SUBSTITUTED PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MODULATORS OF ACETYLCHOLINE RECEPTORS

Abstract: In accordance with the present invention, there are provided compounds having the structure (I), wherein: A, B, N< alpha >, R< alpha >, Z, R<2>, R<4>, R<5> and R<6> are defined as in the description. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists, antagonists or allosteric modulators of acetylcholine receptors, and are useful for a variety of therapeutic applications, such as the treatment of Alzheimer's disease and other disorders involving memory loss and/or dementia (including AIDS dementia); disorders of attention and focus (such as attention deficit disorders); disorders of extrapyramidal motor function such as Parkinson's disease, Huntington's disease, Gilles de la Tourette syndrome and tardive dyskinesia; mood and emotional disorders such as depression, panic, anxiety and psychosis; substance abuse including withdrawal syndromes and substitution therapy; neuroendocrine disorders and dysregulation of food intake, including bulimia and anorexia; disorders of nociception and control of pain; autonomic disorders including dysfunction of gastrointestinal motility and function such as inflammatory bowel disease, irritable bowels syndrome, diarrhea, constipation, gastric acid secretion and ulcers; pheochromocytoma; cardiovascular dysfunction including hypertension and cardia arrhythmias, comedication in surgical procedures, and the like.

Description: SUBSTITUTED PYRIDINE DERIVATIVES. THEIR PREPARATION AND THEIR USE AS MODU¬ LATORS OF ACETYLCHOLINE RECEPTORS The present invention relates to novel compounds which are capable of modulating acetylcholine receptors. Invention compounds are useful, for example, for treatment of dysfunction of the central or autonomic nervous systems including dementia, cognitive disorders, neurodegenerative disorders, extrapyramidal disorders, convulsive disorders, cardiovascular disorders, endocrine disorders, pain, gastrointestinal disorders, eating disorders, affective disorders, and drug abuse. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses therefor. BACKGROUND OF THE INVENTION By modulation of neurotransmitter release (including dopamine, norepinephrine, acetylcholine and serotonin) from different brain regions, acetylcholine receptors are involved in the modulation of neuroendocrine function, respiration, mood, motor control and function, focus and attention, concentration, memory and cognition, and the mechanisms of substance abuse. Ligands for acetylcholine receptors have been demonstrated to have effects on attention, cognition, appetite, substance abuse, memory, extrapyramidal function, cardiovascular function, pain and gastrointestinal motility and function. The distribution of acetylcholine receptors that bind nicotine, i.e., nicotinic acetylcholine receptors, is widespread in the brain, including the basal ganglia, limbic system, cerebral cortex and mid- and hind-brain nuclei. In the periphery, the distribution includes muscle, autonomic ganglia, the gastrointestinal tract and the cardiovascular system. Acetylcholine receptors have been shown to be decreased, inter alia , in the brains of patients suffering from Alzheimer's disease or Parkinson's disease, diseases associated with dementia, motor dysfunction and cognitive impairment. Such correlations between acetylcholine receptors and nervous system disorders suggest that compounds that modulate acetylcholine receptors will have beneficial therapeutic effects for many human nervous system disorders. Thus, there is a continuing need for compounds which can selectively modulate the activity of acetylcholine receptors. In response to such need, the present invention provides a new family of compounds which modulate acetylcholine receptors. BRIEF DESCRIPTION OF THE INVENTION In accordance with the present invention, we have discovered that the class of pyridine compounds defined herein are modulators of acetylcholine receptors. The compounds of the present invention are capable of displacing one or more acetylcholine receptor ligands, e.g., H-nicotine, from mammalian cerebral membrane binding sites. Invention compounds may act as agonists, partial agonists, antagonists or allosteric modulators of acetylcholine receptors. Therapeutic indications for compounds with activity at acetylcholine receptors include diseases of the central nervous system such as Alzheimer's disease and other disorders involving memory loss and/or dementia (including AIDS dementia) ; cognitive dysfunction (including disorders of attention, focus and concentration) , disorders of extrapyramidal motor function such as Parkinson's disease, progressive supramuscular palsy, Huntington's disease, Gilles de la Tourette syndrome and tardive dyskinesia; mood and emotional disorders such as depression, panic, anxiety and psychosis; substance abuse including withdrawal syndromes and substitution therapy; neuroendocrine disorders and dysregulation of food intake, including bule ia and anorexia; disorders of nociception and control of pain; autonomic disorders including dysfunction of gastrointestinal motility and function such as inflammatory bowel disease, irritable bowel syndrome, diarrhea, constipation, gastric acid secretion and ulcers; pheochromocytoma; cardiovascular dysfunction including hypertension and cardia arrhythmias, as well as co-medication uses in surgical applications. DETAILED DESCRIPTION OF THE INVENTION In accordance with the present invention, there are provided compounds having the structure (Formula I) : wherein: A is a 1, 2, 3, 4, 5 or 6 atom bridging species linking C of the pyridine ring with N β , wherein A is selected from a straight chain or branched chain alkylene moiety having up to six atoms in the backbone thereof, or a substituted alkylene moiety, a straight chain or branched chain alkenylene moiety having up to six atoms in the backbone thereof, or a substituted alkenylene moiety, an alkynylene moiety having up to six atoms in the backbone thereof, or a substituted alkynylene moiety, -0-, -C(O)-, -C(S)-, -S-, -S(O)- and/or -S(0) 2 -containing alkylene moiety; provided, however, that any heteroatom contained in A is separated from N α by at least three carbon atoms; and further provided that when A is a -C(0)- or -C(S)- containing alkylene moiety, at least one methylene unit intervenes between the -C(0)- or -C(S)- moiety of A and N α ; and further provided that N α is not conjugated with an alkenyl or alkynyl moiety, wherein A and B can optionally combine to form a monocyclic ring containing A, N β and B, wherein at least one methylene unit intervenes between such ring and C of the pyridine ring; B is a 1, 2, 3 or 4 atom bridging species linking N β with Z, wherein B is selected from a straight chain or branched chain alkylene moiety having up to four atoms in the backbone thereof, or a substituted alkylene moiety, a straight chain or branched chain alkenylene moiety having up to four atoms in the backbone thereof, or a substituted alkenylene moiety, an alkynylene moiety having up to four atoms in the backbone thereof, or a substituted alkynylene moiety, -0-, -C(O)-, -C(S)-, -N*(R , -S-, -S(O)- and/or -S(O)-.-containing alkylene moiety, wherein K is hydrogen or a lower alkyl moiety; provided, however, that any heteroatom contained in B is separated from N° by at least 2 carbon atoms, and further provided that when B is a -C(O)- or -C(S)- containing alkylene moiety, at least one methylene unit intervenes between the -C(O)- or -C(S)- moiety and N β ; and further provided that N β is not conjugated with an alkenyl or alkynyl moiety, and wherein B and R β can optionally combine to form a monocyclic ring containing B, R β and N β ; Z is selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, hydroxyalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic, trifluoromethyl, cyano, cyanomethyl, carboxyl, carbamate, sulfonyl, sulfonamide, aryloxyalkyl, or -0R Z , wherein R z is hydrogen, lower alkyl or aryl, or Z is not present when A and B cooperate to form a ring containing A, N β and B, or when R „« and B cooperate to form a ring containing B, R a and N a ; R ,α is selected from hydrogen or lower alkyl; and ? L. ~ ( R , R , R and R are each independently selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic, trifluoromethyl, halogen, cyano, nitro; -S(0)R', -S(0) 2 R', -S(0) 2 OR' or -S(0) 2 NHR', wherein each R' is independently hydrogen, lower alkyl, alkenyl, alkynyl or aryl; provided, however, that when R 2, R4, R5 or R is -S(0)R', R' is not hydrogen; and further provided that when R' is alkenyl or alkynyl, the site of unsaturation is not conjugated with a heteroatom; -C(0)R", wherein R" is selected from 5 hydrogen, alkyl, substituted alkyl, alkoxy, alkylamino, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, aryloxy, arylamino, alkylaryl, substituted alkylaryl, arylalkyl, 10 substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic or trifluoromethyl, provided, however, that the carbonyl 15 functionality is not conjugated with an alkenyl or alkynyl functionality; -OR' ' • or -NR' ' '-., wherein each R* ' • is independently selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted 20 cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, 25 arylalkynyl, substituted arylalkynyl, aroyl, substituted aroyl, heterocyclic, substituted heterocyclic, acyl, trifluoromethyl, alkylsulfonyl or arylsulfonyl, provided, however, that the -OR • • ' or -NR' • ' 2 30 functionality is not conjugated with an alkenyl or alkynyl functionality; -SR' ' ' ' , wherein R' ' ' ' is selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted 35 alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic or trifluoromethyl, provided, however, that the -SR' ' ' ' functionality is not conjugated with an alkenyl or alkynyl functionality; or -SiR* ' ' • ' 3 , wherein R' ' • ' ' is selected from alkyl or aryl. Specifically excluded from the above definition of compounds embraced by Formula I are compounds wherein A is -CH=CH-(CH 2 ) 1 . 5 -CH 2 -, B is alkyl, Z is H or absent, R β is p C i H, and each of R , R , R and R are independently alkyl or halo; compounds wherein A is -(CH^. j -, B and R β combine to form a B, R a , N σ ring such that B and R a together are C 4 R 8 or C 5 R 10 , wherein R is hydrogen or alkyl, and Z is absent; compounds wherein A is -C(0)-(CH 2 ).,_ 5 -, B is alkyl, Z is absent or H, R β is H or alkyl, and each of R 2 , R 4 , R 5 and R 6 are alkyl or halo; compounds wherein A is -CH 2 -, B is -CH 2 - or -CH 2 -CH 2 -, Z is H, 1 is -CH 3 or -CH 2 -CH 3 , and each of R , R , R and R are hydrogen; compounds wherein A is -CH 2 -, B is -CH 2 -CH(CH 3 )-CH 2 -R, wherein R is para-tertiarybutylphenyl, Z is absent, R a is CH 3 or butyl, and each of R 2 , R 4 , R and R are hydrogen; compounds wherein A is -CH 2 -(CHR) n , wherein R is H or alkyl and n = 0 or 1, B is -(CH 2 ) n -CHR-CH(X)-, wherein R is H, methyl or ethyl, X is phenyl or substituted aryl (substitution selected from halogen, alkyl or alkoxy) , and n = 0 or 1, Z is phenyl or substituted aryl (substitution selected from halogen, alkyl or alkoxy) , R a is H or alkyl, and each of R , R , R and R are selected from hydrogen, alkyl or alkenyl; compounds wherein A is -CH(CH 3 )-, B is -CH 2 -, -CH 2 -C 6 H- or -CH 2 -C 10 H 6 -, Z is hydrogen, -C 6 H 5 , or -C 10 H 7 , R a is CH 3 , and each of R 2 , R 4 , R 5 and R are hydrogen; compounds wherein A is -CH(CH 3 )-, B is -(CH 2 )-, Z is hydrogen, R a is hydrogen, and each of R2, R4, R and R are hydrogen; compounds wherein A is -CH(CH 3 )-, B is -CH 2 -CH 2 -[2,3-(OR) 2 C 6 H 3 ] , wherein R is methyl or benzyl. and R a is hydrogen, or B and R a combine to form a B, R a , N a ring such that B and R a together are -C(=CH 2 )-[1,2-(3,4(OR) 2 benzo]-CH 2 CH 2 -, wherein R is methyl or benzyl, Z in all instances is absent, and each of R 2, R4, R5 and R are hydrogen; as well as compounds wherein A is -CH(CH 3 )- or -CH 2 -CH 2 -CH 2 -, B is -CH 2 -CH 2 -CH(C 6 H 5 )- or -CH(CH 3 )-C 6 H 5 , Z is phenyl or absent, R β is hydrogen, and each of R are hydrogen. As employed herein, "lower alkyl" refers to straight or branched chain alkyl radicals having in the range of about 1 up to 4 carbon atoms; "alkyl" refers to straight or branched chain alkyl radicals having in the range of about 1 up to 12 carbon atoms; "substituted alkyl" refers to alkyl radicals further bearing one or more substituents such as hydroxy, alkoxy (of a lower alkyl group) , mercapto (of a lower alkyl group) , aryl, heterocyclic, halogen, trifluoromethyl, cyano, nitro, a ino, carboxyl, carbamate, sulfonyl, sulfonamide, and the like; "cycloalkyl" refers to cyclic ring-containing radicals containing in the range of about 3 up to 8 carbon atoms, and "substituted cycloalkyl" refers to cycloalkyl radicals further bearing one or more substituents as set forth above; "alkenyl" refers to straight or branched chain hydrocarbyl radicals having at least one carbon-carbon double bond, and having in the range of about 2 up to 12 carbon atoms (with radicals having in the range of about 2 up to 6 carbon atoms presently being preferred) , and "substituted alkenyl" refers to alkenyl radicals further bearing one or more substituents as set forth above; "alkynyl" refers to straight or branched chain hydrocarbyl radicals having at least one carbon-carbon triple bond, and having in the range of about 2 up to 12 carbon atoms (with radicals having in the range of about 2 up to 6 carbon atoms presently being preferred) , and "substituted alkynyl" refers to alkynyl radicals further bearing one or more substituents as set forth above; "aryl" refers to aromatic radicals having in the range of 6 up to 14 carbon atoms and "substituted aryl" refers to aryl radicals further bearing one or more substituents as set forth above; "alkylaryl" refers to alkyl-substituted aryl radicals and "substituted alkylaryl" refers to alkylaryl radicals further bearing one or more substituents as set forth above; "arylalkyl" refers to aryl-substituted alkyl radicals and "substituted arylalkyl" refers to arylalkyl radicals further bearing one or more substituents as set forth above; "arylalkenyl" refers to aryl-substituted alkenyl radicals and "substituted arylalkenyl" refers to arylalkenyl radicals further bearing one or more substituents as set forth above; "arylalkynyl" refers to aryl-substituted alkynyl radicals and "substituted arylalkynyl" refers to arylalkynyl radicals further bearing one or more substituents as set forth above; "aroyl" refers to aryl-carbonyl species such as benzoyl and "substituted aroyl" refers to aroyl radicals further bearing one or more substituents as set forth above; "heterocyclic" refers to cyclic (i.e., ring- containing) radicals containing one or more heteroatoms (e.g., N, O, S, or the like) as part of the ring structure, and having in the range of 3 up to 14 carbon atoms and "substituted heterocyclic" refers to heterocyclic radicals further bearing one or more substituents as set forth above; "acyl" refers to alkyl-carbonyl species; and "halogen" refers to fluoride, chloride, bromide or iodide radicals. In accordance with the present invention, A is a 1, 2, 3, 4, 5 or 6 atom bridging species which links C of the pyridine ring with N a of the pyridine side chain. A can be selected from straight chain or branched chain alkylene moieties having up to six atoms in the backbone thereof, or substituted alkylene moieties, straight chain or branched chain alkenylene moieties having up to six atoms in the backbone thereof, or substituted alkenylene moieties, alkynylene moieties having up to