Fungicides

Abstract: Compounds, useful as plant fungicides, having the formula (I): or a stereoisomer thereof, wherein A is CH or N, B is OCH 3 or NHCH 3 , X is CH 2 , CH 2 O, O or S, Y is R 1 -C=C-R 2 or R 1 -CH-CH-R 2 wherein R 1 and R 2 are independently H, halo, hydroxy, alkyl, haloalkyl, alkoxy, haloalkoxy, cyano, nitro, amino, mono- or dialkylamino, alkanoylamino, carboxy, alkoxycarbonyl, aminocarbonyl, mono- or dialkylaminocarbonyl, alkylcarbonyloxy, optionally substituted aryl, optionally substituted aralkyl or optionally substituted aryloxy and Z is CH 2 , CHCH 3 , C(CH 3 ) 2 or C=O.

Description: The present invention relates to the novel compound methyl (E) -2-[2-(6-trifluoromethyl-3,4-dihydropyridin-2-yloxymethyl)phenyl]-3-methoxypropenoate, to processes for preparing it, to compositions containing it and to methods of using it to combat fungi, especially fungal infections of plants. Fungicidal compounds in which a nitrogen-containing heterocycle is linked through an oxymethylene or thiomethylene group to a phenyl ring containing an ortho methyl β-methoxyacrylate group are described in, for example, EP-A-0278595, EP-A-0299694, EP-A-0350691 and EP-A-0378308. Fungicidal compounds containing a methyl β-methoxyiminoacetate group and amide derivatives are described in, for example, EP-A-0363818 and EP-A-0398692. According to the present invention there is provided the compound methyl (E) -2-[2-(6-trifluoromethyl-3,4-dihydropyridin-2-yloxymethyl)phenyl]-3-methoxypropenoate having the formula (I): Table 1 shows selected proton NMR data obtained at 270MHz for the compound of formula (I). Chemical shifts are measured at 20°C in ppm from tetramethylsilane and deuterochloroform was used as solvent, unless otherwise stated. The following abbreviations are used: s = singlet t = triplet q = quartet m = multiplet br = broad ppm = parts per million Compound Melting Point °C Proton NMR Data (δ) ppm of formula (I) Oil 2.33(4H,m); 3.68(3H,s); 3.82(3H,s); 5.19(2H,brs); 5.98(1H,m); 7.1(4H,m); 7.55(1H,s). In general, the compound of formula (I) may be prepared by reacting a compound of formula (II) : with a compound of formula (III): wherein L is a leaving group such as halogen (chlorine, bromine or iodine) or OSO 2 CF 3 , with a suitable base such as silver carbonate in a suitable solvent such as toluene. Compounds of formula (III), particularly where L is bromo, are well documented in the literature and can be prepared by the methods described therein, see for example EP-A-0203606. The compound of formula (II), which is a dihydropyridone, may be prepared by cyclising acrylic anhydride and a compound of the formula H 2 N-C(CF 3 )=CH.COO.C 2 H 5 at a temperature of around 100°C. The ethyl 5-carboxy-3,4-dihydro-6-trifluoro-methylpyrid-2-one so obtained may be decarboxylated to provide a compound of the formula (II). Alternatively, the compound of formula (I) can be prepared from a phenylacetate of formula (IV) or a ketoester of formula (V) by the steps shown in Scheme 1. Throughout Scheme 1 R 5 is hydrogen or a metal such as sodium or potassium and R is an alkyl group. Each transformation is performed at a suitable temperature and usually, though not always, in a suitable solvent. Thus, the compound of formula (I) can be prepared by treatment of a phenylacetate of formula (IV) with a base, such as sodium hydride or sodium methoxide, and methyl formate. If a species of formula CH 3 L' , wherein L' is a leaving group such as halide (for example chlorine, bromine or iodine), or a CH 3 SO 4 anion, is then added to the reaction mixture, a compound of formula (I) is obtained. If a protic acid is added to the reaction mixture, a compound of formula (VI), wherein R 5 is hydrogen, is obtained. Alternatively, the compound of formula (VI) wherein R 5 is a metal such as sodium can be isolated from the reaction mixture. A compound of formula (VI) wherein R 5 is a metal can be converted into the