PRODRUGS OF MORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS

Abstract: Substituted heterocycles of general structural formula (I) are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis.

Description: TITLE OF THE INVENTION PRODRUGS OF MORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS BACKGROUND OF THE INVENTION Analgesia has historically been achieved in the central nervous system by opiates and analogs which are addictive, and peripherally by cyclooxygenase inhibitors that have gastric side effects. Substance P antagonists may induce analgesia both centrally and peripherally. In addition, substance P antagonists are inhibitory of neurogenic inflammation. The neuropeptide receptors for substance P (neurokinin-1 ; NK-1) are widely distributed throughout the mammalian nervous system (especially brain and spinal ganglia), the circulatory system and peripheral tissues (especially the duodenum and jejunum) and are involved in regulating a number of diverse biological processes. This includes sensory perception of olfaction, vision, audition and pain, movement control, gastric motility, vasodilation, salivation, and micturition (B. Pernow, Pharmacol. Rev.. 1983, 3£, 85-141). The NKl and NK2 receptor subtypes are implicated in synaptic transmission (Laneuville et al., Life Sci.. 42: 1295-1305 (1988)). The receptor for substance P is a member of the superfamily of G protein-coupled receptors. This superfamily is an extremely diverse group of receptors in terms of activating ligands and biological functions. In addition to the tachykinin receptors, this receptor superfamily includes the opsins, the adrenergic receptors, the muscarinic receptors, the dopamine receptors, the serotonin receptors, a thyroid-stimulating hormone receptor, a luteinizing hormone- choriogonadotropic hormone receptor, the product of the oncogene ras, the yeast mating factor receptors, a Dictvostelium cAMP receptor, and receptors for other hormones and neurotransmitters (see A.D. Hershey, et al.. J. Biol. Chem.. 1991, 226, 4366-4373). Substance P (also called "SP" herein) is a naturally occurring undecapeptide belonging to the tachykinin family of peptides, the latter being so-named because of their prompt contractile action on extravascular smooth muscle tissue. The tachykinins are distinguished by a conserved carboxyl-terminal sequence Phe-X-Gly-Leu-Met-NH2- In addition to SP the known mammalian tachykinins include neurokinin A and neurokinin B. The current nomenclature designates the receptors for SP, neurokinin A, and neurokinin B as NK-1 , NK-2, and NK-3, respectively. More specifically, substance P is a pharmacologically-active neuropeptide that is produced in mammals and possesses a characteristic amino acid sequence (Chang et al.. Nature New Biol. 232. 86 (1971); D.F. Veber et ah, U.S. Patent No. 4.680.283). Substance P is a pharmacologically-active neuropeptide that is produced in mammals and acts as a vasodilator, a depressant, stimulates salivation and produces increased capillary permeability. It is also capable of producing both analgesia and hyperalgesia in animals, depending on dose and pain responsiveness of the animal (see R.C.A. Frederickson et al., Science. 199. 1359 (1978); P. Oehme et al., Science. 208. 305 (1980)) and plays a role in sensory transmission and pain perception (T.M. Jessell, Advan. Biochem. Psychopharmacol. 28. 189 (1981)). For example, substance P is believed to be involved in the neurotransmission of pain sensations [Otsuka et al, "Role of Substance P as a Sensory Transmitter in Spinal Cord and Sympathetic Ganglia" in 1982 Substance P in the Nervous System, Ciba Foundation Symposium 91 , 13-34 (published by Pitman) and Otsuka and Yanagisawa, "Does Substance P Act as a Pain Transmitter?" TIPS. 8 506-510 (Dec. 1987)], specifically in the transmission of pain in migraine (see B.E.B. Sandberg et al, Journal of Medicinal Chemistry. 25, 1009 (1982); M. A. Moskowitz, Trends Pharmacol. Sci.. 13, 307-311 (1992)), and in arthritis (Levine, et aL Science. 226 547-549 (1984); M. Lotz, et aL, Science. 235, 893-895 (1987)). Tachykinins have also been implicated in gastrointestinal (GI) disorders and diseases of the GI tract, such as inflammatory bowel disease [see Mantyh et aL, Neuro cience. 25 (3), 817-37 (1988) and D. Regoli in "Trends in Cluster Headache" Ed. F. Sicuteri et al., Elsevier Scientific Publishers, Amsterdam, pp. 85-95 (1987)], and emesis ITrends Pharmacol. Sci.. 9. 334-341 (1988), F.D. Tatersall, et al., Eur. J. Pharmacol.. 250. R5-R6 (1993)]. It is also hypothesized that there is a neurogenic mechanism for arthritis in which substance P may play a role [Kidd et aL, "A Neurogenic Mechanism for Symmetric Arthritis" in The Lancet. 1 1 November 1989 and Gronblad et aL, "Neuropeptides in Synovium of Patients with Rheumatoid Arthritis and Osteoarthritis" in J. Rheumatol. L5(12) 1807-10 (1988)]. Therefore, substance P is believed to be involved in the inflammatory response in diseases such as rheumatoid arthritis and osteoarthritis [O'Byrne et aL, Arthritis and Rheumatism. 33 1023-8 (1990)]. Evidence for the usefulness of tachykinin receptor antagonists in pain, headache, especially migraine, Alzheimer's disease, multiple sclerosis, attenuation of morphine withdrawal, cardiovascular changes, oedema, such as oedema caused by thermal injury, chronic inflammatory diseases such as rheumatoid arthritis, asthma/bronchial hyperreactivity and other respiratory diseases including allergic rhinitis, inflammatory diseases of the gut including ulcerative colitis and Chrohn's disease, ocular injury and ocular inflammatory diseases, proliferative vitreoretinopathy, irritable bowel syndrome and disorders of bladder function including cystitis and bladder detruser hyperreflexia is reviewed in "Tachykinin Receptors and Tachykinin Receptor Antagonists," CA. Maggi, R. Patacchini, P. Rovero and A. Giachetti, J. Auton. Pharmacol. 13, 23-93 (1993); see also R. M. Snider, et aL, Chem. Ind.. 1 1. 792-794 (1991). Neurokinin-1 receptor antagonists alone or in combination with bradykinin receptor antagonists may also be useful in the prevention and treatment of inflammatory conditions in the lower urinary tract, especially cystitis [Giuliani, et al., J. Urology. 150. 1014-1017 (1993)]. Other disease areas where tachykinin antagonists are believed to be useful are allergic conditions [Hamelet et aL. Can. J. Pharmacol. PhvsioL. 66. 1361-7 (1988)], immunoregulation [Lotz, et aL, Science. 241 1218-21 (1988), Kimball, et aL, J. Immunol.. 141 (10) 3564-9 (1988); A. Perianin, et aL, Biochem. Biophvs. Res Commun. 161. 520 (1989)], post-operative pain and nausea [C. Bountra, et al., Eur. J. Pharmacol.. 249, R3-R4 (1993), F. D. Tattersall, et aL, Neuropharmacologv. 33, 259-260 (1994)], vasodilation, bronchospasm, reflex or neuronal control of the viscera [Mantyh et aL, PNAS. 85. 3235-9 (1988)] and, possibly by arresting or slowing β-amyloid- mediated neurodegenerative changes [Yankner et aL, Science. 250. 279- 82 (1990)] in senile dementia of the Alzheimer type, Alzheimer's disease and Downs Syndrome. Substance P may also play a role in demyelinating diseases such as multiple sclerosis and amyotrophic lateral sclerosis [J. Luber-Narod, et. aL, poster C.I.N.P. XVIIIth Congress, 28th June-2nd July, 1992], and in disorders of bladder function such as bladder detrusor hyper-reflexia [Lancet. 16th May 1992, 1239]. Antagonists selective for the neurokinin- 1 (NK-1) and/or the neurokinin-2 (NK-2) receptor may be useful in the treatment of asthmatic disease (Frossard et al., Life Sci.. 49, 1941-1953 (1991); Advenier, et al., Biochem. Biophys. Res. Comm.. 184(3). 1418-1424 (1992); P. Barnes, et al., Trends Pharmacol. Sci.. ϋ, 185-189 (1993)). Tachykinin antagonists may also be useful in the treatment of small cell carcinomas, in particular small cell lung cancer (SCLC) [Langdon et aL, Cancer Research. 52, 4554-7 (1992)]. It has furthermore been suggested that tachykinin receptor antagonists have utility in the following disorders: depression, dysthymic disorders, chronic obstructive airways disease, hypersensitivity disorders such as poison ivy, vasospastic diseases such as angina and Reynauld's disease, fibrosing and collagen diseases such as scleroderma and eosinophillic fascioliasis, reflex sympathetic dystrophy such as shoulder/hand syndrome, addiction disorders such as alcoholism, stress related somatic disorders, neuropathy, neuralgia, disorder related to immune enhancement or suppression such as systemic lupus erythmatosus CEPO Publication No. 0,436,334), ophthalmic diseases such as conjunctivitis, vernal conjunctivitis, and the like, and cutaneous diseases such as contact dermatitis, atopic dermatitis, urticaria, and other eczematoid dermatitis (ΕPO Publication No. 0,394,989). Substance P antagonists may be useful in mediating neurogenic mucus secretion in mammalian airways and hence provide treatment and symptomatic relief in diseases characterized by mucus secretion, in particular, cystic fibrosis [S. Ramnarine, et al., abstract presented at 1993 ALA/ATS Infl Conference, 16-19 May, 1993, published in Am. Rev, of Respiratory Pis.. May 1993]. In the recent past, some attempts have been made to provide peptide-like substances that are antagonists for the receptors of substance P and other tachykinin peptides in order to more effectively treat the various disorders and diseases mentioned above. For example Lowe. Drugs of the Future. 17 (12) 1 115-1121 (1992) and EPO Publication Nos. 0,347,802, 0,401 ,177 and 0,412,452 disclose various peptides as neurokinin A antagonists. Also, PCT Patent Publication WO 93/14113 discloses certain peptides as tachykinin antagonists. In addition, EPO Publication No. 0,336,230 discloses heptapeptides which are substance P antagonists useful in the treatment of asthma. Merck U.S. Patent No. 4,680,283 also discloses peptidal analogs of substance P. Certain inhibitors of tachykinins have been described in U.S. Patent No. 4,501,733, by replacing residues in substance P sequence by Trp residues. A further class of tachykinin receptor antagonists, comprising a monomeric or dimeric hexa- or heptapeptide unit in linear or cyclic form, is described in GB-A-2216529. The peptide-like nature of such substances make them too labile from a metabolic point of view to serve as practical therapeutic agents in the treatment of disease. The non-peptidic antagonists of the present invention, on the other hand, do not possess this drawback, as they are expected to be more stable from a metabolic point of view than the previously-discussed agents. It is known in the art that baclofen (β-(aminoethyl)-4- chlorobenzenepropanoic acid) in the central nervous system effectively blocks the excitatory activity of substance P, and the excitatory responses to other compounds such as acetylcholine and glutamate are inhibited as well. Pfizer WIPO patent applications (PCT Publication Nos. WO 90/05525. WO 90/05729. WO 91/18899. WO 92/12151 and WO 92/12152) and publications (Science. 251. 435-437 (1991); Science. 251. 437-439 (1991 ); J. Med. Chem.. 35, 2591-2600 (1992)) disclose 2- arylmethyl-3 -substituted amino-quinuclidine derivatives which are disclosed as being useful as substance P antagonists for treating gastrointestinal disorders, central nervous system disorders, inflammatory diseases and pain or migraine. A Glaxo European patent application (EPO Publication No. 0.360.390) discloses various spirolactam-substituted amino acids and peptides which are antagonists or agonists of substance P. A Pfizer WIPO patent application (PCT Publication No. WO 92/06079) discloses fused-ring analogs of nitrogen- containing nonaromatic heterocycles as useful for the treatment of diseases mediated by an excess of substance P. A Pfizer WIPO patent application (PCT Publication No. WO 92/15585 discloses 1- azabicyclo[3.2.2]nonan-3-amine derivatives as substance P antagonists. A Pfizer WIPO patent application (PCT Publication No. WO 93/10073) discloses ethylenediamine derivatives as substance P antagonists. PCT Publication No. WO 93/01 169 discloses certain aromatic compounds as tachykinin receptor antagonists. A Sanofi publication (Life Sci.. 50. PL101-PL106 (1992)) discloses a 4-phenyl piperidine derivative as an antagonist of the neurokinin A (NK2) receptor. Howson et al. (Biorg. & Med. Chem. Lett.. 2 (6), 559-564 (1992)) disclose certain 3-amino and 3-oxy quinuchdine compounds and their binding to substance P receptors. EPO Publication 0.499.313 discloses certain 3-oxy and 3-thio azabicyclic compounds as tachykinin antagonists. U.S. Patent No. 3.506.673 discloses certain 3-hydroxy quinuchdine compounds as central nervous system stimulants. A Pfizer EPO Patent application (EPO Publication 0.436.334) discloses certain 3- aminopiperidine compounds as substance P antagonists. U.S. Patent No. 5.064.838 discloses certain 1 ,4-disubstituted piperidinyl compounds as analgesics. PCT Publication No. WO 92/12128 discloses certain piperidine and pyrrolidine compounds as analgesics. Peyronel, et al. (Biorg & Med. Chem. Lett.. 2 (1), 37-40 (1992)) disclose a fused ring pyrrolidine compound as a substance P antagonist. EPO Publication No. 0.360.390 discloses certain spirolactam derivatives as substance P antagonists. U.S. Patent No. 4.804.661 discloses certain piperazine compounds as analgesics. U.S. Patent No. 4.943.578 discloses certain piperazine compounds useful in the treatment of pain. PCT Publication No. WO 92/01679 discloses certain 1 ,4-disubstituted piperazines useful in the treatment of mental disorders in which a dopaminergic deficit is implicated. PCT Publication No. WO 94/00440 and EPO Publication No. 0.577.394 disclose certain morpholine and thiomorpholine substance P antagonists, some of which are the parent compounds to the instant prodrugs. Prodrugs are entities structurally related to a biologically active substance (the "parent drug") which, after administration, release the parent drug in vivo as the result of some metabolic process, such as enzymatic or chemical hydrolysis of a carboxylic, phosphoric or sulfate ester or reduction or oxidation of a susceptible functionality (see, for example, discussions by (1) A. A. Sinkula and S.H. Yalkowsky, J. Pharm. Sci. 64. 181 (1975): (2) L.A. Svensson. Phar Weekbl. 122. 245-250 (1987); (3) L.P. Balant, E. Doelker and P. Buri Eur. J. Drug Metab. and Pharmacokinetics. 15. 143-153 (1990); (4) N. Bodor, Drugs of the Future. 6. 165-182 (1981); (5) Design of Biopharmaceutical Properties through Prodrugs and Analogs. , E.B. Roche, Ed., American Pharmaceutical Association Academy of Pharmaceutical Sciences, Washington, DC, (1977); (6) H. Bundgaard Advanced Drug Delivery Reviews. 3, 39-65 (1989)). The advantage of a prodrug may lie in its physical properties, such as enhanced water solubility for parenteral administration compared to the parent drug, or it may enhance absorption from the digestive tract, or it may enhance drug stability for long-term storage. In general, a prodrug possesses less biological activity than its parent drug. SUMMARY OF THE INVENTION This invention is concerned with novel compounds represented by structural formula I: wherein R2, R3, R6, R7, R8, R1 1, Rl2, Rl3, A, B, p, Y and Z are hereinafter defined. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are tachykinin receptor antagonists and are useful in the treatment of inflammatory diseases, pain or migraine, asthma, and emesis. DETAILED DESCRIPTION OF THE INVENTION The novel compounds of this invention are represented by structural formula I: or a pharmaceutically acceptable salt thereof, wherein: R2 and R3 are independently selected from the group consisting of: (1) hydrogen, (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl -3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR9R 10, wherein R9 and R 10 are independently selected from: (i) hydrogen, (ii) Cl-6 alkyl, (iii) hydroxy-Cl-6 alkyl, and (iv) phenyl, (i) -NR9COR 10, wherein R9 and R 10 are as defined above, (j) -NR9C02R 10, wherein R9 and R 10 are as defined above, (k) -CONR9R10, wherein R9 and RlO are as defined above, (1) -COR9, wherein R9 is as defined above, and (m) -C02R9, wherein R9 is as defined above; (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR9R 10 wherein R9 and R 10 are as defined above, (i) -COR9 wherein R9 is as defined above, (j) -C02R9, wherein R9 is as defined above; (4) C2-6 alkynyl; (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) Cl-6 alkoxy, (c) Cl-6 alkyl, (d) C2-5 alkenyl, (e) halo, (f) -CN, (g) -N02, (h) -CF3, (i) -(CH2)m-NR9RlO, wherein m, R9 and RlO are as defined above, (j) -NR9COR 10, wherein R9 and R 1 are as defined above, (k) -NR9C02R 1 °, wherein R9 and R 10 are as defined above, (1) -CONR9R 10, wherein R9 and R 10 are as defined above, (m) -C02NR9R 10, wherein R9 and R 10 are as defined above, (n) -COR9, wherein R9 is as defined above; (o) -C02R , wherein R9 is as defined above; and, alternatively, the groups R2 and R3 are joined together to form a carbocyclic ring selected from the group consisting of: (a) cyclopentyl, (b) cyclohexyl, (c) phenyl, and wherein the carbocyclic ring is unsubstituted or substituted with one or more substituents selected from: (i) Cl-6alkyl, (ii) Cl-6alkoxy, (iii) -NR9R 10, wherein R9 and R 10 are as defined above, (iv) halo, and v) trifluoromethyl; and, alternatively, the groups R2 and R3 are joined together to form a heterocyclic ring selected from the group consisting of: (a) pyrrolidinyl, (b) piperidinyl, (c) pyrrolyl, (d) pyridinyl, (e) imidazolyl, (f) furanyl, (g) oxazolyl, (h) thienyl, and (i) thiazolyl, and wherein the heterocyclic ring is unsubstituted or substituted with one or more substituent(s) selected from: (i) Cl-6alkyl, (ii) oxo, (iii) Cl-6alkoxy, (iv) -NR9R 10, wherein R9 and R 10 are as defined above, (v) halo, and (vi) trifluoromethyl; R6, R7 and R$ are independently selected from the group consisting of: (1) hydrogen; (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR9R 10, wherein R9 and R 10 are as defined above, (i) -NR9COR10, wherein R9 and RlO are as defined above, (j) -NR9C02R10, wherein R9 and RlO are as defined above, (k) -CONR9R10, wherein R9 and RlO are as defined above, (1) -C0R9, wherein R9 is as defined above, and (m) -C02R9, wherein R9 is as defined above; (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (6) halo, (7) -CN, (8) -CF3, (9) -N02, (10 -SR14, wherein Rl4 is hydrogen or Ci-5alkyl, (11 -SOR14, wherein R 14 is as defined above, (12 -S02R14, wherein Rl4 is as defined above, (13 NR9COR10, wherein R9 and RlO are as defined above, (14 CONR9COR10, wherein R9 and RlO are as defined above, (15 NR9R10, wherein R9 and RlO are as defined above, (16 NR9CO2R10, wherein R9 and RlO are as defined above, (17 hydroxy, (18 Cl-6alkoxy, (19 COR9, wherein R9 is as defined above, (20 C02R9, wherein R9 is as defined above, (21 2-pyridyl, (22 3-pyridyl, (23 4-ρyridyl, (24 5-tetrazolyl, (25 2-oxazolyl, and (26 2-thiazolyl; Rl 1 , Rl2 and Rl3 are independently selected from the definitions of R6, R7 and R8, or -OX; A is selected from the group consisting of: (1) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Ci-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, wherein halo is fluoro, chJoro, bromo or iodo, (h) -NR9R10, wherein R9 and RlO are as defined above, (i) -NR9COR 10, wherein R9 and R 10 are as defined above, (j) -NR9C02Rl°, wherein R9 and RlO are as defined above, (k) -CONR9R 10, wherein R9 and R 10 are as defined above, (1) -COR9, wherein R9 is as defined above, and (m) -C02R9, wherein R9 is as defined above; (2) (3) C2-6 alkynyl; B is a heterocycle, wherein the heterocycle is selected from the group consisting of: 10 H . N-N N-N H X 15 20 X and wherein the heterocycle is substituted in addition to -X with one or more substituent(s) selected from: (i) hydrogen (ii) Cl-6 alkyl, unsubstituted or substituted with halo, -CF3, -OCH3, or phenyl, (iii) Cl-6 alkoxy, (iv) oxo, (v) hydroxy, (vi) thioxo, (vii) -SR9, wherein R9 is as defined above, (viii) halo, (ix) cyano, (x) phenyl, (xi) trifluoromethyl, (xii) -(CH2)m-NR9RlO, wherein m is 0, 1 or 2, and R9 and RlO are as defined above, (xiii) -NR9COR10, wherein R9 and RlO are as defined above, (xiv) -CONR9R10, wherein R9 and RlO are as defined above, (xv) -C02R9, wherein R9 is as defined above, and (xvi) -(CH2)m-OR9, wherein m and R9 are as defined above; p is 0 or 1; X is selected from: (a) -PO(OH)0" • M+, wherein M+ is a pharmaceutically acceptable monovalent counterion, (b) -PO(0")2 • 2M+, (c) -PO(0")2 • D +, wherein D2+ is a pharmaceutically acceptable divalent counterion, (d) -CH(R4)-PO(OH)0- • M+, wherein R4 is hydrogen or C1-3 alkyl, (e) -CH(R4)-PO(0-)2 • 2M+, (f) -CH(R4)-PO(0->2 • D2+, (i) -CO-CH2CH2-CO2- • M+, (j) -CH(CH3)-0-CO-R5, wherein R5 is selected from the group consisting of: (k) hydrogen, with the proviso that if p is 0 and none of Rl 1 , Rl2 or Rl3 are -OX, then X is other than hydrogen; Y is selected from the group consisting of: (1) a single bond, (2) -0-, (3) -S-, (4) -CO-, (5) -CH2-, (6) -CHRl5-, and (7) -CR 15R 16-, wherein R 15 and R 16 are independently selected from the group consisting of: (a) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (i) hydroxy, (ii) oxo, (iii) Cl-6 alkoxy, (iv) phenyl-Cl-3 alkoxy, (v) phenyl, (vi) -CN, (vii) halo, (viii) -NR9R10, wherein R9 and RlO are as defined above, (ix) -NR9C0R 10, wherein R9 and R 10 are as defined above, (x) -NR9C02R 10, wherein R9 and R 10 are as defmed above, (xi) -CONR9R 10, wherein R9 and RlO are as defined above, (xii) -COR9, wherein R9 is as defined above, and (xiii) -C02R9, wherein R9 is as defined above; (b) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (i) hydroxy, (ii) Cl-6 alkoxy, (iii) Cl-6 alkyl, (iv) C2-5 alkenyl, (v) halo, (vi) -CN, (vii) -N02, (viii) -CF3, (ix) -(CH2)m-NR9R 10, wherein m, R9 and R 10 are as defined above, (x) -NR9COR10, wherein R9 and RlO are as defined above, (xi) -NR9C02R 10, wherein R9 and R 10 are as defined above, (xii) -CONR9R 10, wherein R9 and R 10 are as defined above, (xiii) -CO2NR9R10, wherein R9 and RlO are as defined above, (xiv) -COR9, wherein R9 is as defined above, and (xv) -C02R9, wherein R9 is as defined above; Z is selected from: (1) hydrogen, (2) Cl -6 alkyl, and (3) hydroxy, with the proviso that if Y is -0-, Z is other than hydroxy, or if Y is -CHR15-, then Z and Rl5 are optionally joined together to form a double bond. The instant compounds are prodrugs of their parent compounds. A principal advantage of the instant compounds is that they possess enhanced solubility in aqueous solutions relative to their parent compounds. In addition, the prodrugs generally have diminished activity at antagonizing tachykinin receptors than their parent compounds. Thus, the activity exhibited upon administration of the prodrug is principally due to the presence of the parent compound that results from cleavage of the prodrug. The term "prodrug" refers to compounds which are drug precursors which, following administration and absorption, release the drug in vivo via some metabolic process. Prodrugs are entities structurally related to an biologically active substance (the "parent drug") which, after administration, release the parent drug in vivo as the result of some metabolic process, such as enzymatic or chemical hydrolysis of a carboxylic, phosphoric or sulfate ester or reduction or oxidation of a susceptible functionality (see, for example, discussions by (1) A.A. Sinkula and S.H. Yalkowsky, Pharm. Sci. 64. 181 (1975); (2) L.A. Svensson. Pharm Weekbl. 122. 245-250 (1987); (3) L.P. Balant, E. Doelker and P. Buri Eur. J. Drug Metab. and Pharmacokinetics. 15. 143-153 (1990); (4) N. Bodor, Drugs of the Future. 6. 165-182 (1981); (5) Design of Biopharmaceutical Properties through Prodrugs and Analogs. , E.B. Roche, Ed., American Pharmaceutical Association Academy of Pharmaceutical Sciences, Washington, DC, (1977); (6) H. Bundgaard Advanced Drug Delivery Reviews. 3, 39-65 (1989)). The advantage of a prodrug may lie in its physical properties, such as enhanced water solubility for parenteral administration compared to the parent drug, or it may enhance absorption from the digestive tract, or it may enhance drug stability for long-term storage. In general, a prodrug possesses less biological activity than its parent drug. A prodrug may also improve overall drug efficacy, for example, through the reduction of toxicity and unwanted effects of a drug by controlling its absorption, blood levels, metabolic distribution and cellular uptake. The term "parent compound" or "parent drug" refers to the biologically active entity that is released via enzymatic action of a metabolic or a catabolic process, or via a chemical process following administration of the prodrug. The parent compound may also be the starting material for the preparation of its corresponding prodrug. While all of the usual routes of administration are useful with the present compounds, the preferred routes of administration are oral and intravenous. After gastrointestinal absorption or intravenous administration, the present compounds are hydrolyzed or otherwise cleaved in vivo to the corresponding parent compounds of formula I, wherein X is hydrogen or X is absent, or a salt thereof. Since the parent compounds may be relatively insoluble in aqueous solutions, the instant prodrugs provide a distinct advantage by virtue of their relatively enhanced aqueous solubility. The compounds of the present invention have asymmetric centers and this invention includes all of the optical isomers and mixtures thereof. In addition compounds with carbon-carbon double bonds may occur in Z- and E- forms with all isomeric forms of the compounds being included in the present invention. When any variable (e.g., alkyl, aryl, R6, R7, R8, R9, RlO, Rl 1, Rl2, Rl3, etc.) occurs more than one time in any variable or in Formula I, its definition on each ocurrence is independent of its definition at every other occurrence. As used herein, the term "alkyl" includes those alkyl groups of a designated number of carbon atoms of either a straight, branched, or cyclic configuration. Examples of "alkyl" include methyl, ethyl, propyl, isopropyl, butyl, iso- sec- and tert-butyl, pentyl, hexyl, heptyl, 3-ethylbutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, norbornyl, and the like. "Alkoxy" represents an alkyl group of indicated number of carbon atcms attached through an oxygen bridge, such as methoxy, ethoxy, propoxy, butoxy and pentoxy. "Alkenyl" is intended to include hydrocarbon chains of a specified number of carbon atoms of either a straight- or branched- configuration and at least one unsaturation, which may occur at any point along the chain, such as ethenyl, propenyl, butenyl, pentenyl, dimethylpentyl, and the like, and includes E and Z forms, where applicable. "Halogen" or "halo", as used herein, means fluoro, chloro, bromo and iodo. The compounds of the present invention are capable of forming salts with various inorganic and organic acids and bases and such salts are also within the scope of this invention. Examples of such acid addition salts (which are negative counterions defined herein as "M-") include acetate, adipate, benzoate, benzenesulfonate, bisulfate, butyrate, camphorate, camphorsulfonate, citrate, ethanesulfonate, fumarate, hemisulfate, 2-hydroxyethylsulfonate, heptanoate, hexanoate, hydrochloride, hydrobromide, hydroiodide, lactate, malate, maleate, methanesulfonate, 2-naphthalenesulfonate, oxalate, pamoate, persulfate, picrate, pivalate, propionate, salicylate, stearate, succinate, sulfate, tartrate, tosylate (p-toluenesulfonate), and undecanoate. Base salts (which are pharmaceutically acceptable monovalent cations defined herein as "M+ or K + " or pharmaceutically acceptable divalent cations defined herein as "D2+", if appropriate) include ammonium salts, alkali metal salts such as sodium, lithium and potassium salts, alkaline earth metal salts such as aluminum, calcium and magnesium salts, salts with organic bases such as dicyclohexylamine salts, N-methyl-D-glucamine, and salts with amino acids such as arginine, lysine, ornithine, and so forth. If M + is a monovalent cation, it is recognized that if the definition 2M+ is present, each of M + may be the same or different. In addition, it is similarly recognized that if the definition 2M+ is present, a divalent cation D2+ may instead be present. Also, the basic nitrogen- containing groups may be quaternized with such agents as: lower alkyl halides, such as methyl, ethyl, propyl, and butyl chloride, bromides and iodides; dialkyl sulfates like dimethyl, diethyl, dibutyl; diamyl sulfates; long chain halides such as decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides; aralkyl halides like benzyl bromide and others. The non-toxic physiologically acceptable salts are preferred, although other salts are also useful, such as in isolating or purifying the product. The salts may be formed by conventional means, such as by reacting the free base form of the product with one or more equivalents of the appropriate acid in a solvent or medium in which the salt is insoluble, or in a solvent such as water which is removed in vacuo or by freeze drying or by exchanging the anions of an existing salt for another anion on a suitable ion exchange resin. In the compounds of formula I it is preferred that: R2 and R3 are independently selected from the group consisting of: (1) hydrogen, (2) Cl-6 alkyl, (3) C2-6 alkenyl, and (4) phenyl; R6, R7 and R8 are independently selected from the group consisting of: 30 p is O; X is selected from: (a) -PO(OH)0" • M + , wherein M + is a pharmaceutically acceptable monovalent counterion, (b) -PO(0")2 • 2M+, (c) -PO(0")2 • D2+, wherein D2+ is a pharmaceutically acceptable divalent counterion, (d) -CH(R 4 )-PO(OH)0- • M+, wherein R 4 is hydrogen or methyl, (e) -CH(R 4 )-PO(0-)2 • 2M+, wherein R 4 is hydrogen or methyl, (f) -CH(R )-PO(0-)2 • D +, wherein R 4 is hydrogen or methyl, (i) -CO-CH2CH2-CO2- • M+, (j) -CH(CH3)-0-CO-R5, wherein R5 is selected from the group consisting of: Y is -0-; Z is hydrogen or Cι_4 alkyl. In the compounds of the present invention a preferred embodiment includes those compounds wherein Z is Cι_4 alkyl. An especially preferred embodiment of the compounds of formula I includes those compounds wherein Z is -CH3. These compounds bearing a substituent on the alpha-carbon atom exibit advantageous pharmacological properties, in particular, enhanced duration of action in models of extravasation, presumably due to biological stability and resistance to enzymatic degradation. In the compounds of the present invention if p is 1 , it is preferred that X is hydrogen or is absent. In the compounds of the present invention a particularly preferred embodiment is that in which A is -CH2- or -CH(CH3)-. A particularly preferred embodiment of the compounds of the present invention includes the prodrugs of compounds of formula I wherein -A-B is a (l ,2,4-triazolo)methyl or a (5-oxo- 1 ,2,4- triazolo)methyl group. Another particularly preferred embodiment of the compounds of the present invention includes the prodrugs of compounds of formula I wherein -A-B is a (l,3-imidazolo)methyl or a (5-oxo-l,3- imidazolo)methyl group. An additional particularly preferred embodiment of the compounds of the present invention includes those compounds of formula I wherein -A-B is a (l ,2,4-triazolo)methyl or a (5-oxo-l,2,4- triazolo)methyl group bearing a phosphoryl group attached to the heterocycle. Yet another particularly preferred embodiment of the compounds of the present invention includes those compounds of formula I wherein -A-B is a (l ,3-imidazolo)methyl or a (1,3- imidazolo)methyl group bearing a phosphoryl group attached to the heterocycle. A preferred embodiment of the compounds of the present invention includes the compounds of formula I wherein X is selected from: (a) -PO(0")2 • 2M+, wherein M+ is a pharmaceutically acceptable monovalent counterion, (b) -P0(0")2 • D2+, wherein D2+ is a pharmaceutically acceptable divalent counterion, (c) -CH(CH3)-0-CO-CH2CH2-NH3+. M", and (d) -CH(CH3)-0-CO-CH2CH2-NH2+-(CH2CH2-OH) • M-. In the compounds of the present invention a particularly preferred embodiment is that in which -A-B is selected from the following group of substituents: Specific compounds within the scope of the present invention include the prodrugs of the following parent compounds: 1 ) (+/-)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3-phenyl- morpholine; 2) (2R,S)-(3 ,5-bis(trifluoromethyl)benzy loxy )-(3R)-pheny 1-(6R)- methyl-morpholine; 3) (2R,S)-(3,5-bis(trifluoromethyl)benzyloxy)-(3S)-phenyl-(6R)- methyl-morpholine; 4) (+/-)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3-phenyl-4- methylcarboxamido-mo holine; 5) (+/-)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3-phenyl-4-methoxy- carbonylmethyl-moφholine; 6) 2-(2-(3,5-bis(trifluoromethyl)phenyl)ethenyl)-3-phenyl-5-oxo- moφholine; 7) 3-phenyl-2-(2-(3,5-bis(trifluoromethyl)phenyl)-ethyl)- moφholine; 8) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(S)- methyl-moφholine; 9) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(S)- methyl-moφholine; 10) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(S)- methyl-moφholine; 11 ) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(S)- methyl-moφholine; 12) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(R)- methyl-moφholine; 13) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)- methyl-moφholine; 14) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(R)- methyl-moφholine; 15) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)- methyl-moφholine; 16 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl- moφholine; 17 4-(3-(l,2,4-triazolo)methyl)-2-(S)-(3,5-bis(trifluoro- methyl)benzyloxy)-3-(S)-phenyl-moφholine; 18 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-2-(S)-(3,5-bis- (trifluoromethyl)benzyloxy)-3-(S)-phenyl-moφholine; 19 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(R)- methyl-moφholine; 20 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(R)- methyl-moφholine; 21 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(R)- methyl-moφholine; 22 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(R)- methyl-moφholine; 23 2-(R)-(3,5-bis(trifluoromethyl)-benzyloxy)-3-(S)-phenyl-5-(S)- methyl-moφholine; 24 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(S)- methyl-moφholine; 25 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)- methyl-moφholine; 26 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)- phenyl-moφholine; 27 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)- phenyl-moφholine; 28 2-(S) -(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)- pheny 1-moφholine ; 29 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)- phenyl-moφholine; 30 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-6-(R)-methyl-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 31 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-6-(R)-methyl-4-(3-(5- oxo-lH,4H-l,2,4-triazolo)methyl)-3-(S)-phenyl-moφholine; 32 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl- moφholine; 4-(3-(l,2,4-triazolo)methyl)-2-(S)-(3,5-bis(trifluoro- methyl)benzyloxy)-3-(R)-phenyl-moφholine; 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-2-(S)-(3,5-bis- (trifluoromethyl)benzyloxy)-3-(R)-phenyl-moφholine; 4-(2-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoro-methyl)- benzyloxy)-3-(R)-phenyl-moφholine; 4-(4-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(R)-phenyl-moφholine; 4-(aminocarbonylmethyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(R)-phenyl-moφholine; 4-(2-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-moφholine; 4-(4-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-moφholine; 4-(2-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-6-(R)-methyl-moφholine; 4-(4-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-6(R)-methyl-moφholine; 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-((6-hydroxy)-hexyl)- 3-(R)-phenyl-moφholine; 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(5-(methylamino- carbonyl)pentyl)-3-(R)-phenyl-moφholine; 4-(3-(l,2,4-triazolo)methyl)-2-(3,5-dimethylbenzyloxy)-3- phenylmoφholine; 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-2-(3,5-dimethyl)- benzyloxy)-3-phenyl-moφholine; 4-(3-(l,2,4-triazolo)methyl)-2-(3,5-di(tert-butyl)- benzyloxy)-3-phenylmoφholine; 4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)-2-(3,5-di(tert-butyl)- benzyloxy)-3-phenyl-moφholine; 4-(3-(l ,2,4-triazolo)methyl)-2-(3-(tert-butyl)-5-methyl- benzyloxy)-3-phenyl-moφholine; 4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)-2-(3-(tert-butyl)-5- methylbenzyloxy)-3-phenyl-moφholine; 50 4-(3-(l,2,4-triazolo)methyl)-2-(3-(trifluoro-methyl)-5- methyl-benzyloxy)-3-phenyl-moφholine; 51 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-2-(3-(trifluoro- methyl)-5-methylbenzyloxy)-3-phenyl-moφholine; 52 4-(3-(l,2,4-triazolo)methyl)-2-(3-(tert-butyl)-5-(trifluoro- methyl)benzyloxy)-3-phenyl-moφholine; 53 4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-2-(3-(tert-butyl)-5- (trifluoromethyl)benzyloxy)-3-phenyl-moφholine; 54 4-(2-(imidazolo)methyl)-2-(3,5-dimethyl-benzyloxy)-3-ρhenyl- moφholine; 55 4-(4-(imidazolo)methyl)-2-(3,5-dimethyl-benzyloxy)-3-phenyl- moφholine; 56 4-(2-(imidazolo)methyl)-2-(3,5-di(tert-butyl)-benzyloxy)-3- phenyl-moφholine; 57 4-(4-(imidazolo)methyl)-2-(3,5-di(tert-butyl)-benzyloxy)-3- pheny 1-moφholine ; 58 4-(2-(imidazolo)methyl)-2-(3-(tert-butyl)-5-methylbenzyloxy)-3- pheny 1-moφholine ; 59 4-(4-(imidazolo)methyl)-2-(3-(tert-butyl)-5-methylbenzyloxy)-3- pheny 1-moφholine ; 60 4-(2-(imidazolo)methyl)-2-(3-(trifluoro-methyl)-5-methyl- benzyloxy)-3-phenyl-moφholine; 61 4-(4-(imidazolo)methyl)-2-(3-(trifluoro-methyl)-5-methyl- benzyloxy)-3-phenyl-moφholine; 62 4-(2-(imidazolo)methyl)-2-(3-(tert-butyl)-5-(trifluoromethyl)- benzyloxy)-3-phenyl-moφholine; 63 2-(S)-(3,5-dichlorobenzyloxy)-3-(S)-phenyl-moφholine; 64 2-(S)-(3,5-dichlorobenzyloxy)-4-(3-(5-oxo-lH,4H-l,2,4- triazolo)methyl)-3-(S)-phenylmoφholine; 65 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(methoxycarbonyl- methyl)-3-(S)-phenyl-moφholine; 66 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(carboxymethyl)-3- (S)-phenyl-moφholine; 67 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-((2-aminoethyl)- aminocarbonylmethyl)-3-(S)-phenyl-moφholine; 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-((3-aminopropyl)- amino carbonylmethyl)-3-(S)-phenylmoφholine; 4-benzyl-5-(S),6-(R)-dimethyl-3-(S)-phenylmoφholinone and 4- benzyl-5-(R),6-(S)-dimethyl-3-(S)-phenyl-moφholinone; 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-[5-(S),6-(R) or 5- (R),6-(S)-dimethyl]-3-(S)-phenyl-moφholinone; 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-[5-(R),6-(S) or 5- (S),6-(R)-dimethyl]-3-(S)-phenyl-moφholinone; 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(l ,2,4- triazolo)methyl)-[5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3-(S)- phenyl-moφholinone; 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(5-oxo-lH,4H- 1 ,2,4-triazolo) methyl)-[5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3- (S)-phenyl-moφholinone; 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(l,2,4- triazolo)methyl)-[5-(R),6-(S) or 5-(S),6-(R)-dimethyl]-3-(S)- phenyl-moφholinone; 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(5-oxo-lH,4H- l,2,4-triazolo)methyl)-[5-(R),6-(S) or 5-(S),6-(R)-dimethyl]-3- (S)-phenyl-moφholinone; 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(2-(l-(4-benzyl)- piperidino)ethyl)-3-(S)-phenyl-moφholine; 3-(S)-(4-fluorophenyl)-4-benzyl-2-moφholinone; 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluoro- pheny l)-4-benzyl-moφholine ; 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluorophenyl) moφholine; 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluoro- phenyl)-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl-moφholine; 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-((3-pyridyl)methyl carbonyl)-3-(R)-phenyl-moφholine; 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(methoxycarbonyl- pentyl)-3-(R)-phenyl-moφholine; 83 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(carboxypentyl)-3- (R)-phenyl-moφholine; 84 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(methylamino- carbonylpentyl)-6-oxo-hexyl)-3-(R)-ρhenyl-moφholine; 85 2-(R)-(3,5-bis(trifluoromethyl)benzoyloxy)-3-(S)-phenyl-4- benzyl-moφholine; 86 2-(R)-(l-(3,5-bis(trifluoromethyl)phenyl)ethenyloxy)-3-(S)- phenyl-4-benzyl-moφholine; 87 2-(R)-(l-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 88 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 89 2-(R)-(l-(S)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 90 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 91 2-(R)-(3,5-bis(trifluoromethyl)benzoyloxy)-3-(S)-(4-fluoro)- phenyl-4-benzyl-moφholine; 92 2-(R)-(l-(3,5-bis(trifluoromethyl)phenyl)ethenyloxy)-3-(S)-(4- fluoro)phenyl-4-benzyl-moφholine; 93 2-(R)-(l-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 94 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 95 2-(R)-(l-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- moφholine; 96 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methy 1- moφholine; 97) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (1 ,2,4-triazolo)methyl-moφholine; 98 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl-moφholine; 99) 2-(R)-(l -(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-moφholine; 100) 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 101) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-moφholine; 102) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)- moφholine; 103) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 104) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo-lH,4H-l ,2,4-triazolo)methyl)-moφholine; 105) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 106) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 107) 2-(R)-( 1 -(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 108) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3 -(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 109) 2-(R)-(l -(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 110) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)-moφholine; 111) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 112) 2-(R)-(l -(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 113) 2-(R)-(l-(R)-(3-(isopropoxy)-5-trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-moφholine; 114) 2-(R)-(l-(R)-(3-(isopropoxy)-5-trifluoromethyl)phenyl)ethoxy)- 3-(S)-pheny l-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 115) 2-(R)-(l -(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 116) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 117) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 118) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)-moφholine; 119) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 120) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 121) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 122) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 123) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-moφholine; 124) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 125) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 126) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)-moφholine; 127) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 128) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(3 -(5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφholine; 129) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-ρhenyl-moφholine; 130) 2-(R)-(l -(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 131 ) 2-(R)-(l -(R)-(3,5-bis(trifluoromethyl)-4-chloro)phenyl)ethoxy)- 3-(S)-phenyl-moφholine; 132) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-chloro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 133) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 134) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 135) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 136) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 137) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-phenyl-moφholine; 138) 2-(R)-(l -(R)-( 1 -(naphthyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H-1 ,2,4-triazolo)methylmoφholine; 139) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 140) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφho line; 141) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 142) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφholine; 143) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 144) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφholine; 145) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 146 2-(R)-(l -(R)-(l -(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφholine; 147 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-moφholine; 148 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 149 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-hydroxy)- phenyl-moφholine; 150 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-hydroxy)- phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 151 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl- moφholine; 152 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-moφholine; 153 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-moφholine; 154 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 155 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 156 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 157 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 158 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 159 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- (5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 160 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3 -(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 161 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 162 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3 -(5-oxo- 1H,4H-1, 2,4-triazolo)methyl)- moφholine; 163 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 164 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyϊ-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 165 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 166 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 167 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 168 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 169 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-imidazolo)methyl-moφholine; 170 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 171 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 172 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 173 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-imidazolo)methyl-moφholine; 174 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 175 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-ρhenyl-4-(5- tetrazolo)methyl-moφholine; 176 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 177 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(5-tetrazolo)methyl-moφholine; 178) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 179) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- oxo-5H-pyrrol-4-yl)methyl-moφholine; 180) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 181) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 182) 2-(R)-(l -(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 183) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl- moφholine; 184) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-moφholine; 185) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-moφholine; 186) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-moφholine; 187) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- ( 1 ,2,4-triazolo)methy 1-moφholine; 188) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 189) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 190) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 191) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- (5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφholine; 192) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)- moφholine; 193) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)-moφholine; 194) 2-(R)-(l -(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(3 -(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholin ; 195) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-ρhenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 196) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 197) 2-(R)-(l -(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 198) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-(2-oxo-l ,3-imidazolo)methyl)-moφholine; 199) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- imidazolo)methyl)-moφholine; 200) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl)-moφholine; 201) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-imidazolo)methyl)-moφholine; 202) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(2-imidazolo)methyl)-moφholine; 203) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- imidazolo)methyl)-moφholine; 204) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 205) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-imidazolo)methyl-moφholine; 206) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 207) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 208) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 209) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(5-tetrazolo)methyl-moφholine; 210 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 211 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- oxo-5H-pyrrol-4-yl)methyl-moφholine; 212 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 213 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 214 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 215 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-moφholine; 216 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 217 2-(R)-(l-(R)-(3-methyl)ρhenylethoxy)-3-(S)-phenyl-moφholine; 218 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 219 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl)-moφholine; 220 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4- triazolo)methyl)-moφholine; 221 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl)-moφholine; 222 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl)-moφholine; 223 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo- 1 ,2,4- triazolo)methyl)-moφholine; 224 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- l,2,4-triazolo)methyl)-moφholine; 225 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- l,2,4-triazolo)methyl)-moφholine; 226 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-l,2,4-triazolo)methyl)-moφholine; 227 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo-l,3- imidazolo)methyl)-moφholine; 228 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 229 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 230 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 231 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 232 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 233 2-(R)-(l -(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 234 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine; 235 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 236 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 237 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)metbyl-moφholine; 238 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 239 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholine; 240 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 241 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 242 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-moφholine; 243 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- yl)methyl-moφholine; 244 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 245) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 246) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 247) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-moφholine; 248) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 249) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-moφholine; 250) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 251) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(3-(l ,2,4- triazolo)methyl-moφholine; 252) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 253) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 254) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl-moφholine; 255) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo-lH,4H- 1 ,2,4-triazolo)methyl-moφholine; 256) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl-moφholine; 257) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 258) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 259) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo-l ,3- imidazolo)methyl)-moφholine; 260) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 261) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 262) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 263 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 264 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 265 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 266 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine; 267 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 268 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 269 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 270 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 271 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholine; 272 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 273 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 274 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-moφholine; 275 2 -(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- yl)methyl-moφholine; 276 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 277 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 278 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 279 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-moφholine; 280 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 281 ) 2-(R)-( 1 -(R)-(3-chloro)phenylethoxy)-3-(S)-pheny 1-moφholine; 282) 2-(R)-(l -(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 283) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(3-(l ,2,4- tπazolo)methyl)-moφholine; 284) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4- triazolo)methyl)-moφholine; 285) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(3-(l ,2,4- triazolo)methyl)-moφholine; 286) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl)-moφholine; 287) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo-lH,4H- l,2,4-triazolo)methyl)-moφholine; 288) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methy l)-moφholine; 289) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methy l)-moφholine; 290) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 291) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo-l ,3- imidazolo)methyl)-moφholine; 292) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 293) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 294) 2-(R)-( 1 -(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 295) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 296) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 297) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 298) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine; 299) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 300) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 301) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 302) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 303) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholine; 304) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 305) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 306) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-moφholine; 307) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- yl)methyl-moφholine; 308) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 309) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 310) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 311) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-moφholine; 312) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl- moφholine; 313) 2-(R)-(l -(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl- moφholine; 314) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 315 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-ρhenyl-4-(3-lH,4H- 1 ,2,4-triazolo)methyl-moφholine; 316 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3- 1 H,4H- 1 ,2,4-triazolo)methyl-moφholine; 317 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (3- 1 H,4H- 1 ,2,4-triazolo)methy 1-moφholine; 318 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 319 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo)- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 320 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3- (5-oxo- lH,4H-l ,2,4-triazolo)methyl)-moφholine; 321 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 322 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)- moφholine; 323 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 324 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 325 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 326 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 327 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 328 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 329 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (2-imidazolo)methyl-moφholine; 330 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 331 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 332 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 333 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (4-imidazolo)methyl-moφholine; 334 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 335 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 336 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 337 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (5-tetrazolo)methyl-moφholine; 338 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 339 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 340 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- oxo-5H-pyrrol-4-yl)methyl-moφholine; 341 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 342 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 343 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-moφholine; 344 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 345 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-moφholine; 346 2-(R)-( 1 -(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)pheny 1- moφholine; 347 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 348 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(l ,2,4- triazolo)methyl-moφholine; 349) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 350) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl-moφholine; 351) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo-lH,4H- 1 ,2,4-triazolo)methyl-moφholine; 352) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl-moφholine; 353) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 354) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 355) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo-l ,3- imidazolo)methyl-moφholine; 356) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 357) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 358) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 359) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 360) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 361) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 362) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine; 363) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 364) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 365) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 366) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 367) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholine; 368) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)ρhenyl-4-(5- tetrazolo)methyl-moφholine; 369) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 370) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-moφholine; 371) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- yl)methyl-moφholine; 372) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 373) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 374) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 375) 4-(4-(imidazolo)methyl)-2-(3-(tert-butyl)-5-(trifluoromethyl)- benzyloxy)-3-phenyl-moφholine; 376) 2-(R)-(2,5-bis(trifluoromethyl)benzoyloxy)-3-(S)-(4- fluorophenyl)-4-benzyl-moφholine; 377) 2-(R)-(l-(2,5-bis(trifluoromethyl)phenyl)ethenyloxy)-3-(S)-(4- fluorophenyl)-4-benzyl-moφholine; 378) 2-(R)-(l-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-moφholine; 379) 2-(R)-(l-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoropheny l)-4-(3 -(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 380) 2-(R)-(l-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 381) 2-(R)-(l-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 382) 2-(R)-(l -(R)-(3-(thiomethyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 383) 2-(R)-(l -(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo- 1 H,4H- 1 ,2,4-triazolo)methy l)-moφholine; 384) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 385) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl)-moφholine; 386) 2-(R)-(l-(R)-(3-(thiomethyl)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-moφholine; 387) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 388) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 389) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 390) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyl-moφholine; 391) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 392) 2-(R)-(l -(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyI-4-(3-(l ,2,4- triazolo)methyl)-moφholine; 393) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-l ,3- imidazolo)methyl)-moφholine; 394) 2-(R)-(l -(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 395) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1 H,4H- 1 ,2,4-triazolo)methy l)-moφholine; 396 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 397 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 398 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)-ethoxy)-3- (S)-(4-fluorophenyl)-moφholine; 399 2-(R)-( 1 -(R)-(3-(fluoropheny l)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluorophenyl)-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 400 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluoroρhenyl)-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 401 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluorophenyl)-4-(4-(2-oxo-l ,3-imidazolo)methyl)-moφholine; 402 2-(R)-( 1 -(R)-(3-(chloro)-5-(trifluoromethyl)phenyl)-ethoxy)-3- (S)-(4-fluorophenyl)-moφholine; 403 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 404 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluoro)ρhenyl -4-(3-(l ,2,4-triazolo)methyl)-moφholine; 405 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-(2-oxo-l ,3-imidazolo)methyl)-moφholine; 406 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 407 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 408 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 409 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 410 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 411 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 412 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 413 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 414 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 415 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 416 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 417 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 418 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 419 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 420 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 421 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 422 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 423 2-(R)-(l-(R)-(3-(isopropoxy)ρhenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 424 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 425 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3-(isoproρoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4- triazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3-(isoproρoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3-(isoproρoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3 -(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 440 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 441 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 442 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-moφholine; 443 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 444 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 445 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 446 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 447 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 448 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 449 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 450 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 451 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3 -(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 452 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 453 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 454 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-moφholine; 455) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H- 1,2,4- triazolo)methyl)-moφholine; 456) 2-(R)-( 1 -(R)-(3 ,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy )- 3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 457) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 458) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-moφholine; 459) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H- 1 ,2,4- triazolo)methyl)-moφholine; 460) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 461 ) 2-(R)-( 1 -(R)-(3 ,5-bis(trifluoromethy l)-4-(chloro)pheny l)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)- moφholine; 462) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 463) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 464) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 465) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 466) 2-(R)-(l -(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)pheny 1-moφholine ; 467) 2-(R)-(l -(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 468) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 469) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 470) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 471) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3- (5-oxo- 1 H,4H-1 ,2,4-triazolo)methyl)-moφholine; 472) 2-(R)-(l -(R)-(l -(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 473) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methy l)-moφholine; 474) 2-(R)-(l-(R)-(l -(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 475) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3 -(5-oxo- 1H,4H-1 , 2,4-triazolo)methyl)- moφholine; 476) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 477) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 478) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 479) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 480) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 481) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 482) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 483) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)ρhenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 484 2-(R)-(l-(R l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)pheny -4-(3-(l ,2,4-triazolo)methyl)-moφholine; 485 2-(R)-(l-(R)- l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)pheny ■ 4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 486 2-(R)-(l-(R)- l -(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)pheny -moφholine; 487 2-(R)-(l-(R)- l-(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)pheny ■4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)- moφholine; 488 2-(R)-(l-(R)- l-(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)pheny -4-(3-(l,2,4-triazolo)methyl)-moφholine; 489 2-(R)-(l-(R)- l-(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)pheny -4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 490 2-(R)-(l-(R)- l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)pheny -moφholine; 491 2-(R)-(l-(R)- l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)pheny •4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 492 2-(R)-(l-(R)- l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)pheny -4-(3-(l ,2,4-triazolo)methyl)-moφholine; 493 2-(R)-(l-(R)- l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)pheny -4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 494 2-(R)-(l-(R)- 3-(thiomethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)pheny moφholine; 495 2-(R)-(l-(R)- 3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)pheny •4-(3 -(5-oxo- 1H,4H-1, 2,4-triazolo)methyl)- moφholine; 496 2-(R)-(l-(R)- 3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)pheny -4-(3-(l ,2,4-triazolo)methyl)-moφholine; 497 2-(R)-(l-(R)- 3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)pheny ■4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 498 2-(R)-(l-(R)- 3-(thiomethyl)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-moφholine; 499) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4- triazolo)me yl)-moφholine; 500) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 501) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 502) 2-(R)-(l -(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-moφholine; 503) 2-(R)-(l -(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 504) 2-(R)-(l -(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(l ,2,4- triazolo)methyl)-moφholine; 505) 2-(R)-(l -(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-l ,3- imidazolo)methyl)-moφholine; 506) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 507) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lK,4H-l,2,4-triazolo)methyl)- moφholine; 508) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 509) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 510) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-moφholine; 511) 2-(R)-( 1 -(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- l ,2,4-triazolo)methyl)-moφholine; 512) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(3-(l ,2,4- triazolo)methyl)-moφholine; 513) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-l,3- imidazolo)methyl)-moφholine; 1) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl moφholine; 5) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5- oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; >) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(l ,2,4- triazolo)methyl)-moφholine; 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2- oxo- 1 ,3-imidazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-moφholine; ) ) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; )) 2-(R)-(l -(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(l ,2,4- triazolo)methyl)-moφholine; i) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo- 1 ,3-imidazolo)methyl)-moφholine; I) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 5) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; I) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl)-moφholine; 5) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; ) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-moφholine; 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 2-(R)-(l -(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(l ,2,4- triazolo)methyl)-moφholine; )) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo- 1 ,3-imidazolo)methyl)-moφholine; )) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 531) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 532) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l ,2,4-triazolo)methyl)-moφholine; 533) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo-l ,3-imidazolo)methyl)-moφholine; 534) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-moφholine; 535) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)- moφholine; 536) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 537) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 538) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-moφholine; 539) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 540) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 541) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 542) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-moφholine; 543) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(3-(5-oxo-lH,4H- 1 ,2,4-triazolo)methyl)- moφholine; 544) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 545) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 546) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-moφholine; 547) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(3 -(5-oxo- 1H,4H-1 , 2,4-triazolo)methyl)- moφholine; 548) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 549) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 550) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-moφholine; 551) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 552) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 553) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 554) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-moφholine; 555) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 556) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 557) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 558) 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 559) 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 560) 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 561 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 562 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 563 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(4- (2-oxo-l, 3 -imidazolo)methyl)-moφholine; 564 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(l,2,4-triazolo)methyl)-moφholine; 565 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo-l ,3-imidazolo)methyl)-moφholine; 566 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 567 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 568 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(l ,2,4-triazolo)methyl)-moφholine; 569 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 570 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 571 2-(R)-(l- R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(4- (2-oxo-l , 3 -imidazolo)methyl)-moφholine; 572 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-ρhenyl-4-(3-(- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 573 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-ρhenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 574 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(-lH,4H-l,2,4-triazolo)methyl)-moφholine; 575 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 576 2-(R)-( 1 -(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- pheny l-4-(3-(- 1 H,4H- 1 ,2,4-triazolo)methy l)-moφholine; 577 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4_(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(-lH,4H-l,2,4-triazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(4-(2-oxo-l ,3-imidazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(-lH,4H-l ,2,4-triazolo)methyl)-moφholine; 2-(R)-(l -(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(-lH,4H-l,2,4-triazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(-lH,4H-l ,2,4-triazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(- 1 H,4H-1 ,2,4-triazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl)-moφholine; 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-phenyl-4-(3-(l ,2,4- triazolo)methyl)-moφholine; 595) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-phenyl _4-(4-(2-oxo-l,3- imidazolo)methyl)-moφholine; 596) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3- (S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 597) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3- (S)-phenyl-4-(4- (2-oxo- l,3-imidazolo)methyl)-moφholine; 598) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3- (S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφhoIine; 599) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3- (S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 600) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3- (S)-phenyl-4-(3- ( 1 ,2,4-triazolo)methyl)-moφholine; 601) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3- (S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; and pharmaceutically acceptable salts thereof. Representative examples of the nomenclature employed herein are given below: 439) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; HN NH Y O 449) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 468) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-2-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine. Specific compounds within the scope of the present invention include: (1) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-4-(3-(5- oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)moφholine N-oxide; (2) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-4-(3-(4- (ethoxycarbonyloxy- 1 -ethyl)5-oxo- 1 H,- 1 ,2,4-triazolo)- methyl)moφholine; (3) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)-phenyl-4-(3-(4-monophosphory 1-5-oxo- IH,- 1,2,4- triazolo)methyl)moφholine; (4) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)-phenyl-4-(3-( 1 -monophosphoryl-5-oxo- 1 H,- 1 ,2,4- triazolo)methyl)moφholine; (5) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)-phenyl-4-(3-(2-monophosphoryl-5-oxo-lH,- 1,2,4- triazolo)methyl)moφholine; (6) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)-phenyl-4-(3-(5-oxyphosphoryl-lH,-l,2,4-triazolo)- methyl)moφholine; (7) 2-(S)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)-phenyl-4-(3-(l -phosphoryl-5-oxo-4H- 1 ,2,4- triazolo)methyl)moφholine; or a pharmaceutically acceptable salt thereof. Particularly prefered compounds include those wherein the pharmaceutically acceptable salt is the bis(N-methyl-D-glucamine) salt. Specific compounds within the scope of the present invention also include: 15 30 wherein K + is a pharmaceutically acceptable counterion. TACHYKININ ANTAGONISM ASSAY The compounds of this invention are useful for antagonizing tachykinins, in particular substance P and neurokinin A in the treatment of gastrointestinal disorders, central nervous system disorders, inflammatory diseases, pain or migraine and asthma in a mammal in need of such treatment. This activity can be demonstrated by the following assay. A. Receptor Expression in COS To express the cloned human neurokinin- 1 receptor (NKIR) transiently in COS, the cDNA for the human NKIR was cloned into the expression vector pCDM9 which was derived from pCDM8 (INVΓTROGEN) by inserting the ampicillin resistance gene (nucleotide 1973 to 2964 from BLUESCRIPT SK+) into the Sac II site. Transfection of 20 ug of the plasmid DNA into 10 million COS cells was achieved by electroporation in 800 ul of transfection buffer (135 mM NaCl, 1.2 mM CaCl2, 1.2 mM MgCl2, 2.4 mM K2HPO4, 0.6 mM KH2PO4, 10 mM glucose, 10 mM HEPES pH 7.4) at 260 V and 950 uF using the IBI GENEZAPPER (IBI, New Haven, CT). The cells were incubated in 10% fetal calf serum, 2 mM glutamine, lOOU/ml penicillin- streptomycin, and 90% DMEM media (GIBCO, Grand Island, NY) in 5% C02 at 37 °C for three days before the binding assay. B. Stable Expression in CHO To establish a stable cell line expressing the cloned human NKIR, the cDNA was subcloned into the vector pRcCMV (INVITROGEN). Transfection of 20 ug of the plasmid DNA into CHO cells was achieved by electroporation in 800 ul of transfection buffer suplemented with 0.625 mg/ml Herring sperm DNA at 300 V and 950 uF using the IBI GENEZAPPER (IBI). The transfected cells were incubated in CHO media [10 % fetal calf serum, 100 U/ml pennicilin- streptomycin, 2 mM glutamine, 1/500 hypoxanthine-thymidine (ATCC), 90% IMDM media (JRH BIOSCIENCES, Lenexa, KS), 0.7 mg/ml G418 (GIBCO)] in 5% C02 at 37°C until colonies were visible. Each colony was separated and propagated. The cell clone with the highest number of human NKIR was selected for subsequent applications such as drug screening. C. Assay Protocol using COS or CHO The binding assay of human NKIR expressed in either COS or CHO cells is based on the use of 125i-substance P (125I-SP, from DU PONT, Boston, MA) as a radioactively labeled ligand which competes with unlabeled substance P or any other ligand for binding to the human NKIR. Monolayer cell cultures of COS or CHO were dissociated by the non-enzymatic solution (SPECIALTY MEDIA, Lavallette, NJ) and resuspended in appropriate volume of the binding buffer (50 mM Tris pH 7.5, 5 mM MnCl2, 150 mM NaCl, 0.04 mg/ml bacitracin, 0.004 mg/ml leupeptin, 0.2 mg/ml BSA, 0.01 mM phosphoramidon) such that 200 ul of the cell suspension would give rise to about 10,000 cpm of specific 125I-SP binding (approximately 50,000 to 200,000 cells). In the binding assay, 200 ul of cells were added to a tube containing 20 ul of 1.5 to 2.5 nM of 125I-SP and 20 ul of unlabeled substance P or any other test compound. The tubes were incubated at 4°C or at room temperature for 1 hour with gentle shaking. The bound radioactivity was separated from unbound radioactivity by GF/C filter (BRANDEL, Gaithersburg, MD) which was pre-wetted with 0.1 % polyethylenimine. The filter was washed with 3 ml of wash buffer (50 mM Tris pH 7.5, 5 mM MnCl2, 150 mM NaCl) three times and its radioactivity was determined by gamma counter. The activation of phospholipase C by NKIR may also be measured in CHO cells expressing the human NKIR by determining the accumulation of inositol monophosphate which is a degradation product of IP3. CHO cells are seeded in 12-well plate at 250,000 cells per well. After incubating in CHO media for 4 days, cells are loaded with 0.025 uCi/ml of 3H-myoinositol by overnight incubation. The extracellular radioactivity is removed by washing with phosphate buffered saline. LiCl is added to the well at final concentration of 0.1 mM with or without the test compound, and incubation is continued at 37°C for 15 min. Substance P is added to the well at final concentration of 0.3 nM to activate the human NKIR. After 30 min of incubation at 37°C, the media is removed and 0.1 N HCl is added. Each well is sonicated at 4°C and extracted with CHCl3/methanol (1 :1). The aqueous phase is applied to a 1 ml Dowex AG 1X8 ion exchange column. The column is washed with 0.1 N formic acid followed by 0.025 M ammonium formate -0.1 N formic acid. The inositol monophosphate is eluted with 0.2 M ammonium formate-0.1 N formic acid and quantitated by beta counter. The compounds of Formula I as exemplified in the Examples below have been found to displace radioactive ligand for the neurokinin- 1 receptor at a concentration range of 0.01 nM to 1.0 μM. The activity of the present compounds may also be demonstrated by the assay disclosed by Lei, et al., British J. Pharmacol.. 105. 