NEW PYRIDYL ALKANE ACID AMIDES AS CYTOSTATICS AND IMMUNOSUPPRESSIVES

Abstract: The invention relates to new pyridyl alkane acid amides according to general formula (I) as well as methods for their production, medicaments containing these compounds as well as their medical use, especially in the treatment of tumors or for immunosuppression.

Description: NEW PYRIDYL ALKANE ACID AMIDES AS CYTOSTATICS AND IMMUNOSUPPRESSIVES The invention relates to new pyridine compounds, methods for their production, medicaments containing these compounds as well as their use, especially in the treatment of tumor conditions and/or as cytostatic agents or as immunosuppressive agents A strong need exists for the enrichment of cytostatic therapy to provide pharmaceuticals and/or medicaments which not only possess a strong activity, but also exert diminished side effects in comparison to many classical cancerostatic agents, whereby treatment of a broad as possible spectrum of tumors should be made accessible Furthermore, effective cytostatic agents for an efficient therapy should be made available Active ingredients of this type should also be exceptionally suitable in the mentioned indications for a combination therapy, be it in connection with other cytostatic agents or with radiation (for example X-rays, radioactive elements, such as cobalt, or linear accelerator, etc ), with operative procedures, heat treatment, etc In this connection, a strong need also exists to enrich tumor therapy with new compounds for overcoming or preventing resistances for example This object was successfully solved in a completely supπsing manner by making available the pyπdyl alkane acid amide derivatives defined below It was known that various pyridine compounds substituted in a specific manner have pharmacologically useful properties which he however in completely different indication areas Thus, ω-pyπdyl alkane and/or alkene amides with anti-allergic activity are described in EP 0 210 782 which are referred to as having a 5-lιpoxygenase-ιnhιbιtιng and anti- histamine action, wherein the amide components of these compounds contain a pipeπzine or homopipeπzme ring and the pyridine ring can be linked together in the 2-, 3- or 4-posιtιon JP 63,179,869 describes further pyπdyl amides, ω-pyπdyl alkane and alkene amides as anti-allergic effective substances containing a substituted pipeπdine ring in the amine component Such compounds with the same properties are mentioned in Chem Pharm Bull 37, 100-105 (1989) and in J Med Chem 1989, 583-593 Pyridyl ureas, pyridyl thioureas and pyridyl carbonamides, wherein the amide portion is bound over an aryl substituted alkyl chain with a piperidine ring or piprazine ring, are described for example in EP-A-0 428 434 or in EP-A-0 512 902 as antagonists of the neurokinin receptor and subtance P. Furthermore, pyridyl(alkyl)carbonamides, pyridyl(alkyl)sulfonamides and analogous ureas, wherein the amide portion is bound over an alkyl chain with a piperidine ring are disclosed in EP-A-0 479 601 as active ingredients with anti-arrhythmic properties. In WO 91/15 485, the production of pyridine-3,5-dicarboxylic acid esters and amides as well as their use for the treatment of tumor conditions is described. These compounds differ from the compounds according to the invention described below in very important structural features, for example by the dicarboxyl grouping on the pyridine ring or the absence of the hydrocarbon chain between the pyridine ring and the amide grouping. The compounds disclosed in WO 89/07 443 in the form of optically pure R(-)-Ni-guldipine and further analogous dihydropyridines with cytotoxic activity have larger structural differences. However, the compounds according to the invention unexpectedly possess a better activity and a wider spectrum of action despite the large structural differences. Structurally closely related compounds are represented by the antagonists of the histimine-Hrreceptor generally described in EP-A-0 343 307 which constitute substituted piperidine derivatives. However, no particular 3 -pyridyl substitutions derivatives are concretely described in this publication. In view of this art, the finding that the compounds according to the general formula (I) defined below have activities which make them particularly suitable in an excellent manner for the therapy of tumor illnesses was completely unexpected. Equally unexpected was the pharmacological finding that the compounds according to the invention also possess immunosuppressive properties besides cytostatic activity. Pharmacological test results as well as the concrete tumor indications and combination possibilities are detailed and illustrated in the last part of the description. Therefore, subject-matter of the invention relates to compounds of formula (I) (I) wherein Rl is hydrogen, halogen, cyano, tnfluoromethyl, hydroxy, benzyloxy, aminocarbonyl, carboxy, phenyl, phenoxy, phenylthio, pyndyloxy, pyridylthio, alkyl, especially Ci -Cg-alkyl, alkenyl, especially C3-C6-alke yl, alkinyl, especially C3-C6-alkιnyl, hydroxyalkyl, especially Cι-C6-hydroxyalkyl, alkoxy, especially Cj-Cό-alkoxy, alkenyloxy, especially C3-C5-alkenyloxy, alkinyloxy, especially C3-C6-alkιnyloxy, alkanoyloxy, especially Cj-C -alkanoyloxy, alkoxycarbonyloxy, especially C2-C7-alkoxycarbonyloxy, alkylthio, especially Cj-Cβ-alkylthio, alkenylthio, especially C3-Cg-alkenylthιo, alkinylthio, especially C3-C6-alkιnylthιo, cycloalkyl, especially C3-Cg-cycloalkyl, cycloalkyloxy, especially C3-Cg-cycloalkyloxy, cycloalkylthio, especially C3-Cg-cycloalkylthιo, alkoxycarbonyl, especially C2-C7-alkoxycarbonyl, alkyl aminocarbonyl, especially C2-C7-alkylamιnocarbonyl, dialkylaminocarbonyl, especially C3-Ci 3-dιalkylamιnocarbonyl, or NR 5 R 6 , wherein R 5 and R*> are selected independently of each other from hydrogen, alkyl, especially C]-C6-alkyl, alkenyl, especially C3-C6-alkenyl and alkinyl, especially C3-C6-alkin l, R^ is hydrogen, halogen, cyano, hydroxy, tnfluoromethyl, benzyloxy, alkyl, especially C]-C6-aιkyl, alkoxy, especially C] -C6-alkoxy or alkanoyloxy, especially Ci-C -alkanoyloxy, wherein R and R^, if they are adjacent, optionally form a bridge which is selected from -(CH 2 )4-, -(CH=CH) 2 - and -CH 2 O-CR 7 R 8 -O-, wherein R 7 and R 8 are, independently of each other, hydrogen or alkyl, especially Cj-Cg-alkyl, R3 is hydrogen, halogen, alkyl, especially Cι-C6-aik l, tnfluoromethyl or hydroxyalkyl, especially C ] -Cg-hdroxyalkyl and R is hydrogen, hydroxy, benzyloxy, alkyl, especially C] -C6-alkyl, alkenyl, especially C3-C6-alkenyl, alkinyl, especially C3-C6-alkinyl, cycloalkyl, especially C3-C6-cycloalkyl or alkoxy, especially C j -Cg-alkoxy, A is alkylene, especially Ci -Cg-alkylene, which is optionally substituted once to three-fold by alkyl, especially C]-C3-alkyl, hydroxy, alkoxy, especially C] -C3- alkoxy, fluorine or phenyl, or 1,2-cyclopropylene or alkylene with at least two C-atoms, especially C2-C f 5-alkylene in which a methylene unit can be isosteπcally replaced by O, S, NR^, CO, SO or SO 2 , wherein the lsostenc substitution, with the exception of =CO, cannot be adjacent to the amide group and wherein R9 is selected from hydrogen, alkyl, especially Cι -C6-alkyl, alkenyl, especially C3-Cg-alkenyl, alkinyl, especially C3-Cg-alkιnyI, acyl, especially Cj -Cg-acyl or alkylsulfonyl, especially C]-C6-alkylsulfonyl, D is selected from alkylene, especially C i -C ] rj-alkylene, optionally substituted once or twice by alkyl, especially Cj -Cg-alkyl, hydroxy, or alkoxy, especially C ] -Cg-alkoxy, alkenylene with at least two C-atoms, especially C2-Ci Q-alkenylene, which is optionally substituted once or twice by alkyl, especially Ci -C6-alkyl, hydroxy, or alkoxy, especially C \ -Cg-alkoxy, wherein the double bond can also be to ring E, alkinylene with at least three C-atoms, especially C3-C1 rj-alkinylene, optionally substituted once or twice by alkyl, especially Ci -Cg-alkyl, hydroxy or alkoxy, especially C 1 -C5-alkoxy, and alkylene, especially C1 -C1 rj-alkylene, alkenylene with at least two C-atoms, especially C2-C1 Q -alkenylene or alkinylene with at least three C-atoms, especially C3-C]Q-alkιnylene, whereby one to three methylene units are each lsostencally replaced by O, S, NR*", CO, SO or SO2 wherein RlO has the same meaning as R but is selected independently thereof, E is selected from (El) or ( (E2) wherein the heterocychc ring can also optionally have a double bond and n and p can be, independently of one another, 0, 1, 2 or 3, with the proviso that n + p < 4 and RU IS hydrogen, alkyl, especially Ci -Cg-alkyl, hydroxy, hydroxym ethyl, carboxy or alkoxycarbonyl with at least two C-atoms, especially C2-C7-alkoxycarbonyl and R*2 IS hydrogen, alkyl, especially Ci -C5-alkyl or or an oxo group adjacent to the nitrogen atom, wherein RU and R^ optionally together, form an alkylene bridge with 1, 2, 3, 4 or 5 C-atoms, especially a C1-C3 -alkylene bridge under formation of a bicychc ring system, G is selected from hydrogen, Gl, G2, G3, G4 and G5, wherein Gl represents the residue wherein r is an integer from 1 to 3 or 0 and Rl3 IS selected from hydrogen, alkyl, especially C j -Cg-alkyl, alkenyl with at least three C-atoms, especially C3-C6-alkenyl, alkinyl with at least three C-atoms, especially C3-Cg-alkιnyl, cycloalkyl with at least three C-atoms, especially C3- Cg-cycloalkyl, saturated, five to seven membered heterocycles, which can contain one or two hetero-atoms from the group N and/or S and/or O, benzyl or phenyl, monocyclic aromatic five or six-membered heterocycles, which can contain one to three hetero-atoms from the group N and/or S and/or O and are either bound directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated carbocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated heterocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from N and/or S and/or O and the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, Rl 4 has the same meaning as R^, but is selected independently thereof, R! 5 IS selected from hydrogen, hydroxy, methyl, benzyl, phenyl, monocyclic aromatic five- or six-membered heterocycles, which can contain one to three hetero-atoms selected from the group N and/or S and/or O and are either bound directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated carbocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated heterocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from N and/or S and/or O and the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, is the residue C (CH 2 ) r (CR 14 R 15 ) S R 13 O (G2a) or C (CH 2 ) r NR 13 R 15 O (G2b) wherein the substituents R^ and R^ can have the above meaning or the grouping NR 13 R 15 can also be a nitrogen heterocycle bound over the nitrogen atom, selected from saturated or unsaturated monocyclic, four- to eight-membered heterocycles, which, aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from the group N and/or S and/or O, or saturated or unsaturated bi- or tricychc, anellated or bridged heterocycles with 8 to 16 ring atoms, which, aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from the group N and/or S and/or O, G3 is the residue (G3) and G4 is the residue (G4) wherein Ai- Ϊ and Ar^ are selected independently from one another from phenyl, pyridyl or naphthyl and G5 is the residue COR 16 (G5) wherein Rl6 is selected from tnfluoromethyl, alkoxy, especially C] -Cg-alkoxy, alkenyloxy, especially C3-C6-alkenyloxy, or benzyloxy, wherein any aryl residues and/or aromatic ring systems in the substituents R l , R 2 , R 4 ; R 13 , R 14 , R 15 , R 16 , Ar 1 and Ar 2 and/or in the ring system -NR 13 R 15 can be substituted independently from each other by one to three of the same or different residues which are selected from halogen, cyano, alkyl, especially Cj -Cg-alkyl, tnfluoromethyl, cycloalkyl, especially C3-Cg-cycloalkyl, phenyl, benzyl, hydroxy, alkoxy, especially C]-Cg-alkoxy, alkoxy, substituted entirely or partially by fluorine, substituted alkoxy, especially C\-C -a\ oxy, benzyloxy, phenoxy, mercapto, alkylthio, especially Cj-Cg-alkylthio, carboxy, alkoxycarbonyl, especially C] -Cg- alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, monoalkylamino, especially mono- C j -Cg-alkylamino, dialkylamino, especially dι-(Cι -C f 5-alkyl)-amιno and methylenedioxy for two adjacent groups on the aromatic ring or ring system, wherein each of the residues alkyl, alkenyl, alkinyl, hydroxyalkyl, alkoxy, alkenyloxy, alkinyloxy, alkanoyloxy, alkoxycarbonyl, alkoxycarbonyloxy, alkylthio, alkenylthio, alkinylthio, alkylene, acyl, alkylsulfonyl, alkenylene, alkinylene, cycloalkyl, cyc- loalkyloxy, alkoxycarbonyl, alkylaminocarbonyl or dialkylammocarbonyl of the substituents R* to R* 4 can have 1 to 2 or 4, 6, 8, 10 or 12 C-atoms and/or 2 or 3 to 5, 7, 9, 1 1 or 13 and/or 15 C-atoms or 4, 5, 6, 7, 8, 9, 10, 1 1 , 12, 13, 14 or 15 C-atoms depending on the structure, as well as stereoisomers and/or mixtures thereof and pharmacologically acceptable acid addition salts A preferred embodiment according to the invention relates to compounds of formula (I) (I) wherein Rl is a hydrogen, halogen, cyano, Cj-Cg-alkyl, C3-C f 5-alkenyl, C3-C6-alkinyl, tnfluoromethyl, C3-Cg-cycloalkyl, Cj -Cg-hydroxyalkyl, hydroxy, CJ -C6- alkoxy, C3-C6- alkenyloxy, C3-C f 5-alkinyloxy, benzyloxy, C]-C7-alkanoyloxy, C2"C7-alkoxycarbonyloxy, Cj-C^-alkylthio, C3-C6-alkenylthio, C3-C6- alkinylthio, C3-Cg-cycloalkyloxy, C3-Cg-cycloalkylthio, C2-C7- alkoxycarbonyl, aminocarbonyl, C2-C7-alkylaminocarbonyl, C3-C13- dialkylaminocarbonyl, carboxy, phenyl, phenoxy, phenylthio, pyridyloxy, pyridylthio, or NR^R^, wherein R 5 and R* > are selected independently from each other from hydrogen, Cj -C6-alkyl, C3- Cg-alkenyl and C3-C6-alkinyl, R 2 is hydrogen, halogen, cyano, Cj-Cg-alkyl, tnfluoromethyl, hydroxy, Ci -Cg- alkoxy, benzyloxy or Ci -C7-alkanoyloxy, wherein R l and R 2 , in case they are adjacent, optionally form a bridge which is selected from the bridge members -(CH 2 )4- and -(CH=CH) 2 - and -CH 2 O-CR 7 R 8 -O-, wherein R 7 and R 8 are, independently from each other, hydrogen or C j -Cg-alkyl, R 3 is hydrogen, halogen, Cι -C6-alkyl, tnfluoromethyl or Ci-Cg-hydroxyalkyl and R 4 ΪS hydrogen, C}-C6-alkyl, C3-C6-alkenyl, C3-C6-alkιnyl, C3-C(5-cycloalkyl, hydroxy, Cι-C6-alkoxy or benzyloxy, A is C j -Cg-alkylene, which is optionally substituted once to three-fold by C] -C3- alkyl, hydroxy, CJ -C3 -alkoxy, fluorine or phenyl, or 1,2-cyclopropylene or C2-Cg-alkylene, wherein a methylene unit can be isosteπcally replaced by O, S, NR9, CO, SO or SO2, wherein the isostenc substitution, with the exception of =CO, cannot be adjacent to the amide group, and wherein R IS selected from hydrogen, Ci -Cg-alkyl, C3-C6-alkenyl, C3-C6-alkιnyl, Cj-Cg- acyl or Cj-Cg-alkylsulfonyl, D is selected from Ci -Ci Q-alkylene, optionally substituted once or twice by C] - Cβ-alkyl, hydroxy, or C ] -C6-alkoxy, 2- ιo- ιk en yl ene > which is optionally substituted once or twich by C j -Cg- alkyl, hydroxy, or C ] -Cg-alkoxy, wherein the double bond can also be to ring E, C3-C]o-alkιnylene, optionally substituted once or twice by Cj -Cό-alkyl, hydroxy, or C \ -C6-alkoxy, and Ci -Ci Q-alkylene, C2-C ] Q-alkenylene or C3-C ] o-alkιnylene, wherein one to three methylene units are each isostencally replaced by O, S, NR 0, CO, SO or SO2, wherein RlO has the same meaning as R^, but is selected independently therefrom, E is selected from (El) or (E2) wherein the heterocyclic ring can optionally have a double bond and n and p can be, independently of each other, 0, 1, 2 or 3, with the proviso that n + p < 4 and q is 2 or 3, Rl * is hydrogen, C\ -Cg-alkyl, hydroxy, hydroxymethyl, carboxy or C -C7- alkoxycarbonyl and R* 2 hydrogen, Ci -C6-alkyl or an oxo group adjacent to the nitrogen atom, wherein R Ϊ Ϊ and R* 2 optionally together form a C1-C3 -alkylene bridge under formation of a bi-cyclic ring system, G is selected from hydrogen, Gl, G2, G3, G4 and G5, wherein Gl represents the residue (CH 2 ) r (CR 1 R 15 )- R 13 wherein r is an integer from 1 to 3 or 0 and R* 3 is selected from hydrogen, Cj-C^-alkyl, C3-C6-alken l, C3-C6-alkιnyl, C3-C - cycloalkyl, saturated, five- to seven-membered heterocycles, which can contain one or two hetero-atoms from the group N and/or S and/or O, benzyl or phenyl, monocyclic aromatic five or six-membered heterocycles, which can contain one to three hetero-atoms from the group N and/or S and/or O and are either bound directly or over a methylene group, anellated bi- and tπcyclic aromatic or partially hydrated carbocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated heterocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from N and/or S and/or O and the linkage can occur either over an aromatic ring or a hydrated ring and either directly or over a methylene group, Rl4 has the same meaning as Rl 3 , but is selected independently thereof, Rl* IS selected from hydrogen, hydroxy, methyl, benzyl, phenyl, monocyclic aromatic five- or six-membered heterocycles, which can contain one to three hetero-atoms selected from the group N and/or S and/or O and are either bound directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated carbocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated heterocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from N and/or S and/or O and the linkage can occur either over an aromatic ring or a hydrated ring and either directly or over a methylene group, G2 is the residue (CH 2 ) r (CR 14 R 15 ) S R 13 (G2a) or (G2b) wherein the substituents R* 3 and R l * can have the above meaning or the grouping NR 13 R 15 can also be a nitrogen heterocycle bound over the nitrogen atom, selected from saturated or unsaturated monocyclic, four- to eight-membered heterocycles, which, aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from the group N and/or S and/or O, or saturated or unsaturated bi- or tricychc, anellated or bridged heterocycles with 8 to 16 ring atoms, which, aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from the group N and/or S and/or O, G3 is the residue S0 2 (CH 2 ) r R 13 (G3) and G4 is the residue (G4) wherein Ar* and Ar 2 are selected independently from one another from phenyl, pyridyl or naphthyl and G5 is the residue COR 16 (G5) wherein R* is selected from tnfluoromethyl, Cι -C6-alkoxy, C3-C6-alkenyloxy, or benzyloxy, and wherein aromatic ring systems in the substituents Rl, R 2 , R 4 , R* 3 , R 4 , R^, R*6 Ar-1 and Ar 2 and/or in the ring system -NR^R* can be substituted independently from each other by one to three of the same or different residues which are selected from halogen, cyano, C] -C6-alkyl, tnfluoromethyl, C3-Cg-Cycloalkyl, phenyl, benzyl, hydroxy, Cj- Cg-alkoxy, which can optionally be entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, Cj-C5-alkylthιo, carboxy, C \ -Cg-alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, mono-Ci-Cβ-alkylamino or dι-(Cι-C5-alkyl)-amιno and methylenedioxy for two adjacent groups on the aromatic ring or ring system, stereoisomers thereof and/or mixtures thereof and pharmacologically acceptable acid addition salts A further preferred embodiment of the invention constitutes compounds of the invention which are distinguished in that substituents R*, R 2 , R 3 , R 4 , R^, R*\ R 7 , R 8 R 9 , R 10 , R 13 , R 14 , R 15 and R 16 as well as A and D labelled therein have the following meaning in connection with the given substitutions according to this formula (i) wherein halogen is fluorine, chlorine, bromine or iodine, Cj-Cg-alkyl can be straight chain or branched and is preferably a methyl-, ethyl-, propyl-, isopropyl-, butyl-, isobutyl-, sec-butyl-, tert-butyl-, cyclopropylmethyl-, pentyl-, isopentyl-, tert-pentyl-, neopentyl-, cyclopropylethyl-, cyclobutylmethyl- or a hexyl group, alkylene is for example methylene, ethylene, propylene, tetramethylene, pentamethylene, hexamethylene, heptamethylene, octamethylene, nonamethylene or decamethylene, Cβ-Cg-alkenyl can be straight chain or branched and is preferably an allyl-, 2-butenyl-, 3-butenyl-, 2-methyl-2-propenyl-, 2-pentenyl-, 4-pentenyl-, 2-methyl-2-butenyl-, 3- methyl-2-butenyl-, 2-hexenyl-, 5-hexenyl-, 4-methyl-3-pentenyl- or 2,2-dimethyl-3- butenyl group, alkenylene is for example ethenylene, propenylene, butenylene, pentenylene, hexenylene, hexathenylene, heptenylene, octenylene, nonenylene or decenylene, Cβ-C -alkinyl can be straight chain or branched and is preferably a propargyl-, 2- butmyl-, 3-butinyl-, 4-pentinyl-, 5-hexinyl- or 4-methyl-2-pentinyl group, alkinylene is for example propinylene, butinylene, pentinylene, hexinylene, heptinylene, octinylene, noninylene or decinylene, Cβ-Cg-cycloalkyl is preferably cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl or cyclooctyl, Cι-C6-hydroxyaIkyI contains a hydroxyl group in one of the above-named C j -Cg- alkyl residues, especially in the form of the hydroxymethyl- and hydroxyethyl group, wherein C j -Cg-alkoxy, Cβ-Cg-alkenyloxy, Cs-Cβ-alkinyloxy each contain, aside from the oxygen atom, one of the Cι-C -alkyl-, C3-C6~alkenyl- and/or C3-C6-alkιnyl groups named above and the methoxy-, ethoxy-, isopropoxy-, tert-butoxy-, allyloxy- and propargyloxy group are preferred and is to be understood as among Cj -Cό-alkoxy entirely or partially substituted with fluorine, for example difluormethoxy, tπfluormethoxy or 2,2,2-tnfluorethoxy, Cj-Cg-alkylthio, C3-Cg-alkenylthio, Cβ-Cg-alkinylthio each contain, aside from the sulfur atom, one of the Cι-C6-alkyl-, C3-Cg-alkenyl- or C3-C6-alkιnyl group named above, especially the methylthio-, ethylthio-, isopropylthio- and tert-butylthio groups, C^-Cg-cycloalkyloxy and C -Cg-cycIoalkylthio are preferred as cyclopentyloxy- and cyclopentylthio- and/or cylohexyloxy- and cyclohexylthio groups, Cj-C7-alkanoyloxy groups contain, aside from the oxygen atom, an aliphatic acyl residue with 1 to 7 carbon atoms, especially the acetoxy-, propionyloxy- and pivaloyloxy group, C2-C7-alko y carbonyl groups contain, aside from the carbonyl group, one of the C] - Cβ-alkoxy groups mentioned above, especially the methoxycarbonyl-, ethoxycarbonyl-, lsopropoxycarbonyl-, isobutoxycarbonyl-and tert-butoxycarbonyl group, C2-C7-alkoxycarbonyloxy groups contain, aside from the oxygen atom, one of the C -C7-alkoxycarbonyl residues mentioned above, especially the methoxycarbonyloxy-, ethoxycarbonyloxy-, isopropoxycarbonyloxy-, lsobutoxycarbonyloxy-and tert- butoxycarbonyl group as well as the allyloxycarbonyloxy group, C2-C7-alkylaminocarbonyl and C3-Ci3-dialkyIaminocarbonyl groups contain, beside the carbonyl group, an alkylamino- and/or dialkylamino residue, whose C -Cg- alkyl groups have the above meanings, wherein the dimethylaminocarbonyl-, diethylaminocarbonyl- and the diisopropylaminocarbonyl groups are preferred, and aside from the unsubstituted amino group, one of the following Ci -Cg-alkylamino groups and/or dι-(Cι-C6-alkyl)amιno groups are to be understood under the amino groups of the formula NR^R^, Cj-Cg-alkylamino contains one of the C ] -C5-alkyl groups mentioned above, especially in form of the methylamino-, ethylamino-, propylammo-, isopropylamino-, butylamino- and the tert-butylamino group, d.-(Cι-C6-alkyl)amino carries two of the same or different of the above named C\ - Cg-alkyl groups on the nitrogen atom, especially in form of the dimethylamino-, diethylamino-, dipropylamino-, dnsopropylamino-, lsopropylmethylamino-, dibutylamino- or tert-butylmethylamino group, Cj-Cβ-acyl is the residue of an aliphatic saturated or unsaturated, straight chain, branched or cyclic carboxylic acid, especially in form of the formyl-, acetyl-, propionyl- , acryloyl-, butyryl-, isobutyryl-, methacryloyl-, cyclopropylcarbonyl-, pentanoyl-, pivaloyl-, cyclobutylcarbonyl-, hexanoyl- and the dimethylacryloyl group, Cj-Cg-alkansulfonyl is preferably the methanesulfonyl-, ethanesulfonyl-, propanesulfonyl-, butanesulfonyl-, pentanesulfonyl- and the hexanesulfonyl group, saturated five- to seven-membered heterocycles with one or two hetero-atoms are especially tetrahydrofuryl, tetrahydrothienyl, pyrrolidinyl, tetrahydropyranyl, piperidinyl, hexahydroazepinyl, piperazinyl, hexahydrodiazepinyl or morpholinyl, monocyclic aromatic five- or six-membered heterocycles with one to three hetero¬ atoms are especially furyl, thienyl, pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, imidazolyl, pyrazolyl, oxadiazolyl, thiadiazolyl, triazolyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl or triazinyl, anellated bi- and tricyclic aromatic or partially hydrated carbocycic ring systems with 8 to 16 ring atoms and at least one aromatic ring are preferably benzocyclobutyl, indanyl, indenyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, biphenylenyl, fluorenyl, anthryl, dihydroanthryl, phenanthryl, dihydrophenanthryl, dibenzocycloheptenyl, dihydrodibenzocycloheptenyl, dihydrodibenzocyclooctenyl or tetrahydrodibenzocyclooctenyl, wherein mono- or dioxo-derivates, wherein the residues of indanone, tetralone, anthrone, anthraquinone, fluorenone, phenanthrone, dibenzocycloheptenone, dihydrodibenzocycloheptenone or tetrahydrodibenzocyclooctenone are for example also to be understood as partially hydrated carbocyclic ring systems, anellated bi- and tricyclische aromatic or partially hydrated heterocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring are, for example, imidazothiazolyl, benzofuryl, dihydrobenzofuryl, benzothienyl, dihydrobenzothienyl, indolyl, indolinyl, benzimidazolyl, indazolyl, benzoxazolyl, benzisoxazolyl, benzo- thiazolyl, benzoisothiazolyl, benzofurazanyl, benzothiadiazolyl, benzotπazolyl, oxazolopyπdyl, thiazolopyndyl, lsothiazolopyπdyl, lmidazopyπdyl, pyrazolopyπdyl, thienopynmidinyl, chromanyl, benzopyranyl, quinolyl, isoquinolyl, dihydroqu olyl, tetrahydroqumolyl, benzodioxanyl, quinoxahnyl, quinazohnyl, naphthyπdinyl, carbazolyl, tetrahydrocarbazolyl, pyπdoindolyl, acπdinyl, phenothiazinyl, dihydrodibenzoxepinyl, benzocycloheptathienyl, dihydrothienobenzothiepmyl, dihydrodibenzothiepinyl, octahydrodibenzothiepinyl, dihydrodibenzazepinyl, octahydrodibenzazep yl, benzocycloheptapyndyl, dihydropyndobenzodiazepinyl, dihydrodibenzoxazepinyl, dihydropyndobenzoxepinyl, dihydropyπdobenzoxazepinyl, dihydrodibenzothiazepinyl or dihydropyπdobenzothiazepinyl, wherein their mono- or dioxo-derivates and/or optionally their possible tautomeres are also to be understood as partially hydrated heterocychc ring systems, for example, the residues of indolinone, isatin, benzoxazolone and/or its tautomeres hydroxybenzoxazol, of benzisoxazolone, benzothiazolone, benzoisothiazolone and benzimidazolone and/or their tautomeres, hydroxybenzisoxazol, hydroxybenzothiazol, hydroxybenzoisothiazol and hydroxybenzimidazol, of lndazohnone, of oxazolopyndinone, thiazolopyπdinones, pyrazolopyndinones and lmidazopyπdinones and/or their tautomeres hydroxyoxazolopyπdine, hydroxythiazolopyndines, hydroxypyrazolopyπdines and hydroxyimidazopyndines, the residues of chromanone, chromone, qumohnone, di- hydroquinohnone, tetrahydrocarbazolone, acndone, of dihydrodibenzoxepinones, benzocycloheptathiophenones, dihydrothienobenzothiepinones, dihydrodibenzo- thiepmones, dihydrodibenzoazepinones, benzocycloheptapyndinones, dihydropyπdo- benzoxazepinones, dihydrodibenzothiazepinones and of dihydropyπdobenzothiazepi- nones, saturated