SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES FOR USE IN VETERINARY THERAPIES AS ANTIINFLAMMATORY AGENTS

Abstract: A method of using pyrazolyl benzenesulfonamide compounds in treating inflammation and inflammation-related disorders in animals.

Description: SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES FOR USE IN VETERINARY THERAPIES AS ANTIINFLAMMATORY AGENTS FIELD OF THE INVENTION 5 This invention is in the field of methods for treating inflammation and inflammation-associated disorders, such as arthritis, in animals. 10 BACKGROUND OF THE INVENTION There are few drugs that can be successfully used in veterinary medicine for the treatment of inflammation [Compendium of Veterinary Products, (K. Bennett 2d ed. 15 1993)] . See also The Merck Veterinary Manual, 1504-1509 (7th ed. 1991) . Prostaglandins play a major role in the inflammation process and the inhibition of prostaglandin production, especially production of PGG2, PGH2 and PGE2, has been a 20 common target of anti-inflammatory drug discovery. However, common non-steroidal anti-inflammatory drugs (NSAIDs) that are active in reducing the prostaglandin-induced pain and swelling associated with the inflammation process are also active in affecting other prostaglandin-regulated processes 25 not associated with the inflammation process. Thus, use of high doses of most common NSAIDs can produce severe side effects, including life threatening ulcers, that limit their therapeutic potential [C. MacAllister et al., JAVMA, 202, 71 (1993) . An alternative to NSAIDs is the use of 30 corticosteroids, which have even more drastic side effects, especially when long term therapy is involved [R. McDonald and V. Langston, Use of Corticosteroids and Non-steroidal Anti -inflammatory Agents, in Textbook of Veterinary Internal Medicine, 284 (Ettinger and Feldman 4th ed. 35 1995)]. Carprofen has been described for the treatment of osteoarthritis in dogs [P. Vasseur et al. , JAVMA, 206, 807 (1995)] . Piroxicam has been used in treatment of dogs with carcinomas [D. Knapp et al., J. of Vet . Int . Med. , 8, 273 (1994)] . Previous NSAIDs have been found to prevent the production of prostaglandins by inhibiting enzymes in the human arachidonic acid/prostaglandin pathway, including the enzyme cyclooxygenase (COX) [S. Rubin and M. Papich, Nonsteroidal Anti -inflammatory Drugs, in Current Veterinary Therapy, X, 47-54 (1989)]. The recent discovery of an inducible enzyme associated with inflammation (named "cyclooxygenase II (COX II) " or "prostaglandin G/H synthase II") provides a viable target of inhibition which more effectively reduces inflammation and produces fewer and less drastic side effects. Pyrazoles have been described for use in the treatment of inflammation. U.S. Patent No. 5,134,142 to Matsuo et al describes 1,5-diaryl pyrazoles, and specifically, l-(4- fluorophenyl) -5-[4-(methylsulfonyl)phenyl]-3- trifluoromethyl pyrazole, as having anti-inflammatory activity. U.S. Patent No. 3,940,418 to R. Hamilton describes tricyclic 4, 5-dihydrobenz[g]indazoles as antiinflammatory agents. In addition, R. Hamilton [J. Heterocyclic Chem . , 13, 545 (1976)] describes tricyclic 4,5-dihydrobenz[g]indazoles as antiinflammatory agents. U.S. Patent No. 5,134,155 describes fused tricyclic pyrazoles having a saturated ring bridging the pyrazole and a phenyl radical as HMG-CoA reductase inhibitors. European publication EP 477,049, published Mar. 25, 1992, describes [4,5- dihydro-l-phenyl-lH-benz[g]indazol-3-yl]amides as having antipsychotic activity. European publication EP 347,773, published Dec. 27, 1989, describes [4,5- dihydro-1-phenyl-lH-benz[g]indazol-3-yl]propanamides as immunostimulants. M. Hashem et al [ J. Med . Chem . , 19, 229 (1976)] describes fused tricyclic pyrazoles, having a saturated ring bridging the pyrazole and a phenyl radical, as antibiotics. Certain substituted pyrazolyl-benzenesulfonamides have been described in the literature as synthetic intermediates. Specifically, 4-[5- (4-chlorophenyl) -3- phenyl-lH-pyrazol-l-yl]benzenesulfonamide has been prepared from a pyrazoline compound as an intermediate for compounds having hypoglycemic activity [R. Soliman et al, J. Pharm . Sci . , 76, 626 (1987)]. 4-[5-[2- (4-Bromophenyl) -2H-1 , 2,3- triazol-4-yl]-3-methyl-lH-pyrazol-l-yl]benzenesulfonamide has been prepared from a pyrazoline compound and described as potentially having hypoglycemic activity [H. Mokhtar, Pak. J. Sci . Ind. Res . , 31, 762 (1988)]. Similarly, 4-[4- bromo-5-[2- (4-chlorophenyl) -2H-1 , 2 ,3-triazol-4-yl] -3- methyl-lH-pyrazol-l-yl]benzenesulfonamide has been prepared [H. Mokhtar et al, Pak. J. Sci . Ind. Res . , 34, 9 (1991)]. The phytotoxicity of pyrazole derivatives is described [M. Cocco et al, II . Farmaco-Ed. Sci . , 40, 272 (1985)], specifically for 1-[4- (aminosulfonyl)phenyl] -5-phenyI-lH- pyrazole-3,4-dicarboxylic acid. The use of styryl pyrazole esters for antidiabetes drugs is described [H. Mokhtar et al, Pharmazie, 33, 649- 651 (1978) ] . The use of styryl pyrazole carboxylic acids for antidiabetes drugs is described [R. Soliman et al, Pharmazie, 33, 184-5 (1978)]. The use of 4-[3,4,5- trisubstituted-pyrazol-l-yl]benzenesulfonamides as intermediates for sulfonylurea anti-diabetes agents is described, and specifically, 1-[4- (aminosulfonyl)phenyl]-3- methyl-5-phenyl-lH-pyrazole-4-carboxylic acid [R. Soliman et al, J. Pharm . Sci . , 72, 1004 (1983)]. A series of 4-[3- substituted methyl-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamides has been prepared as intermediates for anti-diabetes agents, and more specifically, 4-[3- methyl-5-phenyl-lH-pyrazol-l-yl]benzenesulfonamide [H. Feid-Allah, Pharmazie, 36, 754 (1981)]. In addition, l-(4- [aminosulfonyl]phenyl)-5-phenylpyrazole-3-carboxylic acid has been prepared from the above described 4-[3-methyl-5- phenyl-lH-pyrazol-l-yl]benzenesulfonamide compound [R. Soliman et al, J. Pharm . Sci . , 70, 602 (1981)]. However, pyrazolyl benzenesulfonamide compounds have not been previously described as veterinary agents. DESCRIPTION OF THE INVENTION A class of compounds useful in treating veterinary inflammation-related disorders is defined by Formula I: wherein R1 is selected from aryl and heteroaryl, wherein R-*- is substituted at a substitutable position with one or more radicals selected from sulfamyl, halo, alkyl, alkoxy, hydroxyl, haloalkyl and wherein R^ is selected from hydrido, halo, alkyl, haloalkyl, cyano, nitro, formyl, carboxyl, alkoxy, aminocarbonyl, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, amidino, cyanoamidino, cyanoalkyl, alkoxycarbonylcyanoalkenyl, aminocarbonylalkyl, N- alkylaminocarbonyl, N-arylaminocarbonyl, N,N- dialkylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, cycloalkylaminocarbonyl, heterocyclicaminocarbonyl, carboxyalkylaminocarbonyl, aralkoxycarbonylalkylaminocarbonyl, alkylcarbonyl, alkylcarbonylalkyl, hydroxyalkyl, haloaralkyl, carboxyhaloalky1, alkoxycarbonylhaloalkyl, aminocarbonylhaloalkyl, alkylaminocarbonylhaloalkyl, N- alkylamino, N,N-dialkylamino, N-arylamino, N- aralkylamino, N-alkyl-N-aralkylamino, N-alkyl-N- arylamino, aminoalkyl, N-alkylaminoalkyl, N,N- dialkylaminoalkyl, N-arylaminoalkyl, N- aralkylaminoalkyl, N-alkyl-N-aralkylaminoalkyl, N-alkyl- N-arylaminoalkyl, aryloxy, aralkoxy, arylthio, aralkylthio, alkylthio, alkylsulfinyl, alkylsulfonyl, N- alkylaminosulfonyl, N-arylaminosulfonyl, arylsulfonyl, N,N-dialkylaminosulfonyl, N-alkyl-N-arylaminosulfonyl, heterocyclic, R 7 R 7 R 7 ^γ^, s ^.N ^NH 2 t ^^ CH 3 , s 0 wherein R^ is selected from hydrido, alkyl, halo, haloalkyl, cyano, nitro, formyl, carboxyl, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, amidino, cyanoamidino, aminocarbonyl, alkoxy, N- alkylamino, N,N-dialkylamino, aminocarbonylalkyl, N- alkylaminocarbonyl, N-arylaminocarbonyl, N,N- dialkyla inocarbonyl, N-alkyl-N-arylaminocarbonyl, alkylcarbonyl, alkylcarbonylalkyl, hydroxyalkyl, alkylthio, alkylsulfinyl, alkylsulfonyl, N- alkylaminosulfonyl, N-arylaminosulfonyl, arylsulfonyl, N,N-dialkylaminosulfonyl, N-alkyl-N-arylaminosulfonyl, cycloalkyl, heterocyclic, heterocyclicalkyl and aralkyl; wherein R^ is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R^ is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkyl, alkenyl, alkylsulfonyl, cyano, carboxyl, alkoxycarbonyl, aminocarbonyl, N- alkylaminocarbonyl, N-arylaminocarbonyl, N,N- dialkylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, haloalkoxy, sulfamyl, N-alkylaminosulfonyl, amino, N-alkylamino, N,N-dialkylamino, heterocyclic, cycloalkylalkyl, nitro, acylamino, R 7 R 7 N γ^ , and / ^Υ^ 0 S or wherein R^ and R 4 together form wherein m is 1 to 3, inclusive; wherein A is selected from phenyl and five or six membered heteroaryl; wherein R 5 is alkyl; wherein R^ is one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkylsulfonyl, cyano, carboxyl, alkoxycarbonyl, aminocarbonyl, N- alkylaminocarbonyl, N-arylaminocarbonyl, alkyl, alkenyl, N,N-dialkylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, haloalkyl, hydrido, hydroxyl, alkoxy, hydroxyalkyl, haloalkoxy, sulfamyl, N-alkylaminosulfonyl, amino, N- alkylamino, N,N-dialkylamino, heterocyclic, cycloalkylalkyl, nitro and acylamino; and wherein R 7 is selected from hydrido, alkyl, aryl and aralkyl; or a pharmaceutically-acceptable salt thereof. Compounds of Formula I would be useful for, but not limited to, the treatment of inflammation in an animal, and for treatment of other inflammation- associated disorders, such as, as an analgesic in the treatment of pain, or as an antipyretic for the treatment of fever. For example, compounds of Formula I would be useful to treat inflammation of the musculoskeletal system, including chronic inflammation of hard and soft tissue, joint disease and traumatic injury. Compounds of Formula I would be useful to treat arthritis, including but not limited to rheumatoid arthritis, gouty arthritis, and osteoarthritis, myositis, and tendinitis. Such compounds of Formula I would be useful in the treatment of equine colic, mastitis, peritonitis, and skin related conditions such as burns and dermatitis. Compounds of Formula I also would be useful to treat gastrointestinal conditions such as gastritis, and ulcerative colitis, viral and bacterial infections of the Gl tract, and for the prevention of cancers, including colorectal cancer. Compounds of Formula I would be useful in treating inflammation in such diseases as vascular diseases, gingivitis, hypersensitivity, conjunctivitis and other eye inflammation, swelling occurring after injury or surgery, myocardial ischemia, and the like. The compounds are useful as antiinflammatory agents, such as for the treatment of arthritis, with the additional benefit of having significantly less harmful side effects. These compounds are useful for treatment of companion animals, exotic animals and farm animals, including mammals, rodents, avians, and the like. More preferred animals include horses, dogs, and cats. The present invention preferably includes compounds which selectively inhibit cyclooxygenase II over cyclooxygenase I. Preferably, the compounds have a cyclooxygenase II IC 50 of less than about 0.2 μM, and also have a selectivity ratio of cyclooxygenase II inhibition over cyclooxygenase I inhibition of at least 50, and more preferably of at least 100. Even more preferably, the compounds have a cyclooxygenase I IC 50 of greater than about 1 μM, and more preferably of greater than 10 μM. Such preferred selectivity may indicate an ability to reduce the incidence of common NSAID-induced side effects. A preferred class of compounds consists of those compounds of Formula I wherein R--- is selected -from aryl selected from phenyl, naphthyl and biphenyl, and five- or six-membered heteroaryl, wherein R 1 is substituted at a substitutable position with one or more radicals selected from sulfamyl, halo, lower alkyl, lower alkoxy, hydroxyl, lower haloalkyl and wherein R 2 is selected from hydrido, halo, lower alkyl, lower haloalkyl, cyano, nitro, formyl, carboxyl, lower alkoxycarbonyl, lower carboxyalkyl, lower alkoxycarbonylalkyl, amidino, cyanoamidino, lower cyanoalkyl, lower alkoxycarbonylcyanoalkenyl, aminocarbonyl, lower alkoxy, lower aryloxy, lower aralkoxy, lower aminocarbonylalkyl, lower N- alkylaminocarbonyl, N-arylaminocarbonyl, lower N,N- dialkylaminocarbonyl, lower N-alkyl-N-arylaminocarbonyl, lower cycloalkylaminocarbonyl, lower heterocyclicaminocarbonyl, lower carboxyalkylaminocarbonyl, lower aralkoxycarbonylalkylaminocarbonyl, lower haloaralkyl, lower carboxyhaloalkyl, lower alkoxycarbonylhaloalkyl, lower aminocarbonylhaloalkyl, lower alkylaminocarbonylhaloalkyl, lower alkylcarbonyl, lower alkylcarbonylalkyl, lower alkylamino, lower N,N- dialkylamino, N-arylamino, lower N-aralkylamino, lower N-alkyl-N-aralkylamino, lower N-alkyl-N-arylamino, lower aminoalkyl, lower N-alkylaminoalkyl, lower N,N- dialkylaminoalkyl, lower N-arylaminoalkyl, lower N- aralkylaminoalkyl, lower N-alkyl-N-aralkylaminoalkyl, lower N-alkyl-N-arylaminoalkyl, arylthio, lower aralkylthio, lower hydroxyalkyl, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower N- alkylaminosulfonyl, N-arylaminosulfonyl, arylsulfonyl, lower N,N-dialkylaminosulfonyl, lower N-alkyl-N- arylaminosulfonyl, heterocyclic, wherein R3 is selected from hydrido, lower alkyl, halo, lower haloalkyl, cyano, nitro, formyl, carboxyl, lower alkoxycarbonyl, lower carboxyalkyl, lower alkoxycarbonylalkyl, amidino, cyanoamidino, aminocarbonyl, lower alkoxy, lower N-alkylamino, lower N,N-dialkylamino, lower aminocarbonylalkyl, lower N- aIkylaminocarbonyl, lower N-arylaminocarbonyl, lower N,N-dialkylaminocarbonyl, lower N-alkyl-N- arylaminocarbonyl, lower alkylcarbonyl, lower alkylcarbonylalkyl, lower hydroxyalkyl, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower N- alkylaminosulfonyl, N-arylaminosulfonyl, arylsulfonyl, lower N,N-dialkylaminosulfonyl, lower N-alkyl-N- arylaminosulfonyl, lower cycloalkyl, heterocyclic, lower heterocyclicalkyl and lower aralkyl; wherein R 4 is selected from lower aralkenyl, aryl, lower cycloalkyl, lower cycloalkenyl and five to ten membered heterocyclic; wherein R 4 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, lower alkenyl, lower alkylsulfonyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower N-alkylaminocarbonyl, N- arylaminocarbonyl, lower N,N-dialkylaminocarbonyl, lower N-alkyl-N-arylaminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, sulfamyl, lower N-alkylaminosulfonyl, amino, lower N- alkylamino, lower N,N-dialkylamino, five- or six- membered heterocyclic, lower cycloalkylalkyl, nitro, acylamino , or wherein R 3 and R 4 together form wherein m is 1 to 3, inclusive; wherein A is selected from phenyl and five or six membered heteroaryl; wherein R 5 is lower alkyl; wherein R^ is one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower N- alkylaminocarbonyl, N-arylaminocarbonyl, lower alkyl, lower alkenyl, lower N,N-dialkylaminocarbonyl, lower N- alkyl-N-arylaminocarbonyl, lower haloalkyl, hydrido, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, sulfamyl, lower N-alkylaminosulfonyl, amino, lower N-alkylamino, lower N,N-dialkylamino, five- or six membered heterocyclic, lower cycloalkylalkyl, nitro and acylamino; and wherein R 7 is selected from hydrido, lower alkyl, aryl and lower aralkyl; or a pharmaceutically-acceptable salt thereof. A more preferred class of compounds consists of those compounds of Formula I wherein R 1 is phenyl, wherein R 1 is substituted at a substitutable position with one or more radicals selected from sulfamyl, halo, lower alkyl, lower alkoxy, hydroxyl, lower haloalkyl and wherein R 2 is selected from hydrido, lower alkyl, lower haloalkyl, cyano, carboxyl, lower alkoxycarbonyl, lower carboxyalkyl, lower cyanoalkyl, lower alkoxycarbonylcyanoalkenyl, lower haloaralkyl, lower carboxyhaloalkyl, lower alkoxycarbonylhaloalkyl, lower aminocarbonylhaloalkyl, lower alkylaminocarbonylhaloalkyl, lower N-alkylamino, lower N,N-dialkylamino, N-arylamino, lower N-aralkylamino, lower N-alkyl-N-aralkylamino, lower N-alkyl-N-arylamino, lower aminoalkyl, lower N-alkylaminoalkyl, lower N,N- dialkylaminoalkyl, lower N-arylaminoalkyl, lower N- aralkylaminoalkyl, lower N-alkyl-N-aralkylaminoalkyl, lower N-alkyl-N-arylaminoalkyl, aryloxy, lower aralkoxy, lower alkoxy, lower alkylthio, arylthio, lower aralkylthio, aminocarbonyl, lower aminocarbonylalkyl, lower N-alkylaminocarbonyl, N-arylaminocarbonyl, lower N,N-dialkylaminocarbonyl, lower N-alkyl-N- arylaminocarbonyl, lower cycloalkylaminocarbonyl, lower carboxyalkylaminocarbonyl, lower aralkoxycarbonylalkylaminocarbonyl, lower hydroxyalkyl, wherein R3 is selected from hydrido, lower alkyl, halo, cyano, lower hydroxyalkyl, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower alkoxy, lower N-alkylamino, lower N,N-dialkylamino, lower N- alkylaminosulfonyl, N-arylaminosulfonyl, arylsulfonyl, lower N,N-dialkylaminosulfonyl, lower N-alkyl-N- arylaminosulfonyl and lower cycloalkyl; wherein R^ is selected from lower aralkenyl, aryl, lower cycloalkyl, lower cycloalkenyl and five to ten membered heterocyclic; wherein R 4 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, lower alkenyl, lower alkylsulfonyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, sulfamyl, lower alkylaminosulfonyl, amino, lower N-alkylamino, lower N,N-dialkylamino, five or six membered heterocyclic, lower cycloalkylalkyl, nitro, or wherein R3 and R 4 together form wherein m is 2; wherein A is selected from phenyl and five or six membered heteroaryl; wherein R 5 is lower alkyl; wherein R^ is one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, lower alkenyl, lower alkylsulfonyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, sulfamyl, amino, lower N-alkylamino, lower N,N-dialkylamino, lower cycloalkylalkyl and nitro; and wherein R 7 is selected from hydrido, lower alkyl, aryl and lower aralkyl; or a pharmaceutically-acceptable salt thereof. An even more preferred class of compounds consists of those compounds of Formula I wherein R 1 is phenyl, wherein R1 is substituted at a substitutable position with one or more radicals selected from sulfamyl, halo, lower alkyl, lower alkoxy and wherein R 2 is selected from hydrido, lower alkyl, lower haloalkyl, cyano, carboxyl, lower alkoxycarbonyl, lower carboxyalkyl, lower cyanoalkyl, lower alkoxycarbonylcyanoalkenyl, lower haloaralkyl, lower carboxyhaloalkyl, lower alkoxycarbonylhaloalkyl, lower aminocarbonylhaloalkyl, lower alkylaminocarbonylhaloalkyl, lower N-alkylamino, lower N,N-dialkylamino, N-arylamino, lower N-aralkylamino, lower N-alkyl-N-aralkylamino, lower N-alkyl-N-arylamino, lower aminoalkyl, lower N-alkylaminoalkyl, lower N,N- dialkylaminoalkyl, lower N-arylaminoalkyl, lower N- aralkylaminoalkyl, lower N-alkyl-N-aralkylaminoalkyl, lower N-alkyl-N-arylaminoalkyl, lower alkoxy, aryloxy, lower aralkoxy, lower alkylthio, arylthio, lower aralkylthio, aminocarbonyl, lower aminocarbonylalkyl, lower N-alkylaminocarbonyl, N-arylaminocarbonyl, lower N,N-dialkylaminocarbonyl, lower N-alkyl-N- arylaminocarbonyl, lower cycloalkylaminocarbonyl, lower carboxyalkylaminocarbonyl, lower heterocyclicaminocarbonyl, lower aralkoxycarbonylalkylaminocarbonyl, lower hydroxyalkyl, κ 7 7 R 7 N. ^NH 2 N NH 2 ' CH . Y ^ , and / γ. 0 s 0 wherein R^ is selected from hydrido, lower alkyl, halo, cyano, lower hydroxyalkyl, lower alkoxy, lower N- alkylamino, lower N,N-dialkylamino, lower alkylthio, lower alkylsulfonyl and lower cycloalkyl; wherein R 4 is selected from lower aralkenyl, aryl, lower cycloalkyl, lower cycloalkenyl and five to ten membered heterocyclic; wherein R 4 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, lower alkenyl, lower alkylsulfonyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, sulfamyl, amino, lower N-alkylamino, lower N,N-dialkylamino, five or six membered heterocyclic, lower cycloalkylalkyl, nitro, or wherein R-^and R 4 together form wherein m is 2; wherein A is selected from phenyl and five membered heteroaryl; wherein R 5 is lower alkyl; wherein R^ is one or more radicals selected from halo, lower alkyl, lower alkylsulfonyl, lower haloalkyl, lower alkoxy, sulfamyl, amino and nitro; and wherein R 7 is selected from hydrido, lower alkyl, aryl and lower aralkyl; or a pharmaceutically-acceptable salt thereof. Within Formula I there is a subclass of compounds which consists of compounds wherein Rl is phenyl substituted at a substitutable position with one or more radicals selected from halo, lower alkyl, sulfamyl and wherein R 2 is selected from hydrido, lower alkyl, lower haloalkyl, cyano, carboxyl, lower alkoxycarbonyl, lower carboxyalkyl, lower cyanoalkyl, lower alkoxycarbonylcyanoalkenyl, lower haloaralkyl, lower carboxyhaloalkyl, lower alkoxycarbonylhaloalkyl, lower aminocarbonylhaloalkyl, lower alkylaminocarbonylhaloalkyl, lower N-alkylamino, lower N,N-dialkylamino, N-arylamino, lower N-aralkylamino, lower N-alkyl-N-aralkylamino, lower N-alkyl-N-arylamino, lower aminoalkyl, lower N-alkylaminoalkyl, lower N,N- dialkylaminoalkyl, lower N-arylaminoalkyl, lower N- aralkylaminoalkyl, lower N-alkyl-N-aralkylaminoalkyl, lower N-alkyl-N-arylaminoalkyl, lower alkoxy aryloxy, lower aralkoxy, lower alkylthio, arylthio, lower aralkylthio, aminocarbonyl, lower aminocarbon lalkyl, lower N-alkylaminocarbonyl, N-arylaminocarbonyl, lower N,N-dialkylaminocarbonyl, lower N-alkyl-N- arylaminocarbonyl, lower cycloalkylaminocarbonyl, lower carboxyalkylaminocarbonyl, lower aralkoxycarbonylalkylaminocarbonyl, lower hydroxyalkyl, R' and CH 3 N γ wherein R 3 is selected from hydrido, lower alkyl, halo, cyano, lower hydroxyalkyl, lower alkoxy, lower alkylthio, lower N-alkylamino, lower N,N-dialkylamino, lower alkylsulfonyl and lower cycloalkyl; wherein R 4 is selected from lower aralkenyl, aryl, lower cycloalkyl, lower cycloalkenyl and five to ten membered heterocyclic; wherein R 4 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, lower alkenyl, lower alkylsulfonyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, sulfamyl, lower alkylaminocarbonyl, amino, lower N-alkylamino, lower N,N-dialkylamino, five or six membered heterocyclic, lower cycloalkylalkyl, nitro, wherein R 5 is lower alkyl; and wherein R 7 is selected from hydrido, lower alkyl, aryl and lower aralkyl; or a pharmaceutically-acceptable salt thereof. A class of compounds of particular interest consists of those compounds of Formula I wherein Rl is phenyl, substituted at a substitutable position with one or more radicals selected from fluoro, chloro, methyl, sulfamyl and 9*.p H CH 3 S-N=C-N S ; CH 3 wherein R 2 is selected from hydrido, methyl, ethyl, isopropyl, tert-butyl, isobutyl, hexyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, cyano, carboxyl, methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl, tert-butoxycarbonyl, propoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, pentoxycarbonyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, pivaloyl, hexanoyl, trifluoroacetyl, cyanomethyl, ethoxycarbonylcyanoethenyl, 1, 1-difluoro-1-phenylmethyl, 1,1-difluoro-1-phenylethyl, difluoroacetyl, methoxycarbonyldifluoromethyl, difluoroacetamidyl, N,N- dimethyldifluoroacetamidyl, N-phenyldifluoroacetamidyl, N-ethylamino, N-methylamino, N,N-dimethylamino, N,N- diethylamino, N-phenylamino, N-benzylamino, N- phenylethylamino, N-methyl-N-benzylamino, N-ethyl-N- phenylamino, N-methy1-N-phenylamino, aminome hyl, N- methylaminomethyl, N,N-dimethylaminomethyl, N- phenylaminomethyl, N-benzylaminomethyl, N-methyl-N- benzylaminomethyl, N-methyl-N-phenylaminomethyl, methoxy, ethoxy, phenoxy, benzyloxy, methylthio, phenylthio, benzylthio, N-methylurea, N-methylthiourea, N-methylacetamidyl, urea, ureamethyl, thiourea, thioureamethyl, acetamidyl, N-phenylthioureamethyl, N- benzylthioureamethyl, N-methylthioureamethyl, N- phenylureamethyl, N-benzylureamethyl, N- methylureamethyl, N-phenylacetamidylmethyl, N- benzylacetamidylmethyl, N-methylacetamidylmethyl, aminocarbonyl, aminocarbonylmethyl, N- methylaminocarbonyl, N-ethylaminocarbonyl, N- isopropylaminocarbonyl, N-propylaminocarbonyl, N- butylaminocarbonyl, N-isobutylaminocarbonyl, N-tert- butylaminocarbonyl, N-pentylaminocarbonyl, N- phenylaminocarbonyl, N,N-dimethylaminocarbonyl, N- methyl-N-ethylaminocarbonyl, N- (3- fluorophenyl)aminocarbonyl, N- (4- methylphenyl)aminocarbonyl, N- (3- chloropheny1)aminocarbonyl, N-methy1-N- (3- chloropheny1)aminocarbonyl, N- (4- methoxyphenyl)aminocarbonyl, N-methy1-N- phenylaminocarbonyl, eyelopentylaminocarbonyl, cyclohexylaminocarbonyl, carboxymethylaminocarbonyl, benzyloxycarbonylmethylaminocarbonyl, hydroxypropyl, hydroxymethyl, and hydroxypropyl; wherein R 3 is selected from hydrido, methyl, ethyl, isopropyl, tert-butyl, isobutyl, hexyl, fluoro, chloro, bromo, cyano, methoxy, methylthio, methylsulfonyl, N-methylamino, N-ethylamino, N,N-dimethylamino, N,N-diethylamino, cyclopropyl, cyclopentyl, hydroxypropyl, hydroxymethyl, and hydroxyethyl; and wherein R 4 is selected from phenylethenyl, phenyl, naphthyl, biphenyl, cyclohexyl, cyclopentyl, cycloheptyl, 1-cyclohexenyl, 2- cyclohexenyl, 3-cyclohexenyl, 4-cyclohexenyl, 1- cyclopentenyl, 4-cyclopentenyl, benzofuryl, 2,3- dihydrobenzofuryl, 1,2,3, 4-tetrahydronaphthyl, benzothienyl, indenyl, indanyl, indolyl, dihydroindolyl, chromanyl, benzopyran, thiochromanyl, benzothiopyran, benzodioxolyl, benzodioxanyl, pyridyl, thienyl, thiazolyl, oxazolyl, furyl and pyrazinyl; wherein R 4 is optionally substituted at a substitutable position with one or more radicals selected from fluoro, chloro, bromo, methylthio, methylsulfinyl, methyl, ethyl, propyl, isopropyl, tert-butyl, isobutyl, hexyl, ethylenyl, propenyl, methylsulfonyl, cyano, carboxyl, methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl, tert-butoxycarbonyl, propoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, pentoxycarbonyl, aminocarbonyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethy1, heptafluoropropyl, bromodifluoromethyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, hydroxyl, methoxy, methylenedioxy, ethoxy, propoxy, n-butoxy, sulfamyl, methylaminosulfonyl, hydroxypropyl, hydroxyisopropyl, hydroxymethyl, hydroxyethy1, trifluoromethoxy, amino, N- methylamino, N-ethylamino, N-ethyl-N-methylamino, N,N- dimethylamino, N,N-diethylamino, formylamino, methylcarbonylamino, trifluoroacetamino, piperadinyl, piperazinyl, morpholino, cyclohexylmethyl, cyclopropylmethyl, cyclopentylmethyl, nitro, and wherein R 7 is selected from hydrido, methyl, ethyl, phenyl and benzyl; or a pharmaceutically-acceptable salt thereof. Within Formula I there is a second subclass of compounds of high interest wherein R^ is phenyl substituted at a substitutable position with sulfamyl; wherein R 2 is selected from lower haloalkyl, cyano, carboxyl, lower alkoxycarbonyl, lower carboxyalkyl, aminocarbonyl, lower N-alkylaminocarbonyl, N- arylaminocarbonyl, lower N,N-dialkylaminocarbonyl, lower N-alkyl-N-arylaminocarbonyl, lower cycloalkylaminocarbonyl and lower hydroxyalkyl; wherein R 3 and R 4 together form wherein m is 2; wherein A is selected from phenyl and five membered heteroaryl; and wherein R^ is one or more radicals selected from halo, lower alkyl, lower alkylsulfonyl, lower haloalkyl, lower alkoxy, amino and nitro; or a pharmaceutically-acceptable salt thereof. A class of compounds of particular interest consists of those compounds of Formula I wherein R 2 is selected from fluoromethyl, difluorome hyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, cyano, carboxyl, methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl, tert- butoxycarbonyl, propoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, pentoxycarbonyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, pivaloyl, hexanoyl, trifluoroacetyl, aminocarbonyl, N- methylaminocarbonyl, N-ethylaminocarbonyl, N- isopropylaminocarbonyl, N-propylaminocarbonyl, N- butylaminocarbonyl, N-isobutylaminocarbonyl, N- ert- butylaminocarbonyl, N-pentylaminocarbonyl, N- phenylaminocarbonyl, N,N-dimethylaminocarbonyl, N-methy1-N- ethylaminocarbonyl, N- (3-fluorophenyl)aminocarbonyl, N-(4- methylpheny1)aminocarbonyl, N- (3- chloropheny1)aminocarbonyl, N-(4- methoxypheny1)aminocarbonyl, N-methy1-N- phenylaminocarbonyl, cyclohexylaminocarbonyl, hydroxypropyl, hydroxymethyl and hydroxyethyl; wherein A is selected from phenyl, furyl and thienyl; and wherein R^ is one or more radicals selected from fluoro, chloro, bromo, methylsulfonyl, methyl, ethyl, isopropyl, tert-butyl, isobutyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, methoxy, methylenedioxy, ethoxy, propoxy, n-butoxy, amino, and nitro; or a pharmaceutically-acceptable salt thereof. Within Formula I there is a third subclass of compounds of high interest wherein R 1 is selected from phenyl, naphthyl, biphenyl, and five- or six-membered heteroaryl, wherein R^- is substituted at a substitutable position with one or more radicals selected from halo, lower alkyl, lower alkoxy, hydroxyl and lower haloalkyl; wherein R 2 is selected from lower haloalkyl; wherein R 3 is hydrido; and wherein R 4 is aryl substituted at a substitutable position with sulfamyl; or a pharmaceutically-acceptable salt thereof. A class of compounds of particular interest consists of those compounds of Formula I wherein R 1 is selected from phenyl, naphthyl, benzofuryl, benzothienyl, indolyl, benzodioxolyl, benzodioxanyl, pyridyl, thienyl, thiazolyl, oxazolyl, furyl and pyrazinyl; wherein R 1 is substituted at a substitutable position with one or more radicals selected from fluoro, chloro, bromo, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichloropropyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, methyl, ethyl, propyl, hydroxyl, methoxy, ethoxy, propoxy and n- butoxy; wherein R 2 is selected from fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, difluoroethyl, dichlorofluoromethyl, difluoropropyl, dichloroethyl and dichloropropyl; wherein R 3 is hydrido; and wherein R 4 is phenyl substituted at a substitutable position with sulfamyl; or a pharmaceutically-acceptable salt thereof. Within Formula I there is a subclass of compounds of high interest represented