261-262 (1992). The compounds of the present invention are useful in the prevention and treatment of a wide variety of clinical conditions which are characterized by the presence of an excess of tachykinin, in particular substance P, activity. These conditions may include disorders of the central nervous system such as anxiety, depression, psychosis and schizophrenia; neurodegenerative disorders such as AIDS related dementia, senile dementia of the Alzheimer type, Alzheimer's disease and Down's syndrome; demyelinating diseases such as multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease) and other neuropathological disorders such as peripheral neuropathy, for example AIDS related neuropathy, diabetic neuropathy, chemotherapy- induced neuropathy, and postheφetic and other neuralgias; respiratory diseases such as chronic obstructive airways disease, bronchopneumonia, chronic bronchitis, bronchospasm and asthma; airways disease modulated by neurogenic inflammation; diseases characterized by neurogenic mucus secretion, such as cystic fibrosis; diseases associated with decreased glandular secretions, including lacrimation, such as Sjogren's syndrome, hyperlipoproteinemias IV and V, hemochromatosis, sarcoidosis, or amyloidosis; inflammatory diseases such as inflammatory bowel disease, irritable bowel syndrome, psoriasis, fibrositis, ocular inflammation, osteoarthritis and rheumatoid arthritis; allergies such as eczema and rhinitis; hypersensitivity disorders such as poison ivy; ophthalmic diseases such as conjunctivitis, vernal conjunctivitis, dry eye syndrome, and the like; cutaneous diseases such as contact dermatitis, atropic dermatitis, urticaria, and other eczematoid dermatitis; oedema, such as oedema caused by thermal injury; addiction disorders such as alcholism; stress related somatic disorders; reflex sympathetic dystrophy such as shoulder/hand syndrome; dysthymic disorders; adverse immunological reactions such as rejection of transplanted tissues and disorders related to immune enhancement or suppression, such as systemic lupus erythematosis; gastrointestinal (GI) disorders and diseases of the GI tract such as disorders associated with the neuronal control of viscera such as ulcerative colitis, Crohn's disease and incontinence, nausea or emesis, including acute, delayed, post-operative, late-phase, and anticipatory emesis, for example, induced by chemotherapy, radiation, toxins, pregnancy, vestibular disorder, motion, post-opearative sickness, surgery, gastrointestinal obstruction, reduced gastrointestinal motility, visceral pain, migraine, opioid analgesics and variations in intercranial pressure (except quaternary salts); disorders of bladder function such as bladder detrusor hyperreflexia; fibrosing and collagen diseases such as scleroderma and eosinophilic fascioliasis; disorders of blood flow caused by vasodilation and vasospastic diseases such as angina, migraine and Reynaud's disease; and pain or nociception, for example, chronic pain or that attributable to or associated with any of the foregoing conditions especially the transmission of pain in migraine. Hence, these compounds may be readily adapted to therapeutic use for the treatment of physiological disorders associated with an excessive stimulation of tachykinin receptors, especially neurokinin- 1, and as neurokinin- 1 antagonists in the control and/or treatment of any of the aforesaid clinical conditions in mammals, including humans. The compounds of the present invention are also of value in the treatment of a combination of the above conditions, in particular in the treatment of combined post-operative pain and post-operative nausea and vomiting. The compounds of the present invention are particularly useful in the treatment of nausea or emesis, including acute, delayed, post-operative, late-phase, and anticipatory emesis, such as emesis or nausea induced by for example chemotherapy, radiation, surgery, migraine, toxins, such as metabolic or microbial toxins, viral or bacterial infections, pregnancy, vestibular disorder, motion, mechanical stimulation, gastrointestinal obstruction, reduced gastrointestinal motility, visceral pain, psychological stress or disturbance, high altitude, weightlessness, opioid analgesics, intoxication, resulting for example from consumption of alcohol, and variations in intercranial pressure. Most especially, this compound is of use in the treatment of emesis induced by antineoplastic (cytotoxic) agents including those routinely used in cancer chemotherapy. Examples of such chemotherapeutic agents include alkylating agents, for example, nitrogen mustards, ethyleneimine compounds, alkyl sulfonates and other compounds with an alkylating action such as nitrosoureas, cisplatin, and dacarbazine; antimetabolites, for example, folic acid, purine or pyrimidine antagonists; mitotic inhibitors, for example, vinca alkaloids and derivatives of podophyllotoxin; and cytotoxic antibiotics. Particular examples of chemotherapeutic agents are described, for example, by D. J. Stewart in "Nausea and Vomiting: Recent Research and Clinical Advances", Eds. J. Kucharczyk, et al., CRC Press Inc., Boca Raton, Florida, USA (1991), pages 177-203, especially page 188. Commonly used chemotherapeutic agents include cisplatin, dacarbazine (DTIC), dactinomycin, mechlorethamine (nitrogen mustard), streptozocin, cyclophosphamide, carmustine (BCNU), lomustine (CCNU), doxorubicin (adriamycin), daunorubicin, procarbazine, mitomycin, cytarabine, etoposide, methotrexate, 5- fluorouracil, vinblastine, vincristine, bleomycin, and chlorambucil [R. J. Gralla, et aL, Cancer Treatment Reports. 68(1), 163-172 (1984)]. The compounds of the present invention are also of use in the treatment of emesis induced by radiation including radiation therapy such as in the treatment of cancer, or radiation sickness, and in the treatment of post-operative nausea and vomiting. The compounds of the present invention are also of use in the prevention or treatment of disorders of the central nervous system such as anxiety, psychosis and schizophrenia; neurodegenerative disorders such as senile dementia of the Alzheimer type, Alzheimer's disease and Down's syndrome; respiratory diseases, particularly those associated with excess mucus secretion, such as chronic obstructive airways disease, broncho-pneumonia, chronic bronchitis, cystic fibrosis and asthma, and bronchospasm; inflammatory diseases such as inflammatory bowel disease, osteoarthritis and rheumatoid arthritis; adverse immunological reactions such as rejection of transplanted tissues; gastrointestinal (GI) disorders and diseases of the GI tract such as disorders associated with the neuronal control of viscera such as ulcerative colitis, Crohn's disease and incontinence; disorders of blood flow caused by vasodilation; and pain or nociception, for example, that attributable to or associated with any of the foregoing conditions or the transmission of pain in migraine (both prophylaxis and acute treatment). As calcium channel blocking agents some of the compounds of the present invention are useful in the prevention of treatment of clinical conditions which benefit from inhibition of the transfer of calcium ions across the plasma membrane of cells. These include diseases and disorders of the heart and vascular system such as angina pectoris, myocardial infarction, cardiac arrhythmia, cardiac hypertrophy, cardiac vasospasm, hypertension, cerebrovascular spasm and other ischemic disease. Furthermore, these compounds may be capable of lowering elevated intraocular pressure when administered topically to the hypertensive eye in solution in a suitable ophthalmic vehicle. Also, these compounds may be useful in the reversal of multidrug resistance in tumor cells by enhancing the efficacy of chemotherapeutic agents. In addition, these compounds may have activity in blocking calcium channels in insect brain membranes and so may be useful as insecticides. The compounds of the present invention are particularly useful in the treatment of pain or nociception and/or inflammation and disorders associated therewith such as, for example: neuropathy, such as diabetic or peripheral neuropathy and chemotherapy-induced neruopathy; postheφetic and other neuralgias; asthma; osteoarthritis; rheumatoid arthritis; and especially migraine. The compounds of the present invention are also particularly useful in the treatment of diseases characterized by neurogenic mucus secretion, especially cystic fibrosis. For the treatment of certain conditions it may be desirable to employ a compound of the present invention in conjunction with another pharmacologically active agent. For example, a compound of the present invention may be presented together with another therapeutic agent as a combined preparation for simultaneous, separate, or sequential use for the relief of emesis. Such combined preparations may be, for example, in the form of a twin pack. A preferred combination comprises a compound of the present invention with a chemotherapeutic agent such as an alkylating agent, antimetabolite, mitotic inhibitor, or cytotoxic antibiotic, as described above. In general, the currently available dosage forms of the known therapeutic agents for use in such combinations will be suitable. Similarly, for the treatment of respiratory diseases, such as asthma, a compound of the present invention may be used in conjunction with a bronchodilator, such as a β2-adrenergic receptor agonist or a tachykinin antagonist which acts at neurokinin-2 receptors. Suitable β2-adrenergic receptor agonist include: Bambuterol (US 4,419,364 issued to Draco on 12/6/83); Bitolterol mesylate (US 4,138,581 issued to Sterling 2/6/79); Brosaterol (US 4,276,299 issued to Zambon 6/30/81 and US 4,520,200 issued to Zambon 5/28/85); Carbuterol (US 3,763,232 issued to Smith Kline 10/2 73); Clenbuterol (US 3,536,712 issued to Boehringer Ingelheim 10/27 70); Cimaterol (US 4,407,819 issued to American Cyanamid 10/4/83); Docaφamine (US 4,228,183 issued to Tanabe 10/14/80); Dopexamine (US 4,645,768 issued to Fisons 2/24/87); Formoterol (US 3,994,974 issued to Yamanouchi 11/30/76); Mabuterol (US 4,119,710 issued to Boehringer Ingelheim 10/10/78); Pirbuterol hydrochloride (US 3,700,681 issued to Pfizer 10/24/72); Procaterol hydrochloride (US 4,026,897 issued to Otsuka 5/31/77); Ritodrine hydrochloride (US 3,410,944 issued to North American Philips 11/12/68); or Salmeterol (US 4,992,474 issued to Glaxo 2/21/91 and US 5,091,422 issued to Glaxo 2/25/92). Also, for the treatment of conditions that require antagonism of both neurokinin- 1 and neurokinin-2, including disorders associated with bronchoconstriction and/or plasma extravasation in airways, such as asthma, chronic bronchitis, airways disease, or cystic fibrosis; neuropathy, such as diabetic or peripheral neuropathy and chemotherapy-induced neuropathy; osteoarthritis; rheumatoid arthritis; and migraine, a compound of the present invention may be used in conjunction with a tachykinin antagonist which acts at neurokinin-2 receptors, or with tachykinin receptor antagonist which acts at both neurokinin- 1 and neurokinin-2 receptors. Likewise, a compound of the present invention may be employed with a leucotriene antagonist, such a leucotriene D4 antagonist, exemplfied by those disclosed in Patent Pub. EP 0,480,717, published April 15, 1992; Patent Pub. EP O 604,114, published June 1994; US Patent No. 5,270,324, issued December 14, 1993; and US Patent No. 4,859,692, issued August 22, 1989. This combination is particularly useful in the treatment of respiratory diseases such as asthma, chronic bronchitis and cough. A compound of the present invention further may be used in combination with a corticosteroid such as Dexamethasone, Kenalog, Aristocort, Nasalide, Preferid, Benecorten or others such as disclosed in U.S.Patent Nos. 2,789,118, 2,990,401 , 3,048,581, 3,126,375, 3,929,768, 3,996,359, 3,928,326 and 3,749,712. Similarly, for the prevention or treatment of emesis a compound of the present invention may be used in conjunction with other anti-emetic agents, especially 5HT3 receptor antagonists, such as ondansetron, granisetron, tropisetron, decadron, and zatisetron, or GABAβ receptor agonists, such as baclofen. Likewise, for the prevention or treatment of migraine a compound of the present invention may be used in conjunction with other anti-migraine agents, such as ergotamines or 5HTi agonists, especially sumatriptan. Likewise, for the treatment of behavioral hyperalgesia, a compound of the present invention may be used in conjunction with an antagonist of N-methyl D-aspartate (NMD A), such as dizocilpine. For the prevention or treatment of inflammatory conditions in the lower urinary tract, especially cystitis, a compound of the present invention may be used in conjunction with an antiinflammatory agent, such as a bradykinin receptor antagonist. The compound of the present invention and the other pharmacologically active agent may be administered to a patient simultaneously, sequentially or in combination. In the treatment of the clinical conditions noted above, the compounds of this invention may be utilized in compositions such as tablets, capsules or elixirs for oral administration, suppositories for rectal administration, sterile solutions or suspensions for parenteral or intramuscular administration, and the like. The pharmaceutical compositions of this invention can be used in the form of a pharmaceutical preparation, for example, in solid, semisolid or liquid form, which contains one or more of the compounds of the present invention, as an active ingredient, in admixture with an organic or inorganic carrier or excipient suitable for external, enteral or parenteral applications. The active ingredient may be compounded, for example, with the usual non- toxic, pharmaceutically acceptable carriers for tablets, pellets, capsules, suppositories, solutions, emulsions, suspensions, and any other form suitable for use. The carriers which can be used are water, glucose, lactose, gum acacia, gelatin, mannitol, starch paste, magnesium trisilicate, talc, corn starch, keratin, colloidal silica, potato starch, urea and other carriers suitable for use in manufacturing preparations, in solid, semisolid, or liquid form, and in addition auxiliary, stabilizing, thickening and coloring agents and perfumes may be used. The active object compound is included in the pharmaceutical composition in an amount sufficient to produce the desired effect upon the process or condition of the disease. For preparing solid compositions such as tablets, the principal active ingredient is mixed with a pharmaceutical carrier, e.g. conventional tableting ingredients such as corn starch, lactose, sucrose, sorbitol, talc, stearic acid, magnesium stearate, dicalcium phosphate or gums, and other pharmaceutical diluents, e.g. water, to form a solid preformulation composition containing a homogeneous mixture of a compound of the present invention, or a non-toxic pharmaceutically acceptable salt thereof. When referring to these preformulation compositions as homogeneous, it is meant that the active ingredient is dispersed evenly throughout the composition so that the composition may be readily subdivided into equally effective unit dosage forms such as tablets, pills and capsules. This solid preformulation composition is then subdivided into unit dosage forms of the type described above containing from 0.1 to about 500 mg of the active ingredient of the present invention. The tablets or pills of the novel composition can be coated or otherwise compounded to provide a dosage form affording the advantage of prolonged action. For example, the tablet or pill can comprise an inner dosage and an outer dosage component, the latter being in the form of an envelope over the former. The two components can be separated by an enteric layer which serves to resist disintegration in the stomach and permits the inner component to pass intact into the duodenum or to be delayed in release. A variety of materials can be used for such enteric layers or coatings, such materials including a number of polymeric acids and mixtures of polymeric acids with such materials as shellac, cetyl alcohol and cellulose acetate. The liquid forms in which the novel compositions of the present invention may be incoφorated for administration orally or by injection include aqueous solution, suitably flavoured syrups, aqueous or oil suspensions, and flavoured emulsions with edible oils such as cottonseed oil, sesame oil, coconut oil or peanut oil, as well as elixirs and similar pharmaceutical vehicles. Suitable dispersing or suspending agents for aqueous suspensions include synthetic and natural gums such as tragacanth, acacia, alginate, dextran, sodium carboxymethylcellulose, methylcellulose, polyvinylpyrrolidone or gelatin. Dispersible powders and granules suitable for preparation of an aqueous suspension by the addition of water provide the active ingredient in admixture with a dispersing or wetting agent, suspending agent and one or more preservatives. Suitable dispersing or wetting agents and suspending agents are exemplified by those already mentioned above. Additional excipients, for example, sweetening, flavoring and coloring agents, may also be present. Compositions for inhalation or insufflation include solutions and suspensions in pharmaceutically acceptable, aqueous or organic solvents, or mixtures thereof, and powders. The liquid or solid compositions may contain suitable pharmaceutically acceptable excipients as set out above. Preferably the compositions are administered by the oral or nasal respiratory route for local or systemic effect. Compositions in preferably sterile pharmaceutically acceptable solvents may be nebulized by use of inert gases. Nebulized solutions may be breathed directly from the nebulizing device or the nebulizing device may be attached to a face mask, tent or intermittent positive pressure breathing machine. Solution, suspension or powder compositions may be administered, preferably orally or nasally, from devices which deliver the formulation in an appropriate manner. For the treatment of the clinical conditions and diseases noted above, the compounds of this invention may be administered orally, topically, parenterally, by inhalation spray or rectally in dosage unit formulations containing conventional non-toxic pharmaceutically acceptable carriers, adjuvants and vehicles. The term parenteral as used herein includes subcutaneous injections, intravenous, intramuscular, intrasternal injection or infusion techniques. The compounds of this invention may be administered to patients (animals and human) in need of such treatment in dosages that will provide optimal pharmaceutical efficacy. The dose will vary from patient to patient depending upon the nature and severity of disease, the patient's weight, special diets then being followed by a patient, concurrent medication, and other factors which those skilled in the art will recognize. In the treatment of a condition associated with an excess of tachykinins, an appropriate dosage level will generally be about 0.001 to 50 mg per kg patient body weight per day which may be administered in single or multiple doses. Preferably, the dosage level will be about 0.01 to about 25 mg/kg per day; more preferably about 0.05 to about 10 mg/kg per day. For example, in the treatment of conditions involving the neurotransmission of pain sensations, a suitable dosage level is about 0.001 to 25 mg/kg per day, preferably about 0.05 to 10 mg/kg per day, and especially about 0.1 to 5 mg/kg per day. A compound may be administered on a regimen of 1 to 4 times per day, preferably once or twice per day. In the treatment of emesis using an injectable formulation, a suitable dosage level is about 0.001 to 10 mg/kg per day, preferably about 0.005 to 5 mg/kg per day, and especially about 0.05 to 5 mg/kg per day. A compound may be administered on a regimen of 1 to 4 times per day, preferably once or twice per day. Several methods for preparing the compounds of this invention are illustrated in the following Schemes and Examples wherein wherein R2, R3, R6, R7, R8, Rl 1 , Rl2, Rl3, A, B, p, Y and Z are as defined above. ABBREVIATIONS USED IN SCHEMES AND EXAMPLES Table 1 Reagents: Et3N triethylamine PI13P triphenylphosphine TFA trifluoroacetic acid NaOEt sodium ethoxide DCC N,N'-dicyclohexylcarbodiimide DCU N,N'-dicyclohexylurea CDI 1 , 1 '-carbonyldiimidazole MCPBA m-chloroperbenzoic acid DBU 1 ,8-diazabicyclo[5.4.0]undec-7-ene Cbz-Cl benzyl chloroformate ACE-C1 alpha-chloroethyl chloroformate iPr2NEt or DIEA N,N-diisopropylethylamine NHS N-hydroxysuccinimide DIBAL diisobutylaluminum hydride SCHEME 1 iPrOH, Δ SCHEME 2 XI SCHEME3 iPrOH, Δ SCHEME 4 SCHEME 5 SCHEME6 10 Ph 1)LiOH, THF/water 2) H 2 , Pd/C, HOAc/water 25 30 SCHEME7 1)L-Selectride, -78 °C SCHEME 7 (CONT'D) SCHEME8 S = H 2 or R 14 -CH 2 - SCHEME 8 (CONT'D) 15 S = H, or R 14 -CH- 25 30 SCHEME9 SCHEME 10 25 30 SCHEME11 SCHEME 12 30 30 SCHEME 13 (CONTD.) 30 SCHEME 14 25 30 SCHEME 15 30 The compounds of the present invention in which Y = O may be prepared by the general route outlined in Scheme 1. Thus, the appropriately substituted α-bromo-phenylacetaldehyde, dimethyl acetal I (prepared using the method of Jacobs in Journal of the American Chemical Society. 1953, 75, 5500) may be converted to the dibenzyl acetal II by stirring I and a slight excess of a benzyl alcohol in the presence of an acid catalyst with concommitant removal of methanol. Alkylation of a substituted amino alcohol by benzyl bromide II may give N-alkyl amino alcohol HI; use of a chiral amino alcohol would result in the formation of diastereomers and these may be separated at this (or at a later) stage using standard chromatographic methods. N- Alkylation or N-acylation of III may give the dialkyl- or acyl/alkyl- amino alcohol IV in which the group A-B may serve as a protecting group or be used as or elaborated into a substituent in the final target compound. Cyclization to give substituted moφholine V may be realized by warming a solution of IV and an acid catalyst. Diastereomers of V that may be formed may be separated using standard chromatographic methods. If A-B is a protecting group, it may be removed using known procedures (Greene, T.W., Wuts, P.G.M. Protective Groups in Organic Synthesis, 2nd ed., John Wiley & Sons, Inc., New York, 1991). If the preparation of I-V results in the formation of enantiomers, these may be resolved by alkylating or acylating V (A-B = H) with a chiral auxiliary, separating the diastereomers thus formed using known chromatographic methods, and removing the chiral auxiliary to give the enantiomers of V. Alternatively, the diastereomers of V may be separated via fractional crystallization from a suitable solvent of the diastereomeric salts formed by V and a chiral organic acid. The compounds of the present invention in which Y = CH2 may be prepared by the general route outlined in Scheme 2. Thus, the N-methoxy-N-methyl amide of a protected phenyl glycine VI (prepared from the carboxylic acid via the mixed anhydride according to the procedure of Rapoport in Journal of Organic Chemistry. 1985, 50, 3972) may be used to acylate the lithium enolate of methyl diethylphosphonate to give the ketophosphonate VII. The sodium salt of VII may be condensed with an appropriately substituted benzaldehyde to give the ,β-unsaturated ketone VIII. Reduction of the ketone and removal of the t-butylcarbamate protecting group may give amino alcohol IX; diastereomers that may form may be separated at this (or at a later) stage using standard chromatographic techniques. Williamson etherification of IX using a substituted chloroacetate, followed by warming, may result in the formation of morpholinone X. Reduction of the double bond and amide carbonyl may be accomplished in a straightforward manner to give the substituted moφholine XI. If the preparation of VI-XI results in the formation of enantiomers, these may be resolved by alkylating or acylating XI (A-B = H) with a chiral auxiliary, separating the diastereomers thus formed using known chromatographic methods, and removing the chiral auxiliary to give the enantiomers of XI. Alternatively, the diastereomers of XI may be separated via fractional crystallization from a suitable solvent of the diastereomeric salts formed by XI and a chiral organic acid. If it is desired that A-B is other than H, the moφholine nitrogen of XI may be further functionalized using standard methods for the alkylation or acylation of secondary amines. If it is desired that R2 is other than H, moφholinone X may be elaborated into the carbinolcarbamate (A-B = R02C, R2 = OH), an intermediate that could be alkylated and would allow for variation in R2. The compounds of the present invention in which Y = O may also be prepared by the general route outlined in Scheme 3. Thus, the appropriately substituted a-bromo-acetaldehyde, dimethyl acetal (prepared using the method of Jacobs in Journal of the American Chemical Society. 1953, 75, 5500) may be converted to the acetal by stirring and a slight excess of the appropriate alcohol in the presence of an acid catalyst with concommitant removal of methanol. Alkylation of a substituted amino alcohol by a bromide may give the N-alkyl amino alcohol; use of a chiral amino alcohol would result in the formation of diastereomers and these may be separated at this (or at a later) stage using standard chromatographic methods. N-Alkylation or N-acylation may give the dialkyl- or acyl/alkyl-amino alcohol in which the group A- B may serve as a protecting group or be used as or elaborated into a substituent in the final target compound. Cyclization to give substituted moφholine may be realized by warming a solution with an acid catalyst. Diastereomers that may be formed may be separated using standard chromatographic methods. If A-B is a protecting group, it may be removed using known procedures (Greene, T.W., Wuts, P.G.M. Protective Groups in Organic Synthesis, 2nd ed., John Wiley & Sons, Inc., New York, 1991). If the preparation of such compounds results in the formation of enantiomers, these may be resolved by alkylating or acylating the final product (A-B = H) with a chiral auxiliary, separating the diastereomers thus formed using known chromatographic methods, and removing the chiral auxiliary to give the desired enantiomers. Alternatively, the diastereomers may be separated via fractional crystallization from a suitable solvent of the diastereomeric salts formed by the compound of a chiral organic acid. One method of synthesizing enantiomerically pure substituted moφholines is illustrated in Scheme 4. Protection of enantiomerically pure phenylglycine as the N-benzyl derivative followed by double alkylation with a 1 ,2-dibromoethane derivative leads to the moφholinone. Reduction with an active hydride reagent such as diisobutyl aluminum hydride, lithium aluminum hydride, lithium tri(sec-butyl)-borohydride (L-Selectride®) or other reducing agents leads predominantly to the 2,3-trans moφholine derivatives. Alkylation of the alcohol, removal of the protecting group on nitrogen (for example, with a palladium hydrogenation catalyst or with 1-chloroethyl chloroformate (Olofson in J. Org. Chem.. 1984, 2081 and 2795), and alkylation of the nitrogen (wherein in A-B-CH2- or A-B -CHO = appropriate definitions of A-B are present) produces the 2,3 -trans compounds. One method of producing enantiomerically pure 2,3-cis moφholines is illustrated in Scheme 5. In the first step, formation of the trifluoromethane-sulfonate ester of the appropiate benzyl alcohol (especially benzyl alcohols which are substituted with electron- withdrawing groups such as -N02, -F, -Cl, -Br, -COR, -CF3, etc) is carried out in the presence of an unreactive base, in an inert solvent. Other leaving groups such as iodide, mesylate, tosylate, p-nitrophenyl- sulfonate and the like may also be employed. Appropriate bases include 2,6-di-t-butylpyridine, 2,6-di-t-butyl-4-methyl-pyridine, diisopropyl- ethylamine, potassium carbonate, sodium carbonate, and the like. Suitable solvents include toluene, hexanes, benzene, carbon tetra¬ chloride, dichloromethane, chloroform, dichloroethane, and the like and mixtures thereof. The filtered solution of the triflate is then added to a solution of the intermediate formed when the moφholinone is contacted with an active hydride reagent such as diisobutyl aluminum hydride, lithium aluminum hydride, or lithium tri (sec-butyl)- borohydride (L- Selectride®) at low temperature, preferably from -78°C to -20°C. After several hours at low temperature, workup and purification provides predominantly 2,3-cis substituted products, which may be carried on to final compounds as shown in Scheme 5. Enantiomerically pure phenylglycines substituted on the phenyl ring may be prepared by the procedure shown in Scheme 6 (D.A. Evans, et al, J. Am. Chem. Soc. 1990. 112, 4011). Methods for preparing the nitrogen alkylating agents A-B- CH2-LG (wherein "LG" indicates an appropriately suitable leaving group) used in Scheme 4 and Scheme 5 are based on known literature methods (for A-B = 3-(l,2,4-triazolyl) or 5-(l,2,4-triazol-3-one)-yl and LG = Cl, see Yanagisawa, I.; Hirata, Y.; Ishii, Y. Journal of Medicinal Chemistry. 27, 849 (1984); for A-B = 4-((2H)-imidazol-2-one)-yl or 5- (4-ethoxycarbonyl-(2H)-imidazol-2-one)-yl and X = Br, see Ducschinsky, R., Dolan, L.A. Journal of the American Chemical Society. 7Q, 657 (1948)). One method of producing enantiomerically pure 2,3-cis moφholines that are substituted at the -position of the C2 benzyl ether is shown in Scheme 7. Thus, a substituted 2-moφholinone (prepared as described in Scheme 4) is reacted with an active hydride reagent, such as diisobutylaluminum hydride, lithium aluminum hydride, or lithium tri(sec-butyl)borohydrdide and the resulting reaction intermediate is quenched with a substituted benzoyl halide, anhydride, or other activated acyl transfer reagent. Aqueous work-up affords the 2-benzoyloxy compound shown in Scheme 7. This compound is converted to the corresponding enol ether using a "titanium ylide" generated from reagents such as μ-chloro-μ-methylene-[bis(cyclo- pentadienyl)titanium]dimethylamluminum ("Tebbe Reagent", Tebbe, F.N., Parshall, G.W., Reddy, G.S., Journal of the American Society. 100. 3611 (1978)), dimethyl titanocene (Petasis, N.A., Bzowej, E.I., Journal of the American Chemical Society. 1 12. 6392 (1990)) or the reagent prepared by the reduction of 1,1-dibromoalkanes with zinc and titanium tetrachloride in the presence of N,N,N',N'-tetramethyl- ethylenediamine (Takai, K. et.al., Journal of Organic Chemistry. 52. 4412 (1987)). The resulting enol ether is reduced to its saturated analog by hydrogenation in the presence of a rhodium based catalyst, such as rhodium on alumina or on carbon; if concomitant removal of the N- benzyl group on the moφholine nitrogen is desired, the hydrogenation may be carried out in the presence of palladium on carbon catalyst. If diastereomers are obtained at this juncture, they may be separated using chromatographic methods or by recrystallization of the mixture of diastereomers. Elaboration of the moφholines so obtained to the final product is carried out in manners analogous to those described in Schemes 4 and 5. Methods by which the substitution on the C-3 phenyl ring of the moφholines of the present invention may be introduced or altered is shown in Scheme 8. Thus, a substituted moφholine may be prepared as described in Scheme 4, 5, or 7 from an enantiomerically pure benzyloxy-substituted aryl glycine (prepared as described in the literature (e.g. L-p-benzyloxyphenylglycine may be prepared according to the procedure of Kamiya, et al. Tetrahedron. 35. 323 (1979)) or using the methods described in Scheme 6). Selective cleavage of the benzyl ether via hydrogenolysis or nonselective hydrogenolysis followed by the synthetic sequence shown in Scheme 8 may afford a suitably protected phenolic intermediate. The phenol may be converted to the corresponding aryl triflate (as shown, or using N-phenyl- trifluoromethane-sulfonimide in the presence of a tertiary amine base in methylene chloride) and the triflate converted to the desired functional group using the palladium- or nickel-catalyzed methods described in Ritter, Synthesis. 735 (1993) (and refs. therein). Elaboration to the desired final product may be carried out as described in Scheme 4 or 5. The parent compounds prepared above are converted to their prodrug counteφarts by alkylation, acylation, phosphorylation or sulfonylation to give ether, ester, phosphate or sulfonate derivatives (wherein the parent compounds bear an -X substitutent as defined above) by the general procedures referenced herein, or reasonable modifications thereof. In particular, as depicted in Scheme 9, treatment of, for example, a triazolone or imidazolone-containing tachykinin antagonist with a suitable base, such as n-butyllithium, sodium hydride, potassium hydride, lithium hexamethyldisilazide, sodium hexamethyldisilazide, potassium hexamethyldisilazide or lithium diisopropylamide in THF at low temperature followed by addition of an appropiate phosphoryl transfer reagent, for example tetrabenzyl pyrophosphate, dibenzyl phosphochloridate or dibenzyl phosphofluoridate provides an intermediate with a protected phosphoryl group. Following purification, for example by gravity silica gel chromatography or by reverse phase high pressure liquid chromatography, the dibenzyl ester may be converted into the desired product by hydrogenolysis, for example with hydrogen gas in the presence of palladium on carbon in the presence of two equivalents of a suitable salt forming agent, such as sodium bicarbonate ( to prepare the disodium salt of the phosphoramidate product) or potassium bicarbonate (to prepare the dipotassium salt of the product). The product may be purified by crystallization or by normal or reverse phase chromatography. As depicted in Scheme 10, treatment of, for example, a triazolone or imidazolone-containing tachykinin antagonist with a suitable base, such as diisopropylethylamine, 2,6-dimethylpyridine or triethylamine and 1 -chloroethyl ethyl carbonate (wherein R may be ethyl, -CH2C02CH2phenyl, or -CH2CH2NH-BOC) in a compatible - I l l - solvent such as toluene or dichloroethane, followed by heating the mixture at reflux for 12-24 hr, provides the corresponding N- alkylcarbonate product, which may be purified by flash chromatography. Similarly, the same substrate may be treated with the functionalized carbonate given in Scheme 11 under similar conditions, such as refluxing in toluene in the presence of diisopropylethy lamine, 2,6-dimethylpyridine or triethylamine to provide the N-Boc protected intermediate. Cleavage of the Boc group, for example with trifluoroacetic acid in methylene chloride or with hydrogen chloride in ethyl acetate provides the corresponding salt of the prodrug product. Generation of the N-oxide prodrug of the aforementioned moφholine tachykinin antagonists may be achieved as shown in Scheme 12 simply by treatment with an oxygen-transfer agent, such as a peracid, such as 3-chloroperoxybenzoic acid or trifluoromethylperacetic acid, or with hydrogen peroxide or alkyl hydroperoxides such as t-butyl hydroperoxide in the presence of a transition metal catalyst, or with Caro's acid (H2SO5). Compounds containing linking groups between the heterocycle and the phosphoryl group may also be prepared, for example as illustrated in Scheme 13 (see S.A. Varia, S. Schuller, K.B. Sloan, and VJ. Stella, J. Pharm. Sci.. 73. 1068-1073 (1984)). Treatment of the parent compound with an aliphatic aldehyde, for example aqueous formaldehyde, provides the corresponding hydroxymethyl derivatives, which after conversion to the chloride with phosphorus trichloride, may be treated with silver dibenzyl phosphate. The resulting protected phosphates may be separated by conventional means, for example silica gel chromatography. The purified products may then be converted to the free phosphoric acids as depicted in Schemes 14 and 15, by treatment with a reducing agent such as hydrogen gas in the presence of pallidium on carbon. The object compounds of Formula I obtained according to the reactions as explained above may be isolated and purified in a conventional manner, for example, extraction, precipitation, fractional crystallization, recrystallization, chromatography, and the like. The compounds of the present invention are capable of forming salts with various inorganic and organic acids and bases and such salts are also within the scope of this invention. Examples of such acid addition salts include acetate, adipate, benzoate, benzenesulfonate, bisulfate, butyrate, citrate, camphorate, camphorsulfonate, ethane- sulfonate, fumarate, hemisulfate, heptanoate, hexanoate, hydrochloride, hydrobromide, hydroiodide, methanesulfonate, lactate, maleate, methanesulfonate, 2-naphthalenesulfonate, oxalate, pamoate, persulfate, picrate, pivalate, propionate, succinate, tartrate, tosylate, and undecanoate. Base salts include ammonium salts, alkali metal salts such as sodium, lithium and potassium salts, alkaline earth metal salts such as calcium and magnesium salts, salts with organic bases such as dicyclohexylamine salts, N-methyl-D-glucamine, and salts with amino acids such as arginine, lysine, ornithine and so forth. Also, the basic nitrogen-containing groups may be quaternized with such agents as: lower alkyl halides, such as methyl, ethyl, propyl, and butyl chloride, bromides and iodides; dialkyl sulfates like dimethyl, diethyl, dibutyl; diamyl sulfates; long chain halides such as decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides; aralkyl halides like benzyl bromide and others. The non-toxic physiologically acceptable salts are preferred, although other salts are also useful, such as in isolating or purifying the product. The salts may be formed by conventional means, such as by reacting the free base form of the product with one or more equivalents of the appropriate acid in a solvent or medium in which the salt is insoluble, or in a solvent such as water which is removed in vacuo or by freeze drying or by exchanging the anions of an existing salt for another anion on a suitable ion exchange resin. Although the reaction schemes described herein are reasonably general, it will be understood by those skilled in the art of organic synthesis that one or more functional groups present in a given compound of formula I may render the molecule incompatible with a particular synthetic sequence. In such a case an alternative route, an altered order of steps, or a strategy of protection and deprotection may be employed. In all cases the particular reaction conditions, including reagents, solvent, temperature, and time, should be chosen so that they are consistent with the nature of the functionality present in the molecule. As one skilled in the art will recognize, Examples 1 - 93 describe the prepartion of various parent compounds, whereas Examples 94 - 96 detail the prepartion of specific prodrugs of some of the parent compounds. Accordingly, the methodology presented in Examples 94 - 96 is readily adapted without undue experimentation to the preparation of the compounds of the present invention, including prodrugs of the parent compounds of Examples 1 - 93. The following examples are given for the puφose of illustrating the present invention and shall not be construed as being limitations on the scope or spirit of the instant invention. EXAMPLE 1 (+/-)-cc-Bromo-phenylacetaldehyde, 3,5-bis(trifluoro-methyl)benzyl acetal A solution of 2.50 g (10.2 mmol) of -bromo- phenylacetaldehyde, dimethyl acetal, 8.00 g (32.8 mmol) of 3,5- bis(trifluoromethyl)benzyl alcohol and 0.50 g (2.6 mmol) of p- toluenesulfonic acid monohydrate in 10 mL of toluene was stirred under vacuum (35 mmHg) at rt for 3 days. The reaction mixture was partitioned between 100 mL of ether and 50 mL of saturated aqueous sodium bicarbonate solution and the layers were separated. The organic layer was washed with 25 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate, and concentrated in vacuo. Flash chromatography on 200 g of silica gel using 9:1 v/v hexane/methylene chloride as the eluant afforded 5.41 g (81%) of the title compound as a solid, mp 79-82°C: lH NMR 4.47 and 4.62 (AB q, 2 H, J = 12.5), 4.78-4.93 (2 H), 5.09 and 5.21 (AB q, 2 H, J = 7.7), 7.31-7.44 (m, 7 H), 7.70 (app s, 1 H), 7.82 (app s, 1 H), 7.84 (app s 2 H); IR (thin film) 1363, 1278, 1174, 1130, 704, 682. Analysis Calcd for C26Hl7BrFi2θ2: C, 46.76; H, 2.23; Br, 11.64; F, 33.70. Found: C, 46.65; H, 2.56; Br, 11.94; F, 34.06. EXAMPLE 2 (+/-)-N-(2-Hydroxyethyl)-phenylglycinal, 3,5-bis-(trifluoromethyl)- benzyl acetal A solution of 1.50 g (2.2 mmol) of (+/-)- -bromo- phenylacetaldehyde, 3,5-bis(trifluoromethyl)-benzyl acetal (Example 1), 100 mg (0.67 mmol) of sodium iodide and 3 mL of ethanolamine in 6 mL of isopropanol was heated at reflux for 20 h. The solution was cooled and concentrated to ~25% the original volume in vacuo. The concentrated solution was partitioned between 50 mL of ether and 20 mL of 2 N aqueous sodium hydroxide solution and the layers were separated. The organic layer was washed with 20 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated in vacuo. Flash chromatography on 50 g of silica gel using 65:35 v/v ether/hexane as the elαant afforded 1.18 g (83%) of the title compound as an oil: lH NMR 2.66 (br s, 2 H), 2.61 and 2.68 (ddAB q, 2 H, JAB = 12.4, J2.61 = 6.8, 6.2, J2.68 = 6.2, 6.2), 3.57 and 3.66 (ddAB q, 2 H, JAB = 10.8, J3.57 = 6.2, 6.2), J3.66 = 6.8, 6.2), 4.02 (d, 1 H, J = 7.0), 4.37 and 4.64 (AB q, 2 H, J = 12.5), 4.80 and 4.87 (AB q, 2 H, J = 12.8), 4.87 (d, 1 H, J = 7.0), 7.31-7.40 (7 H), 7.73 (app s, 1 H), 7.81 (app s, 3 H); IR (neat) 3342, 1456, 1373, 1278, 1173, 1128, 704, 682; FAB-MS 650(M+1)+. Analysis Calcd for C28H23F12NO3: C, 51.78; H, 3.57; N, 2.16; F, 35.11. Found: C, 51.80; H, 3.67; N, 2.10; F, 35.41. EXAMPLE 3 (+/-)-N-(2-Hydroxyethyl)-N-(prop-2-enyl)-phenyl-glycinal, 3,5- bis(trifluoromethyl)benzyl acetal A mixture of 1.45 g (2.2 mmol) of (+/-)-N-(2- hydroxyethyl)-phenylglycinal, 3,5-bis-(trifluoromethyl)benzyl acetal (Example 2), 1.0 g (7.2 mmol) of potassium carbonate, 3.0 mL (35.0 mmol) of allyl bromide and 15 mL of ethanol was stirred at 60 °C for 20 h. The mixture was cooled, partitioned between 100 mL of ether and 25 mL of water and the layers were separated. The organic layer was dried over magnesium sulfate. The aqueous layer was extracted with 100 mL of ether; the ether extract was dried and combined with the original organic layer. The combined organic layers were concentrated in vacuo. Flash chromatography on 50 g of silica gel using 4:1 v/v hexane/ether as the eluant afforded 1.36 g (88%) of the title compound as an oil: lH NMR 2.40 (dt, 1 H, J = 13.2, 2.8), 2.93- 3.08 (3 H), 3.30 (ddt, 1 H, J = 12.0, 2.8, 1.6), 3.54 (br m, 2 H), 3.65 (dt, 1 H, J = 10.0, 2.8), 4.23 (d, 1 H, J = 8.4), 4.52 and 4.58 (AB q, 2 H, J = 12.4), 4.85 and 4.95 (AB q , 2 H, J = 12.4), 5.25 (d, 1 H, J = 9.6), 5.28 (d, 1 H, J = 16.4), 5.39 (d, 1 H, J = 8.4), 5.81 (m, 1 H), 7.24-7.40 (7 H), 7.68 (s 1 H), 7.83 (s, 1 H), 7.86 (s, 2 H); IR (neat) 3457, 1362, 1278, 1174, 1132, 1056, 759, 705, 682; FAB-MS 690(M+1)+. Analysis Calcd for C31 H27F12NO3 : C, 53.99; H, 3.95; N, 2.03; F, 33.07. Found: C, 54.11; H, 4.08; N, 1.78; F, 32.75. EXAMPLE 4 (+/-)-2-(3.5-Bis(trifluoromethyl)benzyloxy)-3-phenylmoφholine Step A: A solution of 850 mg (1.2 mmol) of (+/-)-N-(2- hydroxyethyl)-N-(prop-2-enyl)-phenyl-glycinal, 3,5-bis(trifluoro- methyl)benzyl acetal (Example 3) and 700 mg (3.7 mmol) of p- toluenesulfonic acid monohydrate in 15 mL of toluene was heated at reflux for 1.5 h. The reaction mixture was cooled and partitioned between 100 mL of ether and 25 mL of saturated aqueous sodium bicarbonate solution. The layers were separated; the organic layer was washed with 25 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate, and concentrated in vacuo. Flash chromatography on 30 g of silica gel using 50: 1 v/v hexane/ether as the eluant afforded 426 mg (78%) of the N-allyl moφholines which were used in the next step without further purification. Step B: A 50 mL 2-necked flask, equipped with a stopper and a short path distillation apparatus, was charged with a solution of the N- allyl moφholines (Example 4, Step A) (540 mg, 1.2 mmol)) and 80 mg (0.09 mmol) tris(triphenylphosphine)rhodium chloride (Wilkinson's catalyst) in 25 mL of 4: 1 v/v acetonitrile/water. The reaction mixture was heated to boiling and solvent was allowed to distill from the reaction mixture. The volume of the reaction mixture was maintained between 10 and 20 mL by adding solvent through the stoppered inlet. After 1 h and 4 h, the reaction was treated with additional 80 mg portions of the Wilkinson's catalyst. After 6 h, the reaction mixture cooled and partitioned between 75 mL of ether and 50 mL of water. The layers were separated and the organic layer was dried over magnesium sulfate. The aqueous layer