PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS

Abstract: The invention relates to compounds of formula (I) wherein Z, Rc, y, m, u, Ar2, n, X, Rc',(I) and Ar2 are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

Description: PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS BACKGROUND OF THE INVENTION The present invention relates to a genus of compounds useful as antagonists of neurokinin receptors. In particular, these can be neurokinin-1 receptor (NKi ) antagonists. Some can also be neurokinin-1 receptor (NKι)antagonists and neurokinin-2 receptor (NK2) antagonists, that is, NK-i / NK2 dual receptor antagonists. Some can also be neurokinin-2 receptor (NK2) antagonists. Some can also be neurokinin-3 receptor (NK3) antagonists. Neurokinin receptors are found in the nervous system and the circulatory system and peripheral tissues of mammals, and therefore are involved in a variety of biological processes. Neurokinin receptor antagonists are consequently expected to be useful in the treatment or prevention of various mammalian disease states, for example pulmonary disorders like asthma, cough, bronchospasm, chronic obstructive pulmonary diseases, and airway hyperreactivity; skin disorders and itch, for example, atopic dermatitis, and cutaneous wheal and flare; neurogenic inflammation inflammatory diseases such as arthritis, migraine, nociception; CNS diseases such as anxiety, Parkinson's disease, movement disorders and psychosis; convulsive disorders, renal disorders, urinary incontinence, ocular inflammation, inflammatory pain, and eating disorders such as food intake inhibition; allergic rhinitis, neurodegenerative disorders, psoriasis, Huntington's disease, depression, and various gastrointestinal disorders such as Crohn's disease. In particular, NK1 receptors have been reported to be involved in microvascuiar leakage and mucus secretion, and NK2 receptors have been associated with smooth muscle contraction, making NK 1 and NK2 receptor antagonists especially useful in the treatment and prevention of asthma. Moreover, NK3 receptor antagonists are especially useful in the treatment and prevention of asthma, inflammatory diseases and conditions, such as ocular inflammation, allergic rhinitis, cutaneous wheal and flare, psoriasis, atopic dermatitis, CNS diseases such as anxiety and Parkinson's disease. Summary of the Invention The invention relates to compounds of the formula: each X is independently, O, (H,H), NRd, or S; n is 0 to 2; u is 0 to 2; I is 0 to 2; m is 1 , and y is 1 to 3; or m is 2, and y is 0; and with the further proviso that no more than one R c is other than H in the moiety; each R c is independently H, Ci-Cβ alkyl, - (CH 2>nr R4 where ni is 1 to 6; Rd is independently selected from the group consisting of H, Ci-Cβ alkyl, CN, OR a , phenyl, substituted phenyl, benzyl, substituted benzyl, or allyl; 0 ? ■ Rb O I H O-C— -R or — N-C-OR a R c ' is H, Ci-Cβ alkyl or (CH2) n OR aι with the proviso that no more than one Rc is other than H; each R a and Rb is independently selected from the group consisting of H, C-i-Cβ alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, O I II allyl; with the proviso that when R4 is — N-C-ORa a , R a is not H; or when R a and Rb are attached to the same nitrogen, then R a and Rb together with the nitrogen to which they are attached, form a 4 to 7 member ring; wherein each Ri and R2 is independently H, C-i-Cβ alkyl, CF3, C 2 F 5 , Cl, Br, I, F, N0 2 , OR a , CN, NR a R b , O Ra Rb O Ra O O O R a II I 1 » I II II II I — O— C-N— R — N-C-OR a ■ N-C-Rb — C-OR a — C — N- Rb 0 O O n s Ra , s Ra , -SR a , and s NHRa ; and where R a is not H o o. n b 0 II I « jn -S— Ra -S— R a — N-C-OR a or when Ri and R2 are on adjacent carbons on a ring, they can form wherein n' is 1 or 2; o II and each R3 is independently H, C1 -Cβ alkyl, CF3, C2F5, c_Ra o O Ra II II I -O— C-Ra — C — N-Rb Cl, Br, I, F, OR a , OCF3, or phenyl; An is heteroaryl or substituted heteroaryl, Q is N or CH; A/2 is heteroaryl or substituted heteroaryl; Z is m mιι n 11 3 3 i »s 0 u--4 r;, Rg proviso that R a is not H; aryl, substituted aryl, heteroaryl, substituted heteroaryl, -NR a Rb. -O-(CR a ,Rb) n 7-aryl, -O- (CR a .Rb) n 7-substituted aryl, -O-(CR a ,Rb) n 7-heteroaryl , -O-(CR a ,Rb) n 7- substituted heteroaryl ,-NRa-(CRa,Rb)r»7-heteroaryl, -NR a -(CR a ,R b )n7- substitut β d heteroaryl, -O-(CR a ,R b )n7-het β rocycloal yl, -O-(CR a ,Rb)n7- subst'rtuted h β terocycloalkyl, -NR a -(CRa,Rb)n7-aryl, -NRa-(CR a ,R b )n7- substituted aryl, -NRa-(CR a ,Rb)nrheterocycloalkyl, -NRa-(CR a ,Rb)nr substituted hθterocycloalkyl; n 7 is 0 to 4; each R θ and Rf is independently selected from the group consisting of H, C-t-Cβ alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, allyl; or Re and Rf taken together with the carbon to which they are attached can also form a carbonyl group with the proviso that no more than one carbonyl group is in the moiety; n 5 is 1 tc 2; each R5 is independently selected from the group consisting of H, OH, 0 II c-Ra f c-i-Cβ alkyl, (CH2)m-R 4 wherein ni is 1 to 6 with the proviso that when n-i is 1, R4 is not OH or NR a R_; also with the proviso that when ns is 2, R5 is C1-C6 alkyl, and two R5 can be attached to the nitrogen to form a quaternary salt; Rβ is H, d-Cβ alkyl, C3-C6 cycloalkyl, wherein X3 is (H,H), O, NR_, or S; or Re is heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, when n3 is 0-4; when Rβ.Rf taken together with the carbon atom to which they are attached form a carbonyl group and n 3 is 1 , Re can also be -ORa wherein Ra is not H, or R e is -NRa.Rb. -O-(CRa,Rb)n7-heteroaryl, -O-(CR a ,Rb)n7-substituted heteroaryl, -O-(CR a ,Rb)r>7-heterocycloalkyl, -O-(CR a ,Rb)n7-substituted heterocycloalkyl, -O-(CR a ,Rb)n7-aryl, -O-(CR a , Rb)n substituted ai I, -NRa-(CRa,Rb)n7-heteroaryl, -NR a -(CRa,Rb)n7-substituted heteroaryl, -NR a -(CRa,Rb)n7-aryl, -NR a -(CRa,Rb)π7-substituted aryl, -NR a -(CR a ,Rb)nr heterocycloalkyl, -NRa-(CR a ,Rb)n7-substituted heterocycloalkyl, wherein R a and R are each independently selected from the group consisting of H and C1-C6 alkyl; or any enantiomer thereof, or a pharmaceutically acceptable salt thereof. All of the variables in the above formulas such as Z, Ri , R2, and R3, have the same meaning throughout the specification unless otherwise specified. Preferred compounds of the invention are compounds of formula I, wherein each X is O or (H,H) and at least one X is O. Also preferred are compounds of formula I wherein both X's are O. Also preferred are compounds of formula I wherein I is 0, m is 1 , and y is 1-3. Also preferred are compounds of formula I wherein n is 1 and u is 0. Also preferred are compounds of formula I wherein Aη is wherein Q is N orCH; each Xi is independently O, S or NR a; each X2 is independently CH or N; and Also preferred are compounds of formula I wherein Ar2 is Also preferred are compounds of formula I wherein Z is Also preferred are compounds of formula I wherein Z is Also preferred are compounds of formula I wherein Z is Also preferred are compounds of formula I wherein Z is wherein Rg is -ORa, -NR a Rb, and -0-(CR a ,Rb) n 7-heteroaryl , with the proviso that when Rg is 0-(CR a ,Rb) n 7-heteroaryl, R a and Rb are each independently selected from the group consisting of H and C-i-Cβ alkyl; n is 0 to 4. Also preferred are compounds of formula I wherein both X's are O; I is 0; m is 1 ; y is 1-3; n is 1 ; u is 0; A is Ar2 is wherein n4 is 0 or 1. Z is defined in Formula I, when Re,Rf are H, Ci -C6 alkyl, allyl , n 3 is 0-4 and Re is cycloalkyl t — Ci-Cδ alkyl or Re and Rf taken together with the carbon to which they are attached form a carbonyl group, n 3 is 1 and Re is -0-(CR a ,Rb)n7- , wherein L is 0- cycloalkyl, cycloalkyl f — <_ c r C 6 alkyl Also preferred are compounds of formula II π where in R c is H; mi is 0 or 1 ; y is 1-3; Arι and Ar2 are both Re is ■cycloalkyl t S— Cι-C 6 alkyl or R e and Rf taken together with the carbon to which they are attached form a carbonyl group, n3 is 1 and Re is -0-(CR a ,Rb)n7-L, wherein L is ■ O- cycloalkyl, ■ C r C 6 alkyl Also preferred are compounds of the invention of the formula II: n wherein Ari and Ar2 are both Also preferred are compounds of the invention of the formula III: m wherein An and Ar2 are both Exemplary compounds of the invention are compounds of the formulas: or any enantiomer thereof, or a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition comprising a thereapeutically effective amount of a compound of formula I in combination with a pharmaceutically acceptable carrier. The invention also relates to a method for inducing neurokinin antagonism which comprises administering a neurokinin antagonistic effective amount of a compound of formula I to a mammal in need thereof. The invention also relates to a method for treating chronic airway diseases such as asthma and allergies; inflammatory diseases such as inflammatory bowel disease, psoriasis, fibrositos, osteoarthritis, and rheumatoid arthritis; migraine; central nervous system disorders such as depression, psychosis, dementia, and Alzheimer's disease; Down's syndrome; neuropathy; multiple sclerosis; ophthalmic disorders; conjunctivitis; auto immune disorders; graft rejection; systemic lupus erythematosus; Gl disorders such as Crohn's disease and ulcerative colitis; disorders of bladder function; circulatory disorders such as angina; Raynaud's disease; coughing and pain. In particular, the invention also relates to a method of treating asthma which comprises administering to a mammal in need of such treatment an anti-asthma effective amount of a compound of formula I for such purpose. Detailed Description of the Invention As used herein the term alkyl means a straight or branched, saturated hydrocarbon chain having from 1 to 6 carbon atoms. The number of carbon atoms may be designated. For example, "C-i-Cβ alkyl" represents a straight or branched, saturated hydrocarbon having from 1 to 6 carbon atoms. The term C3-C6 cycloalkyl means a cycloalkyl having from 3 to 6 carbon atoms, that is cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. The term alkenyl means means a straight or branched, saturated alkenyl having from 2 to 6 carbon atoms. The number of carbon atoms may be designated. For example, "C2-C6 alkenyl" represents a straight or branched alkenyl having from 1 to 6 carbon atoms. The term alkynyl means a straight or branched alkynyl having from 2 to 6 carbon atoms. The number of carbon atoms may be designated. For example, "C2-C6 alkynyl" represents a straight or branched chain alkynyl having from 2 to 6 carbon atoms. As used herein, a heavy dark line ( — ■ ) denotes a chemical bond coming above the plane of the page. A dashed line (••••■ .. ) denotes a chemical bond coming below the plane of the page. As used herein, , for example, means that Ri , R2, and R3 can be in either of the rings of the above naphthyl moiety. Asymmetric centers exist in compounds of formula I of the invention. Accordingly, compounds of formula I include stereoisomers. All such isomeric forms and mixtures thereof are within the scope of the present invention. Unless otherwise indicated, the methods of preparation disclosed herein may result in product distributions which include all possible structural isomers, although it is understood that physiological response may vary according to stereochemical structure. The isomers may be separated by conventional means such as fractional crystallization, preparative plate or column chromatography on silica, alumina, or reversed phase supports or HPLC (high performance liquid chromatography). Enantiomers may be separated, where appropriate, by derivatization or salt formation with an optically pure reagent, followed by separation by one of the aforementioned methods. Alternatively, enantiomers may be separated by chromatography on a chiral support. The compounds of formula I can exist in unsolvated as well as solvated forms, including hydrated forms, e.g. the hemihydrate. In general, the solvated forms, with