by Formula II: wherein R 2 is selected from hydrido, alkyl, haloalkyl, alkoxycarbonyl, cyano, cyanoalkyl, carboxyl, aminocarbonyl, alkylaminocarbonyl, cycloalkylaminocarbonyl, arylaminocarbonyl, carboxyalkylaminocarbonyl, carboxyalkyl, aralkoxycarbonylalkylaminocarbonyl, aminocarbonylalkyl, alkoxycarbonylcyanoalkenyl and hydroxyalkyl; wherein R 3 is selected from hydrido, alkyl, cyano, hydroxyalkyl, cycloalkyl, alkylsulfonyl and halo; and wherein R 4 is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R 4 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfonyl, cyano, nitro, haloalkyl, alkyl, hydroxyl, alkenyl, hydroxyalkyl, carboxyl, cycloalkyl, alkylamino, dialkylamino, alkoxycarbonyl, aminocarbonyl, alkoxy, haloalkoxy, sulfamyl, heterocyclic and amino; provided R 2 and R 3 are not both hydrido; further provided that R 2 is not carboxyl or methyl when R 3 is hydrido and when R 4 is phenyl; further provided that R 4 is not triazolyl when R 2 is methyl; further provided that R 4 is not aralkenyl when R 2 is carboxyl, aminocarbonyl or ethoxycarbonyl; further provided that R 4 is not phenyl when R 2 is methyl and R 3 is carboxyl; and further provided that R 4 is not unsubstituted thienyl when R 2 is trifluoromethyl; or a pharmaceutically- acceptable salt thereof. A class of compounds of particular interest consists of those compounds of Formula II wherein R 2 is selected from hydrido, lower alkyl, lower haloalkyl, lower alkoxycarbonyl, cyano, lower cyanoalkyl, carboxyl, aminocarbonyl, lower alkylaminocarbonyl, lower cycloalkylaminocarbonyl, arylaminocarbonyl, lower carboxyalkylaminocarbonyl, lower aralkoxycarbonylalkylaminocarbony1, lower aminocarbonylalkyl, lower carboxyalkyl, lower alkoxycarbonylcyanoalkenyl and lower hydroxyalkyl; wherein R3 is selected from hydrido, lower alkyl, cyano, lower hydroxyalkyl, lower cycloalkyl, lower alkylsulfonyl and halo; and wherein R 4 is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R 4 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfonyl, cyano, nitro, lower haloalkyl, lower alkyl, hydroxyl, lower alkenyl, lower hydroxyalkyl, carboxyl, lower cycloalkyl, lower alkylamino, lower dialkylamino, lower alkoxycarbonyl, aminocarbonyl, lower alkoxy, lower haloalkoxy, sulfamyl, five or six membered heterocyclic and amino; or a pharmaceutically-acceptable salt thereof. A family of specific compounds of particular interest within Formula I consists of compounds and pharmaceutically-acceptable salts thereof as follows: 4-[5- (4- (N-ethylamino)phenyl)-3- (trifluoromethyl)-1H- pyrazol-1-yl] enzenesulfonamide; 4-[5-(4-(N-ethyl-N-methylamino)phenyl)-3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4-[5- (3-fluoro-4- (N-methylamino)phenyl) -3- (trifluoromethyl)-lH-pyrazol-1-yl]benzenesulfonamide; 4-[5- (3-chloro-4- (N-methylamino)phenyl) -3- ( rifluoromethyl)-lH-pyrazol-1-yl]benzenesulfonamide; 4-[5- (3-methyl-4- (N-methylamino)phenyl) -3- (trifluoromethyl)-lH-pyrazol-l-yl]benzenesulfonamide; 4-[5- (4- (N,N-dimethylamino)-3-fluorophenyl)-3- (trifluoromethyl)-lH-pyrazol-1-yl]benzenesulfonamide; 4-[5-(3-chloro-4-(N,N-dimethylamino)phenyl)-3- (trifluoromethyl)-lH-pyrazol-1-yl]benzenesulfonamide; 4-[5- (4- (N,N-dimethylamino) -3-methylphenyl)-3- (trifluoromethyl)-lH-pyrazol-1-yl]benzenesulfonamide; 4-[5-(4- (N-ethyl-N-methylamino)-3-fluorophenyl) -3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4-[5-(3-chloro-4- (N-ethyl-N-methylamino)phenyl) -3- (trifluoromethyl)-lH-pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-(N-ethyl-N-methylamino)-3-methylphenyl)-3- (trifluoromethyl)-lH-pyrazol-1-yl]benzenesulfonamide; 4-[5-(4-(N,N-diethylamino)-3-fluorophenyl)-3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4-[5-(4- (3-chloro-4-(N,N-diethylamino)phenyl) -3- ( rifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4-[5-(4-(N,N-diethylamino)-3-methylphenyl) -3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; N-[4-[l-[4- (aminosulfonyl)phenyl] -3-(trifluoromethyl) - lH-pyrazol-5-yl] -3-fluorophenyl] -N-methylacetamide; N-[4-[1-[4- (aminosulfonyl)phenyl] -3- (trifluoromethyl) - lH-pyrazol-5-yl] -3-chlorophenyl] -N-methylacetamide; N-[4- [1-[4-(aminosulfonyl)phenyl] -3- (trifluoromethyl) - lH-pyrazol-5-yl] -3-methylphenyl] -N-methylacetamide; N-[4-[1-[4-(aminosulfonyl)phenyl] -3- (trifluoromethyl) - lH-pyrazol-5-yl] -3-fluorophenyl] -N-methylurea; N-[4-[1-[4- (aminosulfonyl)phenyl]-3-(trifluoromethyl)- lH-pyrazol-5-yl] -3-chlorophenyl] -N-methylurea; N-[4-[1-[4-(aminosulfonyl)phenyl] -3-(trifluoromethyl) - lH-pyrazol-5-yl] -3-methylphenyl] -N-methylurea; N-[4-[1-[4-(aminosulfonyl)phenyl] -3- (trifluoromethyl) - lH-pyrazol-5-yl] -3-fluorophenyl]-N-methylthiourea; N-[4-[1-[4- (aminosulfonyl)phenyl] -3- (trifluoromethyl) - lH-pyrazol-5-yl] -3-chlorophenyl] -N-methylthiourea; N-[4-[1-[4- (aminosulfonyl)phenyl] -3- (trifluoromethyl) - lH-pyrazol-5-yl] -3-methylphenyl] -N-methylthiourea; 4-[5-(3-(N,N-dimethylamino)phenyl) -3-(trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4-[5- (3- (N-ethyl-N-methylamino)phenyl)-3- (trifluoromethyl) -lH-pyrazol-1-y1]benzenesulfonamide; 4-[5- (4-chloro-3- (N-methylamino)phenyl) -3- (trifluoromethyl)-lH-pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-methyl-3- (N-methylamino)phenyl) -3- (trifluoromethyl) -lH-pyrazol-l-yl]benzenesulfonamide; N-[3-[l-[4- (aminosulfonyl)phenyl] -3- (trifluoromethyl) - lH-pyrazol-5-yl]phenyl]-N-methylacetamide; N-[3-[l-[4-(aminosulfonyl)phenyl] -3- (trifluoromethyl) - lH-pyrazol-5-yl] -4-fluorophenyl] -N-methylacetamide; N-[3-[1-[4- (aminosulfonyl)phenyl] -3-(trifluoromethyl) - lH-pyrazol-5-yl] -4-methylphenyl] -N-methylurea; N-[3-[1-[4- (aminosulfonyl)phenyl]-3- (trifluoromethyl)- lH-pyrazol-5-yl] -4-fluorophenyl] -N-methylthiourea; 4-[5-(2-(N-ethyl-N-methylamino) -4-methylphenyl) -3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; N-[2-[l-[4- (aminosulfonyl)phenyl] -3- (trifluoromethyl) - lH-pyrazol-5-yl] -4-methylphenyl] -N-methylurea; N-[2- [1-[4- (aminosulfonyl)phenyl] -3- (trifluoromethyl) - lH-pyrazol-5-yl] -4-fluorophenyl] -N-methylthiourea,- 4-[5- (lH-indol-5-yl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (7-fluoro-lH-indol-5-yl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (l-ethyl-lH-indol-5-yl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (7-methyl-lH-indol-5-yl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide, • 4-[5-(7-chloro-l-methyl-lH-indol-5-yl)-3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (2,3-dihydro-lH-indol-5-yl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (7-fluoro-l-methyl-2,3-dihydro-lH-indol-5-yl)-3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4- [3-aminomethyl-5-pheny1-lH-pyrazol-1- yl]benzenesulfonamide; 4- [3- (N-methylamino)methyl-5-phenyl-lH-pyrazol-1- yl]benzenesulfonamide; 4- [3- (N,N-dimethylamino)methyl-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4- [5-phenyl-3- (N-phenylamino)methyl-lH-pyrazol-1- y1]benzenesulfonamide; 4-[3- (N-benzylamino)methyl-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[3- (N-benzyl-N-methylamino)methyl-5-phenyl-lH-pyrazol- 1-y1]benzenesulfonamide; 4-[3- (N-methyl-N-phenylamino)methyl-5-phenyl-lH-pyrazol- l-yl]benzenesulfonamide; N-[ [1- [4- (aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- y1]methyl]acetamide; N- [ [1- [4-(aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- yl]methyl] -N-methylacetamide; N- [ [1- [4- (aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- yl]methyl] -N-phenylacetamide; N-[ [l-[4- (aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- yl]methyl] -N-benzylacetamide; N-[ [1-[4-(aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- y1]methyl]urea; N-[ [1-[4-(aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- yl]methyl]-N-methylurea; N-[ [1-[4-(aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- yl]methyl] -N-phenylurea; N-[ [1-[4-(aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- y1]methyl]-N-benzylurea; N-[ [1-[4-(aminosulfonyl)phenyl]-5-phenyl-lH-pyrazol-3- yl]methyl]thiourea; N-[ [1-[4-(aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- yl]methyl] -N-methylthiourea; N-[ [l-[4-(aminosulfonyl)phenyl]-5-phenyl-lH-pyrazol-3- yl]methyl] -N-pheny1thiourea; N-[ [1-[4-(aminosulfonyl)phenyl]-5-phenyl-lH-pyrazol-3- yl]methyl] -N-benzylthiourea; 4-[4-methoxy-5-phenyl-3- (trifluoromethyl) -lH-pyrazol-1- y1]benzenesulfonamide; 4-[4-methylthio-5-phenyl-3-(trifluoromethyl) -iH-pyrazol- 1-yl]benzenesulfonamide; 4-[4- (N-methylamino) -5-phenyl-3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[4- (N,N-dimethylamino)-5-phenyl-3- (trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4-[3-me hoxy-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[3-ethoxy-5-phenyl-lH-pyrazol-l-yl]benzenesulfonamide; 4-[3-phenoxy-5-phenyl-lH-pyrazo1-1- yl]benzenesulfonamide; 4-[3-benzyloxy-5-phenyl-lH-pyrazol-1- y1]benzenesulfonamide; 4-[3-methylthio-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[3-benzylthio-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[3- (N-methylamino)-5-phenyl-lH-pyrazol-l- y1]benzenesulfonamide; 4- [ 3 - (N , N-dimethylamino ) -5-phenyl-lH-pyrazol-l- y1]benzenesulfonamide; 4- [3- (N-benzyl-N-methylamino) -5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; N- [1- [4- (aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- yl]acetamide; N- [1- [4- (aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- yl] -N-methylacetamide; N- [1- [4- (aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- yl] -N-benzylacetamide; N- [1- [4- (aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- yl]urea; N- [1- [4- (aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- yl] -N-methylurea; N- [1- [4- (aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- yl] -N-benzylurea; N- [1- [4- (aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- yl] thiourea; N- [1- [4- (aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- yl] -N-methylthiourea; N- [1- [4- (aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- yl] -N-benzylthiourea; 4-[5-phenyl-3- (1, 1-difluoro-1-phenylmethyl) -lH-pyrazol- 1-y1]benzenesulfonamide; 4-[5-phenyl-3-(l,l-difluoro-2-phenylethyl)-lH-pyrazol-l- yl]benzenesulfonamide; 1-[4- (aminosulfonyl)phenyl] -5-phenyl-lH-pyrazole-3- difluoroacetic acid; methyl 1- [4- (aminosulfonyl)phenyl] -5-phenyl-lH-pyrazole- 3-difluoroacetate; 1- [4- (aminosulfonyl)phenyl] -5-phenyl-lH-pyrazole-3- difluoroacetamide; N,N-dimethyl-l- [4- (aminosulfonyl)phenyl] -5-phenyl-lH- pyrazole-3-difluoroacetamide; N-phenyl-l-[4- (aminosulfonyl)phenyl] -5-phenyl-lH- pyrazole-3-difluoroacetamide; l-[4-(aminosulfonyl)phenyl]-5-phenyl-lH-pyrazole-3- acetic acid; 1-[4-(aminosulfonyl)phenyl] -4-chloro-5-phenyl-lH- pyrazole-3-difluoroacetic acid; 1-[4- (aminosulfonyl)phenyl]-4-bromo-5-phenyl-1H- pyrazole-3-difluoroacetic acid; 1-[4- (aminosulfonyl)phenyl]-4-chloro-5- (4-chlorophenyl) - lH-pyrazole-3-acetic acid; 1-[4- (aminosulfonyl)phenyl] -4-bromo-5-phenyl-lH- pyrazole-3-acetic acid; (R) -2-[1-[4- (aminosulfonyl)phenyl]-5-phenyl-lH-pyrazol- 3-yl]propanoic acid; (S)-2-[1-[4- (aminosulfonyl)phenyl]-5-phenyl-lH-pyrazol- 3-yl]propanoic acid; (R) -2-[1-[4- (aminosulfonyl)phenyl] -4-chloro-5-phenyl-lH- pyrazol-3-yl]propanoic acid; (S) -2-[1-[4- (aminosulfonyl)phenyl] -4-chloro-5-phenyl-lH- pyrazol-3-yl]propanoic acid; (R)-2-[1-[4- (aminosulfonyl)phenyl] -4-bromo-5-phenyl-1H- pyrazol-3-yl]propanoic acid; (S) -2-[1-[4- (aminosulfonyl)phenyl]-4-bromo-5-phenyl-lH- pyrazol-3-yl]propanoic acid; 2-[1-[4-(aminosulfonyl)phenyl] -5-phenyl-lH-pyrazol-3- yl] -2-methylpropanoic acid; 2-[1-[4- (aminosulfonyl)phenyl]-4-chloro-5-phenyl-lH- pyrazol-3-yl] -2-methylpropanoic acid; 2-[1-[4-(aminosulfonyl)phenyl] -4-bromo-5-phenyl-1H- pyrazol-3-yl] -2-methylpropanoic acid; 2-fluoro-4-[5-phenyl-3-(trifluoromethyl)-lH-pyrazol-1- y1]benzenesulfonamide; 3-fluoro-4-[5-phenyl-3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide, • 2-methyl-4-[5-phenyl-3-(trifluoromethyl) -lH-pyrazol-1- y1]benzenesulfonamide; 3-methyl-4-[5-phenyl-3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; ethyl 1-[4- (aminosulfonyl)phenyl] -5- (4-chloropheny1) -1H- pyrazole-3-carboxylate; ethyl l-[4-(aminosulfonyl)phenyl]-5- (4-methylphenyl)-1H- pyrazole-3-carboxylate; isopropyl 1-[4- (aminosulfonyl)phenyl]-5-(4- chlorophenyl)-lH-pyrazole-3-carboxylate; methyl-1-[4- (aminosulfonyl) henyl] -5-(4-aminophenyl) -1H- pyrazole-3-carboxylate; 1-[4- (aminosulfonyl)phenyl] -5- (4-chlorophenyl)-1H- pyrazole-3-carboxylic acid; tert-butyl-1-[4-(aminosulfonyl)phenyl]-5-(4- chlorophenyl) -lH-pyrazole-3-carboxylate; propyl-1-[4- (aminosulfonyl)phenyl] -5-(4-chlorophenyl) - lH-pyrazole-3-carboxylate; butyl-1-[4- (aminosulfonyl) henyl]-5-(4-chlorophenyl)-1H- pyrazole-3-carboxylate; isobutyl-1-[4- (aminosulfonyl)phenyl]-5- (4-chlorophenyl)- lH-pyrazole-3-carboxylate; pentyl-1-[4-(aminosulfonyl)phenyl]-5- (4-chlorophenyl) - lH-pyrazole-3-carboxylate; methyl-1-[4-(aminosulfonyl)phenyl] -5-(4-chloropheny1) - lH-pyrazole-3-carboxylate; methyl-1-[4- (aminosulfonyl)phenyl]-5-(4-methylphenyl) - lH-pyrazole-3-carboxylate; methyl-1-[4- (aminosulfonyl)phenyl]-5- (4-methoxyphenyl) - lH-pyrazole-3-carboxylate; methyl-1-[4- (aminosulfonyl)phenyl] -5-(4-bromophenyl) -1H- pyrazole-3-carboxylate; methyl-1-[4-(aminosulfonyl)phenyl]-5- (4-nitrophenyl)-1H- pyrazole-3-carboxylate; methyl-1-[4- (aminosulfonyl)phenyl] -5- (4-fluorophenyl) - lH-pyrazole-3-carboxylate; methyl-1-[4- (aminosulfonyl)phenyl] -5-(3,5-dichloro-4- methoxyphenyl)-lH-pyrazole-3-carboxylate; methyl-1-[4-(aminosulfonyl)phenyl]-5-(3,5-difluoro-4- methoxyphenyl) -lH-pyrazole-3-carboxylate; N-[4-methylpheny1] -1-[4- (aminosulfony1)phenyl]-5- (4- fluorophenyl) -lH-pyrazole-3-carboxamide; N-[3-chloropheny1] -l-[4-(aminosulfonyl)phenyl] -5- (4- fluorophenyl) -lH-pyrazole-3-carboxamide; N-[3-fluorophenyl] -1-[4-(aminosulfonyl)phenyl]-5- (4- fluorophenyl)-lH-pyrazole-3-carboxamide; N- [3-fluorophenyl] -1- [4- (aminosulfonyl)phenyl] -5- (4- chlorophenyl) -lH-pyrazole-3-carboxamide; phenylmethyl N- [ [1-[4- (aminosulfonyl)phenyl] -5- (4- chlorophenyl) -lH-pyrazol-3-yl]carbonyl]glycinate; l-[4- (aminosulfonyl)phenyl] -5- (4-bromophenyl) -1H- pyrazole-3-carboxamide; 1- [4- (aminosulfonyl)phenyl] -5- (4-chlorophenyl) -1H- pyrazole-3-carboxamide; N-phenyl-1-[4- (aminosulfonyl)phenyl] -5- (4-fluorophenyl) - lH-pyrazole-3-carboxamide; N- (4-methoxyphenyl) -1- [4- (aminosulfonyl)phenyl] -5- (4- fluorophenyl) -lH-pyrazole-3-carboxamide; N- (4-methylphenyl) -1- [4- (aminosulfonyl)phenyl] -5- (4- chlorophenyl) -lH-pyrazole-3-carboxamide; N,N-dimethyl-l- [4- (aminosulfonyl)phenyl] -5- (4- chlorophenyl) -lH-pyrazole-3-carboxamide; N-methyl-1- [4- (aminosulfonyl)phenyl] -5- (4-chlorophenyl) - lH-pyrazole-3-carboxamide; N-methyl-N-ethyl-1- [4- (aminosulfonyl)phenyl] -5- (4- chlorophenyl) -lH-pyrazole-3-carboxamide; N-phenyl-1-[4- (aminosulfonyl)phenyl] -5- (4-chlorophenyl) - lH-pyrazole-3-carboxamide; N-methyl-N-phenyl-1- [4- (aminosulfonyl)phenyl] -5- (4- chlorophenyl) -lH-pyrazole-3-carboxamide; N-ethyl-1- [4- (aminosulfonyl)phenyl] -5- (4-chlorophenyl) - lH-pyrazole-3-carboxamide; N-isopropyl-1- [4- (aminosulfonyl)phenyl] -5- (4- chlorophenyl) -lH-pyrazole-3-carboxamide; N-propyl-l-[4- (aminosulfonyl)phenyl] -5- (4-chlorophenyl) - lH-pyrazole-3-carboxamide; N-butyl-1- [4- (aminosulfonyl)phenyl] -5- (4-chlorophenyl) - lH-pyrazole-3-carboxamide; N-isobutyl-l-[4- (aminosulfonyl)phenyl] -5- (4- chlorophenyl) -lH-pyrazole-3-carboxamide; N-tert-butyl-1- [4- (aminosulfonyl)phenyl] -5- (4- chlorophenyl) -lH-pyrazole-3-carboxamide; N-pentyl-1- [4- (aminosulfonyl)phenyl] -5- (4-chlorophenyl) - lH-pyrazole-3-carboxamide; N-cyclohexyl-1-[4- (aminosulfonyl)phenyl]-5-(4- fluorophenyl) -lH-pyrazole-3-carboxamide; N-cyclopentyl-1-[4-(aminosulfonyl)phenyl] -5-(4- chlorophenyl) -lH-pyrazole-3-carboxamide; 4-[5-(4-chlorophenyl)-3-(pyrrolidinocarboxamide)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5-(4-chlorophenyl) -3- (piperidinocarboxamide) -1H- pyrazol-1-yl]benzenesulfonamide; N- (3-chlorophenyl)-1-[4-(aminosulfonyl)phenyl]-5-(4- chlorophenyl) -lH-pyrazole-3-carboxamide; N-(2-pyridyl)-1-[4-(aminosulfonyl)phenyl]-5-(4- chlorophenyl) -lH-pyrazole-3-carboxamide; N-methyl-N-(3-chlorophenyl) -1-[4- (aminosulfonyl)phenyl]- 5- (4-chlorophenyl) -lH-pyrazole-3-carboxamide; 1-[4-(aminosulfonyl)phenyl]-5- (4-nitrophenyl)-1H- pyrazole-3-carboxamide; 1-[4- (aminosulfonyl)phenyl] -5- (4-fluorophenyl) -1H- pyrazole-3-carboxamide; 1-[4- (aminosulfonyl)phenyl]-5-phenyl-lH-pyrazole-3- carboxamide; 1-[4-(aminosulfonyl)phenyl] -5-(3-chloro-4- methoxyphenyl) -lH-pyrazole-3-carboxamide; 1-[4- (aminosulfonyl)phenyl]-5- (4-methylthiophenyl) -1H- pyrazole-3-carboxamide; 1-[4- (aminosulfonyl)phenyl]-5- (4-methoxyphenyl) -1H- pyrazole-3-carboxamide; 1-[4- (aminosulfonyl)phenyl]-5- (4-methylphenyl) -1H- pyrazole-3-carboxamide; N-methyl 1-[4- (aminosulfonyl)phenyl]-5- (4- methoxyphenyl) -lH-pyrazole-3-carboxamide; N-[ [1-[4-(aminosulfonyl) henyl]-5-(4-chlorophenyl) -1H- pyrazol-3-yl]carbonyl]glycine; 1-[4-(aminosulfonyl)phenyl]-5- (3-bromo-4-methoxyphenyl) - lH-pyrazole-3-carboxamide; 1-[4-(aminosulfonyl) henyl]-5-(3,5-dichloro-4- methoxypheny1) -lH-pyrazole-3-carboxamide; 4-[5-(4-bromophenyl) -3-cyano-lH-pyrazol-l- yl]benzenesulfonamide; 4-[3-cyano-5-(4-fluorophenyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-chlorophenyl)-3-cyano-lH-pyrazol-l- yl]benzenesulfonamide; 4-[3-cyano-5- (4-methoxyphenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[3-cyano-5- (4-methylphenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[3-cyano-5- (4-methylthiophenyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (3-chloro-4-methoxyphenyl) -3-cyano-lH-pyrazol-l- yl]benzenesulfonamide; 4-[5- (3,5-dichloro-4-methoxyphenyl) -3-cyano-lH-pyrazol- 1-y1]benzenesulfonamide; 4-[5-(3-bromo-4-methoxyphenyl) -3-cyano-lH-pyrazol-l- yl]benzenesulfonamide; 4-[3-cyano-5-phenyl-lH-pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-nitrophenyl)-3- (cyano)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-chloro-5-(4-fluorophenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-chloro-5- (4-chlorophenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-bromo-5- (4-chlorophenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-chloro-5-phenyl-lH-pyrazol-l-yl]benzenesulfonamide; 4-[4-chloro-5- (3 ,5-dichloro-4-methoxyphenyl) -lH-pyrazol- 1-y1]benzenesulfonamide; 4-[4-bromo-5-(4-methylphenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-chloro-5- (4-methylphenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-chloro-5- (3-chloro-4-methoxyphenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-chloro-5- (4-methoxyphenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-bromo-5- (4-methoxyphenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-cyano-5-(4-methoxyphenyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-chloro-5-(3,5-difluoro-4-methoxyphenyl) -lH-pyrazol- 1-y1]benzenesulfonamide; 4-[4-methyl-5-phenyl-lH-pyrazol-l-yl]benzenesulfonamide; 4-[4-fluoro-5-phenyl-lH-pyrazol-l-yl]benzenesulfonamide; 4-[5- (4-chlorophenyl) -4-methylsulfonyl-lH-pyrazol-l- y1]benzenesulfonamide; 4-[4-chloro-5- (4-chlorophenyl) -3- (trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[4-ethyl-5-phenyl-3- (trifluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-methyl-5-phenyl-3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-methoxyphenyl) -4-methyl-3- (trifluoromethyl) -1H- pyrazol-1-y1]benzenesulfonamide; 4-[5- (4-chlorophenyl) -4-methyl-3- (trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-chlorophenyl)-4-ethyl-3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[4-ethyl-5-(4-methylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[4-ethyl-5- (4-methoxy-3-methylphenyl) -3- (trifluoromethyl)-lH-pyrazol-1-yl]benzenesulfonamide; 4-[4-ethyl-5- ( -methoxyphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[4-cyclopropyl-5-phenyl-3- (trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4-[4-ethyl-5-(3-fluoro-4-chlorophenyl)-3- (trifluoromethyl) -lH-pyrazol-l-yl]benzenesulfonamide; 4-[4-hydroxymethyl-5-phenyl-3- (trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4-[5-(4-fluorophenyl) -4-methyl-3- (trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[4-methyl-5- (4-methylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[4-fluoro-5-phenyl-3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-bromo-5- (4-chlorophenyl) -3- (difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [4-chloro-5- (3,5-dichloro-4-methoxyphenyl)-3- (difluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4-[4-chloro-3- (difluoromethyl) -5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[4-bromo-3- (difluoromethyl)-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4- [4-chloro-3- (difluoromethyl)-5- (4-methoxyphenyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[4-chloro-3-cyano-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[4-chloro-5- (4-chlorophenyl) -3-cyano-lH-pyrazol-l- y1]benzenesulfonamide; 4- [4-chloro-3-cyano-5- (4-fluorophenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-bromo-3-cyano-5-(4-fluorophenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-bromo-3-cyano-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; ethyl [1-(4-aminosulfonylphenyl) -4-bromo-5- (4- chlorophenyl) -lH-pyrazol-3-yl]carboxylate; methyl [1- (4-aminosulfonylphenyl)-4-chloro-5-phenyl-lH- pyrazol-3-yl]carboxylate; methyl [1- (4-aminosulfonylphenyl)-4-chloro-5- (4- chlorophenyl) -lH-pyrazol-3-yl]carboxylate; ethyl [1-(4-aminosulfonylphenyl)-4-chloro-5-(4- chlorophenyl) -lH-pyrazol-3-yl]carboxylate; methyl [1- (4-aminosulfonylphenyl) -4-chloro-5-(4- fluorophenyl) -lH-pyrazol-3-yl]carboxylate; methyl [1- (4-aminosulfonylphenyl) -4-bromo-5- (4- fluorophenyl) -lH-pyrazol-3-yl]carboxylate; methyl [1- (4-aminosulfonylphenyl) -4-chloro-5- (3-chloro- 4-methoxyphenyl) -lH-pyrazol-3-yl]carboxylate; methyl [1- (4-aminosulfonylphenyl) -4-chloro-5- (3,5- dichloro-4-methoxyphenyl)-lH-pyrazol-3-yl]carboxylate; methyl [1- (4-aminosulfonylphenyl) -5- (3-bromo-4- methoxyphenyl)-4-chloro-lH-pyrazol-3-yl]carboxylate; [1-(4-aminosulfonylphenyl)-4-chloro-5-phenyl-lH-pyrazol- 3-y1]carboxamide; [1-(4-aminosulfonylphenyl)-4-chloro-5-(4-chlorophenyl)- lH-pyrazol-3-yl]carboxamide; [1-(4-aminosulfonylphenyl) -4-chloro-5-(4-fluorophenyl)- lH-pyrazol-3-yl]carboxamide; [1- (4-aminosulfonylphenyl)-4-bromo-5- (4-chlorophenyl)- lH-pyrazol-3-yl]carboxamide; [1-(4-aminosulfonylphenyl)-4-bromo-5-phenyl-lH-pyrazol- 3-yl]carboxamide; [1-(4-aminosulfonylphenyl)-4-chloro-5-(4-chlorophenyl)- lH-pyrazol-3-yl]carboxylic acid; [1- (4-aminosulfonylphenyl)-4-chloro-5-phenyl-lH-pyrazol- 3-yl]carboxylic acid; [1-(4-aminosulfonylphenyl) -4-chloro-5- (3,5-dichloro-4- methoxyphenyl) -lH-pyrazol-3-yl]carboxylic acid; 4-[4-chloro-3-isopropyl-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[4-chloro-3-methyl-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[4-chloro-3-hydroxymethyl-5-phenyl-lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-chloro-5- (4-chlorophenyl) -3-hydroxymethyl-lH- pyrazol-1-yl]benzenesulfonamide; [1- (4-aminosulfonylphenyl)-4-chloro-5- (4-chlorophenyl) -lH-pyrazol-3-yl]propanoic acid; 4-[5- (4-chlorophenyl)-3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-phenyl-3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-fluorophenyl) -3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-cyanophenyl) -3- (trifluoromethyl) -lH-pyrazol-1- y1]benzenesulfonamide; 4-[5- (2,4-difluorophenyl)-3- (trifluoromethyl)-1H- pyrazol-1-y1] enzenesulfonamide; 4-[5- (2,6-difluorophenyl)-3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-methoxyphenyl) -3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (3,4-dichlorophenyl)-3- (trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-bromophenyl) -3- (trifluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (2,4-dichlorophenyl)-3- (trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (3-chlorophenyl)-3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-methylphenyl)-3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-trifluoromethylphenyl)-3-(trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-trifluoromethoxyphenyl) -3-(trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-nitrophenyl)-3-(trifluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (2-chlorophenyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (2-fluorophenyl)-3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (4-aminophenyl)-3- (trifluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (2-methylphenyl)-3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(4-fluoro-2-methylphenyl)-3-(trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (3-methylphenyl) -3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-ethoxyphenyl) -3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (3,5-dimethyl-4-methoxyphenyl) -3-(trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4-[5-(3-fluorophenyl) -3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (3-fluoro-4-methoxyphenyl)-3-(trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-methylthiophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-chloro-3-methylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-ethylphenyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (2,4-dimethylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2-methoxyphenyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (4-methoxy-3-methylphenyl) -3- (trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (3-bromo-4-methylthiophenyl) -3- (trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-hydroxy-3-methylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (3-chloro-4-methylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (3 , 4-dimethoxyphenyl) -3- (trifluoromethyl) -1H- pyrazo1-1-y1]benzenesulfonamide; 4- [5- (3-chloro-4-methoxyphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (3-chloro-4-methoxy-5-methylphenyl) -3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (3-ethyl-4-methoxyphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-fluoro-2-methoxyphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-hydroxymethylphenyl) -3- (trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-methoxy-3- (1-propenyl)phenyl) -3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (3,5-dichloro-4-methoxyphenyl) -3- (trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (2,4-dimethoxyphenyl) -3- (trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (3-chloro-4-fluorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-methoxy-3-propylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (3,5-difluoro-4-methoxyphenyl) -3-(trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4-[5- (3-fluoro-4-methylthiophenyl) -3- (trifluoromethyl)- lH-pyrazol-1-yl]benzenesulfonamide; 4-[5- (3-cyclopropylmethyl-4-methoxyphenyl) -3- (trifluoromethyl)-lH-pyrazol-1-yl]benzenesulfonamide; 4-[1-[4- (aminosulfonyl)phenyl]-3- (trifluoromethyl)-1H- pyrazol-5-yl]benzoic acid; 4-[5- (3-methyl-4-methylthiophenyl)-3-(trifluoromethyl)- lH-pyrazol-1-yl]benzenesulfonamide; 4-[5- (3-chloro-4-methylthiophenyl) -3-(trifluoromethyl)- lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-(N,N-dimethylamino)phenyl) -3- (trifluoromethyl)- lH-pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-methyl-3-nitrophenyl)-3- (trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5-(4- (N-methylamino)phenyl)-3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (3-amino-4-methylphenyl) -3- (trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; methyl-4- [1-[4- (aminosulfonyl)phenyl]-3- (trifluoromethyl) -lH-pyrazol-5-yl]benzoate; 4- [1- [4- (aminosulfonyl)phenyl] -3- (trifluoromethyl) -1H- pyrazol-5-yl]benzamide; 4-[5- (3,5-difluorophenyl)-3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (2,4,6-trifluorophenyl) -3-(trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2, 6-dichlorophenyl)-3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide, • 4-[5-(2,4,6-trichlorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (3-methoxyphenyl) -3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (3,4-dime hylphenyl)-3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (1,3-benzodioxol-5-yl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2-fluoro-4-methoxyphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2-chloro-4-methoxyphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-chloro-2-methoxyphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2-methylthiophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (3-methylthiophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2-methylsulfinylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (3-methylsulfinylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-y1]benzenesulfonamide; 4- [5- (4-methylsulfinylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2-fluoro-4-methylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-fluoro-3-methylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-y1]benzenesulfonamide; 4- [5- (2-chloro-4-methylphenyl)-3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-chloro-2-methylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-y1]benzenesulfonamide; 4- [5- (4-hydroxypheny1) -3- (trifluoromethyl) -lH-pyrazol-1- y1]benzenesulfonamide; 4- [5- (3 , 4-dihydroxyphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-isopropylphenyl) -3- (trifluoromethyl) -lH-pyrazol- 1-y1]benzenesulfonamide; N- [4- [1- [4- (aminosulfonyl)phenyl] -3-trifluoromethyl-lH- pyrazol-5-yl]phenyl]acetamide; N- [4-[1-[4- (aminosulfonyl)phenyl] -3-trifluoromethyl-lH- pyrazol-5-yl]phenyl] formamide; N- [4- [1-[4- (aminosulfonyl)phenyl] -3-trifluoromethy1-1H- pyrazol-5-yl]phenyl] trifluoroacetamide; 4-[5- (4-[N-methylaminosulfonyl]phenyl) -3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (2, 5-dichlorophenyl) -3- (trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-n-butoxyphenyl) -3- (trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (4- [aminosulfonyl] henyl) -3- (trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (2,3-difluorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (2,5-difluorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2, 3, 