Apparatus for evaluating cardiac function of living subject

Abstract: An apparatus (8, 108) for evaluating a blood-ejecting function of a heart of a living subject, including a pressure pulse wave sensor (46) which is adapted to be worn on a body portion (42) of the subject to detect a pressure pulse wave (SM 2 ) which is produced from an artery (56) of the subject in synchronism with a heartbeat of the subject, first determining means (70) for determining a first value of an index corresponding to a systolic area which is defined by a waveform of a first heartbeat-synchronous pulse of the pressure pulse wave detected by the pressure pulse wave sensor before the subject undergoes a physical exercise, second determining means (72) for determining a second value of the index corresponding to a systolic area which is defined by a waveform of a second heartbeat-synchronous pulse of the pressure pulse wave detected by the pressure pulse wave sensor after the subject undergoes the physical exercise, and evaluating means (74) for evaluating the blood-ejecting function of the heart of the subject, based on the determined first and second values of the index.

Description: BACKGROUND OF THE INVENTION Field of the Invention The present invention relates to an apparatus for evaluating a cardiac function of a living subject such as a human being, in accordance with claims 1-12. Related Art Statement The blood-ejecting function of the heart of a living subject becomes more active when the subject undergoes an exercise test, and recovers back to its resting condition after the test. The volume of cardiac blood ejection is defined as the product of stroke volume (i.e., amount of blood ejected per stroke), SV, and heart rate, HR. Thus, it may be judged whether the cardiac blood-ejecting function of the subject is normal or not, by observing how the heart rate HR of the subject recovers back to its resting condition or value after the exercise test. Silent myocardial ischemia is one of heart diseases. Since this disease is "silent" to the patient, i.e., is not perceived by the patient, an accurate diagnosis should be made. However, this disease is characterized by lowered stroke volume SV, and accordingly the heart rate HR may not be relied upon in judging whether the cardiac blood-ejecting function of the patient is normal or not. EP 420 085 A3 discloses a heart function measuring device and corresponding method. This document describes blood pressure measuring from an upper arm artery of a subject and provides a waveform of a heartbeat synchronous pulse of the upper arm arterial blood pressure. SUMMARY OF THE INVENTION It is a first object of the present invention to provide an apparatus for providing accurate physical information relating to a cardiac blood-ejecting function of a living subject. It is a second object of the present invention to provide an apparatus for evaluating, with accuracy, a cardiac blood-ejecting function of a living subject. The above-indicated first object has been achieved according to a first aspect of the present invention, which provides an apparatus for providing physical information relating to a blood-ejecting function of a heart of a living subject, comprising a pressure pulse wave sensor which is adapted to be worn on a body portion of the subject to detect a pressure pulse wave produced from an artery of the subject in synchronism with a heartbeat of the subject, first determining means for determining a first value of an index corresponding to a systolic area which is defined by a waveform of a first heartbeat-synchronous pulse of the pressure pulse wave detected by the pressure pulse wave sensor before the subject undergoes a physical exercise, second determining means for determining a second value of the index corresponding to a systolic area which is defined by a waveform of a second heartbeat-synchronous pulse of the pressure pulse wave detected by the pressure pulse wave sensor after the subject undergoes the physical exercise, and a display device which displays, as the physical information, the determined first and second values of the index in comparison with each other, so that an observer evaluates the blood-ejecting function of the heart of the subject based on the determined first and second values of the index displayed by the display device. The systolic area which is defined by the waveform of each heartbeat-synchronous pulse of a pulse wave produced from an artery of a living subject corresponds to the stroke volume SV of the heart of the subject. The Applicants of the present application have found that an index relating to the systolic area takes different values before and after the subject undergoes a physical exercise and that the blood-ejecting function of the heart of the subject can be evaluated with accuracy by utilizing the difference of the index values, irrespective of whether the subject suffers from myocardial ischemia. Thus, the myocardial ischemia can be diagnosed with accuracy according to the principle of the present invention. In the physical-information providing apparatus in accordance with the first aspect of the invention, the display device displays the first index value determined with respect to the waveform of the pressure pulse wave detected before the physical exercise of the subject, and the second index value determined after the exercise, in comparison with each other. Therefore, an observer can easily evaluate the blood-ejecting function of the heart of the subject based on the first and second index values displayed by the display device, for example, the amount or rate of change of the second value from the first value or the time or rate of recovering of the second value back to a value substantially equal to the first value. Silent myocardial ischemia can be diagnosed by accurately evaluating the cardiac blood-ejecting function of the subject. According to a preferred feature of the first aspect of the invention, the apparatus further comprises evaluating means for evaluating the blood-ejecting function of the heart of the subject, based on the determined first and second values of the index, and the display device displays information indicative of a result of evaluation of the blood-ejecting function by the evaluating means. According to another feature of the first aspect of the invention, the apparatus further comprises a blood pressure measuring device which measures a blood pressure of the subject, the blood pressure measuring device including an inflatable cuff which is adapted to be worn on the subject, and calibrating means for determining a first relationship between blood pressure and magnitude of the pressure pulse wave, based on at least one magnitude of at least one heartbeat-synchronous pulse of the pressure pulse wave detected by the pressure pulse wave sensor before the subject undergoes the physical exercise, and at least one blood pressure value of the subject measured by the blood pressure measuring device before the subject undergoes the physical exercise, and determining a second relationship between blood pressure and magnitude of the pressure pulse wave, based on at least one magnitude of at least one heartbeat-synchronous pulse of the pressure pulse wave detected by the pressure pulse wave sensor after the subject undergoes the physical exercise, and at least one blood pressure value of the subject measured by the blood pressure measuring device after the subject undergoes the physical exercise, the calibrating means calibrating, according to the first relationship, the waveform of the first heartbeat-synchronous pulse and calibrating, according to the second relationship, the waveform of the second heartbeat-synchronous pulse, the first determining means determining the first value of the index corresponding to the systolic area defined by the calibrated waveform of the first heartbeat-synchronous pulse, the second determining means determining the second value of the index corresponding to the systolic area defined by the calibrated waveform of the second heartbeat-synchronous pulse. According to another feature of the first aspect of the invention, the apparatus further comprises a blood-pressure measuring device comprising an inflatable cuff which is adapted to be worn on the subject, a distal and a proximal microphone which are provided at a distal and a proximal position on the cuff worn on the subject, respectively, and which detect a plurality of distal arterial sounds at the distal position and a plurality of proximal arterial sounds at the proximal position, respectively, while a pressure in the cuff is changed, delay-time determining means for determining a delay time of a time of detection of each of the distal arterial sounds detected by the distal microphone, from a time of detection of a corresponding one of the proximal arterial sounds detected by the proximal microphone, curve providing means for determining a product of each of respective magnitudes of the distal arterial sounds and a corresponding one of the respective delay times of the distal arterial sounds, and providing a curve by connecting the respective determined products with one another along an axis indicative of the pressure of the cuff, and blood-pressure determining means for determining a blood pressure of the subject based on the curve provided by