was extracted with 75 mL of ether; the extract was dried and combined with the original organic layer. The combined organic layers were concentrated in vacuo. Flash chromatography on 35 g of silica gel using 1:1 v/v ether/hexane as the eluant afforded 200 mg of trans-isomer and 130 mg of a mixture of cis- and trans-isomers (68% total). Chromatography of the mixture on 8 g of silica gel using 4:1 v/v hexane/ether as the eluant afforded 64 mg of cis and 57 mg of a mixture of the cis- and trans-isomers of the title compound. For trans: lH NMR 2.03 (br s, 1 H), 2.94 (ddd, 1 H, J = 11.0, 2.5, 2.5), 3.08 (dt, 1 H, J = 11.0, 3.2), 3.71 (d, 1 H, J = 7.0), 3.83 (dt, 1 H, J = 11.2, 2.8), 4.05 (ddd, 1 H, J = 11.2, 3.2, 3.2), 4.43 (d, 1 H, J = 7.0), 4.53 and 4.88 (AB q, 2 H, J = 13.3), 7.26-7.45 (7 H), 7.70 (s, 1 H); IR (neat) 3333, 2859, 1456, 1374, 1278, 1173, 1131 , 1082, 757, 702, 682; FAB-MS 406(M+1)+. Analysis Calcd for C 19H 17F6NO2: C, 56.30; H, 4.23; N, 3.46; F, 28.12. Found: C, 56.39; H, 4.28; N, 3.36; F, 28.32. For cis: lH NMR 2.10 (br s, 1 H), 3.13 (dd, 1 H, J = 12.4, 3.0), 3.26 (dt, 1 H, J = 12.4, 3.6), 3.65 (dd, 1 H, J = 11.6, 3.6), 4.07 (dt, I H, J = 11.6, 3.0), 4.14 (d, 1 H, J = 2.4), 4.52 and 4.82 (AB q, 2 H, J = 13.6), 4.76 (d, 1 H, J = 2.4), 7.30-7.42 (6 H), 7.70 (s, 1 H), FAB-MS 406(M+1)+. EXAMPLE 5 (+/-)-2-(3,5-Bis(trifluoromethyl)benzyloxy)-3-phenyl-4-methylcarbox- amido moφholine A solution of 105 mg (0.26 mmol) of the trans-isomer of (+/-)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3-phenyl-moφholine (Example 4) and 0.09 mL (0.50 mmol) of N,N-diisopropylethylamine in 3 mL of acetonitrile was treated with 90 mg (0.50 mmol) of iodoacetamide and the resulting solution was stirred at rt for 16 h. The solution was concentrated in vacuo and the residue was partitioned between 20 mL of ethyl acetate and 10 mL of 0.5 N aqueous potassium hydrogen sulfate solution. The layers were separated; the organic layer was washed with 10 mL of 5% aqueous sodium thiosulfate solution, 10 mL of saturated aqueous sodium bicarbonate solution, 10 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated jn vacuo. Flash chromatography on 5 g of silica gel using 2:1 v/v ethyl acetate/hexane as the eluant afforded 99 mg (82%) of the trans-isomer of the title compound as an oil: lH NMR 2.56 (dt, 1 H, J = 3.2, 11.6), 2.67 and 3.16 (AB q, 2 H, J = 16.4), 2.96 (dt, 1 H, J = 12.0, 1.6), 3.30 (d, 1 H, J = 7.0), 3.86 (dt, 1 H, J = 3.2, 12.0), 4.08 (ddt, 1 H, J = 11.6, 3.2, 1.6), 4.48 and 4.84 (AB q, 2 H, J = 13.2), 4.49 (d, 1 H, J = 7.0), 5.98 (br s, 1 H), 6.83 (br s, 1 H), 7.33 (app s, 7 H), 7.70 (s, 1 H); IR (neat) 3445, 2838, 1682, 1278, 1173, 1132, 760, 704, 682; FAB-MS 463 (M+l)+. Analysis Calcd for C21 H20F6NO3 : C, 54.54; H, 4.36; N, 6.06; F, 24.65. Found: C, 54.54; H, 4.52; N, 5.61 ; F, 24.45. A similar experiment was carried out on 40 mg (0.99 mmol) of the cis-isomer of (+/-)-2-(3,5-bis-(trifluoromethyl)- benzyloxy)-3-phenyl-moφholine (Example 4) using 0.035 mL (0.2 mmol) of N,N-diisopropylethylamine and 37 mg (0.2 mmol) of iodoacetamide in the reaction. Work-up and flash chromatography afforded 30 mg (65%) of the cis-isomer of the title compound as an oil: lH NMR 2.54 and 3.04 (AB q , 2 H, J = 16.8), 2.63 (dt, 1 H, J = 3.6, 12.0), 3.04 (d, 1 H, J = 11.6), 3.65 (d, 1 H, J = 2.8), 3.71 (ddt, 1 H, J = 11.6, 3.2, 1.2), 4.21 (dt, 1 H, J = 11.6, 2.4), 4.44 and 4.89 (AB q , 2 H, J = 13.6), 4.71 (d, 1 H, J = 2.8), 5.86 (br s, 1 H), 7.15 (br s, 1 H), 7.27- 7.45 (7 H), 7.73 (s, 1 H); FAB-MS 463(M+1)+. EXAMPLE 6 (+/-)-2-(3,5-Bis(trifluoromethyl)benzyloxy)-3-phenyl-4-(methoxy- carbonylmethvPmorpholine A solution of 150 mg (0.37 mmol) of the trans-isomer of (+/-)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3 -phenyl moφholine (Example 4) and 0.18 mL (1.00 mmol) of N,N-diisopropyl-ethyl- amine in 2 mL of acetonitrile was treated with 0.095 mL (1.00 mmol) of methyl bromoacetate and the resulting solution was stirred at it for 20 h. The solution was concentrated in vacuo and the residue was partitioned between 20 mL of ethyl acetate and 5 mL of 0.5 N aqueous potassium hydrogen sulfate solution. The layers were separated; the organic layer was washed with 10 mL of saturated aqueous ς odium chloride solution, dried over magnesium sulfate and concentrated in vacuo. Flash chromatography on 10 g of silica gel using 4:1 v/v hexanes/ether as the eluant afforded 164 mg (93%) of the trans-isomer of the title compound as an oil: lH NMR 2.79 (dt, 1 H, J = 3.2, 11.2), 2.93 (dt, 1 H, J = 11.2, 1.6), 3.52 (d, 1 H, J = 7.2), 3.63 (s, 3 H), 3.92 (dt, 1 H, J = 2.8, 11.6), 4.04 (ddd, 1 H, J = 11.6, 3.2, 1.6), 4.45 and 4.84 (AB q, 2 H, J = 13.2), 4.46 (d, 1 H, J = 7.2), 7.31 - 7.38 (m, 6 H), 7.68 (s, 1 H); IR (neat) 2861, 1744, 1455, 1375, 1346, 1278, 1170, 887, 759, 704, 682; FAB-MS 478(M+1)+. Analysis Calcd for C22H21 F6NO4: C, 55.35; H, 4.43; N, 2.93; F, 23.88. Found: C, 55.74; H, 4.50; N, 2.79; F, 24.01. EXAMPLE 7 N-Methoxy-N-methyl-(N-t-butoxycarbonyl)-phenylglvcinamide A solution of 20.0 g (79.7 mmol) of (N-t-butoxycarbonyl)- phenylglycine in 150 mL of ethyl acetate at -10°C was treated with 8.8 mL (79.7 mmol) of 4-methylmoφholine. Isobutylchloroformate (10.3 mL, 79.7 mmol) was added dropwise over 10 minutes maintaining the temperature at -10°C; the resulting suspension was stirred cold for 15 min. The mixture was treated with 11.6 g (119.0 mmol) of N,0- Dimethyl-hydroxylamine • HCl. A second portion of 4-methyl- moφholine (13.0 mL, 119.0 mmol) was added and the reaction was stirred at -10°C for 15 min and at 25°C for 2 h. The reaction mixture was partitioned between 100 mL of ethyl acetate and 100 mL of 10% aqueous citric acid solution and the layers were separated. The organic layer was washed with 100 mL of saturated aqueous sodium bicarbonate solution, 100 mL of saturated aqueous ammonium chloride solution, dried over magnesium sulfate and concentrated in vacuo. Crystallization from hexanes at -20°C for 72 h afforded 8.0 g (34%) of the title compound as a solid: lH NMR 1.40 (s, 9 H), 3.20 (s, 3 H), 3.40 (s, 3 H), 5.80 (m, 2 H), 7.40 (m, 5 H). EXAMPLE 8 Diethyl (2-oxo-3-t-butoxycarbamido-3-phenyl)-propylphosphonate A solution of 7.45 mL (51.0 mmol) of diethyl methylphosphonate in tetrahydrofuran at -78°C was treated with 31.8 mL (51.0 mmol) of 1.6 M n-butyllithium in hexanes solution and the resulting mixture was stirred cold for 30 min. A solution of 4.0 g (14.0 mmol) of N-methoxy-N-methyl-(N-t-butoxycarbonyl)phenyl- glycinamide (Example 7) in 20 mL of tetrahydrofuran was added and the reaction was stirred at -78 °C for 15 min and at 25 °C for 15 min. The reaction was quenched with 150 mL of saturated aqueous ammonium chloride solution, diluted with 300 mL of ethyl acetate, and the layers were separated. The organic layer was dried over magnesium sulfate and concentrated in vacuo. Flash chromatography on silica gel using 7:3 v/v then 4:1 v/v ethyl acetate/hexanes as the eluant afforded 4.8 g (92%) of the title compound as an oil: lH NMR 1.20- 1.42 (15 H), 2.84 (dd, 1 H), 3.20 (dd, 1 H), 4.00-4.20 (m, 4 H), 5.50 (d, 1 H), 5.94 (br s, 1 H), 7.32 (m, 5 H). EXAMPLE 9 N-t-Butoxycarbonyl-l -phenyl-2-oxo-4-(3,5-bis(tri-fluoromethyl)- phenyl)-but-3-enamine A solution of 4.80 g (12.5 mmol) of diethyl (2-oxo-3-t- butoxycarbamido-3-phenyl)propylphosphonate (Example 8) in 20 mL of THF was added dropwise to a suspension of 1.05 g (26.3 mmol, 60% dispersion in mineral oil) of sodium hydride in 30 mL of tetrahydrofuran at 0°C. After 15 min, 2.06 mL (12.5 mmol) of 3,5- bis(trifluoromethyl)benzaldehyde was slowly added and the resulting mixture was stirrred cold for 15 min. The reaction was quenched with 50 mL of saturated aqueous ammonium chloride solution, diluted with 50 mL of ethyl acetate, and the layers were separated. The organic layer was dried over magnesium sulfate and concentrated in vacuo. Flash chromatography on silica gel using 19:1 v/v, then 9:1 v/v ethyl acetate/petroleum ether as the eluant afforded 3.30 g (56%) of the title compound as a solid: lH NMR 1.40 (s, 9 H), 5.38 (d, 1 H), 5.90 (d, 1 H), 6.80 (d, 1 H), 7.39 (m, 5 H), 7.70 (s, 1 H), 7.84 (s, 3 H). EXAMPLE 10 l-Phenyl-2-hydroxy-4-(3,5-bis(trifluoromethyl)phenyl)-but-3-enamine • HCl A solution of 1.00 g ( 2.1 mmol) of N-t-butoxycarbonyl-1- phenyl-2-oxo-4-(3,5-bis(trifluoromethyl)phenyl)-but-3-enamine (Example 8) in 30 mL of methanol at 0°C was treated with 241 mg (6.3 mmol) of sodium borohydride. After 30 min, the reaction was quenched with 50 mL of water and concentrated in vacuo to remove the methanol. The mixture was partitioned between 100 mL of ethyl acetate and 50 mL of water and the layers were separated. The organic layer was dried over magnesium sulfate and concentrated in vacuo. Crystallization from ether/hexanes afforded 680 mg (68%) of the title compound as a 5:1 mixture of diastereomers (each protected as the t- butylcarbamate): H NMR (* indicates the resonances of the minor diastereomer) 1.40 (s, 9 H), 4.60 (dd, 1 H), 4.90 (br s, 1 H), 5.20 (br d, 1 H), 6.30 (dd, 1 H), 6.40 (dd. 1 H*), 6.70 (dd, 1 H), 6.80 (dd, 1 H*), 7.40 (m, 5 H), 7.80 (m, 3 H). A solution of BOC-protected title compound in methanol (saturated with HCl) was allowed to stand for 72 h. The solution was concentrated in vacuo. Recrystallization of the resulting solid from ether/hexane afforded 500 mg (80%) of the title compound • HCl as a solid: lH NMR 4.20 (br s, 1 H), 4.40 (d, 1 H), 6.20 (dd, 1 H), 6.60 (dd, 1 H), 7.30 (m 5 H), 7.80 (m, 3 H). The title compound • HCl was dissolved in ethyl acetate and 1 N aqueous sodium hydroxide solution. The layers were separated; the organic layer was dried over magnesium sulfate and concentrated in vacuo to afford the title compound as the free base. EXAMPLE 11 2-(2-(3,5-Bis(trifluoromethyl)phenyl)ethenyl)-3-phenyl-5-oxo- morpholine A solution of 1.95 g (5.2 mmol) of 1 -phenyl-2-hydroxy-4- (3,5-bis(trifluoromethyl)phenyl)-but-3-enamine (Example 10) in 20 mL of toluene was added to a suspension of 250 mg (6.2 mmol, 60% dispersion in mineral oil) of sodium hydride in 30 mL of toluene and the resulting mixture was stirred at rt for 15 min. A solution of 0.60 mL (1.15 mol) of ethyl chloroacetate in 5 mL of toluene was slowly added and the resulting mixture was heated at reflux for 3 h. The reaction was cooled, quenched with 50 mL of saturated aqueous ammonium chloride solution, diluted with 50 mL of ethyl acetate and the layers were separated. The organic layer was dried over magnesium sulfate and concentrated in vacuo. Flash chromatography using ethyl acetate/hexanes (4:1 v/v, then 3:1 v/v, then 1 :1 v/v) then ethyl acetate as the eluant afforded 300 mg of trans-title compound and 800 mg of cis-title compound (55% total), both as solids. For the cis- isomer: IH NMR 1.20-1.40 (m, 1 H), 1.50-1.62 (m, 1 H), 2.60-2.98 (m, 2 H), 3.86 (dt, 1 H), 4.24 (d, 1 H), 4.34 (dd, 1 H), 4.45 (d, 1 H), 6.40 (br s, 1 H), 7.24 (m, 2 H), 7.40 (m, 3 H), 7.50 (s, 2 H), 7.70 (s, 1 H). EXAMPLE 12 3-Phenyl-2-(2-(3.5-bis(trifluoromethyl)phenyl)ethyl)-moφholine A solution of 95 mg (0.23 mmol) of 2-(2-(3,5- bis(trifluoromethyl)ρhenyl)ethenyl)-3-phenyl-5-oxo-moφholine (Example 11) in 10 mL of 1 :1 v/v ethanol/ ethyl acetate was treated with 10 mg of palladium hydroxide and the resulting mixture was stirred under an atmosphere of hydrogen for 2 h. The catalyst was filtered and the filtrate was concentrated in vacuo. The crude product was used directly without further purification. A solution of 65 mg of the crude moφholinone was dissolved in 10 mL of tetrahydrofuran was treated with 0.84 mL of 1 M borane«tetrahydrofuran complex solution in tetrahydrofuran and the resulting solution was heated at reflux for 16 h. The reaction was quenched by adding 10 mL of methanol and 70 mg of potassium carbonate and heating the resulting mixture at reflux for 3 h. All volatiles were removed in vacuo and the residue was partitioned between 20 mL of ethyl acetate and 10 mL of saturated ammonium chloride solution. The organic layer was separated, dried over sodium carbonate, and concentrated in vacuo. The residue was dissolved in saturated HCl in methanol and concentrated in vacuo. The residue was triturated with ether; the resulting solid was filtered and dried to afford 32 mg (46%) of the title compound • HCl, mp 114-116°C: lH NMR 1.42 (m, 1 H), 1.66-1.84 (m, 1 H), 2.70-2.94 (m, 2 H), 3.00 (m, 1 H), 3.30-3.46 (m, 1 H), 3.80-3.94 (m, 2 H), 4.10 (m, 1 H), 4.20 (d, 1 H), 7.40 (m, 3 H), 7.64 (m, 5 H); CI-MS 402(M+1)+. EXAMPLE 13 N-Benzyl-(S)-phenylglvcine A solution of 1.51 g (10.0 mmol) of (S)-phenylglycine in 5 mL of 2 N aqueous sodium hydroxide solution was treated with 1.0 mL (10.0 mmol) of benzaldehyde and stirred at room temperature for 20 minutes. The solution was diluted with 5 mL of methanol, cooled to 0°C, and carefully treated with 200 mg (5.3 mmol) of sodium borohydride. The cooling bath was removed and the reaction mixture was stirred at room temperature for 1.5 hours. The reaction was diluted with 20 mL of water and extracted with 2x25 mL of methylene chloride. The aqueous layer was acidified with concentrated hydrochloric acid to pH 6 and the solid that precipitated was filtered, washed with 50 mL of water, 50 mL of 1:1 v/v methanol/ethyl ether and 50 mL of ether, and dried to afford 1.83 g (76%) of product, mp 230-232°C. Analysis Calcd for C 15H 15NO2: C, 74.66; H, 6.27; N, 5.81. Found: C, 74.17; H, 6.19; N, 5.86. EXAMPLE 14 3-(S)-Phenyl-4-benzyl-2-moφholinone A mixture of 4.00 g (16.6 mmol) of N-benzyl-(S)- phenylglycine (from Example 13), 5.00 g (36.0 mmol) of potassium carbonate, 10.0 mL of 1 ,2-dibromoethane and 25 mL of N,N- dimethylformamide was stirred at 100°C for 20 hours. The mixture was cooled and partitioned between 200 mL of ethyl ether and 100 mL of water. The layers were separated and the organic layer was washed with 3x50 mL of water, dried over magnesium sulfate and concentrated in vacuo. The residue was purified by flash chromatography on 125 g of silica gel eluting with 9:1 v/v, then 4:1 v/v hexanes/ethyl ether to afford 2.41 g (54%) of the product as a solid, mp 98-100°C. Mass Spectrum (FAB): m/Z 268 (M+H, 100%). lH NMR (CDC13, 200 MHz, ppm): δ 2.54-2.68 (m, IH), 2.96 (dt, J= 12.8, 2.8, IH), 3.14 (d, J= 13.3, IH), 3.75 (d, J= 13.3, IH), 4.23 (s, IH), 4.29-4.37 (m, IH), 4.53 (dt, J= 3.2, 11.0), 7.20-7.56 (m, 10H). Analysis Calcd for C 17H 17NO2: C, 76.38; H, 6.41; N, 5.24. Found: C, 76.06; H, 6.40; N, 5.78. EXAMPLE 15 2-(S)-(3.5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenylmoφholine Step A: 3,5-Bis(trifluoromethyl)benzyl alcohol, trifluoromethane- sulfonate ester A solution of 1.00 g (4.1 mmole) of 3,5-bis(trifluoro- methyl)benzyl alcohol and 1.05 g (5.12 mmole) of 2,6-di-t-butyl-4- methylpyridine in 45 mL of dry carbon tetrachloride under a nitrogen atmosphere was treated with 0.74 mL (4.38 mmole) of trifluoro- methanesulfonic anhydride at room temperature. A white precipitate formed shortly after the addition of the anhydride. After 90 min, the slurry was filtered under nitrogen with a Schlenk filter, and the filtrate was concentrated in vacuo. The residue, which was a two-phase oil, was dissolved under nitrogen in 10 mL of dry toluene. The resulting clear solution was used immediately in Step B below. Step B: 4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)benz-yloxy)-3-(S)- phenylmorpholine A solution of 0.500 g (1.87 mmole) of N-benzyl-3-(S)- phenylmoφholin-2-one (from Example 14) in 10 mL of dry THF was cooled to -75 °C under nitrogen and was treated dropwise with 2.06 mL (2.06 mmole) of a 1M solution of lithium tri(sec-butyl)-borohydride (L-Selectride®) in THF. After stirring the solution at -75 °C for 30 min, a solution of 3,5-bis(trifluoromethyl)benzyl alcohol, trifluoro- methanesulfonate ester in toluene was added by cannula so that the internal temperature was maintained below -60°C. The resulting solution was stirred at -75°C for 1 hr and then between -38°C and -50°C for 2 hr. The solution was then poured into a mixture of 25 mL of ethyl acetate and 20 mL of saturated aqueous sodium bicarbonate, and the layers were separated. The aqueous phase was extracted with 2x30 mL of ethyl acetate, the combined organic layers were dried over sodium sulfate, the mixture was filtered and the filtrate concentrated in vacuo. The residue was purified by flash chromatography on 130 g of silica eluting with 2 L of 100:5 hexanes:ethyl acetate to give 0.68 g (73%) of an oil, which by lH NMR is a 20:1 mixture of cis:trans moφholines. lH NMR (CDC13, 400 MHz, ppm): δ major (cis) isomer: 2.37 (td, J= 12, 3.6, IH), 2.86 (app t, J= 13, 2H), 3.57 (d, J= 2.6, IH), 3.63 (dq, J= 11.3, 1,6, IH), 3.89 (d, J= 13.3, IH), 4.12 (td, J= 11.6, 2.4, IH), 4.40 (d, J= 13.6, IH), 4.69 (d, J= 2.9, IH), 4.77 (d, J= 13.6), 7.2-7.4 (m, 8H), 7.43 (s, 2H), 7.55 (br d, 2H), 7.69 (s, IH). Step C: 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl- moφholine A mixture of 0.68 g (1.37 mmole) of 4-benzyl-2-(S)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(S)-phenylmoφholine and 280 mg of 10% Pd/C in 36 mL of 97:3 ethanokwater was stirred under one atmosphere of hydrogen for 15 hr. The mixture was filtered through Celite, the filter cake was washed generously with ethanol, and the filtrated was concentrated in vacuo. The residue was purified by flash chromatography on 68 g of silica eluting with 1L of 33:67 hexanes: diethyl ether, then 1L of 25:75 hexanes: diethyl ether to give 0.443 g (80%) of an oil, which by lH NMR was pure cis moφholine. lH NMR (CDC13, 400 MHz, ppm): δ 1.8 (br s, IH), 3.10 (dd, J= 12.5, 2.9, IH), 3.24 (td, J= 12.2, 3.6, IH), 3.62 (dd, J= 11.3, 2.5, IH), 4.04 (td, J= 11.7, 3, IH), 4.11 (d, J= 2.4, IH), 4.49 (d, J= 13.5, IH), 4.74 (d, J= 2.5, IH), 4.80 (d, J= 13.3, IH), 7.25-7.40 (m, 5H), 7.40 (s, 2H), 7.68 (s, IH). Analysis Calcd for C 19H 17F6NO2: C, 56.30; H, 4.23; N, 3.46; F, 28.12. Found: C, 56.20; H, 4.29; N, 3.34; F, 27.94. EXAMPLE 16 2(R)-(3.5-Bis(trifluoromethyl)benzyloxy)-3(R)-phenyl-moφholine The title compound was prepared from (R)-phenylglycine employing the procedures of Examples 13, 14 and 15. EXAMPLE 17 4-(3-(l,2,4-Triazolo)methyl)-2-(S)-(3,5-bis(trifluoro-methyl)- benzyloxy)-3-(S)-phenylmorpholine Step A: N-Formyl-2-chloroacetamidrazone A solution of 5 g (66.2 mmole) of chloroacetonitrile in 30 mL of dry methanol was cooled to 0°C under nitrogen and was treated with 0.1 g (1.8 mmole) of sodium methoxide. The mixture was allowed to warm to room temperature and was stirred for 30 min, and 0.106 mL (1.8 mmole) of acetic acid was added. To the resulting mixture was then added 3.9 g (64.9 mmole) of formic hydrazide, and the material was stirred for 30 min. The reaction mixture was concentrated in vacuo to a solid, and was used as such in Step B below. Step B: 4-(3-(l ,2,4-Triazolo)methyl)-2-(S)-(3,5-bis-(trifluoro- methyl)benzyloxy)-3-(S)-phenyl-moφholine A solution of 0.295g (0.73 mmole) of 2-(S)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(S)-phenylmoφholine (from Example 15) in 10 mL of dry DMF was treated with 0.302g (2.18 mmole) of anhydrous potassium carbonate and then 0.168g (1.24 mmole) of N- formyl-2-chloroacetamidrazone (from Example 17, Step A) and the suspension was stirred at 60°C for 4 hr. The mixture was then heated to 120°C for 4.5 hr. After cooling, the reaction was diluted with 80 mL of ethyl acetate and the organic layer was washed with 3x20 mL of water. The organic layer was dried over magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by flash chromatography on 67 g of silica eluting with 1.5 L of 100:2 methylene chloride :methanol to give 0.22 g of a yellow solid, which was recrystallized from hexanes/methylene chloride to give 0.213g (60%) of a white crystalline solid, mp 134-135°C. Mass Spectrum (FAB): m/Z 487 (M+H, 100%), 259 (35%), 243 (65%), 227 (40%), 174 (25%). lH NMR (CDC13, 400 MHz, ppm): δ 2.67 (td, J= 11.9, 3.4, IH), 2.90 (br d, J= 11.7, IH), 3.43 (d, J= 15.2, IH), 3.66 (app dd, J= 13, 1.9, 2H), 3.88 (d, J= 15.1 , IH), 4.17 (td, J= 11.7, 2.3, IH), 4.42 (d, J= 13.5, IH), 4.69 (d, J= 2.6, IH), 4.77 (d, J= 13.5, IH), 7.30-7.50 (m, 7H), 7.70 (s, IH), 7.94 (s, IH). EXAMPLE 18 4-(3-(5-Oxo-lH,4H-l,2,4-triazolo)methyl)-2-(S)-(3,5-bis(trifluoro- methyl) benzyloxy)-3-(S)-phenylmoφholine Step A: N-Methylcarboxy-2-chloroacetamidrazone A solution of 5.0 g (66.2 mmol) of chloroacetonitrile in 35 mL of dry methanol was cooled to 0°C and was treated with 0.105 g (1.9 mmol) of sodium methoxide. The ice-bath was removed and the mixture was alowed to stir at room temperature for 30 minutes. To the reaction was then added 0.110 mL (1.9 mmol) of acetic acid and then 5.8 g (64.9 mmol) of methyl hydrazinecarboxylate. After stirring 30 minutes at room temperature, the suspension was concentrated in vacuo. and placed on the high-vac line overnight, to give 10.5 g (98%) of a yellow powder, which was employed in Step C below. IH NMR (CD3OD, 400 MHz, ppm): δ 3.71 (s, 3H), 4.06 (s, 2H). Step B: 4-(2-(N-Methylcarboxy-acetamidrazono)-2-(S)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(S)-phenylmoφholine A solution of 2.30 g (5.7 mmol) of 2-(S)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(S)-phenylmoφholine (from Example 15), 1.13 g (6.8 mmol) of N-methylcarboxy-2-chloroacetamidrazone (from Step A), and 1.50 mL (8.6 mmol) N,N-diisopropylethylamine in 25 mL of acetonitrile was stirred at room temperature for 20 hours. The product, which had preciptated, was filtered, washed with 5 mL of ice cold acetonitrile and dried to give 1.83 g of a white solid. The filtrate was concentrated in vacuo and the residue was partitioned between 50 mL of methylene chloride and 20 mL of water. The layers were separated and the organic layer was dried over magnesium sulfate. The aqueous layer was extracted with 50 mL of methylene chloride; the extract was dried, combined with the original organic layer, and the combined organics were concentrated in vacuo. The residue was purified by flash chromatography on 30 g of silica gel eluting with 50:1 :0.1 v/v/v methylene chloride/methanol/ammonium hydroxide to afford an additional 1.09 g of product (96% total). Mass Spectrum (FAB): m/Z 535 (M+H, 100%), 462 (16%), 291 (30%), 226 (35%), 173 (25%). lH NMR (CDCI3, 400 MHz, ppm): δ 2.53 (dt, J= 3.5, 12.2, IH), 2.59 (d, J= 14.6, IH), 2.94 (d, J= 11.8, IH), 3.37 (d, J= 14.6, IH), 3.58 (d, J= 2.8), IH), 3.62-3.72 (m, IH), 3.75 (s, 3H), 4.16 (dt, J= 2.2, 11.8, 1H), 4.44 (d, J= 13.2, IH), 4.70 (d, J= 2.8, IH), 4.79 (d, J= 13.2), 5.55 (br s, 2H), 7.30-7.46 (m, 7H), 7.72 (s, IH). Step C: 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(3-(5-oxo- 1 H.4H- 1.2.4-triazolo)methyl)-3-(S)-phenylmoφholine A solution of 2.89 g (5.4 mmol) of 4-(2-(N-methyl- carboxyacetamidrazono)-2-(S)-(3,5-bis(trifluoromethyl) benzyloxy)-3- (S)-phenylmoφholine (from Step B) in 36 mL of xylenes was heated at reflux for 1.5 hours. The solution was cooled and concentrated in vacuo. The residue was taken up in 50 mL of 3:1 v/v hexanes/ethyl acetate which caused crystallization of the product. The product was filtered and dried to afford 1.85 g of a solid. Recrystallization of the solid from 30 mL of 4:1 v/v hexanes/ethyl acetate afforded 1.19 g of pure product as a white solid, mp= 156-157°C. All of the crystallization liquors were combined and concentrated in vacuo. The residue was purified by flash chromatography on 30 g of silica gel eluting with 50:1:0.1 v/v/v methylene chloride/methanol/ammonium hydroxide to afford an additional 0.69 g of a solid. Three recrystallizations from 20 mL of 4:1 v/v hexanes/ethyl acetate afforded an additional 0.39 g of pure product as a white solid (58% total). Mass Spectrum (FAB): m/Z 503 (M+H), 259 (55%), 226 (40%), 160 (30%). lH NMR (CDC13, 400 MHz, ppm): δ 2.57 (app t, J= 9.6, IH), 2.87-2.97 (m, 2H), 3.58-3.71 (m, 3H), 4.18 (app t, J= 10.4, IH), 4.46 (d, J= 13.6), 4.68 (d, J= 2.8, IH), 4.85 (d, J= 13.6, IH), 7.30-7.45 (m, 7H), 7.64 (s, IH), 10.40 (br s, IH), 10.73 (br s, IH). EXAMPLE 19 N-(2-(R)-Hydroxypropyl)-ρhenylglycinal, 3,5-bis(tri-fluoromethyl)- benzyl acetal A mixture of 1.00 g (1.5 mmol) of (+/-)-a- bromo- phenylacetaldehyde, 3,5-bis(trifluoromethyl)-benzyl acetal (from Example 12), 1.25 mL of (R)-l-amino-2-proρanol, 225 mg (1.5 mmol) of sodium iodide, and 3.75 mL of isopropanol was heated at reflux for 20 h. The solution was cooled and concentrated to ~25% the original volume in vacuo. The concentrated solution was partitioned between 50 mL of ether and 20 mL of 2 N aqueous sodium hydroxide solution and the layers were separated. The organic layer was washed with 20 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated in vacuo. Flash chromatography on 50 g of silica gel using 65:35 v/v ether/hexane as the eluant afforded 948 mg (95%) of the product as a 1 :1 mixture of inseparable diastereomers. Mass Spectrum (FAB): m/Z 664 (M+H, 25%), 420 (20%), 226 (100%). EXAMPLE 20 N-(2-(S)-Hydroxypropyl)-phenylglycinal, 3,5-bis(tri-fluoromethyl)- benzyl acetal Substitution of (S)-l-amino-2-propanol for (R)-l-amino-2- propanol in an experiment identical to the preceding example afforded 940 mg (95%) of the product as a 1:1 mixture of diastereomers. EXAMPLE 21 N-(2-(R)-Hydroxypropyl)-N-(prop-2-enyl)-(R)-phenyl-glycinal, 3,5- bis(trifluoromethyl)benzyl acetal and N-(2-(R)-Hydroxypropyl)-N- (prop-2-enyl)-(S)-ρhenyl-glycinal, 3,5-bis(trifluoromethyl)benzyl acetal A mixture of 933 mg (1.40 mmol) of N-(2-(R)- hydroxy- propyl)-phenylglycinal, 3,5-bis(trifluoromethyl)-benzyl acetal (from Example 19), 1 mL of allyl bromide, 600 mg (4.3 mmol) of potassium carbonate, and 5 mL of ethanol was stirred at 60°C for 20 hours. The mixture was cooled, partitioned between 100 mL of ethyl ether and 25 mL of water and the layers were separated. Flash chromatography on 50 g of silica gel using 20:1 v/v ether/hexanes as the eluant afforded 380 mg of the (R,R)-amino alcohol (Rf = 0.72 with 3:2 v/v ether/hexanes as the eluant), 220 mg of the (R,S)-amino alcohol (Rf = 0.62 with 3:2 v/v ether/hexanes as the eluant), and 285 mg of a mixture of the disastereomeric amino alcohols. For the (R.R)-amino alcohol: Mass Spectrum (FAB): m/Z 704(M+H). IR (neat) 3476, 2932, 1624, 1454, 1361, 1278, 1175, 1132, 760, 704, 682. lH NMR (CDC13, 400 MHz, ppm) 1.12 (d, 3 H, J = 6.4), 2.19 and 2.62 (dAB q, 2 H, J AB = 13.0, J 2.19 = 2.3, J 2.62 = 10.4), 2.97 (dd, 1 H, J = 14.0, 8.8), 3.25 - 3.30 (m, 1 H), 3.76 (s, 1 H), 3.77 - 3.85 (m, 1 H), 4.21 (d, 1 H, J = 8.8), 4.49 and 4.55 (AB q, 2 H, J = 12.4), 4.86 and 4.92 (AB q, 2 H, J = 12.4), 5.27 - 5.33 (m, 2 H), 5.39 (d, 1 H, J = 8.8), 5.79 - 5.89 (m, 1 H), 7.21 - 7.26 (m, 4 H), 7.35 - 7.40 (m, 3 H), 7.67 (s, 1 H), 7.81 (s, 1 H), 7.85 (s, 2 H). Analysis Calcd for C32H29F 12NO3 : C, 54.63; H, 4.15; N, 1.99; F, 32.41. Found: C, 54.72; H, 3.94; N, 1.95; F, 32.17. For the (R.S)-amino alcohol: Mass Spectrum (FAB): m/Z 704(M+1). IR (neat) 3451, 2931, 1624, 1454, 1362, 1277, 704, 683. lH NMR (CDC13, 400 MHz, ppm) 1.09 (d, 3 H, J = 6.0), 2.48 and 2.71 (dAB q, 2 H, J AB = 13.2, J 2.48 = 9.6, J 2.62 = 3.6), 3.05 (dd, 1 H, J = 14.4, 6.8), 3.34 - 3.39 (m, 1 H), 3.35 (s, 1 H), 3.76 - 3.81 (m, 1 H), 4.21 (d, 1 H, J = 8.4), 4.50 and 4.54 (AB q, 2 H, J = 12.8), 4.86 and 4.96 (AB q, 2 H, J = 12.4), 5.10 - 5.17 (m, 2 H), 5.39 (d, 1 H, J = 8.4), 5.68 - 5.78 (m, 1 H), 7.23 - 7.32 (m, 4 H), 7.34 - 7.39 (m, 3 H), 7.69 (s, 1 H), 7.83 (s, 1 H), 7.86 (s, 2 H). Analysis Calcd for C32H29F12NO3 : C, 54.63; H, 4.15; N, 1.99; F, 32.41. Found: C, 54.80; H, 4.16; N, 1.90; F, 32.36. EXAMPLE 22 N-(2-(S)-Hydroxyproρyl)-N-(prop-2-enyl)-(S)-phenyl-glycinal, 3,5-bis(trifluoromethyl)benzyl acetal and N-(2-(S)-Hydroxypropyl)-N- (prop-2-enyl)-(R)-phenyl-glycinal, 3,5-bis(trifluoromethyl)benzyl acetal Substitution of 880 mg (1.33 mmol) of N-(2-(S)-hydroxy- propyl)-phenylglycinal, 3,5-bis(trifluoro-methyl)benzyl acetal (Example 20) for the N-(2-(R)-hydroxypropyl)-phenylglycinal, 3,5-bis(trifluoro- methyl)benzyl acetal in the procedures of the preceding example afforded 281 mg of the (S,S)-amino alcohol (Rf = 0.72 with 3:2 v/v ether/hexanes as the eluant), 367 mg of the (S,R)-amino alcohol (Rf = 0.62 with 3:2 v/v ether/hexanes as the eluant), and 197 mg of a mixture of the disastereomeric amino alcohols. EXAMPLE 23 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(R)-methyl moφholine and 2-(S)-(3,5-Bis-(trifluoromethyl)benzyloxy)-3-(R)- phenyl-6-(R)-methyl moφholine Step A: 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-4- (2-propenyl)-6-(R)-methyl moφholine and 2-(S)-(3,5- bis(trifluoro-methyl)-benzyloxy)-3-(R)-phenyl-4-(2-pro- penyl)-6-(R)-methyl moφholine A solution of 355 mg (0.50 mmol) of N-(2-(R)-hydroxy- propyl)-N-(2-proρenyl)-(R)-phenylglycinal, 3,5-bis(trifluoromethyl)- benzyl acetal (from Example 21) and 285 mg (1.5 mmol) of p- toluensulfonic acid monohydrate in 5 mL of toluene was heated at reflux for 40 min. The solution was cooled and partitioned between 40 mL of ether and 15 mL of saturated aqueous sodium bicarbonate solution. The layers were separated; the organic layer was washed with 10 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate, and concentrated in vacuo. Flash chromatography on 10 g of silica gel using 19:1 v/v hexanes/ether as the eluant afforded 122 mg of (2R,3R,6R) product (Rf = 0.53 with 4:1 v/v hexanes/ether as the eluant) and 62 mg of the (2S,3R,6R) product (Rf = 0.23 with 4:1 v/v hexanes/ether as the eluant). For the (2R.3R.6R) product: Mass Spectrum (FAB): m/Z 460 (M+H, 65%) lH NMR (CDC13, 400 MHz, ppm) 1.35 (d. 3 H, J = 6.4), 2.53 and 2.63 (dAB q, 2 H, J AB = 12.0, J 2.53 = 3.2, J 2.63 = 6.8), 2.83 - 2.96 (m, 2 H), 3.60 (d, 1 H, J = 4.0), 4.27 - 4.32 (m, 1 H), 4.57 and 4.84 (AB q, 2 H, J = 13.2), 4.87 (d, 1 H, J = 4.0), 5.08 - 5.13 (m, 2 H), 5.76 - 5.86 (m, 1 H), 7.31 - 7.37 (m, 3 H), 7.50 - 7.52 (m, 2 H), 7.58 (s, 2 H), 7.71 (s, 1 H). For the (2S.3R.6R) product: Mass Spectrum (FAB): m/Z 460 (M+H, 65%) lH NMR (CDCI3, 400 MHz, ppm) 1.37 (d. 3 H, J = 6.8), 2.48 - 2.50 (m, 2 H), 2.74 and 3.01 (dtAB q, 2 H, J = 6.4, 1.2, 12.4) 3.84 (d, 1 H, J = 3.6), 3.92 - 3.99 (m, 1 H), 4.70 and 4.93 (AB q, 2 H, J = 13.6), 4.97 (d, 1 H, J = 3.6), 5.08 - 5.14 (m, 2 H), 5.74 - 5.84 (m, 1 H), 7.28 - 7.36 (rh, 3 H), 7.43 - 7.46 (m, 2 H), 7.64 (s, 2 H), 7.75 (s, 1 H). Step B: 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6- (R)-methyl moφholine A solution of 115 mg (0.25 mmol) of the 2-(R)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-4-(2-propenyl)-6-(R)- methyl moφholine (from Example 23, Step A) and 230 mg (0.25 mmol) of tris(triphenylphosphine)rhodium chloride in 15 mL of 4:1 v/v acetonitrile/water was heated at reflux for 30 min. The reaction was cooled and partitioned between 50 mL of ethyl acetate and 15 mL of water. The layers were separated and the organic layer was dried over magnesium sulfate. The aqueous layer was extracted with 2 x 25 mL of ethyl acetate; the extracts were dried and combined with the original organic layer. The combined organics were concentrated m vacuo. The residue was filtered through a pad of silica gel (~ 20 g) using 2:1 v/v ether/hexanes as the solvent. The filtrate was concentrated; flash chromatography on 5 g of silica gel using 17:3 v/v hexanes/ether as the eluant afforded 67 mg (64%) of 2-(R)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(R)-methyl moφholine as an oil. Mass Spectrum (FAB): m/Z 420 (M+H, 90%) lH NMR (CDC13, 400 MHz, ppm) 1.21 (d, 3 H, J = 6.4), 2.02 (br s, 1 H), 2.67 and 2.77 (dAB q, 2 H, J AB = 13.2, J 2.67 = 8.8, J 2.77 = 3.2), 3.89 (d, 1 H, J = 2.4), 4.07 - 4.15 (m, 1 H), 4.68 and 4.90 (AB q, 2 H, J = 12.8), 5.03 (d, 1 H, J = 2.4), 7.28 - 7.38 (m, 3 H), 7.51 - 7.53 (m, 2 H), 7.77 (s, 2 H), 7.79 (s, 1 H). Step C: 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6- (R)-methyl moφholine A similar reaction was carried out using 55 mg (0.12 mmol) of 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-4-(2- propenyl)-6-(R)-methyl moφholine (from Example 23, Step A) and 111 mg (0.12 mmol) of tris(triphenylphosphine)rhodium chloride in 12 mL of 4:1 v/v acetonitrile/water. Flash chromatography on 4 g of silica gel using 50:1 v/v methylene chloride/acetonitrile as the eluant afforded 14 mg (28%) of 2-(S)-(3,5-bis(trifluoromethyl)-benzyloxy)-3- (R)-phenyl-6-(R)-methyl moφholine as an oil. Mass Spectrum (FAB): m/Z 420 (M+H, 90%) lH NMR (CDCI3, 400 MHz, ppm) 1.39 (d, 3 H, J = 6.8), 1.92 (br s, 1 H), 2.84 and 2.95 (dAB q, 2 H, J AB = 12.8, J 2.84 = 6.4, J 2.95 = 3.6), 3.93 - 4.00 (m, 1 H), 4.07 (d, 1 H, J = 2.8), 4.68 and 4.95 (AB q, 2 H, J = 13.2), 4.93 (d, 1 H, J = 2.8), 7.28 - 7.37 (m, 3 H), 7.48 - 7.52 (m, 2 H), 7.55 (s, 2 H), 7.72 (s, 1 H). EXAMPLE 24 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-ρhenyl-6-(S)-methyl moφholine and 2-(R)-(3,5-Bis-(trifluoromethyl)benzyloxy)-3-(S)- phenyl-6-(S)-methyl moφholine Substitution of 350 mg of N-(2-(S)-hydroxy-propyl)-N-(2- propenyl)-(S)-phenylglycinal, 3,5-bis-(trifluoromethyl)benzyl acetal (from Example 22) for N-(2-(R)-hydroxypropyl)-N-(2-propenyl)-(R)- phenyl-glycinal, 3,5-bis(trifluoromethyl)benzyl acetal in an experiment similar to the preceding example afforded 50 mg of 2-(S)-(3,5- bis(trifluoromethyl)be_nzyloxy)-3-(S)-phenyl-6-(.S)-methyl moφholine and 14 mg of 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6- (S)-methyl moφholine. EXAMPLE 25 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(R)-methyl moφholine and 2-(S)-(3,5-Bis-(trifluoromethyl)benzyloxy)-3-(S)- phenyl-6-(R)-methyl moφholine Step A: 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-4- (2-propenyl)-6-(R)-methyl moφholine and 2-(S)-(3,5- bis(trifluoro-methyl)-benzyloxy)-3-(S)-phenyl-4-(2-pro- penyl)-6-(R)-methyl moφholine The title compounds were prepared in a manner similar to Example 23, Step A. Cyclization of 300 mg (0.43 mmol) N-(2-(R)- hydroxypropyl)-N-(prop-2-enyl)-(S)-phenylglycinal, 3,5-bis(trifluoro- methyl)benzyl acetal (from Example 23) was effected using 246 mg (1.29 mmol) of p-toluenesulfonic acid monohydrate and 5 mL of toluene. Flash chromatography on 8 g of silica gel using 20:1 v/v hexanes/ether as the eluant afforded 149 mg (75%) of the products as inseparable diastereomers. Mass Spectrum (FAB): m/Z 460 (M+H, 65%). Step B: 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6- (R)-methyl moφholine and 2-(S)-(3,5-Bis(trifluoro- methyl)benzyloxy)-3-(S)-phenyl-6-(R)-methyl moφholine A solution of 150 mg (0.33 mmol) of 2-(R)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-4-(2-propenyl)-6-(R)- methyl moφholine and 2-(S)-(3,5-bis-(trifluoromethyl)-benzyloxy)-3- (S)-phenyl-4-(2-propenyl)-6-(R)-methyl moφholine (from Example 25, Step A) and 318 mg (0.32 mmol) of tris(triphenyl-phosphine)-rhodium chloride in 20 mL of 4:1 v/v acetonitrile/water was heated at reflux for 1 h. Flash chromatography on 5 g of silica gel using 9:1 v/v hexanes/ether as the eluant afforded 35 mg of the products as a mixture and 26 mg of 2-(R)-(3,5-bis-(trifluoromethyl)benzyloxy)-3-(S)-phenyl- 6-(R)-methyl moφholine (Rf = 0.22 with 3:2 v/v hexanes/ether as the eluant). Chromatography of the mixture on 5 g of silica gel using 20: 1 v/v afforded 14 mg of 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)- phenyl-6-(R)-methyl moφholine (Rf = 0.14 with 3:2 v/v hexanes/ether as the eluant) and 17 mg of 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)- 3-(S)-phenyl-6-(R)-methyl moφholine (41 % total yield). For the (2R.3S.6R) product: Mass Spectrum (FAB): m/Z 420 (M+H, 90%) lH NMR (CDC13, 400 Mhz. ppm) 1.30 (d, 3 H, J = 6.4), 1.74 (br s, 1 H), 2.73 and 2.98 (dAB q, 2 H, J AB = 11.6, J 2.73 = 10.0, J 2.98 = 2.4), 3.65 (d, 1 H, J = 7.2), 3.89 - 3.94 (m, 1 H), 4.45 (d, 1 H, J = 7.2), 4.53 and 4.90 (AB q, 2 H, J = 13.2), 7.28 - 7.38 (m, 3 H), 7.41 - 7.43 (m, 2 H), 7.45 (s, 2 H), 7.70 (s, 1 H). For the (2S.3S.6R) product: Mass Spectrum (FAB): m/Z 420 (M+H, 90%) lH NMR (CDC13, 400 Mhz. ppm) 1.20 (d, 3 H, J = 6.4), 2.04 (br s, 1 H), 2.84 and 3.15 (dAB q, 2 H, J AB = 12.8, J 2.84 = 10.8, J 3.15 = 2.8), 4.08 (d, IH, J = 2.8), 4.08 - 4.15 (m, 1 H), 4.53 and 4.80 (AB q, 2 H, J = 13.2), 4.79 (d, 1 H, J = 2.8), 7.28 - 7.38 (m, 5 H), 7.43 (s, 2 H), 7.70 (s, 1 H). EXAMPLE 26 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(S)-methyl moφholine and 2-(R)-(3,5-Bis-(trifluoromethyl)be:nzyloxy)-3-(R)- phenyl-6-(S)-methyl moφholine Substitution of 250 mg of N-(2-(S)- hydroxy-propyl)-N-(2- propeny l)-(S)-phenylglycinal, 3 ,5-bis-(trifluoromethvl)benzyl acetal (from Example 22) for N-(2-(R)-hydroxypropyl)-N-(2-propenyl)-(R)- phenyl-glycinal, 3,5-bis(trifluoromethyl)benzyl acetal in an experiment similar to the preceding example afforded 42 mg of 2-(S)-(3,5-bis- (trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(S)-methyl moφholine and 17 mg of 2-(S)-(3,5-bis(trifluoro- methyl)benzyloxy)-3-(R)-phenyl-6- (S)-methyl moφholine. EXAMPLE 27 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-methyl moφholine, 2-(S)-(3,5-Bis-(tri-fluoromethyl)benzyloxy)-3-(S)-phenyl- 5-(R)-methyl moφholine, 2-(R or S)-(3,5-Bis(trifluoromethyl)- benzyloxy)-3-(R)-phenyl-5-(R)-methylmoφholine, and 2-(S or R)-(3,5- Bis(trifluoromethyl) benzyloxy)-3-(R)-phenyl-5-(R)-methylmoφholine Execution of the sequence described in Example 19 substituting (R)-2-amino-l-propanol for (R)-l-amino-2-propanol provided a mixture of 55 mg of high Rf material and 56 mg of low Rf material. The high Rf material was processed according to Example 23, Step A above to provide 10 mg of high Rf material (2-(R)-(3,5- Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-methyl moφholine and 7 mg of low Rf material (2-(S)-(3,5-Bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-5-(R)-methyl moφholine. The low Rf material (after being combined with an additional 30 mg of material) was processed according to Example 23, Step A to provide 24 mg of high Rf material (2-(R or S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3- (R)-phenyl-5-(R)-methyl-moφholine and 18 mg of low Rf material (2- (S or R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(R)- methy lmoφholine . 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-methyl morpholine Mass Spectrum (FAB): m/Z 420 (M+H, 100%), 227 (50%), 192 (75%), 176 (65%). NMR (CDC13, 400 MHz, ppm): δ 0.98 (d, 3H, J= 6.3 Hz), 3.16-3.20 (m, IH), 3.43-3.47 (m, IH), 3.79 (d, IH, J= 7.5 Hz), 3.91 (dd, IH, J= 3.2 &11.5 Hz), 4.51 (d, 2H, J= 13.4 Hz), 4.85 (d, IH, J= 13.2 Hz), 7.29- 7.45 (m, 7H), 7.67 (s, IH). 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-methyl morpholine Mass Spectrum (FAB): m/Z 420 (M+H, 48%), 227 (35%), 192 (39%), 176 (100%). NMR (CDCI3, 400 MHz, ppm): δ 1.10 (d, 3H, J= 6.4 Hz), 3.23-3.26 (m, IH), 3.56-3.61 (m, 2H), 4.17 (d, IH, J= 2.3 Hz), 4.51 (d, IH, J= 13.7 Hz), 4.71 (d, IH, J= 2.4 Hz), 4.78 (d, IH, J= 13.5 Hz), 7.28-7.39 (m, 7H), 7.68 (s, IH). 2-(R or S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(R)- methyl moφholine Mass Spectrum (FAB): m/Z 281 (35%), 221 (55%), 207 (45%), 192 (40%), 147 (100%). NMR (CDCI3, 400 MHz, ppm): δ 1.13 (d, 3H, J= 6.6 Hz), 3.10-3.14 (m, IH), 3.66 (dd, IH, J= 6.6 & 11.4 Hz), 3.76 (dd, IH, J= 3.5 & 11.2 Hz), 4.04 (d, IH, J= 4.0 Hz), 4.61 (d, IH, J= 13.2 Hz), 4.74 (d, IH, J= 3.9 Hz), 4.89 (d, IH, 13.2 Hz), 7.26-7.35 (m, 3H), 7.47-7.49 (m, 2H), 7.64 (s, IH), 7.74 (s, IH). 2-(R or S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(R)- methyl moφholine NMR (CDC13, 400 MHz, ppm): δ 1.36 (d, 3H, J= 6.7 Hz), 3.27-3.31 (m, IH), 3.39 (dd, IH, J= 2.2 & 11.3 Hz), 4.16 (dd, IH, J= 3.2 & 11.0 Hz), 4.37 (d, IH, J= 2.3 Hz), 4.53 (d, IH, J= 13.5 Hz), 4.75 (d, IH, J= 2.5 Hz), 4.81 (d, IH, 13.6 Hz), 7.26-7.35 (m, 3H), 7.26-7.43 (m, 7H), 7.68 (s, IH). EXAMPLE 28 2-(R or S)-(3,5-Bis(trifluoromethyl)-benzyloxy)-3-(S)-phenyl-5-(S)- methylmoφholine, 2-(S or R)-(3,5-(-Bis-(trifluoromethyl)benzyloxy)- 3-(S)-phenyl-5-(S)-methyl-moφholine, and 2-(R)-(3,5-Bis(trifluoro- methyl)benzyl-oxy)-3-(R)-phenyl-5-(S)-methylmoφholine Execution of the sequence described in Example 19 substituting (S)-2-amino-l-propanol for (R)-l-amino-2-propanol provided a mixture of 78 mg of high Rf material and 70 mg of low Rf material. The high Rf material was processed according to Example 23, Step A above to provide less than 1 mg of high Rf material (2-(R)-(3,5- Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(S)-methylmoφholine) and 9 mg of low Rf material (2-(S)-(3,5-Bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-5-(S)-methyl moφholine. The low Rf material was processed according to Example 23, Step A to provide 20 mg of high Rf material (2-(R or S)-(3,5-Bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-5-(S)-methylmoφholine and 14 mg of low Rf material (2-(S or R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl- 5-(S)-methylmoφholine. 2-(R or S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(S)- methyl moφholine Mass Spectrum (FAB): m/Z 420 (M+H, 60%), 227 (68%), 192 (56%), 176 (100%). NMR (CDCI3, 400 MHz, ppm): δ 1.12 (d, 3H, J= 6.6 Hz), 3.09-3.14 (m, IH), 3.65 (dd, IH, J= 6.6 & 11.0 Hz), 3.75 (dd, IH, J= 3.6 & 11.1 Hz), 4.04 (d, IH, J= 3.9 Hz), 4.61 (d, IH, J= 13.2 Hz), 4.73 (d, IH, J= 3.9 Hz), 4.89 (d, IH, 13.2 Hz), 7.28-7.35 (m, 3H), 7.47 (d, 2H, 7.0 Hz), 7.64 (s, IH), 7.74 (s, IH). 2-(S or R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(S)- methyl moφholine Mass Spectrum (FAB): m/Z 420 (M+H, 50%), 227 (45%), 192 (40%), 176 (100%). NMR (CDC13, 400 MHz, ppm): δ 1.36 (d, 3H, J= 6.9 Hz), 3.27-3.29 (m, IH), 3.39 (dd, IH, J= 2.2 & 11.1 Hz), 4.15 (dd, IH, J= 3.3 & 11.1 Hz), 4.37 (d, IH, J= 2.5 Hz), 4.52 (d, IH, J= 13.3 Hz), 4.75 (d, IH, J= 2.4 Hz), 4.81 (d, IH, 13.5 Hz), 7.28-7.43 (m, 7H), 7.68 (s, IH). 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)-methyl morpholine NMR (CDCI3, 400 MHz, ppm): δ 1.10 (d, 3H, J= 6.4 Hz), 3.22-3.25 (m, IH), 3.55-3.60 (m, 2H), 4.17 (d, IH, J= 2.3 Hz), 4.51 (d, IH, J= 13.5 Hz), 4.71 (d, IH, J= 2.4 Hz), 4.77 (d, IH, J= 13.6 Hz), 7.28-7.38 (m, 7H), 7.67 (s, IH). EXAMPLE 29 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)- phenylmoφholine, 2-(S)-(3,5-Bis(tri-fluoromethyl)benzyloxy)-3-(S)- phenyl-5-(R)-phenyl-moφholine, and 2-(R or S)-(3,5-Bis(trifluoro- methyl)-benzyloxy)-3-(R)-phenyl-5-(R)-phenylmoφholine Execution of the sequence described in Example 19 substituting (R)-2-amino-2-phenylethanol for (R)-l-amino-2-propanol provided a mixture of 62 mg of high Rf material and 52 mg of low Rf material. The high Rf material was processed according to Example 23, Step A above to provide 16 mg of high Rf material (2-(R)-(3,5- Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-phenylmoφholine and 4 mg of low Rf material (2-(S)-(3,5-Bis(trifluoromethyl)benzyl- oxy)-3-(S)-phenyl-5-(R)-phenylmoφholine . The low Rf material was processed according to Example 23, Step A to provide 4 mg of product (2-(R or S)-(3,5-Bis(trifluoromethyl)benzyl-oxy)-3-(R)-phenyl-5-(R)- phenylmoφholine. 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-phenyl- morpholine NMR (CDCI3, 400 MHz, ppm): δ 3.62 (t, IH, J= 10.7 & 21.5 Hz), 3.93 (d, IH, J= 7.4 Hz), 3.99 (dd, IH, J= 3.1 & 11.2 Hz), 4.18 (dd, IH, J= 3.0 & 10.2 Hz), 4.46 (d, IH, J= 7.4 Hz), 4.53 (d, IH, J= 13.5 Hz), 4.89 (d, IH, J= 13.3 Hz), 7.28-7.55 (m, 12H), 7.69 (s, IH). 