NOVEL SULFAMATE COMPOUND CONTAINING N-SUBSTITUTED CARBAMOYL GROUP AND METHOD FOR PREPARING THE SAME

Abstract: There are disclosed novel sulfamate compounds containing N-substituted carbamoyl group including their racemates and (R)- and (S)-optical isomers represented by Formulas (I), (II) and (III), pharmaceutically useful for the prophylaxis and treatment of the disorders of the central nervous system, especially for nervous myalgia, epilepsy and minimal brain dysfunction. In said formulas, Ar is represented by formulas (a), (b), (c), (d), (e), Y is selected from the group consisting of halogens such as F, Cl, Br and I, trifluoromethyl and alkyl groups containing 1 to 3 carbon atoms when Y alone binds to benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 to 3 carbon atoms when Y binds to X which is O or S; and R1, R2, R3 and R4, identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 to 16 carbon atoms, cyclic alkyl groups containing 3 to 16 carbon atoms and aryl groups containing 6 to 8 carbon atoms, and NR1R2 and NR3R4, identical or different, each may form a 3- to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom.

Description: NOVEL SULFAMATE COMPOUND CONTAINING N-SUBSTITUTED CARBAMOYL GROUP AND METHOD FOR PREPARING THE SAME BACKGROUND OF THE INVENTION Field of the invention The present invention relates to pharmaceutically useful sulfamate compounds containing N-substituted carbamoyl group and, more particularly, to N,N'-substituted carbamoyl-2-aryl propanol sulfamates including their racemates and (R ) - and (S ) -optical isomers, useful for the prophylaxis and treatment of the disorders of the central nervous system. Also, the present invention is concerned with methods for preparing the same. Description of the Prior Art Sulfamate compounds are well known to be useful as medicines for controlling various central nervous system (CNS) disorders, especially as antiepileptic. As a prior art relating to these compounds, fructopyranose sulfamate compounds are reported in J. Med. Chem. 30, 880- 887(1987 ) , together with their pharmaceutical effects. Other pharmaceutically useful sulfamates are also known. For example, sorbopyranose sulfamates and penethylsulfamfite are disclosed in PCT WO 14827 and U S. Pat. No. 4,792,569, respectively. These compounds have effectively been used as therapeutical medicines for managing CNS diseases, such as an antiepileptic. Active research and development efforts have been and continue to be directed to the application of sulfamate compounds for CNS disorders. SUMMARY OF THE INVENTION As a result of intensive and thorough research for the sulfamate derivatives of 2-aryl-l,3-propanediol, the present inventors found that the compounds introduced with N-substituted carbamoyl group are pharmaceutically useful in prophylaxis and treatment of CNS disorders. Accordingly, it is an objective of the present invention to provide novel N-substituted carbamoyl -containing sulfamate compounds effective for the prophylaxis and treatment of CNS disorders. These sulfamate compounds comprise racemates represented by the following Formula I and their (R)- and (S)-optical isomers represented by the following Formulas II and III, respectively: (I ) dl ) (III) wherein, Ar is represented by the following formulas; Y is selected from the group consisting of halogens such as F, Cl, Br and 1, trifluoromethyl and alkyl groups containing 1 to 3 carbon atoms when Y alone binds to benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 to 3 carbon atoms when Y binds to X which is 0 or S; and Ri, R2, R and R 1. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 to 16 carbon atoms, cyclic alkyl groups containing 3 lo 16 carbon atoms and aryl groups containing 6 to 8 carbon atoms, and NR1R2 and NR3R-1, identical or different, each may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom. Because the N,N '-substituted carbamoyl 2-aryl propanol sulfamate represented by Formula I has a chiral center at the benzyl position, they may be in either (R)- or (S)-optical isomer. In vivo, an optical isomer of one compound may exhibit even better pharmaceutical effect than other optical isomers, and many examples of the optical effect have been reported. Recent trend is to use optical isomers to develop new medicines. Thus, it is very important to separate the racemic mixture of one compound into respective optical isomers and apply them for pharmacology. Based upon this fact, the present inventors found that their (R ) - and (S ) -optical isomers are very effective for the prophylaxis and treatment of the disorders of the central nervous system, especially as antiepileptic, acute ischemic stroke and neuroprotective. It is another objective of the present invention to provide methods for preparing the N,N' -substituted carbamoyl-2-aryl propanol sulfamate racemates and their pure (R)- and (S)-optical isomers. It is a further objective of the present invention to provide the intermediates useful for producing the N,N-substituted carbamoyl-2-aryl propanol sulfamate racemates represented by Formula I, including 3-N-substituted carbamoyl-2-aryl propanol acetate represented by the following formula IV: (IV) wherein Ar, Ri and R.> are as defined above, 3-N-substituted carbamoyl-2-aryl propanol represented by the following formula V: (V) wherein Ar. Rι and R> are as defined above, 3-acetoxy-2- aryl propanol sulfamate represented by the following formula VL (VI) wherein Ar, R:s and Ri are as defined above, 2-aryl-l,3-propandiol monosulfamate represented by the following formula VII: A (VII) wherein Ar, R:ι, and Ri are as defined above; the intermediates useful for producing the (R)-N,N'-substituted carbamoyl-2-aryl propanol sulfamate represented by Formula II including (S ) -3-N-substituted carbamoyl-2-aryl propanol acetate represented the following formula VIII: (VIII) wherein Ar, Ri and R; are as defined above with the proviso that Ri and R> are not hydrogen atoms simultaneously, and (S ) -3-N-substituted carbamoyl-2-aryl propanol represented by the following formula IX: (IX) wherein Ar, Ri and R2 are as defined above with the proviso that Ri and R- are not hydrogen atoms simultaneously: and the intermediates useful for producing the (S)-N.N'-substituted carbamoyl-2-aryl-propanol sulfamate represented by Formula III including the (S)-3-acetoxy-2-aryl-l,3-propandiol sulfamate represented by the following formula X: R 3 R 4 (X ) wherein Ar, R:; and Ri are as defined above, the (S)-2-aryl-l,3-propandiol monosulfamate represented by the following formula XL (XI ) wherein Ar, R:;, and R.i are as defined above, (R)-3-N- substituted carbamoyl-2-aryl propanol acetate represented by the following formula XIL (XII) wherein Ar, Ri and R> are as defined above with the proviso that Ri and R> are not hydrogen atoms simultaneously, and (R ) -3-N-substituted carbamoyl-2-aryl propanol represented by the following structural formula XIIL R 2 (XIII) wherein Ar, Ri and R> are as defined above with the proviso that Ri and R:; are not hydrogen atoms simultaneously. For accomplishing the above objectives, there are provided the N,N' -substituted carbamoyl-2-aryl propanol sulfamate racemates represented by the following formula L (I ) wherein Ar is represented by the following formulas; Y is selected from the group consisting of halogens such as F, Cl, Br and I, trifluoromethyl and alkyl groups containing 1 to 3 carbon atoms when Y alone binds to benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 to 3 carbon atoms when Y binds to X which is O or S; and Ri, R2, a and R 1. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 to 16 carbon atoms, cyclic alkyl groups containing 3 to 16 carbon atoms and aryl groups containing 6 to 8 carbon atoms, and NR1R2 and NR3R-1, identical or different, each may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen ιtom. The N, N-substituted carbamoyl-2-aryl propanol sulfamate compounds represented by Formula I can be prepared by the following three methods, in accordance with the present invention. A detailed description will be given of a first method below, in conjunction with reaction schemes. First, the 3-acetoxy-2-aryl propanol of Formula XIV is reacted with carbonyl diimidazole in dichloromethane solution to give the 3-imidazolyl carbonyloxy-2-aryl propanol acetate of Formula XV, which is, without purification, reacted with the substituted amine of Formula XVI to produce the 3-N-substituted carbamoyl-2-aryl propanol acetate of Formula IV, as shown in Reaction Scheme L Reaction Scheme I wherein Ar, Ri and R ^ each are as defined above. Detailed conditions for the above reactions are as follows; The compound of Formula XIV, the starting material, is reacted preferably at an amount of about 0.1 to 2.0 moles with 1.1 to 2.5 equivalents of carbonyl diimidazole when considering yield and economical aspects. It is preferable that the former reaction of Reaction Scheme I is carried out at a temperature of -5 to 40TY For example, if the reaction is performed at a temperature less than -5TY the progress of the reaction is very slow. On the other hand, if it is carried out at a temperature higher than 40 'C , the yield decreases due to side reactions. Useful solvents in this reaction include low hydrocarbon halide solvents, such as methylene chloride and chloroform, ethereal solvents, such as ethyl ether and tetrahydrofuran, and acetonitrile with preference lo methylene chloride, chloroform and tetrahydrofuran. In the preparation reaction of the compound of Formula IV from the compound of Formula XV, the substituted amine is used at an amount of 1.0 to 5.0 equivalents, in consideration of rapid reaction and after-treatment. This reaction is executed at a temperature ranging from 0 to 30 "C in a solvent selected from tetrahydrofuran and methylene chloride. Next, the 3-N-substituted carbamoyl-2-aryl propanol acetate of Formula IV is subjected to transesterification in an alcohol solvent in the presence of a base catalyst, to give the 3-N-substituted carbamoyl-2-aryl propanol of the following formula V. as shown in Reaction Scheme IL Reaction Scheme II (IV) (V) wherein Ar, Ri and R> each are as defined above. In the transesterification, the 3-N -substituted carbamoyl -2-aryl propanol acetate of Formula IV is used at an amount of 0.1 to 2.0 moles. As the base catalyst, sodium hydroxide, potassium hydroxide, sodium carbonate, lithium hydroxide, potassium carbonate, sodium bicarbonate or potassium cyanide is used at an amount of 0.1 to 1.0 equivalent at a temperature of 0 to 30 * C . Useful solvents include methylalcohol, ethylalcohol and propylalcohol. Preferred is methylalcohol when considering the reaction yield and the removal convenience after completion of the reaction. Attention must be paid to the point that the base catalyst remained in the reaction mixture is required to be inactivated after the reaction. If the active base catalyst is remained, a reverse reaction occurs during after-treatment, returning the product into the starting material. For the inactivation of the base catalyst, a proper acidic material is added to the reaction mixture after the reaction has been completed. Preferred is IN hydrochloric acid solution or saturated ammonium chloride solution. In subsequence, the compound of Formula V is reacted with sulfamoyl chloride in the presence of a base catalyst, to prepare the N.N '-substituted carbamoyl-2-aryl propanol sulfamate. This reaction is depicted in Reaction Scheme IIL Reaction Scheme III (V) (I) wherein Ar, Rt, R:>, Ra and R.i are as defined above. The 3-N -substituted carbamoyl-2-aryl propanol represented by Formula V is used at an amount of 0.1 to 2.0 moles. As the base catalyst, triethylamine, pyridine, antipyrin, or diisopropylethylamine is employed. Available reaction solvents include amide solvents, such as dimethylformamide, ethereal solvents, such as ethyl ether and tetrahydrofuran, and acetonitrile with preference to tetrahydrofuran and acetonitrile. It is preferable that this reaction is carried out at a temperature of -10 to 40'C. For example, if the reaction temperature is maintained below -10 , , the progress of the reaction is very slow. On the other hand, if the reaction is carried out at a temperature higher than 40'C , the yield lowers by the production of unknown by-products. When considering reaction progress, convenience in after-treatment and economical aspects, it is preferable that the base catalyst and the sulfamoyl chloride are used at an amount ranging from 2.0 to 4.0 equivalents and from 1.5 to 3.0 equivalents, respectively. Following is a second method for preparing the compound of Formula I. Initially, the 3-aceloxy-2-aryl propanol represented by Formula XIV is reacted with sulfamoyl chloride in an acetonitrile solvent in the presence of a base catalyst, to give the 3-acetoxy-2-aryl propanol sulfamate of Formula VI, as shown in Reaction Scheme IV: Reaction Scheme IV (XIV) (VI) wherein Ar, RΛ- and R.i each are as defined above. The 3-acetoxy-2-aryl propanol of Formula XIV is used at an amount of 0.1 to 2.0 moles. As the base catalyst, triethylamine, pyridine, antipyrin, or diisopropylethylamine is employed. Available reaction solvents include amide solvents, such as dimethylformamide, ethereal solvents, such as ethyl ether and tetrahydrofuran, and acetonitrile. Of them tetrahydrofuran and acetonitrile are preferred by virtue of their being easily removed after the reaction. It is preferable that this reaction is carried out at a temperature of -10 to 40'C. For example, if the reaction is executed al too low temperature, the reaction is very slow. On the other hand, if the reaction is carried out at a temperature higher than 40XY the yield lowers by the production of unknown by-products. When considering reaction progress, convenience in after-treatment and economical aspects, it is preferable that the base catalyst and the sulfamoyl chloride are used at an amount ranging from 2.0 to 4.0 equivalents and from 1.5 to 3.0 equivalents, respectively. Thereafter, using a base catalyst, the 3-aceloxy-2-aryl propanol sulfamate represented by Formula VI is subjected ιr to transesterification in an alcohol solvent, to give the 2-aryl-l,3-propandiol monosulfamate of Formula VII, as depicted in Reaction Scheme V: Reaction Scheme V (VI) (VII) wherein Ar, R.i and Ri each are as defined above. In such transesterification, the 3-acetoxy-2-aryl propanol sulfamate of Formula VI is used at an amount of 0.1 to 2.0 moles. As the base catalyst, sodium hydroxide, potassium hydroxide, lithium hydroxide, sodium carbonate, sodium bicabonate, potassium carbonate, or potassium cyanide is used at an amount of 0.1 to 1.0 equivalent at a temperature of 0 to 30 "C . Useful solvents include methylalcohol, ethylalcohol and propylalcohol. Preferred is methylalcohol when considering the reaction yield and the removal convenience after completion of the reaction. As the first method, the base catalyst remained in the reaction mixture is required to be inactivated after completion of the transesterification. For this, IN hydrochloric acid solution or saturated ammonium chloride solution is preferably used. In a subsequent procedure, the 2-aryl-l,3-propandiol monosulfamate of Formula VII obtained is reacted with carbonyldiimidaxol in dichloromethane solvent to give the 3-imidazolyl carbonyloxy-2-arylpropanol sulfamate represented by formula XVII, which is, without purification, reacted with the substituted amine of Formula XVI to prepare the N,N '-substituted carbamoyl-2-aryl propanol sulfamate compounds of Formula 1, the objective compound, as depicted in Reaction Scheme VL. Reaction Scheme VI (I) wherein Ar, Ri, R>, R:ι and Ri each are as defined above. About 0.1 to 2.0 moles of the compound