the curve providing means. The above-indicated second object has been achieved according to a second aspect of the present invention, which provides an apparatus for evaluating a blood-ejecting function of a heart of a living subject, comprising a pressure pulse wave sensor which is adapted to be worn on a body portion of the subject to detect a pressure pulse wave which is produced from an artery of the subject in synchronism with a heartbeat of the subject, first determining means for determining a first value of an index corresponding to a systolic area which is defined by a waveform of a first heartbeat-synchronous pulse of the pressure pulse wave detected by the pressure pulse wave sensor before the subject undergoes a physical exercise, second determining means for determining a second value of the index corresponding to a systolic area which is defined by a waveform of a second heartbeat-synchronous pulse of the pressure pulse wave detected by the pressure pulse wave sensor after the subject undergoes the physical exercise, and evaluating means for evaluating the blood-ejecting function of the heart of the subject, based on the determined first and second values of the index. In the blood-ejecting-function evaluating apparatus in accordance with the second aspect of the invention, the evaluating means evaluate the blood-ejecting function of the heart of the subject, based on the first index value determined with respect to the waveform of the pressure pulse wave detected before the exercise, and the second index value determined after the exercise. Therefore, the present apparatus can evaluate the blood-ejecting function with accuracy. In addition, silent myocardial ischemia can be diagnosed based on the accurate evaluation of the blood-ejecting function of the heart of the subject. According to a preferred feature of the second aspect of the invention, the evaluating means comprises first means for evaluating the blood-ejecting function of the heart of the subject, based on at least one of an amount of change of the determined second value from the determined first value and a rate of change of the determined second value from the determined first value. According to another feature of the second aspect of the invention, the first means of the evaluating means comprises judging means for judging whether the blood-ejecting function of the heart of the subject is normal, by comparing the one of the amount of change and the rate of change with a corresponding one of a first reference value and a second reference value. This judgment can be made with ease and accordingly no complex algorithm is needed to make this judgment. According to another feature of the second aspect of the invention, the second determining means comprises means for determining a plurality of the second values of the index each of which corresponds to a systolic area defined by a waveform of a corresponding one of a plurality of the second heartbeat-synchronous pulses of the pressure pulse wave detected by the pressure pulse wave sensor after the subject undergoes the physical exercise, and the evaluating means comprises second means for evaluating the blood-ejecting function of the heart of the subject, based on at least one of a time of recovering of the determined second values back to a value substantially equal to the determined first value and a rate of recovering of the determined second values back to a value substantially equal to the determined first value. In this case, the blood-ejecting function of the heart of the subject can be evaluated with higher accuracy. According to another feature of the second aspect of the invention, the second means of the evaluating means comprises judging means for judging whether the blood-ejecting function of the heart of the subject is normal, by comparing the one of the time of recovering and the rate of recovering with a corresponding one of a third reference value and a fourth reference value. According to another feature of the second aspect of the invention, the apparatus further comprises converting means for converting the waveform of each of the first and second heartbeat-synchronous pulses, to a converted waveform, according to a predetermined mathematical transfer function defining a relationship between a waveform of a heartbeat-synchronous pulse of a pulse wave detected in an aorta of the subject and a waveform of a corresponding heartbeat-synchronous pulse of a pulse wave detected from the artery of the body portion of the subject, the first determining means determining the first value of the index corresponding to the systolic area defined by the converted waveform of the first heartbeat-synchronous pulse, the second determining means determining the second value of the index corresponding to the systolic area defined by the converted waveform of the second heartbeat-synchronous pulse. In this case, the first and second index values are determined with higher accuracy based on the waveform of the intra-aortic pulse wave, and accordingly the blood-ejecting function can be evaluated with higher accuracy based on the first and second index values. According to another feature of the second aspect of the invention, the apparatus further comprises a blood pressure measuring device which measures a blood pressure of the subject, the blood pressure measuring device including an inflatable cuff which is adapted to be worn on the subject, and calibrating means for determining a first relationship between blood pressure and magnitude of the pressure pulse wave, based on at least one magnitude of at least one heartbeat-synchronous pulse of the pressure pulse wave detected by the pressure pulse wave sensor before the subject undergoes the physical exercise, and at least one blood pressure value of the subject measured by the blood pressure measuring device before the subject undergoes the physical exercise, and determining a second relationship between blood pressure and magnitude of the pressure pulse wave, based on at least one magnitude of at least one heartbeat-synchronous pulse of the pressure pulse wave detected by the pressure pulse wave sensor after the subject undergoes the physical exercise, and at least one blood pressure value of the subject measured by the blood pressure measuring device after the subject undergoes the physical exercise, the calibrating means calibrating, according to the first relationship, the waveform of the first heartbeat-synchronous pulse and calibrating, according to the second relationship, the waveform of the second heartbeat-synchronous pulse, wherein the first determining means determines the first value of the index corresponding to the systolic area defined by the calibrated waveform of the first heartbeat-synchronous pulse, and the second determining means determines the second value of the index corresponding to the systolic area defined by the calibrated waveform of the second heartbeat-synchronous pulse. In this case, the calibrated waveform of the first or second heartbeat-synchronous pulse detected before or after the physical exercise of the subject represents with high accuracy the blood pressure inside the wall of the artery. Thus, no possible error in determining the change of the second value from the first value is eliminated, and the blood-ejecting function can be evaluated with higher accuracy. According to another feature of the second aspect of the invention, the apparatus further comprises a blood-pressure measuring device comprising an inflatable cuff which is adapted to be worn on the subject, a distal and a proximal microphone which are provided at a distal and a proximal position on the cuff worn on the subject, respectively, and which detect a plurality of distal arterial sounds at the distal position and a plurality of proximal arterial sounds at the proximal position, respectively, while a pressure in the cuff is changed, delay-time determining means for determining a delay time of a time of detection of each of the distal arterial sounds detected by the distal microphone, from a time of detection of a corresponding one of the proximal arterial sounds detected by the proximal microphone, curve providing means for determining a product of each of respective magnitudes of the distal arterial sounds and a corresponding one of the respective delay times of the distal arterial sounds, and providing a curve by connecting the respective determined products with one another along an axis indicative of the pressure of the cuff, and blood-pressure determining means for determining a blood pressure of the subject based on the curve provided by the curve providing means. In the case where the blood pressure values of the subject are measured using the cuff before and after the physical exercise, it is particularly difficult to measure with accuracy the blood pressure value after the exercise, because the subject breaths hard immediately after the exercise and the blood pressure measurement using the cuff is adversely influenced by noise resulting from the physical motion of the subject due to the hard breathing. If the blood pressure values measured before and after the exercise are not accurate, the blood-ejecting function cannot be evaluated with accuracy. However, in the present embodiment, the curve significantly largely changes at two cuff-pressure