4-trifluorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (3,4, 5-trifluorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2,4, 5-trifluorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2,5, 6-trifluorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-y1]benzenesulfonamide; 4- [5- (2,3,4,5-tetrafluorophenyl)-3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2,3, 4, 6-tetrafluorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2,3, 5, 6-tetrafluorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (pentafluorophenyl) -3- (trifluoromethyl) -lH-pyrazol- 1-y1]benzenesulfonamide; 4- [5- (2,3, 4-trichlorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (3,4,5-trichlorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2, 4, 5-trichlorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2, 5, 6-trichlorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-y1]benzenesulfonamide; 4-[5- (2,3, 4,5-tetrachlorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2,3,4, 6-tetrachlorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2, 3 , 5, 6-tetrachlorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5-(2,3,4,5, 6-pentachlorophenyl) -3- (trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-tert-butylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-isobutylphenyl) -3- (trifluoromethyl) -lH-pyrazol- 1-yl]benzenesulfonamide; 4- [5- (4-chlorophenyl) -3- (difluorome hyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-trifluoromethylphenyl) -3- (difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-methylthiophenyl) -3- (difluoromethyl) -lH-pyrazol- 1-yl]benzenesulfonamide; 4- [5- (4- (1-morpholino)phenyl) -3- (difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-methylphenyl) -3- (difluoromethyl) -IH-pyrazol-l- yl]benzenesulfonamide; 4- [5-phenyl-3- (difluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (4-methoxyphenyl) -3- (difluoromethyl) -lH-pyrazol-1- y1]benzenesulfonamide; 4- [5- (3, 4-dimethylphenyl) -3- (difluoromethyl) -lH-pyrazol- 1-yl]benzenesulfonamide; 4- [5- (3-fluoro-4-methoxyphenyl) -3- (difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [1- [4- (aminosulfonyl)phenyl] -3- (difluoromethyl) -1H- pyrazol-5-yl]benzoic acid; methyl 4- [1- [4- (aminosulfonyl)phenyl] -3- (difluoromethyl) -lH-pyrazol-5-yl]benzoate; 4-[l- (4-aminosulfonylphenyl) -3- (difluoromethyl) - lH-pyrazol-5-yl]benzamide; 4- [5- (2-fluoro-4-methoxyphenyl) -3- (difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-cyanophenyl) -3- (difluoromethyl) -lH-pyrazol-1- y1]benzenesulfonamide; 4-[5-(3-chloro-4-methylphenyl) -3- (difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (3-chloro-4-methoxyphenyl) -3- (difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-chloro-3-methylphenyl) -3-(difluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (3,4-dimethoxyphenyl)-3- (difluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5-(3,5-dichloro-4-methoxyphenyl) -3-(difluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4-[5-(3,5-difluoro-4-methoxyphenyl) -3-(difluoromethyl) - lH-pyrazo1-1-yl]benzenesulfonamide; 4-[5- (2-methoxyphenyl) -3-(difluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (3-bromo-4-me hoxyphenyl) -3- (difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-methylsulfonylphenyl) -3- (difluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (5-bromo-2-thienyl)-3-(difluoromethyl) -lH-pyrazol- 1-yl]benzenesulfonamide; 4-[5- (5-chloro-2-thienyl)-3- (difluoromethyl) -lH-pyrazol- 1-y1]benzenesulfonamide; 4-[5- (1-cyclohexenyl) -3-(difluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (cyclohexyl) -3- (difluoromethyl) -IH-pyrazol-l- yl]benzenesulfonamide; 4-[5- (biphenyl) -3- (difluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (1,4-benzodioxan-6-yl)-3-(difluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[3- (difluoromethyl) -5-(4-methylcyclohexyl)-lH-pyrazol- 1-yl]benzenesulfonamide; 4-[5-(methyl-1-cyclohexenyl) -3- (difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (2-methyl-l-cyclopentenyl) -3- (difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (benzofuran-2-yl) -3- (difluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(l,3-benzodioxol-5-yl)-3-(difluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (2-pyrazinyl) -3-(difluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-(morpholino)phenyl)-3-(difluoromethyl)-1H- pyrazol-1-y1]benzenesulfonamide; 4-[5-(2,5-dimethyl-3-furyl)-3-(difluoromethyl)-lH- pyrazol-1-yl]benzenesulfonamide; 4-[5-(5-methyl-2-furyl) -3-(difluoromethyl) -lH-pyrazol- 1-yl]benzenesulfonamide; 4-[5-(l-chloro-l-methyl-4-cyclohexyl)-3- (difluoromethyl) -lH-pyrazol-1-y1]benzenesulfonamide; 4-[5-(3,4-dibromo-4-methylcyclohexyl)-3- (difluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4-[5-(2-methoxycyclohexyl)-3-(difluoromethyl)-1H- pyrazol-1-y1]benzenesulfonamide; 4-[5-(2-thienyl) -3-(difluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(2,4-dimethyl-3-thienyl)-3-(difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5-(2,5-dichloro-3-thienyl)-3-(difluoromethyl)-lH- pyrazol-1-yl]benzenesulfonamide; 4-[5-(benzofuran-5-yl) -3-(trifluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(5-bromo-2-thienyl)-3-(trifluoromethyl) -lH-pyrazol- 1-yl]benzenesulfonamide; 4-[5-(5-chloro-2-thienyl)-3- (trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5-(5-indanyl) -3-(trifluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(5-methyl-2-thienyl)-3-(trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5-(2,3-dihydrobenzofuran-5-yl)-3- (trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4-[5-(1-cyclohexenyl)-3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(5-benzothienyl)-3-(trifluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4- [ 5 - (3 , 4-dihydro-2H-l-benzopyran-6-yl ) -3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (3, 4-dihydro-2H-l-benzothiopyran-6-yl) -3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (2-phenylethenyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl] enzenesulfonamide; 4- [5- ( -methyl-1, 3-benzodioxol-6-yl) -3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-methyl-l,3-benzodioxol-5-yl) -3- (trifluoromethyl) -IH-pyrazol-l-yl]benzenesulfonamide; 4- [5- (2-pyrazinyl) -3- (trifluoromethyl) -lH-pyrazol-1- y1]benzenesulfonamide; 4- [5- (biphenyl) -3- (trifluoromethyl) -lH-pyrazol-1- y1]benzenesulfonamide; 4-[5-(l,2,3,4-tetrahydronaphth-6-yl] )-3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (2-naphthyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (2-thiazolyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (2-oxazolyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (cyclohexyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (cyclopentyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (cycloheptyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (1-cyclopentenyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (2-furyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (2-pyridyl) -3- (trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4-[5-(3-pyridyl) -3- (trifluoromethyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4- [5- (6-methyl-3-pyridyl) -3- (trifluoromethyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4-[5- (4-pyridyl)-3- (trifluoromethyl)- IH-pyrazol-l-yl]benzenesulfonamide; 4-[5-(3-cyclohexenyl) -3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-cyclohexenyl)-3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(4-methylcyclohex-4-ene-l-yl)-3-(trifluoromethyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4-[5- (5-chloro-2-furyl) -3-(trifluoromethyl) -lH-pyrazol- 1-yl]benzenesulfonamide; 4-[5- (5-bromo-2-furyl) -3- (trifluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (6-methoxy-2-naphthyl)-3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-chlorophenyl) -3-(heptafluoropropyl) -lH-pyrazol- 1-y1]benzenesulfonamide; 4-[5- (4-chlorophenyl) -3-(chlorodifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-chlorophenyl)-3-(pentafluoroethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(3-chloro-4-methoxyphenyl) -3-(chloromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [3- (chlorodifluoromethyl) -5- (3-fluoro-4- methoxyphenyl) -IH-pyrazol-l-yl]benzenesulfonamide; 4-[5- (phenyl) -3- (fluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[3- (dichloromethyl) -5-(3-fluoro-4-methoxyphenyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[3-(bromodifluoromethyl) -5-(3-fluoro-4-methoxyphenyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4-[5-(4-chlorophenyl) -3-(fluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-chlorophenyl)-3-(chloromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(4-chlorophenyl) -3-(dichloromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(4-chlorophenyl) -3- (dichlorofluoromethyl) -1H- pyrazol-1-yl]benzene sulfonamide; 4-[5- (4-fluorophenyl) -3-(trichloromethyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4-[5- (4-chlorophenyl)-3- (1,1-difluoroethyl)-lH-pyrazol- 1-y1]benzenesulfonamide; 4-[5-(4-chlorophenyl)-3-(1,1-difluoropropyl) -lH-pyrazol- 1-yl]benzenesulfonamide; 4-[5- (4-chlorophenyl) -3- (1,1-dichloroethyl) -lH-pyrazol- 1-y1]benzenesulfonamide; 4- [5- (4-chlorophenyl) -3- (1,1-dichloropropyl) -lH-pyrazol- 1-yl]benzenesulfonamide; 4-[5- (4-chlorophenyl) -3-nitro-lH-pyrazol-l- yl]benzenesulfonamide; 4-[5- (4-chlorophenyl)-3-(amidino) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(4-chlorophenyl) -3-(methylsulfonyl) -lH-pyrazol-1- y1]benzenesulfonamide; 4-[5- (4-chlorophenyl) -3- ( -me hy1-aminosulfonyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5-(4-fluorophenyl) -3-(imidazolyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4-[5- (4-fluorophenyl) -3- (2-pyridyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4-[5- (4-chlorophenyl)-3- (N-cyanoamidino) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-chlorophenyl) -3- (tetrazolyl) -lH-pyrazol-1- y1]benzenesulfonamide; 4-[5- (4-chlorophenyl) -3- (phenylsulfonyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-chlorophenyl) -3-(N-phenylaminosulfonyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5-(4-chlorophenyl)-3- (N,N-dimethylaminosulfonyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5-(4-chlorophenyl) -3-(N-methyl-N- phenylaminosulfonyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(4-chlorophenyl) -3-(N-ethylaminosulfonyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-chlorophenyl) -3- (N-isopropylaminosulfonyl) -1H- pyrazol-1-y1]benzenesulfonamide; 4-[5- (4-chlorophenyl) -3-(N-methyl-N-ethylaminosulfonyl)- IH-pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-chlorophenyl) -3- (N-methyl-N- (3-chlorophenyl) aminosulfonyl)-IH-pyrazol-l-yl]benzenesulfonamide; 4-[5- (4-chlorophenyl) -3-(N-methyl-N- (2-pyridyl) aminosulfonyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4-[3-methyl-5-phenyl-IH-pyrazol-1-y1]benzenesulfonamide; 4-[3-isobutyl-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[3- (3-hydroxypropyl) -5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[5- (4-fluorophenyl) -3- (3-hydroxypropyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4-[5- (3,5-dichloro-4-methoxyphenyl) -3- (3-hydroxypropyl)- IH-pyrazol-l-yl]benzenesulfonamide; 4-[5- (4-me hylphenyl)-3- (2-hydroxyisopropyl) - IH-pyrazol-l-yl]benzenesulfonamide; 1-[4- (aminosulfonyl)phenyl] -5- (4-fluorophenyl) - lH-pyrazole-3-propanoic acid; 1-[4- (aminosulfonyl)phenyl] -5- (4-chlorophenyl)- lH-pyrazole-3-propanoic acid; l-[4- (aminosulfonyl)phenyl] -5- (4-chlorophenyl) -1H- pyrazole-3-propanamide; methyl 1-[4- (aminosulfonyl)phenyl] -5- (4-fluorophenyl) - lH-pyrazole-3-propanoate; 4-[3-(3-hydroxymethyl) -5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[5- (4-chlorophenyl) -3- (3-hydroxymethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[3- (3-hydroxymethyl) -5- (4-methoxyphenyl) -lH-pyrazol-1- y1]benzenesulfonamide; 4-[5-(3,5-dichloro-4-methoxyphenyl) -3- (3-hydroxymethyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4-[5-(3-chloro-4-methoxyphenyl)-3- (3-hydroxymethyl)-1H- pyrazol-1-yl]benzenesulfonamide; ethyl 3-[1- (4-aminosulfonylphenyl) -5- (phenyl)-1H- pyrazol-3-yl] -2-cyano-2-propenoate; 4-[5- (4-chlorophenyl)-3- (chloro)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(4-chlorophenyl) -3-(bromo) -lH-pyrazol-1- y1]benzenesulfonamide; 4-[5- (4-chlorophenyl) -3- (fluoro) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [3- (difluoromethyl)-4,5-dihydro-7-methoxy-lH- benz[g]indazol-1-yl]benzenesulfonamide; 4-[3- (difluoromethyl) -4,5-dihydro-7-methyl-lH- benz[g]indazol-1-yl]benzenesulfonamide,- 4-[4,5-dihydro-7-methoxy-3- (trifluoromethyl)-1H- benz[g]indazol-1-yl]benzenesulfonamide; 4-[4,5-dihydro-3- (trifluoromethyl) -IH-benz[g]indazol-1- yl]benzenesulfonamide; 4-[4,5-dihydro-7-methyl-3- (trifluoromethyl) -1H- benz[g]indazol-1-yl]benzenesulfonamide; 4-[4,5-dihydro-6,8-dimethyl-3- (trifluoromethyl) -1H- benz[g]indazol-1-yl]benzenesulfonamide; 4-[4,5-dihydro-6,8-dimethoxy-3- (trifluoromethyl) -IH- benz[g]indazol-1-yl]benzenesulfonamide; methyl[1-(4-aminosulfonylphenyl)-4,5-dihydro-7-methoxy- lH-benz[g]indazol-3-yl]carboxylate; 4-[4,5-dihydro-3-trifluoromethyl-lH- thieno[3,2,g]indazol-1-yl] enzenesulfonamide; 4-[l-phenyl-3- (difluoromethyl) -lH-pyrazol-5- yl]benzenesulfonamide; 4-[1- (4-chlorophenyl) -3-(difluoromethyl)-lH-pyrazol-5- yl]benzenesulfonamide; 4-[1-(4-fluorophenyl) -3- (difluoromethyl) -lH-pyrazol-5- yl]benzenesulfonamide; 4-[1-(4-methoxyphenyl) -3-(difluoromethyl) -lH-pyrazol-5- yl]benzenesulfonamide; 4-[l-phenyl-3- (trifluoromethyl) -lH-pyrazol-5- yl]benzenesulfonamide; 4-[l- (4-chlorophenyl) -3-(trifluoromethyl) -lH-pyrazol-5- yl]benzenesulfonamide; 4-[1- (4-fluorophenyl) -3-(trifluoromethyl) -lH-pyrazol-5- yl] enzenesulfonamide; and 4-[1- (4-methoxyphenyl) -3-(trifluoromethyl)-lH-pyrazol-5- yl]benzenesulfonamide. A family of specific compounds of particular interest within Formula II consists of compounds and pharmaceutically-acceptable salts thereof as follows: 4-[5- (4-chlorophenyl) -3- (trifluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-phenyl-3- (trifluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-fluorophenyl) -3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-methoxyphenyl) -3-(trifluoromethyl)-lH-pyrazol-1- yl3benzenesulfonamide; 4-[5- (4-chlorophenyl) -3-(difluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(4-methylphenyl) -3-(trifluoromethyl) -lH-pyrazol-1- y1]benzenesulfonamide; 4-[4-chloro-5- (4-chlorophenyl) -3- (trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[3- (difluoromethyl)-5- (4-methylphenyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[3- (difluoromethyl)-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[3- (difluoromethyl)-5-(4-methoxyphenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[3-cyano-5- (4-fluorophenyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[3-(difluoromethyl) -5-(3-fluoro-4-methoxyphenyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (3-fluoro-4-methoxyphenyl)-3- (trifluoromethyl)-1H- pyrazol-1-y1]benzenesulfonamide; 4-[4-chloro-5-phenyl-lH-pyrazol-l-yl]benzenesulfonamide; 4-[5- (4-chlorophenyl) -3-(hydroxymethyl) -lH-pyrazol-1- yl]benzenesulfonamide; and 4-[5- (4- (N,N-dimethylamino)phenyl) -3- (trifluoromethyl) - IH-pyrazol-l-yl]benzenesulfonamide. The term "hydrido" denotes a single hydrogen atom (H) . This hydrido radical may be attached, for example, to an oxygen atom to form a hydroxyl radical or two hydrido radicals may be attached to a carbon atom to form a methylene (-CH2-) radical. Where the term "alkyl" is used, either alone or within other terms such as "haloalkyl" and "alkylsulfonyl", it embraces linear or branched radicals having one to about twenty carbon atoms or, preferably, one to about twelve carbon atoms. More preferred alkyl radicals are "lower alkyl" radicals having one to about ten carbon atoms. Most preferred are lower alkyl radicals having one to about six carbon atoms. Examples of such radicals include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec- butyl, tert-butyl, pentyl, iso-amyl, hexyl and the like. The term "alkenyl" embraces linear or branched radicals having at least one carbon-carbon double bond of two to about twenty carbon atoms or, preferably, two to about twelve carbon atoms. More preferred alkyl radicals are "lower alkenyl" radicals having two to about six carbon atoms. Examples of such radicals include ethenyl, n-propenyl, butenyl, and the like. The term "halo" means halogens such as fluorine, chlorine, bromine or iodine atoms. The term "haloalkyl" embraces radicals wherein any one or more of the alkyl carbon atoms is substituted with halo as defined above. Specifically embraced are monohaloalkyl, dihaloalkyl and polyhaloalkyl radicals. A monohaloalkyl radical, for one example, may have either an iodo, bromo, chloro or fluoro atom within the radical. Dihalo and polyhaloalkyl radicals may have two or more of the same halo atoms or a combination of different halo radicals. "Lower haloalkyl" embraces radicals having 1- 6 carbon atoms. Examples of haloalkyl radicals include fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl and dichloropropyl. The term "hydroxyalkyl" embraces linear or branched alkyl radicals having one to about ten carbon atoms any one of which may be substituted with one or more hydroxyl radicals. More preferred hydroxyalkyl radicals are "lower hydroxyalkyl" radicals having one to six carbon atoms and one or more hydroxyl radicals. Examples of such radicals include hydroxymethyl, hydroxyethyl, hydroxypropyl, hydroxybutyl and hydroxyhexyl. The terms "alkoxy" and "alkoxyalkyl" embrace linear or branched oxy-containing radicals each having alkyl portions of one to about ten carbon atoms, such as methoxy radical. More preferred alkoxy radicals are "lower alkoxy" radicals having one to six carbon atoms. Examples of such radicals include methoxy, ethoxy, propoxy, butoxy and tert-butoxy. The term "alkoxyalkyl" also embraces alkyl radicals having two or more alkoxy radicals attached to the alkyl radical, that is, to form monoalkoxyalkyl and dialkoxyalkyl radicals. More preferred alkoxyalkyl radicals are "lower alkoxyalkyl" radicals having one to six carbon atoms and one or two alkoxy radicals. Examples of such radicals include methoxymethyl, methoxyethyl, ethoxyethyl, methoxybutyl and methoxypropyl. The "alkoxy" or "alkoxyalkyl" radicals may be further substituted with one or more halo atoms, such as fluoro, chloro or bromo, to provide "haloalkoxy" or "haloalkoxyalkyl" radicals. Examples of such radicals include fluoromethoxy, chloromethoxy, trifluoromethoxy, trifluoroethoxy, fluoroethoxy and fluoropropoxy. The term "aryl", alone or in combination, means a carbocyclic aromatic system containing one, two or three rings wherein such rings may be attached together in a pendent manner or may be fused. The term "aryl" embraces aromatic radicals such as phenyl, naphthyl, tetrahydronaphthyl, indane and biphenyl. The term "heterocyclic" embraces saturated, partially saturated and unsaturated heteroatom-containing ring-shaped radicals, where the heteroatoms may be selected from nitrogen, sulfur and oxygen. Examples of saturated heterocyclic radicals include saturated 3 to 6-membered heteromonocylic group containing 1 to 4 nitrogen atoms[e.g. pyrrolidinyl, imidazolidinyl, piperidino, piperazinyl, etc.]; saturated 3 to 6-membered heteromonocyclic group containing 1 to 2 oxygen atoms and 1 to 3 nitrogen atoms [e.g. morpholinyl, etc.]; saturated 3 to 6-membered heteromonocyclic group containing 1 to 2 sulfur atoms and 1 to 3 nitrogen atoms [e.g., thiazolidinyl, etc.]. Examples of partially saturated heterocyclic radicals include dihydrothiophene, dihydropyran, dihydrofuran and dihydrothiazole. The term "heteroaryl" embraces unsaturated heterocyclic radicals. Examples of unsaturated heterocyclic radicals, also termed "heteroaryl" radicals include unsaturated 5 to 6 membered heteromonocyclic group containing 1 to 4 nitrogen atoms, for example, pyrrolyl, pyrrolinyl, imidazolyl, pyrazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, triazolyl [e.g., 4H-1,2,4- triazolyl, 1H-1, 2,3-triazolyl, 2H-1,2,3-triazolyl, etc.] tetrazolyl [e.g. lH-tetrazolyl, 2H-tetrazolyl, etc.], etc.; unsaturated condensed heterocyclic group containing 1 to 5 nitrogen atoms, for example, indolyl, isoindolyl, indolizinyl, benzimidazolyl, quinolyl, isoquinolyl, indazolyl, benzotriazolyl, tetrazolopyridazinyl [e.g., tetrazolo [1,5-b]pyridazinyl, etc.], etc.; unsaturated 3 to 6-membered heteromonocyclic group containing an oxygen atom, for example, pyranyl, 2-furyl, 3-furyl, etc.; unsaturated 5 to 6-membered heteromonocyclic group containing a sulfur atom, for example, 2-thienyl, 3-thienyl, etc.; unsaturated 5- to 6-membered heteromonocyclic group containing 1 to 2 oxygen atoms and 1 to 3 nitrogen atoms, for example, oxazolyl, isoxazolyl, oxadiazolyl [e.g., 1,2,4-oxadiazolyl, 1,3,4- oxadiazolyl, 1,2,5-oxadiazolyl, etc.] etc.; unsaturated condensed heterocyclic group containing 1 to 2 oxygen atoms and 1 to 3 nitrogen atoms [e.g. benzoxazolyl, benzoxadiazolyl, etc.]; unsaturated 5 to 6-membered heteromonocyclic group containing 1 to 2 sulfur atoms and 1 to 3 nitrogen atoms, for example, thiazolyl, thiadiazolyl [e.g., 1,2,4- thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,5- thiadiazolyl, etc.] etc.; unsaturated condensed heterocyclic group containing 1 to 2 sulfur atoms and 1 to 3 nitrogen atoms [e.g., benzothiazolyl, benzothiadiazolyl, etc.] and the like. The term also embraces radicals where heterocyclic radicals are fused with aryl radicals. Examples of such fused bicyclic radicals include benzofuran, benzothiophene, and the like. Said "heterocyclic group" may have 1 to 3 substituents such as lower alkyl, hydroxy, oxo, amino and lower alkylamino. Preferred heterocyclic radicals include five to ten membered fused or unfused radicals. More preferred examples of heteroaryl radicals include benzofuryl, 2,3- dihydrobenzofuryl, benzothienyl, indolyl, dihydroindolyl, chromanyl, benzopyran, thiochromanyl, benzothiopyran, benzodioxolyl, benzodioxanyl, pyridyl, thienyl, thiazolyl, oxazolyl, furyl, and pyrazinyl. The term "sulfonyl", whether used alone or linked to other terms such as alkylsulfonyl, denotes respectively divalent radicals -SO2-. "Alkylsulfonyl" embraces alkyl radicals attached to a sulfonyl radical, where alkyl is defined as above. More preferred alkylsulfonyl radicals are "lower alkylsulfonyl" radicals having one to six carbon atoms. Examples of such lower alkylsulfonyl radicals include methylsulfonyl, ethylsulfonyl and propylsulfonyl. The term "arylsulfonyl" embraces aryl radicals as defined above, attached to a sulfonyl radical. Examples of such radicals include phenylsulfonyl. The terms "sulfamyl," "aminosulfonyl" and "sulfonamidyl, " whether alone or used with terms such as "N- alkylaminosulfonyl", "N-arylaminosulfonyl", "N,N- dialkylaminosulfonyl" and "N-alkyl-N-arylaminosulfonyl", denotes a sulfonyl radical substituted with an amine radical, forming a sulfonamide (-SO2NH2) . The terms "N- alkylaminosulfonyl" and "N,N-dialkylaminosulfonyl" denote sulfamyl radicals substituted, respectively, with one alkyl radical, or two alkyl radicals. More preferred alkylaminosulfonyl radicals are "lower alkylaminosulfonyl" radicals having one to six carbon atoms. Examples of such lower alkylaminosulfonyl radicals include N- methylaminosulfonyl, N-ethylaminosulfonyl and N-methyl-N- ethyla inosulfonyl. The terms "N-arylaminosulfonyl" and "N- alkyl-N-arylaminosulfonyl" denote sulfamyl radicals substituted, respectively, with one aryl radical, or one alkyl and one aryl radical. More preferred N-alkyl-N- arylaminosulfonyl radicals are "lower N-alkyl-N-arylsulfonyl" radicals having alkyl radicals of one to six carbon atoms. Examples of such lower N-alkyl-N-aryl aminosulfonyl radicals include N-methyl-phenylaminosulfonyl and N-ethyl- phenylaminosulfonyl The terms "carboxy" or "carboxyl", whether used alone or with other terms, such as "carboxyalkyl", denotes -C02H. The terms "alkanoyl" or "carboxyalkyl" embrace radicals having a carboxy radical as defined above, attached to an alkyl radical. The alkanoyl radicals may be substituted or unsubstituted, such as formyl, acetyl, propionyl (propanoyl), butanoyl (butyryl), isobutanoyl (isobutyryl) , valeryl (pentanoyl) , isovaleryl, pivaloyl, hexanoyl or the like. The term "carbonyl", whether used alone or with other terms, such as "alkylcarbonyl" , denotes -(C=0)-. The term "alkylcarbonyl" embraces radicals having a carbonyl radical substituted with an alkyl radical. More preferred alkylcarbonyl radicals are "lower alkylcarbonyl" radicals having one to six carbon atoms. Examples of such radicals include methylcarbonyl and ethylcarbonyl. The term "alkylcarbonylalkyl" , denotes an alkyl radical substituted with an "alkylcarbonyl" radical. The term "alkoxycarbonyl" means a radical containing an alkoxy radical, as defined above, attached via an oxygen atom to a carbonyl radical. Preferably, "lower alkoxycarbonyl" embraces alkoxy radicals having one to six carbon atoms. Examples of such "lower alkoxycarbonyl" ester radicals include substituted or unsubstituted methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, butoxycarbonyl and hexyloxycarbonyl. The term "alkoxycarbonylalkyl" embraces radicals having "alkoxycarbonyl", as defined above substituted to an alkyl radical. More preferred alkoxycarbonylalkyl radicals are "lower alkoxycarbonylalkyl" having lower alkoxycarbonyl radicals as defined above attached to one to six carbon atoms. Examples of such lower alkoxycarbonylalkyl radicals include methoxycarbonylmethyl, tert-butoxycarbonylethyl, and methoxycarbonylethyl. The term "aminocarbonyl" when used by itself or with other terms such as "aminocarbonylalkyl" , "N-alkylaminocarbonyl" , "N- arylaminocarbonyl", "N,N-dialkylaminocarbonyl" , "N-alkyl-N- arylaminocarbonyl" , "N-alkyl-N-hydroxyaminocarbonyl" and "N- alkyl-N-hydroxyaminocarbonylalkyl" , denotes an amide group of the formula -C(=0)NH2* The terms "N-alkylaminocarbonyl" and "N,N-dialkylaminocarbonyl" denote aminocarbonyl radicals which have been substituted with one alkyl radical and with two alkyl radicals, respectively. More preferred are "lower alkylaminocarbonyl" having lower alkyl radicals as described above attached to an aminocarbonyl radical. The terms "N- arylaminocarbonyl" and "N-alkyl-N-arylaminocarbonyl" denote aminocarbonyl radicals substituted, respectively, with one aryl radical, or one alkyl and one aryl radical. The term "aminocarbonylalkyl" embraces alkyl radicals substituted with aminocarbonyl radicals. The term "N-cycloalkylaminocarbonyl" denoted aminocarbonyl radicals which have been substituted with at least one cycloalkyl radical. More preferred are "lower cycloalkylaminocarbonyl" having lower cycloalkyl radicals of three to seven carbon atoms, attached to an aminocarbonyl radical. The term "aminoalkyl" embraces alkyl radicals substituted with amino radicals. The term "alkylaminoalkyl" embraces aminoalkyl radicals having the nitrogen atom substituted with an alkyl radical . The term "amidino" denotes an -C(=NH)-NH2 radical. The term "cyanoamidino" denotes an -C (=N-CN) -NH2 radical. The term "heterocyclicalkyl" embraces heterocyclic-substituted alkyl radicals. More preferred heterocyclicalkyl radicals are "lower heterocyclicalkyl" radicals having one to six carbon atoms and a heterocyclic radical. Examples include such radicals as pyrrolidinyImethyl, pyridyImethyl and thienyImethyl. The term "aralkyl" embraces aryl-substituted alkyl radicals. Preferable aralkyl radicals are "lower aralkyl" radicals having aryl radicals attached to alkyl radicals having one to six carbon atoms. Examples of such radicals include benzyl, diphenyImethyl, triphenylmethyl, phenylethyl and diphenylethy1. The aryl in said aralkyl may be additionally substituted with halo, alkyl, alkoxy, halkoalkyl and haloalkoxy. The terms benzyl and phenylmethyl are interchangeable. The term "cycloalkyl" embraces radicals having three to ten carbon atoms. More preferred cycloalkyl radicals are "lower cycloalkyl" radicals having three to seven carbon atoms. Examples include radicals such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl. The term "cycloalkenyl" embraces unsaturated cyclic radicals having three to ten carbon atoms, such as cyclobutenyl, cyclopentenyl, cyclohexenyl and cycloheptenyl. The term "alkylthio" embraces radicals containing a linear or branched alkyl radical, of one to ten carbon atoms, attached to a divalent sulfur atom. An example of "alkylthio" is methylthio, (CH3-S-) . The term "alkylsulfinyl" embraces radicals containing a linear or branched alkyl radical, of one to ten carbon atoms, attached to a divalent -S(=0)- atom. The term "aminoalkyl" embraces alkyl radicals substituted with amino radicals. More preferred aminoalkyl radicals are "lower aminoalkyl" having one to six carbon atoms. Examples include aminomethyl, aminoethyl and aminobutyl. The term "alkylaminoalkyl" embraces aminoalkyl radicals having the nitrogen atom substituted with at least one alkyl radical. More preferred alkylaminoalkyl radicals are "lower alkylaminoalkyl" having one to six carbon atoms attached to a lower aminoalkyl radical as described above. The terms "N-alkylamino" and "N,N-dialkylamino" denote amino groups which have been substituted with one alkyl radical and with two alkyl radicals, respectively. More preferred alkylamino radicals are "lower alkylamino" radicals having one or two alkyl radicals of one to six carbon atoms, attached to a nitrogen atom. Suitable "alkylamino" may be mono or dialkylamino such as N-methylamino, N-ethylamino, N,N-dimethylamino, N,N-diethylamino or the like. The term "arylamino" denotes amino groups which have been substituted with one or two aryl radicals, such as N-phenylamino. The "arylamino" radicals may be further substituted on the aryl ring portion of the radical. The term "aralkylamino" denotes amino groups which have been substituted with one or two aralkyl radicals, such as N-benzylamino. The "aralkylamino" radicals may be further substituted on the aryl ring portion of