CYCLIC HEXAPEPTIDES HAVING ANTIBIOTIC ACTIVITY

Abstract: This invention relates to new polypeptide compounds represented by formula (I), wherein R<1> is as defined in the description and pharmaceutically acceptable salt thereof which have antimicrobial activities (especially, antifungal activities), inhibitory activity on beta -1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.

Description: DESCRIPTION Cyclic hexapeptldes having antibiotic activity TECHNICAL FIELD The present invention relates to new polypeptide compound and a pharmaceutically acceptable salt thereof which are useful as a medicament. BACKGROUND ART In U.S. Pat. No. 5,376,634/ there are disclosed the polypeptide compound and a pharmaceutically acceptable salt thereof, which have antimicrobial activities (especially antifungal activity) . DISCLOSURE OF INVENTION The present invention relates to new polypeptide compound and a pharmaceutically acceptable salt thereof. More particularly, it relates to new polypeptide compound and a pharmaceutically acceptable salt thereof, which have antimicrobial activities [especially, antifungal activities, in which the fungi may include Asperσillus. rryptococcus. Candid , _______£, Actinomyrp.ς. Histoolasma. Dermatophvte. Malassezia. Fusarium and the like.], inhibitory activity on β -l,3-glucan synthase, and further which are expected tc be useful for the prophylactic and/or therapeutic treatment of Pneumocystis carinii infection (e.g. PneiMP-CCystis carinii pneumonia) in a human being or an animal, to a process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis ςarjnii infection (e.g. Pneumocystis carinii pneumonia) in a human being cr an animal. The object polypeptide compound used in the present invention are new and can be represented by the following general formula [I] : wherein R 1 is lower alkanoyl substituted with unsaturated 6-membered heteromonocyclic group containing at least one nitrogen atom which may have one or more suitable substituent (s) ; lower alkanoyl substituted with 1,2,3,4- tetrahydroisoquinoline which may have one or more suitable substituent (s) ; lower alkanoyl substituted with unsaturated condensed heterocyclic group containing at least one oxygen atom which may have one or more suitable substituent (s) ; lower alkanoyl substituted with unsaturated condensed heterocyclic group containing 1 to 3 sulfur atom(s) which may have one or more suitable substituent (s) ; lower alkanoyl substituted with unsaturated condensed heterocyclic group containing 2 or more nitrogen atom(s) which may have one or more suitable substituent (s) ; 5 lower alkanoyl substituted with saturated 3 to 8 membered heteromonocyclic group containing at least one nitrogen atom which may have one or more suitable substituent (s) ; 10 ar(lower)alkenoyl substituted with aryl which may have one or more suitable substituent (s) ; naphthyl (lower)alkenoyl which may have one or more higher alkoxy; 15 lower alkynoyl which may have one or more suitable substituent(s) ; (C2~Cg) alkanoyl substituted with naphthyl having higher alkoxy; ar(C2~Cg)alkanoyl substituted with aryl 20 having one or more suitable substituent (s) , in which ar C2~C β )alkanoyl may have one or more suitable substituent(s) ; aroyl substituted with heterocyclic group which may have one or more suitable 25 substituent (s) , in which aroyl may have one or more suitable substituent (s) ; aroyl substituted with aryl having heterocyclic(higher)alkoxy, in which heterocyclic group may have one or more 30 suitable substituent (s) ; aroyl substituted with aryl having lower alkoxy(higher)alkoxy; aroyl substituted with aryl having lower alkenyl (lower)alkoxy; 35 aroyl substituted with 2 lower alkoxy; aroyl substituted with aryl having lower alkyl; aroyl substituted with aryl having higher alkyl; 5 aryloxy(lower)alkanoyl which may have one or more suitable substituent (s) ; ar (lower) alkoxy(lower) alkanoyl which may have one or more suitable substituent (s; ; arylamino(lower) alkanoyl which may have 10 one or more suitable substituent (s) ; lower alkanoyl substituted with pyrazolyl which has lower alkyl and aryl having higher alkoxy; lower alkoxy(higher) alkanoyl, in which 15 higher alkanoyl may have one or more suitable substituent(s) ; aroyl substituted with aryl having heterocyclicoxy, in which heterocyclicoxy may have one or more suitable 20 substituent (s) ; aroyl substituted with cycio(lower)alkyl having lower alkyl; indolylcarbonyl having higher alkyl; naphthoyl having lower alkyl; 25 naphthoyl having higher alkyl; naphthoyl having lower alkoxy(higher) alkoxy; aroyl substituted with aryl having lower alkoxy(lower)alkoxy(higher)alkoxy; 30 aroyl substituted with aryl having lower alkoxy(lower)alkoxy; aroyl substituted with aryl which has aryl having lower alkoxy; aroyl substituted with aryl which has aryl 35 having lower alkoxy(lower)alkoxy; aroyl substituted with aryl having heterocyclicoxy (higher) alkoxy; aroyl substituted with aryl having aryloxy(lower) alkoxy; aroyl substituted with aryl having heterocycliccarbonyl (higher) alkoxy; lower alkanoyl substituted with oxazolyl which has aryl having higher alkoxy; lower alkanoyl substituted with furyl which has aryl substituted with aryl having lower alkoxy; lower alkanoyl substituted with triazolyl which has oxo and aryl having higher alkyl; higher alkanoyl having hydroxy; higher alkanoyl having ar (lower) alkyl and hydroxy; 3-methyl-tridecenoyl; or (C2 _ Cg) alkanoyl substituted with aryl having higher alkoxy, in which (C 6 - Cg) alkanoyl may have amino or protected amino. The new polypeptide compound [IJ and a pharmaceutically acceptable salt thereof can be prepared by the process as illustrated in the following reaction scheme or can be prepared by elimination reaction of amino protective group in R . Process 1 or its reactive derivative at the ammo group or a salt thereof or a salt thereof wherein R-*- is as defined above. Suitable pharmaceutically acceptable salts of the object polypeptide compound [I] are conventional non-toxic salts and may include a salt with a base or an acid addition salt such as a salt with an inorganic base, for example, an alkali metal salt (e.g., sodium salt, potassium salt, etc.), an alkaline earth metal salt (e.g., calcium salt, magnesium salt, etc.), an ammonium salt; a salt with an organic base, for example, an organic amine salt (e.g., triethylamine salt, pyridine salt, picoline salt, ethanolamine salt, triethanolamine salt, dicyclohexylamine salt, N,N'-dibenzylethylenediamine salt, etc.); an inorganic acid addition salt (e.g., hydrochloride, hydrobromide, sulfate, phosphate, etc.); an organic carboxylic sulfonic acid addition salt (e.g., formate, acetate, trifluoroacetate, maleate, tartrate, fumarate, methanesulfonate, benzenesulfonate, toluenesulfonate, etc.); a salt with a basic or acidic amino acid (e.g., arginine, aspartic acid, glutamic acid, etc. ) . In the above and subsequent descriptions of the present specification, suitable examples and illustration of the various definitions which the present invention intends to include within the scope thereof are explained in detail as follows. The term "lower" is used to intend a group having 1 to 6 carbon atom(s), unless otherwise provided. The term "higher" is used to intend a group having 7 to 20 carbon atoms, unless otherwise provided. Suitable example of "one or more" may be the number of 1 to 6, in which the preferred one may be the number of 1 to 3. Suitable example of "lower alkanoyl" may include straight or branched one such as formyl, acetyl, 2-methylacetyl, 2, 2-dimethylacetyl, propionyl, butyryl, isobutyryl, pentanoyl, 2, 2-dimethylpropionyl, hexanoyl, and the like. Suitable example of "suitable substituent (s) " in the groups such as "lower alkanoyl substituted with unsaturated 6-membered heteromonocyclic group containing at least one nitrogen atom which may have one or more suitable substituent (s) ", "lower alkanoyl substituted with 1, 2, 3, 4-tetrahydroisoquinoline which may have one or more suitable substituent (s) ", etc. may include lower alkoxy as mentioned below, higher alkoxy as mentioned below, lower alkyl as mentioned below, higher alkyl as mentioned below, higher alkoxy (lower) alkyl, lower alkoxycarbonyl, oxo, aryl which may have one or more lower alkoxy, aryl which may have one or more higher alkoxy, aryl which may have one or more lower alkyl, aryl which may have one or more higher alkyl, aryl substituted with aryl which may have one or more lower alkoxy, aryl substituted with aryl which may have one or more higher alkoxy, aryl substituted with aryl which may have one or more lower alkyl, aryl substituted with aryl which may have one or more higher alkyl, aroyl which may have one or more lower alkoxy, aroyl which may have one or more higher alkoxy, aroyl which may have one or more lower alkyl, aroyl which may have one or more higher alkyl, heterocyclic group which may have one or more lower alkoxy, heterocyclic group which may have one or more higher alkoxy, aryl having heterocyclic (higher) alkoxy, heterocyclic group which may have aryl having higher alkoxy, heterocyclic group which may have aryl having lower alkoxy(higher) alkoxy, heterocyclic group which may have aryl having lower alkoxy, lower alkoxy (lower) alkyl, halo (lower) alkoxy, lower alkenyloxy, halo (higher) alkoxy, lower alkoxy (higher) alkoxy, aryl which may have one or more lower alkoxy(lower) alkoxy, heterocyclic group, aryl which may have one or more lower alkoxy(higher)alkoxy, aryl which may have one or more higher alkenyloxy, cyclo(lower)alkyl which may have aryl, aryl substituted with heterocyclic group which may have lower alkyl and oxo, cyclo(lower)alkyl which may have one or more lower alkyl, aryl which may have cyclo (lower) alkyl, aryl which may have heterocyclic group, and the like. Suitable example of "lower alkoxy" may include straight or branched one such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, tert-butoxy, pentyloxy, tert-pentyloxy, neo-pentyloxy, hexyloxy, isohexyloxy and the like, in which the preferred one may be methoxy, ethoxy, propoxy, butoxy, pentyloxy, hexyloxy and isohexyloxy. Suitable example of "higher alkoxy" may include straight or branched one such as heptyloxy, octyloxy, 3, 5-dimethyloctyloxy, 3 , 7-dimethyloctyloxy, nonyloxy, decyloxy, undecyloxy, dodecyloxy, tridecyloxy, tetradecyloxy, hexadecyloxy, heptadecyloxy, octadecyloxy, nonadecyloxy, icosyloxy, and the like, in which the preferred one may be (C 7 -C14)alkoxy, and the more preferred one may be heptyloxy and octyloxy. Suitable example of "lower alkyl" may include straight or branched one having 1 to 6 carbon atom(s), such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, tert-pentyl, neo-pentyl, hexyl, isohexyl and the like, in which the preferred one may be methyl, pentyl, hexyl and isohexyl. Suitable example of "higher alkyl" may include straight or branched one having 7 to 20 carbon atoms, such as heptyl, octyl, 3, 5-dimethyloctyl, 3, 7-dimethyloctyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, icosyl, and the like, in which the preferred one may be (C7-C ) alkyl, and the more preferred one may be heptyl, octyl, nonyl and decyl. Suitable example of "aryl" and "ar" moiety may include phenyl which may have lower alkyl (e.g., phenyl, mesityl, tolyl, etc.), naphthyl, anthryl, and the like, in which the preferred one may be phenyl and naphthyl. Suitable example of "aroyl" may include benzoyl, toluoyl, naphthoyl, anthrylcarbonyl, and the like, in which the preferred one may be benzoyl and naphthoyl. Suitable example of "heterocyclic group" and "heterocyclic" moiety may include unsaturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing 1 to 4 nitrogen atom(s), for example, pyrrolyl, pyrrolinyl, imidazolyl, pyrazolyl, pyridyl, dihydropyridyl, pyrimidyl, pyrazinyl, pyridazinyl, triazolyl (e.g., 4H-1,2,4- triazolyl, 1H-1,2, 3-triazolyl, 2H-1,2, 3-triazolyl, etc.), tetrazolyl (e.g., lH-tetrazolyl, 2H-tetrazolyl, etc.), etc. ; saturated 3 to 8-membered (more preferably 5 or 6- membered heteromonocyclic group containing 1 to 4 nitrogen atom(s), for example, pyrrolidinyl, imidazolidinyl, piperidyl, piperazinyl, etc.; unsaturated condensed heterocyclic group