values the higher one of which corresponds to a systolic blood pressure (BP) value of the subject and the lower one of which corresponds to a diastolic BP value of the subject. On the curve, those two cuff-pressure values are exaggerated or stressed because the magnitudes of the distal arterial sounds are multiplied by the corresponding delay times, respectively. Thus, the curve is free from adverse influences from noise resulting from, e.g., physical motion of the subject. Therefore, the BP measuring device can measure the BP values of the subject with higher accuracy than conventional BP measuring devices of Korotkoff-sound type or oscillometric type can. In the case where the BP values of the subject measured with high accuracy are used to calibrate the waveform of the pressure pulse wave detected before or after the exercise, the blood-ejecting function of the subject can be evaluated with higher accuracy. In addition, the accuracy of diagnosis of silent myocardial ischemia is improved. BRIEF DESCRIPTION OF THE DRAWINGS The above and optional objects, features, and advantages of the present invention will better be understood by reading the following detailed description of the preferred embodiments of the invention when considered in conjunction with the accompanying drawings, in which: Fig. 1 is a diagrammatic view of a blood-ejecting-function ("BEF") evaluating apparatus to which the present invention is applied; Fig. 2 is a diagrammatic view for explaining various functions of a control device of the BEF evaluating apparatus of Fig. 1; Fig. 3 is a graph showing a relationship determined by the control device of the apparatus of Fig. 1; Fig. 4 is a graph showing various index parameters each of which corresponds to a systolic area, SA, defined by the waveform of a heartbeat-synchronous pulse of a pressure pulse wave ("PPW") detected by a PPW sensor of the apparatus of Fig. 1; Fig. 5 is a graph showing an example of physical information which is displayed by a display device of the apparatus of Fig. 1, based on a first and a second index value determined by the apparatus of Fig. 1; Fig. 6 is a graph showing a time-wise change of the physical information of Fig. 5 that is also displayed by the display device of the apparatus of Fig. 1; Fig. 7 is a graph showing another example of physical information which is displayed by the display device of the apparatus of Fig. 1, based on the first and second index values determined by the apparatus of Fig. 1; Fig. 8 is a flow chart representing a control program according to which the apparatus of Fig. 1 operates; Fig. 9 is a time chart representing respective operations of an exercise device, a blood pressure ("BP") measuring device and the PPW sensor of the apparatus of Fig. 1, and respective variations of various sorts of physical information obtained from a living subject; Fig. 10 is a diagrammatic view corresponding to Fig. 1, showing another BEF evaluating apparatus as a second embodiment of the present invention; Fig. 11 is a diagrammatic view corresponding to Fig. 2, for explaining various functions of a control device of the BEF evaluating apparatus of Fig. 10; Fig. 12(A) is a graph showing respective magnitudes, MA, of distal arterial sounds (i.e., Korotkoff sounds or K sounds) detected by a distal-side microphone of the apparatus of Fig. 10; Fig. 12(B) is a graph showing respective delay times, DT, of the distal-side K sounds from corresponding proximal-side K sounds detected by a proximal-side microphone of the apparatus of Fig. 10; Fig. 12(C) is a graph showing a curve, L, provided by the control device of the apparatus of Fig. 10; Fig. 13 is a flow chart representing a BP measuring routine according to which the apparatus of Fig. 10 operates; DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Referring to Figs. 1 to 9, there will be described a blood-ejecting-function ("BEF") evaluating apparatus 8 to which the present invention is applied. In Fig. 1, the BEF evaluating apparatus 8 includes an inflatable cuff 10 including a rubber bag and a band-like cloth bag in which the rubber bag is accommodated. The cuff 10 is wound around, e.g., an upper arm 12 of a patient as a living subject. The cuff 10 is connected via piping 20 to a pressure sensor 14, a selector valve 16, and a first air pump 18. The selector valve 16 is selectively placed, under control of an electronic control device 28, in a first state in which the valve 16 permits pressurized air to be supplied from the air pump 18 to the cuff 10 to increase quickly the air pressure of the cuff 10 (hereinafter, referred to as the "cuff pressure"), a second state in which the valve 16 causes the cuff 10 to be deflated slowly, and a third state in which the valve 16 causes the cuff 10 to be deflated quickly. The pressure sensor 14 detects the cuff pressure (i.e., air pressure of the cuff 10), and generates a pressure signal, SP, representing the detected cuff pressure. The pressure signal SP is supplied to each of a static-pressure filter circuit 22 and a cuff-pulse-wave ("CPW") filter circuit 24. The static-pressure filter circuit 22 includes a low-pass filter which extracts, from the pressure signal SP, a cuff-pressure signal, SK, representative of a static or direct-current component, P k , of the pressure signal SP. The cuff-pressure signal SK is supplied via a first analog-to-digital (A/D) converter 26 to the control device 28. The CPW filter circuit 24 includes a band-pass filter which extracts, from the pressure signal SP, a cuff-pulse-wave ("CPW") signal, SM 1 , representative of an oscillating or alternating-current component of the pressure signal SP. The CPW signal SM 1 is supplied via a second A/D converter 30 to the control device 28. The alternating-current component represented by the CPW signal SM 1 corresponds to an oscillatory pressure wave, i.e., pulse wave which is produced from a brachial artery (not shown) of the patient in synchronism with the heartbeat of the patient and is propagated via skin tissue to the cuff 10. This pulse wave is referred to as the "cuff pulse wave" ("CPW") to be distinguished from a "pressure pulse wave" ("PPW") which will be described later. In the present embodiment, the cuff 10, the pressure sensor 14, and the CPW filter circuit 24 cooperate with one another to provide a first pulse wave sensor. The control device 28 is provided by a microcomputer including a central processing unit (CPU) 29, a read only memory (ROM) 31, a random access memory (RAM) 33, and an input and output (I/O) port (not shown). The CPU 29 processes input signals, including the signals SK, SM 1 , by utilizing the temporary-storage function of the RAM 33, according to control programs pre-stored in the ROM 31. In addition, the CPU 29 supplies drive signals via the I/O port to drive circuits (not shown) associated with the selector valve 16 and the air pump 18, respectively. Thus, the CPU 29 controls respective operations of the valve 16 and the pump 18. For example, when an oscillometric BP measurement using the cuff 10 is carried out at Step SA2 (Fig. 8), the CPU 29 controls the valve 16 and the pump 18 to increase quickly the cuff pressure P k up to a predetermined target value and subsequently decrease the cuff pressure at a low rate of 264 to 400 Pa/s (2 to 3 mmHg/sec). Based on the variation of the CPW represented by the CPW signal SM 1 provided by the CPW filter circuit 24 during the low-rate decreasing of the cuff pressure P k , the CPU 29 determines a systolic, a mean, and a diastolic BP value of the patient, according to a known oscillometric BP measuring method. In addition, the CPU 29 controls a display device 32 to display the thus determined BP values. A pressure-pulse-wave (PPW) detecting probe 34 includes a container-like sensor housing 36, and a fastening band 40 connected to the sensor housing 36. With the help of the fastening band 40, the PPW detecting probe 34 is detachably attached to a wrist 42 of the arm 12 of the patient on which the cuff 10 is worn, such that an opening of the sensor housing 36 is opposed to a body surface 38 of the patient. A PPW sensor 46 is secured via an elastic diaphragm 44 to inner surfaces of the sensor housing 36 such that the PPW sensor 46 is movable relative to the housing 36 and is advanceable through the opening of the housing 36 toward the body surface 38 of the patient. The sensor housing 36 and the diaphragm 44 cooperate with each other to define a pressure chamber 48, which is supplied with pressurized air from a second air pump 50 via a pressure regulator valve 52. Thus, the PPW sensor 46 is pressed on the body surface 38 with a pressing force, P HD , corresponding to the air pressure of the pressure chamber 48. In the present embodiment, the pressing forces of the PPW sensor 46 applied to the body surface 38 or the radial artery 56 are indicated in terms of pressure values (mmHg) of the pressure chamber 48. The sensor housing 36, the diaphragm 44, the pressure chamber 48, the second air pump 50, the pressure regulator valve 52, etc. cooperate with one another to provide a pressing device which presses the PPW sensor 46 against the radial artery 56 via the body surface or skin tissue 38. The PPW sensor 46 includes a semiconductor chip formed of a monocrystalline silicon which has a press surface 54, and a number of pressure-sensing semiconductor elements (not shown) which are arranged, in the press surface 54, in an array at a regular interval of distance (about 0.2 mm), such that the array of pressure-sensing elements extends in the direction of width of the radial artery 56. When the PPW sensor 46 is pressed against the radial artery 56 via the body surface 38 of the wrist 42, the PPW sensor 46 detects an oscillatory pressure wave, i.e., pressure pulse wave (PPW) which is produced from the radial artery 56 in synchronism with the heartbeat of the patient and is propagated via the body surface 38 to the PPW sensor 46. The PPW sensor 46 generates a PPW signal, SM 2 , representing the detected PPW, and supplies the PPW signal SM 2 to the control device 28 via a third A/D converter 58. An example of the pressure pulse wave (PPW) detected by the PPW sensor 46 is shown in an upper portion of the graph of Fig. 4, along a time axis. The PPW sensor 46 provides a second pulse wave sensor. The CPU 29 of the control device 28 processes the input signals, including the PPW signal SM 2 , by utilizing the temporary-storage function of the RAM 33, according to the control programs pre-stored in the ROM 31, and supplies drive signals to drive circuits (not shown) associated with the second air pump 50 and the pressure regulator valve 52, respectively. Thus, the CPU 29 controls respective operations of the pump 50 and the valve 52 to regulate the pressure of the pressure chamber 48 applied to the PPW sensor 46, i.e., the pressing force of the PPW sensor 46 applied to the radial artery 56 via the body surface or skin tissue 38. When a continuous PPW detecting operation is carried out at Step SA3 (Fig. 8), the CPU 29 determines an optimum pressing force, P HDP , of the PPW sensor 46 applied to the radial artery 56, based on the PPW detected by the PPW sensor 46 while the pressure of the pressure chamber 48 is slowly increased to flatten an upper portion of the wall of the artery 56 as shown in Fig. 1, and controls the pressure regulator valve 52 to maintain the pressure of the chamber 48 at the determined optimum pressing force P HDP . Fig. 2 illustrates various functions of the electronic control device 28 of the present BEF evaluating apparatus 8. The pressure sensor 14 and the static-pressure and CPW filter circuits 22, 24 cooperate with the control device 28 to provide BP measuring means 62 which measures, according to an oscillometric BP measuring method (JIS T 1115; JIS is Japanese Industrial Standard), a systolic BP value P BPSYS , a mean BP value P BPMEAN , and a diastolic BP value P BPDIA of a patient based on the variation of respective amplitudes of heartbeat-synchronous pulses of the CPW detected by the first pulse wave sensor while the pressure P k of the cuff 10 is slowly decreased or increased at the rate of 267 to 400 Pa/s (2 to 3 mmHg/sec). The CPW is represented by the CPW signal SM 1 provided by the CPW filter circuit 24. The PPW sensor 46 is worn on the wrist 42 of the same arm 12 of the patient as that on which the cuff 10 is worn, and detects the PPW produced from the radial artery 56 of the wrist 42. The control device 28 functions as waveform calibrating means 64 which determines a P BP -P M relationship between BP values P BP and PPW magnitudes P M that is expressed by a mathematical linear function and is shown in Fig. 3, based on at least two of a first combination of an upper-peak magnitude, P Hpk , of a heartbeat-synchronous pulse of the PPW detected by the PPW sensor 46 and a systolic BP value P BPSYS measured by the BP measuring means 62, a second combination of a mean magnitude of the same pulse and a measured mean BP value P BPMEAN , and a third combination of a lower-peak magnitude, P Lpk , of the same pulse and a measured diastolic BP value P BPDIA . The mean magnitude of each pulse of the PPW may be defined as a height of the center of gravity of an area defined by the waveform of that pulse. The waveform calibrating means 64 determines a P BP -P M relationship before or after the patient undergoes a physical exercise on an exercise device 68, and calibrates the waveform of the PPW detected by the PPW sensor 46 before or after the physical exercise of the patient, according to the P BP -P M relationship determined before or after the exercise. The calibrated waveform of the PPW represents, with high accuracy, the actual change of blood pressure inside the radial artery 56. Fig. 3 shows an example of a P BP -P M relationship between BP values P BP and PPW magnitudes P M that is determined by the CPU 29. This relationship is expressed by the following linear function (1): P BP = A•P M + B where A is a constant corresponding to the slope of the linear function (1) and B is a constant corresponding to the intercept of the axis of ordinate indicative of BP values P BP . The selector valve 16 and the first air pump 18 cooperate with the control device 28 to provide a cuff-pressure regulating device which regulates the air pressure P k of the cuff 10 (i.e., cuff pressure P k ) that is detected by the pressure sensor 14 when each oscillometric BP measurement using the cuff 10 is carried out. The cuff-pressure regulating device changes the cuff pressure P k according to a well-known procedure, so that the BP measuring means 62 measures BP values of the patient using the cuff 10. For example, the regulating device increases the cuff pressure P k up to a target value, e.g., 23.998 Pa (180 mmHg), which is sufficiently higher than an estimated systolic BP value of the patient and subsequently decreases the cuff pressure P k slowly at the rate of 267 to 400 Pa/s (2 to 3 mmHg/sec), during a measurement period in which BP values of the patient are determined by the BP measuring means 62 according to a well-known oscillometric BP determining algorithm. After the BP measuring operation, the regulating device quickly deflates the cuff 10. As shown in Fig. 2, between the PPW sensor 46 and the waveform calibrating means 64, there is provided waveform converting means 66 which converts the PPW detected by the PPW sensor 46, into a waveform which would be detected inside the aorta of the patient, according to a predetermined transfer function, TF, which describes or defines the change of PPW transmitted from the aorta to the position where the PPW sensor 46 is worn. The thus converted waveform clearly shows the rising point (i.e., minimum or lower-peak point), upper-peak point, dicrotic notch, DN, etc. of each heartbeat-synchronous pulse of the PPW. The notch DN occurs in relation with the closure of the aortic valves of patient's heart. The exercise device 68 is provided by a well-known treadmill. However, the exercise device 68 may otherwise be provided by a different device such as an ergometer. The intensity and duration of the physical exercise may be changed within respective safe ranges, on the exercise device 68, depending upon the age, fitness, and condition of the patient. First-index-value determining means 70 determines a first index value, EV 1 , corresponding to a systolic area, SA, which is defined by a systolic portion of the waveform of each heartbeat-synchronous pulse of the PPW detected by the PPW sensor 46, before the patient undergoes a physical exercise on the exercise device 68. The systolic area SA is indicated by inclined lines in the upper half of the graph of Fig. 4. Fig. 4 illustrates respective definitions of various index parameters of the waveform of each pulse of PPW. For example, a pressure value, P dn , corresponds to the notch DN; a pulse pressure, PP, is equal to the difference between the two pressure values P Hpk , P Lpk (PP = P Hpk - P Lpk ); a pre-ejection period, PEP, is equal to the time interval between a Q wave of a heartbeat-synchronous pulse of ECG (electrocardiogram) and a rising point of a corresponding pulse of PPW; a left ventricular ejection time, ET (=LVET), is equal to the time interval between the rising point and the notch DN; and a time interval, T pk , is equal to the interval between the rising point and the upper-peak point. The index parameter EV may be selected from a first parameter group including a ratio, P dn /P Hpk ; a ratio, P dn /P Lpk ; a ratio, P dn /PP; and a ratio, PP/P Lpk . Otherwise, the index parameter EV may be selected from a second parameter group including a ratio, PEP/ET; a ratio, Tpk/ET; and a maximum slope, (dP/dt) max , of a rising portion of the waveform of each pulse of PPW. The rising portion of each pulse corresponds to the time interval T pk . It is thought that the systolic area SA of PPW indicated by inclined lines in Fig. 4 is proportional to a stroke volume, SV, of the heart of the patient. Each of the various index parameters of the first parameter group indicates how high the pressure value P dn corresponding to the notch DN is relative to the pressure value P Lpk corresponding to the lower-peak point. Meanwhile, it is thought that the shorter the ejection time ET is, the lower the pressure value P Hpk corresponding to the upper-peak point is. Each of the various index parameters of the second parameter group indicates how long the ejection time ET is. Anyway, each of the index parameters of the first and second parameter groups corresponds to the systolic area SA defined by the waveform of PPW, and indirectly represents the actual stroke volume of the heart of the patient. Second-index-value