and unsaturated monocyclic, four- to eight-membered heterocycles are NR ' 3 R 15 as a grouping which, aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from N and/or S and/or O, for example azetidine, pyrrohdine, piperidine, (lH)tetrahydropyπdιne, hexahydroazepme, (lH)tetrahydroazepιne, octahydroazocine, pyrazolidine, piperazine, hexahydrodiazepine, morphohne, hexahydrooxazepine, thiomorphohne or thiomorphohne- 1 , 1 -dioxide, saturated or unsaturated bi- or tricyclic, anellated or bridged heterocycles with 8 to 16 ring atoms, represent NR 13 R 15 as a grouping which, aside from the essential nitrogen atom optionally contain one or two further hetero-atoms, selected from N and/or S and/or O, for example 5-aza-bιcyclo[2 1 1 jhexane, 2-aza- bιcyclo[2 2 Ijheptane, 7-aza-bιcyclo[2 2 Ijheptane, 2,5-dιaza-bιcyclo[2 2 Ijheptane, 2- aza-bιcyclo[2 2 2]octane, 8-aza-bιcyclo[3 2 ljoctane, 2,5-dιaza-bιcyclo[2 2 2]octane, 9-aza-bιcyclo[3 3 ljnonane, indoline, isoindoline, (lH)-dιhydroquιnolιne, (1H)- tetrahydroqumohne, (2H)-tetrahydroιsoqumolιne, (lH)-tetrahydroquιnoxahne, (4H)- dihydrobenzoxazine, (4H)-dιhydrobenothιazιne, (1 H)-tetrahydrobenzo[b]azepιne, (1 H)-tetrahydrobenzo[c]azepιne, (1 H)-tetrahydrobenzo[d]azepιne, (5H)-tetrahydroben- zo[b]oxazepιne, (5H)-tetrahydrobenzo[b]thιazepιne, l,2,3,4-tetrahydro-9H-pyπdo[3,4- b]ιndol, (lOH)-dιhydroacndιne, 1,2,3,4-tetrahydroacrιdanone, (lOH)-phenoxazιn, (l OH)-phenothιazιne, (5H)-dιbenzazepιne, (5H)-dιhydrodιbenzazepιne, (5H)- octahydrodibenzazepine, (5H)-dιhydrodιbenzodιazepme, (11H)- dιhydrodιbenzo[b,e]oxazepιne, (1 lH)-dιhydrodιbenzo[b,e]thιazepιne, (lOH)-dιhydro- dιbenzo[b,f]oxazepιne, (10H)-dιhydrodιbenzo[b,fjthιazepιne or (5H)- tetrahydrodibenzazocine, as well as optionally possible tautomeres in the case of substitution of the heterocycle as such or in an anellated ring system by free hydroxy-, mercapto- and/or amino groups, and stereoisomers such as, if applicable, cis/trans-isomers, endo/exo-isomers, optic isomers such as enantiomers, diastereomers as pure isomers or mixtures and/or racemic mixtures as well as the pharmacologically acceptable acid addition salts with inorganic or organic acids, wherein the hydrochlondes, hydrobromides, hydroiodides, sulfates and phosphates, are preferred as addition salts with suitable inorganic acids and acetates, benzoates, 4-methoxybenzoate, 2- or 4-hydroxybenzoate, 4-chlorobenzoate, ascorbate, sahcylate, formiate, glutarate, tncarballylate, citrates, fumarates, gluconates, malates, maleates, methanesulfonates, lactates, oxalates, succinates, tartrates and toluolsulfonates, for example p-toluolsulfonate are preferred as addition salts of organic acids Compounds in which the substitutents labelled in formula (I) (I) have the following meanings, are especially preferred R is hydrogen, halogen, cyano, Ci -Cg-alkyl, tnfluoromethyl, C3-Cg-cycloalkyl, C]-C4-hydroxyalkyl, hydroxy, C]-C4-alkoxy, benzyloxy, Cj -C^alkanoyloxy, C i -C4-alkylthιo, C -C 5 -alkoxycarbonyl, aminocarbonyl, C3-C9- dialkylaminocarbonyl, carboxy, phenyl, phenoxy, pyndyloxy or NR*R", wherein R 5 and R are selected independently from each other form hydrogen and C 1 -Cg-alkyl, R 2 is hydrogen, halogen, Cj -Cg-alkyl, tnfluoromethyl or hydroxy, wherein Rl and R 2 , in the case they are adjacent, optionally form a bridge which are selected from the group of bridge members -(CH 2 )4- and -(CH=CH)2~ and - CH 2 O-CR 7 R 8 -O-, wherein R 7 and R 8 can be, independently from each other, hydrogen and Ci -Cg-alkyl, R 3 is selected from hydrogen, halogen and C]-C6-alkyl and R 4 is selected from hydrogen, Cι -C6-alkyl, C3-C6-alkenyl, hydroxy, Cj-Cg-alkoxy and benzyloxy, k is 0 or 1, A is selected from C^-Cg-alkylene, which is optionally substituted once to three¬ fold by Cj-C3-alkyl, hydroxy, fluorine or phenyl, 1,2-cyclopropylene, or C2-C6-alkylene, wherein a methylene unit can be isostencally replaced by O, S, NR 9 , CO, SO or SO2, and wherein the isostenc substitute, with the exception of =CO, cannot be adjacent to the amide group, and wherein R 9 IS hydrogen, Cι -C3-alkyl, C j -Cg-acyl or methanesulfonyl, D is selected from C]-Ci ()-alkylene, which is optionally substituted once or twice by Cj-C3-alkyl or hydroxy, C 2 ~C 1 o-alkenylene, optionally substituted once or twice by Ci -C3-alkyl or hydroxy, wherein the double bond can also be to ring E or 3-Ci0" a h ιnylene, which is optionally substituted once or twice by C1-C3- alkyl or hydroxy, and can be selected as well from C j -Cio-alkylene, C2-Cι o-alkenylene or C3-Cj o-alkιnylene, in which one to three methylene units are isostencally replaced by O, S, NR^, CO, SO or SO2, wherein RΪO has the same meaning as R 9 , but is selected independently therefrom, E is (El) or (E2), wherein the heterocychc ring can optionally have a double bond and n and p can be, independent of each other, 0, 1 , 2 or 3, with the proviso that n + p < 4, q is 2 or 3, R Ϊ 1 is selected from hydrogen, C\ -C3-alkyl, hydroxy, hydroxymethyl, carboxy or C2-C7-alkoxycarbonyl and Rl 2 IS selected from hydrogen or an oxo group adjacent to the nitrogen atom, G is selected from hydrogen, Gl, G2, G3, G4 and G5, wherein Gl represents the residue (CH 2 ) r (CR 14 R 15 ) S R 13 (Gl) wherein s is 0 or 1 , R* 3 is selected from hydrogen, Ci-Cg-alkyl, C3-C6-alkenyl, C3-Cg-alkιnyl, C3-C8- cycloalkyl, benzyl, phenyl, monocyclic aromatic five- or six-membered heterocycles, which contain one to three hetero-atoms from the group N and/or S and/or O and are either bound directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated carbocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, whereby the bond can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated heterocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from the groups N and/or S and/or O and the bond can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, Rl 4 has the same meaning as R* 3 , but is selected independently thereof, R Ϊ is selected from hydrogen, hydroxy, methyl, benzyl or phenyl, monocyclic aromatic five- or six-membered heterocycles, which can contain one to three hetero-atoms selected from the group N and/or S and/or O and are bound either directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated carbocychc ring systems with 8 to 16 ring atoms and at least einem aromatic ring, wherein the bond can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated heterocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from the group N and/or S and/or O and the bond can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, G2 is selected from the residues C (CH 2 ) r (CR 14 R 15 ) S R 13 0 (G2a) and C (CH 2 ) r NR 13 R 15 O (G2b), wherein the substituents R* 3 and R * the can have the above meaning, or the grouping NR 13 R 15 can also be a nitrogen heterocycle bound over the nitrogen atom, selected from saturated or unsaturated monocyclic, four- to eight-membered heterocycles, which, aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from N and/or S and/or O, or saturated or unsaturated bi- or tricychc, anellated or bridged heterocycles with 8 to 16 ring atoms, which, aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from N and/or S and/or O, G3 is the residue S0 2 (CH 2 ) r R (G3), G4 is the residue V Ar1 (G4), wherein Ar^ and Ar 2 are selected independently of each other from phenyl, pyridyl or naphthyl, G5 is the residue wherein R* is tnfluoromethyl, C i -Cg-alkoxy, C3-C6-alkenyloxy or benzyloxy and aromatic ring systems in which the substituents R , R 2 , R 4 , R* 3 , R* 4 , R* , R* , Ar* and Ar 2 and/or in the ring system -NR^ R^ can carry independently of each other one to three of the same or different substituents from the series halogen, cyano, Ci-Cg-alkyl, tnfluoromethyl, C3-Cg-cycloalkyl, phenyl, benzyl, hydroxy, C i -Cg-alkoxy, which is optionally entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, Ci-Cg-alkylthio, carboxy, C j -C^-alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, mono-C] - Cg-alkylamino, di-(Cι -C6-alkyl)-amino, wherein two adjacent groups on the aromatic ring or ring system can form an additional ring over a methylenedioxy bridge. Compounds in which the substiutents labelled in formula (I) (i) have the following meanings are particularly preferred: RΪ is hydrogen, halogen, cyano, methyl, tnfluoromethyl, hydroxy, C] -C4-alkoxy, ethylthio, methoxycarbonyl, tert-butoxycarbonyl, aminocarbonyl, carboxy, and phenoxy, R 2 is hydrogen, halogen, tnfluoromethyl or hydroxy, R 3 is hydrogen or halogen, R 4 is selected from hydrogen, Cι -C3-alkyl, hydroxy and C]-C3-alkoxy, k is 0 or 1 , A is C2-Cg-alkylene, which is optionally substituted once or twice by C \ -C3- alkyl, hydroxy or fluorine, as well as 2"C6-alkylene, wherein a methylene unit can be isostencally replaced by O, S, CO or SO2, and the isosteric substitute, with the exception of =CO, cannot be adjacent to the amide group, D is C] -Cg-alkylene, which is optionally substituted once twice by methyl or hydroxy, C2-Cg-alkenylene, which is optionally substituted once or twice by methyl or hydroxy, wherein the double bond can also be to ring E, C3-Cg-alkιnylene, which is optionally substituted once or twice by methyl or hydroxy, as well as C i -Cg-alkylene, C2-Cg-alkenylene or C3-Cg-alkιnylene, in which one to three methylene units can be isostencally replaced by O, S, NH, N(CH3), N(COCH 3 ), N(SO 2 CH 3 ), CO, SO or SO 2 , or (E2) wherein the heterocychc ring can optionally have a double bond and n and p can be independent of each other 0, 1 , 2 or 3, with the proviso that n + p < 3, q is 2 or 3, RU is selected from hydrogen, Cj-C3-alkyl, hydroxy, hydroxymethyl and R* 2 is selected from hydrogen or an oxo group which is adjacent to the nitrogen atom, G is hydrogen or Gl, G2, G3, G4 and G5, wherein Gl represents the residue (CH 2 ) r (CR 14 R 15 ) S R 13 (Gl) wherein Rl 3 is selected from hydrogen, Ci -Cg-alkyl, C3-Cg-cycloalkyl, benzyl or phenyl, benzocyclobutyl, indanyl, indenyl, oxoindanyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, oxotetrahydronaphthyl, biphenylenyl, fluorenyl, oxofluorenyl, anthryl, dihydroanthryl, oxodihydroanthryl, dioxodihydroanthryl, phenanthryl, dihydrophenanthryl, oxodihydrophenanthryl, dibenzocycloheptenyl, oxodibenzocycloheptenyl, dihydrodibenzocycloheptenyl, oxodihydrodibenzocycloheptenyl, dihydrodibenzocyclooctenyl, tetra- hydrodibenzocyclooctenyl and oxotetrahydrodibenzocyclooctenyl, bound directly or over a methylene group, furyl, thienyl, pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, tπazolyl, pyridyl, pyrazinyl, pyπdazinyl, pyπmidinyl, tnazinyl, lmidazothiazolyl, benzofuryl, dihydrobenzofuryl, benzothienyl, dihydrobenzothienyl, mdolyl, indolinyl, oxomdolinyl, dioxoindohnyl, benzoxazolyl, oxobenzoxazohnyl, benzisoxazolyl, oxobenzisoxazohnyl, benzothiazolyl, oxobenzthiazolmyl, benzoisothiazolyl, oxobenzoisothiazohnyl, benzimidazolyl, oxobenzimidazohnyl, indazolyl, oxoindazohnyl, benzofurazanyl, benzothiadiazolyl, benzotnazolyl, oxazolopyridyl, oxodihydrooxazolopyridyl, thiazolopyndyl, oxodihydrothiazolopyridyl, isothiazolopyridyl, lmidazopyπdyl, oxodihydroimidazopyndyl, pyrazolopyridyl, oxodihydropyrazolopyridyl, thienopynmidinyl, chromanyl, chromanonyl, benzopyranyl, chromonyl, quinolyl, isoquinolyl, dihydroquinolyl, oxodihydroquinohnyl, tetrahydroquinolyl, oxotetrahydroquinohnyl, benzodioxanyl, quinoxahnyl, quinazolinyl, naphthyπdinyl, carbazolyl, tetrahydrocarbazolyl, oxotetrahydrocarbazolyl, pyndoindolyl, acπdinyl, oxodihydroacπdinyl, phenothiazinyl, dihydrodibenzoxepinyl, oxodihydrodibenzoxepinyl, benzocycloheptathienyl, oxobenzocycloheptathienyl, dihydrothienobenzo- thiepinyl, oxodihydrothienobenzothiepinyl dihydrodibenzothiepinyl, oxodihydrodibenzothiepinyl, octahydrodibenzothiepinyl, dihydrodibenzazepinyl, oxodihydrodibenzazepmyl, octahydrodibenzazepinyl, benzocycloheptapyπdyl, oxobenzocycloheptapyπdyl, dihydropyπdo- benzodiazepinyl, dihydrodibenzoxazepinyl, dihydropyπdobenzoxepinyl, dihydropyπdobenzoxazepinyl, oxodihydropyπdobenzoxazepinyl, dihydrodibenzothiazepinyl, oxodihydrodibenzothiazepinyl, dihydropyridobenzothiazepinyl, oxodihydropyridobenzothiazepinyl, bound directly or over a methylene group, Rl 4 has the same meaning as R* 3 , but is selected independently therefrom, R15 is selected from hydrogen, hydroxy, methyl, benzyl or phenyl, indanyl, indenyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, furyl, thienyl, pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, triazinyl, benzofuryl, benzothienyl, indolyl, indolinyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, chromanyl, quinolyl or tetrahydroquinolyl bound directly or over a methylene group, G2 is selected from the residues C (CH 2 ) r (CR 14 R 15 ) S R 13 (G2a) and (G2b) wherein the substituents R* 3 and R l * can have the above meanings, or represents the grouping NR 13 R 15 each over the nitrogen-bound ring atom of azetidine, pyrrolidine, piperidine, (lH)tetrahydropyridine, hexahydroazepine, (lH)tetrahydroazepine, octahydroazocine, pyrazolidine, piperazine, hexyhydrodiazepine, morphohne, hexahydrooxazepine, thiomorphohne, thiomorphohne- 1 ,1 -dioxide, 5-aza-bι- cyclo[2 1 l jhexane, 2-aza-bιcyclo[2 2 Ijheptane, 7-aza-bιcyclo[2 2 Ijheptane, 2,5-dιaza-bιcyclo[2 2 Ijheptane, 2-aza-bιcyclo[2 2 2Joctane, 8-aza-bιcyc- lo[3 2 ljoctane, 2,5-dιazabιcyclo[2 2 2Joctane, 9-azabιcyclo[3 3 1 jnonane, indoline, lso doline, (lH)-dιhydroquιnohne, (lH)-tetrahydroquιnohne, (2H)- tetrahydroisoquinohne, (1 H)-tetrahydroquιnoxahne, (4H)-dιhydrobenzoxazιne, (4H)-dιhydrobenzothιazιne, (lH)-tetrahydrobenzo[b]azepιne, ( 1 H)-tetrahydro- benzo[cjazepιne, (lH)-tetrahydrobenzo[d]azepιne, (5H)- tetrahydrobenzo[bjoxazepιne, (5H)-tetrahydrobenzo[bjthιazepιne, 1 ,2,3,4- tetrahydro-9H-pyndo[3,4-bjιndole, (lOH)-dιhydroacndιne, 1,2,3,4-tetrahydro- acndanone, (l OH)-phenoxazιne, (lOH)-phenothιazιne, (5H)-dιbenzazepιne, (5H)-dιhydrodιbenzazepιne, (5H)-Octahydrodιbenzazepιne, (5H)- dihydrodibenzodiazepine, (1 l H)-dιhydrodιbenzo[b,ejoxazepιne, (1 lH)-dιhydro- dιbenzo[b,e]thιazepιne, (10H)-dιhydrodιbenzo[b,f]oxazepιne, (10H)- dιhydrodιbenzo[b,fjthιazepιne or (5H)-tetrahydrodιbenzazocιne, G3 is the residue S0 2 (CH 2 ) r R1 3 (G3), G4 is the residue V Ar1 ° * \ Ar * (G4), wherein Ar^ and Ar 2 are selected independently of each other from phenyl, pyridyl or naphthyl, G5 is the residue COR 16 (G5) wherein Rl6 is trifluoromethyl, Cj-Cg-alkoxy, C3-C($-alkenyloxy or benzyloxy and aromatic ring systems in which the substituents can be substituted independently of each other by one to three of the same or different substituents from the series halogen, cyano, Cj-Cg-alkyl, trifluoromethyl, C3-Cg- Cycloalkyl, phenyl, benzyl, hydroxy, C] -C6-alkoxy, Cj -Cg-alkoxy, which can be entirely or partially substituted by fluorine, can carry benzyloxy, phenoxy, mercapto, C ] -Cg-alkylthio, carboxy, Ci -Cg-alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, mono-Ci -Cβ-alkylamino, di-(C] -C6-alkyl)- amino, wherein two adjacent groups can form an additional ring with a methylenedioxy bridge. A further preferred embodiment of the invention comprises compounds which are distinguished in that the substituents labelled in formula (I) (I) have the following meaning: Rl is hydrogen, halogen, cyano, methyl, trifluoromethyl, hydroxy, methoxy or methoxycarbonyl , R 2 is hydrogen or halogen, R 3 is hydrogen, R 4 is selected from hydrogen, Cι -C3-alkyl or hydroxy, k is 0 or 1, A is selected from C2-C6-alkylene, which is optionally substituted once or twice by hydroxy or fluorine and C2-C6-alkylene, wherein a methylene unit can be isostencally replaced by O, S or CO, and the isosteric substitute, with the exception of =CO, cannot be adjacent to the amide group and, D is C2-Cg-alkylene, which is optionally substituted by methyl or hydroxy, C2-Cg-alkenylene, which is optionally substituted by methyl or hydroxy, wherein the double bond can also be to ring E, or C2-Cg-alkylene, C2-Cg-alkenylene, wherein one to three methylene units can be isostencally replaced by O, NH, N(CH 3 ), N(COCH 3 ), N(SO 2 CH ) or CO, E is selected from the residues (El) or (E2), wherein the heterocychc ring can optionally have a double bond and n and p can be, independent of each other, 0, 1 , 2 or 3, with the proviso that n + p < 3 and q is 2 RΪ* is hydrogen, methyl or hydroxyl and Rl 2 is hydrogen or an oxo group adjacent to the nitrogen atom, G is selected from hydrogen, C3-Cg-cycloalkyl, methoxycarbonyl, tert- butoxycarbonyl, benzyloxycarbonyl, trifluoroacetyl, diphenylphosphinoyl or the residues (CH 2 ) r (CR 14 R 15 ) S R 13 (Gl) and C (CH 2 ) r (CR 14 R 15 ) £ ,13 II o (G2a) and C (CH 2 ) r NR 13 R 15 O (G2b) and S0 2 (CH 2 ) r R 13 (G3) wherein r is 0, 1 or 2 and s is 0 or 1. R 3 is hydrogen, methyl, benzyl or phenyl, indanyl, indenyl, oxoindanyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, oxotetrahydronaphthyl, fluorenyl, oxofluorenyl, anthryl, dihydroanthryl, oxodihydroanthryl, dioxodihydroanthryl, dibenzocycloheptenyl, oxodibenzo¬ cycloheptenyl, dihydrodibenzocycloheptenyl, oxodihydrodibenzocycloheptenyl bound directly or over a methylene group, furyl, thienyl, pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, tπazolyl, pyridyl, pyrazinyl, pyπdazinyl, pyπmidmyl, lmidazothiazolyl, benzofuryl, dihydrobenzofuryl, benzothienyl, dihydrobenzothienyl, indolyl, indohnyl, oxoindohnyl, dioxoindohnyl, benzoxazolyl, oxobenzoxazohnyl, benzisoxazolyl, oxobenzisoxazohnyl, benzothiazolyl, oxobenzthiazohnyl, benzoisothiazolyl, oxobenzoisothiazolinyl, benzimidazolyl, oxobenzimidazohnyl, benzofurazanyl, benzothiadiazolyl, benzotπazolyl, oxazolopyπdyl, oxodihydrooxazolopyπdyl, thiazolopyπdyl, oxodihydrothiazolopyπdyl, lsothiazolopyπdyl, lmidazopyπdyl, oxodihydro- lmidazopyπdyl, pyrazolopyπdyl, thienopynmidinyl, chromanyl, chromanonyl, benzopyranyl, chromonyl, quinolyl, isoquinolyl, dihydroqumolyl, oxodihydroquinohnyl, tetrahydroquinolyl, oxotetrahydroquinohnyl, benzodioxanyl, quinoxahnyl, quinazohnyl, naphthyπdmyl, carbazolyl, tetrahydrocarbazolyl, oxotetrahydrocarbazolyl, pyπdoindolyl, acπdinyl, oxodihydroacridinyl, phenothiazmyl, dihydrodibenzoxepinyl, benzocyclohepta- thienyl, oxobenzocycloheptathienyl, dihydrothienobenzothiepinyl, oxodihydro- thienobenzothiepinyl dihydrodibenzothiepinyl, oxodihydrodibenzothiepmyl, dihydrodibenzazepinyl, oxodihydrodibenzazepmyl, octahydrodibenzazepinyl, benzocycloheptapyπdyl, oxobenzocycloheptapyπdyl, dihydropyπdobenzoxepinyl, dihydrodibenzothiazepinyl, oxodihydrodibenzothiazepinyl bound directly or over a methylene group, Rl 4 is hydrogen, methyl, benzyl or phenyl, Rl* is selected from hydrogen, hydroxy, methyl, benzyl, phenyl, naphthyl, furyl, thienyl, oxazolyl, thiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, pyridyl, benzofuryl, benzothienyl, dolyl, indohnyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, chromanyl, quinolyl or tetrahydroquinolyl, bound directly or over a methylene group, wherein in formula (I) the group NR™R 15 can also be selected from pyrrolidine, piperidine, (lH)tetrahydropyπdιne, hexahydroazepme, Octahydroazocine, piperazine, hexa- hydrodiazepme, morpholme, hexahydrooxazepine, 2-azabιcyclo[2 2 I jheptane, 7-azabιcyclo[2 2 Ijheptane, 2,5-dιazabιcyclo[2 2 Ijheptane, 8- azabιcyclo[3 2 1 joctane, 2,5-dιazabιcyclo[2 2 2Joctane, indoline, isoindoline, (1 H)-dιhydroquιnohne, (1 H)-tetrahydroquιnohne, (2H)-tetrahydroιsoquιnohne, (lH)-tetrahydroquιnoxahne, (4H)-dιhydrobenzoxazme, (4H)- dihydrobenzothiazine, (1 H)-tetrahydrobenzo[bJazepιne, (1 H)-tetrahydroben- zo[d]azepιne, (5H)-tetrahydrobenzo[bjoxazepιne, (5H)- tetrahydrobenzo[bjthιazepιne, l,2,3,4-tetrahydro-9H-pyπdo[3,4-bjιndol, (10H)- dihydroacπdine, 1 ,2,3,4-tetrahydroacπdanone, (5H)-dιhydrodιbenzazepιne, (5H)-dιhydrodιbenzodιazepιne, (1 lH)-dιhydrodιbenzo[b,e]oxazepιne, (1 1 H)- dιhydrodιbenzo[b,e]thιazepme, (10H)-dιhydrodιbenzo[b,fjoxaze-pιne or (5H)- tetrahydrodibenzazocine Compounds in which the labelled substituents in the formula (I) (I) have the following meanings are very particularly preferred R Ϊ is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl or hydroxy, R 2 and R 3 are hydrogen, R 4 is hydrogen or hydroxy, A is selected from C2-Cg-alkylene, which is optionally substitued once or twice by hydroxy or fluorine, D is selected from C2-C6-alk lene, C2-Cg-alkenylene, wherein the double bond can also be to ring E, and C2-Cg-alkylene and C 2 -C6-alkenylene, wherein a methylene unit can be isosterically replaced by O, NH, N(CH3) or CO or an ethylene group can be isosterically replaced by NH-CO and/or CO-NH or a propylene group can be isostencally replaced by NH-CO-O and/or O-CO-NH, E is selected from pyrrolidine, piperidine, 1,2,5,6-tetrahydropyridine, hexahydroazepme, morpholine and hexahydro-l,4-oxazepine, wherein the heterocychc ring optionally adjacent to the nitrogen atom, can be substituted by an oxo group, G is selected from hydrogen, tert-butoxycarbonyl, diphenylphosphinoyl, or one of the residues (CH 2 ) r (CR 14 R 1S ) S R 13 (Gl) and C (CH 2 ) r (CR 14 R 15 ) S ,13 II o (G2a) and C (CH 2 ). NR 13 R 15 II (G2b) and S0 2 (CH 2 ) r R1 3 (G3) wherein r is 0 or 1 and s is 0 or 1 , R l3 is hydrogen, methyl, benzyl or phenyl, indenyl, oxoindanyl, naphthyl, tetrahydronaphthyl, fluorenyl, oxofluorenyl, anthryl, dihydroanthryl, oxodihydroanthryl, dioxodihydroanthryl, dibenzocycloheptenyl, dihydrodibenzocycloheptenyl bound directly or over a methylene group, furyl, thienyl, oxazolyl, thiazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, pyridyl, pyrazinyl, pyrimidinyl, imidazothiazolyl, benzofuryl, benzothienyl, indolyl, oxoindohnyl, dioxoindohnyl, benzoxazolyl, oxobenzoxazohnyl, benzothiazolyl, oxobenzthiazohnyl, benzimidazolyl, oxobenzimidazohnyl, benzofurazanyl, benzotπazolyl, oxazolo pyridyl, oxodihydrooxazolopyπdyl, thiazolopyπdyl, oxodihydrothiazolopyπdyl, chromanyl, chromanonyl, benzopyranyl, chromonyl, quinolyl, isoquinolyl, oxodihydroquinohnyl, tetrahydroquinolyl, oxotetrahydro- quinohnyl, benzodioxanyl, quinazolinyl, acπdinyl, oxodihydroacridinyl, phenothiazmyl, dihydrodibenzoxepinyl, benzocycloheptathienyl, dihydro- thienobenzothiepinyl, dihydrodibenzothiepinyl, oxodihydrodibenzothiepinyl, dihydrodibenzazepinyl, oxodihydrodibenzazepmyl, octahydrodibenzazepinyl, benzocycloheptapyπdyl, oxobenzocycloheptapyndyl, dihydrodibenzothiazepinyl bound directly or over a methylene group, R^ 4 is hydrogen, methyl, benzyl or phenyl, Rl* IS hydrogen, hydroxy, methyl, benzyl or phenyl, naphthyl, furyl, thienyl, pyridyl, benzofuryl, benzothienyl, mdolyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, chromanyl, quinolyl or tetrahydroquinolyl bound directly or over a methylene group, wherein in the formula C (CH 2 ) r NR 13 R 15 O (G2b) the group NR 13 R 15 can be selected from pyrrolidine, piperidine, hexahydroazepme, morpholme, 2,5-dιazabιcyclo[2 2 I jheptane, indoline, isoindohne, (IH)-dihydroquinohne, (lH)-tetrahydroquιnohne, (2H)-tetrahydro- lsoquinohne, (lH)-tetrahydrobenzo[bjazepιne, (lH)-tetrahydrobenzo[djazepιne, (5H)-tetrahydrobenzo[bjoxazepιne, (5H)-tetrahydrobenzo[bjthιazepιne, 1 ,2,3,4- tetrahydroacπdanone, (5H)-dιhydrodιbenzazepιne, (1 l H)-dιhydrodιbenzo[b,ej- oxazepme or (1 lH)-dιhydrodιbenzo[b,ejthιazepιne and wherein aromatic ring systems in the substituents can be substituted, independently of each other, by one to three of the same or different substituents from the series halogen, cyano, C]-C6-alkyl, tnfluoromethyl, C3-Cg-cycloalkyl, phenyl, benzyl, hydroxy, C \ -Cg-alkoxy, C]-C6-alkoxy, which can be entirely or partially substituted by fluorine, can carry benzyloxy, phenoxy, mercapto, C j - Cg-alkylthio, carboxy, Cι-C6-alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, mono-Cι-C6-alkylamιno or dι-(Cι-C5-alkyl)-amιno, whereby two adjacent groups on the aromatic ring or ring system for an additional ring over a methylenedioxy bridge Compounds are especially preferred which distinguish themselves in that the substituents labelled in the formula (I) (i) have the following meanings Rl is hydrogen, fluorine, methyl, tnfluoromethyl or hydroxy, R 2 and R 3 are hydrogen, R 4 is hydrogen or hydroxy, A is selected from ethylene, propylene or butylene optionally substituted by hydroxy or one or two fluorine atoms, D is selected from C2"C6-alkylene or C2-C6-alken lene, wherein the double bond can also be to ring E, E is selected from pyrrolidine, piperidine, hexahydroazepme or morpholme, G is selected from benzyl, phenethyl, fluorenylmethyl, anthrylmethyl, diphenylmethyl, fluorenyl or dihydrodibenzocycloheptenyl, furylmethyl, thienylmethyl, thiazolylmethyl, pyπdylmethyl, benzothienylmethyl, quinolylmethyl, phenyl-thienylmethyl, phenyl-pyπdylmethyl, dihydrodibenzoxepinyl, dihydrodibenzothiepinyl, acetyl, pivaloyl, phenylacetyl, diphenylacetyl, diphenylpropionyl, naphthylacetyl, benzoyl, naphthoyl, anthrylcarbonyl, oxofluorenylcarbonyl, oxodihydro- anthrylcarbonyl or dioxodihydroanthrylcarbonyl, furoyl, pyπdylcarbonyl, chromonylcarbonyl, quinolylcarbonyl, naphthylaminocarbonyl, dibenzylaminocarbonyl, benzylphenylaminocarbonyl, diphenylaminocarbonyl, indohnyl- 1 -carbonyl, dihydrodibenzazepin-N-carbonyl, tetrahydroquinohnyl-N-carbonyl, tetrahydrobenzo[b]azepιnyl-N-carbonyl, methanesulfonyl, phenylsulfonyl, p-toluolsulfonyl, naphthylsulfonyl, quinohnsulfonyl and diphenylphosphinoyl, wherein aromatic ring systems can be substituted independently of each other by one to three of the same or different substituents from the series halogen, cyano, C] -C6-alkyl, tnfluoromethyl, C3-Cg-cycloalkyl, phenyl, benzyl, hydroxy, Cj-Cg-alkoxy, C j -Cg-alkoxy, which can be entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, C \ -Cg-alkylthio, carboxy, C i -Cg-alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, mono-Cj - C6-alkylamιno or dι-(Cι -Cg-alky -amino, wherein two adjacent groups in the ring or ring system can form an additional ring over a methylendioxy bridge A series of exemplary compounds with the respective substituent definitions are listed in the following Table 1 for illustration of the invention without restricting the scope of the compounds according to the invention Table 1 : Exemplifying compounds of formula (I) according to the invention Table 1 (continued) 52 Table 1 (continued) Table 1 (continued) -54- Table 1 (continued) Table 1 (continued) Table 1 (continued) Table 1 (continued) -58- Table 1 (continued) Table 1 (continued) -60 Table 1 (continued) 61 Table 1 (continued) Table 1 (continued) -63 Table 1 (continued) -64- Table 1 (continued) 65- Table 1 (continued) Table 1 (continued) 67- Table 1 Ccontinued) Table 1 (continued) -69 Table 1 (continued) 70 Table 1 (continued) -71 - Table 1 (continued) Table 1 (continued) Table 1 (continued) 74- Table 1 (continued) 75 Table 1 (continued) 76- Table 1 (continued) 77- Table 1 (continued) SYNTHESIS METHODS Further subject-matter of the invention are analogous methods for the production of the compounds of formula (I) according to the invention. Method (A): Compounds of formula (I) are (a) obtained by reacting carboxylic acids of formula (II) <°> (II) in which R R^, R3 5 A and have the meaning described above or their reactive derivatives are reacted with compounds of formula (III) H N- (III) wherein D, E, G and R^ also have the above described meanings. Reactive derivatives of compound (II) can be, for example, activated