pharmaceutically acceptable solvents such as water, ethanol, and the like are equivalent to the unsolvated forms for the purposes of the invention. Those compounds of formula I which contain a basic group such as -CH2NH2, form pharmaceutically acceptable salts. The preferred pharmaceutically acceptable salts are nontoxic acid addition salts formed by adding to a suitable compound of the invention about a stoichiometric amount of a mineral acid , such as HCl, HBr, H2SO4 or H3PO4 or of an organic acid such as acetic, propionic, valeric, oleic, palmitic, stearic, lauric, benzoic, lactic, para-toluenesulfonic, methanesulfonic, citric, maleic, fumaric, succinic and the like, respectively. General Methods of Preparation The compounds of this invention may be prepared by one of the following general methods. As used herein RT means room temperature. Unless otherwise indicated, variables in the structural formulas below are as defined above. Starting materials and reagents used in the methods and examples below, are known or may be prepared according to known methods. As used herein the term "substituted phenyl" means wherein Ri , R2, and R3 are as described herein. "substituted " means substituted by Ri , R2, and/or R3 as described herein. "Aryl" means phenyl, naphthyl, indenyl, tetrahydronaphthyl, indanyl, anthracenyl or fluorenyl. "Halogeno" refers to fluoro, chloro, bromo or iodo atoms. "Heterocycloalkyl" refers to 4- to 6-membered rings comprising 1 to 3 heteroatoms independentiy selected from the group consisting of -0-, -S- and -N(R 6 )-, with the remaining ring members being carbon. Examples of heterocycloalkyl rings are tetrahydrofuranyl, pyrrolidinyl, piperidinyl, morpholinyl, thiomorpholinyl and piperazinyl. "Heteroaryl" refers to 5- to 10-membered single or benzofused aromatic rings comprising 1 to 3 heteroatoms independently selected from the group consisting of -0-, -S- and -N=. Examples of single-ring heteroaryl groups are pyridyl, isoxazolyl, oxadiazolyl, furanyl, pyrrolyl, thienyl, imidazolyl, pyrazolyl, tetrazolyl, thiazolyl, thiadiazolyl, pyrazinyl, pyrimidinyl, pyridazinyl and triazolyl. Examples of benzofused heteroaryl groups are quinolinyl, thianaphthenyl and benzofurazanyl. N-oxides of nitrogen- containing heteroaryl groups are also included. All positional isomers are contemplated, e.g., 1 -pyridyl, 2-pyridyl, 3-pyridyl and 4-pyridyl. Where R 2 and R 3 substituents form a ring and additional heteroatoms are present, the rings do not include adjacent oxygen and/or sulfur atoms or three adjacent heteroatoms. Typical rings so formed are morpholinyl, piperazinyl and piperidinyl. As used herein, the term "BOC" means t-butoxycarbonyl. As used herein, the term "Ph" means phenyl. As used herein, the term "RT" means room temperature. As used herein, the term "parallel synthesis" means the preparation of individual chemical compounds as one of a batch of, for instance, 20, 30, or even 100 identical reactions on usually a single substrate but using a different reagent in each vessel. Such reagents are always of the same general class- in this case, either carboxylic acids or organic amines in any set of parallel reactions. The conditions used for each reaction are identical to those described in the examples , except that a simplified work-up is employed, generally a simple wash either with acid or base if appropriate, then water. The presence of the product is detected by thin layer chromatography (TLC) using known products as representative standards. Further characterization by combination HPLC/MS is generally performed. No further purification is performed on these materials before they are submitted to biological assays. As used herein, each R c and Rc' is independently selected from the group consisting of H, Ci -Cβ alkyl, C2-C6 alkenyl, C2-C6 alkynyl, unsubstituted or substituted phenyl, and unsubstituted or substituted benzyl, The starting materials in the methods below are either known or can be prepared in accordance with known methods. In particular, the following compounds are either known or can be prepared in accordance with known methods: the diamine A, the compounds of formulas A, VI, vm, X, XI, XIV, xvm, XIX, XXa, A', XXV, and Z-H, as well as esters of formula XI, and compounds of formula 2 υ+1 " ^ . Method 1. If the group Ar 2 is an aromatic group with no I or Br substituents, then the following method may be used to prepare the useful intermediates (IV): Transition metal catalyzed coupling of 2-chloropyrazine with an aromatic Grignard reagent in a dry, ether solvent, such as THF, yields the aryl-substituted pyrazine of formula II'. The catalyst shown, [1 ,2- bis-(diphenylphosphino)ethane]nickel" chloride, is a preferred reagent for this transformation. Where Ar 2 has no halo substituents, reduction of a compound of formula II' by catalytic hydrogenation, using, for instance, palladium acetate, preferably in acetic acid solvent, results in preferential reduction of the pyrazine ring, leaving the aromatic ring unreduced, that is, it results in a compound of formula II. Similarly, 10% Pd on charcoal (Pd-C) can be used in an alcohol solvent, preferably methanol, with or without the addition of a small quantity (1 to 5 equivalents) of acetic acid. Reaction times of about 1 to 24 hours generally suffice for this reaction, which is preferentially run at room temperature or slightly above (up to about 50°C) and using from 1 to about 6 atmospheres pressure of hydrogen. The intermediate of formula II may also be prepared from a compound of formula II', even if the group Ar2 contains halogen atoms, by reduction using a strong hydride ion donor, preferably lithium aluminum hydride (LAH) or diisobutyl aluminum hydride (DIBAL-H) in an ether solvent, such as ether, THF or dimethoxyethane (DME). Selective alkylation of a compound of formula II is possible using low temperature conditions. Thus, reacting a compound of formula II with a substituted aryl-alkyl halide of formula III where I is 0 to 2, results in the formation of the 4-substituted derivative of formula IV. Suitable conditions include use of a halogenated solvent, such as CH2CI2, at low temperature. Suitable temperatures are from -78°C initially, allowing the reaction mixture to warm gradually to RT if the reaction is not completed after several hours. The reaction is catalyzed by the addition of an equivalent amount of an organic base, such as triethylamine and diisopropylethylamine (Hϋnig's base). Method 2. If the group At ∑ contains one or more halogen atoms on an aromatic ring and the other groups are as in Method 1 , then an alternate route to a compound of formula IV is preferred. In addition, this method can be used to prepare compounds in which I is from 0 to 2. Mono-protection of the diamine of formula (A), preferably with BOC anhydride, or other agents known to introduce the t-butyloxycarbonyl protecting group, in an alcohol solvent, such as methanol, preferably at about -10°C, produces a compound of formula V. (A) (V) These compounds are used to perform a reductive amination reaction with the aldehyde of formula VI to produce an amine of formula VII. (In structures (A), (V), (VII), and (IX) herein, R c can be bound to any position between the two nitrogens. In cyclic structures like (IVA) below, R c can be bound to any available cyclic position that is occupied by carbon, and that is between the two nitrogens.) Suitable conditions for this type of reaction include the use of an alcohol solvent, preferably methanol, or 2,2,2-trifluoroethanol, made slightly acidic with a weak organic acid, such as acetic acid, and a reducing agent known to favor reductive amination reactions, preferably sodium cyanoborohydride, NaBHsCN. (VII) Reaction of a compound of formula VII with an α-haloketone of formula VIII, in which Ar2 preferably represents a halogenated aromatic ring, but may be any of the claimed aromatic rings, in the presence of an organic base, such as di-isopropylethylamine, also known as Hϋnig's Base, in an ether solvent, such as THF, results in the formation of the intermediates of formula IX. Removal of the BOC protecting group using a suitable acidic catalyst, such as trifluoroacetic acid, followed by an intramolecular reductive amination, under conditions such as those described above for the preparation of a compound of formula VII, leads to the formation of compounds of formula IVA. (IX) (IVA) Method 3. An alternate route to compounds of the invention in which I is 0 to 2 is as follows. Standard coupling of an N-protected amino acid of formula X, wherein Ar 2 is as described above, with an amino acid ester derivative (R' is C2-C4 alkyl, preferably, the ethyl ester of formula XI, .Et in the formulas herein means ethyl), produces a dipeptide of formula XII. A suitable protecting group is BOC, although many others may also be used. Other esters of the amino acid may also be used. Standard coupling techniques may be applied, an example being the use of N-hydroxybenztriazole (HOBT) and a water-soluble carbodiimide, such as 1- (3-dimethylaminopropyl)-3-ethylcarbodiimide (DEC), in a non-hydroxylic solvent such as CH2CI2, DMF or a mixture of the two foregoing solvents. The reaction is run, preferably, at or below RT, and takes from 1 to 40 hours for completion, depending upon the substrates. Removal of the protecting group under standard conditions, followed by treatment of the product with a base results in cyclization to the diketopiperazine of formula XIII. Suitable conditions for removal of the exemplified BOC group are well known in the art and include catalysis by trifluoroacetic acid (TFA). A suitable base for cyclization is the alkali metal salt of an alcohol in the alcohol itself used as solvent. For example, a solution of sodium ethoxide in ethanol may be used. The temperature is preferably around RT but may be slightly above or below, in the range 0°C to about 40°C. The reaction is generally complete within a few hours. Suitable reaction times are from 1 to 24 hours. Reduction of the diketopiperazine of formula XIII to a compound of formula II may be accomplished preferentially with a strong hydride reducing agent, such as LAH or a solution of sodium bis(2-methoxy- ethoxy)aluminum hydride in toluene (also known as Red-AI®), or the BH3.S(CH3)2 complex. Suitable solvents for this reaction are DME and other higher boiling ethers since the reaction is run at elevated temperatures, from about 50°C to about 110°C, preferably at about 90°C. Alternatively, a compound of formula of II may be prepared by the scheme shown below ( J. Med. Chem., £, 191 (1966)). As used herein L is any readily available ester residue such as C1-C7 alkyl, more preferably methyl or ethyl. X • Cl, Br, I H 2 N NH 2 G A compound of formula II may be converted to a compound of formula IV by the processes described in Method 1 above or Method 6 below. Method 4. The intermediates of formula IV or IVA, formed via any of the previous methods, may be further processed as follows. A compound of formula IVA will be used in the Schemes. Reaction of a compound of formula IVA with an activated halo-acid, generally the acid halide of formula XIV, in which Hal represents Cl, Br, or I, yields the acylated derivative of formula XV that is, m is 1 for formula I. An organic base is used to take up the hydrogen halide formed in the reaction, suitable bases being triethylamine (TEA) and Hϋnig's Base. Suitable reaction media include halogenated solvents, such as methylene chloride and chloroform. The reaction is preferably run at low temperature, at least initially. Suitable temperatures are in the region of -50°C down to -80°C. Later in the reaction it may be desirable to allow the mixture to warm up to about RT to ensure completion of the reaction. Reaction of the halogenated amides of formula XV with an amine of formula Z-H results in formation of the products of formula XVI, which are compounds of the invention in which X is O and m is 1. Compounds of formula XVI have been modified to show the fact that these products could have