the radical. The terms "N-alkyl-N-arylamino" and "N- aralkyl-N-alkylamino" denote amino groups which have been substituted with one aralkyl and one alkyl radical, or one aryl and one alkyl radical, respectively, to an amino group. The terms "N-arylaminoalkyl" and "N-aralkylaminoalkyl" denote amino groups which have been substituted with one aryl radical or one aralkyl radical, respectively, and having the amino group attached to an alkyl radical. More preferred arylaminoalkyl radicals are "lower arylaminoalkyl" having the arylamino radical attached to one to six carbon atoms. Examples of such radicals include N-phenylaminomethyl and N- pheny1-N-methylaminomethyl. The terms "N-alkyl-N- arylaminoalkyl" and "N-aralkyl-N-alkylaminoalkyl" denote N- alkyl-N-arylamino and N-alkyl-N-aralkylamino groups, respectively, and having the amino group attached to alkyl radicals. The term "acyl", whether used alone, or within a term such as "acylamino", denotes a radical provided by the residue after removal of hydroxyl from an organic acid. The term "acylamino" embraces an amino radical substituted with an acyl group. An examples of an "acylamino" radical is acetylamino or acetamido (CH3C(=0) -NH-) where the amine may be further substituted with alkyl, aryl or aralkyl. The term "arylthio" embraces aryl radicals of six to ten carbon atoms, attached to a divalent sulfur atom. An example of "arylthio" is phenylthio. The term "aralkylthio" embraces aralkyl radicals as described above, attached to a divalent sulfur atom. An example of "aralkylthio" is benzylthio. The term "aryloxy" embraces aryl radicals, as defined above, attached to an oxygen atom. Examples of such radicals include phenoxy. The term "aralkoxy" embraces oxy-containing aralkyl radicals attached through an oxygen atom to other radicals. More preferred aralkoxy radicals are "lower aralkoxy" radicals having phenyl radicals attached to lower alkoxy radical as described above. The term "haloaralkyl" embraces aryl radicals as defined above attached to haloalkyl radicals. The term "carboxyhaloalkyl" embraces carboxyalkyl radicals as defined above having halo radicals attached to the alkyl portion. The term "alkoxycarbonylhaloalkyl" embraces alkoxycarbonyl radicals as defined above substituted on a haloalkyl radical. The term "aminocarbonylhaloalkyl" embraces aminocarbonyl radicals as defined above substituted on a haloalkyl radical. The term "alkylaminocarbonylhaloalkyl" embraces alkylaminocarbonyl radicals as defined above substituted on a haloalkyl radical. The term "alkoxycarbonylcyanoalkenyl" embraces alkoxycarbonyl radicals as defined above, and a cyano radical, both substituted on an alkenyl radical. The term "carboxyalkylaminocarbonyl" embraces aminocarbonyl radicals substituted with carboxyalkyl radicals, as defined above. The term "aralkoxycarbonylalkylaminocarbonyl" embraces aminocarbonyl radicals substituted with aryl-substituted alkoxycarbonyl radicals, as defined above. The term "cycloalkylalkyl" embraces cycloalkyl radicals having three to ten carbon atoms attached to an alkyl radical, as defined above. More preferred cycloalkylalkyl radicals are "lower cycloalkylalkyl" radicals having cycloalkyl radicals attached to lower alkyl radicals as defined above. Examples include radicals such as cyclopropyImethyl, cyclobutylmethyl, and cyclohexylethyl. The term "aralkenyl" embraces aryl radicals attached to alkenyl radicals having two to ten carbon atoms, such as phenylbutenyl, and phenylethenyl or styryl. Also included in the family of compounds of Formula I are the pharmaceutically-acceptable salts thereof. The term "pharmaceutically-acceptable salts" embraces salts commonly used to form alkali metal salts and to form addition salts of free acids or free bases. The nature of the salt is not critical, provided that it is pharmaceutically-acceptable. Suitable pharmaceutically-acceptable acid addition salts of compounds of Formula I may be prepared from an inorganic acid or from an organic acid. Examples of such inorganic acids are hydrochloric, hydrobromic, hydroiodic, nitric, carbonic, sulfuric and phosphoric acid. Appropriate organic acids may be selected from aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic, carboxylic and sulfonic classes of organic acids, example of which are formic, acetic, propionic, succinic, glycolic, gluconic, lactic, malic, tartaric, citric, ascorbic, glucuronic, maleic, fumaric, pyruvic, aspartic, glutamic, benzoic, anthranilic, mesylic, salicyclic, salicyclic, 4- hydroxybenzoic, phenylacetic, mandelic, embonic (pamoic), methanesulfonic, ethanesulfonic, benzenesulfonic, pantothenic, 2-hydroxyethanesulfonic, toluenesulfonic, sulfanilic, cyclohexylaminosulfonic, stearic, algenic, β- hydroxybutyric, salicyclic, galactaric and galacturonic acid. Suitable pharmaceutically-acceptable base addition salts of compounds of Formula I include metallic salts made from aluminum, calcium, lithium, magnesium, potassium, sodium and zinc or organic salts made from N,N'- dibenzylethylenediamine, chloroprocaine, choline, diethanolamine, ethylenediamine, meglumine (N- methylglucamine) and procaine. All of these salts may be prepared by conventional means from the corresponding compound of Formula I by reacting, for example, the appropriate acid or base with the compound of Formula I. GENERAL SYNTHETIC PROCEDURES The compounds of the invention can be synthesized according to the following procedures of Schemes I-VIII, wherein the R 1 -R 7 substituents are as defined for Formula I, above, except where further noted. 97/11704 60 SCHEME I 3 R 2 , I' Base, -78°C 0 R 4 —CCH 3 -==-^ ■*- II Base t R 3 χ R 4 - CCH 2 R3 THF acylat ion R C 4-R 1 NHNH 2 Alcohol , Δ Synthetic Scheme I shows the preparation of tetrasubstituted pyrazoles from starting material 1. In step 1 of synthetic Scheme I, the phenyl-methyl ketone (1) is treated with a base and an alkylating reagent (R-^X, where X represents a leaving group such as tosyl) to give the substituted ketone (2). In step 2, the substituted ketone (2) is treated with base, such as sodium methoxide, and an acylating reagent such as an ester (R C0 2 CH 3 ) , or ester equivalent (R CO-imidazole, to give the intermediate diketone (3) in a procedure similar to that developed by Reid and Calvin, J. Amer. Chem . Soc , 72, 2948-2952 (1950). In step 3, the diketone (3) is reacted with a substituted hydrazine in acetic acid or an alcoholic solvent to give a mixture of pyrazoles (4) and (5) . Separation of the desired pyrazole (4) can be achieved by chromatography or recrystallization. SCHEME II 6 Synthetic Scheme II shows the preparation of compounds embraced by Formula I, where R3 is a hydrogen atom. In step 1, ketone (1) is treated with a base, preferably NaOMe or NaH, and an ester, or ester equivalent, to form the intermediate diketone (6) which is used without further purification. In step 2, diketone (6) in an anhydrous protic solvent, such as absolute ethanol or acetic acid, is treated with the hydrochloride salt or the free base of a substituted hydrazine at reflux for 10 to 24 hours to afford a mixture of pyrazoles (7) and (8) . Recrystallization from diethyl ether/hexane or chromatography affords (7), usually as a light yellow or tan solid. Scheme III NaθCH 3 , MeOH R 2 C0 2 CH 2 CH 3 , ether 10 11 12 Synthetic Scheme III shows the procedure for preparation of 4,5-dihydrobenz[g]indazole compounds embraced by Formula I. In step 1, ethyl trifluoroacetate is reacted with base, such as 25% sodium methoxide in a protic solvent, such as methanol, and a 1-tetralone derivative (9) to give the intermediate diketone (10). In step 2, the diketone (10) in an anhydrous protic solvent, such as absolute ethanol or acetic acid, is treated with the free base or hydrochloride salt of a substituted hydrazine at reflux for 24 hours to afford a mixture of pyrazoles (11) and (12). Recrystallization gives the 4,5-dihydro benz[g]indazolyl-benzenesulfonamide (11) . Scheme IV 13 Synthetic Scheme IV shows the preparation of pyrazole compounds (13), where R 3 is chlorine, from the available pyrazole compounds (7), where R 3 is hydrogen. Chlorination results from passing a stream of chlorine gas at room temperature through a solution containing (7) . Scheme V 17 Synthetic Scheme V shows the preparation of substituted ketones 18 which are not commercially available as used in Scheme I. The ketones can be prepared by standard Friedel-Craft acylation of the starting substituted benzenes 14 with acid chlorides or anhydrides 15. Alternatively, the ketones can be prepared from phenylcarbonitriles 16 by standard organometallic techniques where M represents metals such as lithium, magnesium, and the like. An alternative organometallic route is shown from the aldehydes 17 where M represents metals such as lithium, magnesium, and the like. Oxidation with a suitable oxidizing agent, such as Crθ3, follows to produce the ketones. Scheme VI 21 Synthetic Scheme VI shows an alternative regioselective method of constructing the pyrazole 21. Commercially available enones 19 can be epoxidized to give epoxyketones 20, which are treated with 4- sulfonamidophenylhydrazine hydrochloride to provide the pyrazole 21. 97/11704 65 Scheme VII 22 23 Synthetic Scheme VII shows the preparation of pyrazoles 23 (where R 4 is 3-amino-4-substituted phenyl) from starting material 22. Appropriate 5-(4-substituted aryl)pyrazoles can be nitrated next to the R-group under standard nitration conditions and the nitro group reduced to the amino group, preferably with hydrazine and Pd/C. The amino compounds can be further manipulated by alkylation of the amino group. Scheme VIII 26 Synthetic Scheme VIII shows the preparation of pyrazoles 26 from esters 24. Reduction of the ester 24 to the alcohol, preferably with lithium aluminum hydride (LAH) followed by oxidation, preferably with Mnθ2, gives the aldehyde 25. Various nucleophiles (such as hydroxamates and 1,3-dicarbonyl compounds) can be condensed with the aldehyde to give the desired oximes or olefins 26. The following examples contain detailed descriptions of the methods of preparation of compounds of Formulas I- II. These detailed descriptions fall within the scope, and serve to exemplify, the above described General Synthetic Procedures which form part of the invention. These detailed descriptions are presented for illustrative purposes only and are not intended as a restriction on the scope of the invention. All parts are by weight and temperatures are in Degrees centigrade unless otherwise indicated. HRMS is an abbreviation for High resolution mass spectrometry. In the following tables, "ND" represents "not determined". Example 1 4- [5- ( -Chlorophenyl) -3- (trifluoromethyl) IH-pyrazol-l-yl]benzenesulfonamide 97/11704 67 Step 1; Preparation of 4.4.4-trifluoro-1-f4- (chloro)phenvπ-butane-1.3-dione . Ethyl trifluoroacetate (23.52 g, 166 mmol) was placed in a 500 mL three-necked round bottom flask, and dissolved in methyl tert-butyl ether (75 mL) . To the stirred solution was added 25% sodium methoxide (40 mL, 177 mmol) via an addition funnel over a 2 minute period. Next 4'-chloroacetophenone (23.21 g, 150 mmol) was dissolved in methyl tert-butyl ether (20 mL) , and added to the reaction dropwise over 5 minutes. After stirring overnight (15.75 hours), 3N HCl (70 mL) was added. The organic layer was collected, washed with brine (75 mL) , dried over MgS04, filtered, and concentrated in vacuo to give a 35.09 g of yellow-orange solid. The solid was recrystallized from iso-octane to give 31.96 g (85%) of the dione: mp 66-67°C. Step 2; Preparation of 4-f5- (4-chlorophenyl)-3- ftrifluorQm . ethyi)-Iff-pyrasQl-l- yl1benzenesulfonam de, 4-Sulphonamidophenylhydrazine hydrochloride (982 mg, 4.4 mmol 1.1 equivalent) was added to a stirred solution of 4,4,4-trifluoro-1-[4-(chloro)phenyl]-butane- 1,3-dione from Step 1 (1.00 g, 4.0 mmol) in ethanol (50 mL) . The reaction was heated to reflux and stirred for 20 hours. (HPLC area percent showed a 96:3 ratio of 4-[5- (4- chlorophenyl)-3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide to its regioisomer (4-[3- (4- chlorophenyl)-5- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide) . After cooling to room temperature, the reaction mixture was concentrated in vacuo . The residue was taken up in ethyl acetate, washed with water and with brine, dried over MgS04, filtered, and concentrated in vacuo to give a light brown solid which was recrystallized from ethyl acetate and iso-octane to give the pyrazole (1.28 g, 80%, mp 143-145°C) . HPLC showed that the purified material was a 99.5:0.5 mixture of 4- [5- (4- chlorophenyl ) -3- (trifluoromethyl) -ltf-pyrazol-l- yl] benzenesulfonamide to its regioisomer. 1H NMR (CDCI3/CD3OD 10/1) d 5.2 (s, 2H) , 6.8 (s, IH) , 7.16 (d, j = 8.5 Hz, 2H) , 7.35 (d, j = 8.5 Hz, 2H) , 7.44 (d, j = 8.66, 2H) , 7.91 (d, j = 8.66, 2H) ; 1 C NMR (CDCI3/CD3OD 10/1) d 106.42 (d, j = 0.03 Hz), 121.0 (q, j = 276 Hz), 125.5, 126.9, 127.3, 129.2, 130.1, 135.7, 141.5, 143.0, 143.9 (q, j = 37 Hz), 144.0; 19F NMR (CDCI3/CD3OD 10/1) d -62.9. El GC-MS M+ = 401. Example 2 4- [5- (4-Methylphenyl) -3- (trifluoromethyl) - IH-pyra zol- 1-yl] benzenesulf onamide Step 1; Preparation of 1- (4-methvlphenvl) -4.4.4- tri luorobutang-i,3-dione 4' -Methylacetophenone (5.26 g, 39.2 mmol) was dissolved in 25 mL of methanol under argon and 12 mL (52.5 mmol) sodium methoxide in methanol (25%) was added. The mixture was stirred for 5 minutes and 5.5 mL (46.2 mmol) ethyl trifluoroacetate was added. After refluxing for 24 hours, the mixture was cooled to room temperature and concentrated. 100 mL 10% HCl was added and the mixture extracted with 4 X 75 mL ethyl acetate. The extracts were dried over MgS04, filtered and concentrated to afford 8.47 g (94%) of a brown oil which was carried on without further purification. 7/11704 69 Step 2 ; Preparation of 4-T5-(4-methylphenyl)-3- (trifluoromethyl)-lH-pvrazol-1- vl1benzenesulfonamide To the dione from Step 1 (4.14 g, 18.0 mmol) in 75 mL absolute ethanol was added 4.26 g (19.0 mmol) 4- sulphonamidophenylhydrazine hydrochloride. The reaction was refiuxed under argon for 24 hours. After cooling to room temperature and filtering, the reaction mixture was concentrated to afford 6.13 g of an orange solid. The solid was recrystallized from methylene chloride/hexane to give 3.11 g (8.2 mmol, 46%) of the product as a pale yellow solid: mp 157-159'C; Anal, calc'd for C17H14N3O2SF3: C, 53.54; H, 3.70; N, 11.02. Found: C, 53.17; H, 3.81; N, 10.90. Example 3 4 - [5- ( 3 , 5 -Dichloro- -methoxyphenyl ) -3 ( tri f luoromethyl ) - lH-pyrazol - 1 - yl ] benzenesulfonamide Step 1 : Preparation of , 5-dichloro-4- rc thoxyflcetoph none To a cooled solution (0'C) of 7.44 g (55.8 mmol) AICI3 in 25 mL of CH2CI2 under argon was added 2.5 mL of acetic anhydride dropwise. After stirring for 0.5 hours, 4.18 g (23.6 mmol) of 2,6-dichloroanisole was added dropwise. The reaction was stirred at O'C for 1 hour, warmed to room temperature and stirred for 12 hours. The reaction was poured into 6 mL cone, hydrochloric acid/80 mL ice water. The aqueous phase was extracted with ethyl acetate (3 X 75 mL) . The combined organic washes were dried over MgS04, filtered, and stripped to afford the crude product as a yellow oil. NMR analysis showed that acylation only occured para to the methoxy. The crude oil was used without any further purification. Steps 2 and 3; Preparation of 4- \5- ( .5-dichloro-4- methoxvphenvl) -3-(trifluoromethyl)-lH-pvrazol- 1-vllbenzenesulfonamide The title compound was prepared in the same manner as Example 2, Steps 1 and 2 and was purified on a prep plate eluting with 10:1 hexane/ethyl acetate to afford a yellow solid: Anal, calc'd for C17H12N3O3SF3CI2Η2O: C, 42.16; H, 2.91; N, 8.68. Found: C, 42.03; H, 2.54; N, 8.45. Example 4 4- [5- (3 -Ethyl -4 -methoxyphenyl) -3- (trifluoromethyl) IH -pyrazol -1-yl] benzenesulfonamide Step 1: Preparation of -ethvl-4-met-.hoxvacetθPhenone AICI3 (4.9 g, 36.8 mmol) was added to a solution of 2-ethylanisole (2.5 g, 18.4 mmol) in methylene chloride (50 mL) . Acetyl chloride (1.3 mL, 18.4 mmol) was added dropwise to the reaction mixture, which was then stirred at reflux for 0.5 hours. After cooling to room temperature, the reaction was poured over crushed ice and followed up with a methylene chloride/water extraction. The organic layer was dried over magnesium sulfate, filtered and concentrated. The crude product was chromatographed on a 4000 micron chromatotron plate with 10% ethyl acetate/90% hexane as eluant to afford 2.3 g of desired material. Step? 2 an 3; Preparation of 4- f5- (3-ethvl-4- methoxyphenyl) -3- ( rifluoromethyl) -1H- pvrazol-1-vllbenzenesulfonamide The title compound was prepared using the procedure described in Example 2, Steps 1 and 2: Anal. calcd for C19H18N3O3SF3 : C, 53.64; H, 4.26; N, 9.88. Found: C, 53.69; H, 4.36; N, 9.88. Example 5 4- [5- (3-Methyl-4-methylthiophenyl) -3 (trifluoromethyl) -lH-pyrazol-1- yl] enzenesulfonamide Step 1: Preparation of 2-methvlthioanisole Methyl iodide (0.5 mL, 8.1 mmol) and potassium carbonate (1.1 g, 8.1 mmol) were added to a solution of o- thiocresol (1.0 g, 8.1 mmol) in 10 mL of DMF. The reaction was stirred at 50'C for 4 hours and poured into hexane and water. The organic layer was separated, dried over magnesium sulfate and concentrated to afford 1.1 g of desired material. Steps 2, 3 nd 4; Preparation of 4-T5- (3-methyl-4- methvlthiophenvl)-3-(trifluoromethyl) -1H- pvrazol-l-vllbenzenesulfonamide The title compound was prepared using the procedures found in Example 4, Steps 1, 2 and 3: Anal, calcd. for C18H16N3O2S2F3: C, 50.58; H, 3.77; N, 9.83. Found: C, 50.84; H, 3.62; N, 9.62. 4- [5- (3- (3-Propenyl) -4-methoxyphenyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide Step 1: Preparation of 3-allvl-4-methoxvacetophenone Potassium hydroxide (3.2 g, 56.8 mmol) was added to a solution of 3-allyl-4-hydroxyacetophenone (10 g, 56.8) in 125 mL THF. Dimethyl sulfate (excess) was added and the reaction was stirred at 50"C for 16 hours. The reaction was cooled, concentrated and poured into EtOAc and water. The organic layer was separated and washed with dilute sodium hydroxide to get rid of unreacted starting material. The ethyl acetate layer was dried and concentrated to afford 9.2 g of 3-allyl-4-methoxy acetophenone. Steps 2 and 3: Preparation of 4-f5-(3-(3-propenyl) -4- methoxvphenvl)-3-(trifluoromethyl)-lH-ovrazol- 1-vllbenzenesulfonamide The title compound was prepared using the procedures described in Example 2, Steps 1 and 2: Anal, calc'd for C20 H 18 N 3 F 3°3 S: C ' 54.92; H, 4.15; N, 9.61. Found: C, 54.70; H, 4.12; N, 9.43. Example 7 4- [5- ( 3 -Propyl -4 -methoxyphenyl ) -3 - (trifluoromethyl) -lH-pyrazol -1 - yl ] benzenesulfonamide Step 1: Preparation of 3-n-propyl-4-methoxvacetophenone To a solution of the product in Example 6, Step 1 (3 g, 17.0 mmol) in 50 mL of ethanol was added a catalytic amount of 4% Pd/C. The reaction mixture was stirred in a Parr shaker at room temperature at 5 psi hydrogen for 0.5 hours. The reaction was filtered and concentrated to afford 4 g of pure 3-propyl-4-methoxy acetophenone. Ste S 2 n 3; Preparation of 4-f5- (3-n-propvl-4- methoxyphenyl)-3-(trifluoromethyl)-lH-ovrazol- 1-vllbenzenesulfonamide The title compound was prepared using the procedures described in Example 2, Steps 1 and 2: Anal. calcd. for C20 H 20 N 3 F 3°3 S: c - 54.66; H, 4.59; N, 9.56. Found: C, 54.84; H, 4.65; N, 9.52. Example 8 4- [ 5- ( 3 - Cyclop ropy Imethyl -4 -methoxyphenyl ) -3- ( rifluoromethyl ) - IH-pyra zol -1 - yl ] benzenes lfonamide Step 1: Preparation of 3-cvclopropvlmethvl-4- methoxvacetophenone To a solution of the product in Example 6, Step 1 (3 g, 17.0 mmol) and catalytic Pd(0Ac)2 in 20 mL Et2θ was added ethereal diazomethane until starting material was consumed. The reaction was filtered, concentrated and chromatographed on a 4000 micron chromatotron plate (20% EA/80% hexane as eluant) to afford 2.5 g of desired ketone. Ste 2 and 3; Preparation of 4-L5- (3-cvclopropvlmethvl- 4-methoxyphenyl)-3- (trifluoromethyl) -1H- pvrazol-1-vllbenzenesulfonamide The title compound was prepared using the procedures described in Example 2, Steps 1 and 2: Anal, calc'd. for C21H20N3F3SO3: C, 55.87; H, 4.47; N, 9.31. Found: C, 55.85; H, 4.27; N, 9.30. Example 9 4- [4-Methyl-3-nitrophenyl) -3- {trifluoromethyl-lH' pyrazol-1-yl]benzenesulfonamide To a solution of the product of Example 2 (500 mg, 1.31 mmol) in 5mL of sulfuric acid was added nitric acid (0.6 mL, 1.31 mmol) and the reaction was stirred at room temperature for 0.5 hours. The mixture was poured over ice, the solid precipitate was filtered and chromatographed on a 4000 micron plate (20% EtOAc/80% hexane as eluant) to afford 410 mg of desired material: Anal, calc'd for C 17 H 13 N 4 0 4 SF 3 : C, 47.89; H, 3.07; N, 13.14. Found: C, 47.86; H, 2.81; N, 13.15 Example 10 4- [5- ( 3-Amino-4-methylphenyl ) -3- ( trifluoromethyl) - IH-pyrazol -1-yl ] benzenesulfonamide A catalytic amount of 10% Pd/C was added to a solution of hydrazine hydrate (0.022 mL, 0.7 mmol) in 10 mL of ethanol. The reaction mixture was refiuxed for 15 minutes before the addition of the compound from Example 9 (100 mg, 0.23 mmol), and the resulting reaction mixture was refiuxed for another 2 hours. The reaction was cooled, filtered through Celite and concentrated to afford 100 mg of title compound: Anal, calc'd for C17H15N4O2SF3 «0.5 CO2 : C, 50.24; H, 3.61; N, 13.39. Found: C, 50.49; H, 3.44; N, 13.37. Example 11 4- [5- ( 4-Hydroxymethylphenyl ) -3- (trifluoromethyl ) IH-pyrazol-l-yl] benzenesulfonamide Step 1; Preparation of 4-f5- (4-bromomethvlphenvl) -3- (trifluoromethyll-lH-nvrazol-l- vl1benzenesulfonamide The product from Example 2 (1.13 g, 3.0 mmol) and N-bromosuccinimide (NBS, 0.64 g, 3.6 mmol) were dissolved in 40 mL of benzene and irradiated with a UV lamp for 3 hours. The reaction was cooled to room temperature and poured into 50 mL of H2O. The organic phase was separated, washed with brine and dried over MgS04. The crude pyrazole was obtained as an amber oil. The oil was purified via radical band chromatography eluting with 30% ethyl acetate/70% hexane to afford the 4-bromomethyl compound as a yellow oil which crystallized upon standing. Step 2; Preparation of 4-f5- (4-hvdroxvmethvlphenvl)-3- ( rifluoromethyl)-lH-nvrazol-1- vl1benzenesulfonamide The bromo methyl compound from Step 1 was dissolved in 30 mL of acetone/4 mL of H2O and refiuxed for 120 hours. The reaction was concentrated and the residue dissolved in 50 mL of ethyl acetate and dried over MgS04. The crude product was obtained as an amber oil. The oil was purified via radial band chromatography eluting with 30% ethyl acetate/70% hexane to afford the title compound as a yellow solid: Anal, calc'd for C17H14N3O3SF3 : C, 51.38; H, 3.55; N, 10.57. Found: C, 51.28; H, 3.59; N, 10.31. Example 12 4- [1- (4- (Aminosulfonyl)phenyl) -3- (trifluoromethyl) - lH-pyrazol-5-yl]benzoic acid To the product from Example 11 in 2 mL of acetone was added 1.33 M Jones reagent until an orange color persisted. The reaction was poured into 20 mL of ethyl acetate and 20 mL of H20 and the organic layer separated, washed with saturated sodium bisulfite and dried over MgSθ4. The crude product was filtered through silica gel/Celite to afford the title compound as a yellow solid: HRMS m/z 411.0507 (calc'd for C17H12N3O4SF3, 411.0500). The following compounds in Table I were prepared according to procedures similar to that exemplified in Examples 1-12, with the substitution of the appropriate acetophenone. TABLE I Ex . M. P . (°c) Analytical sO 13 4 -Br 137-139 Calc. C, 43.07; H, 2.48; N, 9.42; Br, 17.91 Obs. C, 43.01; H, 2.32; N, 9.39; Br, 17.62 10 14 3 -C1 154-155 Calc. C, 47.83; H, 2.76;N, 10.46; Cl, 8.82 Obs. C, 47.61; H, 2.85; N, 10.31; Cl, 8.43 15 2 -C1 159-160 Calc. C, 47.83; H, 2.76; N, 10.46 Obs. C, 47.47; H, 2.65; N, 10.31 16 4 -CF3 144-145 Calc. C, 46.90; H, 2.55; N, 9.65 15 Found: C, 46.98; H, 2.57; N, 9.61 17 4 -F 168-169 Calc. C, 49.87; H, 2.88; N, 10.90 Found: C, 49.83; H, 2.89; N, 10.86 TABLE I ( cont . ) Ex . M . P . (°C ) Analytical 164-165 Calc. C, 52.31; H, 3.29; N, 11.43 Found: C, 52.14; H, 3.07; N, 11.34 10 153-154 Calc. C, 51.38; H, 3.55; N, 10.57 Found: C, 51.00; H, 3.48; N, 10.24 101-103 Calc. C, 45.24; H, 2.46; N, 9.31 Found: C, 45.22; H, 2.37; N, 9.29 126-128 Calc. C, 53.54; H, 3.70; N, 11.02 15 Found: C, 53.52; H, 3.55; N, 11.06 127-130 M+H 404 178-180 M+H 404 196-197.5 TABLE I (cont.) Ex. M.P. (°C) Analytical oo 145-147 Calc. C, 44.05; H, 2.31; N, 9.63; Cl, 16.25 Found: C, 44.00; H, 2.20; N, 9.63; Cl, 16.46 10 153-155 Calc.C, 43.87; H, 2.35; N, 9.59 Found: C, 43.78; H, 2.13; N, 9.56 169-172 (dec) Calc. C, 46.61; H, 2.69; N, 13.59; S, 7.78 Obs.: C, 46.52; H, 2.67; N, 13.51; S, 7.84 28 2-F 165-166 Calc. C, 49.87; H, 2.88; N, 10.90 15 Found: C, 49.49; H, 2.62; N, 10.79 29 4-NH2 124-127 (dec) HRMS: 382.0671 30 4-F, 2-CH3 170-171 Calc. C, 51.13; H, 3.28; N, 10.52 Found: C, 50.83, H, 2.98; N, 10.55 TABLE I (cont.) Ex. M.P. (°C) Analytical 00 ro 135-137 Calc. C, 53.54; H, 3.70; N, 11.02 Found: C, 53.15; H, 3.58; N, 10.96 141-142 Calc. C, 51.43; H, 4.08; N, 9.99 10 Found: C, 51.49; H, 3.80; N, 10.08 143-144 Calc. C, 53.64; H, 4.26; N, 9.87 Found: C, 53.49; H, 4.39; N, 9.64 143-144 Calc. C, 49.87; H, 2.88; N, 10.90 Found: C, 49.80; H, 2.80; N, 10.84 15 155-156 Calc. C, 49.16; H, 3.15; N, 10.11 Found: C, 48.77; H, 2.93; N, 9.96 165-166 Calc. C, 49.39; H, 3.41; N, 10.16 Found: C, 49.48; H, 3.46; N, 10.26 TABLE I (cont.) Ex. M.P. (°C) Analytical 00 u> 37 4-C1, 3-CH3 ND Calc. C, 49.10; H, 3.15; N, 10.11 Found: C, 49.00; H, 3.00; N, 10.10 38 4-CH2CH3 ND Calc. C, 54.68; H, 4.08; N, 10.63 10 Found: C, 54.54; H, 3.73; N, 10.67 39 2,4-di-CH3 ND Calc. C, 54.68; H, 4.08; N, 10.63 Found: C, 54.31; H, 4.32; N, 10.39 40 2-OCH3 167-168 Calc. C, 51.38; H, 3.55; N, 10.57 Found: C, 51.29; H, 3.34; N, 10.52 15 41 4-OCH3, 3-CH3 146-147 42 4-SCH3, 3-Br 141-144 HRMS: 490,9595 43 4-CH3, 3-Cl 186-190 Calc. C, 49.10; H, 3.15; N, 10.11 Found: C, 49.21;H, 3.17; N, 10.10 TABLE I ( cont . ) Ex . M . P . (°C) Analytical s 192-193 Calc. C, 50.58; H, 3.77; N, 9.83 Found: C, 50.58; H, 3.83; N, 9.72 166-168 Calc. C, 47.29; H, 3.03; N, 9.73 10 Found: C, 47.21; H, 2.91; N, 9.55 ND Calc. C, 48.49; H, 3.39; N, 9.42 Found: C, 48.27; H, 3.42; N, 9.22 163-164 Calc. C, 49.16; H, 3.15; N, 10.12 Found: C, 49.32; H, 3.27; N, 10.18 15 ND Calc. C, 50.58; H, 3.77; N, 9.83 Found: C, 50.40; H, 3.78; N, 9.83 49 4-F, 3-Cl ND Calc. C, 45.78; H, 2.40; N, 10.01 Found: C, 45.75; H, 2.34; N, 10.15 TABLE I (cont.) Ex. M.P. (°c) Analytical co <J1 50 4-OCH3, 3,5-di-F ND Calc. C, 47.12; H, 2.79; N, 9.70 Found: C, 46.72; H, 2.75; N, 9.54 51 4-SCH3, 3-F ND Calc. C, 47.33; H, 3.04; N, 9.74 10 Found: C, 47.25; H, 3.39; N, 9.45 52 4-SCH3, 3-Cl ND Calc. C, 45.59; H, 2.93; N, 9.38 Found: C, 45.56; H, 2.76; N, 9.52 53 4-N ( CH3 ) 2 ND HRMS: 410.1016 54 4-N(CH 2 CH 3 ) 2 ND HRMS: 438.1353 15 Example 55 4- [5- ( 4-Hydroxy-3-methylphenyl) -3™ ( trif luoromethyl) -lH-pyrazol-1 - yl ] benzenesulfonamide To a solution of the product of Example 41 (240 mg, 0.58 mmol) in DMF (3 mL) was added NaSMe (205 mg, 2.9 mmol) and the mixture heated to reflux for 2 hours. The mixture was cooled, poured into 0.1N HCl and extracted with EtOAc (3x) . The combined extracts were dried over MgS04 and concentrated. Flash chromatography using 1:1 hexane/ethyl acetate provided 31 mg of the title compound: Anal, calc'd for C17H14N3O3SF3 *»0.25 H2O: C, 50.80; H, 3.64; N, 10.45. Found: C, 50.71; H, 3.47; N, 10.39. Example 56 4- [5- (4- (N-Methylamino) phenyl) -3- (trifluoromethyl) IH-pyrazol-l-yl ] benzenesulfonamide To a solution of the product from Example 53 (431 mg, 1.0 mmol) in 10 ml methanol was added 36 mg (0.17 mmol) ruthenium (III) chloride hydrate, followed by 1.5 mL 30% hydrogen peroxide (14.7 mmol) over 2 hours. The reaction was quenched with 25 mL of IM KOH in methanol and concentrated to give 1.24 g of a brown solid. The solid was purified on a prep plate eluting with 2/97/1 methanol/methylene chloride/ammonium chloride to give 52 mg (0.14 mmol, 12%) of the product as a yellow solid. Example 57 N- [4- [1- [4- (Aminosulfonyl ) phenyl ] - 3 - ( trifluoromethyl ) - IH-pyra zol- 5 -yl ] phenyl ] -N- me thy lac et mide 19 mg (0.051 mmol) of the product from Example 56 was treated with 0.03 mL acetic anhydride (0.32 mmol) and 0.03 mL triethylamine (0.22 mmol) in 3 mL methylene chloride at room temperrature for 12 hours. The reaction mixtured was concentrated and the residue dissolved in 10 mL ethyl acetate. After washing with brine (2 x 10 mL) , the solution was dried over MgS04, filtered and concentrated to afford the title compound (18.4 mg, 74%) as a yellow solid: HRMS m/e 438.0976 (calc'd for C19H17N4O3SF3, 438.0974) . oo Example 58 4- [5- ( 4-Chlorophenyl) -3- (difluoromethyl) IH-pyrazol-1-yl]benzenesulfonamide Step 1; Preparation of 4.4-difluoro-1- 14- (chloro)phenvl1 -butane-1.3-dione. Ethyl difluoroacetate (24.82 g, 200 mmol) was placed in a 500 mL three-necked round bottom flask, and dissolved in diethyl ether (200 mL) . To the stirred solution was added 25% sodium methoxide in methanol (48 mL, 210 mmol) via an addition funnel over a 2 minute period. Next, 4' -chloroacetophenone (25.94 g, 200 mmol) was dissolved in diethyl ether (50 mL) , and added to the reaction dropwise over 5 minutes. After stirring overnight (18 hours), IN HCl (250 mL) and ether (250 mL) were added. The organic layer was collected, washed with brine (250 mL) , dried over MgS04, filtered, and concentrated in vacuo to give 46.3 g of a yellow solid. The solid was recrystallized from methylene chloride and iso-octane to give 31.96 g (69%) of the dione: mp 65-66.5°C. Step 2: Preparation of 4- '5- ( -chlorophenyl) -3- (difluoromethyl) -ljV-pvrazol-1- yllbenzenesulfonamide 4-Sulphonamidophenylhydrazine hydrochloride (1.45 g, 6.5 mmol 1.3 equivalent) and 4, -difluoro-1- [4- (chloro)phenyl]butane-1,3-dione from Step 1 (1.16 g, 5 mmol) were dissolved in ethanol (10 mL) . The reaction was heated to reflux and stirred for 20 hours. After cooling to room temperature, the reaction mixture was concentrated in vacuo . The residue was taken up in ethyl acetate (100 mL) , washed with water (100 mL) and with brine (100 L) , dried over MgS04, filtered, and concentrated in vacuo to give 1.97 g of a light brown solid which was recrystallized from ethanol and water to give 4-[5- (4-chlorophenyl) -3- (difluoromethyl)-IH-pyrazol-l-yl]benzenesulfonamide (1.6 g, 83%) : mp 185-186°C. Example 59 4- [5- (3-Fluoro-4-methoxyphenyl ) -3- (difluoromethyl) - IH-pyrazol-l-yl] benzenesulfonamide Step 1: Preparation of '-fluoro-4'-methoxv- acetoohenone. Aluminum chloride (80.0 g, 0.6 mol) and chloroform (750 mL) were placed in a 2 L three-necked round bottom flask fitted with a mechanical stirrer and cooled by means of an ice bath. To the stirred solution acetyl chloride (51.0 g, 0.65 mol) was added dropwise, maintaining the temperature between 5-10°C. The mixture was stirred for 10 minutes at 5°C before the dropwise addition at 5-10°C of 2-fluoroanisole (62.6 g, 0.5 mol). The mixture was stirred at 0-10°C for 1 hour and poured into ice (1 L) . The resultant layers were separated and the aqueous layer was extracted with dichloromethane (2x250 mL) . The combined organic layers were washed with water (2x150 mL) , dried over anhydrous MgSθ 4 , filtered and concentrated in vacuo to a volume of 300 mL. Hexanes were added and a white solid formed which was isolated by filtration and air dried. This material was recrystallized from a mixture of dichloromethane and hexanes to afford (77.2 g, 92%) of material suitable for use in the next step: mp 92-94°C; iH NMR (DMSO-d 6 ) 7.8 (m, 2H) , 7.3 (t, IH) , 3.9 (s, 3H) , 2.5 (s, 3H) . Step 2 ; Preparation of 4.4-difluoro-1- (3-fluoro-4- methoxvphenvl) -butane-1. -dione. Ethyl difluoroacetate (4.06 g, 32.7 mmol) was placed in a 250 mL Erlenmeyer flask, and dissolved in methyl tert-butyl ether (50 mL) . To the stirred solution was added 25% sodium methoxide (7.07 g, 32.7 mmol) followed by 3'-fluoro-4'-methoxyacetophenone from Step 1 (5.0 g, 29.7 mmol). After stirring for 16 hours, IN HCl (50 mL) was added. The organic layer was collected, washed with water (2x50 mL) , dried over anhydrous MgS0 4 , filtered, and added to hexanes to precipitate a tan solid (7.0 g, 96%): mp 70- 72°C; iH NMR (DMSO-d 6 ) 8.0 (m, 3H) , 7.3 (t, IH) , 6.9 (s, IH) , 6.5 (t, IH) , 3.9 (s, 3H) . Step 3: Preparation of 4-T5- (3-fluoro-4- methoxyphenyl)-3-(difluoromethyl)-lH-pvrazol- 1-yl1benzenesul onamide• 4,4-Difluoro-1- (3-fluoro-4-methoxyphenyl)- butane-1,3-dione from Step 2 (7.0 g, 28.4 mmol) was dissolved in ethanol (150 mL) . To the stirred mixture was added 4-sulphonamidophenylhydrazine hydrochloride (7.4 g, 33 mmol) and stirred at reflux overnight (16 hours) . The mixture was cooled and water was added until crystals slowly appeared. The product was isolated by filtration and air dried to provide the desired product as a light tan solid (9.8 g, 87%): mp 159-161°C; i H NMR (DMSO-d 6 ) 7.85 (d, 2H) , 7.5 (m, 6H) , 7.3-6.9 (m, 5H) , 3.8 (s 3H) . Anal. Calc'd for Ci7Hi N 3 S0 3 F 3 : C, 51.38; H, 3.55; N, 10.57. Found: C, 51.46; H, 3.52; N, 10.63. Example 60 4- [3-Difluoromethyl-5- ( -methoxyphenyl) -1-H- pyrazol-1-yl]benzenesulfonamide Step 1. Preparation of 4.4. -trifluoromethyl-1- (4- methoxyphenyl)butane-1. -dione. To a stirred solution of 4-methoxyacetophenone (11.43 g, 76.11 mmol) and ethyl difluoroacetate (8.4 mL, 10.4 g, 83.72 mmol) in diethyl ether (300 mL) in a 500 mL round bottomed flask was added sodium methoxide in methanol (18.2 mL of a 25% solution, 79.91 mmol). The solution became a dark lavender color within thirty minutes, and then a gray suspension within 1.5 hours. The reaction was stirred for 60 hours. Diethyl ether (300 mL) was added and the mixture was acidified (pH 2) with IN HCl. The mixture was transferred to a separatory funnel, mixed and separated. The ethereal phase was washed with water, dried over magnesium sulfate, and filtered. Hexane was added causing precipitation of an orange solid 5.25 g of 4,4,4- trifluoromethyl-1-(4-methoxyphenyl)butane-1,3-dione. An additional 3.43 g of product was obtained by recrystallization of the concentrated mother liquor from hexane: X H NMR (CDCI 3 ) 400 mHz 15.58 (br s, 1 H) , 7.94 (d, J = 8 . 