esters, anhydrides, acid halides (especially acid chlorides) or simple low alkyl esters. Suitable acitivated esters are, for example, p-nitrophenyl ester, 2,4,6-trichlorophenyl ester, pentachlorophenyl ester, cyanomethyl ester, esters of N-hydroxysuccinimide, of N- hydroxyphthalimides, of 1 -hydroxybenzotπazol, of N-hydroxypipeπdine, of 2- hydroxypyπdine or of 2-mercaptopyπdιne, etc Anhydrides can be symmetric anhy¬ drides or mixed, as they are obtained, for example, with pivaloyl chloride or with chloroformates Aromatic (for example chloroformic phenyl ester), araliphatic (for example chloroformic benzyl ester) or aliphatic chloroformates (for example chloroformic methyl ester, -ethyl ester or -isobutyl ester) can be used for this Reaction of compounds (II) with compounds (III) can also be carried out in the presence of condensation agents such as dicyclohexylcarbodiimide, l-ethyl-3-(3-dι- methylamιnopropyl)carbodπmιde hydrochloπde, N,N'-carbonyldnmιdazol, 1 - ethoxycarbonyl-2-ethoxy-l ,2-dιhydroquιnolιne, etc If carbodnmides are used as the condensation agent, reagents such as N-hydroxysuccinimide, N-hydroxyphthahmide, 1 - hydroxybenzotπazol, N-hydroxypipeπdme, etc can be advantageously added Compounds of formula (III) can be used for reaction as free bases as well as in the form of their acid addition salts For this, the salts of inorganic acids are to be preferred, 1 e hydrochloπdes, hydrobromides or sulfates Reaction of compounds (II) or their reactive derivatives with compounds (III) are normally carried out in a suitable, preferably inert solvent As examples, aromatic hydrocarbons such as benzene, toluene, xylene, halogenated hydrocarbons (for example dichloromethane, chloroform, 1,2-dιchloroethane, tπchloroethylene), ether (for example diethyl ether, tetrahydrofuran, dioxane, glycol dimethyl ether), ethyl acetate, acetonitπle or polar aprotic solvents such as, for example, dimethylsulfoxide, dimethylformamide or N-methylpyrrohdone are to be named Pure solvents, as well as mixtures of two or more, can be used The reaction is optionally carried out in the presence of an auxiliary base Suitable examples for this are alkali metal carbonates (sodium carbonate, potassium carbonate), alkali metal hydrogen carbonates (sodium hydrogen carbonate, potassium hydrogen carbonate), or organic bases such as, for example, triethylamine, ethyl diisopropylamme, tnbutylamine, N-methylmorphohne or pyridine A suitable excess of compound (III) can also be used as a base If compounds (III) are used in form of their acid addition salts, then it is appropriate to consider the amount of auxiliary base used as equivalent The reaction temperatures can - depending on reactivity of the educts - vary in a wide range Generally, the reaction is carried out at temperatures between -40°C and 180°C, preferably between -10°C and 130°C, especially at the boiling point of the solvent used The starting compounds (II) and (III) are known and/or can be produced according to known methods in an analogous manner Moreover, the production of representative examples is further described below Compounds of formula (I) can be (b) produced by reaction of compounds of formula (I), wherein G is hydrogen, and which themselves also have the activities found according to the invention, with a compound of formula (IV), (IV) in which G has the meaning given above, with the exception of hydrogen, and L represents a suitable nucleofuge or reactive group The type of nucleofuge or reactive group L and the conditions of the reaction are dependent of the nature of group G Compounds of formula (I), in which G, with the exception of hydrogen, has the meaning of (Gl) according to the above definition can, aside from method (a), also be (c) produced by reacting compounds of formula (I), in which G is hydrogen, with a suitable alkylation agent and/or arylation agent of formula (IV), wherein G is an alkyl-, alkenyl-, alkinyl-, cycloalkyl-, aryl-, aralkyl-, heteroaryl- or heteroaralkyl residue and the leaving group L can represent a reactive derivative of an alkohol, for example, a halogen atom such as chlorine, bromine or iodine or a sulfonic acid ester, 1 e for example a methanesulfonyloxy-, tπfluoromethanesulfonyloxy-, ethanesulfonyloxy-, benzenesulfonyloxy-, p-toluenesulfonyloxy-, p-bromobenzenesulfonyloxy- or m-nitro- benzenesulfonyloxy residue, etc or a reactive group L can also be an epoxide group, wherein the reaction occurs under addition The reaction of compounds (I), in which G is a hydrogen, and (IV) is usually conducted in a suitably inert solvent As solvents of this type, aromatic hydrocarbons (benzene, toluene, xylene), ethers (for example tetrahydrofuran, dioxane, glycol dimethyl ether), ethyl acetate, acetomtπle, ketones (acetone, ethyl methyl ketone), polar protic solvents such as alcohols (ethanol, isopropanol, butanol, glycol monomethyl ether) or polar aprotic solvents such as, for example, dimethylsulfoxide, dimethylformamide or N-methylpyrrohdone can be considered Pure solvents as well as mixtures of two or more can also be used Preferably, the reactions are carried out in the presence of bases, whereby said bases can be used as in method (a) above If chlorides or bromides are used as compound (IV), the reaction can be accelerated by the addition of alkali metal iodides (sodium iodide, potassium iodide) The reaction temperatures can vary between 0°C and 180°C depending on the reactivity of the educts, but preferably he between 20°C and 130°C Compounds of formula (I), in which G represents an acyl residue, a carbamoyl residue, a sulfonyl residue or a phosphinoyl residue according to the above definition, can also be produced, aside from the above method (a), (d) by reacting compounds of formula (I), wherein G is hydrogen, with a carboxylic acid, carbamic acid, sulfonic acid and/or phosphinic acid of formula (V), H °— G (V) wherein G is an acyl residue, carbamoyl residue, sulfonyl residue or phosphinoyl residue according to definition, or their derivatives capable of reaction Preferred derivatives of carboxylic acids and/or sulfonic acids (V) which are capable of reaction are symmetric or unsymmetπc carboxylic acid anhydrides and/or sulfonic acid anhydrides or acyl- and/or sulfonyl halides, especially acyl- and/or sulfonyl chlorides Preferably, derivatives of carbamates and/or phosphinic acids which are capable of reaction are the carbamoyl halides and/or phosphinyl halides, especially carbamyl- and/or phosphinyl chlorides The reaction of the acids (V) and/or their reactive derivatives with compounds (I), in which G is hydrogen, preferably occurs in the presence of auxiliary bases in solvents and under conditions as they are described in method (a) Compounds of formula (I), wherein G represents a carbamoyl residue according to the definition (G2b) with the proviso that r = 0, the grouping is -C-NR 13 R 15 O can also be produced, aside from the methods (a) and (d) (e) by reacting compounds of formula (I), in which G is hydrogen with a carbonyl group transmitter to an intermediate product and subsequently reacting this directly with a primary or secondary amine with the formula (VI) H _ NR 13 R 15 ^ wherein R 3 and R' -> and/or the grouping ™R ° have the meanings according to the above definitions without having to purify or isolate the intermediate product To-tπchloromethyl carbonate (tnphosgene) and carbonyldiimidazol have been proven as particularly reactive carbonyl group transmitters The reaction of compounds of formula (I), wherein G is hydrogen, with tnphosgene and/or carbonyldiimidazol are typically conducted in an absolute, inert solvent in the presence of a tertiary organic amine as an auxiliary base in such a manner that the solution of compounds (I) and the auxiliary base are slowly poured into a solution of an equivalent amount of carbonyl group transmitter Thereby, the reaction requires molar ratios of 1 1 for the reaction of compound (I) and carbonyldiimidazol, and, in contrast, a ratio of 1 0 35 for the use of tnphosgene After complete reaction of the components to the intermediate product, compound (VI) is added in stochiometric amounts or in excess as a solution or a solid and the reaction is typically completed at elevated temperature Suitable inert solvents are, for example hydrocarbons such as hexane, heptane, benzene, toluene, xylene, chlorinated hydrocarbons (for example dichloromethane, chloroform, 1,2- dichloroethane, tπchloroethylene), ethers (for example diethyl ether, tetrahydrofuran, dioxane), esters such as ethyl acetate, butyl acetate, acetonitπle or polar aprodic solvents such as formamide or dimethylformamide Pure solvents as well as mixtures can be used diversely Sometimes it is of advantage to carry out the first partial reaction at low temperature in a low-viscosity, highly-volatile solvent and to remove the solvent after formation of the intermediate and replace it by a higher boiling solvent Amines such as for example triethylamine, ethyl diisopropylamme, tnbutylamine, N- methylmorphohne or pyridine are suitable as auxiliary bases If compounds (I) or (VI) are used as salts, the amount of the auxiliary base is increased accordingly The reaction temperatures can lie in between -40°C and 50°C for the first partial reaction, preferably at 0°C to 30°C, and between 0°C and 150°C for the second partial reaction, preferably at 20°C to 120°C Compounds of formula (I), wherein G represents a carbamoyl residue according to the definition (G2b) with the proviso that r = 0 and RT ^ = hydrogen, the grouping is 13 — C-NHR II 0 can also be produced, aside from methods (a), (d) and (e) (f) by reacting the compounds of formula (I) in which G is hydrogen, with an isocyanate of formula (VII) in which R' 3 has the meaning according to the above definition 13 O=C=N-R (VII) Reaction of the compounds of formula (I), in which G is hydrogen, with the lsocyanates of formula (VII) are conducted thereby in an absolute, inert solvent which can be a hydrocarbon such as pentane, hexane, heptane, benzene, toluene, or xylene, chlorinated hydrocarbons (such as dichloromethane, chloroform, 1,2-dιchloroethane, tnchloroethylene), ethers (for example, diethyl ether, tetrahydrofuran, dioxane), esters such as ethyl acetate, butyl acetate, or polar aprotic solvents such as formamide or dimethylformamide Mixtures of various solvents can also be used Thereby, the reaction temperatures can vary in the region from -20°C to 150°C, but preferably lie at 20°C to 100°C As already mentioned, the compounds of formula (I), wherein G is hydrogen, are themselves compounds with tumor growth inhibiting activity and/or cytostatic and immunosuppressive effectiveness. However, independent of their therapeutic applicability, they also represent useful intermediate compounds for the production of a multitude of other compounds according to the invention corresponding to (c) to (f) They themselves can, in principle, be produced according to method A by reacting a carboxylic acid of formula (II) with amines of formula (III) in which G is hydrogen as described above However, since the compounds of formula (III) with hydrogen as G represent α,ω-dιamιnes, the formation of product mixtures is always to be expected in their reaction with carboxylic acids (II) or their reactive derivatives making a subsequent separation necessary In contrast, compounds of formula (I), in which G is hydrogen, are essentially more advantageously produced from other compounds of formula (I), in which G is a selectively cleavable group under mild conditions, 1 e corresponds to a nitrogen protective group Among the compounds according to formula (I) with tumor growth inhibiting and/or cytostatic or lmmunomodulatory and/or immunosuppressive properties, are compounds in which G represents a 4-methoxybenzyl group, a tπphenylmethyl group, a methoxy- and/or ethoxycarbonyl group, a tert-butoxycarbonyl group, an allyloxycarbonyl group or a trifluoroacetyl group Thus, compounds of formula (I) with benzyl-, diphenylmethyl-, tnphenylmethyl-, or benzyloxycarbonyl groups as G are already catalytically converted at room temperature under mild conditions with elementary hydrogen or by transfer hydration in compounds of formula (I), wherein G is hydrogen Compounds of formula (I) with a 4-methoxybenzyl group are transformed into compounds of formula (I) wherein G is hydrogen by selective oxidation with ammonιum-cer(IV)-nιtrate The cleavage of simple alkoxycarbonyl groups such as the methoxy- or ethoxycarbonyl group as well as the trifluoroacetyl group as G in compounds of formula (I) succeed by alkali hydrolysis under mild conditions without cleaving the A and D linked amide function This is suitably valid for the cleavage of the tπphenylmethyl group and the tert-butoxycarbonyl group as G in compounds of formula (I), which occurs in acidic medium under mild conditions Finally, compounds of formula (I) with an allyloxycarbonyl group as G can be converted into such with hydrogen as G in neutral medium with palladium catalyst The described methods are fully familiar to the person skilled in the art and are furthemore also documented in monographs (see for example Greene, Wuts, Protective Groups in Organic Synthesis, New York, 1991) Compounds of formula (I), wherein R^ is an alkyl, alkenyl, alkinyl or cycloalkyl residue according to the above definition can also be produced, aside from the methods (a) and (b), (g) by reacting compounds of formula (I), wherein R^ is hydrogen, with a suitable alkylation agent of formula (VIII) R 4 (VIII) wherein R^ ts an alkyl, alkenyl, alkinyl or cycloalkyl residue according to the above definition and L is a suitable nucleofuge, i e for example a halogen atom such as chlorine, bromine or iodine or a sulfonic acid ester of an alcohol Preferred sulfonic acid esters (VIII) contain a methylsulfonyloxy residue, tπfluoromethanesulfonyloxy-, p- toluenesulfonyloxy-, p-bromobenzenesulfonyloxy- or m-nitrobenzenesulfonyloxy residue as L As an amide alkylation in the presence of tertiary amino groups, this reaction requires the use of strong auxiliary bases such as potassium-tert-butylate, sodium hydride, potassium hydride or butyl lithium in aprotic, inert solvents Such solvents can be for example aliphatic or aromatic hydrocarbons (pentane, hexane, heptane, benzene, toluene), ethers (for example, tetrahydrofuran, dioxane) or polar solvents such as dimethylsulfoxide, dimethylformamide or N-methylpyrrohdone Depending on the reactivity of the educts, the reaction temperatures can he between -40°C and 140°C preferably between -20°C and 80°C The compounds of formula (I) produced according to the methods (a) to (g) can be isolated and purified in a known manner, for example by subjecting the residue after distillation of the solvent to partition, extraction, re-precipitation or re-crystallization or another purification method For this, column chromatography on a suitable support or preparative, middle or high pressure liquid chromatography are preferred for this The compounds (I) are first normally obtained in form of their free bases or the?'" hydrates or solvates, depending on the type of isolation and purification Their addition salts with pharmaceutically suitable acids are obtained in a * -al manner by converting the base with the desired acid in a suitable solvent > ndιng on the number of basic centers of compound (I), one or more equivalent s per mole of base can be bound Suitable solvents are, for example, chlorinated hydrocarbons such as dichloromethane or chloroform, ethers such as diethyl ether, dioxane or tetrahydrofuran, acetonitπle, ketones such as acetone or ethyl methyl ketone, esters such as methyl acetate or ethyl acetate or low molecular alcohols such as methanol, ethanol or isoj oanol, and water Pure solvents as well as mixtures of two or three solvents can also oe used The salts can be isolated by crystallization, precipitation or the evaporation of the solvent Thereby, they optionally accumulate as hydrates or solvates The bases can be recovered from the salts by alkalization, for example with aqueous ammonia solution, alkali carbonate or diluted sodium hydroxide solution The following listed compounds and/or their pharmaceutically acceptable saltsare particularly preferred N-[4-(l-acetyl-pιperιdιn-4-yl)-butyl]-3-(pyπdιn-3-yl)-propιonamιde, N-[4-(l-benzoyl-pιpeπdιn-4-yl)-butyl]-3-(pyπdιn-3-yl)-propιonamιde, N-[4-(l-dιphenylacetyl-pιpeπdιn-4-yl)-butyl]-3-(pyπdιn-3-yl)-propιonamιde, N-{4-[l-(9-oxo-9H-fluoren-4-carbonyl)-pιpeπdιn-4-yl]-butyl}-3-(pyπdιn-3-yl)- propionamide, N-[4-(l-methylsulfonyl-pιpeπdιn-4-yl)-butyl]-3-(pyπdιn-3-yl)-propιonamιde, N-{4-[l-(2-naphthyl-suIfonyl)-pιpeπdιn-4-yl]-butyl}-3-(pyπdιn-3-yl)-propιonamιde, N-[4-(l -benzyl-pιpeπdιn-4-yl)-butyl]-3-(pyπdιn-3-yl)-propιonamιde, N-(4-{ l-[bιs-(2-chlorophenyl)-methyl]-pιpeπdιn-4-yl}-butyl)-3-(pyπdιn-3-yl)- propionamide, N-{4-[l -(phenyl-pyrιdιn-3-yl-methyl)-pιpeπdιn-4-yl]-butyl}-3-(pyπdιn-3-yl)- propionamide, N-{4-[l-(9H-fluoren-9-yl)-pιpeπdιn-4-yl]-butyl}-3-(pyπdιn-3-yl)-propιonamιde, N-{4-[l -(6,l l-dιhydrodιbenzo[b > e]oxepm-l l-yl)-pιpeπdιn-4-yl]-butyl}-3-(pyπdιn-3- yl)-propιonamιde, N-{4-[l -(l -naphthylamιnocarbonyl)-pιpeπdιn-4-yl]-butyl}-3-(pyπdιn-3-yl)- propionamide, N-[4-(l -dιphenylamιnocarbonyl-pιpeπdιn-4-yl)-butyl]-3-(pyπdιn-3-yl)-propιonamιde, N-{4-[ 1 -( 10, 1 1 -dιhydrodιbenzo[b,f]azepιn-5-yl-carbonyl)-pιpeπdιn-4-yl]-butyl } -3- (pyπdιn-3-yl)-propιonamιde, N-[4-(l -dιphenylphosphιnoyl-pιpeπdιn-4-yl)-butyl]-3-(pyπdιn-3-yl)-propιonamιde, N-[4-(l -dιphenylmethyl-pιpeπdιn-4-yl)-butyl]-3-(2-fluorpyπdιn-3-yl)-propιonamιde, N-[4-(l-dιphenylmethyl-pιpeπdιn-4-yl)-butyl]-3-(5-fluorpyπdιn-3-yI)-propιonamιde, N-[4-(l -dιphenylmethyl-pιperιdιn-4-yl)-butyl]-2-fluor-3-(pyπdιn-3-yl)-propιonamιde, N-[4-(l-dιphenylmethyl-pιpeπdιn-4-yl)-butyl]-2,2-dιfluor-3-(pyπdιn-3-yl)- propionamide, N-[5-(l-dιphenylmethyl-pιpeπdιn-4-yl)-pentyl]-3-(pyπdιn-3-yl)-propιonamιde, N-[6-(l -dιphenylmethyl-pιperιdιn-4-yl)-hexyl]-3-(pyndιn-3-yl)-propιonamιde, N-[2-(l -dιphenylmethyl-pιpeπdιn-4-yl)-ethyl]-5-(pyπdιn-3-yl)-pentanoιc acid amide, N-[4-(l-dιphenylmethyl-pιpendιn-4-yl)-butyl]-5-(pyπdιn-3-yl)-pentanoιc acid amide, N-[4-(l -dιphenylmethyl-pιpeπdιn-4-yl)-butyl]-N-hydroxy-3-(pyπdιn-3-yl)- propionamide, N-[4-(l-diphenylmethyl-piperidin-4-yl)-butyl]-2-hydroxy-3-(pyridin-3-yl)- propionamide, N-[4-(l -diphenylmethyl-piperidin-4-yl)-butyl]-3-hydroxy-3-(pyridin-3-yl)- propionamide and N-[4-(l-diphenylmethyl-piperidin-4-yl)-butyl]-3-(pyridin-3-yl)-propionamide. SYNTHETIC EXAMPLES for the end products of the invention according to formula (I) In the following production examples for the end products, the abbreviations stand for the following terms: MP = melting point, RT = room temperature, THF = tetrahydrofuran, DMF = dimethylformamide, CDI = carbonyldiimidazol, EDC = N-(3-dimethylaminopropyl)-N'-ethyl-carbodiimide hydrochloride, HOBT= 1-hydroxybenzotriazol, TEA = triethylamine. Η-NMR-Spectrum = proton resonance spectrum, taken at 100 MHz. The chemical shifts are given in ppm against TMS as a standard (δ = 0.0), whereby Example 1 N-[4-(l-diphenylmethyI-piperidin-4-yl)-butyl]-2-(pyridin-3-yloxy)-acetamide (substance 84) 5 0 g (32 6 mmol) 3-pyπdyloxy acetic acid and 3 95 g (39 1 mmol) TEA are suspended in 200 ml absolute dichloromethane and cooled to ca 0°C under moisture exclusion 6 34 g (41 3 mmol) 88% HOBT and 7 49 g (39 1 mmol) EDC are added and the mixture is stirred for 30 min under ice cooling 1 1 56 g (35 9 mmol) N-4-(l -dιphenyl- methyl-pιpeπdιn-4-yl)-butylamιne are dissolved in 50 ml absolute dichloromethane and added dropwise under ice cooling The mixture is stirred at RT overnight without further cooling Subsequently, the batch is washed once with 50 ml 1 M NaOH and twice, each with 70 ml water The organic phase is dried over sodium sulfate and the solvent is removed under vacuum The resinous residue is chromatographically purified over silica gel with CHCl 3 /CH 3 OH (95/5 to 90/10) and crystallized from 30 ml acetic acid ethyl ester after drawing off the solvent Colorless crystals with an MP of 103-105°C, yield 3 45 g (23%) IR-spectrum (KBr) v(NH) 3360 cm '1 v(C=O) 1660 1540 cm '1 Η-NMR-spectrum (CDC1 3 ) 0 95 - 2 05 (13H, m, piperidine, pιpeπdιne-(CH 2 ) 3 ) 2 70 - 3 00 (2H, m, piperidine) 3 34 (2H, dt, CONHCH2, J=6 5 Hz, J=12 9 Hz) 4 21 (IH, s, Ar 2 CH) 4 51 (2H, s, COCH 2 O) 6.40 - 6.70 (IH, m, NH) 7.00 - 7.60 (12H, m, ar, py) 8.20 - 8.45 (2H, m, py) Example 2 N-[4-(l-diphenylmethyl-piperidin-3-yl-carbonylamino)-bιιtyIJ-3-(pyridin-3-yl)- propionamide (substance 106) Production occurs analogously to example 1. Batch size: 2.06 g (13.6 mmol) 3-(3-pyridyl)-propionic acid, 4.40 g (43.5 mmol) TEA, 2.40 g (14.1 mmol) 88% HOBT, 3.12 g (16.3 mmol) EDC and 5.48 g (15.0 mmol) 1 - diphenylmethyl-piperidin-3-yl-carboxylic acid-(4-amino-butyl)-amide. In the purification, this is chromatographed at first with CHCl 3 /CH 3 OH (95/5) and subsequently crystallized from 60 ml acetonitrile. Colorless crystals with an MP of 159-161 °C; yield 3.2 g (47%). C 3I H 38 N 4 O 2 (498.7) IR-spectrum (KBr): v(NH) 3310 cm " v(O0) 1640, 1560 cm " Η-NMR-spectrum (CDC1 3 ): 1.20 - 2.30 (1 1 H, m, piperidine, C-(CH 2 ) 2 -C) 2.48 (2H, t, CO-CH 2 , J=7.5 Hz) 2.60 - 2.90 (2H, m, piperidine) 2.98 (2H, t, py-CH 2 , J=7.5 Hz) 3 10 - 3 50 (4H, m, CONHCHj) 4 25 (1 H, s, Ar 2 CH) 6 15 - 6 40 (lH, m, NH) 7 10 - 7 65 (12H, m, ar, py) 7 75 - 8 10 (lH, m, NH) 8 35 - 8 55 (2H, m, py) Example 3 N-[5-(l-diphenylmethyl-piperidin-4-yl)-pentyI]-3-(pyridin-3-yl)-propionamide (substance 101) 2 47 g (16 3 mmol) 3-(3-pyπdyl)-propιonιc acid are suspended in 40 ml absolute dichlormethane and cooled to ca 0°C in an ice bath under moisture exclusion after addition of three drops pyridine 1 90 ml (22 3 mmol) oxalyl chloride are slowly added, and the mixture is first stirred for 30 min under ice cooling and then at RT overnight Subsequently, the solvent and excess oxalyl chloride are distilled on a rotary evaporator In order to completely remove the oxalyl chloride, the colorless residue is dried for two hours under high-vacuum The acid chloride obtained in this manner is suspended in 50 ml absolute dichloromethane without further purification and cooled to ca 0°C in an ice bath under moisture exclusion 5 0 g (14 8 mmol) 5-(l - dιphenylmethyl-pιpeπdιn-4-yl)-pentylamιne are dissolved in 40 ml absolute dichloromethane and added dropwise to this suspension After complete addition, the ice bath is removed, and the reaction is stirred for two hours at RT The mixture is subsequently concentrated, taken up in 10% sodium hydroxide solution and extracted three times with acetic acid ethyl ester The combined organic phases are washed with saturated NaCl-solution, dried over sodium sulfate and the solvent is removed under vacuum The residue is chromatographically purified over silica gel with CHCl 3 /CH 3 OH (96/4) and crystallized from 40 ml acetonitrile after drawing off the solvent Colorless crystals with an MP of 1 12-1 14°C, yield 3 5 g (50%) C 3 ,H 39 N O (469 7) IR-spectrum (KBr) v(NH) 3260 cm ' v(C=O) 1635, 1550 cm Η-NMR-spectrum (CDC1 3 ) 0 90 - 2 00 (15H, m, piperidine, pιpeπdιne-(CH 2 ) 4 ) 2 44 (2H, t, CO-CH 2 , J=7 5 Hz) 2 70 - 3 10 (4H, m, piperidine, py-CH 2 ) 3 19 (2H, dt, CONHCH 2 J=6 6 Hz, J=12 6 Hz) 4 21 (IH, s, Ar 2 CH) 5 30 - 5 60 (IH, m, NH) 7 00 - 7 75 (12H, m, ar, py) 8 35 - 8 65 (2H, m, py) Example 4 N-[4-(l-diphenylmethyl-piperidin-4-yl)-butyl]-3-(pyridin-3-yl)-propionamide (substance 54) 21 6 g (131 mmol) 3-(3-pyπdyl)-propιonιc acid methyl ester, 35 1 g (109 mmol) 4-(l- dιphenylmethyl-pιpeπdιn-4-yl)-butylamme and 9 8 g (54 5 mmol) 30% sodium methylate solution in methanol are heated to boiling in 480 ml toluene for five hours Subsequently, 30 ml of solvent is distilled off, sodium methylate precipitates thereby, and the temperature of the suspension increases under heavy foaming to 102°C The mixture is cooled to 70-80°C and extracted twice with 45 ml and 30 ml water The organic phase is azeotropically dried in a moisture separator and cooled to ca 0°C The resulting precipitate is filtered and crystallized from 190 ml toluene. Colorless crystals with an MP of 139°C; yield 46.3 g (93%). C 30 H 37 N 3 O (455.6) IR-spectrum (KBr): v(NH) 3250 cm "1 v(C=0) 1630, 1570 cm '1 Η-NMR-spectrum (CDC1 3 )- 1.00 - 2.10 (13H, m, piperidine, piperidine-(CH 2 ) 3 ) 2.43 (2H, t, CO-CH 2 , J=7.4 Hz) 2.70 - 3.10 (4H, m, piperidine, py-CH 2 ) 3.12 (2H, dt, CONHCHa, J=6.5 Hz, J=12.5 Hz) 4.21 (IH, s, Ar 2 CH) 5.45 - 5.75 (lH, m, NH) 7.05 - 7.60 (12H, m, ar, py) 8.30 - 8.60 (2H, m, py) Example 5 N-{4-[l-(6,ll-dihydrodibenzo[b,e]oxepin-l l-yl)-piperidin-4-yl]-butyl}-3-(pyridin- 3-yl)-propionamide (substance 142) 3.46 g (15 mmol) 1 l-chloro-6,1 l-dihydrodibenzo[b,e]oxepine are dissolved in 90 ml absolute dichloromethane and 5.43 g (15 mmol) N-(4-piperidin-4-yl-butyl)-3-pyridin- 3-yl-propionamide dihydrochloride is added. 5.0 g (49.5 mmol) TEA is dissolved in 20 ml absolute dichloromethane and added dropwise under ice cooling. The mixture is stirred for two days at RT without further cooling. Subsequently, the batch is washed twice, each with 50 ml water. The organic phase is dried over sodium sulfate and the solvent is removed under vacuum. The resinous residue is chromatographically purified over silica gel with CHCl 3 /CH 3 OH (95/5) and after drawing off the solvent, is first crystallized twice, each from 10 ml 1 -chlorobutane and subsequently once from 10 ml acetic acid ethyl ester Colorless crystals with a MP of 1 10-1 12°C in a yield of 0 2 g (3%) are recovered C 31 H 37 N 3 O 2 (483.6) IR-spectrum (KBr): v(NH) 3240 cm " v(C=O) 1630, 1570 cm " Η-NMR-spectrum (CDC1 3 ) 0.80 - 2.00 (13H, m, piperidine, piperidιne-(CH 2 ) 3 ) 2 43 (2H, t, CO-CH 2 , J=7 5 Hz) 2.55 - 3 30 (6H, m, piperidine, py-CH 2 , CONHCHj) 3.83 (IH, s, Ar 2 CH) 4.68 (lH, d, O-CH, J=l l 3 Hz) 5.25 - 5.55 (lH, m, NH) 6 65 - 7.65 (1 IH, m, ar, py, O-CH) 8.35 - 8 60 (2H, m, py) Example 6 N-[4-(l-diphenylphosphinyl-piperidin-4-yl)-butyl]-3-(pyridin-3-yl)-propionamide (substance 223) 3 4 ml (17.3 mmol) diphenylphosphinic acid chloride are dissolved in 100 ml absolute THF and cooled to ca 0°C under moisture exclusion. 