six atoms in the backbone thereof, or substituted alkynylene moieties, -0-, -C(O)-, -C(S)-, -S-, -S(0)- and/or -S(0) 2 -containing alkylene moieties; provided, however, that any heteroatom contained in A is separated from N a by at least three carbon atoms; and further provided that when A is a -C(O)- or -C(S)- containing alkylene moiety, at least one methylene unit intervenes between the -C(0)- or -C(S)- moiety of A and N°; and further provided that N β is not conjugated with an alkenyl or alkynyl moiety. Optionally, A and B can combine to form a onocyclic ring containing A, N a and B, wherein at least one methylene unit intervenes between such ring and C of the pyridine ring. Thus, A can be selected, for example, from: -CR A 2 -, wherein each R is independently selected from hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl or substituted alkynyl; -(cycloalkyl)-, -C(=CXY)-CH 2 -, wherein X and Y are each independently selected from hydrogen, lower alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, hydroxyalkyl, halogen, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, heterocyclic, substituted heterocyclic, aryloxyalkyl, or -OR AA, wherein RAA is lower alkyl or aryl, and the like. Preferably, when A is -C(=CXY)-CH 2 -, X and Y are not both -OR AA. Presently preferred compounds are those wherein A is -CH 2 -, -CH(CH 3 )-, -C(CH 3 ) 2 -, -CH 2 CH 2 -, -CH 2 CH(CH 3 )-, -(spirocyclopropyl)-, -CH=CH-CH 2 -CH 2 -, and the like. Especially preferred compounds of the invention are those wherein A is selected from -CH 2 - or -CH(CH 3 )-. Further in accordance with the present invention, B is a 1, 2, 3 or 4 atom bridging species which links N a of the pyridine side chain with the terminal group of the side chain, Z. B can be selected from straight chain or branched chain alkylene moieties having up to four atoms in the backbone thereof, or substituted alkylene moieties, straight chain or branched chain alkenylene moieties having up to four atoms in the backbone thereof, or substituted alkenylene moieties, alkynylene moieties having up to four atoms in the backbone thereof, or substituted alkynylene moieties, -0-, -C(O)-, -C(S)-, -ϊ (R)-, -S-, -S(O)- and/or -S(0) 2 -containing alkylene moieties, wherein K is hydrogen or a lower alkyl moiety; provided, however, that any heteroatom contained in B is separated from N a by at least 2 carbon atoms, and further provided that when B is a -C(O)- or -C(S)- containing alkylene moiety, at least one methylene unit intervenes between the -C(O)- or -C(S)- moiety and N a ; and further provided that N a is not conjugated with an alkenyl or alkynyl moiety. Optionally, B and A can combine to form a monocyclic ring containing A, N a and B, wherein at least one methylene unit intervenes between such ring and the pyridine ring. As yet another option, B and R a can combine to form a monocyclic ring containing B, R a and N a . Thus, B can be selected, for example, from -CH 2 -, -CH 2 CH 2 -, -CH 2 CH 2 CH 2 -, -CH(CH 3 )-, -(spirocycloalkyl)-, -CH 2 -CH=C(X)- (wherein X is as defined above), -CH 2 -C≡C-, -CH 2 CH 2 -C(0)-, and the like. Presently preferred compounds of the invention are those wherein B is -CH 2 -, -CH 2 CH 2 -, -CH 2 CH 2 CH 2 -, -CH(CH 3 )-, -(spirocyclopropyl)-, -CH 2 -CH=C(X)- (wherein X is H or lower alkyl), -CH 2 -C≡C- or -CH 2 CH 2 -C(0)-, with -CH 2 - presently most preferred. In accordance with one embodiment of the present invention, A and B can combine to form a ring containing A, N a and B, wherein at least one methylene unit intervenes between such ring and the pyridine ring. Examples of such bridging groups include -0-CH 2 CH(CH 2 ) n -, wherein n falls in the range of 1 up to 5, wherein n being 3 or 4 is presently preferred. As yet another alternative embodiment of the present invention, B and R a can combine to form a ring containing B, R a and N α . Examples of such combination include -CH 2 CH 2 CH 2 -, -CH 2 CH 2 CH 2 CH 2 -, -CH 2 CH 2 CH 2 CH 2 CH 2 -, and the like. In accordance with the present invention, Z is selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, hydroxyalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic, trifluoromethyl, cyano, cyanomethyl, carboxyl, carbamate, sulfonyl, sulfonamide, aryloxyalkyl, or -OR , wherein R is hydrogen, lower alkyl or aryl. Z is not present, however, when A and B cooperate to form a ring containing A, N a and B, or when R a and B cooperate to form a ring containing B, R a and N a . In accordance with the present invention, R a is selected from hydrogen or lower alkyl. . 2 4 In accordance with the present invention, R , R , R and R are each independently selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic, trifluoromethyl, halogen, cyano, nitro; -S(0)R', -S(0) 2 R', -S(0) 2 0R' or -S(0) 2 NHR*, wherein each R' is independently hydrogen, lower alkyl, alkenyl, alkynyl or aryl; provided, however, that when R 2, R4, R5 or R is -S(0)R', R' is not hydrogen; and further provided that when R' is alkenyl or alkynyl, the site of unsaturation is not conjugated with a heteroatom; -C(0)R", wherein R" is selected from hydrogen, alkyl, substituted alkyl, alkoxy, alkylamino, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, aryloxy, aryla ino, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic or trifluoromethyl, provided, however, that the carbonyl functionality is not conjugated with an alkenyl or alkynyl functionality; -OR' ' ' or -NR' • ' 2 , wherein each R' • • is independently selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, aroyl, substituted aroyl, heterocyclic, substituted heterocyclic, acyl, trifluoromethyl, alkylsulfonyl or arylsulfonyl, provided, however, that the -OR' ' ' or -NR 1 ' ' 2 functionality is not conjugated with an alkenyl or alkynyl functionality; -SR' ' ' ' , wherein R' ' ' ' is selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic or trifluoromethyl, provided, however, that the -SR' ' ' ' functionality is not conjugated with an alkenyl or alkynyl functionality; or -SiR' ' ' ' ' 3 , wherein R 1 ' ' ' ' is selected from alkyl or aryl. In accordance with a preferred aspect of the present invention, R is alkynyl or substituted alkynyl having the structure: 5 ' - C ≡ C - R 5< wherein R is selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, heterocyclic, substituted heterocyclic, trifluoromethyl, halogen, cyano, nitro; -S(0)R', -S(0) 2 R' or -S(0) 2 NHR' , wherein each R 1 is as defined above, provided, however, that when R , R 4 or R 6 is -S(0)R', R' is not hydrogen, 2 4 alkenyl or alkynyl, and provided that when R , R or R is -S(0) 2 NHR', R' is not alkenyl or alkynyl; -C(0)R", wherein R" is selected from hydrogen, alkyl, substituted alkyl, alkoxy, alkylamino, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, aryloxy, arylaraino, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, heterocyclic, substituted heterocyclic or trifluoromethyl, provided, however, that the carbonyl functionality is not conjugated with an alkenyl or alkynyl functionality; -OR' ' ' , wherein R' ' ' is selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, aroyl, substituted aroyl, heterocyclic, substituted heterocyclic, acyl, trifluoromethyl, alkylsulfonyl or arylsulfonyl, provided, however, that the -OR' ' ' functionality is not conjugated with an alkenyl or alkynyl functionality; -NR' ' ' 2 , wherein each R' ' * is independently as defined above, or each R' ' ' and the N to which they are attached can cooperate to form a 4-, 5-, 6- or 7-membered ring; provided, however, that the -NR' ' ' 2 functionality is not conjugated with an alkenyl or alkynyl functionality; -SR' ' ' ' , wherein R' ' ' ' is selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, heterocyclic, substituted heterocyclic or trifluoromethyl, provided, however, that the -SR' ' ' ' functionality is not conjugated with an alkenyl or alkynyl functionality; or -SiR' ' ' * ' 3 , wherein R* * * ' • is selected from alkyl or aryl, and the like. In addition, R 5' can also be alkylene, substituted alkylene, arylene, substituted arylene, and the like, so that the resulting compound is a polyfunctional species, bearing two or more of the substituted pyridyl structures contemplated by structure I. Thus, R serves as a bridge or linking moiety to couple two or more of the substituted pyridyl structures contemplated by structure I in a single compoun . Presently preferred groups include hydrogen, methyl, ethyl, propyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, methoxymethyl, 2-hydroxy-2-isopropyl, dimethylaminomethyl, phenyl, substituted phenyl (e.g., 3-hydroxyphenyl, 3-hydroxy-4-substituted phenyl (wherein the substitution is methyl, chloro or fluoro) , 4-hydroxyphenyl, 3-substituted-4-hydroxyphenyl (wherein the substitution is methyl, chloro or fluoro) , amides (-CH 2 -NH-C(0)-R, wherein R is selected from hydrogen or lower alkyl) , sulfonamides (-CH 2 -NH-S0 2 -R, wherein R is as defined above) , and the like. In accordance with another preferred aspect of the present invention, R is an optionally substituted 3- or 4-hydroxyphenyl species. Thus, 3-hydroxyphenyl moieties, as well as 3-hydroxy-4-substituted phenyl moieties are preferred herein, wherein the optional substitution is methyl, chloro or fluoro. In addition, 4-hydroxyphenyl moieties, as well as 3-substituted-4-hydroxyphenyl moieties are also preferred herein, wherein the optional substitution is methyl, chloro or fluoro. Presently pre erred compounds of the invention are those wherein R 2 is hydrogen; wherei.n R4 i.s hydrogen, aryl, alkoxy or aryloxy; wherein R is selected from alkynyl (with ethynyl being especially preferred) , aryl, substituted aryl (wherein substituents on the aryl ring are independently selected from one or more of bromine, chlorine, fluorine, phenyl, methoxy, hydroxy, mercaptomethyl and trifluoromethyl substituents being especially preferred) , trialkylsilyl, arylalkyl, arylalkenyl or arylalkynyl; wherein R is selected from hydrogen, chlorine, amino, alkyl or alkoxy (with hydrogen, methyl or methoxy being especially preferred) ; and wherein R a is hydrogen or methyl. Particularly preferred compounds of the invention include the compound wherein A = -CH 2 - or -CH 2 CH 2 -, B and R α combined = -CH 2 CH 2 CH 2 - or -CH 2 CH 2 CH 2 CH 2 -, Z is not present (due to the linkage of B with R) , R 2 , R 4 and R 6 = H, and R 5 is selected from hydrogen, phenyl, parahydroxyphenyl, 3-chloro-4-hydroxyphenyl, or ethynyl; as well as compounds wherein A is selected from -CH 2 -, -CH(CH 3 )-, -C(CH 3 ) 2 -, or -(spirocyclopropyl)-, B = -CH 2 ~, Z = hydrogen, R a = H or methyl and R , R , R and R = H; as well as compounds wherein A = -C(=CXY)CH 2 - (wherein X and Y are each independently selected from hydrogen, lower alkyl, hydroxyalkyl, fluoro or aryl) , B and R a combined = -CH 2 CH 2 CH 2 CH 2 -, Z = not present, and R 2 , R 4 , R 5 and R 6 = hydrogen. Additional preferred compounds of the invention include those wherein A = -CH 2 -, B = -CH 2 CH 2 -, -CH 2 CH 2 CH 2 - or -CH 2 CH 2 -C(0)-, Z = phenyl, substituted phenyl, furanyl or substituted furanyl, imidazolyl, or 3,4-benzopyrrolidine, R β = hydrogen or methyl, and R , R , R , and R = hydrogen; as well as compounds wherein A and B combined = -0-CH 2 CHCH 2 CH 2 CH 2 -, thereby forming a ring including A, N a and B, Z = not present, R a = methyl, and R , R , R , and R are independently selected from the group set forth above, wwiitthh tthhee pprroovviissoo tthhaatt RR ,, R , R , and R are not hydrogen, alkyl, alkoxy or halogen. Still further preferred compounds contemplated for use in the practice of the invention include those wherein A = -CH 2 - or -CH 2 CH(CH 3 )-, B = -CH 2 -CsC-, Z = hydrogen, R a = methyl, and R , R , R , and R = hydrogen; as well as those wherein A = -CH 2 -, B = -CH 2 -CH=C(X) - , wherein X is selected from hydrogen, lower alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, hydroxyalkyl, 778halogen (especially fluoro) , aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, heterocyclic, substituted heterocyclic, aryloxyalkyl, or -OR , wherein R is lower alkyl or aryl, Z = lower alkyl, hydroxyalkyl, trifluoromethyl, cyano, cyanomethyl, carboxyl, carbamate, sulfonyl, sulfonamide, aryl, aryloxyalkyl, or -OR , wherein R is lower alkyl or aryl, R a = methyl, and R 2 , R 4 , R 5 , and R 6 = hydrogen. It is preferred that when X is -ORx, Z i.s not -ORZ. Still further preferred compounds of the invention include those wherein A = -CH 2 -, B = -CH 2 CH 2 -C(0)- or -CH 2 CH 2 -C(0)-NH-, Z = phenyl or substituted phenyl, R a = methyl, and R 2 , R 4 , R 5 , and R 6 = hydrogen; as well as compounds wherein A = -CH 2 - or -CH(CH 3 )-, B = -CH 2 -, -CH(CH 3 )-, or -(cyclopropyl)-, Z = hydrogen, R a = hydrogen or methyl, and R , R , R , and R = hydrogen. Additional preferred compounds of the invention include those wherein A = -CH=CH-CH 2 -CH 2 -, B = -CH 2 -, Z = hydrogen, R a = hydrogen, R 5 = - C S C - R ', wherein R ' is as defined above (with hydrogen, methyl, ethyl, propyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, methoxymethyl, 2-hydroxy-2-isopropyl, dimethylaminomethyl, phenyl, substituted phenyl (e.g., 3-hydroxyphenyl, 3-hydroxy-4-substituted phenyl (wherein the substitution is methyl, chloro or fluoro) , 4-hydroxyphenyl, 3-substituted-4-hydroxyphenyl (wherein the substitution is methyl, chloro or fluoro) , amides (-CH 2 -NH-C(0)-R, wherein R is selected from hydrogen or lower alkyl) and sulfonamides (-CH 2 -NH-S0 2 -R, wherein R is as defined above) preferred) or R = 3-hydroxyphenyl, 3-hydroxy-4-substituted phenyl (wherein the optional substitution is methyl, chloro or fluoro) , 4-hydroxyphenyl, or 3-substituted- 4-hydroxyphenyl (wherein the optional substitution is methyl, chloro or fluoro) , and R 2 , R , and R = hydrogen; as well as compounds wherein A and B combined = -0-CH 2 CH(CH 2 ) n -, wherein n is 3 or 4, Z = hydrogen, R a = hydrogen, R = - C s C - R 5', wherein R5' is as defined above (with hydrogen, methyl, ethyl, propyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, methoxymethyl, 2-hydroxy-2- isopropyl, dimethylaminomethyl, phenyl, substituted phenyl (e.g., 3-hydroxyphenyl, 3-hydroxy-4-substituted phenyl (wherein the substitution is methyl, chloro or fluoro) , 4-hydroxyphenyl, 3-substituted-4-hydroxyphenyl (wherein the substitution is methyl, chloro or fluoro) , amides (-CH 2 -NH-C(0)-R, wherein R is selected from hydrogen or lower alkyl) and sulfonamides (-CH 2 -NH-S0 2 -R, wherein R is as defined above) preferred) or R = 3-hydroxyphenyl, 3-hydroxy-4-substituted phenyl (wherein the optional substitution is methyl, chloro or fluoro) , 4-hydroxyphenyl, or 3-substituted-4-hydroxyphenyl (wherein the optional substitution is methyl, chloro or fluoro) , and R 2, R4, and R = hydrogen. Invention compounds have affinity for acetylcholine receptors. As employed herein, the term "acetylcholine receptor" refers to both nicotinic and muscarinic acetylcholine receptors. Affinity of invention compounds for such receptors can be demonstrated in a variety of ways, e.g., via competitive radioligand binding experiments in which the test compounds displace isotopically labelled ligands (such as nicotine, cytisine, methylcarbamylcholine, quinuclidinyl benzilate, and the like) from binding sites in mammalian cerebral membranes. Furthermore, the binding of compounds to acetylcholine receptors can be evaluated as a functional response. For example, the activity of invention compounds can be evaluated employing functional assays based on recombinant neuronal acetylcholine receptor expression systems (see, for example, Williams et al., Drug News & Perspectives 2:205-223 (1994)). Test compounds can also be evaluated for their ability to modulate the release of neurotransmitters (e.g., dopamine, norepinephrine, and the like) from rat brain slices (e.g., striatum, hippocampus, and the like) . See Examples 14 and 15 for further detail on such techniques. Moreover, test compounds can also be evaluated by way of behavioral studies employing animal models of various CNS, autonomic and cardiovascular disorders (see, for example, D'Amour and Smith, J . Pharmacol . Exp. Ther. 72.:74-79 (1941) and Iwa oto, J. Pharmacol . Exp . Ther . 