%, and most preferably about 5 wt.% to about 20 wt.% of the oxa acids can also be used in compositions that contain insect repellents such as, aliphatic, cyclic or aromatic amides, citronella oil, terpineol, cineole, neem oil and terephthalic acid and its esters. Other suitable insect repellents can be found in Technical Bulletin No. 1549 from the U.S. Department of Agriculture or in their Agricultural Handbook Nos. 69, 340 and 461. The oxa acid-containing topical compositions of the present invention can also contain skin cooling compounds such as, by way of example, menthol, menthyl glycerol, asymmetrical carbonates, thiocarbonates and urethanes, N-substituted carboxamides, ureas or phosphine oxides such as described in J. Cosmet. Chem. , vol. 29, p. 185 (1978), menthyl lactate, and menthone glycerine acetal. The general activity and mildness to skin of the present topical compositions can also be enhanced by neutralization to pH 3.5 to 7.0, most preferably from pH 3.7 to 5.6, with one or more amphoteric and pseudoamphoteric compounds such as glycine, alanine, valine, serine, thionine, methionine, leucine, asparagine, histidine, glutamic acid, glutamine, lysine, cystine, cystein, tryptophan, serine, phenylalanine, citrulline, creatine, proline, 3- or 4- hydroxyproline, 5-hydroxylysine, ornithine and its derivatives, 3-aminopropanoic acid and other aminocarboxylic acids, canavanine, canaline, homoarginine, taurine, aminoaldonic acids and aminosugars, aminouronic acid, aminoaldaric acid, deacetylated hyaluronic acid, hyalobiuronic acid, chondrosine, desulfated heparin, neuraminic or sialic acid, methionine sulfone, glycylglycine, chondroitin, D, L-sphingosine, sphingomyelin, ophidine, glucagon, homocarnosine, phosphatidyl serine, cocoamphoglycine, phosphatidyl ethanolamine, cysteinesulfinic acid, glutathione, amphoteric inorganic oxides, polyamidoamines, polyamidoamine-based dendrimers, sodium hydroxymethylglycinate and polyethylene amine. The utility and mildness of the present topical compositions can also be enhanced by certain chelating agents incorporated into the composition at levels from about 0.01 wt.% to about 25 wt.%, more preferably from about 0.5 wt.% to about 10 wt.%, and most preferably from about 1 wt.% to about 5 wt.%. Suitable examples of chelating ager.„s include those that have a high affinity for zinc, calcium, magnesium, iron and/or copper ions, such as ethylene-diamme-tetra-acetic acid, (ethylenedioxy) -diethylene-dimtrilo-tetra-acetic acid, salicylaldoxime, quinolmol, diaminocyclohexane- tetra-acetic acid, diethylene-triammo-penta-acetic acid, dimethylglyoxime, benzoin oxime, tnethylenetetramine, desfemoxamine or mixtures thereof. The present invention also includes methods by which these compounds can be used to address the aforementioned skin conditions. Such methods include topically applying an effective amount of one or more compound of Formula (I) to the affected skin areas, normally once or twice daily. Such methods also include topically applying a composition containing an effective amount of one or more compounds of Formula (I) m a physiologically acceptable vehicle to the affected skin areas, normally once or twice daily. The methods of the present invention include the topical application of the compounds of Formula (I) in concentrations of up to 100%, when such compounds are a liquid at ambient temperature (e.g. 3, 6, 9-trιoxaun- decanedioic acid), and when using the oxa compounds, for example, for skin peels or for softening hair. The following examples are illustrative of the present invention and are not intended to limit the invention. EXAMPLES The compositions of the present invention are generally made into lotions, creams or gels for topical application. EXAMPLE 1 Preparation of Oxa Acid Topical Compositions In a suitable vessel, water, glycerin, propylene glycol Na 2 EDTA and 3, 6, 9-trioxadecanoic acid are added and mixed together. Ammonium hydroxide is added to the vessel in increme to adjust pH to the desired range. This pH-adjusted phase is then heated to 170-175°F. Hydroxyethyl cellulose is next adde with agitation until uniform to complete phase A. For the lotion and cream, phase B is added to a suitable, second vessel, combined and heated to 170- 175°F. Phase B is then added to phase A with sufficient mixing, again at 170-175°F. The batch is then cooled to 120°F. Phase C is added to the batch and mixed until uniform. 