determining means 72 determines a second index value, EV 2 , corresponding to a systolic area SA defined by the waveform of PPW detected by the PPW sensor 46 after the patient undergoes the physical exercise on the exercise device 68. The second index EV 2 is of the same sort as that of the first index EV 1 , that is, the single sort of index EV is selected from the above-indicated first or second parameter group. An actual value of the selected index parameter EV is determined before and after the physical exercise of the patient. Evaluating means 74 evaluates the blood-ejecting function of the patient based on a change of the second index value EV 2 from the first index value EV 1 . For example, the evaluating means 74 may evaluate the blood-ejecting function by judging whether an amount of change, Δ EV (= EV 2 - EV 1 ), or a rate of change, EV 2 /EV 1 , of the first and second index values EV 1 , EV 2 is greater than a first or second reference value, respectively. Otherwise, the evaluating means 74 may evaluate the blood-ejecting function based on a time of recovery, TR, of the second index values EV 2 back to a value substantially equal to the first index value EV 1 after the physical exercise, or a rate of recovery, * EV 2 , of the second index values EV 2 after the exercise. Display means 76 controls the display device 32 to display the second index value EV 2 in comparison with the first index value EV 1 , so that an observer can evaluate the blood-ejecting function of the patient. Figs. 5, 6, and 7 shows examples of physical information displayed by the display device 32. Fig. 5 is a circular graph showing the percentage (%) of the second index value EV 2 (indicated by inclined lines) relative to the first index value EV 1 (100 %). In Fig. 5, the second value EV 2 is compared with the first value EV 1 as 100 %. Fig. 6 shows a time-wise change of ratio, EV 2 /EV 1 , (%) of the second index values EV 2 to the first index value EV 1 during and after the physical exercise. In Fig. 6, the ratio EV 2 /EV 1 (%) is compared with 100 % where EV 2 = EV 1 . Fig. 7 is a graph having four axes including a first axis indicative of systolic blood pressure, P SYS ; a second axis indicative of an amplitude, ST, between S wave and T wave of each pulse of ECG; a third axis indicative of heart rate, HR; and a fourth axis indicative of index parameter EV. Respective plotted values on the four axes are connected with straight lines. In Fig. 7, solid lines connect the values obtained before the exercise, and broken lines connect the values obtained after the exercise. The second index value EV 2 is compared with the first index value EV 1 on the fourth axis. Each of Figs. 5 to 7 shows the case where the blood-ejecting function of the patient becomes low after the physical exercise. Hereinafter, there will be described the operation of the electronic control device 28 of the BEF evaluating apparatus 8 constructed as described above, by reference to the flow chart of Fig. 8. First, at Step SA1, the CPU 29 of the control device 28 judges whether a START switch (not shown) has been operated to start the BEF evaluating apparatus 8. While negative judgments are made at Step SA1, Step SA1 is repeated. Meanwhile, if a positive judgment is made at Step SA1, the control of the CPU 29 goes to Step SA2 to operate the BP measuring means 62 to carry out an oscillometric BP measurement using the cuff 10. This operation corresponds to a time period from point "A" to point "B" shown in Fig. 9. At Step SA2, first the cuff 10 is inflated up to a target pressure (e.g., 23.998 Pa (180 mmHg)) sufficiently higher than an estimated systolic BP value of the patient. Then, the first air pump 18 is stopped and the selector valve 16 is switched to the second state to decrease the cuff pressure slowly at the rate of about 267 to 400 Pa/s (2 to 3 mmHg/sec). Based on the variation of respective amplitudes of heartbeat-synchronous pulses of the CPW signal SM 1 obtained during this slow cuff-pressure decreasing, the CPU 29 determines, according to a well-known oscillometric BP determining algorithm, a systolic, a mean, and a diastolic BP value P BPSYS , P BPMEAN , P BPDIA of the patient. In addition, based on the time interval of successive two pulses of the CPW, the CPU 29 determines a heart rate HR of the patient. The thus measured BP values and heart rate are displayed on the display device 32. Subsequently, the selector valve 16 is switched to the third state to deflate the cuff 10 quickly. This corresponds to point "B" shown in Fig. 9. Step SA2 is followed by Step SA3 to determine a relationship between blood pressure and magnitude of PPW, based on the BP values P BPSYS , P BPDIA measured at Step SA2 and magnitudes (i.e., voltages) of the PPW signal SM 2 produced by the PPW sensor 46. More specifically, after Step SA2, the CPU 29 reads in a length of PPW signal SM 2 corresponding to one heartbeat-synchronous pulse of PPW, and determines an upper-peak and a lower-peak magnitude P Hpk , P Lpk of that pulse. Based on the first combination of upper-peak magnitude P Hpk and systolic BP value P BPSYS and the second combination of lower-peak magnitude P Lpk and diastolic BP value P BPDIA , the CPU 29 determines a linear function defining the relationship between blood pressure P BP and PPW magnitude P M as shown in Fig. 3. The PPW signal SM 2 produced by the PPW sensor 46 is calibrated according to this relationship by the CPU 29. The thus calibrated waveform of the PPW signal SM 2 represents, with high accuracy, the blood pressure inside the radial artery 56 of the patient. Step SA3 corresponds to the waveform calibrating means 64 shown in Fig. 2. Step SA3 is followed by Step SA4 to read in a predetermined number of heartbeat-synchronous pulses of PPW detected by the PPW sensor 46 before the patient undergoes the physical exercise. Step SA4 is followed by Step SA5 to convert the waveform of each pulse into the waveform which would be obtained inside the aorta of the patient. For example, a transfer function TF which defines or describes the transfer of PPW from the aorta to the position where the PPW sensor 46 is worn, is pre-determined and employed in the control program. The PPW signal SM 2 is divided by the transfer function TF, so that the waveform of PPW signal SM 2 is converted into the waveform of PPW which would be obtained in the aorta. The transfer function TF may experimentally be determined in advance by using a catheter inserted in the aorta of a human being and the PPW Sensor 46 worn on a body portion of the person. Step SA5 corresponds to the waveform converting means 66. Subsequently, at Step SA6, the CPU 29 determines an index value EV corresponding to a systolic area SA defined by the waveform of PPW detected by the PPW sensor 46 before the physical exercise is burdened on the patient on the exercise device 68. The thus determined index value EV is the first index value EV 1 , and Step SA6 corresponds to the first-index-value determining means 70. Step SA6 is followed by Step SA7 to judge whether the physical exercise has ended, based on an output signal produced from the exercise device 68. If a negative judgment is made at Step SA7, the CPU 29 outputs a permission signal to the exercise device 68 so that the device 68 can start its operation to burden physical exercise on the patient. In response to a starting operation of the device 68 by a medical staff such as a doctor or a nurse, the device 68 starts to give physical exercise at a predetermined intensity for a predetermined time period. This corresponds to point "C" shown in Fig. 9. While Steps SA7 and SA8 are repeated, a positive judgment is made at Step SA7, if the predetermined physical exercise ended on the exercise device 68. In this case, Step SA7 is followed by Step SA9 to judge whether a second index value EV 2 has been determined. While negative judgments are made at Step SA9, the control of the CPU 29 goes back to Step SA2 to carry out another BP measurement using the cuff 10. This corresponds to the time period from point "D" to point "E" shown in Fig. 9. Subsequently, Steps SA3 to SA5 are carried out to read in the PPW detected by the PPW sensor 46 after the physical exercise and convert the waveform of the thus read PPW into the waveform which would be obtained inside the aorta. Moreover, at Step SA6, the CPU 29 determines an index value EV corresponding to a systolic area SA defined by the waveform of PPW detected by the PPW sensor 46 after the physical exercise, in the same manner as that employed to determine the first index value EV 1 . The thus determined index value EV is the second index value EV 2 , and Step SA6 corresponds to the second-index-value determining means 72. Once the physical exercise ends and the second index value EV 2 is determined, a positive judgment is made at each of Steps SA7 and SA9. This corresponds to point "F" shown in Fig. 9. Then, the control of the CPU 29 goes to Step SA10 to evaluate the blood-ejecting function of the heart of the patient based on a change of the second index value EV 2 relative to the first index value EV 1 . For example, the CPU 29 may determine an index value EV with respect to each of a predetermined number of heartbeat-synchronous pulses of PPW detected by the PPW sensor 46 before the physical exercise, and may determine an average of