87 Hz , 2H) , 6 . 98 (d, J = 8 .87 Hz , 2H) , 6 . 49 (s , IH) , 6 .00 (t , J = 54 .55 Hz , 1 H) , 3 . 89 ( s , 3H) . Step 2. Preparation of 4- '5- (4-methoxyphenyl) -3- difluoromethyl-1-H-ρyrazoi-i- vll enzenesulfonamide, A mixture of 4, 4,4-trifluoromethyl-1- (4- methoxyphenyl)butane-l, 3-dione from Step 1 (2.006 g, 8.79 mmol) and 4-sulfonamidophenylhydrazine hydrochloride salt (2.065 g, 9.23 mmol) dissolved in ethanol (25 mL) was heated to reflux for 16 hours. The reaction was cooled to room temperature, was concentrated and recrystallized from methanol yielding 4- [5- (4-methoxyphenyl) -3-difluoromethyl- 1-H-pyrazol-l-yl]benzenesulfonamide as fluffy tan crystals (1.49 g, 45%): mp 133-135°C; *H NMR (CDCI 3 ) 300 mHz 7.90 (d, J = 8.863 Hz, 2H) , 7.45 (d, J = 8.863 Hz, 2H) , 7.14 (d, J = 8.863 Hz, 2H) , 6.88 (d, J = 8.863 Hz, 2H) , 6.77 (t, J = 56.47 Hz, IH) , 6.68 (s, 1 H) , 4.96(br s, 2 H) , 3.83(s, 3 H) ; 19 NMR (CDCI 3 ) 300 mHz -112.70 (d, J = 57.9 Hz) . High resolution mass spectrum Calc'd for C1 7 H 15 F2N3O 3 S: 379.0802. Found: 379.0839. Elemental analysis calc'd for C1 7 H1 5 F2N 3 O 3 S: C, 53.82; H, 3.99; N, 11.08. Found: C, 53.75; H, 3.99; N, 11.04. The following compounds in Table II were obtained according to procedures similar to that exemplified in Examples 58-60, with the substitution of the appropriate acetophenone. TABLE II Ex. M.P. (°C) Anal VO 10 15 TABLE II (cont.) Ex, M.P. (°C) Anal v Calc. C, 54.54; H, 3.23; N, 14.97 Obs. : C, 54.58; H, 3.21; N, 15.06 Calc. C, 51.32; H, 3.55; N, 10.56 10 Obs: C, 51.46; H, 3.53; N, 10.53 Calc. C49.34; H,3.41; N, 10.15; Cl,8.57; S,7.75 Obs. : C,49.41; H,3.37; N, 10.17; Cl.8.62; S,7.67 Calc. C, 51.32; H, 3.55; N, 10.56 Obs. : C, 51.42; H, 3.57; N, 10.53 15 Calc. C, 52.81; H, 4.19; N, 10.26 Obs. : C, 52.86; H, 4.19; N, 10.20 75 3,5-di-Cl, 4-OCH3 170-173 Calc. C, 45.55; H, 2.92; N, 9.37 Obs. : C, 45.83; H, 3.05; N, 9.31 TABLE II (cont.) Ex, M.P. (°C) Anal . o 76 3,5-di-F, 4-OCH 3 149-150 Calc. C, 49.16; H, 3.15; N, 10.12 Obs.: C, 49.24; H, 3.16; N, 10.13 77 2-OCH 3 129-132 Calc. C, 53.82; H, 3.99; N, 11.08 10 Obs.: C, 53.82; H, 3.97; N, 11.15 78 3-Br, 4-OCH 3 164 HRMS : 456.9883 79 4-SO2CH3 209-210 80 -C6H5 167-170 M+ 425 81 H 171-172 HRMS: 349.0737 15 Example 82 4- [5- (1, 3-Benzodioxol-5-yl) -3- (difluoromethyl) -IH- pyrazol-1-yl]benzenesulfonamide Step 1, Preparation of 1- (1.3-benzodioxol-5-vl) -4. - difluorobutane-1.3-dione. Ethyl difluoroacetate (1.72 g, 11 mmol) was dissolved in ether (25 mL) . To the stirred solution was added 25% sodium methoxide (2.38 g, 11 mmol) followed by 3 ', 4 '- (methylenedioxy)acetophenone (1.64 g, 10 mmol) . After stirring 16 hours, IN HCl (25 mL) was added. The organic layer was collected and washed with water (2x25 mL) , dried over magnesium sulfate, filtered, and concentrated. The resulting crude dione was used in the next step without further purification or characterization. Step 2. Preparation of 5- (1.3-benzodioxol-5-vl) -4- f3- (di uoromethyl)- H-pyrazQl-1- yj1benzen . esvIfonamide, 1- (l,3-Benzodioxol-5-yl) -4, 4-difluorobutane-l,3- dione from Step 1 (2.4 g, 10 mmol) was dissolved in ethanol (100 mL) . To the stirred mixture was added 4- sulfonamidophenylhydrazine hydrochloride (2.46 g, 11 mmol) and heated to reflux for 16 hours. The mixture was cooled and water was added until crystals slowly appeared. Filtration yielded a light tan solid (3.3 g, 84 %) : mp 214-218°C; iH NMR (D 6 -DMSO) : 7.86 (d, J=8.7Hz, 2H) , 7.51 (d, J=8.7Hz, 2H) , 7.49 (brs, 2H) , 7.3-6.7 (m, 5H) , 6.06(s, 2H) . Anal. Calc'd for C17H13N3SO4F2: C 51.91; H, 3.33; N, 10.68. Found: C, 51.90; H, 3.25; N, 10.65. Example 83 4 - [4- (Aminosulfonyl ) phenyl ] -5- ( 4 -chlorophenyl ) - lf -pyrazole-3-carboxylic acid Step 1: Preparation of methvl-4- ' 4- (chloro )phenvll - 2 , 4 -dioxobutanoate . Dimethyl oxalate (23.6 g, 200 mmol) was placed in a 500 mL three-necked round bottom flask, and dissolved in diethyl ether (200 mL) . To the stirred solution was added 25% sodium methoxide in methanol (48 mL, 210 mmol) via an addition funnel over a 2 minute period. Next, 4'- chloroacetophenone (25.94 g, 200 mmol) was dissolved in diethyl ether (50 mL) , and added to the reaction dropwise over 3 minutes. After stirring overnight (18 hours), IN HCl (400 mL) and ethyl acetate (750 mL) were added. The organic layer was collected, washed with brine (350 mL) , dried over MgS04, filtered, and concentrated in vacuo to give 45.7 g of a yellow solid. The solid was recrystallized from ethyl acetate and iso-octane to give 23 g (48%) of the dione: mp 108.5-110.5°C. Step 2; Preparation of 4-'4-(aminosulfonyl)phenvll- 5-(4-chlorophenyl)-lff-pyrazole- - carboxylic acid 4-Sulphonamidophenylhydrazine hydrochloride (1.45 g, 6.5 mmol, 1.3 equivalent) and methyl-4-[4- (chloro)phenyl] -2,4-dioxobutanoate (1.2 g, 5 mmol) were dissolved in ethanol (50 mL) . The reaction was heated to reflux and stirred for 20 hours. After cooling to room temperature, the reaction mixture was concentrated in vacuo . The residue was taken up in ethyl acetate (200 mL) and washed with water (100 mL) and brine (100 mL) , dried over MgS04 filtered and concentrated in vacuo to give 1.7 g of a light brown solid which was recrystallized from methanol and water to yield 1.6 g (85%) of a white solid. This material was dissolved in methanol (150 mL) and 3N NaOH (75 mL) and stirred at reflux for 3 hours. The methanol was removed in vacuo and the aqueous solution acidified with concentrated HCl. The product was extracted into ethyl acetate (200 mL) , which was washed with brine (100 mL) , dried over MgSθ4 filtered and concentrated to give 4-[4- (aminosulfonyl)phenyl] -5-(4-chlorophenyl) -1H- pyrazole-3-carboxylic acid, 1.4 g (74%): mp 135°C (dec). Example 84 Methyl 1-(4-aminosulfonylphenyl) -5- (3, 5-difluoro-4- methoxyphenyl) -l-H-pyrazole-3-carboxylate Step 1, Preparation of .5-difluoro-4-methoxy- acetophenone. To a stirred suspension of AICI 3 (24.05 g, 180.40 mmol) in chloroform (300 mL, dried by passage through alumina) at 4°C (ice bath) under nitrogen was added acetyl chloride (11.0 mL, 152.65 mmol) over 20 minutes. This chilled suspension was stirred at 0°C for 30 minutes and 2,6-difluoro anisole was added dropwise over 30 minutes. The resulting suspension was warmed to room temperature and stirred overnight. The reaction was quenched by slowly pouring it into a rapidly stirred ice/water mixture. The water layer was extracted with methylene chloride (2x50 mL) and the organic phases were combined and concentrated in vacuo yielding a clear mobile oil. In a 50 mL round bottomed flask was added the above clear oil, DMF (25 mL) , K 2 CO 3 (15 g) . Methyl iodide (6 mL) was added and the suspension stirred at 45°C under nitrogen overnight. Water (1 mL) was added and the mixture was heated for an additional 14 hours. The crude reaction mixture was cooled to room temperature, diluted with water (250 mL) and extracted with diethyl ether (3x100 mL) . The ether phase was washed with sodium bicarbonate saturated solution, potassium bisulfate (0.1 N solution), dried over MgSθ 4 , filtered and concentrated in vacuo yielding a clear mobile liquid. This liquid was distilled (30°C, 1 mm) yielding 12.5 g of a clear liquid which was a mixture of 3,5- difluoro-4-methoxyacetophenone and 3,5-difluoro-4- acetoxyacetophenone in an 85:15 ratio. The yield based upon this ratio was 41%. This ketone was used as is. Sten 2. Preparation of methvl l-(4- aminosulfonvlphenvl)-5- (3.5-difluoro-4- methoxyohenvl)-l-H-Pvrazole- -carboxylate To a stirred solution of 3,5-difluoro-4- methoxyacetophenone from Step 1 (6.46 g, 34.70 mmol) and dimethyl oxalate (6.15 g, 52.05 mmol) in methanol (80 mL) , was added sodium methoxide solution (13.4 mL of 25% solution, 58.99 mmol) in one portion and the reaction stirred overnight. The crude reaction was diluted with methylene chloride, washed with potassium bisulfate (0.1N solution) , brine, dried over MgSθ 4 , filtered, and concentrated in vacuo yielding methyl 4-(3,5-difluoro-4- methoxyphenyl) -2,4-dioxo-butanoate as an off white crystalline solid which was used as is. A mixture of 4- (3,5-difluoro-4-methoxyphenyl) -2,4-dioxo-butanoate and 4- sulfonamidophenylhydrazine hydrochloride salt (7.76 g, 34.70 mmol) dissolved in methanol was warmed to reflux for 9 hours. Upon allowing the clear reaction to cool to room temperature, a crystalline precipitate formed which was collected by vacuum filtration yielding 5.45 g, (37% based upon the 3,5-difluoro-4-methoxyacetophenone) of methyl 1- (4-aminosulfonylphenyl) -5-(3,5-difluoro-4-methoxyphenyl) -1- H-pyrazole-3-carboxylate as an off-white solid: mp 185- 190°C; λ E NMR (CDCl 3 /300 mHz) 7.95 (d, J = 8.86, 2H) , 7.49 (d, J = 8.86, 2H) , 7.02 (s, IH) , 6.77 (m, 2H) , 4.99 (s, 2H) , 4.04 (s, 3 H) , 3.98 (s, 3H) ; 19 F NMR (CDCl 3 /300 mHz) -126.66. Anal. Calc'd for C17H13F2N3O3S : C, 51.06; H, 3.57; N, 9.92. Found: C, 51.06; H, 3.54, N, 9.99. Example 85 Methyl [1- (4-aminosuIfonylphenyl) -5- ( - chlorophenyl) -lH-pyrazole-3-yl] carboxylate Step 1. Preparation of methvl 4-T4-(chloro)phenvll- 2.4-dioxobutanoate Dimethyl oxalate (15.27 g, 0.129 mol) and 4'- chloroacetophenone (20.0 g, 0.129 mol) were charged to a 500 mL round-bottom flask, with provisions made for magnetic stirring, and diluted with methanol (300 mL) . Sodium methoxide (25% in methanol, 70 mL) was added in one portion. The reaction was stirred at room temperature for 16 hours. The reaction became an insoluble mass during this time. The solid was mechanically broken up, then concentrated hydrochloric acid (70 mL) was added, and the white suspension was stirred vigorously at room temperature for sixty minutes. The suspension was cooled to 0°C and held for 30 minutes. The soild was filtered, and the filter cake was washed with cold water (100 mL) . Upon drying, methyl 4-[4-(chloro) henyl] -2,4-dioxobutanoate was obtained (16.94 g, 54.4%) as the enol: X E NMR (CDCI 3 /3OOMHZ) 7.94 (d, J=8.66 Hz, 2H) , 7.48 (d, J=8.66 Hz, 2H) , 7.04 (s, IH) , 3.95 (s, 3H) , 3.48 (s, IH) . Step 2 - Preparation of methvl f1- (4- aminosulfonvlphenvl) -5- (4-chlorophenvl)-1H- pvrazole-3-vl1carboxylate. A 100 mL round-bottomed flask equipped with magnetic stirrer and nitrogen inlet was charged with methyl 4-[4- (chloro)phenyl] -2,4-dioxobutanoate from Step 1 (5.0 g, 20.78 mmol), 4-sulfonamidylphenylhydrazine hydrochloride (5.11 g, 22.86 mmol) and methanol (50 mL) . The reaction vessel was heated to reflux and held for 16 hours. A precipitate formed overnight. The suspension was cooled to 0°C, held for 0.5 hour, filtered and washed with cold water to provide, after air-drying, 7.91 g (91%) of crude product. Recrystallized 3.50 g from boiling ethanol to yield 3.14 g (97%) of pure methyl [l-(4- aminosulfonylphenyl) -5- (4-chlorophenyl) -lH-pyrazole-3- yl]carboxylate: mp 227°C; ^-H NMR (CDCl 3 /300MHz) 7.91 (d, J=8.86 Hz, 2H) , 7.44 (d, J=8.86 Hz, 2H) , 7.33 (d, J=8.66 Hz, 2H) , 7.14 (d, J=8.66 Hz, 2H) , 7.03 (s, IH) , 3.96 (s, 3H) . Mass Spectrum, MH+ = 392. Anal. Calc'd for C 1 7H 14 N3O 4 CIS: C, 52.11; H, 3.60; N, 10.72; Cl, 9.05; S, 8.18. Found: C, 52.07; H, 3.57; N, 10.76; Cl, 9.11; S, 8.27. Example 86 Ethyl [1- ( -aminosulfonylphenyl) -5-( - chlorophenyl) -lH-pyrazole-3-yl] carboxylate Methyl [1- (4-aminosulfonylphenyl) -5- (4- chlorophenyl)-lH-pyrazole-3-yl]carboxylate (Example 85) (0.10 g) was dissolved in absolute ethanol (10 mL) and a catalytic amount of 21% NaOEt/EtOH was added. The reaction was stirred without temperature control for 72 hours, then water (10 mL) was added. The product crystallized, the suspension was cooled to 0°C and held for 30 minutes. The product was filtered, washed with water (5 mL) and dried to yield 0.071 g (70%) of a white solid: Mass Spectrum: MH+ = 406. Anal. Calc'd for C 18 H 16 N 3 O 4 CIS: C, 53.27; H, 3.97; N, 10.35; Cl, 8.74; S, 7.90. Found: C, 53.04; H, 4.00; N, 10.27; Cl, 8.69; S, 7.97. The following compounds in Table III were prepared according to procedures similar to that exemplified in Examples 83-86, with the substitution of the appropriate reagents. TABLE III Ex. M.P. ( β C) Analytical MH+ = 403 Calc. C54.40; H,3.76; N, 11.19; S,8.54 Obs. C,54.49; H,3.70; N, 11.25; S, 8.50 10 MH+ = 373 MH+ = 438 HRMS : 387.0930 HRMS : 371.0965 Calc. C, 59.21; H, 4.97; N, 10.90 15 Obs. C, 58.73; H, 4.96; N, 10.78 94 4-C1 Calc. C, 54.35; H, 4.32; N, 10.01; Cl, 8.44; S, 7.64 Obs. C, 54.11; H, 4.28; N, 10.14; Cl, 8.54; S, 7.64 20 95 3,5-di-Cl, 4-OCH3 -CH3 225-229 Example 96 4- [4- (Aminosulfonyl)phenyl] -5- ( -chlorophenyl) - IH-pyrazole-3-carboxamide 4-[4- (Aminosulfonyl)phenyl] -5- (4-chlorophenyl) - lff-pyrazole-3-carboxylic acid (Example 83) (1.08 g, 2.86 mmol), HOBt (0.66 g, 4.3 mmol) and EDC (0.66 g, 3.4 mmol) were dissolved in dimethylformamide (DMF) (20 mL) and stirred at ambient temperature for 5 minutes. To this solution was added NH4OH (30%, 2.9 mL) and the reaction stirred for an additional 18 hours. This solution was then poured into ethyl acetate (200 mL) and IN HCl (200 mL) , shaken and separated. The organic layer was washed with saturated NaHC03 (150 mL) and brine (150 mL) , dried over MgS04, filtered and concentrated to yield 0.9 g of a white solid which was recrystallized from ethyl acetate and iso- octane to yield 4-[4-(aminosulfonyl)phenyl]-5-(4- chlorophenyl) -li-pyrazole-3-carboxamide (0.85 g, 79%): mp 108-110°C. Example 97 [1- (AminosuIfonylphenyl ) -5- ( 4-fluorophenyl-1H- pyrazol-3-yl] carboxamide A 250 mL three-neck round-bottom flask, equipped with a thermometer, gas sparging tube, reflux condenser and provisions for magnetic stirring, was charged with methyl[1- (4-aminosulfonylphenyl) -5- (4-fluorophenyl) -1H- pyrazol-3-yl] carboxylate (Example 88) (3.0 g, 7.99 mmol), methanol (100 mL) , and a catalytic amount of sodium cyanide. Anhydrous ammonia gas was sparged through the reaction vessel for 16 hours without temperature control. The suspension turned a deep red during this time. The reaction was sparged with anhydrous nitrogen at room temperature for 20 minutes, cooled to 0°C and held for 30 minutes. The solid was filtered and washed with cold water (50 mL) to yield, upon drying, 1.87 g (65%) of [l-(4- aminosulfonylphenyl) -5- (4-fluorophenyl) -lH-pyrazol-3- yl]carboxamide as a white solid: mp 214-216°C; X H NMR (CDCI 3 /CD 3 OD/3OOMHZ) 7.64 (d, J=8.66 Hz, 2H) , 7.14 (d, J=8.66 Hz, 2H) , 6.95 (m, 2H) , 6.82 - 6.67 (m,6H), 6.39(s, IH) ; 19 F NMR (CDCI3/ CD 3 OD/282.2MHz) -112.00(m) . Mass spectrum, MH+ = 361. Anal. Calc'd for C 16 H 13 N 4 O 3 FS: C, 53.33; H, 3.64; N, 15.55; S, 8.90. Found: C, 53.41; H, 3.69; N, 15.52; S, 8.96. 106 Example 98 N- ( 3-Chlorophenyl) - [1- (4-aminosuIfonylphenyl) -5- (4 fluorophenyl) -lH-pyrazol-3-yl] carboxamide Step 1, Preparation of methvl 4-f4-fluorophenvll -?. .4- dioxobutanoate. Dimethyl oxalate (18.80 g, 0.159 mol) and 4'- fluoroacetophenone (20.0 g, 0.145 mol) were charged to a 1000 mL round-bottom flask and diluted with methanol (400 mL) . The reaction flask was placed in a sonication bath (Bransonic 1200) , and sodium methoxide (25% in methanol, 70 mL) was added over 25 minutes. The reaction was sonicated at 45°C for 16 hours. The reaction became an insoluble mass during this time. The solid was mechanically broken up, then poured into a hydrochloric acid solution (IN, 500 mL) . A magnetic stirrer was added, and the white suspension was stirred vigorously at room temperature for 60 minutes. The suspension was cooled to 0°C and held for 30 minutes. The solid was filtered, and the filter cake was then washed with cold water (100 mL) . Upon drying, methyl 4-[4-fluorophenyl]-2, 4-diketobutanoate was obtained (22.91 g, 70.6%) as the enol: X H NMR (CDCl 3 /300MHz) 8.03 (ddd, J = 8.86 Hz, J=8.66 Hz, J=5.03Hz, 2H) , 7.19 (dd, J=8.86 Hz, J=8.66 Hz, 2H) , 7.04 (s, IH) , 3.95(s, 3H) . 19 F NMR (CDC1 3 /282.2 MHz) - 103.9 (m) . Step , Preparation of methvl 4-fl-(4- aminosulfonvlphenvl) -5- (4-fluorophenyl) -1H- pvrazol- -vl1carboxylate. A 500 mL one-neck round-bottom flask equipped for magnetic stirring was charged with methyl 4-[4- fluorophenyl]-2,4-diketobutanoate from Step 1 (1.00 mg, 44.61 mmol), 4-sulfonamidylphenylhyrazine hydrochloride (10.98 g, 49.07 mmol) and methanol (200 mL) . The suspension was heated and held at reflux for three hours, then cooled to room temperature. The suspension was cooled to 0°C, held for 30 minutes, filtered, washed with water (100 mL) , and dried to yield 14.4 g (86%) of methyl 4-[l- (4-aminosulfonylphenyl) -5-(4-fluorophenyl)-lH-pyrazol-3- yl]carboxylate as a white solid: λ E NMR (CDCl 3 /300MHz) 7.85 (d, J=8.66 Hz, 2H) , 7.36 (d, J=8.66 Hz, 2H) , 7.18 (ddd, J = 8.66 Hz, J=8.46 Hz, J=4.85 Hz, 2H) , 7.00 (dd, J=8.66 Hz, J=8.46 Hz, 2H) , 6.28 (s, IH) , 3.90(s, 3H) . 19 F NMR (CDCl 3 /282.2MHz) : -111.4(m). Mass spectrum, MH+ = 376. Anal. Calc'd for C 17 H 14 N 3 O 4 FS: C, 54.40; H, 3.76; N, 11.19; S, 8.54. Found: C, 54.49; H, 3.70; N, 11.25; S, 8.50. Step . Preparation of fl-(4-aminosnlfonvlphenvl) -5- (4-fluorophenvl)-lH-pvrazol-3-vncarboxylic acid. A 500 mL one-neck round-bottom flask, equipped with provisions for magnetic stirring, was charged with methyl 4-[1- (4-aminosulfonylphenyl) -5- (4-fluorophenyl)-1H- pyrazol-3-yl]carboxylate from Step 2 (10.0 g, 26.64 mmol) and tetrahydrofuran (200 mL) . Aqueous sodium hydroxide (2.5N, 27 mL) and water (25 mL) were added, and the suspension was heated to reflux and held for 16 hours. The solids all dissolved during this time. The reaction was cooled to room temperature, and hydrochloric acid solution (IN, 110 mL) was added. The aqueous suspension was extracted with methylene chloride (2x200 mL) . The combined organic soultion was dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo to an oil. Trituration with 300 mL of methylene chloride yielded, upon filtration and drying, 9.0 g, (94%) of [l-(4- 5 aminosulfonylphenyl)-5-(4-fluorophenyl)-lH-pyrazol-3- yl]carboxylic acid as a white solid: mp 138-142°C (dec); 1 H NMR (CD 3 OD/300MHz) 7.93 (d, J=8.66 Hz, 2H) , 7.51 (d, J=8.66 Hz, 2H) , 7.31 (ddd, J = 8.86 Hz, J=8.66 Hz, J=4.83 Hz, 2H) , 7.11 (dd, J=8.86 Hz, J=8.66 Hz, 2H) , 7.06 (s, IH) . 19 F NMR D (CD 3 OD/282.2MHz) : -114.01(m). Step 4. Preparation of N- (3-chlorophenyl) -ri-(4- aminosulfonvlphenvl) -5-(4-fluorophenyl) -1H- pvrazol-3-vl1carboxamide 5 A 100 mL one-neck round-bottom flask, equipped with provisions for magnetic stirring, was charged with [1- (4-aminosulfonylphenyl) -5- (4-fluorophenyl) -lH-pyrazol-3- yl]carboxylic acid from Step 3 (0.500 g, 1.38 mmol), 1- 0 hydroxybenzotriazole hydrate (0.206 g, 1.522 mmol), l-(3- dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.318 g, 1.66 mmol) and N,N-dimethylformamide (30 mL) . The solution was stirred at room temperature for forty minutes, then 3-chloroaniline (0.154 mL, 1.453 mmol) was 5 added. The reaction was held at room temperature for sixteen hours, then poured into an aqueous solution of citric acid (5%, 100 mL) . The aqueous solution was extracted with ethyl acetate (2x60 mL) , and the combined organic solutions were washed with aqueous citric acid (60 0 mL) , saturated sodium bicarbonate solution (2x60 mL) and 50% saturated sodium chloride solution (2x60 mL) . The organic solution was dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo to an oil. Trituration with 20 mL of dichloromethane yielded, upon 5 filtration and drying, 0.439 g (67%) of N-(3-chlorophenyl) - [1-(4-aminosulfonylphenyl)-5-(4-fluorophenyl) -lH-pyrazol-3- yl]carboxamide as a white solid: mp 207-212°C; 1 H NMR (CDCI 3 /CD 3 OD/3OOMHZ) 8.90 (s, IH) , 7.86 (d, J=8.66 Hz, 2H) , 7.79 (t, J=2.01 Hz, IH), 7.46 (dd, J = 7.05 Hz, J=2.01 Hz, IH) , 7.33 (d, J=8.86 Hz, 2H) , 7.21-7.11 (m, 3H) , 7.02 - 6.94 (m, 4H) . 19 F NMR (CDCI 3 /CD 3 OD/282.2MHz) : -111.38 (m) . Mass spectrum, MH+ = 470. Anal. Calc'd for C 22 H 16 N 4 O 3 CIFS: C, 56.11; H, 3.42; N, 11.90; Cl, 6.81; S, 7.53. Found: C, 55.95; H, 3.50; N, 11.85; Cl, 6.82; S, 7.50. The following compounds in Table IV were prepared according to procedures similar to that exemplified in Examples 96-98, with the substitution of the appropriate starting material. rH TABLE IV (cont.) Ex. A M.P. Analytical _^C_ 110 4-OCH 3 H 115-140 Calc. C54.83; H,4.33; N, 15.04 Obs. C, 54.76; H.4.34; N, 14.98 H 139-140 HRMS-H20: 356.0939 10 -CH 3 209 MH+ = 387 glycine benzyl ester 136 H+ = 525 glycine 124-130 MH+ = 435 H ND M+Li = 457/459 H 185 (dec) HRMS: 440.0113 15 Example 117 4- [3-Cyano-5- (4-fluorophenyl-IH-pyrazol-1- yl]benzenesulfonamide A dry 100 ml three-neck flask, equipped with a reflux condenser, thermometer, pressure-equalizing addition funnel and provisions for magnetic stirring was charged with anhydrous DMF (20 mL) and cooled to 0°C. Oxalyl chloride (0.530 mL, 6.105 mmol) was added over twenty seconds, causing a 5°C exotherm. The white precipitate formed dissolved as the reaction cooled to 0°C. The reaction was held at 0°C for ten minutes, then a solution of [1- (4-aminosulfonylphenyl) -5- (4-fluorophenyl) -1H- pyrazol-3-yl]carboxamide (Example 97) in anhydrous DMF was added to the vigorously stirring solution over approximately two minutes. After fifteen minutes, pyridine (1.0 mL, 12.21 mmol) was added to quench the reaction. The mixture was poured into dilute hydrochloric acid (IN, 100 mL) and extracted with ethyl acetate (2x75 mL) . The combined organic solution was washed with IN HCl (2x100 mL) and with 50% saturated NaCl (3x100 mL) . The organic solution was dried over magnesium sulfate, filtered and concentrated in vacuo to a crude oil. The oil was applied to a column of silica gel and eluted with ethyl acetate and hexane (40% ethyl acetate) to obtain, upon concentration of the appropriate fractions, 0.66 g (69%) of 4- [3-cyano-5- (4- fluorophenyl-lH-pyrazol-l-yl]benzenesulfonamide as a white solid: mp 184-185°C; X H NMR (CDCl 3 /300MHz) 7.94 (d, J=8.86 Hz, 2H) , 7.44 (d, J=8.86 Hz, 2H) , 7.23-7.07 (m, 4H) , 6.87 (S, IH) , 4.88 (brs, 2H) ; 19 F NMR (CDCI 3 /282.2MHz) -109.90(m). Mass spectrum, MH+ = 343. Anal. Calc'd for C 16 H 11 N 4 O 2 FS: C, 56.14; H, 3.24; N, 16.37; S, 9.36. Found: C, 56.19; H, 3.16; N, 16.39; S, 9.41. The following compounds in Table V were prepared according to procedures similar to that exemplified in Example 117, with the substitution of the appropriate starting material. TABLE V Ex. M.P. (°C) Anal HRMS: 401.9833 10 HRMS : 354.0774 HRMS: 338.0849 MH+ = 389 HRMS : 422.0051 15 MH+ = 433 MH+ = 370 Example 128 4- [5- (4-Chlorophenyl) -3- (heptafluoropropyl) - lff-pyrazol-1-yl]benzenesulfonamide Step 1: Preparation of . .5.5.6.6.6-heotafluoro-1-f4- (chloroIphenvllhexane-l. -dione. Ethyl heptafluorobutyrate (5.23 g, 21.6 mmol) was placed in a 100 mL round bottom flask, and dissolved in ether (20 mL) . To the stirred solution was added 25% sodium methoxide (4.85 g, 22.4 mmol) followed by 4-chloroacetophenone (3.04 g, 19.7 mmol). The reaction was stirred at room temperature overnight (15.9 hours) and treated with 3N HCl (17 mL) . The organic layer was collected, washed with brine, dried over MgSθ4 concentrated in vacuo , and recrystallized from iso-octane to give the diketone as a white solid (4.27 g, 62%) : mp 27-30°C; lH NMR (CDCI3) 300 MHz 15.20 (br s, IH) , 7.89 (d, J=8.7 Hz, 2H) , 7.51 (d, J=8.7 Hz, 2H) , 6.58 (S, IH) ; 19F NMR (CDCI3) 300 MHz: -80.94 (t), -121.01 (t) , -127.17 (s) ; M+H 351. Steo 2: Preparation of 4- \ 5- (4-chloroohenvl) -3- (hePtafluoropropvl)-lH-pvrazol-l- vllbenzenesulfonamide The 4-sulfonamidophenylhydrazine hydrochloride (290 mg, 1.30 mmol) was added to a stirred solution of the diketone from Step 1 (400 mg, 1.14 mmol) in ethanol (5 mL) . The reaction was heated to reflux and stirred overnight (23.8 hours). The ethanol was removed in vacuo, and the residue was dissolved in ethyl acetate, washed with water and brine, dried over MgSθ4, and concentrated in vacuo to give a white solid which was passed through a column of silica gel with ethyl acetate/hexane (40%) and recrystallized from ethyl acetate/isooctane to give the pyrazole as a white solid (0.24 g, 42%): mp 168-71°C; lH NMR (CDCI3) 300 MHz 7.90 (d, J=8.7 Hz, 2H) , 7.45 (d, J=8.7 Hz, 2H) , 7.34 (d, J=8.5 Hz, 2H) , 7.19 (d, J=8.5 Hz, 2H) , 6.79 (s, 1 H) , 5.20 (br s, 2H) ; 19F ΝMR (CDCI3) 300 MHz: -80.48 (t), -111.54 (t), -127.07 (s) . Example 129 4- [5- (4-Chlorophenyl) -3- (chloro-difluoromethyl) - IH-pyrazol-1-yl]benzenesulfonamide Step 1: Preparation of 4-chloro-4.4-difluoro-1-T4- (ςhlorρ)phenyπ -buζane-1, -dione, Methyl 2-chloro-2,2-difluoroacetate (4.20 g, 29 mmol) was placed in a 100 mL round bottom flask, and dissolved in ether (10 mL) . To the stirred solution was added 25% sodium methoxide (6.37 g, 29 mmol) followed by 4'-chloroacetophenone (4.10 g, 26.5 mmol). The reaction was stirred at room temperature overnight (20.4 hours), then poured into a separatory funnel and washed w th 3Ν HCl (15 mL) , brine (20 mL) , dried over MgS04, and concentrated in vacuo and recrystallized from iso-octane to give the diketone as a yellow solid (3.78 g, 53%): mp 53-55°C; 1H NMR (CDCI3) 300 MHz 14.80 (br s, IH) , 7.87 (d, J=8.7 Hz, 2H) , 7.50 (d, J=8.7 Hz, 2H) , 6.49 (S, IH) ; 19F NMR (CDCI3) 300 MHz: -66.03 (s); M+ 267. Step 2: Preparation of 4-T5-(4-chlorophenyl)-3- (chloro-difluoromethyl)-lH-pvrazol-1- vllbenzenesulfonamide 4-Sulfonamidophenylhydrazine hydrochloride (1.39 g, 6.2 mmol) was added to a stirred solution of the diketone from Step 1 (1.43 g, 5.7 mmol) in ethanol (10 mL) . The reaction was heated to reflux and stirred overnight (15.75 hours). The ethanol was removed in vacuo, and the residue was dissolved in ethyl acetate, washed with water and brine, dried over MgSθ4, and concentrated in vacuo to give a white solid which was recrystallized from ethyl acetate/isooctane to give the pyrazole as a white solid (0.32 g, 41%): mp 130-33°C; 1H NMR (CDCI3) 300 MHz 7.90 (d, J=8.9 Hz, 2H) , 7.47 (d, J=8.7 Hz, 2H) , 7.35 (d, J=8.5 Hz, 2H) , 7.19 (d, J=8.7 Hz, 2H) , 6.76 (s, 1 H) , 5.13 (br s, 2H) ; 19 F NMR (CDCI3) 300 MHz: -48.44 (s); M+ 417/419. Example 130 4- [3- (Dichloromethyl) -5- (3-fluoro-4- methoxyphenyl) -IH-pyr zol-1-yl]benzenesulfonamide Ste I . Preparation of 3'-flύoro-4'-methoxy¬ acetophenone. Aluminum chloride (80.0 g, 0.6 mol) and chloroform (750 mL) were placed in a 2 L three-necked round bottom flask fitted with a mechanical stirrer and cooled by means of an ice bath. To the stirred solution was added acetyl chloride (51.0 g, 0.65 mol) dropwise, maintaining the temperature between 5-10°C. The mixture was allowed to stir for 10 minutes, at 5°C before the dropwise addition at 5-10°C of 2-fluoroanisole (63.06 g, 0.5 mol).The mixture was stirred at 0-10°C for 1 hour and poured into ice (1 L) . The resultant layers were separated and the aqueous layer was extracted with methylene chloride (2x250 mL) . The combined organic layers were washed with water (2x150 mL) , dried over magnesium sulfate, and concentrated to 300 mL. Hexanes were added and a white solid (77.2 g, 92%) was crystallized from the mixture: mp 92-94°C; 1 H NMR (dζ- DMSO) 7.8 (m, 2H) , 7.3 (t, J=8.7Hz, IH) , 3.9 (S, 3H) , 2.5 (s, 3H) . Step 2. Preparation of 4.4-dichloro-l-(3-fluoro-4- methoxyphenyl) -butane-1,3-dione. Methyl dichloroacetate (1.57 g, 11 mmol) was dissolved ether (25 mL) . To the stirred solution was added 25% sodium methoxide (2.38 g, 11 mmol) followed by 3' -fluoro-4'-methoxyacetophenone from Step 1 (1.68 g, 10 mmol) . After stirring 16 hours IN HCl (25 mL) was added. The organic layer was collected and washed with water (2x25 mL) , dried over magnesium sulfate, filtered, and concentrated. The resulting crude dione was used in the next step without further purification or characterization. Step 3. Preparation of 4- \ 3 - (dichloromethyl) -5- (3- fluoro- -methoxyphenyl ) -lH-Pvrazol-1- vllbenzenesulfonamide. 