been prepared from compounds of formula IVA as well as from IV. Suitable solvents for this reaction are halogenated hydrocarbons, such as methylene chloride, and an organic base is present to absorb the H-Hal formed. Appropriate bases include Hϋnig's Base. The reaction is performed at or around RT, a suitable temperature being generally in the range of from 0°C to 40°C. Reaction is complete within 1 to 48 hours. Method 5. Compounds of formula XVI where y ≠ 0 may be converted to other compounds of the invention of formula XVII by reduction under controlled conditions. Suitable reducing agents to effect this transformation include the borane-dimethyl sulfide complex, as well as other less selective reagents, such as LAH, (assuming that no other group reactive to LAH is present), Red-AI®, and diborane in ether. Effective temperatures for the borane- dimethylsulfide complex to reduce compounds of formula XVI, range from RT to the reflux temperature of the solution of the reagent in THF (about 80°C). Method 6. Intermediates of the formula XVIII may be selectively acylated by coupling with an acid of the formula XIX. Standard coupling techniques may be applied, an example being the use of HOBT, a water-soluble carbodiimide, such as DEC, and an organic base, such as triethylamine, in a non-hydroxylic solvent, such as CH2CI2, at a temperature of about -20°C initially. The mixture may be allowed to warm to RT to complete the reaction. The product of reaction is the amide of formula XX. (XVIII) Compounds of the formula XX, may be further acylated using an acid halide of formula XIV. The reaction is run, preferably at about -78°C, over a period of 1 to 12 hours, in a halogenated solvent, such as methylene chloride or similar solvent. An organic tertiary amine is used to absorb the H-Hal produced in the reaction. Suitable amines include triethylamine and Hϋnig's Base. As used herein Hal means Cl, Br, or I. (XXI) The compounds of formula XXI , that is, m is 1 in formula I, y = 1-3, 1 = 0-2 may be used for further reaction without isolation. Additional organic base, for instance, Hϋnig's Base, is added to the mixture followed by Z-H, at or around -78°C. The reaction is completed by allowing the mixture to warm to RT overnight yielding the compounds of formula XXII rd methods. The compounds of formula XXII, in which y = 1-3 may be converted to other products of formula XXIII by reduction under controlled conditions. Suitable reducing agents to effect this transformation include the borane-methyl sulfide complex, as well as other less selective reagents, such as LAH, Red-AI®, and diborane in ether or other unreactive solvents, such as THF. Using the borane-methyl sulfide complex in THF, at the reflux temperature of the solution, which is about 80°C, the reaction is complete in about 2 hours to 48 hours depending on the precise substrate. Some of the substrates Z-H for the alkylation reaction were synthesized from diamino compound (A) by initial conversion to the t-BOC protected derivative(B) followed by removal of the benzyl group by hydrogenolysis over a suitable catalyst such as Pd(OH)2 to yield the t-BOC protected derivative (C). Subsequent elaboration of (C) can be accomplished by either alkylation or reductive alkylation depending on the availability of reagents for these reactions. Reaction of the intermediate (C) with an aldehyde or ketone (D) under the conditions of reductive amination, such as in methanol and in the presence of NaBHsCN with sufficient AcOH (acetic acid) present to allow the reaction to proceed at a suitable rate, produces the amine (E) from which the t-BOC group may be removed with 4N-HCI in dioxane followed by basification, for instance, with an aqueous solution of NaOH, to produce the compound of formula (F). The same product, (Ea), may be prepared from (C) by alkylation with the halide derivative (G) in which "Hal" is Cl, Br, or I. Other activated leaving groups are also possible for this reagent , such as mesylates or tosylates. The reagent is preferably primary but the reaction can also often be made to work acceptably for secondary derivatives. The product of the alkylation, (Ea), may be treated as described above to produce the reagent (Fa) which represents one of the preferred forms of Z which can be used to convert a compound of formula XXI to a compound of formula XXII. The intermediate (C) (below) may also be modified by acylation, for instance with an acid halide of formula (H), to produce the intermediate (I), in which n 3 ≠ 0. Removal of the BOC protecting group, as described previously, leads to the amine (J) which represents one of the preferred forms of Z. This may be used to convert a compound of formula (XXI) to a compound of the invention, as described above. Method 6a A useful intermediate for certain variations in the group Z is the compound (K). This may be prepared from (XXI) and the protected amine (L). The starting material for this process is the N-BOC protected amine (M) which may be converted to (L) by standard techniques involving formation of the oxime using hydroxylamine hydrochloride in pyridine followed by reduction with hydrogen over Raney nickel in ethanol solution. Removal of the protecting group from (K), under conditions described previously, results in the amine (N). (N) - -Use of this intermediate under conditions of acylation, under controlled conditions, results in reaction at the ring nitrogen atom to yield products such as (O). Either the acid halide , e.g. chloride (P), may be used, or a coupling reaction with a carboxylic acid may be used under conditions essentially similar to those described earlier using a water- soluble carbodimide reagent, for instance. Sometimes the starting material (N) is provided as a salt, such as the HCl salt. In this case, it is necessary to add an organic tertiary base, such as Hϋnig's base to produce the free amine. Alkylation of (N) may be accomplished with a suitable halogen- containing reagent, for instance, to produce (Q). Reagents such as (G) may be used for this conversion. In some cases, one of the -C(Re)(Rf)- groups may be a carbonyl group with the exception that the carbon in the carbonyl can not be directly attached to the nitrogen atom since these products are amides which are described above. Under certain circumstances, specifically where at least one of the groups Re and Rf on the carbon atom to be directly attached to the ring nitrogen is H, then a reductive alkylation reaction may be performed, as described previously, to produce the compound of the invention (R). The reagent used for this conversion is (D), an aldehyde (if Re = H) or ketone. where n 3 = 1-4 Method 7. The acylated derivatives of formula XX from Method 6 may be reduced to the saturated alkyl chain derivatives of formula IVA. (XX) (IVA) The process to conduct this conversion is the same as described in Method 6 for conversion of a compound of formula XXII to a compound of formula XXIII. The reagent of preference is the borane- methyl sulfide complex. A compound of formula IVA can be converted to a target compound of formula XVI as described previously. An alternate route to compounds of structure (XXπ) also starts with compound (XVHI). Initial reaction with an amine protecting group reagent, preferably BOC anhydride, produces the N-t-butyloxycarbonyl derivative of the formula XXVIII. As before, reaction occurs preferentially at the nitrogen atom further away from the Ai"2 group. Reaction of this intermediate with a reagent of structure (XTV) as described above, leads to the halo-derivative (XXIX). Reaction of (XXIX) with Z-H, again as described above, produces the intermediate (XXX) which may be de-protected to produce (XXXI). Suitable reagents include trifluoroacetic acid and HCl. Reaction of (XXXI) with a carboxylic acid (XIX) under such coupling conditions as described above, leads to the products of formula (XXII). Method 7a. Synthesis of the compounds of the invention wherein the pendant aromatic group Ar2, or the pendant aromatic group Ar and its sidechain, are located in the alternate ring position to the compounds of formula XXII (i.e. compounds of formula C below), may be prepared using compounds of formula XXVIII from method 7 as starting materials. Coupling of Rc compounds of formula XXVIII with any of the acids 1 2 under standard coupling conditions, for instance using HOBT, EtβN and DEC in CH2CI2, produces the intermediate (A). Removal of the t-BOC or other protecting group under standard conditions releases the free amine (B). Acylation of (B) and further reaction with Z-H proceeds as described in Method 6 for the conversion of (XX) via (XXI) to (XXII) to produce compound (C) of the invention. Method 8. A method for introducing a group, R c , into the sidechain of a compound of the invention begins with a previously prepared compound of formula (XX). This may be coupled with a suitably protected amino-acid derivative of formula (XXXII) in which the t-BOC group is used as a representative protecting group. Use of a relatively reactive coupling agent, such as BOP-CI of formula (XXXIII), is preferred and the reaction is run under standard coupling conditions well known to one skilled in the art. Suitable conditions include the use of CH2CI2 and/or DMF as solvent, with triethylamine or Hϋnig's Base, and a temperature between 0°C initially and RT. Usual work-up conditions yield the protected intermediate of formula (XXXIV). In the case of (XXXIV), in which the N-protecting group is t- BOC, the usual conditions for removal of such a group may be used to free the amine function. Various concentrations of CF3CO2H in CH2CI2 will usually suffice. In some substrates a fairly dilute solution (e.g. 2N) will be sufficient whereas in other cases a more concentrated solution, up to neat TFA, may be necessary. In addition, other N-protecting groups may be employed and removed by methods well known in the art. An example is use of the N-Cbz which may be removed under either acidic or hydrogenolytic conditions. The result of deprotection is the amine intermediate of the formula (XXXV). XXXII, XXXIII Conversion of intermediate of the formula (XXXV) to compounds of the invention is then carried out by a reductive alkylation process. The group Z is introduced into the molecule using an aldehyde or ketone in which the aforementioned group is present at the carbon atom that is to be joined to the amino group of the formula (XXXV). An example of such an intermediate is a compound of the formula (XXXVI). xxxvi After the reaction this group becomes the Z group of the compounds of the invention, that is, the "Y-NH" group shown in compounds of the formula (XXXVII) just below XXXVII is equivalent to the "Z" group shown in the Summary of the Invention. Conditions for this reductive amination procedure are known in the art and are exemplified by the use of NaBH3CN in MeOH with the addition of several equivalents of acetic acid. Generally, the reaction is performed at RT and is left to react overnight. Product is isolated by standard means, such as decomposition of excess reagent with H2O and extraction of the product into an organic solvent such as CH2CI2 or a mixture of Et2θ and CH2CI2. Using procedures similar to those described in the above or using procedures known to those skilled in the art, one can produce all of the compounds of formula I of the invention. For example, one can obtain compounds of the invention of formula I wherein the R c moiety is on various carbons of the piperazine ring. The in vitro and in vivo activity of the compounds of formula I can be determined by the following procedures. In vitro procedure to Identify NK j activity Test compounds are evaluated for their ability to inhibit the activity of the NKι agonist Substance P on the isolated guinea pig vas deferens. Freshly cut vas deferens are removed from male Hartley guinea pigs (230-350g) and suspended in 25 ml tissue baths containing Kreb's Henseleit solution warmed to 37°C and constantly aerated with 95% O2 and 5% C02- Tissues are adjusted to 0.5 g and allowed to equilibrate for a period of 30 minutes. The vas deferens are exposed to an electrical field stimulation (Grass S48 Stimulator) every 60 seconds at an intensity that will cause the tissue to contract 80% of its maximum capacity. All responses are recorded isometrically by means of a Grass force displacement transducer (FT03) and Harvard electronic recorder. Substance P inhibits the electrical field stimulated-induced contractions of the guinea pig vas deferens. In unpaired studies, all tissues (control or drug treated) are exposed to cumulative concentrations of Substance P (1 X10 -10 M - 7X10' 7 M). Single log-concentrations of the test compounds are given to separate tissues and allowed to equilibrate for 30 minutes before a Substance P concentration-response curve is generated. At least 5 separate tissues are used for each control and individual drug-concentration for every drug assay. Inhibition of the Substance P is demonstrated by a right ward shift of its concentration-response curve. These shifts are used to determine the pA2 value, which is defined as the negative log of the molar concentration of the inhibitor which would require that twice as much agonist be used to elicit a chosen response. This value is used to determine relative antagonist potency. Isolated Hamster Trachea NKg Assay General methodology and characterization of hamster trachea responses to neurokinin agonists as providing an Nfø monoreceptor assay is found in CA. Maggi, et al., Eur. J. Pharmacol. 