NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS

Abstract: This invention relates to novel isoxazolines and isoxazoles which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex or the vitronectin receptor, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.

Description: 3 I E Novel Isoxazoline and Isoxazole Fibrinogen Receptor Antagonists FIELD OF THE INVENTION This invention relates to novel isoxazolines and isoxazoles which are useful as antagonists of the platelet glycoprotein Ilb/IIIa fibrinogen receptor complex, to pharmaceutical compositions, including those for intranasal administration, containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders. BACKGROTIND OF THE INVENTION Hemostasis is the normal physiological process in which bleeding from an injured blood vessel is arrested. It is a dynamic and complex process in which platelets play a key role. Within seconds of vessel injury, resting platelets become activated and are bound to the exposed matrix of the injured area by a phenomenon called platelet adhesion. Activated platelets also bind to each other in a process called platelet aggregation to form a platelet plug. The platelet plug can stop bleeding quickly, but it must be reinforced by fibrin for long-term effectiveness, until the vessel injury can be permanently repaired. Thrombosis may be regarded as the pathological condition wherein improper activity of the hemostatic mechanism results in intravascular thrombus formation. Activation of platelets and the resulting platelet aggregation and platelet factor secretion has been associated with a variety of pathophysiological conditions including cardiovascular and cerebrovascular thromboembolic disorders, for example, the thromboembolic disorders associated with unstable angina, myocardial infarction, transient ischemic attack, stroke, atherosclerosis and diabetes. The contribution of platelets to these disease processes stems from their ability to form aggregates, or platelet thrombi, especially in the arterial wall following injury. Platelets are activated by a wide variety of agonists resulting in platelet shape change, secretion of granular contents and aggregation. Aggregation of platelets serves to further focus clot formation by concentrating activated clotting factors at the site of injury. Several endogenous agonists including adenosine diphosphate (ADP) , serotonin, arachidonic acid, thrombin, and collagen, have been identified. Because of the involvement of several endogenous agonists in activating platelet function and aggregation, an inhibitor which acts against all agonists would represent a more efficacious antiplatelet agent than currently available antiplatelet drugs, which are agonist- specific. Current antiplatelet drugs are effective against only one type of agonist; these include aspirin, which acts against arachidonic acid; ticlopidine, which acts against ADP; thromboxane A synthetase inhibitors or receptor antagonists, which act against thromboxane A ; and hirudin, which acts against thrombin. Recently, a common pathway for all known agonists has been identified, namely platelet glycoprotein Ilb/IIIa complex (GPIIb/IIIa) , which is the membrane protein mediating platelet aggregation. A recent review of GPIIb/IIIa is provided by Phillips et al. Cell (1991) 65: 359-362. The development of a GPIIb/IIIa antagonist represents a promising new approach for antiplatelet therapy. GPIIb/IIIa does not bind soluble proteins on unstimulated platelets, but GPIIb/IIIa in activated platelets is known to bind four soluble adhesive proteins, namely fibrinogen, von Willebrand factor, fibronectin, and vitronectin. The binding of fibrinogen and von Willebrand factor to GPIIb/IIIa causes platelets to aggregate. The binding of fibrinogen is mediated in part by the Arg-Gly- Asp (RGD) recognition sequence which is common to the adhesive proteins that bind GPIIb/IIIa. In addition to GPIIb/IIIa, increasing numbers of other cell surface receptors have been identified which bind to extracellular matrix ligands or other cell adhesion ligands thereby mediating cell-cell and cell-matrix adhesion processes. These receptors belong to a gene superfamily called integrins and are composed of heterodimeric transmembrane glycoproteins containing α- and β-subunits. Integrin subfamilies contain a common β- subunit combined with different α-subunits to form adhesion receptors with unique specificity. The genes for eight distinct β-subunits have been cloned and sequenced to date. Two members of the βl subfamily, α4/βiand α5/βi have been implicated in various inflammatory processes. Antibodies to α4 prevent adhesion of lymphocytes to synovial endothelial cells in vitro, a process which may be of importance in rheumatoid arthritis (VanDinther- Janssen et al., J. Immunol., 1991, 147:4207). Additional studies with monoclonal anti-α4 antibodies provide evidence that α4/βl may additionally have a role in allergy, asthma, and autoimmune disorders (Walsh et al., J. Immunol., 1991, 146:3419; Bochner et al. , J. Exp. Med., 1991 173:1553; Yednock et al., Nature, 1992, 356:63). Anti-α4 antibodies also block the migration of leukocytes to the site of inflammation (Issedutz et al., J. Immunol. 1991, 147:4178) . The α v /β 3 heterodimer, commonly referred to as the vitronectin receptor, is another member of the β 3 integrin subfamily and has been described in platelets, endothelial cells, melanoma, smooth muscle cells and on the surface of osteoclasts (Horton and Davies, J. Bone Min. Res. 1989, 4:803-808; Davies et al. , J. Cell. Biol. 1989, 109:1817- 1826; Horton, Int. J. Exp. Pathol., 1990, 71:741-759). Like GPIIb/IIIa, the vitronectin receptor binds a variety of RGD-containing adhesive proteins such as vitronectin, fibronectin, VWF, fibrinogen, osteopontin, bone sialo protein II and thrombospondin in a manner mediated by the RGD sequence. Possible roles for α v /β 3 in angiogenesis, tumor progression, and neovascularization have been proposed (Brooks et al., Science, 1994, 264:569-571). A key event in bone resorption is the adhesion of osteoclasts to the matrix of bone. Studies with monoclonal antibodies have implicated the α v /β 3 receptor in this process and suggest that a selective α v /β3 antagonist would have utility in blocking bone resorption (Horton et al., J. Bone Miner. Res., 1993, 8:239-247; Helfrich et al., J. Bone Miner. Res., 1992, 7:335-343). Several RGD-peptidomimetic compounds have been reported which block fibrinogen binding and prevent the formation of platelet thrombi. European Patent Application Publication Number 478363 relates to compounds having the general formula: European Patent Application Publication Number 478328 relates to compounds having the general formula: European Patent Application Publication Number 525629 (corresponds to Canadian Patent Application Publication Number 2,074,685) discloses compounds having the general formula: PCT Patent Application 9307867 relates to compounds having the general formula: European Patent Application Publication Number 4512831 relates to compounds having the general formula: X-(CH 2 ) m -Y-(CH 2 ) k -C-NH-CH-CH-Z O R 1 None of the above references teaches or suggests the compounds of the present invention which are described in detail below. Most peptides and peptidomimetics exhibit very low oral bioavailability due to poor absorption and/or degradation in the GI tract and liver. Therefore, their use is limited to the parenteral route of administration. Drugs with low bioavailability often have a large variability in pharmacological response due to an associated variability in drug delivery. This large variability in drug delivery may occur when the bioavailability is low because under those conditions, it takes only a small variation in bioavailability to give a large change in plasma drug concentration (W. K. Sietsema, The Absolute Oral Bioavailability of Selected Drug, International Journal of Clinical Pharmacology, Therapy and Toxicology, Vol. 27 No. 4 - 1989 (179-211)). Peptides and peptidomimetics have also generally shown relatively low nasal bioavailability. For example, studies with the luteinizing hormone releasing hormone (LHRH) analog, nafarelin acetate, showed that nasal bioavailability was only - 2% (S. T. Anik, G. McRae, C. Nerenberg, A. Worden, J. Foreman, J. Hwang, S. Kushinsky, R. E. Jones, and B. Vickery; J. Pharm., Sci. 73: 684-685 (1984)). Thus, the intranasal administration of peptides and peptidomimetics is generally not recommended. SUMMARY OF THE INVENTION The present invention provides novel nonpeptide compounds which bind to integrin receptors thereby altering cell-matrix and cell-cell adhesion processes. The compounds of the present invention are useful for the treatment of inflammation, bone degradation, tumors, metastases, thrombosis, and cell aggregation-related conditions in a mammal. One aspect of this invention provides novel compounds of Formula I (described below) which are useful as antagonists of the platelet glycoprotein Ilb/IIIa complex. The compounds of the present invention inhibit the binding of fibrinogen to platelet glycoprotein Ilb/IIIa complex and inhibit the aggregation of platelets. The present invention also includes pharmaceutical compositions containing such compounds of Formula I, and methods of using such compounds for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders. The present invention also includes methods of treating cardiovascular disease, thrombosis or harmful platelet aggregation, reocclusion following thrombolysis, reperfusion injury, or restenosis by administering a compound of Formula I alone or in combination with one or more additional therapeutic agents selected from: anti-coagulants such as warfarin or heparin; anti-platelet agents such as aspirin, piroxicam or ticlopidine; thrombin inhibitors such as boroarginine derivatives, hirudin or argatroban; or thrombolytic agents such as tissue plasminogen activator, anistreplase, urqkinase or streptokinase; or combinations thereof. The present invention also provides novel compounds, pharmaceutical compositions and methods which may be used in the treatment or prevention of diseases which involve cell adhesion processes, including, but not limited to, rheumatoid arthritis, asthma, allergies, adult respiratory distress syndrome, graft versus host disease, organ transplantation, septic shock, psoriasis, eczema, contact dermatitis, osteoporosis, osteoarthritis, atherosclerosis, metastasis, wound healing, diabetic retinopathy, inflammatory bowel disease and other autoimmune diseases. Also included in the present invention are pharmaceutical kits comprising one or more containers containing pharmaceutical dosage units comprising a compound of Formula I, for the treatment of cell adhesion related disorders, including but not limited to thromboembolic disorders. DETAILED DESCRIPTION OF THE INVENTION The present invention provides novel nonpeptide compounds of Formula I (described below) which bind to integrin receptors thereby altering cell-matrix and cell- cell adhesion processes. The compounds of the preseπit invention are useful for the treatment of inflammation, bone degradation, tumors, metastases, thrombosis, and cell aggregation-related conditions in a mammal. One aspect of this invention provides compounds of Formula I (described below) which are useful as antagonists of the platelet glycoprotein Ilb/IIIa complex. The compounds of the present invention inhibit the binding of fibrinogen to the platelet glycoprotein Ilb/IIIa complex and inhibit the aggregation of platelets. The present invention also includes pharmaceutical compositions containing such compounds of Formula I, and methods of using such compounds for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders. This invention relates to novel compounds of the Formula I: or a pharmaceutically acceptable salt or prodrug form thereof. [1] A first embodiment of this invention provides compounds of Formula I: or pharmaceutically acceptable salt or prodrug forms thereof wherein: b is a single or double bond; R 1 is selected from R 2 (R 3 )N(CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)CN(R 2 ) (CH 2 ) q Z-, piperazinyl- (CH ) q Z- or Z is selected from 0, S, S(=0), or S(=0) 2 ; R 2 and R 3 are independently selected from: H, Ci-Cio alkyl, C 2 -Cg alkenyl, C3-C11 cycloalkyl, C4-C11 cycloalkylalkyl, Cβ-Cio aryl, C7-C11 arylalkyl, C 2 -C7 alkylcarbonyl, Cβ-Cio arylcarbonyl, C 2 -Cιo alkoxycarbonyl, C 4 -C 11 cycloalkoxycarbonyl, C 7 -C 11 bicycloalkoxycarbonyl, C 6 -C 10 aryloxycarbonyl, aryl (C 1 -C 10 alkoxy)carbonyl, C 3. -C 6 alkylcarbonyloxy(C 1 -C 4 alkoxy) carbonyl, C 6 -C 10 arylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl, C 4 -C 11 cycloalkylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl; U is selected from: a single bond (i.e., U is not present), -(C 1 -C 7 alkyl)-, -(C 2 -C 7 alkenyl)-, -(C 2 -C 7 alkynyl)-, -(aryl)- substituted with 0-3 R 6a , or -(pyridyl)- substituted with 0-3 R 6a ; V is selected from: a single bond (i.e., V is not present); -(C 1 -C 7 alkyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(C 2 -C 7 alkenyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(C2-C 7 alkynyl)-, substituted with 0-2 groups independently selected from R 6 or R 7 ; -(aryl)-, substituted with 0-2 groups independently selected from R 6 or R 7 ; -(pyridyl)-, substituted with 0-2 groups independently selected from R 6 or R 7 ; or -(pyridazinyl) -, substituted with 0-2 groups independently selected from R 6 or R 7 ; W is selected from: a single bond (i.e., W is not present), -(C 1 -C7 alkyl)-, -{C 2 -C 7 alkenyl)-, -(C 2 -C 7 alkynyl)-, or -(C(R 5 ) 2 ) n C(=0)N(R 5a )-; X is selected from: a single bond (i.e., X is not present); -(C 1 -C 7 alkyl)-, substituted with 0-3 groups independently selected from R 4 , R 8 or R 14 ; -(C 2 -C 7 alkenyl)-, substituted with 0-3 groups independently selected from R 4 , R 8 or R 14 ; -(C 2 -C 7 alkynyl)-, substituted with 0-2 groups independently selected from R 4 , R 8 or R 14 ; or Y is selected from hydroxy, Ci to Cio alkyloxy, C 3 to Cn cycloalkyloxy, Cζ to Cio aryloxy, C7 to Cn aralkyloxy, C 3 to Cio alkylcarbonyloxyalkyloxy, C 3 to Cio alkoxycarbonyloxyalkyloxy, C 2 to Cio alkoxycarbonylalkyloxy, C 5 to Cio cycloalkylcarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonyloxyalkyloxy, C5 to Cio cycloalkoxycarbonylalkyloxy, C 7 to Cn aryloxycarbonylalkyloxy, Cs to C 12 aryloxycarbonyloxyalkyloxy, Cs to C 12 arylcarbonyloxyalkyloxy, C 5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C5 to Cio (5-alkyl- l,3-dioxa-cyclopenten-2-one-yl)methyloxy, Cio to C14 (5-aryl-l,3-dioxa-cyclopenten-2-one-yl)methyloxy; or (R 2 ) (R 3 )N-(Cι-Cιo alkoxy)-; R 4 and R b are independently selected from H, C 1 -C 10 alkyl, hydroxy, C 1 -C 10 alkoxy, nitro, C 1 -C 10 alkylcarbonyl, or -N(R 12 )R 13 ; R 5 is selected from H, Ci-Cs alkyl, C 2 -C6 alkenyl, C3-C 1 1 cycloalkyl, C 4 -C 11 cycloalkylmethyl, Cβ-Cio aryl, C7- C 11 arylalkyl, or C 1 -C 10 alkyl substituted with 0-2 R 4b ; R 5 is selected from hydrogen, hydroxy, Ci to Cs alkyl, C2 to C δ alkenyl, C3 to Cn cycloalkyl, C4 to Cn cycloalkylmethyl, C 1 -C6 alkoxy, benzyloxy, C δ to Cio aryl, heteroaryl, heteroarylalkyl, C 7 to Cn arylalkyl, adamantylmethyl or C 1 -C 10 alkyl substituted with 0-2 R b ; alternately, R 5 and R 5a can be taken together to be 3- azabicyclononyl, 1-piperidinyl, 1-morpholinyl or 1- piperazinyl, each being optionally substituted with Ci-Ce alkyl, C 6 -C 10 aryl, heteroaryl, C 7 -C 11 arylalkyl, Ci-Cβ alkylcarbonyl, C 3 -C 7 cycloalkylcarbonyl, Ci-Cβ alkoxycarbonyl, C 7 -C11 arylalkoxycarbonyl, Ci-Cβ alkylsulfonyl or Cβ-Cio arylsulfonyl; R 5b is selected from Ci-Cs alkyl, C 2 -C6 alkenyl, C 3 -C 11 cycloalkyl, C 4 -C 11 cycloalkylmethyl, Cβ-Cio aryl, C7- C 11 arylalkyl, or C 1 -C 10 alkyl substituted with 0-2 R 4b ; R 6 is selected from H, C1-C10 alkyl, hydroxy, C1-C10 alkoxy, nitro, C 1 -C 10 alkylcarbonyl, -N(R 12 )R 13 , cyano, halo, CF 3 , CHO, CO2R 5 , C(=0)R 5a , C0NR 5 R 5a , OC(=0)R 5a , OC(=0)OR 5b , OR 5a , OC(=0)NR 5 R 5a , 0CH 2 C0 2 R 5 , C0 2 CH 2 C0 2 R 5 , NR 5 C(=0)R 5a , NR 5a C (=0)OR 5b , NR 5a C(=0)NR 5 R 5a , NR 5a S0 NR 5 R 5a , NR 5a S0 2 R 5 , S(0) p R 5a , S0 2 NR 5 R 5a , C 2 -C 6 alkenyl, C 3 -C 11 cycloalkyl, C 4 -C 11 cycloalkylmethyl; β to Cio aryl optionally substituted with 1-3 groups selected from halogen, Ci-Cβ alkoxy, Ci-Cβ alkyl, CF3, S(0)mMe, or -NMe2; C 7 to Cn arylalkyl, said aryl being optionally substituted with 1-3 groups selected from halogen, Ci-Cβ alkoxy, Ci-Cβ alkyl, CF 3 , S(0)mMe, or -NMe2; methylenedioxy when R 6 is a substituent on aryl; or a 5-10 membered heterocyclic ring containing 1-3 N, 0, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 7 ; R 6a is selected from C 1 -C 4 alkyl, C 1 -C4 alkoxy, halo, CF 3 , N0 2 , or NR 12 R 13 ; R 7 is selected from H, C 1 -C 10 alkyl, hydroxy, C 1 -C 10 alkoxy, nitro, C 1 -C 10 alkylcarbonyl, -N(R 12 )R 13 , cyano, halo, CF 3 , CHO, C0 2 R 5 , C(=0)R 5a , C0NR 5 R 5 , OC(=0)R 5a , OC(=0)OR 5b , OR 5a , OC(=0)NR 5 R 5a , 0CH 2 C0 2 R 5 , Cθ2CH 2 C0 2 R 5 , N0 2 , NR 5 C (=0)R 5 , NR 5a C (=0)OR 5b , NR 5 C(=0)NR 5 R 5a , NR 5a S0 2 NR 5 R 5 , NR 5a S0 2 R 5 , S(0) p R 5 , S0 2 NR 5 R 5a , C 2 -C6 alkenyl, C3-C 1 1 cycloalkyl, C4-C 11 cycloalkylmethyl, C 6 -C 10 aryl, or C 7 -C 11 arylalkyl; R 8 is selected from: H; R 6 ; C 1 -C 10 alkyl, substituted with 0-3 R 6 ; C 2 -C1 0 alkenyl, substituted with 0-3 R 6 ; C 2 -C 10 alkynyl, substituted with 0-3 R 6 ; C 3 -C 8 cycloalkyl, substituted with 0-3 R 6 ; C 5 -C 6 cycloalkenyl, substituted with 0-2 R 6 ; aryl, substituted with 0-2 R 6 ; 5-10 membered heterocyclic ring containing 1-3 N, 0, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R G ; R 12 and R 13 are independently H, Ci-Cio alkyl, Ci-Cio alkoxycarbonyl, Ci-Cio alkylcarbonyl, Ci-Cio alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, arylsulfonyl, aryl, C 2 -C 6 alkenyl, C 3 -C 11 cycloalkyl, C4-C 1 1 cycloalkylalkyl, C7-C 11 arylalkyl, C 2 -C 7 alkylcarbonyl, C7-C 11 arylcarbonyl, C 2 -C1 0 alkoxycarbonyl, C4-C 11 cycloalkoxycarbonyl, C 7 -C11 bicycloalkoxycarbonyl, C 7 -C 11 aryloxycarbonyl, heteroarylcarbonyl, heteroarylalkylcarbonyl or aryl (C 1 -C 10 alkoxy)carbonyl; R 14 is selected from H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C2- C 1 0 alkynyl, C 1 -C 10 alkoxy, aryl, heteroaryl or C 1 -C10 alkoxycarbonyl, CO 2 R 5 or -C (=0)N(R 5 )R 5a ; R 15 is selected from: H; R 6 ; C 1 -C 10 alkyl, substituted with 0-8 R 6 ; C2-C1 0 alkenyl, substituted with 0-6 R 6 ; C 1 -C 10 alkoxy, substituted with 0-6 R 6 ; aryl, substituted with 0-5 R 6 ; 5-6 membered heterocyclic ring containing 1-2 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-5 R 6 ; C 1 -C 10 alkoxycarbonyl substituted with 0-8 R δ ; CO2R 5 ; or -C(=0)N(R 5 )R 5a ; n is 0-4; q is 2-7 r is 0-3 provided that when b is a double bond, only one of R 14 or R 15 is present; provided that n, q, and r are chosen such that the number of in-chain atoms between R 1 and Y is in the range of 8-18. [2] Preferred compounds of this first embodiment are those of Formula II (where W is a single bond (i.e. absent) and U is a single bond (i.e., absent)): wherein : R 1 is selected from R 2 HN(CH 2 ) q O-, R 2 HN(R 2 N=)CNH(CH 2 ) q O-, piperazinyl-(CH 2 ) q O-, or R 2 is selected from H, aryl(Cι-Cιo alkoxy)carbonyl, Ci-Cio alkoxycarbonyl; and/or R 8 is selected from H, Ci-Cio alkyl, C 2 -Cιo alkenyl, C 3 - Cs cycloalkyl, C 5 -C 6 cycloalkenyl, aryl, 5-6 membered heterocyclic ring containing 1-2 N, 0, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated; and/or R 6 and R 7 are selected from H, C 1 -C 10 alkyl, hydroxy, C 1 -C 10 alkoxy, nitro, C 1 -C 10 alkylcarbonyl, -N(R 12 )R 13 , cyano, or halo. [3] Further preferred compounds of this first embodiment are those of Formula II (where W is a bond/absent and U is a bond/absent) : wherein : X is selected from: a single bond (i.e., X is not present); -(C 1 -C 7 alkyl)-, substituted with 0-2 groups independently selected from R 4 , R 8 or R 14 ; -(C 2 -C 7 alkenyl)-, substituted with 0-2 groups independently selected from R 4 , R 8 or R 14 ; -(C 2 -C 7 alkynyl)-, substituted with 0-2 groups independently selected from R 4 , R 8 or R 14 ; and/or R 8 is selected from H, C 1 -C6 alkyl, C 2 -C6 alkenyl, C3-C8 cycloalkyl, C 5 -C6 cycloalkenyl, aryl, 5-6 membered heterocyclic ring containing 1-2 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated. [4] Further preferred compounds of this first embodiment are compounds of Formula II wherein: V is phenylene or pyridylene; n is 1 or 2; X is -(C 1 -C 2 )alkyl- substituted with 0-2 R 4 Y is selected from: hydroxy; Ci to Cio alkoxy; methylcarbonyloxymethoxy-; ethylcarbonyloxymethoxy-; t-butylcarbonyloxymethoxy-; cyclohexylcarbonyloxymethoxy-; 1-(methylcarbonyloxy)ethoxy-; 1-(ethylcarbonyloxy)ethoxy-; 1-(t-butylcarbonyloxy)ethoxy-; 1-(cyclohexylcarbonyloxy)ethoxy-; i-propyloxycarbonyloxymethoxy-; t-butyloxycarbonyloxymethoxy-; 1- (i-propyloxycarbonyloxy)ethoxy-; 1- (cyclohexyloxycarbonyloxy)ethoxy-; 1-(t-butyloxycarbonyloxy)ethoxy-; dimethylaminoethoxy-; diethylaminoethoxy-; (5-methyl-l,3-dioxacyclopenten-2-on-4-yl)methoxy-; (5- (t-butyl)-1,3-dioxacyclopenten-2-on-4-y1)methoxy-; (l;3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methoxy-; 1-(2-(2-methoxypropyl)carbonyloxy)ethoxy-; R 4 is -NR 12 R 13 ; R 12 is H, C 1 -C 4 alkoxycarbonyl, C 1 -C 4 alkylcarbonyl, C 1 -C 4 alkylsulfonyl, arylalkylsulfonyl, arylsulfonyl, benzyl, benzoyl, phenoxycarbonyl, benzyloxycarbonyl, arylalkylsulfonyl, pyridylcarbonyl, or pyridylmethylcarbonyl; and R 13 is H. [5] Specifically preferred compounds of this first embodiment are compounds, or pharmaceutically acceptable salt or prodrug forms thereof, selected from: 5 (R, S)-3-[ [4-(2-piperidin-4-yl)ethoxyphenyl]isoxazolin-5- yl]acetic acid; 5 (R, S) -N-(butanesulfonyl)-L-{3-[4-(2-piperidin-4- yl)ethoxyphenyl]isoxazolin-5-y1}glycine; 5 (R, S) -N-(α-toluenesulfonyl)-L-{3-[4-(2-piperidin-4- yl)ethoxyphenyl]isoxazolin-5-yl}glycine; 5 (R, S) -N- [ (benzyloxy)carbonyl] -L-{3- [4- (2-piperidin-4- yl) ethoxyphenyl] isoxazolin-5-y1}glycine; 5 (R, S) -N- (pentanoyl) -L-{3-[4- (2-piperidin-4-yl)ethox¬ yphenyl] isoxazolin-5-yl}glycine; 5 (R, S) -3-{ [4- (piperidin-4-yl) ethoxyphenyl] isoxazolin-5- yDpropanoic acid; 2 (R, S) -5 (R, S) -N- (butanesulfonyl)amino-{3- [4- (piperidin-4- yl)methoxyphenyl] isoxazolin-5-yl}propanoic acid; 2 (R, S) -5 (R, S) -N- (α-toluenesulfonyl)amino-{3- [4- (piperi- din-4-yl) ethoxyphenyl] isoxazolin-5-yl}propanoic acid; 2 (R, S) -5 (R, S) -N- [ (benzyloxy) carbonyl]amino-{3- [4- (piper- idin-4-yl)methoxyphenyl] isoxazolin-5-yl}propanoic acid; 2 (R, S) -5 (R, S) -N- (pentanoyl)amino-{3- [4- (piperidin-4- yl)methoxyphenyl] isoxazolin-5-yl}propanoic acid. [6] A second embodiment of this invention provides a compound of Formula I: or a pharmaceutically acceptable salt or prodrug form thereof wherein: b is a single or double bond; R 1 is selected from R 2a (R 3 )N-, R 2 (R 3 )N(R 2 N=)C-, R 2a (R 3 )N(CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)C (CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)CN(R 2 )-, R 2 (R 3 )NC (O) -, R 2 (R 5 0)N(R 2 N=)C- or R 2 (R 3 )N(R 5 ON=)C-; Z is selected from a bond (i.e. is absent), O, S, S(=0), S(=0) 2 ; R 2 and R 3 are independently selected from: H; Ci-Cio alkyl; C 3 -C6 alkenyl; C 3 -C 11 cycloalkyl; C4-C11 cycloalkylalkyl; Cβ-Cio aryl optionally substituted with 0-3 groups selected from hydroxy, halogen, C 1 -C 6 alkoxy, Cι-C 6 alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 7 - C 11 arylalkyl optionally substituted with 0-3 groups selected from hydroxy, halogen, C -Cς, alkoxy, Ci-Cβ alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C1-C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 2 -C 7 alkylcarbonyl; C 7 -C 11 arylcarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cβ alkoxy, Ci-C δ alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 1 -C 10 alkoxycarbonyl; C 4 -C 11 cycloalkoxycarbonyl; C7-C 11 bicycloalkoxycarbonyl; C7- C 1 1 aryloxycarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cβ alkoxy, Ci-Ce alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; aryl (C 1 -C 10 alkoxy) carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cβ alkoxy, Ci-Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C1-C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; Ci-Cβ alkylcarbonyloxy(C 1 -C 4 alkoxy) carbonyl; Cβ-Cio arylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cβ alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 4 -C11 cycloalkylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl; heteroaryl optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-Cg alkoxy, C1-C6 alkyl, CF3, S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; or heteroaryl (C 1 -C 5 )alkyl where the heteroaryl group is optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-Cg alkoxy, C 1 -C 6 alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 )2, C 1 -C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; provided that only one of R 2 and R 3 may be hydroxy; R 2a is R 2 or R 2 (R 3 )N(R 2 N=)C-; U is selected from: a single bond (i.e., U is not present), -(C 1 -C 7 alkyl)-, -(C2-C7 alkenyl)-, -(C2-C7 alkynyl)-, -(aryl)- substituted with 0-3 R 6 , or -(pyridyl)- substituted with 0-3 R 6 ; V is selected from: a single bond (i.e., V is not present); -(C 1 -C 7 alkyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(C 2 -C 7 alkenyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(C 2 -C 7 alkynyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; - (phenyl) -Q-, said phenyl substituted with 0-2 groups independently selected from R 6 or R 7 ; - (pyridyl) -Q-, said pyridyl substituted with 0-2 groups independently selected from R 6 or R 7 ; or - (pyridazinyl) -Q-, said pyridazinyl substituted with 0-2 groups independently selected from R 6 or R 7 ' Q is selected from: a single bond (i.e., Q is not present), -0-, -S(0) m -, -N(R 12 )-, -(CH 2 )m-, -C(=0)-, -N(R 5 )C(=0)-, -C(=0)N(R 5a )-, -CH 2 0-, -0CH 2 -, -CH 2 N(R 12 )-, -N(R 12 )CH 2 -, -CH 2 C(=0)-, -C(=0)CH 2 -, -CH 2 S(0) m -, or -S(0) m CH 2 -, provided that when b is a single bond, and R 1 -U-V- is a substituent on C5 of the central 5-membered ring of Formula I, then Q is not -0-, -S(0) m -, -N(R 12 )-, -C(=0)N(R 5a )-, -CH 2 0-, CH 2 N(R 12 )- or -CH 2 S(0)π,-; W is selected from: -(C(R ) 2 ) n C(=0)N(R 5 )-, or -C ( =0)-N ( R 5a) -(C ( R ) 2 ) n -; X is selected from: a single bond (i.e. X is absent) - -(C(R ) 2 )n-C(R 4 ) (R 8 )-C(R 4 ) (R a )-, with the proviso that when n is 0 or 1, then at least one of R 4a or R 8 is other than H or methyl; Y is selected from hydroxy, Ci to Cio alkyloxy, C3 to Cn cycloalkyloxy, β to Cio aryloxy, C 7 to Cn aralkyloxy, C 3 to Cio alkylcarbonyloxyalkyloxy, C 3 to Cio alkoxycarbonyloxyalkyloxy, C 2 to Cio alkoxycarbonylalkyloxy, C 5 to Cio cycloalkylcarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonylalkyloxy, C7 to Cn aryloxycarbonylalkyloxy, Cs to C 12 aryloxycarbonyloxyalkyloxy, Cs to C 12 arylcarbonyloxyalkyloxy, C 5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C 5 to Cio (5-alkyl- l,3-dioxa-cyclopenten-2-one-yl)methyloxy, Cio to C 14 (5-aryl-l,3-dioxa-cyclopenten-2-one-yl)methyloxy, (R 2 ) (R 3 )N-(Cι-Cιo alkoxy)-; R 4 is selected from H, Ci-Cio alkyl, Ci-Cio alkylcarbonyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; alternately, two R 4 groups on adjacent carbons may join to form a bond (i.e. a carbon-carbon double or triple bond) ; R 4 is selected from H, hydroxy, Ci-Cio alkoxy, nitro, N(R 5 )R 5a , -N(R 12 )R 13 , -N(R 16 )Rl 7 , Ci-Cio alkyl substituted with 0-3 R 6 , aryl substituted with 0-3 R 6 , heteroaryl substituted with 0-3 R 6 or Ci-Cio alkylcarbonyl; R 4b is selected from H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C -C 6 alkynyl, C 3 -C 7 cycloalkyl, C 7 -C 14 bicycloalkyl, hydroxy, Ci-Cβ alkoxy, Ci-C δ alkylthio, Ci-Cδ alkylsulfinyl, Ci-Cε alkylsulfonyl, nitro, Ci-Cβ alkylcarbonyl, C δ -Cio aryl, -N(R 12 )R 13 ; halo. CF 3/ CN, Ci-C δ alkoxycarbonyl, carboxy, piperidinyl, morpholinyl or pyridinyl; R 5 is selected from H, Ci-Cs alkyl, C 3 -C 6 alkenyl, C 3 -C 11 cycloalkyl, C 4 -C 11 cycloalkylmethyl, Cβ-Cio aryl, C 7 - C 11 arylalkyl, or C 1 -C 10 alkyl substituted with 0-2 R 4 ; R 5 is selected from hydrogen, hydroxy, C to Cs alkyl, C 3 - Cβ alkenyl, C 3 to Cn cycloalkyl, C 4 to Cn cycloalkylmethyl, Ci-Cβ alkoxy, benzyloxy, Cβ to Cio aryl, heteroaryl, heteroarylalkyl, C 7 to Cn arylalkyl, adamantylmethyl, or C 1 -C 10 alkyl substituted with 0-2 R b ; alternately, R 5 and R 5a when both are substituents on the same nitrogen atom (as in -NR 5 R 5a ) can be taken together with the nitrogen atom to which they are attached to form 3-azabicyclononyl, 1,2,3,4- tetrahydro-1-quinolinyl, 1,2,3, 4-tetrahydro-2- isoquinolinyl, 1-piperidinyl, 1-morpholinyl, 1- pyrrolidinyl, thiamorpholinyl, thiazolidinyl or 1- piperazinyl, each being optionally substituted with Ci-C δ alkyl, Cβ-Cio aryl, heteroaryl, C 7 -C 1 1 arylalkyl, Ci-Cβ alkylcarbonyl, C3-C7 cycloalkylcarbonyl, C1-C6 alkoxycarbonyl, C7-C11 arylalkoxycarbonyl, Ci-Cβ alkylsulfonyl or C δ -Cio arylsulfonyl; R 5b is selected from Ci-Cβ alkyl, C -Cβ alkenyl, C 3 -C 11 cycloalkyl, C 4 -C 11 cycloalkylmethyl, Cε-Cio aryl, C7- C 11 arylalkyl, or C 1 -C 10 alkyl substituted with 0-2 R ; R 6 is selected from H, C 1 -C 10 alkyl, hydroxy, C 1 -C 10 alkoxy, nitro, C 1 -C 10 alkylcarbonyl, -N(R 12 )R 13 , cyano, halo, CF 3 , CHO, C0 2 R 5 , C(=0)R 5a , CONR 5 R 5a , OC(=0)R 5a , OC(=0)OR 5b , OR 5a , OC(=0)NR 5 R 5 , OCH 2 CO 2 R 5 , Cθ 2 CH2C0 2 R 5 , N0 2 , NR 5a C (=0)R 5a , NR 5a C(=0)OR 5b , NR 5 C(=0)NR 5 R 5a , NR 5a S0 2 NR 5 R 5a , NR 5a S0 2 R 5 , S(0) m R 5 , S0 2 NR 5 R 5 , SiMe 3 , C 2 to C alkenyl, C 3 to Cn cycloalkyl, C4 to Cn cycloalkylmethyl; Cβ to Cio aryl optionally substituted with 1-3 groups selected from halogen, Ci-Cg alkoxy, C 1 -C 6 alkyl, CF 3 , S(0)mMe, or -NMe 2 ; C 7 to Cn arylalkyl, said aryl being optionally substituted with 1-3 groups selected from halogen, Ci-Ce alkoxy, Ci-Cβ alkyl, CF 3 , S(0)mMe, or -NMe 2 ; methylenedioxy when R 6 is a substituent on aryl; or a 5-10 membered heterocyclic ring containing 1-3 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 7 ; R 6a is selected from C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , N0 2 , or NR 12 R 13 ; R 7 is selected from H, Ci-Cio alkyl, hydroxy, Ci-Cio alkoxy, nitro, Ci-Cio alkylcarbonyl, -N(R 12 )R 13 , cyano, halo, CF 3 , CHO, C0 2 R 5 , C(=0)R 5a , CONR 5 R 5 , OC(=0)R 5a , OC(=0)OR 5b , OR 5 , OC(=0)NR 5 R 5 , OCH Cθ 2 R 5 , CO2CH2CO2R 5 , N0 2 , NR 5 C(=0)R 5 , NR 5a C(=0)OR 5b , NR 5a C(=0)NR 5 R 5a , NR 5a S02NR 5 R 5a , NR 5a S0 2 R 5 , S(0) m R 5a , S0 NR 5 R 5a , C to Cβ alkenyl, C 3 to Cn cycloalkyl, C 4 to Cn cycloalkylmethyl, Cβ to Cio aryl, or C 7 to Cn arylalkyl; R 8 is selected from: R 6 ; C 1 -C 10 alkyl, substituted with 0-3 R 6 ; C 2 -C 10 alkenyl, substituted with 0-3 R 6 ; C 2 -C 10 alkynyl, substituted with 0-3 R 6 ; C 3 -C 8 cycloalkyl, substituted with 0-3 R 6 ; C 5 -C 6 cycloalkenyl, substituted with 0-3 R 6 ; aryl, substituted with 0-3 R 6 ; 5-10 membered heterocyclic ring containing 1-3 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 6 ; R 12 and R 13 are independently H, C 1 -C 10 alkyl, C 1 -C 1 0 alkoxycarbonyl, C 1 -C 10 alkylcarbonyl, C1-C 10 alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, arylsulfonyl, aryl(C 2 -Cιo alkenyl)sulfonyl, heteroarylsulfonyl, aryl, C 2 -C 6 alkenyl, C 3 -C 11 cycloalkyl, C 4 -C 11 cycloalkylalkyl, C 7 -C 11 arylalkyl, C 7 -C 11 arylcarbonyl, C 4 -C 11 cycloalkoxycarbonyl, C7- Cn bicycloalkoxycarbonyl, C 7 -C 11 aryloxycarbonyl, heteroarylcarbonyl, heteroarylalkylcarbonyl, or aryl (C1-C 10 alkoxy) carbonyl, wherein said aryls are optionally substituted with 0-3 substituents selected from the group consisting of: C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , and NO 2 ; R 14 is selected from H, Ci-Cio alkyl, C 2 -C 10 alkenyl, C 2 - C10 alkynyl, C 1 -C 10 alkoxy, aryl, heteroaryl or C 1 -C 1 0 alkoxycarbonyl, CO2R 5 or -C(=0)N(R 5 )R 5 ; R 15 is selected from: H; R 6 ; -C0 2 R 5 ; -C (=0)N(R 5 )R 5 ; C1-C10 alkoxycarbonyl substituted with 0-2 R 6 ; C1-C10 alkyl, substituted with 0-3 R 6 ; C 2 -C1 0 alkenyl, substituted with 0-3 R 6 ; C 1 -C1 0 alkoxy, substituted with 0-3 R 6 ; aryl, substituted with 0-3 R 6 ; or 5-10 membered heterocyclic ring containing 1-3 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 6 ; provided that when b is a double bond, only one of R 14 or R 15 is present; R 16 is selected from: . , -C(=0)-0-R 18a , -C(=0)-R 18b , -C(=0)N(R 18b ) 2 , -C(=0)NHS0 2 R 18a , -C(=0)NHC(=0)R 18b , -C(=0)NHC(=0)OR 18 , -C(=0)NHS0 2 NHR 18b , -C(=S)-NH-R 18b , -NH-C(=0)-0-R 18a , -NH-C(=0)-R 18b , -NH-C(=0)-NH-R 18b , -S0 2 -0-R 18a , -S0 2 -R 18a , -S0 2 -N(18 b ) 2 , -S0 2 -NHC(=0)018 b , -P(=S ) (OR 18a ) 2 , -P(=0) (OR 18a ) 2 , -P(=S) (R 18a ) 2 , -P(=0) (R 18a ) 2 , or R 17 is selected from: H, Ci-Cio alkyl, C 2 -C 6 alkenyl, C 3 -C 11 cycloalkyl, C 4 -C 15 cycloalkylalkyl, aryl, aryl(Cι-Cιo alkyl)-; R 18a is selected from: Cι-C 8 alkyl substituted with 0-2 R 19 , C 2 -C8 alkenyl substituted with 0-2 R 19 , C 2 -Cs alkynyl substituted with 0-2 R 19 , C 3 -C 8 cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-4 R 19 , aryl(Cι-C 6 alkyl)- substituted with 0-4 R 19 , a 5-10 membered heterocyclic ring system having 1-3 heteroatoms selected independently from 0, S, and N, said heterocyclic ring being substituted with 0-4 R 19 , Ci-Cβ alkyl substituted with a 5-10 membered heterocyclic ring system having 1-3 heteroatoms selected independently from 0, S, and N, said heterocyclic ring being substituted with 0-4 R 19 ; R 18b is selected from R 18a or H; R 19 is selected from H, halogen, CF 3 , CN, N0 2 , NR 12 R 13 , Cι~ Cβ alkyl, C 2 -C6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 11 cycloalkyl, C 4 -C 11 cycloalkylalkyl, aryl, aryKCi-Cβ alkyl)-, Ci-Cβ alkoxy, or C 1 -C 4 alkoxycarbonyl; provided that n, q and r are chosen such that the number of atoms connecting R 1 and Y is in the range of 8-18, [7] Preferred compounds of this second embodiment are those compounds of Formula la: wherein: Z is selected from a bond (i.e. is absent), 0, or S; and/or R 2 is selected from H, aryl(Cι-Cιo alkoxy)carbonyl, or Ci-Cio alkoxycarbonyl; and/or W is -(CH 2 ) n C(=0)N(R 5a )-; and/or X is -(C(R 4 ) 2 ) n -C(R 4 ) (R 8 )-CH(R 4 )-, with the proviso that when n is 0 or 1, then at least one of R a or R 8 is other than H or methyl; and/or R 5 is selected from H or Ci-Cio alkyl substituted with 0-6 R 4b ; and/or R 6 is selected from H, Ci-Cio alkyl, hydroxy, Ci-Cio alkoxy, nitro, Ci-Cio alkylcarbonyl, -N(R 12 )R 13 , -NR 5 R 5 , C0 2 R 5 , S(0) m R 5 , OR 5 , cyano, halo; Cβ to Cio aryl optionally substituted with 1-3 groups selected from halogen, Ci-Cβ alkoxy, Cι~C 6 alkyl, CF3, S(0) m Me, or -NMe 2 ; C 7 to Cn arylalkyl, said aryl being optionally substituted with 1-3 groups selected from halogen, Ci-C δ alkoxy, Ci-Cβ alkyl, CF3, S(0)mMe, or -NMe 2 ; methylenedioxy when R 6 is a substituent on aryl; or a 5-10 membered heterocyclic ring containing 1-3 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 7 ; and/or R 7 is selected from selected from H, Ci-Cio alkyl, hydroxy, Ci-Cio alkoxy, nitro, Ci-Cio alkylcarbonyl, -N(R 12 )R 13 , cyano, or halo; and/or R 8 is selected from: -CONR 5 NR 5 ; -C0 2 R 5 ; Ci-Cio alkyl, substituted with 0-3 R 6 ; C 2 -C 1 0 alkenyl, substituted with 0-3 R 6 ; C 2 -C 1 0 alkynyl, substituted with 0-3 R 6 , C3-C8 cycloalkyl, substituted with 0-3 R 6 ; C5-C6 cycloalkenyl, substituted with 0-3 R 6 ; aryl, substituted with 0-2 R 6 ; 5-10 membered heterocyclic ring containing 1-3 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 6 ; and/or R 12 and R 13 are each independently selected from H, C 1 -C 1 0 alkyl, C 1 -C 10 alkoxycarbonyl, C 1 -C 1 0 alkylcarbonyl, C 1 -C 1 0 alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, arylsulfonyl, aryl, heteroarylcarbonyl, or heteroarylalkylcarbonyl, wherein said aryls are optionally substituted with 0-3 substituents selected from the group consisting of: C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , and N0 2 . [8] Further preferred compounds of this second embodiment are those compounds of Formula la: wherein: Z is selected from a bond (i.e. is absent) or O; and/or W is -(CH 2 ) n C(=0)N(R 12 )-; and/or X is -C(R 4 ) (R 8 )-C(R 4 ) 2 -. [9] Further preferred compounds of this second embodiment are compounds of Formula la, wherein: R 1 is R 2 NHC(=NR 2 )-, R 2 NHC(=NR 2 )NH- and V is phenylene or pyridylene, or R 1 is and V is a single bond (i.e. V is absent) ; n is 1 or 2; X is -CHR 8 CH 2 -; Y is selected from: hydroxy; Ci to Cio alkoxy; methylcarbonyloxymethoxy-; ethylcarbonyloxymethoxy-; t-butylcarbonyloxymethoxy-; cyclohexylcarbonyloxymethoxy-; 1- (methylcarbonyloxy) ethoxy-; 1- (ethylcarbonyloxy) ethoxy-; 1- (t-butylcarbonyloxy) ethoxy-; 1- (cyclohexylcarbonyloxy) ethoxy-; i-propyloxycarbonyloxymethoxy-; t-butyloxycarbonyloxymethoxy-; 1- (i-propyloxycarbonyloxy) ethoxy-; 1- (cyclohexyloxycarbonyloxy) ethoxy-; 1- ( t-butyloxycarbonyloxy) ethoxy-; dimethylaminoethoxy-; diethylaminoethoxy-; (5-methyl-l,3-dioxacyclopenten-2-on-4-yl)methoxy-; (5- (t-butyl) -l,3-dioxacyclopenten-2-on-4-yl)methoxy-; (1,3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methoxy-; 1- (2- (2-methoxypropyl) carbonyloxy) ethoxy-; R 6 is selected from H, C 1 -C 4 alkyl, hydroxy, C 1 -C 4 alkoxy, nitro, C 1 -C 10 alkylcarbonyl, -N(R 12 )R 13 , -NR 5 R 5 , CO2R 5 , S(0) m R 5 , OR 5 , cyano, halo; Cβ to Cio aryl optionally substituted with 1-3 groups selected from halogen, Ci-Cβ alkoxy, C 1 -C 6 alkyl, CF 3 , S(0)mMe, or -NMe 2 ; methylenedioxy when R 6 is a substituent on aryl; or a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, - pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, isoxazolinyl or morpholinyl; R 8 is selected from: -CONR 5 NR 5a ; -C0 2 R 5 ; C 1 -C 10 alkyl, substituted with 0-3 R 6 ; C 2 -C 10 alkenyl, substituted with 0-3 R 6 ; C2-C10 alkynyl, substituted with 0-3 R 6 , C 3 -C 8 cycloalkyl, substituted with 0-3 R 6 ; aryl, substituted with 0-2 R 6 ; a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, isoxazolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-2 R 6 ; R 12 is selected from H, Ci-C δ alkyl, C 1 -C 4 alkoxycarbonyl, C1-C 6 alkylcarbonyl, C 1 -C 6 alkylsulfonyl, aryl (C 1 -C 4 alkyl)sulfonyl, arylsulfonyl, aryl, pyridylcarbonyl or pyridylmethylcarbonyl, wherein said aryls are optionally substituted with 0-3 substituents selected from the group consisting of: C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , and N0 2 ; and R 13 is H. [10] , [35] Specifically preferred compounds of this second embodiment are compounds, or enantiomeric or diasteriomeric forms thereof, or mixtures of enantiomeric or diasteriomeric forms thereof,, or a pharmaceutically acceptable salt or prodrug forms thereof, selected from: 3 (R, S)-{5 (R, S)-N-[3-(4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-3-phenylpropanoic acid; 3 (R, S)-{5 (R, S)-N-[3-(4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-pentanoic acid; 3 (R) -{5 (R, S) -N-[3-(4-amidinophenyl)isoxazolin-5- ylacetyl]amino}heptanoic acid; 3 (R, S)-{5 (R, S) -N- [3 -(4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-4-(phenylthioJbutanoic acid; 3 (R, S)-{5 (R, S) -N- [3 -(4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-4-(phenylsulfonamido)butanoic acid; 3 (R, S)-{5 (R, S) -N- [3 - (4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-4-(n-butylsulfonamido)butanoic acid; 3 ( S) -{5 (R, S)-N-[3-(4-amidinophenyl)isoxazolin-5- ylacety1]amino}-3- (adamantylmethylaminocarbonyl)propanoic acid; 3 ( S) -{5 (R, S)-N-[3-(4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-3-(1- azabicyclo[3.2.2]nonylcarbony1)propanoic acid; 3 ( S) -{5 (R, S)-N-[3- (4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-3-(phenethylaminocarbonyl)propanoic acid; 3 (R)-{5 (R, S)-N-[3- (4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-3- (3-pyridylethyl)propanoic acid; 3 (R) -{5 (R, S)-N-[3-(4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-3-(2-pyridylethyl)propanoic acid; 3 (R) -{5 (R, S)-N-[3-(4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-3-(phenylpropyl)propanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl] -N 2 - (phenylsulfonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl]-N 2 - (4-methyl-phenyl-sulfonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinopheny1)-isoxazolin-5-yl}-acetyl]-N 2 - (butanesulfonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinopheny1) -isoxazolin-5-yl}-acetyl] -N 2 - (propanesulfonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (ethanesulfonyl)-2,3-diaminopropanoic acid; N 3 -[2-(3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl] -N 2 - (methyloxycarbonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl]-N 2 - (ethyloxycarbonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl]-N 2 - (1-propyloxycarbony1)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinopheny1)-isoxazolin-5-yl}-acetyl]-N 2 - (2-propyloxycarbonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinopheny1)-isoxazolin-5-yl}-acetyl]-N 2 - (n-butyloxycarbonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (1-(2-methyl)-propyloxycarbony1)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinopheny1) -isoxazolin-5-yl}-acetyl] -N 2 - (2-(2-methyl)-propyloxycarbony1)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (benzyloxycarbonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinopheny1) -isoxazolin-5-yl}-acetyl] -N 2 - (4-methylbenzyloxycarbony1)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl] -N 2 - (4-methoxybenzyloxycarbonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl]-N 2 - (4-chlorobenzyloxycarbony1) -2,3-diaminopropanoic acid; N 3_[2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (4-bromobenzyloxycarbonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl]-N 2 - (4-fluorobenzyloxycarbonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl]-N 2 - (4-phenoxybenzyloxycarbony1)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl]-N 2 - (2-(methyloxyethy1)-oxycarbonyl)-2,3-diaminopropanoic acid; N 3 - [2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (2-pyridinylcarbonyl)-2,3-diaminopropanoic acid; N 3 - [2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl]-N 2 - (3-pyridinylcarbonyl)-2,3-diaminopropanoic acid; N 3. [2-{3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl]-N 2 - (4-pyridinyl-carbonyl)-2,3-diaminopropanoic acid; N 3. [2-{3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl]-N 2 - (2-(2-pyridinyl)-acetyl)-2,3-diaminopropanoic acid; N 3. [2-{3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl]-N 2 - (2-(3-pyridinyl)-acetyl)-2,3-diaminopropanoic acid; N 3. [2-{3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl] -N 2 - (2-(4-pyridinyl)-acetyl)-2,3-diaminopropanoic acid; N 3 - [2-{3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl]-N 2 - (2-pyridyl-methyloxycarbonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (3-pyridyl-methyloxycarbonyl) -2,3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (4-pyridyl-methyloxycarbonyl) -2, 3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinopheny1) -isoxazolin-5-yl}-acetyl] -N 2 - (4-butyloxyphenylsulfonyl) -2, 3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (2-thienylsulfonyl) -2,3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (3-methylphenylsulfonyl) -2,3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinopheny1) -isoxazolin-5-yl}-acetyl] -N 2 - (4-iodophenylsulfonyl) -2,3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (3-trifluoromethylphenylsulfonyl) -2,3- diaminopropanoic acid; N 3 -[2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (3-chlorophenylsulfonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (3-2-methoxycarbonylphenylsulfonyl) -2,3- diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (2,4, 6-trimethylphenylsulfonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (2-chlorophenylsulfonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (4-trifluoromethylphenylsulfonyl) -2,3- diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (2-trifluoromethylphenylsulfonyl) -2,3- diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (2-fluorophenylsulfonyl) -2,3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (4-fluorophenylsulfonyl) -2,3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (4-methoxyphenylsulfonyl) -2,3-diaminopropanoic acid; [2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl]-N 2 - (2,3,5,6-tetramethylphenylsulfonyl)-2,3- diaminopropanoic acid; [2-{3- (4-formamidinophenyl)-isoxazolin-5-yl}-acetyl]-N 2 - (4-cyanophenylsulfonyl) -2,3-diaminopropanoic acid; [2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (4-chlorophenylsulfonyl)-2,3-diaminopropanoic acid; [2-{3-(4-formamidinopheny1) -isoxazolin-5-yl}-acetyl] -N 2 - (4-propylphenylsulfonyl)-2,3-diaminopropanoic acid; [2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl]-N 2 - (2-phenylethylsulfonyl) -2,3-diaminopropanoic acid; [2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (4-isopropylphenylsulfonyl)-2,3-diaminopropanoic acid; [2-{3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl]-N 2 - (3-phenylpropylsulfonyl)-2,3-diaminopropanoic acid; [2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl]-N 2 - (3-pyridylsulfonyl)-2,3-diaminopropanoic acid; [2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl]-N 2 - (phenylaminosulfonyl)-2,3-diaminopropanoic acid; [2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl]-N 2 - (benzylaminosulfonyl)-2,3-diaminopropanoic acid; [2-{3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl]-N 2 - (dimethylaminosulfonyl)-2,3-diaminopropanoic acid; [2-{3-(2-fluoro-4-formamidinophenyl)-isoxazolin-5-yl}- acetyl]-N 2 - (3-methylphenylsulfonyl) -2,3- diaminopropanoic acid; [2-{3-(2-formamidino-5-pyridinyl)-isoxazolin-5-yl}- acetyl]-N 2 - (n-butyloxycarbonyl)-2,3-diaminopropanoic acid; [2-{3-(2-formamidino-5-pyridinyl)-isoxazolin-5-yl}- acetyl]-N 2 - (3-methylphenylsulfonyl) -2,3- diaminopropanoic acid; [2-{3-(3-formamidino-6-pyridinyl)-isoxazolin-5-yl}- acetyl]-N 2 - (n-butyloxycarbonyl)-2,3-diaminopropanoic acid; N 3 - [2-{3- (3-formamidino-6-pyridinyl) -isoxazolin-5-yl}- acetyl] -N 2 - (3-methylphenylsulfonyl) -2,3- diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (phenylaminocarbonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (4-fluorophenylaminocarbonyl) -2,3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (1-naphthylaminocarbonyl) -2,3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (benzylaminocarbonyl) -2,3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinopheny1) -isoxazolin-5-yl}-acetyl] -N 2 - (3-bromo-2-thienylsulfonyl) -2,3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (3-methyl-2-benzothienylsulfonyl) - ~ 2,3- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (isobutyloxycarbonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (isobutyloxycarbonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (isobutyloxycarbonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (2-cyclopropylethoxycarbonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3- (4-guanidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (n-butyloxycarbonyl)-2,3-diaminopropanoic acid; N 3 - [2-{3- (4-guanidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (3-methylphenylsulfonyl) -2,3-diaminopropanoic acid; N 3 - [2-{5- (4-formamidinopheny1) -isoxazolin-3-yl}-acetyl] -N 2 - (n-butyloxycarbonyl) -2, 3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (2-bromo-phenylsulfonyl) -2,3-diaminopropionic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] -N 2 - (2-methyl-phenylsulfonyl)-2,3-diaminopropionic acid; N 3 -[2-{3-(3-formamidino-6-pyridinyl)-isoxazolin-5-yl}- acetyl]-N 2 - (3-methylphenylsulfonyl) -2,3- diaminopropionic acid; N 3 -[2-{3-(2-formamidino-5-pyridinyl)-isoxazolin-5-yl}- acetyl]-N 2 - (3-methylphenylsulfonyl) -2,3- diaminopropionic acid; N 3 -[2-{3-(2-fluoro-4-formamidinophenyl)-isoxazolin-5-yl}- acetyl]-N 2 - (3-methylphenylsulfonyl) -2,3- diaminopropionic acid; N 3 -[2-{3- (4-formamidinophenyl)-isoxazolin-5-yl}-acetyl]-N 2 - (3-bromo-phenylsulfonyl)-2,3-diaminopropionic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl] -N 2 - (4-bromo-phenylsulfonyl)-2,3-diaminopropionic acid; said enantiomeric and diasteriomeric forms being selected from: ( R , S) , ( R , S) ; The prodrug forms of the compounds of the second embodiment include the following esters: methyl; ethyl; isopropyl; methylcarbonyloxymethyl-; ethylcarbonyloxymethyl-; t-butylcarbonyloxymethyl-; cyclohexylcarbonyloxymethyl-; 1- (methylcarbonyloxy)ethyl-; 1- (ethylcarbonyloxy) ethyl-; 1- (t-butylcarbonyloxy) ethyl-; 1- (cyclohexylcarbonyloxy) ethyl-; i-propyloxycarbonyloxymethyl-; cyclohexylcarbonyloxymethyl-; t-butyloxycarbonyloxymethyl-; 1- (i-propyloxycarbonyloxy) ethyl-; 1- (cyclohexyloxycarbonyloxy) ethyl-; 1- (t-butyloxycarbonyloxy) ethyl-; dimethylaminoethyl-; diethylaminoethyl-; (5-methyl-l,3-dioxacyclopenten-2-on-4-yl)methyl-; (5- (t-butyl) -1, 3-dioxacyclopenten-2-on-4-yl)methyl-; (1,3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methyl-; 1- (2- (2-methoxypropyl) carbonyloxy) ethyl- . [11] Also preferred compounds of the second embodiment are those compounds of Formula Ic: (ic) wherein: b is a single or double bond; R 1 is selected from R 2a (R 3 )N-, R 2 (R 3 )N(R 2 N=)C-, R 2a (R 3 )N(CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)C (CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)CN(R 2 )-, R 2 (R 3 )NC (O) -, R 2 (R 5 0)N(R 2 N=)C- or R 2 (R 3 )N(R 5 ON=)C-; Z is selected from a bond (i.e. is absent), 0, or S; R 2 and R 3 are independently selected from: H; Ci-Cβ alkyl; C 7 -C 11 arylalkyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cβ alkoxy, Ci-Cβ alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 1 -C 10 alkoxycarbonyl; aryl(Cι-Cιo alkoxy)carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cε alkoxy, C -C6 alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; or heteroaryl(C 1 -C 5 )alkyl where the heteroaryl group is optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-Cβ alkoxy, Ci-Cβ alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; R 2a is R 2 or R2 (R 3) N(R 2 N=)C . U is a single bond (i.e., U is not present), V is selected from: a single bond (i.e., V is not present); -(C 1 -C 7 alkyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(C 2 -C 7 alkenyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; - (C 2 -C 7 alkynyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(phenyl)-Q-, said phenyl substituted with 0-2 groups independently selected from R 6 or R 7 ; -(pyridyl)-Q-, said pyridyl substituted with 0-2 groups independently selected from R 6 or R 7 ; or - (pyridazinyl) -Q-, said pyridazinyl substituted with 0-2 groups independently selected from R 6 or R 7 ' Q is selected from a single bond (i.e., Q is not present), -0-, -S(0) m -, -N(R 12 )-, -(CH 2 ) m -, -C(=0)-, -N(R 5 )C(=0)-, -C(=0)N(R 5a )-, -CH 2 0-, -OCH 2 -, -CH 2 N(R 12 )-, -N(R 12 )CH 2 -, -CH 2 C(=0)-, -C(=0)CH 2 -, -CH 2 S(0) m -, or -S(0) m CH 2 -, provided that when b is a single bond, and R 1 -U-V- is a substituent on C5 of the central 5-membered ring in Formula I, then Q is not -0-, -S(0) m -, -N(R 12 )-, -C(=0)N(R 5 )-, -CH 2 0-, CH 2 N(R 12 )- or -CH 2 S(0) m -; W is selected from: -(C(R 4 ) 2 )-C(=0)-N(R 5a )-, or -C(=0)-N(R 5a )-(C(R ) 2 )-; X is -C(R 4 ) 2 -CHR a -; R 4 is selected from H, Ci-Cio alkyl, Ci-Cio alkylcarbonyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; R a is selected from hydroxy, Ci-Cio alkoxy, nitro, -N(R 5 )R 5 , -N(R 12 )R 13 , or -N(R 16 )R 17 , Ci-Cio alkyl substituted with 0-3 R 6 , aryl substituted with 0-3 R 6 , heteroaryl substituted with 0-3 R 6 , or Ci-Cio alkylcarbonyl; R 4b is selected from H, Ci-C δ alkyl, C2-C 6 alkenyl, C 2 -C 6 alkynyl, hydroxy, Ci-Cβ alkoxy, Ci-Cβ alkylthio, C 1 -C 6 alkylsulfinyl, Ci-Cg alkylsulfonyl, nitro, C 1 -C 6 alkylcarbonyl, C 6 -C 10 aryl, -N(R 12 )R 13 , halo, CF 3/ CN, Ci-Cβ alkoxycarbonyl, carboxy, piperidinyl, morpholinyl or pyridyl; R 5 is selected from H or C 1 -C 10 alkyl substituted with 0-6 R 4b ; R 5a is selected from hydrogen, hydroxy, Ci to Cs alkyl, C 2 to Cβ alkenyl, C 3 to Cn cycloalkyl, C4 to Cn cycloalkylmethyl, Ci-Cβ alkoxy, benzyloxy, β to Cio aryl, heteroaryl, heteroarylalkyl, C 7 to Cn arylalkyl, or adamantylmethyl, C1-C 10 alkyl substituted with 0-2 R 4b ; alternately, R 5 and R 5 can be taken together to be 3- azabicyclononyl, 1,2,3, 4-tetrahydro-l-quinolinyl, l,2,3,4-tetrahydro-2-isoquinolinyl, 1-piperidinyl, 1- morpholinyl, 1-pyrrolidinyl, thiamorpholinyl, thiazolidinyl or 1-piperazinyl, each being optionally substituted with Ci-Cβ alkyl, Cβ-Cio aryl, heteroaryl, C7-C 11 arylalkyl, C 1 -C 6 alkylcarbonyl, C 3 -C 7 cycloalkylcarbonyl, C 1 -C 6 alkoxycarbonyl or C 7 -C 11 arylalkoxycarbonyl; R 5b is selected from Ci-Cs alkyl, C 2 -C 6 alkenyl, C 3 -C 11 cycloalkyl, C 4 -C1 1 cycloalkylmethyl, C 6 -C 10 aryl, C7- C1 1 arylalkyl, or C1-C1 0 alkyl substituted with 0-2 R 4b Y is selected from hydroxy, Ci to Cio alkyloxy, C3 to C 1 1 cycloalkyloxy, Cβ to Cio aryloxy, C7 to Cn aralkyloxy, C 3 to Cio alkylcarbonyloxyalkyloxy, C 3 to Cio alkoxycarbonyloxyalkyloxy, C 2 to Cio alkoxycarbonylalkyloxy, C5 to Cio cycloalkylcarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonyloxyalkyloxy, C5 to Cio cycloalkoxycarbonylalkyloxy, C7 to Cn aryloxycarbonylalkyloxy, Cs to Cι 2 aryloxycarbonyloxyalkyloxy, Cs to Cι 2 arylcarbonyloxyalkyloxy, C5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C5 to Cio (5-alkyl- 1,3-dioxa-cyclopenten-2-one-yl)methyloxy, or Cio to C14 (5-aryl-l,3-dioxa-cyclόpenten-2-one-yl)methyloxy; R 6 and R 7 are each independently selected from H, C 1 -C 10 alkyl, hydroxy, C 1 -C 10 alkoxy, nitro, C 1 -C 10 alkylcarbonyl, -N(R 12 )R 13 , cyano, or halo; R 12 and R 13 are each independently selected from H, C 1 -C 10 alkyl, C1-C10 alkoxycarbonyl, C 1 -C 10 alkylcarbonyl, Ci-Cio alkylsulfonyl, aryl(Cι-Cιo alkyl) sulfonyl, arylsulfonyl, heteroarylcarbonyl, heteroarylalkylcarbonyl or aryl, wherein said aryls are optionally substituted with 0-3 substituents selected from the group consisting of: C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , and N0 2 ; R 15 is selected from H, C 1 -C 1 0 alkyl, C 2 -Cιo alkenyl, C 2 - C 1 0 alkynyl, C1-C 10 alkoxy, aryl, heteroaryl or C 1 -C 10 alkoxycarbonyl, CO 2 R 5 or -C(=0)N(R 5 )R 5 ; R 16 is selected from: -C(=0)-0-R 18a , -C(=0)-R 18b , -C(=0)N(R 18b ) 2 , -S0 2 -R 18a , or -S0 2 -N ( R 18b) 2 ; R 17 is selected from: H or C 1 -C 4 alkyl; 18a i s selected from: Ci-Cs alkyl substituted with 0-2 R 19 , C 2 -C 8 alkenyl substituted with 0-2 R 19 , C -Cs alkynyl substituted with 0-2 R 19 , C 3 -C 8 cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-4 R 19 , aryl (Ci-Ce alkyl)- substituted with 0-4 R 19 , a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, isoxazolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyrimidinyl, 3H-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-4 R l9 ; C 1 -C 6 alkyl substituted with a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolinyl, benzofuranyl, indolyl, indolenyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, indolyl, carbazole, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-4 R 19 ; 18b i s selected from R 18 or H; R 19 is selected from H, halogen, CF3, CN, NO 2 , NR 12 R 13 , Ci- Cs alkyl, C 2 -C 6 alkenyl, C2-C6 alkynyl, Cι~C alkoxy, C 3 -C 11 cycloalkyl, C 4 -C 11 cycloalkylalkyl, aryl, heteroaryl, aryl (Ci-Cβ alkyl)-, or C 1 -C 4 — alkoxycarbonyl; n is 0-4; q is 1-7, r is 0-3, provided that n, q, and r are chosen such that the number of atoms between R 1 and Y is in the range of 8-17. [12] Further preferred compounds of the second embodiment of Formula Ic are those compounds of Formula lb: (lb) wherein: R 1 is selected from: R 2 <R 3 )N-, R 2 NH(R 2 N=)C-, R 2 NH(R 2 N=)CNH-, R 2 R 3 N(CH 2 ) p -Z-, R 2 NH(R 2 N=)CNH(CH 2 ) P »Z-, R 2 (R 3 )NC(0)-, R 2 (R 5 0)N(R 2 N=)C-, or R 2 (R 3 )N(R 5 ON=)C-; / n is 0-1; p' is 4-6; _ p" is 2-4; Z is selected from a bond (i.e. is absent) or 0; V is a single bond (i.e., V is not present), -(phenyl)- or -(pyridyl)-; W is selected from: -(C(R 4 ) 2 )-C(=0)-N(R 5a )-, -C(=0)-N(R 5 )-CH 2 -; X is selected from: -CH 2 -CHN(R 16 )R 17 -, or -CH 2 -CHNR 5 R 5a -; Y is selected from: hydroxy; Ci to Cio alkoxy; methylcarbonyloxymethoxy-; ethylcarbonyloxymethoxy-; t-butylcarbonyloxymethoxy-; cyclohexylcarbonyloxymethoxy-; 1-(methylcarbonyloxy)ethoxy-; 1-(ethylcarbonyloxy)ethoxy-; 1-(t-butylcarbonyloxy)ethoxy-; 1-(eyelohexylcarbonyloxy)ethoxy-; i-propyloxycarbonyloxymethoxy-; t-butyloxycarbonyloxymethoxy-; 1-(i-propyloxycarbonyloxy)ethoxy-; 1- (cyclohexyloxycarbonyloxy)ethoxy-; 1-(t-butyloxycarbonyloxy)ethoxy-; dimethylaminoethoxy-; diethylaminoethoxy-; (5-methyl-l,3-dioxacyclopenten-2-on-4-yl)methoxy-; (5-(t-butyl)-1,3-dioxacyclopenten-2-on-4-yl)methoxy-; (1,3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methoxy-; 1-(2-(2-methoxypropyl)carbonyloxy)ethoxy-; R 16 is selected from: -C(=0)-0-R 18 , -C(=0)-R 18b , -S(=0) 2 -R 18 or -S0 2 -N ( R 18b) ; R 17 is selected from H or C 1 -C 5 alkyl; R i8a i s selected from: Ci-Cs alkyl substituted with 0-2 R 19 , C 2 -C 8 alkenyl substituted with 0-2 R 19 , C 2 -Cs alkynyl substituted with 0-2 R 19 , C3-C8 cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-4 R 19 , aryl(Cι-C6 alkyl)- substituted with 0-4 R 19 , a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, isoxazolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyrimidinyl, 3H-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-4 R 19 ; C 1 -C 6 alkyl substituted with a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolinyl, benzofuranyl, indolyl, indolenyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, indolyl, carbazole, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-4 R 19 . [13] Further preferred compounds of Formula lb are those compounds wherein: R 1 is R 2 NH(R 2 N=)C- or R 2 HN(R 2 N=)CNH- and V is phenylene or pyridylene; or R 1 is and V is a single bond (i.e. V is absent) ; n is 1 or 2; i8a is selected from: C 1 -C 4 alkyl substituted with 0-2 R 19 , C 2 -C 4 alkenyl substituted with 0-2 R 19 , C 2 -C4 alkynyl substituted with 0-2 R 19 , C3-C7 cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-4 R 19 , aryl(Cι-C alkyl)- substituted with 0-4 R 19 , a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, isoxazolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyrimidinyl, 3H-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, isoxazolinyl or morpholinyl, said heterocyclic ring being substituted with 0-4 R 19 ; C 1 -C 4 alkyl substituted with a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolinyl, benzofuranyl, indolyl, indolenyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, indolyl, carbazole, pyrrolidinyl, piperidinyl, indolinyl, isoxazolinyl or morpholinyl, said heterocyclic ring being substituted with 0-4 R l9 . [14] Specifically preferred compounds of Formula lb are compounds, or pharmaceutically acceptable salt forms thereof, selected from: N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -γl} - acetyl]-N2- (phenylsulfonyl)-2,3-(S)-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (4-methyl-phenyl-sulfonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S ) -yl} ~ acetyl]-N2- (butanesulfonyl)-2,3-(S)-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (propanesulfonyl)-2,3- (S) -diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl) - . acetyl]-N2- (ethanesulfonyl)-2,3- (S)-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(methyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl ) ~ acetyl]-N2-(ethyloxycarbonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} - acetyl]-N2-(1-propyloxycarbony1)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinopheny1)-isoxazolin-5 (R, S)-yl}- acetyl]-N2-(2-propyloxycarbony1)-2,3- (S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl } ~ acetyl]-N2-(n-butyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinopheny1)-isoxazolin-5 (R) -yl} - acetyl]-N2-(n-butyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5(S7-yl}- acetyl]-N2-(n-butyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5(J?