of Formula VII is preferably reacted with 1.1 to 2.5 equivalents of carbonyl diimidazole when considering yield and economical aspects. It is preferable that the former reaction of Reaction Scheme VI is carried out at a temperature of -5 to 40"C . For example, if the reaction is performed at a temperature less than -5"C, the reaction is very slow. On the other hand, if it is carried out at a temperature higher than 40 ' C, the yield decreases due to side reactions. Useful solvents for this reaction include low hydrocarbon halide solvents, such as methylene chloride and chloroform, ethereal solvents, such as ethyl ether and tetrahydrofuran, and acetonitrile with preference to methylene chloride, chloroform and tetrahydrofuran. In the reaction of preparing the compound of Formula I from the compound of Formula XVII, the substituted amine is used at an amount of 1.0 to 5.0 equivalents at a temperature ranging from 0 to 30 ' C in a solvent selected from tetrahydrofuran and methylene chloride. In a third method for preparing the compound of Formula I, the 2-aryl-l,3-propandiol monosulfamate of Formula VII is reacted with isocyanate represented by Formula XVIII in a hydrocarbon halide or ethereal hydrocarbon solvent, to prepare the N,N' -substituted carbamoyl-2-aryl-l,3-propandiol sulfamate compound of Formula I, as shown in Reaction Scheme VIL Reaction Scheme VII (vπ) (i) wherein Ar, Ri, R.i and Ri each are as defined above. As shown in Reaction Scheme VII, the 2-aryl-l,3 -propandiol monosulfamate of Formula VII, the starting material, is reacted preferably at an amount of about 0.1 to 2.0 moles with 1.0 to 2.0 equivalents of isocyanate when considering reaction progress and economical aspects. It is preferable that this reaction is carried out at a temperature of 0 to 80 TY For example, if the reaction is performed at a temperature less than O ' , the reaction is not accomplished. On the other hand, if it is carried out at a temperature higher than 80 "C, too much by-products are produced by the reaction of isocyanate itself. Useful solvents for this reaction include low hydrocarbon halide solvents, such as methylene chloride and chloroform, ethereal solvents, such as ethyl ether and tetrahydrofuran, and aromatic hydrocarbon solvents, such as benzene and toluene with preference lo methylene chloride, chloroform, benzene and toluene. In accordance with the present invention, the compound of Formula II is prepared by following pathway described below. This preparation starts with (R)-3-acetoxy-2-aryl propanol as shown in Reaction Scheme VIIL Ii ) Reaction Scheme VIII HNR j R 2 (XVI) wherein Ar, Ri and R each are as defined above. (R)-3-acetoxy-2-aryl propanol of Formula XIX is reacted with carbonyl diimidazole in dichloromethane solvent, to give (S)-3-imidazolyl carbonyloxy-2-aryl propanol acetate which is, without purification, reacted with the substituted amine of Formula XVI, to produce the (S)-3-N-substituted carbamoyl-2-aryl propanol acetate of Formula VIII. The compound of Formula XIX, the starting material, is reacted preferably at an amount of about 0.1 to 2.0 moles with 1.1 to 2.5 equivalents of carbonyl diimidazole when considering yield and economical aspects. It is preferable that the former reaction of Reaction Scheme VIII is carried out at a temperature of -5 to 40'C. For example, if the reaction temperature is below -5 ° C, the reaction is very slow. On the other hand, if the former reaction is carried out at a temperature higher than 40'C, the yield decreases by side reactions. Useful solvents for this reaction include low hydrocarbon halide solvents, such as methylene chloride and chloroform, ethereal solvents, such as ethyl ether and tetrahydrofuran, and acetonitrile with preference lo methylene chloride, chloroform and tetrahydrofuran. For the preparation reaction of the compound of Formula VIII from the compound of Formula XX, the substituted amine is used at an amount of 1.0 to 5.0 equivalents. This reaction is executed at a temperature ranging from 0 to 30 "C in a solvent such as tetrahydrofuran and methylene chloride. Then, the (S ) -3-N-substituted carbamoyl-2-aryl propanol acetate of Formula VIII is subjected to transesterification to prepare (S)-3-N -substituted carbamoyl-2-aryl propanol of Formula IX in an alcohol solvent in the presence of a base catalyst, as shown in Reaction Scheme IX: Reaction Scheme IX (VIII) (IX) wherein Ar, Ri and R2 each are as defined above. In the transesterification, the (S ) -3-N-substiluted carbamoyl-2-aryl propanol acetate of Formula VIII is used at an amount of 0.1 to 2.0 moles. As the base catalyst, sodium hydroxide, potassium hydroxide, lithium hydroxide, potassium carbonate, or potassium cyanide is used al an amount of 0.1 to 1.0 equivalent at a temperature of 0 lo 30 "C . Useful solvents include methylalcohol, ethylalcohol and propylalcohol. Preferred is methylalcohol when considering the reaction yield and the removal convenience after completion of the reaction. Also, as mentioned in the first and the second methods for the preparation of the compounds of Formula I, it is needed that the base catalyst remained in the reaction mixture should be inactivated after the reaction. For this, IN hydrochloric acid solution or saturated ammonium chloride solution is preferred. In subsequence, the (S )-3-N -substituted carbamoyl- 2-aryl propanol of Formula IX is reacted with sulfamoyl chloride in the presence of a base catalyst, to prepare the N,N' -substituted carbamoyl-2-aryl propanol sulfamate of Formula II. This reaction is depicted in Reaction Scheme X: Reaction Scheme X C1SO NR 3 R (IX) (II) wherein Ar, Ri, R >, Ru, and Ri are as defined above. The (S)-3-N -substituted carbamoyl-2-aryl propanol represented by Formula IX is used at an amount of 0.1 to 2.0 moles while the sulfamoyl chloride at an amount of about 1.0 to 3.0 equivalents. As the base catalyst, triethylamine, pyridine, antipyrin, or diisopropylethylamine is employed. When considering reaction progress, convenience in after-treatment and economical aspects, it is preferable that the base catalyst is used at an amount ranging from 2.0 to 4.0 equivalents. Available reaction solvents include amide solvents, such as dimethylformamide, ethereal solvents, such as ethyl ether and tetrahydrofuran, and acetonitrile with preference to tetrahydrofuran and acetonitrile. It is preferable that this reaction is carried out at a temperature of -10 lo 40'C. For example, if the reaction temperature is maintained below -10"C, the reaction is significantly slow. On the other hand, if the reaction is carried out at a temperature higher than 40TY the yield decreases by the production of unknown by-products. There are two pathways for preparing the compound of Formula III, in accordance with the present invention. In a first pathway, an (R ) -3-acetoxy-2-aryl propanol of Formula (XIX) is used as the starting material, as shown in Reaction Scheme XL Reaction Scheme XI (XIX) (X) wherein Ar, RΛ and Ri each are as defined above. The (R)-3-aceloxy-2-aryl propanol of Formula XIX is reacted with sulfamoyl chloride in an acetonitrile solvent in the presence of a base catalyst, to give an (S)-3-aceloxy- 2-aryl-l,3-propandiol sulfamate of Formula X. The (R)-3-aceloxy-2-aryl propanol of Formula XIX is used at an amount of 0.1 to 2.0 moles. As the base catalyst, triethylamine, pyridine, antipyrin, or diisopropylelhvl amine is employed. When considering reaction progress, convenience in after-lreatmenl and economical aspects, il is preferable that the base catalyst is used at an amount ranging from 2.0 to 4.0 equivalents. Available reaction solvents include amide solvents, such as dimethylformamide, ethereal solvents, such as ethyl ether and tetrahydrofuran, and acetonitrile. Of them tetrahydrofuran and acetonitrile are preferred. It is preferable that this reaction is carried out at a temperature of -10 to 40'C. For example, if the reaction is executed at too low lemperature, the reaction is very slow. On the other hand, if the reaction is carried out at a temperature higher than 40'C, the yield decreases by the production of unknown by-products. Thereafter, using a base catalyst, the (S ) -3-acetoxy-2- aryl-l,3-propandiol sulfamate of Formula X is subjected to transesterification in an alcohol solvent, to give the (S ) -2- aryl-l,3-propandiol monosulfamate of Formula XI, as depicted in Reaction Scheme XVL Reaction Scheme XVI (X) (XI) wherein Ar, R:ι and Ri each are as defined above. In this transesterification, the (S) ~ 3-acetoxy-2-aryl- 1 ,3- propandiol sulfamate of Formula X is used at an amount of about 0.1 to 2.0 moles. As the base catalyst, sodium hydroxide, potassium hydroxide, lithium hydroxide, potassium carbonate, or potassium cyanide is used at an amount of 0.1 to 1.0 equivalent al a temperature of 0 to 30'C. Useful solvents include methylalcohol, ethylalcohol and propylalcohol. Preferred is methylalcohol when considering the reaction yield and the removal convenience after completion of the reaction. As in the first method for the preparation of the compound of Formula I, the base catalyst remained in the reaction mixture is required to be inactivated after completion of the transesterification. For this, IN hydrochloric acid solution or saturated ammonium chloride solution is preferably used. There is a subsequent procedure in Reaction Scheme XIIL ?π Reaction Scheme XIII H RjR 2 (XVI) wherein Ar, Ri, R:>, RΛ and R.i each are as defined above. In Reaction Scheme XIII, the (S)-2-aryl~l,3-propandiol monosulfamate of Formula XI is reacted with carbonyl diimidazole in dichloromethane solvent to give the (S)-3-imidazolyl carbonyloxy-2-arylpropanol sulfamate which is, without purification, with the substituted amine of Formula XVI, to prepare the N.N'- substituted carbamoyl-2-aryl propanol sulfamate of Formula III, the objective compound. About 0.1 lo 2.0 moles of the compound of Formula XI is preferably reacted with 1.1 to 2.5 equivalents of carbonyl diimidazole when considering yield and economical aspects. It is preferable thai the former reaction of Reaction Scheme XIII is carried out at a temperature of -5 to 40 ' C . For example, if the reaction is performed at a temperature less than -5'C , the reaction is very slow. On the other hand, if it is carried out at a temperature higher than 40"C, the yield decreases by side reactions. Useful solvents for this reaction include low hydrocarbon halide solvents, such as methylene chloride and chloroform, ethereal solvents, such as ethyl ether and tetrahydrofuran, and acetonitrile with preference to methylene chloride, chloroform and tetrahydrofuran. In the preparation reaction of the compound of Formula III from the compound of Formula XXI, the substituted amine is used at an amount of 1.0 to 5.0 equivalents at a temperature ranging from 0 to 30'C in a solvent such as tetrahydrofuran and methylene chloride. Alternatively, the compound of Formula III can be prepared by using (S ) -3-acetoxy-2-aryl propanol of Formula XXII as the starting material, in accordance with the present invention, as shown in Reaction Scheme XIV: Reaction Scheme XIV HNR^ (XVI) wherein Ar, Ri and R2 each are as defined above. The (S)-3-acetoxy-2-aryl propanol of Formula XXII is reacted with carbonyl diimidazole in dichloromethane solution to give the (R ) -3-imidazolyl carbonyloxy-2-aryl propanol acetate of Formula XXIII, which is, without purification, reacted with the substituted amine of Formula XVI, to produce the (R ) -3-N-substituled carbamoyl-2-aryl propanol acetate of Formula XII. The compound of Formula XXII is reacted preferably al an amount of about 0.1 to 2.0 moles with 1.1 to 2.5 equivalents of carbonyl diimidazole when considering yield and economical aspects. It is preferable that the former reaction of Reaction Scheme XIV is carried out at a temperature of -5 to 40'C. For example, if the reaction is performed at a temperature less than -5"C , the reaction is very slow. On the other hand, if it is carried out at a temperature higher than 40'(Y the yield decreases by side reactions. Useful solvents in this reaction include low hydrocarbon halide solvents, such as methylene chloride and chloroform, ethereal solvents, such as ethyl ether and tetrahydrofuran, and acetonitrile with preference to methylene chloride, chloroform and tetrahydrofuran. The preparation reaction of the compound of Formula XII from the compound of Formula XXIII is carried out with 1.0 to 5.0 equivalents of the substituted amine at a temperature ranging from 0 to 30 ' C in a solvent such as tetrahvdrofuran and melhvlene chloride. There is a subsequent procedure in Reaction Scheme XV: Reaction Scheme XV wherein Ar, Ri and R> each are as defined above. The (R ) -3-N -substituted carbamoyl-2-aryl propanol acetate of Formula XII is subjected to transesterification to obtain the (R)-3-N -substituted carbamoyl-2-aryI propanol of Formula XIII. This reaction is executed in an alcohol solvent in the presence of a base catalyst. In the transesierificalion, the (R)-3-N-substitυted carbamoyl-2-aryl propanol acetate of Formula XII is used at an amount of 0.1 to 2.0 moles. As the base catalyst, sodium hydroxide, potassium hydroxide, lithium hydroxide, potassium carbonate, or potassium cyanide is used at an amount of 0.1 to 1.0 equivalent at a temperature of 0 to 30 * C . Useful solvents include methylalcohol, ethylalcohol and propylalcohol. Preferred is methylalcohol when considering the reaction yield and the removal convenience after completion of the reaction. As in the first and the second methods for the preparation of the compound of Formula 1, it is needed to inactivate the used base catalyst after the transesterification. For the inactivation of the base catalyst. IN hydrochloric acid solution or saturated ammonium chloride solution is preferably used. Next, the (R)-3-N-substituted carbamoyl-2-aryl propanol of Formula XIII is reacted with sulfamoyl chloride in the presence of a base catalyst, to prepare the objective compound of Formula III. This reaction is depicted in Reaction Scheme XVL Reaction Scheme XVI wherein Ar, Ri, R>, R.i, and R 4 each are as defined above. The (R)-3-N -substituted carbamoyl-2-aryl propanol represented by Formula XIII is used at an amount of 0.1 lo 2.0 moles while sulfamoyl chloride at an amount of about 1.0 to 3.0 equivalents. As the base catalyst, triethylamine, pyridine, antipyrin, or diisopropylethylamine is employed. When considering reaction progress. convenience in after-treatment and economical aspects, it is preferable that the base catalyst is used at an amount ranging from 2.0 to 4.0 equivalents. Available reaction solvents include amide solvents, such as dimethylformamide, ethereal solvents, such as ethyl ether and tetrahydrofuran, and acetonitrile with preference to tetrahydrofuran and acetonitrile. It is preferable that this reaction is carried out at a temperature of -10 to 40 ° C . For example, if the reaction temperature is maintained below -10 " , the reaction is very slow. On the other hand, if the reaction is carried out at a temperature higher than 40 ' C, the yield decreases by the production of unknown by-products. A better understanding of the present invention may be obtained in light of following examples which are set forth toillustrate, but are not to be construed to limit, the present invention. EXAMPLE 1 Preparation of 3-Carbamoyl-2-phenyl propanol acetate A well dried 1,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 400 ml of purified methylene chloride was poured into the flask. 