containing 1 to 4 nitrogen atom(s), for example, indolyl, isoindolyl, indolinyl, indolizinyl, benzimidazolyl, quinolyl, isoquinolyl, indazolyl, benzotriazolyl, etc.; unsaturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing 1 to 2 oxygen atom(s) and 1 to 3 nitrogen atom(s), for example, oxazolyl, isoxazolyl, oxadiazolyl (e.g., 1,2,4- oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,5-oxadiazolyl, etc.), etc.; saturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing 1 to 2 oxygen atom(s) and 1 to 3 nitrogen atom(s), for example, morpholinyl, sydnonyl, etc.; unsaturated condensed heterocyclic group containing 1 to 2 oxygen atom(s) and 1 to 3 nitrogen atom(s), for example, benzoxazolyl, benzoxadiazolyl, etc.; unsaturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing 1 to 2 sulfur atom(s) and 1 to 3 nitrogen atom(s), for example, thiazolyl, isothiazolyl, thiadiazolyl (e.g., 1,2,3- thiadiazolyl, 1,2, 4-thiadiazolyl, 1, 3, -thiadiazolyl, 1,2, 5-thiadiazolyl, etc.), dihydrothiazinyl, etc.; saturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing 1 to 2 sulfur atom(s) and 1 to 3 nitrogen atom(s), for example, thiazolidinyl, etc.; unsaturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing 1 to 2 sulfur atom(s), for example, thienyl, dihydrodithiinyl, dihydrodithionyl, etc.; unsaturated condensed heterocyclic group containing 1 to 2 sulfur atom(s) and 1 to 3 nitrogen atom(s), for example, benzothiazolyl, benzothiadiazolyl, etc.; unsaturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing an oxygen atom, for example, furyl, etc.; saturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing an oxygen atom, for example, tetrahydrofuran, tetrahydropyran, etc.; unsaturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing an oxygen atom and 1 to 2 sulfur atom(s), for example, dihydrooxathiinyl, etc. ; unsaturated condensed heterocyclic group containing 1 to 2 sulfur atom(s), for example, benzothienyl, benzodithiinyi, etc.; unsaturated condensed heterocyclic group containing an oxygen atom and 1 to 2 sulfur atom(s), for example, benzoxathiinyl, etc.; and the like. Suitable example of "halo" may include fluoro, chioro, bromo and iodo. Suitable example of "lower alkenyloxy" may include vinyloxy, l-(or 2-)propenyloxy, l-(or 2- or 3-) utenyloxy, 1- (or 2- or 3- or 4-)pentenyloxy, l-(or 2- or 3- or 4- or 5-; exenyloxy, and the like, in which the preferred one may be (C--Cg) alkenyloxy, and the most preferred one may be 5-hexenyloxy. Suitable example of "higher alkenyloxy" may include (C -C20' alkenyloxy, in which the preferred one may be 6- heptenyloxy and 7-octenyloxy. Suitable example of "cyclo (lower) alkyl" may include cyclopropyl, cyciobutyl, cyclopentyl, cycichexyi, and the like, in which the preferred one may be cyclo (C^-Cg)alkyl, and the most preferred one may be cyclohexyl. Suitable example of "higher alkanoyl" may include heptanoyl, octanoyl, nonanoyl, decanoyl, undecanoyl, lauroyl, tridecanoyl, tetradecanoyl, pentadecanoyl, hexadecanoyl, heptadecanoyl, octadecanoyl, nonadecanoyl, icosanoyl, and the like, in which the preferred one may be (C^-C- JQ ) alkanoyl, and the most preferred one may be hexadecanoyl. Suitable example of "ar(lower) alkyl" may include benzyl, phenethyl, phenylpropyl, phenylbutyl, phenylpentyl, phenylhexyl, naphthylmethyl, naphthylethyl, naphthylpropyl, naphthylbutyl, naphthylpentyl, naphthylhexyl, and the like, in which the preferred one may be phenyl (C^-C^)alkyl, and the most preferred one may be benzvl. Suitable example of "protected amino" may include lower or higher alkoxycarbonylamino (e.g., methoxycarbonylamino, ethoxycarbonylamino, t-butoxycarbonylamino, t-pentyloxycarbonylamino, heptyloxycarbonylamino, etc.), ar(lower) alkoxycarbonylamino [e. q . f phenyl (lower) alkoxycarbonylamino (e.g., benzyloxycarbonylamino, etc.), etc.], an amino group substituted with a conventional protecting group such as ar(lower) alkyl which may have suitable substituent (s) (e.g., benzyl, trityl, etc.) and the like, in which the preferred one may be phenyl (lower)alkoxycarbonylamino, and the most preferred one may be benzyloxycarbonylamino. Suitable example of "lower alkanoyl" in the term of "lower alkanoyl substituted with unsaturated 6-me bered heteromonocyclic group containing at least one nitrogen atom which may have one or more suitable substituent (s) " can be referred to aforementioned "lower alkanoyl", in which the preferred one may be Z^ -C^ ) alkanoyl, and the more preferred one may be formyl. Suitable example of "unsaturated 6-membered heteromonocyclic group containing at least one nitrogen atom" in the term of "lower alkanoyl substituted with unsaturated 6-membered heteromonocyclic group containing at least one nitrogen atom which may have one or more suitable substituent (s) " may include pyridyl, dihydropyridyl, pyrimidyl, pyrazinyl, pyridazinyl, triazinyl (e.g., 4H-1,2, -triazinyl, 1H-1,2,3-triazinyl, etc.), tetrazinyl (e.g., 1,2,4,5-tetrazinyl, 1,2,3,4- tetrazinyl, etc.), and the like, in which the preferred one may be unsaturated 6-membered heteromonocyclic group containing 1 to 3 nitrogen atom(s), and the most preferred one may be pyridyl and pyridazinyl. Suitable example of "suitable substituent (s) " in the term of "lower alkanoyl substituted with unsaturated 6-membered heteromonocyclic groups containing at least one nitrogen atom which may have one or more suitable substituent (s) " can be referred to aforementioned "suitable substituent (s) ", in which the preferred one may be higher alkoxy, higher alkoxy(lower)alkyl, heterocyclic group which may have aryl having higher alkoxy, aryl which may have one or more higher alkoxy, aryl substituted with aryl which may have lower alkoxy, heterocyclic group which may have aryl having lower alkoxy(higher)alkoxy, and heterocyclic group which may have aryl having lower alkoxy, and the more preferred one may be (C7-C14)alkoxy, (C7-C14)alkoxy- (C1 . -C4)alkyl, 3 to 8-membered saturated heteromonocyclic group containing at least one nitrogen atom which may have phenyl having 1 to 3 (C 7 -C-L4)alkoxy, phenyl which may have 1 to 3 (C7-C 4)alkoxy, phenyl substituted with phenyl which may have 1 to 3 (C3~C )alkoxy, 3 to 8-membered saturated heteromonocyclic group containing at least one nitrogen atom which may have phenyl having (C-^-C^ ) - alkoxy(07-0 4)alkoxy, and 3 to 8-membered saturated heteromonocyclic group containing at least one nitrogen atom which may have phenyl having 1 to 3 (C 3 -Cg)alkoxy, and the most preferred one may be octyloxy, octyloxymethyl, piperazinyl which has phenyl having heptyloxy or octyloxy, phenyl having heptyloxy, phenyl substituted with phenyl having butoxy, piperazinyl which has phenyl having methoxyoctyloxy, and piperazinyl which has phenyl having hexyloxy. Suitable example of "lower alkanoyl" in the term of "lower alkanoyl substituted with 1,2,3,4-tetra- hydroisoquinoline which may have one or more suitable substituent(s) " can be referred to aforementioned "lower alkanoyl", in which the preferred one may be (C -C4)- alkanoyl, and the more preferred one may be formyl. Suitable example of "suitable substituent (s) " in the term of "lower alkanoyl substituted with 1,2,3,4- tetrahydroisoquinoline which may have one or more suitable substituent (s) " can be referred to aforementioned "suitable substituent (s) ", in which the preferred one may be lower alkoxy, higher alkoxy, lower alkyl, higher alkyl and lower alkoxycarbonyl, and the more preferred one may be (C 7 -C24)alkoxy and (C2-C4)alkoxycarbonyl, and the most preferred one may be octyloxy and tert-butoxycarbonyl. Suitable example of "lower alkanoyl" in the term of "lower alkanoyl substituted with unsaturated condensed heterocyclic group containing at least one oxygen atom which may have one or more suitable substituent (s) " can be referred to aforementioned "lower alkanoyl", in which the preferred one may be (C -C4) alkanoyl, and the more preferred one may be formyl. Suitable example of "unsaturated condensed heterocyclic group containing at least one oxygen atom" in the term of "lower alkanoyl substituted with unsaturated condensed heterocyclic group containing at least one oxygen atom which may have one or more suitable substituent (s) " may include unsaturated condensed heterocyclic group containing one or more oxygen atom(s) and, optionally, another hetero atom(s) except oxygen atom, in which the preferred one may be unsaturated condensed heterocyclic group containing 1 to 3 oxygen atom(s), unsaturated condensed heterocyclic group containing 1 to 2 oxygen atom(s) and 1 to 2 sulfur atom(s) and unsaturated condensed heterocyclic group 1 to 3 oxygen atom(s) and 1 to 3 nitrogen atom(s), and the more preferred one may be benzo[b] furanyl, isobenzofuranyl, chromenyl, xanthenyl, benzoxazolyl, benzoxadiazolyl, dihydrooxathiinyl, phenoxathiinyl, and the like, and the most preferred one may be benzo[b] furanyl, chromenyl and benzoxazolyl. Suitable example of "suitable substituent (s) " in the term of "lower alkanoyl substituted with unsaturated condensed heterocyclic group containing at least one oxygen atom which may have one or more suitable substituent(s) " can be referred to aforementioned "suitable substituent (s) ", in which the preferred one may be lower alkoxy, higher alkoxy, lower alkyl, higher alkyl, oxo, aryl which may have one or more lower alkoxy, heterocyclic group which may have one or more higher alkoxy, and aryl substituted with aryl which may have one or more lower alkyl, and the more preferred one may be (C7-C24)alkoxy, (C -C4)alkyl, (C7-C24)alkyl, oxo, phenyl which may have 1 to 3 (C 3 -Cg)alkoxy, unsaturated 6-membered heteromonochclic group containing at least one nitrogen atom which may have 1 to 3 (C 7 -C24)alkoxy, and phenyl substituted with phenyl which may have 1 to 3 (C3~Cg)alkyl, and the most preferred one may be octyloxy, methyl, nonyl, oxo, phenyl having hexyloxy, pyridyl having octyloxy, and phenyl substituted with phenyl having hexyl. Suitable example of "lower alkanoyl" in the term of "lower alkanoyl substituted with unsaturated condensed heterocyclic group containing 1 to 3 sulfur atom(s) which may have one or more suitable substituent(s) " can be referred to aforementioned "lower alkanoyl", in which the preferred one may be (C -C4)alkanoyl, and the more preferred one may be formyl. Suitable example of "unsaturated condensed heterocyclic group containing 1 to 3 sulfur atom(s)" in the term of "lower alkanoyl substituted with unsaturated condensed heterocyclic group containing 1 to 3 sulfur atom(s) which may have one or more suitable substituent (s) " may include unsaturated condensed heterocyclic group containing only 1 to 3 sulfur atom(s), in which the preferred one may be benzothienyl and benzodithiinyl, and the most preferred one may be benzothienyl. Suitable example of "suitable substituent (s) " in the term of "lower alkanoyl substituted with unsaturated condensed heterocyclic group containing 1 to 3 sulfur atom(s) which may have one or more suitable substituent (s) " can be referred to aforementioned "suitable substituent (s) ", in which the preferred one may be lower alkoxy, higher alkoxy, lower alkyl and higher alkyl, and more preferred one may be (C7-C24) alkoxy, and the most preferred one may be octyloxy. Suitable example of "lower alkanoyl" in the term of "lower alkanoyl substituted with unsaturated condensed heterocyclic group containing 2 or more nitrogen atom(s) which may have one or more suitable substituent (s) " can be referred to aforementioned "lower alkanoyl", in which the preferred one may be (C -C4)alkanoyl, and the most preferred one may be formyl. Suitable example of "unsaturated condensed heterocyclic group containing 2 or more nitrogen atom(s)" in the term of "lower alkanoyl substituted with unsaturated condensed heterocyclic group containing 2 or more nitrogen atom(s) which may have one or more suitable substituent (s) " may include lH-indazolyl, purinyl, phthalazinyl, benzoimidazolyl, naphthyridinyl, quinoxalinyl, quinazolyl, cinnolinyl, peteridinyl, and the like, in which the most preferred one may be benzoimidazolyl. Suitable example of "suitable substituent (s) " in the term of "lower alkanoyl substituted with unsaturated