Process for producing a medical device

Abstract: This invention provides a medical device in which its lubricity is continually maintained and its safety is guaranteed. Particularly, it provides a medical device in which lubricity is generated on at least a portion of its surface when the device is contacted with body fluids or exposed to physiological aqueous conditions, wherein the lubricity-generating portion is formed by thermoforming.

Description: FIELD OF THE INVENTION This invention relates to a process for producing a medical device in which lubricity is generated on its surface when the device is contacted with body fluids or exposed to physiological aqueous conditions. More particularly, it relates to a process for producing a medical device in which lubricity is generated on its surface when the device is contacted with body fluids or exposed to physiological aqueous conditions as a result of its insertion into the living body to carry out a medical treatment or a diagnosis. BACKGROUND OF THE INVENTION Tissue injuries such a mucosal injury, vascular injury and the like occur when general medical devices composed of plastics, metals, ceramics and the like are inserted into the living body and contacted strongly with biological tissues. In concrete terms, when a catheter, a guide wire, an endoscope, a rectal thermometer probe or the like is inserted into a blood vessel, a digestive organ or the like hollow organ until it reaches the intended position, various tissue injuries including mucosal injury and vascular injury occur which give patients pain and cause prolongation of therapeutic period. Also, in some cases, a medical device cannot be inserted into the intended position due to its large insertion resistance. In consequence, in order to lessen these injuries or reduce the insertion resistance, various measures have been taken in the prior art for example by using a low friction material as the base material, coating the device surface with oils which give lubricity or with a hydrophilic polymer or fixing a hydrophilic polymer to the surface making use of covalent bond, ionic bond and the like chemical bonds. Illustrative examples of the low friction material include polyethylene, polyacetal, fluorocarbon resin and the like, and those of the lubricity-providing oil include silicone oil, olive oil, glycerol and the like. With regard to the method for fixing a hydrophilic polymer to the material surface, JP-B-59-19582 discloses a method in which polyvinyl pyrrolidone or the like is fixed making use of isocyanate group (the term "JP-B" as used herein means an "examined Japanese patent publication"), JP-A-59-81341 discloses a method in which two or more hydrophilic polymers are fixed also making use of isocyanate group (the term "JP-A" as used herein means an "unexamined published Japanese patent application") and JP-A-58-193766 discloses a method in which polyethylene oxide is fixed also making use of isocyanate group. However, such low friction materials are not effective in sufficiently preventing tissue injuries, and continual presence of lubricity cannot be obtained by the method in which oils or hydrophilic polymers are used. Also, since a substance having high reactivity (isocyanate group or the like) is used in the fixation of a hydrophilic polymer to the surface, it is probable that the substance when remained will cause a problem due to its toxicity. In addition, when the method in which an oil or a hydrophilic polymer is used is employed in the production process of medical devices , the process becomes complex due, for example, to the increased number of operation steps. Thus, as has been described in the foregoing, the prior art methods for adding lubricity to the surface of a medical device have disadvantages in that production process of the device becomes complex, its lubricity cannot be maintained continually and when chemicals having high reactivity are used, its safety cannot be maintained depending on a situation. SUMMARY OF THE INVENTION In view of the above, it therefore becomes an object of the present invention to provide a medical device in which its effects are continually maintained and its safety is guaranteed by employing a method which is simpler than the conventional coating method. (1) In accordance with the present invention, there is provided a process for producing a medical device in which lubricity is generated on at least a portion of its surface when the device is contacted with body fluids or exposed to physiological aqueous conditions, wherein the improvement resides in that the lubricity-generating portion is formed by thermoforming. (2) At least a portion of the lubricity-generating portion arranged on at least a portion of the surface of the device is comprised of a compound (or a polymer) having a derivative of polyalkylene oxide. (3) There is provided the medical device wherein a chemical reaction takes place between a surface layer having the lubricity generating portion and a layer under thereof constituting the device while the device is formed under heating. Other objects and advantages of the present invention will be made apparent as the description progresses. BRIEF DESCRIPTION OF THE DRAWING Fig. 1 is a schematic illustration of a simulated blood vessel for use in the evaluation of lubricity of the medical device of the present invention, in which the character 1 represents the simulated blood vessel. DETAILED DESCRIPTION OF THE INVENTION Unlike the prior art materials prepared by coating or making use of a chemical bond-aided polymer reaction, the material to be used in at least a portion of the lubricity-generating portion of the present invention is a polyethylene oxide modified, by well known processes, at one end or both ends with such groups as amino, carboxyl, thiol. For example, such urethane or polyamide compounds having a polyethylene oxide derivative modified at one end or