BICYCLIC PYRIMIDINE DERIVATIVES AND THEIR USE AS ANTI-COAGULANTS

Abstract: This invention is directed to bicyclic pyrimidine derivatives which are useful as anti-coagulants, of formulae (I) and (II), wherein A is -O-, -N(R<5>)-, or -S(O)n- (where n is 0, 1 or 2); Z<1> and Z<2> are independently -O-, -N(R<5>)- or -OCH2-. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.

Description: BICYCLIC PYRIMIDINE DERIVATIVES AND THEIR USE AS ANTI-COAGULANTS Field of the Invention The present invention is directed to bicyc c pyπmidine derivatives and their pharmaceutically acceptable salts, which inhibit the enzyme, factor Xa, thereby being useful as anti-coagulants It also relates to pharmaceutical compositions containing the derivatives or their pharmaceutically acceptable salts, and methods of their use. BACKGROUND OF THE INVENTION Factor Xa is a member of the trypsiπ-like senne protease class of enzymes A one-to-one binding of factors Xa and Va with calcium ions and phospholipid forms the prothrombinase complex which converts prothrombin to thrombin Thrombin , in turn, converts fibπnogen to fibrin which polymerizes to form insoluble fibrin In the coagulation cascade, the prothrombinase complex is the convergent point of the intrinsic (surface activated) and extrinsic (vessel injury-tissue factor) pathways (Biochemistry ( 1 991 ), Voi 30 p 10363, and Cell ( 1 988), Vol. 53, pp 505-51 8) The model of the coagulation cascade has been refined further with the discovery of the mode of action of tissue factor pathway inhibitor (TFPI) (Seminars in Hematology (1 992) , Vol. 29, pp 1 59-161 ) TFPI is a circulating multi-domain senne protease inhibitor with three Kunitz-hke serpin domains which competes with factor Va for free factor Xa Once formed, the binary complex of factor Xa and TFPI becomes a potent inhibitor of the factor Vila and tissue factor complex Factor Xa can be activated by two distinct complexes, by tissue factor Vila complex on the " Xa burst" pathway and by the factor IXa-VIIIA complex (TENase) of the "sustained Xa" pathway in the coagulation cascade. After vessel injury, the "Xa burst" pathway is activated via tissue factor (TF) Up regulation of the coagulation cascade occurs via increased factor Xa production via the " sustained Xa" pathway. Down regulation of the coagulation cascade occurs with the formation of the factor Xa-TFPI complex, which not only removes factor Xa but also inhibits further factor formation via the "Xa burst" pathway Therefore, the coagulation cascade is naturally regulated by factor Xa. The primary advantage of inhibiting factor Xa over thrombin in order to prevent coagulation is the focal role of factor Xa versus the multiple functions of thrombin Thrombin not only catalyzes the conversion of fibπnogen to fibrin, factor VIII to VINA, factor V to Va, and factor XI to Xla, but also activates platelets, is a monocyte chemotactic factor and mitogen for lymphocytes and smooth muscle cells Thrombin activates protein C, the in vivo anti coagulant mactivator of factors Va and Villa, when bound to thrombomodulin In circulation, thrombin is rapidly inactivated by antithrombin III (ATIII) and hepaπn cofactor II (HCII) in a reaction which is catalyzed by heparin or other proteoglycan-associated glycosaminoglycans, whereas thrombin in tissues is inactivated by the protease, nexin. Thrombin carries out its multiple cellular activation functions through a unique "tethered gand" thrombin receptor {Cell ( 1 991 ), Vol. 64, p . 1057), which requires the same anionic binding site and active site used in fibπnogen binding and cleavage and by thrombomodulin binding and protein C activation. Thus, a diverse group of in vivo molecular targets compete to bind thrombin and the subsequent proteolytic events will have very different physiological consequences depending upon which cell type and which receptor, modulator, substrate or inhibitor binds thrombin. Published data with the proteins antistasin and tick anti-coagulant peptide (TAP) demonstrate that factor Xa inhibitors are efficacious anti-coagulants ( Thrombosis and Haemostasis ( 1 992), Vol. 67, pp. 371 -376, and Science ( 1 990) , Vol 248, pp 593-596) The active site of factor Xa can be blocked by either a mechanism-based or a tight binding inhibitor (a tight binding inhibitor differs from a mechanism-based inhibitor by the lack of a covalent link between the enzyme and the inhibitor) Two types of mechanism-based inhibitors are known, reversible and irreversible, which are distinguished by ease of hydrolysis of the enzyme-inhibitor link ( Thrombosis Res ( 1 992), Vol 67, pp 221 231 , and Trends Pharmacol Sci ( 1 987), Vol 8, pp. 303-307) A series of guanidino compounds are examples of tight-binding inhibitors ( Thrombosis Res. ( 1980), Vol 19, pp 339-349) . Arylsulfonyl-arginine-pipeπdinecarboxylic acid derivatives have also been shown to be tight-binding inhibitors of thrombin (Biochem (1 984), Vol. 23, pp 85-90) , as well as a series of arylamidine-containing compounds, including 3-amιdιnophenylaryl derivatives ( Thrombosis Res ( 1 983), Vol 29, pp. 635-642) and bιs(amιdιno)benzyl cycloketones ( Thrombosis Res ( 1 980), Vol 1 7, pp 545-548) However, these compounds demonstrate poor selectivity for factor Xa Related Disclosures European Published Patent Application 0 540 051 (Nagahara et al ) describes aromatic amidine derivatives which are stated to be capable of showing a strong anticoagulant effect through reversible inhibition of factor Xa. The synthesis of σ,σ'-bιs(amιdιnobenzylιdene)cycloalkanones and σ,σ ' -bιs(amιdιno- benzyDcycloalkanones is described in Pharmazie ( 1977), Vol 32, No . 3, pp. 1 41 -145. These compounds are disclosed as being senne protease inhibitors. SUMMARY OF THE INVENTION This invention is directed to compounds or their pharmaceutically acceptable salts which inhibit human factor Xa and are therefore useful as pharmacological agents for the treatment of disease-states characterized by thrombotic activity. Accordingly, in one aspect, this invention provides compounds selected from the group consisting of the following formulae: α n wherein: A is -0-, -N(R 5 )-, or -S(0) n - (where n is 0, 1 or 2); Z 1 and Z 2 are independently -0-, -N(R 5 )- or -OCH 2 -; R 1 and R 4 are each independently hydrogen, halo, alkyl, -OR 8 , -C(0)OR 8 , -C(0)N(R 8 )R 9 , -N(R 8 )R 9 , -N(R 8 )C(0)R 9 , or -N(H)S(0) 2 R 1 1 ; R 2 is C(NH)NH 2 , -C(NH)N(H)OR 8 , -C(NH)N(H)C(0)OR 1 -C(NH)N(H)C(0)R 8 , -C(NH)N(H)S(0) 2 R 1 1 , or -C(NH)N(H)C{0)N(H)R 8 ; R 3 is halo, alkyl, haloalkyl, haloalkoxy, cyano, ureido, guanidino, -OR 8 , -C(NH)NH 2 , -C(NH)N(H)OR 8 , -C(0)N(R 8 )R 9 , -R 10 -C(0)N(R 8 )R 9 , -CH(OH)C(0)N(R 8 )R 9 , -N(R 8 )R 9 , -R 10 -N(R 8 )R 9 , -C(0)OR 8 , -R 10 -C(O)OR 8 , -N(R 8 )C(0)R 8 , (1 ,2)-tetrahydropyrιmιdιnyl (optionally substituted by alkyl), (1 ,2)-ιmιdazolyl (optionally substituted by alkyl), or ( 1 ,2)-ιmιdazolinyl (optionally substituted by alkyl); each R 5 is hydrogen, alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl); R 6 is hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, cycloalkyl, cycloalkylalkyl, -C(0)OR 8 , -R 1 0 -C(O)OR 8 , -R 1 0 -C(O)N(R 8 )R 9 , -C(O)-R 10 -N(R 8 )R 9 , -R 1 0 -C(O)R 8 , -R 1 0 -C(O)N(R 8 )N(R 8 )R 9 , -R 10 -C(R 8 ) (OR 9 )-R 1 0 -N(R 8 ) (R 9 ), -C(R 8 )(OR 8 )C(0)OR 9 , -R 1 0 -C(R 8 )(C(O)OR 9 ) 2 , -C(R 8 )(N(R 8 )R 9 )C(0)OR 8 , -R 1 0 -C(R 8 )(N(R 8 )R 9 )C(0)OR 8 , -C(R 8 )(OR 8 )R 9 , -R 1 0 -N(R 8 )R 9 , -R 1 0 -N(R 8 )C(0)OR 1 1 , -R 1 0 -N(R 8 )C(O)R 9 , -R 1 0 -N(R 8 )C(NR 8 )R 1 1 , -R 1 0 -N(R 8 )S(O) 2 R 1 \ -R 1 0 -N(R 8 )C(O)N(R 8 )R 9 , -R 10 -N(R 8 )C(NR 8 )N(R 8 )R 9 , -R 10 -N(R 8 )C(NR 8 )N(R 8 )N(R 8 )R 9 , -R 1 0 -N(R 8 )-R 0 -C(R 8 )(N(R 8 )R 9 )C(O)OR 8 , -R 1 0 -N(R 8 )S(0)R 9 , -R 1 0 OR 8 , -R 1 0 -ON(R 8 )C(NR 8 )N(R 8 )R 9 , -R 10 -OS(0) 2 OR 8 , -R 1 0 -P(O)(OR 8 )R 9 , -R 1 0 -OP(O)(OR 8 ) 2 , -R 1 0 -P(O)(OR 8 ) 2 , -R 1 0 -SR 8 , -R 10 -S-R 10 -C(O)OR 8 , -R 10 -S-R 10 -N(R 8 )R 9 , -R 1 0 -S-R 1 0 -C(R 8 )(N(R 8 )R 9 )C(O)OR 8 , -R 10 -S-R 1 0 -N(R 8 )C(O)0R 8 , -R 1 0 -S-R 1 0 -N(R 8 )C(O)R 8 , -R 1 0 -S-S-R 1 0 -C(R 8 )(N(R 8 )R 9 )C(O)OR 8 , -R 1 0 -SC(O)N(R 8 )R 9 , -R 1 0 -SC(S)N(R 8 )R 9 , -R 10 -S(0)R 8 , -R 10 -S(O) 2 R 1 1 , -R 10 -S(O)OR 8 , -R 10 -S(O) 2 OR 8 . -R 1 0 -S(O) 2 N(R 8 )R 9 , -R 1 0 -S(O)(NR 8 )R 9 ; or R 6 is aryl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -N(R 8 )R 9 , -C(0)OR 8 , -C(0) N(R 8 )R 9 , -S(0) 2 OR 8 and -OP(0)(OR 8 ) 2 ); or R 6 is aralkyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -N(R 8 )R 9 , -C(0)OR 8 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -OP(0)(OR 8 ) 2 ) ; or R 6 is heterocyclyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, aralkyl, -OR 8 , -CfOIOR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -OP(0)(OR 8 ) 2 ); or R 6 is heterocyclylalkyl (where the heterocyclyl radical is optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, aralkyl, -OR 8 , -SR 8 , -C(0)OR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 ), -S(0) 2 0R 8 and -0P(0)(0R 8 ) 2 ); or R 6 is adamantyl (optionally substituted by alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -C(0)OR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 , -S(0) 2 0R 8 and -0P(0)(0R 8 ) 2 ) ; or R 6 is adamantylalkyl (where the adamantyl radical is optionally substituted by alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -C(0)0R 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -0P(0)(0R 8 ) 2 ); R 7 is hydrogen, alkyl, cycloalkyl, aralkyl or aryl; each R 8 and R 9 is independently hydrogen, alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl) , or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, amino, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl , monoalkylaminocarbonyl, or dialkylaminocarbonyl), R 1 0 is a straight or branched alkylene chain; and R 1 1 is alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl , aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), as a single stereoisomer or a mixture thereof; or a pharmaceutically acceptable salt thereof. In another aspect, this invention provides compositions useful in treating a human having a disease-state characterized by thrombotic activity, which composition comprises a therapeutically effective amount of a compound of the invention as described above, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient. In another aspect, this invention provides a method of treating a human having a disease-state characterized by thrombotic activity, which method comprises administering to a human in need thereof a therapeutically effective amount of a compound of the invention as described above. In another aspect, this invention provides a method of treating a human having a disease-state alleviated by the inhibition of factor Xa, which method comprises administering to a human in need thereof a therapeutically effective amount of a compound of the invention as described above. In another aspect, this invention provides a method of inhibiting human factor Xa in vitro or in vivo by the administration of a compound of the invention. DETAILED DESCRIPTION OF THE INVENTION Definitions As used in the specification and appended claims, unless specified to the contrary, the following terms have the meaning indicated: "Alkyl" refers to a straight or branched chain monovalent or divalent radical consisting solely of carbon and hydrogen, containing no unsaturation and having from one to six carbon atoms, e.g. , methyl, ethyl, π-propyl, 1 -methylethyl (/so-propyl), π-butyl, 7-pentyl, 1 , 1 -dimethylethyl (r-butyl), and the like. "Alkenyl" refers to a straight or branched chain monovalent or divalent radical consisting solely of carbon and hydrogen, containing at least one double bond and having from one to six carbon atoms, e.g. , ethenyl, prop-1 -enyl, but-1 -enyl, pent-1 -enyl, penta-1 ,4-dιenyl, and the like "Alkynyl" refers to a straight or branched chain monovalent or divalent radical consisting solely of carbon and hydrogen, containing at least one triple bond and having from one to six carbon atoms, e.g , ethynyl, prop-1 -ynyl, but- 1 -ynyl, pent- 1 -ynyl, pent-3-ynyl, and the like "Alkoxy" refers to a radical of the formula -OR a where R a is alkyl as defined above, e g . methoxy, ethoxy, π-propoxy, 1 -methylethoxy (/so-propoxy), n-butoxy, ?-pentoxy, 1 , 1 -dιmethylethoxy (r-butoxy), and the like. "Alkoxycarbonyl" refers to a radical of the formula -C(0)OR a where R a is alkyl as defined above, e.g. , methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, /so-propoxycarbonyl, r-butoxycarbonyl, and the like. "Alkylene" refers to straight or branched chain divalent radical consisting solely of carbonyl and hydrogen, containing no unsaturation and having from one to six carbon atoms, e g , methylene, ethylene, propylene, ?-butylene, and the like. " Amidmo" refers to the radical -C(NH)-NH 2 . "Aminocarbonyl" refers to the radical -C(0)NH 2 . "Aryl" refers to a phenyl or naphthyl radical. " Aralkyl " refers to a radical of the formula -R a R b where R a is alkyl as defined above and R b is aryl as defined above, e.g , benzyl. " Aralkoxy" refers to a radical of the formula -OR c where R c is aralkyl as defined above, e g , benzyloxy, and the like. " Cycloalkyl" refers to a stable 3- to 7-membered monocyclic cyclic radical which is saturated, and which consist solely of carbon and hydrogen atoms, e g , cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and the like. " Cycloalkylalkyl" refers to a alkyl radical, as defined above, substituted by a cycloalkyl radical , as defined above, e.g. , (cyclobutyl)methyl, 2-(cyclopentyl)ethyl, 3-(cyclohexyl)propyl, and the like. " Dialkylamino" refers to a radical of the formula -NR a R a where each R a is independently an alkyl radical as defined above, e.g. , dimethylammo, methylethylamino, diethylam o, dipropylamino, ethylpropylamino, and the like " Dialkylaminocarbonyl" refers to a radical of the formula -C(0)NR a R a where each R a is independently an alkyl radical as defined above, e.g. , dimethylaminocarbonyl, methylethylaminocarbonyl, diethylaminocarbonyl, dipropylaminocarbonyl, ethylpropylaminocarbonyl, and the like. "Halo" refers to brσmo, lodo, chloro or fluoro. "Haloalkyl" refers to an alkyl radical, as defined above, that is substituted by one or more halo radicals, as defined above, e.g. , trifluoromethyl, difluoromethyl, tπchloromethyl, 2-trιfluoroethyl, 3-bromo-2-fluoropropyl, 1 -bromomethyl-2-bromoethyl, and the like. "Haloalkenyl" refers to an alkenyl radical, as defined above, that is substituted by one or more halo radicals, as defined above, e.g. , 2-dιfluoroethenyl, 3-bromo-2-fluoroprop-1 -enyl, and the like. "Haloalkoxy" refers to a radical of the formula -OR f where R f is haloalkyl as defined above, e.g , tπfluoromethoxy, difluoromethoxy, tπchloromethoxy, 2-trιfluoroethoxy, 1 -fluoromethyl-2-fluoroethoxy, 3-bromo-2-fluoroρropoxy, 1 -bromomethyl-2-bromoethoxy, and "Heterocyclyl" refers to a stable 3- to 1 0-membered monocyclic or bicyclic radical which is either saturated or unsaturated, and which consists of carbon atoms and from one to three heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and wherein the nitrogen, carbon or sulfur atoms may be optionally oxidized, and the nitrogen atom may be optionally quaternized. The heterocyclyl radical may be attached to the main structure at any heteroatom or carbon atom which results in the creation of a stable structure. Examples of such heterocyclic radicals include, but are not limited to, pipeπdinyl, piperazinyl, 2-oxopιperazιnyl, 2-oxopιperιdιnyl, 2-oxopyrrolιdιnyl, 2-oxoazepιnyl, azepmyl, pyrrolyl, 4-pιperιdonyl, pyrrolidmyl, pyrazolyl, pyrazolidinyl, imidazolyl, imidazolinyl, imidazolidinyl, pyridinyl, pyrazinyl, pyrimidinyl, pyπdaziπyl, oxazolyl, oxazolidinyi, triazolyl indanyl, isoxazolyl isoxazo dinyl, morpholinyl, thiazolyl, thiazolidinyl, isothiazolyl, quinuclidinyl isothiazolidinyl indolyl, isoindolyl, iπdolinyl, isoindolmyl, octahydroindolyl, octahydroisoiπdolyl, qumolyl, isoqumolyl, decahydroisoquinolyl, benzimidazolyl, thiadiazolyl, benzopyranyl, benzothiazolyl, benzoxazolyl, furyl, tetrahydrofuryl, tetrahydropyranyl, thienyl, benzothienyl, thiamorpholinyl, thiamorpholmyl sulfoxide, thiamorpholinyl sulfone, and oxadiazolyl. Preferred heterocyclyl radicals in this invention are indolyl, imidazolyl, thiazolyl, isoxazolyl, triazolyl, pyridinyl, thienyl. benzothienyl, furyl, and 3,4-dιhydro-2,3-dιoxo-1 (2H)-pyrιmιdιnyl. " Heterocyclylalkyl " refers to a radical of the formula -R a R g where R a is an alkyl radical as defined above and R g is a heterocyclyl radical as defined above, e.g. , mdolinylmethyl or imidazolylmethyl, and the like. " ( 1 ,2)-lmιdazolyl" refers to an imidazolyl radical attached at either the 1 - or 2-posιtιon " ( 1 ,2)-lmιdazolιnyl" refers to a 4,5-dιhydroιmιdazolyl radical attached at either the 1 - or the 2-posιtιon "Monoalkylamino" refers to a radical of the formula -NHR a where R a is an alkyl radical as defined above, e.g. , methylamino, ethylamino, propylamino, and the like. "Monoalkylaminocarbonyl" refers to a radical of the formula -C(0)NHR a where R a is an alkyl radical as defined above, e.g. , methylaminocarbonyl, ethylaminocarbonyl, propylaminocarboπyl, and the like. " (1 ,2)-Tetrahydropyrιmιdιnyl" refers to a tetrahydropyπmidinyl attached at either the 1 or 2-posιtιon "Adamantylalkyl" refers to a radical of the formula -R a R n where R a is an alkyl radical as defined above, and R h is an adamantyl radical, e.g. , adamantylmethyl, 2-adamantylethyl, and the like. "Optional" or "optionally" means that the subsequently described event of circumstances may or may not occur, and that the description includes instances where said event or circumstance occurs and instances in which it does not For example, "optionally substituted aryl" means that the aryl radical may or may not be substituted and that the description includes both substituted aryl radicals and aryl radicals having no substitution " Pharmaceutically acceptable salt" includes both acid and base addition salts. "Pharmaceutically acceptable acid addition salt" refers to those salts which retain the biological effectiveness and properties of the free bases, which are not biologically or otherwise undesirable, and which are formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuπc acid, nitric acid, phosphoric acid and the like, and organic acids such as acetic acid, tπfluoroacetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid maleic acid, malonic acid, succinic acid, fumaπc acid, tartaπc acid, citric acid , benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, and the like. "Pharmaceutically acceptable base addition salt" refers to those salts which retain the biological effectiveness and properties of the free acids, which are not biologically or otherwise undesirable. These salts are prepared from addition of an inorganic base or an organic base to the free acid. Salts derived from inorganic bases include, but are not limited to, the sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts and the like. Preferred inorganic salts are the ammonium, sodium, potassium, calcium, and magnesium salts. Salts derived from organic bases include, but are not limited to, salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as isopropylamine, tπmethylamine, diethylamine, tπethylamine, tπpropylamine, ethanolamme, 2-dιmethylamιnoethanol, 2-dιethylamιnoethanol, tπmethamine, dicyclohexylamine, lysine, arginine, histidme, caffeine, procaine, hydrabamme, choline, betaine, ethylenediamine, glucosamine, methylglucamine, theobromine, puπnes, piperazine, pipeπdine, Λ -ethylpιperιdιne, polyamine resins and the like. Particularly preferred organic bases are isopropylamine, diethylamine, ethanolamme, tπmethamine, dicyclohexylamine, choline and caffeine. "Therapeutically effective amount" refers to that amount of a compound of the invention which, when administered to a human in need thereof, is sufficient to effect treatment, as defined below , for disease-states characterized by thrombotic activity The amount of a compound of the invention which constitutes a "therapeutically effective amount" will vary depending on the compound, the disease-state and its severity, and the age of the human to be treated, but can be determined routinely by one of ordinary skill in the art having regard to his own knowledge and to this disclosure. "Treating" or "treatment" as used herein cover the treatment of a disease-state in a human, which disease-state is characterized by thrombotic activity; and include. (i) preventing the disease-state from occurring in a human, in particular, when such human is predisposed to the disease-state but has not yet been diagnosed as having it, (II) inhibiting the disease-state, i.e., arresting its development; or (in) relieving the disease-state, i .e., causing regression of the disease-state. The yield of each of the reactions described herein is expressed as a percentage of the theoretical yield . The compounds of the invention, or their pharmaceutically acceptable salts, may have asymmetric carbon atoms in their structure. The compounds of the invention and their pharmaceutically acceptable salts may therefore exist as single stereoisomers, racemates, and as mixtures of enantiomers and diastereomers. All such single stereoisomers, racemates and mixtures thereof are intended to be within the scope of this invention. It is noted that when R 1 is the same substituent as R 4 , R 2 is the same substituent as R 3 and Z 1 and Z 2 are the same, compounds of formula (I) are the same as compounds of formula (II) . For compounds of the invention, it is preferred that R 1 is at the 2-posιtιon of the phenyl group; that R 2 is at the 3-, 4-, or 5-posιtιon of the phenyl group; that R 3 is at the 3-, 4- or 5- position of the phenyl group; and that R 4 is at the 2-posιtιon of the phenyl group. The nomenclature used herein is a modified form of the I.U.P.A.C. system wherein the compounds of the invention are named, depending on what "A" is, as derivatives of 6(5 y)-pterdinones, 5/y-pyrιmιdo[4, 5-ώ][ 1 ,4]oxazιn-6(7r-7)-ones, or 5f/-pyrιmιdo[4, 5-ό][ 1 ,4]thιazιn- 6{7H)-ones. For example, a compound of formula (I) wherein A is -N(H)-; Z 1 and Z 2 are both -0-; R 1 is hydrogen; R 2 is -C(NH)NH 2 ; R 3 is -C(0)N(CH 3 ) 2 , R 4 is hydrogen; R 5 is hydrogen; R 6 is benzyl; and R 7 is hydrogen; e.g. : is named herein as 2-(2-hydroxy-5-amιdιnophenoxy)-4-(3-dιmethylamιnocarbonylphenoxy)- 7-benzyl-1 ,7-dιhydro-6(5W)-pteπdιnone. Utility and Administration A. Utility The compounds of the invention are inhibitors of factor Xa and therefore useful in disease-states characterized by thrombotic activity based on factor Xa's role in the coagulation cascade (see Background of the Invention above) . A primary indication for the compounds is prophylaxis for long term risk following myocardial infarction Additional indications are prophylaxis of deep vein thrombosis (DVT) following orthopedic surgery or prophylaxis of selected patients following a transient ischemic attack. The compounds of the invention may also be useful for indications in which coumadin is currently used, such as for DVT or other types of surgical intervention such as coronary artery bypass graft and percutaneous translumtnal coronary angioplasty. The compounds are also useful for the treatment of thrombotic complications associated with acute promyelocytic leukemia, diabetes, multiple myelomas , disseminated intravascular coagulation associated with septic shock, purpura fulminanas associated infection, adult respiratory distress syndrome, unstable angina, and thrombotic complications associated with aortic valve or vascular prosthesis The compounds are also useful for prophylaxis for thrombotic diseases, in particular in patients who have a high risk of developing such disease. In addition, the compounds of the invention are useful as in vitro diagnostic reagents for selectively inhibiting factor Xa without inhibiting other components of the coagulation cascade. B. Testing The primary bioassays used to demonstrate the inhibitory effect of the compounds of the invention on factor Xa are simple chromogenic assays involving only senne protease, the compound of the invention to be tested, substrate and buffer (see, e g. , Thrombosis Res ( 1 979), Vol 1 6, pp. 245-254) . For example, four tissue human senne proteases can be used in the primary bioassay, free factor Xa, prothrombinase, thrombin (lla) and tissue plasmmogen activator (tPA). The assay for TPA has been successfully used before to