4,4-Dichloro-l- (3-fluoro-4-methoxyphenyl) - butane-1,3-dione from Step 2 (2.8 g, 10 mmol) was dissolved in ethanol (100 mL) . To the stirred mixture was added 4-sulfonamidophenylhydrazine hydrochloride (2.46 g, 11 mmol) and heated to reflux for 16 hours. The mixture was cooled and water was added until crystals slowly appeared. Filtration yielded a light tan solid (2.7 g, 63 %) : mp 190-193°C; X H NMR (DMS0-d β ) 7.84 (d, J=8.4Hz, 2H) , 7.53 (s, IH) , 7.48 (d, J=8.4Hz, 2H) , 7.47 (brs, 2H) , 7.3-7.0 (m, 3H) , 6.95 (s, IH) , 3.85 (s, 3H) . Anal. Calc'd for C 1 7H 14 N 3 SO3FCI 2 : C, 47.45; H, 3.28; N, 9.76. Found: C, 47.68; H, 3.42; N, 10.04. Example 131 4- [3-Fluoromethyl-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide Step 1: Preparation methyl 4-phenvl-2. -dioxobutanoate To a solution of dimethyl oxalate (11.81 g, 100 mmol) in ether (200 mL) is added 24 mL of 25% sodium methoxide in methanol, followed by a solution of acetophenone (12.02 g, 100 mmol) in ether (20 mL) and the mixture stirred overnight at room temperature. The mixture was partitioned between IN HCl and EtOAc and the organic layer was washed with brine, dried over MgS04 and concentrated to give 18.4 g of crude butanoate. Step 2; Preparation of methvl 1-r (4- (aminosulfonyl) phenvll -5-phenvl-lH-pyrazole 3-carboxylate The ester was prepared from the butanoate in Step 1 using the procedure described in Example 2, Step 2. Step 3 : Preoara ion 4-f3-hvdroxvme hvl-5-ohenvl-1H- pvrazol-1-vl1benzenesulfonamide To a solution of ester in Step 2 (4.0 g, 10.4 mmol) in 50 mL THF was added LiAlH4 (0.592 g, 15.6 mmol) in portions and the mixture refiuxed overnight. The reaction was cooled and quenched with IN NaHSθ4 and extracted with ether (3X) . The combined extracts were dried over MgSθ4 and concentrated to give 3.5 g crude alcohol. Flash chromatography using 1:1 hexane/EtOAc provided the title compound. Step 4: Preparation 4-f3-fluoromethyl-5-phenvl-lH- pvrazol-1-yl1benzenesu fonamide To a mixture of the alcohol from Step 3 (212 mg, 0.64 mmol) in dichloromethane (4 mL) was added diethylaminosulfur trifluoride (0.13 mL, 1.0 mmol). The reaction mixture was stirred at room temperature for 3 hours and partitioned between water and dichloromethane. The aqueous solution was extracted with dichloromethane. The organic solution was washed with brine and concentrated. The residue was chromatographed on silica (1:1 hexane:ethyl acetate) to give the desired product (72 mg, 34%): mp 162-163'C; Anal, calc'd for C16H14N3O2SF: C, 58.00; H, 4.26; N, 12.68. Found: C, 57.95; H, 4.03; N, 12.58. The following compounds in Table VI were prepared according to procedures similar to that exemplified in Examples 128-131, with the substitution of the appropriate substituted acetyl and acetate starting materials. TABLE VI Ex. M.P. (°C) Anal ro Calc. C, 50.27; H, 3.43; N, 10.99 Found C, 50.34; H, 3.43; N, 10.96 10 Calc. C, 47.29; H, Found C, 47.28; H, Calc. C, 42.87; H, Found C, 42.99; H, Calc. C, 49.53; H, 15 Found C, 50.03; H, Example 137 5 4 - [ 5 - ( 2 -Pyraz inyl ) - 3 - ( dif luoromethyl ) - l.ff-pyrazol - 1 yl ] enzenesul f onamide Ste 1 : Preparation of 4 .4-dif luoro-1- (2-pyrazinyl) - butane-1. 3 -dione . ID Ethyl difluoroacetate (2.23 g, 18 mmol) was placed in a 100 mL round bottom flask and dissolved in ether (10 mL) . To the stirred solution was added 25% sodium methoxide (4.68 g, 22 mmol) followed by acetylpyrazine 15 (2.00 g,16 mmol) . After two hours stirring at room temperature, a precipitate formed and THF (10 mL) was added to the reaction. The reaction was stirred an additional 25.9 hours, then treated with 3N HCl (10 mL) . The organic layer was collected, washed with brine (20 mL) , dried over 20 MgS04, and concentrated in vacuo and recrystallized from methylene chloride/iso-octane to give the diketone as a brown solid (2.23 g, 68%); mp 103-110°C; 1H NMR (CDCI3) 300 MHz 14.00 (br s, IH) , 9.31 (d, J=1.4 Hz, IH) , 8.76 (d, J=2.4 Hz, IH) , 8.68 (dd, J=1.4 Hz 2.4 Hz, IH) , 7.20 (s, 25 IH) , 6.03 (t, J=54.0 Hz, IH) ; 19F NMR (CDCI3) 300 MHz: -127.16 (d) ; M+ 200. Step 2: Preparation of 4-f5- (2-Pvrazinvl) -3- (difluoromethvl)-lH-pvrazol-l- 30 vl1benzenesulfonamide 4-Sulfonamidophenylhydrazine hydrochloride (0.37 g, 1.65 mmol) was added to a stirred suspension of the diketone from Step 1 (0.30 g, 1.50 mmol) in ethanol (10 mL) . The reaction was heated to reflux and stirred for 5.3 hours. The ethanol was removed in vacuo, and the residue was dissolved in ethyl acetate, washed with water (20 mL) , brine (20 mL) , dried over MgS04, and concentrated in vacuo to give a brown solid (0.36 g) which was recrystallized from ethyl acetate/ethanol/isooctane to give the pyrazole as a brown solid (0.20 g, 38%): mp 191-94°C; 1H NMR (acetone d6) 300 MHz 8.94(d, J=1.4 Hz, IH) , 8.62 (d, J=2.4 Hz, IH) , 8.52 (dd, J=1.4 Hz 2.4 Hz, IH) , 7.95 (d, J=8.7 Hz, 2H) , 7.61 (d, J=8.7 Hz, 2H) , 7.30 (s, IH) , 7.02 (t, J=54.6 Hz, IH) , 6.73 (br s, 2 H) ; 19F NMR (acetone de) 300 MHz: -113.67 (d) ; M+ 351. Example 138 4- [5- (4 -methyl-1, 3 -benzodioxol -5 -yl ) -3- ( trif luoromethyl ) -lH-pyrazol -1- yl ] benzenesulfonamide Step 1: Preparation of 4-methvl-l .3-benzodioxole 11.6 g Adogen 464 and 7 mL of dibromome thane were refiuxed in 50 mL of H20 for 0.5 hours under argon. 3-Methylcatechol (8.89 g, 71.6 mmol) was added over 2 hours and the mixture refiuxed for an additional 1 hour. Distillation of the product from the reaction mixture afforded the title compound as a yellow oil: HRMS m/e 136.0524 (calc'd for C8H8O2, 136.0524). 5 Step 2: Preparation of 5-acetvl-4-methyl-l. - benzodioxole (A) and 6-acetyl-4-methyl-l,3- benzodioxQle (g) 13.8 g of polyphosphoric acid and 5 mL of acetic ID anhydride were heated to 45"C under a drying tube of CaS04 until liquified. The product from Step 1 was added and the reaction was stirred at 45 * C for 4.5 hours. The reaction was cooled to room temperature and quenched with 150 mL of ice water. The aqueous phase was washed with ethyl acetate 15 (4x 50 mL) . The combined organic extracts were dried over MgS04 and filtered to give the crude product as a red oil. The oil was chromatographed on silica gel eluting with 10% ethyl acetate/90% hexane to afford two products: A: Anal, calcd for C10H10O3: C, 67.07; H, 5.66. Found: C, 67.41; 20 H, 5.75, and B: MS, M+ 178. Steps 3 and 4: 4- T5-(4-methyl-l.3-benzodioxol-5-vl) -3- ( rifluoromethyl) -lH-pyrazol-1- vllbenzenesulfonamide 25 The title compound was prepared from product A. using the procedures described in Example 2, Steps 1 and 2: White solid: Anal, calcd for C18H14N3O4SF3 : C, 50.82; H, 3.22; N, 9.88. Found: C, 50.71; H, 3.34; N, 9.55. 30 The following compounds in Table VII were prepared according to procedures similar to that exemplified in Examples 137-138, with the substitution of the appropriate starting material. 35 TABLE VII Ex. B M.P. (°C) Anal . 139 5-bromo-2-thienyl CF 2 H 168-169 M+Li 440/442 (J 140 2-thienyl CF 2 H 190-191 M+Li 367 141 5-chloro-2-thienyl CF 2 H 168-170 M+ 389/391 10 142 1-cyclohexenyl CF2H 160-161 M+ 353. 143 1,4-benzodioxan CF2H 115-119 Calc. C,53.06; H,3.71; N, 10.32 Obs. C52.40; H,3.98; N,9.96 144 4-methylcyclohex-3-ene-l-yl CF2H 164-168 HRMS: 367.1194 145 2-methylcyclopenten-l-yl CF2H 165-166 HRMS: 353.1033 15 146 2,5-dimethyl-3-thienyl CF2H 125-127 Calc. C,50.12; H,3.94; N, 10.96 Obs. C50.21; H,3.92; N, 11.00 147 2,5-dimethyl-3-furyl CF2H 139-142 Calc. C52.31; H,4.12; N, 11.44 Obs. C52.07; H,4.16; N,11.37 148 5-methyl-2-furyl CF2H 177-179 Calc C50.99; H,3.71; N, 11.89 20 Obs. C,51.08; H,3.68; N, 11.95 TABLE VII (cont.) Ex, B M.P. (°C) Anal 149 4-bromo-4-methylcyclohex-l-yl CF2H 175-178(dec) HRMS: 448.0520 r 150 4-methylcyclohex-l-yl CF2H 190-192 HRMS: 369.1341 151 4-chloro-4-methylcyclohex-l-yl CF2H 197-199 HRMS: 403.0958 10 152 3, 4-dibromo-4-methylcyclohex-l-yl CF2H 172-173 153 2-me hoxycyclohex-l-yl CF2H 177-179 HRMS: 386.1357 154 2-benzofuryl CF2H 215-217 Calc C, 55.52; H,3.37; N, 10.79 Obs. C55.52; H,3.32; N, 10.85 155 2, 5-dichloro-3-thien-yl CF 2 H 154-156 Calc. C39.63; H, 2.14; N, 9.90 15 Obs. C,39.63; H,2.13; N, 9.89 156 2-benzofuryl CF3 227-228 Calc. C, 53.07; H, 2.97; N, 10.31 Obs. C, 53.02; H, 2.96; N, 10.39 157 5-chloro-2-thienyl CF3 161-165 HRMS: 406.9784 20 TABLE VII (cont.) Ex. B M.P. (°C) Anal . 158 5-bromo-2-thienyl CF 3 ND Calc: C37.18; H,2.01; N,9.29; Br, 17.67 Found: C, 37.25; H, 1.93; N, 9.45; 10 Br, 17.40 159 5-indanyl Calc: C, 56.01; H, 3.96; N, 10.31 Found: C, 56.02; H, 4.06; N, 10.22 160 5-methylthien-2-yl Calc. C, 46.51; H, 3.12; N, 10.85 Found: C, 46.17; H, 3.10; N, 10.75 15 161 2, 3-dihydrobenzofuryl Calc. C, 52.81; H, 3.45; N, 10.26 Found: C, 52.67; H, 3.78; N, 10.13 162 1-cyclohexenyl HRMS: 371.0918 163 6-tetrahydronaphthyl Calc. C, 57.00; H, 4.31; N, 9.97 Found: C, 56.72; H, 4.27; N, 9.90 20 TABLE VII (cont.) Ex, B M.P. (°C) Anal 164 3-benzothienyl C, 51.06; H, 2.86; N, 9.92 C, 50.96; H, 2.73; N, 9.78 165 3, 4-dihydrobenzopyrany1 : 423.0855 10 166 styryl C, 54.96; H, 3.59; N, 10.68 Obs. C, 54.77; H, 3.59; N, 10.47 167 4-methyl-l, 3-benzodioxol-6-yl CF3 ND Calc. C, 50.82; H, 3.22; N, 9.88 Obs . C, 50.64; H, 3.35; N, 9.72 168 3-pyridyl CF3 202-204 Calc C, 48.91; H, 3.01; N, 15.21 15 Obs . C, 48.97; H, 3.16; N, 14.96 169 3, 4-dihydrobenzothiopyranyl CF3 ND Calc C51.95; H, 3.67; N, 9.56 Obs . C, 51.98; H, 3.78; N, 9.48 7/11704 129 Example 170 4- [5- (1-Cyclohexyl) -3- (difluoromethyl) -IH-pyrazol-1-yl] enzenesulfonamide 4- [5- (1-Cyclohexenyl) -3- (difluoromethyl) -IH-pyrazol-l-yl]benzenesulfonamide (Example 142) (0.31 g, 0.88 mmol) was dissolved in ethanol (15 mL) , 10% palladium on charcoal was added, and the suspension was stirred at room temperature under hydrogen (36 psi) for 18.25 hours. The reaction was filtered through celite, and the ethanol removed in vacuo to give a white solid, which was recrystallized from methylene chloride/isooctane (0.31 g, 99%): mp 199-203°C; 1H NMR (acetone-d 6 ) 300 MHz 8.05 (d, J=8.7 Hz, 2H) , 7.60 (d, J=8.5 Hz, 2H) , 6.69 (t, J=55.0 Hz 1 H) , 6.47 (s, IH) , 5.02 (br s, 2H) , 2.67 (m, IH) , 1.71- 1.88 (m, 5H) , 1.24-1.43 (m, 5H) ; 19F NMR (acetone-d 6 ) 300 MHz: -112.86 (d) . Example 171 4- [5- (4-Chlorophenyl) -3-hydroxymethyl-IH-pyrazol-1- yl]benzenesulfonamide 4-[4- (Aminosulfonyl)phenyl-5- (4-chlorophenyl)- lH-pyrazole-3-carboxylic acid (Example 83) (3.8 g, 10 mmol) and tetrahydrofuran (100 mL) were stirred at room temperature during the dropwise addition of 1.0M borane- tetrahydrofuran complex (30 mL, 30 mmol) . The mixture was heated to reflux for 16 hours. The solution was cooled and methanol was added dropwise until gas evolution ceased. Ethyl acetate (100 mL) was added and the mixture was washed successively with IN hydrochloric acid, brine, sat. aq. sodium bicarbonate solution, and water, dried over magnesium sulfate, filtered and concentrated. The resultant product was recrystallized from ethanol: ater to yield 2.6 g (71%) of a white solid: mp 192-194°C; ^-H NMR (d 6 -DMSO/300 MHz) 7.81 (d, J=8.7Hz, 2H) , 7.46 (d, J=8.4Hz, 2H) , 7.42 (brs, 2H) , 7.40 (d, J=8.7Hz, 2H) , 7.26 (d, J=8.4Hz, 2H) , 6.63 (s, IH) , 5.35 (t, J=8.0Hz, IH) , 4.50 (d, J=8.0Hz, 2H) . Anal. Calc'd for C 16 H 14 N 6 SO 2 CI: C, 52.82; H, 3.88; N, 11.55. Found: C, 52.91; H, 3.88; N, 11.50. Example 172 4- [5-Phenyl-3- (3-hydroxypropyl) - IH-pyrazol-l-yl] enzenesulfonamide A 60% dispersion of sodium hydride in mineral oil (4.0 g, 100 mmol) was twice washed with hexane (100 mL each) and dried under a stream of nitrogen. Ether (300 mL) was added followed by dropwise addition of ethanol (0.25 mL) and γ-butyrolactone (4.0 mL, 52 mmol). The mixture was cooled to 10'C and acetophenone (5.8 mL, 50 mmol) in ether (40 mL) was added dropwise over 1 hour. The mixture was warmed to 25'C and stirred overnight. The mixture was cooled to O'C and quenched with ethanol (5 mL) followed by 10% aqueous ammonium sulfate (100 mL) . The organic solution was separated, dried over Na2Sθ4 and concentrated. The residue was chromatographed on silica gel with 1:1 hexane/ethyl acetate to give the desired diketone (3.4 g) as an oil. Pyridine (0.34 mL, 4.2 mmol) and the diketone (700 mg, 3.4 mmol) in methanol (3 mL) were added to a slurry of 4-sulfonamidophenylhydrazine-HCl (750 mg, 3.4 mmol) in methanol (8 mL) . The mixture was stirred at 25'C overnight and concentrated in vacuo . The residue was dissolved in methylene chloride and the solution washed with IN HCl. The organic solution was separated, dried and concentrated. The residue was chromatographed on silica gel using ethyl acetate to give the desired pyrazole (435 mg) as a solid: Anal, calc'd for C18H19N3O3S: C, 60.49; H, 5.36; N, 11.75. Found: C, 60.22; H, 5.63; N, 11.54. Example 173 4- [5- (4 -Fluorophenyl) -3- ( 3 -hydroxypropyl ) - IH-pyrazol-l-yl ] benzenesulfonamide Following the procedure of Example 172, but substituting 4-f luoroacetophenone for acetophenone afforded 4- [5- (4- fluorophenyl) -3- ( 3 -hydroxypropyl ) -Iff- pyrazol -1 - yl] benzenesulfonamide. Anal, calc'd for Ci8HιgN3θ3SF-0.25 H20: C, 56.90; H, 4.91; N, 11.05. Found: C, 56.80; H, 4.67; N, 11.02. Example 174 4 - [4 - (Aminosulfonyl ) phenyl ] -5- ( 4 -fluorophenyl ) lff-pyrazole] -3-propanoic acid Jones reagent (0.64 mL of a 2.67 M solution) was added dropwise to a solution of 4-[5-(4-fluorophenyl) -3-(3- hydroxypropyl) -lff-pyrazol-l-yl]benzenesulfonamide from Example 173 (295 mg, 0.78 mmol) in acetone (8 mL) . The mixture was stirred at 25'C for 2 hours. The solution was filtered and the filtrate concentrated in vacuo . The residue was dissolved in ethyl acetate and washed with water (3x) . The organic solution was dried over MgS04 and concentrated. The residual oil was crystallized from ether/hexane to give the desired acid (149 mg) : mp 180- 182'C; Anal, calc'd for C18H16N3O4SF: C, 55.52; H, 4.14; N, 10.79. Found: C, 55.47; H, 4.22; N, 10.50. Example 175 4- (3-Isobutyl-5-phenyl-IH-pyrazol-1- yl)benzenesulfonamide Step 1: Preparation of 2.3-epoxy-5-methyl-l-phenyl-3- heχanone To a solution of 5-methyl-l-phenyl-l-hexen-3-one (2.0 g, 10.6 mmol) in 15 mL EtOH and 5 mL acetone was added a mixture of 30% hydrogen peroxide (2 mL) and 4 N NaOH (1.5 mL) dropwise and the mixture stirred at 25'C for 1-3 hours. Water (50 mL) was added and the precipitate filtered and dried at 40'C in vacuo to provide 1.9 g of the epoxide as a white solid: Anal, calc'd for Ci3Hi6θ2»0.1 H2O: C, 75.77; H, 7.92. Found: C, 75.47; H, 7.56. Step 2: Preparation of 4-(3-isobutvl-5-phenvl-lH- pyrazol-1-vl )benzenesulfonamide The epoxide prepared above in Step 1 (1.26 g, 6.11 mmol) and 4-sulfonamidophenylhydrazine hydrochloride (1.38 g, 6.17 mmol) were stirred in 20 mL EtOH with AcOH (0.5 mL) and the mixture refiuxed for 3 hours, cooled and quenched with 50 mL H20. The aqueous layer was extracted with ethyl acetate (3x50 mL) , the combined extracts were dried over MgS04 and concentrated. Flash chromatography using 70:30 hexane/ethyl acetate provided the title compound (0.41 g, 19%) as a white solid: Calc'd for C19H21N3O2S: C, 64.20; H, 5.96; N, 11.82. Found: C, 64.31; H, 6.29; N, 11.73. Example 176 Ethyl 3- [1- [4- (aminosulfonyl) henyl] -5-phenyl-IH- pyrazol-3-yl] -2-cyano-2-pro enoate Step 1; Preparation of 4-T3-formvl-5-phenvl-lH- pvrazol-1-vllbenzenesulfonamide To a solution of the alcohol prepared in Example 131, Step 3 (1.1 g, 3.3 mmol) in ethyl acetate (20 mL) was added Mnθ2 (5 g, 60 mmol) and the mixture stirred at room temperature overnight. The mixture was filtered through Celite and the solution was concentrated to provide the crude aldehyde. Step 2; Preparation of ethvl 3-T -T4- (aminosulfonyl)ph nvll -5-phenvl-lH-pvrazol-3- yll -2-cvano-2-propenoate To a solution of the aldehyde from Step 1 (1.2 g, 3.6 mmol) in benzene (18 mL) was added ethyl cyanoacetate (0.38 mL, 3.6 mmol), ammonium acetate (50 mg, 0.7 mmol) and glacial acetic acid (0.17 L, 2.8 mmol). The solution was heated at reflux for 18 hours, cooled, and partitioned between water and ethyl acetate. The organic solution was washed with a saturated aqueous sodium bicarbonate solution, water and brine. The organic solution was dried and concentrated. The residue was chromatographed on silica (40% hexane in ethyl acetate) to give the desired product (1.0 g, 66%): Anal, calc'd for C21HI8N4O4S: C, 59.82; H, 4.30; N, 13.22. Found: C, 59.70; H, 4.29; N, 13.26. Example 177 4- [5- ( -Chlorophenyl) -3- [ [ (phenyl e thoxy) imino] ethyl ] -lH-pyr zol-1- yl]benzenesulf onamide To a suspension of 220 mg (0.58 mmol) 4- [5- (4- chlorophenyl ) -3 -formyl-lH-pyrazol- 1-yl] benzenesulfonamide (prepared as described in Example 176, Step 1) in dichloromethane (3 mL) was added pyridine (0.12 mL, 1.3 mmol) and O-benzylhyroxylamine hydrochloride (110 mg, 0.68 mmol) and the reaction stirred at room temperature for 18 hours. The mixture was partitioned between pH 7 buffer and dichloromethane and the organic layer was washed with water, dried and concentrated. Flash chromatography on silica gel (2:1 hexane/EtOAc) provided the title compound (151 mg, 56%): mp 158-159'C; Anal, calc'd for C23Hl9N4O3SCl«0.25 H20: C, 58.59; H, 4.17; N, 11.88. Found: C, 58.43; H, 4.03; N, 11.85. The following compounds in Table VIII were prepared according to procedures similar to that exemplified in Examples 171-177, with the substitution of the appropriate starting material. Ex. M.P. (°C) Anal . 178 H -CH 2 0H 183-184 HRMS: 329.0845 179 4-OCH 3 -CH 2 0H 140-142 Calc. C, 56.81; H, 4.77; N, 11.69 OJ Found: C, 56.92; H, 4.76; N, 11.64 10 180 3,5-di-Cl, 4-OCH 3 -CH 2 0H 191-193 HRMS 427.0199 181 3-Cl, 4-OCH 3 -CH 2 0H ND Calc. C, 51.84; H, 4.09; N, 10.67 Cl, 9.00; S, 8.14 Found: C, 51.77; H, 4.02; N, 10.73; Cl, 9.11; S, 8.03 15 -C(CH 3 ) 2 OH 178-179 -(CH 2 ) 2 C0 2 H 156-159 -CH 2 CONH 2 198-200 -CH 3 ND Calc. C, 60.46; H, 5.07; N, 13.21 Found: C, 60.48; H, 4.95; N, 13.19 20 186 4-Cl -CH 2 CN 212-214 Calc. C, 54.77; H, 3.51 N, 15.03 Found : C , 54 . 94 ; H, 3 . 61 ; N, 14 . 88 Example 187 4- [4, 5-Dihydro-3- (trifluoromethyl) -IH- benz [g] indazol-l-yl]benzenesulfonamide Step 1; Pre aration Of 2-t ifluQroaςetyl-l-tetra Qne, A 250 mL one necked round bottomed flask equipped with a reflux condenser, nitrogen inlet and provisions for magnetic stirring was charged with ethyl trifluoroacetate (28.4 g, 0.2 mol) and 75 mL of ether. To this solution was added 48 mL of 25% sodium methoxide in methanol (0.21 mol). A solution of 1-tetralone (29.2 g, 0.2 mol) in 50 mL of ether was added over about 5 minutes. The reaction mixture was stirred at room temperature for 14 hours and was diluted win 100 mL of 3N HCl. The phases were separated and the organic layer was washed with 3N HCl, and with brine, dried over anhydrous MgS04, filtered and concentrated in vacuo . The residue was taken up in 70 mL of boiling ethanol/water and cooled to room temperature, whereupon crystals of 2-trifluoroacetyl-1-tetralone formed which were isolated by filtration and air dried tc give pure compound (32 g, 81%): mp 48-49°C; iH NMR CDCI 3 δ 2.8 (m, 2H) , 2.9 (m, 2H) , 7.2 (d, j = 3.0 Hz, IH) , 7.36 (m, IH) , 7.50 (m, IH) , 7.98 ( , IH) ; 19F NMR CDCI 3 δ -72.0. El GC-MS M+ = 242. Step 2; Preparation of 4- T4.5-dihvdro-3- (trifluoromethyl) -IH-benz fσi indazol-1- vllbenzenesulfonamide. A 100 mL one necked round bottomed flask equipped with reflux condenser, nitrogen inlet and provisions for magnetic stirring was charged with 2- trifluoroacetyl-1-tetralone from Step 1 (1.21 g, 5.0 mmol), 4-sulfonamidophenylhydrazine hydrochloride (1.12 g, 5.0 mmol) and 25 mL of absolute ethanol. The solution was warmed to reflux for 15 hours and concentrated in vacuo . The residue was dissolved in ethyl acetate, washed with water, and with brine, dried over anhydrous MgSθ 4 , filtered and concentrated in vacuo. The residue was recrystallized from a mixture of ethyl acetate and isooctane to give 1.40 g, 71% of pure product: mp 257-258°C; iH NMR (CDCI 3 /CD 3 OD, 4:1) δ 2.7 (m, 2H) , 2.9 (m, 2H) , 6.6 (m, IH) , 6.9 (m, IH) , 7.1 (m, IH) , 7.16 (m, IH) , 7.53 (m, 2H) , 7.92 (m, 2H) ; "F NMR (CDCI 3 ) δ -62.5. FAB-MS M+H = 394. Example 188 4- [4, 5-Dihydro-7-methyl-3- (trifluoromethyl) -IH- benz [g] indazol-1-yl]benzenesulfonamide Step l τ Preparation of 6-methvl-2- ( rifluoroacetyl) tetralone. Ethyl trifluoroacetate (5.33 g, 37.5 mmol) was dissolved in ether (50 mL) and treated with a sodium methoxide solution (25% in methanol, 9.92 g, 45.9 mmol) followed by 6-methyltetralone (5.94 g, 37.1 mmol). The reaction was stirred at room temperature for 6.1 hours then treated with 3N HCl (20 mL) . The organic layer was collected, washed with brine, dried over MgSθ 4 , and concentrated in vacuo to give a brown oil (8.09 g) that was used in the next step without further purification. Step 2. Preparation of 4-f4.5-dihvdro-7-methyl-3- (trifluoromethyl) -IH-benzfσlindazol-1- yl1benzenesulfonamide, 4-Sulfonamidophenylhydrazine hydrochloride (1.80 g, 8.0 mmol) was added to a stirred solution of the diketone from Step 1 (1.86 g, 7.3 mmol) in ethanol (10 mL) . The reaction was heated to reflux and stirred for 14.8 hours. The reaction mixture was cooled and filtered. The filtrate was concentrated in vacuo, dissolved in ethyl acetate, washed with water and with brine, dried over MgSθ 4 and reconcentrated in vacuo to give the pyrazole as a brown solid (1.90 g, 64%) : mp 215-218°C. 2 H NMR (acetone-dε) 300 MHz 8.10 (d, 2H) , 7.80 (d, 2H) , 7.24(s, IH) , 6.92 (d, IH) , 6.79 (br s, 2H) , 6.88 (d,lH), 3.02 (m, 2H) , 2.85 (m, 2H) , 2.30 (s, 3H) . 19 F NMR (acetone-ds) 282 MHz -62.46 (s) . High resolution mass spectrum Calc'd. for C 19 H 1 7F 3 N 3 O 2 Ξ: 408.0994. Found: 408.0989. The following compounds in Table IX were prepared according to procedures similar to that exemplified in Examples 187-188, with the substitution of the appropriate ester. U7. t-Ot.U/t.6 OΛV CSSl/96SflX3d Example 196 4- [4,5-Dihydro-3-(trifluoromethyl) -IH t ieno [3,2 g] indazol-1-yl]benzenesulfonamide Step l t Preparation of 4-keto-4.5.6.7- tetrahvdrothianaohthene. 4-(2-Thienyl)butyric acid (28.42 g, 167 mmol) was placed in a round bottom flask with acetic anhydride (30 mL) and phosphoric acid (0.6 mL) , and heated to reflux for 3.2 hours. The reaction mixture was poured into 100 mL of water, extracted with ethyl acetate, washed with brine, dried over MgSθ 4 , and concentrated in vacuo to give a brown oil (22.60 g) which was vacuum distilled (1mm Hg, 107- 115°C) to give a white solid (13.08 g, 51%): mp 34-40°C) ; i H NMR (CDC1 3 ) 300 MHz 7.29 (d, J=5.2 Hz, IH) , 6.99 (d, J=5.2 Hz, IH) , 2.95 (t, J=6.0 Hz, 2H) , 2.47 (m, 2H) , 2.13(m, 2H) . M+H = 153. Step 2. Preparation of 4-keto- .5.6.7-tetrahvdro-5- (trjfluQroaςeζyl)thjanapfttfrene t Ethyl trifluoroacetate (11.81 g, 83.1 mmol) was dissolved in ether (50 mL) and treated with a sodium methoxide solution (25% in methanol, 18.35 g, 84.9 mmol) followed by 4-keto-4,5,6,7-tetrahydrothianaphthene from Step 1 (12.57 g, 82.6 mmol) dissolved in ether (25 mL) . The reaction was stirred for 69.4 hours at room temperature, then treated with 3N HCl (40 mL) . The organic layer was collected, washed with brine, dried over MgSθ4, and concentrated in vacuo to give a brown solid which was recrystallized from ether/hexane to give the diketone (10.77 g, 52%) as brown needles; mp 54-64°C; X H NMR (CDCI3) 300 MHz 15.80 (s, IH) , 7.41 (d, J=5.2 Hz, IH) , 7.17 (d, J=5.2 Hz, IH) , 3.04 (m, 2H) , 2.91 (m, 2H) ; 19 F NMR (CDCI 3 ) 282 MHz -70.37 (s) . M+H=249. Step 3. Preparation of 4-f4.5-dihvdro-3- (trifluoromethyl)-lH thienor3.2-σl indazol-1- vllbenzenesulfonamide. 4-Sulfonamidophenylhydrazine hydrochloride (2.36 g, 10.6 mmol) was added to a stirred solution of the diketone from Step 2 (2.24 g, 9.0 mmol) in ethanol (20 mL) . The reaction was heated to reflux and stirred 14.7 hours. The reaction mixture was filtered and washed with ethanol and with water to give the desired pyrazole as a white solid (2.69 g, 75%) : mp 288-290°C; H NMR (acetone-d 6 ) 300 MHz 8.12 (d, J=8.7 Hz, 2H) , 7.83 (d, J=8.7 Hz, 2H) , 7.27 (d, J=5.2 Hz, IH) , 6.81 (br s, 2H) , 6.59 (s, J=5.4 Hz,lH), 3.18 (m, 2H) , 3.01 (m, 2H) ; 19 F NMR (acetone-dg) 282 MHz -62.46 (s) . High resolution mass spectrum Calc'd. for C 16 H 12 F 3 N 3 O 2 S 2 : 399.0323. Found: 399.0280. Example 197 4 - [5 - ( 4 -Chlorophenyl ) - -chloro - IH-pyrazol - 1 -yl ] benzenesulfonamide Step 1 , Preparation of 3 - U- (chloro ) phenv!1 -prooane- 1 , 3 -dione , ID Ethyl formate (8.15 g, 0.11 mol) and 4'- chloroacetophenone (15.4 g, 0.1 mol) were stirred in ether (150 mL) at room temperature. Sodium methoxide (25% ) (23.77 g, 0.11 mol) was added dropwise. The mixture was 15 stirred at room temperature for 16 hours and was then treated with 150 mL of IN hydrochloric acid. The phases were separated and the ethereal solution washed with brine, dried over magnesium sulfate, filtered and concentrated in vacuo to afford 18.3 g of a yellow oil. The resulting 20 crude mixture was used directly in the next step without purification. Step 2. Preparation of 4-f5- (4-chlorophenyl)-1H- pvrazol-1-vllbenzenesulfonamide. 25 3-[4-(Chloro)phenyl]-propane-1,3-dione from Step 1 (18.3 g, 0.1 mol) and 4-sulfonamidophenylhydrazine hydrochloride (22.4 g, 0.1 mol) were dissolved in 150 mL of absolute ethanol and heated to reflux for 16 hours. The 30 solution was cooled to room temperature, diluted with 100 mL of water and let stand, whereupon crystals of pyrazole formed that were isolated by filtration to provide 8.4 g (25%) of a white solid: mp 185-187°C; ^ NMR (CDCI3/3OO MHz) 7.89 (d, J=8.7Hz, 2H) , 7.76 (d, J=1.8Hz, IH) , 7.43 (d,J=8.7Hz, 2H) , 7.34 (d, J=8.7Hz, 2H) , 7.17 (d, J=8.7Hz, 2H) , 6.53 (d, J=1.8Hz, IH) , 4.93 (brs, 2H) . Anal. Calc'd for C 15 H 12 N 3 SO 2 CI: C, 53.97; H, 3.62; N, 12.59. Found: C, 54.08; H, 3.57; N, 12.64. Step 3. Preparation of 4-T5-(4-chlorophenyl)-4-chloro- lH-pvrazol-l-vllbenzenesulfonamide. 4-[5- (4-Chlorophenyl) -lH-pyrazol-1- yl]benzenesulfonamide from Step 2 (3.0 g, 9 mmol) was dissolved in 50 mL of acetic acid, and 9 mL of IM chlorine in acetic acid was added dropwise. The mixture was stirred for 16 hours when sat. aq. sodium bicarbonate solution was slowly added until the mixture was neutral to pH paper. The mixture was extracted with ethyl acetate (3 X 50 mL) , combined and washed with sat. aq. sodium bicarbonate and with brine, dried over magnesium sulfate, filtered, and concentrated. The resultant product was recrystallized from isopropanol to yield 2.6 g (78%) of a white solid: mp 168-171°C (dec); ^ MR (DMSO-D 6 /300 MHz) 8.08 (s, IH) , 7.83 (d, J=8.7Hz, 2H) , 7.55 (d, J=8.7Hz, 2H) , 7.46 (brs, 2H) , 7.44 (d, J=8.7Hz, 2H) , 7.35 (d, J=8.7Hz, 2H) . Anal. Calc'd for C 1 5H 11 N 3 SO 2 CI 2 : C 48.93; H, 3.01; N, 11.41. Found: C, 49.01; H, 2.97; N, 11.41. Example 198 4 - ( 4 -Fluoro- 5 -phenyl - lH-pyrazol - l - yl)benzenesulfonamide Step 1; Preparation of 2-fluoroacetophenone To a solution of 2-hydroxyacetophenone (2.5 g, 18.4 mmol) in 100 mL CH2CI2 at -78 * C, was added triflie anhydride (10 g, 35.4 mmol) followed by 2,6-lutidine (4.1 mL, 35.4 mmol) and the mixture stirred at -78"C for 50 minutes. The mixture was poured into CH2CI2 and water and the CH2CI2 layer separated, washed with brine, dried over Na2S04 and concentrated to a peach solid. To a solution of the crude triflate in 100 mL THF was added 35 mL of IN tetrabutylammonium fluoride in THF. The mixture was refiuxed for 15 minutes, cooled and poured into ether and water. The ether layer was separated, washed with brine, dried over Na2S04 and concentrated. Flash chromatography on silica gel using 20:1 hexane/EtOAc furnished the α- fluoroketone (0.852 g, 33.5%). Step 2: Preparation of 4-(4-fluoro-5-phenvl-lH- pvrazol-1-vl)benzenesulfonamide A solution of 2-fluoroacetophenone (200 mg, 1.45 mmol) in 2 mL dimethylformamide-dimethylacetal was refiuxed for 18 hours. The mixture was cooled and concentrated to give the crude enaminoketone. ithout further purification, the enaminoketone was treated with 4- sulfonamidophenyl hydrazine hydrochloride (0.34 g, 1.52 mmol) in 10 mL EtOH at reflux for 17 hours. The mixture was cooled, filtered and the filtrate concentrated to a yellow gum. Flash chromatography using a gradient of 5:1 to 2:1 hexane/EtOAc provided 0.11 g of a yellow solid: Recrystallization from ether/hexane gave the product as a pale yellow solid, mp 194-194.5'C; Anal, calc'd for Cl5Hl2N3θ2SF«0.2 H2θ: C, 56.14; H, 3.89; N, 13.09. Found: C, 55.99; H, 3.65; N, 12.92. Example 199 4- [5- (4-Chlorophenyl) -3- (trifluoromethyl) - 4-chloro-IH-pyrazol-1-yl]benzenesulfonamide A 100 mL three-necked round-bottomed flask equipped with reflux condenser, gas dispersion tube and provisions for magnetic stirring was charged with 4-[5-(4- chlorophenyl)-3-trifluoromethyl-lH-pyrazol-1- yl]benzenesulfonamide (Example 1) (500 mg, 1.2 mmol) and 50 mL of glacial acetic acid. The solution was stirred at room temperature and treated with a stream of chlorine gas for a period of 15 minutes. The solution was then stirred at room temperature for 1.25 hours and then diluted with 100 mL of water. The solution was then extracted three times with ether and the combined ethereal phase washed with brine, dried over MgS04, filtered, and concentrated in vacuo to give a white solid that was recrystallized from ether/petroleum ether to provide 390 mg (75%) of 4-[5-(4- chlorophenyl)-4-chloro-3-trifluoromethyl-lH-pyrazol-l- yl]benzenesulfonamide: mp 180-182°C; 1H NMR (CDCl3/300MHz) 7.97 (d, J=6.6Hz, 2H), 7.49 (d, J=6.3Hz, 2H) , 7.45 (d, J=6.3Hz, 2H) , 7.25 (d, J=6.6Hz, 2H) , 5.78 (brs, 2H) . ) Example 200 4- [ -Fluoro-5-phenyl-3- (trifluoromethyl) -1H- pyrazol-1-yl] enzenesulfonamide Step 1; Preparation of 4.4.4-trifluoro-1-ohenvl- butane-1.3-dione To a solution of 2-fluoroacetophenone from Step 1 of Example 198 (0.48 g, 3.4 mmol) in 25 mL THF at -78 * C, was added IN lithium bis(trimethylsilyl)amide (4 mL,) and the mixture stirred at -78'C for 45 minutes. 