5 0 g (17 3 mmol) N-(4- pιpeπdιn-4-yl-butyl)-3-(pyπdιn-3-yl)-propιonamιde and 4.8 ml (34.6 mmol) TEA are dissolved in 50 ml absolute THF and added dropwise under ice cooling The mixture is stirred for three days at RT without further cooling Subsequently, the solvent is removed under vacuum to a large extent and the residue is taken up in 100 ml 10% sodium hydroxide solution and extracted twice, each with 150 ml CHC1 3 The combined organic phases are washed with saturated NaCl-solution, dried over sodium sulfate and the solvent is removed under vacuum The residue is chromatographically purified over silica gel with CHCl 3 /CH 3 OH (90/10) and crystallized from dnsopropyl ether after drawing off the solvent Colorless crystals with an MP of 134-135°C, yield 5 3 g (62%) C 29 H 36 N 3 0 2 P (489 6) IR-spectrum (KBr) v(NH) 3240 cm " v(C=O) 1660, 1550 cm Η-NMR-spectrum (CDC1 3 ) 0 90 - 1 90 (1 IH, m, piperidine, pιpeπdme-(CH 2 ) 3 ) 2 30 - 3 60 (10H, m, piperidine, py-CH 2 -CH 2 , CONHCH 2 ) 6 35 - 6 70 (l H, m, NH) 7 00 - 8 15 (12H, m, ar, py) 8 25 - 8 70 (2H, m, py) Example 7 N-[4-(l-diphenylmethyl-piperidin-4-yl)-butyl]-5-(pyridin-3-yl)-pentanoic acid amide (substance 90) Production occurs analogously to example 3 Batch size: 5.0 g (27 9 mmol) 5-(pyridin-3-yl)-pentanoιc acid, 6 7 ml (76 1 mmol) oxalyl chloride and 8.2 g (25 3 mmol) 4-(l -diphenylmethyl-pipendιn-4-yl)-butylamιne During purification extraction is done three times, each with 100 ml CHC1 3 instead of acetic acid ethyl ester The combined organic phases are washed twice, each with 50 ml saturated NaCl-solution. After chromatographic purification with CHCl 3 /CH OH (95/5), this is crystallized from 70 ml acetic acid ethyl ester Colorless crystals with an MP of 109°C, yield 4.0 g (29%) C 32 H 41 N 3 O (483.7) IR-spectrum (KBr) v(NH) 3280 cm ' v(C=O) 1630, 1545 cm " Η-NMR-spectrum (CDC1 3 ) 1.00 - 2 00 (17H, m, piperidine, pιpeπdine-(CH 2 ) 3 , C-CH 2 -CH 2 -C) 2.00 - 2.35 (2H, m, CO-CH 2 ) 2.50 - 2.75 (2H, m, py-CH 2 ) 2.75 - 3 00 (2H, m, piperidine) 3 21 (2H, dt, CONHCi, J=6 3 Hz, J=12.2 Hz) 4.21 (IH, s, Ar 2 CH) 5 35 - 5.70 (lH, m, NH) 7 00 - 7 60 (12H, m, ar, py) 8 30 - 8.50 (2H, m, py) Example 8 N-{4-[l-(9H-fluoren-9-yl)-piperidin-4-yl]-butyl}-3-(pyridin-3-yI)-propionamide (substance 133) 8 0 g (27 7 mmol) N-(4-pιpeπdιn-4-yl-butyl)-3-(pyπdιn-3-yl)-propιonamιde and 5 6 g (55 3 mmol) TEA are placed in 100 ml acetonitrile and cooled to ca 0°C under moisture exclusion 6 8 g (27 7 mmol) 9-bromofluorene are added in solid form and the mixture is stirred two days at ca 65°C and two days at RT Subsequently, the solvent is drawn off under vacuum to a large extent, and the residue is dispersed between CHC1 3 and 10% NaOH The organic phase is washed twice with water and dried over sodium sulfate After the removal of the solvent, the residue is chromatographically purified over silica gel with CHCl 3 /CH 3 OH (98/2 to 94/6) and crystallized from 30 ml acetonitrile after drawing off the solvent Colorless crystals with an MP of 131 -132°C, yield 2 5 g (20%) C 30 H 35 N 3 O (453 6) IR-spectrum (KBr) v(NH) 3300 cm " ' v(C=0) 1630, 1530 cm "1 Η-NMR-spectrum (CDC1 3 ) 0 95 - 1 80 (1 IH, m, piperidine, pιpendιne-(CH 2 ) 3 ) 2 25 - 2 80 (6H, m, piperidine, CO-CH 2 ) 2 97 (2H, t, py-CH 2 , J=7 5 Hz) 3 19 (2H, dt, CONHCH 2 , J=6 5 Hz, J=12 5 Hz) 4 82 (1H, s, ArCH) 5 25 - 5 55 (IH, m, NH) 7 10 - 7 80 (10H, m, ar, py) 8 35 - 8 55 (2H, m, py) Example 9 N-{4-(l-(2-naphthylsulfonyl)-piperidin-4-yl]-butyl}-3-(pyridin-3-yl)-propionamide (substance 212) 3 5 g (12 mmol) N-(4-pιpeπdιn-4-yl-butyl)-3-(pyπdιn-3-yl)-propιonamιde and 6 7 ml (48 1 mmol) TEA are placed in 100 ml absolute dichloromethane and cooled to ca 0°C under moisture exclusion 3 0 g (13 2 mmol) naphthahn-2-sulfonιc acid chloride are dissolved in 40 ml absolute dichloromethane and added dropwise The mixture is stirred without further cooling at RT overnight Subsequently, the batch is washed twice, each with 80 ml water The organic phase is dried over sodium sulfate and the solvent is removed under vacuum The residue is chromatographically purified over silica gel with CHCI 3 /CH 3 OH (97/3) and crystallized from acetic acid ethyl ester after drawing off the solvent Colorless crystals with an MP of 103-105°C, yield 2 87 g (50%) C 27 H 33 N 3 O 3 S (479 6) IR-spectrum (KBr) v(NH) 3320 cm " v(C=O) 1645, 1530 cm Η-NMR-spectrum (CDC1 3 ) 0 90 - 1 90 (1 IH, m, piperidine, pιpeπdιne-(CH 2 ) 3 ) 2 05 - 2 40 (2H, m, piperidine) 2 42 (2H, t, CO-CH 2 , 5=1 4 Hz) 2.80 - 3 30 (4H, t, dt, py-CH 2 , J-7 4 Hz, CONHC b) 3 70 - 4 00 (2H, m, piperidine) 5.40 - 5.70 (lH, m, NH) 7.10 - 8.15 (8H, m, ar, py) 8.25 - 8.55 (3H, m, ar, py) Example 10 N-[4-(l-benzoylpiperidin-4-yl)-butyl]-3-(pyridin-3-yl)-propionamide (substance 162) 3 48 ml (30 mmol) benzoyl chloride, 8.7 g (30 mmol) N-(4-pιpeπdιn-4-yl-butyl)-3- (pyπdιn-3-yl)-propionamide and 16.6 g (120 mmol) potassium carbonate are stirred in 160 ml DMF at RT overnight Subsequently, this is filtered and the filtrate is concentrated under vacuum to a large extent. The residue is taken up in 400 ml CHC1 3 and washed twice, each with 100 ml water The organic phase is dried over sodium sulfate and the solvent is removed under vacuum The residue is chromatographically purified over silica gel with CHCl 3 /CH 3 OH (95/5) and precipitates as an amorphous solid after drawing off the solvent C 24 H 31 N 3 O 2 (393.5) IR-spectrum (KBr) v(NH) 3250 cm - " 1 v(C=O) 1630, 1550 cm "1 Η-NMR-spectrum (CDCI3) 0 85 - 1.95 (1 IH, m, piperidine, pιperidine-(CH 2 ) 3 ) 2.44 (2H, t, CO-CH 2 , J=7 4 Hz) 2 50 - 3 35 (6H, m, piperidine, py-CH 2 , CONHCϋ) 3 50 - 4 00 (IH, m, piperidine) 4 40 - 4 90 (IH, m, piperidine) 5 70 - 6 05 (IH, m, NH) 7 10 - 7 65 (7H, m, ar, py) 8 35 - 8 55 (2H, m, py) Example 11 N-{4-[l-(l-naphthylaminocarbonyl)-piperidin-4-yl]-butyl}-3-(pyridin-3-yl)- propiona ide (substance 194) 2 6 ml (17 7 mmol) 1 -naphthyl isocyanate are dissolved in 15 ml absolute THF and cooled to ca 0°C under moisture exclusion 5 1 g (17 7 mmol) N-(4-pιpeπdιn-4-yl- butyl)-3-(pyπdιn-3-yl)-propιonamιde are dissolved in 35 ml absolute THF and added dropwise under ice cooling The mixture is stirred at RT overnight without further cooling Subsequently, the solvent is drawn off under vacuum to a large extent and the residue is chromatographically pre-punfied over silica gel with CHCl 3 /CH 3 OH (90/10) and further purified by flash-chromatography with CHCl 3 /CH 3 OH (95/5 to 90/10) After drawing off the solvent, this is crystallized from isopropanol/dusopropyl ether Colorless crystals with an MP of 143-144°C, yield 0 77 g (9%) C 28 H 34 N 4 0 2 (458 6) IR-spectrum (KBr) v(NH) 3240 cm '1 v(CO) 1630, 1560 cm "1 Η-NMR-spectrum (CDC1 3 ) 0 95 - 1 95 (1 IH, m, piperidine, pιpeπdιne-(CH 2 ) 3 ) 2 40 (2H, t, CO-CH 2 , J=7 4 Hz) 2 75 - 3 40 (6H, m, piperidine, py-CH 2 , CONHCHj) 4.00 - 4 30 (2H, m, piperidine) 5 55 - 5 85 (lH, m, NH) 6 77 (lH, s, NH) 7 10 - 8 00 (9H, m, ar, py) 8 35 - 8 55 (2H, m, py) Example 12 N-{4-[l-(cyclohexylphenylmethyl)-piperidin-4-yl]-butyl}-3-(pyridin-3-yl)- propionamide (substance 46) 3 8 g (15 0 mmol) (bromocyclohexylphenyl)-methane, 4 3 g (15 0 mmol) N-(4- pιpeπdιn-4-yl-butyl)-3-(pyπdιn-3-yl)-propιonamιde, 3 1 g (22 5 mmol) potassium carbonate and 0 22 g (1 5 mmol) sodium iodide are stirred in 40 ml DMF for two hours at ca 105°C After cooling, the mixture is poured into 100 ml water and extracted with 150 ml acetic acid ethyl ester The organic phase is dried over sodium sulfate and the solvent is removed under vacuum The residue is chromatographically purified twice over sihca gel with CHCl 3 /CH 3 OH (90/10 and 95/5) and crystallized from 10 ml acetonitrile after drawing off the solvent. Beige colored crystals with an MP of 109- 1 10°C, yield 1 4 g (20%) IR-spectrum (KBr) v(NH) 3290 cm " v(C=O) 1635, 1545 cm ' 1H-NMR-spectrum (CDC1 3 ) 0 50 - 2 20 (24H, m, piperidine, pιpeπdιne-(CH 2 ) 3) cyclohexane) 2 43 (2H, t, CO-CH 2 , J=7 4 Hz) 2 50 - 3 40 (7H, m, piperidine, py-CH2, CONHCHj, ar-CH) 5 40 - 5 80 (IH, m, NH) 6 90 - 7 70 (7H, m, ar, py) 8 30 - 8 60 (2H, m, py) Example 13 N-[2-(l-diphenylmethyl-piperidin-4-ylamino)-ethyl]-3-(pyridin-3-yl)- propionamide trihydrochloride semiisopropanolate (substance 52 as a hydrochloride) Production occurs analogously to example 1 Batch size 1 8 g (1 1 7 mmol) 3-(3-pyπdyl)-propιonιc acid, 1 6 ml (1 1 7 mmol) TEA, 2 4 g (14 4 mmol) 81% HOBT, 2 7 g (14 1 mmol) EDC and 4 0 g (12 9 mmol) N-l-(l- dιphenylmethyl-pιpeπdιn-4-yl)-ethan-l,2-dιamιne in 100 ml absolute dichloromethane In the purification, this is first chromatographically pre-punfied with CHCyCHsOH/NH t OH (90/9/1) and flash-chromatography is subsequently carried out with CHCU/CH 3 OH (90/10) After removing the solvent, the residue is dissolved in 50 ml isopropanol and added to 4 1 ml ca 4 M lsopropanohc hydrochloric acid The salt precipitated in the cold is drawn off and dried Yield of yellow foam 1 1 g (17%) C 8 H 34 N 4 0 • 3 HCI • 1/2 isopropanol (582.0) IR-spectrum (KBr): v(NH) 3400 cm -1 v(C=O) 1650, 1540 cm -1 Η-NMR-spectrum (D 2 0): 1.70 - 2.35 (4H, m, piperidine) 2.54 (2H, t, CO-CH 2 , J=7.2 Hz) 2.80 - 3.60 (1 IH, m, piperidine, py-CH 2 , NH-C b, CONHCHz) 5.23 (IH, s, Ar 2 CH) 7.20 - 7.60 (1 OH, m, ar) 7.70 - 7.90 (lH, m, py) 8.20 - 8.55 (3H, m, py) Example 14 N-[3-(l-benzyIpiperidin-4-yloxy)-propyl]-3-(pyridin-3-yl)-propionamide (substance 36) Production occurs analogously to example 3. Batch size: 2.2 g (14.6 mmol) 3-(3-pyridyl)-propionic acid, 3.8 ml (43.9 mmol) oxalyl chloride and 4.0 g (16.1 mmol) 3-(l-benzylpiperidin-4-yloxy)-propylamine in 50 ml absolute dichloromethane. In the purification, this is chromatographically purified twice over silica gel with CHCyCftOH/NHiOH (90/10/0 to 90/10/1) and CHCl 3 /CH 3 OH (95/5 to 90/10) and crystallized from 10 ml 1 -chlorobutane after drawing off the solvent. Orange-yellow colored crystals with an MP of 55-57°C; yield 1.8 g (32%). C 23 H 3 ,N 3 O 2 (381.5) IR-spectrum (KBr): v(NH) 3305 cm " v(C=O) 1630, 1530 cm " Η-NMR-spectrum (CDC1 3 ): 1.35 - 2.35 (8H, m, piperidine, C-(CH 2 )-C) 2.43 (2H, t, CO-CH 2 , J=7.4 Hz) 2.60 - 2.90 (2H, m, piperidine) 2.97 (2H, t, py-CH 2 , J=7.4 Hz) 3.10 - 3.60 (7H, m, piperidine, CONHCHz, O-CH 2 , ar-CH 2 ) 6.10 - 6.55 (lH, m, NH) 7.10 - 7.40 (6H, m, ar, py) 7.40 - 7.65 (IH, m, py) 8.35 - 8.55 (2H, m, py) Example 15 N-(4-{l-[bis-(2-chIorophenyl)-methyI]-piperidin-4-yl}-butyl)-3-(pyridin-3-yI)- propionamide (substance 118) Production occurs analogously to example 12. Batch size: 4.0 g (12.7 mmol) bis-(2-chlorophenyl)-bromomethane, 3.7 g (12.7 mmol) N-(4-piperidin-4-yl-butyl)-3-(pyridin-3-yl)-propionamide, 2.6 g (19.0 mmol) potassium carbonate and 0.2 g (1.3 mmol) sodium iodide in 40 ml DMF. The reaction temperature and time are 85°C and 1 1 hours In the purification, this is chromatographically purified twice over silica gel with CHC1 3 /CH 3 0H (95/5 to 90/10 and 95/5) and crystallized three times from 10 ml acetonitrile, from 10 ml 1 -chlorobutane and subsequently from 6 ml lsopropanol/di- lsopropyl ether (5/1) after drawing off the solvent Colorless crystals with an MP of 125°C, yield 1 6 g (24%) C 30 H 35 Cl 2 N 3 O (524 5) IR-spectrum (KBr) v(NH) 3240 cm " v(C=O) 1625, 1545 cm " Η-NMR-spectrum (CDC1 3 ) 0 90 - 1 85 (1 IH, m, piperidine, pιpeπdιne-(CH 2 ) 3 ) 1 90 - 2 30 (2H, m, piperidine) 2 44 (2H, t, CO-CH 2 , J=7 5 Hz) 2 55 - 2 85 (2H, m, piperidine) 2 97 (2H, t, py-CH 2 , J=7 5 Hz) 3 19 (2H, dt, CONHCHj, J=6 5 Hz, J=12 4 Hz) 5 31 (IH, s, Ar 2 CH) 5 35 - 5 60 (lH, m, NH) 6 95 - 7 70 (10H, m, ar, py) 8 30 - 8 55 (2H, m, py) Example 16 N-[4-(l-diphenylmethyl-piperidin-4-yl)-butyI]-N-ethyl-3-(pyridin-3-yl)- propionamide (substance 68) 0 79 g (26.3 mmol) 80%) sodium hydride are suspended in 30 ml DMF and 10.0 g (22.0 mmol) N-[4-(l-diphenylmethyl-pιperidin-4-yl)-butyl]-3-(pyπdιn-3-yl)- propionamide (substance 54) are added. The mixture is warmed to ca 30°C and, after addition of 0.2 g tetrabutyl ammonium iodide, this is stirred for one hour Subsequently, 2.0 ml (24.1 mmol) ethyl iodide is added at RT (foam development) and the orange-brown suspension is stirred at RT overnight. Excess sodium hydride is destroyed by addition of 1 ml water and the mixture is concentrated under vacuum to a large extent. The residue is dispersed between 50 ml water and 100 ml dichloromethane. The organic phase is dried over sodium sulfate and the solvent is removed under vacuum. The residue is chromatographically purified three times over silica gel with CHCl 3 /CH 3 OH (97/3 and 100/0 to 97/3 and 98/2) and crystallized from 10 ml 1 -chlorobutane/petroleum ether (3/7) after drawing off the solvent Beige colored crystals with an MP of 72-74°C; yield 3.6 g (34%). C 32 H 41 N 3 O (483.7) IR-spectrum (KBr): v(C=O) 1630 cm H-NMR- spectrum (CDC1 3 ): 0.90 - 2.00 (16H, m, piperidine, pιperidine-(CH 2 ) 3 , CH 3 ) 2.40 - 3.50 (1 OH, m, CO-CH 2 , N-CH 2 , py-CH 2 , piperidine) 4.21 (IH, s, Ar 2 CH) 6.95 - 7.70 (12H, m, ar, py) 8.35 - 8.60 (2H, m, py) Example 17 N-{4-[l-(biphenyl-4-carbonyl)-piperidin-4-yl]-butyl}-3-(pyridin-3-yl)- propionamide (substance 168) Production occurs analogously to example 10 Batch size 5 0 g (23 1 mmol) bιphenyl-4-carboxylιc acid chloride, 6 7 g (23 1 mmol) N-(4-pιpeπdιn-4-yl-butyl)-3-(pyπdιn-3-yl)-propιonamιde and 12 8 g (92 3 mmol) potassium carbonate in 120 ml DMF In the work up, this is dispersed between 300 ml CHC1 3 and 75 ml water In the purification, this is first chromatographed over silica gel with CHCI3/CH3OH (95/5) and subsequently crystallized from 1 -chlorobutane Colorless crystals with an MP of 104-105°C, yield 6 1 g (56%) IR-spectrum (KBr) v(NH) 3310 cm " ' v(C=O) 1625, 1530 cm "1 Η-NMR-spectrum (CDCI3) 0 95 - 2 10 (1 IH, m, piperidine, pιpeπdme-(CH )3) 2 56 (2H, t, CO-CH2, J=7 4 Hz) 2 65 - 3 50 (6H, m, piperidine, py-CH 2 , CONHCHj) 3 65 - 4 20 (IH, m, piperidine) 4 50 - 5 00 (IH, m, piperidine) 5 70 - 6 05 (lH, m, NH) 7 10 - 7 90 (l lH, m, ar, py) 8 40 - 8 70 (2H, m, py) Example 18 N-{4-[l-(2-naphthoyl)-piperidin-4-yl]-butyl}-3-(pyridin-3-yl)-propionamide (substance 175) 6 0 g (20 7 mmol) N-(4-pιpeπdιn-4-yl-butyl)-3-(pyπdιn-3-yl)-propιonamιde and 2 1 g (20 7 mmol) TEA are dissolved in 30 ml absolute dichloromethane and cooled to ca 0°C under moisture exclusion 3 95 g (20 7 mmol) 2-naphthoyl chloride are dissolved in 40 ml absolute dichloromethane and added dropwise under ice cooling The mixture is stirred for two hours at RT without further cooling Subsequently, the batch is made alkaline with 10% sodium hydroxide solution and washed twice with a small amount of water The organic phase is dried over sodium sulfate and the solvent is removed under vacuum The resinous residue is chromatographically purified over silica gel with CHCl 3 /CH 3 OH (96/4) Yield of colorless resin 5 4 g (59%) C 28 H 33 N 3 O 2 (443 6) IR-spectrum (KBr) v(NH) 3280 cm '1 v(C=O) 1620, 1545 cm ' Η-NMR-spectrum (CDC1 3 ) 1 00 - 2 05 (1 IH, m, piperidine, pιpeπdιne-(CH 2 ) 3 ) 2 55 (2H, t, CO-CH 2 , J=7 5 Hz) 2 70 - 3 45 (6H, m, piperidine, py-CH 2 , CONHCHz) 3 65 - 4 15 (IH, m, piperidine) 4 50 - 5 05 (IH, m, piperidine) 5 60 - 5 85 (lH, m, NH) 7 20 - 7 35 (IH, m, py) 7 50 - 7 75 (4H, m, ar, py) 7.85- 8.10 (4H, m, ar) 8.40 - 8.65 (2H, m, py) Example 19 N-(4-piperidin-4-yl-butyl)-3-(pyridin-3-yl)-propionamide (substance 12) 100 g (219.5 mmol) N-[4-(l-diphenylmethyl-piperidin-4-yl)-butyl]-3-(pyridin-3-yl)- propionamide (substance 54) are dissolved in 500 ml ethanol and added to 8.0 g palladium (5%) on activated carbon (moistened with 40 ml water) and 25 ml cone, hydrochloric acid. The mixture is heated to ca. 45°C and stirred ca. five hours long under hydrogen atmosphere until the consumption of the theoretical amount of hydrogen to be taken up. After cooling, this is filtered from the catalyst and the solvent is removed under vacuum. The residue is taken up in 200 ml water and washed three times with a total of 200 ml CHC1 3 . The organic phases are discarded and the aqueous phase is made alkaline with 1 1 g sodium hydroxide and extracted three times, each with 100 ml CHCI3. After washing the organic phase with 30 ml water, the solvent is removed under vacuum. The oily residue is filtered over silica gel with CHCI3/CH3OH/NH 4 OH (80/20/2). Yield of a slowly hardening resin: 53.0 g (83%). C 17 H 27 N 3 O (289.4) IR-spectrum (KBr): v(NH) 3300 cm " v(C=O) 1630, 1540 cm " Η-NMR-spectrum (CDCI3): 0.90 - 1.80 (1 1 H, m, piperidine, pιperidine-(CH 2 ) 3 ) 2.35 - 2.75 (4H, m, CO-CH 2 , piperidine) 2.80 - 3.35 (6H, m, piperidine, py-CH 2 , CONHCH ) 6.05 - 6.40 (IH, m, NH) 7.10 - 7.35 (IH, m, py) 7 40 - 7 60 (IH, m, py) 8.30 - 8 55 (2H, m, py) Example 20 N-(4-piperidin-4-yI-butyl)-3-(pyridin-3-yl)-pentanoic acid amide (substance 13) Production occurs analogously to example 19 Batch size 37 0 g (76.5 mmol) 5-(pyridin-3-yl)-pentanoic acιd-[4-(l-dιphenylmethyl- pιpeπdιn-4-yl)-butyl]-amide (substance 90)), 2 6 g palladium (5%) on activated carbon (moistened with 15 ml water) and 17 ml cone hydrochloric acid in 200 ml ethanol Reactions time ca 8 hours In the work up, the aqueous phase is alkalized with 9.5 g sodium hydroxide solution and extracted three times with CHCI 3 (100 ml. 20 ml and 20 ml) After washing the organic phase twice, each with 20 ml water, the solvent is removed under vacuum and the oily residue is dried under high-vacuum Yield of a gradually hardening orange colored resin 24.0 g (98%) IR-spectrum (KBr): v(NH) 3290 cm '1 v(CO) 1630, 1540 cm "1 Η-NMR-spectrum (CDCI3) 0 70 - 1.90 (16H, m, piperidine, NH piperidιne-(CH 2 ) 3 , C-(CH 2 ) 2 -C) 2 00 - 2.35 (2H, m, CO-CH 2 ) 2.35 - 2.75 (4H, m, piperidine, py-CH 2 ) 2.90 - 3.40 (4H, m, piperidine, CONHCHj) 5.40 - 5.75 (lH, m, NH) 7.10 - 7.30 (lH, m, py) 7.40 - 7.60 (lH, m, py) 8.30 - 8.55 (2H, m, py) A series of synthesis examples are additionally listed in the following table 2 for further illustration of the invention. Table 2: Prepared compounds of formula (I) Table annotation MeOH = methanol iPr 2 O = diisopropylether BuCI = 1-chlorobutane EE = ethyl acetate EtOH = ethanol MeCN = acetonitrile iPrOH = isopropanol PE = petroleum ether MTBE = methyl tert-butyl ether as a trihydrochloride purified by column chromatography Several examples for the synthesis of the starting materials are given in the following for a better understanding of the production methods for the end products SYNTHESIS OF STARTING PRODUCTS Example 1A 4-(l-diphenylmethyl-piperidin-4-yl)-butylamine 88 9 g (196 mmol) 2-[4-(l-dιphenylmethyl-pιpeπdιn-4-yl)-butyl]-ιsoιndol-l,3-dιone are suspended in 1000 ml ethanol and added to 22 0 g (440 mmol) hydrazine hydrate and heated to boiling for four hours After cooling, the mixture is filtered and the solvent is removed under vacuum The solid residue is dispersed in the heat together with the filter residue between 300 ml 10% sodium hydroxide solution and 300 ml acetic acid ethyl ester The aqueous phase is extracted once with 150 ml warm acetic acid ethyl ester The combined organic phases are extracted twice, each with 300 ml 10% hydrochloric acid The combined aqueous phases are made basic with 10% sodium hydroxide solution and extracted twice, each with 400 ml acetic acid ethyl ester The combined organic phases are washed with 100 ml water and dried over sodium sulfate The solvent is removed under vacuum, the residue is dried under high- vacuum and processed further without additional purification Yield of a gradually hardening resin 63 g (99%) Example 2A 2-[4-(l-diphenylmethyl-piperidin-4-yl)-butyl]-isoindol-1.3-dione 135 0 g (417 mmol) 4-(l-dιphenylmethyl-pιpeπdιn-4-yl)-butan-l-ol, 109 5 g (417 mmol) tπphenylphosphine and 61 3 g (417 mmol) phthahmide are suspended in THF Thereafter, 2 6 g (417 mmol) azodicarboxylic acid diethyl ester are added dropwise within two and a half hours under protective atmosphere and light cooling (ca 15- 25°C) After an additional hour, the solvent is removed under vacuum and the residue is crystallized three times from acetic acid ethyl ester (1000 ml, 1200 ml and 1 100 ml) Colorless crystals with an MP of 150-152°C, yield 103 g (54 5 %) Example 3A 4-(l-diphenylmethyl-piperidin-4-yl)-butan-l-ol 120 g (620 mmol) 4-pιpeπdιn-4-yl-butan-l -ol hydrochloride are suspended in 400 ml 3,4-dιhydro-2H-pyran and added to 1 5 g pyπdimum tosylate and 5 ml 8 M methaneolic hydrochloric acid This is stirred for three hours and left to stand at RT overnight After addition of 5 g potassium carbonate, this is concentrated under vacuum to dryness The resulting 4-[4-Tetrahydro-pyran-2-yloxy)-butyl]-pιpeπdιne is dissolved in 500 ml acetonitrile without further purification and added to 193 g (742 mmol) diphenylmethyl bromide (95%) and 160 g (1157 mmol) potassium carbonate and stirred for three days at RT The mixture is filtered and the filtrate is stirred with a further 20 g (76 8 mmol) diphenylmethyl bromide (95%) and 16 g (1 15 8 mmol) potassium carbonate for one day at RT The mixture is filtered and the solvent is removed under vacuum The resulting l-dιphenylmethyl-4-[4-(tetrahydro-pyran-2- yloxy)-butyl]-pιpeπdιne is dissolved in 700 ml methanol without further purification, added to 120 ml cone hydrochloric acid and the mixture is left to stand for two days at RT Subsequently, the solvent is drawn off under vacuum, the residue is taken up with 1500 ml water and extracted with 1500 ml acetic acid ethyl ester The organic phase is discarded and the aqueous phase is made alkaline with 95 g sodium hydroxide and extracted with 700 ml acetic acid ethyl ester After washing the organic phase with 200 ml water, this is dried over sodium sulfate and the solvent is removed under vacuum The brown oil is dried under high-vacuum and further processed without additional purification Yield 145 g (72%) Example 4A 3-(l-benzylpiperidin-4-yloxy)-propylamine 10 g (40 9 mmol) 3-(l-benzylpιpendιn-4-yloxy)-propιonιtπle are dissolved in 100 ml ethanol and added to a spatula tip Raney-Nickel The mixture is stirred at RT and under hydrogen atmosphere until the consumption of the theoretical amount of hydrogen to be taken up (ca two days) Subsequently, this is filtered from the catalyst and the solvent is removed under vacuum The residue is distilled in a bulb tube apparatus Yield of a colorless oil 7 5 g (73%) Example 5A N-l-(l-diphenylmethyl-piperidin-4-yl)-ethan-l,2-diamine 10 g (37 7 mmol) N-dιphenylmethyl-4-pιpeπdone and 22 2 g (349 mmol) ethylenediamme are dissolved in methanol and added to 1 7 g (45 2 mmol) sodium borohydπde The mixture is stirred for two hours at RT Subsequently, the solvent is removed under vacuum The residue is dispersed between CHC1 3 and water and the aqueous phase is extracted twice, each with 100 ml CHC1 3 The combined organic phases are dried over sodium sulfate and the solvent is removed under vacuum The residue is chromatographically purified over silica gel with CHC /CHiOH/N t OH (90/10/0 to 90/10/1) Yield 1 1 2 g (96%) Example 6A 5-(l-diphenylmethyl-piperidin-4-yl)-pentylamine 19 0 g (57 1 mmol) 5-(l-dιphenylmethyl-pιpeπdιn-4-yl)-pentanιtnle are dissolved in 240 ml dioxane/ethanol (1/1) and added to 3 2 g Raney-Nickel The mixture is stirred at RT under hydrogen atmosphere until the uptake of the theoretical amount of hydrogen The mixture is filtered from the catalyst and the solvent is removed under vacuum The residue is dispersed between 100 ml water and 250 ml acetic acid ethyl ester The organic phase is dried with sodium sulfate and the solvent is removed under vacuum The resin is further processed without additional purification Yield 17 0 g (88%) Example 7A 5-(l-diphenylmethyl-piperidin-4-yl)-pentannitrile 24 9 (69 2 mmol) 4-(l-dιphenylmethyl-pιpeπdιn-4-yl)-butan-l-ol hydrochloride are suspended in 160 ml absolute dichloromethane and cooled to ca 0°C under moisture exclusion At this temperature, 16 0 g (159 mmol) TEA are first added and thereafter a solution of 0 3 g (90 0 mmol) methanesulfonoic acid chloride in a little absolute dichloromethane is added dropwise The mixture is then subsequently stirred for three hours at RT and then placed in ice water The organic phase is washed once with 50 ml water, dried over sodium sulfate and the solvent is removed under vacuum The resulting methanesulfonoic acιd-4-(l-dιphenylmethyl-pιpeπdιn-4-yl)-butyl ester is dissolved in 120 ml DMF without further purification and with 7 7 g (158 mmol) sodium cyanide and two drops 15-crown-5 and stirred for six hours at 65°C After cooling, the mixture is poured in ice water The precipitated solid is drawn off and dried at 40°C in high-vacuum The solid is processed further without additional purification Yield 19 9 g (86%) Example 8A l-diphenylmethyl-piperidin-3-carboxylic acid-(4-aminobutyl)-amide Analogously to example 3, 5 6 g (16.8 mmol) l-diphenylmethyl-pιpeπdιn-3-carboxylιc acid hydrochloride is reacted with 3.8 g (30 1 mmol) oxalyl chloride to the acid chloride This is suspended in absolute dichloromethane and added to 2 28 g (15 3 mmol) N-(tert-butoxycarbonyl)-butanediamιne and 1 55 g (15 3 mmol) TEA and stirred at RT overnight The mixture is subsequently concentrated, taken up in CHC1 3 and washed once with 50 ml 10% sodium hydroxide solution and twice, each with 50 ml water. The organic phase is dried over sodium sulfate and the solvent is removed under vacuum The residue is chromatographically purified over silica gel CHC1 3 /CH 3 0H (98/2 to 96/4) and dissolved in 70 ml ethanol After addition of 5 ml cone hydrochloric acid, the mixture is heated to boiling for 5 hours. After cooling, the solvent is removed under vacuum and azeotropically dehydrated twice with toluene and subsequently dried under high-vacuum The resin is further processed without additional purification. Yield. 