DELTA <12,13>-ISO-TAXOL ANALOGS, ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Abstract: This invention provides 7-deoxy- DELTA <12,13>-iso-taxol analogs of formula (I). The compounds of formula (I) are useful for the treatment of the same cancers for which taxol has been shown active, including human ovarian cancer, breast cancer, and malignant melanoma as well as lung cancer, gastric cancer, colon cancer, head and neck cancer, and leukemia.

Description: Δ 1 13 -ISO-TAXOL ANALOGS, ANTINEOPLASΗC USE AND PHARMACEUΗCAL COMPOSITIONS CONTAINING THEM BACKGROUND OF THE INVENTION Taxol is a member of the taxane family of diterpenes, having the structure shown below: The numbering system shown for taxol is that recommended by IUPAC (IUPAC, Commission on the Nomenclature of Organic Chemistry, 1978). The chemistry of the potent anticancer diterpenoid taxol and analogs thereof is reviewed, with an emphasis on isolation and analysis, structural modifications, partial synthesis, and structure-activity relationships by David G.I. Kingston, The Chemistry of Taxol, Pharmac. Ther., Vol 52, pp 1-34, 1991. The clinical pharmacology of taxol is reviewed by Eric K. Rowinsky and Ross C. Donehower, The Clinical Pharmacology and Use of Antimicrotubule Agents in Cancer Chemotherapeutics, Pharmac. Ther., Vol 52, pp 35-84, 1991. Clinical and preclinical studies with taxol are reviewed by William J. Slichenmyer and Daniel D. Von Hoff, Taxol: A New and Effective Anti-cancer Drug, Anti-Cancer Drugs, Vol. 2, pp 519-530, 1991. Taxol and analogs thereof are the subject of various patents including, for example, U.S. Patent Nos. 4,814,470; 4,857,653; 4,942,184; 4,924,011; 4,924,012; 4,960,790; 5,015,744; 5,157,049; 5,059,699; 5,136,060; 4,876,399; 5,227,400, 5,248,796 as well as PCT Pubhcation No. WO 92/09589, European Patent Application 90305845.1 (Publication No. A2 0 400 971), 90312366.9 (Publication No. Al 0 428 376), 89400935.6 (Publication No. Al 0 366 841) and 90402333.0 (Publication No. 0 414 610 Al), 87401669.4 (Al 0 253 739), 92308608.6 (Al 0 534 708), 92308609.4 (Al 534 709) and PCT Pubhcation Nos. WO 91/17977, WO 91/17976, Various processes for the preparation of taxol (and intermediates and analogs thereof) are described in Tetrahedron Letters, 1992, 33, 5185; J. Org. Chem., 1991, 56, 1681 and J. Org. Chem., 1991, 56, 5114 as well as WO 94/07876, WO 94/07877, WO 94/07878 and WO 94/07879. See also US Patent 4,924,011 (and Reissue Patent 34,277, dated 8 June 1993) as well as Tetrahedron Letters 35, 4483 (1994). Chen et al., Serendipitous Synthesis of a Cyclopropane-Containing Taxol Analog via Anchimeric Participation of an Unactivated Angular Methyl Group, Advance ACS Abstracts, Vol 1, No. 2., July 15, 1993 reported the treatment of a 1-epi taxol derivative with DAST in dichloromethane led to an unexpected reaction involving participation of the C- 19 methyl group and clean formation of a cyclopropane ring. See also J. Org. Chem., 1993, 58, 4520 (August 13, 1993) and U.S. Patent 5,254,580 (granted 19 October 1993). U.S. Patent 5,248,796 (granted 28 September 1993) relates to 10-desacetoxy- 11,12- dihydrotaxol-10,12(18)-diene derivatives and the preparationof 10-desacetoxytaxol. EP Application 0 558 959 Al discloses various phosphonooxy and carbonate 2' taxol derivatives of taxol with increased water solubility. Water-soluble pro-taxol analogs are disclosed in Nicolaou, K.C.; Riemer, C; Kerr, M.A.; Rideout, D.; Wrasidlo, W., Nature 364:464-66 (1993). C-2 substituted benzoate analogs of taxol and their synthesis is described in J. Am. Chem. Soc. 1994, 116, 4097-98 and Bioorganic & Medical Chemistry Letters, Vol. 4, No. 3, 479-82, 1994, SUMMARY OF THE INVENTION This invention provides Δ 1 ,I3 -iso-taxol analogs of Formula I: The compounds of Formula I are useful for the treatment of the same cancers for which taxol has been shown active, including human ovarian cancer, breast cancer, and malignant melanoma as well as lung cancer, gastric cancer, colon cancer, head and neck cancer, and leukemia. CONVENTIONS FOR FORMULAS AND DEFINITIONS OF VARIABLES The chemical formulas representing various compounds or molecular fragments in the specification and claims may contain variable substituents in addition to expressly defined structural features. These variable substituents are identified by a letter or a letter followed by a numerical subscript, for example, "Z." or "Rj" where "i" is an integer. These variable substituents are either monovalent or bivalent, that is, they represent a group attached to the formula by one or two chemical bonds. For example, a group Z, would represent a bivalent variable if attached to the formula Groups Rj and R j would represent monovalent variable substituents if attached to the formula CH 3 -CH 2 -C(Rj)(R j )-H. When chemical formulas are drawn in a linear fashion, such as those above, variable substituents contained in parentheses are bonded to the atom immediately to the left of the variable substituent enclosed in parenthesis. When two or more consecutive variable substituents are enclosed in parentheses, each of the consecutive variable substituents is bonded to the immediately preceding atom to the left which is not enclosed in parentheses. Thus, in the formula above, both R j and R^ are bonded to the preceding carbon atom. Also, for any molecule with an established system of carbon atom numbering, such as taxol, these carbon atoms are designated as C,, where "i" is the integer corresponding to the carbon atom number. For example, C 6 represents the 6 position or carbon atom number in the nucleus as traditionally designated by those skilled in the art. Chemical formulas or portions thereof drawn in a linear fashion represent atoms in a linear chain. The symbol "-" in general represents a bond between two atoms in the chain. Thus CH 3 -O-CH 2 -CH(R i )-CH 3 represents a 2-substituted-l-methoxypropane compound. In a similar fashion, the symbol and the symbol ' =" represents a triple bond, e.g., Carbonyl groups are represented in either one of two ways: -CO- or -C(«O)-, with the former being preferred for simplicity. Chemical formulas of cyclic (ring) compounds or molecular fragments can be represented in a linear fashion. Thus, the compound 4-chloro-2-methylpyridine can be represented in linear fashion by N * =C(CH 3 )-CH~CC1-CH=C * H with the convention that the atoms marked with an asterisk (*) are bonded to each other resulting in the formation of a ring. Likewise, the cyclic molecular fragment, 4-(ethyl)-l-piperazinyl can be represented by -N'-(CH 2 ) 2 -N(C 2 H j )-CH 2 -C * H 2 . Similarly, 2-furyl can be represented by -C*-O-CH-CH-C*H- and 2-thienyl represented by -C*-S-CH=CH-C*H=. A rigid cyclic (ring) structure for any compounds herein defines an orientation with respect to the plane of the ring for substituents attached to each carbon atom of the rigid cyclic compound. For saturated compounds which have two substituents attached to a carbon atom which is part of a cyclic system, -C(X,)(X 2 )- the two substituents may be in either an axial or equatorial position relative to the ring and may change between axial/equatorial. However, the position of the two substituents relative to the ring and each other remains fixed. While either substituent at times may lie in the plane of the ring (equatorial) rather than above or below the plane (axial), one substituent is always above the other. In chemical structural formulas depicting such compounds, a substituent (X x ) which is "below" another substituent (X 2 ) will be identified as being in the alpha (α) configuration and is identified by a broken, dashed or dotted line attachment to the carbon atom, i.e., by the symbol " " or "...". The corresponding substituent attached "above" (X 2 ) the other (X,) is identified as being in the beta (β) configura¬ tion and is indicated by an unbroken line attachment to the carbon atom. When a variable substituent is bivalent, the valences may be taken together or separately or both in the definition of the variable. For example, a variable Rj attached to a carbon atom as -C(-Rj)- might be bivalent and be defined as oxo or keto (thus forming a carbonyl group (-CO-) or as two separately attached monovalent variable substituents α-Rj. j and B-R^. When a bivalent variable, Rj, is defined to consist of two monovalent variable substituents, the convention used to define the bivalent variable is of the form "α-R i . j :β-R i . k " or some variant thereof. In such a case both α-Rj. j and β-Rj. k are attached to the carbon atom to give -C(α-R i . j )(β-R i . k )-. For example, when the bivalent variable 1^, - -Re)- is defined to consist of two monovalent variable substituents, the two monovalent variable substituents are etc, giving -C(α-R 6 .,)(β-R 6 . 2 )-, .... -C(α-R fr9 )(β-R frl0 )-, etc. Likewise, for the bivalent variable R π , -C(-R π )-, two monovalent variable substituents are For a ring substituent for which separate α and β orientations do not exist (e.g. due to the presence of a carbon double bond in the ring), and for a substituent bonded to a carbon atom which is not part of a ring the above convention is still used, but the α and β designations are omitted. Just as a bivalent variable may be defined as two separate monovalent variable substituents, two separate monovalent variable substituents may be defined to be taken together to form a bivalent variable. For example, in the formula (C, and define arbitrarily a first and second carbon atom, respectively) Rj and R j may be defined to be taken together to form (1) a second bond between C, and or (2) a bivalent group such as oxa (-O-) and the formula thereby describes an epoxide. When Rj and R j are taken together to form a more complex entity, such as the group -X-Y-, then the orientation of the entity is such that C, in the above formula is bonded to X and C 2 is bonded to Y. Thus, by convention the designa¬ tion "... R j and R j are taken together to form -CH 2 -CH 2 -O-CO- ..." means a lactone in which the carbonyl is bonded to C 2 . However, when designated "... R j and Rj are taken together to form -CO-O-CH 2 -CH 2 -the convention means a lactone in which the carbonyl is bonded to C,. The carbon atom content of variable substituents is indicated in one of two ways. The first method uses a prefix to the entire name of the variable such as "C r C 4 ", where both "1" and "4" are integers representing the minimum and maximum number of carbon atoms in the variable. The prefix is separated from the variable by a space. For example, "C,-C 4 alkyl" represents alkyl of 1 through 4 carbon atoms, (including isomeric forms thereof unless an express indication to the contrary is given). Whenever this single prefix is given, the prefix indicates the entire carbon atom content of the variable being defined. Thus -C 4 alkoxycarbonyl describes a group CH 3 -(CH 2 ) n -O-CO- where n is zero, one or two. By the second method the carbon atom content of only each portion of the definition is indicated separately by enclosing the "C r C j " designation in parentheses and placing it immediately (no intervening space) before the portion of the definition being defined. By this optional conven¬ tion (C r C 3 )alkoxycarbonyl has the same meaning as - alkoxycarbonyl because the "C,-C 3 " refers only to the carbon atom content of the alkoxy group. Similarly while both - alkoxyalkyl and (Cι-C 3 )alkoxy(C 1 -C 3 )alkyl define alkoxyalkyl groups containing from 2 to 6 carbon atoms, the two definitions differ since the former definition allows either the alkoxy or alkyl portion alone to contain 4 or 5 carbon atoms while the latter definition limits either of these groups to 3 carbon atoms. When the claims contain a fairly complex (cyclic) substituent, at the end of the phrase naming/designating that particular substituent will be a notation in (parentheses) which will correspond to the same name/designation in one of the CHARTS which will also set forth the chemical structural formula of that particular substituent. The term "Boc" refers to C(O)O-t-butyl, "Troc" refers to C(O))CH 2 CCl 3 , TES refers to Si(Et) 3 , Ph refers to phenyl, Ac refers to C(O)CH 3 , and Bz refers to C(O)Ph. DETAILED DESCRIPTION OF THE INVENTION More specifically, this invention provides 7-deoxy-Δ 12,13 -iso-taxol analogs of general Formula I wherein: X 2 is selected from the group consisting of -H, -C,-C 4 alkyl, -C,-C 3 alkoxy (preferably -OCH 3 ), halo (preferably -Cl), -C,-C 3 alkylthio, -trifluoromethyl, -C j - dialkylamino, benzyloxymethyl, cyano, azide (N 3 ), or nitro; R, is selected from the group consisting of -CH 3 , -C 6 Hj or phenyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, C,-^ alkylthio, trifluoromethyl, Cj- dialkylamino, hydroxy or nitro, -2-furyl, 2-thienyl, 1-naphthyl, 2-naphthyl or 3,4-methylenedioxyphenyl; R 2 is selected from the group consisting of -H, -NHC(O)H,-NHC(O)C r C 10 alkyl (preferably -NHC(O)C 4 -C 6 alkyl), -NHC(O)phenyl, -NHC(O)phenyl substituted with one, 2 or 3 C,-C 4 alkyl, C r C 3 alkoxy, halo, -C 3 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, -NHC(O)C(CH 3 )=CHCH 3 , -NHC(O)OC(CH 3 ) 3 , -NHC(O)OCH 2 phenyl, -NH 2 , -NHSO 2 -4-methylphenyl, -NHC(O)(CH 2 ) 3 COOH, -NHC(O)-4-(SO 3 H)phenyl, -OH, -NHC(O)-l-adamantyl, -NHC(O)O-3-tetrahydrofuranyl, -NHC(O)O-4-tetrahydropyranyl, -NHC(O)CH 2 C(CH 3 ) 3 , -NHC(O)C(CH 3 ) 3 , -NHC(O)OC,-C 10 alkyl, -NHC(O)NHC,-C 10 alkyl, -NHC(O)NHPh, -NHC(O)NHPh substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, C j -C j alkylthio, trifluoromethyl, - dialkylamino, or nitro, -NHC(O)C 3 -C 8 cycloalkyl, -NHC(O)OC(CH 2 CH 3 ) 2 CH 3 , -NHC(O)OC(CH 3 ) 2 CH 2 Cl, -NHC(O)OC(CH 3 ) 2 CH 2 CH 3 , phthalimido, -NHC(O)- 1 -phenyl- 1 -cyclopentyl, -NHC(O)- 1 -methyl- 1 -cyclohexyl, -NHC(S)NHC(CH 3 ) 3 or -NHC(O)NHCC(CH 3 ) 3 ; R 3 is selected from the group consisting of -H, -NHC(O)phenyl or -NHC(O)OC(CH 3 ) 3 , with the overall proviso that one of R 2 and R 3 is -H but R 2 and R 3 are not both -H; R 4 is -H or selected from the group consisting of -OH, -OAc (-OC(O)CH 3 ), -OC(O)OCH 2 C(Cl) 3 , -OCOCH 2 CH 2 NH 3 + HCOO\ -NHC(O)phenyl, -NHC(O)OC(CH 3 ) 3 , -OCOCH 2 CH 2 COOH and pharmaceutically acceptable salts thereof, -OCO(CH 2 ) 3 COOH and pharmaceutically acceptable salts thereof, and -OC(O)-Z-C(O)-R' [where Z is ethylene (-CH 2 CH 2 -), propylene (-CH 2 CH 2 CH 2 -), -CH-CH-, 1,2-cyclohexane or 1,2-phenylene, R' is -OH, -OH base, -NR' 2 R' 3 , -OR' 3 , -SR' 3 , -OCH 2 C(O)NR' 4 R' s where R' 2 is -H or -CH 3 , R' 3 is X " where n is 1-3, R' 4 is -H or -C,-C 4 alkyl, R' 5 is -H, -C r C 4 alkyl, benzyl, hydroxyethyl, -CH 2 CO 2 H or dimethylaminoethyl, R' 6 and R' 7 are -CH 3 , -CH 2 CH 3 , benzyl or R' 6 and R' 7 together with the nitrogen of NR'gR', form a pyrrolidino, piperidino, morpholino, or N-methylpiperizino group; R' 8 is -CH 3 , -CH 2 CH 3 or benzyl , X ' is halide, and base is NH 3 , (HOC^N, N(CH 3 ) 3 , CH^ H^NH, NH 2 (CH 2 ) 6 NH 2 , N-methylglucamine, NaOH or KOH], -OC(O)(CH 2 ) n NR 2 R 3 [where n is 1-3, R 2 is -H or -C,-C 3 alkyl and R 3 -H or -C r C 3 alkyl], -OC(O)CH(R")NH 2 [where R" is selected from the group consisting of -H, -CH 3 , -CH 2 CH(CH 3 ) 2 , -CH(CH 3 )CH 2 CH 3 , -CH(CH 3 ) 2 , -CH^henyl, -(CH 2 ) 4 NH 2 , -CH 2 CH 2 COOH, -(CH 2 ) 3 NHC(«NH)NH 2 ], the residue of the amino acid proline, -OC(O)CH-CH 2 , -C(O)CH 2 CH 2 C(O)NHCH 2 CH 2 SO 3 . Y + , -OC(O)CH 2 CH 2 C(O)NHCH 2 CH 2 CH 2 SO 3 Υ + wherein Y + is Na + or N + (Bu) 4 , -OC(O)CH 2 CH 2 C(O)OCH 2 CH 2 OH; R j is -H or -OH, with the overall proviso that when R 5 is -OH, R 4 is -H and with the further proviso that when R 5 is -H, R 4 is other than -H; Re is -H:-H when R 7 is α-R^β-R^ where one of R 71 and R 72 is -H and the other of R 71 and R T; , is -X 7 where X 7 is halo or azido (-N 3 ) and R 8 is -CH 3 ; Re is -H:-H when R 7 is α-H:β-R 74 where R 74 and R 8 are taken together to form a cyclopropyl ring; R β is RβjiRββ when R 7 is R 7J :R 76 where one of R^ and R^ is taken together with one of R 7J and R 76 to form a second bond between the carbon atoms to which they are attached and the other of R^ and R^ is -H, and the other of R 7J and R 76 is -H and where R 8 is -CH 3 ; Re is -H:-H when R 7 is α-R 81 :β-R 82 where one of R 81 and R 82 is -H and the other of R 81 and R 82 is -OH or -H and R 8 is -CH 3 ; Re is -H:-H when R 7 is α-R^β-R where one of R^ and Rgj is -H and the other of Rg, and R JZ is -W where W is selected from the group consisting of -OC(O)H, -O-C r C 6 alkyl, -O- C 3 -C 6 cycloalkyl, -©-(CH^henyl where n is 1-6, -O-C(O)C r C 10 alkyl, -O-C(O)phenyl, -O- C(O)phenyl substituted with one, 2 or 3 C r C 4 alkyl, C,-C 3 alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, - dialkylamino, or nitro, -O-C(O)naphthyl, -O-C(O)naphthyl substituted with one, 2 or 3 C,-C 4 alkyl, C,-C 3 alkoxy, halo, Cj- alkylthio, trifluoromethyl, - dialkylamino, or nitro, -O-C(O)Ophenyl, -O-C(O)Ophenyl substituted with one, 2 or 3 - alkyl, C,-C 3 alkoxy, halo, - alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, - O-C(O)Onaphthyl, -O-C(O)Onaphthyl substituted with one, 2 or 3 C,-C 4 alkyl, C r C j alkoxy, halo, Ci- alkylthio, trifluoromethyl, - dialkylamino, or nitro, -O-C(O)OC r C 10 alkyl, -O- C(O)NHC r C 10 alkyl, -O-C(O)NHρhenyl, -O-C(O)NHphenyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, -C 3 alkylthio, trifluoromethyl, - dialkylamino, or nitro, -O-C(O)NHnaphthyl, -O-C(O)NHnaphthyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, C C 3 alkylthio, trifluoromethyl, - dialkylamino, or nitro, -O-C(O)OCH 2 CHCl 2 , -O-C(O)OCH 2 CCl 3 , -OSi(R 16 ) 3 [where R 16 , being the same or different, is selected from C r C 6 alkyl or cyclo(C 5 -C 8 )alkyl], -O-CH 2 -O-C,-C 6 alkyl, -O-CH 2 -O-(CH 2 ) n phenyl where n is 1-3, -O-CH 2 -O-(CH 2 )„phenyl substituted with one, 2 or 3 C,- C 4 alkyl, C r C 3 alkoxy, halo, - alkylthio, trifluoromethyl, - dialkylamino, or nitro and where n is 1-3, -O-CH 2 -O-CH 2 -CX q H 3 ^ where q - 0-3 and X is halogen, and R 8 is -CH 3 ; R 30 is -H, OH, or -OC(O)CH 3 ; and pharmaceutically acceptable salts thereof when the compound contains either an acidic or basic functional group. A preferred embodiment of the subject invention is compounds of Formula I where R, is phenyl or phenyl substituted with halo, R 2 is -NHC(O)C 6 H 5 , R 3 and R 5 are -H, R 4 is -OH, and R 30 is -OH or -OC(O)CH 3 . Another preferred embodiment of the subject invention is compounds of Formula I where R, is preferably phenyl or phenyl substituted with halo, R 2 is -NHC(O)OC(CH 3 ) 3 , R 3 and R 5 are -H, R 4 is -OH, and R 30 is -H or -COCH 3 . A preferred embodiment of the subject invention is compounds of Formula I where R, is preferably phenyl or phenyl substituted with halo, R 2 is -NHC(O)NHC(CH 3 ) 3 , R 3 and R 5 are -H, R 4 is -OH, and R 30 is -OH or -OCOCH 3 . An embodiment of the subject invention are compounds of Formula I where R, is selected from the group consisting of -CH 3 , -C 6 H 5 or phenyl substituted with one, 2 or 3 C C A alkyl, C r C 3 alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, C 2 - dialkylamino, hydroxy or nitro and R 2 is selected from the group consisting of -H, -NHC(O)H, -NHC(O)C r C 10 alkyl (preferably -NHC(O)C 4 -C 6 alkyl), -NHC(O)phenyl, -NHC(O)phenyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, -NHC(O)C(CH 3 )=CHCH 3 , -NHC(O)OC(CH 3 ) 3 , -NHC(O)OCH 2 phenyl, -NH 2 , -NHSO 2 -4-methylphenyl, -NHC(O)(CH 2 ) 3 COOH, -NHC(O)-4-(SO 3 H)phenyl, -OH, -NHC(O)-l-adamantyl, -NHC(O)O-3-tetrahydrofuranyl, -NHC(O)O-4-tetrahydropyranyl, -NHC(O)CH 2 C(CH 3 ) 3 , -NHC(O)C(CH 3 ) 3 , -NHC(O)OC r C 10 alkyl, -NHC(O)NHC r C 10 alkyl, -NHC(O)NHPh substituted with one, 2 or 3 C,-C 4 alkyl, C,-C 3 alkoxy, halo, C,-C 3 alkylthio, trifluoromethyl, - dialkylamino, or nitro. An embodiment of the subject invention are compounds of Formula I where X 2 is -H. An embodiment of the subject invention are compounds of Formula I where X 2 is -H; R j is selected from the group consisting of -CH 3 , -C 6 H 5 or phenyl substituted with one, 2 or 3 C r C 4 alkyl, - alkoxy, halo, - alkylthio, trifluoromethyl, - dialkylamino, hydroxy or nitro, -2-furyl, 2-thienyl, 1-naphthyl, 2-naphthyl or 3,4-methylenedioxyphenyl; R 2 is selected from the group consisting of -H, -NHC(O)H,-NHC(O)C r C, 0 alkyl (preferably -NHC(O)C 4 -C 6 alkyl), -NHC(O)ρhenyl, -NHC(O)phenyl substituted with one, 2 or 3 C,-C 4 alkyl, - alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, Cj- dialkylamino, hydroxy or nitro, -NHC(O)C(CH 3 )-CHCH 3 , -NHC(O)OC(CH 3 ) 3 , -NHC(O)OCH 2 phenyl, -NH 2 , -NHSO 2 -4-methylphenyl, -NHC(O)(CH 2 ) 3 COOH, -NHC(O)-4-(SO 3 H)phenyl, -OH, -NHC(O)-l-adamantyl, -NHC(O)O-3-tetrahydrofuranyl, -NHC(O)O-4-tetrahydropyranyl, -NHC(O)CH 2 C(CH 3 ) 3 , -NHC(O)C(CH 3 ) 3 , -NHC(O)OC r C 10 alkyl, -NHC(O)NHC r C 10 alkyl, -NHC(O)NHPh, -NHC(O)NHPh substituted with one, 2 or 3 C r C 4 alkyl, C,-C 3 alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, - dialkylamino, or nitro, -NHC(O)OC(CH 2 CH 3 ) 2 CH 3 , -NHC(O)OC(CH 3 ) 2 CH 2 Cl, -NHC(O)OC(CH 3 ) 2 CH 2 CH 3 , phthalimido, -NHC(O)-l-phenyl-l-cyclopentyl, -NHC(O)-l -methyl- 1-cyclohexyl, -NHC(S)NHC(CH 3 ) 3 or -NHC(O)NHCC(CH 3 ) 3 ; R 3 is selected from the group consisting of -H, -NHC(O)phenyl or -NHC(O)OC(CH 3 ) 3 , with the overall proviso that one of R 2 and R 3 is -H but R 2 and R 3 are not both -H; R 4 is -H or selected from the group consisting of -OH, -OAc (-OC(O)CH 3 ), -OC(O)OCH 2 C(Cl) 3 , -OCOCH 2 CH 2 NH 3 + HCOO, -NHC(O)phenyl, -NHC(O)OC(CH 3 ) 3 , -OCOCH 2 CH 2 COOH and pharmaceutically acceptable salts thereof, -OCO(CH 2 ) 3 COOH and pharmaceutically acceptable salts thereof, and -OC(O)-Z-C(O)-R' [where Z is ethylene (-CH 2 CH 2 -), propylene (-CH 2 CH 2 CH 2 -), -CH-CH-, 1,2-cyclohexane or 1,2-phenylene, R' is -OH, -OH base, -NR * 2 R' 3 , -OR' 3 , -SR' 3 , -OCH 2 C(O)NR' 4 R' 5 where R' 2 is -H or -CH 3 , R' 3 is -(CH 2 ) n NR'gR' 7 or (CH 2 ) n N + R'gR' 7 R' 8 X " where n is 1-3, R' 4 is -H or -C,-C 4 alkyl, R' 5 is -H, -C,-C 4 alkyl, benzyl, hydroxyethyl, -CH 2 CO 2 H or dimethylaminoethyl, R' 6 and R' 7 are -CH 3 , -CH 2 CH 3 , benzyl or R' 6 and R' 7 together with the nitrogen of NR'gR' 7 form a pyrrolidino, piperidino, morpholino, or N-methylpiperizino group; R' 8 is -CH 3 , -CH 2 CH 3 or benzyl , X ' is halide, and base is NH 3 , (HO H^N, N(CH 3 ) 3 , CH 3 N(C 2 H 4 ) 2 NH, NH 2 (CH 2 ) 6 NH 2 , N-methylglucamine, NaOH or KOH], -OC(O)(CH 2 ) n NR R 3 [where n is 1-3, R 2 is -H or -C r C 3 alkyl and R 3 -H or -C,-C 3 alkyl], -OC(O)CH(R")NH 2 [where R" is selected from the group consisting of -H, -CH 3 , -CH 2 CH(CH 3 ) 2 , -CH(CH 3 )CH 2 CH 3 , -CH(CH 3 ) 2 , -CHzphenyl, -(CH 2 ) 4 NH 2 , -CH 2 CH 2 COOH, -(CH 2 ) 3 NHC(-NH)NH 2 ], the residue of the amino acid proline, -OC(O)CH-CH 2 , -C(O)CH 2 CH 2 C(O)NHCH 2 CH 2 SO 3 . Y + , -OC(O)CH 2 CH 2 C(O)NHCH 2 CH 2 CH 2 SO 3 Υ + wherein Y + is Na + or N + (Bu) 4 , -OC(O)CH 2 CH 2 C(O)OCH 2 CH 2 OH; Rj is -H or -OH, with the overall proviso that when R 5 is -OH, R 4 is -H and with the further proviso that when R 5 is -H, R 4 is other than -H; Rg is -H:-H when R 7 is α-R^β-R^ where one of R 71 and R 72 is -H and the other of R 71 and R 72 is -X 7 where X 7 is halo or azido (-N 3 ) and R 8 is -CH 3 ; Rg is -H:-H when R 7 is α-H:β-R 74 where R 74 and R 8 are taken together to form a cyclopropyl ring; Rg is R :R g when R 7 is R 7J :R 76 where one of Rg 5 and Rgg is taken together with one of R 7J and R 76 to form a second bond between the carbon atoms to which they are attached and the other of Rg 5 and Rgg is -H, and the other of R 75 and R 76 is -H and where R 8 is -CH 3 ; Rg is -H:-H when R 7 is α-R 81 :β-R 82 where one of R 8] and R 82 is -H and the other of R 8I and R 82 is -OH or -H and R 8 is -CH 3 ; Rg is -H:-H when R 7 is is -H and the other of R g , and R^ is -W where W is selected from the group consisting of -OC(O)H, -O-C r C 6 alkyl, -O- Gs-Cgcycloalkyl, -O-(CH 2 )„phenyl where n is 1-6, -O-C(O)C,-C 10 alkyl, -O-C(O)phenyl, -O- C(O)phenyl substituted with one, 2 or 3 C,-C 4 alkyl, C r C 3 alkoxy, halo, C,-C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, or nitro, -O-C(O)naphthyl, -O-C(O)naphthyl substituted with one, 2 or 3 alkyl, C,-C 3 alkoxy, halo, -C 3 alkylthio, trifluoromethyl, - dialkylamino, or nitro, -O-C(O)Ophenyl, -O-C(O)Ophenyl substituted with one, 2 or 3 C,-C 4 alkyl, C j - alkoxy, halo, C,-C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, or nitro, - O-C(O)Onaphthyl, -O-C(O)Onaphthyl substituted with one, 2 or 3 C r C 4 alkyl, C C 3 alkoxy, halo, - alkylthio, trifluoromethyl, Cj-Cg dialkylamino, or nitro, -O-C(O)OC r C 10 alkyl, -O- C(O)NHC,-C 10 alkyl, -O-C(O)NHphenyl, -O-C(O)NHphenyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, - alkylthio, trifluoromethyl, -Cg dialkylamino, or nitro, -O-C(O)NHnaphthyl, -O-C(O)NHnaphthyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, or nitro, -O-C(O)OCH 2 CHCl 2 , -O-C(O)OCH 2 CCl 3 , -OSi(R 16 ) 3 [where R 16 is C,-Cgalkyl], -O-CH 2 -O-C r C 6 alkyl, -O-CH 2 -O-(CH 2 ) n phenyl where n is 1-3, -O-CH 2 -O-(CH 2 ) n phenyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, - alkylthio, trifluoromethyl, -Cg dialkylamino, or nitro and where n is 1-3, -O-CH 2 -O-CH 2 -CX q H h where q - 0-3 and X is halogen, and R 8 is -CH 3 ; R 30 is -H, OH, or -OC(O)CH 3 ; and pharmaceutically acceptable salts thereof when the compound contains either an acidic or basic functional group. A further embodiment of the subject invention are compounds of Formula I where X 2 is in the ortho, meta or para-position (preferably meta or para, more preferably the meta position) and is selected from the group consisting of -C r C 4 alkyl, -C 1 -C 3 alkoxy (preferably -OCH 3 ), halo (preferably -Cl), -Cj-C 3 alkylthio, trifluoromethyl, - -Cg dialkylamino, benzyloxymethyl, cyano. azide (N 3 ), or nitro. A still further embodiment of the subject invention are compounds of Formula I where X 2 is in the ortho, meta or para-position (preferably meta or para, more preferably the meta position) and is selected from the group consisting of -N 3 , -CN, -OCH 3 or -Cl. A still further embodiment of the subject invention are compounds of Formula I where X 2 is in the ortho, meta or para-position (preferably meta or para, more preferably the meta position) and is selected from the group consisting of -N 3 , -CN, -OCH 3 or -Cl and R x is phenyl or phenyl substituted with halo, R 2 is -NHC(O) H 5 , R 3 and R 5 are -H, R 4 is -OH, and R x is -OH or -OC(O)CH 3 . A further embodiment of the subject invention are compounds of Formula I where X 2 is in the ortho, meta or para-position (preferably meta or para, more preferably the meta position) and is selected from the group consisting of -N 3 , -CN, -OCH 3 or -Cl and R : is preferably phenyl or phenyl substituted with halo, R 2 is -NHC(O)OC(CH 3 ) 3 , R 3 and R 5 are -H, R 4 is -OH, and R 30 is -H or -COCH 3 . A preferred embodiment of the subject invention is compounds of Formula I where X 2 is -H and R. is phenyl or phenyl substituted with halo, R 2 is -NHC(O)C 6 H 5 , R 3 and R 5 are -H, R 4 is -OH, and R 30 is -OH or -OC(O)CH 3 . Another preferred embodiment of the subject invention is compounds of Formula I where X 2 is -H and R, is preferably phenyl or phenyl substituted with halo, R 2 is -NHC(O)OC(CH 3 ) 3 , R 3 and R 5 are -H, R 4 is -OH, and R 30 is -H or -COCH 3 . A preferred embodiment of the subject invention is compounds of Formula I where X 2 is -H and R, is preferably phenyl or phenyl substituted with halo, R 2 is -NHC(O)NHC(CH 3 ) 3 , R 3 and R 5 are -H, R 4 is -OH, and R 30 is -OH or -OCOCH 3 . An embodiment of the subject invention are compounds of Formula I where X 2 is -H and R, is selected from the group consisting of -CH 3 , -C 6 Hj or phenyl substituted with one, 2 or 3 Cj-C 4 alkyl, C,-Cj alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro and R 2 is selected from the group consisting of -H, -NHC(O)H, -NHC(O)C 1 -C 10 alkyl (preferably -NHC(O)C 4 -C 6 alkyl), -NHC(O)phenyl, -NHC(O)phenyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, C ] -C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, hydroxy or nitro, -NHC(O)C(CH 3 )-CHCH 3 , -NHC(O)OC(CH 3 ) 3 , -NHC(O)OCH 2 phenyl, -NH 2 , -NHSO 2 -4-methylphenyl, -NHC(O)(CH 2 ) 3 COOH, -NHC(O)-4-(SO 3 H)phenyl, -OH, -NHC(O)-l-adamantyl, -NHC(O)O-3-tetrahydrofuranyl, -NHC(O)O-4-tetrahydropyranyl, -NHC(O)CH 2 C(CH 3 ) 3 , -NHC(O)C(CH 3 ) 3 , -NHC(O)OC,-C 10 alkyl, -NHC(O)NHC,-C 10 alkyl, - NHC(O)NHPh substituted with one, 2 or 3 C r C 4 alkyl, C,-C 3 alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, or nitro. This invention also provides Δ • -iso-taxol analogs of general Formula Ha and Formula IUa and Formula IVa Formula Va and Formula Via wherein X 7 is selected from the group consisting of -F, -Br, -Cl, -I, or -N 3 ; and wherein W, R„ R 2 , R 3 , R 4 , Rj, R 30 and X 2 are as defined above. This invention also provides Δ 12,13 -iso-taxol analogs of general Formula π and Formula HI and Formula IV Formula V and Formula VI wherein X 7 is selected from the group consisting of -F, -Br, -Cl, -I, or -N 3 ; and wherein W, R„ R 2 , R 3 , R 4 , R j and R 30 are as defined above. An embodiment of the present invention are 7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol analogs of general Formula II (or ϋa) wherein: R, is selected from the group consisting of -CH 3 , -C 6 Hj or phenyl substituted with one, 2 or 3 C C 4 alkyl, C j -C 3 alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, hydroxy or nitro; R 2 is selected from the group consisting of -H, -NHC(O)C r C 10 alkyl (preferably -NHC(O)C 4 -C 6 alkyl), -NHC(O)phenyl, -NHC(O)phenyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, C C 3 alkylthio, trifluoromethyl, C Cg dialkylamino, hydroxy or nitro, -NHC(O)C(CH 3 )-CHCH 3 , -NHC(O)OC(CH 3 ) 3 , -NH 2 , -NHSO 2 -4-methylphenyl, -NHC(O)(CH 2 ) 3 COOH, -NHC(O)-4-(SO 3 H)phenyl, -OH, -NHC(O)-l-adamantyl, -NHC(O)O-3-tetrahydrofuranyl, -NHC(O)O-4-tetrahydropyranyl, -NHC(O)CH 2 C(CH 3 ) 3 , -NHC(O)C(CH 3 ) 3 , -NHC(O)OC,-C 10 alkyl, -NHC(O)NHC 1 -C 10 alkyl, -NHC(O)NHPh substituted with one, 2 or 3 C,-C 4 alkyl, C,-C 3 alkoxy, halo, - alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -NHC(O)C 3 -C 8 cycloalkyl; R 3 is selected from the group consisting of -H, -NHC(O)phenyl or -NHC(O)OC(CH 3 ) 3 , with the overall proviso that one of R 2 and R 3 is -H but R 2 and R 3 are not both -H; R 4 is -H or selected from the group consisting of -OH, -OAc (-OC(O)CH 3 ), -OC(O)OCH 2 C(Cl) 3 , -OCOCH 2 CH 2 NH 3 + HCOO , -NHC(O)phenyl, -NHC(O)OC(CH 3 ) 3 , -OCOCH 2 CH 2 COOH and pharmaceutically acceptable salts thereof, -OCO(CH 2 ) 3 COOH and pharmaceutically acceptable salts thereof, and -OC(O)-Z-C(O)-R' [where Z is ethylene (-CH 2 CH 2 -), propylene (-CH 2 CH 2 CH 2 -), -CH-CH-, 1,2-cyclohexane or 1,2-phenylene, R' is -OH, -OH base, -NR' 2 R' 3 , -OR' 3 , -SR * 3 , -OCH 2 C(O)NR' 4 R'j where R' 2 is -H or -CH 3 , R' 3 is -(CH 2 ) n NR'gR' 7 or (CH 2 ) n N + R'gR' 7 R' 8 X " where n is 1-3, R' 4 is -H or -C,-C 4 alkyl, R' 5 is -H, - - alkyl, benzyl, hydroxyethyl, -CH 2 CO 2 H or dimethylaminoethyl, R' 6 and R' 7 are -CH 3 , -CH 2 CH 3 , benzyl or R' 6 and R' 7 together with the nitrogen of NR'gR' 7 form a pyrrolidino, piperidino, morpholino, or N-methylpiperizino group; R' 8 is -CH 3 , -CH 2 CH 3 or benzyl , X ' is halide, and base is NH 3 , (HOC 2 H 4 ) 3 N, N(CH 3 ) 3 , CH 3 N(C 2 H 4 ) 2 NH, NH 2 (CH 2 )gNH 2 , N-methylglucamine, NaOH or KOH], -OC(O) (CH 2 ) n NR 2 R 3 [where n is 1-3, R 2 is -H or -C,-C 3 alkyl and R 3 -H or - - alkyl], -OC(O)CH(R")NH 2 [where R" is selected from the group consisting of -H, -CH 3 , -CH 2 CH (CH 3 ) 2 , -CH(CH 3 )CH 2 CH 3 , -CH(CH 3 ) 2 , -CH.phenyl, -(CH 2 ) 4 NH 2 , -CH 2 CH 2 COOH, -(CH 2 ) 3 NHC(-NH)NHJ, the residue of the amino acid proline, - OC(O)CH-CH 2 , -C(O)CH 2 CH 2 C(O)NHCH 2 CH 2 SO 3 " Y + , -OC(O)CH 2 CH 2 C(O)NHCH 2 CH 2 CH 2 SO 3 Υ + wherein Y + is Na + or N + (Bu) 4 , -OC(O)CH 2 CH 2 C(O)OCH 2 CH 2 OH; , R 5 is -H or -OH, with the overall proviso that when R 5 is -OH, R 4 is -H and with the further proviso that when R 5 is -H, R 4 is other than -H; R 30 is -H, -OH, or -O-C(O)CH 3 ; and pharmaceutically acceptable salts thereof when the compound contains either an acidic or basic functional group. A preferred embodiment of the subject invention is compounds of Formula II (or Ha) where R ] is phenyl or phenyl substituted with halo, R 2 is -NHC(O)C 6 H 5 , R 3 and R 5 are -H, and R 30 is -C(O)CH 3 . Another preferred embodiment of the subject invention is compounds of Formula II (or ϋa) where R, is preferably phenyl or phenyl substituted with halo, R 2 is -NHC(O)OC(CH 3 ) 3 , and R 3 , R 5 and R 30 are -OH. A further preferred embodiment of the subject invention is compounds of Formula π (or Ha) where R, is preferably phenyl or phenyl substituted with halo, R 2 is -NHC(O)OC(CH 3 ) 3 , and R 3 and R 5 are -H, and R 30 is -OC(O)CH 3 . Another preferred embodiment of the subject invention is compounds of Formula I where R, is preferably phenyl or phenyl substituted with halo, R 2 is -NHC(O)NHC(CH 3 ) 3 , R 3 and R 5 are -H, R 4 is -OH, and R 30 is -OH or -OCOCH 3 . Additional preferred embodiments of Formula II include: - The compound according to Formula π, namely 7-deoxy-7β,8β-methano-Δ I2,13 -iso-taxol; - The compound according to Formula π, namely 2'-[{(2,2,2-trichloroethyl)oxy>carbonyl]-7- deoxy-7β,8β-methano-Δ 1213 -iso-taxol; - The compound according to Formula π, namely 10-acetyl-7-deoxy-7β,8β-methano-Δ 12,13 -iso- taxotere; and - The compound according to Formula π, namely N-debenzoyl-n-(t-butyl)aminocarbonyl-7- deoxy-7β,8β-methano-Δ 1213 -iso-taxol. A preferred embodiment of the subject invention are compounds of Formula π (or Ha) where R, is preferably phenyl or phenyl substituted with halo, R 2 is -NHC(O)NHC(CH 3 ) 3 , R 3 and R j are -H, R 4 is -OH, and R 30 is -OH or -OCOCH 3 . Another embodiment of the present invention are 7-halo-Δ 12,13 -iso-taxol analogs of general Formula HI (or Iϋa) wherein: X 7 is selected from the group consisting of -F, -Br, -Cl, -I, or -N 3 ; R j is selected from the group consisting of -CH 3 , -C 6 H S or phenyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, C,-C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, hydroxy or nitro; R 2 is selected from the group consisting of -H, -NHC(O)phenyl, -NHC(O)phenyl substituted with one, 2 or 3 C C 4 alkyl, C r C 3 alkoxy, halo, -C, alkylthio, trifluoromethyl, - C 6 dialkylamino, hydroxy or nitro,-NHC(O)C(CH 3 )-CHCH 3 , -NHC(O)OC(CH 3 ) 3 , -NH 2 , -NHSO 2 -4-methylphenyl, -NHC(O)(CH 2 ) 3 COOH, -NHC(O)-4-(SO 3 H)phenyl, -OH, -NHC(O)-l-adamantyl, -NHC(O)O-3-tetrahydrofuranyl, -NHC(O)O-4-tetrahydropyranyl, -NHC(O)CH 2 C(CH 3 ) 3 , -NHC(O)C(CH 3 ) 3 , -NHC(O)OC r C 10 alkyl, -NHC(O)NHC r C 10 alkyl, -NHC(O)NHPh substituted with one, 2 or 3 C,-C 4 alkyl, C C 3 alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, or nitro, -NHC(O)C 3 -C 8 cycloalkyl; R 3 is selected from the group consisting of -H, -NHC(O)phenyl or -NHC(O)OC(CH 3 ) 3 , with the overall proviso that one of R 2 and R 3 is -H but R 2 and R 3 are not both -H; R 4 is -H or selected from the group consisting of -OH, -OAc (-OC(O)CH 3 ), -OC(O)OCH 2 C(Cl) 3 , -OCOCH 2 CH 2 NH 3 + HCOO, -NHC(O)phenyl, -NHC(O)OC(CH 3 ) 3 , -OCOCH 2 CH 2 COOH and pharmaceutically acceptable salts thereof, -CO(CH 2 ) 3 COOH and pharmaceutically acceptable salts thereof, and -OC(O)-Z-C(O)-R' [where Z is ethylene (-CH 2 CH 2 -), propylene (-CH 2 CH 2 CH 2 -), -CH-CH-, 1,2-cyclohexane or 1,2-ρhenylene, R' is -OH, -OH base, -NR' 2 R' 3 , -OR' 3 , -SR' 3 , -OCH 2 C(O)NR' 4 R'j where R' 2 is -H or -CH 3 , R' 3 is or (CH 2 ) n N + R'gR' 7 R'g X " where n is 1-3, R' 4 is -H or -C,-C 4 alkyl, R' 5 is -H, -C,-C 4 a__kyl, benzyl, hydroxyethyl, -CH 2 CO 2 H or dimethylaminoethyl, R' 6 and R' 7 are -CH 3 , -CH 2 CH 3 , benzyl or R' 6 and R' 7 together with the nitrogen of NR'gR' 7 form a pyrrolidino, piperidino, morpholino, or N-methylpiperizino group; R' 8 is -CH 3 , -CH 2 CH 3 or benzyl , X" is halide, and base is NH 3 , (HO H^N, N(CH 3 ) 3 , CH 3 N(C 2 H 4 ) 2 NH, NH 2 (CH 2 ) 6 NH 2 , N-methylglucamine, NaOH or KOH], -OC(O)(CH 2 ) n NR 2 R 3 [where n is 1-3, R 2 is -H or -C,-C 3 alkyl and R 3 -H or -C,-C 3 alkyl], -OC(O)CH(R")NH 2 [where R" is selected from the group consisting of -H, -CH 3 , -CH 2 CH(CH 3 ) 2 , -CH(CH 3 )CH 2 CH 3 , -CH(CH 3 ) 2 , -CH^henyl, -(CH 2 ) 4 NH 2 , -CH 2 CH 2 COOH, -(CH^NHC -NHJNHJ, the residue of the amino acid proline, -OC(O)CH«CH 2 , -C(O)CH 2 CH 2 C(O)NHCH 2 CH 2 SO 3 . Y + , -OC(O)CH 2 CH 2 C(O)NHCH 2 CH 2 CH 2 SO 3 -γ + wherein Y + is Na + or N + (Bu) 4 , -OC(O)CH 2 CH 2 C(O)OCH 2 CH 2 OH; Rj is -H or -OH, with the overall proviso that when R 5 is -OH, R 4 is -H and with the further proviso that when R 5 is -H, R 4 is other than -H; R 30 is -H, -OH or -OC(O)CH 3 ; and pharmaceutically acceptable salts thereof when the compound contains either an acidic or basic functional group. The compounds of Formula HI (or ma) include both the 7-α and 7-β configuration of the 7-halo substitution. Halo refers to -F, -Br, -Cl, -I, or N 3 . In compounds of Formula HI (or Ifla): X 7 is preferably -F, and R 3 and R 5 are preferably -H, and R, is preferably phenyl or phenyl substituted with halo. A preferred embodiment of the subject invention are compounds of Formula III (or Iϋa) where R, is preferably phenyl or phenyl substituted with halo, R 2 is -NHC(O)NHC(CH 3 ) 3 , R 3 and R j are -H, R 4 is -OH, and R 30 is -OH or -OCOCH 3 . Additional preferred embodiments of Formula HI (or Ilia) include: - A compound according to Formula HI (or Dla) wherein R 4 is -H and R 5 is -OH; - A compound according to Formula III (or (Ilia) wherein R 4 is other than -H and R 5 is -H; - A compound according to Formula HI (or Iϋa) wherein R 3 is -H, and R, is Ph or substituted phenyl; - A compound according to Formula III (or Iϋa) wherein X 7 is -F; - A compound according to Formula HI (or Ilia) wherein X 7 is -α-F; - A compound according to Formula HI (or ma) wherein X 7 is -F and R 4 is other than -H and - A compound according to Formula m (or Iϋa) wherein X 7 is -F, R 3 is -H, and R ] is Ph or substituted phenyl; - A compound according to Formula III selected from the group consisting of 7-deoxy-7-fluoro- Δ 1213 -iso-taxol and 2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-7-fluoro-Δ 12 - 13 -iso-taxol; and - A compound according to Formula HI, namely N-debenzoyl-N-(t-butyl)aminocarbonyl-7- deoxy-7-fluoro-Δ 12,13 -iso-taxol. An additional preferred embodiment of Formula IE are compounds selected from the group consisting of 7-deoxy-7α-fluoro-Δ I2,I3 -iso-taxol, 7-deoxy-7β-fluoro-Δ 12,13 -iso-taxol, 2'-[{(2,2,2-trichloroethyl)-oxy}carbonyl]-7-deoxy-7α-fluoro-Δ 12,13 -iso-taxol and 2'-[{(2,2,2- trichloroethyl)-oxy}carbonyl]-7-deoxy-7β-fluoro-Δ 12,I3 -iso-taxol. Another embodiment of the present invention are Δ 6,7 -Δ 12,13 -iso-taxol analogs of general Formula IV (or IVa) wherein: R, is selected from the group consisting of -CH 3 , -C 6 H 5 or phenyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, Cj-C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, hydroxy or nitro; R 2 is selected from the group consisting of -H, -NHC(O)H, -NHC(O)C r C 10 alkyl, - NHC(O)phenyl, -NHC(O)phenyl substituted with one, 2 or 3 C,-C 4 alkyl, C j -C, alkoxy, halo, C C 3 alkylthio, trifluoromethyl, Cj- dialkylamino, hydroxy or nitro, -NHC(O)C(CH 3 )-CHCH 3 , -NHC(O)OC(CH 3 ) 3 , -NH 2 , -NHSO 2 -4-methylphenyl, -NHQOXCH^COOH, -NHC(O)-4-(SO 3 H)phenyl, -OH, -NHC(O)-l-adamantyl, -NHC(O)O-3-tetrahydrofuranyl, -NHC(O)O-4-tetrahydropyranyl, -NHC(O)CH 2 C-(CH 3 ) 3 , -NHC(O)C(CH 3 ) 3 , -NHC(O)OC,-C 10 alkyl, -NHC(O)NHC r C 10 alkyl, -NHC(O)NHPh substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, or nitro or -NHC(O)C 3 -C 8 cycloalkyl; and R 3 , R 4 , R 5 and R 30 are as defined above. A preferred embodiment of the present invention are Δ 6,7 -Δ 12,13 -iso-taxol analogs of general Formula IV (or IVa) where R, is phenyl or phenyl substituted with halo, R 2 is - NHC(O)C 6 H j , R 3 and R 5 are -H, and R 30 is -OC(O)CH 3 . Another preferred embodiment of the subject invention is compounds of Formula IV (or IVa) where R, is preferably phenyl or phenyl substituted with halo, R 2 is -NHC(O)OC(CH 3 ) 3 , and R 3 and R s are -H, and R 30 is -OH. Another preferred embodiment of the subject invention are compounds of Formula IV (or IVa) where R j is preferably phenyl or phenyl substituted with halo, R 2 is - NHC(O)NHC(CH 3 ) 3 , R 3 and R 5 are -H, R 4 is -OH, and R 30 is -OH or -OCOCH 3 . Preferred embodiments of Formula IV include: - A compound according to Formula IV, namely 7-deoxy-Δ 6,7 -Δ 12,I3 -iso-taxol; - A compound according to Formula IV, namely 2'-[{(2,2,2-trichloroethyl)oxy>carbonyl]-7- deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; and - A compound according to Formula IV, namely 10-acetyl-7-deoxy-Δ 6 ' 7 -Δ 12,13 -iso-taxotere; and - A compound according to Formula IV, namely N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy- Δ 6 - 7 -Δ 12 - 13 -iso-taxol. A preferred embodiment of the subject invention is compounds of Formula V (or Va) where R, is phenyl or phenyl substituted with halo, R 2 is -NHC(O)C 6 H 5 , R 3 and R 5 are -H, and R 30 is -C(O)CH 3 . Another preferred embodiment of the subject invention is compounds of Formula V (or Va) where R, is preferably phenyl or phenyl substituted with halo, R 2 is -NHC(O)OC(CH 3 ) 3 , and R 3 , Rj and R^ are -H. A further preferred embodiment of the subject invention is compounds of Formula ϋ where R ] is preferably phenyl or phenyl substituted with halo, R^ is -NHC(O)OC(CH 3 ) 3 , and R 3 and R 5 are -H, and R 30 is -C(O)CH 3 . Another preferred embodiment of the subject invention is compounds of Formula I where R, is preferably phenyl or phenyl substituted with halo, R 2 is -NHC(O)NHC(CH 3 ) 3 , R 3 and R 5 are -H, R 4 is -OH, and R 30 is -OH or -OCOCH 3 . A further embodiment of the present invention are iso-taxol analogs of general Formula V (or Va) wherein: R, is selected from the group consisting of -CH 3 , -C 6 H 5 or phenyl substituted with one, 2 or 3 Ci-C 4 alkyl, C r C 3 alkoxy, halo, C,-C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, hydroxy or nitro; R 2 is selected from the group consisting of -H, -NHC(O)phenyl, -NHC(O)phenyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, - alkylthio, trifluoromethyl, - C 6 dialkylamino, hydroxy or nitro, -NHC(O)C(CH 3 )-CHCH 3 , -NHC(O)OC(CH 3 ) 3 , -NH 2 , -NHSO 2 -4-methylρhenyl, -NHC(O)(CH 2 ) 3 COOH, -NHC(O)-4-(SO 3 H)phenyl, -OH, -NHC(O)-l-adamantyl, -NHC(O)O-3-tetrahydrofuranyl, -NHC(O)O-4-tetrahydropyranyl, -NHC(O)CH 2 C(CH 3 ) 3 , -NHC(O)C(CH 3 ) 3 , -NHC(O)OC,-C 10 alkyl, -NHC^NHC C^alkyl, -NHC(O)NHPh substituted with one, 2 or 3 C,-C 4 alkyl, C,-C 3 alkoxy, halo, C,-C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, or nitro, -NHC(O)C 3 -C 8 cycloalkyl; and R 3 , R 4 , R j and R 30 are as defined above. The compounds of Formula V (or Va) include both the 7-α and 7-β configuration of the 7-hydroxy substitution. An embodiment of the present invention are 7-deoxy-7-W-Δ 12,13 -iso-taxol analogs of general Formula VI (and Via) wherein: R x is selected from the group consisting of -CH 3 , -C 6 H 5 or phenyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, C,-C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, hydroxy or nitro; R 2 is selected from the group consisting of -H, -NHC(O)C r C, 0 alkyl (preferably -NHC(O)C 4 -C 6 alkyl), -NHC(O)ρhenyl, -NHC(O)phenyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, hydroxy or nitro, -NHC(O)C(CH 3 )-CHCH 3 , -NHC(O)OC(CH 3 ) 3 , -NH 2 , -NHSO 2 -4-methylphenyl, -NHC(O)(CH 2 ) 3 COOH, -NHC(O)-4-(SO 3 H)phenyl, -OH, -NHC(O)-l-adamantyl, -NHC(O)O-3-tetrahydrofuranyl, -NHC(O)O-4-tetrahydropyranyl, -NHC(O)CH 2 C(CH 3 ) 3 , -NHC(O)C(CH 3 ) 3 , -NHC(O)OC r C 10 alkyl, -NHC(O)NHC r C 10 alkyl, -NHC(O)NHPh substituted with one, 2 or 3 C,-C 4 alkyl, C r C 3 alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, or nitro, -NHC(O)C 3 -C 8 cycloalkyl; R 3 is selected from the group consisting of -H, -NHC(O)phenyl or -NHC(O)OC(CH 3 ) 3 ; with the overall proviso that one of R 2 and R 3 is -H but R 2 and R 3 are not both -H; R 4 is -H or selected from the group consisting of -OH, -OAc (-OC(O)CH 3 ), -OC(O)OCH 2 C(Cl) 3 , -OCOCH 2 CH 2 NH 3 + HCOO\ -NHC(O)phenyl, -NHC(O)OC(CH 3 ) 3 , -OCOCH 2 CH 2 COOH and pharmaceutically acceptable salts thereof, -OCO(CH 2 ) 3 COOH and pharmaceutically acceptable salts thereof, and -OC(O)-Z-C(O)-R' [where Z is ethylene (- CH 2 CH 2 -), propylene (-CH 2 CH 2 CH 2 -), -CH-CH-, 1,2-cyclohexane or 1,2-phenylene, R' is -OH, -OH base, -NR' 2 R' 3 , -OR' 3 , -SR' 3 , -OCH 2 C(O)NR' 4 R' 5 where R' 2 is -H or -CH 3 , R' 3 is - (CH 2 ) n NR' 6 R' 7 or (CH 2 ) n N + R'gR' 