Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds

Abstract: The present invention relates to quinoline-4-carbonylguanidine derivative represented by formula (1) and pharmaceutically acceptable salt thereof, a process for producing the same, and a Na + /H + exchanger inhibitor containing the compound as an active ingredient. The compounds of the present invention are useful as an agent for treating or preventing various diseases by hyperfunction of the Na + /H + exchanger and as a diagnostic agent for these diseases.

Description: The present invention relates to novel quinoline-4-carbonylguanidine derivatives or pharmaceutically acceptable salts thereof. More specifically, the present invention relates to an agent which contains the above-mentioned compounds and which is particularly useful as an inhibitor of an Na + /H + exchanger (hereinafter referred to as "NHE") for treating or preventing e.g. hypertension, arrhythmia, myocardial infarction, angina pectoris, arteriosclerosis, diabetic complication, fibrosis of lung, liver or kidney, cell growth of vascular smooth muscle, cardiac muscle or prostate, and cancers, a protective solution of internal organs cut from the body for transplantation or internal organs transplanted, and a diagnostic agent. It has been known that when the pH in cells changes, activity of enzymes or ion channels in cells changes, which greatly influences physiological functions of cells. Accordingly, a mechanism of regulating intracellular pH has been long studied, and the presence of various ion exchangers that contribute to maintenance of homeostasis of intracellular pH in cells has been clarified. NHE is one of these systems, and a variety of physiological functions such as regulation of the pH in cells, cell volume and cell growth have become known. In recent years, it has become clear through experiments that hormons, growth factors and intracellular acidosis activate NHE and result in a cytoplasmic alkalinization [Cir. Res., 57 , 773 - 788 (1985)]. These NHE activators attract attention as factors that cause various diseases, and studies for clarifying the relationship between enhanced NHE activity and these diseases are now assiduously being conducted. With respect to study reports concerning NHE, there are general reports, such as Cir. Res., 57 , 773 - 788 (1985) and Hypertension, 21 , 607 - 617 (1993). Recently, it has been reported that NHE is activated in myocardial ischemia and reperfusion [Cir. Res., 66 , 1156 - 1159 (1990)], and that inhibition of NHE is effective for preventing disorders caused by myocardial ischemia and the consequential arrhythmia [Cir. Res., 73 , 269 - 275, (1993)]. Accordingly, the NHE inhibitor is useful for preventing or treating angina pectoris and myocardial infarction, ischemic arrhythmia, reperfusion arrhythmia, organ disorders following ischemia and reperfusion, cerebral ischemic disorders, cerebral apoplexy and ischemic diseases of limbs and peripheral organs. Further, it is useful as an agent for myocardial protection and organ protection under anoxic condition and reperfusion state in surgical operation or transplantation of internal organs, or as an ingredient of a protective solution for treating or preventing disorders of internal organs cut from the body for transplantation or internal organs transplanted. The relationship between NHE activity and hypertension has attracted attention so far. Recently, hyperfunction of NHE has been observed in cells such as platelets, erythrocytes and leukocytes of patients suffering from essential hypertension [Hypertension, 21 , 607 - 617 (1993)], and the relationship between NHE and hypertension has been clarified. Further, it has been reported that in many cells, NHE participates in cell growth through inclusion of Na + into cells and intracellular alkalinization , and that amiloride having NHE inhibitory activity suppresses cardiac hypertrophy [Circulation, 86 (Suppl. I) I-177 (1992)]. That is, it is suggested that the NHE inhibitor is useful as an agent for preventing or treating diseases caused by excessive cell growth with an enhanced NHE activity, such as arteriosclerosis, vascular restenosis after percutaneous transluminal coronary angioplasty (PTCA) associated with a proliferation of vascular smooth muscle cells, rheumatoid arthritis with a proliferation of synovial cells, renal glomerulosclerosis with a proliferation of mesangial cells, pulmonary, hepatic and renal fibrosis with a proliferation of fiblobrasts, diabetic complication caused by vascularization, cardiac hypertrophy or prostatic hypertrophy, and cancers [Cir. Res., 57 , 773 - 788 (1985), Proc. Natl. Acad. Sci. USA., 86 , 4525 - 4529 (1989), and Cir. Res., 73 , 269 - 275 (1993)]. Still further, the relationship between activation of NHE and inflammation has been reported [Am. J. Physiol., 267, C1623 - C1632 (1994)], and the NHE inhibitor is useful as an agent for treating or preventing diseases caused by infiltration of leukocytes associated with enhanced NHE activity, such as inflammation. As stated above, it has been known that NHE activity is enhanced in various states of NHE. The NHE activity can easily be measured by using a strong NHE inhibitor to easily obtainable cells such as platelets, erythrocytes and leukocytes. That is, the NHE inhibitor is also useful as a diagnostic agent for hypertension, diseases caused by cell growth or diabetes. Amiloride derivatives containing a guanidinocarbonyl group have been used in animal tests as an NHE inhibitor so far. It has been reported that these compounds suppress simultaneously Na + (sodium ion) channels and an Na + /Ca + (sodium ion/calcium ion) exchanger in concentrations in which they suppress NHE, and with respect to the NHE inhibitory activity, IC 50 (50 % inhibitory concentration) is approximately 100 µM which is not satisfactory [J. Membrane, Biol., 105 , 1-21 (1988)]. The above-mentioned amiloride derivatives and benzoylguanidine derivatives [JP A 3-106858 (Family: EP416499); hereinafter "JP A" means Publication of Japanese Patent Application] which are monocyclic compounds have been known as an NHE inhibitor. On the other hand, isoquinoline derivatives [JP A 6-211799 (Family: EP590455)], indole derivatives [JP A 7-10839 (Family: EP622356)] and quinoline derivatives (EP682017) have been known as compounds having a fused ring. The quinoline derivatives described in EP682017 are compounds containing a guanidinocarbonyl group in the 3-position. With respect to the NHE inhibitory activity, IC 50 is several micromoles, and it is not satisfactory. EP112776 discloses phenyl-2-quinoline-4-carboxamide derivatives useful for the treatment of cardiovascular diseases. W09426709 discloses 3-phenylbenzoylguanidine derivatives as inhibitors of Na + /H + exchange in cells. It is an object of the present invention to provide compounds which have strong NHE inhibitory activity and which are useful as an agent for preventing or treating various diseases caused by hyperfunction of NHE and as a diagnostic agent. This object could be achieved on the basis of the finding that quinoline-4-carbonylguanidine derivatives having a phenyl group in the 2-position have strong NHE inhibitory activity. That is, the present invention relates to: [1] A quinoline-4-carbonylguanidine derivative represented by formula (1) wherein R 1 , R 2 , R 3 and R 4 are the same or different and each represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a halogen atom, a nitro group, an amino group, a hydroxyl group, an alkyloxy group having from 1 to 6 carbon atoms, an alkyloxy group having from 1 to 6 carbon atoms and containing a terminal alkyloxy group having from 1 to 6 carbon atoms, an alkylsulfonylamino group having from 1 to 6 carbon atoms, or an alkanoylamino group having from 2 to 6 carbon atoms, X 1 , X 2 , X 3 , X 4 and X 5 are the same or different and each represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a halogen atom, a nitro group, an amino group, a hydroxyl group, a trifluoromethyl group, an alkyloxy group having from 1 to 6 carbon atoms, an alkyloxy group having from 1 to 6 carbon atoms and containing a terminal alkyloxy group having from 1 to 6 carbon atoms, or a trifluoromethoxy group, and Y represents a hydrogen atom, or an alkyl group having from 1 to 6 carbon atoms, or a pharmaceutically acceptable salt thereof. [2] The quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in [1], wherein one or two of R 1 , R 2 , R 3 and R 4 represent an alkyloxy group having from 1 to 6 carbon atoms. [3] The quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in [1], wherein X 1 represents a methyl group. [4] The quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in [2], wherein X 1 represents a methyl group. [5] A process for producing the quinoline-4-carbonylguanidine derivative of [1], [2], [3] or [4], which comprises reacting a quinoline-4-carboxylic acid derivative represented by formula (2) wherein L represents a hydroxyl group, or a leaving group that can easily be substituted by means of a nucleophilic reagent, and R 1 , R 2 , R 3 , R 4 , X 1 , X 2 , X 3 , X 4 , X 5 and Y are as defined in formula (1) with guanidine. [6] A pharmaceutical composition containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in [1], [2], [3] or [4]. [7] A Na + /H + exchanger inhibitor containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in [1], [2], [3] or [4]. [8] An agent for treating or preventing hypertension, the agent containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in [1], [2], [3] or [4]. [9] An agent for treating or preventing arrhythmia, the agent containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in [1], [2], [3] or [4]. [10] An agent for treating or preventing angina pectoris, reperfusion arrhythmia and myocardial infarction caused by ischemia, ischemic arrhythmia, organ disorders caused by ischemia and reperfusion, cerebral ischemic disorders, cerebral apoplexy and ischemic diseases of limbs and peripheral organs, the agent containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in [1], [2], [3] or [4]. [11] An agent for treating or preventing diseases caused by cell proliferation or hypertrophy, the agent containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in [1], [2], [3] or [4]. [12] An agent for treating or preventing organ disorders caused by ischemia in surgical operation or transplantation of internal organs, the agent containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in [1], [2], [3] or [4]. [13] An agent for treating or preventing diseases caused by infiltration of leukocytes, the agent containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in [1], [2], [3] or [4]. [14] A protective solution of internal organs cut from the body for transplantation or internal organs transplanted, the protective solution containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in [1], [2], [3] or [4]. [15] An agent for diagnosis of hypertension, diseases caused by cell growth and diabetes through inhibition of a Na + /H + exchanger, said agent containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in [1], [2], [3] or [4]. The present invention will be described in detail below. R 1 , R 2 , R 3 and R 4 in formula (1) are explained hereinafter. The alkyl group having from 1 to 6 carbon atoms, as represented by R 1 , R 2 , R 3 and R 4 , is a linear, branched or cyclic alkyl group having from 1 to 6 carbon atoms. Examples of the alkyl group include methyl, ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl, isopropyl, 2-methylpropyl, 1-methylpropyl, tert-butyl, 2-methylbutyl, 1-methylbutyl, 1,2-dimethylpropyl, 1,1-dimethylpropyl, 2,2-dimethylpropyl, 4-methylpentyl, 3-methylpentyl, 2-methylpentyl, 1-methylpentyl, 1,2,2-trimethylpropyl, 1,1-dimethylbutyl, 1,1,2-trimethylpropyl, 2,2-dimethylbutyl, 1,3-dimethylbutyl, 2,3-dimethylbutyl, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl groups. Examples of the halogen atom include iodine, bromine, chlorine and fluorine atoms. The alkyloxy group having from 1 to 6 carbon atoms is a linear, branched or cyclic alkyloxy group having from 1 to 6 carbon atoms. Examples of the alkyloxy group include methoxy, ethoxy, n-propyloxy, n-butyloxy, n-pentyloxy, n-hexyloxy, isopropyloxy, 2-methylpropyloxy, 1-methylpropyloxy, tert-butyloxy, 2-methylbutyloxy, 1-methylbutyloxy, 1,2-dimethylpropyloxy, 1,1-dimethylpropyloxy, 2,2-dimethylpropyloxy, 4-methylpentyloxy, 3-methylpentyloxy, 2-methylpentyloxy, 1-methylpentyloxy, 1,2,2-trimethylpropyloxy, 1,1-dimethylbutyloxy, 1,1,2-trimethylpropyloxy, 2,2-dimethylbutyloxy, 1,3-dimethylbutyloxy, 2,3-dimethylbutyloxy, cyclopropyloxy, cyclobutyloxy, cyclopentyloxy and cyclohexyloxy groups. The alkyloxy group having from 1 to 6 carbon atoms and containing a terminal alkyloxy group having from 1 to 6 carbon atoms include methoxymethyloxy, ethoxymethyloxy, n-propyloxyethyloxy, isopropyloxypropyloxy, cyclopropyloxybutyloxy, n-butyloxypentyloxy, tert-butyloxyhexyloxy, 2-methylpropyloxymethyloxy, 1-methyloxyethyloxy, n-pentyloxypropyloxy, cyclopentyloxymethyloxy, n-hexyloxybutyloxy and cyclohexyloxypentyloxy groups. Examples of the alkylsulfonylamino group having from 1 to 6 carbon atoms include methanesulfonylamino, ethanesulfonylamino, n-propanesulfonylamino, n-butanesulfonylamino, n-pentanesulfonylamino, n-hexanesulfonylamino, isopropanesulfonylamino, 2-methylpropanesulfonylamino, 1-methylpropanesulfonylamino, tert-butanesulfonylamino, 3-methylbutanesulfonylamino, 2-methylbutanesulfonylamino, 1-methylbutanesulfonylamino, 1,2-dimethylpropanesulfonylamino, 1,1-dimethylpropanesulfonylamino, 2,2-dimethylpropanesulfonylamino, 4-methylpentanesulfonylamino, 3-methylpentanesulfonylamino, 2-methylpentanesulfonylamino, 1-methylpentanesulfonylamino, 1,2,2-trimethylpropanesulfonylamino, 1,1-dimethylbutanesulfonylamino, 1,1,2-trimethylpropanesulfonylamino, 2,2-dimethylbutanesulfonylamino, 1,3-dimethylbutanesulfonylamino, 2,3-dimethylbutanesulfonylamino, cyclopropanesulfonylamino, cyclobutanesulfonylamino, cyclopentanesulfonylamino and cyclohexanesulfonylamino groups. Examples of the alkanoylamino group having from 2 to 6 carbon atoms include acetylamino, propionylamino, butyrylamino, valerylamino, hexanoylamino, isobutylylamino, isovalerylamino, pivaloylamino and cyclopentylcarbonylamino groups. One or two of R 1 , R 2 , R 3 and R 4 are preferably an alkyloxy group having from 1 to 6 carbon atoms. X 1 , X 2 , X 3 , X 4 and X 5 in formula (1) are explained hereinafter. The alkyl group having from 1 to 6 carbon atoms, as represented by X 1 , X 2 , X 3 , X 4 and X 5 , is a linear, branched or cyclic alkyl group having from 1 to 6 carbon atoms. Examples of the alkyl group include