166 (1989) 435 and J.L Ellis, et al., J. Pharm. Exp. Ther.267 (1993) 95. Continuous isometric tension monitoring is achieved with Grass FT-03 force displacement transducers connected to Buxco Electronics preamplifiers built into a Graphtec Linearcorder Model WR 3310. Male Charles River LAK VG (SYR) hamsters, 100-200 g fed weight, are stunned by a sharp blow to the head, loss of corneal reflex is assured, the hamsters are sacrificed by thoractomy and cutting the heart. Cervical trachea segments are removed to room temperature Krebs buffer, pH 7.4, aerated with 95% O2 - 5% CO2 gas and cleaned of adhering tissue. The segments are cut into two 3-4 mm long ring segments. Tracheal rings are suspended from transducers and anchored in 15.0 ml water jacketed organ baths by means of stainless steel hooks and 6-0 silk. Baths are filled with Krebs buffer, pH 7.4, maintained at 37°C and continuously aerated with 95% O2 - 5% CO2 gas. Tracheal rings are placed under 1.0 g initial tension and allowed a 90 min equilibration period with four 1 μM NKA challenge, wash and recovery cycles at 20 min intervals. 30 min vehicle pretreatment is followed by cumulative additions of rising doses of NKA (3 nM - 1 μM final concentration, 5 min intervals between additions). The final NKA response is followed by a 15 min wash and recovery period. 30 min pretreatment with a test compound or its vehicle is followed by cumulative additions of rising doses of NKA (3 nM - 10 μM final concentration if necessary, 5 minutes intervals between additions). The final NKA response is followed by a 1 mM carbachol challenge to obtain a maximal tension response in each tissue. Tissue responses to NKA are recorded as positive pen displacements over baseline and converted to grams tension by comparison to standard weights. Responses are normalized as a % of the maximal tissue tension. EDso's are calculated for NKA from the control and treated NKA dose responses and compared. Test compounds resulting in an agonist dose ratio > 2 at a screening concentration of 1 μM (i.e. pA2≥ = 6.0) are considered actives. Further dose response data is obtained for actives so that an apparent pA2 estimate can be calculated. pA2 is calculated either by estimation of Kj as described by Furchgott (where pA2 = - Log Kj, R.F. Furchgott, Pharm. Rev. 7 [1995] 183) or by Shild Plot Analysis (O. Arunlakshana & H.O. Shild, Br. J. Pharmacol. 14[1959] 48) if the data is sufficient. Effect of NK j Antaαonists on Substance P-lnduced Airway Microvascular Leakage in Guinea Pigs Studies are performed on male Hartley guinea pigs ranging in weight from 400-650 g. The animals are given food and water ad libitum. The animals are anesthetized by intraperitoneal injection of dialurethane (containing 0.1 g/ml diallylbarbituric acid, 0.4 g/ml ethylurea and 0.4 g/ml urethane). The trachea is cannulated just below the larynx and the animals are ventilated (VT = 4 ml, f = 45 breaths/min) with a Harvard rodent respirator. The jugular vein is cannulated for the injection of drugs. The Evans blue dye technique (Danko, G. et al., Pharmacol. Commun.. 1 , 203-209, 1992) is used to measure airway microvascular leakage (AML). Evans blue (30 mg/kg) is injected intravenously, followed 1 min later by i.v. injection of substance P (10 μg/kg). Five min later, the thorax is opended and a blunt-ended 13-guage needle passed into the aorta. An incision is made in the right atrium and blood is expelled by flushing 100 ml of saline through the aortic catheter. The lungs and trachea are removed en-bloc and the trachea and bronchi are then blotted dry with filter paper and weighed. Evans blue is extracted by incubation of the tissue at 37°C for 18 hr in 2 ml of formamide in stoppered tubes. The absorbance of the formamide extracts of dye is measured at 620 nm. The amount of dye is calculated by interpolation from a standard curve of Evans blue in the range 0.5-10 μg/ml in formamide. The dye concentration is expressed as ng dye per mg tissue wet weight. Test compounds were suspended in cyclodextran vehicle and given i.v. 5 min before substance P. Measurement pf wz Activity in Vivo Male Hartley guinea pigs (400-500 gm) with ad lib. access to food and water are anesthetized with an intraperitoneal injection of 0.9 ml/kg diaiurethane (containing 0.1 g/m diallylbarbituric acid, 0.4 g/ml ethylurea and 0.4 g/ml urethane). After induction of a surgical plane of anesthesia, tracheal, esophageal and jugular venous cannulae are implanted to facilitate mechanical respiration, measurement of esophageal pressure and administration of drugs, respectively. The guinea pigs are placed inside a whole body plethysmograph and the catheters connected to outlet ports in the plethysmograph wall. Airflow is measured using a differential pressure transducer (Validyne, Northridge CA, model MP45-1 , range ± 2 cmH2θ) which measures the pressure across a wire mesh screen that covers a 1 inch hole in the wall of the plethysmograph. The airflow signal is electrically integrated to a signal proportional to volume. Transpulmonary pressure is measured as the pressure difference between the trachea and the esophagus using a differential pressure transducer (Validyne, Northridge, CA, model MP45-1 , range ± 20 cm H2O). The volume, airflow and transpulmonary pressure signals are monitored by means of a pulmonary analysis computer (Buxco Electronics, Sharon, CT, model 6) and used for the derivation of pulmonary resistance (R|_) and dynamic lung compliance (CDyn)- Bronchoconstriction Due to NKA Increasing iv doses of NKA are administered at half log (0.01 -3 μg/kg) intervals allowing recovery to baseline pulmonary mechanics between each dose. Peak bronchoconstriction occurs within 30 seconds after each dose of agonist. The dose response is stopped when Coyn is reduced 80-90% from baseline. One dose-response to NKA is performed in each animal. Test compounds are suspended in cyclodextran vehicle and given i.v. 5 min before the initiation of the NKA dose response. For each animal, dose response curves to NKA are constructed by plotting the percent increase in R|_ or decrease in Coyn against log dose of agonist. The doses of NKA that increased RL by 100% (Rl_100) or decreased Coyn by 40% (Coyn40) from baseline values are obtained by log-linear interpolation of the dose response curves. Neurokinin Receptor Binding Assavfcϊ Chinese Hamster ovary (CHO) cells transfected with the coding regions for the human neurokinin 1 (NKi ) of the human neurokinin 2 (NK2) receptors are grown in Dulbecco's minimal essential medium supplemented with 10% fetal calf serum, 0.1 mM non-essential amino acids, 2 mM glutamine, 100units/ml of penicillin and streptomycin, and 0.8 mg of G418/ml at 37°C in a humidified atmosphere containing 5% CO2. Cells are detached from T-175 flasks with a sterile solution containing 5mM EDTA in phosphate buffered saline. Cells are harvested by centrifugation and washed in RPMI media at 40°C for 5 minutes. The pellet is resuspended inTris-HCI (pH7.4) containing 1 uM phosphoramidon and 4 ug/ml of chymostatin at a cell density of 30 x 10 6 cells/ml. The suspension is then homogenized in a Brinkman Polytron (setting 5) for 30-45 seconds. The homogenate is centrifuged at 800 x g for 5 min at 4°C to collect unbroken cells and nuclei. The supernatant is centrifuged in a Sorvall RC5C at 19,000 rpm (44,00 x g) for 30 min at 4°C. The pellet is resuspended, an aliquot is removed for a protein determination (BCA) and washed again. The resulting pellet is stored at -80°C. To assay receptor binding, 50 μl of [ 3 H]-Substance P (9-Sar, 11 -Met [02]) (specific activity 41 Ci/mmol) (Dupont-NEN) (0.8 nM for the NK- 1 assay) or pHj-Neurokinin A (specific activity 114 Ci/ mmole) (Zenca) (1.0 nM for the NK-2 assay) is added to tubes containing buffer (50 mM Tris-HCI (pH 7.4) with 1 mM MnCtø and 0.2% Bovine Serum Albumin) and either DMSO or test compound. Binding is initiated by the addition of 100μl of membrane (10-20 μg) containing the human NK-1 or NK-2 receptor in a final volume of 200 μl. After 40 minutes at room temperature, the reaction is stopped by rapid filtration onto Whatman GF/C filters which have been presoaked in 0.3% polyethylenimine. Filters are washed 2 times with 3 ml of 50 mM Tris-HCI (pH7.4). Filters are added to 6 mis of Ready-Safe liquid scintillation cocktail and quantified by liquid scintillation spectrometry in a LKB 1219 RackBeta counter. Non-specific binding is determined by the addition of either 1 μM of CP-99994 (NKi) or 1μM SR-48968 (NK 2 ) (both synthesized by the chemistry department of Schering-Plough Research Institute). IC50 values are determined from competition binding curves and Ki values are determined according to Cheng and Prusoff using the experimentally determined value of 0.8 nM for the NKi receptor and 2.4 nM for the NK2 receptor. For all of the compounds of the invention, the NKi binding is in a range of about 0-100 % inhibition at 1 μM concentration. For all of the compounds of the invention, the NK2 binding is in a range of about 0-100 % inhibition at 1 μM concentration. It should be understood that while the NK binding for certain compounds of the invention is as low as 0% at 1 μM concentration, that at higher concentrations these compounds are expected to have NK binding inhibition activity. The K| of a compound is that concentration at which the compound caused 50% inhibition of either NKi or NK2. For those compounds of the invention having higher than 50% inhibition of NKi , Kj 's for NKi were determined. The Kj 's for NKi for such compounds fell within a range of about 0.1 nM to about 1 μM. For those compounds of the invention having higher than 50% inhibition of NK2 , Kj 's for NK2 were determined. The Kj 's for NK2 for such compounds fell within a range of about 0.1 nM to about 1 μM. Compounds of formula I exhibit NKi and NK2 antagonist activity to varying degrees, i.e., certain compounds have strong NKi antagonist activity, but weaker NK2 antagonist activity. Others are strong NK2 antagonists, but weaker NKi antagonists. Certain compounds have both strong NKi and NK2 antagonist activities. Some compounds can also be NK3 antagonists. Many compounds of formula I have an asymmetric center and therefore exist as a pair of enantiomers. In such cases, one enantiomer can have different biological activity than the other. For example, one enantiomer can have strong NKi activity and weak NK2 activity while the other enantiomer has weak NKi activity and strong NK2 activity. Certain compounds of formula