5.9 g (81%). Example 9A l-diphenylmethyl-piperidin-3-carboxylic acid hydrochloride 15 7 g (100 mmol) piperidin-3 -carboxylic acid ethyl ester and 30 4 g (220 mmol) potassium carbonate are placed in 100 ml DMF and 24.1 g diphenylmethyl bromide is added dropwise The mixture is stirred at RT overnight and subsequently filtered The filtrate is concentrated under vacuum and the residue is taken up with 150 ml acetic acid ethyl ester, then extracted twice, each with 50 ml 10% hydrochloric acid The organic phase is discarded and the combined aqueous phases are made basic with 10% sodium hydroxide solution and extracted twice, each with 50 ml acetic acid ethyl ester The combined organic phases are cooled to ca. 0°C and the precipitated solid is drawn off and dried Yield 20.5 g (63%) of the compound l-dιphenylmethyl-pιperidιn-3- carboxylic acid ethyl ester with a MP of 166-168°C. This compound is heated to boiling together with 24 ml 20% hydrochloric acid in 100 ml water for 8 hours. After cooling, the precipitate is filtered and crystallized from 70 ml methanol. Yield: 15.6 g (74%). The active ingredients according to the invention can be processed to the desired medicaments in the form of their acid addition salts, hydrates or solvates individually or in combination with each other, optionally under addition of other active ingredients, for the indications tumor treatment or immunosuppression. In the case of the combination of active ingredients according to the invention with other medicinal forms, these can also optionally be separately present next to each other in the medicine packaging, for example as tablets next to viles, depending on the requirements. Further subject-matter of the invention is a method for the treatment of the human or animal body in which a compound or compound mixture according to formula (I), wherein the substituents have the above described meaning, is administered for treatment of tumors and/or as a cytostatic agent, cancerostatic agent, immunosuppressing agent, optionally in combination with further cytostatic or immunosuppressive active ingredients or other active ingredients suitable in the named indications. Furthermore, the invention relates to a compound or compound mixture according to formula (I) for use in a therepeutic method in which the therapeutic use is carried out in connection with one or more medical indications with tumors or for immunosuppression, optimally in combination with further pharmaceuticals suitable in the named indications. The use of one or more compounds according to formula (I) for the production of medicaments for the treatment of the human or animal body, especially in connection with one or more medical indications in the treatment of tumors or for immunosuppression, optimally in combination with further pharmaceuticals suitable in these indications or the use of compounds according to formula (I) in a corresponding diagnosis method represent an embodiment according to the invention The respective suitable tumor indications are illustrated in the last section of the description in the discussion of the pharmacological test results A method for the production of medicaments with an amount of one or more compounds according to formula (I) which are suitable for the processing of these active ingredients together with respective suitable pharmaceutically acceptable carriers and adjuvants for finished medicinal forms equally belongs to the scope of protection according to the invention Depending on the medical indication being considered, the respective suitable medical form is selected for the suitable therapeutic application The invention also relates to the use of the compounds according to formula (I) for treatment in the above indications The production of the respective suitable medicaments as well as a series of examples of medicinal forms are described in the following for better understanding of the invention Therapeutic Administration Forms The production of medicaments with an amount of one or more compounds according to the invention and/or their use in the application according to the invention occurs in the customary manner by means of common pharmaceutical technology methods For this, the active ingredients as such or in the form of their salts are processed together with suitable, pharmaceutically acceptable adjuvents and carriers to medicinal forms suitable for the various indications and types of application Thereby, the medicaments can be produced in such a manner that the respective desired release rate is obtained, for example a quick flooding and/or a sustained or depot effect Preparations for parenteral use, to which injections and infusions belong, are among the most important systemically employed medicaments for tumor treatment as well as for other indications Preferably, injections are administered for the treatment of tumors These are prepared either in the form of vials or also as so-called ready-to-use injection preparations, for example as ready-to-use syringes or single use syringes in addition to perforation bottles for multiple withdrawals Administration of the injection preparations can occur in the form of subcutaneous (s c ), intramuscular (1 m ), intravenous (1 v ) or intracutaneous (1 c ) application The respective suitable injection forms can especially be produced as solutions, crystal suspensions, nanoparticular or colloid-disperse systems, such as for example, hydrosols The injectable formulations can also be produced as concentrates which can be adjusted with aqueous isotonic dilution agents to the desired active ingredient dosage Furthermore, they can also be produced as powders, such as for example lyophihsates, which are then preferably dissolved or dispersed immediately before application with suitable diluents The infusions can also be formulated in the form of isotonic solutions, fat emulsions, hposome formulations, microemulsions and liquids based on mixed micells, for example, based on phosphohpids As with injection preparations, infusion formulations can also be prepared in the form of concentrates to dilute The injectable formulations can also be applied in the form of continuous infusions as m stationary as well as in out-patient therapy, for example in the form of mini-pumps Albumin, plasma expanders, surface active compounds, organic solvents, pH influencing compounds, complex forming compounds or polymeric compounds can be added to the parenteral medicinal forms, especially as substances for influencing the adsorption of the active ingredients to protein or polymers or also with the aim of decreasing the adsorption of the active ingredient to materials such as injection instruments or packaging materials, for example plastic or glass The active ingredients can be bound to nanoparticles in the preparations for parenteral use, for example on finely dispersed particles based on poly(meth)acrylates, polyacetates, polyglycolates, polyamino acids or polyether urethanes The parenteral formulations can also be constructively modified as depot preparations, for example on the multiple unit principle, where the active ingredients are incorporated in a most finely distributed and/or dispersed, suspended form or as crystal suspensions, or on the single unit principle, where the active ingredient is enclosed in a medicinal form, for example, a tablet or a seed which is subsequently implanted Often, these implantations or depot medicaments in single unit and multiple unit medicinal forms consist of so- called biodegradable polymers, such as for example, polyether urethanes of lactic and glycolic acid, polyether urethanes, polyamino acids, poly(meth)acrylates or polysacchaπdes Sterilized water, pH value influencing substances, such as for example organic and inorganic acids or bases as well as their salts, buffer substances for setting the pH value, agents for lsotonicity, such as for example sodium chloride, monosodium carbonate, glucose and fructose, tensides and/or surface active substances and emulsifiers, such as for example, partial fatty acid esters of polyoxyethylene sorbitan (Tween®) or for example fatty acid esters of polyoxethylene (Cremophor®), fatty oils such as for example peanut oil, soybean oil and castor oil, synthetic fatty acid esters, such as for example ethyl oleate, isopropyl myπstate and neutral oil (Miglyol®) as well as polymer adjuvents such as for example gelatin, dextran, polyvinylpyrrohdone, organic solvent additives which increase solubility, such as for example propylene glycol, ethanol, N,N-dιmethylacetamιde, propylene glycol or complex forming compounds such as for example citrates and urea, preservatives, such as for example hydroxypropyl benzoate and hydroxymethyl benzoate, benzyl alcohol, anti-oxidants, such as for example sodium sulfite and stabilizers, such as for example EDTA, are suitable as adjuvents and carriers in the production of preparations for parenteral use In suspensions, addition of thickening agents to prevent the settling of the active ingredients from tensides and peptizers, to secure the ability of the sediment to be shaken, or complex formers, such as EDTA, ensues This can also be achieved with the various polymeric agent complexes, for example with polyethylene glycols, polystyrol, carboxymethylcellulose, Pluronics® or polyethylene glycol sorbitan fatty acid esters The active ingredient can also be incorporated in liquid formulations in the form of inclusion compounds, for example with cyclodextπns As further adjuvents, dispersion agents are also suitable For production of lyophilisates, builders are also used, such as for example mannite, dextran, saccharose, human albumin, lactose, PVP or gelatin varieties As long as the active ingredients are not incorporated in the liquid medicinal formulations in the form of a base, they are used in the form of their acid addition salts, hydrates or solvates in the preparations for parenteral use A further systemic application form of importance is peroral administration as tablets, hard or soft gelatin capsules, coated tablets, powders, pellets, microcapsules, oblong compressives, granules, chewable tablets, lozenges, gums or sachets These solid peroral administration forms can also be prepared as sustained action and/or depot systems Among these are medicaments with an amount of one or more micronized active ingredients, diffusions and erosion forms based on matrices, for example by using fats, wax-like and/or polymeric compounds, or so-called reservoir systems As a retarding agent and/or agent for controlled release, film or matrix forming substances, such as for example ethylcellulose, hydroxypropylmethylcellulose, poly(meth)acrylate derivatives (for example Eudragit®), hydroxypropylmethylcellulose phthalate are suitable in organic solutions as well as in the form of aqueous dispersions In this connection, so-called bio-adhesive preparations are also to be named in which the increased retention time in the body is achieved by intensive contact with the mucus membranes of the body An example of a bio-adhesive polymer is the group of Carbomers® For subhngual application, compressives, such as for example non-disintegrating tablets in oblong form of a suitable size with a slow release of active ingredient, are especially suitable For purposes of a targeted release of active ingredients in the various sections of the gastrointestinal tract, mixtures of pellets which release at the various places are employable, for example mixtures of gastric fluid soluble and small intestine soluble and/or gastric fluid resistant and large intestine soluble pellets The same goal of releasing at various sections of the gastrointestinal tract can also be conceived by suitably produced laminated tablets with a core, whereby the coating of the agent is quickly released in gastric fluid and the core of the agent is slowly released in the small intestine milieu The goal of controlled release at various sections of the gastrointestinal tract can also be attained by multilayer tablets The pellet mixtures with differentially released agent can be filled into hard gelatin capsules Anti-stick and lubricant and separating agents, dispersion agents such as flame dispersed sihcone dioxide, dismtegrants, such as various starch types, PVC, cellulose esters as granulating or retarding agents, such as for example wax-like and/or polymeric compounds on the basis of Eudragit®, cellulose or Cremophor® are used as a further adjuvents for the production of compressives, such as for example tablets or hard and soft gelatin capsules as well as coated tablets and granulates Anti-oxidants, sweetening agents, such as for example saccharose, xylite or mannite, masking flavors, aromatics, preservatives, colorants, buffer substances, direct tableting agents, such as for example microcrystalline cellulose, starch and starch hydrolysates (for example Celutab®), lactose, polyethylene glycols, polyvinylpyrrohdone and dicalcium phosphate, lubricants, fillers, such as lactose or starch, binding agents in the form of lactose, starch varieties, such as for example wheat or corn and/or rice starch, cellulose derivatives, for example methylcellulose, hydroxypropylcellulose or silica, talcum powder, stearates, such as for example magnesium stearate, aluminum stearate, calcium stearate, talc, siliconized talc, stearic acid, acetyl alcohol and hydrated fats are used In this connection, oral therapeutic systems constructed especially on osmotic principles, such as for example GIT (gastrointestinal therapeutic system) or OROS (oral osmotic system), are also to be mentioned Effervescent tablets or tabs both of which represent immediately drinkable instant medicinal forms which are quickly dissolved or suspended in water are among the perorally administratable compressives Among the perorally administratable forms are also solutions, for example drops, juices and suspensions, which can be produced according to the above given method, and can still contain preservatives for increasing stability and optionally aromatics for reasons of easier intake, and colorants for better differentiation as well as antioxidants and/or vitamins and sweeteners such as sugar or artificial sweetening agents This is also true for inspisated juices which are formulated with water before ingestion Ion exchange resins in combination with one or more active ingredients are also to be mentioned for the production of liquid ingestable forms A special release form consists in the preparation of so-called floating medicinal forms, for example based on tablets or pellets which develop gas after contact with body fluids and therefore float on the surface of the gastric fluid Furthermore, so-called electronically controlled release systems can also be formulated by which active ingredient release can be selectively adjusted to individual needs A further group of systemic administration and also optionally topically effective medicinal forms are represented by rectally applicable medicaments Among these are suppositories and enema formulations The enema formulations can be prepared based on tablets with aqueous solvents for producing this administration form Rectal capsules can also be made available based on gelatin or other carriers Hardened fat, such as for example Witepsol®, Massa Estaπnum®, Novata®, coconut fat, glycerol-gelatin masses, glycerol-soap-gels and polyethylene glycols are suitable as suppository bases For long-term application with a systematic active ingredient release up to several weeks, pressed implants are suitable which are preferably formulated on the basis of so-called biodegradable polymers As a further important group of systemically active medicaments, transdermal systems are also to be emphasized which distinguish themselves, as with the above-mentioned rectal forms, by circumventing the liver circulation system and/or liver metabolism These plasters can be especially prepared as transdermal systems which are capable of releasing the active ingredient in a controlled manner over longer or shorter time periods based on different layers and/or mixtures of suitable adjuvents and carriers Aside from suitable adjuvents and carriers such as solvents and polymeric components, for example based on Eudragit®, membrane infiltration increasing substances and/or permeation promoters, such as for example oleic acid, Azone®, adipinic acid derivatives, ethanol, urea, propylglycol are suitable in the production of transdermal systems of this type for the purpose of improved and/or accelerated penetration As topically, locally or regionally administration medicaments, the following are suitable as special formulations vaginally or genitally applicable emulsions, creams, foam tablets, depot implants, ovular or transurethral adminstration installation solutions For opthalmological application, highly sterile eye ointments, solutions and/or drops or creams and emulsions are suitable In the same manner, corresponding otological drops, ointments or creams can be designated for application to the ear For both of the above-mentioned applications, the adminstration of semi-solid formulations, such as for example gels based on Carbopols® or other polymer compounds such as for example polyvinylpyrohdone and cellulose derivatives is also possible For customary application to the skin or also to the mucus membrane, normal emulsions, gels, ointments, creams or mixed phase and/or amphiphihc emulsion systems (oil/water-water/oil mixed phase) as well as hposomes and transfersomes can be named Sodium algenate as a gel builder for production of a suitable foundation or celluolose derivatives, such as for example guar or xanthene gum, inorganic gel builders, such as for example aluminum hydroxides or bentomtes (so-called thixotropic gel builder), polyacryhc acid derivatives, such as for example Carbopol®, polyvinylpyrohdone, microcrystalline cellulose or carboxymethylcellulose are suitable as adjuvents and/or carriers Furthermore, amphiphihc low and high molecular weight compounds as well as phosphohpids are suitable The gels can be present either as hydrogels based on water or as hydrophobic organogels, for example based on mixtures of low and high molecular paraffin hydrocarbons and vaseline Anionic, cationic or neutral tensides can be employed as emulsifiers, for example alkalized soaps, methyl soaps, amine soaps, sulfanated compounds, cationic soaps, high fatty alcohols, partial fatty acid esters of sorbitan and polyoxyethylene sorbitan, for example lanette types, wool wax, lanolin, or other synthetic products for the production of oil/water and/or water/oil emulsions Hydrophihc organogels can be formulated, for example, on the basis of high molecular polyethylene glycols These gel-like forms are washable Vaseline, natural or synthetic waxes, fatty acids, fatty alcohols, fatty acid esters, for example as mono-, di-, or tπglyceπdes, paraffin oil or vegetable oils, hardened castor oil or coconut oil, pig fat, synthetic fats, for example based on acrylic, capπnic, lauπc and stearic acid, such as for example Softisan® or tπglyceπde mixtures such as Miglyol® are employed as Iipids in the form of fat and/or oil and/or wax-like components for the production of ointments, creams or emulsions Osmotically effective acids and bases, such as for example hydrochloric acid, citric acid, sodium hydroxide solution, potassium hydroxide solution, monosodium carbonate, further buffer systems, such as for example citrate, phosphate, Tπs-buffer or tπethanolamine are used for adjusting the pH value Preservatives, for example such as methyl- or propyl benzoate (parabenes) or sorbic acid can be added for increasing stability Pastes, powders or solutions are to be mentioned as further topically applicable forms Pastes often contain lipophilic and hydrophihc auxiliary agents with very high amounts of fatty matter as a consistency-giving base Powders or topically applicable powders can contain for example starch varieties such as wheat or rice starch, flame dispersed silicon dioxide or silica, which also serve as diluents, for increasing flowabihty as well as lubricity as well as for preventing agglomerates Nose drops or nose sprays serve as nasal application forms In this connection, nebulizers or nose creams or ointments can come to use Furthermore, nose spray or dry powder formulations as well as controlled dosage aerosols are also suitable for systemic administeration of the active ingredients These pressure and/or controlled dosage aerosols and dry powder formulations can be inhaled and/or insufflated Administration forms of this type also certainly have importance for direct, regional application in the lung or bronchi and larynx Thereby, the dry powder compositions can be formulated for example as active ingredient-soft pellets, as an active ingredient-pellet mixture with suitable carriers, such as for example lactose and/or glucose For inhalation or insufflation, common applicators are suitable which are suitable for the treatment of the nose, mouth and/or pharynx The active ingredients can also be applied by means of an ultrasonic nebulizing device As a propellant gas for aerosol spray formulations and/or controlled dosage aerosols, tetrafluoroethane or HFC 134a and /or heptafluoropropane or HFC 227 are suitable, wherein non-fluoπnated hydrocarbons or other propellants which are gaseous at normal pressure and room temperature, such as for example propane, butane or dimethyl ether can be preferred Instead of controlled dosage aerosols, propellant-free, manual pump systems can also be used The propellant gas aerosols can also suitably contain surface active adjuvents, such as for example isopropyl myπstate, polyoxyethylene sorbitan fatty acid ester, sorbitan tπoleate, lecithins or soya lecithin For regional application in situ, solutions for installation, for example for transurethral administration in bladder tumors or genital tumors, or for profusion in liver tumors or other organ carcinomas are suitable The respective suitable medicinal forms can be produced in accordance with the prescription and procedures based on pharmaceutical-physical fundamentals as they are described for example in the following handbooks and are included in the present inventive subject-matter with respect to the production of the respective suitable medicaments Physical Pharmacy (A N Martin, J Swarbπck, A Cammarata), 2nd Ed , Philadelphia Pennsylvania, (1970), German version Physikahsche Pharmazie, (1987), 3rd edition, Stuttgart, R Voigt, M Bornschein, Lehrbuch der pharmazeutischen Technologie, Verlag Chemie, Weinheim, (1 84), 5th edition, P H List, Arzneimformenlehre, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, (1985), 4th edition, H Sucker, P Fuchs, P Speiser, Pharmazeutische Technologie, Georg Thieme Verlag, Stuttgart - New York, (1991), 2nd edition, A T Florence, D Attwood, Physicochemical Principles of Pharmacy, The Maximilian Press Ltd , Hong Kong, (1981), L A Trissel, Handbook on Injectable Drugs, American Society of Hospital Pharmacists, (1994), 8th edition, Y W Chien, Transdermal Controlled Systemic Medications, Marcel Dekker Inc , New York - Basel, (1987), K E Avis, L Lachmann, H A Liebermann, Pharmaceutical Dosage Forms Parenteral Medications, volume 2, Marcel Dekker Inc , New York - Basel, (1986), B W Muller, Controlled Drug Delivery, Paperback APV, volume 17, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, (1987), H Asch, D Essig, P C Schmidt, Technologie von Salben, Suspensionen und Emulsionen, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, (1984), H A Liebermann, L Lachman, J.B. Schwartz, Pharmaceutical Dosage forms Tablets, Volume 1 , Marcel Dekker Inc , New York, 2nd Edition (1989), D Chuhn, M Deleuil, Y Pourcelot, Powder Technology and Pharmaceutical Processes, in J C Williams, T Allen, Handbook of Powder Technology, Elsevier Amsterdam - London - New York - Tokyo, (1994), J.T. Carstensen, Pharmaceutical Principles of Solid Dosage Forms, Technomic Publishing Co., Inc., Lancaster - Basel, (1993). PRODUCTION EXAMPLES 1. Injection therapeutics a) Parenteral Solution active ingredient used according to the invention acid sodium phosphate sodium tartrate benzyl alcohol water for injection purposes The solution is produced according to the customary method, sterilized and filled into 10 ml vials. One vial contains 50 mg of the compound according to the invention. b) Penteral Solution active ingredient used according to the invention 1.000 g hydrochloric acid, dilute 5.000 g sodium chloride 6.000 g water for injection purposes to 1000.000 ml The solution is produced according to a customary method by stirring; the medicinal form is adjusted to a suitable pH value by acid addition and subsequently filled into 100 ml vials and sterilized. A vial contains 100 mg of the compound according to the invention. c) Parenteral Dispersion active ingredient used according to the invention 10.000 g soya lecithin 20.000 g saturated triglycerides 100.000 g sodium hydroxide 7.650 g water for injection purposes to 1000 000 ml The active ιngredιent(s) used according to the invention is dispersed in the saturated triglycerides Then the soya lecithin is added under stirring, and subsequent to this, the aqueous solution of sodium hydroxide is added with subsequent homogenization The dispersion is sterilized and filled into 10 ml vials A vial contains 50 mg of the compound according to the invention. d) Biodegradable Parenteral Depot Medicinal Form active ingredient used according to the invention 10 000 polylactic acid /polygylcolic acid polymer 70 000 polyvinylpyrrohdone 0 200 gelatin 2.000 soya lecithin 2.000 isotonic sodium chloride solution to 1000 000 ml First, the active ingredient is incorporated into the biodegradable polymer comprising polylactic acid and polyglycolic acid by a suitable method (spray drying, solvent- evaporation or phase separation) and subsequently subjected to a sterilization process The particles are introduced into a 2-chamber ready-made syringe in which the adjuvent solution, which is also produced in a sterile manner, is filled The biodegradable microparticles are mixed with the dispersion agent shortly before application and dispersed A ready-made syringe contains 200 mg of the active compound according to the invention e) Parenteral Dispersion for Subcutaneous Installation active ingredient used according to the invention 25,000 g soya lecithin 25,000 g arachis oil 400,000 g benzyl alcohol 50,000 g Miglyole ® to 1000,000 g The active ingredient is dispersed together with soya lecithin and arachis oil The benzyl alcohol is dissolved in Miglyole and added to the dispersion The entire dispersion is sterilized and subsequently filled into vials with 2 ml content A vial contains 50 mg active ingredient f) Parenteral Perfusions Solution The solution named under example b) can also be used for perfusion of liver for example According to need, instead of ampules with injection solution, so-called perforation bottles (vials), which can also be optionally preserved, and infusion solutions with an amount of one or more active ingredients according to the invention can also be made available in the customary manner under addition of buffer substances for adjustment of physiological pH value and/or the isotonicity and/or a best possible suitable pH value for the medicinal form (euhydπa) and optional further required nutrients, vitamins, amino acids, stabhzers and other necessary adjuvents, possibly in combination with further medicinal agents suitable for the mentioned indications 2. Solid, Peroral Administration Medicaments a) Tablets active ingredient used according to the invention 10,000 g lactose 5,200 g starch, soluble 1,800 g hydroxypropylmethylcellulose 900 g magnesium stearate 100 g The above components are mixed with each other and compacted in a conventional manner, wherein a tablet weight of 180 mg is set Each tablet contains 100 mg active ingredient If desired, the tablets obtained in this manner are coated, provided with a film coat and/or enteπcally coated b) Coated Tablet Core active ingredient used according to the invention 10,000 g flame dispersed silicon dioxide 500 g corn starch 2,250 g stearic acid 350 g ethanol 3 0 1 gelatin 900 g purified water 10 0 1 talcum 300 g magnesium stearate 180 g From these components, a granulate is produced which is pressed to the desired coated tablet cores Each core contains 50 mg of active ingredient The core can be further processed in a customary manner to coated tablets If desired, a gastric fluid resistant or retarding film coat can be applied in a known manner c) Drink Suspension in Vials active ingredient used according to the invention 0 050 g glycerin 0 500 g sorbite, 70% solution 0 500 g sodium saccharinate O OlO g methyl-p-hydroxybenzoate 0 040 g aromatic agent q s sterile wasser q s to 5 ml The above-mentioned components are mixed in a customary manner to a suspension and filled in a suitable drink vial having 5 ml content d) Poorly Soluble Sublingual Tablets active ingredient used according to the invention 0 030 g lactose O lOO g stearic acid 0 004 g talcum purum 0 015 g sweetener q s aromatic agent q s rice starch q s to 0 500 g The active ingredient is compacted together with the adjuvents under high pressure to sublingual tablets, favorably in oblong form e) Soft Gel Capsule active ingredient used according to the invention 0 050 g fatty acid glyceπde mixture (Miglyole ) q s to 0 500 g The active ingredient is impasted together with the fluid carrier mixture and mixed together with further adjuvents suitable for the mcapsulation and filled into elastic soft gelatin capsules which are sealed f) Hard Gelatin Capsules active ingredient used according to the invention 0 150 g microcrystalline cellulose O l OO g hydroxypropylmethylcellulose 0 030 g mannite 0 100 g ethylcellulose 0 050 g tπethyl citrate O OlO g The active ingredient is mixed together with the adjuvents, microcrystalline cellulose, hydroxypropylmethylcellulose and mannite, wet with granulation liquid and formed into pellets These are subsequently coated with a solution of ethylcellulose and tπethyl citrate in organic solvents in a fluidized-bed apparatus A hard gelatin capsule contains 150 mg of active ingredient 3. Topically Administratable Medicinal Forms a) Hydrophilic Ointment active ingredient used according to the invention 0 500 g Euceπnum anhydπcum 60 000 g microcrystalline wax 15 000 g vaseline oil q s to 100 000 g The above-mentioned adjuvents are melted and further processed together with the active ingredient to an ointment in a customary manner b) Lipophilic Ointment active ingredient used according to the invention 10.000 g propylene glycol 50.000 g paraffin, liquid 100 000 g paraffin wax 100 000 g vaseline to 1000.000 ml The active ιngredient(s) used according to the invention is dissolved in propylene glycol at ca. 60°C. At the same time, the lipophilic components are melted at 60-70°C and subsequently combined with the active ingredient solution. The ointment is emulsified at first at 60-70°C and subsequently cooled to 35-40°C under constant emulsification and then filled in 10 g tubes. A tube contains 100 mg of the compound according to the invention. 