CNS-PENETRANT NK-1 RECEPTOR ANTAGONISTS AS ANTIDEPRESSANT AND/OR AN ANTI-ANXIETY AGENT

Abstract: The present invention relates to the treatment or prevention of depression and/or anxiety by the administration of a combination of a specific class of NK-1 receptor antagonists and an antidepressant or anti-anxiety agent. The present invention also provides preclinical screens for anxiolytic and antidepressant activity of NK-1 receptor antagonists.

Description: CNS-PENETRANT NK-1 RECEPTOR ANTAGONISTS AS ANTIDEPRESSANT AND/OR AN ANTI-ANXIETY AGENT This invention relates to the treatment or prevention of depression and/or anxiety by the administration of a combination of a specific class of NK-1 receptor antagonists and an antidepressant or anti- anxiety agent. The present invention also provides preclinical screens for anxiolytic and antidepressant activity of NK-1 receptor antagonists. Major depression is characterised by feelings of intense sadness and despair, mental slowing and loss of concentration, pessimistic worry, agitation, and self-deprecation. Physical changes also occur, especially in severe or "melancholic" depression. These include insomnia or hypersomnia, anorexia and weight loss (or sometimes overeating), decreased energy and libido, and disruption of normal circadian rhythms of activity, body temperature, and many endocrine functions. Treatment regimens commonly include the use of tricyclic antidepressants, monoamine oxidase inhibitors, some psychotropic drugs, lithium carbonate, and electroconvulsive therapy (ECT) (see R. J. Baldessarini in Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th Edition, Chapter 19, McGraw-Hill, 1996 for a review). More recently, new classes of antidepressant drugs are being developed including selective serotonin reuptake inhibitors (SSRIs), specific monoamine reuptake inhibitors and 5-HTiA receptor agonists, antagonists and partial agonists. Anxiety is an emotional condition characterised by feelings such as apprehension and fear accompanied by physical sympoms such as tachycardia, increased respiration, sweating and tremor. It is a normal emotion but when it is severe and disabling it becomes pathological. Anxiety disorders are generally treated using benzodiazepine sedative -antianxiety agents. Potent benzodiazepines are effective in panic disorder as well as in generalised anxiety disorder, however, the risks associated with drug dependency may limit their long-term use. 5-HT I A receptor partial agonists also have useful anxiolytic and other psychotropic activity, and less likelihood of sedation and dependance (see R. J. Baldessarini in Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th Edition, Chapter 18, McGraw-Hill, 1996 for a review). Neurokinin 1 (NK-1; substance P) receptor antagonists are being developed for the treatment of a number of physiological disorders associated with an excess or imbalance of tachykinins, and in particular substance P. Examples of such conditions include disorders of the central nervous system such as anxiety, depression and psychosis (see, for instance, International (PCT) patent specification Nos. WO 95/16679, WO 95/18124 and WO 95/23798). It might therefore be desirable to investigate the treatment of depression and/or anxiety using a combination of a tachykinin antagonist and an antidepressant and/or an anti-anxiety agent. Indeed, such a desideratum has already been considered in International (PCT) patent specification No. WO 96/24353 (published 15th August 1996) which claims methods for the treatment of psychiatric disorders using a combination of a tachykinin antagonist and a serotonin agonist or selective serotonin reuptake inhibitor. However, the disclosure of WO 96/24353 does not provide any teaching as to whether the claimed combination has any efficacy and in particular there is no direction towards specific combinations which might potentiate the antidepressant or anxiolytic effects of the individual therapeutic agents. There is no clear direction from WO 96/24353 to which class of tachykinin antagonist (e.g. NK-1, NK-2 or NK-3 receptor antagonists) would be of use in the claimed combinations, nor how a person of ordinary skill in the art might identify suitable compounds for use in combination with a serotonin agonist or a selective serotonin reuptake inhibitor. Furthermore, there is no teaching which would enable a person of ordinary skill in the art to identify those compounds with sustained activity following oral administration for use in the claimed combinations. At best, WO 96/24353 merely recites in one document that which was already recognised in the art, namely that tachykinin antagonists might be of use in the treatment of psychiatric disorders and that serotonin agonists and selective serotonin reuptake inhibitors are effective in the treatment of psychiatric disorders. There therefore remains a need for an effective combination of an antidepressant and or an anti-anxiety agent with a NK-1 receptor antagonist, which combination provides an unexpected and advantageous antidepressant or anxiolytic effect. Such combinations may for example provide an enhanced antidepressant or anxiolytic effect. They may also provide for a rapid onset of action to combat depression and/or anxiety thereby enabling prescription on an "as-needed" basis. CNS-penetrant NK-1 receptor antagonists have been found to provide an unexpected effect relevant to the treatment and prevention of depression and/or anxiety when used in combination with an antidepressant or anti-anxiety agent. While not being bound to any particular theory of operation, an enhanced effect at treating or preventing a psychological stress response in an animal assay is observed with the combination of drugs than would be expected from either drug alone. In particular, combination therapy of a CNS-penetrant NK- 1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V), and a selective serotonin reuptake inhibitor or a 5-HTIA receptor agonist or antagonist effectively inhibits separation -induced vocalisations in guinea-pig pups. This is indicative of efficacy in the treatment of depression and/or anxiety. Such unexpected results would not have been predicted based on the disclosures in the art. The present invention accordingly provides the use of a CNS- penetrant NK-1 receptor antagonist and an antidepressant or anti-anxiety agent for the manufacture of a medicament for the treatment or prevention of depression and/or anxiety. The present invention also provides a method for the treatment or prevention of depression and/or anxiety, which method comprises administration to a patient in need of such treatment an amount of a CNS-penetrant NK-1 receptor antagonist and an amount of an antidepressant or anti-anxiety agent, such that together they give effective relief. In a further aspect of the present invention, there is provided a pharmaceutical composition comprising a CNS-penetrant NK-1 receptor antagonist and an antidepressant or anti-anxiety agent, together with at least one pharmaceutically acceptable carrier or excipient. It will be appreciated that the CNS-penetrant NK-1 receptor antagonist and antidepressant or anti-anxiety agent may be present as a combined preparation for simultaneous, separate or sequential use for the treatment or prevention of depression and/or anxiety. Such combined preparations may be, for example, in the form of a twin pack. In a further or alternative aspect of the present invention, there is therefore provided a product comprising a CNS-penetrant NK-1 receptor antagonist and an antidepressant or anti-anxiety agent as a combined preparation for simultaneous, separate or sequential use in the treatment or prevention of depression and/or anxiety. It will be appreciated that when using a combination of the present invention, both the CNS-penetrant NK-1 receptor antagonist and the antidepressant or anti-anxiety agent will be administered to a patient, within a reasonable period of time. The compounds may be in the same pharmaceutically acceptable carrier and therefore administered simultaneously. They may be in separate pharmaceutical carriers such as conventional oral dosage forms which are taken simultaneously. The term "combination" also refers to the case where the compounds are provided in separate dosage forms and are administered sequentially. Therefore, by way of example, the antidepressant or anti-anxiety agent may be administered as a tablet and then, within a reasonable period of time, the CNS-penetrant NK-1 receptor antagonist may be administered either as an oral dosage form such as a tablet or a fast-dissolving oral dosage form. By a "fast dissolving oral formulation" is meant, an oral delivery form which when placed on the tongue of a patient, dissolves within about 10 seconds. By "reasonable period of time" is meant a time period that is not in excess of about 1 hour. That is, for example, if the antidepressant or antianxiety agent is provided as a tablet, then within one hour, the CNS- penetrant NK-1 receptor antagonist should be administered, either in the same type of dosage form, or another dosage form which provides effective delivery of the medicament. The compositions of the present invention are useful for the treatment of depression. As used herein, the term "depression" includes depressive disorders, for example, single episodic or recurrent major depressive disorders, and dysthymic disorders, depressive neurosis, and neurotic depression; melancholic depression including anorexia, weight loss, insomnia and early morning waking, and psychomotor retardation; atypical depression (or reactive depression) including increased appetite, hypersomnia, psychomotor agitation or irritability, anxiety and phobias; seasonal affective disorder; or bipolar disorders or manic depression, for example, bipolar I disorder, bipolar II disorder and cyclothymic disorder. Other mood disorders encompassed within the term "depression" include dysthymic disorder with early or late onset and with or without atypical features; dementia of the Alzheimer's type, with early or late onset, with depressed mood; vascular dementia with depressed mood; mood disorders induced by alcohol, amphetamines, cocaine, hallucinogens, inhalants, opioids, phencyclidine, sedatives, hypnotics, anxiolytics and other substances; schizoaffective disorder of the depressed type; and adjustment disorder with depressed mood. The compositions of the present invention are useful for the treatment of anxiety. As used herein, the term "anxiety" includes anxiety disorders, such as panic disorder with or without agoraphobia, agoraphobia without history of panic disorder, specific phobias, for example, specific animal phobias, social phobias, obsessive-compulsive disorder, stress disorders including post-traumatic stress disorder and acute stress disorder, and generalised anxiety disorders. "Generalised anxiety" is typically defined as an extended period (e.g. at least six months) of excessive anxiety or worry with symptoms on most days of that period. The anxiety and worry is difficult to control and may be accompanied by restlessness, being easily fatigued, difficulty concentrating, irritability, muscle tension, and disturbed sleep. "Panic disorder" is defined as the presence of recurrent panic attacks followed by at least one month of persistent concern about having another panic attack. A "panic attack" is a discrete period in which there is a sudden onset of intense apprehension, fearfulness or terror. During a panic attack, the individual may experience a variety of symptoms including palpitations, sweating, trembling, shortness of breath, chest pain, nausea and dizziness. Panic disorder may occur with or without agoraphobia. "Phobias" includes agoraphobia, specific phobias and social phobias. "Agoraphobia" is characterised by an anxiety about being in places or situations from which escape might be difficult or embarrassing or in which help may not be available in the event of a panic attack. Agoraphobia may occur without history of a panic attack. A "specific phobia" is characterised by clinically significant anxiety provoked by exposure to a specific feared object or situation. Specific phobias include the following subtypes: animal type, cued by animals or insects; natural environment type, cued by objects in the natural environment, for example storms, heights or water; blood-injection-injury type, cued by the sight of blood or an injury or by seeing or receiving an injection or other invasive medical procedure; situational type, cued by a specific situation such as public transportation, tunnels, bridges, elevators, flying, driving or enclosed spaces; and other type where fear is cued by other stimuli. Specific phobias may also be referred to as simple phobias. A "social phobia" is characterised by clinically significant anxiety provoked by exposure to certain types of social or performance circumstances. Social phobia may also be referred to as social anxiety disorder. Other anxiety disorders encompassed within the term "anxiety" include anxiety disorders induced by alcohol, amphetamines, caffeine, cannabis, cocaine, hallucinogens, inhalants, phencyclidine, sedatives, hypnotics, anxiolytics and other substances, and adjustment disorders with anxiety or with mixed anxiety and depression. Anxiety may be present with or without other disorders such as depression in mixed anxiety and depressive disorders. The compositions of the present invention are therefore useful in the treatment of anxiety with or without accompanying depression. The compositions of the present invention are especially useful for the treatment of or prevention of depression and/or anxiety where the use of an antidepressant or anti-anxiety agent is generally prescribed. By the use of a combination of a CNS-penetrant NK-1 receptor antagonist and an antidepressant or anti-anxiety agent in accordance with the present invention, it is now also possible to treat or prevent depression and/or anxiety in patients for whom conventional antidepressant or anti-anxiety therapy might not be wholly successful or where dependance upon the antidepressant or anti-anxiety therapy is prevalent. Suitable classes of antidepressant agent of use in the present invention include norepinephrine reuptake inhibitors, selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), reversible