50 g of 3-acetoxy-2-phenyI propanol was well dissolved in the solvent and made to be homogeneous by stirring for 5 min. While being maintained at 0 ° C , the homogeneous solution was slowly added with 49.8 g of carbonyl diimidazole. After the starting material completely disappeared as measured by thin layer chromatography, 43.8 ml of aqueous ammonia was slowly added to the reaction solution in order to progress the reaction. To determine when the reaction would be terminated. the reaction was under double monitoring of thin layer chromatography and liquid chromatography. Roughly, it took about 1 hour to finish the reaction. After completion of reaction, 400 ml of distilled water was added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. This concentrated liquid mixture was separated by column chromatography using a mixture of ethyl acetate/n-hexane (2:1) as a mobile phase, to obtain 58.0 g of 3-carbamoyl-2-phenyl propanol acetate as a white solid. Yield 95% H-NMR(CDC 200 MHz ) , ppm ( δ ): 1.98(3H.s). 3.28(lH,q).4.28(4II.d ) , 5.21 (2H.br), 7.27(5H,m) EXAMPLE 2 Preparation of 3-N-melhylcarbamoyl-2-phenyl propanol acetate Except for using methylamine instead of aqueous ammonia, the same procedure with that of Example 1 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (2:1) as a mobile phase, to obtain 58.9 g of 3-N-meihylcarbamoyl-2-phenyl propanol acetate as a colorless liquid. Yield 91% H-NMR(CDC1. !( 200 MHz ) . ppm ( δ ): 1.95(3II.s), 2.75(3H,d ) , 3.28(lII,q ) . 4.21(4II,d ) .5.15(2II,br). 7.27(5II.m) EXAMPLE 3 Preparation of 3-N,N'-dimethylcarbamoyl-2-phenyl propanol acetate Except for using dimethylamine instead of aqueous ammonia, the same procedure with that of Example 1 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (2- ' l) as a mobile phase, to obtain 63.5 g of 3-N,N'-dimethylcarbamoyl-2-phenyl propanol acetate as a colorless liquid. Yield 93% H-NMR(CDCb. 200 MHz), ppm ( δ ): 1.97(3H.s). 2.78(6H,d), 3.34(1 H.q ) , 4.17(2H.d), 4.39(2H,d ) , 7.32(5II.m) EXAMPLE 4 Preparation of 3-N-isopropyl carbamoyl-2-phenyl propanol acetate Except for using isopropylamine instead of aqueous ammonia, the same procedure with that of Example 1 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (2:1 ) as a mobile phase, to obtain 64.7 g of 3-N-isopropylcarbamoy]-2-phenyl propanol acetate as a colorless liquid. Yield 90% H-NMR(CDCL, 200 MHz), ppm ( δ ): l.ll(6H.s). 1.90(3H,s), 3.35(lH,m), 3.71 (lll.br). 4.43(4H.d). 4.64(lII.br), 7.35(5H.m) EXAMPLE 5 Preparation of 3-N-cyclopropyl carbamoyl-2-phenyl propanol acetate Except for using cyclopropyl amine instead of aqueous ammonia, the same procedure with that of Example 1 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (2:1 ) as a mobile phase, to obtain 67.8 g of 3-N-cyclopropyl carbamoyl-2-phenyl propanol acetate as a colorless liquid. Yield 95% H-NMR(CDC1.;, 200 MHz), ppm ( δ ) : 0.45-0.81((3II.m ). 2.0K3H.S). 2.52(lII.br ) , 3.37(lH,q ) . 4.45(4H,d). 4.87(lII,br), 7.32(5II,m) EXAMPLE 6 Preparation of 3-N-morphoryl carbamoyl-2-phenyl propanol acetate Except for using morphorine instead of aqueous ammonia, the same procedure with that of Example 1 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (2:1 ) as a mobile phase, lo obtain 72.8 g of 3-N-morphorylcarbamoyl-2-phenyl propanol acetate as a colorless liquid. Yield 92% H-NMR(CDCh, 200 MHz), ppm ( δ ): 2.00(3H.s). 3.25-3.73(9II,br), 4.31(4II,d ) . 7.27(5II,m ) EXAMPLE 7 Preparation of 3-N-methylcarbamoyl-2-(o-chlorophenyl) propanol acetate A well dried 1,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 400 ml of purified methylene chloride was poured into the flask. 58.9 g of 3-acetoxy-2-(o-chlorophenyl) propanol was well dissolved in the solvent and made to be homogeneous by stirring for 5 min. While being maintained al O'C, the homogeneous solution was slowly added with 49.8 g of carbonyl diimidazole. After the starting material completely disappeared as measured by thin layer chromatography. 60 ml of an aqueous methylamine solution was slowly added to the reaction solution in order to progress the reaction. To determine when the reaction would be terminated, the reaction was under double monitoring of thin layer chromatography and liquid chromatography. Roughly, il took about 1 hour to finish the reaction. After completion of reaction, 400 ml of distilled water was added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, lo give a yellow liquid. This concentrated liquid mixture was separated by column chromatography using a mixture of ethyl acetate/n-hexane (2:1) as a mobile phase, to obtain 68.5 g of 3-N-methylcarbamoyl-2-(o-chlorophenyl) propanol acetate as a colorless liquid. Yield 93% H-NMR(CDCb, 200 MHz), ppm ( δ ) : 2.05(3II,s), 2.82(d,3H), 3.32(1 Il.q), 4.15-4.27(4H,m), 5.32(1 II.br), 7.23 -7.45(4 II, ) EXAMPLE 8 Preparation of 3-Carbamoyl-2-Phenyl Propanol A well dried 1,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 500 ml of methanol was poured into the flask. 71 g of 3-carbamoyl-2-phenyl propanol acetate prepared in Example 1 was well dissolved in the solvent and made to be homogeneous by stirring for 30 min. While being maintained at O'C, the homogeneous solution was slowly added with 3.3 g of potassium cyanide. The resulting reaction mixture was heated to room temperature with stirring. To determine when the reaction would be terminated, the reaction was under double monitoring of thin layer chromatography and liquid chromatography. Roughly, it took about 2 hours to finish the reaction. After completion of the reaction, 300 ml of saturated ammonium chloride solution was added. Then, using a rotary evaporator, unreacted methanol was completely removed from the reaction solution. 200 ml of distilled water and 500 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. This liquid obtained was added with 300 ml of toluene and stored in a refrigerator for 24 hrs, to prrdnce 51.5 g of 3-carbamoyl-2-phenyl propanol as a white solid. Yield 88% H-NMR(CDCh. 200 MHz ) , ppm ( δ ) : 2.58(lH,t). 3.11 (lH,q ) , 3.82(2H.d ) , 4.39(2II.d ) , 4.91(2H,br ) . 7.27(5II.m) EXAMPLE 9 Preparation of 3-N-methylcarbamoyl-2-phenyl propanol Except for using 3-N-methylcarbamoyl-2-phenyl propanol acetate, instead of 3-carbamoyl-2-phenyl propanol acetate, as the starting material, the same procedure with that of Example 8 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (3:1 ) as a mobile phase, to obtain 58.3 g of 3-N-methylcarbamoyl-2-phenyl propanol as a white solid. Yield 93% H-NMR(DMSO, 200 MHz). ppm ( δ ) : 2.52(3II,d). 3.01(lH,q ) , 3.61(211.0. 4.18(2II,m ) . 4.75(lH,t ) , 6.89 ( lII.d ) , 7.28(5H,m ) EXAMPLE 10 Preparation of 3-N,N'-Dimethylcarbamoyl-2-phenyl propanol Except for using 3-N,N'-dimethylcarbamoyl-2-phenyl propanol acetate, instead of 3-carbamoyl-2-phenyl propanol acetate, as the starting material, the same procedure wilh that of Example 8 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI ) as a mobile phase, lo obtain 60.9 g of 3-N.N'-dimethylcarbamoyl-2-phenyl propanol as a colorless liquid. Yield 91% H-NMR(DMSO. 200 MHz ) , ppm ( δ ) : 2.61 (611.d), 3.10(lH,q), 3.73(2II.d ) . 4.12(2H,d), 4.74(lH.t). 7.34(5II.m) EXAMPLE 11 Preparation of 3-N-Isopropyl carbamoyl-2-phenyl propanol Except for using 3-N-isopropyl carbamoyl-2-phenyl propanol acetate, instead of 3-carbamoyl-2-phenyl propanol acetate, as the starting material, the same procedure with that of Example 8 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to obtain 63.3 g of 3-N-isopropyl carbamoyl-2-phenyl propanol as a white solid. Yield 89% H-NMR(DMSO. 200 MHz ) , ppm ( δ ) : 1.00(6II,d). 2.52(lH,d), 2.95(11-1,0, 3.62(2II.d), 4.18(2H,m ) , 4.74(111,0, 6.91 (lH.d ) , 7.28(5Iϊ.m ) EXAMPLE 12 Preparation of 3-N-Cyclopropyl carbamoyl-2-phenyl propanol Except for using 3-N-cyclopropyl carbamoyl-2-phenyl propanol acetate, instead of 3-carbamoyl-2-phenyl propanol acetate, as the starting material, the same procedure with that of Example 8 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to obtain 65.6 g of 3-N-cyclopropyl carbamoyl-2-phenyl propanol acetate as a white solid. Yield 93% H-NMR(DMSO, 200 MHz ) , ppm ( δ ) : 0.35-0.55(4II,m ), 2.52(lH.s), 3.0K1H.I). 3.61 (2H,d), 4.25(2H.m ) . 4.76(lH.O, 7.14(lH,d ) , 7.28(5H.m ) EXAMPLE 13 Preparation of 3-N-Morphoryl carbamoyl-2-phenyl propanol Except for using 3-N-morphoryl carbamoyl-2-phenyl propanol acetate, instead of 3-carbamoyl-2-phenyl propanol acetate, as the starting material, the same procedure with that of Example 8 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (3:1 ) as a mobile phase, to obtain 71.4 g of 3-N-morphorylcarbamoyl-2-phenyl propanol as a white solid. Yield 90% H-NMR(DMSO, 200 MHz), ppm ): 2.82(lH.br). 3.15(lII,q). 3.27-3.60(8II.br). 3.79(2H,d). 4.35(2II,d), 7.25(5H,m) EXAMPLE 14 Preparation of 3-N-Methylcarbamoyl-2-(o-chlorophenyl) propanol A well dried 1,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 500 ml of methanol was poured into the flask. 85.7 g of 3-N-methylcarbamoyl-2-(o-chlorophenyl) propanol acetate prepared in Example 7 was well dissolved in the solvent and made to be homogeneous by stirring for 30 min. While being maintained at 0°C, the homogeneous solution was slowly added with 3.3 g of potassium cyanide. The resulting reaction mixture was heated to room temperature with stirring. To determine when the reaction would be terminated, the reaction was under double monitoring of thin layer chromatography and liquid chromatography. Roughly, it took about 2 hours to finish the reaction. After completion of the reaction, 300 ml of saturated ammonium chloride solution was added. Then, using a rotary evaporator, unreacted methanol was completely removed from the reaction solution. 200 ml of distilled water and 500 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. This liquid obtained was added with 500 ml of toluene and stored in a refrigerator for 24 hrs, to produce 65.8 g of 3-N-methylcarbamoyl-2-(o-chlorophenyl) propanol as a white solid. Yield 90% H-NMR(CDCI.i, 200 MHz), ppm ( δ ): 2.48(3H.d ) . 2.56(lH,t). 3.13(lH,q ) , 3.87-4.12(4II.br ) , 5.60(lH,br ) , 7.25-7.42(4II,m ) EXAMPLE 15 Preparation of 3-Carbamoyl-2-phenyl propanol sulfamate A well dried 2,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 1.200 ml of purified acetonitrile was poured into the flask. 97.5 g of 3-carbamoyl-2-phenyl propanol prepared in Example 8 and 121.3 ml of pyridine were well dissolved in the solvent and made to be homogeneous by stirring for 30 min. While being maintained at O ' C, the homogeneous solution was slowly added with 115.5 g of sulfamoyl chloride (prepared in the method described in Chem. Ber., 91, 1339-1341 (1958), to Appel and Berger ) . At the same temperature, the reaction was proceeded and its progress was monitored by thin layer chromatography and liquid chromatography. Roughly, it took about 2 hours to finish the reaction. After completion of the reaction, unreacted acetonitrile was completely removed from the reaction solution using a rotary evaporator. Then, 600 ml of distilled water and 600 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. This liquid obtained was added with 500 ml of ethyl ether and stored in a refrigerator for 24 hrs, to produce 116.5 g of 3-carbamoyl-2-phenyl propanol sulfamates a white solid. Yield 85% H-NMR(DMSO, 200 MHz). ppm ) : 3.35(lH,q). 4.16(2H.d), 4.34(2H.d). 6.57(2H,br). 7.39(5H.s). 7.58(2II.s) EXAMPLE 16 Preparation of 3-N-Methylcarbamoyl-2-phenyl propanol sulfamate Except for using 3-N-methylcarbamoy|-2-phenyl propanol, instead of 3-carbamoyl-2-phenyl propanol, as the starting material, the same procedure with that of Example 15 was repeated. A concentrated reaction mixture thus obtained was added with 500 ml of ethyl ether and stored in a refrigerator for 24 hrs, to produce 126.7 g of 3-N-methylcarbamoyl-2-phenyl propanol sulfamate as a white solid. Yield 88 \%^ / II-NMR(DMSO, 200 MHz), ppm(<5 ): 2.54(3II,d ) , 3.35(lII,q), 4.29(4II.m). 6.98(1 H.br). 7.29(5H,s ) , 7.53(211. s ) EXAMPLE 17 Preparation of 3-N,N'-Dimethylcarbamoyl-2-phenyl propanol sulfamate Except for using 3-N.N '-dimethylcarbamoyl-2-phenyl propanol, instead of 3-carbamoyl-2-phenyl propanol, as the starting material, the same procedure with that of Example 15 was repeated. A concentrated reaction mixture thus obtained was added with 500 ml of ethyl ether and stored in a refrigerator for 4 hrs. to produce 125.3 g of 3-N,N'-dimethylcarbamoyl-2-phenyl propanol sulfamate as a white solid. Yield 83% H-NMR(CDCl.i, 200 MHz ) , ppm ): 2.84(6H,d), 3.38(lH,q ) , 4.39(4H,m. 4.93(2II,s). 7.21(5H,d) EXAMPLE 18 Preparation of 3-N-Isopropyl carbamoyl-2-phenyl propanol sulfamate Except for using 3-N-isopropyl carbamoyl-2-phenyl propanol, instead of 3-carbamoyl-2-phenyl propanol, as the starting material, the same procedure with that of Example 15 was repeated. A concentrated reaction mixture thus obtained was added with 500 ml of ethylether and stored in a refrigerator for 24 hrs, to produce 134.3 g of 3-N-isopropyl carbamoyl-2-phenyl propanol sulfamate as a white solid. Yield 85% H-NMR(DMSO, 200 MHz ) , ppmU ): 1.01(6H,m). 3.32(lH.m). 3.55(lH.q), 4.18(2H,d). 4.29(2H.d ) . 6.95(lII.d). 7.34(5H,s), 7.56(2H,s) EXAMPLE 19 Preparation of 3-N-Cyclopropyl carbamoyl-2-phenyl propanol sulfamate Except for using 3-N-cyclopropyl carbamoyl-2-phenyl propanol, instead of 3-carbamoyl-2-phenyl propanol, as the starting material, the same procedure with that of Example 15 was repeated. A concentrated reaction mixture thus obtained was added with 500 ml of ethylether and stored in a refrigerator for 24 hrs, to produce 135.0 g of 3-N-cyclopropyl carbamoyl-2-phenyl propanol sulfamate as a white solid. Yield 86% H-NMR(DMSO, 200MHz) ppm ): 0.35-0.58(4H,m), 2.5K1H.S), 3.35 ( lH,q), 4.15-4.36(4H,m), 7.15 ( 1 IT.br ) . 7.29(5H,s). 7.52(2H.s ) EXAMPLE 20 Preparation of 3-N-Morphoryl carbamoyl-2-phenyl propanol sulfamate Except for using 3-N-morphoryl carbamoyl-2-phenyl propanol, instead of 3-carbamoyl-2-phenyl propanol. as the starting material, the same procedure with that of Example 15 was repeated. The liquid thus obtained was added with 500 ml of ethylether and stored in a refrigerator for 24 hrs, to produce 163.6 g of 3-N-morphorylcarbamoyl-2-phenyl propanol sulfamate as a white solid. Yield 95% H-NMR(CDCI:ι. 200MHz) ppmU ) : 3.05(lII,q) 3.20-3.50(8H.br), 4.15(4H,m).4.43(2H.s), 7.13(5H,m) EXAMPLE 21 Preparation of 3-N-Methylcarbamoyl-2-(o-chlorophenyl) propanol sulfamate A well dried 2,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 1,200 ml of purified acetonitrile was poured into the flask. 121.8 g of 3-N-methylcarbamoyl-2-(o-chlorophenyl ) propanol prepared in Example 14 and 121.3 ml of pyridine were well dissolved in the solvent and made to be homogeneous by stirring for 30 min. While being maintained at 0'C , the homogeneous solution was slowly added with 113.5 g of sulfamoyl chloride (prepared in the method described in Chem. Ber., 91, 1339-1341 (1958 ) , to Appel and Berger). At the same temperature, the reaction was proceeded and its progress was monitored by thin layer chromatography and liquid chromatography. Roughly, it took about 2 hours to finish the reaction. After completion of the reaction, acetonitrile was completely removed from the reaction mixture by using a rotary evaporator. 600 ml of distilled water and 600 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. This liquid obtained was added with 500 ml of ethylether and stored in a refrigerator for 24 hrs, to produce 143.6 g of 3-N-methylcarbamoyl-2-(o-chlorophenyl) propanol sulfamate as a white solid. Yield 89% H-NMIUDMSO, 200 MHz ) . ppm ( δ ) : 2.53(3II.d). 3.32(lH,q), 4.33(4II.m), 6.530II.br). 7.35(4H,m ) , 7.62(211. s) EXAMPLE 22 Preparation of 3-Acetoxy-2-phenyl-l,3-propandiol sulfamate A well dried 1,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 300 ml of purified acetonitrile was poured into the flask. 