3,6, 9-trioxa- decanoic acid 10.00 10.00 10.00 hydroxyethyl cellulose 0.50 0.30 0.500 ammonium to pH to pH to pH hydroxide (30ι 3.7-3.9 3.7-3.9 3.7-3.9 Phase GEL (B) octyl palmitate myristyl myristate glyceryl monostearate 1.50 3.00 cetearyl alcohol & Ceteareth-20 methyl paraben (C) imidazolidilyl urea 0.30 All numbers are expressed as percentages of total weight of composition except for pH ranges and Q.S. for balance with water. Those skilled in the art will readily perceive possible vehicles other than lotions, creams or gels, after having the benefit of this disclosure. Microscopic normalization of desquamation of the stratum corneum or macroscopic exfoliation of the epidermis are prerequisite activities for alleviating the skin conditions for which the present oxa acid compounds and compositions are intended. The following example demonstrates, inter alia, the superior stratum corneum desquamatory activity provided by the present oxa acid compositions. EXAMPLE 2 Cream for Hyperpigmented Spots This example illustrates a cream that can be prepared and used to reduce appearance of hyper- pigmentation spots on the skin of hands. wt.% isopropyl myristate 3.0 polyethylene glycol (1000) monostearate 5.0 palmitic acid 10.0 3, 6, 9-trιoxadecanoιc acid 10.0 glycerine. 3.0 polyethylene glycol (300) monostearate 5.0 methyl paraben 0.2 magnesium ascorbyl phosphate 2.0 water 60.0 perfume & color to 100.0 triethanolamine to pH 4.0 All numbers are expressed as percentages of total weight of compositions except for reference to pH. EXAMPLE 3 Cream for Dry Skm, Ichthvosis and Hyperkeratoses This example illustrates a silicone cream that can be prepared and used to treat dry skm, ichthyosis and hyper-keratoses according to the present invention. wt. % Phase A laurylmethicone copolyol 2.0 mineral oil 1.0 lanolin 1.5 sunflower or soybean oil 10.0 cyclomethicone 6.0 oil soluble rosmary extract 2.0 Phase B sodium iodide 2.0 3, 6, 9-trιoxadecanoιc acid 9.0 3-aιmιno-6-oxaheptanoιc acid 1.0 sodium hydroxymethyl glycmate 0.5 demmeralized water to 100.0 sodium biphosphate to pH 3.8 All numbers are expressed as percentages of total weight of composition except for the reference to pH. EXAMPLE 4 Silicone Gel This example illustrates a water-m-silicone gel composition. wt . % Phase A dimethiconol 10.0 dimethicone copolyol 10.0 cyclomethicone 5.0 Phase B 3, 6-dioxaheptanoic acid 8.0 glycerine 20.0 demineralized water to 100.0 triethanoiamine to pH 4.0 All numbers are expressed as percentages of total weight of composition except for the reference to pH. EXAMPLE 5 Cream for Acne, Skin Blemishes and Age Spots This example illustrates a face cream than can be used to treat acne, skin blemishes and age spots. wt.% Phase A oleic acid 1.0 stearic acid 17.0 polyoxyethylene (20 propylene glycol monostrearate) 10.0 retinol 0.1 Phase B glycerine 5.0 2-pyrollidone-5-carboxylic acid 5.0 3, 6, 9-trioxadecanoic acid 7.5 3, 6-dioxaheptanoic acid amide 2.5 lactic acid 3.0 demineralized water to 100.0 ammonium hydroxide to pH 4.2 All numbers are expressed as percentages of-total composition except for the reference to pH. Various modifications and alterations to the present invention may be appreciated based on a review of this disclosure. These changes and additions are intended to be within the scope and spirit of this invention as defined by the following claims.