1- (Trifluoroacetyl)imidazole (0.65 mL, 5.7 mmol) was added and the mixture stirred at -78 * C for 30 minutes and at 0'C for 30 minutes. The mixture was quenched with 0.5 N HCl, poured into ether and water, and the ether layer separated, washed with brine, dried over a2S04 and concentrated. Flash chromatography on silica gel using a gradient of 10:1 to 4:1 hexane/EtOAc furnished the 1,3-diketone (0.34 g, 43%) . Step 2; Preparation of 4-f4-fluoro-5-phenvl-3- tri luorpmethyl-lH-pyraggl-l- vllbenzenesulfonamide The diketone from Step 1 (0.34 g, 1.45 mmol) was treated with 4-sulfonamidophenyl hydrazine hydrochloride (0.35 g, 1.56 mmol) in 15 mL EtOH at reflux for 15 hours. 5 The mixture was cooled, filtered and the filtrate concentrated to a yellow gum. Flash chromatography using 3:1 hexane/EtOAc provided 0.28 g of a yellow solid. Recrystallization from CH2CI2/hexane gave the product as a pale yellow solid: Anal, calc'd for C16H11N3O2SF : C, ID 49.87; H, 2.88; N, 10.90. Found: C, 49.79; H, 2.88; N, 10.81. Example 201 4- [4-Methyl-5-phenyl-3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide 20 Step 1; Preparation of 2-methvl-l-phenvl-4.4.4- trifluorobutane-1.3-dione To a solution of propiophenone (965 mg, 7.2 mmol) in THF (20 mL) at -78°C was added sodium 25 bis(trimethylsilyl)amide (7.9 mL of a IM solution in THF). The solution was kept at -78°C for 0.5 hour and then warmed to -20°C over 1 hour. The solution was cooled to -78°C and 1- (trifluoroacetyl)imidazole (1.5 g, 9.1 mmol) in THF (4 mL) was added via cannula. The solution was warmed to room 30 temperature and stirred overnight. The mixture was partitioned between IN HCl and ether. The organic solution 97/11704 150 was dried (Na2S04) and concentrated to give the crude diketone (1.9 g) . Step 2; Preparation of 4-f4-methvl-5-phenvl-3- (trifluoromethyl)-lH-Pvrazol-l-vll benzenesulfonamide The diketone from Step 1 was dissolved in absolute ethanol (25 mL) and 4-sulfonamidophenylhydrazine hydrochloride (2.0 g, 9.0 mmol) was added. The mixture was heated at reflux for 19 hours. Volatiles were removed in vacuo and the residue dissolved in ethyl acetate. The organic solution was washed with water and brine, dried and concentrated. The residue was chromatographed on silica (2:1 hexane/ethyl acetate) to give the title pyrazole (1.52 g, 49%): mp 145-146'C; Calc'd for C17H14N3O2SF3: C, 53.54; H, 3.70; N, 11.01. Found: C, 53.41; H, 3.66; N, 10.92. Example 202 4- [4 -Ethyl -5- ( 3 -methyl -4 -methoxyphenyl ) -3- ( trif luoromethyl) -lH-pyrazol-1- yl] benzenesulf onamide Step 1: Preparation of 4-methoxy-3-methvlbutvrophenone: To a suspension of aluminum chloride (10.3 g, 77.2 mmol) in dichloromethane (40 mL) at 0 °C was added 97/11704 dropwise a solution of 2-methylanisole (5.0 mL, 35.3 mmol) and butyric anhydride (5.8 mL, 35.3 mmol). The reaction solution was kept at 0°C for 2 hours and then warmed to room temperature and stirred overnight. The reaction solution was poured into cone. HCl (9 mL) and ice water (80 mL) . The reaction was extracted with dichloromethane and the organic layer was washed with 2N NaOH and brine, dried and concentrated. The residue was chromatographed on silica (9:1 hexane:ethyl acetate) to give the desired product (5.2 g, 77 %) . Ste S 2 and 3; Preparation of 4-f4-ethvl-5-(3-methvl-4- methoxvphenvl)-3-(trifluoromethyl)-1H- pvrazol-1-vllbenzenesulfonamide: The title compound was prepared from the butyrophenone in Step 1 using the procedure described in Example 201, Steps 1 and 2: mp 135-136"C; Calc'd for C20H2ON3O3SF3: C, 54.66; H, 4.59; Ν, 9.56. Found: C, 54.11; H, 4.38; Ν, 9.43. Example 203 4- [4-Cyclopropyl-5-phenyl-3- (trifluoromethyl) IH -pyrazol -1-yl] benzenesulfonamide Step 1: Preparation of 2- vclopropvlacetophenone: To a suspension of sodium cyanide (1.8 g, 37.0 mmol) in dimethyl sulfoxide (20 mL) at 60°C was added dropwise (bromomethy1)cyclopropane (5.0 g, 37.0 mmol). The addition was done at such a rate to keep the temperature of the reaction at 60°C. After the addition was completed, the reaction mixture was heated at 80°C for 15 minutes. The mixture was cooled and partitioned between ether and water. The organic solution was washed with IN HCl and water, dried and concentrated. The residue was dissolved in ether (5 mL) and added to a solution of phenyl magnesium bromide (25 mL of a 3M solution in ether) in ether (20 mL) and benzene (25 mL) . The reaction mixture was stirred at room temperature for 20 hours, then poured into a IN HCl solution and stirred for 1.5 hours. The organic solution was separated and the aqueous solution extracted with dichloromethane. The organic solution was dried and concentrated. The residue was chromatographed on silica (9:1 hexane:ethyl acetate) to give the desired product (2.0 g, 34%) . Steps 2 and 3; Preparation of 4-r4-cvcloproovl-5-phenvl- 3- (trifluoromethyl) -lH-pyrazol-1- yl1benzenesulfonamide: The title compound was prepared from the acetophenone in Step 1 using the procedure described in Example 201), Steps 1 and 2: mp 173-174"C; Calc'd for C19H16N3O2SF3: C, 56.01; H, 3.96; N, 10.31. Found: C, 55.85; H, 3.78; N, 10.19. 7/11704 153 Example 204 4- [4-hydroxymethyl-5-phenyl-3- (trifluoromethyl) - IH-pyrazol-1-yl] enzenesulfonamide Step 1; Preparation of 4-r4-bromomethvl-5-phenvl-3- (trifluoromethyl) -lH-pyrazol-1- vllbenzenesulfonamid : To a solution of 4-[4-methyl-5-phenyl-3- (trifluoromethyl)-lH-pyrazol-1-yl]benzenesulfonamide prepared in Example 201 (500 mg, 1.3 mmol) in carbon tetrachloride (9 mL) and benzene (4 mL) was added N- bromosuccinimide (285 mg, 1.6 mmol). The mixture was irradiated with a sunlamp for 3.5 hours. The reaction mixture was partitioned between dichloromethane and water and the organic solution was dried and concentrated to give the desired product, 412 mg (69%) . Step 2; Preparation of 4-r4-formvl-5-phenvl-3- (trifluoromethvl) -lH-pyrazo -l- vl l benzenesulf onamide : To a solution of the compound prepared in Step 1 (362 mg, 0.79 mmol) in dimethyl sulfoxide (7 mL) was added collidine (0.14 mL, 1.0 mmol). The solution was heated at 120°C for 3 hours and then kept at overnight at room temperature. The reaction solution was partitioned between ethyl acetate and water and the organic solution was washed with water, dried and concentrated. The residue was chromatographed (1:1 hexane.-ethyl acetate) to give the desired product (205 mg, 66%) . Step 3 ; Preparation of 4-r -hvdroxvmethvl-5-phenvl-3- (trifluoromethyl)-lH-pvrazol-1- y 11 nzenesulfonamid ; To a solution of the aldehyde prepared in Step 2 (165 mg, 0.41 mmol) in methanol (3.5 mL) at 0°C was added sodium borohydride (16 mg, 0.41 mmol). The reaction solution was kept at 0°C for 2.5 hours. The reaction was quenched with the addition of an aqueous IM KHSO4 solution (3 mL) . The mixture was extracted with dichloromethane and the organic solution dried and concentrated. The residue was chromatographed on silica (1:1 hexane:ethyl acetate) to give the desired product (36 mg, 46 %) : m.p. 179-180°C; iH NMR d 7.91 (m, 2H) , 7.53-7.40 (m, 5H) , 6.75 (s, 2H) , 4.53 (d, 2h, J = 5.0 Hz), 4.30 (t, IH, J = 5.0 Hz). Example 205 4- (4-Chloro-3-isobutyl-5-phenyl-IH-pyrazol- l-yl)benzenesulfonamide To a solution of the pyrazole prepared in Example 175 (0.15 g, 0.42 mmol) in CH2CI2 (10 mL) was added an excess of sulfuryl chloride slowly at room temperature. The mixture was stirred at room temperature for 2 hours, quenched with water and the aqueous layer extracted three time with methylene chloride. The combined organic layers were dried over MgSθ4 and concentrated to give an oil which was purified by flash chromatography on silica gel using 5 70:30 hexane/ethyl acetate as eluent to give the desired compound: HRMS m/z 389.0970 (calc'd for C19H20CIN3SO2, 389.0965) . The following compounds in Table X were prepared ID according to procedures similar to that examplified in Examples 197-205, with the substitution of the appropriate starting material. TABLE X 5 Ex. R J MP(°C) Analytical 206 Cl H 4-F 175-178 Calc C,51.22; H,3.15; N, 11.94 Obs. C,51.43; H,3.10; N,11.82 207 Br H 4-Cl 209-210 Calc. C,43.66; H,2.69; N,10.18 10 Obs. C43.74; H,2.70; N,10.23 208 Cl H H 172-174 Calc. C,53.98; H,3.62; N,12.59 Cl, 10.62; S, 9.60 Obs. C, 15 209 Cl H 3,5-di-Cl, 4-OCH 3 211-212 Calc. C,44.41; H,2.80; N, 9.71 Obs. C, 44.72; H,3.04, N, 9.72 210 Br H 4-CH 3 ND HRMS : 391.0003 TABLE X (coix .) Ex, R J MP(°C) Analytical 211 Cl H 4-CH 3 160-163 Calc. C, 55.25; H,4.06; N,12.08 Obs. C, 55.06; H,4.03, N, 12.02 212 Cl H 3-Cl, 4-OCH3 ND Calc. C,48.25; H,3.29; N,10.55 10 Cl, 17.80; S, 8.05 Obs. C,48.10; H,3.31, N, 10.52 Cl, 17.70; S, 7.98 213 Cl H 4-OCH3 155-156 Calc. C, 52.82; H,3.88; N, 11.55 Obs. C52.18; H,3.93, N, 11.41 15 214 Br H 4-OCH3 130-132 215 CN H 4-OCH3 216-219 HRMS: 355.0860 TABLE X (cont . ) Ex . R " R' MP (°C ) Analytical 0 216 Cl H 3,5-di-F, 4-OCH 3 198-199 Calc. C,48.07; H, 3.03; N,10.51 Obs. C,48.45; H, 3.55, N, 10.10 217 SO2CH3 H Cl 182-185 Calc. C,46.66; H,3.43; N, 10.20 10 Obs. C,46.57; H, 3.49, N, 10.39 218 C2H5 CF3 H 177-178 Calc. C, 54.68; H, 4.08; N, 10.62 Obs. C, 54.61; H, 4.10; N, 10.54 219 CH 3 CF3 4-OCH 3 158-159 Calc. C, 52.55; H, 3.92; N, 10.21 Obs. C, 52.27; H, 4.00; N, 10.16 15 220 CH3 CF3 4-Cl 154-155 Calc. C, 49.10; H, 3.15; N, 10.10 Obs. C, 49.05; H, 3.02; N, 9.96 221 CH 3 CF3 4-F 103-104 Calc. C, 51.13; H, 3.28; N, 10.52 Obs. C, 51.09; H, 3.26; N, 10.34 TABLE X (cont.) Ex. R- MP(°C) Analytical in 10 4-Cl ND Calc. C, 50.30; H, 3.52; N, 9.77 Obs. C, 50.40; H, 3.51; N, 9.72 4-CH 3 144-145 Calc. C, 54.68; H, 4.08; N, 10.62 10 Obs. C, 54.38; H, 3.87; N, 10.31 4-CH 3 142-143 Calc. C, 55.74; H, 4.43; N, 10.26 Obs. C, 55.60; H, 4.37; N, 10.17 4-OCH 3 160-161 Calc. C, 53.64; H, 4.26; N, 9.87 Obs. C, 53.55; H, 4.23; N, 9.65 15 3-F, 4-OCH 3 156-157 Calc. C, 51.46; H, 3.86; N, 9.47 Obs. C, 51.27; H, 3.75; N, 9.33 4-Cl 224-226 Calc. C, 41.53; H, 2.40; N,9.08 Obs. C, 41.50; H, 2.38; N, 9.00 TABLE X (cont.) Ex, R- MP(°C) Analytical 92-102 (dec) Calc C, 42.30; H, 2.51; N, 8.70 Obs. C, 42.50; H, 2.67, N, 8.56 174-176 Calc. C,50.07; H, 3.15; N, 10.95 10 Obs. C, 50.07; H,3.18, N, 10.98 184-186 Calc C, 44.87; H, 2.82; N, 9.81 Obs. C, 44.98; H, 2.81, N, 9.64 171-172 HRMS: 413.0351 174-177 (sub) Calc. C,53.56; H, 3.09; N,15.61; 15 Cl, 9.98; S, 8.94 Obs. C, 53.81; H, 3.18; N, 15.43; Cl, 9.78; S, 8.91 TABLE X (cont.) Ex. R J MP(°C) Analytical σ> 233 Cl CN 4-Cl ND Calc. C, 48.87; H,2.56; N, 14.25; Cl, 18.03; S, 8.15 Obs. C, 48.99; H, 2.55; N, 14.30; 10 Cl, 17.96; S, 8.08 234 Cl CN 4-F ND Calc. C51.00; H, 2.68; N, 14.87; Cl, 9.41; S, 8.51 Obs. C, 51.19; H, 2.73; N, 14.98 ; Cl, 9.22; Ξ, 8.56 15 235 Br CN 4-F ND Calc. C,45.62; H, 2.39; N, 13.30 ; Br, 18.97; S, 7.61 Obs. C, 45.51; H,2.36; N, 13.21 ; Br, 19.09; S, 7.51 TABLE X (cont.) Ex. R J MP{°C) Analytical 236 Br CN H ND Calc. C,47.66; H, 2.75; N, 13.89; Br, 19.81; S, 7.95 Obs. C, 47.62; H, 2.77; N, 13.77 ; 10 Br, 19.74; S, 8.04 ND HRMS: 482.9707 ND HRMS: 342.0495 ND HRMS: 426.0128 ND HRMS: 440.0207 15 ND HRMS: 410.0391 ND HRMS: 453.9880 TABLE X (cont.) Ex. R " MP(°C) Analytical oo 243 Cl C0 2 CH 3 4-OCH 3 , 3-Cl ND Calc. C, 47.38; H, 3.31; N, 9.21; Cl, 15.54; S, 7.03 Obs. C, 47.10; H, 3.26; N, 9.01; 10 Cl, 15.74; S, 6.92 198-199 Calc. C, 44.06; H,2.88; N, 8.56. Obs. C, 43.59; H,2.77; N, 8.44 ND Calc. C, 43.18, H, 3.02; N, 8.39; S, 6.40 15 Obs. C, 43.25; H, 2.97; N, 8.40; S, 6.59 HRMS: 377.0539 HRMS: 411.0115 TABLE X (cont.) Ex. R- MP(°C) Analytical J HRMS: 395.0397 Calc. C, 43.75, H, 2.75; N, 12.75; Br, 18.19; S, 7.30 10 Obs. C, 43.65; H, 2.78; N, 12.66; Br, 18.13; S, 7.21 HRMS: 419.9920 HRMS 377.0249 Calc. C, 46.62, H, 2.69; N, 10.19; 15 Cl, 17.20; S, 7.78 Obs. C, 46.59, H, 2.68; N, 10.21; Cl, 17.25; S, 7.73 TABLE X (cont.) Ex. R " MP(°C) Analytical 3 , 3,5-di-Cl 220 (dec) Calc. C, 42.83; H, 2.54; N,8.81 Obs. C, 43.65; H, 2.52; N, 8.78 ND Calc. C, 55.25; H, 4.06; N, 12.08 10 Obs. C,55.24; H,4.26; N, 12.17 195-197 HRMS: 363.0431 203-204 Calc. C,48.25; H,3.29; N, 10.55 Obs. C, 48.36; H,3.27; N, 10.50 212-214 Calc. C, 49.10; H, 3.43; N, 9.54 15 Obs. C, 49.23; H, 3.45; N, 9.49 137-138 Calc. C51.38; H, 3.55; N,10.57 Obs. C, 51.40; H, 3.47; N, 10.47 Example 259 4- [ -Chloro- 3 -cyano- 5- [4- ( fluoro) henyl ] ) -1H- pyrazol-1-yl] -N- [ (dimethylamino ) methylene] benzenesulfonamide Increasing the polarity of the eluant used in the purification in Example 234 to 60% ethyl acetate, upon concentration of the appropriate fractions, yielded 4- [4- chloro-3-cyano-5- [4- (fluoro) phenyl] ) -IH-pyrazol-l-yl] -N- [ (dimethylamino) methylene] benzenesulfonamide (0.485 g, 15%) : High Resolution Mass Spectrum (MLi+) calc'd: 438.0779. Found: 438.0714. Elemental analysis calc'd for C 19 H 15 N 5 O 2 FCIS: C, 52.84: H, 3.50: N, 16.22; Cl, 8.21; S, 7.42. Found: C, 52.76; H, 3.52; N, 16.12; Cl, 8.11; S, 7.35. Example 260 4- [4-Bromo-3-cyano-5-phenyl-lH-pyrazol-l-yl] -N- [ (dimethylamino)methylene]benzenesulfonamide Similarly, 4-[4-bromo-3-cyano-5-phenyl-lH-pyrazol-l- yl]-N-[ (dimethylamino)methylene] benzenesulfonamide was isolated from the purification of Example 235 (0.153 g, 28%): High Resolution Mass Spectrum (M+) calc'd: 457.0208. Found: 457.0157. Elemental analysis calc'd for CιgHi 6 N 5 θ 2 BrS: C, 49.79: H, 3.52: N, 15.28; Br, 17.43; S, 6.99. Found: C, 49.85; H, 3.56; N, 15.10; Br, 17.52; S, 6.87. Example 261 4- [1- (4-Fluorophenyl) -3- (trifluoromethyl) - lH-pyrazol-5-yl]benzenesulfonamide Step 1; Preparation of N.N-bis(4-methoxvbenzvl) -4- (aminosulfonyl)acetophenone . To a solution of 4- (aminosulfonyl)acetophenone (2.0g, 9.0 mmol) in dimethylsulfoxide (25 mL) was added sodium hydride (450 mg, 19.0 mmol). The reaction mixture was stirred for 45 minutes and then 4-methoxybenzyl bromide (3.5 g, 19.0 mmol) in dimethylsulfoxide (5 mL) was added via cannula. The mixture was stirred at room temperature for 24 hours and partitioned between ethyl acetate and pH 7 buffer. The aqueous solution was extracted with ethyl acetate. The organic solution was dried (MgS04) and concentrated. The residue was chromatographed on silica (2:1 hexane:ethyl acetate) to give the desired product (815 mg, 21%) . Step 2 : Preparation of N.N-bis(4-methoxybenzyl) -4- ri- (4-fluorophenyl)-3-trifluoromethyl-lH- pvrazol-5-vπbenzenesulfonamide To a 25% sodium methoxide solution in methanol (0.2 mL) was added ethyl trifluoroacetate (75 mg, 0.53 mmol) and the protected acetophenone from Step 1 (235 mg, 0.53 mmol). THF (0.5 mL) was added and the reaction mixture was heated at reflux for 2 hours and then stirred at room temperature overnight. The mixture was partitioned between ether and IN HCl solution. The organic solution was dried and concentrated to give the crude diketone (279 mg) , which was diluted with absolute ethanol (2.5 mL) . To this slurry was added pyridine (49 mg, 0.62 mmol) and 4-fluorophenylhydrazine hydrochloride (80 mg, 0.50 mmol). The mixture was stirred at room temperature for 24 hours and concentrated in vacuo . The residue was dissolved in methylene chloride and washed with IN HCl. The organic solution was dried and concentrated. The residue was chromatographed on silica (3:1 hexane:ethyl acetate) to give the protected pyrazole (159 mg, 51%) . Step 3: Preparation of 4-ri-(4-fluorophenyl) -3- trifluoromethyl-lH-pvrazol-5- vl1benzenesulfonamide. To a solution of the protected pyrazole (50 mg, 0.08 mmol) in acetonitrile (1 mL) and water (0.3 mL) was added eerie ammonium nitrate (360 mg, 0.65 mmol). The reaction solution was kept at room temperature for 16 hours. The solution was poured into water (15 mL) and extracted with ethyl acetate (2 x 25 mL) . The combined extracts were dried (MgS04) and concentrated. The residue was chromatographed on silica (2:1 hexane:ethyl acetate) to give the desired product (13 mg, 42%) : -i-H NMR (CD3OD) 7.88 (d,2H), 7.46 (d, 2H) , 7.39 (dd, 2H) , 7.21 (t, 2H) , 7.06 (s, IH) . Example 262 4 - [ 1 - ( -methoxyphenyl ) - 3 - ( tri f luoromethyl ) - IH- pyra zol - 5 -yl] benzenesulfonamide The title compound was prepared using the procedure described in Example 261 : HRMS m/ z 397 . 0702 (calc ' d for C17H14N3O3SF3 , 397 . 0708 ) . B IOLOGICAL EVALUATION Rat Carrageenan Foot Pad Edema Test The carrageenan foot edema test was performed with materials, reagents and procedures essentially as described by Winter, et al., { Proc . Soc. Exp. Biol . Med. , Ill, 544 (1962)). Male Sprague-Dawley rats were selected in each group so that the average body weight was as consistant as possible. Rats were fasted with free access to water for over sixteen hours prior to the test. The rats were dosed orally (1 mL) with compounds suspended in vehicle containing 0.5% methylcellulose and 0.025% surfactant, or with vehicle alone. One to two hours later a subplantar injection of 0.1 mL of 1% solution of carrageenan/sterile 0.9% saline was administered and the volume of the injected foot was measured with a displacement plethysmometer connected to a pressure transducer with a digital indicator. Three hours after the injection of the carrageenan, the volume of the foot was again measured. The average foot swelling in a group of drug-treated animals was compared with that of a group of placebo-treated animals and the percentage inhibition of edema was determined (Otterness and Bliven, Laboratory Models for Testing NSAIDs, in Non-steroidal Anti-Inflammatory Drugs, (J. Lombardino, ed. 1985) ) . The % inhibition shows the % decrease from control paw volume determined in this procedure and the data for selected compounds in this invention are summarized in Table I. Rat Carrageenan-induced Analgesia Test The analgesia test using rat carrageenan was performed with materials, reagents and procedures essentially as described by Hargreaves, et al. , (Pain, 32, 77 (1988)). Male Sprague-Dawley rats were treated as previously described for the Carrageenan Foot Pad Edema test. Three hours after the injection of the carrageenan, the rats were placed in a special plexiglass container with a transparent floor having a high intensity lamp as a radiant heat source, positionable under the floor. After an initial twenty minute period, thermal stimulation was begun on either the injected foot or on the contralateral uninjected foot. A photoelectric cell turned off the lamp and timer when light was interrupted by paw withdrawal. The time until the rat withdraws its foot was then measured. The withdrawal latency in seconds was determined for the control and drug-treated groups, and percent inhibition of the hyperalgesic foot withdrawal determined. Results are shown in Table XI. TABLE X . RAT PAW EDEMA ANALGESIA % Inhibition % Inhibition @ lOmσ/kσ body weight @ 30mσ/kσ bodv weight Examples 1 44 94 2 35 38 58 36 65 59 25 41 60 49 39 82 22* 86 42* 98 2* 117 32 129 47* 170 18* 171 14 37 188 32* 197 45* 27 199 35 .* Assay performed at 30 mg/kg bodv weight Evaluation of COX I and COX II activity in vi tro The compounds of this invention exhibited inhibition in vitro of COX II. The COX II inhibition activity of the compounds of this invention illustrated in the Examples was determined by the following methods. a. Preparation of recombinant COX baculoviruses A 2.0 kb fragment containing the coding region of either human or murine COX-I or human or murine COX-II was cloned into a BamHI site of the baculovirus transfer vector pVLl393 (Invitrogen) to generate the baculovirus transfer vectors for COX-I and COX-II in a manner similar to the method of D.R. O'Reilly et al (Baculovirus Expression Vectors : A Labora tory Manual (1992)). Recombinant baculoviruses were isolated by transfecting 4 μg of baculovirus transfer vector" DNA into SF9 insect cells (2xl0e8) along with 200 ng of linearized baculovirus plasmid DNA by the calcium phosphate method. See M.D. Summers and G.E. Smith, A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures, Texas Agric. Exp. Station Bull. 1555 (1987). Recombinant viruses were purified by three rounds of plaque purification and high titer (10E7 - 10E8 pfu/ml) stocks of virus were prepared. For large scale production, SF9 insect cells were infected in 10 liter fermentors (0.5 x 10^/ml) with the recombinant baculovirus stock such that the multiplicity of infection was 0.1. After 72 hours the cells were centrifuged and the cell pellet homogenized in Tris/Sucrose (50 mM: 25%, pH 8.0) containing 1% 3-[(3- cholamidopropyl)dime hylammonio] -1-propanesulfonate (CHAPS). The homogenate was centrifuged at 10,000xG for 30 minutes, and the resultant supernatant was stored at -80°C before being assayed for COX activity. b. Assay for COX I and COX II activity: COX activity was assayed as PGE 2 formed/μg protein/time using an ELISA to detect the prostaglandin released. CHAPS-solubilized insect cell membranes containing the appropriate COX enzyme were incubated in a potassium phosphate buffer (50 mM, pH 8.0) containing epinephrine, phenol, and.heme with the addition of arachidonic acid (10 μM) . Compounds were pre-incubated with the enzyme for 10-20 minutes prior to the addition of arachidonic acid. Any reaction between the arachidonic acid and the enzyme was stopped after ten minutes at 37°C/room temperature by transferring 40 μl of reaction mix into 160 μl ELISA buffer and 25 μM indomethacin. The PGE 2 formed was measured by standard ELISA technology (Cayman Chemical) . Results are shown in Table XII. TABLE XII ( cont . ) Also embraced within this invention is a class of pharmaceutical compositions comprising the active compounds of this combination therapy in association with one or more non-toxic, pharmaceutically-acceptable carriers and/or diluents and/or adjuvants (collectively referred to herein as "carrier" materials) and, if desired, other active ingredients. The active compounds of the present invention may be administered by any suitable route, preferably in the form of a pharmaceutical composition adapted to such a route, and in a dose effective for the treatment intended. The active compounds and composition may, for example, be administered orally, intravascularly, intraperitoneally, subcutaneously, intramuscularly or topically. For oral administration, the pharmaceutical composition may be in the form of, for example, a tablet, capsule, suspension or liquid. The pharma¬ ceutical composition is preferably made in the form of a dosage unit containing a particular amount of the active ingredient. Examples of such dosage units are tablets or capsules. The active ingredient may also be admin¬ istered by injection as a composition wherein, for example, saline, dextrose or water may be used as a suitable carrier. The amount of therapeutically active compounds that are administered and the dosage regimen for treating a disease condition with the compounds and/or compositions of this invention depends on a variety of factors, including the age, weight, sex and medical condition of the subject, the severity of the disease, the route and frequency of administration, and the particular compound employed, and thus may vary widely. The pharmaceutical compositions may contain active ingredients in the range of about 0.1 to 2000 mg, preferably in the range of about 0.5 to 500 mg and most preferably between about 1 and 100 mg. A daily dose of about 0.01 to 100 mg/kg body weight, preferably between about 0.5 and about 20 mg/kg body weight and most preferably between about 0.1 to 10 mg/kg body weight, may be appropriate. The therapeutically active compounds can be administered on an as needed basis. Alternatively, the therapeutically active compounds can be administered at a once a week, once a month, or other suitable frequency, based on the formulation, compound half life, administration substantially simultaneous with feeding, age of animal, and other related properties. A daily dose can be administered in one to four doses per day. In the case of skin conditions, it may be preferable to apply a topical preparation of compounds of this invention to the affected area two to four times a day. For inflammations of the eye or other external tissues, e.g., mouth and skin, the formulations are preferably applied as a topical ointment or cream, or as a suppository, containing the active ingredients in a total amount of, for example, 0.075 to 30% w/w, preferably 0.2 to 20% w/w and most preferably 0.4 to 15% w/w. When formulated in an ointment, the active ingredients may be employed with either paraffinic or a water-miscible ointment base. Alternatively, the active ingredients may be formulated in a cream with an oil-in- water cream base. If desired, the aqueous phase of the cream base may include, for example at least 30% w/w of a polyhydric alcohol such as propylene glycol, butane- 1,3-diol, mannitol, sorbitol, glycerol, polyethylene glycol and mixtures thereof. The topical formulation may desirably include a compound which enhances absorption or penetration of the active ingredient through the skin or other affected areas. Examples of such dermal penetration enhancers include dimethylsulfoxide and related analogs. The oily phase of the emulsions of this invention may be constituted from known ingredients in a known manner. While the phase may comprise merely an emulsifier, it may comprise a mixture of at least one emulsifier with a fat or an oil or with both a fat and an oil. Preferably, a hydrophilic emulsifier is included together with a lipophilic emulsifier which acts as a stabilizer. It is also preferred to include both an oil and a fat. Together, the emulsifier(s) with or without stabilizer(s) make-up the so-called emulsifying wax, and the wax together with the oil and fat make up the so-called emulsifying ointment base which forms the oily dispersed phase of the cream formulations. Emulsifiers and emulsion stabilizers suitable for use in the formulation of the present invention include Tween 60, Span 80, cetostearyl alcohol, myristyl alcohol, glyceryl monostearate, and sodium lauryl sulfate, among others. The choice of suitable oils or fats for the formulation is based on achieving the desired cosmetic properties, since the solubility of the active compound in most oils likely to be used in pharmaceutical emulsion formulations is very low. Thus, the cream should preferably be a non-greasy, non-staining and washable product with suitable consistency to avoid leakage from tubes or other containers. Straight or branched chain, mono- or dibasic alkyl esters such as di-isoadipate, isocetyl stearate, propylene glycol diester of coconut fatty acids, isopropyl myristate, decyl oleate, isopropyl palmitate, butyl stearate, 2- ethylhexyl palmitate or a blend of branched chain esters may be used. These may be used alone or in combination depending on the properties required. Alternatively, high melting point lipids such as white soft paraffin and/or liquid paraffin or other mineral oils can be used. Formulations suitable for topical administration to the eye also include eye drops wherein the active ingredients are dissolved or suspended in suitable carrier, especially an aqueous solvent for the active ingredients. The antiinflammatory active ingredients are preferably present in such formulations in a concentration of 0.5 to 20%, advantageously 0.5 to 10% and particularly about 1.5% w/w. For therapeutic purposes, the active compounds of this combination invention are ordinarily combined with one or more adjuvants appropriate to the indicated route of administration. If administered per os , the compounds may be admixed with lactose, sucrose, starch powder, cellulose esters of alkanoic acids, cellulose alkyl esters, talc, stearic acid, magnesium stearate, magnesium oxide, sodium and calcium salts of phosphoric and sulfuric acids, gelatin, acacia gum, sodium alginate, polyvinylpyrrolidone, and/or polyvinyl alcohol, and then tableted or encapsulated for con¬ venient administration. Such capsules or tablets may contain a controlled-release formulation as may be provided in a dispersion of active compound in hydroxy- propyImethyl cellulose. Formulations for parenteral administration may be in the form of aqueous or non- aqueous isotonic sterile injection solutions or suspensions. These solutions and suspensions may be prepared from sterile powders or granules having one or more of the carriers or diluents mentioned for use in the formulations for oral administration. The compounds may be dissolved in water, polyethylene glycol, propylene glycol, ethanol, corn oil, cottonseed oil, peanut oil, sesame oil, benzyl alcohol, sodium chloride, and/or various buffers. Other adjuvants and modes of administration are well and widely known in the pharmaceutical art. Although this invention has been described with respect to specific embodiments, the details of these embodiments are not to be construed as limitations.

