ANTIMALARIAL QUINOLIN DERIVATIVES

Abstract: N1-Aralkyl-N2-quinolin-4-yl-diamine derivatives of general formula (I), wherein R<1> signifies halogen or trifluoromethyl; R<2> signifies hydrogen, halogen or trifluoromethyl; A signifies (a) or (C5-C6)-cycloalkylene; n signifies 1-4; R<3> and R<4> each independently signify hydrogen or methyl; p signifies 0-3 and B signifies aryl, as well as pharmaceutically acceptable salts of basic compounds of general formula (I), for use as therapeutically active substances, especially as active substances against malaria.

Description: ANTIMALARIAL QUINOLIN DERIVATIVES The invention is concerned with quinoline deπvatives, especially Ni -aralkyl-N2-quinolin-4-yl-diamine derivatives of the general formula (CH 2 ) p \ , wherein signifies halogen or trifluoromethyl; R2 signifies hydrogen, halogen or trifluoromethyl; signifies or (C 5 -C 6 )-cycloalkylene; n signifies 1 -4; R 3 and R 4 each independently signify hydrogen or methyl; p signifies 0-3 and B signifies aryl, as well as pharmaceutically acceptable salts of basic compounds of general formula I. All possible stereoisomers as well as their racemates are included in formula I. A sub-group of compounds of formula I comprises those in which p is 1 -3 and the other substituents have the significances given above. These novel compounds have the property that they are active not only against chloroquine-sensitive, but also against chloroquine-resistant malaria pathogens. For this reason they are very well suited for the prophylaxis and treatment of malaria, especially in cases where the malaria pathogens are resistant to chloroquine. Objects of the present invention are the mentioned compounds of formula I as well as their pharmaceutically usable salts thereof per se and as therapeutically active substances, the manufacture of these compounds and salts and their use for therapeutic purposes, especially for the prevention or treatment of malaria, as well as medicaments containing a compound of formula I or a salt thereof and the production of such medicaments. The term "lower-alkyl" used in the present description denotes straight-chain or branched saturated hydrocarbon residues such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, s-butyl, t-butyl and the like. "Halogen" signifies chorine, bromine, fluorine or iodine. When A in formula I signifies an aliphatic hydrocarbon chain, branched chains, for example -CH(CH3)-CH2-, -CH2 CH(CH3)- or -CH2C(CH3)2-, are especially preferred. The term "cycloalkylene" embraces preferably cyclopentyl or cyclohexyl. The term "aryl" embraces conveniently phenyl or substituted phenyl, with the number of substituents preferably being 1 -3 and the substituents being selected from a group consisting of halogen, hydroxy, lower-alkyl, lower-alkoxy, CF3, cyano, di- lower-alkylamino or their N-oxides, phenyloxy, phenyl or methylsulphanyl. Furthermore, the term "aryl" conveniently embraces naphthyl, benzop ,3]dioxol or mono- or bicyclic aromatic hetero- cycles with 1 or 2 hetero atoms, especially N and/or 0, for example pyridyl, quinolyl or furyl. Rings such as phenyl, pyridin- 2-yl, pyridin-3-yl, pyridin-4-yl, naphthalen-1 -yl, naphthalen-2- yl, furan-2-yl, furan-3-yl or quinolin-4-yl are preferred. Preferred compounds of general formula I are especially those in which R 1 signifies chlorine, R 2 signifies hydrogen, p signifies 1 , A signifies -CH2-C(CH3)2- and B signifies a benzene ring which is unsubstituted, mono-substituted or di-substituted. Examples of such compounds are: N ι -(7-Chloro-quinolin-4-yl)-N2-(3-chloro-benzyl)-2- methyl-propane-1 ,2-diamine, N τ( 7-chloro-quinolin-4-y I )-N2-( benzyl )-2-methyl- propane-1 ,2-diamine, N ι -(7-chloro-quinolin-4-yl)-N2-(2-hydroxy-3-methoxy- benzyl)-2-methyl-propane-l ,2-diamine, N ι -(7-chloro-quinolin-4-yl)-N2-(2-hydroxy-5-methoxy- benzyl)-2-methyl-propane-l ,2-diamine and N ι -(7-chloro-quinolin-4-yl)-N2-(4-hydroxy-3-methoxy- benzyl)-2-methyl-propane-l ,2-diamine. Compounds of general formula I in which R 1 signifies chlorine, R 2 signifies hydrogen, p signifies 1 or 2, A signifies cyclohexane-l ,2-diyl or cyclohexane-1 ,4-diyl and B signifies a benzene ring which is unsubstituted, mono-substituted, di- substituted or tri-substituted are also preferred. Examples of such compounds are especially ( 1 S,2S)-N ι -(7-chloro-quinolin-4-yl)-N2-(benzyl)-cyclo- hexane-1 ,2-diamine, ( 1 S,2S)-N-| -(7-chloro-quinolin-4-yl)-N2-(4-chlorobeπzyl)- cyclohexane-1 ,2-diamine, ( 1 S,2S)-Nι -(7-chloro-quinolin-4-yl)-N2-(4-dimethylamino- benzyl)-cyclohexane-1 ,2-diamine, cis-N ι -(7-chloro-quinolin-4-yl)-N4-(4-dimethylamino- benzyl)-cyclohexane-1 ,4-diamine, cis-N ι -(7-chloro-qui noli n-4-y I )-N4-( benzyl )-cyclohexa ne- 1 ,4-diamine, cis-N τ(7-chloro-quinolin-4-yl)-N4-(3-chloro-benzyl)- cyclohexane-1 ,4-diamine, cis-Nι -(7-chloro-quinolin-4-yl)-N4-(2-hydroxy-4- methoxy-benzyl)-cyclohexane-l ,4-diamine, cis-Nι -(7-chloro-quinolin-4-yl)-N4-(3, 5-dimethoxy- benzyl)-cyclohexane-1 ,4-diamine, cis-N ι -( 7-chloro-quinolin-4-yl)-N4-(4-methylsulphanyl- benzyl)-cyclohexane- l ,4-diamine, cis-N ι -( 7-chloro-quinolin-4-yl)-N4-(4-diethylamino- benzyl)-cyclohexane-l ,4-diamine, cis-Nι -(7-chloro-quinolin-4-yl)-N4-(biphenyl-4-yl)methyl- cyclohexane-1 ,4-diamine, trans-Nι -(7-chloro-quinolin-4-yl)-N4-[2-(3 , 5-dimethoxy- phenyl)-ethyl]-cyclohexane-l ,4-diamine, cis-N ι -(7-chloro-quinolin-4-yl)-N4-(4-methoxy-benzyl)- cyclohexane-1 ,4-diamine, trans-Nι -(7-chloro-quinolin-4-yl)-N4-(4-dimethylamino- benzyl)-cyclohexane-l ,4-diamine and trans-Nι -(7-chloro-quinolin-4-yl)-N4-(2, 6-difluoro- benzyl)-cyclohexane-1 ,4-diamine. The novel compounds of formula I can be manufactured in accordance with the invention by a) reducing a Schiff's base of the general formula wherein the substituents have the significance described above, or b) reacting an amine of the formula with a compound of the formula X - (CH 2 ) p -B IV wherein X signifies a leaving group and the other substituents have the significance described above, or c) reacting a compound of the formula with an amine of the formula H 2 N- (CH 2 ) p -B VI wherein all substituents have the significance described above, or d) reacting a ketone or an aldehyde of the formula vπ and R 1 and R 2 have the significance set forth above, with an amine of formula VI and a reducing agent, and e) if desired, converting the compound obtained into a pharmaceutically acceptable acid addition salt. In accordance with process variant a) of the process in accordance with the invention a Schiff's base of formula II is reduced. Suitable reducing agents are complex hydrides, diborane, reactive metals or formic acid. The use of complex hydrides such as sodium borohydride is especially preferred. The reduction is carried out in a temperature range of 0 to 30°C, preferably at room temperature. Suitable solvents are alcohols or mixtures of alcohols with chlorinated hydrocarbons. Ethanol or an ethanol- dichloromethane mixture is preferred for the reduction with sodium borohydride. When formic acid is used as the reducing agent, formic acid or another dilute acid can also be used as the solvent. Compounds of formula I are obtained according to process variant b) by reacting amines of formula III with compounds of formula IV. Halogen or aliphatic or aromatic sulphonyloxy groups are suitable as the leaving group X in formula IV. Conveniently, the reaction is carried out in a solvent, for example in an alcohol such as methanol or ethanol or in an aprotic solvent such as acetonitrile, N,N-dimethylformarnide, N,N-dimethylacetamide or 1 -methyl-2-pyrrolidone, in a temperature range of 0 to 1 00°C within 1 to 24 hours. The precise reaction conditions depend on the corresponding reaction partners. The reaction of compounds of formula V with an amine of formula VI is effected in accordance with process variant c). Halogen or aliphatic or aromatic sulphonyloxy groups are also suitable here as the leaving group X. The reaction is conveniently effected in a temperature range between 1 20 and 1 80°C. Phenol, ethoxyethanol, dimethylacetamide or l -methyl-2-pyrrolidone is suitable as the solvent. The reaction duration can vary between 2 and 28 hours. The reaction of aldehydes or ketones of formula VII with an amine of formula VI according to process variant d) is effected in a manner known per se. Conveniently, VII and VI are reacted in a solvent such as alcohol or toluene, with a water-separating agent such as e.g. molecular sieve optionally being added, and then a reducing agent such as a complex hydride, e.g. sodium borohydride, diborane or a metal, is then added thereto. VII and VI can also be reacted in the presence of a reducing agent such as hydrogen and a catalyst or with formic acid. The conversion into a pharmaceutically usable salt is effected by adding an acid. Hydrochloric acid, methanesulphonic acid or acetic acid are especially preferred because of the physiological compatibility of the corresponding salts. Especially suitable solvents are conveniently: water, methanol, ethanol, isopropanol, diethyl ether, acetone, N,N-dimethyl- formamide or dioxan. The intermediates required for variants a)-d) of the process can be prepared according to methods known per se. Examples 1 1 8-1 24 describe some possibilities for the preparation of the required intermediates. The Schiff's bases of general formula II are conveniently obtained by reacting a diamine of formula III with an aldehyde of the formula o IL (CH 2 ) p . B vm The reaction is conveniently carried out in an inert gas atmosphere at a temperature which lies between 20°C and the boiling temperature of the solvent, for example of ethanol, toluene or dichloromethane. The reaction time can be between 1 and 24 hours, conveniently between 2 and 1 2 hours. The reaction water which is formed can be removed by water-binding agents such as a molecular sieve (preferably 4A), anhydrous sodium sulphate, by evaporation together with the solvent or by azeotropic distillation over a water separator. As mentioned earlier, the Nι -arylalkyl-N2-quinolin-4-yl- diamine derivatives of general formula I in accordance with the invention and their pharmaceutically usable salts have extremely valuable pharmacological properties. In particular, they have a very good activity against malaria pathogens. Their activity is equally good against chloroquine- resistant strains of the pathogen as against chloroquine- sensitive strains. Accordingly, the novel compounds can also be used for the prophylaxis and cure of malaria even in those cases where the pathogen does not respond to chloroquine. The activity of the novel compounds against not only chloroquine-resistant, but also chloroquine-sensitive malaria pathogens shows itself in a strong, in vitro measurable growth inhibition of various strains of the human-pathogenic Plasmodium falciparum, as set forth in Table 1 hereinafter. The ratio of the growth inhibition of a strain which is especially resistant to chloroquine and of a strain which is sensitive to chloroquine gives as the "resistance index" a measurement for the absence of a cross-resistance with chloroquine. Since, for all novel compounds the resistance index lies between 0.7 and 2.5, they inhibit the growth of sensitive as well as resistant strains of the malaria pathogen equally effectively. They are accordingly also suitable for the prophylaxis of a malaria disease and also for the treatment of a malaria disease even when chloroquine is ineffective. The good activity against malaria pathogens is also shown in animal experiments. The effective doses measured after oral and subcutaneous administration to mice infected with malaria pathogens are shown in Table 2 hereinafter. Test method for the determination of the activity aαainst Plasmodium falciparum in vitro The preparations are tested on intraerythrocytary stages of Plasmodium falciparum from asynchronous cultures according to the method of Desjardin et al. (Desjardins, R.E. et al: Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob. Agents Chemother. J_6, 710-71 8, ( 1 979)). The culture medium consists of RPMI 1 640 with the addition of 25 mM HEPES, 25 mM NaHCθ3, 100 μg/ml neomycin and 1 05 human serum (A + ). Human-A + erythrocytes are used as the Plasmodium falciparum host cells. The parasites are maintained at 37°C in an atmosphere of 3% O2, 4% CO2, 93% N and 95% relative humidity. In order to determine the activity, the preparations are dissolved in DMSO, pre-diluted in the culture medium to a suitable starting concentration and subsequently titrated-out on to microtitre plates in the 2nd stage over 6-7 steps. After the addition of the parasite culture (0.7% parasitemia in 2.5% erythrocyte suspension) the test plates are incubated under the conditions given above for 72 h. The parasite growth in the different preparation concentrations is determined using [G- 3 H]- hypoxanthin incorporation compared to untreated control cultures on the same test plates. The 50% growth inhibition (IC50) is calculated according to logit regression analysis from the resulting dosage-activity curve. The preparations are tested on at least one chloroquine- resistant and one chloroquine-sensitive Plasmodium falciparum strain. Additional sensitive and resistant strains are included for futher characterization. Test method for the determination of the activity against Plasmodium berαhei in vivo The preparations are tested on mice infected with malaria pathogens (Plasmodium berghei). Male albino mice (IBM:MORO(SPF), FUELLINSDORF) weighing about 25 g are used as the test animals. They are kept in climatized rooms at 21 -22°C in groups of 5 animals per cage. They receive ad libitum a diet feed with a low PABA content (NAFAG FUTTER " No. 9009 PAB-45, PABA content 45 mg/kg) and drinking water. On the first day of the test (DO) the test animals are infected with Plasmodium berghei (strain ANKA). For this there is used heparinized blood of a donor mouse with about 30% parasitemia, which is diluted with physiological saline such that it contains 1 0 8 parasitized erythrocytes per ml. 0.2 ml of this suspension is injected intravenously (i.v.) into the mice to be treated and into the control mice. In untreated control animals the parasitemia normally reaches 30-40% on the third day after the infection (D+3) and the test animals die between days +5 and +7. The substances to be tested are dissolved or suspended in distilled water or in a mixture of 7% Tween 80, 3% alcohol (96%) and water. Usually, 0.25 ml of this solution or suspension is administered once subcutaneously and perorally to groups of 5 test animals. Treatment is effected 24 hours after the infection. 