Claims: WHAT IS CLAIMED IS: 1. A topical composition comprising a suitable topical vehicle and a compound of Formula (I) : wherein R 4 is (CR 5 R 6 -CR 7 R8-Xι) n- RgRioRn, π is an integer from 1 to 18; Ri, R 2 , R3, R5, Re, R7, Rβ, R9, Rio and R n , are independently, hydrogen or non-hydrogen substituents; and X, Xj . , Y and Z are independently, 0, NH, or S. 2. The composition of claim 1, wherein said compound of Formula (I) comprises about 0.1 wt.% to about 95 wt.% of said composition. 3. The composition of claim 2, wherein said compound of formula (I) comprises about 1 wt.% to about 50 wt.% of said composition. 4. The composition of claim 3, wherein said compound of formula (I) comprises about 5 wt.% to about 20 wt.% of said composition. 5. The composition of claim 1, wherein n is an integer from 2 to 12. 6. The composition of claim 1, further comprising a mixture of at least two different compounds of Formula (I) . 7. The composition of claim 1, wherein the non- hydrogen substituents of said compound are selected from the group consisting of alkyls, alkenyls, oxa- alkyls, aralkyls and aryls. 8. The composition of claim 7, wherein said non- hydrogen substituents are selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, hexyl, heptyl, octyl, nonyl, dodecanyl, methoxy, ethoxy, propoxy, butoxy, cyclohexenyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, cyclobutyl and cyclohexanyl . 9. The composition of claim 1, wherein Ri, R 2 , R , R 5 , R 6 , R 7 , Rβ, R9, Rio and R n , are each hydrogen. 10. The composition of claim 1, wherein X, X lr Y and Z are each oxygen. 11. The composition of claim 1, wherein X, X l r Y and Z are each amino groups. 12. The composition of claim 1, wherein X, X lf Y and Z are each sulfur. 13. The composition of claim 1, wherein said compound is selected from the group consisting of 3,6- dioxaheptanioic acid, 7, 7-dimethyl-3, 6-dioxaheptanoic acid, 3, 6-dioxaheptanoic acid ethyl ester, 3, 6- dioxaheptanoic acid amine, 3, 6-dioxaheptanoic acid dodecyl ester, 2-phenyl-3, 6-dioxaheptanoic acid, 2- benzyl-3, 6-dioxaheptanoic acid, 2-methyl-3, 6- dioxaheptanoic acid, 3-amino-6-oxaheptanoic acid, 3, 6, 9-trioxadecanoic acid, 2-phenyl-3, 6, 9- trioxadecanoic acid, 2-benzyl-3, 6, 9-trioxadecanoic acid, 2-decyl-3, 6, 9-trioxadecanoic acid, 3,6,9,12- tetraoxatridecanoic acid, 3,6,9,12,15- pentaoxahexadecanoic acid, 2-methy " -3, 6, 9- trioxadecanoic acid, 10, 10-dιmethyl-3, 6, 9- trioxadecanoic acid, 2-ethyl-3, 6, 9, 12-tetraoxatrι- decanoic acid, 10-phenyl-3, 6, 9-trιoxadecanoιc acid, 3, 6, 9-trιoxa-decanoιc acid ethyl ester, 3,6,9- triam odecanoic acid, 3, 6, 9, 12-tetraammotπdecanoιc acid, 9-ammo-3, 6-dιoxadecanoιc acid, 6, 9-dιamιno-3- oxadecanoic acid, 3, 6, 9-trιthιodecanoιc acid, 9,12- dιthιo-3, 6-dιoxatrιdecanoιc acid, 9-ammo-3,6- dioxadecanoic acid monoamide, 3, 6, 9-trιoxadecanoιc acid monoamide, 10, 10-dιmethyl-3, 6, 9-trιoxadecanoιc acid amide, 10, 10-dιmethyl-3, 6, 9-trιoxadecanoιc acid ethyl ester, 10, 10-dιmethyl-3, 6, 9-trιoxadecanoιc acid heptadecanyl ester, 10, 10-dιmethyl-3, 6, 9-trιoxadecanoιc acid and mixtures thereof. 