compound of formula (I) by treatment with a species CH 3 L' , wherein L' is as defined above. A compound of formula (VI) wherein R 5 is hydrogen can be converted into the compound of formula (I) by successive treatment with a base, such as potassium carbonate, and a species of general formula CH 3 L'. Alternatively, the compound of formula (I) can be prepared from the acetal of formula (VII) by elimination of methanol under either acidic or basic conditions. Examples of reagents or reagent mixtures which can be used for this transformation are lithium diisopropylamide, potassium hydrogen sulphate (see, for example, T Yamada, H Hagiwara and H Uda, J.Chem.Soc.Chemical Communications , 1980, 838 and references therein, and triethylamine, often in the presence of a Lewis acid such as titanium tetrachloride (see, for example, K Nsunda and L Heresi, J.Chem.Soc.Chemical Communications, 1985, 1000). The acetals of formula (VII) can be prepared by treatment of a methyl silyl ketene acetal of formula (VIII) with trimethyl orthoformate in the presence of a Lewis acid such as titanium tetrachloride (see, for example, K Saigo, M Osaki and T Mukaiyama, Chemistry Letters, 1976, 769). A methyl silyl ketene acetal of formula (VIII) can be prepared by treating the phenylacetate of formula (IV) with a base and a trialkylsilyl halide of formula R 3 SiCl or R 3 SiBr, such as trimethylsilyl chloride, or a base, such as triethylamine, and a trialkylsilyl triflate of formula R 3 Si-OSO 2 CF 3 (see, for example, C Ainsworth, F Chen and Y Kuo, J.Organometallic Chemistry, 1972, 46, 59). It is not always necessary to isolate the intermediates (VII) and (VIII). Under appropriate conditions the compound of formula (I) can be prepared from the phenylacetate of formula (IV) in "one pot" by the successive addition of suitable reagents listed above. The phenylacetate of formula (IV) can be prepared from a phenylacetate of formula (IX). Thus, if the compound of formula (II) is treated with a suitable base such as silver carbonate and a phenyl acetate of formula (IX) added, the phenylacetate of formula (IV) is obtained. A phenylacetate of formula (IX) can be prepared by treating the isochromanone of formula (X) with HL, wherein L is preferably bromine, in methanol. This transformation can also be accomplished in 2 steps if the isochromanone of formula (X) is treated with HL in a non-alcoholic solvent, and the resulting phenylacetic acid is then esterified using standard procedures (see, for example, I Matsumoto and J Yoshizawa, Jpn. Kokai (Tokkyo Koho) 79138536, 27.10.1979, ChemAbs., 1980, 92, 180829h; and G M Lim,Y G Perron and R D Droghini, Res.Discl .., 1979, 188, 672, Chem.Abs., 1980, 92, 128526t). The isochromanone of formula (X) is well known in the chemical literature. Alternatively, the compound of formula (I) can be prepared by treatment of the ketoester of formula (V) with a methoxymethylenation reagent such as methoxymethylenetriphenylphosphorane (see, for example, EP-A-0044448). The ketoester of formula (V) can be prepared from a ketoester of formula (XI), by treatment with the compound of formula (II) as described above. Ketoesters of formula (XI) are described in EP-A-0331061. The compound of formula (I) is an active fungicide and may be used to control one or more of the following pathogens: Pyricularia oryzae on rice and wheat and other Pyricularia spp. on other hosts; Puccinia recondita, Puccinia striiformis and other rusts on wheat, Puccinia hordei, Puccinia striiformis and other rusts on barley, and rusts on other hosts e.g. turf, rye, coffee, pears, apples, peanuts, sugar beet, vegetables and ornamental plants; Erysiphe graminis (powdery mildew) on barley, wheat, rye and turf and other powdery mildews on various hosts such as Sphaerotheca macularis on hops, Sphaerotheca fuliginea on cucurbits (e.g. cucumber), Podosphaera leucotricha on apple and Uncinula necator on vines; Cochliobolus