251:412-421 (1989) for animal models of pain; Klockgether and Turski, Ann . Neurol . 28:539-546 (1990) , Colpaert, F. , Neurophar acology 26: 1431-1440 (1987) , Ungerstedt and Arbuthknott, Brain Res . 24:485-493 (1970) , Von Voigtlander and Moore, Neuropharmacology 11:451-462 (1973), Ungerstedt et al., Adv . Neurol . 2:257- 279 (1973) , Albanese et al., Neuroεcience 55:823-832 (1993), Janson et al., Clin . Investig . .70:232-238 (1992), Sundstrom et al., Brain Res . 528:181-188 (1990), Sershen et al., Pharmacol . Biochem . Behav . 18:299-303 (1987) for animal models of Parkinson's disease; Williams et al., Gastroenterology £4:611-621 (1988), Miyata et al., J. Pharmacol . Exp . Ther. 261:297-303 (1992), Yamada et al., Jpn . J . Pharmacol . 58 (Suppl.. :131 (1992) for animal models of irritable bowel syndrome; Coyle et al., NeuroJbe av. Toxicol . Tetatol . .5:617-624 (1983), Schartz et al., Science 219:316-318 (1983) for animal models of Huntington's disease; Clow et al., Euro . J . Pharmacol . 57:365-375 (1979), Christensen et al., Psychoparmacol . 4.8:1-6 (1976), Rupniak et al., Psychopharmacol . 2^:226-230 (1983), Waddington et al., Science 220:530-532 (1983) for animal models of tardive dyskinesia; Emerich et al., Pharmacol . Biochem . Behav. __8 :875-880 (1991) for animal models of Gilles de la Tourette's syndrome; Brioni et al., Eur. J. Pharmacol . 238:1-8 (1993), Pellow et al., J. Neurosci . Meth . 14.:149 (1985) for animal models of anxiety; and Estrella et al., Br. J . Pharmacol 92:759-768 (1988) for the rat phrenic nerve model which indicates whether a compound has muscle effects that may be useful in treating neuromuscular disorders) . Those of skill in the art recognize that invention compounds may contain one or more chiral centers, and thus can exist as racemic mixtures. For many applications, it is preferred to carry out stereoselective syntheses and/or to subject the reaction product to appropriate purification steps so as to produce substantially optically pure materials. Suitable stereoselective synthetic procedures for producing optically pure materials are well known in the art, as are procedures for purifying racemic mixtures into optically pure fractions. In accordance with still another embodiment of the present invention, there are provided methods for the preparation of pyridine compounds as described above. For example, many of the pyridine compounds described above can be prepared using synthetic chemistry techniques well known in the art from the acyl pyridine precursor of Formula II as outlined in Scheme I. Scheme I Step A II Condensation III Step B III IV Step C IV Alkylation ? In the above scheme, R , R , R , R , R°, B and Z are as defined above, and R is selected from hydrogen, alkyl, alkoxy (of a lower alkyl group), mercapto (of a lower alkyl group) , aryl, heterocyclic, trifluoromethyl, cyano, carboxyl, carbamate, sulfonyl, sulfonamide, and the like. In step A of Scheme I, for yl or acyl pyridine of Formula II is coupled with an amine having the general formula N a H 2 BZ to produce an imine of Formula III. This coupling reaction is promoted by a suitable catalyst, such as, for example, titanium tetrachloride , paratoluenesulfonic acid, and the like. The presently preferred catalyst for use in the practice of the present invention is titanium tetrachloride. The above-described coupling reaction is typically carried out in aprotic solvent, such as, for example, tetrahydrofuran (THF) , diethyl ether, tert-butyl methyl ether, l,2-dimethoxyethane, toluene, and the like. Presently preferred solvents for use in the practice of the present invention are THF and 1,2-dimethoxyethane. The coupling reaction can be carried out over a wide range of temperatures. Typically reaction temperatures fall in the range of about -78°C up to reflux. Temperatures in the range of about -78°C up to ambient are presently preferred. Reaction times required to effect the desired coupling reaction can vary widely, typically falling in the range of about 15 minutes up to about 24 hours. Preferred reaction times fall in the range of about 4 up to 12 hours. It is not necessary to purify the product of the above-described coupling reaction (i.e., compound of Formula III), and the resulting reaction product is typically subjected directly to the reduction step described below as step B. In Step B of Scheme I, imine of Formula III is reduced to produce the secondary amine IV. The desired reduction is typically effected by contacting imine with a suitable hydride source (e.g., sodium borohydride, sodium cyanoborohydride, lithium aluminum hydride, sodium triacetoxyborohydride, lithium tri-tert-butoxy aluminum hydride, sodium trimethoxy- borohydride, diisobutylaluminum hydride, formic acid, and the like) or by contacting the imine with hydrogen in the presence of a transition metal catalyst (such as, for example, palladium on carbon, Raney Nickel, platinum oxide, tris(triphenylphosphine)rhodium (I) chloride (i.e., Wilkinson's catalyst) , palladium hydroxide, and the like) . Presently preferred reducing conditions comprise treating imine III with sodium borohydride in a solvent mixture such as methanol/acetic acid, or sodium cyanoborohydride in a suitable solvent system, at a reaction temperature in the range of about -60°C up to about ambient temperature, for in the range of about 1 up to 24 hours. As recognized by those of skill in the art, the selection of reducing agent, reaction time, reaction temperature and reaction media will depend on the specific compound having the Formula III which is being treated. Alternatively, amines of formula IV can be prepared from II in one step by contacting the for yl or acyl pyridine with an amine in the presence of sodium cyanoborohydride and a catalytic amount of acid (e.g. , glacial acetic acid) in a suitable solvent (such as acetonitrile) . Secondary amines of Formula IV can then be recovered from the reaction media by basification, followed by extraction, filtration, and the like. Purification can be achieved by a variety of techniques, such as, for example, chromatography, recrystallization, distillation, and the like. If desired, secondary amines IV can be further converted into acid addition salts. Since secondary amine IV may have a center of asymmetry, reagents for the above-described reduction reaction can be chosen so as to promote selective reduction to produce amine IV which is substantially enriched in one of the possible enantiomers. In some instances, by judicious choice of reducing agents, each of the possible enantiomers can be prepared in high optical purity. For example, chiral borohydride reducing agents can be employed, as described, for example, by Yamada et al. in J. Chem . Soc , Perk . 1 265 (1983), Kawate et al., in Tetrahedron Asym . 3_, 227 (1992), Mathre et al., J. Org. Chem . _5$:2880 (1993), or Cho and Chun in J. Chem . Soc . Perk . 1 3200 (1990). Alternatively, catalytic hydrogenation in the presence of chiral catalyst can be employed, as described, for example, by Kitamura et al., in J. Org . Chem . 59:297 (1994), Burk et al., in Tetrahedron .50:4399 (1994), Burk et al, in J . Am . Chem . Soc . 115:10125 (1993), Willoughby and Buchwald in J. Org . Chem . 58:7627 (1993) , or Willoughby and Buchwald in J " . Am . Chem . Soc . 114:7562 (1992). As yet another alternative, optically pure enantiomers of compounds of Formula I containing a chiral center can be prepared by resolution of a mixture of enantiomers by selective crystallization of a single enantiomer in the presence of an optically pure acid addition salt. Such methods are well known in the art, such as, for example, the preparation of optically pure addition salts with each isomer of tartaric acid, tartaric acid derivatives, and the like. Another method which is widely used in the art involves the preparation of diastereomeric derivatives of racemic amines (e.g., α-methoxy-α-(trifluoromethyl) phenylacetic acid (i.e., Mosher's acid) amide derivatives). The resulting diastereomeric derivatives can then be separated by well known techniques, such as chromatography. The separation of the respective enantiomers of a racemic mixture can be accomplished employing chromatographic techniques which utilize a chiral stationary phase. Examples include chiral gas chromatography (chiral GC) , chiral medium performance liquid chromatography (chiral MPLC) , chiral high performance liquid chromatography (chiral HPLC) , and the like. For compounds of Formula I, where R »α is not hydrogen, alkylation step C of Scheme I is carried out. Those of skill in the art can readily identify suitable N-alkylation reactions suitable for such purpose. For example, secondary amine of Formula IV can be contacted with an aldehyde (e.g., formaldehyde, acetaldehyde, benzaldehyde, and the like) in the presence of a suitable reducing agent (such as the reducing agents described above with reference to Step B) . The substituted amines of Formula I produced by the above-described alkylation/reduction reaction can be isolated and purified employing standard methods which are well known in the art (e.g., extraction, chromatography, distillation, and the like) . A presently preferred technique for recovery of reaction product is extraction of amine I from basified reaction medium with dichloromethane. Alternatively, crude amine can be converted into an acid addition salt (e.g., hydrochloride, hydrobromide, fumarate, tartrate , and the like) , then purified by r eery stallizat ion . Alternative methods for the preparation of compounds of Formula I are depicted in Schemes II and III, which involve reductive amination, either of ketone VII with pyridylamine VI (as illustrated in Scheme II) , or of pyridylketone IX with amine X (as illustrated in Scheme III) . "Scheme II VI VII Reaction Intermediate VIII VIII Reductive Amination Thus, according to Scheme II, ketone VII is coupled with pyridylamine VI under reductive conditions which afford I without the need to isolate the intermediate imine VIII. In Scheme II, the core of ketone VII (i.e., R 9 -C(0)-Q-) represents a particular embodiment of B, as defined above. Thus, R 9 and Q are selected such that the moiety "R 9 -C(0)-Q-" falls within the definition of B as provided above. IX R 4 B — Z Reductive Aminat JOn I I I no <: 6 ^ .c 2 R<-^ ^N 1 ^ \ R 2 Thus, according to Scheme III, pyridylketone IX is coupled with amine X under reductive conditions which afford I without the need to isolate the intermediate imine. In Scheme III, the substituent at C 3 of the pyridine ring of pyridylketone IX (i.e., -Q-C(O)-R) represents a particular embodiment of A, as defined above. Thus, Q and R are selected such that the moiety "-Q-C(0)-R" falls within the definition of A as provided above. The reductive amination coupling reaction referred to in Schemes II and III is well known and can be achieved in a variety of ways. For example, a solution of the appropriate ketone (VII or IX) and amine (VI or X) , respectively, in suitable solvent (e.g., CH 3 OH or acetonitrile) is acidified to a pH of about 3 with suitable acid (e.g., acetic acid), and cooled to about -40°C. After 20 minutes, solid sodium borohydride is added portionwise to the solution. When all of the sodium borohydride has been added, the reaction is allowed to run to completion (over a range of about 30 minutes up to 24 hours, typically for 1-3 hours) . The cooling bath is removed and the temperature of the reaction mixture allowed to rise to room temperature. Aqueous base, such as sodium carbonate, is added to the reaction mixture to increase the pH to about 9-10. Amine product I is then isolated by normal solvent extraction procedures and purified by standard means. In some cases, purification is facilitated by conversion of I to its acid addition salt (e.g., maleate and fumarate addition salts) . A useful alternate reducing agent to sodium borohydride is sodium cyanoborohydride (see Borch, Bernstein and Durst, J". Amer. Chem. Soc . 93:2897 (1971)) . Another versatile reductive amination procedure uses hydrogen as the reducing agent in the presence of a transition metal catalyst, such as Pt0 2 or Pd/C. As readily recognized by those of skill in the art, the choice of reducing agent will often be determined by the presence (or absence) of other functional groups in I. Yet another method for the preparation of compounds of Formula I (specifically compounds wherein A = CH 2 ) is depicted in Scheme IV, involving reaction of carboxypyridine XI with amine X, to form an amide, which can then be reduced to produce pyridylamine XIII, as follows : XI Amide bond formation XII Step B XII Reduction _ XIII Thus, according to Scheme IV, compounds described by Formula I in which A = CH 2 can readily be prepared from a variety of nicotinic acid derivatives (XI) . Referring now to Step A of Scheme IV, amide bond formation between acid XI and amine X can be accomplished by a variety of well-known procedures. For example, the acid functionality of XI can be converted to an acid chloride (for example, by treatment with oxalylchloride) , then the resulting acid chloride is contacted with amine X in a neutral solvent (e.g., THF or CH 2 C1 2 ) , with or without added base. The resulting amide XII can then be purified by standard methods such as chromatography, recrystallization, and the like. Reduction of the amide functionally in XII is typically achieved by the use of a hydride reducing agent, such as, for example, lithium aluminum hydride, diisobutylaluminum hydride, diborane or a diborane complex, and the like. The reaction is typically performed in an aprotic solvent, such as, for example, diethyl ether, THF, hexane, toluene, CH 2 C1 2 , and the like, as well as mixtures thereof. Reaction temperatures vary from about -78°C up to solvent reflux, and reaction times vary from about 15 minutes to 24 hours. The choice of reducing agent, solvent, reaction temperature, and reaction time depends upon the presence and nature of other functional groups which may be present in I. Still another method for the preparation of compounds of Formula I is depicted in Scheme V, involving coupling of hydroxypyridine XIV with hydroxyamine XV, as follows: Scheme V XIV XV Mitsunobu Coupling XVI In Scheme V, the preparation of compounds of Formula I having an oxygen atom bridge between the pyridine ring and the side chain is described. Indeed, the use of the Mitsunobu reaction to prepare 3-oxopyridine derivatives has been described in the patent literature (see Abreo et al., WO 94/08992). In Scheme V, the alcohols XIV and XV are dissolved in a suitable solvent (such as, for example, THF) and then treated with triphenylphosphine and diethyl azodicarboxylate at ambient temperature for about 1-24 hours. The reaction product XVI (which is a specific embodiment of I, wherein the moiety "A" of I is represented by "-0-Q-") can readily be isolated and purified as described above. Yet another method for the preparation of compounds of Formula I, specifically compounds in which an exocyclic olefin is present in A, is depicted in Scheme VI, involving reaction of substituted pyridine XVII with acid XX, to form amide XVIII, which is then reduced to produce pyridylamine XIX, as follows: Scheme VI Step A XVII XX Condensation XVIII Step B XVIII Reduction XIX Alternatively, pyridylamine XIX can be prepared in one step from substituted pyridine XVII by reductive amination of ketone XXI with XVII, as follows: Scheme VII XVII XXI Reductive Amination XIX Thus, Schemes VI and VII provide methodolgy for use in the preparation of compounds of Formula XIX, i.e., compounds of general formula I which contain an exocyclic double bond as part of moiety A. Synthetic methods useful for the preparation of substituted allylamines XVII contemplated for use in the practice of the present invention are known in the art (see, for example, McDonald et al., J . Med . Chem . 