1 0 control animals are treated in the same manner with solvent or suspension medium per test. All substances are tested in a first test in a single dosage of 10 mg/kg. Only those substances which in this test (1 0 mg/kg) have shown a parasitaemia reduction of 90% are used for the titration. Suitable dilutions of the test substance can be used to obtain an accurate titration of the activity. 48 hours after the treatment (D+3) blood smears are prepared from all animals using blood from tail veins and are stained with giemsa. The average erythrocyte infection rate (parasitemiea in %) in the control groups as well as in the groups which have been treated with the test compounds is determined by counting under a microscope. The difference in the average values of the infection rates of control group (100%) and treated groups is calculated and expressed as a percentage reduction (Gl%). The ED50 or ED90 is determined mathematically by means of the JMP programme (nonlinear fit). The ED50 (ED90) in mg/kg is that dose which after single administration reduces the average erythrocyte infection rate by 50% (90%) in comparison to the control group. 0 Table 1 : Values measured in vitro (IC50 vaqlues in ng/ml) for the growth inhibition of the human-pathogenenic Plasmodium falciparum strain NF54 as an example of a chloroquine-sensitive strain and of the human-pathogenenic Plasmodium falciparum K1 as an example of a chloroquine-resistant strain, as well as the "resistance index", the ratio of the IC50 value for the chloro¬ quine-resistant strain K1 and the IC50 value for the chloroquine- sensitive strain NF54, as a measurement of the resistance to the test substance. IC50 (ng/ml) 1C50 (ng/ml) Resistance for for index P. falciparum P. falciparum NF54 K1 2 mice: Gl% is the percentage reduction of the parasitemia after a single, peroral (po) or subcutaneous (sc) administered dose of 1 0 mg/kg of test substance; ED50 is the effective perorally administered dose of test substance. I L t r 5 " 6 The compounds of formula I and the pharmaceutically acceptable acid addition salts of the compounds of formula I can be used as medicaments, e.g. in the form of pharmaceutical preparations. The pharmaceutical preparations can be administered orally, e.g. in the form of tablets, coated tablets, dragees, hard and soft gelatine capsules, solutions, emulsions or suspensions. The administration can, however, also be effected rectally, e.g. in the form of suppositories, parenterally, e.g. in the form of injection solutions, or nasally. The compounds of formula I and the pharmaceutically acceptable acid addition salts of the compounds of formula I can be processed with pharmaceutically inert, inorganic or organic carriers for the production of pharmaceutical preparations. Lactose, corn starch or derivatives thereof, talc, stearic acid or its salts and the like can be used, for example, as such carriers for tablets, coated tablets, dragees and hard gelatine capsules. Suitable carriers for soft gelatine capsules are, for example, vegetable oils, waxes, fats, semi-solid and liquid polyols and the like. Depending on the nature of the active ingredient no carriers are, however, usually required in the case of soft gelatine capsules. Suitable carriers for the production of solutions and syrups are, for example, water, polyols, glycerol, vegetable oils and the like. Suitable carriers for suppositories are, for example, !7 natural or hardened oils, waxes, fats, semi-liquid or liquid polyols and the like. The pharmaceutical preparations can, moreover, contain preservatives, solubilizers, stabilizers, wetting agents, emulsifiers, sweeteners, colorants, flavorants, salts for varying the osmotic pressure, buffers, coating agents or antioxidants. They can also contain still other therapeutically valuable substances. Medicaments containing a compound of formula I or a pharmaceutically acceptable acid addition salt thereof and a therapeutically inert carrier are also an object of the present invention, as is a process for their manufacture which comprises bringing one or more compounds of formula I and/or pharma¬ ceutically acceptable acid addition salts thereof into a galenical administration form together with one or more therapeutically inert carriers. In accordance with the invention compounds of general formula I as well as their pharmaceutically acceptable acid addition salts can be used for the treatment or prevention of malaria and, respectively, for the production of corresponding medicaments. The dosage can vary within wide limits and will, of course, be fitted to the individual requirements in each particular case. In the case of oral administration the dosage lies in a range of about 1 0 mg to about 2.5 g per day of a compound of general formula I or the corresponding amount of a pharmaceutically acceptable acid addition salt thereof, although the upper limit can also be exceeded when this is found to be indicated. In the following Examples, which illustrate the present invention but are not intended to limit its scope in any manner, all temperatures are given in degrees Celsius. The 250 MHz- 1 H- NMR spectra were measured at room temperature; chemical shifts δ(ppm) relative to δ(TMS) = 0.0 ppm. < 3 Example 1 (2R)-N ι -(7-Chloro-quinolin-4-yl)-N2-(4-dimethy lam i no-benzyl )- propane-1 ,2-diamine trihydrochloride 0.35 g of (2R)-Nι -(7-chloro-quinolin-4-yl)-propane-l ,2- diamine (see Example 1 1 8) and 0.22 g of 4-dimethylamino- benzaldehyde are boiled under reflux in 50 ml of ethanol overnight. After evaporation of the solvent the residue is again taken up in 20 ml of ethanol, 0.05 g of sodium borohydride is added thereto and the mixture is left to react at room temperature overnight. The excess sodium borohydride is then decomposed by the addition of 5 ml of glacial acetic acid and the solvent is evaporated. After the addition of 10 ml of methanol the mixture is again evaporated. Addition of methanol and evaporation are repeated again, whereafter the mixture is purified by chromatography on 30 g of silica gel with a mixture of dichloromethane and methanol in the ratio by volume 10:1 . The product-containing fractions are combined and evaporated, and the residue is taken up in 5 ml of ethanol. After the addition of 5 ml of 3N isopropanolic hydrochloric acid the hydrochloride of the product precipitates and is recrystallized from ethanol/diethyl ether. Yield: 0.5 g (70%) of colourless crystalline (2R)-Nι -(7-chloro- quinolin-4-yl)-N2-(4-dimethylamino-benzyl)-propane- l ,2- diamine trihydrochloride; m.p. 220°C. ISP mass spectrum: peaks at 369 (M+H + , 8%), 236 (58%), 134 (100%); ^-NMR in DMS0-d 6 , d (ppm): 1.44 (d, J = 6.5 Hz, 3H), 2.92 (s, 6H), 3.58 (m, I H), 3.85 (m, 1 H), 4.0 - 4.5 (m, 3H), 6.95 (m, 2H), 7.07 (d, J = 7 Hz, 1 H), 7.50 (d, J = 8 Hz, 2H), 7.80 (dd, J = 2 and 9 Hz, I H), 8.14 (d, J = 2 Hz, 1 H), 8.63 (m, I H), 8.63 (m, I H), 8.86 (d, J = 9Hz, I H), 9.65 ( , 2H), 9.90 (m, 1 H), 14.65 (br.s, I H). °i Example 2 ( 2S)-N2-(7-Chloro-quinolin-4-yl)-N ι -(4-dimethylamino-beπzyl)- propane- 1 ,2-diamine trihydrochloride Analogously to Example 1 , from 4-dimethylamino-benz- aldehyde and (2S)-N2-(7-chloro-quinolin-4-yl)-propane-1 ,2- diamine (see Example 1 1 9) there is obtained (2S)-N2-(7-chloro- quinolin-4-yl)-N ι -(4-dimethylamino-benzyl)-propane-1 ,2- diamine trihydrochloride, m.p. 1 89°C (from EtOH/Et 2 0), in a yield of 57% of theory. ISP mass spectrum: peaks at 369 (M+H + , 20%), 236 (34%), 1 34 (1 00%); 1H-NMR in DMS0-d 6 , d (ppm): 1 .34 (d, J = 6.5 Hz, 3H), 2.89 (s, 6H), 3.1 9 (m, 1 H), 3.40 (m, I H), 4.05 (m, 2H), 4.64 (m, I H), 6.70 (d, J = 8 Hz, 2H), 7.04 (d, J = 7 Hz, 1 H), 7.37 (d, J = 8 Hz, 2H), 7.80 (dd, J = 2 and 9 Hz, 1 H), 8.09 (d, J = 2 Hz, 1 H), 8.61 (m, 1 H), 8.84 (d, J = 9Hz, 1 H) f 9.28 (d, J = 8 Hz, 1 H), 9.35 (m, 1 H), 9.55 (m, 1 H), 14.45 (br.s, I H). Example 3 N i -(7-Chloro-quinolin-4-yl)-N2-( 3,4-dichloro-benzyl)-2- methyl-propane-1 ,2-diamine 1 .25 g of N i -(7-chloro-quinolin-4-yl)-2-methyl-propane- 1 ,2-diamine and 0.88 g of 3,4-dichlorobenzaldehyde are heated under reflux in 1 0 ml of ethanol for 3 hours. In order to complete the reaction, the solvent is evaporated in a vacuum. The resulting Schif s base is again taken up in 20 ml of ethanol and reduced to the amine by the addition of 0.1 9 g of sodium borohydride. Excess reducing agent is decomposed after 2 hours by the addition of 1 0 ml of glacial acetic acid. The turbid solution is then evaporated on a rotary evaporator. 10 ml of methanol are added to the residue and the mixture is again evaporated. Addition of methanol and evaporation are repeated twice. The evaporation residue is then taken up in 25 ml of water. The pH is adjusted to 1 0 by the addition of dilute sodium hydroxide solution, with the product separating. It is purified by X recrystallization from 45 ml of ethyl acetate. Yield: 1 .09 g (53%), m.p. 1 78-179°C. 1H-NMR in DMSO-d6, δ (ppm): 1.1 7(s, 6H), 3.24 (d, J = 5 Hz, 2H), 3.69 (s, 2H), 6.59 (d, J = 6 Hz, 1 H), 6.70 (br. t, 1 H), 7.35 (dd, J = 2 5 Hz and 8 Hz, 1 H), 7.46 (dd, J = 2 Hz and 9 Hz, 1 H), 7.52 (d, J = 8 Hz, 1 H), 7.62 (d, J = 2 Hz, 1 H), 7.79 (d, J = 2 Hz, 1 H), 8.26 (d, J = 9 Hz, 1 H), 8.40 (d, J = 6 Hz, I H). The following products are obtained as free bases in an i o analogous manner using the corresponding aromatic aldehydes: Example 4 N i -(7-Chloro-quinolin-4-yl)-N2-(3-chloro-benzyl)-2-methyl- 1 5 propane- 1 ,2-diamine M.p.: 1 25-1 26°C (from AcOEt); ^-NMR in DMSO-d 6 , δ (ppm): 1 .1 8 (s, 6H), 3.24 (d, J = 5 Hz, 2H), 3.69 (s, 2H), 6.60 (d, J = 6 Hz, I H), 6.71 (m, I H), 7.45-7.74 (m, 3H), 7.43-7.49 (m, 2H), 7.80 (d, J = 2 Hz, 20 1 H), 8.27 (d, J = 9 Hz, 1 H), 8.41 (d, J = 6 Hz, 1 H). Example 5 N -| -(7-Chloro-quinolin-4-yl)-N2-(2,4-dichloro-benzyl)-2- 5 methyl-propane-1 ,2-diamine M.p.: 1 38-1 39°C (from MeCN); 1H-NMR in DMSO-d 6 , δ (ppm): 1.1 9 (s, 6H), 3.25 (d, J = 5 Hz, 2H), 3.73 (s, 2H) t 6.59 (d, J = 6 Hz, I H), 6.72 (m, 1 H), 7.39 (dd,J = 2 Hz and 8 Hz, 1 H), 7.46 (dd, J = 2 Hz and 9 0 Hz, 1 H), 7.64 (d, J = 8 Hz, 1 H), 7.79 (d, J = 2 Hz, 1 H), 8.24 (d, J = 9 Hz, 1 H), 8.41 (d, J = 6 Hz, I H). Example 6 N ] -(7-Chloro-quinolin-4-yl)-N2-(3-chloro-4-fluoro-benzyl)-2- methyl-propane-1 ,2-diamine M.p.: 164-1 65°C (from MeCN);1H-NMR in DMSO-d 6 , δ (ppm): 1 .17 (s, 6H), 3.24 (d, J = 5 Hz, 2H), 3.67 (s, 2H), 6.60 (d, J = 6 Hz, I H), 6.69 (m, 1 H), 7.25-7.38 (m, 2 H), 7.46 (dd, J = 2 Hz and 9 Hz, I H), 7.56 (dd, J = 2 Hz and 7 Hz, 1 H), 7.80 (d, J = 2 Hz, 1 H), 8.27 (d, J = 9 Hz, 1 H), 8.41 (d, J = 6 Hz, I H). Example 7 N i -(7-Chloro-quinolin-4-yl)-N2-(4-chloro-3-trifluoromethyl- benzyl)-2-methyl-propane- 1 ,2-diamine M.p.: 1 58-1 60°C (from MeCN);1H-NMR in DMSO-d 6 , δ (ppm): 1 .23 (s, 6H), 3.36 (s, 2H), 3.89 (s, 2H), 6.68 (d, J = 6 Hz, I H), 7.48 (dd, J = 2 Hz and 9 Hz, 1 H), 7.67 (d, J = 8 Hz, 1 H), 7.73 (m, 1 H), 7.82 (d, J = 2 Hz, 1 H), 7.92 (m, 1 H), 8.34 (d, J = 9 Hz, 1 H), 8.43 (d, J = 6 Hz, 1 H). Example 8 N i -(7-Chloro-quinolin-4-yl)-N2-(3-trifluoromethyl-benzyl)-2- methyl-propane-1 ,2-diamine M.p.: 1 56-1 57°C (from MeCN);1H-NMR in DMSO-d 6 , δ (ppm): 1 .19 (s, 6H), 3.25 (d, J = 5 Hz, 2H), 3.78 (s, 2H), 6.61 (d, J = 6 Hz, I H), 7.43 (dd, J = 2 Hz and 9 Hz, 1 H), 7.45-7.74 (m, 3H), 7.80 (d, J = 2 Hz, 1 H), 8.27 (d, J = 9 Hz, 1 H), 8.41 (d, J = 6 Hz, 1 H). Example 9 Ni -(7-Chloro-quinolin-4-yl)-N2-(4-trifluoromethyl-benzyl)-2- methyl-propane-1 ,2-diamine M.p.: 145-147 0 C (from MeCN);1H-NMR in DMS0-d 6 , δ (ppm): 1.19 (s, 6H), 3.25 (d, J = 5 Hz, 2H), 3.78 (s, 2H), 6.60 (d, J = 6 Hz, 1H), 6.73 (m, 1 H), 7.47 (dd, J = 2 Hz and 9 Hz, 1 H), 7.55-7.65 (m, 4H), 7.79 (d, J = 2 Hz, 1 H), 8.26 (d, J = 9 Hz, 1 H), 8.41 (d, J = 6 Hz, 1 H). Example 70: Ni -(7-Chloro-quinolin-4-yl)-N2-(3,5-bis-trifluoromethyl- benzyl)-2-methyl-propane-1 ,2-diamine M.p.: 140-141 °C (from AcOEt); 1 H-NMR in DMSO-d 6 , δ (ppm): 1.19 (s, 6H), 2.65 (t, J = 8 Hz, 1 H), 3.26 (d, J = 5 Hz, 2H), 3.89 (d, J = 8 Hz, 2H), 6.62 (d, J = 6 Hz, 1H), 6.73 (m, 1 H), 7.41 (dd, J = 2 Hz and 9 Hz, 1 H), 7.79 (d, J = 2 Hz, 1 H), 7.91 (s, 1 H), 8.06 (s, 2H), 8.26 (d, J = 9Hz, 1H), 8.39 (d, J = 6 Hz, 1H). Example 77: Ni -(7-Chloro-quinolin-4-yl)-N2-(pyridin-4-yl-methyl)-2- methyl-propane-1 ,2-diamine M.p.: 157-159°C (from MeCN);1H-NMR in DMSO-d 6 , δ (ppm): 1.17 (s, 6H), 3.25 (m, 2H), 3.73 (s, 2H), 6.61 (d, J = 6 Hz, IH), 6.74 (m, 1 H), 7.39 (d, J = 7 Hz, 2H), 7.48 (dd, J = 2 Hz and 9 Hz, 1 H), 7.79 (d, J = 2 Hz, 1 H), 8.28 (d, J = 9 Hz, 1 H), 8.40 (d, J = 6 Hz, 1 H), 8.45 (d, J = 7 Hz, 2H). Example 12 N l -(7-Chloro-quinolin-4-yl)-N2-(2,6-dichloro-benzyl)-2- methyl-propane-1 ,2-diamine M.p.: 1 54-1 55°C (from MeCN); 1H-NMR in DMSO-d 6 , δ (ppm): 1.25 (s, 6H), 2.0 (m, 1 H), 3.25 (d, J = 5 Hz, 2H), 3.87 (s, 2H), 6.59 (d, J = 6 Hz, I H), 6.61 (m, 1 H), 7.25-7.50 (m, 4H), 7.81 (d, J = 2 Hz, 1 H), 8.20 (d, J = 9 Hz, 1 H), 8.42 (d, J = 6 Hz, 1 H). Example 13 cis -N 1 -(7-Chloro-quinolin-4-yl)-N 4 -phenethyl-cyclohexane-1 ,4- diamine dihydrochloride Analogously to Example 3 using phenylacetaldehyde. Yield: 1 0%, dec. >250°C. El mass spectrum: peaks at 380 ((M+H)+, 1 00%), 276 (80%), 21 9 (50%) ; 1 H-NMR in DMS0-d6 , δ (ppm): 1 .96 (br,9H), 3.08 (br, 4H), 3.32 (br,1 H), 4.1 0 (br. l H), 8,93 (d, J = 7Hz, 1 H), 7.32 (m,5H), 7.80 (dd, J = 2 and 9Hz, 1 H), 8.1 2 (d, J = 2Hz, 1 H), 8.59 (d, J = 7Hz, 1 H), 8.72 (d, I H), 8.87 (d, J = 9Hz,1 H), 9,24 (br, 2H), 14.55 (br, I H). Example 14 cis-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -( 2,4,6-trimethoxy-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 3 using 2,4,6-tπmethoxybenzaldehyde. Yield: 37% of white crystals (from methanol/diethyl ether), m.p. El mass spectrum: peaks at 455 (M+, 4%), 1 96 (28%), 1 81 ( 100%); 1 H NMR in DMSO-d6 , δ (ppm): 1 .7-2.2 (m, 8H), 3.14 (br.1 H), 3.35 (s,2H), 3.82 (s, 3H). 