condensed heterocyclic group containing 2 or more nitrogen atom(s) which may have one or more suitable substituent (s) " can be referred to aforementioned "suitable substituent (s) ", in which the preferred one may be lower alkoxy, higher alkoxy, lower alkyl, higher alkyl, aryl which may have one or more lower alkoxy and aryl which may have one or more higher alkoxy, and the more preferred one may be (C 7 - C 4) alkyl and phenyl which may have 1 to 3 (C -C ) alkoxy, and the most preferred one may be nonyl and phenyl which may have hexyloxy. Suitable example of "lower alkanoyl" in the term of "lower alkanoyl substituted with saturated 3 to 8-membered heteromonocyclic group containing at least one nitrogen atom which may have one or more suitable substituent (s) " can be referred to aforementioned "lower alkanoyl", in which the preferred one may be (C*ι-C4)alkanoyl, and the more preferred one may be formyl. Suitable example of "saturated 3 to 8-membered heteromonocyclic group containing at least one nitrogen atom" in the term of "lower alkanoyl substituted with saturated 3 to 8-membered heteromonocyclic group containing at least one nitrogen atom which may have one or more suitable substituent (s) " may include pyrrolidinyl, imidazolidinyl, piperidyl, piperazinyl, pyrazolidinyl, morpholinyl, thiomorpholinyl, and the like, in which the preferred one may be piperidyl and piperazinyl. Suitable example of "suitable substituent (s) " in the term of "lower alkanoyl substituted with saturated 3 to 8- membered heteromonocyclic group containing at least one nitrogen atom which may have one or more suitable substituent (s) " may include lower alkoxy, higher alkoxy, higher alkoxy(lower) alkyl, lower alkyl, higher alkyl, oxo, aryl which may have one or more lower alkoxy, aryl which may have one or more higher alkoxy, aryl which may have one or more lower alkyl, aryl which may have one or more higher alkyl, aroyl which may have one or more lower alkoxy, aroyl which may have one or more higher alkoxy, aroyl which may have one or more lower alkyl, aroyl which may have one or more higher alkyl, and the like, in which the preferred one may be aryl which may have one or more lower alkoxy, aryl which may have one or more higher alkoxy, aroyl which may have one or more lower alkoxy and aroyl which may have one or more higher alkoxy, and the more preferred one may be aryl which may have 1 to 3 higher alkoxy and aroyl which may have 1 to 3 higher alkoxy, and the much more preferred one may be phenyl which may have 1 to 3 (C7-C24) alkoxy and naphthoyl which may have 1 to 3 (C7-C24)alkoxy, and the most preferred one may be phenyl which may have octyloxy and naphthoyl which may have heptyloxy. Suitable example of "ar(lower)alkenoyl" in the term of "ar(lower) alkenoyl substituted with aryl which may have one or more suitable substituent (s) " may include phenyl (lower) alkenoyl (e.g., 3-phenylacryloyl, (2- or 3- or 4-)phenyl- (2- or 3-)butenoyl, 3-phenylmethacryloyl, (2- or 3- or 4- or 5-)phenyl- (2- or 3- or 4-)pentanoyl, (2- or 3- or 4- or 5- or 6-)phenyl- (2- or 3- or 4- or 5-)- hexanoyl, etc.), naphthyl (lower)alkenoyl (e.g., 3-naphthylacryloyl, (2- or 3- or 4-)naphthyl-(2- or 3-)butenoyl, (2- or 3- or 4- or 5-)naphthyl- (2- or 3- or 4-)pentanoyl, (2- or 3- or 4- or 5- or 6-)naphthyl- (2- or 3- or 4- or 5-)hexanoyl, etc.), and the like, in which the preferred one may be 3-phenylacryloyl and 3- methyl-3-phenylacryloyl. Suitable example of "suitable substituent (s) " in the term of "ar (lower) alkenoyl substituted with aryl which may have one or more suitable substituent (s) " can be referred to aforementioned "suitable substituent (s) ", in which the preferred one may be lower alkoxy, lower alkyl, higher alkyl, lower alkoxy(lower) alkyl, halo (lower) alkoxy, lower alkenyloxy, halo (higher) alkoxy, and lower alkoxy (higher) alkoxy and the much more preferred one may be (Cι~C ) alkoxy, (C ~Cg) alkyl, (C7-C2 ) alkyl, (C2-C4) alkoxy(C 3 -Cg) alkyl, halo (C 3 -Cg) alkoxy, (C3- Cg) alkenyloxy, halo (C7-C24) alkoxy, and (C-* _C^ ) alkoxy (C7- c i4 ' alkoxy and the most preferred one may be pentyloxy, heptyl, pentyl, methoxyhexyl, fluorohexyloxy, isohexyloxy, 5-hexenyloxy, haloheptyloxy, ethoxyheptyloxy, methoxyoctyloxy, and butyloxy. Suitable example of "naphthyl (lower) alkenoyl" in the term of "naphthyl (lower) alkenoyl which may have one or more higher alkoxy" may include 3-naphthylacryloyl, (2- or 3- or 4-) naphthyl- (2- or 3-)butenoyl, (2- or 3- or 4- or 5-) naphthyl- (2- or 3- or 4-)pentanoyl, (2- or 3- or 4- or 5- or 6-) naphthyl- (2- or 3- or 4- or 5-)hexanoyl, and the like, in which the preferred one may be 3-naphthylacryloyl . Suitable example of "lower alkynoyl" in the term of "lower alkynoyl which may have one or more suitable substituent (s) " may include 2-propynoyl, (2- or 3-)butynoyl, (2- or 3- or 4-)pentynoyl, (2- or 3- or 4- or 5-)hexynoyl, and the like, in which the preferred one may be 2-propynoyl. Suitable example of "suitable substituent (s) " in the term of "lower alkynoyl which may have one or more suitable substituent (s) " can be referred to aforementioned "suitable substituent (s) ", in which the preferred one may be aryl which may have one or more lower alkoxy, aryl which may have one or more higher alkoxy, aryl substituted with aryl which may have one or more lower alkyl and aryl substituted with aryl which may have one or more higher alkyl, and the more preferred one may be aryl substituted with aryl which may have 1 to 3 lower alkyl and aryl which may have 1 to 3 higher alkoxy, and the much more preferred one may be phenyl substituted with phenyl which may have 1 to 3 (C2~ Cg) alkyl and phenyl which may have 1 to 3 (C7-C24) alkoxy, and the most preferred one may be phenyl substituted with phenyl which may have pentyl and naphthyl which may have heptyloxy. Suitable example of "ar(C2~Cg) alkanoyl" in the term of "ar (C2~Cg) alkanoyl substituted with aryl having one or more suitable substituent (s) , in which ar(C 7 -Cg) alkanoyl may have one or more suitable substituent (s) " may include phenyl (C2~C )alkanoyl [e.g., phenylacetyl, (2- or 3-)- phenylpropanoyl, (2- or 3- or 4-)phenylbutanoyl, (2- or 3- or 4- or 5-)phenylpentanoyl, (2- or 3- or 4- or 5- or 6-)- phenylhexanoyl, etc.], naphthyl (C2~Cg)alkanoyl [e.g. naphthylacetyl, (2- or 3-)naphthylpropanoyl, (2- or 3- or 4-)naphthylbutanoyl, (2- or 3- or 4- or 5-)- naphthylpentanoyl, (2- or 3- or 4- or 5- or 6-)- naphthylhexanoyl, etc.], and the like, in which the preferred one may be 2-phenylacetyl and 3-phenylpropanoyl. Suitable example of "suitable substituent (s) " in the term of "ar(C2~Cg)alkanoyl substituted with aryl having one or more suitable substituent (s) , in which ar(C 2 -Cg)- alkanoyl may have one or more suitable substituent (s) " may include lower alkoxy, higher alkoxy, lower alkyl, higher alkyl, higher alkoxy (lower) alkyl, oxo, aryl having one or more lower alkoxy, aryl having one or more higher alkoxy, aryl having one or more lower alkyl, aryl having one or more higher alkyl, aryl substituted with aryl having one or more lower alkoxy, aryl substituted with aryl having one or more higher alkoxy, aryl substituted with aryl having one or more lower alkyl, aryl substituted with aryl having one or more higher alkyl, aryl having one or more lower alkoxy (lower) alkoxy and the like, in which the preferred one may be lower alkoxy, higher alkoxy, lower alkyl, higher alkyl, and phenyl having 1 to 3 lower alkoxy(lower) alkoxy and the much more preferred one may be (C ~C ) alkoxy, (Cι~Cg) alkyl, (C7-C2 ) alkyl and phenyl having (C2-C4) alkoxy (C 3 -Cg) alkoxy and the most preferred one may be pentyloxy, pentyl, heptyl and phenyl having methoxypentyloxy. Suitable example of "suitable substituent (s) " in the term of "in which ar (C2~C ) alkanoyl may have one or more suitable substituent (s) " may be hydroxy, oxo, amino and aforementioned "protected amino". Suitable example of " (C2-C5) alkanoyl" in the term of " (C2~Cg) alkanoyl substituted with naphthyl having higher alkoxy" may include acetyl, propanoyl, butanoyl, pentanoyl, hexanoyl, and the like, in which the preferred one may be propanoyl. Suitable example of "higher alkoxy" in the term of " (C2~Cg) alkanoyl substituted with naphthyl having higher alkoxy" can be referred to aforementioned "higher alkoxy", in which the preferred one may be (C7-C ) alkoxy, and the most preferred one may be heptyloxy. Suitable example of "aroyl" in the term of "aroyl substituted with heterocyclic group which may have one or more suitable substituent (s) , in which aroyl may have one or more suitable substituent(s) " may include benzoyl, toluoyl, naphthoyl, and the like, in which the preferred one may be benzoyl. Suitable example of "heterocyclic group" in the term of "aroyl substituted with heterocyclic group which may have one or more suitable substituent (s) , in which aroyl may have one or more suitable substituent (s) " may include unsaturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing 1 to 4 nitrogen atorn(s), for example, pyrrolyl, pyrrolinyl, imidazolyl, pyrazolyl, pyridyl, dihydropyridyl, pyrimidyl, pyrazinyl, pyridazinyl, triazolyl (e.g., 4H-1,2,4- triazolyl, 1H-1,2, 3-triazolyl, 2H-1,2, 3-triazolyl, etc.), tetrazolyl (e.g., IH-tetrazolyl, 2H-tetrazolyl, etc.), etc. ; saturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing 1 to 4 nitrogen atom(s), for example, pyrrolidinyl, imidazolidinyl, piperidyl, piperazinyl, etc.; unsaturated condensed heterocyclic group containing 1 to 4 nitrogen atom(s), for example, indolyl, isoindolyl, indolin:_, indolizinyl, benzimidazolyl, quinolyl, isoquinolyl, indazolyl, benzotriazolyl, etc.; unsaturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing 1 to 2 oxygen atom(s) and 1 to 3 nitrogen atom(s), for example, oxazolyl, isoxazolyl, oxadiazolyl (e.g., 1,2, 4-oxadiazolyl, 1, 3, 4-oxadiazolyl, 1,2, 5-oxadiazolyl, etc. ) , etc. ; saturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing 1 to 2 oxygen atom(s) and 1 to 3 nitrogen atom(s), for example, morpholinyl, sydnonyl, etc.; unsaturated condensed heterocyclic group containing 1 to 2 oxygen atom(s) and 1 to 3 nitrogen atom(s), for example, benzoxazolyl, benzoxadiazolyl, etc.; unsaturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing 1 to 2 sulfur atom(s) and 1 to 3 nitrogen atom(s), for example, thiazolyl, isothiazolyl, thiadiazolyl (e.g., 1,2, 3-thiadiazolyl, 1,2, 4-thiadiazolyl, 1, 3, 4-thiadiazolyl, 1,2, 5-thiadiazolyl, etc.), dihydrothiazinyl, etc.; saturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing 1 to 2 sulfur atom(s) and 1 to 3 nitrogen atom(s), for example, thiazolidinyl, etc.; unsaturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing 1 to 2 sulfur atom(s), for example, thienyl, dihydrodithiinyl, dihydrodithionyl, etc.; unsaturated condensed heterocyclic group containing 1 to 2 sulfur atom(s) and 1 to 3 nitrogen atom(s), for example, benzothiazolyl, benzothiadiazolyl, etc.; unsaturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing an oxygen atom, for example, furyl, etc.; saturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing an oxygen atom, for example, tetrahydrofuran, tetrahydropyran, etc.; unsaturated 3 to 8-membered (more preferably 5 or 6- membered) heteromonocyclic group containing an oxygen atom and 1 to 2 sulfur atom(s), for example, dihydrooxathiinyl, etc. ; unsaturated condensed heterocyclic group containing 1 to 2 sulfur atom(s), for example, benzothienyl, benzodithiinyl, etc.; unsaturated condensed heterocyclic group containing an oxygen atom and 1 to 2 sulfur atom(s), for example, benzoxathiinyl, etc.; and the like, m which the preferred one may be saturated 3 to 8- membered heteromonocyclic group containing 1 to 4 nitrogen atom(s), unsaturated 3 to 8-membered heteromonocyclic group containing 1 to 2 oxygen atom(s/ and 1 to 3 nitrogen atom(s) , unsaturated 3 to 8-membered heteromonocyclic group containing 1 to 4 nitrogen atom(s), and unsaturated 3 to 8-membered heteromonocyclic group containing 1 to 2 sulfur atom(s) and 1 to 3 nitrogen atom's), and the most preferred one may be piperazinyl, isoxazolyl, oxadiazolyl, thiadiazolyl, pyrazolyl, Diperidyl, oxazolyl and pyrimidyl. Suitable example of "suitable substituent (s) " in the term of "aroyl substituted with heterocyclic group which may have one or more suitable substituent(s) , in which aroyl may have one or more suitable substituent(s) ", can be referred to aforementioned "suitable substituent (s) ", in which the preferred one may be aryl which may have I to 3 higher alkoxy, aryl which may have 1 to 3 lower alkoxy, higher alkyl, heterocyclic group, aryl which may have 1 to 3 lower alkoxy(higher)alkoxy, aryl which may have higher alkenyloxy, heterocyclic group which may have aryl having lower alkoxy, cyclo (lower) alkyl which may have aryl, aryl which may have 1 to 3 lower alkyl, aryl which may have cyclo(lower)alkyl, aryl which may have higher alkenyloxy, aryl substituted with heterocyclic group which may have lower alkyl and oxo, cyclo(lower)alkyl which may have lower alkyl, aryl substituteα with aryl which may have 1 to 3 lower alkoxy, and aryl which may have heterocyclic group, and the more preferred one may be phenyl which may have 1 to 3 (C7-C 4)alkoxy, phenyl which may have 1 to 3 (C 3 -Cg)alkoxy, (C 7 -C- 1 ) alkyl, saturated 3 to 8-membered heteromonocyclic group containing 1 to nitrogen atom(s), phenyl which may have 1 to 3 (C-,- C 4 ) alkoxy (C7-C- 1 ) alkoxy, pnenyl whicn may nave (C7- C- ] Δ ) alkenyloxy, saturated 3 to 8-membered heteromonocyclic group containing 1 to 4 nitrogen atom;s) substituted with phenyi having (C 3 -Cg) alkoxy, cyclo (C 3 -Cg; lkyl which may have phenyl, phenyl which may have 1 to 3 (C3-C-) alkyl, phenyl which may have cyclo (C 3 -Cg) alkyl, phenyl which may have (C7-C2 ) alkenyloxy, phenyl substituted with heterocyclic group which may have ;c 3 -Cg) alkyl and oxo, cyclo (C 3 -Cg) alkyl which may have (C 3 -Cg) lkyi, phenyl substituted with phenyl which may have 1 to 3 (C - C ! alkoxy, and phenyl which may have 3 to 8-membered heteromonocyclic group containing 1 to 4 nitrogen atom(s/, and the most preferred one may be phenyl having octyloxy, phenyl having pentyloxy, phenyl having hexyloxy, heptyl, piperidyl, phenyl having isohexyloxy, phenyl naving heptyloxy, phenyl having methoxyheptyloxy, phenyl having methoxyoctyloxy, phenyl having 6-heptenyloxy, piperidyl substituted with phenyl having hexyloxy, cyclohe.xyl having phenyl, phenyl having hexyl, phenyl naving cyclohexyi, phenyl having 7-octenyloxy, phenyl substituted witn triazolyl having lower alkyl and oxc, cyclohexyi having pentyl, phenyl having methoxyoctyloxy, nonyl, phenyl substituted with phenyl having propoxy, and phenyl having piperidine. Suitable example of "suitable substituent (s) " in the term of "in which aroyl may have one or more suitable substituent (s) " may be halogen, in which the preferred one may be fluorc and chloro. Suitable example of "aroyl" in the term of "aroyl substituted with aryl having heterocyclic (higher) alkoxy, in which heterocyclic group may have one or more suitable substituent (s) " may include benzoyl, toluoyl, naphthoyl. anthrylcarbonyl and the like, in which the preferred one may be benzoyl. Suitable example of "heterocyclic" moiety in the term of "aroyl substituted with aryl having heterocyclic(higher)alkoxy, in which heterocyclic group may have one or more suitable substituent (s) " can be referred to the ones as exemplified before for "heterocyclic group" in the term of "aroyl substituted with heterocyclic group which may have one or more suitable substituent (s) ", in which the preferred one may be unsaturated 3 to 8- membered heteromonocyclic group containing 1 to 4 nitrogen atom(s) and saturated 3 to 8-membered heteromonocyclic group containing 1 to 2 oxygen atom(s) and 1 to 3 nitrogen atom(s), and the most preferred one may be triazolyl, tetrazolyl and morpholinyl. Suitable example of " (higher) alkoxy" moiety in the term of "aroyl substituted with aryl having heterocyclic(higher) alkoxy, in which heterocyclic group may have one or more suitable substituent (s) " can be referred to aforementioned "higher alkoxy", in which the preferred one may be (C7-C24)alkoxy, and the most preferred one may be octyloxy. Suitable example of "aryl" in the term of "aroyl substituted with aryl having heterocyclic (higher)alkoxy, in which heterocyclic group may have one or more suitable substituent (s) " can be referred to aforementioned "aryl", in which the preferred one may be phenyl. Suitable example of "suitabl "ubstituen (s) " in the term of "in which heterocyclic gr ^ p may have one or more suitable substituent (s) " may be lower alkyl, in which the preferred one may be methyl. Suitable example of "aroyl" in the term of "aroyl substituted with aryl having lower alkoxy(higher)alkoxy" may include benzoyl, toluoyl, naphthoyl, anthrylcarbonyl and the like, in which the preferred one may be benzoyl. Suitable example of "aryl" in the term of "aroyl substituted with aryl having lower alkoxy(higher)alkoxy" can be referred to aforementioned "aryl", in which the preferred one may be phenyl. Suitable example of "lower alkoxy(higher) alkoxy" in the term of "aroyl substituted with aryl having lower alkoxy(higher) alkoxy" may be methoxyheptyloxy, methoxyoctyloxy, methoxynonyloxy, methoxydecyloxy, ethoxyheptyloxy, ethoxyoctyloxy, ethoxynonyloxy, ethoxydecyloxy, ethoxyundecyloxy, propoxyundecyloxy, butoxydodecyloxy, pentyloxytridecyloxy, hexyloxytetradecyloxy, propoxyheptyloxy, propoxyoctyloxy, propoxynonyloxy, butoxydecyloxy, or the like, in which the preferred one may be (C^-Cg) alkoxy(C7-C )alkoxy, and the more preferred one may be methoxyoctyloxy. Suitable example of "aroyl" in the term of "aroyl substituted with aryl having lower alkenyl (lower) alkoxy" may include benzoyl, toluoyl, naphthoyl, anthrylcarbonyl and the like, in which the preferred one may be benzoyl. Suitable example of "aryl" in the term of "aroyl substituted with aryl having lower alkenyl (lower) alkoxy" can be referred to aforementioned "aryl", in which the preferred one may be phenyl. Suitable example of "lower alkenyl (lower) alkoxy" in the term of "aroyl substituted with aryl having lower alkenyl (lower) alkoxy" may be vinylmethoxy, vinylethoxy, vinylpropoxy, vinylbutoxy, vinylpentyloxy, vinylhexyloxy, 1- (or 2-)propenylmethoxy, 1- (or 2-)propenylethoxy, 1- (or 2-)propenylpropoxy, 1-(or 2-)propenylbutoxy, l-(or 2-)- propenylpentyloxy, l-(or 2-)propenylhexyloxy, l-(or 2- or 3-)butenylbutoxy, 1- (or 2- or 3-)butenylhexyloxy, l-(or 2- or 3- or 4-)pentenylpentyloxy, l-(or 2- or 3- or 4-)- pentenylhexyloxy, 1- (or 2- or 3- or 4- or 5-)- hexenylbutoxy, 1- (or 2- or 3- or 4- or 5-)hexenylhexyloxy, or the like, in which the preferred one may be ^-C ) alkenyl (C2~ Cg)alkoxy, and the more preferred one may be vinylhexyloxy. Suitable example of "aroyl substituted with 2 lower alkoxy" may include benzoyl substituted with 2 lower alkoxy and naphthoyl substituted with 2 lower alkoxy, in which the preferred one may be benzoyl substituted with 2 (C2~C ) alkoxy, and the most preferred one may be benzoyl substituted with 2 pentyloxy. Suitable example of "aroyl substituted with aryl having lower alkyl" may include benzoyl substituted with phenyl having lower alkyl, benzoyl substituted with naphthyl having lower alkyl, naphthoyl substituted with phenyl having lower alkyl, naphthoyl substituted with naphthyl having lower alkyl, and the like, in which the preferred one may be benzoyl substituted with phenyl having (C ~Cg)alkyl, and the most preferred one may be benzoyl substituted with phenyl having hexyl and benzoyl substituted with phenyl having pentyl. Suitable example of "aroyl substituted with aryl having higher alkyl" may include benzoyl substituted with phenyl having higher alkyl, benzoyl substituted with naphthyl having higher alkyl, naphthoyl substituted with phenyl having higher alkyl, naphthoyl substituted with naphthyl having higher alkyl, and the like, in which the preferred one may be benzoyl substituted with phenyl having (C7-C 4) alkyl, and the most preferred one may be benzoyl substituted with phenyl having heptyl. Suitable example of "aryloxy" moiety in the term of "aryloxy(lower)alkanoyl which may have one or more suitable substituent (s) " may include phenoxy, mesityloxy, tolyloxy, naphthyloxy, anthryloxy, and the like, in which the preferred one may be phenoxy. Suitable example of "lower alkanoyl" moiety in the term of "aryloxy(lower) alkanoyl which may have one or more suitable substituent (s) " can be referred to aforementioned "lower alkanoyl", m which the preferred one may be formyl, acetyl, 2,2- dimethylacetyl, propionyl, butyryl, isobutyryl and pentanoyl, hexanoyl, and the more preferred one may be (C2~C ) alkanoyl, and the much more preferred one may be formyl, acetyl, propionyl and 2,2-dιmethylacetyl. Suitable example of "suitable substituent (s) " in the term of "aryloxy(lower) alkanoyl which may have one or more suitable substituent (s) " can be referred to aforementioned "suitable substituent (s) ", in which the preferred one may be (C7-C24) alkoxy, and the more preferred one may be octyloxy. Suitable example of "ar(lower)alkoxy" moiety in the term of "ar (lower)alkoxy(lower)alkanoyl which may have one or more suitable substituent (s) " may include phenyl (lower)alkoxy [e.g., phenylmethoxy, (1- or 2-)- phenylethoxy, phenylpropoxy, 2-phenyl-l-methylpropoxy, 3- phenyl-2,2-dimethylpropoxy, (1- or 2- or 3- or 4-)phenylbutoxy, (1- or 2- or 3- or 4- or 5-)phenylpentyloxy, (1- or 2- or 3- or 4- or 5- or 6- phenylhexyloxy, etc.], naphthyl (lower)alkoxy [e.g. naphthylmethoxy, (1- or 2-)napthylethoxy, 1-naphthylpropoxy, 2-naphthyl-l-methylpropoxy, 3-naphthyl- 2,2-dimetylpropoxy, (1- or 2- or 3- or 4-)naphthylbutoxy, (1- or 2- or 3- or 4- or 5-)naphthylpentyloxy, (1- or 2- or 3- or 4- or 5- or 6-)naphthylhexyloxy, etc.], and the like, in which the preferred one may be naphthyl (C -C4)alkoxy, and the more preferred one may be naphthylmethoxy. Suitable example of " (lower) alkanoyl" moiety in the term of "ar(lower)alkoxy(lower)alkanoyl which may have one or more suitable substituent (s) " can be referred to aforementioned "lower alkanoyl", in which the preferred one may be (C2-C )alkanoyl, and the more preferred one may be formyl. Suitable example of "suitable substituent(s) " in the term of "ar(lower) alkoxy(lower) alkanoyl which may have one or more suitable substituent (s) " can be referred to aforementioned "suitable substituent(s) ", in which the preferred one may be lower alkoxy, higher alkoxy, lower alkyl and higher alkyl, and the more preferred one may be higher alkoxy, and the much more preferred one may be (C7-C24)alkoxy, and the most preferred one may be heptyloxy. Suitable example of "arylamino" moiety in the term of "arylamino (lower) alkanoyl which may have one or more suitable substituent(s) " may include phenylamino, mesitylamino, tolylamino, naphthylamino, anthrylamino and the like, in which the preferred one may be phenylamino and naphthylamino. Suitable example of "lower alkanoyl" moiety in the term of "arylamino (lower)alkanoyl which may have one or more suitable substituent(s) " can be referred to aforementioned "lower alkanoyl", in which the preferred one may be (C2-C )alkanoyl, and the more preferred one may be formyl. Suitable example of "suitable substituent (s) " in the term of "arylamino(lower) alkanoyl which may have one or more suitable substituent (s) " can be referred to aforementioned "suitable substituent (s) ", in which the preferred one may be lower alkoxy, higher alkoxy, lower alkyl, higher alkyl, aryl which may have 1 to 3 lower alkoxy and aryl which may have 1 to 3 higher alkoxy, and the more preferred one may be (C7-C24) alkoxy, and phenyl which may have 1 to 3 (C7-C24)alkoxy, and the most preferred one may be heptyloxy and phenyl which may have heptyloxy. Suitable example of "lower alkanoyl" in the term of "lower alkanoyl substituted with pyrazolyl which has lower alkyl and aryl having higher alkoxy" can be referred to aforementioned "lower alkanoyl", in which the preferred one may be (C2-C4)alkanoyl, and the most preferred one may be formyl. Suitable example of "lower alkyl" in the term of "lower alkanoyl substituted with pyrazolyl which has lower alkyl and aryl having higher alkoxy" can be referred to aforementioned "lower alkyl", in which the preferred one may be (C2-C )alkyl, and the most preferred one may be methyl. Suitable example of "aryl" in the term of "lower alkanoyl substituted with pyrazolyl which has lower alkyl and aryl having higher alkoxy" can be referred to aforementioned "aryl", in which the preferred one may be phenyl. Suitable example of "higher alkoxy" in the term of "lower alkanoyl substituted with pyrazolyl which has lower alkyl and aryl having higher alkoxy" can be referred to aforementioned "higher alkoxy", in which the preferred one may be (C 7 -C24) alkoxy, and the most preferred one may be octyloxy. Suitable example of "lower alkoxy(higher)alkanoyl" in the term of "lower alkoxy(higher)alkanoyl, in which higher alkanoyl may have one or more suitable substituent (s) " may be (C2-C )alkoxy(C7-C20) lkanoyl, in which the preferred one may be methoxyoctadecanoyl. Suitable example of "suitable substituent (s) " in the term of "lower alkoxy(higher)alkanoyl, in which higher alkanoyl may have one or more suitable substituent (s) " may be amino and aforementioned "protected amino", in which the preferred one may be amino and ar(lower)alkoxycarbonylamino, and the most preferred one may be amino and benzyloxycarbonylamino. Suitable example of "aroyl" in the term of "aroyl substituted with aryl having heterocyclicoxy, in which heterocyclicoxy may have one or more suitable substituent (s) " can be referred to aforementioned "aroyl", in which the preferred one may be benzoyl. Suitable example of "aryl" in the term of "aroyl substituted with aryl having heterocyclicoxy, in which heterocyclicoxy may have one or more suitable substituent (s) " can be referred to aforementioned "aryl", in which the preferred one may be phenyl. Suitable example of "heterocyclic" moiety in the term of "aroyl substituted with aryl having heterocyclicoxy, in which heterocyclicoxy may have one or more suitable substituent (s) " can be referred to aforementioned "heterocyclic" moiety, in which the preferred one may be unsaturated 3 to 8-membered heteromonocyclic group containing 1 to 4 nitrogen atom(s), and the most preferred one may be pyridazinyl. Suitable example of "suitable substituent (s) " in the term of "aroyl substituted with aryl having heterocyclicoxy, in which heterocyclicoxy may have one or more suitable substituent(s) " may be aryl, in which the preferred one may be phenyl. Suitable example of "aroyl' ! in the term of "aroyl substituted with cycle (lower) alkyl having lower alkyl" car. be referred to aforementioned "aroyl", in which the preferred one may be benzoyl. Suitable example of "cyclo (lower) alkyl" in the term of "aroyl substituted with cyclo (lower) alkyl having lower alkyl" can be referred to aforementioned "cyclo (lower) alkyl", in which the preferred one may be cyclohexyi . Suitable example of "lower alkyl" in the term of "aroyl substituted with cyclo (lower) alkyl having lower alkyl" can be referred to aforementioned "lower alkyl", in which the preferred one may be pentyl. Suitable example of "higher alkyl" in the term of "indolylcarbonyi having higher alkyl" can be referred to aforementioned "higher alkyl", in which the preferred one may be decyl. Suitable example of "lower alkyl" in the term of "naphthoyl having lower alkyl" can be referred to aforementioned "lower alkyl", in which the preferred one may be hexyl. Suitable example of "higher alkyl" in the term of "naphthoyl having higher alkyl" can be referred to aforementioned "higher alkyl", m which the preferred one may be heptyl . Suitable example of "lower alkoxy(higher) alkoxy" in the term of "naphthoyl having lower alkoxy (higher) alkoxy" may be (C-* -C Δ _ ) alkoxy(C7-C 1 4) alkoxy, in which the preferred one may be methoxyoctyloxy. Suitable example of "aroyl" in the term of "aroyl substituted with aryl having lower alkoxy(lower) alkoxy(higher) alkoxy", "aroyl substituted with aryl having lower alkoxy(lower)alkoxy", "aroyl substituted with aryl which has aryl having lower alkoxy", "aroyl substituted with aryl which has aryl having lower alkoxy(lower)alkoxy", "aroyl substituted with aryl having heterocyclicoxy(higher) alkoxy", "aroyl substitued with aryl having aryloxy(lower)alkoxy" and "aroyl substituted with aryl having heterocycliccarbonyl (higher) alkoxy" can be referred to aforementioned "aroyl", in which the preferred one may be benzoyl. Suitable example of "aryl" in abovementioned terms can be referred to aforementioned "aryl", in which the preferred one may be phenyl. Suitable example of "lower alkoxy(lower) alkoxy- (higher)alkoxy" in the term of "aroyl substituted with aryl having lower alkoxy(lower) alkoxy(higher) alkoxy" may be (C2~C 4 ) alkoxy(C ~C 4 ) alkoxy(C7-C- 1 4) alkoxy, in which the preferred one may be ethoxyethoxyoctyloxy. Suitable example of "lower alkoxy(lower)alkoxy" in the term of "aroyl substituted with aryl having lower alkoxy(lower)alkoxy" may be (C -C4)alkoxy(C 3 -Cg) alkoxy, in which the preferred one may be propoxyhexyloxy. Suitable example of "lower alkoxy" in the term of "aroyl substituted with aryl which has phenyl having lower alkoxy" may be (C 3 -Cg)alkoxy, in which the preferred one may be butoxy. Suitable example of "lower alkoxy(lower)alkoxy" in the term of "aroyl substituted with aryl which has phenyl having lower alkoxy(lower) alkoxy" may be (C -C4) alkoxy- (C 3 ~Cg)alkoxy, in which the preferred one may be methoxypentyloxy and methoxyhexyloxy. Suitable example cf "heterocyclic" moiety in the term of "aroyl substituted with aryl having heterocyclicoxy(higher)alkoxy" can be referred to aforementioned "heterocyclic" moiety, in which the preferred one may be saturated 3 to 8-membered heteromonocyclic group containing an oxygen atom, and the most preferred one may be tetrahydropyranyl. Suitable example of "higher alkoxy" moiety in the term of "aroyl substituted with aryl having heterocyclicoxy(higher) alkoxy" may be ;c--C 1 j ) aikcxy, in which the preferred one may be octyloxy. Suitable example of "aryloxy(lower)alkoxy" in the term of "aroyl substituted with aryl having aryloxy(lower)alkoxy" may be phenoxy(C -C 8 )alkoxy, in which the preferred one may be phenoxypentyloxy. Suitable example of "heterocyclic" moiety in the term of "aroyl substituted with aryl having heterocycliccarbonyl (higher)alkoxy" can be referred to aforementioned "heterocyclic" moiety, in which the preferred one may be saturated 3 to 8-membered heteromonocyclic group containing 1 to 4 nitrogen atom(s), and the most preferred one may be piperidyl. Suitable example of "higher alkoxy" moiety in the term of "aroyl substituted with aryl having heterocycliccarbonyl (higher)alkoxy" can be referred to aforementioned "higher alkoxy", in which the preferred one may be (C 7 -C 1 4)alkoxy, and the most preferred one may be heptyloxy. Suitable example of "lower alkanoyl" in the term of "lower alkanoyl substituted with oxazolyl which has aryl having higher alkoxy" can be referred to aforementioned "lower alkanoyl", in which the preferred one may be (C-i-C4) alkanoyl, and the most preferred one may be formyl. Suitable example of "aryl" in the term of "lower alkanoyl substituted with oxazolyl which has aryl having higher alkoxy" can be referred to aforementioned "aryl", in which the preferred one may he phenyl. Suitable example of "higher alkoxy" in the term of "lower alkanoyl substituted with oxazolyl which has aryl having higher alkoxy" can be referred to aforementioned "higher alkoxy", in which the preferred one may be (C -C24)alkoxy, and the most preferred one may be octyloxy. Suitable example of "lower alkanoyl" in the term of "lower alkanoyl substituted with furyl which has aryl substituted with aryl having lower alkoxy" can be referred to aforementioned "lower alkanoyl", in which the preferred one may be (C -C4)alkanoyl, and the most preferred one may be formyl. Suitable example of "aryl" in the term of "lower alkanoyl substituted with furyl which has aryl substituted with aryl having lower alkoxy" can be referred to aforementioned "aryl", in which the preferred one may be phenyl. Suitable example of "lower alkoxy" in the term of "lower alkanoyl substituted with furyl which has aryl substituted with aryl having lower alkoxy" can be referred to aforementioned "lower alkoxy", in which the preferred one may be (C2-C )alkoxy, and the most preferred one may be butoxy. Suitable example of "lower alkanoyl" in the term of "lower alkanoyl substituted with triazolyl which has oxo and aryl having higher alkyl" can be referred to aforementioned "lower alkanoyl". in which the preferred one may be (d -C^ ) alkanoyl, and the most preferred one may be formyl. Suitable example of "higher alkyl" in the term of "lower alkanoyl substituted with triazolyl which has oxc and aryl having higher alkyl" can be referred to aforementioned "higher alkyl", in which the preferred one may be (C7-C 4) alkyl, and the most preferred one may be octyl. Suitable example of "aryl" in the term of "lower alkanoyl substituted with triazolyl which has oxo and ary2 having higher alkyl" can be referred to aforementioned "aryl", in which the preferred one may be phenyl. Suitable example of "higher alkanoyl" in the term cf "higher alkanoyl having hydroxy" can be referred to aforementioned "higher alkanoyl", in which the preferred cne may be (C7-C20) alkanoyl, and the most preferred one may be hexadecanoyl. Suitable example of "higher alkanoyl" in the term of "higher alkanoyl having ar (lower) lkyl and hydroxy" can be referred to aforementioned "higher alkanoyl", in which the preferred one may be (C7-C20) lkanoyl, and the most preferred one may be hexadecanoyl. Suitable example of "ar (lower) alkyl" in the term of "higher alkanoyl having ar (lower) alkyl and hydroxy" can be referred to aforementioned "ar (lower) alkyl", in which the preferred one may be phenyl (C-^ - ^ ) alkyl, and the most preferred one may be benzyl. Suitable example of " (C 2 -Cg) alkanoyl" in the terms of " (C 2 -Cg) alkanoyl substituted with aryl having higher alkoxy, in which (C 2 ~Cg) alkanoyl may have amino or protected amino" may include acetyl, propanoyl, butanoyl. pentanoyl, hexanoyl, and the like, in which the preferred one may be acetyl and propanoyl. Suitable example of "aryl" in the term of " (C 2 ~ Cg) alkanoyl substituted with aryl having higher alkoxy, in which (C 2 -Cg) alkanoyl may have amino or protected amino" can be referred to aforementioned "aryl", in which the preferred one may be phenyl. Suitable example of "higher alkoxy" in the term of " (C2~Cg) alkanoyl substituted with aryl having higher alkoxy, in which (C2 _ C )alkanoyl may have amino or protected amino" can be referred to aforementioned "higher alkoxy", in which the preferred one may be (C -C2 )alkoxy, and the most preferred one may be octyloxy. Suitable example of "protected amino" in the term of " (C2~Cg)alkanoyl substituted with aryl having higher alkoxy, in which (C2~C )alkanoyl may have amino or protected amino" can be referred to aforementioned "protected amino", in which the preferred one may be ar(lower)alkoxycarbonylamino, and the most preferred one may be benzyloxycarbonylamino. The process for preparing the object polypeptide compound [I] or a salt thereof of the present invention are explained in detail in the following. Process 1 The object polypeptide compound [I] or a salt thereof can be prepared by reacting the compound [II] or its reactive derivative at the amino group or a salt thereof with the compound [III] or its reactive derivative at the carboxy group or a salt thereof. Suitable reactive derivative at the carboxy group of the compound [III] may include an acid halide, an acid anhydride, an activated amide, an activated ester, and the like. Suitable examples of the reactive derivatives may be an acid chloride; an acid azide; a mixed acid anhydride with an acid such as substituted phosphoric acid [e.g., dialkylphosphoric acid, phenylphosphoric acid, diphenylphosphoric acid, dibenzylphosphoric acid, halogenated phosphoric acid, etc.], dialkylphosphorous acid, sulfurous acid, thiosulfuric acid, sulfuric acid, sulfonic acid [e.g., methanesulfonic acid, etc.], aliphatic carboxylic acid [e.g., acetic acid, propionic acid, butyric acid, isobutyric acid, pivaric acid, pentanoic acid, isopentanoic acid, 2-ethylbutyric acid, trichloroacetic