demonstrate undesired side effects in the inhibition of the fibπnolytic process (see, e.g , J Med Chem. ( 1 993), Vol. 36, pp 314-31 9) . Another bioassay useful in demonstrating the utility of the compounds of the invention in inhibiting factor Xa demonstrates the potency of the compounds against free factor Xa in citrated plasma. For example, the anticoagulant efficacy of the compounds of the invention will be tested using either the prothrombin time (PT) , or activated partial thromboplastin time (aPTT) while selectivity of the compounds is checked with the thrombin clotting time (TCT) assay. Correlation of the K, in the primary enzyme assay with the K, for free factor Xa in citrated plasma will screen against compounds which interact with or are inactivated by other plasma components . Correlation of the K, with the extension of the PT is a necessary in vitro demonstration that potency in the free factor Xa inhibition assay translates into potency in a clinical coagulation assay. In addition, extension of the PT in citrated plasma can be used to measure duration of action in subsequent pharmacodynamic studies. For further information on assays to demonstrate the activity of the compounds of the invention, see R. Lottenberg er a/ , Methods in Enzymology ( 1 981 ), Vol 80, pp, 341 -361 , and H Ohno et al . Thrombosis Research ( 1 980), Vol. 1 9, pp. 579-588. C. General Administration Administration of the compounds of the invention, or their pharmaceutically acceptable salts, in pure form or in an appropriate pharmaceutical composition, can be carried out via any of the accepted modes of administration or agents for serving similar utilities Thus, administration can be, for example, orally, nasally, parenterally, topically, transdermally, or rectally, in the form of solid, semi-solid, lyophilized powder, or liquid dosage forms, such as for example, tablets, suppositories, pills, soft elastic and hard gelatin capsules, powders, solutions, suspensions, or aerosols, or the like, preferably in unit dosage forms suitable for simple administration of precise dosages The compositions will include a conventional pharmaceutical carrier or excipient and a compound of the invention as the/an active agent, and, in addition, may include other medicinal agents, pharmaceutical agents, carriers, adjuvants, etc. Generally, depending on the intended mode of administration, the pharmaceutically acceptable compositions will contain about 1 % to about 99 % by weight of a compound(s) of the invention, or a pharmaceutically acceptable salt thereof, and 99% to 1 % by weight of a suitable pharmaceutical excipient Preferably, the composition will be about 5% to 75% by weight of a compound(s) of the invention, or a pharmaceutically acceptable salt thereof, with the rest being suitable pharmaceutical excipients. The preferred route of administration is oral, using a convenient daily dosage regimen which can be adjusted according to the degree of severity of the disease-state to be treated. For such oral administration, a pharmaceutically acceptable composition containing a compound(s) of the invention, or a pharmaceutically acceptable salt thereof, is formed by the incorporation of any of the normally employed excipients, such as, for example, pharmaceutical grades of mannitol, lactose, starch, pregelatinized starch, magnesium stearate, sodium saccharine, talcum, cellulose ether derivatives, glucose, gelatin, sucrose, citrate, propyl gallate, and the like. Such compositions take the form of solutions, suspensions, tablets, pills, capsules powders, sustained release formulations and the like. Preferably such compositions will take the form of capsule, caplet or tablet and therefore will also contain a diluent such as lactose, sucrose, dicalcium phosphate, and the like; a dismtegrant such as croscarmellose sodium or derivatives thereof, a lubricant such as magnesium stearate and the like; and a binder such as a starch, gum acacia, polyvinylpyrrolidone, gelatin, cellulose ether derivatives, and the like The compounds of the invention, or their pharmaceutically acceptable salts, may also be formulated into a suppository using, for example, about 0.5 % to about 50% active ingredient disposed in a carrier that slowly dissolves within the body, e g. , polyoxyethylene glycols and polyethylene glycols (PEG), e.g. , PEG 1 000 (96%) and PEG 4000 (4%) . Liquid pharmaceutically administrable compositions can, for example, be prepared by dissolving, dispersing, etc. , a compound(s) of the invention (about 0.5 % to about 20%), or a pharmaceutically acceptable sait thereof, and optional pharmaceutical adjuvants in a carrier, such as, for example, water, saline, aqueous dextrose, glycerol, ethanol and the like, to thereby form a solution or suspension. If desired, a pharmaceutical composition of the invention may also contain minor amounts of auxiliary substances such as wetting or emulsifying agents, pH buffering agents, antioxidants, and the like, such as, for example, citric acid, sorbitan monolaurate, tπethanolamine oleate, butylated hydroxytoluene, etc. Actual methods of preparing such dosage forms are known, or will be apparent, to those skilled in this art; for example, see Remington 's Pharmaceutical Sciences, 1 8th Ed. , (Mack Publishing Company, Easton, Pennsylvania, 1 990). The composition to be administered will, in any event, contain a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof, for treatment of a disease-state alleviated by the inhibition of factor Xa in accordance with the teachings of this invention. The compounds of the invention, or their pharmaceutically acceptable salts, are administered in a therapeutically effective amount which will vary depending upon a variety of factors including the activity of the specific compound employed, the metabolic stability and length of action of the compound, the age, body weight, general health, sex, diet, mode and time of administration, rate of excretion, drug combination, the severity of the particular disease-states, and the host undergoing therapy. Generally, a therapeutically effective daily dose is from about 0.14 mg to about 14.3 mg/kg of body weight per day of a compound of the invention, or a pharmaceutically acceptable salt thereof; preferably, from about 0.7 mg to about 10 mg/kg of body weight per day; and most preferably, from about 1 .4 mg to about 7.2 mg/kg of body weight per day. For example, for administration to a 70 kg person, the dosage range would be from about 10 mg to about 1 .0 gram per day of a compound of the invention, or a pharmaceutically acceptable salt thereof, preferably from about 50 mg to about 700 mg per day, and most preferably from about 1 00 mg to about 500 mg per day. Preferred Embodiments Of the compounds of the invention as set forth above in the Summary of the Invention, a preferred group are those compounds wherein A is -0- or -N(R 5 )-; Z 1 and Z 2 are both -0-; R 1 and R 4 are each independently hydrogen, halo or -OR 8 ; R 2 is -C(NH)NH 2 , -C(NH)N(H)S(0) 2 R 1 1 or -C(NH)N(H)C(0)N(H)R 8 ; R 3 is ureido, guanidmo, -OR 8 , -C(0)N(R 8 )R 9 , -N(R 8 )R 9 , -C(0)OR 8 , -N(R 8 )C(0)R 8 , ( 1 ,2)-tetrahydropyrιmιdιnyl (optionally substituted by alkyl), ( 1 ,2)-ιmιdazolyl (optionally substituted by alkyl), or (1 ,2)-ιmιdazolιnyl (optionally substituted by alkyl); each R 5 is hydrogen, alkyl, aryl (optionally substituted by halo), or aralkyl (optionally substituted halo); R 6 is hydrogen, alkyl, -R 10 -C(O)OR 8 , -R 1 0 -C(O)N(R 8 )R 9 , -R 1 0 -C(R 8 )(C(O)OR 9 ) 2 , -R 10 -N(R 8 )R 9 , -R 1 0 -N(R 8 )C(NR 8 )R n , -R 1 0 -N(R 8 )C(O)N(R 8 )R 9 , -R 1 0 -N(R 8 )C(NR 8 )N(R 8 )R 9 , -R 10 OR 8 , -R 1 0 -OP(O)(OR 8 ) 2 , -R 1 0 -SR 8 , or -R 1 0 -S(O) 2 R 1 1 ; or R 6 is aryl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy and - OR 8 ); or R 6 is aralkyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy and -OR 8 ); or R 6 is heterocyclyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy and -OR 8 ); or R 6 is heterocyclylalkyl (where the heterocyclyl radical is optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy or -OR 8 ); R 7 is hydrogen, alkyl, cycloalkyl, aralkyl or aryl; each R 8 and R 9 is independently hydrogen, alkyl, aryl (optionally substituted by halo, alkyl, hydroxy or alkoxy) , or aralkyl (optionally substituted by halo, alkyl, hydroxy or alkoxy); R 10 is a straight or branched alkylene chain, and R 1 1 is alkyl, aryl (optionally substituted by halo, alkyl, hydroxy or alkoxy), or aralkyl (optionally substituted by halo, alkyl, hydroxy or alkoxy). Of this group of compounds, a preferred subgroup of compounds is that subgroup wherein A is -N(R 5 )-, Z 1 and Z 2 are both -0-; R ' and R 4 are each independently hydrogen or -OR 8 ; R 2 is -C(NH)NH 2 , R 3 is -C(0)N(R 8 )R 9 , ( 1 ,2)-tetrahydropyrιmιdιnyl (optionally substituted by alkyl) , ( 1 ,2)-ιmιdazolyl (optionally substituted by alkyl), or ( 1 ,2)-ιmιdazolιnyl (optionally substituted by alkyl), each R 5 is hydrogen, alkyl, aryl (optionally substituted by halo), or aralkyl (optionally substituted halo); R 6 is hydrogen, alkyl, -R 1 0 -C(0)OR 8 , -R 10 -C(0)N(R 8 )R 9 , -R 10 -C(R 8 )(C(0)OR 9 ) 2 , -R 1 0 -N(R 8 )R 9 , -R 1 0 -N(R 8 )C(NR 8 )R 1 1 , -R 10 -N(R 8 )C(0)N(R 8 )R 9 , -R 10 -N(R 8 )C(NR 8 )N(R 8 )R 9 , -R 10 OR 8 , -R 10 -OP(O)(OR 8 ) 2 , -R 1 0 -SR 8 , or -R 10 -S(O) 2 R 1 ■ ; or R 6 is aralkyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy and -OR 8 ); or R 6 is imidazolylalkyl or mdolylalkyl; R 7 is hydrogen or alkyl; each R 8 and R 9 is independently hydrogen, alkyl, aryl, or aralkyl; R 10 is a straight or branched alkylene chain; and R 1 1 is alkyl or aryl. Of this subgroup of compounds, a preferred class of compounds is that class wherein R 1 is -OR 8 ; R 2 is -C(NH)NH 2 ; R 3 is -C(0)N(R 8 )R 9 , (1 ,2)-ιmιdazolyl (optionally substituted by methyl) , or (1 ,2)-ιmιdazolιnyl (optionally substituted by methyl); each R 5 is hydrogen, alkyl, aryl or aralkyl; R 6 is hydrogen, alkyl, -R 1 0 -C(O)OR 8 , -R 10 -C(O)N(R 8 )R 9 , -R 1 0 -C(R 8 )(C(0)OR 9 ) 2 , - R 1 0 -N(R 8 )R 9 , -R 1 0 -N(R 8 )C(NR 8 )R 1 1 , -R 0 -N(R 8 )C(0)N(R 8 )R 9 , -R 10 -N(R 8 )C(NR 8 )N(R 8 )R 9 , -R 1 0 OR 8 , -R 10 -OP(O)(OR 8 ) 2 , -R 1 0 -SR 8 , or -R 10 -S(0) 2 R 1 1 ; or R 6 is aralkyl (optionally substituted by one or more substituents selected from the group consisting of methyl and hydroxy); or R 6 is imidazolylalkyl or indolylalkyl; R 7 is hydrogen or alkyl; each R 8 and R 9 is independently hydrogen, alkyl, aryl, or aralkyl; R 1 0 is a straight or branched alkylene chain, and R 1 1 is alkyl or aryl . Of this class of compounds, a preferred subclass of compounds is that subclass wherein A is -N(H)-; Z 1 and Z 2 are both -0-; R 1 is hydroxy; R 2 is -C(NH)NH 2 , R 3 is -C(0)N(CH 3 ) 2 ; and R 4 , R 5 , R 6 , and R 7 are hydrogen. A preferred compound of this subclass of compounds is that compound selected from formula (I), namely, 2-(2-hydroxy-5-amιdιnophenoxy)-4-(3-(dιmethylamιnocarbonyl)phenoxy)- 1 , 7- dihydro-6(5/ )-pterιdιπone. Another preferred compound of this subclass of compounds is that compound selected from formula (II), namely, 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-hydroxy-5-cyanophenoxy)- 1 ,7-dιhydro-6(5/Y)-pterιdιnone. Another preferred subgroup of compounds is that subgroup wherein A is -0-, Z 1 and Z 2 are both -0-, R 1 and R 4 are each independently hydrogen or -OR 8 ; R 2 is -C(NH)NH 2 ; R 3 is -C(0)N(R 8 )R 9 , (1 ,2)-tetrahydropyrιmιdιnyl (optionally substituted by alkyl), ( 1 ,2)-ιmιdazolyl (optionally substituted by alkyl), or ( 1 ,2)-ιmιdazolιnyl (optionally substituted by alkyl); R 5 is hydrogen, alkyl, aryl (optionally substituted by halo), or aralkyl (optionally substituted halo); R 6 is hydrogen, alkyl, -R 1 0 -C(0)OR 8 , -R 10 -C(O)N(R 8 )R 9 , -R 1 0 -C(R 8 )(C(0)OR 9 ) 2 , -R 1 0 -N(R 8 )R 9 , -R 10 -N(R 8 )C(NR 8 )R 1 1 , -R 10 -N(R 8 )C(0)N(R 8 )R 9 , -R 1 0 -N(R 8 )C(NR 8 )N(R 8 )R 9 , -R 10 OR 8 , -R 1 0 -OP(O)(OR 8 ) 2 , -R 1 0 -SR 8 , or -R 1 0 -S(0) 2 R 1 1 ; or R 6 is aralkyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy and -OR 8 ); or R 6 is imidazolylalkyl or indolylalkyl; R 7 is hydrogen or alkyl; each R 8 and R 9 is independently hydrogen, alkyl, aryl, or aralkyl; R 10 is a straight or branched alkylene chain; and R 1 1 is alkyl or aryl. Of this subgroup of compounds, a preferred class of compounds is that class wherein R 1 is -OR 8 ; R 2 is -C(NH)NH 2 ; R 3 is -C(0)N(R 8 )R 9 , ( 1 ,2)-ιmιdazolyl (optionally substituted by methyl), or (1 ,2)-ιmtdazolιnyl (optionally substituted by methyl); R 5 is hydrogen, alkyl, aryl or aralkyl; R 6 is hydrogen, alkyl, -R 10 -C(O)OR 8 , -R 1 0 -C(O)N(R 8 )R 9 , -R 1 0 -C(R 8 ) (C(O)OR 9 ) 2 , -R 10 -N(R 8 )R 9 , -R 1 0 -N(R 8 )C(NR 8 )R 1 1 , -R 1 0 -N(R 8 )C(O)N(R 8 )R 9 , -R 1 -R 1 0 OR 8 , -R 10 -OP(O)(OR 8 ) 2 , -R 1 0 -SR 8 , or -R 1 0 -S(O) 2 R - ■ ; or R 6 is aralkyl (optionally substituted by one or more substituents selected from the group consisting of methyl and hydroxy) , or R 6 is imidazolylalkyl or indolylalkyl; R 7 is hydrogen or alkyl; each R 8 and R 9 is independently hydrogen, alkyl , aryl, or aralkyl; R 1 0 is a straight or branched alkylene chain; and R 1 ' is alkyl or aryl. Of this class of compounds, a preferred subclass of compounds is that subclass wherein A is -0-, Z 1 and Z 2 are both -0-, R 1 is hydroxy; R 2 is -C(NH)NH 2 , R 3 is -C(0)N(CH 3 ) 2 , and R 4 , R 5 , R 6 , and R 7 are hydrogen. A preferred compound of this subclass of compounds is that compound selected from formula (I), namely, 2-(2-hydroxy-5-amιdιnophenoxy)-4-(3-(dιmethylamιnocarbonyl)phenoxy)-5 - pyπmιdo ' 4, 5-o][ 1 ,4]oxazιn-6(7/ )-one. Preparation of Compounds of The Invention It is understood that in the following description, combinations of substituents and/or variables (e.g. , R 6 and R 7 ) in the depicted compounds are permissible only if such combinations result in stable compounds . A. Preparation of Compounds of Formula (la) Compounds of formula (la) are compounds of formula (I) where A is -N(H)-, Z 1 and Z 2 are both -0- and R 2 is -C(NH)NH 2 . These compounds may be prepared as illustrated in the following Reaction Scheme 1 wherein R 1 and R 4 are each independently hydrogen, halo, alkyl, -OR 8 , -C(0)0R 8 , -C(0)N(R 8 )R 9 , -N(R 8 )R 9 , -N(R 8 )C(0)R 9 , or -N(H)S(0) 2 R 1 • ; R 3 is halo, alkyl, haloalkyl, haloalkoxy, cyano, ureido, guanidmo, -OR 8 , -C(NH)NH 2 , -C(NH)N(H)OR 8 , -C(0)N(R 8 )R 9 , -R 1 0 -C(0)N(R 8 )R 9 , -CH(0H)C(0)N(R 8 )R 9 , -N(R 8 )R 9 , -R 1 0 -N(R 8 )R 9 , -C(0)OR 8 , -R 1 0 -C(O)OR 8 , -N(R 8 )C(0)R 8 , ( 1 ,2)-tetrahydropyrιmιdιnyl (optionally substituted by alkyl), (1 ,2)-ιmιdazolyl (optionally substituted by alkyl), or (1 ,2)-ιmιdazolιnyl (optionally substituted by alkyl); R 5 is hydrogen, alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl , aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl) , R 6 is hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, cycloalkyl, cycloalkylalkyl, -C(0)OR 8 , -R 1 0 -C(0)OR 8 , -R 1 0 -C(O)N(R 8 )R 9 , -C(0)-R 1 0 -N(R 8 )R 9 , -R 10 -C(O)R 8 , -R 1 0 -C(O)ιM(R 8 )N(R 8 )R 9 , -R 1 0 -C(R 8 )(OR 9 )-R 1 0 -N(R 8 )(R 9 ), -C(R 8 )(OR 8 )C(0)OR 9 , -R 1 0 -C(R 8 )(C(O)OR 9 ) 2 , -C(R 8 )(N(R 8 )R 9 )C(0)OR 8 , -R 10 -C(R 8 )(N(R 8 )R )C(O)OR 8 , -C(R 8 )(OR 8 )R 9 , -R 10 -N(R 8 )R 9 , -R 1 0 -N(R 8 )C(O)OR 1 1 , -R 10 -N(R 8 )C(O)R 9 , -R 10 -N(R 8 )C(NR 8 )R 1 -R 1 0 -N(R 8 )S(O) 2 R 1 1 , -R 1 0 -N(R 8 )C(O)N(R 8 )R 9 , -R 10 -N(R 8 )C(NR 8 )N(R 8 )R 9 , -R 1 0 -N(R 8 )C(NR 8 )N(R 8 )N(R 8 )R 9 , -R 1 0 -N(R 8 )-R 1 0 -C(R 8 )(N(R 8 )R 9 )C(O)OR 8 , -R 1 0 -N(R 8 )S(O)R 9 , -R 0 OR 8 , -R 1 0 -ON(R 8 )C(NR 8 )N(R 8 )R 9 , -R 10 -OS(O) 2 OR 8 , -R 10 -P(O)(OR 8 )R 9 , -R 10 -OP(O)(OR 8 ) 2 , -R 10 -P(O) (OR 8 ) 2 , -R 10 -SR 8 , -R 10 -S-R 10 -C(O)OR 8 , -R 10 -S-R 10 -N(R 8 )R 9 , -R 10 -S-R 10 -C(R 8 )(N(R 8 )R 9 )C(O)OR 8 , -R l 0 -S-R 10 -N(R 8 )C(O)OR 8 , -R 10 -S-R 1 0 -N(R 8 )C(O)R 8 , -R 1 0 -S-S-R 1 0 -C(R 8 )(N(R 8 )R 9 )C(O)OR 8 , -R 0 -SC(O)N(R 8 )R 9 , -R 1 0 -SC(S)N(R 8 )R 9 , -R 10 -S(O)R 8 , -R 10 -S(O) 2 R 1 \ -R 1 0 -S(O)OR 8 , -R 1 0 -S(O) 2 OR 8 , -R 1 0 -S(O) 2 N(R 8 )R 9 , -R 1 0 -S(O)(NR 8 )R 9 ; or R 6 is aryl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -N(R 8 )R 9 , -C(0)OR 8 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -OP(0)(OR 8 ) 2 ); or R 6 is aralkyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -N(R 8 )R 9 , -C(0)OR 8 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -OP(0)(OR 8 ) 2 ); or R 6 is heterocyclyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, aralkyl, -OR 8 , -C(0)OR 8 , -ι\l(R 8 )R 9 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -OP(0)(OR 8 ) 2 ); or R 6 is heterocyclylalkyl (where the heterocyclyl radical is optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, aralkyl, -OR 8 , -SR 8 , -C(0)OR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 ) , -S(0) 2 OR 8 and -OP(0)(OR 8 ) 2 ); or R 6 is adamantyl (optionally substituted by alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -C(0)OR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -0P(0)(0R 8 ) 2 ), or R 6 is adamantylalkyl (where the adamantyl radical is optionally substituted by alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -C(0)OR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -OP(0) (OR 8 ) 2 ); R 7 is hydrogen, alkyl, cycloalkyl, or aryl; each R 8 and R 9 is independently hydrogen, alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, am o, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl , monoalkylaminocarbonyl, or dialkylaminocarbonyl), or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, a mo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl); R 1 0 is a straight or branched alkylene chain; R 1 1 is alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, am o, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl) , or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, am o, dialkylamino , monoalkylamino, 1 carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl) , R is hydrogen, alkyl, aryl or aralkyl; and X is halo: REACTION SCHEME 1 I Λ ) ( B ) ; c REACTION SCHEME 1 continued Compounds of formulae (A), (B) , (D), and (G) are commercially available, for example, from Aldπch Chemical Co. , or Sigma Chemical Co. , or ICN Biomedicals, or may be prepared according to methods known to those skilled in the art. In general, compounds of formula (la) were prepared by first treating a compound of formula (A) in an aprotic solvent, for example, acetonitrile, at temperatures from about - 10°C to about 10° C, preferably at about 0°C, in the presence of a base, preferably cesium carbonate, with an equimolar amount of a compound of formula (B). The resulting reaction mixture was stirred at ambient temperature for about 1 2 to about 16 hours, preferably for about 1 6 hours. A compound of formula (C) was then isolated from the reaction mixture by standard isolation techniques, such as in vacua removal of solvent and chromatography. The compound of formula (C) in an aprotic solvent, preferably acetonitrile, at temperatures from about -10°C to about 10°C, preferably at about 0°C, was treated with an equimoiar amount of a compound of formula (D) in the presence of a base, preferably cesium carbonate The resulting mixture was allowed to warm to ambient temperature and stirred for about 1 hour to about 4 hours, preferably for about 2 hours A compound of formula (E) was then isolated from the reaction mixture by standard isolation techniques, such as evaporation of the solvents. The compound of formula (E) in a protic solvent, preferably a lower alkanol such as methanol, at temperatures from about -10°C to about 10°C, preferably at about 0 °C, was then treated with a strong oxidizing agent, such as potassium metabisulfite (KHS0 5 ) in water. The resulting reaction mixture was stirred for about 1 2 hours to about 1 6 hours, preferably for about 1 5 hours, at ambient temperature. The reaction mixture is then concentrated and extracted with an aprotic organic solvent, such as methylene chloride. A compound of formula (F) was isolated from the organic layer by standard isolation techniques, such as evaporation of the solvents. The compound of formula (F) in an aprotic solvent, preferably acetonitrile, at temperatures from about - 10°C to about 10°C, preferably at about 0°C, was treated with an equimolar amount of a compound of formula (G) in the presence of a base, preferably cesium carbonate. The resulting reaction mixture was stirred for 15 minutes to about 1 hour, preferably for about 1 5 minutes. A compound of formula (H) was isolated from the reaction mixture by standard isolation techniques, such as evaporation of the solvents and chromatography. The compound of formula (H) in a mixture of a water miscible ethereal solvent, such as tetrahydrofuran, and an aqueous weak mineral acid, such as 10% hydrochloric acid, was treated with a reducing agent, such as granular zinc or hydrogen/palladium on carbon. The reaction mixture was heated for about 10 minutes to about 1 hour, preferably for about 30 minutes, at about 50 °C to about 100 °C, preferably at about 70°C. The volatiles were evaporated and the resulting acidic solution was neutralized by a weak base, such as sodium bicarbonate The compound of formula (J) was then isolated from the reaction mixture by standard isolation techniques, such as extraction with an organic solvent and evaporation of the solvent. The compound of formula (J) was then dissolved in a lower alkanol , preferably ethanol, at temperatures from about -10°C to about 10°C, preferably at about 0° C, and the resulting solution was then saturated with a mineral acid gas, preferaby hydrochloric acid. The reaction mixture was sealed and allowed to warm to ambient temperature over a period of time from about 1 2 hours to about 1 6 hours, preferably for about 1 6 hours. The reaction mixture was concentrated and a polar solvent, such as ether, was added to the concentrated mixture The resulting precipitate was then dissolved in a lower alkanol, preferably ethanol, and the resulting solution was cooled to about -10°C to about 10°C, preferably to about 0°C, and then treated with anhydrous ammonia (gas) for about 5 minutes to about 20 minutes, preferably for about 10 minutes. The reaction mixture was sealed and heated to temperatures from about ambient temperature to about 100°C, preferably to about 60°C, for about 1 hour to about 2 hours, preferably for about 2 hours. The reaction mixture was cooled and the solvents were evaporated. A compound of formula (la) was isolated from the reaction mixture by standard isolation techniques, such as filtration, evaporation of the solvents, and purification by preparative HPLC. The compounds of formula (la) so formed may further be treated by the method described in Marfat, A. , et a/. , Synthesis (1987), Vol. 5, p. 515, with a compound of formula XR 5 where X is bromo or chloro and R 5 is alkyl or optionally substituted aralkyl as described above in the Summary of the Invention to prepare compounds of formula (la) wherein the nitrogen atom at the 5-posιtιon is substituted by alkyl or optionally substituted aralkyl. Alternatively, the compounds of formula (la) may further be treated with an OΛfΛo-nitro- haloaromatic, preferably with an OΛfΛo-nitro-fluoroaromatic, such as O rΛo-mtrofluorobenzene, in the presence of a strong base, such as sodium hydride, to produce compounds of formula (la) wherein the nitrogen at the 5-posιtιon is substituted by a nitro-aryl group, such as 2-nιtrophenyl Reductive de-amination of the nitro-aryl group can then be carried out by first reducing the nitro group to the corresponding am o group by treating the compound with SnCI 2 as described in Bellamy, F.D. , et a/. , Tetrahedron Letters ( 1 984), Vol. 26, p. 839 The resulting ammo compound can then be de-ammated by treating the compound with a standard deaminating agent, such as f-butylnitπte, in an aprotic solvent, such as DMF, at temperatures from about 35 °C to about 90°C, preferably at about 65 °C (see Doyle, M .P , et al , J Org. Chem ( 1 974) , Vol. 42, p. 3494) . Alternatively, instead of treating the resulting solution above with anhydrous ammonia, the resulting solution may be treated with a compound of the formula NH 2 OR 8 to afford the compound of formula (I) wherein R 2 is -C(NH)N(H)OR 8 Compounds of formula (la) wherein R 3 is -C(NH)NH 2 or -C(NH )N(H)OR 8 are produced from the corresponding cyano compounds in a similar manner as that described above for compounds of formula (J) . In addition, compounds of formula (la) wherein R 1 , R 3 , R 4 , R 5 or R 6 contains a -C(0)N(R 8 )R 9 group or a -C(0)OR 8 group (where each R 8 and R 9 is independently alkyl, optionally substituted aryl or optionally substituted aralkyl) may be hydrolyzed under acidic conditions to prepare compounds of the invention where R 1 , R 3 , R 4 , R 5 or R 6 contains a carboxy group. In addition, compounds of formula (la) where R 1 , R 3 , R 4 , R 5 or R 6 contains an ammo group can be treated with the appropriate alkylating agents to afford the corresponding compounds of formula (la) where R 1 , R 3 , R 4 , R 5 or R 6 contains -N(R 8 )R 9 or -N(R 8 )C(0)R 9 where each R 8 and R 9 is independently hydrogen, alkyl, optionally substituted aryl or optionally substituted aralkyl. In addition, compounds of formula (la) wherein R 1 , R 3 , R 4 , R 5 or R 6 contains a C(0)0R 8 group where R 8 is hydrogen, alkyl, optionally substituted aryl or optionally substituted aralkyl may be amidated under standard amidation conditions to form the corresponding compounds of formula (la) where R 1 , R 3 , R 4 , R 5 or R 6 contains a -C(0)N(R 8 )R 9 group where R 8 and R 9 are independently hydrogen, alkyl, optionally substituted aryl or optionally substituted aralkyl. Compounds of formula (la) may be further treated with the appropriate acid halide, preferably acid chloride, or with the appropriate acid anhydride or an equivalent, to yield compounds of the invention wherein R 2 is -C(NH)N(H)C(0)R 8 where R 8 is hydrogen, alkyl, optionally substituted aryl or optionally substituted aralkyl. Alternatively, compounds of formula (la) may further be treated with carbamoyl chlorides or their equivalents to yield compounds of the invention where R 2 is -C(NH)N(H)C(0)OR 1 ' where R 1 1 is described above in the Summary of the Invention. Alternatively, compounds of formula (la) may be further treated with compounds of the formula R 1 1 -S(0) 2 -ιmιdazole, where R 1 1 is as described in the Summary of the Invention, in a polar solvent, such as methylene chloride, at ambient temperature to afford compounds of the invention where R 2 is -C(NH)N(H)S(0) 2 R 1 1 . Alternatively, compounds of formula (la) may be further treated with an appropriately Λ/-R 8 -substιtuted phenylcarbamate in a polar solvent, preferably methylene chloride, at ambient temperature, for about 6 to 24 hours, preferably for about 1 2 hours, to afford compounds of the invention where R 2 is -C(NH)N(H)C(0)N(H)R 8 . B. Preparation of Compounds of Formula (lla) Compounds of formula (lla) are compounds of formula (II) wherein A is -N(H)-; Z 1 and Z 2 are both -0-, and R 2 is -C(NH)NH 2 . These compounds may be prepared as illustrated in the following Reaction Scheme 2 wherein R 1 , R 3 , R 4 , R 5 , R 6 , R 7 and R 1 2 are as defined above for Reaction Scheme 1 ; and X is halo: REACTION SCHEME 2 1 G ) R M ) v N ) REACTION SCHEME 2 continued Compounds of formulae (A), (B) , (D) and (G) are commercially available, for example, from Aldπch Chemical Co , or Sigma Chemical Co , or ICN Biomedicals or may be prepared according to methods known to those skilled in the art In general, compounds of formula (lla) were prepared by first treating a compound of formula (A) with a compound of formula (G) in a manner similar to that described above for the preparation of compounds of formula (H) from compounds of formula (F) and (G) The resulting compound of formula (K) was isolated from the reaction mixture and treated with a compound of formula (D) in a manner similar to that described above for the compound of formula (C) The resulting compound of formula (L) was isolated from the reaction mixture and then oxidized in a manner similar to that described above for the compounds of formula (E) The resulting compound of formula (M) was isolated from the reaction mixture and then treated with a compound of formula (B) in a manner similar to that described above for the compound of formula (A). The resulting compound of formula (N) was isolated from the reaction mixture, and then was reduced and cychzed in a manner similar to that described above for a compound of formula (H) The resulting compound of formula (0) was then treated in a manner similar to that described above for the compound of formula (J) The resulting compound of formula (lla) was isolated from the reaction mixture by standard techniques. In addition, all the various substituent conversions described above for the compounds of formula (la) apply to the compounds of formula (lla) to afford additional compounds of the invention not specifically depicted in the foregoing Reaction Scheme C. Preparation of Compounds of formula (lb) Compounds of formula (lb) are compounds of formula (I) wherein A is -0-; Z 1 and Z 2 are both -0-; and R 2 is -C(NH)NH 2 . These compounds may be prepared as illustrated below in Reaction Scheme 3 wherein R 1 , R 3 , R 4 , R 5 , R 6 , R 7 and R 1 2 are as described above for Reaction Scheme 1 ; and X is halo: REACTION SCHEME 3 ( C , REACTION SCHEME 3 continued Compounds of formula (C) are prepared as described above in Reaction Scheme 1 Compounds of formula (P) and formula (G) are commercially available, for example, from Aldrich Chemical Co or Sigma Chemical Co, or may be prepared according to methods known to those skilled in the art In general the compounds of formula (lb) were prepared by first generating the alkoxide ion of the compound of formula (P) by treating the compound with a strong base, preferably sodium hydride in a polar aprotic solvent, preferably tetrahydrofuran, from about 0° C to about ambient temperature, preferably at about 0° C The resulting solution, containing the alkoxide was added dropwise to a compound of formula (C) at about 0°C to about 1 0°C, preferably at about 0 °C the reaction mixture was stirred for about 30 minutes to about 2 hours, preferably for about 1 hour, from about 0°C to about 1 0 ° C, preferably at about 0 °C The reaction mixture was then warmed to ambient temperature and stirred for about 1 hour to about 3 hours preferably for about 2 hours. The compound of formula (Q) was then isolated from the reaction mixture by conventional isolation techniques, such as by evaporation of the volatiles The compound of formula (Q) was then oxidized to a compound of formula (R) in a manner similar to that described above for compounds of formula (E) in preparing compounds of formula (F) The compound of formula (R) so formed was then treated with a compound of formula (G) to produce a compound of formula (S) in a manner similar to that described above for compounds of formula (F) in preparing compounds of formula (H) The compound of formula (S) so formed was then cyclized to produce a compound of formula (T) in a manner similar to that described above for compounds of formula (H) in preparing compounds of formula (J) The compound of formula (T) so formed was then treated in a manner similar to that described above for compounds of formula (J) in preparing compounds of formula (la) to produce a compound of formula (lb) . In addition, all the various substituent conversions described above for the compounds of formula (laj apply to the compounds of formula (lb) so formed to afford additional compounds of the invention not specifically depicted in the foregoing Reaction Scheme D. Preparation of Compounds of Formula (lib) Compounds of formula (lib) are compounds of formula (II) wherein A is -0-; Z 1 and Z 2 are both -0-; and R 2 is -C(NH)NH . These compounds may be prepared as illustrated below in Reaction Scheme 3 wherein R 1 , R 3 , R 4 , R 5 , R 6 , R 7 and R 1 2 are as described above for Reaction Scheme 1 ; and X is halo: REACTION SCHEME 4 ( K ) 0 ( B ) ( ) REACTION SCHEME 4 continued Compounds of formula (K) are prepared as described above in Reaction Scheme 2 Compounds of formula (P) and formula (B) are commercially available, for example, from Aldrich Chemical Co or Sigma Chemical Co, or may be prepared according to methods known to those skilled in the art. In general, the compounds of formula (lib) are prepared by first generating the alkoxide ion of the compound of formula (?) as described above for compounds of formula (C) in Reaction Scheme and then treating a compound of formula (K) with the alkoxide so formed to produce a compound of formula (U) The compound of formula (U) is then oxidized to a compound of formula (V) in a manner similar to that described above for compounds of formula (L) in preparing compounds of formula (M) The compound of formula (V) so formed was then treated with a compound of formula (B) to produce a compound of formula (W) in a manner similar to that described above for compounds of formula (M) in preparing compounds of formula (N) The compound of formula (W) so formed was then cyclized to produce a compound of formula (X) in a manner similar to that described above for compounds of formula (N) in preparing compounds of formula (O) The compound of formula (X) so formed was then treated in a manner similar to that described above for compounds of formula (O) in preparing compounds of formula (lla) to produce a compound of formula (lib) In addition, all the various substituent conversions described above for the compounds of formula (la) apply to the compounds of formula (lib) so formed to afford additional compounds of the invention not specifically depicted in the foregoing Reaction Scheme. In addition, all compounds of the invention that exist in free base form or free acid form may be converted to their pharmaceutically acceptable salts by treatment with the appropriate inorganic or organic acid, or by the appropriate inorganic or organic base Salts of the compounds of the invention can also be converted to the free base form or to the free acid form or to another salt by methods known to those of ordinary skill in the chemical arts The following specific preparations and examples are provided as a guide to assist in the practice of the invention, and are not intended as a limitation on the scope of the invention PREPARATION 1 Compounds of formula (C), formula (N) and formula (W) A. To 2-methylthιo-4,6-dιchloro-5-nιtropyrιmιdιne, a compound of formula (A) , (5 0 g, 20.8 mmol) in 200 mL acetonitrile at 0°C was added cesium carbonate (8.82 g , 27.1 mmol) followed by the addition of 3-(dιmethylamιnocarbonyl)phenol (3.44 g, 20 8 mmol), a compound of formula (B), and the reaction mixture was stirred for 16 hours. The volatiles were evaporated and the residue chromatographed on silica gel (CH 2 CI 2 /ethyl acetate, 7: 1 2) to afford 6.3 g (83% yield) of 2-methylthιo-4-chloro-5-nιtro-6-(3- (dιmethylamιnocarbonyDphenoxy)pyrιmιdιne, a compound of formula (C) B. In a similar manner, the following compounds of formula (C) are made 2-methylthιo-4-chloro-5-nιtro-6-(3-(dιethylamιnocarbonyl)phenoxy)pyrιmιdιne, 2-methylthιo-4-chloro-5-nιtro-6-(5-methyl-3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne, 2-methylthιo-4-chloro-5-nιtro-6-(5-trιfluoromethyl-3-(dιmethylamιnocarbonyl)phenoxy)pyπmιdιne 2-methylthιo-4-chloro-5-nιtro-6-(5-methoxy-3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne, 2-methylthιo-4-chloro-5-nιtro-6-(5-carboxy-3-(dιmethylamιnocarboπyl)phenoxy)pyrιmιdιne, 2-methylthιo-4-chloro-5-nιtro-6-(5-ethoxycarbonyl-3-methylphenoxy)pyrιmιdιne; 2-methylthιo-4-chloro-5-nιtro-6-(5-dιmethylamιno-3-(ιmιdazolιn-2-yl)phenoxy)pyπmιdιne; 2-methylthιo-4-chloro-5-nιtro-6-(5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol- 2-yl)phenoxy)pyrιmιdιne; 2-methylthιo-4-chloro-5-nιtro-6-(5-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)- phenoxylpyπmidine; and 2-methylthιo-4-chloro-5-nιtro-6-(5-(2-ethoxycarbonylethyl)-3-(tetrahydropyrιmιdιn- 2-yl)phenoxy)pyrιmιdιne. C. In a similar manner, 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6- (2-benzyloxy-5-cyanophenoxy)pyrιmιdιne, a compound of formula (M) , prepared as described below in Preparation 4, is treated with 3-(dιmethylamιnocarbonyl)phenol, a compound of formula (B) to afford 2-(3-dιmethylamιnocarbonylphenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2- benzyloxy-5-cyanophenoxy)pyrιmιdιne, a compound of formula (N) . D. In a similar manner, the following compounds of formula (N) are made: 2-(3-methylphenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-methoxy- 5-cyanophenoxy)pyπmιdιne; 2-(3-chloro-5-methoxyphenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro- 6-(2-ethoxy-5-cyanophenoxy)pyrιmιdιne; 2-(4-trιfluoromethylphenoxy)-4-(ethoxycarbonytmethyl)amιno-5-nιtro-6-(3-methoxy- 5-cyanophenoxy)pyrιmιdιne; 2-(3, 5-dιnιtrophenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-ethoxy- 5-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιno-5-methylphenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-phenoxy- 5-cyanophenoxy)pyrιmιdιne; 2-(3-ureιdophenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-phenoxy- 5-cyanophenoxy)pyrιmιdιne; 2-(3-(2-chloroethyl)-5-methylphenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro- 6-(2-chloro-5-cyanophenoxy)pyrιmιdιne; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro- 6-(3-bromo-5-cyanophenoxy)pyrιmιdιne; 2-(4-ethoxycarbonylphenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-methyl- 5-cyanophenoxy)pyrιmιdιne; 2-(3-( 1 -methylιmιdazol-2-yl)phenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-methyl- 5-cyanophenoxy)pyrιmιdιne; 2-(3-dιmethylamιnophenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-methyl- 4-cyanophenoxy)pyrιmιdιne, 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-nιtro- 5-cyanophenoxy)pyrιmιdιne; 2-(3-f-butoxycarbonylphenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-nιtro- 4-cyanophenoxy)pyπmιdιne; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro- 6-(2-carboxy-5-cyanophenoxy)pyrιmιdιne; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro- 6-(3-carboxy-4-cyanophenoxy)pyrιmιdιne; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(ethoxycarbonylmethyl)ammo-5-nιtro- 6-(2-f-butoxycarbonyl-5-cyanophenoxy)pyrιmιdιne; 2-(3-(1 -methylιmιdazolιn-2-yl)phenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro- 6-(3-?-butoxycarbonyl-4-cyanophenoxy)pyrιmιdιne; 2-(3-(1 -methylιmιdazolιn-2-yl)phenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro- 6-(2-amιnocarbonyl-5-cyanophenoxy)pyπmιdιne; 2-(3-(1 -methγlιmιdazolιπ-2-yl)phenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro- 6-(3-amιnocarbonyl-4-cyanophenoxy)pyrιmιdιne; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro- 6-(2-dιmethylamιno-5-cyanophenoxy)pyrιmιdιπe; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro- 6-(3-dιmethylamιno-4-cyanophenoxy)pyπmιdιne; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro- 6-(2-dιmethylamιno-5-cyanophenoxy)pyrιmιdιne; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro- 6-(3-dιmethylamιno-4-cyanophenoxy)pyrιmιdιne; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-amιno-5-nιtro-6-(2-methoxy-5 cyanophenoxylpyπmidine; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-amιno-5-nιtro-6-(2-ethoxy-5-cyanophenoxy)pyrιmιdιne; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-amιno-5-nιtro-6-(3-methoxy-5- cyanophenoxy)pyπmidιne; 2-(3-( 1 -methyiιmιdazolιn-2-yl)phenoxy)-4-amιno-5-nιtro-6-(3-ethoxy-5-cyanophenoxy)pyrιmιdιne, 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-amιno-5-nιtro-6-(2-phenoxy-5- cyanophenoxy)pyrimιdιne; 2-(3-dιmethylamιnocarbonylphenoxy)-4-amιno-5-nιtro-6-(3-phenoxy-5-cyanophenoxy)pyrιmιdιne; 2-(3-dιmethylamιnocarbonylphenoxy)-4-amιno-5-nιtro-6-(2-chloro-5-cyanophenoxy)pyrιmιdιne; 2-(3-dιmethylamιnocarbonylphenoxy)-4-amιno-5-nιtro-6-(3-bromo-5-cyanophenoxy)pyrιmιdιne; 2-(3-dιmethylamιnocarbonylphenoxy)-4-amιno-5-nιtro-6-(2-methyl-5-cyanophenoxy)pyπmιdιne, 2-(3-dιmethylamιnocarbonylphenoxy}-4-amιno-5-nιtro-6-(2-methyl-5-cyanophenoxy)pyrιmιdιne, 2-(3-dιmethylamιnocarbonylphenoxy)-4-amιno-5-nιtro-6-(3-methyl-4-cyanophenoxy)pyπmιdιπe, 2-(3-dιmethylamιnocarbonylphenoxy)-4-amιno-5-nιtro-6-(2-nιtro-5-cyanophenoxy)pyrιmιdιne, 2-(3-dιmethylamιnocarbonylphenoxy)-4-amιno-5-nιtro-6-(3-nιtro-4-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιnophenoxy)-4-amιno-5-nιtro-6-(2-carboxy-5-cyanophenoxy)pyrιmιdιne, 2-(3-guanιdιnophenoxy)-4-amιno-5-nιtro-6-(3-carboxy-4-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιnophenoxy)-4-amιno-5-nιtro-6-(2-f-butoxycarbonyl-5-cyanopheπoxy)pyrιmιdιne; 2-(3-guanιdιnophenoxy)-4-amιno-5-nιtro-6-(3-f-butoxycarbonyl-4-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιnophenoxy)-4-amιno-5-nιtro-6-(2-amιnocarbonyl-5-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιnophenoxy)-4-amιno-5-nιtro-6-(3-amιnocarbonyl-4-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιnophenoxy)-4-amιno-5-nιtro-6-(2-dιmethylamιno-5-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιnophenoxy)-4-amιno-5-nιtro-6-(3-dιmethylamιno-4-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιnophenoxy)-4-amιno-5-nιtro-6-(2-dιmethylamιno-5-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιnophenoxy)-4-amιno-5-nιtro-6-(3-dιmethylamιno-4-cyanophenoxy)pyrιmιdιne; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(1 -carboxyethyl)amιno-5-nιtro-6-(3-bromo- 5-cyanophenoxy)pyrιmidιne; 2-(3-dιmethylamιnocarbonylphenoxy)-4-( 1 -carboxy-2-methylpropyl)amιno-5-nιtro-6-( 2-methyl- 5-cyanophenoxy)pyrιmιdine; 2-(3-dιmethylamιnocarbonylphenoxy)-4-( 1 -carboxy-3-methylbutyl)amιno-5-nιtro-6-(2-methyl- 5-cyanophenoxy)pyrιmιdιne; 2-(3-dιmethγlamιnocarbonylphenoxy)-4-( 1 -carboxy-2-methylbutyl)amιno-5-nιtro-6-(3-methyl- 4-cyanophenoxy)pyrιmιdιne; 2-(3-dιmethylamιnocarbonylphenoxy)-4-( 1 -carboxy-2-phenylethyl)amιno-5-nιtro-6-(2-nιtro- 5-cyanophenoxy)pyrιmιdιne; 2-(3-dιmethylamιnocarbonylphenoxy)-4-( 1 -carboxy-2-(4-mercaptophenyl)ethyl)amιno-5-nιtro- 6-(3-nιtro-4-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιnophenoxy)-4-( 1 -carboxy-3-(methylthιo)propyl)amιno-5-nιtro-6-(2-carboxy- 5-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιnophenoxy)-4-(1 -carboxy-2-(ιmιdazol-4-yl)ethyl)amιno-5-nιtro-6-(3-carboxy- 4-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιnophenoxy)-4-( 1 -carboxy- 2-hydroxyethyl)ammo-5-nιtro-6-(2-f-butoxycarbonyl- 5-cyanophenoxy)pyrιmιdιne; 2-(3-guaπιdιnophenoxy)-4-( 1 -carboxy-2-hydroxypropyl)amιno-5-nιtro-6-(3-f-butoxycarboπyl- 4-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιnophenoxy)-4-( 1 -carboxy-2-(amιnocarbonyl)ethyl)amιno-5-nιtro-6-(2-amιnocarbonyl- 5-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιnophenoxy)-4-( 1 -carboxy-3-(amιnocarbonyl)propyl)amιno-5-nιtro-6-(3-amιnocarbonyl- 4-cyanophenoxy)pyrιmιdιπe; 2-(3-guanιdιnophenoxy)-4-(1 ,2-dιcarboxyethyl)amιno-5-nιtro-6-(2-dιmethylamιno- 5-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιπophenoxy)-4-( 1 , 3-dιcarboxypropyl)amιno-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy)ρyrιmιdιne; 2 (3-guanιdιπophenoxy)-4-( 1 -carboxy-5-amιnopentyl)amιno-5-nιtro-6-(2-dιmethylamιno- 5-cyanophenoxy)pyrιmιdιne, and 2-(3-guanιdιnophenoxy)-4-( 1 -carboxy-4-guanιdιnobutyl)amιno-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy)pyrιmιdιne. E. In a similar manner, 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nιtro- 6-(2-benzyloxy-5-cyanophenoxy)pyrιmιdιne, a compound of formula (V), is treated with 3- (dιmethylamιnocarbonyl)phenol, a compound of formula (B), to afford 2-(3-dιmethyl- amιnocarbonylphenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-benzyloxy-5-cyano- phenoxylpyπmidine, a compound of formula (W) . F. In a similar manner, the following compounds of formula (W) are prepared: 2-(3-methylphenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-methoxy- 5-cyanophenoxy)pyrιmιdιne; 2-(3-chloro-5-methoxyphenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro- 6-(2-ethoxy-5-cyanophenoxy)pyrιmιdιne; 2-(4-trιfluoromethylphenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-methoxy- 5-cyanoρhenoxy)pyπmιdιne; 2-(3,5-dιnιtrophenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-ethoxy- 5-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιno-5-methylphenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-phenoxy- 5-cyaπophenoxy)pyrιmιdιne; 2-(3-ureιdophenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-phenoxy- 5-cyanophenoxy)pyrιmιdιne; 2-(3-(2-chloroethyl)-5-methylphenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro- 6-(2-chloro-5-cyanophenoxy)pyrιmιdιne; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro- 6-(3-bromo-5-cyanophenoxy)pyrιmιdιne; 2-(4-ethoxycarbonylphenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-methyl- 5-cyanophenoxy)pyrιmιdιne; 2-(3-( 1 -methylιmιdazol-2-yl)phenoxy)-4-(ethoxycarbonyl)methoxy 5-nιtro-6-(2 methyl- 5-cyanophenoxy)pyrιmιdιne; 2-(3-dιmethylamιnophenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3 methyl- 4-cyanophenoxy)pyrιmιdιne; 2-(3 (1 -methylιmιdazolιn-2-yl)phenoxy-4-(ethoxycarbonyl)methoxy-5-nιtro-6 (2-nιtro- 5-cyanophenoxy)pyrιmιdιne; 2-(3-f-butoxycarbonylphenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-nιtro- 4-cyanophenoxy)pyrιmιdιne; 2-(3-( 1 -methylιmιdazolm-2-yl)phenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro- 6-(2-carboxy-5-cyanophenoxy)pyπmιdιne; 2-( 3-( 1 -methylιmιdazolιn-2-yl)ρhenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro- 6-(3-carboxy-4-cyanophenoxy)pyrιmιdιne, 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6- (2-r-butoxycarbonyl-5-cyanophenoxy)pyπmιdιne, 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6- (3-^-butoxycarbonyl-4-cyanophenoxy)pyrιmιdιne; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-amιnocarbonyl- 5-cyanophenoxy)pyrιmιdιne; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro 6-(3-amιnocarbonyl- 4-cyanophenoxy)pyrιmιdιne; 2-(3-(1 -methylιmιdazolιn-2-yl)phenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-dιmethylamιno- 5-cyanophenoxy)pyrιmιdιne; 2-(3-( 1 methylιmιdazolιn-2-yl)phenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy)pyrιmιdιne, 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6 (2-dιmethylamιno- 5-cyanophenoxy)pyrιmιdιne; 2 (3-( 1 -methylιmιdazoiιn-2-yl)phenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3 dimethylamino 4-cyaπophenoxy)pyrιmιdιne; 2-(3-dιmethylamιnocarbonylphenoxy)-4-( 1 -carboxyethoxy)-5-nιtro-6-(3-bromo- 5-cyanophenoxy) pyrimidine; 2-(3-dιmethylamιnocarbonylphenoxy)-4-( 1 -carboxy-2-methylpropoxy)-5-nιtro-6-( 2-methyl- 5-cyanophenoxy)pyrιmιdιne; 2-(3-dιmethylamιnocarbonylphenoxy)-4-( 1 -carboxy-3-methylbutoxy)-5-nιtro-6-(2-methyl- 5-cyanophenoxy)pyrιmιdine; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(1 -carboxy-2-methylbutoxy)-5-nιtro-6-(3-methyl- 4-cyanophenoxy)pyrιmιdιne; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(1 -carboxy-2-phenylethoxy)-5-nιtro-6-(2-nιtro- 5-cyanophenoxy)pyrιmιdιne; 2-(3-dιmethylamιnocarbonylphenoxy)-4-( 1 -carboxy-2-(4-mercaptophenyl)ethoxy)-5-nιtro- 6-(3-nιtro-4-cyanophenoxy)pyrιmidιne; 2-(3-guanιdιnophenoxy)-4-( 1 -carboxy-3-(methylthιo)propoxy)-5-nιtro-6-(2-carboxy- 5-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιnophenoxy)-4-(1 -carboxy-2-(ιmιdazol-4-yl)ethoxy)-5-nιtro-6-(3-carboxy- 4-cyanophenoxy)pyrιmιdιne; 2-(3-guanιdιnophenoxy)-4-( 1 -carboxy-2-hydroxyethoxy)-5-πιtro-6-(2-r-butoxycarbonyl- 5-cyanophenoxy)pyπmιdιne; 2-(3-guanιdιnophenoxy)-4-( 1 -carboxy-2-hydroxypropoxy)-5-nιtro-6-(3-r-butoxycarbonyl- 4-cyanophenoxy)pyrιmιdine; 2-(3-guanιdιnophenoxy)-4-( 1 -carboxy-2-(amιnocarbonyl)ethoxy)-5-πιtro-6-(2-amιnocarbonyl- 5-cyanophenoxy) pyrimidine; 2-(3-guanιdιnophenoxy)-4-(1 -carboxy-3-(amιnocarbonyl)propoxy)-5-nιtro-6-(3-amιnocarbonyl- 4-cyanophenoxy)pyrιmιdine; 2-(3-guanιdιnophenoxy)-4-( 1 ,2-dιcarboxyethoxy)-5-nιtro-6-(2-dιmethylamιno- 5-cyanophenoxy (pyrimidine; 2-{3-guanιdιnophenoxy)-4-( 1 ,3-dicarboxypropoxy)-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy (pyrimidine; 2-(3-guanιdιnophenoxy)-4-( 1 -carboxy-5-amιnopentoxy)-5-nιtro-6-(2-dιmethylamιno- 5-cyanophenoxy)pyrιmidine; and 2-(3-guanιdιnophenoxy)-4-(1 -carboxy-4-guanιdιnobutoxy)-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy) pyrimidine. PREPARATION 2 Compounds of formula (E) and formula (L) A. To 2-methylthιo-4-chloro-5-nιtro-6-(3-(dιmethyiamιnocarbonyl)phenoxy(- pyπmidine, a compound of formula (C), (3.0 g 8 1 4 mmol) in 80 mL of acetonitrile at 0°C was added glycine ethyl ester hydrochloπde, a compound of formula (D) , ( 1 .1 g, 8 14 mmol), followed by the addition of cesium carbonate (6.1 g, 18.7 mmol) The reaction mixture was allowed to warm to ambient temperature and then stirred for 2 hours. The volatiles were evaporated to yield 3.6 g of 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3- (dιmethylamιnocarbonyl)-phenoxypyrιmιdιne, a compound of formula (E) . B. In a similar manner, the following compounds of formula (E) are prepared: 