4. Inhalation Therapeutic Further subject-matter is a pharmaceutical formulation which is characterized in that it contians an active ingredient(s) used according to the invention as a base or a physiologically acceptable salt thereof together with carriers and/or diluents customary for this and suitable for administration by means of inhalation. In connection with the production of the medicaments, particularly suitable physiologically acceptable salts of the active ingredients are, as already illustrated in the synthesis section, acid addition salts derived from inorganic or organic acids such as for example especially hydrochloride, hydrobromide, sulfate, phosphate, maleate, tartrate, citrate, benzoate, 4-methoxybenzoate, 2- or 4-hydroxybenzoate, 4- chlorobenzoate, p-tosylate, methaneosulfonate, ascorbate, salicylate, acetate, formate, succinate, lactate, glutarate, gluconate or tπcarballylate. The administration of the active ιngredιent(s) used of the invention by means of inhalation occurs according to the invention in conventional ways customary for administrations of this form, for example in the form of a commercial controlled dosage aerosol or in combination with a spacer In controlled dosage aerosols, a metering valve is delivered with whose help, a dosed amount of the composition is administered For spraying, the present compositions can be formulated for example as aqueous solutions or suspensions and be administered by means of an atomizer Aerosol spray formulations in which the active ingredient is either suspended with one or two stabilizers in a propellant as a carrier and/or diluent, for example tetrafluoroethane or HFC 134a and/or heptafluoropropane or HFC 227 can equally be used, whereby however, non-fluoπnated hydrocarbons or other propellants which are gaseous at normal pressure and room temperature, such as propane, butane or dimethyl ether, can be preferred Thereby, propellant-free manual pump systems or dry powder systems as desπbed below can also be used Suitably, the propellant aerosols can also contain surface active adjuvents, such as for example isopropyl myπstate, polyoxyethylene sorbitan fatty acid ester, sorbitan tπoleate, lecithins, oleic acid For administration by means of inhalation and/or insufflation, the medicaments with an amount of compounds according to the invention can also be formulated in the form of dry powder compositions, for example as active ingredient-soft pellets or as an active ingredient-powder mixture with a suitable carrier, such as for example lactose and/or glucose The powder compositions can be formulated and administered as single doses or as multiple doses The compounds according to the invention are preferably administered by means of a controlled dosage aerosol or in the form of a dry powder dosage formulation, wherein the latter preferably contains glucose and/or lactose as a carrier substance As applicators for inhalation of the pharmaceutical formulations containing one or more of the active ingredιent(s) used according to the invention, all applicators are generally suitable which are suitable for controlled dosage aerosols and/or a dry powder dosage formulation, such as for example usual applicators for the nose, mouth and or pharynx, or also devices standing under propellant gas for the delivery of a spray (as controlled dosage aerosol or dry powder dosage formulation) as they are also used for inhalations in the nose, mouth and/or pharynx A further embodiment can also consist of an aqueous solution of the active ιngredιent(s) used according to the invention, which also optionally contains further active ingredients and/or additives, which are applied by means of an ultrasound atomizer. a) Controlled Dosage Aerosol b) Controlled Dosage Aerosol Intended dose per aerosol per stroke % by weight active ingredient used according to the invention 0 250 mg 0 32 Stabilizer 0.038 mg 0.05 HFC 227 79.180 mg 99 63 In the examples a) and b) the micronized active ingredient is, after previous dispersion in a small amount of the stabilizer, placed in a suspension vessel in which the bulk amount of propellant gas solution is found. The corresponding suspension is dispersed by means of a suitable stirring system (for example high performance mixer or ultrasound mixer) until an ultra-fine dispersion results The suspension is then continuously held in flux in a filling apparatus suitable for cold propellants or pressure fillings. Alternatively, the suspension can also be produced in a suitable cooled stabilizer solution m HFC 134a 227. The examples c) to d) describe the composition and production of dosage dry powder formulations c) Dosage-Dry Powder Formulation mg/dose active ingredient used according to the invention 0.500 mg d) Dosage-Dry Powder Formulation mg/dose active ingredient used according to the invention 0.500 mg lactose Ph. Eur to 2.5 mg or to 5.0 mg e) Dosage-Dry Powder Formulation mg/dose active ingredient used according to the invention lactose Ph Eur Im example c) the active ingredient is formulated after micronization under addition of steam as pellets with an MM AD between 0,1 and 0,3 mm diameter and brought to use in a multi-dose powder applicator In the examples d) and e) the active ingredient is micronized, thereafter, bulk material is mixed with the lactose in the given amounts, and subsequently, filled m a multi-dose powder inhilator In all of the examples set forth above, the active ingredient or the medicinal agent in the form of the respective suitable pharmaceutical acceptable salt and/or acid addition salts can be present, insofar as the base is not preferred in each case In the following, the pharmaceutical test results obtained in connection with the newly found indications based, in a representative manner, on the specifically structured new compounds are described PHARMACEUTICAL EXPERIMENTAL SECTION 1. Growth Inhibition of Human Tumor Cells The tumor growth inhibiting activity of the substances was determined on human tumor cells in standardized in vitro test systems In the screening tests, the substances gave IC5o-values in a concentration range of 0 1 nM to 10 μM Example HepG2 cells plated at a density of 20,000 cells/ml in 12-well plastic dishes Cultivation occured in Richters IMEM-ZO nutrient medium with 5% fetal calf serum (FCS) in a tissue culture incubator with a gas mixture of 5% CO 2 and 95% air at a temperature of 37°C One day after plating, the culture medium was aspirated from the cells and replaced by fresh medium which contained the respective concentrations of the test substances For the individual concentrations and the controls without test substances, three-fold batches were done for each Three days after the beginning of treatment, the medium was again renewed with the test compounds After six days of substance incubation, the test was ended and the protein amount in the individual wells was determined with the sulforhodamin-B-method (according to P Skehan et al New Coloπmetπc Cytotoxicity Assay for Anticancer-Drug Screening J Natl Cancer Inst 82 1 107-1 112, 1990) The IC 5 Q- values (defined as that concentration in which the cell growth was inhibited by 50%) was taken from the dose-response curves and given as a comparative measurement for the activity of the test compounds The following results were obtained 2. Indications The compounds of formula (I) and their salts permit a therapeutic use in malignant illnesses of humans and animals through their excellent inhibition of the growth of tumor cells The anti-neoplastic activity of the described substances can be used for prophylactic, adjunct, palliative, and curative treatment of solid tumors, leukemic illnesses and lymphomas as well as for decreasing or preventing metastasis formation in humans and animals The therapeutic use is possible in the following illnesses for example gynocological tumors, such as of the uterus or the vagina, ovarian carcinomas, testicle tumors, prostate carcinomas, skin cancer, kidney cancer, bladder tumors, esophagus carcinomas, stomach cancer, rectal carcinomas, pancreas carcinomas, thyroid cancer, adrenal tumors, leukemia and lymphomas, such as Hodgkin's disease, tumor illnesses of the CNS, soft-tissue sarcomas, bone sarcomas, benign and malignant mesothehomas, but especially intestine cancer, liver cancer, breast cancer, bronchial and lung carcinomas, melanomas, acute and chronic leukemias Thereby, benign papillomatosis tumors are also considered for therapy The broad activity of the new compounds was tested in vitro on various human tumor cells Thereby, the following IC 50 values were obtained for compound Nr 54 The novel structural class of compounds possesses an independent activity profile in the effectiveness against the various tumor types Thus, tumors which are resistant to customary cytostatic agents, for example, respond entirely to these substances In addition, based on the independent characteristics, combinations of the new compounds with known chemo-therapeutically used pharmaceuticals or other methods of treatment are considered, wherein their various properties are complimented in a suitable manner The integration of the presently used compounds with their specific structures in a therapy scheme is successful with one or more substances from the following classes for example anti-metabolites (for example cytarabine, 5-fluorouracιl, 6-mercaptopuπne, methotrexate), alkylatmg agents (for example busulfan, carmustine, cisplatin, carboplatin, cyclophosphamide, dacarbazine, melphalane, thiotepa), DNA- lntercalating substances and topoisomerase inhibitors (for example actmomycin D, daunorubicin, doxorubicin, mitomycin C, mitoxantrone, etoposide, teniposide, topotecan, lπnotecan), spindle poisons (for example vincπst e, navelbin, taxol, taxoter), hormonally active agents (for example tamoxifen, flutamide, formestan, goserehn) or other cytostatic agents with complex modes of action (for example L- asparaginase, bleomycin, hydroxyurea) Resistant tumor cells can be made sensitive again by interaction of the new compounds with a mechanism of resistance for common cytostatic agents (for example P-glycoprotein, MRP, glutathione-S- transferase, metallothionein) A combination is also suitable with radiation therapy, hyperthermia or immunotherapy 3. Immuno Suppressing Activity Many anti-tumor agents have not only a cytotoxic effect on tumor cells, but also on the blood cell system This leads to a weakening of the immune defence, which can, in turn, be specifically employed to suppress the rejection reaction after an organ transplantation for example Therefore, a use of the main compounds, optionally in combination with other compounds effective for these indications is suitable in diseases such as psoriasis or autoimmune diseases In order to test the possibility for a therapeutic use in illnesses of this type, the substance activity was tested on freshly isolated lymphocytes as follows The spleen of a Swiss mouse served as a lymphocyte source The lymphocyte population was isolated from the spleen cell suspension over a ficoll gradient and taken up in IMEM-ZO culture medium with 0,1% dextran 70,000 and 2% fetal calf serum The cells were plated at a density of ca 500,000 cells/well/ml in a 12-well plate, 1 ml doubly concentrated test substance solution was pipetted per well and this was subsequently incubated in a tissue culture incubator at 37°C and 5% C0 2 After 2 days, a 1 ml-aliquot with 5 μl of the fluorescent dye solutions propidium iodide (8 mg/ml) and 3,3'-dιhexyloxacarbocyanιn iodide (40 μg/ml) each was added per well, and incubated for 3 minutes at room temperature Subsequently, 10,000 cells per each sample were measured on a flow-through cytometer and the percentage amount of vital cells in the population was determined By means of the dose-response curves, IC 50 - values were calculated which were also employed in the following Tables for the characterization of the individual substances Furthermore, the independent class of the compounds used according to the invention also permits a combination with known immunosuppressive agents such as for example cyclospoπn A, tacrohmus, rapamycin, azathiopπn and glucocorticoids The invention is in no way limited to the present respective concretely named active ingredient concentrations, dosages, combinations with one or more other cytostatic agents, tumor inhibitors, cancerostatic agents, immunosuppressive agents or further medicinal agents suitable for the respective specific indications or the type of tumor to treated or immunological illness, etc

Claims: Claims 1 Compounds of formula (I) (I) wherein R 1 hydrogen, halogen, cyano, trifluoromethyl, hydroxy, benzyloxy, aminocarbonyl, carboxy, phenyl, phenoxy, phenylthio, pyridyloxy, pyridylthio, alkyl, especially C]-C6-alkyl, alkenyl, especially C3-Cg-alkenyl, alkinyl, especially C3-C6-alkinyl, hydroxyalkyl, especially C j -Cg-hydroxyalkyl, alkoxy, especially C j -C6-alkoxy, alkenyloxy, especially C3-C6-alkenyloxy, alkinyloxy, especially C3-C6-alkin loxy, alkanoyloxy, especially C \ -Cγ-alkanoyloxy, alkoxycarbonyloxy, especially C2-C7-alkoxycarbonyloxy, alkylthio, especially Ci-Cg-alkylthio, alkenylthio, especially C3-C6-alkenylthio, alkinylthio, especially C3-C6-alkinylthio, cycloalkyl, especially C3-Cg-cycloalkyl, cycloalkyloxy, especially C3-Cg-cycloalkyloxy, cycloalkylthio, especially C3-Cg-cycloalkylthιo, alkoxycarbonyl, especially C2-C7-alkoxycarbonyl, alkylaminocarbonyl, especially C2-C7-alkylaminocarbonyl, dialkylammocarbonyl, especially C3-C 13 -dialkylammocarbonyl, or NR 5 R 6 , wherein R 5 and R*> are selected independently of each other from hydrogen, alkyl, especially Cj-Cg-alkyl, alkenyl, especially C3-Cg-alkenyl and alkinyl, especially C3-Cg-alkinyl, R2 is hydrogen, halogen, cyano, hydroxy, trifluoromethyl, benzyloxy, alkyl, especially Cj-Cό-al yl, alkoxy, especially Cj-Cg-alkoxy or alkanoyloxy, especially Cj -Cy-alkanoyloxy, wherein R and R^, if they are adjacent, optionally form a bridge which is selected from -(CH 2 )4-, -(CH=CH) 2 - and -CH 2 O-CR 7 R 8 -O-, wherein R 7 and R 8 are, independently of each other, hydrogen or alkyl, especially C]-C5-alkyl, R is hydrogen, halogen, alkyl, especially Cj-Cg-alkyl, trifluoromethyl or hydroxyalkyl, especially C 1 -C6-hdroxyalkyl and R4 is hydrogen, hydroxy, benzyloxy, alkyl, especially Cj-Cό-alkyl, alkenyl, especially C3-C6-alkenyl, alkinyl, especially C3-C6-alkιnyl, cycloalkyl, especially C3-Cg-cycloalkyl or alkoxy, especially C j -Cβ-alkoxy, A is alkylene, especially Cι -C6-alkylene, which is optionally substituted once to three-fold by alkyl, especially Cι-C3-alkyl, hydroxy, alkoxy, especially C] -C3- alkoxy, fluorine or phenyl, or 1 ,2-cyclopropylene or alkylene with at least two C-atoms, especially C2-C6-al ylene in which a methylene unit can be isostencally replaced by O, S, NR^, CO, SO or SO 2 , wherein the substitution, with the exception of =CO, cannot be adjacent to the amide group and wherein R IS selected from hydrogen, alkyl, especially C] -Cg-alkyl, alkenyl, especially C3-C6-alkenyl, alkinyl, especially C3-C6-alkιnyl, acyl, especially Ci-Cg-acyl or alkylsulfonyl, especially Cj -Cό-alkylsulfonyl, D is selected from alkylene, especially C j -C ] Q-alkylene, optionally substituted once or twice by alkyl, especially Ci-Cg-al yl, hydroxy, or alkoxy, especially Cj-C5-alkoxy, alkenylene with at least two C-atoms, especially C2-C]o-alkenylene, which is optionally substituted once or twice by alkyl, especially Cj -Cg-alkyl, hydroxy, or alkoxy, especially C ] -C6-alkoxy, wherein the double bond can also be to ring E, alkinylene with at least three C-atoms, especially C3-C] o-alkinylene, optionally substituted once or twice by alkyl, especially Cj-Cg-alkyl, hydroxy or alkoxy, especially C j -Cg-alkoxy, and alkylene, especially Ci-Cjo-alkylene, alkenylene with at least two C-atoms, especially C2-Cιo~ lken lene or alkinylene with at least three C-atoms, especially C3-C]Q-alkinylene, whereby one to three methylene units are each isosterically replaced by O, S, NR 10 , CO, SO or SO2 wherein R Ϊ ® has the same meaning as R^ but is selected independently thereof, E is selected from (El) or (E2) wherein the heterocychc ring can also optionally have a double bond and n and p can be, independently of one another 0, 1, 2 or 3, with the proviso that n + p < 4 and q is 2 or 3, RU is hydrogen, alkyl, especially C] -C6-alkyl, hydroxy, hydroxymethyl, carboxy or alkoxycarbonyl with at least two C-atoms, especially C2-C7-alkoxycarbonyl and R*2 IS hydrogen, alkyl, especially Ci-Cg-alkyl or or an oxo group adjacent to the nitrogen atom, wherein RU and Rl2 optionally together, form an alkylene bridge with 1, 2, 3, 4 or 5 C-atoms, especially a C1-C3 -alkylene bridge under formation of a bicychc ring system, G is selected from hydrogen, Gl, G2, G3, G4 and G5, wherein Gl represents the residue — (CH 2 ) r — (CR"R15 )S _ R 13 (Gl) wherein r is an integer from 1 to 3 or 0 and Rl3 1S selected from hydrogen, alkyl, especially Cj-Cg-alkyl, alkenyl with at least three C-atoms, especially C3-C6-alkenyl, alkinyl with at least three C-atoms, especially C3-C6- lkιnyl, cycloalkyl with at least three C-atoms, especially C3- Cg-cycloalkyl, saturated, five to seven membered heterocycles, which can contain one or two hetero-atoms from the group N and/or S and/or O, benzyl or phenyl, monocyclic aromatic five or six-membered heterocycles, which can contain one to three hetero-atoms from the group N and/or S and/or O and are either bound directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated carbocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated heterocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from N and/or S and/or O and the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, Rl4 has the same meaning as R" 5 but is selected independently thereof, R Ϊ 5 is selected from hydrogen, hydroxy, methyl, benzyl, phenyl, monocyclic aromatic five- or six-membered heterocycles, which can contain one to three hetero-atoms selected from the group N and/or S and/or O and are either bound directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated carbocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated heterocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from N and/or S and/or O and the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, G2 is the residue C (CH 2 ) r (CR 14 R 15 ) S R 13 II (G2a) or C (CH 2 ) r NR 13 R 15 O (G2b) wherein the substituents R^ and * can have the above meaning or the grouping NR 13 R 15 can also be a nitrogen heterocycle bound over the nitrogen atom, selected from saturated or unsaturated monocyclic, four- to eight-membered heterocycles, which, aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from the group N and/or S and/or O, or saturated or unsaturated bi- or tricyclic, anellated or bridged heterocycles with 8 to 16 ring atoms, which, aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from the group N and/or S and/or O, G3 is the residue S0 2 (CH 2 ) r Rl 3 (G3) and G4 is the residue (G4) wherein Ar* and Ar 2 are selected independently from one another from phenyl, pyridyl or naphthyl and G5 is the residue COR 16 (G5) wherein Rl6 is selected from trifluoromethyl, alkoxy, especially Cj-Cg-alkoxy, alkenyloxy, especially C3~C6-alkenyloxy, or benzyloxy, wherein any aryl residues and/or aromatic ring systems in the substituents R*, R 2 , R4 ? R 13 , R 14 , R 15 , R 16 , Ar 1 and Ar 2 and/or in the ring system -NR 13 R 15 can be substituted independently from each other by one to three of the same or different residues which are selected from halogen, cyano, alkyl, especially C}-Cg-alkyl, trifluoromethyl, cycloalkyl, especially C3-Cg-cycloalkyl, phenyl, benzyl, hydroxy, alkoxy, especially C j -C^-alkoxy, alkoxy, substituted entirely or partially by fluorine, substituted alkoxy, especially Cι -C6-alkoxy, benzyloxy, phenoxy, mercapto, alkylthio, especially Cj-Cg-alkylthio, carboxy, alkoxycarbonyl, especially Ci -Cg- alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, monoalkyl amino, especially mono- C] -C6-alkylamino, dialkylamino, especially di-(C]-C6-alkyl)-amino and methylenedioxy for two adjacent groups on the aromatic ring or ring system, wherein each of the residues alkyl, alkenyl, alkinyl, hydroxyalkyl, alkoxy, alkenyloxy, alkinyloxy, alkanoyloxy, alkoxycarbonyl, alkoxycarbonyloxy, alkylthio, alkenylthio, alkinylthio, alkylene, acyl, alkylsulfonyl, alkenylene, alkinylene, cycloalkyl, cyc- loalkyloxy, alkoxycarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl of the substituents R* to R 14 can have 1 to 2 or 4, 6, 8, 10 or 12 C-atoms and/or 2 or 3 to 5, 7, 9, 1 1 or 13 and/or 15 C-atoms or 4, 5, 6, 7, 8, 9, 10, 1 1 , 12, 13, 14 or 15 C-atoms depending on the structure, as well as stereoisomers and/or mixtures thereof and pharmacologically acceptable acid addition salts. 2. Compounds of formula (I) (i) wherein Rl is a hydrogen, halogen, cyano, C i -Cg-alkyl, C3-C6-alkenyl, C3-Cg-alkinyl, trifluoromethyl, C3-Cg-cycloalkyl, C i -Cβ-hydroxyalkyl, hydroxy, C\-C - alkoxy, C3-C6-alkenyloxy, C3-C6-alkinyloxy, benzyloxy, C i -C7-alkanoyloxy, C2"C7-alkoxycarbonyloxy, Cι -C6-alkylthio, C3-C6-alkenylthιo, C3-C6- alkinylthio, C3-Cg-cycloalkyloxy, C3-Cg-cycloalkylthio, C2-C7- alkoxycarbonyl, aminocarbonyl, C2-C7-alkylaminocarbonyl, C3-C13- dialkylaminocarbonyl, carboxy, phenyl, phenoxy, phenylthio, pyridyloxy, pyridylthio, or NR^R", wherein R 5 and R are selected independently from each other from hydrogen, C i-Cg-alkyl, C3- Cg-alkenyl and C3-C6-alkinyl, R 2 is hydrogen, halogen, cyano, Cj-Cg-alkyl, trifluoromethyl, hydroxy, Cj-Cg- alkoxy, benzyloxy or C]-C7-alkanoyloxy, wherein Rl and R 2 , in case they are adjacent, optionally form a bridge which is selected from the bridge members -(CH 2 )4- and -(CH=CH) 2 - and -CH 2 O-CR 7 R 8 -O-, wherein R 7 and R 8 are, independently from each other, hydrogen or Cj-Cg-alkyl, R 3 is hydrogen, halogen, Cj-Cg-alkyl, trifluoromethyl or Ci-Cβ-hydroxyalkyl and R 4 is hydrogen, Ci-Cg-alkyl, C3-Cg-alkenyl, C3-C6-alkinyl, C3-C6-cycloalkyl, hydroxy, C \ -Cg-alkoxy or benzyloxy, k is 0 or 1 , A is C 1 -Cg-alkylene, which is optionally substituted once to three-fold by C j -C3- alkyl, hydroxy, Ci -C3-alkoxy, fluorine or phenyl, or 1,2-cyclopropylene or C2-C6- alkylene, wherein a methylene unit can be isostencally replaced by O, S, NR^, CO, SO or SO2, wherein the isostenc substitution, with the exception of =CO, cannot be adjacent to the amide group, and wherein R9 IS selected from hydrogen, Ci-Cg-alkyl, C3-Cg-alkenyl, C3-Cg-alkιnyl, C ] -Cg- acyl or Ci-Cg-alkylsulfonyl, D is selected from Ci-CiO" lkyl ene > optionally substituted once or twice by C] - Cg-alkyl, hydroxy, or C \ -Cg-alkoxy, C2-Cι o-alkenylene, which is optionally substituted once or twich by C]-Cg- alkyl, hydroxy, or Cj -Cg-alkoxy, wherein the double bond can also be to ring E, C3-CiQ-alkinylene, optionally substituted once or twice by Cj-Cg-alkyl, hydroxy, or Ci -Cg-alkoxy, and wherein C j -C 1 Q-alkylene, C2-C]0" a lkenylene or C3-Cι .