spp., Helminthosporium spp., Drechslera spp. ( Pyrenophora spp.), Rhynchosporium spp., Septoria spp. (including Mycosphaerella graminicola and Leptosphaeria nodorum ), Pseudocercosporella herpotrichoides and Gaeumannomyces graminis on cereals (e.g. wheat, barley, rye), turf and other hosts; Cercospora arachidicola and Cercosporidium personatum on peanuts and other Cercospora species on other hosts, for example, sugar beet, bananas, soya beans and rice; Botrytis cinerea (grey mould) on tomatoes, strawberries, vegetables, vines and other hosts and other Botrytis spp. on other hosts; Alternaria spp. on vegetables (e.g. cucumber), oil-seed rape, apples, tomatoes, cereals (e.g. wheat) and other hosts; Venturia spp. (including Venturia inaequalis (scab)) on apples, pears, stone fruit, tree nuts and other hosts; Cladosporium spp. on a range of hosts including cereals (e.g. wheat); Monilinia spp. on stone fruit, tree nuts and other hosts; Didymella spp. on tomatoes, turf, wheat and other hosts; Phoma spp. on oil-seed rape, turf, rice, potatoes, wheat and other hosts; Aspergillus spp. and Aureobasidium spp. on wheat, lumber and other hosts; Ascochyta spp. on peas, wheat, barley and other hosts; Plasmopara viticola on vines; other downy mildews such as Bremia lactucae on lettuce, Peronospora spp. on soybeans, tobacco, onions and other hosts, Pseudoperonospora humuli on hops and Pseudoperonospora cubensis on cucurbits; Pythium spp. (including Pythium ultimum ) on turf and other hosts; Phytophthora infestans on potatoes and tomatoes and other Phytophthora spp. on vegetables, strawberries, avocado, pepper, ornamentals, tobacco, cocoa and other hosts; Thanatephorus cucumeris on rice and turf and other Rhizoctonia species on various hosts such as wheat and barley, vegetables, cotton and turf; Sclerotinia spp. on turf, peanuts, oil-seed rape and other hosts; Sclerotium spp. on turf, peanuts and other hosts; Colletotrichum spp. on a range of hosts including turf, coffee and vegetables; Laetisaria fuciformis on turf; Mycosphaerella spp. on banana, peanut, citrus, pecan, papaya and other hosts; Diaporthe spp. on citrus, soybean, melon, pear, lupin and other hosts; Elsinoe spp. on citrus, vines, olives, pecans, roses and other hosts; Pyrenopeziza spp. on oil-seed rape and other hosts; Oncobasidium theobromae on cocoa causing vascular streak dieback; Fusarium spp., Typhula spp., Microdochium nivale, Ustilago spp., Urocystis spp., Tilletia spp., and Claviceps purpurea on a variety of hosts but particularly wheat, barley, turf and maize; Ramularia spp. on sugar beet and other hosts; post-harvest diseases particularly of fruit (e.g. Pencillium digitatum and P. italicum and Trichoderma viride on oranges, Colletotrichum musae and Gloeosporium musarum on bananas and Botrytis cinerea on grapes); other pathogens on vines, notably Eutypa lata , Guignardia bidwellii, Phellinus igniarus , Phomopsis viticola, Pseudopezicula tracheiphila and Stereum hirsutum ; other pathogens on lumber, notably Cephaloascus fragrans, Ceratocystis spp., Ophiostoma piceae , Penicillium spp., Trichoderma pseudokoningii, Trichoderma viride, Trichoderma harzianum, Aspergillus niger, Leptographium lindbergi and Aureobasidium pullulans ; and fungal vectors of viral diseases e.g. Polymyxa graminis on cereals as the vector of barley yellow mosaic virus (BYMV). Further, the compound may be useful as a seed dressing against pathogens including Fusarium spp., Septoria spp., Tilletia spp., (e.g. bunt, a seed-borne disease of wheat), Ustilago spp. and Helminthosporium spp. on cereals, Rhizoctonia solani on cotton and Pyricularia oryzae on rice. In particular, the compound may show good eradicant activity against Plasmopara viticola and Pythium ultimum. The compound may move acropetally/locally in plant tissue. Moreover, the compound may be volatile enough to be active in the vapour phase against fungi on the plant. The invention therefore