methyl, ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl, isopropyl, 2-methylpropyl, 1-methylpropyl, tert-butyl, 2-methylbutyl, 1-methylbutyl, 1,2-dimethylpropyl, 1,1-dimethylpropyl, 2,2-dimethylpropyl, 4-methylpentyl, 3-methylpentyl, 2-methylpentyl, 1-methylpentyl, 1,2,2-trimethylpropyl, 1,1-dimethylbutyl, 1,1,2-trimethylpropyl, 2,2-dimethylbutyl, 1,3-dimethylbutyl, 2,3-dimethylbutyl, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl groups. Examples of the halogen atom include iodine, bromine, chlorine and fluorine atoms. The alkyloxy group having from 1 to 6 carbon atoms is a linear, branched or cyclic alkyloxy group having from 1 to 6 carbon atoms. Examples of the alkyloxy group include methoxy, ethoxy, n-propyloxy, n-butyloxy, n-pentyloxy, n-hexyloxy, isopropyloxy, 2-methylpropyloxy, 1-methylpropyloxy, tert-butyloxy, 2-methylbutyloxy, 1-methylbutyloxy, 1,2-dimethylpropyloxy, 1,1-dimethylpropyloxy, 2,2-dimethylpropyloxy, 4-methylpentyloxy, 3-methylpentyloxy, 2-methylpentyloxy, 1-methylpentyloxy, 1,2,2-trimethylpropyloxy, 1,1-dimethylbutyloxy, 1,1,2-trimethylpropyloxy, 2,2-dimethylbutyloxy, 1,3-dimethylbutyloxy, 2,3-dimethylbutyloxy, cyclopropyloxy, cyclobutyloxy, cyclopentyloxy and cyclohexyloxy groups. The alkyloxy group having from 1 to 6 carbon atoms and containing a terminal alkyloxy group having from 1 to 6 carbon atoms include methoxymethyloxy, ethoxymethyloxy, n-propyloxyethyloxy, isopropyloxypropyloxy, cyclopropyloxybutyloxy, n-butyloxypentyloxy, tert-butyloxyhexyloxy, 2-methylpropyloxymethyloxy, 1-methyloxyethyloxy, n-pentyloxypropyloxy, cyclopentyloxymethyloxy, n-hexyloxybutyloxy and cyclohexyloxypentyloxy groups. X 1 is preferably a methyl group. In formula (1), the alkyl group having from 1 to 6 carbon atoms is a linear, branched or cyclic alkyl group having from 1 to 6 carbon atoms. Examples of the alkyl group include methyl, ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl, isopropyl, 2-methylpropyl, 1-methylpropyl, tert-butyl, 2-methylbutyl, 1-methylbutyl, 1,2-dimethylpropyl, 1,1-dimethylpropyl, 2,2-dimethylpropyl, 4-methylpentyl, 3-methylpentyl, 2-methylpentyl, 1-methylpentyl, 1,2,2-trimethylpropyl, 1,1-dimethylbutyl, 1,1,2-trimethylpropyl, 2,2-dimethylbutyl, 1,3-dimethylbutyl, 2,3-dimethylbutyl, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl groups. When R 1 , R 2 , R 3 , R 4 , X 1 , X 2 , X 3 , X 4 , X 5 or Y contains an asymmetric carbon atom in formula (1), the compounds of formula (1) in the present invention include optically active compounds. The compounds of formula (1) can be formed into pharmaceutically acceptable salts as required. Examples of the salts include salts with inorganic acids such as hydrochloric acid, hydrobromic acid, phosphoric acid and sulfuric acid or organic acids such as formic acid, acetic acid, fumaric acid, citric acid, maleic acid, oxalic acid, malic acid, tartaric acid, methanesulfonic acid, benzenesulfonic acid and p-toluenesulfonic acid. A process for producing the compounds of the present invention will be described in detail below. The compounds of the present invention can be produced by mixing quinoline-4-carboxylic acid derivatives represented by formula (2) wherein L represents a hydroxyl group or a leaving group that can easily be substituted by means of a nucleophilic reagent, and R 1 , R 2 , R 3 , R 4 , X 1 , X 2 , X 3 , X 4 , X 5 and Y are as defined in formula (1) with guanidine in the absence of a solvent or dissolving or suspending the same in an appropriate solvent or dispersing agent, and reacting the mixture. The ratio of the compounds of formula (2) and guanidine is not particularly limited. The molar ratio of the former:the latter is usually between 1:1 and 1:20, preferably between 1:3 and 1:10. The compounds obtained by this reaction can be purified by an ordinary method such as recrystallization or silica-gel column chromatography. The reaction will be explained when L is a hydroxyl group and when L is a group other than a hydroxyl group. (1) L is a hydroxyl group: A condensation agent can be used in the reaction. Appropriate examples of the solvent or the dispersing agent used in this reaction include benzene, toluene, xylene, 1,4-dioxane, dimethylformamide (hereinafter referred to as "DMF"), tetrahydrofuran (hereinafter referred to as "THF"), ethyl ether, 1,2-dimethoxyethane, dimethylsulfoxide (hereinafter referred to as "DMSO"), chloroform, dichloromethane, and 1,2-dichloroethane. Examples of the condensation agent which can be used in the reaction include 1,1'-carbonyldiimidazole [H. A. Staab, Angew. Chem. Int. Ed. Engl., 1 , 351 - 367, (1962)], dicyclohexylcarbodiimide (hereinafter referred to as "DCC"), 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide, and diphenylphosphorylazide. The reaction is conducted at a temperature ranging from -20°C to a reflux temperature of the reaction mixture, for example, from -10 to 150°C, preferably from room temperature to 100°C. The reaction time varies with conditions, and it is between approximately 1 and 48 hours. (2) L is a group other than a hydroxyl group: The active compounds of the quinoline-4-carboxylic acid derivatives represented by formula (2) include acid halides (L=halogen), acid anhydrides (especially mixed acid anhydrides-L=alkoxycarbonyloxy), and carboxylate esters. These can easily be formed from carboxylic acids (L=OH) of formula (2) by a known method. As an acid halide, a carbonyl chloride can be formed from a carboxylic acid using a chlorination agent such as thionyl chloride, oxalyl chloride or phosphorus pentachloride. An acid anhydride can be formed from a carboxylic acid using monoalkyl carbonate such as ethyl chlorocarbonate and base such as triethylamine. As a carboxylate ester, a methyl ester can be formed by, for example, treating a carboxylic acid with a hydrogen chloride gas in methanol, and p-nitrophenyl ester which is an active ester can be formed by treating p-nitrophenol with DCC. Appropriate examples of the solvent or the dispersing agent which is used in the reaction of the carboxylic acid active compounds and guanidine include methyl ethyl ketone, 1,4-dioxane, DMF, THF, ethyl ether, 1,2-dimethoxyethane, dimethyl sulfoxide, benzene, xylene, toluene, chloroform, dichloromethane, 1,2-dichloroethane, and pyridine. Alcohols such as methanol, ethanol and isopropanol can be used as required. The reaction of the quinoline-4-carboxylic acid active compounds and guanidine is conducted at a temperature ranging from -20°C to a reflux temperature of the reaction mixture, for example, from -10 to 150°C, preferably from 0 to 100°C. The reaction time varies with conditions. It is between approximately 1 and 48 hours. Examples of the base that accelerates this reaction include organic bases such as pyridine, dimethylaminopyridine, triethylamine, and diisopropylethylamine; and inorganic bases such as potassium carbonate, sodium carbonate, sodium hydroxide, and potassium hydroxide. When the quinoline-4-carboxylic acid (L=OH) of formula (2) contains an active group such as a hydroxyl group or an amino group, the active group is protected in advance with a protective group, and deprotection is conducted after the production of quinoline-4-carbonylguanidine by the above-mentioned process, whereby the final quinoline-4-carbonylguanidine derivatives of formula (1) can be obtained. At this time, the protection and the deprotection can be conducted by a known method [for example, T. W. Green: Protective Groups in Organic Synthesis, John Wiley & Sons (1981)]. When the quinoline-4-carbonylguanidine derivatives of formula (1) contain an amino group, these compounds can be produced by reducing quinoline-4-carbonylguanidine derivatives containing a nitro group in a known manner. The reduction is conducted under acidic conditions using a metal such as iron, zinc or the like, or through catalytic hydrogenation in the presence of a catalyst such as palladium on activated carbon (hereinafter referred to as "Pd/C"). A method of producing quinoline-4-carboxylic acid (L=OH) of formula (2) is described in, for example, G. Jones, The Chemistry of Heterocyclic Compounds, vol. 32, Quinolines Part I, John Wiley & Sons. It can be produced by the method of Doebner [Ber., 20 , 277 (1887), etc.] or the method of Pfitzinger [J. Prakt. Chem., 33 , 100 (1866), etc.]. In the method of Doebner, the reaction of aniline derivatives, benzaldehyde derivatives and pyruvic acid is conducted. In the method Pfitzinger, acetophenone is reacted with isatin derivatives. A method of producing isatin derivatives is described in, for example, F. D. Popp, The Chemistry of Isatin, Adv. Heterocycl. Chem., 18 , 1 - 58 (1975). The compounds of formula (1) in the present invention is used in a pharmaceutical composition which is effective as an agent for treating or preventing hypertension and arrhythmia caused by activation of NHE, diseases following ischemia which is a primary or secondary cause, diseases caused by cell proliferation or hypertrophy, and diseases caused by infiltration of leukocytes. Acute or chronic diseases caused by ischemia against which the compounds of the present invention are effective are, for example, angina pectoris, myocardial infarction, ischemic arrhythmia, reperfusion arrhythmia, organ disorders following ischemia and reperfusion, cerebral ischemic disorders, cerebral apoplexy, and ischemic diseases of limbs and peripheral internal organs. The compounds of the present invention can be used as an agent for treating or preventing organ disorders caused by ischemia and reperfusion in surgical operation or transplantation of internal organs, or as an agent for preventing or treating disorders of internal organs cut from the body for transplantation or internal organs transplanted. Diseases caused by cell proliferation or hypertrophy against which the compounds of the present invention are effective are, for example, arteriosclerosis, vascular restenosis caused by proliferation of a vascular smooth muscle after percutaneous transluminal coronary angioplasty (PTCA), rheumatoid arthritis caused by growth of synovial cells, diabetic complication caused by vascularization, renal glomerulosclerosis caused by growth of mesangial cells, fibrosis of lung, liver, kidney and the like caused by growth of fibroblasts, cardiac hypertrophy, prostatic hypertrophy and cancers. Diseases caused by infiltration of leukocytes associated with enhanced NHE activity against which the compounds of the present invention are effective are inflammation and the like. As mentioned above, it is known that NHE activity is enhanced in various diseased states. The NHE activity can easily be measured by using the compounds of the present invention being strong NHE inhibitors in cells such as platelets, erythrocytes and leukocytes which are easily obtainable. That is, the compounds of the present invention can be used as a diagnostic agent for hypertension, diseases caused by cell growth or diabetes. Specific examples of the compounds represented by formula (1) in the present invention are shown below. However, the present invention is not limited thereto. 1. 2-phenylquinoline-4-carbonylguanidine 2. 2-(2'-methylphenyl)quinoline-4-carbonylguanidine 3. 2-(2'-ethylphenyl)quinoline-4-carbonylguanidine 4. 2-(2'-n-propylphenyl)quinoline-4-carbonylguanidine 5. 2-(2'-isopropylphenyl)quinoline-4-carbonylguanidine 6. 2-(2'-n-butylphenyl)quinoline-4-carbonylguanidine 7. 2-(2'-cyclobutylphenyl)quinoline-4-carbonylguanidine 8. 2-{2'-(2-methylpropyl)phenyl}quinoline-4-carbonylguanidine 9. 2-{2'-(1-methylpropyl)phenyl}quinoline-4-carbonylguanidine 10. 2-{2'-(1,1-dimethylpropyl)phenyl}quinoline-4-carbonylguanidine 11. 2-{2'-(1,2-dimethylpropyl)phenyl}quinoline-4-carbonylguanidine 12. 2-{2'-(2,2-dimethylpropyl)phenyl}quinoline-4-carbonylguanidine 13. 2-(2'-n-pentylphenyl)quinoline-4-carbonylguanidine 14. 2-(2'-cyclopentylphenyl)quinoline-4-carbonylguanidine 15. 2-{2'-(1-methylbutyl)phenyl}quinoline-4-carbonylguanidine 16. 2-(2'-n-hexylphenyl)quinoline-4-carbonylguanidine 17. 2-{2'-(3-methylpentyl)}phenylquinoline-4-carbonylguanidine 18. 2-{2'-(1,3-dimethylbutyl)phenyl}quinoline-4-carbonylguanidine 19. 2-(3'-methylphenyl)quinoline-4-carbonylguanidine 20. 2-(3'-cyclopropylphenyl)quinoline-4-carbonylguanidine 21. 2-(3'-isopropylphenyl)quinoline-4-carbonylguanidine 22. 2-{3'-(3-methylbutyl)phenyl}quinoline-4-carbonylguanidine 23. 2-(3'-cyclohexylphenyl)quinoline-4-carbonylguanidine 24. 2-{3'-(2-methylpentyl)phenyl}quinoline-4-carbonylguanidine 25. 2-{3'-(1,2,2-trimethylpropyl)phenyl}quinoline-4-carbonylguanidine 26. 2-{3'-(1,1,2-trimethylpropyl)phenyl}quinoline-4-carbonylguanidine 27. 2-{3'-(1,1-dimethylbutyl)phenyl}quinoline-4-carbonylguanidine 28. 2-(4'-methylphenyl)quinoline-4-carbonylguanidine 29. 2-(4'-tert-butylphenyl)quinoline-4-carbonylguanidine 30. 2-{4'-(2-methylbutyl)phenyl}quinoline-4-carbonylguanidine 31. 2-{4'-(2,2-dimethylbutyl)phenyl}quinoline-4-carbonylguanidine 32. 2-{4'-(2,3-dimethylbutyl)phenyl}quinoline-4-carbonylguanidine 33. 2-{4'-(4-methylpentyl)phenyl}quinoline-4-carbonylguanidine 34. 2-{4'-(1-methylpentyl)phenyl}quinoline-4-carbonylguanidine 35. 2-(2',3'-dimethylphenyl)quinoline-4-carbonylguanidine 36. 2-(2',4'-dimethylphenyl)quinoline-4-carbonylguanidine 37. 2-(2',5'-dimethylphenyl)quinoline-4-carbonylguanidine 38. 2-(2',6'-dimethylphenyl)quinoline-4-carbonylguanidine 39. 2-(3',4'-dimethylphenyl)quinoline-4-carbonylguanidine 40. 2-(3',5'-dimethylphenyl)quinoline-4-carbonylguanidine 41. 2-(2',4',6'-trimethylphenyl)quinoline-4-carbonylguanidine 42. 2-(2'-chlorophenyl)quinoline-4-carbonylguanidine 43. 2-(3'-chlorophenyl)quinoline-4-carbonylguanidine 44. 2-(4'-bromophenyl)quinoline-4-carbonylguanidine 45. 2-(4'-iodophenyl)quinoline-4-carbonylguanidine 46. 2-(3'-fluorophenyl)quinoline-4-carbonylguanidine 47. 2-(4'-fluorophenyl)quinoline-4-carbonylguanidine 48. 2-(2'-nitrophenyl)quinoline-4-carbonylguanidine 49. 2-(3'-nitrophenyl)quinoline-4-carbonylguanidine 50. 2-(4'-nitrophenyl)quinoline-4-carbonylguanidine 51. 2-(2'-aminophenyl)quinoline-4-carbonylguanidine 52. 2-(3'-aminophenyl)quinoline-4-carbonylguanidine 53. 2-(4'-aminophenyl)quinoline-4-carbonylguanidine 54. 2-(2'-hydroxyphenyl)quinoline-4-carbonylguanidine 55. 2-(3'-hydroxyphenyl)quinoline-4-carbonylguanidine 56. 2-(4'-hydroxyphenyl)quinoline-4-carbonylguanidine 57. 2-(2'-trifluoromethylphenyl)quinoline-4-carbonylguanidine 58. 2-(3'-trifluoromethylphenyl)quinoline-4-carbonylguanidine 59. 2-(4'-trifluoromethylphenyl)quinoline-4-carbonylguanidine 60. 2-(2'-trifluoromethoxyphenyl)quinoline-4-carbonylguanidine 61. 2-(3'-trifluoromethoxyphenyl)quinoline-4-carbonylguanidine 62. 2-(4'-trifluoromethoxyphenyl)quinoline-4-carbonylguanidine 63. 