7 R , g X " where n is 1-3, R' 4 is -H or -C,-C 4 alkyl, R' 5 is -H, -C,-C 4 alkyl, benzyl, hydroxyethyl, -CH 2 CO 2 H or dimethylaminoethyl, R' 6 and R' 7 are -CH 3 , -CH 2 CH 3 , benzyl or R' 6 and R' 7 together with the nitrogen of NR'gR' 7 form a pyrrolidino, piperidino, morpholino, or N-methylpiperizino group; R' g is -CH 3 , -CH 2 CH 3 or benzyl , X" is halide, and base is NH 3 , (HO H 4 ) 3 N, N(CH 3 ) 3 , CH 3 N(C 2 H 4 ) 2 NH, NH 2 (CH 2 ) 6 NH 2 , N- methylglucamine, NaOH or KOH], -OC(O) (CH 2 ) n NR 2 R 3 [where n is 1-3, R 2 is -H or -C r C 3 alkyl and R 3 -H or -C r C 3 alkyl], -OC(O)CH(R")NH 2 [where R" is selected from the group consisting of -H, -CH 3 , -CH 2 CH (CH 3 ) 2 , -CH(CH 3 )CH 2 CH 3 , -CH(CH 3 ) 2 , -CH^henyl, -(CH 2 ) 4 NH 2 , -CH 2 CH 2 COOH, -(CH 2 ) 3 NHC(-NH)NHJ, the residue of the amino acid proline, -OC(O)CH-CH 2 , -C(O)CH 2 CH 2 C(O)NHCH 2 CH 2 SO 3 . Y + , -OC(O)CH 2 CH 2 C(O)NHCH 2 CH 2 CH 2 SO 3 Y + wherein Y + is Na + or N + (Bu) 4 , -OC(O)CH 2 CH 2 C(O)OCH 2 CH 2 OH; R j is -H or -OH, with the overall proviso that when R 5 is -OH, R 4 is -H and with the further proviso that when R 5 is -H, R 4 is other than -H; R 30 is -H, -OH or -OC(O)CH 3 ; and pharmaceutically acceptable salts thereof when the compound contains either an acidic or basic functional group. Another embodiment of the present invention are 7-deoxy-7-W-Δ 12,13 -iso-taxol analogs of general Formula VI (and Via) wherein: Rj is selected from the group consisting of -CH 3 , -C 6 H 5 or phenyl substituted with one, 2 or 3 C,-C 4 alkyl, C C 3 alkoxy, halo, C,-C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, hydroxy or nitro; R 2 is selected from the group consisting of -H, -NHC(O)C 1 -C 10 alkyl (preferably -NHC(O)C 4 -C 6 alkyl), -NHC(O)ρhenyl, -NHC(O)ρhenyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, hydroxy or nitro, -NHC(O)C(CH 3 )-CHCH 3 , -NHC(O)OC(CH 3 ) 3 , -NH 2 , -NHSO 2 -4-methylphenyl, -NHC(O)(CH 2 ) 3 COOH, -NHC(O)-4-(SO 3 H)phenyl, -OH, -NHC(O)-l-adamantyl, -NHC(O)O-3-tetrahydrofuranyl, -NHC(O)O-4-tetrahydropyranyl, -NHC(O)CH 2 C(CH 3 ) 3 , -NHC(O)C(CH 3 ) 3 , -NHC(O)OC,-C I0 alkyl, -NHC(O)NHC r C 10 alkyl, -NHC(O)NHPh substimted with one, 2 or 3 C r C 4 alkyl, C,-C 3 alkoxy, halo, C,-C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, or nitro, -NHC(O)C 3 -C 8 cycloalkyl; and W is selected from the group consisting of propionyl; O-(2,2-dichloroethyl)carbonate; O-(2-chloroethyl)carbonate; O-methyl; O-propyl; O-allyl; O-methoxymethyl; O-ethoxymethyl; O-methoxyethoxymethyl; O-benzyloxymethyl; O-(2,2,2-trichloroethoxy)methyl; O-(2,2,2-trichloroethoxy)methoxymethyl; and R 3 , R 4 , R j and R 30 are as defined above. A further preferred embodiment of the present invention are 7-deoxy-7-W-Δ 12,13 -iso-taxol analogs of general Formula VI wherein: R, is selected from the group consisting of -CH 3 , -C 6 H 5 or phenyl substituted with one, 2 or 3 C C 4 alkyl, C,-C 3 alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, hydroxy or nitro; R 2 is selected from the group consisting of -H, -NHC(O)C C I0 alkyl (preferably - NHC(O)C 4 -C 6 alkyl), -NHC(O)phenyl, -NHC(O)phenyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, C C 3 alkylthio, trifluoromethyl, - dialkylamino, hydroxy or nitro, -NHC(O)C(CH 3 )-CHCH 3 , -NHC(O)OC(CH 3 ) 3 , -NH 2 , -NHSO 2 -4-methylphenyl, -NHC(O)(CH 2 ) 3 COOH, -NHC(O)-4-(SO 3 H)phenyl, -OH, -NHC(O)-l-adamantyl, -NHC(O)O-3-tetrahydrofuranyl, -NHC(O)O-4-tetrahydropyranyl, -NHC(O)CH 2 C(CH 3 ) 3 , -NHC(O)C(CH 3 ) 3 , -NHC(O)OC r C 10 alkyl, -NHC(O)NHC r C 10 alkyl, -NHC(O)NHPh substituted with one, 2 or 3 C,-C 4 alkyl, C r C 3 alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, or nitro, -NHC(O)C 3 -C 8 cycloalkyl; W is selected from the group consisting of O-ethoxymethyl; O-methoxyethoxymethyl; O-benzyloxymethyl; O-(2,2,2-trichloroethoxy)methyl; O-(2,2,2-trichloroethoxy)methoxymethyl; and R 3 , R 4 , R j and R 30 are as defined above. A preferred embodiment of the subject invention is compounds of Formula VI where R, is phenyl or phenyl substituted with halo, R 2 is -NHC(O)C 6 H s , R 3 and R 5 are -H, and R 30 is - C(O)CH 3 . Another preferred embodiment of the subject invention is compounds of Formula VI where R, is preferably phenyl or phenyl substituted with halo, R 2 is -NHC(O)OC(CH 3 ) 3 , and R 3 , Rj and R 30 are -H. A further preferred embodiment of the subject invention is compounds of Formula VI where R, is preferably phenyl or phenyl substituted with halo, R 2 is - NHC(O)OC(CH 3 ) 3 , and R 3 and R 5 are -H, and R M is -OC(O)CH 3 . Another preferred embodiment of the subject invention is compounds of Formula VI where R, is preferably phenyl or phenyl substituted with halo, R 2 is -NHC(O)NHC(CH 3 ) 3 , R 3 and R 5 are -H, R 4 is -OH, and R 30 is -OH or -OCOCH 3 . In compounds of Formula VI, W is preferably selected from the group consisting of propionyl; O-(2,2-dichloroethyl)carbonate; O-(2-chloroethyl)carbonate; O-methyl; O-propyl; O-allyl; O-methoxymethyl; O-ethoxymethyl; O-methoxyethoxymethyl; O-benzyloxymethyl; 0-(2,2,2-trichloroethoxy)methyl; O-(2,2,2-trichloroethoxy)methoxymethyl; and more preferably O-methoxymethyl; O-ethoxymethyl; O-methoxyethoxymethyl; O-benzyloxymethyl; O-(2,2,2-trichloroethoxy)methyl; and O-(2,2,2-trichloroethoxy)methoxymethyl. Examples of -NHC(O)C r C I0 alkyl include -NHC(O)-n-pentyl and -NHC(O)CH(CH 3 )CH 2 CH 3 . Examples of Ci-Cg alkyl include straight and branched alkyl chains, including for example methyl, ethyl, isopropyl, t-butyl, isobutyl and 2-methyl-pentyl. Examples of C r C 3 alkoxy are methoxy, ethoxy, propoxy and isomeric forms thereof Halo refers to -F, -Br, -Cl or I, or N 3 . Examples of Formula II compounds of this invention include: 2'-[{(2,2,2-trichloroethyl)oxy>carbonyl]-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 7-deoxy-7β,8β-methano-Δ 12 I3 -iso-taxol; 2'-succinyl-7-deoxy-7β,8β-methano-Δ I2,13 -iso-taxol; 2'-(β-alanyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol formate; 2'-glutaryl-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2'-[-C(O)(CH 2 ) 3 C(O)NH(CH 2 ) 3 N(CH 3 ) 2 ]-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; 2'-(β-sulfopropionyl)-7-deoxy-7β,8β-methano-Δ 12 - I3 -iso-taxol; 2'-(2-sulfoethylamido)succinyl-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2'-(3-sulfopropylamido)succinyl-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2'-(triethylsayl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2'-(t-butyldimethylsilyl)-7-deoxy-7β,8β-methano-Δ 12 - 13 -iso-taxol; 2'-(N,N-diethylaminopropionyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2'-(N,N-dimethylglycyl)-7-deoxy-7β,8β-methano-Δ I2,13 -iso-taxol; 2'-(glycyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2'-(L-alanyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2'-(L-leucyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2'-(L-isoleucyl)-7-deoxy-7β,8β-methano-Δ 1 ,13 -iso-taxol; 2'-(L-valyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2'-(L-phenylalanyl)-7-deoxy-7β,8β-methano-Δ I2,13 -iso-taxol; 2'-(L-prolyl)-7-deoxy-7β,8β-methano-Δ I2 ' 13 -iso-taxol; 2'-(L-lysyl)-7-deoxy-7β,8β-methano-Δ I2,13 -iso-taxol; 2'-(L-glutamyl)-7-deoxy-7β,8β-methano-Δ I2,13 -iso-taxol; 2'-(L-arginyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 7-deoxy-7β,8β-methano-Δ I2 I3 -iso-taxotere; 10-acetyl-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxotere; N-debenzoyl-N-tetrahydrofuran-3-yloxycarbonyl-7-deoxy-7β,8β-methano-Δ 12,I3 -iso-taxol; N-debenzoyl-N-( 1 -adamantoyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-phenylaminocarbonyl-7-deoxy-7β,8β-methano-Δ I2,13 -iso-taxol; N-debenzoyl-N-t-butylaminocarbonyl-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-(l-methyl-l-cyclohexylanoyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-( 1 -phenyl- 1 -cyclopentanoyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-phthalimido-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-t-butylaminothiocarbonyl-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-t-amyloxycarbonyl-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-neopentyloxycarbonyl-7-deoxy-7β,8β-methano-Δ 12 ' I3 -iso-taxol; N-debenzoyl-N-(2-chloro-l,l-dimethylethyl)oxycarbonyl-7-deoxy-7β,8β-methano-Δ 12,13 - iso-taxol; N-debenzoyl-N-(3-methyl-3-pentyl)oxycarbonyl-7-deoxy-7β,8β-methano-Δ 12,I3 -iso-taxol; 3 '-desphenyl-3 '-(2-furyl)-7-deoxy-7β,8β-methano-Δ 12 13 -iso-taxol; 3'-desphenyl-3'-(2-thienyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 3'-desphenyl-3'-(l-naphthyl)-7-deoxy-7β,8β-methano-Δ :2,13 -iso-taxol; 3'-desphenyl-3'-(2-naphthyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 3 '-desphenyl-3 '-(4-methoxyphenyl)-7-deoxy-7β,8β-methano-Δ 1213 -iso-taxol; 3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 3'-desphenyl-3'-(4-bromophenyl)-7-deoxy-7β,8β-methano-Δ I2,13 -iso-taxol; 3'-desphenyl-3'-(3,4-methylenedioxyphenyl)-7-deoxy-7β,8β-methano-Δ 1213 -iso-taxol; 3'-desphenyl-3'-(3,4-dimethoxyphenyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 3 '-desphenyl-3 '-(4-nitrophenyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-7-deoxy-7β,8β-methano-Δ 1213 -iso-taxol; N-debenzoyl-N-(4-methoxybenzoyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7β,8β- methano-Δ I2,13 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3 ' -desphenyl-3 ' -(4-chlorophenyl)-7-deoxy-7β,8 β- methano-Δ I2,13 -iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3 '-desphenyl-3 '-(4-fluorophenyl)-7-deoxy-7β,8β- methano-Δ 12,I3 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7β,8β- methano-Δ 12 13 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7β,8β- methano-Δ 12,I3 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3 '-desphenyl-3 '-(4-methoxyphenyl)-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-7β,8β- methano-Δ 12 I3 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-7β,8β- methano-Δ 1 ,13 -iso-taxol; N-debenzoyl-N-(4-methoxybenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7β,8β-methano-Δ I2,13 -iso-taxol; and pharmaceutically acceptable salts thereof when the compound contains either an acidic or basic functional group. Examples of Formula HI compounds of this invention include: 2'-[{(2,2,2-trichloroethyl)oxy)carbonyl]-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-succinyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(β-alanyl)-7-deoxy-7-fluoro-Δ I2,13 -iso-taxol formate; 2'-glutaryl-7-deoxy-7-fluoro-Δ I2,I3 -iso-taxol; 2'-[-C(O)(CH 2 ) 3 C(O)NH(CH 2 ) 3 N(CH 3 ) 2 ]-7-deoxy-7-fluoro-Δ 12 - I3 -iso-taxol; 2'-(β-sulfopropionyl)-7-deoxy-7-fluoro-Δ I2,13 -iso-taxol; 2 ' -(2-sulfoethylamido)succinyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(3-sulfopropylamido)succinyl-7-deoxy-7-fluoro-Δ 12 ' I3 -iso-taxol; 2'-(triethylsilyl)-7-deoxy-7-fluoro-Δ 12 13 -iso-taxol; 2'-(t-butyldimethylsilyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(N,N-diethylaminopropionyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(N,N-dimethylglycyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(glycyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(L-alanyl)-7-deoxy-7-fluoro-Δ 12 13 -iso-taxol; 2'-(L-leucyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(L-isoleucyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(L-valyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(L-phenylalanyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(L-prolyl)-7-deoxy-7-fluoro-Δ 12 13 -iso-taxol; 2'-(L-lysyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(L-glutamyl)-7-deoxy-7-fluoro-Δ 12 I3 -iso-taxol; 2'-(L-arginyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 7-deoxy-7-fluoro-Δ 12,13 -iso-taxotere; 10-acetyl-7-deoxy-7-fluoro-Δ 12 I3 -iso-taxotere; N-debenzoyl-N-tetrahydropyran-4-yloxycarbonyl-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-pivaloyl-7-deoxy-7-fluoro-Δ 12,I3 -iso-taxol; N-debenzoyl-N-n-hexylaminocarbonyl-7-deoxy-7-fluoro-Δ 12 13 -iso-taxol; N-debenzoyl-N-t-butylaminocarbonyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-(l-methyl-l-cyclohexylanoyl)-7-deoxy-7-fluoro-Δ I2,13 -iso-taxol; N-debenzoyl-N-(l-phenyl-l-cyclopentanoyl)-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-phthalimido-7-deoxy-7-fluoro-Δ 12,I3 -iso-taxol; N-debenzoyl-N-t-butylaminothiocarbonyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-t-amyloxycarbonyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-neopentyloxycarbonyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-(2-chloro-l,l-dimethylethyl)oxycarbonyl-7-deoxy-7-fluoro-Δ 12 ' 13 -iso- taxol; N-debenzoyl-N-(3-methyl-3-pentyl)oxycarbonyl-7-deoxy-7-fluoro-Δ I2,I3 -iso-taxol; 3 '-desphenyl-3 '-(2-fiιryl)-7-deoxy-7-fluoro-Δ I2,I3 -iso-taxol; 3 '-desphenyl-3 '-(2-thienyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 3 '-desphenyl-3 '-( 1 -naphthyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 3 '-desphenyl-3 '-(2-naphthyl)-7-deoxy-7-fluoro-Δ I2,13 -iso-taxol; 3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 3 '-desphenyl-3 '-(4-chlorophenyl)-7-deoxy-7-fluoro-Δ 12,I3 -iso-taxol; 3'-desphenyl-3'-(4-bromophenyl)-7-deoxy-7-fluoro-Δ 12,I3 -iso-taxol; 3'-desphenyl-3'-(3,4-methylenedioxyphenyl)-7-deoxy-7-fluόro-Δ 12,13 -iso-taxol; 3'-desphenyl-3'-(3,4-dimethoxyphenyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 3 '-desphenyl-3 '-(4-nitrophenyl)-7-deoxy-7-fluoro-Δ I2,13 -iso-taxol; 3 '-desphenyl-3 '-(4-fluorophenyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-7-deoxy-7-fluoro-Δ I2 ' 13 -iso-taxol; N-debenzoyl-N-(4-methoxybenzoyl)-7-deoxy-7-fluoro-Δ 12,I3 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7-fluoro- Δ 12 13 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7-fluoro- Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7-fluoro- Δ I2 I3 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3 '-desphenyl-3 '-(4-fluorophenyl)-7-deoxy-7-fluoro- Δ 12 13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7-fluoro- Δ 12,I3 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-7-fluoro- Δ 12 3 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3 ' -desphenyl-3 ' -(4-methoxyphenyl)-7-deoxy-7-fluoro- Δ 12 13 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7-fluoro- Δ 12a3 -iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3 ' -desphenyl-3 ' -(4-chlorophenyl)-7-deoxy-7-fluoro- Δ 12 I3 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7-fluoro- Δ I2,I3 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7-fluoro- Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7-fluoro- Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-7-fluoro- Δ 12 I3 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3 , -(4-methoxyphenyl)-7-deoxy-7-fluoro- Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3 ' -desphenyl-3 ' -(4-methoxyphenyl)-7-deoxy-7-fluoro- Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-methoxybenzoyl)-3 ' -desphenyl-3 ' -(4-methoxyphenyl)-7-deoxy-7- fluoro-Δ 1 ,I3 -iso-taxol; and pharmaceutically acceptable salts thereof when the compound contains either an acidic or basic functional group. Examples of Formula IV compounds of this invention include: 2'-{[(2,2,2-trichloroethyl)oxy]carbonyl}-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 7-deoxy-Δ 6,7 -Δ 12>13 -iso-taxol; N-desbenzoyl-N-benzyloxycarbonyl-2'-{[(2,2,2-trichloroethyl)oxy]carbonyl}-7-deoxy- Δ 67 -Δ 12>13 -iso-taxol; N-desbenzoyl-N-benzyloxycarbonyl-7-deoxy-Δ 6,7 -Δ I2,13 -iso-taxol; 2'-succinyl-7-deoxy-Δ 6 ' 7 -Δ 12,13 -iso-taxol; 2'-(β-alanyl)-7-deoxy-Δ 6,7 -Δ 12 I3 -iso-taxol formate; 2'-glutaryl-7-deoxy-Δ 6 - 7 -Δ ,2 13 -iso-taxol; 2'-[-C(O)(CH 2 ) 3 C(O)NH(CH 2 ) 3 N(CH 3 ) 2 ]-7-deoxy-Δ 6l7 -Δ 12 - 13 -iso-taxol; 2'-(β-sulfopropionyl)-7-deoxy-Δ 6,7 -Δ 12 13 -iso-taxol; 2'-(2-sulfoethylamido)succinyl-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 2'-(3-sulfopropylamido)succinyl-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 2'-(triethylsilyl)-7-deoxy-Δ 6ι7 -Δ 12,13 -iso-taxol; 2'-(t-butyldimethylsilyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 2'-(N,N-diethylaminopropionyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 2'-(N,N-dimethylglycyl)-7-deoxy-Δ 0,7 -Δ 12,13 -iso-taxol; 2*-(glycyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 2'-(L-alanyl)-7-deoxy-Δ 6,7 -Δ I2 - 13 -iso-taxol; 2'-(L-leucyl)-7-deoxy-Δ 6 ' 7 -Δ 12,I3 -iso-taxol; 2'-(L-isoleucyl)-7-deoxy-Δ 6,7 -Δ I2 ' I3 -iso-taxol; 2'-(L-valyl)-7-deoxy-Δ 6 ' 7 -Δ 12ll3 -iso-taxol; 2'-(L-phenylalanyl)-7-deoxy-Δ 6 ' 7 -Δ 12 ' 13 -iso-taxol; 2'-(L-prolyl)-7-deoxy-Δ 6 - 7 -Δ 12>I3 -iso-taxol; 2'-(L-lysyl)-7-deoxy-Δ ,7 -Δ 12 - 13 -iso-taxol; 2'-(L-glutamyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 2'-(L-arginyl)-7-deoxy-Δ 6 - 7 -Δ 12,13 -iso-taxol; 7-deoxy-Δ 6,7 -Δ 12,I3 -iso-taxotere; 10-acetyl-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxotere; N-debenzoyl-N-( 1 -methyl- 1 -cyclohexylanoyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; N-debenzoyl-N-( 1 -phenyl- 1 -cyclopentanoyl)-7-deoxy-Δ 6,7 -Δ I ,13 -iso-taxol; N-debenzoyl-N-phthalimido-7-deoxy-Δ 6,7 -Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-t-butylaminothiocarbonyl-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; N-debenzoyl-N-t-amyloxycarbonyl-7-deoxy-Δ 6,7 -Δ :2,I3 -iso-taxol; N-debenzoyl-N-neopentyloxycarbonyl-7-deoxy-Δ 6,7 -Δ 1 ,I3 -iso-taxol; N-debenzoyl-N-(2-chloro- 1 , 1 -dimethylethyl)oxycarbonyl-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; N-debenzoyl-N-(3-methyl-3-pentyl)oxycarbonyl-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 3 '-desphenyl-3 '-(2-furyl)-7-deoxy-Δ 6 ' 7 -Δ 12ll3 -iso-taxol; 3'-desphenyl-3'-(2-thienyl)-7-deoxy-Δ 6 ' 7 -Δ 12,13 -iso-taxol; 3 '-desphenyl-3 '-(1 -naphthyl)-7-deoxy-Δ ,7 -Δ 12 - 13 -iso-taxol; 3 '-desphenyl-3 '-(2-naphthyl)-7-deoxy-Δ 6 - 7 -Δ 12,13 -iso-taxol; 3 '-desphenyl-3 '-(4-methoxyphenyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 3 * -desphenyl-3 '-(4-chlorophenyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 3 '-desphenyl-3 '-(4-bromophenyl)-7-deoxy-Δ 6,7 -Δ I2,13 -iso-taxol; 3 '-desphenyl-3 '-(3,4-methylenedioxyphenyl)-7-deoxy-Δ 6,7 -Δ 12 ' I3 -iso-taxol; 3 '-desphenyl-3 '-(3,4-dimethoxyphenyl)-7-deoxy-Δ 6,7 -Δ 12 - 13 -iso-taxol; 3 '-desphenyl-3 '-(4-nitrophenyl)-7-deoxy-Δ 6,7 -Δ I2,I3 -iso-taxol; 3 '-desphenyl-3 '-(4-fluorophenyl)-7-deoxy-Δ 6,7 -Δ 12 - I3 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-7-deoxy-Δ 6,7 -Δ 12,I3 -iso-taxol; N-debenzoyl-N-(4-methoxybenzoyl)-7-deoxy-Δ 6,7 -Δ I2,13 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-Δ 6,7 -Δ 12,13 - iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-7-deoxy-Δ 6 ' 7 -Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-Δ 6,7 -Δ 12,13 - iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-Δ 6,7 -Δ 12,13 - iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-Δ 6,7 -Δ 12,13 - iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-Δ 6,7 -Δ 12,13 - iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-Δ 6,7 -Δ 12 ' 13 - iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3 ' -desphen l-3 ' -(4-methoxyphenyl)-7-deoxy-Δ 6 ' 7 - Δ 1213 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-Δ 6 ' 7 -Δ 12,13 - iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-Δ 6,7 -Δ 12,13 - iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3 , -(4-chlorophenyl)-7-deoxy-Δ 6 ' 7 -Δ 12,13 - iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-Δ 6,7 -Δ 12 ' 13 - iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-Δ 6,7 -Δ 12 13 - iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-Δ 6,7 -Δ 12 ' 13 - iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-Δ 6,7 -Δ 12 ' 13 - iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-Δ 6,7 -Δ 12,13 - iso-taxol; N-debenzoyl-N-(4-methoxybenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-Δ 6,7 - Δ 12,13 -iso-taxol; N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; and pharmaceutically acceptable salts thereof when the compound contains either an acidic or basic functional group. Examples of Formula V compounds of this invention include: 2 , -[{(2,2,2-trichloroethyl)oxy)carbonyl]-Δ 12,13 -iso-taxol; Δ 12 13 -iso-taxol; 2'-succinyl-Δ 12,13 -iso-taxol; 2'-(β-alanyl)-Δ 12,13 -iso-taxol formate; 2'-glutaryl-Δ I2,13 -iso-taxol; 2'-[-C(O)(CH 2 ) 3 C(O)NH(CH 2 ) 3 N(CH 3 ) 2 ]-Δ 12 - 13 -iso-taxol; 2'-(β-sulfopropionyl)-Δ 1 ,I3 -iso-taxol; 2'-(2-sulfoethylamido)succinyl-Δ 12,13 -iso-taxol; 2'-(3-sulfopropylamido)succinyl-Δ 12,13 -iso-taxol; 2'-(triethylsilyl)-Δ 12,13 -iso-taxol; 2'-(t-butyldimethylsilyl)-Δ 12,13 -iso-taxol; 2'-(N,N-diethylaminopropionyl)-Δ 12,13 -iso-taxol; 2'-(N,N-dimethylglycyl)-Δ 12 - I3 -iso-taxol; 2'-(glycyl)-Δ 12 - 13 -iso-taxol; 2'-(L-alanyl)-Δ 12,1 -iso-taxol; 2'-(L-leucyl)-Δ 12 - 13 -iso-taxol; 2'-(L-isoleucyl)-Δ 12,13 -iso-taxol; 2'-(L-valyl)-Δ 12 - 13 -iso-taxol; 2'-(L-phenylalanyl)-Δ 12,I3 -iso-taxol; 2'-(L-prolyl)-Δ 12 I3 -iso-taxol; 2'-(L-lysyl)-Δ 12,13 -iso-taxol; 2 , -(L-glutamyl)-Δ 12,13 -iso-taxol; 2'-(L-arginyl)-Δ 12 13 -iso-taxol; Δ 12,I3 -iso-taxotere; 10-acetyl-Δ 12,I3 -iso-taxotere; N-debenzoyl-N-tetrahydropyran-4-yloxycarbonyl-Δ 12,I3 -iso-taxol; N-debenzoyl-N-pivaloyl-Δ 12,13 -iso-taxol; N-debenzoyl-N-π-hexylaminocarbonyl-Δ 12,13 -iso-taxol; N-debenzoyl-N-( 1 -methyl- 1 -cyclohexylanoyl)-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-( 1 -phenyl- 1 -cyclopentanoyl)-Δ I ,13 -iso-taxol; N-debenzoyl-N-phthalimido-Δ 12,13 -iso-taxol; N-debenzoyl-N-t-butylaminothiocarbonyl-Δ 12,13 -iso-taxol; N-debenzoyl-N-t-amyloxycarbonyl-Δ I2,13 -iso-taxol; N-debenzoyl-N-neopentyloxycarbonyl-Δ 12,13 -iso-taxol; N-debenzoyl-N-(2-chloro-l,l-dimethylethyl)oxycarbonyl-Δ 12,13 -iso-taxol; N-debenzoyl-N-(3-methyl-3-pentyl)oxycarbonyl-Δ I2,I3 -iso-taxol; 3 '-desphenyl-3 '-(2-furyl)-Δ 12 - 13 -iso-taxol; 3 '-desphenyl-3 * -(2-thienyl)-Δ 12,13 -iso-taxol; 3'-desphenyl-3'-(l-naphthyl)-Δ 12,13 -iso-taxol; 3 '-desρhenyl-3 '-(2-naphthyl)-Δ I2,13 -iso-taxol; 3 ' -desphenyl-3 ' -(4-methoxyphenyl)-Δ 12,13 -iso-taxol; 3 '-desphenyl-3 '-(4-chlorophenyl)-Δ 12 ' 13 -iso-taxol; 3 '-desphenyl-3 '-(4-bromophenyl)-Δ I2 13 -iso-taxol; 3 '-desphenyl-3 '-(3,4-methylenedioxyphenyl)-Δ 12 13 -iso-taxol; 3 '-desphenyl-3 '-(3,4-dimethoxyphenyl)-Δ I2,13 -iso-taxol; 3 '-desphenyl-3 '-(4-nitrophenyl)-Δ 12,13 -iso-taxol; 3 '-desphenyl-3 '-(4-fluorophenyl)-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-Δ 12,I3 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-Δ 12,I3 -iso-taxol; N-debenzoyl-N-(4-methoxybenzoyl)-Δ 12,I3 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-Δ 12 ' I3 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-Δ 12,I3 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)^ 12,13 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-Δ I2,13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3 '-desphenyl-3 '-(4-methoxyphenyl)-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-Δ 1 ,13 -iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-Δ 12,I3 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-Δ I2,13 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-Δ I2,13 -iso-taxol; N-debenzoyl-N-(4-methoxybenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-Δ 12,13 -iso-taxol; N-debenzoyl-N-(t-butyl)aminocarbonyl-Δ 12,13 -iso-taxol; and pharmaceutically acceptable salts thereof when the compound contains either an acidic or basic functional group. Additional preferred embodiments of the invention include: 7-deoxy-7β,8β-methano-Δ 1 ,13 -iso-taxotere; N-de-(t-butyloxycarbonyl)-N-(t-butyl)aminocarbonyl- 7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxotere; 7-deoxy-7-fluoro-Δ I2,13 -iso-taxotere; N-de-(t- butyloxycarbonyl)-N-(t-butyl)aminocarbonyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxotere; 7-deoxy-Δ 6 ' 7 - Δ 12,13 -iso-taxotere; and N-de-(t-butyloxycarbonyl)-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 6,7 -Δ 12,13 - iso-taxotere. Examples of Formula Ila compounds of the invention include: 2-debenzoyl-2-(m-cyanobenzoyl)-7-deoxy-7β,8β-methano-Δ 12,I3 -iso-taxol; 2-debenzoyl-2-(m-cyanobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-7β,8β- methano-Δ 12 13 -iso-taxol; 2-debenzoyl-2-(m-cyanobenzoyl)-10-acetyl-7-deoxy-7β,8β-methano-Δ 1 ,13 -iso-taxotere; 2-debenzoyl-2-(m-cyanobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7β,8β- methano-Δ 1 ' 13 -iso-taxol; 2-debenzoyl-2-(m-methoxybenzoyl)-7-deoxy-7β,8β-methano-Δ 12,!3 -iso-taxol; 2-debenzoyl-2-(m-methoxybenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(m-methoxybenzoyl)-10-acetyl-7-deoxy-7β,8β-methano-Δ 12 ' I3 -iso-taxotere; 2-debenzoyl-2-(m-methoxybenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy- 7β,8β- methano-Δ 12,I3 -iso-taxol; 2-debenzoyl-2-(m-chlorobenzoyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(m-chlorobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy>carbonyl]-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(m-chlorobenzoyl)-10-acetyl-7-deoxy-7β,8β-methano-Δ 1 ,13 -iso-taxotere; 2-debenzoyl-2-(m-chlorobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7β,8β- methano-Δ 12,I3 -iso-taxol; 2-debenzoyl-2-(m-azidobenzoyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(m-azidobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy>carbonyl]-7-deoxy-7β,8β- methano-Δ 12 I3 -iso-taxol; 2-debenzoyl-2-(m-azidobenzoyl)-10-acetyl-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxotere; 2-debenzoyl-2-(m-azidobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-cyanobenzoyl)-7-deoxy-7β,8β-methano-Δ 12,I3 -iso-taxol; 2-debenzoyl-2-(p-cyanobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-cyanobenzoyl)-10-acetyl-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxotere; 2-debenzoyl-2-(p-cyanobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7β,8β- methano-Δ I2,13 -iso-taxol; 2-debenzoyl-2-(p-methoxybenzoyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-methoxybenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-7β,8β- methano-Δ 12,I3 -iso-taxol; 2-debenzoyl-2-(p-methoxybenzoyl)-10-acetyl-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxotere; 2-debenzoyl-2-(p-methoxybenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy- 7β,8β- methano-Δ 12 ' I3 -iso-taxol; 2-debenzoyl-2-(p-chlorobenzoyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-chlorobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-chlorobenzoyl)-10-acetyl-7-deoxy-7β,8β-methano-Δ 12,I3 -iso-taxotere; 2-debenzoyl-2-(p-chlorobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7β,8β- methano-Δ 12 ' 13 -iso-taxol; 2-debenzoyl-2-(p-azidobenzoyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-azidobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-azidobenzoyl)-10-acetyl-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxotere; and 2-debenzoyl-2-(p-azidobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7β,8β- methano-Δ 12 ' I3 -iso-taxol. Examples of Formula πia compounds of the invention include: 2-debenzoyl-2-(m-cyanobenzoyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(m-cyanobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy)carbonyl]-7-deoxy-7-fluoro- Δ I2 ' 13 -iso-taxol; -debenzoyl-2-(m-cyanobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7- fluoro- Δ 12 I3 -iso-taxol; -debenzoyl-2-(m-methoxybenzoyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; -debenzoyl-2-(m-methoxybenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy>carbonyl]-7-deoxy-7- fluoro-Δ 12,13 -iso-taxol; -debenzoyl-2-(m-methoxybenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7- fluoro- Δ 12,13 -iso-taxol; -debenzoyl-2-(m-chlorobenzoyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; -debenzoyl-2-(m-chlorobenzoyl)-2 , -[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-7-fluoro- Δ 12,13 -iso-taxol; -debenzoyl-2-(m-chlorobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7- fluoro- Δ 12,I3 -iso-taxol; -debenzoyl-2-(m-azidobenzoyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; -debenzoyl-2-(m-azidobenzoyl)-2 , -[{(2,2,2-trichloroethyl)oxy>carbonyl]-7-deoxy-7-fluoro- Δ 12 - 13 -iso-taxol; -debenzoyl-2-(m-azidobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7- fluoro- Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-cyanobenzoyl)-7-deoxy-7-fluoro-Δ 12,I3 -iso-taxol; 2-debenzoyl-2-(p-cyanobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-7-fluoro- Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-cyanobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7- fluoro- Δ 12,I3 -iso-taxol; 2-debenzoyl-2-(p-methoxybenzoyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-methoxybenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy>carbonyl]-7-deoxy-7- fluoro- Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-methoxybenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7- fluoro- Δ I2,13 -iso-taxol; 2-debenzoyl-2-(p-chlorobenzoyl)-7-deoxy-7-fluoro-Δ 12,I3 -iso-taxol; 2-debenzoyl-2-(p-chlorobenzoyl)-2 ' -[ {(2,2,2-trichloroethyl)oxy }carbonyl] -7-deoxy-7-fluoro- Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-chlorobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7- fluoro- Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-azidobenzoyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-azidobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy>carbonyl]-7-deoxy-7-fluoro- Δ 12 13 -iso-taxol; 2-debenzoyl-2-(p-azidobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7- fluoro- Δ 12,I3 -iso-taxol; 2-debenzoyl-2-(m-cyanobenzoyl)-10-acetyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxotere; 2-debenzoyl-2-(m-methoxybenzoyl)-10-acetyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxotere; 2-debenzoyl-2-(m-chlorobenzoyl)-10-acetyl-7-deoxy-7-fluoro-Δ 12,I3 -iso-taxotere; 2-debenzoyl-2-(p-chlorobenzoyl)-10-acetyl-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxotere; 2-debenzoyl-2-(p-cyanobenzoyl)-10-acetyl-7-deoxy-7-fluoro- 12,13 -iso-taxotere; 2-debenzoyl-2-(p-azidobenzoyl)-10-acetyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxotere; and 2-debenzoyl-2-(m-azidobenzoyl)-10-acetyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxotere. Examples of Formula IVa compounds of the invention include: 2-debenzoyl-2-(m-cyanobenzoyl)-7-deoxy-Δ 6,7 -Δ 12,I3 -iso-taxol; 2-debenzoyl-2-(m-cyanobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-Δ 6,7 - Δ 12,13 -iso-taxol; 2-debenzoyl-2-(m-cyanobenzoyl)-10-acetyl-7-deoxy-Δ 6,7 -Δ 12,I3 -iso-taxotere; 2-debenzoyl-2-(m-cyanobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 6,7 - Δ 12 ' 13 - iso-taxol; 2-debenzoyl-2-(m-methoxybenzoyl)-7-deoxy-Δ 6,7 -Δ I2,13 -iso-taxol; 2-debenzoyl-2-(m-methoxybenzoyl)-2' - [ {(2,2,2-trichloroethyl)oxy }carbonyl] -7-deoxy-Δ 6,7 - Δ 12,13 -iso-taxol; 2-debenzoyl-2-(m-methoxybenzoyl)-10-acetyl-7-deoxy-Δ 6 ' 7 -Δ 12 I3 -iso-taxotere; 2-debenzoyl-2-(m-methoxybenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 6,7 - Δ 12,13 -iso-taxol; 2-debenzoyl-2-(m-chlorobenzoyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 2-debenzoyl-2-(m-chlorobenzoyl)-2'-[<(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-Δ 6 ' 7 - Δ 12,13 -iso-taxol; 2-debenzoyl-2-(m-chlorobenzoyl)-10-acetyl-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxotere; 2-debenzoyl-2-(m-chlorobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 6,7 - Δ 12,13 -iso- taxol; 2-debenzoyl-2-(m-azidobenzoyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 2-debenzoyl-2-(m-azidobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy>carbonyl]-7-deoxy-Δ 6,7 - Δ 12,13 -iso- taxol; 2-debenzoyl-2-(m-azidobenzoyl)-10-acetyl-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxotere; 2-debenzoyl-2-(m-azidobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 6 ' 7 - Δ 12,13 - iso-taxol; 2-debenzoyl-2-(p-cyanobenzoyl)-7-deoxy-Δ 6,7 -Δ π,I3 -iso-taxol; 2-debenzoyl-2-(p-cyanobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-Δ 6 - 7 - Δ 12 13 - iso-taxol; 2-debenzoyl-2-(p-cyanobenzoyl)-10-acetyl-7-deoxy-Δ 6,7 -Δ I2,13 -iso-taxotere; 2-debenzoyl-2-φ-cyanobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 6,7 - Δ 12,13 - iso-taxol; 2-debenzoyl-2-(p-methoxybenzoyl)-7-deoxy-Δ 6 ' 7 -Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-methoxybenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-Δ 6 ' 7 - Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-methoxybenzoyl)-10-acetyl-7-deoxy-Δ 6,7 -Δ 1 ,13 -iso-taxotere; 2-debenzoyl-2-(p-me oxybenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 6,7 - Δ 12 ' 13 -iso-taxol; 2-debenzoyl-2-(p-chlorobenzoyl)-7-deoxy-Δ 6,7 -Δ 12 - 13 -iso-taxol; 2-debenzoyl-2-(p-chlorobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy>carbonyl]-7-deoxy-Δ 6,7 - Δ 12,13 -iso- taxol; 2-debenzoyl-2-(p-chlorobenzoyl)-10-acetyl-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxotere; 2-debenzoyl-2-(p-chlorobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 6,7 - Δ 12,13 - iso-taxol; 2-debenzoyl-2-(p-azidobenzoyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-azidobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-Δ 6,7 - Δ 12,13 - iso-taxol; 2-debenzoyl-2-(p-azidobenzoyl)-10-acetyl-7-deoxy-Δ 6,7 -Δ 12,I3 -iso-taxotere; and 2-debenzoyl-2-(p-azidobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 6,7 -Δ 12,13 - iso-taxol. Examples of Formula Va compounds of the invention include: 2-debenzoyl-2-(m-cyanobenzoyl)-7-deoxy-Δ 12,I3 -iso-taxol; 2-debenzoyl-2-(m-cyanobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-Δ 12 ' 13 -iso- taxol; 2-debenzoyl-2-(m-cyanobenzoyl)-10-acetyl-7-deoxy-Δ 12,13 -iso-taxotere; 2-debenzoyl-2-(m-cyanobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 12,13 - iso-taxol; 2-debenzoyl-2-(m-methoxybenzoyl)-7-deoxy-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(m-methoxybenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-Δ 12,13 - iso-taxol; 2-debenzoyl-2-(m-methoxybenzoyl)-10-acetyl-7-deoxy-Δ 12,13 -iso-taxotere; 2-debenzoyl-2-(m-methoxybenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy- Δ 12,13 - iso-taxol; 2-debenzoyl-2-(m-chlorobenzoyl)-7-deoxy-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(m-chlorobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-Δ 12 ' 13 - iso-taxol; 2-debenzoyl-2-(m-chlorobenzoyl)-10-acetyl-7-deoxy-Δ 12,13 -iso-taxotere; 2-debenzoyl-2-(m-chlorobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 12,13 - iso-taxol; 2-debenzoyl-2-(m-azidobenzoyl)-7-deoxy-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(m-azidobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-Δ 12,I3 -iso- taxol; 2-debenzoyl-2-(m-azidobenzoyl)-10-acetyl-7-deoxy-Δ 12,I3 -iso-taxotere; 2-debenzoyl-2-(m-azidobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 12,13 -iso- taxol; 2-debenzoyl-2-(p-cyanobenzoyl)-7-deoxy-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-cyanobenzoyl)-2'-[<(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-Δ 12,13 -iso- taxol; 2-debenzoyl-2-(p-cyanobenzoyl)-10-acetyl-7-deoxy-Δ 12,13 -iso-taxotere; 2-debenzoyl-2-(p-cyanobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 12,13 -iso- taxol; 2-debenzoyl-2-(p-methoxybenzoyl)-7-deoxy-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-methoxybenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-Δ 12,13 - iso-taxol; 2-debenzoyl-2-(p-methoxybenzoyl)-10-acetyl-7-deoxy-Δ 12,13 -iso-taxotere; 2-debenzoyl-2-(p-methoxybenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 12,13 - iso-taxol; 2-debenzoyl-2-(p-chlorobenzoyl)-7-deoxy-Δ 12,13 -iso-taxol; 2-debenzoyl-2-(p-chlorobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-Δ 12,13 -iso- taxol; 2-debenzoyl-2-(p-chlorobenzoyl)-10-acetyl-7-deoxy-Δ 12,13 -iso-taxotere; 2-debenzoyl-2-(p-cMorobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 12 ' 13 - iso-taxol; 2-debenzoyl-2-(p-azidobenzoyl)-7-deoxy-Δ 1 ,13 -iso-taxol; 2-debenzoyl-2-(p-azidobenzoyl)-2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-Δ 12 ' 13 -iso- taxol; 2-debenzoyl-2-(p-azidobenzoyl)- 10-acetyl-7-deoxy-Δ 12,13 -iso-taxotere; and 2-debenzoyl-2-(p-azidobenzoyl)-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ I2,13 -iso- taxol. The present invention also provides a process for preparing oxazolidines of Formula 5 in which R x is as defined above; R, is selected from Cj-C 6 alkyl; R n is phenyl substituted with -(O -Cjalkyl),. where n is 1 to 3; R 12 is selected from the group consisting of -C(O)H, -C(O)C r C 10 alkyl (preferably -C(O)C 4 -C 6 alkyl), -C(O)phenyl, -C(O)phenyl substituted with one, 2 or 3 C,-C 4 alkyl, C,-C 3 alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, hydroxy or nitro, -C(O)C(CH 3 )-CHCH 3 , -C(O)OC(CH 3 ) 3 , -C(O)OCH 2 phenyl, -SO 2 -4-methylphenyl, -C(O)(CH 2 ) 3 COOH, -C(O)-4-(SO 3 H)phenyl, -C(O)-l-adamantyl, -C(O)O-3-tetrahydrofuranyl, -C(O)O-4-tetrahydropyranyl, -C(O)CH 2 C(CH 3 ) 3 , -C(O)C(CH 3 ) 3 , -C(O)OC,-C 10 alkyl, -C(O)NHC,-C, 0 alkyl, -C(O)NHPh substituted with one, 2 or 3 C,-C 4 alkyl, C,-C 3 alkoxy, halo, C,-C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, or nitro, or -C(O)C 3 -C 8 cycloalkyl, -C(O)C(CH 2 CH 3 ) 2 CH 3 , -C(O)C(CH 3 ) 2 CH 2 Cl, -C(O)C(CH 3 ) 2 CH 2 CH 3 , -C(O)- 1 -phenyl- 1 -cyclopentyl, -C(O)- 1 -methyl- 1 -cyclohexyl, -C(S)NHC(CH 3 ) 3 , -C(O)NHCC(CH 3 ) 3 or -C(O)NHPh; which comprises reacting a hydroxy-amine of Formula 3 in which R, and R 3 are as defined above and R 2 is selected from the group consisting of -NHC(O)H,-NHC(O)C 1 -C 10 alkyl (preferably -NHC(O)C 4 -C 6 alkyl), -NHC(O)phenyl, -NHC(O)phenyl substituted with one, 2 or 3 C r C 4 alkyl, C r C 3 alkoxy, halo, C,-C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, hydroxy or nitro, -NHC(O)C(CH 3 )-CHCH 3 , -NHC(O)OC(CH 3 ) 3 , -NHC(O)OCHjphenyl, -NHSO 2 -4-methylphenyl, -NHC(O)(CH 2 ) 3 COOH, -NHC(O)-4-(SO 3 H)phenyl, -NHC(O)-l-adamantyl, -NHC(O)O-3-tetrahydrofuranyl, -NHC(O)O-4-tetrahydropyranyl, -NHC(O)CH 2 C(CH 3 ) 3 , -NHC(O)C(CH 3 ) 3 , -NHC(O)OC r C 10 alkyl, -NHC(O)NHC,-C 10 alkyl, -NHC(O)NHPh substituted with one, 2 or 3 C C 4 alkyl, C C 3 alkoxy, halo, C,-C 3 alkylthio, trifluoromethyl, -Cg dialkylamino, or nitro, or -NHC(O)C 3 -C 8 cycloalkyl, -NHC(O)C(CH 2 CH 3 ) 2 CH 3 , -NHC(O)C(CH 3 ) 2 CH 2 Cl, -NHC(O)C(CH 3 ) 2 CH 2 CH 3 , -NHC(O)-l -phenyl- 1-cyclo-pentyl, -NHC(O)-l -methyl- 1 -cyclohexyl, -NHC(S)NHC(CH 3 ) 3 , -NHC(O)NHCC(CH 3 ) 3 or -NHC(O)NHPh; with (1) an electron rich benzaldehyde of Formula 4A or (2) an electron rich acetal of Formula 4 where n is 1-3. In addition, the present invention provides a process of preparing which comprises reacting an oxazolidine free acid of Formula 7 with a baccatin compound of Formula 8 in the presence of a dehydrating agent. Wherein R 30 and R 34 , being the same or different, are selected from the group consisting of -OC(O)C,-C 6 alkyl, -OC(O)OC r C 6 alkyl, -OC(O)OCH 2 CX 3 where X is Halo, -OC(O)OCH 2 CH 2 SiR 20 (where R 20 is C r C 6 alkyl, or -OSi(R 16 ) 3 [where R 16 , being the same or different, is selected from C,-C 6 alkyl or cyclo(Cj-C 8 )alkyl]; and X 2 , R„ and R 12 are as defined above. The present invention also provides a process of preparing which comprises reacting an oxazolidine free acid of Formula 7 with a baccatin compound of Formula 8' in the presence of a dehydrating agent. Wherein R 30 and R 34 , being the same or different, are selected from the group consisting of -OC(O)C r C 6 alkyl, -OC(O)OC,-C 6 alkyl, -OC(O)OCH 2 CX 3 where X is Halo, -OC(O)OCH 2 CH 2 SiR 20 (where R 20 is C r C 6 alkyl or -OSi(R 16 ) 3 [where R 16 , being the same or different, is selected from C,-C 6 alkyl or cyclo(C 5 - C 8 )alkyl]; and X 2 , R π and R 12 are as defined above. A further embodiment of the subject invention are the novel compounds of Formula 8 where R 34 is selected from 2-(3-methylbutyl)dimethylsilyl-O-, (n-butyl) 3 silyl-O-, 2-(2-methylethyl)diethylsilyl-O-, cyclohexyldimethylsilyl-O-, cycloheptyldimethylsilyl-O-. A further embodiment of the subject invention are the novel compounds of Formula 8' where R 34 is selected from 2-(3-methylbutyl)dimethylsilyl-O-, (n-butyl) 3 silyl-O-, 2-(2-methylethyl)diethylsilyl-O-, cyclohexyldimethylsilyl-O-, cycloheptyldimethylsilyl-O-. The compounds of the present invention are prepared by the method(s) as shown in Charts 1 through 7 and 46. Generally the compounds of this invention are prepared from a protected baccatin analog with a free 13-hydroxyl such as compound iii of Charts 1 & 2 or compound xvii of Chart 7 by oxidation to give the 13 keto-baccatins v or xviii. The respective enones are then reduced with activated zinc or by electrolytic reduction, or by other metal reductions such as sodium or aluminum amalgam, chromium(H) salts or other reductions of the correct reducing potential. The resulting enols vi of Chart 3 and xix of Chart 7 are coupled to a protected side chain precursor by one of several methods. Most favorably the coupling of the enols vi or xix may be accomplished by the method described in PCT/US93/11827 (Case 4809.P CP); see page 24, line 14 as well as Preparation Nos. 8, 11, 13, 16, 22, 28 and 60. Thus, the enols vi or xix are condensed with a protected isoserinyl carboxylic acid such as vii in the presence of a dehydrating agent such as dicyclohexyl carbodiimide, or other carbodϋmide, carbonyl diimidazole, 2,2-dipyridyl carbonate, alkyl or aryl sulfonyl chloride or sulfonic anhydride or other dehydrating agent known in the art for the preparation of esters to give the protected taxol analog viii or xi. The enols vi or xix may be also condensed with a side chain precursor by methods described in the literature (see: Kingston, D. G. I. Pharmac. Ther., 1991, 52, 1-34; Commercon, A.; Bezard, D.; Bernard, F.; Bourzat, J. D. Tetrahedron Lett., 1992, 33, 5185; Georg, G. I.; Cheruvallath, Z. S.; Himes, R. H.; Mejillano, M. R. BioMed. Chem. Lett. 1992, 2, 295; Kingston, D. G. I.; Molinero, A. A.; Rimoldi, J. M. Prog. Chem. Org. Nat. Prod., 1993, 61, pp 1-206 ). The resultant protected taxol analog viii or xi may then be deprotected to taxol analogs such as ix and xii. More specifically, the compounds of this invention may be prepared as shown in Charts 1, 2 and 3. Thus, 10-deacetyl baccatin ul (i, Chauviere, G.; Guenard, D.; Picot, F.; Senihl, V.; Potier, P. C.R.. Acad. Sc. Paris, Serie II, 1981, 93, 501.) may be selectively protected at the 7- position, for example with a carbonate, ester or silyl protecting group to give a protected baccatin (ii). The 7 protected baccatin (ii) may then be protected at the 10 position with a carbonate or ester group to give iii. If the 10 protecting group is acetate then the compound iii is a 7 protected derivative of baccatin ul. The same 10 acetyl derivative is available as shown in Chart 2. Thus, a 10 protected baccatin, particularly where the 10 protecting group is acetyl, is baccatin HI (iv). Protection of iv in the same manner as protection of ii from Chart 1, gives compound iii, particularly where, R 10 is acetate. The 13-hydroxyl group of compound iii, may be oxidized to the give the ketone v. The oxidation may be accomplished with manganese dioxide in aprotic solvents such as methylene chloride, tetrahydrofuran, dioxane, chloroform, toluene, or alkanes such as hexane, pentane, or heptane. The reaction may be run at 0 °C to 60 °C, though most readily at room temperature. The oxidation may be carried out with other oxidizing agents, such as chromium trioxide in pyridine, pyridinium dichromate, pyridinium chlorochromate, potassium permanganate, tetrapropylammonium perruthenate, Dess-Martin periodinane, or other oxidant known in the art. As shown in Chart 3, the ketone v may be reduced to the enol vi. This reduction is readily accomplished with zinc metal activated by washing successively with 1 N hydrochloric acid, water, ethanol and ether. The reduction is carried out in acetic acid at 25 °C, and is over in 2 to 4 hours. The reaction may be run at 0°C for 24 to 48 hours or at up to 70 °C for 10 to 20 minutes. The reaction may also be run in aqueous acetic acid, methanol containing ammonium chloride, or in water miscible solvents such as tetrahydrofuran or dioxane containing acetic acid, formic acid, or other carboxylic acid, or aqueous acid such as hydrochloric, sodium bisulfate, or phosphoric acid. The reduction also may be carried out electrolytically in solvents such as methanol, pyridine, tetrahydrofuran, or dioxane with a carbon or platinum electrode and with the electrolytic potential set just high enough to carry out the reduction. The reduction may also be accomplished with other metals such as sodium or aluminum amalgam, or with chromium (II) salts. The enol vi is readily coupled with an oxazolidinecarboxylic acid vii in a solvent such as toluene, xylene, tetrahydrofuran, dioxane, or the like in the presence of a dehydrating agent such as dicyclohexylcarbodiimide, or other carbodiimide, carbonyl diimidazole, 2,2-dipyridyl carbonate, alkyl or aryl sulfonyl chloride or sulfonic anhydride or other dehydrating agent known in the art for the preparation of esters in the presence of a catalyst such as 4-dimethylaminopyridine or tri- n-butyl phosphine to give the protected enol ester viii. When