3,83 (2xs,6H), 4.03 (br, 3H), 6.30 (s, 2H), 6.91 (d, J = 6Hz, 1 H), 7.76 (dd, J = 2 and 9Hz, 1 H), 8.1 7 (d, J = 2Hz, 1 H), 8.60 (br, 3H), 8.75 (d, J = 6Hz,1H), 8.94 (d, J = 9Hz,1H), 14.75(br,1H). Example 15 cis-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -(2,6-dichloro-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 3 using 2,6-dichlorobenzaldehyde. Yield 43% of white crystals (from methanol/ether). M.p. > 270°C. ISP mass spectrum: peaks at 434(M+, 100%), 436 ((M+2H)+, 90%); 1 H-NMR of the free base in CDCI 3 , δ (ppm): 1.60-2.00 (m, 9H), 2.73 (br, IH), 3.73 (br, IH), 4.09 (s, 2H), 5.05 (d, 1H), 6.43 (d, J = 5.5Hz, IH), 7.15 (m, IH), 7.30 (s, IH), 7.33 (s, IH), 7.35 (dd, J = 2 and 9Hz, 1H), 7.62 (d, J = 9Hz, IH), 7.95 (d, J = 2Hz, 1H), 8.51 (d, J = 5.5Hz, IH). Example 16 cis-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -(2,6-dimethoxy-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 3 using 2,6-dimethoxybenzaldehyde. Yield 58% of beige crystals (from methanol/ether). M.p.205°C ISP mass spectrum: peaks at 426 ((M+H)+, 100%); 1 H-NMR of beige crystals (from base in CDCI 3 , δ (ppm): 1.60-2.00 (m, 8H), 2.70 (br, 2H), 3.75 (br, 1H), 3.82 (s, 6H), 3.94 (s, 2H), 5,20 (d,1H), 6.41 (d, J = 7Hz, 1 H), 6.52 (d, J = 9Hz, 2H), 7.17 (t, J = 9Hz, 1 H), 7.35 (dd, J = 2 and 10Hz, 1H), 7.72 (d, J = 10Hz, 1H), 7.93 (d, J = 2Hz, IH), 8.51 (d, J = 7Hz, IH). Example 1 7 cis-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -( 2,3 ,6-trichloro-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 3 using 2,3,6-trichlorobenzaldehyde. Yield 44% of white crystals (from methanol/ether). M.p. > 270°C El mass spectrum: peaks at 469 (M+, 90%), 467(95%), 258(80%), 21 9(100%); 1 H-NMR of the free base in CDCI 3 , δ (ppm): 1.50-2.05 (m, 9H), 2.80 (br, I H), 3.70 (br, I H), 4.1 2 (s, 2H), 5.05 (d, I H), 6.43 (d, J = 5.5Hz, 1 H), 7.27 (d, J = 8.5Hz, 1 H), 7.34 (d, J = 8.5Hz, I H), 7.35 (dd, J = 2 and 9Hz, 1 H), 7.63 (d, J = 9Hz, I H), 7.95 (d, J = 2Hz, 1 H), 8.51 (d, J = 5.5Hz, 1 H). Example 18 cis-2-{ [4-(7-Chloro-quinolin-4-ylamino)-cyclohexylamino]- methyl}-3,5-dimethoxy-phenol dihydrochloride Analogously to Example 3 using 4,6-dimethoxysalicylaldehyde. Yield 23% of beige crystals (from methanol/ether). M.p. 244°C. ISP mass spectrum: peaks at 442 ((M+H)+, 100%); 1 H-NMR of the free base in CDCI3 δ (ppm): 1 .60-2.00 (m, 9H), 2.90 (br, 1 H), 3.75 (s, 3H), 3.76 (s, 3H), 4.03 (s, 2H), 5.00 (d, 1 H), 6.00 (d, J = 2Hz, 1 H), 6.06 (d, J = 2Hz, 1 H), 6.43 (d, J = 7Hz, 1 H), 7.40 (dd, J = 2 and 10Hz, 1 H), 7.70 (d, J = 10Hz, 1 H), 7.95 (d, J = 2Hz, 1 H), 8.50 (d, J = 7Hz, 1 H). Example 19 cis-N 1 -( 7-Chloro-quinolin-4-yl)-N 4 -(2, 6-difluoro-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 3 using 2,6-difluorobenzaldehyde. Yield 62% of white crystals (from methanol/ether). M.p. 225°C. ISP mass spectrum: peaks at 402 ((M+H)+, 1 00%), 276 (25%), 201 (75%); 1 H-NMR of the free base in CDCI 3 , δ (ppm): 1 .50-2.00 (m, 9H), 2.75 (m, 1 H), 3.70 (m, 1 H), 3.92 (s, 2H), 5.05 (d, I H), 6.42 (d, J = 5.5Hz, I H), 6.89 (m, 2H), 7.20 (m, I H), 7.35 (dd, J = 2 and 9Hz, 1 H), 7.62 (d, J = 9Hz, 1 H), 7.95 (d, J = 2Hz, 1 H), 8.50 (d, J = 5.5Hz, I H). Example 20 cis-Nι-(7-Chloro-quinolin-4-yl)-N 4 -(3-phenyl-propyl)-cyclohexane- 1 ,4-diamine dihydrochloride Analogously to Example 3 using 3-phenylpropionaldehyde. Yield 1 5% of white crystals (from methanol/ether). Dec. from 1 60°C. ISP mass spectrum: peaks at 445 ((M+H)+, 100%), 223 (7 2 (M+2H) 2+ ; 25%); 1 H-NMR of the dihydrochloride in d 6 -DMS0 δ (ppm): 1.64-2.25 (m, 1 0H), 2.69 (t,J = 7Hz, 2H),2.90 (br, 2H), 3.24 (br, 1 H), 4.08 (br, 1 H), 6.90 (d, J = 7Hz, I H), 7.26 (m,5H), 7.75 (dd, J = 2 and 9Hz, 1 H), 8.1 6 (d, J = 2Hz, 1 H), 8.58 (d, J = 7Hz, 1 H), 8.75 (d, br, 2H), 8.88 (d, J = 9Hz, 1 H), 9.1 8 (br,2H), 14.4 (br.l H). Example 21 cis-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -(4-methoxy-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 3 using anisaldehyde. Yield 34% of white crystals (from methanol/ether). M.p. >1 85°C El mass spectrum: peaks at 395 (M+, 26%), 260 (65%), 219 (34%), 1 21 ( 100%); 1 H-NMR of the dihydrochloride in d 6 -DMSO δ (ppm): 1 .66-2.25 (m, 8H), 3.1 8 (br, 1 H), 3.77 (s, 3H), 4.1 1 (br, 3H), 6.90 (d, J = 7Hz, 1 H), 6.98 (d, J = 8.6Hz, 2H), 7.55 (d, J = 8.6Hz, 2H), 7.78 (dd, J = 2 and 9Hz, 1 H), 8.1 1 (d, J = 2Hz, 1 H), 8.58 (d, J = 7Hz, 1 H), 8.64 (d, br, 2H), 8.87 (d, J = 9Hz, 1 H), 9.32 (br,2H), 14.5 (br,1 H). Example 22 cis-N 1 -(2-Chloro-6-nitro-benzyl)-N -(7-chloro-quinolin-4-yl)- cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 3 using 2-chloro-6-nitrobenzaldehyde. Yield 23% of white crystals (from methanol/ether). M.p. >260°C. ISP mass spectrum: peaks at 445 ((M+H)+, 1 00%), 223 (7 2 (M+2H) 2+ ; 25%); 1 H-NMR of the free base in CDCI 3) δ (ppm): 1 .50-2.00 (m, 9H), 2.85 (m, I H), 3.71 (m, I H), 4.06 (s, 2H), 5.03 (d, I H), 6.43 (d, J = 5.5Hz, 1 H),7.37 (m, 2H), 7.68 (m, 3H), 7.95 (d, J = 2Hz, I H), 8.51 (d, J = 5.5Hz, 1 H). Example 23 N i -(7-Chloro-quinolin-4-yl)-N2-(3 , 5-dichloro-benzyl)-2- methylpropane-1 ,2-diamine dihydrochloride 1 .25 g of Nι -(7-chloro-quinolin-4-yl)-2-methyl-propane- 1 ,2-diamine and 0.88 g of 3,5-dichlorobenzaldehyde are heated ander reflux in 10 ml of ethanol for 3 hours. The solvent is evaporated in a vacuum in order to complete the reaction. The resulting Schiff's base is again taken up in 1 0 ml of ethanol and reduced to the amine by the addition of 0.1 9 g of sodium borohydride. Excess reducing agent is decomposed after 3 hours by the addition of 10 ml of glacial acetic acid. The turbid solution is then evaporated on a rotary evaporator. The residue is taken up in 1 0 ml of methanol, which is again evaporated. Addition of methanol and evaporation are repeated twice. The evaporation residue is then dissolved in 1 5 ml of hot methanol. After the addition of 3.6 ml of 3N isopropanolic hydrochloric acid the hydrochloride of the product crystallizes upon cooling. The crude salt ( 1 .1 g) is purified by recrystallization from 30 ml of methanol. Yield: 0.63 g (26%), m.p. >250°C. 1H-NMR in DMS0-d 6 , δ (ppm): 1 .50 (s, 6H), 4.03 (br.s, 2H), 4.35 (m, 2H), 7.27 (d, J = 7 Hz, I H), 7.69 (m, 1 H), 7.82 (dd, J = 2 Hz and 9 Hz), 7.89 (m, 2H), 8.1 1 (d, J = 2 Hz, 1 H), 8.68 (d, J = 7 Hz, I H), 8.99 (d, J = 9 Hz, 1 H), 9.65 (br., 1 H), 9.8 (m, 2H), 14.5 (br.s, I H). The hydrochlorides of the following products are obtained in an analogous manner using the corresponding beπzaldehydes: Example 24 N i -(7-Chloro-quinolin-4-yl)-N2-(benzyl)-2-methyl-propane-1 ,2- diamine dihydrochloride M.p.: >250°C (from i-PrOH); El mass spectrum: fragments at 1 92 (1 6%), 1 48 (100%), 91 (96%); 1 H-NMR in DMS0-d 6 , δ (ppm): 1.53 (s, 6H), 4.06 (m, 2H), 4.29 (m, 2H), 7.28 (d, J = 7 Hz, 1 H), 7.40-7.45 (m, 3H), 7.70-7.82 (m, 3H), 8.1 7 (d, J = 2 Hz, 1 H), 8.67 (d, J = 7 Hz, I H), 9.03 (d, J = 9 Hz, I H), 9.70 (m, 3H), 14.65 (br.s, I H). Example 25 N i -(7-Chloro-quinolin-4-yl)-N2-(4-chloro-benzyl)-2-methyl- propane-1 ,2-diamine dihydrochloride M.p.: >250°C (from i-PrOH); El mass spectrum: fragments at 1 92 (43%), 1 82 (75%), 1 25 (100%); 1 H-NMR in DMS0-d 6 , δ (ppm): 1 .52 (s, 6H), 4.05 (m, 2H), 4.30 (m, 2H), 7.28 (d, J = 7 Hz, I H), 7.51 (d, J = 8.5 Hz, 2H), 7.75-7.80 (m, 3H), 7.70-7.82 (m, 3 H), 8.1 5 (d, J = 2 Hz, 1 H), 8.67 (d, J = 7 Hz, 1 H), 9.02 (d, J = 9 Hz, 1 H), 9.5-10.0 (m, 3H), 14.30 (br.s, I H). Example 26 N i -(7-Chloro-quinolin-4-yl)-N -(2,3-dichloro-benzyl)-2- methyl-propane-1 ,2-diamine dihydrochloride M.p.: >250°C (from i-PrOH); 1H-NMR in DMS0-d 6 , δ (ppm): 1.55 (s, 6H), 4.08 (m, 2H), 4.46 ( , 2H), 7.28 (d, J = 7.5 Hz, I H), 7.48 (t, J = 2^ 8 Hz, 1 H), 7.70-7.85 (m, 2H), 8.02 (dd, J = 2 Hz and 8 Hz, 1 H), 8.20 (d, J = 2 Hz, I H), 8.70 (d, J = 7.5 Hz, I H), 9.07 (d, J = 9 Hz, I H), 9.70 (m, I H), 1 0.00 (m, 2H), 14.90 (br.s, I H). Example 27 N i -( 7-Chloro-quinolin-4-yl)-N2-(4-chloro-3-fluoro-benzyl)-2- methyl-propane-1 ,2-diamine dihydrochloride M.p.: >250°C (from MeOH); 'H-NMR in DMSO-d 6 , δ (ppm): 1 .50 (s, 6H), 4.04 (m, 2H), 4.34 (m, 2H), 7.28 (d, J = 7 Hz, I H), 7.60 (dd, J = 2 Hz and 8 Hz, I H), 7.70 (t, J = 8 Hz, I H), 7.82 (dd, J = 2 Hz and 9 Hz, 1 H), 7.90 (dd, J = 2 Hz and 10 Hz), 8.10 (d, J = 2 Hz, 1 H), 8.68 (d, J = 7 Hz, 1 H), 8.98 (d, J = 9 Hz, 1 H), 9.6 (m, I H), 9.85 (m, 2H), 14.5 (br.s, 1 H). Example 28 N i -(7-Chloro-quinolin-4-y I )-N2-(2-hydroxy benzyl )-2-methyl- propane-1 ,2-diamine diacetate 1 .25 g of Ni -(7-chloro-quinolin-4-yl)-2-methyl-propane- 1 ,2-diamine and 0.54 g of salicylaldehyde are stirred ander reflux overnight in the presence of 1 .25 g of molecular sieve (E. Merck, 3A). Thereafter, the mixture is filtered and the solvent is evaporated. From a small amount of diethyl ether and ethyl acetate there is obtained a crystalline product which is again taken up in 20 ml of ethanol. After the addition of 0.1 9 g of sodium borohydride the mixture is left to react overnight, thereafter 5 ml of glacial acetic acid are added thereto and the mixture is evaporated to dryness. After the addition of 1 0 ml of methanol the mixture is again evaporated. Addition of methanol and evaporation are repeated twice. The residue is then crystallized from 1 0 ml of ethanol. 0.9 g (40%) of colourless crystalline product of m.p. 1 50°C is obtained. ISP-mass spectrum: peaks at 356 (M+H + , 65%), 250 (80%), 1 07 (100%); 1H-NMR in DMS0-d 6 , δ (ppm): 1 .20 (s, 6H), 1 .90 (s, 6H), 3.33 (s, 2H), 3.84 (s, 2H), 6.63-6.74 (m, 3H), 7.03-7.1 3 (m, 2H), 7.47 (dd, J = 2 and 9 Hz, 1 H), 7.80 (d, J = 2 Hz, 1 H), 8.31 (d, J =9Hz, 1 H), 8.41 ( d, J = 7 Hz, I H). Example 29 N i -( 7-Chloro-quinolin-4-yl)-N2-(2-hydroxy-4-methoxy-benzyl)- 2-methyl-propane-1 ,2-diamine dihydrochloride 1 .25 g of Ni -(7-chloro-quinolin-4-yl)-2-methyl-propane- 1 ,2-diamine and 0.76 g of 2-hydroxy-4-methoxy-benzaldehyde are stirred ander reflux overnight in 20 ml of ethanol in the presence of 1 .25 g of molecular sieve (E. Merck, 3A). The mixture is filtered, the solvent is evaporated and the residue is again taken up in 20 ml of ethanol. After the addition of 0.19 g of sodium borohydride the mixture is stirred at room temperature for 6 hours, thereafter 5 ml of glacial acetic acid are added thereto and the mixture is evaporated to dryness. 1 0 ml of methanol are added to the residue and the mixture is again evaporated. Addition of methanol and evaporation are repeated twice. Finally, the residue is taken up in 10 ml of hot ethanol, 10 ml of 3N isopropanolic hydrochloric acid are added thereto and the product is left to crystallize out as the dihydrochloride. Yield 1 .8 g (78%) of colourless crystalline powder, m.p. 220°C. ISP mass spectrum: peaks at 386 (M+H + , 20%), 250 (70%), 1 37 (100%); 1H-NMR in DMSO-d 6 , δ (ppm): 1 .48 (s, 6H), 3.71 (s, 3H), 4.02 (m, 2H), 4.10 (m, 2H), 6.44 (dd, J = 2 and 8 Hz, I H), 6.59 (d, J = 2 Hz, I H), 7.22 (d, J = 7 Hz, I H), 7.47 (d, J = 8 Hz, I H), 7.80 (dd, J = 2 Hz and 9 Hz, 1 H), 8.21 (d, J = 2Hz, 1 H), 8.67 (d, J = 7 Hz, 1 H), 9.02 (d, J = 9 Hz, 1 H), 9.30 (m, 2H), 9.57 (m,1 H), 10.40 (m, 1 H), 14.94 (br.s, I H). The hydrochlorides of the following products are obtained in an analogous manner using the corresponding aromatic aldehydes: Example 30 N i -(7-Chloro-quinolin-4-yl)-N2-(2-hydroxy-3-methoxy-benzyl)- 2-methyl-propane-1 ,2-diamine dihydrochloride Yield 82%, m.p.: 210-21 2°C (from EtOH/i-PrOH); ISP mass spectrum: peaks at 386 (M+H + , 44%), 250 (100%); ' H-NMR in DMSO- d 6 , δ (ppm): 1 .49 (s, 6H), 3.83 (s, 3H), 4.03 (m, 2H), 4.20 (m, 2H), 6.83 (t, J = 8 Hz, I H), 7.03 (dd, J = 1 .5 and 8 Hz, I H), 7.23 (m, 2H), 7.80 (dd, J = 2 Hz and 9 Hz, 1 H), 8.20 (d, J = 2 Hz, 1 H), 8.66 (d, J = 7Hz, I H), 9.01 (d, J = 9 Hz, 1 H), 9.36 (m, 3H), 9.59 (m, I H), 14.65 (br.s, 1 H). Example 31 N i -(7-Chloro-quinolin-4-yl)-N2-( 2-hydroxy-5-methoxy-benzyl)- 2-methyl-propane-1 ,2-diamine dihydrochloride Yield 44%, m.p.: >250°C (from EtOH/i-PrOH); ISP mass spectrum: peaks at 386 (M+H\ 67%), 250 (1 00%); 1 H-NMR in DMSO-d 6l δ (ppm): 1 .50 (s, 6H), 3.71 (s, 3H), 4.03 (m, 2H), 4.1 7 (m, 2H), 6.80-6.94 (m, 2H), 7.23-7.29 (m, 2H), 7.80 (dd, J = 2 Hz and 9 Hz, I H), 8.14 (d, J = 2 Hz, 1 H), 8.68 (d, J = 7Hz, 1 H), 8.97 (d, J = 9 Hz, I H), 9.34 (m, 2H), 9.50 (m, I H), 9.75 (m, I H), 14.65 (br.s, 1 H). Example 32 N i -(7-Chloro-quinolin-4-yl)-N2-( 3-hydroxy-benzyl)-2-methyl- propane-1 ,2-diamine dihydrochloride Yield 56%, m.p.: >250°C (from EtOH/i-PrOH); ISP mass spectrum: peaks at 356 (M+H + ); H-NMR in DMS0-d 6 , δ (ppm): 1 .50 (s, 6H), 4.04 (m, 2H), 4.1 8 (m, 2H), 6.83 (m, 1 H), 7.04-7.30 (m, 4H), 7.81 (dd, J = 2 Hz and 9 Hz, 1 H), 8.1 9 (d, J = 2 Hz, 1 H), 8.67 (d, J = 7Hz, 1 H), 9.02 (d, J = 9 Hz, 1 H), 9.65 (m, 3H), 9.74 (s, I H), 14.80 (br.s, I H). Example 33 N i -(7-Chloro-quinolin-4-yl)-N2-(4-hydroxy-3-methoxy-benzyl)- 2-methyl-propane-1 ,2-diamine dihydrochloride Yield 68%, m.p.: >250°C (from EtOH/i-PrOH); ISP mass spectrum: peaks at 386 (M+H\ 1 00%), 250 (52%); 1H-NMR in DMSO-d 6 , δ (ppm): 1 .50 (s, 6H), 3.81 (s, 3H), 4.04 (m, 2H), 4.1 7 (m, 2H), 6.80 (d, J = 8 Hz, 1 H), 7.04 (dd, J = 2 and 8 Hz, 1 H), 7.27 (d, J = 7 Hz, 1 H), 7.50 (d, J = 2, 1 H), 7.79 (dd, J = 2 Hz and 9 Hz, 1 H), 8.1 8 (d, J = 2 Hz, 1 H), 8.66 (d, J = 7Hz, 1 H), 9.04 (d, J = 9 Hz, 1 H), 9.60 (m, 3H), 14.83 (br.s, 1 H). Example 34 N i -(7-Chloro-quinolin-4-yl)-N2-(2-methoxy-benzyl)-2-methyl- propane-1 ,2-diamine dihydrochloride Yield 68%, m.p.: >250°C (from EtOH/i-PrOH); ISP mass spectrum: peaks at 370 (M+H + , 100%), 250 (75%); ' H-NMR in DMS0-d 6 , δ (ppm): 1 .50 (s, 6H), 3.82 (s, 3H), 4.05 (m, 2H), 4.20 (m, 2H), 7.00 (t, J = 8 Hz, 1 H), 7.09 (d, J = 8 Hz, I H), 7.26 (d, J = 7 Hz, 1 H), 7.43 (dt, J = 2 and 8 Hz, 1 H), 7.59 (dd, J = 2 and 8 Hz, 1 H), 7.80 (dd, J = 2 Hz and 9 Hz, 1 H), 8.20 (d, J = 2 Hz, 1 H), 8.68 (d, J = 7Hz, 1 H), 9.07 (d, J = 9 Hz, 1 H), 9.45 (m, 2H), 9.65 (m, 1 H), 14.83 (br.s, 1 H). Example 35 N i -(7-Chloro-quinolin-4-yl)-N2-(4-methoxy-benzyl)-2-methyl- propane- 1 , 2-diamine dihydrochloride M.p.: >250°C (from EtOH); ' H-NMR in DMS0-d 6 , δ (ppm): 1 .50 (s, 6H), 3.77 (s, 3H), 4.03 (m, 2H), 4.22 (m, 2H), 6.99 (d, J = 9 Hz, 2H), 7.27 (d, J = 7 Hz, 2H), 7.64 (d, J = 9 Hz, 2H), 7.81 (dd, J = 2 Hz and 9 Hz), 8.1 4 (d, J = 2 Hz, 1 H), 8.68 (d, J = 7 Hz, 1 H), 9.01 (d, J = 9 Hz, I H), 9.63 (m, 3 H), 1 4.65 (br.s, I H). Example 36 N i -(7-Chloro-quinolin-4-yl)-N2-(2,3-dimethoxy-benzyl)-2- methyl-propane- 1 ,2-diamine dihydrochloride M.p.: >250oC (from EtOH/i-PrOH); 'H-NMR in DMS0-d 6 , δ (ppm): 1.50 (s, 6H), 3.83 (s, 3H), 3.84 (s, 3H), 4.04 ( , 2H), 4.22 (m, 2H), 7.14 (d, J = 5 Hz, 2H), 7.25 (d, J = 7 Hz, I H), 7.35 (t, J = 5 Hz, I H), 7.81 (dd, J = 2 Hz and 9 Hz, 1 H), 8.14 (d, J = 2 Hz, 1 H), 8.69 (d, J = 7 Hz, 1 H), 9.00 (d, J = 9 Hz, 1 H), 9.54 (m, 3H), 14.65 (br.s, 1 H). Example 37 N l -(7-Chloro-quinolin-4-yl)-N2-(2,4-dimethoxy-benzyl)-2- methyl-propane-1 ,2-diamine dihydrochloride Yield 42%, m.p.: >250°C (from EtOH/i-PrOH); El mass spectrum: fragments at 301 , 208, 1 91 , 1 51 (100%); 1H-NMR in DMS0-d 6 , δ (ppm): 1 .49 (s, 6H), 3.79 (s, 3H), 3.80 (s, 3H), 4.02 (m, 2H), 4.1 1 (m, 2H), 6.54 -6.63 (m, 2H), 7.24 (d, J = 7 Hz, 1 H), 7.52 (d, J = 8 Hz, 1 H), 7.80 (dd, J = 2 Hz and 9 Hz, I H), 8.20 (d, J = 2 Hz, 1 H), 8.67 (d, J = 7Hz, 1 H), 9.08 (d, J = 9 Hz, 1 H), 9.35 (m, 2H), 9.63 (m, I H), 14.90 (br.s, 1 H). Example 38 N i -(7-Chloro-quinolin-4-yl)-N2-(2,5-dimethoxy-benzyl)-2- methyl-propane-1 ,2-diamine dihydrochloride Yield 72%, m.p.: >250°C (from EtOH/i-PrOH); ISP mass spectrum: peaks at 400 (M+H + , 1 00%), 384 (27%), 250 (85%); 'H-NMR in DMS0-d 6 , δ (ppm): 1.50 (s, 6H), 3.74 (s, 3H), 3.77 (s, 3H), 4.03 (m, 2H), 4.18 (m, 2H), 6.94-7.04 (m, 2H), 7.25 (d, J = 7 Hz, I H), 7.35 (d, J = 2 Hz, 1 H), 7.79 (dd, J = 2 Hz and 9 Hz, 1 H), 8.20 (d, J = 2 Hz, 1 H), 8.68 (d, J = 7Hz, 1 H), 9.06 (d, J = 9 Hz, 1 H), 9.60 (m, 3H), 1 4.80 (br.s, I H). 