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-(dιethylamιnocarbonyl(- phenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-methyl-3-(dιmethyl- amιnocarbonyl)phenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-trιfluoromethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne, 2-methylthιo-4-|ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-methoxy- 3-(dιmethylamιnocarbonyl)pheπoxy (pyrimidine, 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-( 5-carboxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyπmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-ethoxycarbonyl- 3-methylphenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-dιmethylamιno-3-(ιmιdazolιn- 2-yl)phenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-(dιmethylamιnocarbonyl)methyl- 3-(ιmιdazol-2-yl)phenoxy (pyrimidine; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-(2-ethoxycarbonylethyl(- 3-(tetrahydropyrιmιdιn-2-yl)phenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxyethyl)amιno-5-nιtro-6-(3-(dιethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-2-methylpropyl)amιno-5-nιtro-6-(5-methyl-3-(dιmethyl- aminocarbonyllphenoxylpyπmidine; 2-methylthιo-4-( 1 -carboxy-3-methylbutyl)amιno-5-nιtro-6-( 5-trιfluoromethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyπmιdιne; 2-methylthιo-4-( 1 -carboxy-2-methylbutyl)amιno-5-nιtro-6-(5-methoxy- 3-(dtmethylamιnocarbonyl)phenoxy)pyrιmιdιne, 2-methylthιo-4-( 1 -carboxy-2-phenylethyl)amιno-5-nιtro-6-( 5-carboxy- 3-(dιmethylamιnocarbonyl(phenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-2-(4-mercaptophenyl)ethyl)amιno-5-nιtro-6-( 5-ethoxycarbonyl- 3-methylphenoxy)pyπmιdιne, 2-methylthιo-4-( 1 -carboxy-3-(methylthιo)propyl)amιno-5-nιtro-6-(5-dιmethylamιno-3-(ιmιdazolιn- 2-yl(phenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-2-mercaptoethyl)amιno-5-nιtro-6-(5-(dιmethylamιnocarbonyl)methyl- 3-(ιmιdazol-2-yl)phenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-2-(ιndolιn-3-yl)ethyl)amιno-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-2-(ιmιdazol-4-yl)ethyl)amιno-5-nιtro-6-(5-(2-ethoxycarbonylethyl(- 3-(tetrahydropyrιmιdιn-2-yl)phenoxy)pyrιmιdιne; 2-methylthιo-4-(1 -carboxy-2-hydroxyethyl)amιno-5-nιtro-6-(5-carboxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne, 2-methylthιo-4-( 1 -carboxy-2-hydroxypropyl)amιno-5-nιtro-6-(5-ethoxycarbonyl- 3-methylphenoxy)pyπmιdιne, 2-methylthιo-4-( 1 -carboxy-2-(amιnocarbonyl)ethyl)amιno-5-nιtro-6-(5-dιmethylamιno- 3-(ιmιdazolιn-2-yl)phenoxy)pyrιmιdιne, 2-methylthιo-4-( 1 -carboxy-3-(amιnocarbonyl)propyl)amιno-5-nιtro-6-(5-(dιmethylamιnocarbonyl)- methyl-3-(ιmιdazol-2-yl)phenoxy)pyrιmtdιne; 2-methylthιo-4-( 1 ,2-dιcarboxyethyl)amιno-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 ,3-dιcarboxypropyl)amιno-5-nιtro-6-(5-(2-ethoxycarbonylethyl(- 3-(tetrahydropyrιmιdιn-2-yl)phenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 carboxy-5-amιnopentyl)amιno-5-nιtro-6-(5-(dιmethylamιnocarbonyl)methyl- 3-<ιmιdazol-2-yl)phenoxy)pyπmιdιne; and 2 methylthιo-4-( 1 -carboxy-4-guanιdιnobutyl)amιno-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne. C. In a similar manner, 2-methylthιo-4-chloro-5-nιtro-6-(2-benzyloxy- 5-cyanophenoxy)pyrιmιdιne, a compound of formula (K), is treated with glycine ethyl ester hydrochloride, a compound of formula (D), to yield 2-methylthιo-4-(ethoxycarbonylmethyl)amιno- 5-nιtro-6-(2-benzyloxy-5-cyanophenoxy)pyrιmιdιne, a compound of formula (L) . D. In a similar manner, the following compounds of formula (L) are prepared * 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-methoxy-5-cyanophenoxy)pyrιmιdιne, 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-ethoxy-5-cyanophenoxy (pyrimidine; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-methoxy-5 cyanophenoxy (pyrimidine, 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-ethoxy-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl}amιno-5-nιtro-6-(2-phenoxy-5-cyanophenoxy)pyrιmιdιne, 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-phenoxy-5-cyanopheπoxy (pyrimidine, 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-chloro-5-cyanophenoxy)pyrιmιdιne, 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-bromo-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-methyl-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-methyl-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-methyl-4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-nιtro-5-cyanophenoxy)pyrιmιdme; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-nιtro-4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-carboxy-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-carboxy-4-cyanophenoxy)pyπmιdιne, 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-f-butoxycarbonyl- 5-cyanophenoxy)pyrιmιdine; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-r-butoxycarbonyl- 4-cyanophenoxy(pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-amιnocarbonyl- 5-cyanophenoxy) pyrimidine; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-amιnocarbonyl- 4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-πιtro-6-(2-dιmethylamιno- 5-cyanophenoxy(pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-dιmethylamιno- 5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(2-methoxy-5-cyanophenoxy)pyπmιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(2-ethoxy-5-cyanophenoxy (pyrimidine; 2-methylthιo-4-amino-5-nιtro-6-(3-methoxy-5-cyanophenoxy)pyπmιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(3-ethoxy-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(2-phenoxy-5-cyanophenoxy)pyπmιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(3-phenoxy-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(2-chloro-5-cyanophenoxy)pyπmιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(3-bromo-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(2-methyl-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(2-methyl-5-cyanophenoxy (pyrimidine; 2-methylthιo-4-amιno-5-nιtro-6-(3-methyl-4-cyanophenoxy (pyrimidine; 2-methylthιo-4-amιno-5-nιtro-6-(2-nιtro-5-cyanophenoxy)ρyrιmιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(3-nιtro-4-cyanophenoxy (pyrimidine; 2-methylthιo-4-amιno-5-nιtro-6-(2-carboxy-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(3-carboxy-4-cyanophenoxy)pyπmιdιπe; 2-methylthιo-4-amιno-5-nιtro-6-(2-f-butoxycarbonyl-5-cyanophenoxy)pyrιr * nιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(3-f-butoxycarbonyl-4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(2-amιnocarbonyl-5-cyanoρhenoxy)pyrιmιdme; 2-methylthιo-4-amιno-5-nιtro-6-(3-amιnocarbonyl-4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(2-dιmethylamιno-5-cyanopheπoxy)pyrιmιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(3-dιmethylamιno-4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(2-dιmethylamιno-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-amιno-5-nιtro-6-(3-dιmethylamιno-4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxyethyl)amιno-5-nιtro-6-(3-bromo-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-2-methylpropyl)amιno-5-nιtro-6-(2-methyl-5-cyanophenoxy)pyrιmιdιne, 2-methylthιo-4-( 1 -carboxy-3-methylbutyl)amιno-5-nιtro-6-(2-methyl-5-cyanophenoxy)pyrιmιdιne, 2-methylthιo-4-( 1 -carboxy-2-methylbutyl)amιno-5-nιtro-6-(3-methyl-4-cyanophenoxy)pyrιmιdιne, 2-methylthιo-4-(1 -carboxy-2-phenylethyl)amιno-5-nιtro-6-(2-nιtro-5-cyanophenoxy)pyrιmιdιne, 2-methylthιo-4-( 1 -carboxy-2-(4-mercaptophenyl)ethyl)amιno-5-nιtro-6-(3-nιtro- 4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-3-(methylthιo)propyl)amιno-5-nιtro-6-(2-carboxy- 5-cyanophenoxy)pyπmιdιne; 2-methylthιo-4-( 1 -carboxy-2-(ιmιdazol-4-yl)ethyl)amιno-5-nιtro-6-(3-carboxy- 4-cyanopheπoxy)pyπmιdιne; 2-methylthιo-4-(1 -carboxy-2-hydroxyethyl)amιno-5-nιtro-6-(2-f-butoxycarbonyl- 5-cyanophenoxy)pyπmιdιne; 2-methylthιo-4-( 1 -carboxy-2-hydroxypropyl)amιno-5-nιtro-6-(3-f-butoxycarbonyl- 4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-2-(amιnocarbonyl)ethyl)amιno-5-nιtro-6-(2-amιnocarbonyl- 5-cyanophenoxy)pyπmιdιne; 2-methylthιo-4-( 1 -carboxy-3-(amιnocarbonyl)propyl)amιno-5-nιtro-6-(3-amιnocarbonyl- 4-cyanophenoxy)pyπmιdιne; 2-methylthιo-4-(1 ,2-dιcarboxyethyl)amιno-5-nιtro-6-(2-dιmethylamιno-5- cyanophenoxylpyπmidine; 2-methylthιo-4-(1 ,3-dιcarboxypropyl)amιno-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-5-amιnopentyl)amιno-5-nιtro-6-(2-dιmethylamιno- 5-cyanophenoxy)pyrιmιdιne; and 2-methylthιo-4-(1 -carboxy-4-guanιdιnobutyl)amιno-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy)pyrιmιdιne. PREPARATION 3 Compounds of formula (Q) and (U) A. To sodium hydride (0.63 g, 1 5.72 mmol) in 30 mL tetrahydrofuran at 0°C was added ethyl glycolate ( 1 .1 5 mL, 1 2.09 mmol) over 10 minutes. The resulting alkoxide was then added to 2-methylthio-4-ch!oro-5-nιtro-6-(3-dimethylamιnocarbonylphenoxy)pyrimidine, a compound of formula (C), (4.46 g., 1 2.09 mmol) , dropwise at 0°C over 5 minutes. After 1 hours, the reaction mixture was warmed to ambient temperature and stirred for an additional 2 hours. The volatiles were evaporated to yield 2.55 g (48% yield) of 2-methylthio-4- (ethoxycarbonyl)methoxy-5-nιtro-6-(3-dιmethylamιnocarbonylphenoxy)pyπmιdine, a compound of formula (Q), as a yellow oil. B. In a similar manner, the following compounds of formula (Q) are prepared: 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-(dιethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-methyl-3-(dιmethyl- ammocarbonyUphenoxy (pyrimidine; 2-methylthio-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-trιfluoromethyl- 3-(dιmethylamιnocarbonyl)phenoxy (pyrimidine; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-methoxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιrnidine; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-carboxy- 3-(dimethylamιnocarbonyl)phenoxy)pyrιmidιne; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-ethoxycarbonyl- 3-methylphenoxy)pyrimidine; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-dιmethylamιno-3-(ιmιdazolιn- 2-yl)phenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-(dιmethylamιnocarbonyl)methyl- 3-(imιdazol-2-yl)phenoxy)pyπmιdine; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrimidine; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-πιtro-6-(5-{2-ethoxycarbonylethyl(- 3-(tetrahydropyrιmιdin-2-yl)phenoxy)pyπmidιne; 2-methylthιo-4-( 1 -carboxyethoxy)-5-πιtro-6-(3-(dιethylamιnocarbonyl)phenoxy)ρyπmιdιne; 2-methylthιo-4-( 1 -carboxy-2-methylpropoxy)-5-nιtro-6-(5-methyl-3-(dimethyl- ammocarbonyDphenoxy (pyrimidine; 2-methylthιo-4-( 1 -carboxy-3-methylbutoxy)-5-nιtro-6-(5-trιfluoromethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmidιne; 2-methylthιo-4-( 1 -carboxy-2-methylbutoxy)-5-nιtro-6-(5-methoxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-2-phenylethoxy)-5-nιtro-6-(5-carboxy- 3-(dιmethylamιnocarbonyi)phenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-2-(4-mercaptophenyl)ethoxy) 5-nιtro-6-(5-ethoxycarbonyl- 3-methylphenoxy)pyπmιdιne; 2-methylthιo-4-( 1 -carboxy-3-(methylthιo)propoxy)-5-nιtro-6-(5-dιmethylamιno-3-(ιmιdazolιn- 2-yl)phenoxy)pyrιmιdιπe; 2-methylthιo-4-( 1 -carboxy-2-mercaptoethoxy)-5-nιtro-6-(5-(dιmethylamιnocarbonyl)methyl- 3-(ιmιdazol-2-yl)phenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-2-(ιndolιn-3-yl)ethoxy)-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-2-(ιmιdazol-4-yl(ethoxy)-5-nιtro-6-(5-(2-ethoxycarbonylethyl(- 3-(tetrahydropyrιmιdιn-2-yl)phenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-2-hydroxyethoxy)-5-nιtro-6-(5-carboxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyπmιdιne; 2-methylthιo-4-( 1 -carboxy-2-hydroxypropoxy)-5-nιtro-6-(5-ethoxycarbonyl- 3-methylphenoxy) pyrimidine; 2-methylthιo-4-( 1 -carboxy-2-(amιnocarbonyl)ethoxy)-5-nιtro-6-(5-dιmethylamιno-3-(ιmιdazolιn- 2-yl)phenoxy (pyrimidine; 2-methylthιo-4-( 1 -carboxy-3-(amιnocarbonyl(propoxy)-5-nιtro-6- (5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 ,2-dιcarboxyethoxy)-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyπmidιne; 2-methylthιo-4-( 1 ,3-dιcarboxypropoxy)-5-nιtro-6-(5-(2-ethoxycarbonylethyl) 3-(tetrahydropyrιmιdιn-2-yl)phenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-5-amιnopentoxy)-5-nιtro-6-(5-(dιmethylamιnocarbonyl)methyl- 3-(ιmιdazol-2-yl)phenoxy)pyrιmιdιne; and 2-methylthιo-4-( 1 -carboxy-4-guanιdιnobutoxy)-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne. C. In a similar manner, 2-methylthιo-4-chloro-5-nιtro-6-(2-benzyloxy- 5-cyanophenoxy)pyrιmιdιne, a compound of formula (K), is treated with ethyl glycolate, a compound of formula (P), to yield 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2- benzyloxy-5-cyanophenoxy)pyrιmιdιne, a compound of formula (U). D. In a similar manner, the following compounds of formula (U) are prepared 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-methoxy-5-cyanophenoxy (pyrimidine; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-ethoxy-5-cyanophenoxy (pyrimidine; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-methoxy-5-cyanophenoxy)pyπmιdιne; 2-methylthιo-4-(ethoxycarboπyl)methoxy-5-nιtro-6-(3-ethoxy-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-phenoxy-5-cyanophenoxy)pyrιmιdιne, 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-phenoxy-5-cyanophenoxy)pyπmιdιne, 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-chloro-5-cyanophenoxy)pyrιmιdιne, 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-bromo-5-cyanophenoxy)pyπmιdιne, 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-methyl-5-cyanophenoxy (pyrimidine; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-methyl-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-methyl-4-cyanophenoxy (pyrimidine; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-nιtro-5-cyanophenoxy (pyrimidine, 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-nιtro-4-cyanophenoxy) pyrimidine, 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-carboxy-5-cyanophenoxy)pyπmιdιne; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-carboxy-4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonyi)methoxy-5-nιtro-6-(2-f-butoxycarbonyl- 5-cyanophenoxy)pyrιmιdιne, 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-f-butoxycarbonyl- 4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-πιtro-6-(2-amιnocarbonyl-5-cyanophenoxy)pyrιmιdιne, 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-amιnocarbonyl-4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-dιmethylamιπo-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-dιmethylamιno-4-cyanophenoxy (pyrimidine, 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-dιmethylamιno-5-cyanophenoxy)pyrιmιdιne, 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-dιmethylamιno-4-cyanophenoxy)pyrιmιdιne, 2-methylthιo-4-( 1 -carboxyethoxy)-5-nιtro-6-(3-bromo-5-cyanoρhenoxy (pyrimidine; 2-methylthιo-4-( 1 -carboxy-2-methylpropoxy)-5-nιtro-6-(2-methyl-5-cyanophenoxy (pyrimidine; 2-methylthιo-4-( 1 -carboxy- 3-methylbutoxy)-5-nιtro-6-(2-methyl-5-cyanophenoxy)pyrιmιdιne, 2-methylthιo-4-( 1 -carboxy-2-methylbutoxy)-5-nιtro-6-(3-methyl-4-cyanophenoxy)pyrιmιdιne, 2-methylthιo-4-(1 -carboxy-2-phenylethoxy)-5-nιtro-6-(2-nιtro-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-2-(4-mercaptophenyl)ethoxy)-5-nιtro-6-(3-nιtro- 4-cyanophenoxy (pyrimidine; 2-methylthιo-4-( 1 -carboxy-3-(methylthιo)propoxy)-5-nιtro-6-(2-carboxy- 5-cyanophenoxy)pyπmιdιne; 2-methylthιo-4-( 1 -carboxy-2-(ιmιdazol-4-yl)ethoxy)-5-nιtro-6-(3-carboxy- 4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-( 1 -carboxy-2-hydroxyethoxy)-5-nιtro-6-(2-r-butoxycarbonyl- 5-cyanophenoxy (pyrimidine; 2-methylthιo-4-( 1 -carboxy-2-hydroxypropoxy)-5-nιtro-6-(3-f-butoxycarbonyl- 4-cyanophenoxy)pyrιmιdιne; 2 methylthιo-4-( 1 -carboxy-2-(amιnocarbonyl)ethoxy)-5-nιtro 6-(2-amιnocarbonyl- 5-cyanophenoxy)pyrιmιdine; 2-methylthιo-4-( 1 -carboxy-3-(amιnocarbonyl)propoxy)-5-nιtro-6-(3-amιnocarbonyl- 4-cyanophenoxy (pyrimidine; 2-methylthιo-4-{ 1 ,2-dicarboxyethoxy)-5-nιtro-6-(2-dιmethylamino-5-cyanophenoxy (pyrimidine; 2-methylthιo-4-( 1 , 3-dicarboxypropoxy)-5-nitro-6-(3-dimethylamino-4-cyanophenoxy)pyrιmιdιne; 2-methylthio-4-( 1 -carboxy-5-aminopentoxy)-5-nitro-6-(2-dimethylamino- 5-cyanophenoxy)pyrimιdine; and 2-methylthιo-4-( 1 -carboxy-4-guanιdιnobutoxy)-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy)pyrimιdine. PREPARATION 4 Compounds of formula (F), formula (M), formula (R) and Formula (V) A. To 2-methylthιo-4-(ethoxycarbonylmethyl)amino-5-nιtro-6-(3- (dιmethylamιnocarbonyl)phenoxypyrιmιdιne, a compound of formula (E) , (3.54 g, 8. 1 4 mmol) in 40 mL methanol at 0°C was added potassium metabisulfite (7.5 g, 24.4. mmol) in 40 mL water. The resulting suspension was allowed to warm to ambient temperature and stirred for 1 5 hours. The reaction mixture was concentrated to about 25 mL and extracted with methylene chloride (200 mL) . The organic layer was dried (Na 2 S0 4 ) and evaporated to afford 3.5 g of 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amino-5-nιtro-6-(3-(dimethylamιnocarbonyl(- phenoxypyπmidine, a compound of formula (F), as a white solid. B. In a similar manner, the following compounds of formula (F) are prepared: 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amino-5-nιtro-6-(3-(diethylamιno- carbonyDphenoxyJpyrimidine; 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amino-5-nιtro-6-{5-methyl-3-(dιmethyl- amιnocarbonyl)phenoxy)pyrιmidine; 2-methylsulfoπyl-4-(ethoxycarbonylmethyl)amιno-5-nitro-6-(5-trιfluoromethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrimidine; 2-methylsulfony!-4-(ethoxycarbonylmethyl)amino-5-nitro-6-(5-methoxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyrimidine; 2-methylsulfonyl-4-{ethoxycarbonylmethyl)amino-5-nιtro-6-(5-carboxy- 3-(dimethylaminocarbonyl)phenoxy)pyrimidine; 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amino-5-nιtro-6-(5-ethoxycarbonyl- 3-methylphenoxy)pyrimidine; 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amino-5-nitro-6-(5-dimethylamιno-3-(ιmιdazolιn- 2-yl(phenoxy)pyrιmidine; 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-(dιmethylamιnocarbonyl)methyl- 3-(ιmιdazol-2-yl)phenoxy)pyrimιdine; 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl|phenoxy (pyrimidine; 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-(2-ethoxycarbonylethyl(- 3-(tetrahydropyrιmιdιn-2-yl)phenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 -carboxyethyl)amιno-5-nιtro-6-(3- (dιethylamιnocarbonyl(phenoxy)pyπmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-2-methylpropyl)amιno-5-nιtro-6-(5-methyl-3-(dιmethyl- aminocarbonyDphenoxy (pyrimidine; 2-methylsulfonyl-4-( 1 -carboxy-3-methylbutyl)amιno-5-nιtro-6-(5-tπfluoromethyl- 3-(dιmethylamιπocarbonyl)phenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-2-methylbutyl)amιno-5-nιtro-6-(5-methoxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-2-phenylethyl)amιno-5-nιtro-6-(5-carboxy- 3-(dιmethylamιnocarbonyl)phenoxy) pyrimidine; 2-methylsulfonyl-4-( 1 -carboxy-2-(4-sulfonylphenyl)ethyl)amιno-5-nιtro-6-( 5-ethoxycarbonyl- 3-methylphenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-3-(methylsulfonyl)propyl)amιno-5-nιtro-6-(5-dιmethylamιno- 3-(ιmιdazolιn-2-yl)phenoxy)pyrιmιdιne; 2-methylsulfonyl-4-(1 -carboxy-2-sulfonylethyl)amιno-5-nιtro-6-(5-(dιmethylamιnocarbonyl)methyl- 3-(ιmιdazol-2-yl)phenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-2-(ιndolιn-3-yl)ethyl)amιno-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-2-(ιmιdazol-4-yl)ethyl)amιno-5-nιtro-6-(5-(2-ethoxycarbonylethyl)- 3-(tetrahydropyπmιdιn-2-yl)phenoxy)pyπmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-2-hydroxyethyl(amιno-5-πιtro-6-(5-carboxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-2-hydroxypropyl)amιno-5-nιtro-6-(5-ethoxγcarbonyl- 3-methylphenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-2-(amιnocarbonyl)ethyl)amιno-5-nιtro-6-(5-dιmethylamιno- 3-(ιmιdazolιn-2-yl)phenoxy)pyπmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-3-(amιnocarbonyl)propyi)amιno-5-nιtro- 6-(5-(dιmethyiamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 ,2-dιcarboxyethyl(amιno-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonγl)phenoxy)pyrιmιdιne; 2-methylsulfonγl-4-( 1 ,3-dιcarboxypropyl)amιno-5-nιtro-6-(5-(2-ethoxγcarbonylethyl(- 3-(tetrahydropyrιmιdιn-2-yl)phenoxy)pyπmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-5-amιnopentyl)amιno-5-nιtro-6-( 5-(dιmethylamιnocarbonyl)methyl- 3-(ιmιdazol-2-yl)phenoxy (pyrimidine; and 2-methylsulfonyl-4-( 1 -carboxy-4-guanιdιnobutyl)amιno-5-nιtro-6-( 5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyπmιdιne. C. In a similar manner, 2-methylthιo-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2- benzyloxy-5-cyanophenoxy)pyrιmιdιne, a compound of formula (L), was oxidized to afford 2- methylsulfonyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-benzyloxy-5- cyanophenoxγ)pyπmιdιne, a compound of formula (M) . D. In a similar manner, the following compounds of formula (M) are prepared. 