2-(2'-methoxyphenyl)quinoline-4-carbonylguanidine 64. 2-(3'-methoxyphenyl)quinoline-4-carbonylguanidine 65. 2-(4'-methoxyphenyl)quinoline-4-carbonylguanidine 66. 2-(2'-ethoxyphenyl)quinoline-4-carbonylguanidine 67. 2-(2'-n-propyloxyphenyl)quinoline-4-carbonylguanidine 68. 2-(2'-isopropyloxyphenyl)quinoline-4-carbonylguanidine 69. 2-(2'-n-butyloxyphenyl)quinoline-4-carbonylguanidine 70. 2-(2'-cyclobutyloxyphenyl)quinoline-4-carbonylguanidine 71. 2-{2'-(2-methylpropyloxy)phenyl}quinoline-4-carbonylguanidine 72. 2-{2'-(1-methylpropyloxy)phenyl}quinoline-4-carbonylguanidine 73. 2-{2'-(1,1-dimethylpropyloxy)phenyl}quinoline-4-carbonylguanidine 74. 2-{2'-(1,2-dimethylpropyloxy)phenyl}quinoline-4-carbonylguanidine 75. 2-{2'-(2,2-dimethylpropyloxy)phenyl}quinoline-4-carbonylguanidine 76. 2-(2'-n-pentyloxyphenyl)quinoline-4-carbonylguanidine 77. 2-(2'-cyclopentyloxyphenyl)quinoline-4-carbonylguanidine 78. 2-{2'-(1-methylbutyloxy)phenyl}quinoline-4-carbonylguanidine 79. 2-(2'-n-hexyloxyphenyl)quinoline-4-carbonylguanidine 80. 2-{2'-(3-methylpentyloxy)phenyl}quinoline-4-carbonylguanidine 81. 2-{2'-(1,3-dimethylbutyloxy)phenyl}quinoline-4-carbonylguanidine 82. 2-(3'-cyclopropyloxyphenyl)quinoline-4-carbonylguanidine 83. 2-(3'-isopropyloxyphenyl)quinoline-4-carbonylguanidine 84. 2-(3'-tert-butyloxyphenyl)quinoline-4-carbonylguanidine 85. 2-{3'-(3-methylbutyloxy)phenyl}quinoline-4-carbonylguanidine 86. 2-(3'-cyclohexyloxyphenyl)quinoline-4-carbonylguanidine 87. 2-{3'-(2-methylpentyloxy)phenyl}quinoline-4-carbonylguanidine 88. 2-{3'-(1,2,2-trimethylpropyloxy)phenyl}quinoline-4-carbonylguanidine 89. 2-{3'-(1,1,2-trimethylpropyloxy)phenyl}quinoline-4-carbonylguanidine 90. 2-{3'-(1,1-dimethylbutyloxy)phenyl}quinoline-4-carbonylguanidine 91. 2-{4'-(2-methylbutyloxy)phenyl}quinoline-4-carbonylguanidine 92. 2-{4'-(2,2-dimethylbutyloxy)phenyl}quinoline-4-carbonylguanidine 93. 2-{4'-(2,3-dimethylbutyloxy)phenyl}quinoline-4-carbonylguanidine 94. 2-{4'-(4-methylpentyloxy)phenyl}quinoline-4-carbonylguanidine 95. 2-{4'-(1-methylpentyloxy)phenyl}quinoline-4-carbonylguanidine 96. 2-(2',3'-dimethoxyphenyl)quinoline-4-carbonylguanidine 97. 2-(2',4'-dimethoxyphenyl)quinoline-4-carbonylguanidine 98. 2-(2',5'-dimethoxyphenyl)quinoline-4-carbonylguanidine 99. 2-(2',6'-dimethoxyphenyl)quinoline-4-carbonylguanidine 100. 2-(3',4'-dimethoxyphenyl)quinoline-4-carbonylguanidine 101. 2-(3',5'-dimethoxyphenyl)quinoline-4-carbonylguanidine 102. 2-(2'-methoxymethyloxyphenyl)quinoline-4-carbonylguanidine 103. 2-(3'-ethoxymethyloxyphenyl)quinoline-4-carbonylguanidine 104. 2-(4'-n-propyloxyethyloxyphenyl)quinoline-4-carbonylguanidine 105. 2-(2'-isopropyloxypropyloxyphenyl)quinoline-4-carbonylguanidine 106. 2-(3'-cyclopropyloxybutyloxyphenyl)quinoline-4-carbonylguanidine 107. 2-(4'-n-butyloxypentyloxyphenyl)quinoline-4-carbonylguanidine 108. 2-(2'-tert-butyloxyhexyloxyphenyl)quinoline-4-carbonylguanidine 109. 2-{3'-(2-methylpropyloxymethyloxy)phenyl}quinoline-4-carbonylguanidine 110. 2-{4'-(1-methylpropyloxyethyloxy)phenyl}quinoline-4-carbonylguanidine 111. 2-(2'-n-pentyloxypropyloxyphenyl)quinoline-4-carbonylguanidine 112. 2-(3'-cyclopentyloxymethyloxyphenyl)quinoline-4-carbonylguanidine 113. 2-(4'-n-hexyloxypentyloxyphenyl)quinoline-4-carbonylguanidine 114. 2-phenyl-3-methylquinoline-4-carbonylguanidine 115. 2-(2'-methylphenyl)-3-methylquinoline-4-carbonylguanidine 116. 2-phenyl-3-ethylquinoline-4-carbonylguanidine 117. 2-(2'-methylphenyl)-3-ethylquinoline-4-carbonylguanidine 118. 2-phenyl-3-n-propylquinoline-4-carbonylguanidine 119. 2-(2'-methylphenyl)-3-n-propylquinoline-4-carbonylguanidine 120. 2-phenyl-3-isopropylquinoline-4-carbonylguanidine 121. 2-(2'-methylphenyl)-3-isopropylquinoline-4-carbonylguanidine 122. 2-phenyl-3-cyclopropylquinoline-4-carbonylguanidine 123. 2-phenyl-3-n-butylquinoline-4-carbonylguanidine 124. 2-phenyl-3-tert-butylquinoline-4-carbonylguanidine 125. 2-phenyl-3-(2-methylpropyl)quinoline-4-carbonylguanidine 126. 2-phenyl-3-(1-methylpropyl)quinoline-4-carbonylguanidine 127. 2-phenyl-3-cyclobutylquinoline-4-carbonylguanidine 128. 2-phenyl-3-n-pentylquinoline-4-carbonylguanidine 129. 2-phenyl-3-(2-methylbutyl)quinoline-4-carbonylguanidine 130. 2-phenyl-3-(1-methylbutyl)quinoline-4-carbonylguanidine 131. 2-phenyl-3-(1,2-dimethylpropyl)quinoline-4-carbonylguanidine 132. 2-phenyl-3-(1,1-dimethylpropyl)quinoline-4-carbonylguanidine 133. 2-phenyl-3-(2,2-dimethylpropyl)quinoline-4-carbonylguanidine 134. 2-phenyl-3-cyclopentylquinoline-4-carbonylguanidine 135. 2-phenyl-3-n-hexylquinoline-4-carbonylguanidine 136. 2-phenyl-3-(4-methylpentyl)quinoline-4-carbonylguanidine 137. 2-phenyl-3-(3-methylpentyl)quinoline-4-carbonylguanidine 138. 2-phenyl-3-(2-methylpentyl)quinoline-4-carbonylguanidine 139. 2-phenyl-3-(1-methylpentyl)quinoline-4-carbonylguanidine 140. 2-phenyl-3-(1,2,2-trimethylpropyl)quinoline-4-carbonylguanidine 141. 2-phenyl-3-(1,1-dimethylbutyl)quinoline-4-carbonylguanidine 142. 2-phenyl-3-(1,1,2-trimethylpropyl)quinoline-4-carbonylguanidine 143. 2-phenyl-3-(2,2-dimethylbutyl)quinoline-4-carbonylguanidine 144. 2-phenyl-3-(1,3-dimethylbutyl)quinoline-4-carbonylguanidine 145. 2-phenyl-3-(2,3-dimethylbutyl)quinoline-4-carbonylguanidine 146. 2-phenyl-3-cyclohexylquinoline-4-carbonylguanidine 147. 2-phenyl-5-methylquinoline-4-carbonylguanidine 148. 2-phenyl-6-methylquinoline-4-carbonylguanidine 149. 2-phenyl-7-methylquinoline-4-carbonylguanidine 150. 2-phenyl-8-methylquinoline-4-carbonylguanidine 151. 2-(2'-methylphenyl)-5-methylquinoline-4-carbonylguanidine 152. 2-phenyl-6-ethylquinoline-4-carbonylguanidine 153. 2-phenyl-7-n-propylquinoline-4-carbonylguanidine 154. 2-phenyl-6-isopropylquinoline-4-carbonylguanidine 155. 2-phenyl-5-n-butylquinoline-4-carbonylguanidine 156. 2-phenyl-6-tert-butylquinoline-4-carbonylguanidine 157. 2-phenyl-7-(2-methylpropyl)quinoline-4-carbonylguanidine 158. 2-phenyl-8-(1-methylpropyl)quinoline-4-carbonylguanidine 159. 2-phenyl-5-cyclobutylquinoline-4-carbonylguanidine 160. 2-phenyl-6-n-pentylquinoline-4-carbonylguanidine 161. 2-phenyl-7-(2-methylbutyl)quinoline-4-carbonylguanidine 162. 2-phenyl-8-(1-methylbutyl)quinoline-4-carbonylguanidine 163. 2-phenyl-5-(1,2-dimethylpropyl)quinoline-4-carbonylguanidine 164. 2-phenyl-6-(1,1-dimethylpropyl)quinoline-4-carbonylguanidine 165. 2-phenyl-7-(2,2-dimethylpropyl)quinoline-4-carbonylguanidine 166. 2-phenyl-7-cyclopentylquinoline-4-carbonylguanidine 167. 2-phenyl-8-n-hexylquinoline-4-carbonylguanidine 168. 2-phenyl-5-(4-methylpentyl)quinoline-4-carbonylguanidine 169. 2-phenyl-6-(3-methylpentyl)quinoline-4-carbonylguanidine 170. 2-phenyl-7-(2-methylpentyl)quinoline-4-carbonylguanidine 171. 2-phenyl-8-(1-methylpentyl)quinoline-4-carbonylguanidine 172. 2-phenyl-5-(1,2,2-trimethylpropyl)quinoline-4-carbonylguanidine 173. 2-phenyl-6-(1,1-dimethylbutyl)quinoline-4-carbonylguanidine 174. 2-phenyl-7-(1,1,2-trimethylpropyl)quinoline-4-carbonylguanidine 175. 2-phenyl-8-(2,2-dimethylbutyl)quinoline-4-carbonylguanidine 176. 2-phenyl-5-(1,3-dimethylbutyl)quinoline-4-carbonylguanidine 177. 2-phenyl-6-(2,3-dimethylbutyl)quinoline-4-carbonylguanidine 178. 2-phenyl-7-cyclohexylquinoline-4-carbonylguanidine 179. 2-phenyl-5-fluoroquinoline-4-carbonylguanidine 180. 2-phenyl-5-chloroquinoline-4-carbonylguanidine 181. 2-(2'-methylphenyl)-5-fluoroquinoline-4-carbonylguanidine 182. 2-(2'-methylphenyl)-5-chloroquinoline-4-carbonylguanidine 183. 2-(2'-methylphenyl)-5-bromoquinoline-4-carbonylguanidine 184. 2-(2'-methylphenyl)-5-iodoquinoline-4-carbonylguanidine 185. 2-phenyl-6-fluoroquinoline-4-carbonylguanidine 186. 2-phenyl-6-chloroquinoline-4-carbonylguanidine 187. 2-phenyl-6-iodoquinoline-4-carbonylguanidine 188. 2-phenyl-7-bromoquinoline-4-carbonylguanidine 189. 2-phenyl-7-chloroquinoline-4-carbonylguanidine 190. 2-phenyl-8-chloroquinoline-4-carbonylguanidine 191. 2-phenyl-8-iodoquinoline-4-carbonylguanidine 192. 2-phenyl-5-nitroquinoline-4-carbonylguanidine 193. 2-phenyl-6-nitroquinoline-4-carbonylguanidine 194. 2-phenyl-7-nitroquinoline-4-carbonylguanidine 195. 2-phenyl-8-nitroquinoline-4-carbonylguanidine 196. 2-phenyl-5-aminoquinoline-4-carbonylguanidine 197. 2-phenyl-6-aminoquinoline-4-carbonylguanidine 198. 2-phenyl-7-aminoquinoline-4-carbonylguanidine 199. 2-phenyl-8-aminoquinoline-4-carbonylguanidine 200. 2-phenyl-5-hydroxyquinoline-4-carbonylguanidine 201. 2-phenyl-6-hydroxyquinoline-4-carbonylguanidine 202. 2-phenyl-7-hydroxyquinoline-4-carbonylguanidine 203. 2-phenyl-8-hydroxyquinoline-4-carbonylguanidine 204. 2-(2'-methylphenyl)-5-hydroxyquinoline-4-carbonylguanidine 205. 2-(2'-methylphenyl)-6-hydroxyquinoline-4-carbonylguanidine 206. 2-(2'-methylphenyl)-7-hydroxyquinoline-4-carbonylguanidine 207. 2-(2'-methylphenyl)-8-hydroxyquinoline-4-carbonylguanidine 208. 2-(2'-methylphenyl)-5,6-dihydroxyquinoline-4-carbonylguanidine 209. 2-(2'-methylphenyl)-5,7-dihydroxyquinoline-4-carbonylguanidine 210. 2-(2'-methylphenyl)-5,8-dihydroxyquinoline-4-carbonylguanidine 211. 2-(2'-methylphenyl)-6,7-dihydroxyquinoline-4-carbonylguanidine 212. 2-(2'-methylphenyl)-6,8-dihydroxyquinoline-4-carbonylguanidine 213. 2-(2'-methylphenyl)-7,8-dihydroxyquinoline-4-carbonylguanidine 214. 2-phenyl-5-methoxyquinoline-4-carbonylguanidine 215. 2-phenyl-6-methoxyquinoline-4-carbonylguanidine 216. 2-phenyl-7-methoxyquinoline-4-carbonylguanidine 217. 2-phenyl-8-methoxyquinoline-4-carbonylguanidine 218. 2-phenyl-5,6-dimethoxyquinoline-4-carbonylguanidine 219. 2-phenyl-5,7-dimethoxyquinoline-4-carbonylguanidine 220. 2-phenyl-5,8-dimethoxyquinoline-4-carbonylguanidine 221. 2-phenyl-6,7-dimethoxyquinoline-4-carbonylguanidine 222. 2-phenyl-6,8-dimethoxyquinoline-4-carbonylguanidine 223. 2-phenyl-7,8-dimethoxyquinoline-4-carbonylguanidine 224. 2-phenyl-5,6,7-trimethoxyquinoline-4-carbonylguanidine 225. 2-phenyl-5,6,8-trimethoxyquinoline-4-carbonylguanidine 226. 2-phenyl-5,7,8-trimethoxyquinoline-4-carbonylguanidine 227. 2-phenyl-6,7,8-trimethoxyquinoline-4-carbonylguanidine 228. 2-phenyl-5,6,7,8-tetramethoxyquinoline-4-carbonylguanidine 229. 2-(2'-methylphenyl)-5-methoxyquinoline-4-carbonylguanidine 230. 2-(2'-methylphenyl)-6-methoxyquinoline-4-carbonylguanidine 231. 2-(2'-methylphenyl)-7-methoxyquinoline-4-carbonylguanidine 232. 2-(2'-methylphenyl)-8-methoxyquinoline-4-carbonylguanidine 233. 2-(2'-methylphenyl)-5,6-dimethoxyquinoline-4-carbonylguanidine 234. 2-(2'-methylphenyl)-5,7-dimethoxyquinoline-4-carbonylguanidine 235. 2-(2'-methylphenyl)-5,8-dimethoxyquinoline-4-carbonylguanidine 236. 2-(2'-methylphenyl)-6,7-dimethoxyquinoline-4-carbonylguanidine 237. 2-(2'-methylphenyl)-6,8-dimethoxyquinoline-4-carbonylguanidine 238. 2-(2'-methylphenyl)-7,8-dimethoxyquinoline-4-carbonylguanidine 239. 2-(2'-methylphenyl)-5,6,7-trimethoxyquinoline-4-carbonylguanidine 240. 2-(2'-methylphenyl)-5,6,8-trimethoxyquinoline-4-carbonylguanidine 241. 2-(2'-methylphenyl)-5,7,8-trimethoxyquinoline-4-carbonylguanidine 242. 2-(2'-methylphenyl)-6,7,8-trimethoxyquinoline-4-carbonylguanidine 243. 2-(2'-methylphenyl)-5,6,7,8-tetramethoxyquinoline-4-carbonylguanidine 244. 2-phenyl-5-ethoxyquinoline-4-carbonylguanidine 245. 2-phenyl-6-ethoxyquinoline-4-carbonylguanidine 246. 2-phenyl-7-ethoxyquinoline-4-carbonylguanidine 247. 2-phenyl-8-ethoxyquinoline-4-carbonylguanidine 248. 2-(2'-methylphenyl)-5-ethoxyquinoline-4-carbonylguanidine 249. 2-(2'-methylphenyl)-6-ethoxyquinoline-4-carbonylguanidine 250. 2-(2'-methylphenyl)-7-ethoxyquinoline-4-carbonylguanidine 251. 2-(2'-methylphenyl)-8-ethoxyquinoline-4-carbonylguanidine 252. 2-(2'-methylphenyl)-5-n-propyloxyquinoline-4-carbonylguanidine 253. 2-(2'-methylphenyl)-6-isopropyloxyquinoline-4-carbonylguanidine 254. 2-(2'-methylphenyl)-7-cyclopropyloxyquinoline-4-carbonylguanidine 255. 2-(2'-methylphenyl)-8-n-butyloxyquinoline-4-carbonylguanidine 256. 2-(2'-methylphenyl)-5-tert-butyloxyquinoline-4-carbonylguanidine 257. 2-(2'-methylphenyl)-6-cyclobutyloxyquinoline-4-carbonylguanidine 258. 2-(2'-methylphenyl)-7-(2-methylpropyloxy)quinoline-4-carbonylguanidine 259. 2-(2'-methylphenyl)-8-(1-methylpropyloxy)quinoline-4-carbonylguanidine 260. 2-(2'-methylphenyl)-5-n-pentyloxyquinoline-4-carbonylguanidine 261. 2-(2'-methylphenyl)-6-cyclopentyloxyquinoline-4-carbonylguanidine 262. 2-(2'-methylphenyl)-7-(2-methylbutyloxy)quinoline-4-carbonylguanidine 263. 2-(2'-methylphenyl)-8-(1-methylbutyloxy)quinoline-4-carbonylguanidine 264. 2-(2'-methylphenyl)-5-(1,2-dimethylpropyloxy)quinoline-4-carbonylguanidine 265. 2-(2'-methylphenyl)-6-(1,1-dimethylpropyloxy)quinoline-4-carbonylguanidine 266. 2-(2'-methylphenyl)-7-(2,2-dimethylpropyloxy)quinoline-4-carbonylguanidine 267. 2-(2'-methylphenyl)-8-n-pentyloxyquinoline-4-carbonylguanidine 268. 2-(2'-methylphenyl)-5-cyclopentyloxyquinoline-4-carbonylguanidine 269. 2-(2'-methylphenyl)-6-(4-methylpentyloxy)quinoline-4-carbonylguanidine 270. 2-(2'-methylphenyl)-7-(3-methylpentyloxy)quinoline-4-carbonylguanidine 271. 2-(2'-methylphenyl)-8-(2-methylpentyloxy)quinoline-4-carbonylguanidine 272. 2-(2'-methylphenyl)-5-(1-methylpentyloxy)quinoline-4-carbonylguanidine 273. 2-(2'-methylphenyl)-6-(1,2,2-trimethylpropyloxy)quinoline-4-carbonylguanidine 274. 2-(2'-methylphenyl)-7-(1,1-dimethylbutyloxy)quinoline-4-carbonylguanidine 275. 2-(2'-methylphenyl)-8-(1,1,2-trimethylpropyloxy)quinoline-4-carbonylguanidine 276. 2-(2'-methylphenyl)-5-(2,2-dimethylbutyloxy)quinoline-4-carbonylguanidine 277. 2-(2'-methylphenyl)-6-(2,3-dimethylbutyloxy)quinoline-4-carbonylguanidine 278. 2-(2'-methylphenyl)-5-methoxymethyloxyquinoline-4-carbonylguanidine 279. 2-phenyl-8-methoxyethyloxyquinoline-4-carbonylguanidine 280. 2-(2'-methylphenyl)-6-ethoxymethyloxyquinoline-4-carbonylguanidine 281. 2-(2'-methylphenyl)-7-methoxymethyloxyquinoline-4-carbonylguanidine 282. 2-(2'-methylphenyl)-7-n-propyloxyethyloxyquinoline-4-carbonylguanidine 283. 2-(2'-methylphenyl)-8-isopropyloxypropyloxyquinoline-4-carbonylguanidine 284. 2-(2'-methylphenyl)-5-cyclopropyloxybutyloxyquinoline-4-carbonylguanidine 285. 2-(2'-methylphenyl)-6-n-butyloxypentyloxyquinoline-4-carbonylguanidine 286. 2-(2'-methylphenyl)-7-tert-butyloxyhexyloxyquinoline-4-carbonylguanidine 287. 2-(2'-methylphenyl)-8-(2-methylpropyloxymethyloxy)quinoline-4-carbonylguanidine 288. 2-(2'-methylphenyl)-5-(1-methylpropyloxyethyloxy)quinoline-4-carbonylguanidine 289. 2-(2'-methylphenyl)-6-n-pentyloxypropyloxyquinoline-4-carbonylguanidine 290. 2-(2'-methylphenyl)-7-cyclopentyloxymethyloxyquinoline-4-carbonylguanidine 291. 2-(2'-methylphenyl)-8-n-hexyloxypentyloxyquinoline-4-carbonylguanidine 292. 2-phenyl-5-methanesulfonylaminoquinoline-4-carbonylguanidine 293. 2-phenyl-6-methanesulfonylaminoquinoline-4-carbonylguanidine 294. 2-phenyl-7-methanesulfonylaminoquinoline-4-carbonylguanidine 295. 2-phenyl-8-methanesulfonylaminoquinoline-4-carbonylguanidine 296. 