3^ Example 39 N i -(7-Chloro-quinolin-4-yl)-N2-( 3 ,4-dimethoxy-benzyl)-2- methyl-propane-1 ,2-diamine dihydrochloride Yield 72%, m.p.: >250°C (from EtOH/i-PrOH); H-NMR in DMS0-d 6 , δ (ppm): 1 .53 (s, 6H), 3.76 (s, 3H), 3.81 (s, 3H), 4.06 (m, 2H), 4.20 (m, 2H), 6.97 (d, J = 8.5 Hz, 1 H), 7.1 9 (dd, J = 2 Hz and 8.5 Hz, 1 H), 7.28 (d, J = 7.5 Hz, I H), 7.56 (d, J = 2 Hz, 1 H), 7.76 (dd, J = 2 and 8.5 Hz, 1 H), 8.23 (d, J = 2 Hz, 1 H), 8.65 (d, J = 7.5 Hz, 1 H), 9.09 (d, J = 8.5 Hz, 1 H), 9.75 (m, 3H), 1 5.00 (br.s, 1 H). Example 40 N i -(7-Chloro-quinolin-4-yl)-N2-(3 ,5-dimethoxy-benzyl)-2- methyl-propane-1 ,2-diamine dihydrochloride M.p.: >250°C (from EtOH); 1H-NMR in DMS0-d 6τ δ (ppm): 1 .51 (s, 6H), 3.78 (s, 6H), 4.05 (m, 2H), 4.22 (m, 2H), 6.51 (m, 1 H), 6.99 (m, 2H), 7.28 (d, J = 7 Hz, 1 H), 7.81 (dd, J = 2 Hz and 9 Hz), 8.14 (d, J = 2 Hz, I H) 8.68 (d, J = 7 Hz, I H), 9.01 (d, J = 9 Hz, I H), 9.67 (m, 3 H), 14.65 (br.s, I H). Example 41 N i -(7-Chloro-quinolin-4-yl)-N2-(3 ,4,5-trimethoxy-benzyl)-2- methyl-propane-1 ,2-diamine dihydrochloride Yield 60%, m.p.: >250°C (from EtOH/i-PrOH); ISP mass spectrum: peaks at 430 (M+H + ); 1H-NMR in DMS0-d 6 , δ (ppm): 1 .51 (s, 6H), 3.65 (s, 3H), 3.82 (s, 6H), 4.05 (m, 2H), 4.22 (m τ 2H), 7.18 (s, 2H), 7.28 (d, J = 7 Hz, 1 H), 7.80 (dd, J = 2 Hz and 9 Hz, 1 H), 8.10 (d, J = 2 Hz, 1 H), 8.66 (d, J = 7 Hz, 1 H), 8.97 (d, J = 9 Hz, 1 H), 9.64 (m, 3H), 14.55 (br.s, I H). 3 Example 42 N i -(7-Chloro-quinolin-4-yl)-N2-benzo[ 1 , 3 ]dioxol-5-yimethyl-2- methyl-propane-1 ,2-diamine dihydrochloride Yield 61 %, m.p.: >250°C (from EtOH/i-PrOH); ISP mass spectrum: peaks at 384 (M+H + ), 250 (79%); ] H-NMR in DMS0-d 6 , δ (ppm): 1 .49 (s, 6H), 4.04 (m, 2H), 4.23 (m, 2H), 6.98 (d, J = 7 Hz, I H), 7.1 7 (dd, J = 2 Hz and 7 Hz, 1 H), 7.30 (d, J = 7 Hz, 1 H), 7.39 (d, J = 2 Hz, 1 H), 7.80 (dd, J = 2 Hz and 9 Hz, I H), 8.14 (d, J = 2 Hz, I H), 8.67 (d, J = 7 Hz, I H), 9.00 (d, J = 9 Hz, I H), 9.63 (m, 3H), 1 4.58 (br.s 1 H). Example 43 N i -(7-Chloro-quinolin-4-yl)-N2-(4-phenoxy-benzyl)-2-methyl- propane-1 ,2-diamine dihydrochloride M.p.: >250oc (from MeOH); ] H-NMR in DMS0-d 6 , δ (ppm): 1 .51 (s, 6H), 4.05 (m, 2H), 4.28 (m, 2H), 7.00-7.08 ( m, 4 H), 7.1 5-7.21 (m, 1 H), 7.28 (d, J = 7.5 Hz, 2H), 7.39-7.46 (m, 2 H), 7.74 (d, J = 9 Hz, 2 H), 7.81 (dd, J = 2 Hz and 9 Hz), 8.14 (d, J = 2 Hz, I H), 8.69 (d, J = 7.5 Hz, 1 H), 9.01 (d, J = 9 Hz, I H), 9.66 (m, 3 H), 1 4.65 (br.s, 1 H). Example 44 N i -(7-Chloro-quinolin-4-yl)-N2-(4-methylsulphanyl-benzyl)-2- methyl-propane-1 , 2-diamine dihydrochloride M.p.: >250°C (from MeOH); 1H-NMR in DMS0-d 6> δ (ppm): 1 .50 (s, 6H), 2.50 (s, 3H), 4.03 (m, 2H), 4.25 (m, 2H), 7.28 (d, J = 7 Hz, 1 H), 7.32 (d, J = 9.5 Hz, 2 H), 7.65 (d, J = 9.5 Hz, 2H), 7.80 (dd, J = 2 Hz and 9 Hz, 1 H), 8.1 1 (d. J = 2 Hz, 1 H), 8.69 (d, J = 7 Hz, 1 H), 8.98 (d, J = 9 Hz, I H), 9.6 (m, 3H), 14.50 (br.s, I H). Example 45 N i -(7-Chloro-quinolin-4-yl)-N2-(4-dimethylamino-benzyl)-2- methyl-proρane-1 ,2-diamine dihydrochloride M.p.: >250°C (from MeOH); 1 H-NMR in DMSO-d 6 , δ (ppm): 1 .49 (s, 6H), 2.91 (s, 6H), 4.01 (m, 2H), 4.13 (m, 2H), 6.74 (d, J = 9 Hz, 2H), 7.25 (d, J = 7.5 Hz, 1 H), 7.48 (d, J = 9 Hz, 2H), 7.82 (dd, J = 2 Hz and 9 Hz, 1 H), 8.1 2 (d, J = 2 Hz, 1 H), 8.68 (d, J = 7.5 Hz, 1 H), 8.98 (d, J = 9 Hz, I H), 9.45 (m, 2H), 9.55 (m, I H), 14.60 (br.s, I H). Example 46 N ι -(7-Chloro-quinolin-4-yl)-N2-(4-diethylamino-benzyl)-2- methyl-propane-1 ,2-diamine trihydrochloride Yield 21 %, m.p.. > 250°C (from EtOH); ISP mass spectrum: peaks at 41 1 (M+H + , 5%) 250 (24%), 233 (1 6%), 206 ([M+2H + ] / 2, 100%), 1 62 (98%); H-NMR in DMS0-d 6 , δ (ppm): 1.05 (t, J = 7 Hz, 6H), 1 .51 (s, 6H), 3.44 (q, J = 7 Hz, 4H), 4.05 (m, 2H), 4.35 (m, 2H), 7.28 (d, J = 7.5 Hz, 1 H), 7.82 (dd, J = 2 Hz and 9 Hz, 1 H), 7.95, (m, 2H), 8.12 (d, J = 2 Hz, I H), 8.68 (d, J = 7.5 Hz, I H), 9.00 (d, J = 9 Hz, 1 H), 9.65 (m, 1 H), 9.85 (m, I H), 14.58 (br.s, 1 H). Example 47 N i -(7-Chloro-quinolin-4-yl)-N2-(4-nitro-benzyl)-2-methyl- propane-1 ,2-diamine dihydrochloride M.p.: >250°C (from EtOH/i-Pr ether; 1H-NMR in DMSO-d 6 , δ (ppm): 1 .54 (s, 6H), 4.08 (m, 2H), 4.48 (m, 2H), 7.30 (d, J = 7 Hz, 2H), 7.81 (dd, J = 2 Hz and 9 Hz), 8.04 (d, J = 8.5 Hz, 2 H), 8.1 3 (d, J = 2 Hz, 1 H), 8.30 (d, J = 8.5 Hz, 2H), 8.68 (d, J = 7 Hz, I H), 9.00 (d, J = 9 Hz, 1 H), 9.66 (m, 1 H), 10.0 (m, 2H), 1 4.65 (br.s, I H). Example 48 N i -(7-Chloro-quinolin-4-yl)-N2-(3-cyano-benzyl)-2-methyl- propane-1 ,2-diamine dihydrochloride M.p.: >250°C (from MeOH); 1H-NMR in DMSO-d 6 , δ (ppm): 1 .51 (s, 6H), 4.04 (m, 2H), 4.38 (m, 2H), 7.28 (d, J = 7 Hz, 1 H), 7.67 (t, J = 8 Hz, 1 H), 7.80 (dd, J = 2 Hz and 9 Hz, 1 H), 7.92 (d, J = 8 Hz, 1 H), 8.05- 8.1 2 (m, 2H), 8.25 (s, 1 H), 8.69 (d, J = 7 Hz, 1 H), 8.97 (d, J = 9 Hz, 1 H), 9.6 (m, 1 H), 9.8 (m, 2H), 14.50 (br.s, 1 H). Example 49 N l -(7-Chloro-quinolin-4-yl)-N2-(4-cyano-benzyl)-2-methyl- propane-1 ,2-diamine dihydrochloride M.p.: >250°C (from EtOH/i-Pr ether; ' H-NMR in DMS0-d 6 , δ (ppm): 1 .52 (s, 6H), 4.07 (m, 2H), 4.42 (m, 2H), 7.29 (d, J = 7 Hz, 2H), 7.81 (dd, J = 2 Hz and 9 Hz), 7.92-8.00 (m, 4 H), 8.14 (d, J = 2 Hz, 1 H), 8.69 (d, J = 7 Hz, 1 H), 9.01 (d, J = 9 Hz, 1 H), 9.66 (m, 3 H), 14.65 (br.s, I H). Example 50 N i -(7-Chloro-quinolin-4-yl)-N2-(4-isopropyl-benzyl)-2-methyl- propane-1 ,2-diamine dihydrochloride M.p.: 210°C (dec.) (from i-PrOH); 1H-NMR in DMS0-d 6 , δ (ppm): 1.20 (d, J = 8,5 Hz, 6H), 1 .50 (s, 6H), 2.92 (sept, J = 7 Hz, 1 H), 4.03 (m, 2H), 4.24 (m, 2H), 7.28 (d, J = 7 Hz, I H), 7.32 (d, J = 8 Hz, 2H), 7.62 (d, J = 8 Hz, 2H), 7.80 (dd, J = 2 Hz and 9 Hz, 1 H), 8.1 3 (d, J = 2 Hz, 1 H), 8.68 (d, J = 7 Hz, 1 H), 8.98 (d, J = 9 Hz, 1 H), 9.60 (m, 3H), 14.60 (br.s, I H). 3S Example 51 N i -(7-Chloro-quinolin-4-yl)-N -(bipenyl-4-yl-methyl)-2- methyl-propane-1 ,2-diamine dihydrochloride M.p.: >250°C (from MeOH); 1H-NMR in DMSO-d 6 , δ (ppm): 1 .54 (s, 6H), 4.06 (m, 2H), 4.34 ( , 2H), 7.28 (d, J = 7 Hz, I H), 7.35-7.55 (m, 3H), 7.65-7.85 (m, 7H), 8.12 (d, J = 2 Hz, 1 H), 8.69 (d, J = 7 Hz, 1 H), 8.99 (d, J = 9 Hz, 1 H), 9.60 (m, 1 H), 9.70 (m, 2H), 14.60 (br.s, 1 H). Example 52 N i -(7-Chloro-quinolin-4-yl)-N2-(naphthalen-l -yl-methyl)-2- methyl-propane-1 ,2-diamine dihydrochloride M.p.: 180 O C (dec.) (from MeOH); ] H-NMR in DMS0-d 6 , δ (ppm): 1 .46 (s, 6H), 3.60 (s, 2H), 4.43 (s, 2H), 6.77 (d, J = 6 Hz, I H), 7.4-7.6 (m, 4H), 7.75-7.95 (m, 4H), 8.23 (d, J = 8 Hz, I H), 8.42-8.47 (m, 2H). Example 53 N i -(7-Chloro-quinolin-4-yl)-N2-(naphthalen-2-yl-methyl)-2- methyl-propane-1 ,2-diamine dihydrochloride M.p.: >250°C (from MeOH/water); 1H-NMR in DMS0-d 6 , δ (ppm): 1 .55 (s, 6H), 4.08 (m, 2H), 4.47 (m, 2H), 7.27 (d, J = 7 Hz, 1 H), 7.55- 7.60 (m, 2H), 7.80-8.05 (m, 5H), 8.1 2 (d, J = 2 Hz, 1 H), 8.22 (m, 1 H), 8.69 (d, J = 7 Hz, 1 H), 9.00 (d, J = 9 Hz, 1 H), 9.70 (m, 1 H), 9.75 (m, 2H), 14.60 (br.s, I H). 3 Example 54 N ι -(7-Chloro-quinolin-4-yl)-N2-(furan-2-yl-methyl)-2-methyl- propane-1 ,2-diamine dihydrochloride Yield 36%, m.p.: >250°C (from EtOH/i-PrOH); 1 H-NMR in DMSO-d 6 , δ (ppm): 1 .47 (s, 6H), 4.02 (m, 2H), 4.38 (m, 2H), 6.55 (m, 1 H), 6.79 (m, I H), 7.14 (d, J = 7.5 Hz, 1 H), 7.75-7.85 (m, 2H), 8.21 (d, J = 2 Hz, 1 H), 8.64 (d, J = 7.5 Hz, 1 H), 9.07 (d, J = 9 Hz, 1 H), 9.65 (m, 1 H), 9.90 (m, 2H), 14.90 (br.s, I H). Example 55 N i -(7-Chloro-quinolin-4-yi)-N2-(furan-3-yl-methyl)-2-methyl- propane-1 ,2-diamine dihydrochloride Yield 74.5%, m.p.: >250°C (from EtOH/i-PrOH); ' H-NMR in DMS0-d 6 , δ (ppm): 1 .48 (s, 6H), 4.02 (m, 2H), 4.19 (m, 2H), 6.95 (m, 1 H), 7.27 (d, J = 8.5 Hz, I H), 7.74 (m, 1 H), 7.90 (dd, J = 2.5 and 9 Hz, I H), 7.95 (m, 1 H), 8.1 5 (d, J = 2.5 Hz, 1 H), 8.67 (d, J = 8.5 Hz, 1 H), 9.03 (d, J = 9 Hz, I H), 9.65 (m, 3 H), 14.6 (br.s, I H). Example 56 N i -(7-Chloro-quinolin-4-yl)-N2-(pyridin-2-yl-methyl)-2- methyl-propane-1 ,2-diamine trihydrochloride M.p.: >250°C (from EtOH); ' H-NMR in DMS0-d 6 , δ (ppm): 1 .51 (s, 6H), 4.08 (d, J = 6 Hz, 2H), 4.55 (m, 2H), 7.28 (d, J = 7.5 Hz, I H), 7.50- 7.60 (m, I H), 7.75-7.87 (m, 2H), 8.0-8.1 (m, I H), 8.20 (d, J = 2 Hz, I H), 8.60-8.75 (m, 2H), 9.00 (d, J = 9 Hz, I H), 9.70 (m, I H), 9.90 (m, 2H), 14.90 (br.s, I H). Example 57 N i -(7-Chloro-quinolin-4-yl)-N2-(pyridin-3-yl-methyl)-2- methyl-propane-1 ,2-diamine trihydrochloride M.p.: 180°C (dec.) (from EtOH); ' H-NMR in DMSO-d 6 , δ (ppm): 1 .54 (s, 6H), 4.07 (s, 2H), 4.38 (s, 2H), 7.30 (d, J = 7.5 Hz, 1 H), 7.49 (dd, J = 6 Hz and 8.5 Hz, 1 H), 7.78 (dd, J = 2 Hz and 9 Hz, 1 H), 8.1 6 (d, J = 2 Hz, 1 H), 8.23-8.28 (m, 1 H), 8.60 (dd, J = 2 Hz and 6 Hz, 1 H), 8.67 (d, J = 7.5 Hz, 1 H), 8.90 (d, J = 2 Hz, 1 H), 9.08 (d, J = 9 Hz, 1 H), 9.70 (m, I H), 10.0 (m, 2H), 14.8 (br., I H). Example 58 N i -(7-Chloro-quinolin-4-yl)-N2-(quinolin-4-yl-methyl)-2- methyl-propane-1 ,2-diamine trihydrochloride M.p.: 207-209°C (from MeOH); 1H-NMR in DMS0-d 6 , δ (ppm): 1 .66 (s, 6H), 4.25 (d, J = 6.5 Hz, 2H), 5.09 (m, 2H), 7.36 (d, J = 7 Hz, 1 H), 7.76 (dd, J = 2 Hz and 9 Hz, 1 H), 7.93 (m,1 H), 8.10 (m, 1 H), 8.23 (d, J = 2 Hz, 1 H), 8.44 (m, 2H), 8.66 (m, 2 H), 9.1 0 (d, J = 9 Hz, 1 H), 9.34 (d, J = 7 Hz, 1 H), 9.85 (m, 1 H), 10.66 (m, 2H), 1 5.00 (br.s, 1 H). Example 59 N i -( 7-Chloro-quinolin-4-yl)-N2-(2,4-bis-trifluoromethyl- benzyl)-2-methyl-propane-1 ,2-diamine dihydrochloride M.p.: 260°C (dec.) (from MeOH); 'H-NMR in DMSO-d 6 , δ (ppm): 1.54 (s, 6H), 4.12 (s, 2H), 4.50 (s, 2H), 7.30 (d, J = 7.5 Hz, 1 H), 7.78 (dd, J = 2 Hz and 9 Hz, 1 H), 8.1 1 (s, 1 H), 8.20 (d, J = 2 Hz, 1 H), 8.23- 8.28 (m, 1 H), 8.60-8.70 (m, 2 H), 9.08 (d, J = 9 Hz, 1 H), 9.75 (m, 1 H), 1 0.35 (m, 2H), 14.80 (br.s, I H). 4- Example 60 ( 1 S,2S)-N ι -(7-Chloro-quinolin-4-yl)-N2-(benzyl)-cyclohexane- 1 ,2-diamine hydrochloride ( 1 :2) 0.3 g of N-(7-chloro-quinolin-4-yl)-cyclohexane-l ,2- diamine and 0.1 3 ml of benzaldehyde are stirred at 20°C in 3 ml of ethanol for 3 hrs. The solvent is evaporated in order to complete the reaction. The resulting Schiff's base is again dissolved in 3 ml of ethanol, cooled in ice ander argon and then treated portionwise with 0.3 g of sodium borohydride and stirred without cooling for a further 20 hrs. Excess reducing agent is decomposed by the addition of 3 ml of acetone. Thereafter, the mixture is diluted with 30 ml of 0.3N NaOH and extracted twice with 30 ml of dichloromethane each time. The crude product obtained from these extracts is purified by flash chromatography on silica gel with ethyl acetate and ethyl acetate/methanol 5:1 . The purified product is converted into the hydrochloride with ethanolic hydrochloric acid and precipitated by dilution with 2-butanone. Yield: 260 mg (54%), m.p. >200°C (dec). ISP mass spectrum: peaks inter alia at 366 (M+H + ); ' H-NMR in DMSO-d 6 , δ (ppm): 1 .25-2.40 (m, 8H), 3.75 (m, I H), 4.30 (m, 3H), 7.1 8 (d, J = 7, 2H), 7.37 (m, 3H), 7.54 (m τ 2H), 7.78 (dd, J = 2 Hz and 9 Hz, 1 H), 8.1 0 (d, 1 H, J = 2Hz, 1 H), 8.62 (d, J = 7 Hz, 1 H), 8.88 (d, J = 9 Hz, 1 H), 9.40 (m,l H). The following compounds are obtained in an analogous manner using the correspondingly substituted benzaldehydes: Example 61 ( 1 S,2S)-N ι -(7-Chloro-quinolin-4-yl)-N2-(4-chloro-benzyl)- cyclohexane-1 ,2-diamine dihydrochloride M.p. 21 0°C (from EtOH/2-butanone); El mass spectrum: fragments at 399 (M + ), 274; Η-NMR in DMS0-d 6 , δ (ppm): 1 .25-2.40 ( , 8H), 3.75 ( , 1 H), 4.30 (m, 3H), 7.1 2 (d, J = 7, 2H), 7.43 (d, J = 8.4, 2H), 7.59 (d, J = 8.4, 2H), 7.76 (dd, J = 2 Hz and 9Hz, 1 H), 8.09 (d, J = 2Hz, 1 H), 8.59 (d, J = 7 Hz, I H,), 8.87 (d, J = 9 Hz, I H), 9.32 (m, I H). Example 62 5 ( 1 S,2S)-N ι -(7-Chloro-quinolin-4-yl)-N2-(2,4-dichloro-benzyl)- cyclohexane-1 ,2-diamine dihydrochloride M.p. 204-220°C (from EtOH/2-butanone); ISP mass spectrum: o peaks at 434 (M+H + ); 1H-NMR in DMSO-d 6 , δ (ppm): 1 .25-2.40 (m, 8H), 3.83 (m, I H), 4.27 (s, 2H), 4.40 (m,1 H), 7.1 2 (d, J = 7 Hz, 2H), 7.43 (dd, J = 2.1 Hz and 8.3 Hz, 1 H), 7.60 (d, J = 2.1 Hz, 1 H), 7.75 (dd, J = 2 Hz and 9 Hz, 1 H), 7.80 (d, J =8.3 Hz, 1 H), 8.14 (d, J = 2 Hz, I H), 8.60 (d, J = 7 Hz, I H), 8.93 (d, J = 9 Hz, I H), 9.50 5 (m, 1 H). Example 63 ( 1 S,2S)-N ι -(7-Chloro-quinolin-4-yl)-N2-(3 ,4-dichloro-benzyl)- 0 cyclohexane-1 ,2-diamine dihydrochloride M.p.: dec. from 21 0°C (from EtOH/2-butanone); El mass spectrum: fragments at 433 (M + , 8%), 274 (1 00%), 1 79 (45%), 1 59 (38%); ISP mass spectrum: peaks at 434 (M+H + ); 1 H-NMR in DMS0-d 6 , δ (ppm): 5 1 .25-2.40 (m, 8H), 3.75 (m, 2H), 4.30 (m, 2H), 7.1 4 (d, J = 7Hz, 2H), 7.58 (m, 1 H), 7.64 (m, 1 H), 7.78 (dd, J = 2 Hz and 9 Hz, I H), 7.93 (d, J = 2Hz, 1 H), 8.1 2 (d, J = 2 Hz, 1 H), 8.60 (d, J = 7 Hz, 1 H), 8.92 (d, J = 9Hz, I H), 9.30 (m, 2H), 9.50 (d, J = 8 Hz, I H), 10.25 (m, 1 H), 14.55 (br.s, I H). 0 Example 64 ( l S,2S)-N ι -(7-Chloro-quinolin-4-yl)-N2-(2,4-bis-trifluoro- methyl-benzyl)-cyclohexane-1 ,2-diamine dihydrochloride 5 M.p. from 185°C (from EtOH/2-butanone); dec; ISP mass spectrum: peaks at 502 (M+H + ); 1H-NMR in DMSO-d 6 , δ (ppm): 1 .25-2.40 (m, 8H), 3.2-3.7 (m, 2H), 4.27 (m, 3H), 4.40 (m, 1 H), 7.1 2 (d, J = 7Hz, 2H), 7.73 (dd, J = 2 Hz and 9 Hz, IH), 7.93 (m, 2H), 8.10 (m, 2H), 8.57 (d, J = 7 Hz, IH), 8.82 (d, J = 9, IH), 9.36 (m, IH). Example 65 (1 S,2S)-Nι -(7-Chloro-quinolin-4-yl)-N2-(3,4,5-trimethoxy- benzyl)-cyclohexane-1 ,2-diamine dihydrochloride M.p. >250°C (from EtOH/2-butanone); ISP mass spectrum: peaks at 456 (M+H + ); 1H-NMR in DMS0-d 6 , δ (ppm): 1.25-2.40 (m, 8H), 3.60 (s, 3H), 3.70 (s, 6H), 3.75-4.50 (m, 4H), 6.97 (s, 2H), 7.14 (d, J = 7Hz, 2H), 7.74 (dd, J = 2 Hz and 9 Hz, 1 H), 8.14 (d, J = 2 Hz, 1 H), 8.61 (d, J = 7 Hz, 1 H), 8.94 (d, J = 9 Hz, 1 H), 9.48 (m, 1 H) Example 66 (1 S,2S)-Nι -(7-Chloro-quinolin-4-yl)-N2-(4-dimethylamino- benzyl)-cyclohexane-l ,2-diamine dihydrochloride M.p. 220-223°C (from EtOH/Et 2 0); ISP mass spectrum: peaks at 409 (M+H + , 50%), 276 (70%), 134 (100%); ' H-NMR in DMS0-d 6 , δ (ppm): 1.25-2.40 (m, 8H), 2.90 (s, 6H), 3.60 (m, 2H), 4.18 (m, 2H), 4.32 (m, IH), 6.85 (m, 2H), 7.14 (d, J = 7Hz τ 2H), 7,38 (d, J = 8 Hz, 2H), 7.78 (dd, J = 2 Hz and 9 Hz, 1 H) 8.12 (d, J = 2 Hz, 1 H), 8.61 (m, 1 H), 8.91 (d, J = 9Hz, 1 H), 9.05 (m, 1 H), 9.45 (d, J = 8 Hz, 1 H), 9.75 (m, IH), 14.55 (br.s, IH). Example 67 ( 1 S,2S)-Nι -(7-Chloro-quinolin-4-yl)-N2-(4-cyano-benzyl)- cyclohexane-1 ,2-diamine dihydrochloride M.p. 226-230°C (from EtOH/Et 2 0); ISP mass spectrum: peaks at 391 (M+H\ 100%), 276 (33%); 1H-NMR in DMS0-d 6 , δ (ppm): 1.25- 2.40 (m, 8H), 3.71 (m, 1 H), 4.25-4.40 (m, 3H), 7.16 (d, J = 7Hz, 2H), 7.77-7.81 (m, 3H), 7.88 (d, J = 8 Hz, 2H), 8.08 (d, J = 2 Hz, 1 H), 8.62 (d, J = 7 Hz, 1 H), 8.86 (d, J = 9Hz, 1 H), 9.41 (d, J = 8 Hz, IH), 9.50 (m, IH), 10.5 (m IH), 14.40 (br.s, IH). Example 68 cis-N i -( 7-Chloro-quinolin-4-yl)-N3 -(4-chloro-benzyl )- 5 cyclopentane-1 ,3-diamine dihydrochloride 0.24 g of cis-N-(7-chloro-quinolin-4-yl)-cyclopentyl-1 ,3- diamine and 0.21 g of 4-chloro-benzaldehyde are boiled ander reflux in 50 ml of ethanol overnight. After evaporation of the 1 0 solvent the residuejis again taken up in 50 ml of ethanol, 0.1 g of sodium borohyride is added thereto and the mixture is left to react at room temperature for 6 hrs. The excess sodium borohydride is then decomposed by the dropwise addition of 5 ml of glacial acetic acid and the solvent is evaporated. After the ι 5 addition of 1 0 ml of methanol the mixture is again evaporated. Addition of methanol and evaporation are repeated once more. The residue is thereafter purified by chromatography on 30 g of silica gel with a mixture of dichloromethane and methanol (in the ratio by volume 1 0: 1 ). The product-containing fractions are 20 combined and evaporated, and the residue is taken up in 5 ml of ethanol. After the addition of 5 ml of 3N isopropanolic hydrochloric acid the hydrochloride of the product separates and is recrystallized from ethanol/diethyl ether. 