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-methoxy- 5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro- 6-(2-ethoxy-5-cyanophenoxy)pyrιmιdιne; 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-methoxy- 5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-ethoxy- 5-cyanophenoxy (pyrimidine; 2-methylsulf onyl-4-(ethoxycarbonyl methyl )amιno-5-nιtro-6-(2-phenoxy- 5-cyaπophenoxy(pyrιmιdιne; 2-methylsulf onyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-phenoxy- 5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-chloro-5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-bromo-5-cyanophenoxy)pyrιmιdιne, 2-methylsulf onyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-methyl- 5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-methyl- 5-cyanophenoxy (pyrimidine; 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-methyl- 4-cyanophenoxy)pyrιmιdιne; 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-nιtro-5-cyanophenoxy)pyrιmιdιne; 2-methylsulfonyl-4-(ethoxγcarbonylmethyl)amιno-5-nιtro-6-(3-nιtro-4-cyanophenoxy)pyrιmιdιne; 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-carboxy- 5-cyanoρhenoxy (pyrimidine; 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-carboxy- 4-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-f-butoxycarbonyl- 5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-f-butoxycarbonyl- 4-cyanophenoxy (pyrimidine; 2-methylsulf onyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-amιnocarbonyl 5-cyanophenoxy (pyrimidine; 2-methylsulfonyl-4-(ethoxycarbonylmethyl(amιno-5-nιtro-6-(3-amιnocarbonyl- 4-cyanophenoxy)pyrιmιdιne; 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-dιmethylamιno- 5-cyanophenoxy (pyrimidine; 2-methylsulfonyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy)pyπmιdιne; 2-methylsulf onyl-4-(ethoxycarbonylmethyl(amιno-5-nιtro-6-( 2-dιmethyiamιno- 5-cyanophenoxy (pyrimidine; 2-methylsulf onyl-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy (pyrimidine; 2-methylsulf onyl-4-amιno-5-nιtro-6-(2-methoxy-5-cyanophenoxy (pyrimidine 2-methylsulf onyl-4-amιno-5-nιtro-6-(2-ethoxy-5-cyanophenoxy) pyrimidine, 2-methylsulf onyl-4-amιno-5-nιtro-6-(3-methoxy- 5-cyanophenoxy (pyrimidine, 2-methylsulf onyl-4-amιno-5-nιtro-6-(3-ethoxy-5-cyanophenoxy)pyπmιdιne, 2-methylsulfonyl-4-amιno-5-nιtro-6-(2-phenoxy-5-cyaπophenoxy)pyrιmιdιne, 2-methylsulf onyl-4-amιno-5-nιtro-6-(3-phenoxy-5-cyanophenoxy)pyπmιdιne; 2-methylsulfonyl-4-amιno-5-nιtro-6-(2-chloro-5-cyanophenoxy)pyπmιdιne, 2-methylsulf onyl-4-amιno-5-nιtro-6-(3-bromo-5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-amιno-5-nιtro-6-(2-methyl-5-cyanophenoxy)pyrιmιdιne; 2-methylsulfonyl-4-amιno-5-nιtro-6-(2-methyl-5-cyanophenoxy)pyrιmιdιne, 2-methylsulfonyl-4-amιno-5-nιtro-6-(3-methyl-4-cyanophenoxy (pyrimidine; 2-methylsulfonyl-4-amιno-5-nιtro-6-(2-nιtro-5-cyanophenoxy)pyπmιdιne, 2-methylsulf onyl-4-amιno-5-nιtro-6-(3-nιtro-4-cyanophenoxy (pyrimidine, 2-methylsulf onyl-4-amιno-5-nιtro-6-(2-carboxy-5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-amιno-5-nιtro-6-(3-carboxy-4-cyanophenoxy)pynmιdιne, 2-methylsulf onyl-4-amιno-5-nιtro-6-(2-r-butoxycarbonyl-5-cyanophenoxy)pyrιmιdιne, 2-methylsulfonyl-4-amιno-5-nιtro-6-(3-f-butoxycarbonyl-4-cyanophenoxy)pyrιmιdιne; 2-methylsulfonyl-4-amιno-5-nιtro-6-(2-amιnocarbonyl-5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-amιno-5-nιtro-6-(3-amιnocarbonyl-4-cyanophenoxy (pyrimidine; 2-methylsulf onyl-4-amιno-5-nιtro-6-(2-dιmethylamιno-5-cyanopheπoxy)pyrιmιdιne; 2-methylsulfonyl-4-amιno-5-nιtro-6-(3-dιmethylamιno-4-cyanophenoxy (pyrimidine; 2-methylsulf onyl-4-amιno-5-nιtro-6-(2-dιmethylamιno-5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-amιno-5-nιtro-6-(3-dιmethylamιπo-4-cyanophenoxy)pyrιmιdιne, 2-methylsulfonyl-4-( 1 -carboxyethyl)amιno-5-nιtro-6-(3-bromo-5-cyanophenoxy)pyrιmιdιne, 2-methylsulfonyl-4-( 1 -carboxy-2-methylpropyl)amιno-5-nιtro-6-(2-methyl- 5-cyanophenoxy (pyrimidine; 2-methylsulf onyl-4-( 1 -carboxy-3-methylbutyl)amιno-5-nιtro-6-(2-methyl- 5-cyanophenoxy) pyrimidine; 2-methylsulf onyl-4-(1 -carboxy-2-methylbutyl)amιno-5-nιtro-6-(3-methyl- 4-cyanophenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-2-phenylethyl)amιno-5-nιtro-6-(2-nιtro- 5-cyanophenoxy (pyrimidine; 2-methylsulf onyl-4-( 1 -carboxy-2-(4-sulfonylphenyl)ethyl)amιno-5-nιtro- 6-(3-nιtro-4-cyanophenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-3-(methylsulfonyl)propyl)amιno-5-nιtro-6-(2-carboxy- 5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-( 1 -carboxy-2-(ιmιdazol-4-yl)ethyl)amιno-5-nιtro-6-(3-carboxy- 4-cyanophenoxy) pyrimidine; 2-methylsulfonyl-4-( 1 -carboxy-2-hydroxyethyl)amιno-5-nιtro-6-(2-r-butoxycarbonyl- 5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-( 1 -carboxy-2-hydroxypropyl)amιno-5-nιtro-6-(3-f-butoxycarbonyl- 4-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-( 1 -carboxy-2-(amιnocarbonyl)ethyl)amιno-5-nιtro-6-(2-amιnocarbonyl- 5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-(1 -carboxy-3-(amιnocarbonyl)propyl)amιno-5-nιtro-6-(3-amιnocarbonyl- 4-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-( 1 , 2-dιcarboxyethyl)amιno-5-nιtro-6-(2-dιmethylamιno- 5-cyanophenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 ,3-dιcarboxypropyl)amιno-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy)pyrιmιdιne, 2-methylsulf onyl-4-( 1 -carboxy-5-amιnopentyl)amιno-5-nιtro-6-(2-dιmethylamιno- 5-cyanophenoxy)pyrιmιdιne; and 2-methylsulf onyl-4-( 1 -carboxy-4-guanιdιnobutyl)amιno-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy)pyrιmιdιne. E. In a similar manner, 2-methylthιo-4-(ethoxycarbonyl)methoxy-5-nιtro- 6-(3-dιmethylamιnocarbonylphenoxy)pyrιmιdιne, a compound of formula (Q) , was oxidized to afford 2-methylsulfonlyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-dιmethyl- aminocarbonylphenoxyl-pyπmidine, a compound of formula (R) . F. In a similar manner, the following compounds of formula (R) are prepared 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-(dιethylamιnocarbonyl(- phenoxylpyπmidine; 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-methyl 3-(dιmethyl- aminocarbonyDphenoxylpyπmidine, 2-methylsulf onyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-tπfluoromethyl- 3-(dιmethylamιnocarbonyl)phenoxy(pyrιmιdιne; 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-methoxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyπmιdιne; 2-methylsulf onyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-carboxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-methylsulf onyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-ethoxycarbonyl- 3-methylphenoxy)pyrιmιdιne; 2-methylsulf onyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-dιmethylamιno-3-(ιmιdazolιn- 2-yl)phenoxy (pyrimidine; 2-methylsulf onyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-(dιmethylamιnocarbonyl)methyl- 3-(ιmιdazol-2-yl)phenoxy)pyrιmιdιne, 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy (pyrimidine; 2-methylsulf onyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-(2-ethoxycarbonylethyl(- 3-(tetrahydropyrιmιdιn-2-yl)phenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 -carboxyethoxy)-5-nιtro-6-(3-(dιethylamιnocarbonyl)phenoxy)pyrιmιdιne, 2-methylsulfonyl-4-( 1 -carboxy-2-methylpropoxy)-5-nιtro-6-(5-methyl-3-(dιmethyl- aminocarbonyDphenoxylpyπmidine; 2-methylsulf onyl-4-( 1 -carboxy-3-methylbutoxy)-5-nιtro-6-( 5-trιf luoromethyl- 3-(dιmethylamιnocarbonyl)phenoxy (pyrimidine; 2-methylsulfonyl-4-(1 -carboxy-2-methylbutoxy)-5-nιtro-6-(5-methoxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyπmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-2-phenylethoxy)-5-nιtro-6-(5-carboxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-methylsulf onyl-4-( 1 -carboxy-2-(4-sulfonylphenyl)ethoxy)-5-nιtro-6-(5-ethoxycarbonyl- 3-methylphenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-3-(methylsulfonyl)propoxy)-5-nιtro-6-(5-dιmethylamιno- 3-(ιmιdazolιn-2-yl)phenoxy)pyπmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-2-sulfonylethoxy)-5-nιtro-6-(5-(dιmethylamιnocarbonyl)methyl- 3-(ιmιdazol-2-yl)phenoxy)pyrtmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-2-(ιndolιn-3-yl)ethoxy)-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-2-(ιmιdazol-4-yl)ethoxy)-5-nιtro-6-(5-(2-ethoxycarbonylethyl(- 3-(tetrahydropyrιmιdιn-2-yl)phenoxy (pyrimidine; 2-methylsulfonyl-4-( 1 -carboxy-2-hydroxyethoxy)-5-nιtro-6-(5-carboxy- 3-(dιmethylamιnocarbonyl)phenoxy (pyrimidine; 2-methylsulfonyl-4-( 1 -carboxy-2-hydroxypropoxy) 5-nιtro-6-(5-ethoxycarbonyl- 3-methylphenoxy (pyrimidine; 2-methylsulfonyl-4-( 1 -carboxy-2-(amιnocarbonyl)ethoxy)-5-nιtro-6-(5-dιmethylamιno- 3-(ιmιdazolιn-2-yl)phenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-3-(amιnocarbonyl)propoxy)-5-nιtro- 6-(5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl(phenoxy)pyrιmιdιne, 2-methylsulf onyl-4-( 1 ,2-dιcarboxyethoxy)-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-methylsulf onyl-4-( 1 , 3-dιcarboxypropoxy)-5-nιtro-6-(5-(2-ethoxycarbonylethyl)- 3-(tetrahydropyrιmιdιn-2-yl)phenoxy)pyrιmιdιne; 2-methylsuifonyl-4-( 1 -carboxy-5-amιnopentoxy)-5-nιtro-6-(5-(dιmethylamιnocarbonyl) methyl 3-(ιmιdazol-2-yl)phenoxy)pyrιmιdιne; and 2-methylsulf onyl-4-( 1 -carboxy-4-guanιdιnobutoxy)-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne. G. In a similar manner, 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2 benzyloxy-5-cyanophenoxy)pyrιmιdιne, a compound of formula (U) , is oxidized to afford 2-methylsulf onyl-4-(ethoxycarbonyl(methoxy-5-nιtro-6-(2-benzyloxy-5-cyanophenoxy (pyrimidine, a compound of formula (V) . H . In a similar manner, the following compounds of formula (V) are prepared- 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6 (2-methoxy-5-cyanophenoxy (pyrimidine, 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6 (2-ethoxy-5-cyanophenoxy (pyrimidine; 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6 (3-methoxy-5-cyanophenoxy)pyrιmιdιne, 2-methylsulf onyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6 (3-ethoxy-5-cyanophenoxy)pyrιmιdιne; 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6- (2-phenoxy-5-cyanophenoxy)pyπmιdιne, 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6 (3-phenoxy-5-cyanophenoxy)pyπmιdιne, 2-methylsulf onyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6 (2-chloro-5-cyanophenoxy)pyrιmιdιne, 2-methylsulf onyl-4-(ethoxycarbonyl(methoxy-5-nιtro-6- (3-bromo-5-cyanophenoxy)pyrιmιdιne, 2-methylsulfonyl-4-(ethoxycarbonyl(methoxy-5-nιtro-6 (2-methyl-5-cyanophenoxy)pyrιmιdιne, 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6 (2-methyl-5-cyanophenoxy)pyrιmιdιne, 2-methylsulf onyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6 (3-methyl-4-cyanophenoxy (pyrimidine, 2-methylsulf onyl-4-{ethoxycarbonyl)methoxy-5-nιtro-6 (2-nιtro-5-cyanophenoxy (pyrimidine; 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6 (3-nιtro-4-cyanophenoxy)pyπmιdιne; 2-methylsulf onyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6 (2-carboxy-5-cyanophenoxy)pyrιmιdιne 2-methylsulfonyl-4-(ethoxycarbonyi)methoxy-5-nιtro-6 (3-carboxy-4-cyanophenoxy (pyrimidine, 2-methylsulf onyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6- (2-r-butoxycarbonyl- 5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-r-butoxycarbonyl- 4-cyanophenoxy) pyrimidine; 2-methylsulf onyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-amιnocarbonyl- 5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-amιnocarbonyl- 4-cyanophenoxy)pyrιmιdιne; 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-dιmethylamιno- 5-cyanophenoxy)pyπmιdιπe; 2-methylsulf oπyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(2-dιmethylamιno- 5-cyanophenoxy)pyrιmιdιne; 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy)pyrιmιdιne; 2-methylsulf oπyl-4-( 1 -carboxyethoxy)-5-nιtro-6-(3-bromo-5-cyanophenoxy (pyrimidine; 2-methylsulfonyl-4-( 1 -carboxy-2-methylpropoxy)-5-nιtro-6-(2-methyl-5-cyanophenoxy)pyrιmιdιne, 2-methylsulf onyl-4-( 1 -carboxy-3-methylbutoxy)-5-nιtro-6-(2-methyl- 5-cyanophenoxy (pyrimidine, 2-methylsulfonyl-4-( 1 -carboxy-2-methylbutoxy)-5-nιtro-6-(3-methyl-4-cyanophenoxy (pyrimidine, 2-methylsulfonyl-4-( 1 -carboxy-2-phenylethoxy)-5-nιtro-6-(2-nιtro-5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-( 1 -carboxy-2-(4-sulfonylphenyl)ethoxy)-5-nιtro-6-(3-nιtro- 4-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-( 1 -carboxy-3-(methylsulfonyl)propoxy(- 5-nιtro-6-( 2-carboxy- 5-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl-4-( 1 -carboxy-2-(ιmιdazol-4-yl)ethoxy)-5-nιtro-6-(3-carboxy- 4-cyanophenoxy)pyrιmιdιne; 2-methylsulf onyl -4-( 1 -carboxy-2-hydroxyethoxy)-5-nιtro-6-( 2-r-butoxycarbonyl- 5-cyanophenoxy (pyrimidine; 2-methylsulf onyl-4-(1 -carboxy-2-hydroxypropoxy)-5-nιtro-6-(3-r-butoxycarbonyl- 4-cyanophenoxy)pyπmιdιne; 2-methylsulf onyl-4-( 1 -carboxy-2-(amιnocarbonyl)ethoxy)-5-nιtro-6-(2-amιnocarbonyl- 5-cyanophenoxy)pyrιmιdιne; 2-methylsulfonyl-4-( 1 -carboxy-3-(amιnocarbonyl)propoxy)-5-nιtro-6-(3-amιnocarbonyl- 4-cyanophenoxγ)pyrιmιdιne; 2-methylsulf onyl-4-( 1 , 2-dιcarboxγethoxy)-5-nιtro-6-(2-dιmethylamιno- 5-cyanophenoxy)pyπmιdιne; 2-methγlsulfonyl-4-( 1 ,3-dιcarboxypropoxy)-5-nιtro-6-(3-dιmethγlammo- 4-cyanophenoxy)pyrιmιdιne, 2-methylsulf onyl-4-( 1 -carboxy-5-amιnopentoxy)-5-nιtro-6-(2-dιmethylamιno- 5-cyanophenoxy)pyrιmιdιne; and 2-methylsulfonyl-4-( 1 -carboxy-4-guanιdιnobutoxy)-5-nιtro-6-(3-dιmethylamιno- 4-cyanophenoxy)pyrιmιdιne. PREPARATION 5 Compounds of formula (H), formula (K) and formula (S) A. To 2-methylsulfonyl-4-(ethoxycarbonγlmethyl)amιno-5-nιtro-6-(3- (dιmethylamιnocarbonyl)phenoxypyrιmιdιne (3.5 g, 7.49 mmol), a compound of formula (F), in 80 mL acetonitrile at 0 °C was added cesium carbonate (3.1 7 g, 9.73 mmol), followed by the addition of 2-benzyloxy-5-cyanophenol ( 1 .6 g, 7.49 mmol) . The resulting reaction mixture was stirred for 1 5 minutes. The volatiles were evaporated and the residue chromatographed on silica (CH 2 CI 2 /ethγl acetate, 10: 1 , then 5 1 ) to afford 2.1 g (46 % yield) of 2-(2-benzyloxy-5- cyanophenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-(dιmethylamιnocarbonyl(- phenoxypyπmidine, a compound of formula (H). B. In a similar manner, the following compounds of formula (H) are prepared: 2-(2 benzyloxy-5-cyanophenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(3-(dιethylamιno- carbonyDphenoxyJpyπmidine; 2 (2-methoxy-5-cyanophenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-methyl-3-(dιmethyl- aminocarbonyl)phenoxy)pyrimidine; 2-(2-ethoxy-5-cyanophenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-trιfluoromethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-(2-phenoxy-5-cyanophenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-methoxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-(2-chloro-5-cyanophenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-carboxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyπmιdιne; 2-(2-methyl-5-cyanophenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-ethoxycarbonyl- 3-methylphenoxy)pyπmιdine; 2-(2-?-butyl-5-cyanophenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-( 5-dιmethylamιno- 3-(ιmιdazolιn-2-yl)phenoxy)pyπmιdιne; 2-(2-nιtro-5-cyanophenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro- 6-(5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy)pyrιmιdιne, 2-(2-carboxy-5-cyanophenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-(2-benzyloxycarbonyl-5-cyanophenoxy)-4-(ethoxycarbonylmethyl)amιno-5-nιtro- 6-(5-(2-ethoxycarbonylethyl)-3-(tetrahydropyrιmιdιn-2-yl)phenoxy)pyrιmιdιne; 2-(2-dιethylamιnocarbonyl-5-cyanophenoxy)-4-( 1 -carboxyethyl)amιno-5-nιtro- 6-( 3-(dιethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-( 2-amιno- 5-cyanophenoxy )-4-( 1 -carboxy-2-methylpropyl)amιno-5-nιtro-6-( 5-methyl- 3-(dιmethyl-amιnocarbonyl)phenoxy (pyrimidine; 2-(2-benzyloxy-5-cyanophenoxy)-4-( 1 -carboxy-3-methylbutyl)amιno-5-nιtro-6-( 5-tπfluoromethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-(2-methoxy-5-cyanophenoxy)-4-( 1 -carboxy-2-methylbutyl)amιno-5-nιtro-6-(5-methoxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyπmιdιne; 2-(2-ethoxy- 5-cyanophenoxy )-4-(1 -carboxy-2-phenylethyl)amιno-5-nιtro-6-(5-carboxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-(2-phenoxy-5-cyanophenoxy)-4-( 1 -carboxy-2-(4-sulfonylphenyl)ethyl)amιno-5-nιtro- 6-(5-ethoxycarbonyl-3-methylphenoxy)pyrιmιdιne; 2-(2-chloro-5-cyanophenoxy)-4-( 1 -carboxy-3-()propyl)amιno-5-nιtro-6-( 5-dιmethylamιπo- 3-(ιmιdazolιn-2-yl)phenoxy)pyrιmιdιne; 2-(2-methyl-5-cyanophenoxy)-4-( 1 -carboxy-2-sulfonylethyl)amιno-5-nιtro- 6-(5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy) pyrimidine; 2-<2-f-butyl- 5-cyanophenoxy)-4-( 1 -carboxy-2-(ιndolιn-3-yl)ethyl)amιno 5-nιtro- 6-( 5-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxy) pyrimidine; 2-(2-nιtro-5-cyanophenoxy)-4-( 1 -carboxy-2-(ιmιdazol-4-yl)ethyl)amιno-5-nιtro- 6-(5-(2-ethoxycarbonylethyl)-3-(tetrahydropyrιmιdιn-2-yl)phenoxy)pyrιmιdιne; 2-(2-carboxy-5-cyanophenoxy)-4-( 1 -carboxy- 2-hydroxyethyi)amιno-5-nιtro-6-(5-carboxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyπmιdιne; 2- (2-benzyloxycarbonyl- 5-cyanophenoxy )-4-( 1 -carboxy -2-hydroxypropyl la ino- 5-nιtro-6-(5-ethoxycarbonyl-3-methylphenoxy)pyrιmιdιne; 2-(2-dιethylammocarbonyl-5-cyanophenoxy)-4-( 1 -carboxy-2-(amιnocarbonyl)ethyl)amιno- 5-nιtro-6-(5-dιmethylamιno-3-(ιmιdazolιn-2-yl)phenoxy)pyrιmιdιne; 2-(2-amιno-5-cyanophenoxy)-4-( 1 -carboxy-3-(amιnocarbonyl)propyl)amιno-5-nιtro-6-(5- (dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy (pyrimidine; 2-(2-benzyloxy-5-cyanophenoxy)-4-( 1 ,2-dιcarboxyethyl)amιno-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyπmιdιne; 2-(2-benzyloxy-5-cyanophenoxy)-4-( 1 ,3-dιcarboxypropyl)amιno-5-nιtro- 6-( 5-(2-ethoxycarbonylethyl)-3-(tetrahydropyrιmιdιn-2-yl)phenoxy) pyrimidine; 2-(2-benzyloxy-5-cyanophenoxy)-4-( 1 -carboxy-5-amιnopentyl)amιno-5-nιtro- 6-( 5-(dιmethylamιnocarbonyl)methyl-(3-(ιmιdazol-2-yl)phenoxy)pyrιmιdιne; and 2-(2-benzyloxy-5-cyanophenoxy)-4-( 1 -carboxy-4-guanιdιnobutyl)amιno-5-nιtro- 6-(5-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne. C. In a similar manner, 2-methylthιo-4,6-dιchloro-5-nιtropyrιmιdιne, a compound of formula (A), was treated with 2-benzyloxy-5-cyanophenol to yield 2-methylthιo-4-chloro-5-nιtro- 6-(2-benzyloxy-5-cyanophenoxy)pyrιmιdιne, a compound of formula (K). D. In a similar manner, the following compounds of formula (K) are prepared . 2-methylthιo-4-chloro-5-nι ro-6-(2-methoxy-5-cyanophenoxy)pyπmιdιne; 2-methylthιo-4-ch!oro-5-nι ro-6-(2-ethoxy-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-chloro-5-nι ro-6-(3-methoxy-5-cyanophenoxy) pyrimidine; 2-methylthιo-4-chloro-5-nι ro-6-(3-ethoxy-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-chloro-5-nι ro-6-(2-phenoxy-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-chloro-5-nr ro-6-(3-phenoxy-5-cyanophenoxy) pyrimidine; 22--mmeetthhyylltthhιιoo--44--cchhlloorroo--55--nnιιt trro-6-(2-chloro-5-cyanophenoxy)pyπmιdιne; 2-methylthιo-4-chloro-5-nι ro-6-(3-bromo-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-chloro-5-nι ro-6-(2-methyl-5-cyanophenoxy)pyπmιdιne; 2-methylthιo-4-chloro-5-nι ro-6-(3-methyl-4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-chloro-5-nι ro-6-(2-nιtro-5-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-chloro-5-nι ro-6-(3-nιtro-4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-chloro-5-nι ro-6-(2-carboxy-5-cyanophenoxy (pyrimidine; 2-methylthιo-4-chloro-5-πι ro-6-(3-carboxy-4-cyanophenoxy (pyrimidine; 2-methylthιo-4-chloro-5-nι ro-6-(2-r-butoxycarbonyl-5-cyanophenoxy (pyrimidine; 2-methylthιo-4-chloro-5-nι ro-6-(3-r-butoxycarbonyl-4-cyanophenoxy)pyrιmιdιne; 22--mmeetthhyylltthhιιoo--44--cchhlloorroo--55--nnιιt trro-6-(2-amιnocarbonyl-5-cyanophenoxy (pyrimidine; 2-methylthιo-4-chloro-5-nι ro-6-(3-amιnocarbonyl-4-cyanophenoxy (pyrimidine; 2-methylthιo-4-chloro-5-nι ro-6-(2-dιmethylamιno-5-cyanophenoxy (pyrimidine; 2-methylthιo-4-chloro-5-nι ro-6-(3-dιmethylamιno-4-cyanophenoxy)pyrιmιdιne; 2-methylthιo-4-chloro-5-nι ro-6-(2-dιmethylamιno-5-cyanophenoxy)pyrιmιdιne; and 22--mmeetthhyylltthhιιoo--44--cchhlloorroo--55--nnιι ttrro-6-(3-dιmethylamιno-4-cyanophenoxy)pyrιmιdιne. E. In a similar manner, 2-methylsulfonyl-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(3- dιmethylamιnocarbonylphenoxγ)pyrιmιdine, a compound of formula (R), was treated with 2-benzyloxy-5-cyanophenol to yield 2-{2-benzyloxy-5-cyanophenoxy)-4- (ethoxycarbonyl)methoxy-5-nιtro-6-(3-dιmethylamιnocarbonylphenoxy)pyrιmιdιne, a compound of formula (S) . F. In a similar manner, the following compounds of formula (S) are made: 2-(2-benzyloxy-5-cyanophenoxy)-4-(ethoxycarboπyl)methoxy-5-nιtro-6-(3-(dιethylamιno- carbonyl)phenoxy)pyπmιdιne; 2-(2-methoxy-5-cyanophenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-methyl-3-(dιmethyl- aminocarbonyDphenoxylpyrimidine; 2-(2-ethoxy-5-cyaπophenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-tπfluoromethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-(2-phenoxy-5-cyanophenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-methoxy- 3-(dιmethylamιnocarbonyl)phenoxy(pyrιmιdιne; 2-(2-chloro-5-cyanophenoxy)-4-(ethoxycarbonyl(methoxy-5-nιtro-6-(5-carboxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-(2-methyl-5-cyanopheπoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-ethoxycarbonyl- 3-methylphenoxy)pyπmιdιne; 2-(2-r-butyl-5-cyanophenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-dιmethylamιno- 3-(ιmιdazolιn-2-yl)phenoxy)pyrιmιdιne; 2-(2-nιtro-5-cyanophenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro- 6-(5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy (pyrimidine; 2-(2-carboxy-5-cyanopheπoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro-6-(5-(dιmethylamιnoethyl 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-(2-benzyloxycarbonyl-5-cyanophenoxy)-4-(ethoxycarbonyl)methoxy-5-nιtro- 6 ( 5- (2-ethoxycarbonylethyl)-3-(tetrahydropyrιmιdιn-2-yl)phenoxy (pyrimidine; 2-(2-dιethylamιnocarbonyl-5-cyanophenoxy)-4-( 1 -carboxyethoxy)-5-nιtro- 6-(3-(dιethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-(2-amιno-5-cyanophenoxy(-4-( 1 -carboxy-2-methyipropoxy(-5-nιtro-6-(5-methyl-3-(dιmethyl- amιnocarbonyl)phenoxy)pyrιmιdιne; 2-(2-benzyloxy-5-cyanophenoxy)-4-( 1 -carboxy-3-methylbutoxy)-5-nιtro-6-( 5-trιfluoromethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-(2-methoxy-5-cyanophenoxy)-4-( 1 -carboxy-2-methylbutoxy)-5-nιtro-6-(5-methoxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-(2-ethoxy-5-cyanophenoxy)-4-( 1 -carboxy-2-phenylethoxy)-5-nιtro-6-( 5-carboxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyπmιdιne, 2-(2-phenoxy-5-cyanophenoxy)-4-( 1 -carboxy-2-(4-sulfonylphenyl)ethoxy)-5-nιtro- 6-(5-ethoxycarbonyl-3-methylphenoxy)pyrιmιdιne; 2-(2-chloro-5-cyanophenoxy)-4-( 1 -carboxy-3-(methylsulfonyl)propoxy)-5-nιtro-6- (5-dιmethylamιno-3-(ιmιdazolιn-2-yl)phenoxy (pyrimidine; 2-(2-methyl-5-cyanophenoxy)-4-( 1 -carboxy-2-sulfonylethoxy)-5-nιtro- 6-(5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy)pyrιmιdιne; 2-(2-r-butyl- 5-cyanophenoxy)-4-( 1 -carboxy-2-(ιndolιn-3-yl)ethoxy)-5-nιtro- 6-( 5-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxy (pyrimidine; 2-(2-nιtro-5-cyanophenoxy)-4-( 1 -carboxy-2-(ιmιdazol-4-yl)ethoxy)-5-nιtro 6-(5-( 2-ethoxycarbonylethyl)-3-(tetrahydropyrιmιdιn-2-yl)phenoxy)pyrιmιdιne; 2-(2-carboxy-5-cyanophenoxy)-4-( 1 -carboxy-2-hydroxyethoxy)-5-nιtro-6-(5-carboxy- 3-(dιmethylamιnocarbonyl)phenoxy)pyrιmιdιne; 2-(2-benzyloxycarbonyl-5-cyanophenoxy)-4-( 1 -carboxγ-2-hγdroxypropoxy(- 5-nιtro-6-(5-ethoxycarbonyl-3-methylphenoxy)pyrιmιdιne; 2 (2-dιethylamιnocarbonyl-5-cγanophenoxy)-4-( 1 -carboxy-2-(amιnocarbonyl)ethoxy(- 5-nιtro-6-(5-dιmethylamιno-3-(ιmιdazolιn-2-yl)phenoxy)pyrιmιdιne; 2-(2-amιno-5-cyanophenoxy(-4-( 1 -carboxy-3-(amιnocarbonyl)propoxy)-5-nιtro-6-(5- (dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy)pyrιmιdine; 2-(2-benzyloxy-5-cyanophenoxy)-4-( 1 ,2-dιcarboxyethoxy)-5-nιtro-6-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)pyπmιdιne; 2-(2-benzyloxy-5-cyanophenoxy)-4-( 1 ,3-dιcarboxypropoxy)-5-nιtro-6-(5-(2-ethoxycarbonylethyl)- 3-(tetrahydropyπmιdιn-2-yl)phenoxy)pyrιmιdιne; 2-(2-benzyloxy-5-cγanophenoxy)-4-( 1 -carboxy-5-amιnopentoxy)-5-nιtro- 6-(5-(dιmethylamιnocarbonyl)methyl-(3-(ιmιdazol-2-yl)phenoxy (pyrimidine; and 2-(2-benzyloxy-5-cyanophenoxy)-4-( 1 -carboxy-4-guanιdιnobutoxy)-5-nιtro- 6-(5-(dιmethylamιnoethyl-3-(dιmethγlamιnocarbonyl)phenoxy (pyrimidine PREPARATION 6 Compounds of formula (J), formula (0) , formula (T) and formula (X) A. 2-(2-Benzyloxy-5-cyanophenoxy)-4-(ethoxycarbonylmethyi)amιno-5-nιtro-6-(3- (dιmethylamιnocarbonyDphenoxy)pyrιmιdιne ( 1 .1 g, 1 .80 mmol), a compound of formula (H), and granular zinc (0.5 g) were mixed with tetrahydrofuran (50 mL) and 1 0% aqueous HCI ( 1 0 mL) The reaction mixture was heated for 30 minutes at 70°C. The volatiles were evaporated Saturated aqueous NaHC0 3 was added and the solution extracted with ethyl acetate (300 mL) . The organic layer was dried (Na 2 S0 4 ) and evaporated to afford 1 .35 g of 2 (2-benzyloxy-5-cyanoρhenoxy)-4-(3-(dιmethylamιnocarbonyl)phenoxy)- 1 ,7-dιhydro-6(5/V)- pteπdinone, a compound of formula (J). B. In a similar manner, the following compounds of formula (J) are prepared: 2-(2-benzyloxy-5-cyanophenoxy)-4-(3-(dιethylamιno-carbonyl)phenoxy(- 1 ,7-dιhydro-6(5/- )-pterιdιnone; 2-(2-methoxy-5-cyanophenoxy)-4-(5-methyl-3-<dιmethyl- amιnocarbonyl)phenoxy)- 1 ,7-dιhydro-6(5//)-pterιdιnone; 2-(2-ethoxy-5-cyanophenoxy)-4-(5-trιfluoromethyl- 3-(dιmethylamιnocarbonyl)phenoxy)-1 ,7-dιhydro-6(5 y)-pterιdιnone; 2-(2-phenoxy-5-cyanophenoxy)-4-(5-methoxy- 3-(dιmethylamιnocarbonyl)phenoxy)-1 , 7-dιhydro-6(5/-/)-pterιdιnone; 2-(2-chloro-5-cyanophenoxy)-4-(5-carboxy- 3-(dιmethylamιnocarbonyl)phenoxy)-1 ,7-dιhydro-6(5A )-pterιdιnone; 2-(2-methyt-5-cyanophenoxy)-4-(5-ethoxycarbonyl- 3-methylphenoxy)- 1 ,7-dιhydro-6(5/V)-pterιdιnone; 2-(2-r-butyl-5-cyanophenoxy)-4-(5-dιmethylamιno- 3-(ιmιdazolιn-2-yl(phenoxy)-1 ,7-dιhydro-6(5/ (-pteπdιnone; 2-(2-amιno-5-cyanophenoxy)-4-(5-(dιmethylamιnocarbonyl)methγl-3-(ιmιdazol-2-yl)phenoxy)- 1 , 7-dιhydro-6( 5/S ' )-pterιdιnone; 2-(2-carboxy-5-cyanophenoxy)-4-(5-(dιmethylamιnoethyl- 3-(dιmethylamιnocarbonyl)phenoxy)- 1 , 7-dιhydro-6(5/7)-pterιdιnone; 2-(2-benzyloxycarbonyl-5-cyanophenoxy)-4-(5-(2-ethoxycarbonylethyl)-3-(tetrahydropyrιmιdιn- 2-yl)phenoxy)- 1 ,7-dιhydro-6( 5/ L )-pterιdιnone, 2-(2-dιethylamιnocarbonyl-5-cyanophenoxy)-4-(3-(dιethylamιnocarbonyl)phenoxy)-7-methyl- 1 , 7-dιhydro-6(5 /)-pterιdιnone; 2-(2-amιno-5-cyanophenoxy)-4-(5-methyl-3-(dιmethyl-amιnocarbonyl )phenoxy)-7-( 1 -methylethyl)- 1 ,7-dιhydro-6(5/ )-pterιdιnone; 2-(2-benzyloxy-5-cyanophenoxy)-4-(5-trιfluoromethyl-3-(dιmethylamιnocarbonyl)phenoxy(- 7-(2-methylpropyl)-1 , 7-dιhydro-6(5 V)-pterιdιnone; 2-(2-methoxy-5-cyanophenoxy)-4-(5-methoxy-3-(dιmethyiamιnocarbonyl)phenoxy)- 7-( 1 -methylpropyl)- 1 ,7-dιhydro-6(5 V)-pterιdιnone; 2-(2-ethoxy-5-cyanophenoxy)-4-(5-carboxy-3-(dιmethylamιnocarbonyl)phenoxy)-7-benzyl- 1 , 7-dihydro-6(5A/)-pteridinone; 2-(2-phenoxy-5-cyanophenoxy)-4-(5-ethoxycarbonyl-3-methylphenoxy(- 7-(4-sulfonylphenyl)methyl-1 ,7-dιhydro-6(5 V)-pterιdιnone; 2-(2-chloro-5-cyanophenoxy)-4-(5-dιmethylamιno-3-(ιmιdazolιn-2-yl)phenoxy) 7-(2-methylsulfonyl)ethyl-1 ,7-dιhydro-6(5 -/)-pterιdιπone; 2-(2-methyl-5-cyanophenoxy)-4-(5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy(- 7-(sulfonylmethyl)-1 ,7-dιhydro-6(5 y)-pterιdιnone; 2-(2-r-butyl-5-cyanophenoxy)-4-(5-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxy(- 7-(ιndolιn-3-yl)methyl- 1 ,7-dιhydro-6(5/ )-pterιdιnone; 2-(2-amιno-5-cyanophenoxy)-4-(5-(2-ethoxycarbonylethyl)-3-(tetrahydropyrιmιdιn-2-yl)phenoxy(- 7-(ιmιdazol-4-yl)methyl- 1 ,7-dιhydro-6(5 y)-pterιdιnone; 2-(2-carboxy-5-cyanophenoxy)-4-(5-carboxy-3-(dιmethylamιnocarbonyl)phenoxy)- 7-(hydroxymethyl)-1 ,7-dιhydro-6(5 -/)-pterιdιnone; 2-(2-benzyloxycarbonyl-5-cyanophenoxy)-5-amιno-4-(5-ethoxycarbonyl-3-methylphenoxy)- 7 ( 1 -hydroxyethyl)- 1 ,7-dιhydro-6(5H)-pteπdιnone; 2-(2-dιethylamιnocarbonyl-5-cyanophenoxy)-5-amιno-4-(5-dιmethylamιno-3-(ιmιdazolιn- 2-yl)phenoxy)-7-(amιnocarbonylmethyl)-1 ,7-dιhydro-6(5 -r)-pterιdιnone; 2-(2-amιno-5-cyanophenoxy)-4-(5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy(- 