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-phenyl- morpholine NMR (CDCI3, 400 MHz, ppm): δ 3.67 (dd, IH, J= 3.5 & 11.0 Hz), 3.89 (d, IH, J= 10.8 & 21.6 Hz), 4.25 (dd, IH, J= 3.3 & 11.0 Hz), 4.34 (d, IH, J= 2.2 Hz), 4.52 (d, IH, J= 13.8 Hz), 4.78-4.87 (m, 2H), 7.28- 7.51 (m, 12H), 7.69 (s, IH). 2-(R or S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(R)- phenylmoφholine NMR (CDCI3, 400 MHz, ppm): δ 4.10-4.25 (m, 2H), 4.30-4.38 (m, IH), 4.48-4.54 (m, IH), 4.59-4.66 (m, IH), 4.86-5.00 (m, 2H), 7.25- 7.74 (m, 13H). EXAMPLE 30 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)- phenylmoφholine, 2-(R)-(3,5-Bis(tri-fluoromethyl)benzyloxy)-3-(R)- phenyl-5-(S)-phenyl-moφholine, 2-(R or S)-(3,5-Bis-(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-5-(S)-phenyl-moφholine, and 2-(R or S)-(3,5- Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(S)-phenylmoφholine Execution of the sequence described in Example 19 substituting (S)-2-amino-2-phenylethanol for (R)-l-amino-2-propanol provided a mixture of 75 mg of high Rf material and 64 mg of low Rf material. The high Rf material was processed according to Example 23, Step A above to provide 23 mg of high Rf material (2-(S)-(3,5- Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)-phenylmoφholine [L-740, 930]) and 7 mg of low Rf material (2-(R)-(3,5-Bis(trifluoro- methyl)benzyloxy)-3-(R)-phenyl-5-(S)-phenylmoφholine.The low Rf material was processed according to Example 23, Step A to provide 26 mg of higher Rf material (2-(R or S)-(3,5-Bis(trifluoromethyl)benzyl- oxy)-3-(S)-phenyl-5-(S)-phenylmoφholine and 6 mg of lower Rf material (2-(R or S)-(3,5-Bis(trifluoro-methyl)benzyloxy)-3-(S)- phenyl-5-(S)-phenylmoφholine. 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)-phenyl- morpholine NMR (CDC13, 400 MHz, ppm): δ 3.60-3.74 (m, IH), 3.94 (d, IH, J= 7.6 Hz), 4.00 (dd, IH, J= 3.2 & 11.3 Hz), 4.18-4.21 (m, IH), 4.50-4.55 (m, 2H,), 4.89 (m, IH), 7.26-7.55 (m, 12H), 7.69 (s, IH). 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)-phenyl- morpholine NMR (CDC13, 400 MHz, ppm): δ 3.68 (dd, IH, J= 3.0 & 11.0 Hz), 3.88-3.94 (m, IH), 4.26-4.30 (m, IH), 4.36 (s, IH), 4.52 (d, IH, J= 13.5 Hz), 4.77-4.86 (m, 2H), 7.27-7.51 (m, 12H), 7.69 (s, IH). 2-(R or S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(S)- phenylmorpholine NMR (CDC13, 400 MHz, ppm): δ 3.93-3.95 (m, IH), 4.06-4.21 (m, 2H), 4.38-4.42 (m, IH), 4.59-4.68 (m, 2H), 4.83-4.94 (m, 2H), 7.25- 7.81 (m, 13H). 2-(R or S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(S)- phenylmoφholine NMR (CDC13, 400 MHz, ppm): δ 3.43-3.59 (m, 2H), 3.82 (d, IH, J= 7.2 Hz), 4.25 (d, IH, J= 12.5 Hz), 4.52-4.63 (m, 3H), 4.80-4.90 (br s, IH), 7.11-7.81 (m, 13H). EX AMPLE 31 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-6-(R)-methyl-3-(S)-phenyl-4- (3-(1.2.4-triazolo)methyl)-moφholine According to the procedure given in Example 17, Step B, 98 mg (0.24 mmole) of 2-(S)-(3,5-bis-(trifluoromethyl)benzyloxy)-3- (S)-phenyl-6-(R)-methyl moφholine (from Example 25 above), 38 mg (0.28 mmole) of N-formyl-2-chloroacetamidrazone (from Example 17, Step A above) and 97 mg (0.7 mmole) of anhydrous potassium carbonate gave, after flash chromatography on 28 g of silica eluting with 1 L of 100:4:0.5 methylene chloride :methanol: ammonia water, a light yellow solid which after recrystallization from hexanes/methylene chloride provided 77 mg (66%) of 2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-6-(R)-methyl-3-(S)-ρhenyl-4-(3-(l,2,4-triazolo)methyl)- moφholine as a white powder. NMR (CDC13, 400 MHz, ppm): δ 1.17 (d, J= 6.3, 3H), 2.29 (t, J= 11.1 , IH), 2.92 (d, J= 11.1, IH), 3.42 (d, J= 15.3, IH), 3.58 (s, IH), 3.88 (d, J= 15.4, IH), 4.20-4.33 (m, IH), 4.43 (d, 13.5, IH), 4.71 (d, J= 2.4, IH), 4.74 (d, J= 13.3, IH), 7.30-7.55 (m, 7H), 7.69 (s, IH), 7.95 (s, IH). EXAMPLE 32 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-6-(R)-methyl-4-(3-(5-oxo- lH.4H-1.2.4-triazolo)methyl)-3-(S)-phenylmoφholine A mixture of 96 mg (0.23 mmole) of 2-(S)-(3,5-bis- (trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(R)-methyl moφholine (from Example 25 above), 46 mg (0.28 mmole) of N-methylcarboxy-2- chloroacetamidrazone and 95 mg (0.69 mmole) of anhydrous potassium carbonate in 3 mL of dry DMF was stirred at room temperature for 20 min, at 60°C for 90 min and then at 120°C for 2 hr. The mixture was cooled to room temperature, taken up in 15 mL of ethyl acetate and was washed with 3x10 mL of water. The combined aqueous layers were back-extracted with 10 mL of ethyl acetate, the combined organic layers were washed with 10 mL of brine, dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by flash chromatography on 28 g of silica eluting with 1L of 100:4 methylene chloride: methanol to give 65 mg (55%) of 2-(S)-(3,5-bis(trifluoro- methyl)benzyl-oxy)-6-(R)-methyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)- methyl)-3-(S)-phenylmoφholine as a light yellow powder. NMR (CDC13, 400 MHz, ppm): δ 1.18 (d, J= 6.2, 3H), 2.15 (t, J= 11.1 , IH), 2.89 (d, J= 14, 2H), 3.49 (d, J= 2.2, IH), 3.61 (d, J= 14.4, IH), 4.20-4.30 (m, IH), 4.45 (d, J= 13.6, IH), 4.67 (d, J= 2.5, IH), 4.79 (d, J= 13.5, IH), 7.25-7.50 (m, 7H), 7.62 (s, IH), 10.07 (s, IH), 10.35 (s, IH). EXAMPLE 33 2-(S)-(3.5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenylmoφholine Step A: 4-Benzyl-2-(S)-hydroxy-3-(R)-phenylmoφholine A solution of 3.72 g (13.9 mmol) of 4-benzyl-3-(R)- phenyl-2-moφholinone, prepared from (R)-phenyl-glycine as described in Example 14, in 28 mL of CH2CI2 was cooled in a -78°C bath under a N2 atmosphere and 14 mL of a 1.5 M solution of DIBAL-H (21 mmol) in toluene were added. After stirring the resulting solution for 0.5 h, it was allowed to warm to -50°C and mantained at this temperature for 0.5 h. The reaction mixture was quenched by adding 10 mL of aqueous potassium sodium tartarate. The mixture was diluted with CH2CI2 and the layers were separated. The aqueous layer was extracted 3 times with CH2CI2. The CH2CI2 layers were washed with brine, dried over Na2S04 and filtered. Concentration of the filtrate furnished 3.32 g (88%) of 4-benzyl-2-(S)-hydroxy-3-(R)-phenylmoφholine suitable for use in the next step. NMR (CDC13) 2.28 (m, IH), 2.71 (m, IH), 2.91 (d, J = 13 Hz, IH), 3.09 (d, J = 6 Hz, IH), 3.69 (d, J = 13 Hz, IH), 3.82 (td, J = 10 Hz and 2 Hz, IH), 3.91 (d, J = 10 Hz, IH), 4.73 (t, J = 6 Hz, IH), 7.2-7.52 (m, 10H). Step B: 4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)-benzyloxy)-3-(R)- phenylmorpholine To a suspension of 0.592 g (14.8 mmol) of NaH in 30 mL of dry THF at 0°C was added 3.32 g (12.3 mmol) of 4-benzyl-2-(S)- hydroxy-3-(R)-phenyl-moφholine prepared in step A. After 15 min 0.915 g of tetrabutylammonium iodide (2.47 mmol) and 2.4 mL (13 mmol) of 3,5-bis(trifluoromethyl)benzyl bromide were added. The resulting mixture was stirred at ice-bath temperature for 1 h, then poured into saturated NaHCθ3 solution and extracted with ethyl acetate (EtOAc). The organic layers were combined, washed with brine, dried over Na2Sθ4 and filtered. The filtrate was concentrated in vacuo and the resiue was chromatographed on a Waters Prep500 HPLC system using 50% EtOAc/Hexane to isolate 3.6 g (59%) of 4-Benzyl-2-(S)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(R)-phenylmoφholine. lH NMR (CDC13) 2.3 (td, J = 11 Hz and 3 Hz, IH), 2.71 (d, J = 11 Hz, IH), 2.90 (d, J = 13 Hz, IH), 3.22 (d, J = 7.3 Hz, IH), 3.75 (m, 2H), 3.93 (m, IH), 4.43 (d, J = 13 Hz, IH), 4.45 (d, J = 7.3 Hz, IH), 4.82 (d, J = 13 Hz, 1 H), 7.19-7.5 (m, 12H), 7.67 (s, IH). Step C: 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl- morpholine A solution of 3.6 g (7.27 mmol) of 4-benzyl-2-(S)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(R)-phenylmoφholine in 100 mL of ethanol and 5 mL of water, containing 0.72 g of 10% Pd/C was hydrogenated on a Parr apparatus for 36 h. The catalyst was filtered and thoroughly washed with EtOAc. The filtrate was concentrated and the residue was partitioned between water and EtOAc. The EtOAc layer was washed with brine, dried over Na2S04, filtered and concentrated. The residue was purified by flash chromatography using a gradient of 10-60 % EtOAc/hexane to isolate 2.05 g (70%) of 2-(S)- (3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenylmoφholine. lH NMR (CDC13) 1.92 (br s, IH), 2.91 (m, IH), 3.05 (td, J =HHz and 3 Hz, IH), 3.68 (d, J = 7 Hz, IH), 3.81 (td, J = 11 Hz and 3 Hz, IH), 4.01 (m, IH), 4.44 (d, J = 7 Hz), 4.5 (d, J = 13 Hz, IH), 4.85 (d, J = 13 Hz, 1 H), 7.28-7.42 (m, 7H), 7.67 (s, IH). EXAMPLE 34 4-(3-(l,2,4-Triazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(R)-phenylmoφholine The title compound was prepared by the procedure of Example 17, step B employing the product of Example 33, step C as a starting material. lH NMR (CDC13) 1.75 (br s, 1 H), 2.61 (td, J =12 Hz and 2 Hz, IH), 2.83 (d, J = 12 Hz, IH), 3.33 (d, J = 7 Hz, IH), 3.48 (d, J = 15 Hz, IH), 3.78 (d, J = 15 Hz, IH), 3.85 (m, IH), 3.99 (m, IH), 4.44 (d, J = 13 Hz, 1 H), 4.49 (d, J = 7Hz, IH), 4.81 (d, J = 13 Hz, IH), 7.23-7.45 (m, 7H), 7.67 (s, IH), 7.96 (s,lH). EXAMPLE 35 4-(3-(5-Oxo-lH,4H-l,2,4-triazolo)methyl)-2-(S)-(3,5-bis-(trifluoro- methyl)benzyloxy)-3-(R)-phenyl-moφholine The title compound was prepared by the procedure of Example 18, steps B & C employing the product of Example 33, step C as a starting material. EXAMPLE 36 4-(2-(Imidazolo)methyl)-2-(S)-(3,5-bis(trifluoro-methyl)benzyloxy)-3- (S)-phenylmoφholine ' A solution of 101 mg (0.25 mmol) of 2-(S)-(3,5-bis(tri- fluoromethyl)benzyloxy)-3-(S)-phenylmoφholine (Example 15), 98 mg (1.0 mmol) of imidazole-2-carboxaldehyde, and 5 drops of glacial acetic acid in 3 ml of methanol was treated with 1.5 ml of 1M sodium cyanoborohydride solution in THF. After 16 hr, the reaction was quenched with 5 ml of saturated aqueous sodium bicarbonate solution and partitioned between 40 ml of ethyl acetate and 20 ml of water. The organic layer was separated, dried over magnesium sulfate, and concentrated in vacuo. Flash chromatography on 8 g of silica gel using 50:1:0.1 methylene chloride/methanol/amonium hydroxide as the eluent afforded 54 mg (44% yield) of the title compound as a white solid. lH NMR (CDC13) 2.60 (dt, J = 3.2 Hz and 12.4 Hz, IH), 2.85 (d, J =12.4 Hz, IH), 3.28 (d, J = 14.4 Hz, IH), 3.59 (d, J =2.8 Hz, IH), 3.66 (dd, J =2.0, 11.6 Hz, IH), 3.84 (d, J =14.4 Hz, IH), 3.94 (app s, 2H), 4.14 (dt, J = 2.0, 12.0 Hz, IH), 4.43 (d, J = 13.6 Hz, IH), 4.71 (d, J = 2.8 Hz, IH), 4.78 (d, J = 13.6 Hz, IH), 6.99 (app s, 2H), 7.25-7.48 (m, 6H), 7.72 (s, IH). Mass spectrum (FAB): m/z 486 (100%, M+H) EXAMPLE 37 4-(2-(Imidazolo)methyl)-2-(S)-(3,5-bis(trifluoro-methyl)benzyloxy)-3- (R)-phenylmorpholine The title compound was prepared by the procedure of Example 36 employing appropriate starting materials. lH NMR (CDC13) 2.53 (td, J = 11 Hz and 3 Hz 5 IH), 2.74 (d, J =12 Hz, IH), 3.23 (d, J = 7Hz, IH), 3.32 (d, J =15 Hz, IH), 3.66 (d, J =15 Hz, IH), 3.77 (td, J =11 Hz and 2 Hz, IH), 3.99 (m, IH), 4.44 (m, 2H), 4.8 (d, J = 13 Hz, IH), 6.94 (s, 2H), 7.2-7.45 (m, 7H), 7.67 (s, IH). EXAMPLE 38 4-(5-(Imidazolo)methyl)-2-(S)-(3,5-bis(trifluoro-methyl)benzyloxy)-3- (R)-phenylmoφholine The title compound was prepared by the procedure of Example 36 employing appropriate starting materials. lH NMR (CDC13) 2.47 (td, J = 12 Hz and 3 Hz, IH), 2.83 (d, J = 12 Hz, IH), 3.2 (m, 2H), 3.61 (d, J =14 Hz, IH), 3.79 (td, J =12 Hz and 2 Hz, IH), 3.96 (m, IH), 4.44 (m, 2H), 4.80 (d, J =13 Hz, IH), 6.81 (s, IH), 7.28-7.45 (m, 7H), 7.60 (s, IH), 7.66 (s, IH). EXAMPLE 39 4-(Aminocarbonylmethyl)-2-(S)-(3,5-bis(trifluoro-methyl)benzyloxy)- 3-(R)-phenylmoφholine Ihe title compound was prepared by the procedure of Example 15 employing appropriate starting materials. lH NMR (CDC13) 2.54 (td, J = 11 Hz and 2 Hz, IH), 2.64 (d, J = 17 Hz, IH), 2.93 (d, J 12 Hz, IH), 3.14 (d, J = 17 Hz, IH), 3.27 (d, J =7 Hz, IH), 3.83 (td, J = 11 Hz and 2 Hz, IH), 4.05 (m, IH), 4.46 (m, 2H), 4.81 (d, J =13 Hz, IH), 5.62 (br s, IH), 6.80 (br s, IH), 7.28-7.32 (m, 7H), 7.67 (s, IH). EXAMPLES 40-43 4-(3-(l,2,4-Triazolo)methyl)-2-(3-(tert-butyl)-5-methylbenzyloxy)-3- phenyl-moφholine, 4-(3-(5-Oxo-lH,4H-l ,2,4-triazolo)methyl)-2-(3- (tert-butyl)-5-methylbenzyloxy)-3-phenyl-moφholine, 4-(2- (Imidazolo)methyl)-2-(3-(tert-butyl)-5-methyl-benzyloxy)-3-phenyl- moφholine, 4-(4-(Imidazolo)-methyl)-2-(3-(tert-butyl)-5-methyl- benzyloxy)-3-phenyl-moφholine The title compounds are each prepared by the procedures of Examples 15, 17 & 18 employing appropriately substituted starting materials and reagents. EXAMPLE 44 2-(S)-(3.5-Dichlorobenzyloxy)-3-(S)-phenylmoφholine Step A: 3,5-Dichlorobenzyl alcohol, trifluoromethanesulfonate ester A solution of 6.09 g (34.4 mmole) of 3,5-dichlorobenzyl alcohol and 8.48 g (41.3 mmole) of 2,6-di-t-butyl-4-methylpyridine in 280 mL of dry carbon tetrachloride under a nitrogen atmosphere was treated with 5.95 mL (35.4 mmole) of trifluoromethanesulfonic anhydride at room temperature. A white precipitate formed shortly after the addition of the anhydride. After 90 min, the slurry was filtered under nitrogen with a Schlenk filter, and the filtrate was concentrated in vacuo. The residue, which was a two-phase oil, was dissolved under nitrogen in 60 mL of dry toluene. The resulting solution was used immediately in Step B below. Step B: 4-Benzyl-2-(S)-(3,5-dichlorobenzyloxy)-3-(S)-phenyl- moφholine A solution of 5.11 g (19.1 mmole) of N-benzyl-3-(S)- phenylmoφholin-2-one (from Example 14) in 100 mL of dry THF was cooled to -75°C under nitrogen and was treated dropwise with 20.5 mL (20.5 mmole) of a 1M solution of lithium tri(sec-butyl)borohydride (L- Selectride®) in THF. After stirring the solution at -75°C for 30 min, a solution of 3,5-dichlorobenzyl alcohol, trifluoromethanesulfonate ester in toluene (from Example 44, Step A) was added by cannula so that the internal temperature was maintained below -60°C. The resulting solution was stirred between -38°C and -50°C for 9 hr, and was then treated with 14 mL of aqueous ammonia and stored at -20°C for 12 hours. The solution was then poured into a mixture of 50 mL of ethyl acetate and 100 mL of water, and the layers were separated. The aqueous phase was extracted with 2x100 mL of ethyl acetate, each extract was washed with brine, the combined organic layers were dried over sodium sulfate, the mixture was filtered and the filtrate concentrated in vacuo. The residue was purified by flash chromato¬ graphy on 235 g of silica eluting with 1.5 L of 100:2 hexanes :ethyl acetate, then 1.5 L of 100:3 hexanes:ethyl acetate and then 1.9 L of 100:5 hexanes:ethyl acetate to give 4.4 g (54%) of an oil, which by lH NMR is a 8:1 mixture of cis:trans moφholines. Mass Spectrum (FAB): m/Z 430,428,426 (M+H, -60%), 268 (M- ArCH2, 100%), 252 (M-A1CH2O, 75%), 222(20%), 159 (45%). lH NMR (CDCI3, 400 MHz, ppm): δ major (cis) isomer: 2.32 (td, J= 12, 3.6, IH), 2.84 (app t, J= 13, 2H), 3.52 (d, J= 2.6, IH), 3.55 (dq, J= 11.3, 1.6, IH), 3.91 (d, J= 13.3, IH), 4.12 (td, J= 11.6, 2.4, IH), 4.29 (d, J= 13.6, IH), 4.59 (d, J= 2.9, IH), 4.60 (d, J= 13.6), 6.70 (s, 2H), 7.13 (t, J= 1.9, IH), 7.2-7.6 (m, 8H), 7.53 (br d, 2H). Step C: 2-(S ) -(3.5-Dichlorobenzyloxy ) -3-(S)-phenyl-moφholine A solution of 0.33 g (0.77 mmole) of 4-benzyl-2-(S)-(3,5- dichlorobenzyloxy)-3-(S)-phenylmoφholine (from Example 44, Step B) and 0.22 g (1.54 mmole) of 1-chloroethyl chloroformate in 4.5 mL of 1 ,2-dichloroethane was placed in a pressure vial which was lowered into an oil bath which was heated to 110°C. After stirring for 60 hr the solution was cooled and concentrated in vacuo. The residue was dissolved in 7 mL of methanol and the resulting solution was heated at reflux for 30 min. The mixture was cooled and treated with several drops of concentrated aqueous ammonia and the solution was concentrated. The residue was partly purified by flash chromatography on 67 g of silica eluting with 1.5 L of 100:1 methylene chloride: methanol, and the rich cuts were purified by flash chormatography on 32 g of silica eluting with 50:50 hexanes: ethyl acetate and then 50:50:5 hexanes:ethyl acetate:methanol to give 0.051 g (20%) of an oil, which by lH NMR was pure cis moφholine. Mass Spectrum (FAB): m/Z 468,466,464 (max 8%)), 338,340 (M+H, 25%), 178 (20%), 162 (100%), 132 (20%),. lH NMR (CDC13, 400 MHz, ppm): δ 1.89 (br s, IH), 3.08 (dd, J= 12.5, 2.9, IH), 3.23 (td, J= 12.2, 3.6, IH), 3.59 (dd, J= 11.3, 2.5, IH), 4.03 (td, J= 11.7, 3, IH), 4.09 (d, J= 2.4, IH), 4.37 (d, J= 13.5, IH), 4.62 (d, J= 13.3, IH), 4.67 (d, J= 2.5, IH), 6.72 (d, J= 1.8, 2H), 7.14 (t, J= 1.8, IH), 7.25-7.40 (m, 5H). EXAMPLE 45 2-(S)-(3,5-dichlorobenzyloxy)-4-(3-(5-oxo-l,2,4-triazolo)methyl)-3- (S)-phenylmorpholine Step A: N-Methylcarboxy-2-chloroacetamidrazone A solution of 5.0 g (66.2 mmol) of chloroacetonitrile in 35 mL of dry methanol was cooled to 0°C and was treated with 0.105 g (1.9 mmol) of sodium methoxide. The ice-bath was removed and the mixture was alowed to stir at room temperature for 30 minutes. To the reaction was then added 0.110 mL (1.9 mmol) of acetic acid and then 5.8 g (64.9 mmol) of methyl hydrazinecarboxylate. After stirring 30 minutes at room temperature, the suspension was concentrated jn vacuo. and placed on the high-vac line overnight, to give 10.5 g (98%) of a yellow powder, a portion of which was employed in Step C below. Step B: 4-(2-(N-Methylcarboxy-acetamidrazono)-2-(S)-(3,5- dichlorobenzyloxy)-3-(S)-phenylmoφholine A solution of 0.050 g (0.15 mmol) of 2-(S)- (3,5-dichlorobenzyloxy)-3-(S)-phenylmoφholine (from Example 44, Step C), 0.034 g (0.21 mmol) of N-methyl-carboxy-2-chloro- acteamidrazone (from Step A), and 0.044 mL (0.25 mmol) N,N- diisopropylethylamine in 1 mL of acetonitrile was stirred at room temperature for 3 hours. The mixture was partitioned between 20 mL of methylene chloride and 10 mL of water. The layers were separated, the organic layer was dried over sodium sulfate and was then concentrated in vacuo. The residue was purified by flash chromato¬ graphy on 35 g of silica eluting with 1L of 50:1: methylene chloride/methanol then 500 mL of 25:1:0.05 methylene chloride:methanol:aqueous ammonia to give 70 mg (~100%) of the product as a white solid. Mass Spectrum (FAB): m/Z 469 (M+H, 60%), 467 (M+H, 100%),291 (40%), 160 (20%), 158 (25%). lH NMR (CDC13, 400 MHz, ppm): δ 2.48 (td, J= 3.5, 12.2, IH), 2.53 (d, J= 14.6, IH), 2.90 (d, J= 11.8, IH), 3.37 (d, J= 14.6, IH), 3.52 (d, J= 2.8), IH), 3.62 (dm, J= 11.4, IH), 3.75 (s, 3H), 4.14 (td, J= 2.2, 11.8, IH), 4.28 (d, J= 13.5, IH), 4.58 (d, J= 13.6), 4.60 (d, J= 2.8, IH), 5.45 (br s, 2H), 6.74 (d, J= 1.9, 2H), 7.15 (t, J= 1.9, IH), 7.30-7.46 (m, 6H). Step C: 2-(S)-(3,5-Dichlorobenzyloxy)-4-(3-(5-oxo-l ,2,4-triazolo)- methyl)-3-(S)-phenylmoφholine A solution of 0.069 g (0.15 mmol) of 4-(2-(N-methyl- carboxyacetamidrazono)-2-(S)-(3,5-dichlorobenzyloxy)-3-(S)- phenylmoφholine (from Step B) in 6 mL of xylenes was heated at reflux for 2 hours. The solution was cooled and concentrated in vacuo. The residue was purified by flash chromatography on 35 g of silica gel eluting with 500 mL of 50:1:0.1 methylene chloride/methanol/aqueous ammonia then 500 mL of 20:1:0.1 methylene chloride/methanol/aqueous ammonia to give 56 mg (88%) of the product as a white powder. Mass Spectrum (FAB): m/Z 437 (M+H, 65%), 435 (M+H, 100%), 259 (85%), 161 (55%). lH NMR (CDC13, 400 MHz, ppm): δ 2.53 (t, J= 11.7, 3.6, IH), 2.88 (d,J= 11.6, IH), 2.96 (d, J= 14.3, IH), 3.54 (d, J= 2.6, IH), 3.63 (dd, J= 11.6, 1.9, IH), 3.68 (d, J= 14.6, IH), 4.16 (t, J= 11.7, 2.2, IH), 4.30 (d, J= 13.6), 4.58 (d, J= 2.7, IH), 4.67 (d, J= 13.6, IH), 6.65 (d, J= 1.8, 2H), 7.07 (t, J= 1.9, IH), 7.29-7.44 (m, 5H), 10.25 (br s, IH), 10.75 (br s, IH). EXAMPLE 46 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(methoxy-carbonyl- methyl)-3-(S)-phenylmorpholine A solution of 300 mg (0.74 mmole) of 2-(S)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-moφholine (from Example 15, Step C) and 0.35 mL (2.0 mmole) of DIEA in 5 mL of acetonitrile was treated with 0.19 mL (2.0 mmole) of methyl bromoacetate and the mixture was stirred for 16 hr at room temperature. The solution was then concentrated in vacuo and the residue partitioned between 30 mL of ether and 15 mL of 0.5 N aqueous KHSO4. The layers were separated and the organic phase was washed with 10 mL of brine and dried over magnesium sulfate. Following filtration, the organic phase was concentrated in vacuo and the residue purified by flash chromatography on 20 g of silica eluting with 80:20 hexanes:ether to give 351 mg (99%) of the product. [a]D = +147.3° (c= 1.6, CHC13). Mass Spectrum (FAB): m/Z 478 (M+H, 40%), 477 (65%), 418 (50%), 250 (95%), 234 (90%), 227 (100%). lH NMR (CDCI3, 400 MHz, ppm): δ 3.02 (br d, 2H), 3.13 (d, J= 16.9, IH), 3.36 (d, J= 16.8), 3.62 (s, 3H), 3.69 (dt, J= 1 1.7, 2.2, IH), 4.03 (br s, IH), 4.23-4.32 (m, IH), 4.44 (d, J= 13.3, IH), 4.68, (d, J= 2.6, IH), 4.81 (d, J= 13.5, IH), 7.30-7.38 (m, 3H), 7.4-7.5 (m, 3H), 7.70 (s, IH). Analysis Calcd for C22H21 F6NO4: C, 55.35; H, 4.43; N, 2.93; F, 23.88 Found: C, 55.09; H, 4.43; N, 2.83; F, 24.05 EXAMPLE 47 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(carboxymethyl)-3-(S)- phenylmoφholine A solution of 0.016 g (0.034 mmole) of 2-(S)-(3,5- Bis(trifluoromethyl)benzyloxy)-4-(methoxy-carbonylmethyl)-3-(S)- phenylmoφholine (from Example 46) in 2 mL of THF and 0.5 mL of water was treated with 0.027 mL (0.067 mmole) of 2.5 N aqueous sodium hydroxide and the mixture was stirred at room temperature for 5 hr. The mixture was treated with 2 drops of 2N aqueous HCl and 3 mL of water and the solution was extracted with 15 mL of 1 :1 hexanes :ethyl acetate. The organic phase was dried over magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by flash chormatography on 13 g of silica eluting with 250 mL of 100:3:0.1 methylene chloride :methanol:acetic acid then 100 mL of 50:2:0.1 methylene chloride :methanol: acetic acid to give 0.014 g (90%) of an oil. Mass Spectrum (FAB): m/Z 464 (M+H, 90%), 420 (M-C02, 10%), 227 (ArCH2, 35%), 220 (M-OCH2Ar, 100%), 161 (20%). IH NMR (CDCI3, 400 MHz, ppm): δ 2.9 (app d, 2H), 3.03 (d, IH), 3.33 (d, IH), 3.72 (d, IH), 3.90 (d, IH), 4.25 (t, IH), 4.44 (d, IH), 4.71 ( d, IH), 4.79 (d, IH), 7.3-7.4 (m, 5H), 7.44 (s, 2H), 7.71 , IH). EXAMPLE 48 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-((2-aminoethyl)amino- carbonylmethyl)-3-(S)-phenylmoφholine hydrochloride A solution of 54 mg (0.11 mmole) of 2-(S)-(3,5-bis(tri- fluoromethyl)benzyloxy)-4-(carboxymethyl)-3-(S)-phenylmoφholine (from Example 46) and 0.15 mL of ethylenediamine (2.3 mmole) in 1 mL of methanol was stirred at 55°C for 48 hr. The mixture was concentrated and the residue purified by flash chromatography on 16 g of silica eluting with 500 mL of 50:4:0.1 methylene chloride:methanol: aqueous ammonia to provide 57 mg(100%) of an oil. The oil was dissolved in ether and was treated with ether saturated with gaseous HCl. After concentration in vacuo. 58 mg (95%) of a rigid oil was obtained. Mass Spectrum (FAB; free base): m/Z 506 (M+H, 100%), 418 (15%), 262(35%), 227 (30%), 173 (40%) lH NMR (CDC13, 400 MHz, ppm): δ 2.56 (d, J= 15.5, IH), 2.59 (td, J= 12.0, 3.6, IH), 2.82 (t, J= 6.5, 2H), 2.96 (d, J= 11.8, IH), 3.21 (d, J= 15.8, IH), 3.25-3.40 (m, 2H), 3.65 (d, J= 2.6, IH), 3.67 (app dt, J= 11.4, ~2, IH), 4.18 (td, J= 11.8, 2.6, IH), 4.33 (d, J= 13.5, 1H),4.69 (d, J= 2.7, IH), 4.79 (d, J= 13.5, IH), 7.25-7.40 (m, 5H), 7.46 (s, 2H), 7.59 (br t, IH), 7.71 (s, IH). EXAMPLE 49 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-((3-amino-propyl)amino carbonylmethyl)-3-(S)-phenylmoφholine hydrochloride A solution of 59 mg (0.12 mmole) of 2-(S)-(3,5-bis(tri- fluoromethyl)benzyloxy)-4-(carboxymethyl)-3-(S)-phenylmoφholine (from Example 46) and 0.21 mL of 1,3-propylenediamine (2.5 mmole) in 1 mL of methanol was stirred at 55°C for 72 hr. The mixture was concentrated and the residue purified by flash chromatography on 16 g of silica eluting with 500 mL of 10:1:0.05 methylene chloride:methanol: aqueous ammonia to provide 56 mg (88%) of an oil. The oil was dissolved in methylene chloride and was treated with methylene chloride saturated with gaseous HCl. After concentration in vacuo. a white paste was obtained. Mass Spectrum (FAB; free base): m/Z 520 (M+H, 100%), 418 (10%), 276(30%), 227 (20%), 174 (30%) lH NMR (CDCI3, 400 MHz, ppm): δ 1.64 (pentet, J= 6.6, 2H), 2.53 (d, J= 15.5, IH), 2.58 (td, J= 12.0, 3.6, IH), 2.73 (t, J= 6.5, 2H), 2.92 (d, J= 11.8, IH), 3.19 (d, J= 15.8, IH), 3.25-3.40 (m, 2H), 3.62 (d, J= 2.6, IH), 3.65 (app dt, J= 11.4, ~2, IH), 4.16 (td, J= 11.8, 2.6, IH), 4.41 (d, J= 13.5, 1H),4.68 (d, J= 2.7, IH), 4.79 (d, J= 13.5, IH), 7.25-7.40 (m, 5H), 7.45 (s, 2H), 7.57 (br t, IH), 7.70 (s, IH). EXAMPLE 50 4-benzyl-5-(S),6-(R)-dimethyl-3-(S)-phenylmoφholinone and 4-benzyl- 5-(R).6-(S)-dimethyl-3-(S)-phenylmoφholinone To a suspension of 1.7 g (7.0 mmole) of N-benzyl-(S)- phenylglycine (Example 13) in 15 ml of methylene chloride at 0°C was added 6.9 ml (13.9 mmole) of trimethylaluminum (2.0 M in toluene). After one hour at 0°C, 0.625 ml (7.0 mmole) of (+/-)-trans-2,3-epoxy butane (dissolved in 2.0 ml of methylene chloride) was added dropwise and then allowed to stir at 22°C for 16 hours. The reaction was then transferred to another flask containing 30 ml of 1 : 1 hexane:methylene chloride and 30 ml of 1M potassium sodium tartrate and stirred at 22°C for 2 hours. The layers were separated, and the aqueous layer was extracted with methylene chloride (3 x 100 ml). The combined organic layers were washed with 25 ml of a saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude alcohol was dissolved in 25 ml of toluene, treated with 93 mg (0.49 mmole) of p-toluenesulfonic acid and heated at 50°C for 20 hours. The reaction was then cooled and concentrated in vacuo . The residue was partitioned between 15 ml of diethyl ether and 10 ml of saturated sodium bicarbonate. The layers were separated, and the organic layer was washed with water (3 x 10 ml). The combined organic layers were washed with 25 ml of a saturated sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and concentrated m vacuo. Flash chromatography on 145 g of silica gel using 1 :4 v/v ethyl acetate/ hexane as the eluant afforded 567 mg of the high Rf lactone(Isomer A) and 388 mg of the low Rf lactone(Isomer B). lH-NMR (400 MHz, CDC13) δ Isomer A: 1.04 (d, 3H, J = 8.0 Hz), 1.24 (d, 3H, J = 8.0 Hz), 2.92 (br qd, IH), 3.41 (d, IH, J = 16.0 Hz), 3.62 (d, IH, J = 16.0 Hz), 4.38 (s, IH), 4.96 (br qd, IH), 7.20-7.42 (m, 8H), 7.58-7.64 (m, 2H); Isomer B: 1.04 (d, 3H, J = 10.0 Hz), 1.39 (d, 3H, J = 10.0 Hz), 3.06 (br qd, IH), 3.53 (d, IH, J = 16.0 Hz), 3.81 (d, IH, J = 16.0 Hz), 4.33 (s, IH), 4.67 (br qd, IH), 7.18-7.50 (m, 10H). Mass Spectrum (FAB): m/z Isomer A: 296 (M+H, 100%), 294 (50%); Isomer B: 296 (M+H, 100%), 294 (50%). EXAMPLE 51 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-[5-(S),6-(R) or 5-(R),6-(S)- dimethvn-3-(S)-phenylmoφholinone Step A: 4-Benzyl-2-(R)-(3,5-bis(trifluoromethyl)-benzyloxy)-[5- (S),6-(R) or 5-(R),6-(S)-dimethyl]-3-(S)-phenyl- moφholinone According to the procedure in Example 15, Step B, 251 mg (0.85 mmole) of Isomer A from Example 50 (4-benzyl-[5-(S),6-(R) or 5-(R)-6-(S)-dimethyl]-3-(S)-phenylmoφholinone) provided 238 mg (53%) of the product as an oil. lH-NMR (400 MHz, CDCI3) δ 1.03 (d, 3H, J = 6.7 Hz), 1.13 (d, 3H, J = 6.6 Hz), 2.61 (qd, IH, J = 2.2 & 6.6 Hz), 3.26 (d, IH, J = 13.9 Hz), 3.55 (d, IH, J = 13.9 Hz), 3.63 (d, IH, J = 7.6 Hz), 4.01 (qd, IH, J = 2.3 & 6.6 Hz), 4.44 (d, IH, J = 13.1 Hz), 4.53 (d, IH, J = 7.7 Hz), 4.71 (s, IH), 4.85 (d, IH, J = 13.2 Hz), 7.20-7.35 (m, 9H), 7.46-7.48 (m, 2H), 7.67 (s, IH), 7.81 (s, IH). Mass Spectrum (FAB): m/z 523 (M+H, 100%), 296 (95%), 280 (40%), 227 (50%). Step B: 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-[5-(S),6-(R) or 5-(R).6-(S)-dimethyll-3-(S)-phenylmoφholinone According to the procedure in Example 15, Step C, 260 mg of starting material from Step A [derived from Isomer A in Example 50 (4-Benzyl-2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-[5-(S),6-(R) or 5- (R),6-(S)-dimethyl]-3-(S)-phenylmoφholinone)] provided 122 mg (57%) of the product as an oil. lH-NMR (400 MHz, CDCI3) δ 1.19 (d, 3H, J = 6.5 Hz), 1.27 (d, 3H, J = 6.7 Hz), 2.97 (qd, IH, J = 2.9 & 6.9 Hz), 3.96 (d, IH, J = 7.7 Hz), 4.08- 4.11 (m, 2H), 4.39 (d, IH, J = 7.7 Hz), 4.50 (d, IH, J = 13.3 Hz), 4.88 (d, IH, J = 13.2 Hz), 7.27-7.33 (m, 3H), 7.40-7.42 (m, 4H), 7.67 (s, IH). Mass Spectrum (FAB): m/z 434 (M+H, 45%), 227 (35%), 206 (40%), 190 (100%). EXAMPLE 52 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-[5-(R),6-(S) or 5-(S),6-(R)- dimethyll-3-(S)-phenylmoφholinone Step A: 4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)-benzyloxy)-[5- (R),6-(S) or 5-(S),6-(R)-dimethyl]-3-(S)-phenyl- moφholinone According to the procedure in Example 15, Step B, 449 mg (1.52 mmole) of Isomer B from Example 50 (4-benzyl-[5-(R),6-(S) or 5-(S)-6-(R)-dimethyl]-3-(S)-phenylmoφholinone) provided 400 mg (51 %) of the product as an oil. lH-NMR (400 MHz, CDCI3) δ 0.90 (d, 3H, J = 6.8 Hz), 1.37 (d, 3H, J = 6.6 Hz), 2.86-2.89 (br qd, IH), 3.47 (d, IH, J = 15.0 Hz), 3.82-3.85 (m, 2H), 3.99-4.02 (br qd, IH), 4.45 (d, IH, J = 13.6 Hz), 4.81 (d, IH, J = 2.0 Hz), 4.87 (d, IH, J = 13.5 Hz), 7.17-7.83 (m, 13H). Step B: 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-[5-(S),6-(R) or 5-(R).6-(S)-dimethyll-3-(S)-phenylmoφholinone According to the procedure in Example 15, Step C, 400 mg of starting material from Step A [derived from Isomer B in Example 50 (4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-[5-(R),6-(S) or 5- (S),6-(R)-dimethyl]-3-(S)-phenylmoφholinone)] provided 230 mg (69%) of the product as an oil. lH-NMR (400 MHz, CDCI3) δ 1.08 (d, 3H, J = 6.7 Hz), 1.38 (d, 3H, J = 7.0 Hz), 3.41-3.45 (br qd, IH), 3.85-3.89 (br qd, IH), 4.16 (d, IH, J = 2.9 Hz), 4.49 (d, IH, J = 13.6 Hz), 4.71 (d, IH, J = 2.9 Hz), 4.82 (d, IH, J = 13.6 Hz), 7.25-7.36 (m, 7H), 7.66 (s, IH). Mass Spectrum (FAB): m/z 434 (M+H, 35%), 227 (40%), 206 (40%), 190 (100%). EXAMPLE 53 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(3-(l,2,4-triazolo)- methyl)-[5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3-(S)-phenyl- morpholinone A mixture of 62 mg (0.14 mmole) of 2-(R)-(3,5-Bis(tri- fluoromethyl)benzyloxy)-[5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3-(S)- phenylmoφholinone (from Example 51 , Step B), 62 mg (0.45 mmole) of anhydrous potassium carbonate and 26 mg (0.19 mmole) of N- formyl-2-chloroacetamidrazone (from Example 17, Step A) in 2.0 ml of N,N-dimethylformamide was heated to 60°C for 2 hours and then 118°C for 1.5 hours. The mixture was then allowed to cool to room temperature and then quenched with 5 mis of water and diluted with 15 mis of ethyl acetate. The layers were separated and the organic layer was washed with ethyl acetate (2 x 10 mis). The combined organic layers were washed with 10 mis of brine, dried over anhydrous magnesium sulfate, filtered, and concentrated m vacuo. Flash chromatography on 42 g of silica gel using 95:5 v/v methylene chloride/ methanol as the eluant afforded 42 mg (57%) of a clear oil. 1H-NMR (400 MHz, CDCI3) δ 1.13 (d, 3H, J = 6.5 Hz), 1.19 (d, 3H, J = 6.5 Hz), 2.65 (qd, IH, J = 1.9 & 6.5 Hz), 3.58 (d, IH, J = 15.5 Hz), 3.65 (d, IH, J = 7.7 Hz), 3.75 (d, IH, J = 15.4 Hz), 4.06 (qd, IH, J = 2.2 & 6.6 Hz), 4.45 (d, IH, J = 13.2 Hz), 4.54 (d, IH, J = 7.7 Hz), 4.84 (d, IH, J = 13.2 Hz), 7.28-7.37 (m, 7H), 7.67 (s, IH), 7.89 (s, IH). Mass Spectrum (FAB): m/z 516 (M+H, 52%), 287 (28%), 271 (100%), 227 (40%), 202 (38%). EXAMPLE 54 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(3-(5-oxo-l,2,4-triazolo) methyl)-[5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3-(S)-phenyl- morpholinone A solution of 96 mg (0.22 mmole) of 2-(R)-(3,5- Bis(trifluoromethyl)benzyloxy)-[5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3- (S)-phenylmoφholinone (from Example 51 , Step B), 92 mg (0.66 mmole) of potassium carbonate and 48 mg (0.29 mmole) of N- methylcarboxy-2-chloroacetamidrazone (from Example 18, Step A) in 4 mL of DMF was heated at 60°C for 1.5 hr and at 120°C for 3.5 hr. The mixture was cooled to room temperature and was partitioned between 15 mL of water and 25 mL of ethyl acetate. The aqueous layer was extracted with 3x10 mL of ethyl acetate, the combined organic layers were washed with 10 mL of brine, dried over sodium sulfate, filtered and concentrated in vacuo. The residue was partly purified by flash chromatography on 42 g of silica gel using 2L of 98:2 v/v methylene chloride/ methanol as the eluant and the rich cuts were purified under the same conditions to give 38 mg (33%) of a clear oil. lH-NMR (400 MHz, CDCI3) δ 1.09 (d, 3H, J = 6.5 Hz), 1.20 (d, 3H, J = 6.6 Hz), 2.64 (qd, IH, J = 2.4 & 6.6 Hz), 3.33 (s, IH), 3.56 (d, IH, J = 7.6 Hz), 4.11 (qd, IH, J = 2.4 & 6.6 Hz), 4.41 (d, IH, J = 13.2 Hz), 4.57 (d, IH, J = 7.7 Hz), 4.82 (d, IH, J = 13.2 Hz), 7.25-7.30 (m, 5H), 7.40 (d, 2H, J = 5.7 Hz), 7.65 (s, IH), 9.46 (s, IH), 10.51 (s, IH). Mass Spectrum (FAB): m/z 531 (M+H, 98%), 287 (100%), 227 (80%), 189 (65%). EXAMPLE 55 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(3-(l,2,4-triazolo)methyl)- [5-(R).6-(S) or 5-(S).6-(R)-dimethyll-3-(S)-phenylmoφholinone According to the procedure in Example 53, 75 mg (0.17 mmole) of 2-(S)-(3,5-Bis(trifluoromethyl)-benzyloxy)-[5-(R),6-(S) or 5-(S),6-(R)-dimethyl]-3-(S)-phenylmoφholinone (from Example 52, Step B) provided, after flash chromatography on 73 g of silica gel using 98:2 v/v methylene chloride/ methanol as the eluant , 46 mg (52%) of a yellow oil. lH-NMR (400 MHz, CDCI3) δ 1.04 (d, 3H, J = 6.6 Hz), 1.46 (d, 3H, J = 6.7 Hz), 3.05-3.08 (m, IH), 3.74-3.81 (m, 2H), 3.91-3.95 (m, 2H), 4.41 (d, IH, J = 13.2 Hz), 4.69 (d, IH, J = 3.2 Hz), 4.82 (d, IH, J = 13.5 Hz), 7.31-7.35 (m, 5H), 7.43-7.45 (m, 2H), 7.68 (s, IH), 7.91 (s, IH). Mass Spectrum (El): m/z 432 (36%), 287 (60%), 270 (65%), 227 (30%), 187 (48%), 83 (100%). EXAMPLE 56 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(3-(5-oxo-l ,2,4-triazolo) methyl)-[5-(R),6-(S) or 5-(S),6-(R)-dimethyl]-3-(S)-phenyl- morpholinone According to the procedure in Example 54, 86 mg (0.2 mmole) of 2-(S)-(3,5-Bis(trifluoromethyl)-benzyloxy)-[5-(R),6-(S) or 5-(S),6-(R)-dimethyl]-3-(S)-phenylmoφholinone (from Example 47, Step B) provided, after flash chromatography on 73 g of silica gel using 95:5 v/v methylene chloride/ methanol as the eluant, 32 mg (30%) of a yellow oil. lH-NMR (400 MHz, CDCI3) δ 1.03 (d, 3H, J = 6.7 Hz), 1.40 (d, 3H, J = 6.8 Hz), 3.00 (qd, IH, J = 3.8 & 6.8 Hz), 3.44 (d, IH, J = 16.1 Hz), 3.63 (d, IH, J = 16.0 Hz), 3.82 (d, IH, J = 3.3 Hz), 3.95 (qd, IH, J = 3.7 & 6.7 Hz), 4.43 (d, IH, J = 13.5 Hz), 4.73 (d, IH, J = 3.3 Hz), 4.84 (d, IH, J = 13.6 Hz), 7.28-7.47 (m, 7H), 7.68 (s, IH), 9.52 (d, 2H). Mass Spectrum (FAB): m/z 531 (M+H, 100%), 287 (55%), 227 (25%), 147 (50%). EXAMPLE 57 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(2-(l-(4-benzyl)- piperidino)ethyl)-3-(S)-phenylmoφholine To a solution of 2-(S)-(3,5-bis(trifluoro-methyl)- benzyloxy)-3-(S)-phenylmoφholine (50 mg, 0.12 mmol) and 4-benzyl- 1 - 2-chloroethyl)piperidine hydrochloride (50 mg, 0.18 mmol) in acetonitrile (0.5 mL) was added diisopropylethylamine (O.065 mL, 0.36 mmol) at room temperature. After 60 hours, TLC (5% MeOH/2% Et3N/93% EtOAc) indicated that the reaction was only partially complete. The reaction was diluted with methylene chloride and washed with water, then brine, dried over sodium sulfate and evaporated. Prep TLC (5% MeOH/2% Et3N/93% EtOAc) afforded 36 mg (50%) of the title compound as an oil. lH-NMR (400 MHz, CDC13) δ 1.1-1.4 (m, 2 H), 1.4-1.65 (2 m, 4 H), 1.65-2.05 (m, 3 H), 2.05-2.3 (m, IH), 2.35-2.5 (m and d, J = 7 Hz, 3 H), 2.55 (br t, J = 11 Hz, 1 H), 2.65-2.8 (m, 2 H), 3.09 (d, J = 11 Hz, 1 H), 3.50 (d, J = 2.5 Hz, 1 H), 3.66 (dd, J = 2 and 11 Hz, 1 H), 4.15 (dt, J = 2 and 12 Hz, 1 H), 4.38 and 4.75 (AB q, J = 13 Hz, 2 H), 4.61 (d, J = 2.5 Hz, 1 H), 7.06 (d, J = 7 Hz, 2 H), 7.15 (t, J = 7 Hz, 1 H), 7.2-7.35 (m, 5 H), 7.36 (m, 4 H), 7.75 (s, IH). EXAMPLE 58 (S)-(4-Fluorophenyl)glycine Via Chiral Synthesis: Step A: 3-(4-Fluorophenyl)acetyl-4-(S)-benzyl-2-oxazolidinone An oven-dried, 1 L 3 -necked flask, equipped with a septum, nitrogen inlet, thermometer, and a magnetic stirring bar, was flushed with nitrogen and charged with a solution of 5.09 g (33.0 mmol) of 4-fluorophenylacetic acid in 100 mL of anhydrous ether. The solution was cooled to -10°C and treated with 5.60 mL (40.0 mmol) of triethylamine followed by 4.30 mL (35.0 mmol) of trimethylacetyl chloride. A white precipitate formed immediately. The resulting mixture was stirred at -10°C for 40 minutes, then cooled to -78°C. An oven-dried, 250 mL round bottom flask, equipped with a septum and a magnetic stirring bar, was flushed with nitrogen and charged with a solution of 5.31 g (30.0 mmol) of 4-(S)-benzyl-2- oxazolidinone in 40 mL of dry THF. The solution was stirred in a dry ice/acetone bath for 10 minutes, then 18.8 mL of 1.6 M n-butyllithium solution in hexanes was slowly added. After 10 minutes, the lithiated oxazolidinone solution was added, via cannula, to the mixture in the 3- necked flask. The cooling bath was removed from the resulting mixture and the temperature was allowed to rise to 0°C. The reaction was quenched with 100 mL of saturated aqueous ammonium chloride solution, transferred to a 1 L flask, and the ether and THF were removed in vacuo. The concentrated mixture was partitioned between 300 mL of methylene chloride and 50 mL of water and the layers were separated. The organic layer was washed with 200 mL of 2 N aqueous hydrochloric acid solution, 300 mL of saturated aqueous sodium bicarbonate solution, dried over magnesium sulfate and concentrated in vacuo. Flash chromatography on 400 g of silica gel using 3:2 v/v hexanes/ether as the eluant afforded 8.95 g of an oil that slowly solidified on standing. Recrystallization from 10:1 hexanes/ether afforded 7.89 g (83%) of the title compound as a white solid, mp 64- 66°C. Mass Spectrum (FAB): m/Z 314 (M+H, 100%), 177 (M- A1CH2CO+H, 85%). lH-NMR (400 MHz, CDCI3;: δ 2.76 (dd, 1 H, J = 13.2, 9.2), 3.26 (dd, J = 13.2, 3.2), 4.16-4.34 (m, 4 H), 4.65-4.70 (m, 1 H), 7.02-7.33 (m, 9 H). Analysis: Calcd for Cl 8H16FNO3: C, 69.00; H, 5.15; N, 4.47; F, 6.06 Found: C, 68.86; H, 5.14; N, 4.48; F, 6.08 Step B: 3-((S)-Azido-(4-fluorophenyl))acetyl-4-(S)-benzyl-2- oxazolidinone An oven-dried, 1 L 3-necked flask, equipped with a septum, nitrogen inlet, thermometer, and a magnetic stirring bar, was flushed with nitrogen and charged with a solution of 58.0 mL of 1 M potassium bis(trimethylsilyl)amide solution in toluene and 85 mL of THF and was cooled to -78°C. An oven-dried, 250 mL round-bottomed flask, equipped with a septum and a magnetic stirring bar, was flushed with nitrogen and charged with a solution of 7.20 g (23.0 mmol) of 3- (4-fluorophenyl)acetyl-4-(S)-benzyl-2-oxazolidinone (from Example 58, Step A) in 40 mL of THF. The acyl oxazolidinone solution was stirred in a dry ice/acetone bath for 10 minutes, then transferred, via cannula, to the potassium bis(trimethylsilyl)amide solution at such a rate that the internal temperature of the mixture was maintained below -70°C. The acyl oxazolidinone flask was rinsed with 15 mL of THF and the rinse was added, via cannula, to the reaction mixture and the resulting mixture was stirred at -78°C for 30 minutes. An oven- dried, 250 mL round-bottomed flask, equipped with a septum and a magnetic stirring bar, was flushed with nitrogen and charged with a solution of 10.89 g (35.0 mmol) of 2,4,6-triisopropylphenylsulfonyl azide in 40 mL of THF. The azide solution was stirred in a dry ice/acetone bath for 10 minutes, then transferred, via cannula, to the reaction mixture at such a rate that the internal temperature of the mixture was maintained below -70°C. After 2 minutes, the reaction was quenched with 6.0 mL of glacial acetic acid, the cooling bath was removed and the mixture was stirred at room temperature for 18 hours. The quenched reaction mixture was partitioned between 300 mL of ethyl acetate and 300 mL of 50% saturated aqueous sodium bicarbonate solution. The organic layer was separated, dried over magnesium sulfate, and concentrated in vacuo. Flash chromatography on 500 g of silica gel using 2:1 v/v, then 1:1 v/v hexanes/methylene chloride as the eluant afforded 5.45 g (67%) of the title compound as an oil. IR Spectrum (neat, cm-1): 2104, 1781, 1702. lH-NMR (400 MHz, CDCI3): δ 2.86 (dd, 1 H, J = 13.2, 9.6), 3.40 (dd, 1 H, J = 13.2, 3.2), 4.09-4.19 (m, 2 H), 4.62-4.68 (m, 1 H), 6.14 (s, 1 H), 7.07-7.47 (m, 9 H). Analysis: Calcd for C18H15FN4O3: C, 61.01; H, 4.27; N, 15.81 ; F, 5.36 Found: C, 60.99; H, 4.19; N, 15.80; F, 5.34 Step C: (S)-Azido-(4-fluorophenyl)acetic acid A solution of 5.40 g (15.2 mmol) of 3-((S)-azido-(4- fluorophenyl))acetyl-4-(S)-benzyl-2-oxazolidinone (from Example 58, Step B) in 200 mL of 3:1 v/v THF/water was stirred in an ice bath for 10 minutes. 1.28 g (30.4 mmol) of lithium hydroxide monohydrate was added in one portion and the resulting mixture was stirred cold for 30 minutes. The reaction mixture was partitioned between 100 mL of methylene chloride and 100 mL of 25% saturated aqueous sodium bicarbonate solution and the layers were separated. The aqueous layer was washed with 2 x 100 mL of methylene chloride and acidified to pH 2 with 2 N aqueous hydrochloric acid solution. The resulting mixture was extracted with 2 x 100 mL of ethyl acetate; the extracts were combined, washed with 50 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate, and concentrated in vacuo to afford 2.30 g (77%) of the title compound as an oil that was used in the following step without further purification. IR Spectrum (neat, cm-1): 2111 , 1724. lH-NMR (400 MHz, CDCI3): δ 5.06 (s, 1 H), 7.08-7.45 (m, 4 H), 8.75 (br s, 1 H). Step D: (S)-(4-Fluorophenyl)glycine A mixture of 2.30 g (11.8 mmol) of (S)-azido-(4- fluorophenyl)acetic acid (from Example 58, Step C), 250 mg 10% palladium on carbon catalyst and 160 mL 3:1 v/v water/acetic acid was stirred under an atmosphere of hydrogen for 18 hours. The reaction mixture was filtered through Celite and the flask and filter cake were rinsed well with ~1L of 3:1 v/v water/acetic acid. The filtrate was concentrated in vacuo to about 50 mL of volume. 