50 g of 3-acetoxy-2-phenyl propanol and 61 ml of pyridine were well dissolved in the solvent and made to be homogeneous by stirring for 30 min. While being maintained al 0 ' C , the homogeneous solution was slowly added with 59.6 g of sulfamoyl chloride (prepared in the method described in Chem. Ber.. 91. 1339-1341 (1958), to Appel and Berger). Al the same temperature, the reaction was proceeded and its progress was monitored by thin layer chromatography and liquid chromatography. Roughly, il took about 2 hours to finish the reaction. After completion of the reaction, acetonitrile was completely removed from the reaction solution using a rotary evaporator. Then, 300 ml of distilled water and 300 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. This concentrated liquid mixture was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to produce 60.1 g of 3-acetoxy-2-phenyl-l,3-propandiol sulfamate as a while solid. Yield 87% H-NMR(DMSO, 200MHz), ppm ): 1.95(3H,s), 3.360H,q), 4.28(4H,d ) , 7.28(5H,s), 7.53(2H.s ) EXAMPLE 23 Preparation of 2-Phenyl-l,3-propandiol monosulfamate A well dried 1.000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 500 ml of methanol was poured into the flask. 27.3 g of 3-acetoxy- 2-phenyl-l,3-propandiol sulfamate prepared in Example 22 was well dissolved in the solvent and made to be homogeneous by stirring for 30 min. While being maintained at 0 * , the homogeneous solution was slowly added with 3.3 g of potassium cyanide. The resulting reaction mixture was heated to room temperature with stirring. To determine when the reaction would be terminated, the reaction was under double monitoring of thin layer chromatography and liquid chromatography. Roughly, it took about 1 hours lo finish the reaction. After completion of the reaction, 50 ml of saturated ammonium chloride solution was added. Then, using a rotary evaporator, unreacted methanol was completely removed from the reaction solution. 200 ml of distilled water and 200 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow solid. This solid was washed with 50 ml of methylene chloride and purified to produce 19 g of 2-phenyl-l,3-propandiol monosulfamate. Yield 81% H-NMR(DMSO, 200MHz). ppm ): 3.12(lH,q), 3.61(2H,d), 4.24(2II,m), 4.86(lH,t ) , 7.15(5H,m), 7.46(211. s) EXAMPLE 24 Preparation of 3-N-Methylcarbamoyl-2-phenyl propanol sulfamate A well dried 1,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 300 ml of purified methylene chloride was poured into the flask. 23.3 g of 2-phenyl-l,3-propandiol monosulfamate prepared in Example 23 was well dissolved in the solvent and made lo be homogeneous by stirring for 30 min. While being maintained at 0 ' C , the homogeneous solution was slowly added with 19.4 g of carbonyl diimidazole. The resulting reaction mixture was slowly heated to room temperature with stirring. To determine when the reaction would be terminated, the reaction was under double monitoring of thin layer chromatography and liquid chromatography. Roughly. it took about 15 min to finish the reaction. After the starting material completely disappeared, 47 ml of methyl amine aqueous solution was slowly introduced through a syringe with stirring at room temperature. It took about 2 hours to completely terminate this reaction. Then, using a rotary evaporator, the solvent remaining was completely removed from the reaction solution. 200 ml of distilled water and 200 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. This solid was washed with 150 ml of ethyl ether and stored in a refrigerator for 24 hrs, to produce 24.4 g of 3-N-methylcarbamoyl-2-phenyl propanol sulfamate. Yield 85% H-NMR(DMSO, 200MHz). pp ): 2.54(311. d). 3.35(lII.q), 4.29(4II.m), 6.89(lH,br), 7.29(5H,s). 7.53(211. s) EXAMPLE 25 Preparation of 3-Carbamoyl-2-phenyl propanol sulfamate Except for using aqueous ammonia instead of methylamine, the same procedure with that of Example 24 was repeated. A liquid obtained was added with 150 ml of ethyl ether and stored in a refrigerator for 24 hrs to produce 27.0 g of 3-carbamoyl-2-phenyl propanol sulfamate as a while solid. Yield 80% H-NMR(DMSO, 200 MHz), ppm ( δ ) : 3.35(lII.q). 4.16(2H,d). 4.34(2II.d), 6.57(2II,br), 7.39(5H,s). 7.58(211, s). 1.98(3H,s), 3.28(1 Il.q ) EXAMPLE 26 Preparation of 3-N,N'-Dimethylcarbamoyl-2-phenyl propanol sulfamate Except for using dimethylamine instead of methylamine, the same procedure with that of Example 24 was repeated. A liquid obtained was added with 150 ml of ethylether and stored in a refrigerator for 24 hrs. to produce 27.0 g of 3-N,N'-dimethylcarbamoyI-2-phenyl propanol sulfamate as a white solid. Yield 80% II-NMR(DMSO. 200MHz ) , ppmU ): 2.84(6H,d). 3.38(lH,q). 4.39(4II.m). 4.93(2II.s). 7.21(5H.d) EXAMPLE 27 Preparation of 3-N-Isopropyl carbamoyl-2-phenyl propanol sulfamate Except for using isopropyl amine instead of methyl amine the same procedure with that of Example 24 was repeated. A liquid obtained was added with 150 ml of ethylether and stored in a refrigerator for 24 hrs. to produce 26.0 g of 3-N-isopropyl carbamoyl-2-phenyl propanol sulfamate. Yield 82% H-NMR(DMSO, 200MHz ) . ppmU ): l.OKΘII.m). 3.32(lH,m), 3.55(lII,q), 4.18(2H,d), 4.29(2H,d), 6.95(lII.d), 7.34 (5H,s) EXAMPLE 28 Preparation of 3-N-Cyclopropyl carbamoyl-2-phenyl propanol sulfamate Except for using cyclopropyl amine instead of methyl amine, the same procedure with that of Example 24 was repeated. A liquid obtained was added with 150 ml of ethylether and stored in a refrigerator for 24 hrs, to produce 27.6 g of 3-N-cyclopropyl carbamoyl-2-phenyl propanol sulfamate. Yield 88% II-NMR(DMSO, 200MHz ) ppmU ): 0.35-0.58(4H,m), 2.51(lH,s). 3.35(lH.q), 4.16-4.36(4H,m), 7.15UII.br). 7.29(5H,s) EXAMPLE 29 Preparation of 3-N-Morphoryl carbamoyl-2-phenyl propanol sulfamate Except for using morphorine instead of methyl amine, the same procedure with that of Example 24 was repeated. A liquid thus obtained was added with 500 ml of ethylether and stored in a refrigerator for 24 hrs, to produce 32 g of 3-N-morphorylcarbamoyl-2-phenyl propanol sulfamate. Yield 93% II-NMR(DMSO. 200MHz) ppmU ): 3.05(lH,q) 3.20-3.50(8II,br), 4.15(4H,m), 4.43(2H,s). 7.13(5H.m) EXAMPLE 30 Preparation of 3-N-Phenyl carbamoyl-2-phenyl propanol sulfamate A well dried 1.000 ml flask equipped with a thermometer and a condenser was purged with nitrogen gas. to completely take off moisture and air from the inside of Ihe flask. This purging was continued for 30 min, after which 300 ml of purified dichloromethane was poured into the flask. 23.3 g of 2-phenyl-l,3-propandiol monosulfamate prepared in Example 20 was well dissolved in the solvent and made to be homogeneous by stirring for 30 min. While being maintained al room temperature, the homogeneous solution was slowly added with 14.3 g of phenylisocyanate. The resulting solution was slowly heated into 40C with stirring, in order to progress the reaction. To determine when the reaction would be terminated, the reaction was under double monitoring of thin layer chromatography and liquid chromatography. Roughly, it took about 6 hours to finish the reaction. After completion of reaction, dichloromethane remaining was removed from the solution by use of a rotary evaporator. 100 ml of distilled water and 100 ml of ethyl acetate was added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, lo give a yellow liquid. This concentrated liquid mixture was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI ) as a mobile phase, to obtain 24.5 g of 3-N-phenyl carbamoyl-2-phenyl propanol sulfamate. Yield 70% II -NMR (CDC 1 :1 . 200MHz), ppmU ): 3.46(lH,m), 4.41 (4H,m), 5.05(2IT,br). 7.05(lII,br), 7.31(10H,m) EXAMPLE 31 Preparation of (S)-3-Carbamoyl-2-phenyl propanol acetate A well dried 1,000 ml flask equipped with a thermometer was purged wilh nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 500 ml of purified methylene chloride was poured into the flask. 50 g of (R)-3-acetoxy-2-phenyl propanol was well dissolved in the solvent and made lo be homogeneous by stirring for 5 min. While being maintained at 0'C , the homogeneous solution was slowly added with 49.8 g of carbonyl diimidazole. After the starling material completely disappeared as measured by thin layer chromatography, 43.8 ml of aqueous ammonia was slowly added to the reaction solution in order to progress the reaction. To determine when the reaction would be terminated, the reaction was under double monitoring of thin layer chromatography and liquid chromatography. Roughly, it took about 2 hours to finish the reaction. After completion of reaction, 500 ml of distilled water was added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. This concentrated liquid mixture was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to obtain 56.2 g of (S)-3-carbamoyl-2-phenyl propanol acetate. Yield 92% H-NMR(DMSO. 200MHz ) . ppmU ): 1.98(3H,s). 3.28(lH,q).4.28(4H,d), 5.21 (2II.br). 7.27(5H,m) EXAMPLE 32 Preparation of (S ) -3-N-melhylcarbamoyl-2-phenyl propanol acetate Except for using methylamine instead of aqueous ammonia, the same procedure with that of Example 31 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to obtain 58.2 g of (S)-3-N-methylcarbamoyl-2-phenyl propanol acetate as a colorless liquid. Yield 90% H-NMR(CDCI.i. 200MHz ) , ppm ) : 1.95(3H,s ) . 2.75(3II.d). 3.28(lII.q). 4.21(4II.d). 5.15( 1 II.br). 7.27(5H,m ) EXAMPLE 33 Preparation of (S ) -3-N,N '-dimethylcarbamoyl-2-phenyl propanol acetate Except for using dimethylamine instead of aqueous ammonia, the same procedure with that of Example 31 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to obtain 62.8 g of (S)-3-N,N'-dimethylcarbamoyl-2-phenyI propanol acetate as a colorless liquid. Yield 92% II-NMR(CDCI.i, 200MHz ) . ppmU ): 1.97(3H.s). 2.78(6II.d). 3.34(lII,q), 4.17(2II.d). 4.39(2H.d ) . 7.32(5H.m ) EXAMPLE 34 Preparation of (S ) -3-N-isopropyl carbamoyl-2-phenyl propanol acetate Except for using isopropylamine instead of aqueous ammonia, the same procedure with that of Example 31 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, lo obtain 66.9 g of (S)-3-N-isopropylcarbamoyl-2-phenyl propanol acetate as a colorless liquid. Yield 93% H-NMR(CDCl.i. 200MHz ) . ppmU ): l.ll(6H.m), 1.90(3H,s ) , 3.35(lH.m ) , 3.71(lH,br). 4.43(4H,d), 4.64(1 II.br), 7.35(5H,m ) EXAMPLE 35 Preparation of (S ) -3-N-cyclopropyl carbamoyl-2-phenyl propanol acetate Except for using cyclopropyl amine instead of aqueous ammonia, the same procedure with that of Example 31 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI ) as a mobile phase, lo obtain 64.2 g of (S)-3-N -cyclopropyl carbamoyl-2-phenyl propanol acetate as a colorless liquid. Yield 90% II-NMR(CDC1:>„ 200MHz), ppm ): 0.45-0.81 (6II,m ), 2.0K3H.S), 2.52(lH,br ) , 3.37(lH,q ) , 4.45(4H,d ) , 4.87(1 II.br), 7.32(5H,m ) EXAMPLE 36 Preparation of (S ) -3-N-morphoryl carbamoyl-2-phenyl propanol acetate Except for using morphorine instead of aqueous ammonia, the same procedure with that of Example 31 was repeated. A concentraled reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI ) as a mobile phase, to obtain 75.2 g of (S ) -3-N-morphorylcarbamoyl-2-phenyl propanol acetate as a colorless liquid. Yield 95% H-NMR(CDCl.s. 200MHz), ppmU ): 2.00(3H,s), 3.25-3.73(9H.br ) . 4.31 (4H,d), 7.27(5H,m ) EXAMPLE 37 Preparation of (S ) -3-N-methylcarbamoyl-2-(m-chloro phenyl) propanol acetate A well dried 1,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 500 ml of purified methylene chloride was poured into the flask. 58.9 g of (R)-3-acetoxy-2-(m-chlorophenyl) propanol was well dissolved in the solvent and made to be homogeneous by stirring for 5 min. While being maintained at 0' , the homogeneous solution was slowly added with 49.8 g of carbonyl diimidazole. After the starling material completely disappeared as measured by thin layer chromatography, 60 ml of an aqueous methylamine solution was slowly added to the reaction solution in order to progress the reaction. To determine when the reaction would be terminated, the reaction was under double monitoring of thin layer chromatography and liquid chromatography. Roughly, it took about 2 hours to finish the reaction. After completion of reaction, 500 ml of distilled water was added for solvenl extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. This concentrated liquid mixture was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to obtain 71.2 g of (S)-3-N-methylcarbamoyl-2-(m-chlorophenyl) propanol acetate. Yield 90% II-NMR(DMSO. 200MHz). ppmU ): 2.12(3H,s), 2.90(d,3H), 3.31(lH.q ) , 4.12-4.31 (4II.m). 5.52(1 II.br), 7.28- 7.41 (4H,m) EXAMPLE 38 Preparation of (S)-3-Carbamoyl-2-phenyl propanol A well dried 1,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min. after which 500 ml of methanol was poured into the flask. 47.4 g of (S)-3-carbamoyl-2-phenyl propanol acetate prepared in Example 31 was well dissolved in the solvent and made to be homogeneous by stirring for 30 min. While being maintained at 0( , the homogeneous solution was slowly added with 3.9 g of potassium cyanide. The resulting reaction mixture was healed to room temperature with stirring. To determine when the reaction would be terminated, the reaction was under double monitoring of thin layer chromatography and liquid chromatography. Roughly, it took about 2 hours to finish the reaction. After completion of the reaction, 200 ml of saturated ammonium chloride solution was added. Then, using a rotary evaporator, un reacted methanol was completely removed from the reaction solution. 200 ml of distilled water and 400 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. This liquid obtained was added with 200 ml of toluene and stored in a refrigerator for 24 hrs, to produce 35.5 g of (S)-3-carbamoyl-2-phenyl propanol as a white solid. Yield 91% II-NMR(CDCI. ; , 200MHz), ppmU ): 2.58(11-1,0. 3.11(lII,q). 3.82(2II.d). 4.39 ( 2II.d ) . 4.91 (2II.br). 7.27(5II,m ) EXAMPLE 39 Preparation of (S ) -3-N-methylcarbamoyl-2-phenyl propanol Except for using ( S ) -3-N-methylcarbamoyl-2-phenyl propanol acetate, instead of (S ) -3-carbamoyl-2-phenyl propanol acetate, as the starting material, the same procedure with that of Example 38 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to obtain 37.2 g of (S)-3-N-methylcarbamoyl-2-phenyl propanol as a white solid. Yield 89% II-NMR(DMSO. 200MHz), ppm( δ ): 2.52(3H,d). 3.01(lH.q). 3.61(211.0, 4.18(2H,m ) , 4.75(111,0, 6.98(1 Il.d), 7.28(51-1 ,m ) EXAMPLE 40 Preparation of (S)-3-N,N'-Dimethylcarbamoyl -2-phen propanol Except for using (S)-3-N,N'-dimethylcarbamoyl- 2-phenyl propanol acetate, instead of (S)-3-carbamoyl- 2-phenyl propanol acetate, as the starting material, the same procedure with that of Example 38 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, lo obtain 38.8 g of (S)-3-N,N'-dimelhylcarbamoyl-2-phenyI propanol as a colorless liquid. Yield 87% H-NMR(DMSO, 200MHz), ppmU ): 2.61(6H.d), 3.10(lH,q), 3.73(2II,d). 4.12(2II,m), 4.74(lH,t). 7.34 (5H,m ) EXAMPLE 41 Preparation of (S ) -3-N-Isopropyl carbamoyl-2-phenyl propanol Except for using (S)-3-N-isopropyl carbamoyl-2- phenyl propanol acetate, instead of (S)-3-carbamoyl-2- phenyl propanol acetate, as the starting material, the same procedure with that of Example 38 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to obtain 41.7 g of (S)-3-N-isopropyl carbamoyl-2-phenyl propanol as a white solid. Yield 88% H-NMR(DMSO, 200MHz), ppm ): 1.00(6H,d), 2.52(lII,d). 2.95(1H,0, 3.62(2H,d), 4.18(2H,m ) , 4.74(111,0, 6.91 OH.d ) . 7.28 ( 5H,m ) EXAMPLE 42 Preparation of (S ) -3-N-Cyclopropyl carbamoyl- 2-phenyl propanol Except for using (S ) -3-N-cyclopropyl carbamoy|-2- phenyl propanol acetate, instead of (S)-3-carbamoyl- 2-phenyl propanol acetate, as the starting material, the same procedure with lhat of Example 38 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, lo obtain 42.8 g of (S)-3-N -cyclopropyl carbamoyl-2-phenyl propanol as a white solid. Yield 91% H-NMR(DMSO, 200MHz ) , ppmU ) : 0.35-0.55(4II,m ), 2.52(lII.s ) . 