provides a method of combating fungi which comprises applying to a plant, to a seed of a plant or to the locus of the plant or seed a fungicidally effective amount of the compound of formula (I) or a composition containing the same. The compound may be used directly for agricultural purposes but is more conveniently formulated into compositions using a carrier or diluent. The invention thus provides fungicidal compositions comprising the compound of formula (I) and an acceptable carrier or diluent therefor. It is preferred that all compositions, both solid and liquid formulations, comprise 0.0001 to 95%, more preferably 1 to 85%, for example 1 to 25% or 25 to 60%, of the compound of formula (I). When applied to the foliage of plants, the compound of the invention is applied at rates of 0.1g to 10kg, preferably 1g to 8kg, more preferably 10g to 4kg, of active ingredient (invention compound) per hectare. When used as seed dressings, the compound of the invention is used at rates of 0.0001g (for example 0.001g or 0.05g) to 10g, preferably 0.005g to 8g, more preferably 0.005g to 4g, of active ingredient (invention compound) per kilogram of seed. The compound can be applied in a number of ways. For example, it can be applied, formulated or unformulated, directly to the foliage of a plant, to seeds or to other medium in which plants are growing or are to be planted, or it can be sprayed on, dusted on or applied as a cream or paste formulation, or it can be applied as a vapour or as slow release granules. Application can be to any part of the plant including the foliage, stems, branches or roots, or to soil surrounding the roots, or to the seed before it is planted, or to the soil generally, to paddy water or to hydroponic culture systems. The invention compound may also be injected into plants or sprayed onto vegetation using electrodynamic spraying techniques or other low volume methods, or applied by land or aerial irrigation systems. The term "plant" as used herein includes seedlings, bushes and trees. Furthermore, the fungicidal method of the invention includes preventative, protectant, prophylactic, systemic and eradicant treatments. The compound is preferably used for agricultural and horticultural purposes in the form of a composition. The type of composition used in any instance will depend upon the particular purpose envisaged. The compositions may be in the form of dustable powders or granules comprising the active ingredient (invention compound) and a solid diluent or carrier, for example, fillers such as kaolin, bentonite, kieselguhr, dolomite, calcium carbonate, talc, powdered magnesia, fuller's earth, gypsum, diatomaceous earth and china clay. Such granules can be preformed granules suitable for application to the soil without further treatment. These granules can be made either by impregnating pellets of filler with the active ingredient or by pelleting a mixture of the active ingredient and powdered filler. Compositions for dressing seed may include an agent (for example, a mineral oil) for assisting the adhesion of the composition to the seed; alternatively the active ingredient can be formulated for seed dressing purposes using an organic solvent (for example, N -methylpyrrolidone, propylene glycol or N , N -dimethylformamide). The compositions may also be in the form of water dispersible powders or water dispersible granules comprising wetting or dispersing agents to facilitate the dispersion in liquids. The powders and granules may also contain fillers and suspending agents. The compositions may also be in the form of soluble powders or granules, or in the form of solutions in polar solvents. Soluble powders may be prepared by mixing the active ingredient with a water-soluble salt such as sodium bicarbonate, sodium carbonate, magnesium sulphate or a polysaccharide, and a wetting or dispersing agent to improve water dispersibility/solubility. The mixture may