Claims: What is claimed is: 1. A method of treating inflammation or an inflammation-associated disorder in an animal, said method comprising administering to the animal having or susceptible to such inflammation or inflammation- associated disorder, a therapeutically-effective amount of a compound of Formula I wherein R^ is selected from aryl and heteroaryl, wherein R^ is substituted at a substitutable position with one or more radicals selected from sulfamyl, halo, alkyl, alkoxy, hydroxyl, haloalkyl and wherein R^ is selected from hydrido, halo, alkyl, haloalkyl, cyano, nitro, formyl, carboxyl, alkoxy, aminocarbonyl, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, amidino, cyanoamidino, cyanoalkyl, alkoxycarbonylcyanoalkenyl, aminocarbonylalkyl, N- alkylaminocarbonyl, N-arylaminocarbonyl, N,N- dialkylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, cycloalkylaminocarbonyl, heterocyclicaminocarbonyl, carboxyalkylaminocarbonyl, aralkoxycarbonylalkylaminocarbonyl, alkylcarbonyl, alkylcarbonylalkyl, hydroxyalkyl, haloaralkyl, carboxyhaloalky1, alkoxycarbonylhaloalky1, aminocarbonylhaloalkyl, alkylaminocarbonylhaloalkyl, N- alkylamino, N,N-dialkylamino, N-arylamino, N- aralkylamino, N-alkyl-N-aralkylamino, N-alkyl-N- arylamino, aminoalkyl, N-alkylaminoalkyl, N,N- dialkylaminoalkyl, N-arylaminoalkyl, N- aralkylaminoalkyl, N-alkyl-N-aralkylaminoalkyl, N- alkyl-N-arylaminoalkyl, aryloxy, aralkoxy, arylthio, aralkylthio, alkylthio, alkylsulfinyl, alkylsulfonyl, N-alkylaminosulfonyl, N-arylaminosulfonyl, arylsulfonyl, N,N-dialkylaminosulfonyl, N-alkyl-N- arylaminosulfonyl, heterocyclic, wherein R^ is selected from hydrido, alkyl, halo, haloalkyl, cyano, nitro, formyl, carboxyl, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl, amidino, cyanoamidino, aminocarbonyl, alkoxy, N- alkylamino, N,N-dialkylamino, aminocarbonylalkyl, N- alkylaminocarbonyl, N-arylaminocarbonyl, N,N- dialkylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, alkylcarbonyl, alkylcarbonylalkyl, hydroxyalkyl, alkylthio, alkylsulfinyl, alkylsulfonyl, N- alkylaminosulfonyl, N-arylaminosulfonyl, arylsulfonyl, N,N-dialkylaminosulfonyl, N-alkyl-N-arylaminosulfonyl, cycloalkyl, heterocyclic, heterocyclicalkyl and aralkyl; wherein R^ is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R 4 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkyl, alkenyl, alkylsulfonyl, cyano, carboxyl, alkoxycarbonyl, aminocarbonyl, N-alkylaminocarbonyl, N- arylaminocarbonyl, N,N-dialkylaminocarbonyl, N-alkyl-N- arylaminocarbonyl, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, haloalkoxy, sulfamyl, N- alkylaminosulfonyl, amino, N-alkylamino, N,N- dialkylamino, heterocyclic, cycloalkylalkyl, nitro, acylamino, or wherein R3 and R 4 together form (CH 2 ), R' wherein m is 1 to 3, inclusive; wherein A is selected from phenyl and five or six membered heteroaryl; wherein R 5 is alkyl; wherein R^ is one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkylsulfonyl, cyano, carboxyl, alkoxycarbonyl, aminocarbonyl, N- alkylaminocarbonyl, N-arylaminocarbonyl, alkyl, alkenyl, N,N-diaIkylaminocarbonyl, N-alkyl-N- arylaminocarbonyl, haloalkyl, hydrido, hydroxyl, alkoxy, hydroxyalkyl, haloalkoxy, sulfamyl, N- alkylaminosulfonyl, amino, N-alkylamino, N,N- dialkylamino, heterocyclic, cycloalkylalkyl, nitro and acylamino; and wherein R 7 is selected from hydrido, alkyl, aryl and aralkyl; or a pharmaceutically-acceptable salt thereof. 2. The method of Claim 1 wherein R^- is selected from aryl selected from phenyl, naphthyl and biphenyl, and five- or six-membered heteroaryl, wherein R-i- is substituted at a substitutable position with one or more radicals selected from sulfamyl, halo, lower alkyl, lower alkoxy, hydroxyl, lower haloalkyl and wherein R2 is selected from hydrido, halo, lower alkyl, lower haloalkyl, cyano, nitro, formyl, carboxyl, lower alkoxycarbonyl, lower carboxyalkyl, lower alkoxycarbonylalkyl, amidino, cyanoamidino, lower cyanoalkyl, lower alkoxycarbonylcyanoalkenyl, aminocarbonyl, lower alkoxy, lower aryloxy, lower aralkoxy, lower aminocarbonylalkyl, lower N- alkylaminocarbonyl, N-arylaminocarbonyl, lower N,N- dialkylaminocarbonyl, lower N-alkyl-N- arylaminocarbonyl, lower cycloalkylaminocarbonyl, lower heterocyclicaminocarbonyl, lower carboxyalkylaminocarbonyl, lower aralkoxycarbonylalkylaminocarbonyl, lower haloaralkyl, lower carboxyhaloalkyl, lower alkoxycarbonylhaloalkyl, lower aminocarbonylhaloalkyl, lower alkylaminocarbonylhaloalkyl, lower alkylcarbonyl, lower alkylcarbonylalkyl, lower alkylamino, lower N,N- dialkylamino, N-arylamino, lower N-aralkylamino, lower N-alkyl-N-aralkylamino, lower N-alkyl-N-arylamino, lower aminoalkyl, lower N-alkylaminoalkyl, lower N,N- dialkylaminoalkyl, lower N-arylaminoalkyl, lower N- aralkylaminoalkyl, lower N-alkyl-N-aralkylaminoalkyl, lower N-alkyl-N-arylaminoalkyl, arylthio, lower aralkylthio, lower hydroxyalkyl, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower N- alkylaminosulfonyl, N-arylaminosulfonyl, arylsulfonyl, lower N,N-dialkylaminosulfonyl, lower N-alkyl-N- arylaminosulfonyl, heterocyclic, ? 7 f R 7 .^N Ns ^ NH 2 / > ^ N VS ^ NH 2 t ^^" C E 3 , s wherein R3 is selected from hydrido, lower alkyl, halo, lower haloalkyl, cyano, nitro, formyl, carboxyl, lower alkoxycarbonyl, lower carboxyalkyl, lower alkoxycarbonylalkyl, amidino, cyanoamidino, aminocarbonyl, lower alkoxy, lower N-alkylamino, lower N,N-dialkylamino, lower aminocarbonylalkyl, lower N- alkylaminocarbonyl, lower N-arylaminocarbonyl, lower N,N-dialkylaminocarbonyl, lower N-alkyl-N- arylaminocarbonyl, lower alkylcarbonyl, lower alkylcarbonylalkyl, lower hydroxyalkyl, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower N-alkylaminosulfonyl, N-arylaminosulfonyl, arylsulfonyl, lower N,N-dialkylaminosulfonyl, lower N- alkyl-N-arylaminosulfonyl, lower cycloalkyl, heterocyclic, lower heterocyclicalkyl and lower aralkyl; wherein R 4 is selected from lower aralkenyl, aryl, lower cycloalkyl, lower cycloalkenyl and five to ten membered heterocyclic; wherein R 4 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, lower alkenyl, lower alkylsulfonyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower N-alkylaminocarbonyl, N- arylaminocarbonyl, lower N,N-dialkylaminocarbonyl, lower N-alkyl-N-arylaminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, sulfamyl, lower N-alkylaminosulfonyl, amino, lower N-alkylamino, lower N,N-dialkylamino, five- or six-membered heterocyclic, lower cycloalkylalkyl, nitro, acylamino, R 7 R 7 "Υ^ 2 , and ^ NH 2 ; 0 S or wherein R^ and R 4 together form wherein m is 1 to 3 , inclusive; wherein A is selected from phenyl and five or six membered heteroaryl; wherein R 5 is lower alkyl; wherein R^ is one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower Ν- alkylaminocarbonyl, Ν-arylaminocarbonyl, lower alkyl, lower alkenyl, lower Ν,Ν-dialkylaminocarbonyl, lower N- alkyl-N-arylaminocarbonyl, lower haloalkyl, hydrido, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, sulfamyl, lower N-alkylaminosulfonyl, amino, lower N-alkylamino, lower N,N-dialkylamino, five- or six membered heterocyclic, lower cycloalkylalkyl, nitro and acylamino; and wherein R 7 is selected from hydrido, lower alkyl, aryl and lower aralkyl; or a pharmaceutically-acceptable salt thereof. 3. The method of Claim 2 wherein R^ is phenyl, wherein R^ is substituted at a substitutable position with one or more radicals selected from sulfamyl, halo, lower alkyl, lower alkoxy, hydroxyl, lower haloalkyl and wherein R^ is selected from hydrido, lower alkyl, lower haloalkyl, cyano, carboxyl, lower alkoxycarbonyl, lower carboxyalkyl, lower cyanoalkyl, lower alkoxycarbonylcyanoalkenyl, lower haloaralkyl, lower carboxyhaloalkyl, lower alkoxycarbonylhaloalkyl, lower aminocarbonylhaloalkyl, lower alkylaminocarbonylhaloalkyl, lower N-alkylamino, lower N,N-dialkylamino, N-arylamino, lower N-aralkylamino, lower N-alkyl-N-aralkylamino, lower N-alkyl-N- arylamino, lower aminoalkyl, lower N-alkylaminoalkyl, lower N,N-dialkylaminoalkyl, lower N-arylaminoalkyl, lower N-aralkylaminoalkyl, lower N-alkyl-N- aralkylaminoalkyl, lower N-alkyl-N-arylaminoalkyl, aryloxy, lower aralkoxy, lower alkoxy, lower alkylthio, arylthio, lower aralkylthio, aminocarbonyl, lower aminocarbonylalkyl, lower N-alkylaminocarbonyl, N- arylaminocarbonyl, lower N,N-dialkylaminocarbonyl, lower N-alkyl-N-arylaminocarbonyl, lower cycloalkylaminocarbonyl, lower carboxyalkylaminocarbonyl, lower aralkoxycarbonylalkylaminocarbonyl, lower hydroxyalkyl, wherein R^ is selected from hydrido, lower alkyl, halo, cyano, lower hydroxyalkyl, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower alkoxy, lower N-alkylamino, lower N,N-dialkylamino, lower N- alkylaminosulfonyl, N-arylaminosulfonyl, arylsulfonyl, lower N,N-dialkylaminosulfonyl, lower N-alkyl-N- arylaminosulfonyl and lower cycloalkyl; wherein R 4 is selected from lower aralkenyl, aryl, lower cycloalkyl, lower cycloalkenyl and five to ten membered heterocyclic; wherein R 4 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, lower alkenyl, lower alkylsulfonyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, sulfamyl, lower alkylaminosulfonyl, amino, lower N-alkylamino, lower N,N-dialkylamino, five or six membered heterocyclic, lower cycloalkylalkyl, nitro, or wherein R^ and R 4 together form wherein m is 2; wherein A is selected from phenyl and five or six membered heteroaryl; wherein R 5 is lower alkyl; wherein R^ is one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, lower alkenyl, lower alkylsulfonyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, sulfamyl, amino, lower N-alkylamino, lower N,N-dialkylamino, lower cycloalkylalkyl and nitro; and wherein R 7 is selected from hydrido, lower alkyl, aryl and lower aralkyl; or a pharmaceutically- acceptable salt thereof. 4. The method of Claim 3 wherein R1 is phenyl, wherein R-i- is substituted at a substitutable position with one or more radicals selected from sulfamyl, halo, lower alkyl, lower alkoxy and wherein R 2 is selected from hydrido, lower alkyl, lower haloalkyl, cyano, carboxyl, lower alkoxycarbonyl, lower carboxyalkyl, lower cyanoalkyl, lower alkoxycarbonylcyanoalkenyl, lower haloaralkyl, lower carboxyhaloalkyl, lower alkoxycarbonylhaloalkyl, lower aminocarbonylhaloalkyl, lower alkylaminocarbonylhaloalkyl, lower N-alkylamino, lower N,N-dialkylamino, N-arylamino, lower N-aralkylamino, lower N-alkyl-N-aralkylamino, lower N-alkyl-N- arylamino, lower aminoalkyl, lower N-alkylaminoalkyl, lower N,N-dialkylaminoalkyl, lower N-arylaminoalkyl, lower N-aralkylaminoalkyl, lower N-alkyl-N- aralkylaminoalkyl, lower N-alkyl-N-arylaminoalkyl, lower alkoxy, aryloxy, lower aralkoxy, lower alkylthio, arylthio, lower aralkylthio, aminocarbonyl, lower aminocarbonylalkyl, lower N-alkylaminocarbonyl, N- arylaminocarbonyl, lower N,N-dialkylaminocarbonyl, lower N-alkyl-N-arylaminocarbonyl, lower cycloalkylaminocarbonyl, lower carboxyalkylaminocarbonyl, lower heterocyclicaminocarbonyl, lower aralkoxycarbonylalkylaminocarbonyl, lower hydroxyalkyl, ? 7 f R 7 X / ^^ , ^^N^,NH 2 f \ /N CH3 , wherein R3 is selected from hydrido, lower alkyl, halo, cyano, lower hydroxyalkyl, lower alkoxy, lower N- alkylamino, lower N,N-dialkylamino, lower alkylthio, lower alkylsulfonyl and lower cycloalkyl; wherein R 4 is selected from lower aralkenyl, aryl, lower cycloalkyl, lower cycloalkenyl and five to ten membered heterocyclic; wherein R 4 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, lower alkenyl, lower alkylsulfonyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, sulfamyl, amino, lower N-alkylamino, lower N,N-dialkylamino, five or six membered heterocyclic, lower cycloalkylalkyl, nitro, or wherein R^ and R 4 together form (CH 2 ) m R 1 '-' wherein m is 2; wherein A is selected from phenyl and five membered heteroaryl; wherein R 5 is lower alkyl; wherein R^ is one or more radicals selected from halo, lower alkyl, lower alkylsulfonyl, lower haloalkyl, lower alkoxy, sulfamyl, amino and nitro; and wherein R 7 is selected from hydrido, lower alkyl, aryl and lower aralkyl; or a pharmaceutically-acceptable salt thereof. 5. The method of Claim 4 wherein R^ is phenyl substituted at a substitutable position with one or more radicals selected from halo, lower alkyl, sulfamyl and wherein R 2 is selected from hydrido, lower alkyl, lower haloalkyl, cyano, carboxyl, lower alkoxycarbonyl, lower carboxyalkyl, lower cyanoalkyl, lower alkoxycarbonylcyanoalkenyl, lower haloaralkyl, lower carboxyhaloalkyl, lower alkoxycarbonylhaloalkyl, lower aminocarbonylhaloalkyl, lower alkylaminocarbonylhaloalkyl, lower N-alkylamino, lower N,N-dialkylamino, N-arylamino, lower N-aralkylamino, lower N-alkyl-N-aralkylamino, lower N-alkyl-N- arylamino, lower aminoalkyl, lower N-alkylaminoalkyl, lower N,N-dialkylaminoalkyl, lower N-arylaminoalkyl, lower N-aralkylaminoalkyl, lower N-alkyl-N- aralkylaminoalkyl, lower N-alkyl-N-arylaminoalkyl, lower alkoxy aryloxy, lower aralkoxy, lower alkylthio, arylthio, lower aralkylthio, aminocarbonyl, lower aminocarbonylalkyl, lower N-alkylaminocarbonyl, N- arylaminocarbonyl, lower N,N-dialkylaminocarbonyl, lower N-alkyl-N-arylaminocarbonyl, lower cycloalkylaminocarbonyl, lower carboxyalkylaminocarbonyl, lower aralkoxycarbonylalkylaminocarbonyl, lower hydroxyalkyl, wherein R3 is selected from hydrido, lower alkyl, halo, cyano, lower hydroxyalkyl, lower alkoxy, lower alkylthio, lower N-alkylamino, lower N,N-dialkylamino, lower alkylsulfonyl and lower cycloalkyl; wherein R 4 is selected from lower aralkenyl, aryl, lower cycloalkyl, lower cycloalkenyl and five to ten membered heterocyclic; wherein R 4 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, lower alkenyl, lower alkylsulfonyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, sulfamyl, lower alkylaminocarbonyl, amino, lower N-alkylamino, lower N,N-dialkylamino, five or six membered heterocyclic, lower cycloalkylalkyl, nitro, R 7 N^ TH 3 and O wherein R 5 is lower alkyl; and wherein R 7 is selected from hydrido, lower alkyl, aryl and lower aralkyl; or a pharmaceutically-acceptable salt thereof. 6. The method of Claim 5 wherein R 1 is phenyl, substituted at a substitutable position with one or more radicals selected from fluoro, chloro, methyl, sulfamyl and 0.0 H , CH 3 —S-N=C-N ; CH 3 wherein R 2 is selected from hydrido, methyl, ethyl, isopropyl, tert-butyl, isobutyl, hexyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, cyano, carboxyl, methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl, tert-butoxycarbonyl, propoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, pentoxycarbonyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, pivaloyl, hexanoyl, trifluoroacetyl, cyanomethyl, ethoxycarbonylcyanoethenyl, 1, 1-difluoro-1- phenyImethyl, 1, 1-difluoro-1-phenylethyl, difluoroacetyl, methoxycarbonyldifluoromethyl, difluoroacetamidyl, N,N-dimethyldifluoroacetamidyl, N- phenyldifluoroacetamidyl, N-ethylamino, N-methylamino, N,N-dimethylamino, N,N-diethylamino, N-phenylamino, N- benzylamino, N-phenylethylamino, N-methyl-N- benzylamino, N-ethyl-N-phenylamino, N-methyl-N- phenylamino, aminomethyl, N-methylaminomethyl, N,N- dimethylaminomethyl, N-phenylaminomethyl, N- benzylaminomethyl, N-methyl-N-benzylaminomethyl, N- methyl-N-phenylaminomethyl, methoxy, ethoxy, phenoxy, benzyloxy, methylthio, phenylthio, benzylthio, N- methylurea, N-methylthiourea, N-methylacetamidyl, urea, ureamethyl, thiourea, thioureamethyl, acetamidyl, N- phenylthioureamethyl, N-benzylthioureamethyl, N- methylthioureamethyl, N-phenylureamethyl, N- benzylureamethyl, N-methylureamethyl, N- phenylacetamidylmethyl, N-benzylacetamidyImethyl, N- methylacetamidyImethyl, aminocarbonyl, aminocarbonyImethyl, N-methylaminocarbonyl, N- ethylaminocarbonyl, N-isopropylaminocarbonyl, N- propylaminocarbonyl, N-butylaminocarbonyl, N- isobutylaminocarbonyl, N-tert-butylaminocarbonyl, N- pentyla inocarbonyl, N-phenylaminocarbonyl, N,N- dimethylaminocarbonyl, N-methyl-N-ethylaminocarbonyl, N- (3-fluorophenyllaminocarbonyl, N- (4- methylphenyl)aminocarbonyl, N- (3- chlorophenyl)aminocarbonyl, N-methy1-N- (3- chlorophenyl)aminocarbonyl, N-(4- methoxyphenyl)aminocarbonyl, N-methy1-N- phenylaminocarbonyl, cyclopentylaminocarbonyl, cyclohexylaminocarbonyl, carboxymethylaminocarbonyl, benzyloxycarbonylmethylaminocarbonyl, hydroxypropyl, hydroxymethyl, and hydroxypropyl; wherein R-* is selected from hydrido, methyl, ethyl, isopropyl, tert- butyl, isobutyl, hexyl, fluoro, chloro, bromo, cyano, methoxy, methylthio, methylsulfonyl, N-methylamino, N- ethylamino, N,N-dimethylamino, N,N-diethylamino, cyclopropyl, cyclopentyl, hydroxypropyl, hydroxymethyl, and hydroxyethyl; and wherein R 4 is selected from phenylethenyl, phenyl, naphthyl, biphenyl, cyclohexyl, cyclopentyl, cycloheptyl, 1-cyclohexenyl, 2- cyclohexenyl, 3-cyclohexenyl, 4-cyclohexenyl, 1- cyclopentenyl, 4-cyclopentenyl, benzofuryl, 2,3- dihydrobenzofuryl, 1,2,3,4-tetrahydronaphthyl, benzothienyl, indenyl, indanyl, indolyl, dihydroindolyl, chromanyl, benzopyran, thiochromanyl, benzothiopyran, benzodioxolyl, benzodioxanyl, pyridyl, thienyl, thiazolyl, oxazolyl, furyl and pyrazinyl; wherein R 4 is optionally substituted at a substitutable position with one or more radicals selected from fluoro, chloro, bromo, methylthio, methy1sulfinyl, methyl, ethyl, propyl, isopropyl, tert-butyl, isobutyl, hexyl, ethylenyl, propenyl, methylsulfonyl, cyano, carboxyl, methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl, tert-butoxycarbonyl, propoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, pentoxycarbonyl, aminocarbonyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, bromodifluoromethyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, hydroxyl, methoxy, methylenedioxy, ethoxy, propoxy, n-butoxy, sulfamyl, methylaminosulfonyl, hydroxypropyl, hydroxyisopropyl, hydroxymethyl, hydroxyethyl, trifluoromethoxy, amino, N-methylamino, N-ethylamino, N-ethyl-N-methylamino, N,N-dime hylamino, N,N-diethylamino, formylamino, methylcarbonylamino, trifluoroacetamino, piperadinyl, piperazinyl, morpholino, cyclohexyImethyl, cyclopropylmethyl, eyelopentyImethyl, nitro, f 7 R 7 N NHa ' ^^ m2 . nd ^ ∞÷ ; 0 s o and wherein R 7 is selected from hydrido, methyl, ethyl, phenyl and benzyl; or a pharmaceutically-acceptable salt thereof. 7. The method of Claim 6 selected from compounds, and their pharmaceutically acceptable salts, of the group consisting of ethyl 1-[4- (aminosulfonyl)phenyl] -5-(4-chlorophenyl) -1H- pyrazole-3-carboxylate; ethyl 1-[4- (aminosulfonyl)phenyl] -5- (4-methylphenyl) -1H- pyrazole-3-carboxylate; isopropyl 1-[4- (aminosulfonyl) henyl] -5-(4- chlorophenyl) -lH-pyrazole-3-carboxylate; N- [4-methylphenyl] -1- [4- (aminosulfonyl)phenyl] -5- (4- fluorophenyl) -lH-pyrazole-3-carboxamide; N- [3-chlorophenyl] -1- [4- (aminosulfonyl)phenyl] -5- (4- fluorophenyl) -lH-pyrazole-3-carboxamide; N- [3-fluorophenyl] -1- [4- (aminosulfonyl)phenyl] -5- (4- fluorophenyl) -lH-pyrazole-3-carboxamide; N- [3-fluorophenyl] -l-[4- (aminosulfonyl) henyl] -5- (4- chlorophenyl) -lH-pyrazole-3-carboxamide, ■ phenylmethyl N- [ [1- [ - (aminosulfonyl)phenyl] -5- (4- chlorophenyl) -lH-pyrazol-3-yl]carbonyl]glycinate; 4-[5- (4-bromopheny1) -3-cyano-lH-pyrazol-l- y1]benzenesulfonamide; 4- [3-cyano-5- (4-fluorophenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (4-chlorophenyl) -3-cyano-lH-pyrazol-l- yl]benzenesulfonamide; 4- [3-cyano-5- (4-methoxyphenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[3-cyano-5- (4-methylphenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [3-cyano-5- (4-methylthiophenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (5-chloro-4-methoxyphenyl) -3-cyano-lH-pyrazol-l- yl]benzenesulfonamide; 4-[5- (5-bromo-4-methoxyphenyl) -3-cyano-lH-pyrazol-l- yl]benzenesulfonamide; 4- [3-cyano-5-phenyl-IH-pyrazol-1-y1]benzenesulfonamide; 4- [4-chloro-5- (4-fluorophenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [4-chloro-5- (4-chlorophenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [4-bromo-5- (4-chlorophenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [4-chloro-5-phenyl-lH-pyrazol-1-yl]benzenesulfonamide; 4-[4-chloro-5- (3,5-dichloro-4-methoxyphenyl) -lH-pyrazol- 1-yl]benzenesulfonamide; 4-[4-bromo-5- (4-methylphenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-chloro-5- (4-methylphenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-chloro-5- (3-chloro-4-methoxyphenyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-chloro-5- (4-methoxyphenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-bromo-5-(4-methoxyphenyl) -lH-pyrazol-1- y1]benzenesulfonamide; 4-[4-cyano-5- (4-methoxyphenyl) -lH-pyrazol-1- y1]benzenesulfonamide; 4-[4-chloro-5- (4-chlorophenyl) -3-(trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[4-ethyl-5-phenyl-3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-methy1-5-phenyl-3-(trifluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-methoxyphenyl) -4-methyl-3-(trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-chlorophenyl) -4-methyl-3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-chlorophenyl) -4-ethyl-3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[4-ethyl-5- (4-methylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[4-ethyl-5- (4-methoxy-3-methylphenyl) -3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4-[4-ethyl-5- (4-methoxyphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[4-ethyl-5- (3-fluoro-4-chlorophenyl) -3- (trifluoromethyl)-lH-pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-fluorophenyl)-4-methyl-3-(trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[4-methyl-5- (4-methylphenyl)-3-(trifluoromethyl) -1H- pyrazol-1-y1]benzenesulfonamide; 4-[4-fluoro-5-phenyl-3- (trifluoromethyl)-lH-pyrazol-1- y1]benzenesulfonamide; 4-[4-bromo-5- (4-chlorophenyl)-3- (difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[4-chloro-5- (3,5-dichloro-4-methoxyphenyl) -3- (difluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4-[4-chloro-3- (difluoromethyl)-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[4-bromo-3-(difluoromethyl)-5-phenyl-lH-pyrazol-l- y1]benzenesulfonamide; 4-[4-chloro-3- (difluoromethyl)-5-( -methoxyphenyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[4-chloro-3-cyano-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[4-chloro-5-(4-chlorophenyl) -3-cyano-lH-pyrazol-l- yl]benzenesulfonamide; 4-[4-chloro-3-cyano-5-(4-fluorophenyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-bromo-3-cyano-5-(4-fluorophenyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-bromo-3-cyano-5-phenyl-IH-pyrazol-1- yl]benzenesulfonamide; ethyl [1-(4-aminosulfonylphenyl) -4-bromo-5-(4- chlorophenyl)-lH-pyrazol-3-yl]carboxylate; methyl [1- (4-aminosulfonylphenyl)-4-chloro-5-phenyl-lH- pyrazol-3-y1]carboxylate; methyl [1- (4-aminosulfonylphenyl)-4-chloro-5- (4- chlorophenyl) -lH-pyrazol-3-yl]carboxylate; ethyl [1- (4-aminosulfonylphenyl)-4-chloro-5- (4- chlorophenyl)-lH-pyrazol-3-yl]carboxylate; methyl [1- (4-aminosulfonylphenyl)-4-chloro-5-(4- fluorophenyl) -lH-pyrazol-3-yl]carboxylate; methyl [1- (4-aminosulfonylphenyl)-4-bromo-5-(4- fluorophenyl)-lH-pyrazol-3-yl]carboxylate; methyl [1- (4-aminosulfonylphenyl)-4-chloro-5- (3-chloro- 4-methoxyphenyl) -lH-pyrazol-3-yl]carboxylate; methyl [1- (4-aminosulfonylphenyl)-4-chloro-5- (3,5- dichloro-4-methoxyphenyl) -lH-pyrazol-3- yl]carboxylate; methyl [1- (4-aminosulfonylphenyl)-5-(3-bromo-4- ethoxyphenyl) -4-chloro--lH-pyrazol-3-yl]carboxylate; 4- [4-chloro-3-isopropyl-5-phenyl-lH-pyrazol-l- y1]benzenesulfonamide; 4-[4-chloro-3-methyl-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[4-chloro-3-hydroxymethyl-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[4-chloro-5-(4-chlorophenyl) -3-hydroxymethyl-lH- pyrazol-1-yl]benzenesulfonamide; 4-[5-(4-chlorophenyl)-3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-phenyl-3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-fluorophenyl)-3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-cyanophenyl)-3-(trifluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (2,4-difluorophenyl)-3- (trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-methoxyphenyl)-3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (3,4-dichlorophenyl)-3- (trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-bromophenyl)-3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (2,4-dichlorophenyl)-3- (trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (3-chlorophenyl) -3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(4-methylphenyl)-3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (2-chlorophenyl)-3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(2-fluorophenyl)-3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-aminophenyl)-3- (trifluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(2-methylphenyl)-3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(4-fluoro-2-methylphenyl) -3-(trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5-(3-methylphenyl)-3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(4-ethoxyphenyl)-3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (3,5-dimethylphenyl-4-methoxy)-3-(trifluoromethyl)- IH-pyrazol-l-yl]benzenesulfonamide; 4- [5- (3-fluorophenyl) -3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(3-fluoro-4-methoxyphenyl)-3-(trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-methylthiophenyl) -3- (trifluoromethyl)-1H- pyrazol-1-y1]benzenesulfonamide; 4-[5-(4-chloro-3-methylphenyl)-3-(trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5-(4-ethylphenyl)-3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (2,4-dimethylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-y1]benzenesulfonamide; 4-[5- (2-methoxyphenyl) -3- (trifluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-methoxy-3-methylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-y1]benzenesulfonamide; 4-[5-(3-bromo-4-methylthiopheny1) -3-(trifluorome hyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (3-chloro-4-methylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-y1]benzenesulfonamide; 4- [5- (3, 4-dimethoxyphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (3-chloro-4-methoxyphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (3-chloro-4-methoxy-5-methylphenyl) -3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (3-ethyl-4-methoxyphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-fluoro-2-methoxyphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-methoxy-3- (3-propenyl)phenyl) -3- (trifluoromethyl) -lH-pyrazol-1-y1]benzenesulfonamide; 4- [5- (3, 5-dichloro-4-methoxyphenyl) -3- (trifluoromethyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4- [5- (3-chloro-4-fluorophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (3-fluoro-4-methylthiophenyl) -3- (trifluoromethyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4- [5- (5-methyl-4-methylthiophenyl) -3- (trifluoromethyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4- [5- (3-chloro-4-methylthiophenyl) -3- (trifluoromethyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4- [5- (4- (N,N-dimethylamino)phenyl) -3- (trifluoromethyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4- [5- (4-methyl-3-nitrophenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (4- (N-methylamino)phenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (3-amino-4-methylphenyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-chlorophenyl) -3- (difluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (4-methy1thiopheny1) -3- (difluoromethyl) -lH-pyrazol- 1-yl]benzenesulfonamide; 4-[5-(4-methylphenyl)-3-(difluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-phenyl-3-(difluoromethyl)-lH-pyrazol-1- y1]benzenesulfonamide; 4-[5-(4-methoxyphenyl)-3-(difluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5-(3-fluoro-4-methoxyphenyl)-3- (difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5-(4-chlorophenyl) -3-(difluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(2-fluoro-4-methoxyphenyl)-3-(difluoromethyl) -1H- pyrazol-1-y1]benzenesulfonamide; 4-[5- (3-chloro-4-methylphenyl) -3- (difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5-(3-chloro-4-methoxyphenyl)-3- (difluoromethyl) -1H- pyrazol-1-y1]benzenesulfonamide; 4-[5-(4-chloro-3-methylphenyl) -3- (difluoromethyl)-1H- pyrazol-1-y1]benzenesulfonamide; 4-[5-(3,4-dimethoxyphenyl)-3- (difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (3,5-dichloro-4-methoxyphenyl) -3- (difluoromethyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4-[5-(3,5-difluoro-4-methoxyphenyl) -3-(difluoromethyl)- IH-pyrazol-l-yl]benzenesulfonamide; 4-[5- (2-methoxyphenyl) -3- (difluoromethyl) -lH-pyrazol-1- y1]benzenesulfonamide; 4-[5-(3-bromo-4-methoxyphenyl) -3- (difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5- (4-methylsulfonylphenyl) -3- (difluoromethyl) -1H- pyrazo1-1-y1]benzenesulfonamide; 4-[5- (4-chlorophenyl)-3-(heptafluoropropyl) -lH-pyrazol- 1-yl]benzenesulfonamide; 4-[5-(4-chlorophenyl)-3- (chloro-difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4-[5-(4-chlorophenyl)-3-(pentafluoroethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -3- (3-hydroxypropyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4- [5- (4-chlorophenyl) -3- (cyanomethyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4- [5- (3,5-dichloro-4-methoxyphenyl) -3- (3-hydroxypropyl) - IH-pyrazol-l-yl]benzenesulfonamide; 4-[5- (3-chloro-4-methoxyphenyl) -3- (chloromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [3- (chloro-difluoromethyl) -5- (3-fluoro-4- methoxyphenyl) -IH-pyrazol-l-yl]benzenesulfonamide; ethyl 3- [1- (4-aminosulfonylphenyl) -5- (phenyl) -1H- pyrazol-3-yl] -2-cyano-2-propenoate; 4- [5- (phenyl) -3- (fluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (5-bromo-2-thienyl)-3- (difluoromethyl) -IH-pyrazol- l-yl]benzenesulfonamide; 4-[5- (5-chloro-2-thienyl) -3- (difluoromethyl) -lH-pyrazol- 1-yl]benzenesulfonamide; 4- [5- (1-cyclohexenyl) -3- (difluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (1-cyclohexyl) -3- (difluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (6-benzodioxanyl) -3- (difluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [3- (difluoromethyl) -5- (4-methylcyclohexyl) -IH-pyrazol- l-yl]benzenesulfonamide; 4- [5- (2-benzofuranyl) -3- (difluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (l,3-benzodioxol-5-yl) -3- (difluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2-benzofuryl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (5-bromo-2-thienyl) -3- (trifluoromethyl) -lH-pyrazol- 1-yl]benzenesulfonamide; 4- [5- (5-chloro-2-thienyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (5-indanyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (5-methyl-2-thienyl) -3- (trifluoromethyl) -1H- pyrazol-1-yl]benzenesulfonamide; 4- [5- (2,3-dihydrobenzofuran-2-yl) -3- (trifluoromethyl) - lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (1-cyclohexenyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(l,2,3, 4-tetrahydronaphth-5-yl) -3- (trifluoromethyl) -IH-pyrazol-l-yl]benzenesulfonamide; 4- [5- (2-benzothienyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5- (3,4-dihydro-2H-l-benzothiopyran-7-yl) -3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide; 4- [5- (4-methyl-l, 3-benzodioxol-6-yl) -3- (trifluoromethyl) -IH-pyrazol-l-yl]benzenesulfonamide; and 4-[5- (4-methyl-l,3-benzodioxol-5-yl) -3- (trifluoromethyl) -lH-pyrazol-1-yl]benzenesulfonamide. 8. The method of Claim 4 wherein R^ is phenyl substituted at a substitutable position with sulfamyl; wherein R 2 is selected from lower haloalkyl, cyano, carboxyl, lower alkoxycarbonyl, lower carboxyalkyl, aminocarbonyl, lower N-alkylaminocarbonyl, N- arylaminocarbonyl, lower N,N-dialkylaminocarbonyl, lower N-alkyl-N-arylaminocarbonyl, lower cycloalkylaminocarbonyl and lower hydroxyalkyl; wherein R^ and R 4 together form wherein m is 2; wherein A is selected from phenyl and five membered heteroaryl; and wherein R^ is one or more radicals selected from halo, lower alkyl, lower alkylsulfonyl, lower haloalkyl, lower alkoxy, amino and nitro; or a pharmaceutically-acceptable salt thereof. 9. The method of Claim 8 wherein R 2 is selected from fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, cyano, carboxyl, methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl, tert- butoxycarbonyl, propoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, pentoxycarbonyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, pivaloyl, hexanoyl, trifluoroacetyl, aminocarbonyl, N- methyla inocarbonyl, N-ethylaminocarbonyl, N- isopropylaminocarbonyl, N-propylaminocarbonyl, N- butylaminocarbonyl, N-isobutylaminocarbonyl, N- ert- butylaminocarbonyl, N-pentylaminocarbonyl, N- phenylaminocarbonyl, N,N-dimethylaminocarbonyl, N- methyl-N-ethylaminocarbonyl, N- (3- fluorophenyl)aminocarbonyl, N-(4- methylpheny1)aminocarbonyl, N- (3- chlorophenyl)aminocarbonyl, N- (4- methoxyphenyl)aminocarbonyl, N-me hy1-N- phenylaminocarbonyl, cyclohexylaminocarbonyl, hydroxypropyl, hydroxymethyl and hydroxyethyl; wherein A is selected from phenyl, furyl and thienyl; and wherein R^ is one or more radicals selected from fluoro, chloro, bromo, methylsulfonyl, methyl, ethyl, isopropyl, tert-butyl, isobutyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, methoxy, methylenedioxy, ethoxy, propoxy, n-butoxy, amino, and nitro; or a pharmaceutically-acceptable salt thereof. 10. The method of Claim 9 selected from compounds, and their pharmaceutically acceptable salts, of the group consisting of 4-[3-(difluoromethyl)-4,5-dihydro-7-methoxy-lH- benz[g]indazol-1-yl]benzenesulfonamide; 4-[3-(difluoromethyl)-4,5-dihydro-7-methyl-lH- benz[g]indazol-1-yl]benzenesulfonamide; 4-[4,5-dihydro-7-methoxy-3- (trifluoromethyl)-IH- benz[g]indazol-1-yl]benzenesulfonamide; 4-[4,5-dihydro-3- (trifluoromethyl)-IH-benz[g]indazol- 1-y1]benzenesulfonamide; 4-[4,5-dihydro-7-methyl-3-(trifluoromethyl) -1H- benz[g]indazol-l-yl]benzenesulfonamide; methyl[1-(4-aminosulfonylphenyl)-4,5-dihydro-7- methoxy-lH-benz[g]indazol-3-yl]carboxylate; and 4-[4,5-dihydro-3-trifluoromethyl-lH- thieno[3,2,g]indazol-1-yl]benzenesulfonamide. 11. The method of Claim 4 wherein R^- is selected from phenyl, naphthyl, biphenyl, and five- or six- membered heteroaryl, wherein R--- is substituted at a substitutable position with one or more radicals selected from halo, lower alkyl, lower alkoxy, hydroxyl and lower haloalkyl; wherein R 2 is selected from lower haloalkyl; wherein 3 is hydrido; and wherein R 4 is aryl substituted at a substitutable position with sulfamyl; or a pharmaceutically-acceptable salt thereof. 12. The method of Claim 11 selected from compounds, and their pharmaceutically acceptable salts, of the group consisting of 4-[1- (4-fluorophenyl)-3- (trifluoromethyl) -iH-pyrazol- 5-yl]benzenesulfonamide; and 4-[1- (4-methoxyphenyl) -3- (trifluoromethyl)-lH-pyrazol- 5-yl]benzenesulfonamide. 13. A method of treating inflammation or an inflammation-associated disorder in an animal, said method comprising administering to the animal having or susceptible to such inflammation or inflammation- associated disorder, a therapeutically-effective amount of a compound of Formula II wherein R 2 is selected from hydrido, alkyl, haloalkyl, alkoxycarbonyl, cyano, cyanoalkyl, carboxyl, aminocarbonyl, alkylaminocarbonyl, cycloalkylaminocarbonyl, arylaminocarbonyl, carboxyalkylaminocarbonyl, carboxyalkyl, aralkoxycarbonylalkylaminocarbonyl, aminocarbonylalkyl, alkoxycarbonylcyanoalkenyl and hydroxyalkyl; wherein R^ is selected from hydrido, alkyl, cyano, hydroxyalkyl, cycloalkyl, alkylsulfonyl and halo; and wherein R 4 is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R 4 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfonyl, cyano, nitro, haloalkyl, alkyl, hydroxyl, alkenyl, hydroxyalkyl, carboxyl, cycloalkyl, alkylamino, dialkylamino, alkoxycarbonyl, aminocarbonyl, alkoxy, haloalkoxy, sulfamyl, heterocyclic and amino; or a pharmaceutically-acceptable salt thereof. 14. The method of Claim 13 wherein R 2 is selected from hydrido, lower alkyl, lower haloalkyl, lower alkoxycarbonyl, cyano, lower cyanoalkyl, carboxyl, aminocarbonyl, lower alkylaminocarbonyl, lower cycloalkylaminocarbonyl, arylaminocarbonyl, lower carboxyalkylaminocarbonyl, lower aralkoxycarbonylalkylaminocarbony1, lower aminocarbonylalkyl, lower carboxyalkyl, lower alkoxycarbonylcyanoalkenyl and lower hydroxyalkyl; wherein R3 is selected from hydrido, lower alkyl, cyano, lower hydroxyalkyl, lower cycloalkyl, lower alkylsulfonyl and halo; and wherein R 4 is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R 4 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfonyl, cyano, nitro, lower haloalkyl, lower alkyl, hydroxyl, lower alkenyl, lower hydroxyalkyl, carboxyl, lower cycloalkyl, lower alkylamino, lower dialkylamino, lower alkoxycarbonyl, aminocarbonyl, lower alkoxy, lower haloalkoxy, sulfamyl, five or six membered heterocyclic and amino; or a pharmaceutically- acceptable salt thereof. 15. The method of Claim 14 selected from compounds, and their pharmaceutically-acceptable salts, of the group consisting of 4-[5- (4-chlorophenyl) -3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-phenyl-3- (trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[5-(4-fluorophenyl)-3-(trifluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 1704 207 4-[5-(4-methoxyphenyl) -3- (trifluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-chlorophenyl) -3-(difluoromethyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4- [5-(4-methylphenyl)-3- (trifluoromethyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[4-chloro-5-(4-chlorophenyl) -3- (trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[3-(difluoromethyl)-5- (4-methylphenyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[3- (difluoromethyl)-5-phenyl-lH-pyrazol-l- yl]benzenesulfonamide; 4-[3- (difluoromethyl) -5-(4-me hoxyphenyl) -lH-pyrazol-1- yl]benzenesulfonamide; 4-[3-cyano-5- (4-fluorophenyl)-lH-pyrazol-1- yl]benzenesulfonamide; 4-[3- (difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[5-(3-fluoro-4-methoxyphenyl) -3- (trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide; 4-[4-chloro-5-phenyl-lH-pyrazol-1- yl]benzenesulfonamide; 4-[5- (4-chlorophenyl)-3-(hydroxymethyl)-lH-pyrazol-1- yl]benzenesulfonamide; and 4-[5- (4- (N,N-dimethylamino)phenyl) -3- (trifluoromethyl) - IH-pyrazol-l-yl]benzenesulfonamide. 16. The method of Claim 1 for use in treatment of inflammation. 17. The method of Claim 1 for use in treatment of an inflammation-associated disorder. 18. The method of Claim 17 wherein the inflammation- associated disorder is arthritis. 19. The method of Claim 17 wherein the inflammation- associated disorder is pain. 20. The method of Claim 1 wherein the animal is a companion animal. 21. The method of Claim 1 wherein the animal is a farm animal.

Inventors: ISAKSON PETER C, TALLEY JOHN J, ISAKSON, PETER, C., TALLEY, JOHN, J.
Applicants: ISAKSON PETER C, SEARLE & CO, TALLEY JOHN J, G.D. SEARLE & CO., ISAKSON, PETER, C., TALLEY, JOHN, J.
Application year: 1996
Main classification: A61K31
IPC codes: A61K31, A61P29, C07D231, C07D401, C07D405, C07D409, C07D495