3.01(111,1 ) . 3.61(2II.d ) . 4.25(2H.m ) , 4.76(111.0. 7.14(lH,d ) . 7.28(5II.m) EXAMPLE 43 Preparation of (S ) -3-N-Morphoryl carbamoyl-2-phenyl propanol Except for using (S)-3-N-morphoryl carbamoyl-2- phenyl propanol acetate, instead of (S ) -3-carbamoyl-2- phenyl propanol acetate, as the starting material, the same procedure with that of Example 38 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI ) as a mobile phase, lo obtain 47.2 g of (S)-3-N-morphorylcarbamoyl-2-phenyl propanol as a white solid. Yield 89% II-NMR(DMSO, 200MHz). ppmU ): 2.82(lII,br). 3.15(lH,q). 3.27-3.60(8II,br), 3.79(2II,d), 4.35(2H.d). 7.25 (5H,m ) EXAMPLE 44 Preparation of (S ) -3-N-Methylcarbamoyl-2- ( m -chloro phenyl) propanol A well dried 1,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 500 ml of methanol was poured into the flask. 69.5 g of (S)-3-N-methylcarbamoyl-2-(m-chlorophenyl) propanol acetate prepared in Example 37 was well dissolved in the solvent and made to be homogeneous by stirring for 30 min. While being maintained at O'C, the homogeneous solution was slowly added with 3.9 g of potassium cyanide. The resulting reaction mixture was heated to room temperature with stirring. To determine when the reaction would be terminated, the reaction was under double monitoring of thin layer chromatography and liquid chromatography. Roughly, it took about 2 hours to finish the reaction. After completion of the reaction, 200 ml of saturated ammonium chloride solution was added. Then, using a rotary evaporator, unreacted methanol was completely removed from the reaction solution. 200 ml of distilled 10 water and 400 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. ,,- This liquid obtained was added with 300 ml of toluene and stored in a refrigerator for 24 hrs, to produce 50.5 g of (S)-3-N-methylcarbamoyl-2-(m-chlorophenyl) propanol as a white solid. Yield 85% 20 II-NMR(CDCI:t. 200MHz ) . ppmU ): 2.41(3H.d). 2.51(11-1.0. 3.20(lH,q ) . 3.92-4.15(4H,br ) , 5.58(lII.br). 7.30-7.49(4II,m ) EXAMPLE 45 or Preparation of (R ) -3-Carbamoyl-2-phenyl propanol sulfamate A well dried 2,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 1,200 ml of purified acetonitrile was poured into the flask. 58.5 g of (S)-3-carbamoyl-2-phenyl propanol prepared in Example 38 and 156.8 ml of diisopropyl ethylamine were well dissolved in the solvent and made to be homogeneous by stirring for 30 min. While being maintained at 0"C, the homogeneous solution was slowly added with 69.3 g of sulfamoyl chloride (prepared in the method described in Chem. Ber., 91. 1339-1341 (1958 ) , to Appel and Berger ) . At the same temperature, the reaction was proceeded and its progress was monitored by thin layer chromatography and liquid chromatography. Roughly, il took about 2 hours to finish the reaction. After completion of the reaction, unreacted acetonitrile was completely removed from the reaction solution using a rotary evaporator. Then, 600 ml of distilled water and 600 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. This liquid obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase. to obtain 73.2 g of (R)-3-carbamoyl-2-phenyl propanol sulfamates a white solid. Yield 89% II-NMR(DMSO, 200MHz). ppmU ): 3.35(lII.q). 4.16(2H,d). 4.34(2H.d ) .6.57(2H.br). 7.39(5H,s). 7.58(2H,s) EXAMPLE 46 Preparation of ( R ) -3-N-Methylcarbamoyl-2-phenyl propanol sulfamate Except for using (S ) -3-N-methylcarbamoyl-2-phenyl propanol, instead of (S ) -3-carbamoyl-2-phenyl propanol. as the starting material, the same procedure with that of Example 45 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI ) as a mobile phase, lo obtain 76.9 g of (R)-3-N-methylcarbamoyl-2-phenyl propanol sulfamate as a white solid. Yield 89% H-NMR(DMSO, 200MIIz), ppmU ): 2.54(3II.d), 3.35(lH,q), 4.29(4II.m), 6.98(lII,br).7.29(511. s). 7.53(2II.s) EXAMPLE 47 Preparation of (R ) -3-N,N'-Dimethylcarbamoyl-2- phenyl propanol sulfamate Except for using (S ) -3-N,N'-dimethylcarbamoyl- 2-phenyl propanol, instead of (S ) -3-carbamoyl-2-phenyl propanol, as the slarting material, the same procedure with that of Example 45 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixlure of ethyl acetate/n-hexane (LI) as a mobile phase, to obtain 77.9 g of (R)-3-N,N'-dimethylcarbamoyl-2-phenyl propanol sulfamate as a white solid. Yield 86% II-NMR(CDCh, 200MHz), ppm ): 2.84(6II,d ) . 3.38(lH,q ) .4.39(4H,m), 4.93(211. s).7.21 (5H.d ) EXAMPLE 48 Preparation of (R)-3-N-Isopropyl carbamoyl-2-phenyl propanol sulfamate Except for using (S)-3-N-isopropyl carbamoyl-2- phenyl propanol, instead of (S ) -3-carbamoyl-2-phenyl propanol, as the starting material, the same procedure with that of Example 45 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI ) as a mobile phase, to obtain 79.6 g of (R ) -3-N-isopropyl carbamoyl-2-phenyl propanol sulfamate as a while solid. Yield 84% H-NMR(DMSO, 200MHz ) , ppm ): 1.01(6H,m), 3.32(1 H.m ) . 3.55(1 H.q ) , 4.18(2II.d), 4.29(2H,d), 6.95(lH.d). 7.34(5II.s). 7.56(2H.s) EXAMPLE 49 Preparation of (R)-3-N-Cyclopropyl carbamoyl-2- phenyl propanol sulfamate Except for using (S ) -3-N-cyclopropyl carbamoyl-2- phenyl propanol. instead of (S)-3-carbamoy|-2-phenyl propanol, as the starting material, the same procedure with that of Example 45 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to produce 84.8 g of (R)-3-N -cyclopropyl carbamoyl-2-phenyl propanol sulfamate as a while solid. Yield 90% II-NMR(DMSO, 200MHz ) ppmU ) : 0.35-0.58(4Il,m ), 2.5K1II.S). 3.35(lH.q ) , 4.16-4.36(4H.m). 7.15(1 II.br), 7.29(5H.s), 7.52(2H,s) EXAMPLE 50 Preparation of (R ) -3-N-Morphoryl carbamoyl-2-phenyl propanol sulfamate Except for using (S ) -3-N-morphoryl carbamoyl- 2-phenyl propanol, instead of (S)-3-carbamoyl-2-phenyl propanol, as the starling material, the same procedure with that of Example 45 was repeated. The liquid thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to produce 87.8 g of (R)-3-N-morphorylcarbamoyl-2-phenyl propanol sulfa ate as a white solid. Yield 85% H-NMR(DMSO, 200MHz) ppm ): 3.05(lH.q), 3.20-3.50(8II.br). 4.15(4II.m).4.43(2H,s), 7.13(5Il.m) EXAMPLE 51 Preparation of (R)-3-N-Methylcarbamoyl-2-(m-chloro phenyl) propanol sulfamate A well dried 2.000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 1,200 ml of purified acetonitrile was poured into the flask. 73.1 g of (S ) -3-N-methylcarbamoyl-2-(m-chlorophenyl ) propanol prepared in Example 44 and 156.8 ml of diisopropyl ethylamine were well dissolved in the solvent and made to be homogeneous by stirring for 30 min. While being maintained at 0 ' (Y the homogeneous solution was slowly added with 69.3 g of sulfamoyl chloride (prepared in the method described in Chem. Ber., 91. 1339-1341 (1958). to Appel and Berger ) . At the same temperature, the reaction was proceeded and ils progress was monitored by Ihin layer chromatography and liquid chromatography. Roughly, it took about 2 hours to finish the reaction. After completion of the reaction, acetonitrile remaining was completely removed from the reaction mixture by using a rotary evaporator. 600 ml of distilled water and 600 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. This liquid obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to produce 73.2 g of (R)-3-N-methylcarbamoyl-2-(m-chlorophenyl) propanol sulfamate as a white solid. Yield 89% H-NMR(DMSO, 200 MHz ) , ppm ( δ ) : 2.50(3H,d). 3.35(11-I.q). 4.28 ( 4H,m ) . 6.52(lII,br). 7.38(4H.m), 7.56(2H,s) EXAMPLE 52 Preparation of (S)-3-Aceloxy-2-phenyl-l,3-propandiol sulfamate A well dried 1,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 300 ml of purified acetonitrile was poured into the flask. 50 g of (R)-3-acetoxy-2-phenyl propanol and 61 ml of pyridine were well dissolved in the solvent and made lo be homogeneous by stirring for 30 min. While being maintained at 0'C, the homogeneous solution was slowly- added with 59.6 g of sulfamoyl chloride (prepared in the method described in Chem. Ber., 91, 1339-1341 (1958), to Appel and Berger). At the same temperature, the reaction was proceeded and its progress was monitored by thin layer chromatography and liquid chromatography. Roughly, il took about 2 hours lo finish the reaction. After completion of the reaction, acetonitrile was completely removed from the reaction solution using a rotary evaporator. Then, 300 ml of distilled water and 300 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. This concentrated liquid mixture was separated by 0 column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to produce 61.3 g of (S)-3-acetoxy-2-phenyl-l,3-propandiol sulfamate as a white solid. Yield 88% 5 II-NMR(DMSO. 200MIIz), ppmU ): 1.95(3II.s), 3.36(lII,q).4.28(4H,d ) , 7.28(511, s ) . 7.53(2H,s) EXAMPLE 53 0 Preparation of (S)-2-Phenyl-l,3-propandiol monosulfamate A well dried 1,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely ^ take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 500 ml of methanol was poured into the flask. 27.3 g of (S)-3-acetoxy-2-phenyl-l,3-propandiol sulfamate prepared in Example 52 was well dissolved in the solvent and made lo be homogeneous by stirring for 30 min. While being maintained al O ' CY the homogeneous solution was slowly added with 3.3 g of potassium cyanide. The resulting reaction mixture was heated to room temperature with stirring. To determine when the reaction would be terminated, the reaction was under double monitoring of thin layer chromatography and liquid chromatography. Roughly, it took about 4 hours to finish the reaction. After completion of the reaction, 50 ml of saturated ammonium chloride solution was added. Then, using a rotary evaporator, unreacted methanol was completely removed from the reaction solution. 200 ml of distilled water and 200 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, lo give a yellow solid. This solid was washed with 50 ml of methylene chloride and filtered to produce 19 g of (S)-2-phenyl-l,3-propandiol monosulfamate as a white solid. Yield 81% II-NMR(DMSO.200MHz). ppmU ) : 3.12(1 IT . >, 3.61(2H.d). 4.24(2II,m), 4.86(111, 0, 7.15(5H,m ) , 7.46(2II,s ) EXAMPLE 54 Preparation of ( S ) -3-N-Methylcarbamoyl-2-phenyl propanol sulfamate A well dried 1,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 300 ml of purified methylene chloride was poured into the flask. 23.3 g of (S)-2-phenyl- 1,3-propandiol monosulfamate prepared in Example 53 was well dissolved in the solvent and made to be homogeneous by stirring for 30 min. While being maintained at O'C, the homogeneous solution was slowly added with 19.4 g of carbonyl diimidazole. The resulting reaction mixture was slowly heated to room temperature with stirring. To determine when the reaction would be terminated, the reaction was under double monitoring of thin layer chromatography and liquid chromatography. Roughly, it took about 15 mins to finish the reaction. After the starting material completely disappeared, 47 ml of methyl amine aqueous solution was slowly introduced through a syringe with stirring at room temperature. It took about 2 hours to completely terminate this reaction. Then, using a rotary evaporator, the solvent remaining was completely removed from the reaction solution. 200 ml of distilled water and 200 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off Ihe solvent by a rotary evaporator, to give a yellow liquid. This liquid was added with 150 ml of ethyl ether and stored in a refrigerator for 24 hrs, to produce 24.4 g of (S)-3-N -meth yicarbamoy 1-2- phenyl propanol sulfamate. Yield 85% II-NMR(DMSO, 200MHz), ppm ): 2.54(3II,d). 3.35(lH,q). 4.29(4H.m), 6.98(lII.br). 7.29(5H.s). 7.53(2H,s) EXAMPLE 55 Preparation of (S)-3-Carbamoyl-2-phenyl propanol sulfamate Except for using aqueous ammonia instead of methylamine, the same procedure with that of Example 54 was repeated. A liquid obtained was added with 150 ml of ethyl ether and stored in a refrigerator to produce 27.0 g of (S)-3-carbamoyl-2-phenyl propanol sulfamate as a white solid. Yield 80% IΪ-NMR(DMSO. 200MIIz), ppmU ): 3.35(lII,q). 4.16(2II.d ) . 4.34(2H.d ) , 6.57(2II,br), 7.39(5H,s). 7.58(2H,s), 1.98(3H,s), 3.28(lH,q) EXAMPLE 56 Preparation of (S)-3-N,N'-Dimethylcarbamoyl- 2-phenyl propanol sulfamate Except for using dimethylamine instead of methylamine, the same procedure with that of Example 54 was repeated. A liquid obtained was added with 150 ml of ethylether and stored in a refrigerator for 24 hrs, to produce 27.0 g of (S)-3-N,N'-dimethylcarbamoyl-2-phenyl propanol sulfamate as a white solid. Yield 80% II-NMR(DMSO, 200MHz ) . ppmU ) : 2.84(6II,d ) . 3.38(lH,q). 4.39(4H,m ) , 4.93(2H,s ) , 7.21 (5H,d ) EXAMPLE 57 Preparation of (S)-3-N ~ Isopropyl carbamoyl-2-phenyl propanol sulfamate Except for using isopropyl amine instead of methyl amine the same procedure with that of Example 54 was repeated. A liquid obtained was added with 150 ml of ethylether and stored in a refrigerator for 24 hrs, to produce 26.0 g of (S)-3-N-isopropyl carbamoyl-2-phenyl propanol sulfamate. Yield 82% H-NMR(DMSO, 200MIIz ) , ppmU ): 1.01(6II.m). 3.32(lH,m ) , 3.55 ( lH,q ) , 4.18(2II,d). 4.29(2H.d). 6.95(lII.d), 7.34 ( 5II,s ) EXAMPLE 58 Preparation of (S ) -3-N-Cyclopropyl carbamoyl-2- phenyl propanol sulfamate Except for using cyclopropyl amine instead of methyl amine, the same procedure with that of Example 54 was repeated. A liquid obtained was added with 150 ml of ethylelher and stored in a refrigerator for 24 hrs, to produce 27.6 g of (S)-3-N-cyclopropyl carbamoyl-2-phenyl propanol sulfamate. Yield 88% H-NMR(DMSO, 200MHz ) ppm ) : 0.35-0.58(4II,m), 2.51(lH,s), 3.35(lH,q ) , 4.16-4.36(4H.m), 7.15(1 II.br). 7.29(5H,s) EXAMPLE 59 Preparation of (S ) -3-N-Morphoryl carbamoyl-2-phenyl propanol sulfamate Except for using morphorine instead of methyl amine, the same procedure with that of Example 54 was repeated. A liquid thus obtained was added with 500 ml of ethylether and stored in a refrigerator for 24 hrs, lo produce 33 g of (S)-3-N-morphoryl carbamoyI-2-phenyI propanol sulfamate. Yield 96% II-NMR(DMSO, 200MHz) ppmU ) : 3.05(lII.q) 3.20-3.50(8II,br), 4.15(4II.m), 4.43(2II,s), 7.13(5II.m) EXAMPLE 60 Preparation of (R )-3-Carbamoyl-2-phenyl propanol acetate A well dried 1,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 500 ml of purified methylene chloride was poured into the flask. 50 g of (S)-3-acetoxy-2-phenyl propanol was well dissolved in the solvent and made to be homogeneous by stirring for 5 min. While being maintained at 0 ° C, the homogeneous solution was slowly added with 49.8 g of carbonyl diimidazole. After the starting material completely disappeared as measured by thin layer chromatography, 43.8 ml of aqueous ammonia was slowly added to the reaction solution in order to progress the reaction. To determine when the reaction would be terminated, the reaction was under double monitering of thin layer chromatography and liquid chromatography. Roughly, il took about 2 hours lo finish the reaction. After completion of reaction. 500 ml of distilled water was added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. This concentrated liquid mixture was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to obtain 55 g of (R)-3-carbamoyl-2-phenyl propanol acetate. Yield 90% H-NMR(DMSO. 200MHz ) , ppm (5 : 1.98(3II,s). 3.28(lH,(i), 4.28(4II.d ) , 5.21 (2II.br ) , 7.27(5H,m ) EXAMPLE 61 Preparation of (R ) -3-N-methylcarbamoyl-2-phenyl propanol acetate Except for using methylamine instead of aqueous ammonia, the same procedure with that of Example 60 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI ) as a mobile phase, to obtain 62.1 g of (R ) -3- -methylcarbamoyl-2-phenyl propanol acetate as a colorless liquid. Yield 96% II-NMR(CDCI; i , 200MHz), ppm ): 1.95(3H,s). 