the R 14 protecting group on position 7 has a different selectivity from R 10 and is removable by mild acid or by hydrogenolysis then the protected enol ester viii may be converted to the deprotected Δ 12,13 -isotaxol analog ix. For example if R 14 is a silyl group such as trimethyl or triethyl silyl and R 10 is acetate; then treatment of protected enol ester viii with mild acid such as 80 % acetic acid-water for 4 to 110 hours at 10 °C to 60 °C gives the Δ I2,13 -isotaxol analog ix. Alternatively, the deprotection may be accomplished with mild acid such as 0.1 N hydrochloric acid in methanol or ethanol, or with other acids such as trifluoroacetic, methanesulfonic or other acid in alcoholic and mixed alcoholic and aqueous solvents. If the protecting group R 14 is removable by hydrogenation, such as a benzyloxymethyl ether, then conversion of protected enol ester viii to the deprotected Δ 12,13 -isotaxol analog ix may be accomplished by hydrogenation in solvents such as methanol, ethanol, ethyl acetate, tetrahydrofuran, or the like in the presence of a hydrogenolysis catalyst such as palladium metal, palladium on carbon, Raney nickel, or the like. The compounds of this invention include Δ 12,13 -iso taxol analogs with modification on the 6,7-, 7-, and 7,8- positions as shown in Charts 4 through 7. Thus, selective deprotection of R 14 of structure viii gives the 7-hydroxy compound x. If R 14 in compound viii is for example trichloroethyl carbonate and R 10 is an ester or ether, then reduction with zinc in a mildly acid medium such as acetic acid-water, methanol, ethanol, or other alcoholic solvent acidified with hydrochloric acid or ammonium chloride gives the 7-hydroxy compound x. If R 14 in compound viii is for example a silyl ether such trimethyl or triethyl silyl and R 10 is an ester or ether or carbonate, then treatment with tetra-n-butyl ammonium fluoride or pyridine-hydrofluoride or triethyl ammonium hydrofluoride in solvents such as tetrahydrofuran, dioxane, or alcoholic solvents such as methanol or ethanol gives the 7-hydroxy compound x. Compound xi where R 6 and R 7 taken together are a double bond and R 8 is methyl , a protected 7-deoxy-Δ 6,7 -Δ 12,I3 -isotaxol analog, is most favorably prepared from x by conversion of the 7-hydroxyl group of compound x to the triflate followed by elimination. Thus, treatment of 7-hydroxy compound x with trifluoromethanesulfonic anhydride in methylene chloride, 1,2-dichloroethane, chloroform, or other suitable aprotic solvent, in the presence of a base such as pyridine, 2-methyl pyridine, 2,6-dimethyl pyridine or 2,4,6-trimethyl pyridine or other suitable base at a temperature of -20 °C to 60 °C for 10 minutes to 10 hours gives the trifluoromethanesulfonate of alcohol x. Treatment of this trifluoromethanesulfonate with l,8-diazabicyclo[5.4.0]undec-7-ene, l,5-diazabicyclo[4.3.0]non-5-ene or other strong amine base in tetrahydrofuran, dioxane, or other suitable aprotic solvent at 0 °C to 90 °C for 10 minutes to 10 hours gives the Δ 6 ' 7 -compound of structure xi. The elimination of the trifluoromethanesulfonate of compound x can also be accomplished with other strong bases such lithium, potassium, or sodium hexamethyl disilazane, lithium diethyl, or di-isopropyl amide, sodium or potassium t-butoxide or other strong base in a suitable solvent such as tetrahydrofuran, dioxane, t-butyl alcohol or the like at -80 °C to 90 °C for 10 minutes to 5 hours. Compound xi where R 6 is hydrogen and R 7 and R 8 taken together are 7β,8β-methano, a protected 7-deoxy-7β,8β-methano-Δ 12,13 -isotaxol analog, can also be prepared from the trifluoromethanesulfonate of alcohol x. Thus, treatment of trifluoromethanesulfonate of compound x with sodium azide, sodium chloride, sodium sulfate, potassium azide, potassium chloride, potassium sulfate or other salt, in aqueous tetrahydrofuran, aqueous dioxane, aqueous methanol, or aqueous ethanol, or other water and water miscible solvent combinations at 0 °C to 90 °C for 20 minutes to 48 hours. Alternatively, a triflate x may be treated with 10 to 500 fold weight excess of silica gel either by slow elution on chromatography or in a batch mode in a solvent such as toluene, THF, dioxane, methylene chloride, ethyl acetate, DMF, DMA, or other solvent for 1 hour to 200 hours at room temperature. Compound xi where R 6 is hydrogen and R 7 is fluoride and R 8 is methyl, a protected 7-deoxy-7-fluoro-Δ I2 ' 13 -isotaxol analog, is most favorably prepared from alcohol x by reaction with a reagent such as diethylaminosulfur trifluoride (DAST), dimethylaminosulfur trifluoride (methylDAST), bis(dimethylamino)sulfur difluoride, bis(diethylamino)sulfur difluoride, or (diethylamino)(dimethylamino)sulfur difluoride. The preferred method for this conversion is with DAST or methylDAST. The reaction with DAST or methylDAST is carried out in an aprotic solvent such as methylene chloride (CH 2 C1 2 ), chloroform (CHC1 3 ), fluorotrichloromethane (Freon 11 ® ), ethylene glycol dimethyl ether (glyme), 2-methoxyethyl ether (diglyme), pyridine, hydrocarbons such as pentane, hexane, or isooctane, tetrahydrofuran (THF), benzene, toluene, xylene. The preferred solvent is methylene chloride. The reaction may be performed in a range of temperature from -100°C to 100°C or above. Generally, the reaction is begun under conditions of low temperature, e.g., -78°C, and then is allowed to proceed at a higher temperature, e.g., 25°C. The reaction is quenched with water, the crude product is isolated by standard extraction methods, and is purified by standard chromatographic methods and/or by crystallization. Compound xi where R 6 and R 7 taken together are a double bond and R 8 is methyl , a protected 7-deoxy-Δ 6 ' 7 -Δ 12,I3 -isotaxol analog, may also be prepared by reaction of alcohol x with a reagent such as diethylaminosulfur trifluoride (DAST), dimethylaminosulfur trifluoride (methylDAST), bis(dimethylamino)sulfur difluoride, bis(diethylamino)sulfiιr difluoride, or (diethylamino)(dimethylamino)sulfur difluoride as described above. Compound xi where R 6 is hydrogen and R 7 and R 8 taken together are 7β,8β-methano, a protected 7-deoxy-7β,8β-methano-Δ 12,13 -isotaxol analog, may also be prepared by reaction of alcohol x with a reagent such as diethylaminosulfur trifluoride (DAST), dimethylaminosulfur trifluoride (methylDAST), bis(dimethylamino)sulfur difluoride, bis(diethylammo)sulfur difluoride, or (diethylamino)(dimethylamino)sulfur difluoride as described above. A protected Δ 12 I3 -isotaxol analog xi of Chart 4 may be converted to a Δ 12 13 -isotaxol analog xii by deprotection. Thus, reaction of oxazolidine xi with a mild acid in an aqueous or alcoholic solvent gives the 13-isoserinyl-Δ ,2,13 -baccatin m (Δ 12,13 -isotaxol analog ) xii. More specifically, treatment of oxazolidine xi with mild acid such as 80 % acetic acid-water for 4 to 110 hours at 10 °C to 60 °C gives the Δ I213 -isotaxol analog xii. Alternatively, the deprotection may be accomplished with mild acid such as 0.1 N hydrochloric acid in methanol or ethanol, or with other acids such as trifluoroacetic, methanesulfonic or other acid in alcoholic and mixed alcoholic and aqueous solvents. Also the oxazolidine of xi is removable by hydrogenation. Thus, hydrogenation of oxazolidine xi in solvents such as methanol, ethanol, ethyl acetate, tetrahydrofuran, or the like in the presence of a hydrogenolysis catalyst such as palladium metal, palladium on carbon, Raney nickel, or the like gives Δ 12,13 -isotaxol analog xii. Δ 12,13 -Isotaxol analogs xiii of Chart 5 where R 14 is a carbonate, carbamate, ether, ester or silyl ether may be prepared by selective cleavage of the oxazolidine of viii. Thus, as described above, reaction of oxazolidine viii with a mild acid in an aqueous or alcoholic solvent gives the 13-isoserinyl-Δ 12,13 -baccatin ul (Δ 12,13 -isotaxol analog ) xiii. More specifically, treatment of oxazolidine viii with mild acid such as 80 % acetic acid-water for 4 to 110 hours at 10 °C to 60 °C gives the Δ I2 13 -isotaxol analog xiii. Alternatively, the deprotection may be accomplished with mild acid such as 0.1 N hydrochloric acid in methanol or ethanol, or with other acids such as trifluoroacetic, methanesulfonic or other acid in alcoholic and mixed alcoholic and aqueous solvents. Also the oxazolidine of viii is removable by hydrogenation. Thus, hydrogenation of oxazolidine viii in solvents such as methanol, ethanol, ethyl acetate, tetrahydrofuran, or the like in the presence of a hydrogenolysis catalyst such as palladium metal, palladium on carbon, Raney nickel, or the like gives Δ 12 ' 13 -isotaxol analog xiii. The Δ 12 ' I3 -isotaxol analog xv with R 17 as an ester, carbonate, carbamate, or ether of Chart 6 may be made from an oxazolidinyl 7-hydroxy-Δ 12,13 -isotaxol x by conversion to 7-substituted oxazolidine xiv followed by cleavage of the oxazolidine ring. Oxazolidine xiv, as a 7-ester, may be produced from oxazolidinyl 7-hydroxy-Δ 12,13 -isotaxol x by esteriflcation with an acyl halide, acyl anhydride or carboxylic acid and a dehydrating agent as is known in the art. Oxazolidine xiv, as a 7-carbonate, may be produced from an oxazolidinyl 7-hydroxy-Δ 12,13 - isotaxol x by reaction with an alkoxy chloroformate or alkoxy carbonate anhydride as is known in the art. Oxazolidine xiv, as a 7-carbonate, may also be prepared from an oxazolidinyl 7-hydroxy-Δ 12,13 -isotaxol x by reaction with phosgene, diphosgene, triphosgene or p-nitrophenyl chloroformate followed by reaction of the intermediate chloroformate or p-nitrophenyl carbonate with an alcohol as is known in the art. Oxazolidine xiv, as a 7-carbamate, may be prepared from an oxazolidinyl 7-hydroxy-Δ 12,13 -isotaxol x by reaction with a alkyl or aryl isocyanate as is known in the art. Oxazolidine xiv, as a 7-carbamate, may also be prepared from a 7-hydroxy-Δ 12,I3 -isotaxol x by reaction of a carbonate as prepared above with an amine as is known in the art. Oxazolidine xiv, as a 7-carbamate, may also be prepared from a 7-hydroxy-Δ 12,13 -isotaxol x by reaction with phosgene, diphosgene, triphosgene or p-nitrophenyl chloroformate and reaction of the intermediate chloroformate or p-nitrophenyl carbonate with an amine as is known in the art. Oxazolidine xiv, as a 7-alkoxymethyl or aryloxymethyl ether, may be prepared from a 7-hydroxy-Δ 12,13 -isotaxol x by reaction with a chloromethyl alkyl or chloromethylaryl ether as is known in the art. Oxazolidine xiv, as a 7-alkyl or aryl ether may be prepared from a 7-hydroxy-Δ 12,13 -isotaxol x by reaction with a base such as sodium hydride, potassium hydride or lithium diethyl, or diisopropyl amide, sodium or potassium hexamethyldisilazane or other strong base in a solvent such as tetrahydrofuran, dioxane, dimethoxy ethane, or other such solvent at -78 °C to 60 °C in the presence of an alkyl halide such as methyl iodide, ethyl iodide, benzyl chloride, allyl chloride or bromide of the like for 10 minutes to 48 hours to give oxazolidine xiv as a 7-alkoxy or aryloxymethyl ether. Oxazolidine xiv, as a 7-alkyl or aryl ether may also be prepared from a 7-hydroxy-Δ 12,13 -isotaxol 10 by reaction with a diazo alkane or aryl diazo compound in the presence of a transition metal catalyst such as rhodium, ruthenium or palladium in an aprotic solvent such as THF, dioxane, or DMF at a temperature of -20 °C to 150 °C. A 7-substituted oxazolidine xiv, as a 7 ester, carbonate, carbamate, or ether of Chart 6 as prepared above may be deprotected to a Δ I2,13 -isotaxol analog xv by the deprotection procedures as described for the conversion of oxazolidine viii to Δ 12 ' 13 -isotaxol analog xiii of Chart 5. A baccatin HI analog xvi of Chart 7 may be converted to a baccatin ul analog of structure xvii where R 6 and R 7 when taken together are a double bond and R 8 is methyl, or where R 6 is hydrogen and R 7 and R 8 when taken together are 7β,8β-methano, or where R 6 is hydrogen, R 7 is fluoro and R 8 is methyl may be prepared as described above and shown in Chart 4 for the conversion of 7-hydroxy compound x to the respective 7-deoxy-Δ 6,7 -Δ 12,13 -isotaxol analog, 7- deoxy-7β,8β-methano-Δ I2,13 -isotaxol analog, or the 7-deoxy-fluoro-Δ 12 ' I3 -isotaxol analog xi. A 13-hydroxy baccatin analog xvii may be oxidized to the 13 keto baccatin analog xviii in the same manner as described above and shown in Chart 2 for the oxidation of a 13-hydroxy baccatin analog iii to a 13-keto-baccatin analog v. A 13-keto baccatin analog xviii may be reduced to a Δ 12,13 -iso-baccatin analog xix as described above and shown in Chart 3 for the reduction of a 13-keto baccatin analog v to a Δ 12,13 -isobaccatin analog vi. A Δ 12,13 -isobaccatin analog xix may be converted to a protected Δ 12,13 -isotaxol analog xi as described above and shown in Chart 3 for the conversion of a Δ 12,13 -isobaccatin analog vi to a protected Δ I ,13 -isotaxol analog viii. A protected Δ 1 ,13 -isotaxol analog xi of Chart 7 may be converted to a Δ 12,13 -isotaxol analog xii as described above and shown in Chart 4. The compounds of Formula I where X 2 is other than -H, can be prepared by the methods disclosed in J. Am. Chem. Soc. 1994, 116, 4097-98 and Bioorganic & Medical Chemistry Letters, Vol. 4, No. 3, 479-82, 1994; and Tetrahedron Lett. 1994, 35, 8931 which are incorporated herein by reference. Alternatively, the compounds of this invention (Formula I) which comprises reacting an oxazoline free acid of Formula 7' with a baccatin compound of Formula 8 in the presence of a dehydrating agent; wherein R^ and R 34 , being the same or different, are selected from the group consisting of -OC(0)C r C 6 alkyl, -OC(O)OCι-C 6 aIkyl, -OC(O)OCH 2 CX 3 where X is Halo, - OC(O)OCH 2 CH 2 SiR ω (where Rj„ is Cj-Cgβlkyl), or -OSi(R 16 ) 3 [where R 16 , being the same or different, is selected from C j -C 6 alkyl or cyclo(C 3 -C 8 )alkyI]; X 2 is selected from the group consisting of -H, -Cj- alkyl, -C ! -C 3 alkoxy, halo, - -C 3 alkylthio, -trifluoromethyl, -C 2 -C 6 dialkylamino, benzyloxymethyl, cyano, azide (N 3 ), or nitro; R j is selected from the group consisting of -CH 3 , -CgH 5 or phenyl substituted with one, 2 or 3 -Q, alkyl, -C, alkoxy, halo, Cj-C, alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, 2-furyl, 2-thienyl, 1-naphthyl, 2-naphthyl or 3,4-methylenedioxyphenyl; and R' π is selected from the group consisting of -C,-C 10 alkyl, -phenyl, -phenyl substituted with one, 2 or 3 C -C 4 alkyl, Cj-C 3 alkoxy, halo, C 1 -C 3 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, -1-adamantyl, -3-tetrahydrofuranyl, -4-tetrahydropyranyl, or -CH 2 C(CH 3 ) 3 . Another aspect of this invention is the process of preparing which comprises reacting an oxazoline free acid of Formula 7' with a baccatin compound of Formula 8' in the presence of a dehydrating agent; wherein R M and R M , being the same or different, are selected from the group consisting of -OC(O)C x -C 6 alkyl, -OC(O)OC,-C 6 alkyl, -OC(O)OCH 2 CX 3 where X is Halo, - OC(O)OCH 2 CH 2 SiR 2 o (where R JO is C,-C 6 alkyl), or -OSi(R 16 ) 3 [where R 16 , being the same or different, is selected from Cι-C 6 alkyl or cyclo(C 5 -C 8 )alkyl]; X 2 is selected from the group consisting of -H, -Cj-C alkyl, -Cι-C 3 alkoxy, halo, -C 1 -C 3 alkylthio, -trifluoromethyl, -C 2 -C 6 dialkylamino, benzyloxymethyl, cyano, azide (N 3 ), or nitro; R, is selected from the group consisting of -CH 3 , -CgH j or phenyl substituted with one, 2 or 3 Cj-C 4 alkyl, Cj-C 3 alkoxy, halo, C C 3 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, 2-furyl, 2-thienyl, 1- naphthyl, 2-naphthyl or 3,4-methylenedioxyphenyl; and R' n is selected from the group consisting of - -C^alkyl, -phenyl, -phenyl substituted with one, 2 or 3 Cj-C 4 alkyl, -C, alkoxy, halo, -C 3 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, -1-adamantyl, -3-tetrahydrofuranyl, -4-tetrahydropyranyI, or -CH 2 C(CH 3 ) 3 . General procedure for the coupling of oxazoline acid to silyl protected Baccatin HI followed by deprotection is provided: Part A: The oxazoline acid slurried in toluene is treated with 0.5 -1 equivalents of a dehydrating agent such as a carbodiimide and allowed to react. The resulting solution is then treated wiith a catalytic amount of dimethylaminopyridine or a similar catalyst and the protected baccatin m. When TLC shows the reaction to be complete. The slurry is filtered to remove the urea, poured into aqueous sodium bicarbonate solution and extracted with methyl t- butyl ether. Concentration and purification by chromatography affords the coupled ester. Part B: The ester from above is combined with methanol and treated with HC1. The solution is refluxed until TLC shows the reaction to be complete. The reaction mixture is quenched with sodium bicarbonate solution and stirred at rt to effect O to N acyl migration. Isolation with Ethyl acetate and chromatography affords taxol. Silylation of 10-DAB (79). 10-DAB (79) and pyridine are combined in a ratio of 3 L pyridine to 1 g 10-DAB and treated with 5 equivalents of the silyl chloride at room temperature. The solution is stirred at room temperature until HPLC indicates the reaction is complete. Upon completion of the reaction, the solution is poured into water and the product is isolated with a suitable solvent, usually ethyl acetate or methyl t-butyl ether. The organic layers are dried over magnesium sulfate and concentrated to afford the silyl derivative (80). Example 1 Preparation of 13-keto-7-TES-baccatin m (2) A 5 g (7.13 mM) quantity of 7-TES-baccatin m (1, Denis, J. N.; Greene, A. E. J. Am. Chem. Soc. 1988, 110, 5911) is dissolved in 75 mL of methylene chloride and the resultant solution is treated with 5 g (57.5 mM) of manganese dioxide. The mixture is stirred with a magnetic stirrer for 19 hr at which time TLC indicates no starting material left. The reaction is then filtered through celite and the filtrate concentrated under vacuum giving 13-keto-7-TES-baccatin m. TLC(silica gel GF): SM R, = 0.,24 product R - 0.50, in (1:2) ethyl acetate-hexane. Proton NMR(CDC1 3 ,TMS): δ 8.08(d, 2H), 7.47-7.63(m, 3H), 6.59(s, 1H), 5.70(d, 1H), 4.93(d, 1H), 4.48(m, 1H), 4.31(d, 1H), 4.12(d, 1H), 3.91(d, 1H), 2.95(d, 1H), 2.65(d, 1H), 2.55(m, 1H), 2.23(s, 3H), 2.19(s, 3H), 2.18(s, 3H), 1.88(m, 1H), 1.67(s, 3H), 1.28(s, 3H), 1.19(s, 3H), 0.92(m, 9H), 0.58(m, 6H). Carbon NMR(CDC1 3 ,TMS): δ 199.95, 198.07, 169.85, 168.64, 166.53, 152.75, 139.96, 133.67, 129.76, 128.46, 83.65, 80.25, 78.20, 75.89, 75.77, 72.59, 71.98, 59.16, 45.94, 43.15, 42.18, 36.90, 32.74, 21.44, 20.56, 17.94, 13.25, 9.30, 6.46, 4.96. Example 1A. 13-Keto-7-TES-baccatin m (2) A slurry of activated manganese (TV) oxide (14.7 g, Aldrich) in CH 2 C1 2 (80 mL) is treated with a solution of 7-TES-baccatin (7.14 g) in CH 2 C1 2 (320 mL) added from a dropping funnel over a 5 minute period. The reaction is stirred at room temperature for 4 hours. TLC (30% acetone/hexane and 50% EtOAc/hexane) indicates that the reaction is complete. The mixture is filtered to remove the solids and further rinsed with CH 2 C1 2 . The combined filtrates are evaporated to dryness and subjected to high vacuum to yield 13-Keto-7-TES-baccatin in as a white solid (6.81 g, 96% yield): Tic: Silica gel; 50% EtOAc/hexane; starting material Rf «= 0.41, ketone 2 Rf - 0.59. 'H NMR (CDC1 3 , TMS), δ 8.07 (m, 2H), 7.63 (m, 1H), 7.50 (m, 2H), 6.59 (s, 1H), 5.70 (d, J - 6.8 Hz, 1H), 4.93 (d, J - 9.5 Hz, 1H), 4.48 (m, 1H), 4.33 (d, J - 8.4, 1H), 4.12 (d, J •= 8.4 Hz, 1H), 3.92 (d, J - 6.7 Hz, 1H), 2.96 (d, J - 19.9 Hz, 1H), 2.66 (d, J - 20.0 Hz, 1H), 2.55 (m, 1H), 2.23 (s, 3H), 2.194 (s, 3H), 2.188 (s, 3H), 1.88 (m, 1H), 1.85 (s, 1H), 1.67 (s, 3H), 1.28 (s, 3H), 1.19 (s, 3H), 0.92 (t, J - 7.8 Hz, 9H), 0.59 (q, J -= 7.6 Hz, 6H). Example 2 Preparation of 7-TES-Δ I2 ' 13 -iso-baccatin m (3) Zinc dust (2.82 g, 43.1 mg-atom) is sequentially washed with dilute HC1, water (6x), methanol (6x) and ether (3x), decanting the liquid each time. The zinc is dried under vacuum. A solution of 13-keto-7-TES-baccatin m (2, 0.498 g, 0.71 mM) in acetic acid (4 mL) is treated with the activated zinc. The reaction is stirred under nitrogen at room temperature 4 hours. The reaction is diluted with ethyl acetate, filtered through diatomaceous earth. Evaporation of the filtrate followed by dilution with toluene and re-evaporation 7-TES-Δ 12 13 -iso-baccatin HI. Proton NMR (CDC1 3 , TMS): δ 0.53 (m, 6H); 0.89 (m, 9H); 1.11 (s, 3H); 1.14 (s, 3H); 1.61 (s, 3H); 1.82 (s, 3H); 1.87 (m, IH); 2.09 (d, IH, J-18.0 Hz); 2.18 (s, 3H); 2.33 (s, 3H); 2.30-2.58 (m, 2H); 2.74 (d, IH, J=18.0 Hz); 4.14 (d, IH, J=5.3 Hz); 4.25 (d, IH, J-8.4 Hz); 4.37 (m, IH); 4.39 (d, IH, J-8.4 Hz); 4.37 (s, IH); 4.93 (dd, IH); 5.48 (dd, IH); 5.91 (s, IH); 7.48 (m, 2H); 7.61 (m, IH); 8.08 (m, 2H). Carbon NMR (CDC1 3 , TMS): 5.36, 6.69, 9.08, 12.75, 18.75, 21.18, 23.14, 29.89, 32.43, 37.17, 38.59, 39.66. 56.52, 59.09, 73.05, 73.36, 75.56, 76.82, 80.92, 84.50, 102.44, 128.53, 129.03, 129.90, 133.57, 146.02, 166.57, 168.83, 170.82, 205.52. Elem. Anal. Calc'd for C 37 H J2 O„ Si^ 63.41% C, 7.48% H. Found: 63.31%C, 7.45% H. IR(Nujol): 981, 1112, 1241, 1281, 1375, 1454, 1687, 1716, 1725, 1741, 3402, 3508 cm Example 2A. 7-Triethylsilyl-12,13-wobaccatin m (3) A solution of 13-keto-7-TES-baccatin m (2) (7.90 g, 11.3 mmol) in degassed HOAc (80 mL, argon) is placed in a 250 mL three neck round bottom flask equipped with an air powered stirrer. The solution is purged with nitrogen and then activated zinc dust (82 g) added in one portion as a dry powder. The reaction is stirred vigorously. The starting material is consumed after two hours by tic evidence (50% EtOAc/hexane). The reaction is worked up by dilution with EtOAc (degassed with argon). The reaction mixture is filtered through Celite under a nitrogen atmosphere. The flask and filter cake are rinsed well with degassed EtOAc. The combined filtrates are evaporated at a reduced pressure. Degassed toluene is added to the residue and re-evaporated. The addition and evaporation of toluene is repeated until the HOAc is gone (two more times). The vacuum on the evaporator is released and replaced each time with nitrogen. A white solid is obtained which is placed under high vacuum (0.02 Torr) overnight to yield 7.57 g (96 %) of 7-Triethylsilyl-12,13-wσbaccatin m. 'H NMR (CDC1 3 ,TMS), δ 8.08 (d, 2H, J - 7.1 Hz), 7.61 (t, IH, J - 7.5, Hz), 7.49 (t, 2H, J = 7.5 Hz), 5.92 (s, IH), 5.49 (d, IH, J - 5.3 Hz), 4.93 (m, IH), 4.40 (d, IH, J - 8.1 Hz), 4.37 (m, IH), 4.26 (d, IH, J - 8.5 Hz), 4.14 (d, IH, J - 5.3 Hz), 2.75 (d, IH, J - 18.0 Hz), 2.54-2.46 (m, IH), 2.41 (m, IH), 2.33 (s, 3H), 2.17 (s, 3H), 2.07 (m, IH,), 1.89 (m, IH), 1.81 (s, 3H), 1.14 (s, 3H), 1.11 (s, 3H), 0.89 (m, 9H), 0.52 (m, 6H). Example 3 Preparation of 7-TES-Δ 12,I3 -iso-baccatin m-13-(4S,5R)-N-Boc-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (5) (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid (4a,b) is prepared from the side chain salt as follows. The (4S,5R)~N-Boc-2-(2,4-dimethoxyphenyl)-4- phenyl-5-oxazolidinecarboxylic acid potassium salt (1.5 mM) is suspended in ethyl acetate, and the solution washed twice with 5% aqueous sodium bisulfate, once with brine, dried and evaporated. The carboxylic acid is treated with methylene chloride (2 mL), 4-dimethylaminopyridine (48 mg), a solution of the 7-TES-Δ 12 ' 13 -iso-baccatin IH (3, 0.492 g, 0.702 mM) in toluene (5 mL) plus methylene chloride (8 mL), and 1,3-dicyclohexylcarbodiimide (0.316 g, 1.53 mM). The solution is stirred under an inert atmosphere 2.5 h. The reaction is diluted with ethyl acetate and washed with aqueous sodium bisulfate and aqueous bicarbonate plus brine. The layers are filtered and separated, and the organic layer dried and evaporated. The product is purified by silica gel chromatography in acetone-hexane mixtures. 7-TES-Δ 12,13 -iso-baccatin III-13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (5a,b) is obtained. Proton NMR (CDC1 3 , TMS): δ 0.54 (m); 0.89 (m); 1.05 (s); 1.57 (s); 1.87 (m); 2.15 (s); 2.16 (s); 2.19 (s); 2.50 (m); 3.82 (s); 3.86 (s); 3.89 (s); 4.35 (m); 4.88 (m); 5.30 (m); 5.50 (2d); 5.88 (s); 5.99 (s); 6.50 (m); 7.35-7.65 (m); 8.02 (m). Separation of 5a & 5b The reaction is carried out as above with 7-TES-Δ 12,J3 -iso-baccatin III (3, 0.5 g, 0.71 mM) and the crude product obtained after aqueous extraction is chromatographed over an E. Merck size B medium pressure chromatography column eluted with (20-80) acetone-n-hexane (300 mL), (25-75) acetone-n-hexane (300 mL), and (30-70) acetone-n-hexane (300 mL), collecting fractions of 15 mL. Fractions 24-28 are found by TLC to contain a 50-50 mixture of less and more polar isomers of 7-TES-Δ 12 ' 13 -iso-baccatin m-13-(4S,5R)-N-Boc-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (5a & 5b, 355 mg). Fractions 1-4, 15-23, and 29 are combined, evaporated and found to contain impure 5a and 5b. This mixture is rechromatographed over an E. Merck size B medium pressure chromatography column eluted with (25-75) ethyl acetate-n-hexane (200 mL), (30-70) ethyl acetate-n-hexane (500 mL), and (40-60) ethyl acetate-n-hexane (500 mL), collecting fractions of 15 mL. The less polar isomer of 7-TES-Δ 12,I3 -iso-baccatin ffl-13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4- phenyl-5-oxazolidinecarboxylic acid ester (5a) is found in fractions 25-30 and the more polar isomer of 7-TES-Δ 12,13 -iso-baccatin m-13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (5b) is found in fractions 31-39. Less polar isomer 7-TES-Δ 1 ,I3 -iso-baccatin m-13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4- phenyl-5-oxazolidinecarboxylic acid ester (5a): TLC (silica gel GF): (30-70) ethyl acetate-hexane; R f i 0.50. Proton NMR (CDC1 3 , TMS): δ 0.47-0.63 (q, 6H); 0.84-0.99 (t, 9H); 1.24 (s, 9H); 2.16 (s, 3H); 2.19 (s, 3H); 3.81 (s, 3H); 3.86 (s, 3H); 4.24-4.30 (d, IH); 4.35-4.42 (d, IH); 4.42-4.50 (q, IH); 4.83-4.93 (d, IH); 4.97 (s, IH); 5.35-5.50 (d, IH); 5.51-5.58 (d, IH); 6.00 (s, IH); 6.39-6.46 (dd, IH); 6.48-6.53 (d, IH); 6.72 (s, IH); 7.10-7.19 (d, IH); 7.29-7.65 (m, 8H); 8.00- 8.11 (d, 2H). More polar isomer 7-TES-Δ 12,13 -iso-baccatin m-13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4- phenyl-5-oxazolidinecarboxylic acid ester (5b): TLC (silica gel GF): (30-70) ethyl acetate-hexane; 1^: 0.37. Proton NMR (CDC1 3 , TMS): δ 0.45 -0.59 (q, 6H); 0.83-0.96 (t, 9H); 1.05 (s, 9H); 2.16 (s, 3H); 3.69-3.75 (d, IH); 3.82 (s, 3H); 3.90 (s, 3H); 4.18-4.25 (d, IH); 4.30-4.36 (d, IH); 4.27-4.43 (m, IH); 4.56-4.64 (bd, IH); 4.80-4.86 (d, IH); 5.25-5.33 (d, IH); 5.45-5.51 (d, IH); 5.88 (s, IH); 6.36-6.45 (dd, IH); 6.45-6.54 (d, IH); 7.30-7.68 (m, 9H); 8.00-8.06 (d, 2H). Example 4 Preparation of 7-TES-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin HI (6) 7-TES-Δ I2 - 13 -iso-baccatin m-13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (5a,b 355 mg 0.319mM) is stirred at room temperature and under nitrogen in 8 mL acetic acid-2 mL water. The reaction is followed by TLC and after 24 hours the more polar isomer 5b has all reacted while there some of the less polar isomer 5a still remains. The reaction is diluted with 100 mL ethyl acetate and washed with 50 mL IN sodium hydroxide and 3 times with 50 mL 5% sodium bicarbonate. The organic layer is dried over sodium sulfate and evaporated under vacuum. The crude product is chromatographed over an E. Merck size B prepacked silica gel column. Fractions of 10 mL are collected, analyzing them by TLC. The column is eluted with (20-80) acetone-n-hexane (800 mL), (30-70) acetone-n-hexane (300 mL), (40-60) acetone-n-hexane (300 mL). Fractions 22-36 are found to contain 7-TES-13-(N-Boc-β-phenyl isoserinyl)-Δ I ,13 -iso-baccatin HI (6) as a mixture. Fractions 59-63 are found to contain 13-(N-Boc-β-phenyl isoserinyl)-Δ 12,I3 -iso-baccatin m (7). The residue from evaporation of fractions 22-36 is rechromatographed over an E. Merck size B prepacked silica gel column eluted with (5-95) acetone-toluene. Fractions 30-60 are found to contain 7-TES-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin IH (6) TLC (silica gel GF): (10-90) acetone-toluene; R : 0.31 Proton NMR (CDC1 3 , TMS): δ 0.48-0.61 (q, 6H); 0.84-0.96 (t, 9H); 1.14 (s, 3H); 1.23 (s, 9H); .1.26 (s, 3H); 1.62 (s, 3H); 1.84-1.98 (t, IH); 2.03-2.15 (d, IH); 2.17 (s, 3H); 2.83-2.94 (d, IH); 3.18-3.25 (d, IH); 3.82-3.89 (d, IH); 4.26-4.34 (d, IH); 4.38-4.45 (d, IH); 4.36-4.48 (m, IH); 4.67-4.74 (d, IH); 4.89-4.97 (d, IH); 5.40 (s, IH); 5.53-5.57 (d, IH); 5.97 (s, IH); 7.13-7.63 (m, 9H); 8.08-8.17 (d, 2H). Mass spectrum: (M+H)+ measured at 964.4547; theory for CjjHggNOuSi+H is 964.4514. Example 5 Preparation of 13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin IH (7) 7-TES-Δ 12,13 -iso-baccatin m- 13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (5a,b; 0.69 g, 0.62 mM) is stirred in a mixture of acetic acid (16 L) and water (4 mL) at room temperature under an inert atmosphere 4 days. The reaction is diluted with ethyl acetate and washed multiple times with water and aqueous sodium bicarbonate. The organic layer is dried over anhydrous sodium sulfate and evaporated. The product is chromatographed on silica gel 60 (230-400 mesh) in acetone-hexane mixtures and 13-(N-Boc-β-phenyl isoserinyl)-Δ 1213 -isobaccatin HI is obtained. Proton NMR (CDC1 3 , TMS): δ 1.06 (s, 3H); 1.22 (s, 9H); 1.30 (s, 3H); 1.92 (m, IH); 2.08 (d, IH, J=19 Hz); 2.23 (s, 3H); 2.51 (m, IH); 2.57 (s, 3H); 2.76 (s, IH); 2.92 (d, IH, J-19 Hz); 3.21 (bs, IH); 3.52 (d, IH, J-4 Hz); 3.71 (d, IH, J-6 Hz); 4.33 (d, IH, J-8 Hz); 4.36 (m, IH); 4.42 (d, IH, J-8 Hz); 4.70 (d, IH); 4.94 (dd, IH); 5.40 (m, IH); 5.48 (s, IH); 5.58 (d, IH, J-6 Hz); 7.30-7.67 (m, 8H); 8.13 (d, 2H, J=7 Hz). Carbon NMR (CDC1 3 , TMS): 9.12, 14.38, 19.97, 21.07, 22.65, 28.13, 29.78, 32.73, 35.30, 38.78, 39.53. 55.72, 57.94, 71.54, 73.57, 73.71, 77.66, 77.77, 80.19, 81.05, 84.58, 121.90, 126.56, 128.04, 128.74,128.89, 128.95, 130.27, 133.67, 138.52, 143.33, 155.16, 166.77, 170.74, 170.90, 172.04, 206.64. Mass Spectrum (FAB): Calc'd for J H JJ N^ J : 850.3650 Found: 850.3650 Major ions at 794, 594, 105. Example 6 Preparation of 7-TES-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,I3 -iso-baccatin HI (6) and 13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin IH (7) Less polar isomer 7-TES-Δ 1213 -iso-baccatin m-13-(4S,5R)-N-Boc-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (5a, 50 mg, 0.045mM) is treated with 0.5 mL 0.1N HCI in MeOH with stirring at room temperature under nitrogen. The reaction is followed by TLC, starting material being found to be consumed in 30 minutes. The reaction mixture is partitioned between ethyl acetate-5% sodium bicarbonate. The organic layer is separated, dried over sodium acetate and evaporated under vacuum. The crude product is chromatographed over an E. Merck size A prepacked silica gel column, eluting with a gradient of (10-90) acetone-toluene to (20-80) acetone-toluene. Fractions of 5 mL are collected, analyzing them by TLC. Fractions 4-14 are found to contain 7-TES-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (6) and fractions 18-28 are found to contain 13-(N-Boc-β-phenyl isoserinyl)-Δ 12 ' I3 -iso-baccatin in (7). The data for 6 and 7 are comparable to those described in examples 4 and 5. Example 7 Preparation of 10-deacetyl-13-(N-Boc-β-phenyl isoserinyl)-Δ I2,13 -iso-baccatin ul (8). 13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin HI (7, 25mg 0.029mM) is stirred at room temperature under nitrogen in 1 mL 95% ethanol. To this is added 2 drops anhydrous hydrazine. Most of the starting material is reacted after 5 minutes, as indicated by TLC. After 1 hour, the reaction is partitioned between methylene chloride-water. The layers are separated and the water layer re-extracted with methylene chloride. The organic layers are combined, dried over sodium sulfate and evaprated under vacuum. The crude product is purified by chromatography over an E. Merck size A prepacked silica gel column. The column is eluted with (40-60) acetone-hexane, collecting 3mL fractions. The fractions are analyzed by TLC and pure product found in fractions 16-23, which are combined and evaporated, leaving 10-deacetyl-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin HI (8) as a solid. TLC (silica gel GF): 40-60 acetone-hexane; Rf: 0.28. Proton NMR (CDC1 3 , TMS): d 1.02 (s, 3H); 1.23 (s, 9H); 1.25 (s, 3H); 1.68 (s, 3H); 1.71 (s, 3H); 2.57 (s, 3H); 3.38 (bs, IH); 3.76-3.82 (d, IH); 4.16 (bs, IH); 4.27-4.33 (d, IH); 4.39-4.46 (d, IH); 4.50-4.56 (bd, IH); 4.56-4.63 (bd, IH); 4.70 (bs, IH); 4.90-4.97 (d, IH); 5.33-5.44 (bd, IH); 5.44-5.54 (bd, IH); 5.52-5.59 (d, IH); 7.30-7.45 (m, 5H); 7.45-7.56 (t, 2H); 7.56-7.66 (t, IH); 8.09-8.18 (d, 2H). Example 8 2'-Troc-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin m (9); A solution of 13-(N-Boc-β-phenyl isoserinyl)-Δ I2,I3 -iso-baccatin HI (7, 0.104 g, 0.12 mmole) and dry pyridine (0.6 mL) in methylene chloride (10 mL) is cooled to -20 °C under a nitrogen atmosphere. 2,2,2-Trichloroethyl chloroformate (20μL, 0.032 g, 0.015 mmole) is added in one portion to the solution. The reaction is examined after 1 hr by TLC, which shows that no reaction has occurred. Additional 2,2,2-trichloroethyl chloroformate (20 μL, 0.15 mmole) is added and the reaction stirred for an additional 1.75 hr. Although TLC indicate incomplete reaction (about 1:1 starting material and product) at this point, the reaction is quenched and worked up by washing with ice cold 0.1N HCI (2x), saturated NaHCO 3 , and with H 2 O. The organic layer is dried (NaSO^, filtered, and evaporated to give a residual mixture (0.139 g). The mixture is chromatographed over silica gel (one E. Merck size B Lobar column) using CH 2 C1 2 to apply the material to the column and 50% EtOAc-hexane to elute the column. Fractions of 8 mL volume are collected. Later fractions (42-60) contain starting material while earlier fractions (20-25) contained 2'-Troc-13-(N-Boc-β-phenyl isoserinyl)-Δ I2 ' 13 -iso-baccatin HI (9). Proton NMR (CDC1 3 , TMS): δ 8.13 (d, 2H, J = 7.3 Hz), 7.59 (t, IH, J = 7.3 Hz), 7.30- 7.52 (m, 7H), 5.66 (d, IH, J = 10.0 Hz), 5.58 (d, IH, J = 5.7 Hz, H 2 ), 5.45-5.53 (m, 3H), 4.96 (dd, IH, J - 3.2, 9.6 Hz, H 5 ), 4.71 (s, 2H, troc-CH 2 -), 4.42 (d, IH, J - 8.8 Hz, H 20a ), 4.39 (m, IH, H 7 ), 4.34 (d, IH, J - 8.6 Hz, H 20b ), 3.71 (d, IH, J = 5.7 Hz, H 3 ), 2.94 (d, IH, J - 19.0 Hz, H 14a ), 2.76 (s, IH, H n ), 2.61 (s, 3H, -CH 3 ), 2.53 (7 lines, IH, J m - 6.2, J - 9.5, J gem - 15.0 Hz, Hg a ), 2.23 (s, 3H, -CH 3 ), 2.17 (d, IH, J - 19.3 Hz, H 14b ), 1.93 (7 lines, IH, J H , - 11.3, J HJ - 3.3, J gem - 14.6 Hz, H 6b ), 1.67 (-CH 3 ), 1.64 (-CH 3 ), 1.28 (s, 3H, -CH 3 ), 1.22 (s, 9H, -CMe 3 ), 1.05 (s, 3H, -CH 3 ). Example 9 Preparation of Δ 12,13 -iso-baccatin m-13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4- phenyl-5-oxazolidinecarboxylic acid ester (10a) The less polar isomer of 7-TES-Δ 12,13 -iso-baccatin m-13-(4S,5R)-N-Boc-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (5a, 45 mg, 0.041mM) is dissolved in 1 mL dry THF with stirring at room temperature and under nitogen. To this is added tetrabutyl ammonium fluoride trihydrate (15 mg, 0.041 mM). The reaction is followed by TLC and is mostly complete in one hour. The reaction mixture is partitioned between ethyl acetate-5% sodium bicarbonate. The organic layer is dried over sodium sulfate and evaporated under vacuum. The crude product is purified by chromatography over an E. Merck size A prepacked silica gel column. The column is eluted with (40-60) ethyl acetate-hexane and (60- 40) ethyl acetate-hexane. Fractions of 5 mL are collected, analyzing them by TLC. The major product spot is found in fractions 12-18, which upon combining and evaporating under vacuum leaves Δ 12 ' I3 -iso-baccatin iπ-13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (10a) as a solid. TLC (silica gel GF): (40-60) ethyl acetate-hexane; R,: 0.44. Proton NMR (CDC1 3 , TMS): δ 1.07 (s, 3H); 1.25 (s, 9H); 1.33 (s, 3H); 1.62 (s, 3H); 1.70 (s, 3H); 2.17 (s, 3H); 2.24 (s, 3H); 3.51-3.56 (d, IH); 3.68-3.75 (d, IH); 3.82 (s, 3H); 3.88 (s, 3H); 4.28-4.36 (d, IH); 4.38-4.44 (d, IH); 4.36-4.47 (m, IH); 4.86-4.96 (dd, IH); 4.99 (s, IH); 5.33-5.41 (d, IH); 5.50 (s, IH); 5.56-5.63 (d, IH); 6.40-6.46 (dd, IH); 6.50-6.54 (d, IH); 6.72 (s, IH); 7.09-7.16 (d, IH); 7.33-7.68 (m, 8H); 8.01-8.10 (d, 2H). Mass spectrum: (M+H) + at 998. Other ions at 942, 898, 384, 284, 105, 57. Example 10 Preparation of 7-Troc-Δ 12 I3 -iso-baccatin m-13-(4S,5R)-N-Boc-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (11a) Δ 12,13 -Iso-baccatin m-13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (10a, 81 mg, 0.08 ImM) is stirred under nitrogen at room temperature in 1 mL dry pyridine. To this is added 140 μL trichloroethyl chloroformate in 200 μL methylene chloride. The reaction is left to go overnight. TLC the next day shows no starting material left. The reaction mixture is partitioned between methylene chloride- IN HCI. The layers are separated and the water layer re-extracted with methylene chloride. The organic layers are combined, dried over sodium sulfate and evaporated under vacuum. The crude product is chromatographed over an E. Merck size A prepacked silica gel column, eluting with (30-70) ethyl acetate-hexane. Fractions of 5 mL are collected, analyzing them by TLC. 7-Troc-Δ 1 ,13 -iso- baccatin IH-13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (11a) is found in fractions 9-15, which upon combining and evaporating under vacuum leaves a solid. TLC (silica gel GF): (30-70) ethyl acetate-hexane; R,: 0.14 Proton NMR (CDC1 3 , TMS): δ 1.10 (s, 3H); 1.26 (s, 9H); 1.32 (s, 3H); 1.77 (s, 3H); 2.16 (s, 3H); 2.19 (s, 3H); 3.82 (s, 3H); 3.86 (s, 3H); 3.92-3.98 (d, IH); 4.24-4.34 (d, IH); 4.36- 4.44 (d, IH); 4.54-4.63 (d, IH); 4.85-4.94 (d, IH); 4.85-4.94 (m, IH); 4.99 (bs, IH); 5.26-5.36 (m, IH); 5.36-5.44 (s, IH); 5.54-5.60 (d, IH); 5.63 (s, IH); 6.38-6.46 (dd, IH); 6.48-6.53 (dd, IH); a6.72 (s, IH); 7.10-7.18 (d, IH); 7.34-7.66 (m, 8H); 8.01-8.10 (d, 2H). Example 11 Preparation of 7-Troc-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,I3 -iso-baccatin UI (12) 7-Troc-Δ 12 13 -iso-baccatin ffl-13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-ρhenyl-5- oxazolidinecarboxylic acid ester (11a, 82 mg, 0.07mM) is treated at room temperature with stirring under nitrogen with 800 μL 0.1N HCI in methanol. The reaction is followed by TLC and is mostly complete after 1 hour. The reaction mixture is partitioned between ethyl acetate- 5% sodium bicarbonate. The layers are separated and the water layer re-extracted with ethyl acetate. The organic layers are combined, dried over sodium sulfate and evaporated under vacuum. The crude product is Chromatographed over an E. Merck size A prepacked silica gel column, eluting with a gradient of (30-70) ethyl acetate-hexane to (40-60) ethyl acetate-hexane. Fractions of 5 mL are collected, analyzing them by TLC. The product is found in fractions 11- 17 which upon combining and evaporating under vacuum give 7-Troc-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin HI (12) as a solid. TLC (silica gel GF): (30-70) ethyl acetate-hexane; R,: 0.14 Proton NMR (CDC1 3 , TMS): δ 1.08 (s, 3H); 1.25 (s, 9); 1.29 (s, 3H); 1.77 (s, 3H); 1.90-2.03 (t, IH); 2.14 (s, 3H); 2.59 (s, 3H); 3.30-3.36 (d, IH); 3.90-3.99 (d, IH); 4.26-4.33 (d, IH); 4.39-4.47 (d, IH); 4.54-4.63 (d, IH); 4.72 (bs, IH); 4.86-4.93 (d, IH); 4.90-4.98 (d, IH); 5.23-5.33 (q, IH); 5.34-5.51 (q, IH); 5.52-5.60 (d, IH); 5.62 (s, IH); 7.30-7.45 (m, 5H); 7.45- 7.55 (t, 2H); 7.55-7.65 (t, IH); 8.08-8.17 (d, IH). Example 12 2'-Troc-13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-7-fluoro-Δ 12 ' I3 -iso-baccatin HI (13), 2'-Troc-13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-7b,8b-methano-Δ 12 ' 13 -iso-baccatin HI (14), and 2'-Troc-13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-Δ 6 ' 7 -Δ 12 ' 13 -iso-baccatin III (15) Dimethylaminosulfur trifluoride (methylDAST, 8 μL, 0.011 g, 0.08 mmol) is added to a cold (-78 °C bath) solution of 2'-Troc-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin m (9, 0.050 g, 0.048 mmol) in CH 2 C1 2 (4 mL) under a N 2 atmosphere. The cooling bath is removed and after 1.75 hr, TLC indicats an incomplete reaction. The solution is again cooled to -78 °C and additional methylDAST (12 μL) is added. The cooling bath is removed and a TLC after 1.25 hr indicats complete reaction. The reaction is quenched with H 2 O and diluted with CH 2 C1 2 . The layers are separated and the organic layer washed with water. The aqueous layers are combined and back extracted with CH 2 C1 2 . The combined CH 2 C1 2 extracts are dried (Na 2 SO 4 ), filtered, and concentrated to give a white solid. This solid is chromatographed over silica gel (two E. Merck size A Lobar columns) using a solution in CH 2 C1 2 to apply the material to the column and using first 5% CH 3 CN-CH 2 C1 2 (115 fractions) and then 10% CH 3 CN-CH 2 C1 2 for elution of the column. Fractions of 3 mL volume are collected through fraction 100 and fractions of 8 mL volume are collected thereafter. Fractions 56-98 contained 2'-Troc-13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-baccatin HI (15); Proton NMR (CDC1 3 , TMS): δ 8.18 (d, 2H, J - 7.1 Hz), 7.60 (t, IH, J - 7.3 Hz), 7.50 (t, 2H, J ■= 7.5 Hz), 7.30-7.45 (m, 5H), 6.10 (dd, IH, J - 5.1, 9.9 Hz, Hg), 6.04 (d, IH, J -= 9.8 Hz, H 7 ), 5.73 (d, IH, J - 5.6 Hz, H 2 ), 5.66 (d, IH, J - 10.1 Hz), 5.50 (2H), 5.18 (s, IH, H 10 ), 5.14 (d, IH, J •= 5.0 Hz, H 5 ), 4.70 (s, 2H, troc-CH 2 -), 4.55 (d, IH, J - 8.3 Hz, H 20a ), 4.35 (d, IH, J - 8.3 Hz, Hja,), 3.68 (d, IH, J - 5.6 Hz, H 3 ), 2.97 (d , IH, J - 19.1 Hz, H 14a ), 2.75 (s, IH, H u ), 2.64 (s, 3H, -CH 3 ), 2.19 (s, 3H, -CH 3 ), 2.11 (d, IH, J - 19.3 Hz, H 14b ), 1.75 (s, 3H, -CH 3 ), 1.58 (s, -CH 3 ), 1.30 (s, 3H, -CH 3 ), 1.20 (s, 9H, -CMe 3 ), 1.04 (s, 3H, -CH 3 ); Fractions 106-124 contain a mixture of which 2'-Troc-13-(N-Boc-β-phenyl isoserinyl)-7- deoxy-7b,8b-methano-Δ I2,13 -iso-baccatin HI (14) was the major component. Proton NMR (CDC1 3 , TMS): δ 8.18 (d, 2H, J - 7.2 Hz), 7.58 (t, IH, J = 7.3 Hz), 7.49 (t, 2H, J - 7.4 Hz), 7.30-7.45 (m, 5H), 5.65 (m, 2H, H 2 , H 2 .), 5.48 (m, 2H, -NH-, H 3 .), 5.22 (d, IH, J ■= 2.0 Hz, H 10 ), 4.80 (d, IH, J = 3.2 Hz, H 5 ), 4.70 (s, 2H, troc-CH 2 -), 4.43 (d, IH, J - 8.7 Hz, H 2 , 4.11 (d, IH, J - 8.6 Hz, H 20b ), 3.87 (d, IH, J - 6.7 Hz, H 3 ), 2.96 (d, IH, J - 19.2 Hz, H 14a ), 2.75 (s, IH, H„), 2.58 (s, 3H, -CH 3 ), 2.46 (dt, IH, J - 4.4, 16.1 Hz, H , 2.17 (s, 3H, - CH 3 ), 2.15 (m, 3H, Hg b , H 19a , H 20b ), 1.68 (m, H 19b ), 1.63 (s, 3H, -CH 3 ), 1.31 (m, H 7 ), 1.31 (s, 3H, -CH 3 ), 1.13 (s, 9H, -CMe 3 ), 1.12 (s, 3H, -CH 3 ). Carbon NMR (CDC1 3 , TMS): δ 203.5, 169.7, 167.3, 164.8, 154.7, 153.2, 144.4, 137.1, 133.6, 130.3, 129.1, 129.0, 128.7, 128.3, 126.3, 123.1, 85.1, 80.4, 79.0, 78.6, 78.4, 77.2, 75.6, 55.0, 54.1, 39.7, 36.6, 32.9, 32.4, 30.2, 28.9, 28.0, 25.8, 22.4, 21.1, 20.8, 14.2, 12.8. The minor component in this mixture is compound 2'-Troc-13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-7-fluoro-Δ 12,I3 -iso-baccatin UI (13), which was identified in the following experiment after removal of the 2'-troc protecting group and separation from the 7β,8β-methano analog 13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-7b,8b-methano-Δ 12,13 -iso-baccatin HI (17, in Example 13). Example 13 13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-baccatin UI (16, and 13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-baccatin HI (17) A solution of the 1:9 mixture of 2'-Troc-13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-7- fluoro-Δ I2,13 -iso-baccatin m (13) and 2'-Troc-13-(N-Boc-β-phenyl ϊsoserinyl)-7-deoxy-7β,8β- methano-Δ 12,13 -iso-baccatin m (14) from the example 12 (0.029 g, 0.029 mmol) in CH 3 OH-HOAc (9:1) is stirred with activated Zn dust (0.074 g) under a N 2 atmosphere at room temperature. After 4 hr, a small amount of starting material remains; additional Zn dust (0.025 g) is added and stirring continued for another hour. The mixture is filtered to remove solids and the filtrate evaporated under reduced pressure giving a residue which is dissolved in CH 2 C1 2 and washed twice with H 2 O. The aqueous extracts are back extracted with CH 2 C1 2 and the combined organic extracts dried (Na 2 SO 4 ), filtered, and evaporated to yield a white solid residue (0.027 g). This residue is chromatographed over silica gel (two E. Merck size A Lobar columns, 3.5 mL fractions) by application to the column in CH 2 C1 2 solution and elution of the column with 40% EtOAc-hexane. Fractions 41-58 contain pure 13-(N-Boc-β-phenyl isoserinyl)- 7-deoxy-7β,8β-methano-Δ I2 I3 -iso-baccatin m (17), 66%); Proton NMR (CDC1 3 , TMS): δ 8.19 (d, 2H, J - 7.2 Hz), 7.29-7.62 (m, 8H), 5.62 (d, IH, 6.7 Hz, H 2 ), 5.41 (s, 2H, -NH-, H 3 .), 5.22 (d, IH, J - 2.0 Hz, H 10 ), 4.79 (d, IH, J - 3.1 Hz, H