300 mL of toluene was added and the mixture concentrated to afford a solid. The solid was suspended in 1:1 v/v methanol/ether, filtered and dried to afford 1.99 g (100%) of the title compound. lH-NMR (400 MHz, D2θ + NaOD): δ 3.97 (s, 1 H), 6.77 (app t, 2 H, J = 8.8), 7.01 (app t, 2 H, J = 5.6). Via Resolution: Step A': 4-Fluorophenylacetyl chloride A solution of 150 g (0.974 mol) of 4-fluorophenylacetic acid an 1 mL of N,N-dimethylformamide in 500 mL of toluene at 40 °C was treated with 20 mL of thionyl chloride and heated to 40°C. An additional 61.2 mL of thionyl chloride was added dropwise over 1.5 hours. After the addition, the solution was heated at 50 °C for 1 hour, the solvent was removed in vacuo and the residual oil was distilled at reduced pressure (1.5 mmHg) to afford 150.4 g (89.5%) of the title compound, bp = 68-70 °C. Step B': Methyl 2-bromo-2-(4-fluoro)phenylacetate A mixture of 150.4 g (0.872 mol) of4-fluorophenylacetyl chloride (from Example 58, Step A') and 174.5 g (1.09 mol) of bromine was irradiated at 40-50 °C with a quartz lamp for 5 hours. The reaction mixture was added dropwise to 400 mL of methanol and the solution was stirred for 16 hours. The solvent was removed in vacuo and the residual oil was distilled at reduced pressure (1.5 mmHg) to afford 198.5 g (92%) of the title compound, bp = 106-110 °C. Step C: Methyl (±)-(4-fluorophenyl)glvcine A solution of 24.7 g (0.1 mol) of methyl 2-bromo-2-(4- fluoro) phenylacetate (from Example 58, Step B') and 2.28 g (0.01 mol) of benzyl triethylammonium chloride in 25 mL of methanol was treated with 6.8 g (0.105 mol) of sodium azide and the resulting mixture was stirred 20 hours at room temperature. The reaction mixture was filtered; the filtrate was diluted with 50 mL of methanol and hydrogenated in the presence of 0.5 g of 10% Pd/C at 50psi for 1 hour. The solution was filtered and the solvent removed in vacuo. The residue was partitioned between 10% aqueous sodium carbonate solution and ethyl acetate. The organic phase was washed with water, saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated in vacuo to afford 9.8 g of the title compound as an oil. Step D': Methyl (S)-(4-fluorophenyl)glycinate A solution of 58.4 g of methyl (±)-4-fluorophenylglycinate (from Example 58* Step C) in 110 mL of 7:1 v/v ethanol/water was mixed with a solution of 28.6 g (0.0799 mol) of 0,0'-(+)- dibenzoyltartaric acid ((+)-DBT) (28.6g, 0.0799mol) in 110 mL of 7:1 v/v ethanol: water and the resulting solution was allowed to age at room temperature. Ethyl acetate (220ml) was added after crystallization was complete and the resulting mixture was cooled to -20 °C and filtered to afford 32.4 g of methyl (S)-(4-fluorophenyl) glycinate, (+)-DBT salt (ee = 93.2%). The mother liquors were concentrated in vacuo and the free base was liberated by partitioning between ethyl acetate and aqueous sodium carbonate solution. A solution of free base, so obtained, in 110 mL of 7:1 v/v ethanol/water was mixed with a solution of 28.6 g (0.0799 mol) of 0,0'-(-)-dibenzoyltartaric acid ((-)-DBT) (28.6g, 0.0799mol) in 110 mL of 7:1 v/v ethanol: water and the resulting solution was allowed to age at room temperature. Ethyl acetate (220ml) was added after crystallization was complete and the resulting mixture was cooled to -20 °C and filtered to afford 47.0 g of methyl (R)-(4-fluorophenyl) glycinate, (-)-DBT salt (ee = 75.8%). Recycling of the mother liquors and addition of (+)-DBT gave a second crop of 7.4 g of (S)-(4-fluorophenyl) glycinate, (+)-DBT salt (ee = 96.4%). The two crops of the (S)-amino ester (39.8 g) were combined in 200 mL of 7:1 v/v ethanol/water, heated for 30 minutes and cooled to room temperature. Addition of ethyl acetate, cooling, and filtration afforded 31.7 g of (S)-(4-fluorophenyl) glycinate, (+)-DBT salt (ee>98%). Enatiomeric excesses was determined by chiral HPLC (Crownpak CR(+) 5% MeOH in aqHClθ4 pH2 1.5ml/min 40 C 200nm). A mixture of 17.5 g of (S)-(4-fluorophenyl) glycinate, (+)- DBT salt and 32 mL of 5.5 N HCl (32ml) was heated at reflux for 1.5 hours. The reaction mixture was concentrated in vacuo and the residue was dissolved in 40 mL of water. The aqueous solution was washed 3 x 30 mL of ethyl acetate and the layers were separated. The pH of the aqueous layer was adjusted to 7 using ammonium hydroxide and the precipitated solid was filtered to afford 7.4 g of the title compound (ee = 98.8%). EXAMPLE 59 3-(S)-(4-Fluorophenyl)-4-benzyl-2-moφholinone Step A: N-Benzyl (S)-(4-fluorophenyl)glvcine A solution of 1.87 g (11.05 mmol) of (S)-(4-fluorophenyl)- glycine (from Example 58) and 1.12 mL (11.1 mmol) of benzaldehyde in 11.1 mL of 1 N aqueous sodium hydroxide solution and 11 mL of methanol at 0°C was treated with 165 mg (4.4 mmol) of sodium borohydride. The cooling bath was removed and the resulting mixture was stirred at room temperature for 30 minutes. Second portions of benzaldehyde (1.12 mL (11.1 mmol)) and sodium borohydride 165 mg (4.4 mmol) were added to the reaction mixture and stirring was continued for 1.5 hours. The reaction mixture was partitioned between 100 mL of ether and 50 mL of water and the layers were separated. The aqueous layer was separated and filtered to remove a small amount of insoluble material. The filtrate was acidified to pH 5 with 2 N aqueous hydrochloric acid solution and the solid that had precipitated was filtered, rinsed well with water, then ether, and dried to afford 1.95 g of the title compound. lH-NMR (400 MHz, D2θ + NaOD): δ 3.33 (AB q, 2 H, J = 8.4), 3.85 (s, 1 H), 6.79-7.16 (m, 4 H). Step B: 3-(S)-(4-Fluorophenyl)-4-benzyl-2-moφholinone A mixture of 1.95 g (7.5 mmol) of N-benzyl (S)-(4- fluorophenyl)glycine, 3.90 mL (22.5 mmol) of N,N-diisopropyl- ethylamine, 6.50 mL (75.0 mmol) of 1 ,2-dibromoethane and 40 mL of N,N-dimethylformamide was stirred at 100°C for 20 hours (dissolution of all solids occurred on warming). The reaction mixture was cooled and concentrated in vacuo. The residue was partitioned between 250 mL of ether and 100 mL of 0.5 N potassium hydrogen sulfate solution and the layers we r e separated. The organic layer was washed with 100 mL of saturated aqueous sodium bicarbonate solution, 3 x 150 mL of water, dried over magnesium sulfate, and concentrated in vacuo. Flash chromatography on 125 g of silica gel using 3:1 v/v hexanes/ether as the eluant afforded 1.58 g (74%) of the title compound as an oil. lH-NMR (400 MHz, CDCI3): δ 2.65 (dt, 1 H, J = 3.2, 12.8), 3.00 (dt, 1 H, J = 12.8, 2.8), 3.16 (d, 1 H, J = 13.6), 3.76 (d, 1 H, J = 13.6), 4.24 (s, 1 H), 4.37 (dt, 1 H, J = 13.2, 3.2), 4.54 (dt, 1 H, J = 2.8, 13.2), 7.07- 7.56 (m, 9 H). EXAMPLE 60 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluorophenyl)-4- benzylmorpholine The title compound was prepared in 72% yield from 3-(S)- (4-fluorophenyl)-4-benzyl-2-moφholinone (from Example 59) using procedures analogous to those in Example 15, Steps A and B. lH-NMR (200 MHz, CDCI3): δ 2.37 (dt, 1 H, J = 3.6, 11.8), 2.83-2.90 (m, 2 H), 3.55-3.63 (m, 2 H), 3.85 (d, 1 H, J = 13.4), 4.14 (dt, 1 H, J = 2.0, 11.8), 4.44 (d, 1 H, J = 13.6), 4.66 (d, 1 H, J = 2.8), 4.79 (d, 1 H, J = 13.4), 7.00-7.70 (12 H). EXAMPLE 61 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluorophenyl) morpholine The title compound was prepared in 70% yield from 2-(S)- (3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluorophenyl)-4- benzylmoφholine (from Example 60) using a procedure analogous to that in Example 15, Step C. Mass Spectrum (FAB): m/Z 424 (M+H, 40%). lH-NMR (400 MHz, CDCI3): δ 1.80 (br s, 1 H), 3.11 (app dd, 1 H, J = 2.2, 12.4), 3.25 (dt, 1 H, J = 3.6, 12.4), 3.65 (app dd, 1 H, J = 3.6, 11.4), 4.05 (dt, 1 H, J = 2.2, 11.8), 4.11 (d, 1 H, J = 2.2), 4.53 (d, 1 H, J = 13.6), 4.71 (d, 1 H, J = 2.2), 4.83 (d, 1 H, J = 13.6), 7.04 (t, 2 H, J = 7.2), 7.33-7.37 (m, 2 H), 7.42 (s, 2 H), 7.72 (s, 1 H). EXAMPLE 62 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluorophe (5-oxo- lH.4H-1.2.4-triazolo)methylmoφholine The title compound was prepared in 69% yield from 2-(S)- (3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluorophenyl)moφholine (from Example 61) using a procedure analogous to that in Example 18. Mass Spectrum (FAB): m/Z 521 (M+H, 100%). lH-NMR (400 MHz, CDCI3): δ 2.55 (dt, 1 H, J = 3.6, 12.0), 2.91 (d, 1 H, J = 11.6), 2.93 (d, 1 H, J = 14.4), 3.57 (d, 1 H, J = 2.8), 3.59 (d, 1 H, J = 14.4), 3.67-3.70 (m, 1 H), 4.18 (dt, 1 H, J = 2.4, 11.6), 4.48 (d, 1 H, J = 13.6), 4.65 (d, 1 H, J = 2.8), 4.84 ( d, 1 H, J = 13.6), 7.07 (t, 2 H, J = 8.4), 7.40 (s, 2 H), 7.45-7.48 (m, 2 H), 7.68 (s, 1 H), 10.04 (br s, 1 H), 10.69 (br s, 1 H). Analysis: Calcd for C22H 19F7N4O3 : C, 50.78; H, 3.68; N, 10.77; F, 25.55 Found: C, 50.89; H, 3.76; N, 10.62; F, 25.56 EXAMPLE 63 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-((3-pyridyl)methyl carbonyl)-3-(R)-phenylmorpholine A solution of 55 mg (0.315 mmol) of 4-pyridylacetic acid in 1 mL of CH2CI2, containing 0.079 mL (0.715 mmol) of N- methylmoφholine, 53 mg (0.37 mmol) of HOBt and 73 mg (0.37 mmol) of EDC was stirred for 10 min. A solution of 2-(S)-(3,5-bis(tri- fluoromethyl)benzyloxy)-3-(R)-phenylmoφholine (from Example 33) in 1 mL of CH2CI2 was added. After stirring the mixture for 2 h, it was partitioned between water and CH2CI2. The organic layer was washed with water, brine and dried by filtering through Na2S04. The filtrate was concentrated and the residue was purified by flash chromatography using 70% EtOAc/hexane to furnish 152 mg (100 % yield) of the product. lH-NMR (400 MHz, CDCI3): δ 3.0-3.85 (m, 5H), 3.95 & 4.4 (br s, IH), 4.66 (d, J = 13 Hz, IH), 4.82 (d, J = 13 Hz, IH), 5.0 & 5.9 (br s, IH), 5.23 (s, IH), 7.1-7.65 (m, 7H), 7.8 (m, 3 H), 8.43 (br s, 2H). EXAMPLE 64 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(methoxycarbonylpentyl)- 3-(R)-phenylmoφholine To a solution of 0.259 g (0.64 mmol) of 2-(S)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(R)-phenylmoφholine (from example 33) in 2 mL of DMF were added 0.16 g (0.77 mmol) of methyl 6- bromohexanoate, 0.155 g (1.12 mmol) of K2CO3 and 2 crystals of nBu4NI. The resulting solution was heated in a 60°C bath for 36 h, at which time a tic indicated incomplete reaction. The bath temperature was raised to 100°C. After 3 h the reaction mixture was cooled and diluted with EtOAc. The EtOAc solution was washed with water (2x), brine and dried over Na2S04. The filtrate was concentrated and the residue was chromatographed using 30% EtOAc/hexane to isolate 220 mg (65%) of the product. lH-NMR (400 MHz, CDCI3): δ 1.0-1.4 (m, 4 H), 1.47 (m, J = 8 Hz, 2H), 1.95 (m, IH), 2.2 (t, J = 8 Hz, 2H), 2.35 (m, 2H), 2.9 (d, J = 13 Hz, IH), 3.07 (d, J = 7 Hz, IH), 3.62 (s, 3H), 3.81 (td, J = 8 Hz and 2 Hz, 1 H), 4.04 (dd, J = 10 Hz and 2 Hz, IH), 4.36 (d, J = 7 Hz, IH), 4.4 (d, J = 13 Hz, IH), 4.79 (d, J = 13 Hz, IH), 7.2-7.4 (m, 7H), 7.66 (s, IH). EXAMPLE 65 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(carboxypentyl)-3-(R)- phenylmorpholine A solution of 0.15 g (0.28 mmol) of 2-(S)-(3,5- Bis(trifluoromethyl)benzyloxy)-4-(methoxycarbonylpentyl)-3-(R)- phenylmoφholine (from Example 64) in 3 mL of MeOH was saponified by treating with 0.5 mL of 5 N NaOH for 40 min at 65°C. The solution was cooled, concentrated and the residue was diluted with water. The aqueous solution was adjusted to pH 6 by adding 2 N HCl and it was extracted with EtOAc. The organic layer was washed with brine, dried and concentrated. The residue upon chromatography on a flash column with 50% EtOAc/hexane furnished 0.13g (89%) of the product lH-NMR (400 MHz, CDCI3): δ 1.0-1.5 (m, 4H), 1.5 (m, 2H), 2.2 (m, 2H), 2.35 (m, 2H), 2.9 (d, J = 13 Hz, IH), 3.08 (d, J = 7 Hz, IH), 3.82 (t, J = 8 Hz, IH), 4.09 (d, J = 7 Hz, IH), 4.38 (s, IH), 4.4 (d, J = 13 Hz, IH), 4.79 (d, J = 13 Hz, IH), 7.2-7.4 (m, 7H), 7.66 (s, IH). EXAMPLE 66 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(methylaminocarbonyl- pentyl)-6-oxo-hexyl)-3-(R)-phenylmoφholine A solution of 116 mg (0.22 mmol) of 2-(S)-(3,5- Bis(trifluoromethyl)benzyloxy)-4-(carboxypentyl)3-(R)- phenylmoφholine (from Example 65) in 1 mL of CH2CI2 was treated with 40 mg (0.29 mmol) of HOBt, 57 mg (0.29 mmol) of EDC and 0.037 mL of N-methylmoφholine. After 10 min 0.027 mL (0.3 mmol) of aqueous methylamine (40%) was added and the resulting mixture was stirred for 4 h. The reaction mixture was diluted with water and extracted with CH2CI2. The combined CH2CI2 layer was washed with water, brine and dried over Na2S04, and the filtrate was concentrated. Purification of the residue on a flash column with EtOAc furnished 0.10 g of the product. lH-NMR (400 MHz, CDCI3): δ 1.0-1.4 (m, 4 H), 1.47 (m, 2H), 1.95 (m, IH), 2.04 (t, J = 8 Hz, 2H), 2.35 (m, 2H), 2. 74 (d, J = 5 Hz, 3 H), 2.89(d, J =12 Hz, IH) 3.08 (d, J = 7 Hz, IH), 3.81 (t, J = 7 Hz, IH), 4.02 (d, J = 11 Hz, IH), 4.36 (d, J = 7 Hz, IH), 4.39 (d, J = 13 Hz, IH), 4.79 (d, J =13 Hz, IH), 5.03 (br s, IH), 7.2-7.4 (m, 7H), 7.65 (s, IH). EXAMPLE 67 2-(R)-(3,5-Bis(trifluoromethyl)benzoyloxy)-3-(S)-phenyl-4-benzyl morpholine A solution of 2.67 g (10.0 mmol) of 3-(S)-phenyl-4-benzyl- 2-moφholinone (from Example 14) in 40 mL of dry THF was cooled to -78°C. The cold solution was treated with 12.5 mL of 1.0 M L- Selectride®, solution in THF, maintaining the internal reaction temperature below -70°C. Alternatively, only a 6% excess of L- Selectride® may be required. The resulting solution was stirred cold for 45 minutes and the reaction was charged with 3.60 mL (20.0 mmol) of 3,5-bis(trifluoro-methyl)benzoyl chloride. The resulting yellow mixture was stirred cold for 30 minutes and the reaction was quenched with 50 mL of saturated aqueous sodium bicarbonate solution. Alternatively, acetic acid may be used for the quench. The quenched mixture was partitioned between 300 mL of ether and 50 mL of water and the layers were separated. The organic layer was dried over magnesium sulfate. The aqueous layer was extracted with 300 mL of ether; the extract was dried and combined with the original organic layer. The combined organics were concentrated in vacuo. Flash chromatography on 150 g of silica gel using 37:3 v/v hexanes/ether as the eluant afforded 4.06 g (80%) of the title compound as a solid. lH NMR (CDC13, 200 MHz, ppm): δ 2.50 (dt, J= 3.4, 12.0, IH), 2.97 (app d, J= 12.0, IH), 2.99 (d, J= 13.6, IH), 3.72-3.79 (m, IH), 3.82 (d, J= 2.6, IH), 4.00 (d, J= 13.6, IH), 4.20 (dt, J= 2.4, 11.6), 6.22 (d, J= 2.6, IH), 7.22-7.37 (m, 7H), 7.57 (app d, J= 6.8, 2H), 8.07 (s, IH), 8.47 (s, 2H). Analysis Calcd for C26H21 F6NO3 : C, 61.29; H, 4.16; N, 2.75; F, 22.38. Found: C, 61.18; H, 4.14; N, 2.70; F, 22.13. EXAMPLE 68 2-(R)-(l-(3,5-Bis(trifluoromethyl)phenyl)ethenyloxy)-3-(S)-phenyl-4- benzyl morpholine Step A: Dimethyl titanocene A solution of 2.49 g (10.0 mmol) of titanocene dichloride in 50 mL of ether in the dark at 0°C was treated with 17.5 mL of 1.4 M methyllithium solution in ether maintaining the internal temperature below 5°C. The resulting yellow/orange mixture was stirred at room temperature for 30 minutes and the reaction was quenched by slowly adding 25 g of ice. The quenched reaction mixture was diluted with 50 mL of ether and 25 mL of water and the layers were separated. The organic layer was dried over magnesium sulfate and concentrated in vacuo to afford 2.03 g (98%) of the title compound as a light-sensitive solid. Alternatively, dimethyl titanocene may be prepared from methyl magnesium chloride. The dimethyl titanocene could be stored as a solution in toluene at 0°C for at least 2 weeks without apparent chemical degradation. lH NMR (CDC13, 200 MHz, ppm): δ -0.15 (s, 6H), 6.06 (s, 10H). Step B: 2-(R)-(l-(3,5-Bis(trifluoromethyl)phenyl)ethenyloxy)-3- (S)-phenyl-4-benzyl moφholine A solution of 2.50 g (4.9 mmol) of 2-(R)-(3,5-bis(tri- fluoro-methyl)benzoyloxy)-3-(S)-phenyl-4-benzyl moφholine (from Example 67) and 2.50 g (12.0 mmol) of dimethyl titanocene (from Example 68, Step A) in 35 mL of 1 :1 v/v THF/toluene was stirred in an oil bath at 80°C for 16 hours. The reaction mixture was cooled and concentrated in vacuo. Flash chromatography on 150 g of silica gel using 3:1 v/v hexanes/methylene chloride as the eluant afforded 1.71 g (69%) of the title compound as a solid. Alternatively, the product may be isolated by crystallization from methanol, following precipitation of titanium residues. Mass Spectrum (FAB): m/Z 508 (M+H, 25%). lH NMR (CDCI3, 400 MHz, ppm): δ 2.42 (dt, J= 3.6, 12.0, IH), 2.89 (app d, J= 11.6), 2.92 (d, J= 13.6, IH), 3.61-3.66 (m, IH), 3.73 (d, J= 2.8), IH), 4.00 (d, J= 13.6, IH), 4.09 (dt, J= 2.4, 11.6, IH), 4.75 (d, J= 2.8, IH), 4.79 (d, J= 2.8, IH), 5.36 (d, J= 2.4, IH), 7.23-7.41 (m, 7H), 7.63 (app d, J= 7.2, 2H), 7.79 (s, IH), 7.91 (s, 2H). Analysis Calcd for C27H23F6NO2: C, 63.90; H, 4.57; N, 2.76; F, 22.46. Found: C, 63.71; H, 4.53; N, 2.68; F, 22.66. EXAMPLE 69 2-(R)-(l-(S)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl moφholine and 2-(S)-(l -(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl moφholine A mixture of 1.50 g (2.9 mmol) of 2-(R)-(l-(3,5-bis(tri- fluoromethyl)phenyl)ethenyloxy)-3-(S)-phenyl-4-benzyl moφholine (from Example 68) and 750 mg 10% palladium on carbon catalyst in 25 mL of 3:2 v/v isopropanol/ethyl acetate was stirred under an atmosphere of hydrogen for 48 hours. Alternatively, the hydrogenation may be conducted using 5% palladium on alumina. The catalyst was filtered onto a pad of Celite; the reaction flask and filter pad were rinsed with 500 mL of ethyl acetate. The filtrate was concentrated in vacuo. Flash chromatography on 60 g of silica gel using 2:1 v/v hexanes/ether, then 2:1 v/v hexanes/ether afforded 106 mg of 2-(R)-(l- (S)-(3,5-bis(tri-fluoromethyl)phenyl)ethoxy)-3-(S)-phenyl moφholine and 899 mg of 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl moφholine, both as oils (84% total yield). For 2-(R)-(l-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl moφholine: Mass Spectrum (Cl): m/Z 420 (M+, 20%), 178 (100%). lH NMR (CDCI3, 400 MHz, ppm): δ 1.46 (d, J= 6.8), 1.92 (br s, IH), 3.13 (dd, J= 3.0, 12.6, IH), 3.24 (dt, J= 3.6, 12.6, IH), 3.62 (dd, J= 3.6, 11.2), 4.04 (d, J= 2.4, IH), 4.14 (dt, J= 3.0, 11.2, IH), 4.48 (d, J= 2.4, IH), 4.90 (q, J= 6.8, IH), 7.21-7.32 (m, 7H), 7.64 (s, IH). Analysis Calcd for C20H 19F6NO2: C, 57.28; H, 4.57; N, 3.34; F, 27.18. Found: C, 57.41; H, 4.61; N, 3.29; F, 27.23. EXAMPLE 70 2-(R)-(l-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4- (3-(5-oxo-1.2.4-triazolo)methylmoφholine Step A: 2-(R)-(l-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3- (S)-ρhenyl-4-(2-(N-methylcatboxy-acetamidrazono) morpholine A solution of 945 mg (2.3 mmol) of 2-(R)-(l-(R)-(3,5- bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl moφholine (from Example 69), 447 mg (2.7 mmol) of N-methylcarboxy-2-chloro- acetamidrazone (from Example 45, Step A), and 0.78 mL (4.5 mmol) of N,N-diisopropylethylamine in 17 mL of acetonitrile was stirred at room temperature for 20 hours. Alternatively, the alkylation may be conducted in dimethyl sulfoxide using potassium carbonate as a base. The reaction was concentrated m vacuo and the residue was partitioned between 50 mL of methylene chloride and 25 mL of water. The organic layer was separated, dried over magnesium sulfate and concentrated m vacuo. Flash chromatography on 50 g of silica gel using 50:1 :0.1 methylene chloride/methanol/ammonium hydroxide as the eluant afforded 1.12 g (90%) of the title compound as a foam. Step B: 2-(R)-( 1 -(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo- 1.2.4-triazolo)methylmoφholine A solution of 1.01 g (1.8 mmol) of 2-(R)-(l-(R)-(3,5- bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(2-(N-methyl- carboxyacetamidrazono)moφholine (from Example 70, Step A) in 15 mL of xylenes was heated at reflux for 2 hours. Diisopropylethylamine is optionally present. The reaction was cooled and concentrated in vacuo. Flash chromatography on 50 g of silica gel using 50:1:0.1 methylene chloride/methanol/ammonium hydroxide as the eluant afforded 781 mg (76%) of the title compound as a solid. The crude product may also be isolated directly upon cooling the reaction mixture. The purified product may be afforded by crystallization from hot methanol (charcoal decolorization) and water trituration. Mass Spectrum (FAB) m/Z 517 (M+H, 18%), 178 (100%). lH NMR (CDC13, 400 MHz, ppm): δ 1.47 (d, J= 6.8), 2.01-2.05 (m, 2H), 2.55 (dt, J= 3.6, 12.0, IH), 2.91 (d, J= 10.8, IH), 2.95 (d, J= 14.8, IH), 3.49 (d, J= 2.4, IH), 3.65 (d, J= 14.8, IH), 3.69 (d, J= 10.8, IH), 4.29 (dt, J= 2.4, 10.0), 4.38 (d, J= 2.8, IH), 4.88 (q, J= 6.8, IH), 7.14 (s, 2H), 7.33-7.40 (m, 5H), 7.62 (s, IH), 9.91 (br s, IH), 10.16 (br s, IH). Analysis Calcd for C23H22F6N4O3 : C, 53.49; H, 4.06; N, 10.85; F, 22.07. Found: C, 53.64; H, 4.33; N, 10.81; F, 22.27. EXAMPLE 71 2-(R)-(l-(S)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4- (3-(5-oxo- 1.2.4-triazolo)methylmoφholine The title compound was prepared in 32% yield from 2-(R)- (l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl moφholine (from Example 69) using a procedure analogous to Example 70. Mass Spectrum (FAB): m/Z 517 (M+H, 100%), 259 (50%). lH NMR (CDCI3, 400 MHz, ppm): δ 1.09 (d, J= 6.4, 3H), 2.47-2.53 (m, IH), 2.83 (app d, J= 11.6, IH), 2.95 (d, J= 14.0, IH), 3.51-3.65 (m, 3H), 4.01 (app t, J= 11.6, IH), 4.60 (q, J= 6.4, IH), 4.84 (d, J= 2.4, IH), 7.33-7.51 (m, 5H), 7.74 (s, 2H), 7.76 (s, IH), 9.51 (br s, IH), 10.00 (br s, IH). EXAMPLE 72 2-(R)-(3,5-Bis(trifluoromethyl)benzoyloxy)-3-(S)-(4-fluoro)phenyl-4- benzyl moφholine The title compound was prepared in 83% yield from 3-(R)- (4-fluoro)phenyl-4-benzyl-2-moφholinone (from Example 59) using a procedure analogous to Example 67. Mass Spectrum (FAB): m/Z 528 (M+H, 25%), 270 (100%). lH NMR (CDC13, 400 MHz, ppm): δ 2.50 (dt, J= 3.2, 12.0, IH), 2.96 (app d, J= 12.0, IH), 2.98 (d, J= 13.6, IH), 3.74-3.78 (m, IH), 3.81 (d, J= 2.8, IH), 3.94 (d, J= 13.6, IH), 4.19 (dt, J= 2.0, 12.0), 6.20 (d, J= 2.8, IH), 6.99 (t, J= 8.4, 2H), 7.27-7.38 (m, 5H), 7.52-7.56 (m, 2H), 8.09 (s, IH), 8.46 (s, 2H). EXAMPLE 73 2-(R)-(l-(3,5-Bis(trifluoromethyl)phenyl)ethenyloxy)-3-(S) phenyl-4-benzyl moφholine The title compound was prepared in 60% yield from 2-(R)- (3,5-bis(trifluoromethyl)benzoyloxy)-3-(S)-(4-fluoro)phenyl-4-benzyl moφholine (Example 72) using a procedure analogous to Example 68. Mass Spectrum (FAB): m/Z 526 (M+H, 75%), 270 (100%). lH NMR (CDC13, 400 MHz, ppm): δ 2.42 (dt, J= 3.6, 12.0), 2.90 (app d, J= 12.0, IH), 2.91 (d, J= 13.6, IH), 3.62-3.66 (m, IH), 3.72 (d, J= 2.6), 3.94 (d, J= 13.6, IH), 4.09 (dt, J= 2.4, 12.0, IH), 4.75 (d, J= 3.2, IH), 4.82 (d, J= 3.2, IH), 5.32 (d, J= 2.6, IH), 7.09 (t, J= 8.8, 2H), 7.24-7.33 (m, 5H), 7.58-7.62 (m, 2H), 7.80 (s, IH), 7.90 (s, 2H). EXAMPLE 74 2-(R)-(l-(S)-(3,5-Bis(trifluoromethyl)ρhenyl)ethoxy)-3-(S)-(4- fluoro)phenyl moφholine and 2-(S)-(l-(R)-(3,5-Bis(trifluoromethyl)- phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl moφholine A mixture of 1.83 g (3.5 mmol) of 2-(R)-(l-(3,5-bis(tri- fluoromethyl)phenyl)ethenyloxy)-3-(S)-(4-fluoro)phenyl-4-benzyl moφholine (from Example 73) and 800 mg 5% rhodium on alumina catalyst in 40 mL of absolute ethanol was stirred under an atmosphere of hydrogen for 24 hours. The catalyst was filtered onto a pad of Celite; the reaction flask and filter cake were rinsed with 200 mL of ethyl acetate. The filtrate was concentrated in vacuo and the residue was pumped under high vacuum (1 mmHg, room temperature) to dryness. The residue was redissolved in 40 mL of isopropanol; 800 mg of 10% palladium on carbon catalyst was added and the resulting mixture was stirred under an atmosphere of hydrogen for 24 hours. The catalyst was filtered onto a pad of Celite; the reaction flask and filter cake were rinsed with 200 mL of ethyl acetate. The filtrate was concentrated in vacuo. Flash chromatography on 50 g of silica gel using 2:1 v/v hexanes/ether, then 3:2 v/v ether/hexanes as the eluant afforded 283 mg of 2-(R)-(l-(S)-(3,5-bis(trifluoromethyl)phenyl)- ethoxy)-3-(S)-(4-fluoro)phenyl moφholine and 763 mg of 2-(R)-(l- (R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl moφholine, both as oils (total yield 68%). For 2-(R)-(l-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl moφholine: Mass Spectrum (FAB) m/Z 438 (M+H, 65%), 180 (100%). lH NMR (CDC13, 400 MHz, ppm): δ 1.47 (d, J= 6.8, 3H), 1.87 (br s, IH), 3.03 (dd, J= 2.8, 12.8), 3.17 (dt, J= 4.0, 12.4, IH), 3.43-3.47 (m, IH), 3.80 (dt, J= 3.2, 11.6), 4.10 (d, J= 2.2, IH), 4.70 (q, J= 6.8, IH), 4.87 (d, J= 2.2, IH), 6.99-7.03 (m, 2H), 7.23-7.27 (m, 2H), 7.63 (s, 2H), 7.66 (s, IH). For 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl moφholine: Mass Spectrum (FAB) m/Z 438 (M+H, 75%), 180 (100%). lH NMR (CDC13, 400 MHz, ppm): δ 1.16 (d, J= 6.8), 1.80 (br s, IH), 3.13 (dd, J= 3.2, 12.4), 3.23 (dt, J= 3.6, 12.4), 3.63 (dd, J= 2.4, 11.2), 4.01 (d, J= 2.4, IH), 4.13 (dt, J= 3.2, 12.0), 4.42 (d, J= 2.4, IH), 4.19 (q, J= 6.8, IH), 7.04-7.09 (m, 2H), 7.27-7.40 (m, 4H), 7.73 (s, IH). EXAMPLE 75 2-(R)-(l-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)- phenyl-4-(3-(5-oxo-1.2.4-triazolo)methylmoφholine The title compound was prepared in 79% yield from 2-(R)- (l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl moφholine (from Example 74) using a procedure anaolgous to Example 70. Mass Spectrum (FAB): m/Z 535 (M+H, 100%), 277 (60%). lH NMR (CDC13 + CD3OD, 400 MHz, ppm): δ 1.48 (d, J= 6.8, 3H), 2.52 (app t, J= 10.4, IH), 2.85-2.88 (m, 2H), 3.47 (d, J= 2.8, IH), 3.63 (d, J= 14.4, IH), 3.70 (dd, J= 2.0, 11.6, IH), 4.24 (app t, J= 10.8, IH), 4.35 (d, J= 2.8, IH), 4.91 (q, J= 6.8, IH), 7.07 (app t, J= 8.4, 2H), 7.15 (s, 2H), 7.37-7.40 (m, 2H), 7.65 (s, IH). Analysis Calcd for C23H21 F7N4O3 : C, 51.69; H, 3.96; N, 10.48; F, 24.88. Found: C, 51.74; H, 4.04; N, 10.50; F, 24.59. EXAMPLE 76 2-(R)-(l-(S)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)- phenyl-4-(3-(5-oxo-1.2.4-triazolo)methylmoφholine The title compound was prepared in 60% yield from 2-(R)- (l-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl moφholine (from Example 74) using a procedure anaolgous to Example 70. Mass Spectrum (FAB): m/Z 535 (M+H, 50%), 293 (100%). H NMR (CDC13 + CD3OD, 400 MHz, ppm): δ 1.11 (d, J= 6.4, 3H), 2.49 (dt, J= 2.4, 11.2), 2.83 (app d, J= 11.2, IH), 2.95 (d, J= 14.4, IH), 2.48-2.58 (m, 3H), 3.99 (app t, J= 9.6, IH), 4.61 (q, J= 6.4, IH), 4.81 (d, J= 2.4, IH), 7.09 (t, J= 8.8, 2H), 7.50-7.53 (m, 2H), 7.75 (app s, 3H), 10.40 (br s, IH), 11.00 (br s, IH). EXAMPLE 77 2-(R)-(l-(R)-(3-(Trifluoromethyl)phenyl)ethoxy)-3- oxo- 1.2.4-triazolo)methylmoφholine Step A: 2-(R)-(l-(R)-(3-(Trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl moφholine The title compound was prepared in 25% yield from 3- (S)-ρhenyl-4-benzyl-2-moφholinone (from Example 14) using procedures anaolgous to Examples 67-69. !H NMR (CDC13, 400 MHz, ppm): δ 1.39 (d, J= 6.6, 3H), 1.93 (br s, IH), 3.10 (dd, J= 3.0, 12.7, IH), 3.20 (dt, J= 3.6, 12.4, IH), 3.58 (ddd, J= 1.1, 3.8, 11.2, IH), 4.00 (d, J= 2.4, IH), 4.12 (dt, J= 3.0, 11.2, IH), 4.44 (d, J= 2.4, IH), 4.79 (q, J= 6.6, IH), 6.72 (d, J=7.7, IH), 7.01 (s, IH), 7.09 (t, J=7.7, IH), 7.18-7.25 (m, 2H), 7.25-7.3 (m, 3H), 7.34 (d, J=7.7, IH). Analysis: Calcd for Cl9Hl9F3Niθ2: C-65.14 H-5.47 N-4.00 F-16.27 Found: C-64.89 H-5.73 N-3.83 F-15.95 Step B: 2-(R)-(l-(R)-(3-(Trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1.2.4-triazolo)methylmoφholine The title compound was prepared in 90% yield from 2- (R)-(l-(R)-(3-(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl moφholine (from Example 77, Step A) using a procedure anaolgous to Example 70. H NMR (CDC13, 400 MHz, ppm): δ 1.40 (d, J= 6.3, 3H), 2.53 (br t, J=11.2, IH), 2.86 (app d, J= 12.2, IH), 2.94 (d, J= 14.3, IH), 3.44 (br s, IH), 3.63 (br d, J=14, 2H), 4.27 (app t, J= 11.5, IH), 4.34 (d, J=2.1 , IH), 4.76 (q, J= 6.7, IH), 6.63 (d, J=7.7, IH), 6.93 (s, IH), 7.06 (t, J= 7.6, IH), 7.25-7.45 (m, 6H), 9.63 (br s, IH), 9.74 (br s, IH). Analysis: Calcd for C22H22F3N4O3: C-59.06 H-4.96 N-12.52 F-12.74 Found: C-58.84 H-5.17 N-12.37 F-12.50 EXAMPLE 78 2-(R)-(l-(R)-(3-(Fluoro)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3 -(5-oxo- 1.2.4-triazolo)methylmoφholine Step A: 2-(R)-(l -(R)-(3-(Fluoro)-5-(trifluoromethyl)phenyl)- ethoxy)-3-(S)-phenyl-moφholine The title compound was prepared in 44% yield from 3- (S)-phenyl-4-benzyl-2-moφholinone (from Example 14) using procedures anaolgous to Examples 67-69. lH NMR (CDC13, 400 MHz, ppm): δ 1.38 (d, J= 6.6, 3H), 1.90 (br s, IH), 3.17 (dd, J= 3.0, 12.7, IH), 3.18 (dt, J= 3.6, 12.7, IH), 3.58 (ddd, J= 1.1, 3.8, 11.2, IH), 4.02 (d, J= 2.3, IH), 4.11 (dt, J= 3.0, 11.2, IH), 4.44 (d, J= 2.3, IH), 4.78 (q, J= 6.6, IH), 6.29 (d, J=9.2, IH), 6.85 (s, IH), 7.03 (d, J=8.4, IH), 7.18-7.26 (m, 2H), 7.26-7.3 (m, 3H). Analysis: Calcd for C19H18F4N1O2: C-61.95 H-4.93 N-3.80 F-20.63 Found: C-61.78 H-5.14 N-3.71 F-20.35 Step B: 2-(R)-(l -(R)-(3-(Fluoro)-5-(trifluoromethyl)phenyl)- ethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methy 1- moφholine The title compound was prepared in 77% yield from 2- (R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl moφholine (from Example 78, Step A) using a procedure anaolgous to Example 70. lH NMR (CDCI3, 400 MHz, ppm): δ 1.40 (d, J= 6.3, 3H), 2.54 (br t, J=l l, IH), 2.87 (app d, J= 12, IH), 2.94 (app d, J= 14, IH), 3.47 (br s, IH), 3.63 (br t, J=14, 2H), 4.25 (app t, J= 11, IH), 4.35 (d, J=1.5, IH), 4.75 (q, J= 6.3, IH), 6.62 (d, J=6.7, IH), 6.78 (s, IH), 7.01 (d J= 8.4, IH), 7.24 (d, J=3.9, IH), 7.35 (br s, 4H), 9.61 (br s, IH), 9.89 (br s, IH). Analysis: Calcd for C22H21F4N4O3: C-56.77 H-4.55 N-12.04 F-16.33 Found: C-56.57 H-4.65 N- 11.94 F-16.13 EXAMPLE 79 2-(S)-(3-Fluoro-5-trifluoromethyl)benzoyloxy)-3-(S)-(4-fluoro)phenyl- 4-benzyl moφholine The title compound was prepared in 57% yield from 3-(S)- (4-fluoro)phenyl-4-benzyl-2-moφholinone (from Example 59) using a procedure analogous to Example 67. Mass Spectrum (Cl): m/Z 478 (M+H, 100%) H NMR (CDCI3, 360 MHz, ppm): δ 2.50 (dt, J= 3.3, 12.0, IH), 2.96(d, J= 12.0, IH), 2.98 (d, J= 13.6, IH), 3.75 (dd,J= 1.7, 11.5, IH), 3.80 (d, J= 13.6, IH), 3.75 (dd, J=1.7, 11.5, IH), 3.80 (d, J= 2.5, IH), 3.92 (d, J= 13.6, IH), 4.19 (dt, J= 2.1, 12.0, IH), 6.20 (d,J= 2.5, IH), 6.99 (t, J= 8.7, 2H), 7.2-7.37 (m, 5H), 7.51-7.55 (m, 3H), 7.89 (d, J= 8.4, IH), 8.09 (s, IH). EXAMPLE 80 2-(S)-(l-(3-Fluoro-5-trifluoromethyl)phenyl)ethenyloxy)-3-(S)-(4- fluoro)-phenyl-4-benzyl moφholine The title compound was prepared in 85% yield from 2-(S)-(3- fluoro-5-trifluoromethyl)benzoyloxy)-3-(S)-(4-fluoro)phenyl-4-benzyl moφholine (from Example 79) using a procedure analogous to Example 68. Mass Spectrum (Cl): m/Z 476 (M+H, 100%) H NMR (CDCI3, 360 MHz, ppm): δ 2.42 (dt, J= 3.6, 12.0 Hz, IH), 2.90 (d, J= 12.0, IH), 2.91 (d, J=13.6, IH), 3.60-3.62 (m, IH), 3.72 (d, J= 2.6, IH), 3.92 (d, J= 13.6, IH), 4.09 (dt, J= 2.4, 12.0, IH), 4.67 (d, J= 2.9, IH) 4.76 (d, J= 2.9, IH), 5.28 (d, J= 2.6, IH), 7.07 (t, J=8.7, 2H), 7.2-7.37 (m, 7H), 7.53 (s, IH), 7.57-7.61 (m, 2H). EX AMPLE 81 2-(S)-(l-(S)-(3-Fluoro-5-trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl moφholine and 2-(S)-(l-(R)-(3-Fluoro-5- trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl moφholine The title compounds were prepared from 2-(S)-(l-(3- fluoro-5-trifluoromethyl)ρhenyl) ethenyloxy)-3-(S)-(4-fluoro)-phenyl- 4-benzyl moφholine (from Example 80) using a procedure analogus to Example 74, but using 10% palladium on charcoal as the catalyst. For 2-(S)-(l -(S)-(3-Fluoro-5-trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl moφholine: Mass Spectrum (Cl): m/Z 388 (M+H, 100%) lH NMR (CDC13, 360 MHz, ppm): δ 1.12 (d, J= 6.5, 1H),1.83 (s, IH), 3.02 (d, J=10.1, IH), 3.16 (dt, J= 3.6,12.5, IH), 3.43 (dd, J= 2.7, 11.4, IH), 3.81 (dt, J= 2.9, 11.7, IH), 4.09 (d, J=2.1, IH), 4.62 (q, J= 6.5, IH), 4.84 (d, J= 2.1 , IH), 7.05 (t, J= 8.8, 2H), 7.2 (d, J= 8.8, 2H), 7.32 (s, IH), 7.38 (dd, J= 5.5, 8.5, 2H). For 2-(S)-(l -(R)-(3-Fluoro-5-trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl moφholine: Mass Spectrum (Cl): m/Z 387 (M+, 100%) lH NMR (CDC13, 360 MHz, ppm): δ 1.42 (d, J= 6.6, 3H), 1.91 (s, IH), 3.11 (dd, J= 3.2, 12.4, IH), 3.22 (dt, J= 3.6, 12.4, IH), 3.58-3.62 (m, IH), 4.01 (d, J= 2.3, IH), 4.1 1 (dt, J= 3.2, 12.0, IH), 4.41 (d, J= 2.3, IH), 4.80 (q, J= 6.6, IH), 6.41 (d, J= 9.2, IH), 6.86 (s, IH), 7.02 (t, J= 8.7, 2H), 7.08 (d, J= 9.2, 2H), 7.21-7.26 (m, 2H). EXAMPLE 82 2-(S)-(l-(R)-(3-Fluoro-5-trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-l .2.4-triazolo)methyl moφholine The title compound was prepared from 2-(S)-(l-(R)-(3-fluoro-5- trifluoromethyl) phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl moφholine (from Example 81) using a procedure analogous to Example 70, mp 209-211 °C. [α]D = +65.1 (c = 1.0, methanol) lH NMR (CDC13, 360 MHz, ppm): δ 1.32 (d, J= 6.4, IH), 2.38 (t, J= 11.9, IH), 2.76 (d, J= 13.9, IH), 2.84 (d, J= 11.5, IH), 3.32 (s, IH), 3.40 (d, J=13.9, IH), 3.49 (s, IH), 3.61 (d, J= 11.2, IH), 4.11 (t, J=11.3, IH), 4.8 (q, J=6.4, IH), 6.57 (d, J= 9.4, IH), 6.94 (s, IH), 7.1 (t, J= 8.7, 2H), 7.39. (d, J= 8.7, 2H), 7.51 (s, 2H), 11.26 (s, IH), 11.38 (s, IH). EXAMPLE 83 2-(S)-(l-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l .3-imidazolo)methyl moφholine Step A: N.N-Diacetyl-4-bromomethyl-2-imidazolone The title compound was prepared according to the procedure of Dolan and Dushinsky (Journal of the American Chemical Society. 70, 657 (1948)). Step B: 2-(S)-(l-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl- moφholine A mixture of 1.00 g (2.28 mmol) of 2-(S)-(l-(R)-(3,5- bis(trifluoro-methyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl moφholine (from Example 74), 0.62 g (2.40 mmol) of N,N-diacetyl-4- bromometh l-2-imidazolone (from Example 83, Step A) and 0.63 g (4.56 mmol) of potassium carbonate in 10 mL of N,N-dimethyl- formamide was stirred at room temperature for 15 minutes. The reaction was diluted with 100 mL of ethyl acetate and washed with water, saturated aqueous sodium chloride solution, dried over magnesium sulfate, and evaporated in vacuo. The resulting oil was dissolved in 10 mL of ethanol; the resulting solution was treated with 1.05 mL of 33% ethanolic methy lamine solution and stirred at room temperature for 10 minutes. The reaction mixture was concentrated in vacuo to afford a solid. Recrystallisation from ethyl acetate/methanol afforded 0.63 g of the title compound, mp 192-194 °C. lH NMR (d6-DMSO, 360 MHz, ppm): δ 1.35 (d, J= 6.5, 3H), 2.25 (dt, J=8.7, IH), 2.60 (d, J= 13.8, IH), 2.89 (d, J=11.6, IH), 3.28-3.36 (m, 2H), 3.62 (d, J=10.2, IH), 4.1 (t, J=10.0, IH), 4.31 (d, J= 2.7, IH), 4.92 (q, J= 6.5, IH), 5.97 (s, IH), 7.06 (t, J= 8.8, 2H), 7.36 (s, 2H), 7.65- 7.85 (m, 2H), 7.84 (s, IH), 9.58 (s, IH), 9.8 (s, IH). EXAMPLE 84 2-(S)-(l-(R)-(3-Fluoro-5-(trifluoromethyl)phenyl)ethoxy-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l .3-imidazolo)methyl moφholine The title compound was prepared from 2-(S)-(l-(R)-(3-fluoro-5- trifluoromethyl) phenyl)ethoxy)-3-(S)-(4-fluo.ro)phenyl moφholine (from Example 82) using a procedure analogous to Example 83, mp 209-210 °C. [α]D = +92.8 (c = 1.0 , methanol). lH NMR (d6-DMSO, 360 MHz, ppm) δ 1.31 (d, J= 6.5, 3H), 2.24 (dt, J= 3.0, 11.9, IH), 2.6 (d, J= 13.9, IH), 3.61 (d, J= 11.2, IH), 4.1 (t, J= 11.0, IH), 4.29 (d, J= 2.3, IH), 4.8 (q, J= 6.5, IH), 6.00 (s, IH), 6.55 (d, J= 9.3, IH), 6.94 (s, IH), 7.11 (t, J= 8.7, 2H), 7.39 (d, J= 8.4, IH), 7.51 (s, 2H), 9.59 (s, IH), 9.84 (s, IH). EXAMPLE 85 2-(S)-(l-(S)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(R)-(4- fluorophen yl)-4-(3-(5-oxo- 1 H.4H- 1.2.4-triazolo)methylmoφholine The title compound was prepared from (R)-(4- fluoro)phenylglycine using procedures anlogous to Example 59, 67, 68, 69 and 70. [α]D = -67.7 (c = 0.7, MeOH, 20 °C) EXAMPLE 86 The following compounds are prepared from 3-(S)-phenyl-4- benzyl-2-moφholinone (from Example 14) or 3-(S)-(4-fluoro)phenyl- 4-benzyl-2-moφholinone (from Example 59) using procedures analogous to Examples 15, 67 - 69 and 74. The hydrogenation of the 1- (substituted-aryl)ethenyloxy intermediates may be done with 10% palladium on carbon (Example 70) or 5% rhodium on alumina catalyst (Example 74) to give rapid reduction of the enol ether. Removal of the 4-benzyl substituent may be done catalytically under extended hydrogenation with 10% palladium on carbon or 5% rhodium on alumina catalyst or (when dehalogenation or cleavage of the ether might occur) in a second step with 1-chloroethyl chloroformate as in Example 44, Step C. 1) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-moφholine; 2) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 3) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 4) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 5) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 6) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 7) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-moφholine; 8) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl -moφholine; 9) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 10) 2-(R)-(l-(R)-(3-(t-butyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-moφholine; 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-moφholine 2-(R)-(l-(R)-(3,5- ( dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-moφholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-phenyl-moφholine; 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 2-(R)-( 1 -(R)-( 1 -(naphthyl)ethoxy)-3 -(S)-phenyl-moφholine; 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 2-(R)-(l -(R)-(l -(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-moφholine; 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl- moφholine; 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-( 1 -(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-moφholine; 8 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 9 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl- moφholine; 30 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-moφholine; 31 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenvlethoxy)-3-(S)- pheny 1-moφholine ; 2 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-moφholine; 33 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-moφholine; 34 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)ρhenyl-moφholine; 35 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-moφholine; 36 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 37 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-moφholine; 38 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 39 2-(R)-(l -(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-moφholine; 0 2-(R)-( 1 -(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 41 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-moφholine; 42 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 43 2-(R)-( 1 -(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-moφholine; 44 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 45 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-moφholine; 46 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)ρhenyl- moφholine; 47 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-moφholine; 48 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 49 2-(R)-(l-(R)-(3-(thiomethyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 50) 2-(R)-(l-(R)-(3-(thiomethyl)-5-(trifluoromethyl)phenyl)ethoxy)- 3 -(S)-phenyl-moφholine; 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyl-moφholine; 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl- moφholine ; 2-(R)-(l-(R)-(3-(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S )-(4-fluoro)pheny 1-moφholine ; 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3-(t-butyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l -(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l -(R)-(l -(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)ρhenyl-moφholine; 2-(R)-(l-(R)-(3-(thiomethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-mθφholine; 2-(R)-(l-(R)-(3-(thiomethyl)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-moφholine; 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)ρhenyl-moφholine; 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-moφholine; 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-moφholine; 2-(R)-( 1 -(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-moφholine; 86) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 87) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-moφholine; 88) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 89) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-moφholine; 90) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-moφholine; 91) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-moφholine; 92) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethy phenyl-moφholine; 93) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-moφholine; 94) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-moφholine. EXAMPLE 87 The following compounds are prepared from the corresponding 2-(S)-(substituted-benzyloxy)-3-(S)-aryl moφholines or 2-(R)-(l-(R)- (substituted-aryl)ethoxy)-3-(S)-aryl moφholines (from Example 86) using procedures analogous to Examples 17, 18, 36, 38, 83 or, in the case of the 4-(5-tetrazolyl)methyl-substituted moφholines, by alkylation of the moφholine (from Example 86) with chloroacetonitrile in the presence of a tertiary amine base in acetonitrile, followed by formation of the final product by reacting the resulting nitrile with either sodium azide or trimethylsilylazide in an appropriate solvent. 