14. The composition of claim 1, wherein said vehicle is selected from the group consisting of lotion, cream and gel. 15. The composition of claim 1, further comprising at least one active selected from the group consisting of antifungals, vitamins, sunscreens, retinoids, antiallergenic agents, depigment g agents, anti-inflammatory agents, anesthetics, surfactants, moisturizers, exfolients, emulsifiers, stabilizers, preservatives, antiseptics, emollients, thickeners, lubricants, humectants, chelating agents, fragrances, colorants and skin penetration enhancers. 16. The composition of claim 1, wherein said composition has a pH of less than 7.0. 17. The composition of claim 16, wherein said pH is about 3.5 to about 7.0 18. The composition of claim 17, wherein said pH is about 3.5 to about 4.0. 19. The composition of claim 2, wherein said composition comprises about 1 wt.% to about 50 wt.% of said compound of Formula (I) and has a pH of less than 7.0. 20. The composition of claim 16, wherein said topical vehicle comprises 0.1 wt.% to about 95 wt.% of said compound of formula (I) ; 0.5 wt.% to about 50 wt.% of an emollient; and about 0.1 wt.% to about 30 wt.% of an emulsifier. 21. The composition of claim 20, wherein said compound is selected from the group consisting of 3,6- dioxaheptanoic acid, 3, 6, 9-trioxadecanoic acid, 3, 6, 9, 12-tetraoxatridecanoic acid and 3,6,9,12,15- pentaoxahexadecanoic acid; and wherein said emollient is selected from the group consisting of mineral oil, petrolatum, paraffin, ceresin, ozokerite, microcrystalline wax, perhydrosqualene, dimethyl polysiloxanes, methylphenyl polysiloxanes, silicone-glycol copolymers, triglyceride esters, acetylated monoglycerides, ethoxylated glycerides, alkyl esters of fatty acids, fatty acids and alcohols, lanolin and lanolin derivatives, polyhdric alcohol esters, sterols, beeswax derivatives, polyhydric alcohols and polyethers, and amides of fatty acids; and wherein said emulsifier is selected from the group consisting of sorbitans, alkoxylated fatty alcohols, alkylpolyglycosides, soaps, alkyl sulfates, monoalkyl and dialkyl phosphates, alkyl sulphonates, and acyl isothionates. 22. The composition of claim 2, wherein said composition is in a form selected from the group consisting of an oil-in-water emulsion, a water-in-oil emulsion, a water-in-oil-in-water emulsion and an oil- in-water-in silicone fluid emulsion. 23. The composition of claim 14, wherein said topical vehicle comprises an ingredient selected from the group consisting of ammonium hydroxide, cetearyl alcohol/Ceteareth-20, EDTA, glycerin, glyceryl monostearate, hydroxyethyl cellulose, imidazolidilyl urea, methyl paraben, myristyl myristate, octyl palmitate and propylene glycol and mixtures thereof. 24. The composition of claim 14, comprising about 0.1 wt.% to about 20 wt.% 3, 6, 9-trioxadecanoic acid and a vehicle. 25. The composition of claim 22, wherein said vehicle comprises: (a) about 2 wt.% to about 10 wt.% glycerin; and (b) about 1 wt.% to about 10 wt.% propylene glycol; and said composition has a pH of about 7.0 or less. 26. The composition of claim 25, wherein said vehicle further comprises about 0.1 wt.% to about 2 wt.% hydroxyethyl cellulose. 27. The composition of claim 26, wherein said vehicle further comprises: about 0.1 wt.% to about 1 wt.% imidazolidilyl urea; and about 0.01 wt.% to about 2 wt.% disodium-EDTA. 28. The composition of claim 24, wherein said vehicle comprises: (a) about 1 wt.% to about 10 wt.% glycerin; (b) about 1 wt.% to about 10 wt.% propylene glycol; (c) about 1 wt.