those index values EV as the first index value EV 1 . Similarly, the CPU 29 may determine an index value EV with respect to each of a predetermined number of pulses of PPW detected after the physical exercise, and may determine an average of those index values EV as the second index value EV 2 . In this case, the CPU 29 judges that the blood-ejecting function of the patient is normal, if an amount of change Δ EV (= EV 2 - EV 1 ) or a rate of change EV 2 /EV 1 is greater than a predetermined first or second reference value, respectively, and judges that the blood-ejecting function is low, if the amount of change Δ EV or the rate of change EV 1 /EV 2 is not greater than the first or second reference value, respectively. Otherwise, the CPU 29 may be adapted to judge that the blood-ejecting function is normal, if the recovery time TR of the second index values EV 2 determined after the exercise, back to a value equal to the first index time EV 1 determined before the exercise is shorter than a predetermined reference value, or if the rate of recovery (i.e.., slope) Δ EV 2 of the second index values EV 2 determined after the exercise is greater than a predetermined reference value, and judge vice versa. If the blood-ejecting function of the patient is normal, the systolic area SA defined by the waveform of PPW increases in response to the starting of the physical exercise and quickly decreases or recovers back to the initial condition before the exercise, in response to the ending of the exercise. Step SA10 corresponds to the evaluating means 74 shown in Fig. 2. Step SA10 is followed by Step SA11 to control the display device 32 to display, on a screen thereof, the result of evaluation of the blood-ejecting function of the patient carried out at Step SA10, and the various graphical representations shown in Figs. 5 to 7. From those representations, the medical staff can easily grasp the change of the second index value or values EV 2 obtained after the exercise, from the first index value or values EV 1 obtained before the same. Step SA11 corresponds to the display means 76 shown in Fig. 2. As is apparent from the foregoing description, the first-index-value determining means 70 determines the first index value EV 1 corresponding to the systolic area SA defined by the waveform of each heartbeat-synchronous pulse of PPW detected by the PPW sensor 46 before the physical exercise of the patient, and the second-index-value determining means 72 determines the second index value EV 2 corresponding to the systolic area SA defined by the waveform of each pulse of PPW detected by the PPW sensor 46 after the exercise. The display device 32 displays the second index value EV 2 in comparison with the first index value EV 1 . Thus, the medical staff can easily evaluate the blood-ejecting function of the patient based on the change of the second value EV 2 from the first value EV 1 . Since the blood-ejecting function of the patient is evaluated with accuracy, silent myocardial ischemia can be diagnosed with accuracy on the patient by the doctor. In addition, the evaluating means 74 easily evaluates the blood-ejecting function of patient's heart, based on the change of the second value EV 2 from the first value EV 1 , e.g., the amount of change, the rate of change, and the time-wise change of the second index values EV 2 obtained after the exercise. Even if the medical staff is not skilled in evaluating the blood-ejecting function, the present apparatus 8 can evaluate it with accuracy. Because of the accurate evaluation of the blood-ejecting function, the doctor can make an accurate diagnosis of silent myocardial ischemia on the patient. In the case where the evaluating means 74 evaluates the blood-ejecting function of the patient by judging whether the amount or rate of change of the second index value EV 2 from the first index value EV 1 is greater than a predetermined first or second reference value, it does not need a complex algorithm to evaluate the cardiac function. Meanwhile, in the case where the evaluating means 74 evaluates the blood-ejecting function of the patient based on the time of recovery TR of the second index values EV 2 back to a value equal to the first index value EV 1 , or the rate of change of the second index values EV 2 , the blood-ejecting function can be evaluated with high accuracy. Since the waveform converting means 66 converts the waveform of PPW detected by the PPW sensor 46 into the waveform of PPW which would be detected inside the aorta of the patient, according to the transfer function TF, the first and second index values EV 1 , EV 2 are determined with high accuracy on the converted waveform of PPW. Thus, the accuracy of evaluation of the blood-ejecting function is improved. The waveform calibrating means 64 determines a relationship between blood pressure and PPW magnitude based on the BP values measured by the BP measuring means 62 including the cuff 10 and the magnitudes of PPW detected by the PPW sensor 46, before or after the patient undergoes the physical exercise, and calibrates the waveform of PPW detected by the PPW sensor before or after the exercise. Thus, the waveform of PPW detected before or after the exercise is calibrated so that the calibrated waveform represents with accuracy the blood pressure inside the artery of the patient. Therefore, any error in calculating the change of the second index value EV 2 from the first index value EV 1 is eliminated, and the blood-ejecting function of the patient is evaluated with high accuracy. In the first embodiment shown in Figs. 1-9, the waveform converting means 66 or Step SA5 is employed for converting the waveform of PPW detected from the radial artery 56, into the waveform which would be detected from the aorta. However, the converting means 66 or Step SA5 may be omitted. While in the first embodiment both the evaluating means 74 and the display means 76 are employed, it is possible to omit one of the two means 74, 76. Although in the first embodiment the PPW sensor 46 is worn on a wrist of the patient to detect a PPW from the radial artery 56, it is possible to wear the PPW sensor 46 on an ankle or the neck of the patient to detect a PPW from a dorsal pedal artery or a carotid artery of the patient. While in the first embodiment a single index parameter EV is selected from the first parameter group or the second parameter group, it is possible to employ a plurality of sorts of index parameters and evaluate the blood-ejecting function of the patient based on the determined first and second index values of each of the index parameters. In the case where the evaluating apparatus 8 employs the ratio PEP/ET as the index parameter EV, or uses the R-wave magnitude or ST level of ECG as auxiliary information that helps medical staff to find myocardial ischemia, the apparatus 8 is provided with an electrocardiograph which produces an electrocardiogram (ECG) representing the changes of electric potential of patient's heart. While in the first embodiment the waveform calibrating means 64 determines a P BP -P M relationship based on the systolic and diastolic BP values of the patient measured using the cuff 10 and the upper-peak and lower-peak magnitudes of one heartbeat-synchronous pulse of PPW detected by the PPW sensor 46, it is possible to determine a P BP -P M relationship based on the measured mean BP value and the detected mean magnitude of one pulse of PPW and at least one of the first combination of the measured systolic BP value and the detected upper-peak magnitude of one pulse of PPW and the second combination of the measured diastolic BP value and the detected lower-peak magnitude. Although in the first embodiment the oscillometric BP measuring method is employed to measure BP values of a patient at Step SA2, it is possible to employ a Korotkoffsound-type BP-measuring method in which a microphone is provided in association with the cuff 10 and, while the cuff pressure P k is changed, the control device 28 determines a systolic and a diastolic BP value of the patient by detecting, through the microphone, Korotkoff sounds produced from the brachial artery under the cuff 10. Referring next to Figs. 10 to 13, there will be described a second embodiment of the present invention. The second embodiment relates to a blood-ejecting-function ("BEF") evaluating apparatus 108 which has basically the same hardware construction as that of the BEF evaluating apparatus 8 as the first embodiment shown in Fig. 1. The following description only relates to the differences of the second embodiment from the first embodiment. The same reference numerals as used in the first embodiment are used to designate the corresponding elements or parts of the second embodiment, and the description of those elements or parts is omitted. An inflatable cuff 10 is provided with a proximal-side microphone 110a fixed to a proximal-side portion of the cuff 10, and a distal-side microphone 110b fixed to a distal-side portion of the cuff 10. The proximal-side microphone 110a detects proximal-side K (Korotkoff) sounds produced from a proximal-side portion of a brachial artery under the proximal-side portion of the cuff 10, and produces a first K-sound signal, SSa, representing the detected proximal-side K sounds, and the distal-side microphone 110b detects distal-side K sounds produced from a distal-side