then be ground to a fine powder. Similar compositions may also be granulated to form water-soluble granules. Solutions may be prepared by dissolving the active ingredient in polar solvents such as ketones, alcohols and glycol ethers. These solutions may contain surface active agents to improve water dilution and prevent crystallisation in a spray tank. Emulsifiable concentrates or emulsions may be prepared by dissolving the active ingredient in an organic solvent optionally containing a wetting or emulsifying agent and then adding the mixture to water which may also contain a wetting or emulsifying agent. Suitable organic solvents are aromatic solvents such as alkylbenzenes and alkylnaphthalenes, ketones such as cyclohexanone and methylcyclohexanone, chlorinated hydrocarbons such as chlorobenzene and trichlorethane, and alcohols such as benzyl alcohol, furfuryl alcohol, butanol and glycol ethers. Aqueous suspension concentrates of largely insoluble solids may be prepared by ball or bead milling with a dispersing agent with a suspending agent included to stop the solid settling. Compositions to be used as sprays may be in the form of aerosols wherein the formulation is held in a container under pressure of a propellant, e.g. fluorotrichloromethane or dichlorodifluoromethane. The invention compound can be mixed in the dry state with a pyrotechnic mixture to form a composition suitable for generating in enclosed spaces a smoke containing the compounds. Alternatively, the compound may be used in micro-encapsulated form. It may also be formulated in biodegradable polymeric formulations to obtain a slow, controlled release of the active substance. By including suitable additives, for example additives for improving the uptake, distribution, adhesive power and resistance to rain on treated surfaces, the different compositions can be better adapted for various utilities. Other additives may be included to improve the biological efficacy of the various formulations. Such additives can be surface active materials to improve the wetting and retention on surfaces treated with the formulation and also the uptake and mobility of the active material, or additionally can include oil based spray additives, for example, certain mineral oil and natural plant oil (such as soya bean and rape seed oil) additives, or blends of them with other adjuvants. The invention compound can be used as a mixture with fertilisers (e.g. nitrogen-, potassium- or phosphorus-containing fertilisers). Compositions comprising only granules of fertiliser incorporating, for example coated with, the compound of formula (I) are preferred. Such granules suitably contain up to 25% by weight of the compound. The invention therefore also provides a fertiliser composition comprising a fertiliser and the compound of formula (I). Water dispersible powders, emulsifiable concentrates and suspension concentrates will normally contain surfactants, e.g. a wetting agent, dispersing agent, emulsifying agent or suspending agent. These agents can be cationic, anionic or non-ionic agents. Suitable cationic agents are quaternary ammonium compounds, for example, cetyltrimethylammonium bromide. Suitable anionic agents are soaps, salts of aliphatic monoesters of sulphuric acid (for example, sodium lauryl sulphate), and salts of sulphonated aromatic compounds (for example, sodium dodecylbenzenesulphonate, sodium, calcium or ammonium lignosulphonate, butylnaphthalene sulphonate, and a mixture of sodium diisopropyl- and triisopropylnaphthalene sulphonates). Suitable non-ionic agents are the condensation products of ethylene oxide with fatty alcohols such as oleyl or cetyl alcohol, or with alkyl phenols such as octyl- or nonylphenol and octylcresol. Other non-ionic agents are the partial esters derived from long chain fatty acids and hexitol anhydrides, alkyl glucosides, polysaccharides and the lecithins and the condensation products of the