7-(2-(amιnocarbonyl)ethyl)- 1 , 7-dιhydro-6(5A/)-pterιdιnone; 2-(2-beπzyloxy-5-cyanopheπoxy)-4-(5-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxy(- 7-(carboxymethγl)- 1 ,7-dιhydro-6(5 )-pterιdιnone; 2-(2-benzyloxy-5-cyanophenoxγ)-4-(5-(2-ethoxycarbonylethyl)-3-(tetrahydropyrιmιdιn- 2-yl)phenoxy)-7-(2-carboxyethyl)- 1 ,7-dιhydro-6(5 V)-pterιdιnone, 2-(2-benzyloxy-5-cyanophenoxy)-4-(5-(dιmethylamιnocarbonyl)methγl-(3-(ιmιdazol-2-yl)phenoxγ(- 7-(4-amιnobutyl(- 1 ,7-dιhydro-6(5/'-/)-pterιdιπone; and 2-(2-benzyloxy-5-cyanophenoxy)-4-(5-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxy(- 7-(3-guanιdιnopropyl)-1 ,7-dιhydro-6(5λ/)-pterιdιnone. C. In a similar manner, 2-(3-dιmethylamιnocarbonylphenoxy)-4- (ethoxycarbonylmethyl)amιno-5-nιtro-6-(2-benzyloxy-5-cyanophenoxy)pyrιmιdιne, a compound of formula (N), was reduced and cyc zed to afford 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2- benzyloxy-5-cyanophenoxy)-1 ,7-dιhydro-6(5/ )-pterιdιnone, a compound of formula (O) . D. In a similar manner, the following compounds of formula (0) are prepared * 2 (3-methylphenoxy)-4-(2-methoxy-5-cyanophenoxy)- 1 ,7-dιhydro-6(5A/)-pterιdιnone; 2-(3-chloro-5-methoxyphenoxy)-4-(2-ethoxy-5-cyanophenoxy)- 1 ,7-dιhydro-6(5/τ')-pterιdιnone, 2-(4-trιfluoromethylphenoxy)-4-(3-methoxy-5-cyanophenoxy)- 1 ,7-dιhydro-6(5 y)-pterιdιnone, 2-(3, 5-dιamιnophenoxy)-4-(3-ethoxy-5-cyanophenoxy)-1 2-(3-guanιdιno-5-methylphenoxy)-4-(2-phenoxy-5-cyanophenoxy)- 1 ,7-dιhydro-6(5/Y)-pterιdιnone, 2-(3-ureιdophenoxy)-4-(3-phenoxy- 5-cyanophenoxy)- 1 ,7-dιhydro-6(5 )-pterιdιnone; 2-(3-(2-chloroethyl)-5-methylphenoxy)-4-(2-chloro-5-cyanophenoxy)- 1 , 7-dιhydro-6(5/--/)-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-bromo-5-cyanophenoxy)-1 ,7-dιhydro- 6(5 )-pterιdιnone; 2-(4-ethoxycarbonylphenoxy)-4-(2-methyl-5-cyanophenoxy)- 1 2-(3-( 1 -methylιmιdazol-2-yl)phenoxy)-4-(2-methyl-5-cyanophenoxy)- 1 ,7-dιhydro- 6(5Ay)-pterιdιnone; 2-(3-dιmethylamιnophenoxy)-4-(3-methyl-4-cyanophenoxy)- 1 ,7-dιhydro-6(5 )-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy-4-(2-amιno-5-cyanophenoxy)- 1 ,7-dιhydro- 6{5W(-pteπdιnoπe; 2-(3-r-butoxycarbonylphenoxy)-4-(3-amιno-4-cyanophenoxy)-1 ,7-dιhydro-6(5/ )-pterιdιnone; 2-(3-( 1 -methylιmιdazolm-2-yl)phenoxy)-4-(2-carboxy-5-cγanophenoxy(- 1 ,7-dιhydro-6(5 - )-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(3-carboxy-4-cyanoρhenoxy(- 1 ,7-dιhydro-6(5 -/)-pterιdιnone; 2-(3-< 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(2-f-butoxycarbonyl-5-cyanophenoxy)- 1 ,7-dιhydro-6(5/-/)-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(3-f-butoxycarbonyl-4-cyanophenoxy(- 1 ,7-dιhydro-6(5λ )-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(2-amιnocarbonyl-5-cyanophenoxy(- 1 ,7-dιhydro-6(5/ )-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(3-amιnocarbonyl-4-cyanophenoxy)- 1 ,7-dιhydro-6(5/V)-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(2-dιmethylamιno-5-cyanophenoxy(- 1 , 7-dιhydro-6(5W)-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(3-dιmethylamιno-4-cyanophenoxy(- 1 ,7-dιhγdro-6(5 V)-pteπdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(2-dιmethγlamιno-5-cyanophenoxy(- 1 ,7-dιhydro-6(5/y)-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(3-dιmethylamιno-4-cyanophenoxγ)- 1 ,7-dιhydro-6(5/7)-pterιdιnone; 2-(3-( 1 -methγlιmιdazolιn-2-yl)phenoxy)-4-(2-methoxy-5-cyanophenoxy)- 1 ,7-dιhydro-6( 5 V)-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(2-ethoxy-5-cyanophenoxy)- 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(3-methoxy-5-cyanophenoxy)- 1 ,7-dιhydro-6(5r'- )-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(3-ethoxy-5-cyanophenoxy(- 1 ,7-dιhydro-6(5W)-ptendιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(2-phenoxγ- 5-cyanophenoxy )- 1 , 7-dιhydro-6(5W)-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-phenoxy-5-cyanophenoxy(- 1 ,7-dihydro-6(5 /)-pteπdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-chloro-5-cyanophenoxy)-1 ,7-dιhydro- 6(5A )-pteπdιnone; 2-(3-dιmethγlamιnocarbonylphenoxy)-4-(3-bromo-5-cyanophenoxy)-1 ,7-dιhγdro- 6(5/ )-pterιdιnone; 2-(3-dιmethγlamιnocarbonylphenoxy)-4-(2-methyl-5-cyanoρhenoxy)-1 ,7-dιhydro- 6(5W)-pteridinone; 2 (3-dιmethylamιnocarbonylphenoxy)-4-(2-methyl-5-cyanophenoxγ)- 1 ,7-dιhydro- 6(5/- )-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-methyl-4-cyanophenoxγ)- 1 ,7 dihydro- 6(5W)-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-amιno-5-cyanophenoxyi- 1 ,7-dιhydro- 6(5A/)-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-amιno-4-cyanophenoxy(-1 ,7-dιhydro- 2-(3-guanιdιnophenoxy)-4-(2-carboxy- 5-cyanophenoxy)- 1 , 7-dιhydro-6(5/y)-pterιdιnone, 2-(3-guanidinophenoxy)-4-(3-carboxy-4-cyanophenoxy)-1 ,7-dihydro-6(5/V)-pteridinone, 2-(3-guanιdιnophenoxy)-4-(2-! * -butoxycarbonyl-5-cyanophenoxy)-1 ,7-dιhydro-6(5/-/)-pterιdιnone, 2-(3-guanιdιnophenoxy)-4-(3-f-butoxycarbonyl-4-cyanophenoxy)-1 ,7-dιhydro-6(5/y)-pteπdιnone; 2-(3-guanιdιnophenoxy)-4-(2-amιnocarbonyl-5-cyanophenoxy)-1 ,7-dιhydro-6(5 )-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(3-amιnocarbonyl-4-cyanophenoxy)- 1 ,7-dιhydro-6(5A )-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(3-dιmethylamιno-4-cyanophenoxy)- 1 ,7-dιhydro-6(5 V)-pterιdιnone, 2-(3-guanιdιnophenoxy)-4-(2-dιmethylamιno-5-cyanophenoxy)-7-methyl- 1 ,7-dιhydro-6(5 V)-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(3-dιmethylamιno-4-cyanophenoxy)-7-( 1 -methylethyl(- 1 , 7-dιhydro-6(5 V)-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-bromo-δ-cyanophenoxy)-7-(2-methylpropyl(- 1 ,7-dιhydro-6(6/Y)-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-methyl-δ-cyanophenoxy)-7-( 1 -methylpropyl)- , 7-dιhydro-6(5A )-pterιdιnone, 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-methyl-5-cyanophenoxy)-7-benzyl- 1 , 7-dihydro-6(5/T")-pteridinone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-methyl-4-cyanophenoxy)-7-(4-sulfonylphenyl)methyl- 1 , 7-dιhydro-6(5 -/)-pterιdιnone; 2-( 3-dιmethylamιnocarbonylphenoxy)-4-(2-amιno-δ-cyanophenoxy)-7-( 2-methylsulf onyllethyl- 1 , 7-dιhydro-6(5A )-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-amιno-4-cyanopheπoxy)-7-(sulfonylmethyl(- 1 , 7-dιhydro-6(5 V)-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(2-carboxy-5-cyanophenoxy)-7-(ιπdolιn-3-yl)methyl- 1 ,7-dιhydro-6(5A )-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(3-carboxy-4-cyanophenoxy)-7-(ιmιdazol-4-yl)methyl- 1 ,7-dιhydro-6(5/V)-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(2-f-butoxycarbonyl-5-cyanophenoxy)-7-(hydroxymethyl(- 1 ,7-dιhydro-6(5M-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(3-f-butoxycarbonyl-4-cyanophenoxy)-7-( 1 -hydroxyethyl(- 1 ,7-dιhydro-6(5/τ')-pterιdιnone; 2-(3-guanιdιnophenoxy(-4-(2-amιnocarbonyl-5-cyanophenoxy)-7-(amιnocarbonylmethyl(- 1 , 7-dιhydro-6(5/V)-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(3-amιnocarbonyl-4-cyanophenoxy)-7-(2-(amιnocarbonyl)ethyl(- 1 ,7-dιhydro-6(5A/)-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(2-dιmethylamιno-5-cyanophenoxy)-7-(carboxymethyl)- 1 , 7-dιhydro-6( 5 V)-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(3-dιmethy!amιπo-4-cyanophenoxy)-7-(2-carboxyethyl)- 1 ,7-dιhydro-6(5/ ' τ ' )-pterιdιnone; 2-(3-guanιdιnophenoxy(-4-(2-dιmethylamιno-5-cyanophenoxy)-7-(4-amιnobutyD- 1 ,7-dιhydro-6(5/ )-pteπdιnone; and 2-(3-guanιdιnophenoxy)-4-(3-dιmethylamιno-4-cyanophenoxy)-7-(3-guanιdιnopropyl(- 1 ,7-dιhydro-6(5/y)-pteπdιnone. E. In a similar manner, 2-(2-benzyloxy-5-cyanophenoxy)-4- (ethoxycarbonyl)methoxy-δ-nιtro-6-(3-dιmethylamιnocarbonylphenoxy)pyrιmιdιne, a compound of formula (S) , was reduced and cyclized to afford 2-(2-benzyloxy-5-cyanophenoxy)-4-(3- (dιmethylamιnocarbonyl)phenoxy)-5/y-pyrιmιdo[4, 5-M 1 ,4]oxazιn-6(7/-/)-one, a compound of formula (T) F In a similar manner, the following compounds of formula (T) are prepared 2-(2-benzyloxy-δ-cyanophenoxy)-4-(3-(dιethylamιno- carbonyl)phenoxy)-5 /-pyrιmιdo[4, 5-6][ 1 ,4]oxazιn-6(7W)-one; 2-( 2-methoxy-5-cyanophenoxy)-4-(δ-methyl-3-(dιmethyl- amιnocarbonyl)phenoxy)-5 /-pyrιmιdo[4, 5-Z?][ 1 ,4]oxazιn-6(7 V)-one; 2-(2-ethoxy-5-cyanophenoxy)-4-(5-trιfluoromethyl- 3-(dιmethylamιnocarbonyl)phenoxy)-5/ -pyrιmιdo[4, 6-ό]t1 ,4]oxazιn-6(7/V)-one; 2-(2-phenoxy-δ-cyanophenoxy)-4-(5-methoxy-3-(dιmethylamιnocarbonyl)phenoxy(- 5 -pyrιmιdo[4, 5-ώ][1 ,4)oxazιn-6(7W)-one; 2-(2-chloro-5-cyanophenoxy)-4-(5-carboxy-3-(dιmethylamιnocarbonyl)phenoxy(- δ/ -pyrιmιdo(4, δ-ώ][ 1 ,4]oxazιn-6(7 )-one, 2-(2-methyl-5-cyanophenoxy)-4-(5-ethoxycarbonyi-3-methylphenoxy(- 5W-pyrιmιdo[4, 5-ό][ 1 ,4]oxazιn-6(7tf)-one; 2-(2-r-butyl-5-cyanophenoxy)-4-(5-dιmethylamιno-3-(ιmιdazolιn-2-yl)phenoxy(- 5 -pyrιmιdo[4,5-6][1 ,4loxazιn-6(7A )-one; 2-(2-amιno-5-cyanophenoxy)-4-(5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy)- δ -pyrιmιdo[4,δ- ?][ 1 ,4loxazιn-6(7W)-one; 2-(2-carboxy-5-cyanophenoxy)-4-(5-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxy(- 5 -pyrιmιdo[4,5-ώ]l 1 ,4]oxazιn-6(7W)-one; 2-(2-benzyloxycarbonyl-5-cyanophenoxy)-4-( 5-( 2-ethoxγcarbonylethyl)-3-(tetrahydropyrιmιdιn- 2-yl)phenoxy)-5A/-pyrιmιdo[4,5-σ][ 1 ,4]oxazιn-6(7 V)-one, 2-(2-dιethylamιnocarbonyl-5-cγanophenoxy)-4-(3-(dιethylamιnocarbonyl)phenoxy)- 5 V-pyrιmιdo[4, δ-o][1 ,4]oxazιn-6(7 )-one, 2-( 2-amιno-5-cyanophenoxy)-4-(5-methyl-3-(dιmethyl-amιnocarbonyl)phenoxy)- 7-methyl-5 τ , -pyrιmιdol4, δ-o][ 1 ,4]oxazιn-6(7 V)-one; 2-(2-benzyioxy-5-cyanophenoxy)-4-(5-trιfluoromethyl-3-(dιmethylamιnocarbonyl)phenoxy) 7-( 1 -methylethyl)-5/y-pyrιmιdo[4,5-6][ 1 ,4]oxazιn-6(7 τ')-one; 2 (2-methoxy-5-cyanophenoxy)-4-(5-methoxy-3-(dιmethylamιnocarbonyl)phenoxy(- 7-(2-methylpropyl)-5/Y-pyrιmιdo[4,5-ώl[ 1 ,4]oxazιn-6(7 -/)-one; 2-(2-ethoxy-5-cyanophenoxy)-4-(5-carboxy-3-(dιmethylamιnocarbonyl)phenoxy(- 7-( 1 -methylpropyl(-5/ -pyrιmιdo[4,5-Dlt1 ,4]oxazιn-6(7W)-one; 2-(2-phenoxy-5-cyanophenoxy)-4-(5-ethoxycarbonyl-3-methylphenoxy)-7-benzyl- 5/ -pyrιmιdo[4, 5-o][ 1 ,4]oxazιn-6(7W)-oπe; 2-(2-chloro-5-cyanophenoxy)-4-(5-dιmethylamιno-3-(ιmιdazolιn-2-yl)phenoxy(- 7-(4-sulfonylphenyl)methyl-5W-pyrimido[4, 5--j][ 1 ,4]oxazin-6(7/ )-one, 2-(2-methyl-5-cyanophenoxy)-4-(5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy) 7-(sulfonylmethyl)-5/y-pyπmιdo[4, 5-6][ 1 ,4]oxazιn-6(7 V)-one; 2-(2-r-butyl-5-cyanophenoxy)-4-(5-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxy(- 7-(ιndoiιn-3-yl)methyl-5/ -pyrιmιdo[4, 5-ώ][ 1 ,4]oxazιn-6(7/y)-one; 2-(2-amιno-5-cyanophenoxy)-4-(5-(2-ethoxycarbonylethyl)-3-(tetrahydropyrιmιdιn-2-yl)phenoxy) 7-(ιmιdazol-4-yl)methyl-5/¥-pyrιmιdo[4, 5-ύ][ 1 ,4]oxazιn-6(7 V)-one; 2-(2-carboxy-5-cyanophenoxy)-4-(5-carboxy-3-(dιmethylamιnocarbonyl)phenoxy)- 7-(hydroxymethyl)-5/ -pyrιmιdo[4,5-D][1 ,4]oxazιn-6(7 V)-one; 2-(2-benzyloxycarbonyl-5-cyanophenoxy)-4-(5-ethoxycarbonyl-3-methylphenoxy(- 7-( 1 -hydroxyethyl)-5/τ ' -pyrιmιdo[4,5-ώ][1 ,4]oxazιn-6(7/ )-one; 2-(2-dιethylamιnocarbonyl-5-cyanophenoxy)-4-(5-dιmethylamιno-3-(ιmιdazolιn-2-yl)phenoxy(- 7-(amιnocarbonylmethyl)-5W-pyrιmιdo[4,5-ώ][ 1 ,4]oxazιn-6(7/ |-one; 2-(2-amιno-5-cyanophenoxy)-4-(5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy) 7-(2-(amιnocarbonyl)ethyl)-5 V-pyrιmιdo[4, 5-6][1 ,4]oxazιn-6(7f )-one; 2-(2-benzyloxy-5-cyanophenoxy)-4-(5-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxy)- 7-(carboxymethyl)-5/ -pyπmιdo(4,5-6][ 1 ,4]oxazιn-6(7 /)-one; 2-(2-benzyloxy-5-cyanophenoxy)-4-(5-(2-ethoxycarbonylethyl)-3-(tetrahydropyrιmιdιn- 2-yl)phenoxγ)-7-(2-carboxyethyl)-5W-pyrιmιdo[4,5-6][ 1 ,4]oxazιn-6(7/ )-one; 2-(2-benzyloxy-5-cyanophenoxy)-4-(5-(dιmethylamιnocarbonyl)methyl-(3-(ιmιdazol-2-yl)phenoxγ)- 7-(4-ammobutyl)-5 /-pyrιmιdo[4,5-Λ]t1 ,4]oxazιn-6(7W)-one; and 2-(2-benzyloxy-5-cyanophenoxy)-4-(5-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxy(- 7-(3-guanιdιnopropyl)-5 -pyrιmιdo[4,5-ώ][ 1 ,4]oxazιn-6(7 )-one. G. In a similar manner, 2-(3-dιmethylamιnocarbonylphenoxy)-4-(ethoxycarbonyl)- methoxy-5-nιtro-6-(2-benzyloxy-5-cyano-phenoxy)pyrιmιdιne, a compound of formula (W) , is reduced and cyclized to afford 2-{3-dιmethylamιnocarbonylphenoxy)-4-(2-benzyloxy- 5-cyanophenoxy)-5 -pyrιmιdo[4,5-ώ][1 ,4]oxazιn-6(7 V)-one, a compound of formula (X) H In a similar manner, the following compounds of formula (X) are prepared 2-(3-methylphenoxy)-4-(2-methoxy-δ-cyanophenoxy)-5 -pyrιmιdo[4,5-ώ][1 ,4]oxazιn-6(7/y)-one, 2-(3-chloro-5-methoxyphenoxy)-4-(2-ethoxy-δ-cyanophenoxy)-δ/-pyrιmιdo[4,5-o][1 ,4]oxazιn- 6(7W)-one; 2-(4-trιfluoromethylphenoxy)-4-(3-methoxy-5-cyanophenoxy)-5 /-pyrιmιdo(4,5-6][1,4]oxazιn- 6(7W)-one; 2-(3,5-dιamιnophenoxy)-4-(3-ethoxy-5-cyanophenoxy)-5V-pyrιmιdo[4,5-ώ][1 ,4loxazιn-6(7 )-one; 2-(3-guanιdιno-5-methylphenoxy)-4-(2-phenoxy-δ-cyanophenoxy)-5/τ'-pyrιmιdo[4,5-6][1,4loxazιn- 6(7W)-one; 2-(3-ureidophenoxy)-4-(3-phenoxy-5-cyanophenoxy)-5 y-pyrimido[4,5-o][1 ,4]oxazιn-6(7A)-one; 2-(3-(2-chloroethyl)-5-methylphenoxy)-4-(2-chloro-5-cyanophenoxy(- 5 y-pyrιmιdo[4,5-ό][1 ,4]oxazιn-6(7/Y)-one; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-bromo-5-cyanophenoxy(- 5W-pyrιmιdo[4,5-ό][1,4]oxazιn-6(7 )-one, 2-(4-ethoxycar bonylphenoxy (-4- (2-methy I- 5-cyanophenoxy )- 5/-pyrιmιdo[4,5-o][1,4]oxazιn-6(7/V)-one; 2-(3-(l-methylιmιdazol-2-yl)phenoxy)-4-(2-methyl-5-cyanophenoxy(- 5/V-pyrιmιdo[4,5-ύ][1 ,4]oxazιn-6(7V)-one; 2-(3-dιmethylamιnophenoxy)-4-(3-methyl-4-cyanophenoxy(- 5W-pyrιmιdo[4,5-ό][1,4loxazιn-6(7/y(-one; 2-(3-( 1 -methyiιmιdazolιn-2-yl)phenoxy-4-(2-amιno-5-cyanophenoxy(- 5/-pyrιmιdo[4,5-o][1,4]oxazιn-6(7V)-one; 2-(3-f-butoxycarbonylphenoxy)-4-(3-amιno-4-cyanophenoxy(- 5A-pyrιmιdo[4,δ-6][1 ,4]oxazιn-6(7W)-one; 2-(3-(1-methylιmιdazolιn-2-yl)phenoxy)-4-(2-carboxy-5-cyanophenoxy)- 5 y-pyrιmιdo(4,5-d][1 ,4]oxazιn-6(7W)-one; 2-(3-(1-methylιmιdazolιn-2-yl)phenoxy)-4-(3-carboxy-4-cyanophenoxy(- 5f-pyπmιdo[4,5-ό][1 ,4]oxazιn-6(7W)-one; 2-(3-(1-methylιmιdazolιn-2-yl)phenoxy)-4-(2-f-butoxycarbonyl-5-cyanophenoxy(- 5/-pyrιmιdo[4,5-6][1,4]oxazιn-6(7rV)-one; 2-(3-(1-methylιmιdazolιn-2-yl)phenoxy)-4-(3-f-butoxycarbonyl-4-cyanophenoxy(- 5W-pyrιmιdo[4,5-o][1 ,4]oxazιn-6(7/V)-one; 2-(3-(1-methylιmιdazolιn-2-yl)phenoxy)-4-(2-amιnocarbonyl-5-cyanophenoxy(- 5--pyrιmιdo[4,5-D][1,4]oxazιn-6(7/y>-one; 2-(3-(1-methylιmιdazolιn-2-yl)phenoxy)-4-(3-amιnocarbonyl-4-cyanophenoxy)- 5 -pyrιmιdo[4,5-ώ][1 ,41oxazιn-6(7/V)-one; 2-(3-(1-methylιmιdazolιn-2-yl)phenoxy)-4-(2-dιmethylamιno-5-cyanophenoxy>- 5H-pyrιmιdo[4,5-ώ][1,4]oxazιn-6(7A)-one; 2-(3-(1 -methylιmιdazolιn-2-yl)phenoxy)-4-(3-dιmethylamιno-4-cyanophenoxy)- δf-pyrιmιdo(4,δ-ώ][1 ,4]oxazιn-6(7//)-one, 2-(3-(1-methylιmιdazolιn-2-yl)phenoxy)-4-(2-dιmethylamιno-5-cyanophenoxy(- 7-methyl-5/V-pyrιmιdo[4,5-ώ][1,4]oxazm-6(7W)-one; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(3-dιmethylamιno-4-cyanophenoxy(- 7-(1-methylethyl)-5/-pyrιmιdo[4,5--?][1,4]oxazιn-6(7 )-one; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-bromo-5-cyanophenoxy)-7-(2-methylpropyl(- 57-pyπmιdo[4,5-Λ][1,4]oxazιn-6(7/(-one; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-methyl-5-cyanophenoxy)-7-(1-methylpropyl(- 5Y-pyrιmιdo[4,5-ώ][1,4]oxazιn-6(7W)-one; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-methyl-5-cyanopheπoxy)-7-benzyl- 5f-pyrιmιdo[4,5-ό][1,4]oxazιn-6(7-)-one; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-methyl-4-cyanophenoxy)-7-(4-sulfonylphenyl)methyl- 5 -pynmido[4,5-6][1,4]oxazin-6(7/ )-one; 2-(3-dιmethylamιnocarbonylphenoxy(-4-(2-amιno-5-cyanophenoxy)-7-(2-methylsulfonyl)ethyl- 5 -pyrιmιdo[4,5-d][1,4]oxazιn-6(7V(-one; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-amιno-4-cyanophenoxy)-7-(sulfonylmethyl(- 5 V-pyrιmιdo[4,5-o][1,4]oxazιn-6(7/)-one; 2-(3-guanιdιnophenoxy)-4-(2-carboxy-δ-cyanophenoxy)-7-(ιndolιn-3-yl)methyl- δ L -pyπmιdo[4,5-6][1 ,41oxazιn-6(7W)-one; 2-(3-guanιdιnophenoxy)-4-(3-carboxy-4-cyanophenoxy)-7-(ιmιdazol-4-yl)methyl- 5/-pyrιmιdo[4,5-ό][1 ,4]oxazιn-6(7/)-one; 2-(3-guanιdιnophenoxy)-4-(2-f-butoxycarbonyl-5-cyanophenoxy)-7-(hydroxymethyl(- 5W-pyrιmιdo[4,5-6][1 ,4]oxazιn 2 (3-guanιdιnophenoxy)-4-(3-r-butoxycarbonyl-4-cyanophenoxy)-7 (1 -hydroxyethyl)- 5/ L /-pyrιmιdo[4,5-6][1,4]oxazιn-6(7y)-one; 2-(3-guanιdιnophenoxy)-4-(2-amιnocarbonyl-5-cyanophenoxy)-7-(amιnocarbonylmethyl)- 5#-pyrιmιdo[4,5-ø][1,4]oxazιn-6(7#)-one; 2-(3-guanιdιnophenoxy)-4-(3-amιnocarbonyl-4-cyanophenoxy)-7-(2-(amιnocarbonyl)ethyl(- 5 -pyrιmιdo[4,5-6][1 ,4]oxazιn-6(7W)-one; 2-(3-guanιdιnophenoxy)-4-(2-dιmethylamιno-5-cyanophenoxy)-7-(carboxymethyD- 5/ t /-pyπmιdo[4,5-ό][1 ,4]oxazιn-6(7r--/)-one; 2-(3-guanιdιnophenoxγ)-4-(3-dιmethylamιno-4-cyanophenoxy)-7-(2-carboxyethyl(- 54'-pyrιmιdo[4,5-ώ][1 ,4)oxazιn-6(7V)-one; 2-(3-guanιdιnophenoxy)-4-(2-dιmethylamιno-5-cyanophenoxy)-7-(4-amιnobutyl(- δV-pyrιmιdo[4,5-6][1 ,4]oxazιn-6(7y)-one; and 2-(3-guanιdιnophenoxy)-4-(3-dιmethylammo-4-cyanophenoxy)-7-(3-guanιdιnopropyl(- 5W-pyrιmιdo[4, 5-6111 ,4]oxazιn-6(7/ ( τ')-one. EXAMPLE 1 Compounds of formula (la) , formula (lla), formula (lb) and formula (lib) A. 2-(2-Benzyloxy-5-cyanophenoxy)-4-(3-(dιmethylamιnocarbonyl)phenoxy)-1 ,7- dihγdro-6(5AY)-pterιdιnone ( 1 .35 g, 2.52 mmol), a compound of formula (J), was dissolved in ethanol (60 mL) in a pressure vessel at 0°C and saturated with HCI gas. The reaction was sealed and allowed to warm to ambient temperature over 1 6 hours. The reaction mixture was then concentrated to about 20 mL and ether added to precipitate the ethyl imidate. The imidate was dissolved in ethanol (30 mL) , cooled to 0°C, and ammonia gas bubbled through the solution for 10 minutes. The reaction was sealed and heated at 60°C for 2 hours. The reaction was allowed to cool, the tube opened with caution and the volatiles evaporated to afford 1 .0 g of a brown residue. The residue (300 mg) was hydrogenated in ethanol over 10% Pd/C followed by addition of 6N HCI (8.0 mL) and heating to 100 °C. The reaction was filtered and the filtrate evaporated to afford 1 20 mg of the crude product. Purification by preparative HPLC afforded 60 mg of 2-(2-hydroxy-δ-amιdιnophenoxy)-4-(3-(dιmethylamιnocarbonyl)phenoxy)- 1 ,7- dιhydro-6(5 )-pterιdιnone, a compound of formula (la), NMR (DMS0-d 6 ) 1 0.30 (brs, 1 ) , 9.00 <brs,2), 8.80 (brs,2), 8.00 (br, 1 ), 7.60 (m,2), 7.60 (dd, 1 ) , 7.20-730 (m,4) , 7.00 (d, 1 ), 4.00 (s,2) , 2.90 (s,3) , 3.00 (s,3) . B. In a similar manner, the following compounds of formula (la) are prepared: 2-(2-hydroxy-5-amιdinophenoxy)-4-(3-(dιethylamιno- carbonyl)phenoxy)- 1 ,7-dihydro-6(5/V)-pterιdιnone; 2-(2-methoxy-5-amιdinophenoxy)-4-(5-methyl-3-(dιmethyl- amιnocarbonyl)phenoxy)- 1 ,7-dιhydro-6(5/-/)-pteπdιnone; 2-(2-ethoxy-5-amιdmophenoxy)-4-(5-trιfluoromethyl- 3-(dimethylamιnocarbonyl)phenoxy)-1 ,7-dihydro-6(5/ )-pterιdιnone; 2-(2-phenoxy-5-amidinophenoxy)-4-(5-methoxy- 3-(dimethylamιnocarbonyl)phenoxy(-1 ,7-dihydro-6(5/ )-pteridιnone; 2-(2-chloro-5-amιdinophenoxy)-4-(5-carboxy- 3-(dιmethylaminocarbonyl)phenoxy)-1 ,7-dihydro-6(5H)-pteridinone; 2-(2-methyl-5-amιdιnophenoxy)-4-(5-ethoxycarbonyl- 3-methylphenoxy)-1 ,7-dihydro-6(5 y)-pterιdinone; 2-(2-f-butyl-5-amidinophenoxy)-4-(5-dimethylamιno- 3-(imιdazolιn-2-yl)phenoxy)-1 2-(2-amιno-5-amιdιnophenoxy)-4-(5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy)- 1 ,7-dιhydro-6(5/-/)-pteπdιnone; 2-<2-carboxy-5-amιdιnophenoxy)-4-(6-(dιmethylamιnoethyl- 3-(dιmethylamιnocarboπyl)phenoxy)- 1 ,7-dιhydro-6(5/τ')-pterιdιnone, 2 (2-benzyloxycarbonyl-5-amιdιnophenoxy)-4-(5-(2-ethoxycarbonylethyl)-3-(tetrahydropyrιmιdιn- 2-yl)phenoxy)- 1 , 7-dιhydro-6(5/- )-pteπdιnone; 2-(2-dιethylamιnocarbonyl-δ-amιdιnophenoxy)-4-(3-(dιethylamιnocarbonyl)ρhenoxy)-7-methyl- 1 ,7-dιhydro-6(5H(-pterιdιnone; 2-(2-amιno-5-amιdιnophenoxy)-4-(5-methyl-3-(dιmethyl-amιnocarbonyl)phenoxy(- 7-( 1 -methylethyl)- 1 ,7-dιhydro-6(5 y)-pterιdιnone; 2 (2 hydroxy-5-amιdιnophenoxy)-4-(5-trιfluoromethyl-3-(dιmethyiamιnocarbonyl)phenoxy(- 7-(2-methylpropyl)- 1 ,7-dιhydro-6(5r*V)-pterιdιnone; 2-(2-methoxy-5-amιdιnophenoxy)-4-(5-methoxy-3-(dιmethylamιnocarbonyl)phenoxy(- 7-( 1 -methylpropyl)-1 ,7-dιhydro-6(5 )-pterιdιnone; 2-(2-ethoxy-5-amιdιnophenoxy)-4-(5-carboxy-3-(dιmethylamιnocarbonyl)phenoxy)-7-benzyl 1 ,7-dιhydro-6(5 y)-ptendιnone, 2-(2-phenoxy-δ-amιdιnophenoxy)-4-(5-ethoxycarbonyl-3-methylphenoxy(- 7-(4-sulfonylphenyl)methyl- 1 ,7-dιhydro-6(5/- )-pterιdιnone; 2-(2-chloro-5-amιdιnophenoxy)-4-(5-dιmethylamιno-3-(ιmιdazolιn-2-yl)phenoxy(- 7-(2-methylsulfonyl)ethyl-1 ,7-dιhydro-6(5/ )-pterιdιnone; 2-(2-methyl-5-amιdιnophenoxy)-4-(5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy(- 7-(sulfonylmethyl)-1 , 7-dιhydro-6(5A )-pterιdιnone; 2-(2-r-butyl-5-amιdιnophenoxy(-4-(5-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxy(- 7-(ιndolιn-3-yl)methyl- 1 ,7-dιhydro-6(δ/ t y)-pterιdιnone; 2-(2-amιno-δ-amιdιnophenoxy)-4-(δ-(2-ethoxycarbonylethyl)-3-(tetrahydropyrιmιdιn- 2-yl)phenoxy)-7-(ιmιdazol-4-yl)methyl-1 ,7-dιhydro-6(δA/)-pteπdιnone; 2-(2-carboxy-5-amιdιnophenoxy)-4-(5-carboxy-3-(dιmethylamιnocarbonyl)phenoxy(- 7-(hydroxymethyl)-1 ,7-dιhydro-6(5/V)-pterιdιnone; 2-(2-benzyloxycarbonyl-5-amιdιnophenoxy)-5-amιno-4-(5-ethoxycarbonyl-3-methylphenoxy(- 7-( 1 -hydroxyethyl)- 1 ,7-dιhydro-6(5A )-pterιdιnone; 2-(2-dιethylamιnocarbonyl-5-amιdιnophenoxy)-5-amιno-4-(5-dιmethylamιno- 3-(ιmιdazolιn-2-yl)pheπoxy)-7-(amιnocarbonylmethyi)- 1 ,7-dιhydro-6(5H)-pterιdιnone, 2-(2-amιno-5-amιdιnophenoxy)-4-(5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy)- 7-(2-(amιnocarbonyl)ethyl)- 1 ,7-dιhydro-6(5 - )-pterιdιnone; 2-(2-hydroxy-δ-amιdιnophenoxy)-4-(δ-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxy) 7-(carboxymethyl)- 1 ,7-dιhydro-6(5 V)-pterιdιnone; 2-(2-hydroxy-5-amιdιnophenoxy)-4-(5-(2-ethoxycarbonylethyl)-3-(tetrahydropyrιmιαιn- 2-yl)phenoxy)-7-(2-carboxyethyl)-1 ,7-dιhydro-6(5 )-pteπdιnone; 2-(2-hydroxy-5-amιdιπophenoxy)-4-(5-(dιmethylamιnocarbonyl)me hyl-(3-(ιmιdazol- 2 yl)phenoxy)-7-(4-amιnobutyl)- 1 ,7-dιhydro-6(5/y)-pterιdιnone, and 2-( 2-hydroxy- 5-amιdιnophenoxy)-4-(5-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxy)- 7-(3-guanιdιnopropyl)- 1 , 7-dιhydro-6(5 )-pterιdιnone C In a similar manner, 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-benzyloxy-5- amidinophenoxyH ,7-dιhydro-6(5W)-pteπdιnone, a compound of formula (0) , was treated to afford 0.1 0 g of 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-hydroxy-5-amιdιnophenoxy)-1 ,7- dιhydro-6(5A/)-pterιdιnone, a compound of formula (lla) , NMR (DMS0-d 6 ) 9 10 (brs,2), 8.80 (brs,2), 7.70 (m,2), 7.50 (dd, 1 ) , 7.20-7.40 (m,4), 7.10 (d, 1 ) , 4.90 (s,2), 3 00 (s,3), 2.90 (s, 3), 2.70 (s,3) . D. In a similar manner, the following compounds of formula (lla) are prepared: 2-(3-methylphenoxy)-4-(2-methoxy-5-amιdιnophenoxy)-1 ,7-dιhydro-6(5A )-pterιdιnone, 2-(3-chloro-5-methoxyphenoxy)-4-(2-ethoxy-5-amιdιnophenoxy)- 1 , 7-dιhydro-6(5/-')-pterιdιnone, 2-(4-trιfluoromethylphenoxy)-4-(3-methoxy-5-amιdιnophenoxy)-1 ,7-dιhydro-6(5 V)-pterιdιnone, 2-(3 , 5-dιamιnophenoxy)-4-(3-ethoxy-5-amιdιnophenoxy) 1 , 7-dιhydro-6(5/V)-pterιdιnone, 2-(3-guanιdιno-5-methylphenoxy)-4-(2-phenoxy-5-amιdιnophenoxy) 1 , 7 dihydro- 2-(3-ureιdophenoxy)-4-(3-phenoxy-5-amιdιnophenoxy)- 1 ,7-dιhydro-6( 5W)-pterιdιnone; 2-(3-(2-chloroethyl)-5-methylphenoxy)-4-(2-chloro-5-amιdιnophenoxy)- 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-bromo-5-amιdιnophenoxy(- 0 1 ,7-dιhydro-6(6#)-pteπdιnone; 2-(4-ethoxycarbonylphenoxy)-4-(2-methyl-5-amιdιnophenoxy)-1 ,7-dιhydro-6(5/ )-pteπdιnone, 2-(3-( 1 -methylιmιdazol-2-yl)phenoxy)-4-(2-methyl-5-amιdιnophenoxy(- 1 ,7-dιhydro-6(5 V)-pterιdιnone; 2-(3-dιmethylamιnophenoxy)-4-(3-methyl-4-amιdιnophenoxy)- 1 ,7-dιhydro-6(5A )-pterιdιnone, 5 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy-4-(2-amιno-5-amιdιnophenoxy(- 1 , 7-dιhydro-6(5/V)-pterιdιnone; 2-(3-r-butoxycarbonylphenoxy)-4-(3-amιno-4-amιdιnophenoxy)- 1 , 7-dιhydro-6(5 )-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(2-carboxy-5-amιdιnophenoxy(- 1 ,7-dιhydro-6(δW)-pterιdιnone; 0 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(3-carboxy-4-amιdιnophenoxy)- 1 ,7-dιhydro-6(5/Y)-pteπdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(2-r-butoxycarbonyl-5-amιdιnophenoxy(- 1 ,7-dιhydro-6(5/ )-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(3-r-butoxycarbonyl-4-amιdιnophenoxy)- 5 1 ,7-dιhydro-6(5 - )-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(2-amιnocarbonyl-5-amιdιnophenoxy(- 1 ,7-dιhydro-6(δ )-pterιdιnone; 2-(3-( 1 -methyiιmιdazolιn-2-yl)phenoxy)-4-(3-amιnocarbonyl-4-amιdιnophenoxy)- 1 ,7-dιhydro-6(5 -pterιdιnone; 2-(3 ( 1 methylιmιdazolιn-2-yl)phenoxy)-4-(2-dιmethylamιno δ-amιdιnophenoxy)- 1 ,7-dιhydro-6(5 -/)-pterιdιnone; 5 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(3-dιmethylamιno-4-amιdιnophenoxy(- 1 ,7-dιhydro-6(5 )-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(2-dιmethylamιno-5-amιdιnophenoxy(- 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(3-dιmethylammo-4-amιdιnophenoxy(- 