I have been found to be antagonists of both NKi and NK2 receptors, and are therefore useful in treating conditions caused or aggravated by the activity of NKi and NK2 receptors. The present invention also relates to a pharmaceutical composition comprising a compound of formula I and a pharmaceutically acceptable carrier. Compounds of this invention can be administered in conventional oral dosage forms such as capsules, tablets, powders, cachets, suspensions or solutions, or in injectable dosage forms such as solutions, suspensions, or powders for reconstitution. The pharmaceutical compositions can be prepared with conventional excipients and additives, using well known formulation techniques. Pharmaceutically acceptable excipients and additives include nontoxic and chemically compatible fillers, binders, disintegrants, buffers, preservatives, anti-oxidants, lubricants, flavorings, thickeners, coloring agents, emulsifiers and the like. The daily dose of a compound of formula I for treating asthma, cough, bronchospasm, inflammatory disease, migraine, nociception and gastrointestinal disorders is about 0.1 mg to about 20 mg/kg of body weight per day, preferably about 0.5 to about 15 mg/kg, more preferably 0.5 to about 5 mg/kg. For an average body weight of 70 kg, the dosage range is therefore from about 1 to about 1500 mg of drug per day, preferably about 50 to about 100 mg , given in a single dose or 2-4 divided doses. The exact dose , however is determined by the attending clinician , and is dependent on the potency of the compound administered, the age, weight, condition and response of the patient. The invention disclosed herein is examplified by the following examples, which should not be construed to limit the scope of the disclosure. Alternative mechanistic pathways and analogous structures within the scope of the invention will be apparent to those skilled in the art. EXAMPLE 1 Preparation of 2-(3,4-dichlorophenyl)piperazine A. Synthesis of racemic compound 2-(3,4-Dichlorophenyl)piperazine was synthesized according to the method published in J.Med.Chem. £.191,1966. A. General method for the synthesis of 2-aryl-piperazine derivatives. R 1 « Cl, H or other substituents i.e. OCH 3ι CF3, Br, I, F, etc. R2 = ci, H or other substituents i.e. OCH 3> CF3, Br, I, F, etc. B. Resolution of 2-(3,4-dichlorophenyl)piperazine Step l A solution of 2-(3,4-dichlorophenyl)piperazine (36.05 g, 0.156 mol) in methanol (200 mL) was treated with a solution containing two equivalents of N-acetyl-L-leucine (54.02 g, 0.312 mol) and heated until all of the material was dissolved. EtOAc (2.2 L) was added to this solution and allowed to stand at ambient temperature overnight. The solvent phase was decanted from the precipitated salt and concentrated in vacuo. This procedure was repeated using 37.88 g of 2-(3,4-dichlorophenyl)piperazine (0.164 mol) and 56.68 g of N-acetyl-L-leucine (0.327 mol). Step 2 The concentrated salts from both solvent phases in step 1 were combined and heated in methanol (550 mL) until all of the material dissolved. EtOAc (2.75 L) was added to this solution and allowed to stand at ambient temperature overnight. The solvent phase was decanted from the precipitated salt and concentrated in vacuo to give -95 g of piperazine salt (72% ee of enantiomer A). Step 3 The salt from the solvent phase in step 2 was dissolved in a solution of H2O (800 mL) and aq. ammonia (400 mL) and extracted with CH2CI2 (4 x 400 mL). The combined organic layers were dried with MgSθ4 and concentrated to give 37 g of the piperazine free base. The free base was recrystallized three times from hexane (890, 600 and 450 mL) to give 16 g of piperazine (>99.9% ee of enantiomer A). 24.7°C [α] =-45.0°(MeOH) Step 4 The precipitated salts from step 1 were combined and heated in methanol (220 mL) until all of the material dissolved. EtOAc (2.2 L) was added to this solution and allowed to stand at ambient temperature overnight. The solvent phase was decanted from the precipitated salt and dried in vacuo to give -43 g of piperazine salt (93% ee of enantiomer B). Step 5 A 12.3 g portion of salt (75% ee of enantiomer B) prepared by an analogous procedure to that in step 4 was dissolved in 0.5 M NaOH (400 mL) and extracted with CH2CI2 (4 x 155 mL). The combined organic layers were dried with MgSθ4 and concentrated to give 3.72 g of the piperazine free base. The free base was recrystallized twice from hexane (90 and 70 mL) to give 2.1 g of piperazine (98% ee of enantiomer B). C. Analytical procedure for measuring piperazine enantiomeric purity. The enantiomeric purity of the piperazine was measured by chiral HPLC analysis of the di-tert-butoxycarbonyl piperazine derivative. The di-tert-butoxycarbonyl derivative was prepared by adding a small piperazine sample (free base or salt)(~ .2 mg) to di-tert-butyl dicarbonate (~ 1 mg) and methanol (0.5 mL) and heating at 80°C for 1 h. If the piperazine sample is a salt, triethylamine (20 μL) is also added. The derivative was analyzed by HPLC using a ChiralPak AD column eluting with 95:5 hexane- isopropyl alcohol. EXAMPLE 2 Preparation of (+,-)-[3,5-dimethylbenzoyl]-3-(3,4-dichlorophenyl)piperazine To a cooled solution of CH2CI2 (600 mL) containing 2-(3,4- dichlorophenyl)piperazine (6.934 g, 30 mmol), 3,5-dimethylbenzoic acid (4.55 g, 30 mmol), and N-hydroxybenzotriazole monohydrate (4.05 g, 30 mmol) at -20 °C were added Et3N (4.2 mL, 30 mmol) and N,N- dimethylaminopropylethylcarbodimide (DEC) ( 5.86 g, 30 mmol) under nitrogen. The reaction was kept at -20 °C for an hour and gradually warmed to RT overnight. After stirring 22 hours, the reaction was complete and CH2CI2 (200 mL) was added. The organic solution was washed with brine (150 mL, 3x), dried over MgSθ4, filtered and concentrated under vacuum to give 8.2 g of crude product. The product was crystallized from CH2Cl2/Hexane to give a light yellow solid (6.3 g, 17.34 mmol, 57.8%), m.p.139-141 °C; FAB MS [M+1J+ 35d 363.1. EXAMPLE 3 Preparation of (+,-)-bromoacetyl-2-(3,4-dichlorophenyl)-4-(3,5-dimethyibenzoyl)piperazine To a cooled solution of (+,-)-[3,5-dimethylbenzoyl]-3-(3,4- dichlorophenyl)piperazine (11.5 g, 31.65 mmol) in CH2CI2 (200 mL) at 0 °C was added Hϋnig's base (4.5 g, 35 mmol) and bromoacetyl bromide (6.4 g, 31.65 mmol). The solution was stirred at 0 °C overnight under N2. After completion the reaction was diluted with CH2CI2 (400 mL) and washed with brine (300 mL, 2x), dried over MgSθ4, filtered and concentrated. The crude material was purified by flash grade silica gel chromatography, eluting with 2% [NH4θH/MeOH (1 :9)] / 98% CH2CI2 to give the title compound as a light yellow solid (7.1 g, 47.3%), m.p. 77-79 °C, FAB MS [M+1]+ 35CI,79B Γ 482.9, 484.9. EXAMPLE 4 Preparation of (+)-[3,5-dimethylbenzoyl]-3-(3,4-dichlorophenyl)piperazine (Enantiomer B) The title compound was prepared by an analogous method to that desecribed in Example 2 using (-)2-(3,4-dichlorophenyl)piperazine in place of (+,-)- 2-(3,4-dichlorophenyl)piperazine, m.p. 97-100 °C; FAB MS [M+1]+ 35QI 363.1 ; 22.51 M _ = +87.2°(MeOH). EXAMPLE 5 Preparation of (-)-bromoacetyl-2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)piperazine (Enantiomer B) The title compound was prepared by an analogous method to that desecribed in Example 3 using (+)-[3,5-dimethylbenzoyl]-3-(3,4-dichloro- phenyl)piperazine (Enantiomer B) (Example 4) in place of (+,-)-[3,5- dimethylbenzoyl]-3-(3,4-dichlorophenyl)piperazine, m.p. 68-71 °C, FAB MS , , 21.9°C * _■ -i rs M rs = -45.6°( eOH). [M+1]+ 35ci 79βr 482.9, 484.8; D EXAMPLE 6 Preparation of (+,-)-2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1-[[[1-[1-oxo-2-phenyl)ethyl]- 4-piperidinyl]amino]acetyl]piperazine Step 1. To a solution of 4-amino-1 -benzylpiperidine (9.5 g, δOmmol) in methanol (150 mL) at -10°C was added a solution of di-t- butyldicarbonate (10.9 g, 50 mmol ) in methanol (60 mL). The mixture was gradually warmed to room temperature overnight. After the reaction was complete, solvent was removed to give a white solid 2, FAB MS [M+1]+35cι 291.3 1 2 3 Step 2. To a soultion of compound 2 (11.6 g, 40 mmol) in methanol (140 mL) was added Pd(OH)2(20% on carbon ) (2.4 g) and hydrogenolyzed at 47 psi. After the reaction was complete, the catalyst was filtered off. The filtrate was evaporated to give compound 3 (8 g, 40 mmol) as a white solid, Step 3. Compound 3 (0.69 g, 3 mmol) was mixed with phenylacetyl chloride (0.46 g,3 mmol) and Hϋnig's base (0.43 g, 3.3 mol) in CH2CI2 (10 mL) at -5 °C and the solution was gradually warmed to RT overnight. After completion the reaction was diluted with CH2CI2 (50 mL) and washed with brine (30 mL, 3x). The CH2CI2 layer was dried over MgSθ4, filtered, and concentrated to give compound 4) as a white solid (0.81 g). Step 4. This crude material was dissolved in dry CH2CI2 (3 mL) and treated with 4N HCI-dioxane (6 mL). After stirring at RT for 2 h, solvents were evaporated to give 4-amino-1-(1-oxo-2-phenylethyl)piperidine 5 (0.8 g) as a white solid HCl salt. FAB MS [M+1]+ 219. Step 5. To a solution of compound 5 (0.31 g, 1.2 mmol) in CH2CI2 (10 mL) was added Hϋnig's base (0.62 g, 4.8 mmol) followed by the addition of compound 6 (0.3 g, 0.6 mmol) (prepared in Example 3). The mixture was stirred at RT for 5 days under N2. After completion the reaction was diluted with CH2CI2 (50 mL) and washed with brine (30 mL x2), dried over MgSθ4, filtered and concentrated to give a brown gummy crude material (0.56 g). This crude material was purified by silica gel chromatography on flash grade silica (60 g), eluting with 5% [NH4OH / MeOH (1 :9)] / 95% CH2CI2 to give the title compound as a white solid (0.28 g, 0.45 mmol) in 75% of yield. FAB MS [M+1J+ 35cι 621.1 ; m.p.87-89 <>C. EXAMPLE 7 Preparation of - 2 3 To a solution of N-t-butoxycarbonyl-4-piperidone 1 (15 g, 75.3 mmol) in pyridine (50 mL) was added hydroxylamine • HCl (5.23 g, 75.3 mmol). The mixture was heated in an oil bath at 65 °C for one hour. After cooling, pyridine was removed under reduced pressure and the residue was dried under high vacuum overnight to give a solid. To this solid was added water (100 mL) and the mixture was sonicated. The precipitate was filtered and washed with water then dried under high vacuum to give the oxime derivative of compound 1 (10.5 g, 65%). FAB MS [M+1]+ 215.3. The oxime compound (10 g, 46.67 mmol) was dissolved in absolute EtOH (100 mL) followed by the addition of Raney Ni (29 g, washed with absolute EtOH). The mixture was hydrogenated in a Parr shaker at 50 psi overnight. After reaction was complete, the Raney Ni was filtered off (caution risk of fire) and the filtrate was concentrated to give compound 2 (9.2 g, 46 mmol,98% yield) as an oil which solidified under high vacuum drying. FAB MS [M+1]+ 201.3. To a solution of bromoacetyl derivative 3 (3.0g,6.2 mmol) (prepared in Example 3) in CH2CI2 (62 mL) at -10 °C were added Hϋnig's base (1.2 mL, 6.82 mmol) and compound 2 (2.48 g, 12.39 mmol). The solution was gradually warmed to RT overnight. After reaction was complete, CH2CI2 (300 L) was added and washed with brine (100 L, 3x), dried over MgS04 and filtered. The filtrate was evaporated to dryness to give a light yellow solid which was purified by flash chromatography on flash grade silica gel (200 g), eluting with 5% [NH4θH/MeOH (1 :9)] / CH2CI2 to give 71 % yield of the title compound 4 as a white solid (2.66 g, 4.4 mmol), m.p. 78-81 °C; FAB MS [M+1]+35ci 603.1 ; Calcd. for C31 H40N4O4CI2, C, 61.69; H, 6.68; N.9.28; Cl,11.74. Found: C, 61.33; H, 6.94; N, 9.17; Cl, 11.27. EXAMPLE 8 Preparation of (-)-1 ,1-dimethylethyl 4-[[2-[2-(3,4-dichlorophenyl)-1-(3,5-dimethylbenzoyi)-1 - piperazinyl]-2-oxoethyl]amino]-1 -piperidinecarboxylate (Enantiomer B) By employing methods analogous to those described in Example 7 using chiral bromoacetyl compound (prepared in Example 5), the title compound was obtained as a white solid, m.p.72-75 °C; FAB MS [M+1]+35ci 603.2; 22°C [α] =-32.8°(MeOH). EXAMPLE 9 Preparation of (+,-)-2-(3,4-dichlorophenyl)-4-[3,5-dimethylbenzoyl]-1-[(4- piperidinylamino)acetyl]piperazine, dihydrochloride