2-(2'-methylphenyl)-5-methanesulfonylaminoquinoline-4-carbonylguanidine 297. 2-(2'-methylphenyl)-6-methanesulfonylaminoquinoline-4-carbonylguanidine 298. 2-(2'-methylphenyl)-7-methanesulfonylaminoquinoline-4-carbonylguanidine 299. 2-(2'-methylphenyl)-8-methanesulfonylaminoquinoline-4-carbonylguanidine 300. 2-phenyl-5-ethanesulfonylaminoquinoline-4-carbonylguanidine 301. 2-phenyl-6-ethanesulfonylaminoquinoline-4-carbonylguanidine 302. 2-phenyl-7-n-propanesulfonylaminoquinoline-4-carbonylguanidine 303. 2-phenyl-8-isopropanesulfonylaminoquinoline-4-carbonylguanidine 304. 2-phenyl-5-n-butanesulfonylaminoquinoline-4-carbonylguanidine 305. 2-phenyl-6-tert-butanesulfonylaminoquinoline-4-carbonylguanidine 306. 2-phenyl-7-(2-methylpropanesulfonylamino)quinoline-4-carbonylguanidine 307. 2-phenyl-8-(1-methylpropanesulfonylamino)quinoline-4-carbonylguanidine 308. 2-phenyl-5-cyclobutanesulfonylaminoquinoline-4-carbonylguanidine 309. 2-phenyl-6-n-pentanesulfonylaminoquinoline-4-carbonylguanidine 310. 2-phenyl-7-cyclopentanesulfonylaminoquinoline-4-carbonylguanidine 311. 2-phenyl-8-n-hexanesulfonylaminoquinoline-4-carbonylguanidine 312. 2-phenyl-5-cyclohexanesulfonylaminoquinoline-4-carbonylguanidine 313. 2-phenyl-5-acetylaminoquinoline-4-carbonylguanidine 314. 2-phenyl-6-acetylaminoquinoline-4-carbonylguanidine 315. 2-phenyl-7-acetylaminoquinoline-4-carbonylguanidine 316. 2-phenyl-8-acetylaminoquinoline-4-carbonylguanidine 317. 2-(2'-methylphenyl)-5-acetylaminoquinoline-4-carbonylguanidine 318. 2-(2'-methylphenyl)-6-acetylaminoquinoline-4-carbonylguanidine 319. 2-(2'-methylphenyl)-7-acetylaminoquinoline-4-carbonylguanidine 320. 2-(2'-methylphenyl)-8-acetylaminoquinoline-4-carbonylguanidine 321. 2-phenyl-5-propionylaminoquinoline-4-carbonylguanidine 322. 2-phenyl-6-butyrylaminoquinoline-4-carbonylguanidine 323. 2-phenyl-7-valerylaminoquinoline-4-carbonylguanidine 324. 2-phenyl-8-hexanoylaminoquinoline-4-carbonylguanidine 325. 2-phenyl-5-isobutyrylaminoquinoline-4-carbonylguanidine 326. 2-phenyl-6-isovalerylaminoquinoline-4-carbonylguanidine 327. 2-phenyl-7-pivaloylaminoquinoline-4-carbonylguanidine 328. 2-phenyl-8-cyclopentylcarbonylaminoquinoline-4-carbonylguanidine 329. 2-(2'-methylphenyl)-5-methoxy-6-methylquinoline-4-carbonylguanidine 330. 2-(2'-methylphenyl)-5-methoxy-7-methylquinoline-4-carbonylguanidine 331. 2-(2'-methylphenyl)-5-methoxy-8-methylquinoline-4-carbonylguanidine 332. 2-(2'-methylphenyl)-5-methyl-8-methoxyquinoline-4-carbonylguanidine 333. 2-(2'-methylphenyl)-6-methyl-8-methoxyquinoline-4-carbonylguanidine 334. 2-(2'-methylphenyl)-7-methyl-8-methoxyquinoline-4-carbonylguanidine 335. 2-(2'-methylphenyl)-5-methoxy-6-fluoroquinoline-4-carbonylguanidine 336. 2-(2'-methylphenyl)-5-methoxy-7-chloroquinoline-4-carbonylguanidine 337. 2-(2'-methylphenyl)-5-methoxy-8-bromoquinoline-4-carbonylguanidine 338. 2-(2'-methylphenyl)-5-methoxy-8-iodoquinoline-4-carbonylguanidine 339. 2-(2'-methylphenyl)-5-fluoro-8-methoxyquinoline-4-carbonylguanidine 340. 2-(2'-methylphenyl)-5-chloro-8-methoxyquinoline-4-carbonylguanidine 341. 2-(2'-methylphenyl)-5-iodo-8-methoxyquinoline-4-carbonylguanidine 342. 2-(2'-methylphenyl)-5-bromo-8-methoxyquinoline-4-carbonylguanidine 343. 2-phenyl-6-chloro-8-methylquinoline-4-carbonylguanidine 344. 2-phenyl-5-methoxy-8-methanesulfonylaminoquinoline-4-carbonylguanidine 345. 2-phenyl-5-methanesulfonylamino-8-methoxyquinoline-4-carbonylguanidine 346. 2-(2'-methylphenyl)-5-methoxy-8-methanesulfonylaminoquinoline-4-carbonylguanidine 347. 2-(2'-methylphenyl)-5-methanesulfonylamino-8-methoxyquinoline-4-carbonylguanidine 348. 2-phenyl-3-methyl-5,7-dimethoxyquinoline-4-carbonylguanidine 349. 2-phenyl-3-methyl-5,8-dimethoxyquinoline-4-carbonylguanidine 350. 2-(2'-methylphenyl)-3-methyl-5,7-dimethoxyquinoline-4-carbonylguanidine 351. 2-(2'-methylphenyl)-3-methyl-5,8-dimethoxyquinoline-4-carbonylguanidine When the compounds of formula (1) and pharmaceutically acceptable salts thereof in the present invention are used as an agent for treating or preventing hypertension, arrhythmia, diseases owing to ischemia which is a primary or secondary cause and diseases caused by cell growth and organic hyperplasia or hypertrophy (all of these result from activation of NHE), the above-mentioned compounds and salts can be administered either orally or parenterally. The form thereof varies with the properties of the compounds of the present invention which are used as an active ingredient. The preparations of these compounds can be obtained by a known method. These preparations can take various forms depending on therapeutic purposes. Typical forms are solids, solutions and suppositories. More specifically, the solids are tablets, pills, powders, granules and capsules. The solutions are injections, suspensions, syrups and emulsions. Other preparations are e.g. suppositories. When tablets are prepared, it is possible to use various carriers which have been well known in this field so far. Examples of the carriers include excipients such as lactose, sucrose, sodium chloride, glucose, urea, starch, calcium carbonate, kaolin, crystalline cellulose, and silicic acid; binders such as water, ethanol, propanol, simple syrup, liquid glucose, starch solution, gelatin solution, shellac solution, methyl cellulose solution, hydroxypropyl cellulose solution, polyvinyl pyrrolidone solution, and carboxymethyl cellulose solution; disintegrants such as dry starch, sodium alginate, agar powder, sodium hydrogencarbonate, calcium carbonate, polyoxyethylenesorbitan fatty acid esters, sodium laurylsulfate, stearic acid glyceride, starch, and lactose; disintegration suppressants such as sucrose, stearic acid, cocoa butter, and hydrogenated oil; absorption accelerators such as quaternary ammonium base, and sodium laurylsulfate; wetting agents such as glycerin, and starch; adsorbents such as starch, lactose, kaolin, bentonite, colloidal silicic acid, crystalline cellulose, and light silicic anhydride; and lubricants such as talc, stearate salt, boric acid powder, and polyethylene glycol. Further, in the case of tablets, coated tablets can be formed as required. Examples of the coated tablets include sugar-coated tablets, gelatin-coated tablets, enteric coated tablets, and film-coated tablets. Two-layered tablets and multi-layered tablets are also available. In the case of pills, a carrier which is known in this field can be used. Examples of the carrier include excipients such as glucose, lactose, starch, cocoa butter, hydrogenated vegetable oil, kaolin, and talc; binders such as gum arabic, tragacanth powder, and gelatin; and disintegrants such as carmellose calcium, and agar. In the case of capsules, usually, the active ingredient compound is mixed with the above-mentioned carrier, and the mixture is filled in a hard gelatin capsule or a soft capsule. In the case of injections, a known diluent is used in forming a solution, an emulsion or a suspension. Examples of the diluent include water, ethanol, macrogol, propylene glycol, ethoxyisostearyl alcohol, polyoxyisostearyl alcohol, polyoxyethylenesorbitan fatty acid esters, cottonseed oil, corn oil, peanut oil and olive oil. Further, a suspension is prepared in the presence of an appropriate surfactant by adding water to the compound of the present invention, or an emulsion is formed using a surfactant such as polyoxyethylene-hardened castor oil (HCO-60), Polysorbate 80 or polyethylene glycol. Sodium chloride, glucose or glycerin may be contained in pharmaceutical preparations, or an ordinary dissolution aid, buffer or analgesic may be added thereto. In the case of suppositories, a known carrier can be used. Examples of the carrier include polyethylene glycol, cocoa butter, higher alcohol, higher alcohol esters, gelatin, and semi-synthetic glyceride. Besides, a colorant, a preservative, a flavor, a seasoning and a sweetener can be contained in pharmaceutical preparations. A method of administering the pharmaceutical preparations of the present invention is not particularly limited, and it depends on the age, sex and other conditions of patients, and stages of diseases. For example, tablets, pills, solutions, suspensions, emulsions, powders, granules, syrups and capsules are administered orally. Injections are administered intravenously either singly or in combination with an ordinary aid such as glucose, amino acids or the like. Further, injections are administered intramuscularly, subcutaneously or intraperitoneally as required. Suppositories are administered intrarectally. The dose of these pharmaceutical preparations in the present invention is approximately selected depending on usage, the age, sex and other conditions of patients, and stages of diseases. The dose of the active ingredient compound for adults is preferably between approximately 0.001 and 1,000 mg. The amount of the active ingredient compound in the preparation in administration unit form is preferably between approximately 0.001 and 1,000 mg. The present invention will be illustrated specifically by referring to the following Production Reference Examples, Examples, Preparation Examples and Test Examples. However, the present invention is not limited thereto. Examples Reference Example 1 Synthesis of 2-(4'-methylphenyl)quinoline-4-carboxylic acid Ten milliliters (2.2 N) of a sodium hydroxide aqueous solution was added dropwise to an ethanol (20 ml) suspension containing 1.47 g of isatin and 2.67 ml of 4-methylacetophenone at room temperature, and the reaction mixture was then heat-refluxed for 5.5 hours. The resulting reaction mixture was allowed to cool, and then acidified with 2 N sulfuric acid to obtain an orange-colored precipitate. This precipitate was collected by filtration, and dried to form 2.34 g of the above-mentioned compound. 1 H-NMR(DMSO-d 6 ), δ : 2.55(s, 3H), 7.32-7.40(m, 3H), 7.66-7.71(m, 1H), 7.86(d, 1H), 8.15(d, 1H), 8.21(d, 1H), 8.43(s, 1H), 8.64(d, 2H) Reference Example 2 Synthesis of 2-(3'-methylphenyl)quinoline-4-carboxylic acid The above-mentioned compound (0.62 g) was formed from 1.47 g of isatin and 2.68 g of 3-methylacetophenone in the same manner as in Reference Example 1. 1 H-NMR(DMSO-d 6 ), δ : 2.46(s, 3H), 7.34(d, 1H), 7.47(t, 1H), 7.70(t, 1H), 7.86(t, 1H), 8.13(m, 3H), 8.46(s, 1H), 8.66(d, 1H) Reference Example 3 Synthesis of 2-(2'-methylphenyl)quinoline-4-carboxylic acid The above-mentioned compound (0.89 g) was formed from 1.47 g of isatin and 2.68 g of 2-methylacetophenone in the same manner as in Reference Example 1. 1 H-NMR(DMSO-d 6 ), δ : 2.42(s, 3H), 7.39(m, 3H), 7.55(m, 1H), 7.74(t, 1H), 7.87(t, 1H), 8.05(s, 1H), 8.14(d, 1H), 8.74(d, 1H) Reference Example 4 Synthesis of 2-(2',4'-dimethylphenyl)quinoline-4-carboxylic acid The above-mentioned compound (1.00 g) was formed from 1.47 g of isatin and 2.96 g of 2,4-dimethylacetophenone in the same manner as in Reference Example 1. 1 H-NMR(DMSO-d 6 ), δ: 2.37(s, 3H), 2.40(s, 3H), 7.17 (d, 2H), 7.46 (d, 1H), 7.72 (t, 1H), 7.85 (t, 1H), 8.02 (s, 1H), 8.12 (d, 1H), 8.72 (d, 1H) Reference Example 5 Synthesis of 2-(3',4'-dimethylphenyl)quinoline-4-carboxylic acid The above-mentioned compound (4.35 g) was formed from 2.0 g of isatin and 4.0 g of 3,4-dimethylacetophenone in the same manner as in Reference Example 1. 1 H-NMR(DMSO-d 6 ), δ : 2.32(s, 3H), 2.37(s, 3H), 7.33(d, 1H), 7.64-7.68(m, 1H), 7. 70-7.86(m, 1H), 8.00-8.17 (m,3H), 8.43(s, 1H), 8.65 (d, 1H) Reference Example 6 Synthesis of 2-(2',4',6'-trimethylphenyl)quinoline-4-carboxylic acid The above-mentioned compound (0.16 g) was formed from 2.21 g of isatin and 4.87 g of 2,4,6-trimethylacetophenone in the same manner as in Reference Example 1. 1 H-NMR(DMSO-d 6 ), δ : 1.98 (s, 6H), 2.32 (s, 3H), 6.99 (s, 2H), 7.75(t, 1H), 7.78 (s, 1H), 7.86 (t, 1H), 8.11(d, 1H), 8.75(d, 1H) m.p. 240°C (decomp.) Reference Example 7 Synthesis of 2-(4'-tert-butylphenyl)quinoline-4-carboxylic acid The above-mentioned compound (0.70 g) was formed from 1.47 g of isatin and 3.60 g of 4-tert-butylacetophenone in the same manner as in Reference Example 1. 1 H-NMR(DMSO-d 6 ), δ : 1.37 (s, 9H), 7.55 (m, 3H), 7.76 (t, 1H), 8.12 (d, 2H), 8.27 (d, 1H), 8.46 (s, 1H), 8.82 (d, 1H) Reference Example 8 Synthesis of 2-3'-trifluoromethylphenyl)quinoline-4-carboxylic acid The above-mentioned compound (1.89 g) was formed from 1.47 g of isatin and 3.76 g of 3-trifluoromethylacetophenone in the same manner as in Reference Example 1. 1 H-NMR(DMSO-d 6 ), δ : 7.75-7.92 (m, 4H), 8.24 (d, 1H), 8.60 (s, 1H), 8.65 (m, 3H) Reference Example 9 Synthesis of 2-2'-trifluoromethylphenyl)quinoline-4-carboxylic acid The above-mentioned compound (2.85 g) was formed from 1.90 g of isatin and 5.0 g of 2-trifluoromethylacetophenone in the same manner as in Reference Example 1. 1 H-NMR(DMSO-d 6 ), δ : 7.76 (m, 2H), 7.78 (s, 1H), 7.79 (s, 1H), 7.90 (s, 2H), 8.03 (s, 1H), 8.14 (d, 1H), 8.78 (d, 1H) Reference Example 10 Synthesis of 2-(4'-bromophenyl)quinoline-4-carboxylic acid The above-mentioned compound (3.00 g) was formed from 1.47 g of isatin and 3.98 g of 4-bromoacetophenone in the same manner as in Reference Example 1. 1 H-NMR(DMSO-d 6 ), δ : 7.73-7.84 (m, 4H), 8.17 (d, 1H), 8.28 (d, 2H), 8.47 (s, 1H), 8. 65 (d, 1H) Reference Example 11 Synthesis of 2-(4'-fluorophenyl)quinoline-4-carboxylic acid The above-mentioned compound (2.21 g) was formed from 1.47 g of isatin and 2.76 g of 4-fluoroacetophenone in the same manner as in Reference Example 1. 1 H-NMR(DMSO-d 6 ), δ : 7.31-7.44 (m, 2H), 7.68-7.74 (m, 1H), 7.83-7.93 (m, 1H), 8.1 6 (d, 1H), 8.35-8.40 (m, 2H), 8.47 (s, 1H), 8.64 (d, 1H) Reference Example 12 Synthesis of 2-(2'-chlorophenyl)quinoline-4-carboxylic acid The above-mentioned compound (0.90 g) was formed from 1.47 g of isatin and 3.1 g of 2-chloroacetophenone in the same manner as in Reference Example 1. 1 H-NMR(DMSO-d 6 ), δ : 7.12 (t, 1H), 7.21 (d, 1H), 7.48 (t, 1H), 7.61 (t, 1H), 7.78 (m, 2H), 7.99 (d, 1H), 8.08 (s, 1H), 8.74 (d,1H) Reference Example 13 Synthesis of 2-(4'-methoxyphenyl)quinoline-4-carboxylic acid The above-mentioned compound (1.54 g) was formed from 1.47 g of isatin and 3.0 g of 4-methoxyacetophenone in the same manner as in Reference Example 1. 1 H-NMR (DMSO-d 6 ), δ : 3.86 (s, 3H), 7.13 (d, 2H), 7.62-7.68 (m, 1H), 7.79-7.85 (m, 1 H), 7.94 (d, 1H), 8.27 (d, 2H), 8.39 (s, 1H), 8.61 (d, 1H) Reference Example 14 Synthesis of 2-(2'-methoxyphenyl)quinoline-4-carboxylic acid The above-mentioned compound (0.91 g) was formed from 1.47 g of isatin and 3.0 g of 2-methoxyacetophenone in the same manner as in Reference Example 1. 1 H-NMR (DMSO-d 6 ), δ : 3.89 (s, 3H), 7.14 (t, 1H), 7.22 (d, 1H), 7.50 (t, 1H), 7.72 (t, 1H), 7.85 (m, 2H), 8.13 (d, 1H), 8.33 (s, 1H), 8.92 (d, 1H) Reference Example 15 Synthesis of 2-(2',6'-dimethoxyphenyl)quinoline-4-carboxylic acid The above-mentioned compound (0.59 g) was formed from 1.50 g of isatin and 3.68 g of 2,6-dimethoxyacetophenone in the same manner as in Reference Example 1. 