^-yl}- acetyl]-N2- (n-butyloxycarbonyl)-2,3-(R)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (S) -yl} - acetyl]-N2-(n-butyloxycarbonyl)-2,3-(R)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} - acetyl]-N2-(2-butyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S)-yl}- acetyl]-N2-(1-(2-methyl)-propyloxycarbonyl)-2,3-(S) diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (2-(2-methyl)-propyloxycarbonyl)-2,3- (S) diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(benzyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R) -yl} - acetyl]-N2-(benzyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-(3-(4-formamidinophenyl)-isoxazolin-5 (S) -yl} - acetyl]-N2-(benzyloxycarbonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}- acetyl]-N2- (4-methylbenzyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}~ acetyl]-N2- (4-methoxybenzyloxycarbony1)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}~ acetyl]-N2- (4-chlorobenzyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}- acetyl]-N2- (4-bromobenzyloxycarbony1)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}~ acetyl]-N2- (4-fluorobenzyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}~ acetyl]-N2- (4-phenoxybenzyloxycarbonyl) -2, 3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S )-yl}- acetyl]-N2- (2-(methyloxyethyl)-oxycarbonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S) -yl}- acetyl]-N2-(2-pyridinylcarbony1)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}~ acetyl]-N2- (3-pyridinylcarbony1)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}~ acetyl]-N2-(4-pyridinyl-carbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}~ acetyl]-N2- (2-(2-pyridinyl)-acetyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}~ acetyl]-N2- (2-(3-pyridinyl)-acetyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S ) -yl} - acetyl]-N2- (2-(4-pyridinyl)-acetyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (2-pyridyl-methyloxycarbonyl)-2,3- (S) diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5(£,.?,)-yl¬ acetyl]-N2- (3-pyridyl-methyloxycarbonyl)-2,3-(S) diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} - acetyl]-N2- (4-pyridyl-methyloxycarbonyl)-2,3- (S) diaminopropanoic acid. N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} - acetyl]-N2-(4-butyloxyphenylsulfonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl } ~ acetyl]-N2-(2-thienylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (3-methylphenylsulfonyl)-2,3-(R,S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S ) -yl} - acetyl]-N2-(3-methylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(3-methylphenylsulfonyl)-2,3-(R)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R)-yl}- acetyl]-N2- (3-methylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5(s -yl}- acety1]-N2- (3-methylphenylsulfony1)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (S) -yl} - acetyl]-N2- (3-methylphenylsulfony1)-2,3-(R)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R) -yl} - acetyl]-N2- (3-methylphenylsulfonyl)-2,3-(R)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(4-iodophenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (3-trifluoromethylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (3-chlorophenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (3-2-methoxycarbonylphenylsulfonyl)-2,3- (S)-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (2,4,6-trimethylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (2-chlorophenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (4-trifluoromethylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (2-trifluoromethylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (2-fluorophenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (4-fluorophenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl) - acetyl]-N2- (4-methoxyphenylsulfonyl) -2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S ) -yl } - acetyl]-N2- (2,3,5,6-tetramethylphenylsulfonyl)-2,3- (S)-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S ) -yl} - acetyl]-N2- (4-cyanophenylsulfonyl)-2,3- (S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (4-chlorophenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (4-propylphenylsulfonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (2-phenylethylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl } ~ acetyl]-N2-(4-isopropylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (3-phenylpropylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5(i?,S^-yl}- acetyl]-N2-(3-pyridylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(phenylaminosulfonyl)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5(i?,S^-yl}- acetyl]-N2-(benzylaminosulfonyl)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (dimethylaminosulfonyl)-2,3-(S) - diaminopropanoic acid, N 3 -[2-{3-(2-fluoro-4-formamidinophenyl)-isoxazolin-5 (R, S) - yl}-acetyl] -N2- (3-methylphenylsulfonyl) -2,3-(S)- diaminopropanoic acid, N 3 -[2-{3- (2-formamidino-5-pyridinyl) -isoxazolin-5 (R, S) - yl}-acetyl] -N2- (n-butyloxycarbonyl)-2,3- (S)- diaminopropanoic acid, N 3 -[2-{3-(2-formamidino-5-pyridinyl) -isoxazolin-5 (R, S) - yl}-acetyl]-N2-(3-methylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid, N 3 -[2-{3-(3-formamidino-6-pyridinyl)-isoxazolin-5 (R, S) - yl}-acetyl] -N2-(n-butyloxycarbonyl)-2,3-(S)- diaminopropanoic acid, N 3 -[2-{3-(3-formamidino-6-pyridinyl) -isoxazolin-5 (R, S) - yl}-acetyl]-N2-(3-methylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid, N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} - acetyl]-N2- (phenylaminocarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} - acetyl]-N2-(4-fluorophenylaminocarbonyl)-2,3-(S) - diaminopropanoic acid; N 3 -J2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (1-naphthylaminocarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(benzylaminocarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (3-bromo-2-thienylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (3-methyl-2-benzothienylsulfonyl)-2,3-(S)- diaminopropanoic acid, N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} - acetyl]-N2- (isobutyloxycarbonyl)-2,3-(S) - diaminopropanoic acid, N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R) -yl} - acetyl]-N2-(isobutyloxycarbonyl)-2,3-(S) - diaminopropanoic acid, N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5(≤ -yl¬ acetyl]-N2-(isobutyloxycarbonyl)-2,3- (S)- diaminopropanoic acid, N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} - acetyl]-N2- (2-cyclopropylethoxycarbonyl)-2,3-(S) - diaminopropanoic acid, N 3 -[2-{3- (4-formamidinophenyl)-isoxazolin-5(f?J-yl}- acetyl]-N2- (2-cyclopropylethoxycarbonyl)-2,3-(S) - diaminopropanoic acid, and N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (S) -yl} - acetyl]-N2- (2-cyclopropylethoxycarbonyl)-2,3-(S)- diaminopropanoic acid. N 3 -[2-{3-(4-guanidinophenyl)-isoxazolin-5 (R, S ) -yl} - acetyl]-N2-(n-butyloxycarbonyl)-2,3- (S)- diaminopropanoic acid. N 3 -[2-{3-(4-guanidinophenyl)-isoxazolin-5 (i?J-yl}-acetyl]- N2-(n-butyloxycarbonyl)-2,3- (S)-diaminopropanoic acid. N 3 -[2-{3-(4-guanidinophenyl)-isoxazolin-5 (R) -yl )-acetyl]- N2-(3-methylphenylsulfonyl)-2,3-(S)-diaminopropanoic acid. N 3 -[2-{5-(4-formamidinophenyl)-isoxazolin-3 (R, S) -yl} ~ acetyl]-N2- (n-butyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; [15] Also specifically preferred are prodrug esters of the specifically preferred compounds of Formula lb, said esters being chosen from the group consisting of: methyl; ethyl; isopropyl; methylcarbonyloxymethyl-; ethylcarbonyloxymethyl-; t-butylcarbonyloxymethyl-; cyclohexylcarbonyloxymethyl-; 1-(methylcarbonyloxy)ethyl-; 1-(ethylcarbonyloxy)ethyl-; 1-(t-butylcarbonyloxy)ethyl-; 1-(cyclohexylcarbonyloxy)ethyl-; i-propyloxycarbonyloxymethyl-; cyclohexylcarbonyloxymethyl-; t-butyloxycarbonyloxymethyl-; 1-(i-propyloxycarbonyloxy)ethyl-; 1-(cyclohexyloxycarbonyloxy)ethyl-; 1-(t-butyloxycarbonyloxy)ethyl-; dimethylaminoethyl-; diethylaminoethyl-; (5-methyl-l,3-dioxacyclopenten-2-on-4-yl)methyl-; (5-(t-butyl)-1,3-dioxacyclopenten-2-on-4-yl)methyl-; (1,3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methyl-; 1-(2-(2-methoxypropyl)carbonyloxy)ethyl-. [16] A third embodiment of this invention provides a compound of Formula Id: or a pharmaceutically acceptable salt or prodrug form thereof wherein: R 1 is selected from is selected from R 2 (R 3 )N-, R 2 (R 3 )N(R 2 N=)C-, R 2 (R 3 )N(R 2 N=)CN(R 2 )-, R 2 (R 3 )N(CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)C(CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)CN(R 2 ) (CH 2 ) q Z-, piperazinyl-(CH 2 ) q Z-, R 2 (R 3 )NC(0)-, R 2 (R 5 0)N(R 2 N=)C-, R 2 (R 3 )N(R 5 ON=)C-, Z is selected from a bond (i.e., is absent), 0, S, S(=0), or S ( =0) 2 ; R 2 and R 3 are independently selected from: H; Ci-Cio alkyl; C 3 -C 6 alkenyl; C 3 -C 11 cycloalkyl; C 4 -C 11 cycloalkylalkyl; C 6 -C 10 aryl optionally substituted with 0-3 groups selected from hydroxy, halogen, C 1 -C6 alkoxy, Ci-Cβ alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; , C 7 -C 11 arylalkyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-C δ alkoxy, Ci-Cβ alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 2 -C 7 alkylcarbonyl; C 7 -C 11 arylcarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cε alkoxy, C 1 -C 6 alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 )2» C1-C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 1 -C 10 alkoxycarbonyl; C 4 -C 11 cycloalkoxycarbonyl; C 7 -C 11 bicycloalkoxycarbonyl; C 7 - C1 1 aryloxycarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, alkoxy, Ci-Cβ alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; aryl (C 1 -C1 0 alkoxy) carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, C \ -Cβ alkoxy, Ci-Cβ alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C -Cβ alkylcarbonyloxy(C1-C 4 alkoxy) carbonyl; C 6 -C 10 arylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cβ alkoxy, C 1 -C 6 alkyl, CF 3 , S(0) m CH3, -N(CH 3 ) 2 , C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 4 -C 11 cycloalkylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl; heteroaryl optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-C δ alkoxy, Ci-Cβ alkyl, CF3, S(0)mCH 3 , -N(013) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; or heteroaryl(C 1 -C 5 )alkyl where the heteroaryl group is optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-Cβ alkoxy, Ci-Cβ alkyl, CF3, S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; provided that only one of R 2 and R 3 may be hydroxy; U is selected from: a single bond (i.e., ϋ is absent) — C 1 -C7 alkylene, C 2 -C 7 alkenylene, C 2 -C7 alkynylene, arylene substituted with 0-3 R 6a , , or pyridylene substituted with 0-3 R 6 ; V is selected from: a single bond (i.e., V is absent); C 1 -C7 alkylene substituted with 0-6 R 6 or R 7 ; C 2 -C 7 alkenylene substituted with 0-4 R 6 or R 7 ; C 2 -C 7 alkynylene substituted with 0-4 R 6 or R 7 ; phenylene substituted with 0-4 R 6 or R 7 ; pyridylene substituted with 0-3 R 6 or R 7 ; pyridazinylene substituted with 0-3 R 6 or R 7 ; X is selected from: a single bond (i.e., X is absent); -(CH 2 ) n C(=0)N(R 12 )-; C 1 -C 7 alkylene substituted with 0-6 R 4 , R 8 or R 15 ; C 2 -C 7 alkenylene substituted with 0-4 R 4 , R 8 or R 15 ; C 2 -C 7 alkynylene substituted with 0-4 R 4 , R 8 or R 15 ; Y is selected from: hydrox , Ci to Cio alkyloxy, C 3 to Cn eyeloalkyloxy, C6 to Cio aryloxy, C7 to Cn aralkyloxy, C3 to Cio alkylcarbonyloxyalkyloxy, C3 to Cio alkoxycarbonyloxyalkyloxy, C 2 to Cio alkoxycarbonylalkyloxy, C5 to Cio eyeloalkylcarbonyloxyalkyloxy, C5 to Cio eyeloalkoxycarbonyloxyalkyloxy, C 5 to Cio eyeloalkoxycarbonylalkyloxy, C 7 to Cn aryloxycarbonylalkyloxy, Cβ to C 12 aryloxycarbonyloxyalkyloxy, Cs to C 12 arylcarbonyloxyalkyloxy, C 5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C 5 to Cio (5-alkyl-l,3-dioxa-cyclopenten-2-one- - y 1 ) methy loxy , Cio to C 14 ( 5-aryl-l , 3 -dioxa-cyclopenten-2-one- yD methyloxy; (R 2 ) (R 3 ) N- (Cι-Cιo alkoxy) - ; R 14 and W are attached to the same carbon and taken together to form a spiro-fused, 5-7 membered ring structure of the formula: D, E, F and G are each independently selected from: C(R 6a ) 2 ; carbonyl; a heteroatom moiety selected from N, N(R 12 ), 0, provided that no more than 2 of D, E, F and G are N, N(R 12 ), 0, S, or C(=0) ; alternatively, the bond between D and E, E and F, or F and G in such spiro-fused ring may be a carbon-nitrogen double bond or a carbon-carbon double bond; R 4 is selected from H, Ci-Cio alkyl, hydroxy, Ci-Cio alkoxy, nitro, Ci-Cio alkylcarbonyl, or -N(R 12 )R 13 ; R 6 and R 7 are each independently selected from H, Ci-Cio alkyl, hydroxy, Ci-Cio alkoxy, nitro, Ci-Cio alkylcarbonyl, -N(R 12 )R 13 , cyano, halo, CF 3 , CHO, C0 2 R 5a , C(=0)R 5a , CONHR 5a , CON(R 12 ) 2 , OC(=0)R 5a , OC(=0)OR 5 , OR 5a , 0C(=0)N(R 12 ) 2 , OCH 2 Cθ 2 R 5a , Cθ2CH2C0 2 R 5 , N(R 12 ) 2 , NO2, NR 12 C (=0)R 5a , NR 12 C (=0)0R 5a , NR 12 S0 2 N(R 12 ) 2 , NR 12 S0 2 R 5 , S(0) p R 5a , S0 2 N(R 12 ) 2 , C2 to Cβ alkenyl, C 3 to Cn cycloalkyl, C4 to Cn eyeloalkylmethyl; Cβ to Cio aryl optionally substituted with 1-3 groups selected from halogen, Ci-Cβ alkoxy, Ci-Ce alkyl, CF 3 , S(0)mMe, or -NMe2; C7 to Cn arylalkyl, said aryl being optionally substituted with 1-3 groups selected from halogen, C1-C6 alkoxy, C1-C6 alkyl, CF 3 , S(0)mMe, or -NMe2; methylenedioxy when R 6 is a substituent on aryl; R 6 is selected from C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , NO 2 , or NR 12 R 13 ; R 8 is selected from: H; R 6 ; C 1 -C 10 alkyl, substituted with 0-8 R 6 ; C 2 -C 10 alkenyl, substituted with 0-6 R 6 ; C 2 -C 10 alkynyl, substituted with 0-6 R 6 ; C 3 -C 8 cycloalkyl, substituted with 0-6 R 6 ; C 5 -C 6 cycloalkenyl, substituted with 0-5 R 6 ; aryl, substituted with 0-5 R 6 ; 5-6 membered heterocyclic ring containing 1-2 N, 0, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-5 R 6 ; R 12 and R 13 are independently H, Ci-Cio alkyl, Ci-Cio alkoxycarbonyl, Cι~Cιo alkylcarbonyl, Ci-Cio alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, arylsulfonyl, aryl, C 2 -C 6 alkenyl, C 3 -C 11 cycloalkyl, C4-C11 cycloalkylalkyl, C7-C11 arylalkyl, C2-C7 alkylcarbonyl, C7-C 11 arylcarbonyl, C 2 -Cιo alkoxycarbonyl, C 4 -C11 cycloalkoxycarbonyl, C7-C11 bicycloalkoxycarbonyl, C7-C11 aryloxycarbonyl, heteroarylcarbonyl, heteroarylalkylcarbonyl or aryl (C 1 -C 10 alkoxy) carbonyl, wherein said aryls or heteroaryls are optionally substituted with 0-3 substituents selected from the group consisting of: C1-C 4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , and N0 2 ; R 5 and R 5 are selected independently from H, Ci to Cs alkyl, C 2 to Ce alkenyl, C 3 to Cn cycloalkyl, C4 to Cn cycloalkylmethyl, Cβ to Cio aryl, C7 to Cn arylalkyl, or C 1 -C1 0 alkyl substituted with 0-8 R 4 ; R 15 is selected from: H; R 6 ; C 1 -C 10 alkyl, substituted with 0-8 R 6 ; C2-C 10 alkenyl, substituted with 0-6 R 6 ; C 1 -C 10 alkoxy, substituted with 0-6 R 6 ; aryl, substituted with 0-5 R 6 ; 5-6 membered heterocyclic ring containing 1-2 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-5 R 6 ; Ci-Cio alkoxycarbonyl substituted with 0-8 R 6 ; CO2R 5 ; or -C(=0)N(R 12 )R 13 ; provided that n, p, q and r are chosen such that the number of atoms between R 1 and Y is in the range of 8-17. [47] Also preferred compounds of the second embodiment are those compounds of Formulae le or If: (If) or enantiomeric or diasteriomeric forms thereof, or mixtures of enantiomeric or diasteriomeric forms thereof, or a pharmaceutically acceptable salt form thereof, wherein: R 1 is R 2 (R 3 )N(R 2 N=)C-, R 2 (R 3 )N(R 2 N=)CN(R 2 ) -, or R 2 (R 3 )N-; R 2 and R 3 are independently selected from: H; C1-C 10 alkyl; C 3 -C 6 alkenyl; C 3 -C 11 cycloalkyl; C 4 -C 11 cycloalkylalkyl; C 6 -C 10 aryl optionally substituted with 0-3 groups selected from hydroxy, halogen, C 1 -C 6 alkoxy, Ci-Cg alkyl, CF3, S(0) m CH 3 , -N(CH 3 )2/ C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 7 - Cn arylalkyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, C 1 -C 6 alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 2 -C 7 alkylcarbonyl; C 7 -C 11 arylcarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cβ alkoxy, Ci-C δ alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 1 -C 10 alkoxycarbonyl; C 4 -C 11 cycloalkoxycarbonyl; C 7 -C 1 1 bicycloalkoxycarbonyl; C7- C1 1 aryloxycarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cβ alkoxy, Ci-Ce alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; aryl(Cι-Cιo alkoxy)carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, C1-C6 alkoxy, Ci-Cβ alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; Ci-Cβ alkylcarbonyloxy(C 1 -C 4 alkoxy) carbonyl; Cβ-Cio arylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cβ alkoxy, Ci-Cβ alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 4 -C 11 eyeloalkylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl; heteroaryl optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cε alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; or heteroaryl (C 1 -C 5 )alkyl where the heteroaryl group is optionally substituted with 0-2 groups selected from hydroxy, halogen, C 1 -C6 alkoxy, Ci-C δ alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; provided that only one of R 2 and R 3 may be hydroxy; R 12 and R 13 are independently H, Ci-Cio alkyl, Ci-Cio alkoxycarbonyl, Ci-Cio alkylcarbonyl, Ci-Cio alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, arylsulfonyl, aryl(C2-Cιo alkenyl)sulfonyl, heteroarylsulfonyl, aryl, C2-C6 alkenyl, C 3 -C11 cycloalkyl, C4-C11 cycloalkylalkyl, C7-C 11 arylalkyl, C 7 -C1 1 arylcarbonyl, C 4 -C 11 cycloalkoxycarbonyl, C 7 - C1 1 bicycloalkoxycarbonyl, C 7 -C 11 aryloxycarbonyl, heteroarylcarbonyl, heteroarylalkylcarbonyl, or aryl (C 1 -C 10 alkoxy)carbonyl, wherein said aryls are optionally substituted with 0-3 substituents selected from the group consisting of: C 1 -C 4 alkyl, C 1 -C4 alkoxy, halo, CF 3 , and N0 ; R 16 is selected from: -C(=0)-0-R 18a , -C(=0)-R 18b , -C ( =0 ) N ( Rl 8b) 2 , -C(=0)NHS0 2 R 18a , -C(=0)NHC(=0)R 18b , -C(=0)NHC(=0)OR 18 , -C(=0)NHS0 2 NHR 18b , -C(=S)-NH-R 18b , -NH-C(=0)-0-R 18 , -NH-C(=0)-R 18b , -NH-C(=0)-NH-R 18b , -S0 -0-R 18 , -S0 2 -R 18a , -S0 2 -N(18 b ) 2 , -S0 2 -NHC(=0)018 b , -P(=S) (0R 18 ) 2 , -P(=0) (OR 18a ) 2 , -P(=S) (R 18a ) 2 , -P(=0) (R 18a ) 2 , or R 18a is selected from: Ci-Cs alkyl substituted with 0-2 R 19 , C 2 -C 8 alkenyl substituted with 0-2 R 19 , C 2 -C 8 alkynyl substituted with 0-2 R 19 , C 3 -C 8 cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-4 R 19 , aryl(Cι-C 6 alkyl)- substituted with 0-4 R 19 , a 5-10 membered heterocyclic ring system having 1-3 heteroatoms selected independently from O, S, and N, said heterocyclic ring being substituted with 0-4 R 19 , C 1 -C6 alkyl substituted with a 5-10 membered heterocyclic ring system having 1-3 heteroatoms selected independently from O, S, and N, said heterocyclic ring being substituted with 0-4 R 19 ; R i8b is selected from R 18a or H; R 19 is selected from H, halogen, CF 3 , CN, NO 2 , NR 12 R 13 , Ci- Cs alkyl, C 2 -C6 alkenyl, C 2 -C δ alkynyl, C 3 -C 1 1 cycloalkyl, C 4 -C1 1 cycloalkylalkyl, aryl, aryKCi-Cβ alkyl)-, Ci-Cβ alkoxy, or C 1 -C 4 alkoxycarbonyl; Y is selected from hydroxy, Ci to Cio alkyloxy, C 3 to Cn cycloalkyloxy, Cβ to Cio aryloxy, C7 to Cn aralkyloxy, C3 to Cio alkylcarbonyloxyalkyloxy, C 3 to Cio alkoxycarbonyloxyalkyloxy, C 2 to Cio alkoxycarbonylalkyloxy, C 5 to Cio cycloalkylcarbonyloxyalkyloxy, C 5 to Cio eyeloalkoxycarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonylalkyloxy, C7 to Cn aryloxycarbonylalkyloxy, Cs to Cι 2 aryloxycarbonyloxyalkyloxy, Cs to Cι 2 arylcarbonyloxyalkyloxy, C5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C 5 to Cio (5-alkyl- 1,3-dioxa-cyclopenten-2-one-yl)methyloxy, Cio to C 14 (5-aryl-l,3-dioxa-cyclopenten-2-one-yl)methyloxy, (R 2 ) (R 3 )N-(Cι-Cιo alkoxy)-; m is 0-2 ; n is 0-2 ; and p is 1-5. [17] Preferred compounds of this third embodiment are compounds of Formula III: wherein: R 1 is selected from R 2 HN-, H N(R 2 N=)C-, H2N(R 2 N=)CNH-, R 2 HN(CH 2 ) q O-, H 2 N(R 2 N=)CNH(CH 2 ) q O-, piperazinyl- (CH 2 ) q O-, R 2 (R 3 )NC(0) -, R 2 (R 5 0)N(R 2 N=)C- R 2 (R 3 )N(R 5 ON=)C-, R 2 and R 3 are selected from H; Ci-Cβ alkyl; C7-C1 1 arylalkyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cβ alkoxy, Ci-Cβ alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; aryl(Cι-Cιo alkoxy)carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-C δ alkoxy, Ci-Cβ alkyl, CF 3 , S(0) m CH3, -N(CH3) 2 / C 1 -C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; heteroaryl (C 1 -C 5 )alkyl where the heteroaryl group is optionally substituted with 0-2 groups selected from hydroxy, halogen, C 1 -C 6 alkoxy, Ci-Cβ alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C1-C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; or Ci-Cio alkoxycarbonyl; R 4 is selected from H, Ci-Cio alkyl, hydroxy, Ci-Cio alkoxy, nitro, Ci-Cio alkylcarbonyl, or -N(R 12 )R 13 ; V is selected from: a single bond (i.e., V is absent); C 1 -C 7 alkylene substituted with 0-6 R 6 or R 7 ; C 2 -C 7 alkenylene substituted with 0-4 R 6 or R 7 ; C 2 -C 7 alkynylene substituted with 0-4 R 6 or R 7 ; phenylene substituted with 0-3 R 6 or R 7 ; pyridylene substituted with 0-3 R 6 or R 7 ; pyridazinylene substituted with 0-3 R 6 or R 7 ; X is selected from - (CH 2 ) n (=0)N(R 12 )-, C 1 -C 7 alkylene substituted with 0-1 R 4 , C 2 -C 7 alkenylene, or C 2 -C 7 alkynylene; Y is selected from: hydroxy, Ci to Cio alkyloxy, C 3 to Cn eyeloalkyloxy, C6 to Cio aryloxy, C 7 to Cn aralkyloxy, C3 to Cio alkylcarbonyloxyalkyloxy, C3 to Cio alkoxycarbonyloxyalkyloxy, C 2 to Cio alkoxycarbonylalkyloxy, C5 to Cio cycloalkylcarbonyloxyalkyloxy, C to Cio eyeloalkoxycarbonyloxyalkyloxy, C 5 to Cio eyeloalkoxycarbonylalkyloxy, C 7 to Cn aryloxycarbonylalkyloxy, Cs to Cι 2 aryloxycarbonyloxyalkyloxy, Cs to C 12 arylcarbonyloxyalkyloxy, Cs to Cio alkoxyalkylcarbonyloxyalkyloxy, Cs to Cio (5-alkyl-l,3-dioxa-cyclopenten-2-one- yDmethyloxy, or Cio to C 1 (5-aryl-l,3-dioxa-cyclopenten-2-one- yl)methyloxy; Z is selected from O or CH 2 ; D, E, F and G are each independently selected from: CH 2 ; carbonyl; a heteroatom moiety selected from N, NH, 0, provided that no more than 2 of D, E, F and G are N, NH, 0 or S; alternatively, the bond between D and E, E and F, or F and G in such spiro-fused ring may be a carbon-nitrogen double bond or a carbon-carbon double bond; R 6 and R 7 are each independently selected from H, Ci-Cio alkyl, hydroxy, Ci-Cio alkoxy, nitro, Ci-Cio alkylcarbonyl, -N(R 12 )R 13 , cyano, or halo; R 12 and R 13 are each independently selected from H, Ci-Cio alkyl, Ci-Cio alkoxycarbonyl, Ci-Cio alkylcarbonyl, Ci-Cio alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, arylsulfonyl, heteroarylcarbonyl, heteroaryalkylcarbonyl or aryl; provided that n, p, q and r are chosen such that the number of atoms between R 1 and Y is in the range of 8-17. [18] Further preferred compounds of this third embodiment are compounds of Formula II wherein: R 1 is R 2 NHC(=NR 2 )- and V is phenyl or pyridyl or R 1 is and V is a single bond (i . e . V is absent ) ; n is 1 or 2 ; X is C 1 -C 4 alkylene substituted with 0-1 R 4 ; Y is selected from: hydroxy; Ci to Cio alkoxy; methylcarbonyloxymethoxy-; ethylcarbonyloxymethoxy-; t-butylcarbonyloxymethoxy-; cyclbhexylcarbonyloxymethoxy-; 1- (methylcarbonyloxy)ethoxy-; - - 1-(ethylcarbonyloxy)ethoxy-; 1- (t-butylcarbonyloxy) ethoxy-; 1- (cyclohexylcarbonyloxy)ethoxy-; i-propyloxycarbonyloxymethoxy-; t-butyloxycarbonyloxymethoxy-; 1- (i-propyloxycarbonyloxy)ethoxy-; 1- (cyclohexyloxycarbonyloxy) ethoxy-; 1- ( -butyloxycarbonyloxy)ethoxy-; dimethylaminoethoxy-; diethylaminoethoxy-; (5-methyl-1,3-dioxacyclopenten-2-on-4-y1)methoxy-; (5- ( -butyl) -1,3-dioxacyclopenten-2-on-4-yl)methoxy-; (1,3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methoxy-; 1- (2- (2-methoxypropyl) carbonyloxy) ethoxy-; R 12 and R 13 are each independently selected from H, C -Cβ alkyl, C 1 -C 4 alkoxycarbonyl, C 1 -C 4 alkylcarbonyl, Cι~ C 4 alkylsulfonyl, aryl(Cι-C 4 alkyl)sulfonyl, arylsulfonyl, heteroarylcarbonyl, heteroaryalkylcarbonyl or aryl; and R 13 is H. [19] Specifically preferred compounds of this third embodiment are compounds, or pharmaceutically acceptable salt or prodrug forms thereof, selected from: 5 (R, S) -3-(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2,8- diazaspiro[4.4]non-2-ene-7,9-dione; 5 (R, S)-3-(4-amidinophenyl)-8- (3-carboxypropyl) -l-oxa-2,8- diazaspiro[4.4]non-2-ene-7,9-dione; 5 (R, S)-3-(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2,8- diazaspiro[4.4]non-2-ene-5-one; 5 (R, S)-3-(4-amidinophenyl)-8- (3-carboxypropyl)-l-oxa-2,8- diazaspiro[4.4]non-2-ene-5-one; 5 (R, S)-3-(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2- azaspiro[4.4]nona-2,8-diene-5-one; 5 (R, S)-3-(4-amidinophenyl)-8- (3-carboxypropyl)-l-oxa-2- azaspiro[4.4]nona-2,8-diene-5-one; 5 (R, S)-3-(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2,8- diazaspiro[4.4]dec-2-ene-7,9-dione; 5 (R, S)-3-(4-amidinophenyl)-8- (3-carboxypropyl)-l-oxa-2,8- diazaspiro[4.4]dec-2-ene-7,9-dione; 5 (R, S) -3 -(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2,8- diazaspiro[4.4]dec-2-ene-5-one; 5 (R, S) -3 -(4-amidinophenyl)-8- (3-carboxypropyl)-l-oxa-2,8- diazaspiro[4.4]dec-2-ene-5-one; 5 (R, S)-3-(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2- azaspiro[4.4]deca-2,8-diene-5-one; 5 (R, S)-3-(4-amidinophenyl)-8- (3-carboxypropyl)-l-oxa-2- azaspiro[4.4]deca-2,8-diene-5-one; 5 (R, S) -3 -(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2,8- diazaspiro[4.4]undec-2-ene-7,9-dione; 5 (R, S)-3-(4-amidinophenyl)-8- (3-carboxypropyl)-l-oxa-2,8- diazaspiro[4.4]undec-2-ene-7,9-dione; 5 (R, S) -3 -(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2,8- diazaspiro[4.4]undec-2-ene-5-one; 5 (R, S)-3-(4-amidinophenyl)-8- (3-carboxypropyl)-l-oxa-2,8- diazaspiro[4.4]undec-2-ene-5-one; 5 (R, S)-3-(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2- azaspiro[4.4]undeca-2,8-diene-5-one; 5 (R, S)-3-(4-amidinophenyl)-8- (3-carboxypropyl)-l-oxa-2- azaspiro[4.4]undeca-2,8-diene-5-one; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(2-carboxyethyl)-1- oxa-2,8-diazaspiro[4.4]non-2-ene-7,9-dione; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(3-carboxypropyl) -1- oxa-2,8-diazaspiro[4.4]non-2-ene-7,9-dione; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(2-carboxyethyl)-1- oxa-2,8-diazaspiro[4.4]non-2-ene-5-one; 5 (R, S) -3 -[2-(piperidin-4-yl)ethyl]-8-(3-carboxypropyl)-1- oxa-2,8-diazaspiro[4.4]non-2-ene-5-one; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(2-carboxyethyl)-1- oxa-2-azaspiro[4.4]nona-2,8-diene-5-one; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(3-carboxypropyl)-1- oxa-2-azaspiro[4.4]nona-2,8-diene-5-one; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(2-carboxyethyl)-1- oxa-2,8-diazaspiro[4.4]dec-2-ene-7,9-dione; 5(i? £')-3-[2-(piperidin-4-yl)ethyl]-8-(3-carboxypropyl)-l- oxa-2,8-diazaspiro[4.4]dec-2-ene-5,7-dione; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(2-carboxyethyl)-1- oxa-2,8-diazaspiro[4.4]dec-2-ene-5-one; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(3-carboxypropyl) -1- oxa-2,8-diazaspiro[4.4]dec-2-ene-5-one; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(2-carboxyethyl)-1- oxa-2-azaspiro[4.4]deca-2,8-diene-5-one; 5 (R, S)-3-[2- (piperidin-4-yl)ethyl]-8- (3-carboxypropyl) -1- oxa-2-azaspiro[4.4]deca-2,8-diene-5-one; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8- (2-carboxyethyl)-1- oxa-2,8-diazaspiro[4.4]undec-2-ene-7,9-dione; 5 (R, S) -3- [2- (piperidin-4-yl)ethyl] -8- (3-carboxypropyl) -1- oxa-2, 8-diazaspiro[4.4]undec-2-ene-7, 9-dione; 5 (R, S) -3- [2- (piperidin-4-yl)ethyl] -8- (2-carboxyethyl) -1- oxa-2,8-diazaspiro[4.4]undec-2-ene-5-one; 5 (R, S) -3- [2- (piperidin-4-yl) ethyl] -8- (3-carboxypropyl) -1- oxa-2, 8-diazaspiro[4.4]undec-2-ene-5-one; 5 (R, S) -3- [2- (piperidin-4-yl)ethyl] -8- (2-carboxyethyl) -1- oxa-2-azaspiro[4.4]undeca-2, 8-diene-5-one; 5 (R, S) -3- [2- (piperidin-4-yl)ethyl] -8- (3-carboxypropyl) -1- oxa-2-azaspiro[4.4]undeca-2, 8-diene-5-one; 5 (R,S) -3- (4-amidinophenyl) -8- [2- (benzyloxycarbonylamino) - 2-carboxyethyl] -l-oxa-2,8-diazaspiro[4.5]dec-2-ene. [20] A fourth embodiment of this invention provides compounds of Formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein: R 1 is selected from: R 2 (R 3 )N(CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)C(CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)CN(R 2 ) (CH 2 ) q Z-, piperazinyl- (CH 2 ) q Z- or Z is selected from 0, S , S ( =0) , S ( =0) 2 ; R 2 and R 3 are independently selected from: H, Ci-Cio alkyl , C2-C 6 alkenyl , C 3 -C 11 cycloalkyl , C 4 -C 11 cycloalkylalkyl , C 6 -Cιo aryl , C7-C11 arylalkyl , C 2 -C 7 alkylcarbonyl, C7-C 11 ary1carbony1, C 2 -Cιo alkoxycarbonyl, C 4 -C 11 cycloalkoxycarbonyl, C 7 -C 11 bicycloalkoxycarbonyl, C 7 -C 11 aryloxycarbonyl, or aryl (C1-C 1 0 alkoxy)carbonyl, Ci-Cg alkylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl, Cg-Cio arylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl, C 4 -C 11 cycloalkylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl; U is optionally present and is selected from C 1 -C 7 alkylene, C -C7 alkenylene, C 2 -C 7 alkynylene, arylene, or pyridylene; V is selected from: - a single bond (i.e., V is absent); C 1 -C7 alkylene substituted with 0-6 R 6 or R 7 ; C 2 -C7 alkenylene substituted with 0-4 R 6 or R 7 ; C 2 -C7 alkynylene substituted with 0-4 R 6 or R 7 ; phenylene substituted with 0-4 R 6 or R 7 ; pyridylene substituted with 0-3 R 6 or R 7 ; pyridazinylene substituted with 0-3 R 6 or R 7 ; W is -(aryl)-Z 1 -, wherein said aryl is substituted with 0-6 R 6 or R 7 ; Z 1 is selected from a single bond (i.e., Z 1 is absent), -CH 2 -, O or S; X is selected from: a single bond (i.e., X is absent); C 1 -C 7 alkylene substituted with 0-6 R 4 , R 8 or R 15 ; C 2 -C 7 alkenylene substituted with 0-4 R 4 , R 8 or R 15 ; C 2 -C 7 alkynylene substituted with 0-4 R 4 , R 8 or R 15 ; Y is selected from hydroxy, Ci to Cio alkyloxy, C 3 to Cn cycloalkyloxy, Cg to Cio aryloxy, C7 to Cn aralkyloxy, C 3 to Cio alkylcarbonyloxyalkyloxy, C3 to Cio alkoxycarbonyloxyalkyloxy, C 2 to Cio alkoxycarbonylalkyloxy, C 5 to Cio cycloalkylcarbonyloxyalkyloxy, C5 to Cio cycloalkoxycarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonylalkyloxy, C 7 to Cn aryloxycarbonylalkyloxy, Cs to Cι 2 aryloxycarbonyloxyalkyloxy, Cs to Cι 2 arylcarbonyloxyalkyloxy, C 5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C 5 to Cio (5-alkyl- 1,3-dioxa-cyclopenten-2-one-yl)methyloxy, Cio to C 14 (5-aryl-l,3-dioxa-cyclopenten-2-one-yl)methyloxy; (R 2 ) (R 3 )N-(Cι-Cιo alkoxy)-; R 4 is selected from H, C 1 -C 10 alkyl, hydroxy, C 1 -C 1 0 alkoxy, nitro, C 1 -C 1 0 alkylcarbonyl, or -N(R 12 )R 13 ; R 6 and R 7 are each independently selected from H, C 1 -C 10 alkyl, hydroxy, C1-C 10 alkoxy, nitro, C 1 -C 10 alkylcarbonyl, -N(R 12 )R 13 , cyano, halo, CF 3 , CHO, C0 2 R 5a , C(=0)R 5 , CONHR 5 , CON(R 12 ) 2 , OC(=0)R 5 , OC(=0)OR 5 , OR 5a , 0C(=0)N(R 12 ) 2 , OCH 2 C0 2 R 5a , C0 2 CH 2 C0 2 R 5 , N(R 12 ) 2 , N0 2 , NR 12 C (=0)R 5a , NR 12 C (=0) 0R 5 , NR 12 C(=0)N(R 12 ) 2 , NR 12 S0 2 N(R 12 ) 2 , NR 12 S0 2 R 5a , S(0) p R 5a , S0 2 N(R 12 ) 2 f C 2 to Cg alkenyl, C 3 to Cn cycloalkyl, C4 to Cn cycloalkylmethyl; Cg to Cio aryl optionally substituted with halogen, alkoxy, alkyl, -CF 3 , S(0)m e, or -NMe 2 ; or C 7 to Cn arylalkyl said aryl being optionally substituted with halogen, alkoxy, alkyl, -CF 3 , S(0) m Me, or -NMe 2 ; R 8 is selected from: H; R 6 ; C 1 -C 10 alkyl, substituted with 0-8 R 6 ; C2-C 1 0 alkenyl, substituted with 0-6 R 6 ; C2-C 1 0 alkynyl, substituted with 0-6 R 6 ; C 3 -C8 cycloalkyl, substituted with 0-6 R 6 ; Cs-Cg cycloalkenyl, substituted with 0-5 R 6 ; aryl, substituted with 0-5 R 6 ; 5-6 membered heterocyclic ring containing 1-2 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-5 R 6 ; R 12 and R 13 are independently H, C 1 -C 10 alkyl, C 1 -C 10 alkoxycarbonyl, C 1 -C 10 alkylcarbonyl, C 1 -C 10 alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, arylsulfonyl, aryl, C 2 -Cg alkenyl, C 3 -C 11 cycloalkyl, C4-C11 cycloalkylalkyl, C7-C11 arylalkyl, C 2 -C7 alkylcarbonyl, C7-C 11 arylcarbonyl, C 2 -Cιo alkoxycarbonyl, C 4 -C 11 cycloalkoxycarbonyl, C 7 -C 11 bicycloalkoxycarbonyl, C 7 -C1 1 aryloxycarbonyl, heteroarylcarbonyl, heteroarylalkylcarbonyl or aryl(Cι-Cιo alkoxy)carbonyl; R 14 is selected from H, C1-C1 0 alkyl, C 2 -Cιo alkenyl, C 2 - C1 0 alkynyl, C1-C 10 alkoxy, aryl, heteroaryl or C 1 -C 10 alkoxycarbonyl, C0 2 R 5 or -C (=0)N(R 12 )R 13 ; R 5 and R 5a are selected independently from H, Ci to Cs alkyl, C 2 to Cg alkenyl, C 3 to Cn cycloalkyl, C4 to Cn cycloalkylmethyl, Cg to Cio aryl, C 7 to Cn arylalkyl, or C 1 -C 10 alkyl substituted with 0-8 R 4 ; R 15 is selected from: H; R 6 ; C 1 -C 10 alkyl, substituted with 0-8 R 6 ; C2-C 10 alkenyl, substituted with 0-6 R 6 ; i-Cio alkoxy, substituted with 0-6 R 6 ; aryl, substituted with 0-5 R 6 ; 5-6 membered heterocyclic ring containing 1-2 N, 0, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-5 R 6 ; Ci-Cio alkoxycarbonyl substituted with 0-8 R 6 ; CO2R 5 ; or -C(=0)N(R 12 )R 13 ; n is 0-4; q is 2-7; r is 0-3, provided that n, q, and r are chosen such that the number of atoms between R 1 and Y is about 8-17. [21] Preferred compounds of this fourth embodiment are those of Formula IV: wherein: R 1 is selected from R 2 HN(CH 2 ) q O-, R 2 HN(R 2 N=C)NH(CH 2 ) q O-, piperazinyl-(CH 2 )qO-, or Z is O; R 2 is selected from H, aryl(C 1 -C 10 )alkoxycarbonyl, C 1 -C 10 alkoxycarbonyl; V is selected from: a single bond (i.e., V is absent); C 1 -C 7 alkylene substituted with 0-6 R 6 or R 7 ; C 2 -C 7 alkenylene substituted with 0-4 R 6 or R 7 ; C 2 -C 7 alkynylene substituted with 0-4 R 6 or R 7 ; phenylene substituted with 0-3 R 6 or R 7 ; pyridylene substituted with 0-3 R 6 or R 7 ; pyridazinylene substituted with 0-3 R 6 or R 7 ; Z 1 is selected from a single bond (i.e., Z 1 is absent), O or S; X is selected from: a single bond (i.e., X is absent); C 1 -C 7 alkylene substituted with 0-4 R 4 , R 8 or R 15 ; C 2 -C 7 alkenylene substituted with 0-3 R 4 , R 8 or R 15 ; C 2 -C 7 alkynylene substituted with 0-3 R 4 , R 8 or R 15 ; Y selected from hydroxy, Ci to Cio alkyloxy, C 3 to Cn cycloalkyloxy, Cg to Cio aryloxy, C 7 to Cn aralkyloxy, C 3 to Cio alkylcarbonyloxyalkyloxy, C 3 to Cio alkoxycarbonyloxyalkyloxy, C 2 to Cio alkoxycarbonylalkyloxy, C 5 to Cio cycloalkylcarbonyloxyalkyloxy, C5 to Cio cycloalkoxycarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonylalkyloxy, C 7 to Cn aryloxycarbonylalkyloxy, Cs to Cι 2 aryloxycarbonyloxyalkyloxy, Cs to Cι 2 arylcarbonyloxyalkyloxy, C 5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C 5 to Cio (5-alkyl- 1,3-dioxa-cyclopenten-2-one-yl)methyloxy, or Cio to C 14 (5-aryl-l,3-dioxa-cyclopenten-2-one-yl)methyloxy; R 4 is selected from H, C 1 -C 10 alkyl, hydroxy, C 1 -C 10 alkoxy, nitro, C1-C 10 alkylcarbonyl, or -N(R 12 )R 13 ; R 6 and R 7 are selected from H, Ci-Cio alkyl, hydroxy, Ci-Cio alkoxy, nitro, Ci-Cio alkylcarbonyl, -N(R 12 )R 13 , cyano, or halo; R 8 is selected from H, Ci-Cio alkyl, C 2 -C 10 alkenyl, C3- Cβ cycloalkyl, Cs-Cg cycloalkenyl, aryl, 5-6 membered heterocyclic ring containing 1-2 N, 0, or S, where said heterocyclic ring may be saturated, partially saturated, or fully unsaturated; R 12 and R 13 are independently selected from H, C 1 -C 10 alkyl, C 1 -C 1 0 alkoxycarbonyl, C 1 -C 1 0 alkylcarbonyl, C 1 -C 1 0 alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, arylsulfonyl, heteroarylcarbonyl, heteroarylalkylcarbonyl or aryl; R 14 is selected from H, C 1 -C 10 alkyl, C 2 -Cιo alkenyl, C 2 - C10 alkynyl, C 1 -C 1 0 alkoxy, aryl, heteroaryl or C 1 -C 10 alkoxycarbonyl, CO 2 R 5 or -C(=0)N(R 12 )R 13 ; R 5 is selected from H or C 1 -C 10 alkyl substituted with 0-6 R 4 ; n is 0-4; q is 2-7; provided that n and q are chosen such that the number of atoms between R 1 and Y is in the range of 8-17. [22] Further preferred compounds of this fourth embodiment are compounds of Formula IV wherein: R 1 is R 2 HN(CH 2 ) q O- Or V is C 1 -C 3 alkylene; Z 1 is a single bond (i.e. Z 1 is absent) or 0; X is C 1 -C 3 alkylene substituted with 0-1 R 4 ; Y is selected from: hydroxy; Ci to Cio alkoxy; ethylcarbonyloxymethoxy-; ethylcarbonyloxymethoxy-; t-butylcarbonyloxymethoxy-; cyclohexylcarbonyloxymethoxy-; 1- (methylcarbonyloxy)ethoxy-; 1- (ethylcarbonyloxy)ethoxy-; 1- (t-butylcarbonyloxy) ethoxy-; 1- (cyclohexylcarbonyloxy)ethoxy-; i-propyloxycarbonyloxymethoxy-; t-butyloxycarbonyloxymethoxy-; 1- (i-propyloxycarbonyloxy)ethoxy-; 1- (cyclohexyloxycarbonyloxy) ethoxy-; 1- ( -butyloxycarbonyloxy)ethoxy-; dimethylaminoethoxy-; diethylaminoethoxy-; (5-methyl-l,3-dioxacyclopenten-2-on-4-yl)methoxy-; (5- ( t-butyl) -1,3-dioxacyclopenten-2-on-4-yl)methoxy-; (1,3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methoxy-; 1- (2- (2-methoxypropyl) carbonyloxy) ethoxy-; R 12 and R 13 are independently selected from H, Ci-Cg alkyl, C 1 -C4 alkoxycarbonyl, C1-C 4 alkylcarbonyl, Ci-Cg alkylsulfonyl, aryl(Cι-C 4 alkyl)sulfonyl, arylsulfonyl, heteroarylcarbonyl, heteroarylalkylcarbonyl or aryl; R 13 is H . [23] Specifically preferred compounds of this fourth embodiment are compounds, or pharmaceutically acceptable salt or prodrug forms thereof, selected from: 5 (R, S)-4-[3-(piperidin-4-yl)oxymethylisoxazolin-5-yl]hy- drocinnamic acid; 5 (R, S)-4-[3-(2-aminoethoxymethyl)isoxazolin-5-yl]hydro- cinnamic acid; 5 (R, S)-4-[3-(3-aminopropyloxymethyl)isoxazolin-5-yl]hy- drocinnamic acid; 5 (R, S)-4-[3-(piperidin-4-yl)oxymethylisoxazolin-5- yl]phenoxyacetic acid; 5 (R, S) -A- [3 -(2-aminoethoxymethyl)isoxazolin-5-yl]phen- oxyacetic acid; 5 (R, S)-4-[3-(3-aminopropyloxymethyl)isoxazolin-5- yl]phenoxyacetic acid. [24] A fifth embodiment of this invention provides a compound of Formula I: or a pharmaceutically acceptable salt or prodrug form thereof wherein: b is a single or double bond; R 1 is selected from R 2a (R 3 )N-, R 2 (R 3 )N(R 2 N=)C-, R 2a (R 3 )N(CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)C(CH ) q Z-, R 2 (R 3 )NC(O)-, R 2 (R 5 0)N(R 2 N=)C-, R 2 (R 3 )N(R 5 ON=)C-; Z is selected from a bond (i.e. is absent), 0, S, S(=0), S(=0 ) 2 ; R 2 and R 3 are independently selected from: H; Ci-Cio alkyl; C3-Cg alkenyl; C 3 -C 1 1 cycloalkyl; C4-C 11 cycloalkylalkyl; Cg-Cio aryl optionally substituted with 0-3 groups selected from hydroxy, halogen, Cι~Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C1-C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 7 - C11 arylalkyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Cι~Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 2 -C 7 alkylcarbonyl; C 7 -C 11 arylcarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 / C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 1 -C 10 alkoxycarbonyl; C 4 -C 11 cycloalkoxycarbonyl; C 7 -C 11 bicycloalkoxycarbonyl; C 7 - C 11 aryloxycarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Cι~Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; aryl (C 1 -C 10 alkoxy)carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Cι~Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; Ci-Cg alkylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl; Cg-Cio arylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 4 -C 11 cycloalkylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl; heteroaryl optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; or heteroaryl(C 1 -C 5 )alkyl where the heteroaryl group is optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; provided that only one of R 2 and R 3 may be hydroxy; R 2a _ is R 2 or R 2 (R 3 )N(R 2 N=)C; U is selected from: a single bond (i.e., U is not present), -(C 1 -C7 alkyl)-, -(C -C 7 alkenyl)-, -(C 2 -C7 alkynyl)-, -(aryl)- substituted with 0-3 R 6a , or -(pyridyl)- substituted with 0-3 R 6 ; V is selected from: a single bond (i.e., V is not present); -(C 1 -C 7 alkyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(C 2 -C 7 alkenyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(C 2 -C 7 alkynyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(phenyl)-, substituted with 0-2 groups independently selected from R 6 or R 7 ; -(pyridyl)-, substituted with 0-2 groups independently selected from R 6 or R 7 ; or -(pyridazinyl)-, substituted with 0-2 groups independently selected from R 6 or R 7 ,- is selected from: X is selected from: a single bond (i.e. X is absent) -(C(R ) 2 ) n -C(R 4 ) (R 8 )-C(R 4 ) (R a )-, with the proviso that when n is 0 or 1, then at least one of R a or R 8 is other than H or methyl; Y is selected from: hydroxy, Ci to Cio alkyloxy, C 3 to Cn cycloalkyloxy, Cg to Cio aryloxy, C 7 to Cn aralkyloxy, C 3 to Cio alkylcarbonyloxyalkyloxy, C 3 to Cio alkoxycarbonyloxyalkyloxy, C 2 to Cio alkoxycarbonylalkyloxy, Cs to Cio cycloalkylcarbonyloxyalkyloxy, C5 to Cio eyeloalkoxycarbonyloxyalkyloxy, C5 to Cio eyeloalkoxycarbonylalkyloxy, C7 to Cn aryloxycarbonylalkyloxy, Cs to Cι 2 aryloxycarbonyloxyalkyloxy, Cβ to Cι 2 arylcarbonyloxyalkyloxy, C 5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C 5 to Cio (5-alkyl-l,3-dioxa-cyclopenten-2-one- yl)methyloxy, Cio to C 1 4 (5-aryl-l,3-dioxa-cyclopenten-2-one- yl)methyloxy, ( R 2 ) (R 3 )N-(Cι-Cιo alkoxy)-; Z 1 is -C-, -0-, or -NR 22 -; Z 2 is -0-, or -NR 22 -; R 4 is selected from H, C 1 -C 10 alkyl, C 1 -C 10 alkylcarbonyl, aryl, arylalkylene cycloalkyl, or cycloalkylalkylene; alternately, two R 4 groups on adjacent carbons may join to form a bond (i.e. a carbon-carbon double or triple bond) ; R a is selected from H, hydroxy, C 1 -C 10 alkoxy, nitro, N(R 5 )R 5a , -N(R 12 )R 13 , -N(R 16 )R 17 , C 1 -C1 0 alkyl substituted with 0-3 R 6 , aryl substituted with 0-3 R 6 , or C 1 -C 1 0 alkylcarbonyl; R 4b is selected from H, Ci-Cg alkyl, C 2 -Cg alkenyl, C 2 -Cg alkynyl, hydroxy, Ci-Cg alkoxy, Ci-Cg alkylthio, Ci-Cg alkylsulfinyl, Ci-Cg alkylsulfonyl, nitro, Ci-Cg alkylcarbonyl, Cg-Cio aryl, -N(R 12 )R 13 ; halo, CF 3 , CN, Ci-Cg alkoxycarbonyl, carboxy, piperidinyl, or pyridyl; R 5 is selected from H, Ci-Cs alkyl, C -Cg alkenyl, C 3 -C 11 cycloalkyl, C4-C 11 cycloalkylmethyl, Cg-Cio aryl, C7- C 11 arylalkyl, or C 1 -C 10 alkyl substituted with 0-2 R b ; R 5a is selected from hydrogen, hydroxy, Ci to Cs alkyl, C 2 to Cg alkenyl, C 3 to Cn cycloalkyl, C4 to Cn cycloalkylmethyl, Ci-Cg alkoxy, benzyloxy, Cg to Cio aryl, heteroaryl, C 7 to Cn arylalkyl, or C 1 -C 10 alkyl substituted with 0-2 R 4b ; alternately, R 5 and R 5a when both are substituents on the same nitrogen atom (as in -NR 5 R 5a ) can be taken together with the nitrogen atom to which they are attached to form 3-azabicyclononyl, 1,2,3,4- tetrahydro-1-quinolinyl, 1,2,3, 4-tetrahydro-2- isoquinolinyl, 1-piperidinyl, 1-morpholinyl, 1- pyrrolidinyl, thiamorpholinyl, thiazolidinyl or 1- piperazinyl, each being optionally substituted with Ci-Cg alkyl, Cg-Cio aryl, heteroaryl, C7-C1 1 arylalkyl, Ci-Cg alkylcarbonyl, C 3 -C 7 cycloalkylcarbonyl, Ci-Cg alkoxycarbonyl, C 7 -C 11 arylalkoxycarbonyl, Ci-Cg alkylsulfonyl or Cg-Cio arylsulfonyl; R 5b is selected from Ci-Cs alkyl, C 2 -Cg alkenyl, C 3 -C 11 cycloalkyl, C 4 -C 11 cycloalkylmethyl, Cg-Cio aryl, C 7 - C 11 arylalkyl, or C 1 -C 10 alkyl substituted with 0-2 R 4b ; R 6 is selected from H, C 1 -C 10 alkyl, hydroxy, C 1 -C 10 alkoxy, nitro, C 1 -C 10 alkylcarbonyl, -N(R 12 )Ri- 3 , cyano, halo, CF 3 , CHO, CO 2 R 5 , C(=0)R 5a , C0NR 5 R 5a , OC(=0)R 5a , OC(=0)OR 5b , OR 5 , OC (=0)NR 5 R 5a , OCH2CO 2 R 5 , Cθ 2 CH 2 C0 2 R 5 , N0 2 , NR 5a C(=0)R 5 , NR 5a C(=0)OR 5b , NR 5a C(=0)NR 5 R 5a , NR 5a Sθ2NR 5 R 5 , NR 5a S0 2 R 5 , S(0) p R 5 , S0 2 NR 5 R 5 , C 2 to Cg alkenyl, C 3 to Cn cycloalkyl, C 4 to Cn cycloalkylmethyl; Cg to Cio aryl optionally substituted with 1-3 groups selected from halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0)mMe, or -NMe 2 ; C 7 to Cn arylalkyl, said aryl being optionally substituted with 1-3 groups selected from halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0)m e, or -NMe 2 ; ethylenedioxy when R 6 is a substiuent on aryl; or a 5-6 membered heterocyclic ring containing 1-2 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 7 ; R 6a is selected from C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , N0 2 , or NR 12 R 13 ; R 7 is selected from H, C 1 -C 10 alkyl, hydroxy, C 1 -C 10 alkoxy, nitro, C 1 -C 10 alkylcarbonyl, -N(R 12 )R 13 , cyano, halo, CF 3 , CHO, CO 2 R 5 , C(=0)R 5 , C0NR 5 R 5a , OC(=0)R 5 , OC(=0)OR 5b , OR 5 , OC (=0)NR 5 R 5a , OCH 2 CO 2 R 5 , C0 2 CH 2 C0 2 R 5 , N0 , NR 5a C(=0)R 5a , NR 5a C (=0)OR 5b , NR 5a C(=0)NR 5 R 5a , NR 5a S0 2 NR 5 R 5a , NR 5 S0 2 R 5 , S(0) m R 5a , Sθ2NR 5 R 5a , C 2 to Cg alkenyl, C 3 to Cn cycloalkyl, C 4 to Cn cycloalkylmethyl, Cg to Cio aryl, or C 7 to Cn arylalkyl; R 8 is selected from: R 6 ; C 2 -Cιo alkyl, substituted with 0-3 R 6 ; C2-C1 0 alkenyl, substituted with 0-3 R 6 ; C 2 -C10 alkynyl, substituted with 0-3 R 6 ; C 3 -C 8 cycloalkyl, substituted with 0-3 R 6 ; C 5 -Cg cycloalkenyl, substituted with 0-3 R 6 ; aryl, substituted with 0-3 R 6 ; 5-6 membered heterocyclic ring containing 1-2 N, 0, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 6 ; R 12 and R 13 are independently H, Ci-Cio alkyl, Ci-Cio alkoxycarbonyl, Ci-Cio alkylcarbonyl, Ci-Cio alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, arylsulfonyl, aryl, C 2 -Cg alkenyl, C 3 -C 11 cycloalkyl, C4-C11 cycloalkylalkyl, C7-C11 arylalkyl, C7-C 1 1 arylcarbonyl, C 4 -C 11 cycloalkoxycarbonyl, C 7 -C1 1 bicycloalkoxycarbonyl, C 7 -C 11 aryloxycarbonyl, or aryl (C1-C 10 alkoxy)carbonyl, wherein said aryls are optionally substituted with 0-3 substituents selected from the group consisting of: C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , and N0 2 ; R 14 is selected from H, C1-C1 0 alkyl, C 2 -Cιo alkenyl, -C 2 - C10 alkynyl, C 1 -C 1 0 alkoxy, aryl, heteroaryl or C 1 -C 10 alkoxycarbonyl, C0 2 R 5 or -C(=0)N(R 5 )R 5 ; R 15 is selected from: H; R 6 ; C1-C 10 alkyl, substituted with 0-3 R 6 ; C 2 -C 10 alkenyl, substituted with 0-3 R 6 ; C1-C 10 alkoxy, substituted with 0-3 R 6 ; aryl, substituted with 0-3 R 6 ; 5-6 membered heterocyclic ring containing 1-2 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 6 ; C 1 -C10 alkoxycarbonyl substituted with 0-2 R 6 ; -C0 2 R 5 ; or -C(=0)N(R 12 )R 13 ; provided that when b is a double bond, only one of R 14 or R 15 is present; R 16 is selected from: -C(=0)-0-R 18 , -C(=0)-R 18b , -C(=0)N(R 18b ) 2 , -C(=0)NHS0 2 R 18a , -C(=0)NHC(=0)R 18b , -C(=0)NHC(=0)OR 18 , -C(=0)NHS0 2 NHR 18b , -C(=S)-NH-R 18b , -NH-C(=0)-0-R 18a , -NH-C(=0)-R 18b , -NH-C(=0)-NH-R 18b , -S0 2 -0-R 18a , -S0 2 -R 18a , -S0 2 -N(18 b ) 2 , -S0 -NHC(=0)018 , -P(=S) (OR 18a ) 2 , -P(=0) (OR 18 ) 2 , -P(=S) (R 18a ) 2 , -P(=0) (R 18a ) 2 , or R 17 is J seClecteOd from: H, Ci-Cio alkyl, C 2 -Cg alkenyl, C 3 -C 11 cycloalkyl, C 4 -C 15 cycloalkylalkyl, aryl, aryl(Cι-Cιo alkyl)-; R 18 is selected from: Ci-Cs alkyl substituted with 0-2 R 19 , C 2 -C δ alkenyl substituted with 0-2 R 19 , C 2 -C 8 alkynyl substituted with 0-2 R 19 , C 3 -C 8 cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-4 R 19 , aryl(Cι-Cg alkyl)- substituted with 0-4 R 19 , a 5-10 membered heterocyclic ring system having 1-3 heteroatoms selected independently from O, S, and N, said heterocyclic ring being substituted with 0-4 R 19 , Ci-Cg alkyl substituted with a 5-10 membered heterocyclic ring system having 1-3 heteroatoms selected independently from O, S, and N, said heterocyclic ring being substituted with 0-4 R 19 ; R i 8 b is selected from R 18 or H; R 19 is selected from H, halogen, CF 3 , CN, N0 2 , NR 12 R 13 , Ci- Cβ alkyl, C 2 -Cg alkenyl, C 2 -Cg alkynyl, C 3 -C11 cycloalkyl, C 4 -C 11 cycloalkylalkyl, aryl, aryl(Cι-Cg alkyl)-, Ci-Cg alkoxy, or C 1 -C 4 alkoxycarbonyl; R 20 and R 21 are each independently selected from H, C 1 -C 10 alkyl, C0 2 R 5 , C(=0)R 5a , CONR 5 R 5a , NR 5 C(=0)R 5 , NR 12 R 13 , C -Cg alkenyl, C 3 -C 11 cycloalkyl, C 4 -C 11 cycloalkylmethyl, Cg-Cio