j ), 4.69 (d, IH, J - 3.8 Hz, H r ), 4.42 (d, IH, J - 8.7 Hz, H 2 , 4.09 (d, IH, J - 8.8 Hz, H , 3.87 (d, IH, J - 6.7 Hz, H 3 ), 2.96 (d, IH, J - 19.3 Hz, H, J, 2.75 (s, IH, H„), 2.56 (s, 3H, -CH 3 ), 2.45 (dt, IH, J - 4.3, 16.1 Hz, HJ 2.17 (s, -CH 3 ), 2.05-2.21 (m, 3H, Hg,, H 14b , H 19 ,), 1.72 (t, IH, J - 6.2 Hz, H 19b ), 1.58 (s, 3H, -CH 3 ), 1.33 (s, 3H, -CH 3 ), 1.13 (s, 12H, -CMe 3 , -CH 3 ). mass spectrum: found 832.3529, C 45 Hj 3 NO 14 + H requires 832.3544, 776, 732, 551, 73, 57 m/z. Fractions 62-75 contained 13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-7-fluoro-Δ 1 ,13 -iso-baccatin UI (16); Proton NMR (CDC1 3 , TMS): δ 8.13 (d, 2H, J - 7.2 Hz), 7.60 (t, IH), 7.49 (t, 2H), 7.30-7.42 (m, 5H), 5.87 (d, IH, J - 6.1 Hz, H 2 ), 5.54 (d, IH, J « 5.8 Hz, H 3 .), 5.41 (m, 2H, -NH-, H 10 ), 5.11 (d, IH, J - 7.2 Hz, H 5 ), 4.71 (m, IH, H r ), 4.58 (d, IH, J - 47 Hz, H 7 ), 4.49 (d, IH, J - 8.4 Hz, H 20a ), 4.36 (d, IH, J - 8.5 Hz, H 20b ), 4.11 (d, IH, J « 5.6 Hz, H 3 ), 2.92 (d, 1H, J - 19 Hz, H 14a ), 2.74 (s, IH, H„), 2.59 (s, 3H, -CH 3 ), 2.20 (s, 3H, -CH 3 ), 2.10 (d, IH, J = 19 Hz, H 14b ), 1.64 (s, 3H, -CH 3 ), 1.27 (s, 9H, -CMe 3 ), 1.08 (s, 3H, -CH 3 ). mass spectrum: found 852.3597, C 45 Hj 4 FNO 14 + H requires 852.3606, 832, 796, 752, 692, 180, 105, 57 m/z. Example 14 13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-baccatin HI (18) A solution of 2'-Troc-13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-Δ 6,7 -Δ 12 I3 -iso-baccatin m (15, 0.0080 g, 0.0079 mmol) in 9:1 CH 3 OH-HOAc (2 mL) is stirred with activated Zn dust (0.020 g) under N 2 at room temperature for 3 hr after which additional Zn dust (0.050 g) is added and stirring continued another 1.25 hr. The mixture is filtered to remove solids, the filtrate is evaporated, the residue is dissolved in CH 2 C1 2 and the solution washed with saturated aq NaHCO 3 and twice with H 2 O. The combined aqueous washes are back extracted with CH 2 C1 2 . The combined CH 2 C1 2 extracts are dried (Na^O^, filtered, and evaporated to give a white solid (0.008 g). The solid is chromatographed over silica gel (two E. Merck size A Lobar columns, 3 mL fractions) using a solution in CH 2 C1 2 for application to the column and 40% EtOAc-hexane for elution of the column. Pure 13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-Δ 6,7 - Δ 12,13 -iso-baccatin IH (18) is eluted in fractions 31-51. Proton NMR (CDC1 3 , TMS): δ 8.18 (d, 2H, J = 7.2 Hz), 7.61 (t, IH, J - 7.3 Hz), 7.50 (m, 2H), 7.30-7.44 (m, 5H), 6.09 (dd, IH, J - 5.1, 9.9 Hz, Hg), 6.05 (d, IH, J = 9.8 Hz, H 7 ), 5.73 (d, IH, J - 5.5 Hz, H 2 ), 5.40 (s, 2H, -NH-, H 3 .), 5.18 (s, IH, H 10 ), 5.13 (d, IH, J = 5.1 Hz, Hj), 4,70 (m, IH, H 2 .), 4.55 (d, IH, J - 8.3 Hz, H 20a ), 4.34 (d, IH, J - 8.4 Hz, H 20b ), 3.68 (d, IH, J - 5.4 Hz, H 3 ), 2.97 (d, IH, J - 18.9 Hz, H, J, 2.74 (s, IH, H π ), 2.61 (s, 3H, -CH 3 ), 2.20 (s, 3H, -CH 3 ), 2.09 (d, IH, J - 18.0 Hz, H 14b ), 1.75 (s, 3H, -CH 3 ), 1.52 (s, 3H, -CH 3 ), 1.32 (s, IH, -CH 3 ), 1.20 (s, 9H, -CMe,), 1.05 (s, 3H, -CH 3 ). mass spectrum: found 832.3579, C 4 jH 53 NO 14 + H requires 832.3544, 776, 732, 180, 105, 57 m/z. Example 15 Baccatin-III-7-O-triflate (20) A solution of baccatin-iπ (5.25 g, 8.93 mmoles) in CH 2 C1 2 (21 mL) and pyridine (18.1 mL) is cooled in a -30 °C bath. Trifluoromethanesulfonic anhydride (3.76 mL, 6.31 g, 22.3 mmoles) is added and the resulting mixture is stirred and allowed to warm to room temperature over a period of an hour. The reaction is complete after 4 hrs; saturated aq NH 4 C1 (50 mL) is added and the mixture is extracted with CH 2 C1 2 . The organic extract is washed successively with 1 M aq NaHSO 4 (50 mL), saturated aq NaHCO 3 (2 x 50 mL), saturated aq NaCl, and dried (Na 2 SO 4 ), filtered, and concentrated under reduced pressure. Care is taken not to warm the solution greater than 40 °C during removal of the solvent. A pale yellow solid is obtained which is flash chromatographed over silica gel (6" silica gel in a 75 mm column, 125 mL fractions). The material is applied to the column in a CH 2 C1 2 solution and the column eluted with 5% CH 3 CN-CH 2 C1 2 . Fractions 19-35 contain the desired 7-O-triflate (20) which is a solid. Proton NMR (CDC1 3 , TMS): δ 8.10 (d, 2H, J = 7.2 Hz), 7.63 (t, IH, J = 7.4 Hz), 7.49 (t, 2H, J - 7.6 Hz), 6.63 (s, IH, H 10 ), 5.68 (d, IH, J - 7.0 Hz, H 2 ), 5.52 (dd, IH, J ■= 7.5, 10.1 Hz, H 7 ), 4.94 (d, IH, J - 8.4 Hz, H 5 ), 4.86 (m, IH, H 13 ), 4.35 (d, IH, J « 8.4 Hz, H 20a ), 4.15 (d, IH, J - 8.4 Hz, H 20b ), 4.01 (d, IH, J - 7.0 Hz, H 3 ), 2.87 (5 lines, H, J, 2.30 (s, 3H, -CH 3 ), 2.20 (s, 3H, -CH 3 ), 2.10-2.30 (m, H 6a , Hg b , H 14b ), 1.87 (s, 3H, -CH 3 ), 1.59 (s, 3H, -CH 3 ), 1.19 (s, 3H, -CH 3 ), 1.05 (s, 3H, -CH 3 ). Example 16 Δ 6 - 7 -Baccatin-III (21) A solution of baccatin-πi-7-O-triflate (20, 0.97 g, 1.35 mmoles) and 1,8- diazabicyclo[5.4.0]undec-7-ene (1.01 mL, 1.03 g, 6.76 mmoles) in THF (6 L) is stirred at room temperature for 1 hr, at 50 °C for 2.5 hr, and at reflux temperature for 3 hr, after which reaction is complete. EtOAc is added and the solution washed with saturated aq NaHCO 3 and with saturated aq NaCl. The organic layer is dried (Na 2 SO 4 ), filtered, and evaporated under reduced pressure. The residue (0.876 g) is flash chromatographed over silica gel (6" silica gel in a 45 mm column) using a solution in CH 2 C1 2 (1 mL) for application to the column. The column is eluted with 10% CH 3 CN-CH 2 C1 2 (1 L), 15% CH 3 CN-CH 2 C1 2 (0.5 L), and with 20% CH 3 CN-CH 2 C1 2 (0.5 L). Fractions containing the desired material are detected by TLC and are combined to give Δ 6,7 -Baccatin-iπ (21). Proton NMR (CDC1 3 , TMS): δ 8.14 (d, 2H, J - 7.2 Hz), 7.63 (t, IH, J -= 7.3 Hz), 7.50 (t, 2H, J - 7.6 Hz), 6.24 (s , IH, H 10 ), 6.07 (dd, IH, J - 5.7, 9.9 Hz, Hg), 5.87 (d, IH, J - 9.9 Hz, H 7 ), 5.80 (d, IH, J - 6.6 Hz, H 2 ), 5.12 (d, IH, J - 5.5 Hz, H 5 ), 4.87 (m, IH, H I3 ), 4.43 (d, IH, J - 8.1 Hz, Hj , 4.29 (d, IH, J - 8.1 Hz, H 20b ), 4.10 (d, IH, J - 6.6 Hz, H 3 ), 2.31 (s, 3H, -CH 3 ), 2.20-2,31 (m, 2H, H 14fcb ), 2.24 (s, 3H, -CH 3 ), 1.97 (s, 3H, -CH 3 ), 1.85 (s, 3H, - CH 3 ), 1.12 (s, 6H, 2 -CH 3 ). Carbon NMR (CDC1 3 , TMS): δ 205.6, 170.3, 169.7, 167.0, 145.5, 139.8, 133.7, 132.6, 130.1, 129.4, 128.6, 126.2, 81.2, 81.0, 78.7, 76.4, 75.5, 67.9, 55.5, 42.7, 41.7, 39.0, 30.9, 26.3, 22.7, 21.0, 20.9, 20.2, 15.0. Example 17 Preparation of Δ 6,7 -13-keto-baccatin m (22) Δ 6,7 -Baccatin m (lOOmg, 0.17 mM) is dissolved in 2 mL CH 2 C1 2 and 300 mg activated MnO 2 added. TLC shows no starting material left after 18 hr at which point the reaction is filtered through Celite and concentrated in vacuo leaving Δ 6,7 -13 keto-baccatin m (22). Proton NMR (CDC1 3 , TMS): δ 1.19 (s,3H); 1.24 (s,3H); 1.81 (s,3H); 2.03 (s,3H); 2.19 (s,3H); 2.28 (s,3H); 2.67 (d,lH); 3.01 (d,lH); 4.22 (m,2H); 4.45 (d,lH); 5.09 (d.lH); 5.87 (m,2H); 6.09 (dd,lH); 6.32 (s.lH); 7.50 (m,2H); 7.64 (m,lH); 8.10 (d,2H) Mass Spectrum (FAB): Calc'd for C 31 H 3J O 10 : 567.2230; Found: 567.216 Example 18 Preparation of Δ 6,7 -Δ 12,13 -iso-baccatin m (23) Δ 6 ' 7 -13-keto-baccatinm (22, 90mg, 0.16 mM) is dissolved in 750 μL HOAc and 560 mg activated Zn is added. TLC shows no starting material after 1 hr at which point the reaction is filtered through Celite and concentrated in vacuo leaving Δ 6,7 -Δ 12,13 -iso-baccatin UI (23). Proton NMR (CDC1 3 , TMS): δ 1.02 (s,3H); 1.14 (s,3H); 1.56 (s,3H); 1.72 (s,3H); 2.18 (s,3H); 2.35 (s,3H); 3.83 (d,lH); 4.32 (d,lH); 4.52 (d,lH); 5.09 (s,lH); 5.14 (d,lH); 5.66 (d,lH); 6.05 (m,2H); 7.49 (m,2H); 7.62 (m,lH); 8.11 (d,2H) Mass Spectrum: [M+H] + - 569; C 31 H 37 O 10 requires 569, other ions at m/z 105 Example 19 Preparation of 7-deoxy-Δ ,7 -Δ 12 ' 13 -iso-baccatin m-13-(4S,5R)-N-Boc-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (24a,b) Crude (4S,5R)-N-Boc-2-(2,4 dimethoxyphenyl)-4-phenyl-5-oxazolidine carboxyUc acid potassium salt (116mg, 0.25mM) is partitioned between CH 2 C1 2 and 5% NaHSO 4 solution. The layers are separated and the aqueous layer extracted with EtOAc. The combined organic layers are filtered through anhydrous sodium sulfate and concentrated in vacuo leaving 112 mg of (4S,5R)-N-Boc-2-(2,4 dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid (4a,b). Δ 6,7 -Δ 12,13 -iso-baccatin III (23, 94mg, 0.16 mM) is dissolved in 1 mL toluene. All of the (4S,5R)-N-Boc-2-(2,4 dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid (4a,b) is added in a solution of CH 2 C1 2 . To the solution is added DCC (60mg, 0.29 mM) and DMAP (lOmg, 0.08mM). After stirring overnight the reaction is filtered through Celite. The filtrate is concentrated in vacuo and chromatographed over an E. Merck size A silica column in 10% EtOAc:Toluene. The column is eluted with 10% EtOAc:Toluene (25 mL), 15% EtOAc:Toluene (40 mL), 20% EtOAc:Toluene (100 mL), and 25% EtOAc.Toluene (50 mL) collecting 3 mL fractions. The less polar isomer 7-deoxy-Δ 6,7 -Δ 12,13 -iso-baccatin Iϋ-13-(4S,5R)-N-Boc-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (24a) is found in fractions 27-37. The more polar isomer 7-deoxy-Δ 6 ' 7 -Δ 12,13 -iso-baccatin m-13-(4S,5R)-N-Boc-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (24b) is found in fractions 44-54. Data for less polar isomer 7-deoxy-Δ 6,7 -Δ 12,13 -iso-baccatin EI-13-(4S,5R)-N-Boc-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (24a) Proton NMR (CDC1 3 , TMS): δ 1.00 (s,3H); 1.16 (s); 1.18 (s); 1.26 (s,3H); 1.66 (s,3H); 2.11 (s,3H); 2.13 (s,3H); 2.21 (m,lH); 2.77 (d,lH); 3.60 (d,lH); 3.73 (s,3H); 3.77 (s,3H); 4.25 (d,lH); 4.46 (d,lH); 4.90 (br s,lH); 5.05 (br s,lH); 5.11 (s,lH); 5.27 (br s,lH); 5.65 (d,lH); 5.99 (m,2H); 6.33 (dd,lH); 6.41 (d,lH); 6.65 (s,lH); 7.31 (m); 7.46 (m,3H); 7.56 (m,lH); 8.04 (d,2H) Data for more polar isomer 7-deoxy-Δ 6,7 -Δ 12,13 -iso-baccatin m-13-(4S,5R)-N-Boc-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxyUc acid ester (24b) Proton NMR (CDC1 3 , TMS): δ 1.04 (s); 1.27 (s); 1.69 (s,3H); 2.17 (s,3H); 2.67 (m,lH); 3.56 (d,lH); 3.80 (s,3H); 3.84 (m); 3.88 (s,3H); 4.26 (d,lH); 4.47 (d,lH); 4.59 (d,lH); 5.03 (d,lH); 5.08 (s,lH); 5.27 (d,lH); 5.67 (d,lH); 6.00 (m,2H); 6.48 (d,2H); 7.40 (br s); 7.50 (m,2H); 7.64 (m,lH); 8.06 (d,2H) Example 20 Preparation of 13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-baccatin IH (18) 7-deoxy-Δ 6 - 7 -Δ 12 - 13 -iso-baccatin HI-13-(4S,5R)-N-Boc-2-(2,4-d_methoxyphenyl)-4-phenyl- 5-oxazolidinecarboxylic acid ester (24b, 36mg, .037mM) is dissolved in 800 μL methanol and 200 uL acetic acid added. After stirring for 17 hrs. TLC shows the reaction is approximately 50% complete and no further change is seen after 20 hrs. Thus, another 400 μL methanol and 100 μL acetic acid is added. An additional 150 mL acetic acid is added after 41 hrs. After 48 hrs. the reaction is partitioned between 5% NaHCO 3 , brine, and EtOAc. The layers are separated and the aqueous re-extracted using EtOAc. The combined organic layers are filtered through Na 2 SO 4 and concentrated in vacuo. The residue is chromatographed over 4 gm of silica gel packed in 25% EtOAc:Toluene. The column was eluted with 20% EtOAc:Toluene (20 mL), 25% EtOAc:Toluene (40 mL), and 33% EtOAc:Toluene (24 mL) collecting 2 mL fractions. 13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-Δ 6 - 7 -Δ 12 ' 13 -iso-baccatin HI (18) is found in fractions 19-33. Mixed fractions 14-18 are rechromatographed over 1 gm of silica gel packed in 20% EtOAc:Toluene. The column was eluted with 20% EtOAc:Toluene (10 mL), 33% EtOAc:Toluene (6 mL), and 50% EtOAc:Toluene (6 mL) collecting 0.5 mL fractions. 13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-baccatin HI (18) is found if fractions 25-34. The physical data are consistent with those from example 14. Example 21 Preparation of N-(t-butylaminocarbonyl)-β-phenyl isoserine methyl ester (26) (2R,3S)-β-phenyl-isoserine methyl ester (4.35g, 22 mM) is dissolved in 100 mL dry THF and the flask cooled to 0 °C. To the solution is added t-butyl isocyanate (2.8 mL, 25 mM). TLC after 15 minutes shows some starting material left so another 0.5 mL of the isocyanate is added. TLC after lhour shows no starting material so the solvent is concentrated in vacuo. Proton NMR (CDC1 3 , TMS): δ 1.27 (s, 9H); 3.43 (d, IH); 3.81 (s, 3H); 4.34 (br s, 1H); 4.48 (m, IH); 5.27 (m, IH); 5.32 (m, IH); 7.29 (m, 2H); 7.34 (m, 3H) Mass spectrum (FAB-High Res.) Theory for CuH 22 N 2 O 4 +H: 295.1658 Found: 295.1663 Example 22 Preparation of (4S,5R)-N-(t-butylaminocarbonyl)2-(2,4-dimethoxyphenyl)-4-phenyl- 5-oxazolidinecarboxylic acid methyl ester (28a & b) N-t-butyl-β-phenyl-isoserine methyl ester (26, 68 mg, 0.23 mM) is dissolved in 5 mL dry THF and the solution treated with 2,4-dimethoxy benzaldehyde dimethyl acetal (70 mg, 0.33 mM) and pyridinium p-toluenesulfonate (6 mg, 0.02 mM) and the solution warmed to reflux. Approximately 2 mL solvent is boiled away 3 times in a 45 minute period replenishing with 2 mL of fresh THF at which time TLC shows no starting material. The solvent is concentrated in vacuo and chromatographed over 7 gm of silica gel packed in 1:3 EtOAc:Hexane. The column is eluted with 80 mL 1:3 EtOAc:Hexane, 45 mL 1:2 EtOAc:Hexane, 30 mL 2:3 EtOAc:Hexane, and 30 mL 1:1 EtOAc:Hexane collecting 3 mL fractions. A less polar isomer, (4S,5R)-N-(t-butylaminocarbonyl)2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid methyl ester (28a) was found in fractions 21-31. A more polar isomer, (4S,5R)-N-(t-butylaminocarbonyl)2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid methyl ester (28b) was found in fractions 33-42. Less Polar Product 28a Proton NMR (CDC1 3 , TMS): δ 1.19 (s, 9H); 3.82 (s, 3H); 3.85 (s, 3H); 3.89 (s, 3H); 4.68 (br s, IH); 4.88 (d, IH); 5.52 (d, IH); 6.46 (m); 6.70 (s, IH); 7.25-7.50 (m) Mass spectrum (FAB-High Res.): Theory for C^H^NA+H: 443.2182 Found: 443.2172 More Polar Product 28b Proton NMR (CDC1 3 , TMS): δ 0.99 (m, 9H); 3.53 (m, 3H); 3.81 (m, 3H); 3.88 (m, 3H); 4.05 (m, IH); 4.55 (m, IH); 5.45 (m, IH); 6.48 (m, 2H); 6.79 (m, IH); 7.25-7.50 (m) Mass spectrum (FAB-High Res.): Theory for C 24 H 3 ιN 2 O 6 +H: 443.2182 Found: 443.2180 Example 23 Preparation of (4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4- phenyl-5-oxazolidinecarboxylic acid potassium salt (29a) (4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid methyl ester (Example No. 22, 28a, 6.27 g, 14.2 mM) is stirred at room temperature under nitrogen in methanol (50 mL). To this is added a solution of potassium carbonate (2.50 g, 18.1 mM) in water (6 mL). After 6 hours the reaction is evaporated under reduced pressure to remove the methanol and the residue freeze dried. There is obtained a quantitative yield of (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid potassium salt (29a) admixed with potassium carbonate salts as a powder. Proton NMR (DMSO-dg, TMS): δ 1.10 (s, 9H); 3.77 (s, 3H); 4.17 (d, IH, J=2.3 Hz); 4.70 (bs, IH); 5.16 (d, IH, J=2.3 Hz); 6.50 (s+m, 2H); 6.60 (d, IH); 7.14-7.42 (m, 6H);. Example 23a Preparation of (4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4- phenyl-5-oxazolidinecarboxylic acid potassium salt (29b) (4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid methyl ester (Example No. 22, 28b, 0.98 g, 2.2 mM) is stirred at room temperature under nitrogen in methanol (50 mL). To this is added a solution of potassium carbonate (0.39 g, 2.5 mM) in water (1.1 mL). After 5 hours the reaction is evaporated under reduced pressure to remove the methanol and the residue freeze dried. There is obtained a quantitative yield of (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid potassium salt (29b) admixed with potassium carbonate salts as a powder. Proton NMR (DMSO-dg, TMS): δ 0.81 (s, 9H); 3.80 (s, 3H); 3.85 (s, 3H); 3.92 (d, IH, J=6.4 Hz); 4.86 (bs, IH); 5.16 (d, IH, J-6.4 Hz); 6.43 (s, IH); 6.56 (m, 2H); 7.30-7.47 (m, 6H);. Example 24 Preparation of (4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4- phenyl-5-oxazolidinecarboxylic acid (30a) (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazoUdinecarboxyUc acid potassium salt (29a, example 23) is partitioned between methylene chloride and water containing 0.9 mL IN HCI. The layers are separated and the aqueous layer reextracted with methylene chloride. The organic layers are combined, dried over sodium sulfate and evaporated. This leaves (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid (30a) as a solid. Example 25 Preparation of 7-TES-Δ 12,13 -iso-baccatin m-13-(4S,5R)-N-(t-butylaminocarbonyl)-2- (2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (31a) (4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid (3 mM, Preparation No. 24, 30a) is dissolved in 20 mL methylene chloride (11 mL)-toluene (5 mL). To this is added 7-TES-Δ 12,I3 -iso-baccatin m (1.0 g, 1.4 mM, 3, example 2), 4-dimethylaminopyridine (93 mg, 0.76 mM), and 1,3-dicyclohexylcarbodiimide (0.63 g, 3.1 mM) and the reaction mixture stirred for 3 h under a nitrogen atmosphere. The reaction is diluted with toluene and filtered. The filtrate is washed with 1 N hydrochloric acid, 5% aqueous sodium bicarbonate, and brine. The organic solution is dried over anhydrous sodium sulfate and evaporated. The product is purified by column chromatography on silica gel 60 in acetone-hexane mixtures. Concentration of the fractions found to contain product by TLC give 7-TES-Δ 12,13 -iso-baccatin IH-13-(4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)- 4-phenyl-5-oxazolidinecarboxylic acid ester (31a) as a solid. Proton NMR (CDC1 3 , TMS): δ 0.54 (m, 6H); 0.90 (m, 12H); 1.16 (s, 3H); 1.17 (s, 9H); 1.80 (s, 3H); 1.89 (m, IH); 2.15 (s, 3H); 2.18 (s, 3H); 2.30 (d, IH); 2.50 (m, 2H); 2.78 (d, IH); 3.83 (s, 3H); 3.85 (d, IH); 3.91 (s, 3H); 4.28 (d, IH); 4.38 (d, IH); 4.43 (m, IH); 4.64 (bs, IH); 4.88 (m, IH); 5.04 (d, IH); 5.55 (m, IH); 5.65 (d, IH); 5.99 (s, IH); 6.49 (m, 2H); 6.74 (s, IH); 7.22 (d, IH); 7.34-7.68 (m, 8H); 8.07 (m, 2H). Carbon NMR (CDC1 3 , TMS): δ 5.27, 6.55, 8.99, 13.83, 14.11, 18.92, 20.90, 22.30, 28.79, 29.67, 32.86, 36.94, 38.75, 39.63, 50.59, 55.13, 55.28, 56.42, 58.40, 62.81, 72.50, 73.15, 74.10, 76.88, 80.58, 84.28, 85.81, 98.11, 104.94, 117.48, 122.28, 126.75, 127.66, 128.41, 128.49, 128.76, 129.76, 133.43, 139.81, 142.87, 154.95, 158.14, 161.68, 166.32, 168.33, 168.55, 170.12, 204.76. Example 26 Preparation of 7-TES-13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-Δ I2,13 -iso- baccatin IH (32a) and 13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin HI (32b) 7-TES-Δ 12,13 -iso-baccatin HI-13-(4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (31a, example 25, 0.102 g, 0.092 mM) is stirred in a mixture of acetic acid (4 mL) and water (1 mL) at room temperature under an inert atmosphere 65 h. The reaction is diluted with ethyl acetate and washed with 5% aqueous sodium bicarbonate. The organic layer is dried over anhydrous sodium sulfate and evaporated. The product is purified by column chromatography on silica gel 60 in (30-70) and (40-60) acetone-hexane. Fractions of 4 mL are collected. Concentration of fractions 13-22 gives 7-TES-13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-Δ I2 ' 13 -iso-baccatin UI (32a). Concentration of fractions 35-40 gives 13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-Δ 12,13 - iso-baccatin IH (32b). Data for 32a Proton NMR (CDC1 3 , TMS): δ 0.53 (m, 6H); 0.89 (t, 9H); 1.13 (s, 12H); 1.24 (s, 4H); 1.57 (bs, IH); 1.62 (s, 3H); 1.68 (s, 3H); 1.89 (m, IH); 2.07 (d, IH); 2.16 (s, 3H); 2.50 (m, 2H); 2.58 (s, 3H); 2.86 (d, IH); 3.84 (d, IH, J=5.6 Hz); 4.34 (m, 4H); 4.71 (d, IH, J=2.9Hz); 4.92 (dd, IH); 5.03 (d, IH, J=9.0 Hz); 5.53 (m, 2H); 5.97 (s, IH); 7.28-7.68 (m, 8H); 8.11 (m, 2H). Data for 32b Proton NMR (CDC1 3 , TMS): δ 1.05 (s, 3H); 1.13 (s, 9H); 1.29 (s, 3H); 1.55 (s, 3H);1.62 (s, 3H); 1.65 (bs, IH); 1.89 (m, IH); 2.11 (d, IH); 2.23 (s, 3H); 2.47 (m, IH); 2.54 (s, 3H); 2.72 (bs, IH); 2.87 (d, IH); 3.58 (d, IH); 3.68 (d, IH); 4.10 (bs, IH); 4.31(m, 2H); 4.39 (d, IH); 4.62 (bs, IH); 4.71 (d, IH); 4.90 (dd, IH); 5.44 (s+m, 2H); 5.57 (m, 2H); 7.36(m, 5H); 7.49 (m, 2H); 7.59 (m, IH); 8.10 (d, 2H). Carbon NMR (CDC1 3 , TMS): δ 9.07, 14.41, 19.80, 21.03, 23.19, 29.30, 29.81, 32.87, 35.30, 38.66, 39.50, 50.47, 55.75, 57.93, 71.66, 73.50, 74.70, 77.21, 77.64, 77.73, 81.09, 84.47, 121.69, 126.66, 127.93, 128.75, 128.86, 130.22, 133.69, 138.88, 143.26, 156.52, 166.63, 170.69, 171.33, 171.99 206.71. Mass spectrum (FAB-High Res.) Theory for C 45 HjgN 2 O 14 +H: 849.3809 Found: 849.3842 Example 27 Preparation of Δ 12,13 -iso-baccatin HI-13-(4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxyUc acid ester (33a) 7-TES-Δ 12,13 -iso-baccatin IH-13-(4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (31a, preparation 26, 460 mg, 0.413 mM) is dissolved in acetonitrile (0.5 mL) and the solution treated with triethyl amine hydrofluoride (0.5 mL). The reaction is stirred at room temperature for 6 h. The reaction is then diluted with ethyl acetate and washed with 5 % aqueous sodium bicarbonate, 5 % aqueous sodium bisulfate and saturated brine. The organic layer is dried over sodium sulfate and evaporated under vacuum. The crude product is purified by chromatography over 50 g of HPLC grade silica gel eluting with 30 % and 40 % acetone in hexane. Fractions of 10 mL are collected, analyzing them by TLC. The major product spot is found in fractions 24-30, which upon combining and evaporating under vacuum leave of Δ I2,13 -iso-baccatin IH-13-(4S,5R)-N-(t- butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (33a). Proton NMR (CDC1 3 , TMS): δ 1.07 (s, 3H); 1.17 (s, 9H); 1.32 (s, 3H); 1.62 (s, 3H); 1.67 (s, 3H); 1.91 (m, IH); 2.16 (s, 3H); 2.24 (s, 3H); 2.31 (d, IH); 2.49 (m, IH); 2.81 (m, 2H); 3.54 (d, IH); 3.71 (d, IH); 3.83 (s, 3H); 3.92 (s, 3H); 4.35 (m, 3H); 4.65(bs, IH); 4.89 (m, IH); 5.06 (d, IH); 5.49 (bs, IH); 5.58 (d, IH); 5.67 (d, IH); 6.47 (m, IH); 6.53 (d, IH); 6.73 (s, IH); 7.20(d, IH); 7.34-7.65 (m, 8H); 8.07 (m, 2H). Carbon NMR (CDC1 3 , TMS): δ 9.14, 13.83, 14.39, 19.85, 21.09, 22.50, 29.12, 29.93, 31.8, 33.2, 35.35, 38.69, 39.60, 50.92, 55.45, 55.82, 57.99, 63.16, 71.60, 73.68, 77.37, 77.72, 80.96, 84.62, 86.27, 98.43, 105.27, 117.5, 121.81, 127.02, 128.02, 128.76, 128.83, 130.09, 133.79, 140.2, 143.21, 155.4, 158.4, 162.1, 166.6, 168.7, 170.56, 172.0, 206.74. Example 28 Preparation of 7-trifluoromethanesulfonyl-Δ 12 ' 13 -iso-baccatin UI 13-(4S,5R)-N-(t- butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (34a) A solution of Δ 12,13 -iso-baccatin HI 13-(4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (33a, 63 mg, 0.063 mM) in CH 2 C1 2 (0.4 mL) and pyridine (0.15 mL) is cooled in a -78 °C bath. Trifluoromethanesulfonic anhydride (33 μL, 0.20 mM) is added resulting in the reaction solidifying. The reaction is warmed until it melts and then is re-cooled. After lh the reaction was warmed to room temperature and stirred 10 min. The reaction is poured into saturated aq NH 4 C1 and the mixture is extracted with CH 2 C1 2 . The organic extract is washed with 1 M aq NaHSO 4 (50 mL), dried and concentrated under reduced pressure. The residue is chromatographed over silica gel (3 g), eluted with 30 % acetone in hexane. Fractions of 1 mL are collected. Concentration of fractions 17,18 leaves 7-trifluoromethanesulfonyl-Δ 12,13 -iso-baccatin IH 13-(4S,5R)-N-(t- butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (34a). Proton NMR (CDC1 3 , TMS): δ 1.11 (s, 3H); 1.17 (s, 9H); 1.77 (s, 6H); 2.20 (s, 3H); 2.21 (s, 3H); 2.34 (d, IH); 2.68 (bs, IH); 2.80 (d, IH); 2.95 (m, IH); 3.83 (s, 3H); 3.88 (m, IH); 3.93 (s, 3H); 4.34 (d, IH); 4.43 (d, IH); 4.67 (bs, IH); 4.86 (m, IH); 5.05 (m, IH); 5.53 (m, IH); 5.60 (m, IH); 5.88 (s, IH); 6.47 (m, IH); 6.53 (m, IH); 6.72 (s, IH); 7.20 (d, IH); 7.30-7.70 (m, 8H); 8.07 (m, 2H). Carbon NMR (CDC1 3 , TMS): δ 10.17, 14.12, 14.42, 19.71, 20.71, 22.36, 22.65, 29.10, 29.93, 31.59, 33.24, 38.75, 39.67, 50.93, 55.16, 55.44, 55.69, 57.57, 63.04, 72.95, 74.73, 77.20, 79.68, 80.87, 83.38, 85.86, 86.06, 98.38, 105.33, 117.61 122.78, 127.00, 127.98, 128.81, 130.09, 133.98, 140.17, 142.78, 155.29, 158.46, 162.06, 166.41, 168.91, 168.99, 170.90, 203.44. Example 29 Preparation of 7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-baccatin HI 13-(4S,5R)-N-(t- butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (35a) A solution of 7-trifluoromethanesulfonyl-Δ 12,13 -iso-baccatin IH 13-(4S,5R)-N-(t- butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (34a, Example 28) in distilled dioxane is treated with an aqueous sodium azide solution. The reaction is refluxed under nitrogen one hour. The mixture is diluted with ethyl acetate and washed with water and brine, dried over anhydrous sodium sulfate, and evaporated. The product is purified by column chromatography on silica gel 60 in ethyl acetate-methylene chloride mixtures. Evaporation of the fractions found by TLC to contain the product gives 7-deoxy-7β,8β-methano- Δ 12,I3 -iso-baccatin HI 13-(4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (35a). Example 30 Preparation of 13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-7-deoxy-7β,8β- methano-Δ 12,I3 -iso-baccatin IH (36) Following the procedure of example 5, 7-deoxy-7β,8β-methano-Δ 12,13 -iso-baccatin HI 13- (4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (35a) is stirred in a 4: 1 mixture of acetic acid and water at room temperature under an inert atmosphere 4 days. The reaction is diluted with ethyl acetate and washed multiple times with water and aqueous sodium bicarbonate. The organic layer is dried over anhydrous sodium sulfate and evaporated. The product is chromatographed on silica gel 60 (230-400 mesh) in acetone-hexane mixtures. Evaporation of the fractions found to contain product by TLC leaves 13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-7-deoxy-7β,8β-methano-Δ I2,13 -iso-baccatin HI (36). Example 31 Preparation of 13-(N-(t-butylaminocarbonyl)-β-phenylisoserinyl)-7-deoxy-7β,8β- methano-Δ I2,13 -iso-baccatin IH (36) and 13-(N-(t-butylaminocarbonyl)-β-phenylisoserinyl)-7- triflluoromethanesulfonyl-Δ 12,13 -iso-baccatin HI (37) A solution of Δ J2,13 -iso-baccatin m-13-[(4S,5R)-N-t-butylaminocarbonyl-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester] -7-triflate (0.20 g, 0.18 mM) in 2 mL of (80:20) acetic acid: methanol is stirred at room temperature for 1.3 hours. The reaction is diluted with ethyl acetate and washed with 5% aqueous sodium bicarbonate. The organic layer is dried over anhydrous sodium sulfate and concentrated. The crude product is chromatographed on silica gel 60 in acetone-hexane mixtures, resulting in partial conversion to 7,19-methano-13- (N-t-butylaminocarbonyl-β-phenylisoserinyl)-Δ 12,I3 -iso-baccatin HI. The products eluting from this column are re-chromatographed in ethyl acetate-methylene chloride mixtures to give 13-(N- (t-butylaminocarbonyl)-β-phenylisoserinyl)-7-triflluoromethanesulfonyl-Δ 12,13 -iso-baccatin HI (37, 70 mg) and 13-(N-(t-butylaminocarbonyl)-β-phenylisoserinyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso- baccatin m (36, 41 mg). Data for 13-(N-(t-butylammocarbonyl)-β-phenylisoserinyl)-7-triflluoromethanesulfonyl-Δ 12 ' 13 -iso- baccatin IH (37) Proton NMR (CDC1 3 , TMS): δ 1.09 (s); 1.11 (s); 1.17 (s); 1.24 (s); 1.76 (s); 2.1(m); 2.18 (s); 2.47 (s); 2.65 (m); 2.90 (m); 3.83 (d); 4.31(d); 4.43 (d); 4.73 (d); 4.88 (m); 5.32 (bs); 5.47(m); 5.58 (d); 5.85(s); 7.30-7.63 (m); 8.09 (d). Carbon NMR (CDC1 3 , TMS): δ 10.09, 14.36, 19.69, 20.68, 22.62, 23.00, 29.13, 29.22, 29.73, 31.54, 33.01, 33.53, 38.67, 39.57, 50.68, 55.13, 55.41, 57.50, 72.79, 74.24, 74.66, 79.59, 83.30, 85.89, 122.70, 126.72, 127.99, 128.61, 128.81, 128.86, 130.22, 133.88, 138.65, 142.85, 156.47, 166.41, 168.98, 170.68, 171.16, 203.40. Data for 13-(N-(t-butylan__inocarbonyl)-β-phenylisoserinyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso- baccatin IH (36) Proton NMR (CDC1 3 , TMS): δ 1.04 (s, 9H); 1.12 (s); 1.31 (s+m); 1.55 (s); 1.73 (m); 2.17 (s+m); 2.41(m, IH); 2.55 (s, 3H); 2.73 (bs, IH); 2.91 (d, IH); 3.86 (d, IH); 4.09 (d, IH); 4.29 (bs, IH); 4.41 (d, IH); 4.70 (d, IH); 4.78 (m, IH); 5.08 (d, IH); 5.21 (d, IH); 5.50 (m, IH); 5.62 (d, IH); 7.27-7.65 (m, 10 H); 8.18 (m, 2H). Carbon NMR (CDC1 3 , TMS): δ 12.80, 14.22, 20.86, 21.08, 22.44, 25.79, 28.77, 29.20, 30.09, 32.44, 32.81, 36.69, 39.70, 50.38, 55.03, 55.22, 74.39, 75.70, 78.29, 78.41, 78.87, 80.47, 85.15, 122.40, 126.65, 127.83, 128.77, 129.02, 130.38, 133.64, 139.15, 141.77, 156.19, 167.28, 169.76, 170.36, 171.02, 203.64. Example 32 Preparation of 13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-7-deoxy-Δ 6 ' 7 -Δ 12 13 - iso-baccatin IH (38) Following the procedure of Example 16, a solution of 13-(N-(t-butylaminocarbonyl)-β- phenyl isoserinyl)-7-trifluoromethanesulfonyl-Δ 12,13 -iso-baccatin IH (37) and l,8-diazabicyclo[5.4.0]undec-7-ene in THF is stirred at room temperature for 1 hr, at 50 °C for 2.5 hr, and at reflux temperature for 3 hr, after which reaction is complete. EtOAc is added and the solution washed with saturated aq NaHCO 3 and with saturated aq NaCl. The organic layer is dried (Na 2 SO 4 ), filtered, and evaporated under reduced pressure. The residue is flash chromatographed over silica gel using a solution in CH 2 C1 2 for application to the column. The column is eluted with acetonitrile-methylene chloride mixtures. Fractions containing the desired material are detected by TLC and are combined to give 13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-7-deoxy-Δ 6 ' 7 -Δ 12,13 -iso-baccatin m (38). Example 33 Preparation of 7-deoxy-Δ 6,7 -Δ 12 - 13 -iso-baccatin m 13-(4S,5R)-N-(t- butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (39a) Following the procedure of Example 16, a solution of 7-trifluoromethanesulfonyl-Δ 12 ' 13 - iso-baccatin IH 13-(4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (34a) and l,8-diazabicyclo[5.4.0]undec-7-ene in THF are stirred at room temperature for 1 hr, at 50 °C for 2.5 hr, and at reflux temperature for 3 hr, after which reaction is complete. EtOAc is added and the solution washed with saturated aq NaHCO 3 and with saturated aq NaCl. The organic layer is dried (Na 2 SO 4 ), filtered, and evaporated under reduced pressure. The column is eluted with acetonitrile-methylene chloride mixtures. Fractions containing the desired material are detected by TLC and are combined to give 7-deoxy-Δ 6,7 - Δ 1 ' 13 -iso-baccatin IH 13-(4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (39a). Example 34 Preparation of 13-[N-(t-butylaminocarbonyl)-β-phenyl isoserinyl]-7-deoxy-Δ 6,7 - Δ 12 I3 -iso-baccatin m (38) Following the procedure of Example 5, 7-deoxy-Δ 6,7 -Δ 12,13 -iso-baccatin m 13-(4S,5R)-N- (t-butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (39a) is stirred in a 4: 1 mixture of acetic acid and water at room temperature under an inert atmosphere 4 days. The reaction is diluted with ethyl acetate and washed multiple times with water and aqueous sodium bicarbonate. The organic layer is dried over anhydrous sodium sulfate and evaporated. The product is chromatographed on silica gel 60 (230-400 mesh) in acetone-hexane mixtures. Evaporation of the fractions found to contain product by TLC leaves 13-[N-(t-butylaminocarbonyl)-β-phenyl isoserinyl]-7-deoxy-Δ 6,7 -Δ 12,13 -iso-baccatin HI (38). Example 35 Preparation of 7-(O-ethoxymethyl)-Δ 12,13 -iso-baccatin IH-13-(4S,5R)-N-Boc-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxyhc acid ester (40a) Δ 12,13 -Iso-baccatin IH-13 (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (10a) is stirred at room temperature under nitrogen in methylene chloride and the solution treated with chloroethyl ethyl ether and diisopropylethyl amine. The reaction is stirred for 2 days, when it is complete as shown by TLC. The reaction is then partitioned between methylene chloride-water. The layers are separated and the water layer reextracted with methylene chloride. The organic layers are dried over sodium sulfate, combined and evaporated under vacuum. The crude product is chromatographed over silica gel, eluting with acetone-hexane mixtures. Fractions contain the product are found by TLC and are combined and evaporated under vacuum leaving 7-(O-ethoxymethyl)-Δ 1 ,13 -iso-baccatin HI-13- (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxyUc acid ester (40a). Example 36 Preparation of 7-(O-ethoxymethyl)-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso- baccatin HI (41) Following the procedure of example 5, 7-(O-ethoxymethyl)-Δ 12 ' 13 -iso-baccatin m-13- (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxyUc acid ester (40a) is stirred in a 4:1 mixture of acetic acid and water at room temperature under an inert atmosphere 4 days. The reaction is diluted with ethyl acetate and washed multiple times with water and aqueous sodium bicarbonate. The organic layer is dried over anhydrous sodium sulfate and evaporated. The product is chromatographed on silica gel 60 (230-400 mesh) in acetone-hexane mixtures. Evaporation of the fractions found to contain product by TLC leaves 7-(O-ethoxymethyl)-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin HI (41). Example 37 Preparation of 7-(O-ethoxymethyl)-Δ 1 >13 -iso-baccatin HI-13-(4S,5R)-N-(t- butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (42a) Δ 12,13 -Iso-baccatin m-13 (4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4- phenyl-5-oxazolidinecarboxylic acid ester (33a, 70mg, 0.070 mM) is stirred at room temperature under nitrogen in 1 mL of methylene chloride and the solution treated with chloromethyl ethyl ether (32μl, 0.35 mM) and diisopropylethyl amine (61 μl, 0.35 mM). After 1 hour the reaction is treated with addtional diisopropylethyl amine (5 μl). The reaction is stirred for 2 days, when it is still incomplete as shown by TLC. Additional chloromethyl ethyl ether (15 μl) and diisopropylethyl amine (30 μl) is added and the reaction stirred an additional 12 days. The reaction is then partitioned between methylene chloride- water. The layers are separated and the water layer reextracted with methylene chloride. The organic layers are dried over sodium sulfate, combined and evaporated under vacuum. The crude product is chromatographed over silica gel (lOg), eluting with (10-90) acetone-toluene. Fractions of 3 mL are collected, analyzing them by TLC. Impure product is found in fractions 9-20. These are combined, evaporated under vacuum and the residue rechromatographed over an E Merck size A prepacked silica gel column eluting with (10-90) acetone-hexane. Fractions of 3 mL are collected. The product is found in fractions 10-15, which upon combining and evaporating under vacuum leave 7-ethoxymethyl-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxyhc acid ester (42a). TLC (silica gel GF): (20-80) acetone-hexane; R f . 0.59. Proton NMR (CDC1 3 , TMS): δ 1.07-1.18 (t, 3H); 1.18 (s, 9H); 1.30 (s, 3H); 1.68 (s, 3H); 1.72 (s, 3H); 1.89-2.03 (m,lH); 2.16 (s, 3H); 2.19 (s, 3H); 2.26-2.39 (d, IH); 2.64 (s, IH); 2.73-2.85 (d, IH); 2.84-2.96 (m, lH);3.30-3.43 (m, IH); 3.61-3.75 (m,lH); 3.83 (s, 3H); 3.86- 3.92 (d, IH); 3.92 (s, 3H); 4.00-4.10 (q, IH); 4.25-4.34 (d, IH); 4.36-4.44 (d, IH); 4.60-4.74 (m, 3H) 4.84-4.93 (dd, IH); 5.04-5.09 (d, IH); 5.50-5.58 (d, IH); 5.64-5.70 (d, IH); 6.44-6.51 (dd, IH); 6.51-6.56 (d, IH); 6.75 (s, IH); 7.16-7.24 (d, IH); 7.32-7.57 (m ,7H); 7.57-7.65 (t, IH); 8.03-8.10 (d, 2H). Example 38 Preparation of 7-(O-ethoxymethyl)-13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-Δ I2,13 -iso-baccatin m (43) 7-(O-ethoxymethyl)-Δ 12,I3 -iso-baccatin iπ-13-(4S,5R)-N-(t-butylammocarbonyl)-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (42 a, 45 mg, 0.043 mM) is stirred in a mixture of acetic acid (1.5 mL) and water (0.5 mL) at room temperature. The reaction is followed by TLC and is complete in 3 hours. The reaction is then freeze-dried. The crude product is purified by HPLC over an E. Merck size A prepacked silica gel column, eluting with a gradient of (25-75) to (35-65) acetone-hexane. Fractions of 3 ml are collected, analyzing them by TLC. Product is found in fractions 7-11, which are combined and evaporated under vacuum to give 7-(O-ethoxymethyl)-13-(N-(t-butylamino-carbonyl)-β-phenyl isoserinyl)-Δ 12,13 - iso-baccatin IH (43) as a solid. TLC(silica gel 60): (30-70) acetone-hexane; Rf: 0.24 Proton NMR (CDC1 3 ; TMS): δ 1.07-1.20 (m, 15H); 1.24 (s, 3H); 1.58 (s, 3H); 1.67 (s, 3H); 1.87-2.02 (t, IH); 2.02-2.14 (d, IH); 2.16 (s, 3H); 2.55 (s, 3H); 2.77-2.94 (m, 2H); 3.27- 3.42 (m, IH); 3.60-3.72 (m, IH); 3.84-3.90 (d, IH); 3.97-4.06 (dd, IH); 4.24-4.31 (d, IH); 4.37- 4.44 (d, IH); 4.54 (s, lH);4.57-4.64 (d, IH); 4.64-4.72 (m, 2H); 4.87-4.95 (dd, IH); 5.27-5.35 (d, IH); 5.42-5.49 (dd, IH); 5.49-5.55 (d, IH); 5.75 (s, IH); 7.14-7.42 (m, 5H); 7.44-7.55 (t, 2H); 7.55-7.63 (t, IH); 8.07-8.15 (d, 2H). Example 39 Preparation of 7-deoxy-7β,8β-methano-baccatin IH (44) A solution of 7-trifluoromethanesulfonyl-baccatin IH (87 mg, 0.12 mM) in distilled dioxane (1.5 mL) is treated with an aqueous sodium azide solution (0.10 g, 1.5 mM NaN 3 in 0.30 mL water.) The reaction is refluxed under nitrogen one hour. The mixture is diluted with ethyl acetate and washed with water and brine, dried over anhydrous sodium sulfate, and evaporated. The product is purified by column chromatography on silica gel 60 in 25% ethyl acetate-methylene chloride. Evaporation of the fractions found by TLC to contain the product gives 7-deoxy-7β,8β-methano-baccatin IH (44) as crystals. Proton NMR (CDC1 3 , TMS): δ 1.10 (s, 3H); 1.22 (s, 3H); 1.35 (m, IH); 1.64 (m, IH); 1.78 (s, IH); 2.03 (s+m, 4H); 2.21 (s, 3H); 2.26 (s, 3H); 2.20-2.55 (m, 5H); 4.04 (d, IH, J-8.5 Hz); 4.18 (d, IH, J-7.5 Hz); 4.30 (d, IH, J-8.5 Hz); 4.74 (d, IH); 4.83 (m, IH); 5.63 (d, IH, J-7.5 Hz); 6.35 (s, IH); 7.49 (m, 2H); 7.62 (m, IH); 8.13 (m, 2H). Carbon NMR (CDC1 3 , TMS): 15.15, 15.28, 20.43, 20.82, 21.99, 25.90, 26.35, 31.63, 35.19, 38.57, 38.76, 42.20, 67.51, 75.30, 76.20, 76.49, 79.23, 79.91, 84.73, 128.50, 129.33, 129.99, 132.59, 133.54, 144.19, 167.20, 169.63, 170.00, 202.08. Example 40 Preparation of 7-α-azido-baccatin HI (45) A mixture of 7-trifluoromethanesulfonyl-baccatin m (102 mg, 0.14 mM), sodium azide (13 mg, 0.20 mM), and 18-crown-6 (32 mg, 0.12 mM) in l,3-dimethyl-3,4,5,6-tetrahydro-2(lH)- pyrimidinone (1.0 mL) is stirred at room temperature overnight under an inert atmosphere. The reaction is partitioned between ethyl acetate and water. The organic layer is dried over anhydrous sodium sulfate and evaporated. The crude product is purified by column chromatography on silica gel 60 in 15% ethyl acetate—methylene chloride. The product is further purified by crystallization from methylene chloride-hexane giving 7-α-azido-baccatin IH (45). Proton NMR (CDC1 3 , TMS): δ 0.96 (s, 6H); 1.59 (s, 3H); 1.91(s, 3H); 2.13 (s, 3H); 2.25 (s, 3H); 2.10-2.35 (m, 4 H); 2.47 (m, IH); 3.80 (m, 2H); 4.07 (d, IH, J-8.0 Hz); 4.33 (d, IH, J-8.0 Hz); 4.60 (s+m, 2H); 4.99 (dd, IH); 5.35 (d, IH); 5.48 (d, IH, J-7.2 Hz); 6.79 (s, IH); 7.59 (m, 2H); 7.69 (m, IH); 8.05 (m, 2H). Carbon NMR (CDC1 3 , TMS): 15.40, 17.31, 20.67, 22.20, 25.93, 29.81, 39.22, 40.63, 41.73, 55.57, 64.28, 65.91, 75.33, 76.91, 77.33, 78.22, 80.44, 80.94, 128.77, 129.58, 129.98, 130.28, 133.33, 145.43, 165.30, 168.75, 169.09, 207.11. Example 41 Preparation of 13-(N-Boc-2'-TES-β-phenyl isoserinyl)-Δ 12 ' I3 -iso-baccatin HI (46) 13-(N-Boc-β-phenyl isoserinyl)-Δ 12 ' 13 -iso-baccatin IH (7, 60 mg, 0.07 ImM) is stirred at room temperature under nitrogen in freshly distilled pyridine (0.7mL). The solution is cooled in an ice bath and treated with triethylsilyl chloride (13 μl, 0.078mM). The reaction is followed by TLC. No reaction is seen after 1 hr at 0° C and 1 hr at room temperature. Thus, TES chloride is repeatedly added in the portions above until a total of 12 equivalents are added, at which point the reaction in seen to go to completion. This requires a total reaction time of 18 hours. The reaction is then partitioned between water-ethyl acetate. The layers are separated and the aqueous layer reextracted with ethyl acetate. The organic layers are combined, dried over sodium sulfate and evaporated under vacuum. Toluene is added and reevaporated. The crude product is chromatographed over silica gel (lOg), eluting with (30-70) acetone-hexane. Fractions of 3 mL are collected, analyzing them by TLC. Fractions 7-11 are combined and evaporated under vacuum to give 13-(N-Boc-2'-TES-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin HI (46) as a solid. TLC(silica gel 60): 30-70 acetone-hexane; Rf: 0.43 Proton NMR (CDC1 3 ; TMS): δ 0.23-0.49 (m, 6H); 0.69-0.82 (t, 9H); 1.05 (s, 3H); 1.18 (s, 9H); 1.32 (s, 3H); 1.62 (s, 3H); 1.63 (s, 3H); 1.87-2.02 (m, IH); 2.03-2.146(d, IH); 2.22 (s, 3H); 2.46-2.60 (m, IH); 2.64 (s, 3H); 2.79 (s, IH); 2.84-2.99 (d, IH); 3.50-3.57 (d, IH); 3.70-3.77 (d, IH); 4.32-4.46 (m, 3H); 4.62 (s, IH); 4.92-5.00 (dd, IH); 5.39-5.47 (bd, IH); 5.49 (s, IH); 5.53-5.63 (m, 2H); 7.24-7.43 (m, 5H); 7.44-7.53 (t, 2H); 7.53-7.62 (t, IH); 8.07- 8.16 (d, 2H). Example 42 Preparation of 7-(O-ethoxymethyl)-13-(N-Boc-2'-TES-β-phenyl isoserinyl)-Δ 12,13 - iso-baccatin IH (47) 13-(N-Boc-2'-TES-β-phenyl isoserinyl)-Δ 12ιI3 -iso-baccatin HI (46, 59mg, O.OόlmM) is stirred at room temperature under nitrogen in methylene chloride (0.5mL) and the solution treated with diisopropylethyl amine (55μl, 0.3 ImM) and chloromethyl ethyl ether (28μl, 0.305mM). The reaction is followed by TLC and is found to be complete in 3.5 days. The crude reaction mixture is purified by HPLC over an E. Merck size A prepacked silica gel column, eluting with (20-80) acetone-hexane. Fractions of 3 mL are collected, analyzing them by TLC. The product is found in fractions 10-16, which are combined and evaporated under vacuum to give 7-(O-ethoxymethyl)-13-(N-Boc-2'-TES-β-phenyl isoserinyl)-Δ I2,13 -iso-baccatin HI (47) as a solid. TLC (silica gel 60): (25-75) acetone-hexane; Rf: 0.50 Proton NMR (CDC1 3 ; TMS): δ 0.22-0.49 (m, 6H); 0.70-0.80 (t, 9H); 1.08-1.16 (m, 3H); 1.20 (s, 9H); 1.27 (s, 3H); 1.30 (s, 3H); 1.66 (s, 3H); 1.69 (s, 3H); 1.90-2.04 (t, IH); 2.04- 2.14 (d, IH); 2.17 (s, 3H); 2.64 (s, 3H); 2.80-2.98 (m, 2H); 3.30-3.42 (m, IH); 3.61-3.75 (m, IH); 3.86-3.94 (d, IH); 4.03-4.13 (dd, IH); 4.27-4.36 (d, IH); 4.38-4.46 (d, IH); 4.56-4.65 (d, IH); 4.62 (s, IH); 4.67-4.75 (md IH); 4.90-4.98 (dd, IH); 5.38-5.49 (bd, IH); 5.51-5.60 (m, 2H); 5.80 (s, IH); 7.25-7.53 (m, 7H); 7.53-7.61 (t, IH); 8.08-8.16 (d, 2H). Example 43 Preparation of 7-(O-ethoxymethyl)-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso- baccatin UI (41) 7-(O-ethoxymethyl)-13-(N-Boc-2'-TES-β-phenyl isoserinyl)-Δ 12 - 13 -iso-baccatin HI (47, 62 mg, 0.06 ImM) is stirred at room temperature under nitrogen in (80-20) acetic acid-water (4 mL). The reaction is followed by TLC and is found to be complete in 24 hours. The reaction is then freeze-dried. The crude product is purified by HPLC over an E. Merck size A prepacked silica gel column, eluting with (25-75) acetone-hexane. Fractions of 3 mL are collected, analyzing them by TLC. The product is found in fractions 17-24, which are combined and evaporated under vacuum to give 7-(O-ethoxymethyl)-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso- baccatin HI (41) as a solid. TLC (silica gel 60): (25-75) acetone-hexane; Rf: 0.33 .Proton NMR (CDC1 3 ; TMS): δ 1.10-1.18 (m, 6H); 1.24 (s, 9H); 1.62 (s, 3H); 1.68 (s, 3H); 1.88-2.04 (t, IH); 2.04-2.15 (d, IH); 2.18 (s, 3H); 2.60 (s, 3H); 2.83-2.97 (m, 2H); 3.28- 3.42 (m, IH); 3.60-3.73 (m, IH); 3.84-3.90 (d, IH); 4.00-4.10(dd, IH); 4.25-4.34 (d, IH); 4.36-4.45 (d, IH); 4.57-4.65 (d, IH); 4.66-4.74 (m, 2H); 4.87-4.96 (dd, IH); 5.36-5.50 (m, 2H); 5.50-5.57 (d, IH); 5.77 (s, IH); 7.30-7.55 (m, 7H); 7.55-7.64 (t, IH); 8.07-8.17 (d, 2H). Example 44 Preparation of 13-(N-(t-butylaminocarbonyl)-2'-TES-β-phenyl isoserinyl)-Δ 12,13 -iso- baccatin UI (48) Following the procedure of Example 41 but starting with 13-(N-(t-butylaminocarbonyl)- β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin UI (32b) is prepared 13-(N-(t-butylaminocarbonyl)-2'- TES-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin HI (48). Example 45 Preparation of 7-(O-ethoxymethyl)-13-(N-(t-butylaminocarbonyl)-2'-TES-β-phenyl isoserinyl)-Δ 12,I3 -iso-baccatin IE (49) Following the procedure of Example 42 but starting with 13-(N-(t-butylaminocarbonyl)- 2'-TES-β-phenyl isoserinyl)-Δ 12,I3 -iso-baccatin HI (48) is prepared 7-(O-ethoxymethyl)-13-(N-(t- butylaminocarbonyl)-2'-TES-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin IH (49) Example 46 Preparation of 7-(O-ethoxymethyl)-13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-Δ 12 ' I3 -iso-baccatin HI (43) Following the procedure of Example 43 but starting with 7-(O-ethoxymethyl)-13-(N-(t- butylaminocarbonyl)-2'-TES-β-phenyl isoserinyl)-Δ I2,13 -iso-baccatin IH (49) is prepared 7-(O- ethoxymethyl)-13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin HI (43). Example 47. 