inhibitors of monoamine oxidase (RIMAs), serotonin and noradrenaline reuptake inhibitors (SNRIs), corticotropin releasing factor (CRF) antagonists, α-adrenoreceptor antagonists and atypical antidepressants. Another class of antidepressant agent of use in the present invention are noradrenergic and specific serotonergic antidepressants (NaSSAs). A suitable example of a NaSSA is mirtazapine. Suitable norepinephrine reuptake inhibitors of use in the present invention include tertiary amine tricyclics and secondary amine tricyclics. Suitable examples of tertiary amine tricyclics include: amitriptyline, clomipramine, doxepin, imipramine and trimipramine, and pharmaceutically acceptable salts thereof. Suitable examples of secondary amine tricyclics include: amoxapine, desipramine, maprotiline, nortriptyline and protriptyline, and pharmaceutically acceptable salts thereof. Another norepinephrine reuptake inhibitor of use in the present invention is reboxetine. Suitable selective serotonin reuptake inhibitors of use in the present invention include: fluoxetine, fluvoxamine, paroxetine and sertraline, and pharmaceutically acceptable salts thereof. Suitable monoamine oxidase inhibitors of use in the present invention include: isocarboxazid, phenelzine, tranylcypromine and selegiline, and pharmaceutically acceptable salts thereof. Suitable reversible inhibitors of monoamine oxidase of use in the present invention include: moclobemide, and pharmaceutically acceptable salts thereof. Suitable serotonin and noradrenaline reuptake inhibitors of use in the present invention include: venlafaxine, and pharmaceutically acceptable salts thereof. Suitable CRF antagonists of use in the present invention include those compounds described in International Patent Specification Nos. WO 94/13643, WO 94/13644, WO 94/13661, WO 94/13676 and WO 94/13677. Suitable atypical antidepressants of use in the present invention include: bupropion, lithium, nefazodone, trazodone and viloxazine, and pharmaceutically acceptable salts thereof. Another suitable atypical antidepressant is sibutramine. Other antidepressants of use in the present invention include adinazolam, alaproclate, amineptine, amitriptyline/chlordiazep oxide combination, atipamezole, azamianserin, bazinaprine, befuraline, bifemelane, binodaline, bipenamol, brofaromine bupropion, caroxazone, cericlamine, cianopramine, cimoxatone, citalopram, clemeprol, clovoxamine, dazepinil, deanol, demexiptiline, dibenzepin, dothiepin, droxidopa, enefexine, estazolam, etoperidone, femoxetine, fengabine, fezolamine, fluotracen, idazoxan, indalpine, indeloxazine, iprindole, levoprotiline, litoxetine, lofepramine, medifoxamine, metapramine, metralindole, mianserin, milnacipran, minaprine, mirtazapine, montireHn, nebracetam, nefopam, nialamide, nomifensine, norfluoxetine, orotirelin, oxaflozane, pinazepam, pirHndone, pizotyhne, ritanserin, roHpram, sercloremine, setiptiline, sibutramine, sulbutiamine, sulpiride, teniloxazine, thozalinone, thymohberin, tianeptine, tiflucarbine, tofenacin, tofisopam, toloxatone, tomoxetine, veralipride, viqualine, zimelidine and zometapine, and pharmaceutically acceptable salts thereof, and St. John's wort herb, or Hypericum perforatum, or extracts thereof. Suitable classes of anti-anxiety agent of use in the present invention include benzodiazepines and 5-HTIA agonists or antagonists, especially 5-HTIA partial agonists, and corticotropin releasing factor (CRF) antagonists. In addition to benzodiazepines, other suitable classes of antianxiety agent are nonbenzodiazepine sedative-hypnotic drugs such as zolpidem; mood-stabilizing drugs such as clobazam, gabapentin, lamotrigine, loreclezole, oxcarbamazepine, stiripentol and vigabatrin; and barbiturates. Suitable benzodiazepines of use in the present invention include: alprazolam, chlordiazepoxide, clonazepam, chlorazepate. diazepam, halazepam, lorazepam, oxazepam and prazepam, and pharmaceutically acceptable salts thereof. Suitable 5-HTIA receptor agonists or antagonists of use in the present invention include, in particular, the 5-HTIA receptor partial agonists buspirone, flesinoxan, gepirone and ipsapirone, and pharmaceutically acceptable salts thereof. An example of a compound with 5-HTIA receptor antagonist/partial agonist activity is pindolol. Suitable CRF antagonists of use in the present invention include those compounds described in International Patent Specification Nos. WO 94/13643, WO 94/13644, WO 94/13661, WO 94/13676 and WO 94/13677. Another class of anti-anxiety agent of use in the present invention are compounds having muscarinic cholinergic activity. Suitable compounds in this class include ml muscarinic cholinergic receptor agonists such as those compounds described in European Patent Specification Nos. 0 709 093, 0 709 094 and 0 773 021, and International patent Specification No. WO 96/12711. Another class of anti-anxiety agent of use in the present invention are compounds acting on ion channels. Suitable compounds in this class include carbamazepine, lamotrigine and valproate, and pharmaceutically acceptable salts thereof. Particularly preferred CNS-penetrant NK-1 receptor antagonists are those described in European Patent Specification No. 0 577 394, i.e. compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein: R 1 is selected from the group consisting of: (1) hydrogen; (2) C 1 -6alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Ci-βalkoxy, (d) phenyl-d-salkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR 9 R 10 , wherein R 9 and R 10 are independently selected from: (i) hydrogen, (ii) Ci-ealkyl, (iii) hydroxy-Ci-Galkyl, and (iv) phenyl, (i) -NR 9 COR 10 , wherein R 9 and R 10 are as defined above, (j) -NR 9 CO2R 10 , wherein R 9 and R 10 are as defined above, (k) -CONR R 10 , wherein R 9 and R 10 are as defined above, (1) -COR 9 , wherein R 9 is as defined above, (m) -CO2R 9 , wherein R 9 is as defined above, (n) heterocycle, wherein the heterocycle is selected from the group consisting of: (A) benzimidazolyl, (B) benzofuranyl, (C) benzthiophenyl, (D) benzoxazolyl, (E) furanyl, (F) imidazolyl, (G) indolyl, (H) isoxazolyl, (I) isothiazolyl, (J) oxadiazolyl, (K) oxazolyl, CL) pyrazinyl, (M) pyrazolyl, (N) pyridyl, (0) pyrimidyl, (P) pyrrolyl, ( ) quinolyl, (R) tetrazolyl, (S) thiadiazolyl, (T) thiazolyl, (U) thienyl, (V) triazolyl, (W) azetidinyl, (X) 1,4-dioxanyl, 00 hexahydroazepinyl, (Z) oxanyl, (AA) piperazinyl, (AB) piperidinyl, (AC) pyrrolidinyl, (AD) tetrahydrofuranyl, and (AE) tetrahydrothienyl, and wherein the heterocylcle is unsubstituted or substituted with one or more substituent(s) selected from: (i) Ci-Galkyl, unsubstituted or substituted with halo, -CF3, -OCH3, or phenyl, (ii) Ci-oalkoxy, (iv) hydroxy, (v) thioxo, (vi) -SR 9 , wherein R 9 is as defined above, (vii) halo, (viii) cyano, (ix) phenyl, (x) trifluoromethyl, (xi) -(CH 2 )m-NR 9 R i °, wherein m is 0, 1 or 2, and R 9 and R 10 are as defined above, (xii) -NR 9 COR 10 , wherein R 9 and R 10 are as defined above, (xiii) -CONR 9 R 10 , wherein R 9 and R 10 are as defined above, (xiv) -CO2R 9 , wherein R 9 is as defined above, and (xv) -(CH2)m-OR 9 , wherein m and R 9 are as defined above; (3) C2-ealkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Ci-βalkoxy, (d) phenyl-d-salkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR 9 R 10 , wherein R 9 and R 10 are as defined above, (i) -COR 9 , wherein R 9 is as defined above, (j) -CO2R 9 , wherein R 9 is as defined above, (k) heterocycle, wherein the heterocycle is as defined above; (4) C 2 -6alkynyl; (5) phenyl, unsubstitued or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) Cι- 6 alkoxy, (c) Ci-ealkyl, (d) C2-salkenyl, (e) halo, ( ) -CN, (h) -CF 3 , (i) -(CH 2 )m-NR 9 R 10 , wherein m, R 9 and R i o are as defined above, (j) -NR 9 COR 10 , wherein R 9 and R 10 are as defined above, (k) -NR 9 CO 2 R 10 , wherein R 9 and R i o are as defined above, (1) -CONR 9 R °, wherein R 9 and R 10 are as defined above, (m) -CO2NR 9 R 10 , wherein R 9 and R 10 are as defined above, (n) -COR 9 , wherein R 9 is as defined above, (0) -CO2R 9 , wherein R 9 is as defined above; R 2 and R 3 are independently selected from the group consisting of: (1) hydrogen; (2) Ci-βalkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Ci-βalkoxy, (d) phenyl-Cι-3alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR 9 R 10 , wherein R 9 and R 10 are independently selected from: (1) -NR 9 COR °, wherein R 9 and R 10 are as defined above, (j) -NR 9 CO 2 R 10 , wherein R 9 and R i o are as defined above, (k) -CONR 9 R i °, wherein R 9 and R 10 are as defined above, (1) -COR 9 , wherein R 9 is as defined above, and ( ) -CO2R 9 , wherein R 9 is as defined above, (3) C2-ealkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Ci-Galkoxy, (d) phenyl- Cι-3alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR 9 R i ° wherein R 9 and R i o are as defined above, (i) -COR 9 , wherein R 9 is as defined above, (j) -CO2R 9 , wherein R 9 is as defined above; (4) C 2 -ealkynyl; (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) Ci-βalkoxy, (c) Ci-ealkyl, (d) C2-5alkenyl, (e) halo, ( ) -CN, (h) -CF 3 , (i) -(CH 2 ) m -NR 9 R i °, wherein m, R 9 and R i o are as defined above, CD -NR 9 COR 10 , wherein R 9 and R 10 are as defined above, (k) -NR 9 CO2R 10 , wherein R 9 and R 10 are as defined above, (1) -CONR 9 R i °, wherein R 9 and R 10 are as defined above, (m) -CO2NR 9 R 10 , wherein R 9 and R 10 are as defined above, (n) -COR 9 , wherein R 9 is as defined above, (o) -CO2R 9 , wherein R 9 is as defined above; and the groups R and R 2 may be joined together to form a heterocyclic ring selected from the group consisting of: (a) pyrrolidinyl, (b) piperidinyl, (c) pyrrolyl, (d) pyridinyl, (e) imidazolyl, (f) oxazolyl, and (g) thiazolyl, and wherein the heterocyclic ring is unsubstituted or substituted with one or more substituent(s) selected from: (i) Ci-ealkyl, (ii) oxo, (iii) Ci-calkoxy, (iv) -NR 9 R i °, wherein R 9 and R 10 are as defined above, (v) halo, and (vi) trifluoromethyl; and the groups R 2 and R 3 may be joined together to form a carbocyclic ring selected from the group consisting of: (a) cyclopentyl, (b) cyclohexyl, (c) phenyl, and wherein the carbocyclic ring is unsubstituted or substituted with one or more substituents selected from: (i) Ci.ealkyl, (ii) Ci-calkoxy, (iii) -NR 9 R i o, wherein R 9 and R i o are as defined above, (iv) halo, and (v) trifluoromethyl; and the groups R 2 and R 3 may be joined together to form a heterocyclic ring selected from the group consisting of: (a) pyrrolidinyl, (b) piperidinyl, (c) pyrrolyl, (d) pyridinyl, (e) imidazolyl, (f) furanyl, (g) oxazolyl, (h) thienyl, and (i) thiazolyl, and wherein the heterocyclic ring is unsubstituted or substituted with one or more substituent(s) selected from: (i) Ci-ealkyl, (ii) oxo, (iii) Ci-βalkoxy, (iv) -NR 9 R 10 , wherein R 9 and R i ° are as defined above, (v) halo, and (vi) trifluoromethyl; X is selected from the group consisting of: (1) -o-, (2) -S-, (3) -SO-, and (4) -SO 2 -; R 4 is selected from the group consisting of: (1) (2) -Y-d-salkyl, wherein alkyl is unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, * *(c) Ci-oalkoxy, (d) phenyl-Ci-3alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR 9 R10, wherein R 9 and RIO are as defined above, (i) -NR 9 COR 10 , wherein R 9 and R 10 are as defined above, (j) -NR 9 CO2R 10 , wherein R 9 and R ° are as defined above, (k) -CONR 9 R o, wherein R 9 and R i o are as defined above, (1) -COR 9 , wherein R 9 is as defined above, (m) -CO2R 9 , wherein R 9 is as defined above; (3) -Y-C2-6alkenyl, wherein the alkenyl is unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Ci-ealkoxy, (d) phenyl-d-βalkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR 9 R i °, wherein R 9 and R i0 are as defined above, (i) -COR 9 , wherein R 9 is as defined above, (j) -CO2R 9 , wherein R 9 is as defined above, (4) -O(CO)-phenyl, wherein the phenyl is unsubstituted or substituted with one or more of R 6 , R 7 and R 8 ; R 5 is selected from the group consisting of: (1) phenyl, unsubstituted or substituted with one or more of Rn, R i2 and R 13 ; (2) Ci-βalkyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Ci-βalkoxy, (d) phenyl-C 1 -3alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR 9 R 10 , wherein R 9 and R 10 are as defined above, (i) -NR 9 COR 10 , wherein R 9 and R 10 are as defined above, (j) -NR 9 CO2R 10 , wherein R 9 and R 10 are as defined above, (k) -CONR 9 R o, wherein R 9 and R i o are as defined above, (1) -COR 9 , wherein R 9 is as defined above, (m) -CO2R 9 , wherein R 9 is as defined above; (3) C2-6alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Ci-ealkoxy, (d) phenyl- Ci-salkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR 9 R i o, wherein R 9 and R i o are as defined above, (i) -COR 9 , wherein R 9 is as defined above, (j) -CO2R 9 , wherein R 9 is as defined above; (4) heterocycle, wherein the heterocycle is as defined above; R 6 , R 7 and R 8 are independently selected from the group consisting of: (1) hydrogen; (2) Ci-ealkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Ci-calkoxy, (d) phenyl-Ci-3alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR 9 R 10 , wherein R 9 and R 10 are as defined above, (i) -NR 9 COR 10 , wherein R 9 and R 10 are as defined above, (j) -NR 9 CO 2 R 10 , wherein R 9 and R i o are as defined above, (k) -CONR 9 R 10 , wherein R 9 and R 10 are as defined above, (1) -COR 9 , wherein R 9 is as defined above, and (m) -CO2R 9 , wherein R 9 is as defined above; (3) C2-ealkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Ci-calkoxy, (d) phenyl-Cι-3alkoxy, (e) phenyl, ( ) -CN, (g) halo, (h) -CONR 9 R 10 wherein R 9 and R 10 are as defined above, (i) -COR 9 wherein R 9 is as defined above, (j) -CO2R 9 , wherein R 9 is as defined above; (4) C2-ealkynyl; (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) Ci-calkoxy, (c) Cι- G alkyl, (d) C2-5alkenyl, (e) halo, (f) -CN, (h) -CF 3 , (i) -(CH 2 )m-NR 9 R 10 , wherein m, R 9 and R i o are as defined above, (j) -NR 9 COR 10 , wherein R 9 and R i o are as defined above, (k) -NR 9 CO 2 R 10 , wherein R 9 and R i o are as defined above, (1) -CONR 9 R i °, wherein R 9 and R i o are as defined above, (m) -CO2NR 9 R i °, wherein R 9 and R ° are as defined above, (n) -COR 9 , wherein R 9 is as defined above; (o) -CO2R 9 , wherein R 9 is as