aryl, or C 7 -C 11 arylalkyl; R 22 is selected from C 1 -C1 0 alkyl, C 2 -Cg alkenyl, C 3 -C 11 cycloalkyl, C 4 -C 15 cycloalkylalkyl, aryl, aryl(Cι-Cιo alkyl)-; C(=0)R 5a , C0 2 R 5b , -C(=0)N(R 5 )R 5a , or a bond to X; provided that n, q and r are chosen such that the number of atoms connecting R 1 and Y is in the range of 8-17. [25] Preferred compounds of this embodiment are those compounds of Formula Ic: (Ic ) wherein: Z is selected from a bond (i.e. is absent), 0, or S; R 2 and R 3 are independently selected from: H; Ci-Cg alkyl; C7-C 11 arylalkyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C1-C10 alkoxycarbonyl; aryl(Cι-Cιo alkoxy)carbony1 where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; or heteroaryl (C1-C5)alkyl where the heteroaryl group is optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; U is a single bond (i.e., U is not present); X is -CHR a -; R 5 is selected from H or C 1 -C 10 alkyl substituted with 0-6 R 4 ; R 6 and R 7 are each independently selected from H, C 1 -C 10 alkyl, hydroxy, C 1 -C10 alkoxy, nitro, C 1 -C1 0 alkylcarbonyl, -N(R 12 )R 13 , cyano, or halo; R 12 and R 13 are each independently selected from H, C 1 -C 10 alkyl, C 1 -C 10 alkoxycarbonyl, C 1 -C 10 alkylcarbonyl, C 1 -C10 alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, arylsulfonyl, or aryl, wherein said aryls are optionally substituted with 0-3 substituents selected from the group consisting of: C1-C 4 alkyl, C 1 -C4 alkoxy, halo, CF 3 , and N0 2 ; R 15 is selected from H, C1-C 10 alkyl, C 2 -Cιo alkenyl, C 2 - C 1 0 alkynyl, C 1 -C 10 alkoxy, aryl, heteroaryl or C 1 -C 1 0 alkoxycarbonyl, CO2R 5 or -C (=0)N(R 5 )R 5a ; R 16 is selected from: -C(=0)-0-R 18a , -C(=0)-R 18b , -S ( =0 ) 2 -R 18a ; R 17 is selected from: H or C 1 -C 4 alkyl; i8a is selected from: Ci-Cs alkyl substituted with 0-2 R 19 , C2-C 8 alkenyl substituted with 0-2 R 19 , C2-C 8 alkynyl substituted with 0-2 R 19 , C3-C 8 cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-2 R 19 , aryl (Ci-Cg alkyl)- substituted with 0-2 R 19 , a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, isoxazolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-2 R l9 ; Ci-Cg alkyl substituted with a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolinyl, benzofuranyl, indolyl, indolenyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, indolyl, carbazole, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-2 R 19 . [26] Further preferred compounds of this embodiment are compounds of Formula lb: (lb) wherein: R 1 is selected from: R 2 <R 3 )N-, R 2 NH(R 2 N=)C-, R 2 R 3 N(CH 2 ) p -Z-, R 2 NH(R 2 N=)CNH(CH 2 ) p .Z-, R 2 (R 3 )NC(0) -, R 2 (R 5 0)N(R 2 N=)C-, R 2 (R 3 ) (R 5 ON=)C-; n is 0-1; p' is 2-4; p" is 4-6; Z is selected from a bond (i.e. is absent) or O; R 3 is H or C 1 -C 5 alkyl; V is a single bond (i.e., V is not present), or -(phenyl)-; X is selected from: -CH 2 -, -CHN(R 16 )R 17 -, or -CHNR 5 R 5a -; Y is selected from: hydroxy; Ci to Cio alkoxy; methylcarbonyloxymethoxy-; ethylcarbonyloxymethoxy-; t-butylcarbonyloxymethoxy-; cyclohexylcarbonyloxymethoxy-; 1- (methylcarbonyloxy)ethoxy-; 1-(ethylcarbonyloxy)ethoxy-; 1- (t-butylcarbonyloxy) ethoxy-; 1- (cyclohexylcarbonyloxy)ethoxy-; i-propyloxycarbonyloxymethoxy-; t-butyloxycarbonyloxymethoxy-; 1- (i-propyloxycarbonyloxy)ethoxy-; 1- (cyclohexyloxycarbonyloxy) ethoxy-; 1- ( -butyloxycarbonyloxy)ethoxy-; dime hylaminoethoxy-; diethylaminoethoxy-; (5-methyl-1,3-dioxacyclopenten-2-on- -yl)methoxy-; (5- ( -butyl) -1,3-dioxacyclopenten-2-on-4-yl)methoxy-; (1,3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methoxy-; 1- (2- (2-methoxypropyl) carbonyloxy) ethoxy-; i8a is selected from: C 1 -C 4 alkyl substituted with 0-2 R 19 , C 2 -C4 alkenyl substituted with 0-2 R 19 , C2-C 4 alkynyl substituted with 0-2 R 19 , C 3 -C4 cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-2 R 19 , aryl(Cι-C 4 alkyl)- substituted with 0-2 R 19 , a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, isoxazolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-2 R l9 ; Ci-Cg alkyl substituted with a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolinyl, benzofuranyl, indolyl, indolenyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, indolyl, carbazole, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-2 R 19 . [27] Further preferred compounds of this fifth embodiment are compounds of Formula lb wherein: R 1 is R 2 NH(R 2 N=)C- or R 2 NH(R 2 N=)CNH- and V is phenyl or pyridyl; or R 1 is , and V is a single bond (i.e. V is absent) n is 1-2; X is selected from: -CH2-, -CHN(R 16 )R 17 -, or -CHNR 5 R 5a -; is selected from: methylcarbonyloxymethoxy-; ethylcarbonyloxymethoxy-; t-butylcarbonyloxymethoxy-; cyclohexylcarbonyloxymethoxy-; 1- (methylcarbonyloxy)ethoxy-; 1- (ethylcarbonyloxy)ethoxy-; 1- (t-butylcarbonyloxy) ethoxy-; 1- (cyclohexylcarbonyloxy)ethoxy-; i-propyloxycarbonyloxymethoxy-; t-butyloxycarbonyloxymethoxy-; 1- (i-propyloxycarbonyloxy)ethoxy-; 1- (cyclohexyloxycarbonyloxy)ethoxy-; 1- ( t-butyloxycarbonyloxy)ethoxy-; dimethylaminoethoxy-; diethylaminoethoxy-; (5-methyl-l,3-dioxacyclopenten-2-on-4-yl)methoxy-; (5- ( -butyl) -1,3-dioxacyclopenten-2-on-4-yl)methoxy-; (1,3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methoxy-; 1- (2- (2-methoxypropyl) carbonyloxy) ethoxy-; R 19 is H, halogen, C1-C 4 alkyl, C 3 -C7 cycloalkyl, cyclopropylmethyl, aryl, or benzyl; R 20 and R 21 are both H; R 22 is H, C1-C4 alkyl or benzyl. [28] Specifically preferred compounds of this fifth embodiment are compounds of Formula lb, or pharmaceutically acceptable salt forms thereof, selected from: 2-(R,S)-2-carboxymethyl-l-{5-(R,S)-N-[3-(4- amidinophenyl) isoxazolin-5-yl acetyl]piperidine; 2- (R,S) -2-carboxymethyl-l-{5- (R,S) -N- [3- (4- amidinophenyl) isoxazolin-5-yl acetyl]azepine; 2-(R,S)-2-carboxymethyl-l-{5-(R,S)-N-[3-(4- amidinophenyl)isoxazolin-5-yl acetyl]pyrrolidine; 3-(R,S)-carboxymethyl-4-{5-(R,S)-N-[3-(4- amidinophenyl)isoxazolin-5-yl acetyl]piperazine-2- one; 6-(R,S)-carboxymethyl-l-{5-(R,S)-N-[3-(4- amidinophenyl)isoxazolin-5-yl acetyl]piperidine-2- one; 5-(R,S)-carboxymethyl-l-{5-(R,S)-N-[3-(4- amidinophenyl)isoxazolin-5-yl acetyl]pyrrolidine-2- one; 7-(R,S)-carboxymethyl-l-{5-(R,S)-N-[3-(4- amidinophenyl)isoxazolin-5-yl acetyl]azetidine-2-one; 2-(R,S)-carboxymethyl-l-{5-(R,S)-N-[3-(4- amidinophenyl)isoxazolin-5-yl acetyl]pyrazolidine; 3-(R,S)-carboxymethyl-4-{5-(R,S)-N-[3-(4- amidinophenyl)isoxazolin-5-yl acetyl]morpholine. In the present invention it has been discovered that the compounds of Formula I above are useful as inhibitors of cell-matrix and cell-cell adhesion processes. The present invention includes novel compounds of Formula I and methods for using such compounds for the prevention or treatment of diseases resulting from abnormal cell adhesion to the extracellular matrix which comprises administering to a host in need of such treatment a therapeutically effective amount of such compound of Formula I. In the present invention it has also been discovered that the compounds of Formula I above are useful as inhibitors of glycoprotein Ilb/IIIa (GPIIb/IIIa) . The compounds of the present invention inhibit the activation and aggregation of platelets induced by all known endogenous platelet agonists. The present invention also provides pharmaceutical compositions comprising a compound of Formula I and a pharmaceutically acceptable carrier. The compounds of Formula I of the present invention are useful for the treatment (including prevention) of thromboembolic disorders. The term "thromboembolic disorders" as used herein includes conditions involving platelet activation and aggregation, such as arterial or venous cardiovascular or cerebrovascular thromboembolic disorders, including, for example, thrombosis, unstable angina, first or recurrent myocardial infarction, ischemic sudden death, transient ischemic attack, stroke, atherosclerosis, venous thrombosis, deep vein thrombosis, thrombophlebitis, arterial embolism, coronary and cerebral arterial thrombosis, myocardial infarction, cerebral embolism, kidney embolisms, pulmonary embolisms, or such disorders associated with diabetes, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I described above. The compounds of Formula I of the present invention may be useful for the treatment or prevention of other diseases which involve cell adhesion processes, including, but not limited to, infanimation, bone degradation, rheumatoid arthritis, asthma, allergies, adult respiratory distress syndrome, graft versus host disease, organ transplantation rejection, septic shock, psoriasis, eczema, contact dermatitis, osteoporosis, osteoarthritis, atherosclerosis, tumors, metastasis, diabetic retinopathy, inflammatory bowel disease and other autoimmune diseases. The compounds of Formula I of the present invention may also be useful for wound healing. The compounds of the present invention are useful for inhibiting the binding of fibrinogen to blood platelets, inhibiting aggregation of blood platelets, treating thrombus formation or embolus formation, or preventing thrombus or embolus formation in a mammal. The compounds of the invention may be used as a medicament for blocking fibrinogen from acting at its receptor site in a mammal. Compounds of the invention may be administered to patients where prevention of thrombosis by inhibiting binding of fibrinogen to the platelet membrane glycoprotein complex Ilb/IIIa receptor is desired. They are useful in surgery on peripheral arteries (arterial grafts, carotid endarterectomy) and in cardiovascular surgery where manipulation of arteries and organs, and/or the interaction of platelets with artificial surfaces, leads to platelet aggregation and consumption, and where the aggregated platelets may form thrombi and thromboemboli. The compounds of the present invention may be administered to these surgical patients to prevent the formation of thrombi and thromboemboli. Extracorporeal circulation is routinely used during cardiovascular surgery in order to oxygenate blood. Platelets adhere to surfaces of the extracorporeal circuit. Adhesion is dependent on the interaction between GPIIb/IIIa on the platelet membranes and fibrinogen adsorbed to the surface of the extracorporeal circuit. Platelets released from artificial surfaces show impaired homeostatic function. The compounds of the invention may be administered to prevent such ex vivo adhesion. The compounds of the present invention may be used for other ex vivo applications to prevent cellular adhesion in biological samples. Other applications of these compounds include prevention of platelet thrombosis, thromboembolism, and reocclusion during and after thrombolytic therapy and prevention of platelet thrombosis, thromboembolism and reocclusion after angioplasty of coronary and other arteries and after coronary artery bypass procedures. The compounds of the present invention may also be used to prevent myocardial infarction. The compounds of the present invention are useful as thrombolytics for the treatment of thromboembolic disorders. The compounds of the present invention can also be administered in combination with one or more additional therapeutic agents select from: anti-coagulant or coagulation inhibitory agents, such as heparin or warfarin; anti-platelet or platelet inhibitory agents, such as aspirin, piroxicam, or ticlopidine; thrombin inhibitors such as boropeptides, hirudin or argatroban; or thrombolytic or fibrinolytic agents, such as plasminogen activators, anistreplase, urokinase, or streptokinase. The compounds of Formula I of the present invention can be administered in combination with one or more of the foregoing additional therapeutic agents, thereby to reduce the doses of each drug required to achieve the desired therapeutic effect. Thus, the combination treatment of the present invention permits the use of lower doses of each component, with reduced adverse, toxic effects of each component. A lower dosage minimizes the potential of side effects of the compounds, thereby providing an increased margin of safety relative to the margin of safety for each component when used as a single agent. Such combination therapies may be employed to achieve synergistic or additive therapeutic effects for the treatment of thromboembolic disorders. By "therapeutically effective amount" it is meant an amount of a compound of Formula I that when administered alone or in combination with an additional therapeutic agent to a cell or mammal is effective to prevent or ameliorate the thromboembolic disease condition or the progression of the disease. By "administered in combination" or "combination therapy" it is meant that the compound of Formula I and one or more additional therapeutic agents are administered concurrently to the mammal being treated. When administered in combination each component may be administered at the same time or sequentially in any order at different points in time. Thus, each component may be administered separately but sufficiently closely in time so as to provide the desired therapeutic effect. The term anti-coagulant agents (or coagulation inhibitory agents), as used herein, denotes agents that inhibit blood coagulation. Such agents include warfarin (available as Coumadin™) and heparin. The term anti-platelet agents (or platelet inhibitory agents), as used herein, denotes agents that inhibit platelet function such as by inhibiting the aggregation, adhesion or granular secretion of platelets. Such agents include the various known non-steroidal anti-inflammatory drugs (NSAIDS) such as aspirin, ibuprofen, naproxen, sulindac, indomethacin, mefenamate, droxicam, diclofenac, sulfinpyrazone, and piroxicam, including pharmaceutically acceptable salts or prodrugs thereof. Of the NSAIDS, aspirin (acetylsalicyclic acid or ASA) , and piroxicam. Piroxicam is commercially available from Pfizer Inc. (New York, NY) , as Feldane TM. Other suitable anti-platelet agents include ticlopidine, including pharmaceutically acceptable salts or prodrugs thereof. Ticlopidine is also a preferred compound since it is known to be gentle on the gastro-intestinal tract in use. Still other suitable platelet inhibitory agents include thromboxane-A2-receptor antagonists and thromboxane-A2-synthetase inhibitors, as well as pharmaceutically acceptable salts or prodrugs thereof. The phrase thrombin inhibitors (or anti-thrombin agents) , as used herein, denotes inhibitors of the serine protease thrombin and other inhibitors of thrombin synthesis such as Factor XA. By inhibiting thrombin, various thrombin-mediated processes, such as thrombin-mediated platelet activation (that is, for example, the aggregation of platelets, and/or the granular secretion of plasminogen activator inhibitor-1 and/or serotonin) and/or fibrin formation are disrupted. Such inhibitors include boroarginine derivatives and boropeptides, hirudin and argatroban, including pharmaceutically acceptable salts and prodrugs thereof. Boroarginine derivatives and boropeptides include N-acetyl and peptide derivatives of boronic acid, such as C- terminal Ct-aminoborohic acid derivatives of lysine, omithine, arginine, homoarginine and corresponding isothiouronium analogs thereof. The term hirudin, as used herein, includes suitable derivatives or analogs of hirudin, referred to herein as hirulogs, such as disulfatohirudin. Boropeptide thrombin inhibitors include compounds described in Kettner et al., U.S. Patent No. 5,187,157 and European Patent Application Publication Number 293 881 A2, the disclosures of which are hereby incorporated herein by reference. Other suitable boroarginine derivatives and boropeptide thrombin inhibitors include those disclosed in PCT Application Publication Number 92/07869 and European Patent Application Publication Number 471 651 A2, the disclosures of which are hereby incorporated herein by reference, in their entirety. The phrase thrombolytics (or fibrinolytic) agents (or thrombolytics or fibrinolytics) , as used herein, denotes agents that lyse blood clots (thrombi) . Such agents include tissue plasminogen activator, anistreplase, urokinase or streptokinase, including pharmaceutically acceptable salts or prodrugs thereof. Tissue plasminogen activator (tPA) is commercially available from Genentech Inc., South San Francisco, California. The term anistreplase, as used herein, refers to anisoylated plasminogen streptokinase activator complex, as described, for example, in European Patent Application No. 028,489, the disclosures of which are hereby incorporated herein by reference herein, in their entirety. Anistreplase is commercially available as Eminase™. The term urokinase, as used herein, is intended to denote both dual and single chain urokinase, the latter also being referred to herein as prourokinase. Administration of the compounds of Formula I of the invention in combination with such additional therapeutic agent, may afford an efficacy advantage over the compounds and agents alone, and may do so while permitting the use of lower doses of each. A lower dosage minimizes the potential of side effects, thereby providing an increased margin of safety. GPIIb/IIIa is known to be overexpressed in metastatic tumor cells. The compounds or combination products of the present invention may also be useful for the treatment, including prevention, of metastatic cancer. The compounds of the present invention are also useful as standard or reference compounds, for example as a quality standard or control, in tests or assays involving the binding of fibrinogen to platelet GPIIb/IIIa. Such compounds may be provided in a commercial kit, for example, for use in pharmaceutical research involving GPIIb/IIIa. The compounds of the present invention may also be used in diagnostic assays involving platelet GPIIb/IIIa. The compounds herein described may have asymmetric centers. Unless otherwise indicated, all chiral, diastereomeric and racemic forms are included in the present invention. Many geometric isomers of olefins, C=N double bonds, and the like can also be present in the compounds described herein, and all such stable isomers are contemplated in the present invention. It will be appreciated that compounds of the present invention that contain asymmetrically substituted carbon atoms may be isolated in optically active or racemic forms. It is well known in the art how to prepare optically active forms, such as by resolution of racemic forms or by synthesis, from optically active starting materials. All chiral, diastereomeric, racemic forms and all geometric isomeric forms of a structure are intended, unless the specific stereochemistry or isomer form is specifically indicated. When any variable (for example but not limited to, R 2 , R 4 , R 6 , R 7 , R 8 , R 12 ,and R 14 , n, etc.) occurs more than one time in any constituent or in any formula, its definition on each occurrence is independent of its definition at every other occurrence. Thus, for example, if a group is shown to be substituted with 0-2 R 4 , then said group may optionally be substituted with up to two R 4 and R 4 at each occurrence is selected independently from the defined list of possible R 4 . Also, by way of example, for the group -N(R 5a ) 2 , each of the two R 5 substituents on N is independently selected from the defined list of possible R 5 . Similarly, by way of example, for the group -C(R 7 ) 2 -/ each of the two R 7 substituents on C is independently selected from the defined list of possible R 7 . When a bond to a substituent is shown to cross the bond connecting two atoms in a ring, then such substituent may be bonded to any atom on the ring. When a bond joining a substituent to another group is not specifically shown or the atom in such other group to which the bond joins is not specifically shown, then such substituent may form a bond with any atom on such other group. When a substituent is listed without indicating the atom via which such substituent is bonded to the rest of the compound of Formula I, then such substituent may be bonded via any atom in such substituent. For example, when the substituent is piperazinyl, piperidinyl, or tetrazolyl, unless specified otherwise, said piperazinyl, piperidinyl, tetrazolyl group may be bonded to the rest of the compound of Formula I via any atom in such piperazinyl, piperidinyl, tetrazolyl group. Combinations of substituents and/or variables are permissible only if such combinations result in stable compounds. By stable compound or stable structure it is meant herein a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into an efficacious therapeutic agent. The term "substituted", as used herein, means that any one or more hydrogen on the designated atom is replaced with a selection from the indicated group, provided that the designated atom's normal valency is not exceeded, and that the substitution results in a stable compound. When a substitent is keto (i.e., =0), then 2 hydrogens on the atom are replaced. As used herein, "alkyl" is intended to include both branched and straight-chain saturated aliphatic hydrocarbon groups having the specified number of carbon atoms (for example, "Ci-Cio" denotes alkyl having 1 to 10 carbon atoms); "haloalkyl" is intended to include both branched and straight-chain saturated aliphatic hydrocarbon groups having the specified number of carbon atoms, substituted with 1 or more halogen (for example -C V F W where v = 1 to 3 and w = 1 to (2v+l) ) ; "alkoxy" represents an alkyl group of indicated number of carbon atoms attached through an oxygen bridge; "cycloalkyl" is intended to include saturated ring groups, including mono- , bi-, or poly-cyclic ring systems, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, and adamantyl; and "bicycloalkyl" is intended to include saturated bicyclic ring groups such as [3.3.0]bicyclooctane, [4.3.0]bicyclononane, [4.4.0]bicyclodecane (decalin) , [2.2.2]bicyclooctane, and so forth. "Alkenyl" is intended to include hydrocarbon chains of either a straight or branched configuration and one or more unsaturated carbon-carbon bonds which may occur in any stable point along the chain, such as ethenyl, propenyl and the like; and "alkynyl" is intended to include hydrocarbon chains of either a straight or branched configuration and one or more triple carbon- carbon bonds which may occur in any stable point along the chain, such as ethynyl, propynyl and the like. The terms "alkylene", "alkenylene", "phenylene", and the like, refer to alkyl, alkenyl, and phenyl groups, respectively, which are connected by two bonds to the rest of the structure of Formula I. Such "alkylene", "alkenylene", "phenylene", and the like, may alternatively and equivalently be denoted herein as "-(alkyl)-", "-(alkenyl)-" and "-(phenyl)-", and the like. "Halo" or "halogen" as used herein refers to fluoro, chloro, bromo and iodo; and "counterion" is used to represent a small, negatively charged species such as chloride, bromide, hydroxide, acetate, sulfate and the like. As used herein, "aryl" or "aromatic residue" is intended to mean phenyl or naphthyl optionally substituted with 0-3 groups independently selected from methyl, methoxy, amino, hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; the term "arylalkyl" represents an aryl group attached through an alkyl bridge. As used herein, "carbocycle" or "carbocyclic residue" is intended to mean any stable 3- to 7- membered monocyclic or bicyclic or 7- to 14-membered bicyclic or tricyclic or an up to 26-membered polycyclic carbon ring, any of which may be saturated, partially unsaturated, or aromatic. Examples of such carbocyles include, but are not limited to, cyclopropyl, cyclopentyl, cyclohexyl, phenyl, biphenyl, naphthyl, indanyl, adamantyl, or tetrahydronaphthyl (tetralin) . As used herein, the term "heterocycle" or "heterocyclic" is intended to mean a stable 5- to 7- membered monocyclic or bicyclic or 7- to 10-membered bicyclic heterocyclic ring which may be saturated, partially unsaturated, or aromatic, and which consists of carbon atoms and from 1 to 4 heteroatoms independently selected from the group consisting of N, 0 and S and wherein the nitrogen and sulfur heteroatoms may optionally be oxidized, and the nitrogen may optionally be quaternized, and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring. The heterocyclic ring may be attached to its pendant group at any heteroatom or carbon atom which results in a stable structure. The heterocyclic rings described herein may be substituted on carbon or on a nitrogen atom if the resulting compound is stable. Examples of such heterocycles include, but are not limited to, pyridyl (pyridinyl), pyrimidinyl, furanyl (furyl), thiazolyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, tetrazolyl, benzofuranyl, benzothiophenyl, indolyl, indolenyl, isoxazolinyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, 4-piperidonyl, pyrrolidinyl, 2-pyrrolidonyl, pyrrolinyl, tetrahydrofuranyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, decahydroquinolinyl or octahydroisoquinolinyl, azocinyl, triazinyl, 6H-l,2,5-thiadiazinyl, 2H, 6H-1 ,5,2-dithiazinyl, thianthrenyl, pyranyl, isobenzofuranyl, chromenyl, xanthenyl, phenoxathiinyl, 2H-pyrrolyl, pyrrolyl, imidazolyl, pyrazolyl, isothiazolyl, isoxazolyl, oxazolyl, pyrazinyl, pyridazinyl, indolizinyl, isoindolyl, 3H- indolyl, lH-indazolyl, purinyl, 4H-quinolizinyl, phthalazinyl, naphthyridinyl, quinoxalinyl, quinazolinyl, cinnolinyl, pteridiny1, 4aff-carbazole, carbazole, β-carbolinyl, phenanthridinyl, acridinyl, perimidinyl, phenanthrolinyl, phenazinyl, phenarsazinyl, phenothiazinyl, furazanyl, phenoxazinyl, isochromanyl, chromanyl, imidazolidinyl, imidazolinyl, pyrazolidiny1, pyrazolinyl, piperazinyl, indolinyl, isoindolinyl, quinuc1idiny1, morpholinyl or oxazolidinyl. Also included are fused ring and spiro compounds containing, for example, the above heterocycles. As used herein, the term "heteroaryl" refers to aromatic heterocyclic groups. Such heteroaryl groups are preferably 5-6 membered monocylic groups or 8-10 membered fused bicyclic groups. Examples of such heteroaryl groups include, but are not limited to pyridyl (pyridinyl) , pyrimidinyl, furanyl (furyl), thiazolyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, indolyl, isoxazolyl, oxazolyl, pyrazinyl, pyridazinyl, benzofuranyl, benzothienyl, benzimidazolyl, quinolinyl, or isoquinolinyl. As used herein, the term "chiral amine" refers to any amine containing compound that also contains a chiral center. Such compounds include, by way of example and without limitation, either enantiomer of cinchonidine, ephedrine, 2-phenylglycinol, 2-amino-3-methoxy-l-propanol, quinidine and pseudoephedrine. As used herein, "pharmaceutically acceptable salts" refer to derivatives of the disclosed compounds wherein the parent compound of Formula I is modified by making acid or base salts of the compound of Formula I. Examples of pharmaceutically acceptable salts include, but are not limited to, mineral or organic acid salts of basic residues such as amines; alkali or organic salts of acidic residues such as carboxylic acids; and the like. "Prodrugs" are considered to be any covalently bonded carriers which release the active parent drug according to Formula I in vivo when such prodrug is administered to a mammalian subject. Prodrugs of the compounds of Formula I are prepared by modifying functional groups present in the compounds in such a way that the modifications are cleaved, either in routine manipulation or in vivo, to the parent compounds. Prodrugs include compounds of Formula I wherein hydroxyl, amino, sulfhydryl, or carboxyl groups are bonded to any group that, when administered to a mammalian subject, cleaves to form a free hydroxyl, amino, sulfhydryl, or carboxyl group respectively. Examples of prodrugs include, but are not limited to, acetate, formate and benzoate derivatives of alcohol and amine functional groups in the compounds of Formula I, and the like. Examples of representative carboxyl and amino prodrugs are included under the definition of R 2 , R 3 , and Y. The pharmaceutically acceptable salts of the compounds of Formula I include the conventional non-toxic salts or the quaternary ammonium salts of the compounds of Formula I formed, for example, from non-toxic inorganic or organic acids. For example, such conventional non-toxic salts include those derived from inorganic acids such as hydrochloric, hydrobromic, sulfuric, sulfamic, phosphoric, nitric and the like; and the salts prepared from organic acids such as acetic, propionic, succinic, glycolic, stearic, lactic, malic, tartaric, citric, ascorbic, pamoic, maleic, hydroxymaleic, phenylacetic, glutamic, benzoic, salicylic, sulfanilic, 2-acetoxybenzoic, fumaric, toluenesulfonic, methanesulfonic, ethane disulfonic, oxalic, isethionic, and the like. The pharmaceutically acceptable salts of the present invention can be synthesized from the compounds of Formula I which contain a basic or acidic moiety by conventional chemical methods. Generally, the salts are prepared by reacting the free base or acid with stoichiometric amounts or with an excess of the desired salt-forming inorganic or organic acid or base in a suitable solvent or various combinations of solvents. The pharmaceutically acceptable salts of the acids of Formula I with an appropriate amount of a base, such as an alkali or alkaline earth metal hydroxide e.g. sodium, potassium, lithium, calcium, or magnesium, or an organic base such as an amine, e.g., dibenzylethylenediamine, trimethylamine, piperidine, pyrrolidine, benzylamine and the like, or a quaternary ammonium hydroxide such as tetramethylammoinum hydroxide and the like. As discussed above, pharmaceutically acceptable salts of the compounds of the invention can be prepared by reacting the free acid or base forms of these compounds with a stoichiometric amount of the appropriate base or acid, respectively, in water or in an organic solvent, or in a mixture of the two; generally, nonaqueous media like ether, ethyl acetate, ethanol, isopropanol, or acetonitrile are preferred. Lists of suitable salts are found in Remington's Pharmaceutical Sciences. 17th ed. , Mack Publishing Company, Easton, PA, 1985, p. 1418, the disclosure of which is hereby incorporated by reference. The disclosures of all of the references cited herein are hereby incorporated herein by reference in their entirety. Synthesis The compounds of the present invention can be prepared in a number of ways well known to one skilled in the art of organic synthesis. The compounds of the present invention can be synthesized using the methods described below, together with synthetic methods known in the art of synthetic organic chemistry, or variations thereon as appreciated by those skilled in the art. Preferred methods include, but are not limited to, those described in PCT Patent Application International Publication Number WO 95/14683 and the methods described below. All references cited herein are hereby incorporated in their entirety herein by reference. The following abbreviations are used herein: 0-Ala 3-aminopropionic acid Boc te -butyloxycarbonyl Boc 2 Q di-tert-butyl dicarbonate BOP benzotriazolyl-N-oxytris(dimethylamino)- phosphonium hexafluorophosphate BSTFA N,O-bis(trimethylsilyl)trifluoromethyl- acetamide Cbz benzyloxycarbonyl DCC 1,3-dicyclohexylcarbodiimide DEAD diethyl azodicarboxylate DEC 1-(3-dimethylaminopropyl)-3- ethylcarbodiimide hydrochloride DIEA diisopropylethylamlne DCHA dicyclohexylamine DCM dichloromethane DMAP 4-dimethylaminopyridine DMF N,iV-dimethylformamide EtOAc ethyl acetate EtOH ethyl alcohol HOBt 1-hydroxybenzotriazole IBCF iso-butyl chloroformate LAH lithium aluminum hydride NCS iV-chlorosuccinimide NMM -methylmorpholine PPh3 triphenylphosphine pyr pyridine TBTU 2-(lH-Benzotriazol-1-yl)-1,1,3,3- tetramethyluronium tetrafluoroborate TFA trifluoroacetic acid THF tetrahydrofuran A convenient method for the synthesis of the compounds of this invention utilizes a dipolar cycioaddition of nitrile oxides with appropriate dipolarophiles to prepare the isoxazoline rings present in compounds of Formula I (for reviews of 1,3-dipolar cycioaddition chemistry, see 1,3-Dipolar Cycioaddition Chemistry (Padwa, ed.), Wiley, New York, 1984; Kanemasa and Tsuge, Heterocycles 1990, 3_0_, 719). Scheme I describes one synthetic sequence to the compounds of the second embodiment of this invention. An appropriately substituted hydroxylamine is treated with NCS in DMF according to the method of Liu, et al. (J. Orσ. Chem. 1980, 15_, 3916). The resulting hydroxi inoyl chloride is then dehydrohalogenated in situ using TEA to give a nitrile oxide, which undergoes a 1,3-dipolar cycioaddition to a suitably substituted alkene to afford the isoxazoline. Alternatively, the oxime may be oxidatively chlorinated, dehydrochlorinated and the resulting nitrile oxide trapped by a suitable alkene under phase transfer conditions according to the method of Lee (Synthesis 1982, 508) . Hydrolysis of the ester using conventional methods known to one skilled in the art of organic synthesis gives the desired acids. Intermediates containing alkali-sensitive functionality, such as nitrile, may be deesterified with excellent chemoselectivity using sodium trimethylsilanolate according to the procedure of Laganis and Ehenard (Tetrahedron Lett. 1984, 25., 5831). Coupling of the resulting acids to an appropriately substituted a- or β- amino ester using standard coupling reagents, such as DCC/HOBt, affords a nitrile-amide. The nitrile is then converted to the amidine via the imidate or thioimidate under standard conditions followed by ester saponification (LiOH, THF/H 2 0) . Scheme I 3) LiOH, THF (aq) An example of a related method of preparation for compounds within the second embodiment of the present invention is illustrated in Scheme la. Conversion of 3- (4-cyanophenyl)isoxazolin-5-ylacetic acid to the corresponding amidine, followed by protection as the Boc- derivative and saponification provides 3-(4-Boc- amidinophenyl)isoxazolin-5-ylacetic acid which is coupled with β-amino acid esters as shown. Deprotection provides the desired isoxazolinylacetyl-β-aminoalaninyl esters. Saponification as described above gives the free acids, Scheme la A further example of the synthesis of compounds within the second embodiment is shown in Scheme lb. Cycioaddition of commerically available 4-cyanostyrene and t-butyl-3-oxoproprionate oxime using the method described by Gree et al. (Bioorganic and Med. Chem. Lett. 1994, 253) provides t-butyl [5- (4-cyanophenyl) isoxazolin-3- yl]acetate. Using the procedures described above, this intermediate is converted to compounds of formula I wherein the isoxazoline ring is in the reverse orientation with respect to the compounds prepared via Schemes I and la. -Ill- Scheme lb 3. TFA Additional isoxazolinyl acetates useful as starting materials for the preparation of compounds of Formula I, wherein V is -(phenyl)-Q- and Q is other than a single bond, can be prepared by cycioaddition of a suitably substituted chloro or bromooxime with an ester of vinyl acetic acid as shown in Scheme Ic using literature methods or modifications thereof. (D. P. Curran & J. Chao, J. Org. Chem. 1988, 53, 5369-71; J. N. Kim & E. K. Ryu, Heterocycles 1990, 31, 1693-97). Scheme Ic Q=S(0)o- 2 , O R=Ph or Et The compounds of the present invention where R 2 or R 3 is e.g. alkoxycarbonyl may be prepared by reacting the free amidines, amines or guanidines with an activated carbonyl derivative, such as an alkyl chloroformate. In compounds of the second embodiment, the conversion of the free amines, amidines and guanidines to such acyl-nitrogen groups may optionally be performed prior to coupling an isoxazoline acetic acid with e.g β-amino acids, as illustrated in Scheme la. The compounds of the present invention wherein Y is an oxyalkoxy group, e.g. alkoxycarbonyloxyalkoxy, may be prepared by reacting a suitably protected carboxylic acid of Formula I with an alkoxycarbonyloxyalkyl chloride in the presence of an iodide source, such as tetrabutylammonium iodide or potassium iodide, and an acid scavenger, such as triethylamine or potassium carbonate, using procedures known to those skilled in the art. The appropriately substituted racemic β-amino acids may be purchased commercially or, as is shown in Scheme II, Method 1, prepared from the appropriate aldehyde, malonic acid and ammonium acetate according to the procedure of Johnson and Livak (J. Am. Chem. Soc. 1936, 58. 299) . Racemic β-substituted-β-amino esters may be prepared through the reaction of dialkylcuprates or alkyllithiums with 4-benzoyloxy-2-azetidinone followed by treatment with anhydrous acid in ethanol (Scheme I, Method 2) or by reductive amination of β-keto esters as is described in WO9316038. (Also see Rico et al., J. Org. Chem. 1993, 53., 7948-51.) Enantiomerically pure β- substituted-β-amino acids can be obtained through the optical resolution of the racemic mixture or can be prepared using numerous methods, including: Arndt-Eistert homologation of the corresponding α-amino acids as shown in Scheme II, Method 3 (see Meier, and Zeller, Anσew. Chem. int. Ed. Enσl. 1975, H, 32; Rodriguez, et al. Tetrahedron Lett. 1990, .21, 5153; Greenlee, J, Med, hem. 1985, 2ϋ# 434 and references cited within); and through an enantioselective hydrogenation of a dehydroamino acid as is shown in Scheme II, Method 4 (see Asymmetric Synthesis, Vol. 5, (Morrison, ed. ) Academic Press, New York, 1985). A comprehensive treatise on the preparation of β-amino acid derivatives may be found in patent application WO 9307867, the disclosure of which is hereby incorporated by reference. Sc eme ix Method 1 COjMe Method 2 Method 3 Method 4 The synthesis of N 2 -substituted diaminopropionic acid derivatives can be carried out via Hoffman rearrangement of a wide variety of asparagine derivatives as described in Synthesis, 266-267, (1981). The appropriately substituted pyrrolidine-, piperidine- and hexahydroazepineacetic acids may be prepared using a number of methods. The pyrrolidines are conveniently prepared using an Arndt-Eistert homologation of the corresponding proline as shown in Scheme III, Method 1 (see Meier, and Zeller, Anσew. Chem. Int. Ed. Enσl. 1975, 2A, 32; Rodriguez, et al. Tetrahedron Lett. 1990, 11, 5153; Greenlee, J. Med. Chem. 1985, 23., 434 and references cited within) . The piperidines can be prepared by reduction of the corresponding pyridine as shown in Scheme III, Method 2. The hexahydroazepines are prepared by reduction of the corresponding vinylogous amide using sodium cyanoborohydride as depicted in Scheme III , Method 3 . Scheme III Method 1 „ .. COM 1) 'BCF, NMM 1) Ag + , MeOH Method 2 Method 3 Many additional appropriately substituted heterocycles are available commercially or can be readily modified by procedures known by one skilled in the art. Appropriately substituted morpholines can be prepared from amino acids via the sequence of steps depicted in Scheme Ilia, method Ksee Brown, et. al. J. Chem. Soc. Perkin Trans I 1987, 547; Bettoni, et. al. Tetrahedron 1980, 36, 409; Clarke, F.H. J " . Org. Chem. 1962, 27, 3251 and references therein.) N-ethoxycarbonylmethyl-1,2- diazaheterocyles are prepared by condensation of suitably substituted dibromides with benzylhydrazine followed by Mitsunobu reaction with ethyl hydroxyacetate and deprotection as shown in Scheme Ilia, method 2 (see Kornet, et. al. J. Pharm. Sci. 1979, 68, 377.; Barcza, et. al. J. Org. Chem. 1976, 41, 1244 and references therein.) Scheme II I a Method 1 BH,-SMe 2 THF HzO MeOH Method 2 COjEt A general synthetic protocol to the compounds of the first embodiment of this invention is depicted in Scheme IV. Coupling of a suitable Boc-protected amino alcohol to an appropriately substituted phenol under Mitsunobu conditions (see Mitsunobu, Synthesis 1981, 1) is followed by oximation using hydroxylamine hydrochloride in 1:1 ethanol/pyridine. Isoxazoline formation, ester saponification and Boc-deprotection (33% TFA/DCM) then affords the compounds of this invention in good overall yield. Scheme IV The synthesis of the spiro-fused isoxazolinyl imides of the third embodiment of the present invention is exemplified by the general protocol depicted in Scheme V. Dipolar cycioaddition of an oximinoyl chloride with a a- methylene diester affords an isoxazolinyl diester, which is deesterified using the silanolate method. Dehydration to the anhydride according to Ishihara, et al. (Chem. Pharm. Bull. 1992, , 1177-85) followed by imide formation using an appropriately substituted amino ester affords the spirocycle. Alternatively, the imide may be prepared directly from the isoxazoline diester according to Culbertson, et al. (J. Med. Chem. 1990, _2_, 2270-75). Amidine formation or Boc deprotection followed by ester saponification then affords the compounds of this invention in good overall yield. Scheme V The synthesis of the spiro-fused isoxazolinyl amides of the third embodiment of the present invention is exemplified by the general protocol depicted in Scheme VI. Dipolar cycioaddition of an oximinoyl chloride with a - methylene lactone affords the isoxazolinyl lactone, which is reacted with an appropriate amino ester to afford the amide (see The Chemistry of the Amides (Zabicky, ed. ) , p 96, Interscience, New York, 1970; Prelog, et al., Helv. Chim. Acta 1959, 2, 1301; Inubushi, et al. , J. Chem. Soc.. Chem. Commun. 1972, 1252) . Amidine formation or Boc deprotection followed by ester saponification then affords the compounds of this invention in good overall yield. Sςheme VI The synthesis of the spiro-fused isoxazolinyl cycloalkenes of the third embodiment of the present invention is exemplified by the general protocol depicted in Scheme VII. Dipolar cycioaddition of an oximinoyl chloride with an appropriately substituted α-methylene lactone affords the isoxazolinyl lactone. The lactone is then reacted with an appropriate lithium dimethyl alkylphosphonate, followed by PCC oxidation. The resulting diketophosphonate undergoes an intramolecular Wittig reaction in the presence of K 2 Cθ 3 /18-crown-6 according to the method described by Lim and Marquez (Tetrahedron Lett. 1983, 24. 5559) . Amidine formation or Boc deprotection followed by ester saponification then affords the compounds of this invention in good overall yield. Scheme VII The dipolarophiles used to prepare the compounds of this invention may be prepared by numerous methods. The ω-alkenoic ester class of dipolarophile may be purchased commercially or prepared by oxidation of the corresponding ω-alkenols by the method of Corey and Schmidt (Tetrahedron Lett. 1979, 399, Scheme VIII, Method 1). The α-methylene diester and α-methylene lactone class of dipolarophile may be purchased commercially or can be prepared by numerous methods from the corresponding diester (see Osbond, it. Chem. Soc. 1951, 3464; Ames and Davey, J. Chem. Soc. 1958, 1794; Vig, et al., Ind. J. Chem. 1968, £, 60; Grieco and Hiroi, J. Chem. Soc. Chem. Commun. 1972, 1317, Scheme VIII, Method 2). The 3- (styryl)propionic ester class of dipolarophile may be prepared by palladium-catalyzed cross coupling of the appropriately substituted bromo- or iodohydrocinnamic acid to a vinylmetal species according to methods cited within Mitchell (Synthesis 1992, 803) and Stille (Anσew. Chem. Int. Ed. Enσl. 1986, 25_, 508, Scheme VIII, Method 3) . Scheme VIH Method 1 Method s Compounds of Formula I wherein b is a double bond can be prepared using one of the routes depicted in Scheme IX. Bromination followed by subsequent dehydrobromination of a suitably substituted methyl 3-(cyanophenyl)isoxazolin-5- ylacetate, prepared as described above, using the method of Elkasaby & Salem (Indian J. Chem. 1980, 19B, 571-575) provides the corresponding isoxazole intermediate. Alternately, this intermediate can be obtained by 1,3- dipolar cycioaddition of a cyanophenylnitrile oxide (prepared from the corresponding chlorooxime as described in Scheme I) with an appropriate alkyne to give the isoxazole directly. Hydrolysis of the ester using conventional methods known to one skilled in the art of organic synthesis gives the acetic acids. Coupling of the resulting acids to an appropriately substituted α- or β- amino ester using standard coupling reagents, such as TBTU, affords a nitrile-amide. The nitrile is then converted to the amidine via the imidate or thioimidate under standard conditions to give the prodrug esters. Saponification gives the acids. Scheme IX Compounds of Formula I wherein R 1 is (R 2 ) (R 3 )N(R 2 N=)CN(R 2 )- and V is phenylene are prepared as illustrated in Scheme X. Cycioaddition of an appropriately N-protected aminophenylaldoxime with vinyl acetic acid, t-butyl ester, using the conditions described above provides t-butyl [3-(4-t- butyloxycarbonylaminophenyl)isoxazolin-5-yl]acetate. Hydrolysis of the ester with lithium hydroxide provides the free acid which can be coupled with a suitably substituted methyl 3-aminopropionate as previously described. After deprotection, the aniline is converted to the corresponding guanidine using the method described by Kim et al. (Tetrahedron Lett. 1993, 48, 7677). A final deprotection step to remove the BOC groups provides guanidino compounds of Formula I. Scheme X BOC TBTU/Et 3 N EtOAc or DMF An example of the preparation of compounds of the second embodiment wherein Rl-U is a benzamide is illustrated in Scheme XI. Conversion of the 3-(4- cyanophenyl)isoxazolin-5-yl-β-aminoalaninyl esters to the amides can be accomplished by reaction of the nitrile with an appropriate alcohol under acidic conditions. (J. Med. Chem. 1991, 34, 851.) The substituted amides can be accessed by allowing the 3-(4-cyanophenyl)isoxazolin-5-yl- β-aminoalaninyl esters to react with an appropriate halogenated compound (Synthesis, 1978, 303. Saponification as described above gives the free acids. Scheme XI The compounds of the invention where U is a pyridyl may be prepared by several methods. 2-Amino-4-pyridyl analogs can be easily accessed from readily available 2- bromo-4-pyridylcarboxaldehyde (Corey, E.J et. al. Tetrahedron Lett. 1983, 32, 3291). The desired amino compound can be suitably introduced by displacement of the bromo substituent with a suitable ammonia source or alternatively with sodium azide followed by reduction via standard techniques known to those in the art. 2-Amidino- 5-pyridyl analogs can be accessed from 2-bromo-5- pyridylcarboxaldehyde by displacement of the bromide at an appropriate stage in the synthesis with KCN. Conversion of the nitrile to the requisite amidine then affords the desired products. 6-Amino-3-pyridyl analogs can be easily accessed (according to the method described for the preparation of 2-amino-5-pyridyl analogs) from 6-chloro-3- pyridylcarboxaldehyde. This was obtained in part from 6- chloro-3-pyridylcarboxylic acid (Aldrich) via techinques known in the art. 6-Amidino-3-pyridyl analogs can be readily accessed from 6-chloro-3-pyridylcarboxaldehyde via techniques described for 2-amidino-5-pyridylanalogs. The preparation of quinuclidine carboxaldehyde starting materials may be done as follows. 4-Cyanoquinuclidine prepared by the method of Kanai,T. et al, (Het., 1992, 2A, 2137), can be converted to quinuclidine-4-carboxaldehyde by standard conditions and homologated by the method of (Tetrahedron Lett. 1987, 38. 1847) to the desired aldehyde. Conversion of the aldehyde to the oxime followed by chlorination to the chlorooxime should then afford the key quinuclidine chlorooxime which can then be further elaborated to the desired compounds. The synthesis of spiro-fused isoxazolinyl amines of the third embodiment of the present invention is exemplified by the general protocol depicted in Scheme XII. Dipolar cycioaddition of a suitable oxime with a suitably protected methylenecycloamine, prepared by methods known in the literature (De Amici, M. ; Frølund, B.; Hjeds, H.; Krogsgaard-Larson, P. Eur. J. Med. Chem. 1991, 26, 625; Mimura, M. , et. al . Chem. Pharm. Bull . 1993, 41 , 1971; Labouta, I. M. ; Jacobsen, P.; Thorbek, P Krogsgaard-Larson, P.; Hjeds, H. Acta Chem. Scand. , Ser. B 1982, 36, 669), yields the spirocyclic amine after deprotection. This amine can be functionalized with a serine beta-lactone (Arnold, L. D.; Kalantar, T. H.; Vederas, J. C. J. Am. Chem. Soc. 1985, 107, 7105) providing an optically active product. Alternatively, the amine can be reacted with a 3-iodo or 3-chloroalanine derivative (I: Marki, W. ; Schwyzer, R. Helv. Chim. Acta 1975, 58, 1471; Cl: Bigge, C. F.; Wu J.-P.; Drummond, J. R. Tetrahedron Lett . 