2.75(3II.d). 3.28(lII,q), 4.21(4II,d), 5.15(1 II.br). 7.27(5H.m) EXAMPLE 62 Preparation of (R ) -3-N,N'-dimethylcarbamoyl-2-phenyl propanol acetate Except for using dimelhylamine instead of aqueous ammonia, the same procedure with that of Example 60 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to obtain 61.4 g of (R)-3-N,N '-dimethylcarbamoyl-2-phenyl propanol acetate as a colorless liquid. Yield 90% H-NMR(CDCL, 200MHz). ppmU ): 1.97(3II.s). 2.78(6II,d ) . 3.34 ( lII.q ) . 4.17(2II.d). 4.39(2H.d), 7.32(5II,m ) EXAMPLE 63 Preparation of (R ) -3-N-isopropyl carbamoyl-2-phenyl propanol acetate Except for using isopropylamine instead of aqueous ammonia, the same procedure with that of Example 60 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI ) as a mobile phase, lo obtain 65.5 g of (R )-3-N-isopropylcarbamoyl-2-phenyl propanol acetate as a colorless liquid. Yield 91% H-NMR(CDCI.i. 200MHz), ppmU ): l.ll(6II,m), 1.90(3H.s). 3.35(lII,m). 3.71 ( lIT.br ) . 4.43(4II,d ) , 4.64(lH.br). 7.35(5II,m) EXAMPLE 64 Preparation of (R )-3-N -cyclopropyl carbamoyl-2- phenyl propanol acetate Except for using cyclopropyl amine instead of aqueous ammonia, the same procedure with that of Example 60 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI ) as a mobile phase, to obtain 66.3 g of (R)-3-N -cyclopropyl carbamoyl-2-phenyl propanol acetate as a colorless liquid. Yield 93% H-NMR(CDCh, 200MHz), ppmU ) : 0.45-0.81 (6II.m ). 2.01 (3H.s). 2.52(1 IT.br). 3.37(lII.q).4.45(4H,d). 4.87(1 II.br). 7.32 (5H.m ) EXAMPLE 65 Preparation of (R ) -3-N-morphoryl carbamoyl-2-phenyl propanol acetate Except for using morphorine instead of aqueous ammonia, the same procedure with that of Example 60 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixlure of ethyl acetate/n-hexane (LI) as a mobile phase, lo obtain 70.5 g of (R ) -3-N-morphorylcarbamoyl-2-phenyl propanol acetate as a colorless liquid. Yield 89% II-NMR(CDCI.i, 200MHz), ppmU ): 2.00(311, ), 3.25-3.73(9II,br ) . 4.31(4II.d), 7.27(5H,m) EXAMPLE 6G Preparation of (R ) -3-N-methylcarbamoyl-2-(p- methoxyphenyl) propanol acetate A well dried 1,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 500 ml of purified methylene chloride was poured into the flask. 57.8 g of (S)-3-acetoxy-2-(p-methoxyphenyl ) propanol was well dissolved in the solvent and made to be homogeneous by stirring for 5 min. While being maintained at 0( , Ihe homogeneous solution was slowly added with 49.8 g of carbonyl diimidazole. After the starting material completely disappeared as measured by thin layer chromatography, 60 ml of an aqueous methylamine solution was slowly added to the reaction solution in order to progress the reaction. To determine when the reaction would be terminated, the reaction was under double monitering of thin layer chromatography and liquid chromatography. Roughly, it took about 2 hours to finish the reaction. After completion of reaction, 500 ml of distilled water was added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. This concentrated liquid mixture was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to obtain 69.6 g of (R )-3- N- meth ylcarbamoyl- 2- (p- methoxy phenyl) propanol acetate. Yield 96% II-NMR(DMSO, 200MHz ) , ppmU ): 2.12(3II.s), 2.85(d.3II). 3.25 ( 1 H.q). 4.20-4.32(4II,m), 5.24(1 II.br). 6.89(2H,d). 7.23 ( 2II.d ) EXAMPLE 67 Preparation of (R ) -3-Carbamoyl-2-phenyl propanol A well dried 1,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min. after which 500 ml of methanol was poured into the flask. 47.4 g of (R)-3-carbamoyl-2-phenyl propanol acetate prepared in Example 60 was well dissolved in the solvent and made to be homogeneous by stirring for 30 min. While being maintained at 0( , the homogeneous solution was slowly added with 3.9 g of potassium cyanide. The resulting reaction mixture was heated to room temperature with stirring. To determine when the reaction would be terminated, the reaction was under double monitering of thin layer chromatography and liquid chromatography. Roughly, it took about 2 hours to finish the reaction. After completion of the reaction, 200 ml of saturated ammonium chloride solution was added. Then, using a rotary evaporator, unreacted methanol was completely removed from the reaction solution. 200 ml of distilled water and 400 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, lo give a yellow liquid. This liquid obtained was added with 200 ml of toluene and stored in a refrigerator for 24 hrs, to produce 36.7 g of (R)-3-carbamoyl-2-phenyl propanol as a white solid. Yield 94% II-NMR(CDCb, 200MHz), ppm ): 2.58(111.0, 3.11(lH.q). 3.82(2H,d), 4.39(2II,d), 4.91 (2H.br ) , 7.27(5II,m) EXAMPLE 68 Preparation of ( R >-3-N-methylcarbamoyl-2-phenyl propanol Except for using (R ) -3-N-methylcarbamoyl-2-phenyl propanol acetate, instead of (R ) -3-carbamoyl-2-phenyl propanol acetate, as the starling material, the same procedure with that of Example 67 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to obtain 38.9 g of (R)-3-N-methylcarbamoyl-2-phenyl propanol as a white solid. Yield 93% II-NMR(DMSO. 200MHz). ppmU ) : 2.52(3II.d), 3.01 (lH.q ) , 3.61(21-1.0. 4.18(2II.m ) . 4.75(1H,0, 6.98(1 H.d). 7.28(5H,m) EXAMPLE 69 Preparation of (R)-3-N,N'-Dimethylcarbamoyl-2 phenyl propanol Except for using (R)-3-N.N'-dimethylcarbamoyl-2- phenyl propanol acetate, instead of (R ) -3-carbamoy|-2- phenyl propanol acetate, as the starling material, the same procedure with thai of Example 67 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to obtain 41.5 g of (R ) -3-N,N '-dimelhylcarbamoyl-2-phenyl propanol as a colorless liquid. Yield 93% H-NMR(DMSO. 200MIIz), ppmU ): 2.61 (6IT.d ), 3.10(lH,q).3.73(2II,d ) , 4.12(2II,m), 4.74(111.0. 7.34(5II,m) EXAMPLE 70 Preparation of (R )-3-N-Isopropyl carbamoyl-2-phenyl propanol Except for using (R )-3-N-isopropyl carbamoyl-2- phenyl propanol acetate, instead of (R)-3-carbamoyl-2- phenyl propanol acetate, as the starling material, the same procedure with thai of Example 67 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, lo obtain 42.6 g of (R)-3-N-isopropyl carbamoyl-2-phenyl propanol as a white solid. Yield 90% H-NMR(DMSO. 200MHz), ppm (5 ) : 1.00(6II.d). 2.52(lII.d ) . 2.95(111,0. 3.62(2II.d). 4.18(2II,m). 4.74(111,0. 6.91(lII,d ) , 7.28(5II,m ) EXAMPLE 71 Preparation of (R ) -3-N-Cyclopropyl carbamoyl-2- phenyl propanol Except for using (R ) -3-N-cyclopropyl carbamoyl-2- phenyl propanol acetate, instead of (R)-3-carbamoyl- 2-phenyl propanol acetate, as the starting material, the same procedure with that of Example 67 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI ) as a mobile phase, to obtain 44.2 g of (R)-3-N -cyclopropyl carbamoyI-2-phenyl propanol as a white solid. Yield 94% II-NMR(DMSO, 200MIIz), ppm ): 0.35-0.55(4II,m ). 2.52(lH,s). 3.01(11-1.0. 3.61 (2H,d). 4.25(2H,m). 4.76(11-1,0. 7.14(lH.d ) , 7.28(5H,m ) EXAMPLE 72 Preparation of ( R ) -3-N-Morphoryl carbamoyl-2-phenyl propanol Except for using (R)-3-N-morphoryl carbamoyl-2-phenyl propanol acetate, instead of (R)-3-carbamoyl-2-phenyl propanol acetate, as the starting material, the same procedure with that of Example 67 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI ) as a mobile phase, to obtain 48.3 g of (R)-3-N-morphorylcarbamoyl-2-phenyl propanol as a white solid. Yield 91% H-NMR(DMSO, 200MHz), ppmU ): 2.82(lII,br). 3.15(lH,q), 3.27-3.60(8Iϊ.br).3.79(2H,d ) , 4.35(2II.d). 7.25(5H,m) EXAMPLE 73 Preparation of (R)-3-N-Methylcarbamoyl-2-(p- methoxyphenyl) propanol A well dried 1,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 500 ml of methanol was poured into the flask. 56.3 g of (R)-3-N-methylcarbamoyl-2-(p-methoxyphenyI ) propanol acetate prepared in Example 66 was well dissolved in the solvent and made to be homogeneous by stirring for 30 min. While being maintained at O ' C, the homogeneous solution was slowly added with 3.9 g of potassium cyanide. The resulting reaction mixture was heated to room temperature with stirring. To determine when the reaction would be terminated, the reaction was under double monitering of thin layer chromatography and liquid chromatography. Roughl>, it took about 2 hours lo finish the reaction. After completion of the reaction, 200 ml of saturated ammonium chloride solution was added. Then, using a rotary evaporator, unreacted methanol was completely removed from the reaction solution. 200 ml of distilled water and 400 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, lo give a yellow liquid. This liquid obtained was added with 100 ml of toluene and stored in a refrigerator for 24 hrs, to produce 40.7 g of (R)-3-N -methylcarbamoy I- 2- (p- methoxy phenyl) propanol as a white solid. Yield 85% II-NMR(CDCL, 200MHz), ppm ): 2.39(3H.d), 2.51(111,0, 3.24(lH,q ) , 3.75-4.05(4II,br ) , 5.43(1 II.br ), 6.91 (2H,d), 7.20(2H.d ) EXAMPLE 74 Preparation of (S )-3-Carbamoyl-2-phenyl propanol sulfamate A well dried 2,000 ml flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 1,200 ml of purified acetonitrile was poured into the flask. 58.5 g of (R)-3-carbamoyl-2-phenyl propanol prepared in Example 67 and 156.8 ml of diisopropyl ethylamine were well dissolved in the solvent and made to be homogeneous by stirring for 30 min. While being maintained at 0 * , the homogeneous solution was slowly added with 69.3 g of sulfamoyl chloride (prepared in the method described in Chem. Ber., 91. 1339-1341 (1958). to Appel and Berger). Al the same temperature, the reaction was proceeded and its progress was monitored by thin layer chromatography and liquid chromatography. Roughly, it took about 2 hours lo finish the reaction. After completion of the reaction, unreacted acetonitrile was completely removed from the reaction solution using a rotary evaporator. Then, 600 ml of distilled water and 600 ml of ethyl acetate were added for solvent extraction. The organic layer thus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotary evaporator, to give a yellow liquid. This liquid obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to obtain 76.5 g of (S)-3-carbamoyl-2-phenyl propanol sulfamates a white solid. Yield 93% H-NMR(ϋMSO. 200MHz), pp ): 3.35(lII,q), 4.16(2H,d). 4.34(2H,d).6.57(2II.br). 7.39(5H.s). 7.58(2H,s) EXAMPLE 75 Preparation of (S )-3-N-Melhylcarbamoyl-2-phenyl propanol sulfamate Except for using (R ) -3-N-methylcarbamoyl~2-phenyl propanol. instead of (R)-3-carbamoy!-2-phenyl propanol, as the starting material, the same procedure with that of Example 74 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetale/n-hexane (LI ) as a mobile phase, to obtain 77.8 g of (S)-3-N-methylcarbamoyl-2-phenyl propanol sulfamate as a white solid. Yield 90% II-NMR(DMSO, 200MHz ) , ppmU ) : 2.54(3Il.d), 3.35(lII,q), 4.29(4II.m), 6.98(1 II.br). 7.29(511, s). 7.53(2II,s) 5 EXAMPLE 76 Preparation of (S ) -3-N,N '-Dimelhylcarbamoyl-2- phenyl propanol sulfamate 0 Except for using (R ) -3-N,N'-dimethylcarbamoyl-2- phenyl propanol. instead of (R ) -3-carbamoy|-2-phenyl propanol, as the starling material, the same procedure with that of Example 74 was repeated. C A concentrated reaction mixture thus obtained was o separated by column chromatography using a mixlure of ethyl acetate/n-hexane (LI) as a mobile phase, lo obtain 79.7 g of (S)-3-N,N'-dimethylcarbamoyl-2-phenyl propanol sulfamate as a white solid. 0 Yield 88% H-NMR(CDCL, 200MIIz). ppmU ): 2.84(6II.d). 3.38(lH,q). 4.39(4II.m), 4.93(2II.s). 7.2l(5H.d ) EXAMPLE 77 Preparation of (S ) -3-N-lsopropyl carbamoyl-2-phen\ I propanol sulfamate Except for using (R)-3-N-isopropy I carbamoyl-2-phenyl propanol, instead of (R ) -3-carbamoyl- 2-phenyl propanol, as the starling material, the same procedure with that of Example 74 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixlure of ethyl acetate/n-hexane (LI ) as a mobile phase, to obtain 84.3 g of (S ) -3-N-isopropyl carbamoyl-2-phenyl propanol sulfamate as a white solid. Yield 89% H-NMR(DMSO, 200MIIz), ppmU ) : 1.01(6II.m), 3.32(lH,m). 3.55(lII.q), 4.18(2II.d). 4.29(2II.d). 6.95(lII,d>. 7.34(5II,s ) , 7.56(211. s) EXAMPLE 78 Preparation of (S)-3-N -Cyclopropyl carbamoyl-2- phenyl propanol sulfamate Except for using (R ) -3-N-cyclopropyl carbamoyl-2- phenyl propanol, instead of (R)-3-carbamoyl-2-phenyl propanol, as the starting material, the same procedure with that of Example 74 was repeated. A concentrated reaction mixture thus obtained was separated by column chromatography using a mixture of ethyl acetale/n-hexane (LI ) as a mobile phase, to produce 86.7 g of (R ) -3-K-cyclopropyl carbamoyl-2-phenyl propanol sulfamate as a while solid. Yield 92% H-NMR(DMSO, 200MIIz ) ppm(<5 ): 0.35-0.58(4Il.m ). 2.51 (III, s ) . 3.35(lII.q ) . 4.16-4.36(4II.m). 7.1 δ( 1 II .br). 7.29(5II,s). 7.52(2II,s) EXAMPLE 79 Preparation of ( S ) -3-N-Morphoryl carbamoyl-2-phen l 10 propanol sulfamate Except for using (R ) -3-N-morphoryl carbamoyl-2- phenyl propanol, instead of (R ) -3-carbamoyl-2-phenyl ,,- propanol. as the starting material, the same procedure with that of Example 74 was repeated. The liquid thus obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (1:1) as a mobile phase, to produce 94 g of 0 (S)-3-N-morphorylcarbamoyl-2-phenyl propanol sulfamate as a white solid. Yield 91% II-NMIKDMSO, 200MHz) ppmU ) : 3.05(lll.q) 3.20-3.50(8II.br), 4.15(4II.m). 4.43(2II,s ) . 7.13(5Il.m) 5 EXAMPLE 80 Preparation of (S ) -3-N-Melhylcarbamoyl-2-(p- methoxy |)henyl) propanol sulfamate A well dried 2,000 mi flask equipped with a thermometer was purged with nitrogen gas, to completely take off moisture and air from the inside of the flask. This purging was continued for 30 min, after which 1,200 ml of purified acetonitrile was poured into the flask. 71.8 g of (R)-3-N-melhylcarbamoyl-2-(p-methoxyphenyl) propanol prepared in Example 73 and 156.8 ml of diisopropyl ethylamine were well dissolved in the solvent and made to be homogeneous by stirring for 30 min. While being maintained at 0 ' C, the homogeneous solution was slowly added with 69.3 g of sulfamoyl chloride (prepared in the method described in Chem. Ber., 91, 1339-1341 (1958), to Appel and Berger). At the same temperature, the reaction was proceeded and its progress was monitored by thin layer chromatography and liquid chromatography. Roughly, il took about 2 hours to finish the reaction. After completion of the reaction, acetonitrile remaining was completely removed from the reaction mixture by using a rotary evaporator. 600 ml of distilled water and 600 ml of ethyl acetate were added for solvent extraction. The organic layer Ihus obtained was dried over anhydrous magnesium sulfate and distilled off the solvent by a rotarv evaporator, to give a yellow liquid. This liquid obtained was separated by column chromatography using a mixture of ethyl acetate/n-hexane (LI) as a mobile phase, to produce 84 g of (S)-3-N-methylcarbamoyl-2- ( p-methoxyphenyl) propanol sulfamate as a white solid. Yield 88% II-NMR(DMSO, 200 MHz), ppm ( δ ): 2.45(3II,d). 3.31(lII,q ) . 4.35(4IT.m ) . 6.48(1 II.br ) .6.89(2II,d). 7.49(2II.s) The compounds according to the present invention are very useful for the prophylaxis and treatment of CNS disorder, for example, nervous myalgia, epilepsy and minimal brain dysfunction. The present invention has been described in an illustrative manner, and it is to be understood the terminology used is intended to be in the nature of description rather than of limitation. Many modifications and variations of the present invention are possible in light of the above teachings. Therefore, il is to be understood that within the scope of the appended claims, the invention may be practiced otherwise than s specifically described.