5 Yield: 0.55 g (78%) of colourless crystalline cis-Ni -(7-chloro- quiπolin-4-yl)-N3-(4-chloro-benzyl)-cyclopentane- 1 ,4-diamine dihydrochloride; m.p 1 91 -1 93°C (from EtOH/Et 2 0). El mass spectrum with peaks at 385 (M + , 38%), 246 (92%), 205 (98%), 1 78 (44%), 1 25 (1 00%); ' H-NMR in DMS0-d 6 , δ (ppm): 30 2.00-2.30 (m, 5H), 2.55-2.65 (m, I H), 3.34 (m, 2H), 3.58 (m, I H), 4.20 (s, 2H), 4.36 (m, I H), 6.91 (d, J = 7Hz, I H), 7.53 (d, J = 8 Hz, 2H), 7.66 (d, J = 8 Hz, 2H), 7.75 (dd, J = 2 and 9 Hz, I H), 8.06 (d, J = 2 Hz, 1 H), 8.60 (d, J = 7 Hz, 1 H), 9.06 (d, J = 9Hz, 1 H), 9.50 (m, I H), 9.90 (m, I H), 1 4.30 (br.s, I H). 5 - Example 69 cis-N i -(7-Chloro-quinolin-4-y I )-N4-(4-dimethy lam i no-benzyl )- cyclohexane-1 ,4-diamine trihydrochloride 5 1 g of cis-N-(7-chloro-quinolin-4-yl)-cyclohexyl- 1 ,4- diamine and 0.54 g of 4-dimethylamino-benzaldehyde are boiled on a water separator in 50 ml of toluene overnight. After evaporation of the toluene the residue is taken up in 20 ml of i o ethanol and 5 ml of dichloromethane, 0.13 g of sodium borohydride is added thereto and the mixture is left to react at room temperature for 6 hours. The excess sodium borohydride is decomposed with 2.5 ml of glacial acetic acid and the solvent is evaporated. After the addition of 1 0 ml of methanol the mixture 1 5 is again evaporated. Addition of methanol and evaporation are repeated once. The residue is thereafter purified by chroma¬ tography on 50 g of silica gel with a mixture of dichloromethane, methanol and water (in the ratio by volume 8:3:0.6). The product- containing fractions are combined and evaporated, and the residue 20 is taken up in 5 ml of ethanol. After the addition of 5 ml of 3N isopropanolic hydrochloric acid the hydrochloride of the product separates and is recrystallized from ethanol/diethyl ether. Yield: 1 .5 g (80%) of colourless crystalline trihydrochloride; m.p. 25 228°C. ISP mass spectrum: peaks at 409 (M+H + , 1 00%), 276 (75%), 1 34 (76%); 1H-NMR in DMSO-d 6 , δ (ppm): 1.70-2.20 (m, 8H), 2.97 (s, 3H), 3.1 7 (m, I H), 4.09 (m, 3H), 6.92 (d, J = 7Hz, I H), 7.05 (m, 2H), 7.57 (m, 2H), 7.78 (dd, J = 2 and 9 Hz, I H), 8.14 (d, J = 2 Hz, I H), 8.59 (d, J = 7 Hz, I H), 8.71 (m, I H), 8.90 (d, J = 9Hz, I H), 9.35 (m, 30 2H), 14.65 (br.s, 1 H). The following compounds are obtained in an analogous manner using the correspondingly substituted benzaldehydes: - Example 70 cis-Ni -(7-Chloro-quinolin-4-yl)-N4-(benzyl)-cyclohexane- 1 ,4- diamine dihydrochloride Yield 68%; m.p. >250oC (from EtOH/Et 2 0); ISP mass spectrum: peaks at 366 (M+H\ 100%), 276 (85%); 1H-NMR in DMS0-d 6 , δ (ppm): 1.68-1.84 (m, 2H), 1.90-2.30 (m, 6H), 3.20 (m, I H), 4.08 (m, I H), 4.1 8 (m, 2H), 6.93 (d, J = 7Hz, I H), 7.40-7.50 (m, 3H), 7.60- 7.70 (m, 2H), 7.80 (dd, J = 2 Hz and 9 Hz, 1 H) τ 8.12 (d, J = 2 Hz, 1 H), 8.59 (d, J = 7 Hz, 1 H), 8.69 (m, 1 H), 8.89 (d, J = 9Hz, 1 H), 9.44 ( m, 2H), 9.32 (m, 1 H), 14.53 (s, I H). Example 71 cis-N i -( 7-Chloro-quinolin-4-yl)-N4-(3-chloro-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Yield 70%; m.p. 1 98-200°C (from Et0H/Et 2 0); ISP mass spectrum: peaks at 400 (M+H + , 1 00%), 276 (62%); ' H-NMR in DMS0-d 6 , δ (ppm): 1.70-2.24 (m, 8H), 3.25 (m, I H), 4.08 (m, 1 H), 4.21 (m, 2H), 6.92 (d, J = 7Hz, I H), 7.45-7.53 (m, 2H), 7.61 -7.67 (m, I H), 7.78 (dd, J = 2 and 9 Hz, 1 H), 7.80 (m, 1 H), 8.13 (d, J = 2 Hz, 1 H), 8.59 (d, J = 7 Hz, 1 H), 8.70 (m, I H), 8.89 (d, J = 9Hz, 1 H), 9.56 (m, 2H), 1 4.60 (br.s, 1 H). Example 72 cis-N i -(7-Chloro-quinolin-4-yl)-N4-(4-chloro-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Yield 39%; m.p. 1 90-1 95°C (from EtOH/Et 2 0); ISP mass spectrum: peaks at 400 (M+H + , 100%), 276 (90%), 1 25 (100%); 1 H-NMR in DMS0-d 6 , δ (ppm): 1 .70-2.23 (m, 8H), 3.1 6 (m, 1 H), 4.08 (m, 1 H), 4.18 (m, 2H), 6.90 (d, J = 7Hz, 1 H), 7.51 (d, J = 8 Hz, 2H), 7.71 (d, J = 8 Hz, 2H), 7.77 (dd, J = 2 Hz and 9 Hz, 1 H), 8.1 8 (d, J = 2 Hz, I H), 8.58 (d, J = 7 Hz, I H), 8.73 ( , 1 H), 8.92 (d, J = 9Hz, I H), 9.65 (m, 2H), 14.83 (s, 1 H). Example 73 cis-Ni -(7-Chloro-quinolin-4-yl)-N4-(2,4-dichloro-benzyl)- cyclohexane-l,4-diamine dihydrochloride Yield 55%; m.p.204-205°C (from Et0H/Et 2 0); ISP mass spectrum: peaks at 434 (M+H + , 100%), 159 (25%); 1H-NMR in DMS0-d 6 , δ (ppm): 1.74-2.25 (m, 8H), 3.34 (m, IH), 4.10 (m, 1H), 4.30 (m, 2H), 6.95 (d, J = 7Hz, 1 H), 7.57 (dd, J = 2 and 8 Hz, 1 H), 7.76 (d, J = 2Hz, 1 H), 7.79 (dd, J = 2 and 9 Hz, 1 H), 7.92 (d, J = 8 Hz, 1 H), 8.12 (d, J = 2 Hz, 1 H), 8.59 (d, J = 7 Hz, 1 H), 8.70 (m, 1 H), 8.88 (d, J = 9Hz, IH), 9.55 (m, 2H), 14.53 (br.s, IH). Example 74 cis-Ni -(7-Chloro-quinolin-4-yl)-N4-(3,4-dichloro-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Yield 35%; m.p.212°C (from EtOH/Et 2 0); ISP mass spectrum: peaks at 434 (M+H + , 100%), 276 (68%), 159 (86%); ' H-NMR in DMSO-d 6 , δ (ppm): 1.72-2.25 (m, 8H), 3.24 (m, IH), 4.07 (m, IH), 4.21 (m, 2H), 6.92 (d, J = 7Hz, 1H), 7.67 (dd, J = 1.5 and 8 Hz, IH), 7.73 (d, J = Hz, 1 H), 7.79 (dd, J = 2 and 9 Hz, 1 H), 8.02 (d, J = 1.5 Hz, 1 H), 8.12 (d, J = 2 Hz, 1H), 8.59 (d, J = 7 Hz, IH), 8.72 (m, IH), 8.89 (d, J = 9Hz, 1H), 9.60 (m, 2H), 14.57 (br.s, IH). Example 75 cis-Ni -(7-Chloro-quinolin-4-yl)-N4-(3,5-dichloro-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Yield 16%; m.p.204-205°C (from EtOH/Et 2 0); ISP mass spectrum: peaks at 434 (M+H + , 100%); ' H-NMR in DMS0-d 6 , δ (ppm): 1.72-2.23 (m, 8H), 3.26 (m, 1H), 4.08 (m, 1H), 4.22 (m, 2H), 6.93 (d, J = 7Hz, 1H), 7.69 (m, IH), 7.77-7.83 (m, 3H), 8.10 (d, J = 2 Hz, IH), 8.60 (d, J = 7 Hz, IH), 8.70 (m, IH), 8.88 (d, J = 9Hz, IH), 9.55 (m, 2H), 14.47 (br.s, IH). Example 76 cis-Ni -(7-Chloro-quinolin-4-yl)-N4-(4-chloro-3-fluoro-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Yield 70%; m.p. 158°C (from EtOH/i-PrOH); ISP mass spectrum: peaks at 418 (M+H + , 100%), 276 (88%), 143 (61%); 1H-NMR in DMS0-d 6 , δ (ppm): 1.70-1.85 (m, 2H), 1.90-2.20 (m, 6H), 3.11 (m, 1 H), 4.06 (m, 1 H), 4.22 (m, 2H), 6.92 (d, J = 7Hz, 1 H), 7.53 (m, 1 H), 7.69 (t, J = 8 Hz, 1 H), 7.76-7.86 (m, 2H), 8.11 (d, J = 2 Hz, 1 H), 8.59 (d, J = 7 Hz, 1H), 8.68 (m, 1H), 8.87 (d, J = 9Hz, 1H), 9.60 (m, 2H), 14.50 (br.s, 1H). Example 77 cis-Ni -(7-Chloro-quinolin-4-yl)-N4-(3,5-bis-trifluoromethyl- benzyl)-cyclohexane-1 ,4-diamine dihydrochloride Yield 41%; m.p.215°C (from EtOH/Et 2 0); ISP mass spectrum: peaks at 502 (M+H\ 67%), 276 (100%); 1H-NMR in DMS0-d 6 , δ (ppm): 1.75-2.25 (m, 8H), 3.36 (m, 1H), 4.09 (m, IH), 4.43 (m, 2H), 6.94 (d, J = 7Hz, 1 H), 7.80 (dd, J = 2 and 9 Hz, 1 H), 8.13 (d, J = 2 Hz, 1 H), 8.19 (m, 1 H), 8.48 (m, 2H), 8.60 (d, J = 7 Hz, 1 H), 8.76 (m, 1 H), 8.89 (d, J = 9Hz, IH), 9.70 (m, 2H), 14.60 (br.s, IH). Example 78 cis-Ni -(7-Chloro-quinolin-4-yl)-N4-(2-hydroxy-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Yield 92%; m.p.200-202°C (from EtOH/Et 2 0); ISP mass spectrum: peaks at 382 (M+H + , 100%); 1H-NMR in DMS0-d 6 , δ (ppm): 1.72-2.24 (m, 8H), 3.21 (m, IH), 4.11 (m, 3H), 6.85 (t, J = 8 Hz, IH), 6.95 (d, J = 7Hz, 1 H), 7.00 (d, J = 8 Hz, 1 H), 7.24 (dt, J = 2 and 8 Hz, 1 H), 7.49 (dd, J = 2 and 8 Hz, 1 H), 7.80 (dd, J = 2 and 9 Hz, 1 H), 8.13 (d, J = 2 Hz, IH), 8.59 (d, J = 7 Hz, 1H), 8.69 (m, IH), 8.88 (d, J = 9Hz, IH), 9.00 (m, 2H), 10.27 (s, IH), 14.55 (br.s, IH). 4-S Example 79 cis-Ni -(7-Chloro-quinolin-4-yl)-N4-(2-hydroxy-4-methoxy- benzyl)-cyclohexane-1 ,4-diamine dihydrochloride Yield 75%; m.p.200°C (from EtOH/Et 2 0); ISP mass spectrum: peaks at 412 (M+H + , 100%); 1H-NMR in DMS0-d 6 , δ (ppm): 1.70-2.22 (m, 8H), 3.14 ( , IH), 3.71 (s, 3H), 4.04 (m, 3H), 6.46 (dd, J = 2 and 8 Hz, 1 H), 6.54 (d, J = 2 Hz, 1 H), 6.94 (d, J = 7 Hz, 1 H), 7.37 (d, J = 8 Hz, 1 H), 7.80 (dd, J = 2 Hz and 9 Hz, 1 H), 8.13 (d, J = 2 Hz, 1 H), 8.60 (d, J = 7 Hz, 1 H), 8.70 (m, 1 H), 8.86 (d, J = 9 Hz, 1 H), 8.88 (m, IH), 10.30 (s, IH), 14.53 (br.s, IH). Example 80 cis-Ni -(7-Chloro-quinolin-4-yl)-N4-(2-hydroxy-5-methoxy- benzyl)-cyclohexane-1 ,4-diamine dihydrochloride Yield 86%; m.p. 180-185°C (from EtOH/Et 2 0); ISP mass spectrum: peaks at 412 (M+H + , 4%), 269 ( 49%), 187 (83%), 165 (100%); 1H-NMR in DMS0-d 6 , δ (ppm): 1.70-2.25 (m, 8H), 3.21 (m, 1H), 3.70 (s, 3H), 4.09 (m, 3H), 6.80-6.92 (m, 3H), 7.16 (d, J = 2 Hz, IH), 7.80 (dd, J = 2 Hz and 9 Hz, 1 H), 8.09 (d, J = 2 Hz, 1 H), 8.59 (d, J = 7 Hz, 1H), 8.61 (s, IH), 8.85 (d, J = 9Hz, 1H), 9.02 (m, 2H), 9.75 (m, IH), 14.45 (br.s, 1H). Example 81 cis-Ni -(7-Chloro-quinolin-4-yl)-N4-(2,4-dimethoxy-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Yield 87%; m.p. >250°C (from EtOH/Et 2 0); ISP mass spectrum: peaks at 426 (M+H + , 100%), 276 (54%), 187 (55%), 165 (60%), 151 (49%); 1H-NMR in DMS0-d 6 , δ (ppm): 1.70-2.20 (m, 8H), 3.08 (m, 1H), 3.79 (s, 3H), 3.83 (s, 3H), 4.05 (m, 3H), 6.59 (dd, J = 2 and 8 Hz, IH), 6.64 (d, J = 2 Hz, 1H), 6.92 (d, J = 7Hz, IH), 7.44 (d, J = 8 Hz, 2H), 7.80 (dd, J = 2 Hz and 9 Hz, 1 H), 8.12 (d, J = 2 Hz, IH), 8.59 (d, J = 7 Hz, 1H), 8.73 (m, IH), 8.88 (d, J = 9Hz, IH), 8.92 (m, 2H), 14.52 (s, 1H). Example 82 cis-Ni -(7-Chloro-quinolin-4-yl)-N4-(3,5-dimethoxy-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Yield 67%; m.p. 197-198°C (from EtOH/i-PrOH); ISP mass spectrum: peaks at 426 (M+H + , 100%), 276 (90%), 151 (93%); 1 H-NMR in DMS0-d 6 , δ (ppm): 1.70-2.23 ( , 8H), 3.20 (m, 1H), 4.11 (m, 3H), 6.53 (t, J = 2 Hz, 1 H), 6.69 (d, J = 2 Hz, 2H), 6.93 (d, J = 7 Hz, 1 H), 7.80 (dd, J = 2 and 9 Hz, 1 H), 8.11 (d, J = 2 Hz, 1 H), 8.59 (d, J = 7 Hz, 1H), 8.71 (m, 1H), 8.89 (d, J = 9Hz, 1H), 9.44 (m, 2H), 14.50 (br.s, 1H). Example 83 cis-Ni -(7-Chloro-quinolin-4-yl)-N4-(4-methylsulphanyl- benzyl)-cyclohexane-1 ,4-diamine dihydrochloride Yield 83%; m.p.181-182°C dec. (from EtOH/Et 2 0); ISP mass spectrum: peaks at 412 (M+H + , 100%), 276 ( 26%); 1H-NMR in DMS0-d 6 , δ (ppm): 1.68-1.85 (m, 2H), 1.90-2.25 (m, 6H), 3.19 (m, 1 H), 3.34 (s, 3H), 4.08 (m, 1 H), 4.14 (m, 2H), 6.92 (d, J = 7Hz, 1 H), 7.31 (d, J = 8 Hz, 2H), 7.57 (d, H = 8 Hz, 2H), 7.79 (dd, J = 2 Hz and 9 Hz, 1H), 8.10 (d, J = 2 Hz, IH), 8.59 (d, J = 7 Hz, IH), 8.64 (m, IH), 8.87 (d, J = 9Hz, IH), 9.38 (m, 2H), 14.50 (br.s, IH). Example 84 cis-Ni -(7-Chloro-quinolin-4-yl)-N4-(4-nitro-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Yield 52%; m.p. >260°C (from EtOH/Et 2 0); ISP mass spectrum: peaks at 411 (M+H\ 100%), 276 (25%); 1H-NMR in DMSO-d 6 , δ (ppm): 1.70-2.24 (m, 8H), 3.25 (m, 1H), 4.09 (m, IH), 4.34 (m, 2H), 6.92 (d, J = 7Hz, IH), 7.80 (dd, J = 2 Hz and 9 Hz, 1H), 7.94 (d, Si J = 8 Hz, 2H), 8.10 (d, J = 2 Hz, I H), 8.31 (d, J = 8 Hz, 2H), 8.59 (d, J = 7 Hz, 1 H), 8.70 (m, 1 H), 8.88 (d, J = 9Hz, 1 H), 9.64 (m, 2H), 1 4.45 (br.s, 1 H). Example 85 cis-N i -(7-Chloro-quinolin-4-y I) -N4-(4-diethy lam i no-benzyl )- cyclohexane-1 ,4-diamine trihydrochloride Yield 52%; m.p. >260°C (from EtOH/Et 2 0); ISP mass spectrum: peaks at 41 1 (M+H + , 100%), 276 (25%); 1H-NMR in DMS0-d 6 , δ (ppm): 1 .70-2.24 (m, 8H), 3.25 (m, 1 H), 4.09 (m, I H), 4.34 (m, 2H), 6.92 (d, J = 7Hz, 1 H), 7.80 (dd, J = 2 Hz and 9 Hz, 1 H), 7.94 (d, J = 8 Hz, 2H), 8.10 (d, J = 2 Hz, I H), 8.31 (d, J = 8 Hz, 2H), 8.59 (d, J = 7 Hz, 1 H), 8.70 (m, 1 H), 8.88 (d, J = 9Hz, 1 H), 9.64 (m, 2H), 14.45 (br.s, I H). Example 86 cis-N i -(7-Chloro-quinolin-4-yl)-N4-(4-cyano-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Yield 60%; m.p. >250°C (from EtOH/i-PrOH); ISP mass spectrum: peaks at 391 (M+H + , 100%); 1H-NMR in DMS0-d 6 , δ (ppm): 1 .71 -1 .87 (m, 2H), 1 .92-2.25 (m, 8H), 3.22 (m, 1 H), 4.08 (m, 1 H), 4.29 (m, 2H), 6.93 (d, J = 7Hz, I H), 7.79 (dd, J = 2 Hz and 9 Hz, I H), 7.89 (d, J = 8 Hz, 2H), 7.94 (d, J = 8 Hz, 2H), 8.1 3 (d, J = 2 Hz, 1 H), 8.59 (d, J = 7 Hz, I H), 8.70 (m, I H), 8.89 (d, J = 9Hz, I H), 9.71 (m, 2H), 14.56 (br.s, 1 H). Example 87 cis-N i -(7-Chloro-quinolin-4-yl)-N4-(biphenyl-4-yl-methyl)- cyclohexane-1 ,4-diamine dihydrochloride Yield 86%; m.p. 21 0-21 2°C (from EtOH/Et 2 0); ISP mass spectrum: peaks at 442 (M+H + , 100%), 1 67 (55%); 'H-NMR in DMS0-d 6 , δ (ppm): 1 .70-1 .86 (m, 2H), 1 .93-2.30 (m, 6H), 3.25 (m, 1 H), 4.08 (m, I H), 4.23 (m, 2H), 6.93 (d, J = 7Hz, I H), 7.40 (m, I H), 7.49 (m, 2H), 7.60-7.83 (m, 7H), 8.1 3 (d, J = 2 Hz, 1 H), 8.60 (d, J = 7 Hz, 1 H), 8.71 (m, 1 H), 8.91 (d, J = 9Hz, I H), 9.50 (m, 2H), 14.56 (br.s, I H). Example 88 trans-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -[2-(3,4-dimethoxy-phenyl)- ethyl]-cyclohexane-1 ,4-diamine dihydrochloride 275 mg 4-(7-chloroquinolin-4-ylamino)-cyclohexanone (see Example 1 24) and 181 mg of homoveratrylamine are boiled at reflux for 3 hours in 5 ml of ethanol in the presence of molecular sieve. The solution, which is cooled and freed from the molecular sieve, is concentrated to dryness. The residue is again taken up in 5 ml of ethanol and treated under argon at +5°C with 37 mg of sodium borohydride. After 1 hour the mixture is concentrated and the residue is suspended in dichloromethane. The excess reducing agent is decomposed by the addition of 2 ml of 3N sodium hydroxide solution. The mixture is diluted with water and the dichloromethane is separated. The dried organic phase is concentrated. The residue is chromatographed on silica gel with dichloromethane/methanol (3:1 ). The free base obtained is crystallized as the dihydrochloride by treatment with 3N hydrochloric acid in methanol. Yield: 280 mg (54%) of white crystals, m.p. 210°C. ISP mass spectrum: peaks at 440.5 ((M+H)+, 23%), 276.4 (75%), 221 (1 OO "1 H NMR of the free base in CDCI 3 d (ppm): 1 .32 (br, 5H), 2.06 (br,2H), 2.23 (br,2H), 2.55 (br,1 H), 2.77 (m,2H), 2.91 (m, 2H), 3.87 (s, 1 H), 3,88 (s.1 H), 4.80 (d, 1 H), 6.42 (d, J = 6Hz, 1 H), 6.78 (m, 3H), 7.35 (dd, J = 2 and 9Hz, 1 H), 7.61 (d, J = 9Hz, 1 H), 7.94 (d, J = 2Hz, I H), 8.52 (d, J = 6Hz). 