1991, 32, 7659; Benoiton, L. Can . J. Chem. 1968, 46, 1549) to give a racemic product. Scheme XII . r R ϊ V 2. hydrolysis The cycioaddition can also be performed after the introduction of the propionyl side chain as shown in Scheme XIII. Scheme XIII , The compounds of Tables 12 and 13 were made using combinatorial synthetic methodology as shown in Scheme XIV. Thus, a resin was derivatized and to it was coupled the protected 2,3-diaminoproprionate. Following deprotection of N 3 , the desired isoxazoline carboxylic acid was coupled to N 3 . The final product was removed from once the terminal amine of the isoxazoline carboxylic acid was converted to its desired form. Scheme XIV. 5 eg. 5 eq. 1) 20% piperidine/DMF \ (2) T 2 :CH ^' 2 (1 :1) \ 2 equiv. DIEA/DMF 3) TFAiCHjClg (1:1) • Can also be: FMocHN m " V // ' nlf O— N 0 The compounds of this invention and their preparation can be further understood by the following procedures and examples, which exemplify but do not constitute a limit of their invention. Example 43 N- \3 - ( -Amidinonhenvl)isoxazolin-5 (R. S)- vlacetvl1-(i?.ff)-3-amino-3-phenvlnronanoic Acid Part A: 4-Cvanobenzaldoxime This material was prepared from 4-cyanobenzaldehyde according to Kawase and Kikugawa (J. Chem. Soc. Perkin Trans I 1979, 643). To a solution of 4-cyanobenzaldehyde (1.31 g, 10 mmol) in 1 : 1 EtOH : pyridine (10 mL) was added hydroxylamine hydrochloride (0.70 g, 10 mmol). The resulting solution was stirred at room temperature for 18 h and was concentrated in vacuo to one-half volume. To this solution was added ice water, causing the product to crystallize from solution. Recrystallization from EtOH - water followed by drying over P 2 O 5 afforded 1.46 g (100%) of the desired oxime; mp: 167.8-169.4 'C. Part B: Methvl 3-(3-Butenovl)amino-3-phenvlpropionate To a solution of vinylacetic acid (861 mg, 10.0 mmol) , methyl 3-amino-3-phenylpropionate hydrochloride (2.37 g, 11.0 mmol) and TEA (1.6 mL, 12 mmol) in DCM (20 mL) at -10 * C was added DEC (2.11 g, 11.0 mmol). The resulting mixture was stirred at -10 'C for 15 hours. The mixture was then washed with water, 0.1 M HCI, sat. NaHCθ 3 , sat. NaCl and dried over anhydrous MgSθ 4 - Concentration in vacuo followed by pumping until constant weight gave 2.36 g (95%) of the desired amide as a golden oil of suitable purity for further reaction; 1 H NMR (300 MHz, CDCI 3 ) 57.28 (m, 5H) , 6.78 (bd, J = 7.7 Hz, IH) , 5.95 (m, IH) , 5.43 (dt, J = 8.4, 5.9 Hz, IH) , 5.25 (m, 2H) , 3.61 (s, 3H) , 3.04 (d, J = 7.0 Hz, 2H) , 2.88 (dq, J = 15.0, 5.9 Hz, 2H) . Part C: Methyl 3 (R. S) -(5 JR. S)-N- \ 3 -(4- Cvanoohenvl)isoxazolin-5-vlacetvllamino)-3- phenvlpropanoate To a solution of methyl 3-(3-butenoyl)amino-3- phenylpropionate (816 mg, 3.30 mmol) and 4- cyanobenzaldoxime (prepared according to Example 1, Part A, 438 mg, 3.00 mmol) in CH 2 C1 2 (10 mL) was added a 5% solution of sodium hypochlorite ("Clorox", 5.3 mL, 3.5 mmol) . The resulting mixture was stirred rapidly overnight (15 h) , the layers separated and the aqueous washed with CH 2 CI 2 . The combined organic was dried (MgS04) and concentrated in vacuo . The crude product was then purified using flash chromatography (70% EtOAc/hexanes), affording 731 mg (62%) of the desired isoxazoline as a 1 : 1 mixture of diastereomers; 1 H NMR (300 MHz, CDCI 3 ) 57.74 (m, 8H) , 7.29 (m, 10H) , 6.92 (bm, 2H) , 5.42 (m, 2H) , 5.16 (m, 2H) , 3.64 (s, 3H) , 3.60 (s, 3H) , 3.48 (m, 2H) , 3.26 (dd, J = 17.3, 7.7 Hz, IH) , 3.15 (dd, J = 16.8, 8.1 Hz, IH) , 2.85 (m, 2H) , 2.69 (m, 2H) . Part D: Methyl 3 (R. S) -f5 (R. S)-N-T3-(4- Amidinophenvl)isoxazo-lin-5-vlacetvllamino)-3- phenylpropanoate Into a solution of methyl 3 (R, S)-{5 (R, S)-N-[3- (4- cyanophenyl)isoxazolin-5-ylacetyl]amino)-3- phenylpropanoate (587 mg, 1.50 mmol) in 10% DCM/methanol (55 mL) was bubbled dry HCI gas for 2 hours. The mixture was stirred for 18 hours, then concentrated in vacuo . The crude imidate was dissolved in methanol (20 mL) and ammonium carbonate added. The resulting mixture was stirred for 18 hours, then filtered. The filtrate was concentrated in vacuo and the residue purified using flash chromatography (CHCI3 - 20% methanol/CHCl3) . Concentration of the appropriate fractions in vacuo followed by placing the residue under vacuum until constant weight afforded 193 mg (32%) of the desired amidines; CIMS (NH 3 , e/z, relative abundance) : 409 (M + H) + , 100%. Part E: 3 (R. S) - ( 5 (R . S)-N-r3-(4-Amidinophenyl) isoxazolin- 5-vlacetvπamino)-3-phenvlpropanoic Acid. Trifluoroacetic Acid salt Methyl 3(Jl,S)-{5(Λ,S)-N-[3-(4- amidinophenyl)isoxazolin-5-ylacetyl]amino}-3- phenylpropanoate (45 mg, 0.113 mmol) was saponified using 0.5 M LiOH (0.6 mL, 0.3 mmol) according to Example 1, Part F, affording 28 mg (49%); CIMS (NH 3 , e/z, relative abundance): 412 (M + H)+, 100%. Example 43A 5 IR . S)-N-T3- (4-Amidinophenyl)isoxazolin-5- vlacetvll minopropanoic Acid Part A: Ethyl 3-( -Putenpyl)amjnopropionate To an ice cold solution of vinylacetic acid (4.39 g, 51.0 mmol), ethyl 3-aminopropionate hydrochloride (8.49 g, 55.3 mmol) and TEA (7.8 mL, 56 mmol) in DCM (50 mL) was added DEC (10.54 g, 55.0 mmol). The resulting mixture was warmed to room temperature overnight (18 h) . The mixture was then washed with water, 0.1 M HCI, sat. NaHCC> 3 , sat. NaCl and dried (MgSθ 4 ) . Concentration in vacuo followed by pumping until constant weight was achieved gave 6.34 g (67%) of the desired amide as a golden oil of purity suitable for further reaction; IH NMR (300 MHz, CDCI 3 ) 5 6.26 (bs, IH), 5.98-5.85 (m, IH) , 5.25-5.17 (m, 2H) , 4.16 (q, J = 7.0 Hz, 2H) , 3.52 (q, J = 5.9 Hz, 2H) , 2.99 (dt, J = 7.0, 1.1 Hz, 2H) , 2.53 (t, J = 5.9 Hz, 2H) , 1.27 (t, J = 7.0 Hz, 3H) . Part B: Ethvl 5 (R . S)-N- " 3-(4-Cvanophenvl)isoxazolin-5- vlacetvl1aminopropanoate To a solution of ethyl 3-(3-butenoyl)aminopropionate (556 mg, 3.00 mmol) and 4-cyanobenzaldoxime (prepared according to Example 1, Part A, 292 mg, 2.00 mmol) in CH 2 CI 2 (7 mL) was added a 5% solution of sodium hypochlorite ("Clorox", 4.2 mL, 2.8 mmol). The resulting mixture was stirred rapidly overnight (15 h) , the layers separated and the aqueous washed with CH 2 CI 2 . The combined organic was dried (MgS04) and concentrated in vacuo. The crude product was then purified using flash chromatography (EtOAc), affording 386 mg (58%) of the desired isoxazoline; mp: 102.0-102.9 °C. Part C: Ethvl 5 IR. S)-3-'3-(4-Ami inophenyl)isoxazolin-5- ylacetyllaminopropanoate Into a solution of ethyl 5 (R, S)-3-[3-(4-cyanophen- yl)isoxazolin-5-ylacetyl]aminopropanoate (1.65 mg, 5.00 mmol) in 10% DCM/EtOH (165 mL) was bubbled HCI gas for 2 hours. After 18 hours, the solvent was evaporated in vacuo, the residue dissolved in EtOH (100 mL) and ammonium carbonate (14.41 g, 150 mmol) added. The resulting suspension was stirred at room temperature for 18 hours, then filtered and the resulting filtrate concentrated in vacuo. The residue was then crystallized from EtOH/ether, giving 713 mg (41%) of the desired amidine; λ U NMR (300 MHz, CD 3 OD) 57.88 (AB quartet, Δ = 16.8 Hz, J = 8.4 Hz, 4H) , 5.13 (m, IH) , 4.12 (q, J = 7.3 Hz, 2H) , 3.58 (dd, J = 17.2, 10.6 Hz, IH), 3.44 (m, 2H) , 3.26 (dd, J = 17.2, 7.3 Hz, IH, coincident with solvent), 2.57 (m, 4H) , 1.25 (t, J = 7.3 Hz, 2H) . Part H: 5(i?.g)-3-r3-(4-Amidinophenyl)isoxazolin-5- vlacetvl1aminopropanoic Acid To a solution of ethyl 5 (R, S) -3 - [3 - (4-amidinophen- yl)isoxazolin-5-ylacetyl]aminopropanoate (346 mg, 1.00 mmol) in EtOH (6 mL) was added 0.5 M LiOH. Upon mixing, a precipitate of the zwitterionic product began to form. After stirring for 18 hours at room temperature, the solid was collected by filtration, affording 365 mg of the title compound; *H NMR (300 MHz, CD 3 OD) 57.86 (AB quartet, Δ = 18.3 Hz, J = 8.4 Hz, 4H) , 5.21 (m, IH) , 3.57 (dd, J = 17.2, 10.6 Hz, IH) , 3.43 (m, 2H) , 3.25 (dd, J = 17.2, 7.3 Hz, IH, coincident with solvent), 2.64 (dd, J = 14.6, 6.8 Hz, IH) , 2.52 (m, 3H) . Exam e 7ga Methvl N^-n-butvloxvcarbonvl-N - \3 - (4- amidinophenvl)isoxazolin-5(R)-vlacetvll-(S)-2.3- diaminopropionate Mesvlate salt. Methyl N 2 -n-butyloxycarbonyl-N 3 -[3-(4- amidinophenyl)isoxazolin-5(R) -ylacetyl]-(S)-2,3- diaminopropionate (500 mg, 1.03 mmol) was dissolved in 20 mL methanol and methanesulfonic acid (0.335 mL, 5 mmol) was added. The solution was allowed to stand at room temperature overnight and the solvent was removed by concentration. The residue was taken up in 20 mL methanol and the solution was allowed to stand at room temperature overnight. The solvent was removed by concentration and the residue was triturated with 8 mL 2-propanol. The solid product was isolated by filtration and dissolved in 12 mL 2-propanol by warming. After cooling to room temperature, crystalline solid formed. The mixture was allowed to stand in a refrigerator overnight. The crystal was filtered, washed with cold 2-propanol and dried. Yield 230 mg (41%). ES-MS (M+l) : calcd 448.3; found 448.3. Analysis for C 22 H33N5O 9 S: calcd C 48.61, H 6.13, N 12.88; found C 48.38, H 5.91, N12.65. Example 278b N^-n-butvloxvcarbonvl-N -"3- ( -amidinophenyl)isoxazolin- 5(R)-vlacetvll-(S)-2. -diaminopropionic acid TFA salt. To a solution of methyl N 2 -n-butyloxycarbony1-N 3 -[3- (4-amidinophenyl)isoxazolin-5 (R)-ylacetyl] -(S)-2,3- diaminopropionate hydrochloride salt (600 mg, 1.24 mmol) in 20 mL MeOH and 20 mL water cooled in an ice bath was added 1 N LiOH (1.3 mL, 1.3 mmol) over 5 min and the solution was stirred at room temperature for 5 hours. The solvents were removed by concentration at 25 °C. The residue was taken up in 3 mL water, 3 mL acetonitrile,and 0.2 mL TFA. Purification by reversed phase HPLC gave 610 mg (89%) product. ES-MS (M+l) : calcd 434.3; found 434.3. Example 298 i -Ω-Butanesulfonvl-Λ&- " 3- (4-amidino-phenyl) isoxazolin- 5 (R. S) -vlacetvll - ( S) -2 .3-diaminopropionic Acid TFA Salt Prepared according to Example 490a. MS (ESI, e/z, relative intensity): 454 (M + H) + , (100%) . Example 299 J\ -Phenvlsulfonvl-i -r3-(4-amidinophenyl)isoxazolin- 5 (R. S)-vlacetvll - (S)-2.3-diaminopropionic Acid TFA Salt Prepared according to Example 490a. MS (ESI, e/z, relative intensity): 474 (M + H) + , (100%). Example 317 i\£- (2-Phenvlethvlsulfonvl) -n&- '3- ( -amidino¬ phenyl) isoxazolin-5 (R. S) -vlacetvll - (5) -2.3- diaminopropionic Acid TFA Salt Prepared according to Example 490a. MS (ESI, e/z, relative intensity): 502 (M + H) + , (100%). Example 445a K&- (ft-Stvrvlsulfonvl) -M 3 -- " 3- (4-amidino-phenvl) isoxazolin- 5 (R. S) -vlacetvll - ( S) -2. -diaminopropionic Acid TFA Salt Prepared according to Example 490a. MS (ESI, e/z, relative intensity) : 500 (M + H)+, (100%). Example 478a N^-2.4.6-trimethylphenylsulfony1-N - " 3- (4-amidinophenyl) - isoxazolin-5- (R.S) -vlacetvll - (S) -2.3-diaminopropionic acid TFA salt. !H NMR (DMSO-d6) δ: 9.37 (s, 2H) , 9.06 (s,2H), 8.10 (q,J=6.22 Hz, IH) , 7.98( d,J=9.52 Hz, IH) , 7.87 (s,4H),6.98 (d, J=4.40 Hz, 2H) , 4.99(m,lH), 3.85 (m, IH) , 3.59-3.0 (m, 4H) , 2.55 (s, 6H) , 2.41 ( m,2H), 2.23 (s, 3H) ppm; Mass Spectrum (ESI) m/z (M+H) + 516.3 (100)%, High Res Mass Spectrum (M+H)+ calculated 516.190344, found 516.189999.sd088 Example 479a N2-2-chlorophenvlsulfonvl-N 3 — ' 3-(4-amidinophenyl)- isoxazolin-5-(R.S)-vlacetvll- (S)-2.3-diaminopropionic acid M.P. 138-140°C 3-H NMR (DMSO-d6) δ: 9.39 (s, 2H) , 9.27 (s, 2H) 8.30 (dd, J=4.40, 9.15 Hz IH) , 8.22 (m,lH), 7.96 (d, J=6.95 Hz, IH) , 7.88 (s, 4H) , 7.65 ( m,2H), 7.59 (m IH) , 5.04 (m, IH) , 4.03 (m IH) , 3.58 ( m IH) , 3.38 (m, IH) , 3.24 (m, 2H) , 2.59 (dd,j=6.22, 14.28 Hz, IH) , 2.43 (m,lH)ppm.Mass Spectrum (ESI) m/z (M+H)+ 508.1 (100%) , High Res Mass Spectrum (M+H) + calculated 508.107096, found 508.106929. sd089 Example 485a Nffl-2.3.5.6-tetramethylphenylsulfonyl-N 3 --T3-(4- amidinophenvl)-isoxazolin-5-(R.S)-vlacetvll -(S)-2.3- d minQ rp joni acid TFA salt, M.P.148-150 °C, ^-H NMR (DMSO-d6) δ: 9.38 (s, 2H) , 9.29 (s,2H), 8.09 (m, IH) , 7.97 (dd,J=4.40,9.15 Hz, IH) , 7.85 (s, 4H), 7.15 ( d, J=7.32Hz, IH) , 4.98 (m, IH) , 3.88 (q,J=6.96, 15.75 Hz,lH), 3.56 (m, IH) , 3.34-3.08 (m, 4H) , 2.43 (s,6H), 2.39 (m, IH) , 2.19 (s,3H), 2.18 (s, 3H), ppm. Mass Spectrum (ESI) m/z (M+H)+ 530.2 (100%); High Res Mass Spectrum (M+H) + calculated 530.208668; found 530.208357. sd090 Example 490a 5 (fl..?)-vlacetvll -(■?)-2.3-diaminopropionic Acid TFA Salt Part A: Methyl isβ-n-Prooanesulfonyl-.N 3 —Boc- ( S)-2.3- diaminopropionate To a solution of methyl i^-Boc- (S)-2,3- diaminopropionate (prepared in Ex 20, Part C, 410 mg, 1.88 mmol) in CH 2 CI 2 (5 mL) at 0 * C was added propanesulfonyl chloride (0.21 mL, 1.9 mmol) and Et 3 N (0.35 mL, 2.5 mmol) and the resulting mixture allowed to warm to room temperature overnight (18 h) . The mixture was washed with 0.1 M HCI, sat. NaHCθ 3 and brine, dried (MgSθ 4 ), and concentrated to give 530 mg (87%) of the desired sulfonamide as a viscous oil; CIMS (e/z, relative intensity): 342 (M + H)+, 100%. Part B: Methvl JjZ-n-Propanesulfonvl- ( S) -2.3-diamino- propionate Hydrochloride Salt To neat methyl 27 2 -.n-propanesulfonyl-.W 3 -Boc- (S)-2,3- diaminopropionate (520 mg, 1.60 mmol) was added 4 M HCl/dioxane (5 mL, 20 mmol) . The resulting solution was stirred at room temperature for 4 h, then it was concentrated in vacuo, giving an oil. Trituration with ether (3 x 10 mL) followed by drying under vacuum afforded 383 mg (92%) of the desired amine; CIMS (e/z, relative intensity): 225 (M + H) + , 100%. Part C: butoxycarbonylamidino)phenyl)isoxazolin-5 (R. S) -ylacetyll- ( S)-2.3-diaminopropionate To a suspension of 3-(4-W-Boc- amidinophenyl)isoxazolin-5-ylacetic acid (prepared in Example 32, 252 mg, 0.725 mmol), methyl N 2 -n- propanesulfonyl- (S) -2,3-diaminopropionate hydrochloride (189 mg, 0.726 mmol) in DMF (5 mL) was added Et3N (0.30 mL, 2.2 mmol) and TBTU (233 mg, 0.726 mmol). The resulting mixture was stirred for 4 h at room temperature, then was diluted with EtOAc (30 mL) . It was washed with water (4 x 20 mL) , sat. NaHCθ 3 (30 mL) , sat. NaCl and dried (MgSθ 4 ) . Concentration in vacuo followed by placing the material under vacuum until constant weight was achieved afforded 292 mg (73%) of the desired amide; MS (ESI, e/z, relative intensity): 554 (M + H) + , 100%. Part D: Methyl J^-ri-Propanesulfonvl-i^- \3 -(4-amidino- henvl)isoxazolin-5 (R. S)-vlacetvll - ( S)-2.3- dia inopropionate TFA salt To a solution of methyl W 2 -n-propanesulfonyl-JV 3 [3-(4- (2V- -butoxycarbonylamidino)phenyl)isoxazolin-5 (R, S) - ylacetyl]- (S)-2,3-diaminopropionate (284 mg, 0.513 mmol) in CH 2 CI 2 (4 mL) was added TFA (2 mL, 26 mmol) . After 2 h at room temperature, the solution was concentrated in vacuo and the residue triturated with ether (3 x 5 mL) . The resulting white powder was then placed under vacuum until constant weight was achieved, giving 260 mg (89%) of the desired benzamidine; MS (ESI, e/z, relative intensity): 454 (M + H) + , 100%. Part E: i^-n-Propanesulfonvl-J^-~3- (4-amidino¬ phenyl)isoxazolin-5 (R . S)-vlacetvll - ( S)-2. - diaminopropionic Acid TFA Salt To a solution of methyl i7 2 -n-propanesulfonyl-.N 3 [3-(4- amidinophenyl)isoxazolin-5 (R, S)-ylacetyl]- (S)-2,3- diaminopropionate (100 mg, 0.176 mmol) in MeOH (1 mL) was added 0.5 M LiOH (0.5 mL, 0.25 mmol) and the reaction stirred at room temperature overnight (18 h) . The resulting mixture was concentrated in vacuo, redissolved in water and the pH adjusted to 4 using 1 M HCl. Purification on reversed phase HPLC gave 10 mg (10%) of the desired carboxylic acid; MS (ESI, e/z, relative intensity): 440 (M + H) + , (100%). Example 492a N^-p-isopropvlphenvlsulfonvl-N -T3- (4- amidinophenvl) isoxazolin-5- (R.S) -vlacetvll - (S) -2.3- diaminopropionic acid TFA salt, 1 B1MR (DMSO) δ: 9.37(1H, s) , 9.09(1H, s) , 8.15(2H, m) , 8.78(4H, d, J=1.465Hz), 7.09(2H, d, J=8.423Hz), 7.44(2H, m) , 4.98(lH,m), 3.93(1H, m) , 3.59(2H, m) , 3.50(2H, m) , 3.22(2H, m) , 2.98(1H, m),2.45(2H, m) , 1.22(6H, m)ppm; ESI mass spectrum 516.3 (M+H, 100) + free base. Example 512 Methvl N2-(jn-toluenesulfonvl)-Nl-r3-(4-amidino-2- fluorophenyl) isoxazolin-5-vlacetvll -ff-2.3- diaminopropionate hydrochloric acid salt Part A: 3-Fluoro-4-methvlbenzamide 3-Fluoro-4-methylbenzoic acid (10 g, 65 mmol) was boiled in thionyl chloride (100 mL) under a drying tube for 2.5 h. The excess SOCI 2 was removed by distillation. The oily acid chloride product was diluted with CH 2 CI2 (100 mL) and cooled in an ice bath. Cone. aq. NH 3 (20 mL) was added dropwise, and stirring continued at 0 °C for 0.5 h. The CH 2 CI 2 was removed in vacuo, then the residue was diluted with EtOAc. The mixture was extracted with sat. aq. Na 2 Cθ 3 (2x) , H 2 O, and brine, dried (MgSθ 4 ) , and concentrated to yield 9.9 g of a pale yellow solid; mp 161-163 °C; IR(KBr) 3382, 1654 cm "1 ; Anal. Calc. for C 8 H 8 FNO: C, 62.74; H, 5.27; N, 9.15; F, 12.40. Found: C, 62.66; H, 5.17; N, 9.12; F, 12.28. Part B: 3-Fluoro-4-methylbenzonitrile A solution of trichloroacetyl chloride (7.3 mL, 65 mmol) in CH2CI2 (20 mL) was added dropwise over 0.5 h to a solution/suspension of the Part A amide (9.0 g, 59 mmol) and Et 3 N (17 mL, 120 mmol) in CH 2 CI 2 (80 mL) at 0 °C. After 40 min, the mixture was concentrated in vacuo, then diluted with Et 2 θ. This solution was extracted with 1 HCI, sat. aq. NaHC0 3 , H 2 O, and brine, then dried (MgS0 4 > , and concentrated to yield 7.8 g of a tan solid; mp 45-47 oC; iR(KBr) 2232 cm -1 ; HRMS, e/z Calc. for (M+H)+: 135.0484. Found: 135.0482. Part C: 2-Fluoro-4-cvanobenzvlbromide N-Bromosuccinimide (9.6 g, 54 mmol) and the part B substrate (7.3 g, 54 mmol) were heated under reflux in CCI 4 (100 mL) under N 2 with irradiation with a high intensity visible lamp for 2 h. After cooling to ambient temp., the mixture was filtered through a Celite pad and concentrated in vacuo. The crude product was — recrystallized from hot cyclohexane (4x) to yield 4.5 g of off-white needles; mp 75-77 °C; IR(KBr) 2236 cm -1 ; HRMS, e/z Calc. for (M+H)+: 213.9668. Found: 213.9660. Part D: 2-Fluoro-4-cvanobenzaldehyde The part C benzyl bromide (3.68 g, 17 mmol), trimethylamine N-oxide dihydrate (7.6 g, 68 mmol), CH2CI2 (15 mL) , and DMSO (30 mL) were stirred at 0 °C for a few h, slowly warming to ambient T overnight. The mixture was diluted with water (30 mL) and brine (30 mL) , and extracted with Et 2 θ (4x) . The combined organics were washed with brine, dried (MgSθ4) , and concentrated to yield 1.1 g of a yellow solid; IR(KBr) 2238, 1706 cm -1 ; HRMS, e/z Calc. for (M+H)+: 150.0355. Found: 150.0341. Part E: 2-Fluoro-4-cvanobenzaldoxime The part D aldehyde (1.1 g, 7.4 mmol), hydroxylamine hydrochloride (1.0 g, 15 mmol), K 2 CO 3 (1.0 g, 7.4 mmol), water (1 mL) , and MeOH (10 mL) were heated under reflux for 2.25 h. After brief cooling, the mixture was diluted with water, and the insoluble product was collected by filtration, then rinsed with more water. Drying under high vacuum provided 0.94 g of a pale yellow amorphous solid; mp 179-182 °C; IR(KBr) 3256, 2236, 1556 cm -1 ; HRMS, e/z Calc. for (M+H)+: 165.0464. Found: 165.0455. Part F: Methvl 3- (4-cvano-2-fluorophenyl) isoxazolin-5- vlacetate The part E oxime was allowed to react with Clorox and methyl vinylacetate n the usual way to afford the isoxazoline as a yellow solid in 32% yield; mp 92-94 °C; IR(KBr) 2240, 1746 cm -1 ; HRMS, e/z Calc. for (M+H)+: 263.0832. Found: 263.0818. Anal. Calc. for C 13 H 11 FN 2 O 3 : C, 59.54; H, 4.23; N, 10.68; F, 7.24. Found: C, 59.84; H, 4.31; N, 10.53; F, 7.26. Part G: Methvl 2- (in-toluenesulfonyl) -N 3 -- '3- (4-fcert- butvloxvcarbonvlamidino-2-fluorophenyl)isoxazolin- (R. S) -5- vlacetvl- ( S) -2.3-diaminopropionate. The part F intermediate was converted to the title compound by the usual sequence of steps: Pinner amidine synthesis, amidine BOC protection, ester saponification, and condensation with the 2,3-diaminopropionate sulfonamide ester; MS (DCI, NH 3 ) 620 (M+H), 520. Part H: Methvl N 2 -- (jn-toluenesulfonvl) -N 3 -- \3 - (4-amidino-2- fluorophenvl) isoxazolin- (R. S) -5-vlacetvl- (S) -2.3- diaminopropionate hydrochloric acid salt. The BOC group was removed from the part G intermediate by treatment with 4M HCI in dioxane to provide a yellow gum; HRMS, e/z Calc. for (M+H) + : 520.1666. Found: 520.1675. Example 512A N2- (m-Toluenesulfonvl) -N 3 -- \ 3 - (4-amidino-2- fluorophenvl) isoxazolin- (R) -5-vlacetvl- ( S) -2 .3- diaminopropionate hydrochloric acid salt Part A: N^-(m-Toluenesulfonvl)-N 3 -- ' 3-(4-fcert- butvloxvcarbonvlamidino-2-fluorophenyl)isoxazolin- (R. S)-5- γlacetγl-(.?)-2,3-diaminopropionate, The intermediate from Example 512, Part G (0.60 g, 0.97 mmol) was saponified using lithium hydroxide hydrate (61 mg, 1.45 mmol) in water (1 mL) and methanol (1 mL) at room temperature for 3 d. The mixture was extracted with ethyl acetate, the aqueous layer was acidified with pH 4 buffer, and it was extracted with ethyl acetate. The extracts were dried and concentrated to 0.427 g of a clear glass. This material was flashed chromatographed using a methanol/chloroform gradient solvent system, starting with chloroform and progressing through 2%, 10%, 15%, and 20% methanol/chloroform to give 0.360 g (57 %) of a clear glass. *H NMR (DMSO-d6/ 300 MHz) δ 9.09 (br, IH) , 7.88- 7.80 (m, 3H) , 7.60-7.56 (m, 2H) , 7.47-7.42 (m, 2H) , 5.00- 4.97 (m, IH), 3.62-3.57 (m, IH) , 3.29-3.16 (m, 4H) , 2.58- 2.43 (m, 2H) , 2.37 (s, 3H) , 1.45 (s, 9H) . HRMS (FAB, glycerol) Calc. for (M+H) + : 606.2034. Found: 606.2043. Part B: Ni-(m-Toluenesulfonvl)-N 3 --T3-(4-amidino-2- fluorophenvl)isoxazolin- (R)-5-vlacetvl- ( s)-2.3- diaminopropionate hydrochloric acid salt. The intermediate from Part A (0.344 g, 0.57 mmol) was dissolved in 4M HCI in dioxane and stirred at room temperature for 21.5 h. The solution was diluted with ether and the precipitated white solid was collected and dried, yielding 0.367 g. This material was subjected to super critical fluid chiral Prep HPLC on a Chiral OG 2 in x 25 cm column using 0.1% TFA, 25% methanol, 75% carbon dioxide as eluent at a flow rate of 20 mL/min to separate the isoxazoline isomers. The second eluting, (R, S) , isomer was obtained as a white solid. 1 H NMR (DMSO-σ? 6 , 300 MHz) δ 12.81 (br, IH) , 9.53 (s, 1.5H), 9.29 (s, 1.5H), 8.17 (m, 2H) , 7.95 (t, J=7.7 Hz, IH) , 7.86 (d, J=12.0 Hz, IH), 7.40 (d, J=9.5 Hz, IH) , 7.60-7.56 (m, 2H) , 7.46-7.41 (m, 2H) , 4.97-4.93 (m, IH) , 3.88-3.86 (m, IH) , 3.59-3.55 ( , IH) , 3.42-3.14 (m, 3H) , 2.52-2.45 (m, IH) , 2.41-2.33 (m, 4H) . HRMS (FAB, glycerol) Calc. for (M+H) + : 506.1510. Found: 506.1494. Example 51 Methvl N2- (n-butvloxvcarbonvl) -Ni- T3- (3-amidinopvrid-6- vl) isoxazolin-5-vlacetvll -5-2.3-diaminopropionate hydrochloric a id salt Prepared using methods described in Ex. 514 to provide a pale yellow powder; mp 90-110 °C (dec) ; HRMS, e/z Calc. for (M+H) + : 449.2149. Found: 449.2140. Example 514 Methvl 2- (m-toluenesulfonvl) -N - T3- (3-amidinopvrid-6- vl)isoxazolin-5-vlacetvll-S'-2. -diaminopropionate hydrochloric acid salt Part A: 3-cvano-6-pvridaldoxime 5-Cyano-2-picoline (25 g, 0.21 mol) and I 2 were heated under reflux in DMSO (200 mL) for 1 h. After cooling to RT, hydroxylamine hydrochloride (16 g, 0.23 mol), K2CO 3 (29 g, 0.21 mol), and water (21 mL) were added. The resulting mixture was heated to 80 °C for 2.5 h, cooled, diluted with water (100 mL) and much acetone, and absorbed onto silica gel by concentration. Chromatography on silica gel, eluting with 0% to 50% EtOAc in hexane, afforded 12.2 g of a tan solid; mp 204-207 °C (dec); HRMS, e/z Calc. for (M+H) + : 148.0511. Found: 148.0516. Part B: Methyl 3- (3-cyanopyrid-6-yl)isoxazolin-5- vlacetate The oxime of Ex. 514, part A was converted to the isoxazoline as described in Ex. 516, part B in 76% yield as a yellow solid; mp 97-98 °C; HRMS, e/z Calc. for (M+H)+: 246.0879. Found: 246.0881. Anal. Calc. for C 12 H 11 N 3 O 3 : C, 58.77; H, 4.52; N, 17.13. Found: C, 58.74; H, 4.51; N, 17.11. Part C: Methvl 3-(3-fc-butvloxvcarbonvlamidinopvrid-6- vl)isoxazolin-5-vlacetate The nitrile of Ex. 514, part B was converted to the amidine as described in the method of Ex. 516, parts D & E (except that 0.6 eq. NaOMe was required), and BOC protected in standard fashion to afford, after purification, a yellow solid; mp 143 °C (gas evolves); HRMS, e/z Calc. for (M+H)+: 363.1668. Found: 363.1675. Anal. Calc. for C 17 H 22 N 4 O 5 : C, 56.35; H, 6.12; N, 15.46. Found: C, 56.35; H, 6.10; N, 15.39. Part D: Lithium 3-(3- -bπtvloxvcarbonvlamidinopvrid-6- vl)isoxazolin-5-vlacetate The ester of Ex. 514, part C was saponified and lyophilized as described in the method of Ex. 516, part F to give a colorless amorphous solid quantitatively; mp >230 °C; HRMS, e/z Calc. for conjugate acid (M+H) + : 349.1512. Found: 349.1527. Part E: Methvl N -(m-toluenesulfonvl)-N≥- \3 - ( 3 - tert- butvloxvcarbonvlamidinopvrid-6-vl)isoxazolin- (R. s)-5- vlacetyl1-( s)- ,3-diaminopropionate, The Part D lithium carboxylate was condensed with methyl N 2 -(m-toluenesulfonyl)- (S)-2,3-diaminopropionate hydrochloride using conditions described above to give a yellow foam. HRMS, e/z Calc for (M+H)+: 603.2237. Found: 603.2223. Part F: Methvl 2- (m-toluenesulfonvl)-N-- \3 -(3- amidinopvrid-6-vl)isoxazolin- (R . S) -5-vlacetvll - ( s)-2.3- diaminopropionate hydrochloric acid salt. The protected amidine of Part E was treated with 4M HCI in dioxane to provide a yellow solid; mp 90°C (dec) ; HRMS, e/z Calc. for (M+H) + : 503.1713. Found: 503.1718. Example 514A N2-(m-Toluenesulfonvl)-Nl- \ 3 -(3-amidinopvrid-6- vl)isoxazolin- (R)-5-vlacetvll - (S) -2 . -diaminopropionic acid trifluoroacetic acid salt Part A: Lithium 2-(m-toluenesulfonvl)-N - \3 - (3 - tert- butvloxvcarbonvlamidinopvrid-6-vl)isoxazolin- (R . S)-5- ylacetyll-(g)-2, -diaminopropionate. The methyl ester of Example 514, Part E (0.16 g, 0.27 mmol) was saponified by stirring with 0.5 M LiOH (0.54 mL, 0.27 mmol) in methanol (2 mL) at room temperature. The mixture was concentrated in vacuo to give 0.16 g (99 %) of a tan solid; HRMS, e/z Calc for (M+H) + : 589.2081. Found: 589.2086. Part B: ^-(m-Toluenesulfonvl)-N-t-T3-(3-amidinopvrid-6- vl)isoxazolin- (R)-5-vlacetvll- ( S) -2.3-diaminopropionic acid trifluoroacetic acid salt. The lithium salt of Part A was treated with 4M HCI in dioxane to give a tan foam. This material was purified by Prep reverse phase HPLC on a Vydac C18 2 x 25 cm column using a gradient solvent system starting with 0.05% TFA in water progressing to 80:20 0.05% TFA in water: 0.05% TFA in acetonitrile over 50 m, the purified material was subjected to super critical fluid Prep chiral HPLC on a Chiral OG 2 in x 25 cm column using 0.1% TFA, 25% methanol, 75% carbon dioxide as elutant at a flow rate of 20 mL/min to separate the isoxazoline isomers. The second eluting, (R, S) , isomer was resubmitted to reverse phase Prep HPLC as above to give the title compound as a tan solid. X H NMR (DMSO-dβ, 300 MHz) δ 2.31 (dd, J=15.0, 7.0 Hz, IH, partially obscured), 2.37 (s, 3H) , 2.48-2.59 (m, IH, under DMSO) , 3.02-3.15 (m, IH) , 3.22 (dd, J=17.6, 10.6 Hz, IH) , 3.32-3.42 (m, IH, under water peak) , 3.55 (dd, J=17.6, 10.6 Hz, IH), 3.82-3.92 (m, IH) , 4.98-5.11 (m, IH), 7.39-7.49 (m, 2H) , 7.54-7.61 (m, 2H) , 8.08-8.15 (m, 3H) , 8.25 (dd, J=8.4, 2.2 Hz, IH) , 9.01 (d, J=1.8 Hz, IH) , 9.24 (br s, 2H) , 9.53 (br s, 2H) , 12.78 (very br s, IH) . MS (ESI) 489 (M+H, 65), 288 (100), 245 (27). Example 515 Methvl N2- (n-butvloxvcarbonvl)-N -T3-(2-amidinopvrid-5- vl)isoxazolin-5-vlacetvl1 -S-2 .3-diaminopropionate hydrochloric acid salt In similar fashion to the method described in Ex. 516, the compound of Ex. 514, part E was coupled with methyl N 2 -(n-butyloxycarbonyl)-2,3-diaminopropionate hydrochloride using conditions described above, followed by BOC deprotection with 4 M HCl/dioxane to yield a pale yellow powder; HRMS, e/z Calc. for (M+H)+: 449.2149. Found: 449.2154. Example 516 Methvl 2-(m-toluenesulfonvl)-N 3 -- \3 -(2-amidinopvrid-5- vl)isoxazolin-5-vlacetvll -S-2 . -diaminopropionate hydrochloric acid salt Part A: 2-Chloro-5-pyridaldoxime 2-Chloro-5-formylpyridine (2.1 g, 15 mmol) was condensed with hydroxylamine hydrochloride in the usual way to give the oxime, 1.5 g, as a yellow crystalline solid; mp 171-175 °C (dec); HRMS, e/z Calc. for (M+H)+: 157.0169. Found: 157.0175. Part B: Methyl 3-(2-chloropyrid-5-yl)isoxazolin-5- vlacetate Sodium hypochlorite (5% wt, 20 mL) was added dropwise over 1.75 h to a mixture of the part A oxime (1.13 g, 7.2 mmol), methyl vinylacetate (70% purity, 3.0 g, 21 mmol), CH 2 CI 2 (40 mL) , and DMF (4 mL) with stirring at ambient temperature. The CH 2 CI 2 was evaporated, and the mixture was diluted with EtOAc, extracted with water (5x) and brine, then dried (MgSθ 4 ), filtered, and concentrated. Chromatography on silica gel, eluting with 0% to 70% EtOAc in hexane, afforded 1.4 g of a solid; mp 94-96 °C; HRMS, e/z Calc. for (M+H)+: 255.0536. Found: 255.0531. Part C: Methvl 3-(2-cvanopvrid-5-vl)isoxazolin-5- vlacetate The part B chloropyridine (0.51 g, 2.0 mmol), zinc cyanide (0.23 g, 2.0 mmol), Pd(PPh 3 ) (0.12 g, 0.10 mmol), and DMF (2 mL) were heated to 80 °C under N 2 for 3 days. After cooling and concentration, the mixture was preabsorbed onto silica gel by concentration from CHCI 3 . Chromatography on silica gel, eluting with 0% to 90% EtOAc in hexane afforded 0.28 g of a pale yellow solid; mp 115- 116 °C; HRMS, e/z Calc. for (M+H) + : 246.0879. Found: 246.0880. Anal. Calc. for C 12 H 11 N 3 O 3 : C, 58.77; H, 4.52; N, 17.13. Found: C, 58.68; H, 4.48; N, 16.90. Part D: Methvl 3-(2-amidinopvrid-5-vl)isoxazolin-5- vlacetate formic acid salt The part C cyanopyridine (0.47 g, 1.9 mmol) and sodium methoxide (prepared in situ from Na metal, 4 mg, 0.2 mmol were stirred in dry MeOH (6 mL) at ambient temperature for 16 h, after which ^ NMR analysis of a reaction aliquot indicated complete formation of methyl imidate [note 9.25 (s, IH) and 3.92 (s, 3H) ] . Ammonium formate (0.60 g, 9.5 mmol) was added to the reaction mixture, and stirring continued for 7 h. The mixture was absorbed onto silica gel by concentration in vacuo. Chromatography on silica gel, eluting with 0% to 20% MeOH in CHCI 3 , and concentration afforded 0.61 g of the amidine as an off-white solid; mp 180-182 °C (dec); HRMS, e/z Calc. for (M+H)+: 263.1144. Found: 263.1148. Part E: Methvl 3- (2-t-butvloxvcarbonvlam. inonvrid-5- vl)isoxazolin-5-vlacetate The part D amidine was BOC protected in standard fashion to afford, after silica gel chromatographic purification, a 41% yield of a colorless foam; HRMS, e/z Calc. for (M+H) + : 363.1668. Found: 363.1682. Part F: Lithium 3-(2-t-butvloxvcarbonvlamidinopvrid-5- yl)isQxazQlin-5-ylacetate The part E methyl ester (0.37 g, 1.0 mmol) was saponified by stirring with 0.5 M. LiOH in MeOH at RT. The MeOH was removed in vacuo, then the aqueous mixture was frozen and lyophilized to produce a pale yellow solid quantitatively; HRMS, e/z Calc. for conjugate acid (M+H) + : 349.1512. Found: 349.1531. Part G: Methyl N 2 --(m-toluenesulfonyl)-N 3 --T3-(2- amidinopvrid-5-vl)isoxazolin-5-vlacetvl1-g-2:3- diaminopropionate hydrochloric acid salt The part F lithium carboxylate was condensed with methyl N 2 -(jn-toluenesulfonyl)-2,3-diaminopropionate hydrochloride using conditions described above, followed by standard BOC deprotection with 4 M HCl/dioxane to yield a yellow amorphous solid; HRMS, e/z Calc. for (M+H) + : 503.1713. Found: 503.1707. Example 516A N 2 --(m-Toluenesulfonvl)-N - 3 -(2-amidinopvrid-5- vl)isoxazolin- (R. S) -5-vlacetvll - (S) -2 .3-diaminopropionic acid trifluoroacetic acid salt. The methyl ester of Example 516, Part G (31.4 mg, 54.6 nmol) was dissolved in 6M aqueous hydrochloric acid (1 mL) and the mixture was stirred at room temperature for 44 h. The yellow solution was concentrated and subjected to Prep reverse phase HPLC as described in Example 514A, Part B to give 25.0 mg (75 %) of a white solid, mp 158.5-161.5°C. ^-H NMR (DMSO-d δ , 300 MHz) δ 2.31-2.44 (m, IH) , 2.37, 2.38 (singlets, 3H) , 2.50-2.60 (m, IH, under DMSO), 3.00-3.10 (m, 0.5H), 3.12-3.36 (m, 2H) , 3.38-3.48 (m, 0.5H), 3.60 (ddd, J=17.2, 10.6, 5.9 Hz, IH) , 3.85-3.95 (m, IH) , 4.95-5.11 (m, IH) , 7.39-7.45 (m, 2H) , 7.52-7.60 (m, 2H) , 8.10-8.22 (m, 2H) , 8.28-8.40 (m, 2H) , 9.06 (s, IH) , 9.37 (br s, 2H) , 9.60 (br s, 2H) . MS (ESI) 489 (M+H, free base, 100), 214 (17). Example 528a Nl-o-Bromophenvlcarbonvl-N - L- (4- amidinophenvl)isoxazolin-5- (R.S) -vlacetvll -(S) -2.3- diaminopropionic acid. The title compound was obtained as its TFA salt from readily accessible N2-amino-3- [ (4- tertbutyloxycarbonylamidino)phenylisoxazolin-5- (R,S) - ylacetyl] - (S) -2,3-diamino-tertbutylpropionate by common acylation techniques with 2-bromobenzoyl chloride. Removal of the tert-butyl protecting groups with TFA afforded the desired product as colorless crystals. M.P. 172-174°C; !H NMR (DMSO d6) δ: 7.80(d, J=8Hz,2H), 7.51- 7.63(m,3H), 7.28(m,2H), 7.12 (dd,IH) , 6.61(m,lH), 5.05(m,lH), 4.81(q, IH) , 3.80(d, 3H) , 3.06(m,lH), 2.53 (m,2H), 1.53 (s, 9H)ppm; ESI mass spectrum 516 (M+H, 100 free base); HRMS calcd. for C22H23Br 5θ5 516.088255, found 516.086811(free base) .se729 Example 5 A? 2 -- (2.5-Dimethyl- -chlorobenzenesulfonvl) -A - \ 3 - (4- amidinophenvl) isoxazolin-5 (R . S) -vlacetvll - ( S) -2.3- diaminopropionic Acid TFA Salt Prepared according to Example 490a. MS (ESI, e/z, relative intensity): 536 (M + H) + , (100%). Example 540 N2-methvlphenvlcarbonvl-N2- \3 - ( -amidinophenyl)isoxazolin- 5-(R.S)-vlacetvl1-(S)-2.3-diaminopropionic acid. Obtained as colorless crystals, M.P. 166-168°C; 1 H NMR (DMSO d6) δ: 9.38(b, 2H) , 9.18(b,2H), 8.42(t,lH), 8.20(m,lH), 7.21(d, J=10.2Hz, 4H) , 5.00(m, IH) , 4.50(m,lH), 3.30-3.73(m.3H) , 2.58-2.65(dd,IH) , 2.41-2.50(dd, IH) , 2.34(s,3H)ppm; ESI mass spectrum 452 (M+H, 100 free base); HRMS calcd for C23H26N5O5 452.193394, found 452.1922251(free base) .se728 Example 540a Nl-methvlphenvlsulfonvl-N 3 —f3- (4-amidinophenyl)isoxazolin- 5-(R.S)-vlacetvl1-(S)-2. -diaminopropionic acid. Obtained as colorless crystals M.P. 136-138°C; ^ NMR (DMSO d6) δ: 9.39(b, 2H) , 9.27(s,2H), 8.18(m,2H), 7.80(d, J=7.7Hz,lH), 7.44(t,lH), 7.32(q,2H), 4.96(m,lH), 3.90(b, IH) , 3.81(q, IH) , 3.40-3.60(m,2H) , 3.04(m,2H), 2.60(s,2H), 2.24(dd, J=7.7 and 15.6Hz)ppm; ESI mass spectrum 488(M+H, 100 -free base). HRMS calcd for. C22H25 5SO6 488.160381, found 488.16292 (free base). Example 606 Methvl Nl-p-toluvlsulfonvl-Nl-r.3- (4- σuanidinophenvl)isoxazolin-5-(R.S) -vlacetvll-(S)-2.3- diaminopropionic acid TFA Salt Part A: The methyl di-Boc-quanidino-α-toluyl ester was prepared according to the procedure for example 602. Deprotection of the Boc-protecting groups then afforded example 606 as the TFA salt. iHNMR (DMSO) δ: 8.30(dd, 2H) , 8.09(m, IH) , 7.68(d, J=8.2Hz, 2H) , 7.60(d, J=8.0Hz, 2H) , 7.35(d, J=8.2Hz, 2H) , 7.28(d, J=8.4Hz, 2H) , 4.88(m, IH), 4.00(m, IH) , 3.42(dt, IH) , 3.38((d, 3H) , 3.05- 3.33(m, 3H) , 2.40(m, IH) , 2.36(s, 3H) , 2.25(m,lH)ppm; HR MS calcd. for C23H29 6O6S 517.186930; Found 517.186911. sa710 Part B: Lithium hydroxide saponification on the product of part A then afforded example 605 in 39% yield after recrystallization from dichloromethane and ether. 1HNMR (CD3OD) δ: 8.29(brd, S, 2H) , 8.05(brd, s, IH) , 7.75(d, J=8.lHz, 2H) , 7.70(d, J=8.4Hz, 2H) , 7.31(d, 4H) , 5.02(m, IH) , 3.85(m, IH) , 3.60(m, 2H) , 3.41(m, IH) , 3.20(m, IH) , 2.64(dd, IH) , 2.43(dd, IH) , 2.40(s, 3H) ;HR MS calcd. for C22H27N6O6S 503.171280; Found 503.170531. sa760 Example 625 isoxazolin-5-(R.S)-vlacetvll-(S)-2.3-diaminopropionic acid TFA salt, Part A: l-β-nitroethene-4-benzonitrile (Bourgvignon, J.et al., Can, J. Chem., 1985, £1, 2354) (0.9 g, 5.17 mmol) was reduced according to the method of Nakamura, et al. (Chem. Lett.,1985, 523) to afford 0.73 g (80%) of desired product. ^-H NMR (CDCI3) δ: 7.73 (d, J=8.42 Hz, 2H) J .7.43 (d, J=8.42 Hz, 2H) , 4.75 (d, J=6.96 Hz, 2H) , 3.48 (d, J=6.96 Hz, 2H) ppm; Mass Spectrum (CH4-CI) m/z (M+H)+ 177 (100%) . Part B: l-β-nitroethane-4-benzonitrile (1.38 g, 7.8 mmol) was condensed with tert-butyl acrylate (1.4 ml, 9.4 mmol) according to the method of Curran, D.P., et al (J. Org. Chem., 1988, 51, 5369) to afford the crude ester. The ester was difficult to purify so the ester was hydrolyzed in 30 ml of 30% TFA/CH2CI2 for 48h. The crude acid was extracted into aqueous NaHC03 . The aqueous layer was acidified and extracted with CH2CI2 and dried (MgS04) to afford 1.48 g (80%) orange solid.3-H NMR (CDCI3) δ: 7.97 (brd, IH) , 7.64 (d, J=8.42 Hz, 2H) , 7.36 (d, J=8.42 Hz, 2H) , 5.07 (dd, J=6.59,10.98 Hz, IH) , 3.79 (s, 2H) , 3.20 (m, 2H) ppm. Part C: The product of Part B (366 mg, 1.6 mmol) was coupled with methyl-L-N -p-toluylsulfonyl-2,3- diaminoproprionate using procedure described in Example 43D. Chromatography on silica gel (2%MeOH/CH2Cl2) afforded 388 mg (50%) .mp 141-144°C; NMR (CDCI3) δ: 7.75-7.65 (m, 2H), 7.60 (d, 2H) , 7.45 (d, 2H) , 7.30 (dd, 2H) , 7.20 (m, IH) , 5.50 (dd, IH), 4.99 (m, IH) , 4.20-3.99 (m, IH) , 3.90- 3.70 (m, 3H) , 3.55 (s, 3H) , 3.30 (m, 3H) , 2.42 (s, 3H)ppm; Mass Spectrum (NH3-CI) m/z (M+H)+ 485.2 (100%); IR (KBr) 3276, 1738, 1666, 1538, 1338, 1162, 862, 822 cm" 1 . Part D: The product of Part C (360 mg, 0.74 mmol) was subjected to the Pinner reaction previously described. Chromatography on silica gel (5-15% MeOH/CH2Cl2) afforded 313 mg (75%) .mp 133-137°C; X H NMR (DMSO-d6) δ: 9.20 (brd, 2H) , 8.26 (t, J=5.86 Hz, IH) , 7.80 (d, J=8.06 Hz, 2H) , 7.63 (d, J=8.06 Hz, 2H) , 7.51 (d, J= 8.06 Hz, 2H) , 7.38 (d, J=8.06 Hz, 2H) , 4.87-4.73 (m, IH) , 3.98-3.89 (m, IH) , 3.80 (s, 2H), 3.34 (s, 3H) , 3.34-3.31 (m, 3H) , 3.28 (m, 2H) , 2.98 (dd, J=6.23, 17.21 Hz, IH) , 2.37 (s, 3H)ppm; Mass Spectrum (ESI) m/z (M+H)+ 502.2 (100%). Part E: To the product of Part D (182 mg, 0.338 mmol) was added 1 ml MeOH, followed by lithium hydroxide (31 mg, 0.74 mmol). The mix ture was stirred for 18h and the solvent was removed in vacuo and water added. HCI was added until a precipitate formed. The solid was filtered off and stirred in 2 ml HCI for 1 h. The acid was removed in vacuo to afford 72 mg of product which contained 15% methyl ester. Purification via standard HPLC techniques then afforded the desire product. 1 H NMR (DMSO -d6) δ: 9.35 (s, 2H), 9.08 (s, 2H) , 8.14-8.07 ( , 2H) , 7.78 (d, J=7.32 Hz, 2H) , 7.66 (dd, J= 2.19, 8.42 Hz, 2H) , 7.51 (d, J=7.69 Hz, 2H) , 7.36 (d, J=8.42 Hz, 2H) , 4.86-4.69 (m, IH) , 3.92- 3.80 (m, IH), 3.79 (s, 2H) , 3.30-2.90 (m, 4H) , 2.49 (s, 3H)ppm; Mass Spectrum (ESI) m/z ' (M+H)+ 488.3 (100%). Example 666 2-(methvl)-N^-m-toluvlsulfonvl-Nl-T3-(4-amidinophenvl)- isoxazoline-5-(R.S) -vlacetvll-(S)-2.3-diaminopropionic acid TFA salt. Part A: Methyl N 3 -[3- (4-cyanophenyl)isoxazolin-5- (R,S)-ylacetyl]-N^-m-toluyl-(S)-2,3-diaminopropionate obtained as the precursor to Example 300 was subjected to a selective Mitsonubo-N-methylation of the sulfonamide (Acta. chem. scand. 1994,48,324333) ,to afford methyl N 2 - (methyl)-N 2 -m-toluyl-N 3 -[3-(4-cyanophenyl)isoaxzolin-5- (R,S) -ylacetyl]-(S)-2,3-diaminopropionate as colorless crystals. M.P=148-149°C. 1 HNMR(CDCl3) δ: 7.77 (d, 2H) , 7.60(m, 2H) , 7.46 (m, 2H) , 7.41(d, 2H) , 6.07(t, IH) , 5.21(m, IH) , 4.80 (dd,J=4.8&10.6Hz, IH) , 3.81(m, IH) , 3.56(s, 3H) , 3.43 (m, 2H) , 3.25(dd,J=7.4&17.4Hz, IH) , 2.80(dd,J=8&17.lHz,lH) , 2.77(s, 3H) , 2.56(dd, J=7.7&15.lHz,lH) , 2.44(s, lH)ppm; IR (KBr) 3340, 2224, 1726, 1644, 1610, 1596, 1534, 1440, 1414, 1402, 1366, 1336, 1284, 1258, 1212, 1144, 1012, 934, 918, 896, 844, 812, 784, 690, cm -1 . ESI mass spectrum 499 (M+H,48), 359(63), 279(53), 198(100). HR MS calcd. for C24H27N4O6S 499.165132 found 499.164946. sd267 Part B: The cyano procursor from part A was then subjected to the Pinner amidine reaction conditions as per example 275E to obtain the desired compound as the methyl ester sc758in 60% overall yield. Saponification with 6N HCI followed by HPLC purification [solvent A: CH3CN: H2O: TFA / 2%: 98%:0.05%, solvent B: CH3CN:H2θ:TFA / 80%:20%:0.05%] afforded the desired amidine acid compound 666 as its TFAsalt. 1 HmR (CDCI3) δ: 9.35(s, IH) , 9.23(s,lH), 8.20(brd, 2H) , 7.89(brd, 4H) , 7.57 (d,J=8Hz, 2H) , 7.40(d,J=8Hz, 2H) , 5.05(m, IH) , 4.67 (m, IH) , 3.50- 3.66(m, 3H) , 3.20-3.40(m, 2H) , 2.80(s, 3H) , 2.55 ( , IH) , 2.35(m/s, 4H)ppm; ESI mass spectrum 502 (M+H, 100), HRMS calcd for C23H27N5SO6 502.176031 found 502.176612. Example 717 Afc-Phenvlmethv3sulfonvl-A£-r3-(4-amidino- henvl)isoxazolin-5 (R. S)-vlacetvll - ( S)-2.3- diaminopropionic Acid TFA Salt Prepared according to Example 490a. MS (ESI, e/z, relative intensity): 488 (M + H) + , (100%). Example 816 w2.-n-toluvlaulfonvl-N3.-r5-(4-amidinophenyl)isoxazolin-3- (R.S)-vl-acetvll-(S) -2.3-diaminopropionic acid TFA salt. The title compound was prepared in a manner similar to example 829. Saponification of the methyl ester via standard techniques then afforded crude compound 816, which was purified via HPLC [graduant flow, solvent A CH3CN(2%) : H2θ(98%) : TFA(0.05%), solvent B: CH3CN(80%) : H2O(20%) : TFA(0.05%),] to afford colorless crystals of compound 816 as its TFA salt. ^-HNMR(CDCI3) δ: 9.30(brds, 4H) , 8.34(t, IH) , 8.12(d,J=9.2Hz, IH) , 7.81(d, J=8.3Hz, IH) , 7.60(d, J=8.0Hz, IH) , 5.60(dt, IH) , 3.81(q, IH) , 3.43 (dt, IH), 3.25(m, IH) , 3.20(d, IH) , 3.03 (m, IH) , 2.89(m, IH) , 2.50(s, IH) , 2.34(s,3H)ppm; ESI mass spectrum 488(M+H,100) , HRMS calcd. for C22H26N5O6S 488.160381; found 488.158785. Example 952 Methvl Nl-m-toluenesulfono-Nl-T3-(4-N- isopropvlamidophenvl)isoxazolin-5R-vlacetvll-S-2.3- diaminopropionate Methyl N2-m-toluenesulfono-N3-[3-(4- cyanophenyl)isoxazolin-5R-ylacetyl]-S-2,3- diaminopropionate (prepared as in example 473 part C above) (0.098g, 0.0002mol) was stirred with isopropyl alcohol (0.018ml, 0.0002mol) and sulfuric acid (5ml) for 12 hours. The reaction mixture was poured over ice and diluted to three times its' volume with water. The title compound was filtered as a pale brown solid. ^H NMR (CDCI3) δ: 7.79-7.61(m, 6H) ; 7.38-7.36(m, 2H) ; 6.49- 6.40(m, IH) ; 6.01-5.99 (m, IH) ; 5.62-5.55(m, IH) ; 5.19- 5.08( , IH) ; 4.31-4.28(m, IH) ; 4.11-3.99 (m, IH) ; 3.56(s, 3H); 3.72-3.48(m, 4H) ; 3.24-3.16(dd, IH, J=7.3, 17.0); 2.41(s, 3H) ; 1.29-1.27(d, 6H, J=6.59Hz) . MS(ESI) calc'd for C 26 H 32 N 4 SO 7 545.3 found 545.2 (M+H) + Example 954 N2.-3- (n-butvlcarbamovl) -N 3 -- \ 3 - (4-amidophenvl) isoxazolin- 5R-vlacetvll -S-2. -diaminopropionic acid Following the procedure outlined for example 1945 above, Methyl ^-3- (n-butylcarbamoyl) -N 3 - [3- (4- cyanophenyl)isoxazolin-5R-ylacetyl] -S-2,3- diaminopropionate (0.87g, 0.002mol) gave a 66% yield of N^-3- (n-butylcarbamoyl) -N - [3- (4-amidophenyl) isoxazolin- 5R-ylacetyl] -S-2,3-diaminopropionic acid. IH NMR (CDCΪ3) δ: 12.7 (bs, IH) ; 8.12-8.09 and 7.28-7.26 (2m, IH) ; 8.05 and 7.43(2s, IH) ; 7.94-7.92(d, 2H, J=8.54); 7.87(s, IH) ; 7.73-7.70(d, 2H, J=8.5Hz); 6.51-6.49(m, IH) ; 5.02-4.95(m, IH) ; 3.95-3.90 (m, IH) ; 3.58-3.47 (m, 2H) ; 3.29-3.13 (m, 2H) ; 2.72-2.38(m, 4H) ; 1.52-1.46(m, 2H) ; 1.34-1.25(m, 2H) ; 0.87-0.85(t, 3H, J=4.3Hz) . MS(ESI) : Cacl'd for C20H26N4O7 435.2 found 435.2 (M+H) + . Example 956 N2.-3-methvlphenvlsulfonvl-N3-- f3- (4-amidophenvl) -5R- vlacetvll -S-2.3-diaminopropionic acid Part A: Methyl N2-m-toluenesulfono-N3- [3- (4- amidophenyl) -5S-ylacetyl] -S-2,3-diaminopropionate hydrochloride. Methyl N2-m-toluenesulfono-N3- [3- (4-cyanophenyl) -5R- ylacetyl] -S-2,3-diaminopropionate (0.19g, 0.00039mol) was dissolved in 10ml concentrated sulfuric acid. After stirring for 12 hours the reaction mixture was poured over lOg of ice and 20ml of water was added. The white solid was filtered, washed once with water and dried under vacuum overnight to give methyl- ^-m-toluenesulfono-N - [3- (4-amidophenyl) -5S-ylacetyl] -S-2,3-diaminopropionate as a white powder. IR(neat) cm "1 : 3404, 3340, 3274, 3202, 2930, 1710, 1652, 1612, 1526, 1320, 1286, 1238, 1174, 1100, 1086, 1070, 886, 850, 614, 574. MS(ESI): calc'd for 23H26 407S 503.2 found 503.3 (M+H)+. Part B: N 2 -m-toluenesulfono-N 3 -[3-(4-amidophenyl)-5R- ylacetyl]-S-2,3-diaminopropionic acid Methyl N^-m-toluenesulfono-N 3 -[3-(4-amidophenyl)-5R- ylacetyl]-S-2,3-diaminopropionate hydrochloride (0.146g, 0.29mmol) was dissolved in MeOH (5ml), LiOH (0.013g, 0.32mmol) in H2O (5ml) was added and the reaction mixture left to stir overnight. Purification was done by HPLC on a Vyade column using a gradient of 0.05%TFA/water to 0.05%TFA/acetonitrile over 45min. The flow was set to lOml/min and the detector at 254nm. The peak eluted at 25min, the volatiles were evaporated in vacuo, and the solid dried under vacuum. MS(ESI) calc'd for C22H24N4O7S: 489.2 found: 489.2. Example 978 Methvl N^- -toluenesulfono-Nl-T3-(5-amidopvrid-2- vl)isoxazolin-5S-vlacetvll-S-2.3-diaminopropionate mp 192-195.5°C (dec). NMR (DMSO-d6, 300 MHz) δ 2.28 (dd, J=14.6, 7.0 Hz, IH) , 2.36 (s, 3H) , 2.44-2.54 (m, IH, under DMSO), 3.04-3.15 (m, IH) , 3.20 (dd, J=17.6, 7.3 Hz, IH) , 3.30-3.40 (m, IH, under water), 3.53 (dd, J=17.6, 10.6 Hz, IH), 3.80-3.89 (m, IH) , 4.92-5.05 (m, IH) , 7.38- 7.48 (m, 2H) , 7.54-7.61 (m, 2H) , 7.68 (br s, IH) , 7.98 (d, J=8.1 Hz, IH) , 8.04-8.10 (m, 2H) , 8.23 (br s, IH) , 8.27 (dd, J=8.1, 2.2 Hz, IH) , 9.06 (d, J=1.5 Hz, IH) , 12.76 (br s, IH) . IR (KBr) 3388, 3314, 3274, 3186, 1712, 1662, 1584, 1546, 1418, 1344, 1160, 934, 794, 712, 688, 620, 576 cm -1 . MS (ESI) 490 (M+H, 100). Example 979 Nl-f (p-ethyl)phenylsulfonyll-N -r3-(4- carboxamidophenvl)isoxazolin-5-(R.S) -vlacetvl1- ( )-2.3- diaminopropionateSEl01 ! HN R (DMSO) δ 8.12(2H,m), 7.94(2H, d, J=8.423Hz), 7.74(2H, m) , 7.70(2H, d, J=8.423Hz), 7.46(1H, s),7.40(2H, m) , 4.94(1H, m) , 3.92(1H, m) , 3.56(2H, m) , 3.37(3H, m) , 2.70(2H, m) , 2.45 (3H, m) , 1.22 (3H, m)ppm; MS (ESI) m/z 503.3 (M+H) + . Example 996 N 2 --o-toluenesulfonvl-Nl-T5- ( -amidinophenyl)isoxazolin- 3 (R.S)-vlformvll-(S)-2.3-diaminopropionic acid TFA S≤]J^Sel30 Standard cycioaddition techniques using ethylchlorooximido acetate(Aldrich) and 4-cyanostyrene agfforded the desired precursor ethyl-5- (4-cyanophenyl)-isoxazoline carboxylate. Saponification followed by coupling with methyl N^-o- toluylsulfonyl-(S)-2,3-diaminopropionate via standard techniques afforded the desired cyanoprecursor. Formation of the amidine via standard Pinner reaction conditions afforded the desired compound as colorless crystals after HPLC purification; M.P. 84-86°C; iHNMRfDMSO d6) δ: 9.45(b, IH) , 9.35(b, IH) , 8.40(q, IH) , 8.21(dd, IH) , 7.81(t,2H), 7.77( d, J=8.5Hz, 2H) , 7.55(d, J=8.5Hz, 2H) , 7.38-7.49(t, IH) , 7.25(m, 2H) , 5.83(m, IH) , 3.89(q, IH) , 3.23-3.71(m, 3H) , 2.98(q, IH) , 2.57 (s,3H)ppm; ESI mass spectrum 474 (M=H, 100 free base) ; HRMS calcd for C 21 H 24 5 O 6 S 474.144731, found 474.143847. Example 1540 2-(n-Butvloxvcarbonvlamino)-3-T3-(4-amidinophenyl)-1-oxo- 2.8-diazaRpiror4.51dec-2-en-8-vllpropionic acid bis trifluoroacetic acid salt Part A: 3- (4-Cyanophenyl)-8-benzyloxycarbonyl-l-oxo-2.8- diazaspiroT4.51dec-2-ene. The title material was prepared from 4- cyanobenzaldoxime (7.0 g, 48 mmol) and 1- benzyloxycarbonyl-4-methylenepiperidine (De Amici, M. ; Frølund, B.; Hjeds, H. Krogsgaard-Larsen, P. Eur. J. Med. Chem. 1991, 26, 625) (11.0 g, 48 mmol) as described in Example 4, Part B. The crude adduct was purified by flash chromatography using a gradient hexane/ethyl acetate solvent system, starting with hexane and progressing to 65 % ethyl acetate/hexane in 5 % increments to give 14.4 g (86 %) of a pale yellow gum. λ E NMR (DMSO-d δ , 300 MHz) δ 7.75 (d, J=8 Hz, 2H) , 7.69 (d, J=8 Hz, 2H) , 7.37-7.29 (m, 5H) , 5.15 (s, 2H) , 3.95-3.83 (m, 2H) , 3.51-3.44 (m, 2H) , 3.09 (s, 2H), 2.00-1.89 (m, 2H) , 1.83-1.70 (m, 2H) . IR (KBr) 2228, 1698 cm" 1 . HRMS (DEP, NH 3 ) Calc. for (M+H)+: 376.1661. Found: 376.1646. Part B: 3- (4-Amidinophenyl)-l-oxo-2.8-diazaspiroT4,51dec- 2-ene flihydrpchloric acid salt, The intermediate of Part A (4.18 g, 11.1 mmol) was subjected to standard Pinner conditions to give a crude amidine-amine salt, which was purified by flash chromatography using a graduated solvent system starting with chloroform and progressing to 30 % methanol in chloroform to give 1.8 g (48 %) of the title compound. ^-H NMR (DMSO-dβ, 300 MHz) δ 9.56 (br s, 1.5H), 9.36 (br s, 1.5H), 7.95 (d, J=8.7 Hz, 2H) , 7.86 (d, J=8.4 Hz, 2H) , 4.15-4.14 (m, IH) , 3.43 (s, 2H) , 3.36 (s, 4H) , 2.05-2.04 (m, 4H) . HRMS (DEP, NH 3 ) Calc. for (M+H) + : 259.1559. Found: 259.1562. p art C: Methyl 2- (R, s)-(kenyloxycarkony amino)-3- \3 -(4- amidinophenvl)-l-oxo-2.δ-diazaspiroU.51deo-2-en-8- vllpropionate dihvdroiodic acid salt. The intermediate of Part B (1.67 g, 5.0 mmol) was dissolved in dimethylformamide (20 mL) and sodium bicarbonate (1.27 g, 15.1 mmol) was added. A solution of N-benzyloxycarbonyl-3-iodo-L-alanine methyl ester (Marki, w.; Schwyzer, R. Helv. Chim . Acta 1975, 58, 1471) (2.0 g, 5.5 mmol) in dimethylformamide (6 mL) was added and the mixture was stirred at room temperature for 7 d. The solvent was evaporated and the residue was flash chromatographed using a graduated solvent system starting with chloroform and progressing to 20 % methanol/chloroform in 5 % steps to give 1.78 g of impure material. It was chromatographed a second time as above to give 1.72 g (45 %) of pure material. 1 H NMR (DMSO-dβ, 300 MHz) δ 9.16 (br s, 4H) , 7.87 (s, 4H) , 7.71 (d, J=7.7 Hz, IH), 7.39-7.30 (m, 5H) , 5.10-5.05 (m, 2H) , 4.29-4.27 (m, IH) , 3.65 (s, 3H) , 3.23 (s, 2H) , 2.66-2.60 (m, 4H) , 2.46 (m, 2H), 1.75 (m, 4H) . IR (KBr) 3300-2950 (br) , 1718, 1674 cm -1 . HRMS (FAB, glycerol) Calc for (M+H) + : 494.2403. Found: 494.2401. Part D: Methvl 2- (R. S)-amino-3-T3-(4-amidinophenyl) -1- oxo-2.8-diazaspiror4.51 ec-2-en-8-vllpropionate trihvdrobromic acid salt. The intermediate of Part C (1.2 g, 1.6 mmol) was dissolved in 30 % hydrogen bromide in acetic acid (10 mL) and the solution was stirred at room temperature for 17.5 h. The mixture was diluted with ether and filtered. The solid was washed with ether and dried to give 0.872 g (89 %) of a gray solid. λ H NMR (DMSO-dβ + TFA-d, 300 MHz) δ 9.43 (s, 2H), 9.14 (s, 2H) , 7.94-7.85 (m, 4H) , 4.84 (m, IH) , 3.84 (s, 4H) , 3.55-3.42 (m, 6H) , 2.16 (br m, 4H) . MS (ESI) 360 (M+H) . Part E: Methvl 2-(n-butvloxvcarbonvlamino)-3-f3-(4- amidinophenvl)-l-oxo-2.8-diazaspiror4.51dec-2-en-8- vllpropionate hydrobromic acid salt. n-Butylchloroformate (45 μL, 0.35 mmol) was added to a solution of the intermediate of Part D (0.200 g, 0.33 mmol) and triethylamine (0.14 mL, 1.0 mmol) in dimethylformamide (2 mL) and the mixture was stirred at room temperature for 2 h. The solution was flash chromatographed using a gradient solvent system starting with chloroform and progressing to 20 % methanol/chloroform in 5 % steps to give .249 g of the title compound. MS (ESI) 460 (M+H) . Part F: 2-(n-Butvloxvcarbonvlamino)-3-T3-(4- amidinophenyl)-1-QXP-2,8-diazaspiror4,51flec-2-en-8- ynprppionic acid bis trifluoroacetic acid salt. The intermediate of Part E (229 mg, 0.33 mmol) was dissolved in methanol (7 mL) and water (7 mL) and lithium hydroxide hydrate (33 mg, 0.79 mmol) . The mixture was stirred at room temperature for 24 h and additional lithium hydroxide hydrate (18 mg, 0.43 mmol) was added. The mixture was stirred for 24 h and the methanol was evaporated. The aqueous residue was diluted with trifluoroacetic acid (0.15 mL) and the mixture was purified by Prep HPLC as described in Example 514A, Part B to give 31 mg (11 %) of the title compound. 1 H NMR (DMSO- dβ , 300 MHz) δ 9.40 (br s, 2H) , 9.12 (br s, 2H) , 7.91-7.86 (m, 4H), 7.61 (br, IH) , 6.56 (br, IH) , 4.44 (br, IH) , 4.00 (t, J=6.2 Hz, 2H) , 3.38 (m, 6H, under water peak) , 2.03 (br, 4H), 1.58-1.54 (m, 2H) , 1.36-1.34 (m, 2H) , 0.90 (t, J=7.4 Hz, 3H) . HRMS (FAB, glycerol) Calc. for (M+H) + : 446.2403. Found: 446.2394. Example 1541 2- (R. S) - (3-methvlphenvlsulfonvlamino)-3-r3- (4- amidinophenvl)-l-oxo-2.8-diazaspiror4.51dec-2-en-8- vllpropionic acid bis trifluoroacetic acid salt Part A: Methvl 2- (R. S) -(m-toluenesulfonvlamino)-3-L3-(4- amidinophenvl)-l-oxo-2.8-diazaspiroT4.51dec-2-en-8- yllpropionate hydrobromic acid salt. jn-Toluenesulfonyl chloride (63 mg, 0.33 mmol) was added to a mixture of the intermediate in Example SPl, Part D (0.200 g, 0.33 mmol) and triethylamine (0.14 mL, 1.0 mmol) in dimethylformamide (2 mL) and the mixture was stirred at room temperature for 19 h. Additional m- toluenesulfonyl chloride (14 mg, 0,07 mmol) was added and the mixture was stirred for 24 h. The solution was flash chromatographed using a graduated solvent system starting with chloroform and progressing to 30 % methanol/chloroform to give 0.309 g of a tan solid. HRMS (FAB, glycerol) Calc. for (M+H) + : 514.2124. Found: 514.2137. Part B: 2 - (R. S) - (m-Toluenesulfonvlamino) -3- \3 - (4- amidinophenvl)-l-oxo-2.8-diazaspiror4.51 ec-2-en-8- vllpropionic acid bis trifluoroacetic acid salt. The intermediate of Part A ( 0 .211 g, 0.46 mmol) was suspended in 6M hydrochloric acid and the mixture was stirred at room temperature for 2 d. The mixture was concentrated and the residue was purified by Prep HPLC as described in Example 514A, Part B to give 16 mg of the title compound. HRMS (FAB, glycerol) Calc. for (M+H) + : 500.1968. Found: 500.1956. Example 1552 5 (R. S) - (2-Piperidin-4-vl)ethvl-8- (3-carboxvpropvl) -1-oxa- 2.8-diazaspiror4.41non-2-ene-7.9-dione This material was prepared using the procedures outlined in Example 189, giving the title compound; mp: 133.4-135.1 * C; H NMR (400 MHz, CD 3 OD, 55 * C) δ 3.59 (t, J = 6.8 Hz, 2H) , 3.50 (d, J = 17.7 Hz, IH) , 3.38 (bd, J = 12.9 Hz, 2H), 3.18 (d, J = 17.7 Hz, IH) , 2.98 (m, 4H) , 2.85 (m, 2H) , 2.50 (m, IH, coincident with DMSO-ds), 2.45 ( , 2H) , 2.31 (t, J = 7.1 Hz, 2H) , 2.00 (m, 2H) , 1.98 (pentuplet, J = 7.1 Hz, 2H) , 1.40 (m, 2H) . Example 1585A Nl-n-butvloxvcarbonvl-N 3 — L3- (4-pjperidinvlmethvl) - isoxazolin-5- (R.S) -vl-acetvll - (S) -2.3-diaminopropionic acid TFA salt. i HNMR (DMSO) δ 8.5(1H, brd), 8.2 (IH, brd), 8.0(1H, m) , 7.4(1H, d) , 4.7(1H, m) , 3.9(3H, m) , 3.6(1H, m) , 3.25(2H, m) , 3.K3H, m) , 2.9(2H, m) , 2.7(lH, m) , 2.4(2H, m) , 2.2(3H, m) , 1.8(2H, m) , 1.7(1H, m) , 1.5(2H, m) , 1.3 (4H, m) , 0.9(3H, t)ppm; ESI mass spectrum 427.1 (M+H) + free base.sc577 Example 1603 Methvl N^-n-butvloxvcarbonvl-Ni-T3-(4-piperidinvlpropvl)- isoxazolin-5(R.S)-vl-acetvll-(S)-2.3-diaminopropionate TFA salt, ÷ J -HNMR (CDCI 3 ) δ6.29(lH, brd), 4.9 (IH, m) , 4.45(IH, m) , 4.05(2H, m) , 3.78(3H, s) , 3.68(lH, m) , 3.5(3H, m) , 3.K1H, m) , 2.96(2H, m) , 2.78(1H, m) , 2.55(2H, m) , 2.36(2H, m) , 1.95(2H, m) , 1.6(6H, m) , 1.5(2H, m) , 1.35(5H, m) , 0.94(3H, m) ppm; ESI mass spectrum 455 (M+H) + free base.xw923 Example 1609 Methvl N 2 --p-toluenesulfonvl-Nl-T3-(4-pjperidinvlpropvl)- isoxazolin-5-(R.S)-vl-acetvll -(S)-2. -diaminopropionate TFA salt.sc569 ^-HNMR (CDCI3) δ7.7(2H, d) , 7.3(2H, d) , 7.18(1H, m) , 6.4(1H, m) , 4.92(1H, m) , 4.0(2H,m), 3.7(lH, m) , 3.58(3H, d) , 3.35(2H, m) , 3.K1H, m) , 2.9(2H, m) , 2.75(1H, m) , 2.55(1H, m) , 2.4(6H, m) , 1.9(2H, m) , 1.6(5H, m) , 1.35(2H, m)ppm; ESI mass spectrum 509.3 (M+H) + free base Example 1619 N2-(2-methylphenylsυl£onyl)-N -T3-(4-pjperidinylethyl)- isoxazolin-5-(R.S)-vlacetvl)-(S)-2.3-diaminopropionic acid TFA salt. ^-HNMR (DMSO)δ: 8.5(IH, m) , 8.18(IH, m) , 8.05(IH, m) , 7.79(1H, d J=8.057Hz), 7.5K1H, t, J=6.958 & 7.324Hz), 7.37(2H, m) , 4.65(1H, m) , 3.83(1H, m) , 3.4(lH, m) , 3.27(3H, m) , 3.07(1H, m) , 2.84(2H, m) , 2.68(lH, m) , 2.59(3H, s) , 2.4(1H, m) , 2.32(3H, m) , 2.08(lH, m),1.83(2H, m) , 1.45 (3H, m) , 1.26 (2H, m)ppm; ESI mass spectrum 481.4 (M+H, 100)+ free base. se632 Example 1621 N^-p-toluenesulfonvl-N 3 -- T3- (4-pjperidinvlethvl) - isoxazolin-5- (R.S) -vlacetvl1 - (S) -2.3-diaminopropionic acid TFA salt.sc57 i HNMR (DMSO) δ 7.73(2H, d) , 7.35(2H, d) , 4.85(2H, m) , 4.05(1H, m) , 3.63 (IH, m) , 3.2(2H, m) , 3.0(4H, m) , 2.6(lH, m) , 2.4(3H, s), 2.42(2H, m) , 2.0(2H, m) , 1.7(lH, d) , 1.6(3H, ) , 1.4 (3H, m)ppm; ESI mass spectrum 481 (M+H, 100) + free base Example 1622 N2- (2-bromophenvlsulfonvl) -N 3 -- \ 3- (4-pjperidinvlethvl) - isoxazolin-5- (R.S) -vlacetvll - (S) -2. -diaminopropionic acid TFA salt. , 1 HNMR (DMSO)δ: 8.5 (IH, brd), 8.2 (IH, m) , 8.1 (IH, m) , 7.95QH, m) , 7.8(1H, m) , 7.5(2H, m) , 4.7(lH, m) , 3.9(1H, m) , 3.4(1H, m) , 3.25(2H, m) , 3.2(1H, m) , 3.0(1H, m) , 2.8(2H, m) , 2.7(1H, m) , 2.4(2H, m) , 2.3(2H, m) , 2.2(lH, m) , 1.8 (2H, m) , 1.5 (2H, m) , 1.2 (2H, m)ppm; ESI mass spectrum 545.2 (M+H, 100) + free base. se631 Example 1623 N2- (3.5-dimethylisoxazovlsulfonvl) -N 3 -- \3 - (4- pjperidinvlethvl) -isoxazolin-5- (R.S) -vlacetvll - (S) -2.3- diaminopropionic acid TFA salt. 1 ΗNMR (DMSO)δ: 8.5(1H, d) , 8.08(1H, m) , 4.65(1H, m) , 3.9(1H, m) , 3.4(1H, m) , 3.25(3H, m) , 3.15(2H, m) , 2.85(2H, m) , 2.7(1H, m) , 2.52(3H, s) , 2.4(lH, m) , 2.3(3H, m) , 2.2(3H, m) , 1.8(2H, brd, d) , 1.45(3H, m) , 1.25(2H, m)ppm; ESI mass spectrum 486.3 (M+H, 100)+ free base. se634 Example 1624 N2-(3.4-dimethylthiazoylsulfonyl)-Nl-T3-(4- pjperidinvl thvl)-isoxazolin-5- (R.S) -vlacetvll-(S)-2.3- diaminopropionic acid TFA salt. 1 HNMR (DMSO)δ: 8.6(IH, d) , 8.45(lH, brd), 8.K1H, m) , 4.65(1H, m) , 3.9(lH, m) , 3.5(4H, m) , 3.05(2H, m) , 2.9(3H, m) , 2.6(3H, s), 2.45(3H, s) , 2.4(5H, m) , 1.8(2H, brd. d) , 1.5(2H, m) , 1.2(2H, m)ppm; ESI mass spectrum 502.4 (M+H, 100)+ free base. sel04 Example 1625 N2-n-butvlsulfonvl-Nl- \3 -(4-pjperidinvlethvl)-isoxazolin- 5-(R,S)-ylacetyl1-(S)-2,3-diaminopropionic acid TFA salt.sc576 1 HNMR (DMSO) δ 8.5(1H, m) , 8.2(2H, m) , 7.55(1H, m) , 4.7(1H, m) , 3.9(1H, m) , 3.4(1H, m) , 3.2(3H, brd,d), * 3.K1H, m) , 2.98(2H,m), 2.9(4H, m) , 2.4QH, d) , 2.3(3H, m) , 1.8(2H, brd, d),1.7(2H, m) , 1.5(6H, m) , 0.9(3H, t)ppm; ESI mass spectrum 447.3 (M+H, 100) + free base Example 1627 isoxazolin-5- (R.S)-vl-acetvll-(S)-2.3-diaminopropionic acid TFΛ salt 1 MR (DMSO) δ 8.5 (IH, m) , 8.2 (2H, brd),7.3(lH, m),4.7(lH, m) , 4.05(lH, m) , 3.9(2H, t) , 3.5(1H, m) , 3.2(3H, brd,d), 3.0(lH, m) , 2.8(2H, m) , 2.7QH, m) , 2.4(1H, d) , 2.25(3H, m),1.8(2H, d) , 1.6(6H, m) , 1.4(7H, m) , 0.9(3H, t)ppm; ESI mass spectrum 441.3 (M+H, 100)+ free base. sc574 Example 16 1 Nl-p-toluenesulfonvl-N 3 --T3-(4-piperidinvlpropvl)- isoxazolin-5-(R.S)-vlacetvll-(S)-2. -diaminopropionic acid TFA salt.sc572 i HNMR (CD 3 OD)δ: 7.7(2H, m) , 7.35(2H, m) , 4.85(1H, m) , 4.05(2H, ) , 3.72(1H, m) , 3.66(2H, m) , 3.56(1H, m) , 3.35(2H, m) , 3.25(1H, m) , 3.14(1H, m) , 2.94(2H, m) , 2.84(1H, m) , 2.55(1H, m) , 2.4(3H, m) , 2.35(3H, m) , 1.95(2H, m) , 1.62 (3H, m),1.32(4H, m) ,ppm; ESI mass spectrum 495.3 (M+H) + free base Example 1656 N^-m-toluenesulfonvl-N -T3-(4-amidinopiperidinvl)- isoxazolin-5- (R.S)-vlacetvll-(S)-2.3-diaminoproprionic acid se534 M.P. 70-74°C; ^-H NMR (DMSO-d6) δ 8.13 (m,2H), 7.58(m,2H), 7.44-7.38 (m, 5H) , 4.74 (m,lH), 3.88-3.80 (m, 5H) , 3.40 (m,lH), 3.14-2.99 (m,4H), 2.74 (m,2H), 2.37 (s,3H), 2.17 (dd, J=7.32,14.28 Hz), 1.88 ( d,J=13.18 Hz, 2H) , 1.53 (q, J=11.35 Hz, 2H) ppm; High Res Mass Spectrum calculated (M+H) + 495.202580;found (M+H) + 495.200904. Example 1657 isoxazolin-5- (R.S)-vlacetvl1-(S)-2.3-diaminoproprionic acid Part A: The isoxazoline acetic acid was prepared starting from l-t-butylcarbamate-4-piperidine carboxaldehyde (Jacobs, R.,et al, EP 532177) through methods previously described. ^-E NMR (CDCI3) δ 4.94 (m, IH) , 4.18- 4.05 (m, 2H) , 3.18 (dd, J=10.25,17.20 Hz, IH) , 2.90-2.67 ( , 4H) , 2.63 (m, 2H) , 1.87 (m, 2H) , 1.56-1.45 (s, 9H) , 1.46 (s, 9H) ppm; Mass Spectrum (NH3-CI) m/z (M+NH4)+ 330 (100%); IR (KBr) 3100, 1734, 1690, 1648, 1430, 1276, 1168, 758 cm ~ l . Part B: The acid from Part A (360 mg, 1.2 mmol) was coupled with methyl L-N^-p-toluylsulfonyl- diaminoproprionate using procedure described in Example 43D. The crude product was chromatographed on silica gel (2% MeOH/CH2Cl2) to afford 270 mg (41%) of a white foam. M.P. 55-60°C; !H NMR (CDCI3) δ 7.72 (d, J=8.06 Hz, 2H) , 7.30 (d, J=8.06 Hz, 2H) , 6.45 (m, IH) , 5.73 (dd, J=8.42,16.11 Hz, IH) , 4.90 (m, IH) , 4.13 (m, 2H) , 4.01 (m, IH) , 3.58 (s, 3H) , 3.60-3.49 (m, 2H) , 3.10 (m, IH) , 2.84- 2.72 (m, 3H) , 2.57 (m, 2H) , 2.48 (m, IH) , 2.42 (s, 3H) , 1.85 (d, 2H) , 1.55-1.46 (brd m, 2H) , 1.46 (s, 9H)ppm; Mass Spectrum (NH3-CI) m/z (M+NH4) + 584 (100%); IR (KBr) brd 3300, 1746, 1688, 1428, 1238, 1164 cm "1 . Part C: To the product from Part B (230 mg, 0.41 mmol) was added 10 ml of 30% TFA/CH2CI2 and the mixture was stirred for 3h. The solvents were removed in vacuo . To the residue was added 2 ml DMF, triethylamine (0.39 ml, 2.8 mmol), and bis-tertbutyloxycarbonyl-3,5- dimethylpyrazole-1-carboxamidine (165 mg, 0.49 mmol) (Kim, et al, Tet. Lett.,1993, 3A, 7677) and the mixture was stirred for 24h. The reaction was partitioned with EtOAc/water. The organic layer was washed successively with water, brine and dried (MgS04). Chromatography on silica gel (2% MeOH/CH2Cl2) afforded 203 mg (71%) of a white foam. M.P. 69-75°C; ^-H NMR (CDCI3) δ 10.18 (brd m, IH) , 7.72 (d, J=8.05 Hz, 2H) , 7.30 (d, J=8 Hz, 2H) , 6.40 (m,lH), 5.65 (m, IH) , 4.87 (m, IH) , 4.30 (brd, IH) , 4.05 (brd, IH) , 3.60-3.51 (s+m, 5H) , 3.09 (m, 3H) , 2.78 (m, 3H) , 2.42 (s, 3H) , 1.89 (m, 2H) , 1.73 (m, 2H) , 1.63 ( brd m, 2H) , 1.49 (s, 18H)ppm; Mass Spectrum (ESI) m/z (M+H)+ 709.5 (100%); IR (KBr) 3300-2800, 2210, 1742, 1660, 1600, 1546, 1446, 1332, 1162, 1092 cm" 1 . Part D: To the product from Part C (160 mg, 0.23 mmol) was added 6 ml of 1:1 MeOH/water and lithium hydroxide (28 mg, 0.67 mmol). The mixture was stirred for 18h and the solvents were removed in vacuo. The residue was taken up in water and acidified with IN HCI and extracted with EtOAc. The organic layer was dried (MgS04), filtered and concentrated to afford 118 mg (76%) of the acid. To the acid was added 10 ml 30% TFA/CH2CI2 and the mixture was stirred 24h. The solvents were removed and the TFA salt was purified by HPLC to afford 20 mg product. M.P. 134-140°C; iHNMR (DMSO-d6) δ 7.9 (q,lH), 7.66 (d,j=8.06 Hz, 2H) , 7.46 (s, 3H) , 7.36 (d,j=8.06 Hz, 2H) , 4.72 (m,lH), 3.80 (d, j=13.18 Hz, 2H) 3.61 (m,lH), 3.41-3.18 ( , 5H) , 3.13-2.99 (m,3H), 2.75 (m 2H) , 2.36 (s,3H), 2.22 (m, IH) , 1.88 (d, j= 12.8Hz, 2H) , 1.53 (m, 2H) ppm ; Mass spectrum (ESI) m/z 495.2 (100%), high res Mass Spectrum (M+H) + calculated 495.20258, found 495.202476 Example 1 7 N^-p-toluenesulfonvl-N^.