7-Triethylsilyl-12,13-«obaccatin m, 13-(4S,5R)-N-carbobenzyloxy-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxyhc acid ester (51 a,b) A slurry of (4S,5R)-N-carbobenzyloxy-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidine carboxylic acid potassium salt (9.63 g , 19.2 mmol) in EtOAc (1.2 L) is stirred vigorously during the addition of 5% NaHSO 4 solution until the pH is < 2. The layers are separated and the EtOAc is washed with more 5% NaHSO 4 solution. The EtOAc layers are combined, washed with half-saturated brine, dried ( Na^O,,), filtered and evaporated at a reduced pressure. The residue is redissolved in EtOAc (50 mL), toluene is added and the solvent re-evaporated. Toluene is added and evaporated two more times giving an oil (10.37 g). The oil is dissolved in CH 2 C1 2 (60 mL, purged with argon) plus toluene (75 mL, purged with argon) and then 4- dimethylaminopyridine (0.965 g, 7.91 mmol) added. The solution is purged with argon and added to a solution of 7-TES-12,13-wobaccatin HI (3) (11.3 mmol, purged with argon) in CH 2 C1 2 (125 mL) plus toluene (65 mL). The acid is rinsed in with additional CH 2 C1 2 (2 x 15 mL) and then toluene (10 mL). Immediately after the solutions are combined at room temperature, 1,3-dicyclohexylcarbodiimide (4.66 g, 22.6 mmol) is added. Tic indicates complete reaction after one hour. The reaction is worked xp after an addional 0.75 hour by dilution with toluene and chilling with an ice-water bath. The precipated solids (dicyclohexylurea, DCU) are removed by filtration. The filtrates are diluted with EtOAc and washed with 5% NaHSO 4 solution and 5% NaHCO 3 solution. More DCU precipitated during the NaHCO 3 wash which is removed by filtration through Celite. A half-saturated brine wash completes the workup. The organic layer is dried (Na^O , filtered, and evaporated at a reduced pressure to yield an oil. The oil is chromatographed on 790 g of 40-63 μm silica gel packed in two Michel-Miller (47 x 450 mm, Ace Glass) columns connected in series. The sample is applied in the minimum amount of acetone and eluted with 20% acetone/hexane (3 L), 25% acetone/hexane (4 L), and 30% acetone/hexane collecting fractions of 50 mL each. Fractions 100-104 (0.50 g) contain an impurity which is removed by a second chromatography. Fractions 105-127 (14.31 g) contain DCU as an impurity which is removed by a second chromatography on 40-63 μm silica gel (two Michel-Miller 47 x 450 mm columns) using the minimum amount of EtOAc for application to the column. The product is eluted with 10% EtO Ac/toluene collecting fractions of 50 mL each. Eluted first in fractions 24-40 (1.30 g, 7%) is 7-Triethylsilyl-12,13-wøbaccatin HI, 13-(4S,5R)- N-carbobenzyloxy-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester, less polar isomer (51a) Η NMR (CDC1 3 ,TMS) δ 8.05 (m, 2H), 7.63-7.37 (m, 8H), 7.22-6.99 (m, 6H), 6.48,6.39 (m, 2H), 5.97 (s, IH), 5.54 (d, IH, J - 5.4 Hz), 5.45 (d, IH, J - 2.6 Hz), 5.01 (m, 3H, -OCH 2 Ph), 4.88 (m, IH), 4.43 (m, IH), 4.38 (d, IH, J - 8.5 Hz), 4.27 (d, IH, J - 8.5) 3.85 (m, IH), 3.82 (s, 6H), 2.77 (d, IH, J - 18.1 Hz), 2.52 (s, IH), 2.47 (m, IH), 2.27 (d, IH, J - 17.4 Hz) 2.19 (s, 3H), 2.15 (s, 3H), 1.88 (m, IH), 1.78, 1.61, 1.28, 1.16 (4s, 12H), 0.89 (m, 9H), 0.53 (m, 6H); mass spectrum: 1146.4927, C 63 H 75 NO 17 Si + H requires 1146.4882, 1146, 1116, 1038, 1010, 418, 374, 284, 254, 151, 105, 91, 43 m/z; Fractions 41-62 (5.14 g, 28%) contain a mixture of isomers. Fractions 63-130 (7.08 g, 38%) contain 7-Triethylsilyl-12,13-wobaccatin HI, 13-(4S,5R)- N-carbobenzyloxy-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester, more polar isomer (51b) Η NMR (CDC1 3 TMS) δ 8.02 (m, 2H), 7.62 (m, IH), 7.48,7.40 (m, 8H), 7.24-7.14 (m, 5H), 6.74 (m, 2H), 6.44 (m, 2H), 5.87 (s, IH), 5.48 (d, IH, J - 4.7 Hz), 5.38 (d, IH, J - 5.9 Hz), 4.88 ( d, IH, 12.2 Hz), 4.81 (m, IH), 4.73 (d, IH, J - 11.8 Hz), 4.61 (d, IH, J - 5.9 Hz), 4.34 (m, IH), 4.33 (d,lH J- 8.6 Hz), 4.22 (d, IH, J - 8.9 Hz), 3.82 (s, 3H), 3.72 (d, IH J - 5.5 Hz), 2.58 (d, IH, J - 17. 5 Hz), 2.43 (m, 2H), 2.16 (s, 3H), 2.14 (m, IH), 1.89(s, 3H), 1.82 (m, IH), 1.56,1.42,1.21,1.10 (4s, 12H), 0.88 (m, 9H), 0.51 (m, 6H); mass spectrum: 1146.4904, C 63 H 7 jNO 17 Si + H requires 1146.488, 1146, 1116, 1103, 1038, 1010, 446, 418, 374, 284, 254, 151, 105, 91, 43 m/z. Tic: Rf (15% Ethyl Acetate/Toluene) = 0.22, 0.33 for the two product isomers. Example 48. N-Debenzoyl-N-benzyloxycarbonyl-12,13-wotaxol (52) A solution of 7-triethylsilyl-12,13-wobaccatin IH, 13-(4S,5R)-N-carbobenzyloxy-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (51a,b; 646.5 mg, 0.564 mmole) in MeOH (35 mL) is cooled to 0-10°C with an ice bath. Meanwhile, a 0.1 molar solution of HCI in MeOH is prepared by the slow addition of acetyl chloride (0.46 mL) to slightly cooled MeOH (30 mL). This solution is added to the solution of 51a,b in one portion. The resulting solution is allowed to warm to room temperature. The disappearance of the starting material and the appearance of the ortho-ester intermediate and the product is followed by TLC (50% acetone/hexane and 5% CH 3 CN/CH 2 C1 2 ) and after 1.5 hours, water (6.2 mL) is added to the blue solution. The less polar ortho-ester intermediate is converted to the desired product within an additional hour. The reaction mixture is diluted with EtOAc (200 mL) and saturated aq. Na 2 C0 3 (200 mL) solution is added. About one half of the organic layer is removed by rotoevaporation to maximize recovery. The layers are separated, the aqueous layer back-extracted with EtOAc and the combined organic layers are washed with saturated aq. NaCl solution. The organic layer is filtered through Na 2 SO 4 and evaporated under vacuum. The crude solids (0.589 g) are flash- chromatographed using 6 inches of silica gel in a 30 mm column. The elution solvent is 42.5% EtOAc/hexane (250 mL), 45% EtOAc/hexane(250 mL) and 50% EtOAc/hexane (250 mL) and 20 mL fractions are collected. Fractions 13-16 are combined, the solvent is evaporated and replaced with acetone/hexane. Evaporation of the acetone-haxane under reduced pressure gives N-debenzoyl-N-benzyloxycarbonyl-12,13-«σtaxol (0.434 g, 87%) as a white solid. Tic: Silica gel; 40% acetone/hexane; starting material Rf - 0.53, 52 Rf - 0.33, ortho- ester Rf - 0.39. IH NMR (CDC13, TMS), δ 8.18 (d, J - 7.2 Hz, 2H), 7.33-7.60 (m, 9H), 7.19 (m, 3H), 6.96 (m, 2H), 5.75 (d, IH, J = 10.0 Hz), 5.56 (d, IH, J = 5.9 Hz), 5.51 (d, IH, J - 10.0 Hz), 5.44 (s, IH), 4.91 (m, IH), 4.84 (dd, 2H, J - 12.6 Hz), 4.74 (s, IH), 4.33-4.42 (m, 3H, H7), 3.67 (d, IH, J = 3.7 Hz), 3.47 (bs, IH), 3.26 (bs, IH), 2.94 (d, IH, J - 19.0 Hz), 2.74 (s, IH), 2.59 (s, 3H), 2.50 (m, IH), 2.23 (s, 3H), 1.92 (m, IH), 1.88 (d, IH, J - 19.0 Hz), 1.62 (s, 3H), 1.58 (s, 3H), 1.25 (s, 3H), 1.04 (s, 3H). Example 49. N-Debenzoyl-N-benzyloxycarbonyl-2'-triethylsilyl-12,13-wotaxol (53) A solution of the N-debenzoyl-N-benzyloxycarbonyl-12,13-wotaxol (52; 6.61 g, 7.48 mmol) in freshly distilled pyridine (60 mL) under a nitrogen atmosphere is cooled to 0 °C with an ice-water bath. Chlorotriethylsilane (5.0 mL, 30.6 mmol) is added dropwise from a syringe over a three minute period. The temperature monitored internally does not rise above 1°C. The cooling bath is removed after the addition is complete. Tic indicates complete reacton after one hour. Workup involves dilution with EtOAc (600 mL) and washing with half-saturated CuSO 4 (2 x 100 mL), saturated CuSO 4 (2 x 50 mL), water (2 x 100 mL), NaHCO 3 (1 xlOOmL), and brine (1 x lOOmL). All aqueous layers are back extracted. The organic layers are combined, dried (Na 2 SO 4 ), filtered and evaporated at a reduced pressure to yield 8.23 g (theory - 7.47 g) of a greasy white solid. The solid is chromatographed on 400 g of 40-63 μm silica gel in a Michel-Miller (47 x 450 mm) column. The sample is applied in the minimum amount of EtOAc and eluted with 30% EtOAc/hexane collecting fractions of 50 mL each. N-Debenzoyl- N-benzyloxycarbonyl-2'-triethylsilyl-12,13-«otaxol is obtained in fractions 25-45 (6.45 g, 86%). tic: silica gel; 1:1 EtOAc/hexane; starting material Rf - 0.27, product Rf - 0.62. Η NMR (CDC1 3 ,TMS) δ 8.17 ( d, 2H, J - 7.1 Hz), 7.55-6.97 (m, 15H), 5.82 (d, IH, J = 9.8 Hz), 5.56 (d, IH, J - 5.9), 5.51 (d, IH, J - 9.9 Hz), 5.46(s, IH), 4.94 (m, IH), 4.80 (m, 2H), 4.64 (d, IH), 4.38 (m, IH), 3.69 (d, IH, J - 6.0 Hz), 3.49 (d, IH, J - 4.2), 2.92 (d, IH, J - 18.5 Hz), 2.76 (s, IH), 2.64 (s, 3H), 2.50 ( m, IH), 2.22 (s, 3H), 1.96 (m, IH), 1.88 (m, IH), 1.63, 1.59, 1.26, 1.04 (4s, 12H), 0.74 ( m, 9H), 0.35 (m, 6H). Example 50. N-Debenzoyl-N-benzyloxycarbonyl-12,13-wotaxol-7-O-triflate (54) A solution of N-debenzoyl-N-benzyloxycarbonyl-2'-triethylsilyl-12,13-wotaxol (53; 2.0 g) in CH 2 C1 2 (12.2 mL) and pyridine (4.12 mL) is cooled to -30°C in a 33% MeOH/water/dry ice bath. Triflic anhydride (2.02 mL) is slowly added via a syringe over 5 minutes keeping the temperature below -14°C. At the end of the addition, the reaction mixture is allowed to warm to room temperature. Aliquots of the yellow-orange solution are taken over 6 hours and quenched into EtOAc and saturated aq. CuSO 4 solution. The organic layer is checked by TLC (25% EtOAc/hexane) and just a trace of starting material is noted after 6 hours. The reaction mixture is quenched into EtOAc (100 mL) and saturated aq. CuSO 4 solution (100 mL). The layers are separated and the organic layer is washed separately with saturated aq. copper sulfate solution (100 mL) and water (100 mL). The water wash is back-extracted with EtOAc (25 mL) and combined with the main organic layer and then washed with saturated aq. NaHCO 3 and NaCl solutions respectively. The organic layer is dried through Na 2 SO 4 and the solvent is removed by rotoevaporation. The residual oil is dissolved in a small amount of acetone and hexane is added until cloudiness develops. The solvent is removed and the residue is subjected to high vacuum to give N-Debenzoyl-N-benzyloxycarbonyl-12,13-wøtaxol-7-O-triflate (54) as a yellow solid (2.20 g, 97%). Tic: Silica gel; 50% EtOAc/hexane; starting material Rf - 0.35, triflate 54 Rf - 0.57. Η NMR (CDC1 3 , TMS), δ 8.16 (d, J - 7.1 Hz, 2H), 7.60-7.50 (m, 3H), 7.48-7.29 (m, 5H), 7.17 (m, 3H), 6.96 (m, 2H), 5.86 (s, IH), 5.83 (d, J = 10.0 Hz, IH), 5.58 (d, J - 6.7 Hz, IH), 5.54 (m, IH), 5.50 (d, J - 8.1 Hz, IH), 4.90 (m, IH), 4.86 (d, J - 12.8 Hz, IH), 4.79 (d, J - 12.5 Hz, IH), 4.64 (d, J - 1.8 Hz, IH), 4.43 (d, J - 8.7 Hz, IH), 4.38 (d, J - 8.7 Hz, IH), 3.83 (d, J - 5.7 Hz, IH), 2.99 (m, IH), 2.89 (d, J = 20.6 Hz, IH), 2.66 (s, 3H), 2.22 (m, IH), 2.19 (s, 3H, ), 1.87 (d, J - 19.2 Hz, IH), 1.77 (s, 3H), 1.66 (s, 3H), 1.25 (s, 3H), 1.07 (s, 3H), 0.74 (t, J - 7.8 Hz, 9H), 0.33 (m, 6H). Example 51. 2'-Triethylsilyl-N-debenzoyl-N-benzyloxycarbonyl-7-deoxy-7β,8β-methano- 12,13-wotaxol (55) and 2'-triethylsilyl-N-debenzoyl-N-benzyloxycarbonyl-7-deoxy-Δ 6 ' 7 -12,13- wotaxol (56) A solution of N-debenzoyl-N-benzyloxycarbonyl-12,13-isσtaxol-7-O-triflate (54; 1.02 g) in ethylene dichloride (95 mL) is stirred with silica gel (35 g, EM, 40-63 μM) at 55-65°C in an oil bath for 1.5 hours. An aliquot is filtered and a TLC (5% CH 3 CN/CH 2 C1 2 ) of the filtrate shows the reaction to be complete. The reaction mixture is filtered through a medium sintered- glass funnel and acetone (600 mL) is used as a rinse. The solvent is removed under vacuum. The crude solids (1.1 g) are flash-chromatographed using 6 inches of silica gel in a 55 mm column. The elution solvent is 6% CH 3 CN/CH 2 C1 2 (750 mL), 8% (750 mL), 10% (750 mL) and 12% (750 mL) and 40 mL fractions are collected. The combined fractions are concentrated, acetone/hexane added and concentrated again to give white solids. Fractions 29-37 contain 2'-triethylsilyl-N-debenzoyl-N-benzyloxycarbonyl-7-deoxy-Δ 6,7 -12,13-wotaxol (56; 0.174 g, 18%). Η NMR spectrum is identical to the spectrum of 56 described in Example 57. Fractions 41-64 contain 2'-Triethylsilyl-N-debenzoyl-N-benzyloxycarbonyl-7-deoxy-7β,8β- methano-12,13-wøtaxol (55; 0.659 g, 67%). Tic: silica gel; 25% EtOAc/hexane; starting material Rf - 0.63, cyclopropane 55 Rf - 0.35, olefin 56 Rf - 0.43. 'H NMR (CDC1 3 , TMS), δ 8.21 (d, J - 6.6 Hz, 2H), 7.54-7.18 (m, 11H), 6.93 (m, 2H), 5.82 (d, J - 9.9 Hz, IH), 5.60 (d, J - 6.5, IH), 5.51 (d, J - 10.6 Hz, IH), 5.23 (d, J - 1.97 Hz, IH), 4.79 (s, IH), 4.67 (s, 2H), 4.63 (d, J - 1.8 Hz, IH), 4.39 (d, J - 8.6 Hz, IH), 4.13 (d, J - 8.7 Hz, IH), 2.96 (d, J - 18.6 Hz, IH), 2.75 (s, IH), 2.62 (s, 3H), 2.47 (dt, J - 16.0), 4.05 (Hz, IH), 2.17 (m, 4H, H 7 ), 2.11 (d, iH), 1.97 (d, J - 18.9 Hz), 1.73 (m, IH), 1.59 (s, 3H), 1.31 (s, 3H), 1.11 (s, 3H), 0.73 (t, J - 7.9 Hz, 9H), 0.34 (m, 6H). 13 C NMR (CDC1 3 , TMS), δ 203.7, 170.1, 169.7, 168.8, 167.1, 155.6, 141.5, 138.7, 136.1, 133.6, 130.5, 129.2, 128.7, 128.6, 128.3, 127.9, 127.4, 126.4, 122.5, 85.1, 80.5, 78.9, 78.7, 78.3, 75.6, 75.2, 66.8, 57.4, 54.9, 39.7, 36.6, 33.1, 32.3, 30.3, 29.7, 29.4, 25.9, 22.4, 21.3, 20.9, 14.1, 13.0, 6.5, 4.1. Example 52. 2'-Triethylsilyl-N-debenzoyl-7-deoxy-7β,8β-me ano-12,13-wotaxol (57) 27548- PJD-152 Ammonium formate (0.96 g) and 10% Pd/C (0.44 g) are added to a solution of 2'- triethylsilyl-N-debenzoyl-N-benzyloxycarbonyl-7-deoxy-7β,8β-methano-12,13-wotaxol (55; 1.343 g) in MeOH (18 mL) and THF (12 mL). The mixture is stiπed for 10 minutes at room temperature and then cooled to 0°C. The reaction mixture is monitored by TLC (50% EtOAc/hexane) and is complete after 2 hours of stirring. The mixture is filtered through Celite and rinsed with EtOAc (150 mL). The filtrate is washed with saturated aq. NaHCO 3 solution (100 mL). The aqueous layer is back-extracted with EtOAc and the combined organic layers are washed with saturated aq. NaCl solution. The organic layer is dried through Na^O^ the solvent removed under vacuum and the solids subjected to high vacuum, giving 2'-triethylsilyl-N- debenzoyl-7-deoxy-7β,8β-methano-12,13-wotaxol (1.114 g). Tic: silica gel; 50% EtOAc/hexane; starting material Rf - 0.64, amine 57 Rf - 0.42. 'H NMR (CDC1 3 , TMS), δ 8.09 (m, 2H), 7.65 (m, IH), 7.53 (m, 2H), 7.34 (m, 4H), 7.17 (m, IH), 5.59 (d, J = 6.65 Hz, IH), 5.19 (d, J - 1.91 Hz, IH), 4.76 (d, J - 3.1 Hz, IH), 4.4 (m, 2H), 4.30 (d, J - 5.4, IH), 4.08 (d, J - 8.6 Hz, IH), 3.81 (d, J - 6.6 Hz, IH), 2.72 (s, IH), 2.53-2.39 (m, 2H), 2.30 (s, 3H), 2.16 (s, 3H), 1.92 (d, J - 18.5 Hz, IH), 1.69 (s, 3H), 1.28 (s, 3H), 1.10 (s, 3H), 0.90 (t, J - 8.0 Hz, 9H), 0.56 (m, 6H). Example 53. 2'-Triethylsilyl-N-debenzoyl-N-(t-butyl)oxycarbonyl-7-deoxy-7β,8β-methano- 12,13-wotaxol (58) A solution of 2'-triethylsilyl-N-debenzoyl-7-deoxy-7β,8β-methano-12,13-wotaxol (57; 0.438 g), triethylamine (88 μl) and di-t-butyldicarbonate (0.125 g) in THF (10 mL) is stirred at room temperature overnight. The reaction is determined to be complete by TLC (50% EtOAc/hexane). The mixture is diluted with EtOAc (100 mL) and the resulting organic layer is washed with saturated aq. NaHCO 3 and NaCl solutions. The organic layer is dried through Na^O^ the solvent removed under vacuum and the crude solids subjected to high vacuum, giving 2'-triethylsilyl-N-debenzoyl-N-(t-butyl)oxycarbonyl-7-deoxy-7β,8β-methano-12,13- wøtaxol (0.495 g). Tic, silica gel, 50% EtOAc/hexane; starting material Rf - 0.45, 58 Rf - 0.66 'H NMR (CDC1 3 , TMS): δ 8.18 (d, J - 7.2 Hz, 2H), 7.59-7.24 (m, 8H), 5.62 (d, J - 6.8, IH), 5.55 (d, J - 10.0 Hz, IH), 5.43 (d, J - 10.0 Hz, IH), 5.24 (d, J - 2.0 Hz, IH), 4.81 (s, IH), 4.60 (s, IH), 4.42 (d, J - 8.6 Hz, IH), 4.11 (d, J - 8.6 Hz, IH), 3.88 (d, J - 6.7 Hz, IH), 2.93 (d, J - 18.5 Hz, IH), 2.76 (s, IH), 2.61 (s, 3H), 2.47 (dt, J - 4.3 and 16.0 Hz, 1H), 2.17 (m, 4H), 2.00 (d, J - 16.0 Hz, IH), 1.71 (m, IH), 1.52 (s, 3H), 1.26 (m, IH), 1.12 (s, 3H), 1.10 (s, 3H), 0.74 (t, J - 3.4, 9H), 0.34 (m, 6H). Example 54. N-Debenzoyl-N-(t-butyl)oxycarbonyl-7-deoxy-7β,8β-methano- 12,13-ώσtaxol (17) A solution of 2'-triethylsilyl-N-debenzoyl-N-(t-butyl)oxycarbonyl-7-deoxy-7β,8β- methano-12,13-wotaxol (58; 0.49 g) in CH 3 CN (2.45 mL) is treated with Et 3 N(HF) 3 (1.47 mL) and stirred at room temperature. The reaction is determined to be complete after 30 minutes by TLC (50% EtOAc/hexane). The reaction mixture is diluted with EtOAc (100 mL) and the organic layer washed with saturated aq. NaHCO 3 and NaCl solutions. The organic layer is dried through Na^O^ the solvent removed under vacuum and the crude solids are subjected to high vacuum (0.422 g). The crude solids are flash-chromatographed using 6 inches of silica gel in a 30 mm column. The elution solvent is 42.5% EtOAc/hexane (300 mL), 45% (200 mL) and 50% (200 mL) and 20 mL fractions are collected. Fractions 9-14 contained 0.308 g (71%) of N-debenzoyl-N-(t-butyl)oxycarbonyl-7-deoxy-7β,8β-methano-12,13-wotaxol. Tic: silica gel; 50% EtOAc/hexane; starting material Rf - 0.70, 17 Rf = 0.47. Η NMR (CDC1 3 , TMS): δ 8.19 (d, J - 7.3 Hz, 2H), 7.61-7.29 (m, 8H), 5.62 (d, J - 6.7 Hz, IH), 5.42 (m, 2H), 5.22 (d, J - 2.0 Hz, IH), 4.79 (d, J - 3.2 Hz, IH), 4.69 (d, J - 3.4 Hz, IH), 4.42 (d, J - 8.6 Hz, IH), 4.09 (d, J - 8.6, IH), 3.87 (d, J - 6.7 Hz, IH), 3.24 (d, J - 4.4 Hz, IH), 2.96 (d, J - 19.1 Hz, IH), 2.75 (s, IH), 2.56 (s, 3H), 2.45 (dt, J - 4.3 and 16.1 Hz, IH), 2.17 (m, 5H), 2.10 (d, J - 16.0 Hz, IH), 1.69 (m, 4H), 1.58 (s, 3H), 1.33 (m, 4H), 1.13 (s, 9H). 13 C NMR (CDC1 3 , TMS), δ 203.5, 171.0, 170.1, 169.7, 167.3, 155.0, 141.8, 138.8, 133.6, 130.4, 129.1, 128.8, 128.7, 128.0, 126.5, 122.6, 85.2, 80.4, 80.0, 78.9, 78.6, 78.4, 75.7, 73.7, 55.6, 55.0, 39.8, 36.7, 32.9, 32.4, 30.1, 29.0, 28.0, 25.8, 22.4, 21.1, 20.9, 14.2, 12.9. mass spectrum 832.3538 + H requires 832.3544), 986, 832, 776, 758, 732, 551, 387, 180, 105, 77, 57, 43 m/z. Example 55. 2'-Triethylsilyl-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7β,8β-methano- 12,13-irøtaxol (59) (( {2aR-[2aα,4β,4aβ,6β,7α,9,(αK^βS * ),llα,12α,12aα,12bα] β-[(t- butyl)aminocarbonylamino] -α-triethylsilyloxybenzenepropanoic acid, 6, 12b-bis(acetyloxy)- 12- (benzoyloxy)-2a,3,4,4a,5,6,7,10,ll,12,12a,12b-dodecahydro-ll-hydroxy-8,13,13-trimethyl-5-oxo- 4,4a;7,ll-bismethano-lH-cyclodeca[3,4]benz[l,2-b]-oxet-9-yl Ester )) A solution of crude 2'-triethylsilyl-N-debenzoyl-7-deoxy-7β,8β-methano-12,13-wotaxol (57; 1.11 g) and t-butylisocyanate (0.6 mL, 5.25 mmols) in THF (15 mL) and E^N (18 μL) is stirred overnight at rt. The solvent is removed under reduced pressure and the residue placed under high vacuum. 2'-Triethylsilyl-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7β,8β- methano-12,13-wøtaxol (59; 1.225 g) is obtained: 'H NMR (CDC1 3 , TMS) δ 8.18 (d, 2H, J - 6.8 Hz), 7.57 (t, IH), 7.49 (m, 2H), 7.35 (m, 2H), 7.27 (m, 3H), 5.64 (d, IH, J - 6.6Hz), 5.56 (d, IH, J - 9.3 Hz), 5.23 (d, IH , J - 1.9 Hz), 5.18 (d, IH, J - 9.2 Hz), 4.82 (s, IH), 4.60 (d, IH, J - 1.9 Hz), 4.42 (d, IH, J - 8.7 Hz), 4.12 (d, IH, J - 8.5 Hz), 3.90 (d, IH, J - 6.6 Hz), 2.95 (d, IH, J - 19.5 Hz), 2.76 (s, IH), 2.64 (s, 3H), 2.44 (dt, IH, J - 16.2 Hz), 2.17 (s, 3H), 2.16 (m, 2H), 2.1 l(d, IH, J - 16.0 Hz), 1.34 (s, 3H), 1.13 (s, 3H), 1.00 (s, 9H), 0.74 (t, 9H), 0.30 (m, 6H). Example 56. N-Debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7β,8β-methano-12,13-isotaxol (36) (( {2ai?-[2aα,4β,4aβ,6β,7α,9,(αK * ,βS * ),l lα,12α,12aα,12bα] }-β-[(t- Butyl)aminocarbonylamino]-α-hydroxybenzenepropanoic acid, 6,12b-Bis(acetyloxy)-12- (benzoyloxy)-2a,3,4,4a,5,6,7,10,l l,12,12a,12b-dodecahydro-l l-hydroxy-8,13,13-trimethyl-5-oxo- 4,4a;7,ll-bismethano-lH-cyclodeca[3,4]benz[l,2-b]-oxet-9-yl Ester )) Using the procedure described for the preparation of 17, a solution of crude 2'-triethylsilyl-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7β,8β-methano-12,13-wotaxol (59; 1.225 g) and triethylamine trihydrofluoride (3.66 mL) in CH 3 CN (6 mL) is prepared at O°C, then allowed to warm to rt while stirring for 1 hr. Following workup and flash chromatography over silica gel, N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-7β,8β-methano-12,13-wotaxol (36; 0.919 g, 1.10 mmols; 81% from 55) is obtained: IH NMR (CDC1 3 , TMS) δ 8.17 (d, 2H, J - 7.0 Hz), 7.59 (t, IH, J - 7.3 Hz), 7.50 (t, 2H, J - 7.6 Hz), 7.36 (m, 4H), 7.29 (m, IH), 5.62 (d, IH, J - 6.5 Hz), 5.48 (dd, IH, J - 2.7, 9.2 Hz), 5.26 (d, IH, J - 9.2 Hz), 5.20 (d, IH, J - 1.9 Hz), 4.77 (m, IH), 4.69 (m, IH), 4.41 (d, IH), 4.09 (d, IH, J - 8.6 Hz), 3.85 (d, IH, J - 6.6 Hz), 2.91 (d, IH, J - 19.0 Hz), 2.72 (s, IH), 2.53 (s, 3H), 2.40 (dt, IH, J - 16.1 Hz), 2.16 (s, 3H), 2.11 (m, 2H), 2.07 (d, IH, J - 16.1 Hz), 1.71 (t, IH, J - 6.1 Hz), 1.54 (s, 3H), 1.30 (s, 3H), 1.30 (m, IH), 1.11 (s, 3H), 1.04 (s, 9H). 13 C NMR (CDC1 3 , TMS) δ 203.6, 171.0, 170.4, 169.8, 167.3, 156.2, 141.8, 139.2, 133.6, 130.4, 129.0, 128.78, 128.76, 127.8, 126.6, 122.4, 85.2, 80.5, 78.9, 78.4, 78.3, 75.7, 74.4, 55.2, 55.0, 50.4, 39.7, 36.7, 32.8, 32.5, 30.1, 29.2, 28.8, 25.8, 22.4, 21.1, 20.9, 14.2, 12.8. mass spectrum (FAB), found: 831.3701 (C 45 Hj 4 N 2 O 13 + H requires 831.37.04), 732, 263, 235, 205, 179, 136, 119, 106, 105, 57 m/z. Example 57. 2'-Triethylsilyl-N-debenzoyl-N-benzyloxycarbonyl-7-deoxy-Δ 6,7 -12,13-wotaxol (56) A solution of N-debenzoyl-N-benzyloxycarbonyl-12,13-wotaxol-7-O-triflate (54; 2.348 g) and DBU (3.11 mL) in toluene (180 mL) is heated with a 60°C oil bath for 4 hours. A trace of starting material is noted by TLC (5% CH 3 CN/CH 2 C1 2 ). The reaction mixture is diluted with EtOAc (100 mL) and the resulting organic layer is washed with saturated aq. CuSO 4 solution, water, saturated aq. NaHCO 3 and NaCl solutions. The organic layer is dried through Na 2 SO 4 and the solvent removed under vacuum. The crude solids (2.07 g) are flash-chromatographed using 6 inches of silica gel in a 55 mm column. The elution solvent is 4% CH 3 CN/CH 2 C1 2 (1000 mL), 5% (1000 mL), 6% (1000 mL), 8% (1000 mL) and 15% (1000 mL) and 40 mL fractions are collected. Fractions 27-74 contained 2'-triethylsilyl-N-debenzoyl-N- benzyloxycarbonyl-7-deoxy-Δ 6 ' 7 -12,13-wotaxol (56; 1.43 g, 68%) as a white solid. Tic: silica gel; 5% CH 3 CN/CH 2 C1 2 ; starting material Rf = 0.64, olefin 56 Rf = 0.47, cyclopropane 55 Rf - 0.36. Η NMR (CDC1 3 , TMS), δ 8.21 (d, J - 7.1 Hz, 2H), 7.60-7.47 (m, 3H), 7.41-7.26 (m, 6H), 7.19-7.13 (2H), 6.97 (m, 2H), 6.09 (dd, J - 5.3 and 9.9 Hz, IH), 6.02 (d, J - 9.8, IH), 5.82 (d, J - 9.8, IH), 5.72 (d, J - 5.8 Hz, IH), 5.51 (d, J - 10.3, IH), 5.18 (s, IH), 5.12 (d, J - 5.3 Hz, IH), 4.83 (d, J - 12.5 Hz, IH), 4.76 (d, J - 12.4, IH), 4.64 (d, J - 1.8, IH), 4.52 (d, J - 8.4, IH), 4.37 (d, J - 8.3 Hz, IH), 3.67 (d, J = 5.6 Hz, IH), 2.95 (d, J - 18.6 Hz, IH), 2.75 (s, IH), 2.67 (s, 3H), 2.18 (s, 3H), 1.90 (d, J - 18.5 Hz, IH), 1.76 (s, 3H), 1.53 (s, 3H), 1.28 (s, 3H), 1.03 (s, 3H), 0.73 (t, J - 8.0, 9H), 0.35 (m, 6H). 13 C NMR (CDC1 3 , TMS), δ 207.7, 169.9, 169.6, 168.8, 166.7, 155.7, 142.2, 138.8, 138.6, 136.1, 133.7, 130.3, 129.2, 128.7, 128.6, 128.4, 127.9, 127.9, 127.4, 126.4, 125.6, 122.1, 81.2, 80.8, 79.1, 77, 75.0, 73.7, 66.8, 57.3, 56.0, 54.1, 39.6, 36.5, 32.6, 29.9, 23.3, 21.0, 20.8, 18.5, 14.1, 6.4, 4.1. Fractions 82-90 contained 2'-triethylsilyl-N-debenzoyl-N-benzyloxycarbonyl-7-deoxy-7β,8β- methano-12,13-wotaxol (55; 0.14 g, 7%). 'H NMR spectrum is identical to the spectrum of 55 described in Example 51. Example 58. 2'-Triethylsilyl-N-debenzoyl-7-deoxy-Δ 6,7 -12,13-wotaxol (60) (( {2aR-[2aα, 4aβ,6β,7α,9,(α^,βS .llαΛ2α,12aα,12bα^β-amino-α- triethylsilyloxybenzenepropanoic acid, 6,12b-bis(acetyloxy)-12-(benzoyloxy)- 2a,4a,5,6,7,10,l l,12,12a,12b-decahydro-l l-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,l 1-methano- lH-cyclodeca[3,4]benz[l,2-b]-oxet-9-yl Ester )) Using the procedure described for the preparation of 57, a solution of 2'-triethylsilyl-N- debenzoyl-N-benzyloxycarbonyl-7-deoxy-Δ 6,7 -12,13-wotaxol (56; 1.721 g, 1.75 mmols) and ammonium formate (1.07 g, 16.97 mmols) in MeOH (23 mL) and THF (12.6 mL) is stirred at rt with 10% palladium on carbon for 10 min and then at 0°C for one hr. Following workup, 2'- triethylsilyl-N-debenzoyl-7-deoxy-Δ 6,7 -12,13-wotaxol (60; 1.47 g) is obtained. 1 H NMR (CDC1 3 , TMS ) δ 8.11 (d, 2H, J = 8.0 Hz), 7.67 (t, IH, J - 7.4 Hz), 7.54 (t, 2H), 7.35 (m, 4H), 7.18 (m, IH), 6.05 (m, 2H), 5.68 (d, IH, J - 5.1 Hz), 5.13 (s, IH), 5.10 (d, IH, J - 4.5 Hz), 4.51 (d, IH, J - 8.2 Hz), 4.32 (m, 3H), 3.62 (d, IH, J - 5.3 Hz), 2.71 (s, IH), 2.45 (d, IH, J - 17.9 Hz), 2.30 (s, 3H), 2.17 (s, 3H), 1.83 (d, IH, J -17.9 Hz), 1.69 (s, 3H), 1.44 (s, 3H), 1.27 (s, 3H), 1.02 (s, 3H), 0.91 (t, 9H), 0.56 (m, 6H). Example 59. 2 , -Triethylsilyl-N-debenzoyl-N-(t-butyl)oxycarbonyl-7-deoxy-Δ 6,7 -12,13-wotaxol (61); (( {2aK-[2aα, 4aβ,6β,7α,9,(αΛ * ,β5 * ),llα,12α,12aα,12bα]}-β-t(t-Butyl)oxy- carbonylamino] -α-hydroxybenzenepropanoic acid, 6,12b-bis(acetyloxy)- 12-(benzoyloxy)- 2a,4a,5,6,7,10,l l,12,12a,12b-decahydro-l l-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,l 1-methano- lH-cyclodeca[3,4]benz[l,2-b]-oxet-9-yl Ester )) Using the procedure described for the preparation of 58, a solution of crude 2'- triethylsilyl-N-debenzoyl-7-deoxy-Δ 6,7 -12,13-ύotaxol (60; 0.515 g) and di-t-butyl dicarbonate ("BOC anhydride," 0.147 g, 0.675 mmole) in THF (12 mL) and E^N (0.10 mL) is stirred overnight at RT. Additional di-t-butyl carbonate (0.013 g, 0.059 mmole) is added and the solution st red another 2 hr. Following workup, 2'-triethylsilyl-N-debenzoyl-N-(t- butyl)oxycarbonyl-7-deoxy-Δ 6,7 -12,13-wotaxol (61; 0.546 g) is obtained. 'H NMR (CDC1 3 , TMS) δ 8.17 (d, 2H, J - 7.3 Hz), 7.58 (t, IH, J - 7.4 Hz), 7.49 (t, 2H), 7.38 (m, 2H), 7.27 (m, 3H), 6.10 (dd, IH, J - 5.2, 9.9 Hz), 6.04 (d, IH, J - 9.8 Hz), 5.73 (d, IH, J - 4.3 Hz), 5.55 (d, IH, J - 10.0 Hz), 5.44 (d, IH, J - 10.5 Hz), 5.19 (s, IH), 5.14 (d, IH, J - 5.1 Hz), 4.62 (s, IH), 4.55 (d, IH, J - 8.1 Hz), 4.35 (d, IH, J - 8.3 Hz), 3.69 (d, IH, J - 5.4 Hz), 2.94 (d, IH, J - 18.8 Hz), 2.77 (q, IH), 2.67 (s, 3H), 2.19 (s, 3H), 2.07 (d, IH, J = 10.9 Hz), 1.76 (s, 3H), 1.28 (s, 3H), 1.16 (s, 9H), 1.05 (s, 3H), 0.74 (t, 9H), 0.37 (m, 6H). Example 60. N-Debenzoyl-N-(t-butyl)oxycarbonyl-7-deoxy-Δ 6 ' 7 -12,13-wotaxol. (18) (( {2aK-[2aα, 4aβ,6β,7α,9,(αK * ,βS * ),l lα,12α,12aα,12bα] }-β-[(t-Butyl)oxycarbonyl-amino]-α- hydroxybenzenepropanoic acid, 6,12b-bis(acetyloxy)-12-(benzoyloxy)- 2a,4a,5,6,7,10,l l,12,12a,12b-decahydro-l l-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,l 1-methano- lH-cyclodeca[3,4]benz[l,2-b]-oxet-9-yl Ester )) Using the procedure described for the preparation of 17, a solution of 2'-triethylsilyl-N- debenzoyl-N-(t-butyl)oxycarbonyl-7-deoxy-Δ 6,7 -12,13-«øtaxol (61, 0.546 g) from the preceding experiment and triethylamine trihydrofluoride (1.64 mL) in CH 3 CN (2.7 mL) is stirred at 0 - 25°C for 1 hr. Following workup and chromatographic purification over flash silica gel, N- debenzoyl-N-(t-butyl)oxycarbonyl-7-deoxy-Δ 6,7 -12,13-wotaxol (18; 0.445 g, 0.547 mmole, 87% from 56) is obtained. Η NMR (CDC1 3 , TMS) δ 8.18 (d, 2H, J - 7.2 Hz), 7.61 (t, IH, J - 7.3 Hz), 7.50 (t, 2H), 7.35 (m, 5H), 6.09 (dd, IH, J - 5.1, 9.9 Hz), 6.04 (d, IH, J - 9.8 Hz), 5.73 (d, IH, J - 5.5 Hz), 5.40 (s, 2H), 5.18 (s, IH), 5.13 (d, IH, J - 5.1 Hz), 4.70 (s, IH), 4.55( d, IH, J - 8.3 Hz), 4.34 (d, IH, J - 8.4 Hz), 3.68 (d, IH, J - 5.4 Hz), 2.97 (d, IH, J - 18.9 Hz), 2.74 (s, IH), 2.61 (s, 3H), 2.20 (s, 3H), 2.09 (d, IH, J - 18.0 Hz), 1.75 (s, 3H), 1.53 (s, 3H), 1.32 (s, 3H), 1.20 (s, 9H), 1.05 (s, 3H). mass spectrum (FAB), found 832.3538 (C 45 Hj 3 NOι 4 + H requires 832.3544), 776, 732, 180, 150, 105, 57 m/z. Example 61. 2' -Triethylsilyl-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 6,7 - 12,13-wotaxol (62) (( {2aR-[2aα, 4aβ,6β,7α,9,((xR^β5 * ),llα,12α,12aα,12bα] β-[(t- Butyl)aminocarbonylamino]-a-triethylsilyloxybenzenepropanoic acid, 6,12b-bis(acetyloxy)-12- (benzoyloxy)-2a,4a,5,6,7,10,ll,12,12a,12b-decahydro-ll-hydroxy-4a,8,13,13-tetramethyl-5-oxo- 7,ll-methano-lH-cyclodeca[3,4]benz[l,2-b]-oxet-9-yl Ester )) Using the procedure described for the preparation of 59, a solution of 2'-triethylsilyl-N- debenzoyl-7-deoxy-Δ 6,7 -12,13-ijotaxol (60; 0.956 g) and t-butylisocyanate (0.52 mL, 4.52 mmols) in THF (19 mL) and E^N (16 μL) is prepared at ice bath temperature and then allowed to warm and stir at rt overnight. Following workup, 2'-triethylsilyl-N-debenzoyl-N-(t- butyl)aminocarbonyl-7-deoxy-Δ 6,7 -12,13-wøtaxol (62; 1.027 g) is obtained. Η NMR (CDC1 3 ,TMS) δ 8.17 (d, 2H, J - 7.0 Hz), 7.59 (t, IH, J - 7.3 Hz), 7.50 (t, 2H), 7.35 (m, 2H), 7.26 (m, 3H), 6.08 (m, 2H), 5.73 (d, IH, J - 5.4 Hz), 5.51 (d, IH, J - 8.9 Hz), 5.18 (m, 3H), 4.60 (d, IH, J - 1.1 Hz), 4.55 (d, IH), 4.37 (d, IH, J - 8.3 Hz), 3.70 (d, IH, J - 5.3 Hz), 2.95 (d, IH, J - 19.0 Hz), 2.76 (s, IH), 2.70 (s, 3H), 2.19 (s, 3H), 2.11 (d, IH, J - 20.5 Hz), 1.76 (s, 3H), 1.55 (s, 3H), 1.32 (s, 3H), 1.07 (s, 9H), 1.06 (s, 3H), 0.73 (t, 9H), 0.30 (m, 6H). Example 62. N-Debenzoyl-N-(t-butyl)ami_nocarbonyl-7-deoxy-Δ 6,7 -12,13-isotaxol. (38) (( <2aR-[2aα, 4aβ,6β,7α,9,(αR * ,βS * ),l lα,12α,12aα,12bα] }-β-[(t-Butyl)amino-carbonylamino]- α-hydroxybenzenepropanoic acid, 6,12b-bis(acetyloxy)-12-(benzoyloxy)- 2a,4a,5,6,7,10,l l,12,12a,12b-decahydro-l l-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,l 1-methano- lH-cyclodeca[3,4]benz[l,2-b]-oxet-9-yl Ester )) Using the procedure described for the preparation of 17, a solution of crude 2'-triethylsilyl-N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 6 ' 7 -12,13-wotaxol (62; 1.02 g) and Et 3 N HF) 3 in CH 3 CN (5 mL) is prepared at 0°C and then stirred while allowing to warm to rt for 1 hr. Following workup and flash chromatography over silica gel, N-debenzoyl-N-(t-butyl)aminocarbonyl-7-deoxy-Δ 6,7 -12,13-isotaxol (38; 0.842 g, 1.01 mmols, 91% yield from 56) is obtained. Η NMR (CDC1 3 , TMS) δ 8.16 (d, 2H, J = 7.1 Hz), 7.60 (t, IH, J = 7.3 Hz), 7.50 (r, 2H), 7.35 (m, 4H), 7.30 (m, IH), 6.05 (m, 2H), 5.71 (d, IH, J - 5.2 Hz), 5.46 (dd, IH, J = 2.5, 9.1 Hz), 5.39 (d, IH, J - 9.2 Hz), 5.12 (m, 2H), 4.69 (dd, IH, J - 2.5, 5.1 Hz), 4.53 (d, IH), 4.33 (d, IH, J - 8.2 Hz), 3.77 (d, IH, J - 5.5 Hz), 3.65 (d, IH, J - 5.3 Hz), 2.92 (d, IH, J - 18.7 Hz), 2.71 (s, IH), 2.58 (s, 3H), 2.19 (s, 3H), 2.10 (d, IH, J - 18.3 Hz), 1.74 (s, 3H), 1.47 (s, 3H), 1.30 (s, 3H), 1.10 (s, 9H), 1.04 (s, 3H); 13 C NMR (CDC1 3 , TMS) δ 206.7, 172.0, 171.3, 170.7, 166.6, 156.5, 143.3, 138.9, 133.7, 130.2, 128.9, 128.8, 127.9, 126.7, 121.7, 84.5, 81.1, 77.7, 77.6, 77.2, 74.7, 73.5, 71.7, 57.9, 55.7, 50.5, 39.5, 38.7, 35.3, 32.9, 29.8, 29.3, 23.2, 21.0, 19.8, 14.4, 9.1. mass spectrum (FAB), found: 831.3701 (C 4 jH 54 N 2 O 13 requires 831.3704), 732, 263, 235, 205, 136, 106, 105, 57 m/z. Example 63 Preparation of (O-methoxymethyl)-13-(N-Cbz-2 -TES-β-phenyl isoserinyl)-Δ 12,13 - iso-baccatin HI (63) Following the procedure of Example 45 but using as starting material 13-(N-Cbz-2-TES-β-phenyl isoserinyl)-Δ I2,13 -iso-baccatin IH (53) and chloromethyl methyl ether in place of chloromethyl ethyl ether is prepared (O-methoxymethyl)-13-(N-Cbz-2 ' -OTES-β- phenyl isoserinyl)-Δ 12,13 -iso-baccatin IH (63) Example 64 Preparation of 7-(O-methoxymethyl)-13-(N-Cbz-β-phenyl isoserinyl)-Δ 12,13 -iso- baccatin HI (64) Following the procedure of Example 43 but using as starting material (O-methoxy- methyl)- 13-(N-Cbz-2 ' -TES-β-phenyl isoserinyl)-Δ 12 ' 13 -iso-baccatin m (63) in place of 7-(O- ethoxymethyl)-13-(N-Boc-2 ' -TES-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin in is prepared 7-(O-methoxymethyl)-13-(N-Cbz-β-phenyl isoserinyl)-Δ 12,I3 -iso-baccatin HI (64). Example 65 Preparation of 7-(O-methoxymethyl)-13-(β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin HI (65) 7-(O-Methoxymethyl)-13-(N-Cbz-β-phenyl isoserinyl)-Δ 12 ' 13 -iso-baccatin HI (64, 450 mg, 0.485mM) is stirred at RT under nitrogen in methanol (7.5 mL) and dry THF (5 mL). To this solution is added ammonium formate (225 mg) and 10% Pd C (125 mg). The reaction is allowed to react at RT for 10 min and then cooled in ice bath, following the reaction by HPLC while maintaining the temperature at 0° C. After a total of 55 minutes reaction time, the catalyst is filtered off and the filtrate diluted with ethyl acetate. The organic solution is washed with 5% sodium bicarbonate, dried over sodium sulfate and evaporated under vacuum, reevaporating the residue twice with ethyl acetate-toluene leaving 7-(O-methoxymethyl)-13-(β-phenyl isoserinyl)- Δ I2 I3 -iso-baccatin m (65). TLC: silica gel; 40-60 ethyl acetate-hexane; Rf: origin Proton NMR (CDC1 3 ; TMS): δ 1.09 (s, 3H); 1.25 (s, 3H); 1.61 (s, 3H); 1.66 (s, 3H); 2.16 (s, 3H); 2.18 (s, 3H); 3.25 (s, 3H); 3.76-3.83 (d, IH); 3.93-4.05 (dd IH); 4.20- 4.40 (m, 4H); 4.45-4.54(d, IH); 4.62-4.72 (d, IH); 4.80-4.90 (dd, IH); 5.44-5.53 (d, IH); 5.73 (s, IH); 7.26-7.40 (m, 5H); 7.45-7.55 (t, 2H); 7.57-7.67 (t, IH); 7.99-8.09 (d, 2H). Example 66 Preparation of 7-(O-methoxymethyl)-13-(N-Boc-β-phenyl isoserinyl)- Δ^ so-baccatin III (66) 7-(O-Methoxymethyl)-13-(β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (65, 0.194 mM) is stirred at RT under nitrogen in dry THF (1 mL) and the solution treated with di-tert-butyl dicarbonate (43 g, 0.197 mM) in dry THF (0.4 L), followed by triethylamine (0.26 mL). The reaction is followed by HPLC and after 3.5 hours additional di-t-butyl dicarbonate (5 mg) is added. After 5.5 hours reaction the solvent is evaporated under vacuum. The crude product is purified by HPLC over a size B E. Merck prepacked silica gel column, eluting with (50-50) ethyl acetate- hexane. Fractions of 7 mL are collected, analyzing them by TLC. Fractions 39-46 are found to contained pure product and are combined and evaporated under vacuum to give 7-(O-methoxymethyl)-13-(N-Boc-β-phenyl isoserinyD-Δ^-iso-baccatin III (66, 71% yield) as a white solid. TLC: silica gel; 60-40 ethyl acetate-hexane; Rf: 0.69 Proton NMR (CDC1 3 ; TMS): δ 1.11 (s, 3H); 1.24 (s, 9H); 1.27 (s, 3H); 1.62 (s, 3H); 1.69 (s, 3H); 1.87-2.15 (m, 3H); 2.17 (s, 3H); 2.56 (s, 3H); 2.62 (s, IH); 2.76-2.94 (m, 2H); 3.26 (s, 3H); 3.42-3.50 (d, IH); 3.82-3.89 (d, IH); 3.98-4.10 (dd, IH); 4.24- 4.33 (d, IH); 4.36-4.44 (d, IH); 4.46-4.54 (d, IH); 4.63-4.73 (d+s, 2H); 4.85-4.93 (dd, 1H); 5.34-5.45 (d, IH); 5.50-5.59 (m, 2H); 5.77 (s, IH); 7.27-7.43 (m, 5H); 7.43-7.53 (t, 2H); 7.54-7.63 (t, IH); 8.04-8.16 (d, 2H). Example 67 Preparation of 7-(O-methoxymethyl)-13-(N-t-butylaminocarbonyl-β- phenyl III (67) 7-(O-Methoxymethyl)-13-(β-phenyl isoserinyD-Δ^'^-iso-baccatin III (65, 0.485 mM) is stirred at 0° C under nitrogen in dry THF (5 mL) and the solution treated with t-butylisocyanate (75 mL). After 5 minutes the reaction is allowed to warm to RT. The reaction is followed by HPLC and allowed to stand overnight. After 18 hr the solvent is evaporated under vacuum. The crude product is purified by silica gel chromatography, eluting with a gradient of (50-50) to (60-40) ethyl acetate-hexane. Fractions of 15 mL are collected, analyzing them by TLC. Fractions 44-66 are found to contained pure product and are combined and evaporated under vacuum to give 7- (O-methoxymethyl)-13-(N-t-butylaminocarbonyl-β-phenyl isoserinyl)-Δ 12,13 -iso- baccatin III (67, 85% yield) as a white solid. TLC: silica gel; (50-50) ethyl acetate-hexane; Rf: 0.33 Proton NMR (CDC1 3 ; TMS): δ 1.11 (s, 3H); 1.14 (s, 9H); 1.25 (s, 3H); 1.59 (s, 3H); 1.69 (s, 3H); 1.88-2.15 (m, 3H); 2.17 (s, 3H); 2.56 (s, 3H); 2.60 (s, IH); 2.77-2.93 (m, 2H); 3.26 (s, 3H); 3.70-3.76 (d, IH); 3.83-3.90 (d, IH); 3.97-4.06 (dd, IH); 4.24- 4.32 (d, IH); 4.36-4.44 (d, IH); 4.44-4.54 (d+s, 2H); 4.65-4.73 (d+s, 2H); 4.86-4.94 (dd, IH); 5.19-5.26 (d, IH); 5.44-5.51 (dd, IH); 5.51-5.56 (d, IH); 5.76 (s, IH); 7.27-7.43 (m, 5H); 7.44-7.55 (t, 2H); 7.55-7.63 (t, IH); 8.07-8.14 (d, 2H). Example 68 Preparation of 7-(O-ethoxymethyl)-13-(N-Cbz-2'-TES-β-phenyl isoserinyD-Δ^'^-iso-baccatin III (68) Following the procedure of Example 42 but using as starting material 13-(N- Cbz-2'-TES-β-phenyl isoserinyl)-Δ 1 ,13 -iso-baccatin III (53) in place of 13-(N-Boc-2- TES-β-phenyl III (46) is prepared 7-(O-ethoxymethyl)- 13-(N-Cbz-2'-TES-β-phenyl isoserinyD-Δ^'^-iso-baccatin III (68) Example 69 Preparation of 7-(O-ethoxymethyl)-13-(N-Cbz-β-phenyl isoserinyl)-Δ 12,13 - iso-baccatin III (69) Following the procedure of Example 43 but using as starting material 7-(O- ethoxymethyl)-13-(N-Cbz-2'-TES-β-phenyl isoserinyl)-Δ 12 ' 13 -iso-baccatin III (68) in place of 7-(O-ethoxymethyl)-13-(N-Boc-2 ' -TES-β-phenyl III (47) is prepared 7-(O-ethoxymethyl)-13-(N-Cbz-β-phenyl isoserinyl)-Δ 12,13 -iso- baccatin III (69). Example 70 Preparation of 7-(O-ethoxymethyl)-13-(β-phenyl isoserinyl)-Δ 12 ' 13 -iso- baccatin III (70) 7-(O-Ethoxymethyl)-13-(N-Cbz-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (69, 99 mg, 0.105 mM) is stirred at RT under nitrogen in methanol (2 mL) and dry THF (1 mL). To this solution is added ammonium formate (50 mg) and 10% Pd/C (30 mg). The mixture is allowed to react at RT for 10 minutes and then cooled in ice bath, following the reaction by HPLC. After a total of 35 minutes reaction time, the catalyst is filtered off. The reaction mixture is diluted with ethyl acetate, washed with 5% sodium bicarbonate, dried over sodium sulfate and evaporated under vacuum. The residue is reevaporated twice with ethyl acetate-toluene leaving 7-(O- ethoxymethyl)-13-(β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (70). HPLC: Versapack C 18 ; 229 nm; lml/min.; (25-75-.2) water-acetonitrile-TFA; retention time: 3.80 minutes. Proton NMR (CDC1 3 ; TMS): δ 1.07-1.18 (t+s, 6H); 1.26 (s, 3H); 1.63 (s, 3H); 1.66 (s, 3H); 1.34-2.00 (m, IH); 2.00-2.15 (d, IH); 2.17 (s, 3H); 2.22 (s, 3H); 2.80-2.94 (m, IH); 3.26-3.40 (m, IH); 3.59-3.70 ( , IH); 3.79-3.86 (d, IH); 3.94-4.07 (dd IH); 4.22-4.44 (m, 3H); 4.56-4.64 (d, IH); 4.64-4.74 (d, IH); 4.83-4.94 (d, IH); 5.44-5.54 (d, IH); 5.74 (s, IH); 7.23-7.47 (m, 5H); 7.47-7.59 (t, 2H); 7.59-7.70 (t, IH); 8.00-8.10 (d, 2H). Example 71 Preparation of 7-(O-ethoxymethyl)-13-(N-Boc-β-phenyl isoserinyl)-Δ 12 13 - iso-baccatin III (41) 7-(O-Ethoxymethyl)-13-(β-phenyl isoserinyD-Δ^-iso-baccatin III (70, 0.531 mM) is stirred at RT under nitrogen in dry THF (3 mL) and the solution treated with di-tert-butyl dicarbonate (116 mg) in dry THF (1 mL), followed by triethylamine (0.076 mL). The reaction is followed by HPLC and after 2 hours additional di-t-butyl dicarbonate (15 mg) is added. After 4.5 hours reaction time, methanol (0.05 L) is added. The solvent is evaporated under vacuum and the residue twice reevaporated with methylene chloride-hexane. The crude product is purified by HPLC over a size B E. Merck prepacked silica gel column, eluting with (30-70) acetone-hexane. Fractions of 15 mL are collected, analyzing them by TLC. Fractions 18-22 are found to contained pure product and were combined and evaporated under vacuum to give 7-(O-ethoxymethyl)-13-(N-Boc-β-phenyl isoserinyl)- Δ^-iso-baccatin III (41, 82 %) as a white solid. TLC: silica gel; 30-70 acetone-hexane; Rf: 0.33 Proton NMR (CDC1 3 ; TMS): δ 1.09-1.17 (t, 3H); 1.24 (s, 9H); 1.27 (s, 3H); 1.62 (s, 3H); 1.68 (s, 3H); 1.90-2.02 (t, IH); 2.02-2.14 (d, IH); 2.17 (s, 3H); 2.18 (s, 3H); 2.57 (s, 3H); 2.62 (s, IH); 2.80-2.98 (m, 2H); 3.30-3.40 (m, IH); 3.62-3.73 (m, IH); 3.84-3.90 (d, IH); 4.00-4.10 (dd, IH); 4.26-4.34 (d, IH); 4.38-4.45 (d, IH); 4.57- 4.64 (d, IH); 4.65-4.74 (m 2H); 4.87-4.95 (d, IH); 5.35-5.49 (m, 2H); 5.50-5.57 (d, IH); 5.77 (s, IH); 7.30-7.44 (m, 5H); 7.44-7.53 (t, 2H); 7.55-7.64 (t, IH); 8.07-8.18 (d, 2H). Example 72 Preparation of 7-(O-ethoxymethyl)-13-(N-t-butylaminocarbonyl-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (43) 7-(O-Ethoxymethyl)-13-(β-phenyl isoserinyl)-Δ 12 ' 13 -iso-baccatin III (70, 0.105 mM) is stirred at 0°C under nitrogen in dry THF (1 mL) and the solution treated with t-butylisocyanate (20 μL). After 5 minutes the reaction is left to warm to RT. The reaction is followed by HPLC and allowed to proceed for 50 min. The solvent is then evaporated under vacuum and the residue purified by silica gel chromatography, eluting with (30-70) acetone-hexane. Fractions of 7 mL are collected, analyzing them by TLC. Fractions 50-67 are found to contain pure product and are combined and evaporated under vacuum to give 7-(O-ethoxymethyl)- 13-(N-t-butylaminocarbonyl-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (43, 74%) as a white solid. TLC: silica gel; (30-70) acetone-hexane; Rf: 0.22 Proton NMR (CDC1 3 ; TMS): δ 1.04-1.18 (m, 15H); 1.23 (s, 3H); 1.57 (s, 3H); 1.67 (s, 3H); 1.86-2.00 (t, IH); 2.00-2.13 (d, IH); 2.15 (s, 3H); 2.53 (s, 3H); 2.58 (s, IH); 2.73-2.93 (m, 2H); 3.26-3.39 (m, IH); 3.58-3.70 (m, IH); 3.82-3.89 (d, IH); 3.96- 4.05 (dd, IH); 4.21-4.30 (d, IH); 4.34-4.43 (d, IH); 4.55-4.64 (d, IH); 4.64-4.73 (m, 2H); 4.84-4.94 (d, IH); 5.37-5.53 (m, 3H); 5.74 (s, IH); 7.25-7.40 (m, 5H); 7.43-7.53 (t, 2H); 7.54-7.63 (t, IH); 8.04-8.12 (d, 2H). Example 73 Preparation of 7-(O-methylthiomethyl)-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)- N-(t-butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (71a,b) Δ 12 ' 13 -Iso-baccatin III-13-(4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (33a,b, 100 mg, 0.10 mM) is stirred at 0°C under nitrogen in acetonitrile (1 mL). To this solution is added dimethyl sulfide (0.060 mL) by syringe and then four times benzoyl peroxide (25 mg each) 5 min apart. By 30 min everything dissolves and after 2 hours the reaction is complete by TLC. The reaction is partitioned between ethyl acetate-5% sodium bicarbonate. After separation of the aqueous phase the organic layer is dried over sodium sulfate and evaporated under vacuum. The residue is chromatographed over silica gel (10 g), eluting with (40-60) and (50-50) ethyl acetate-hexane. Fractions of 4 mL are collected, analyzing them by TLC. Fractions 19-40 are found to contained pure product and are combined and evaporated under vacuum to give 7-(O- methylthiomethyl)-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (71a,b, 72 mg, 68% yield) product as a white solid. TLC: silica gel; (50-50) ethyl acetate-hexane; 11^0.47. Proton NMR (CDCL 3 ; TMS): δ 1.06 (s, 3H); 1.10 (s, 9H); 1.22 (s. 3H); 1.61 (s, 3H); 1.69 (s, 3H); 2.03 (s, 3H); 2.08 (s, 3H); 2.12 (s, 3H); 3.74 (s, 3H); 3.78-3.85 (s, 3H + m, IH); 4.00-4.13 (dd, IH); 4.13-4.24 (d, IH); 4.26-4.36 (d, IH); 4.42-4.52 (d, IH); 4.52-4.61 (d, IH); 4.62 (s, IH); 4.78-4.86 (d, IH); 4.99 (s, IH); 5.42-5.50 (d, IH); 5.56-5.63 (d, IH); 5.81 (s, IH); 6.33-6.42 (d, IH); 6.44 (s, IH); 6.68 (s, IH); 7.03-7.13 (d, IH); 7.23-7.49 (m, 6H); 7.49-7.58 (t, IH); 7.93-8.03 (d, 2H). Example 74 Preparation of 7-(O-methylthiomethyl)-13-(N-t-butylaminocarbonyl-β- phenyl isoserinyD-Δ^'^-iso-baccatin III (72) 7-(O-Methylthiomethyl)-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)-N-(t- butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxylic acid ester (71a,b, 72 mg, 0.068mM) is stirred at RT under nitrogen in (80-20) acetic acid- water (5 mL). TLC after 5 hours shows the reaction to be complete. The reaction is then freeze-dried. The residue is chromatographed over silica gel (13 g), eluting with (50-50) ethyl acetate-hexane. Fractions of 4 mL are collected, analyzing them by TLC. Fractions 11-24 are found to contained 7-(O-methylthiomethyl)-13-(N-t- butylaminocarbonyl-β-phenyl isoserinyD-Δ 12 13 -iso-baccatin III (72, 57 mg, 92%) as a white solid. TLC: silica gel; 50-50 ethyl acetate-hexane; 1^:0.39. Proton NMR (CDCL 3 ; TMS): δ 1.03 (s, 3H); 1.06 (s, 9H); 1.17 (s, 3H); 1.56 (s, 3H); 1.60 (s, 3H); 1.73-1.87 (t, IH); 2.02 (s, 3H); 2.09 (s, 3H); 2.48 (s, 3H); 3.77-3.85 (d, IH); 4.00-4.10 (dd, IH); 4.16-4.24 (d, IH); 4.29-4.36 (d, IH); 4.41-4.49 (d, IH); 4.49-4.56 (d, IH); 4.57 (s, IH); 4.61 (s, IH); 4.80-4.88 (d, IH); 5.31-5.41 (s+t, 2H); 5.41-5.48 (d, IH); 5.80 (s, IH); 7.20-7.34 (m, 5H); 7.37-7.47 (t, 2H); 7.47-7.56 (t, IH); 7.99-8.06 (d, 2H). Mass Spec (FAB, m/z) (M+H) + measured at 909.3840; theory for C 47 H βl 0 14 N 2 S 1 is 909.3843; 861, 847, 831, 263, 235, 205, 136, 119, 105, 61, 57. Example 75 Preparation of 7-(O-methyl)-13-(N-t-butylaminocarbonyl-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (73) Raney Nickel (8 mL), prewashed with 5% sodium bicarbonate, water, and ethanol is stirred at 0°C under nitrogen. To this is added by syringe 7-(O- methylthiomethyl)-13-(N-t-butylaminocarbonyl-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (72, 100 mg, 0.11 mM) in absolute ethanol (10 mL). The temperature is kept at 0°C throughout the reaction and the subsequent washing process described below. The reaction is followed by TLC and allowed to proceed for 4 hr, when it judged to be complete. The Raney Nickel is then allowed to settle and the upper layer of liquid removed by suction. The residual Raney nickel is treated with THF (40 mL) and the mixture stirred for 2 minutes. After the nickel has settled the liquid is removed as above. This washing process is repeated 9 times. All the washings are combined and