% to about 10 wt.% octyl palmitate; (d) about I wt.% to about 10 wt.% myristyl myristate; (e) about 1 wt.% to about 6 wt.% cetearyl alcohol/ Ceteareth-20; and (f) about 0.5 wt.% to about 6 wt . % glyceryl monostearate; and said composition has a pH of about 7.0 or less . 29. The composition of claim 28, wherein said vehicle further comprises about 0.1 wt.% to about 2 wt.% hydroxyethyl cellulose. 30. The composition of claim 29, wherein said vehicle further comprises: about 0.1 wt.% to about 1 wt.% imidazolidilyl urea; about 0.05 wt.% to about 0.5 wt.% methyl paraben;and about 0.01 wt.% to about 2 wt.% disodium-EDTA. 31. The composition of claim 24, wherein said vehicle comprises: (a) about 2 wt.% to about 10 wt.% glycerin; (b) about 1 wt.% to about 10 wt.% octyl palmitate; (c) about 1 wt.% to about 10 wt.% myristyl myristate; (d) about 1 wt.% to about 7 wt.% cetearyl alcohol/ Ceteareth-20; (e) about 1 wt.% to about 10 wt.% propylene glycol; (f) about 1 wt.% to about 6 wt . % glyceryl monostearate; and said composition has a pH of about 7.0 or less 32. The composition of claim 31, wherein said vehicle further comprises about 0.1 wt.% to about 2 wt.% hydroxyethyl cellulose. 33. The composition of claim 32, wherein said vehicle further comprises: about 0.1 wt.% to about 1 wt.% imidazolidilyl urea; about 0.05 wt.% to about 0.5 wt.% methyl paraben; and about 0.01 wt.% to about 2 wt.% disodium-EDTA. 34. A method for treating skin conditions caused by, accompanied with or exacerbated by abnormal desquamation, comprising, applying to said skin an effective amount of a compound of Formula (I) : wherein R 4 is (CR5R6~CR 7 R 8 -Xι) n-CRgRioRu, n is an integer from 1 to 18; Ri, R 2 , R 3 , R 5 , R 6 , R , R 8 , R 9 , R 10 and R u , are independently, hydrogen or non-hydrogen substituents; and X, Xi, Y and Z are independently, 0, NH, or S. 35. The method of claim 34, wherein said compound is combined with a suitable topical vehicle in a topical composition. 36. The method of claim 34, further comprising, applying to said skin an effective amount of a mixture of two or more different compounds of Formula (I) . 37. The method of claim 35, wherein said compound of Formula (1) comprises about 0.1 wt.% to about 95 wt.% of said composition. 38. The method of claim 37, wherein said compound of formula (I) comprises about 1 wt.% to about 50 wt.% of said composition. 39. The method of claim 37, wherein n is an integer from 2 to 12. 40. The method of claim 34, wherein the non- hydrogen substituents of said compound are selected from the group consisting of alkyl, alkenyl, oxa-alkyl, aralkyl and aryl. 41. The method of claim 40, wherein said non- hydrogen substituents of said compound are selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, r xyl, heptyl, octyl, nonyl, dodecanyl, methoxy, ethoxy, propoxyl, butoxy, cyclohexenyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, cyclobutyl and cyclohexanyl . 42. The method of claim 34, wherein R lf R 2 , R 3 , R 5 , R 6 , R 7 , R 8 , R9, Rio, and R u are each hydrogen. 43. The method of claim 34, wherein X, Xj, Y and Z are each oxygen. 44. The method of claim 34, wherein X, X l f Y and Z are each amino groups. 45. The method of claim 34, wherein X, Xi, Y and Z are each sulfur. 