said partial esters with ethylene oxide. Suitable suspending agents are hydrophilic colloids (for example, polyvinylpyrrolidone and sodium carboxymethylcellulose), and swelling clays such as bentonite or attapulgite. Compositions for use as aqueous dispersions or emulsions are generally supplied in the form of a concentrate containing a high proportion of the active ingredient, the concentrate being diluted with water before use. These concentrates should preferably be able to withstand storage for prolonged periods and after such storage be capable of dilution with water in order to form aqueous preparations which remain homogeneous for a sufficient time to enable them to be applied by conventional spray equipment. The concentrates may conveniently contain up to 95%, suitably 1-85%, for example 1-25% or 25-60%, by weight of the active ingredient. After dilution to form aqueous preparations, such preparations may contain varying amounts of the active ingredient depending upon the intended purpose, but an aqueous preparation containing 0.0001 to 10%, for example 0.005 to 10%, by weight of active ingredient may be used. The compositions of this invention may contain other compounds having biological activity, e.g. compounds having similar or complementary fungicidal activity or which possess plant growth regulating, herbicidal or insecticidal activity. By including another fungicide, the resulting composition can have a broader spectrum of activity or a greater level of intrinsic activity than the compound of formula (I) alone. Further the other fungicide can have a synergistic effect on the fungicidal activity of the compound of formula (I). Examples of fungicidal compounds which may be included in the composition of the invention are ( E )- N -methyl-2-(2-phenoxyphenyl)-2-methoxyiminoacetamide, ( E )- N -methyl-2-[2-(2,5-dimethylphenoxymethyl)phenyl]-2-methoxyiminoacetamide, ( RS )-1-aminopropylphosphonic acid, ( RS )-4-(4-chlorophenyl)-2-phenyl-2-(1 H -1,2,4-triazol-1-ylmethyl)butyronitrile, Z )- N -but-2-enyloxymethyl-2-chloro-2',6'-diethylacetanilide, 1-(2-cyano-2-methoxyiminoacetyl)-3-ethylurea, 4-(2,2-difluoro-1,3-benzodioxol-4-yl)pyrrole-3-carbonitrile, 4-bromo-2-cyano- N , N -dimethyl-6-trifluoromethylbenzimidazole-1-sulphonamide, 5-ethyl-5,8-dihydro-8-oxo(1,3)-dioxol-(4,5-g)quinoline-7-carboxylic acid, α-[ N -(3-chloro-2,6-xylyl)-2-methoxyacetamido]-γ-butyrolactone, N -(2-methoxy-5-pyridyl)-cyclopropane carboxamide, alanycarb, aldimorph, ampropylfos, anilazine, azaconazole, azafenidin, azoxystrobin, benalaxyl, benomyl, biloxazol, binapacryl, bitertanol, blasticidin S, bromuconazole, bupirimate, butenachlor, buthiobate, captafol, captan, carbendazim, carbendazim chlorhydrate, carboxin, carvone, chinomethionate, chlorbenzthiazone, chloroneb, chlorothalonil, chlorozolinate, clozylacon, copper containing compounds such as copper oxychloride, copper oxyquinolate, copper sulphate, copper tallate, and Bordeaux mixture, cycloheximide, cymoxanil, cyproconazole, cyprofuram, debacarb, di-2-pyridyl disulphide 1,1'-dioxide, dichlofluanid, dichlone, diclobutrazol, diclomezine, dicloran, didecyl dimethyl ammonium chloride, diethofencarb, difenoconazole, difenzoquat, diflumetorim, O , O -di- iso -propyl-S-benzyl thiophosphate, dimefluazole, dimetconazole, dimethomorph, dimethirimol, diniconazole, dinocap, dipyrithione, ditalimfos, dithianon, dodemorph, dodine, doguadine, edifenphos, epoxiconazole, etaconazole, ethirimol, ethoxyquin, ethyl ( Z ) -N -benzyl -N- ([methyl(methylthioethylideneamino-oxycarbonyl)amino]thio)-β-alaninate, etridiazole, famoxadone, fenaminosulph, fenapanil, fenarimol, fenbuconazole, fenfuram, fenpiclonil, fenpropidin, fenpropimorph, fentin acetate, fentin hydroxide, ferbam, ferimzone, fluazinam, fludioxonil, flumetover, fluoroimide, fluquinconazole, flusilazole, flutolanil, flutriafol, folpet, fuberidazole, furalaxyl, furametpyr, furconazole-cis, guazatine, hexaconazole, hydroxyisoxazole, hymexazole, ICIA5504, imazalil, imibenconazole, ipconazole, iprobenfos, iprodione, isopropanyl