evaporated under vacuum, leaving 65 mg solid. The residue is chromatographed over silica gel (10 g), eluting with ethyl acetate-hexane (50-50, 100 mL) and (60-40, 200 mL). Fractions of 3 mL are collected, analyzing them by TLC. Fractions 13-18 are found to contain recovered starting material, fractions 19-28 contain 7-(O-methyl)- 13-(N-t-butylaminocarbonyl-β-phenyl isoserinyl)-Δ 12,13 -iso- baccatin III (73, 43 mg, 43%) as a white solid. TLC: silica gel; (50-50) ethyl acetate-hexane; 1^:0.33. Proton NMR (CDCL 3 ; TMS): δ 1.03 (s, 3H); 1.06 (s, 9H); 1.17 (s, 3H); 1.52 (s, 3H); 1.56 (s, 3H); 1.90-2.05 (d, 2H); 2.10 (s, 3H); 2.48 (s, 3H); 2.56-2.68 (m, 1H);2.68- 2.83 (d, 2H); 3.13 (s, 3H); 3.69-3.82 (m, 2H); 4.14-4.24 (d, IH); 4.27-4.36 (d, IH); 4.55 (s, IH); 4.61 (s, IH); 4.80-4.91 (d, IH); 5.25-5.43 (t, 2H); 5.43-5.49 (d, IH); 5.76 (s, IH); 7.16-7.35 (m, 5H); 7.35-7.46 (t, 2H); 7.46-7.57 (t, IH); 7.96-8.07 (d, 2H). Mass Spec (FAB, m/z) (M+H) + measured at 863.3981; theory for is 863.3966; 563, 263, 235, 205, 179, 136, 119, 106, 105, 58, 57, 43. Example 76 Preparation of Δ^-iso-baccatin III-13-(4S,5R)-N-Cbz-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (74a,b) 7-TES-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)-N-Cbz-2-(2,4-dimethoxyphenyl)-4- phenyl-5-oxazolidinecarboxylic acid ester (51a,b, 215 mg, 0.188mM) is stirred at RT under nitrogen in acetonitrile (0.75 mL) and 98% triethylamine trihydrofluoride (0.25 mL). The reaction is followed by TLC and is found to be complete after 7.5 hours. The reaction mixture is then diluted with ethyl acetate and washed with 5% sodium bicarbonate, 5% sodium bisulfate and brine. The organic layer is dried over sodium sulfate and evaporated under vacuum. The crude product is chromatographed over silica gel (20 g), eluting with (40-60) acetone-hexane. Fractions of 7 mL are collected, analyzing them by TLC. Fractions 13-22 are combined and evaporated under vacuum to give Δ 12,13 -iso-baccatin III-13-(4S,5R)-N- Cbz-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (74a,b, 182 mg, 94% yield) as a white solid. TLC: silica gel; (40-60) ethyl acetate-hexane; Rf: 0.23 Proton NMR (CDC1 3 ; TMS): δ 1.16 (s, 12H); 1.28 (s, 3H); 1.66 (s, 3H); 1.90 (s, 3H); 1.98 (s, 3H); 2.26 (s, 3H); 2.43-2.55 (m, 2H); 3.73-3.81 (d, IH); 3.84 (s, 3H); 3.91 (s, 3H); 4.11-4.16 (d, IH); 4.21-4.27 (d, IH); 4.36-4.47 (m, IH); 4.50 (s IH); 4.82-4.92 (bd, IH); 4.92-4.96 (d, IH); 5.50-5.55 (d, IH); 5.61-5.68 (d, IH); 6.25-6.37 (m, 2H); 6.47-6.55 (m, 2H); 6.71 (s, IH); 7.23-7.57 (m, 8H); 7.57-7.64 (t, IH); 8.00-8.07 (d, 2H). Example 77 Preparation of 7-(O-methoxymethyl)-Δ 1 ' 13 -iso-baccatin III-13-(4S,5R)-N- Cbz-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxyHc acid ester (75a,b) Δ 12 13 -Iso-baccatin III-13-(4S,5R)-N-Cbz-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (74a,b, 215 mg, 0.208mM) is stirred at RT under nitogen in methylene chloride (1 mL) and the solution treated with chloromethyl methyl ether (97 μL, 1.25 mM) and diisopropyl ethyl amine (225 μL,1.25 mM). The reaction is followed by TLC. After 21 hours the reaction is found to be incomplete. Thus, additional chloromethyl methyl ether (48 μL, 0.62 mM) and diisopropyl ethyl amine (112 μL,0.62 mM) are added and the reaction continued for 24 hours, when it is found to be complete. The reaction is then diluted with methylene chloride and washed with 5% sodium bisulfate and 5% sodium bicarbonate, dried over sodium sulfate and evaporated under vacuum. The residue is chromatographed over silica gel (20 g), eluting with (40-60) acetone-hexane. Fractions of 5 mL are collected, analyzing them by TLC. Fractions 17-26 are combined and evaporated under vacuum to give 7-(O-methoxymethyl)-Δ 12,13 -iso-baccatin III-13-(4S,5R)-N-Cbz-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (75a,b, 224 mg, 100% yield) as a white solid. TLC: silica gel; (40-60) acetone-hexane; Rf: 0.44 Proton NMR (CDC1 3 ; TMS): δ 1.06 (s, 3H); 1.21 (s, 3H); 1.26 (s, 3H); 1.64 (ε, 3H); 2.11 (s, 3H); 2.16 (s, 3H); 2.44-2.69 (s+d, 2H); 2.70-2.88 ( , IH); 3.23 (s, 3H); 3.57-4.04 (m, 2H); 3.80 (s, 6H); 4.14-4.28 (d, IH); 4.28-4.38 (d, IH); 4.43-4.54 (d, IH); 4.55-4.84 (m, 4H); 4.84-4.96 (d, IH); 5.34-5.44 (d, IH); 5.44-5.53 (d, IH); 5.67 (s, IH); 6.30-6.58 (bd, IH); 6.74 (bs, 3H); 7.04-7.29 (m, 4H); 7.29-7.54 (m, 7H); 7.54-7.65 (t, IH); 7.93-8.06 (d, 2H). Example 78 Preparation of 7-(O-methoxymethyl)-13-(N-Cbz-β-phenyl isoserinyl)- Δ 12 ' 13 -iso-baccatin III (64) 7-(O-Methoxymethyl)-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)-N-Cbz-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (75a,b, 224 mg, 0.208mM) is stirred at RT under nitrogen in (80-20) acetic acid-water (9 mL). The reaction is followed by TLC and is found to be complete in 4.5 hours. The reaction is then freeze-dried. The residue is purified by chromatography over a silica gel column (25 g), eluting with a gradient of (40-60) to (60-40) ethyl acetate-hexane. Fractions of 7 mL are collected, analyzing them by TLC. The product is found in fractions 38-60 which are combined and evaporated under vacuum to give 7-(O- methoxymethyl)-13-(N-Cbz-β-phenyl isoserinyD-Δ^'^-iso-baccatin III (64,180 mg , 93% yield) as a white solid. TLC: silica gel; (40-60) ethyl acetate-hexane; Rf: 0.19 Proton NMR (CDC1 3 ; TMS): δ 1.08 (s, 3H); 1.21 (s, 3H); 1.59 (s, 3H); 1.68 (s, 3H); 1.82-2.03 (m, 2H); 2.12 (s, 3H); 2.16 (s, 3H); 2.74-2.94 (m, 2H); 3.23 (s, 3H); 3.66 (bs, IH); 3.77-3.86 (d, IH); 3.96-4.10 (dd IH); 4.23-4.35 (d, IH); 4.35-4.42(d, IH); 4.44-4.52 (d, IH); 4.60-4.94 (m, 5H); 5.40-5.56 (m, 2H); 5.75 (s, IH); 5.94-6.05 (d, IH); 6.94-7.04 (m, 2H); 7.10-7.23 (m, 3H); 7.25-7.42 (m, 9H); 7.42-7.53 (t, 2H); 7.53- 7.62 (t, IH); 8.08-8.20 (d, 2H). Mass Spec (FAB, m/z) (M+H) + measured at 928.3743; theory for C^^fi^ is 928.3755; 928, 896, 866, 105, 91, 43. Example 79 Preparation of 7-(O-ethoxymethyl)-13-(N-Cbz-β-phenyl isoserinyl)-Δ 12,13 - iso-baccatin III (69) Δ 12 ' 13 -Iso-baccatin III-13-(4S,5R)-N-Cbz-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (74a,b, 1.9g, 1.84 mM) is dissolved in CH 2 C1 2 (15mL) and the solution treated with chloromethylethyl ether (850 μL, 9.2 mM) and diisopropylethyl amine (2 mL, 11 mM). After stirring overnight TLC indicates reaction about 40% complete. Additional chloromethylethyl ether (850 mL, 9.2 mM) and diisopropylethyl amine (2 mL, 11 mM) are 2 times at 24 hour intervals after which the reaction is allowed to stir for two additional days. At this time TLC indicates no starting material left so the reaction is partitioned between EtOAc and IN HCI. The organic layer is reextracted with 5% NaHCO 3 and then brine. The organic layer is filtered through Na 2 SO 4 and concentrated in vacuo. To the residue is added (80-20) acetic acid water (100 mL). After 4 hr TLC shows that no starting material remains and the reaction mixture is lyophilized. The residue is chromatographed over silica gel (200 g) packed in (1-2) ethyl acetate hexane and the product added using CH 2 C1 2 . The column was eluted with 1.5L (2-3) ethyl acetate hexane (2-3,1.5 L; 1-1, 1L; and 2-1, 500 mL), collecting 50 mL fractions. 7-(O-ethoxymethyl)-13-(N-Cbz-β-phenyl isoserinyD-Δ^^-iso-baccatin III (69, 1.45 g, 82% yield) was found in fractions 34-51. MS: Theory 942.3912 Found 942.3901 Proton NMR (CDC1 3 ; TMS): δ 1.13 (m); 1.27 (m); 1.60 (s); 1.68 (s, 3H); 1.94 (m, 2H); 2.17 (s); 2.91 (m, 2H); 3.19 (d, IH); 3.35 (m, IH); 3.68 (m, IH); 3.83 (d, IH); 4.06 (m, IH); 4.32 (d, IH); 4.41 (d, IH); 4.59 (d, IH); 4.69 (d, IH); 4.75 (m, IH); 4.89 (m, 3H); 5.52 (m, 2H); 5.69 (d, IH); 5.76 (s, IH); 7.02 (m, 2H); 7.20 ( , 3H); 7.41-7.61 ( , 9H); 8.15 (d, IH). Example 80 Preparation of 13-(2'-TES-β-phenyl III (76) 13-(N-Cbz-2'-TES-β-phenyl isoserinyD-Δ^-iso-baccatin III (53, 100 mg, 0.1 mM) is stirred at RT under nitrogen in dry THF (1 mL) and methanol (1 mL) and the solution treated with ammonium formate (45 mg) and 10% Pd/C (25 mg). After 10 minutes the reaction is cooled in an ice bath and allowed to proceed for 60 min when TLC shows it to be complete. The reaction is then filtered through Celite, washing with ethyl acetate. The combined filtrate and wash are washed with 5% sodium bicarbonate, dried over sodium sulfate and evaporated under vacuum. The residue is reevaporated twice with toluene and once with ethyl acetate-hexane to give 13-(2'-TES-β-phenyl isoserinyl)-Δ 12 13 -iso-baccatin III (76, 88 mg, 100%) as a white solid. TLC: silica gel; (50-50) ethyl acetate-hexane; 1^:0.67. Proton NMR (CDCL 3 ; TMS): δ 0.40-0.58 (m, 6H); 0.76-0.90 (t, 9H); 0.94 (s, 3H); 1.17 (s, 3H); 1.45 (s, 3H); 1.51 (s, 3H); 2.13 (s, 3H); 2.70 (s, 3H); 3.53-3.63 (d, IH); 4.13-4.35 (m, 4H); 4.76-4.87 (dd, IH); 5.37 (s, IH); 5.40-5.48 (d, IH); 7.06-7.37 ( , 5H); 7.38-7.50 (t, 2H); 7.50-7.63 (t, IH); 7.90-8.02 (d, 2H). Example 81 Preparation of 13-(N-t-butylaminocarbonyl-2'-TES-β-phenyl isoserinyl)- Δ 12 - 13 -iso-baccatin III (77) 13-(2'-TES-β-phenyl isoserinyl)-Δ 12 ' 13 -iso-baccatin III (76, 88 mg, 0.1 mM) is stirred at 0°C under nitrogen in dry THF (1 mL). To this solution is added by syringe t-butyl isocyanate (0.02 mL). After 5 minutes, the reaction is warmed to RT, following it by TLC. After 1 hour the reaction is again cooled in ice bath and treated with t-butyl isocyanate (0.02 mL). The reaction is then warmed to RT and allowed to proceed overnight after which it is complete. The reaction is then evaporated under vaccum and the residue chromatographed over silica gel (10 g). The column is eluted with ethyl acetate-hexane (30-70, 200 mL) and (40-60, 100 mL). Fractions of 3 mL are collected, analyzing them by TLC. Fractions 22-72 are found to contained pure product and are combined and evaporated under vacuum to give 13-(N-t-butylaminocarbonyl-2'-TES-β-phenyl III (77, 87 mg, 92%) as a white solid. TLC: silica gel; (40-60) ethyl acetate-hexane; 1^:0.81. Proton NMR (CDCL 3 ; TMS): δ 0.17-0.44 (m, 6H); 0.64-0.80 (t, 9H); 1.03 (s, 3H); 1.06 (s. 9H); 1.28 (s, 3H); 1.60 (s, 3H); 1.61 (s, 3H); 1.77 (s, IH); 1.84-1.99 (t, IH); 2.00-2.15 (d, IH); 2.19 (s, 3H); 2.40-2.57 (m, IH); 2.65 (s, 3H); 2.76 (s, IH); 2.82-2.96 (d, IH); 3.52-3.59 (d, IH); 3.67-3.76 (d, IH); 4.26-4.43 (m, 3H); 4.46 (s, IH); 4.59 (s, IH); 4.89-4.99 (d, IH); 5.15-5.25 (d, IH); 5.47 (s, IH); 5.47-5.60 (m, 2H); 7.18-7.38 (m, 5H); 7.40-7.50 (t, 2H); 7.50-7.58 (t, IH); 8.04-8.14 (d, 2H). Example 82 Preparation of 7-(O-methylthiomethyl)-13-(N-t-butylaminocarbonyl-2'- TES-β-phenyl III (78) 13-(N-t-Butylammocarbonyl-2'-TES-β-phenyl isoserinyl)-Δ 12 ' 13 -iso-baccatin III (77, 87 mg, 0.091 mM) is stirred at 0°C under nitrogen in acetonitrile (1 mL). To this solution is added dimethyl sulfide (0.055 L) by syringe followed by four additions of benzoyl peroxide (25 mg each portion) at 5 min intervals. After 4 hours the reaction is found to be complete by TLC. The reaction is then partitioned between ethyl acetate-5% sodium bicarbonate. The organic layer is dried over sodium sulfate and evaporated under vacuum. The residue is chromatographed over silica gel (10 g), eluting with ethyl acetate-hexane (30-70). Fractions of 4 mL are collected, analyzing them by TLC. Fractions 9-21 contain pure product and are combined and evaporated under vacuum to give 7-(O-methylthiomethyl)-13-(N-t- butylaminocarbonyl-2'-TES-β-phenyl III (78, 73 mg, 78%) as a white solid. TLC: silica gel; (30-70) ethyl acetate-hexane; 1^:0.47. Proton NMR (CDCL 3 ; TMS): δ 0.12-0.37 (m, 6H); 0.61-0.74 (t, 9H); 1.04 (s, 9H); 1.05 (s. 3H); 1.21 (s, 3H); 1.63 (s, 3H); 1.64 (s, 3H); 1.78-1.92 (t, IH); 2.03 (s, 3H); 2.11 (s, 3H); 2.57 (s, 3H); 2.61 (s, 3H); 2.75-2.92 (m, 2H); 3.83-3.90 (d, IH); 4.04-4.14 (dd, IH); 4.21-4.29 (d, IH); 4.31-4.39 (d, IH); 4.42-4.60 ( , 4H); 4.85-4.93 (d, IH); 5.14-5.22 (d, IH); 5.44-5.52 (m, 2H); 5.84 (s, IH); 7.15-7.35 (m, 5H); 7.35- 7.45 (t, 2H); 7.45-7.55 (t, IH); 8.00-8.08 (d, 2H). Example 83 Preparation of 7-(O-methylthiomethyl)-13-(N-t-butylaminocarbonyl-β- phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (72) 7-(O-Methylthiomethyl)- 13-(N-t-butylaminocarbonyl-2'-TES-β-phenyl III (78, 73 mg, 0.071mM) is stirred at RT under nitrogen in (80-20) acetic acid-water (7 mL). TLC after 1 hour shows the reaction to be complete after which the reaction is freeze-dried. The residue is chromatographed over silica gel (10 g), eluting with (50-50) ethyl acetate-hexane. Fractions of 4 mL are collected, analyzing them by TLC. Fractions 12-30 are found to contain the pure product which upon evaporating leave 7-(O-methylthiomethyl)- 13-(N-t-butylaminocarbonyl-β-phenyl III (72, 50 mg, 77%) as a white solid. TLC: silica gel; (50-50) ethyl acetate-hexane; R^O.24. Proton NMR (CDCL 3 ; TMS): δ 1.03 (s, 3H); 1.06 (s, 9H); 1.17 (s, 3H); 1.56 (s, 3H); 1.60 (s, 3H); 1.73-1.87 (t, IH); 2.02 (s, 3H); 2.09 (s, 3H); 2.48 (s, 3H); 2.52 (s, IH); 2.69-2.86 (m, 2H); 3.76-3.84 (d, IH); 4.00-4.10 (dd, IH); 4.14-4.24 (d, IH); 4.28- 4.36 (d, IH); 4.40-4.65 (m, 4H); 4.80-4.90 (d, IH); 5.24-5.33 (d, IH); 5.33-5.42 (m, IH); 5.42-5.47 (d, IH); 5.80 (s, IH); 7.16-7.35 (m, 5H); 7.37-7.47 (t, 2H); 7.47-7.56 (t, IH); 7.99-8.06 (d, 2H). Example 84 PART A: Preparation of 2-(3-methylbutyl)dimethylsilyl-10-desacetylbaccatin III (80a). A solution of 1.04 g of 10-DAB in 3 mL of pyridine at room temperature is treated with 1.03 g of 2-(3-methylbutyl)dimethylsilylchloride (PDMSC1). The reaction mixture is stirred at room temperature for 7 hours at which point HPLC showed the reaction to be 99% complete. The mixture is poured into water and the product isolated with ethyl acetate. The ethyl acetate solution is dried over MgSO 4 and concentrated to afford 1.34 g of a foam after vacuum drying. PART B: Preparation of 2-(3-methylbutyl)dimethylsilyl-Baccatin III (81a). The crude material from Part A is dissolved in 8 mL of pyridine and cooled to 0°C. Acetyl chloride (0.735 mL) is then slowly added. The solution becomes a thick slurry and is stirred at 0°C for 6.5 hours and then placed in a -20°C freezer overnight. The next morning the reaction is quenched with methanol and the product isolated with ethyl acetate. The ethyl acetate solution is concentrated to an oil and the excess pyridine removed by azeotropic distillation with toluene. The crude product is chromatographed on silica gel with 40% ethyl acetate/cyclohexane to afford 1.14 g (84%) of 2-(3-methylbutyl)dimethylsilyl-Baccatin III. Example 85 Preparation of cyclohexyldimethylsilyl-10-DAB (80b). A solution of 182 mg of 10-DAB in 2 mL of pyridine is treated with 0.3 mL of cyclohexyldimethylsilyl chloride (CDMSC1) at room temperature. The solution is stirred at room temperature for 16 hours, quenched with ethanol, then poured into water and the product isolated with ethyl acetate. The crude product is chromatographed on sihca gel with 40% ethyl acetate/cyclohexane to afford 131 mg of pure silyl derivative. (Note: extended stir time results in considerable over silylation and results in reduced yield of cyclohexyldimethylsilyl- 10-DAB (80b). Example 86 As illustrated in Examples 84 and 85, silyl protective groups can be added by means well known to persons skilled in the art. See, for example, "Protective Groups in Organic Synthesis, 2ed.", Peter G. M. Wuts, pp 74-83, Wiley, New york, 1991 which is incorporated herein by reference. It has been reported that tributyldimethylsilyl (TBDMS) could not be introduced cleanly onto baccatin III, see footnote 13 in the Journal of the American Chemical Society (JACS), 110, 5917 (1988). Under reaction conditions tried to date, the introduction of TBDMS to baccatin III has not been successful. However, it is contemplated that TBDMS and triisopropylsilyl (TIPS) can be introduced onto baccatin III as well as iso-baccatin III under reaction conditions known in the art. Example 87 Preparation of 10-Deacetylbaccatin-7-O-triflate (82) A stirred solution of 10-deacetylbaccatin (10-DAB, 10.0 g, 0.0184 mole) in CH 2 C1 2 (50 mL) and pyridine (50 mL) is cooled to -30°C and triflic anhydride (3.85 mL, 6.42 g, 0.0229 mole) is added over a period of 20 minutes. The temperature of the solution is held below -15°C during the addition and is kept at -20 to -25°C for 30 min following the addition. A TLC (20% AcCN-CH 2 Cl 2 ) at this time shows a ratio of about 1:3 product to starting material. The reaction is then stirred at 0°C for two hours. A TLC at this time shows three spots of which the most polar and the least polar are smaller and the middle spot is major. At this point the reaction mixture may be acetylated as described in Example 88 or may be worked up as described below. The reaction mixture is first diluted with CH 2 C1 2 (2.5 L) and this solution is washed successively with 1M NaHSO 4 (3 x 1L), sat'd NaHCO 3 (2 x 1L), and 50% sat'd NaCl (1L). Each aqueous wash is back-extracted with CH 2 C1 2 (100 mL each) and the combined organic layers are dried (Na 2 >SO 4 ) and filtered. Since the reaction components do not move on sihca gel when CH 2 C1 2 is used as a solvent and because the 7-O-triflate is relatively insoluble, the entire extract (3 L) is applied directly to a flash sihca gel column (28 cm in 72 mm diameter column packed in CH 2 C1 2 ). The column is eluted with the following solvents: CH 2 C1 2 (1.5 L), 7.5% AcCN in CH 2 C1 2 (2 L), 10% AcCN in CH 2 C1 2 (2 L), 20% AcCN in CH 2 C1 2 (3 L), and with AcCN (2 L). Fractions (200 mL each) 20-22 contained 1.89 g (0.00233 mole, 12%) of bis-triflate. Fractions 31-37 contained 7.57 g (0.0112 mole, 61%) of 82 and fractions 42-47 contained 1.18 (12%) of recovered 10-DAB. Spectral data for 10-deacetylbaccatin-7-O-triflate (82): Η NMR (CDC1 3 , TMS) δ 8.09 (d), 7.64, 7.49 (t), 5.65 (d), 5.46 (dd), 5.43 (s), 4.94 (m), 4.37 (d), 4.18 (d), 4.00 (s), 2.31 (s), 2.10 (s), 1.91 (s), 1.10 (s). Example 88 Preparation of Baccatin-III-7-O-triflate. (83=20) To the reaction mixture at 0°C from Example 87, acetic anhydride (43.5 mL, 47.1 g, 0.461 mole) is added. Following the addition, the reaction solution is warmed in an oil bath at 50°C for 15 minutes after which TLC indicates about 90% conversion of the major triflation product to a new material. The reaction is cooled in an ice bath and quenched by the addition of water (50 mL) from an addition funnel over a period of 30 min while maintaining the temperature below 10°C. EtOAc (50 mL) is stirred into the mixture with no additional release of heat. This mixture is added to EtOAc (500 mL) and the resulting mixture washed with 5% NaHSO 4 (2 x 500 mL), with sat'd NaHCO 3 (3 x 500mL), and with sat'd NaCl (500 mL). Each aqueous layer is back-extracted with the same 50 mL of EtOAc. The combined organic extracts were dried (Na 2 SO 4 ), filtered, and concentrated. The crude product (14.5 g) is dissolved in CH 2 C1 2 (150 mL plus two 50 mL rinses) and applied to a flash sihca gel column (7 inches dry packed in an 80 mm diameter column). The column is eluted with CH 2 C1 2 (500 mL), 5% AcCN in CH 2 C1 2 (1L), 7.5% AcCN in CH 2 C1 2 (2L), 10% AcCN in CH 2 C1 2 (2L), and AcCN (2L). Baccatin III-7-O- triflate (83) is eluted in fractions 11-19 (7.36 g, 0.0102 mole, 55% from 10-DAB); Η NMR spectrum in CDC1 3 is identical to the spectrum described for 20 derived in Example 15 from baccatin III. Example 89 Preparation of 13-ketobaccatin III 7-triflate (84) Baccatin III 7-triflate (83, 100 mg, 0.17 mM) is dissolved in methylene chloride (2 mL) and the solution treated with manganese dioxide (300 mg, 3.45 mM) and the solution stirred for 18 hr at which point TLC indicates the reaction is not yet completed. Additional manganese dioxide (100 mg, 1.15 mM) is add and the reaction stirred an additional 3 hr. The reaction is then filtered through celite and concentrated under vacuum leaving 13-ketobaccatin III 7-triflate (84, 90 mg). Proton NMR (CDC1 3 ; TMS): δ 1.21 (s, 3H); 1.28 (s, 3H); 1.86(s, 3H); 2.22 (s, 3H); 2.23 (s, 3H); 2.26 (s, 3H); 2.82 (d, J=20 Hz, IH); 2.80-2.89 (m, IH); 2.95 (d, J=20 Hz, IH); 4.02 (d, J=8.6 Hz IH); 4.11 (d, J=8.4, IH); 4.38 (d, J=8.4 Hz, IH); 4.91 (d, J=7.8 Hz, IH); 5.50 (dd, IH); 5.74 (d, J=6.6 Hz, IH); 6.75 (s, IH); 7.51 (t, 2H); 7.65 (t, IH); 8.06 (d, 2H). Example 91 Preparation of Δ 1213 -iso-baccatin III 7-triflate (85) As described for the preparation of 7-TES-Δ 1213 -iso-baccatin III (3) in Example 2 but starting with 13-ketobaccatin III 7-triflate (84) is prepared Δ 12,13 -iso-baccatin III 7- triflate (85). Example 92 Preparation of 7-(O-trifluoromethanesulfonyl)-Δ 12,13 -isobaccatin III, 13- (4S,5R)-N-Carbobenzyloxy-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazoUdinecarboxyhc Acid Ester (86 a,b) As described for the preparation of 7-TES-Δ 12,13 -isobaccatin III, 13-(4S,5R)-N- Cbz-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxylic acid ester (51a,b) in Example 47 but starting with Δ^ so-baccatin III 7-triflate (85) is prepared 7-(O- trifluoromethanesulfonyD-Δ^'^-isobaccatin lll, 13-(4S,5R)-N-Cbz-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic Acid Ester (86 a,b). Example 93 Preparation of 7-(O-trifluoromethanesulfonyl)-13-(N-Cbz-β-phenyl As described for the preparation of 13-(N-Cbz-β-phenyl baccatin III (52) in Example 48 but starting with 7-(O-trifluoromethanesulfonyl)- Δ 12,13 -isobaccatin III, 13-(4S,5R)-N-Cbz-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic Acid Ester (86 a,b) is prepared 7-(O-trifluoromethanesulfonyl)- 13-(N-Cbz-β-phenyl isoserinyl)-Δ 12 ' 13 -iso-baccatin III (87). Example 94 Preparation of 7-(O-trifluoromethanesulfonyl)-13-(N-Cbz-2'-TES-β- phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (54) As described for the preparation of 13-(N-Cbz-2'-TES-β-phenyl isoserinyl)- Δ 1 ,13 -iso-baccatin III (53) in Example 49 is prepared 7-(O-trifluoromethanesulfonyl)- 13-(N-Cbz-2'-TES-β-phenyl isoserinyl)-Δ 1213 -iso-baccatin III (54). This material gives the same physical data on TLC and in the NMR as compound 54 prepared in example 50. Example 95 Preparation of 13-(N-Cbz-β-phenyl isoserinyl)-7-deoxy-7β,8β-methano- Δ 12 ' 13 -iso-baccatin III (88) As described for the preparation of 13-(N-Cbz-2'-TES-β-phenyl isoserinyl)-7- deoxy-7β,8β-methano-Δ 12,13 -iso-baccatin III (55) in Example 51 but starting with 7-(O- trifluoromethanesulfonyl)-13-(N-Cbz-β-phenyl isoserinyD-Δ^'^-iso-baccatin III (87) in place of 7-(O-trifluoromethanesulfonyl)-13-(N-Cbz-2'-TES-β-phenyl isoserinyl)-Δ 12,13 - iso-baccatin III (54) is prepared 13-(N-Cbz-β-phenyl isoserinyl)-7-deoxy-7β,8β- methano-Δ^'^-iso-baccatin III (88). Example 96 Preparation of 13-(β-phenyl isoserinyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso- baccatin III (89) As described for the preparation of 13-(2'-TES-β-phenyl isoserinyl)-7-deoxy- 7β,8β-methano-Δ 12,13 -iso-baccatin III (57) in Example 52 but starting with starting with 13-(N-Cbz-β-phenyl isoserinyl)-7-deoxy-7β,8β-methano-Δ 1 ,13 -iso-baccatin III (88) in place of 13-(N-Cbz-2'-TES-β-phenyl isoserinyl)-7-deoxy-7β,8β-methano-Δ 1213 -iso- baccatin III (55) is prepared 13-(β-phenyl isoserinyl)-7-deoxy-7β,8β-methano-Δ 1 ,13 -iso- baccatin III (89). Example 97 Preparation of 13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-7β,8β-methano- Δ 12 13 -iso-baccatin III (17) As described for the preparation of 13-(N-Boc-2'-TES-β-phenyl isoserinyl)-7- deoxy-7β,8β-methano-Δ 12,13 -iso-baccatin III (58) in Example 53 but starting with 13- (β-phenyl isoserinyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-baccatin III (89) in place of 13- (2'-TES-β-phenyl isoserinyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-baccatin III (57) is prepared 13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-7β,8β-methano-Δ 1 ' 13 -iso-baccatin III (17). Example 98 Preparation of 13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-7- deoxy-7β,8β-methano-Δ 12,13 -iso-baccatin III (36) As described for the preparation of 13-(N-(t-butylaminocarbonyl)-2'-TES-β- phenyl isoserinyl)-7-deoxy-7β,8β-methano-Δ 1 ,13 -iso-baccatin III (59) in Example 55 but starting with 13-(β-phenyl isoserinyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-baccatin III (89) in place of 13-(2'-TES-β-phenyl isoserinyl)-7-deoxy-7β,8β-methano-Δ 12ll3 -iso- baccatin III (57) is prepared 13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-7- deoxy-7β,8β-methano-Δ 12,13 -iso-baccatin III (36). Example 99 Preparation of 13-(N-Cbz-β-phenyl isoserinyl)-7-deoxy-Δ 6,7 ,Δ 12,13 -iso- baccatin III (90) As described for the preparation of 13-(N-Cbz-2'-TES-β-phenyl isoserinyl)-7- III (56) in Example 57 but starting with 7-(O- trifluoromethanesulfonyl)-13-(N-Cbz-β-phenyl isoserinyl)-Δ 1 ,13 -iso-baccatin III (87) in place of 7-(O-trifluoromethanesulfonyl)-13-(N-Cbz-2'-TES-β-phenyl isoserinyl)-Δ 12>13 - iso-baccatin III (54) is prepared 13-(N-Cbz-β-phenyl isoserinyl)-7-deoxy-Δ 6,7 ,Δ 12 ' 13 -iso- baccatin III (90). Example 100 Preparation of 13-(β-phenyl isoserinyl)-7-deoxy-Δ 6,7 ,Δ "'"-iso-baccatin III (91) As described for the preparation of 13-(2'-TES-β-phenyl isoserinyl)-7-deoxy- Δ 6,7 ,Δ 12,13 -iso-baccatin III (60) in Example 58 but starting with starting with 13-(N- Cbz-β-phenyl isoserinyl)-7-deo3^-Δ 6,7 ,Δ 12 ' 13 -iso-baccatin III (90) in place of 13-(N-Cbz- 2'-TES-β-phenyl isoserinyl)-7-deoxy-Δ 6 ' 7 ,Δ 12 ' 13 -iso-baccatin III (56) is prepared 13-(β- phenyl isoserinyl)-7-deoxy-Δ 6,7 ,Δ 12,13 -iso-baccatin III (91). Example 101 Preparation of 13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-Δ 6,7 ,Δ 12,13 -iso- baccatin III (18) As described for the preparation of 13-(N-Boc-2'-TES-β-phenyl isoserinyl)-7- deoxy-Δ 6 ' 7 ,Δ 1213 -iso-baccatin III (61) in Example 59 but starting with 13-(β-phenyl isoserinyl)-7-deoxy-Δ 6 ' 7 ,Δ 12 - 13 -iso-baccatin III (91) in place of 13-(2'-TES-β-phenyl isoserinyl)-7-deoxy-Δ 6,7 ,Δ 12,13 -iso-baccatin III (56) is prepared 13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-Δ 6,7 ,Δ 12,13 -iso-baccatin III (18). Example 102 Preparation of 13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-7- deoxy-Δ 6 - 7 ,Δ 1 ' 13 -iso-baccatin III (38) As described for the preparation of 13-(N-(t-butylaminocarbonyl)-2'-TES-β- phenyl isoserinyl)-7-deoxy-Δ 6,7 ,Δ 12,13 -iso-baccatin III (62) in Example 61 but starting with 13-(β-phenyl isoserinyl)-7-deoxy-Δ 6 - 7 ,Δ 12 ' 13 -iso-baccatin III (91) in place of 13-(2'- TES-β-phenyl isoserinyl)-7-deoxy-Δ 6,7 ,Δ 12,13 -iso-baccatin III (60) is prepared 13-(N-(t- butylaminocarbonyl)-β-phenyl isoserinyl)-7-deoxy-Δ 6,7 ,Δ 12,13 -iso-baccatin III (38). Example 103 Preparation of 10-deacetyl-13-keto-baccatin III (93) Jones reagent is prepared by dissolving chromium trioxide (10.3 g, 0.103 mM) in a mixture of concentrated sulfuric acid (8.7 mL) and water (30 mL). A solution of 10-deacetylbaccatin III (92, 23 mg, 0.043 mM) in acetone (1.6 mL) is cooled to -50 °C. To this is added the Jones reagent (11 μL, 0.028 mM). The reaction is stirred 20 minutes, then quenched with 2-propanol. The mixture is partitioned between ethyl acetate and 5% sodium bicarbonate solution. The organic layer is dried over anhydrous sodium sulfate and evaporated to give 25 mg of crude product. The product is purified by column chromatography on sihca gel in acetone-hexane mixtures, giving 10-deacetyl-13-keto-baccatin III (93, 5.3 mg - 23% yield). Starting material (12 mg, 52%) is also recovered. TLC (Sihca Gel GF): R f of product in (50-50) acetone-hexane = 0.44; R f of starting material = 0.31. ) Proton NMR (CDC1 3 ; TMS): δ 1.19 (s, 3H); 1.24 (s, 3H); 1.47 (d, IH); 1.75 (s, 3H); 1.85 (m, IH); 2.10 (s, 3H); 2.20 (s, 3H); 2.60 (m, IH); 2.68 (d, IH); 2.97 (d, IH); 4.02 (d, IH); 4.15 (d, IH); 4.26 (d, IH); 4.30 (m, IH); 4.35 (d, IH); 4.95 (dd, IH); 5.42 (d, IH); 5.70 (d, IH); 7.51 (m, 2H); 7.64 (m, IH); 8.07 (d, 2H). Example 104 Preparation of lO-deacetyl-Δ^-^-iso-baccatin III (94) As described for the preparation of 7-TES-Δ 12,13 -iso-baccatin III (3) in example 2 but starting with 10-deacetyl-13-keto-baccatin III (93) in place of 13-keto- 7-TES-baccatin III (2) is prepared lO-deacetyl-Δ^-iso-baccatin III (94). Example 105 Preparation of 10-deacetyl-7-(O-trifluoromethanesulfonyl)-Δ 12,13 -iso- baccatin III (95) As described for the preparation of 10-deacetyl-7-(O- trifluoromethanesulfonyl-baccatin III (82) in example 87 but starting with 10- deacetyl-Δ 12,13 -iso-baccatin III (94) in place of 10-deacetyl-baccatin III (79) is prepared 10-deacetyl-7-(O-trifluoromethanesulfonyl)-Δ 12 ' 13 -iso-baccatin III (95). Example 106 Preparation of 7-(O-trifluoromethanesulfonyl)-Δ 12,13 -iso-baccatin III (85) As described for the preparation of 7-(O-trifluoromethanesulfonyl)-baccatin III (83) in example 88 but starting with lO-deacetyl-(O-trifluoromethanesulfonyl)- Δ 12,13 -iso-baccatin III (95) in place of 10-deacetyl-7-(O-trifluoromethanesulfonyl)- baccatin III (82) is prepared 7-(O-trifluoromethanesulfonyl)-Δ 12,13 -iso-baccatin III (85) Example 107 Preparation of 10-deacetyl-7-(O-methoxymethyl)-baccatin III (96) As described for the preparation of 7-(O-methoxymethyl)-Δ 12 ' 13 -iso-baccatin III- 13-(4S,5R)-N-Cbz-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxylic acid ester (75a,b,) in example 77 but starting with 10-deacetyl-baccatin III (92) in place of Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)-N-Cbz-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (74a,b) is prepared 10-deacetyl-7-(O-methoxymethyl)- baccatin III (96). Example 108 Preparation of 7-(O-methoxymethyl)-baccatin III (97) As described for the preparation of 7-(O-trifluoromethanesulfonyl)-baccatin III (83) in example 88 but starting with 10-deacetyl-7-(O-methoxymethyl)-baccatin III (96) in place of lO-deacetyl-7-trifluoromethansulfonyl-baccatin III (82) is prepared 7-(O-methoxymethyl)-baccatin III (97). Example 109 Preparation of 13-keto-7-(O-methoxymethyl)-baccatin III (98) As described for the preparation of 13-keto-7-TES-baccatin III (2) in example 1 but starting with 7-(O-methoxymethyl)-baccatin III (97) in place of 7-TES-baccatin III (1) is prepared 13-keto-7-(O-methoxymethyl)-baccatin III (98). Example 110 Preparation of 7-(O-methoxymethyl)-Δ 1 ,13 -iso-baccatin III (99) As described for the preparation of 7-TES-Δ 12 ' 13 -iso-baccatin III (3) in example 2 but starting with 13-keto-7-(O-methoxymethyl)-baccatin III (98) in place of 13- keto-7-TES-baccatin III (2) is prepared 7-(O-methoxymethyl)-Δ 12 ' 13 -iso-baccatin III (99). Example 111 Preparation of 7-(O-methoxymethyl)-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)- N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxyhc acid ester (75a,b) As described for the preparation of 7-TES-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)-N- Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazo dinecarboxyhc acid ester (5a,b) in -I l l- example 3 but starting with 7-(O-methoxymethyl)-Δ 12 ' 13 -iso-baccatin III (99) in place of 7-TES-Δ 12,13 -iso-baccatin III (3) is prepared 7-(O-methoxymethyl)-Δ 12,13 -iso-baccatin III-13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxyhc acid ester (75a,b). Example 112 Preparation of 10-deacetyl-7-(O-methylthiomethyl)-baccatin III (100) As described for the preparation of 7-(O-methylthiomethyl)-Δ 12,13 -iso-baccatin III-13-(4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester ( 1a,b) in example 73 but starting with 10-deacetyl- baccatin III (92) in place of Δ 1213 -iso-baccatin III-13-(4S,5R)-N-(t- butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxyhc acid ester (33a,b) is prepared 10-deacetyl-7-(O-methylthiomethyl)-baccatin III (100). Example 113 Preparation of 7-(O-methylthiomethyl)-baccatin III (101) As described for the preparation of 7-(O-trifluoromethanesulfonyl)-baccatin III (83) in example 88 but starting with 10-deacetyl-7-(O-methylthiomethyl)-baccatin III (100) in place of 10-deacetyl-7-(O-trifluoromethansulfonyl)-baccatin III (82) is prepared 7-(O-methylthiomethyl)-baccatin III (101). Example 114 Preparation of 13-keto-7-(O-methylthiomethyl)-baccatin III (102) As described for the preparation of 13-keto-7-TES-baccatin III (2) in example 1 but starting with 7-(O-methylthiomethyl)-baccatin III (101) in place of 7-TES- baccatin III (1) is prepared 13-keto-7-(O-methylthiomethyl)-baccatin III (102). Example 115 Preparation of 7-(O-methylthiomethyl)-Δ 12,13 -iso-baccatin III (103) As described for the preparation of 7-TES-Δ 12,13 -iso-baccatin III (3) in example 2 but starting with 13-keto-7-(O-methylthiomethyl)-baccatin III (102) in place of 13- keto-7-TES-baccatin III (2) is prepared 7-(O-methylthiomethyl)-Δ 1213 -iso-baccatin III (103). Example 116 Preparation of 7-(O-methylthiomethyl)-Δ 12 ' 13 -iso-baccatin 111-13- (4S,5R)-N-Cbz-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxyhc acid ester (104a,b) As described for the preparation of 7-TES-Δ 12 13 -iso-baccatin III-13-(4S,5R)-N- Cbz-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxylic acid ester (51a,b) in example 47 but starting with 7-(O-methylthiomethyl)-Δ 12,13 -iso-baccatin III (103) in place of 7-TES-Δ 12,13 -iso-baccatin III (3) is prepared 7-(O-methylthiomethyl)-Δ 12 ' 13 -iso- baccatin III-13-(4S,5R)-N-Cbz-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazohdinecarboxyhc acid ester (104a,b). Example 117 Preparation of 7-(O-methylthiomethyl)-13-(N-Cbz-β-phenyl isoserinyl)- Δ 12 - 13 -iso-baccatin III (105) As described for the preparation of 7-(O-methylthiomethyl)-13-(N-t- butylaminocarbonyl-β-phenyl isoserinyD-Δ^ so-baccatin III (72) in example 74 but starting with 7-(O-methylthiomethyl)-Δ 12,13 -iso-baccatin III-13-(4S,5R)-N-Cbz-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (104a,b) in place of 7- (O-methylthiomethyl)-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)-N-(t-butylaminocarbonyl)-2- (2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxyhc acid ester (71a,b) is prepared 7-(O-methylthiomethyl)-13-(N-Cbz-β-phenyl III (105) Example 118 Preparation of 7-(O-methylthiomethyl)-13-(β-phenyl isoserinyl)-Δ 12,13 - iso-baccatin III (106) As described for the preparation of 7-(O-methoxymethyl)-13-(β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (65) in example 65 but starting with 7-(O- methylthiomethyl)-13-(N-Cbz-β-phenyl III (105) in place of 7-(O-methoxymethyl)-13-(N-Cbz-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (64) is prepared 7-(O-methylthiomethyl)-13-(β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (106) Example 119 Preparation of 7-(O-methylthiomethyl)-13-(N-Boc-β-phenyl isoserinyl)- Δ 12,13 -iso-baccatin III (107) As described for the preparation of 7-(O-methoxymethyl)-13-(N-Boc-β-phenyl III (66) in example 66 but starting with 7-(O- methylthiomethyl)-13-(β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (106) in place of 7- (O-methoxymethyl)-13-(β-phenyl isoserinyD-Δ^'^-iso-baccatin III (65) is prepared 7- (O-methylthiomethyl)-13-(N-Boc-β-phenyl III (107) Example 120 Preparation of 7-(O-methylthiomethyl)-13-(N-(t-butylaminocarbonyl)-β- phenyl III (72) As described for the preparation of 7-(O-methoxymethyl)-13-(N-(t- butylaminocarbonyl)-β-phenyl III (67) in example 67 but starting with 7-(O-methylthiomethyl)-13-(β-phenyl III (106) in place of 7-(O-methoxymethyl)-13-(β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (65) is prepared 7-(O-methylthiomethyl)-13-(N-(t-butylaminocarbonyl)-Boc-β- phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (72.) Example 121 Preparation of 10-deacetyl-7-(O-methyl)-baccatin III (108) As described for the preparation of 7-(O-methyl)-13-(N-t-butylaminocarbonyl- β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (73) in example 75 but starting with 10- deacetyl-7-(O-methylthiomethyl)-baccatin III (100) in place of 7- (O- methylthiomethyl)-13-(N-t-butylaminocarbonyl-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (72) is prepared 10-deacetyl-7-(O-methyl)-baccatin III (108). Example 122 Preparation of 7-(O-methyl)-baccatin III (109) As described for the preparation of 7-(O-trifluoromethanesulfonyl)-baccatin III (83) in example 88 but starting with 10-deacetyl-(O-methyl)-baccatin III (108) in place of 10-deacetyl-7-(O-trifluoromethanesulfonyl)-baccatin III (82) is prepared 7-(O- methyD-baccatin III (109) Example 123 Preparation of 7-(O-methyl)-baccatin III (109) As described for the preparation of 7-(O-methyl)-13-(N-t-butylaminocarbonyl- β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (73) in example 75 but starting with 7-(O- methylthiomethyD-baccatin III (101) in place of 7-(O-methylthiomethyl)-13-(N-t- butylaminocarbonyl-β-phenyl isoserinyD-Δ^'^-iso-baccatin III (72) is prepared 7-(O- methyD-baccatin III (109). Example 124 Preparation of 13-keto-7-(O-methyl)-baccatin III (110) As described for the preparation of 13-keto-7-TES-baccatin III (2) in example 1 but starting with 7-(O-methyl)-baccatin III (109) in place of 7-TES-baccatin III (1) is prepared 13-keto-7-(O-methyl)-baccatin III (110). Example 125 Preparation of 7-(O-methyl)-Δ 12 ' 13 -iso-baccatin III (111) As described for the preparation of 7-TES-Δ 12,13 -iso-baccatin III (3) in example 2 but starting with 13-keto-7-(O-methyl)-baccatin III (110) in place of 13-keto-7-TES- baccatin III (2) is prepared 7-(O-methyl)-Δ 12 ' 13 -iso-baccatin III (111). Example 126 Preparation of 7-(O-methyl)-Δ 1213 -iso-baccatin III-13-(4S,5R)-N-Cbz-2- (2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxylic acid ester (112a,b) As described for the preparation of 7-TES-Δ 1213 -iso-baccatin IIM3-(4S,5R)-N- Cbz-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxylic acid ester (51a,b) in example 47 but starting with 7-(O-methyl)-Δ 12,13 -iso-baccatin III (111) in place of 7- TES-Δ 12,13 -iso-baccatin III (3) is prepared 7-(O-methyl)-Δ 12>13 -iso-baccatin 111-13- (4S ,5R)-N-Cbz-2-(2 ,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester (112a,b). Example 127 Preparation of 7-(O-methyl)-13-(N-Cbz-β-phenyl isoserinyl)-Δ 12,13 -iso- baccatin III (113) As described for the preparation of 7-(O-methylthiomethyl)-13-(N-t- butylaminocarbonyl-β-phenyl III (72) in example 74 but starting with 7-(O-methyl)-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)-N-Cbz-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxylic acid ester (112a,b) in place of 7-(O-methylthiomethyl)-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)-N-(t-butylaminocarbonyl)-2- (2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxyhc acid ester (71a,b) is prepared 7-(O-methyl)-13-(N-Cbz-β-phenyl III (113). Example 128 Preparation of 7-(O-methyl)-13-(β-phenyl isoserinyD-Δ^'^-iso-baccatin III (114) As described for the preparation of 7-(O-methoxymethyl)-13-(β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (65) in example 65 but starting with 7-(O-methyl)- 13-(N-Cbz-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (113) in place of 7-(O- methoxymethyl)-13-(N-Cbz-β-phenyl III (64) is prepared 7-(O-methyl)-13-(β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (114). Example 129 Preparation of 7-(O-methyl)-13-(N-Boc-β-phenyl isoserinyl)-Δ 12 ' 13 -iso- baccatin III (115) As described for the preparation of 7-(O-methoxymethyl)-13-(N-Boc-β-phenyl III (66) in example 66 but starting with 7-(O-methyl)- 13-(β-phenyl III (114) in place of 7-(O-methoxymethyl)- 13-(β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (65) is prepared 7-(O-methyl)-13-(N-Boc-β-phenyl III (115). Example 130 Preparation of 7-(O-methyl)-13-(N-(t-butylaminocarbonyl)-β-phenyl As described for the preparation of 7-(O-methoxymethyl)-13-(N-(t- butylaminocarbonyl)-β phenyl III (67) in example 67 but starting with 7-(O-methyl)-13-(β-phenyl isoserinyl)-Δ 12 ' 13 -iso-baccatin III (114) in place of 7-(O-methoxymethyl)-13-(β-phenyl III (65) is prepared 7-(O-methyl)- 13-(N-(t-butylaminocarbonyl)-Boc-β-phenyl isoserinyl)-Δ 12,13 - iso-baccatin III (73.) Example 131 Preparation of 10-deacetyl-7-(O-methoxymethyl)-Δ 1213 -iso-baccatin III (116) As described for the preparation of 7-(O-methoxymethyl)-Δ 12,13 -iso-baccatin III-13-(4S,5R)-N-Cbz-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxylic acid ester (75a,b,) in example 77 but starting with 10-deacetyl-baccatin III (94) in place of Δ 12 - 13 -iso-baccatin III-13-(4S,5R)-N-Cbz-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (74a,b) is prepared 10-deacetyl-7-(O-methoxymethyl)- Δ 12 13 -iso-baccatin III (116). Example 132 Preparation of 7-(O-methoxymethyl)-Δ 1 ,13 -iso-baccatin III (99) As described for the preparation of 7-(O-trifluoromethanesulfonyl)-baccatin III (83) in example 88 but starting with 10-deacetyl-7-(O-methoxymethyl)-Δ 12,13 -iso- baccatin III (116) in place of lO-deacetyl-7-trifluoromethansulfonyl-baccatin III (82) is prepared 7-(O-methoxymethyl)-Δ 1213 -iso-baccatin III (99). Example 133 Preparation of 10-deacetyl-7-(O-methylthiomethyl)-Δ 1213 -iso-baccatin III (117) As described for the preparation of 7-(O-methylthiomethyl)-Δ 12 ' :l3 -iso-baccatin III-13-(4S,5R)-N-(t-buiylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazohdinecarboxyhc acid ester (71a,b) in example 73 but starting with 10-deacetyl- Δ 12|13 -baccatin III (94) in place of Δ^ so-baccatin III-13-(4S,5R)-N-(t- butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxyhc acid ester (33a,b) is prepared 10-deacetyl-7-(O-methylthiomethyl)-Δ 12,13 -iso-baccatin III (117). Example 134 Preparation of 7-(O-methylthiomethyl)-Δ 1213 -iso-baccatin III (103) As described for the preparation of 7-(O-trifluoromethanesulfonyl)-baccatin III (83) in example 88 but starting with 10-deacetyl-7-(O-methylthiomethyl)-Δ 12,13 -iso- baccatiu III (117) in place of 10-deacetyl-7-trifluoromethansulfonyl-baccatin III (82) is prepared 7-(O-methylthiomethyl)-Δ 12,13 -iso-baccatin III (103). Examole 135 Preparation of 7-(O-methyl)-Δ 12 ' 13 -iso-baccatin III (111) As described for the preparation of 7-(O-methyl)-13-(N-t-butylaminocarbonyl- β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (73) in example 75 but starting with 7-(O- methylthiomethyl)-Δ 12,13 -iso-baccatin III (103) in place of 7- (O-methylthiomethyl)-13- (N-t-butylaminocarbonyl-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (72) is prepared 7- (O-methyD-Δ^-iso-baccatin III (111). Example 136 Part A Charge oxazoline acid (2.60 g, 9.73 mmol) into a round bottom flask and slurry in toluene (20 ml). At room temperature add 1,3-dicyclohexylcarbodiimide (960 mg, 4.65 mmol) and stir for 20 minutes. Add 7-2-(3-methylbutyl) dimethyl- silyloxy baccatin III (1.0 g, 1.40 mmol) in toluene (15 ml) followed by catalytic 4- pyrrolidinopyridine. Stir the mixture at room temperature. After 1 hour, reaction is complete by TLC. Quench with 20% NaHCO 3 (50 ml) and stir at room temperature for 2 hours. Filter on a coarse frit to remove the DCU and separate the phases. Back extract the aqueous with methyl t-butylether (35 ml). Wash the combined organics with 50% NaHCO 3 (50 ml), brine (50 ml) and dry over Na j SO 4 . Concentrate to solids. Purify by column chromatography with 3:1 cyclohexanes/ Ethyl acetate to afford coupled ester 118 as a white solid. Part B Charge the coupled ester (1.16 g, 1.2 mmol) into a round bottom flask and dissolve in MeOH (11 ml). Add IN HCI (1.25 ml, 1.25 mmol) at room temperature. Heat the resultant mixture to reflux. After 2 hours at reflux, the reaction is done by TLC. Cool to room temperature. Add aq NaHCO 3 (535 mg 10 ml H 2 O). Stir at room temperature for 2 hours. Remove the MeOH under vacuum, then extract mixture with EtOAc (2 x 25 ml). Dry the organics over Na 2 SO 4 and concentrate to sohds. By TLC the solids are a mixture of the O-benzoyl salt and taxol. Dissolve the solids in a small amount of EtOAc and add 2 drops of triethylamine. Leave overnight. After 16 hours, the migration is complete and the crude sohds are purified by column chromatography using 1.5:1 Ethyl acetate/cyclohexanes to afford taxol. Example 137 Following the general procedure of Example 136 but substituting 7-2-(3- methylbutyDdimethylsilyloxy Δ^-^-iso-baccatin III for 7-2-(3-methylbutyl)dimethyl- silyloxy baccatin III, Δ^'^-iso-taxol is prepared. Example 138 Formation of 7-[0-2-(3-methylbutyl)dimethylsilyl]-taxol (119) A solution of 1.02 g of the product of Example 136, Part A (Compound 118) in 12 mL of AcOH and 1.5 mL water is heated at 80C for one hour. The solution is cooled and the product isolated by chromatography after isolation with ethyl acetate to afford 680 mg of Compound 119. Preparation A 2'-{[(2,2,2-trichloroethyl)oxy]carbonyl}-Δ 12,13 -iso-taxol is prepared as discribed for the preparation of 2'-{[(2,2,2-trichloroethyl)oxy]carbonyl}taxol [Magri, N. F.; Kingston, D. G. I. J. Org. Chem., 1986, 51, 797] Preparation B 2'-[{(2,2,2-Trichloroethyl)oxy}carbonyl]-Δ 12 ' 13 -iso-taxol, 7- Methanesulfonate Methanesulfonyl chloride (1.2 equivalents) is added dropwise to a solution of 2'-[{(2,2,2-Trichloroethyl)oxy}carbonyl]-Δ 12,13 -iso-taxol (1 equivalent) and pyridine (5 equivalents) in CH 2 C1 2 which is stirred at ice-bath temperature. The reaction mixture is allowed to warm and stirring is continued until tic evidence indicates that reaction is complete. The reaction mixture is quenched with ice water and is extracted with CH 2 C1 2 and these extracts are washed successively with dilute aqueous acid, dilute aqueous NaHCO 3 , and water and then are dried, filtered, and concentrated to give the crude reaction product. Chromatography of the crude product over sihca gel gives pure title compound. Preparation C 2'-[{(2,2,2-Trichloroethyl)oxy}carbonyl]-7-deoxy-7α-chloro-Δ 12 ' 13 -iso- taxol A solution of 2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-Δ 12,13 -iso-taxol, 7-methanesulfonate (1 equiv.) in N,N-dimethylformamide (DMF) is stirred with potassium chloride (10 equiv.). A phase transfer catalyst is added and the reaction mixture is warmed to increase the rate of reaction. The course of the reaction is followed by tic. The reaction mixture is worked up by the addition of water and extraction with CH 2 C1 2 . The organic extracts are dried, filtered, and concentrated and the crude reaction product residue is chromatographed over sihca gel, yielding the pure title compound. Preparation D Preparation of 7-deoxy-7α-chloro-Δ 12 ' 13 -iso-taxol A solution of 2'-[{(2,2,2-Trichloroethyl)oxy}carbonyl]-7-deoxy-7α-chloro-Δ 12,13 -iso- taxol in 9:1 methanol/acetic acid is stirred with activated zinc metal at room temperature . After 90 min, the reaction is worked up by removal of the zinc by filtration and concentration of the filtrate under reduced pressure. The residue is dissolved in CH 2 C1 2 and this solution washed with 0.1N aq. HCI, with 5% aq. NaHCO 3 , and with water. The aqueous layer is back extracted with CH 2 C1 2 and the combined organic extracts are dried (Na^O , filtered, and concentrated to give a residue. The residue is pruified by chromatography over silica gel and is obtained as a sohd. Preparation E 7-Deoxy-7β-chloro-Δ 12 13 -iso-taxol Following the procedures of Examples A,B,C,D and E, but starting with 2'- [{(2,2,2-trichloroethyl)oxy}carbonyl]-7-epi-Δ 12 ' 13 -iso-taxol, the title compound is prepared. Following the general procedures of Examples 15 and 11 but using appropriate metal salts, such as sodium or potassium bromide and sodium or potassium iodide or sodium or potassium azide, in the procedure of Example 15, the following compounds are prepared: 7-Deoxy-7α-bromo-Δ 12,13 -iso-taxol; 7-Deoxy-7β-bromo-Δ 12,13 -iso-taxol; 7-Deoxy-7α-iodo-Δ 12 13 -iso-taxol; 7-Deoxy-7β-iodo-Δ 12,13 -iso-taxol; 7-Deoxy-7α-azido-Δ 12,13 -iso-taxol; and 7-Deoxy-7β-azido-Δ 12 ' 13 -iso-taxol. Compounds of Formula xii wherein R 6 is H, R 8 is methyl and R 7 is a chlorine, bromine or iodine atom can also prepared by reaction of an appropriately protected precursor (e.g., I wherein R x = -C 6 H 5 ; 1^ = -NHC(O)C 6 H 5 ; R 3 = H; R 4 = - OTROC; R 5 = H; R 3 o = -OCOCH 3 ; and X, = OH) with (C 6 H e ) 3 P X 2 ; (C 6 H 5 ) 3 P/CX 4 ; or (C g H g O^P/X j ) following, for example, the numerous examples and experimental conditions described in Castro, B.R., Organic Reactions. 