both ends with such groups as amino, carboxyl and thiol are expected to fortify the adhesive force on the surface of the medical device by the modified functional group in addition to the lubricating properties based on the polyalkylene main chain. Furthermore, when a substance expected to generate lubricity on the surface is composed of a material modified with such compounds having proton-reactive functional groups as maleic anhydride and glycydil (meth) acrylate, and when the substance generating lubricity on the surface is a modified polyethylene oxide having such proton-donating groups as amino, carboxyl and thiol, a chemical bonding is induced on the boundary during forming of the device under heating to result in strong adhesion providing a safer medical device. The material to be used in at least a portion of the lubricity-generating portion of the present invention is not necessarily a single material, and can be used by mixing it with other materials, particularly other resins. For example, a cross-linked or a derivative of polyalkylene oxide may be used suitably by mixing it with olefinic resins such as polyethylene, polypropylene, modified polyolefin and the like, as well as polystyrene, polyvinyl chloride, polycarbonate, acrylonitrile-butadiene-styrene copolymer, ethylenevinyl acetate copolymer, polyamide, polyethylene terephthalate and the like. Their mixing ratios are not particularly limited. Preferably the content of the lubricity generating materials (polymers) is 5 to 95 wt%, more preferably 20 to 80 wt%. The material to be used in at least a portion of the lubricity-generating portion of the present invention may be used suitably by mixing it with a radio opaque agent such as powder of tungsten, barium sulfate, bismuth oxycarbonate, sodium iodide. Their mixing ratio are not particularly limited, but preferably, the content of the radio opaque agent is up to 50 wt%, more preferably 20 to 45 wt%. In this embodiment, the medical device of the present invention has radio opaque properties as well as lubricating properties. Though the thermoforming of the present invention is not particularly limited, it may be effected preferably by extrusion molding, multilayer extrusion molding, profile extrusion molding, injection molding, multiple color injection molding, insert injection molding, press molding, vacuum press molding and the like means. Each of these thermoforming means is conventional molding method and does not require a special making machine or special molding techniques. That is, forming of a crystalline resin may be carried out at a temperature which is higher than its melting point by a factor of approximately 10 to 40°C, and an amorphous resin may be formed at a temperature which is higher than its glass transition point by a factor of approximately 80 to 150°C. A hollow shape product such as a catheter or the like may be formed by extrusion molding, or by co-extrusion molding together with a base material resin which forms inner layer when it is desirable to obtain lubricity only on the outermost surface of a catheter. The thermoforming can also be applied to a member which is formed by injection molding, such as a rectal thermometer probe. In order to add lubricity only to the outermost surface of said probe, two color (multiple color) injection molding or insert injection molding may be effective. Also, when a thin dish-like product is formed, press molding or vacuum press molding may be used. In addition, a press-molded product having lubricity only on its outermost surface can be obtained making use of a multi-layer sheet having a lubricity material on its surface prepared in advance by co-extrusion molding. Alternatively, two or more members molded in advance by thermoforming may be made into a composite structure making use of an adhesive resin, adhesive agent or the like. In comparison with the conventional materials obtained by a coating method or a chemical bond-aided polymer reaction, the lubricity-generating portion can be formed more thickly by each of these molding methods, so that its peeling does not occur during operation of a medical device and continual presence of its function can be expected. The medical device of the present invention is a device which is used by contacting it with body fluids such as blood, lymph, saliva, tears, gastric juice, urine and the like or with physiological aqueous systems such as physiological saline, ion concentration-adjusted buffer solutions and the like. Since its contact with these liquids generates lubricity on its surface, workability of said medical device, such as easy insertion into the aimed position, is improved and tissue injuries can be reduced. Though not particularly limited, the medical device of the present invention is used for medical treatment or diagnosis in the aforementioned manner, preferably as a catheter, a guide wire, an endoscope, a rectal thermometer probe. EXAMPLES (Inventive Example 1) A mixture of a modified polyethylene oxide (PAOGEN®, manufactured by Daiichi Kogyo Seiyaku and 45wt% of a fine tungsten powder (particle size ca.3-4 µm) as radio opaque agent were melted and kneaded to obtain a raw material containing a ratio opaque agent. PAOGEN: polyethylene oxide of molecular weight about 10000 is modified with polycarboxylic acid for chain extension to molecular weight of about 100000. A three layered tube was prepared by use of the raw material as the outer layer, a maleic anhydride-modified polyethylene (BONDINE® X8290, manufactured by Sumitomo Chemical) as the middle layer (adhesive layer) and a urethane (MiRACTRAN® P395, manufactured by Nippon Miractoran) as the inner layer. A catheter wire for shadow-forming of blood vessel was prepared by covering with the three-layered tube an inner core of a 51%Ni-Ti alloy having the length of 1800 mm, tip opening of 0.06 mm diameter, bottom opening of 0.25 mm diameter and a 120 mm tapered portion