butyl carbamate, isoprothiolane, kasugamycin, kresoxim-methyl, mancozeb, maneb, mefenoxam, mepanipyrim, mepronil, metalaxyl, metconazole, methfuroxam, metiram, metiram-zinc, metsulfovax, myclobutanil, NTN0301, neoasozin, nickel dimethyldithiocarbamate, nitrothal-isopropyl, nuarimol, ofurace, organomercury compounds, oxadixyl, oxasulfuron, oxolinic acid, oxycarboxin, pefurazoate, penconazole, pencycuron, phenazin oxide, phosetyl-Al, phosphorus acids, phthalide, polyoxin D, polyram, probenazole, prochloraz, procymidone, propamocarb, propamocarb hydrochloride, propiconazole, propineb, propionic acid, prothiocarb, pyracarbolid, pyrazophos, pyrifenox, pyrimethanil, pyroquilon, pyroxyfur, pyrrolnitrin, quaternary ammonium compounds, quinconazole, quinomethionate, quinoxyfen, quintozene, rabenazole, sodium pentachlorophenate, spiroxamine, streptomycin, sulphur, tebuconazole, techlofthalam, tecnazene, tetraconazole, thiabendazole, thicyofen, thifluzamide, 2-(thiocyanomethylthio)benzothiazole, thiophanatemethyl, thiram, timibenconazole, tolclofos-methyl, tolylfluanid, triacetate salt of 1,1'-iminodi(octamethylene)diguanidine, triadimefon, triadimenol, triazbutyl, triazoxide, tricyclazole, tridemorph, triforine, triflumizole, triticonazole, validamycin A, vapam, vinclozolin, XRD-563, zineb and ziram. The compound of formula (I) can be mixed with soil, peat or other rooting media for the protection of plants against seed-borne, soil-borne or foliar fungal diseases. The following Examples illustrate the invention. Throughout the Examples, the term 'ether' refers to diethyl ether, magnesium sulphate was used to dry solutions except where otherwise indicated, and solutions were concentrated under reduced pressure. All reactions were performed under an atmosphere of nitrogen and solvents were dried before use, where appropriate. Unless otherwise stated, chromatography was performed on a column of silica gel as the stationary phase. The following abbreviations are used throughout: ppm = parts per million mp = melting point DMSO = dimethyl sulphoxide Abbreviations for NMR data are as indicated in Table 1. Example 1 This Example illustrates the preparation of methyl ( E )-2-[2-(6-trifluoromethyl-3,4-dihydropyridin-2-yloxymethyl)phenyl]-3-methoxypropenoate. A mixture of acrylic anhydride (1.3g) and ethyl 3-amino-4,4,4-trifluoromethylcrotonate (1.8g) were heated to 100°C for 5 hours. On cooling the product crystallised from the reaction mixture and was isolated by trituration with ether to give ethyl 5-carboxy-3,4-dihydro-6-trifluoromethyl-pyrid-2-one (1.1g, 47% yield) as white solid mp 118-9°C; 1 H NMR (270Mz): 1.4(3H,t), 2.6(2H,t), 2.8(2H,m), 4.25(2H,q), 7.5(1H,brs) ppm. Ethyl 5-carboxy-3,4-dihydro-6-trifluoromethyl-pyrid-2-one (5.5g) and lithium chloride (1.3g) was heated in DMSO (25ml) at 180°C (bath temperature) for 16 hours. After cooling the reaction mixture was poured into brine and extracted into ethyl acetate. The combined extracts were washed with water, dried and concentrated to give 3,4-dihydro-6-trifluoromethyl-pyrid-2-one (2.2g, 57% yield) as a white solid mp 101-3°C; 1H NMR (270Mz): 2.5(4H,m), 5.75(1H,m), 7.5(1H,brs) ppm. 3,4-Dihydro-6-trifluoromethyl-pyrid-2-one (1.1g), ( E )-methyl 2-[2-(bromomethyl)-phenyl]-3-methoxypropenoate (1.1g) and silver carbonate (1.0g) were heated to reflux in toluene (150ml) for 5 hours. After cooling the mixture was filtered through Hyflo Supercel. The Supercel was washed with ethyl acetate. The combined organic extracts were washed with brine, dried, concentrated and chromatographed using ether:hexane 3:2. This gave the title compound (132mg) a clear gum; 1 H NMR given in Table 1. Example 2 The compound was tested against a variety of foliar fungal diseases of plants. The technique employed was as follows. The plants