5^ Example 89 trans-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -phenethyl-cyclohexane-1 ,4- diamine dihydrochloride 5 Analogously to Example 88 using phenethylamine. Yield: 23% of white crystals (from ethanol/ether). Dec. from 21 0°C ISP mass spectrum: peaks at 380 ((M+H)+, 35%), 276 (100%); 1 H o NMR in DMS0-d6, δ (ppm): 1.65 (m, 4H), 2.05 (br, 2H), 2.25 (br, 2H), 3.09 (br, 5H), 3.90 (br, 1 H), 7.05 (d, J = 7Hz, 1 H), 7.31 (m, 5H), 7.75 (dd, J = 2 and 7.5Hz, 1 H), 8.1 3 (d, J = 2Hz, 1 H), 8.53 (d, J = 7Hz, 1 H), 8.84 (d, J = 7.5Hz, 1 H), 9.1 5 (d, J = 9Hz, 1 H), 9.46 (br, 2H), 14.6 (br, I H). 5 Example 90 trans-Nι -(7-Chloro-quinolin-4-yl)-N 4 -(3, 5-dimethoxy-phenyl)- cyclohexane-1 ,4-diamine hydrochloride 0 Analogously to Example 88 using 3,5-dimethoxyaniline and 72 hours reflux for imine formation. Yield: 8%, Dec. 204°C. El mass spectrum: peaks at 41 1 (M + , 1 00%), 258 (35%), 1 92 (30%); 1 H NMR of the free base in CDCI 3 δ (ppm): 1 .66 (br, 4H), 2.05 (br, 4H),3.40 (br, I H), 3.70 (br, I H), 3.75 (s, 6H), 3.85 (br, 1 H), 6.52 5 (br, 3H), 7.04 (d, J = 7.5 Hz, 1 H), 7.76 (dd, J = 2 and 9Hz, 1 H), 8.10 (d, J = 2Hz, I H), 8.51 (br,1 H), 8.81 (d, J = 9Hz, I H), 9.09 (d, J = 7.5Hz, I H), 14.4 (br, I H). Example 91 0 trans-Nι -(7-Chloro-quinolin-4-yl)-N 4 -[2-(2,4-dichloro-phenyl)- ethyl]-cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using 2,4-dichlorophenethylamine. Yield: 35% of white crystals (from methanol/ether), dec. 230°C. 5 ISP mass spectrum: peaks at 448 ((M+H)+, 1 00%) ; 1 H NMR of the free base in CDCI 3 δ (ppm): 1 .25 (br,4H), 1 .75 (br, 1 H), 2.1 5 (br, 2H), 2.24 (br, 2H), 2.60 (br, I H), 2.92 ( , 5H), 3.55 (br, I H), 4.85 (d, 1 H), 6.43 (d, J = 5.5Hz, 1 H), 7.1 9 (m,2H), 7.35 (dd, J = 2 and 9Hz, 1 H), 7.37(d, J = 2Hz, I H), 7.62 (d, J = 9Hz,1 H), 7.94 (d J = 2Hz, I H), 8.51 (d, J = 5.5Hz, 1 H). Example 89 trans-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -[2-(4-methoxy-phenyl)- ethyl]-cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using 4-methoxyphenethylamine. Yield: 48% of white crystals (from methanol/ether), m.p. 220°C ISP mass spectrum: peaks at 410 ((M+H)+, 1 00%); 1 H NMR of the free base in CDCI 3 , δ (ppm): 1 .29 (br,5H), 2.05 (br, 2H), 2.22 (br, 2H), 2.55 (br,1 H), 2.77 (m,2H), 2.88 (m, 2H), 3.50 (br,1 H), 3.80 (s, 3H), 4.77 (d, 1 H), 6.42 (d, J = 5.5 Hz, 1 H), 6.85 (d, J = 8.5 Hz, 2H), 7.1 4 (d, J = 8.5 Hz, 2H), 7.35 (dd, J = 2 and 9 Hz, 1 H), 7.61 (d, J = 9 Hz, 1 H), 7.94 (d, J = 2 Hz, 1 H), 8.52 (d, J = 5.5 Hz, 1 H). Example 93 trans-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -[2-(4-nitro-phenyl)-ethyl]- cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using 4-nitrophenethylamine. Yield: 50% of white crystals (from methanol/diethyl ether), m.p. 205°C. El mass spectrum: peaks at 424 (M+, 8%), 407 (M-OH, 100%), 288 (44%), 259 (72%), 1 79 (48%); 1 H NMR of the free base in CDCI 3 δ (ppm) 1 .3 (m, 4H), 2.06 (br, 2H), 2.25 (br, 2H), 2.56 (br, 1 H), 2.95 (m, 5H), 3.50 (br, I H), 4.78 (d, 1 H), 6.42 (d, J = 5.4 Hz,1 H), 7.38 (m, 3H), 7.61 (d, J = 9 Hz,1 H), 7.95 (d, J = 2 Hz,1 H), 8.1 7 (d, 2H), 8.52 (d, J = 5.4 Hz, 1 H). Example 94 trans-Nι -(7-Chloro-quinolin-4-yl)-N 4 -[2-(3, 5-dimethoxy-phenyl)- ethyl]-cyclohexane-l ,4-diamine dihydrochloride Analogously to Example 88 using 3,5-dimethoxyphenethylamine. Yield: 45% of white crystals (from methanol/diethyl ether), m.p. 210°C. El mass spectrum: peaks at 439 (M+, 8%), 288 (100%), 259 (50%), 1 79 (20%); 1 H NMR of the free base in CDCI 3 δ (ppm): 1.32 (m, 4H), 2.06 (br, 2H), 2.25 (br, 2H), 2.56 (br, I H), 2.78 (m, 2H), 2.94 (m, 2H), 3.50 (br, 1 H), 3.79 (s, 6H), 4.78 (d, 1 H), 6.40 (m, 4H), 7.26( dd, J = 2 and 9 Hz, I H), 7.61 (d,J = 9Hz, I H), 7.95 (d, J = 2Hz, I H), 8.52 (d, J = 5.4 Hz, 1 H). Example 95 trans-Nι -( 2-Benzo[ 1 ,3 ]dioxol-5-yl-ethyl)-N 4 -(7-chloro-quinolin-4- yl)-cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using 3,4-methylenedioxyphenethyl- amine. Yield: 59% of white crystals (from methanol/diethyl ether), m.p. 21 5°C. El mass spectrum: peaks at 423 (M+, 8%), 388 (M-CI, 8%), 288 (100%), 259 (68%); 1 H NMR of the free base in CDCI 3 δ (ppm): 1 .3 (m, 5H), 2.06 (br, 2H), 2.25 (br, 2H), 2.56 (br, I H), 2.74 (m, 2H), 2.87 (m, 2H), 3.48 (br, I H), 4.78 (d, 1 H), 5.94 (s, 2H), 6.43 (d, J = 5.4 Hz, 1 H),6.42 (m, 3H), 7.22 (m, 4H), 7.35 (dd, J = 2 and 9 Hz, I H), 7.61 (d, J = 9 Hz,l H), 7.95 (d, J = 2 Hz, 1 H), 8.52 (d, J = 5.4 Hz, 1 H). S Example 96 trans-N τ[2-( 3-Chloro-phenyl)-ethyl]-N 4 -(7-chloro-quinolin-4- yl)-cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using 2-(3-chlorophenyl)ethylamine. Yield: 57% of white crystals (from methanol/diethyl ether), m.p. 249°C. El mass spectrum: peaks at 41 4 (M+, 5%), 288 ( 1 00%), 259 (48%); 1 H NMR of the free base in CDCI 3 δ (ppm): 1 .0-1 .5 (m, 4H), 2.07 (br, 2H), 2.23 (br, 2H), 2.55 (br, I H), 2.80 (m, 2H), 2.90 (m, 2H), 3.50 (br, 1 H), 4.78 (d, 1 H), 6.43 (d, J = 5.4 Hz, 1 H), 7.1 1 (m, 1 H), 7.22 (m, 4H), 7.35 (dd, J = 2 and 9 Hz, 1 H), 7.62 (d, J = 9 Hz, 1 H), 7.95 (d, J = 2 Hz, 1 H), 8.52 (d, J = 5.4 Hz, 1 H). Example 97 trans-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -[2-(2,5-dimethoxy-phenyl)- ethyl]-cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using 2,5-dimethoxyphenethylamine. Yield: 46% of white crystals (from methanol/diethyl ether), m.p. 227 0 C. El mass spectrum: peaks at 439 (M+, 8%), 288 ( 1 00%), 259 (84%), 1 52 (92%); 1 H NMR of the free base in CDCI 3 δ (ppm): 1 .2-1 .6 (m,5H), 2.08(br,2H), 2.25(br,2H), 2.58(br, 1 H), 2.84(m,4H), 3.50(br, 1 H), 3.77(s,3H), 3.79(s,3H), 4.78(d,1 H), 6.43(d,J=5.4Hz,1 H), 6.77(m,3H), 7.36(dd,J=2 and 9Hz,l H), 7.60(d,J=9Hz,1 H), 7.95(d,J=2Hz,1 H), 8.52(d,J=5.4Hz, 1 H). Example 98 trans-N 1 -(7-Chloro-quinolin-4-yl)-N 4 - [2-(4-phenoxy-phenyl)- ethyl]-cyclohexane-1 ,4-diamine dihydrochloride 5 Analogously to Example 88 using 4-phenoxyphenethylamine. Yield: 53% of white crystals (from methanol/diethyl ether), m.p. >250°C El mass spectrum: peaks at 471 ((M-H)+, 2%), 288 ( 100%), 259 o (44%); 1 H NMR of the free base in CDCI 3 δ (ppm): 1 .35 (m, 4H), 1 .55 (br, I H), 2.1 0 (br, 2H), 2.25 (br, 2H), 2.64 (br,1 H), 2.84 (m, 2H), 2.96 (m, 2H), 3.50 (br, I H), 4.84 (d, 2H), 6.43 (d, J = 5.5, 1 H), 6.9-7.4 (m, 1 0 H), 7.72 (d, J = 9, 1 H), 7.96 (d, J = 2, 1 H), 8.52 (d, J = 5.4, I H). 5 Example 99 trans-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -[2-(3 ,4-dichloro-phenyl)- ethyl]-cyclohexane- l ,4-diamine dihydrochloride 0 Analogously to Example 88 using 3,4-dichlorophenethylamine. Yield: 20% of white crystals (from methanol/diethyl ether), m.p. >250°C ISP mass spectrum: peaks at 450.2 ((M+H)+, 1 0%), 276.3 (23%), 5 225.9 (1 00%); 1 H NMR of the free base in DMS0-d6 δ (ppm): 1 .63 (br, 4H), 2.00 (br, 2H), 2.20 (br, 2H), 3.0-3.4 (m, 5H), 3.8 (br, I H), 7.06 (d, J = 7 Hz, I H), 7.28 (dd, J = 2 and 8 Hz, 1 H), 7.61 (m, 2H), 7.76 (dd, J = 2 and 1 0 Hz, 1 H), 8.08(d, J = 2 Hz, 1 H), 8.54 (d, J = 7 Hz, 1 H), 8.76 (d J = 1 0 Hz, 1 H), 9.08 (d, J = 8 Hz, 1 H), 9.34 (br, 2H), 0 14.4 (br, I H). Example 100 trans N 1 -(7-Chloro-quinolin-4-yl)-N 4 -(4-methoxy-benzyl)- 5 cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using 4-methoxybenzylamine. Yield: 20% of beige crystals (from methanol/ether). M.p. >250°C. 5c. ISP mass spectrum: peaks at 396 ((M+H)+, 85%), 276 (100%) ; 1 H- NMR in DMSO-de, δ (ppm): 1.50 (br, 4H), 2.20 (br, 4H), 3.1 0 (br, I H), 3.60 (br, I H), 3.77 (s, 3H), 4.10 (br, 2H), 6.62 (d, J = 7.5 Hz, 1 H), 7.00 (d, J = 10 Hz, 2H), 7.1 5 (d, 1 H), 7.46 (dd, J = 2 and 1 2 Hz, 1 H), 7.51 (d, J = 1 0 Hz, 2H), 7.60 (d, J = 2 Hz, 1 H), 8.37 (d, J = 1 2 Hz, I H), 8.40 (d, J = 7.5 Hz, I H). Example 101 trans-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -[2-(2,6-dichloro-phenyl)- ethyl]-cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using 2,6-dichlorophenethylamine. Yield: 38% of white crystals (from methanol-ether). m.p. >250°C. ISP mass spectrum: peaks at 448 (M+, 35%), 276 (35%), 225 ( 1 00%); 1 H-NMR of the free base in DMSO-d 6 , δ (ppm): 1 .46 (br, 4H), 2.1 1 (br, 4H), 2.99 (m, 3H), 3.21 (br, 4H), 3.55 (br, I H), 6.58 (d, J = 5.5 Hz, 1 H), 7.02 (d, 1 H), 7.33 (t, J = 8.5, Hz, 1 H), 7.44 (dd, J = 2 and 9 Hz, 1 H), 7.50 (d, J = 8.5 Hz, 2H), 7.77 (d, J = 2 Hz, 1 H), 8.35 (d, J = 9 Hz, 1 H), 8.39 (d, J = 5.5 Hz, I H). Example 102 trans N 1 -(7-Chloro-quinolin-4-yl)-N 4 -(3,4-dichloro-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using 3,4-dichlorobenzylamine. Yield: 50% of white crystals (from methanol/ether). M.ρ.>250°C. ISP mass spectrum: peaks at 434 (M+, 35%), 276 (100%); 1 H-NMR of the free base in DMS0-d 6 , δ (ppm): 1.32 (br, 4H), 1 .98 (br, 4H), 3.40 (br, 1 H), 3.80 (s, 2H), 6.53 (d, J = 5.5 Hz, 1 H), 6.90 (d, 1 H), 7.38 (dd, J = 2 and 9.5 Hz, 1 H), 7.41 (dd, J = 2 and 8 Hz, 1 H), 7.58 (d, J = 8 Hz, 1 H), 7.66 (d, J = 2 Hz, 1 H), 7.76 (d, J = 2 Hz, 1 H), 8.32 (d, J = 9.5 Hz, 1 H), 8.37 (d, J = 5.5 Hz, 1 H). 5 Example 103 trans-N] -Benzo[ 1 ,3 ]dioxol-5-ylmethyl-N 4 -(7-chloro-quinolin-4- yl)-cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using piperonylamine. Yield: 41 % of white crystals (from methanol/ether). M.p. >250°C. ISP mass spectrum: peaks at 41 0 ((M+H)+, 35%), 278 (55%), 276 ( 1 00%); 1 H-NMR of the free base in CDCI 3 δ (ppm): 1 .34 (br, 4H), 2.08 (br, 4H), 2.60 (br, I H), 3.55 (br, I H), 3,77 (s, 2H), 4.80 (d, 1 H), 5.95 (s, 2H), 6.43 (d, J = 5.5 Hz, 1 H), 6.81 (br, 4H), 7.35 (dd, J = 2 and 9 Hz, 1 H), 7.61 (d, J = 9 Hz, 1 H), 7.94 (d, J = 2 Hz, 1 H), 8.52 (d, J = 5.5 Hz, 1 H). Example 104 trans-4-{2-[4-(7-Chloro-quinolin-4-ylamino)-cyclohexylamino]- ethyl}-2-methoxy-phenol dihydrochloride Analogously to Example 88 using 4-hydroxy-3-methoxyphenethyl- amine. Yield: 14% of beige crystals (from methanol/ether). M.p.: 209°C. ISP mass spectrum: peaks at 426 (M + , 100%), 428 (M+2H+, 35%); 1 H-NMR of the free base in DMSO-d 6 , δ (ppm): 1 .50-2.00 (m, 8H), 2.65 (br, 2H), 2.70-3.00 (m, 3H), 3.60 (br, I H), 3.74 (s, 3H), 6.50 (d, J = 5.5 Hz, 1 H), 6.61 (dd, J = 2 and 8 Hz, 1 H), 6.68 (d, J = 8 Hz, 1 H), 6.78 (d, J = 2 Hz, 1 H), 6.85 (d, 1 H), 7.42 (dd, J = 2 and 9 Hz, 1 H), 7.76 (d, J = 2 Hz, 1 H), 8.37 (d, J = 5.5 Hz, 1 H), 8.40 (d, J = 9 Hz, I H), 8.72 (s, 1 H). GO Example 105 trans-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -[2-(2,3-dimethoxy- phenyl)-ethyl]-cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using 2,3-dimethoxyphenethylamine. Yield: 25% of beige crystals (from methanol/ether). M.p: 284°C. ISP mass spectrum: peaks at 440 (M + , 1 00%), 442 (M+2H+, 35%); 1 H-NMR of the free base in CDCI 3 δ (ppm): 1 .85 (br, 4H), 2.1 0 (br, 2H), 2.30 (br, 2H), 2,65 (br, 1 H), 2.96 (br, 4H), 3.49 (br, I H), 3.85 (s, 3H), 3.87 (s, 3H), 4.80 (d, I H), 6.44 (d, J = 6 Hz, 1 H), 6.85 (m, 2H), 7.02 (m, 1 H), 7.35 (dd, J = 2 and 10 Hz, 1 H), 7.62 (d, J = 10 Hz, I H), 7.95 (d, J = 2 Hz, 1 H), 8.53 (d, J = 6 Hz, I H). Example 106 trans-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -(3 , 5-dimethoxy-benzyl)- cyclohexane-1 ,4-diamine Analogously to Example 88 using 3,5-dimethoxybenzylamine. Yield: 50% of white crystals (from methylene chloride/ether). M.p:1 50oC ISP mass spectrum: peaks at 426(M + ,100%),428 (M+2H+, 55%); 1 H- NMR of the free base in CDCI 3 , δ (ppm): 1 .33 (br, 4H), 1 .99 (br, 4H), 3.45 (br, I H), 3.73 (s, 6H), 3.73 (s, 2H), 6.36 (m, I H), 6.53 (d, J = 5Hz, I H), 6.55 (d, 2H), 6.89 (d, I H), 7.41 (dd, J = 2 and 9 Hz, I H), 7.76 (d, J = 2 Hz), 1 H), 8.31 (d, J = 9 Hz, 1 H), 8.39 (d, J = 5 Hz, 1 H). Example 107 trans-N 1 -( 3-Chloro-benzyl)-N 4 -(7-chloro-quinolin-4-yl)- cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using 3-chlorobenzylamine. Yield: 50% of white crystals (from methanol/ether). M.p. > 280°C. (o l ISP mass spectrum: peaks at 400 (M + , 100%), 402 (M+2H+, 90%); 1 H-NMR of the free base in CDCI 3 , δ (ppm): 1.25 (m, 4H), 2.08 (br, 2H), 2.23 (br, 2H), 2.60 (br, 1H), 3.49 (br, 1H), 3.83 (s, 2H), 4.90 (d, IH), 6.44 (d, J = 5.5 Hz, IH), 7.25 (m, 3H), 7.35 (m, IH), 7.35 (dd, J = 2 and 9 Hz, IH), 7.62 (d, J = 9 Hz, IH), 7.95 (d, J = 2 Hz, IH), 8.51 (d, J = 5.5 Hz, IH). Example 108 trans N 1 -(7-Chloro-quinolin-4-yl)-N 4 -(2,4,6-trimethoxy-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using 2,4,6-trimethoxybenzylamine. Yield: 26% of white crystals (from methanol/ether). M.p. 271 oc. ISP mass spectrum: peaks at 456 (M + , 100%), 458 (M+2H+, 35%); 1 H-NMR of the free base in CDCI3, δ (ppm): 1.32 (br, 4H), 2.08 (br, 2H), 2.25 (br, 2H), 2.48 (br, 1H), 3.48 (br, IH), 3.81 (s, 9H), 3.81 (s, 2H), 4.78 (d, IH), 6.13 (m, 3H), 6.44 (d, J = 5.5 Hz, 1H), 7.34 (dd, J = 2 and 9 Hz, 1 H), 7.60 (d, J = 9 Hz, 1 H), 7.94 (d, J = 2Hz, 1 H), 8.51 (d, J = 5.5 Hz, IH). Example 109 trans-Nι-(7-Chloro-quinolin-4-yl)-N 4 -(2,4-dichloro-beπzyl)- cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using 2,4-dichlorobenzylamine. Yield 53% of white crystals (from methanol/ether). M.p.232°C. ISP mass spectrum: peaks at 434 (M+, 100%), 436 ((M+2H)+, 85%); 1 H-NMR of the free base in DMS0-d 6 , δ (ppm): 1.23-1.50 (m, 4H), 1.98 (br, 4H), 2.48 (br, 2H), 3.50 (br, IH), 3.60 (s, 2H), 6.52 (d, J = 5.5 Hz, IH), 6.85 (d, 1H), 7.41 (d, J = 6.5 Hz, 1H), 7.42 (dd, J = 2 and 8.5 Hz, 1 H), 7.57 (d, J = 2 Hz,1 H), 7.61 (d, J = 6.5 Hz, 1 H), 7.75 (d, J = 2 Hz, IH), 8.33 (d, J = 8.5 Hz.lH), 8.36 (d, J = 5.5 Hz, IH). G2 Example 1 10 trans-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -(3 ,4-dimethoxy-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using veratrylamine. Yield 22% of white crystals (from methanol/ether). M.p. > 270°C ISP mass spectrum: peaks at 426 ((M+H)+, 100%); 1 H-NMR of the free base in CDCI 3 , δ (ppm): 1 .25-1 .50 (m, 4H), 2.10 (br, 2H), 2.28 (br, 2H), 2.60 (br,1 H), 3.49 (br, 1 H), 3.80 (s, 2H), 3.87 (s, 3H), 3.90 (s,3H), 4.80 (d,1 H), 6.44 (d, J = 5.5 Hz, 1 H), 6.84 (m, 2H), 6.91 (d, J = 2 Hz, 1 H), 7.35 (dd, J = 2 and 9 Hz, 1 H), 7.61 (d, J = 9 Hz, 1 H), 7.95 (d, J = 2 Hz, 1 H), 8.52 (d, J = 5.5 Hz, 1 H). Example 1 1 1 trans-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -(2,4-dimethoxy-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using 2,4-dimethoxybenzylamine. Yield 20% of white crystals (from methanol/ether). M.p. > 270°C. El mass spectrum: peaks at 426 (M+, 2%), 274 (1 00%), 1 51 (90%); " • H-NMR of the free base in DMS0-d 6 , δ (ppm): 1 .40 (m, 4H), 2.00 (br, 4H), 2.50 (br, I H), 3.48 (br, 1 H), 3.73 (s, 2H), 3.75 (s, 3H), 3.79 (s, 3H), 6.50 (m, 3H), 6.91 (d, I H), 7.24 (d, J = 8 Hz, 1 H), 7.42 (dd, J = 2 and 9.5 Hz, I H), 7.76 (d, J = 2 Hz, I H), 