acid, etc.]; or aromatic carboxylic acid [e.g., benzoic acid, etc.]; a symmetrical acid anhydride; an activated amide with imidazole, 4-substituted i idazole, dimethylpyrazole, triazole, tetrazole or 1- hydroxy-lH-benzotriazole; or an activated ester [e.g., cyanomethyl ester, methoxymethyl ester, dimethyliminomethyl [ (CH 3 )2N=CH-] ester, vinyl ester, propargyl ester, p-nitrophenyl ester, 2, -dinitrophenyl ester, trichlorophenyl ester, pentachlorophenyl ester, mesylphenyl ester, phenylazophenyl ester, phenyl thioester, p-nitrophenyl thioester, p-cresyl thioester, carboxymethyl thioester, pyranyl ester, pyridyl ester, piperidyl ester, 8-quinolyl thioester, etc.], or an ester with a N-hydroxy compound [e.g. N,N-dimethylhydroxylamine, l-hydroxy-2- (IH)-pyridone, N-hydroxysuccinimide, N-hydroxyphthalimide, 1-hydroxy-lH-benzotriazole, etc.], and the like. These reactive derivatives can optionally be selected from them according to the mind of the compound [III] to be used. Suitable salts of the compound [III] and its reactive derivative can be referred to the ones as exemplified for the object polypeptide compound [I] . The reaction is usually carried out in a conventional solvent such as water, alcohol [e.g., methanol, ethanol. etc.], acetone, dioxane, acetonitrile, chloroform, methylene chloride, ethylene chloride, tetrahydrofuran, ethyl acetate, N,N-dimethylformamide, pyridine or any other organic solvent which does not adversely influence the reaction. These conventional solvent may also be used in a mixture with water. In this reaction, when the compound [III] is used in a free acid form or its salt form, the reaction is preferably carried out in the presence of a conventional condensing agent such as N,N'-dicyclohexylcarbodiimide; N-cyclohexyl-N'-morpholinoethy1carbodiimide; N-cyclohexyl-N'- (4-diethylamιnocyclohexyl)carbodiimide; N,N'-diethylcarbodiimide, N,N'-diisopropylcarbodiimide; N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide, N,N-carbonylbis- (2-methylimidazole) ; pentamethyleneketene-N-cyclohexylimine; diphenylketene-N-cyclohexylimine; ethoxyacetylene; l-alkoxy-2-chloroethylene; trialkyl phosphite; ethyl polyphosphate; isopropyl polyphosphate; phosphorus oxychloride (phosphoryl chloride) ; phosphorus trichloride; thionyl chloride; oxalyl chlorid--; lower alkyl haloformate [e.g., ethyl chloroformate, isopropyl chloroformate, etc.]; triphenylphosphine; 2-ethyl-7- hydroxybenzisoxazolium salt; 2-ethyl-5- (m-sulfophenyl) isoxazolium hydroxide intramolecular salt; 1- (p-chlorobenzenesulfonyloxy)-6- chloro-lH-benzotriazole; so-called Vilsmeier reagent prepared by the reaction of N,N-dimethylformamide with thionyl chloride, phosgene, trichloromethyl c hloroformate, phosphorous oxychloride, methanesulfonyl chloride, etc.; or the like. The reaction may also be carried out in the presence of an inorganic or organic base such as an alkali metal carbonate, alkali metal bicarbonate, tri (lower)alkylamine, pyridine, di (lower) alkylaminopyridine (e.g.. 4-dιmethylamιnopyrιdme, etc.), N- (lower) alkylmorpholme, N,N-dι (lower) alkylbenzylamme, or the like. The reaction temperature is not critical, and the reaction is usually carried out under cooling to warming. The starting compound [II] is a known compound. It can be prepared by fermentation and synthetic processes disclosed in EP 0462531 A2. A culture of Coleophoma sp. F-11899, which is used m said fermentation process, has been deposited with National Institute of Bioscience and Human-Technology Agency of Industrial Science and Technology (former name: Fermentation Research Institute Agency of Industrial Science and Technology) (1-3, Higashi 1-chome, Tsukuba- shi, IBARAKI 305, JAPAN) on October 26, 1989 under the number of FERM BP-2635. The compounds obtained by the above Process 1 can be isolated and purified by a conventional method such as pulverization, recrystallization, column-chromatography, high-performance liquid chromatography (HPLC) , reprecipitation, or the like. The compounds obtained by the above Process 1 may be obtained as its hydrate, and its hydrate is included with¬ in the scope of this invention. It is to be noted that each of the object compound (I) may include one or more stereoisomer such as optical isomer (s) and geometrical isomer (s) due to asymmetric carbon atom(s) and double bond(s) and all such isomers and mixture thereof are included withm the scope of this invention. Biological property of the polypeptide compound m of the present invention In order to show the usefulness of the polypeptide compound [I] of the present invention, the biological data of the representative compound is explained in the following. Test 1 (Antimicrobial activity) : In vitro antimicrobial activity of tne compound of Example 17 disclosed later was determined by the two-fold agar-plate dilution method as described below. Test Method One loopful of an overnight culture of each test microorganism in Sabouraud broth containing 2 Glucose (10 5 viable cells per ml) was streaked on yeast nitrogen base dextrose agar (YNBDA) containing graded concentrations of the object polypeptide compound [I], and the minimal inhibitory concentration (MIC) was expressed in terms of μg/ml after incubation at 30°C for 24 hours. Test Result From the test result, it is realized that the object polypeptide compound [I] of the present invention has an antimicrobial activity (especially, antifungal activity) . The pharmaceutical composition of the present invention can be used in the form of a pharmaceutical preparation, for example, in solid, semisolid or liquid from, which contains the object polypeptide compound (I) or a pharmaceutically acceptable salt thereof, as an active ingredient in admixture with an organic or inorganic carrier or excipient which is suitable for rectal; pulmonary (nasal or buccal inhalation) ; ocular; external (topical); oral administration; parenteral (including subcutaneous, intravenous and intramuscular) administrations; insufflation (including aerosols from metered dose inhalator) ; nebulizer; or dry powder inhalator. The active ingredient may be compounded, for example, with the usual non-toxic, pharmaceutically acceptable carriers in a solid form such as granules, tablets, dragees, pellets, troches, capsules, or suppositories; creams, ointments; aerosols; powders for insufflation; in a liquid form such as solutions, emulsions, or suspensions for injection; ingestion; eye drops; and any other form suitable for use. And, if necessary, there may be included in the above preparation auxiliary substance such aε stabilizing, thickening, wetting, emulsifying and coloring agents; perfumes or buffer; or any other commonly may be used as additives. The object polypeptide compound [I] or a pharmaceutically acceptable salt thereof is/are included in the pharmaceutical composition in an amount sufficient to produce the desired antimicrobial effect upon the process or condition of diseases. For applying the composition to human, it is preferable to apply it by intravenous, intramuscular, pulmonary, oral administration, or insufflation. While the dosage of therapeutically effective amount of the object polypeptide compound [I] varies from and also depends upon the age and condition of each individual patient to be treated, in the case of intravenous administration, a daily dose of 0.01-20 mg of the object polypeptide compound [I] per kg weight of human being in the case of intramuscular administration, a daily dose of 0.1-20 mg of the object polypeptide compound [I] per kg weight of human being, in case of oral administration, a daily dose of 0.5-50 mg of the object polypeptide compound [I] per kg weight of human being is generally given for treating or preventing infectious diseases. Especially in case of the treatment of prevention of Pneumocystis carinii infection, the followings are to be noted. For administration by inhalation, the compounds of the present invention are conveniently delivered in the form of an aerosol spray presentation from pressurized as powders which may be formulated and the powder compositions may be inhaled with the aid of an insufflation powder inhaler device. The preferred delivery system for inhalation is a metered dose inhalation aerosol, which may be formulated as a suspension or solution of compound in suitable propellants such as fluorocarbons or hydrocarbons. Because of desirability to directly treat lung and bronchi, aerosol administration is a preferred method of administration. Insufflation is also a desirable method, especially where infection may have spread to ears and other body cavities. Alternatively, parenteral administration may be employed using drip intravenous administration. The following Preparations and Examples are given for the purpose of illustrating the present invention in more detail. Preparation 1 To a suspension of 1- (4-Hydroxyphenyl) -4-tert- butoxycarbonylpiperazine (3 g) and potassium carbonate (0.82 g) in N,N-dimethylformamide (15 ml) was added octyl bromide (1.87 ml) . The mixture was stirred for 10 hours at 70°C. The reaction mixture was added to a mixture of water and ethyl acetate. The organic layer was taken, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel, and eluted with (hexane : ethyl acetate = 9:1) . The fractions containing the object compound were combined, and evaporated under reduced pressure to give 1- (4-n-Octyloxyphenyl) -4-tert- butoxycarbonylpiperazine (2.71 g) . IR (KBr) : 1687, 1513, 1241 cm "1 NMR (CDC1 3 , δ) : 0.88 (3H, t, J=6.2Hz), 1.2-1.4 (10H, m) , 1.48 (9H, s), 1.65-1.85 (2H, ) , 3.00 (4H, t, J=5.2Hz), 3.57 (4H, t, J=5.2Hz), 3.90 (2H, t, J=6.5Hz), 6.83 (2H, dd, J=6.4 and 2.1Hz), 6.89 (2H, dd, J=6.4 and 2.1Hz) Preparation 2 A solution of 1- (4-n-Octyloxyphenyl) -4-tert- butoxycarbonylpiperazine (2.61 g) in trifluoroacetic acid (20 ml) was stirred for 4 hours at ambient temperature. The reaction mixture was evaporated under reduced pressure, and to the residue was added a mixture of IN NaOH aqueous solution and ethyl acetate. The organic layer was taken, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give l-(4-n- OctyloxyphenyDpiperazine (0.86 g) . IR (KBr) : 2923, 1513, 1259, 831 cm "1 NMR (CDC1 3 , δ) : 0.88 (3H, t, J=6.4Hz), 1.2-1.53 (10H, m) , 1.65-1.85 (2H, m) , 3.03 (4H, s), 3.90 (2H, t, J=6.5Hz), 6.83 (2H, dd, J=6.4 and 2.9Hz), 6.90 (2H, dd, J=β.4 and 2.9Hz) APCI-MASS : m/z = 291 (M + +l) Preparation 3 To a suspension of 1- (4-n-Octyloxyphenyl)piperazine (1 g) and potassium carbonate (0.476 g) in N,N-dimethyl- formamide (1 ml) was added p-fluorobenzonitrile (0.347 g) , and stirred for 5 hours at 160°C. The reaction mixture was added to a mixture of water and ethyl acetate. The organic layer was taken, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 4-[4-(4-n- Octyloxyphenyl)piperazin-l-yl]benzonitrile (0.93 g) . IR (KBr) : 2848, 2217, 1604, 1511, 1241 cm "1 NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.8Hz), 1.2-1.53 (10H, m) , 1.65-1.85 (2H, m) , 3.20 (4H, t, J=5.4Hz), 3.48 (4H, t, J=5.4Hz), 3.91 (2H, t, J=6.5Hz), 6.8-7.0 (6H, m) , 7.52 (2H, d, J=8.9Hz) APCI-MASS : m/z = 3 - (M + +l) Preparation 4 A mixture of 2, -Dihydroxybenzaldehyde (5.52 g) , potassium carbonate (6.08 g) and octyl bromide (7.73 g) in acetonitrile (55 ml) was stirred for 16 hours at 60°C. The solvent of reaction mixture was removed under reduced pressure, and the residue was dissolved in ethyl acetate, and washed with water and brine. The separated organic layer was dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure. The residue was subjected to column chromatography on silica - el and eluted with (hexane : ethyl acetate = 9:1) give 2-Hydroxy-4- octyloxybenzaldehyde (6.73 g) . NMR (CDC1 3 , δ) : 0.89 (3H, t, J=8.8Hz), 1.2-1.5 (10H, m) , 1.8-2.0 (2H, m) , 4.0-4.2 (2H, m) , 6.42 (IH, s), 6.52 (IH, d, J=8.7Hz), 7.79 (IK, d, J=8.7Hz), 10.33 (IH, s) APCI-MASS : m/z = 257 (M + +l) The following compound was obtained according to a similar manner to that of Preparation 4. preparation 5 Methyl 3, 4-dipentyloxybenzoate NMR (CDC1 3 , δ) : 0.93 (6H, t, J=6.0 and 9.0Hz), 1.3- 2.0 (12H, m) , 3.88 (3H, s), 4.04 (4H, m) , 6.86(1H, d, J=8.4Hz), 7.53 (IH, d, J=2.0Hz), 7.63 (IH, dd, J=8.4 and 2.0Hz) APCI-MASS : m/z = 309 (M + +l) Preparation 6 A mixture of 4-bromo- '-pentylbiphenyl (5.04 g) , trimethylsilylacetylene (2.4 ml), tetrakis (triphenylphosphine)palladium (0.96 g) , triphenylphosphine (0.22 g) and cuprous iodide (95 mg) in piperidine (10 ml) was heated for an hour under atmospheric pressure of nitrogen at 90°C. The reaction mixture was poured into a mixture of cold water and ethyl acetate, and adjusted to about pH 1 with 6N hydrochloric acid. The separated organic layer was washed with water and brine, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give crude 2- [4- (4- pentylphenyl)phenyl] -1-trimethylsilylacetylene, which was used for the next reaction without further purification. Crude mixture was dissolved in a mixture of dichloromethane (10 ml) and methanol (10 ml), and to the solution was added potassium carbonate (2.75 g) at 0°C. The mixture was allowed to warm to ambient temperature, and stirred for another 2 hours. The reaction mixture was poured into a mixture of cold water and ethyl acetate, and the resultant precipitate was filtered off. The filtrate was adjusted to about pH 7 with IN hydrochloric acid, and washed with brine, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give a crude powder, which was subjected to column chromatography on silica gel (300 ml), and eluted with a mixture of (n-hexane : ethyl acetate = 99:1 - 97:3, V/V) to give 4- (4- Pentylphenyl)phenylacetylene (2.09g) . IR (Nujol) : 3274, 1490 cm -1 NMR (CDC1 3 , δ) : 0.90 (3H, t, J=6.4Hz), 1.30-1.50 (4H, m) , 1.50-1.80 (2H, m) , 2 . 