ø-alkιnylene, wherein one to three methylene units are each isostencally replaced by O, S, NR*0, CO, SO or SO2, wherein R l " has the same meaning as R^, but is selected independently therefrom, E is selected from (El) or (E2) wherein the heterocychc ring can optionally have a double bond and n and p can be, independently of each other, 0, 1 , 2 or 3, with the proviso that n + p < 4 and Rl 1 is hydrogen, C\ -Cg-alkyl, hydroxy, hydroxymethyl, carboxy or C2-C7- alkoxycarbonyl and R*2 hydrogen, C] -Cg-alkyl or an oxo group adjacent to the nitrogen atom, wherein RU and R* 2 optionally together form a C]-C3 -alkylene bridge under formation of a bi-cychc ring system, G is selected from hydrogen, Gl, G2, G3, G4 and G5, wherein Gl represents the residue {CH 2 ) r (CR η *R 10 ) s R 1 (Gl) wherein r is an integer from 1 to 3 or 0 and R* 3 is selected from hydrogen, C] -Cg-alkyl, C3-Cg-alkenyl, C3-Cg-alkιnyl, C3-C - cycloalkyl, saturated, five- to seven-membered heterocycles, which can contain one or two hetero-atoms from the group N and/or S and/or O, benzyl or phenyl, monocyclic aromatic five or six-membered heterocycles, which can contain one to three hetero-atoms from the group N and/or S and/or O and are either bound directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated carbocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated heterocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from N and/or S and/or O and the linkage can occur either over an aromatic ring or a hydrated ring and either directly or over a methylene group, R Ϊ 4 has the same meaning as R* 3 , but is selected independently thereof, R15 ]S selected from hydrogen, hydroxy, methyl, benzyl, phenyl, monocyclic aromatic five- or six-membered heterocycles, which can contain one to three hetero-atoms selected from the group N and/or S and/or O and are either bound directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated carbocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein the linkage can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated heterocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from N and/or S and/or O and the linkage can occur either over an aromatic ring or a hydrated ring and either directly or over a methylene group, G2 is the residue C (CH 2 ) r (CR 14 R 15 ) S R 13 II (G2a) or C (CH 2 ) r NR 13 R 15 0 (G2b) wherein the substituents R 3 and R" can have the above meaning or the grouping NR 13 R 15 can also be a nitrogen heterocycle bound over the nitrogen atom, selected from saturated or unsaturated monocyclic, four- to eight-membered heterocycles, which, aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from the group N and/or S and/or O, or saturated or unsaturated bi- or tricyclic, anellated or bridged heterocycles with 8 to 16 ring atoms, which, aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from the group N and/or S and/or O, G3 is the residue S0 2 (CH 2 ) r Rl 3 (G3) and G4 is the residue V A ' 1 (G4) wherein Ar* and Ar 2 are selected independently from one another from phenyl, pyπdyl or naphthyl and G5 is the residue COR 16 (G5) wherein R*6 IS selected from tnfluoromethyl, C j -Cg-alkoxy, C3-Cg-alkenyloxy, or benzyloxy, and wherein aromatic ring systems in the substituents R 1 , R 2 , R 4 , R 13 , R 14 , R 15 , R 16 , Ar 1 and Ar 2 and/or in the ring system -NRl R^ can be substituted independently from each other by one to three of the same or different residues which are selected from halogen, cyano, Ci -Cg-alkyl, trifluoromethyl, C3-Cg-Cycloalkyl, phenyl, benzyl, hydroxy, C\- Cg-alkoxy, which can optionally be entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, Ci-Cg-alkylthio, carboxy, C]-Cg-alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, mono-Ci-Cg-alkylamino or dι-(Cι-Cg-alkyl)-amιno and methylenedioxy for two adjacent groups on the aromatic ring or ring system, stereoisomers thereof and/or their mixtures thereof and pharmacologically acceptable acid addition salts 3 Compounds according to one of the claims 1 or 2, characterized in that the substituents R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 13 , R 14 , R 15 and R 16 as well as A and D indicated therein have the following meaning in connection with the substitutions according to formula (I) given in the above claims ( °>k (I) wherein halogen is fluorine, chlorine, bromine or iodine, Cj-Cg-alkyl can be straight chain or branched and is preferably a methyl-, ethyl-, propyl-, isopropyl-, butyl-, isobutyl-, sec-butyl-, tert-butyl-, cyclopropylmethyl-, pentyl-, isopentyl-, tert-pentyl-, neopentyl-, cyclopropylethyl-, cyclobutylmethyl- or a hexyl group, alkylene is for example methylene, ethylene, propylene, tetramethylene, pentamethylene, hexamethylene, heptamethylene, octamethylene, nonamethylene or decamethylene, Cβ-Cg-alkenyl can be straight chain or branched and is preferably an allyl-, 2-butenyl-, 3-butenyl-, 2-methyl-2-propenyl-, 2-pentenyl-, 4-pentenyl-, 2-methyl-2-butenyl-, 3- methyl-2-butenyl-, 2-hexenyl-, 5-hexenyl-, 4-methyl-3-pentenyl- or 2,2-dιmethyl-3- butenyl group, alkenylene is for example ethenylene, propenylene, butenylene, pentenylene, hexenylene, hexathenylene, heptenylene, octenylene, nonenylene or decenylene, C3-Cg-alkinyl can be straight chain or branched and is preferably a propargyl-, 2- butinyl-, 3-butιnyl-, 4-pentιnyl-, 5-hexιnyl- or 4-methyl-2-pentιnyl group, alkinylene is for example propmylene, butinylene, pentinylene, hexinylene, heptinylene, octinylene, noninylene or decinylene, C3-Cg-cycloalkyl is preferably cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl or cyclooctyl, Cj-Cg-hydroxyalkyl contains a hydroxyl group in one of the above-named Cj -Cg- alkyl residues, especially in the form of the hydroxymethyl- and hydroxyethyl group, wherein Cj -Cg-alkoxy, Cβ-Cg-alkenyloxy, C3-Cg-alkinyloxy each contain, aside from the oxygen atom, one of the C]-Cg-alkyl-, C3-Cg-alkenyl- and/or C3-Cg-alkιnyl groups named above and the methoxy-, ethoxy-, isopropoxy-, tert-butoxy-, allyloxy- and propargyloxy group are preferred and is to be understood as among C \ -Cg-alkoxy entirely or partially substituted with fluorine, for example difluormethoxy, tπfluormethoxy or 2,2,2-trιfluorethoxy, Cj-Cg-alkylthio, C^j-Cg-alkenylthio, C3-Cg-alkinylthio each contain, aside from the sulfur atom, one of the Cj -Cg-alkyl-, C3-Cg-alkenyl- or C3-Cg-alkιnyl group named above, especially the methylthio-, ethylthio-, isopropylthio- and tert-butylthio group, C3-Cg-cycloalkyloxy and Cs-Cg-cycloalkylthio are preferred as cyclopentyloxy- and cyclopentylthio- and/or cylohexyloxy- and cyclohexylthio groups, Cj-C7-alkanoyloxy groups contain, aside from the oxygen atom, an aliphatic acyl residue with 1 to 7 carbon atoms, especially the acetoxy-, propionyloxy- and pivaloyloxy group, C2-C7-alkoxycarbonyl groups contain, aside from the carbonyl group, one of the C \ - Cg-alkoxy groups mentioned above, especially the methoxycarbonyl-, ethoxycarbonyl-, lsopropoxycarbonyl-, lsobutoxycarbonyl-and tert-butoxycarbonyl group, C2-C7-alkoxycarbonyloxy groups contain, aside from the oxygen atom, one of the C2"C7-alkoxycarbonyl residues mentioned above, especially the methoxycarbonyloxy-, ethoxycarbonyloxy-, lsopropoxycarbonyloxy-, lsobutoxycarbonyloxy-and tert- butoxycarbonyl group as well as the allyloxycarbonyloxy group, C2"C7-alkylaminocarbonyI and C3-Cj3-dialkylaminocarbonyl groups contain, beside the carbonyl group, an alkylamino- and/or dialkylamino residue, whose C] -Cg- alkyl groups have the above meanings, wherein the dimethylaminocarbonyl-, diethylaminocarbonyl- and the dnsopropylaminocarbonyl groups are preferred, and aside from the unsubstituted amino group, one of the following Ci -Cg-alkylamino groups and/or dι-(C ] -Cg-alkyι)amιno groups are to be understood under the amino groups of the formula NR^R", Cj-Cg-alkylamino contains one of the C\ -Cg-alkyl groups mentioned above, especially in form of the methylamino-, ethylammo-, propylamino-, isopropylamino-, butylamino- and the tert-butylamino group, di-(Cj-Cg-alkyl)amino carries two of the same or different of the above named C] - Cg-alkyl groups on the nitrogen atom, especially in form of the dimethylamino-, diethylamino-, dipropylamino-, dnsopropylamino-, lsopropylmethylamino-, dibutylamino- or tert-butylmethylamino group, C j -Cg-acyl is the residue of an aliphatic saturated or unsaturated, straight chain, branched or cyclic carboxylic acid, especially in form of the formyl-, acetyl-, propionyl- , acryloyl-, butyryl-, lsobutyryl-, methacryloyl-, cyclopropylcarbonyl-, pentanoyl-, pivaloyl-, cyclobutylcarbonyl-, hexanoyl- and the dimethylacryloyl group, C j -Cg-alkansulfonyl is preferably the methanesulfonyl-, ethanesulfonyl-, propanesulfonyl-, butanesulfonyl-, pentanesulfonyl- and the hexanesulfonyl group, saturated five- to seven-membered heterocycles with one or two hetero-atoms are especially tetrahydrofuryl, tetrahydrothienyl, pyrrohdinyl, tetrahydropyranyl, Pipendinyl, hexahydroazepinyl, piperazinyl, hexahydrodiazepinyl or morphohnyl, monocyclic aromatic five- or six-membered heterocycles with one to three hetero¬ atoms are especially furyl, thienyl, pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, imidazolyl, pyrazolyl, oxadiazolyl, thiadiazolyl, tπazolyl, pyπdyl, pyrazinyl, pyπdazinyl, pyπmidinyl or tπazinyl, anellated bi- and tricyclic aromatic or partially hydrated carbocycic ring systems with 8 to 16 ring atoms and at least one aromatic ring are preferably benzocyclobutyl, indanyl, indenyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, biphenylenyl, fluorenyl, anthryl, dihydroanthryl, phenanthryl, dihydrophenanthryl, dibenzocycloheptenyl, dihydrodibenzocycloheptenyl, dihydrodibenzocyclooctenyl or tetrahydrodibenzocyclooctenyl, wherein mono- or dioxo-derivates, wherein, the residues of indanone, tetralone, anthrone, anthraquinone, fluorenone, phenanthrone, dibenzocycloheptenone, dihydrodibenzocycloheptenone or tetrahydrodibenzocyclooctenone are, for example, also to be understood as partially hydrated carbocychc ring systems, anellated bi- and tricyclische aromatic or partially hydrated heterocyclic ring systems with 8 to 16 ring atoms and at least one aromatic ring are, for example, lmidazothiazolyl, benzofuryl, dihydrobenzofuryl, benzothienyl, dihydrobenzothienyl, indolyl, indohnyl, benzimidazolyl, indazolyl, benzoxazolyl, benzisoxazolyl, benzo¬ thiazolyl, benzoisothiazolyl, benzofurazanyl, benzothiadiazolyl, benzotπazolyl, oxazolopyπdyl, thiazolopyπdyl, lsothiazolopyπdyl, lmidazopyπdyl, pyrazolopyπdyl, thienopyπmidinyl, chromanyl, benzopyranyl, quinolyl, isoquinolyl, dihydroquinolyl, tetrahydroquinolyl, benzodioxanyl, quinoxahnyl, quinazohnyl, naphthyπdinyl, carbazolyl, tetrahydrocarbazolyl, pyπdoindolyl, acπdinyl, phenothiazmyl, dihydrodibenzoxepinyl, benzocycloheptathienyl, dihydrothienobenzothiepinyl, dihydrodibenzothiepinyl, octahydrodibenzothiepinyl, dihydrodibenzazepinyl, octahydrodibenzazepinyl, benzocycloheptapyπdyl, dihydropyπdobenzodiazepmyl, dihydrodibenzoxazepinyl, dihydropyπdobenzoxepinyl, dihydropyπdobenzoxazepinyl, dihydrodibenzothiazepinyl or dihydropyπdobenzothiazepinyl, wherein their mono- or dioxo-derivates and/or optionally their possible tautomeres are also to be understood as partially hydrated heterocychc ring systems, for example, the residues of indolinone, isatin, benzoxazolone and/or their tautomeres hydroxybenzoxazol, of benzisoxazolone, benzothiazolone, benzoisothiazolone and benzimidazolone and/or their tautomeres, hydroxybenzisoxazol, hydroxybenzothiazol, hydroxybenzoisothiazol and hydroxybenzimidazol, of indazohnone, of oxazolopyπdinone, thiazolopyπdinones, pyrazolopyndinones and lmidazopyπdinones and/or their tautomeres hydroxyoxazolopyπdine, hydroxythiazolopyπdines, hydroxypyrazolopyπdines and hydroxyimidazopyπdines, the residues of chromanone, chromone, quinohnone, di- hydroquinohnone, tetrahydrocarbazolone, acπdone, of dihydrodibenzoxepinones, benzocycloheptathiophenones, dihydrothienobenzothiepinones, dihydrodibenzo- thiepinones, dihydrodibenzoazepinones, benzocycloheptapyπdinones, dihydropyπdo- benzoxazepinones, dihydrodibenzothiazepmones and of dihydropyπdobenzothiazepi- nones, saturated and unsaturated monocyclic, four- to eight-membered heterocycles are NR 13 R 15 as a grouping which, aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from N and/or S and/or O, for example azetidine, pyrrolidine, piperidine, (lH)tetrahydropyπdιne, hexahydroazepme, (lH)tetrahydroazepιne, octahydroazocine, pyrazolidine, piperazine, hexahydrodiazepine, morpholme, hexahydrooxazepine, thiomorphohne or thiomorphohne- 1 , 1 -dioxide, saturated or unsaturated bi- or tricyclic, anellated or bridged heterocycles with 8 to 16 ring atoms, represent NR 13 R 15 as a grouping which, aside from the essential nitrogen atom optionally contain one or two further hetero-atoms, selected from N and/or S and/or O, for example 5-aza-bιcyclo[2 1 l jhexane, 2-aza- bιcyclo[2 2 l ]heptane, 7-aza-bιcyclo[2 2 l]heptane, 2,5-dιaza-bιcyclo[2 2 l]heptane, 2- aza-bιcyclo[2 2 2]octane, 8-aza-bιcyclo[3 2 l]octane, 2,5-dιaza-bιcyclo[2 2 2]octane, 9-aza-bιcyclo[3 3 l]nonane, lndohne, isoindohne, (lH)-dιhydroquιnohne, (1H)- tetrahydroquinohne, (2H)-tetrahydroιsoquιnohne, (lH)-tetrahydroquιnoxahne, (4H)- dihydrobenzoxazine, (4H)-dιhydrobenothιazιne, (1 H)-tetrahydrobenzo[b]azepιne, (1 H)-tetrahydrobenzo[c]azepιne, (lH)-tetrahydrobenzo[d]azepιne, (5H)-tetrahydroben- zo[b]oxazepιne, (5H)-tetrahydrobenzo[b]thιazepιne, 1 ,2,3,4-tetrahydro-9H-pyπdo[3,4- b]ιndol, (l OH)-dιhydroacπdιne, 1 ,2,3,4-tetrahydroacπdanone, (lOH)-phenoxazιne, (l OH)-phenothιazιne, (5H)-dιbenzazepιne, (5H)-dιhydrodιbenzazepιne, (5H)- octahydrodibenzazepine, (5H)-dιhydrodιbenzodιazepιne, (11H)- dιhydrodιbenzo[b,e]oxazepιne, (1 lH)-dιhydrodιbenzo[b,e]thιazepιne, (lOH)-dιhydro- dιbenzo[b,f]oxazepιne, (10H)-dιhydrodιbenzo[b,f]thιazepιne or (5H)- tetrahydrodibenzazocine, as well as optionally possible tautomeres in the case of substitution of the heterocycle as such or in an anellated ring system by free hydroxy-, mercapto- and/or amino groups, and stereoisomers such as, if applicable, cis/trans-isomers, endo/exo-isomers, optic isomers such as enantiomers, diastereomers as pure isomers or mixtures and/or racemic mixtures as well as the pharmacologically acceptable acid addition salts with inorganic or organic acids, wherein the hydrochloπdes, hydrobromides, hydroiodides, sulfates and phosphates, are preferred as addition salts with suitable inorganic acids and acetates, benzoates, 4-methoxybenzoate, 2- or 4-hydroxybenzoate, 4-chlorobenzoate, ascorbate, sahcylate, formiate, glutarate, tπcarballylate, citrates, fumarates, gluconates, malates, maleates, methanesulfonates, lactates, oxalates, succinates, tartrates and toluolsulfonates, for example p-toluolsulfonate are preferred as addition salts of organic acids 4 Compounds according to one of the claims 1-3, characterized in that the substitutents labelled in formula (I) have the following meanings R is hydrogen, halogen, cyano, Ci -Cg-alkyl, tnfluoromethyl, C3-Cg-cycloalkyl, Cι -C4-hydroxyalkyl, hydroxy, Cι-C4-alkoxy, benzyloxy, C] -C4-alkanoyloxy, C]-C4-alkylthιo, C2-C5-alkoxycarbonyl, aminocarbonyl, C3-C9- dialkylaminocarbonyl, carboxy, phenyl, phenoxy, pyndyloxy or NR5R*>, wherein R 5 and R* > are selected independently from each other form hydrogen and C \ -Cg-alkyl, R 2 is hydrogen, halogen, C j -Cg-alkyl, trifluoromethyl or hydroxy, wherein R and R 2 , in the case they are adjacent, optionally form a bridge which are selected from the group of bridge members -(CH2)4- and -(CH=CH)2- and - CH 2 O-CR 7 R 8 -0-, wherein R 7 and R8 can be, independently from each other, hydrogen and C\ -Cg-alkyl, R 3 is selected from hydrogen, halogen and Ci -Cg-alkyl and R 4 is selected from hydrogen, C \ -Cg-alkyl, C3-Cg-alkenyl, hydroxy, C \ -Cg-alkoxy and benzyloxy, k is 0 or 1, A is selected from C\ -Cg-alkylene, which is optionally substituted once to three¬ fold by C]-C3-alkyl, hydroxy, fluorine or phenyl, 1 ,2-cyclopropylene, C2"Cg-alkylene, wherein a methylene unit can be isosterically replaced by O, S, NR^, CO, SO or SO2, and wherein the isosteric substitute, with the exception of =CO, cannot be adjacent to the amide group, and wherein R^ is hydrogen, C]-C3-alkyl, C ] -Cg-acyl or methanesulfonyl, D is selected from C]-CiQ-alkylene, which is optionally substituted once or twice by C] -C3-alkyl or hydroxy, C2-C] Q-alkenylene, optionally substituted once or twice by C1-C3 -alkyl or hydroxy, wherein the double bond can also be to ring E or C3-C 1 Q-alkinylene, which is optionally substituted once or twice by C1 -C3- alkyl or hydroxy, and can be selected as well from Ci -Cj o-alkylene, C2-C 1 Q-alkenylene or C3-CjQ-alkιnylene, in which one to three methylene units are isostencally replaced by O, S, NR*®, CO, SO or S0 , wherein R O has the same meaning as R^ , but is selected independently therefrom, (El) or (E2), wherein the heterocychc ring can optionally have a double bond and n and p can be, independent of each other, 0, 1, 2 or 3, with the proviso that n + p < 4, q is 2 or 3, RU is selected from hydrogen, Cι-C3-alkyl, hydroxy, hydroxymethyl, carboxy or C2-C7 -alkoxycarbonyl and R* 2 is selected from hydrogen or an oxo group adjacent to the nitrogen atom, G is selected from hydrogen, Gl, G2, G3, G4 and G5, wherein Gl represents the residue (CH 2 ) r (CR 14 R 15 ) S R 13 (Gl) wherein r is 0, 1 or 2 and s is 0 or 1, R* 3 is selected from hydrogen, C\ -Cg-alkyl, C3-Cg-alkenyl, C3-Cg-alkinyl, C3-C - cycloalkyl, benzyl, phenyl, monocyclic aromatic five- or six-membered heterocycles, which contain one to three hetero-atoms from the group N and/or S and/or O and are either bound directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated carbocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, whereby the bond can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricyclic aromatic or partially hydrated heterocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from the groups N and/or S and/or O and the bond can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, Rl 4 has the same meaning as R^ 3 , but is selected independently thereof, R 3 is selected from hydrogen, hydroxy, methyl, benzyl or phenyl, monocyclic aromatic five- or six-membered heterocycles, which can contain one to three hetero-atoms selected from the group N and/or S and/or O and are bound either directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated carbocychc ring systems with 8 to 16 ring atoms and at least einem aromatic ring, wherein the bond can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, anellated bi- and tricychc aromatic or partially hydrated heterocychc ring systems with 8 to 16 ring atoms and at least one aromatic ring, wherein one to three ring atoms can be selected from the group N and/or S and/or O and the bond can occur either over an aromatic or a hydrated ring and either directly or over a methylene group, G2 is selected from the residues C (CH 2 ). (CR 14 R 15 ) S R 13 ° (G2a) and C (CH 2 ) r NR 13 R 15 (G2b), wherein the substituents R* and R^ the can have the above meaning, or the group NR 13 R 15 can also be a nitrogen heterocycle bound over the nitrogen atom, selected from saturated or unsaturated monocyclic, four- to eight-membered heterocycles, which, aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from N and/or S and/or O, or saturated or unsaturated bi- or tricychc, anellated or bridged heterocycles with 8 to 16 ring atoms, which, aside from the essential nitrogen atom, can optionally contain one or two further hetero-atoms selected from N and/or S and/or O, G3 is the residue S0 2 (CH 2 ) r R 13 (G3), G4 is the residue \ p / Ar 1 O* \ Ar 2 (G4), wherein Ar and Ar 2 are selected independently of each other from phenyl, pyridyl or naphthyl, G5 is the residue COR 16 (G5) wherein Rl6 is trifluoromethyl, C ] -Cg-alkoxy, C3-Cg-alkenyloxy or benzyloxy and aromatic ring systems in which the substituents R , R 2 , R 4 , R^ 3 , R* 4 , R^, R!^, Ar^ and Ar 2 and/or in the ring system -NR 3 R l ^ can carry independently of each other one to three of the same or different substituents from the series halogen, cyano, C\ -Cg-alkyl, trifluoromethyl, C3-Cg-cycloalkyl, phenyl, benzyl, hydroxy, C ] -Cg-alkoxy, which is optionally entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, Ci -Cg-alkylthio, carboxy, C \ -Cg-alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, mono-C ] - Cg-alkylamino, di-(C] -Cg-alkyl)-amino, wherein two adjacent groups on the aromatic ring or ring system can form an additional ring over a methylenedioxy bridge. 5. Compounds according to one of the claims 1 -4, characterized in that the substiutents labelled in formula (I) (I) have the following meanings: R\ is hydrogen, halogen, cyano, methyl, trifluoromethyl, hydroxy, C i -C4-alkoxy, ethylthio, methoxycarbonyl, tert-butoxycarbonyl, aminocarbonyl, carboxy, and phenoxy, R 2 is hydrogen, halogen, trifluoromethyl or hydroxy, R 3 is hydrogen or halogen, R 4 is selected from hydrogen, C]-C3-alkyl, hydroxy and Ci -C3-alkoxy, k is 0 or 1, A is C2-Cg-alkylene, which is optionally substituted once or twice by C1-C3- alkyl, hydroxy or fluorine, as well as C2"Cg-alkylene, wherein a methylene unit can be isostencally replaced by O, S, CO or SO , and the isostenc substitute, with the exception of =CO cannot be adjacent to the amide group, is C\ -Cg-alkylene, which is optionally substituted once twice by methyl or hydroxy, C2'Cg-alkenylene, which is optionally substituted once or twice by methyl or hydroxy, wherein the double bond can also be to ring E, C3-Cg-alkιnylene, which is optionally substituted once or twice by methyl or hydroxy, as well as Cj -Cg-alkylene, C2-Cg-alkenylene or C3-Cg-alkιnylene, in which one to three methylene units can be isostencally replaced by O, S, NH, N(CH3), N(COCH 3 ), N(SO 2 CH 3 ), CO, SO or SO 2 , or (E2) wherein the heterocychc ring can optionally have a double bond and n and p can be, independent of each other, 0, 1 , 2 or 3, with the proviso that n + p < 3, q is 2 or 3, RU is selected from hydrogen, C]-C3-alkyl, hydroxy, hydroxymethyl and R* 2 is selected from hydrogen or an oxo group which is adjacent to the nitrogen atom, G is hydrogen or Gl, G2, G3, G4 and G5, wherein Gl represents the residue (CH 2 2 ) r r (CR 14 R 15 ) >s_ R 13 (G ] ) wherein r is 0, 1 or 2 and s is 0 or 1, is selected from hydrogen, C\ -Cg-alkyl, C3-Cg-cycloalkyl, benzyl or phenyl, benzocyclobutyl, indanyl, indenyl, oxoindanyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, oxotetrahydronaphthyl, biphenylenyl, fluorenyl, oxofluorenyl, anthryl, dihydroanthryl, oxodihydroanthryl, dioxodihydroanthryl, phenanthryl, dihydrophenanthryl, oxodihydrophenanthryl, dibenzocycloheptenyl, oxodibenzocycloheptenyl, dihydrodibenzocycloheptenyl, oxodihydrodibenzocycloheptenyl, dihydrodibenzocyclooctenyl, tetra- hydrodibenzocyclooctenyl and oxotetrahydrodibenzocyclooctenyl bound directly or over a methylene group, furyl, thienyl, pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, tπazolyl, pyridyl, pyrazinyl, pyπdazinyl, pyπmidmyl, tπazinyl, lmidazothiazolyl, benzofuryl, dihydrobenzofuryl, benzothienyl, dihydrobenzothienyl, mdolyl, indohnyl, oxoindohnyl, dioxoindohnyl, benzoxazolyl, oxobenzoxazohnyl, benzisoxazolyl, oxobenzisoxazohnyl, benzothiazolyl, oxobenzthiazohnyl, benzoisothiazolyl, oxobenzoisothiazolinyl, benzimidazolyl, oxobenzimidazohnyl, indazolyl, oxoindazohnyl, benzofurazanyl, benzothiadiazolyl, benzotπazolyl, oxazolopyπdyl, oxodihydrooxazolopyπdyl, thiazolopyπdyl, oxodihydrothiazolopyπdyl, lsothiazolopyndyl, lmidazopyπdyl, oxodihydroimidazopyπdyl, pyrazolopyπdyl, oxodihydropyrazolopyπdyl, thienopyπmidinyl, chromanyl, chromanonyl, benzopyranyl, chromonyl, quinolyl, isoquinolyl, dihydroqumolyl, oxodihydroquinohnyl, tetrahydroquinolyl, oxotetrahydroquinohnyl, benzodioxanyl, quinoxahnyl, quinazohnyl, naphthyπdinyl, carbazolyl, tetrahydrocarbazolyl, oxotetrahydrocarbazolyl, pyπdoindolyl, acπdinyl, oxodihydroacridinyl, phenothiazmyl, dihydrodibenzoxepinyl, oxodihydrodibenzoxepinyl, benzocycloheptathienyl, oxobenzocycloheptathienyl, dihydrothienobenzo- thiepinyl, oxodihydrothienobenzothiepinyl dihydrodibenzothiepinyl, oxodihydrodibenzothiepinyl, octahydrodibenzothiepinyl, dihydrodibenzazepinyl, oxodihydrodibenzazepinyl, octahydrodibenzazepinyl, benzocycloheptapyridyl, oxobenzocycloheptapyridyl, dihydropyπdo- benzodiazepinyl, dihydrodibenzoxazepinyl, dihydropyridobenzoxepinyl, dihydropyridobenzoxazepinyl, oxodihydropyridobenzoxazepinyl, dihydrodibenzothiazepinyl, oxodihydrodibenzothiazepinyl, dihydropyridobenzothiazepinyl, oxodihydropyridobenzothiazepinyl, bound directly or over a methylene group, Rl 4 has the same meaning as R 3 , but is selected independently therefrom, R!5 i s selected from hydrogen, hydroxy, methyl, benzyl or phenyl, indanyl, indenyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, furyl, thienyl, pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, pyridyl, pyrazinyl, pyridazinyl, pynmidinyl, triazinyl, benzofuryl, benzothienyl, indolyl, indohnyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, chromanyl, quinolyl or tetrahydroquinolyl bound directly or over a methylene group, G2 is selected from the residues C (CH 2 ) r (CR 14 R 15 ) S R 13 (G2a) and (G2b) wherein the substituents R* 3 and R* can have the above meanings, or represents the grouping each over the nitrogen-bound ring atom of azetidine, pyrrolidine, piperidine, (lH)tetrahydropyπdιne, hexahydroazepme, (lH)tetrahydroazepιne, octahydroazocine, pyrazolidine, piperazine, hexyhydrodiazepine, morpholme, hexahydrooxazepine, thiomorphohne, thiomorphohne- 1 ,1 -dioxide, 5-aza-bι- cyclo[2 1 l ]hexane, 2-aza-bιcyclo[2 2 l]heptane, 7-aza-bιcyclo[2 2 I jheptane, 2,5-dιaza-bιcyclo[2 2 Ijheptane, 2-aza-bιcyclo[2 2 2]octane, 8-aza-bιcyc- lo[3 2 l]octane, 2,5-dιazabιcyclo[2 2 2]octane, 9-azabιcyclo[3 3 ljnonane, lndohne, isoindohne, (lH)-dιhydroquιnohne, (lH)-tetrahydroquιnohne, (2H)- tetrahydroisoquinohne, (lH)-tetrahydroquιnoxahne, (4H)-dιhydrobenzoxazιne, (4H)-dιhydrobenzothιazιne, ( 1 H)-tetrahydrobenzo[b]azepme, ( 1 H)-tetrahydro- benzo[c]azepme, (lH)-tetrahydrobenzo[d]azepιne, (5H)- tetrahydrobenzo[b]oxazepιne, (5H)-tetrahydrobenzo[b]thιazepιne, 1 ,2,3,4- tetrahydro-9H-pyπdo[3,4-b]ιndole, (lOH)-dιhydroacπdιne, 1,2,3,4-tetrahydro- acπdanone, (lOH)-phenoxazιne, (lOH)-phenothιazιne, (5H)-dιbenzazepme, (5H)-dιhydrodιbenzazepιne, (5H)-Octahydrodιbenzazepιne, (5H)- dihydrodibenzodiazepine, (HH)-dιhydrodιbenzo[b,e]oxazepιne, (1 lH)-dιhydro- dιbenzo[b,e]thιazepιne, (10H)-dιhydrodιbenzo[b,f]oxazepιne, (10H)- dιhydrodιbenzo[b,f]thιazepιne or (5H)-tetrahydrodιbenzazocιne, G3 is the residue S0 2 (CH 2 ) r R 13 (G3), G4 is the residue \ p / Ar 1 (G ), wherein Ar* and Ar 2 are selected independently of each other from phenyl, pyridyl or naphthyl, G5 is the residue COR (G5) wherein Rl IS tnfluoromethyl, C\ -Cg-alkoxy, C3~Cg-alkenyloxy or benzyloxy and aromatic ring systems in which the substituents can be substituted independently of each other by one to three of the same or different substituents from the series halogen, cyano, C] -Cg-alkyl, tnfluoromethyl, C3-C - Cycloalkyl, phenyl, benzyl, hydroxy, C\ -Cg-alkoxy, C\ -Cg-alkoxy, which can be entirely or partially substituted by fluorine, can carry benzyloxy, phenoxy, mercapto, Ci -Cg-alkylthio, carboxy, Ci -Cg-alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, mono-Ci-Cg-alkylamino, dι-(C]-Cg-alkyl)- amino, wherein two adjacent groups in the ring or ring system can form an additional ring over a methylenedioxy bridge 6 Compounds according to one of the claims 1 -5, characterized in that the substituents labelled in formula (I) (I) have the following meaning: Rl is hydrogen, halogen, cyano, methyl, trifluoromethyl, hydroxy, methoxy or methoxycarbonyl, R 2 is hydrogen or halogen, R 3 is hydrogen, R 4 is selected from hydrogen, C1-C3 -alkyl or hydroxy, k is 0 or 1 , A is selected from C2-Cg-alkylene, which is optionally substituted once or twice by hydroxy or fluorine and C2-Cg-alkylene, wherein a methylene unit can be isosterically replaced by O, S or CO, and the isosteric substitute, with the exception of =CO, cannot be adjacent to the amide group and, D is C2-Cg-alkylene, which is optionally substituted by methyl or hydroxy C2-Cg-alkenylene, which is optionally substituted by methyl or hydroxy, wherein the double bond can also be to ring E, or G2"Cg-alkylene, C2-Cg-alkenylene, wherein one to three methylene units are isosterically replaced by O, NH, N(CH 3 ), N(COCH 3 ), N(S0 2 CH 3 ) or CO, E is selected from the residues (El) or (E2), wherein the heterocychc ring can optionally have a double bond and n and p can be, independent of each other, 0, 1, 2 or 3, with the proviso that n + p < 3 and q is 2 R Ϊ 1 is hydrogen, methyl or hydroxyl and R* 2 is hydrogen or an oxo group adjacent to the nitrogen atom, G is selected from hydrogen, C3-Cg-cycloalkyl, methoxycarbonyl, tert- butoxycarbonyl, benzyloxycarbonyl, tπfluoracetyl, diphenylphosphinoyl or the residues (CH 2 ) r (CR 14 R 15 ) S R 13 (Gl) and (CH 2 ). (CR 14 R 15 ) S R 13 (G2a) and and S0 2 (CH 2 ) r R 13 (G3) wherein s is 0 or 1, is hydrogen, methyl, benzyl or phenyl, indanyl, indenyl, oxoindanyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, oxotetrahydronaphthyl, fluorineenyl, oxofluorenyl, anthryl, dihydroanthryl, oxodihydroanthryl, dioxodihydroanthryl, dibenzocycloheptenyl, oxodibenzo¬ cycloheptenyl, dihydrodibenzocycloheptenyl, oxodihydrodibenzocycloheptenyl bound directly or over a methylene group, furyl, thienyl, pyrrolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, tπazolyl, pyπdyl, pyrazinyl, pyπdazinyl, pynmidinyl, lmidazothiazolyl, benzofuryl, dihydrobenzofuryl, benzothienyl, dihydrobenzothienyl, dolyl, indohnyl, oxoindohnyl, dioxoindohnyl, benzoxazolyl, oxobenzoxazohnyl, benzisoxazolyl, oxobenzisoxazohnyl, benzothiazolyl, oxobenzthiazohnyl, benzoisothiazolyl, oxobenzoisothiazolinyl, benzimidazolyl, oxobenzimtdazohnyl, benzofurazanyl, benzothiadiazolyl, benzotπazolyl, oxazolopyπdyl, oxodihydrooxazolopyπdyl, thiazolopyπdyl, oxodihydrothiazolopyπdyl, isothiazolopyπdyl, lmidazopyπdyl, oxodihydro- lmidazopyπdyl, pyrazolopyπdyl, thienopyπmidinyl, chromanyl, chromanonyl, benzopyranyl, chromonyl, quinolyl, isoquinolyl, dihydroquinolyl, oxodihydroquinohnyl, tetrahydroquinolyl, oxotetrahydroquinohnyl, benzodioxanyl, quinoxahnyl, quinazohnyl, naphthyπdinyl, carbazolyl, tetrahydrocarbazolyl, oxotetrahydrocarbazolyl, pyπdomdolyl, acπdmyl, oxodihydroacridinyl, phenothiazmyl, dihydrodibenzoxepinyl, benzocyclohepta- thienyl, oxobenzocycloheptathienyl, dihydrothienobenzothiepinyl, oxodihydro- thienobenzothiepinyl