defined above; (6) halo, (7) -CN, (8) -CF 3 , (10) -SR 14 , wherein R 14 is hydrogen or Ci-salkyl, (11) -SOR 14 , wherein R 14 is as defined above, (12) -SO2R 14 , wherein R 14 is as defined above, (13) NR 9 COR 10 , wherein R 9 and R i o are as defined above, (14) CONR 9 COR 10 , wherein R 9 and R 10 are as defined above, (15) NR 9 R 10 , wherein R 9 and R 10 are as defined above, (16) NR 9 CO 2 R 10 , wherein R 9 and R i o are as defined above, (17) hydroxy, (18) d-calkoxy, (19) COR 9 , wherein R 9 is as defined above, (20) CO2R 9 , wherein R 9 is as defined above, Rn, R i2 and R 13 are independently selected from the definitions of R 6 , R 7 and R 8 , or -OX; Y is selected from the group consisting of: (1) a single bond, (2) -O-, (3) -S-, (4) -CO-, (6) -CHR 15 -, and (7) -CR 15 R 16 -, wherein R 15 and R 1G are independently selected from the group consisting of: (a) Ci-calkyl, unsubstituted or substituted with one or more of the substituents selected from: (i) hydroxy, (ii) oxo, (iii) Ci-calkoxy, (iv) phenyl-Cι-3alkoxy, (v) phenyl, (vii) halo, (viii) -NR 9 R 10 , wherein R 9 and R 10 are as defined above, (ix) -NR 9 COR i °, wherein R 9 and R i o are as defined above, (x) -NR 9 C0 2 R 10 , wherein R 9 and R 10 are as defined above, (xi) -CONR O R 10 , wherein R 9 and R 10 are as defined above, (xii) -COR 9 , wherein R 9 is as defined above, and (xiii) -CO2R 9 , wherein R 9 is as defined above; (b) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (1) hydroxy, (ii) Ci-calkoxy, (iϋ) Ci-calkyl, (iv) C2-5alkenyl, (v) halo, (vi) -CN, (viii) -CF 3 , (ix) -(CH 2 )m-NR 9 R i o, wherein m, R 9 and R i o are as defined above, (x) -NR 9 COR i °, wherein R 9 and R 10 are as defined above, (xi) -NR 9 CO 2 R 10 , wherein R 9 and R 10 are as defined above, (xii) -CONR 9 R 10 , wherein R 9 and R i ° are as defined above, (xiii) -CO2NR 9 R 10 , wherein R 9 and R 10 are as defined above, (xiv) -COR 9 , wherein R 9 is as defined above, and (xv) -CO2R 9 , wherein R 9 is as defined above; Z is selected from: (1) hydrogen, (2) Cι- 4 alkyl. and (3) hydroxy, with the proviso that if Y is -O-, Z is other than hydroxy, or if Y is -CHR 15 -, then Z and R i5 may be joined together to form a double bond. Particularly preferred compounds of formula (I) are those wherein: R i is selected from the group consisting of: (1) Ci-calkyl, substituted with one or more of the substituents selected from: (a) heterocycle, wherein the heterocycle is selected from the group consisting of: (A) benzimidazolyl, (B) imidazolyl, (C) isoxazolyl, (D) isothiazolyl, (E) oxadiazolyl, (F) pyrazinyl, (G) pyrazolyl, (H) pyridyl, (I) pyrrolyl, (J) tetrazolyl, (K) thiadiazolyl, (L) triazolyl, and (M) piperidinyl, and wherein the heterocycle is unsubstituted or substituted with one or more substituent(s) selected from: (i) Ci-calkyl, unsubstituted or substituted with halo, -CF3, -OCH3, or phenyl, (ii) Ci-calkoxy, (iii) oxo, (iv) thioxo, (v) cyano, (vii) phenyl, (viii) hydroxy, (ix) trifluoromethyl, (x) -(CH 2 ) m -NR R i o, wherein m is 0, 1 or 2, and R 9 and R i o areindependently selected from: (I) hydrogen, (II) Ci-calkyl, (III) hydroxyCi-calkyl, and (IV) phenyl, (xi) -NR 9 COR i °, wherein R 9 and R i are as defined above, and (xii) -CONR 9 R i °, wherein R 9 and R i o are as defined above, R 2 and R 3 are independently selected from the group consisting of: (1) hydrogen; (2) Ci-calkyl (3) C2-calkenyl, and (5) phenyl; X is -O-; R 4 is R 5 is phenyl, unsubstituted or substituted with halo; R G , R 7 and R 8 are independently selected from the group consisting of: (1) hydrogen, (2) Ci-calkyl, (3) halo, and (4) -CF 3 ; Y is -O-; and Z is hydrogen or Cι-4alkyl; and pharmaceutically acceptable salts thereof. A particularly preferred compound of formula (I) is 2-(R)-(l-(R)-(3,5- bis(trifluoromethyl)pheny)lethoxy)-3-(S)-(4-fluorophenyl)-4-(3-(5-oxo- lH,4H-l,2,4-triazolo)methyl)morpholine; or a pharmaceutically acceptable salt thereof. Further preferred CNS-penetrant NK-1 receptor antagonists are those described in International (PCT) Patent Specification No. WO 95/18124, i.e. compounds of formula (II): or a pharmaceutically acceptable salt or prodrug thereof, wherein R 1 is hydrogen, halogen, Ci-calkyl, Ci-calkoxy, CF3, NO2, CN, SR a , SOR a , SO 2 R a , CO 2 R a , CONR a R b , C 2 -calkenyl, C 2 - 6 alkynyl or Cι- alkyl substituted by Cι-4alkoxy, where R a and R b each independently represent hydrogen or Cι-4alkyl; R 2 is hydrogen, halogen, Ci-βalkyl, Ci-calkoxy substituted by Cι-4alkoxy or CF3; R 3 is hydrogen, halogen or CF3; R 4 is hydrogen, halogen, Ci-ealkyl, Ci-calkoxy, CF 3 , NO2, CN, SR a , SOR a , SO 2 R a , CO 2 R a , CONR a R b , C 2 -ealkenyl, C 2 -calkynyl or Cι- alkyl substituted by d^alkoxy, where R a and R b each independently represent hydrogen or Cι-4alkyl; R 5 is hydrogen, halogen, Ci-calkyl, Ci-βalkoxy substituted by Cι- 4 alkoxy or CF3; R 6 is a 5-membered or 6-membered heterocyclic ring containing 2 or 3 nitrogen atoms optionally substituted by =0, =S or a Cι-4alkyl group, and optionally substituted by a group of the formula ZNR ' R 8 where Z is Ci-calkylene or C3-ccycloalkylene; R 7 is hydrogen, Cι-4alkyl, C3-7cycloalkyl or C3-7cycloalkylCι- 4 alkyl, or C2-4alkyl substituted by Cι-4alkoxy or hydroxyl; R 8 is hydrogen, Cι-4alkyl, C3-7cycloalkyl or C3-7cycloalkylCι-4alkyl, or C2-4alkyl substituted by one or two substituents selected from Cι-4alkoxy, hydroxyl or a 4, 5 or 6 membered heteroaliphatic ring containing one or two heteroatoms selected from N, O and S; or R 7 , R 8 and the nitrogen atom to which they are attached form a heteroaliphatic ring of 4 to 7 ring atoms, optionally substituted by a hydroxy group, and optionally containing a double bond, which ring may optionally contain an oxygen or sulphur ring atom, a group S(O) or S(O) 2 or a second nitrogen atom which will be part of a NH or NR C moiety where R c is Cι-4alkyl optionally substituted by hydroxy or Cι-4alkoxy; or R 7 , R 8 and the nitrogen atom to which they are attached form a non-aromatic azabicyclic ring system of 6 to 12 ring atoms; or Z, R 7 and the nitrogen atom to which they are attached form a heteroaliphatic ring of 4 to 7 ring atoms which may optionally contain an oxygen ring atom; R 9a and R 9b are each independently hydrogen or Cι-4alkyl, or R 9a and R 9b are joined so, together with the carbon atoms to which they are attached, there is formed a C5-7 ring; X is an alkylene chain of 1 to 4 carbon atoms optionally substituted by oxo; and Y is a Cι-4alkyl group optionally substituted by a hydroxyl group; with the proviso that if Y is Cι-4alkyl, R 6 is susbstituted at least by a group of formula ZNR 7 R 8 as defined above. Particularly preferred compounds of formula (II) are those of formula (Ila) and pharmaceutically acceptable salts thereof: (Ila) wherein: A i is fluorine or CF3; A 2 is fluorine or CF3; A 3 is fluorine or hydrogen; and X, Y and R 6 are as defined in relation to formula (II). Particularly preferred compounds of formula (II) include: 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(5-(dimethylamino) methyl- 1, 2, 3-triazol-4-yl)methyl-3-(S)-phenylmorpholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(5-(dimethylamino) methyl- 1, 2, 3-triazol-4-yl)methyl-3-(S)-(4-fluorophenyl)morpholine; and pharmaceutically acceptable salts thereof. Further preferred CNS-penetrant NK-1 receptor antagonists are those described in European Patent Specification No. WO 95/23798, i.e. compounds of formula (III): or a pharmaceutically acceptable salt thereof, wherein: R 2 and R 3 are independently selected from the group consisting of: (1) hydrogen, (2) Ci-calkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Ci-calkoxy, (d) phenyl-Cι-3alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR 9 R 10 , wherein R 9 and R 10 are independently selected from: (I) hydrogen, (ii) Ci-calkyl, (iii) hydroxy- Ci-calkyl, and (iv) phenyl, (i) -NR 9 COR i °, wherein R 9 and R 10 are as defined above, (j) -NR 9 CO2R 10 , wherein R 9 and R 10 are as defined above, (k) -CONR 9 R i °, wherein R 9 and R 10 are as defined above, (1) -COR 9 , wherein R 9 is as defined above, and (m) -CO2R 9 , wherein R 9 is as defined above; (3) C2-6alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Ci-calkoxy, (d) phenyl-Cι-3alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR 9 R i o wherein R 9 and R i o are as defined above, (i) -COR 9 wherein R 9 is as defined above, (j) -CO2R 9 , wherein R 9 is as defined above; (4) C 2 -6alkynyl; (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) d-calkoxy, (c) Ci-calkyl, (d) C 2 -5alkenyl, (e) halo, (f) -CN, (h) -CF 3 , (i) -(CH 2 )m-NR 9 R i o, wherein m, R 9 and R i are as defined above, (j) -NR COR 10 , wherein R 9 and R i o are as defined above, (k) -NR 9 CO 2 R 10 , wherein R 9 and R i o are as defined above, (1) -CONR 9 R i °, wherein R 9 and R i o are as defined above, (m) -CO 2 NR 9 R i °, wherein R 9 and R i o are as defined above, (n) -COR 9 , wherein R 9 is as defined above, (0) -CO2R 9 , wherein R 9 is as defined above; and the groups R 2 and R 3 may be joined together to form a carbocyclic ring selected from the group consisting of: (a) cyclop entyl, (b) cyclohexyl, (c) phenyl, and wherein the carbocyclic ring is unsubstituted or substituted with one or more substituents selected from: (1) Ci-calkyl, (ii) Ci-calkoxy, (iii) -NR 9 R i °, wherein R 9 and R ° are as defined above, (iv) halo, and (v) trifluoromethyl; and the groups R 2 and R 3 may be joined together to form a heterocyclic ring selected from the group consisting of: (a) pyrrolidinyl, (b) piperidinyl, (c) pyrrolyl, (d) pyridinyl, (e) imidazolyl, (f) furanyl, (g) oxazolyl, (h) thienyl, and (i) thiazolyl, and wherein the heterocyclic ring is unsubstituted or substituted with one or more substituent(s) selected from: (i) Ci-calkyl, (ii) oxo, (iii) Ci-calkoxy, (iv) -NR 9 R i °, wherein R 9 and R 10 are as defined above, (v) halo, and (vi) trifluoromethyl; R 6 , R 7 and R 8 are independently selected from the group consisting of: (1) hydrogen; (2) Ci-calkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Ci-calkoxy, (d) phenyl-Cι-3alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR 9 R 10 , wherein R 9 and R 10 are as defined above, (i) -NR 9 COR 10 , wherein R 9 and R o are as defined above, (j) -NR 9 CO 2 R 10 , wherein R 9 and R i o are as defined above, (k) -CONR 9 R i °, wherein R 9 and R i o are as defined above, (1) -COR 9 , wherein R 9 is as defined above, and (m) -CO2R 9 , wherein R 9 is as defined above; (3) C2-6alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Ci-βalkoxy, (d) phenyl-Cι-3alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR 9 R 10 wherein R 9 and R i o are as defined above, (i) -COR 9 wherein R 9 is as defined above, (j) -CO2R 9 , wherein R 9 is as defined above; (4) C2-6alkynyl; (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) Ci-Galkoxy, (c) Ci-calkyl, (d) C 2 -5alkenyl, (e) halo, ( ) -CN, (h) -CF 3 , (i) -(CH 2 ) m -NR 9 R i o, wherein m, R 9 and R 10 are as defined above, (j) -NR 9 COR i °, wherein R 9 and R i o are as defined above, (k) -NR 9 CO 2 R 10 , wherein R 9 and R i o are as defined above, (1) -CONR 9 R 10 , wherein R 9 and R o are as defined above, (m) -CO2NR 9 R 10 , wherein R 9 and R 10 are as defined above, (n) -COR 9 , wherein R 9 is as defined above, (o) -CO2R 9 , wherein R 9 is as defined above; (6) halo, (7) -CN, (8) -CF 3 , (10) -SR 14 , wherein R 14 is hydrogen or Ci-salkyl, (11) -SOR 14 , wherein R is as defined above, (12) -SO2R 14 , wherein R w is as defined above, (13) NR 9 COR i °, wherein R 9 and R i o are as defined above, (14) CONR 9 COR 10 , wherein R 9 and R i o are as defined above, (15) NR 9 R i °, wherein R 9 and R i ° are as defined above, (16) NR 9 CO 2 R 10 , wherein R 9 and R i o are as defined above, (17) hydroxy, (18) Ci-calkoxy, (19) COR 9 , wherein R 9 is as defined above, (20) CO2R 9 , wherein R 9 is as defined above, (21) 2-pyridyl, (22) 3-pyridyl, (23) 4-pyridyl, (24) 5-tetrazolyl, (25) 2-oxazolyl, and (26) 2-thiazolyl; Rn, R 12 and R 13 are independently selected from the definitions of R G , R 7 and R 8 , or -OX; A is selected from the group consisting of: (1) Ci-calkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Ci-calkoxy, (d) phenyl-Cι-3alkoxy, (e) phenyl, (f) -CN, (g) halo, wherein halo is fluoro, chloro, bromo or iodo, (h) -NR 9 R 10 , wherein R 9 and R ° are as defined above, (i) -NR 9 COR 10 , wherein R 9 and R i o are as defined above, (j) -NR 9 CO 2 R 10 , wherein R 9 and R i o are as defined above, (k) -CONR 9 R °, wherein R 9 and R i o are as defined above, (1) -COR 9 , wherein R 9 is as defined above, and (m) -CO2R 9 , wherein R 9 is as defined above; (2) C2-calkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Ci-Galkoxy, (d) phenyl-Cι-3alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR 9 R ° wherein R 9 and R 10 are as defined above, (i) -COR 9 wherein R 9 is as defined above, and (j) -CO2R 9 , wherein R 9 is as defined above; and (3) C 2 -calkynyl; B is a heterocycle, wherein the heterocycle is selected from the group consisting of: and wherein the heterocycle may be substituted in addition to -X with one or more substituent(s) selected from: (i) Ci-calkyl, unsubstituted or substituted with halo, -CF3, -OCH3, or phenyl, (ii) Ci-calkoxy, (iii) oxo, (iv) hydroxy, (v) thioxo, (vi) -SR 9 , wherein R 9 is as defined above, (vii) halo, (viii) cyano, (ix) phenyl, (x) trifluoromethyl, (xi) -(CH 2 )m-NR 9 R i °, wherein m is 0, 1 or 2, and R 9 and Rio are as defined above, (xii) -NR 9 COR °, wherein R 9 and R i ° are as defined above, (xiii) -CONR 9 R °, wherein R 9 and R 10 are as defined above, (xiv) -CO2R 9 , wherein R 9 is as defined above, and (xv) -(CH2)m-OR 9 , wherein m and R 9 are as defined above; p is 0 or 1; X is selected from: (a) -PO(OH)O" • M + , wherein M + is a pharmaceutically acceptable monovalent counterion, (b) -PO(0-) 2 • 2M + , (c) -PO(O " )2 ' D 2+ , wherein D 2+ is a pharmaceutically acceptable divalent counterion, (d) -CH(R 4 )-PO(OH)O" • M + , wherein R 4 is hydrogen or Ci-salkyl, (e) -CH(R 4 )-PO(O-) 2 • 2M + , (f) -CH(R 4 )-PO(O-) 2 • D 2+ , (h) -CH(R )-SO 3 - • M + , (i) -CO-CH2CH2-CO2- • M + , (j) -CH(CH 3 )-O-CO-R 5 , wherein R 5 is selected from the group consisting of: ( ) .NH 3 M " ' O ' (ϋi) ' O CO„ " M + (k) hydrogen, with the proviso that if p is 0 and none of R 11 , R 12 or R 13 are -OX, then X