1 H-NMR(DMSO-d 6 ), δ : 3.64 (s, 6H), 6.76 (s, 1H), 6.80 (s, 1H), 7.40 (t, 1H), 7.46 (s, 1H), 7.55 (t, 1H), 7.69 (t, 1H), 7.95 (d, 1H), 8.75 (d, 1H) Reference Example 16 Synthesis of 2-(4'-trifluoromethoxyphenyl)quinoline-4-carboxylic acid The above-mentioned compound (2.27 g) was formed from 1.47 g of isatin and 4.08 g of 4-trifluoromethoxyacetophenone in the same manner as in Reference Example 1. 1 H-NMR (DMSO-d 6 ), δ : 7.55 (d, 2H), 7.72 (t, 1H), 7.87 (t, 1H), 8.19 (d, 1H), 8.41 (d, 2H), 8.49 (s, 1H), 8.58 (d, 1H) Reference Example 17 Synthesis of 2-Phenyl-3-methylquinoline-4-carboxylic acid Ten milliliters (2 N) of a sodium hydroxide aqueous solution was added dropwise to an ethanol (20 ml) suspension containing 1.47 g of isatin and 2.68 g of propiophenone at room temperature, and the reaction mixture was then heat-refluxed for 26 hours. The resulting reaction mixture was allowed to cool, and then concentrated under reduced pressure. Ice water was added to the residue, and the mixture was extracted with ethyl ether. The aqueous layer was acidified with dilute hydrochloric acid. The precipitate was collected by filtration, and dried to form 1.47 g of the above-mentioned compound. 1 H-NMR (DMSO-d 6 ), δ : 2.39 (s, 3H), 7.53-7.70 (m, 6H), 7.71-7.83 (m, 2H), 8.05 (d, 1 H) Reference Example 18 Synthesis of 2-phenyl-6-fluoroquinoline-4-carboxylic acid The above-mentioned compound (1.58 g) was formed from 1.65 g of 5-fluoroisatin and 2.40 g of acetophenone in the same manner as in Reference Example 1. 1 H-NMR (DMSO-d 6 ), δ : 7.55 (m, 3H), 7.80 (m, 1H), 8.26 (m, 1H), 8.48 (m, 1H), 8.50 (m, 1H), 8.56 (s, 1H) Reference Example 19 Synthesis of 2-phenyl-6-iodoquinoline-4-carboxylic acid The above-mentioned compound (2.01 g) was formed from 2.73 g of 5-iodoisatin and 2.40 g of acetophenone in the same manner as in Reference Example 1. 1 H-NMR (DMSO-d 6 ), δ : 7.57 (m, 3H), 7.92 (d, 1H), 8.12 (m, 1H), 8.28 (m, 2H), 8.51 (s, 1H), 9.15 (s, 1H) Reference Example 20 Synthesis of 2-phenyl-5-chloroquinoline-4-carboxylic acid The above-mentioned compound (0.42 g) was formed from 0.70 g of 4-chloroisatin prepared by a known method [A. E. Senear, J. Am. Chem. Soc., 68 , 2695 - 2697 (1946)] and 0.82 ml of acetophenone in the same manner as in Reference Example 1. 1 H-NMR (DMSO-d 6 ), δ : 7.52-7.62 (m, 3H), 7.81-7.86 (m, 2H), 8.16 (dd, 1H), 8.26 (s, 1H), 8.33-8.37 (m, 2H) Reference Example 21 Synthesis of 2-phenyl-6-chloroquinoline-4-carboxylic acid The above-mentioned compound (1.72 g) was formed from 1.47 g of 5-chloroisatin and 3.10 g of acetophenone in the same manner as in Reference Example 1. 1 H-NMR(DMSO-d 6 ), δ : 7.61 (s, 1H), 7.64 (s, 1H), 7.71 (t, 1H), 7.86 (t, 1H), 8.16 (t, 1H), 8.35 (s, 1H), 8.36 (s, 1H), 8.47 (s, 1H), 8.67 (d, 1H) Reference Example 22 Synthesis of 2-phenyl-7-chloroquinoline-4-carboxylic acid The above-mentioned compound (1.26 g) was formed from 1.0 g of 6-chloroisatin prepared by a known method (A. E. Senear, J. Am. Chem. Soc., 68 , 2695 - 2697 (1946)] and 1.3 ml of acetophenone in the same manner as in Reference Example 1. 1 H-NMR (DMSO-d 6 ), δ : 7.53-7.64 (m, 3H), 7.74 (dd, 1H), 8.21-8.30 (m, 3H), 8.49 (s, 1H), 8.73 (d, 1H) Reference Example 23 Synthesis of 2-phenyl-6-chloro-8-methylquinoline-4-carboxylic acid The above-mentioned compound (1.03 g) was formed from 1.95 g of 5-chloro-7-methylisatin and 2.40 g of acetophenone in the same manner as in Reference Example 1. 1 H-NMR(DMSO-d 6 ), δ : 2.53 (s, 3H), 7.55 (m, 3H), 7.65 (d, 1H), 8.03 (d, 1H), 8.25 (d, 2H), 8.35 (s, 1H), 8.46 (s, 1H) Reference Example 24 Synthesis of 2-phenyl-6-methylquinoline-4-carboxylic acid Benzaldehyde (2.12 g) and 2.14 g of p-toluidine were dissolved in 50 ml of ethanol, and 1.76 g of pyruvic acid were added thereto dropwise. The reaction mixture was then heat-refluxed for 6 hours. The resulting reaction mixture was cooled to room temperature, and then concentrated under reduced pressure. The residue was dissolved in a 1 N sodium hydroxide aqueous solution. This aqueous solution was extracted with ethyl ether, and the aqueous layer was acidified with dilute hydrochloric acid. The precipitate was collected by filtration, and dried to form 0.51 g of the above-mentioned compound. 1 H-NMR(DMSO-d 6 ), δ : 2.54 (s, 3H), 7.54 (m, 3H), 7.69 (d, 1H), 8.05 (d, 1H), 8.26 (d, 2H), 8.37(s, 1H), 8.44 (s, 1H) Reference Example 25 Synthesis of 2-(3'-nitrophenyl)quinoline-4-carboxylic acid The above-mentioned compound (0.75 g) was formed from 6.86 g of 3-nitrobenzaldehyde, 4.9 g of aniline and 2.0 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 7.25-7.36 (m, 1H), 7.85-7.91 (m, 2H), 8.20-8.31 (m, 1H), 8.3 7-8.40 (m, 1H), 8.60 (s, 1H), 8.69 (d, 1H), 8.76(d, 1H), 9.10-9.12 (m, 1H) Reference Example 26 Synthesis of 2-(2'-isopropylphenyl)quinoline-4-carboxylic acid The above-mentioned compound (1.48 g) was formed from 1.4 g of 2-isopropylbenzaldehyde prepared by a known method [Chem. Pharm. Bull., 35 , 1953 - 1968 (1987)], 0.88 g of aniline and 0.83 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 1.18 (d, 6H), 3.16-3.21 (m, 1H), 7.32-7.53 (m, 4H), 7.71 (t, 1 H), 7.84 (t, 1H), 7.92 (s, 1H), 8.10 (d, 1H), 8.73 (d, 1H) Reference Example 27 Synthesis of 2-phenyl-7-methylquinoline-4-carboxylic acid The above-mentioned compound (1.30 g) was formed from 4.0 g of benzaldehyde, 4.0 g of m-toluidine and 3.28 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 2.56 (s, 3H), 7.52-7.61 (m, 4H), 7.97 (s, 1H), 8.25 (d, 1H), 8. 36 (s, 1H), 8.56 (d, 1H) m.p. 233 - 237°C Reference Example 28 Synthesis of 2-phenyl-8-methylquinoline-4-carboxylic acid The above-mentioned compound (1.74 g) was formed from 3.96 g of benzaldehyde, 4.0 g of o-toluidine and 3.28 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 2.85 (s, 3H), 7.50-7.62 (m, 4H), 7.71 (d, 1H), 8.33-8.36 (m, 2 H), 8.47 (d, 2H) Reference Example 29 Synthesis of 2-phenyl-6-isopropylquinoline-4-carboxylic acid The above-mentioned compound (1.23 g) was formed from 1.59 g of benzaldehyde, 1.35 g of 4-isopropylaniline and 1.32 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 1.26 (d, 6H), 2.96-3.03 (m, 1H), 7.36-7.65 (m, 4H), 8.10-8.1 8 (m, 3H), 8.44 (s, 1H), 8.64 (s, 1H) Reference Example 30 Synthesis of 2-phenyl-8-chloroquinoline-4-carboxylic acid The above-mentioned compound (0.48 g) was formed from 2.12 g of benzaldehyde, 2.60 g of 2-chloroaniline and 1.80 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR (DMSO-d 6 ), δ : 7.47-7.78 (m, 4H), 8.06 (d, 1H), 8.32 (d, 2H), 8.57 (s, 1H), 8. 64 (d, 1H) Reference Example 31 Synthesis of 2-phenyl-6-methoxyquinoline-4-carboxylic acid The above-mentioned compound (0.63 g) was formed from 3.3 g of benzaldehyde, 3.83 g of p-anisidine and 2.37 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 3.93 (s, 3H), 7.50-7.60 (m, 4H), 8.08-8.15 (m, 2H), 8.24 (d, 2 H), 8.46 (s, 1H) Reference Example 32 Synthesis of 2-phenyl-7-methoxyquinoline-4-carboxylic acid The above-mentioned compound (2.82 g) was formed from 5.31 g of benzaldehyde, 6.16 g of m-anisidine and 4.40 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 3.98 (s, 3H), 7.37 (d, 1H), 7.58 (m, 4H), 8.27 (m, 3H), 8.57 (d, 1H) Reference Example 33 Synthesis of 2-phenyl-8-methoxyquinoline-4-carboxylic acid The above-mentioned compound (2.45 g) was formed from 3.47 g of benzaldehyde, 4.03 g of o-anisidine and 2.90 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 4.04 (s, 3H), 7.30 (d, 1H), 7.53-7.66 (m, 4H), 8.14 (d, 1H), 8. 28(d, 2H), 8.41 (s, 1H) Reference Example 34 Synthesis of 2-phenyl-5,7-dimethoxyquinoline-4-carboxylic acid The above-mentioned compound (0.93 g) was formed from 1.06 g of benzaldehyde, 1.68 g of 3,5-dimethoxyaniline and 0.90 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 3.91 (s, 3H), 3.95 (s, 3H), 6.73 (s, 1H), 7.12 (s, 1H), 7.54 (m, 3H), 7.83 (s, 1H), 8.29 (m, 2H) m.p. 240 - 240.5°C (decomp.) Reference Example 35 Synthesis of 2-(2'-methylphenyl)-5,7-dimethoxyquinoline-4-carboxylic acid The above-mentioned compound (0.86 g) was formed from 3.60 g of o-tolualdehyde, 4.60 g of 3,5-dimethoxyaniline and 2.64 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 2.35 (s, 3H), 3.83 (s, 3H), 3.89 (s, 3H), 6.58 (s, 1H), 6.95 (s, 1H), 7.01 (s, 1H), 7.30 (m, 3H), 7.40 (d, 1H) Reference Example 36 Synthesis of 2-phenyl-6,7-dimethoxyquinoline-4-carboxylic acid The above-mentioned compound (1.58 g) was formed from 3.18 g of o-benzaldehyde, 4.60 g of 3,4-dimethoxyaniline and 2.64 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 3.96 (s, 3H), 4.01 (s, 3H), 7.53 (m, 4H), 8.15 (s, 1H), 8.20 (s, 1H), 8.25 (s, 1H), 8.33 (s, 1H) Reference Example 37 Synthesis of 2-(2'-methylphenyl)-6,7-dimethoxyquinoline-4-carboxylic acid The above-mentioned compound (3.15 g) was formed from 2.40 g of o-tolualdehyde, 3.00 g of 3,4-dimethoxyaniline and 1.70 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 2.39 (s, 3H), 3.95 (s, 3H), 3.97 (s, 3H), 7.17-7.20 (m, 1H), 7. 33-7.38 (m, 2H), 7.48-7.51 (m, 2H), 7.88 (s, 1H), 8.20 (s, 1H) Reference Example 38 Synthesis of 2-phenyl-6,8-dimethoxyquinoline-4-carboxylic acid The above-mentioned compound (0.89 g) was formed from 2.12 g of benzaldehyde, 3.06 g of 2,4-dimethoxyaniline and 1.76 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 3.85 (s, 3H), 3.98 (s, 3H), 6.82 (s, 1H), 7.48 (m, 3H), 7.83 (s, 1H), 8.19 (d, 2H), 8.30 (s, 1H) Reference Example 39 Synthesis of 2-(2'-methylphenyl)-6,8-dimethoxyquinoline-4-carboxylic acid The above-mentioned compound (1.69 g) was formed from 2.40 g of o-tolualdehyde, 3.06 g of 2,4-dimethoxyaniline and 1.76 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 2.39 (s, 3H), 3.92 (s, 3H), 3.97 (s, 3H), 6.93 (d, 1H), 7.36 (m, 3H), 7.49 (m, 1H), 7.73 (d, 1H), 8.03 (s,1H) Reference Example 40 Synthesis of 2-(2'-methylphenyl)-5,8-dimethoxyquinoline-4-carboxylic acid The above-mentioned compound (3.44 g) was formed from 3.60 g of o-tolualdehyde, 4.60 g of 2,5-dimethoxyaniline and 2.64 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 2.34 (s, 3H), 3.79 (s, 3H), 3.89(s, 3H), 6.86 (d, 1H), 7.06 (d, 1H), 7.25 (s, 1H), 7.31 (m, 4H) m.p. 234 - 235°C (decomp.) Reference Example 41 Synthesis of 2-(2'-methylphenyl)-7,8-dimethoxyquinoline-4-carboxylic acid The above-mentioned compound (2.25 g) was formed from 2.30 g of o-tolualdehyde, 2.90 g of 2,3-dimethoxyaniline and 1.66 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 2.44 (s, 3H), 3.95 (s, 3H), 4.00 (s, 3H), 7.13-7.16 (m, 1H), 7. 33-7.45 (m, 2H), 7.54-7.57 (m, 1H), 7.66 (d, 1H), 7.88 (s, 1H), 8.46 (d, 1H) Reference Example 42 Synthesis of 2-phenyl-8-methoxyethyloxyquinoline-4-carboxylic acid The above-mentioned compound (1.40 g) was formed from 1.14 g of benzaldehyde, 1.80 g of 2-methoxyethyloxyaniline and 0.95 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 3.52 (s, 3H), 3.87 (t, 2H), 4.38 (t, 2H), 7.30 (d, 1H), 7.49-7. 60 (m, 4H), 8.17 (d, 1H), 8.29 (d, 2H), 8.42 (s, 1H) m.p. 128 - 133°C Reference Example 43 Synthesis of 2-(2'-methylphenyl)-7-methoxymethyloxyquinoline-4-carboxylic acid The above-mentioned compound (1.26 g) was formed from 2.74 g of o-tolualdehyde, 3.50 g of 3-methoxymethyloxyaniline and 2.00 g of pyruvic acid in the same manner as in Reference Example 24. 1 H-NMR(DMSO-d 6 ), δ : 2.40 (s, 3H), 3.41 (s, 3H), 5.41 (s, 2H), 7.34-7.63 (m, 6H), 7. 88 (s, 1H), 8.65 (d, 1H) Reference Example 44 Synthesis of ethyl 2-phenyl-8-nitroquinoline-4-carboxylate Benzaldehyde (19.5 g), 25.6 g of 2-nitroaniline and 16.2 g of pyruvic acid were mixed, and 10.4 ml of conc. sulfuric acid were added thereto dropwise at room temperature. After the mixture was stirred for 30 minutes, chloroform, water and aqueous ammonia were added to the reaction mixture, and the aqueous layer was extracted. This aqueous layer was acidified with conc. hydrochloric acid to obtain 25.0 g of crude 2-phenyl-8-nitroquinone-4-carboxylic acid as a dark red semi-solid. This semi-solid was dissolved in 300 ml of ethanol, and 37 ml of conc. sulfuric acid were added thereto. The mixture was heat-refluxed for 6 hours. After the reaction mixture was cooled to room temperature, the precipitate formed was collected by filtration, and recrystallized from methyl ethyl ketone to form 2.50 g of the above-mentioned compound. 1 H-NMR(DMSO-d 6 ), δ : 1.46 (t, 3H), 4.51 (q, 2H), 7.56-7.65 (m, 3H), 7.83-7.89 (t, 1 H), 8.23-8.28 (m, 2H), 8.35 (d, 1H), 8.64 (s, 1H), 8.81 (d, 1H) m.p. 138 - 140°C Reference Example 45 Synthesis of 2-phenyl-8-nitroquinone-4-carboxylic acid Ethyl 2-phenyl-8-nitroquinone-4-carboxylic acid (1.09 g) formed in Reference Example 44 was suspended in 8 ml of ethanol, and 1.2 M (6 ml) of a sodium hydroxide aqueous solution was added thereto at room temperature. The mixture was then stirred at approximately 40°C for 2 hours. The reaction mixture was cooled with ice, and neutralized with dilute hydrochloric acid. The crystals precipitated were collected by filtration, washed with water, and dried to obtain 0.97 g of the above-mentioned compound. 1 H-NMR(DMSO-d 6 ), δ : 7.60 (m, 3H), 7.86 (t, 1H), 8.28 (m, 2H), 8.38 (d, 1H), 8.66 (s, 1H), 8.91 (d, 1H) Reference Example 46 Synthesis of ethyl 2-phenyl-8-aminoquinoline-4-carboxylate Ethyl 2-phenyl-8-nitroquinone-4-carboxylate (2.0 g) formed in Reference Example 44 was hydrogenated in DMF in the presence of Pd/C in a usual manner to obtain 1.70 g of the above-mentioned compound. 1 H-NMR(DMSO-d 6 ), δ : 1.43 (t, 3H), 4.50 (q, 2H), 6.96 (d,1H), 7.36 (t, 1H), 7.51-7. 62 (m, 4H), 8.27-8.37 (m, 3H) m.p. 66 - 69°C Reference Example 47 Synthesis of ethyl 2-phenyl-8-acetylaminoquinoline-4-carboxylate Ethyl 2-phenyl-8-aminoquinoline-4-carboxylate (0.82 g) formed in Reference Example 46 was acetylated in a usual manner to obtain 0.75 g of the above-mentioned compound. 1 H-NMR(DMSO-d 6 ), δ : 1.44 (t, 3H), 2.35 (s, 3H), 4.50 (q, 2H), 7.63 (m, 4H), 8.12 (d, 1H), 8.44 (m, 2H), 8.52 (s, 1H), 8.66 (d, 1H), 10.12 (s, 1H) m.p. 141.5 - 142°C Reference Example 48 Synthesis of 2-phenyl-8-acetylaminoquinoline-4-carboxylic acid Ethyl 2-phenyl-8-acetylaminoquinoline-4-carboxylate (0.67 g) formed in Reference Example 47 was suspended in 6 ml of methanol, and 4 ml (1.1 M) of a sodium hydroxide aqueous solution were added thereto at room temperature. The mixture was then stirred at approximately 40°C for 1 hour. The reaction mixture was cooled with ice, and neutralized with dilute hydrochloric acid. The precipitate was collected by filtration, and dried to obtain 0.46 g of the above-mentioned compound. 1 H-NMR(DMSO-d 6 ), δ : 2.35 (s, 3H), 7.54-7.68 (m, 4H), 8.27 (d, 1H), 8.39 (dd, 2H), 8. 