dihydrodibenzothiepinyl, oxodihydrodibenzothiepinyl, dihydrodibenzazepinyl, oxodihydrodibenzazepmyl, octahydrodibenzazepinyl, benzocycloheptapyπdyl, oxobenzocycloheptapyndyl, dihydropyπdobenzoxepinyl, dihydrodibenzothiazepinyl, oxodihydrodibenzothiazepinyl bound directly or over a methylene group, R l 4 is hydrogen, methyl, benzyl or phenyl, Rl* is selected from hydrogen, hydroxy, methyl, benzyl, phenyl, naphthyl, furyl, thienyl, oxazolyl, thiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, pyridyl, benzofuryl, benzothienyl, mdolyl, indohnyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, chromanyl, quinolyl or tetrahydroquinolyl, bound directly or over a methylene group, wherein in formula (I) C (CH 2 ) r NR 13 R 15 0 (G2b) the group NR' 3 R ' 5 can also be selected from pyrrolidine, piperidine, (lH)tetrahydropyπdιne, hexahydroazepme, Octahydroazocine, piperazine, hexa- hydrodiazepine, morpholme, hexahydrooxazepine, 2-azabιcyclo[2 2 l jheptane, 7-azabιcyclo[2 2 l]heptane, 2,5-dιazabιcyclo[2 2 l]heptane, 8- azabιcyclo[3 2 l]octane, 2,5-dιazabιcyclo[2 2 2]octane, indohne, isoindoline, (lH)-dιhydroquιnolme, (lH)-tetrahydroquιnohne, (2H)-tetrahydroιsoqumohne, (l H)-tetrahydroquιnoxahne, (4H)-dιhydrobenzoxazιne, (4H)- dihydrobenzothiazine, (lH)-tetrahydrobenzo[b]azepιne, (lH)-tetrahydroben- zo[d]azepιne, (5H)-tetrahydrobenzo[b]oxazepιne, (5H)- tetrahydrobenzo[b]thιazepme, l,2,3,4-tetrahydro-9H-pyπdo[3,4-b]ιndol, (10H)- dihydroacπdine, 1 ,2,3,4-tetrahydroacπdanone, (5H)-dιhydrodιbenzazepιne, (5H)-dιhydrodιbenzodιazepιne, (1 lH)-dιhydrodιbenzo[b,e]oxazepme, (1 1H)- dιhydrodιbenzo[b,e]thιazepme, (10H)-dιhydrodιbenzo[b,f]oxaze-pιne or (5H)- tetrahydrodibenzazocine 7 Compounds according to one of the claims 1-6, characterized in that the substituents labelled in the formula (I) (I) have the following meanings: Rl is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl or hydroxy, R 2 and R 3 are hydrogen, R 4 is hydrogen or hydroxy, k is 0 or 1, A is selected from C2-Cg-alkylene, which is optionally substitued once or twice by hydroxy or fluorine, D is selected from C2-Cg-alkylene, C2-Cg-alkenylene, wherein the double bond can also be to ring E, and C2-Cg-alkylene and C2-Cg-alkenylene, wherein a methylene unit can be isosterically replaced by O, NH, N(CH3) or CO or an ethylene group can be isosterically replaced by NH-CO and/or CO-NH or a propylene group can be isosterically replaced by NH-CO-O and/or O-CO-NH, E is selected from pyrrolidine, piperidine, 1 ,2,5,6-tetrahydropyridine, hexahydroazepme, morpholine and hexahydro-l ,4-oxazepine, wherein the heterocychc ring optionally adjacent to the nitrogen atom, can be substituted by an oxo group, G is selected from hydrogen, tert-butoxycarbonyl, diphenylphosphinoyl, or one of the residues (CH 2 ) r (CR 14 R 15 ) S - >13 (Gl) and C (CH 2 ) r (CR 14 R 15 )_ R 13 II O (G2a) and (G2b) and S0 2 (CH 2 ) r R 13 (G3) wherein is 0 or 1 and is 0 or 1 , Rl 3 is hydrogen, methyl, benzyl or phenyl, indenyl, oxoindanyl, naphthyl, tetrahydronaphthyl, fluorenyl, oxofluorenyl, anthryl, dihydroanthryl, oxodihydroanthryl, dioxodihydroanthryl, dibenzocycloheptenyl, dihydrodibenzocycloheptenyl bound directly or over a methylene group, furyl, thienyl, oxazolyl, thiazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, pyridyl, pyrazinyl, pyrimidinyl, imidazothiazolyi, benzofuryl, benzothienyl, mdolyl, oxoindohnyl, dioxoindolinyl, benzoxazolyl, oxobenzoxazolmyl, benzothiazolyl, oxobenzthiazohnyl, benzimidazolyl, oxobenzimidazohnyl, benzofurazanyl, benzotπazolyl, oxazoiopyridyl, oxodihydrooxazolopyridyl, thiazolopyπdyl, oxodihydrothiazolopyπdyl, chromanyl, chromanonyl, benzopyranyl, chromonyl, quinolyl, isoquinolyl, oxodihydroquinohnyl, tetrahydroquinolyl, oxotetrahydro- quinohnyl, benzodioxanyl, quinazolinyl, acridinyl, oxodihydroacridinyl, phenothiazmyl, dihydrodibenzoxepinyl, benzocycloheptathienyl, dihydro- thienobenzothiepinyl, dihydrodibenzothiepinyl, oxodihydrodibenzothiepinyl, dihydrodibenzazepinyl, oxodihydrodibenzazepmyl, octahydrodibenzazepinyl, benzocycloheptapyndyl, oxobenzocycloheptapyndyl, dihydrodibenzothiazepinyl bound directly or over a methylene group, is hydrogen, methyl, benzyl or phenyl, 1S hydrogen, hydroxy, methyl, benzyl or phenyl, naphthyl, furyl, thienyl, pyridyl, benzofuryl, benzothienyl, mdolyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, chromanyl, quinolyl or tetrahydroquinolyl bound directly or over a methylene group, wherein in the formula C (CH 2 ) r NR 13 R 15 (G2b) the group NR 13 R 15 can be selected from pyrrolidine, piperidine, hexahydroazepme, morpholme, 2,5-dιazabιcyclo[2 2 I jheptane, indoline, isoindoline, (lH)-dιhydroquιnohne, (l H)-tetrahydroquιnohne, (2H)-tetrahydro- lsoquinohne, (1 H)-tetrahydrobenzo[b]azepιne, (1 H)-tetrahydrobenzo[d]azepιne, (5H)-tetrahydrobenzo[b]oxazepιne, (5H)-tetrahydrobenzo[b]thιazepιne, 1,2,3,4- tetrahydroacπdanone, (5H)-dιhydrodιbenzazepιne, (1 l H)-dιhydrodιbenzo[b,e]- oxazepine or (1 lH)-dιhydrodιbenzo[b,e]thιazepιne and wherein aromatic ring systems in the substituents can be substituted, independently of each other, by one to three of the same or different substituents from the series halogen, cyano, C ] -Cg-alkyl, trifluoromethyl, C3-Cg-cycloalkyl, phenyl, benzyl, hydroxy, C\ -Cg-alkoxy, C 1 -Cg-alkoxy, which can be entirely or partially substituted by fluorine, can carry benzyloxy, phenoxy, mercapto, C ] - Cg-alkylthio, carboxy, C j -Cg-alkoxycarbonyl, benzyloxycarbonyl, nitro, ammo, mono-Cι-Cg-alkylamιno or dι-(C] -Cg-alkyl)-amιno, whereby two adjacent groups on the aromatic ring or ring system for an additional ring over a methylenedioxy bridge 8 Compounds according to one of the claims 1 -7, characterized in that the substituents labelled in the formula (I) (i) have the following meanings Rl IS hydrogen, fluorine, methyl, trifluoromethyl or hydroxy, R 2 and R 3 are hydrogen, R 4 is hydrogen or hydroxy, k is O, A is selected from ethylene, propylene or butylene optionally substituted by hydroxy or one or two fluorine, or D is selected from C2-Cg-alkylene or C2-Cg-alkenylene, wherein the double bond E is selected from pyrrolidine, piperidine, hexahydroazepme or morpholme, G is selected from benzyl, phenethyl, fluorenylmethyl, anthrylmethyl, diphenylmethyl, fluorenyl or dihydrodibenzocycloheptenyl, furyimethyl, thienylmethyl, thiazolylmethyl, pyndylmethyl, benzothienylmethyl, quinolylmethyl, phenyl-thienylmethyl, phenyl-pyπdylmethyl, dihydrodibenzoxepinyl, dihydrodibenzothiepinyl, acetyl, pivaloyl, phenylacetyl, diphenylacetyl, diphenylpropionyl, naphthylacetyl, benzoyl, naphthoyl, anthrylcarbonyl, oxofluorenylcarbonyl, oxodihydro- anthrylcarbonyl or dioxodihydroanthrylcarbonyl, furoyl, pyπdylcarbonyl, chromonylcarbonyl, quinolylcarbonyl, naphthylaminocarbonyl, dibenzylaminocarbonyl, benzylphenylaminocarbonyl, diphenylaminocarbonyl, indohnyl- 1 -carbonyl, dihydrodibenzazepin-N-carbonyl, tetrahydroquinohnyl-N-carbonyl, tetrahydrobenzo[b]azepιnyl-N-carbonyl, methanesulfonyl, phenylsulfonyl, p-toluolsulfonyl, naphthyl sulfonyl, quinohnsulfonyl and diphenylphosphinoyl, wherein aromatic ring systems can be substituted independently of each other by one to three of the same or different substituents from the series halogen, cyano, C] -Cg-alkyl, tnfluoromethyl, C3-Cg-cycloalkyl, phenyl, benzyl, hydroxy, C ] -Cg-alkoxy, C \ -Cg-alkoxy, which can be entirely or partially substituted by fluorine, benzyloxy, phenoxy, mercapto, C]-Cg-alkylthιo, carboxy, Cj -Cg-alkoxycarbonyl, benzyloxycarbonyl, nitro, amino, mono-Ci - Cg-alkylamino or dι-(Cι-Cg-alkyl)-amιno, wherein two adjacent groups in the ring or ring system can form an additional ring over a methylendioxy bridge 9 Compound according to one of the claims 1-8, characterized in that it is present in the form of N-[4-(l-acetyl-pιpeπdιn-4-yl)-butyl]-3-(pyπdιn-3-yl)-propιonamιde, N-[4-(l-benzoyl-pιpeπdιn-4-yl)-butyl]-3-(pyπdιn-3-yl)-propιonamιde, N-[4-(l -dιphenylacetyl-pιpeπdιn-4-yl)-butyl]-3-(pyπdιn-3-yl)-propιonamιde, N-{4-[l-(9-oxo-9H-fluoren-4-carbonyl)-pιpeπdιn-4-yl]-butyl}-3-(pyπdιn-3-yl)- propionamide, N-[4-(l-methylsulfonyl-pιperidιn-4-yl)-butyl]-3-(pyπdιn-3-yl)-propιonamιde or N-{4-[l-(2-naphthylsulfonyl)-pιperidιn-4-yl]-butyl}-3-(pyrιdιn-3-yl)-propιonamιde, and/or as a pharmaceutically acceptable acid addition salt thereof 10 Compound according to one of the claims 1-8, characterized in that it is present in the form of N-[4-(l -benzylpιpeπdιn-4-yl)-butyl]-3-(pyπdin-3-yl)-propιonamιde, N-(4-{ l-[bιs-(2-chlorophenyl)-methyl]-pιperidιn-4-yl}-butyl)-3-(pyπdιn-3-yl)- propionamide, N-{4-[l -(phenylpyπdιn-3-yl-methyl)-pιpeπdιn-4-yl]-butyl}-3-(pyπdιn-3-yl)- propionamide, N-{4-[l-(9H-fluoren-9-yl)-pιperidιn-4-yl]-butyl}-3-(pyπdιn-3-yl)-propιonamιde or N-{4-[l-(6,l l-dιhydrodιbenzo[b,e]oxepιn-l l-yl)-pιpeπdιn-4-yl]-butyl}-3-(pyπdιn-3- yl)-propιonamιde, and/or as a pharmaceutically acceptable acid addition salt thereof 1 1 Compound according to one of the claims 1-8, characterized in that it is present in the form of N-{4-[l-(l-naphthylamιnocarbonyl)-pιpeπdιn-4-yl]-butyl}-3-(pyπdιn-3-yl)- propionamide, N-[4-(l-dιphenylamιnocarbonyl-pιperidιn-4-yl)-butyl]-3-(pyπdιn-3-yl)-propιonamιde, N-{4-[l -(10,l l -dιhydrodιbenzo[b,f]azepιn-5-yl-carbonyl)-pιpeπdιn-4-yl]-butyl}-3- (pyπdιn-3-yl)-propιonamιde or N-[4-(l -dιphenylphosphιnoyl-pιperιdιn-4-yl)-butyl]-3-(pyπdιn-3-yl)-propιonamιde, and/or as a pharmaceutically acceptable acid addition salt thereof 12 Compound according to one of the claims 1-8, characterized in that it is present in the form of N-[4-(l-dιphenylmethyl-pιpeπdιn-4-yl)-butyl]-3-(2-fluorpyπdιn-3-yl)-propιonamιde, N-[4-(l-dιphenylmethyl-pιpeπdιn-4-yl)-butyl]-3-(5-fluorpyπdιn-3-yl)-propιonamιde, N-[4-(l-dιphenylmethyl-pιpeπdιn-4-yl)-butyl]-2-fluor-3-(pyπdιn-3-yl)-propιonamιde or N-[4-(l-dιphenylmethyl-pιpeπdιn-4-yl)-butyl]-2,2-dιfluor-3-(pyπdιn-3-yl)- propionamide, and/or as a pharmaceutically acceptable acid addition salt thereof 13 Compound according to one of the claims 1-8, characterized in that it is present N-[5-(l-dιphenylmethyl-pιpeπdιn-4-yl)-pentyl]-3-(pyπdιn-3-yl)-propιonamιde, N-[6-(l-dιphenylmethyl-pιpeπdιn-4-yl)-hexyl]-3-(pyπdιn-3-yl)-propιonamιde, N-[2-(l-dιphenylmethyl-pιpeπdιn-4-yl)-ethyl]-5-(pyπdιn-3-yl)-pentanoιc acid amide or N-[4-(l-dιphenylmethyl-pιpeπdιn-4-yl)-butyl]-3-(pyπdιn-3-yl)-propιonamιde, N-[4-( 1 -dιphenylmethyl-pιperιdιn-4-yl)-butyl]-5-(pyπdιn-3-yl)-pentanoιc acid amide, and/or as a pharmaceutically acceptable acid addition salt thereof 14 Compound according to one of the claims 1-8, characterized in that it is present in the form of N-[4-(l -dιphenylmethylpιpeπdm-4-yl)-butyl]-N-hydroxy-3-(pyπdιn-3-yl)- propionamide, N-[4-(l -dιphenylmethylpιpeπdιn-4-yl)-butyl]-2-hydroxy-3-(pyπdιn-3-yl)-propιonamιde or N-[4-(l -dιphenylmethyl-pιpeπdιn-4-yl)-butyl]-3-hydroxy-3-(pyπdιn-3-yl)- prop ion amide and/or as a pharmaceutically acceptable acid addition salt thereof 15 Method for the production of compounds according to formula (I) according to one of the claims 1-14 characterized in that either (a) carboxylic acids of formula (II) ( ° ) k (ii) in which R*, R 2 , R^, A and k have the meaning given above or their reactive derivatives are reacted with compounds of formula (III) H N D E G I (III) wherein D, E, G and R 4 have the meanings given in claims 1 -8 or (b) compounds of formula (I), wherein G is hydrogen, are reacted with a compound of formula (IV), (IV) in which G has the meaning given in claims 1-8, with the exception of hydrogen, and L represents a suitable nucleofuge or reactive group, whereby the type of specific nucleofuge or reactive group L as well as the reaction conditions are or dent on the nature of the residue G, or (c) compounds of formula (I), in which G has the meaning of Gl ac g to claims 1-7, with the exception of hydrogen, are produced in a such a manner mat compounds of formula (I), in which G is hydrogen, are reacted with a suitable alkylation agent and/or arylation agent of formula (IV) according to the above variant wherein G is an alkyl-, alkenyl-, alkinyl-, cycloalkyl-, aryl-, aralkyl-, heteroaryl- leteroaralkyl residue according to definition and the nucleofuge L can be a reactive ueπvative of an alkohol, for example, a halogen atom such as chlorine, bromine or iodine or a sulfonic acid ester, l e for example a methanesulfonyloxy-, tπfluoromethanesulfonyloxy-, ethanesulfonyloxy-, benzenesulfonyloxy-, p-toluenesulfonyloxy-, p- bromobenzenesulfonyloxy- or m-mtrobenzenesulfonyloxy residue, etc or a reactive group L can be an epoxide group, (d) compounds of formula (I), in which G represents an acyl, carbamoyl, sulfonyl or a phosphinoyl residue according to the above definition are produced in such a manner that compounds of formula (I), in which G is hydrogen, are reacted with a carboxylic, carbamic, sulfonic and/or phosphinic acid of formula (V), HO (V) wherein G is an acyl, carbamoyl, sulfonyl or phosphinoyl residue according to definition, or with derivatives thereof capable of reaction, whereby symmetric or unsymmetπc carboxylic acid anhydrides and/or sulfonic acid anhydrides or acyl- and/or sulfonyl halides, especially acyl- and/or sulfonyl chlorides and carbamoyl halides and/or phosphinic acids are used as preferred derivatives of carboxylic acids and/or sulfonic acids (V) capable of reaction, and the reaction of the acids (V) and/or their reactive derivatives with the compounds (I), in which G is hydrogen, preferably occurs in the presence of auxiliary bases in solvents and under conditions as they are described in variant (a), or (e) compounds of formula (I), in which G represents a carbamoyl residue according to the definition (G2b) in the form of the grouping — C— (CH 2 )— NR 13 R 15 II r O wherein r = 0 are produced in such a manner that compounds of formula (I), in which G is hydrogen are reacted with a carbonyl group transmitter to an intermediate product and the latter, without its purification or previous isolation, is brought to reaction with a primary or secondary amine with the formula (VI) H-NR 13 R 15 (VI) wherein R^ 3 and R 5 and/or the grouping ^R R nave tne meanings according to claims 1-7, wherein bιs-(tπchloromethyl) carbonate (tnphosgene) and carbonyldiimidazol are used as particularly reactive carbonyl group transmitters and the reaction of compounds of formula (I), wherein G is hydrogen, with tnphosgene and/or carbonyldiimidazol is preferably carried out in an absolute, inert solvent in the presence of a tertiary organic amme as an auxiliary base in such a manner that the solution of compounds (I) and the auxiliary base are slowly added to a solution of an equivalent amount of carbonyl group transmitter, or (f) compounds of formula (I), in which G is a carbamoyl residue according to the definition G2, with r = 0 and R* 5 = hydrogen, with grouping — C-NHR 13 R 15 II 0 are produced in such a manner that compounds of formula (I), in which G is hydrogen, are brought into reaction with an isocyanate of the formula (VII) 0=C=N-R 13 (vπ) in which Rl 3 has the meaning as given in claims 1-7, wherein the reaction of the compounds of formula (I), in which G is hydrogen, with the lsocyanates of formula (VII) preferably occurs in an absolute, inert solvent, such as for example, a hydrocarbon such as pentane, hexane, heptane, benzene, toluene, or xylene, chlorinated hydrocarbons (such as dichloromethane, chloroform, 1,2-dιchloroethane, tnchloroethylene), ethers (for example, diethyl ether, tetrahydrofuran, dioxane), esters such as ethyl acetate, butyl acetate, or polar aprotic solvents such as formamide or dimethylformamide and/or mixtures thereof and the reaction temperatures can he in the region from -20°C to 150°C, but can preferably vary from 20°C to 100°C, or (g) compounds of formula (I), m which R 4 is an alkyl, alkenyl, alkinyl or cycloalkyl residue according to the above definition are produced in such a manner that compounds of the formula (I), in which R 4 is hydrogen, are reacted with a suitable alkylation agent of formula (VIII) R< (VIII) in which R 4 is an alkyl, alkenyl, alkinyl or cycloalkyl residue according to definition and L represents a suitable nucleofuge, 1 e for example a halogen atom such as chlorine, bromine or iodine or a sulfonic acid ester of an alcohol, wherein sulfonic acid esters of formula (VIII) especially contain a methylsulfonyloxy group, tnfluoromethanesulfonyloxy-, p-toluenesulfonyloxy-, p-bromobenzenesulfonyloxy- or m-mtrobenzenesulfonyloxy residue as a nucleotype L and the amide alkylation is carried out in the presence of tertiary amino groups under the use of strong auxiliary bases such as potassium tert-butyl ate, sodium hydride, potassium hydride or butyl lithium in aprotic, inert solvents, for example, aliphatic or aromatic hydrocarbons such as pentane, hexane, heptane, benzene, toluene or ethers such as tetrahydrofuran, dioxane, or poral solvents such as dimethylsulfoxide, dimethylformamide, N- methylpyrrohdone, wherein the reaction temperature can he between -40°C and 140°C, preferably between -20°C and 80°C, depending on the reactivity of the educts 16 Method according to claim 15, characterized in that as reactive derivatives of compound (II) their activated esters, anhydrides, acid halides, (especially acid chlorides), simple low alkyl esters, espcially the p-nitrophenyl esters 2,4,6- tπchlorophenyl esters, pentachlorophenyl esters, cyanomethyl esters, esters of N- hydroxysuccimmide, N-hydroxyphthahmide, 1 -hydroxybenzotπazol, N- hydroxypipeπdine, 2-hydroxypyπdιne or 2-mercaptopyπdιne are used according to method variant (a), wherein symmetric as well as mixed anhydrides or for example those from the reaction with pivolyl chloride or with chloroformates, for example, aromatic chloroformates such as chloroformic acid phenyl ester, araliphatic chloroformates such as chloroformic acid benzyl ester or aliphatic chloroformates such as chloroformic acid methyl ester, ethyl ester or isobutyl ester are used as anhydrides, and the reaction of the compounds (II) with the compounds (III) can be facultatively preformed in the presence of condensation agents such as dicyclohexylcarbodimide, 1 - ethyl-3-(3-dιmethylamιnopropyl)-carbodnmιde hydrochloride, N,N'-carbonyldnmιdazol or l -ethoxycarbonyl-2-ethoxy-l,2-dιhydroquιnohne, wherein in the case of carbodiimides as a condensation agent, especially N- hydroxysuccinimide, N-hydroxyphthahmide, 1-hydroxybenzotπazol or N- hydroxypipeπdine can be added, and the compounds of formula (HI) as free bases as well as in form of their acid addition salts can be brought to reaction, especially in form of salts of organic acids such as hydrochloπdes, hydrobromides, or sulfates and the reaction of compounds of formula (II), optionally in form of their reactive derivatives, is performed with compounds (III) in a suitable, preferably inert, solvent such as aromatic hydrocarbons such as benzene, toluene, xylene, halogenated hydrocarbons such as dichloromethane, chloroform, 1 ,2- dichloroethane, tnchloroethylene, or ethers such as diethyl ether, tetrahydrofuran, dioxane, glycol dimethyl ether, ethylacetate, acetonitrile or polar aprotic solvents such as dimethylsulfoxide, dimethylformamide or N-methylpyrrohldone as such in pure form or as mixtures of two or more thereof, wherein the reaction is optionally carried out in the presence of an auxiliary base such as alkali metal carbonates, for example sodium carbonate, potassium carbonate, alkali metal hydrogen carbonates such as sodium hydrogen carbonate, potassium hydrogen carbonate, or organic bases such as triethylamine, ethyldusopropylamine, tnbutylamine, N-methylmorphohne or pydrid e, wherein a suitable excess of the compound of formula (III) can be used as a base, and in case of use of the compounds of formula (III) in form of their acid addition salts, the amount of the auxiliary base is considered equivalent, and the reaction temperatures preferably he between -40°C and 180°C, especially between -10°C and 130°C, preferably at the boiling point of the solvent used 17 Method according to claim 15, characterized in that according to method variant (b), the reaction of compounds (I), in which G is hydrogen, with compounds according to formula (IV) can be carried out in an inert solvent such as aromatic hydrocarbons for example, benzene, toluene, xylene, or ethers, for example, in tetrahydrofuran, dioxane, glycol dimethyl ether, or in ethylacetate, acetonitrile, ketones such as acetone, ethyl methyl ketone, in polar protic solvents such as alcohols such as ethanol, isopropanol, butanol, glycol monomethyl ether or polar aprotic solvents such as dimethylsulfoxide, dimethylformamide or N-methylpyrrohdone, wherein pure solvent as well as mixtures of two or more of them can be used, and the reactions can be carried out in the presence of bases, for example in the presence of the same as they can be used according to the method variant (a) according to claim 15, and, in the case of the chlorides or bromides as compounds (IV), addition of alkali metal iodides such as sodium iodide or potassium iodide occurs and the reaction temperatures can vary between 0°C and 180°C, however, preferably between 20°C and 130°C, depending on the reactivity of the educts 18 Compounds according to the general formula (I) (I) wherein G is hydrogen and the remaining substituents have the meanings given in the claims 1 -7 19 Compound or compound mixture according to one of the claims 1 -14 and 18 for use in a therapeutic method for treatment of the human or animal body or in a corresponding diagnosis method 20 Compound or compound mixture for use in a therapeutic method according to claim 19, characterized in that the therapeutic use is in connection with cancerostatic or cytostatic or immunosuppressive treatment, and/or preventing metastasis formation optionally in connection with suitable pharmaceutically acceptable adjuvants and carriers and/or one or more further active ingredients 21 Use of one or more compounds according to one of the claims 1-14 and 18 for the production of a medicament for the treatment of the human or animal body in the medical indications named above in claim 20 22 Medicament with an amount of one or more active ingredients according to one or more of the claims 1-14 and 18, optionally in connection with a pharmaceutically acceptable carrier, aside from toxicologically safe adjuvants, and/or in combination with other active ingredients 23 Method for the production of a medicament according to claim 22, characterized in that one or more of the compounds according to one or more of the claims 1 -14 and 18 are processed with suitable, pharmaceutically acceptable carriers and adjuvants to a finished medical form 24 Medicament according to claim 22, characterized in that it is present in the form of a solid, peroral administration form as a tablet, capsule, coated tablet, optionally in sustained action or gastric fluid-resistant form, or as a liquid, peroral administration solution, suspension, effervescent tablet, in the form of tabs or sachets, optionally in sustained action, if possible, or in gastric fluid-resistant form 25 Medicament according to claim 22, characterized in that it is present in the form of a suitable injection or infusion preparation together with suitable pharmaceutically acceptable carriers and adjuvants, optionally in sustained action form or as a parenteral depot medicinal form or implant or is used in the form of a concentrate, powder or lyophihsate and the parenteral dilution agent is optionally manufactured in the packaging separately therefrom, wherein the mixing of both compounds with each other or of the active ingredient with a common parenterally applicable dilution agent occurs immediately before use 26 Medicament according to claim 22, characterized in that it is present in the form of an inhalation therapeutic agent, for example, in the form of a spray together with suitable pharmaceutically acceptable propellants, carriers and adjuvents 27 Medicament according to claim 22, characterized in that it is present in the form of a transdermal therapeutic system for systemic treatment 28 Medicament according to claim 22, characterized in that it is present in the form of a gastrointestinal therapeutic system for systemic treatment 29 Medicament according to claim 22, characterized in that it is present in the form of a salve, suspension, emulsion, a balm or plaster or in the form of an externally applicable solution 30 Medicament according to claim 26 for administration by means of a controlled dosage aerosol or in the form of a dry powder dosage formulation 31 Medicament according to claim 22, characterized in that it is present in the form of a rectal, genital, or transurethral administration emulsion, a solution, a hposomal solution, an implant, suppository or a capsule 32 Medicament according to claim 22, characterized in that it is present in the form of a nasal, otologic or ophthalmologic composition 33 Medicament according to one of the claims 22 or 24, characterized in that it is present in the form of a buccally applicable form 34 Medicament according to one of the claims 22 and 24, characterized in that a dosage unit for single administration contains 0 01 to 2 0 mg or 0 1 -10 or 20 mg active ingredient according to the claims 1-14 and 18 35 Medicament according to claim 26, characterized in that the pharmaceutically acceptable carrier and/or diluent is a propellant aerosol 36 Medicament according to claim 26 or 35, characterized in that the propellant aerosol is tetrafluoroethane and/or heptafluoropropane and/or propane, butane, or dimethyl ether or mixtures thereof 37 Medicament according to one of the claims 26, 35 or 36, characterized in that the propellant aerosol contains surface active adjuvants 38 Medicament according to one of the claims 22 or 26, characterized in that it contains glucose and/or lactose as a dry powder dosage 39 Substance or substance mixture according to one of the claims 19 or 20, characterized in that the therapeutic use is suitable in connection with the combination with a further cytostatic agent or immunosuppressive agent 40 Medicament according to one of the claims 22 and 24, characterized in that it is present in combination with a further cytostatic agent or immunosuppressive agent, optionally in the form of separate dosage units in the pharmaceutical package

Inventors: BIEDERMANN ELFI, HASMANN MAX, LOESER ROLAND, RATTEL BENNO, REITER FRIEDEMANN, SCHEIN BARBARA, SEIBEL KLAUS, VOGT KLAUS, BIEDERMANN, ELFI, HASMANN, MAX, LOESER, ROLAND, RATTEL, BENNO, REITER, FRIEDEMANN, SCHEIN, BARBARA, SEIBEL, KLAUS, VOGT, KLAUS
Applicants: BIEDERMANN ELFI, HASMANN MAX, KLINGE CO CHEM PHARM FAB, LOESER ROLAND, RATTEL BENNO, REITER FRIEDEMANN, SCHEIN BARBARA, SEIBEL KLAUS, VOGT KLAUS, BIEDERMANN, ELFI, HASMANN, MAX, KLINGE PHARMA GMBH, LOESER, ROLAND, RATTEL, BENNO, REITER, FRIEDEMANN, SCHEIN, BARBARA, SEIBEL, KLAUS, VOGT, KLAUS
Application year: 1997
Main classification: C07D401
IPC codes: A61K31, A61P35, A61P37, C07D401, C07D405, C07D409, C07D413, C07D417, C07D471, C07D491, C07D493, C07D495, C07D513, C07F9