is other than hydrogen; Y is selected from the group consisting of: (1) a single bond, (2) -O-, (3) -S-, (4) -CO-, (5) -CH 2 -, (6) -CHR 15 -, and (7) -CR i5 R 16 -, wherein R i5 and R x6 are independently selected from the group consisting of: (a) Ci-βalkyl, unsubstituted or substituted with one or more of the substituents selected from: (i) hydroxy, (ii) oxo, (iii) Ci-calkoxy, (iv) phenyl- Ci-3alkoxy, (v) phenyl, (vi) -CN, (vii) halo, (viii) -NR 9 R i °, wherein R 9 and R 10 are as defined above, (ix) -NR 9 COR 10 , wherein R 9 and R i o are as defined above, (x) -NR 9 CO2R 10 , wherein R 9 and R i ° are as defined above, (xi) -CONR 9 R 10 , wherein R 9 and R 10 are as defined above, (xii) -COR 9 , wherein R 9 is as defined above, and (xiii) -CO2R 9 , wherein R 9 is as defined above; (b) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (i) hydroxy, (ii) Ci-calkoxy, (iii) Ci-calkyl, (iv) C2-5alkenyl, (v) halo, (vi) -CN, (viii) -CF 3 , (ix) -(CH 2 )m-NR 9 R i o, wherein m, R 9 and R i o are as defined above, (x) -NR 9 COR 10 , wherein R 9 and R 10 are as defined above, (xi) -NR 9 CO2R 10 , wherein R 9 and R 10 are as defined above, (xii) -CONR 9 R i °, wherein R 9 and R 10 are as defined above, (xiii) -CO2NR 9 R i °, wherein R 9 and R 10 are as defined above, (xiv) -COR 9 , wherein R 9 is as defined above, and (xv) -CO2R 9 , wherein R 9 is as defined above; Z is selected from: (1) hydrogen, (2) Ci-calkyl, and (3) hydroxy, with the proviso that if Y is -O-, Z is other than hydroxy, or if Y is -CHR 15 -, then Z and R 15 may be joined together to form a double bond. Particularly preferred compounds of formula (III) are those wherein: R 2 and R 3 are independently selected from the group consisting of: (1) hydrogen, (2) Ci-calkyl, (3) C2-6alkenyl, and (4) phenyl; R 6 , R 7 and R 8 are independently selected from the group consisting of: (1) hydrogen, (2) Cι- 6 alkyl, (3) fluoro, (4) chloro, (5) bromo, (6) iodo, and (7) -CF 3 ; Rn, R 12 and R 13 are independently selected from the group consisting of: (1) fluoro, (2) chloro, (3) bromo, and (4) iodo; A is unsubstituted l-calkyl; B is selected from the group consisting of: p is 0 or 1; X is selected from: (a) -PO(OH)O " • M + , wherein M + is a pharmaceutically acceptable monovalent counterion, (b) -PO(0-) 2 • 2M + , (c) -PO(O " ) 2 • D 2+ , wherein D 2+ is a pharmaceutically acceptable divalent counterion, (d) -CH(R 4 )-PO(OH)O " • M + , wherein R 4 is hydrogen or Cι- 3 alkyl. (e) -CH(R 4 )-PO(O") 2 • 2M + , (f) -CH(R )-PO(O-) 2 • D 2+ , (i) -CO-CH2CH2-CO2- • M + , (j) -CH(CH 3 )-O-CO-R 5 , wherein R 5 is selected from the group consisting of: (1) . NH 3 M 0 ' H 2 + M (11) ' O ' ~ 0H (m) 0 C0 M a CO, (v) O NH, Y is -O-; Z is hydrogen or Ci oalkyl; and pharmaceutically acceptable salts thereof Particularly preferred compounds of formula (III) include: (1) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-4-(3-(5-oxo- lH,4H-l,2,4-triazolo)methyl)morpholine N-oxide; (2) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-4-(3-(4- (ethoxycarbonyloxy-l-ethyl)-5-oxo-lH-l,2,4- triazolo)methyl)morpholine; (3) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(3-(4-monophosphoryl-5-oxo-lH-l,2,4- triazolo) me thy 1) morp holine ; (4) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(3-(l-monophosphoryl-5-oxo-lH- 1,2,4- triazolo)methyl)morp holine; (5) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(3-(2-monophosphoryl-5-oxo-lH-l,2,4- triazolo)methyl)morp holine; (6) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(3-(5-oxyphosphoryl-lH-l,2,4- triazolo)methyl)morp holine; (7) 2-(S)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(3-(l-monophosphoryl-5-oxo-4H-l,2,4- triazolo)methyl)morpholine; and pharmaceutically acceptable salts thereof. Further preferred CNS-penetrant NK-1 receptor antagonists are those described in European Patent Specification No. WO 96/05181, i.e. compounds of formula (IV): wherein X is a group of the formula NR 6 R 7 or a C- or N-linked imidazolyl ring; Y is hydrogen or Cι-4alkyl optionally substituted by a hydroxy group; R i is hydrogen, halogen, Ci-calkyl, Ci-calkoxy, CF 3 , NO 2 , CN, SR a , SOR a , SO 2 R a , CO 2 R a , CONR a R b , C 2 -calkenyl, C^alkynyl or Cι- alkyl substituted by Cι-4alkoxy, wherein R a and R b each independently represent hydrogen or Cι-4alkyl; R 2 is hydrogen, halogen, Ci-calkyl, Ci-calkoxy substituted by Cι-4alkoxy or CF3; R 3 is hydrogen, halogen or CF3; R 4 is hydrogen, halogen, Ci-calkyl, Ci-calkoxy, hydroxy, CF 3 , NO2, CN, SR a , SOR a , SO 2 R a , CO 2 R a , CONR a R t \ C 2 - 6 alkenyl, C 2 -calkynyl or Cι-4alkyl substituted by Cι-4alkoxy, wherein R a and R b are as previously defined; R 5 is hydrogen, halogen, Ci-calkyl, Ci-Galkoxy substituted by Cι. 4 alkoxy or CF 3 ; R 6 is hydrogen, Ci-calkyl, C3-7cycloalkyl, C3-7cycloalkylCι-4alkyl, phenyl, or C2-4alkyl substituted by Cι-4alkoxy or hydroxy; R 7 is hydrogen, Ci-calkyl, C3-7cycloalkyl, C3-7cycloalkylCι oalkyl, phenyl, or C2-4alkyl substituted by one or two substituents selected from Cι-4alkoxy, hydroxy or a 4, 5 or 6 membered heteroaliphatic ring containing one or two heteroatoms selected from N, 0 and S; or R 6 and R 7 , together with the nitrogen atom to which they are attached, form a saturated or partially saturated heterocyclic ring of 4 to 7 ring atoms, which ring may optionally contain in the ring one oxygen or sulphur atom or a group selected from NR 8 , S(O) or S(O)2 and which ring may be optionally substituted by one or two groups selected from hydroxyCi-4alkyl, Cι-4alkoxyCi-4alkyl, oxo, COR a or CO2R a where R a is as previously defined; or R G and R 7 together with the nitrogen atom to which they are attached, form a non-aromatic azabicyclic ring system of 6 to 12 ring atoms; R 8 is hydrogen, Cι-4alkyl, hydroxyCι-4alkyl or Cι-4alkoxyCι-4alkyl; and R 9a and R 9b are each independently hydrogen or Cι-4alkyl, or R 9a and R 9b are joined so, together with the carbon atoms to which they are attached, there is formed a C5-7 ring; and pharmaceutically acceptable salts thereof. Particularly preferred compounds of formula (IV) are those of formula (IVa) and pharmaceutically acceptable salts thereof: wherein A is fluorine or CF3; A 2 is fluorine or CF3; A 3 is fluorine or hydrogen; and X and Y are as defined in relation to formula (I). Specific compounds of formula (IV) of use in the present invention include: 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 4-(4-morpholinobut-2-yn-yl)morp holine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-N,N- dimethylaminobut-2-yn-yl)-3-(S)-(4-fluorophenyl)morpholine; 4-(4-azetidinylbut-2-yn-yl)-2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(S)-(4-fluorophenyl)morpholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 4-(4-imidazolylbut-2-yn-yl)morpholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 4-(4-(N-methylpiperazinyl)but-2-yn-yl)morp holine; 4-(4-bis(2-methoxyethyl)aminobut-2-yn-yl)-2-(R)-(l-(R)-(3,5- bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)morpholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 4-(4-pyrrolidinobut-2-yn-yl)morpholine; 3-(S)-(4-fluorophenyl)-2-(R)-(l-(R)-(3-fluoro-5-(trιfluoromethyl)phenyl) ethoxy)-4-(4-morpholinobut-2-yn-yl)morp holine; 3-(S)-(4-fluorophenyl)-4-(4-morpholinobut-2-yn-yl)-2-(R)-(l-(R)-(3- (trifluoromethyl)phenyl)ethoxy)morpholine; 4-(4-azetidinylbut-2-yn-yl)-3-(S)-(4-fluorophenyl)-2-(R)-(l-(R)-(3- (trifluoromethyl)phenyl)ethoxy)morp holine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-(N-(2- methoxyethyl)-N-methyl)aminobut-2-yn-yl)-3-(S)-phenylmorpholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-(N-cyclopropyl-N- (2-methoxyethyl)amino)but-2-yn-yl)-3-(S)-phenylmorpholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-(N-ιsopropyl-N-(2- methoxyethyl)amino)but-2-yn-yl)-3-(S)-phenylmorp holine; 4-(4-(N,N-dimethylamino)but-2-yn-yl)-3-(S)-(4-fluorophenyl)-2-(R)-(l-(S)- (3-fluoro-5-(trifluoromethyl)phenyl-2-hydroxyethoxy)morpholine; 4-(4-azetidmylbut-2yn-yl)-3-(S)-(4-fluorophenyl)-2-(R)-(l-(S)-(3-fluoro-5- (trifluoromethyl)phenyl)-2-hydroxyethoxy)morpholine; 2-(R)-(l-(S)-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethoxy)-4-(4-(N,N- dimethylamino)but-2-yn-yl)-3-(S)-(4-fluorophenyl)morp holine; 4-(4-azetidinylbut-2-yn-yl)-2-(R)-(l-(S)-(3,5-bis(trifluoromethyl)phenyl-2- hydroxyethoxy)-3-(S)-(4-fluorophenyl)morp holine; 4-(4-N-bis(2-methoxy)ethyl-N-methylamino)but-2-yn-yl)-2-(R)-(l-(R)-(3,5- bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)morphohne; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 4-(4-(2-(S)-(methoxymethyl)pyrrolidino)but-2-yn-yl)morp holine; 4-(4-(7-azabicyclo[2.2.1]heptano)but-2-yn-yl)-2-(R)-(l-(R)-(3,5- bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)morpholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4- diisopropylaminobut-2-yn-yl)-3-(S)-(4-fluorophenyl)morpholine; 2-(R)-(l-(R)-(3-fluoro-5-(trifluoromethyl)phenyl)ethoxy)-4-(4-(2-(S)- (methoxymethyl)pyrrolidino)but-2-yn-yl)-3-(S)-phenylmorpholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 4-(4-(2-(S)-(hydroxymethyl)pyrrolidino)but-2-yn-yl)morpholine; and pharmaceutically acceptable salts thereof. Further preferred CNS-penetrant NK-1 receptor antagonists are those described in European Patent Specification No. WO 96/07649, i.e. compounds of formula (V): wherein R is hydrogen, halogen, Ci-calkyl, Ci-calkoxy, CF 3 , N0 2 , CN, CO 2 R a CONR a R b , C2-calkenyl, C2-ealkynyl or Cι-4alkyl substituted by Cι-4alkoxy, and wherein R a and R b are each independently hydrogen or Cι-4alkyl; R 2 is hydrogen, halogen, Ci-calkyl, Ci-calkoxy substituted by Cι-4alkoxy or CF3; R 3 is hydrogen, halogen or CF3; R 4 is hydrogen, halogen, Ci-calkyl, Ci-calkoxy, hydroxy, CF 3 , NO2, CN, CO 2 R a , CONR a R b , C 2 -ealkenyl, C 2 -calkynyl or Cι. 4 alkyl substituted by Cι-4alkoxy, wherein R and R b are as previously defined; R 5 is hydrogen, halogen, Ci-calkyl, Ci-calkoxy substituted by Cι-4alkoxy or CF3; Ro is hydrogen, Ci-calkyl, C3-7cycloalkyl, C3-7cycloalkylCι-4alkyl, phenyl, or C2-4alkyl substituted by Cι-4alkoxy or hydroxy; R 7 is hydrogen, Ci-calkyl, C3-7cycloalkyl, C3-7cycloalkylCι-4alkyl, phenyl, C2-4alkyl substituted by Cι-4alkoxy or hydroxy, or the group C(=NR c )NR a R b , where R a and R b are as previously defined and R c is hydrogen, Ci-calkyl, CN or COR a ; or R 6 and R 7 , together with the nitrogen atom to which they are attached, form a saturated heterocyclic ring of 4 to 7 ring atoms which may optionally contain in the ring one oxygen or sulphur atom or a group selected from NR 8 , S(O) or S(O)2 and which ring may be optionally substituted by one or two groups selected from phenyl, benzyl, hydroxyCι-4alkyl, Cι-4alkoxyCι-4alkyl, hydroxy, oxo, COR a or CO2R a where R a is as previously defined; or R 6 and R 7 , together with the nitrogen atom to which they are attached, form a piperidino ring substituted by a spiro-fused indene or indoline group, each of which may be unsubstituted or substituted on any available carbon atom by a group selected from Ci-calkyl, Ci-calkoxy, hydroxy, halogen, cyano, trifluoromethyl, SO2Ci-ealkyl, NR a R b , NR a COR b or CONR a R b ; or, in the case of an indoline group, on the nitrogen atom by a group selected from Ci-ealkyl, C3-7cycloalkyl, C3-7cycloalkylCι-4alkyl, phenylCι- 4 alkyl, CO 2 R a , CONR a R b , SOR a or SO 2 R a , where R a and R are as previously defined; R 8 is hydrogen, Ci-4alkyl, hydroxyCι-4alkyl or Cι-4alkoxyCι-4alkyl; R 9a and R 9b are each independently hydrogen or Cι-4alkyl, or R 9a and R 9b are joined so, together with the carbon atoms to which they are attached, there is formed a C5-7 ring; X is selected from -CH2CH2-, -COCH2- or -CH2CO-; and Y is hydrogen, or Cι-4alkyl optionally substituted by a hydroxyl group; or a pharmaceutically acceptable salt thereof. Particularly preferred compounds of formula (V) are those of formula (Va) and pharmaceutically acceptable salts thereof: wherein A 1 is hydrogen, fluorine or CF3; A 2 is fluorine or CF3; A 3 is fluorine or hydrogen; and X, Y, R 6 and R 7 are as defined in relation to formula (V). Specific compounds of formula (V) of use in the present invention include: 4-(2-aminoethyl)-2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)- (4-fluorophe ny 1) morp holine ; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 4-(2-pyrrolidinoethyl)morpholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 4-(2-morpholinoethyl)morpholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(2-(2'-(S)- carboxypyrrolidino)ethyl)-3-(S)-(4-fluorophenyl)morp holine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 4-(2-(2'-(R)-hydroxymethylpyrrolidino)ethyl)morphohne; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(2-(4'-carbomethoxy- 2'-oxopyrrolidino)ethyl)-3-(S)-(4-fluorophenyl)morphohne; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(2-(N'-carboethoxy)- guanidino)ethy 1) - 3 - (S) - (4-fluoropheny l)morp holine ; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(2-(4- phenylpiperidino)ethyl)morpholine; 3-(S)-phenyl-4-(2-(4-phenylpiperidino)ethyl)-2-(R)-(l-(R)-(3- (trifluoromethyl)phenyl)ethoxy)morpholine; 2-(R)-(l-(R)-(3-fiuoro-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(2- (spiro(indene-3',4-piperidino))ethyl)morp holine; 2-(R)-(l-(R)-(3-fluoro-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(2- (4-phenylpiperidino)ethyl)morpholine; 2-(R)-(l-(R)-(3-fluoro-5-(trifluoromethyl)phenyl)ethoxy)-4-(2-(l'- methylsulfonyl-spiro(indoline-3',4-piperidino))ethyl)-3-(S)- phenylmorp holine ; 2-(R)-(l-(R)-(3-fluoro-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(2- (4-piperidino)ethyl)morpholine; 2-(S)-(3,5-bis(trifluoromethyl)phenyl)methyloxy)-3-(S)-phenyl-4-(2-(4- phenylpiperidino)ethyl)morp holine; 4-(2-(4-benzylpiperidino)ethyl)-2-(S)-(3,5-bis(trifluoromethyl)phenyl)- methy loxy) - 3 - (S) -phenylmorpholine ; and pharmaceutically acceptable salts thereof. The preferred compounds of formulae (I), (II), (III), (IV) and (V) will have the 2- and 3-substituents on the morpholine ring in the cis arrangement, the preferred stereochemistry being as shown in the following general formula: Where the benzyloxy moiety is α-substituted, the preferred stereochemistry of the α-carbon is either (B) when the substituent is an alkyl (e.g. methyl) group or (S) when the substituent is a hydroxyalkyl (e.g. hydroxy methyl) group. Unless otherwise defined herein, suitable alkyl groups