46. The method of claim 34, wherein said compound is selected from the group consisting of 3,6- dioxaheptanioic acid, 7, 7-dimethyl-3, 6-dioxaheptanoic acid, 3, 6-dioxaheptanoic acid ethyl ester, 3, 6- dioxaheptanoic acid amine, 3, 6-dioxaheptanoic acid dodecyl ester, 2-phenyl-3, 6-dioxaheptanoic acid, 2- benzyl-3, 6-dioxaheptanoic acid, 2-methyl-3, 6- dioxaheptanoic acid, 3-amino-6-oxaheptanoic acid, 3, 6, 9-trioxadecanoic acid, 2-phenyl-3, 6, 9- tπoxadecanoic acid, 2-benzyl-3, 6, 9-trιoxadecanoιc acid, 2-decyl-3, 6, 9-trιoxadecanoιc acid, 3,6,9,12- tetraoxatπdecanoic acid, 3,6,9,12,15- pentaoxahexadecanoic acid, 2-methyl-3, 6, 9- trioxadecanoic acid, 10, 10-dιmethyl-3, 6, 9- trioxadecanoic acid, 2-ethyl-3, 6, 9, 12-tetraoxatπ- decanoic acid, 10-phenyl-3, 6, 9-trιoxadecanoιc acid, 3, 6, 9-trιoxa-decanoιc acid ethyl ester, 3,6,9- tπammodecanoic acid, 3, 6, 9, 12-tetraammotrιdecanoιc acid, 9-ammo-3, 6-dιoxadecanoιc acid, 6, 9-dιammo-3- oxadecanoic acid, 3, 6, 9-trιthιodecanoιc acid, 9,12- dιthιo-3, 6-dιoxatrιdecanoιc acid, 9-ammo-3,6- dioxadecanoic acid monoamide, 3, 6, -trιoxadecanoιc acid monoamide, 10, 10-dιmethyl-3, 6, 9-trιoxadecanoιc acid amide, 10, 10-dιmethyl-3, 6, 9-trιoxadecanoιc acid ethyl ester, 10, 10-dιmethyl-3, 6, 9-trιoxadecanoιc acid heptadecanyl ester, 10, 10-dιmethyl-3, 6, 9-trιoxadecanoιc acid and mixtures thereof. 47. The method of claim 46, wherein said compound is 3, 6, 9-trιoxadecanoιc acid. 48. The method of claim 34, wherein said skm conditions are selected from the group consisting of dry skin, ichthyosis, palmar and plantar hyperkeratoses, dandruff, lichen simplex chromcus, Dariers disease, keratoses, lentigmes, age spots, melasmas, blemished skin, acne, psoriasis, eczema, pruritis, inflammatory dermatoses, striae distensae, warts, calluses, signs of dermatological aging, skm wrinkles, fine wrinkles around the mouth area, irregular pigmentation, sallowness, loss of skm resilience and elasticity, and disorders associated with nails, cuticles and hair. 49. The method of claim 35, wherein said composition further comprises at least one active selected from the group consisting of antifungals, vitamins, sunscreens, retinoids, antiallergenic agents, depigmentmg agents, anti-mflammatory agents, anesthetics, surfactants, moisturizers, exfolients, emulsifiers, stabilizers, preservatives, antiseptics, emollients, thickeners, lubricants, humectants, chelating agents, fragrances, colorants and skm penetration enhancers. 50. A method of peeling skin comprising, applying to said skin, a compound of formula I: wherein R 4 is (CRsRβ-CR-jRβ-Xi) n -CR 9 Rι 0 Rιι, n is an integer from 1 to 18; Ri, R 2 , R 3 , Rs, Re, Rv, B, 9 , Rio and Ru, are independently, hydrogen or non-hydrogen substituents; and X, X ϊ f Y and Z are independently, 0, NH, or S. 51. A method of softening hair comprising, applying to said hair, a compound of Formula I: wherein R 4 is (CR 5 R 6 -CR 7 R 8 -X 1 ) n -CR 9 Rι 0 Rn, n is an integer from 1 to 18; R lf R 2 , R 3 , R 5 , R 6 , , Rβ, R_, Rio and R u , are independently, hydrogen or non-hydrogen substituents; and X, X l f Y and Z are independently, 0, NH, or S.

Inventors: KALAFSKY ROBERT, PTCHELINTSEV DMITRI, SCANCARELLA NEIL, KALAFSKY, ROBERT, PTCHELINTSEV, DMITRI, SCANCARELLA, NEIL
Applicants: AVON PROD INC, AVON PRODUCTS, INC.
Application year: 1997
Main classification: A61K31
IPC codes: A61K8, A61K31, A61K45, A61P17, A61Q3, A61Q5, A61Q19