52 (s, 1H), 8.65 (d, 1H), 10.13 (s, 1H) m.p. 254 - 255°C (decomp.) Reference Example 49 Synthesis of ethyl 2-phenyl-8-methanesulfonylaminoquinoline-4-carboxylate Ethyl 2-phenyl-8-aminoquinoline-4-carboxylate (1.02 g) formed in Reference Example 46 was methanesulfonylated in a usual manner to obtain 1.16 g of the above-mentioned compound. 1 H-NMR(DMSO-d 6 ), δ : 1.44 (t, 3H), 3.17 (s, 3H), 4.51 (q, 2H), 7.63 (m, 4H), 7.72 (t, 1H), 7.83 (d, 1H), 8.44 (s, 1H), 8.46 (s, 1H), 8.54 (s, 1H), 9.63 (s, 1H) m.p. 145.5 - 146.2°C Reference Example 50 Synthesis of 2-phenyl-8-methanesulfonylaminoquinoline-4-carboxylate Ethyl 2-phenyl-8-methanesulfonylaminoquinoline-4-carboxylate (0.99 g) obtained in Reference Example 49 was hydrolyzed in the same manner as in Reference Example 48 to form 0.38 g of the above-mentioned compound. 1 H-NMR(DMSO-d 6 ), δ : 3.17 (s, 3H), 7.53-7.72 (m, 4H), 7.82 (d, 1H), 8.37 (d, 1H), 8. 45 (d, 2H), 8.53 (s, 1H), 9.61 (s, 1H) m.p. 263 - 264°C (decomp.) Reference Example 51 Synthesis of 2-(2'-methoxymethyloxyphenyl)quinoline-4-carboxylic acid The above-mentioned compound (1.53 g) was formed from 1.47 g of isatin and 3.64 g of 2-methoxymethyloxyacetophenone in the same manner as in Reference Example 1. 1 H-NMR(DMSO-d 6 ), δ : 3.58 (s, 3H), 5.64 (s, 2H), 7.05 (m, 2H), 7.51 (d, 1H), 7.60 (t, 1H), 7.79 (t, 1H), 7.91 (m, 1H), 8.20 (d, 2H), 8.70 (s, 1H) Example 1 Synthesis of 2-phenylquinoline-4-carbonylguanidine [A] 2-Phenylquinoline-4-carboxylic acid (1.99 g) and 1.43 g of 1,1'-carbonyldiimidazole were added to 20 ml of anhydrous DMF, and the mixture was stirred at room temperature for 2 hours under a nitrogen atmosphere. [B] A mixture of 4.60 g of guanidine hydrochloride and 2.90 g of sodium methoxide was stirred in 30 ml of anhydrous methanol at room temperature for 1 hour. Then, the reaction mixture was filtered in a nitrogen stream, and the crystals were washed with methanol. The filtrate was concentrated to dryness under reduced pressure, and anhydrous benzene was added to the residue. The mixture was reconcentrated, and then dried under reduced pressure. [C] The solution obtained in [A] was added to the dry guanidine obtained in [B] under a nitrogen atmosphere while being cooled with ice, and the mixture was stirred at room temperature for 12 hours. Subsequently, the reaction solution was concentrated under reduced pressure, and ice water was added to the residue. The mixture was further stirred for 30 minutes. The precipitate was collected by filtration, and the crystals were washed with water and then with a small amount of ethyl ether. The crystals were further washed with 10 ml of ethanol, and dried to obtain 1.85 g of the above-mentioned compound. m.p. 268°C (decomp.) Example 2 Synthesis of 2-(4'-methylphenyl)quinoline-4-carbonylguanidine The above-mentioned compound (1.35 g) was formed as a white crystal in the same manner as in Example 1 using 2.0 g of 2-(4'-methylphenyl)quinoline-4-carboxylic acid obtained in Reference Example 1 as a starting material. m.p. 244.3 - 244.5°C Example 3 Synthesis of 2-(3'-methylphenyl)quinoline-4-carbonylguanidine The above-mentioned compound (0.60 g) was formed in the same manner as in Example 1 using 0.53 g of 2-(3'-methylphenyl)quinoline-4-carboxylic acid obtained in Reference Example 2 as a starting material. m.p. 248°C (decomp.) Example 4 Synthesis of 2-(2'-methylphenyl)quinoline-4-carbonylguanidine The above-mentioned compound (0.75 g) was formed in the same manner as in Example 1 using 0,79 g of 2-(2'-methylphenyl)quinoline-4-carboxylic acid obtained in Reference Example 3 as a starting material. m.p. 257.5 - 258.5°C (decomp.) Example 5 Synthesis of 2-(2'-isopropylphenyl)quinoline-4-carbonylguanidine The above-mentioned compound (1.17 g) was formed as a brown crystal in the same manner as in Example 1 using 1.46 g of 2-(2'-isopropylphenyl)quinoline-4-carboxylic acid obtained in Reference Example 26 as a starting material. m.p. 224 - 230°C Example 6 Synthesis of 2-(2',4'-dimethylphenyl)quinoline-4-carbonylguanidine The above-mentioned compound (1.06 g) was formed as a brown crystal in the same manner as in Example 1 using 0.96 g of 2-(2',4'-dimethylphenyl)quinoline-4-carboxylic acid obtained in Reference Example 4 as a starting material. m.p. 226 - 233°C (decomp.) Example 7 Synthesis of 2-(3',4'-dimethylphenyl)quinoline-4-carbonylguanidine The above-mentioned compound (2.82 g) was formed as a white crystal in the same manner as in Example 1 using 3.3 g of 2-(3',4'-dimethylphenyl)quinoline-4-carboxylic acid obtained in Reference Example 5 as a starting material. m.p. 240 - 243°C (decomp.) Example 8 Synthesis of 2-(2',4',6'-trimethylphenyl)quinoline-4-carbonylguanidine The above-mentioned compound (0.15 g) was formed in the same manner as in Example 1 using 0.14 g of 2-(2',4',6'-trimethylphenyl)quinoline-4-carboxylic acid obtained inReference Example 6 as a starting material. m.p. 247 - 250°C (decomp.) Example 9 Synthesis of 2-(4'-tert-butylphenyl)quinoline-4-carbonylguanidine The above-mentioned compound (0.69 g) was formed in the same manner as in Example 1 using 0.61 g of 2-(4'-tert-butylphenyl)quinoline-4-carboxylic acid obtained in Reference Example 7 as a starting material. m.p. 272°C (decomp.) Example 10 Synthesis of 2-(3'-trifluoromethylphenyl)quinoline-4-carbonylguanidine The above-mentioned compound (1.30 g) was formed in the same manner as in Example 1 using 1.59 g of 2-(3'-trifluoromethylphenyl)quinoline-4-carboxylic acid obtained in Reference Example 8 as a starting material. m.p. 263°C (decomp.) Example 11 Synthesis of 2-(2'-trifluoromethylphenyl)quinoline-4-carbonylguanidine The above-mentioned compound (1.23 g) was formed in the same manner as in Example 1 using 1.59 g of 2-(2'-trifluoromethylphenyl)quinoline-4-carboxylic acid obtained in Reference Example 9 as a starting material. m.p. 251 - 252°C (decomp.) Example 12 Synthesis of 2-(4'-bromophenyl)quinoline-4-carbonylguanidine The above-mentioned compound (1.40 g) was formed in the same manner as in Example 1 using 2.70 g of 2-(4'-bromophenyl)quinoline-4-carboxylic acid obtained in Reference Example 10 as a starting material. m.p. 243 - 244°C (decomp.) Example 13 Synthesis of 2-(4'-fluorophenyl)quinoline-4-carbonylguanidine The above-mentioned compound (1.28 g) was formed as a white crystal in the same manner as in Example 1 using 1.70 g of 2-(4'-fluorophenyl)quinoline-4-carboxylic acid obtained in Reference Example 11 as a starting material. m.p. 238 - 241°C (decomp.) Example 14 Synthesis of 2-(2'-chlorophenyl)quinoline-4-carbonylguanidine The above-mentioned compound (0.25 g) was formed in the same manner as in Example 1 using 0.83 g of 2-(2'-chlorophenyl)quinoline-4-carboxylic acid obtained in Reference Example 12 as a starting material. m.p. 250 - 250.5°C (decomp.) Example 15 Synthesis of 2-(4'-methoxyphenyl)quinoline-4-carbonylguanidine The above-mentioned compound (1.20 g) was formed as a white crystal in the same manner as in Example 1 using 1.54 g of 2-(4'-methoxyphenyl)quinoline-4-carboxylic acid obtained in Reference Example 13 as a starting material. m.p. 244.3 - 244.7°C (decomp.) Example 16 Synthesis of 2-(2'-methoxyphenyl)quinoline-4-carbonylguanidine The above-mentioned compound (0.41 g) was formed in the same manner as in Example 1 using 0.87 g of 2-(2'-methoxyphenyl)quinoline-4-carboxylic acid obtained in Reference Example 14 as a starting material. m.p. 254 - 256.5°C (decomp.) Example 17 Synthesis of 2-(2',6'-dimethoxyphenyl)quinoline-4-carbonylguanidine The above-mentioned compound (20 mg) was formed in the same manner as in Example 1 using 0.52 g of 2-(2',6'-dimethoxyphenyl)quinoline-4-carboxylic acid obtained in Reference Example 15 as a starting material. m.p. 258°C (decomp.) Example 18 Synthesis of 2-(4'-trifluoromethoxyphenyl)quinoline-4-carbonylguanidine The above-mentioned compound (1.88 g) was formed in the same manner as in Example 1 using 1.67 g of 2-(4'-trifluoromethoxyphenyl)quinoline-4-carboxylic acid obtained in Reference Example 16 as a starting material. m.p. 243°C (decomp.) Example 19 Synthesis of 2-(3'-nitrophenyl)quinoline-4-carbonylguanidine The above-mentioned compound (0.76 g) was formed as a brown crystal in the same manner as in Example 1 using 0.75 g of 2-(3'-nitrophenyl)quinoline-4-carboxylic acid obtained in Reference Example 25 as a starting material. m.p. 184 - 190°C Example 20 Synthesis of 2-(3'-aminophenyl)quinoline-4-carbonylguanidine 2-(3'-Nitrophenyl)quinoline-4-carbonylguanidine (0.40 g) formed in Example 19 was dissolved in 40 ml of methanol, and hydrogenated under normal pressure for 5.5 hours in the presence of 0.3 g of Pd/C (purity 10%). The catalyst was filtered off from the reaction solution, and the filtrate was concentrated to obtain 0.45 g of the above-mentioned compound as a brown crystal. m.p. 209 - 210°C Example 21 Synthesis of 2-phenyl-3-methylquinoline-4-carbonylguanidine The above-mentioned compound (1.06 g) was formed in the same manner as in Example 1 using 1.05 g of 2-phenyl-3-methylquinoline-4-carboxylic acid obtained in Reference Example 17 as a starting material. m.p. 270°C or higher Example 22 Synthesis of 2-phenyl-6-methylquinoline-4-carbonylguanidine The above-mentioned compound (0.52 g) was formed in the same manner as in Example 1 using 0.50 g of 2-phenyl-6-methylquinoline-4-carboxylic acid obtained in Reference Example 24 as a starting material. m.p. 276.5°C Example 23 Synthesis of 2-phenyl-7-methylquinoline-4-carbonylguanidine The above-mentioned compound (0.86 g) was formed as a pale red crystal in the same manner as in Example 1 using 0.92 g of 2-phenyl-7-methylquinoline-4-carboxylic acid obtained in Reference Example 27 as a starting material. m.p. 250°C or higher Example 24 Synthesis of 2-phenyl-8-methylquinoline-4-carbonylguanidine The above-mentioned compound (1.50 g) was formed in the same manner as in Example 1 using 1.32 g of 2-phenyl-8-methylquinoline-4-carboxylic acid obtained in Reference Example 28 as a starting material. m.p. 221°C (decomp.) Example 25 Synthesis of 2-phenyl-6-isopropylquinoline-4-carbonylguanidine The above-mentioned compound (0.33 g) was formed in the same manner as in Example 1 using 0.98 g of 2-phenyl-6-isopropylquinoline-4-carboxylic acid obtained in Reference Example 29 as a starting material. m.p. 254.5 - 255°C (decomp.) Example 26 Synthesis of 2-phenyl-6-fluoroquinoline-4-carbonylguanidine The above-mentioned compound (0.54 g) was formed in the same manner as in Example 1 using 1.07 g of 2-phenyl-6-fluoroquinoline-4-carboxylic acid obtained in Reference Example 18 as a starting material. m.p. 258°C (decomp.) Example 27 Synthesis of 2-phenyl-6-iodoquinoline-4-carbonylguanidine The above-mentioned compound (1.20 g) was formed in the same manner as in Example 1 using 1.13 g of 2-phenyl-6-iodoquinoline-4-carboxylic acid obtained in Reference Example 19 as a starting material. m.p. 270°C or higher Example 28 Synthesis of 2-phenyl-5-chloroquinoline-4-carbonylguanidine The above-mentioned compound (0.41 g) was formed as a brown crystal in the same manner as in Example 1 using 0.42 g of 2-phenyl-5-chloroquinoline-4-carboxylic acid obtained in Reference Example 20 as a starting material. m.p. 229 - 234°C Example 29 Synthesis of 2-phenyl-6-chloroquinoline-4-carbonylguanidine The above-mentioned compound (1.07 g) was formed as a brown crystal in the same manner as in Example 1 using 1.0 g of 2-phenyl-6-chloroquinoline-4-carboxylic acid obtained in Reference Example 21 as a starting material. m.p. 250°C or higher Example 30 Synthesis of 2-phenyl-7-chloroquinoline-4-carbonylguanidine The above-mentioned compound (1.12 g) was formed as a brown crystal in the same manner as in Example 1 using 1.0 g of 2-phenyl-7-chloroquinoline-4-carboxylic acid obtained in Reference Example 22 as a starting material. m.p. 229 - 231°C Example 31 Synthesis of 2-phenyl-8-chloroquinoline-4-carbonylguanidine The above-mentioned compound (0.11 g) was formed in the same manner as in Example 1 using 0.40 g of 2-phenyl-8-chloroquinoline-4-carboxylic acid obtained in Reference Example 30 as a starting material. m.p. 220°C (decomp.) Example 32 Synthesis of 2-phenyl-6-chloro-8-methylquinoline-4-carbonylguanidine The above-mentioned compound (1.00 g) was formed in the same manner as in Example 1 using 0.89 g of 2-phenyl-6-chloro-8-methylquinoline-4-carboxylic acid obtained in Reference Example 23 as a starting material. m.p. 159 - 160°C (decomp.) Example 33 Synthesis of 2-phenyl-6- methoxyquinoline-4-carbonylguanidine The above-mentioned compound (0.68 g) was formed as a white crystal in the same manner as in Example 1 using 0.63 g of 2-phenyl-6-methoxyquinoline-4-carboxylic acid obtained in Reference Example 31 as a starting material. m.p. 250 - 251°C Example 34 Synthesis of 2-phenyl-7-methoxyquinoline-4-carbonylguanidine The above-mentioned compound (1.60 g) was formed in the same manner as in Example 1 using 1.40 g of 2-phenyl-7-methoxyquinoline-4-carboxylic acid obtained in Reference Example 32 as a starting material. m.p. 263.5 - 264°C Example 35 Synthesis of 2-phenyl-8-methoxyquinoline-4-carbonylguanidine (Method 1) The above-mentioned compound (2.40 g) was formed as a white crystal in the same manner as in Example 1 using 2.17 g of 2-phenyl-8-methoxyquinoline-4-carboxylic acid obtained in Reference Example 33 as a starting material. (Method 2) An anhydrous THF (50 ml) solution containing 4.0 g of methyl 2-phenyl-8-methoxyquinoline-4-carboxylate formed from 2-phenyl-8-methoxyquinoline-4-carboxylic acid in a usual manner was added to guanidine formed from 6.50 g of guanidine hydrochloride in the same manner as in [C] of Example 1 at room temperature. Subsequently, the mixture was heat-refluxed for 3 hours, and cooled to room temperature. The reaction mixture was then concentrated under reduced pressure, and ice water was added to the residue. The precipitate formed was collected by filtration, washed with ethyl ether, and dried to obtain 3.59 of the above-mentioned compound as a white crystal. m.p. 232 - 235°C (decomp.) Example 36 Synthesis of 2-phenyl-5,7-dimethoxyquinoline-4-carbonylguanidine The above-mentioned compound (0.16 g) was formed in the same manner as in Example 1 using 0.77 g of 2-phenyl-5,7-dimethoxyquinoline-4-carboxylic acid obtained in Reference Example 34 as a starting material. m.p. 273.5°C (decomp.) Example 37 Synthesis of 2-(2'-methylphenyl)-5,7-dimethoxyquinone-4-carbonylguanidine 2-(2'-Methylphenyl)-5,7-dimethoxyquinoline-4-carboxylic acid (0.80 g) formed in Reference Example 35 was suspended in 20 ml of benzene, and 1.76 g of thionyl chloride were added thereto. The mixture was heat-refluxed for 3 hours. The reaction mixture was cooled to room temperature, and then concentrated under reduced pressure. Benzene