include straight-chained and branched alkyl groups containing from 1 to 6 carbon atoms. Typical examples include methyl and ethyl groups, and straight- chained or branched propyl and butyl groups. Particular alkyl groups are methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl and tert-butyl. Unless otherwise defined herein, suitable alkenyl groups include straight-chained and branched alkenyl groups containing from 2 to 6 carbon atoms. Typical examples include vinyl and allyl groups. Unless otherwise defined herein, suitable alkynyl groups include straight-chained and branched alkynyl groups containing from 2 to 6 carbon atoms. Typical examples include ethynyl and propargyl groups. Unless otherwise defined herein, suitable cycloalkyl groups include groups containing from 3 to 7 carbon atoms. Particular cycloalkyl groups are cyclopropyl and cyclohexyl. Unless otherwise defined herein, suitable aryl groups include phenyl and naphthyl groups. A particular aryl-C j 6 alkyl, e.g. phenyl-Ci-calkyl, group is benzyl. Unless otherwise defined herein, suitable heteroaryl groups include pyridyl, quinolyl, isoquinolyl, pyridazinyl, pyrimidinyl, pyrazinyl, pyranyl, furyl, benzofuryl, thienyl, benzthienyl, imidazolyl, oxadiazolyl and thiadiazolyl groups. The term "halogen" as used herein includes fluorine, chlorine, bromine and iodine. The compounds of use in this invention may have one or more asymmetric centres and can therefore exist as enantiomers and possibly as diastereoisomers. It is to be understood that the present invention relates to the use of all such isomers and mixtures thereof. Suitable pharmaceutically acceptable salts of the CNS-penetrant NK-1 receptor antagonists of use in the present invention include acid addition salts which may, for example, be formed by mixing a solution of the compound with a solution of a pharmaceutically acceptable non-toxic acid such as hydrochloric acid, fumaric acid, maleic acid, succinic acid, acetic acid, citric acid, tartaric acid, carbonic acid, phosphoric acid or sulphuric acid. Salts of amine groups may also comprise the quaternary ammonium salts in which the amino nitrogen atom carries an alkyl, alkenyl, alkynyl or aralkyl group. Where the compound carries an acidic group, for example a carboxylic acid group, the present invention also contemplates salts thereof, preferably non-toxic pharmaceutically acceptable salts thereof, such as the sodium, potassium and calcium salts thereof. Suitable pharmaceutically acceptable salts of the antidepressant or anti-anxiety agent of use in the present invention include those salts described above in relation to the salts of CNS-penetrant NK-1 receptor antagonists. The present invention accordingly provides the use of a CNS- penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V) and an antidepressant or anti-anxiety agent for the manufacture of a medicament for the treatment or prevention of depression and/or anxiety. The present invention also provides a method for the treatment or prevention of depression and/or anxiety, which method comprises administration to a patient in need of such treatment an amount of a CNS-penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V) and an amount of an antidepressant or anti-anxiety agent such that together they give effective relief. In a further aspect of the present invention, there is provided a pharmaceutical composition comprising a CNS-penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V) and an antidepressant or anti-anxiety agent together with at least one pharmaceutically acceptable carrier or excipient. It will be appreciated that the CNS-penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V) and and an antidepressant or anti-anxiety agent may be present as a combined preparation for simultaneous, separate or sequential use for the treatment or prevention of depression and/or anxiety. Such combined preparations may be, for example, in the form of a twin pack. In a further or alternative aspect of the present invention, there is therefore provided a product comprising a CNS-penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V) and and an antidepressant or anti-anxiety agent as a combined preparation for simultaneous, separate or sequential use in the treatment or prevention of depression and/or anxiety. In a preferred aspect, the present invention accordingly provides the use of a CNS-penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V) and an antidepressant agent selected from the group consisting of: norepinephrine reuptake inhibitors, selective serotonin reuptake inhibitors, monoamine oxidase inhibitors, reversible monoamine oxidase inhibitors, serotonin and noradrenaline reuptake inhibitors, corticotropin releasing factor (CRF) antagonists, α-adrenoreceptor antagonists and atypical antidepressants, for the manufacture of a medicament for the treatment or prevention of depression and/or anxiety. The present invention also provides a method for the treatment or prevention of depression and/or anxiety, which method comprises administration to a patient in need of such treatment an amount of a CNS-penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V) and an antidepressant agent selected from the group consisting of: norepinephrine reuptake inhibitors, selective serotonin reuptake inhibitors, monoamine oxidase inhibitors, reversible monoamine oxidase inhibitors, serotonin and noradrenaline reuptake inhibitors, corticotropin releasing factor (CRF) antagonists, α-adrenoreceptor antagonists and atypical antidepressants, such that together they give effective relief. In a further aspect of the present invention, there is provided a pharmaceutical composition comprising a CNS-penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V) and an antidepressant agent selected from the group consisting of: norepinephrine reuptake inhibitors, selective serotonin reuptake inhibitors, monoamine oxidase inhibitors, reversible monoamine oxidase inhibitors, serotonin and noradrenaline reuptake inhibitors, corticotropin releasing factor (CRF) antagonists, α-adrenoreceptor antagonists and atypical antidepressants, together with at least one pharmaceutically acceptable carrier or excipient. In a further or alternative aspect of the present invention, there is provided a product comprising a CNS-penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V) and an antidepressant agent selected from the group consisting of: norepinephrine reuptake inhibitors, selective serotonin reuptake inhibitors, monoamine oxidase inhibitors, reversible monoamine oxidase inhibitors, serotonin and noradrenaline reuptake inhibitors, corticotropin releasing factor (CRF) antagonists, α-adrenoreceptor antagonists and atypical antidepressants, as a combined preparation for simultaneous, separate or sequential use in the treatment or prevention of depression and/or anxiety. A particularly preferred class of antidepressant agent is the selective serotonin reuptake inhibitors, thus in a further preferred aspect, the present invention accordingly provides the use of a CNS-penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V) and a selective serotonin reuptake inhibitor for the manufacture of a medicament for the treatment or prevention of depression and/or anxiety. The present invention also provides a method for the treatment or prevention of depression and/or anxiety, which method comprises administration to a patient in need of such treatment an amount of a CNS-penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V) and an amount of a selective serotonin reuptake inhibitor, such that together they give effective relief. In a further aspect of the present invention, there is provided a pharmaceutical composition comprising a CNS-penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III). (IV) and (V) and a selective serotonin reuptake inhibitor, together with at least one pharmaceutically acceptable carrier or excipient. In a further or alternative aspect of the present invention, there is provided a product comprising a CNS-penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V) and a selective serotonin reuptake inhibitor as a combined preparation for simultaneous, separate or sequential use in the treatment or prevention of depression and/or anxiety. A particularly preferred class of anti-anxiety agent is the 5-HT I A agonists or antagonists, especially the 5-HTIA partial agonists, thus in a further preferred aspect, the present invention accordingly provides the use of a CNS-penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V) and a 5-HTIA receptor agonist or antagonist for the manufacture of a medicament for the treatment or prevention of depression and/or anxiety. The present invention also provides a method for the treatment or prevention of depression and/or anxiety, which method comprises administration to a patient in need of such treatment an amount of a CNS-penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V) and an amount of a 5-HTiA receptor agonist or antagonist, such that together they give effective relief. In a further aspect of the present invention, there is provided a pharmaceutical composition comprising a CNS-penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V) and a 5-HTIA receptor agonist or antagonist, together with at least one pharmaceutically acceptable carrier or excipient. In a further or alternative aspect of the present invention, there is provided a product comprising a CNS-penetrant NK-1 receptor antagonist selected from the compounds of formulae (I), (II), (III), (IV) and (V) and a 5-HT I A receptor agonist or antagonist as a combined preparation for simultaneous, separate or sequential use in the treatment or prevention of depression and/or anxiety. As stated above, the CNS-penetrant NK-1 receptor antagonist and the antidepressant or anti-anxiety agent may be formulated in a single pharmaceutical composition or alternatively in individual pharmaceutical compositions for simultaneous, separate or sequential use in accordance with the present invention. It will be appreciated that it may be desirable to combine the CNS- penetrant NK-1 receptor antagonist with more than one antidepressant and or anti-antiety agent. Thus "triple combination" or "multiple combination" therapy is envisaged within the scope of the present invention, for example, use of a CNS-penetrant NK-1 receptor antagonist of formulae (I), (II), (III), (IV) or (V) in combination with a selective serotonin reuptake inhibitor, such as fluoxetine, and a compound with 5-HTIA antagonist activity, such as pindolol. Preferably the compositions according to the present invention are in unit dosage forms such as tablets, pills, capsules, wafers and the like. Additionally, the active ingredients may be presented as granules or powders for extemporaneous formulation as volume defined solutions or suspensions. Alternatively, the active ingredients may be presented in ready-prepared volume defined solutions or suspensions. Preferred forms are tablets and capsules. For preparing solid compositions such as tablets, the principal active ingredient is mixed with a pharmaceutical carrier, e.g. conventional tableting ingredients such as corn starch, lactose, sucrose, sorbitol, talc, stearic acid, magnesium stearate, dicalcium phosphate or gums, and other pharmaceutical diluents, e.g. water, to form a solid preformulation composition containing a homogeneous mixture of a compound of the present invention, or a non-toxic pharmaceutically acceptable salt thereof. When referring to these preformulation compositions as homogeneous, it is meant that the active ingredient is dispersed evenly throughout the composition so that the composition may be readily subdivided into equally effective unit dosage forms such as tablets, pills and capsules. This solid preformulation composition is then subdivided into unit dosage forms of the type described above containing from 0.1 to about 500 mg of the active ingredient of the present invention. The tablets or pills of the novel composition can be coated or otherwise compounded to provide a dosage form affording the advantage of prolonged action. For example, the tablet or pill can comprise an inner dosage and an outer dosage component, the latter being in the form of an envelope over the former. The two components can be separated by an enteric layer which serves to resist disintegration in the stomach and permits the inner component to pass intact into the duodenum or to be delayed in release. A variety of materials can be used for such enteric layers or coatings, such materials including a number »f»polymeric acids and mixtures of polymeric acids with such materials " as shellac, cetyl alcohol and cellulose acetate. The liquid forms in which the novel compositions of the present invention may be incorporated for administration orally include aqueous solutions, suitably flavoured syrups, aqueous or oil suspensions, and flavoured emulsions with edible oils such as cottonseed oil, sesame oil, coconut oil, peanut oil or soybean oil, as well as elixirs and similar pharmaceutical vehicles. Suitable dispersing or suspending agents for aqueous suspensions include synthetic and natural gums such as tragacanth, acacia, alginate, dextran, sodium carboxy methylcellulose, methylcellulose, polyvinyl-pyrrolidone or gelatin. Compositions of the present invention may also be administered via the buccal cavity using conventional technology, for example, absorption wafers. Compositions in the form of tablets, pills, capsules or wafers for oral administration are particularly preferred. The present invention further provides a process for the preparation of a pharmaceutical composition comprising a CNS-penetrant NK-1 receptor antagonist and an antidepressant or anti-anxiety agent, which process comprises bringing a CNS-penetrant NK-1 receptor antagonist and an antidepressant or anti-anxiety agent, into association with a pharmaceutically acceptable carrier or excipient. When administered in combination, either as a single or as separate pharmaceutical composition(s), the CNS-penetrant NK-1 receptor antagonist and an antidepressant or anti-anxiety agent, are presented in a ratio which is consistent with the manifestation of the desired effect. In particular, the ratio by weight of the CNS-penetrant NK-1 receptor antagonist and the antidepressant