28:186 (1985) ; and McDonald et al., Tetrahedron Letters 26:3807 (1985)) . As shown in Schemes VI and VII, conversion of allylamine XVII to Formula I variant XIX can be achieved by the reductive amination procedure discussed above with reference to Schemes II and III (see Scheme VII) or by the two step procedure described above with reference to Scheme IV (see Scheme VI) . Yet another method for the preparation of compounds of Formula I is depicted in Scheme VIII, wherein hydroxypyridine XXII is activated with a suitable activating agent, then the resulting activated compound XXIII is subjected to nucleophilic displacement conditions in the presence of amine X, thereby producing compound I. Scheme VIII Step A Activating agent XXII Step B XXIII In Scheme VIII, starting alcohol XXII is selected such that -A'CH(R)- = A in the final product I. Conversion of XXII to I can be achieved in some cases by a Mitsunobu reaction (as described above with reference to Scheme V) , or, preferably, in two steps incorporating an activation reaction, followed by nucleophilic displacement (assisted by the presence of an activating group "Act") . Suitable activating groups include trifluoroacetate, mesylate, triflate, and the like. Typically, XXII is dissolved in an aprotic solvent such as THF at temperatures from -78°C to ambient temperature, usually in the presence of a suitable base such as trialkylamine, especially triethylamine, or 4- dimethylaminopyridine. The anhydride, or chloride derivative of the activating group (e.g., trifluoracetic anhydride, mesylchloride, and the like) is added slowly to the reaction flask. When the addition is complete, the reaction is allowed to proceed at ambient temperature for about 30 minutes up to 12 hours, typically 1 hour. The resulting activated intermediate XXIII can be isolated and purified, or used directly without purification in the next step. Thus, XXIII is dissolved in an aprotic polar solvent such as acetonitrile and contacted with amine X. Optionally, a base such as K 2 C0 3 or triethylamine is added, which serves to accelerate the reaction. The nucleophilic displacement reaction occurs at about -30°C to 100°C, typically at 25-75°C, and takes from 1-24 hours, typically, 2-8 hours, to reach completion. Product I can then be isolated and purified as described above. It is readily apparent to those skilled in the art that other activating methodologies can be employed to facilitate the above-described conversion. For example, the hydroxy1 group in XXII can be converted to a halogen, preferably bromine or iodine, prior to the displacement reaction. When any one or more of R , R , R or R of compounds of Formula I are reactive substituents (e.g., bromine, iodine, trifluoromethylsulfonyloxy, and the like) , it is possible to further modify such compounds taking advantage of the presence of the reactive functionality. One such modification is shown in Scheme IX. Scheme IX Coupling ->, XXIV In Scheme IX, the starting material employed is a compound of the Formula XXIV (i.e., a compound according to formula I, wherein R is Z ' , wherein Z' is an active functionality which is capable of undergoing a transition metal catalyzed coupling reaction (e.g., bromine, iodine, trifluoromethylsulfonyloxy, and the like) . If R in the desired final product is an aryl or substituted aryl group, such products can be prepared employing well known organometallic procedures, such as, for example, by coupling an arylzinc compound (prepared by reaction of an arylbro ide with an alkyllithium reagent such as n- butyllithium, tert-butyllithium, followed by addition of zinc chloride) with compound of Formula I, wherein R is Z' in the presence of a catalytic amount of a suitable coupling catalyst (e.g., PdCl 2 (PPh 3 ) 2 , and the like) in a suitable solvent such as toluene, dimethylforroamide, THF, and the like. Suitable reaction temperatures fall in the range of about 0°C to 140°C (with temperatures in the range of about 0°C up to 80°C being preferred) , with reaction times in the range of about 4 up to 24 hours. Similarly, coupling procedures can be used to prepare compounds of Formula I in which R , R , R and R are independently alkyl, alkenyl, alkynyl, arylalkyl, alkylaryl, and the like. An alternative method to promote the desired coupling reaction employs organoborane chemistry, wherein arylboronic acids, in the presence of a suitable catalyst (e.g., Pd(Ph 3 ) 4 ) in basic aqueous dimethoxyethane are coupled with compounds of Formula XXIV wherein one or more of R , R , R and R is Z' . The reaction is typically carried out at a temperature in the range of about 40°C up to 150°C (with a temperature in the range of 80°C being preferred) , for a time in the range of about 1 up to 24 hours (with about 8 hours being preferred) . Arylboronic acids are well known in the art and can be readily obtained by those of skill in the art. It is also readily apparent to those of skill in the art that the selection of a particular reaction scheme will be determined in part by the chemical reactivity of the functional groups in I. Many of the compounds encompassed by Formula I may exist as a variety of geometric isomers, racemic isomers or diasteromeric isomers. It is understood that this invention relates to individual isomers as well as mixtures of isomers. When individual isomers are required, numerous well known procedures can be employed to either synthesize the desired isomer in a stereospecific manner, or to separate the isomers at an intermediate or final stage of the synthesis. The starting materials used in Schemes I-IX are either known compounds and/or can readily be made from known compounds employing well known chemical procedures. For example, the pyridine-containing starting materials can be prepared from appropriately substituted derivatives of nicotinic acid, nicotinamide, pyridine-3-acetic acid, and the like. In addition to the above-described synthetic procedures, those of skill in the art have access to numerous other synthetic procedures which can be employed for the preparation of invention compounds. Indeed, the literature is replete with methodologies that can be used for the preparation of starting and/or intermediate compounds which are useful for the preparation of invention compounds (e.g., compounds having formulas II, VI, IX, XI, XIV, XVII, XXII, and the like). Such starting and/or intermediate compounds can then be modified, for example, as described herein, to introduce the necessary substituents to satisfy the requirements of Formula I. In accordance with another embodiment of the present invention, there are provided pharmaceutical compositions comprising pyridine compounds as described above, in combination with pharmaceutically acceptable carriers. Optionally, invention compounds can be converted into non-toxic acid addition salts, depending on the substituents thereon. Thus, the above-described compounds (optionally in combination with pharmaceutically acceptable carriers) can be used in the manufacture of a medicament for modulating the activity of acetylcholine receptors. Pharmaceutically acceptable carriers contemplated for use in the practice of the present invention include carriers suitable for oral, intravenous, subcutaneous, transcutaneous, intramuscular, intracutaneous, inhalation, and the like administration. Administration in the form of creams, lotions, tablets, dispersible powders, granules, syrups, elixirs, sterile aqueous or non-aqueous solutions, suspensions or emulsions, patches, and the like, is contemplated. For the preparation of oral liquids, suitable carriers include emulsions, solutions, suspensions, syrups, and the like, optionally containing additives such as wetting agents, emulsifying and suspending agents, sweetening, flavoring and perfuming agents, and the like. For the preparation of fluids for parenteral administration, suitable carriers include sterile aqueous or non-aqueous solutions, suspensions, or emulsions. Examples of non-aqueous solvents or vehicles are propylene glycol, polyethylene glycol, vegetable oils, such as olive oil and corn oil, gelatin, and injectable organic esters such as ethyl oleate. Such dosage forms may also contain adjuvants such as preserving, wetting, emulsifying, and dispersing agents. They may be sterilized, for example, by filtration through a bacteria-retaining filter, by incorporating sterilizing agents into the compositions, by irradiating the compositions, or by heating the compositions. They can also be manufactured in the form of sterile water, or some other sterile injectable medium immediately before use. Invention compounds can optionally be converted into non-toxic acid addition salts. Such salts are generally prepared by reacting the compounds of this invention with a suitable organic or inorganic acid. Representative salts include the hydrochloride, hydrobromide, sulfate, bisulfate, methanesulfonate, acetate, oxalate, valerate, oleate, laurate, borate, benzoate, lactate, phosphate, tosylate, citrate, maleate, fumarate, succinate, tartrate, napsylate, and the like. Such salts can readily be prepared employing methods well known in the art. In accordance with yet another embodiment of the present invention, there are provided methods of modulating the activity of acetylcholine receptors, said method comprising: contacting cell-associated acetylcholine receptors with a concentration of a pyridine compound as described above sufficient to modulate the activity of said acetylcholine receptors. As employed herein, the phrase "modulating the activity of acetylcholine receptors" refers to a variety of therapeutic applications, such as the treatment of Alzheimer's disease and other disorders involving memory loss and/or dementia (including AIDS dementia) ; cognitive dysfunction (including disorders of attention, focus and concentration) , disorders of extrapyramidal motor function such as Parkinson's disease, progressive supramuscular palsy, Huntington's disease, Gilles de la Tourette syndrome and tardive dyskinesia; mood and emotional disorders such as depression, panic, anxiety and psychosis; substance abuse including withdrawal syndromes and substitution therapy; neuroendocrine disorders and dysregulation of food intake, including bulemia and anorexia; disorders of nociception and control of pain; autonomic disorders including dysfunction of gastrointestinal motility and function such as inflammatory bowel disease, irritable bowel syndrome, diarrhea, constipation, gastric acid secretion and ulcers; pheochromocytoma; cardiovascular dysfunction including hypertension and cardiac arrhythmias, comedication in surgical procedures, and the like. The compounds of the present invention are especially useful for the treatment of Alzheimer's disease as well as other types of dementia (including dementia associated with AIDS), Parkinson's disease, cognitive dysfunction (including disorders of attention, focus and concentration) , attention deficit syndrome, affective disorders, and for the control of pain. Thus modulation of the activity of acetylcholine receptors present on or within the cells of a patient suffering from any of the above-described indications will impart a therapeutic effect. As employed herein, the phrase "an effective amount", when used in reference to compounds of the invention, refers to doses of compound sufficient to provide circulating concentrations high enough to impart a beneficial effect on the recipient thereof. Such levels typically fall in the range of about 0.001 up to 100 mg/kg/day; with levels in the range of about 0.05 up to 10 mg/kg/day being preferred. The invention will now be described in greater detail by reference to the following non-limiting examples. Example 1 Synthesis of invention pyridine compounds via Synthetic Scheme I Formation of imine. Method A: Into a two-necked, round-bottomed flask fitted with a condenser and flushed with nitrogen was placed compound II (wherein are each H, and R is H or methyl), 2.5 ml/mmole of dry dimethyl ether (DME) and 1 to 1.5 eq of the liquid amine, N a R°H 2 (wherein R a is selected from cyclopropyl, isopropyl or phenylpropyl) . The reaction mixture was cooled to 0°C and 0.2 to 0.5 eq of a 1M solution of TiCl 4 in methylene chloride was added. After stirring for 30 minutes at 0°C, the mixture was allowed to warm to room temperature and stirred for 2 to 6 hours. Then phosphate buffer (4 ml/mmole; pH=6.8) was added and the solution extracted three times with ether. The organic phases were combined, washed with brine, dried (MgS0 4 ) and concentrated under vacuum (15mm Hg) to give a compound pure enough for the reduction step used to prepare the desired product. Formation of imine . Method B: Into a two-necked, round-bottomed flask fitted with a dry ice condenser and flushed with nitrogen was P ~t A placed compound II (wherein R , R , R and R are each H, and R is H or methyl) and 2.5 ml/mmole of dry dimethyl ether (DME) and cooled to 0°C. An excess of the gaseous amine, N a R°H 2 (wherein R a is methyl) was condensed into the reaction mixture and 0.5 eq of 1M TiCl 4 in solution in methylene chloride was added. The mixture was warmed up to room temperature and stirred for 2 to 6 hours. Work up was accomplished following the same procedure described in Method A. α-Methyl-N-methyl-3-picolylimine (Method B) : 3-acetylpyridine (4.0g; 33.01 mmole), methylamine (in excess) and TiCl 4 (0.3 eq) were stirred for 12 h at room temperature. 4.1g of crude material were obtained, 90% conversion. 1 H NMR (300 MHz, CDC1 3 ) 5 9.18 (d, J=2Hz, 1H) , 8.96 (dd, J=4Hz and 2Hz, 1H) , 8.08 (dt, J=2Hz and 6Hz, 1H) , 7.30 (dd, J=6Hz and 4Hz 1H) , 3.45 (s, 3H) , 2.27 (s, 3H) . α-Methyl-N-isopropyl-3-picolylimine (Method A) 3-Acetylpyridine (l.Og; 8.26 mmole), isopropylamine (0.54g; 9.90 mmole) and TiCl 4 (0.5 eq) were stirred for 3 h at room temperature. l.lg of crude material were obtained, 90% conversion. H NMR (300 MHz, CDC1 3 ) δ 8.95 (d, J=2Hz, IH) , 8.60 (dd, J=2Hz and 5Hz, IH) , 8.09 (dt, J=2Hz and 8Hz, IH) , 7.30 (dd, J=5Hz and 8Hz, IH) , 3.85 (sept, J=6Hz, IH) , 2.26 (s, 3H) , 1.22 (d, J=6Hz, 6H) . α-Methyl-N-cyclopropyl-3-picolylimine (Method A) 3-Acetylpyridine (4.0g, 33.04 mmole), cyclopropylamine (2.82g, 49.5 mmole, 1.5 eq) and TiCl 4 (0.5 eq) were stirred for 3 h at room temperature. 4.85g of crude material were obtained, 98% conversion. H NMR (300 MHz, CDC1 3 ) δ 9.18 (d, J=2Hz, IH) , 8.80 (dd, J=2Hz and 5Hz, IH) , 8.24 (dt, J=2Hz and 7Hz, IH) , 7.43 (dd, J=5Hz and 7Hz, IH) , 2.87 (s, 3H) , 0.95 (m, 4H) . N-Cyclopropyl-3-picolylimine (Method A) 3-carboxyaldehyde pyridine (6g, 56.01 mmole), cyclopropylamine (4.8g, 84.01 mmole, 1.5 eq) and TiCl 4 (0.1 eq) were stirred for l h at room temperature. 7.4g of crude material were obtained, 100% conversion, 90% yield. 