was added to the residue, and the resulting mixture was concentrated, and then dissolved in 5 ml of DMF. Guanidine formed from 0.71 g of guanidine hydrochloride was suspended in 10 ml of DMF in the same manner as in [C] of Example 1, and the above-mentioned DMF solution was added thereto dropwise at room temperature. The reaction mixture was stirred at room temperature for 1 hour, and then concentrated. Ice water was added to the residue, and the precipitate was collected by filtration to obtain crystals. The crystals were further purified through silica-gel column chromatography (mixture of methanol and chloroform at a ratio of 1:10) to form 0.29 g of the above-mentioned compound. m.p. 262 - 262.5°C (decomp.) Example 38 Synthesis of 2-phenyl-6,7-dimethoxyquinoline-4-carbonylguanidine The above-mentioned compound (1.70 g) was formed in the same manner as in Example 1 using 1.60 g of 2-phenyl-6,7-dimethoxyquinoline-4-carboxylic acid obtained in Reference Example 36 as a starting material. m.p. 245°C (decomp.) Example 39 Synthesis of 2-(2'-methylphenyl)-6,7-dimethoxyquinoline-4-carbonylguanidine The above-mentioned compound (1.08 g) was formed as a white crystal in the same manner as in Example 1 using 2.57 g of 2-(2'-methylphenyl)-6,7-dimethoxyquinoline-4-carboxylic acid obtained in Reference Example 37 as a starting material. m.p. 234 - 235°C Example 40 Synthesis of 2-phenyl-6,8-dimethoxyquinoline-4-carbonylguanidine The above-mentioned compound (0.21 g) was formed in the same manner as in Example 1 using 0.80 g of 2-phenyl-6,8-dimethoxyquinoline-4-carboxylic acid obtained in Reference Example 38 as a starting material. m.p. 256°C (decomp.) Example 41 Synthesis of 2-(2'-methylphenyl)-6,8-dimethoxyquinoline-4-carbonylguanidine The above-mentioned compound (1.11 g) was formed in the same manner as in Example 1 using 1.29 g of 2-(2'-methylphenyl)-6,8-dimethoxyquinoline-4-carboxylic acid obtained in Reference Example 39 as a starting material. m.p. 227 - 229°C (decomp.) Example 42 Synthesis of 2-(2'-methylphenyl)-5,8-dimethoxyquinoline-4-carbonylguanidine The above-mentioned compound (0.44 g) was formed in the same manner as in Example 1 using 0.49 g of 2-(2'-methylphenyl)-5,8-dimethoxyquinoline-4-carboxylic acid obtained in Reference Example 40 as a starting material. m.p. 241°C Example 43 Synthesis of 2-(2'-methylphenyl)-7,8-dimethoxyquinoline-4-carbonylguanidine The above-mentioned compound (1.56 g) was formed as a yellow crystal in the same manner as in Example 1 using 2.20 g of 2-(2'-methylphenyl)-7,8-dimethoxyquinoline-4-carboxylic acid obtained in Reference Example 41 as a starting material. m.p. 238 - 239°C Example 44 Synthesis of 2-phenyl-8-methoxyethyloxyquinoline-4-carbonylguanidine The above-mentioned compound (1.00 g) was formed as a brown crystal in the same manner as in Example 1 using 1.30 g of 2-phenyl-8-methoxyethyloxyquinoline-4-carboxylic acid obtained in Reference Example 42 as a starting material. m.p. 218 - 220°C Example 45 Synthesis of 2-(2'-methylphenyl)-7-methoxymethyloxyquinoline-4-carbonylguanidine The above-mentioned compound (1.30 g) was formed as a brown crystal in the same manner as in Example 1 using 1.20 g of 2-(2'-methylphenyl)-7-methoxymethyloxyquinoline-4-carboxylic acid obtained in Reference Example 43 as a starting material. m.p. 186 - 190°C Example 46 Synthesis of 2-(2'-methylphenyl)-7-hydroxyquinoline-4-carbonylguanidine 2-(2'-Methylphenyl)-7-methoxymethyloxyquinoline-4-carbonylguanidine (0.9 g) formed in Example 45 was heat-stirred in 20 ml (0.5 M) of an isopropyl alcohol solution of hydrochloric acid at approximately 60°C for 3.5 hours. The reaction mixture was allowed to cool, then neutralized with a 5 % sodium hydroxide aqueous solution, and concentrated. The residue was filtered, and the crystals obtained were washed with water, and dried to obtain 0.40 g of the above-mentioned compound as a brown crystal. m.p. 202 - 208°C Example 47 Synthesis of 2-phenyl-8-nitroquinoline-4-carbonylguanidine The above-mentioned compound (1.07 g) was formed in the same manner as in Example 1 using 0.88 g of 2-phenyl-8-nitroquinoline-4-carboxylic acid obtained in Reference Example 45 as a starting material. m.p. 236 - 236.5°C (decomp.) Example 48 Synthesis of 2-phenyl-8-aminoquinoline-4-carbonylguanidine The above-mentioned compound (0.23 g) was formed by hydrogenating 2-phenyl-8-nitroquinoline-4-carbonylguanidine obtained in Example 47 as a starting material under normal pressure in the same manner as in Example 20. m.p. 199 - 200.5°C (decomp.) Example 49 Synthesis of 2-phenyl-8-acetylaminoquinoline-4-carbonylguanidine The above-mentioned compound (0.26 g) was formed in the same manner as in Example 1 using 0.31 g of 2-phenyl-8-acetylaminoquinoline-4-carboxylic acid obtained in Reference Example 48 as a starting material. m.p. 246 - 246.5°C (decomp.) Example 50 Synthesis of 2-phenyl-8-methanesulfonylaminoquinoline-4-carbonylguanidine The above-mentioned compound (0.33 g) was formed in the same manner as in Example 1 using 0.31 g of 2-phenyl-8-methanesulfonylaminoquinoline-4-carboxylic acid obtained in Reference Example 50 as a starting material. m.p. 255.5 - 256.0°C (decomp.) Example 51 Synthesis of 2-(2'-methoxymethyloxyphenyl) quinoline-4-carbonylguanidine The above-mentioned compound (0.93 g) was formed in the same manner as in Example 1 using 1.43 g 2-(2'-methoxymethyloxyphenyl)quinoline-4-carboxylic acid obtained in Reference Example 51 as a starting material. m.p. 219 - 220°C (decomp.) Example 52 Synthesis of 2-(2'-hydroxyphenyl)quinoline-4-carbonylguanidine hydrochloride 2-(2'-Methoxymethyloxyphenyl)quinoline-4-carbonylguanidine (0.51 g) formed in Example 51 was stirred in 24 ml (5 M) of an isopropyl alcohol solution of hydrochloric acid at 70°C for 3 hours. The reaction mixture was cooled with ice, and the precipitate was collected by filtration, and dried to obtain 0.50 g of the above-mentioned compound. m.p. 270°C or higher Example 53 Synthesis of 2-phenylquinoline-4-carbonylguanidine hydrochloride 2-Phenylquinoline-4-carbonylguanidine (1.08 g) formed in Example 1 was suspended in 10 ml of ethanol, and 6 ml (1 N) of an ethanol solution of hydrochloric acid were added thereto dropwise at room temperature. Thirty minutes later, ethyl ether was added to the reaction solution, and the crystals were collected by filtration, and dried to obtain 1.12 g of the above-mentioned compound. m.p. 278 - 279°C (decomp.) Example 54 Synthesis of 2-(2'-isopropylphenyl)quinoline-4-carbonylguanidine methanesulfonate 2-(2'-Isopropylphenyl)quinoline-4-carbonylguanidine (1.1 g) formed in Example 5 was suspended in 25 ml of ethanol, and 7.5 ml (1 M) of an ethanol solution of methanesulfonic acid were added thereto dropwise while being cooled with ice. Ten minutes later, ethyl ether was added thereto, and the crystals precipitated were collected by filtration, and dried to obtain 1.10 g of the above-mentioned compound as a white crystal. m.p. 146 - 154°C The compounds formed in Examples 1 to 51 were converted into hydrochlorides in the same manner as in Example 53 or into methanesulfonates in the same manner as in Example 54. The analytical data of the compounds formed in Examples 1 to 52 are shown in Table 1. Example No. N M R (Solvent) ; δ ppm IR (KBr, cm -1 ) 1 (DMSO-d 6 ) ; 7.48-7.61 (m, 3H), 7.76 (t, 1H), 8.09 (d, 1H), 8.25-8.33(m, 3H), 8.30 (s, 1H), 8.64(d, 1H) 3377, 1593, 1524, 1380, 1314, 771 2 (DMSO-d 6 ) ; 2.40 (s, 3H), 7.37 (d, 2H), 7.53-7.59 (m, 1H), 7.72-7.78 (m, 1H), 8.06 (d, 1H), 8.17 (d, 2H), 8.26 (s, 1H), 8.60(d, 1H) 3378, 1585, 1530, 1381, 1316, 819, 798,760 3 (DMSO-d 6 ) ; 2.38 (s, 3H), 7.32 (d, 1H), 7.45 (t, 1H), 7.56 (t, 1H), 7.75 (t, 1H), 7.99-8.09 (m, 3H), 8.28 (s, 1H), 8.63 (d, 1H) 3366, 1578, 1522, 1457, 1376, 1314 4 (DMSO-d 6 ) ; 2.38 (s, 3H), 7.36 (m, 3H), 7.50 (m, 1H), 7.62 (t, 1H), 7.79 (t, 1H), 7.90 (s, 1H), 8.05 (d, 1H), 8.14 (d, 1H) 3449, 1654, 1608, 1523, 1457, 1374, 1308, 769 5 (DMSO-d 6 ) ; 1.17 (d, 6H), 3.11-3.24 (m, 1H), 7.31-7.18 (m, 6H), 7.83 (s, 1H), 8.02 (d, 1H), 8. 30 (s, 4H), 8.75 (d, 1H) 3449, 1654, 1609, 1523, 1375, 1306, 1063, 811, 763 6 (DMSO-d 6 ); 2.37 (s, 6H), 7.16 (d, 2H), 7.39 (d, 1H), 7.60(t, 1H), 7.76(t, 1H), 7.84(s, 1H), 8.04 (d, 1H), 8.27 (s, 4H), 8.68 (d, 1H) 3447, 2975, 1649, 1578, 1517, 1365, 1303, 1091, 1050, 897, 882, 810,767 7 (DMSO-d 6 ) ; 2.31 (s, 3H), 2.36 (s, 3H), 7.31 (d, 1H), 7.55 (t, 1H), 7.70-7.76 (m, 1H), 7.96 -8.07 (m, 2H), 8.25 (s, 1H), 8.31 (s, 4H), 8.60 (d, 1H) 3376, 1584, 1541, 1457, 1374, 758 8 (DMSO-d 6 ) ; 1.95 (s, 6H), 2.31 (s, 3H), 6.98 (s, 2H), 7.48-7.64 (m, 2H), 7.76 (t, 1H), 8.02 (d, 1H), 8.26 (s, 4H), 8.12(d, 1H) 3422, 1637, 1578, 1560, 1522, 1457 9 (DMSO-d 6 ) ; 1.35 (s, 9H), 7.57 (d, 3H), 7.74 (t, 1H), 8.06(d, 1H), 8.18(d, 2H), 8.25(s, 1H), 8.60-8.63 (m, 1H) 3447, 2963, 1610, 1523, 1377, 1314, 766 10 (DMSO-d 6 ); 7.65 (t, 1H), 7.82 (m, 3H), 8.16 (d, 1H), 8.36 (s, 1H), 8.57 (m, 3H) 3368, 1583, 1523, 1437, 1384, 1341, 1233,1168,1126, 1073,888,800,758 698 11 (DMSO-d 6 ) ; 7.70 (m, 4H), 7.85 (m, 2H), 7.92 (d, 1H), 8.06(d, 1H), 8.69(d, 1H) 3422, 1617, 1522, 1375, 1316, 1174, 1128, 771 12 (DMSO-d 6 ) ; 6.96(br s,1H), 7.60(m, 1H), 7.16 (d, 2H), 8.08 (d, 1H), 8.24 (d, 2H), 8.29 (s, 1H), 8.61 (d, 2H) 3371, 1584, 1529, 1399, 1378, 1312, 1076, 1009, 759 (DMSO-d 6 ) ; 7.38 (t, 2H), 7.58-7.62 (m, 1H), 3394, 1579, 1517, 13 7.14-7.80 (m, 1H), 8.08 (d, 1H), 8.25-8.34 (m, 3H), 8.60 (d, 1H) 1382, 1315, 1234, 841, 812, 760 14 (DMSO-d 6 ) ; 7.12 (t, 1H), 7.19 (d, 1H), 7.47 (t, 1H), 7.57 (d, 1H), 7.75 (m, 2H), 8.05 (d, 1H), 8.12 (s, 1H), 8.31 (s, 4H), 8.65 (d, 1H) 3445, 1602, 1525, 1460, 1375, 1312, 1247, 1025, 759 15 (DMSO-d 6 ) ; 3.86 (s, 3H), 7.12 (d, 2H), 7.53-7.59 (m, 1H), 7.72-7.78 (m, 1H), 8.06 (d, 1H), 8.20 (s, 1H), 8.22 (d, 2H), 8.55 (d, 1H) 3367, 1585, 1522, 1380, 1180, 1027, 833, 800, 759 16 (DMSO-d 6 ) ; 3.54 (s, 3H), 7.12 (t, 1H), 7.20 (d, 1H), 7.49 (t, 1H), 7.59 (t, 1H), 7.76 (m, 2H), 8.06 (d, 1H), 8.10 (s, 1H), 8.63 (d, 1H) 3855, 1602, 1524, 1459, 1374, 1312, 1247, 1025, 758 17 The 2CH 3 SO 3 H salt was measured. (DMSO-d 6 ) ; 2.39 (s, 6H), 3.71 (s, 6H), 6.85 (s, 1H), 6.88(s, 1H), 7.51 (t, 1H), 7.86(t, 1H), 7.88(s, 1H), 7.97(t, 1H), 8.18(d, 1H), 8.30 (d, 1H) 3380, 3108, 1722, 1598, 1234, 1112, 1043, 785 18 (DMSO-d 6 ) ; 7.58 (m, 3H), 7.79 (t, 1H), 8.10 (d, 1H), 8.31 (s, 1H), 8.38 (d, 2H), 8.63 (d, 1H) 3381, 1585, 1522, 1378, 1258 19 (DMSO-d 6 ) ; 7.61-7.64 (m, 1H), 7.81-7.90 (m, 2H), 8.13 (d, 1H), 8.31 (s, 4H), 8. 34-8.40 (m, 2H), 8.63-8.73 (m, 2H), 9.07-9.08 (m, 1H) 3374, 1653, 1526, 1349, 809, 696 (DMSO-d 6 ) ; 6.68-6.71 (m, 1H), 7.14-7.36 (m 3378, 1583, 1380, 20 , 2H), 7.51-7.58 (m, 2H), 7.71-7.76 (m, 1H), 8.03 (d, 1H), 8.18 (s, 1H), 8.31 (s, 4H), 8.63 (d, 1H) 882 21 (DMSO-d 6 ) ; 2.30 (s, 3H), 7.52 (m, 6H), 7.65 (m, 1H), 7.90 (m, 2H) 3855, 3056, 1671, 1560, 1396, 1334, 767 22 (DMSO-d 6 ) ; 3.32 (s, 3H), 7.51 (m, 4H), 7.99 (d, 1H), 8.25 (m, 3H), 8.39 (s, 1H) 3369, 1654, 1541, 1508, 1457, 1378, 1318 23 (DMSO-d 6 ) ; 7.43-7.61 (m, 4H), 7.90 (s, 1H), 8.19-8.23 (m, 3H), 8.50 (d, 1H) 3376, 1655, 1592, 1524, 1457, 1375, 1316,1069,886, 826, 769, 701, 669 24 (DMSO-d 6 ) ; 2.83 (s, 3H), 7.57 (m, 5H), 8.27 (m, 3H), 8.39 (d, 1H) 3451, 3365, 1656, 1587, 1559, 1523, 1373, 1317, 763 25 (DMSO-d 6 ) ; 1.32 (d, 6H), 3.12 (m, 1H), 7.56 (m, 3H), 7.72 (m, 1H), 8.01 (d, 1H), 8.25 (m, 2H), 8.27 (s, 1H), 8.45 (m, 1H) 3455, 3326, 2962, 1653, 1602, 1518, 1372, 1315,769, 705 26 (DMSO-d 6 ) ; 7.58 (m, 3H), 7.71 (m, 1H), 8.17 (m, 1H), 8.26 (d, 2H), 8.48 (s, 1H), 8.59 (m, 1H) 3381,1577,1552, 1363, 1318, 1236, 835, 703 27 (DMSO-d 6 ) ; 7.57 (m, 2H), 7.90 (d, 1H), 8.03 (m, 1H), 8.22 (s, 1H), 8.25 (m, 2H), 8.35 (s, 1H), 9.08 (m, 1H) 3375, 1595, 1541, 1457, 1390, 1317 28 (DMSO-d 6 ) ; 7.53-7.76(m, 6H), 7.92 (s, 1H), 8.06 (d, 1H), 8.30(s, 4H), 8. 30-8. 36 (m, 1H) 3448, 1654, 1596, 1522, 1457, 1362, 1311, 1197, 1071, 777, 698 29 (DMSO-d 6 ) ; 7.50-7.62 (m, 3H), 7.16-7.80 (m, 1H), 8.12 (d, 1H), 8.25 (d, 2H), 8.43(s, 1H), 8.80(s, 1H) 3378, 1590, 1530, 1492, 1453, 1397, 1378, 1317, 1065, 887, 826, 758, 702 30 (DMSO-d 6 ) ; 7.52-7.63 (m, 4H), 8.12 (s, 1H), 8.24-8.31 (m, 2H), 8.31 (s, 4H), 8.36 (s, 4H), 8.75 (d, 1H) 3376, 1600, 1523, 1374, 1316, 1083, 908, 829,767 31 (DMSO-d 6 ) ; 7.56 (m, 4H), 7.95 (d, 1H), 8.35 (m, 3H), 8.58(d, 1H) 3453, 1599, 1521, 1374, 1314, 1063, 824, 750, 699 32 (DMSO-d 6 ) ; 2.83 (s, 3H), 7.59 (m, 2H), 7.65 (m, 1H), 8.21 (s, 1H), 8.29 (m, 2H), 8.37 (s, 1H), 8.53 (m, 1H) 3386, 1579, 1522, 1452, 1375, 1320, 884, 767, 706 33 (DMSO-d 6 ); 3.91 (s, 3H), 7.40-7.58 (m, 4H), 8.01 (d, 1H), 8.19-8.27 (m, 3H), 8.35 (s, 1H), 3322, 1655, 1624, 1578, 1523, 1355, 8.30 (s, 4H) 1314, 1229, 831 34 (DMSO-d 6 ) ; 3.96 (s, 3H), 7.27 (d, 1H), 7.58 (m, 4H), 8.14 (s, 1H), 8.23 (d, 2H), 8.53 (d, 1H) 3370, 1619, 1518, 1376, 1315 35 (DMSO-d 6 ) ; 4.02 (s, 3H), 7.19 (d, 1H), 7.44-7.58 (m, 4H), 8.09 (d, 1H), 8.23-8.30 (m, 3H), 8.37 (s, 4H) 3380, 1662, 1608, 1526, 1364, 1316, 1262,754 36 (DMSO-d 6 ) ; 3.81 (s, 3H), 3.93 (s, 3H), 6.60 (s, 1H), 7.06 (s, 1H), 7.41 (m, 3H), 7.52 (s, 1H), 8.22 (d, 2H) 3373, 1620, 1599, 1518, 1371, 1314, 1254, 1209, 1167, 1141 37 (DMSO-d 6 ) ; 2.35 (s, 3H), 3.81 (s, 3H), 3.90 (s, 3H), 6.63 (d, 1H) 7.00 (d, 1H), 7.04(s, 1H), 7.33 (m, 4H) 3448, 1619, 1519, 1457, 1367, 1308, 1252, 1209, 1143 38 (DMSO-d 6 ) ; 3.98 (s, 3H), 4.04 (s, 3H), 7.46 -7.57 (m, 4H), 8.19-8.28 (m, 4H) 3855, 1637, 1508, 1375, 1250 39 (DMSO-d 6 ) ; 2.37 (s, 3H), 3.92 (s, 3H), 3.94 (s, 3H), 7.27-7.46 (m, 5H), 7.85 (s, 1H), 8.36 (s, 1H) 3442, 1654, 1508, 1357, 1249, 1162, 1043, 858, 764 40 (DMSO-d 6 ) ; 3.93 (s, 3H), 3.99 (s, 3H), 6.85 (d, 1H), 7.45-7.59 (3m, H), 7. 