1983, 29, pp 1-162. Derivatives of the 7-deoxy-7-halo-Δ 12 ' 13 -iso-taxols in which the 2'-hydroxyl group is esterified are prepared directly from the desired 7-deoxy-7-halo-Δ 12 ' 13 -iso-taxol by methods which are given in: Mathew, A. E., et.al., J. Med. Chem., 1992, 35, 145; U.S. Patent 4,960,790; U.S. Patent 4,942,184; U.S. Patent 5,059,699. Following the general procedures of Mathew et al. (see, e.g., U.S. Patent 4,960,790, 4,924,184 and 5,059,699) but substituting the appropriate 7-deoxy-7-halo- Δ 12,13 -iso-taxol analog, the following compounds are prepared: 2'-succinyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(β-alanyl)-7-deoxy-7-fluoro-Δ 1 ' 13 -iso-taxol formate; 2'-glutaryl-7-deoxy-7-fluoro-Δ 12 13 -iso-taxol; 2'-[-C(O)(CH 2 ) 3 C(O)NH(CH 2 ) 3 N(CH 3 ) 2 ]-7-deoxy-7-fluoro-Δ 12 - 13 -iso-taxol; 2'-(β-sulfopropionyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(2-sulfoethylamido)succinyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(3-sulfopropylamido)succinyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(triethylsilyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(t-butyldimethylsilyl)-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(N,N-diethylaminopropionyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(N,N-dimethylglycyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(glycyl)-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(L-alanyl)-7-deoxy-7-fluoro-Δ 1 ' 13 -iso-taxol; 2'-(L-leucyl)-7-deo3ςy-7-fluoro-Δ 1 ' 13 -iso-taxol; 2'-(L-isoleu(_yl)-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(L-valyl)-7-deoxy-7-fluoro-Δ 1213 -iso-taxol; 2'-(L-phenylalanyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(L-prolyl)-7-deoxy-7-fluoro-Δ 1 13 -iso-taxol; 2'-(L-lysyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(L-glutamyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(L-arginyl)-7-deoxy-7-fluoro-Δ 1 ,13 -iso-taxol; 7-deoxy-7-fluoro-Δ 1213 -iso-taxotere; 2'-succinyl-7-deoxy-7-chloro-Δ 12,13 -iso-taxol; 2'-(β-alanyl)-7-deoxy-7-chloro-Δ 12,13 -iso-taxol formate; 2'-glutaryl-7-deoxy-7-chloro-Δ 12,13 -iso-taxol; 2'-[-C(O)(CH 2 ) 3 C(O)NH(CH 2 ) 3 N(CH 3 ) 2 ]-7-deoxy-7-chloro-Δ 12 ' 13 -iso-taxol; 2'-(β-sulfopropionyl)-7-deoxy-7-chloro-Δ 12,13 -iso-taxol; 2'-(2-sulfoethylamido)succinyl-7-deoxy-7-chloro-Δ 12 ' 13 -iso-taxol; 2'-(3-sulfopropylamido)succinyl-7-deoxy-7-chloro-Δ 1 ' 13 -iso-taxol; 2'-(triethylsilyl)-7-deoxy-7-chloro-Δ 1 ' 13 -iso-taxol; 2'-(t-butyldimethylsilyl)-7-deoxy-7-chloro-Δ 12,13 -iso-taxol; 2'-(N,N-diethylaminopropionyl)-7-deoxy-7-chloro-Δ 1 ,13 -iso-taxol; 2'-(N,N-dimethylglycyl)-7-deoxy-7-chloro-Δ 1213 -iso-taxol; 2'-(glycyl)-7-deoxy-7-chloro-Δ 12,13 -iso-taxol; 2'-(L-alanyl)-7-deoxy-7-chloro-Δ 12,13 -iso-taxol; 2'-(L-leucyl)-7-deoxy-7-chloro-Δ 12,13 -iso-taxol; 2'-(L-isoleucyl)-7-deoxy-7-chloro-Δ 12,13 -iso-taxol; 2'-(L-valyl)-7-deoxy-7-chloro-Δ 12,13 -iso-taxol; 2'-(L-phenylalanyl)-7-deoxy-7-chloro-Δ 12 ' 13 -iso-taxol; 2'-(L-prolyl)-7-deoxy-7-chloro-Δ 12,13 -iso-taxol; 2'-(L-lysyl)-7-deoxy-7-chloro-Δ 12,13 -iso-taxol; 2'-(L-glutamyl)-7-deoxy-7-chloro-Δ 12,13 -iso-taxol; 2'-(L-arginyl)-7-deoxy-7-chloro-Δ 12 ' 13 -iso-taxol; 7-deoxy-7-chloro-Δ 12,13 -iso-taxotere; 2'-succinyl-7-deoxy-7-bromo-Δ 1213 -iso-taxol; 2'-(β-alanyl)-7-deoxy-7-bromo-Δ 12,13 -iso-taxol formate: 2'-glutaryl-7-deoxy-7-bromo-Δ 12,13 -iso-taxol; 2'-[-C(O)(CH 2 ) 3 C(O)NH(CH 2 ) 3 N(CH 3 ) 2 ]-7-deox -7-bromo-Δ 12 ' 13 -iso-taxol; 2'-(β-sulfopropionyl)-7-deoxy-7-bromo-Δ 12,13 -iso-taxol; 2'-(2-sulfoethylamido)succinyl-7-deoxy-7-bromo-Δ 1213 -iso-taxol; 2'-(3-sulfopropylamido)succinyl-7-deoxy-7-bromo-Δ 12 ' 13 -iso-taxol; 2'-(triethylsilyl)-7-deoxy-7-bromo-Δ 12,13 -iso-taxol; 2'-(t-butyldimethylsilyl)-7-deoxy-7-bromo-Δ 1 ' 13 -iso-taxol; 2'-(N,N-diethylaminopropionyl)-7-deoxy-7-bromo-Δ 12,13 -iso-taxol; 2'-(N,N-dimethylglycyl)-7-deoxy-7-bromo-Δ 12 ' 13 -iso-taxol; 2'-(glycyl)-7-deoxy-7-bromo-Δ 12 ' 13 -iso-taxol; 2'-(L-alanyl)-7-deoxy-7-bromo-Δ 12 ' 13 -iso-taxol; 2'-(L-leucyl)-7-deoxy-7-bromo-Δ 1 ,13 -iso-taxol; 2'-(L-isoleucyl)-7-deoxy-7-bromo-Δ 1 ,13 -iso-taxol; 2'-(L-valyl)-7-deoxy-7-bromo-Δ 1 ' 13 -iso-taxol; 2'-(L-phenylalanyl)-7-deoxy-7-bromo-Δ 12 ' 13 -iso-taxol; 2'-(L-prolyl)-7-deoxy-7-bromo-Δ 12 ' 13 -iso-taxol; 2'-(L-lysyl)-7-deoxy-7-bromo-Δ 1 ,13 -iso-taxol; 2'-(L-glutamyl)-7-deoxy-7-bromo-Δ 12,13 -iso-taxol; 2'-(L-arginyl)-7-deoxy-7-bromo-Δ 12,13 -iso-taxol; 7-deoxy-7-bromo-Δ 12,13 -iso-taxotere; 2'-succinyl-7-deoxy-7-iodo-Δ 12 ' :l3 -iso-taxol; 2'-(β-alanyl)-7-deoxy-7-iodo-Δ 12 ' 13 -iso-taxol formate; 2'-glutaryl-7-deoxy-7-iodo-Δ 1 ,13 -iso-taxol; 2'-[-C(O)(CH 2 ) 3 C(O)NH(CH 2 ) 3 N(CH 3 ) 2 ]-7-deoxy-7-iodo-Δ 12 ' 13 -iso-taxol; 2'-(β-sulfopropionyl)-7-deoxy-7-iodo-Δ 12,13 -iso-taxol; 2'-(2-sulfoethylamido)succinyl-7-deoxy-7-iodo-Δ 12 ' 13 -iso-taxol; 2'-(3-sulfopropylamido)succinyl-7-deoxy-7-iodo-Δ 12,13 -iso-taxol; 2'-(triethylsilyl)-7-deoxy-7-iodo-Δ 12,13 -iso-taxol; 2'-(t-butyldimethylsilyl)-7-deoxy-7-iodo-Δ 12,13 -iso-taxol; 2'-(N,N-diethylaminopropionyl)-7-deoxy-7-iodo-Δ 12,13 -iso-taxol; 2'-(N,N-dimethylglycyl)-7-deoxy-7-iodo-Δ 12,13 -iso-taxol; 2'-(glycyl)-7-deoxy-7-iodo-Δ 12,13 -iso-taxol; 2'-(L-alanyl)-7-deoxy-7-iodo-Δ 1213 -iso-taxol; 2'-(L-leucyl)-7-deoxy-7-iodo-Δ 1213 -iso-taxol; 2'-(L-isoleucyl)-7-deoxy-7-iodo-Δ 12 ' 13 -iso-taxol; 2'-(L-valyl)-7-deoxy-7-iodo-Δ 12 ' :l3 -iso-taxol; 2'-(L-phenylalanyl)-7-deoxy-7-iodo-Δ 1213 -iso-taxol; 2'-(L-prolyl)-7-deoxy-7-iodo-Δ 12 ' 13 -iso-taxol; 2'-(L-lysyl)-7-deoxy-7-iodo-Δ 12>13 -iso-taxol; 2'-(L-glutamyl)-7-deoxy-7-iodo-Δ 1213 -iso-taxol; 2'-(L-arginyl)-7-deoxy-7-iodo-Δ 1 ' 13 -iso-taxol; 7-deoxy-7-iodo-Δ 12 ' 13 -iso-taxotere; and pharmaceutically acceptable salts thereof when the compound contains either an acidic or basic functional group. Example 138 Emulsion Formulation of N-Debenzoyl-N-(i-butyl)aminocarbonyl-7- deoxy-7β,8β-methano-12,13-isotaxol (Cpd 36) A 14.5 mg sample of N-Debenzoyl-N-(£-butyl)aminocarbonyl-7-deoxy-7β,8β- methano-12,13-isotaxol (Cpd 36) is weighed and added to 0.5 gm of water with probe sonication. An aliquot of 0.5 gm oil (Miglyol 810) is added with mixing for four hours. An aliquot of an aqueous phase containing phosphohpid (egg lecithin) and glycerine is then added to the oil-drug mixture to yield a 20% oil emulsion containing 12.5 mg/gm phosphohpid, 22.5 mg gm glycerine, and 6 mg/gm drug. The mixture is prehomogenized by sonication prior to final emulsification with an EmulsiFlex B3. A physically stable emulsion with mean particle size of 240 nm (measured by light scattering) results. Example 139 Emulsion Formulation of N-Debenzoyl-N-(£-butyl)aminocarbonyl-7- deoxy-Δ 6 ' 7 -12,13-isotaxol (Cpd 38) A 70 mg sample of N-Debenzoyl-N-(£-butyl)aminocarbonyl-7-deoxy-Δ 6,7 -12,13- isotaxol (Cpd 38) is weighed and added to 1 gm water with probe sonication. An aliquot of 4.0 gm of oil (Miglyol 810) is added with mixing for 36 hours. The oil/water/drug mixture is centrifuged and oil phase removed, assayed and split into three different aliquots, which are then diluted with oil to 3.4, 6.9 and 13.8 mg drug/gm oil. Ahqouts of an aqueous phase containing phosphohpid (egg lecithin) and glycerine are then added to the oil-drug mixtures to yield a 20% oil emulsion containing 12.5 mg/gm phosphohpid, 22.5 mg/gm glycerine, and either 0.7, 1.4, or 2.8 mg gm drug. The mixture is prehomogenized by sonication prior to final emulsification with an EmulsiFlex B3. Physically stable emulsions with mean particle sizes of 200-215 nm (measured by hght scattering) is obtained. Procedures for the preparation of Δ 12,13 -iso-taxol 7-ethers. Preparation 1: Preparation of 7-(O-methyl)-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)-N-Boc-2- (2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxylic acid ester Sodium hydride (55% dispersion in mineral oil, 43 mg, 1 mmol) is washed three times, by decantation, with anhydrous n-hexane. A solution of Δ 12,13 -iso- baccatin III- 13 (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (10a, 1 mmol) in anhydrous DMF (6 mL) is add at 0° C and the resulting mixture stirred at rt for 30 min. The resulting mixture is then treated with methyl iodide (82 μL, 1.3 mmol) and stirred for an additional 60 min. The reaction is then quenched with 5% aqueous ammonium chloride solution and extracted with ether. The organic layer is dried (MgSO 4 ) and the solvent evaporated under vacuum. The residue is purified by chromatography over silica gel, leaving 7-(O-methyl)-Δ 12,13 -iso-baccatin III-13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4- phenyl-5-oxazolidinecarboxylic acid ester. See: Banfi, L.; Bernardi, A.; Columbo, L.; Gennari, C; Scolastico, C. J. Org. Chem. 1984, 49, 3784. Preparation 2: Preparation of 7-(O-methyl)-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)-N-Boc-2- (2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester Δ 12 - 13 -Iso-baccati III-13 (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (10a, 1 mmol), methyl iodide (1.2 mmol), silver tetrafluoroborate (1.2 mmol) and silver carbonate (2 mmol) are added to acetonitrile (5 mL) and the mixture stirred at rt for 48 hr. The reaction is then diluted with ethyl acetate (20 mL) and filtered. The filtrate is extracted with water, 5% aqueous bicarbonate and dried (MgSO 4 ) and the solvent evaporated under vacuum. The residue is purified by chromatography over sihca gel, leaving 7-(O-methyl)-Δ 12,13 -iso- baccatin III-13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester. See: Bhatia, S. K.; Hajdu, J. Tetrahedron Lett. 1987, 28, 271. Preparation 3 Preparation of 7-(O-methyl)-Δ x213 -iso-baccatin III-13-(4S,5R)-N-Boc-2- (2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester Δ 12,13 -Iso-baccatin III- 13 (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazohdinecarboxyhc acid ester (10a, 1 mmol), 2,6-di-t-butyl pyridine (2.3 mmol) and mercuric cyanide (5.8 mg, 0.023 mmol) is dissolved in methylene chloride (4.5 mL) and the solution treated with methyl trifluoromethane sulfonate (0.24 mL, 2.2 mmol). The solution is heated under reflux for 50 hr, then treated with methanol (0.2 mL). The reaction is then evaporated under vacuum and the residue purified by chromatography over sihca gel, leaving 7-(O-methyl)-Δ 12 ' 13 -iso-baccatin III- 13- (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxylic acid ester. See: J. Carbohyd. Chem. 1986, 5, 115. Deprotection of Methyl ethers Preparation 4 Preparation of 7-(O-methyl)-13-(N-Boc-β-phenyl baccatin III (41) 7-(O-methyl)-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)- 4-phenyl-5-oxazolidinecarboxylic acid ester (1 mmol) is stirred at RT under nitogen in (80-20) acetic acid-water (4 mL). The reaction is followed by TLC and is found to be complete in 24 hours. The reaction is then freeze-dried. The crude product is purified by chromatography over sihca gel to give 7-(O-methyl)-13-(N-Boc-β-phenyl isoserinyl)-Δ 1213 -iso-baccatin III. Allyl ether Syntheses Preparation 5 Preparation of 7-(O-allyl)-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)-N-Boc-2- (2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboχylic acid ester A solution of Δ 1213 -iso-baccatin 111-13 (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)- 4-phenyl-5-oxazolidinecarboxylic acid ester (10a, 1 mmol) in methylene chloride is treated with allyl trichloroacetimidate (2 mmol) and trifluoromethane sulfonic acid (25 μL) and the reaction stirred 48 hours at room temperature. The reaction is filtered and the filtrate washed with 5% aqueous sodium bicarbonate solution. The organic layer is then dried (MgSO 4 ) and the solvent evaporated under vacuum. The residue is purified by chromatography over sihca gel, leaving 7-(O-allyl)-Δ 12,13 -iso- baccatin III-13-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester. See: Wessel H-P.; Iverson, T.; Bundle, D. R. J. Chem. Soc. Perkin Trans. I. 1985, 2247. Preparation 6 Preparation of 7-(O-allyl)-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)-N-Boc-2- (2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester Sodium hydride (55% dispersion in mineral oil, 43 mg, 1 mmol) is washed three times, by decantation, with anhydrous n-hexane. A solution of Δ 12,13 -iso- baccatin III- 13 (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5- oxazolidinecarboxylic acid ester (10a, 1 mmol) in anhydrous DMF (6 mL) is add at 0° C and the resulting mixture stirred at rt for 30 min. The resulting mixture is then treated with allyl bromide (1.3 mmol) and stirred for an additional 60 min. The reaction is then quenched with 5% aqueous ammonium chloride solution and extracted with ether. The organic layer is dried (MgSO 4 ) and the solvent evaporated under vacuum. The residue is purified by chromatography over sihca gel, leaving 7-(O-allyl)-Δ 1 - 13 -iso-baccatin IIM3-(4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl- 5-oxazolidinecarboxylic acid ester. See: Kloosterman, M.; de Nijs, M. P.; van Boom, J. H. J. Carbohyd. Chem. 1986, 5, 2247. Preparation 7 Preparation of 7-(O-allyl)-Δ 12 ' 13 -iso-baccatin III-13-(4S,5R)-N-Boc-2- (2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester Under an argon atmosphere, tris(dibenzylidineacetone)dipalladium (0.025 mmol), and l,4-bis(biphenylphosphino)butane (0.1 mmol) are added to tetrahydrofuran (2 mL). This solution is treated with Δ^'^-iso-baccatin III- 13 (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxyhc acid ester (10a, 1 mmol) and allyl ethyl carbonate in tetrahydrofuran (2 mL). After stirring at 65° C for 4 h, the solvent is evaporated under vacuum. The residue is purified by chromatography over sihca gel, leaving 7-(O-allyl)-Δ 12,13 -iso-baccatin III-13-(4S,5R)- N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazohdinecarboxylic acid ester. See: Lakhmiri, R.; Lhoste, P.; Sinou, D. Tetrahedron Lett. 1989, 30, 4669. Deprotection of 7-(O-allyl)-Δ 1213 -iso-baccatin III-13-(4S,5R)-N-Boc-2-(2,4- dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid ester The protected allyl ethers may be deprotected to 7-(O-allyl)-13-(N-Boc-β- phenyl isoserinyl)-Δ 12,13 -iso-baccatin III in the same manner as 7-(O-methyl)-13-(N- Boc-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III is deprotected in preparation 4. Following the procedure described in Carboni, J. M.; Farina, V.; Srinivasa, R.; Hauck, S. I.; Horowitz, S. B.; Ringel, I. J. Med. Chem. 1993, 36, 513 but using the appropriate starting material of examples 5, 7, 26 and Δ 12,13 -iso-taxol the following 7- ester Δ 12,13 -iso-taxol analogs are prepared: 7-acetyl-Δ 12,13 -iso-taxol; 7-acetyl-Δ 12,13 -iso-taxotere; 7,10-diacetyl-Δ 12 ' 13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-acetyl-Δ 1213 -iso-taxol; 7-propionyl-Δ 12,13 -iso-taxol; 7-propionyl-Δ 12,13 -iso-taxotere; 7-propionyl-10-acetyl-Δ 12,13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-propionyl-Δ 12 ' 13 -iso-taxol; 7-butyryl-Δ 12,13 -iso-taxol; 7-butyryl-Δ 12,13 -iso-taxotere; 7-butyryl-10-acetyl-Δ 1213 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-butyryl-Δ 12 ' 13 -iso-taxol; 7-benzoyl-Δ 12,13 -iso-taxol; 7-benzoyl-Δ 1 13 -iso-taxotere; 7-benzoyl-10-acetyl-Δ 1 13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-benzoyl-Δ 12,13 -iso-taxol; 7-(4-methylbenzoyl)-Δ 12,13 -iso-taxol; 7-(4-methylbenzoyl)-Δ 1 ,13 -iso-taxotere; 7-(4-methylbenzoyl)- 10-acetyl-Δ 12 ' 13 -iso-taxotere; and N-debenzoyl-N-t-butylaminocarbonyl-7-(4-methylbenzoyl)-Δ 1 ,13 -iso-taxol. Following the procedure described in Denis, J-N.; Greene, A. E.; Guenard, D.; Gueritte-Vogelein, F.; Mangatal, L.; Potier, P. J. Am. Chem. Soc. 1988, 110, 5917 but using the appropriate starting material of examples 5, 7, 26 and Δ 12,13 -iso-taxol the following 7-silyl ether Δ 1213 -iso-taxol analogs are prepared: 7-(O-trimethylsilyl)-Δ 12 - 13 -iso-taxol; 7-(O-trimethylsilyl)-Δ 1213 -iso-taxotere; 7-(O-trimethylsilyl)-10-diacetyl-Δ 1 ' 13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-(O-trimethylsilyl)-Δ 12,13 -iso-taxol; 7-(O-triethylsilyl)-Δ 12 ' 13 -iso-taxol; 7-(O-triethylsilyl)-Δ 12,13 -iso-taxotere; 7-(O-triethylsilyl)-10-diacetyl-Δ 12,13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-(O-triethylsilyl)-Δ 12,13 -iso-taxol; 7-(O-triisopropylsilyl)-Δ 12 ' 13 -iso-taxol; 7-(O-triisopropylsilyl)-Δ 12,13 -iso-taxotere; 7-(O-triisopropylsilyl)-10-diacetyl-Δ 12,13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-(O-triisopropylsilyl)-Δ 12,13 -iso-taxol; 7-(O-t-butyldimethylsilyl)-Δ 12 ' 13 -iso-taxol; 7-(O-t-butyldimethylsilyl)-Δ 12 - 13 -iso-taxotere; 7-(O-t-butyldimethylsilyl)-10-diacetyl-Δ 12 ' 13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-(O-t-butyldimethylsilyl)-Δ 12,13 -iso-taxol; 7-(O-ethoxymethyl)-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III; and 7-(O-ethoxymethyl)-13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyD-Δ 12 ' 13 - iso-baccatin III. Following the procedure described in Denis, J-N.; Greene, A. E.; Guenard, D.; Gueritte-Vogelein, F.; Mangatal, L.; Potier, P. J. Am. Chem. Soc. 1988, 110, 5917 but using the appropriate starting material of examples 84 and 85 and Δ 12,13 -10-DAD-iso- taxol 94 the following 7-silyl ether Δ 12,13 -iso-taxol analogs are prepared: 7-tO-2-(3-methylbutyl)dimethylsilyl]-Δ 12 ' 13 -iso-taxol; 7-[O-2-(3-methylbutyl)dimethylsilyl]-Δ 12 ' 13 -iso-taxotere; 7-[O-2-(3-methylbutyl)dimethylsilyl]-10-diacetyl-Δ 12>13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-[O-2-(3-methylbutyl)dimethyl-silyl]- Δ 12 ' 13 -iso-taxol; 7-(O-tri-n-butylsilyl)-Δ 12 ' 13 -iso-taxol; 7-(O-tri-n-bulylsilyl)-Δ 12 ' 13 -iso-taxotere; 7-(O-tri-n-butylsilyl)-10-diacetyl-Δ 12,13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-(O-tri-n-butylsilyl)-Δ 12,13 -iso-taxol; 7-(O-cyclohexyldimethylsilyl)-Δ 12 ' 13 -iso-taxol; 7-(O-cyclohexyldimethylsilyl)-Δ 12,13 -iso-taxotere; 7-(O-cyclohexyldimethylsilyl)-10-diacetyl-Δ 12,13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-(O-cyclohexyldimethylsilyl)-Δ 12,13 -iso- taxol; 7-(O-i-propyldiethylsilyl)-Δ 12 13 -iso-taxol; 7-(O-i-propyldiethylsilyl)-Δ 12,13 -iso-taxotere; 7-(O-i-propyldiethylsilyl)-10-diacetyl-Δ 12 ' 13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-(O-i-propyldiethylsilyl)-Δ 12,13 -iso-taxol; 7-(O-cycloheptyldimethylsilyl)-Δ 12,13 -iso-taxol; 7-(O-cycloheptyldimethylsilyl)-Δ 12,13 -iso-taxotere; 7-(O-cycloheptyldimethylsilyl)-10-diacetyl-Δ 12,13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-(O-cycloheptyldimethylsilyl)-Δ 12 ' 13 -iso- taxol. Following the procedure described in Denis, J-N.; Greene, A. E.; Guenard, D.; Gueritte-Vogelein, F.; Mangatal, L.; Potier, P. J. Am. Chem. Soc. 1988, 110, 5917 but using the appropriate starting material of examples 84 and 85 and 10-DAB-iso-taxol 94 the following 7-silyl ether taxol analogs are prepared: 7-[O-2-(3-methylbutyl)dimethylsilyl]-taxol; 7-[O-2-(3-methylbutyl)dimethylsilyl]-taxotere; 7-[O-2-(3-methylbutyl)dimethylsilyl]-10-diacetyl-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-[O-2-(3-methylbutyl)dimethyl-silyl]- taxol; 7-(O-tri-n-butylsilyl)-taxol; 7-(O-tri-n-butylsilyl)-taxotere; 7-(O-tri-n-butylsilyl)-10-diacetyl-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-(O-tri-n-butylsilyl)taxol; 7-(O-cyclohexyldimethylsilyl)-taxol; 7-(O-cyclohexyldimethylsilyl)-taxotere; 7-(O-cyclohexyldimethylsilyl)-10-diacetyl-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-(O-cyclohexyldimethyl-silyl)taxol 7-(O-i-propyldiethylsilyl)taxol; 7-(O-i-propyldiethylsilyl)taxotere; 7-(O-i-propyldiethylsilyl)-10-diacetyl-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-(O-i-propyldiethylsilyl)taxol; 7-(O-cycloheptyldimethylsilyl)taxol; 7-(O-cycloheptyldimethylsilyl)taxotere; 7-(O-cycloheptyldimethylsilyl)- 10-diacetyl-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-(O-cycloheptyldimethylsilyl)~taxol. Following the procedure described in Magri, N. F.; Kingston, D. G. I.; Jitrangsri, C; Piccariello, T. J. Org. Chem. 1986, 51, 3239 but using the appropriate starting material of examples 5, 7, 26 and Δ 12,13 -iso-taxol the following 7-carbonate Δ^'^-iso-taxol analogs are prepared: 7-(O-methylcarbonate)-Δ 12 ' 13 -iso-taxol; 7-(O-methylcarbonate)-Δ 12,13 -iso-taxotere; 7-(O-methylcarbonate)-10-acetyl-Δ 12,13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-(O-methylcarbonate)-Δ 12,13 -iso-taxol; 7-(O-ethylcarbonate)-Δ 12,13 -iso-taxol; 7-(O-ethylcarbonate)-Δ 12,13 -iso-taxotere; 7-(O-ethylcarbonate)-10-acetyl-Δ 12,13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-(O-ethylcarbonate)-Δ 12,13 -iso-taxol; 7-(O-propylcarbonate)-Δ 12 ' 13 -iso-taxol; 7-(O-propylcarbonate)-Δ 12,13 -iso-taxotere; 7-(O-propylcarbonate)- lO-acetyl-Δ^'^-iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-(O-propylcarbonate)-Δ 12,13 -iso-taxol; 7-[O-(2,2,2-trichloroethyl)carbonate]-Δ 12,13 -iso-taxol; 7-[O-(2,2,2-trichloroethyl)carbonate]-Δ 12,13 -iso-taxotere; 7-[O-(2,2,2-trichloroethyl)carbonate]-10-acetyl-Δ 12 13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-[O-(2,2,2-trichloroethyl)carbonate]- Δ 12 - 13 -iso-taxol; 7-[O-(2,2-dichloroethyl)carbonate]-Δ 12,13 -iso-taxol; 7-[O-(2,2-dichloroethyl)carbonate]-Δ 1 ' :l3 -iso-taxotere; 7-[O-(2,2-dichloroethyl)carbonate]-10-acetyl-Δ 12 ' 13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-[O-(2,2-dichloroethyl)carbonate]-Δ :2,13 - iso-taxol; 7-[O-(2-chloroethyl)carbonate]-Δ 12,13 -iso-taxol; 7-[O-(2-chloroethyl)carbonate]-Δ 12,13 -iso-taxotere; 7-[O-(2-chloroethyl)carbonate]- lO-acetyl-Δ^'^-iso-taxotere; and N-debenzoyl-N-t-butylaminocarbonyl-7-[O-(2-chloroethyl)carbonate]-Δ 12,13 -iso- taxol. Following the procedure described in EP 524 093 Al but using the appropriate starting material of examples 5, 7, 26 and Δ^'^-iso-taxol the foUowing 7- carbamate Δ 12 13 -iso-taxol analogs are prepared: 7-[O-(N-methyl)carbamate]-Δ 12 ' 13 -iso-taxol; 7-[O-(N-methyl)carbamate]-Δ 12 ' 13 -iso-taxotere; 7-[O-(N-methyl)carbamate]-10-acetyl-Δ 12,13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-[O-(N-methyl)carbamate]-Δ 12,13 -iso- taxol; 7-[O-(N,N-dimethyl)carbamate]-Δ 12 - 13 -iso-taxol; 7-[O-(N,N-dimethyl)carbamate]-Δ 12,13 -iso-taxotere; 7-tO-(N,N-dimethyl)carbamate]-10-acetyl-Δ 12,13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-[O-(N,N-dimethyl)carbamate]-Δ 12,13 -iso- taxol; 7-[O-(N-ethyl)carbamate]-Δ 12,13 -iso-taxol; 7-[O-(N-ethyl)carbamate]-Δ 12,13 -iso-taxotere; 7-[O-(N-ethyl)carbamate]-10-acetyl-Δ 12,13 -iso-taxotere; N-debenzoyl-N-t-butylaminocarbonyl-7-tO-(N-ethyl)carbamate]-Δ 12,13 -iso-taxol; 7-(O-morphohnocarbonyl)-Δ 12,13 -iso-taxol; 7-(O-morphohnocarbonyl)-Δ 12,13 -iso-taxotere; 7-(O-morphohnocarbonyl)- lO-acetyl-Δ^ so-taxotere; and N-debenzoyl-N-t-butylaminocarbonyl-7-(O-morphohnocarbonyl)-Δ 12,13 -iso-taxol. Following the procedure described in examples 36 and 38 but using the appropriate starting material of examples 5, 7, 26 and Δ^ so-taxol the foUowing 7- carbamate Δ 12,13 -iso-taxol analogs are prepared: 7-(O-methyl)-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III; 7-(O-methyl)-13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-Δ 12 ' 13 -iso- baccatin III; 7-(O-ethyl)- 13-(N-Boc-β-phenyl III; 7-(O-ethyl)-13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III; 7-(O-propyl)- 13-(N-Boc-β-phenyl III; 7-(O-propyl)-13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-Δ 12,13 -iso- baccatin III; 7-(O-aUyl)-13-(N-Boc-β-phenyl III; 7-(O-aUyl)- 13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-Δ 12 ' 13 -iso-baccatin πi; 7-(O-benzyl)-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III; 7-(O-benzyl)-13-(N-(t-butylaminocarbonyl)-β-phenyl baccatin III; 7-(O-methoxymethyl)-13-(N-Boc-β-phenyl isoserinyD-Δ^'^-iso-baccatin III; 7-(O-methoxymethyl)-13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-Δ 12,13 - iso-baccatin III; 7-(O-methoxyethoxymethyl)-13-(N-Boc-β-phenyl III; . 7-(O-methoxyethoxymethyl)-13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)- Δ 1213 -iso-baccatin III; 7-(O-benzyloxymethyl)-13-(N-Boc-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III; 7-(O-benzyloxymethyl)-13-(N-(t-butylaminocarbonyl)-β-phenyhsoserinyl)-Δ 12,13 - iso-baccatin III; 7-[O-(2,2,2-trichloroethoxy)methyl)-13-(N-Boc-β-phenyl isoserinyl)-Δ 12 ' 13 -iso- baccatin III; 7-[O-(2,2,2-trichloroethoxy)methyl)-13-(N-(t-butylaminocarbonyl)-β- phenyhsoserinyD-Δ^'^-iso-baccatin III; 7-[O-(2,2,2-trichloroethoxy)methoxymethyl)-13-(N-Boc-β-phenyl isoserinyl)- Δ 12,13 -iso-baccatin III; and 7-[O-(2,2,2-trichloroethoxy)methoxymethyl)-13-(N-(t-butylaminocarbonyl)-β- phenyl III. Taxol and the other starting taxol analogs are known or can be readily prepared by known methods. See The Chemistry of Taxol, Pharmac. Ther., Vol 52, pp 1-34, 1991 as weU as: U.S. Patent Nos. 4,814,470; 4,857,653; 4,942,184; 4,924,011; 4,924,012; 4,960,790; 5,015,744; 5,059,699; 5,136,060; 5,157,049; 4,876,399; 5,227,400, 5,254,580 as weU as PCT Publication No. WO 92/09589, European Patent Application 90305845.1 (Publication No. A2 0 400 971), 89400935.6 (Pubhcation No. Al 0 366 841) and 90402333.0 (Publication No. 0 414 610 Al), 87401669.4 (Al 0 253 739), 92308608.6 (Al 0 534 708), 92308609.4 (Al 534 709), and PCT Pubhcation Nos. WO 91/17977, WO 91/17976, WO 91/13066, WO 91/13053 ah of which are incorporated herein by reference. The compounds of the invention can be formulated per se in pharmaceutical preparations or formulated in the form of pharmaceuticaUy acceptable salts thereof, particularly as nontoxic pharmaceuticaUy acceptable addition salts or acceptable basic salts. These salts can be prepared from those compounds of the invention which contain acidic or basic groups according to conventional chemical methods. NormaUy, the salts are prepared by reacting the free base or acid with stoichiometric amounts or with an excess thereof of the desired salt forming inorganic or organic acid in a suitable solvent or various combination of solvents. As an example, the free base can be dissolved in an aqueous solution of the appropriate acid and the salt recovered by standard techniques, for example, by evaporation of the solution. Alternatively, the free base can be dissolved in an organic solvent such as a lower alkanoyl, an ether, an alkyl ester, or mixtures thereof, for example, methanol, ethanol, ether, ethylacetate, an ethylacetate-ether solution, and the hke, whereafter it is treated with the appropriate acid to form the corresponding salt. The salt is recovered by standard recovery techniques, for example, by filtration of the desired salt on spontaneous separation from the solution or it can be precipitated by the addition of a solvent in which the salt is insoluble and recovered therefrom. The taxol derivatives of the invention can be utihzed in the treatment of cancers, due to their cytotoxic, antitumor activity. In addition the taxol derivatives of the present invention can be utilized in the treatment of arthritis, in particular rheumatoid arthiritis, see Arthritis & Rheumatism, 32, 839, 1994 and Nature, 368, 757 (1994) which are incorporated herein by reference. In addition the taxol derivatives of the present invention can be utihzed in preventing the restenosis of arteries following angioplasty. The new compounds are administrable in the form of tablets, piUs, powder mixtures, capsules, injectables, solutions, suppositories, emulsions, dispersions, food premix, and in other suitable form. The pharmaceutical preparation which contains the compound is conveniently admixed with a nontoxic pharmaceutical organic carrier or a nontoxic pharmaceutical inorganic carrier, usuaUy about 0.01 mg up to 2500 mg, or higher per dosage unit, preferably 50-500 mg. Typical of pharmaceutically acceptable carriers are, for example, mannitol, urea, dextrans, lactose, potato and maize starches, magnesium stearate, talc, vegetable oils, polyalkylene glycols, ethyl ceUulose, poly(vinylpyrrolidone), calcium carbonate, ethyl oleate, isopropyl myristate, benzyl benzoate, sodium carbonate, gelatin, potassium carbonate, silicic acid, and other conventionally employed acceptable carriers. The pharmaceutical preparation may also contain nontoxic auxiliary substances such as emulsifying, preserving, wetting agents, and the like as for example, sorbitan monolaurate, triethanolamine oleate, polyoxyethylene monostearate, glyceryl tripalmitate, dioctyl sodium sulfosuccinate, and the like. Exemplary of a typical method for preparing a tablet containing the active agents is to first mix the agent with a nontoxic binder such as gelatin, acacia mucilage, ethyl ceUulose, or the like. The mixing is suitably carried out in a standard V-blender and usually under anhydrous conditions. Next, the just prepared mixture can be slugged through conventional tablet machines and the slugs fabricated into tablets. The freshly prepared tablets can be coated, or they can be left uncoated. Representative of suitable coatings are the nontoxic coatings including sheUac, methylceUulose, carnauba wax, styrene-maleic acid copolymers, and the like. For oral administration, compressed tablets containing 0.01 milligram, 5 milligrams, 25 milligrams, 50 milligrams, 500 miUigrams, etc., up to 2500 milhgrams are manufactured in the hght of the above disclosure and by art known fabrication techniques weU known to the art and set forth in Remington's Pharmaceutical Science, Chapter 39, Mack Publishing Co., 1965. To formulate the tablet, the active compound, cornstarch, lactose, dicalcium phosphate and calcium carbonate are uniformly blended under dry conditions in a conventional V-blender until all the ingredients are uniformly mixed together. Next, the cornstarch paste is prepared as a 10% paste and it is blended with the just prepared mixture until a uniform mixture is obtained. The mixture is then passed through a standard hght mesh screen, dried in an anhydrous atmosphere and then blended with calcium stearate, and compressed into tablets, and coated if desired. Other tablets containing 10, 50, 100, 150 mgs, etc., are prepared in a like fashion. The foUowing Formulation I is an example of a tablet formulation comprising a compound of the invention. The manufacture of capsules containing 10 milligrams to 2500 milligrams for oral use consists essentiaUy of mixing the active compound with a nontoxic carrier and enclosing the mixture in a polymeric sheath, usually gelatin or the like. The capsules can be in the art known soft form of a capsule made by enclosing the compound in intimate dispersion within an edible, compatible carrier, or the capsule can be a hard capsule consisting essentiaUy of the novel compound mixed with a nontoxic solid such as talc, calcium stearate, calcium carbonate, or the like. Capsules containing 25 mg, 75 mg, 125 mg, and the like, of the novel compound, singularly or mixtures of two or more of the novel compounds are prepared, for example, as follows: The above ingredients are blended together in a standard blender and then discharged into commercially avaUable capsules. When higher concentrations of the active agent is used, a corresponding reduction is made in the amount of lactose. The compounds of the invention can also be freeze dried and, if desired, combined with other pharmaceutically acceptable excipients to prepare formulations suitable for parenteral, injectable administration. For such administration, the formulation can be reconstituted in water (normal, saline), or a mixture of water and an organic solvent, such as propylene glycol, ethanol, and the like. The dose administered, whether a single dose, multiple dose, or a daily dose, will of course, vary with the particular compound of the invention employed because of the varying potency of the compound, the chosen route of administration, the size of the recipient and the nature of the patient's condition. The dosage administered is not subject to definite bounds, but it wiU usually be an effective amount, or the equivalent on a molar basis of the pharmacologically active free form produced from a dosage formulation upon the metabolic release of the active drug to achieve its desired pharmacological and physiological effects. TypicaUy the compounds of the invention can be administered by intravenous injection at doses of 1-500 mg per patient per course of cancer treatment, preferable with doses of 20-200 mg, the exact dosage being dependent on the age, weight, and condition of the patient. An example of a suitable formulation for injection is using a solution of the compound of the invention in a mixture of polysorbate alcohol and dehydrated alcohol (e.g., 1:1) foUowed by dilution with 5% dextrose in water prior to infusion or injection. TypicaUy the compounds of the invention can be administered by oral administration at doses of 1-500 mg per patient per course of cancer treatment, preferable with doses of 20-600 mg, the exact dosage being dependent on the age, weight, and condition of the patient. The compounds of Formula I (including II, Ila, III, Ilia, IV, IVa, V, Va, and VI) are useful for the same cancers for which taxol has been shown active, including human ovarian tumors, mammary tumors, and malignant melanoma, lung tumors, gastric tumors, colon tumors, head and neck tumors, and leukemia. See, e.g., the chnical pharmacology of taxol is reviewed by Eric K. Rowinsky and Ross C. Donehower, The Chnical Pharmacology and Use of Antimicrotubule Agents in Cancer Chemotherapeutics, Pharmac. Ther., Vol 52, pp 35-84, 1991. Chnical and preclinical studies with taxol are reviewed by William J. Slichenmyer and Daniel D. Von HofF, Taxol: A New and Effective Anti-cancer Drug, Anti-Cancer Drugs, Vol. 2, pp 519-530, 1991. The biological activity of the 7-deoxy-7β,8β-methano-iso-taxol compounds (Formula II) of the invention has been confirmed using weU known procedures. For example, comparison of the cytotoxicity of Cpd 17 with taxol itself in L1210 mouse leukemia carcinoma ceUs in culture indicated that the IC 90 (90% growth inhibitory concentration) for 7-deoxy-7β,8β-methano-iso-taxol was 0.017 micrograms/ml and for taxol was 0.018 micrograms/ml. In an in vitro tubulin polymerization assay, conducted after the manner of F. Gaskin, et al., J. Mol. Biol.. 89:737, 1974, 7-deoxy- 7β,8β-methano-taxol was able to induce tubuhn polymerization in vitro at 20°C in a manner very siπύlar to taxol. The biological activity of 7-deoxy-7-halo-iso-taxol compounds (Formula III) of the invention has been confirmed using well known procedures. For example, comparison of the cytotoxicity of Cpd 16 with taxol itself in A2780 (human ovarian carcinoma) ceUs in culture indicated that the IC 90 (90% growth inhibitory concentration) for 7-deoxy-7-fluoro-Δ 12,:l3 -iso-taxol was 0.0029 micrograms/ml and for taxol was 0.017 micrograms/ml. The biological activity of the compounds of this invention has been further confirmed using weU known procedures against A2780 human ovarian carcinoma and the results set forth in Table II. The results were obtained using standard well known procedure (Perez, R.P.; O'Dwyer, P.J.; Handel, L.M.; Ozols, R.F.; Hamilton, T.C. Int. J. Cancer 1991, 48, 265, Alley, M.C.; Scudiero, D.A.; Monks, A.; Hursey, MX.; Czerwinski, M.J.; Fine, D.L. et al.; Cancer Res. 1988, 48:589). The biological activity of the compounds of this invention has been further confirmed using weU known procedures against L1210 leukemia and the results set forth in Table I. The results were obtained using standard weU known procedure (Li, L.H.; Kuentzel, S.L.; Murch, L.L.; Pschigoga, L.M.; and W.C. Krueger, "Comparative biological and biochemical effects of nogalamycin and its analogs on L1210 leukemia," Cancer Res. 39:4816-4822 (1979)). The results are expressed as an IC 50 which is the drug concentration required to inhibit cell proliferation to 50% of that of untreated control cells. Lower numbers indicated greater activity. It is well known that many human tumors are resistant to chemotherapeutic agents due to a phenomenon caUed multidrug resistance (MDR). Cells that are multidrug resistant are resistant to a wide variety of drugs including taxol, taxotere and other chemotherapeutic agents such as doxorubicin, vinblastine and etoposide. This multidrug resistance undoubtedly contributes to the limited success of some therapeutic agents including taxol and taxotere. Therefore, development of a taxol or taxotere analog that could circumvent this multidrug resistance, and could kill multidrug resistant (MDR) ceUs more efficiently than taxol or taxotere would be expected to provide a better efficacy against multidrug resistant tumors in the clinic. Several of the compounds described in this patent have been tested for their ability to circumvent multidrug resistance and il multidrug resistant ceUs. An i vitro assay to compare the killing ability of taxol analogs on the non- multidrug resistant (non-MDR) ceU line, KB-3-1 as compared to the MDR ceU line, KB-Vl, by taxol analogs (Shen et al., 1986, J. Biol. Chem. 261:7762; Mossman, T. J., 1983, Immunol. Methods 65:55-63; Abraham et al., 1994, Cancer Res. 54:5889). KB- Vl expresses high levels of the drug efflux pump, P-glycoprotein (pl70)(Shen et al., 1986, ibid.) has been used. This overexpression of the P-glycoprotein pump is thought to be the major source of the drug resistance in these cells (Endicott and Ling, 1989, Ann. Rev. Biochem. 58:137). The assays were performed in order to assess whether any of the analogs can bypass the P-glycoprotein drug efflux pump and can ltill ceUs that are multidrug resistant. The IC50 (inhibiting dose) for KB-3- 1 and KB-Vl was determined and the ratio of the IC50 for KB-Vl to that of KB-3-1 was also presented. IC50 measures the amount of drug required to kUl 50% of the ceUs. A large ratio (IC50 KB-V1/IC50 KB-3-1) shows that a high concentration of the test compound is required to kiU resistant ceUs as compared to the amount required to kiU the drug sensitive cells. Compounds with large ratios do not efficiently circumvent the drug resistance mechanism in the resistant ceUs. On the other hand, compounds with small ratios are effective at killing both the resistant and sensitive cells and require much smaUer increases in drug to kiU the resistant ceUs, as compared to the sensitive ceUs. A compound with a lower ratio, therefore, would present an advantage in cancer treatment by aUowing the more effective killing of multidrug resistant ceUs. The ratios obtained are indicated in the table below and ranged from 20 to 5xl0 δ . The compounds with lower ratios that more effectively kfll drug resistant ceUs include Compound 7, Compound 17, Compound 18, Compound 38, and Compound 6; ratios ranged from 34 to 300. As a comparison, taxol and taxotere are very ineffective at overcoming resistance, with an average ratio of 7,570. Several of the tested compounds were also more effective than taxol or taxotere in retarding growth of a multidrug resistant tumor implanted in mice. These results suggest that these new taxol analogs may be more effective in killing resistant tumor ceUs in cancer patients than taxotere and could establish a new therapeutic niche for these analogs. In using compounds of Formula I for use in angioplasty, an oral route of administration is one method of their systemic administration. Alternatively, however, these compounds may be administered by other convenient routes of administration whereby systemic activity is obtained. The patient or animal being treated must be given periodic doses of the drug in amounts effective in preventing arterial occlusion in vascular trauma associated with coronary by-pass grafts, vascular surgery, restenosis foUowing successful percutaneous transluminal coronary angioplasty (PTCA) or organ transplantation. Such effective dosages are readfly determined by methods known in the art. Dosages may be administered oraUy, parenteraUy, or by local administration to the site of vascular injury by a catheter. DaUy dosing of drug (0.01-200 mg/kg) may be administered initiaUy with higher succeeding doses as tolerated. While the preferred dosage regimen is with single daUy dosing in patients either by the oral or parenteral route, smaUer locaUy acting doses either by the oral or parenteral route, smaUer locally acting doses (1 ng/kg-1 mg/kg) may be administered at the time of the vascular intervention via local catheter instaUation or infusion in proper formulation. WhUe the preferred dosage regimen is with single daily dosing of patients, also preferred for obtining more uniform serum levels of drug are multiple dosages per day (e.g., up to 4-6 times dafly). Accordingly, when 4 daUy doses of drug are to be administered, each such dose may be about 50 mg kg per patient per dose, or higher depending on tolerance. Similar doses are employed in hon-human mammals, e.g. 0.01-200 mg/kg/day. TABLEI TABLE II Table HI. Ability of compounds to kill KB-V-1 multidrug resistant cells and KB-3-1 drug sensitive cells CHART 1 ••• Ul Where R 10 is -C(O)CH 3 and R M is -C(O)C 1 -C 6 alkyl, -C(O)OC 1 -C 6 alkyl ( preferably t-butyl), -C(O)OCH 2 CX 3 where X is Halo, -C(O)OCH 2 CH 2 SiR 20 (where 1^ is Chalky!), or -Si ^ ) 3 . CHART 2 iv R 10 = Ac oxidation 111 Where R 10 is -C(O)CH 3 and R" is -CXOK Cβalkyl, -C(O)OC 1 -C 6 a__kyl (preferably t-butyl), -C(O)OCH 2 CXg where X is Halo, -C(O)OCH 2 CH 2 SiR 20 (where R^, is C j -C β aUεyl), or -S R^. CHART3 vi Deprotection VIU IX CHART 4 Selective deprotection V1U Deprotection XI ll CHART5 Selective deprotection • •• V1U Xlll CHART 6 Selective deprotection Where R 17 is -C r C 6 alkyl, -Cg-Cβycloalkyl, -(CH^-jϊhenyl where n is 1-6, - C(O)C 1 -C 10 alkyl, -C(O)phenyl, -C(O)phenyl substituted with one, 2 or 3 C : -C 4 alkyl, Ci-C j alkoxy, halo, Ci-Cj alkylthio, trifluoromethyl, C 2 -C β dialkylamino, or nitro, - XO)naphthyl, -C(O)naphthyl substituted with one, 2 or 3 C r C 4 alkyl, C^C j alkoxy, halo, C J -C 3 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -C(O)Ophenyl, -C(O)Ophenyl substituted with one, 2 or 3 C^C^ alkyl, Cj-Cg alkoxy, halo, CHART 6 (cont.) C r C 3 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -C(O)Onaphthyl, -C(O)Onaphthyl substituted with one, 2 or 3 Ci-Q alkyl, Ci-Ca alkoxy, halo, alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -C(O)OC 1 -C 10 alkyl, -C(O)NHC 1 -C 10 alkyl, -C(O)NHphenyl, -C(O)NHphenyl substituted with one, 2 or 3 alkoxy, halo, C j -Cg alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -C(O)NHnaphthyl, -O-C(O)NHnaphthyl substituted with one, 2 or 3 Cj-C 4 alkyl, C r C 3 alkoxy, halo, Cj-Cg alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -C(O))CH 2 CHCHCl 2 , -C(O)OCH 2 CCl 3 , -SiR 16 [where R 16 is Cj-Cgalkyl or cyclo (C 6 -C 8 ) alkyl, with the proviso that at least two where n is 1-3, -CH 2 -O-(CH 2 ) n phenyl substituted with one, 2 or 3 C j -Q, alkyl, alkoxy, halo, alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro and where n is 1-3, -CH 2 -O-CH 2 -CX q H 3 ^ where q = 0-3 and X is halogen. CHART7 XVI xvu XIX CHART8 4a,b CHART9 CHART10 ex 6 CHART11 CHART12 12 CHART13 ex 12 14 15 CHART14 14 ex 13 17 CHART15 18 CHART16 19 20 21 22 4a,b CHART17 18 CHART 18 Ph O J ex 21 OMe H,N OH 25 SUBSTITUTE SWEET (RULE 26) CHART19 30a 32a R = TES 32b R = H CHART20 CHART21 36 CHART22 37 38 CHART23 38 SUBSTITUTE SHEET (RULE £§) CHART24 41 CHART25 43 CHART26 20 44 45 CHART27 46 47 41 CHART28 32b 48 49 43 CHART29 50a,b 52 52 53 54 CHART31 54 55 56 55 57 58 17 CHART33 57 59 CHART34 54 56 CHART 35 56 60 61 18 SUBSTITUTE SHEET {RULE 26) CHART36 60 62 38 CHART37 53 63 64 65 CHART38 67 CHART39 53 68 69 70 CHART40 43 CHART41 72 73 CHART42 64 CHART43 69 CHART44 53 76 77 CHART45 72 CHART 46 80a: TLC Silica gel; 50% ethyl acetate:heptane, rf = .44 80b: TLC Silica gel; 50% ethyl acetate:heptane, rf = .44 81a: TLC Silica gel; 50% ethyl acetate:heptane, rf = .55 a = R".R 41 -Me t R 42 =2-(3-methylbutyl) b = R 40 =R 41 =Me, R 2 =cyclohexyl CHART47 79 82 83 84 CHART48 84 50a,b 87 CHART49 87 54 CHART50 87 89 CHART51 CHART52 87 91 CHART53 SUBSTTTUTE SHEET (RULE 26) CHART54 92 93 94 CHART55 94 95 85 CHART56 96 97 98 CHART57 98 50a,b CHART 58 100 101 102 SUBSTTTUTE SHEET (RULE 26) CHART 59 102 50a,b SUBSTTTUTE SHEET (RULE 26) CHART60 105 106 SUBSTITUTE SHEET (RULE 2tt CHART61 72 CHART62 100 101 CHART63 109 110 50a,b CHART64 113 114 CHART65 73 CHART66 99 CHART67 103 111 CHART68 PartB Taxol