0 1 ,7-dιhydro-6(5W)-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(2-methoxy-δ-amιdιnophenoxy(- 1 ,7-dιhydro-6(δ )-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(2-ethoxy-5-amιdιnophenoxy(- 1 , 7-dιhydro-6(5 )-pterιdιnone; δ 2-(3-( 1 -methylιrnιdazolιn-2-yl)phenoxy)-4-(3-methoxy-5-amιdιnophenoxy(- 1 , 7-dιhydro-6(5/ )-pterιdιnone, 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(3-ethoxy-5-amιdιnophenoxy(- 1 ,7-dιhydro-6(δA )-pterιdιnone; 2-(3-( 1 -methylιmιdazolιn-2-yl)phenoxy)-4-(2-phenoxy-5-amιdιπophenoxy(- 0 1 ,7-dιhydro-6(5/ )-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-phenoxy-δ-amιdιnophenoxy)- 1 ,7-dιhydro-6(5/V)-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-chloro-5-amιdιnophenoxy(- 1 ,7-dιhydro-6(5W)-pterιdιnone; 5 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-bromo-5-amιdιnophenoxy(- 1 , 7-dιhydro-6(5A )-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-methyl-δ-amιdmophenoxy(- 1 ,7-dιhydro-6(5/V)-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-methyl-5-amιdιnophenoxy(- 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-methyl-4-amιdιnophenoxy)- 1 ,7-dιhydro-6(5 y)-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-amιno-5-amιdιnophenoxy(- 1 ,7-dιhydro-6(5/y)-pterιdιnone; δ 2-(3-dιmethylamιnocarbonyiphenoxy)-4-(3-amιno-4-amιdιnophenoxy)- 1 ,7-dιhydro-6(5r*V)-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(2-carboxy-5-amιdιnophenoxy(- 1 , 7-dιhydro-6(5 )-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(3-carboxy-4-amιdmophenoxy)- 1 ,7-dιhydro-6(5 L )-pterιdιnone; 2 (3-guanιdιnophenoxy)-4-(2-f-butoxycarbonyl- 5-amιdιnophenoxy) 1 , 7-dιhydro-6( 5 y)-pteπdιnone, 2-(3-guanιdιnαphenoxy)-4-(3-f-butoxycarbonyl-4-amιdιnophenoxyH ,7-dιhydro-6(6 -/)-pterιdιnone, 2-(3-guanιdιnophenoxy)-4-(2-amιnocarbonyl-5-amιdιnophenoxy)- 1 , 7-dιhydro-6( 5 V)-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(3-amιnocarbonyl-4-amιdιnophenoxy)-1 ,7-dιhydro-6(δ V)-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(3-dιmethylamιno-4-amιdιnophenoxy)-1 , 7-dιhydro-6(δW)-pterιdιnone; 2-( 3-guanιdιnophenoxy)-4-(2-dιmethylamιno-δ-amιdιπophenoxy)-7-rnethyl- 1 ,7-dιhydro-6(δf )-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(3-dιmethylamιno-4-amιdιnophenoxy)-7-( 1 -methylethyl(- 1 ,7-dιhydro-6(5/V)-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-bromo-5-amιdιnophenoxy)-7-(2-methylpropyl(- 1 ,7-dιhydro-6(5 - )-pteπdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-methyl-5-amιdιnophenoxy)-7 ( 1 -methylpropyU- 1 ,7-dιhydro-6(5 V)-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-methyl-5-amιdιnophenoxy)-7-benzyl- 1 ,7-dιhydro-6(5 - )-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-methyl-4-amιdιnophenoxy(- 7-(4-sulfonylphenyl)methyl- 1 ,7-dιhydro-6(5 V)-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-amιno-5-amιdιnophenoxy)-7-(2-methylsulfonyl)ethyl- 1 ,7-dιhydro-6(5 y)-pterιdιnone; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-amιno-4-amιdιnophenoxy)-7-(sulfonylmethyl)- 1 ,7-dιhydro-6(5/ )-pteπdιnone; 2-(3-guanιdιnophenoxy)-4-(2-carboxy-5-amιdιnophenoxy)-7-(ιndolιn-3-yl)methyl- 1 ,7-dιhydro-6(5/ )-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(3-carboxy-4-amιdιnophenoxy)-7-(ιmιdazol-4-yl)rnethyi- 1 ,7-dιhydro-6(5H)-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(2-f-butoxycarbonyl-δ-amιdιnophenoxy)-7-(hydroxymethyD- 1 ,7-dιhydro-6( δW)-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(3-f-butoxycarbonyl-4-amιdιnophenoxy)-7 ( 1 -hydroxyethyD- 1 ,7-dιhydro-6(δ/ )-pteπdιnone; 2-(3-guanιdιnophenoxy)-4-(2-amιnocarbonyl-5-amιdιnophenoxy)-7-(amιnocarbonylmethyl(- 1 ,7-dιhydro-6(5 -- )-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(3-amιnocarbonyl-4-amιdιnophenoxy)-7-(2-(amιnocarbonyl)ethyl) 1 ,7-dιhydro-6(δ y)-pteπdιnone; 2-(3-guanιdιnophenoxy)-4-(2-dιmethylamιno-5-amιdιnophenoxy)-7-(carboxymethyl(- 1 ,7-dιhydro-6(5 -/)-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(3-dιmethylamιno-4-amιdιnophenoxy(-7-(2-carboxyethyl(- 1 ,7-dιhydro-6( 5 y)-pterιdιnone; 2-(3-guanιdιnophenoxy)-4-(2-dιmethylamιno-5-amιdιnophenoxy)-7-(4-amιnobutyD- 2-(3-guaπιdιnophenoxy)-4-(3-dιmethylamιno-4-amιdιnophenoxy)-7-(3-guanιdιnopropyD- 1 ,7-dιhydro-6(5A )-pterιdιnone. E. In a similar manner, 2-(2-benzyloxy-5-amιdιnophenoxy)-4-(3- (dιmethylamιnocarbonyl)phenoxy)-5 τ ' -pyπmιdo[4, 5-Δ][ 1 ,4]oxazm-6(7#)-one (0.1 1 g, 0.1 8 mmol), a compound of formula (T), was treated to afford 0.10 g 2-(2-hydroxy-5- amιdιnophenoxy)-4-(3-(dιmethylamιnocarbonyl)phenoxy)-5 y-pyrιmιdo[4, 5-6] [ 1 ,4]oxazιn-6(7 (- one, a compound of formula (lb), NMR (DMS0-d 6 ) 9.10 (brs,2), 8.80 (brs,2), 7.70 (m, 2) , 7.60 (dd, 1 ) , 7.20-7.40 (m,4), 7.10 (d, 1 2) , 4.90 (s,2) 3.00 (s,3), 2.90 (s,3). F. In a similar manner, the following compounds of formula (lb) are prepared: 2-(2-hydroxy-5-amιdιnophenoxy)-4-(3-(dιethylamιno- carbonyl)phenoxy)-5/y-pyrιmιdo[4, 5-ώ][ 1 ,4]oxazιn-6(7/-r)-one; 2-(2-methoxy-δ-amιdιnophenoxy)-4-(δ-methyl-3-(dιmethyl- amιnocarbonyl)phenoxy)-δ/ -pyrιmιdo{4,5-ώ)[ 1 ,4]oxazιn-6(7/V)-one; 2-(2-ethoxy-5-amιdιnophenoxy)-4-(5-trιfluoromethyl- 3-(dιmethylamιnocarbonyl)phenoxy)-5/ t y-pyrιmιdo[4,5-ώ][1 ,4loxazιπ-6(7 )-one; 2-(2-phenoxy-5-amιdιnophenoxy)-4-(5-methoxy-3-(dιmethylamιnocarbonyl)phenoxy)- δW-pyrιmιdo[4,5-ώ][ 1 ,4]oxazin-6(7/ )-one; 2-(2-chloro-δ-amιdιnophenoxy)-4-(δ-carboxy-3-(dιmethylamιnocarbonyl)phenoxy)- δ -pyrιmιdo[4,5-ώ][ 1 ,4]oxazιn-6(7 y)-one; 2-(2-methyl-δ-amιdιnophenoxy)-4-(5-ethoxycarbonyl-3-methylphenoxy(- 5W-pyrιmιdo[4,5-Δl[ 1 ,4]oxazιn-6(7/y)-one; 2-(2-?-butyl-5-amιdιnophenoxy)-4-(5-dιmethylamιno-3-(ιmιdazolιn-2-yl)phenoxy(- 5 -pyrιmιdo[4, 5-ώl[1 ,4]oxazιn-6(7 y)-one; 2-(2-amιno-5-amιdιnophenoxy)-4-(5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy(- 5H-pyrιmιdo[4, 5-ώ][ 1 ,4loxazιn-6(7 V)-one; 2-(2-carboxy-δ-amιdιnophenoxy)-4-(δ-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxy(- 5W-pyrιmιdo[4,δ-6][1 ,4]oxazιn-6(7/y)-one; 2-(2-benzyloxycarboπy]-δ-amιdinophenoxy)-4-(δ-(2-ethoxycarbonylethyl)-3-(tetrahydropyπmιdιn- 2-yl)phenoxy)-5W-pyπmιdo[4,5-ύ][ 1 ,4]oxazιn-6(7W)-one; 2-(2-dιethylamιnocarbonyl-5-amιdιnophenoxy)-4-(3-(dιethylamιnocarbonyl)phenoxy(- 5W-pyrtmιdo[4, 5-o][ 1 ,4]oxazιn-6(7/V)-one; 2-(2-amιno-5-amιdιnophenoxy)-4-(δ-methyl-3-(dιmethyl-amιnocarbonyl)phenoxy)- 7-methyl-5/V-pyrιmιdo[4,5-ώ][ 1 ,4]oxazιn-6(7/y)-one; 2-(2-hydroxy-5-amιdιnophenoxy)-4-{5-trιfluoromethyl-3-(dιmethyiamιnocarbonyl)phenoxγ(- 7-(1-methylethyl)-5V-pyrιmιdo[4,5-ώ](1,4]oxazιn-6(7 /)-one; 2-(2-methoxy-5-amιdιnophenoxy(-4-(δ-methoxy-3-(dιmethylamιnocarboπyl)phenoxy(- 7-(2-methylpropyl)-5-/-pyrιmιdo[4,δ-6][1 ,4]oxazιn-6(7/ )-one; 2-(2-ethoxy-5-amιdιnophenoxy)-4-(5-carboxy-3-(dιmethylamιnocarbonyl)phenoxy(- 7-(1-methylpropyl)-5y-pyπmιdo[4,5-ό][1 ,4]oxazin-6(7W)-one; 2-(2-phenoxy-5-amιdιnophenoxy)-4-(5-ethoxycarbonyl-3-methylphenoxy)-7-benzyl- 5τ'-pyrιmιdo[4,5-6][1,4]oxazιn-6(7A)-one; 2-(2-chloro-5-amιdιnophenoxy)-4-(5-dιmethylamιno-3-(ιmιdazolιn-2-yl)phenoxy(- 7-(4-sulfonylphenyl)methyl-5-/-pyrιmιdo[4,5-6][1,4]oxazm-6(7A)-one; 2-(2-methyl-5-amιdιnophenoxy)-4-(5-fdιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy)- 7-(sulfonylmethyl)-5 -pyrιmιdo[4,5-6][1,4]oxazιn-6(7A)-one; 2-(2-r-butyl-5-amιdιnophenoxy)-4-(δ-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxy) 7-(ιndolιn-3-yl)methyl-5 t --pyrιmιdo[4,5-6][1 ,4]oxazιπ-6(7V)-one; 2-(2-amιno-5-amιdιnophenoxy)-4-(5-(2-ethoxycarbonyiethyl)-3 (tetrahydropyπmidin- 2-yl)phenoxy)-7-(ιmιdazol-4-yl)methyl-5A-pyrιmιdo[4,5-6][1 ,4]oxazιn 6(7H)-one; 2-(2-carboxy-5-amιdιnophenoxy)-4-(5-carboxy-3-(dιmethylamtnocarbonyl)phenoxy)- 7-(hydroxymethyl)-5 -pyrιmιdo[4,5-o][1,4]oxazιn-6(7/y)-one; 2-(2-benzyloxycarbonyl-5-amιdιnophenoxy)-4-(5-ethoxycarbonyl-3-methylphenoxy)- 7-(1-hydroxyethyl)-δW-pyrιmιdo[4,δ-6][1 ,4]oxazιn-6(7/τ')-one; 2-(2-dιethylamιnocarbonyl-δ-amιdιnophenoxy)-4-(δ-dιmethylamιno-3-(ιmιdazolιn-2-yl)phenoxy(- 7-(amιnocarbonylmethyl)-5A-pyrιmιdo(4,5-6][1 ,4]oxazιn-6(7/V)-one, 2-(2-amιno-δ-amιdιnophenoxy)-4-(5-(dιmethylamιnocarbonyl)methyl-3-(ιmιdazol-2-yl)phenoxy)- 7-{2-(amιnocarbonyl)ethyl)-5A-pyrιmιdo[4,5-ώ][1,4]oxazιn-6(7f)-one; 2-(2-hydroxy-5-amιdιnophenoxy)-4-(5-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxyl- 7-(carboxymethyl)-5A-pyrιmιdo[4,δ-6][1 ,4)oxazιn-6(7 )-one; 2-(2-hydroxy-6-amιdιnophenoxy)-4-(5-(2-ethoxycarboπylethyl)-3-(tetrahydropyrιmιdιn- 2-yl)phenoxy)-7-(2-carboxyethyl)-5W-pyrιmιdo[4, 5-6][ 1,4]oxazιn-6(7/y)-one; 2-(2-hydroxy-5-amιdιnophenoxy)-4-(5-(dιmethylamιnocarbonyl)methyl-(3-(ιmιdazol- 2-yl)phenoxy)-7-(4-amιnobutyl)-5W-pyrιmιdo[4,5-6][1 ,4]oxazιn-6(7-/)-one; and 2-(2-hydroxy-δ-amιdιnophenoxy)-4-(5-(dιmethylamιnoethyl-3-(dιmethylamιnocarbonyl)phenoxy(- 7-(3-guanιdιnopropyl)-5W-pyrιmιdo[4, 5-6111 ,4]oxazιn-6(7/V)-one. G. In a similar manner, 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-benzyloxy- 5-amιdιnophenoxy)-5/-pyπmιdo[4,5-6][1,4]oxazιn-6(7 )-one, a compound of formula (X), is treated to afford 2-(3-dιmethylamιnocarbonylpheπoxy)-4-(2-hydroxy-5-amιdιnophenoxy)-5/y- pyrιmιdo[4,5-6][1,4]oxazιn-6(7/V)-one, a compound of formula (lib). H. In a similar manner, the following compounds of formula (lib) are prepared: 2-(3-methylphenoxy)-4-(2-methoxy-6-amιdιnophenoxy)-5/ -pyrιmιdo[4,5-6][1,4loxazιn- 6(7W)-one, 2-(3-chloro-5-methoxyphenoxy)-4-(2-ethoxy-5-amιdιnophenoxy)-5y-pyrιmιdo[4,δ-6][1 ,4]oxazιn- 6(7 y)-one, 2-(4-trιfluoromethylphenoxy)-4-(3-methoxy-5-amιdιnophenoxy)-5 -pyrιmιdo[4, 5-61(1 ,4]oxazιn- δ 6{7H)-one; 2-(3,5-dιamιnophenoxy)-4-(3-ethoxy-5-amιdιnophenoxy)-5 t y-pyπmιdo[4,5-6][1,4]oxazιn- 6(7H)-one; 2-(3-guanιdιno-5-methylphenoxy)-4-(2-phenoxy-5-amιdιnophenoxy(- δ/-pyrιmιdo(4,δ-6][1,4]oxazιn-6(7W)-one; 0 2-(3-ureιdophenoxy)-4-(3-phenoxy-5-amιdιnophenoxy)-5 /-pyrιmιdo[4,5-6][1 ,4]oxazιn-6(7 t /)-one, 2-(3-(2-chloroethyl)-5-methylphenoxy)-4-(2-chloro-5-amιdιnophenoxy(- 5/-pyrιmιdo[4,5-6][1,4]oxazιn-6(7V)-one; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-bromo-5-amιdιnophenoxy(- 5 --pyrιmιdo[4,5-6][1,4]oxazιn-6(7/y)-one; 5 2 (4 ethoxycarbonylphenoxy)-4-(2-methyl-5-amιdιnophenoxy(- 5/-/-pyrιmιdo[4,5-6][1,4]oxazιn-6(7/-)-one; 2-(3-( 1 -methy midazol 2 yl)phenoxy)-4-(2-methyl-δ-amιdιnophenoxy(- 5 -pyrιmιdo[4,5-6][1,4loxazιn-6(7V)-one; 2-(3-dιmethylamιnophenoxy)-4-(3-methyl-4-amιdιnophenoxy- 0 -δV-pyrιmιdo ' 4,5-6][1 ,4]oxazιn-6(7/Y)-one; 2 (3-( 1 -methylιmιdazolιn-2-yl)phenoxy-4-(2-amιno-5-amιdιnophenoxy(- 5V-pyπmιdo[4,5-6][1,4]oxazιn-6(7#)-one; 2-(3-r-butoxycarbonylphenoxy)-4-(3-amιno-4-amιdιnophenoxy(- 5/V-pyrιmιdo[4,5-6][1 ,4]oxazιn-6(7W)-one; 5 2-(3-(1-methylιmιdazolιn-2-yl)phenoxy)-4-(2-carboxy-5-amιdιnophenoxy(- 5 -pyrιmιdo[4,5-6][1 ,4]oxazin-6{7W)-one; 2-(3-(1 methylιmιdazolιn-2-yl)phenoxy)-4-(3-carboxy-4-amιdιnophenoxy)- 5V-pyrιmιdol4,5-6][ 1 ,4]oxazιn-6(7/V)-one; 2-(3-(1 methylιmιdazolιn-2-yl)phenoxy)-4-(2-f-butoxycarbonyl-5-amιdιnophenoxy)- 0 5/Υ-pyπmιdo[4,δ-6][1 ,41oxazιn-6(7W)-one; 2-(3-(1-methylιmιdazolιn-2-yl)phenoxy)-4-(3-r-butoxycarbonyl-4-amιdιnophenoxy)- 5 -pyrιmιdo[4,5-6][1,4]oxazιn-6(7/)-one; 2-(3-(1-methylιmιdazolιn-2-yl)phenoxy)-4-(2-amιnocarbonyl-5-amιdιπophenoxy)- δ<V-pyrιmιdo(4,δ-6][1,4]oxazιn-6(7W(-one; δ 2-(3-(1-methylιmιdazolιn-2-yl)phenoxy)-4-(3-amιnocarbonyl-4-amιdιnophenoxy(- 5W-pyrιmιdo[4,5-6][1,4]oxazιn-6(7/ t )-one; 2-(3-(1-methylιmιdazolιn-2-yl)phenoxy(-4-(2-dιmethylamιno-5-amιdιnophenoxy(- δ τ f -pyπmιdo[4, 5-61(1 ,4]oxazιn-6(7/y)-one; 2-(3-(1-methylιmιdazolιn-2-yl)phenoxy(-4-(3-dιmethylamιno-4-arnιdιnophenoxy(- 5/-pyrιmιdo[4,5-6][1 ,4]oxazιn-6(7/V)-one; 2-(3-(1-methylιmιdazolιn-2-yl)phenoxy)-4-(2-dιmethylamιno-5-amιdιnophenoxy(- 7-methyl-5 V-pyrιmιdo[4,5-6][1,4]oxazιn-6(7y)-one; 2-(3-(1-methylιmιdazolιn-2-yl)phenoxy)-4-(3-dιmethylamιno-4-amιdιnophenoxy)- 7-(1-methylethyl)-δ/y-pyrιmιdo[4,5-6l[1,4]oxazιn-6(7/y)-one; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-bromo-δ-amιdιnophenoxy)-7-(2-methylpropyl(- 5V-pyrιmιdo[4,5-6][1,4]oxazιn-6(7/)-one; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-methyl-5-amιdιnophenoxy)-7-(1-methylpropyl(- δ/V-pyrιmιdo[4,δ-6][1,4]oxazιn-6(7 )-one; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-methyl-5-amιdιnophenoxy)-7-benzyl- δ/-pyrιmιdof4,δ-6l[1,4]oxazιn-6(7rV)-one; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-methyl-4-amιdιnophenoxy(- 7-(4-sulfonylphenyl)methyl-5 -pyπmιdo(4,6-6][1 ,4]oxazιn-6(7 τ')-one; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-amιno-δ-amιdιnophenoxy)-7-(2-methylsulfonyi)ethyl- 5W-pyrιrτιιdo[4,5-6][1 ,4]oxazιn-6(7W)-one; 2-(3-dιmethylamιnocarbonylphenoxy)-4-(3-amιno-4-amιdιnophenoxy)-7-(sulfonylmethyl)- 5V-pyrιmιdo[4,δ-6][1,4]oxazιn-6(7 )-one; 2-(3-guanιdιnophenoxy)-4-(2-carboxy-δ-amιdιnophenoxy)-7-(ιndolιn-3-yl)methyl- 5Λ-pyrιmιdo(4,5-6][1 ,4]oxazιn-6(7 L )-one; 2-(3-guanιdιnophenoxy)-4-(3-carboxy-4-amιdιnophenoxy)-7-(ιmιdazol-4-yl(methyl- 5/τ'-pyrιmιdo[4,5-6][1,4]oxazιn-6(7V)-one; 2-(3-guanιdιnophenoxy)-4-(2-f-butoxycarbonyl- 5-amιdιnophenoxy )-7-(hydroxy methyl }- 5λ-pyrιmιdo[4,5-6][1 ,4)oxazιn-6(7Aτ')-one; 2-(3-guanιdιnophenoxy)-4-(3-r-butoxycarbonyl-4-amtdιnophenoxy)-7-(1-hydroxyethyl(- 5-r'-pyrιmιdo[4,5-6][1 ,41oxaztn-6(7/V)-one; 2-(3-guanιdιnophenoxy)-4-(2-amιnocarbonyl-5-amιdιnophenoxy(-7-(amιnocarbonylmethyl)- 5 L -pyrιmιdo[4,5-6][1 ,4]oxazιn-6(7/- I ')-one; 2-(3-guanιdιnophenoxy)-4-(3-amιnocarbonyl-4-amιdιnophenoxy)-7-(2-(amιnocarbonyl)ethyl(- 6/V-pyrιmιdo[4, 5-6111,4]oxazιn-6(7/> -one; 2-(3-guanιdιnophenoxy)-4-(2-dιmethylamιno-5-amιdmophenoxy)-7-(carboxymethyl(- 5/-pynmido[4,5-6][1,4]oxazin-6(7W)-one; 2-(3-guanιdιnophenoxy)-4-(3-dιmethylamιno-4-amιdιnophenoxy)-7-(2-carboxyethyl(- 5/V-pyrιmιdo[4,5-6][1 ,4]oxazm-6(7W)-one; 2 (3-guanιdιnophenoxy)-4-(2-dιmethylamιno-5-amιdιnophenoxy)-7-(4-amιnobutyl)- δ/-pyrιmιdo[4,6-6][1 ,4]oxazιn-6(7 )-one; and 2-(3-guanιdιnophenoxy(-4-(3-dιmethylamιno-4-amιdιnophenoxy)-7-(3-guanιdιnopropyl(- 5/-/-pyπmιdo[4, 5-6][ 1 ,4]oxazιn-6(7/V)-one. EXAMPLE 2 This example illustrates the preparation of representative pharmaceutical compositions for oral administration containing a compound of the invention, or a pharmaceutically acceptable salt thereof, e.g. , 2-(2-hydroxy-5-amidinophenoxy)-4-(3-(dιmethylamtnocarbonyl)phenoxy)- 1 ,7- dihydro-βf δ/VJ-pteridinone: A. Ingredients % wt./wt. Compound of the invention 20.0% Lactose 79.5% Magnesium stearate 0.5% The above ingredients are mixed and dispensed into hard-shell gelatin capsules containing 100 mg each. B. Ingredients % wt./wt. Compound of the invention 20.0% Magnesium stearate 0.9% Starch 8.6% Lactose 79.6% PVP (polyvmylpyrrolidine) 0.9% The above ingredients with the exception of the magnesium stearate are combined and granulated using water as a granulating liquid. The formulation is then dried, mixed with the magnesium stearate and formed into tablets with an appropriate tableting machine. C. Ingredients Compound of the invention 0.1 g Propylene glycol 20.0 g Polyethylene glycol 400 20.0 g Polysorbate 80 1 .0 g Water q.s. 1 00 mL The compound of the invention is dissolved in propylene glycol, polyethylene glycol 400 and polysorbate 80. A sufficient quantity of water is then added with stirring to provide 100 mL of the solution which is filtered and bottled. D. Ingredients % wt./wt. Compound of the invention 20.0% Peanut Oil 78.0% Span 60 2.0% The above ingredients are melted, mixed and filled into soft elastic capsules. E. Ingredients % wt./wt Compound of the invention 1 .0% Methyl or carboxymethyi cellulose 2.0% 0.9% saline q.s. 1 00 L The compound of the invention is dissolved in the cellulose/saline solution, filtered and bottled for use. EXAMPLE 3 This example illustrates the preparation of a representative pharmaceutical formulation for parenteral administration containing a compound of the invention, or a pharmaceutically acceptable salt thereof, e.g. , 2-(2-hydroxy-5-amιdιnophenoxy)-4-(3- (dιmethylamιnocarbonyl(phenoxy)- l ,7-dιhydro-6( δA (-pterιdιnone: Ingredients Compound of the invention 0.02 g Propylene glycol 20 0 g δ Polyethylene glycol 400 20 0 g Polysorbate 80 1 0 g 0.9% Saline solution q s 100 mL The compound of the invention is dissolved in propylene glycol, polyethylene glycol 400 and polysorbate 80. A sufficient quantity of 0.9% saline solution is then added with stirring to 0 provide 100 mL of the I.V. solution which is filtered through a 0.2 μ membrane filter and packaged under sterile conditions. EXAMPLE 4 This example illustrates the preparation of a representative pharmaceutical composition in suppository form containing a compound of the invention, or a pharmaceutically acceptable 5 salt thereof, e.g. , 2-(2-hydroxy-5-amιdιnophenoxy)-4-(3-(dιmethylamιnocarbonyl)phenoxy)-1 ,7- dιhydro-6(δ )-pterιdιnone: Ingredients % wt./wt. Compound of the invention 1 .0% Polyethylene glycol 1000 74.5% 0 Polyethylene glycol 4000 24.5% The ingredients are melted together and mixed on a steam bath, and poured into molds containing 2.5 g total weight. EXAMPLE 5 This example illustrates the preparation of a representative pharmaceutical formulation for insufflation containing a compound of the invention, or a pharmaceutically acceptable salt thereof, e.g. , 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-hydroxy-5-amιdιnophenoxy)-1 , 7- dιhydro-6(δ )-pteπdιnone: Ingredients % wt./wt. δ Micronized compound of the invention 1 .0% Micronized lactose 99.0% The ingredients are milled, mixed, and packaged in an insufflator equipped with a dosing pump. EXAMPLE 6 0 This example illustrates the preparation of a representative pharmaceutical formulation in nebulized form containing a compound of the invention, or a pharmaceutically acceptable salt thereof, e.g , 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-hydroxy-δ-amιdιnophenoxy)- 1 ,7- dιhydro-6(δ - )-pterιdιnone: Ingredients % wt./wt. δ Compound of the invention 0.006 % Water 89.995% Ethanol 1 0.000% The compound of the invention is dissolved in ethanol and blended with water. The formulation is then packaged in a nebulizer equipped with a dosing pump. 0 EXAMPLE 7 This example illustrates the preparation of a representative pharmaceutical formulation in aerosol form containing a compound of the invention, or a pharmaceutically acceptable salt thereof, e.g. , 2-(3-dιmethylamιnocarbonylphenoxy)-4-(2-hydroxy-5-amιdιnophenoxy)-1 ,7- dιhydro-6(δ y)-pterιdιnone: δ Ingredients % wt./wt. Compound of the invention 0.10% Propellant 1 1 /1 2 98.90% Oleic acid 1 .00% The compound of the invention is dispersed in oleic acid and the propellents. The 0 resulting mixture is then poured into an aerosol container fitted with a metering valve EXAMPLE 8 (In vitro assay for Factor Xa, Thrombin and Tissue Plasminogen Activator) This assay demonstrates the activity of the compounds of the invention towards factor Xa, thrombin and tissue plasminogen activator. The activities were determined as an initial rate of cleavage of the peptide p-nitroanilide by the enzyme. The cleavage product, p-nitroanilme, absorbs at 405 nm with a molar extinction coefficient of 9920 M ' cm " ' . Reagents and Solutions: Dimethyl sulfoxide (DMSOt (Baker analyzed grade) . Assay buffer: 60 mM TrisHCI, 1 50 mM NaCI, 2.5 mM CaCI 2 , and 0.1 % polyethylene glycol 6000, pH 7.5. Enzymes (Enzyme Research Lab.) : 1 . Human factor Xa stock solution: 0.281 mg/mL in assay buffer, stored at -80°C (working solution (2X) : 106 ng/mL or 2 nM in assay buffer, prepare prior to use) . 2. Human thrombin stock solution: Stored at -80°C (working solution (2X) : 1 200 ng/mL or 40 nM in assay buffer, prepare prior to use). 3. Human tissue plasminogen activator (tPA) (Two chains, Sigma) stock solution : 1 mg/mL, stored at -80 °C (working solution (2X) : 1 361 ng/mL in assay buffer, prepare prior to use). Chromogenic substrates (Pharmacia Hepar Inc.) : 1 . S2222 (FXa assay) stock solution: 6 mM in dH 2 0, store at 4°C (working solution (4X) : 656 μM in assay buffer). 2. S2302 (Thrombin assay) stock solution: 10 mM in dH 2 0, stored at 4°C (working solution (4X) : 1 200 μ in assay buffer) . 3. S2288 (tPA assay) stock solution: 1 0 mM in dH 2 0, stored at 4 °C (working solution (4X) : 1484 μ in assay buffer) . (All substrate working solutions were prepared on assay day 5.) Standard inhibitor compound stock solution: δ mM in DMSO, stored at -20°C. Test compounds (compounds of the invention) stock solutions: 10 mM in DMSO, stored at -20°C. Assay procedure: Assays were performed in 96-well microtiter plates in a total volume of 200 μl . Assay components were in final concentration of 60 mM TrisHCI, 1 60 mM NaCI, 2.6 mM CaCI 2 , 0.1 % polyethylene glycol 6000, pH 7.5, in the absence or presence of the standard inhibitor or the test compounds and enzyme and substrate at following concentrations: ( 1 ) 1 nM factor Xa and 1 64 μM S2222; (2) 20 nM thrombin and 300 μM S2302; and (3) 10 nM tPA and 371 μM S2288. Concentrations of the standard inhibitor compound in the assay were from 5 μM to 0.021 μM in 1 to 3 dilution . Concentration of the test compounds in the assay typically were from 10 μM to 0.041 μM in 1 to 3 dilution. For potent test compounds, the concentrations used in the factor Xa assay were further diluted 1 00 fold ( 100 nM to 0.41 nM) or 1 000 fold ( 10 nM to 0.041 nM) . All substrate concentrations used are equal to their K m values under the present assay conditions. Assays were performed at ambient temperature. The first step in the assay was the preparation of 1 0 mM test compound stock solutions in DMSO (for potent test compounds, 10 mM stock solutions were further diluted to 0.1 or 0.01 mM for the factor Xa assay), followed by the preparation of test compound working solutions (4X) by a serial dilutions of 10 mM stock solutions with Biomek 1000 (or Multiprobe 204) in 96 deep well plates as follows: (a) Prepare a 40 μM working solution by diluting the 1 0 mM stock 1 to 2δ0 in assay buffer in 2 steps: 1 to 100, and 1 to 2.5. (b) Make another five serial dilutions ( 1 :3) of the 40 μM solution (600 μl for each concentration) . A total of six diluted test compound solutions were used in the assay Standard inhibitor compound (5 mM stock) or DMSO (control) went through the same dilution steps as those described above for test compounds. The next step in the assay was to dispense 50 μl of the test compound working solutions (4X) (from 40 μM to 0.164 M) in duplicate to microtiter plates with Biomek or MP204 To this was added 100 μl of enzyme working solution (2X) with Biomek or MP204. The resulting solutions were incubated at ambient temperature for 10 minutes. To the solutions was added 50 μl of substrate working solution (4X) with Biomek or MP204. The enzyme kinetics were measured at 405 nm at 1 0 seconds intervals for five minutes in a THERMOmax plate reader at ambient temperature. Calculation of K, of the test compounds: Enzyme rates were calculated as mOD/min based on the first two minutes readings. The IC go values were determined by fitting the data to the log-logit equation (linear) or the Morrison equation (non-linear) with an EXCEL spread-sheet. Ki values were then obtained by dividing the IC 50 by 2. Routinely, Kiffactor Xa) values less than 3 nM were calculated from the Morrison equation. Compounds of the invention, when tested in this assay, demonstrated the selective ability to inhibit human factor Xa and human thrombin. EXAMPLE 9 (In vitro assay for Human Prothrombinase) This assay demonstrates the ability of the compounds of the invention to inhibit prothrombinase. Prothrombinase (PTase) catalyzes the activation of prothrombm to yield fragment 1 .2 plus thrombin with meizothrombin as the intermediate. This assay is an end point assay. Activity of the prothrombinase is measured by activity of thrombin (one of the reaction products) or by the amount of thrombin formed/time based on a thrombin standard curve (nM vs mOD/min) . For determination of IC 50 (PTase) of the compounds of the invention, PTase activity was expressed by thrombin activity (mODimin) . Materials: Enzymes: δ 1 . Human factor Va (Haematologic Technologies Inc., Cat# HCVA-01 1 0) working solution: 1 .0 mg/mL in 50% glycerol, 2 mM CaCI 2 , stored at -20°C. 2. Human factor Xa (Enzyme Res. Lab. cat# HFXa101 1 ) working solution: 0.281 mg/mL in assay buffer (without BSA), stored at -80°C. 3. Human prothrombin (Fll) (Enzyme Res. Lab. , Cat# HP1002) working solution: 0 Diluted Fll to 4.8δ mg/mL in assay buffer (without BSA) , stored at -80°C. Phosphohpid (PCPS) vesicles: PCPS vesicles (80%PC. 20%PS) were prepared by modification of the method reported by Barenholz er a/. , Biochemistry (1977), Vol. 1 6, pp. 2806-2810. Phosphatidyl senne (Avanti Polar Lipids, Inc., Cat#840032) : δ 1 0 mg/mL in chloroform, purified from brain, stored -20°C under nitrogen or argon. Phosphatidyl Choline (Avanti Polar Lipids, Inc., Cat# 850457): 50 mg/ml in chloroform, synthetic 1 6:0- 1 8: 1 Palmitoyl-Oleoyl , stored at -20 °C under nitrogen or argon. 