Claims: WHAT IS CLAIMED IS: 1. N,N '-substituted carbamoyl-2-aryl propanol sulfamate racemates, represented by the following formula L wherein, Ar is represented by the following formulas; Y i selected from the group consisting of halogens such as F, Cl. Br and I, trifluoromethyl and alkyl groups containing 1 lo 3 carbon atoms when Y alone binds to benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 lo 3 carbon atoms when Y binds to X which is O or S; and Ri, and R ι. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 to 16 carbon atoms, cyclic alkyl groups containing 3 to 16 carbon atoms and aryl groups containing 6 to 8 carbon atoms, and NRιR> and NR:ιRι, identical or different, each may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom. 2. (R ) -N.K '-substituted carbamoyl-2-aryl propanol sulfamates, represented by the following formula IL (11 ) wherein, Ar is represented by the following formulas: Y is selected from the group consisting of halogens such as F, Cl. Br and 1, trifluoromethyl and alkvl groups containing 1 to 3 carbon atoms when Y alone binds to benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 to 3 cabon atoms when Y binds to X which is 0 or S; and Ri, R2. R:; and R.i, identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 to 16 carbon atoms, cyclic alkyl groups containing 3 lo 16 carbon atoms and aryl groups containing 6 to 8 carbon atoms, and NRιR> and NR3R1. identical or different, each may form a 3 lo 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom. 3. (S ) -N,N '-substituted carbamoyl-2-aryl propanol sulfamates, represented by the following formula III: (III) wherein, Ar is represented by the following formulas: Y is selected from the group consisting of halogens such as F, Cl. Br and 1. trifluoromethyl and alkyl groups containing 1 lo 3 carbon atoms when Y alone binds to benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 to 3 cabon atoms when Y binds to X which is O or S; and Ri, R>, R.; and R 1. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 to 16 carbon atoms, cyclic alkyl groups containing 3 lo 16 carbon atoms and aryl groups containing 6 lo 8 carbon atoms, and NRiR- and NR3R1, identical or different, each may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom. 4. 3-N-substituted carbamoyl-2-aryl propanol acetate, represented by the following formula IV: (IV) wherein, Ar is represented by the following formulas; Y is selected from the group consisting of halogens such as F, Cl. Br and 1, trifluoromethyl and alkyl groups containing 1 to 3 carbon atoms when Y alone binds lo benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 to 3 cabon atoms when Y binds to X which is O or S; and Ri and R • >. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 lo 16 carbon atoms, cyclic alkyl groups containing 3 to 1(5 carbon atoms and aryl groups containing 6 to 8 carbon atoms, and NRιR : ; may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom. 5. 3-N -substituted carbamoyl-2-aryl propanol, represented by the following formula V: |R 2 (V) wherein, Ar is represented by the following formulas; Y is selected from the group consisting of halogens such as F, Cl, Br and I, trifluoromethyl and alkyl groups containing 1 to 3 carbon atoms when Y alone binds to benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 lo 3 cabon atoms when Y binds to X which is O or S; and Ri, and R ■ >. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 to 16 carbon atoms, cyclic alkyl groups containing 3 to 16 carbon atoms and aryl groups containing 6 to 8 carbon atoms, and NRιR: may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom. 6. 3-Aceloxy-2-aryl propanol sulfamate, represented by the following formula VL (VI) wherein, Ar is represenled by the following formulas; Y is selected from the group consisting of halogens such as F, Cl. Br and I, trifluoromethyl and alkyl groups containing 1 to 3 carbon atoms when Y alone binds 10 benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 to 3 cabon atoms when Y binds to X which is O or S; and and R 1. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 to 16 carbon atoms, cyclic alkyl groups containing 3 to 1(5 carbon atoms and aryl groups containing lOfi 6 to 8 carbon atoms, and NR3R1 may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom. 7. 2-Aryl- 1.3-propandiol monosulfamate, represented by the following formula VII: (VII) wherein, Ar is represented by the following formulas; Y is selected from the group consisting of halogens such as F, Cl, Br and I. trifluoromethyl and alkyl groups containing 1 to 3 carbon atoms when Y alone binds to benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 lo 3 cabon atoms when Y binds to X which is O or S; and R3 and R 1. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 lo 16 carbon atoms, cyclic alkyl groups containing 3 to 16 carbon atoms and aryl groups containing 6 to 8 carbon atoms, and NR:;Rι may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom. 8. (S ) -3-N-sυbstituled carbamoyl-2-aryl propanol acetate, represented by the following formula VIIL (VIII) wherein, Ar is represented by the following formulas; Y is selected from the group consisting of halogens such as F, Cl. Br and 1, trifluoromethyl and alkyl groups containing 1 to 3 carbon atoms when Y alone binds lo benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 to 3 cabon atoms when Y binds to X which is O or S; and Ri and R>. identical or different, each are selected from the group consisting of hydrogen, linear or branched alk l groups containing 1 lo 16 carbon atoms, cyclic alkyl groups containing 3 to 16 carbon atoms and aryl groups containing 6 to 8 carbon atoms, and NRiR- may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom, with the proviso that Ri and Ra are not a hydrogen atom simultaneously. 9. (S)-3-N-substituted carbamoyl-2-aryl propanol, represented by the following formula IX: (IX) wherein, Ar is represented by the following formulas; Y is selected from the group consisting of halogens such as F, Cl, Br and I, trifluoromethyl and alkyl groups containing 1 to 3 carbon atoms when Y alone binds to benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 to 3 cabon atoms when Y binds lo X which is O or S; and Ri and R>. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 lo 16 carbon atoms, cyclic alkyl groups containing 3 lo 1(5 carbon atoms and aryl groups containing 6 to 8 carbon atoms, and NRιR> may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom, with the proviso that Ri and R>. are not a hydrogen atom simultaneously. 10. (S ) -3-acetoxy-2-aryl-1.3-propandiol sulfamate, represented by the following formula X: (X ) wherein, Ar is represented by the following formulas; Y is selected from the group consisting of halogens such as F, Cl, Br and I, trifluoromethyl and alkyl groups containing 1 to 3 carbon atoms when Y alone binds to benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 to 3 cabon atoms when Y binds lo X which is O or S; and R.i and R 1. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 10 16 carbon atoms, cyclic alkyl groups containing 3 to 1(5 carbon atoms and aryl groups containing 6 to 8 carbon aloms, and NR.sRi may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom. 11. (S ) -2-aryl-l,3-propandiol monosulfamate, represented by the following formula XL R 3 R 4 (XI) wherein, Ar is represented by the following formulas: Y is selected from the group consisting of halogens such as F, Cl, Br and 1, trifluoromethyl and alkyl groups containing 1 to 3 carbon aloms when Y alone binds to benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 lo 3 cabon atoms when Y binds to X which is O or S; and Ro and Ri identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 to 1(5 carbon atoms, cyclic alkyl groups containing 3 to 1(5 carbon atoms and aryl groups containing 6 to 8 carbon atoms, and NR3R1 may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom. 12. (R ) -3-N-substiluted carbamoyl-2-aryl propanol acetate, represented by the following formula XIL (XII) wherein, Ar is represented by the following formulas; Y is selected from Ihe group consisting of halogens such as F, Cl. Br and 1, trifluoromethyl and alkyl groups containing 1 to 3 carbon aloms when Y alone binds to benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 lo 3 cabon atoms when Y binds to X which is 0 or S; and Ri and identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 to 16 carbon aloms, cyclic alkyl groups containing 3 to 16 carbon atoms and aryl groups containing 6 to 8 carbon atoms, and NRιIL> may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom, with the proviso lhat Ri and R2 are not a hydrogen atom simultaneously. 13. (R ) -3-N-subslituted carbamoyl-2-aryl propanol, represented by the following formula XIIL (XIII) wherein, Ar is represented by the following formulas; Y is selected from the group consisting of halogens such as F, Cl, Br and 1, trifluoromethyl and alkyl groups containing 1 to 3 carbon aloms when Y alone binds lo benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 to 3 cabon atoms when Y binds lo X which is O or S; and Ri and R>. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkvl groups containing 1 to 16 carbon atoms, cyclic alkyl groups containing 3 to 1(5 carbon aloms and aryl groups containing 6 to 8 carbon atoms, and NRιR> may form a 3 lo 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen alom. with the proviso that Ri and R2 are not a hydrogen atom simultaneously. 14. A method for preparing an N,N' -substituted carbamoyl-2-aryl propanol sulfamate racemate, represented by the following formula I, which comprises reacting 3-acetoxy-2-aryl propanol, represented by the following formula XIV, with carbonyl diimidazole to give 3-imidazolyl carbonyloxy-2-aryl propanol acetate, represented by the following formula XV, reacting the 3-imidazolyl carbonyloxy-2-aryl propanol acetate with a substituted amine, represented by the following formula XVI, to give a 3-N-substituted carbamoyl-2-aryl propanol acetate, represented by the following formula IV, subjecting the 3-N-substituted carbamoyl-2-aryl propanol acetate lo transesterification in an alcohol solvent in the presence of a base catalyst, lo produce a 3-N-substiluted carbamoyl-2-aryI propanol, represented by the following formula V, and reacting the 3-N-subsiituted carbamoyl-2-aryl propanol with sulfamoyl chloride: (XIV) (XV) HNR,R, (XVI) 15 20 (IV) (V) 113 (I) wherein, Ar is represented by the following formulas; Y is selected from the group consisting of halogens such as F, Cl, Br and I, trifluoromethyl and alkyl groups containing 1 to 3 carbon atoms when Y alone binds to benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 to 3 cabon atoms when Y binds to X which is O or S; and Ri, R?, R., and R i. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 to 16 carbon aloms, cyclic alkyl groups containing 3 lo 16 carbon atoms and arvl groups containing 6 lo 8 carbon atoms, and NRiR- and NR3R , identical or different, each may form a 3 lo 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom. 15. The method in accordance with claim 14, wherein lift the compound of Formula XIV is reacted al an amount of about 0.1 to 2.0 moles with 1.1 to 2.5 equivalents of carbonyl diimidazole. 16. The method in accordance with claim 14. wherein the compound of Formula XIV is reacted at a temperature of -5 to 40°C lo give the compound of Formula XV. 17. The method in accordance with claim 14, wherein the compound of Formula XIV is reacted in a solvent selected from the group consisting of low hydrocarbon halide solvents including methylene chloride and chloroform, ethereal solvents including ethyl ether and tetrahydrofuran, and acetonitrile, to give the compound of Formula XV. 18. The method in accordance with claim 14, wherein the substituted amine of Formula XVI is used at an amount of 1.0 to 5.0 equivalents. 19. The method in accordance with claim 14, wherein the compound of Formula XV is reacted at a temperfiture of 0 to 30 C C in a solvent such as tetrahydrofuran and methylene chloride, lo produce the compound of Formula IV. 20. The method in accordance with claim 14, wherein the compound of Formula IV is used at an amount of about 0.1 to 2.0 moles. 21. The method in accordance with claim 14, wherein said base catalyst is selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium carbonate, lithium hydroxide, potassium carbonate, sodium bicarbonate and potassium cyanide and is used at an amount of 0.1 to 1.0 equivalent. 22. The method in accordance with claim 14, wherein the compound of Formula IV is reacted at a temperature of 0 to 30 * C , to produce the compound of Formula V. 23. The method in accordance with claim 14. wherein said alcohol solvent is selected from the group consisting of methyl alcohol, ethyl alcohol and propyl alcohol. 24. The method in accordance with claim 14, further comprising the step of inactivating said base catalyst by addition of IN aqueous hydrochloric acid or saturated ammonium chloride solution after the completion of said transesterification. 25. The method in accordance with claim 14, wherein the compound of Formula V is reacted at an amount of 0.1 to 2.0 moles with 1.5 to 3.0 equivalents of sulfamoyl chloride. 26. The method in accordance with claim 14. wherein the compound of Formula V is reacted in the presence of a base catalyst, lo prepare the compound of Formula I. said base catalyst being selected from the group consisting of triethyl amine. pyridine, antipyrin and diisopropylelhvl amine and used at an amount of 2.0 to 4.0 equivalents. 27. The method in accordance with claim 14, wherein the compound of Formula V is reacted in a solvent selected from the group consisting of amide solvents including dimethylform amide, ethereal solvents including ethyl ether and tetrahydrofuran, and acetonitrile. to prepare the compound of Formula I. 28. The method in accordance with claim 14, wherein the compound of Formula V is reacted al a temperature of -10 to 40'C, to prepare the compound of Formula 1. 29. A melhod for preparing an N,N' -substituted carbamoyI-2-aryl propanol sulfamate, represented by ihe following formula I, which comprises reacting 3-acetoxy-2-arv I propanol, represented by the following formula XIV, with sulfamoyl chloride in the presence of a base catalyst, to produce a 3-acetoxy-2-aryl propanol sulfamate, represented by following formula VI, subjecting the 3-acetoxy-2-aryl propanol sulfamate to transesterification in an alcohol solvent in the presence of a base catalyst. to produce a 2-aryl-l,3-propandiol monosulfamate, represented by the following formula VII. reacting the -aryl- 1,3-propandiol monosulfamate with carbonyl diimidazole to give a 3-imidazolyl carbonyloxy-2-aryl propanol sulfamate, represented by the following formula XVII, and substituting the imidazole group of the 3-imidazolyl carbonyloxy-2-aryl propanol sulfamate with a substituted amine, represented by the following formula XVL (XIV) (VI ) (VII) (XVII) IINR.R (XVI) A (I) wherein, Ar is represented by the following formulas; Y is selected from the group consisting of halogens such as F, Cl. Br and I, trifluoromethyl and alkvl groups containing 1 to 3 carbon atoms when Y alone binds to benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 to 3 cabon atoms when Y binds lo X which is O or S; and Ri, Ri, R:ι and Ri. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 to 16 carbon atoms, cyclic alkyl groups containing 3 to 16 carbon atoms and aryl groups containing 6 lo 8 carbon aloms, and NRiR- and NR3R1. identical or different, each may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom. 30. The method in accordance with claim 29. wherein the compound of Formula XIV is reacted at an amount of about 0.1 to 2.0 moles with 1.5 to 3.0 equivalents of sulfamoyl chloride. 31. The method in accordance with claim 29, wherein said base catalyst for the production of the compound of Formula VI from the compound of Formula XIV is selected from the group consisting of iriethyl amine, pyridine, antipyrin and diisopropylelhvl amine and used at an amount of 2.0 to 4.0 equivalents. 32. The method in accordance with claim 29. wherein the compound of Formula XIV is reacted in a solvent selected from the group consisting of amide solvents including dimethyl formamide, ethereal solvents including ethyl ether and tetrahydrofuran, and acetonitrile, to give the compound of Formula VI. 33. The method in accordance with claim 29, wherein the compound of Formula XIV is reacted at a temperature of -10 lo 40'C to give the compound of Formula VI. 34. The method in accordance with claim 29, wherein the compound of Formula VI is used at an amount of about 0.1 to 2.0 moles. 35. The method in accordance with claim 29, wherein the base catalyst for the production of the compound of Formula VII from the compound of Formula VI is selected from the group consisting of sodium hydroxide, potassium hydroxide, lithium hydroxide, potassium carbonate, sodium bicarbonate and potassium cyanide and used at an amount of 0.1 to 1.0 equivalent. 36. The method in accordance with claim 29, wherein the compound of Formula VI is reacted at a temperature of 0 to 30"C to produce the compound of Formula VII. 37. The method in accordance with claim 29, wherein said alcohol solvent for the transesterification of the compound of Formula VI into the compound of Formula VII is selected from the group consisting of methyl alcohol, ethyl alcohol and prop l alcohol. 