portion of the brachial artery under the distal-side portion of the cuff 10, and produces a second K-sound signal, SSb, representing the detected distal-side K sounds. The two electric signals SSa, SSb are supplied to an electronic control device 128 via a K-sound filter circuit 122 and an A/D converter 126. The K-sound filter circuit 122 includes a band-pass filter which permits only a signal component having frequencies corresponding to K sounds to pass therethrough. Fig. 11 illustrates various functions of the control device 128 of the second BEF evaluating apparatus 108. The control device 128 of the second apparatus 108 is different from the control device 28 of the first apparatus 8 in that the control device 128 functions as BP measuring means 160. The BP measuring means 160 increases an air pressure P k of the cuff 10 up to a target pressure value which is higher than an estimated systolic BP value of a living subject or a patient and subsequently decreases the cuff pressure P k slowly at the rate of 267 to 400 Pa/s (2 to 3 mmHg/sec). During this slow cuff-pressure decreasing, the proximal-side and distal-side microphones 110a, 110b detect the proximal-side and distal-side K sounds, respectively. The control device 128 determines a delay time, DT, of the time of detection of each of the distal-side K sounds from that of a corresponding proximal-side K sound, and a magnitude (i.e., amplitude), MA, of each distal-side K sound and, based on the delay times DT and the K-sound magnitudes MA, the control device 128 determines a curve, L, shown in Fig. 12(C). Moreover, based on the curve L, the control device 128 determines a systolic and a diastolic BP value P BPSYS , P BPDIA of the patient. As shown in Fig. 11, the BP measuring means 160 includes delay-time determining means 161, curve providing means 162, and BP-value determining means 163. The delay-time determining means 161 determines a delay time DT of the time of detection of each of the distal-side K sounds from that of a corresponding one of the proximal-side K sounds. The curve providing means 162 calculates the product of a magnitude MA of each of the distal-side K sounds and a corresponding one of the delay times DT, and provides a curve L connecting the thus calculated products along an axis indicative of cuff pressure P k . The BP-value determining means 163 specifies two cuff-pressure values, P KSYS , P KDIA , where the curve L significantly largely increases and decreases as the cuff pressure Pk decreases, and determines the thus specified pressure values P KSYS , P KDIA as a systolic and a diastolic BP value P BPSYS , P BPDIA of the patient. Figs. 12(A) and 12(B) show the respective magnitudes MA of the distal-side K sounds detected by the distal-side microphone 110b, and the respective delay times DT of the distal-side K sounds from the corresponding proximal-side K sounds, respectively. The second BEF evaluating apparatus 108 operates basically according to the same flow chart as that shown in Fig. 8. However, at Step SA2, the second apparatus 108 carries out a BP measuring routine in accordance with the flow chart of Fig. 13. A CPU 129 of the control device 128 determines a systolic and a diastolic BP value of the patient according to the control program represented by the flow chart of Fig. 13 and stored in a ROM 131, by utilizing the temporary-storage function of a RAM 133. First, at Step SA102-1, the CPU 129 starts a first air pump 18 and switches a selector valve 16 to a first state to increase the pressure P k of the cuff 10 quickly. Subsequently, at Step SA102-2, the CPU 129 judges whether the cuff pressure P k has been increased up to a target value P 1 (e.g., 23.998 Pa (180 mmHg)) which is pre-determined to be sufficiently higher than an estimated systolic BP value of the patient. If a negative judgment is made at Step SA102-2, Steps SA102-1 and SA102-2 are repeated to continue to increase the cuff pressure P k . Meanwhile, if a positive judgment is made, the control of the CPU 129 goes to Step S102-3 to stop the air pump 18 and switch the selector valve 16 to the second state to decrease the cuff pressure P k slowly at the rate of about 267 to 400 Pa/s (2 to 3 mmHg/sec). Subsequently, at Step SA102-4, the CPU 129 judges whether the CPU 29 has received a K sound from each of the microphones 110a, 110b. If a negative judgment is made at Step SA102-4, Steps SA102-3 and SA102-4 are repeated. On the other hand, if a positive judgment is made at Step SA102-4, the control of the CPU 129 goes to Steps SA102-5, SA102-6, and SA102-7, i.e., BP determining algorithm. More specifically described, at Step SA102-5, the CPU 129 determines a delay time DT of the time of detection of the distal-side K sound by the distal-side microphone 110b, from that of the corresponding proximal-side K sound by the proximal-side microphone lla. The CPU 129 determines this delay time DT by calculating the difference of the time of production of a heartbeat-synchronous pulse of the K-sound signal SSb from the time of production of a corresponding heartbeat-synchronous pulse of the K-sound signal SSa. Step SA102-5 corresponds to the delay-time determining means 161. At Step SA102-6, the CPU 129 calculates an evaluation value, L(P k ), as the product of the delay time DT determined at Step SA102-5 and a magnitude MA of the distal-side K sound detected by the distal-side microphone 110b at Step SA102-4, i.e., a magnitude of the heartbeat-synchronous pulse of the K-sound signal SSb. The CPU 129 calculates the evaluation value L(Pk) for each of the distal-side K sounds which are detected by the distal-side microphone 110b during the period of slow deflation of the cuff pressure P k . Thus, the CPU 129 provides an evaluation curve L connecting the calculated evaluation values L(P k ), along the axis of abscissa indicative of the cuff pressure P k . Step SA102-6 corresponds to the curve providing means 162. Step SA102-6 is followed by Step SA102-7 to specify two cuff-pressure values where the curve L significantly largely changes, determines one P KSYS of the two cuff-pressure values which is higher than the other, as a systolic BP value P BPSYS of the subject, and determines the other, lower one P KDIA of the two cuff-pressure values as a diastolic BP value P BPDIA of the subject. Step SA102-7 corresponds to the BP-value determining means 163. Subsequently, at Step S102-8, the CPU 129 judges whether the BP measurement has ended. If a negative judgment is made at Step SA102-8, the control of the CPU 129 goes back to Step S102-3 and the following steps. Meanwhile, if a positive judgment is made at Step SA102-8, the control of the CPU 129 goes to Step SA102-9 to switch the selector valve 16 to the third state to decrease the cuff pressure P k quickly, store the systolic and diastolic BP values P BPSYS , P BPDIA in an appropriate area of the RAM 133, and control a display device 32 to display the BP values P BPSYS , P BPDIA and a heart rate HR of the patient. The heart rate HR may be determined, at Step SA102-7, based on the time interval between successive two distal-side K sounds detected by the distal-side microphone 110b. As is apparent from the foregoing description, in the second BEF evaluating apparatus 108, the delay-time determining means 161 determines the delay time DT of each of the distal-side K sounds from a corresponding one of the proximal-side K sounds, and the curve providing means 162 calculates the product of the magnitude MA of each of the distal-side K sounds and a corresponding one of the delay times DT and provides the curve L connecting the respective products, along the axis indicative of the cuff pressure P k . The BP-value determining means 163 specifies two cuff-pressure values corresponding to two points on the curve L where the curve L significantly largely changes, determines one P KSYS of the two cuff-pressure values which is higher than the other, as a systolic BP value P BPSYS of the patient, and determines the other cuff-pressure value P KDIA as a diastolic BP value P BPDIA of the patient. The thus determined systolic and diastolic BP values P BPSYS , P BPDIA are used to calibrate the waveform of PPW detected by a PPW sensor 46 shown in Fig. 10. Since the curve L is obtained by connecting the plotted points corresponding to the respective products, MA x DT, the curve L exaggeratedly changes at two cuff-pressure values corresponding to systolic and diastolic BP values of the patient. Thus, the curve L is free from noise or other adverse effects resulting from, e.g., physical motion of the patient. Thus, the present apparatus 108 measures the BP values of the patient with higher accuracy than conventional apparatus. Therefore, the present apparatus 108 evaluates the blood-ejecting function of the patient with high accuracy by utilizing the accurate BP values of the patient measured before or after the patient undergoes the physical exercise. In addition, the accuracy of diagnosis of silent myocardial ischemia is improved. While at Steps SA102-3 to SA102-7 of Fig. 13 the BP values of the patient are determined based on the K sounds detected by the microphones 110a, 110b while the cuff pressure P k is slowly decreased, it is possible to determine BP values based on K sounds detected by the microphones 110a, 110b while the cuff pressure P k is slowly increased.