were grown in John Innes Potting Compost (No 1 or 2) in 4 cm diameter minipots. The test compounds were formulated either by bead milling with aqueous Dispersol T or as a solution in acetone or acetone/ethanol which was diluted to the required concentration immediately before use. The formulations (100 ppm active ingredient) were sprayed on to the foliage or applied to the roots of the plants in the soil. The sprays were applied to maximum retention and the root drenches to a final concentration equivalent to approximately 40 ppm a.i. in dry soil. Tween 20 was added to give a final concentration of 0.05% when the sprays were applied to cereals. For most of the tests the compounds were applied to the soil (roots) or to the foliage (by spraying) one or two days before the plant was inoculated with the disease. Exceptions were the tests on Erysiphe graminis and Puccinia recondita in which the plants were inoculated 24 hours and 48 hours, respectively, before treatment. Foliar pathogens were applied by spray as zoosporangial suspensions onto the leaves of test plants. After inoculation, the plants were put into an appropriate environment to allow infection to proceed and then incubated until the disease was ready for assessment. The period between inoculation and assessment varied from four to fourteen days according to the disease and environment. The disease level present (i.e. leaf area covered by actively sporulating disease) on each of the treated plants was recorded using the following assessment scale: 0 = 0% disease present 20 = 10.1-20% disease present 1 = 0.1-1% disease present 30 = 20.1-30% disease present 3 = 1.1-3% disease present 60 = 30.1-60% disease present 5 = 3.1-5% disease present 90 = 60.1-100% disease present 10 = 5.1-10% disease present Each assessment was then expressed as a percentage of the level of disease present on the untreated control plants. This calculated value is referred to as a POCO (Percentage of Control) value. An example of a typical calculation is as follows: Disease level on untreated control = 90 Disese level on treated plant = 30 POCO = disease level on treated plant disease level on untreated control x 100 = 30 90 x 100 = 33.3 This calculated POCO value is then rounded to the nearest of the values in the 9-point assessment scale shown above. In this particular example, the POCO value would be rounded to 30. If the calculated POCO falls exactly mid-way between two of the points, it is rounded to the lower of the two values. The results are shown in Table 2. Compound ERYSGT LEPTNO PUCCRT PLASVI PHYTIN VENTIN of formula (I) 0 0 0 0 0 0 Unless stated otherwise, data represent activity following application as a combined foliar spray and root drench treatment at 100 ppm. Key to Diseases ERYSGT Erysiphe graminis tritici PLASVI Plasmopara viticola LEPTNO Septoria nodorum PHYTIN Phytophthora infestans lycopersici PUCCRT Puccinia recondita VENTIN Venturia inaequalis

Claims: The compound methyl (E) -2-[2-(6-trifluoromethyl-3,4-dihydropyridin-2-yloxymethyl)phenyl]-3-methoxypropenoate having the formula (I): A process for preparing the compound according to claim 1 which comprises reacting the compound of formula (II): with a compound of formula (III): wherein L is a leaving group, in the presence of a base. A fungicidal composition comprising a fungicidally effective amount of the compound according to claim 1 and a fungicidally acceptable carrier or diluent therefor. A method of combating fungi which comprises applying to plants, to the seeds of plants or to the locus of the plants or seeds, the compound according to claim 1 or a composition according to claim 3.

Inventors: CROWLEY PATRICK JELF, DE FRAINE PAUL JOHN, MATTHEWS IAN RICHARD, WILLIAMS JOHN, CROWLEY, PATRICK JELF, DE FRAINE,PAUL JOHN, MATTHEWS, IAN RICHARD, WILLIAMS, JOHN
Applicants: SYNGENTA LTD, SYNGENTA LIMITED
Application year: 1996
Main classification: C07D211
IPC codes: A01N43