To a solution of (+,-)-1 ,1-dimethylethyl-4-[[2-[2-(3,4-dichlorophenyl)- 1 -(3,5-dimethylbenzoyl)-1 -piperazinyl]-2-oxoethyl]amino]-1 -piperidinecarboxylate (Example 7) ( 2.5 g, 4.14 mmol) in CH2CI2 (20 mL) at 0 °C was added 4N HCI- dioxane (10.35 mL, 41.4 mmol). The mixture was stirred at 0 °C for 1 h and it was gradually warmed to RT over 3 h. After reaction was complete, excess HCl and solvent were evaporated to give a pale yellow solid which was used without further purification. FAB MS [M+1]+ 35Q 503.1 EXAMPLE 10 Preparation of (-)-2-(3,4-dichlorophenyl)-4-[3,5-dimethylbenzoyI]-1-[(4-piperidinyl- amino)acetyl]piperazine, dihydrochloride (Enantiomer B) By employing method analogous to that described in Example 9 using chiral material obtained from Example 8, the title compound was obtained 22.1°C ft [άl = -38°(MeOH) as a pale yellow solid, FAB MS [M+1]+ 35ci 503.2; D EXAMPLE 11 A series of Y derivatives of (-)-2-(3,4-dichlorophenyl)-4-[3,5- dimethylbenzoyl]-1-[(4-piperidinylamino)acetyl]piperazine, dihydrochloride (Enantiomer B) was prepared by parallel synthesis. To a suspension of compound 1 obtained from Example 10 (1.05 g, 1.822 mmol) in CH2CI2 (40 mL) was added Hϋnig's base (1.0 mL 5.74 mmol). The mixture was dissolved by sonication. This solution was divided into 20 parts and transferred into 20 vials. Each vial contained 2-(3,4-dichlorophenyl)-4-[3,5- dimethylbenzoyl]-1-[(4-piperidinylamino)acetyl]piperazine, dihydrochloride (Enantiomer B) (0.091 mmol), Hϋnig's base (0.287 mmol) and CH2CI2 (2 mL). To each vial was added separately 0.1 mmol of aromatic or substituted aromatic methyl chloride or bromide or heterocyclic halide reagent. After reaction was complete it was diluted with CH2CI2 (5 L), washed with brine (2 mL 3x), dried (MgSθ4), filtered and evaporated to dryness. Representative compounds 2 made by the above routes are shown below. FAB MS FAB MS [M+1]+ 35 CI [M+1] + 35 CI ^ftoH EXAMPLE 12 Preparation of (+,-)-1 -benzoyl-4-[[2-[2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1 ■ piperazinyl]-2-oxoethyl]amino]piperidine To a solution of compound obtained from Example 9 (0.23 g, 0.4 mmol) in CH2CI2 (5 mL) was added Hϋnig's base (0.13 g, 1.0 mmol). This was followed by the addition of benzoic acid (49 mg, 0.4 mmol), HOBT (54 mg, 0.4 mmol), Et3N (40 mg, 0.4 mmol) and DEC (77 mg, 0.4 mmol) at 0 °C. The solution was gradually warmed to RT and stirred overnight. After reaction was complete, the solution was diluted with CH2CI2 (50 mL) and washed with saturated NaHCθ3 solution (30 mL, 2x) and brine (20 mL, 3x). The organic layer was dried over MgSθ4, filtered and concentrated to give crude material as an oil. The product was purified by chromatography on flash grade silica gel (50 g), eluting with 5% [NH4θH/MeOH (1 :9)]/ CH2CI2 to give the title compound as a white solid (0.18 g), m.p. 94-96 °C; FAB MS [M+1J+ 35ci 607.3. EXAMPLE 13 Preparation of (+,-)-2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1-[[[1-(2-oxo-2-phenylethyl)- 4-piperidinyl]amino]acetyl]piperazine °V Br HOnig's base To a solution of compound 1 obtained from Example 9 (0.23 g, 0.4 mmol) in CH2CI2 (5 mL) were added Hϋnig's base (0.21 g, 1.6 mmol) and phenylacyl bromide (80 mg, 0.4 mmol) at RT. The mixture was stirred at RT overnight under N2. After reaction was complete, it was worked up and purified according to the methods described in Example 7 to give the title compound 2 as a solid, m.p. 69-71 °C; FAB MS [M+1J+ 35 ci 621.3. EXAMPLE 14 Preparation of (+,-)-2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1-[[[1-(3-phenylpropyl)-4- piperidinyl]amino]acetyl]piperazine To a solution of compound 1 obtained from Example 9 (0.4 g, 0.7 mmol) in CF3CH2OH (5 mL) was added Hϋnig's base (0.21 g, 1.6 mmol) at 0 °C. After stirring at 0 °C for 10 min, hydrocinnamaldehyde (94 mg, 0.7 mmol) was added. The reaction was stirred at 0 °C for additional 2.5 h, and NaBH3CN (100 mg, 1.6 mmol) was added. The mixture was stirred at 0 °C and gradually warmed to RT overnight. After reaction was complete, it was worked up and purified as described in Example 7 to give the title compound as a white solid, m.p. 52-54 °C; FAB MS [M+1J+ 35ci 621.3. EXAMPLE 15 Preparation of (-)-N-[4-[[4-[[2-[2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1-piperazinyl]-2- chiral target chiral 1 2 By an analogous method to that described in Example 13, using the chiral intermediate 1 made in Example 10 and 2-acetamido-4-(chloromethyl)- thiazole, in the present of Hϋnig's base in CH2CI2, the title compound 2 was obtained as a white solid after purification by flash grade silica gel chromatography, m.p. 104-107 °C, HRMS Calcd. for [M+H+] (2x35)cι [cd = -40.1° (MeOH). C32H39N6SO3CI2 657.2181 ; Found 657.2172; D EXAMPLE 16 Preparation of (+,-)-2-(3,4-dichlorophenyl)-4-[3,5-dimethylbenzoyl]-1-[[[3-methyl-1- (phenylmethyl)-4-piperidinyl]amino]acetyl]piperazine (diastereomers A and B) Step l To a solution of BOC glycine (0.979 g, 5.59 mmol) and Et3N (0.85 mL, 6.1 mmol) in CH2CI2 (10 mL) was added BOP (benzotriazol-1-yloxy- tris(dimethylamino)phosphonium hexaf luorophosphate) reagent (2.46 g, 5.57 mmol). After stirring for 15 min, (+,-)-(3,5-dimethylbenzoyl)-3-(3,4- dichlorophenyl)piperazine (1.83 g, 5.03 mmol) (prepared in Example 2) was added. After 5 h, the reaction mixture was added to 0.2 N HCl (100 mL) and extracted with CH2CI2 (3 x 60 mL). The combined organic layers were washed with brine, dried with MgS04 and concentrated. The crude material was purified by flash chromatography on silica gel eluting with 50:1 to 30:1 CH2Cl2-MeOH to give 2.15 g of compound 2 (shown above) as a white foam (4.1 mmol, 82%). Step 2 Compound 2 (1.32 g, 2.5 mmol) was treated with MeOH saturated HCl (15 mL) for 2.5 h and concentrated. The resulting powder was dissolved in CH2CI2, washed with sat. NaHCθ3, dried with MgS04 and concentrated to give compound 3 as the free base. Step 3 To a -78°C solution of LDA (10.79 mmol) in THF (30 mL) was added 1-benzyl-4-piperidone (2.0 mL, 10.8 mmol). The reaction mixture was warmed to 0°C for 20 min and then cooled back to -78°C. Methyl iodide (0.67 mL, 10.8 mmol) was added to the enolate solution which was stirred at 0°C for 2 h then warmed to RT overnight. The reaction mixture was quenched with sat. NH4CI and concentrated. The residue was suspended in H2O and extracted with CH2CI2. The combined organic layers were dried with MgS04, filtered and concentrated. The product was purified by flash chromatography on silica gel eluting with 1 :1 hexane-EtOAc to give the 1 -benzyl-3-methyl-4-piperidone 4 as a yellow oil (0.65 g, 30%). Step 4 A mixture of the ketone 4 from step 3 (70 mg, 0.13 mmol) and the compound 3 (34 mg, 0.17 mmol) was stirred in titanium isopropoxide (45 mg, 0.16 mmol) for 1.5 h. To the mixture were added ethanol (1.0 mL) and NaCNBHβ (5.4 mg, 8.6 mmol) and the mixture was stirred overnight. The reaction mixture was filtered and washed with EtOAc. The filtrate was washed with H2O and brine, dried with MgSθ4 and concentrated. The residue was chromatographed on silica gel eluting with 5% NH3 sat. MeOH in CH2CI2 to give both diastereomers pure. Diastereomer A (15 mg) HRMS (FAB, M+H + ): m/e calc'd for [C34H4iN 4 Cl2θ2] + 607.2607; found 607.2603. Diastereomer B (17 mg) HRMS (FAB, M+H+): m/e calc'd for [C34H41N 4 CI2O2 607.2607; found 607.2597. EXAMPLE 17 Preparation of 2-(3,4-dichlorophenyl)-4-[3,5-dimethylbenzoyl]-1-[[[1-(phenylmethyl)-3- piperidinyl]amino]acetyl]piperazine, diastereomers By a procedure analogous to the method described in Example 16 step 4, using 3-benzyl piperidine in place of 1-benzyl-3-methyl-4-piperidone, the title compound was prepared as a solid foam. HRMS (FAB, M+H+): m/e calc'd for [C33H39N4Cl2θ2] + 593.2450; found 593.2458. EXAMPLE 18 Preparation of 2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1-[[[8-(phenylmethyl)-8- azabicyclo[3.2.1]oct-3-yl]amino]acetyl]piperazine compoun By an analogous method to that described in Example 16, the product from Example 16, compound 3 (185 mg, 0.44 mmol) was combined with 8-benzyl-8-azabicyclo[3.2.1]octan-3-one (97 mg, 0.45 mmol) and Ti(0-/ Pr)4 (105 mL, 0.50 mmol) and left stirring for 1 h. To the thick reaction mixture was added NaBHsCN (59.5 mg, 0.95 mmol) and the mixture was stirred overnight. To the reaction mixture was added H 2 O (1 mL) and it was filtered. The filtrate was washed with EtOH, concentrated and purified by silica gel chromatography, eluting with 30:1 :0.1 to 15:1 :0.1 CH2Cl2-MeOH-NH3 aq. to give the title product as a white foam. HRMS (FAB, M+H+); m/e calc'd [C35H4iCl2N θ2] + : 619.2607, found 619.2594. EXAMPLE 19 Preparation of 2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1-[[[8-methyl-8- azabicycl O [3.2. 1 ] O c..3.yl]amiπo]acβ^0p i p < βrazine (enantiomer B) This compound was prepared by a procedure analogous to Example 16 except for the use of (+)-[3,5-dimethylbenzoyl]-3-(3,4-dichlorophenyl)- piperazine (Enantiomer B) in stepl and tropinone in place of 1-benzyl-3- methyl-4-piperidone. HRMS (FAB, M+H+); m/e calc'd [C29H 37012^02]+: 543.2294, found 543.2282. EXAMPLE 20 Preparation of 2-(3,4-dichlorophenyl)-4-[3,5-dimethylbenzoyl]-1-[[[1 ,3-bis(phenylmethyl)-4- piperidinyl]amino]acetyl]piperazine, diastereomers from enantiomer B Step 1. A solution of 1-benzyl-3-carbomethoxy-4-piperidone (1.0 g, 4.0 mmol) in THF (10 mL) was treated with 0.5 M potassium bis(trimethylsilyl)amide in toluene (9.6 mL, 4.8 mmol) for 15 min, followed by the addition of benzyl bromide (1.2 g, 4.8 mmol). After 2 h, the reaction mixture was quenched with sat. NH4CI and extracted with ether. The combined organic layers were washed with brine, dried with MgSU 4 and concentrated. The product was purified by silica gel chromatography eluting with 4:1 hexane-EtOAc to give 3-carbomethoxy-1 ,3-dibenzyl-4-piperidone (0.61 g) as a light yellow oil. Step 2. A solution of 3-carbomethpxy-1,3-dibenzyl-4-piperidone (0.61 g, 1.78 mmol), MeOH (10 mL) and 5 M HCl aq. (25 mL, 125 mmol) was refluxed overnight. The reaction mixture was concentrated and chromatographed (silica gel, eluting with 4:1 hexane-EtOAc) to give 1 ,3- dibenzyl-4-piperidone (0.31 g). Step 3. A solution of 1 ,3-dibenzyl-4-piperidone (0.033 g, 0.12 mmol) and [[2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1-amino]acetyl]-piperiazine (Enantiomer B) (0.05g, 0.12 mmol) [prepared according to the methods described in Example 16, except using (+)-[3,5-dimethylbenzoyl]-3-(3,4- dichlorophenyl)piperazine (Enantiomer B) (Example 4) in step 1] in CH2CI2 (1.0 mL) was treated with NaBH(OAc)3 (0.035 g, 0.16 mmol) and acetic acid (0.07 mL, 0.12 mmol). The mixture was stirred overnight. After completion, the reaction mixture was quenched with 1 N NaOH and extracted with CH2CI2. The combined organic extracts were washed with brine, dried with MgSθ4, concentrated and purified by silica gel chromatography, eluting with 5% NH3 sat. MeOH/CH 2 Cl2 to give 32 mg of the titled product as a white solid. HRMS (FAB, M+H+); m/e calc'd [C4θH45Cl2N 4 θ2]+: 683.2920, found 683.2932. EXAMPLE 21 Preparation of 2-(3,4-dichlorophenyl)-4-[3,5-dimethylbenzoyl]-1 -[[[3-methyl-1 - (phenylmethyl)-4-piperidinyl]amino]acetyl]piperazine (diastereomers A from enantiomer B) This compound was prepared by a procedure analogous to Example 16 except for the using of (+)-[3,5-dimethylbenzoyl]-3-(3,4-dichlorophenyl)- piperazine (Enantiomer B) in Example 16, step 1. HRMS (FAB, M+H+); m/e calc'd [C34H4iCI N4θ2] + : 607.2607, found 607.2594. EXAMPLE 22 Preparation of 2-(3,4-dichlorophenyl)-4-[3,5-dimethylbenzoyl]-1-[[[1-(phenylmethyl)-3-(2- propenyl)-4-piperidinyl]arnino]acetyl]piperazine (diastereomers from enantiomer B) This compound was prepared by a procedure analogous to Example 20 except for the substitution of allyl bromide in place of benzyl bromide in step 1. HRMS (FAB, M+H + ); m/e calc'd [C 3 6H43Cl2N 4 θ2] + : 633.27, found 633.2763. EXAMPLE 23 Preparation of trichloroethyl-4-[[2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1 - piperazi ny l]-2-oxoethy l]ami