or anti-anxiety agent will suitably be between 0.001 to 1 and 1000 to 1, and especially between 0.01 to 1 and 100 to 1. A suitable dosage level for the CNS-penetrant NK-1 receptor antagonist about 0.05 to 1500mg per day, preferably about 0.25 to 1500mg per day, and especially about 0.25 to 500mg per day. The compounds may be administered on a regimen of up to 6 times per day, preferably 1 to 4 times per day, especially 2 times per day and most especially once daily. A suitable dosage level for the antidepressant agent is about 0.5 to 1500mg per day, preferably about 2.5 to lOOOmg per day, and especially about 2.5 to 500mg per day. The compounds may be administered on a regimen of up to 6 times per day, preferably 1 to 4 times per day, especially 2 times per day and most especially once daily. A suitable dosage level for the anti-anxiety agent is about 0.5 to 1500mg per day, preferably about 2.5 to lOOOmg per day, and especially about 2.5 to 500mg per day. The compounds may be administered on a regimen of up to 6 times per day, preferably 1 to 4 times per day, especially 2 times per day and most especially once daily. It will be appreciated that the amount of the CNS-penetrant NK-1 receptor antagonist and the antidepressant or anti-anxiety agent required for use in the treatment or prevention of depression and/or anxiety will vary not only with the particular compounds or compositions selected but also with the route of administration, the nature of the condition being treated, and the age and condition of the patient, and will ultimately be at the discretion of the patient's physician or pharmacist. As used herein the term "patient" includes animals of economic importance such as bovine, ovine, and porcine animals, especially those that produce meat, as well as domestic animals (e.g. cats and dogs), sports animals (e.g. horses), zoo animals, and humans, the latter being preferred. The compounds of formulae (I), (II), (III), (IV) and (V) may be prepared by the methods described in EP-A-0 577 394 (or WO 95/16679), WO 95/18124, WO 95/23798, WO 96/05181 and WO 96/07649, respectively. As used herein, the term "CNS-penetrant" refers to NK- 1 receptor antagonists which are able to inhibit NK-1 receptor antagonist-induced foot-tapping in the gerbil as hereinafter defined. Essentially, hind foot-tapping in the gerbil induced by infusion of the NK-1 receptor agonist, GR73632 (d Ala[L-Pro 9 ,Me-Leu 10 ] -substance P- (7-11)), under anaesthesia, directly into the central ventricles is inhibited when a CNS-penetrant NK-1 receptor antagonist is administered intravenously immediately prior to GR73632 challenge, wherein hind foot- tapping over a period of five minutes following recovery from the anaesthesia is inhibited with an ID5o<3mg/kg, and preferably with an IDso≤lmg/kg. In an alternative method, the NK- 1 receptor antagonist is administered orally, 1 hour prior to GR73632 challenge, wherein the foot- tapping over a period of five minutes following recovery from anaesthesia is inhibited with an ID5o<30mg/kg, and preferably with an IDso≤lOmg/kg. CNS-penetrant NK-1 receptor antagonists of use in the present ivnention are also effective in the attenuation of separation-induced vocalisations by guinea-pig pups as hereinafter defined. Essentially, a vocalisation response in guinea-pig pups is induced by isolation from their mothers and littermates, which response is attenuated when a CNS-penetrant NK-1 receptor antagonist is administered subcutaneously 30 minutes prior to isolation, wherein vocalisations during the first 15 minutes of isolation are attenuated with an ID5o≤20mg/kg, preferably with an IDso≤lOmg/kg, and especially with an IDso≤δmg/kg. 5 In an alternative method, the NK-1 receptor antagonist is administered orally, 4 hours prior to isolation, wherein vocalisations during the first 15 minutes of isolation are attenuated with an ID5o≤20mg/kg, preferably with an IDso≤lOmg/kg, and especially with an IDso≤δmg/kg. 10 Whilst it is recognised in many of the aforementioned patent specifications that NK-1 receptor antagonists may be used to treat depression and/or anxiety, there remains a need for simple and reliable methods for the identification of compounds with NK-1 receptor antagonist activity which would be effective in the treatment of depression lδ and/or anxiety. The present invention accordingly provides a preclinical screen for antidepressant and/or anxiolytic activity of CNS-penetrant NK-1 receptor antagonists, which comprises: a) to a guinea-pig pup, administration of a NK- 1 receptor 20 antagonist or vehicle by intravenous, subcutaneous, intraperitoneal or oral routes; bl) 30-60 minutes after intravenous, subcutaneous or intraperitoneal administration, socially isolating the treated guinea-pig pups by removal from their mother and littermates; or 2δ b2) up to 4 hours after oral administration, socially isolating the treated guinea-pig pups by removal from their mother and littermates; c) recording the number or duration of vocalisations (isolation calls) during a specified period and comparing the effects on guinea-pig pups treated with NK-1 receptor antagonists against their own baseline or 30 against guinea-pig pups that receive no test compound or vehicle. Preferably the NK-1 receptor antagonist is administered by subcutaneous injection or orally by gavage. An advantage of the present invention is that the guinea-pig is a mammal with human-like NK-1 receptor pharmacology, δ The guinea-pig preclinical screen described herein has been shown to be sensitive not only to the anxiolytic and antidepressant effects of NK-1 receptor antagonists, but also to the effects of established anxiolytic and antidepressant drugs. Thus, for example, buspirone, diazepam, fluoxetine, and imipramine were all active in this assay (IDsc^O.δmg/kg 10 s.c, 0.7mg/kg s.c, 2.7mg/kg i.p. and δ.4mg/kg s.c, respectively). According to a futher aspect of the present invention, there is provided a preclinical screen for antidepressant and/or anxiolytic activity of CNS-penetrant NK-1 receptor antagonists, which comprises: a) to a gerbil, administration of a NK-1 receptor antagonist or lδ vehicle by intravenous, subcutaneous, intraperitoneal or oral routes; b) administration by injection under anaesthetic of NK-1 receptor agonists or anxiogenic agents, administered centrally or systemically; or subjecting the gerbil to stressors such as single housing or foot shock; 20 c) recording the duration of repetitive hindfoot tapping and comparing the effects on gerbils treated with NK-1 receptor antagonists against gerbils that receive no test compound or vehicle. Preferably the NK-1 receptor antagonist is administered by intravenous injection or orally by gavage. 2δ Suitable NK-1 receptor agonists which elicit repetitive hindfoot tapping include GR73632 (d-Ala[L-Pro 9 , Me- eu i °]substance P-(7-ll)), [Sar 9 , Met(O2) u ] substance P and substance P. Suitable anxiogenic agents include pentagastrin and adrenaline. The NK-1 receptor antagonist may be administered intravenously 30 about δ minutes before challenge with the NK-1 receptor agonist or anxiogenic agent or before the aversive stimulation, in order to measure the acute effect of the NK-1 receptor antagonist. If oral administration is chosen, it may be preferable to administer the NK-1 receptor antagonist at least one hour prior to central injection of the NK-1 receptor agonist or anxiogenic agent, or the aversive stimulus. In order to measure the δ central duration of action of a NK-1 receptor antagonist, the test compound is conveniently administered approximately 24 hours prior to central injection of the NK-1 receptor agonist or anxiogenic agent, or the aversive stimulus. Whilst there are many different genera of gerbil, the preferred 10 genui j»s the Mongolian gerbil (Meriones unguiculatus). An advantage of the present invention is that the gerbil is a mammal with human-like NK-1 receptor pharmacology. The preclinical screens described herein have been shown to be sensitive not only to the anxiolytic and antidepressant effects of NK-1 lδ receptor antagonists, but also to the effects of an established antidepressant drug, imipramine (IDso=3.8mg/kg s.c. following foot-tapping induced by substance P) and the anxiolytic drug, buspirone (ID 5 o=3.4mg/kg s.c). The identification of CNS-penetrant NKi receptor antagonists of use 20 as anxiolytic or antidepressant agents is carried out as follows: (i) Determine affinity for human NKi receptor in radioligand binding studies (Assay 1); select compounds with IC50 < lOnM, preferably IC50 < 2nM, especially IC50 < InM. (ii) Determine activity of compounds for their ability to inhibit 2δ distress vocalisations in guinea-pig pups (Assay 2)). Select compounds with ID50 ≤ 20mg/kg, and preferably ID50 ≤ lOmg/kg, and especially ID50 < δmg/kg. According to an alternative aspect of the present invention, the identification of NKi receptor antagonists of use as anxiolytic or 30 antidepressant agents is carried out as follows: (i) Determine affinity for human NKi receptor in radioligand binding studies (Assay 1); select compounds with IC50 ≤ lOnM, preferably IC 50 < 2nM, especially IC50 < InM. (ii) Determine ability of compounds to penetrate CNS by their δ ability to inhibit foot tapping in gerbils induced by central injection of an NKi agonist (Assay 3); select compounds that inhibit foot tapping with IDδc ≤ 3mg/kg i.v., and preferably ID50 < lmg/kg i.v. when administered immediately prior to central NKi agonist challenge, or ID S Q < 30mg/kg p.o., and preferably ID50 ≤ lOmg/kg p.o. 1 hour prior to challenge. 10 (iii) Determine central duration of action of compounds in gerbil foot tapping assay following intravenous administration 24 hours prior to central NKi agonist challenge; select compounds showing < 2δ-fold loss of potency compared with IDso determined in step (ii) above with the proviso that ID50 ≤ lOmg/kg i.v., and preferably < δmg/kg i.v. after 24 hour lδ pre-treatment. Yet further preferred compounds of use as anxiolytic or antidepressant agents may be selected, according to either of the "selection cascades" described above, from those compounds which satisfy the NK-1 receptor binding criteria of step (i) which, in addition, have < δ-fold shift in 20 affinity when incubated in the presence of human serum albumin (HSA) to show non-specific protein binding. It will be appreciated that, if desired, the above "selection cascades" may be combined. Thus, a further method for the identification of NK-1 receptor antagonists of use as anxiolytic or antidepressant agents involves 2δ the use of Assay 1, Assay 2 and Assay 3, incorporating the selection criteria defined herein. Particularly active CNS-penetrant NK-1 receptor antagonists include: 2-(S)-(3,δ-bis(trifluoromethyl)benzyloxy)-3(S)-(4-fluorophenyl)-4-(3-(5-oxo- 30 lH,4H-l,2,4-triazolo)methyl)morpholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(3-(δ-oxo-lH,4H- 1, 2, 4-triazolo)methyl)-3-(S)-phenyl-morp holine; 2-(S)-(3,δ-bis(trifluoromethyl)benzyloxy)-4-(3-(δ-oxo-lH,4H-l,2,4- triazolo)methyl) - 3- (S) -p he nyl-morp holine ; δ 2-(R)-(l-(R)-(3,δ-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 4-(3-(δ-oxo-lH,4H-l,2,4-triazolo)methyl)morpholine; 2-(R)-(l-(R)-(3,δ-bis(trifluoromethyl)phenyl)ethoxy)-4-(δ-(N,N- dimethylamino)methyl-l,2,3-triazol-4-yl)methyl-3-(S)-phenylmorpholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(5-(N,N- 10 dimethylamino)methyl-l,2,3-triazol-4-yl)methyl-3-(S)-(4- fluorop he nyl)morp holine; 2-(S)-(l-(R)-(3,δ-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 4-(3-(l-monophosphoryl-δ-oxo-4H-l,2,4-triazolo)methyl)morpholine; 2-(R)-(l-(R)-(3,δ-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-N,N- lδ dimethylaminobut-2-yn-yl)-3-(S)-(4-fluorophenyl)morpholine; or a pharmaceutically acceptable salt thereof. According to a further aspect of the present invention, there is provided the use of a CNS-penetrant NK-1 receptor antagonist identified according to either of the preclinical screens defined herein for the 20 manufacture of a medicament for the treatment or prevention of depression and/or anxiety as previously defined. Similarly, there is also provided a method for the treatment or prevention of depression and/or anxiety as previously defined, which method comprises administration to a patient in need of such treatment 2δ an effective amount of a CNS-penetrant NK-1 receptor antagonist identified according to either of the preclinical screens defined herein. Particularly preferred CNS-penetrant NK-1 receptor antagonists of the formulae (I), (II), (III), (IV) and (V) for use in the present invention are compounds which are potent NK-1 receptor antagonists, i.e. compounds 30 with an NK-1 receptor affinity (IC50) of less than lOOnM. Preferably, the NK-1 receptor antagonist has ICso < lOnM, in particular IC50 < 2nM, and most especially IC50 ≤ InM. NK-1 receptor binding assays are well known in the art. The following assay is one such protocol based upon the displacement of 5 i25 I-Tyr 8 -substance P binding to cloned human NK-1 receptors in vitro: ASSAY 1: NK-1 Receptor binding Assay NK-1 receptor binding assays are performed in intact Chinese hamster ovary (CHO) cells expressing the human NK-1 receptor using a 10 .. modification of the assay conditions described by Cascieri et al, J. Pharmacol. Exp. Ther., 1992, 42, 4δ8. Typically, the receptor is expressed at a level of 3xl0 5 receptors per cell. Cells are grown in monolayer culture, detached from the plate with enzyme-free dissociation solution (Speciality Media Inc.), and washed prior to use in the assay. i25 .ι r 8. lδ substance P (O.lnM, 2000Ci/mmol; New England Nuclear) is incubated in the presence or absence of test compounds (dissolved in δμl dimethylsulphoxide, DMSO) with δxlO 4 CHO cells. Ligand binding is performed in 0.2δml of δOmM Tris-HCl, pH7.