-T3-(4-amidinopjperidinvlmethvl)- isoxazolin-5-(R.S)-vlacetvll-(S)-2.3-diaminopropionic acid TFA salt, *HNMR (DMSO)δ: 8.K2H, m) , 7.65(2H, d) , 7.35(2H, d) , 4.7(1H, m) , 3.8(3H, ) , 3.4(2H, m) , 3.K1H, m) , 3.0(3H, m) , 2.7(1H, m) , 2.4(1H, m) , 2.35(3H, s) , 2.25(1H, m) , 2.2(3H, m),1.85(lH, m),1.7(2H, m) , 1.6(1H, m) , 1.2(3H, m)ppm; ESI mass spectrum 509.4 (M+H, 100) + free base. sel03 Example 1704 N^-n-butvloxvcarbonvl-N - 3 -(σuanidinopropyl)-isoxazolin- 5-(R.S)-vlacetvll-(S)-2.3-diaminopropionic acid TFA salt. Part A: The title compound was prepared following the [3+2] cycioaddition methodology employed for example 4 from the readily accessible Boc-aminopropylchlorooxime (obtained from a sequence of steps from commerical (Aldrich) aminopropanol (aldehyde obtained via Moffat et. al. J.C.S. Perk. Trans. 1. 1991, 5, 1041-1051)) and butylvinyl ester. LiOH saponification in methanol:water (9:1), then afforded the desired acetic acid compound in 90% yield. 1 ENMR (CDCI3) δ: 4.90(m, IH) , 4.70(brd, s, IH) , 3.08(m, 3H) , 2.68(m, 2H) , 2.57(dd, IH) , 2.34(t,2H), 1.75(m, 2H) , 1.41(s, 9H)ppm; ESI mass spectrum 287 (M+H, 100) .sd266 Part B: The product from part A was then coupled to methyl N^-n-butyloxycarbonyl-(S)-2,3-diaminopropionate via the procedure used in example 4, to obtain Methyl N^-n- butyloxycarbonyl-N 3 -[3- (Boc-aminopropyl)isoxazolin-5- (R,S) -ylacetyl]-(S)-2,3-diaminopropionate in 50% yeild. Treatment with trifluoroaceticacid in dichloromethane, evaporation of solvent then afforded the anilino intermediate as the TFA salt. Standard guanidine formation techniques then afforded the di- Bocguanidinopropyl analog in 90% yield. Removal of the Boc-protecting groups with TFA afforded example 601 as the TFA salt. Alternatively, saponification of the methyl ester followed by removal of the Boc-protecting groups with TFA also afforded the desired product as the TFA salt in 80% overall yield. * H NMR (CD3OD) δ: 4.93 (m, IH) , 4.29(brd.m, IH) , 4.02(t, 2H) , 3.65(m, IH) , 3.32(m, IH) , 3.21(m, 2H) , 3.09(dd, J=10.2 &17.6HZ, IH) , 2.79(dd, J=7.32 &17.1HZ, IH) , 2.52(dd, J=2.2& 8.8Hz, IH) , 1.84(m, 2H) , 2.39(m, 3H) , 1.58(m, 2H) , 1.36(m, 2H) , 0.9 (t,3H, )ppm; HR MS calcd. for ESI mass spectrum 529 (M+H, 100) for free base. sc761 Example 1756 N2-p-toluvlsulfonvl-N 3 -f3-(4- piperidinvlmethvlaminocarbonvl)-isoxazolin-5-(R.S)- vlacetvll-(S)-2. -diaminoproprionic Acidse5 3 Part A: To a mixture of tert-butyl vinylacetic acid (11.2 g, 0.079 mol) and ethylchlorooximidoacetate (11.37 g, 0.075 mol,Aldrich) in a mixture of 2:1 THF/water at 0°C was added sodium bicarbonate (19.9 g, 0.237 mol). The reaction was stirred for 3d at room temperature, the layers were separated and the aqueous layer was extracted with EtOAc. The combined organic layers were washed with brine and dried with MgS04. The crude oil was chromatographed on silica gel (7:1 hexanes/ EtOAc) to afford 7.46 g (39%) of product as a colorless oil; ^H NMR (CDCI3) δ 5.15 (m, IH) , 4.39 (q, J=7.32 Hz, 2H),3.43 (dd,J=10.99,17.58 Hz, IH) , 3.03 (dd, J=7.69,17.58 Hz, IH) , 2.81 (dd,J=5.86,16.11 Hz, IH) , 2.59 (dd,J=7.69,16.11 Hz, 1H),1.46 (s, 9H) , 1.39 (t,J=7.32 Hz, 3H) ; Mass Spectrum (NH3-CI) m/z (M+H) + 258 (12%), (M+NH4) + 275 (100%). Part B: The ethyl ester (3 g, 0.012 mol) from Part IA was selectively hydrolyzed with LiOH (0.64 g, 0.015 mol) in 1.5:1 methanol/ water at O^C for 1.5h. The methanol was removed in vacuo. The aqueous residue was acidified with 10% citric acid and extracted with EtOAc and dried with MgS04. The crude solid was recrystallized with CH2CI2/ hexanes to afford 2 g (75%) white crystals, mp 83-86°C; ^-H NMR (CDCI3) δ 5.23 (m, IH) , 3.44 (dd, J=10.98,17.58 Hz, IH) , 3.05 (dd, J= 8.05,17.95 Hz, IH)r 2.82 (dd, J=5.85,16.11 Hz, IH) , 2.64 (dd, J=7.32,16.11 Hz, IH) , 1,46 (s, 9H)ppm; Mass spectrum (NH3-CI) m/z (M+NH4) + 247 (90%). Part C: 4-Aminomethyl piperidine (3.8 g, 0.034 mol, Aldrich) was selectively protected in 68% yield with carbobenzoxyimidazole using the method of Sharma, et al. (J. Med. Chem. 1989, 32., 357). To the crude 4-Cbz- aminomethyl piperidine (3 g, 0.012 mol) in 30 ml dioxane at 0^c was added 13 ml of IN sodium hydroxide and di-t- butyl dicarbonate (2.7 g, 0.013 mol). The reaction was stirred at room temperature for 48h. The dioxane was removed in vacuo and the residue was suspended in EtOAc and washed successively with 10% citric acid, sat'd NaHC03, brine and dried (MgS04) . Recrystallization with CH2CI2/ hexane afforded 1 g of white crystals (24%) mp 91- 96°C; E NMR (CDCI3) δ 7.32 (s, 5H) , 5.10( s, 2H) , 4.60 (t, IH) , 4.20 (brd, 2H) , 3.0 (brd, 2H) , 2.75 (brd, 2H) , 1.65 (d, 2H) , 1.45 (s, 9H) , 1.12 (brd, 2H)ppm; Mass spectrum (NH3-CI) m/z (M+H)+ 349 (31%), (M+H-56)+ 293 (100%); IR (KBr) 1698,1530 cm -1 ; Analysis for C19H28N204 calc'd C:65.49, H:8.10, N:8.04; found C:65.78, H:7.82, N:8.06. Part D: To the compound from part C (94 mg, 2.7 mmol) was added 50 ml EtOH and 100 mg of 10% Pd/C and the mixture was hydrogenated at 40 PSI for 18h. Filtration and removal of the solvent afforded 569 mg (98%) solid, mp 84- 88°C; iH NMR (CDCI3) δ 4.70 (brd, IH) , 3.10 (d, 2H) , 3.0 (t, 2H), 2.95 (brd, 2H) , 2.64 (t, 2H) , 1.70 (d, 2H) , 1.46 (s, 9H) , 1.20 (m, 2H) ppm; Mass spectrum (NH3-CI) m/z (M+H) + 215 (100%); IR (KBr) 2972-2800, 1694 cm "1 . Part E: To the acid from Part B (360 mg, 1.6 mmol) in 5 ml EtOAc was added triethylamine (0.67 ml, 4.80 mmol) followed by TBTU (560 mg, 1.73 mmol) . After 15 minutes the amine from Part D (370 mg, 1.7 mmol) was added and the reaction was stirred for 24h. The reaction mixture was washed successively with 10% citric acid, water, sat'd NaHC03 , brine and dried (MgS04) . The residue was chromatogrphed on silica gel (3:2 Hexanes/EtOAc) to afford 0.41 g (61%) white foam. E NMR (CDCI3) δ 5.04 (m, IH) , 4.63 (d, J=13.18 Hz, 2H) , 4.53 (d,J=13.18 Hz, IH) , 3.52- 3.38 (m,' IH), 3.15-2.99 (m, 4H) , 2.77 (m, 2H) , 2.59-2.49 (m, 5H),1.78 (t, J=10.0 Hz 3H) , 1.46 (s, 9H) , 1.44 (s, 9H) , 1.25 (m, 2H) ; Mass Spectrum (NH3-CI) m/z (M+H)+ 426.3 (29%), (M+H-56)+ 370.2 (43%); IR (KBr) 2976, 2930, 1714, 1632, 1592, 1522, 1476,1452,1392, 1366, 1168cm- 1 . Part F: To the product of Part E (380 mg, 0.89 mmol) was added 10 ml of 30% TFA/CH2CI2 and stirred for 4h. The solvents were removed and 10 ml dioxane was added. The mixture was cooled to 0°C and 2 ml of IN NaOH was added followed by di-t-butyldicarbonate (0.22g, 0.98 mmol). The reaction was stirred for 48 h at room temperature. The reaction was concentrated and partitioned with EtOAc and water. The aqueous layer was acidified with 10% citric acid, extracted with EtOAc and dried (MgS04) . The crude residue was chromatographed on silica gel (10% MeOH/CH2Cl2) to afford 0.23 g (69%) of a white foam, mp 159-165°C λ E NMR (DMSO-d6) δ 6.95 (t, J=5.86 Hz, IH) , 4.87 (m, IH) , 4.33 (d, J=13.18 Hz, IH) , 4.09 (d, J=13.90 Hz, IH) , 3.31 (m, IH) , 3.07 (t, J= 12.82 Hz, IH) , 2.99 (dd, J=3.66,8.05 Hz, IH) , 2.93 (dd, J= 3.66, 7.70 Hz, IH) , 2.82 (t, J= 5.86 Hz, 2H) , 2.69 (t, 12.82 Hz, IH) , 2.,39 (m, IH) , 2.27 (dd, J=7.69,14.6 Hz, IH) , 1.67-1.60 (m, 3H) , 1.37 (s, 9H) , 1.04 (t, J=13.5 Hz, lH)ppm; Mass Spectrum (NH3-CI) m/z (M+NH4) + 387 (100%); IR (KBr) 3352, 1692, 1630, 1588, 1518, 1448, 1210, 1176, 1140 cm -1 . Part G: The product of Part F (217 mg, 0.59 mmol) was coupled with methyl L-N^-p-toluylsulfonyl- diaminoproprionate according to procedure in Example 43D. The crude material was chromatographed on silica gel (2% MeOH/CH2Cl2) to afford 230 mg (63%) foam. *H NMR (CDCI3) δ 7.72 (d, 2H) , 7.30 ( d, 2H) , 6.4.0-6.32 (m, IH) , 5.1 ( , IH) , 4.70 (brd, 2H) , 4.50 (d, IH) , 3.99 (brd, IH) , 3.65 (s, 3H) , 3.50 (m, 2H) , 3.15-2.99 (m, 3H) , 2.85-2.55 (m 2H) , 2.45 (s, 3H) , 1.85 (brd, 4H) , 1.46 (s, 9H) , 1.29 (m, 2H)ppm; Mass Spectrum (ESI) m/z (M+H)+ 624.5 (72%), (M+H- 56)+ 568.3 (98%) . Part H: The product of Part G (200 mg, 0.32 mmol) was hydrolyzed with lithium hydroxide (20 mg, 0.48 mmol) in 1:1 MeOH/water for 48h. The solvents were removed in vacuo and the residue dissolved in water, acidified with 10% citric acid, extracted with EtOAc and dried (MgS04). The crude acid was treated with 15 ml of 30% TFA/CH2CI2 for 24h. The crude TFA salt was purified via HPLC to give 21 mg (11%) foamy solid. iHNMR (DMSO-d6) δ8.15 (m,lH), 7.73 (m,lH), 7.63 (d,j=8.06 Hz, 2H) , 7.35 (d,j=8.05 Hz, 2H) , 4.90 (m,lH), 4.37 (d,j=13.5 Hz, 2H) , 4.14 (d,j=2H, j=10.9 Hz), 3.83 (q,j=9 Hz,lH), 3.35 (m,2H), 3.12-2.90 (m,3H), 2.74 (m, 2H) , 2.33 (s,3H), 2.50-2.20 (m, 3H) , 1.90-1.70 (m,4H), 1.35 (m,2H) ppm; High Res Mass Spectrum (M+H)+ calculated 510.202246, found 510.203464. Example 1769 N^-p-toluenesulfonvl-N 3 -- 3- (N- (4-pjperidinvlmethvl) -N- (methvl)aminocarbonyl) -isoxazolin-5- (R. s ) -vlacetvll - (S) - 2.3-diaminoproprionic Acid Trifluoroacetic Acid Saltse536 Part A: To 4-tertButyloxycarbonyl-piperidinyl-methyl amine described previously (1.93 g, 0.009 mol) in 20 ml CH2CI2 at 0°C was added pyridine (1.1 ml, 0.014 mol) followed by slow addition of trifluoroacetic anhydride (1.4 ml, 0.009 mol). The reaction was stirred at 0°C for lh, then it was diluted with CH2CI2 washed successively with 10% citric acid, water, sat'd NaHC03, brine and dried (MgS04) . Recrystallization from CH2CI2/Hexanes afforded 2.4 g (86%) of a bright yellow solid, mp 123-125 °C; ^-H NMR (CDCI3) δ 4.74 (m, IH) , 4.56 (d, J=13 Hz, IH) , 4.0 (d, J= 12 Hz, IH) , 3.14 (m, 3H) , 2.75 (t, J=13 Hz,lH), 1.82 (d, 3H) , 1.45 (s, 9H) 1.28 (m, 2H) ppm; Mass Spectrum (NH3-CI) m/z (M+NH4) + 328 (100%) , (M+NH4 -56) + 272.1 (100%); IR (KBr) 3354, 1686, 1526, 1200, 1140 cm "1 . Part B: To the product of Part A (400 mg, 1.29 mmol) in 2 ml DMF was added NaH (62mg, 1.6 mmol) After lh, methyl iodide (0.1 ml, 1.6 mmol) was added and the reaction was immersed in a 60®C oil bath for 24h. The reaction was cooled and partioned between EtOAc and water. The organic layer was washed with water, brine and dried (MgS04) . The reaction had not gone to completion and was resubjected to the above conditions and after work up afforded 322mg (77%) yellow oil. The crude trifluoroacetate was placed in 20 ml of 1:1 MeOH/ water and K2CO3 (150 mg, 1.1 mmol) was added and the reaction was stirred for 36h. The solvents were removed in vacuo and the residue partioned with EtOAc/water. The aqueous layer was extracted with EtOAc and the combined organic layers were washed with brine and dried (MgS04) , filtered and concentrated to yield 194 mg (89%) oil. ^ NMR (CDC13) δ 3.15 (m, 4H), 2.85 (s, 3H) , 2.80 (brd s, IH) , 2.61 (t, J= 12Hz, 2H) , 1.63 (d, J= 10.6 Hz, 2H) , 1.45 (s, 9H) , 1.25 (m, 2H) , 0.87 (m, lH)ppm; Mass Spectrum (NH3-CI) m/z (M+H) + 229 (100%), (M+NH4) + 246 (15%); IR (KBr) 2924,1696,1160 cm "1 . Part C: The product of Part B (173 mg, 0.76 mmol) was coupled with the acid (from Part B previous example) according to procedure in Example 43D to yield 177 mg (54%) yellow oil. X H NMR (CDCI3) δ 5.02 (m, IH) , 4.59-4.50 (brd.m, 2H) , 3.48 (dd, J= 10.62,17.58 Hz, IH) , 3.15-3.02 (m, 4H) , 2.86 (s, 3H) , 2.77 (m, 2H) , 2.59 (m, IH) , 2.0- 1.91 (brd m, IH) , 1.73 (t, J=11.72 Hz, 2H) , 1.46 (s, 18H) , 1.28 (m, 2H) ppm; Mass Spectrum (NH3-CI) m/z (M+H)+ 440.2 (100%), (M+NH4)+ 457.3 (23%), (M+H-56) + 384.2 (73%); IR (KBr) 2976, 2932, 1730, 1694, 1634, 1162 cm "1 Part D: The product of Part C (170 mg, 0.387 mmol) was deprotected and selectively reprotected as in Part IF to afford a yellow foam. !H NMR (CDCI3) δ 5.10 (m, IH) , 4.60 ( , IH) , 4.50 (m, IH) , 3.50 (m, IH) , 3.12 " (m, 4H) , 2.80 ( s, 3H) , 2.78 (m, IH) , 2.70 (m, 2H) , 1.90 ( brd m, IH) , 1.75 (brd m, 2 H) , 1.45 (s, 9H) , 1.25 (brd m, 2H)ppm; Mass Spectrum (NH3-CI) m/z (M+NH4) + 401 (100%). Part E: The product of Part D (148mg, 0.386 mmol)was coupled with methyl L-N^-p-toluylsulfonyl- diaminoproprionate according to the procedure in Example 43D. The crude material was chromatographed on silica gel (3% MeOH/CH2Cl2) to afford 230 mg clear glass containing minor impurities. !H NMR (CDCI3) δ 7.72 (d,2H), 7.33 (d,2H), 6.35 (m, IH) , 5.10 (m,lH), 4.61 (brd m, IH) , 4.45 (brd m, IH) , 3.97 ( brd m, IH) , 3.63-3.54 (s+m, 5H) , 3.48- 3.30 (m, 2H) , 3.15 (brd m,4H), 2.85 (s, 3H) , 2.75-2.5 (m, 4H), 2.45 (s, 3H) , 1.78 (brd m, 2H) , 1.46 (s,9H), 1.30 (m, 2H) ppm; Mass Spectrum (ESI) m/z (M+H)+ 638.5 (100%) Part F: The product of Part E (230 mg, 0.36 mmol) was subjected to hydrolysis and deprotection and purification by HPLC to afford 134 mg (58%) of a white powder, mp 69- 72°C; 1 HNMR (DMSO-d6) δ 8.35 ( brd m, 2H) , 8.10 (brd m, 2H) , 7.65 (d, J=6.96 Hz, 2H) , 7.35 (d, j=8.05 Hz, 2H) , 4.83 (m,lH), 4.36 (d,j=13.6 Hz, IH) , 4.12 (d,j=10 Hz, IH) , 4.0-3.5 (m,6H), 3.35 (m,lH), 3.14 (t,j=10.98 Hz, 1H),2.83 (m,lH), 2.59 (s, 3H) , 2.55 (m,lH), 2.36 (s, 3H) , 2.35 (m,lH), 2.0 (brd m,lH), 1.80-1.74 (brd m, 2H) , 1.18 (m, 2H) ppm; Mass Specturm (ESI) m/z (m+H)+ 524.4 (100%); IR (KBr) 3300-2800 brd, 1736,1632, 1202,1162 cm" 1 . Example 1774 N^-p-toluvlsulfonvl-N 3 --[3-(4-piperidinvlaminocarbonvl)- isoxazolin-5- (R.S)-vlacetvll-(S)-2.3- diaminoproprionatese535 Part A: The acid (from Part B described previously, 225mg, 0.98 mmol) was coupled with 1-tertbutyloxycarbonyl- 4-aminopiperidine (Obase, H; et al, J.Het. Chem. 1983, 20. 565) as described in Example 43D.A white foam was obtained in 78% yield. !R NMR (CDCI3) δ 6.50 (d, J=8.05 Hz, IH) , 5.13 (m, IH), 3.43 (dd, J= 10.62, 17.95 Hz, IH) , 3.04 (dd, J=7.69, 18.3 Hz, IH) , 2.87 (t, J=12.45 Hz, 2H) , 2.76 (dd, J= 6.22, 16.11 Hz, IH) , 2.57 (dd, J=6.95, 16.11 Hz, IH) , 1.94 (d, J=9.88 Hz, 2H) , 1.46 (s,18H), 1.41 (m, 2H)ppm; Mass Spectrum (NH3-CI) m/z (M+H) + 412.2 (69%), (M+NH4) + 429.3 (50%), (M+NH4-56)+ 373.2 (100%); IR (KBr) 3424,2866,1728,1692,1536,1426,1368,1238,1162 cm" 1 . Part B: The product of Part A (300 mg, 0.73 mmol) was deprotected with TFA and selectively reprotected with di-t-butyldicarbonate to afford 270 mg of a white foam. ^H NMR (CDCI3) δ 6.64 (d, J=8.05 Hz, IH) , 5.2 (m, IH) , 4.10- 3.95 (m, 3H) , 3.47 (dd, J=10.99, 17.96 Hz, IH) , 3.08 (dd, J=7.69, 17.95 Hz, IH) , 2.89 (t+dd, 3H) , 2.72 (dd, J= 6.95, 16.11 Hz, IH) , 1.94 (d, J=12.82 Hz, 2H) , 1.46 (s, 9H) , 1.46 (brd m, 2H)ppm; Mass Spectrum (NH3-CI) m/z (M+NH4) + 373 (100%) . Part C: The product of Part B (260 mg, 0.73 mmol) was coupled with methyl L-N^-p-toluylsulfonyl- diaminoproprionate according to the procedure in Example 43D. The crude foam was chromatographed on silica gel (2% MeOH/CH2Cl2) to afford 289 mg (65%) of a white foam. !H NMR (CDCI3) δ 7.71 (d, J=8.06 Hz, 2H) , 7.31 (d, J=8.42 Hz, 2H) , 6.65 (dd, J=6.59 Hz, IH) , 6.36 (t, J=5.86 Hz, IH) , 5.15 (m, IH) , 4.10-3.96 (m, 4H) , 3.63-3.56 (s+m, 5H) , 3.45-3.35 (m, IH) , 3.09 (m,lH), 2.85 (t, J=12.45 Hz, 2H) , 2.62 (m, 2H) , 2.43 (s, 3H) , 1.94 (d, J=12.82 Hz, 2H) , 1.45 (s+m, 9+2H)ppm; Mass Spectrum (ESI) m/z (M+H) + 610.3 (100%). Part D: The product of Part C (289 mg, 0.47 mmol) was subjected to hydrolysis and deprotection and purification as previously described to afford 224 mg (78%) white powder, mp 88-91°C; iHNMR (DMSO-de) δ 8.66-8.57 (d+m, j=7.69Hz, 2H) , 8.30 (brd m, IH) , 8.07 (m, 2H) , 7.64 (d,j=8.06 Hz, 2H) , 7.35 (d,j=8.06 Hz, 2H) , 4.94 (m,lH), 3.96 (m, IH) , 3.87 (q,j=6.95 Hz, IH) , 3.30-3.24 (m,4H), 3.08-2.89 (m,4H), 2.46 (m,lH), 2.37 (s,3H), 2.37 (m,lH), 1.87 (d,j=10.9 Hz,2H), 1.73 (q,j=10.6 Hz,2H) ppm; Mass Spectrum (ESI) m/z (M+H) + 496.3 (100%); IR (KBr) 3300-2800 brd, 1736,1666, 1544 1162 cm" 1 Example 1945 i\&-3-Methvlphenvlsulfonvl-.Ni-r3-r2-(piperidin-4- vl)ethvl!isoxazolin- (R . S)-vlacetvl)- (S)-2.3- dia inopropionic Acid TFΛ Salt Part A: Methvl (3-(2-i7-t-Butvloxvcarbonvlpiperidin-4- yl)ethyl)isoxazolin-5 (R. S)-ylacetate To a solution of Methyl Vinylacetate 352 g, 0.35 mol) in CH 2 CI 2 (175 mL) was added a 5% solution of sodium hypochlorite (210 mL, 0.15 mol). The mixture was stirred rapidly at room temperature and a solution of (3 -N- t- butyloxycarbonylpiperidin-4-yl)propanal oxime (Example 189, Part B, 17.60 g, 68.6 mmol) in CH 2 CI 2 (50 mL) was added over 15 h. The mixture was diluted with water and CH 2 CI 2 , the layers separated, and the aqueous washed with CH 2 CI 2 . The combined organic was dried (MgSθ4), concentrated in vacuo, and the oily residue purified using flash chromatography (10-50% EtOAc/hexanes step gradient), giving 10.35 g (42%) of the desired isoxazoline as a golden oil; Anal. Calcd for C 18 H 30 N 2 O 5 : C, 61.00; H, 8.53; N, 7.90. Found: C, 61.07; H, 8.50; N, 7.80. Part B: (3- (2 -N-t-Butvloxvcarbonvlpjperidin- - vl)ethvl) isoxazolin-5(J?.g)-vlacetic Acid To a solution of methyl ( 3 - ( 2-N- t- butyloxycarbonylpiperidin-4-yl)ethyl) isoxazolin-5 (R, S) - ylacetate (10.35 g, 29.20 mmol) in THF (100 mL) was added 0.5 M LiOH (80 mL, 40 mmol) . The resulting solution was stirred at room temperature overnight (18 h) and then concentrated in vacuo to one-half volume. The pH was adjusted to 4, and the resulting cloudy solution washed with CH 2 CI 2 (4 x 30 mL) . The combined organic was dried (MgSθ 4 ) , concentrated in vacuo, and placed under vacuum until constant weight was achieved, affording 9.74 g (98%) of the desired acid; Anal. Calcd for C 17 H2 8 N 2 O 5 : C, 59.98; H, 8.29; N, 8.23. Found: C, 60.19; H, 8.42; N, 7.87. p art C: t-gutyl fl 2 -- -Methylphenylsulfonyl-.a -r (3- (N-C butvloxvcarbonvl-2-piperidin-4-vl)ethvl)isoxazolin- (R . S) - vlacetvll - (S) -2.3-diaminopropionate To a solution of (3- (2-N- 1-butyloxycarbonylpiperidin- 4-yl)ethyl)isoxazolin-5 (R, S) -ylacetic acid (165 mg, 0.485 mmol) and t-butyl iV 2 -3-methylphenylsulfonyl- (S) -2 , 3 - diaminopropionate hydrochloride (170 mg, 0.485 mmol) in DMF (5 mL) was added Et 3 N (0.2 mL, 1.4 mmol) followed by TBTU (160 mg, 0.498 mmol). The resulting mixture was stirred for 4 h at room temperature, then was diluted with EtOAc (50 mL) . It was washed with water (4 x 20 mL) , sat. NaHC0 3 (30 mL), sat. NaCl and dried (MgSθ4) . Concentration in vacuo followed by placing the material under vacuum until constant weight was achieved afforded 271 mg (88%) of the desired amide; MS (ESI, e/z, relative intensity) : 637 (M + H) + , 20%, 537 (M + H - C4H 9 Cθ2) + , 51%. Part D: i£-3-Methylphenylsulfonyl-i -T (3- (2-pjperidin-4- vl)ethvl)isoxazolin-5 (R. S)-vlacetvll- ( S) -2,3- diaminopropionic Acid TFA Salt To a solution of t-butyl N 2 -3-methylphenylsulfonyl- N 3 -[ (3-(2V-fc-butyloxycarbonyl-2-piperidin-4- yl)ethyl)isoxazolin-5 (R, S)-ylacetyl]- (S) -2,3- diaminopropionate (261 mg, 0.410 mmol) in CH 2 CI 2 (2 mL) was added TFA (2 mL, 26 mmol) . After 2 h at room temperature, the solution was concentrated in vacuo and the residue triturated with ether (3 x 5 mL) . The resulting white powder was purified using reverse phase HPLC, giving 202 mg (83%) of the desired piperidine; MS (ESI, e/z, relative intensity): 481 (M + H)+, 100%. Example 2103 2-(3.5-dimethvlisoxazole-4-sulfonvl)-N--T3-(4- amidinophenvl)isoxazolin-5 (R . S)-vlacetvll-( s)-2.3- diaminopropionate Trifluoroacetate Salt Part A: Methvl M 2 --(3.5-Dimethvlisoxazole-4-sulfonvl) - i£r3-(4-N-t-butoxvcarbonvlamidinophenvl)isoxazolin-5(i?,S)- vlat.et-.vn- (S)-2.3-diaminopropionate Methyl N 2 -(3,5-dimethylisoxazole-4-sulfonyl)-iT 3 -Boc- (S) -2 , 3-diaminopropionate (1.40 mmole) was stirred with 4 M HCl/dioxane (10 mL, 40 mmol) at 25°C. After 2.5 h, the volatiles were removed in vacuo, and residual HCl/dioxane was removed by repeated addition of toluene and evaporation. To the residue was added 3 - ( 4-N-t- butoxycarbonylamidinophenyl)isoxazolin-5 (R, S)-ylacetic acid (510 mg, 1.47 mmol), TBTU (480 mg, 1.50 mmole) and DMF (15mL) . Triethylamine (0.830 mL, 603 mg, 5.97 mmole) was added and the reaction mixture was stirred at 25°C overnight. The mixture was diluted with water (70 mL) extracted with 3 X ethyl acetate. The combined organic extracts were washed with 2 X water, 5% pH 4 potassium hydrogen phthalate buffer (25 mL) , 5% aqueous sodium bicarbonate (25 mL) and brine. After drying over MgS04, removal of volatiles and purification by flash chromatography (ethyl acetate) provided 0.598 g of the desired product in 96% purity, as assessed by analytical HPLC (4.6 mm X 25 cm C18 reverse phase, 1 mL/min, 0.05% TFA/10-90% AcCN/water gradient over 20 min, product at 12.9 min); *H NMR (300 MHz, CDC1 3 ) 57.84 (m, 2H) , 7.63 ( , 2H), 6.52 (bm, IH) , 6.07 (bd, IH) , 5.11 (bm, IH) , 4.02 (bm, IH) , 3.66/3.67 (2s, 3H, diastereomers, methyl ester), 3.67-3.45 (m, 3H) , 3.15 (m, IH) , 2.60/2.61 (2s, 3H, diastereomers, isoxazole methyl), 2.76-2.55 (m, 2H) , 2.38/2.41 (2s, 3H, diastereomers, isoxazole methyl), 1.56 (s, 9H, t-Bu) ; MS (ESI): m/e 607.2 (M+H) + . Part B: i\£-(3.5-Dimethvlisoxazole-4-sulfonvl)-i^-f3-(4-JV- -butoxvcarbonvlamidinophenvl)isoxazolin-5 (R. S)-vlacetvll- (g)-2, -diaminopropionate To a solution of 200 mg (0.329 mmole) of methyl N 2 - (3 t 5.-dimethylisoxazole-4-sulfonyl) -N 3 [3- ( 4-N- t- butoxycarbonyl-amidinophenyl)isoxazolin-5 (R, S)-ylacetyl]- (S)-2,3-diamino-propionate in 15 mL of THF/MeOH/water 1:1:1 was added 138 mg (3.29 mmole) of LiOH. After 2 h, analytical HPLC (see conditions in Part A, product at 11.7 min) indicated the reaction was 97% complete. Removal of volatiles and purification by flash chromatography provided 0.164 g 91% pure (see HPLC conditions in Part A) of the desired product as a mixture of free acid and lithium salt (as indicated by 0.55% Li by elemental analysis); *H NMR (300 MHz, DMSO-dε) δ 8.02 (d, J = 8.0 Hz, 2H) , 7.96 (m, IH) , 7.75 (dd, J = 1.5, 8.4 Hz, 2H) , 5.02 (m, IH) , 3.58-3.08 (m, 5H) , 2.55 (s, 3H, isoxazole methyl), 2.60-2.37 (m, 2H) , 2.34 (s, 3H, isoxazole methyl), 1.45 (s, 9H, t-Bu) ; MS (ESI): m/e 593.3 (M+H) + , m/e 493.2 (M-Boc) + . Part C: N^- (3.5-dimethylisoxazole-4-sulfonyl) -N-2-- 3 - (4- amidinophenvl) isoxazolin-5 (R . S) -vlacetvll - ( S) -2 .3- diaminopropionate Trifluoroacetate Salt A solution of 137 mg (0.231 mmole) of N 2 - (3 , 5- dimethylisoxazole-4-sulfonyl) -W 3 [3- (4 -N-t-butoxycarbonyl- amidinophenyl) isoxazolin-5 (R, S) -ylacetyl] - (S) -2,3-diamino- propionate in 4 mL of CH 2 CI2 and 2 mL of TFA was stirred for 4 h, then diluted with 60 mL of ether. The precipitate was dried to give 0.103 g of the desired product as a white solid, which was determined to be 96% pure by analytical HPLC (see HPLC conditions in Part A) ; X H NMR (300 MHz, DMSO-d δ ) 59.79 (bs, IH) , 9.72 (bs, IH) , 9.29 (bs, 2H), 8.25 (bs, IH) , 8.16 (m, IH) , 7.87 (s, 4H) , 5.02 (bm, IH) , 3.78 (bs, IH) , 3.60-3.08 (m, 4H) , 2.54 (s, 3H, isoxazole methyl), 2.34 (s, 3H, isoxazole methyl), 2.62-2.34 (m, 2H) ; MS (ESI) : m/e 493.3 (M+H)+; HRMS (FAB): m/e calculated for C20H25 6O7S (M+H) + 493.150544; found 493.148681. Example 2103a M2- (3.5-dimethvlisoxazole-4-sulfonvl) - 3 -- \ 3 - (4- amidinophenvl) isoxazolin- ( R) -vlacetvll - (S) -2.3- diaminopropionate Trifluoroacetate Salt (Alternative Hvdrolvsis Procedure) Methyl N 2 - (3,5-dimethylisoxazole-4-sulfonyl) -N 3 - [3- (4- amidinopheny1)isoxazolin-5(J?) -ylacetyl] - (S) -2 , 3- diaminopropionate hydrochloride salt (Part B, replacing ammonium acetate with ammonium chloride, 1.3 g, 2.6 mmol) was stirred in 6N HCI (150 ml) at room temperature for 20 hours. Solvent was evaporated under reduced pressure to give the crude hydrochloride salt as a white solid (1.1 g, 87%) . Purification of 0.17 g crude product by preparative HPLC (Vydac C18 reverse phase column; 2 x 25 cm; 10 ml/min flow rate; 254 nM; gradient: from 100% H2O with 0.05% TFA to 20% H20 and 80% CH3CN with 0.05% TFA in 50 minutes) yielded 0.12 g (70.6%) of the title compound as a white powder. Chiral HPLC analysis (SFC, Chiralcel OD; 0.46 x 25 cm; 30°C; 2.0 ml/min flow rate; 0.1% TFA/22% MeOH/78% C02; 280 nM; 150 atm) showed >99% d.e. with respect to the (S, S)-diastereomer and >98% chemical purity. MS (ESI): m/e 493 (M+H) + . HRMS (FAB): m/e calculated for C20H24N6O7S (M+H) + 493.150649; Found 493.150544. Example 2103P iβ—(3.5-Dimethylisoxazole-4-sulfonyl)-i\ -T3-(4- amidinophenyl)isoxazolin-5 (R)-vlacetvll- (S) -2 . 3 - diaminopropionic Acid Methanesulfonate Salt Part A: Methyl ≠- ( , 5-pjιnethylisQ χ azQie-4-sulfpnyl) - diaminopropionate To a suspension of 3-(4-cyanophenyl)isoxazolin-5 (R) - ylacetic acid (252 mg, 0.725 mmol), methyl iV 2 -(3,5- dimethylisoxazole-4-sulfonyl- (S) -2,3-diaminopropionate hydrochloride (28.24 g, 70% purity, 63.0 mmol) in DMF (200 mL) was added TBTU (28.90 g, 90 mmol). The mixture was cooled to 0 °C and Et 3 N (31.4 mL, 225 mmol) was added dropwise. The resulting mixture was allowed to warm to room temperature overnight (18 h) , then was diluted with EtOAc (500 mL) . It was washed with water (4 x 200 mL) , sat. NaHC0 3 (100 mL) , sat. NaCl (100 mL) and dried (MgSθ 4 ) . Concentration in vacuo followed by placing the material under vacuum until constant weight was achieved afforded 25.06 g (81%) of the desired amide; X E NMR (300 MHz, CDCI 3 ) 58.77 (bs, IH) , 8.22 (t, J = 5.9 Hz, IH) , 5.02 (m, IH) , 3.98 (t, J = 7.0 Hz, IH) , 3.55 (dd, J = 17.2, 10.6 Hz, IH) , 3.48 (s, 3H) , 3.42 (m, IH) , 3.16 (m, 2H) , 2.54 (s, 3H, coincident with m, IH, DMSO-ds) , 2.37 (dd, J = 14.6, 7.0 Hz, IH) , 2.33 (s, 3H) . Part B: Methvl i\£- (3.5-Dimethvlisoxazole-4-sulfonvl) - diaminopropionate Acetate Salt Into a solution of methyl N 2 - (3, 5-dimethyl-isoxazole- 4-sulfonyl) -N 3 [3- (4- (cyanophenyl)isoxazolin-5 (R) - ylacetyl] - (S) -2 , 3-diaminopropionate (25.06 g, 51.17 mmol) in anhydrous MeOH (750 mL) at 0 °C was bubbled HCI gas for 3 hours. The resulting solution was then allowed to warm to room temperature overnight (18 h) , after which the solvent was evaporated in vacuo, to give an oil. The oily residue was triturated with ether (3 x 100 mL) and the resulting solid placed under vacuum until constant weight was achieved. The crude imidate was then dissolved in MeOH (1 L) and ammonium acetate (20.0 g, 259 mmol) added. The resulting mixture was stirred at room temperature for 18 h, then concentrated in vacuo. The residue was then crystallized from EtOH, giving 21.75 g of crude amidine. A portion of this material (8.5 g) was purified using flash chromatography (20% MeOH-EtOAc) to give 3.77 g (33%) of 97.6% pure amidine (analytical HPLC: 4.6 mm X 25 cm C18 reverse phase, 1 mL/min, 0.05% TFA/10-90% AcCN/water gradient over 20 min); *H NMR (300 MHz, DMSO-dε) 58.26 (bt, IH) , 7.86 (m, 4H) , 5.01 (m, IH) , 3.96 (t, J = 6.6 Hz, IH) , 3.56 (dd, J = 17.2, 10.6 Hz, IH) , 3.48 (s, 3H, coincident with m, IH) , 3.18 (m, 2H) , 2.53 (s, 3H, coincident with m, IH, DMSO-ds) , 2.54 (s, 3H) , 2.36 (dd, J = 14.6, 7.0 Hz, IH) , 2.32 (s, 3H) , 1.74 (s, 3H) ; MS (ESI): m/e 507.3 (M+H)+. Part C: JJ 2 -- (3.5-Dimethylisoxazole-4-sulfonyl) -l≠- 3 - (4- amidinophenvl) isoxazolin-5 (R) -vlacetvll - ( S) -2 .3- diaminopropionic Acid (Enzv atic Hvdrolvsis) To a solution of methyl N 2 - ( 3 , 5-dimethylisoxazole-4- sulfonyl-JJ 3 [3- (4-amidinophenyl) isoxazolin-5 (R) -ylacetyl] - ( S) -2 , 3-diaminopropionate HOAc salt (1.866 g, 3.29 mmol) in 0.4 J7 Hepes buffer (pH 7.1, 220 mL, 15 mmol) was added rabbit liver esterase (3.6 M crystalline suspension in ammonium sulfate, 2000 units, Sigma) . The resulting solution was incubated at 37 °C for 60 hours. Protein was removed from the reaction mixture by ultra filtration (Amicon YM-10 membrane) , and the filtrate was then concentrated in vacuo and lyophilized. Purification using a reverse phase silica column (5 x 9.5 cm in water; crude product loaded as an aqueous solution followed by elution with water (1200 mL) and by 500 mL each of 5, 10, 20 and 30% CH 3 CN-H 2 O. Fractions containing the desired product were pooled, acetonitrile was removed and the aqueous solution lyophilized to yield 1.5 g (93 %) of pure ~ zwitterion; 2 H NMR (300 MHz, DMSO-dβ) 57.93 (t, IH) , 7.76 (s, 4H) , 4.98 (m, IH) , 3.17-3.50 (m, 5H,coincident with water), 2.66 (dd, IH) , 2.56 (s, 3H) , 2.35 (s, 3H) , 2.36 (dd, IH) ; MS (ESI): m/e 493.3 (M+H) + . Part D: amidinophenvl)isoxazolin-5 (R)-vlacetvll- (S) -2.3- diaminopropionic Acid Methanesulfonic Acid Salt To a solution of the zwitterion (2.75 g, 5.43 mmol) in 50% CH3CN-H 2 O (135 mL) was added methanesulfonic acid (0.57 g, 5.97 mmol). The reaction mixture was stirred at room temperature for 1 h, resulting in a clear solution. Solvents were removed in vacuo and the residue placed under vacuum for several hours. The crude mesylate was dissolved in hot acetone and water until the solution was clear (120 mL total volume) . After hot filtration the solution was allowed to cool slowly and was then refrigerated for 24 h. The resulting white precipitate was filtered and dried under vacuum, affording 1.72 g (52%) of the title compound; λ E NMR (300 MHz, DMSO-dδ) 5 9.37 (bs, 2H), 9.03 (bs, 2H) , 8.57 (d, J = 9.5 Hz, IH) , 8.23 (t, J = 5.9 Hz, IH), 7.88 (s, 4H) , 5.03 (m, IH) , 3.91 (m, 2H) , 3.57 (dd, J = 17.2, 10.6 Hz, IH) , 3.44 (m, IH) , 3.21 (dd, J = 17.6, 7.7 Hz, IH) , 3.09 (m, IH) , 2.58 (dd, J = 14.6, 6.6 Hz, IH) , 2.54 (s, 3H) , 2.38 (dd, J = 14.6, 7.3 Hz, IH) , 2.33 (s, 3H, MsOH) ; MS (ESI) : m/e 493.2 (M+H) + ' " Anal. Calcd. for C 21 H 28 6O 1 0S 2 : C, 42.85; H, 4.79; N, 14.05; S, 10.89. Found: C, 42.45; H, 4.74; N, 14.05; S, 11.19. "• Example 2420 Methvl N^-n-butvloxvcarbonvl-N - Γ3- (4- pjperidinvlpropvl) isoxazolin-5- (R.S) -vlformvl ) - ( ) - .3- diaminopropionate TFA salt.sc568 HNMR (CDCI3) δ 7.38(1H, brd), 6.95 (IH,brd) , 5.65(1H, m) , 4.98(lH, m) , 4,42{1H, m),4.06(2H, ) , 3.76(3H, s) , 3.65(2H, m) , 3.48(2H, m) , 3.25(2H, m) , 2.95(2H, m) , 2.4( 2H, m) , 1.95(2H, brd), 1.6(5H, m) , 1.48(2H, m) , 1.35 (4H, m) , 0.94 (3H, m)ppm; ESI mass spectrum 441 (M+H) + free base Example 2421 isoxazolin-5- (R.S) -vlformvll - (S) -2.3-diaminopropionate TFA salt.sc570 1 ENMR (CDCI 3 ) δ: 7.8(lH, m) , 7.68(2H, m) , 7.3(3H, m) , 5.7(1H, m),4.92(lH, m) , 4.K1H, m) , 4.0(lH, m) , 3.7(2H, m) , 3.55(3H, s), 3.45(3H, m) , 2.9(2H, brd), 2.4(3H, s) , 2.38(2H, m) , 1.9(3H, m) , 1.65(2H, ) , 1.54(2H, m) , 1.35 (2H, m)ppm; ESI mass spectrum 495.3 (M+H) + free base. Example 2422 N2-p-toluenesulfonvl-Nl- \3 - (4-pjperidinvlpropvl) - isoxazolin-5- (R. ) -vlformvll - (S) -2.3-diaminopropionic acid TFA salt.sc571 ! HNMR (CD 3 OD)δ: 7.7(2H, m) , 7.32(2H, m) , 4.85(lH, m) , 4.K1H, m) , 3.75(1H, m) , 3.65(2H, m) , 3.32(3H, m) , 3.2(2H, m) , 2.9(2H, m) , 2.4(5H, m) , 1.95(2H, m) , 1.62(3H, m) , 1.35(4H, m) ,ppm; ESI mass spectrum 481.3 (M+H) + free base Example 2423 N--n-butyloxycarbonyl-N 3 -- \3-(4-piperidinylpropyl)- isoxazolin-5-(R.S)-vlformvll-(S)-2.3-diaminopropionic acid TFA salt. > ' i H MR (CD30D)δ: 4.92(1H, m) , 4.3(lH, m) , 4.05(2H, m) , 3.6(2H, m) , 3.38(3H, m) , 3.15(1H, m) , 2.95(2H, m) , 2.35(2H, m) , 1.95(2H, m) , 1.6(5H, m) , 1.35(6H, m) , 0.95(3H, m) ppm; ESI mass spectrum 427.3 (M+H) + free base.sc573 Example 2500 Methyl j y 3 --ppc-(ff)-2, -diaminopropionate Part A: Methyl JJ 2 --Cbz- -2,3-diaminopropionate HCI Salt To a solution of J7 2 -Cbz- -2,3-diaminopropionic acid (Bachem, 220 g, 0.923 mol) in MeOH (2 L) at 0 * C was added thionyl ' chloride (76 mL, 1.04 mol) over 20 min. The solution was warmed to room temperature overnight (18 h) and then concentrated to give a solid. The solid was crystallized from CHCl 3 -MeOH to give 172 g (64%) of the desired ester; *H NMR (DMSO-dβ) 58.38 (b, 3H) , 7.96 (d, IH) , 7.38 (m, 5H) , 5.05 (s, 2H) , 4.44 (m, IH) , 3.66 (s, 3H) , 3.14 (m, 2H) . Part B: Methyl JJ 2 --Cbz-J? 3 —Boc- -2.3-diaminopropionate To a solution of methyl JJ 2 -Cbz-(S)-2,3- diaminopropionate HCI salt (172 g, 0.596 mol) and di-tert- butyl dicarbonate (129.05 g, 0.591 mol) in CH 2 CI 2 (2 L) cooled in an ice bath was added a saturated solution of NaHC03 (1200 mL, 0.96 mol) and the solution was warmed to room temperature overnight (18 h) . The layers were separated and the aqueous washed with CH 2 CI 2 (2 x 500 mL) . The combined organic was washed with brine, dried (MgSθ 4 ), and concentrated. The resulting white solid was triturated with hexanes (3 x 500 mL) and dried under vacuum, giving 195.99 g (93%) of the desired material; H NMR (DMSO-dβ) : 5 7 . 60 ( d, IH) , 7 . 35 (m, 5H) , 6 . 88 ( t , IH) , 5 . 02 ( s , 2H) , 4 . 14 (m, IH) , 3 . 60 (s , 3H) , 3 .28 ( , 2H) , 1 . 37 ( s , 9H) . Part C: Methvl i -Boc- ( S) -2 .3-diaminopropionate To a solution of methyl JJ 2 -Cbz-J7 3 -Boc-(S)-2,3- diaminopropionate. (54.7 g, 0.155 mol) in EtOH (300 mL) was added 10% Pd/C (4.0 g) . The mixture was placed on a Parr apparatus and hydrogenated at 50 p.s.i. overnight (18 h) . The catalyst was filtered through Celite®, the filter cake washed with EtOH (3 x 50 mL) and the filtrate was concentrated in vacuo and placed under vacuum to give 32.63 g (96%) of the free base amine as a golden, viscous liquid; *H NMR (DMSO-dβ) : 58.20(s, IH) , 6.90 (t, IH) , 5.36 (b, 3H) , 3.61 9s, 3H) , 3.51 (t, IH) , 3.18 (t, 2H) , 1.38 (s, 9H) . Example 2502 Resolution of 3-(4-cvanophenvl)isoxazolin-5 (R.S)-vlacetic acid bv Crystallization 3-(4-Cyanophenyl)isoxazolin-5(S)-ylacetic acid (127 g, 0.55 moles) and (+)-cinchonidine (180.37 g, 0.55 mol) were added to acetone (2.0 L) and stirred at ambien temperature for at least 1.5 hrs. The resulting precipitate (169.21 g) was collected by filtration. The precipitate was dissolved in hot acetone (4.0 L) while stirring. After complete dissolution, the solution was allowed to stand overnight. The crystals formed were collected by filtration and recrystallized with acetone again to yield the 3-(4-cyanophenyl)isoxazolin-5(S) -ylacetic acid / (+)- cinchonidine salt in 33% overall yield and >99 % diastereomeric excess. The 3-(4-cyanophenyl)isoxazolin- 5(S)-ylacetic acid was liberated from its cinchonidine salt complex by suspending the salt in ethereal HCL (I N), filtering the solid after equilibration and evaporating the ether solution to provide the solid 3- (4- cyanophenyl)isoxazolin-5(S)-ylacetic acid. The R-isomer could be obtained from the mother liquor. Other chiral bases used include ephedrine, 2-phenylglycinol, 2-amino-3- methoxy-1-propanol, quinidine and pseudoephedrine. Example 2503 General Procedure for the Preparation of Compounds of the Formula (le) and (If) . Part A. Z-2,3-diaminopropionic acid (2.5 g, Fluka) was combined with Fmoc-N-Hydroxysuccinimide (1.1 eq. , 3.89 g) and NaHC03 (3 eq., 2.65 g) , in dioxane (24 ml) and H2θ (21 ml) . After stirring at room temperature overnight, the pH was adjusted with Na2C03 to pH 9. The solution was extracted three times with ethyl ether, then the aqueous layer was acidified with cone. HCI, with stirring. At pH 4-5, a solid precipitated out. This was filtered, rinsed with 1 N HCI, and dried. (93% yield) Part B. Wang resin (2.0 g, 1.16 mmole/g, Advanced Chem Tech) was added to triphenylphosphine (5 eq, 3.0 g) in 20 ml DMF. CBr4 (5 eq, 3.85 g) was then added and the solution was stirred at room temperature 3 hours. The resin was filtered and rinsed with DMF. Fmoc-Z-2,3- diaminopropionic acid (1.60 g, 1.5 equiv.) was dissolved in 20 ml DMF and the above resin was added, with 1.5 equiv. DIEA (0.60 ml) and 1.0 equiv. Csl (0.60 g) and stirred at room temperature overnight. The resin was filtered and rinsed with DMF and MeOH. Weight gain, IR, elemental analysis, and picric acid determination were used to establish the substitution level of the resin as approx. 0.8 mmole/g. Part C. The above derivatized resin (150 mg) was deprotected by mixing 10 min. with 20% piperidine/DMF. of The Fmoc-isoxazolin derivative (1.5 eq. , 0.18 mmole) was dissolved in 1.5 ml DMF and added to the resin with HBTU (1.5 eq, 68 mg) and DIEA (1.5 eq, 32 ul) . The tubes were mixed overnight, then drained, rinsed with DMF and MeOH, and the resin split into two portions. One portion was deprotected with 20% piperidine/DMF and then cleaved to produce the primary amine analogs. The other portion was deprotected with 20% piperidine/DMF and then coupled overnight with bis Boc-S-ethyl isothiourea (2 eq., 37 mg) and DEA (2 eq., 21 ul) in DMF. Part D. After rinsing, the compounds were cleaved from the resin by mixing with 1: 1 TFA:CH2Cl2 for two hours. The filtrate was rotovapped under reduced pressure to an oil, dissolved in 1: 1 acetonitrile:H20, and lyophilized. The crude material was analyzed by mass spec and HPLC. They were then purified by reverse phase HPLC (ACN:H2O:0.1 % TFA, C 18 column) . Using the above methods and variations thereof known in the art of organic synthesis, the additional examples in Tables 1-2, 2A-2D, 3-14 can be prepared. Ex. R2 R4 n R 14 n' No. Table 2 Example R 2 R8 MS Number (M+H) + Example R2 R8 MS Number (M+H) + Example R 2 R 8 Y MS Number (M+H) + R 8 MS (M+H) + Ph OEt -O OEt Ph OEt -ϋ OEt C0 2 Me OMe mp 160° Cθ2Me H 363 344 H n-butyl OMe 389 345 H n-butyl OEt 346 H isobutyl OH 347 H isobutyl OMe 389 348 H isobutyl OEt 403 349 H CH 2 SPh OH 350 H CH 2 SPh OMe 455 351 H CH 2 SPh OEt 352 H CH2θPh OH 353 H CH 2 OPh OMe 354 H CH 2 OPh OEt 355 H CH 2 SO 2 PI OH 356 H CH 2 S0 2 Ph OMe 357 H CH 2 S0 2 Ph OEt 358 H CH 2 NHS0 2 Ph OH 359 H CH 2 NHS0 2 Ph OMe 502 360 H CH 2 NHS0 2 Ph OEt 361 H CH 2 NHS0 2 n-Bu OH 362 H CH 2 NHS0 2 n-Bu OMe 482 363 H CH 2 NHS0 2 n-Bu OEt 364 H CH 2 COOH OH 377 365 H CH2C00Me OMe 405 Table A Example ?l- • < V ιl6 MS Number (M+H) + 275 4-amidinophenyl 276 4-amidinophenyl 277 4-amidinophenyl 278 4-amidinophenyl 278a 4-amidinophenyl 278b 4-amidinophenyl 279 4-amidinophenyl 280 4-amidinophenyl 290 4-amidinophenyl 291 4-amidinophenyl 292 4-amidinophenyl 293 4-amidinophenyl 294 4-amidinophenyl 295 4-amidinophenyl 296 -amidinophenyl 297 4-amidinophenyl 298 -amidinophenyl 299 4-amidinophenyl 300 4-amidinophenyl 301 4-amidinophenyl 302 4-amidinophenyl 303 4-amidinophenyl 304 4-amidinophenyl 305 4-amidinophenyl 306 4 -amidinophenyl 3-pyridylmethyl- OH carbonyl Example R^—V R 16 MS Number (M+H) + 307 4-amidinophenyl 308 4-amidinophenyl 309 4-amidinophenyl 310 4-amidinophenyl Example R 1 —V Number 332 4-amidinophenyl 333 4-amidinophenyl 334 4-amidinophenyl 335 4-amidinophenyl 336 4-amidinophenyl 337 4-amidinophenyl 374 440 4-(BOCamidino)phenyl 442 4-(BOCamidino)phenyl 443 4-amidinophenyl 444 4-amidinophenyl 445 4-amidinophenyl 445a 4-amidinophenyl 451 H " Λ_ 471 4-amidinophenyl 476 4-amidinophenyl 477 4-amidinophenyl Example R^-V R16 MS Number (M+H) + 478 4-amidinophenyl 2,4, 6-trimethyl- OMe 530 phenylsulfonyl 478a 4-amidinophenyl 2,4, 6-trimethyl- OH 516 phenylsulfonyl 479 4-amidinophenyl 2-chlorophenyl- OMe 522 sulfonyl 479a 4-amidinophenyl 2-chlorophenyl- OH 508 sulfonyl 480 4-amidinophenyl 2-trifluoromethyl- OMe - 556 phenylsulfony1 481 4-amidinophenyl 4-trifluoromethyl¬ OMe 556 phenylsulfonyl 482 4-amidinophenyl 2-fluoropheny1- OMe 506 sulfonyl 483 4-amidinophenyl 4-fluoropheny1- OMe 506 sulfonyl 484 4-amidinophenyl 4-methoxypheny1- OMe 518 sulfonyl 485 4-amidinophenyl 2,3,5, 6-tetramethyl- OMe 544 phenylsulfonyl 485a 4-amidinophenyl 2,3,5, 6-tetramethyl- OH 530 phenylsulfonyl 486 4-amidinophenyl 4-cyanopheny1- OMe 513 sulfonyl 487 4-amidinophenyl 4-ch1oropheny1- OMe 522 sulfonyl 488 4-amidinophenyl 4-ethylphenyl¬ OMe 516 sulfonyl 489 4-amidinophenyl 4-propylpheny1- OMe 530 sulfonyl 490 4-amidinophenyl n-propylsulfonyl 490a 4-amidinophenyl n-propylsulfonyl 491 -amidinophenyl 2-phenylethy1- sulfonyl 492 4 -amidinophenyl 492a 4 -amidinophenyl 493 4 -amidinophenyl 494 4 -amidinophenyl Example R^— V Number 495 4-amidinophenyl 496 4-amidinophenyl 497 4-amidinophenyl 498 4-amidinophenyl 499 4-amidinophenyl 500 4-amidinophenyl 501 4-amidinophenyl 502 4-amidinophenyl 503 4-amidinophenyl 504 4-amidinophenyl 505 4-amidinophenyl 506 4-amidinophenyl 507 4-amidinophenyl 508 4-amidinophenyl 509 4-amidinophenyl 510 4-amidinophenyl 511 4-amidinophenyl dimethylamino- OMe 455 sulfonyl 512 4-amidino-2-fluoro¬ 3-methylpheny1- OMe 520 phenyl sulfonyl 512A 4-amidino-2-fluoro¬ 3-methylphenylsulfonyl OH 506 phenyl Example R 1 -^ pl6 v MS Number (M+H) + 514 2-amidino-5-pyridyl 514A 2-amidino-5-pyridyl 516 3-amidino-6-pyridyl 516A 3-amidino-6-pyridyl 518 4-amidinophenyl 519 4-amidinophenyl 526 4-amidinophenyl 527 4-amidinophenyl 528 4-amidinophenyl 528a 4-amidinophenyl 529 4-amidinophenyl 530 4-amidinophenyl 531 4-amidinophenyl 532 4-amidinophenyl 533 4-amidinophenyl 534 4-amidinophenyl Example R^—V Number 535 4-amidinophenyl 536 4-amidinophenyl 537 4-amidinophenyl 538 4-amidinophenyl 539 4-amidinophenyl 540 4-amidinophenyl 540a 4-amidinophenyl 541 4-amidinophenyl 541a 4-amidinophenyl 542 4-amidinophenyl 543 4-amidinophenyl 544 4-amidinophenyl 545 4-amidinophenyl 546 4-amidinophenyl 547 4-amidinophenyl 548 4 -amidinophenyl 3-bromo-2- OMe 574 thienylsulfonyl 549 4 -amidinophenyl 5-bromo-2- OMe 574 thienylsulfonyl 550 4 -amidinophenyl 5-[l-methyl-5- OMe 642 trifluoromethyl-3- pyrazolyl]-2- thienylsulfonyl Example R 1 - V Number 551 4-amidinophenyl 552 4-amidinophenyl 553 4-amidinophenyl 554 4-amidinophenyl 555 4-amidinophenyl 556 4-amidinophenyl 557 4-amidinophenyl 558 4-amidinophenyl 559 4-amidinophenyl 560 4-amidinophenyl 561 4-amidinophenyl 562 4-amidinophenyl 4-N,N-dimethylamino-1- OH haphthylsulfonyl 563 4-amidinophenyl 2, l,3-benzoxadiazol-4- OMe ylsulfonyl 564 4-amidinophenyl 2,1,3-benzoxadiazol-4- OH ylsulfonyl 565 4-amidinophenyl 2,2,5,7,8-pentamethyl OMe 3,4-dihydro-2Hbenzo- pyran-6-ylsulfonyl Example R^—V D16 v MS Number (M+H) + 566 4-amidinophenyl 2,2,5,7,8-pentamethyl OH 3,4-dihydro-2Hbenzo- pyran-6-ylsulfonyl 567 4-N-methylamidino 3-methylphenylsulfonyl OMe phenyl 568 4-N-ethylamidino 3-methylphenylsulfonyl OMe 530 phenyl 569 4-N-n-propylamidino 3-methylphenylsulfonyl OMe phenyl 570 4-N-benzylamidino phenyl3-methylphenylsulfonyl OMe 571 4-N-n-butylamidino 3-methylphenylsulfonyl OMe 558 phenyl 572 4-N-methylamidino 3-methylphenylsulfonyl OH phenyl 573 4-N-ethylamidino 3-methylphenylsulfonyl OH 516 phenyl 574 4-N-n-propylamidino 3-methylphenylsulfonyl OH phenyl 575 4-N-benzylamidino 3-methylphenylsulfonyl OH phenyl 576 4-N-n-butylamidino 3-methylphenylsulfonyl OH 544 phenyl 577 4-N-methylamidino- n-butyloxycarbony1 OMe phenyl 578 4-N-ethylamidinophenyl n-butyloxycarbonyl OMe 579 4-N-npropylamidino- n-butyloxycarbonyl OMe phenyl 580 4-N-n-butylamidino- n-butyloxycarbonyl OMe 504 phenyl 581 4-N-benzylamidino- n-butyloxycarbonyl OMe phenyl Example R^—V >16 MS Number (M+H) + 582 4-N-methylamidino- n-butyloxycarbonyl OH phenyl 583 4-N-ethylamidino- n-butyloxycarbonyl OH phenyl 584 4-N-n-propylamidino- n-butyloxycarbonyl OH phenyl 585 4-N-n-butylamidino- n-butyloxycarbonyl OH phenyl 586 4-N-benzylamidino- n-butyloxycarbonyl OH phenyl 589 4-(acetoxyamidino)- n-butyloxycarbonyl OMe phenyl 590 4-(acetoxyamidino)- n-butyloxycarbonyl OH phenyl 591 4-(acetoxyamidino)- isobutyloxycarbonyl OMe phenyl 592 4-(acetoxyamidino)- isobutyloxycarbonyl OH phenyl 593 4-(acetoxyamidino)- cyclopropylethoxy- OMe phenyl carbonyl 594 4-(acetoxyamidino)- cyclopropylethoxy- OH phenyl carbonyl 595 4-(acetoxyamidino)- benzyloxycarbonyl OMe phenyl 596 4-(acetoxyamidino)- benzyloxycarbonyl OH phenyl 597 4-(acetoxyamidino)- 4-methylphenylsulfonyl OMe phenyl 598 4-(acetoxyamidino)- 4-methylphenylsulfonyl OH phenyl carbonyl 623 4-amidinophenylmethyl cyclopropylethoxy OH carbonyl 624 4-amidinophenylmethyl 4-methylphenylsulfonyl OMe 625 4-amidinophenylmethyl 4-methylphenylsulfonyl OH 488 626 4-amidinophenylmethyl 3-methylphenylsulfonyl OMe 627 4-amidinophenylmethyl 3-methylphenylsulfonyl OH Example R^—V Number 628 4-amidinophenylmethyl 629 4-amidinophenylmethyl 630 4-amidinophenyImethoxy 631 4-amidinophenyImethoxy 632 4-amidinophenyImethoxy 633 4-amidinophenyImethoxy 634 4-amidinophenyImethoxy 635 4-amidinophenyImethoxy 636 4-amidinophenyImethoxy 637 4-amidinophenyImethoxy 638 4-amidinophenyImethoxy 639 4-amidinophenyImethoxy 640 4-amidinophenyImethoxy 641 4-amidinophenyImethoxy 642 4-amidinophenyl 643 4-amidinophenyl 644 4-amidinophenyl 645 N-t-butyloxycarbonyl-4- amidinophenyl 646 N-t-butyloxycarbonyl-4- amidinophenyl ylsulfonyl 647 N-t-butyloxycarbony1- 3,5-dimethylisoxazol- OMe 607 4-amidinophenyl 4-ylsulfonyl TFA salt, 5(R) ,N 2 (S) isomer Tabl e 2B Example R^V >5a »16 MS Number (M+H) + 651 4-amidinophenyl methyl 496 652 4-amidinophenyl methyl 653 4-amidinophenyl methyl 654 4-amidinophenyl methyl 655 4-amidinophenyl methyl 656 4-amidinophenyl methyl 657 4-amidinophenyl methyl 658 4-amidinophenyl methyl 659 4-amidinophenyl methyl 660 4-amidinophenyl methyl Table 2C Example R^—V »16 Number 661 4-amidinophenyl benzyloxycarbonyl 662 4-amidinopheny1 benzyloxycarbonyl 663 4-amidinophenyl n-butyloxycarbonyl 664 4-amidinophenyl n-butyloxycarbonyl 665 4-amidinophenyl 3-methylphenylsulfonyl 666 4-amidinophenyl 3-methylphenylsulfonyl 667 4-amidinophenyl 4-methylphenylsulfon l 668 4-amidinophenyl 4-methylphenylsulfonyl methyl OH 669 4-amidinophenyl n-butylsulfonyl methyl OMe 670 4-amidinophenyl n-butylsulfonyl methyl OH Table 2D 722 4-amidinophenyl Example R^—V »16 MS Number (M+H) + 723 4-amidinophenyl 724 4-amidinophenyl 725 4-amidinophenyl 726 4-amidinophenyl 747 4-amidinophenyl 748 4-amidinophenyl 749 4-amidinophenyl 750 4-amidinophenyl 751 4-amidinophenyl 752 4-amidinophenyl 753 4-piperidinylethyl 754 4-(BOCamidino)phenyl 755 4-(BOCamidino)phenyl 756 4-amidinophenyl 757 4-amidinophenyl 758 4-piperidinylethy1 759 4-amidinophenyl 760 4-amidinophenyl 761 4-amidinophenyl 762 4-amidinophenyl 763 4-amidinophenyl 764 4-amidinophenyl 765 4-amidinophenyl Example R^—V Number 766 4-amidinophenyl 767 4-amidinophenyl 768 4-amidinophenyl 790 4-amidinophenyl 2-cyclopropylethoxy- OH carbonyl 791 4-amidinophenyl 2-cyclopentylethoxy- OMe carbonyl 792 4-amidinophenyl 2-cyclopentylethoxy- OH carbonyl 793 4-amidinophenyl n-propylsulfonyl OMe 794 4-amidinophenyl 2-methylpheny1- OMe sulfonyl 795 4-amidinophenyl 2-benzothienyl- OMe sulfonyl 796 4-amidinophenyl 2-benzothienyl- OMe sulfonyl 797 4-amidinophenyl 2,2,5,7,8-pentamethy1 OH 3,4-dihydro-2Hbenzo- pyran-6-ylsulfonyl 798 4-amidinophenyl 3-methylphenylsulfonyl OH 486 Table 2V. 822 4 -amidinophenyl Example -V »16 MS Number (M+H) + 823 4-amidinophenyl 824 4-amidinophenyl 825 4-amidinopheny1 826 4-amidinophenyl 847 4-amidinophenyl 848 4-amidinophenyl 849 4-amidinophenyl 850 4-amidinophenyl 851 4-amidinophenyl 852 4-amidinophenyl 853 4-piperidinylethyl 854 4-(BOCamidino)phenyl 855 4-(BOCamidino)pheny1 856 4-amidinophenyl 857 4-amidinophenyl 858 4-piperidinylethy1 859 4-amidinophenyl 860 4-amidinophenyl 861 4-amidinophenyl 862 4-amidinophenyl 863 4-amidinophenyl 864 4-amidinophenyl 865 4-amidinophenyl Example Ri-V Number 866 4-amidinophenyl 867 4-amidinophenyl 868 4-amidinophenyl Example R λ -v > 16 MS Number (M+H) + 890 4-amidinophenyl 2-cyclopropylethoxy- OH carbonyl 891 4-amidinophenyl 2-cyclopentylethoxy- OMe carbonyl 892 4-amidinophenyl 2-cyclopentylethoxy- OH carbonyl 893 4-amidinophenyl n-propylsulfonyl OMe 894 4-amidinophenyl 2-methylpheny1- OMe sulfonyl 895 4-amidinophenyl 2-benzothienyl- OMe sulfonyl 896 4-amidinophenyl 2-benzothienyl- OMe sulfonyl 897 4-amidinophenyl 2,2,5,7,8-pentamethyl OH 3,4-dihydro-2Hbenzo- pyran-6-ylsulfony1 Table 3 — 215 H H*N -C(=0)-N< 1 2 OEt Table 4 Example R 2 R la Z 1 Y Number 252 H -0 ~ CH 2 OH 253 H -NHCH 2 )2- CH 2 OH 254 H -NHCH 2 ) 3- CH 2 OH 255 H ~ 0 ~ 0 OH 256 H -NHCH 2 ) 2- 0 OH 257 H -NHCH 2 ) 3- O - OH 258 BOC " " CH 2 OH 268 H -NH(CH 2 ) 2 - CH 2 OEt 269 H -NH(CH 2 ) 3 - CH 2 OEt 270 H " O- 0 OEt 271 H -NH ( CH 2 ) 2" O OEt 272 H -NH ( CH 2 ) 3- O OEt Table 5 375 OH 373 CH 2 C(=0)Y OH —N NH YC(=0)CH 2 CH 2 C(=0)Y 418 OEt CH 2 C(=0)Y CH 2 C(=0)Y 432 -NHC(CH 3 ) 2 - OEt. CH 2 C(=0)Y 433 -N(CH 2 C 6 H 5 )- OEt Table 6 964 H H 2-fluoro- -phen-1,4- OH 493 phenyl- diyl sulfonyl 965 H H 4-CF 3 - -phen-1,4- OH 543 phenyl- diyl sulfonyl 966 H H 4-C1- -phen-1,4- OH 509 phenyl- diyl sulfonyl 967 H H f 1 -phen-1,4- OH 525 diyl ^ 968 3- H -phen-1,4- OH (CF 3 )- \ diyl benzyl 969 3- H tt V -phen-1,4- OH (CF 3 )- diyl benzyl r 970 3- CH3 3 -methyl - -phen-1,4- OH (CF 3 )- phenyl - diyl benzyl sulfonyl 971 3- CH3 -phen-1,4- OH (CF 3 )- *& diyl benzyl 972 nBu- H 3-methyl¬ -phen-i,4- Oh phenyl- diyl sulfonyl 973 nBu- H -phen-1,4- OH diyl 974 nBu- CH3 3-methyl- -phen-1,4- OH phenyl- diyl sulfonyl 975 nBu- CH3 -phen-1,4- OH diyl 976 CH3 CH3 ,4- OH 977 CH3 CH3 3-methyl- -phen-1,4- OH phenyl- diyl sulfonyl 978 H H 3-methyl¬ 5- OMe 490 phenyl- carboxamido sulfonyl pyrid-2-yl 979 H H 4-ethyl- -phen-1,4- OH 503 phenyl- diyl sulfonyl Table 7 980 4-amidinophenyl 981 4-amidinophenyl 982 4-amidinophenyl 983 4-amidinophenyl 984 4-amidinophenyl 985 4-amidinophenyl 986 -amidinophenyl 987 4-amidinophenyl 988 4-amidinophenyl 989 4-amidinophenyl 990 4-amidinophenyl 991 -amidinophenyl 992 4-amidinophenyl 993 4-amidinophenyl 994 4-amidinophenyl 995 4-amidinophenyl 996 4-amidinophenyl 474 997 4-amidinophenyl 998 4-amidinophenyl 999 4-amidinophenyl 1000 4-amidinophenyl 1001 4-amidinophenyl 1002 4-amidinophenyl Ex No. R^—V R 16 MS (M+H) + 1003 4-amidinophenyl 1004 4-amidinophenyl 1005 4-amidinophenyl 1006 4-amidinophenyl 1007 4-amidinophenyl 1008 4-amidinophenyl 1009 4-amidinophenyl 1010 4-amidinophenyl 1011 4-amidinophenyl 1012 4-amidinophenyl 1013 4-amidinophenyl 1014 4-amidinophenyl 1015 4-amidinophenyl 1016 4-amidinophenyl 1017 4-amidinopheny1 1018 4-amidinophenyl 1019 4-amidinophenyl 1020 4-amidinophenyl 1021 4-amidinophenyl 1022 4-amidinophenyl 1023 4-amidinophenyl 1024 -amidinophenyl 1025 4-amidinophenyl 1026 4-amidinophenyl 1027 4-amidinophenyl Ex No. R^—V 1029 4-amidinophenyl 1030 4-amidinophenyl 1031 4-amidinophenyl 1032 4-amidinophenyl 1033 4-amidinophenyl 1034 4-amidinophenyl 1035 4-piperidinylethy1 1036 4-(BOCamidino)phenyl 1037 4-(BOCamidino)phenyl 1038 4-amidinophenyl 1039 4-amidinophenyl 1040 4-amidinophenyl 1041 4-piperidinylethy1 1042 4-amidinophenyl 1043 4-amidinophenyl 1044 4-amidinophenyl 1045 4-amidinophenyl 1046 4-amidinophenyl 1047 4-amidinophenyl 1048 4-amidinophenyl Ex No. R^—V 1050 4-amidinophenyl 1051 4-amidinophenyl 1052 4-amidinophenyl 1053 4-amidinophenyl 1054 4-amidinophenyl 1055 4-amidinophenyl 1056 4-amidinophenyl 1057 4-amidinophenyl 1058 4-amidinophenyl 1059 4-amidinophenyl 1060 4-amidinophenyl 1061 4-amidinophenyl 1062 4-amidinophenyl 1063 4-amidinophenyl 1064 4-amidinophenyl 1065 4-amidinophenyl 1066 -amidinophenyl Ex No. R—V 1068 4-amidinophenyl 1069 4-amidinophenyl 1070 4-amidinophenyl 1071 -amidinophenyl 1072 4-amidinophenyl 1073 4-amidinophenyl 1074 4-amidinophenyl 1075 4-amidinophenyl 1076 4-amidinophenyl 1077 4-amidinophenyl 1078 4-amidinophenyl 1079 4-amidinophenyl 1080 4-amidinophenyl 1081 4-amidinophenyl 1082 -amidinophenyl 1083 4-amidinophenyl 1084 4-amidinophenyl 1085 4-amidino-2-fluoro¬ phenyl 1086 2-amidino-5-pyridyl Ex No. R^—V 1088 2-amidino-5-pyridyl 1089 3-amidino-6-pyridyl 1090 3-amidino-6-pyridyl 1091 4-amidinophenyl 1092 4-amidinophenyl 1093 4-amidinophenyl 1094 4-amidinophenyl 1095 4-amidinophenyl 1096 4-amidinophenyl 1097 4-amidinophenyl 1098 4-amidinophenyl 2-naphthy1carbony1 OMe 1099 4-amidinophenyl (2-chlorophenyl) OMe methoxycarbonyl 1100 4-amidinophenyl (2-chlorophenyl) OH methoxycarbonyl 1101 4-amidinophenyl (2-bromopheny1) OMe methoxycarbonyl 1102 4-amidinophenyl (2-bromopheny1) OH methoxycarbonyl 1103 4-amidinopheny1 n-hexyloxycarbonyl OMe 1104 4-amidinophenyl n-hexyloxycarbonyl OH 1105 4-amidinophenyl isobutyloxycarbonyl OMe 1106 4-amidinophenyl isobutyloxycarbonyl OH 1107 4-amidinophenyl 2-cyclopropylethoxy- OMe carbonyl 1108 4-amidinophenyl 2-cyclopropylethoxy- OH carbonyl Ex No. R^—V R 16 Y MS (M+H) + 1110 4-amidinophenyl 2-cyclopentylethoxy- OMe carbonyl 1111 4-amidinophenyl 2-cyclopentylethoxy- OH carbonyl 1112 4-amidinophenyl 4,4,4-trifluoro- OMe butyloxycarbonyl 1113 4-amidinophenyl 4,4,4-trifluoro- OH butyloxycarbony1 1114 4-amidinopheny1 n-propylsulfonyl OH 1115 4-amidinophenyl 2-methylpheny1- OMe sulfonyl 1116 4-amidinophenyl 4-chloro-2,5-dimethyl- OH 536 phenylsulfonyl 1117 4-amidinophenyl 2,3-dichlorophenyl- OMe sulfonyl 1118 4-amidinophenyl 2-bromopheny1- OMe sulfonyl 1119 4-amidinophenyl 1120 4-amidinophenyl 1121 4-amidinophenyl 1122 4-amidinophenyl 1123 4-amidinophenyl 1124 4-amidinophenyl 1125 4-amidinophenyl Ex No. R 1_V 1127 4-amidinophenyl 1128 4-amidinophenyl 1129 4-amidinophenyl 1130 4-amidinophenyl 1131 4-amidinophenyl 1132 4-amidinophenyl 1133 4-amidinophenyl 1134 4-amidinophenyl 1135 4-amidinophenyl 1136 4-amidinophenyl 1137 4-amidinophenyl 4-N,N-dimethylamino-1- OMe naphthylsulfonyl 1138 4-amidinophenyl 4-N,N-dimethylamino-1- OH haphthylsulfonyl 1139 4-amidinophenyl 2,1,3-benzoxadiazol-4- OMe ylsulfonyl 1140 