8.32 (d, J = 9.5 Hz, I H), 8.37 (d, J = 5 Hz, 1 H). Example 1 12 trans-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -(3,4, 5-trimethoxy- benzyl)-cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using 3,4,5-trimethoxybenzylamine. Yield 36% of white crystals(from methanol/ether). M.p. >250°C. ISP mass spectrum: peaks at 456 ((M+H)+, 100%); 1 H-NMR of the free base in CDCI 3 , δ (ppm): 1 .37 (br, 4H), 2.1 5 (br, 2H), 2.30 (br, 2H), 2.70 (br, I H), 3.50 (br, I H), 3.80 (s, 2H), 3.83 (s, 3H), 3.88 (s, 6H), 4.80 (d, I H), 6.44 (d, J = 5.5 Hz, I H), 6.58 (s, 2H), 7.35 (dd, J = 2 and 1 0 Hz, 1 H), 7.62 (d, J = 1 0 Hz, 1 H), 7.95 (d, J = 2 Hz, 1 H), 8.52 (d, J = 5.5 Hz, I H). Example 1 13 trans-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -(4-dimethylamino-benzyl)- cyclohexane-1 ,4-diamine trihydrochloride Analogously to Example 88 using 4-dimethylamino-benzylamine. Yield 20% of beige crystals (from methanol/ether). Dec. from 240 O C. ISP mass spectrum: peaks at 409 ((M+H)+, 75%), 276 (75%); 1 H- NMR of the free base in CDCI 3 , δ (ppm): 1 .25-1 50 (m, 4H), 2.20 (br, 4H), 2.60 (br, I H), 2.93 (s, 6H), 3.50 (br, I H), 3.76 (s, 2H), 4.80 (d, 1 H), 6.43 (d, J = 5.5 Hz, 1 H), 6.72 ( d, J = 9 Hz, 2H), 7.22 (d, J = 9 Hz, 2H), 7.35 (dd, J = 2 and 9 Hz, 1 H), 7.61 (d, J = 9 Hz, 1 H), 7.95 (d, J = 2 Hz, I H), 8.52 (d, J = 5.5 Hz, 1 H). Example 1 74 trans-N 1 -( 7-Chloro-quinolin-4-yl)-N 4 -(2,6-difluoro-benzyl)- cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using 2,6-difluorobenzylamine. Yield 42% of white crystals (from methanol/ether). M.p. 262°C. ISP mass spectrum: peaks at 402 ((M+H)+, 1 00%), 276 (95%), 202 (7 2 (M+2H) 2+ ; 95%); 1 H-NMR of the free base in CDCI3, δ (ppm): 1 .35 (m, 4H), 1 .75 (br.l H), 2.10 (br, 2H), 2.25 (br, 2H), 2.55 (br, I H), 3.49 (br, I H), 3.95 (s, 2H), 4.84 (d,br, I H), 6.44 (d, J = 5.5 Hz, 1 H), 6.70 (m, 2H), 7.25 (m, I H), 7.35 (dd, J = 2 and 9 Hz, 1 H), 7.61 (d, J = 9 Hz, I H), 7.95 (d, J = 2 Hz, 1 H), 8.51 (d, J = 5.5 Hz, I H). <D Example 1 15 trans-N 1 -(7-Chloro-quinolin-4-yl)-N 4 -( 2-pyridin-2-yl-ethyl)- cyclohexane-1 ,4-diamine trihydrochloride Analogously to Example 88 using 2-(2-aminoethyl)-pyridine. Yield 26% of white crystals (from methanol/ether). M.p. 225°C. El mass spectrum: peaks at 380 (M+, 20%), 288 (20%), 259 (35%), 1 79 (85%), 93 (1 00%); 1 H-NMR of the free base in CDCI 3) δ (ppm): 1 .21 -1 .43 (m, 4H), 2.09 (br, 2H), 2.22 (br, 2H), 2.60 (br, I H), 3.04 (AB system, 4H), 3.50 (br, 1 H), 4.81 (d, br, I H), 6.43 (d, J = 5.5 Hz, 1 H), 6.92 ( d, J = 9 Hz, 2H), 7.21 (m, 2H), 7.35 (dd, J = 2 and 9 Hz, I H), 7.60 (m, 1 H), 7.95 (d, J = 2 Hz, I H), 8.52 (d, J = 9 Hz, 1 H), 8.55 (d, J = 5.5 Hz, I H). Example 1 16 trans-Nτ( 1 H-Benzimidazol-2-ylmethyl)-N 4 -(7-chloro-quinolin- 4-yl)-cyclohexane-l ,4-diamine trihydrochloride Analogously to Example 88 using (2-aminoethyl)-benzimidazole. Yield 22%o of white crystals (from methanol/ether). M.p. >250°C. ISP mass spectrum: peaks at 406 ((M+H)+, 55%), 276 (50%), 224 (35%), 204 (7 2 (M+2H) 2+ ; 100%); 1 H-NMR of the free base in d 6 - DMSO, δ (ppm): 1.18-1.50 (m, 4H), 2.01 (d, br, 4H), 3.64 (br, 1 H), 4.01 (s, 2H), 6.53 (d, J = 5.5 Hz, I H), 6.92 ( d, J = 9 Hz, 2H), 7.1 3 (m, 2H), 7.42 (dd, J = 2 and 9 Hz, 1 H), 7.50 (br, 1 H), 7.75 (d, J = 2 Hz, 1 H), 8.31 (d, J = 9 Hz, I H), 8.37 (d, J = 5.5 Hz, I H), 1 2.2 (br, I H). Example 1 17 trans-Nι -(7-Chloro-quinolin-4-yl)-N 4 -[2-( 1 H-indol-3-yl)-ethyl]- cyclohexane-1 ,4-diamine dihydrochloride Analogously to Example 88 using tryptamine. Yield 1 9% of white crystals (from methanol/ether). M.p. >250°C. (o5 ISP mass spectrum: peaks at 419 ((M+H)+, 40%), 276 (100%);^- NMR of the free base in d 6 -DMSO, δ (ppm): 1.12-1.50 (m, 4H), 1.99 (br, 4H), 3.08-3.64 (m, 4H), 4.42 (m, 2H), 6.51 (d, J = 5.5 Hz, IH), 6.88-7.12 (m, 3H), 6.72 ( d, J = 9 Hz, 2H), 7.17 (d, J = 2 Hz, IH), 7.33 (d, J = 8 Hz, 1H), 7.42 (dd, J = 2 and 9 Hz, IH), 7.52 (d, J = 7.5 Hz, 1H), 7.76 (d, J = 2 Hz, 1H), 8.31 (s, IH), 8.36 (d, J = 5.5 Hz, 1H), 10.80 (s, br,1H). The intermediates used in the foregoing Examples are in part accessible according to known and described procedures or can be prepared in the following manner: Example 118 (2R)-Nι -(7-Chloro-quinolin-4-yl)-l ,2-propane-diamine (starting material for Example 1 ) 2.9 g of (S)-2-amino-l-chloro-N-(7-chloro-quinolin-4-yl)- propane are held at 110°C/40 bar in 30 ml of methanol and 30 ml of liquid ammonia in a bomb tube for 20 hrs. After cooling the ammonia is carefully allowed to evaporate and the residue is then poured into 100 ml of saturated sodium chloride solution and extracted twice with 100 ml of dichloromethane. The organic phase is dried over sodium sulphate and evaporated. The crude product is chromatographed on neutral aluminium oxide in dichloromethane/methanol 10:1 and then crystallized from dichloromethane/toluene. 1.9 g (80%) of (2R)-Nι-(7-chloro- chinolin-4-yl)-1 ,2-propane-diamine are obtained as white crystals; m.p. 145°C Example 119 (S)-N2-(7-Chloro-quinolin-4-yl)-1 ,2-propane-diaminedihydro- chloride (starting material for Example 2) (o^ Step 1 23 g of L-alaninol and 57.4 g of 4,7-dichloroquinoline are held at 1 50°C in 1 00 ml of 1 -methyl-2-pyrrolidone for 6 hrs. 5 After cooling the reaction mixture is poured into 500 ml of cold 2N HCI and extracted three times with 200 ml of dichloro¬ methane. The acidic-aqueous phase is made basic with 28% NaOH, with the product separating. After stirring in an ice bath for 30 min. the product is filtered off and then recrystallized from i o 300 ml of 2-ρropanol/1 50 ml of ethanol. There are obtained 51 .2 g (74%) of (S)-2-amino-N-(7-chloro-quinolin-4-yl)-1 - propanol; white crystals, m.p. 225°C, [α]p = +35° (c = 1.0, MeOH). 1 H-NMR (250MHz) in d6-DMS0, signals at δ (ppm): 1 .24 (d, J = 6.4 1 5 Hz, 3H), 3.45 ( , 1 H), 3.58 (m, 1 H), 3.73 (m, 1 H), 4.87 (t, J = 5.6 Hz, 1 H), 6.53 (d, J = 7 Hz, 1 H), 6.84 (d, J = 7.7 Hz, 1 H), 7.44 (dd, J = 2 and 9 Hz, 1 H), 7.78 (d, J = 2 Hz, 1 H), 8.35 (d, J = 7 Hz, 1 H), 8.39 (d, J = 9 Hz, I H). 20 Step 2 2.7. g of (S)-2-amino-N-(7-chloro-quinolin-4-yl)-l - propanol are suspended in 270 ml of chloroform. Then, a solution of 72 ml of thionyl chloride in 70 ml of chloroform is added 25 dropwise thereto while cooling with ice over 30 min., during which the temperature should not exceed 25°C. Subsequently, the mixture is stirred at room temperature for a further 30 min. and at 70°C for 90 min. The reaction mixture is cooled and evaporated, then treated with toluene and again evaporated. The 30 resulting foam is dissolved in 500 ml of ethanol while warming, filtered and concentrated to about 300 ml, whereupon crystal¬ lization occurs. There are obtained 31.6 g (94%) of (S)-2-amino- 1 -chloro-N-(7-chloro-quinolin-4-yl)-propanehydrochloride; m.p. 210°C, [α]D = +90° (c = 1.0, MeOH). 35 1 H-NMR (250MHz) in d6"DMS0, signals at δ (ppm): 1 .41 (d, J = 6.5 Hz, 3H), 3.88-4.06 (m, 2H), 4.48 (m, 1 H), 7.03 (d, J = 7.3 Hz, 1 H), 7.79 (dd, J = 2 Hz and 9 Hz, 1 H), 8.1 5 (d, J = 2 Hz, 1 H), ( ol 8.59 (d, J = 7.3 Hz, 1 H), 8.89 (d, J = 9 Hz 1 H), 9.44 (d, J = 8.4 Hz, I H), 14.66 (s, I H). Step 3: 7.1 g of (S)-2-amino-N-(7-chloro-quinolin-4-yl)-1 - propanol are suspended in 70 ml of dichloromethane ander argon, treated with 6.2 ml of triethylamine and then cooled in ice. 3.2 ml of methanesulphonyl chloride are added dropwise thereto at 5°C over 1 0 min. and the mixture is left to warm for 1 h., diluted with 70 ml of dichloromethane and extracted twice with 1 00 ml of water. After drying and evaporation the crude product is dissolved in 70 ml of N,N-dimethylformamide and stirred at 70°C with 2 g of sodium azide for 3 h. After cooling the mixture is extracted twice with 200 ml of ethyl acetate and twice with 200 ml of water. The crude product is chromatographed on silica gel in ethyl acetate and crystallized from 1 5 ml of hot ethyl acetate and 30 ml of hexane. There are obtained 4.3 g (55%) of (S)-2-amino-1 -azido-N-(7-chloro-quinolin-4-yl)-propane; white crystals, m.p. 1 37°C, [α]D = +1 30o (c = 1.0, MeOH). I H-NMR (250MHz) in d6-CDCl3, signals at δ (ppm): 1 .41 (d, J = 6.5 Hz, 3H), 3.49-3.65 (m 2H), 3.96 (m, 1 H), 5.00 (d, J = 10 Hz, 1 H), 6.44 (d, J = 7.3 Hz, 1 H), 7.38 (dd, J = 2 Hz and 9 Hz, 1 H), 7.68 (d, J = 9 Hz, 1 H), 7.97 (d, J = 2 Hz, 1 H), 8.56 (d, J = 7.3 Hz, I H). Step 4: 2 g of (S)-2-amino-1 -azido-N-(7-chloro-quinolin-4-yl)- propane are dissolved in 38 ml of methanol, then 5.3 ml of triethylamine and 3.8 ml of propane-1 ,3-dithiol are added and the mixture is stirred at room temperature for 72 hrs. The reaction mixture is evaporated and dried in a high vacuum for a further 4 h. For crystallization, the resulting oil is triturated with 1 5 ml of toluene. 0.98 g (54%) of white crystals, m.p. I I 3°C, is obtained. For the preparation of the hydrochloride, 0.5 g of free base is dissolved in 1 0 ml of acetone and then 8 treated with 2.3 ml of 2N HCI. There is obtained 0.63 g (96%) (S)-N2-(7-chloro-quinolin-4-yl)- 1 , 2-propanediamine-di hydro¬ chloride; white crystals; m.p. 21 0°C, [α]D = +1 04° (c = 1.0, MeOH). 1 H-NMR (250MHz) in d6-DMS0, signals at δ (ppm): 1.38 (d, J = 6.5 Hz, 3H), 3.1 6 ( , I H), 3.36 (m, I H), 4.51 (m, I H), 7.01 (d, J = 7 Hz, I H), 7.76 (dd, J = 2 Hz and 9 Hz, I H), 8.52 (m, 3H), 8.61 (d, J = 7 Hz, 1 H), 8.97 (d, J = 9 Hz, 1 H), 9.47 (d, J = 9 Hz, 1 H), 1 4.7 (br. s, I H). Example 120 N i -(7-Chloro-quinolin-4-yl)-2-methyl-propane-1 , 2-diamine (starting material for Examples 3-59). 1 98 g of 4,7-dichloroquinoline, 97 g of 1 ,2-diamino-2- methylpropane and 101 g of triethylamine are stirred in 1 I of N-methyl-2-pyrrolidone at 1 50°C ander argon for 5 hours. Then, the solvent is evaporated in a vacuum and the residue is taken up in 1 I of water. The pH is adjusted to 1 using 220 ml of 25% hydrochloric acid and the mixture is diluted with 6 I of water and extracted four times with 0.5 I of ethyl acetate each time. Then, the clear aqueous solution is treated with about 900 g of KOH, whereby the pH rises to 14 and the product separates in crystalline form. This is filtered off ander suction, rinsed with about 3 I of water and, for further purification, recrystallized from 4 I of acetonitrile. There are obtained 1 26.7 g (73%) of Ni - (7-chloro-quinolin-4-yl)-2-methyl-propane-1 ,2 -diamine, m.p. 1 82-1 84°C. 1H-NMR in CDCI 3 , δ (ppm): 1 .25 (m, 2H), 1 .28 (s, 6H), 3.08 (d, J = 5 Hz, 1 H), 6.37 (d, J = 6 Hz, 1 H), 7.37 (dd, J = 2 Hz and 8 Hz, 1 H), 7.76 (d, J = 8 Hz, 1 H), 7.95 (d, J = 2 Hz, 1 H), 8.51 (d, J = 6 Hz, I H). f Example 121 ( 1 S,2S)-N ι -(7-Chloro-quinolin-4-yl)-cyclohexane- 1 ,2-diamine (starting material for Examples 60-67) 1 3.6 g of (1 S,2S)-(+)-1 ,2-diaminocyclohexane, 23.6 g of 4,7-dichloroquinoline and 1 6.6 ml of triethylamine are held at 1 50°C in 1 50 ml of 1 -methyl-2-pyrrolidone ander argon for 1 6 hrs. Then, the solvent is largely distilled off at 0.1 Torr/ 80°C and the residue is triturated with 300 ml of 1 .5N HCI. The resulting aqueous suspension is extracted three times with 300 ml of dichloromethane and then made basic with concen¬ trated ammonia, with gum-like clumps separating. The super¬ natant solution is decanted off and extracted twice with 400 ml of dichloromethane. The crude product obtained from these extracts is purified by two-fold flash chromatography on neutral aluminium oxide (Brockmann activity II) with dichloromethane and dichloromethane/ethanol 30:1 . Crystallization is effected from 40 ml of dichloromethane and 60 ml of ethyl acetate by distillation of the former. Yield: 4 g ( 1 2%) of (1 S,2S)-N-(7- chloro-quinolin-4-yl)-cyclohexane-1 ,2-diamine; m.p. 1 60°C, [α]D = +1 29.3° (MeOH, c = i .fj). Example 122 cis-N i -(7-Chloro-quinolin-4-yl)-cyclopentane- 1 ,3-diamine (starting material for Example 68) 29.5 g of cyclopentane-1 ,3-diamine dihydrobromide [prepared according to 0. Diels, J.H. Blom and W. Knoll, Liebigs Ann. 443, 242 (1 925)] are held for 6 hours in a heating bath at 1 80°C together with 1 9.8 g of 4,7-dichloroquinoline and 27.8 ml of triethylamine in 1 00 ml of 1 -methyl-2-pyrrolidone. The cooled reaction mixture is poured into 1 I of water and the pH of the mixture is adjusted to 7 using 1 0% aqueous KOH. The mixture is extracted firstly with 5 0.5 I portions of ethyl acetate, the pH is increased to 1 2 using KOH and the mixture is again extracted with 3 0.5 I portions of ethyl acetate. The latter extract gives, after evaporation of the solvent, 29.9 g of a crude product which, for further purification, is chromatographed on 500 g of silica gel with a dichloromethane-methanol mixture in the ratio by volume 97:3. After a fore-run of 2.5 I, which consists of a mixture of the product with byproducts, there is obtained in the subsequent 3.75 I of eluate, an almost pure product which, after evaporation of the solvent, is obtained as a yellow oil and which, as such, can be used for the further reactions. Yield: 5.1 g of cis- N-(7-chloro-quinolin-4-yl)-cyclopentane-l ,3 -diamine 1 H-NMR in DMS0-d 6 , δ (ppm): 1 .44 (m, 2H), 1.71 - 2.1 3 (m, 5H), 2.22 (quint., J = 6.9 Hz, 1 H), 3.34 (m, 1 H), 3.97 (m, 1 H), 6.46 (d, J = 6 Hz, I H), 7.30 (d, J= 7.5 Hz), 7.44 (dd, J = 2 Hz and 9 Hz, 1 H), 7.77 (d, J = 2 Hz, 1 H), 8.26 (d, J = 9 Hz, 1 H), 8.39 (d, J = 6 Hz, 1 H). Example 123 cis-N i -(7-Chloro-quinolin-4-yl)-cyclohexane-1 ,4-diamine (starting material for Examples 69-87) Step 1: trans-N-( 7-Chloro-quinolin-4-yl)-4-aminocyclohexanol 41 4.2 g of 4,7-dichloroquinoline, 380 g of trans-4-amino- cyclohexanol hydrochloride and 255 g of triethylamine are heated to reflux overnight in 1 .05 I of 1 -methyl-2-pyrrolidone ander an argon atmosphere. After cooling the reaction mixture 3.8 I of water and 380 ml of 28% sodium hydroxide solution are added thereto while stirring and cooling. The separated reaction product is filtered off ander suction, washed with water until the wash water is neutral and dried at 1 00°C/1 2 bar. Yield 491 g (84.9%) of trans-N-(7-chloro-quinolin-4-yl)-4-aminocyclo- hexanol. 