0 Spectrozyme-TH (American Diagnostica Inc. , Cat# 238L, 50 μmoles, stored at room temperature) working solution: Dissolved 50 μmoles in 10 mL dH 2 0. BSA (Sigma Chem Co. , Cat# A-7888, FractionV, RIA grade) . Assay buffer: 50 mM TrisHCI, pH 7.5, 1 50 mM NaCI, 2.5 mM CaCI 2 , 0.1 % PEG 6000 (BDH) , 0.05% BSA (Sigma, Fr.V, RIA grade) . 5 For one plate assay, prepare the following working solutions: 1 . Prothrombinase complex: (a) 1 00 μM PCPS (27.5 μl of PCPS stock (4.36 mM) diluted to final 1 200 μl with assay buffer. (b) 25 nM Human factor Va: 5.08 μl of Va stockd mg/mL) was diluted to final 0 1 200 μl with assay buffer. (c) 5 pM Human factor Xa: Dilute Xa stock (0.281 mg/mL) 1 : 1 ,220,000 with assay buffer. Prepare at least 1 200 μl. Combine equal volumes (1 100 μl) of each component in the order of PCPS, Va and Xa Let stand at ambient temperature for 6 to 10 minutes and use immediately or store in ice 5 (bring to ambient temperature before use) . 2. 6 μM Human prothrombin (Fll) : dilute 1 24 μL of Fll stock (4.85 mg/mL) to final 1400 μL with assay buffer. 3. 20 mM EDTA/Assay buffer- 0.8 mL of 0.5 M EDTA (pH 8 5) plus 1 9.2 mL assay buffer 4 0 2 mM Spectrozyme-TH/EDTA buffer. 0.44 mL of SPTH stock ( δ mM) plus 1 0.66 mL of 20 mM EDTA/assay buffer, δ. Test compounds (compounds of the invention): δ Prepare a working solution (5X) from 10 mM stock (DMSO) and make a series of 1 :3 dilution. Compounds were assayed at 6 concentrations in duplicate. Assay conditions and procedure: Prothrombinase reaction was performed in final 50 μL of mixture containing PTase (20 μM PCPS, 5 nM hFVa, and 1 pM hFXa), 1 .2 μM human factor II and varied concentration of 0 the test compounds (5 μM to 0.021 μM or lower concentration range) Reaction was started by addition of PTase and incubated for 6 minutes at room temperature. Reaction was stopped by addition of EDTA/buffer to final 10 mM Activity of thrombin (product) was then measured in the presence of 0.1 mM of Spectrozyme-TH as substrate at 405 nm for 5 minutes (10 seconds intervals) at ambient temperature in a THEROmax microplate reader Reactions were performed 5 in 96-well microtiter plates In the first step of the assay, 10 μl of diluted test compound (5X) or buffer was added to the plates in duplicate Then 10 μl of prothombin (hFII) (5X) was added to each well. Next 30 μl PTase was added to each well, mix for about 30 seconds. The plates were then incubated at ambient temperature for 6 minutes. 0 In the next step, 60 μl of 20 mM EDTA (in assay buffer) was added to each well to stop the reaction. The resulting solutions were then mixed for about 10 seconds Then 100 μl of 0.2 mM spectrozyme was added to each well. The thrombin reaction rate was then measured at 406 nm for δ minutes at 1 0 seconds intervals in a Molecular Devices microplate reader Calculations: 6 Thrombin reaction rate was expressed as mOD/min. using OD readings from the five minute reaction. IC 50 values were calculated with the log-logit curve fit program. The compounds of the invention demonstrated the ability to inhibit pro-thrombmase when tested in this assay. EXAMPLE 10 0 (In vivo assay) The following assay demonstrates the ability of the compounds to act as anti-coagulants. Male rats (250-330 g) were anesthetized with sodium pentobarbital (90 mg/kg, i .p.) and prepared for surgery. The left carotid artery was cannulated for the measurement of blood 5 pressure as well as for taking blood samples to monitor clotting variables (prothrombin time (PT) and activated partial thromboplastm time (aPTT)) . The tail vein was cannulated for the purpose of administering the test compounds (i. e. , the compounds of the invention and standards) and the thromboplastm infusion. The abdomen was opened via a mid-line incision and the abdominal vena cava was isolated for 2-3 cm distal to the renal vein. All venous branches in this 2-3 cm segment of the abdominal vena cava were gated . Following all surgery, the animals were allowed to stabilize prior to beginning the experiment. Test compounds were administered as an intravenous bolus (t = 0) . Three minutes later (t = 3), a 5-mιnute infusion of thromboplastm was begun. Two minutes into the infusion (t = δ), the abdominal vena cava was ligated at both the proximal and distal ends. The vessel was left in place for 60 minutes, after which it was excised from the animal, slit open, the clot (if any) carefully removed , and weighed. Statistical analysis on the results was performed using a Wilcoxin-matched-pairs signed rank test The compounds of the invention, when tested in this assay, demonstrated the ability to inhibit the clotting of blood. * # * * * While the present invention has been described with reference to the specific embodiments thereof, it should be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the true spirit and scope of the invention. In addition, many modifications may be made and equivalents may be substituted without departing from the true spirit and scope of the invention. In addition, many modifications may be made to adapt a particular situation, material, composition of matter, process, process step or steps, to the objective, spirit and scope of the present invention All such modifications are intended to be within the scope of the claims appended hereto

Claims: WHAT IS CLAIMED IS: 1 . A compound selected from the group consisting of the following formulae: a n d wherein: A is -0-, -N(R 5 )-, or -S(0) n - (where n is 0, 1 or 2); δ Z 1 and Z 2 are independently -0-, -N(R 5 )- or -OCH 2 -; R 1 and R 4 are each independently hydrogen, halo, alkyl, -OR 8 , -C(0)OR 8 , -C(0)N(R 8 )R 9 , -N(R 8 )R 9 , -N(R 8 )C(0)R 9 , or -N(H)S(0) 2 R 1 1 ; R 2 is -C(NH)NH 2 , -C(NH)N(H)OR 8 , -C(NH)N(H)C(0)OR 1 -C(NH)N(H)C(0)R 8 , -C(NH)N(H)S(0) 2 R 1 1 , or -C(NH)N(H)C(0)N(H)R 8 ; 0 R 3 is halo, alkyl, haloalkyl, haloalkoxy, cyano, ureido, guanidino, -OR 8 , -C(NH)NH 2 , -C(NH)N(H)OR 8 , -C(0)N(R 8 )R 9 , -R 10 -C(O)N(R 8 )R 9 , -CH(OH)C(0)N(R 8 )R 9 , -N(R 8 )R 9 , -R 10 -N(R 8 )R 9 , -C(0)0R 8 , -R 10 -C(O)OR 8 , -N(R 8 )C(0)R 8 , (1 ,2)-tetrahydropyrιmιdιnyl (optionally substituted by alkyl) , ( 1 ,2)-ιmιdazolyl (optionally substituted by alkyl) , or ( 1 ,2)-ιmιdazolinyl (optionally substituted by alkyl); 5 each R 5 is hydrogen, alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl); R 6 is hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl , cycloalkyl, cycloalkylalkyl, -C(0)OR 8 , -R 1 0 -C(O)OR 8 , -R 10 -C(O)N(R 8 )R 9 , -C(O)-R 1 0 -N(R 8 )R 9 , -R 1 0 C(0)R 8 , -R 1 0 -C(O)N( R 8 )N(R 8 )R 9 , -R 1 0 -C(R 8 )(OR 9 )-R 10 N(R 8 )(R 9 ), -C(R 8 ) (OR 8 )C(0)OR 9 , -R 1 0 -C(R 8 ) (C(O)OR 9 ) 2 , -C(R 8 ) (N(R 8 )R 9 )C(0)OR 8 , -R 10 -C(R 8 ) (N(R 8 )R 9 )C(O)OR 8 , -C(R 8 )(OR 8 )R 9 , -R 1 0 -N(R 8 )R 9 , -R 1 0 -N(R 8 )C(O)OR 1 1 , -R 1 0 -N(R 8 ) C(O)R 9 , -R 1 0 -N(R 8 )C(NR 8 )R 1 1 , -R l 0 -N(R 8 )S(O) 2 R 1 1 , -R 10 -N(R 8 )C(O)N(R 8 )R 9 , -R 1 0 -N(R 8 )C(NR 8 )N(R 8 )R 9 , -R 1 0 -N(R 8 )C(NR 8 )N(R 8 )N(R 8 )R 9 , -R 1 0 -N(R 8 )-R 1 0 -C(R 8 )(N(R 8 )R 9 )C(O)OR 8 , -R 10 -N(R 8 )S(O)R 9 , -R 1 0 OR 8 , -R 1 0 -ON(R 8 )C(NR 8 )N(R 8 )R 9 , -R 1 0 -OS(0) 2 OR 8 , -R 1 0 -P(O)(OR 8 )R 9 , -R 1 0 -OP(O)(OR 8 ) 2 , -R 10 -P(0)(OR 8 ) 2 , -R 10 -SR 8 , -R 1 0 -S-R 1 0 -C(0)OR 8 , -R 1 0 -S-R 1 0 -N(R 8 )R 9 , -R 10 -S-R 1 0 -C(R 8 )(N(R 8 )R 9 )C(O)OR 8 , -R 10 -S-R l 0 -N(R 8 )C(O)OR 8 , -R 10 -S-R 0 -N(R 8 )C(O)R 8 , -R 1 0 -S-S-R 1 0 -C(R 8 )(N(R 8 )R 9 )C(0)OR 8 , -R 1 0 -SC(O)N(R 8 )R 9 , -R 1 0 -SC(S)N(R 8 )R 9 , -R 10 -S(0)R 8 , -R 0 -S(0) 2 R 1 1 , -R 10 -S(0)OR 8 , -R 1 0 -S(O) 2 OR 8 , -R 1 0 -S(O) 2 N(R 8 )R 9 , -R 1 0 -S(O)(NR 8 )R 9 , or R 6 is aryl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 -N(R 8 )R 9 , C(0)OR 8 , -C(0)N(R 8 )R 9 , -S(0) 2 OR a and -OP(0)(OR 8 ) 2 ); or R 6 is aralkyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -N(R 8 )R 9 , -C(0)OR 8 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -0P(0)(0R 8 ) 2 ); or R 6 is heterocyclyl (optionally substituted by one or more substituents selected from the group consisting of alkyl , halo, haloalkyl, haioalkoxy, aralkyl, -OR 8 , -C(0)OR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -0P(0)(0R 8 ) 2 ); or R 6 is heterocyclylalkyl (where the heterocyclyl radical is optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, aralkyl, -OR 8 , -SR 8 , -C(0)OR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 ) , -S(0) 2 OR 8 and -0P(0)(0R 8 ) 2 ); or R 6 is adamantyl (optionally substituted by alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -C(0)0R 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -OP(0)(OR 8 ) 2 ); or R 6 is adamantylalkyl (where the adamantyl radical is optionally substituted by alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -C(0)OR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -0P(0)(0R 8 ) 2 ); R 7 is hydrogen, alkyl, cycloalkyl, aralkyl or aryl; each R 8 and R 9 is independently hydrogen, alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl , or dialkylaminocarbonyl); R 1 0 is a straight or branched alkylene chain; and R 1 1 is alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, am o, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, amino, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl) ; as a single stereoisomer or a mixture thereof; or a pharmaceutically acceptable salt thereof. 2. The compound of Claim 1 wherein Z 1 and Z 2 are both -0-; R 1 and R 4 are each independently hydrogen, halo or -OR 8 ; R 2 is -C(NH)NH 2 , -C(NH)N(H)S(0) 2 R 1 1 or -C(NH)N(H)C(0(N(H)R 8 ; R 3 is ureido, guanidino, -OR 8 , -C(0)N(R 8 )R 9 , -N(R 8 )R 9 , -C(0)OR 8 , -N(R 8 ) C(0)R 8 , ( 1 , 2)-tetrahydropyrιmιdιnyl (optionally substituted by alkyl), ( 1 ,2)-ιmιdazolyl (optionally substituted by alkyl), or ( 1 ,2)-ιmιdazolιnyl (optionally substituted by alkyl); each R 5 is hydrogen, alkyl, aryl (optionally substituted by halo), or aralkyl (optionally substituted halo); R 6 is hydrogen, alkyl, -R 1 0 -C(0)OR 8 , -R 1 0 -C(O)N(R 8 )R 9 , -R 1 0 -C(R 8 )(C(O)OR 9 ) 2 , -R 1 0 -N(R 8 )R 9 , -R 1 0 -N(R 8 )C(NR 8 )R 1 1 , -R 1 0 -N(R 8 )C(O)N(R 8 )R 9 , -R 10 -N(R 8 )C(NR 8 )N(R 8 )R 9 , -R 1 0 OR 8 , -R 10 -OP(O)(OR 8 ) 2 , -R 1 0 -SR 8 , or -R 10 -S(O) 2 R 1 1 ; or R 6 is aryl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy and -OR 8 ); or R 6 is aralkyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy and -OR 8 ); or R 6 is heterocyclyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy and -OR 8 ); or R 6 is heterocyclylalkyl (where the heterocyclyl radical is optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy or -OR 8 ); R 7 is hydrogen, alkyl, cycloalkyl, aralkyl or aryl; each R 8 and R 9 is independently hydrogen, alkyl, aryl (optionally substituted by halo, alkyl, hydroxy or alkoxy), or aralkyl (optionally substituted by halo, alkyl, hydroxy or alkoxy); R 1 0 is a straight or branched alkylene chain; and R 11 is alkyl, aryl (optionally substituted by halo, alkyl, hydroxy or alkoxy), or aralkyl (optionally substituted by halo, alkyl, hydroxy or alkoxy). 3. The compound of Claim 2 wherein Z 1 and Z 2 are both -0-; R 1 and R 4 are each independently hydrogen or -OR 8 ; R 3 is -C(0)N(R 8 )R 9 , (1,2)-tetrahydropyrιmιdιnyl (optionally substituted by alkyl), (1,2)-ιmιdazolyl (optionally substituted by alkyl), or (1 ,2)-ιmιdazolιnyl (optionally substituted by alkyl), each R 5 is hydrogen, alkyl, aryl (optionally substituted by halo), or aralkyl (optionally substituted halo); R 6 is hydrogen, alkyl, -R 10 -C(O)OR 8 , -R 10 -C(O)N(R 8 )R 9 , -R 10 -C(R 8 )(C(O)OR 9 ) 2 , -R 10 -N(R 8 )R 9 , -R 10 -N(R 8 )C(NR 8 )R 11 , -R 10 -N(R 8 )C(O)N(R 8 )R 9 , -R 10 -N(R 8 )C(NR 8 )N(R 8 )R 9 , -R 10 OR 8 , -R 10 -0P(O)(OR 8 ) 2 , -R 10 -SR 8 , or -R 10 -S(O) 2 R 11 , or R 6 is aralkyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy and -OR 8 ), or R 6 is imidazolylalkyl or indolylalkyl; R 7 is hydrogen or alkyl; each R 8 and R 9 is independently hydrogen, alkyl, aryl, or aralkyl; R 10 is a straight or branched alkylene chain; and R 11 is alkyl or aryl. 4. The compound of Claim 3 wherein: R 3 is -C(0)N(R 8 )R 9 , (1,2)-ιmιdazolyl (optionally substituted by methyl), or (1 ,2)-ιmιdazolιnyl (optionally substituted by methyl); each R 5 is hydrogen, alkyl, aryl or aralkyl; R 6 is hydrogen, alkyl, -R 10 -C(O)OR 8 , -R 10 -C(O)N(R 8 )R 9 , -R 10 -C(R 8 )(C(O)OR 9 ) 2 , -R 10 -N(R 8 )R 9 , -R 10 -N(R 8 )C(NR 8 )R 11 , -R 10 -N(R 8 )C(0)N(R 8 )R 9 , -R 10 -N(R 8 )C(NR 8 )N(R 8 )R 9 , -R 10 OR 8 , -R 10 -OP(O)(0R 8 ) 2 , -R 10 -SR 8 , or -R 10 -S(O) 2 R 1 '; or R 6 is aralkyl (optionally substituted by one or more substituents selected from the group consisting of methyl and hydroxy); or R 6 is imidazolylalkyl or indolylalkyl; R 7 is hydrogen or alkyl; each R 8 and R 9 is independently hydrogen, alkyl, aryl, or aralkyl; R 10 is a straight or branched alkylene chain; and R 1 1 is alkyl or aryl. 5. The compound of Claim 4 wherein A is -N(H)-; Z 1 and Z 2 are both -0-; R 1 is hydroxy; R 2 is -C(NH)NH 2 ; R 3 is -C(0)N(CH 3 ) 2 ; and R 4 , R 5 , R 6 , and R 7 are hydrogen. δ 6. The compound of Claim 5 selected from formula (I), namely, 2-(2-hydroxy- 5-amιdιnophenoxy)-4-(3-(dimethylamιnocarbonyl)phenoxy)- 1 ,7-dihydro-6(5 )-pterιdinone. 7. The compound of Claim 5 selected from formula (II), namely, 2-(3- dimethylaminocarbonylphenoxy)-4-(2-hydroxy-5-amidinophenoxy)- 1 ,7-dιhydro-6(5 )-pterιdιnone. 8. The compound of Claim 2 wherein: Z 1 and Z 2 are both -0-; R 1 and R 4 are each independently hydrogen or -OR 8 ; R 3 is -C(0)N(R 8 )R 9 , ( 1 ,2)-tetrahydropyrιmιdιnyl (optionally substituted by alkyl) , ( 1 , 2)-ιmιdazolyl 5 (optionally substituted by alkyl) , or ( 1 ,2)-ιmidazolinyl (optionally substituted by alkyl); R 5 is hydrogen, alkyl, aryl (optionally substituted by halo) , or aralkyl (optionally substituted halo); R 6 is hydrogen, alkyl, -R 1 0 -C(O)OR 8 , -R 10 -C(0)N(R 8 )R 9 , -R 1 0 -C(R 8 )(C(O)OR 9 ) 2 , -R 0 -N(R 8 )R 9 , -R 1 0 -N(R 8 )C(NR 8 )R ' 1 , -R 1 0 -N(R 8 )C(O)N(R 8 )R 9 , -R 1 0 -N(R 8 )C(NR 8 )N(R 8 )R 9 , -R 1 0 0R 8 , 0 -R 1 0 -OP(O)(OR 8 ) 2 , -R 1 0 -SR 8 , or -R 1 0 -S(O) 2 R 1 1 ; or R 6 is aralkyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy and -OR 8 ); or R 6 is imidazolylalkyl or indolylalkyl; R 7 is hydrogen or alkyl; 5 each R 8 and R 9 is independently hydrogen, alkyl, aryl, or aralkyl; R 1 0 is a straight or branched alkylene chain; and R 1 1 is alkyl or aryl. 9. The compound of Claim 8 wherein: R 3 is -C(0)N(R 8 )R 9 , ( 1 ,2)-imidazolyl (optionally substituted by methyl), or ( 1 ,2)-ιmιdazolinyl (optionally substituted by methyl); R 5 is hydrogen, alkyl, aryl or aralkyl; R 6 is hydrogen, alkyl, -R 1 0 -C(O)OR 8 , -R 1 0 -C(O)N(R 8 )R 9 , -R 10 -C(R 8 ) (C(0)OR 9 ) 2 , -R 1 0 -N(R 8 )R 9 , -R 1 0 -N(R 8 )C(NR 8 )R 1 1 , -R 1 0 -N(R 8 )C(O)N(R 8 )R 9 , -R 1 0 -N(R 8 )C(NR 8 )N(R 8 )R 9 , -R 1 0 OR 8 , -R 1 0 -OP(O)(OR 8 ) 2 , -R 10 -SR 8 , or -R 1 0 -S(O) 2 R 1 1 ; or R 6 is aralkyl (optionally substituted by one or more substituents selected from the group consisting of methyl and hydroxy); or R 6 is imidazolylalkyl or indolylalkyl; R 7 is hydrogen or alkyl; each R 8 and R 9 is independently hydrogen, alkyl, aryl, or aralkyl; R 10 is a straight or branched alkylene chain; and R 1 1 is alkyl or aryl. 10. The compound of Claim 9 wherein A is -0-; Z 1 and Z 2 are both -0-; R 1 is hydroxy; R 2 is -C(NH)NH 2 ; R 3 is -C(0)N(CH 3 ) 2 ; and R 4 , R 5 , R 6 , and R 7 are hydrogen. 1 1 . The compound of Claim 10 selected from formula (I), namely, 2-(2-hydroxy-5- amιdιnophenoxy)-4-(3-(dιmethylamιnocarbonyl)phenoxy)-5/ -pyπmιdof4,5-6][ 1 ,4]oxazιn-6(7/ >- one. 1 2. A pharmaceutical composition useful in treating a human having a disease-state characterized by thrombotic activity, which composition comprises a therapeutically effective amount of a compound selected from the group consisting of the following formulae: α n α wherein: A is -0-, -N(R 5 )-, or -S(0) n - (where n is 0, 1 or 2); Z 1 and Z 2 are independently -0-, -N(R 5 )- or -0CH 2 -; R 1 and R 4 are each independently hydrogen, halo, alkyl, -OR 8 , -C(0)OR 8 , -C(0)N(R 8 )R 9 , -N(R 8 )R 9 , -N(R 8 )C(0)R 9 , or -N(H)S(0) 2 R 1 1 ; R 2 is -C(NH)NH 2 , -C(NH)N(H)OR 8 , -C(NH)N(H(C(0)OR 1 1 , -C(NH)N(H)C(0)R 8 , -C(NH)N(H)S(0) 2 R 1 * , or -C(NH)N(H)C(0)N(H)R 8 ; R 3 is halo, alkyl, haloalkyl, haloalkoxy, cyano, ureido, guanidino, -OR 8 , -C(NH)NH 2 , -C(NH)N(H)OR 8 , -C(0)N(R 8 )R 9 , -R 1 0 -C(O)N(R 8 )R 9 , -CH(OH)C(0)N(R 8 )R 9 , -N(R 8 )R 9 , -R 10 -N(R 8 )R 9 , -C(0)0R 8 , -R 1 0 -C(O)0R 8 , -N(R 8 )C(0)R 8 , (1 ,2)-tetrahydropyrimιdiπyl (optionally substituted by alkyl), ( 1 ,2)-imidazolyl (optionally substituted by alkyl), or ( 1 ,2)-ιmιdazolinyl (optionally substituted by alkyl); each R 5 is hydrogen, alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, am o, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl); R 6 is hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, cycloalkyl, cycloalkylalkyl, -C(0)OR 8 , -R 10 -C(0)OR 8 , -R 10 -C(0)N(R 8 )R 9 , -C(0)-R 10 -N(R 8 )R 9 , -R 10 -C(O)R 8 , -R 1 0 -C(O)N(R 8 )N(R 8 )R 9 , -R 1 0 -C(R 8 )(OR 9 )-R 1 0 -N(R 8 )(R 9 ), -C(R 8 )(OR 8 IC(0)OR 9 , -R 10 -C(R 8 )(C(O)OR 9 ) 2 , -C(R 8 )(N(R 8 )R 9 )C(0)OR 8 , -R 10 -C(R 8 )(N(R 8 )R 9 )C(O)OR 8 , -C(R 8 )(OR 8 )R 9 , -R 1 0 -N(R 8 )R 9 , -R 10 -N(R 8 )C(O)OR 1 ' , -R 1 0 -N(R 8 )C(O)R 9 , -R 10 -N(R 8 )C(NR 8 )R 1 1 , -R 10 -N(R 8 )S(O) 2 R 1 1 , -R 10 -N(R 8 )C(O(N(R 8 )R 9 , -R 1 0 -N(R 8 )C(NR 8 )N(R 8 )R 9 , -R 1 0 -N(R 8 )C(NR 8 )N(R 8 )N(R 8 )R 9 , -R 10 -N(R 8 )-R 10 -C(R 8 )(N(R a )R 9 )C(O)OR 8 , -R 1 0 -N(R 8 )S(O)R 9 , -R 10 OR 8 , -R 1 0 -ON(R 8 )C(NR 8 )N(R 8 )R 9 , -R ' °-OS(0) 2 OR 8 , -R 1 0 -P(O)(OR 8 )R 9 , -R 1 0 -OP(O)(OR 8 ) 2 , -R 1 0 -P(O)(OR 8 ) 2 , -R 1 0 -SR 8 , -R 1 0 -S-R 10 -C(O)OR 8 , -R 10 -S-R '°-N(R 8 )R 9 , -R 1 0 -S-R 10 -C(R 8 )(N(R 8 )R 9 )C(O)OR 8 , -R , 0 -S-R 1 0 -N(R 8 )C(O)OR 8 , -R 1 0 -S-R 1 0 -N(R 8 )C(O)R 8 , -R 1 0 -S-S-R 10 -C(R 8 )(N(R 8 )R 9 )C(O(OR 8 , -R 10 -SC(0)N(R 8 )R 9 , -R 1 0 -SC(S)N(R 8 )R 9 , -R 10 -S(O)R 8 , -R 1 0 -S(O) 2 R 1 1 , -R 1 0 -S(O)OR 8 , -R 1 0 -S(0) 2 OR 8 , -R 1 0 -S(O) 2 N(R 8 )R 9 , -R 1 0 -S(O)(NR 8 )R 9 ; or R 6 is aryl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -N(R 8 )R 9 , -C(0)OR 8 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -OP(0)(OR 8 ) 2 ); or R 6 is aralkyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -N(R 8 )R 9 , -C(0)OR 8 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -OP(O)(0R 8 ) 2 ) , or R 6 is heterocyclyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, aralkyl, -OR 8 , -C(0)OR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -OP(0)(OR 8 ) 2 ); or R 6 is heterocyclylalkyl (where the heterocyclyl radical is optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, aralkyl, -OR 8 , -SR 8 , -C(0)OR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 ), -S(0) 2 OR 8 and -OP(0)(OR 8 ) 2 ); or R 6 is adamantyl (optionally substituted by alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -C(0)OR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -OP(0)(OR 8 ) 2 ); or R 6 is adamantylalkyl (where the adamantyl radical is optionally substituted by alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -C(0)OR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 , -S(0) 2 0R 8 and -0P(O)(OR 8 ) 2 ); R 7 is hydrogen, alkyl, cycloalkyl, aralkyl or aryl; each R 8 and R 9 is independently hydrogen, alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl); R 10 is a straight or branched alkylene chain; and R 1 1 is alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl) , or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), as a single stereoisomer or a mixture thereof; or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient thereof 1 3. A method of treating a human having a disease-state characterized by thrombotic activity, which method comprises administering to a human in need thereof a therapeutically effective amount of a compound selected from the group consisting of the following formulae: a n d wherein: A is -0-, -N(R 5 )-, or -S(0) n - (where n is 0, 1 or 2); Z 1 and Z 2 are independently -0-, -N(R 5 )- or -OCH 2 -; R 1 and R 4 are each independently hydrogen, halo, alkyl, -OR 8 , -C(0)OR 8 , -C(0)N(R 8 )R 9 , -N(R 8 )R 9 , -N(R 8 )C(0)R 9 , or -N(H)S(0) 2 R 1 ' ; R 2 is -C(NH)NH 2 , -C(NH)N(H)OR 8 , -C(NH)N(H)C(0)OR 1 1 , -C(NH)N(H)C(0)R 8 , -C(NH)N(H)S(0) 2 R 1 1 , or -C(NH)N(H)C(0)N(H)R 8 ; R 3 is halo, alkyl, haloalkyl, haloalkoxy, cyano, ureido, guanidino, -OR 8 , -C(NH)NH 2 , -C(NH)N(H)OR 8 , -C(0)N(R 8 )R 9 , -R 10 -C(O)N(R 8 )R 9 , -CH(OH)C(0)N(R 8 )R 9 , -N(R 8 )R 9 , -R 10 -N(R 8 )R 9 , -C(0)OR 8 , -R 10 -C(0)OR 8 , -N(R 8 )C(0)R 8 , (1 ,2)-tetrahydropyrιmιdιnyl (optionally substituted by alkyl), (1 ,2)-ιmιdazolyl (optionally substituted by alkyl), or (1,2)-ιmιdazolιnyl (optionally substituted by alkyl); each R 5 is hydrogen, alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, am o, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl); R 6 is hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, cycloalkyl, cycloalkylalkyl, -C(0)OR 8 , -R 10 -C(O)OR 8 , -R 10 -C(0)N(R 8 )R 9 , -C(0)-R 10 -N(R 8 )R 9 , -R 10 -C(O)R 8 , -R 10 -C(0)N(R 8 )N(R 8 )R 9 , -R 10 -C(R 8 )(OR 9 )-R 10 -N(R 8 )(R 9 ), -C(R 8 )(OR 8 )C(0)OR 9 , -R 10 -C(R 8 )(C(O)OR 9 ) 2 , -C(R 8 )(N(R 8 )R 9 )C(0)OR 8 , -R 10 -C(R 8 )(N(R 8 )R 9 )C(O)OR 8 , -C(R 8 KOR 8 )R 9 , -R 10 -N(R 8 )R 9 , -R 10 -N(R 8 )C(O)OR 11 , -R 10 -N(R 8 )C(O)R 9 , -R 10 -N(R 8 )C(NR 8 )R 11 , -R 10 -N(R 8 )S(O) 2 R , -R 10 -N(R 8 )C(O)N(R 8 )R 9 , -R 10 -N(R 8 )C(NR 8 )N(R 8 )R 9 , -R 10 -N(R 8 )C(NR 8 )N(R 8 )N(R 8 )R 9 , -R 10 -N(R 8 )-R 10 -C(R 8 )(N(R 8 )R 9 )C(O)OR 8 , -R 10 -N(R 8 )S(0)R 9 , -R 10 OR 8 . -R 10 -ON(R 8 )C(NR 8 )IM(R 8 )R 9 , -R 10 -OS(0) 2 OR 8 , -R 10 -P(O)(OR 8 )R 9 , -R ,0 -OP(0)(OR 8 ) 2 , -R 10 -P(O)(OR 8 ) 2 , -R 10 -SR 8 , -R 10 -S-R 10 -C(O)OR 8 , -R 10 -S-R 10 -N(R 8 )R 9 , -R 10 -S-R 10 -C(R 8 )(N(R 8 )R 9 )C(O)OR 8 , -R 10 -S-R 10 -N(R 8 )C(O)OR 8 , -R 10 -S-R 10 -N(R 8 )C(O)R 8 , -R 10 -S-S-R 10 -C(R 8 HN(R 8 )R 9 )C(O>OR 8 , -R 10 -SC(O)N(R 8 )R 9 , -R 10 -SC(S)N(R 8 )R 9 , -R 10 -S(O)R 8 , -R 10 -S(0) 2 R 11 , -R 10 -S(O)OR 8 , -R 10 -S(O) 2 OR 8 , -R 10 -S(O) 2 N(R 8 )R 9 , -R 10 -S(O)(NR 8 )R 9 ; or R 6 is aryl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -N(R 8 )R 9 , -C(0)OR 8 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -OP(0)(OR 8 ) 2 ); or R 6 is aralkyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -N(R 8 )R 9 , -C(0)OR 8 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -OP(0)(OR 8 ) 2 ); or R 6 is heterocyclyl (optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, aralkyl, -OR 8 , -C(0)OR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -OP(0)(OR 8 ) 2 ); or R 6 is heterocyclylalkyl (where the heterocyclyl radical is optionally substituted by one or more substituents selected from the group consisting of alkyl, halo, haloalkyl, haloalkoxy, aralkyl, -OR 8 , -SR 8 , -C(0)OR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 ), -S(0) 2 OR 8 and -0P(0)(0R 8 ) 2 ); or R 6 is adamantyl (optionally substituted by alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -C(0)OR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -0P(0)(0R 8 ) 2 ); or R 6 is adamantylalkyl (where the adamantyl radical is optionally substituted by alkyl, halo, haloalkyl, haloalkoxy, -OR 8 , -SR 8 , -C(0)OR 8 , -N(R 8 )R 9 , -C(0)N(R 8 )R 9 , -S(0) 2 OR 8 and -OP(0)(OR 8 ) 2 ); R 7 is hydrogen, alkyl, cycloalkyl, aralkyl or aryl; each R 8 and R 9 is independently hydrogen, alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, am o, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl); R 0 is a straight or branched alkylene chain; and R 1 1 is alkyl, aryl (optionally substituted by halo, alkyl, hydroxy, alkoxy, aralkoxy, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl), or aralkyl (optionally substituted by halo, alkyl, aryl, hydroxy, alkoxy, aralkyl, ammo, dialkylamino, monoalkylamino, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl, or dialkylaminocarbonyl) ; as a single stereoisomer or a mixture thereof; or as a pharmaceutically acceptable salt thereof.

Inventors: BUCKMAN BRAD, MOHAN RAJU, MORRISSEY MICHAEL M, BUCKMAN, BRAD, MOHAN, RAJU, MORRISSEY, MICHAEL, M.
Applicants: SCHERING AG, SCHERING AKTIENGESELLSCHAFT
Application year: 1997
Main classification: C07D475
IPC codes: A61K31, A61P7, A61P43, C07D475, C07D498, C07D513