no]-2-pheny I- 1 -piperidi necarboxy late (diastereomers from enantiomer B) Step 1. To a cooled solution of THF (100 mL) containing 4- methoxypyridine (3.5 g, 32.5 mmol) (prepared according to Synthesis ^989, 645, at -15°C was added 2,2,2-trichloroethyl chloroformate (4.5 mL, 32.7 mmol). After 30 min. at -15°C, 2M PhMgCI in THF (19.5 mL, 39 mmol) was added and the mixture was stirred at -15°C for 30 min. followed by 30 min. at RT. The reaction mixture was quenched with 10% aq. HCl (100 mL), added to brine (200 mL) and partitioned. The aqueous layer was extracted with Et ∑ O (50 mL). The combined organic layers were dried with MgS04 and concentrated to give 11.4 g of compound 3 shown above as a light tan solid. Step 2. To a cooled solution of compound 3 from step 1 (8.65 g, 34.8 mmol) in THF (100 mL) at -23°C was added 27.8mL of 1 M L-selectride (27.8 mmol). The mixture was stirred at -23°C for 2 h. After warming to RT, the reaction mixture was added to sat. NaHCθ3 and partitioned. The aqueous layer was extracted with E.2O (2 x 50 mL). The combined organic layers were washed with brine (50 mL), dried with MgS04 and concentrated. The product was purified by silica gel chromatography eluting with 6:1 to 3:1 hexane-EtOAc to give 2.47 g of compound 4 and 2.75 g of recovered starting material. Step 3. To a solution containing the compound 4 from step 2 (284 mg, 0.81 mmol) in 1 ,2-dichloroethane (3 ml) and compound 5 (324 mg, 0.81 mmol) [made in Example 16, step 3 except using (+)-[3,5-dimethylbenzoyl]- 3-(3,4-dichlorophenyl)piperazine (Enantiomer B) in step 1] was added NaBH(OAc)3 (179 mg, 0.84 mmol) and acetic acid (50 mL, 0.87 mmol). After stirring overnight, the reaction mixture was added to 1N NaOH (40 mL) and was extracted with Et2θ (3 x 15 mL). The combined organic layers were washed with brine (15 mL), concentrated, and purified by silica gel chromatography eluting with 25:1 :0.1 CH2Cl2-MeOH-NH3 aq to give 423 mg of the title compound as a white foam. HRMS (FAB, M+H+); m/e calc'd [C35H38Cl4N 4 θ4] + : 753.1336, found 753.1338. EXAMPLE 24 Preparation of 2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1-[3-[5-(phenylmethyl)- (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-yl]-1-oxopropyl]piperazine (diastereomer A from enantiomer B) To a cooled solution of CH2CI2 (10 mL) containing diisopropylethylamine (0.275 mL, 2.0 mmol) and [3,5-dimethylbenzoyl]-3- (3,4-dichlorophenyl)piperazine (Enantiomer B) (Example 4) (305 mg, 0.84 mmol) was added chloropropionyl chloride (0.075 mL, 0.8 mmol). The reaction mixture was allowed to warm to room temperature. After 20 minutes, (1S,4S)-2-benzyl-2,5-diazabicyclo(2.2.1)heptane-2HBr (297 mg, 0.85 mmol) and diisopropylethylamine (0.275 mL, 2.0 mmol) were added and the mixture was left over night, after which the reaction mixture was concentrated. The product was purified by flash chromatography on flash grade silica gel, eluting with 30:1 :0.1 CH2Cl2/MeOH/NH3 to give a foamy solid (140 mg, 0.23 mmol, 29%), High Res. MS:[M+1] + calcd. for C34H39CI2N4O2 605.2450; Found, 605.2465. EXAMPLE 25 Example l 0 y " aromatic or substituted chjrai aromatic or cycloalkyl group y = aromatic or substituted aromatic or cycloalkyl group A series of urea analogs of (-)-2-(3,4-dichlorophenyl)-4-[3,5- dimethylbenzoyl]-1-[(4-piperidinyl-amino)acetyl]piperazine, dihydrochloride (Enantiomer B) (Example 10) as shown above was prepared by parallel synthesis. The product from Example 10 (0.75 g, 1.3 mmol) was dissolved in dry pyridine (13 mL). 1 ml of the above solution was transfered into a vial (2 dram size). To each vial was added 0.1 mmol of an aromatic or substituted aromatic isocyanate reagent. After completion the reaction was diluted with CH2CI2 (5 mL) and washed with water (3x5 mL), dried over Na2S04, filtered and evaporated to dryness. Most of reactive reagents gave (2:1 ) adduct B as the major product. Several less reactive reagents gave the product A. Crude products were identified by FAB MS. FAB MS _ Λ _ FAB MS Product [M+1]+ * cι Product [M+1] +35CI i τ r CHa 9.3 B 797 T B 76 CH3 ! τθτ CN 647.3 EXAMPLE 26 from Example 10 * - aromatic or substituted chiral aromatic or heterocyclo group A series of amido analogs of (-)-2-(3,4-dichlorophenyl)-4-[3,5- dimethylbenzoyl-1 -[(4-piperidinyl-amino)acetyl]piperazine, dihydrochloride (Enantiomer B) (Example 10) shown above were prepared by parallel synthesis. The chiral product from Example 10 (1.15 g, 2 mmol) was dissolved in a mixture of dry CH2CI2 (20 mL) and Hϋnig's base (0.9 g, 7 mmol) followed by the addition of HOBT (0.3 g, 2.2 mmol). After stirring at RT for one hour, 1 mL of this solution was transfered into a brown vial (4 dram size). To each vial was added the appropriate aromatic or heterocyclic acid (0.1 mmol). DEC (0.38 g, 2 mmol) was dissolved in CH2CI2 (5 mL) and Et3N (0.2 mL) and 0.4 mL(0.2 mmol) of this DEC solution was added into each vial. The reaction was stirred at RT overnight. After completion each reaction mixture was diluted with CH2CI2 (4 mL) and washed with water (2 x 4 mL), dried over Na2S04, filtered and evaporated to dryness. Crude product was identified by FAB MS. chiral target cι cι y = aromatic or substituted aromatic or hetercyck) group EXAMPLE 27 Preparation of (-)-phenyl 4-[[2-[2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1-piperazinyl-2- oxoethyl]amino]-1-piperidinecarboxylate, hemihydrate (Enantiomer B) 1 chiral To a cold solution of compound 1 from Example 10 (0.2 g, 0.347 mmol) in CH2CI2 (8 mL) at -78 °C was added Hϋnig's base (0.193 mL, 1.11 mmol) and phenylchloroformate (0.046 mL, 0.364 mmol). After stirring at -78 °C for 24 h, the reaction was diluted with CH2CI2 (200 mL), washed with brine (80 mL, 3x), dried (MgS04), filtered and evaporated to dryness. The crude material was purified by flash chromatography, using flash grade silica gel (50 g), eluting with 5% [(1 :9) (NH4OH / MeOH)] / 95% CH2CI2 to give a 50% yield of the title compound 2 as a white solid (0.108 g, 0.173 mmol), m.p. 71-75 °C; FAB MS [M+1]+ 35ci 623.0; Calcd. for C33H36N4O4CI2 • 0.5 H2O, C, 62.66;H, 5.90; N, 8.86; Cl 11.38. 24.2°C W _, = -42.0° (MeOH). Found: C, 62.52; H, 5.95; N, 8.87; Cl, 11.01 ; D EXAMPLE 28 Preparation of 2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1 -[[[1 -[(1 H-pyrrol-2-yl)methyl]-4- piperidinyl]amino]acetyl]piperazine, hemihydrate (Enantiomer B) N CaFB 3C H H 3C 2 O N H 1 2 chiral To a solution of compound 1 from Example 10 (0.2 g, 0.347 mmol) in CF3CH2OH (3.47 mL) was added Hϋnig's base (0.12 mL, 0.694 mmol) and pyrrole-2-carboxaldehyde (40 mg, 0.42 mmol) at RT under nitrogen. After stirring at RT for 1 h, NaBH3CN (67 mg, 0.694 mmol) was added and the mixture was stirred overnight. After the reaction was complete, solvent was evaporated and the residue was mixed with 5% NaHC03 solution (50 mL) and brine (100 mL) then it was extracted with CH2CI2 (80 mL,3x). The organic layers were combined, dried (MgS04), filtered and evaporated to dryness. The crude material was purified by flash chromatography on flash grade silica gel (50 g), eluting with 7.5% [(1 :9)(NH4θH / MeOH)] / 92.5% CH2CI2 to give the title compound 2 in 43% of yield as a white solid, m.p.73-76 °C; HRMS , Calcd. for [M+H+] 35 c , C31H38N5O2CI2 : 582.2403 Found: 582.2403. EXAMPLE 29 Preparation of 2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1 -[[[1 -[(1 H-pyrrol-2-yl)carbonyl]-4- piperidinyl]amino]acetyl]piperazine, hemiihydrate (Enantiomer B) 1 2 chiral By an analogous method to that described in Example 26, using the chiral compound 1 from Example 10 (100 mg, 0.173 mmol) and pyrrole-2-carboxylic acid (20 mg, 0.178 mmol), the title compound 2 was obtained as a white solid after flash grade silica gel chromatography, m.p. 95-100 °C; HRMS, Calcd. for [M+H+] 35 ci, C31H36N5O3CI2 : 596.2159 Found: 596.2204. EXAMPLE 30 Preparation of (-)-2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1 -[[[1 -[(1 H-imidazol-2- yl)methyl]-4-piperidinyl]amino]acetyl]piperazine, dihydrate (Enantiomer B) M ° CF3CH2OH chiral By an analogous method to that described in Example 28, using the chiral compound 1 from Example 10, (200 mg, 0.347 mmol) and 2-imidazole- carboxaldehyde (34 mg, 0.347 mmol), the title compound 2 was obtained as a white solid after flash grade silica gel chromatography, m.p. 73-76 °C; HRMS , Calcd. for [M+H+] 35ci, C30H37N6O2CI2 : 583.2355 Found: 583.2369; , ,23.7°C W D = -46.5°(MeOH) Example 31 Preparation of 2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1 -[1 -oxo-3-[[1 - (phenylmethyl)-4-piperidinyl]amino]propyl]piperazine (Enantiomer B) Step 1. To a cold solution of [3,5-dimethylbenzoyl]-3-(3,4- dichlorophenyl)piperazine (Enantiomer B)1 (3.0 g, 8.26 mmol) (Example 4) in CH2CI2 (82.6 mL) at -78 °C was added Hϋnig's base (1.582 mL, 9.08 mmol) and bromopropionyl chloride (0.874 mL, 8.67 mmol). After stirring at -78 °C for 5 h, the reaction mixture was diluted with CH2CI2 (300 mL), washed with brine (150 mL, 2x), dried with MgSθ4, filtered and concentrated to dryness to give the crude bromopropionyl intermediate 2 (3.2 g). Step 2. To a solution of compound 2 (300 mg, 0.6 mmol) in CH2CI2 (6 mL) were added 4-amino-1 -benzyl piperidine (0.245 mL, 1.2 mmol) and Hϋnig's base (0.1 mL, 0.6 mmol) at 0 °C. The reaction was gradually warmed to RT and stirred for 3 days. After completion the reaction mixture was diluted with CH2CI2 (200 mL) and washed with brine (50 mL, 2x), dried over MgSθ4, filtered and concentrated to dryness to give a light yellow solid. The crude material was purified by flash chromatography on flash grade silica gel (80 g), eluting with 6.5% [(1 :9) (NH4OH / MeOH)] / 93.5% CH2CI2 to give the title compound as a white solid (0.18 g, 0.3 mmol, 50%), m.p. 51-54 °C; HRMS, Calcd. for [M+H+] 35 ci, C34H41N4O2CI2 : 607.2607 Found: 607.2600. EXAMPLE 32 Preparation of 2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1 -[1 -oxo-3-N-methyl-[[1 (phenylmethyl)-4-piperidinyl]amino]propyl]piperazine (Enantiomer B) 4-Methylamino-1 -benzyl piperidine 3 was prepared analogous to the reductive amination method described in Example 28 using 4-amino- 1 -benzyl piperidine and methylamino hydrochloride as starting materials. The title compound 4 was prepared as a white soid, analogous to the methods described in Example 31 , except using 4- methylamino-1 -benzyl piperidine 3 in place of 4-amino-1 -benzyl piperidine in step 2. m.p. 47-49 °C; FAB MS [M+1]+ 35ci 621.2; Calcd. for C35H42N4O2CI2 • 0.5 H2O: C, 66.66; H, 6.87; N, 8.88; Cl, 11.24. Found: C, 67.02; H, 7.07; N, 8.81 ; Cl, 10.75. EXAMPLE 33 Preparation of (-)-1 ,2-dimethylethyl 5-[3-[2-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1 - piperazinyl]-3-oxopropyl]-(1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2- carboxylate (diastereomer A from enantiomer B) chiral Example 4 The title compound 4 was prepared as a white solid analogous to the methods described in Example 31 except using (1s,4s)-N-t-BOC-2,5- diazobicyclo[2.2.1]-heptane in place of 4-amino-1 -benzyl piperidine in step 22.0°C n = -5i.i°(MeOH). 2. m.p.78-82 °C; FAB MS [M+1]+ 35 ci 615.1 ; D Example 34 Preparation of (-)-1-[3-(1S,4S)-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-1-oxopropyl]-2-(3,4- dichlorophenyl)-4-(3,5-dimethylbenzoyl) piperazine dihydrochloride (diastereomer A from enantiomer B) To a solution of compound 1 obtained from Example 33 (0.74g, 1.2 mmol) in CH2CI2 (6 mL) at RT was added 4N HCl (3mL, 12 mmol). After stirring at RT for 4 h, excess acid and solvents were evaporated to give a light yellow solid 2, m.p. 60-64 °C; FAB MS [M+1]+ [0. = -34.4°(MeOH). 