4-amidinophenyl 2,1,3-benzoxadiazol-4- OH ylsulfonyl 1141 4-amidinophenyl 2,2,5,7,8-pentamethy1 OMe 3,4-dihydro-2Hbenzo- pyran-6-ylsulfonyl Ex No. R^—V R 16 MS (M+H) + 1143 4-amidinophenyl 2,2,5,7,8-pentamethy1 OH 3,4-dihydro-2Hbenzo- pyran-6-ylsulfonyl 1144 4-N-methylamidino 3-methylphenylsulfonyl OMe phenyl 1145 4-N-ethylamidino 3-methylphenylsulfonyl OMe phenyl 1146 4-N-n-propylamidino 3-methylphenylsulfonyl OMe phenyl 1147 4-N-benzylamidino pheny13-methylphenylsulfonyl OMe 1148 4-N-n-butylamidino 3-methylphenylsulfonyl OMe phenyl 1149 4-N-methylamidino 3-methylphenylsulfonyl OH phenyl 1150 4-N-ethylamidino 3-methylphenylsulfonyl OH phenyl 1151 4-N-n-propylamidino 3-methylphenylsulfonyl OH phenyl 1152 4-N-benzylamidino 3-methylphenylsulfonyl OH phenyl 1153 4-N-n-butylamidino 3-methylphenylsulfonyl OH phenyl 1154 4 -N-methy lamidino- n-butyloxycarbonyl OMe phenyl 1155 4 -N-ethy lamidinophenyl n-butyloxycarbonyl OMe 1156 4 -N-npropy lamidino¬ n-butyloxycarbonyl OMe phenyl 1157 4-N-n-butylamidino- n-butyloxycarbonyl OMe phenyl 1158 4-N-benzylamidino¬ n-butyloxycarbonyl OMe phenyl Ex No. R^—V R 16 MS (M+H) + 1160 4-N-methylamidino¬ n-butyloxycarbonyl OH phenyl 1161 4-N-ethylamidino¬ n-butyloxycarbony1 OH phenyl 1162 4-N-n-propylamidino¬ n-butyloxycarbonyl OH phenyl 1163 4-N-n-butylamidino¬ n-butyloxycarbonyl OH phenyl 1164 4-N-benzylamidino¬ n-butyloxycarbonyl OH phenyl 1165 4-(acetoxyamidino)- n-butyloxycarbonyl OMe phenyl 1166 4-(acetoxyamidino)- n-butyloxycarbonyl OH phenyl 1167 4-(acetoxyamidino)- isobutyloxycarbonyl OMe phenyl 1168 4-(acetoxyamidino)- isobutyloxycarbonyl OH phenyl 1169 4-(acetoxyamidino)- cyclopropylethoxy- OMe phenyl carbonyl 1170 4-(acetoxyamidino)- cyclopropylethoxy- OH phenyl carbonyl 1171 4-(acetoxyamidino)- benzyloxycarbonyl OMe phenyl 1172 4-(acetoxyamidino)- benzyloxycarbonyl OH phenyl 1293 guanidinopropyl 2-benzothiophene- OMe sulfonyl 1294 guanidinopropyl n-butyloxycarbonyl OH 1295 guanidinopropyl n-propyloxycarbonyl OH 1296 guanidinopropyl benzyloxycarbonyl OH 1297 guanidinopropyl n-butylsulfonyl OH 1298 guanidinopropyl 2-methylpheny1- OH sulfonyl 1299 guanidinopropyl 3-methylphenyl- OH sulfonyl 1300 guanidinopropyl 4-methylpheny1- OH sulfonyl 1301 guanidinopropyl 2-bromophenylsulfonyl OH 1302 guanidinopropyl 3-bromophenylsulfonyl OH 1303 guanidinopropyl 3,5-dimethyl- OH isoxazolylsulfonyl 1304 guanidinopropyl 2,4-dimethyl- OH thiazolylsulfonyl 1305 guanidinopropyl benzylsulfonyl OH 1306 guanidinopropyl styrylsulfonyl OH 1307 guanidinopropyl 2-benzothiophene- OH sulfonyl 1308 guanidinobutyl n-butyloxycarbonyl OH 1309 guanidinobutyl n-butylsulfonyl OH 1310 guanidinobutyl phenylsulfonyl OH 1311 guanidinobutyl 2-methylphenyl- OH sulfonyl 1312 guanidinobutyl 4-methylpheny1- OH sulfonyl 1313 guanidinobutyl 2-bromophenylsulfonyl OH 1314 guanidinobutyl 3,5-dimethyl- OH isoxazolylsulfonyl 1315 guanidinobutyl 2,4-dimethyl- OH thiazolylsulfonyl 1316 guanidinobutyl benzylsulfonyl OH 1317 guanidinobutyl styrylsulfonyl OH 1318 guanidinobutyl 3-fluorophenyl- OH sulfonyl 1319 guanidinobutyl n-butyloxycarbonyl OMe 1320 guanidinobutyl n-butylsulfonyl OMe 1321 guanidinobutyl benzyloxycarbonyl OH 449 1322 guanidinobutyl phenylsulfonyl OMe 1323 guanidinobutyl 2-methylpheny1- OMe sulfonyl 1324 guanidinobutyl 2-bromophenylsulfonyl OMe 1325 guanidinobutyl 3-bromophenylsulfonyl OMe 1326 guanidinobutyl 3,5-dimethyl- OMe isoxazolyl sufonyl 1327 guanidinobutyl benzylsulfonyl OMe 1328 guanidinobutyl n-butyloxycarbonyl OH 1329 guanidinobutyl isobutyloxycarbonyl OH 1330 guanidinobutyl n-propyloxycarbonyl OH 1331 guanidinobutyl phenylsulfonyl OH 1332 guanidinobutyl n-butylsulfonyl OH 1333 guanidinobutyl 2-methylpheny1- OH sulfonyl 1334 guanidinobutyl 3-methylpheny1- OH sulfonyl 1335 guanidinobutyl 4-methylpheny1- OH sulfonyl 1336 guanidinobutyl 2-bromophenylsulfonyl OH 1361 N- (4-piperidinyl- 3,5-dimethyl- OH methyl) -N-methyl - isoxazolylsulfonyl aminocarbonyl 1362 N- (4-piperidinyl- 3,5-dimethyl- OMe methyl ) -N-methyl- isoxazolylsulfonyl aminocarbonyl 1363 4-piperidinyl- n-butyloxycarbonyl OH aminocarbonyl 1364 4-piperidinyl- 4-methylphenyl- OH aminocarbonyl sulfonyl 1365 4-guanidinophenyl 2-methylpheny1- OH sulfonyl 1366 4-guanidinophenyl 2-methylpheny1- OMe sulfonyl 1367 4-guanidinophenyl 2-bromophenylsulfonyl OH 1368 4-guanidinophenyl 2-bromophenylsulfonyl OMe 1369 4-guanidinophenyl 3-methylphenyl- OH sulfonyl 1370 4-guanidinophenyl 3,5-dimethyl- OH isoxazolylsulfonyl 1371 4-guanidinophenyl 3,5-dimethyl- OMe isoxazolylsulfonyl 1372 4-guanidinophenyl 2,4-dimethyl- OH thiazolylsulfonyl 1373 4-guanidinophenyl 2,4-dimethyl- OMe thiazolylsulfonyl benzylsulfonyl OH benzylsulfonyl OMe styrylsulfonyl OH styrylsulfonyl OMe 2-benzothiophene- OH sulfonyl n-butyloxycarbonyl OH n-butyloxycarbonyl OMe n-propyloxycarbonyl OH 2-bromophenylsulfonyl OH 2-bromophenylsulfonyl OMe 2-methylpheny1- OH sulfonyl 1385 3-guanidinopheny1 4-methylphenyl- OH sulfonyl 1386 3-guanidinopheny1 4-methylphenyl- OMe sulfonyl 1387 3-guanidinopheny1 n-butylsulfonyl OH 1388 3-guanidinopheny1 n-butylsulfonyl OMe 1389 3-guanidinopheny1 styrylsulfonyl OH 1390 3-guanidinopheny1 benzyloxycarbonyl OH 1391 3-guanidinopheny1 benzyloxycarbonyl OMe 1392 4-amidinophenylmethyl 2-methylpheny1- OH sulfonyl 1393 4-amidinophenylmethyl 2-methylpheny1- OMe sulfonyl 1394 4-amidinophenylmethyl phenylsulfonyl OH 1395 4-amidinophenylmethyl phenylsulfonyl OMe 1396 4-amidinophenylmethyl 3,5-dimethyl- OH isoxazolylsulfonyl 1397 4-amidinophenylmethyl 3,5-dimethyl- OMe isoxazolylsulfonyl 1398 4-amidinophenylmethyl 2,4-dimethyl- OH thiazolylsulfonyl 1399 4-amidinophenylmethyl 2,4-dimethyl- OMe thiazolylsulfonyl 1400 4-amidinophenylmethyl p-toluylsulfonyl OH 1401 3-amidinophenylmethyl n-butyloxycarbonyl OH 1402 3-amidinophenylmethyl n-butyloxycarbonyl OMe 1403 3-amidinophenylmethyl phenylsulfonyl OH 1404 3-amidinophenylmethyl phenylsulfonyl OMe 1405 3-amidinophenylmethyl 2-bromophenylsulfonyl OH 1406 3-amidinophenylmethyl 2-bromophenylsulfonyl OMe 1407 3-amidinophenylmethyl 2-methylpheny1- OH sulfonyl 1408 3-amidinophenylmethyl 2-methylpheny1- OMe sulfonyl 1409 3-amidinophenylmethyl 4-methylpheny1- OH sulfonyl 1410 3-amidinophenylmethyl 4-methylphenyl- OMe sulfonyl 1411 3-amidinophenylmethyl styrylsulfonyl OH 1412 3-amidinophenylmethyl styrylsulfonyl OMe 1413 3-amidinophenylmethyl benzyloxycarbonyl OH 1414 3-amidinophenylmethyl benzyloxycarbonyl OMe 1415 3-amidinophenylmethyl 3,5-dimethyl- OH isoxazolylsulfonyl 1416 3-amidinophenylmethyl 3,5-dimethyl- OMe isoxazolylsulfonyl 1417 3-amidinophenylmethyl 2,4-dimethyl- OH thiazolylsulfonyl 1418 3-amidinophenylmethyl benzylsulfonyl OH 1419 4-pyridylethy1 n-benzyloxycarbonyl OMe 1420 4-pyridylethy1 n-benzyloxycarbonyl OH 1421 4-pyridylethy1 n-butyloxyoxycarbonyl OMe 1422 4-pyridylethy1 n-butyloxyoxycarbonyl OH 1423 4-pyridylethy1 2-methylphenylsulfonyl OH 1424 4-pyridylethy1 2-methylphenyl- OMe sulfonyl 1425 4-pyridylethy1 2-bromophenylsulfonyl OH 1426 4-pyridylethy1 2-bromophenylsulfonyl OMe 1427 4-pyridylethy1 3-methylphenyl- OH sulfonyl 1428 4-pyridylethy1 3,5-dimethyl- OH isoxazolylsulfonyl 1429 4-pyridylethy1 3,5-dimethyl- OMe isoxazolylsulfonyl 1430 4-pyridylethyl 2,4-dimethyl- OH thiazolylsulfonyl 1431 4-pyridylethy1 2,4-dimethyl- OMe thiazolylsulfonyl 1432 4-pyridylethy1 benzylsulfonyl OH 1433 4-pyridylethy1 styrylsulfonyl OH 1434 4-pyridylethy1 styrylsulfonyl OMe 1435 4-pyridylethy1 2-benzothiophene- OH sulfonyl 1436 3-pyridylethy1 n-benzyloxycarbonyl OMe 1437 3-pyridylethyl n-benzyloxycarbonyl OH 1438 3-pyridylethy1 n-butyloxyoxycarbonyl OMe 1439 3-pyridylethy1 n-butyloxyoxycarbonyl OH 1440 3-pyridylethy1 2-methylphenyl- OH sulfonyl 1441 3-pyridylethy1 2-methylphenyl- OMe sulfonyl 1442 3-pyridylethy1 2-bromophenylsulfonyl OH 1483 6-amino-3-pyridylethyl 1484 6-amino-3-pyridylethyl 1485 6-amino-3-pyridylethyl 1486 6-amino-3-pyridylethyl 1487 6-amino-3-pyridylethyl 1488 6-amino-4-pyridylethyl 1489 2-amidino-4- pyridylethyl 1490 2-amidino-4- pyridylethyl 1491 2-amidino-4- pyridylethyl 1492 2-amidino-4- pyridylethyl 1493 2-amidino-4- pyridylethyl 1494 2-amidino-4- pyridylethyl 1495 2-amidino-4- pyridylethyl 1496 2-amidino-4- pyridylethyl 1497 2-amidino-4- pyridylethyl 1498 2-amidino-4- pyridylethyl 1499 2-amidino-4- pyridylethyl 1500 2-amidino-4- pyridylethyl 1501 2-amidino-4- pyridylethyl 1502 2-amidino-4- pyridylethyl 1503 2-amidino-4- pyridylethyl 1504 2-amidino-4- pyridylethyl 1505 2-amidino-4- pyridylethyl 1506 2-amidino-4- pyridylethyl 1507 6-amidino-3- pyridylethyl 1508 6-amidino-3- pyridylethyl 1509 6-amidino-3- pyridylethyl 1510 6-amidino-3- pyridylethyl 1511 6-amidino-3- pyridylethyl 1512 6-amidino-3- pyridylethyl 1513 6-amidino-3- pyridylethyl 1514 6-amidino-3- pyridylethyl Table 8 1540 4-amidinophenyl 2 1 n-butyloxycarbonyl OH 446 1541 4-amidinophenyl 2 1 3-methylphenylsulfonyl OH 448 1542 4-amidinophenyl 1 1 benzyloxycarbonyl OMe 1543 4-amidinophenyl 1 1 (2-methylphenyl) - OH methoxycarbonyl 1544 4-amidinophenyl 1 1 (3-methylphenyl)- OH methoxycarbonyl 1545 4-amidinophenyl 1 2 i-butyloxycarbony1 OMe 1546 4-amidinophenyl 1 2 4-methylphenylsulfonyl OH 1547 4-amidinophenyl 1 2 2-methylphenylsulfonyl OH 1548 4-amidinophenyl 2 1 3,5-dimethylpyrazoyl- OH sulfonyl 1549 4-amidinophenyl 2 1 3,5-dimethylisoxazoyl- OH sulfonyl 1550 4-amidinophenyl 2 1 i-butylaminosulfonyl OH 1551 4-amidinophenyl 2 1 2-bromophenylsulfonyl OH 1552 4-piperidinylethyl 1 1 n-propyloxycarbonyl OMe 1553 4-piperidinylethy1 1 2 n-butylsulfonyl OH 1554 4-piperidinylethy1 1 2 (3-bromopheny1)- OH methylsulfonyl 1555 4-piperidinylethy1 2 1 (3-methylphenyl)- OMe methoxycarbonyl 1556 4-piperidinylethy1 2 1 2-phenylethoxycarbonyl OH 1557 4-(N-benzylamid¬ 1 1 n-butyloxycarbonyl OH ino)phenyl 1558 4-[N-(2-methylphenyl) 1 3-methylphenylsulfonyl OH methylamidino]phenyl 1559 4-[N-(2-bromopheny1)- 2 2-bromophenylsulfonyl OH methylamidino]phenyl 1560 4-(N-butylamidino) - 1 3, 5-dimethylpyrazoyl- OH phenyl sulfonyl 1561 4-[N-(2- 1 3-methylphenylsulfonyl OH methoxypheny1)- methylamidino]phenyl 1562 4-[N-(3-[trifluoro- 1 2,5-dimethylthiazolyl- OH methyl]phenyl)methyl- sulfonyl amidino]phenyl 1563 4-amidino-2-fluoro¬ 1 3-methylphenylsulfonyl OH phenyl 1564 4-amidino-2-fluoro¬ 2 i-butylaminosulfonyl phenyl 1565 4-amidino-2-fluoro¬ 3, 5-dimethylisoxazoyl- OH phenyl sulfonyl 1566 5-amidino-2-pyridyl 1 1 n-butyloxycarbonyl OMe 1567 5-amidino-2-pyridyl 1 2 2-methylphenylsulfonyl OH 1568 5-amidino-2-pyridyl 1 2 3-methylphenylsulfonyl OMe 1569 5-amidino-2-pyridyl 2 1 n-butylsulfonyl OH 1570 5-amidino-2-pyridyl 2 1 3, 5-dimethylisoxazoyl- OH sulfonyl 1571 2-amidino-5-pyridyl 1 1 2-bromophenylsulfonyl OH 1572 2-amidino-5-pyridyl 1 1 2-(trifluoromethyl)- OMe phenylsulfonyl 1573 2-amidino-5-pyridyl 1 2 n-propylaminocarbonyl OMe 1574 2-amidino-5-pyridyl 1 2 4-methylphenylsulfonyl OH 1575 2-amidino-5-pyridyl 2 1 2-fluorophenylsulfonyl OH Table 9 Example Ri-V »16 MS Number (M+H)+ 1585 4-piperidinylethyl n-butyloxycarbonyl OMe 441 1585A 4-piperidinylmethyl n-butyloxycarbonyl OH 427 1586 4-piperidinylethyl benzyloxycarbonyl OMe 1587 4-piperidinylethyl n-propyloxycarbonyl OMe 1588 4-piperidinylethyl isobutyloxycarbonyl OMe 1589 -piperidinylethyl 2-methylphenylsulfonyl OMe 1590 4-piperidinylethyl 3-methylphenylsulfonyl OMe — 1591 4-piperidinylethyl 4-methylphenylsulfonyl OMe 1592 4-piperidinylethyl 2-bromophenylsulfonyl OMe 1593 4-piperidinylethyl 3-bromophenylsulfonyl OMe 1594 4-piperidinylethyl 2-methoxyphenyl- OMe sulfonyl 1595 4-piperidinylethyl 3-methoxyphenyl- OMe sulfonyl 1596 4-piperidinylethyl 3-trifluoromethyl- OMe phenylsulfonyl 1597 4-piperidinylethy1 n-propylsulfonyl OMe 1598 4-piperidinylethy1 n-butylsulfonyl OMe 1599 4-piperidinylethyl isopropylsulfonyl OMe 1600 4-piperidinylethyl isobutylsulfonyl OMe 1601 4-piperidinylethy1 3,5-dimethyl- OMe isoxazolylsulfonyl 1602 4-piperidinylethyl 2,4-dimethyl- OMe thiazolylsulfonyl 1603 4-piperidinylpropyl n-butyloxycarbonyl OMe 455 1604 4-piperidinylpropyl n-propyloxycarbonyl OMe 1605 4-piperidinylpropyl benzyloxycarbonyl OMe 1606 4-piperidinylpropyl isobutyloxycarbonyl OMe 1607 4-piperidinylpropyl 2-methylphenyl- OMe sulfonyl 1608 4-piperidinylpropyl 3-methylphenyl- OMe sulfonyl 1609 4-piperidinylpropyl 4-methylphenyl- OMe 509 sulfonyl 1610 4-piperidinylpropyl 2-bromophenylsulfonyl OMe 1611 4-piperidinylpropyl n-butylsulfonyl OMe 1612 4-piperidinylpropyl isobutylsulfonyl OMe 1613 4-piperidinylpropyl 3,5-dimethyl- OMe isoxazolylsulfonyl 1614 4 -piperidinylpropyl 2,4-dimethyl- OMe thiazoylsulfonyl 1615 4-piperidinylethy1 n-butyloxycarbonyl OH 1616 4-piperidinylethyl n-propyloxycarbonyl OH 1617 4-piperidinylethy1 benyloxycarbonyl OH 1618 4-piperidinylethyl isobutyloxycarbonyl OH 1619 4-piperidinylethyl 2-methylphenyl- OH 481 sulfonyl 1767 N-(4-piperidinyl- 2-methylphenyl- OMe methy1)-N-methyl- sulfonyl aminocarbonyl 1768 N-(4-piperidinyl- 3-methylphenyl- OH methyl)-N-methyl- sulfonyl a inocarbonyl 1769 N-(4-piperidiny1- 4-methylphenyl- OH 524 methyl)-N-methyl- sulfonyl aminocarbonyl 1770 N-(4-piperidiny1- 3-methylpheny1- OMe methyl)-N-methyl- sulfonyl aminocarbonyl 1771 N-(4-piperidiny1- 3,5-dimethyl- OH methyl)-N-methyl- isoxazolylsulfonyl aminocarbonyl 1772 N-(4-piperidinyl- 3,5-dimethyl- OMe methyl)-N-methyl- isoxazolylsulfonyl aminocarbonyl 1801 3-guanidinopheny1 benzyloxycarbonyl OMe 1802 4-amidinophenylmethyl 2-methylphenyl- OH sulfonyl 1803 -amidinophenylmethyl 2-methylphenyl- OMe sulfonyl 1804 4-amidinophenylmethyl phenylsulfonyl OH 1805 4-amidinophenylmethyl phenylsulfonyl OMe 1806 4-amidinophenylmethyl 3,5-dimethyl- OH isoxazolylsulfonyl 1807 4-amidinophenylmethyl 3, 5-dimethyl- OMe isoxazolylsulfonyl 1808 4-amidinophenylmethyl 2,4-dimethyl- OH thiazolylsulfonyl 1809 4-amidinophenylmethyl 2,4-dimethyl- OMe thiazolylsulfonyl 1810 4-amidinophenylmethyl p-toluylsulfonyl OH Example R1_y R 16 Y MS Number (M+H)+ 1811 3-amidinophenylmethyl n-butyloxycarbonyl OH 1812 3-amidinophenylmethyl n-butyloxycarbonyl OMe 1813 3-amidinophenylmethyl phenylsulfonyl OH 1814 3-amidinophenylmethyl phenylsulfonyl OMe 1815 3-amidinophenylmethyl 2-bromophenylsulfonyl OH 1816 3-amidinophenylmethyl 2-bromophenylsulfonyl OMe 1817 3-amidinophenylmethyl 2-methylphenyl- OH sulfonyl 1818 3-amidinophenylmethyl 2-methylphenyl- OMe sulfonyl 1819 3-amidinophenylmethyl 4-methylphenyl- OH sulfonyl 1820 3-amidinophenylmethyl 4-methylphenyl- OMe sulfonyl 1821 3-amidinophenylmethyl styrylsulfonyl OH 1822 3-amidinophenylmethyl styrylsulfonyl OMe 1823 3-amidinophenylmethyl benzyloxycarbonyl OH 1824 3-amidinophenylmethyl benzyloxycarbonyl OMe 1825 3-amidinophenylmethyl 3,5-dimethyl- OH isoxazolylsulfonyl 1826 3-amidinophenylmethyl 3, 5-dimethyl- OMe isoxazolylsulfonyl 1827 3-amidinophenylmethyl 2,4-dimethyl- OH thiazolylsulfonyl 1828 3-amidinophenylmethyl benzylsulfonyl OH 1829 4-pyridylethyl n-benzyloxycarbonyl OMe 1830 4-pyridylethy1 n-benzyloxycarbonyl OH 1831 4-pyridylethy1 n-butyloxyoxycarbonyl OMe 1832 4-pyridylethyl n-butyloxyoxycarbonyl OH 1833 4-pyridylethy1 2-methylphenylsulfonyl OH 1834 4-pyridylethyl 2-methylphenyl- OMe sulfonyl 1835 4-pyridylethy1 2-bromophenylsulfonyl OH 1836 4-pyridylethy1 2-bromophenylsulfonyl OMe 1837 4-pyridylethy1 3-methylphenyl- OH sulfonyl 1838 4-pyridylethyl 3,5-dimethyl- OH isoxazolylsulfonyl 1839 4-pyridylethyl 3, 5-dimethyl- OMe isoxazolylsulfonyl 1840 4-pyridylethy1 2,4-dimethyl- OH thiazolylsulfonyl 1882 6-amino-3-pyridylethy1 1883 6-amino-3-pyridylethyl 1884 6-amino-3-pyridylethyl 1885 6-amino-3-pyridylethyl 1886 6-amino-3-pyridylethyl 1887 6-amino-3-pyridylethy1 1888 6-amino-3-pyridylethy1 1889 6-amino-3-pyridylethy1 1890 6-amino-3-pyridylethy1 Example R^—V Number 1891 6-amino-3-pyridylethyl 1892 6-amino-3-pyridylethyl 1893 6-amino-3-pyridylethyl 1894 6-amino-3-pyridylethyl 1895 6-amino-3-pyridylethyl 1896 6-amino-3-pyridylethyl 1897 6-amino-3-pyridylethy1 1898 6-amino-4-pyridylethyl 1899 2-amidino-4- pyridylethyl 1900 2-amidino-4- pyridylethy1 1901 2-amidino-4- pyridylethyl 1902 2-amidino-4- pyridylethyl 1903 2-amidino-4- pyridylethyl 1904 2-amidino-4- pyridylethyl 1905 2-amidino-4- pyridylethyl 1906 2-amidino-4- pyridylethyl 1907 2-amidino-4- pyridylethyl 1908 2-amidino-4- pyridylethy1 1909 2-amidino-4- pyridylethy1 1910 2-amidino-4- pyridylethy1 1911 2-amidino-4- pyridylethy1 1912 2-amidino-4- pyridylethyl 1913 2-amidino-4- pyridylethyl 1914 2-amidino-4- pyridylethyl 1915 2-amidino-4- pyridylethyl amidinophenyl HCI 1947 4-(N-2-methoxybenzyl)- 2-methylphenylsulfonyl OH 608.3 amidinophenyl TFA 2115 4-(N-ethyl)- 2-methylphenylsulfonyl OMe 530 amidinophenyl »TFA 2116 4-(N-ethyl)- 2-methylphenylsulfonyl OH 516 amidinophenyl »TFA 2117 4-amidinophenyl 4-methyl-2- OH 566 methylcarbonylamino-5- thiazolylsulfonyl »TFA 2118 4-amidinophenyl 5-phenylsulfonyl-2- OMe 634 thienylsulfonyl»TFA 2119 4-amidinophenyl 5-phenylsulfonyl-2- OMe 620 thienylsulfonyl»TFA 2120 N-t-butyloxycarbonyl-4- 5-phenylsulfonyl-2- OH 720 amidinophenyl thienylsulfonyl*TFA Table 10 Table 11 . 2225 H 2226 H 2227 H 2229 Br H OH CH 2 NHS0 2 - CH2NHCO2Λ-C3H7 OH CH2NHCO2Ω-C4H9 OH CH 2 NHCθ2n-C5Hn OH CH 2 NHC02CH 2 Ph OH CH2NHCθ2CH 2 CH 2 Ph OH CH2NHCO22-C4H9 OH CH 2 NHS02CH 2 Ph OH benzyl 2258 . , o- me thoxy- -CjCH OH benzyl Table 12 H 2280 guanidino benzyloxycarbonyl 2 2 449 2281 guanidino benzyloxycarbony1 1 2 435 2282 guanidino benzyloxycarbonyl 2283 guanidino benzyloxycarbonyl 2284 guanidino benzyloxycarbonyl 2285 guanidino benzyloxycarbonyl Table 13 Table 14 2420 4-piperidinylpropyl n-butyloxycarbonyl OMe 441 2421 4-piperidinylpropyl 4-methylphenylsulfonyl OMe 495 2422 4-piperidinylpropyl 4-methylphenylsulfonyl OH 481 2423 4-piperidinylpropyl n-butyloxycarbonyl OH 427 Utility The compounds of this invention possess antiplatelet efficacy, as evidenced by their activity in standard platelet aggregation assays or platelet fibrinogen binding assays, as described below. A compound is considered to be active in these assays if it has an IC50 value of less than about 1 mM. Platelet aggregation and fibrinogen binding assays which may be used to demonstrate the antiplatelet activity of the compounds of the invention are described below. Platelet Aσσreσation Assay: Venous blood was obtained from the arm of a healthy human donor who was drug-free and aspirin-free for at least two weeks prior to blood collection. Blood was collected into 10 mL citrated Vacutainer tubes. The blood was centrifuged for 15 minutes at 150 x g at room temperature, and platelet-rich plasma (PRP) was removed. The remaining blood was centrifuged for 15 minutes at 1500 x g at room temperature, and platelet-poor plasma (PPP) was removed. Samples were assayed on a aggregometer (PAP-4 Platelet Aggregation Profiler) , using PPP as the blank (100% transmittance) . 200 μL of PRP was added to each micro test tube, and transmittance was set to 0%. 20 μL of various agonists (ADP, collagen, arachidonate, epinephrine, thrombin) were added to each tube, and the aggregation profiles were plotted (% transmittance versus time) . The results are expressed as % inhibition of agonist-induced platelet aggregation. For the IC50 evaluation, the test compounds were added at various concentrations prior to the activation of the platelets. Ester prodrugs were preincubated (IO -3 M F.C.) with 100 IU/mL Porcine liver esterase (Sigma Chemical Co., St. Louis, MO, #E-3128) for 2 hours at 37 °C. Aliquots are then diluted in 0.1 M Tris, pH 7.4, to the desired concentrations. Aliquots of 20 μl of the esterase pretreated prodrugs are added to 200 μl of human platelet rich plasma. Samples were placed in platelet profiler (aggregometer) for 8 minutes at 37 °C, followed by the addition of 100 μM Adenosine Diphosphate, (Sigma Chemical Co., St. Louis, MO, #A-6521), to induce platelet aggregation. Platelet aggregation was allowed to proceed for 5 minutes. Percent inhibition is calculated using percent aggregation in the presence of the test compound divided by percent aggregation of control, times 100. This value is subtracted from 100, yielding percent inhibition. Calculation of IC 50 is performed on a Texas Instruments TI59 with an IC50 program. Purified GPIIb/IIIa-Fibrinoσen Binding ELISA The following reagents are used in the GPIIb/IIIa-fibrinogen binding ELISA: purified GPIIb/IIIa (148.8 μg/mL); biotinylated fibrinogen (- 1 mg/mL or 3000 nM) ; anti-biotin alkaline phosphatase conjugate (Sigma no. A7418) ; flat-bottom, high binding, 96-well plates (Costar Cat. no. 3590); phosphatase substrate (Sigma 104) (40 mg capsules); bovine serum albumin (BSA) (Sigma no. A3294); Alkaline Phosphatase buffer - 0.1 M glycine-HCl, 1 mM MgCl 2 »6H 2 0, 1 mM ZnCl 2 , pH 10.4; Binding buffer - 20 mM Tris-HCl, 150 mM NaCl, 1 mM CaCl 2 .2H 2 0, 0.02% NaN 3 , pH 7.0; Buffer A - 50 mM Tris-HCl, 100 mM NaCl, 2 mM CaCl 2 .2H 2 0, 0.02% NaN 3 , pH 7.4; Buffer A + 3.5% BSA (Blocking buffer); Buffer A + 0.1% BSA (Dilution buffer); 2N NaOH. The following method steps are used in the GPIIb/IIIa-fibrinogen binding ELISA: Coat plates with GPIIb/IIIa in Binding buffer (125 ng/100 μL/well) overnight at 4 °C (Leave first column uncoated for non-specific binding) . Cover and freeze plates at -70 °C until used. Thaw plate 1 hour at room temperature or overnight at 4 °C. Discard coating solution and wash once with 200 μL Binding buffer per well. Block plate 2 hours at room temperature on shaker with 200 μL Buffer A + 3.5% BSA (Blocking buffer) per well. Discard Blocking buffer and wash once with 200 μL Buffer A + 0.1% BSA (Dilution buffer) per well. Pipet 11 μL of test compound (10X the concentration to be tested in Dilution buffer) into duplicate wells. Pipet 11 μL Dilution buffer into non-specific and total binding wells. Add 100 μL Biotinylated fibrinogen (1/133 in Dilution buffer, final concentration = 20 nM) to each well. Incubate plates for 3 hours at room temperature on a plate shaker. Discard assay solution and wash twice with 300 μL Binding buffer per well. Add 100 μL Anti-biotin alkaline phosphatase conjugate (1/1500 in Dilution buffer) to each well. Incubate plates for 1 hour at room temperature on plate shaker. Discard conjugate and wash twice with 300 51 Binding buffer per well. Add 100 μL Phosphatase substrate (1.5 mg/mL in Alkaline phosphatase buffer) to each well. Incubate plate at room temperature on shaker until color develops. Stop color development by adding 25 μL 2N NaOH per well. Read plate at 405 nm. Blank against non-specific binding (NSB) well. % Inhibition is calculated as 100 - (Test Compound Abs/Total Abs)xl00. Platelet-Fibrinoσen Binding Assay: Binding of 125 ι- fibrinogen to platelets was performed as described by Bennett et al. (1983) Proc. Natl. Acad. Sci. USA 80: 2417- 2422, with some modifications as described below. Human PRP (h-PRP) was applied to a Sepharose column for the purification of platelet fractions. Aliquots of platelets (5 X IO 8 cells) along with 1 mM calcium chloride were added to removable 96 well plates prior to the activation of the human gel purified platelets (h-GPP) . Activation of the human gel purified platelets was achieved using ADP, collagen, arachidonate, epinephrine, and/or thrombin in the presence of the Iigand, 25 ι-fibrinogen. The 125 ι- fibrinogen bound to the activated platelets was separated from the free form by centrifugation and then counted on a gamma counter. For an IC50 evaluation, the test compounds were added at various concentrations prior to the activation of the platelets. The compounds of Formula I of the present invention may also possess thrombolytic efficacy, that is, they are capable of lysing (breaking up) already formed platelet- rich fibrin blood clots, and thus are useful in treating a thrombus formation, as evidenced by their activity in the tests described below. Preferred compounds of the present invention for use in thrombolysis include those compounds having an IC 50 value (that is, the molar concentration of the compound capable of achieving 50% clot lysis) of less than about 1 μM, more preferably an IC 50 value of less than about 0.1 μM. Thrombolytic Assay: Venous blood was obtained from the arm of a healthy human donor who was drug-free and aspirin free for at least two weeks prior to blood collection, and placed into 10 ml citrated Vacutainer tubes. The blood was centrifuged for 15 minutes at 1500 x g at room temperature, and platelet rich plasma (PRP) was removed. To the PRP was then added 1 x IO" 3 M of the agonist ADP, epinephrine, collagen, arachidonate, serotonin or thrombin, or a mixture thereof, and the PRP incubated for 30 minutes. The PRP was centrifuged for 12 minutes at 2500 x g at room temperature. The supernatant was then poured off, and the platelets remaining in the test tube were resuspended in platelet poor plasma (PPP) , which served as a plasminogen source. The suspension was then assayed on a Coulter Counter (Coulter Electronics, Inc., Hialeah, FL) , to determine the platelet count at the zero time point. After obtaining the zero time point, test compounds were added at various concentrations. Test samples were taken at various time points and the platelets were counted using the Coulter Counter. To determine the percent of lysis, the platelet count at a time point subsequent to the addition of the test compound was subtracted from the platelet count at the zero time point, and the resulting number divided by the platelet count at the zero time point. Multiplying this result by 100 yielded the percentage of clot lysis achieved by the test compound. For the IC 50 evaluation, the test compounds were added at various concentrations, and the percentage of lysis caused by the test compounds was calculated. The compounds of Formula I of the present invention are also useful for administration in combination with anti-coagulant agents such as warfarin or heparin, or antiplatelet agents such as aspirin, piroxicam or ticlopidine, or thrombin inhibitors such as boropeptides, hirudin or argatroban, or thrombolytic agents such as tissue plasminogen activator, anistreplase, urokinase or streptokinase, or combinations thereof. The compounds of Formula I of the present invention may also be useful as antagonists of other integrins such as for example, the α v /β 3 or vitronectin receptor, 0. 4 /βι or « 5 /βι and as such may also have utility in the treatment and diagnosis of osteoporosis, cancer metastasis, diabetic retinopathy, rheumatoid arthritis, inflammation, and autoimmune disorders. The compounds of Formula I of the present invention may be useful for the treatment or prevention of other diseases which involve cell adhesion processes, including, but not limited to, infanimation, bone degradation, rheumatoid arthritis, asthma, allergies, adult respiratory distress syndrome, graft versus host disease, organ transplantation, septic shock, psoriasis, eczema, contact dermatitis, osteoporosis, osteoarthritis, atherosclerosis, metastasis, wound healing, diabetic retinopathy, inflammatory bowel disease and other autoimmune diseases. Table A below sets forth the antiplatelet activity of representative compounds of the present invention. The indicated compounds were tested for their ability to inhibit platelet aggregation (using platelet rich plasma (PRP) ) . The IC 50 value (the concentration of antagonist which inhibits platelet aggregation by 50% relative to a control lacking the antagonist) is shown. In Table 5 the IC 50 values are expressed as: +++ = IC50 of <10 μM; ++ = IC50 of 10-50 μM; + = IC50 of 50-100 μM (μM = micromolar) . Table A Example Number plate et Platelet Aggregation Assay Aggregation Assay IC. 50 (without iC. 50 (with esterase) ++ + ++ + ++ + ++ + + + + ++ + + + + ++ + 275 +++ 276 +++ 278 +++ 290 +++ 300 +++ 312 +++ 314A (2S)t +++ 314B (2S)tt +++ 323 +++ 324 +++ 326 +++ 327 (2S) +++ 328 (2S) +++ 338 (3S) + +++ 339 (3S) +++ 340 (3S) + ++ 341 (3S) +++ 342 (2S) +++ 344 (3R) +++ 345 +++ 347 (3R)tt +++ 348 (3R) +++ 350 +++ 359 +++ 362 +++ 365 +++ 368 +++ 373 ++ 371A +++ 371B +++ 374 (2S) + +++ 375* +++ 377 +++ 394 +++ 394Att +++ 400 +++ 413* +++ 415 +++ 435 +++ 436 +++ 437 +++ 438 +++ 439 +++ 440 +++ 441 +++ 442 +++ 443 (2S) +++ 444 (2S) +++ 445 (2S) +++ 446 +++ 449A +++ 449B +++ 450 +++ 451 +++ 452 +++ 453 +++ 454 +++ 455 +++ 456 ++ 457 +++ 458A +++ 458B +++ 460A +++ 460B +++ 462 +++ 463 +++ 464 +++ 465 +++ 466 +++ 467 +++ 468 +++ 469 +++ 470 +++ 471 +++ 472 +++ 473 +++ 473A (2S) t +++ 473B (2S) tt +++ 474 +++ 475 +++ 476 +++ 477 +++ 478 +++ 479 +++ 480 +++ 481 +++ 482 +++ 483 +++ 484 +++ 485 +++ 486 +++ 487 +++ 488 +++ 489 +++ 490 +++ 491 +++ 492 +++ 493 +++ 494 +++ 495 +++ 496 +++ 504 +++ 505 +++ 506 +++ 507 +++ 508 +++ 509 +++ 510 +++ 511 +++ 512 +++ 513 +++ on on oπ ui ui oπ ui oπ ui on *> oo oo oo oo oo oo oo oo o vo oo -J cn ui ιt* oo to oo I + + + + + + + to + + + + + + + vo + + + + + + + o + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 552 +++ 553 +++ 554 +++ 555 +++ 556 +++ (2S)tt +++ 588 +++ 602 +++ 611 +++ 612 +++ 613 +++ 616 +++ 642 +++ 643 +++ 644 +++ 651 +++ 727 - +++ 729 +++ 798 +++ 829 +++ 1284 ÷++ 1321 +++ 1525 +++ 1694 +++ 1731 +++ 2104 +++ 2109 +++ 2110 +++ 2111 ÷++ 2112 +++ 2113 +++ 2114 +++ 2115 +++ 2116 +++ 2117 +++ 2113 +++ 2119 +++ 2120 +++ 2280 ÷++ 2281 +++ 2400 +++ 2401 +++ 2402 +++ 2403 +++ 2404 +++ 2405 +++ 2406 +++ * Single diastereomer, racemic t S isomer at C5 of isoxazoline ring tt R isomer at C5 of isoxazoline ring The compounds of the present invention may be useful for the treatment or prevention of other diseases which involve cell adhesion processes, including, but not limited' to, inflammation, bone degradation, thrombosis, rheumatoid arthritis, asthma, allergies, adult respiratory distress syndrome, grafc versus host disease, organ transplantation, septic shock, psoriasis, eczema, contact dermatitis, osteoarthritis, atherosclerosis, metastasis, wound healing, diabetic retinopathy, inflammatory bowel disease and other angiogenic disorders. The compounds of the formulae (le) and (If) possess selectivity as antagonists of integrins such as the ot β ? vitronectin receptor. (if) The integrin antagonist activity of the compounds of the present invention is demonstrated using assays -which measure the binding of a specific integrin to a native Iigand, for example, using the ELISA assay described below for the binding of vitronectin to the α v /β 3 receptor. The compounds provided by this invention are also useful as standards and reagents in determining the. ability of a potential pharmaceutical to inhibit integrin-Iigand binding. These would be provided in commercial kits comprising a compound of this invention. The α v /β 3 receptor was isolated from human piacental extracts prepared using octylglucoside. The extracts were passed over an affinity column composed of anti-α /β 3 monoclonal antibody (LM60 ) to Affigel. The column was subsequently washed extensively at pH 7 and pH 4.5 followed by elution at pK 3. The resulting sample was concentrated by wheat germ agglutinin chromatography to provide gave two bands on SDS gel which were confirmed as α v /β3 by western blotting. Affinity purified protein was diluted at different levels and plated to 96 well plates. ΞLISA was performed using fixed concentration of biotinylated vitronectin (approximately 80 nM/well) . This receptor preparation contains the α v /β3 with no detectable levels of α v /β? according to the gel (α v /β 3 ) and according to effects of blocking antibodies for the α v /β3 or α v /βs in the ELISA. A εubmaximal concentration of biotinylated vitronectin was selected based on cone, response curve with fixed receptor cone, and variable concentrations of biotinylated vitronectin. gyfe.-Vi rpnec-i Binding Assay, The purified receptor is diluted with coating buffer (20 mM Tris HCI, 150 mM NaCl, 2.0 mM CaC.l 2 , 1.0 mM MgCl 2 '6H 2 θ, 1.0 mM MnCl 2 « 4H^O) and coated (100 μl/well) on Costar (3590) high capacity binding plates overnight at 4°C. The coating solution is discarded and the plates washed once with blocking/binding buffer (B/B buffer, 50 mM Tris HCI, 100 mM NaCl, 2.0 mM CaC.. 2 ,1.0 mM M Cl2*6H 2 θ,1.0 mM MnCI÷j-4H O) . Receptor is then blocked (200 μl/well) with 3.5% BSA in B/B buffer for 2 hours at room temperature. After washing once with 1.0% BSA in B/B buffer, biotinylated vitronectin (100 μl) and either inhibitor (11 μl) or B/B buffer w/1.0% BSA (11 μl)is added to each well. The plates are incubated 2 hours at room temperature. The plates are washed twice with B/B buffer and incubated 1 hour at room temperature with anti-biotin alkaline phosphatase (100 μl/well) in B/B buffer containing 1.0% BSA. The plates are washed twice with B/B buffer and alkaline phosphatase substrate (100 μl; is added. Color is developed at room temperature. Color development is stopped by addition of 2N NaOH (25 μl well) and absorbance is read at 405 nm. The IC50 is the concentration of test substance needed to block 50% of the vitronectin binding to the receptor. ϊnteg i Cell-Based Ad esion Ass ys In the adhesion assays, a 96 well plate was coated with the Iigand (i.e., fibrinogen) and incubated overnight at 4° C. The following day, the cells were harvested, washed and loaded with a fluorescent dye. Compounds and cells were added together and then were immediately added to the coated plate. After incubation, loose ceils are removed from the plate, and the plate (with adherent cells) is counted on a fiuorometer. The ability of test compounds to inhibit cell adhesion by 50% is given by the IC 50 value and represents a measure of potency of inhibition of integrin mediated binding. Compounds were tested for their ability to block cell adhesion using assays specific for α v /β3, v /βs and αs/βi integrin interactions. Dosaσe and Formulation The compounds of the present invention can be administered in such oral dosage forms as tablets, capsules (each of which includes sustained release or timed release formulations) , pills, powders, granules, elixirs, tinctures, suspensions, syrups, and emulsions. Likewise, they may also be administered in intravenous (bolus or infusion) , intraperitoneal, subcutaneous, or intramuscular form, all using dosage forms well known to those of ordinary skill in the pharmaceutical arts. An effective but non-toxic amount of the compound desired can be employed as an anti-aggregation agent. Finally, the compounds of the invention may also be administered intranasali . The compounds of this invention can be administered by any means that produces contact of the active agent with the agent's site of action, glycoprotein Ilb/IIIa (GPIIb/IIIa), in the body of a mammal. They can be administered by any conventional means available for use in conjunction with pharmaceuticals, either as individual therapeutic agents or in a combination of therapeutic agents, such as a second antiplatelet agent such as aspirin or ticlopidine which are agonist-specific. They can be administered alone, but generally administered with a pharmaceutical carrier selected on the basis of the chosen route of administration and standard pharmaceutical practice. The dosage regimen for the compounds of the present invention will, of course, vary depending upon known factors, such as the pharmacodynamic characteristics of the particular agent and its mode and route of administration; the species, age, sex, health, medical condition, and weight of the recipient; the nature and extent of the symptoms; the kind of concurrent treatment; the frequency of treatment; the route of administration, the renal and hepatic function of the patient,and the effect desired. An ordinarily skilled physician or veterinarian can readily determine and prescribe the effective amount of the drug required to prevent, counter, or arrest the progress of the condition. By way of general guidance, the daily oral dosage of each active ingredient, when used for the indicated effects, will range between about 0.001 to 1000 mg/kg of body weight, preferably between about 0.01 to 100 mg/kg of body weight per day, and most preferably between about 1.0 to 20 mg/kg/day. Intravenously, the most preferred doses will range from about 1 to about 10 mg/kg/minute during a constant rate infusion. Advantageously, compounds of the present invention may be administered in a single daily dose, or the total daily dosage may be administered in divided doses of two, three, or four times daily. The compounds for the present invention can be administered in intranasal form via topical use of suitable intranasal vehicles, or via transdermal routes, using those forms of transdermal skin patches wall known to those of ordinary skill in that art. To be administered in the form of a transdermal delivery system, the dosage administration will, of course, be continuous rather than intermittant throughout the dosage regimen. It has unexpectedly been found that compounds of the present invention can be delivered by the nasal route of administration. The delivery of Example 327 (and it's free acid Example 300) through the nasal route provided very high bioactivity (inhibition of platelet aggregation) that was similar to that observed after administering the same dose intravenously. Also dog to dog variability was very small. For example, nasal and i.v. administration of 0.025 mg/kg gave similar profiles of platelet aggregation inhibition, however comparable effect after oral administra ion was only seen at doses equal or greater than 0.4 mg/kg. Therefore, the advantages of delivering Example 327 nasally are to enhance bioavailability and reduce variability. The latter is very important due to the steep dose response of these types of compounds. The active ingredient can be administered intranasally to a mammal at a dosage range of about 0.01 to 0.5 mg/kg while the preferred dosage range is about 0.01-0.1 mg/kg. Compositions of the active ingredients can be administered intranasally by preparing a suitable formulation of the active ingredient by procedures well known to those skilled in the art. Preferably the formulations are prepared with suitable nontoxic pharmaceutically acceptable ingredients. These ingredients are known to those skilled in the preparation of nasal dosage fox * ms and some of these can be found in Remington's Pharmaceutical Sciences. Mack Publishing Company, 17th edition, 1985, a standard reference in the field. The choice of suitable carriers is highly dependent upon the exact nature of the nasal dosage form desired, e.g., solutions, suspensions, ointments, or gels. Nasal dosage forms generally contain large amounts of water in addition to the active ingredien . Minor amounts of other ingredients such as pH adjusters, einulsifiers or dispersing agents, preservatives, surfactants, jelling agents, or buffering and other stabilizing and solubilizing agents may also be present. Preferably, the nasal dosage form should be isotonic with nasal secretions. An example of a nasal solution composition of this invention includes: In this example the active drug can be in one vial and the rest of the formulation can be in another vial. The drug can be reconstituted when needed. The formulation of this invention may be varied to include: (1) other acids and bases to adjust the pH; (2) other tonicity imparting agents such as glycerin and dextrose; (3) other antimicrobial preservatives such as other parahydroxy benzoic acid esters, sorbate, benzoate, propionate, chiorbutanol, phenylethyl alcohol, and mercurials; (4) other viscosity imparting agents such as sodium carboxy-methylcellulose microcrystalline cellulose, polyvinyl-pyrrolidone, polyvinyl alcohol and other gums; (5) suitable absorption enhancers; (6) stabilizing agents such as antioxidants, like bisulfite and ascorbate, metal chelating agents such as sodium edetate and drug solubility enhancers such as polyethylene glycols. The above formulation can be administered as drops, sprays, aerosols or by any other intranasal dosage form. Optionally, the delivery system can be a unit dose delivery system. The volume of solution or suspension delivered per dose can be anywhere from 5 to 400 μL, and preferably between 50 and 150 μL. Delivery systems for these various dosage forms can be dropper bottles, plastic squeeze units, atomizers, nebulizers or pharmaceutical aerosols in either unit dose or multiple dose packages. In the methods of the present invention, the compounds herein described in detail can form the active ingredient, and are typically administered in admixture with suitable pharmaceutical diluents, excipients, or carriers (collectively referred to herein as carrier materials) suitably selected with respect to the intended form of administration, that is, oral tablets, capsules, elixirs, syrups and the like, and consistent with conventional pharmaceutical practices. For instance, for oral administration in the form of a tablet or capsule, the active drug component can be combined with an oral, non-toxic, pharmaceutically acceptable, inert carrier such as lactose, starch, sucrose, glucose, methyl callulose, magnesium stearate, dicalcium phosphate, calcium sulfate, mannitol, sorbitol and the like; for oral administration in liquid form, the oral drug components can be combined with any oral, non¬ toxic, pharmaceutically acceptable inert carrier such as ethanol, glycerol, water, and the like. Moreover, when desired or necessary, suitable binders, lubricants, disintegrating agents, and coloring agents can also be incorporated into the mixture. Suitable binders include starch, gelatin, natural sugars such as glucose or beta- lactose, corn sweeteners, natural and synthetic gums such as acacia, tragacanth, or sodium alginate, carboxymethylcellulose, polyethylene glycol, waxes, ana the like. Lubricants used in these dosage forms include sodium oleate, sodium stearate, magnesium stearate, sodium benzoate, sodium acetate, sodium chloride, and the like. Disintegrators include, without limitation, starch, methyl cellulose, agar, bentonite, xanthan gum, and the like. The compounds of the present invention can also be administered in the form of liposome delivery systems, such as small unilamellar vesicles, large unilamallar vesicles, and multilamellar vesicles. Liposomes can be formed from a variety of phospholipids, such as cholesterol, stearylamine, or phosphatidylcholines. Compounds of the present invention may also be coupled with soluble polymers as targetable drug carriers. Such polymers can include polyvinylpyrrolidone, pyran copolymer, polyhydroxypropylmethacrylamide-phenol, polyhydroxyethylaspartamidephenol, or polyethyleneoxide- polylysine substituted with palmitoyl residues. Furthermore, the compounds of the present invention may be coupled to a class of biodegradable polymers useful in achieving controlled release of a drug, for example, polylactic acid, polyglycolic acid, copolymers of polylactic and polyglycolic acid, polyepsilon caprolactone, polyhydroxy butyric acid, polyorthoesters, polyacetals, polydihydropyrans, polycyanoacylates, and crosslinked or amphipathic block copolymers of hydrogels. Dosage forms (pharmaceutical compositions) suitable for administration may contain from about 1 milligram to about 100 milligrams of active ingredient per dosage unit. In these pharmaceutical compositions the active ingredient will ordinarily be present in an amount of about 0.5-95% by weight based on the total weight of the composition. The active ingredient can be administered orally in solid dosage forms, such as capsules, tablets, and powders, or in liquid dosage forms, such as elixirs, syrups, and suspensions. It can also be administered parenterally, in sterile liquid dosage forms. Gelatin capsules may contain the active ingredient and powdered carriers, such as lactose, starch, cellulose derivatives, magnesium stearate, stearic acid, and the like. Similar diluents can be used to make compressed tablets. Both tablets and capsules can be manufactured as sustained release products to provide for continuous release of medication over a period of hours. Compressed tablets can be sugar coated or film coated to mask any unpleasant taste and protect the tablet from the atmosphere, or enteric coated for selective disintegration in the gastrointestinal tract. Liquid dosage forms for oral administration can contain coloring and flavoring to increase patient acceptance. In general, water, a suitable oil, saline, aqueous dextrose (glucose) , and related sugar solutions and glycols such as propylene glycol or polyethylene glycols are suitable carriers for parenteral solutions. Solutions for parenteral administration preferably contain a water soluble salt of the active ingredient, suitable stabilizing agents, and if necessary, buffer substances. Antioxidizing agents such as sodium bisulfite, sodium sulfite, or ascorbic acid, either alone or combined, are suitable stabilizing agents. Also used are citric acid and its salts and sodium EDTA. In addition, parenteral solutions can contain preservatives, such as benzalkonium chloride, methyl- or propyl-paraben, and chlorobutanol. Suitable pharmaceutical carriers are described in Remington's Pharmaceutical Sciences. Mack Publishing Company, a standard reference text in this field. Representative useful pharmaceutical dosage-forms for administration of the compounds of this invention can be illustrated as follows: Capsules A large number of unit capsules are prepared by filling standard two-piece hard gelatin capsules each with 1-20 milligrams of powdered active ingredient, 150 milligrams of lactose, 50 milligrams of cellulose, and 6 milligrams magnesium stearate. soft gelatin sules A mixture of active ingredient in a digestable oil such as soybean oil, cottonseed oil or olive oil is prepared and injected by means of a positive displacement pump into gelatin to form soft gelatin capsules containing 1-20 milligrams of the active ingredient. The capsules are washed and dried. Tablets A large number of tablets are prepared by conventional procedures so that the dosage unit was 1-20 milligrams of active ingredient, 0.2 milligrams of colloidal silicon dioxide, 5 milligrams of magnesium stearate, 275 milligrams of microcrystalline cellulose, 11 milligrams of starch and 98.8 milligrams of lactose. Appropriate coatings may be applied to increase palatability or delay absorption. In-iectable A parenteral composition suitable for administration by injection is prepared by stirring 1.5% by weight of active ingredient in 10% by volume propylene glycol and water. The solution is made isotonic with sodium chloride and sterilized. Suspension An aqueous suspension is prepared for oral administration so that each 5 mL contain 1-20 mg of finely divided active ingredient, 200 mg of sodium carboxymethyl cellulose, 5 mg of sodium benzoate, 1.0 g of sorbitol solution, U.S.P., and 0.025 mL of vanillin. The compounds of the present invention may be administered in combination with a second therapeutic agent selected from: an anti-coagulant agent such as warfarin or heparin; an anti-platelet agent such as aspirin, piroxicam or ticlopidine; a thrombin inhibitor such as a boropeptide thrombin inhibitor, or hirudin; or a thrombolytic agent such as plasminogen activators, such as tissue plasminogen activator, anistreplase, urokinase or streptokinase. The compound of Formula I and such second therapeutic agent can be administered separately or as a physical combination in a single dosage unit, in any dosage form and by various routes of administration, as described above. The compound of Formula I may be formulated together with the second therapeutic agent in a single dosage unit (that is, combined together in one capsule, tablet, powder, or liquid, etc.). When the compound of Formula I and the second therapeutic agent are not formulated together in a single dosage unit, the compound of Formula I and the second therapeutic agent (anti-coagulant agent, anti-platelet agent, thrombin inhibitor, and/or thrombolytic agent) may be administered essentially at the same time, or in any order; for example the compound of Formula I may be administered first, followed by administration of the second agent (anti-coagulant agent, anti-platelet agent, thrombin inhibitor, and/or thrombolytic agent) . When not administered at the same time, preferably the administration of the compound of Formula I and the second therapeutic agent occurs less than about one hour apart. A preferable route of administration of the compound of Formula I is oral. Although it is preferable that the compound of Formula I and the second therapeutic agent (anti-coagulant agent, anti-platelet agent, thrombin inhibitor, and/or thrombolytic agent) are both administered by the same route (that is, for example, both orally) , if desired, they may each be administered by different routes and in different dosage forms (that is, for example, one component of the combination product may be administered orally, and another component may be administered intravenously) . The dosage of the compound of Formula I when administered alone or in combination with a second therapeutic agent may vary depending upon various factors such as the pharmacodynamic characteristics of the particular agent and its mode and route of administration, the age, health and weight of the recipient, the nature and extent of the symptoms, the kind of concurrent treatment, the frequency of treatment, and the effect desired, as described above. Although the proper dosage of the compound of Formula I when administered in combination with the second therapeutic agent will be readily ascertainable by a medical practitioner skilled in the art, once armed with the present disclosure, by way of general guidance, where the compounds of this invention are combined with anti-coagulant agents, for example, a daily dosage may be about 0.1 to 100 milligrams of the compound of Formula I and about 1 to 7.5 milligrams of the anticoagulant, per kilogram of patient body weight. For a tablet dosage form, the novel compounds of this invention generally may be present in an amount of about 1 to 10 milligrams per dosage unit, and the anti-coagulant in an amount of about 1 to 5 milligrams per dosage unit. Where the compounds of Formula I are administered in combination with a second anti-platelet agent, by way of general guidance, typically a daily dosage may be about 0.01 to 25 milligrams of the compound of Formula I and about 50 to 150 milligrams of the additional anti-platelet agent, preferably about 0.1 to 1 milligrams of the compound of Formula I and about 1 to 3 milligrams of anti- platelet agents, per kilogram of patient body weight. Further, by way of general guidance, where the compounds of Formula-I are adminstered in combination with thrombolytic agent, typically a daily dosage may be about 0.1 to 1 milligrams of the compound of Formula I, per kilogram of patient body weight and, in the case of the thrombolytic agents, the usual dosage of the thrombolyic agent when administered alone may be reduced by about 10- 80% when administered with a compound of Formula I. Where two or more of the foregoing second therapeutic agents are administered with the compound of Formula I, generally the amount of each component in a typical daily dosage and typical dosage form may be reduced relative to the usual dosage of the agent when administered alone, in view of the additive or synergistic effect of the therapeutic agents when administered in combination. Particularly when provided as a single dosage unit, the potential exists for a chemical interaction between the combined active ingredients. For this reason, when the compound of Formula I and a second therapeutic agent are combined in a single dosage unit they are formulated such that although the active ingredients are combined in a single dosage unit, the physical contact between the active ingredients is minimized (that is, reduced) . For example, one active ingredient may be enteric coated. By enteric coating one of the active ingredients, it is possible not only to minimize the contact between the combined active ingredients, but also, it is possible to control the release of one of these components in the gastrointestinal tract such that one of these components is not released in the stomach but rather is released in the intestines. One of the active ingredients may also be coated with a sustained-release material which effects a sustained-release throughout the gastrointestinal tract and also serves to minimize physical contact between the combined active ingredients. Furthermore, the sustained- released component can be additionally enteric coated such that the release of this component occurs only in the intestine. Still another approach would involve the formulation of a combination product in which the one component is coated with a sustained and/or enteric release polymer, and the other component is also coated with a polymer such as a lowviscosity grade of hydroxypropyl methylcellulose (HPMC) or other appropriate materials as known in the art, in order to further separate the active components. The polymer coating serves to form an additional barrier to interaction with the other component. These as well as other ways of minimizing contact between the components of combination products of the present invention, whether administered in a single dosage form or administered in separate forms but at the same time by the same manner, will be readily apparent to those skilled in the art, once armed with the present disclosure. The present invention also includes pharmaceutical kits useful, for example, in the inhibition of platelet aggregation, the treatment of blood clots, and/or the treatment of thromboembolic disorders, which comprise one or more containers containing a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I. Such kits may further include, if desired, one or more of various conventional pharmaceutical kit components, such as, for example, containers with one or more pharmaceutically acceptable carriers, additional containers, etc., as will be readily apparent to those skilled in the art. Instructions, either as inserts or as labels, indicating quantities of the components to be administered, guidelines for administration, and/or guidelines for mixing the components, may also be included in the kit. In the present disclosure it should be understood that the specified materials and conditions are important in practicing the invention but that unspecified materials and conditions are not excluded so long as they do not prevent the benefits of the invention from being realized.