Claims: CLAIMS 1. A compound of the Formula I: wherein: X 2 is selected from the group consisting of -H, -C r C 4 alkyl, -Ci-Cg alkoxy, halo, -C r Cg alkylthio, -trifluoromethyl, -C 2 -C 6 dialkylamino, benzyloxymethyl, cyano, azide (N 3 ), or nitro; R x is selected from the group consisting of -CH 3 , -C β H 6 or phenyl substituted with one, 2 or 3 C 1 -C 4 alkyl, C^C g alkoxy, halo, C j -Cg alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro,-2-furyl, 2-thienyl, 1-naphthyl, 2-naphthyl or 3,4-methylenedioxyphenyl; a is selected from the group consisting of -H, -NHCCO^-NHCCO Cualkyl, -NHC(O)phenyl, -NHC(O)phenyl substituted with one, 2 or 3 C r C 4 alkyl, alkoxy, halo, alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, -NHC(O)C(CH 3 )=CHCHg, -NHC(O)OC(CH 3 ) 3 , -NHC(O)OCH 2 phenyl, -NH 2 , -NHSO 2 -4-methylphenyl, -NHC(O)(CH 2 ) 3 COOH, -NHC(O)-4-(SO 3 H)phenyl, -OH, -NHC(O)-l-adamantyl, -NHC(O)O-3-tetrahydrofuranyl, -NHC(O)O-4-tetrahydropyranyl, -NHC(O)CH 2 C(CH 3 ) 3 , -NHC(O)C(CH 3 ) 3 , -NHCCOOCi-Cioalkyl, -NHCCOJNHCi-Cioalkyl, -NHC(O)NHPh, -NHC(O)NHPh substituted with one, 2 or 3 alkoxy, halo, alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -NHC(O)C 3 -C 8 cycloalkyl, -NHC(O)OC(CH 2 CHg) 2 CH 8 , -NHC(O)OC(CH 3 ) 2 CH 2 Cl, -NHC(O)OC(CH 3 ) 2 CH 2 CH 3 , phthalimido, -NHC(O)-l-phenyl-l-cyclopentyl, -NHC(O)-l-methyl-l-cyclohexyl, -NHC(S)NHC(CH 3 )g or -NHC(O)NHCC(CH 3 ) 3 ; R 3 is selected from the group consisting of -H, -NHC(O)phenyl or -NHC(O)OC(CH 3 ) 3 , with the overall proviso that one of R« > and R 3 is -H but B^ and R 3 are not both -H; R 4 is -H or selected from the group consisting of -OH, -OAc (-OC(O)CH 3 ), -OC(O)OCH 2 C(Cl) 3 , -OCOCH 2 CH 2 NH 3 + HCOO " , -NHC(O)phenyl, -NHC(O)OC(CH 3 ) 3 , -OCOCH 2 CH 2 COOH and pharmaceutically acceptable salts thereof, -OCO(CH 2 ) 3 COOH and pharmaceutically acceptable salts thereof, and -OC(O)-Z-C(O)-R' [where Z is ethylene (-CH 2 CH 2 -), propylene (-CH 2 CH 2 CH 2 -), -CH=CH-, 1,2-cyclohexane or 1,2- phenylene, R' is -OH, -OH base, -NR'a 'g, -OR' 3 , -SR' 3 , -OCH 2 C(O)NR' 4 R' B where R' 2 is - H or -CH 3 , R' 3 is -(CH 2 ) n NR' 6 R' 7 or (CH 2 ) n N + R' 6 R' 7 R' 8 X " where n is 1-3, R' 4 is -H or -C r C 4 alkyl, R' B is -H, -C 1 -C 4 alkyl, benzyl, hydroxyethyl, -CH 2 CO 2 H or dimethylaminoethyl, R' 6 and R' 7 are -CH 3 , -CH 2 CH 3 , benzyl or R' 6 and R' 7 together with the nitrogen of NR' 6 R' 7 form a pyrrolidino, piperidino, morpholino, or N-methylpiperizino group; R'„ is - CH 3 , -CH 2 CH 3 or benzyl , X " is halide, and base is NH 3 , N(CH 3 ) 3 , CH 3 N(C 2 H 4 ) 2 NH, NH 2 (CH 2 ) 6 NH 2 , N-methylglucamine, NaOH or KOH], - OC(O)(CH 2 ) n NR 2 R 3 [where n is 1-3, R 2 is -H or -Ci-Cgalkyl and R 3 -H or -C 1 -C 8 alkyl], -OC(O)CH(R")NH 2 [where R" is selected from the group consisting of -H, -CH 3 , -CH 2 CH(CH 3 ) 2 , -CH(CH 3 )CH 2 CH 3 , -CH(CH 3 ) 2 , -CH 2 phenyl, -(CH 2 ) 4 NH 2 , -CH 2 CH 2 COOH, -(CH 2 ) 3 NHC(=NH)NH 2 ], the residue of the amino acid proline, -OC(O)CH=CH 2 , -C(O)CH 2 CH 2 C(O)NHCH 2 CH 2 SO 3 . Y + , -OC(O)CH 2 CH 2 C(O)NHCH 2 CH 2 CH 2 SO 3 Υ + wherein Y + is Na + or N + (Bu) 4 , -OC(O)CH 2 CH 2 C(O)OCH 2 CH 2 OH; R 6 is -H or -OH, with the overall proviso that when R 6 is -OH, R 4 is -H and with the further proviso that when R 5 is -H, R 4 is other than -H; R 6 is -H:-H when , is α-R 71 :β-R 7 where one of R^ and R 72 is -H and the other of R γj and R^ is -X^ where , is halo or azido (-N 3 ) and R 8 is -CH 3 ; R 6 is -H:-H when , is α-H.β-R^ where R 74 and R 8 are taken together to form a cyclopropyl ring; R 6 is eg-Ree when R, is R 6 :R 76 where one of Rgg and R^ is taken together with one of R j g and H, 6 to form a second bond between the carbon atoms to which they are attached and the other of R^ and R^ is -H, and the other of R^ and R^ is -H and where R 8 is -CH 3 ; R 6 is -H:-H when , is α-R 81 :β-R 82 where one of R 81 and R 82 is -H and the other of R 81 and R 82 is -OH or -H and R 8 is -CH 3 ; R 6 is -H:-H when R, is α-R 91 :β-R 92 where one of Rg and Rg 2 is -H and the other of g and Rg 2 is -W where W is selected from the group consisting of -O-Ci-Cgalkyl, -O-C 3 -C 6 cycloalkyl, -O-(CH 2 ) n phenyl where n is 1-6, -O-C(O)C 1 -C 10 alkyl, -O-C(O)phenyl, - O-C(O)phenyl substituted with one, 2 or 3 C 1 -C 4 alkyl, Cj-Cg alkoxy, halo, Ci-Cg alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -O-C(O)naphthyl, -O-C(O)naphthyl substituted with one, 2 or 3 C^^ alkyl, C r C 3 alkoxy, halo, C j -Cg alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -O-C(O)Ophenyl, -O-C(O)Ophenyl substituted with one, 2 or 3 alkoxy, halo, C j -Cg alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -O-C(O)Onaphthyl, -O-C(O)Onaphthyl substituted with one, 2 or 3 alkyl, Cx-Cg alkoxy, halo, Ci-Ca alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -O-CCOOC j -Cu j alkyl, -O-C(O)NHC r C 10 alkyl, -O-C(O)NHphenyl, -O-C(O)NHphenyl substituted with one, 2 or 3 C r C 4 alkyl, alkoxy, halo, C x -C 3 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -O-C(O)NHnaphthyl, -O-C(O)NHnaphthyl substituted with one, 2 or 3 C r C 4 alkyl, C j -Cg alkoxy, halo, Cj-Cg alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, - O-C(O)OCH 2 CHCl 2 , -O-C(O)OCH 2 CCl 3 , -Si(R 16 ) 3 [where R 16 is C^ealk l or cyclo (C 5 -C 8 ) alkyl, with the proviso that at least two R 16 moieties are C j -Cealkyl], -O-C z-O-C^ C 6 alkyl, -O-CH^O-CCH^j-henyl where n is 1-3, -O-CH^O-CCH^jώenyl substituted with one, 2 or 3 alkoxy, halo, alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro and where n is 1-3, where q = 0-3 and X is halogen, and R 8 is -CH 3 ; Rg 0 is -H, -OH, or -OC(O)CH 3 ; and pharmaceutically acceptable salts thereof when the compound contains either an acidic or basic functional group. 2. A compound according to Claim 1 wherein ^ is -NHC(O)C 6 H 5 , R 4 is hydroxy, R 3 and R s are -H, and R x is phenyl or substituted phenyl. 3. A compound according to Claim 1 wherein Ra is -NHC(O)OC(CH 3 ) 3 , R x is phenyl or substituted phenyl, R 4 is hydroxy, and R 3 and R 5 are -H. 4. A compound according to Claim 1 wherein Rg is where one of Rgg and R^ is taken together with one of R^ and R^ to form a second bond between the carbon atoms to which they are attached and the other of R 65 and R 66 is -H, and the other of R^ and R^ is -H and where R 8 is -CH 3 . 5. A compound according to Claim 4 namely, 7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol and 10- acetyl-7-deo^-Δ 6,7 -Δ 12 ' 13 -iso-taxotere. 6. A compound according to Claim 1 wherein R 6 is -H:-H when R, is α- ^-β- where one of R^ and R^ is -H and the other of R^ and ^ is -X 7 where Xγ is halo or azido (-N 3 ) and R 8 is -CH 3 . 7. A compound according to Claim 6 selected from the group consisting of 7-deoxy-7α-fluoro-Δ 1 ,13 -iso-taxol and 7-deoxy-7β-fluoro-Δ 12 ' 13 -iso-taxol and 10-acetyl-7- deoxy-7α-fluoro-Δ 12 ' 13 -iso-taxotere, and 10-acetyl-7-deoxy-7β-fluoro-Δ 12 ' 13 -iso-taxotere. 8. A compound according to Claim 1 wherein Rg is -H:-H when R 7 is α-H.β-R^ where R 74 and R 8 are taken together to form a cyclopropyl group. 9. A compound according to Claim 8 namely, 7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol and 10-acetyl-7-deoxy-7β,8β-methano-Δ 1 ' 13 -iso-taxotere. 10. A compound according to Claim 1 wherein R 6 is -H:-H when , is α-R 81 :β-R 82 where one of R 81 and R 82 is -H or and the other of R 81 and R 82 is -OH and R 8 is -CH 3 . 11. A compound according to Claim 1 wherein R 6 is -H:-H when R, is α-R g ^β-R g a where one of R^ and Rg 2 is -H and the other of R^ and Rg 2 is -W where W is selected from the group consisting of -O-Ci-Cgalkyl, -O-C 3 -C 6 cycloalkyl, -O-CCHa^henyl where n is 1-6, -O-C(O)C r C 10 alkyl, -O-C(O)phenyl, -O-C(O)phenyl substituted with one, 2 or 3 alkoxy, halo, alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -O-C(O)naphthyl, -O-C(O)naphthyl substituted with one, 2 or 3 C^^ alkyl, alkoxy, halo, C j -C,, alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -O-C(O)Ophenyl, -O-C(O)Ophenyl substituted with one, 2 or 3 C r C 4 alkyl, C^C g alkoxy, halo, C j -Cg alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -O-C(O)Onaphthyl, - O-C(O)Onaphthyl substituted with one, 2 or 3 C^ alkyl, C j -C 3 alkoxy, halo, C j -Cg alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -O-CCOJOCi-Cualkyl, -O-C(O)NHC 1 -C 10 alkyl, -O-C(O)NHphenyl, -O-C(O)NHphenyl substituted with one, 2 or 3 alkoxy, halo, alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -O-C(O)NHnaphthyl, -O-C(O)NHnaphthyl substituted with one, 2 or 3 alkoxy, halo, C j -C 8 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -O-C(O)OCH 2 CHCL,, -O-C(O)OCH 2 CCl 3 , -Si(R 16 ) 3 [where R 16 is -O-CHa-O-Ci-Cgalkyl, -O-CH 2 -O-(CH 2 ) n phenyl where n is 1-3, -O-CH 2 -O-(CH 2 ) n phenyl substituted with one, 2 or 3 C r C 4 alkyl, Cj-Cg alkoxy, halo, alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro and where n is 1-3, -O-CHa-O-CHa-CX q H^ where q = 0-3 and X is halogen and R 8 is -CH 3 . 12. A compound according to Claim 11 where W is selected from the group consisting of propionyl; O-(2,2-dichloroethyl)carbonate; O-(2-chloroethyl)carbonate; O-methyl; O-propyl; O-allyl; O-methoxymethyl; O-ethoxymethyl; O-methoxyethoxymethyl; O-benzyloxymethyl; O-(2,2,2-trichloroethoxy)methyl; and O-(2,2,2-trichloroethoxy)methoxymethyl. 13. A compound according to Claim 1 selected from the group consisting of 7-deoxy-Δ 6 ' 7 -Δ 12 ' 13 -iso-taxol; 10-acetyl-7-deoxy-Δ 6,7 -Δ 12 ' 13 -iso-taxotere; 2'-succinyl-7-deoxy-Δ 6,7 -Δ 12 ' 13 -iso-taxol; 2'-(β-alanyl)-7-deoxy-Δ 6 ' 7 -Δ 12 ' 13 -iso-taxol formate; 2'-glutaryl-7-deoxy-Δ 6 ' 7 -Δ 12 - 13 -iso-taxol; 2'-[-C(O)(CH 2 ) 3 C(O)NH(CH 2 ) 3 N(CH 3 ) 2 ]-7-deoxy-Δ 6 - 7 -Δ 12 ' 13 -iso-taxol; 2'-(β-sulfopropionyl)-7-deoxy-Δ 6,7 -Δ 12 ' 13 -iso-taxol; 2'-(2-sulfoethylamido)succinyl-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 2'-(3-sulfopropylamido)succinyl-7-deoxy-Δ 6,7 -Δ 12 ' 13 -iso-taxol; 2'-(triethylsilyl)-7-deoxy-Δ 6 - 7 -Δ 12 ' 13 -iso-taxol; 2 , -(t-butyldimethylsilyl)-7-deoxy-Δ 6 - 7 -Δ 1 ' 13 -iso-taxol; 2'-(N,N-diethylaminopropionyl)-7-deoxy-Δ 6,7 -Δ 12 ' 13 -iso-taxol; 2'-(N,N-dimethylglycyl)-7-deoxy-Δ 6 - 7 -Δ 12 ' 13 -iso-taxol; 2'-(glycyl)-7-deoxy-Δ 6 ' 7 -Δ 12 ' 13 -iso-taxol; 2'-(L-alanyl)-7-deoxy-Δ 6 ' 7 -Δ 12 ' 13 -iso-taxol; 2'-(L-leucyl)-7-deoxy-Δ 6 ' 7 -Δ 12 - 13 -iso-taxol; 2'-(L-isoleucyl)-7-deoxy-Δ 6 ' 7 -Δ 12,13 -iso-taxol; 2'-(L-valyl)-7-deoxy-Δ 6 ' 7 -Δ 12 ' 13 -iso-taxol; 2'-(L-phenylalanyl)-7-deoxy-Δ 6 ' 7 -Δ 12 ' 13 -iso-taxol; 2'-(L-prolyl)-7-deoxy-Δ 6 ' 7 -Δ 12 13 -iso-taxol; 2'-(L-lysyl)-7-deoxy-Δ 6 - 7 -Δ 1 ' 13 -iso-taxol; 2'-(L-glutamyl)-7-deoxy-Δ 6 - 7 -Δ 12,13 -iso-taxol; 2'-(L-arginyl)-7-deoxy-Δ 6,7 -Δ 12 ' 13 -iso-taxol; 7-deoxy-Δ 6l7 -Δ 12 ' 13 -iso-taxotere; 7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-succinyl-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(β-alanyl)-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol formate; 2'-glutaryl-7-deoxy-7-fluoro-Δ 1 ' 13 -iso-taxol; 2'-[-C(O)(CH 2 ) 3 C(O)NH(CH 2 ) 3 N(CHg) 2 ]-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(β-sulfopropionyl)-7-deoxy-7-fluoro-Δ 12 X3 -iso-taxol; 2'-(2-sulfoethylamido)succinyl-7-deoxy-7-fluoro-Δ 1213 -iso-taxol; 2'-(3-sulfopropylamido)succinyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(triethylsilyl)-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(t-bulyldimethylsilyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(N,N-diethylaminopropionyl)-7-deoxy-7-fluoro-Δ 12 :l3 -iso-taxol; 2'-(N,N-dimethylglycyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(glycyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(L-alanyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(L-leucyl)-7-deoxy-7-fluoro-Δ 1213 -iso-taxol; 2'-(L-isoleucyl)-7-deoxy-7-fluoro-Δ 12,:l3 -iso-taxol; 2'-(L-valyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 2'-(L-phenylalanyl)-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(L-prolyl)-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(L-lysyl)-7-deoxy-7-fluoro-Δ 1 ,13 -iso-taxol; 2'-(L-glutamyl)-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(L-arginyl)-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-tetrahydropyran-4-yloxycarbonyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-pivaloyl-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-/ι-hexylaminocarbonyl-7-deoxy-7-fluoro-Δ 1 13 -iso-taxol; 7-deoxy-7α-fluoro-Δ 1213 -iso-taxol; 7-deoxy-7β-fluoro-Δ 1213 -iso-taxol; 2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-7α-fluoro-Δ 12 ' 13 -iso-taxol; 2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-7β-fluoro-Δ 12 13 -iso-taxol; 2'-succinyl-7-deoxy-7α-fluoro-Δ 12,13 -iso-taxol; 2'-(β-alanyl)-7-deoxy-7α-fluoro-Δ 12,13 -iso-taxol formate; 2'-glutaryl-7-deoxy-7α-fluoro-Δ 1213 -iso-taxol; 2'-[-C(O)(CH 2 )gC(O)NH(CH 2 ) 3 N(CH 3 ) 2 ]-7-deoxy-7α-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(β-sulfopropionyl)-7-deoxy-7α-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(2-sulfoethylamido)succinyl-7-deoxy-7α-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(3-sulfopropylamido)succinyl-7-deoxy-7α-fluoro-Δ 12,13 -iso-taxol; 2'-(triethylsilyl)-7-deoxy-7α-fluoro-Δ 1 ,13 -iso-taxol; 2'-(t-butyldimethylsilyl)-7-deoxy-7α-fluoro-Δ 1 ,13 -iso-taxol; 2'-(N,N-diethylaminopropionyl)-7-deoxy-7α-fluoro-Δ 1 13 -iso-taxol; 2'-(N,N-dimethylglycyl)-7-deoxy-7α-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(glycyl)-7-deo3ςy-7α-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(L-alanyl)-7-deoxy-7α-fluoro-Δ 12,13 -iso-taxol; 2'-(L-leucyl)-7-deo3ζy-7α-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(L-isoleucyl)-7-deoxy-7α-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(L-valyl)-7-deoxy-7α-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(L-phenylalanyl)-7-deoxy-7α-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(L-prolyl)-7-deoxy-7α-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(L-lysyl)-7-deoxy-7α-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(L-glutamyl)-7-deoxy-7α-fluoro-Δ 1 ' 13 -iso-taxol; 2'-(L-arginyl)-7-deoxy-7α-fluoro-Δ 12 ' 13 -iso-taxol; 2'-succinyl-7-deoxy-7β-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(β-alanyl)-7-deoxy-7β-fluoro-Δ 12 ' 13 -iso-taxol formate; 2'-glutaryl-7-deoxy-7β-fluoro-Δ 12,13 -iso-taxol; 2'-[-C(O)(CH 2 ) 3 C(O)NH(CH 2 ) 3 N(CH 3 ) 2 ]-7-deoxy-7β-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(β-sulfopropionyl)-7-deoxy-7β-fluoro-Δ 12 ' 13 -iso-taxol; 2 , -(2-sulfoethylamido)succinyl-7-deoxy-7β-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(3-sulfopropylamido)succinyl-7-deoxy-7β-fluoro-Δ 12 13 -iso-taxol; 2'-(triethylsilyl)-7-deoxy-7β-fluoro-Δ 12 13 -iso-taxol; 2'-(t-butyldimethylsilyl)-7-deoxy-7β-fluoro-Δ 12,13 -iso-taxol; 2'-(N,N-diethylaminopropionyl)-7-deoxy-7β-fluoro-Δ 1213 -iso-taxol; 2'-(N,N-dimethylglycyl)-7-deoxy-7β-fluoro-Δ 1213 -iso-taxol; 2'-(glycyl)-7-deoxy-7β-fluoro-Δ 12,13 -iso-taxol; 2'-(L-alanyl)-7-deoxy-7β-fluoro-Δ 12 - 13 -iso-taxol; 2'-(L-leucyl)-7-deoxy-7β-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(L-isoleucyl)-7-deoxy-7β-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(L-valyl)-7-deoxy-7β-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(L-phenylalanyl)-7-deo3cy-7β-fluoro-Δ 12,13 -iso-taxol; 2'-(L-prolyl)-7-deoxy-7β-fluoro-Δ 12 ' 13 -iso-taxol; 2'-(L-lysyl)-7-deoxy-7β-fluoro-Δ 12 ' :l3 -iso-taxol; 2'-(L-glutamyl)-7-deoxy-7β-fluoro-Δ 1213 -iso-taxol; 2'-(L-arginyl)-7-deoxy-7β-methano-Δ 12 13 -iso-taxol; 7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2'-[{(2,2,2-trichloroethyl)oxy}carbonyl]-7-deoxy-7β,8β-methano-Δ 1 ,13 -iso-taxol; 2'-succinyl-7-deoxy-7β,8β-methano-Δ 1213 -iso-taxol; 2'-(β-alanyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol formate; 2'-glutaryl-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2'-[-C(O)(CH 2 ) 3 C(O)NH(CH 2 ) 3 N(CH 3 ) 2 ]-7-deoxy-7β,8β-methano-Δ 12 - 13 -iso-taxol; 2'-(β-sulfopropionyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; 2'-(2-sulfoethylamido)succinyl-7-deoxy-7β,8β-methano-Δ 121 -iso-taxol; 2'-(3-sulfopropylamido)succinyl-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2'-(triethylsilyl)-7-deoxy-7β,8β-methano-Δ 1213 -iso-taxol; 2'-(t-bu yldimethylsilyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2'-(N,N-diethylaminopropionyl)-7-deoxy-7β,8β-methano-Δ 12*13 -iso-taxol; 2'-(N,N-dimethylglycyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; 2'-(glycyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; 2'-(L-alanyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; 2'-(L-leucyl)-7-deoxy-7β,8β-methano-Δ 12 13 -iso-taxol; 2'-(L-isoleucyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 2'-(L-valyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; 2'-(L-phenylalanyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; 2'-(L-prolyl)-7-deoxy-7β,8β-methano-Δ 12 ' ls -iso-taxol; 2'-(L-lysyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; 2'-(L-glutamyl)-7-deθ3ςy-7β,8β-methano-Δ 12,13 -iso-taxol; 2'-(L-arginyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxotere; N-debenzoyl-N-tetrahydrofuran-3-ylo^carbonyl-7-deoxy-7β,8β-methano-Δ 12,13 -iso- taxol; N-debenzoyl-N-(l-adamantoyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol or N-debenzoyl-N-phenylaminocarbonyl-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol. 14. A pharmaceutical composition comprising an effective antitumor amount of at least one compound of the Formula I: wherein: X 2 is selected from the group consisting of -H, -C : -C 4 alkyl, -Ci-Cg alkoxy, halo, -C r C 3 alkylthio, -trifluoromethyl, -C 2 -C 6 dialkylamino, benzyloxymethyl, cyano, azide (N 3 ), or nitro; R x is selected from the group consisting of -CH 3 , -C 6 H 5 or phenyl substituted with one, 2 or 3 alkyl, alkoxy, halo, Cj-Cg alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, 2-furyl, 2-thienyl, 1-naphthyl, 2-naphthyl or 3,4-methylenedioxyphenyl; R 2 is selected from the group consisting of -H, -NHC^H.-NHCCO^-C j oalkyl, -NHC(O)phenyl, -NHC(O)phenyl substituted with one, 2 or 3 C r C 4 alkyl, C r C g alkoxy, halo, C -C 3 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, -NHC(O)C(CH 3 )=CHCHg, -NHC(O)OC(CH 3 ) 3 , -NHC(O)OCH 2 phenyl, -NH 2 , -NHSO 2 -4-methylphenyl, -NHC(O)(CH 2 ) 3 COOH, -NHC(O)-4-(SO 3 H)phenyl, -OH, -NHC(O)-l-adamantyl, -NHC(O)O-3-tetrahydrofuranyl, -NHC(O)O-4-tetrahydropyranyl, -NHC(O)CH 2 C(CH 3 )g, -NHC(O)C(CH 3 ) 3 , -NHC(O)OC r C 10 alkyl, -NHC(O)NHC 1 -C 10 alkyl, - NHC(O)NHPh, -NHC(O)NHPh substituted with one, 2 or 3 CyC^ alkyl, C j -Cg alkoxy, halo, C j -Cg alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -NHC(O)C 3 -C 8 cycloalkyl, -NHC(O)OC(CH 2 CH 3 ) 2 CH 3 , -NHC(O)OC(CH 3 ) 2 CH 2 Cl, -NHC(O)OC(CH 3 ) 2 CH 2 CH 3 , phthalimido, -NHC(O)-l-phenyl-l-cyclopentyl, -NHC(O)-l-methyl-l-cyclohexyl, -NHC(S)NHC(CH 3 ) 3 or -NHC(O)NHCC(CH 3 ) 3 ; R g is selected from the group consisting of -H, -NHC(O)phenyl or -NHC(O)OC(CH 3 ) 3 , with the overall proviso that one of R j and R 3 is -H but ^ and R 3 are not both -H; R 4 is -H or selected from the group consisting of -OH, -OAc (-OC(O)CH 3 ), -OC(O)OCH 2 C(Cl) 3 , -OCOCH 2 CH 2 NH 3 + HCOO ' , -NHC(O)phenyl, -NHC(O)OC(CH 3 ) 3 , -OCOCH 2 CH 2 COOH and pharmaceutically acceptable salts thereof, -OCO(CH 2 ) 3 COOH and pharmaceutically acceptable salts thereof, and -OC(O)-Z-C(O)-R' [where Z is ethylene (-CH 2 CH 2 -), propylene (-CH 2 CH 2 CH 2 -), -CH=CH-, 1,2-cyclohexane or 1,2- phenylene, R' is -OH, -OH base, -NR'-jR',,, -OR' 3 , -SR' 3 , -OCH 2 C(O)NR' 4 R' 6 where R' 2 is -H or -CH 3 , R' 3 is -(CH 2 ) n NR' 6 R' 7 or (CH 2 ) n N + R' 6 R' 7 R' 8 X " where n is 1-3, R' 4 is -H or -C 1 -C 4 alkyl, R' 5 is -H, benzyl, hydroxyethyl, -CH 2 CO 2 H or dimethylaminoethyl, R' 6 and R' 7 are -CH 3 , -CH 2 CH 3 , benzyl or R' 6 and R' 7 together with the nitrogen of NR' 6 R' 7 form a pyrrolidino, piperidino, morpholino, or N-methylpiperizino group; R' 8 is -CH 3 , -CH 2 CH 3 or benzyl , X " is halide, and base is NH 3 , (HOC 2 H 4 ) 3 N, N(CH 3 ) 3 , CH 3 N(C 2 H 4 ) 2 NH, NH 2 (CH 2 ) 6 NH 2 , N-methylglucamine, NaOH or KOH], -OC(O)(CH 2 ) n NR 2 R 3 [where n is 1-3, R 2 is -H or -Cj-Cgalkyl and R 3 -H or -Ci-C 8 alkyl], -OC(O)CH(R")NH 2 [where R" is selected from the group consisting of -H, -CH 3 , -CH 2 CH(CH 3 ) 2 , -CH(CH 3 )CH 2 CH 3 , -CH(CH 3 ) 2 , -CH 2 phenyl, -(CH 2 ) 4 NH 2 , -CH 2 CH 2 COOH, -(CH 2 ) 3 NHC(=NH)NH 2 ], the residue of the amino acid proline, -OC(O)CH=CH 2 , -C(O)CH 2 CH 2 C(O)NHCH 2 CH 2 SO 3 . Y + , -OC(O)CH 2 CH 2 C(O)NHCH 2 CH 2 CH 2 SO 3 Υ + wherein Y + is Na* or N + (Bu) 4 , -OC(O)CH 2 CH 2 C(O)OCH 2 CH 2 OH; R 6 is -H or -OH, with the overall proviso that when R 6 is -OH, R 4 is -H and with the further proviso that when R 5n is -H, R 4 is other than -H; Rg is -H:-H when R, is α-R 71 :β-R 72 where one of ^ and R 72 is -H and the other of R^ and R, 2 is -X, where X, is halo or azido (-N 3 ) and R 8 is -CH 3 ; R 6 is -H:-H when R, is α-H:β- 74 where K, 4 and R 8 are taken together to form a cyclopropyl ring; R 6 is RggiR when R, is R 76 :R 76 where one of Rgg and Rgg is taken together with one of ΕL jB and R^ to form a second bond between the carbon atoms to which they are attached and the other of R^ and Rgg is -H, and the other of ^ and R^ is -H and where R 8 is -CH 3 ; R 6 is -H:-H when H, is α-R 81 :β-R 82 where one of R 81 and R 82 is -H and the other of R 81 and R 82 is -OH or -H and R 8 is -CH 3 ; R 6 is -H:-H when R, is α-R 91 :β-R 92 where one of Rg X and Rg 2 is -H and the other of Rg j and Rg 2 is -W where W is selected from the group consisting of -O-Ci-Cgalkyl, -O-C jj -C 8 cycloalkyl, -O-(CH 2 )j>henyl where n is 1-6, -O-C(O)C 1 -C 10 alkyl, -O-C(O)phenyl, - O-C(O)phenyl substituted with one, 2 or 3 alkoxy, halo, C -C 3 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -O-C(O)naphthyl, -O-C(O)naphthyl substituted with one, 2 or 3 C 1 -C 4 alkyl, C r C 3 alkoxy, halo, C j -C 8 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -O-C(O)Ophenyl, -O-C(O)Ophenyl substituted with one, 2 or 3 C^C^ alkyl, Cj-Cg alkoxy, halo, C j -C 8 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -O-C(O)Onaphthyl, -O-C(O)Onaphthyl substituted with one, 2 or 3 C 1 -C 4 alkyl, alkoxy, halo, Ci-C 8 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -O-CCOJOC^C alkyl, -O-CCOJNHC 1 -Cioalkyl, -O-C(O)NHphenyl, -O-C(O)NHphenyl substituted with one, 2 or 3 C 1 -0 4 alkyl, alkoxy, halo, alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, -O-C(O)NHnaphthyl, -O-C(O)NHnaphthyl substituted with one, 2 or 3 C r C 4 alkyl, C x -C 3 alkoxy, halo, alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, - O-C(O)OCH 2 CHCl 2 , -O-C(O)OCH 2 CCl 3 , -Si(R 16 ) 3 [where R 16 is C r C 6 alkyl or cyclo (C ε -C 8 ) alkyl, with the proviso that at least two R 16 moieties are C α -C 6 alkyl], -O-CHg-O-Ci-Cgalkyl, -O-CH 2 -O-(CH 2 ) n phenyl where n is 1-3, -O-CHa-O-CCHa^henyl substituted with one, 2 or 3 C r C 4 alkyl, C^Q, alkoxy, halo, C r C 3 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro and where n is 1-3, 0-3 and X is halogen, and R 8 is -CH 3 ; Rg 0 is -H, -OH, or -OC(O)CH 3 ; and pharmaceutically acceptable salts thereof when the compound contains either an acidic or basic functional group. 15. A compound according to Claim 1 selected from the group consisting of 10-acetyl-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxotere; 10-acetyl-7β,8β-methano-Δ X2,13 -iso-taxotere; 10-acetyl-7-deoxy-Δ 6,7 -Δ 12 ' 13 -iso-taxotere; 13-(N-Boc-β-phenyl isoserinyl)-Δ 1 13 -iso-baccatin III (7); 10-deacetyl-13-(N-Boc-β-phenyl isoserinyl)-Δ 1 13 -iso-baccatin III (8); 7-Troc-13-(N-Boc-β-phenyl isoserinyl)-Δ 1213 -iso-baccatin III (12); 2'-Troc-13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-baccatin III (13); 2'-Troc-13-(N-Boc-β-phenylisoserinyl)-7-deoxy-7b,8b-methano-Δ 12,13 -iso-baccatin III (14); 2'-Troc-13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-Δ 6,7 -Δ 12 ' 13 -iso-baccatin III (15); 13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-7-fluoro-Δ 1213 -iso-baccatin III (16); 13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-7b,8b-methano-Δ 12,13 -iso-baccatin III (17); 13-(N-Boc-β-phenyl isoserinyl)-7-deoxy-Δ 6,7 -Δ 1 ,:l3 -iso-baccatin III (18); 7-TES-13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyD-Δ^'^-iso-baccatin III (32a); 13-(N-(t-butylaminocarbonyl)-β-phenyl isoserinyl)-Δ 12,13 -iso-baccatin III (32b); 7-ethoxymethyl-13-(N-Boc-β-phenyl isoserinyD-Δ^ so-baccatin III (41); and 7-methoxymethyl-13-(N-Boc-β-phenyl isoserinyD-Δ^ ^-iso-baccatin III (66). 16. A compound according to Claim 1 selected from the group consisting of N-debenzoyl-N-tetrahydroftu-an-3-yloxycarbonyl-7-deoxy-7β,8β-methano-Δ 12,13 -iso- taxol; N-debenzoyl-N-(l-adamantoyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-phenylaminocarbonyl-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-t-butylaminocarbonyl-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(l-methyl-l-cyclohexylanoyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso- taxol; N-debenzoyl-N-( 1-phenyl- l-cyclopentanoyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-phthalimido-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-t-butylaminothiocarbonyl-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-t-amyloxycarbonyl-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-neopentyloxycarbonyl-7-deoxy-7β,8β-methano-Δ 1 ' 13 -iso-taxol; N-debenzoyl-N-(2-chloro- 1, l-dimethylyethyl)oxycarbonyl-7-deoxy-7β,8β-methano- Δ^-iso-taxol; N-debenzoyl-N-(3-methyl-3-pentyl)oxycarbonyl-7-deoxy-7β,8β-methano-Δ 12,13 -iso- taxol; N-debenzoyl-N-tetrahydropyran-4-yloxycarbonyl-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-pivaloyl-7-deoxy-7-fluoro-Δ 1 ' 13 -iso-taxol; N-debenzoyl-N-re-hexylaminocarbonyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-t-butylaminocarbonyl-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-(l-methyl-l-cyclohexylanoyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-(l-phenyl-l-cyclopentanoyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-phthalimido-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-t-butylaminothiocarbonyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-t-amyloxycarbonyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-neopentyloxycarbonyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-(2-chloro-l,l-dimethylyethyl)o^rcarbonyl-7-deoxy-7-fluoro-Δ 12 ' 13 - iso-taxol; N-debenzoyl-N-(3-methyl-3-pentyl)oxycarbonyl-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-t-butylaminocarbonyl-7-deoxy-Δ 6,7 -Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-(l-methyl-l-cyclohe3cylanoyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; N-debenzoyl-N-(l-phenyl-l-cyclopentanoyl)-7-deoxy-Δ 6,7 -Δ "'"-iso-taxol; N-debenzoyl-N-phthaHmido-7-deoxy-Δ 6,7 -Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-t-butylaminothiocarbonyl-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; N-debenzoyl-N-t-amyloxycarbonyl-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; N-debenzoyl-N-neopentyloxycarbonyl-7-deoxy-Δ 6,7 -Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-(2-chloro-l,l-dimethylyethyl)oxycarbonyl-7-deoxy-Δ 6,7 -Δ 12,13 -iso- taxol; or N-debenzoyl-N-(3-methyl-3-pentyl)oxycarbonyl-7-deoxy-Δ 6 ' 7 -Δ 12 - 13 -iso-taxol. 17. A compound according to Claim 1 selected from the group consisting of 3'-desphenyl-3'-(2-furyl)-7-deo3^-7β,8β-methano-Δ 1213 -iso-taxol; 3'-desphenyl-3'-(2-thienyl)-7-deo3cy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; 3'-desphenyl-3'-(l-naphthyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; 3'-desphenyl-3'-(2-naphthyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; 3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 3'-desphenyl-3'-(4-chlorophenyl)-7-deo3ςy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; 3'-desphenyl-3'-(4-bromophenyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; 3'-desphenyl-3'-(3,4-methylenedioxyphenyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 3'-desphenyl-3'-(3,4-dimethoxyphenyl)-7-deoxy-7β,8β-methano-Δ 1213 -iso-taxol; 3'-desphenyl-3'-(4-nitrophenyl)-7-deoxy-7β,8β-methano-Δ 12,13 -iso-taxol; 3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-7-deoxy-7β,8β-methano-Δ 1 ' 13 -iso-taxol; N-debenzoyl-N-(4-methoxybenzoyl)-7-deoxy-7β,8β-methano-Δ 1213 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7β,8β- methano-Δ^^-iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-7-deoxy-7β,8β-methano-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7β,8β- methano-Δ^'^-iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7β,8β- methano-Δ^^-iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7β,8β- methano-Δ^'^-iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-7β,8β- methano-Δ^-^-iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy- 7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7τdeoxy-7β,8β- methano-Δ^ so-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7β,8β- methano-Δ^'^-iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7β,8β- methano-Δ^'^-iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7β,8β- methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy- 7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy- 7β,8β-methano-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy- 7β,8β-methano-Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-(4-methoxybenzoyl)-3'-desphenyl-3M4-methoxyphenyl)-7-deoxy- 7β,8β-methano-Δ 1 ,13 -iso-taxol; 3'-desphenyl-3'-(2-furyl)-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; 3'-desphenyl-3'-(2-thienyl)-7-deo3^-7-fluoro-Δ 12 ' 13 -iso-taxol; 3'-desphenyl-3'-(l-naphthyl)-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; 3'-desphenyl-3'-(2-naphthyl)-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; 3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; 3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7-fluoro-Δ 12 ' 13 -iso-taxol; 3'-desphenyl-3'-(4-bromophenyl)-7-deoxy-7-fluoro-Δ ω,13 -iso-taxol; 3'-desphenyl-3'-(3,4-methylenedioxyphenyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 3'-desphenyl-3'-(3,4-dimethoxyphenyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 3'-desphenyl-3'-(4-nitrophenyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; 3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7-fluoro-Δ X2 13 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-methoxybenzoyl)-7-deoxy-7-fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deo3^-7-fluoro- Δ^-iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-7-deoxy-7-fluoro-Δ 12,:l3 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7- fluoro-Δ^ so-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3 , -(4-fluorophenyl)-7-deoxy-7-fluoro- Δ^-iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deo3Qr-7-fluoro- Δ 12 - 13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7- fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-7- fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-7- fluoro-Δ^ so-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-(_hlorophenyl)-7-deoxy-7-fluoro- Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7- fluoro-Δ^'^-iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7- fluoro-Δ 1213 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-7- fluoro-Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-7- fluoro-Δ^'^-iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3 , -desphenyl-3'-(4-methoxyphenyl)-7-deoxy-7- fluoro-Δ^'^-iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-7- fluoro-Δ 1213 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-7- fluoro-Δ^-^-iso-taxol; N-debenzoyl-N-(4-methθ3Qrbenzoyl)-3'-desphenyl-3'-(4-metho^ henyl)-7-deo3ςy-7- fluoro-Δ 12,13 -iso-taxol; 3'-desphenyl-3'-(2-furyl)-7-deoxy-Δ 6>7 -Δ 1213 -iso-taxol; 3'-desphenyl-3'-(2-thienyl)-7-deoxy-Δ 6,7 -Δ 1213 -iso-taxol; 3'-desphenyl-3'-(l-naphthyl)-7-deoxy-Δ 6 ' 7 -Δ 1213 -iso-taxol; 3'-desphenyl-3'-(2-naphthyl)-7-deoxy-Δ 6 - 7 -Δ 1213 -iso-taxol; 3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 3'-desphenyl-3'-(4-bromophenyl)-7-deoxy-Δ 6,7 -Δ 12 ' 13 -iso-taxol; 3'-desphenyl-3'-(3,4-methylenedioxyphenyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 3'-desphenyl-3'-(3,4-dimethoxyphenyl)-7-deoxy-Δ 6,7 -Δ 12 ' 13 -iso-taxol; 3'-desphenyl-3'-(4-nitrophenyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; 3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-7-deoxy-Δ 6,7 -Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-methoxybenzoyl)-7-deoxy-Δ 6,7 -Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-Δ 6,7 - Δ 12 - 13 -iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-7-deo^-Δ 6,7 -Δ 12 ' 13 -iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-Δ 6,7 - Δ 12 13 -iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-Δ 6,7 - Δ^-iso-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-Δ 6,7 - Δ^-iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-Δ 6,7 - Δ^-iso-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-metho^ henyl)-7-deoxy-Δ 6,7 - Δ^-iso-taxol; N-debenzoyl-N-(4-methylbenzoyl)-3'-desphenyl-3'-(4-methθ3Q henyl)-7-deoxy-Δ 6,7 - Δ^ so-taxol; N-debenzoyl-N-(4-fluorobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-Δ 6,7 - Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-Δ 6,7 - Δ^ so-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-Δ 6,7 - Δ 1213 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-chlorophenyl)-7-deoxy-Δ 6,7 - Δ 12,13 -iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-fluorophenyl)-7-deoxy-Δ 6,7 - Δ^-iso-taxol; N-debenzoyl-N-(4-chlorobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-Δ 6,7 - Δ^ so-taxol; N-debenzoyl-N-(4-bromobenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deo3^-Δ 6,7 - Δ^'^-iso-taxol; N-debenzoyl-N-(4-t-butylbenzoyl)-3'-desphenyl-3'-(4-methoxyphenyl)-7-deoxy-Δ 6,7 - Δ^'^-iso-taxol; and N-debenzoyl-N-(4-methoxybenzoyl)-3'-desphenyl-3M4-methoxyphenyl)-7-deoxy- Δ 6.7. Δ 12. 1 3. iso . taχoL 18. A compound of the formula wherein X 2 is selected from the group consisting of -H, -C x -C 4 alkyl, -Ci-Cg alkoxy, halo, -Ci-Cg alkylthio, -trifluoromethyl, -C 2 -C 6 dialkylamino, benzyloxymethyl, cyano, azide (N 3 ), or nitro; and wherein Rg 0 and R^, being the same or different, are selected from the group consisting of -OC(O)C 1 -C 6 alkyl, -OC(O)OC 1 -C 6 alkyl, -OC(O)OCH 2 CX 3 where X is Halo, -OC(O)OCH 2 CH 2 SiR 20 (where R^, is Ci-Cgalkyl), or -OSi(R 16 ) 3 [where R 16 , being the same or different, is selected from Ci-Cgalkyl or cyclo(C B -C 8 )alkyl]. 19. A compound according to Claim 18 selected from the group consisting of 7-[O-2-(3-methylbutyl)dimethylsilyl]-iso-baccatin III; 7-(O-tri-n-butylsilyl)-iso-baccatin III; 7-(O-cyclohexyldimethylsilyl)-iso-baccatin III; 7-(O-i-propyldiethylsilyl)-iso-baccatin III; and 7-(O-cycloheptyldimethylsilyl)-iso-baccatin III. 20. A compound of the formula wherein Xa is selected from the group consisting of -H, -C x -C 4 alkyl, -Ci-Cg alkoxy, halo, -Ci-Cg alkylthio, -trifluoromethyl, -C 2 -C 6 dialkylamino, benzyloxymethyl, cyano, azide (N 3 ), or nitro; and wherein R 30 and R^, being the same or different, are selected from the group consisting of -OC(O)C 1 -C 6 alkyl, -OC(O)OC 1 -C 6 alkyl, -OC(O)OCH 2 CX 3 where X is Halo, -OC(O)OCH 2 CH 2 SiR 20 (where ^ is Ci-Cgalkyl), or -OSi(R 16 ) 3 [where R 16 , being the same or different, is selected from Ci-Cgalkyl or cyclo(C 5 -C 8 )alkyl]; with the overall provisio that at least one ao is secondary alkyl or cycloalkyl. 21. A compound according to Claim 20 selected from the group consisting of 7-[O-2-(3-methylbutyl)dimethylsilyl]-baccatin III; 7-(O-tri-n-butylsilyl)-baccatin III; 7-(O-cyclohexyldimethylsilyl)-baccatin III; 7-(O-i-propyldiethylsilyl)-baccatin III; and 7-(O-cycloheptyldimethylsilyl)-baccatin III. 22. A process of preparing which comprises reacting an oxazohdine free acid of Formula 7 with a baccatin compound of Formula 8 in the presence of a dehydrating agent; wherein R 30 and R^, being the same or different, are selected from the group consisting of -OC(O)C 1 -C 6 alkyl, -OC(O)OC 1 -C 6 alkyl, -OC(O)OCH 2 CX 3 where X is Halo, - OC(O)OCH 2 CH 2 SiR 20 (where R^ is Ci-Cgalkyl), or -OSi(R 16 ) 3 [where R 16 , being the same or different, is selected from Ci-Cgalkyl or cyclo(C 5 -C 8 )alkyl]; X 2 is selected from the group consisting of -H, alkyl, -Ci-Cg alkoxy, halo, -Ci-Cg alkylthio, -trifluoromethyl, -C 2 -C 6 dialkylamino, benzyloxymethyl, cyano, azide (N 3 ), or nitro; i is selected from the group consisting of -CH 3 , -CgH B or phenyl substituted with one, 2 or 3 alkyl, Ci-C 8 alkoxy, halo, C j -Cg alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, 2-furyl, 2-thienyl, 1-naphthyl, 2-naphthyl or 3,4-methylenedioxyphenyl; R u is phenyl substituted with -(OCi-CaalkyD n where n is 1 to 3; and R 12 is selected from the group consisting of -C(O)H, -C(O)C 1 -C 10 alkyl, -C(O)phenyl, -C(O)phenyl substituted with one, 2 or 3 C x -C 4 alkyl, C j -Cg alkoxy, halo, alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, -C(O)C(CH 3 )=CHCH 3 , -C(O)OC(CH 3 ) 3 , -C(O)OCH 2 phenyl, -SO 2 -4-methylphenyl, -C(O)(CH 2 ) 3 COOH, -C(O)-4-(SO 3 H)phenyl, -C(O)-l-adamantyl, -C(O)O-3-tetrahydrofuranyl, -C(O)O-4-tetrahydropyranyl, -C(O)CH 2 C(CH 3 ) 3 , -C(O)C(CH 3 ) 3 , -C(O)OC 1 -C 10 alkyl, -C(O)NHC 1 -C 10 alkyl, -C(O)NHPh substituted with one, 2 or 3 Ci-0 4 alkyl, Ci-Cg alkoxy, halo, Cj-Cg alkylthio, trifluoromethyl, C jj -Cg dialkylamino, or nitro, or -C(O)C 3 -C 8 cycloalkyl, -C(O)C(CH 2 CH 3 ) 2 CH 3 , -C(O)C(CH 3 ) 2 CH 2 Cl, -C(O)C(CH 3 ) 2 CH 2 CH 3 , -C(O)-l-phenyl-l-cyclopentyl, -C(O)-l-me hyl- 1-cyclohexyl, -C(S)NHC(CH 3 ) 3 , -C(O)NHCC(CH 3 ) 3 or -C(O)NHPh. 23. Aprocess ofpreparing which comprises reacting an oxazohdine free acid of Formula 7 with a baccatin compound of Formula 8' in the presence of a dehydrating agent; wherein R 30 and R^, being the same or different, are selected from the group consisting of -OC(O)C 1 -C β alkyl, -OC(O)OC 1 -C 6 alkyl, -OC(O)OCH 2 CX 3 where X is Halo, - OC(O)OCH 2 CH 2 SiR 2 o (where R^ is Ci-Cgalkyl), or -OSKR g [where R 16 , being the same or different, is selected from Ci-C 6 alkyl or cyclo(C B -C 8 )alkyl]; X 2 is selected from the group consisting of -H, -Cι-C 4 alkyl, -Ci-C 3 alkoxy, halo, -Cι-C 3 alkylthio, -trifluoromethyl, -C 2 -C 6 dialkylamino, benzyloxymethyl9-end, cyano, azide (N 3 ), or nitro; R x is selected from the group consisting of -CH 3, > -C 6 H 5 or phenyl substituted with one, 2 or 3 Cι-C 4 alkyl, Cι-C 3 alkoxy, halo, Cj-Cg alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, 2-furyl, 2-thienyl, 1-naphthyl, 2-naphthyl or 3,4-methylenedioxyphenyl; R π is phenyl substituted with -(OC 1 -C 2 alkyl) a where n is 1 to 3; and R 12 is selected from the group consisting of -C(O)H, -C(O)Cι-C 10 alkyl, -C(O)phenyl, -C(O)phenyl substituted with one, 2 or 3 Cι-C 4 alkyl, Cι-C 3 alkoxy, halo, alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, -C(O)C(CH 3 )=CHCH 3 , -C(O)OC(CH 3 ) 3 , -C(O)OCH 2 phenyl, -SO 2 -4-methylphenyl, -C(O)(CH 2 ) 3 COOH, -C(O)-4-(SO 3 H)phenyl, -C(O)-l-adamantyl, -C(O)O-3-tetrahydrofαranyl, -C(O)O-4-tetrahydropyranyl, -C(O)CH 2 C(CH 3 ) 3 , -C(O)C(CH 3 )g, -C(O)OC 1 -C 10 alkyl, -CtONHCi-Cioalkyl, -C(O)NHPh substituted with one, 2 or 3 C ! -C 4 alkyl, alkoxy, halo, alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, or nitro, or -C(O)C 3 -C 8 cycloalkyl, -C(O)C(CH 2 CH 3 ) 2 CH 3 , -C(O)C(CH 3 ) 2 CH 2 Cl, -C(O)C(CH 3 ) 2 CH 2 CHg, -C(O)-l-phenyl-l-cyclopentyl, -C(O)-l-methyl- 1-cyclohexyl, -C(S)NHC(CH 3 ) 3 , -C(O)NHCC(CH 3 ) 3 or -C(O)NHPh. 24. A process of preparing which comprises reacting an oxazoline free acid of Formula 7' with a baccatin compound of Formula 8 in the presence of a dehydrating agent; wherein R 30 and R^, being the same or different, are selected from the group consisting of -OC(O)C 1 -C 6 alkyl, -OC(O)OC 1 -C 6 alkyl, -OC(O)OCH 2 CX 3 where X is Halo, - OC(O)OCH 2 CH 2 SiR 2 o (where R^ is Ci-Cgalkyl), or -OSi(R 16 ) 3 [where R^, being the same or different, is selected from Cι-C 6 alkyl or cyclo(C 6 -C 8 )alkyl]; X 2 is selected from the group consisting of -H, -Cι-C 4 alkyl, -Ci-C 3 alkoxy, halo, -Ci-C 3 alkylthio, -trifluoromethyl, -C 2 -C 6 dialkylamino, benzyloxymethyl, cyano, azide (N 3 ), or nitro; Ri is selected from the group consisting of -CH 3 , -C 6 H B or phenyl substituted with one, 2 or 3 Cι-C 4 alkyl, Cι-C 3 alkoxy, halo, Cι-C 3 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, 2-furyl, 2-thienyl, 1-naphthyl, 2-naphthyl or 3,4-methylenedioxyphenyl; and R' l i is selected from the group consisting of -Cι-C 10 alkyl, -phenyl, -phenyl substituted with one, 2 or 3 C r C 4 alkyl, Cι-C 3 alkoxy, halo, Cι-C 3 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, -1-adamantyl, -3-tetrahydrofuranyl, -4-tetrahydropyranyl, or -CH 2 C(CH 3 ) 3 . 25. A process of preparing which comprises reacting an oxazoline free acid of Formula 7' with a baccatin compound of Formula 8' in the presence of a dehydrating agent; wherein R 30 and R^, being the same or different, are selected from the group consisting of -OC(O)Cι-C 6 alkyl, -OC(O)OCι-C 6 alkyl, -OC(O)OCH 2 CX 3 where X is Halo, - OC(O)OCH 2 CH 2 SiRa 0 (where R^ is Cι-C 6 alkyl), or -OSi(R 16 ) 3 [where R 16 , being the same or different, is selected from Cj-Cgalkyl or cyclo(C B -C 8 )alkyl]; X 2 is selected from the group consisting of -H, -Cι-C 4 alkyl, -Ci-C 3 alkoxy, halo, -Ci-C 3 alkylthio, -trifluoromethyl, -C 2 -C 6 dialkylamino, benzyloxymethyl, cyano, azide (N 3 ), or nitro; Ri is selected from the group consisting of -CH 3 , -CgHg or phenyl substituted with one, 2 or 3 C r C 4 alkyl, Cι-C 3 alkoxy, halo, Ci-C 3 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, 2-furyl, 2-thienyl, 1-naphthyl, 2-naphthyl or 3,4-methylenedioxyphenyl; and R'ii is selected from the group consisting of -Ci-C 10 alkyl, -phenyl, -phenyl substituted with one, 2 or 3 Ci-C 4 alkyl, Cι-C 3 alkoxy, halo, Cι-C 3 alkylthio, trifluoromethyl, C 2 -C 6 dialkylamino, hydroxy or nitro, -1-adamantyl, -3-tetrahydrofuranyl, -4-tetrahydropyranyl, or -CH 2 C(CH 3 ) 3 . 26. A compound according to Claim 1 wherein 1^ is -NHC(O)NHC(CH 3 ) 3 , Ri is phenyl or substituted phenyl, R 4 is hydroxy, and Rg and R B are -H. 27. A compound of the formula:

Inventors: KELLY ROBERT C, WICNIENSKI NANCY ANNE, WUTS PETER G M, KELLY, ROBERT, C., WICNIENSKI, NANCY, ANNE, WUTS, PETER, G., M.
Applicants: KELLY ROBERT C, UPJOHN CO, WICNIENSKI NANCY ANNE, WUTS PETER G M, KELLY, ROBERT, C., THE UPJOHN COMPANY, WICNIENSKI, NANCY, ANNE, WUTS, PETER, G., M.
Application year: 1995
Main classification: C07D305
IPC codes: A61K31, A61P35, C07D305, C07D407, C07D413