1) 2-(R)-(l-(R)-(3-(Chloro)-5-(trifluoromethylphenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 2) 2-(R)-(l-(R)-(3,5-(Dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- l,2,4-triazolo)methyl-moφholine; 3) 2-(R)-(l-(R)-(3-(Fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 4) 2-(R)-(l-(R)-(3-(Chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 5) 2-(R)-(l-(R)-(3-(Bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(5-oxo-l,2,4-triazolo)methyl -moφholine; 6) 2-(R)-(l-(R)-(3-(Isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- l,2,4-triazolo)methyl-moφholine; 7) 2-(R)-(l-(R)-(3-(Isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 8) 2-(R)-(l-(R)-(3-(Chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 9) 2-(R)-(l-(R)-(3-(Fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl -moφholine; 10) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-4-(3-(- 1 ,2,4-triazolo)methyl-moφholine; 11 ) 2-(R)-(l -(R)-(3-(t-Butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 12) 2-(R)-(l-(R)-(3-(t-Butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 13) 2-(R)-(l-(R)-(3,5-(Dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 14) 2-(R)-(l-(R)-(3,5-(Dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 15) 2-(R)-(l-(R)-(3,5-Bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 16) 2-(R)-(l -(R)-(3,5-Bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 17) 2-(R)-(l-(R)-(3,5-(Dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- l,2,4-triazolo)methyl-moφholine; 18) 2-(R)-(l-(R)-(3,5-(Difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 19) 2-(R)-(l-(R)-(l-(Naphthyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 20) 2-(R)-(l-(R)-(l-(4-(Fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- l,2,4-triazolo)methyl-moφholine; 21) 2-(R)-(l-(R)-(l-(3-(Fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1 ,2,4-triazolo)methy 1-moφholine; 22) 2-(R)-(l -(R)-(l -(3-(Chloro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 23) 2-(R)-(l-(R)-(l-(3-(Methyl)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 24) 2-(R)-(l-(R)-(l-(3-(Trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-l ,2,4-triazolo)methyl-moφholine; 25) 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl-moφholine; 26) 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl-moφholine; 27) 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 28) 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 29) 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- (5-oxo- 1 ,2,4- triazolo)methyl-moφholine; 30) 2-(S)-(2-Fiuoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 31) 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(5-oxo-l ,2,4-triazolo)methyl-moφholine; 32) 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 33) 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl-moφholine; 34) 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l ,3-imidazolo)methyl-moφholine; 35) 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-(2-oxo-l ,3-imidazolo)methyl-moφholine; 36) 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-(2-oxo-l ,3-imidazolo)methyl -moφholine; 37 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 38 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 39 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-imidazolo)methyl-moφholine; 40 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 41 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 42 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 43 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-imidazolo)methyl-moφholine; 44 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 45 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 46 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 47 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(5-tetrazolo)methyl-moφholine; 48 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 49 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- oxo-5H-pyrrol-4-yl)methyl-moφholine; 50 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 51 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 52 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 53 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl-moφholine; 54) 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)ρhenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 55) 2-(R)-(l-(R)-(2-Chloro-5-trifluoromemyl)phenylethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 56) 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)ρhenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 57) 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- (5-oxo- l,2,4-triazolo)methyl-moφholine; 58) 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 59) 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 60) 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 61) 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-ρhenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methy 1-moφholine; 62) 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl-moφholine; 63) 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-(2-oxo-l ,3-imidazolo)methyl-moφholine; 64) 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 65) 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 66) 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 67) 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-imidazolo)methyl-moφholine; 68) 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 69) 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 70) 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(5-tetrazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- oxo-5H-pyrrol-4-yl)methyl-moφholine; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 2-(S)-(3-Methyl)benzyloxy-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 2-(S)-(3-Methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 2-(R)-(l -(R)-(3-Methyl)phenylethoxy)-3-(S)-phenyl-4-(3-(l ,2,4- triazolo)methyl-moφholine; 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl-moφholine; 2-(S)-(3-Methyl)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo-T ,2,4- triazolo)methyl-moφholine; 2-(S)-(3-Methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 87 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 2-(S)-(3-Methyl)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo-l,3- imidazolo)methyl-moφholine; 2-(S)-(3-Methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 2-(S)-(3-Methyl)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 2-(S)-(3-Methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine; 2-(S)-(3-Methyl)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 2-(S)-(3-Methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 100) 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 101) 2-(S)-(3-Methyl)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholine; 102) 2-(S)-(3-Methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 103) 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 104) 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-moφholine; 105) 2-(S)-(3-Methyl)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- yl)methyl-moφholine; 106) 2-(S)-(3-Methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 107) 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 108) 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 109) 2-(S)-(3-Bromo)benzyloxy-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 110) 2-(S)-(3-Bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(l ,2,4- triazolo)methyl-moφholine; 111) 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 112) 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl-moφholine; 113) 2-(S)-(3-Bromo)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo- 1,2,4- triazolo)methyl-moφholine; 114) 2-(S)-(3-Bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 115) 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 116) 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 117) 2-(S)-(3-Bromo)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo-l ,3- imidazolo)methyl-moφholine; 118) 2-(S)-(3-Bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 119) 2-(R)-(l -(R)-(3-Bromo)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 120) 2-(R)-( 1 -(R)-(3-Bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 121) 2-(S)-(3-Bromo)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 122 2-(S)-(3-Bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 123 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 124 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine; 125 2-(S)-(3-Bromo)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 126 2-(S)-(3-Bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 127 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 128 2-(R)-( 1 -(R)-(3-Bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 129 2-(S)-(3-Bromo)benzyloxy-3-(S)-phenyi-4-(5-tetrazolo)methyl- moφholine; 130 2-(S)-(3-Bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 131 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 132 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5 -tetrazolo)methy 1-moφholine ; 133 2-(S)-(3-Bromo)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- yl)methyl-moφholine; 134 2-(S)-(3-Bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 135 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 136 2-(R)-( 1 -(R)-(3-Bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 137 2-(S)-(3-Chloro)benzyloxy-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 138 2-(S)-(3-Chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 139 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 140 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl-moφholine; 141 2-(S)-(3-Chloro)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo- 1 ,2,4- triazolo)methyl-moφholine; 142 2-(S)-(3-Chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 143 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 144 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 145 2-(S)-(3-Chloro)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo-l ,3- imidazolo)methyl-moφholine; 146 2-(S)-(3-Chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 147 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 148 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-(^-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 149 2-(S)-(3-Chloro)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 150 2-(S)-(3-Chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 151 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 152 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine; 153 2-(S)-(3-Chloro)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 154 2-(S)-(3-Chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 155 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 156) 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 157) 2-(S)-(3-Chloro)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholine; 158) 2-(S)-(3-Chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 159) 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 160) 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5 -tetrazolo)methy 1-moφholine ; 161) 2-(S)-(3-Chloro)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- y l)methy 1-moφholine ; 162) 2-(S)-(3-Chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 163) 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 164) 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 165) 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methylmoφholine; 166) 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3- (l,2,4-triazolo)methyl-moφholine; 167) 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (3-(l ,2,4-triazolo)methyl-moφholine; 168) 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 169) 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 170) 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3- (5-oxo- l,2,4-triazolo)methyl-moφholine; 171) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 172) 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)ρhenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (2-imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (4-imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)ρhenyl-4-(4-imidazolo)methyl-moφholine; 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (5-tetrazolo)methyl-moφholine; 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 190 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- oxo-5H-pyrrol-4-yl)methyl-moφholine; 191 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 192 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 193 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 194 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 195 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-phenyl-4-(3-( 1 ,2,4- triazolo)methyl-moφholine; 196 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl-moφholine; 197 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo-l,2,4- triazolo)methyl-moφholine; 198 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 199 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 200 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 201 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo-l,3- imidazolo)methyl-moφholine; 202 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 203 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 204 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl -moφholine; 205 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 206 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 207 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 208 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine; 209 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 210 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 211 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 212 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 213 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholine; 214 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 215 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 216 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-moφholine; 217 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- y l)methy 1-moφholine ; 218 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 219 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 220 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 221 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo- 1 ,2,4-triazolo)methy 1-moφholine; 222 2-(R)-( 1 -(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-pheny l-4-(3- (1 ,2,4-triazolo)methyl-moφholine; 223 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(3-(2- oxo- 1 ,3-imidazolo)methyl-moφholine; 224) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 225) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 226) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-.4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 227) 2-(R)-(l -(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 ,2,4- triazolo)methyl-moφholine; 228) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 229) 2-(R)-(l -(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyl-4-(3-(2-oxo- 1 ,3- imidazolo)methyl-moφholine; 230) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 231) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- ( 1 ,2,4-triazolo)methy 1-moφholine; 232) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (2-oxo- 1 ,3-imidazolo)methyl-moφholine; 233) 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methy 1-moφholine; 234) 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 235) 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 236) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 237) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl-moφholine; 238) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo-l ,3-imidazolo)methyl-moφholine; 239 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3 -(S)-(4- fluoro)phenyl-4-(3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 240 2-(R)-(l-(R) (3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)ρhenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 241 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 242 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)ρhenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 243 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)ρhenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 244 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 245 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 246 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 247 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 248 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 249 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 250 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 251 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 252 2-(R)-(l-(R)-(3-(isoproρoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 253 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 254 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)ρhenyl)ethoxy)- 3-(S)-(4-fluoro)pheny l-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl- moφholine; 255 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 256 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl- moφholine; 257 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 258 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 259 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo-l ,3-imidazolo)methyl-moφholine; 260 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 261 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl-moφholine; 262 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 263 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 264 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl-moφholine; 265 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 266 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(3-(5-oxo-l,2,4-triazolo)methyl- moφholine; 267 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 268 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl- moφholine; 269 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)ρhenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 270 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 271 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 272 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 273 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 274 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo-l ,3-imidazolo)methyl-moφholine; 275 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-l,2,4-triazolo)methyl- moφholine; 276 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 277 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl- moφholine; 278 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl- moφholine; 279 2-(R)-( 1 -(R)-(3 ,5-bis(trifluoromethy l)-4-(chloro)pheny l)ethoxy )- 3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 280 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl- moφholine; 281 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 282 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 283 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 284 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-l ,2,4-triazolo)methyl-moφholine; 285 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 286 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 287 2-(R)-(l -(R)-(l -(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3- (5-oxo- l,2,4-triazolo)methyl-moφholine; 288 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3- (l,2,4-triazolo)methyl-moφholine; 289 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3- (2-oxo- 1 ,3-imidazolo)methy 1-moφholine; 290 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 291 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 292 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 293 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 294 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 295 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 296 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 297 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 298 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 299 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 300 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 301 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3 -(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 302) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 303) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 304) 2-(R)-(l -(R)-(l -(3-(trifluoromethyl)naphιhyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 305) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-l ,2,4-triazolo)methyl-moφholine; 306) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl-moφholine; 307) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 308) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl- moφholine; 309) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 310) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(2-oxo-l ,3-imidazolo)methyl- moφholine; 311) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5- oxo- 1 ,2,4-triazolo)methyl-moφholine; 312) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3- (1 ,2,4-triazolo)methyl-moφholine; 313) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(2- oxo- 1 ,3-imidazolo)methyl-moφholine; 314) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 315) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 316 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 317 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-l,2,4- triazolo)methyl-moφholine; 318 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(3-(l ,2,4- triazolo)methyl-moφholine; 319 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(3-(2-oxo-l,3- imidazolo)methyl-moφholine; 320 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5- oxo- 1 ,2,4-triazolo)methyl-moφholine; 321 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(l ,2,4- triazolo)methyl-moφholine; 322 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(2- oxo- 1 ,3 -imidazolo)methy 1-moφholine; 323 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo- 1 ,2,4-triazolo)methyl-moφholine; 324 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(l ,2,4- triazolo)methyl-moφholine; 325 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(2- oxo- 1 ,3-imidazolo)methyl-moφholine; 326 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 327 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-( 1 ,2,4-triazolo)methyl-moφholine; 328 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(2-oxo-l,3-imidazolo)methyl-moφholine; 329 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo-l,2,4-triazolo)methyl-moφholine; 330 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-( 1 ,2,4- triazolo)methyl-moφholine; 331 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(2- oxo- 1 ,3-imidazolo)methyl-moφholine; 332 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 332) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl-moφholine; 333) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(2-oxo-l,3-imidazolo)methyl-moφholine; 334) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 335) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl-moφholine; 336) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(3-(2-oxo-l ,3-imidazolo)methyl-moφholine; 337) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 338) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 339) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(3 -(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 340) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 341) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl -moφholine; 342) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(3-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 343) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 344) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 345) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(3-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 346) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-4-(3-(5-oxo-l,2,4-triazolo)methyl- moφholine; 347) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 348) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-4-(3-(2-oxo- 1 ,3-imidazolo)methyl- moφholine; 349) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(3-(5-oxo-l,2,4-triazolo)methyl-moφholine; 350) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(3-(l,2,4-triazolo)methyl-moφholine; 351) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 352) 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(3-(-l,2,4-triazolo)methyl-moφholine; 353) 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 354) 2-(R)-(l -(R)-(3-(chloro)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(3-(-l,2,4-triazolo)methyl -moφholine; 355) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 356) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(- 1 ,2,4-triazolo)methyl-moφholine; 357) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (2-oxo- l,3-imidazolo)methyl -moφholine; 358) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(-l,2,4-triazolo)methyl-moφholine; 359) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 360) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(-l,2,4-triazolo)methyl-moφholine; 361) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(2-oxo-l,3-imidazolo)methyl -moφholine; 362) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(- 1 ,2,4-triazolo)methyl-moφholine; 363) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 364) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(- 1 ,2,4-triazolo)methyl-moφholine; 365) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (2-oxo- 1 ,3-imidazolo)methyl-moφholine; 366) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(-l ,2,4-triazolo)methyl-moφholine; 367) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 368) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(- 1 ,2,4-triazolo)methyl-moφholine; 369) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 370) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(-l,2,4-triazolo)methyl-moφholine; 371) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(2-oxo-l ,3-imidazolo)methyl-moφholine; 372) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(-l,2,4-triazolo)methyl-moφholine; 373) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 374) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(-l,2,4-triazolo)methyl-moφholine; 375) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 376) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(-l,2,4-triazolo)methyl-moφholine; 377) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 378) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(-l,2,4-triazolo)methyl-moφholine; 379) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 380) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(-l,2,4-triazolo)methyl-moφholine; 381 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-ρhenyl-4-(3-(2-oxo-l,3-imidazolo)methyl-moφholine; 382 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-ρhenyl-4-(3-(- 1 ,2,4-triazolo)methyl -moφholine; 383 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(2-oxo-l ,3-imidazolo)methyl-moφholine; 384 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(- 1 ,2,4-triazolo)methyl-moφholine; 385 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(2- oxo- 1 ,3-imidazolo)methy 1-moφholine; 386 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(- 1 ,2,4-triazolo)methyl-moφholine; 387 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(2- oxo-l,3-imidazolo)methyl-moφholine; 388 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-phenyl-4-(3-(-l,2,4- triazolo)methyl-moφholine; 389 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-phenyl-4-(3-(2-oxo-l ,3- imidazolo)methyl-moφholine; 390 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (- 1 ,2,4-triazolo)methyl-moφholine; 391 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (2-oxo- 1 ,3-imidazolo)methyl-moφholine; 392 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (- 1 ,2,4-triazolo)methy 1-moφholine; 393 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (2-oxo- 1 ,3-imidazolo)methyl-moφholine; 394 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (- 1 ,2,4-triazolo)methy 1-moφholine; 395 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (2-oxo- 1 ,3-imidazolo)methyl-moφholine; 396 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (-1 ,2,4-triazolo)methyl-moφholine; and 397 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (2-oxo-l , 3-imidazolo)methyl-moφholine. EXAMPLE 88 2-(R)-(2,5-Bis(trifluoromethyl)benzoyloxy)-3-(S)-(4-fluorophenyl)-4- benzyl-moφholine The title compound was prepared from 3-(S)-(4- fluorophenyl)-4-benzyl-2-moφholinone (from Example 59) using a procedure analogous to Example 67. Mass Spectrum (Cl): m/Z 528 (M+H) lH NMR (CDC13, 360 MHz, ppm): δ 2.46 (dt, IH), 2.90 (dd, 2H), 3.76 (dd, J= 11.6, 2.0, IH), 3.88 (d, J= 13.6, IH), 4.18 (t, IH), 6.20 (d, J=2.8, IH), 7.04 (d, J= 8.4, 2H), 7.24-7.32 (m, 5H), 7.50, (m, 2H), 7.60 (s, IH), 7.88 (dd, 2H). EXAMPLE 89 2-(R)-( 1 -(2,5-Bis(trifluoromethyl)phenyl)ethenyloxy)-3-(S)-(4- fluorophenyl)-4-benzyl-moφholine The title compound was prepared from 2-(R)-(2,5- bis(trifluoromethyl) benzoyloxy)-3-(S)-(4-fluorophenyl)-4-benzyl- moφholine (from Example 88) using a procedure analogous to Example 68. H NMR (CDCI3, 250 MHz, ppm): δ 2.30 (dt, J= 3.5, 11.9, IH), 2.74 (app d, J= 9.4, IH), 2.82 (d, J=13.5, IH), 3.55-3.60 (m, 2H), 3.72 (d, J= 13.5, IH), 4.10 (dt, J= 2.4, 11.7, IH), 4.22 (d, J= 2.7, IH), 4.67 (d, J=2.8, IH), 5.18 (d, J=2.8, IH), 6.90 (t, J=8.7, 2H), 7.08 (s, IH), 7.13- 7.23 (m, 5H), 7.36 (dd, J= 5.6, 8.7, 2H). 7.62 (d, J= 8.4, IH), 7.72 (d, J= 8.4. IH). EXAMPLE 90 2-(R)-(l-(R)-(2,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenvD-moφholine The title compound was prepared from 2-(R)-(l-(2,5- bis(trifluoromethyl) phenyl)ethenyloxy)-3-(S)-(4-fluorophenyl)-4- benzyl-moφholine (from Example 89) using a procedure analogous to Example 74. Mass Spectrum (Cl): m/Z 438 (M+H) lH NMR Spectrum (HCl salt, d6-DMSO, 360 MHz, ppm): δ 1.47 (d, J= 8.7, 3H), 3.88 (d, J= 11.8, IH), 4.20 (dt, J= 3.7, 11.8, IH), 4.50 (s, IH), 4.58 (s, IH), 5.17 (m, IH), 7.04 (s, IH), 7.23 (t, J= 8.8, 2H), 7.55 (m, 2H), 7.77 (d, J= 8.1, IH), 7.88 (d, J= 8.3, IH), 10.1 (br s, IH). EXAMPLE 91 2-(R)-(l-(R)-(2,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(3-(5-oxo-1.2.4-triazolo)methyl-moφholine The title compound was prepared from 2-(R)-(l-(R)-(2,5- bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)-moφholine (from Example 90) using a procedure analogous to Example 70, mp 162-168 °C. lH NMR (d6-DMSO, 360 MHz, ppm) δ 1.37 (d, J= 6.4, 3H), 2.40 (dt, J= 3.3, 11.9, IH), 2.77 (d, J= 14.0, IH), 2.86 (d, J= 11.5, IH), 3.37 (d, J= 14.4, IH), 3.48 ( d, J= 2.7, IH), 3.64 (d, J= 11.0, IH), 4.11 (t, J= 9.8, IH), 4.18 ( d, J= 2.8, IH), 5.16 (q, J= 6.2, IH), 6.90 (s, IH), 7.08 ( t, J= 8.8, 2H), 7.50 (br t, IH), 7.74 (d, J= 8.3, IH), 7.85 (d, J= 8.3, IH), 11.25 s, IH), 11.35 (s, IH). EXAMPLE 92 2-(R)-(l-(R)-(2,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(3-(1.2.4-triazolo)methyl)moφholine The title compound was prepared from 2-(R)-(l-(R)-(2,5- bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)-moφholine (from Example 90) using a procedure analogous to Example 17, mp 98- 100 °C. Mass Spectrum (Cl): m/Z 519 (M+H) lH NMR (d6-DMSO, 360 MHz, ppm): δ 1.36 (d, J= 6.4, 3H), 2.46 (dt, J= 3.26, 11.9, IH), 2.89 (d, J= 11.0, IH), 3.16 (d, J= 13.9, IH), 3.57- 3.64 (m, 3H), 4.09 (t, J= 10.5, IH), 4.18 (d, J= 2.6, IH), 5.14 (q, J= 6.4, IH), 6.90 (s, IH), 7.11 (t, J= 8.7, 2H), 7.48 (m, 2H), 7.72 ( d, J= 8.3, IH), 7.83 (d, J= 8.3, IH), 8.36 (br s), 13.8 (s, IH). EXAMPLE 93 2-(R)-(l-(R)-(2,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(4-(2-oxo-1.3-imidazolo)methyl)moφholine The title compound was prepared from 2-(R)-(l-(R)-(2,5- bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)-moφholine (from Example 90) using a procedure analogous to Example 83. A sample was recrystallized from aqueous ethanol, mp 203-205 °C. lH NMR (d6-DMSO, 360 MHz, ppm): δ 1.35 (d, J= 6.4, 3H), 2.25 (dt, J= 3.1, 11.8, IH), 2.58 (d, J= 13.9, IH), 2.88 (d, J= 11.6, IH), 3.24 (d, J= 14.0, IH), 3.35 (d, J= 2.7, IH), 3.64 (dd, J= 9.6, IH), 4.09 (t, J= 9.8, IH), 4.16 (d, J= 2.7, IH), 5.14 (q, J= 6.5, IH), 5.97 (s, IH), 6.89 (s, IH), 7.07 (t, J= 8.7, IH), 7.49 (m, IH), 7.72 (d, J= 8.1, IH), 7.83 (d, J= 8.3, IH), 9.57 (s, IH), 9.80 (s, IH). EXAMPLE 94 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 H.4H- 1.2.4-triazolo)methyl)moφholine N-oxide A solution of 125 mg (0.25 mmol) of 2-(S)-(3,5- bis(trifluoromethyl) benzyloxy)-3-(S)-phenyl-4-(3-(5-oxo-lH,4H-l,2,4- triazolo)methylmoφholine in 10 mL of methylene chloride was treated with 100 mg of 80-85% 3-chloroperoxybenzoic acid and the resulting mixture was stirred at room temperature for 1 hour. The reaction mixture was concentrated in vacuo and the residue was partitioned between 25 mL of ethyl acetate and 25 mL of saturated aqueous sodium bicarbonate solution. The organic layer was separated, washed with 15 mL of 0.1 N aqueous sodium hydroxide solution, dried over sodium sulfate and concentrated in vacuo to afford 142 mg of crude product. Flash chromatography on silica gel (15 mL column) using 95:5:0.5 v/v/v methylene chloride/methanol/water as the eluant afford 83 mg (64%) of the title compound. Mass Spectrum (NH3-CI): m/Z 519 (20%, M+), 406 (90%), 404 (100%). lH NMR (CDCI3, 500 MHz, ppm): δ 3.56-3.66 (m, IH), 3.80 (br d, J= 10.0, IH), 3.95-4.20 (m, 3H), 4.43-4.47 (m, IH), 4.50 (d, J=13.4, IH), 4.86-4.94 (m, 3H), 7.32 (app s, 5H), 7.56 (s, 2H), 7.68 (s, IH), 8.40 (br s, IH) 12.15 (br s, IH). EXAMPLE 95 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-4-(3-(4- (ethoxycarbonyloxy- 1 -eιhyl)5-oxo- 1 H,- 1 ,2,4-triazolo)methyl)- moφholine A mixture of 250 mg (0.5 mmol) of 2-(S)-(3,5- bis(trifluoromethyl) benzyloxy)-3-(S)-phenyl-4-(3-(5-oxo-lH,4H-l ,2,4- triazolo)methylmoφholine, 70 mg (0.5 mmol) of N,N-diisopropylethyl- amine and 100 mg (l-chloroethyl)ethylcarbonate in 15 mL of dichloroethane was heated at reflux for 16 hours. TLC analysis of the reaction mixture indicated incomplete reaction; the dichloroethane solvent was replaced with toluene, 70 mg of N,N-diisopropylethy lamine and 100 mg (l-chloroethyl)ethylcarbonate were added to the reaction and the resulting mixture was heated at reflux for 24 hours. At this time, an additional 70 mg of N,N-diisopropylethy lamine and 100 mg (1 - chloroethyl) ethylcarbonate were introduced into the reaction and the resulting mixture was heated at reflux for 24 hours. The reaction was cooled to room temperature and partitioned between 25 mL of ethyl acetate and 25 mL of saturated aqueous sodium bicarbonate solution and the layers were separated. The aqueous layer was extracted with ethyl acetate. The organic layers were combined, dried over sodium sulfate and concentrated in vacuo to afford 420 mg of crude product as a foam. Flash chromatography on silica gel (25 mL column) using 100:1 v/v, then 50:1 v/v methylene chloride/isopropanol as the eluant afforded 68 mg (22%) of the title compound. Mass Spectrum (ESI): m/Z 619 (15%, M+l), 575 (100%). lH NMR (CDCI3, 500 MHz, ppm): δ 1.38 (t, J= 7.0, 3H), 2.61 (dt, J= 3.0, 12.0, IH), 2.90 (d, J= 11.5, IH), 3.03 (d, J= 15.5, IH), 3.63 (d, J= 2.0, IH), 3.66-3.71 (m, 2H), 4.20 (dt, J= 2.0, 11.5, IH), 4.41-4.45 (m, 2H), 4.48 (d, J= 13.5, IH), 4.71 (d, J= 2.0, IH), 4.81 (d, J= 13.5, IH), 7.34-7.48 (m, 5H), 7.47 (s, 2H), 7.72 (s, IH), 10.1 (br s, IH). 1 c NMR (CDCI3, 125 MHz, ppm): δ 14.2, 25.2, 50.7, 52.6, 59.2, 64.1, 64.5, 67.7, 69.7, 97.9, 121.5, 123.1 (q, J= 271), 127.2, 128.7, 129.1, 131.5 (q, J= 32.9), 136.0, 140.0, 146.8, 148.4, 152.3, 163.1. EXAMPLE 96 2-(R)-(l-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)- phenyl-4-(3-(4-monophosphoryl-5-oxo-lH-l ,2,4-triazolo)methyl)- moφholine, dipotassium salt; or 2-(R)-(l-(R)-(3,5-Bis(trifluoro- methyl)phenyl)ethoxy)-3-(S)-(4-fluoro)-phenyl-4-(3-(l-mono- phosphoryl-5-oxo-lH-l ,2,4-triazolo)methyl)moφholine, dipotassium salt; or 2-(R)-(l-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)-phenyl-4-(3-(2-monoρhosphoryl-5-oxo- 1 H- 1 ,2,4-triazolo)- methyl)moφholine, dipotassium salt; or 2-(R)-(l-(R)-(3,5- Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)-phenyl-4-(3-(5- oxyphosphoryl-lH-1.2.4-triazolo)methyl)moφholine. dipotassium salt A solution of 450 mg (0.84 mmol) of 2-(R)-(l -(R)-(3,5- bis(trifluoro-methyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5- oxo-lH,, 4H-l,2,4-triazolo) methylmoφholine in 20 mL of THF at 0 °C was treated with 0.84 mL of 1.0 M n-butyllithium solution in hexanes. The resulting solution was stirred cold for 5 minutes and was treated with 630 mg (1.17 mmol) of tetrabenzylpyrophosphate in one portion as a solid. The cooling bath was removed and the reaction was stirred at room temperature for 45 minutes. The reaction was quenched with 25 mL of saturated aqueous sodium bicarbonate solution and was extracted with 50 mL of ethyl ether. The organic layer was separated, washed with 25 mL of saturated aqueous sodium bicarbonate solution, 25 mL of 0.5 N aqueous potassium hydrogen sulfate solution, 25 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated in vacuo. The crude dibenzyl ester was dissolved in 25 mL of methanol. A solution of 168 mg (1.68 mmol) of potassium bicarbonate was added to the ester solution and the resulting mixture was hydrogenated at 40 psi in the presence of 45 mg of 10% palladium on carbon catalyst for 75 minutes. The catalyst was filtered onto a pad of Celite; the reaction flask and filter cake were rinsed well with methanol (~200 mL), the filtrate was concentrated in vacuo and dried. The residue was partially dissolved in methanol and filtered; the filtrate was concentrated and dried. The resulting solid was recrystallized from isopropanol to afford 280 mg of crude title compound. The solid was partitioned between 40 mL of ethyl ether and 20 mL of water; mixing of the layers resulted in an emulsion. Centrifugation at 2800 φm for 15 minutes broke the emulsion; the aqueous layer was separated and lyophilized to afford 188 mg (33%) of the compound tentatively identified as 2-(R)-(l -(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)-phenyl-4-(3-(4-monophosphoryl-5-oxo-lH-l,2,4- triazolo)methyl)-moφholine, dipotassium salt as a solid. lH NMR (CD3OD, 500 MHz, ppm): δ 1.43 (d, J= 6.5, 3H), 2.45 (app t, J= 8.5, IH), 2.80 (d, J= 14.0, IH), 2.92 (d, J= 11.5, IH), 3.47-3.66 (m, 4H), 4.25 (app t, J= 11.5, IH), 4.36 (d, J= 1.5, IH), 4.94 (q, J= 6.6, IH), 7.05 (t, J= 8.5, 2H), 7.3 l(s, 2H), 7.52 (br s, 2H), 7.71 (s, IH). 13C NMR (CD3OD, 125 MHz, ppm): δ 24.7, 52.3, 53.4, 60.5, 70.6, 73.7, 97.2, 116.1 (d, J= 21.9), 122.3, 124.6 (q, J= 271.0), 127.7, 132,3, 132.6, 132.8, 134.3, 145.2 (d, J=11.0), 147.5, 159.0 (d, J= 10.1), 164.0 (d, J=244.4). EXAMPLE 97 2-(S)-(l-(R)-(3,5-Bis(trifluoromethyl)-phenyl)ethoxy)-3-(S)-(4- fluoro) phenyl-4-(3-(l-phosphoryl-5-oxo-4H-l,2,4-triazolo)methylmoφholine, bis(N-methyl-D-glucamine) salt Tetrabenzylpyrophosphate was prepared in 71% yield using the procedure described by Khorana and Todd (J. Chem. Soc.2257 (1953)). A solution of 2.00 g (3.7 mmol) of 2-(S)-(l-(R)-(3,5- bis(trifluormethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(lH,4H- 5-oxo-l,2,4-triazolo)methylmoφholine and 2.80 g (5.2 mmol) of tetrabenzylpyrophosphate in 50 mL of dry tetrahydrofuran was cooled to 0 °C. A 1.0 M solution of sodium bis(trimethylsilyl)-amide ("NaHMDS", 9.4 mL, 9.4 mmol) was added to the cooled reaction mixture using a syringe pump at a rate of 1 equivalent/hour maintaining the internal temperamre at 0 °C. After the addition of the NaHMDS, the reaction was stirred at 0 °C for 15 minutes and quenched with 100 mL of saturated aqueous sodium bicarbonate solution. The quenched mixture was extracted with 300 mL of ethyl ether; the ether extract was washed with 100 mL of 0.5 N aqueous potassium bisulfate solution, 100 mL of saturated aqueous sodium bicarbonate solution, 100 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated in vacuo. A solution of the crude dibenzyl ester in 50 mL of methanol, a solution of 1.45 g (7.4 mmol) of N-methyl-D-glucamine in 10 mL of water and 200 mg of 10% palladium on carbon catalyst were combined and the mixture was hydrogenated at 40 psi for 2 hours. The reaction mixnire was filtered through a pad of Celite; the reaction flask and filter cake were rinsed well with methanol (400 mL). The filtrate was concentrated in vacuo. The crude product was redissolved in 25 mL of methanol; 125 mL of isopropanol was added to the solution and the resulting mixture was aged at room temperture for 30 minutes. The solid that had precipitated was filtered, washed with 75 mL of isopropanol, 75 mL of ethyl ether and air dried. The solid was partitioned between 150 mL of ethyl ether and 150 mL of water; an emulsion formed on mixing of the layers. The emulsion was transferred into 50 mL centrifuge tubes; centrifugation at 3000 φm for 15 minutes caused separation of the layers. The organic layers were drawn off and the aqueous layers were combined, filtered and the filtrate lyophilized to afford 3.40 g of 2-(S)-(l-(R)-(3,5-bis(trifluoro- methyl)phenyl)-ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(l-phosphoryl-5- oxo-4H-l ,2,4-triazolo)methylmoφholine, bis(N-methyl-D-glucamine) salt as an amoφhous solid. Its purity was determined to be > 99% by HPLC. lH NMR (CD3OD, 500 MHz, ppm): δ 1.43 (d, J= 6.6, 3H), 2.46 (app t, J= 11.2, IH), 2.72 (s, 6H), 2.84 (d, J= 13.9, IH), 2.94 (d, J= 10.3, IH), 3.12-3.30 (m, 4H), 3.42-3.83 (m, 14H), 4.19-4.25 (m, 3H), 4.35 (d, J= 2.2, IH), 7.04 (t, J= 8.5, 2H), 7.30 (s, 2H), 7.52 (br s, 2H), 7.70 (s, IH). 13c NMR (CD3OD, 125 MHz, ppm): δ 24.7, 34.4, 52.3, 53.1, 53.5, 60.5, 64.7, 69.9, 70.4, 72.0, 72.4, 72.6, 73.6, 97.1 , 116.2 (d, J= 21.9), 122.3, 124.5 (q, J= 271.0), 127.7, 132.3, 132.7 (q, J= 33.8), 134.2, 145.9, 147.5, 158.9, 163.9 (d, J= 245.3). EXAMPLE 98 Typical Pharmaceutical Compositions Containing a Compound of the Invention A: Dry Filled Capsules Containing 5 mg of Active Ingredient Per Capsule Ingredient Amount per capsule (mg) Active ingredient 5 Lactose 194 Magnesium stearate Capsule (size No. 1) 200 The active ingredient may be reduced to a No. 60 powder and the lactose and magnesium stearate may then be passed through a No. 60 blotting cloth onto the powder. The combined ingredients may then be mixed for about 10 minutes and filled into a No. 1 dry gelatin capsule. B: Tablet A typical tablet would contain the active ingredient (25 mg), pregelatinized starch USP (82 mg), microcrystalline cellulose (82 mg) and magnesium stearate (1 mg). C: Suppository Typical suppository formulations for rectal administration contain the active ingredient (0.08-1.0 mg), disodium calcium edetate (0.25-0.5 mg), and polyethylene glycol (775-1600 mg). Other suppository formulations may be made by substituting, for example, butylated hydroxytoluene (0.04-0.08 mg) for the disodium calcium edetate and a hydrogenated vegetable oil (675-1400 mg) such as Suppocire L, Wecobee FS, Wecobee M, Witepsols, and the like, for the polyethylene glycol. D: Injection A typical injectible formulation contains the active ingredient, sodium phosphate dibasic anhydrous (11.4 mg), benzyl alcohol (0.01 ml) and water for injection (1.0 ml). While the invention has been described and illustrated with reference to certain particular embodiments thereof, those skilled in the art will appreciate that various adaptations, changes, modifications, substitutions, deletions, or additions of procedures and protocols may be made without departing from the spirit and scope of the invention. For example, effective dosages other than the particular dosages as set forth herein above may be applicable as a consequence of variations in the responsiveness of the mammal being treated for any of the indications with the compounds of the invention indicated above. Likewise, the specific pharmacological responses observed may vary according to and depending upon the particular active compounds selected or whether there are present pharmaceutical carriers, as well as the type of formulation and mode of administration employed, and such expected variations or differences in the results are contemplated in accordance with the objects and practices of the present invention. It is intended, therefore, that the invention be defined by the scope of the claims which follow and that such claims be inteφreted as broadly as is reasonable.