Claims: PATENT APPLICATION DM-6685-B CLAIMS WHAT IS CLAIMED IS: A compound of Formula I: or pharmaceutically acceptable salt form thereof wherein: b is a carbon-carbon single or double bond; R 1 is selected from R 2 (R 3 )N(CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)CN(R 2 ) (CH 2 ) q Z-, piperazinyl- (CH 2 ) q Z- or Z is selected from O, S, S(=0), or S(=0) 2 ; R 2 and R 3 are independently selected from: H, C 1 -C 10 alkyl, C 2 -C 6 alkenyl, C 3 -C 11 cycloalkyl, C 4 -C 11 cycloalkylalkyl, Cg-Cio aryl, C 7 -C 11 arylalkyl, C 2 -C 7 alkylcarbonyl, Cg-Cio arylcarbonyl, C 2 -C 10 alkoxycarbonyl, C 4 -C 11 cycloalkoxycarbonyl, C 7 -C 11 bicycloalkoxycarbonyl, Cβ-Cio aryloxycarbonyl, aryl(C 1 -C 1 0 alkoxy)carbonyl, C 1 -C6 alkylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl, Cg-Cio arylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl, C 4 -C 11 cycloalkylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl; U is selected from: a single bond, -(C 1 -C 7 alkyl)-, -(C 2 -C 7 alkenyl) -(C 2 -C7 alkynyl)-, -(aryl)- substituted with 0-3 R 6a , or -(pyridyl)- substituted with 0-3 R 6a ; V is selected from: a single bond; -(C 1 -C 7 alkyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(C 2 -C 7 alkenyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(C 2 -C 7 alkynyl)-, substituted with 0-2 groups independently selected from R 6 or R 7 ; -(aryl)-, substituted with 0-2 groups independently selected from R 6 or R 7 ; -(pyridyl)-, substituted with 0-2 groups independently selected from R 6 or R 7 ; or -(pyridazinyl)-, substituted with 0-2 groups independently selected from R 6 or R 7 ; W is selected from: a single bond, -(C 1 -C7 alkyl)-, -(C 2 -C 7 alkenyl)-, -(C 2 -C7 alkynyl)-, or -(C(R 5 ) 2 )nC(=0)N(R 5a )-; X is selected from: a single bond; -(C 1 -C 7 alkyl)-, substituted with 0-3 groups independently selected from R 4 , R 8 or R 14 ; -(C 2 -C 7 alkenyl)-, substituted with 0-3 groups independently selected from R 4 , R 8 or R 14 ; - (C 2 -C 7 alkynyl)-, substituted with 0-2 groups independently selected from R 4 , R 8 or R 14 ; or Y is selected from hydroxy, Ci to Cio alkyloxy, C 3 to Cn cycloalkyloxy, Cβ to Cio aryloxy, C 7 to Cn aralkyloxy, C 3 to Cio alkylcarbonyloxyalkyloxy, C 3 to Cio alkoxycarbonyloxyalkyloxy, C 2 to Cio alkoxycarbonylalkyloxy, C5 to Cio cycloalkylcarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonyloxyalkyloxy, C 5 to Cio eyeloalkoxycarbonylalkyloxy, C 7 to Cn aryloxycarbonylalkyloxy, Cs to C 12 aryloxycarbonyloxyalkyloxy, Cs to C 12 arylcarbonyloxyaIkyloxy, C5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C5 to C o (5-alkyl- 1,3-dioxa-cyclopenten-2-one-yl)methyloxy, Cio to C 14 (5-aryl-l,3-dioxa-cyclopenten-2-one-yl)methyloxy; or (R 2 ) (R 3 )N-(Cι-Cιo alkoxy)-; R 4 and R b are independently selected from H, C 1 -C 10 alkyl, hydroxy, C 1 -C 1 0 alkoxy, nitro, C 1 -C 1 0 alkylcarbonyl, or -N(R 12 )R 13 ; R 5 is selected from H, Ci-Cs alkyl, C 2 -C 6 alkenyl, C 3 -C 11 cycloalkyl, C 4 -C 11 cycloalkylmethyl, C δ -Cio aryl, C 7 - Cn arylalkyl, or C 1 -C 10 alkyl substituted with 0-2 R 4 *>; R 5a is selected from hydrogen, hydroxy, Ci to Cs alkyl, C 2 to Cβ alkenyl, C 3 to Cn cycloalkyl, C 4 to Cn cycloalkylmethyl, Ci-Cε alkoxy, benzyloxy, Cβ to Cio aryl, heteroaryl, heteroarylalkyl, C 7 to Cn arylalkyl, adamantylmethyl or C 1 -C 10 alkyl substituted with 0-2 R 4b ; alternately, R 5 and R 5a can be taken together to be 3- azabicyclononyl, 1-piperidinyl, 1-morpholinyl or 1- piperazinyl, each being optionally substituted with Ci-Cβ alkyl, Cβ-Cio aryl, heteroaryl, C 7 -C11 arylalkyl, Ci-C δ alkylcarbonyl, C3-C7 cycloalkylcarbonyl, Ci-Cβ alkoxycarbonyl, C 7 -C 11 arylalkoxycarbonyl, C 1 -C6 alkylsulfonyl or C6-C10 arylsulfonyl; R 5b is selected from Ci-Cs alkyl, C 2 -C 6 alkenyl, C 3 -C 11 cycloalkyl, C 4 -C 11 cycloalkylmethyl, Cβ-Cio aryl, C 7 - C 11 arylalkyl, or C 1 -C 1 0 alkyl substituted with 0-2 R 4b ; R 6 is selected from H, C1-C1 0 alkyl, hydroxy, C1-C 10 alkoxy, nitro, C 1 -C 1 0 alkylcarbonyl, -N(R 12 )R 13 , cyano, halo, CF 3 , CHO, CO2R 5 , C(=0)R 5a , CONR 5 R 5a , OC(=0)R 5a , OC(=0)OR 5b , OR 5 , OC(=0)NR 5 R 5a , OCH 2 CO 2 R 5 , CO2CH2CO2R 5 , N0 2 , NR 5a C(=0)R 5 , NR 5a C(=0)OR 5b , NR 5 C(=0)NR 5 R 5a , NR 5a S0 2 NR 5 R 5a , NR 5 Sθ 2 R 5 , S(0) p R 5a , Sθ 2 NR 5 R 5 , C 2 to Cβ alkenyl, C 3 to Cn cycloalkyl, C 4 to Cn cycloalkylmethyl; C6 to Cio aryl optionally substituted with 1-3 groups selected from halogen, C1-C6 alkoxy, Ci-C δ alkyl, CF 3 , S(0)mMe, or -NMe2; C 7 to Cn arylalkyl, said aryl being optionally substituted with 1-3 groups selected from halogen, C 1 -C6 alkoxy, Ci-C δ alkyl, CF3, S(0)mMe, or -NMe2; methylenedioxy when R 6 is a substituent on aryl; or a 5-10 membered heterocyclic ring containing 1-3 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 7 ; R 6 is selected from C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , NO2, or NR 12 R 13 ; R 7 is selected from H, C1-C10 alkyl, hydroxy, C 1 -C1 0 alkoxy, nitro, C1-C 10 alkylcarbonyl, -N(R 12 )R 13 , cyano, halo, CF 3 , CHO, CO2R 5 , C(=0)R 5 , CONR 5 R 5a , OC(=0)R 5a , OC(=0)OR 5b , OR 5 , OC (=0)NR 5 R 5 , OCH 2 CO 2 R 5 , CO2CH2CO2R 5 , NO2, NR 5a C(=0)R 5a , NR 5a C(=0)OR 5b , NR 5a C(=0)NR 5 R 5 , NR 5a Sθ 2 NR 5 R 5a , NR 5 S0 2 R 5 , S(0) p R 5a , S0 2 NR 5 R 5a , C2 to Cβ alkenyl, C 3 to Cn cycloalkyl, C 4 to Cn cycloalkylmethyl, Cβ to Cio aryl, or C 7 to Cn arylalkyl; R 8 is selected from: H; R 6 ; C 1 -C 10 alkyl, substituted with 0-3 R 6 ; C 2 -C 10 alkenyl, substituted with 0-3 R 6 ; C2-C1 0 alkynyl, substituted with 0-3 R 6 ; C 3 -C 8 cycloalkyl, substituted with 0-3 R 6 ; C 5 -C6 cycloalkenyl, substituted with 0-2 R 6 ; aryl, substituted with 0-2 R 6 ; 5-10 membered heterocyclic ring containing 1-3 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 6 ; R 12 and R 13 are independently H, C1-C10 alkyl, C 1 -C 10 alkoxycarbonyl, C 1 -C 10 alkylcarbonyl, C 1 -C 10 alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, arylsulfonyl, aryl, C 2 -C 6 alkenyl, C 3 -C 11 cycloalkyl, C4-C11 cycloalkylalkyl, C7-C1 1 arylalkyl, C2-C7 alkylcarbonyl, C 7 -C 11 arylcarbonyl, C2-C 10 alkoxycarbonyl, C 4 -C 11 cycloalkoxycarbonyl, C 7 -C 11 bicycloalkoxycarbonyl, C 7 -C 11 aryloxycarbonyl, heteroarylcarbonyl, heteroaryisulfonyl, heteroarylalkylcarbonyl or aryl (C 1 -C10 alkoxy) carbonyl; R 14 is selected from H, C 1 -C 10 alkyl, C2-C 10 alkenyl, C2- C 10 alkynyl, C 1 -C 1 0 alkoxy, aryl, heteroaryl or C1-C10 alkoxycarbonyl, CO2R 5 or -C(=0)N(R 5 )R 5 ; R 15 is selected from: H; R 6 ; C 1 -C 1 0 alkyl, substituted with 0-8 R 6 ; C2-C 1 0 alkenyl, substituted with 0-6 R 6 ; C1-C1 0 alkoxy, substituted with 0-6 R 6 ; aryl, substituted with 0-5 R 6 ; 5-6 membered heterocyclic ring containing 1-2 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-5 R 6 ; C 1 -C 10 alkoxycarbonyl substituted with 0-8 R 6 ; CO2R 5 ; or -C(=0)N(R 5 )R 5 ; provided that when b is a double bond, only one of R 14 or R 15 is present; provided that n, q, and r are chosen such that the number of in-chain atoms between R 1 and Y is in the range of 8-18. 2. A compound of Claim 1 of Formula II: wherein : R 1 is selected from R 2 HN(CH 2 ) q O-, R 2 HN(R 2 N=)CNH(CH 2 ) q O-, piperazinyl-(CH 2 ) q O-, or R 2 is selected from H, aryl(Cι-Cιo alkoxy)carbonyl, Ci-Cio alkoxycarbonyl; R 8 is selected from H, Ci-Cio alkyl, C 2 -C 10 alkenyl, C3- Cβ cycloalkyl, C 5 -C 6 cycloalkenyl, aryl, 5-6 membered heterocyclic ring containing 1-2 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated; R 6 and R 7 are selected from H, C 1 -C 10 alkyl, hydroxy, C 1 -C 1 0 alkoxy, nitro, C 1 -C 1 0 alkylcarbonyl, -N(R 12 )R 13 , cyano, or halo. 3. A compound of Claim 2 wherein: X is selected from: a single bond; -(C 1 -C 7 alkyl)-, substituted with 0-2 groups independently selected from R 4 , R 8 or R 14 ; -(C 2 -C 7 alkenyl)-, substituted with 0-2 groups independently selected from R 4 , R 8 or R 14 ; -(C 2 -C 7 alkynyl)-, substituted with 0-2 groups independently selected from R 4 , R 8 or R 14 ; R 8 is selected from H, Ci-Cδ alkyl, C 2 -C6 alkenyl, C3-C8 cycloalkyl, C 5 -C 6 cycloalkenyl, aryl, 5-6 membered heterocyclic ring containing 1-2 N, 0, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated. 4. A compound of Claim 2 wherein: V is phenylene or pyridylene; n is 1 or 2; X is -(C 1 -C 2 )alkyl- substituted with 0-2 R 4 Y is selected from: hydroxy; Ci to Cio alkoxy; methylcarbonyloxymethoxy-; ethylcarbonyloxymethoxy-; t-butylcarbonyloxymethoxy-; cyclohexylcarbonyloxymethoxy-; 1-(methylcarbonyloxy)ethoxy-; 1-(ethylcarbonyloxy)ethoxy-; 1- (t-butylcarbonyloxy)ethoxy-; 1-(cyclohexylcarbonyloxy)ethoxy-; i-propyloxycarbonyloxymethoxy-; t-butyloxycarbonyloxymethoxy-; 1-(i-propyloxycarbonyloxy)ethoxy-; 1-(cyclohexyloxycarbonyloxy)ethoxy-; 1- ( t-butyloxycarbonyloxy)ethoxy-; dimethylaminoethoxy-; diethylaminoethoxy-; (5-methyl-l,3-dioxacyclopenten-2-on-4-yl)methoxy-; (5- (t-butyl)-l,3-dioxacyclopenten-2-on-4-yl)methoxy-; (1,3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methoxy-; 1- (2- (2-methoxypropyl)carbonyloxy)ethoxy-; R 4 is -NR 12 R 13 ; R 12 is H, C 1 -C 4 alkoxycarbonyl, C 1 -C 4 alkylcarbonyl, C 1 -C 4 alkylsulfonyl, arylalkylsulfonyl, heteroarylsulfonyl, arylsulfonyl, benzyl, benzoyl, phenoxycarbonyl, benzyloxycarbonyl, arylalkylsulfonyl, pyridylcarbonyl, or pyridylmethylcarbonyl; R 13 is F. 5. A compound of Claim 1, or a pharmaceutically acceptable salt form thereof, selected from: 5 (R, S)-3-[ [4- (2-piperidin-4-yl)ethoxyphenyl]isoxazolin-5- yl]acetic acid; 5 (R, S) -N-(butanesulfonyl)-L-{3-[4-(2-piperidin-4- yl)ethoxyphenyl]isoxazolin-5-yl)glycine; 5 (R, S) -N-(α-toluenesulfonyl)-L-{3-[4-(2-piperidin-4- y1)ethoxyphenyl]isoxazolin-5-yl}glycine; 5 (R, S) -N-[ (benzyloxy)carbonyl]- -{3-[4-(2-piperidin-4- yl)ethoxyphenyl]isoxazolin-5-yl)glycine; 5 (R, S) -N-(pentanoyl)-L-{3-[4- (2-piperidin-4-yl)ethox¬ yphenyl]isoxazolin-5-yl}glycine; 5 (R, S)-3-{ [4-(piperidin-4-yl)methoxyphenyl]isoxazolin-5- yDpropanoic acid; 2 (R, S)-5 (R, S) -N- (butanesulfonyl)amino-{3-[4-(piperidin-4- yl)methoxyphenyl]isoxazolin-5-yl}propanoic acid; 2 (R, S) -5 (R, S) -N- (α-toluenesulfonyl) amino-{3- [4- (piperi- din-4-yl)methoxyphenyl] isoxazolin-5-yl}propanoic acid; 2 (R, S) -5 (R, S) -N- [ (benzyloxy) carbonyl]amino-{3- [4- (piper- idin-4-yl)methoxyphenyl] isoxazolin-5-yl}propanoic acid; 2 (R, S) -5 (R, S) -N- (pentanoyl)amino-{3- [4- (piperidin-4- yl)methoxyphenyl] isoxazolin-5-yl}propanoic acid. 6. A compound of Formula I or a pharmaceutically acceptable salt form thereof wherein: b is a carbon-carbon single or double bond; R 1 is selected from R 2a (R 3 )N-, R 2 (R 3 )N(R 2 N=)C-, R 2a( R 3) N ( C H 2 ) qZ _ # R 2 ( R 3) N ( R 2 N= ) c ( CH2 ) gZ _ # R 2 (R 3 )N(R 2 N=)CN(R 2 ) -, R 2 (R 3 5NC {O) - , R 2 (R 5 0)N(R 2 N=)C- R 2 {R3)N(R 5 ON= )C-; Z is selected from: a bond, 0, S, S(=0), S(=0)2; R 2 and R 3 are independently selected from: H; Ci-Cio alkyl; C3-C6 alkenyl; C3-C11 cycloalkyl; C4-C11 cycloalkylalkyl; Cε-Cio aryl optionally substituted with 0-3 groups selectevi from hydroxy, halogen, Cι~Cg alkoxy, Ci-Ce alkyl, CF 3 , S(0) m CH3, -N(CH 3 ) , C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C7- Cn arylalkyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Cι~Ce alkoxy, Ci-Cg alkyl, CF 3 , S(0 ) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 2 -C7 alkylcarbonyl; C 7 -C 1 1 arylcarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, C -Cβ alkyl, CF 3 , S(0) m CH 2 , -N(CH3/2, C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 1 -C 10 alkoxycarbonyl; C 4 -C 11 cycloalkoxycarbonyl; C 7 -C 11 bicycloalkoxycarbonyl; C 7 - Cn aryloxycarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cβ alkyl, CF 3 , S(0)π»CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; aryl (C 1 -C 10 alkoxy) carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cρ alkoxy, Ci-Cg alkyl, CF 3 , S(0) K ,CH3, -N(CH3)2» C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; Ci-Cβ alkylcarbonyloxy(C1-C 4 alkoxy) carbonyl; Cε-Cio arylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, C1-C0 alkoxy, Ci-Cg alkyl, CF3, S(0) m CH 3 , -N(CH3) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 4 -C 11 cycloalkylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl; heteroaryl optionally substituted with 0-2 groups selected from hydroxy, halogen, 1 -C 0 alkoxy, 1 -C0 alkyl, CF 3 , 3ι ' 0) m CH 3 , -N103 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; or heteroaryl (C1-C 5 }alkyl where the heteroaryl group is optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-Cρ a ox , Cj-Cρ alkyl, CF 3 , S(0) m CH3, -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxy i 1, ethylenedioxydiyl; provided that only one of F: 2 and R 3 may be hydroxy; R 2a i s R 2 or R2( 3) N ( R 2 N= ) _. U is selected from: a single bond, -(C1-C 7 alkyl)—, -(C2-C7 alkenyl)-, -(C2-C7 alkynyl)-, -(aryl)- substituted with 0-3 R 6 , or -(pyridyl)- substituted with 0-3 R 6a ; V is selected from: _ a single bond; -(C 1 -C7 alkyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(C2-C7 alkenyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(C2-C 7 alkynyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; - (phenyl) -Q-, said phenyl substituted with 0-2 groups independently selected from R 6 or R 7 ; - (pyridyl) -Q-, said pyridyl substituted with 0-2 groups independently selected from R 6 or R 7 ; or - (pyridazinyl) -Q-, said pyridazinyl substituted with 0-2 groups independently selected from R 6 or R 7 » Q is selected from a single bond, -0-, -S(0) m -, -N(R 12 )-, -(CH2)πr. -C(=0)-, -N(R 5a )C(=0)-, -C(=0)N(R 5a )-, -CH2O-, -OCH2-, -CH 2 N(R 12 )-, -N(R 12 )CH -, -CH 2 C(=0)-, -C(=0)CH 2 -, -CH 2 S(0) m -, or -S(0) m CH 2 -, provided that when b is a single bond, and R 1 -U-V- is a substituent on C5 of the central 5-membered ring of Formula I, then Q is not -0-, -S(0) m -, -N(R 12 )-, . -C(=0)N(R 5a )-, -CH2O-, CH 2 N(R 12 )- or -CH 2 S(0) m -; W is selected from: -(C(R 4 ) 2 ) n C(=0)N(R 5a )-, or -C ( =0 ) -N ( R 5a) - ( C ( R ) 2 ) n-; X is selected from: a single bond, -(C(R 4 ) 2 )n-C(R 4 ) (R 8 )-C(R 4 ) (R a )-, with the proviso that when n is 0 or 1, then at least one of R a or R 8 is other than H or methyl; Y is selected from hydroxy, Ci to Cio alkyloxy, C 3 to Cn cycloalkyloxy, Cβ to Cio aryloxy, C7 to Cn aralkyloxy, C 3 to Cio alkylcarbonyloxyalkyloxy, C 3 to Cio alkoxycarbonyloxyalkyloxy, C 2 to Cio alkoxycarbonylalkyloxy, C 5 to Cio cycloalkylcarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonylalkyloxy, C 7 to Cn aryloxycarbonylalkyloxy, Cs to C 12 aryloxycarbonyloxyalkyloxy, Cs to C 12 arylcarbonyloxyalkyloxy, C 5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C 5 to Cio (5-alkyl- 1,3-dioxa-cyclopenten-2-one-yl)methyloxy, Cio to C 14 (5-aryl-l,3-dioxa-cyclopenten-2-one-yl)methyloxy, (R 2 ) (R 3 )N-(Cι-Cιo alkoxy)-; R 4 is selected from H, C 1 -C 1 0 alkyl, C 1 -C 1 0 alkylcarbonyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; alternately, two R 4 groups on adjacent carbon atoms may join to form a bond thereby to form a carbon-carbon double or triple bond between such adjacent carbon atoms; R 4a is selected from H, hydroxy, C 1 -C 1 0 alkoxy, nitro, N(R 5 )R 5a , -N(R 12 )R 13 , -N(R 16 )R 17 , C 1 -C 10 alkyl substituted with 0-3 R β , aryl substituted with 0-3 R 6 , or C 1 -C 10 alkylcarbonyl; R 4b is selected from H, C 1 -C6 alkyl, C 2 -C6 alkenyl, C 2 -C6 alkynyl, C 3 -C 7 cycloalkyl, C7-C 14 bicycloalkyl, hydroxy, Ci-Ce alkoxy, Ci-Cβ alkylthio, Ci-Cδ alkylsulfinyl, Ci-Cβ alkylsulfonyl, nitro, Ci-Cβ alkylcarbonyl, C δ -Cio aryl, -N(R 12 )R 13 ; halo, CF3, CN, Ci-C δ alkoxycarbonyl, carboxy, piperidinyl, morpholinyl or pyridinyl; R 5 is selected from H, Ci-Cs alkyl, C3-C6 alkenyl, C3-C11 cycloalkyl, C 4 -C 11 cycloalkylmethyl, C6-C 1 0 aryl, C 7 - C11 arylalkyl, or C1-C1 0 alkyl substituted with 0-2 R 4b ; R 5 a s selected from hydrogen, hydroxy, Ci to Cs alkyl, C 3 - Cβ alkenyl, C3 to Cn cycloalkyl, C4 to Cn cycloalkylmethyl, Ci-Cε alkoxy, benzyloxy, C 6 to Cio aryl, heteroaryl, heteroarylalkyl, C 7 to Cn arylalkyl, adamantylmethyl, or C 1 -C 10 alkyl substituted with 0-2 R 4b ; alternately, R 5 and R 5a when both are substituents on the same nitrogen atom (as in -NR 5 R 5a ) can be taken together with the nitrogen atom to which they are attached to form 3-azabicyclononyl, 1,2,3,4- tetrahydro-1-quinolinyl, 1,2, 3,4-tetrahydro-2- isoquinolinyl, 1-piperidinyl, 1-morpholinyl, 1- pyrrolidinyl, thiamorpholinyl, thiazolidinyl or 1- piperazinyl, each being optionally substituted with Ci-C δ alkyl, Cβ-Cio aryl, heteroaryl, C 7 -C 11 arylalkyl, Ci-Cβ alkylcarbonyl, C 3 -C 7 eyeloalkylcarbonyl, Ci-Cβ alkoxycarbonyl, C 7 -C1 1 arylalkoxycarbonyl, Ci-Cβ alkylsulfonyl or Cβ-Cio arylsulfonyl; R 5b is selected from Ci-Cs alkyl, C2-C 6 alkenyl, C3-C 11 cycloalkyl, C 4 -C1 1 cycloalkylmethyl, C 6 -C 10 aryl, C 7 - Cn arylalkyl, or C 1 -C 10 alkyl substituted with 0-2 R 4b ; R 6 is selected from H, C 1 -C10 alkyl, hydroxy, C 1 -C 10 alkoxy, nitro, C1-C10 alkylcarbonyl, -N(R 12 )R 13 , cyano, halo, CF 3 , CHO, CO 2 R 5 , C(=0)R 5 , C0NR 5 R 5a , OC(=0)R 5 , OC(=0)OR 5b , OR 5a , OC (=0)NR 5 R 5a , 0CH 2 C0 2 R 5 , CO 2 CH 2 CO2R 5 , NO2, NR 5 C(=0)R 5a , NR 5 C(=0)OR 5b , NR 5 C(=0)NR 5 R 5 , NR 5 S0 2 NR 5 R 5a , NR 5a Sθ2R 5 , S(0) p R 5 , Sθ2NR 5 R 5a , SiMe 3 , C 2 to Cg alkenyl, C 3 to Cn cycloalkyl, C 4 to Cn cycloalkylmethyl; Cg to Cio aryl optionally substituted with 1-3 groups selected from halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0)m e, or -NMe 2 ; C7 to Cn arylalkyl, said aryl being optionally substituted with 1-3 groups selected from halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0)mMe, or -NMβ 2 ; methylenedioxy when R 6 is a substituent on aryl; or a 5-10 membered heterocyclic ring containing 1-3 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 7 ; R 6 is selected from C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , NO 2 , or NR 12 R 13 ; R 7 is selected from H, C 1 -C 10 alkyl, hydroxy, C 1 -C 1 0 alkoxy, nitro, C 1 -C 1 0 alkylcarbonyl, -N(R 12 )R 13 , cyano, halo, CF3, CHO, CO 2 R 5 , C(=0)R 5a , CONR 5 R 5 , OC(=0)R 5 , OC(=0)OR 5b , OR 5a , OC(=0)NR 5 R 5 , OCH 2 CO 2 R 5 , CO 2 CH 2 CO 2 R 5 , NO 2 , NR 5a C(=0)R 5a , NR 5a C(=0)OR 5b , NR 5 C(=0)NR 5 R 5a , NR 5 Sθ 2 NR 5 R 5 , NR 5 S0 2 R 5 , S(0) p R 5a , Sθ 2 NR 5 R 5a , C 2 to Cg alkenyl, C 3 to Cn cycloalkyl, C 4 to Cn cycloalkylmethyl, Cg to Cio aryl, or C 7 to Cn arylalkyl; R 8 is selected from: R 6 ; C 1 -C 10 alkyl, substituted with 0-3 R 6 ; C 2 -C 1 0 alkenyl, substituted with 0-3 R 6 ; C 2 -C 10 alkynyl, substituted with 0-3 R 6 ; C 3 -C 8 cycloalkyl, substituted with 0-3 R 6 ; C δ -C cycloalkenyl, substituted with 0-3 R 6 ; aryl, substituted with 0-3 R 6 ; 5-10 membered heterocyclic ring containing 1-3 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 6 ; R 12 and R 13 are independently H, Ci-Cio alkyl, Ci-Cio alkoxycarbonyl, Ci-Cio alkylcarbonyl, Ci-Cio alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, arylsulfonyl, aryl(C2-Cιo alkenyl)sulfonyl, heteroarylsulfonyl, aryl, C2~C alkenyl, C 3 -C 11 cycloalkyl, C 4 -C11 cycloalkylalkyl, C7-C11 arylalkyl, C7-C11 arylcarbonyl, C4-C11 cycloalkoxycarbonyl, C 7 - C 11 bicycloalkoxycarbonyl, C 7 -C 11 aryloxycarbonyl, heteroarylcarbonyl, he eroaryisulfony1, heteroarylalkylcarbonyl, or aryl (C1-C 1 0 alkoxy) carbonyl, wherein said aryl groups are optionally substituted with 0-3 substituents selected from the group consisting of: C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, CF3, and NO2; R 14 is selected from H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C2- C10 alkynyl, C 1 -C 10 alkoxy, aryl, heteroaryl or C1-C10 alkoxycarbonyl, CO 2 R 5 or -C (=0)N(R 5 )R 5a ; R 15 is selected from: H; R 6 ; -CO 2 R 5 ; -C (=0)N(R 5 )R 5a ; C1-C10 alkoxycarbonyl substituted with 0-2 R 6 ; C1-C10 alkyl, substituted with 0-3 R 6 ; C2-C10 alkenyl, substituted with 0-3 R 6 ; C 1 -C1 0 alkoxy, substituted with 0-3 R 6 ; aryl, substituted with 0-3 R 6 ; or 5-10 membered heterocyclic ring containing 1-3 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 6 ; provided that when b is a double bond, only one of R 14 or R 15 is present; R 16 is selected from: -C(=0)-0-R 18a , -C(=0)-R 18b , -C(=0)N(R 18b ) 2 , -C(=0)NHS02R 18a , -C(=0)NHC(=0)R 18b , -C(=0)NHC(=0)OR 18a , -C (=0)NHS02NHR 18b , -C(=S)-NH-R 18b , -NH-C(=0)-0-R 18a , -NH-C(=0)-R 18b , -NH-C (=0) -NH-R 18b , -Sθ2-0-R 18a , -Sθ2-R 18a , -S0 2 -N(18 b ) 2 , -S0 2 -NHC(=0)018 b , R 17 is selected from: H, Ci-Cio alkyl, C 2 ~Cg alkenyl, C 3 -C 11 cycloalkyl, C 4 -C 1 5 cycloalkylalkyl, aryl, aryl(Cι-Cιo alkyl)-; R 18a is selected from: Ci-Cs alkyl substituted with 0-2 R 19 , C 2 -C 8 alkenyl substituted with 0-2 R 19 , C 2 -C 8 alkynyl substituted with 0-2 R 19 , C 3 -C 8 cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-4 R 19 , aryl(Cι-Cg alkyl)- substituted with 0-4 R 19 , a 5-10 membered heterocyclic ring system having 1-3 heteroatoms selected independently from 0, S, and N, said heterocyclic ring being substituted with 0-4 R 19 , Ci-Cg alkyl substituted with a 5-10 membered heterocyclic ring system having 1-3 heteroatoms selected independently from 0, S, and N, said heterocyclic ring being substituted with 0-4 R 19 ; R 18b is selected from R 18 or H; 19 is selected from H, halogen, CF 3 , CN, O 2 , NR 12 R 13 , Ci- Cs alkyl, C 2 -C6 alkenyl, C 2 -Cg alkynyl, C3-C 11 cycloalkyl, C 4 -C 11 cycloalkylalkyl, aryl, aryl(Cι-Cg alkyl)-, Ci-Cg alkoxy, or C 1 -C 4 alkoxycarbonyl; n is 0-4, q is 1-7, r is 0-3, provided that n, q and r are chosen such that the number of in-chain atoms connecting R 1 and Y is in the range of 8-18. 7. A compound of Claim 6 of Formula la: wherein: Z is selected from a bond, 0, or S; R 2 is selected from H, aryl(Cι-Cιo alkoxy)carbonyl, or C 1 -C 10 alkoxycarbonyl; W is -(CH 2 ) n C(=0)N(R 5 )-; X is -(C(R 4 ) 2 ) n "C(R 4 ) (R 8 )-CH(R 4 )-, with the proviso that when n is 0 or 1, then at least one of R a or R 8 is other than H or methyl; R 5 is selected from H or C 1 -C 1 0 alkyl substituted with 0-6 R 4b ; R 6 is selected from H, Ci-Cio alkyl, hydroxy, Ci-Cio alkoxy, nitro, Ci-Cio alkylcarbonyl, -N(R 12 )R 13 , -NR 5 R 5a , C0 2 R 5 , S(0) m R 5 , OR 5 , cyano, halo; Cg to Cio aryl optionally substituted with 1-3 groups selected from halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0)mMe, or -NMe2; C7 to Cn arylalkyl, said aryl being optionally substituted with 1-3 groups selected from halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF3, S(0)mMe, or -NMe 2 ; methylenedioxy when R 6 is a substituent on aryl; or a 5-10 membered heterocyclic ring containing 1-3 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 7 ; R 7 is selected from selected from H, C 1 -C 10 alkyl, hydroxy, C 1 -C 1 0 alkoxy, nitro, C 1 -C 10 alkylcarbonyl, -N(R 12 )R 13 , cyano, or halo; R 8 is selected from: -CONR 5 NR 5 ; -CO 2 R 5 ; C 1 -C 10 alkyl, substituted with 0-3 R 6 ; C 2 -C 1 0 alkenyl, substituted with 0-3 R 6 ; C 2 -C 1 0 alkynyl, substituted with 0-3 R 6 , C 3 -C 8 cycloalkyl, substituted with 0-3 R 6 ; C 5 -C cycloalkenyl, substituted with 0-3 R 6 ; aryl, substituted with 0-2 R 6 ; 5-10 membered heterocyclic ring containing 1-3 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 6 ; R 12 and R 13 are each independently selected from H, Ci-Cio alkyl, Ci-Cio alkoxycarbonyl, Ci-Cio alkylcarbonyl, Ci-Cio alkylsulfonyl, aryl(Cι-Cιo alkyl) sulfonyl, arylsulfonyl, aryl, heteroarylcarbonyl, heteroarylsulf.onyl , or heteroarylalkylcarbonyl, wherein said aryl groups are optionally substituted with 0-3 substituents selected from the group consisting of: C 1 -C4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , and NO2. 8. A compound of Claim 7 wherein: Z is selected from a bond or O; W is -(CH 2 ) n C(=0)N(R 12 )-; X is -C ( R 4 ) ( R 8) -C(R ) 2 -. 9. A compound of Claim 7 wherein: R 1 is R 2 NHC(=NR 2 )- or R 2 NHC(=NR 2 )NH- and V is phenylene or pyridylene, or R 1 and V is a single bond; n is 1 or 2; X is -CHR 8 CH2-; Y is selected from: hydroxy; Ci to Cio alkoxy; methylcarbonyloxymethoxy-; ethylcarbonyloxymethoxy-; t-butylcarbonyloxymethoxy-; cyclohexylcarbonyloxymethoxy-; 1- (methylcarbonyloxy)ethoxy-; 1- (ethylcarbonyloxy)ethoxy-; 1- (t-butylcarbonyloxy) ethoxy-; 1- (cyclohexylcarbonyloxy)ethoxy-; i-propyloxycarbonyloxymethoxy-; t-butyloxycarbonyloxymethoxy-; 1-(i-propyloxycarbonyloxy)ethoxy-; 1-(cyclohexyloxycarbonyloxy)ethoxy-; 1-( -butyloxycarbonyloxy)ethoxy-; dimethylaminoethoxy-; diethylaminoethoxy-; (5-methyl-l,3-dioxacyclopenten-2-on-4-yl)methoxy-; (5- ( -butyl)-1,3-dioxacyclopenten-2-on-4-yl)methoxy-; (1,3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methoxy-; 1- (2-(2-methoxypropyl)carbonyloxy)ethoxy-; R 6 is selected from H, C 1 -C 4 alkyl, hydroxy, C 1 -C 4 alkoxy, nitro, C 1 -C 1 0 alkylcarbonyl, -N(R 12 )R 13 , -NR 5 R 5a , CO 2 R 5 , S(0) m R 5 , OR 5 , cyano, halo; Cg to Cio aryl optionally substituted with 1-3 groups selected from halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0)m e, or -NMe 2 ; methylenedioxy when R 6 is a substituent on aryl; or a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, .pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, isoxazolyl, isoxazolinyl or morpholinyl; R 8 is selected from: -CONR 5 NR 5a ; -CO 2 R 5 ; C 1 -C 10 alkyl, substituted with 0-3 R 6 ; C 2 -C 10 alkenyl, substituted with 0-3 R 6 ; C 2 -C 10 alkynyl, substituted with 0-3 R 6 , C 3 -Cβ cycloalkyl, substituted with 0-3 R 6 ; aryl, substituted with 0-2 R 6 ; a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, isoxazolyl isoxazolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-2 R 6 ; R 12 is selected from H, Ci-Cg alkyl, C 1 -C 4 alkoxycarbonyl, Ci-Cg alkylcarbonyl, Ci-Cg alkylsulfonyl, aryl (C 1 -C 4 alkyl)sulfonyl, arylsulfonyl, aryl, heteroarylsulfonyl, pyridylcarbonyl or pyridylmethylcarbonyl, wherein said aryls are optionally substituted with 0-3 substituents selected from the group consisting of: C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, CF3, and NO 2 ; and R 13 is H. 10. A compound of Claim 6, or a pharmaceutically acceptable salt form thereof, selected from: 3 (R, S)-{5 (R, S)-N-[3-(4-amidinophenyl)isoxazolin-5- ylacety1]amino}-3-phenylpropanoic acid; 3 (R, S)-{5 (R, S)-N-[3-(4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-pentanoic acid; 3 (R)-{5 (R, S) -N- [ 3-(4-amidinophenyl)isoxazolin-5- ylacetyl]amino}heptanoic acid; 3 (R, S)-{5 (R, S) -N-[3-(4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-4-(phenylthio)butanoic acid; 3 (R, S)-{5 (R, S)-IV-[3-(4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-4-(phenylsulfonamido)butanoic acid; 3 (R, S)-{5 (R, S) -N-[3-(4-amidinopheny1)isoxazolin-5- ylacetyl]amino}-4-(n-butylsulfonamido)butanoic acid; 3 (S) -{5 (R, S)-N-[3-(4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-3- (adamantylmethylaminocarbonyl)propanoic acid; 3 (S) -{5 (R, S) -N- [3- (4-amidinophenyl) isoxazolin-5- ylacetyl]amino}-3- (1- azabicyclo[3.2.2]nonylcarbonyl)propanoic acid; 3 (S) -{5 (R, S) -N- [3- (4-amidinophenyl) isoxazolin-5- ylacetyl]amino}-3- (phenethylaminocarbonyl)propanoic acid. 3 (R) - { 5 (R, S) -N- [ 3- (4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-3- (3-pyridylethyl)propanoic acid. 3 (R) -{5 (R, S)-N- [3- (4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-3- (2-pyridylethyl)propanoic acid. 3 (R) -{5 (R, S) -N- [3- (4-amidinophenyl)isoxazolin-5- ylacetyl]amino}-3- (phenylpropyl)propanoic acid. 11. A compound of Claim 6 of Formula Ic: (ic) wherein: b is a carbon-carbon single bond; R 1 is selected from R 2a (R 3 )N-, R 2 (R 3 )N(R 2 N=)C-, R 2 (R 3 )N(CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)C(CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)CN(R 2 ) -, R 2 (R 3 )NC(O) -, R 2 (R 5 0)N(R 2 N=)C- R 2 (R 3 )N(R 5 ON=)C-; Z is selected from a bond, 0, or S; R 2 and R 3 are independently selected from: H; Ci-Cg alkyl; C7-C 1 1 arylalkyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cβ alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 > 2 , C 1 -C 4 haloalkyl, ' methylenedioxydiyl, ethylenedioxydiyl; C 1 -C 1 0 alkoxycarbonyl; aryl(Cι-Cιo alkoxy)carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Cχ-Cg alkoxy, Cχ-Cg alkyl, CF3, S(0) rtl CH3, - (013)2, C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; or heteroaryl (C1-C5)alkyl where the heteroaryl group is optionally substituted with 0-2 groups selected from hydroxy, halogen, Cj-Cg alkoxy, Cj-Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; R 2a is R 2 or R2(R3) N ( R 2 N= ) C . U is a single bond, V is selected from: a single bond; -(C 1 -C 7 alkyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(C2-C7 alkenyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(C2-C7 alkynyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; - (phenyl) -Q-, said phenyl substituted with 0-2 groups independently selected from R 6 or R 7 ; - (pyridyl) -Q-, said pyridyl substituted with 0-2 groups independently selected from R 6 or R 7 ; or - (pyridazinyl) -Q-, said pyridazinyl substituted with 0-2 groups independently selected from R 6 or R 7 - Q is selected from a single bond, -0-, -S(0) m -, -N(R 12 )-, -(CH 2 )m-, -C(=0)-, -N(R 5a )C(=0)-, -C(=0)N(R 5a )-, -CH 2 O-, -OCH 2 -, -CH 2 N(R 12 )-, -N(R 12 )CH 2 -, -CH 2 C(=0)-, -C(=0)CH 2 -, -CH 2 S(0) m -, or -S(0) m CH 2 -, provided that when b is a single bond, and R 1 -U-V- is a substituent on C5 of the central 5-membered ring of Formula Ic, then Q is not -0-, -S(0) m -, -N(R 12 )-, -C(=0)N(R 5a )-, -CH 2 0-, CH 2 N(R 12 )- or -CH 2 S(0) m -; W is selected from: -(C(R ) 2 )-C(=0)-N(R 5a )-, or -C(=0)-N(R 5a )- ( C ( R ) 2 ) -; X is -C(R 4 ) 2 ~CHR 4 -; R 4 is selected from H, Ci-Cio alkyl, Ci-Cio alkylcarbonyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; R a is selected from hydroxy, Ci-Cio alkoxy, nitro, -N(R 5 )R 5 , -N(R 12 )R 13 , or -N(R 16 )R 17 , Ci-Cio alkyl substituted with 0-3 R 6 , aryl substituted with 0-3 R 6 , or Ci-Cio alkylcarbonyl; R b is selected from H, Ci-Cg alkyl, C 2 -Cg alkenyl, C 2 ~Cg alkynyl, hydroxy, Ci-Cg alkoxy, Ci-Cg alkylthio, Ci-Cg alkylsulfinyl, Ci-Cg alkylsulfonyl, nitro, Ci-Cg alkylcarbonyl, Cg-Cio aryl, -N(R 12 )R 13 , halo, CF 3 , CN, Ci-Cg alkoxycarbonyl, carboxy, piperidinyl, morpholinyl or pyridyl; R 5 is selected from H or Ci-Cio alkyl substituted with 0-6 R 4b ; R 5a is selected from hydrogen, hydroxy, Ci to Cs alkyl, C 2 to Cg alkenyl, C 3 to Cn cycloalkyl, C 4 to Cn cycloalkylmethyl, Ci-Cg alkoxy, benzyloxy, Cg to Cio aryl, heteroaryl, heteroarylalkyl, C 7 to Cn arylalkyl, or adamantylmethyl, C 1 -C 1 0 alkyl substituted with 0-2 R 4b ; alternately, R 5 and R 5a can be taken together to be 3- azabicyclononyl, 1,2,3,4-tetrahydro-l-quinolinyl, 1,2,3,4-tetrahydro-2-isoquinolinyl, 1-piperidinyl, 1- morpholinyl, 1-pyrrolidinyl, thiamorpholinyl, thiazolidinyl or 1-piperazinyl, each being optionally substituted with Ci-Cg alkyl, Cg-Cio aryl, heteroaryl, C7-C11 arylalkyl, Ci-Cg alkylcarbonyl, C 3 -C7 cycloalkylcarbonyl, Ci-Cg alkoxycarbonyl or C7-C11 arylalkoxycarbonyl; R 5b is selected from Ci-Cs alkyl, C2-Cg alkenyl, C3-C11 cycloalkyl, C4-G 11 cycloalkylmethyl, Cg-Cio aryl, C 7 - C 11 arylalkyl, or C 1 -C 1 0 alkyl substituted with 0-2 R 4b Y is selected from hydroxy, Ci to Cio alkyloxy, C 3 to Cn cycloalkyloxy, Cg to Cio aryloxy, C 7 to Cn aralkyloxy, C 3 to Cio alkylcarbonyloxyalkyloxy, C 3 to Cio alkoxycarbonyloxyalkyloxy, C 2 to Cio alkoxycarbonylalkyloxy, C 5 to Cio cycloalkylcarbonyloxyalkyloxy, C5 to Cio cycloalkoxycarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonylalkyloxy, C 7 to Cn aryloxycarbonylalkyloxy, Cs to C 12 aryloxycarbonyloxyalkyloxy, Cs to C 1 2 arylcarbonyloxyalkyloxy, C 5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C 5 to Cio (5-alkyl- 1,3-dioxa-cyclopenten-2-one-yl)methyloxy, or Cio to C 1 4 (5-aryl-l,3-dioxa-cyclopenten-2-one-yl)methyloxy; R 6 and R 7 are each independently selected from H, C1-C 10 alkyl, hydroxy, C1-C 10 alkoxy, nitro, C1-C10 alkylcarbonyl, -N(R 1 )R 13 , cyano, or halo; R 12 and R 13 are each independently selected from H, C 1 -C 10 alkyl, C 1 -C 1 0 alkoxycarbonyl, C 1 -C 10 alkylcarbonyl, C 1 -C 10 alkylsulfonyl, aryl(Cι-Cιo alkyl) sulfonyl, arylsulfonyl, heteroarylsulfonyl, heteroarylcarbonyl, heteroarylalkylcarbonyl or aryl, wherein said aryl groups being optionally substituted with 0-3 substituents selected from the group consisting of: C1-C4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , and NO2; R 15 is selected from H, C 1 -C 1 0 alkyl, C2-C 1 0 alkenyl, C2- C1 0 alkynyl, C1-C 10 alkoxy, aryl, heteroaryl or C 1 -C 10 alkoxycarbonyl, CO 2 R 5 or -C (=0)N(R 5 )R 5a ; R 16 is selected from: -C(=0)-0-R 18 , -C(=0)-R 18b , -C ( =0 ) N ( R 18b) 2 , -S02-R 18a , or -S0 2 -N ( R 18b ) 2 ; R 17 is selected from: H or C 1 -C 4 alkyl l8a i s selected from: Ci-Cs alkyl substituted with 0-2 R 19 , C2-C 8 alkenyl substituted with 0-2 R 19 , C2-C 8 alkynyl substituted with 0-2 R 19 , C 3 -C δ cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-4 R 19 , aryl(Cι-Cg alkyl)- substituted with 0-4 R 19 , a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl,. pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, isoxazolyl, isoxazolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyrimidinyl, 3H-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-4 R 19 ; Ci-Cg alkyl substituted with a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, isoxazolinyl, benzofuranyl, indolyl, indolenyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, indolyl, carbazole, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-4 R 19 ; R 18b is selected from R 18a or H; 19 is selected from H, halogen, CF 3 , CN, NO 2 , NR 12 R 13 , Ci- Cβ alkyl, C2~Cg alkenyl, C2-C6 alkynyl, Ci-Cg alkoxy, C 3 -Cn cycloalkyl, C 4 -C 11 cycloalkylalkyl, aryl, heteroaryl, aryl(Ci-Cg alkyl)-, (C 1 -C 4 alkϊy)sulfonyl, aryl-sulfonyl, or C 1 -C 4 alkoxycarbonyl; n is 0-4, q is 1-7; r is 0-3, provided that n, q, and r are chosen such that the number of in-chain atoms between R 1 and Y is in the range of 8-17. 12. A compound of Claim 11 of Formula lb: (lb) wherein: b is a carbon-carbon single bond; R 1 is selected from: R 2 <R 3 )N-, R 2 NH(R 2 N=)C-, R 2 NH(R 2 N=)CNH-, R 2 R 3 N (CH )p- Z-, R 2 NH (R 2 N=)CNH (CH 2 ) p»Z-, R 2 ( R 3 ) NC ( 0 ) - , R 2 { R 5 0 ) N ( R 2 N= ) C - . R 2 { R 3 ) N ( R 5 ON= ) C - ; W is selected from: -(C(R ) 2 )-C(=0)-N(R 5 )-, -C(=0)-N(R 5a )-CH 2 -; X is selected from: -CH 2 -CHN(R 16 )R 17 -, or -CH 2 -CHNR 5 R 5 -; Y is selected from: hydroxy; Ci to Cio alkoxy; methylcarbonyloxymethoxy-; ethylcarbonyloxymethoxy-; t-butylcarbonyloxymethoxy-; cyclohexylcarbonyloxymethoxy-; 1-(methylcarbonyloxy)ethoxy-; 1-(ethylcarbonyloxy)ethoxy-; 1-(t-butylcarbonyloxy)ethoxy-; 1- (cyclohexylcarbonyloxy)ethoxy-; i-propyloxycarbonyloxymethoxy-; t-butyloxycarbonyloxymethoxy-; 1-(i-propyloxycarbonyloxy)ethoxy-; 1-(cyclohexyloxycarbonyloxy)ethoxy-; 1-( t-butyloxycarbonyloxy)ethoxy-; dimethylaminoethoxy-; diethylaminoethoxy-; (5-methyl-l,3-dioxacyclopenten-2-on-4-yl)methoxy-; (5-( -butyl)-1,3-dioxacyclopenten-2-on-4-yl)methoxy-; (1,3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methoxy-; 1-(2-(2-methoxypropyl)carbonyloxy)ethoxy-; R 16 is selected from: -C(=0)-0-R 18 , -C(=0)-R 18b , -S(=0)2-R 18a or -S0 2 -N(R 18b) 2 ; R 17 is selected from H or C 1 -C 5 alkyl; R 18a is selected from: Ci-Cs alkyl substituted with 0-2 R 19 , C 2 -C 8 alkenyl substituted with 0-2 R 19 , C 2 -C 8 alkynyl substituted with 0-2 R 19 , C 3 -Cβ cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-4 R 19 , aryl(Cι-Cg alkyl)- substituted with 0-4 R 19 , a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, isoxazolyl, isoxazolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyrimidinyl, 3H-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-4 R 19 ; Ci-Cg alkyl substituted with a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, isoxazolinyl, benzofuranyl, indolyl, indolenyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, indolyl, carbazole, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-4 R 19 . 13. A compound of Claim 11 wherein: R 1 is R 2 NH(R 2 N=)C- or R 2 HN(R 2 N=)CNH- and V is phenylene or pyridylene, or R 1 is and V is a single bond; n is 1 or 2; R l8a is selected from: C 1 -C 4 alkyl substituted with 0-2 R 19 , C 2 -C 4 alkenyl substituted with 0-2 R 19 , C 2 -C 4 alkynyl substituted with 0-2 R 19 , C 3 -C 7 cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-4 R 19 , aryl(Cι-C 4 alkyl)- substituted with 0-4 R 19 , a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, isoxazolyl, isoxazolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyrimidinyl, 3H-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, isoxazolinyl or morpholinyl, said heterocyclic ring being substituted with 0-4 R 19 ; C 1 -C 4 alkyl substituted with a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, isoxazolinyl, benzofuranyl, indolyl, indolenyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, indolyl, carbazole, pyrrolidinyl, piperidinyl, indolinyl, isoxazolinyl or morpholinyl, said heterocyclic ring being substituted with 0-4 R l9 . 14. A compound of Claim 6, or pharmaceutically acceptable salt forms thereof, selected from: N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (phenylsulfonyl)-2,3-(S)-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5(i^S^-yl¬ acetyl]-N2- (4-methyl-phenyl-sulfonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5(J?,SJ-yl¬ acetyl]-N2- (butanesulfonyl)-2,3-(S)-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinopheny1)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (propanesulfonyl)-2,3- (S) -diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S ) -yl} - acetyl]-N2- (ethanesulfonyl)-2,3-(S)-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(methyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinopheny1)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(ethyloxycarbonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(1-propyloxycarbonyl)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(2-propyloxycarbonyl)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} - acetyl]-N2-(n-butyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R) -yl} - acetyl]-N2-(n-butyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5(5^-yl}- acetyl]-N2- (n-butyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R) -yl} - acetyl]-N2-(n-butyloxycarbonyl)-2,3-(R)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (S) -yl ) - acetyl]-N2-(n-butyloxycarbonyl)-2,3-(R)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl } - acetyl]-N2-(2-butyloxycarbonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} - acetyl]-N2- (1-(2-methyl)-propyloxycarbonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5(!?,_?,>-yl¬ acetyl]-N2- (2- (2-methyl)-propyloxycarbonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} - acetyl]-N2-(benzyloxycarbonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R) -yl} - acetyl]-N2-(benzyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (S) -yl} - acetyl]-N2-(benzyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} - acetyl]-N2-(4-methylbenzyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(4-methoxybenzyloxycarbony1)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (4-chlorobenzyloxycarbonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(4-bromobenzyloxycarbony1)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S)-yl}- acetyl]-N2- (4-fluorobenzyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (4-phenoxybenzyloxycarbony1)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}~ acetyl]-N2- (2-(methyloxyethyl)-oxycarbonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}~ acetyl]-N2-(2-pyridinylcarbony1)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}~ acety1]-N2-(3-pyridinylcarbony1)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S) -yl}- acetyl]-N2-(4-pyridinyl-carbonyl)-2,3-(S)- diaminopropanoic acid; N 3 - [2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S) -yl}- acetyl]-N2- (2-(2-pyridinyl)-acetyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl)- acetyl]-N2- (2-(3-pyridinyl)-acetyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S )-yl}- acetyl]-N2- (2-(4-pyridinyl)-acetyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}~ acetyl]-N2- (2-pyridyl-methyloxycarbonyl)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}~ acetyl]-N2- (3-pyridyl-methyloxycarbonyl)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}~ acetyl]-N2- (4-pyridyl-methyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}~ acetyl]-N2- (4-butyloxyphenylsulfonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R,S)-yl}~ acetyl]-N2- (2-thienylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (3-methylphenylsulfonyl)-2,3-(R,S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (3-methylphenylsulfonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S ) -yl} - acetyl]-N2- (3-methylphenylsulfonyl)-2,3-(R)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R)-yl}- acetyl]-N2- (3-methylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; _ N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (S) -yl} - acetyl]-N2- (3-methylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (S) -yl} - acetyl]-N2- (3-methylphenylsulfonyl)-2,3-(R)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R) -yl} ~ acetyl]-N2- (3-methylphenylsulfonyl)-2,3-(R)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S ) -yl} - acetyl]-N2-(4-iodophenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (3-trifluoromethylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl) - acetyl]-N2- (3-chlorophenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(3-2-methoxycarbonylphenylsulfonyl) -2,3- (S)-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl } ~ acetyl]-N2- (2,4,6-trimethylphenylsulfonyl) -2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinopheny1)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (2-chlorophenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} - acetyl]-N2- (4-trifluoromethylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S} -yl} ~ acetyl]-N2-(2-trifluoromethylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(2-fluorophenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5(i?,S, -yl¬ acetyl]-N2- (4-fluorophenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (4-methoxyphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S} -yl} - acetyl]-N2- (2,3,5,6-tetramethylphenylsulfonyl)-2,3- (S)-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (4-cyanophenylsulfonyl)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S)-yl}- acetyl]-N2-(4-chlorophenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl ¬ acetyl]-N2- (4-propylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S)-yl}- acetyl]-N2- (2-phenylethylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (4-isopropylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3- (4-formamidinopheny1)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (3-phenylpropylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3—(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(3-pyridylsulfonyl)-2,3- (S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(phenylaminosulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3- (4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(benzylaminosulfonyl)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl } - acetyl]-N2- (dimethylaminosulfonyl)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(2-fluoro-4-formamidinophenyl)-isoxazolin-5 (R, S) - yl)-acetyl] -N2- (3-methylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3- (2-formamidino-5-pyridinyl) -isoxazolin-5 (R, S) ~ yl}-acetyl]-N2-(n-butyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(2-formamidino-5-pyridinyl)-isoxazolin-5 (R, S) - yl}-acetyl] -N2-(3-methylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(3-formamidino-6-pyridinyl) -isoxazolin-5 (R, S) - yl}-acetyl]-N2-(n-butyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 - [ 2-{3-(3-formamidino-6-pyridinyl) -isoxazolin-5 (R, S) - yl}-acetyl]-N2-(3-methylphenylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S)-yl}- acetyl]-N2-(phenylaminocarbonyl)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3- (4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (4-fluorophenylaminocarbonyl)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3- (4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (1-naphthylaminocarbonyl) -2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} - acetyl]-N2- (benzylaminocarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (3-bromo-2-thienylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S} -yl} ~ acetyl]-N2- (3-methy1-2-benzothienylsulfonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl } ~ acetyl]-N2-(isobutyloxycarbonyl)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R) -yl} - acety1]-N2-(isobutyloxycarbonyl)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (S) -yl} - acetyl]-N2-(isobutyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2- (2-cyclopropylethoxycarbonyl)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (R) -yl} - acety1]-N2- (2-cyclopropylethoxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5 (S) -yl} - acetyl]-N2- (2-cyclopropylethoxycarbonyl)-2,3-(S) - diaminopropanoic acid; N 3 -[2-{3-(4-guanidinophenyl)-isoxazolin-5 (R, S) -yl} ~ acetyl]-N2-(n-butyloxycarbonyl)-2,3-(S)- diaminopropanoic acid; N 3 -[2-{3-(4-guanidinopheny1)-isoxazolin-5 (R) -yl }-acetyl]- N2-(n-butyloxycarbonyl) -2,3-(S)-diaminopropanoic acid; N 3 -[2-{3- (4-guanidinophenyl)-isoxazolin-5 (R) -yl }-acetyl]- N2-(3-methylphenylsulfonyl)-2,3-(S)-diaminopropanoic acid; N 3 -[2-{5-(4-formamidinophenyl)-isoxazolin-3 (R, S) -yl} ~ acetyl]-N2-(n-butyloxycarbonyl)-2,3-(S)- diaminopropanoic acid. 15. A prodrug ester of a compound of Claim 14, said ester being selected from the group consisting of: methyl- ethyl; isopropyl; methylcarbonyloxymethyl-; ethylcarbonyloxymethyl-; t-butylcarbonyloxymethyl-; cyclohexylcarbonyloxymethyl-; 1-(methylcarbonyloxy)ethyl-; 1-(ethylcarbonyloxy)ethyl-; 1-(t-butylcarbonyloxy)ethyl-; 1-(cyclohexylcarbonyloxy)ethyl-; i-propyloxycarbonyloxymethyl-; cyclohexylcarbonyloxymethyl-; t-butyloxycarbonyloxymethyl-; 1-(i-propyloxycarbonyloxy)ethyl-; 1-(cyclohexyloxycarbonyloxy)ethyl-; 1-(t-butyloxycarbonyloxy)ethyl-; dimethylaminoethyl-; diethylaminoethyl-; (5-methyl-l,3-dioxacyclopenten-2-on-4-yl)methyl-; (5- (t-butyl)-1,3-dioxacyclopenten-2-on-4-yl)methyl-; (1,3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methyl-; 1-(2-(2-methoxypropyl)carbonyloxy)ethyl-. 16. A compound of Formula Id: or a pharmaceutically acceptable salt form thereof wherein: R 1 is selected from is selected from R 2 (R 3 )N-, R 2 (R 3 )N(R 2 N=)C-, R 2 (R 3 )N(R 2 N=)CN(R 2 )-, R 2 (R 3 )N(CH2) q Z-, R 2 (R 3 )N(R 2 N=)C(CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)CN(R 2 ) (CH 2 ) q Z-, piperazinyl- (CH2) q Z-, R 2 (R 3 )NC (0) -, R 2 {R 5 0)N(R 2 N=)_C-, R 2 (R 3 )N(R 5 ON=)C-, Z is selected from a bond, 0, S, S(=0), or S(=0) 2 ; R 2 and R 3 are independently selected from: H; Ci-Cio alkyl; C 3 -C alkenyl; C 3 -C 11 cycloalkyl; C 4 -C 11 cycloalkylalkyl; Cg-Cio aryl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(G) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; , C7-C1 1 arylalkyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0) m CI-Ϊ3, -N(CH 3 )2 C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 2 -C 7 alkylcarbonyl; C 7 -C 11 arylcarbonyl optionally- substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(05π ι CH 3 , -N(CH 3 ) , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C1-C 1 0 alkoxycarbonyl; C 4 -C 11 cycloalkoxycarbonyl; C7-C 11 bicycloalkoxycarbonyl; C 7 - C1 1 aryloxycarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Cj-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0)j n CH 3 , -N(CH 3 ) 2 , C1-C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; aryl (C1-C 1 0 alkoxy) carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Cχ-Cg alkoxy, Ci-Cg alkyl, CF3, S{0) n ,CH3, -N(CH 3 ) 2 , C 1 -C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; Ci-Cg alkylcarbonyloxy(C 1 -C4 alkoxy)carbonyl; Cg-Cio arylcarbonyloxy(C 1 -C4 alkoxy)carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF3, S ( 0 ) m CH3, -N ( CH 3 )2/ C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C4-C11 cycloalkylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl; heteroaryl optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF3, S(0) nι CH 3 , -N(CH 3 )2. C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; or heteroaryl (C 1 -C5}alkyl where the heteroaryl group is optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0)a,CH3, -N(CH 3 ) 2 , C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; provided that only one of R 2 and R 3 may be hydroxy; U is selected from: a single bond, C 1 -C 7 alkylene, C2-C7 alkenylene, C 2 -C 7 alkynylene, arylene substituted with 0-3 R 6a , , or pyridylene substituted with 0-3 R 6a ; V is selected from: a single bond; C 1 -C 7 alkylene substituted with 0-6 R 6 or R 7 ; C 2 -C 7 alkenylene substituted with 0-4 R 6 or R 7 ; C 2 -C 7 alkynylene substituted with 0-4 R 6 or R 7 ; phenylene substituted with 0-4 R 6 or R 7 ; pyridylene substituted with 0-3 R 6 or R 7 ; pyridazinylene substituted with 0-3 R 6 or R 7 ; X is selected from: a single bond; -(CH 2 ) n C(=0)N(R 12 )-; C 1 -C 7 alkylene substituted with 0-6 R 4 , R 8 or R 15 ; C 2 -C 7 alkenylene substituted with 0-4 R 4 , R 8 or R 15 ; C 2 -C 7 alkynylene substituted with 0-4 R 4 , R 8 or R 15 ; Y is selected from: hydroxy, Ci to Cio alkyloxy, C 3 to Cn eyeloalkyloxy, Cg to Cio aryloxy, C7 to Cn aralkyloxy, C3 to Cio alkylcarbonyloxyalkyloxy, C 3 .to Cio alkoxycarbonyloxyalkyloxy, C 2 to Cio alkoxycarbonylalkyloxy, C5 to Cio eyeloalkylcarbonyloxyalkyloxy, C 5 to Cio eyeloalkoxycarbonyloxyalkyloxy, C 5 to Cio eyeloalkoxycarbonylalkyloxy, C 7 to Cn aryloxycarbonylalkyloxy, Cs to C12 aryloxycarbonyloxyalkyloxy, Cs to C1 2 arylcarbonyloxyalkyloxy, C5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C5 to Cio (5-alkyl-l,3-dioxa-cyclopenten-2-one- y1)methyloxy, Cio to C 14 (5-aryl-l,3-dioxa-cyclopenten-2-one- yl)methyloxy; (R 2 ) (R 3 )N-(Cι-Cιo alkoxy)-; R 14 and W are attached to the same carbon and taken together to form a spiro-fused, 5-7 membered ring structure of the formula: D, E, F and G are each independently selected from: C ( R 6a) 2 ; carbonyl; a heteroatom moiety selected from N, N(R 12 ), O, provided that no more than 2 of D, E, F and G are N, N(R 12 ), 0, S, or C (=0) ; alternatively, the bond between D and E, E and F, or F and G in such spiro-fused ring may be a carbon-nitrogen double bond or a carbon-carbon double bond; R 4 is selected from H, Ci-Cio alkyl, hydroxy, Ci-Cio alkoxy, nitro, Ci-Cio alkylcarbonyl, or -N(R 12 )R 13 ; R 6 and R 7 are each independently selected from H, Ci-Cio alkyl, hydroxy, Ci-Cio alkoxy, nitro, Ci-Cio alkylcarbonyl, -N(R 12 )R 13 , cyano, halo, CF 3 , CHO, C0 2 R 5a , C(=0)R 5 , CONHR 5a , CON(R 12 ) 2 , OC(=0)R 5a , OC(=0)OR 5a , OR 5a , OC(=0)N(R 12 ) 2 , OCH 2 C0 R 5a , C0 2 CH 2 C0 2 R 5a , N(R 12 ) 2 , N0 2 , NR 12 C (=0)R 5a , NR 12 C(=0)0R 5a , NR 12 C(=0)N(R 12 ) 2 , NR 12 Sθ2N(R 12 ) 2 , NR 12 S02R 5a , S(0) p R 5a , S0 2 N(R 12 ) 2 , C 2 to Cg alkenyl, C 3 to Cn cycloalkyl, C4 to Cn cycloalkylmethyl; Cg to Cio aryl optionally substituted with 1-3 groups selected from halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0)mMe, or -NMe 2 ; C 7 to Cn arylalkyl, said aryl being optionally substituted with 1-3 groups selected from halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF3, S(0)mMe, or -NMe2; methylenedioxy when R 6 is a substituent on aryl; R 6a is selected from C 1 -C4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , NO2, or NR 12 R 13 ; R 8 is selected from: H; R 6 ; C 1 -C10 alkyl, substituted with 0-8 R 6 ; C 2 -C10 alkenyl, substituted with 0-6 R 6 ; C 2 -C10 alkynyl, substituted with 0-6 R 6 ; C 3 -C 8 cycloalkyl, substituted with 0-6 R 6 ; C 5 -Cg cycloalkenyl, substituted with 0-5 R 6 ; aryl, substituted with 0-5 R 6 ; 5-6 membered heterocyclic ring containing 1-2 N, 0, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-5 R 6 ; R 12 and R 13 are independently H, C 1 -C10 alkyl, C 1 -C10 alkoxycarbonyl, C 1 -C 10 alkylcarbonyl, C 1 -C 10 alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, arylsulfonyl, aryl, C2-Cg alkenyl, C 3 -C 11 cycloalkyl, C4-C11 cycloalkylalkyl, C7-C11 arylalkyl, C 2 -C 7 alkylcarbonyl, C 7 -C 1 1 arylcarbonyl, C2-C10 alkoxycarbonyl, C4-C 1 1 cycloalkoxycarbonyl, C 7 -C 11 bicycloalkoxycarbonyl, C7-C11 aryloxycarbonyl, heteroarylcarbonyl, he eroarylsulfonyl, heteroarylalkylcarbony1 or aryl(Cι-Cιo alkoxy) carbonyl, wherein said aryl groups and heteroaryl groups are optionally substituted with 0-3 substituents selected from: C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , and NO 2 ; R 5 and R 5a are selected independently from H, Ci to Cs alkyl, C2 to Cg alkenyl, C3 to Cn cycloalkyl, C 4 to Cn cycloalkylmethyl, Cg to Cio aryl, C 7 to Cn arylalkyl, or C 1 -C1 0 alkyl substituted with 0-8 R 4 ; R 15 is selected from: H; R 6 ; C1-C 1 0 alkyl, substituted with 0-8 R 6 ; C2-C1 0 alkenyl, substituted with 0-6 R 6 ; C1-C 10 alkoxy, substituted with 0-6 R 6 ; aryl, substituted with 0-5 R 6 ; 5-6 membered heterocyclic ring containing 1-2 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-5 R 6 ; C 1 -C 10 alkoxycarbonyl substituted with 0-8 R 6 ; CO 2 R 5 ; or -C(=0)N(R 12 )R 13 ; provided that n, p, q and r are chosen such that the number of atoms between R 1 and Y is in the range of 8-17. 17. A compound of Claim 16 of Formula III: wherein: R 1 is selected from R 2 HN-, H 2 N(R 2 N=)C-, H 2 N(R 2 N=)CNH-, R 2 HN(CH 2 )qO-, H 2 (R N=)CNH(CH 2 ) q O-, piperazinyl- (CH 2 ) q O-, R 2 (R 3 )NC (O) -, R 2 (R 5 0)N(R 2 N=)C-, R 2 (R 3 )N(R 5 ON=)C-, R 2 and R 3 are selected from H; Ci-Cg alkyl; C7-C1 1 arylalkyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF3, S(G) m CH 3 , -N(CH 3 )2, C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; aryl(Cι-Cιo alkoxy)carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl,-CF 3 , S(0 m CH 3 , -N(CH3)2. C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; heteroaryl (Cχ~Cs)alkyl wherein the heteroaryl group is optionally substituted with 0-2 groups selected from hydroxy, halogen, C'ι-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0)π ι CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; or C 1 -C 10 alkoxycarbonyl; R 4 is selected from H, C1-C10 alkyl, hydroxy, C1-C 1 0 alkoxy, nitro, C1-C 10 alkylcarbonyl, or -N(R 1 )R 13 ; V is selected from: a single bond; C 1 -C 7 alkylene substituted with 0-6 R 6 or R 7 ; C 2 -C 7 alkenylene substituted with 0-4 R 6 or R 7 ; C 2 -C 7 alkynylene substituted with 0-4 R 6 or R 7 ; phenylene substituted with 0-3 R 6 or R 7 ; pyridylene substituted with 0-3 R 6 or R 7 ; pyridazinylene substituted with 0-3 R 6 or R 7 ; X is selected from - (CH2) n C(=0)N(R 12 ) -, C 1 -C 7 alkylene substituted with 0-1 R 4 , C2-C7 alkenylene, or C 2 -C 7 alkynylene; Y is selected from: hydroxy, Ci to Cio alkyloxy, C3 to Cn cycloalkyloxy, Cζ to Cio aryloxy, C7 to Cn aralkyloxy, C3 to Cio alkylcarbonyloxyalkyloxy, C3 to Cio alkoxycarbonyloxyalkyloxy, C2 to Cio alkoxycarbonylalkyloxy, C5 to Cio cycloalkylcarbonyloxyalkyloxy, C5 to Cio eyeloalkoxycarbonyloxyalkyloxy, C5 to Cio cycloalkoxycarbonylalkyloxy, C7 to Cn aryloxycarbonylalkyloxy, C8 to C12 aryloxycarbonyloxyalkyloxy, C8 to C12 arylcarbonyloxyalkyloxy, C5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C5 to Cio (5-alkyl-l,3-dioxa-cyclopenten-2-one- y1)methyloxy, or Cio to C14 (5-aryl-l,3-dioxa-cyclopenten-2-one- yDmethyloxy; Z is selected from O or CH 2 ; D, E, F and G are each independently selected from: CH 2 ; carbonyl; a heteroatom moiety selected from N, NH, O, provided that no more than 2 of D, E, F and G are N, NH, 0 or S; alternatively, the bond between D and E, E and F, or F and G in such spiro-fused ring may be a carbon-nitrogen double bond or a carbon-carbon double bond; R 6 and R 7 are each independently selected from H, C 1 -C 1 0 alkyl, hydroxy, C 1 -C 1 0 alkoxy, nitro, C 1 -C 1 0 alkylcarbonyl, -N(R 12 )R 13 , cyano, or halo; R 12 and R 13 are each independently selected from H, Ci-Cio alkyl, Ci-Cio alkoxycarbonyl, Ci-Cio alkylcarbonyl, Ci-Cio alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, arylsulfonyl, heteroarylsul onyl, heteroarylcarbonyl, heteroaryalkylcarbonyl or aryl; n is 0-4 p is 1-3 q is 1-7 r is 0-3; provided that n, p, q and r are chosen such that the number of atoms between R 1 and Y is in the range of 8-17. 