72 (d, 1H), 8.18 -8.23 (m, 2H), 8.28 (s, 1H) 3450, 1619, 1522, 1363, 1324, 1217, 1155, 768 41 (DMSO-d 6 ) ; 2.35 (s, 3H), 3.88 (s, 3H), 3.94 (s, 3H), 6.83 (d, 1H), 7.28-7.44 (m, 4H), 7.80 (d, 1H), 7.91 (s, 1H) 3422, 1619, 1523, 1457, 1374, 1216, 1155, 755 42 (DMSO-d 6 ) ; 2.35 (s, 3H), 3.19 (s, 3H), 3.90 (s, 3H), 6.92 (d, 1H), 7.11 (d, 1H), 7.25 (s, 1H), 7.37 (m, 4H), 8.37 (s, 4H) 3444, 1614, 1526, 1470, 1367, 1311, 1261, 1105, 761 43 (DMSO-d 6 ) ; 2.41 (s, 3H), 3.94(s, 3H), 3.98 (s, 3H), 7.34-7.36 (m, 3H), 7.48-7.54 (m, 2H) 7.73 (s, 1H), 8.45 (d, 1H) 3446, 1653, 1605, 1513, 1459, 1355, 1306,1268,1105, 740 44 (DMSO-d 6 ) ; 3.41 (s, 3H), 3.75 (t, 2H), 4.26 (t, 2H), 7.13 (d, 1H), 7.29-7.54 (m, 4H), 7.98 (d, 1H), 8.01-8.27 (m, 3H) 3448, 1655, 1606, 1534, 1458, 1372, 1318, 1262, 1100, 824, 756, 703 45 (DMSO-d 6 ) ; 2.37 (s, 3H), 3.44 (s, 3H), 5.38 (s, 2H), 7.30-7.63 (m, 6H), 7.76 (s, 1H), 8.31 (s, 4H), 8.70 (d, 1H) 3424, 1594, 1515, 1377, 1311, 1149, 1081, 1067, 992, 832, 770, 750, 661 46 (DMSO-d 6 ) ; 2.38(s, 3H), 7.18-7.50 (m, 6H), 7.67 (s, 1H), 8.53(d, 1H) 3383, 2975, 1622, 1522, 1457, 1387, 1231, 1090, 882, 746 47 (DMSO-d 6 ) ; 7.61 (m, 3H), 7.75 (t, 1H), 8.28 (m, 3H), 8.53(s, 1H), 8.97 (d, 1H) 3398, 1671, 1589, 1527, 1355, 1314, 765 48 (D 2 O) ; 6.88 (d, 1H), 7.27 (t, 1H), 7.55 (m, 3H), 7.63 (d, 1H), 8.17 (s, 1H), 8.31 (d, 2H) 3367, 1616, 1522, 1466, 1376, 1323, 766 49 (DMSO-d 6 ) ; 3.34 (s, 3H), 7.58 (m, 4H), 7.75 (d, 1H), 8.36 (m, 3H), 9.50(s, 1H) 3409, 1606, 1555, 1528, 1465, 1376, 1319, 1150 50 (DMSO-d 6 ) ; 2.34 (s, 3H), 7.60 (m, 4H), 8.23 (d, 1H), 8.32 (s, 1H), 8.40 (m, 2H), 8.59(d, 1H) 3340, 1670, 1586, 1531, 1374, 1324, 765, 693 51 (DMSO-d 6 ) ; 3.34 (s, 3H), 5.27 (s, 2H), 7.18 (t, 1H), 7.29 (d, 1H), 7.45 (t, 1H), 7.60(t, 1H), 7.73-7.81 (m, 2H), 8.08 (d, 1H), 8.20 (s, 1H), 8.70 (d, 1H) 3449, 1603, 1524, 1376, 1310, 990, 764 52 The HCl salt was measured. (DMSO-d 6 ) ; 7.03-7.09 (m, 2H), 7.44-7.50 (m , 1H), 7.77-7.82 (m, 1H), 7.93-7.99 (m, 1H), 8.21-8.33 (m, 3H), 8.74 (s, 1H) 3375, 2854, 1717, 1607, 1571, 1508, 1237, 768 Preparation Example 1 Oral agent containing 2-phenyl-8-methoxyquinoline-4-carbonylguanidine (Example 35) methanesulfonate as an active ingredient Ninety grams of the compound of the present invention were mixed with 40 g of lactose. The mixture was sieved through a No. 60 screen, and was wet-granulated with an alcohol solution containing 15 g of polyvinyl pyrrolidone. Then, 30 g of corn starch were added thereto, and these were mixed until uniform particles were formed. The mixture was passed through a No. 10 screen, placed on a tray, and dried in an oven of 60°C for 12 hours. The thus-dried particles were sieved through a No. 16 screen, and mixed with 3 g of magnesium stearate. The mixture was formed into tablets 7 mm in diameter by means of a tablet making machine through compression. The tablets were treated with varnish, and talc was spread. Then, moisture absorption was prevented, and an undercoat layer was coated around the cores. Varnish coating was conducted for internal use. In order to make the tablets completely smooth, an undercoat layer and a smooth coating were further applied thereto. The thus-coated tablets were dried, and then polished to form uniform glossy tablets. Preparation Example 2 Oral agent containing 2-(2'-methylphenyl)-5,7-dimethoxyquinoline-4-carbonylguanidine (Example 37) methanesulfonate as an active ingredient A tablet was prepared from 80 g of the compound of the present invention, 40 g of lactose, 13 g of polyvinyl pyrrolidone, 30 g of corn starch and 3 g of magnesium stearate in the same manner as in Preparation Example 1. Preparation Example 3 Injection containing 2-(2'-methylphenyl)-5,8-dimethoxyquinoline-4-carbonylguanidine (Example 42) methanesulfonate as an active ingredient The compound (0.5 g) of the present invention was taken up, and dissolved in 10 ml of a 0.9 % physiological saline solution. The mixture was sterilized through filtration, and poured into a 10-milliliter ampoule to form an injection. Preparation Example 4 Injection containing 2-phenyl-5,7-dimethoxyquinoline-4-carbonylguanidine (Example 36) hydrochloride as an active ingredient An injection was prepared from 0.3 g of the compound of the present invention and 10 ml of a 0.9 % physiological saline solution in the same manner as in Preparation Example 3. Test Example 1 : NHE inhibitory activity The NHE inhibitory activity was measured by the following method using a pH ir cells as an index. [Method of measuring a pH in cells] A rat mesenteric artery was isolated, and was loaded with a pH-sensitive dye BCECF. Subsequently, the tissue segments were mounted in a bath of an intracellular ion concentration measurement device (CAF-110, manufactured by Japan Spectral Co., Ltd.). The pH in cells was measured in terms of a ratio of fluorescent intensities through 2-wavelength excitation of 495 nm (pH-sensitive wavelength)/450 nm (pH-non-sensitive wavelength). [Measurement of the NHE activity] A pH in cells was shifted into an acid side through pretreatment with 20 mM ammonium chloride to activate NHE. At this time, when Na + ions were absent in an external solution, the intracellular acidosis was maintained. When Na + ions were present in an external solution, the pH in cells was recovered to a control value. This recovery of the pH in cells was ascribable to the activation of NHE. The NHE inhibitory activity of the medication was examined depending on whether or not this recovery was suppressed. The percent NHE inhibition was calculated from a change in pH (Δ pH) measured by the above-mentioned method using the following formula. Percent NHE inhibition (%) = {1 - Δ pH (in the presence of a medication) Δ pH (in the absence of a medication) } x 100 This test was conducted by the method of C. D. Foster et al. [Am. J. Physiol., 262 , 31, H1651 - H1655 (1992)]. For comparison, the test was conducted with respect to guanidinocarbonylisoquinoline derivatives described in JP A 6-211799 (Family: EP590455 ). The results of the measurements are shown in Table 2. Inhibitory effect on NHE activity Example No.: Test Compound Percent NHE inhibition (%) Conc. (µM) 0.1 1 2-(2'-methylphenyl)-4-guadininocarbonyl-1(2H)-isoquinoline hydrochloride (control compound) 1 2-phenylquinoline-4-carbonylguanidine hydrochloride 5.2 52.8 2 2-(4'-methylphenyl)quinoline-4-carbonylguanidine hydrochloride 10.6 41.4 3 2-(3'-methylphenyl)quinoline-4-carbonylguanidine hydrochloride 21.2 59.8 4 2-(2'-methylphenyl)quinoline-4-carbonylguanidine hydrochloride 49.2 65.6 5 2-(2'-isopropylphenyl)quinoline-4-carbonylguanidine methanesulfonate 29.3 42.3 6 2-(2',4'-dimethylphenyl)quinoline-4-carbonylguanidine methanesulfonate 36.4 55.3 7 2-(3',4'-dimethylphenyl)quinoline-4-carbonylguanidine methanesulfonate 33.1 38.8 8 2-(2',4',6'-trimethylphenyl)quinoline-4-carbonylguanidine methanesulfonate 23.7 36.3 11 2-(2'-trifluoromethylphenyl)quinoline-4-carbonylguanidine methanesulfonate 22.7 46.1 13 2-(4'-fluorophenyl)quinoline-4-carbonylguanidine hydrochloride 14.4 39.8 14 2-(2'-chlorophenyl)quinoline-4-carbonylguanidine methanesulfonate 28.8 34.3 19 2-(3'-nitrophenyl)quinoline-4-carbonylguanidine hydrochloride 22.3 35.6 20 2-(3'-aminophenyl)quinoline-4-carbonylguanidine hydrochloride 36.2 42.2 21 2-phenyl-3-methylquinoline-4-carbonylguanidine methanesulfonate 1.5 45.0 22 2-phenyl-6-methylquinoline-4-carbonylguanidine methanesulfonate 28.9 57.9 23 2-phenyl-7-methylquinoline-4-carbonylguanidine methanesulfonate 2.8 49.8 24 2-phenyl-8-methylquinoline-4-carbonylguanidine methanesulfonate 8.1 50.0 28 2-phenyl-5-chloroquinoline-4-carbonylguanidine methanesulfonate 33.7 63.3 29 2-phenyl-6-chloroquinoline-4-carbonylguanidine methanesulfonate 0 38.6 31 2-phenyl-8-chloroquinoline-4-carbonylguanidine methanesulfonate 12.0 57.0 32 2-phenyl-6-chloro-8-methylquinoline-4-carbonylguanidine hydrochloride 28.6 35.7 34 2-phenyl-7-methoxyquinoline-4-carbonylguanidine methanesulfonate 29.8 53.0 35 2-phenyl-8-methoxyquinoline-4-carbonylguanidine methanesulfonate 47.4 63.6 36 2-phenyl-5,7-dimethoxyquinoline-4-carbonylguanidine hydrochloride 53.2 69.9 37 2-(2'-methylphenyl)-5,7-dimethoxyquinoline-4-carbonylguanidine methanesulfonate 70.8 84.2 39 2-(2'-methylphenyl)-6,7-dimethoxyquinoline-4-carbonylguanidine methanesulfonate 3.4 41.5 40 2-phenyl-6,8-dimethoxyquinoline-4-carbonylguanidine methanesulfonate 18.3 31.0 42 2-(2'-methylphenyl)-5,8-dimethoxyquinoline-4-carbonylguanidine methanesulfonate 72.7 89.1 43 2-(2'-methylphenyl)-7,8-dimethoxyquinoline-4-carbonylguanidine methanesulfonate 28.0 37.6 44 2-phenyl-8-methoxyethyloxyquinoline-4-carbonylguanidine methanesulfonate 28.4 62.9 45 2-(2'-methylphenyl)-7-methoxymethyloxyquino-line-4-carbonylguanidine methanesulfonate 35.0 46.5 46 2-(2'-methylphenyl)-7-hydroxyquinoline-4-carbonylguanidine methanesulfonate 39.3 48.8 48 2-phenyl-8-aminoquinoline-4-carbonylguanidine methanesulfonate 30.6 41.7 49 2-phenyl-8-acetylaminoquinoline-4-carbonylguanidine methanesulfonate 20.8 51.2 50 2-phenyl-8-methanesulfonylaminoquinoline-4-carbonylguanidine methanesulfonate 46.2 66.2 Test Example 2 : Effect on ischemic arrhythmia in the rat A rat was anesthetized with pentobarbital, and the left chest was opened under artificial respiration. Then, the left coronary artery was ligated for 30 minutes. The effect of the test compound on ischemic arrhythmia was examined. The test agent was administered intravenously (i.v.) five minutes before the ligation. The arrhythmias were evaluated according to the guidelines of the Lambeth conventions [Cardiovasc. Res., 22 , 447 - 455 (1988)]. The test compounds, the number of examples and the number of rats in which the arrhythmia occurred are shown in Table 3. Effect on ischemic arrhythmia (i.v.) Example No.: Test Compound Number of examples Incidence of arrhythmia VT VF physiological saline (control) 11 5/5 4/5 36 2-phenyl-5,7-dimethoxyquinoline-4-carbonylguanidine hydrochloride (1 mg/kg) 4 2/4 0/4 37 2-(2'-methylphenyl)-5,7-dimethoxyquinoline-4-carbonylguanidine methanesulfonate (1 mg/kg) 5 3/5 0/5 42 2-(2'-methylphenyl)-5,8-dimethoxyquinoline-4-carbonylguanidine methanesulfonate (1 mg/kg) 4 2/4 0/4 VT: ventricular tachycardia VF: ventricular fibrillation Test Example 3 : Toxicity test The test compound was administered to a ddy-strain male mouse, and the toxicity was examined. The test compound was administered intravenously (i.v.) in a dose of 100 mg/kg, and the toxicity was evaluated in terms of mortality of mice after 24 hours of the administration (number of specimens: one group consisting of 3 mice). The results are shown in Table 4. Result of toxicity test Example No.: Test Compound Mortality (%) 100 mg/kg (i.v.) 42 2-(2'-methylphenyl)-5,8-dimethoxyquinoline-4-carbonylguanidine methanesulfonate 0 Effects of the invention As mentioned above, the compounds of the present invention have a strong inhibitory effect on NHE activity, and these compounds are quite useful as an agent for preventing or treating diseases caused by enhanced NHE activity, such as hypertension, arrhythmia, myocardial infarction, angina pectoris, arteriosclerosis, diabetic complication, cancers, fibrosis, cardiac hypertrophy or prostatic hypertrophy. Further, these compounds are useful as an ingredient of a protective solution of internal organs cut from the body for transplantation or internal organs transplanted and as a diagnostic agent for diseases in which NHE activity is enhanced.

Claims: A quinoline-4-carbonylguanidine derivative represented by formula (1) wherein R 1 , R 2 , R 3 and R 4 are the same or different and each represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a halogen atom, a nitro group, an amino group, a hydroxyl group, an alkyloxy group having from 1 to 6 carbon atoms, an alkyloxy group having from 1 to 6 carbon atoms and containing a terminal alkyloxy group having from 1 to 6 carbon atoms, an alkylsulfonylamino group having from 1 to 6 carbon atoms, or an alkanoylamino group having from 2 to 6 carbon atoms, X 1 , X 2 , X 3 , X 4 and X 5 are the same or different and each represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a halogen atom, a nitro group, an amino group, a hydroxyl group, a trifluoromethyl group, an alkyloxy group having from 1 to 6 carbon atoms, an alkyloxy group having from 1 to 6 carbon atoms and containing a terminal alkyloxy group having from 1 to 6 carbon atoms, or a trifluoromethoxy group, and Y represents a hydrogen atom, or an alkyl group having from 1 to 6 carbon atoms, or a pharmaceutically acceptable salt thereof. The quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in claim 1, wherein one or two of R 1 , R 2 , R 3 and R 4 represent an alkyloxy group having from 1 to 6 carbon atoms. The quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in claim 1, wherein X 1 represents a methyl group. The quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in claim 2, wherein X 1 represents a methyl group. A process for producing the quinoline-4-carbonylguanidine derivative of claim 1, 2, 3 or 4, which comprises reacting a quinoline-4-carboxylic acid derivative represented by formula (2) wherein L represents a hydroxyl group, or a leaving group that can easily be substituted by means of a nucleophilic reagent, and R 1 , R 2 , R 3 , R 4 , X 1 , X 2 , X 3 , X 4 , X 5 and Y are as defined in formula (1) with guanidine. A pharmaceutical composition containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in claim 1, 2, 3 or 4. A Na + /H + exchanger inhibitor containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in claim 1, 2, 3 or 4. An agent for treating or preventing hypertension, said agent containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in claim 1, 2, 3 or 4. An agent for treating or preventing arrhythmia, said agent containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in claim 1, 2, 3 or 4. An agent for treating or preventing angina pectoris, reperfusion arrhythmia and myocardial infarction caused by ischemia, ischemic arrhythmia, organ disorders caused by ischemia and reperfusion, cerebral ischemic disorders, cerebral apoplexy and ischemic diseases of limbs and peripheral organs, said agent containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in claim 1, 2, 3 or 4. An agent for treating or preventing diseases caused by cell proliferation or hypertrophy, said agent containing as an active ingredient the quinoline-4-carbonyl-guanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in claim 1, 2, 3 or 4. An agent for treating or preventing organ disorders caused by ischemia in surgical operation or transplantation of internal organs, said agent containing as an active ingredient thequinoline-4-carbonylguanidinederivative or the pharmaceutically acceptable salt thereof as mentioned in claim 1, 2, 3 or 4. An agent for treating or preventing diseases caused by infiltration of leukocytes, said agent containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in claim 1, 2, 3 or 4. A protective solution of internal organs cut from the body for transplantation or internal organs transplanted, said protective solution containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in claim 1, 2, 3 or 4. An agent for diagnosis of hypertension, diseases caused by cell growth and diabetes through inhibition of a Na + /H + exchanger, said agent containing as an active ingredient the quinoline-4-carbonylguanidine derivative or the pharmaceutically acceptable salt thereof as mentioned in claim 1, 2, 3 or 4.

Inventors: BANNO HITOSHI, FUJIWARA JUNYA, HOSOYA JUNKO, KITAMORI TAKASHI, MORI HARUKI, YAMASHITA HIROYUKI, BANNO, HITOSHI, FUJIWARA, JUNYA, HOSOYA, JUNKO, KITAMORI, TAKASHI, MORI, HARUKI, YAMASHITA, HIROYUKI
Applicants: MITSUI TOATSU CHEMICALS, MITSUI TOATSU CHEMICALS, INC.
Application year: 1996
Main classification: C07D215
IPC codes: C07D215