Claims: WHAT IS CLAIMED IS: 1. A compound of structural formula: or a pharmaceutically acceptable salt thereof, wherein: R2 and R3 are independently selected from the group consisting of: (1) hydrogen, (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR9R 10, wherein R9 and R 10 are independently selected from: (i) hydrogen, (ii) Cl-6 alkyl, (iii) hydroxy-Ci-6 alkyl, and (iv) phenyl, (i) -NR9COR 10, wherein R9 and R 1 are as defined above, (j) -NR9C02Rl°, wherein R9 and RlO are as defined above, (k) -CONR9R10, wherein R9 and RlO are as defined above, (1) -COR9, wherein R9 is as defined above, and (m) -C02R9, wherein R9 is as defined above; (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Ci-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR9R 10 wherein R9 and R 10 are as defined above, (i) -COR9 wherein R9 is as defined above, (j) -C02R9, wherein R9 is as defined above; (4) C2-6 alkynyl; (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) Cl-6 alkoxy, (c) Cl-6 alkyl, (d) C2-5 alkenyl, (e) halo, (f) -CN, (g) -N02, (h) -CF3, (i) -(CH2)m-NR9RlO, wherein m, R and RlO are as defined above, (j) -NR9COR10, wherein R9 and RlO are as defined above, (k) -NR9C02R 1 °, wherein R9 and R 10 are as defined above, (1) -CONR9R10, wherein R9 and RlO are as defined above, (m) -C02NR9R 10, wherein R9 and R 10 are as defined above, (n) -COR9, wherein R9 is as defined above; (o) -C02R9, wherein R9 is as defined above; and, alternatively, the groups R2 and R3 are joined together to form a carbocyclic ring selected from the group consisting of: (a) cyclopentyl, (b) cyclohexyl, (c) phenyl, and wherein the carbocyclic ring is unsubstituted or substituted with one or more substituents selected from: (i) Cl-6alkyl, (ii) Cl-6alkoxy, (iii) -NR9R10, wherein R9 and RlO are as defined above, (iv) halo, and v) trifluoromethyl; and, alternatively, the groups R2 and R3 are joined together to form a heterocyclic ring selected from the group consisting of: (a) pyrrolidinyl, (b) piperidinyl, (c) pyrrolyl, (d) pyridinyl, (e) imidazolyl, (f) furanyl, (g) oxazolyl, (h) thienyl, and (i) thiazolyl, and wherein the heterocyclic ring is unsubstituted or substituted with one or more substituent(s) selected from: (i) Cl-6alkyl, (ii) oxo, (iii) Cl-6alkoxy, (iv) -NR9R10, wherein R9 and RlO are as defined above, (v) halo, and (vi) trifluoromethyl; R6, R7 and R8 are independently selected from the group consisting of: (1) hydrogen; (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR9R 10, wherein R9 and R 10 are as defined above, (i) -NR9C0R 10, wherein R9 and R 10 are as defined above, (j ) -NR9C02R 0, wherein R9 and R 10 are as defined above, (k) -CONR9R10, wherein R9 and RlO are as defined above, (1) -COR9, wherein R9 is as defined above, and (m) -C02R9, wherein R9 is as defined above; (n) -COR9, wherein R9 is as defined above; (o) -C02R9, wherein R9 is as defined above; (6) halo, (7) -CN, (8) -CF3, (9) -N02,- (10 -SR14, wherein Rl4 is hydrogen or Cl-5alkyl, (11 -SOR14, wherein Rl4 is as defined above, (12 -Sθ2Rl4, wherein Rl4 is as defined above, (13 NR9COR10, wherein R9 and RlO are as defined above, (14 CONR9COR10, wherein R9 and RlO are as defined above, (15 NR9R10, wherein R9 and RlO are as defined above, (16 NR9CO2R 0, wherein R9 and RlO are as defined above, (17 hydroxy, (18 Cl-6alkoxy, (19 COR9, wherein R9 is as defined above, (20 C02R9, wherein R9 is as defined above, (21 2-pyridyl, (22 3-pyridyl, (23 4-pyridyl, (24 5-tetrazolyl, (25 2-oxazolyl, and (26 2-thiazolyl; Rl i, Rl2 and Rl3 are independently selected from the definitions of R6, R7 and R8, or -OX; A is selected from the group consisting of: (1) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Ci-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, wherein halo is fluoro, chloro, bromo or iodo, (h) -NR9R10, wherein R9 and RlO are as defined above, (i) -NR9COR 10, wherein R9 and R 10 are as defined above, (j ) -NR9C02R 10, wherein R9 and R 10 are as defined above, (k) -CONR9R 10, wherein R9 and R 10 are as defined above, (1) -COR9, wherein R9 is as defined above, and (m) -C02R9, wherein R9 is as defined above; (2) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR9R 10 wherein R9 and R 10 are as defined above, (i) -COR9 wherein R9 is as defined above, and (j) -C02R9, wherein R9 is as defined above; and (3) C2-6 alkynyl; B is a heterocycle, wherein the heterocycle is selected from the group consisting of: X and wherein the heterocycle is substituted in addition to -X with one or more substituent(s) selected from: (i) hydrogen; (ii) Cl-6 alkyl, unsubstituted or substituted with halo, -CF3, -OCH3, or phenyl, (iii) Cl -6 alkoxy, (iv) oxo, (v) hydroxy, (vi) thioxo, (vii) -SR9, wherein R9 is as defined above, (viii) halo, (ix) cyano, (x) phenyl, (xi) trifluoromethyl, (xii) -(CH2)m-NR9RlO, wherein m is 0, 1 or 2, and R9 and RlO are as defined above, (xiii) -NR9COR10, wherein R9 and RlO are as defined above, (xiv) -CONR9R10, wherein R9 and RlO are as defined above, (xv) -C02R9, wherein R9 is as defined above, and (xvi) -(CH2)m-OR9, wherein m and R9 are as defined above; p is 0 or 1; X is selected from: (a) -PO(OH)0 _ • M+, wherein M+ is a pharmaceutically acceptable monovalent counterion, (b) -PO(0->2 • 2M+, (c) -PO(0")2 • D2+, wherein D2+ is a pharmaceutically acceptable divalent counterion, (d) -CH(R4)-PO(OH)0- • M+, wherein R4 is hydrogen or C1-3 alkyl, (e) -CH(R4)-PO(0-)2 • 2M+, (f) -CH(R4)-PO(0-)2 • D2+ (i) -CO-CH2CH2-CO2- • M+, (j) -CH(CH3)-0-CO-R5, wherein R5 is selected from the group consisting of: ( ϋi ) A O C0 9 " M + (k) hydrogen, with the proviso that if p is 0 and none of Rl 1 , Rl2 or Rl3 are -OX, then X is other than hydrogen; Y is selected from the group consisting of: (1) a single bond, (2) -0-, (3) -S-, (4) -CO-, • (5) -CH2-, (6) -CHR15-, and (7) -CR 15R 16- , wherein R 15 and R 16 are independently selected from the group consisting of: (a) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (i) hydroxy, (ii) oxo, (iii) Cl-6 alkoxy, (iv) phenyl-Cl-3 alkoxy, (v) phenyl, (vi) -CN, (vii) halo, (viii) -NR9R10, wherein R9 and RlO are as defined above, (ix) -NR9C0R 10, wherein R9 and R 10 are as defined above, (x) -NR9C02R 10, wherein R and R 10 are as defined above, (xi) -C0NR9R 10, wherein R9 and R 10 are as defined above, (xii) -COR9, wherein R9 is as defined above, and (xiii) -C02R , wherein R9 is as defined above; (b) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (i) hydroxy, (ii) Cl-6 alkoxy, (iii) Cl-6 alkyl, (iv) C2-5 alkenyl, (v) halo, (vi) -CN, (vii) -Nθ2, (viii) -CF3, (ix) -(CH2)m-NR9R 10, wherein m, R9 and R 10 are as defined above, (x) -NR9COR 10, wherein R9 and R 10 are as defined above, (xi) -NR9C02R 1 °, wherein R9 and R 10 are as defined above, (xii) -CONR9R 10, wherein R9 and R 10 are as defined above, (xiii) -CO2NR9R10, wherein R9 and RlO are as defined above, (xiv) -COR9, wherein R9 is as defined above, and (xv) -C02R9, wherein R9 is as defined above; Z is selected from: (1) hydrogen, (2) Cl-6 alkyl, and (3) hydroxy, with the proviso that if Y is -0-, Z is other than hydroxy, or if Y is -CHR15-, then Z and Rl are optionally joined together to form a double bond. 2. The compound of Claim 1 wherein: R2 and R3 are independently selected from the group consisting of: (1) hydrogen, (2) Cl-6 alkyl, (3) C2-6 alkenyl, and (4) phenyl; Rl 1, Rl2 and Rl3 are independently selected from the group consisting of: (1) fluoro, (2) chloro, (3) bromo, and (4) iodo; A is unsubstituted Cl-6 alkyl; B is selected from the group consisting of: H . N-N N-N H X p is 0; X is selected from: (a) -PO(OH)0" • M + , wherein M + is a pharmaceutically acceptable monovalent counterion, (b) -PO(0 " )2 • 2M+, (c) -PO(0")2 • 2+, wherein D + is a pharmaceutically acceptable divalent counterion, (d) -CH(R 4 )-PO(OH)0- • M+, wherein R4 is hydrogen or methyl, (e) -CH(R 4 )-PO(0-)2 • 2M+, wherein R 4 is hydrogen or methyl, (f) -CH(R 4 )-PO(0-)2 • D2+, wherein R is hydrogen or methyl, (i) -CO-CH2CH2-CO2- • M+, (j) -CH(CH3)-0-CO-R5, wherein R is selected from t he group consisting of: (i) A • NH 3 + M O ' Y is -0-; Z is hydrogen or Ci-4 alkyl. 3. The compound of Claim 1 wherein Z is Cl-4 alkyl. 4. The compound of Claim 1 wherein Z is -CH3. 5. The compound of Claim 1 wherein A is -CH2- or -CH(CH3)- 6. The compound of Claim 1 wherein -B is selected from the group consisting of: X 10 25 30 7. The compound of Claim 1 wherein -A-B is selected from the group consisting of: 8. The compound of Claim 1 wherein -A-B is selected from the group consisting of: 9. The compound of Claim 1 wherein X is selected from the group consisting of: (a) -P0(0")2 • 2M + , wherein M + is a pharmaceutically acceptable monovalent counterion, (b) -PO(0")2 • D2+, wherein D2+ is a pharmaceutically acceptable divalent counterion, (c) -CH(CH3)-0-CO-CH2CH2-NH3+- M", and (d) -CH(CH3)-0-CO-CH2CH2-NH2+-(CH2CH2-OH) • M-. 10. The compound of Claim 1 of the structural formula II: II or a pharmaceutically acceptable salt thereof, wherein R2, R3, R6, R7, R8, Rl l, Rl2, Rl3, A, B and Z are as defined in Claim 1. 11. The compound of Claim 1 of the structural formula III: or a pharmaceutically acceptable salt thereof, wherein R2, R3, R6, R7, R8, Rl l , R12, Rl3,A, B, and Z are as defined in Claim 1. 12. A compound which is selected from the group consisting of: (1) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-4-(3-(5- oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)moφholine N-oxide; (2) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-4-(3-(4- (ethoxycarbonyloxy- 1 -ethyl)5-oxo- 1 H- 1 ,2,4-triazolo)- methyl)moφholine; (3) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)-phenyl-4-(3-(4-monophosphoryl-5-oxo-lH-l,2,4- triazolo)methyl)moφholine; (4) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)-ρhenyl-4-(3-(l-monophosphoryl-5-oxo-lH-l ,2,4- triazolo)methyl)moφholine; (5) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)-phenyl-4-(3-(2-monophosphoryl-5-oxo-lH- 1,2,4- triazolo)methyl)moφholine; (6) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)-phenyl-4-(3-(5-oxyphosphoryl-lH-l ,2,4-triazolo)- methyl)moφholine; (7) 2-(S)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)-phenyl-4-(3-(l -phosphoryl-5-oxo-4H-l ,2,4- triazolo)methyl)moφholine; or a pharmaceutically acceptable salt thereof. 13. The compound of Claim 12 wherein the pharmaceutically acceptable salt is the bis(N-methyl-D-glucamine) salt. 14. A compound which is selected from the group consisting of: 15 30 wherein K+ is a pharmaceutically acceptable counterion. 15. A compound which is characterized by the following spectral data: lH NMR (CD3OD, 500 MHz, ppm): δ 1.43 (d, J= 6.5 Hz, 3H), 2.45 (app t, J= 8.5 Hz, IH), 2.80 (d, J= 14.0 Hz, IH), 2.92 (d, J= 11.5 Hz, IH), 3.47-3.66 (m, 4H), 4.25 (app t, J= 11.5 Hz, IH), 4.36 (d, J= 1.5 Hz, IH), 4.94 (q, J= 6.6 Hz, IH), 7.05 (t, J= 8.5 Hz, 2H), 7.31(s, 2H), 7.52 (br s, 2H), 7.71 (s, IH); 13c NMR (CD3OD, 125 MHz, ppm): δ 24.7, 52.3, 53.4, 60.5, 70.6, 73.7, 97.2, 116.1 (d, J= 21.9 Hz), 122.3, 124.6 (q, J= 271.0 Hz), 127.7, 132,3, 132.6, 132.8, 134.3, 145.2 (d, J=11.0 Hz), 147.5, 159.0 (d, J= 10.1 Hz), 164.0 (d, J=244.4 Hz). 16. A prodrug of a parent compound, wherein the parent compound is selected from the group consisting of: 1 ) (+/-)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3-phenyl- moφholine; 2) (2R,S)-(3 ,5-bis(trifluoromethyl)benzy loxy)-(3R)-pheny 1-(6R)- methyl-moφholine; 3) (2R,S)-(3,5-bis(trifluoromethyl)benzyloxy)-(3S)-phenyl-(6R)- methyl-moφholine ; 4) (+/-)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3-phenyl-4- methylcarboxamido-moφholine; 5) (+/-)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3-phenyl-4-methoxy- carbonylmethyl-moφholine; 6) 2-(2-(3,5-bis(trifluoromethyl)phenyl)ethenyl)-3-phenyl-5-oxo- moφholine; 7) 3-phenyl-2-(2-(3,5-bis(trifluoromethyl)phenyl)-ethyl)- moφholine; 8) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(S)- methyl-moφholine; 9) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(S)- methyl-moφholine; 10) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(S)- methyl-moφholine; 11) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(S)- methyl-moφholine; 12) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(R)- methyl-moφholine; 13) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)- methyl-moφholine; 14) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(R)- methyl-moφholine; 15) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)- methyl-moφholine; 16) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl- moφholine; 17) 4-(3-(l,2,4-triazolo)methyl)-2-(S)-(3,5-bis(trifluoro- methyl)benzyloxy)-3-(S)-phenyl-moφholine; 18) 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-2-(S)-(3,5-bis- (trifluoromethyl)benzyloxy)-3-(S)-phenyl-moφholine; 19) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(R)- methyl-moφholine; 20) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(R)- methyl-moφholine; 21) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(R)- methyl-moφholine; 22) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(R)- methyl-moφholine; 23) 2-(R)-(3,5-bis(trifluoromethyl)-benzyloxy)-3-(S)-phenyl-5-(S)- methyl-moφholine; 24) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(S)- methyl-moφholine; 25) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)- methyl-moφholine; 26) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)- phenyl-moφholine; 27) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)- phenyl-moφholine; 28) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)- phenyl-moφholine; 29) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)- phenyl-moφholine; 30) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-6-(R)-methyl-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 31 ) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-6-(R)-methyl-4-(3-(5- oxo-1 H,4H-1 ,2,4-triazolo)methyl)-3-(S)-phenyl-moφholine; 32) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl- moφholine; 33) 4-(3-(l ,2,4-triazolo)methyl)-2-(S)-(3,5-bis(trifluoro- methyl)benzyloxy)-3-(R)-phenyl-moφholine; 34) 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-2-(S)-(3,5-bis- (trifluoromethyl)benzyloxy)-3-(R)-phenyl-moφholine; 35) 4-(2-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoro-methyl)- benzyloxy)-3-(R)-phenyl-moφholine; 36) 4-(4-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(R)-phenyl-moφholine; 37) 4-(aminocarbonylmethyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(R)-phenyl-moφholine; 38) 4-(2-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-moφholine; 39) 4-(4-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-moφholine; 40) 4-(2-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-6-(R)-methyl-moφholine; 41) 4-(4-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-6(R)-methyl-moφholine; 42) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-((6-hydroxy)-hexyl)- 3-(R)-phenyl-moφholine; 43) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(5-(methylamino- carbonyl)pentyl)-3-(R)-phenyl-moφholine; 44) 4-(3-(l ,2,4-triazolo)methyl)-2-(3,5-dimethylbenzyloxy)-3- phenylmoφholine; 45) 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-2-(3,5-dimethyl)- benzyloxy)-3-phenyl-moφholine; 46) 4-(3-(l ,2,4-triazolo)methyl)-2-(3,5-di(tert-butyl)- benzyloxy)-3-phenylmoφholine; 47) 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-2-(3,5-di(tert-butyl)- benzyloxy)-3-phenyl-moφholine; 48) 4-(3-(l ,2,4-triazolo)methyl)-2-(3-(tert-butyl)-5-methyl- benzyloxy)-3-phenyl-moφholine; 49) 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-2-(3-(tert-butyl)-5- methylbenzyloxy)-3-phenyl-moφholine; 50) 4-(3-(l ,2,4-triazolo)methyl)-2-(3-(trifluoro-methyl)-5- methyl-benzyloxy)-3-phenyl-moφholine; 51) 4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)-2-(3-(trifluoro- methyl)-5-methylbenzyloxy)-3-phenyl-moφholine; 52) 4-(3-( 1 ,2,4-triazolo)methyl)-2-(3-(tert-butyl)-5-(trifluoro- methyl)benzyloxy)-3-phenyl-moφholine; 53) 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-2-(3-(tert-butyl)-5- (trifluoromethyl)benzyloxy)-3-phenyl-moφholine; 54) 4-(2-(imidazolo)methyl)-2-(3,5-dimethyl-benzyloxy)-3-phenyl- moφholine; 55) 4-(4-(imidazolo)methyl)-2-(3,5-dimethyl-benzyloxy)-3-phenyl- moφholine; 56) 4-(2-(imidazolo)methyl)-2-(3,5-di(tert-butyl)-benzyloxy)-3- phenyl-moφholine; 57) 4-(4-(imidazolo)methyl)-2-(3,5-di(tert-butyl)-benzyloxy)-3- phenyl-moφholine; 58) 4-(2-(imidazolo)methyl)-2-(3-(tert-butyl)-5-methylbenzyloxy)-3- phenyl-moφholine; 59) 4-(4-(imidazolo)methyl)-2-(3-(tert-butyl)-5-methylbenzyloxy)-3- phenyl-moφholine; 60) 4-(2-(imidazolo)methyl)-2-(3-(trifluoro-methyl)-5-methyl- benzyloxy)-3-phenyl-moφholine; 61) 4-(4-(imidazolo)methyl)-2-(3-(trifluoro-methyl)-5-methyl- benzyloxy)-3-phenyl-moφholine; 62) 4-(2-(imidazolo)methyl)-2-(3-(tert-butyl)-5-(trifluoromethyl)- benzyloxy)-3-phenyl-moφholine; 63) 2-(S)-(3,5-dichlorobenzyloxy)-3-(S)-phenyl-moφholine; 64) 2-(S)-(3,5-dichlorobenzyloxy)-4-(3-(5-oxo-lH,4H-l ,2,4- triazolo)methyl)-3-(S)-phenylmoφholine; 65) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(methoxycarbonyl- methyl)-3-(S)-ρhenyl-moφholine; 66) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(carboxymethyl)-3- (S)-phenyl-moφholine; 67) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-((2-aminoethyl)- aminocarbonylmethyl)-3-(S)-phenyl-moφholine; 68) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-((3-aminopropyl)- amino carbonylmethyl)-3-(S)-phenylmoφholine; 69) 4-benzyl-5-(S),6-(R)-dimethyl-3-(S)-phenylmoφholinone and 4- benzyl-5-(R),6-(S)-dimethyl-3-(S)-phenyl-moφholinone; 70) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-[5-(S),6-(R) or 5- (R),6-(S)-dimethyl]-3-(S)-phenyl-moφholinone; 71) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-[5-(R),6-(S) or 5- (S),6-(R)-dimethyl]-3-(S)-phenyl-moφholinone; 72) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(l ,2,4- triazolo)methyl)-[5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3-(S)- phenyl-moφholinone; 73) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(5-oxo-lH,4H- 1,2,4-triazolo) methyl)-[5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3- (S)-phenyl-moφholinone; 74) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(l ,2,4- triazolo)methyl)-[5-(R),6-(S) or 5-(S),6-(R)-dimethyl]-3-(S)- phenyl-moφholinone; 75) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(5-oxo-lH,4H- l,2,4-triazolo)methyl)-[5-(R),6-(S) or 5-(S),6-(R)-dimethyl]-3- (S)-phenyl-moφholinone; 76) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(2-(l-(4-benzyl)- piperidino)ethyl)-3-(S)-phenyl-moφholine; 77) 3-(S)-(4-fluorophenyl)-4-benzyl-2-moφholinone; 78) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluoro- phenyl)-4-benzyl-moφholine; 79) 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluorophenyl) moφholine; 80) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluoro- phenyl)-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl-moφholine; 81 ) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-((3-pyridyl)methyl carbonyl)-3-(R)-phenyl-moφholine; 82) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(methoxycarbonyl- pentyl)-3-(R)-phenyl-moφholine; 83) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(carboxypentyl)-3- (R)-phenyl-moφholine; 84) 2-(S)-(3 ,5-bis(trifluoromethy l)benzy loxy)-4-(methylamino- carbonylpentyl)-6-oxo-hexyl)-3-(R)-phenyl-moφholine; 85) 2-(R)-(3,5-bis(trifluoromethyl)benzoyloxy)-3-(S)-phenyl-4- benzyl-moφholine; 86) 2-(R)-(l -(3,5-bis(trifluoromethyl)phenyl)ethenyloxy)-3-(S)- phenyl-4-benzyl-moφholine; 87) 2-(R)-(l-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 88) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)- pheny 1-moφholine ; 89) 2-(R)-(l-(S)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 90) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl-moφholine; 91) 2-(R)-(3,5-bis(trifluoromethyl)benzoyloxy)-3-(S)-(4-fluoro)- phenyl-4-benzyl-moφholine; 92) 2-(R)-(l-(3,5-bis(trifluoromethyl)phenyl)ethenyloxy)-3-(S)-(4- fluoro)phenyl-4-benzyl-moφholine; 93) 2-(R)-(l-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 94) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S) -(4- fluoro)phenyl-moφholine; 95) 2-(R)-(l-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 96) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 97) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl-moφholine; 98) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl-moφholine; 99) 2-(R)-(l -(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-moφholine; 100) 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 101) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-moφholine; 102) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 103) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 104) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφholine; 105) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 106) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 107) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 108) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)-moφholine; 109) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 110) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 111) 2-(R)-(l -(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 112) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 113) 2-(R)-(l-(R)-(3-(isoproρoxy)-5-trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-moφholine; 114) 2-(R)-(l-(R)-(3-(isoproρoxy)-5-trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 115) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 116) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3 -(5-oxo- lH,4H-l ,2,4-triazolo)methyl)-moφho line; 117) 2-(R)-(l -(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 118) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3 -(5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφholine; 119) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 120) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 121) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 122) 2-(R)-(l -(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)-moφholine; 123) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-moφholine; 124) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 125) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 126) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(3 -(5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφholine; 127) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 128) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(3 -(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 129) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-ρhenyl-moφholine; 130) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 131) 2-(R)-( 1 -(R)-(3 ,5-bis(trifluoromethy l)-4-chloro)pheny l)ethoxy)- 3-(S)-phenyl-moφholine; 132) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-chloro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methy 1)- moφholine; 133) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 134) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφholine; 135) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 136) 2-(R)-(l -(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφholine; 137) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-phenyl-moφholine; 138) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methylmoφholine; 139) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 140) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1H,4H-1 ,2,4-triazolo)methyl)-moφholine; 141) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 142) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφholine; 143) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 144) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 145) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 146) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 147) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-moφholine; 148) 2-(R)-(l -(R)-(l -(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)-moφholine; 149) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-hydroxy)- phenyl-moφholine; 150) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-hydroxy)- phenyl-4-(3 -(5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφho line; 151) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl- moφholine; 152) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-moφholine; 153) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- pheny 1-moφholine ; 154) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 155) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 156) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 157) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 158) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 159) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- (5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 160) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 161) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 162) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H-1 ,2,4-triazolo)methyl)- moφholine; 163) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 164) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 165) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 166) 2-(R)-(l -(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 167) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 168) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 169) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-imidazolo)methyl-moφholine; 170) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 171) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 172) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 173) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-imidazolo)methyl-moφholine; 174) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 175) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 176) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 177) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(5-tetrazolo)methyl-moφholine; 178) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 179) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- oxo-5H-pyrrol-4-yl)methyl-moφholine; 180) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 181) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 182) 2-(R)-(l -(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 183) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl- moφholine; 184) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-moφholine; 185) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-moφholine; 186) 2-(R)-(l -(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-moφholine; 187) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-ρhenyl-4-(3- ( 1 ,2,4-triazolo)methy 1-moφholine; 188) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 189) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 190) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 191) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- (5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφholine; 192) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 193) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 194) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 195) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- (2-oxo- l,3-imidazolo)methyl)-moφholine; 196) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 197) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 198) 2-(R)-(l -(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 199) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- imidazolo)methyl)-moφholine; 200) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl)-moφholine; 201 ) 2-(R)-(l -(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-imidazolo)methyl)-moφholine; 202) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(2-imidazolo)methyl)-moφholine; 203) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- imidazolo)methyl)-moφholine; 204) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 205) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-imidazolo)methyl-moφholine; 206) 2-(R)-( 1 -(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 207) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 208) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 209) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(5-tetrazolo)methyl-moφholine; 210) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 211) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- oxo-5H-pyrrol-4-yl)methyl-moφholine; 212) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 213) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 214) 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 215) 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-moφholine; 216) 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 217) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-moφholine; 218) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 219) 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(3-(l ,2,4- triazolo)methyl)-moφholine; 220) 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(l ,2,4- triazolo)methyl)-moφholine; 221) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl)-moφholine; 222) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l ,2,4-triazolo)methyl)-moφholine; 223) 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo- 1,2,4- triazolo)methyl)-moφholine; 224) 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- l ,2,4-triazolo)methyl)-moφholine; 225) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl)-moφholine; 226) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo- 1 ,2,4-triazolo)methyl)-moφholine; 227) 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo-l ,3- imidazolo)methyl)-moφholine; 228) 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 229) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 230) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 231 ) 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 232) 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)ρhenyl-4-(2- imidazolo)methyl-moφholine; 233) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 234) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine; 235) 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 236) 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 237) 2-(R)-(l -(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 238) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 239) 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholine; 240) 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 241) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 242) 2-(R)-(l -(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-moφholine; 243) 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- yl)methyl-moφholine; 244) 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 245) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 246) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 247) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-moφholine; 248) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 249) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-moφholine; 250) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 251) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 252) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 253) 2-(R)-(l -(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(3-(l ,2,4- triazolo)methyl-moφholine; 254) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l ,2,4-triazolo)methyl-moφholine; 255) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo-lH,4H- 1 ,2,4-triazolo)methyl-moφholine; 256) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl-moφholine; 257) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 258) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 259) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo-l ,3- imidazolo)methyl)-moφholine; 260) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 261) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- l,3-imidazolo)methyl)-moφholine; 262) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 263) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 264) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 265) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 266) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine; 267) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 268) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 269) 2-(R)-(l -(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 270) 2-(R)-( 1 -(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 271 ) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholine; 272) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 273) 2-(R)-(l -(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 274) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-moφholine; 275) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- y l)methy 1-moφholine ; 276) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 277) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 278) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 279) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-moφholine; 280) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 281) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-moφholine; 282) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 283) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(3-(l ,2,4- triazolo)methyl)-moφholine; 284) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4- triazolo)methyl)-moφholine; 285) 2-(R)-(l -(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(3-(l ,2,4- triazolo)methyl)-moφholine; 286) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl)-moφholine; 287) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo-lH,4H- l,2,4-triazolo)methyl)-moφholine; 288) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 289) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H-1 ,2,4-triazolo)methyl)-moφholine; 290) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 291) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo-l,3- imidazolo)methyl)-moφholine; 292) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 293) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 294) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 295) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 296) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 297) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 298) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine; 299) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 300) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 301) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 302) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 303) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholine; 304) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 305) 2-(R)-(l -(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 306) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-moφholine; 307) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- yl)methyl-moφholine; 308) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 309) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 310) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 311) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-moφholine; 312) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl- moφholine; 313) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl- moφholine; 314) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 315) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3-lH,4H- 1 ,2,4-triazolo)methyl-moφholine; 316) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3- 1 H,4H- 1 ,2,4-triazolo)methyl-moφholine; 317) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (3-lH,4H-l,2,4-triazolo)methyl-moφholine; 318) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl-moφholine; 319) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo)- 1 H,4H- 1 ,2,4-triazolo)methy l)-moφholine; 320) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3- (5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 321) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 322) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)- moφholine; 323) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 324) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 325) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methy l)-moφholine; 326) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l ,3-imidazolo)methyl)-moφholine; 327) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 328) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 329) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (2-imidazolo)methyl-moφholine; 330) 2-(R)-(l -(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 331 ) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 332) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 333) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (4-imidazolo)methyl-moφholine; 334) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 335) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 336) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 337) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (5-tetrazolo)methyl-moφholine; 338) 2-(R)-(l -(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 339) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 340) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- oxo-5H-ρyrrol-4-yl)methyl-moφholine; 341) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 342) 2-(R)-( 1 -(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 343) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-moφholine; 344) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 345) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-moφholine; 346) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 347) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(3-(l ,2,4- triazolo)methyl-moφholine; 348) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(l ,2,4- triazolo)methyl-moφholine; 349) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 350) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl-moφholine; 351) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo-lH,4H- 1 ,2,4-triazolo)methyl-moφholine; 352) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- lH,4H-l,2,4-triazolo)methyl-moφholine; 353) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methy l)-moφholine; 354) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 355) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo-l ,3- imidazolo)methyl-moφholine; 356) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 357) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 358) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 359) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 360) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 361) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 362) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine; 363) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 364) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 365) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 366) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 367) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholine; 368) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 369) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 370) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-moφholine; 371) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- yl)methyl-moφholine; 372) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 373) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 374) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 375) 4-(4-(imidazolo)methyl)-2-(3-(tert-butyl)-5-(trifluoromethyl)- benzyloxy)-3-phenyl-moφholine; 376) 2-(R)-(2,5-bis(trifluoromethyl)benzoyloxy)-3-(S)-(4- fluorophenyl)-4-benzyl-moφholine; 377) 2-(R)-(l-(2,5-bis(trifluoromethyl)phenyl)ethenyloxy)-3-(S)-(4- fluorophenyl)-4-benzyl-moφholine; 378) 2-(R)-(l-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-moφholine; 379) 2-(R)-(l-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 380) 2-(R)-(l-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(3-(l,2,4-triazolo)methyl)-moφholine; 381) 2-(R)-(l-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 382) 2-(R)-(l -(R)-(3-(thiomethyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 383) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 384) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(3- ( 1 ,2,4-triazolo)methyl)-moφholine; 385) 2-(R)-(l -(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl)-moφholine; 386) 2-(R)-(l-(R)-(3-(thiomethyl)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-moφholine; 387) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 388) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 389) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 390) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyl-moφholine; 391) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 392) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl)-moφholine; 393) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3- imidazolo)methyl)-moφholine; 394) 2-(R)-(l -(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 395) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφholine; 396) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 397) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 398) 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)-ethoxy)-3- (S)-(4-fluorophenyl)-moφholine; 399) 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluorophenyl)-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 400) 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluorophenyl)-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 401) 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluorophenyl)-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 402) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)phenyl)-ethoxy)-3- (S)-(4-fluorophenyl)-moφholine; 403) 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 404) 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 405) 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 406) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 407) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 408) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 409) 2-(R)-(l -(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 410) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 411) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 412) 2-(R)-(l -(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 413) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 414) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 415) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 416) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 417) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 418) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 419) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 420) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 421) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 422) 2-(R)-(l -(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 423) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)- moφholine; 424) 2-(R)-(l -(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 425) 2-(R)-(l -(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 426) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-moφholine; 427) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluorometLyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l ,2,4- triazolo)methyl)-moφholine; 428) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 429) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 430) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 431) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 432) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 433) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 434) 2-(R)-(l-(R)-(3-(fluoro)-5-(isoproρoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 435) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3 -(5-oxo- 1 H,4H- 1 ,2,4-triazolo)metlιyl)- moφholine; 436) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 437) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 438) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 439) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 440) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 441) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 442) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)pheny 1-moφholine ; 443) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)- moφholine; 444) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 445) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(4-(2-oxo-l ,3-imidazolo)methyl)- moφholine; 446) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)pheny 1-moφholine ; 447) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3 -(5-oxo- 1H,4H-1 ,2,4-triazolo)methyl)- moφholine; 448) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 449) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 450) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 451) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)- moφholine; 452) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 453) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 454) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-moφholine; 455) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3_(S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4- triazolo)methyl)-moφholine; 456) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 457) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-l ,3-imidazolo)methyl)- moφholine; 458) 2-(R)-( 1 -(R)-(3 ,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-moφholine; 459) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l ,2,4- triazolo)methyl)-moφholine; 460) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 461) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 462) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 463) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3 -(5-oxo- 1H,4H-1 , 2,4-triazolo)methyl)- moφholine; 464) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 465) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 466) 2-(R)-(l -(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)pheny 1-moφholine ; 467) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 468) 2-(R)-(l -(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 469) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 470) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 471) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3- (5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 472) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 473) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4- (2-oxo-l , -imidazolo)methyl)-moφholine; 474) 2-(R)-(l -(R)-(l -(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 475) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 476) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)ρhenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 477) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 478) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 479) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 480) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 481) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 482) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 483) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 484) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 485) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 486) 2-(R)-(l -(R)-(l -(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 487) 2-(R)-(l-(R)-(l-(3-(methyi)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 488) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 489) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 490) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 491) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)- moφholine; 492) 2-(R)-(l -(R)-(l -(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 493) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 494) 2-(R)-(l-(R)-(3-(thiomethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)pheny 1-moφholine ; 495) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 496) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 497) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 498) 2-(R)-( 1 -(R)-(3-(thiomethyl)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-moφholine; 499) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4- triazolo)methyl)-moφholine; 500) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 501) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 502) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-moφholine; 503) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methy l)-moφholine; 504) 2-(R)-(l -(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4- triazolo)methyl)-moφholine; 505) 2-(R)-(l -(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-l,3- imidazolo)methyl)-moφholine; 506) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 507) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 508) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 509) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 510) 2-(R)-(l -(R)-(phenyl)ethoxy)-3-(S)-phenyl-moφholine; 511) 2-(R)-( 1 -(R)-(phenyl)ethoxy)-3 -(S)-phenyl-4-(3-(5-oxo- 1 H,4H- l,2,4-triazolo)methyl)-moφholine; 512) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl)-moφholine; 513) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-l,3- imidazolo)methyl)-moφholine; 514) 2-(R)-(l -(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl moφholine; 515) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5- oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 516) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4- triazolo)methyl)-moφholine; 517) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2- oxo- 1 ,3-imidazolo)methyl)-moφholine; 518) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-moφholine; 519) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 520) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl)-moφholine; 521) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo- 1 ,3-imidazolo)methyl)-moφholine; 522) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 523) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)-moφholine; 524) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl)-moφholine; 525) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 526) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-moφholine; 527) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 528) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(l ,2,4- triazolo)methyl)-moφholine; 529) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl)-moφholine; 530) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 531) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 532) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl)-moφholine; 533) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 534) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-moφholine; 535) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)- moφholine; 536) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 537) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 538) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-mθφholine; 539) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 540) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 541) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 542) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-moφholine ; 543) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 544) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 545) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(4-(2-oxo-l ,3-imidazolo)methyl)-moφholine; 546) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-moφholine; 547) 2-(R)-(l-(R)-(3,5-bis(tιifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(3-(5-oxo-l H,4H-1 ,2,4-triazolo)methyl)- moφholine; 548) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 549) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 550) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-moφholine; 551) 2-(R)-( 1 -(R)-(3 ,5-bis(trifluoromethyl)phenyl)ethoxy )-3 -(S)-3 ,4- methylenedioxyphenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 552) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 553) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 554) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-moφholine; 555) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 556) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(3-(l,2,4-triazolo)methyl)-moφholine; 557) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 558) 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 559) 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 560) 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 561) 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 562) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 563 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- l,3-imidazolo)methyl)-moφholine; 564) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(l,2,4-triazolo)methyl)-moφholine; 565) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methy l)-moφholine; 566) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(-lH,4H-l,2,4-triazolo)methyl)-moφholine; 567) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 568) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-ρhenyl- 4-(3-(l,2,4-triazolo)methyl)-moφholine; 569) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 570) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 571) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(4- (2-oxo-l, 3 -imidazolo)methyl)-moφholine; 572) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(-lH,4H-l,2,4-triazolo)methyl)-moφholine; 573) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 574) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(-lH,4H-l,2,4-triazolo)methyl)-moφholine; 575j 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 576) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(-lH,4H-l,2,4-triazolo)methyl)-moφholine; 577) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo-l ,3-imidazolo)methyl)-moφholine; 578) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 579) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methy l)-moφholine; 580) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(- 1 H,4H- 1 ,2,4-triazolo)methy l)-moφholine; 581) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 582) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 583) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 584) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(-lH,4H-l,2,4-triazolo)methyl)-moφholine; 585) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 586) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(-lH,4H-l,2,4-triazolo)methyl)-moφholine; 587) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 588) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(- 1 H,4H-1 ,2,4-triazolo)methyl)-moφholine; 589) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 590) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(- 1 H,4H- 1 ,2,4-triazolo)methy l)-moφholine; 591) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl)-moφholine; 592) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3- ( 1 ,2,4-triazolo)methyl)-moφholine; 593) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl)-moφholine; 594) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-phenyl-4-(3-(l ,2,4- triazolo)methyl)-moφholine; 595) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-l,3- imidazolo)methyl)-moφholine; 596) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 597) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- l,3-imidazolo)methyl)-moφholine; 598) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 599) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- l,3-imidazolo)methyl)-moφholine; 600) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 601) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- l,3-imidazolo)methyl)-moφholine; and pharmaceutically acceptable salts thereof. 17. The prodrug of Claim 16 wherein the prodrug comprises a phosphoryl group. 18. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount of the compound of Claim 1. 19. The pharmaceutical composition of Claim 18 wherein the pharmaceutically acceptable carrier comprises water. 20. The pharmaceutical composition of Claim 18 wherein the pharmaceutically acceptable carrier comprises a physiologically acceptable saline solution. 21. A method for antagonizing the effect of substance P at its receptor site or for the blockade of neurokinin- 1 receptors in a mammal which comprises the administration to the mammal of the compound of Claim 1 in an amount that is effective for antagonizing the effect of substance P at its receptor site in the mammal. 22. A method of treating or preventing pain or nociception attributable to or associated with migraine in a mammal in need thereof which comprises the administration to the mammmal of an effective amount of the compound of Claim 1. 23. A method of treating or preventing a condition selected from the group consisting of: diabetic neuropathy; peripheral neuropathy; AIDS related neuropathy; chemotherapy-induced neuropathy; and neuralgia, in a mammal in need thereof which comprises the administration to the mammal of an effective amount of the compound of Claim 1. 24. A method for the treatment or prevention of asthma in a mammal in need thereof which comprises the administration to the mammal of an effective amount of the compound of Claim 1 , either alone or in combination with a neurokinin-2 receptor antagonist or with a β2-adrenergic receptor agonist. 25. A method for the treatment of cystic fibrosis in a mammal in need thereof which comprises the administration to the mammal of an effective amount of the compound of Claim 1. 26. A method for the treatment or prevention of emesis in a mammal in need thereof which comprises the administration to the mammal of an effective amount of the compound of Claim 1. 27. A method for the treatment or prevention of arthritis in a mammal in need thereof which comprises the administration to the mammal of an effective amount of the compound of Claim 1. 28. A process for the preparation of a compound of the structural formula I: or a pharmaceutically acceptable salt thereof, wherein: R2 and R3 are independently selected from the group consisting of: (1) hydrogen, (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR9R 10, wherein R9 and R 1 are independently selected from: (i) hydrogen, (ii) Cl-6 alkyl, (iii) hydroxy-Cl-6 alkyl, and (iv) phenyl, (i) -NR9COR10, wherein R9 and RlO are as defined above, (j) -NR9CO2R10, wherein R9 and RlO are as defined above, (k) -CONR9R 10, wherein R9 and R 10 are as defined above, (1) -COR9, wherein R9 is as defined above, and (m) -C02R9, wherein R9 is as defined above; (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR9R 10 wherein R9 and R 10 are as defined above, (i) -COR9 wherein R9 is as defined above, (j) -C02R9, wherein R9 is as defined above; (4) C2-6 alkynyl; (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) Cl-6 alkoxy, (c) Cl-6 alkyl, (d) C2-5 alkenyl, (e) halo, (f) -CN, (g) -N02, (h) -CF3, (i) -(CH2)m-NR9RlO, wherein m, R9 and RlO are as defined above, (j) -NR9COR 10, wherein R9 and R 10 are as defined above, (k) -NR9C02R 10, wherein R9 and R 10 are as defined above, (1) -CONR9R10, wherein R9 and RlO are as defined above, (m) -CO2NR9R10, wherein R9 and RlO are as defined above, (n) -COR9, wherein R9 is as defined above; (o) -C02R9, wherein R9 is as defined above; and, alternatively, the groups R2 and R3 are joined together to form a carbocyclic ring selected from the group consisting of: (a) cyclopentyl, (b) cyclohexyl, (c) phenyl, and wherein the carbocyclic ring is unsubstituted or substituted with one or more substituents selected from: (i) Ci-6alkyl, (ii) Ci-6alkoxy, (iii) -NR9R 10, wherein R9 and R 10 are as defined above, (iv) halo, and v) trifluoromethyl; and, alternatively, the groups R2 and R3 are joined together to form a heterocyclic ring selected from the group consisting of: (a) pyrrolidinyl, (b) piperidinyl, (c) pyrrolyl, (d) pyridinyl, (e) imidazolyl, (f) furanyl, (g) oxazolyl, (h) thienyl, and (i) thiazolyl, and wherein the heterocyclic ring is unsubstituted or substituted with one or more substituent(s) selected from: (i) Cl-6alkyl, (ii) oxo, (iii) Cl-6alkoxy, (iv) -NR9R 10, wherein R9 and R 10 are as defined above, (v) halo, and (vi) trifluoromethyl; (n) -COR9, wherein R9 is as defined above; (o) -C02R9, wherein R9 is as defined above; (6) halo, (7) -CN, (8) -CF3, (9) -N02, (10 -SR14, wherein Rl4 is hydrogen or Ci-5alkyl, (11 -SOR14, wherein Rl4 is as defined above, (12 -Sθ2Rl4, wherein Rl4 is as defined above, (13 NR9COR10, wherein R9 and RlO are as defined above, (14 CONR9COR10, wherein R9 and RlO are as defined above, (15 NR9R10, wherein R9 and RlO are as defined above, (16 NR9CO2R10, wherein R9 and RlO are as defined above, (17 hydroxy, (18 Cl-6alkoxy, (19 COR9, wherein R9 is as defined above, (20 C02R9, wherein R9 is as defined above, (21 2-pyridyl, (22 3-pyridyl, (23 4-pyridyl, (24 5-tetrazolyl, (25 2-oxazolyl, and (26 2-thiazolyl; Rl 1 , Rl2 and Rl3 are independently selected from the definitions of R6, R7 and R8, or -OX; A is selected from the group consisting of: (1) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Ci-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, wherein halo is fluoro, chloro, bromo or iodo, (h) -NR9R10, wherein R9 and RlO are as defined above, (i) -NR9COR 10, wherein R9 and R 10 are as defined above, (j) -NR9C02R 10, wherein R9 and R 10 are as defined above, (k) -CONR9R 10, wherein R9 and RlO are as defined above, (1) -COR9, wherein R9 is as defined above, and (m) -C02R , wherein R9 is as defined above; (2) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR9R 10 wherein R9 and R 10 are as defined above, (i) -COR9 wherein R9 is as defined above, and (j) -C02R , wherein R9 is as defined above; and (3) C2-6 alkynyl; B is a heterocycle, wherein the heterocycle is selected from the group consisting of: H H N-N N-N N O N ,x N-N N-N r N ■ N X N-N N=N y N A , and wherein the heterocycle is substituted in addition to -X with one or more substituent(s) selected from: (i) hydrogen; (ii) Cl-6 alkyl, unsubstituted or substituted with halo, -CF3, -OCH3, or phenyl, (iii) Cl-6 alkoxy, (iv) oxo, (v) hydroxy, (vi) thioxo, (vii) -SR9, wherein R9 is as defined above, (viii) halo, (ix) cyano, (x) phenyl, (xi) trifluoromethyl, (xii) -(CH2)m-NR9RlO, wherein m is 0, 1 or 2, and R9 and RlO are as defined above, (xiii) -NR9COR10, wherein R9 and RlO are as defined above, (xiv) -CONR9R10, wherein R9 and RlO are as defined above, (xv) -C02R9, wherein R9 is as defined above, and (xvi) -(CH2)m-OR9, wherein m and R9 are as defined above; p is 0 or 1; X is selected from: (a) -PO(OH)0 _ • M+, wherein M+ is a pharmaceutically acceptable monovalent counterion, (b) -PO(0-)2 • 2M+, (c) -PO(0")2 • D2+, wherein D2+ is a pharmaceutically acceptable divalent counterion, (d) -CH(R4)-PO(OH)0- • M+, wherein R4 is hydrogen or C1-3 alkyl, (e) -CH(R4)-PO(0-)2 • 2M+, (f) -CH(R4)-PO(0-)2 • D2+, (g) -SO3- • M+, (i) -CO-CH2CH2-CO2- • M+, (j) -CH(CH3)-0-CO-R5, wherein R is selected from the group consisting of: (i) A NH 3 + M O ' ( ϋi ) A O C0 2 - M + (k) hydrogen, with the proviso that if p is 0 and none of Rl 1 , Rl2 or Rl3 are -OX, then X is other than hydrogen; Y is selected from the group consisting of: (1) a single bond, (2) -0-, (3) -S-, (4) -CO-, (5) -CH2-, (6) -CHRl -, and (7) -CR 15R 16-, wherein R 1 and R 16 are independently selected from the group consisting of: (a) Cl-6 alkyl, unsubstimted or substituted with one or more of the substituents selected from: (i) hydroxy, (ii) oxo, (iii) Cl-6 alkoxy, (iv) phenyl-Ci-3 alkoxy, (v) phenyl, (vi) -CN, (vii) halo, (viii) -NR9R10, wherein R9 and RlO are as defined above, (ix) -NR9COR 10, wherein R9 and R 10 are as defined above, (x) -NR9C02R ! °, wherein R9 and R 10 are as defined above, (xi) -CONR9R 10, wherein R9 and R 10 are as defined above, (xii) -COR9, wherein R9 is as defined above, and (xiii) -C02R9, wherein R9 is as defined above; (b) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (i) hydroxy, (ii) Cl-6 alkoxy, (iii) Cl-6 alkyl, (iv) C2-5 alkenyl, (v) halo, (vi) -CN, (vii) -N02, (viii) -CF3, (ix) -(CH2)m-NR9RlO, wherein m, R9 and RlO are as defined above, (x) -NR9COR 10, wherein R9 and R 10 are as defined above, (xi) -NR9C02R 1 °, wherein R9 and R 10 are as defined above, (xii) -CONR9R 10, wherein R9 and R 10 are as defined above, (xiii) -CO2NR9R10, wherein R9 and RlO are as defined above, (xiv) -COR9, wherein R9 is as defined above, and (xv) -C02R9, wherein R9 is as defined above; Z is selected from: (1) hydrogen, (2) Cl-6 alkyl, and (3) hydroxy, with the proviso that if Y is -0-, Z is other than hydroxy, or if Y is -CHR1 -, then Z and Rl5 are optionally joined together to form a double bond; which comprises contacting a compound of formula: wherein A, B, Y, Z, p, Rl, R , R3, R6 ? R7 ? R8, R1 1 ? R12 an d R13 are defined as above, with the exception that within such variables, X is hydrogen; with an appropriate prodrug transfer reagent and in the presence of a suitable base, for a sufficient time to produce the compound of structural formula I.

Inventors: DORN CONRAD P, HALE JEFFREY J, MACCOSS MALCOLM, MILLS SANDER G, DORN, CONRAD, P., HALE, JEFFREY, J., MACCOSS, MALCOLM, MILLS, SANDER, G.
Applicants: DORN CONRAD P, HALE JEFFREY J, MACCOSS MALCOLM, MERCK & CO INC, MILLS SANDER G, DORN, CONRAD, P., HALE, JEFFREY, J., MACCOSS, MALCOLM, MERCK & CO., INC., MILLS, SANDER, G.
Application year: 1995
Main classification: C07D413
IPC codes: A61K31, A61P1, A61P3, A61P11, A61P19, A61P25, A61P29, C07D265, C07D413, C07F9