64 (2H, t, J=7.6Hz), 7.20-7.30 (2H, m) , 7.45-7.60 (6H, ) APCI-MASS : m/z = 281 (M + +l + MeOH) The following compound was obtained according to a similar manner to that of Preparation 6. Preparation 7 6-Heptyloxynaphthalen-2-yl-acetylene NMR (CDCI3, δ) : 0.90 (3H, t, J=6.5Hz), 1.20-1.60 (8H, m) , 1.70-1.90 (2H, ) , 3.10 (IH, s), 4.07 (2H, t, J=6.5Hz), 7.08 (IH, d, J=2.5Hz), 7.15 (IH, dd, J=2.5 and 8.9Hz), 7.47 (IH, dd, J=l .6 and 8.5Hz), 7.64 (IH, d, J=7.3Hz), 7.68 (IH, d, J=8.5Hz), 7.94 (IH, d, J=1.6Hz) APCI-MASS : m/z = 267 (M + +l) Prepa ation 8 To a solution of 4- (4-Pentylphenyl)phenylacetylene (2.09 g) in tetrahydrofuran (30 ml) was added dropwise a solution of lithium diisobutylamide in a mixture of tetrahydrofuran and n-hexane (1.60 M, 5.6 ml) at -75°C, and the resultant mixture was stirred for an hour at -78°C. To the mixture was added methyl chloroformate (0.72 ml), and the reaction mixture was allowed to warm to ambient temperature. The solution was diluted with ethyl acetate, and washed in turn with water and brine, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give a crude product, which was subjected to column chromatography on silica gel (150 ml), and eluted with a mixture of (n-hexane : ethyl acetate = 100:0 - 9:1, V/V) to give Methyl 3- [4- (4- pentylphenyl)phenyl]propionate (2.20 g) . IR (Nujol) : 2225, 1712 cm -1 NMR (CDC1 3 , δ) : 0.90 (3H, t, J=6.5Hz), 1.25-1.50 (4H, m) , 1.52-1.80 (2H, π) , 2.64 (2H, t, J=7.6Hz), 3.85 (3H, s), 7.20-7.35 (2H, m) , 7.40- 7.70 (6H, m) APCI-MASS : m/z = 307 (M + -*-l) The following compound was obtained according to a similar manner to that of Preparation 8. Preparation 9 Methyl 3- (6-heptyloxynaphthalen-2-yl)propionate IR (Nujol) : 2219, 1704, 1621 cm "1 NMR (CDCI 3 , δ) : 0.90 (3H, t, J=6.5Hz), 1.20-1.60 (8H, m) , 1.70-2.00 (2H, m) , 3.86 (3H, s) , 4.08 (2H, t, J=6.5Hz), 7.10 (IH, d, J=2.5Hz), 7.17 (IH, dd, J=2.5 and 8.9Hz), 7.52 (IH, dd, J=1.6 and 8.5Hz), 7.68 (IH, d, J=7.3Hz), 7.72 (IH, d, J=8.5Hz), 8.06 (IH, d, J=1.6Hz) APCI-MASS : m/z = 325 (M + +l) Preparation 10 A mixture of 4-bromo- '-pentyl^iphenyl (5.0 g) , methyl acrylate (2.2 ml), palladium acetate (0.11 g) and tris (o-tolyl)phosphine (0.60 g) in triethylamine (16 ml) was refluxed for 15 hours under nitrogen atmosphere. The reaction mixture was poured into a mixture of cold water and ethyl acetate, and adjusted to about pH 1.5 with 6N hydrochloric acid. The separated organic layer was washed in turn with water and brine, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give a crude powder, which was subjected to column chromatography on silica gel (200 ml), and eluted with a mixture of (n- hexane : ethyl acetate = 100:0 - 94:6, V/V) to give Methyl 3- [4- (4-pentylphenyl)phenyl] acrylate (4.48 g) . IR (Nujol) : 1718, 1637 cm "1 NMR (CDC1 3 , δ) : 0.91 (3H, t, J=6.7Hz), 1.20-1.50 (4H, ) , 1.50-1.80 (2H, m) , 2.65 (2H, t, J=7.4Hz), 3.82 (3H, s), 6.47 (IH, d, J=16.0Hz), 7.20-7.35 (2H, m) , 7.45-7.68 (6H, m) , 7.73 (IH, d, J=16.0Hz) APCI-MASS : m/z = 309 (M + +l) The following compounds (Preparations 11 to H) were obtained according to a similar manner to that of Preparation 10. Preparation 11 Methyl 3- (6-heptyloxynaphthalen-2-yl) acrylate IR (Nujol) : 1716, 1625, 1459 cm "1 NMR (CDC1 3 , δ) : 0.90 (3H, t, J=6.5Hz), 1.20-1.65 (8H, m) , 1.76-1.93 (2H, m) , 3.82 (3H, s), 4.07 (2H, t, J=6.5Hz), 6.49 (IH, d, J=16.0Hz), 7.05- 7.20 (2H, ), 7.55-7.90 (5H, m) APCI-MS : m/z = 327 (M + +l) 96/11210 - 52 - Preparation 12 Methyl 3- [4- (4-heptylphenyl)phenyl] acrylate NMR (CDC1 3 , δ) : 0.88 (3H, t, J=6.5Hz), 1.15-1.50 (8H, m) , 1.50-1.75 (2H, m) , 2.64 (2H, t, J=7.6Hz), 3.81 (3H, s) , 6.46 (IH, d, J=16.0Hz), 7.26 (2H, d, J=8.2Hz), 7.52 (2H, d, J=8.2Hz), 7.59 (6H, s), 7.73 (IH, d, J=16.0Hz) APCI-MASS : m/z = 337 (M + +l) Preparation 13 Methyl 3- [4- (4-pentyloxyphenyI)phenyl] acrylate NMR (CDCI3, δ) : 0.94 (3H, t, J=7.0Hz), 1.30-1.60 (4H, ) , 1.70-1.93 (2H, m) , 3.82 (3H, s), 4.00 (2H, t, J=6.7Hz), 6.45 (IH, d, J=16.0Hz), 6.90- 7.05 (2H, in) , 7.48-8.65 (6H, m) , 7.72 (IH, d, J=l6.0Hz) APCI-MASS : m/z = 325 (M + +l) Preparation 14 A mixture of 6-Heptyloxynaphthalen-2-carboxylic acid (1.00 g) and thionyl chloride (5 ml) was stirredn for 18 hours at ambient temparature, and concentrated under reduced pressure to give crude 6-heptyloxy-2-naphthoyl chloride. To a mixture of ethyl isonipecotinate (605 mg) , triethylamine (425 mg) and N,N-dimethylaminopyridine (10 mg) in dichloromethane (10 ml) was added crude 6- heptyloxy-2-naphthoyl chloride, and the mixture was stirred for 2 hours at ambient temperature, and diluted with dichloromethane. The mixture was washed with water, IN hydrochloric acid and brine, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and filtrate was evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel, and eluted with (n-hexane : ethyl acetate = 3:1) to give 4-Ethoxycarbonyl-l- (6-heptyloxy-2- naphthoyl)piperidine (1.20 g) . NMR (CDC1 3 , δ) : 0.90 (3H, t, J=6.6Hz), 1.2-2.0 (19H, m) , 2.5-2.7 (IH, ) , 3.0-3.2 (2H, m) , 4.1- 4.3 (4H, m) , 7.1-7.2 (2H, m) , 7.44 (IK, dd, J=8.4 and 1.7Hz), 7.72 (IH, d, J=3.9Hz), 7.77 (IH, d, J=3.9Hz), 7.82 (IH, s) APCI-MASS : m/z = 426 (M + +l) Prep ration 15 To a mixture of Methyl 3, 4-diaminobenzoate (1.91 g) and triethylamine (0.56 g) in N,N-dimethylformamide (20 ml) was added decanoyl chloride (2.31 g) , and the mixture was stirred for an hour at 0°C. The reaction mixture was diluted with ethyl acetate, and washed with water and brine. The separated organic layer was dried over magnesium sulfate. The magnesium sulfate was filtered off, and filtrate was evaporated under reduced pressure. The residue was dissolved in methanol (20 ml), and cone. sulfuric acid (0.05 ml) was added, and the mixture was stirred for 6 hours at 60°C. After cooling, the reaction mixture was evaporated under reduced pressure. The residue was diluted with ethyl acetate, and washed with water and brine. The separated organic layer was dried over magnesium sulfate. The magnesium sulfate was filtered off, and filtrate was evaporated under reduced pressure. Purification of the residue by column chromatography on silica gel eluted with (n-hexane : ethyl acetate = 3:1) gave 5-Methoxycarbonyl-2-nonylbenzimidazole (1.40 g) . IR (KBr pelet) : 2923, 1718, 1623, 1544, 1438, 1413, 1288, 1213, 1085, 750 cm "1 NMR (DMSO-dg, δ) : 0.84 (3H, t, J=6.7Hz), 1.1-1.4 (12K, m) , 1.7-1.9 (2H, m) , 2.83 (2H, t, J=7.4Hz), 7.56 (IH, d, J=8.4Hz), 7.78 (IH, d, J=8.4Hz), 8.07 (IH, s) APCI-MASS : m/z = 303 (M + +l) Preparation 16 To a mixture of dimethylmalonate (4 ml), 2-hydroxy-4- octyloxybenzaldehyde (2.50 g) and piperidine (0.1 ml) in methanol (10 ml) was added acetic acid (0.01 ml), and the mixture was stirred for 3 hours at 70°C. The solvents were removed under reduced pressure, and the residue was dissolved in ethyl acetate, and washed with 0.5N hydrochloric acid, water and brine, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and filtrate was evaporated under reduced pressure, and the precipitate was collected by filtration, and washed with n-hexane, and dried to give Methyl 7- octyloxycoumaπn-3-carboxylate (0.94 g) . NMR (DMSO-dg, δ) : 0.86 (3H, m) , 1.2-1.6 (10H, m) , 1.7-1.8 (2H, m) , 3.81 (3H, s) , 4.11 (2H, t, J=6.4Hz), 6.9-7.1 (2H, m) , 7.83 (IH, d, J=9.0Hz), 8.75 (IH, s) APCI-MASS : m/z = 333 (M + +l) Preparation 17 To a mixture of sodium hydride (423 mg) and 4- octylphenol (2.06 g) in tetrahydrofuran (16 ml) was added dropwise ethyl 2-chloroacetoacetate at ambient temperature. The mixture was stirred for 6 hours at 70°C under nitrogen atmosphere, and poured into saturated ammonium chloride aqueous solution. The solution was extracted with ethyl acetate, and the organic layer was washed with water and brine, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure. The residue was added to cone. H2SO4 (10 ml) at 0°C, and mixture was stirred for 10 minutes. The reaction mixture was poured into ice-water, and adjusted to pH 7.0 with IN NaOH aqueous solution, and extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure. The residue was subjected to column- chromatography on silica gel, and eluted with (hexane : ethyl acetate = 95:5). The fractions containing the object compound were combined, and evaporated under reduced pressure to give Ethyl 3-methyl 5- octylbenzo[b] furan-2-carboxylate (1.44 g) . IR (Neat) : 2925, 2854, 1712, 1596, 1463, 1292, 1149, 1089 cm "1 NMR (CDC1 3 , δ) : 0.88 (3H, t, J=6.7Hz), 1.2-1.5 (10H, m) , 1.44 (3H, t, J=7.1Hz), 1.6-1.8 (2H, m) , 2.58 (3H, s), 2.71 (2H, t, J=8.0Hz), 4.45 (2H, t, J=7.1Hz), 7.2-7.5 (3H, m) APCI-MASS : m/z = 317 (M + +l) Preparation 18 To a solution of Ethyl 3-amino-4-hydroxybenzoate (1.81 g) and triethylamine (1.53 ml) in dichloromethane (20 ml) was dropwise added decanoyl chloride (2.01 ml) at 0°C. The reaction mixture was stirred for 48 hours at ambient temperature, and washed with water, 0.5N hydrochloric acid, water and brine. The separated organic layer was dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure. To the residue dissolved in xylene (30 ml) was added p-tolune sulfonic acid monohydrate (0.5 g) , and the mixture was stirred for 4 hours at 130°C . Ethyl acetate was added to the mixture, and washed with water and brine. The separated organic layer was dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure. Purification of the residue by column chromatography on silica gel elluted with (n-hexane : ethyl acetate = 9:1, V/V) gave Ethyl 2-nonyl benzo [b]oxazole-6-carboxylate (2.36 g) . IR (KBr pelet) : 2914, 1722, 1621, 1575, 1470, 1429, 1365, 1290, 1203, 1151, 1115, 1081, 1022 cm "1 NMR (CDC1 3 , δ) : 0.88 (3H, t, J=6.7Hz), 1.2-1.4 (12H, m) , 1.42 (3H, t, J=7.2Hz), 1.90 (2H, m) , 2.95 (2H, t, J=7.4Hz), 4.40 (2H, q, J=7.0Hz), 7.50 (IH, d, J=8.5Hz), 8.06 (IH, d, J=8.5Hz), 8.37 (IH, s) APCI-MASS : m/z = 318 (M + +l) Preparation 19 A mixture of Methyl 3, 4-diaminobenzoate (1.84 g) and 4-hexyloxy benzaldehyde (2.30 g) in nitrobenzene (40 ml) was stirred for 48 hours at 145°C. After cooling, the mixture was evaporated under reduced pressure. Purification of the residue by column chromatography on silica gel eluted with (n-hexane : ethyl acetate = 2:1) gave 5-Methoxycarbonyl-2- (4-hexyloxyphenyl)benzimidazole (1.19 g) . NMR (CDCI3, δ) : 0.90 (3H, t, J=6.4Hz), 1.2-1.9 (8H, m) , 3.92 (3H, s) , 3.90-4.1 (2H, m) , 6.93 (2K, d, J=8.9Hz), 7.5-7.8 (IH, br) , 7.94 (IK, dd, J=8.5 and 1.5Hz), 8.03 (IH, d, J=8.9Hz), 8.2-8.4 (IH, br) APCI-MASS : m/z = 353 (M + +l) Preparation 20 A mixture of Methyl 3- [4- (4-pentylphenyl)phenyl]- acrylate (2.0 g) and 10% palladium on carbon (50o wet, 0.2 g) in tetrahydrofuran (20 ml) was stirred for 8 hours under atmospheric pressure of hydrogen at ambient temparature. The catalyst was filtered off, and the filtrate was evaporated under reduced pressure to give Methyl 3- [4- (4-pentylphenyl)phenyl]propionate (1.93 g) . NMR (CDC1 3 , δ) : 0.90 (3H, t, J=6.8Hz), 1.25-1.50 (4H, m) , 1.50-1.75 (2H, m) , 2.55-2.75 (4H, m) , 2.99 (2H, t, J=8.0Hz), 3.68 (3H, s), 7.10-7.30 (4H, m) , 7.40-7.60 (4H, m) APCI-MASS : m/z = 311 (M + +l) Preparation 21 A mixture of Methyl 3- [4- (4-pentyloxyphenyl)phenyl] - acrylate (2.70 g) and platinum oxide (0.41 g) in tetrahydrofuran (40 ml) was stirred for 8 hours under 3 atom of hydrogen at ambient temperature. The catalyst was filtered off, and the filtrate was evaporated under reduced pressure to give Methyl 3- [4- (4- pentyloxyphenyl)phenyl]propionate (2.70 g) . NMR (CDC1 3 , δ) : 0.94 (3H, t, J=7.0Hz), 1.28-1.60 (4H, m) , 1.60-1.95 (2H, m) , 2.55-2.78 (2H, ) , 2.98 (2H, t, J=7.8Hz), 3.98 (2H, t, J=6.5Hz), 6.85-7.05 (2H, ) , 7.05-7.30 (2H, m) , 7.40-7.55 (4H, m) APCI-MASS : m/z = 327 (M + -fl) The following compound was obtained according to a similar manner to that of Preparation 21. Preparation 22 Methyl 3- (6-heptyloxynaphthalen-2-yl) ropionate NMR (CDC1 , δ) : 0.90 (3H, t, J=6.5H: . 