Claims: An apparatus (8; 108) for providing physical information relating to a blood-ejecting function of a heart of a living subject, comprising a pressure pulse wave sensor (46) which is adapted to be worn on a body portion of the subject to detect a pressure pulse wave (SM2) produced from an artery of the subject in synchronism with a heartbeat of the subject, characterized by further comprising first determining means (70) for determining a first value (EV1) of an index (EV) corresponding to a systolic area which is defined by a waveform of a first heartbeat-synchronous pulse of the pressure pulse wave detected by said pressure pulse wave sensor before the subject undergoes a-physical exercise; second determining means (72) for determining a second value (EV2) of said index corresponding to a systolic area which is defined by a waveform of a second heartbeat-synchronous pulse of the pressure pulse wave detected by said pressure pulse wave sensor after the subject undergoes said physical exercise; and a display device (32) which displays, as said physical information, the determined first and second values of said index in comparison with each other, so that an observer evaluates the blood-ejecting function of the heart of the subject based on said determined first and second values of the index displayed by said display device. An apparatus according to claim 1, further comprising evaluating means (74) for evaluating said blood-ejecting function of the heart of the subject, based on said determined first and second values of the index, and wherein said display device (32) displays information indicative of a result of evaluation of the blood-ejecting function by said evaluating means. An apparatus according to claim 1 or claim 2, further comprising: a blood pressure measuring device (62) which measures a blood pressure of the subject, said blood pressure measuring device including an inflatable cuff (10) which is adapted to be worn on the subject; and calibrating means (64) for determining a first relationship between blood pressure and magnitude of said pressure pulse wave, based on at least one magnitude of at least one heartbeat-synchronous pulse of the pressure pulse wave detected by said pressure pulse wave sensor before the subject undergoes said physical exercise, and at least one blood pressure value of the subject measured by said blood pressure measuring device before the subject undergoes said physical exercise, and determining a second relationship between blood pressure and magnitude of said pressure pulse wave, based on at least one magnitude of at least one heartbeat-synchronous pulse of the pressure pulse wave detected by said pressure pulse wave sensor after the subject undergoes said physical exercise, and at least one blood pressure value of the subject measured by said blood pressure measuring device after the subject undergoes said physical exercise, said calibrating means calibrating, according to said first relationship, said waveform of said first heartbeat-synchronous pulse and calibrating, according to said second relationship, said waveform of said second heartbeat-synchronous pulse, wherein said first determining means (70) determines said first value of the index corresponding to said systolic area defined by the calibrated waveform of said first heartbeat-synchronous pulse, and said second determining means (72) determines said second value of the index corresponding to said systolic area defined by the calibrated waveform of said second heartbeat-synchronous pulse. An apparatus according to any of claims 1 to 3, further comprising a blood-pressure measuring device (160) comprising: an inflatable cuff (10) which is adapted to be worn on the subject; a distal and a proximal microphone (110b, 110a) which are provided at a distal and a proximal position on said cuff worn on the subject, respectively, and which detect a plurality of distal arterial sounds at said distal position and a plurality of proximal arterial sounds at said proximal position, respectively, while a pressure in said cuff is changed; delay-time determining means (161) for determining a delay time of a time of detection of each of said distal arterial sounds detected by said distal microphone, from a time of detection of a corresponding one of said proximal arterial sounds detected by said proximal microphone; curve providing means (162) for determining a product of each of respective magnitudes of said distal arterial sounds and a corresponding one of the respective delay times of the distal arterial sounds, and providing a curve by connecting the respective determined products with one another along an axis indicative of said pressure of said cuff; and blood-pressure determining means (163) for determining a blood pressure of the subject based on the curve provided by said curve providing means. An apparatus (8; 108) for evaluating a blood-ejecting function of a heart of a living subject, comprising a pressure pulse wave sensor (46) which is adapted to be worn on a body portion of the subject to detect a pressure pulse wave (SM2) which is produced from an artery of the subject in synchronism with a heartbeat of the subject, characterized by further comprising first determining means (70) for determining a first value (EV1) of an index corresponding to a systolic area which is defined by a waveform of a first heartbeat-synchronous pulse of the pressure pulse wave detected by said pressure pulse wave sensor before the subject undergoes a physical exercise; second determining means (72) for determining a second value (EV2) of said index corresponding to a systolic area which is defined by a waveform of a second heartbeat-synchronous pulse of the pressure pulse wave detected by said pressure pulse wave sensor after the subject undergoes said physical exercise; and evaluating means (74) for evaluating said blood-ejecting function of the heart of the subject, based on the determined first and second values of said index. An apparatus according to claim 5, wherein said evaluating means (74) comprises first means for evaluating said blood-ejecting function of the heart of the subject, based on at least one of an amount of change of said determined second value from said determined first value and a rate of change of the determined second value from the determined first value. An apparatus according to claim 6, wherein said first means of said evaluating means (74) comprises judging means for judging whether said blood-ejecting function of the heart of the subject is normal, by comparing said one of said amount of change and said rate of change with a corresponding one of a first reference value and a second reference value. An apparatus according to any of claims 5 to 7, wherein said second determining means (72) comprises means for determining a plurality of said second values of the index each of which corresponds to a systolic area defined by a waveform of a corresponding one of a plurality of said second heartbeat-synchronous pulses of the pressure pulse wave detected by said pressure pulse wave sensor after the subject undergoes said physical exercise, and wherein said evaluating means (74) comprises second means for evaluating said blood-ejecting function of the heart of the subject, based on at least one of a time of recovering of the determined second values back to a value substantially equal to said determined first value and a rate of recovering of said determined second values back to a value substantially equal to the determined first value. An apparatus according to claim 8, wherein said second means of said evaluating means (74) comprises judging means for judging whether said blood-ejecting function of the heart of the subject is normal, by comparing said one of said time of recovering and said rate of recovering with a corresponding one of a third reference value and a fourth reference value. An apparatus according to claim 5, further comprising converting means (66) for converting said waveform of each of said first and second heartbeat-synchronous pulses, to a converted waveform, according to a predetermined mathematical transfer function defining a relationship between a waveform of a heartbeat-synchronous pulse of a pulse wave detected in an aorta of the subject and a waveform of a corresponding heartbeat-synchronous pulse of a pulse wave detected from said artery of said body portion of the subject, wherein said first determining means (70) determines said first value of the index corresponding to said systolic area defined by said converted waveform of said first heartbeat-synchronous pulse, and said second determining means (72) determines said second value of the index corresponding to said systolic area defined by said converted waveform of said second heartbeat-synchronous pulse. An apparatus according to any of claims 5 to 10, further comprising: a blood pressure measuring device (62) which measures a blood pressure of the subject, said blood pressure measuring device including an inflatable cuff (10) which is adapted to be worn on the subject; and calibrating means (64) for determining a first relationship between blood pressure and magnitude of said pressure pulse wave, based on at least one magnitude of at least one heartbeat-synchronous pulse of the pressure pulse wave detected by said pressure pulse wave sensor before the subject undergoes said physical exercise, and at least one blood pressure value of the subject measured by said blood pressure measuring device before the subject undergoes said physical exercise, and determining a second relationship between blood pressure and magnitude of said pressure pulse wave, based on at least one magnitude of at least one heartbeat-synchronous pulse of the pressure pulse wave detected by said pressure pulse wave sensor after the subject undergoes said physical exercise, and at least one blood pressure value of the subject measured by said blood pressure measuring device after the subject undergoes said physical exercise, said calibrating means calibrating, according to said first relationship, said waveform of said first heartbeat-synchronous pulse and calibrating, according to said second relationship, said waveform of said second heartbeat-synchronous pulse, wherein said first determining means (70) determines said first value of the index corresponding to said systolic area defined by the calibrated waveform of said first heartbeat-synchronous pulse, and said second determining means (72) determines said second value of the index corresponding to said systolic area defined by the calibrated waveform of said second heartbeat-synchronous pulse. An apparatus according to any of claims 5 to 11, further comprising a blood-pressure measuring device comprising: an inflatable cuff (10) which is adapted to be worn on the subject; a distal and a proximal microphone (110b, 110a) which are provided at a distal and a proximal position on said cuff worn on the subject, respectively, and which detect a plurality of distal arterial sounds at said distal position and a plurality of proximal arterial sounds at said proximal position, respectively, while a pressure in said cuff is changed; delay-time determining means (161) for determining a delay time of a time of detection of each of said distal arterial sounds detected by said distal microphone, from a time of detection of a corresponding one of said proximal arterial sounds detected by said proximal microphone; curve providing means (162) for determining a product of each of respective magnitudes of said distal arterial sounds and a corresponding one of the respective delay times of the distal arterial sounds, and providing a curve by connecting the respective determined products with one another along an axis indicative of said pressure of said cuff; and blood-pressure determining means (163) for determining a blood pressure of the subject based on the curve provided by said curve providing means.

Inventors: OKA TOHRU, TSUDA HIDEICHI, OKA, TOHRU, TSUDA, HIDEICHI, Oka, Tohru, c/o Colin Corporation, Tsuda, Hideichi, c/o Colin Corporation
Applicants: COLIN CORP, COLIN CORPORATION
Application year: 1996
Main classification: A61B5
IPC codes: A61B5