down to the tip opening. Thus obtained wire had the total length of 1800 mm and diameter of around 0.8 mm. A simulated blood vessel 1 of 1 mm in inner diameter which has been prepared from polyvinyl chloride and filled with physiological saline was made into a loop-like shape of 50 mm in radius (see Fig. 1), and the catheter tube obtained above was inserted into the thus prepared blood vessel (insertion length, 500 mm; insertion rate, 50 mm/min; 37°C) to measure the value of resistance with a tensile tester. The results are shown in Table 1. When insertion and ejection of the tube were repeated 100 times, peeling was not observed and its lubricity was maintained. Also, an eluting material test by a "disposable arteriovenous indwelling catheter" (Manual on Standards and Criteria of Medical Tools, pp.271 - 273, 1991, published by Yakugyo Jiho-sha) was carried out, with the results also shown in table 1. Material name Molding method Value of resistance (gf) Eluting material test Inventive Example 1 Modified polyethylene oxide/maleic anhydride-modified polyethylene/urethane Extrusion molding 24 Acceptable Comparative Example 1 Maleic anhydride-modified polyethylene/urethane Extrusion molding 185 - The 100 times insertion and ejection of the wire showed no remarkable increase in the peeling and resistance, and the lubricity was maintained. Further, the eluting material test was conducted in the manner as disclosed shows that the result was acceptable (see table 1) . (Comparative Example 1) Without using the modified polyethylene oxide of Inventive Example 1 (PAOGEN® , manufactured by Daiichi Kogyo Seiyaku), the tungsten fine powder and a maleic anhydride-modified polyethylene (BONDINE® HX8290, manufactured by Sumitomo Chemical) were melted and kneaded to obtain a raw material containing a radio opaque agent. By use of the raw material for the outer layer, a catheter for radio opaque of blood vessel was prepared. Resistance to the insertion and ejection of the wire were measured similarly, and the result is shown in table 1. (Inventive Example 2) By a multi-layered blow molding method, were obtained gloves for touch of anus having a styrene elastomer (RABALON® ME6301, manufactured by Mitsubishi Petrochemical) as the inner layer, a maleic anhydride-modified polyethylene (MODIC® E-200H, manufactured by Mitsubishi Petrochemical) as the middle layer and a terminally aminated polyethylene oxide (PEO amine # 6000, manufactured by Kawaken Finechemical) as the inner layer. Though the glove showed no lubricity on the dry surface, however, the surface lubricity generated so well when wetted with physiological saline as such lubricating agents as jelly and oils were unnecessary. (Comparative Example 2) Gloves for touch of anus were obtained by the similar method to that of Inventive Example 2 with the exception that no terminally aminated PEO (PEO amine # 6000, manufactured by Kawaken Finechemical) was used. The glove showed no lubricity on the surface in dry or wet conditions, and such lubricating agents as jelly and oils were necessary for using the glove. As is evident from the above table, all moldings of the inventive examples have smaller values of resistance than those of the comparative examples, showing generation of lubricity in the inventive products. Thus, it is apparent that there has been provided, in accordance with the present invention, a medical device in which lubricity is generated on at least a portion of its surface when the device is contacted with body fluids or exposed to physiological aqueous conditions. Since the inventive medical device is characterized in that said lubricity-generating portion is formed by thermoforming, lubricity can be added to the surface of the device markedly easily in comparison with the conventional method in which an oil is applied or a lubricity material is coated. In addition, its function is continually maintained, its peeling and the like do not occur and it meets the required eluting material test which means its excellent safety.

Claims: A process for producing a medical device in which lubricity is generated on at least a portion of its surface when it is brought into contact with a body fluid or under physiological aqueous conditions, said process comprising the step of: (a) thermoforming a lubricity-generating portion on the surface of said device, wherein (i) said lubricity-generating portion comprises a modified polyethylene oxide containing at least one reacting group selected from the group consisting of amino group, carboxyl group, and thiol group; and (ii) the surface of said device comprises a polymer modified with at least one member selected from the group consisting of maleic anhydride and glycidyl (meth)acrylate, and wherein said process is effected: (b) under conditions whereby said reacting group of the polyethylene oxide of the lubricity-generating portion reacts with said group of the polymer of the surface during thermoforming. The process according to claim 1, wherein said lubricity-generating portion further comprises a radiopaque agent. The process according to claim 2, wherein said agent is selected from the group consisting of tungsten, barium sulfate, bismuth oxycarbonate, and sodium iodide. The process according to anyone of claims 1 to 3, wherein the medical device comprises a catheter. The medical device being produced by any one of the process of claims 1 to 4.

Inventors: AOIKE TAKU, ISHII NAOKI, ISHIKAWA KENJI, KITOU HIDEAKI, SHIMURA KENICHI, ZUSHI YASUNOBU, AOIKE, TAKU, ISHII, NAOKI, ISHIKAWA, KENJI, KITOU, HIDEAKI, SHIMURA, KENICHI, ZUSHI, YASUNOBU, Aoike, Taku, c/o Terumo K.K., Ishii, Naoki, c/o Terumo K.K., Ishikawa, Kenji, c/o Terumo K.K., Kitou, Hideaki, c/o Terumo K.K., Shimura, Kenichi, c/o Terumo K.K., Zushi, Yasunobu, c/o Terumo K.K.
Applicants: TERUMO CORP, TERUMO KABUSHIKI KAISHA
Application year: 1996
Main classification: A61L27
IPC codes: A61L29, A61L31, A61L27