1 H NMR (300 MHz, CDC1 3 ) <5 8.80 (d, J=2Hz, IH) , 8.60 (dd, J=2Hz and 5Hz, IH) , 8.06 (dt, J=2Hz and 7Hz, IH) , 7.31 (dd, J=5Hz and 7Hz, IH) , 3.07 (m, IH) , 1.19 (m, 4H) . N-Phenylpropyl-3-picolylimine (Method A) 3-Carboxyaldehyde pyridine (l.Og, 9.33 mmole), 3-phenyl-l-propylamine (1.26g, 9.33 mmole) and TiCl 4 (0.1 eq) were stirred for 3 h at room temperature. 2.2 g of crude material were obtained, 95% conversion. H NMR (300 MHz, CDC1 3 ) δ 8.86 (d, J = 2Hz, IH) , 8.65 (dd, J = 2Hz and 5Hz , IH) , 8 . 31 ( s , IH) , 8 . 11 (dt , J = 2Hz and 7Hz , IH) , 7 . 38 - 7 . 16 (m , 6H) , 3 . 69 (m , 2H) , 2 . 72 (m , 2H) , 2 . 04 (m, 2H) . Reduction of imine to amine. Method C: Into a one-necked, round-bottomed flask was introduced imine, sodium cyanoborohydride (2 eq) , methanol (lml/mmole) and a trace of bromcresol green indicator. To this blue solution was added dropwise 2M HC1 in dioxane such that the yellow end" point was barely maintained. The resulting yellow solution was stirred 20 minutes at room temperature followed by addition of 2M HCl in dioxane (half of the quantity used previously) . The resulting solution was stirred for one more hour at room temperature and concentrated under reduced pressure. To the resulting crude material was added water (2ml/mmole) . The solution was basified with aqueous NaOH (IN) and extracted three times with methylene chloride. The organic layers were combined, dried (MgS0 4 ) and concentrated under reduced pressure. The crude material was purified via chromatography on silica using CHC1 3 or CHCl 3 /MeOH (99:1) as eluant. α-Methyl-N-methyl-3-picolylamine (Method C) : α-Methyl-N-methyl-3-picolylimine (0.50g, 3.75 mmole) and NaBH 3 CN (2 eq) yielded 264mg of the pure compound (70%). 1 H NMR (300 MHz, CDC1 3 ) δ 8.54 (d, J=2Hz, IH) , 8.50 (dd, J=2Hz and 5Hz, IH) , 7.66 (dt, J=2Hz and 7Hz, IH) , 7.26 (dd, J=5Hz and 7Hz, IH) , 3.70 (q, J=7Hz, IH) , 2.31 (s, 3H) , 1.37 (d, J=7Hz, 3H) . 90 mg of α-methyl-N-methyl-3-picolylamine was converted to the dihydrobromide salt. 160mg of the dihydrobromide product were obtained, 81% yield. H NMR (300 MHZ, CD 3 0D) δ 9.11 (s, IH) , 8.9 (d, J=4Hz, IH) , 8.84 (d, J=6Hz, IH) , 8.14 (dd, J=8Hz and 4Hz, IH) , 4.78 (q, J=7Hz, 3H) , 2.60 (s, 3H) , 1.70 (d, J=7Hz, 3H) ; 13 C NMR (75.5 MHz, CD 3 0D) δ 150.2, 149.3, 145.9, 140.1, 131.8, 59.3, 34.3, 20.4; mp: 210-211°C; C, H, N Analysis: C 8 H 12 N 2 , 2HBr. α-Methyl-N-isopropyl-3-picolylamine (Method C) : o-Methyl-N-isopropyl-3-picolylimine (0.50g, 3.08 mmole) and NaBH 3 CN (1.5 eq) yielded 0.30g of pure compound (60%). 1 H NMR (300 MHz, CDC1 3 ) <S 8.54 (d, J=2Hz, IH) , 8.49 (dd, J=2Hz and 5Hz, IH) , 7.65 (dt, J=2Hz and 8Hz, IH) , 7.25 (dd, J=5Hz and 7Hz, IH) , 3.94 (d, J=7Hz, IH) , 2.60 (sept, J=6Hz, IH) , 1.35 (d, J=7Hz, 3H) , 1.07 (d, J=6Hz, 3H) , 0.98 (d, J=6Hz, 3H) . 100 mg of o-methyl-N-isopropyl-3-picolylamine was converted to the dihydrobromide salt (134 mg, 68%) . 1 H NMR (300 MHz, CD 3 0D) 5 9.19 (s, IH) , 8.90 (m, 2H) 8.15 (t, J=7Hz, IH) , 4.92 (m, IH) , 3.33 (m, IH) , 1.71 (d, J=7Hz, 3H) , 1.31 (d, J=7HZ, 6H) ; 13 C NMR (75.5 MHz, CD 3 0D) <S 147.6, 144.0, 143.5, 138.8, 53.3, 50.4, 19.5, 19.4, 19.0; mp = 126-127°C. α-Methyl-N-cyclopropyl-3-picolylamine (Method C) : α-Methyl-N-cyclopropyl-3-picolylimine (2.43g, 15 mmole) and NaBH 3 CN (2 eq) yielded 1.82g of the pure compound (74.8%) . 1 H NMR (300 MHz, CDC1 3 ) δ 8.56 (d, J=2Hz, IH) , 8.50 (dd, J=5Hz and 2Hz, IH) , 7.65 (dt, J=7Hz and 2Hz, IH) , 7.26 (dd, J=2Hz and 5Hz, IH) , 1.39 (d, J=6Hz, 3H) , 0.40 (m, 4H) . 1.12g of α-methyl-N-cyclopropyl-3-picolylamine was converted to the fumaric acid salt (0.68 g, 30%). H NMR (300 MHz, CD 3 0D) δ 8.52 (d, J=2Hz, IH) , 8.47 (dd, J=2Hz and 5Hz, IH) , 7.88 (dt, J=2Hz and 7Hz, IH) , 7.42 (dd, J=5Hz and 7Hz, IH) , 6.60 (s, 3.6H) , 4.40 (q, J=6Hz, IH) , 2.38 (m, IH) , 1.57 (d, J=6Hz, 3H) , 0.67 (m, 4H) ; 13 C NMR (75.5 MHz, CD 3 0D) δ 169.9, 150.7, 135.8, 125.8, 57.9, 29.7, 18.9, 4.32; mp = 144 - 145°C; C, H, N Analysis: C 10 H 14 N 2 1.8(C 4 H 4 0 4 ) . N-Cyclopropyl-3-picolylamine (Method C) : N-Cyclopropyl-3-picolylimine (2g, 13.6 mmole) and NaBH 3 CN (2 eq) yielded 1.57g of the pure compound (77%). 1 H NMR (300 MHz, CDC1 3 ) <S 8.56 (d, J=2Hz, IH) , 8.50 (dd, J=2Hz and 5Hz, IH) , 7.66 (dt, J=2Hz and 7Hz, IH) , 7.25 (dd, J=5Hz and 7Hz, IH) , 3.82 (s, 2H) , 2.11 (m, IH) , 1.91 (brs, IH) 0.45 (m, 4H) . 259 mg of N-cyclopropyl-3-picolylamine was converted to the fumaric acid salt (273 mg, 43%) . H NMR (300 MHz, CDC1 3 ) δ 8.54 (d, J=2Hz, IH) , 8.47 (dd, J=2Hz and 5Hz, IH) , 7.86 (dt, J=2Hz and 5Hz , IH) , 7.38 (dd, J=5Hz and 7HZ, IH) , 6.60 (s, 3.4H) , 4.20 (s, 2H) , 2.61 (m, IH) , 0.73 (m, 4H) ; mp = 126 - 127°C; C, H, N Analysis: C 9 H 12 N 2 1.7(C 4 H 4 0 4 ). N-Phenylpropyl-3-picolylamine (Method C) : N-Phenylpropyl-3-picolylimine (2.10g, 9.37 mmole) and NaBH 3 CN (2 eq) yielded 1.20g of the pure compound (57%). 1 H NMR (300 MHZ, CDC1 3 ) δ 8.53 (d, J=2Hz, IH) , 8.48 (dd, J=2Hz and 6Hz, IH) , 7.66 (dt, J=2Hz and 7Hz, IH) , 7.31-7.16 (m, 6H) , 3.78 (s, 2H) , 2.67 (m, 4H) , 1.84 (m, 2H) . 0.30 g of N-phenylpropyl-3-picolylamine was converted to the fumaric acid salt (0.41 g, 75%) . H NMR (300 MHz, CD 3 0D) δ 8.54 (d, J=2Hz, IH) , 8.50 (dd, J=6Hz and 2Hz, IH) , 7.85 (dt, J=2Hz and 7Hz , IH) , 7.41 (dd, J=6Hz and 7Hz, IH) , 7.20 - 7.05 (m, 5H) , 6.6 (s, 3.2H) , 4.15 (s, 2H) , 2.96 (m, 2H) , 2.61 (m, 2H) , 1.91 (m, 2H) ; mp = 141-142°C; C, H, N Analysis: C 15 H 18 N 2 1.6(C 4 H 4 0 4 ) . Alkylation of amine. Method D: Into a one-necked, round-bottomed flask was introduced the amine and acetonitrile (10 ml/mmole) . To the resulting solution was added formaldehyde (37%) and sodium cyanoborohydride (1.5 to 2 eq) . After stirring at 0°C for 30 minutes, acetic acid was introduced and the crude mixture was stirred at room temperature overnight. The resulting solution was concentrated under reduced pressure, the residue was taken into H 2 0 and basified with NaOH. The aqueous solution was extracted with CH 2 C1 2 . The organic layers were combined, washed with brine, dried (MgS0 4 ) and concentrated under reduced pressure, yielding an oil. The crude material was purified via chromatography on silica using CHC1 3 in general as eluant. α-Methyl-N,N-dimethyl-3-picolylamine (Method D) : α-Methyl-N-methyl-3-picolylamine (0.58g, 4.29 mmole), formaldehyde (37%, 1.63 ml), sodium borohydride (0.41g, 6.47 mmole) and acetic acid (200μl) were used. 0.37 g of pure material was obtained (58%) . 1 H NMR (CDC1 3 , 300 MHz) δ 8.55 (s, IH) , 8.50 (d, J=6Hz, IH) , 8.12 (d, J=7Hz, IH) , 7.64 (dd, J=7Hz and 6Hz, IH) , 3.46 (d, J=6Hz, IH) , 2.21 (s, 6H) , 1.38 (d, J=6Hz, 3H) . 100 mg of α-methyl-N,N-dimethyl-3-picolylamine was converted to the bromine salt (167 mg, 80%) . H NMR (300 MHz, CD 3 OD) δ 8.89 (s, IH) , 8.78 (d, J=6Hz, IH) , 8.58 (d, J=8Hz, IH) , 7.95 (dd, J=6Hz and 8Hz, IH) , 4.84 (q, J=7Hz, IH) 2.25 (s, 6H) , 1.78 (d, J=7Hz, 3H) ; mp = 178-179°C. N-Methyl-N-cyclopropyl-3-picolylamine: Into a 100 ml two-necked flask fitted with a dropping funnel and flushed with nitrogen was introduced N-cyclopropyl-3-picolylamine (500mg, 3.37 mmole) and dimethylformamide (10 mL) . The reaction mixture was placed in an ice bath and oil free sodium hydride (65.2mg, 2.73 mmole) was added. After 5 minutes the ice bath was removed and the mixture was stirred at room temperature for 10 minutes. Then iodomethane (42mg, 2.96 mmole) was added slowly at 0°C. After an hour, TLC analysis indicated that the reaction was not complete, thus more sodium hydride (13.3mg, 0.54 mmole) and iodomethane (0.1 mL) were added. After 12 h at room temperature, the mixture was hydrolyzed with cold water (20 mL) and extracted with ethyl acetate (3 x 15 mL) . The combined organic phases were washed with brine (25 ml) , dried (MgS0 4 ) , and concentrated under vaccuum (15 mm Hg) to give brown oil (121 mg, 0.745 mmole, 22%) . N-Methyl-N-cyclopropyl-3-picolylamine was converted to the fumaric acid salt (192mg, 0.55 mmole, 74%). 1 H NMR (300 MHz, CD 3 0D) δ 8.44 (d, J=2Hz, IH) , 8.37 (dd, J=2Hz and 5Hz, IH) , 7.76 (d, J=7HZ, IH) , 7.30 (dd, J=5Hz and 7Hz, IH) , 6.53 (s, 3.2H), 4.02 (S, 2H) , 2.48 (s, 3H) , 2.20 (m, IH) , 0.51 (m, 4H) ; 13 C NMR (75.5 MHz, CD 3 OD) δ 169.3, 151.9, 150.3, 140.9, 135.6, 131.1, 125 . A , 59.4, 42.3, 39.8, 6.31; mp = 126 - 127°C; C, H, N Analysis: C 10 H 14 N 2 1.6(C 4 H 4 0 4 ). N-Methyl-N-phenylpropyl-3-picolylamine (Method D) : N-Phenylpropyl-3-picolylamine (0.60mg, 2.65 mmole), formaldehyde (37%, lmL) , sodium borohydride (0.25g, 3.98 mmole) and acetic acid (122μl) yielded 220mg of pure material (35%) . N-Methyl-N-phenylpropyl-3-picolylamine (180mg, 0.75 mmole) was converted to the fumaric acid salt (240 mg, 0.67 mmole, 89%) . 1 H NMR (300 MHz, CD 3 0D) 5 8.32 (s, IH) , 8.52 (d, J=6Hz, IH) , 8.17 (d, J=7Hz, IH) , 7.69 (dd, J=6Hz and 7Hz, IH) , 7.14-6.99 (m, 5H) , 6.58 (s, 2H) , 3.95 (m, 2H) , 2.66 (m, 2H) , 2.53 (m, 2H) , 2.39 (s, 3H) , 1.89 (m, 2H) ; 13 C NMR (75.5 MHZ, CD 3 0D) <5 169.7, 149.8, 148.5, 142.9, 135.8, 129.5, 128.1, 127.2, 59.1, 57.1, 41.07, 33.8, 28.2; mp = 129 - 130°C. Example 2 5-Bromo-3-.N-methoxy-N-methyl.pyridinecarboxamide To a slurry of 5-bromo-3-pyridinecarboxylic acid (22.2 g, 110 mmol) in 1,2-dichloroethane (50 mL) , thionyl chloride (24 mL, 330 mmol) was slowly added over a period of 30 min with intermittent cooling in an ice bath to maintain a temperature below 20°C. The reaction was allowed to warm to room temperature, and heated to reflux for 18 h. The reaction mixture was cooled to 10°C, and additional thionyl chloride (4 mL, 50 mmol) was added dropwise. The reaction was warmed to reflux for 6 h, then allowed to cool to room temperature. Residual thionyl chloride and solvent were removed by rotary evaporation followed by high vaccum to provide 5-bromo-3-pyridine- carbacyl chloride hydrochloride as a colorless solid (28.4 g, 100%) . To a suspension of this material in 1,2-dichloroethane (300 mL) at -10°C was added N,O-dimethylhydroxylamine hydrochloride (10.73 g, 110 mmol) , followed by the dropwise addition of triethylamine (31 mL, 220 mmol) . The mixture was stirred at 25°C for 48 h before water (200 mL) was added. The organic phase was separated and the aqueous phase was extracted with chloroform (2 x 50 mL) . The combined organic extracts were washed with saturated sodium carbonate solution (50 mL) , brine (50 mL) then dried (MgS0 4 ) and concentrated in vacuo. The crude material was chromatographed on silica gel with ethyl acetate-hexane (1:2) as eluant to afford the title compound as an oil, 25.7 g, 95%. LRMS (El) m/e 246 (C 8 H 9 BrN 2 0 2 , M), 244 (C 8 H 9 BrN 2 0 2 , M); H NMR (CDC1 3 , 300 MHz) : δ 8.87 (d, J=1.2Hz, IH) , 8.76 (d, J=2.1Hz , IH) , 8.19 (m, IH) , 3.58 (s, 3H) , 3.39 (s, 3H) . Example 3 5-Bromo-3-pyridinecarboxaldehvde 5-Bromo-3- (N-methoxy-N-methyl) pyridine carboxamide (25 g, 102 mmol) was dissolved in toluene (250 mL) under inert atmosphere. The resulting mixture was cooled to -10°C with stirring. Diisobutylaluminum hydride (88.4 mL of a 1.5 M solution in toluene, 132.6 mmol) was added, keeping the reaction temperature at -10°C, and after the addition the mixture was stirred at 0°C for 1 h. The solution was again cooled to -10°C and a further 0.2 equivalent of diisobutylaluminum hydride (17 mL of a 1.5 M solution in toluene, 25.5 mmol) was added; stirring was then continued at 0°C for 30 minutes. The reaction mixture was poured into 1 M HCl (500 mL) with stirring and this was cooled to 0°C and the pH adjusted to 10 with NaOH (solid) . The solution was extracted with isopropyl acetate (2 x 500 mL) , the combined organic layers washed with water (2 x 250 mL) , brine (300 mL) , dried (Na 2 S0 4 ) and concentrated in vacuo to afford a yellow solid (14.5 g) . The combined aqueous fractions were filtered through celite, extracted with isopropyl acetate (2 x 200 mL) , the combined organic layers washed with water (100 mL) , brine (100 mL) , dried (Na 2 S0 4 ) and concentrated in vacuo to afford a second crop of yellow solid. The crude materials were combined and chromatographed on silica gel with ethyl acetate-hexane (3:7) as eluant to afford the title compound as a solid, 8.75 g, 46%. M.p. 97-98°C; 'H NMR (DMSO-d 6 , 300 MHz): δ 10.08 (s, IH) , 9.06 (bs, IH) , 9.01 (d, J=2Hz, IH) , 8.48 (t, J=2Hz, IH) . Example 4 5-Bromo-3-(N-pyrrolidinomethyl.pyridine 5-Bromo-3-pyridinecarboxaldehyde (8.75 g, 47 mmol) and pyrrolidine (7.85 mL, 94 mmol) were dissolved in acetonitrile (250 mL) with stirring. The reaction mixture was chilled (0°C) , sodium cyanoborohydride (5.92 g, 94 mmol) was added and the mixture stirred at 0°C for 30 minutes. Glacial acetic acid (5 mL) was added dropwise and the mixture stirred at 25°C for 3 h. Water (200 mL) was added and the mixture extracted with ethyl acetate (2 x 250 mL) . The combined organic layers were washed with water (2 x 100 mL) , brine (150 mL) , dried (Na 2 S0 4 ) and concentrated in vacuo . The crude material was chromatographed on silica gel with methanol-methylene chloride (1:19) as eluant to afford the title compound as an oil, 9 g, 80%. LRMS (El) m/e 242 ( 81 Br, M + ) , 241 ( 81 Br, M * -H) , 240 (V, M + ) , 239 (^Br, M * -H) ; 1 H NMR (CDC1 3 , 300 MHz) : δ 8.56 (d, J=2Hz, IH) , 8.45 (bs, IH) , 7.87 (s, IH) , 3.61 (s, 2H) , 2.52 (bs, 4H) , 1.81 (m, 4H) . Example 5 4-Bromophenv1-tert-butvIdimethv1si1v1 ether 4-Bromophenol (5.76 g, 30 mmol), imidazole (4.08 g, 60 mmol) and tert-butyldimethylsilyl chloride (5.02 g, 33 mmol) were stirred in anhydrous DMF (100 mL) at 25°C for 18 h. The reaction mixture was then poured into water (100 mL) and extracted with ethyl acetate (2 x 75 mL) . The combined extracts were washed with water (2 x 75 mL) , brine (75 mL) and dried (MgS0 4 ) before concentration in vacuo . The crude product was chromatographed on silica gel with ethyl acetate:hexane (1:4) as eluant to afford the title compound as an oil, 7.9 g, 92%. 