δ, containing δmM MnCl 2 , 150mM NaCl, 0.02% bovine serum albumin (Sigma), 50μg/ml chymostatin 20 (Peninsula), O.lnM phenylmethylsulphonyl fluoride, 2μg/ml pepstatin, 2μg/ml leupeptin and 2.8μg/ml furoyl saccharine. The incubation proceeds at room temperature until equilibrium is achieved (>40 minutes) and the receptor-ligand complex is harvested by filtration over GF/C filters pre- soaked in 0.1% polyethylenimine using a Tomtek 96-well harvester. Non- 26 specific binding is determined using excess substance P (lμM) and represents <10% of total binding. Pharmacological assays for the study of antidepressant or antianxiety activity are well known in the art. Many are based upon the 30 ability of antidepressants to support animal behaviour in stressful situations that ordinarily lead to diminished behavioural responsiveness ("learned helplessness"), such as repeated noxious shocks, forced swimming, or separation from other animals. For example, the following assay, which involves the inhibition of separation-induced vocalisations in guinea-pig pups, may be used to evaluate the methods of the present δ invention in the treatment or prevention of depression and/or anxiety. ASSAY 2: Separation-Induced Vocalisation Male and female guinea-pigs pups are housed in family groups with their mothers and littermates throughout the study. Experiments are 10 commenced after weaning when the pups are at least 2 weeks old. Before entering an experiment, the pups may be screened to ensure that a vigorous vocalisation response is reproducibly elicited following maternal separation. The pups are placed individually in an observation cage (approximately δδcm x 39cm x 19cm) in a room physically isolated from lδ the home cage for approximately lδ minutes and the duration and/or number of vocalisation during this baseline period is recorded. Those animals which vocalise for longer than δ minutes may be employed for drug challenge studies (approximately δ0% of available pups may fail to reach this criterion). On test days each pup receives an oral dose or an s.c. 20 or i.p. injection of test compound or vehicle and is then immediately returned to the home cage with its mother and siblings, typically for at least 30 to 60 minutes (or for up to 4 hours following an oral dose, dependent upon the oral pharmacokinetics of the test compound) before social isolation for lδ minutes as described above. The duration and/or 2δ number of vocalisation on drug treatment days may be expressed as a percentage of the pre-treatment baseline value for each animal or compared with values obtained in vehicle -treated animals. The same subjects may be retested once weekly for up to 6 weeks. Between 6 and 8 animals typically receive each test compound at each dose tested. 30 ASSAY 3: Gerbil Foot-Tapping (CNS Penetration) Assay CNS-penetrant NK-1 receptor antagonists for use in the present invention can be identified by their ability to inhibit foot tapping in gerbils induced by anxiogenic agents (such as pentagastrin) or central infusion of NK-1 receptor agonists such as GR73632, or caused by aversive stimulation such as foot shock or single housing, based on the method of Rupniak & Williams, Eur. J. Pharmacol, 1994, 265, 179. Male or female Mongolian gerbils (3δ-70g) are anaesthetised by inhalation of an isoflurane/oxygen mixture to permit exposure of the jugular vein in order to permit administration of test compounds or vehicle in an injection volume of approximately 5ml/kg i.v. Alternatively, test compounds may be administered orally or by subcutaneous or intraperitoneal routes. A skin incision is then made in the midline of the scalp to expose the skull. An anxiogenic agent (e.g. pentagastrin) or a selective NK-1 receptor agonist (e.g. GR73632 (d Ala[L-Pro 9 ,Me-Leu i °]- substance P-(7-ll)) is infused directly into the cerebral ventricles (e.g. 3pmol in δμl i.e. v., depending on test substance) by vertical insertion of a cuffed 27 gauge needle to a depth of 4.5mm below bregma. The scalp incision is closed and the animal allowed to recover from anaesthesia in a clear perspex observation box (approximately 25cm x 20cm x 20cm). The duration and/or intensity of hind foot tapping is then recorded continuously for approximately 5 minutes. Alternatively, the ability of test compounds to inhibit foot tapping evoked by aversive stimulation, such as foot shock or single housing, may be studied using a similar method of quantification. It will be appreciated that CNS-penetration as defined by this assay and as used herein is a property of the NK-1 receptor antagonist and is not conferred by co-administration or co-formulation of the NK-1 receptor antagonist with a carrier or excipient designed to transiently open the blood-brain barrier. One example of a NK-1 receptor antagonist active in the preclinical screens of the present invention is the compound 2-(R)-(l-(R)-(3,δ- bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)-4-(3-(δ-oxo- lH,4H-l,2,4-triazolo)methyl)morpholine, the preparation of which is described in International Patent Specification No. WO 96/16679. In the aforementioned assays, this compound has the following activity: human NK-1 receptor binding: ICso^O.lnM guinea-pig vocalisation ID5o=0.73mg/kg p.o. (4 hrs. pretreatment) gerbil foot-tapping (δ mins.): ID5o=0.36mg/kg i.v. gerbil foot-tapping (24 hrs.): IDso^O.SSmg/k i.v. Another example of a NK-1 receptor antagonist active in the preclinical screens of the present invention is the compound 2-(R)-(l-(R)- (3,δ-bis(trifluoromethyl)phenyl)ethoxy)-4-(δ-(N,N-dimethylamino)methyl- l,2,3-triazol-4-yl)methyl-3-(S)-phenylmorpholine, the preparation of which is described in International Patent Specification No. WO 95/18124. In the aforementioned assays, this compound has the following activity: human NK-1 receptor binding: IC 5 o=0.25nM guinea-pig vocalisation: IDδo-O.δmg/kg s.c. gerbil foot-tapping (5 mins.): ID 50 =0.12mg/k i.v. gerbil foot-tapping (24 hrs.): ID 5 o=0.17mg/kg i.v. Combinations of a CNS-penetrant NK-1 receptor antagonist with the anti-anxiety and antidepressant agents, buspirone and fluoxetine, have been tested in the guinea-pig vocalisation assay (Assay 3): Test Compound A is 2-(R)-(l-(R)-(3,δ-bis(trifluoromethyl)phenyl) ethoxy)-4-(5-(dimethylamino)methyl-l,2,3-triazol-4-yl)methyl-3-(S)- p he nylmorp holine . Test Compound B is the less active enantiomer of Test Compound A - i.e. 2-(S)-(l-(R)-(3,δ-bis(trifluoromethyl)phenyl)ethoxy)-4-(5- (dimethylamino)methyl-l,2,3-triazol-4-yl)methyl-3-(R)-phenylmorphohne. Test Compounds A and B and buspirone were dissolved in 0.9 % saline and administered s.c. in the flank. Due to limitations of solubility, fluoxetine was suspended in O.δ % methocel and given i.p. The injection volume was 1 ml/kg. Results Guinea-pig pups isolated from their mothers and littermates emitted a vigorous vocalisation response during the first 15 minutes of separation (total duration approximately 8 minutes during this period). Administration of the highly CNS penetrant NK-1 receptor antagonist Test Compound A (0.25mg/kg s.c), buspirone (0.2δmg/kg s.c), or fluoxetine (2mg/kg i.p.) alone 30 minutes previously attenuated separation-induced vocalisations by approximately 25% compared with the baseline vocalisation response determined using the same animals on the previous day. Combined administration of Test Compound A (0.25mg/kg s.c.) with either buspirone (0.2δmg/kg s.c.) or fluoxetine (2mg/kg i.p.) virtually abolished separation-induced vocalisations (Figures 1 & 2). The NK-1 receptor specificity of this effect was confirmed by the failure of the less active enantiomer, Test Compound B (0.25mg/kg s.c.) to attenuate separation-induced vocalisations when administered alone, or to potentiate the inhibitory effect of buspirone (0.2δmg/kg s.c; Figure 1). The above results provide evidence for a synergistic interaction between a centrally acting NK-1 receptor antagonist (Test Compound A) with the anti-anxiety and antidepressant drugs buspirone and fluoxetine in a distress vocalisation assay using guinea-pigs. This appears to reflect a specific NK-1 receptor mediated interaction, since co- administration of the less active enantiomer, Test Compound B, at the same dose failed to potentiate the ability of buspirone to inhibit vocalisations. The findings provide the first experimental evidence that centrally acting NK-1 receptor antagonists may augment the therapeutic response to clinically used anti-anxiety and antidepressant drugs, including agents acting as agonists or antagonists at the 6-HTIA receptor (such as buspirone), and selective serotonin reuptake inhibitors (such as fluoxetine). It will be appreciated from the foregoing description that an advantage of the combinations of the present invention is the oral bioavailability of the NK-1 receptor antagonists of use in such combinations. Pharmacokinetic analysis to determine the oral bioavailability of the NK-1 receptor antagonists may be effected simply by measuring the ability of the NK-1 receptor antagonist to inhibit NK-1 receptor agonist-induced foot-tapping in the gerbil following oral administration of the NK-1 receptor antagonist. Compounds with an ID50≤30mg/kg p.o., and preferably IDso≤lOmg/kg p.o., following administration 1 hour prior to central NK-1 receptor agonist challenge are considered to be orally active according to the present invention. An alternative pharmacokinetic analysis takes advantage of the ability of CNS-penetrant NK-1 receptor antagonists to atenuate cisp latin- induced emesis. Orally active, CNS-penetrant NK-1 receptor antagonists demonstrate this activity in the following assay: ASSAY 4: Ferret Emesis Individually housed male ferrets (1.0 -2.5 kg) are dosed orally by gavage with test compound. Ten minutes later they are fed with approximately lOOg of tinned cat food. At 60 minutes following oral dosing, cisplatin (lOmg/kg) is given i.v. via a jugular vein catheter inserted under a brief period of halothane anaesthesia. The catheter is then removed, the jugular vein ligated and the skin incision closed. The ferrets recover rapidly from the anaesthetic and are mobile within 10-20 minutes. The animals are observed continuously during recovery from the anaesthetic and for 4 hours following the cisplatin injection. The numbers of retches and vomits occurring during the 4 hours after cisplatin administration are recorded by trained observers. Oral bioavailability of the NK-1 receptor antagonist is determined by its ability to inhibit cisplatin -induced emesis in ferrets following oral administration (Assay 4). Compounds with an ID9o<3mg/kg p.o., and preferably IDθo≤lmg/kg p.o., are considered to be orally active according to the present invention. Thus, for example, the NK- 1 receptor antagonist 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)morpholine, mentioned above, has an ID90 in the ferret emesis assay (Assay 4) of <3mg/kg p.o. The following examples illustrate pharmaceutical compositions according to the invention. These formulations may be prepared with separate active ingredients or with a combination of active ingi'edients in one composition. In such combined preparations, the ratio of the CNS-penetrant NK- 1 receptor antagonist and the antidepressant or an ti- anxiety agent will depend upon the choice of active ingredients. EXAMPLE 1 Tablets containing 50-300mg of NK-1 antagonist and 5-10mg of buspirone Amoui it mg NK-1 antagonist 50.0 50.0 100.0 100.0 300.0 300.0 buspirone 5.0 10.0 5.0 10.0 δ.O 10.0 Microcrystalline cellulose 80.0 80.0 80.0 80.0 80.0 80.0 Modified food corn starch 80.0 80.0 80.0 80.0 80.0 80.0 Lactose 84.5 179.5 134.5 129.5 134.6 129.5 Magnesium Stearate 0.5 0.5 0.5 0.5 O.δ 0.5 EXAMPLE 2 Tablets containing 50-300mg of NK- 1 antagonist and 20mg of fluoxetine Amount mg NK-1 antagonist 50.0 100.0 300.0 fluoxetine 20.0 20.0 20.0 MicrocrystaUine cellulose 80.0 80.0 80.0 Modified food corn starch 80.0 80.0 80.0 Lactose 169.5 119.5 119.5 Magnesium Stearate 0.5 0.5 0.5 The active ingredients cellulose, lactose and a portion of the corn starch are mixed and granulated with 10% corn starch paste. The resulting granulation is sieved, dried and blended with the remainder of the corn starch and the magnesium stearate. The resulting granulation is then compressed into tablets containing 50mg, lOOmg and 300mg of the CNS-penetrant NK-1 receptor antagonist per tablet. CLAIMS: 1. Use of a NK-1 receptor antagonist and an antidepressant or anti-anxiety agent for the manufacture of a medicament for the treatment 5 or prevention of depression and/or anxiety, characterised in that said NK-1 receptor antagonist is CNS-penetrant as determined by its ability to inhibit NK- 1 receptor agonist-induced foot-tapping in the gerbil, and is effective in the attenuation of separation -induced vocalisations by guinea-pig pups, and wherein said medicament is adapted for oral 10 adminsitration. 2. Use as claimed in claim 1 wherein the NK-1 receptor antagonist inhibits NK-1 receptor agonist-induced foot-tapping in the gerbil with an IDso<3mg/kg i.v. when administered immediately prior to lδ central NK-1 receptor agonist challenge; or an ID5o≤30mg/kg p.o. when administered 1 hour prior to central NK-1 receptor agonist challenge. 3. Use as claimed in claim 2 wherein the NK-1 receptor antagonist additionally shows <2δ-fold loss of potency in its inhibition of 20 NK- 1 receptor agonist-induced foot-tapping in the gerbil following intravenous administration 24 hours prior to central NK-1 receptor agonist challenge, with the proviso that the IDso≤lOmg/kg i.v. after 24 hour pre-treatment. 25 4. Use as claimed in any one of claims 1 to 3 wherein the NK- 1 receptor antagonist attenuates separation-induced vocalisations by guinea-pig pups with an IDr>o<20mg/kg. 5. Use as claimed in any one of claims 1 to 4 wherein the NK- 1 30 receptor antagonist has an affinity for the human NK-1 receptor of ICso≤lOnM. 6. Use as claimed in any one of claims 1 to 5 wherein the NK-1 receptor antagonist is a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: R i is selected from the group consisting of: (1) Ci-calkyl, substituted with one or more of the substituents selected from: 10 (a) heterocycle, wherein the heterocycle is selected from the group consisting of: (A) benzimidazolyl, (B) imidazolyl, (C) isoxazolyl, lδ (D) isothiazolyl, (E) oxadiazolyl, (F) pyrazinyl, (G) pyrazolyl, (H) pyridyl, 20 (I) pyrrolyl, (J) tetrazolyl, (K) thiadiazolyl, (L) triazolyl, and (M) piperidinyl, 26 and wherein the heterocycle is unsubstituted or substituted with one or more substituent(s) selected from: (i) Ci-calkyl, unsubstituted or substituted with halo, -CF 3 , -OCH3, or phenyl, (ii) Ci-calkoxy, (in) oxo, (iv) thioxo, (v) cyano, (vii) phenyl, (viii) hydroxy, (ix) trifluoromethyl, (x) -(CH 2 )m-NR 9 R °, wherein m is 0, 1 or 2, and R 9 and R i ° are independently selected from: (I) hydrogen, (II) Ci-calkyl, (III) hydroxy Ci-calkyl, and (IV) phenyl, (xi) -NR 9 COR i °, wherein R 9 and R 10 are as defined above, and (xii) -CONR 9 R i °, wherein R 9 and R 10 are as defined above, R 2 and R 3 are independently selected from the group consisting of: (1) hydrogen; (2) Ci-calkyl (3) C2-ealkenyl, and (δ) phenyl; X is -O-; R is R 5 is phenyl, unsubstituted or substituted with halo; R G , R 7 and R 8 are independently selected from the group consisting of: (1) hydrogen, (2) Ci-calkyl, (3) halo, and (4) -CF 3 ; Y is -O-; and Z is hydrogen or Cι-4alkyl. 