38. The method in accordance with claim 29, further comprising the step of inactivating said base catalyst by addition of IN aqueous hydrochloric acid or saturated ammonium chloride solution after the completion of said transesterification. 39. The method in accordance with claim 29, wherein the compound of Formula VII is reacted at an amount of about 0.1 to 2.0 moles with 1.1 to 2.5 equivalents of carbonyl diimidazole. 40. The method in accordance with claim 29, wherein the compound of Formula VII is reacted at a temperature of -5 to 40'C to produce the compound of Formula XVII. 41. The method in accordance with claim 29, wherein the compound of Formula VII is reacted in a solvent selected from the group consisting of low hydrocarbon halide solvents including methylene chloride and chloroform, ethereal solvents including ethyl ether and tetrahydrofuran, and acetonitrile, to produce the compound of XV 11. 42. The method in accordance with claim 29. wherein said substituted amine is used at an amount of 1.0 to 5.0 equivalents to produce the compound of Formula 1 from the compound of Formula XVII. 43. The method in accordance with claim 29, wherein the compound of Formula XVII is reacted at a temperature of 0 to 30 ° C to produce the compound of Formula 1. 44. The method in accordance with claim 29. wherein the compound of Formula XVII is reacted in a solvent such as tetrahydrofuran and methylene chloride. 45. A method for preparing an N.N' -substituted carbamoyl-2-aryl- 1.3-propandiol sulfamate. represented by the following formula I, which comprises reading a 2-aryl-l,3-propandiol monosulfamate represented by the following formula VII, with an isocyanate represented by the following formula XV1IL (VII) RiNCO (XVIII) (I ) wherein, Ar is represented by the following formulas: Y is selected from the group consisting of halogens such as F, Cl, Br and 1, trifluoromethyl and alkyl groups containing 1 to 3 carbon atoms when Y alone binds to benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 to 3 cabon atoms when Y binds to X which is O or S; and Ri, R3 and R 1. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 to 16 carbon atoms, cyclic alkyl I2fi groups containing 3 to 16 carbon atoms and aryl groups containing 6 to 8 carbon atoms, and NR3R1 may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom. 46. The method in accordance with claim 45, wherein the compound of Formula VII is reacted at an amount of 0.1 to 2.0 moles with 1.0 to 2.0 equivalents of the compound of Formula XVIII. 10 47. The method in accordance with claim 45, wherein the compound of Formula VII is reacted at a temperature of 0 to 80'C. 15 48. The method in accordance with claim 45, wherein the compound of Formula VII is reacted in a solvent selected from the group consisting of low hydrocarbon halide solvents including methylene chloride and chloroform, 20 ethereal solvents including ethyl ether and tetrahydrofuran, and aromatic hydrocarbons including benzene and toluene. 49. A method for preparing an (R ) -N.N'-substituled carbamoyl-2-aryl propanol sulfamate, represented by the ^ following formula II. which comprises reading (R)-3-acetoxy-2-arv propanol. represented by the following formula XIX, with carbonyl diimidazole lo give an (S)-3-imidazolyl carbonyloxy-2-aryl propanol acetate, represented by the following formula XX, substituting the imidazole group of the (S ) -3-imidazolyl carbonyloxy-2-aryl propanol acetate with a substituted amine, represented by the following formula XVI. to give an (S ) -3-N- substituted carbamoyl-2-aryl propanol acetate, represented by the following formula VIII, subjecting the (S ) -3-N-subslituled carbamoyl-2-aryl propanol acetate lo transesterification in an alcohol solvent in the presence of a base catalyst, to produce an (S)-3-N-subsiituted carbamoyl-2-aryl propanol, represented by the following formula IX, and reacting the (S)-3-N-substituled carbamoyl-2-aryl propanol with sulfamovl chloride: 3 (XIX) (XX) IΪNRiR (XVI) (VIII) (IX) (II) wherein, Ar is represented by the following formulas; Y is selected from the group consisting of halogens such as F. Cl. Br and 1, trifluoromethyl and alkvl groups containing 1 to 3 carbon aloms when Y alone binds to 12!) benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 to 3 cabon atoms when Y binds to X which is O or S; and Ri. R , R:; and R ι. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 lo 16 carbon atoms. cyclic alkyl groups containing 3 to 16 carbon atoms and aryl groups containing (5 lo 8 carbon atoms, and NRiR- and NR3R1, identical or different, each may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom. 50. The method in accordance with claim 49, wherein the compound of Formula XIX is reacted at an amount of about 0.1 to 2.0 moles with 1.1 to 2.5 equivalents of carbonyl diimidazole. 51. The method in accordance with claim 49, wherein the compound of Formula XIX is reacted at a temperature of -5 to 40'C to give the compound of Formula XX. 52. The method in accordance with claim 49, wherein the compound of Formula XIX is reacted in a solvent selected from the group consisting of low hydrocarbon halide solvents including methylene chloride and chloroform, 1H0 ethereal solvents including ethyl ether and tetrahydrofuran, and acetonitrile, lo give the compound of Formula XX. 53. The method in accordance with claim 49, wherein the substituted amine of Formula XVI is used at an amount of 1.0 to 5.0 equivalents. 54. The method in accordance with claim 49, wherein the compound of Formula XX is reacted at a temperature of 10 0 to 30T in a solvent such as tetrahydrofuran and methylene chloride, lo produce the compound of Formula VIII. ιcr 55. The method in accordance with claim 49, wherein lo the compound of Formula VIII is used at an amount of about 0.1 to 2.0 moles. 56. The method in accordance with claim 49, wherein 20 said base catalyst is selected from the group consisting of sodium hydroxide, potassium hydroxide, lithium hydroxide, potassium carbonate, and potassium cyanide and is used al an amount of 0.1 to 1.0 equivalent. 25 57. The method in accordance with claim 49. wherein the compound of Formula VIII is reacted at a temperature of 0 to 30'C, to produce the compound of Formula IX. 58. The method in accordance with claim 49. wherein said alcohol solvent is selected from the group consisting of methyl alcohol, ethyl alcohol and propyl alcohol. 59. The method in accordance with claim 49, further comprising the step of inactivating said base catalyst by addition of IN aqueous hydrochloric acid or saturated 0 ammonium chloride solution after the completion of said transesterification. 60. The method in accordance with claim 49, wherein r the compound of Formula IX is reacted at an amount of O.l o to 2.0 moles with l .0 to 3.0 equivalents of sulfamo l chloride. 61. The method in accordance with claim 49, wherein 0 the compound of Formula IX is reacted in the presence of a base catalyst, to prepare the compound of Formula 11, said base catalyst being selected from the group consisting of triethvl amine, pyridine, antipyrin and diisopropylelhvl amine and used at an amount of 2.0 lo 4.0 equivalents. 62. The method in accordance with claim 49, wherein the compound of Formula IX is reacted in a solvent selected from the group consisting of amide solvents including dimethylform amide, ethereal solvents including ethyl ether and tetrahydrofuran, and acetonitrile, to prepare the compound of Formula II. 63. The method in accordance with claim 49, wherein the compound of Formula IX is reacted at a temperature of -10 to 40°C, to prepare the compound of Formula II. 0 64. A method for preparing an (S)-N,N '-substituted carbamoyl-2-aryl propanol sulfamate, represented by the following formula 111, which comprises reacting an r - (R)-3-acetoxv-2-arvl propanol, represented bv the following 5 formula XIX, with sulfamoyl chloride in the presence of a base catalyst, to produce an (S ) -3-acetoxy-2-aryl- 1,3-propandiol sulfamate, represented by following formula X, subjecting the (S ) -3-acetoxy-2-aryl-l,3-propandiol 0 sulfamate lo transesterification in an alcohol solvent in the presence of a base catalyst, to produce an (S)-2-aryl-l,3-propandiol monosulfamate, represented by the following formula XI. reading the (S ) -2-aryl-l,3-propandiol monosulfamate with carbonyl diimidazole to give an 5 (S)-3-imidazolyl carbonyloxy-2-aryl propanol sulfamate. represented by the following formula XXI, and substituting the imidazole group of the (S ) -3-imidazolyl carbonyloxy-2-aryl propanol sulfamate with a substituted amine. represented by the following formula XVL (XIX) (X ) (XI ) ( XXI ) IINRiRa (XVI) (III ) wherein, Ar is represented by the following formulas; Y is selected from the group consisting of halogens such as F, Cl, Br and I, trifluoromethyl and alkyl groups containing 1 to 3 carbon aloms when Y alone binds to benzene ring and from Ihe group consisting of trifluoromethyl and alkyl groups containing 1 lo 3 cabon atoms when Y binds lo X which is O or S; and Ri, R . R.! and R i. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 to 16 carbon atoms, cyclic alkyl groups containing 3 lo 16 carbon aloms and aryl groups containing (5 lo 8 carbon atoms, and NRiR- and NR3R1, identical or different, each may form a 3 lo 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom. 65. The method in accordance with claim 64. wherein the compound of Formula XIX is used at an amount of about 0.1 lo 2.0 moles. 66. The meihod in accordance with claim 64. wherein said base catalyst for the production of the compound of Formula X from the compound of Formula XIX is selected from the group consisting of triethyl amine, pyridine, antipyrin and diisopropv lelhyl amine and used al an amount of 2.0 to 4.0 equivalents. 67. The meihod in accordance with claim 64. wherein the compound of Formula XIX is reacted in a solvent selected from Ihe group consisting of amide solvents including dimethyl formamide, ethereal solvents including ethyl ether and tetrahydrofuran, and acetonitrile, lo give the compound of Formula X. 68. The method in accordance with claim 64. wherein the compound of Formula XIX is reacted at a temperature of -10 to 40 ' C to give the compound of Formula X. 69. The method in accordance with claim (54, wherein the compound of Formula X is used at an amount of about 0.1 to 2.0 moles 70. The method in accordance with claim 64, wherein the base catalyst for the production of the compound of Formula XI from the compound of Formula X is selected from the group consisting of sodium hydroxide, potassium hydroxide, lithium hydroxide, potassium carbonate and potassium cyanide and used at an amount of 0.1 to 1.0 equivalent. 71. The method in accordance with claim 64, wherein the compound of Formula X is reacted at a temperature of 0 to 30°C to produce the compound of Formula XL 72. The meihod in accordance with claim 64. wherein said alcohol solvent for the transesterification of the compound of Formula X inlo the compound of Formula XI is selected from the group consisting of methyl alcohol, ethyl alcohol and propyl alcohol. 73. The method in accordance with claim 64, further comprising the step of inactivating said base catalyst by addition of IN aqueous hydrochloric acid or saturated ammonium chloride solution after the completion of said transesterification. 74. The meihod in accordance with claim 64, vvherei the compound of Formula XI is reacted at an amount of about 0.1 to 2.0 moles with 1.1 to 2.5 equivalents of carbonyl diimidazole. 75. The meihod in accordance with claim (54, wherein the compound of Formula XI is reacted at a temperature of -5 to 40'C to produce the compound of Formula XXI. 76. The method in accordance with claim 64, wherein the compound of Formula XI is reacted in a solvent selected from the group consisting of low hydrocarbon halide solvents including methylene chloride and chloroform, ethereal solvents including ethyl ether and tetrahydrofuran, and acetonitrile. to produce the compound of XXL 77. The meihod in accordance with claim 64, wherein said substituted amine is used at an amount of 1.0 lo 5.0 equivalents to produce the compound of Formula 111 from the compound of Formula XXI. 78. The method in accordance with claim 64, wherein the compound of Formula XXI is reacted at a temperature of 0 to 30 'C. 79. The method in accordance with claim 64, wherein the compound of Formula XXI is reacted in a solvent such as tetrahydrofuran and methylene chloride. 80. A meihod for preparing an (S ) -N,N '-substituted carbamoyl-2-aryl propanol sulfamate, represented by the following formula III, which comprises reacting an (S)-3-acetoxy-2-arv I propanol, represented by the following formula XXII, with carbonyl diimidazole to give an (R)-3-imidazolv I carbonyloxy-2-aryl propanol acetate, represented by the following formula XXIII, substituting the imidazole group of the (R)-3-imidazolyl carbonyloxy-2-aryl propanol acetate with a substituted amine. represented by the following formula XVI. lo give an (R ) -3-N-substituted carbamoyl-2-arv I propanol acetate, represented by the following formula XII, subjecting the (R ) -3-N- substituted carbamoyl-2-arv I propanol acetate lo transesterification in an alcohol solvent in the presence of a base catalyst, to produce an (R )-3-N -substituted carbamoyl-2-aryl propanol. represented by the following formula XIII, and reacting the (R)-3-N-subslitιιled carbamoyl-2-aryl propanol with sulfamoyl chloride ' (XXII) (XXIIL IINRiR 15 (XVI) (XII ) ( XIII ) (III) wherein, Ar is represented by the following formulas; Y is selected from the group consisting of halogens such as F, Cl, Br and I, trifluoromethyl and alkyl groups containing 1 lo 3 carbon atoms when Y alone binds to benzene ring and from the group consisting of trifluoromethyl and alkyl groups containing 1 to 3 carbon atoms when Y binds lo X which is O or S; and Ri, R.!, IL; and R 1. identical or different, each are selected from the group consisting of hydrogen, linear or branched alkyl groups containing 1 to 16 carbon aloms. cyclic alkyl groups containing 3 lo 16 carbon atoms and arvl groups containing ( 5 to 8 carbon atoms, and NRιR> and NR3R.1, identical or different, each may form a 3 to 7-membered aliphatic cyclic compound together with another nitrogen atom or oxygen atom. 81. The meihod in accordance with claim 80. wherein the compound of Formula XX 11 is reacted at an amount of about 0.1 to 2.0 moles with 1.1 lo 2.5 equivalents of carbonyl diimidazole. 82. The meihod in accordance with claim 80, wherein the compound of Formula XXII is reacted at a temperature of -5 to 40 ' C lo give the compound of Formula XXIII. 83. The meihod in accordance with claim 80, wherein the compound of Formula XX11 is reacted in a solvent selected from the group consisting of low hydrocarbon halide solvents including methylene chloride and chloroform, ethereal solvents including ethyl ether and tetrahydrofuran, and acetonitrile, lo give the compound of Formula XX1I1. 84. The meihod in accordance with claim 80, wherein the substituted amine of Formula XVI is used at an amount of 1.0 to 5.0 equivalents. 85. The method in accordance with claim 80, wherein the compound of Formula XXIII is reacted at a temperature of 0 to 30 'C , to produce the compound of Formula XII. 86. The meihod in accordance with claim 80, wherein the compound of Formula XII is used at an amount of about 0.1 to 2.0 moles. 87. The method in accordance with claim 80, wherein said base catalyst is selected from the group consisting of sodium hydroxide, potassium hydroxide, lithium hydroxide, potassium carbonate and potassium cyanide and is used at an amount of 0.1 lo 1.0 equivalent. 88. The meihod in accordance with claim 80, wherein the compound of Formula XII is reacted at a temperature of 0 to 30 'C , to produce ihe compound of Formula X1I1. 89. The method in accordance with claim 80. wherein said alcohol solvent is selected from the group consisting of methyl alcohol, ethyl alcohol and propyl alcohol. 90. The method in accordance with claim 80, further comprising the step of inactivating said base catalyst by addition of IN aqueous hydrochloric acid or saturated ammonium chloride solution after the completion of said transesterification. 91. The method in accordance with claim 80, wherein the compound of Formula XIII is reacted at an amount of 0.1 to 2.0 moles with 1.0 lo 3.0 equivalents of sulfamoyl chloride. 92. The method in accordance with claim 80, wherein the compound of Formula Xlll is reacted in the presence of a base catalysl, to prepare the compound of Formula III, said base catalyst being selected from the group consisting of triethvl amine, pyridine, antipyrin and diisopropylethyl amine and used al an amount of 2.0 lo 4.0 equivalents. 93. The method in accordance with claim 80, wherein the compound of Formula XIII is reacted in a solvent selected from the group consisting of amide solvents including dimelhylform amide, ethereal solvents including ethyl ether and tetrahydrofuran, and acetonitrile, lo prepare the compound of Formula III.

Inventors: CHOI YONG MOON, HAN DONG IL, KIM HYUNG CHEOL, CHOI, YONG, MOON, HAN, DONG, IL, KIM, HYUNG, CHEOL
Applicants: YUKONG LTD, YUKONG LIMITED
Application year: 1996
Main classification: C07C307
IPC codes: A61K31, A61P25, C07B61, C07C271, C07C303, C07C307, C07D233, C07D295