1 H NMR (CDC1 3 , 300 MHz): δ 7.33 (app. dt, J=9Hz, 3Hz and 1Hz, 2H) , 6.73 (app. dt, J=9HZ, 3HZ and 1Hz, 2H) 0.98 (s, 9H) , 0.21 (s, 6H) . Example 6 4-Bromo-3-chlorophenyl-tert-butyldimethylsilyl ether Repeating the procedure of Example 5, but using the appropriate starting materials in place of 4-bromophenol, the following compound was obtained: 4-Bromo-3-chlorophenyl-tert-butyldimethylsilyl ether H NMR (CDC1 3 , 300 MHz): δ 7.47 (d, J=2Hz, IH) , 7.24 (dd, J=9Hz and 2Hz, IH) , 6.75 (d, J=9Hz, IH) , 1.02 (s, 9H),0.22 (s, 6H) . Example 7 5-.4-Hvdroxyphenyl. -3-.N-pyrrolidinomethyl) yridine fumarate To a stirred solution of 4-bromophenyl- tert-butyldimethylsilyl ether (2.14 g, 7.5 mmol) in anhydrous diethyl ether (10 mL) at -78°C under inert atmosphere was slowly added t-butyllithium (8.8 mL of a 1.7 M solution in pentane, 15 mmol) . This was stirred at -78°C for 30 minutes and zinc chloride (7.5 mL of a 1 M solution in diethyl ether, 7.5 mmol) was added. The mixture was allowed to warm to 25°C over 30 minutes before being cannulated into a stirred solution of 5-bromo- 3-(N-pyrrolidinomethyl)pyridine (900 mg, 3.7 mmol) and bis(triphenylphosphine)palladium(II) chloride (155 mg, 0.22 mmol) in anhydrous THF (10 mL) at 25°C under inert atmosphere. The reaction mixture was stirred for 18 h before being poured into a saturated solution of potassium sodium tartrate (20 mL) . The solids were removed by filtration, the organic phase separated and the aqueous phase washed with ethyl acetate (2 x 100 mL) . The combined organic layers were washed with saturated NaHC0 3 solution (50 mL) , water (2 x 50 mL) , brine (50 mL) , dried (MgS0 4 ) and the solvents removed in vacuo . The resulting oil was dissolved in methanol (50 mL) and filtered through paper to remove residual solid catalyst. The filtrate was concentrated under reduced pressure before purification using silica gel column chromatography with ethyl acetate-hexane (1:1) as eluant to afford 5-(4-tert-butyldimethylsilyloxy- phenyl) -3-(N-pyrrolidinomethyl)pyridine, 1.15 g, 42% as an oil. LRMS (El) m/e 368 (M * ) , 367 (M + -H) ; 1 H NMR (CDC1 3 , 300 MHz): δ 8.70 (d, J=1.5Hz, IH) , 8.46 (bs, IH) , 7.91 (s, IH) , 7.48 (d, J=8HZ, 2H) , 6.92 (d, J=8Hz, 2H) , 3.72 (s, 2H) , 2.60 (s, 4H) , 1.83 (s, 4H) , 1.00 (s, 9H) , 0.22 (s, 6H) . This material (1.15 g, 3.13 mmol) was dissolved in methanol (20 mL) and cesium fluoride (950 mg, 6.25 mmol) was added. The stirred mixture was heated at reflux for 18 h under inert atmosphere. After cooling the solvent was removed in vacuo and the resulting oil was dissolved in ethyl acetate (100 mL) . This was washed with water (2 x 50 mL) , brine (50 mL) , dried (MgS0 4 ) and concentrated. The crude material was chromatographed on "flash" silica gel with 5% methanol:ethyl acetate as eluant to afford 5-(4-hydroxyphenyl) -3-(N-pyrrolidinomethyl)pyridine 640mg, 80%. LRMS (El) m/e 254 (M + ) , 253 (M + -H) ; 'H NMR (CDCl 3 , 300 MHz): δ 8.64 (d, J=2Hz, IH) , 8.40 (d, J=2Hz, IH) , 7.76 (t, J=2HZ, IH) , 7.17 (d, J=8Hz, 2H) , 6.63 (d, J=8Hz, 2H) , 3.73 (S, 2H) , 2.67 (s, 4H) , 1.87 (s, 4H) . The latter product was converted to the title compound by the addition of one equivalent of fumaric acid to a methanol (15 mL) solution of the free amine at 25°C. After 30 minutes the solvent was removed in vacuo and the residue pumped under high vacuum. Trituration with diethyl ether followed by recrysta] lization from ethyl acetate afforded 5- (4-hydroxyphenyl) -3-(N-pyrrolidinomethyl) - pyridine fumarate, (55%). M.p. 177-179°C (EtOAc) ; 1 H NMR (DMSO-d 6 , 300 MHZ): δ 8.79 (s, IH) , 8.51 (s, IH) , 8.07 (s, IH) , 7.57 (d, J=8Hz, 2H) , 6.89 (d, J=8Hz , 2H) , 6.58 (S, 2H) , 4.05 (s, 2H) , 2.89 (s, 4H) , 1.84 (s, 4H) . Example 8 5-Substituted-3- .N-pyrrolidinomethyl. pyridines Repeating the procedure of Example 7, but using the appropriate starting materials in place of 4-bromophenyl-tert-butyldimethylsilyl ether, the following 5-substituted-3-(N-pyrrolidinomethyl)pyridine compounds were obtained: (a) 5-(4-tert-Butyldimethylsilyloxy-3-chlorophenyl)- 3-(N-pyrrolidinomethyl)pyridine: 1 H NMR (CDC1 3 , 300 MHz): δ 8.68 (d, J=2Hz, IH) , 8.50 (d, J=2Hz, IH) , 7.82 (bs, IH) , 7.61 (d, J=2Hz, IH) , 7.37 (dd, J=9Hz and 2Hz, IH) , 6.97 (d, J=9HZ, IH) , 3.68 (s, 2H) , 2.54 (s, 4H) , 1.82 (s, 4H) , 1.05 (s, 9H) , 0.26 (s, 6H) . (b) 5-(4-Hydroxy-3-chlorophenyl) -3-(N-pyrrolidino¬ methyl)pyridine: LRMS (El) m/e 290 ( 37 Cl, M + ) , 289 ( 37 C1, M + -H) , 288 ( 35 C1, M + ) , 287 ( 35 C1, M * -H) ; 1 H NMR (CDC1 3 , 300 MHz): δ 8.62 (d, J=3Hz, IH) , 8.44 (d, J=3Hz, IH) , 7.73 (t, J=3Hz, IH) , 7.40 (d, J=2Hz, IH) , 7.09 (dd, J=8Hz and 2Hz, IH) , 6.67 (d, J=8Hz, IH) , 3.74 (S, 2H) , 2.68 (s, 4H) , 1.88 (s, 4H) . (c) 5-(4-Hydroxy-3-chlorophenyl) -3-(N-pyrrolidino¬ methyl)pyridine fumarate: M.p. 192-193°C (EtOAc) ; 1 H NMR (DMSO-d 6 , 300 MHz) : δ 8.58 (s, IH) , 8.30 (s, IH) , 7.86 (s, IH) , 7.49 (s, IH) , 7.31 (d, J=8Hz, IH) , 6.85 (d, J=8Hz, IH) , 6.33 (s, 2H) , 3.82 (s, 2H) , 2.65 (s, 4H) , 1.59 (s, 4H) . Example 9 5-Ethynyl-3- .N-pyrrolidinomethyl.pyridine fumarate 5-Bromo-3-(N-pyrrolidinomethyl)pyridine (1.2 g, 5 mmol), tetrakis(triphenylphosphine)palladium(0) (289 mg, 0.25 mmol), copper(I)iodide (95 mg, 0.5 mmol) and triethylamine (5 mL) were stirred in 1,2-dimethoxyethane (5 mL) at 25°C under inert atmosphere. After 10 minutes, trimethylsilylacetylene (1.4 mL, 10 mmol) was added to the mixture and this was stirred for 18 h. Water (30 mL) and ethyl acetate (50 mL) were added and the organic phase separated. The aqueous layer was extracted with ethyl acetate (2 x 20 mL) and the combined organic extracts were washed with brine (20 mL) , dried (MgS0 4 ) and filtered before the solvents were removed in vacuo . The resulting oil was chromatographed on silica gel with ethyl acetate-hexane (1:9, 1:4) as eluant to afford 5-trimethylsilylethynyl- 3-(N-pyrrolidinomethyl)pyridine, 371 mg, 29%. LRMS (El) m/e 260 (M + +2), 259 (M + +H) , 258 (M + ) , 257 (M + -H) ; 1 H NMR (CDC1 3 , 300 MHz): <S 8.58 (d, J=2Hz, IH) , 8.47 (d, J=2Hz, IH) , 7.77 (app. t, J=2Hz, IH) , 3.59 (s, 2H) , 2.50 (m, 4H) , 1.80 (m, 4H) , 0.26 (s, 9H) . 5-TrimethyIsilylethyny1-3-(N-pyrrolidinomethyl) pyridine (371 mg, 1.4 mmol) and cesium carbonate (100 mg) were dissolved in methanol (10 mL) and heated under reflux for 18 h. After cooling, the solvents were removed in vacuo and water (10 mL) was added. The aqueous solution was extracted with ethyl acetate (3 x 10 mL) , the combined organic extracts washed with brine (10 mL) , dried (MgS0 4 ) and concentrated in vacuo . The crude product was chromatographed on silica gel with ethyl acetate-hexane (1:9, 1:4, 1:1) as eluant to afford 5-ethynyl- 3-(N-pyrrolidinomethyl)pyridine as an oil, 158 mg, 61%. This was converted to the title compound by the addition of one equivalent of fumaric acid to a methanol (10 mL) solution of the free amine at 25°C. After 30 minutes the solvent was removed in vacuo and the residue pumped under high vacuum. Trituration with diethyl ether followed by recrystallization from ethyl acetate afforded 5-ethγnyl-3-.N-pyrrolidinomethyl.pyridine fumarate. M.p. 148-150°C (decomp., EtOH-EtOAc) ; 1 H NMR (DMSO-d 6 , 300 MHz) : δ 8.64 (s, IH) , 8.62 (s, IH) , 7.97 (s, IH) , 6.60 (s, 4H) , 4.50 (s, IH) , 3.99 (s, 2H) , 2.82 (s, 4H) , 1.81 (s, 4H) . Example 10 5-Phenyl-3- .N-roethoxy-A.-methyl.pyridinecarboxamide 5-Bromo-3- (N-methoxy-N-methy1)pyridinecarboxamide (3.0 g, 12.25 mmol), tributylphenyltin (5.13 g, 14 mmol) and triphenylarsine (428 mg, 1.4 mmol) were dissolved in anhydrous DMF (75 mL) with stirring. Bis(dibenzylidene- acetone)palladium (402 mg, 5 mol%) was added, and the mixture was stirred at 65°C for 24 h. Ethyl acetate (100 mL) , water (100 mL) and 10% ammonium hydroxide (75 mL) were added to the cooled mixture, which was agitated before filtration through celite. The organic layer was separated and the aqueous phase extracted with ethyl acetate (100 mL) . The combined organic extracts were washed with water (2 x 50 mL) , brine (50 mL) , dried (MgS0 4 ) and concentrated in vacuo . The residue was chromatographed on silica gel with ethyl acetate-hexane (2:3) as eluant to afford the title compound as an oil (1.7 g, 57%). LRMS (El) m/e 243 (M + +H) , 242 (M + ) ; 1 H NMR (CDC1 3 , 300 MHz): δ 8.93 (s, 2H) , 8.23 (m, IH) , 7.63 (d, J=8Hz, 2H) , 7.40-7.55 (m, 3H) , 3.60 (s, 3H) , 3.43 (s, 3H) . Example 11 5-Phenyl-3-pyridinecarboxaldehvde 5-Phenyl-3-(N-methoxy-N-methyl)pyridine- carboxamide (1.32 g, 5.45 mmol) was dissolved in THF (30 mL) under inert atmosphere, then cooled to -70°C with stirring. Diisobutylaluminum hydride (11 mL of a 1M solution in cyclohexane, 11 mmol) was added. After addition was complete, the mixture was stirred at -70°C for 2h. Saturated ammonium chloride solution (1 mL) was added to the reaction mixture, followed by water (15 mL) and chloroform (50 mL) . The mixture was filtered through celite, the organic phase separated and the aqueous phase again extracted with chloroform (80 mL) . The combined organic extracts were washed with water (2 x 50 mL) , brine (50 mL) , dried (MgS0 4 ) and concentrated in vacuo . The crude material was chromatographed on silica gel with ethyl acetate-hexane (2:3) as eluant to afford the title compound as an oil, 790 mg, 80%. LRMS (El) m/e 185 (M + +2) , 184 (M + +H) , 183 (M + ) , 182 (M + -H) ; 1 H NMR (CDC1 3 , 300 MHz) : δ 10.20 (s, IH) , 9.08 (d, J=2Hz, IH) , 9.05 (d, J=2Hz, IH) , 8.35 (t, J=2Hz, IH) , 7.63 (m, 2H) , 7.45-7.55 (m, 3H) . Example 12 5-Phenyl-3-.N-pyrrolidinomethyl) yridine 5-Phenyl-3-pyridinecarboxaldehyde (400 mg, 2.18 mmol) and pyrrolidine (300 mg, 4.39 mmol) were dissolved in acetonitrile (20 mL) with stirring. The reaction mixture was chilled (0°C) , sodium cyanoborohydride (30 mg, 4.4 mmol) was added and the mixture stirred at 0°C for 30 minutes. Glacial acetic acid (0.25 mL) was added dropwise and the mixture stirred at 25°C for 18 h. 1M HC1 (10 mL) and methanol (10 mL) were added and the mixture concentrated in vacuo . Water (20 mL) was added and the solution basified with solid sodium hydroxide. This was extracted with methylene chloride (3 x 30 mL) and the combined organic extracts were washed with water (20 mL) , brine (20 mL) , dried (MgS0 4 ) and concentrated in vacuo . The crude material was chromatographed on silica gel with ethyl acetate-hexane (2:3) as eluant to afford the title compound as an oil, 360 mg, 70%. This was converted to the fumarate derivative of the title compound by the addition of one equivalent of fumaric acid to a methanol (10 mL) solution of the free amine at 25°C. After 30 minutes, the solvent was removed in vacuo and the residue pumped under high vacuum. Trituration with diethyl ether, followed by recrystallization from ethyl acetate afforded 5-phenyl-3- ■N-pyrrolidinomethyl)pyridine fumarate; M.p. 126-127°C (EtOAc) ; 1 H NMR (DMSO-d 6 , 300 MHz): δ 8.82 (s, IH) , 8.62 (s, IH) , 8.20 (s, IH) , 7.72 (bs, 2H) , 7.50 (bs, 3H) , 6.58 (S, 2H) , 4.15 (s, 2H) , 2.97 (s, 4H) , 1.85 (s, 4H) . Example 13 5-Phenyl-3-.iV-azetidinomethyl)pyridine fumarate Repeating the procedure of Example 12, but using the appropriate starting materials in place of pyrrolidine the title compound was obtained, i.e., 5-Phenyl-3- . At-azetidinomethyl.pyridine fumarate; M.p. 138-139°C (EtOAc) ; 1 H NMR (DMS0-d 6 , 300 MHz) : δ 8.86 (s, IH) , 8.58 (s, IH) , 8.12 (s, IH) , 7.72 (bd, J=8Hz, 2H) , 7.4-7.5 (m, 3H) , 6.58 (s, 2H) , 4.11 (s, 2H) , 3.70 (bt, J=7Hz, 4H) , 2.21 (quintet, J=7Hz, 4H) . Example 14 Radioligand Binding H-Nicotine binding to rat cerebral membranes was performed according to modifications of the method of Flyn and Mash (J . Neuroche . 42:1948 (1986)). 3 H-Nicotine (80 ci/mmol; New England Nuclear Corporation, Boston, MA) was used as the ligand for nicotinic acetylcholine receptor binding assays. All other reagents were purchased from the Sigma Chemical Co. (St. Louis, MO) . Male Sprague-Dawley rats (250 - 400 gm) were sacrificed by decapitation, the brains removed and the cerebral cortex dissected on ice. Synaptic membranes were prepared by homogenizing the cortical tissue in 20 volumes of ice-cold modified Tris buffer (50 mM Tris pH 7.4, 120 mM NaCl, 5 mM KC1, 2 mM EDTA, 1 mM PMSF) with a polytron (20 sec at setting 5-6) followed by centrifugation (15 min at 25,000 x g) at 4°C. The resultant pellet was rehomogenized and centrifuged twice. The final pellet was resuspended in ice-cold assay buffer (50 mM Tris pH 7.4, 120 mM NaCl, 5 mM KC1, 2 mM CaCl 2 , 1 mM MgCl 2 ) at a concentration of membrane equivalent to 1 gm wet weight cortex per 10 ml buffer. After protein determination the final membrane preparation was diluted with buffer to 3 mg protein/ml. This membrane preparation was used in either the fresh state or frozen (-70°C) then thawed. The binding assay is performed manually using 96-well plates, or using a Biomek automated work station (Beckman Instrument Co.). 3 H-Nicotine was diluted in assay buffer to give a final concentration of 1.9 nM. The Biomek automated work station was programmed to automatically transfer 750 μl of assay buffer with 3 H-nicotine, 230 μl of membrane preparation and 20 μl of solution containing the compound of interest in assay buffer, DMSO, ethanol:DMSO (1:1) or appropriate vehicle to the 96-well plate. Atropine was added to the incubation buffer at a final concentration of 3 μM to block binding to muscarinic acetylcholine receptor sites. The plates were maintained on ice for 60 min and the tissue-bound radioactivity was separated from the free by rapid filtration in a Brandel Harvester onto GF/C filters presoaked in 0.5% polyethyleneimine for at least 2 hr. The filters were washed with 4x2 ml of ice-cold assay buffer and filters were transferred to vials to which 4 ml of scintillation cocktail was added. The radioactivity was measured in a LS-6500 Beckman Liquid Scintillation Counter in an autodpm mode. Data were analyzed by log-logit transformation or non-linear regression analysis (e.g., employing GraphPad Prism, available from GraphPad Software, San Diego, CA) to give IC 50 values. Non-specific binding was defined by lOμM cytisine. The ability of invention compounds to displace H-QNB (quinuclidinyl benzilate; 43 Ci/mmol) from muscarinic acetylcholine receptors in rat cerebral membranes was also tested using the above-described method in which H-nicotine was replaced with 60 pM H-QNB, and atropine was excluded from the incubation buffer. The results of H-nicotine and H-QNB binding/displacment assays of several invention compounds are summarized in Table I. Table I As evidenced by the IC 50 values in the Table, each of the compounds tested was able to displace acetylcholine receptor ligands from their binding sites in rat cerebral membranes. Example 15 Neurotransmitter Release Measurement of H-dopamine release from rat striatal slices was performed according to the method of Sacaan et al. (J. Neurochem . 5_£:245 (1992)). Male Sprague- Dawley rats (250-300 g) were decapitated and the striata or olfactory tubercles dissected quickly on a cold glass surface. The tissue was chopped to a thickness of 300 μm with a Mcllwain tissue chopper. After chopping again at right angles the tissue was dispersed and incubated for 10 rain, at 37°C in oxygenated Kreb's buffer. H-Dopamine (40 Ci/mmol, NEN- Dupont, Boston, Ma) was added (50 nM) and the tissue was incubated for 30 min. in Kreb's buffer containing 10 μM pargyline and 0.5 mM ascorbic acid. Aliquots of the minced tissue were then transferred to chambers of a Brandel Superfusion system in which the tissue was supported on Whatman GF/B filter discs. The tissue was then superfused with buffer at a constant flow rate of 0.3 ml/min by means of a Brandel peristaltic pump. The perfusate was collected in plastic scintillation vials in 3-min fractions, and the radioactivity was estimated by scintillation spectrophotometry. The superfusate for the first 120 min was discarded. After two baseline fractions had been collected, the superfusion buffer was switched to fresh buffer with or without compound of interest. At the end of the experiment the filter and the tissue were removed, and the radiolabeled neurotransmitter content was estimated after extraction into scintillation fluid. The fractional efflux of radiolabeled neurotransmitter was estimated as the amount of radioactivity in the perfusate fraction relative to the total amount in the tissue. Following essentially the same procedure as set forth in the preceding paragraph, the amount of H-norepinephrine released from rat hippocampus, thalamus and prefrontal cortex slices superfused with buffer containing (or lacking) compounds of interest was also measured. The results of studies of the effects of an invention compound (as compared to the effect of nicotine) on the release of neurotransmitters from rat brain slices are presented in Table II. The results presented in the Table are expressed as the percent fractional release. Table II Ligand-stimulated HH--nneeuurroottransmitter Release in vitro from Slices of Different Rat Brain Regions Nicotine concentration 10 μM b Nicotine concentration 300 μM Nicotine concentration 100 μM. As shown in Table II, invention compound selectively induces release of catecholamines in different brain regions. While the invention has been described in detail with reference to certain preferred embodiments thereof, it will be understood that modifications and variations are within the spirit and scope of that which is described and claimed.