35d 515.1 ; D Example 35 Preparation of (-)-N-[4-[[5-[3-[2-(3,4-dichlorophenyl-4-(3,5-dimethylbenzoyl]-1-piperazinyl]- 3-oxopropyl]-(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl-2- thiazolyl]]acetamide (diastereomer A from enantiomer B) By an analogous method to that described in Example 13, using the chiral intermediate 1 made in Example 34 and 2-acetamido-4- chloromethyl thiazole, in the present of Hϋnig's base in CH2CI2, the title compound 2 was obtained as a white solid 2 after purification by flash grade silica gel chromatography, m.p. 105-110 °C; FAB MS [M+1]+ 35 ci 669.0; [o ' = -23.4°(MeOH). EXAMPLE 36 Preparation of (-)-N-[4-[[5-[3-[2-(3,4-dichlorophenyl-4-(3,5-dimethylbenzoyl]-1-piperazinyl]- 3-oxopropyl]-(1 S,4S)-2,5-diazabicyclo[2.2.1 ]heptan-2-yl]methyl]phenyl] acetamide (diastereomer A from enantiomer B) By an analogous method to that described in Example 13, using the chiral intermediate made in Example 34 and 4-acetamidobenzyl chloride, in the present of Hϋnig's base in CH2CI2, the title compound 2 was obtained as a white solid after purification by flash grade silica gel chromatography, m.p. 101-106 °C; FAB MS [M+1]+ 35ci 662.1 ; [a] ' = -27.3°(MeOH). EXAMPLE 37 Preparation of 2-(3,4-dichlorophenyl-4-(3,5-dimethylbenzoyl]-1-[3-[5-(1H-pyrroll-2- yl)methyl]-(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-1-oxopropyl] piperazine (diastereomer A from enantiomer B) By an analogous method to that described in Example 28, using the chiral intermediate of Example 34, the title compound 2 was obtained as a white solid after purification by flash grade silica gel chromatography, m.p. 81-83 0 C; FAB MS [M+1]+ 35ci 594.1 EXAMPLE 38 Preparation of (+,-)-2-(3,4-dichlorophenyl)-4-[(4-fluoro-1 -naphthalenyl)carbonyl]-1 -[[[1 - (phenylmethyl)-4-piperidinyl]amino]acetyl]piperazine Ar 1 Ph General Method To a cooled solution of (+,-)-2-(3,4-dichlorophenyl)piperazine (1 ; Ar = 3,4-dichlorophenyl) (20g, 86.53 mmol) in MeOH (900 mL) at -78 °C was added dropwise a solution of t-BOC anhydride (19.47g, 86.53 mmol) in MeOH (263 mL) over 3h period under N2. The solution was gradually warmed up to RT overnight. After reaction was complete, the solvent was evaporated and the residue was dried under high vacuum overnight to give 2 (28 g) as a white solid. (Ar 2 = 3,4-dichlorophenyl) FAB To a cooled solution of compound 2 (23.8g, 71.85 mmol) in CH2CI2 (500 mL) at -78 °C was added a solution of bromoacetylbromide (6.88 mL, 79.04 mmol) in CH2CI2 (10 mL) through a dropping funnel under N2 over a 10 min. period. After stirring at -78 °C for 3 h, TLC showed that the reaction was complete. To this cooled solution were added Hϋnig's base (13.76 mL,79 mmol) and 4-amino-1-benzylpiperidine (29.30 mL, 143.7 mmol). It was kept at -78 °C for one hour then gradually warmed up to RT overnight. After completion CH2CI2 (200 mL) was added and washed with brine (200 mL, 3x), dried over MgSθ4, filtered and concentrated to give a light brown residue of compound 3 (46g) (Ar 2 = 3,4- dichlorophenyl). Compound 3 was purified by flash chromatography on 400g of flash grade silica gel, eluting with 3.5 % NH3-MeOH/CH2Cl2 to give 24.8 g (44.2 mmol, 61.5 %) of pure compound 3 (Ar 2 = 3,4- dichlorophenyl). FAB MS [M+1]+ 35ci 561.3 To a solution of compound 3 (Ar 2 = 3,4-dichlorophenyl) ( 16g, 28.49 mmol) in CH2CI2 (142.5 mL) at 0 °C was added 4N HCI-dioxane solution (71.24 mL, 284.9 mmol) through a dropping funnel. The reaction was gradually warmed up to RT and stirred for 4h. After completion the solvents were evaporated to give a light yellow solid which was dissolved in H2O (400 mL) and brought to pH 10 with 1 N NaOH. The product was extracted from basic aqueous solution with CH2θ2(200mL, 4x), dried over MgSθ4, filtered and concentrated to give compound 4 (Ar 2 = 3,4- dichlorophenyl) as a light yellow solid (12.5g, 27.09 mmol, 95%). FAB MS [M+1]+35 Cl 461.1 Compound 4 was the key intermediate which was used to couple with various aromatic acid for the synthesis of many compounds. To a solution of compound 4 (Ar 2 = 3,4-dichlorophenyl) (200 mg, 0.433 mmol) in CH2CI2 (5 mL) were sequentially added 4-fluoro-1- naphthoic acid (84.8 mg, 0.433 mmol), HOBT (58.5 mg, 0.434 mmol), Et3N (0.634 mL, 0.455 mmol) and DEC (85 mg, 0.434 mmol) at RT. The reaction was stirred at RT under N2 overnight. After completion the reaction was diluted with EtOAc (150 mL) and washed with brine (50 mL, 3x), dried over MgSθ4, filtered and concentrated to give a crude product 5 (Ar 2 = 3,4- dichlorophenyl, Ar 1 = 4-fluoro-1 -naphthyl) which was purified by flash chromatography ( 50 g flash grade silica gel), eluting with 4% sat'd NH3- MeOH in CH2CI2 to give pure compound 5 Fab Mass [M+1]+ 35Q ( 533.2, m.p.78-81 °C. EXAMPLE 39 The following compounds were prepared according to the procedures described in Example 38. The key intermediate compound 4 (Ar 2 = 3,4-dichlorophenyl) was coupled with the appropriate aromatic acid to obtain the target compounds. Those compounds without melting points were prepared via parallel synthesis. FAB and / or Cl MS [M+1]+ 35CI M.P. °C 1 χ37 CI) Calcd. for C37H 1 NsO≥Cfe • 3 HCl • 3 H2O 658 C, 54.06; H, 6.13; N, 8.52 Found: C, 54.28; H, 6.23; N.8.77 made pure from chiral enantiomer B intermediate 4 analogous to Example 38 Calcd. for C30H31 N5O 2 CU • 2 HCl • 2 H2O 614 C, 48.41 ; H, 5.01 ; N, 9.41 Found: C48.16; H, 5.41; N, 9.30 made pure from chiral enantiomer B intermediate 4 analogous to Example 38

Claims: WHAT IS CLAIMED IS: A compound of the formula: I each X is independently, O, (H,H), NRd, or S; n is 0 to 2; u is 0 to 2; I is 0 to 2; m is 1 , and y is 1 to 3; or m is 2, and y is 0; and with the further proviso that no more than one R c is other than H in the moiety; each R c is independently H, Ci-Cβ alkyl, -(CH 2 ) n 1 -R 4 where ni is 1 to 6; Rd is independently selected from the group consisting of H, Ci-Cβ alkyl, CN, OR a , phenyl, substituted phenyl, benzyl, substituted benzyl, or allyl; O Ra Rb O II I I ιι O-C — N-Rb , or — N-C-ORa R c ' is H, Ci-Cβ alkyl or (CH2) n 0R a , with the proviso that no more than one Rc* is other than H; each R a and Rb is independently selected from the group consisting of H, Ci-Cβ alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, b o i n allyl; with the proviso that when R4 is ~~ a , R a is not H; or when R a and Rb are attached to the same nitrogen, then R a and Rb together with the nitrogen to which they are attached, form a 4 to 7 member ring; wherein each Ri and R2 is independently H, C-i-Cβ alkyl, CF3, C2F5, Cl, Br, I, F, N0 2 , OR a , CN, NR a R b , " O Ra Rb O Ra O O O R a II I I II I II II II I — O— C-N— R — N-C-OR a — N-C-Rb — C-OR a — C — -Rb > I > » O Q o O n __ ll__ ^ _^ ^ S Ra , S "* , -SR a , and S NHRa ; and where R a is not H 0 q. 0 Rb o n 1 11 . -S— Ra -S— R a —N-C-ORa in , , or or when Ri and R2 are on adjacent carbons on a ring, they can form wherein n' is 1 or 2; and each R3 is independently H, C1 -Cβ alkyl, CF3, C2F5, C-Ra o O Ra n __. B __ -O— C-Ra f C N-R b cι Br l> F. OR g , OCF3, or phenyl; Aη is heteroaryl or substituted heteroaryl, Q is N or CH; AT2 is heteroaryl or substituted heteroaryl; Z iS mi = 0-1; ττi 2 = 1-2; n3 Is 0-4; Rg is -ORa with the proviso that R a is not H; aryl, substituted aryl, heteroaryl, substituted heteroaryl, -NR a Rb, -O-(CR a ,Rb) n 7-aryl, -O- (CR ,Rb) n 7-substituted aryl, -O-(CR a ,Rb) n 7-heteroaryl , -O-(CR a .Rb) n 7- substituted heteroaryl ,-NR a -(CR a ,Rb)n7-heteroaryl, -NR a -(CR a ,R b )n7- subst ' rtutθd heteroaryl, -O-(CR a ,Rb)n7-hθterocycloalkyl, -O-(CR a ,R b )n7- substituted hβterocyoloalkyl, -NRa-(CR a ,Rb)r»7-aryl, -NR a -(CR a ,Rb)n7- Θ7 substituted aryl, -NR a -(CR a ,Rb)n 7 -heterocycloalkyl, -NR a -(CR a ,Rb)nr substituted heterocycloalkyl; n 7 is 0 to 4; each R θ and Rf is independently selected from the group consisting of H, Ci-Cβ alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, allyl; or Re and Rf taken together with the carbon to which they are attached can also form a carbonyl group with the proviso that no more than one carbonyl group is in the moiety; n 5 is 1 to 2; each R5 is independently selected from the group consisting of H, OH, 0 II c Ra , C1-C6 alkyl, (CH2)m-R4, wherein ni is 1 to 6 with the proviso that when m is 1 , R4 is not OH or NR a Rb; also with the proviso that when ns is 2, R5 is Ot-Cβ alkyl and two R5 can be attached to the nitrogen to form a quaternary salt: e is H, C Cβ alkyl, C3-C6 cycloalkyl, 96 wherein X3 is (H,H), O, NRa, or S, or Rς is heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl when n3 is 0-4; when Re.Rf taken together with the carbon atom to which they are attached form a carbonyl group and n 3 is 1 , R 6 can also be -OR a wherein R a is not H, or R 6 is -NRa.Rb. -O-(CR a ,Rb)nrheteroaιyl, -O-(CR a ,Rb)n 7 -substituted heteroaryl, -O-(CR a ,Rb)n7-heterocycloalkyl, -O-(CR a ,Rb)n 7 -substituted heterocycloalkyl, -O-(CR a ,Rb)nraryl, -O-(CR a ,Rb)n 7 -substituted aryl, -NR a -(CRa,Rb)n7-heteroaryl, -NR a -(CRa,Rb)n7-substittrted heteroaryl, -NRa-(CRa,Rb)n7-aryl, -NR a -(CRa,Rb)n 7 -substituted aryl, -NR a -(CR a ,Rb)n 7 - heterocycloalkyl, -NRa-(CR a ,Rb)n 7 -substituted heterocycloalkyl, wherein R a and R are each independently selected from the group consisting of H and Oi-Cβ alkyl; or any enantiomer thereof, or a pharmaceutically acceptable salt thereof. 2. A compound according to claim 1 , wherein m is 1 ; both X's are O; I is 0; n is 1 ; u is 0; and y is 1 to 3; and Ar is wherein Q is N or CH; each Xi is independently O, S or NR a; each X2 is independently CH or N; and n4 is 0 or 1 ; and wherein Ar2 is 3. A compound according to claim 2 wherein Z is 4. A compound according to claim 2 wherein Z is 5. A compound according to claim 2 wherein Z is 6. A compound according to claim 2 wherein Re, or Rf is H or Ci-Cβ alkyl or allyl, n 3 is 0-4, n7 is 0 to 4; and Re 'S R, ■ C r C 6 alkyl ι____ cycloalkyl, or wherein Re, Rf taken together with the carbon to which they are attached form a carbonyl group , n 3 is 1 and RQ is -0-(CR a ,Rb)n7-L, wherein L is ξ — O- cycloalkyl, or wherein Re.Rf taken together with the carbon to which they are attached form a carbonyl group , n 3 is 1 and R& is -0-(CR a ,Rb)n7- wherein L is or wherein Re.Rf taken together with the carbon to which they are attached form a carbonyl group , r> 3 is 1 and Re is -0-(CR a ,Rb)n7-L wherein L is cycloalkyl , alkyl 7. A compound according to claim 1 of formula II wherein R c is H; mi is 0 or 1 ; y is 1-3; Ari and Ar2 are both 8. A compound according to claim 4 of the formula n wherein Ar-j and Ar2 are both 9. A compound according to claim 1 of the formula m wherein Ar-| and Ar2 are both 10. A compound according to claim 1 selected from the group consisting of or any enantiomer thereof, or a pharmaceutically acceptable salt thereof. 1 1. A compound selected from the group consisting of rfrO Cl Cl Cl Cl or any enantiomer thereof, or a pharmaceutically acceptable salt thereof. 12. A composition comprising a neurokinin antagonistic effective amount of a compound according to claim 1 and a pharmaceutically acceptable carrier material. 13. A method for inducing neurokinin antagonism which comprises administering a neurokinin antagonistic effective amount of a compound according to claim 1 to a mammal in need thereof. 14. A method for treating chronic airway diseases such as asthma and allergies; inflammatory diseases such as inflammatory bowel disease, psoriasis, fibrositos, osteoarthritis, and rheumatoid arthritis; migraine; central nervous system disorders such as depression, psychosis, dementia, and Alzheimer's disease; Down's syndrome; neuropathy; multiple sclerosis; ophthalmic disorders; conjunctivitis; auto immune disorders; graft rejection; systemic lupus erythematosus; Gl disorders such as Crohn's disease and ulcerative colitis; disorders of bladder function; circulatory disorders such as angina; Raynaud's disease; coughing and pain, which comprises administering a therapeutically effective amount of a compound according to claim 1.

Inventors: BLYTHIN DAVID J, CHEN XIAO, MCCORMICK KEVIN D, PIWINSKI JOHN J, SHIH NENG-YANG, SHUE HO-JANE, BLYTHIN, DAVID, J., CHEN, XIAO, MCCORMICK, KEVIN, D., PIWINSKI, JOHN, J., SHIH, NENG-YANG, SHUE, HO-JANE
Applicants: SCHERING CORP, SCHERING CORPORATION
Application year: 1996
Main classification: C07D401
IPC codes: A61K31, A61P1, A61P9, A61P11, A61P13, A61P15, A61P25, A61P27, A61P29, A61P37, A61P43, C07D241, C07D401, C07D403, C07D405, C07D409, C07D413, C07D417, C07D453, C07D471, C07D487