1 \ Step 2: trans-N-(7-Chloro-quinolin-4-yl)-4-methanesulphonyloxy-cyclo- hexylamine 447 ml of methanesulphonyl chloride are added portionwise within 20 minutes while cooling with an ice bath to a mixture of 1 1 57 g of trans-N-(7-chloro-quinolin-4-yl)-4-aminocyclohexanol and 868 ml of triethylamine in 6.1 I of dichloromethane. After a clear solution has formed transiently the product begins to separate. After 2 hours the mixture is filtered and the filtrate is evaporated to dryness. Filter residue and evaporation residue are combined and triturated in 8 I of water. The mixture is again filtered, washed with a further 8 I of water and thereafter with 4 I of isopropanol and the product obtained is dried at 50°C/ 1 2 mbar. Yield: 2028 g (90%) of trans-N-(7-chloro-quinolin-4- yl)-4-methanesulphonyloxy-cyclohexylamine, m.p.: 1 54-1 59°C. Step 3: cis-N-(7-Chloro-quinolin-4-yI)-cyclohexyl- 1 ,4-di amine 433 g of trans-N-(7-chloro-quinolin-4-yl)-4-methane- sulphonyloxy-cyclohexylamine are reacted at 80°C for 1 0 hours with 80.7 g of sodium azide in 2.1 6 I of N,N-dimethylformamide. After cooling to room temperature 2.36 I of ethyl acetate and 2 I of water are added thereto in succession, the pH is adjusted to 9 by the addition of 28% sodium hydroxide solution and the phases are left to separate. The aqueous phase is back-extracted a further seven times with 0.5 I of ethyl acetate each time. The pooled ethyl acetate extracts are combined and evaporated. The evaporation residue crystallizes after the addition of 0.5 I of n-hexane. It is filtered off ander suction and dried at 40°C/ 1 2 mbar. The thus-obtained crude product (256 g) consists to 78% of trans-N-(7-chloro-quinolin-4-yl)-4-azido-cyclohexyl- amine (corresponding to 1 92 g, 53%) in addition to 1 8% of an elimination product and 7% of unreacted trans-N-(7-chloro- quinolin-4-yl)-4-methanesulphonyloxy-cyclohexylamine. 12. 220 g of this crude product are suspended in 2.5 I of isopropanol. 203 ml of triethylamine, 7.24 ml of 1 ,3-propane- dithiol and 54.8 g of sodium borohydride are added thereto in succession and the mixture is warmed to 40°C while stirring. After 1 6 hours a further 54.5 g of sodium borohydride are added thereto. After a total reaction period of 40 hours the mixture is cooled using an ice bath and excess hydride is decomposed by the slow addition of 1 80 ml of glacial acetic acid. After the hydrogen evolution has died away the reaction mixture is evaporated on a rotary evaporator. Then, 0.3 I of methanol is added thereto and the mixture is again evaporated. Addition of methanol and evaporation are repeated a total of 5 times with 0.3 I portions each time. Thereafter, the residue is taken up in 3 I of 3N sodium hydroxide solution and extracted three times with 1 I of dichloromethane each time. The combined dichloro¬ methane phases are then extracted with 1 .5 I of water, with the aqueous phase being adjusted to pH 7 by the addition of about 2 I of 1 N hydrochloric acid. The extraction is repeated twice with 2 I of water/dil. hydrochloric acid while maintaining this pH. After combining the aqueous extracts the pH is adjusted to 1 2-1 3 using 28% sodium hydroxide solution and the product is extracted with 3 1 I portions of ethyl acetate. After evaporation of the solvent pure, crystalline cis-N-(7-chloro-quinolin-4-yl)-cyclo- hexyl-1 ,4-diamine remains behind in a yield of 1 28 g and can be used without further purification. It can be recrystallized from methanol-diethyl ether (20.6 g from 32 g of crude product in 50 ml of methanol and 400 ml of diethyl ether); m.p. 1 39-140°C. 1H-NMR in DMSO-d 6 , δ (ppm): 1 .65 (m, 6H), 1.89 (m, 2H), 3.05 (m, 1 H), 3.60 (m, 1 H), 3.75 (m, 2 H), 6.50 (d, J = 6.5 Hz, 1 H), 6.84 (d, J = 7 Hz, 1 H), 7.44 (dd, J = 2 Hz and 8.5 Hz, 1 H), 7.78 (d, J = 2 Hz, 1 H), 8.38 (d, J = 6.5 Hz, 1 H), 8.42 (d, J = 8.5 Hz, 1 H). Example 124 4-(7-Chloro-quinolin-4-ylamino)-cyclohexanone Starting material for Examples 88-1 1 7 and analogues. 1 3.6 g of trans-4-(7-chloro-quinolin-4-ylamino)- cyclohexanol (Example 1 23, step 1 ) are dissolved in 100 ml of dimethyl sulphoxide and 68 ml of triethylamine and cooled to + 1 0°C under argon. A solution of 25.5 g of sulphur trioxide- pyridine complex in 100 ml of dimethyl sulphoxide is added dropwise in such a manner that the internal temperature does not exceed +1 5°C After stirring for an additional 90 minutes 800 ml of water are rapidly added dropwise. The emulsion obtained becomes a filterable suspension after vigourous stirring at +1 0°C. The filter material is recrystallized from ethanol- ether. Yield: 10.1 g (75%) of beige crystals; dec. 195°C. El mass spectrum: peaks at 274 (M + , 65%), 21 7 (100%). 1 H-NMR in DMSO-d6, δ (ppm): 1.85 (m, 2H), 2.25 (m, 4H), 2.60 (m, 2H), 4.06 (m, 1 H), 6.68 (d, J = 7.5 Hz,1 H), 7.05 (d, J = 9Hz,1 H), 7.46 (dd, J = 2 andl 0 Hz, 1 H), 7.79 (d, J = 2 Hz, 1 H), 8.36 (d, J = 1 0 Hz, 1 H), 8.44 (d, J = 9 Hz, 1 H). Any of the compounds described in the foregoing can be formulated as the active ingredient according to methods known per se to give pharmaceutical preparations of the following composition: 1 . 500 mα tablets 700 mg 2. 50 mα tablets 300.0 mg 4. 500 mα suppositories Active ingredient 500 mg Suppository mass ad 2000 mg 5. 1 00 mg soft gelatine capsules Active ingredient 100 mg Medium chain triglyceride 300 mα 400 mg 15

Claims: Clai m s 1. N ι -Aralkyl-N2-quinolin-4-yl-diamine derivatives of the general formula (CH 2 ) p wherein Ri signifies halogen or trifluoromethyl; R2 signifies hydrogen, halogen or trifluoromethyl; A signifies or (C 5 -C 6 )-cycloalkylene; n signifies 1 -4; R 3 and R 4 each independently signify hydrogen or methyl; p signifies 0-3 and B signifies aryl, as well as pharmaceutically acceptable salts of basic compounds of general formula I. 2. Compounds according to claim 1 , wherein p signifies 1 -3. 3. Compounds according to claim 1 or claim 2, wherein aryl signifies phenyl or substituted phenyl, with the number of substituents preferably being 1 -3 and the substituents being selected from a group consisting of halogen, hydroxy, lower- alkyl, lower-alkoxy, trifluoromethyl, cyano, di-lower-alkyl- amino or their N-oxides, phenyloxy, phenyl or methylsulphanyl, or wherein aryl signifies naphthyl, benzop ,3]diol or a bicyclic aromatic heterocycle with 1 or 2 hetero atoms, especially N and/or 0, for example pyridyl, quinolyl or furyl. 4. Compounds according to any one of claims 1 to 3, wherein R 1 signifies chlorine, R 2 signifies hydrogen, p signifies 1 l h or 2, A signifies -CH2C(CH3)2- and B signifies a benzene ring which is mono-, di- or tπ-substituted. 5. N ι -(7-Chloro-quιnolιn-4-yl)-N2-(3-chloro-benzyl)-2- methyl-propane-1 ,2-dιamιne, N ι -(7-chloro-quιnolιn-4-yl)-N2-( benzyl) -2-methyl- propane-1 ,2-dιamιne, N ι -(7-chloro-quιnolιn-4-yl)-N2-(2-hydroxy-3-methoxy- benzyl)-2-methyl-propane-1 ,2-diamιne, N i -(7-chloro-quιnolιn-4-yl)-N2-(2-hydroxy-5-methoxy- benzyl)-2-m ethyl-propane- 1 ,2-dιamιne, Nι -(7-chloro-quιnolιn-4-yl)-N2-(4-hydroxy-3-methoxy- benzyl)-2-methyl-propane-1 ,2-dιamιne, trans-Nτ(7-chloro-quιnolin-4-yl)-N4-[2-(3 , 5-dιmethoxy- phenyl)-ethyl]-cyclohexane-1 ,4-diamιne, cιs-N ι -(7-chloro-quιnolιn-4-yl)-N4-(4-methoxy-benzyl)- cyclohexane-1 ,4-dιamιne, trans-Nι -(7-chloro-quιnolιn-4-yl)-N4-(4-dιmethylamιno- benzyl)-cyclohexane-1 ,4-diamιne and trans-Nτ(7-chloro-quιnolιn-4-yl)-N4-(2,6-dιfluoro- benzyl)-cyclohexane-1 ,4-dιamιne. 6. Compounds according to any one of claims 1 to 3, wherein R 1 signifies chlorine, R 2 signifies hydrogen, p signifies 1 , A signifies cyclohexane-1 ,2-dιyl or cyclohexane-1 ,4-dιyl and B signifies a benzene ring which is unsubstituted or mono- or di- substituted. 7. ( 1 S,2S)-Nι -(7-Chloro-quιnoiιn-4-yl)-N 2 -(benzyl)- cyclohexane-1 ,2-diamιne, ( 1 S,2S)-Nι -(7-chloro-quιnolιn-4-yl)-N2-(4-chloro-benzyl)- cyclohexane-1 ,2-dιamιne, ( 1 S,2S)-N ι -(7-chloro-quιnoiιn-4-yl)-N2-(4-d i met hylami no- benzyl) -cyclohexane-1 ,2-dιamιne, cιs-N ι -(7-chloro-quιnolιn-4-yl)-N4-(4-dιmethylamιno- benzyl)-cyclohexane- l ,4-dιamιne, cιs-N ι -(7-chloro-quιnolιn-4-y I )-N4-( benzyl )-cyclohexan- 1 ,4-dιamιne, cis-Nι-(7-chloro-quinolin-4-yl)-N4-(3-chloro-benzyl)- cyclohexaπe-1 ,4-diamine, cis-N]-(7-chloro-quinoiin-4-yl)-N4-(2-hydroxy-4- methoxy-benzyl)-cyclohexane-1 ,4-diamine, cis-Nτ(7-chloro-quinolin-4-yl)-N4-(3,5-dimethoxy- benzyl)-cyclohexane-l ,4-diamine, cis-Nτ(7-chloro-quinolin-4-yl)-N4-(4-methylsulphanyl- benzyl)-cyclohexane-1 ,4-diamine, cis-Nι-(7-chloro-quinolin-4-yl)-N4-(4-diethylamino- benzyl)-cyclohexane-1,4-diamine and cis-Nι-(7-chloro-quinolin-4-yl)-N4-(biphenyl-4-ylmethyl)- cyclohexane-1 ,4-diamine. 8. A medicament, especially for the treatment or prevention of malaria, containing one or more compounds according to any one of claims 1-7 and a therapeutically inert excipient. 9. A process for the manufacture of compounds according to any one of claims 1-7, which process comprises a) reducing a Schiff's base of the general formula wherein the substituents have the significance described in claim 1, or b) reacting an amine of the formula m with a compound of the formula X - (CH 2 ) p -B IV wherein X signifies a leaving group and the other substituents have the significance described in claim 1 or c) reacting a compound of the formula with an amine of the formula H 2 N- (CH 2 ) p -B VI wherein all substituents have the significance described in claim 1 , or d) reacting a ketone or an aldehyde of the formula wherein Y signifies - ( o or oxo-(C 5 -C 6 )-cycloalkyl and R 1 and R 2 have the significance set forth in claim 1 , with an amine of formula VI and a reducing agent, and 7q e) if desired, converting the compound obtained into a pharmaceutically acceptable acid addition salt. 10. Compounds according to any one of claims 1 -7, insofar as they are manufactured by the process according to claim 9 or a process equivalent thereto. 1 1 . Compounds according to any one of claims 1 -7 for use as therapeutically active substances, especially as active substances against malaria. 12. The use of compounds according to any one of claims 1 -7 especially for the treatment or prevention of malaria or, respectively, for the production of corresponding medicaments. 13. The invention as hereinbefore described. * * * AMENDED CLAIMS [received by the International Bureau on 4 March 1997 (04.03.97); original claims 1-13 replaced by amended claims 1-12 (5 pages)] Nι-Aralkyl-N 2 -quinolin-4-yl-diamine derivatives of the general formula H (CH 2 ) p wherein RI signifies halogen or trifluoromethyl; R2 signifies hydrogen, halogen or trifluoromethyl; signifies or (C 5 -C 6 )-cycloalkylene; n signifies 1-4; R 3 and R 4 each independently signify hydrogen or methyl; p signifies 1-3 and B signifies aryl, as well as pharmaceutically acceptable salts of basic compounds of general formula I, with the proviso that when B is unsubstituted phenyl or phenyl, which is tri-substituted by lower-alkoxy, A does not signify -CH(CH3)-. 2. Compounds according to claim 1, wherein aryl signifies phenyl or substituted phenyl, with the number of substituents preferably being 1-3 and the substituents being selected from a group consisting of halogen, hydroxy, lower-alkyl, lower-alkoxy, trifluoromethyl, cyano, di-lower-alkyl- amino or their N-oxides, phenyloxy, phenyl or methylsulphanyl, or wherein aryl signifies naphthyl, benzo[l,31diol, pyridyl or furyl. 3. Compounds according to any one of claims 1 or 2, wherein R 1 signifies chlorine, R 2 signifies hydrogen, p signifies 1 or 2, A signifies -CH2C(CH 3 ) 2 - and B signifies a benzene ring which is mono-, di- or tri- substituted. SI 4. Nι-(7-Chloro-quinolin-4-yl)-N2-(3-chloro-benzyl ) -2-methyl-propane- 1,2- diamine, Nι-(7-chloro-quinolin-4-yl)-N2-(benzyl ) -2-methyl-propane-l,2-diaπ-ine, Nι-(7-chloro-quinolin-4-yl)-N2-(2-hydroxy-3-methoxy-benzyl)-2-methyl- propane-l,2-diamine, Nι-(7-chloro-quinohn-4-yl)-N2- ( 2-hydroxy-5-methoxy-benzyl)-2-methyl- propane-l,2-di amine, Nι-(7-chloro-quinolin-4-yl)-N2- ( 4-hydroxy-3-methoxy-benzyl)-2-methyl- propane- 1 ,2 - di amine , trans-Nι-(7-chloro-quinolin-4-yl)-N4-[2-(3,5-dimethoxy-phenyl)-ethyl]- cyclohexane-l,4-di amine, cis-Nι-(7-chloro-quinolin-4-yl)-N4-(4-methoxy-benzyl)-cyclohexane-l,4- diamine, trans-Nι-(7-cUoro-quinolin-4-yl)-N4-(4-dimethylamino-benzyl)- cyclohexane-l,4-diamine and trans-Nι-(7-chloro-quinoHn-4-yl)-N4-(2,6-difluoro-benzyl)-cyclohexane- 1,4-diamine. 5. Compounds according to any one of claims 1 or 2, wherein R 1 signifies chlorine, R 2 signifies hydrogen, p signifies 1, A signifies cyclohexane- 1,2-diyi or cyclohexane- 1,4-diyl and B signifies a benzene ring which is unsubstituted or mono- or di-substituted. 6. (lS,2S)-Nι-(7-Chloro-quinolin-4-yl)-N2-(benzyl)-cyclohexane-l,2- di ami e, (lS,2S)-Nι-(7-chloro-quinolin-4-yl)-N2-(4-chloro-benzyl)-cyclohexane-l,2- di amine, (lS,2S)-Nι-(7-chloro-quinolin-4-yl ) -N2-(4-dimethylamino-benzyl)-cyclo- hexane-l,2-diamine, cis-Nι-(7-chloro-quinolin-4-yl ) -N4- ( 4-dimethylaπιino-benzyl)-cyclohexane- 1,4-diamine, cis-Nι-(7-chloro-quinolin-4-yl)-N4-(benzyl)-cyclohexan-l,4-diamine, cis-Nι-(7-chloro-quinolin-4-yl)-N4-(3-chloro-benzyl)-cyclohexane-l,4- di amine, cis-Nι-(7-chloro-quinolin-4-yl)-N4-(2-hydroxy-4-methoxy-benzyl)-cyclo- hexane-l,4-diamine, cis-Nι-(7-chloro-quinolin-4-yl ) -N4- ( 3,5-dimethoxy-benzyl ) -cyclohexane- 1,4-diamine, cis-Nι-(7-chloro-quinolin-4-yl)-N4-(4-methylsulphanyl-benzyl)- cyclohexane- 1 ,4-diamine, cis-Nι-(7-chloro-quinolin-4-yl)-N4-(4-diethylamino-benzyl)-cyclohexane- 1,4-diamine and cis-Nι-(7-chloro-quinolin-4-yl)-N4-(biphenyl-4-ylmethyl)-cyclohexane-l,4- diamine. 7. A medicament, especially for the treatment or prevention of malaria, containing one or more compounds according to any one of claims 1-6 and a therapeutically inert excipient. 8. A process for the manufacture of compounds according to any one of claims 1-6, which process comprises a) reducing a SchifFs base of the general formula wherein the substituents have the significance described in claim 1, or b) reacting an amine of the formula with a compound of the formula X-(CH 2 ) p -B IV wherein X signifies a leaving group and the other substituents have the significance described in claim 1, or c) reacting a compound of the formula with an amine of the formula H 2 N- (CH 2 ) p -B VI wherein all substituents have the significance described in claim 1, or d) reacting a ketone or an aldehyde of the formula R 3 R 3 wherein Y signifies - ( C ) -c = o or oxo-(C 5 -C 6 )-cycloalkyl and R 1 and R 2 have the significance set forth in claim 1, with an amine of formula VI and a reducing agent, and e) if desired, converting the compound obtained into a pharmaceutically acceptable acid addition salt. 9. Compounds according to any one of claims 1-6, insofar as they are manufactured by the process according to claim 8 or a process equivalent thereto. 10. Compounds according to any one of claims 1-6 for use as therapeutically active substances, especially as active substances against malaria. 11. The use of compounds according to any one of claims 1-6 especially for the treatment or prevention of malaria or, respectively, for the production of corresponding medicaments. 12. The invention as hereinbefore described. *** <35

Inventors: HOFHEINZ WERNER, MASCIADRI RAFFAELLO, HOFHEINZ, WERNER, MASCIADRI, RAFFAELLO
Applicants: HOFFMANN LA ROCHE, F. HOFFMANN-LA ROCHE AG
Application year: 1996
Main classification: C07D215
IPC codes: A61K31, A61P33, C07D215, C07D401, C07D405