Claims: That which is claimed is: 1. A compound having the structure: I wherein: A is a l, 2, 3, 4, 5 or 6 atom bridging species linking C of the pyridine ring with N°, wherein A is selected from a straight chain or branched chain alkylene moiety having up to six atoms in the backbone thereof, or a substituted alkylene moiety, a straight chain or branched chain alkenylene moiety having up to six atoms in the backbone thereof, or a substituted alkenylene moiety, an alkynylene moiety having up to six atoms in the backbone thereof, or a substituted alkynylene moiety, -0-, -C(0)-, -C(S)-, -S-, -S(O)- and/or -S(O)-.-containing alkylene moiety; provided, however, that any heteroatom contained in A is separated from N° by at least two carbon atoms; and further provided that when A is a -C(O)- or -C(S)- containing alkylene moiety, at least one methylene unit intervenes between the -C(O)- or -C(S)- moiety of A and N α ; and further provided that N a is not conjugated with an alkenyl or alkynyl moiety, wherein A and B can optionally combine to form a monocyclic ring containing A, N a and B, wherein at least one methylene unit intervenes between such ring and C of the pyridine ring; B is a 1, 2, 3 or 4 atom bridging species linking N a with Z, wherein B is selected from a straight chain or branched chain alkylene moiety having up to four atoms in the backbone thereof, or a substituted alkylene moiety, a straight chain or branched chain alkenylene moiety having up to four atoms in the backbone thereof, or a substituted alkenylene moiety, an alkynylene moiety having up to four atoms in the backbone thereof, or a substituted alkynylene moiety, -0-, -C(O)-, -C(S)-, -I/(RV, -S-, -S(O)- and/or -S(0) 2 -containing alkylene moiety, wherein K is hydrogen or a lower alkyl moiety; provided, however, that any heteroatom contained in B is separated from N β by at least 2 carbon atoms, and further provided that when B is a -C(O)- or -C(S)- containing alkylene moiety, at least one methylene unit intervenes between the -C(O)- or -C(S)- moiety and N a ; and further provided that N a is not conjugated with an alkenyl or alkynyl moiety, and wherein B and R a can optionally combine to form a monocyclic ring containing B, R β and N ; Z is selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, hydroxyalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl. heterocyclic, substituted heterocyclic, 75 trifluoromethyl, cyano, cyanomethyl, nitro, carboxyl, carbamate, sulfonyl, sulfonamide, aryloxyalkyl, or -OR , wherein R z is hydrogen, lower alkyl or aryl, or Z is not present when A and B cooperate 80 to form a ring containing A, N a and B, or when R a and B cooperate to form a ring containing B, R a and N°; R β is selected from hydrogen or lower alkyl; and R , R , R and * R are each independently selected 85 from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, 90 substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic, trifluoromethyl, halogen, cyano, nitro; 95 -S(0)R', -S(0) 2 R', -S(0) 2 OR' or -S(0) 2 NHR', wherein each R' is independently hydrogen, lower alkyl, alkenyl, alkynyl or aryl; provided, however, that when R 2, R4, R5 or R is -S(0)R', R* is not hydrogen; and 100 further provided that when R' is alkenyl or alkynyl, the site of unsaturation is not conjugated with a heteroatom; -C(0)R", wherein R" is selected from hydrogen, alkyl, substituted alkyl, alkoxy, 105 alkylamino, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, aryloxy, arylamino, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, 110 substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic or trifluoromethyl, provided, however, that the carbonyl functionality is not conjugated with an 115 alkenyl or alkynyl functionality; -OR* ' ' or -NR' * ' 2 , wherein each R' • ' is independently selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, 120 alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, aroyl, 125 substituted aroyl, heterocyclic, substituted heterocyclic, acyl, trifluoromethyl, alkylsulfonyl or arylsulfonyl, provided, however, that the -OR' • * or -NR' ' ' 2 functionality is not conjugated with an 130 alkenyl or alkynyl functionality; -SR' • * ' , wherein R' ' ' ' is selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, 135 substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic or trifluoromethyl, 140 provided, however, that the -SR' ' ' * functionality is not conjugated with an alkenyl or alkynyl functionality; or -SiR 1 • ' ' ' 3 , wherein R' ' ' • ' is selected from alkyl or aryl; 145 provided, however, that the following compounds are excluded from the definition of Formula I: compounds wherein A is -CH=CH-(CH 2 ) 1 . 5 -CH 2 -, B is alkyl, Z is H or absent, R a is H, and each of R 2 , R 4 , R and R 6 are independently alkyl or halo; compounds wherein A is 150 - (CH 2 ) ■[-_.- • B and R a combine to form a B, R a , N a ring such that B and R° together are C 4 R 8 or C 5 R 10 , wherein R is hydrogen or alkyl, and Z is absent; compounds wherein A is -C(0)-(CH 2 ) 1 . 5 -, B is alkyl, Z is absent or H, R a is H or alkyl, and each of R , R 4 , R and R are alkyl or halo; 155 compounds wherein A is -CH 2 -, B is -CH 2 - or -CH 2 -CH 2 -, Z is H, R a is -CH 3 or -CH 2 -CH 3 , and each of R 2 , R 4 , R 5 and R 6 are hydrogen; compounds wherein A is -CH 2 -, B is -CH 2 -CH(CH 3 )-CH 2 -R, wherein R is para-tertiarybutylphenyl, Z is absent, R a is CH 3 or butyl, and each of R 2 , R 4 , R 5 and 160 R are hydrogen; compounds wherein A is -CH 2 -(CHR) n , wherein R is H or alkyl and n = 0 or 1, B is -(CH 2 ) n -CHR-CH(X)-, wherein R is H, methyl or ethyl, X is phenyl or substituted aryl (substitution selected from halogen, alkyl or alkoxy) , and n = 0 or 1, Z is phenyl or substituted aryl 165 (substitution selected from halogen, alkyl or alkoxy) , R a is _? . ~ t A H or alkyl, and each of R , R , R and R are selected from hydrogen, alkyl or alkenyl; compounds wherein A is -CH(CH 3 )-, B is -CH 2 -, -CH 2 -C 6 H 4 - or -CH 2 -C 1fJ H 6 -, Z is hydrogen, -C 6 H 5 , or -C 1fJ H 7 , R a is CH 3 , and each of R , R , R 170 and R are hydrogen; compounds wherein A is -CH(CH 3 )-, B is -(CH 2 )-, Z is hydrogen, Ra is hydrogen, and each of R2, R4, R and R are hydrogen; compounds wherein A is -CH(CH 3 )-, B is -CH 2 -CH 2 -[2,3-(OR) 2 C 6 H 3 ] , wherein R is methyl or benzyl, and R a is hydrogen, or B and R a combine to form a B, R a , N β 175 ring such that B and R a together are -C(=CH 2 )-[l,2-(3,4(OR) 2 benzo]-CH 2 CH 2 -, wherein R is methyl or benzyl, Z in all instances is absent, and each of R 2, R4, R5 and R are hydrogen; as well as compounds wherein A is -CH(CH 3 )- or -CH 2 -CH 2 -CH 2 -, B is -CH 2 -CH 2 -CH(C 6 H 5 )- or 180 -CH(CH 3 )-C 6 H 5 , Z is phenyl or absent, R β is hydrogen, and each of R , R , R and R are hydrogen. 2. A compound according to claim l wherein A is selected from: -CR 2 -, wherein each R is independently selected from hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, alkenyl, substituted alkenyl, alkynyl or substituted alkynyl; -(cycloalkyl)-, or -C(=CXY)-CH 2 -, wherein X and Y are each independently selected from hydrogen, lower alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl," hydroxyalkyl, halogen, trifluoromethyl, cyano, cyanomethyl, nitro, carboxyl, carbamate, sulfonyl, sulfonamide, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, heterocyclic, substituted heterocyclic, aarryyllooxxyyaalkyl, or -OR AA, wherein RAA is lower alkyl or aryl. 3. A compound according to claim 2 wherein X and Y are not both -OR AA . 4. A compound according to claim 1 wherein A and B combine to form a ring including A, N a and B. 5. A compound according to claim 4 wherein the combination of A and B is selected from -0-CH 2 CH(CH 2 ) n -, wherein n falls in the range of 1 up to 4. 6. A compound according to claim 1 wherein B is selected from -CH 2 -, -CH 2 CH 2 -, -CH 2 CH 2 -C(0)-, -CH 2 CH 2 C(0)NH-, -CH 2 -CH=CH-, or -CH 2 -C≡C-. 7. A compound according to claim 1 wherein B and R α combine to form a ring including R α , N a and B. 8. A compound according to claim 7 wherein the combination of B and R a is selected from -CH 2 CH 2 CH 2 -, -CH 2 CH 2 CH 2 CH 2 - or -CH 2 CH 2 CH 2 CH 2 CH 2 -. 9. A compound according to claim 1 wherein R β is hydrogen or methyl. 10. A compound according to claim 1 wherein R 2 i.s hydrogen. 11. A compound according to claim 1 wherein R 4 i.s selected from hydrogen, aryl, alkoxy or aryloxy. 12. A compound according to claim 1 wherein R is selected from alkynyl, aryl, substituted aryl, trialkylsilyl, arylalkyl, arylalkenyl or arylalkynyl. 13. A compound according to claim 1 wherein R is selected from hydrogen, chlorine, amino, methyl or alkoxy. 14. A compound according to claim 1 wherein said compound is substantially optically pure. 15. A compound according to claim 1 wherein said compound is a racemic mixture or a diasteromeric mixture. 16. A compound according to claim 1 wherein: A = -CH 2 -, B and R a combined = -CH 2 CH 2 CH 2 CH 2 -, Z = not present, R 2 , R 4 , and R 6 = hydrogen, and R = phenyl. 17. A compound according to claim 1 wherein: A = -CH 2 -, B and R β combined = -CH 2 CH 2 CH 2 CH 2 -, Z = not present, ~ * L. A R , R , and R = hydrogen , and R = parahydroxyphenyl . 18 . A compound according to claim 1 wherein : A = -CH 2 - , B and R a combined = -CH 2 CH 2 CH 2 CH 2 - , Z = not present, R , R , and R = hydrogen , and R = 3-chloro-4-hydroxyphenyl . 19 . A compound according to claim 1 wherein : A = -CH 2 - , B and R a combined = -CH 2 CH 2 CH 2 CH 2 - , Z = not present, R 2, R4, and R6 = hydrogen, and R 5 = -C≡C-H. 20. A compound according to claim 1 wherein: A = -CH 2 -, B and R a combined = -CH 2 CH 2 CH 2 -, Z = not present, R 2, R4, and R6 = hydrogen, and R = phenyl. 21. A compound according to claim l wherein: A = -CH(CH 3 )-, B = -CH 2 -, Z = hydrogen, R a = methyl, and R , R , R and R = hydrogen. 22. A compound according to claim 1 wherein: A = -C(CH 3 ) 2 -, B = -CH 2 -, Z = hydrogen, R a = methyl, and R , R , R and R = hydrogen. 23. A compound according to claim 1 wherein: A = -(spirocyclopropyl)-, B = -CH 2 -, Z = hydrogen, R a = methyl, and R , R , R and R = hydrogen. 24. A compound according to claim 1 wherein: A = -CH 2 CH 2 -, B and R a combined = -CH 2 CH 2 CH 2 CH 2 -, Z = not present, and R , R , R and R = hydrogen. 25. A compound according to claim 1 wherein: A = -C(=CXY)CH 2 -, wherein X and Y are each independently selected from hydrogen, lower alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, hydroxyalkyl, halogen, trifluoromethyl, cyano, cyanomethyl, nitro, carboxyl, carbamate, sulfonyl, sulfonamide, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, heterocyclic, substitutedheterocyclic, aryloxyalkyl, or -OR AA, wherein RAA is lower alkyl or aryl, B and R a combined = -CH 2 CH 2 CH 2 CH 2 -, Z = not present, and R , R , R and R = hydrogen. 26. A compound according to claim 25 wherein X ΔA and Y are not both -OR . 27. A compound according to claim 1 wherein: A = -CH 2 -, B — —CHCH 2 —, Z = 3,4-benzopyrrolidine, R a = methyl, and R , R , R , and R = hydrogen . 28 . A compound according to claim 1 wherein : A and B combined = -0-CH 2 CHCH 2 CH 2 CH 2 - , thereby forming a ring including A, N β and B, Z = not present. R = methyl, and R , RR 5 ,, aanndd RR 6 are independently selected from the group seitt ffoorrtthh aabboovvee,, wvith tthhee pprroovviissoo tthhaatt RR ,, RR ,, RR ,, aanndd RR aarree not hydrogen, alkyl, alkoxy or halogen. 29. A compound according to claim 1 wherein: A = -CH 2 -, B = -CH 2 -C≡C-, Z = hydrogen, R a = methyl, R , R , R , and R = hydrogen. 30. A compound according to claim 1 wherein: A = -CH 2 CH(CH 3 )-, B = -CH 2 -C≡C-, Z = hydrogen, R a = methyl, R , R , R , and R = hydrogen. 31. A compound according to claim 1 wherein: A = -CH 2 -, B = -CH 2 -CH=C(X)-, wherein X is selected from hydrogen, lower alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, hydroxyalkyl, halogen, trifluoromethyl, cyano, cyanomethyl, nitro, carboxyl, carbamate, sulfonyl, sulfonamide, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, heterocyclic, substitutedheterocyclic, aryloxyalkyl, or -OR , wherein R is lower alkyl, or aryl, Z = lower alkyl, hydroxyalkyl, cyano, trifluoromethyl, cyanomethyl, nitro, carboxyl, carbamate, sulfonyl, aryl, sulfonamide, aryloxyalkyl, or -OR , wherein R is lower alkyl or aryl, R = methyl, and R , R , R , and R = hydrogen. 32. A compound according to claim 31, with the proviso that when X is -ORx, Z i.s not -ORZ. 33. A compound according to claim 1 wherein: A = -CH 2 -, B = —CHCH 2 —, Z = phenyl or substituted phenyl. R = methyl, and R , R , R , and R = hydrogen. 34. A compound according to claim 1 wherein: A = -CH 2 -, B = —CHCH 2 —, Z = furanyl or substituted furanyl, R a = methyl, and R , R , R , and R = hydrogen. 35. A compound according to claim 1 wherein: A = -CH 2 -, B = —CHCH 2 _ , Z = imidazolyl, R a = methyl, and R = hydrogen. 36. A compound according to claim 1 wherein: A = -CH 2 -, B = -CH 2 CH 2 -C(0)-, Z = phenyl or substituted phenyl, R α = methyl, and R , R , R , and R = hydrogen. 37. A compound according to claim 1 wherein: A - -CH(CH 3 )-, B = -CH 2 -, Z = hydrogen, R a = hydrogen or methyl, and R , R , R , and R = hydrogen. 38. A compound according to claim 1 wherein: A = -CH(CH 3 )-, B = -CH(CH 3 )CH 2 -, Z = hydrogen, R a , R , R , R , and R 6 = hydrogen. 39. A compound according to claim 1 wherein: A = -CH(CH 3 )-, B = -(cyclopropyl)-, Z = hydrogen, R a , R 2 , R , R , and R = hydrogen. 40. A compound according to claim 1 wherein: A = -CH 2 -, B = -(cyclopropyl)-, Z = hydrogen, R a = hydrogen or methyl, and ? __. *_ A R , R , R , and R = hydrogen. 41. A compound according to claim 1 wherein: A = -CH 2 -, Z = phenyl, R a = hydrogen or methyl, and R , R , R , and R = hydrogen. 