18. A compound of Claim 17 wherein: R 1 is R 2 NHC(=NR 2 )- and V is phenyl or pyridyl or R 1 is and V is a single bond; n is 1 or 2; X is C 1 -C 4 alkylene substituted with 0-1 R 4 ; Y is selected from: hydroxy; Ci to Cio alkoxy; methylcarbonyloxymethoxy-; ethylcarbonyloxymethoxy-; t-butylcarbonyloxymethoxy-; cyclohexylcarbonyloxymethoxy-; 1- (methylcarbonyloxy)ethoxy-; 1-(ethylcarbonyloxy)ethoxy-; 1- (t-butylcarbonyloxy)ethoxy-; 1-(cyclohexylcarbonyloxy)ethoxy-; i-propyloxycarbonyloxymethoxy-; t-butyloxycarbonyloxymethoxy-; 1-(i-propyloxycarbonyloxy)ethoxy-; 1-(cyclohexyloxycarbonyloxy)ethoxy-; 1- (t-butyloxycarbonyloxy)ethoxy-; dimethylaminoethoxy-; diethylaminoethoxy-; (5-methyl-l,3-dioxacyclopenten-2-on-4-yl)methoxy-; (5-(t-butyl)-1,3-dioxacyclopenten-2-on-4-yl)methoxy-; (1,3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methoxy-; 1-(2-(2-methoxypropyl)carbonyloxy)ethoxy-; R 12 and R 13 are each independently selected from H, Ci-Cg alkyl, C 1 -C 4 alkoxycarbonyl, C 1 -C 4 alkylcarbonyl, Ci- C 4 alkylsulfonyl, aryl(Cι-C 4 alkyl)sulfonyl, heteroarylsulfonyl, arylsulfonyl, heteroarylcarbonyl, heteroaryalkylcarbonyl or aryl; and R 13 is H. 19. A compound of Claim 16, or pharmaceutically acceptable salt forms thereof, selected from: 5 (R, S)-3-(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2,8- diazaspiro[4.4]non-2-ene-7,9-dione; 5 (R, S)-3-(4-amidinophenyl)-8-(3-carboxypropyl)-l-oxa-2,8- diazaspiro[4.4]non-2-ene-7,9-dione; 5 (R, S)-3-(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2,8- diazaspiro[4.4]non-2-ene-5-one; 5 (R, S)-3-(4-amidinophenyl)-8- (3-carboxypropyl)-l-oxa-2,8- diazaspiro[4.4]non-2-ene-5-one; 5 (R, S)-3- (4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2- azaspiro[4.4]nona-2,8-diene-5-one; 5 (R, S)-3-(4-amidinophenyl)-8- (3-carboxypropyl)-l-oxa-2- azaspiro[4.4]nona-2,8-diene-5-one; 5 (R, S) -3 -(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2,8- diazaspiro[4.4]dec-2-ene-7,9-dione; 5 (R, S)-3-(4-amidinophenyl)-8- (3-carboxypropyl)-l-oxa-2,8- diazaspiro[4.4]dec-2-ene-7,9-dione; 5 (R, S)-3-(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2,8- diazaspiro[4.4]dec-2-ene-5-one; 5 (R, S)-3-(4-amidinopheny1)-8- (3-carboxypropyl)-l-oxa-2,8- diazaspiro[4.4]dec-2-ene-5-one; 5 (R, S)-3-(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2- azaspiro[4.4]deca-2,8-diene-5-one; 5 (R, S)-3-(4-amidinophenyl)-8- (3-carboxypropyl)-l-oxa-2- azaspiro[4.4]deca-2,8-diene-5-one; 5 (R, S)-3-(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2,8- diazaspiro[4.4]undec-2-ene-7,9-dione; 5 (R, S)-3-(4-amidinophenyl)-8- (3-carboxypropyl)-l-oxa-2,8- diazaspiro[4.4]undec-2-ene-7,9-dione; 5 (R, S)-3-(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2,8- diazaspiro[4.4]undec-2-ene-5-one; 5 (R, S) -3 -(4-amidinophenyl)-8- (3-carboxypropyl)-l-oxa-2,8- diazaspiro[4.4]undec-2-ene-5-one; 5 (R, S)-3-(4-amidinophenyl)-8- (2-carboxyethyl)-l-oxa-2- azaspiro[4.4]undeca-2,8-diene-5-one; 5 (R, S)-3-(4-amidinophenyl)-8- (3-carboxypropyl)-l-oxa-2- azaspiro[4.4]undeca-2,8-diene-5-one; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(2-carboxyethyl)-1- oxa-2,8-diazaspiro[4.4]non-2-ene-7,9-dione; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(3-carboxypropyl)-1- oxa-2,8-diazaspiro[4.4]non-2-ene-7,9-dione; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(2-carboxyethyl)-1- oxa-2,8-diazaspiro[4.4]non-2-ene-5-one; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(3-carboxypropyl) -1- oxa-2,8-diazaspiro[4.4]non-2-ene-5-one; 5 (R, S)-3-[2- (piperidin-4-yl)ethyl]-8-(2-carboxyethyl)-1- oxa-2-azaspiro[4.4]nona-2,8-diene-5-one; 5 (R, S)-3-[2- (piperidin-4-yl)ethyl]-8-(3-carboxypropyl) -1- oxa-2-azaspiro[4.4]nona-2,8-diene-5-one; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(2-carboxyethyl)-1- oxa-2,8-diazaspiro[4.4]dec-2-ene-7,9-dione; 5 (R, S)-3-[2- (piperidin-4-yl)ethyl]-8-(3-carboxypropyl)-1- oxa-2,8-diazaspiro[4.4]dec-2-ene-5,7-dione; 5 (R, S)-3-[2- (piperidin-4-yl)ethyl]-8-(2-carboxyethyl)-1- oxa-2,8-diazaspiro[4.4]dec-2-ene-5-one; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(3-carboxypropyl)-1- oxa-2,8-diazaspiro[4.4]dec-2-ene-5-one; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(2-carboxyethyl)-1- oxa-2-azaspiro[4.4]deca-2,8-diene-5-one; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(3-carboxypropyl) -1- oxa-2-azaspiro[4.4]deca-2,8-diene-5-one; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(2-carboxyethyl)-1- oxa-2,8-diazaspiro[4.4]undec-2-ene-7,9-dione; 5 (R, S) -3-[2-(piperidin-4-yl)ethyl]-8-(3-carboxypropyl) -1- oxa-2,8-diazaspiro[4.4]undec-2-ene-7,9-dione; 5 (R, S)-3-[2- (piperidin-4-yl)ethyl]-8-(2-carboxyethyl)-1- oxa-2,8-diazaspiro[4.4]undec-2-ene-5-one; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8- (3-carboxypropyl) -1- oxa-2,8-diazaspiro[4.4]undec-2-ene-5-one; 5 (R, S)-3-[2-(piperidin-4-yl)ethyl]-8-(2-carboxyethyl)-1- oxa-2-azaspiro[4.4]undeca-2,8-diene-5-one; 5(i?,≤')-3-[2-(piperidin-4-yl)ethyl]-8-(3-carboxypropyl)-l- oxa-2-azaspiro[4.4]undeca-2,8-diene-5-one; 5(R,S)-3-(4-amidinophenyl)-8-[2-(benzyloxycarbonylamino)- 2-carboxyethyl]-l-oxa-2,8-diazaspiro[4.5]dec-2-ene. 20. A compound of Formula I: or pharmaceutically acceptable salt form thereof, wherein: b is a carbon-carbon single bond or double bond; R 1 is selected from: R 2 (R 3 )N(CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)C (CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)CN(R 2 ) (CH2) q Z-, piperazinyl- (CH2) q Z- or Z is selected from 0, S, S(=0), S(=0)2; R 2 and R 3 are independently selected from: H, C 1 -C 10 alkyl, C 2 -Cg alkenyl, C 3 -C1 1 cycloalkyl, C 4 -C 11 cycloalkylalkyl, Cg-Cio aryl, C7-C1 1 ary l a lk y l , C 2 -C7 alkylcarbonyl, C 7 -C 11 arylcarbonyl, C 2 -C 10 alkoxycarbonyl, C4-C 11 cycloalkoxycarbonyl, C 7 -C1 1 bicycloalkoxycarbonyl, C 7 -C11 aryloxycarbonyl, or aryl(Cι-Cιo alkoxy) carbonyl, Ci-Cg alkylcarbonyloxy(C1-C4 alkoxy) carbonyl, Cg-Cio arylcarbonyloxy(C1-C4 alkoxy)carbonyl, C 4 -C 11 cycloalkylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl; U is optionally present and is selected from C 1 -C 7 alkylene, C2-C 7 alkenylene, C2-C7 alkynylene, arylene, or pyridylene; V is selected from: a single bond; C 1 -C7 alkylene substituted with 0-6 R 6 or R 7 ; C2-C 7 alkenylene substituted with 0-4 R 6 or R 7 ; C2-C 7 alkynylene substituted with 0-4 R 6 or R 7 ; phenylene substituted with 0-4 R 6 or R 7 ; pyridylene substituted with 0-3 R 6 or R 7 ; pyridazinylene substituted with 0-3 R 6 or R 7 ; is -(aryl)-Z 1 -, wherein said aryl is substituted with 0-6 R β or R 7 ; Z 1 is selected from a single bond, -CH 2 -, 0 or S; X is selected from: a single bond; C 1 -C 7 alkylene substituted with 0-6 R 4 , R 8 or R 15 ; C2-C7 alkenylene substituted with 0-4 R 4 , R 8 or R 15 ; C2-C7 alkynylene substituted with 0-4 R 4 , R 8 or R 15 ; Y is selected from hydroxy, Ci to Cio alkyloxy, C 3 to Cn cycloalkyloxy, Cg to Cio aryloxy, C7 to Cn aralkyloxy, C3 to Cio alkylcarbonyloxyalkyloxy, C3 to Cio alkoxycarbonyloxyalkyloxy, C2 to Cio alkoxycarbonylalkyloxy, C5 to Cio cycloalkylcarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonylalkyloxy, C7 to Cn aryloxycarbonylalkyloxy, Cs to C 12 aryloxycarbonyloxyalkyloxy, Cs to C 1 2 arylcarbonyloxyalkyloxy, C5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C5 to Cio (5-alky1- 1,3-dioxa-cyclopenten-2-one-yl)methyloxy, Cio to C 14 (5-aryl-l,3-dioxa-cyclopenten-2-one-yl)methyloxy; (R 2 ) (R 3 )N-(Cι-Cιo alkoxy)-; R 4 is selected from H, C 1 -C 1 0 alkyl, hydroxy, C1-C 10 alkoxy, nitro, C 1 -C 10 alkylcarbonyl, or -N(R 12 )R 13 ; R 6 and R 7 are each independently selected from H, C 1 -C1 0 alkyl, hydroxy, C 1 -C10 alkoxy, nitro, C1-C 10 alkylcarbonyl, -N(R 12 )R 13 , cyano, halo, CF 3 , CHO, C0 2 R 5a , C(=0)R 5a , CONHR 5 , C0N(R 12 ) 2 , OC(=0)R 5a , OC(=0)OR 5a , OR 5 , OC(=0)N(R 12 )2, OCH 2 C02R 5a , Cθ2CH 2 Cθ2R 5a , N(R 12 )2, O2, NR 12 C (=0)R 5a , NR 12 C(=0)OR 5 , NR 12 C(=0)N(R 12 )2, NR 12 S02N(R 12 )2, NR 12 S02R 5a , S(0) p R 5 , S0 2 N(R 12 )2, C2 to Cg alkenyl, C 3 to Cn cycloalkyl, C 4 to Cn cycloalkylmethyl; Cg to Cio aryl optionally substituted with halogen, alkoxy, alkyl, -CF 3 , S(0)mMe, or - e2; or C7 to Cn arylalkyl said aryl being optionally substituted with halogen, alkoxy, alkyl, -CF 3 , S(0)mMe, or -NMe 2 ; R 8 is selected from: H; R 6 ; C1-C10 alkyl, substituted with 0-8 R 6 ; C 2 -C 10 alkenyl, substituted with 0-6 R 6 ; C2-C1 0 alkynyl, substituted with 0-6 R 6 ; C 3 -C δ cycloalkyl, substituted with 0-6 R 6 ; C 5 -Cg cycloalkenyl, substituted with 0-5 R 6 ; aryl, substituted with 0-5 R 6 ; 5-6 membered heterocyclic ring containing 1-2 N, 0, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-5 R 6 ; R 12 and R 13 are independently H, C 1 -C 10 alkyl, C 1 -C 10 alkoxycarbonyl, C 1 -C 1 0 alkylcarbonyl, C 1 -C 10 alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, neteroaryisuifonyl, arylsulfonyl, aryl, C 2 -Cg alkenyl, C 3 -C 11 cycloalkyl, C 4 -C 11 cycloalkylalkyl, C7-C11 ar yialkyl, C 2 -C 7 alkylcarbonyl, C7-C11 arylcarbonyl, C2-C1 0 alkoxycarbonyl, C4-C 11 cycloalkoxycarbonyl, C 7 -C 11 bicycloalkoxycarbonyl, C 7 - C 11 aryloxycarbonyl, heteroarylcarbonyl, heteroarylalkylcarbonyl or aryl(Cι-Cιo alkoxy)carbonyl; R 14 is selected from H, Ci-Cio alkyl, C 2 -C 1 0 alkenyl, C2- C 1 0 alkynyl, C 1 -C 10 alkoxy, aryl, heteroaryl or C 1 -C 1 0 alkoxycarbonyl, CO 2 R 5 or -C(=0)N(R 12 )R 13 ; R 5 and R 5 are selected independently from H, Ci to Cs alkyl, C 2 to Cg alkenyl, C 3 to Cn cycloalkyl, C 4 to Cn cycloalkylmethyl, Cg to Cio aryl, C 7 to Cn arylalkyl, or C 1 -C 10 alkyl substituted with 0-8 R 4 ; R 15 is selected from: H; R 6 ; C 1 -C1 0 alkyl, substituted with 0-8 R 6 ; C 2 -C 1 0 alkenyl, substituted with 0-6 R 6 ; C 1 -C 1 0 alkoxy, substituted with 0-6 R 6 ; aryl, substituted with 0-5 R 6 ; 5-6 membered heterocyclic ring containing 1-2 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-5 R 6 ; C 1 -C 10 alkoxycarbonyl substituted with 0-8 R 6 ; CO2R 5 ; or -C(=0)N(R 12 )R 13 ; provided that n, q, and r are chosen such that the number of atoms between R 1 and Y is about 8-17. 21. A compound of Claim 20 of Formula IV: wherein: b is a carbon-carbon single bond or double bond; R 1 is selected from R 2 HN(CH 2 ) q O-, R 2 HN(R 2 N=C)NH(CH 2 ) q O-, piperazinyl-(CH 2 ) q 0-, or Z is 0; R 2 is selected from H, aryl(Ci-Cio)alkoxycarbonyl, Ci-Cio alkoxycarbonyl; V is selected from: a single bond; Ci-C7 alkylene substituted with 0-6 R 6 or R 7 ; C 2 -C 7 alkenylene substituted with 0-4 R 6 or R 7 ; C 2 -C 7 alkynylene substituted with 0-4 R 6 or R 7 ; phenylene substituted with 0-3 R 6 or R 7 ; pyridylene substituted with 0-3 R 6 or R 7 ; pyridazinylene substituted with 0-3 R 6 or R 7 ; Z 1 is selected from a single bond, O or S; X is selected from: a single bond; C 1 -C 7 alkylene substituted with 0-4 R 4 , R 8 or R 15 ; C 2 -C 7 alkenylene substituted with 0-3 R 4 , R 8 or R 15 ; C 2 -C 7 alkynylene substituted with 0-3 R 4 , R 8 or R 15 ; Y selected from hydroxy, Ci to Cio alkyloxy, C 3 to Cn cycloalkyloxy, Cg to Cio aryloxy, C7 to Cn aralkyloxy, C3 to Cio alkylcarbonyloxyalkyloxy, C 3 to Cio alkoxycarbonyloxyalkyloxy, C 2 to Cio alkoxycarbonylalkyloxy, C 5 to Cio cycloalkylcarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonylalkyloxy, C 7 to Cn aryloxycarbonylalkyloxy, Cs to C 12 aryloxycarbonyloxyalkyloxy, Cs to C12 arylcarbonyloxyalkyloxy, C 5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C 5 to Cio (5-alkyl- 1,3-dioxa-cyclopenten-2-one-yl)methyloxy, or Cio to C14 (5-aryl-l,3-dioxa-cyclopenten-2-one-yl)methyloxy; R 4 is selected from H, C1-C 10 alkyl, hydroxy, C1-C 1 0 alkoxy, nitro, C1-C10 alkylcarbonyl, or -N(R 12 )R 13 ; R 6 and R 7 are selected from H, C 1 -C10 alkyl, hydroxy, C 1 -C10 alkoxy, nitro, C 1 -C 1 0 alkylcarbonyl, -N(R 12 )R 13 , cyano, or halo; R 8 is selected from H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 3 - Cβ cycloalkyl, Cs-Cg cycloalkenyl, aryl, 5-6 membered heterocyclic ring containing 1-2 N, 0, or S, where said heterocyclic ring may be saturated, partially saturated, or fully unsaturated; R 12 and R 13 are independently selected from H, C 1 -C 10 alkyl, C 1 -C 1 0 alkoxycarbonyl, C1-C 1 0 alkylcarbonyl, C 1 -C 1 0 alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, arylsulfonyl, heteroarylcarbonyl, heteroarylsulfonyl, heteroarylalkylcarbonyl or aryl; R 14 is selected from H, C 1 -C 1 0 alkyl, C2-C10 alkenyl, C2- Cio alkynyl, C 1 -C 10 alkoxy, aryl, heteroaryl or C 1 -C10 alkoxycarbonyl, CO2R 5 or -C (=0)N(R 12 )R 13 ; R 5 is selected from H or C 1 -C 10 alkyl substituted with 0-6 R 4 ; n is 0-4; q is 2-7; provided that n and q are chosen such that the number of atoms between R 1 and Y is in the range of 8-17. 22. A compound of Claim 21 wherein: R 1 is R 2 HN(CH 2 ) q O- or V is Cι-C 3 alkylene; Z 1 is a single bond or O; X is Cι~C 3 alkylene substituted with 0-1 R 4 ; Y is selected from: hydrox ; Ci to Cio alkoxy; methylcarbonyloxymethoxy-; ethylcarbonyloxymethoxy-; t-butylcarbonyloxymethoxy-; cyclohexylcarbonyloxymethoxy-; 1-(methylcarbonyloxy)ethoxy-; 1-(ethylcarbonyloxy)ethoxy-; 1-(t-butylcarbonyloxy)ethoxy-; 1-(eyelohexylcarbonyloxy)ethoxy-; i-propyloxycarbonyloxymethoxy-; t-butyloxycarbonyloxymethoxy-; 1-(i-propyloxycarbonyloxy)ethoxy-; 1-(cyclohexyloxycarbonyloxy)ethoxy-; 1-(t-butyloxycarbonyloxy)ethoxy-; dimethylaminoethoxy-; diethylaminoethoxy-; (5-methyl-l,3-dioxacyclopenten-2-on-4-yl)methoxy-; (5-(t-butyl)-1,3-dioxacyclopenten-2-on-4-yl)methoxy-; (l,3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methoxy-; 1-(2- (2-methoxypropyl)carbonyloxy)ethoxy-; R 12 and R 13 are independently selected from H, Ci-Cg alkyl, C 1 -C 4 alkoxycarbonyl, C 1 -C 4 alkylcarbonyl, Ci-Cg alkylsulfonyl, aryl(Cι-C 4 alkyl)sulfonyl, arylsulfonyl, heteroarylcarbonyl, heteroarylsulfonyl, heteroarylalkylcarbonyl or aryl; R 13 is H. 23. A compound of Claim 20, or a pharmaceutically acceptable salt form thereof, selected from: 5 (R, S)-4-[3-(piperidin-4-yl)oxymethylisoxazolin-5-yl]hy- drocinnamic acid; 5 (R, S)-4-[3-(2-aminoethoxymethyl)isoxazolin-5-yl]hydro- cinnamic acid; 5 (R, S)-4-[3-(3-aminopropyloxymethyl)isoxazolin-5-yl]hy- drocinnamic acid; 5 (R, S) -A-[3-(piperidin-4-yl)oxymethylisoxazolin-5- yl]phenoxyacetic acid; 5 (R, S)-4-[3-(2-aminoethoxymethyl)isoxazolin-5-yl]phen- oxyacetic acid; 5 (R, S)-4-[3-(3-aminopropyloxymethyl)isoxazolin-5- yl]phenoxyacetic acid. 24. A compound of Formula I: or a pharmaceutically acceptable salt form thereof wherein: b is a carbon-carbon single or double bond; R 1 is selected from R 2a (R 3 )N-, R 2 (R 3 )N(R 2 N=)C-, R 2 (R 3 )N(CH 2 ) q Z-, R 2 (R 3 )N(R 2 N=)C (CH 2 ) q Z-, R 2 (R 3 )NC (O) -, R 2 (R 5 0)N(R 2 N=)C-, R 2 (R 3 ) (R 5 ON=)C- ; Z is selected from a bond, O, S, S(=0), S(=0)2; R 2 and R 3 are independently selected from: H; Ci-Cio alkyl; C3-Cg alkenyl; C3-C11 cycloalkyl; C4-C11 cycloalkylalkyl; Cg-Cio aryl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 )2, C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C7- C11 arylalkyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF3, S(0) ] CH 3 , -N(CH 3 ) , C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C2-C7 alkylcarbonyl; C7-C11 arylcarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF3, 5(0) m CK 3 , -N(CH 3 )2, C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C1-C10 alkoxycarbonyl; C4-C11 cycloalkoxycarbonyl; C7-C11 bicycloalkoxycarbonyl; C7- C11 aryloxycarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0) m CH3, -N(CH 3 )2, C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; aryl (C1-C10 alkoxy) carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Cι~Cg alkyl, CF 3 , S(0) m CH3, -N(CH 3 )2, C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; Ci-Cg alkylcarbonyloxy(C1-C 4 alkoxy) carbonyl; Cg-Cio arylcarbonyloxy(C1-C4 alkoxy)carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF3, S(0> ro CH 3 , -N(CH 3 )2, C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 4 -C11 cycloalkylcarbonyloxy(C 1 -C4 alkoxy)carbonyl; heteroaryl optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF3, S(0) n ιCH 3 , -N(CH 3 )2, C1-C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; or heteroaryl (C 1 -C 5 }alkyl where the heteroaryl group is optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF3, S(0)mCH3, -N(CH 3 )2, C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; provided that only one of R 2 and R 3 may be hydroxy; R 2a is R 2 or R 2 (R 3 )N(R 2 N=)C; U is selected from: a single bond, -(C1-C7 alkyl)-, -(C2-C7 alkenyl)-, -(C2-C7 alkynyl)-, -(aryl)- substituted with 0-3 R 6a , or -(pyridyl)- substituted with 0-3 R 6 ; V is selected from: a single bond; - (C 1 -C 7 alkyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(C2-C 7 alkenyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -{C2-C7 alkynyl)-, substituted with 0-3 groups independently selected from R 6 or R 7 ; -(phenyl)-, substituted with 0-2 groups independently selected from R 6 or R 7 ; -(pyridyl)-, substituted with 0-2 groups independently selected from R 6 or R 7 ; or -(pyridazinyl)-, substituted with 0-2 groups independently selected from R 6 or R 7 ; is selected from: X is selected from: a single bond, -(C(R ) 2 ) n -C(R 4 ) (R 8 )-C(R 4 ) (R 4a )-, with the proviso that when n is 0 or 1, then at least one of R or R 8 is other than H or methyl; Y selected from: hydroxy, Ci to Cio alkyloxy, C 3 to Cn eyeloalkyloxy, Cg to Cio aryloxy, C 7 to Cn aralkyloxy, C 3 to Cio alkylcarbonyloxyalkyloxy, C 3 to Cio alkoxycarbonyloxyalkyloxy, C2 to Cio alkoxycarbonylalkyloxy, C5 to Cio eyeloalkylcarbonyloxyalkyloxy, C5 to Cio cycloalkoxycarbonyloxyalkyloxy, C5 to Cio eyeloalkoxycarbonylalkyloxy, C7 to Cn aryloxycarbonylalkyloxy, Cs to C 1 2 aryloxycarbonyloxyalkyloxy, Cs to C 12 arylcarbonyloxyalkyloxy, C5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C 5 to Cio (5-alkyl-l,3-dioxa-cyclopenten-2-one- yl)methyloxy, _ Cio to C 14 (5-aryl-l,3-dioxa-cyclopenten-2-one- yDmethyloxy, (R 2 ) (R 3 )N-(Cι-Cιo alkoxy)-; Z 1 is -C-, -0-, or -NR 22 -; Z 2 is -0-, or -NR 22 -; R 4 is selected from H, C 1 -C10 alkyl, C 1 -C10 alkylcarbonyl, aryl, arylalkylene cycloalkyl, or cycloalkylalkylene; alternately, two R 4 groups on adjacent carbon atoms may join to form a bond, thereby to form a carbon-carbon double or triple bond between such adjacent carbon atoms; R 4 is selected from H, hydroxy, C 1 -C 10 alkoxy, nitro, N(R 5 )R 5 , -N(R 12 )R 13 , -N(R 16 )R 17 , C 1 -C 10 alkyl substituted with 0-3 R 6 , aryl substituted with 0-3 R 6 , or C 1 -C 1 0 alkylcarbonyl; R b is selected from H, Ci-Cg alkyl, C 2 -Cg alkenyl, C 2 -Cg alkynyl, hydroxy, Ci-Cg alkoxy, Ci-Cg alkylthio, Ci-Cg alkylsulfinyl, Ci-Cg alkylsulfonyl, nitro, Ci-Cg alkylcarbonyl, Cg-Cio aryl, -N(R 12 )R 13 ; halo, CF 3 CN, Ci-Cg alkoxycarbonyl, carboxy, piperidinyl, or pyridyl; R 5 is selected from H, Ci-Cs alkyl, C2~Cg alkenyl, C3-C1 1 cycloalkyl, C 4 -C 1 1 cycloalkylmethyl, Cg-Cio aryl, C 7 - C 11 arylalkyl, or C 1 -C 10 alkyl substituted with 0-2 R 4b ; R 5a is selected from hydrogen, hydroxy, Ci to Cs alkyl, C2 to Cg alkenyl, C 3 to Cn cycloalkyl, C4 to Cn cycloalkylmethyl, Ci-Cg alkoxy, benzyloxy, Cg to Cio aryl, heteroaryl, C 7 to Cn arylalkyl, or C 1 -C10 alkyl substituted with 0-2 R b ; alternately, R 5 and R 5a when both are substituents on the same nitrogen atom (as in -NR 5 R 5a ) can be taken together with the nitrogen atom to which they are " " attached to form 3-azabicyclononyl, 1,2,3,4- tetrahydro-1-quinolinyl, 1,2, 3,4-tetrahydro-2- isoquinolinyl, 1-piperidinyl, 1-morpholinyl, 1- pyrrolidinyl, thiamorpholinyl, thiazolidinyl or 1- piperazinyl, each being optionally substituted with Ci-Cg alkyl, Cg-Cio aryl, heteroaryl, C7-C 1 1 arylalkyl, Ci-Cg alkylcarbonyl, C 3 -C7 cycloalkylcarbonyl, Ci-Cg alkoxycarbonyl, C 7 -C1 1 arylalkoxycarbonyl, Ci-Cg alkylsulfonyl or Cg-Cio arylsulfonyl; R 5b is selected from Ci-Cs alkyl, C2~C alkenyl, C 3 -C 11 cycloalkyl, C 4 -C11 cycloalkylmethyl, Cg-Cio aryl, C 7 - C11 arylalkyl, or C 1 -C10 alkyl substituted with 0-2 R 4b ; R 6 is selected from H, C 1 -C1 0 alkyl, hydroxy, C 1 -C1 0 alkoxy, nitro, C1-C10 alkylcarbonyl, -N(R 12 )R 13 , cyano, halo, CF 3 , CHO, CO 2 R 5 , C (=0)R 5 , CONR 5 R 5a , 0C(=0)R 5a , 0C(=0)0R 5b , OR 5 , OC (=0)NR 5 R 5a , OCH2CO 2 R 5 , CO2CH2CO2R 5 , N0 2 , NR 5a C(=0)R 5 , NR 5a C(=0)OR 5b , NR 5a C(=0)NR 5 R 5a , NR 5 Sθ 2 NR 5 R 5 , NR 5a Sθ 2 R 5 , S(0) p R 5 , S02NR 5 R 5a , C2 to Cg alkenyl, C 3 to Cn cycloalkyl, C4 to Cn cycloalkylmethyl; Cg to Cio aryl optionally substituted with 1-3 groups selected from halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , C7 to Cn arylalkyl, said aryl being optionally substituted with 1-3 groups selected from halogen, C -Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0)mMe, or -NMe 2 ; methylenedioxy when R 6 is a substiuent on aryl; or a 5-6 membered heterocyclic ring containing 1-2 N, O, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 7 ; R 6a is selected from C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , NO 2 , or NR 12 R 13 ; R 7 is selected from H, C 1 -C 10 alkyl, hydroxy, C 1 -C 10 alkoxy, nitro, C 1 -C 10 alkylcarbonyl, -N(R 12 )R 13 , cyano, halo, CF 3 , CHO, CO2R 5 , C(=0)R 5a , CONR 5 R 5a , OC(=0)R 5a , OC(=0)OR 5b , 0R 5a , OC(=0)NR 5 R 5 , OCH 2 CO 2 R 5 , CO2CH2CO2R 5 , NO2, NR 5a C(=0)R 5a , NR 5a C(=0)0R 5b , NR 5a C(=0)NR 5 R 5 , NR 5a S0 2 NR 5 R 5a , NR 5a S02R 5 , S(0)mR 5 , S02NR 5 R 5 , C 2 to Cg alkenyl, C3 to Cn cycloalkyl, C4 to Cn cycloalkylmethyl, Cg to Cio aryl, or C7 to Cn arylalkyl; R 8 is selected from: Rδ ; C2-C 10 alkyl, substituted with 0-3 R 6 ; C2-C 10 alkenyl, substituted with 0-3 R 6 ; C2-C 1 0 alkynyl, substituted with 0-3 R 6 ; C3-C8 cycloalkyl, substituted with 0-3 R 6 ; C5-Cg cycloalkenyl, substituted with 0-3 R 6 ; aryl, substituted with 0-3 R 6 ; 5-6 membered heterocyclic ring containing 1-2 N, 0, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 6 ; R 12 and R 13 are independently H, C 1 -C 10 alkyl, C 1 -C 10 alkoxycarbonyl, C 1 -C 10 alkylcarbonyl, C1-C 10 alkylsulfonyl, aryl(Cι-Cιo alkyl)sulfonyl, heteroarylsulfonyl, arylsulfonyl, aryl, C2-Cg alkenyl, C 3 -C11 cycloalkyl, C 4 -C11 cycloalkylalkyl, C7-C11 arylalkyl, C7-C11 arylcarbonyl, C 4 -C11 cycloalkoxycarbonyl, C 7 -C 11 bicycloalkoxycarbonyl, C 7 - C 11 aryloxycarbonyl, or aryl(Cι-Cιo alkoxy)carbonyl, wherein said aryls are optionally substituted with 0- 3 substituents selected from the group consisting of: C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, CF3, and NO2; R 14 is selected from H, C1-C 1 0 alkyl, C2-C1 0 alkenyl, C2- C10 alkynyl, C 1 -C10 alkoxy, aryl, heteroaryl or C1-C10 alkoxycarbonyl, CO2R 5 or -C (=0)N(R 5 )R 5 ; R 15 is selected from: H; R 6 ; C1-C 1 0 alkyl, substituted with 0-3 R 6 ; C2-C10 alkenyl, substituted with 0-3 R 6 ; C1-C10 alkoxy, substituted with 0-3 R 6 ; aryl, substituted with 0-3 R 6 ; 5-6 membered heterocyclic ring containing 1-2 N, 0, or S heteroatoms, wherein said heterocyclic ring may be saturated, partially saturated, or fully unsaturated, said heterocyclic ring being substituted with 0-2 R 6 ; Ci-Cio alkoxycarbonyl substituted with 0-2 R 6 ; -CO2R 5 ; or -C(=0)N(R 12 )R 13 ; provided that when b is a double bond, only one of R 14 or R 15 is present; R 16 is selected from: -C(=0)-0-R 18a , -C(=0)-R 18b , -C(=0)N(R 18b ) 2 , -C(=0)NHS0 2 R 18a , -C(=0)NHC(=0)R 18b , -C(=0) HC(=0)OR 18 , -C (=0)NHSθ2NHR 18b , -C(=S)-NH-R 18b , -NH-C(=0)-0-R 18 , -NH-C(=0)-R 18b , -NH-C(=0) -NH-R 18b , -Sθ 2 -0-R 18a , -S0 2 -R 18a , -S0 2 -N ( 18 b) 2, -S0 2 -NHC(=0)018 b , -P(=S) (0R 18a ) 2 , -P(=0) (0R 18a ) 2 , -P ( =S) (R 18a ) 2 , -P(=0) (R 18a ) 2 , or R 17 is selected from: H, Ci-Cio alkyl, C 2 -C 6 alkenyl, C3-C11 cycloalkyl, C 4 -C 15 cycloalkylalkyl, aryl, aryl(Cι-Cιo alkyl)-; R 18a is selected from: Ci-Cβ alkyl substituted with 0-2 R 19 , C2-C 8 alkenyl substituted with 0-2 R 19 , C2-C 8 alkynyl substituted with 0-2 R 19 , C 3 -Cβ cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-4 R 19 , aryl (Ci-Cg alkyl)- substituted with 0-4 R 19 , a 5-10 membered heterocyclic ring system having 1-3 heteroatoms selected independently from 0, S, and N, said heterocyclic ring being substituted with 0-4 R 19 , Ci-Cg alkyl substituted with a 5-10 membered heterocyclic ring system having 1-3 heteroatoms selected independently from 0, S, and N, said heterocyclic ring being substituted with 0-4 R 19 ; Ri8b i s selected from R 18 or H; R 19 is selected from H, halogen, CF 3 , CN, NO 2 , NR 12 R 13 , Cj.- Cβ alkyl, C2~Cg alkenyl, C2-Cg alkynyl, C3-C11 cycloalkyl, C4-C 1 1 cycloalkylalkyl, aryl, aryl (Ci-Cg alkyl)-, Ci-Cg alkoxy, or C 1 -C 4 alkoxycarbonyl; R 20 and R 21 are each independently selected from H, C1-C10 alkyl, CO 2 R 5 , C(=0)R 5a , CONR 5 R 5a , NR 5 C(=0)R 5a , NR 12 R 13 , C 2 ~Cg alkenyl, C3-C 11 cycloalkyl, C 4 -C11 cycloalkylmethyl, Cg-Cio aryl, or C7-C 1 1 arylalkyl; R 22 is selected from C 1 -C 10 alkyl, C2~Cg alkenyl, C 3 -C 11 cycloalkyl, C4-C15 cycloalkylalkyl, aryl, aryl(Cι-Cιo alkyl)-; C(=0)R 5a , Cθ 2 R 5b , -C(=0)N(R 5 )R 5a , or a bond to X; provided that n, q and r are chosen such that the number of atoms connecting R 1 and Y is in the range of 8-17, 25. A compound of Claim 24 of Formula Ic: (ic) wherein: Z is selected from a bond, O, or S; R 2 and R 3 are independently selected from: H; Cι~Cg alkyl; C7-C 11 arylalkyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , SiO)mCH 3 , ~N{CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 1 -C 10 alkoxycarbonyl; aryl(Cι-Cιo alkoxy)carbonyl v/here the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-C alkoxy, Ci-Cg alkyl, CF 3 , S(0) m CH 3 , ~N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; or heteroaryl(C 1 -C 5 5 lkyl wherein the heteroaryl group is optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-Cg alkoxy, C1-C 5 alkyl, CF 3 , S(0) n ,CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; U is a single bond; X is -CHR 4a - ; R 5 is selected from H or Ci-Cio alkyl substituted with 0-6 R b ; R 6 and R 7 are each independently selected from H, Ci-Cio alkyl, hydroxy, Ci-Cio alkoxy, nitro, Ci-Cio alkylcarbonyl, -N(R 12 )R 13 , cyano, or halo; R 12 and R 13 are each independently selected from H, C -Cio alkyl, Ci-C o alkoxycarbonyl, Ci-Cio alkylcarbonyl, Ci-Cio alkylsulfonyl, aryl(Cι-Cιo alkyl) sulfonyl, arylsulfonyl, heteroarylsulfonyl, or aryl, wherein said aryls are optionally substituted with 0-3 substituents selected from the group consisting of: C 1 -C 4 alkyl, C 1 -C 4 .alkoxy, halo, CF 3 , and NO 2 ; R 15 is selected from H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 - Cio alkynyl, C1-C 1 0 alkoxy, aryl, heteroaryl or C 1 -C 10 alkoxycarbonyl, CO2R 5 or -C(=0)N(R 5 )R 5a ; R 16 is selected from: -C(=0)-0-R 18a , -C(=0)-R 18b , -S ( =0 ) 2 -R 18a ; R 17 is selected from: H or C 1 -C 4 alkyl; R 18a is selected from: Ci-Cs alkyl substituted with 0-2 R 19 , C2-C8 alkenyl substituted with 0-2 R 19 , C2-C8 alkynyl substituted with 0-2 R 19 , C3-C8 cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-2 R 19 , aryl(Cι-Cg alkyl)- substituted with 0-2 R 19 , a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, isoxazolyl, isoxazolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-2 R 19 ; Ci-Cg alkyl substituted with a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, isoxazolinyl, benzofuranyl, indolyl, indolenyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, indolyl, carbazole, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-2 R 19 . 26. A compound of Claim 24 of Formula lb: (lb) wherein: R 1 is selected from: R 2 <R 3 ) N- , R 2 NH (R 2 N= ) C- , R 2 R 3 N (CH 2 ) P - Z- , R 2 NH (R 2 N= ) CNH (CH 2 ) P ' Z- , R 2 (R 3 ) NC (O) - , R 2 ( R 5 05 N ( R 2 N= ) C - , R 2 ( R 3 J N ( R 5 ON= ) C - ; n is 0-1; p 1 is 2-4; p" is 4-6; Z is selected from a bond or O; R 3 is H or C 1 -C 5 alkyl; V is a single bond, or -(phenyl)-; X is selected from: -CH 2 -, -CHN(R 16 )R 17 -, or -CHNR 5 R 5a -; Y is selected from: hydroxy; Ci to Cio alkoxy; methylcarbonyloxymethoxy-; ethylcarbonyloxymethoxy-; t-butylcarbonyloxymethoxy-; cyclohexylcarbonyloxymethoxy-; 1-(methylcarbonyloxy)ethoxy-; 1-(ethylcarbonyloxy)ethoxy-; 1-(t-butylcarbonyloxy)ethoxy-; 1-(cyclohexylcarbonyloxy)ethoxy-; i-propyloxycarbonyloxymethoxy-; t-butyloxycarbonyloxymethoxy-; 1-(i-propyloxycarbonyloxy)ethoxy-; 1-(cyclohexyloxycarbonyloxy)ethoxy-; 1-( t-butyloxycarbonyloxy)ethoxy-; dimethylaminoethoxy-; diethylaminoethoxy-; (5-methyl-l,3-dioxacyclopenten-2-on-4-yl)methoxy-; (5-( -butyl)-1,3-dioxacyclopenten-2-on-4-yl)methoxy-; (1,3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methoxy-; 1-(2-(2-methoxypropyl)carbonyloxy)ethoxy-; R 18 is selected from: C 1 -C 4 alkyl substituted with 0-2 R 19 , C 2 -C 4 alkenyl substituted with 0-2 R 19 , C 2 -C 4 alkynyl substituted with 0-2 R 19 , C 3 -C 4 cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-2 R 19 , aryl(Cι-C 4 alkyl)- substituted with 0-2 R 19 , a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, isoxazolyl, isoxazolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted " " with 0-2 R 19 ; Ci-Cg alkyl substituted with a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, isoxazolinyl, benzofuranyl, indolyl, indolenyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, indolyl, carbazole, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-2 R 19 . 27. A compound of Claim 26 wherein: R 1 is R 2 NH(R 2 N=)C- or R 2 NH(R 2 N=)CNH- and V is phenyl or pyridyl; or R 1 is , and V is a single bond; n is 1-2; R 3 is H or C 1 -C 5 alkyl; X is selected from: -CH2-, -CHN(R 16 )R 17 -, or -CHNR 5 R 5a -; W is selected from: m is 1-3; Y is selected from: hydroxy; Ci to Cio alkoxy; methylcarbonyloxymethoxy-; ethylcarbonyloxymethoxy-; t-butylcarbonyloxymethoxy-; cyclohexylcarbonyloxymethoxy-; 1-(methylcarbonyloxy)ethoxy-; 1-(ethylcarbonyloxy)ethoxy-; 1-(t-butylcarbonyloxy)ethoxy-; 1-(cyclohexylcarbonyloxy)ethoxy-; i-propyloxycarbonyloxymethoxy-; t-butyloxycarbonyloxymethoxy-; 1-(i-propyloxycarbonyloxy)ethoxy-; 1-(cyclohexyloxycarbonyloxy)ethoxy-; 1-( -butyloxycarbonyloxy)ethoxy-; dimethylaminoethoxy-; diethylaminoethoxy-; (5-methyl-1,3-dioxacyclopenten-2-on-4-yl)methoxy-; (5-( -butyl)-1,3-dioxacyclopenten-2-on-4-yl)methoxy-; (1,3-dioxa-5-phenyl-cyclopenten-2-on-4-yl)methoxy-; 1-(2-(2-methoxypropyl)carbonyloxy)ethoxy-; R 19 is H, halogen, C 1 -C 4 alkyl, C 3 -C7 cycloalkyl, cyclopropylmethyl, aryl, or benzyl; R 20 and R 21 are both H; R 2 2 £s H, C 1 -C 4 alkyl or benzyl. 28. A compond of Claim 24, or a pharmaceutically acceptable salt form thereof, selected from: 2-(R,S)-2-carboxymethyl-l-{5-(R,S)-N-[3-(4- amidinophenyl)isoxazolin-5-yl acetyl]piperidine; 2-(R,S)-2-carboxymethyl-l-{5-(R,S)-N-[3-(4- amidinophenyl)isoxazolin-5-yl acetyl]azepine; 2-(R,S)-2-carboxymethyl-l-{5-(R,S)-N-[3-(4- amidinophenyl)isoxazolin-5-yl acetyl]pyrrolidine; 3-(R,S)-carboxymethyl-4-{5-(R,S)-N-[3-(4- amidinophenyl)isoxazolin-5-yl acetyl]piperazine-2- one; 6-(R,S)-carboxymethyl-l-{5-(R,S)-N-[3-(4- amidinophenyl)isoxazolin-5-yl acetyl]piperidine-2- one; 5-(R,S)-carboxymethyl-l-{5-(R,S)-N-[3-(4- amidinophenyl)isoxazolin-5-yl acetyl]pyrrolidine-2- one; 7-(R,S)-carboxymethyl-l-{5-(R,S)-N-[3-(4- amidinopheny1)isoxazolin-5-yl acetyl]azetidine-2-one; 2-(R,S)-carboxymethyl-l-{5-(R,S)-N-[3-(4- amidinophenyl)isoxazolin-5-yl acetylJpyrazolidine; 3-(R,S)-carboxymethyl-4-{5-(R,S)-N-[3-(4- amidinophenyl)isoxazolin-5-yl acetyl]morpholine. 29. A method for the prevention or treatment of thrombosis which comprises administering to a host in need of such treatment a therapeutically effective amount of a compound of Claim 1, 6, 11, 16, 20, or 24. 30. A pharmaceutical composition comprising a therapeutically effective amount of a compound of Claim 1, 6, 11, 16, 20, or 24 and a pharmaceutically acceptable carrier. 31. A method of inhibiting the aggregation of blood platelets which comprises administering to a host in need of such inhibition a therapeutically effective amount of a compound of Claim 1, 6, 11, 16, 20, or 24 . 32. A method of treating thromboembolic disorders selected from thrombus or embolus formation, harmful platelet aggregation, reocclusion following thrombolysis, reperfusion injury, restenosis, atherosclerosis, stroke, myocardial infarction, and unstable angina, which comprises administering to a host in need of such treatment a therapeutically effective amount of a compound of Claim 6. 33. A method for the treatment of thrombosis which comprises administering to a host in need of such treatment a therapeutically effective amount of a compound of Claim 6 in combination with one or more additional therapeutic agents selected from: a thrombolytic agent, an anti-coagulant agent, or an anti-platelet agent. 34. A method of treating rheumatoid arthritis, asthma, allergies, adult respiratory syndrome, organ transplantation rejection, septic shock, psoriasis, contact dermatitis, osteoporosis, osteoarthritis, tumor metastasis, diabetic retinopathy, inflammatory conditions and inflammatory bowel disease, comprising administering to a host in need of such treatment a therapeutically effective amount of a compound of Claim 6. 35. A compound of Claim 6, or enantiomeric or diasteriomeric forms thereof, or mixtures of enantiomeric or diasteriomeric forms thereof, or a pharmaceutically acceptable salt form thereof, selected from: M 3 -[2-{3-(4-formamidinophenyl) -isoxazoiin-5-yl}-acetyl] - N 2 - (phenyisuifonyl) -2 ,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinopheny1) -isoxazolin-5-y1}-acetyl] - N 2 -(4-methyl-phenyl-sulfonyl)-2,3-diaminopropanoic acid; N 3 -[2-(3- (4-f rmamidinophenyl) ~isoxazoiin~5-yi]-acetyl]- N 2 -(butanesulfonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl] - N 2 - (propanesulfonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoκazolin-5-yi}-acetyl] - N 2 -(ethanesuifonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5-yi}-acetyl]- N 2 -(methyloxycarbonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] - N 2 - (ethyloxycarbonyl) -2, 3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yi}-acetyl] - N 2 - (1-propyloxycarbonyl} -2,3-diaminopropanoic acid; N 3 ~ [2-{3- (4-formamidinopheny.15 -isoxazolin-5-yl}-acetyl] - N 2 - (2-propyloxycarbonyl) -2,3-diaminopropanoic acid; N 3 - [2-{3- ( -formamidinophenyl) -isoxazoiin-5-yl}-acetyl] - N 2 - (n-butyloxycarbonyl) -2,3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazoiin-5-yl}-acetyl] - N - (1- (2-methyl) -propyloxycarbonyl) -2,3- diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazoiin-5-yl}-acetyl] - N 2 - (2- {2-methyl) -propyloxycarbony!5-2,3- diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yl)-acetyl] - N - (benzyloxycarbonyl) -2, 3-diaminopropanoic acid; N 3 - [2-{3- (4-f rmamidinophenyl) -isoxazoiin-5-yl}-acetyl] - N 2 - (4-methylbenzyloxycarbony1) -2,3-diaminopropanoic acid; N 3 - " [2-{3- (4-formamidinophenyl) -isoxasoiin-5-yl}-acetyl] - N 2 - {4-methoxybenzyloxycarbony1) ~2,3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazoiin-5-yl)-acetyl] - N 2 - (4-chlorobenzyloxycarbonyl) -2,3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] - N 2 - ( -bromobenzyloxycarbonyl) -2,3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinopheny15 -isoxazoiin-5-yi}-acetyl] - N 2 - (4-fluorobenzyloxycarbonyl) -2, 3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazolin-5-yi}-acetyl] - N 2 - (4-phenoxybenzyloxycarbony15-2,3-diaminopropanoic acid; N 3 - [2-{3- (4-formamidinophenyl) -isoxazoiin-5-yl}-acetyl] - N 2 - (2- (methyioxyethyl) -oxycarbonyi) -2,3- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -•isoxazolin-5-yl}-acetyl] - N 2 - (2-pyridiπylcarbonyl) - ,3-diaminopropanoic acid; N 3 -[ -{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl]- N 2 -(3-pyridinylcarbonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3- ( -forma idinophenyl5 -iεoxazoiin-5-yl}-acetyl]- N 2 -14-pyridinyl-carbonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazoiin-5-yl)-acetyl]- N 2 - (2- (2-pyridinyl) -acetyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazoiin-5-yl]-acetyl]- N 2 -(2- (3-pyridinyl) -acetyl)-2,3-diaminopropanoic acid; N -[2-{3-( -formamidinophenyl5 -isoxazolin-5-yl}-acetyl]- N 2 - ( 2- ( -pyridinyl)-acetyl)-2, -diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -iεoxazoiin-5-yl>-acetyl] - -(2-pyridyl-methyloxycarbonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazoiin-5-yl}-acεεyl] - N 2 - (3-pyridyl-methyloxycarbonyl)- , -diaminopropanoic acid; N 3 -[2-{3-(4-formamidinopheny15 -iscκazolin-5-y1}-acetyl] - N 2 -(4-pyridyl-methyloxycarbonyl)- ,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxa oiin-S-yl}-acetyl] - N - ( -butyloxyphenyi≤ulfonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazoiin-5-yl}-acetyl] - N 2 - (2-thienylsulfonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoκazolin-5-yl}-acetyl] - N 2 -(3-methylphenylsulfonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3- (4-formamidinophenyl) -isoκa oiin-5-yl}-aσetyl] - N 2 - (4-iodophenylsulfonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl5 -isoxazolin-5-yi}-ace yl]- N 2 - (3-trifluoromethylphenylsulfonyl)-2,3- diaminopropanoic acid; N 3 -[2-{3- (4-formamidinophenyl) -isoκazolin-5-yl}-acetyl] - N 2 - (3-chlorophenylsulfonyl ) -2 , 3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] - N 2 - (2-methoxycarbonylphenylsulfonyl) -2,3- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazoiin-5-yl)-acetyl] - N 2 -{2,4,6-trimethylphenylsulfonyl)-2,3- diaminopropanoic acid; N 3 -[2-{3-( -formamidinophenyl) -isoxazolin-5-yl}-acetyl] - N 2 -(2-chlorophenylsulfonyl5-2,3-diaminopropanoic acid; N 3 -[2-{3-( -formamidinophenyl5-isoxazoiin-5-yl}-acetyl]- N 2 -(4-trifluoromethylphenylsul onyl)-2,3- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] - N 2 -{2-trifluoromethylphenylsulfonyl) -2,3- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5-yi}-acetyl] - N 2 -(2-fluorophenvlsulfonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinopheny1) -isoxazolin-5-y1}-ace yl] - N 2 -(4-fluorophenvlsulfonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoκazoiin-5-yl}-acetyl] - N 2 - (4-methoxyphenylsulfonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidi ophenyl) -isoxazolin-5-y1}-acetyl] - N 2 - (2,3,5,6-tetramethylphenylsulfonyl5-2,3- diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazolin-5-yl}-acetyl]- N 2 -(4-cyanophenylsulfony1)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] - N 2 - (4-chlorophenylsulfonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazoiin-5-yi}-acetyl] - N 2 - (4-propylphenylsulfonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazoiin-5-yl}-acetyl] - N 2 - (2-phenylethyisuifonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyi) -isoκazoiin-5-y1}-acetyl] - N 2 - (4-isopropylphenylsulfonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl)-isoxazoiin-5-yl}-acetyl] - N 2 - (3-phenylpropy1su1fony1) -2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazoiin-5-yl}-acetyl] - N 2 - (3-pyridylsulfonyl) -2 ,3-diaminopropanoic acid? N 3 -[2-{3- (4-formamidinophenyl) -isoκazolin-5-yl}-acetyl] - N 2 - (phenyia inoεulfonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl5 -isoxazolin-5-yi}-acetyl]- N 2 -(benzylaminosulfonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazolin-5-yl)-acetyl]- N 2 - (dime h laminosulfonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(2-fluoro-4-formamidinophenyl)-isoxazolin-5-yl}- acetyl]-N 2 - (3-methylphenyls lfonyl5-2,3- diami opropanoic acid; N 3 -[2-{3-(2-formamidino-5-pyridinyl)-iεoxazolin-5-yl}- acetyl]-N 2 -(n-butyloxycarbonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(2-formamidino-5-pyridinyl) -isoxazolin-5-yl)- acetyl]-N 2 - ( -m thylphenylsulfonyl) -2,3- diaminopropanoic acid; N 3 -[2-{3-(3-formamidino-6-pyridinyl5 -isoxazolin-5-yl}- acetyl]-N Ξ - (n-butyloxycarbonyl5-2,3-diaminopropanoic acid, N 3 -[2-{3-(3-formamidino-6-pyridinyl)-isoxazolin-5-yl}- acetyi]-N 2 - (3-methylphenylsulfonyl) -2,3- diaminopropanoic acid, N 3 -T2-{3-(4-formamidinophenyl5 -isoxazolin-5-yl}-ace yl] - N 2 -(phenyiaminocarbonyl) -2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazoiin-5-y1}-acetyl] - N 2 - ( -fluorophenylaminocarbonyl)-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] - N 2 - (1-naphthylaminocarbony )-2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] - N 2 -(benzylaminocarbonyl5 -2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinopheny1) -isoxazoiin-5-y1}-acetyl] - N 2 - (3-bromo-2-thienylsuif nyl) -2,3-diaminopropanoic acid; N 3 -[2-{3-(4-formamidinopheny1) -isoxazoiin-5-yl}-acetyl] - N 2 - (3-methγl-2-benzothienylsulfonyl) -2,3- diaminopropanoic acid, N 3 -[2-{3-(4-formamidinophenyl) -iscxazolin-5-yl}-acetyl] - N 2 -(isobutyloxycarbonyl5 -2,3-diaminopropanoic acid, N 3 -[2-{3-(4-formamidinophenyl) -isoxazolin-5-yl}-acetyl] - N 2 - (isobutyloxycarbonyl) -2,3-diaminopropanoic acid, N 3 -[2-{3-(4-formamidinophenyl) -isoxazoiin-5-yl}-acetyl] - N 2 -(isobutyloxycarbonyl) -2,3-diaminopropanoic acid, N 3 -[2-{3-( -forma idinophenyl5 -isoxazoiin-5-yl}-acetyl] - N 2 -(2-cyclopropylethoxycarbonyl) -2,3-diaminopropanoic acid, N 3 -[2-{3-( -guanidinopheny1) -isoxazolin-5-yl}-acetylj-N 2 - (n-butyloxycarbonyl)-2, -diaminopropanoic acid; N 3 -[2-{3-{ -guanidinopheny1) -isoxazolin- 5-yl}-acetyl] -N 2 - (3-methylphenylsulfonyl)-2,3-diamincpropanoic acid; N 3 -[2-{5-(4-formamidinophenyl) -isoxazoiin-3-yl}-acetyl] - N 2 - (n-butyloxycarbonyl)-2,3-dia inopi panoic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoxazoiin- ; -yl}-acetyl] - N 2 -(2-bromo- henylεulfonyl)-2,3-diaminopropionic acid; N 3 -[2-{3-(4-formamidinophenyl) -isoκazoiin-5- / l}-acetyl] - N 2 - (2-methyl-phenylsulfonyl)-2,3-diamin.propionic acid; N 3 -[2-{3-(3-formamidino-6-pyridinyl)-isoxazclin-5-yl}- acetyl]~N 2 - (3-methylphenylsulfony15 -2,3- diaminopropionic acid; N 3 -[2-{3-(2-formamidino-5-pyridinyl)-iεoxazclin-5-yl}- acetyl]-N 2 - (3-methyiphenyls 1fonyl5-2,3- diaminopropionic aci ; N 3 -[2-{3-(2-fluoro-4-formamidinophenyl) -isoxazolin-5-yl}- acetyl]-N 2 - (3-methylphenylsulfonyl) -2,3- diaminopropionic acid; M 3 -[2-{3-(4-f rmamidinophenyl) -isoxazoiin-5-yi}-acetyl] - N 2 -(3-bromo-phenylsulfonyl)-2,3-diaminopropionic acid; N 3 -[2-{3- ( -formamidinophenyl5-isoxazoiin-5-yl}-acetyl] - N 2 -(4-bromo-phenylsulfonyl) -2 , 3-diaminopropionic acid; said enantiomeric and diasteriomeric forms being selected from: (R, S) , (R. S) ; (R) , (R, S) ; ( S) , I R, S) ; (R) , (R) ; ( S) , (J?) ; (R ) , ( 3) ; (S) , ( S) . 36. A compound of Claim 35, or enantiomeric or diasteriomeric forms thereof, or mixtures of enantiomeric or diasteriomeric forms thereof, or a pharmaceutically acceptable salt form thereof, said enantiomeric and diasteriomeric form being: (R) , ( S) . 37. A prodrug ester of a compound of Claim 35, or enantiomeric or diasteriomeric forms thereof, or mixtures of enantiomeric or diasteriomeric forms thereof, or a pharmaceutically acceptable salt form thereof, said ester being selected from the group consisting of: methyl; ethyl; isopropyl; methylcarbonyloxymethyl-; ethylcarbonyloxymethyl- ? t-buty1carbony1oxymethy1-; cyclohexyicarbonyloxymethyl-; 1- (methylcarbonylox ) ethyl-; 1- ;ethylcarbonyloκy5ethyl-; 1- (t-butylcarbonyloxy) ethyl-; 1- (cyclohexyicarbonyloxy) ethyl-; i-propyloxycarbonyloxym thy1-; cyclohexyicarbonyloxymethyl-; t-buty1oxycarbony1oxy ethy1-; 1- {i-propyloxycarbonyloxy) ethyl-; 1- (cyclohexyloxycarbonyloxy) ethyl-; 1- {t-butylcxycarbαnyloκy) ethyl-; dimethylaminoethy1-; diethylaminoethyl-; (5-methyl-l, 3-dioxacyclopenten-2-on-4-yl)methyl-; {5- ( -butyl) -1,3-dioxacyclopenten-2-on~4-yl5methyl- ; (1,3-dioxa-5-phenyl-eyelopenten-2-on-4-y15methyl-; 1- (2- (2-methoxyρrcpyl) carbonyloxy) ethyl- . 3S. A prodrug ester of a compound of Claim 36, said ester being selected from the group consisting of: methyl; ethyl; isopropyl. 39. A process for preparing a compound of the formula X (X) wherein: R 4 is selected from: H, Cχ-Cιo alkyl, Ci-Cio alkylcarbonyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; R 4a is selected from: H, hydroxy, Ci-Cio alkoxy, nitro, N( 5 )R 5a , -N(R 12 JR 13 , -N(R i£ )R 17 , Ci-Cio alkyl substituted with 0-3 R 6 , aryl substituted with 0-3 R δ , or i-Cio alk lcarbonyl; R 4b is selected from H, Ci-Cβ alkyl, C -C/ 5 alkenyl, C 2 -C6 alkynyl, C -C7 cycloalkyl, C 7 -C 14 bicycloalkyl, hydroxy, Ci-Cg alkoxy, Cχ-Ce aikylthio, Cχ-Cg alkylsulfinyl, i-Cg alkylsulfonyl, nitro, Cχ-Cg alkylcarbonyl, Cg-Cχo aryl, -N(R 12 )R 13 ; halo, CF3, CN, Ci-Cg alkoxycarbonyl, carboxy, piperidinyl, morpholinyl or pyridinyl; R 5 is selected from H or C 1 -C 1 0 alkyl substituted with 0-2 R 4b ; R 5 is selected from hydrogen, hydroxy, Ci to Ca alkyl, C3- C alkenyl, C3 to Cn cycloalkyl, C4 to Cn cycloalkylmethyl, Cχ-Cg alkoxy, benzyloxy, Cg to Cio aryl, heteroaryl, heteroarylalkyl, C 7 to Cn arylalkyl, adamantylmethyl, or Cχ-Cχo alkyl substituted with 0-2 R b ; R δ is selected from H, C 1 -C 4 alkyl, hydroxy, C 1 -C 4 alkoxy, nitro, C 1 -C 1 0 alkylcarbonyl, -N(R 12 »R 13 , -NR 5 R 5 , CO2R 5 , S(0) ιn R 5 , OR 5 , cyano, halo; Cg to Cχo aryl optionally substituted with 1-3 groups selected from halogen, Cχ-Cς alkoxy, Cι~Cg alkyl, CF 3 , S(0)mMe f or -NMes; methyienedioxy when R 6 is a substituent on aryl; or a heterocyclic ring system selected fi-om pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3tf-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, isoxazolyl, isoxazolinyl or morpholinyl; R s is selected from: -CONR 5 NR 5a ; -CO2R 5 ; C 1 -C 1 alkyl, substituted with 0-3 R 6 ; C2-C10 alkenyl, substituted with 0-3 R 6 ; C2- 10 alkynyl, substituted with 0-3 R 6 , 3 -C 8 cycloalkyl, substituted with 0-3 R 6 ; aryl, substituted with 0-2 R 6 ; a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, isoxazolyl, isoxazolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3H-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-2 R 6 ; R 12 is selected from H, Cχ-Cg alkyl, C 1 -C 4 alkoxycarbonyl, Cχ-Cg alkylcarbonyl, Cχ-Cg alkylsulfonyl, aryl (C1-C 4 alkyl5sulfonyl, arylsulfonyl, aryl, heteroaryisuifonyl, pyridylcar onyl or pyridylmethylcarbony1, wherein said aryls are optionally substituted v/ith 0-3 substituents selected from the group consisting of: C 1 -C4 alkyl, C1-C 4 alkoxy, halo, CF3, and NO 2 ; and R 13 is H. R 16 is selected from: -C(=0)-C-R i8a , ~Ci=0;~R 18b , -C ( =0 ) N ( R 18b) 2 , -Sθ2-R 18 , or -Sθ2-N ( R 18b) 2 ; R 17 is selected from: H or C1-C4 alkyl R 18a is selected from: Ci-Cs alkyl substituted with 0-2 P. 19 , C 2 - 8 alkenyl substituted with 0-2 R 19 , C2-C, alkynyl substituted with 0-2 R 1:? , C3-C 3 cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-4 R 19 , aryl (Ci-Cg alkyl;- substituted with 0-4 R 19 , a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, isoxazolyl, isoxazolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyrimidinyl, 3 H-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-4 R 19 ; Ci-Cg alkyl substituted with a heterocyclic ring " system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, isoxazolinyl, benzof ranyl. indolyl, indolenyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 2H-indolyl, indolyl, carbazole, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-4 R 19 ; R 1Sb is selected from R i8a or H; R 19 is selected from H, halogen, CF3, CN, NC-, NR 12 R 13 , Ci- Cs alkyl, Cα-C alkenyl, C^-Cg alkynyl, C 3 -C1 1 cycloalkyl, C 4 -C 11 cycloalkylalkyl, aryl, aryl(Cχ-Cg alkyl)-, Ci-Cg alkoxy, or C 1 -C 4 alkoxycarbonyl; m is 0-2; n is 0-4; q is 1-7; and r is 0-3; said process comprising the steps of: eprotecting a compound of the formula IX ( IX) wherein : R 1 is HR 2 N-C (=NR 2 ) -, NC-, HR 2 N-C (=NHR 2 ) -NH-, or HR 2 N-; R 2 and R 3 are independently H, C 2 -C 7 alkylcarbonyl; C 7 -C 11 arylcarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Cχ-Cg alkoxy, Cχ-Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; Cχ-Cιo alkoxycarbonyl; C 4 -C 11 cycloalkoxycarbonyl; C 7 -C 11 bicycloalkoxycarbonyl; C7-C 1 1 aryloxycarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Cχ-Cg alkoxy, Cχ-Cg alkyl, CF 3 , S ( 0 ) m CH3, -N ( CH 3 ) 2 , C1-C4 haloalkyl, methylenedioxydiy1, ethylenedioxydiyl; aryl (C 1 -C1 0 alkoxy)carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Cχ-Cg alkoxy, Cχ-Cg alkyl, CF 3 , (0)mCH3, -N(CH 3 )2- C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; Cχ-Cg alkylcarbonyloxy(C 1 -C 4 alkoxy) carbonyl; Cg-Cio arylcarbonyloxy(C 1 -C4 alkoxy)carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Cχ-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0)mCH 3 , -N(CK 3 ) 2 , C 1 -C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C4-C1 1 cycloalkylcarbonyloxy(C 1 -C4 alkoxy)carbonyl; heteroaryl optionally substituted v;ith 0-2 groups selected from hydroxy, halogen, Cχ-Cg alkoxy, Cχ-Cg alkyl, CF 3 , S(0) m CH 3 , -N(013) 2 , C 1 -C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; or heteroaryl (C 1 -C 5 ) lkyl wherein the heteroaryl group is optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cς alkyl, CF 3 , S(0) n ,CH 3 , -N{CH 3 ) 2 , C 3 -C 4 haloalkyl, methylenedioxydiyl, e h lenedioxydiy1; Y is selected from Ci to Cio alkyloxy, C 3 to Cn eyeloalkyloxy, Cg to Cχo aryloxy, C 7 to Cn aralkyloxy, C 3 to io aikylcar onyloxyalleyloxy, C^ to Cio alkoxycarbonyloxyalkyloxy, C to Cio alkoxycarbαnylalkyloxy, Cς to Cχo cycloalkylcarbonyloxyalkyloxy, C5 to Cχo eyeloalkoxycarbon lox aIkyloxy, C5 to Cio cycloalkoxycarbonylalkyloxy, C7 to Cn aryloxycar onylaIkyloxy, Cg to C 12 aryloxycarbonyloxyalkyloxy, Ca to C 12 arylcarbonyloxy lk loxy, C5 to Cχo alkoxyalkylcarbonyloxyalkyloxy, C5 to Cχo (5-alkyl- 1,3-dioxa-cyclopenten-2-one-yl) ethyloxy, Cio to C14 {5-ary1-1,3-dioxa-cyclopenten~2-one-y1) ethyloxy, (R 2 ) (R )N-(C 1 -Ci0 alkoxy)-; is 0-2; n is 0-4; and all other substituents are as defined above; under acidic, basic, catalytic, and/or enzymatic conditions to provide a compound of formula (X) as defined above. 40. A process according to Ciaim 39 further comprising the step of: contacting a compound of the formula VII (VII; with a compound of the formula VIII (VIII ; under peptide bond forming conditions to effect the formation of a peptide bond and form a compound of the formula (IX) wherein ail substituents are as defined in Claim 39. 41. A process according to Ciaim 40 further- comprising the steps of: contactin a compound of the formula V • wherein X is chloro, bromo or iodo, in the presence of a hindered amine base with a compound of the formula VI (VI) wherein R is alkyl or other group removable under basic conditions to form a compound of the formula Vila (Vila) v;herein all other substituents are as defined in Claim 40; and hydrolyzing a compound of the formula Vila under mild basic conditions to form a compound of the formula 42. A process according to Ciaim 40 further comprising the step of: resolving the two stereoisomers of a compound of the formula VII, wherein R 4 is H, by chemical resolution with ctn appropriate optically pure chiral amine to form the separated (+) and (-) isomers of a compound of the formula VII. 43. A process_according to Ciaim 40 further comprising the step of: resolving the two stereoisomers of a compound of the formula VII ιy chiral chromatography to form the separated (+) • and (-) isomers of a compound of tho formula VII. 44. A process according to Ciaim 40 further comprising the step of: resolving the two stereoisomers of a compound of the formula Vila by chiral chromatography to form the separated (+) and (-5 isomers of a compound of the formula Vila. 45. A compound of the formula IX (IX) wherein: Y is selected from Ci to Cχo alkyloxy, C 3 to n cycloalkyloxy, Cg to Cio aryloxy, C7 to Cn aralkyloxy, C 3 to Cio alkylcarbonyloxyalkyloxy, C3 to Cio alkoxycarbonyloxyalkyloxy, C 2 to Cio alkoxycarbonylalkyloxy, C 5 to Cχo cycloalkyicarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonyloxyalkyioxy, C 5 to Cio cycloalkoxycarbonylalkyloxy, C 7 to Cn aryloxycarbonylaIkyloxy, Cg to C 12 aryloxycarbonyloxyalkyloxy, C9 to 12 arylcarbonyloxyalkyloxy, C 5 to Cio alkoxyalkylcarbonyloxyalkyloxy, C to Cio (5-alkyl- 1,3-dioκa-cyclopenten-2-one-yl) ethyloxy, Cio to C14 (5-aryl-1,3-dioxa-cyclopenten-2-one-yl)methyloxy; R 1 is NC-; R 4 is selected from: H, C1-C10 alkyl, Cj-Cio alkylcarbonyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; R 4a is selected from: H, hydroxy, Cχ-Cιo alkoxy, nitro, N(R 5 ) R 5a , -N(R 12 )R 13 , -N(R 16 )R 17 , C1-C10 alkyl substituted with 0-3 R 6 , aryl substituted with 0-3 P. 6 , or C1-C10 alkylcarbonyl; R 4b is selected from: H, Ci-Cg alkyl, C2~C alkenyl, C2-Cg alkynyl, C3-C7 cycloalkyl, C7-C14 bicycloalkyl, hydroxy, Cχ-Cg alkoxy, Cχ-Cg alkylthio, Cι~Cg alkylsulfinyl, Cχ-Cg alkylsulfonyl, nitro, Ci-Cg alkylcarbonyl, Cg-Cχo aryl, -N(R 12 )R 13 ; halo, CF3, CN, Ci-Cg alkoxycarbonyl, carboxy, piperidinyl, morpholinyl or pyridinyl; R 5 is selected from H or Cι-Cχo alkyl substituted with 0-2 " ' R 4 ; R 5 is selected from hydrogen, hydroxy, Ci to C3 alkyl, C3- Cg alkenyl, C3 to Cn cycloalkyl, C4 to Cn cycloalkylmethyl, Ci-Cg alkoxy, benzyloxy, Cg to Cio aryl, heteroaryl, heteroarylalkyl, C7 to Cn arylalkyl, adamantylmethyl, or C1-C10 alkyl substituted with 0-2 R 4b ; R 6 is selected from H, C1-C4 alkyl, hydroxy, C1-C4 alkoxy, nitro, C1-C10 alkylcarbonyl, -N(R 12 )R 13 , -NR 5 R 5a , C0 2 R 5 , S(05 m R 5 , OR 5 , cyano, halo; Cg to Cio aryl optionally substituted with 1-3 groups selected from halogen, Ci-Cg alkoxy, Cχ-Cg alkyl, CF3, methyleneαioxy when R 6 is a substituent on aryl; or a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl. pyridinyl, 3if-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, isoxazolyl, isoxazolinyl or morpholinyl; R 3 is selected from: -CONR 5 NR 5a ; -CO 2 R 5 ; C1-C10 alkyl, substituted with 0-3 F: β ; C2-C 1 0 alkenyl, substituted with 0-3 R 6 ; C2-C10 alkynyl, substituted with 0-3 R 6 , C3-C8 cycloalkyl, substituted with 0-3 R s ; aryl, substituted with 0-2 R 6 ; a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoσuinolinyl, isoxazolyl, isoxazolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3ff-indoiyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-2 R 6 ; R 12 is selected from H, Cχ-Cg alkyl, C1-C 4 alkoxycarbonyl, Cχ-Cg alkylcarbonyl, Cχ-Cg alkylsulfonyl, aryl(Cχ-C 4 alkyl)sulfonyl, heteroarylsulfonyl, arylsulfonyl, aryl, pyridylcarbonyl or pyridylmethylcarbonyl, wherein said aryls are optionally substituted with 0-3 substituents selected from the group consisting of: C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , and NO 2 ; and P. 13 is H. R 16 is selected from: -C(=0)-0-R 18 , -C(=0)-R 1Sb , -C ( =0 ) N ( R 18b) 2 * -Sθ2-R 18a , or -Sθ2-N ( R 18b ) 2 ; R 17 is selected from: H or C 1 -C 4 alkyl R 18a is selected from: Ci-Cs alkyl substituted with 0-2 P. 19 , C 2 -C 8 alkenyl substituted with 0-2 R 19 , C 2 -C 8 alkynyl substituted with 0-2 R 19 , C3-C 3 cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-4 R 15 , aryl(Cι-Cg alkyl)- substituted with 0-4 R 19 , a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, benzofuranyl, indolyl, indolinyl, quinolinyl, isoquinolinyl, isoxazolyl, isoxazolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyrimidinyl, 3?f-indolyl, carbazolyl, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-4 R i9 ; Ci-Cg alkyl substituted with a heterocyclic ring system selected from pyridinyl, furanyl, thiazolyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, isoxazolyl, isoxazolinyl, benzofuranyl, indolyl, indolenyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, tetrahydrofuranyl, pyranyl, pyridinyl, 3if-indolyl, indolyl, carbazole, pyrrolidinyl, piperidinyl, indolinyl, or morpholinyl, said heterocyclic ring being substituted with 0-4 Fι 19 ; R lSb i s selected from R i8a cr H; R 19 is selected from H, halogen, CF 3 , CN, NO 2 , NR 12 R 13 , Ci- Ca alkyl, C2-Cg alkenyl, C2~C alkynyl, C 3 -C 11 cycloalkyl, C 4 -C 11 cycloalkylalkyl, aryl, aryl(Cι-Cg alkyl)-, Cχ-Cg alkoxy, or C 1 -C 4 alkoxycarbonyl; is 0-2; n is 0-4; σ is 1-7; and r is 0-3. 46. A compound of the formulae VII or Vila wherein: R is H, alkyl, or other- group removable under basic conditionε; R 1 is HR 2 N-C(=NR 2 )-, NC-, HR 2 N-C (=NHR 2 ) -NH-, or HR 2 N-; R 2 is H, C 2 -C7 alkylcarbonyl; C 7 -C 11 arylcarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Cχ-Cg alkoxy, Cχ-Cg alkyl, CF3, S(0) m CH3, -N(CH 3 5 2 , C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C1-C10 alkoxycarbonyl; C 4 -C11 cycloalkoxycarbonyl; C 7 -C 11 bicycloalkoxycarbonyl; C 7 -C 11 aryloxycarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy-, Cχ-C'g alkyl, CF 3 , S(0) πι CH3, -N(CH 3 )2, C1-C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; aryl (C 1 -C10 alkoxy) carbonyl v/here the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0) n CH3, -N ( CH 3 )2, C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; Ci-Cg alkylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl; Cg-Cio arylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Cχ-Cg alkoxy, Cχ-Cg alkyl, CF 3 , S(0) m CH3, -N(0* 3 ) , C1-C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 4 -C 11 cycloalkylcarbonyloxy(C 1 -C 4 alkoxy)carbonyl; heteroaryl optionally substituted with 0-2 groups selected from hydroxy, halogen, Cχ-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0) πι CH3, -N(CH 3 )2« C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; or heteroaryl (C1-C5)alkyl where the heteroaryl group is optionally substituted with 0-2 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF3, S(0) m CH3, -N(CH3)2, C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; R 4 is selected from: H, Cι~Cχo alkyl, Cχ-Cχo alkylcarbonyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; m is 0-2; n is 0-4; 47. A compound of the formulae le or If (if) or enantiomeric or diasteriomeric forms thereof, or mixtures of enantiomeric or diasteriomeric forms thereof, or a pharmaceutically acceptable salt form thereof, wherein: R 1 is R 2 (R 3 )N{R 2 N=)C-, R 2 (R 3 )N(R 2 N=)CN(R 2 ) -, or R (R 3 )N-; R 2 and R 3 are independently selected from: H; Cχ-Cιo alkyl; C3-C6 alkenyl; C3-C11 cycloalkyl; C4-C 11 cycloalkylalkyl; Cg-Cχo aryl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF 3 , S(0) m CH 3 , -N(CK 3 ) 2 , C 1 -C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C7- Cn arylalkyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Cχ-Cg alkoxy, Cχ-Cg alkyl, CF3, S(0) m CH 3 , -N(CH 3 )2, C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C2-C 7 alkylcarbonyl; C7-C 11 arylcarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Cχ-Cg alkoxy, Cχ-Cg alkyl, CF 3 , S(0)mCH 3 , -N(CH 3 >2, C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; Ci-Cio alkoxycarbonyl; C 4 -C11 cycloalkoxycarbonyl; C 7 -C 11 bicycloalkoxycarbonyl; C 7 - C 11 aryloxycarbonyl optionally substituted with 0-3 groups selected from hydroxy, halogen, Ci-Cg alkoxy, Ci-Cg alkyl, CF3, S-IOJmCHs, -N(013)2, C3.-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; aryl (C1-C 10 alkoxy) carbonyl where the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Cχ-Cg alkoxy-, Cχ-Cg alkyl, CF3, S(0)mCH 3 , -N{CH 3 ; 2 , C 3 .-C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; Ci-Cg alkylcarbonyloxy(Cχ-C4 alkoxy)carbonyl; Cg-Cχo arylcarbonyloxy(C1-C4 alkoxy)carbonyl v/here the aryl group is optionally substituted with 0-3 groups selected from hydroxy, halogen, Cχ-Cg alkoxy, Cχ-Cg alkyl, CF 3 , S(0) m CH 3 , -N(CH 3 ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; C 4 -C11 cycloalkylcarbonyloxy(C 1 -C4 alkoxy)carbonyl; heteroaryl optionally substituted with 0-2 groups selected from hydroxy, halogen, Cχ-Cg alkoxy, Cχ-Cg alkyl, CF 3 , S(0) m CH 3 , ~N(CH ) 2 , C 1 -C 4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; or heteroaryl (C 1 -C 5 )alkyl v/here the heteroaryl group is optionally substituted with 0-2 groups selected from hydroxy, halogen, i-Cg alkoxy, Cχ-Cg alkyl, CF 3 , S(0) n ,CH 3 , -N(CH3)2, C1-C4 haloalkyl, methylenedioxydiyl, ethylenedioxydiyl; provided that only one of R 2 and R 3 may be hydroxy; R 12 and R 13 are independently H, Cχ-Cχo alkyl, Cχ-Cιo alkoxycarbonyl, Cχ-Cιo alkylcarbonyl, C1-C10 alkylsulfonyl, aryl (Cχ-Cχo alkyl)sulfonyl, arylsulfonyl, aryl (C2-C 1 0 alkenyl5sulfonyl, heteroarylsuifonyl, aryl, C2~C alkenyl, C 3 ~Cii cycloalkyl, C4-C11 cycloalkylalkyl, C7-C11 arylalkyl, C 7 -C 1 1 arylcarbonyl, C4-C1 1 cycloalkoxycarbonyl, C7- Cχι bicycloalkoxycarbonyl, C7-Cχχ aryloxycarbonyl, heteroaryicarbonyl, heteroaryialkylcarbonyl, or aryl (Ci—Cio alkoxy) carbonyl , wherein said aryls are optionally substituted with 0-3 substituents selected from the group consisting of: C 1 -C4 alkyl, C 1 -C 4 alkoxy, halo, CF 3 , and NO 2 ; R 1G is selected from: -C(=0)-0-R 18 , -C(=0)-R 18b , -C ( =0 ) N ( R 18b) 2 , -Cl=0 ) NHS02R 18a , -C (=0) HC{=0)R 18 , -C {=0)NHC (=0)OR 18a , -C (=05NHSθ2NKR i8b , -C!=S5~NH-R 18b , -NH-C(=0)-C-R 18a , -NH-C(=0)-R 18b , -NH-C(=0) -NH-R i8b , -S02-0-R 18 *, -Sθ2-R 18a , -S0 2 -N ( 13 b) 2 , -SO2-NHC{=0)018 b , -P(=S) (OR 18 ) 2 , -P ( =0 ) (OR 18a) 2 , -P ( =S ) ( R 1Sa) 2, -P ( =0 ) ( R 18a) 2» or p v l8a i c s seleccted from: C1-C 3 alkyl substituted with 0-2 R 19 , C 2 -C 8 alkenyl substituted with 0-2 R 19 , C -Cs alkynyl substituted with 0-2 R 1S , C 3 -C 8 cycloalkyl substituted with 0-2 R 19 , aryl substituted with 0-4 R 19 , aryl(Cι-Cg alkyl)- substituted with 0-4 R 19 , a 5-10 membered heterocyclic ring system having 1-3 heteroatoms selected independently from 0, S, and N, said heterocyclic ring being substituted with 0-4 R l -\ Ci-Cg alkyl substituted with a 5-10 membered heterocyclic ring system having 1-3 heteroatoms selected independently from O, S, and N, said heterocyclic ring being substituted with 0-4 F 19 ; R 1 8b is selected from R 18a or H; R 19 is selected from K, halogen, CF 3 , CN, Os, NR 12 R 13 , Ci- Cs alkyl, C 2 ~Cg alkenyl, Cs-Cg alkynyl, C 3 -C 11 cycloalkyl, C 4 -C 11 cycloalkylalkyl, aryl, aryl(Cχ-Cg alkyl}-, Cχ-Cg alkoxy, or C 1 -C 4 alkoxycarbonyl; Y is selected from hydroxy, Ci to Cχo alkyloxy, C 3 to Cn cycloalkyloxy, Cg to C' 1 0 aryloxy, C7 to Cχι aralkyloxy, C to Cχo alkylcarbonyloxyalkyloxy, C 3 to Cio alkoxycarbαnyloxyalkyloxy, C 2 to Cio alkoxycarbonylalkyloxy, Cς to Cio cycloalkyicarbonyloxyalk loxy, C 5 to Cχo cycloalkoxycarbonyloxyalkyloxy, C 5 to Cio cycloalkoxycarbonylalkyloxy, C 7 to Cn aryloxycarbonylaIkyloxy, Cg to C 12 aryloxycarbon loxyalkyloxy, Cg to C1 arylcarbonyloxyalkyloxy, C5 to Cχo alkoxyalkylcarbonyloxyalkyloxy, Cs to Cio (5-alkyl- l,3-dioκa-cyclopenten-2-one-yi)methyioκy, Cχo to C14 (5-ary1-1,3-dioκa-cyclopenten~2-one~yl)methylox , (R 2 ) (R 3 ) -(C 1 -C 1 0 alkoxy)-; m is 0-2; n is 0-2; and p is 1-5. 48. A method of treating rheumatoid arthritis, asthma, allergies, adult respiratory syndrome, organ transplantation rejection, septic shock, psoriasis, contact dermatitis, osteoporosis, osteoarthritis, tumor metastasis, diabetic retinopathy, inflammatory conditions and inflammatory bowel disease, comprising administering to a host in need of such treatment a t erapeutically effective amount of a compound of Claim 47. 49. A pharmaceutical composition for intranasal administration, said composition comprising a therapeutically effective amount of a compound of Claim 1- 2S or 45-47, a pharmaceutically acceptable excipient, and water. 50. A method of administering a compound of Claim 1- 28 or 45-47, said method comprising intranasaily administering, to a patient in need of such treatment, a therapeutically effective amount of a pharmaceutical composition containing said compound. 51. A compound of Claim 35 wherein the pharmaceutically acceptable salt form is selected from: hydrochloride, benzenesulfonate, methanesulfonate, or para-toluenesuifonate. 52. A prodrug ester of a compound of Claim 3 " , wherein the pharmaceutically acceptable salt form is selected from: acetate, methanesulfonate, hydrochloride, benzenesulfonate, or para-toiuenesulfonate.

Inventors: BATT DOUGLAS GUY, CAIN GARY AVONN, DEGRADO WILLIAM FRANK, HUSSAIN MUNIR ALWAN, MOUSA SHAKER AHMED, OLSON RICHARD ERIC, PINTO DONALD, SIELECKI-DZURDZ THAIS MOTRIA, WITYAK JOHN, XUE CHU-BIAO, BATT, DOUGLAS, GUY, CAIN, GARY, AVONN, DEGRADO, WILLIAM, FRANK, HUSSAIN, MUNIR, ALWAN, MOUSA, SHAKER, AHMED, OLSON, RICHARD, ERIC, PINTO, DONALD, SIELECKI-DZURDZ, THAIS, MOTRIA, WITYAK, JOHN, XUE, CHU-BIAO
Applicants: DU PONT MERCK PHARMA, THE DU PONT MERCK PHARMACEUTICAL COMPANY
Application year: 1996
Main classification: C07D261
IPC codes: A61K31, A61K45, A61P1, A61P3, A61P7, A61P9, A61P11, A61P17, A61P19, A61P27, A61P29, A61P31, A61P35, A61P37, A61P43, C07D261, C07D413, C07D498