7. Use as claimed in any one of claims 1 to 5 wherein the NK-1 receptor antagonist is a compound of formula (Ila): 10 (Ha) or a pharmaceutically acceptable salt thereof, wherein: A i is fluorine or CF3; A 2 is fluorine or CF3; A 3 is fluorine or hydrogen; lδ R 6 is a 5-membered or 6-membered heterocyclic ring containing 2 or 3 nitrogen atoms optionally substituted by =O, =S or a Cι-4alkyl group, and optionally substituted by a group of the formula ZNR 7 R 8 where Z is Ci-ealkylene or C3-6cycloalkylene; R 7 is hydrogen, Cι-4alkyl, C3-7cycloalkyl or C3-7cycloalkylCι-4alkyl, or 20 C2-4alkyl substituted by Cι-4alkoxy or hydroxyl; R 8 is hydrogen, Cι-4alkyl, C3-7cycloalkyl or C3-7cycloalkylCι-4alkyl, or C 2 -4alkyl substituted by one or two substituents selected from Cι- 4 alkoxy, hydroxyl or a 4, 5 or 6 membered heteroaliphatic ring containing one or two heteroatoms selected from N, 0 and S; or R 7 , R 8 and the nitrogen atom to which they are attached form a heteroaliphatic ring of 4 to 7 ring atoms, optionally substituted by a hydroxy group, and optionally containing a double bond, which ring may optionally contain an oxygen or sulphur ring atom, a group S(O) or S(O) 2 or a second nitrogen atom which will be part of a NH or NR C moiety where R c is Cι-4alkyl optionally substituted by hydroxy or Cι-4alkoxy; or R 7 , R 8 and the nitrogen atom to which they are attached form a non-aromatic azabicyclic ring system of 6 to 12 ring atoms; or Z, R 7 and the nitrogen atom to which they are attached form a heteroaliphatic ring of 4 to 7 ring atoms which may optionally contain an oxygen ring atom; X is an alkylene chain of 1 to 4 carbon atoms optionally substituted by oxo; and Y is a Cι-4alkyl group optionally substituted by a hydroxyl group; with the proviso that if Y is Cι-4alkyl, R 6 is susbstituted at least by a group of formula ZNR 7 R 8 as defined above. 8. Use as claimed in any one of claims 1 to 5 wherein the NK-1 receptor antagonist is a compound of formula (III): or a pharmaceutically acceptable salt thereof, wherein: R 2 and R 3 are independently selected from the group consisting of: (1) hydrogen, δ (2) Ci-calkyl, (3) C 2 -calkenyl, and (4) phenyl; R 6 , R 7 and R 8 are independently selected from the group consisting of: (1) hydrogen, δ (2) Ci-calkyl, (3) fluoro, (4) chloro, (5) bromo, (6) iodo, and 0 (7) -CF 3 ; Ru, R i2 and R 13 are independently selected from the group consisting of: (1) fluoro, (2) chloro, (3) bromo, and δ (4) iodo; A is unsubstituted ι-ealkyl; B is selected from the group consisting of: X N-N N ~ \\ N-N ^ ^ N N 1 N X X p is 0 or 1; X is selected from: (a) -PO(OH)O " • M + , wherein M + is a pharmaceutically acceptable monovalent counterion, (b) -PO(O-) 2 • 2M + , (c) -PO(O " )2 ' D 2+ , wherein D 2+ is a pharmaceutically acceptable divalent counterion, (d) -CH(R )-PO(OH)O " • M + , wherein R 4 is hydrogen or Cι- 3 alkyl, (e) -CH(R )-PO(O-) 2 • 2M + , (f) -CH(R )-PO(O-) 2 • D 2+ , (i) -CO-CH2CH2-CO2- • M + , (j) -CH(CH3)-O-CO-R 5 , wherein R 5 is selected from the group consisting of: (i) , NH 3 IVI " 0 ' H 2 IVI " (ϋ) .N 0 ' OH (iϋ) 0 C0 2 " M Y is -O-; and Z is hydrogen or Ci-calkyl. 9. Use as claimed in any one of claims 1 to 5 wherein the NK-1 receptor antagonist is a compound of formula (IVa): or a pharmaceutically acceptable salt thereof, wherein: A i is fluorine or CF3; A 2 is fluorine or CF3; A 3 is fluorine or hydrogen; X is a group of the formula NR 6 R 7 or a C- or N-linked imidazolyl ring; Y is hydrogen or Cι-4alkyl optionally substituted by a hydroxy group; R 6 is hydrogen, Ci-Galkyl, C3-7cycloalkyl, C3-7cycloalkylCι-4alkyl, phenyl, or C 2 -4alkyl substituted by Cι-4alkoxy or hydroxy; R 7 is hydrogen, Ci-calkyl, C3-7cycloalkyl, C3-7cycloalkylCι- 4 alkyl, phenyl, or C2-4alkyl substituted by one or two substituents selected from Cι-4alkoxy, hydroxy or a 4, 5 or 6 membered heteroaliphatic ring containing one or two heteroatoms selected from N, O and S; or R 6 and R 7 , together with the nitrogen atom to which they are attached, form a saturated or partially saturated heterocyclic ring of 4 to 7 ring atoms, which ring may optionally contain in the ring one oxygen or sulphur atom or a group selected from NR 8 , S(O) or S(O) 2 and which ring may be optionally substituted by one or two groups selected from hydroxyCι-4alkyl, Cι-4alkoxyCι-4alkyl, oxo, COR a or C0 2 R a where R a is hydrogen or Ci-4alkyl; or R 6 and R 7 together with the nitrogen atom to which they are attached, form a non-aromatic azabicyclic ring system of 6 to 12 ring atoms; and R 8 is hydrogen, Cι-4alkyl, hydroxy Cι-4alkyl or Cι-4alkoxyCι- 4 alkyl. 10. Use as claimed in any one of claims 1 to 5 wherein the NK-1 receptor antagonist is a compound of formula (Va): or a pharmaceutically acceptable salt thereof, wherein: A 1 is hydrogen, fluorine or CF3; A 2 is fluorine or CF3; A 3 is fluorine or hydrogen; R 6 is hydrogen, Ci-calkyl, C3-7cycloalkyl, C3-7cycloalkylC 1 -4alkyl, phenyl, or C2-4alkyl substituted by Cι- 4 alkoxy or hydroxy; R 7 is hydrogen, Ci-calkyl, C3-7cycloalkyl, C3-7cycloalkylCι-4alkyl, phenyl, C2-4alkyl substituted by Cι-4alkoxy or hydroxy, or the group C(=NR c )NR a R , where R a and R b are each independently hydrogen or Cι- 4 alkyl and R c is hydrogen, Ci-calkyl, CN or COR a ; or R 6 and R 7 , together with the nitrogen atom to which they are attached, form a saturated heterocyclic ring of 4 to 7 ring atoms which may optionally contain in the ring one oxygen or sulphur atom or a group selected from NR 8 , S(O) or S(O) 2 and which ring may be optionally substituted by one or two groups selected from phenyl, benzyl, hydroxyCι-4alkyl, Cι-4alkoxyCi-4alkyl, hydroxy, oxo, COR a or CU2R a where R a is as previously defined; or R 6 and R 7 , together with the nitrogen atom to which they are δ attached, form a piperidino ring substituted by a spiro-fused indene or indoline group, each of which may be unsubstituted or substituted on any available carbon atom by a group selected from Ci-calkyl, Ci-calkoxy, hydroxy, halogen, cyano, trifluoromethyl, SO2Ci-calkyl, NR a R b , NR a COR b or CONR a R b ; or, in the case of an indoline group, on the nitrogen atom by 10 a group selected from Ci-ealkyl, C3-7cycloalkyl, C3-7cycloalkylCi-4alkyl, phenylCι- alkyl, CO 2 R a , CONR a R b , SOR a or SO 2 R a , where R a and R b are as previously defined; R 8 is hydrogen, Ci-4alkyl, hydroxy Ci-4alkyl or Cι-4alkoxyCι-4alkyl; X is selected from -CH2CH2-, -COCH2- or -CH2CO-; and lδ Y is hydrogen, or Ci-4alkyl optionally substituted by a hydroxyl group. 11. Use as claimed in any one or claims 1 to 10 wherein the antidepressant agent is selected from norepinephrine reuptake inhibitors, 20 selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), reversible inhibitors of monoamine oxidase (RIMAs), serotonin and noradrenaline reuptake inhibitors (SNRIs), corticotropin releasing factor (CRF) antagonists, α-adrenoreceptor antagonists, atypical antidepressants, and noradrenergic and specific serotonergic 2δ antidepressants (NaSSAs). 12. Use as claimed in any one of claims 1 to 10 wherein the anti-anxiety agent is selected from benzodiazepines, 5-HTIA agonists, antagonists or partial agonists, corticotropin releasing factor (CRF) 30 antagonists and ml muscarinic cholinergic receptor agonists. 13. An oral pharmaceutical composition comprising a NK-1 receptor antagonist and an antidepressant or anti-anxiety agent, together with at least one pharmaceutically acceptable carrier or excipient, characterised in that said NK-1 receptor antagonist is CNS-penetrant as determined by its ability to inhibit NK- 1 receptor agonist-induced foot- tapping in the gerbil, and is effective in the attenuation of separation- induced vocalisations by guinea-pig pups. 14. A product comprising a NK-1 receptor antagonist and an antidepressant or anti-anxiety agent as a combined preparation for simultaneous, separate or sequential use in the treatment or prevention of depression and or anxiety, characterised in that said NK- 1 receptor antagonist is CNS-penetrant as determined by its ability to inhibit NK- 1 receptor agonist-induced foot-tapping in the gerbil, and is effective in the attenuation of separation-induced vocalisations by guinea-pig pups. 15. A method for the treatment or prevention of depression and/or anxiety, which method comprises oral administration to a patient in need of such treatment an amount of a NK-1 receptor antagonist and an amount of an antidepressant or anti-anxiety agent, such that together they give effective relief, wherein said NK-1 receptor antagonist is CNS- penetrant as determined by its ability to inhibit NK-1 receptor agonist- induced foot-tapping in the gerbil, and is effective in the attenuation of separation-induced vocalisations by guinea-pig pups. 16. A method as claimed in claim 15 wherein the NK-1 receptor antagonist is selected from the compounds of any one of formulae (I), (Ha), (III), (IVa) and (Va) as defined in claims 6 to 10. 17. A method as claimed in claim 15 wherein the antidepressant agent is selected from the group consisting of: norepinephrine reuptake inhibitors, selective serotonin reuptake inhibitors, monoamine oxidase inhibitors, reversible monoamine oxidase inhibitors, serotonin and noradrenaline reuptake inhibitors, corticotropin releasing factor (CRF) antagonists, α-adrenoreceptor antagonists and atypical antidepressants. 18. A method as claimed in claim lδ wherein the anti-anxiety agent is selected from the group consisting of benzodiazepines, 5-HTiA agonists, antagonists or partial agonists, corticotropin releasing factor antagonists and ml muscarinic cholinergic receptor agonists. 19. A method for the identification of antidepressant and/or anxiolytic activity of CNS-penetrant NK-1 receptor antagonists, which comprises: a) to a guinea-pig pup, administration of a NK-1 receptor antagonist or vehicle by intravenous, subcutaneous, intraperitoneal or oral routes; bl) 30-60 minutes after intravenous, subcutaneous or intraperitoneal administration, socially isolating the treated guinea-pig pups by removal from their mother and littermates; or b2) up to 4 hours after oral administration, socially isolating the treated guinea-pig pups by removal from their mother and littermates; and c) recording the number or duration of vocalisations (isolation calls) during a specified period and comparing the effects on guinea-pig pups treated with NK-1 receptor antagonists against their own baseline or against guinea-pig pups that receive no test compound or vehicle. 20. A method for the identification of antidepressant and/or anxiolytic activity of CNS-penetrant NK-1 receptor antagonists, which comprises: a) to a gerbil, administration of a NK-1 receptor antagonist or vehicle by intravenous, subcutaneous, intraperitoneal or oral routes; b) administration by injection under anaesthetic of NK-1 receptor agonists or anxiogenic agents, administered centrally or δ systemically; or subjecting the gerbil to stressors such as single housing or foot shock; and c) recording the duration of repetitive hindfoot tapping and comparing the effects on gerbils treated with NK-1 receptor antagonists against gerbils that receive no test compound or vehicle. 10 21. A method as claimed in claim 19 or claim 20 wherein the NK-1 receptor antagonist is administered by intravenous injection or orally by gavage. lδ 22. A method for the identification of CNS-penetrant NK-1 receptor antagonists of use as anxiolytic or antidepressant agents which comprises: (i) Determine affinity for human NK-1 receptor in radioligand binding studies and select compounds with IC50 ≤ lOnM; and 20 (ii) Determine activity of compounds for their ability to inhibit distress vocalisations in guinea-pig pups and select compounds with IDso < 20mg/kg. 23. A method for the identification of NK-1 receptor antagonists 25 of use as anxiolytic or antidepressant agents which comprises: (i) Determine affinity for human NK-1 receptor in radioligand binding studies and select compounds with IC50 < lOnM; (ii) Determine ability of compounds to penetrate CNS by their ability to inhibit foot tapping in gerbils induced by central injection of an 30 NK-1 agonist and; select compounds that inhibit foot tapping with ID50 ≤ 3mg/kg i.v., when administered immediately prior to central NK-1

Claims: agonist challenge, or IDso < 30mg/kg p.o. when administered 1 hour prior to central NK- 1 agonist challenge; and (iii) Determine central duration of action of compounds in gerbil foot tapping assay following intravenous administration 24 hours prior to central NK-1 agonist challenge and select compounds showing < 2δ-fold loss of potency compared with IDso determined in step (ii) above with the proviso that IDso < lOmg/kg i.v. after 24 hour pre-treatment. 24. A method as claimed in claim 22 or claim 23 which comprises the identification of compounds which satisfy the NK-1 receptor binding criteria of step (i) and which, in addition, have < 5-fold shift in affinity when incubated in the presence of human serum albumin (HSA). 25. Use of a CNS-penetrant NK-1 receptor antagonist identified according to a method as claimed in any one of claims 19 to 24 for the manufacture of a medicament for the treatment or prevention of depression and/or anxiety. 26. A method for the treatment or prevention of depression and/or anxiety, which method comprises administration to a patient in need of such treatment an effective amount of a CNS-penetrant NK-1 receptor antagonist identified according to the method of claim 20 or claim 21.

Inventors: CARLSON EMMA JOANNE, RUPNIAK NADIA MELANIE, CARLSON, EMMA, JOANNE, RUPNIAK, NADIA, MELANIE
Applicants: CARLSON EMMA JOANNE, MERCK SHARP & DOHME, RUPNIAK NADIA MELANIE, CARLSON, EMMA, JOANNE, MERCK SHARP & DOHME LIMITED, RUPNIAK, NADIA, MELANIE
Application year: 1997
Main classification: A61K31
IPC codes: A61K31, A61K45, A61K49, A61K51, A61P25