42. A pharmaceutical composition comprising a compound of the structure: I wherein: A is a l, 2, 3, 4, 5 or 6 atom bridging species linking C of the pyridine ring with N a , wherein A is selected from a straight chain or branched chain alkylene moiety having up to six atoms in the backbone thereof, or a substituted alkylene moiety, a straight chain or branched chain alkenylene moiety having up to six atoms in the backbone thereof, or a substituted alkenylene moiety, an alkynylene moiety having up to six atoms in the backbone thereof, or a substituted alkynylene moiety, -0-, -C(O)-, -C(S)-, -S-, -S(0)- and/or -S(O) 2 -containing alkylene moiety; provided, however, that any heteroatom contained in A is separated from N a by at least two carbon atoms; and further provided that when A is a -C(O)- or -C(S)- containing alkylene moiety, at least one methylene unit intervenes between the -C(O)- or -C(S)- moiety of A and N a ; and further provided that N a is not conjugated with an alkenyl or alkynyl moiety, wherein A and B can optionally combine to form a monocyclic ring containing A, N a and B, wherein at least one methylene unit intervenes between such ring and C of the pyridine ring; B is a 1, 2, 3 or 4 atom bridging species linking N a with Z, wherein B is selected from a straight chain or branched chain alkylene moiety having up to four atoms in the backbone thereof, or a substituted alkylene moiety, a straight chain or branched chain alkenylene moiety having up to four atoms in the backbone thereof, or a substituted alkenylene moiety, an alkynylene moiety having up to four atoms in the backbone thereof, or a substituted alkynylene moiety, -0-, -C(O)-, -C(S)-, -NW)-, -S-, -S(0)- and/or -S(0) 2 -containing alkylene moiety, wherein K is hydrogen or a lower alkyl moiety; provided, however, that any heteroatom contained in B is separated from N° by at least 2 carbon atoms, and further provided that when B is a -C(O)- or -C(S)- containing alkylene moiety, at least one methylene unit intervenes between the -C(O)- or -C(S)- moiety and N α ; and further provided that N a is not conjugated with an alkenyl or alkynyl moiety, and wherein B and R° can optionally combine to form a monocyclic ring containing B, R a and N°; Z is selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, hydroxyalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, 75 heterocyclic, substituted heterocyclic, trifluoromethyl, cyano, cyanomethyl, nitro, carboxyl, carbamate, sulfonyl, sulfonamide, aryloxyalkyl, or -OR , wherein R is hydrogen, lower alkyl or aryl, or 80 z is not present when A and B cooperate to form a ring containing A, N β and B, or when R a and B cooperate to form a ring containing B, R a and N β ; R ,a is selected from hydrogen or lower alkyl; and 85 R , R , R and * R are each independently selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, 90 substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic, trifluoromethyl, 95 halogen, cyano, nitro; -S(0)R', -S(0) 2 R', -S(0) 2 OR' or -S(0) 2 NHR', wherein each R' is independently hydrogen, lower alkyl, alkenyl, alkynyl or aryl; provided, however, that when R 2, R4, R5 100 or R is -S(0)R', R' is not hydrogen; and further provided that when R' is alkenyl or alkynyl, the site of unsaturation is not conjugated with a heteroatom; -C(0)R", wherein R" is selected from 105 hydrogen, alkyl, substituted alkyl, alkoxy, alkylamino, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, aryloxy, arylamino, alkylaryl, substituted alkylaryl, arylalkyl, 110 substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic or trifluoromethyl, provided, however, that the carbonyl 115 functionality is not conjugated with an alkenyl or alkynyl functionality; -OR' ' ' or -NR' • ' 2 , wherein each R' • ' is independently selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted 120 cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, 125 arylalkynyl, substituted arylalkynyl, aroyl, substituted aroyl, heterocyclic, substituted heterocyclic, acyl, trifluoromethyl, alkylsulfonyl or arylsulfonyl, provided, however, that the -OR • • • or -NR • ' ' 2 130 functionality is not conjugated with an alkenyl or alkynyl functionality; -SR' * ' ' , wherein R' ' ' ' is selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted 135 alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, 140 substituted heterocyclic or trifluoromethyl, provided, however, that the -SR' • • ' functionality is not conjugated with an alkenyl or alkynyl functionality; or -SiR' ' ' ' ' 3 , wherein R' ' ' ' ' is selected 145 from alkyl or aryl; provided, however, that the following compounds are excluded from the definition of Formula I: compounds wherein A is -CH=CH-(CH 2 )ι- 5 -CH 2 -, B is alkyl, Z is H or absent, R α is H, and each of R , R , R and R are 150 independently alkyl or halo; compounds wherein A is ~(CH 2 ) 1 . 5 -, B and R α combine to form a B, R a , N a ring such that B and R a together are C 4 R 8 or C 5 R 10 , wherein R is hydrogen or alkyl, and Z is absent; compounds wherein A is -C(0)-(CH 2 ) 1 . 5 -, B is alkyl, Z is absent or H, R β is H or 155 alkyl, and each of R 2 , R 4 , R 5 and R 6 are alkyl or hale- compounds wherein A is -CH 2 -, B is -CH 2 - or -CH 2 -CH 2 -, Z is H, R a is -CH 3 or -CH 2 -CH 3 , and each of R 2 , R 4 , R 5 and R 6 are hydrogen; compounds wherein A is -CH 2 -, B is -CH 2 -CH(CH 3 )-CH 2 -R, wherein R is para-tertiarybutylphenyl, 160 Z is absent, R α is CH 3 or butyl, and each of R 2 , R 4 , R 5 and R are hydrogen; compounds wherein A is -CH 2 -(CHR) n , wherein R is H or alkyl and n = 0 or 1, B is -(CH 2 ) n -CHR-CH(X)-, wherein R is H, methyl or ethyl, X is phenyl or substituted aryl (substitution selected from halogen, alkyl or alkoxy) , 165 and n = 0 or l, Z is phenyl or substituted aryl (substitution selected from halogen, alkyl or alkoxy) , R β is H or alkyl, and each of R , R 4 , R and R are selected from hydrogen, alkyl or alkenyl; compounds wherein A is -CH(CH 3 )-, B is -CH 2 -, -CH 2 -C 6 H 4 - or -CH 2 -C 1fJ H 6 -, Z is 170 hydrogen, -C 6 H 5 , or -C 10 H 7 , R a is CH 3 , and each of R 2 , R 4 , R 5 and R are hydrogen; compounds wherein A is -CH(CH 3 )-, B is -(CH 2 )-, Z is hydrogen, R a is hydrogen, and each of R , R , R and R are hydrogen; compounds wherein A is -CH(CH 3 )-, B is -CH 2 -CH 2 -[2,3-(OR) 2 C 6 H 3 ] , wherein R is methyl or benzyl, 175 and R a is hydrogen, or B and R a combine to form a B, R α , N a ring such that B and R a together are -C(=CH 2 )-[l,2-(3,4(OR) 2 benzo]-CH 2 CH 2 -, wherein R is methyl or benzyl, Z in all instances is absent, and each of R , R , R and R are hydrogen; as well as compounds wherein A is 180 -CH(CH 3 )- or -CH 2 -CH 2 -CH 2 -, B is -CH 2 -CH 2 -CH(C 6 H 5 )- or -CH(CH 3 )-C 6 H 5 , Z is phenyl or absent, R a is hydrogen, and each of R 2 , R 4 , R 5 and R 6 are hydrogen. 43. Use of a compound having the structure: wherein: A is a l, 2, 3, 4, 5 or 6 atom bridging species linking C of the pyridine ring with N a , wherein A is selected from a straight chain or branched chain alkylene moiety having up to six atoms in the backbone thereof, or a substituted alkylene moiety, a straight chain or branched chain alkenylene moiety having up to six atoms in the backbone thereof, or a substituted alkenylene moiety, an alkynylene moiety having up to six atoms in the backbone thereof, or a substituted alkynylene moiety, -0-, -C(0)-, -C(S)-, -S-, -S(0)- and/or -S(0) 2 -containing alkylene moiety; provided, however, that any heteroatom contained in A is separated from N° by at least two carbon atoms; and further provided that when A is a -C(0)- or -C(S)- containing alkylene moiety, at least one methylene unit intervenes between the -C(0)- or -C(S)- moiety of A and N a ; and further provided that N α is not conjugated with an alkenyl or alkynyl moiety, wherein A and B can optionally combine to form a monocyclic ring containing A, N a and B, wherein at least one methylene unit intervenes between such ring and C of the pyridine ring; B is a 1, 2, 3 or 4 atom bridging species linking N α with Z, wherein B is selected from a straight chain or branched chain alkylene moiety having up to four atoms in the backbone thereof, or a substituted alkylene moiety, a straight chain or branched chain alkenylene moiety having up to four atoms in the backbone thereof, or a substituted alkenylene moiety, an alkynylene moiety having up to four atoms in the backbone thereof, or a substituted alkynylene moiety, -0-, -C(O)-, -C(S)-, --Λ , -S-, -S(O)- and/or -S(0) 2 -containing alkylene moiety, wherein R^ is hydrogen or a lower alkyl moiety; provided, however, that any heteroatom contained in B is separated from N σ by at least 2 carbon atoms, and further provided that when B is a -C(O)- or -C(S)- containing alkylene moiety, at least one methylene unit intervenes between the -C(O)- or -C(S)- moiety and N a ; and further provided that N a is not conjugated with an alkenyl or alkynyl moiety, and wherein B and R a can optionally combine to form a monocyclic ring containing B, R β and N a ; Z is selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, hydroxyalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic, 75 trifluoromethyl, cyano, cyanomethyl, nitro, carboxyl, carbamate, sulfonyl, sulfonamide, aryloxyalkyl, or -OR , wherein R is hydrogen, lower alkyl or aryl, or Z is not present when A and B cooperate 80 to form a ring containing A, N β and B, or when R a and B cooperate to form a ring containing B, R a and N β ; R α is selected from hydrogen or lower alkyl; and R , R , R and R are each independently selected 85 from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, 90 substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic, trifluoromethyl, halogen, cyano, nitro; 95 -S(0)R', -S(0) 2 R', -S(0) 2 OR' or -S(0) 2 NHR', wherein each R' is independently hydrogen, lower alkyl, alkenyl, alkynyl or aryl; provided, however, that when R 2, R4, R5 or R is -S(0)R', R* is not hydrogen; and 100 further provided that when R' is alkenyl or alkynyl, the site of unsaturation is not conjugated with a heteroatom; -C(0)R", wherein R" is selected from hydrogen, alkyl, substituted alkyl, alkoxy, 105 alkylamino, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, aryloxy, arylamino, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, 110 substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic or trifluoromethyl, provided, however, that the carbonyl functionality is not conjugated with an 115 alkenyl or alkynyl functionality; -OR' ' ' or -NR' • ' 2 , wherein each R 1 • ' is independently selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, 120 alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, aroyl, 125 substituted aroyl, heterocyclic, substituted heterocyclic, acyl, trifluoromethyl, alkylsulfonyl or arylsulfonyl, provided, however, that the -OR ■ ' • or -NR' ' ' 2 functionality is not conjugated with an 130 alkenyl or alkynyl functionality; -SR' * ' ' , wherein R' ' * • is selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, alkylaryl, 135 substituted alkylaryl, arylalkyl, substituted arylalkyl, arylalkenyl, substituted arylalkenyl, arylalkynyl, substituted arylalkynyl, heterocyclic, substituted heterocyclic or trifluoromethyl, 140 provided, however, that the -SR* ' • • functionality is not conjugated with an alkenyl or alkynyl functionality; or -SiR' "" 3 , wherein R' • ' ' ' is selected from alkyl or aryl; 145 provided, however, that the following compounds are excluded from the definition of Formula I: compounds wherein A is -CH=CH-(CH 2 )ι- 5 -CH 2 -, B is alkyl, Z is H or absent, R is H, and each of R , R , R and R are independently alkyl or halo; compounds wherein A is 150 -(CH^. j -, B and R a combine to form a B, R°, N a ring such that B and R a together are C 4 R 8 or C 5 R 10 , wherein R is hydrogen or alkyl, and Z is absent; compounds wherein A is -C(0)-(CH 2 ),. 5 -, B is alkyl, Z is absent or H, R α is H or alkyl, and each of R , R , R and R are alkyl or halo; 155 compounds wherein A is -CH 2 -, B is -CH 2 - or -CH 2 -CH 2 -, Z is H, R β is -CH 3 or -CH 2 -CH 3 , and each of R , R , R and R are hydrogen; compounds wherein A is -CH 2 -, B is -CH 2 -CH(CH 3 )-CH 2 -R, wherein R is para-tertiarybutylphenyl, Z is absent, R a is CH 3 or butyl, and each of R 2 , R 4 , R 5 and 160 R are hydrogen; compounds wherein A is -CH 2 -(CHR) n , wherein R is H or alkyl and n = 0 or 1, B is -(CH 2 ) n -CHR-CH(X)-, wherein R is H, methyl or ethyl, X is phenyl or substituted aryl (substitution selected from halogen, alkyl or alkoxy) , and n = 0 or 1, Z is phenyl or substituted aryl 165 (substitution selected from halogen, alkyl or alkoxy) , R a is A C . H or alkyl, and each of R , R , R and R are selected from hydrogen, alkyl or alkenyl; compounds wherein A is -CH(CH 3 )-, B is -CH 2 -, -CH 2 -C 6 H 4 - or -CH 2 -C 10 H 6 -, Z is hydrogen, -C 6 H 5 , or -C 10 H 7 , R a is CH 3 , and each of R 2 , R 4 , R 170 and R are hydrogen; compounds wherein A is -CH(CH 3 )-, B is -(CH 2 )-, Z is hydrogen, R a is hydrogen, and each of R 2 , R 4 , R and R are hydrogen; compounds wherein A is -CH(CH 3 )-, B is -CH 2 -CH 2 -[2,3-(OR) 2 C 6 H 3 ] , wherein R is methyl or benzyl, and R α is hydrogen, or B and R α combine to form a B, R α , N a 175 ring such that B and R a together are -C(=CH 2 )-[1,2-(3,4 (OR) 2 benzo]-CH 2 CH 2 -, wherein R is methyl or benzyl, Z in all instances is absent, and each of R 2, R4, R5 and R are hydrogen; as well as compounds wherein A is -CH(CH 3 )- or -CH 2 -CH 2 -CH 2 -, B is -CH 2 -CH 2 -CH(C 6 H 5 )- or 180 -CH(CH 3 )-C 6 H 5 , Z is phenyl or absent, R a is hydrogen, and each of R , R , R and R are hydrogen; or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for modulating the activity of acetylcholine receptors. 44. A method of modulating the activity of acetylcholine receptors, said method comprising: contacting cell-associated acetylcholine receptors with a sufficient concentration of a compound according to claim 1 to modulate the activity of said acetylcholine receptors. 45. Method for treating Parkinson's disease, said method comprising administering a therapeutically effective amount of a compound according to claim 1 to a patient suffering from Parkinson's disease. 46. Method for treating Alzheimer's disease, said method comprising administering a therapeutically effective amount of a compound according to claim 1 to a patient suffering from Alzheimer's disease. 47. Method for treating dementia, said method comprising administering a therapeutically effective amount of a compound according to claim 1 to a patient suffering from dementia. 48. Method for controlling pain, said method comprising administering a pain-reducing amount of a compound according to claim 1 to a patient suffering from pain. 49. A method for the preparation of compounds according to claim 1 having the structure I, wherein each of A, B, Z, R a , R , R , R , and R are as defined above, said method comprising contacting an acyl pyridine of Formula II: II with a primary amine having the structure N H 2 BZ under conditions suitable to produce an imine of Formula III: III reducing imine III to produce secondary amine IV: IV and optionally alkylating amine of Formula IV to produce a tertiary amine of structure V: N B — Z R α 50. A method for the preparation of compounds according to claim 1 having the structure I, wherein each of A, B, Z, R a , R , R , R , and R are as defined above. said method comprising contacting pyridylamine VI with ketone VII under reductive amination conditions, wherein pyridylamine VI and ketone VII have the structures: ITHR β VI VII. 51. A method for the preparation of compounds according to claim 1 having the structure I, wherein each of A, B, Z, R α , R , R , R , and R 6 are as defined above, said method comprising contacting pyridylketone IX with amine X under reductive amination conditions, wherein pyridylketone IX and amine X have the structures: 52. A method for the preparation of compounds according to claim 1 having the structure XIII, or amide derivatives thereof, wherein XIII has the structure: XIII wherein each of A, B, Z, R°, R , R , R , and R are as defined above, said method comprising contacting a nicotinic acid derivative having the structure XI with amine X under condensation conditions suitable to form amide XII, and thereafter optionally reducing said amide to an amine having the structure XIII, wherein X, XI and XII have the following structures: HN° — B — Z XI XII. 53. A method for the preparation of compounds according to claim 1 having the structure XVI: XVI wherein each of A, B, Z, R a , R , R , R , and R are as defined above, said method comprising contacting hydroxypyridine XIV with hydroxylamine XV under Mitsunobu coupling conditions, wherein hydroxypyridine XIV and hydroxylamine XV have the structures: XIV HO — XV. 54. A method for the preparation of compounds according to claim 1 having the structure XIX, wherein XIX has the structure: XIX wherein each of A, B, Z, R α , R , R , R , and R are as defined above, said method comprising contacting substituted pyridine XVII with acid XX under condensation conditions suitable to produce pyridine XVIII, and thereafter optionally reducing pyridine XVIII to produce XIX, wherein pyridine XVII, acid XX and pyridine XVIII have the following structures: XVII XX XVIII 55. A method for the preparation of compounds according to claim 1 having the structure XIX, wherein XIX has the structure: XIX wherein each of A, B, Z, R a , R , R , R , and R are as defined above, said method comprising subjecting ketone XXI to reductive amination conditions in the presence of substituted pyridine XVII, wherein ketone XXI and substituted pyridine XVII have the following structures: R. Q'Z XXI XVII 56. A method for the preparation of compounds according to claim 1 having the structure I, wherein each ooff AA,, BB,, ZZ,, RR aa ,, RR 22 ,, R 4 , R , and R are as defined above, said method comprising contacting hydroxypyridine XXII with an activating agent, and thereafter displacing the activated hydroxy1 group of XXII with amine X, wherein hydroxypyridine XXII and amine X have the structure: XXII HN — B — Z 20 X.

Inventors: COSFORD NICHOLAS D, VERNIER JEAN-MICHEL, COSFORD, NICHOLAS, D., VERNIER, JEAN-MICHEL
Applicants: COSFORD NICHOLAS D, SIBIA NEUROSCIENCES INC, VERNIER JEAN MICHEL, COSFORD, NICHOLAS, D., SIBIA NEUROSCIENCES, INC., VERNIER, JEAN-MICHEL
Application year: 1996
Main classification: C07D213
IPC codes: A61K31, A61P25, A61P43, C07D213, C07D401, C07F7