1.20-1.70 (8H, m) , 1.70-1.93 (2H, m) , 2.70 2H, t, J=7.7Hz), 3.07 (2H, t, J=7.7Hz), 3.67 (3H, s ) , 4.05 (2H, t, J=6.5Hz), 7.02-7.20 (2H, m) , 7.20- 7.38 (2H, m) , 7.55 (IH, s) , 7.66 (IH, dd, J=3.0 and 8.5Hz) APCI-MASS : m/z = 329 (M + +l) Preparation 23 To a mixture of Methyl 3- [4- (4-pentylphenyl)phenyl] - acrylate (0.41 g) in tetrahydrofuran (5 ml) was added 3N NaOH aqueous solution (1.3 ml), and the resultant mixture was heated to 85°C for 10 hours. The reaction mixture was poured into a mixture of cold water and ethyl acetate, and adjusted to about pH 2 with 6N hydrochloric acid. The separated organic layer was washed m turn with water and brine, and dried over magnesiuir sulfate. The magnesium sulfate was filtered off, and tne filtrate was evaporated under reduced pressure to give 3- [4- (4- Pentylphenyl)phenyl] crylic acid (0.41 g) . NMR (DMSO-dg, δ) : 0.87 (3H, t, J=^.5Hz), 1.15-1.46 (4H, ) , 1.48-1.70 (2H, m) , 2.61 (2H, t, J=7.4Hz), 6.56 (IH, d, J=16.0Hz), 7.29 (2H, d, J=8.2Hz), 7.60 (2H, d, J=4.0Hz), 7.66 (2H, d, J=4.0Hz), 7.68-7.85 (3H, m) APCI-MASS : m/z = 295 (M + +l) The following compounds (Preparations 24 to 3J were obtained according to a similar manner to that of Preparation 23. Preparation 24 3- [4- (4-Pentyloxyphenyl)phenyl]propιonιc acid IR (Nujol) : 1697, 1606, 1500 cm "1 NMR (CDC1 3 , δ) : 0.94 (3H, t, J=7.1Hz), 1.25-1.60 (4H, m) , 1.70-1.95 (2H, m) , 2.72 (2H, t, J=7.5Hz), 3.00 (2H, t, J=7.5Hz), 3.99 (2H, t, J=6.5Hz), 6.95 (2H, dd, J=2.1 and 6.7Hz), 7.25 (2H, d, J=8.2Hz), ^.40-7.60 (4H, m) APCI-MASS : m/z = 313 (M + -rl) Preparation 25 3- [4- (4-Heptylphenyl)phenyl]propιonιc acid NMR (CDC1 3 , δ) : 0.88 (3H, t, J=6.8Hz), 1.15-1.50 (8H, m) , 1.50-1.78 (2H, m) , 2.65 (2H, t, J=7.6Hz), 6.48 (IH, d, J=16.0Hz), 7.27 (2H, d, J=8.2Hz), 7.53 (2H, d, J=8.2Hz), 7.63 (4H, m) , 7.83 (IH, d, J=l6.0Hz) APCI-MASS : m/z = 323 (M + +l) Preparation 26 3- [ - ( -Pentylphenyl)phenyl]propionic acid NMR (CDC1 3 , δ) : 0.90 (3H, t, J=6.4Hz), 1.20-1.50 (4H, m) , 1.50-1.75 (2H, m) , 2 . 64 (2H, t, J=8.0Hz), 2.67 (2H, t, J=9.6Hz), 3.00 (2H, t, J=8.0Hz), 7.15-7.38 (4H, m) , 7.38-7.60 (4H, m) APCI-MASS : m/z = 297 (M + +l) Preparation 27 3- (6-Heptyloxynaphthalen-2-yl)propionic acid NMR (CDCI3, δ) : 0.90 (3H, t, J=6.5Hz), 1.20-1.65 (8H, m) , 1.75-2.00 (2H, m) , 2.75 (2H, t, J=7.7Hz), 3.09 (2H, t, J=7.7Hz), 4.06 (2H, t, J=6.5Hz), 7.05-7.15 (2H, m) , 7.15-7.35 (2H, m) , 7.50-7.73 (2H, m) APCI-MASS : m/z = 315 (M + +l) Preparation 23 3- (6-Heptyloxynaphthalen-2-yl) acrylic acid NMR (CDCI3, δ) : 0.90 (3H, t, J=6.5Hz), 1.15-1.60 (8H, m), 1.75-1.95 (2H, m) , 4.09 (2H, t, J=6.5Hz), 6.51 (IH, d, J=l6.0Hz), 7.09-7.30 (2H, m) , 7.65-8.00 (5H, m) Preparation 29 3- [4- (4-Pentylphenyl)phenyl]propionic acid NMR (CDC1 3 , δ) : 0.91 (3H, t, J=6.5Hz), 1.23-1.50 (4H, m) , 1.50-1.80 (2H, m) , 2.65 (2H, t, J=7.6Hz), 7.27 (2H, d, J=8.2Hz), 7.51 (2H, d, J=8.2Hz), 7.58-7.80 (4H, m) APCI-MASS : m/z = 325 (M + +l + MeOH) Preparation 30 3- (6-Heptyloxynaphthalen-2-yl)propionic acid IR (Nujol) : 2645, 2198, 1670, 1627 cm "1 NMR (DMSO-dg, δ) : 0.85 (3H, t, J=6.5Hz), 1.10-1.60 (8H, m) , 1.65-1.90 (2H, m) , 4.10 (2H, t, J=6.5Hz), 7.24 (IH, dd, J=2.4 and 8.9Hz), 7.39 (IH, d, J=2.5Hz), 7.55 (IH, dd, J=l .6 and 8.5Hz), 7.8-8.0 (2H, m) , 8.22 (IH, d, J=1.6Hz) APCI-MASS : m/z = 343 (M + +I + MeOH) Preparation 31 4- [5- (4-Pentyloxyphenyl) isoxazolyl-3-yl]benzoic acid IR (KBr) : 2939, 2867, 1681, 1614, 1429, 1255, 1178, 821 cm "1 NMR (DMSO-dg, δ) : 0.91 (3H, t, J=7.1Hz), 1.3-1.5 (4H, m) , 1.6-1.8 (2H, m) , 4.04 (2H, t, J=6.5Hz), 7.11 (2H, d, J=8.9Hz), 7.54 (IH, s) , 7.85 (2H, d, J=8.9Hz), 7.98 (2H, d, J=8.6Hz), 8.11 (2H, d, J=8.6Hz) APCI-MASS : m/z = 352 (M+H) + Preparation 32 To a solution of Ethyl 3-methyl-5-cctylbenzo [b] furan- 2-carboxylate (1.44 g) in ethanol (20 ml) was added 10% NaOH aqueous solution (2.2 ml), and stirred for 2 hours at ambient temperature, and evaporated under reduced pressure. The residue was adjusted to pH 3.0 with IN hydrochloric acid, and extracted with ethyl acetate. The organic layer was washed with brine, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 3-Methyl-5-octylbenzo [b] furan-2-carboxylic acid (1.00 g ) * IR (KBr pelet) : 2923, 1689, 1664, 1581, 1456, 1319, 1159, 933 cm "1 NMR (DMSO-dg, δ) : 0.85 (3H, t, J=6.7Hz), 1.2-1.5 (10H, m) , 1.5-1.8 (2H, m) , 2.49 (3H, s), 2.69 (2H, t, J=7.9Hz), 7.32 (IH, dd, J=8.5 and 1.7Hz), 7.52 (IH, d, J=8.5Hz), 7.54 (IH, d, J=1.7Hz), 13.2-13.5 (IH, br) APCI-MASS : m/z = 289 (M + +l) The following compounds (Preparations 33 to 3_9_) were obtained according to a similar manner to that of Preparation 32. Preparation 3 3, 4-Dipentyloxybenzoic acid NMR (DMSO-dg, δ) : 0.89 (6H, t, J=6.8Hz), 1.2-1.5 (8H, m) , 1.6-1.8 (4H, m) , 3.9-4.1 : . ' I, nl), 7.02 (IH, d, J=8.4Hz), 7.43 (IH, d, J=1.7Hz), 7.53 (IH, dd, J=8.4 and 1.7Hz) APCI-MASS : m/z = 295 (M + +l) Preparation 34 1- (6-Heptyloxy-2-naphthoyl)piperidine-4-carboxylic acid NMR (DMSO-dg, δ) : 0.88 (3H, t, J=6.7Hz), 1.2-2.0 (14H, m) , 2.5-2.6 (IH, m) , 2.9-3.2 (2H, br) , 3.25 (2H, s), 4.09 (2H, t, J=6.5Hz), 7.20 (IH, dd, J=8.9 and 2.4Hz), 7.36 (IH, d, J=2.3Hz), 7.43 (IH, dd, J=8.4 and 1.5Hz), 7.8-8.0 (3H, m) , 12.30 (IH, br) APCI-MASS : m/z = 398 (M++1) Preparation 35 7-Octyloxycoumarin-3-carboxylic acid IR (KBr) : 1748, 1625, 1558, 1467, 1430, 1386, 1360, 1257, 1217, 1120 cm "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.8Hz) , 1.2-1.5 (10H, m) , 1.6-1.8 (2H, m) , 4.11 (2H, t, J=6.4Hz), 6.9-7.1 (2H, m) , 7.82 (IH, d, J=8.9Hz), 8.72 (IH, s), 12.98 (IK, br) APCI-MASS : m/z = 319 (M + +l) Preparation 36 4- (4-Pentyloxyphenyl) cinnamic acid IR (Nujol) : 2923, 1675, 1500, 1290, 1223, 985, 821 cm "1 NMR (DMSO-dg, δ) : 0.90 (3H, t, J=7.0Hz), 1.3-1.5 (4H, m) , 1.6-1.8 (2H, m) , 4.01 (2H, t, J=6.5Hz), 6.54 (IH, d, J=16.0Hz), 7.02 (2H, d, J=8.8Hz), 7.5-7.8 (7H, m) APCI-MASS : m/z = 311 (M + +l) Preparation 37 2-Nonylbenzoxazole-6-carboxylic acid NMR (DMSO-dg, δ) : 0.84 (3H, t, J=6.7Hz), 1.2-1.5 (12H, m) , 1.7-1.9 (2H, m) , 2.96 (2H, t, J=7.4Hz), 7.76 (IH, d, J=8.4Hz), 7.98 (IH, d, J=8.4Hz), 8.19 (IH, s) APCI-MASS : m/z = 290 (M + +l) Preparation 38 2- (4-Hexyloxyphenyl)benzimidazole-5-carboxylic acid NMR (DMSO-dg, δ) : 0.8-1.0 (3H, m) , 1.3-1.6 (6H, ) , 1.7-1.8 (2H, m) , 4.06 (2H, t, J=6.4Hz), 7.12 (2H, d, J=8.8Hz), 7.6-7.9 (2H, m) , 8.1-8.2 (3H, m) , 13.00 (IH, br) APCI-MASS : m/z = 339 (M + +l) Preparation 39 2-Nonylbenzimidazole-5-carboxylic acid NMR (DMSO-dg, δ) : 0.85 (3H, t, J=6.7Hz), 1.1-1.4 (12H, ) , 2.7-2.9 (2H, m) , 2.96 (2H, t, J=7.6Hz), 3.6-5.2 (IH, br) , 7.66 (IH, d, J=8.4Hz), 7.90 (IH, d, J=8.4Hz), 8.15 (IH, s) APCI-MASS : m/z = 289 (M + +l) Preparation 40 A solution of 4- [4- (4-Octyloxyphenyl)piperazin-1- yl]benzonitrile (0.5 g) in 20r H2SO aσueous solution (30 ml) and acetic acid (20 ml) was refluxed for 9 hours. The reaction mixture was pulverized with water. The precipitate was collected by filtration, and added to a mixture of water, tetrahydrofuran and ethyl acetate, and adjusted to pH 2.5 with IN NaOH aqueous solution. The organic layer was taken, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 4- [4- (4- Octyloxyphenyl)piperazin-l-yl]benzoic acid (388 mg) . IR (KBr) : 2929, 1664, 1600, 1510, 1240 cm "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.6Hz), 1.2-1.5 (10H, ) , 1.5-1.8 (2H, ) , 3.13 (4H, t, J=5.3Hz), 3.44 (4H, t, J=5.3Hz), 3.88 (2H, t, J=6.5Hz), 6.83 (2H, d, J=9.2Hz), 6.94 (2H, d, J=9.2Hz), 7.02 (2H, d, J=9.0Hz), 7.79 (2H, d, J=9.0Hz) APCI-MASS : m/z = 411 (M + +l) Preparation 41 To a suspension of sodium hydride (60 1 : suspension in mineral oil) (0.296 g) in N,N-dimethylformamide (14 ml) was added 1, 2, -triazole (0.511 g) and 4-[4-(8- bromooctyloxy)phenyl]benzoic acid (1 g) , and was stirred for 5 hours at 120°C. The reaction mixture was added to a mixture of water and ethyl acetate, and adjusted to pH 2.5 with cone, hydrochloric acid. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 4- [ - [8- (1, 2, 4-Triazol-l- yl) octyloxy]phenyl]benzoic acid (0.81 g) . IR (KBr) : 2940, 1689, 1604, 1297, 1189 cm "1 NMR (DMSO-d 6 , δ) : 1.1-1.53 (8H, m) , 1.6-1.9 (4H, ) , 4.00 (2H, t, J=6.3Hz), 4.16 (2H, t, J=7.0Hz), 7.03 (2H, d, J=8.7Hz), 7.67 (2H, d, J=8.7H∑), 7.75 (2H, d, J=8.4Hz), 7.95 (IH, s), 7.99 (2H, d, J=8.4Hz), 8.51 (IH, s), 12.9 (IH, s) APCI-MASS : m/z = 394 (M + ÷l) Preparation 42 A mixture of 2-Carbamoyl-5-methoxybenzo[b]thiophene (2.0 g) , acetic acid (5 ml) and 48% hydrobromic acid (20 ml) was stirred for 16 hours at 110°C, and the mixture was poured into the ice-water. The resulting precipitate was collected by filtration, and dried to give 5- Hydroxybenzo [b] thiophene-2-carboxylic acid (1.66 g) . NMR (DMSO-dg, δ) : 7.03 (IH, dd, J=8.8 and 0.6Hz), 7.31 (IH, d, J=0.6Hz), 7.81 (IH, d, J=8.8Hz), 7.96 (IH, s), 9.64 (IH, s), 13.32 (IH, s) APCI-MASS : m/z = 195 (M + +l) Preparation 43 A solution of (S) -2-Tert-butoxycarbonyl-l,2, 3, 4- tetrahydro-7-hydroxyisoquinoline-3-carboxylic acid (1 g) in a mixture of 10% NaOH aqueous solution (2.73 ml) and dimethylsulfoxide (11 ml) was stirred for half an hour at 80°C. Then, octyl bromide (0.589 ml) was added thereto, and stirred for 4 hours at 60°C. The reaction mixture was added to a mixture of water and ethyl acetate, and adju ^ ~d to pH 2.5 with cone, hydrochloric acid. The organic layer was taken, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give (S)-2-Tert- butoxycarbonyl-1, 2, 3, 4-tetrahydro-7-octyloxyisoquinoline- 3-carboxylic acid (1.30 g) . IR (Neat) : 2929, 1743, 1704, 1164 cm "1 NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.1Hz), 1.1-1.6 (10H, m) , 1.41 + 1.51 (9H, s, cis + trans), 1.75 (2H, quint, J=6.5Hz), 3.10 (2H, m) , 3.90 (2H, t, J=3.9Hz), 4.42 (IH, d, J=16.8Hz), 4.65 (IH, d, J=I6.8Hz), 4.74 + 5.09 (IH, , cis + trans), 6.5-6.8 (2H, m) , 7.03 (IH, d, J=8.3Hz) APCI-MASS : m/z = 306 (M + +l-Boc) The following compounds (Preparations 44 to ___5J were obtained according to a similar manner to that of Preparation 43. Preparation 44 5-Octyloxybenzo[b] thiophene-2-carboxylic acid IR (KBr) : 1673, 1666, 1600, 1517, 1409, 1267, 1214, 1153, 865 cm "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.7Hz), 1.2-1.5 (10H, ) , 1.7-1.9 (2H, m) , 4.02 (2H, t, J=6.4Hz), 7.13 (IH, dd, J=8.9 and 0.6Hz), 7.51 (IH, d, J=0.6Hz), 7.90 (IH, d, J=9.0Hz), 7.99 (IH, s) APCI-MASS : m/z = 307 (M + +l) Preparation 45 4- [4- (4-Hexyloxyphenyl)piperazin-l-yl]benzoic acid dihydrochloride IR (KBr) : 1668, 1600, 1510, 1228 cm "1 NMR (DMSO-dg, δ) : 0.88 (3H, t, J=6.9Hz), 1.2-1.5 (6H, m) , 1.6-1.9 (2H, m) , 3.0-3.2 (4H, m) , 3.3- 3.5 (4H, m) , 3.88 (2H, t, J=6.3Hz), 6.83 (2H, d, J=9Hz), 6.9-7.1 (4H, m) , 7.79 (2H, d, J=8.8Hz), 12.32 (IH, s) APCI-MASS : m/z = 383 (M+H + ) Preparation 46 To a suspension of dimethyl terephthalate (1.94 g) and potassium t-butoxide (2.24 g) in tetrahydrofuran (30 ml) was added 4-pentyloxyacetophenone (1.59 g) in tetrahydrofuran (10 ml) at 70°C dropwise. The mixture was refluxed for 30 minutes and poured into IN HCl (50 ml) . The mixture was extracted with ethyl acetate (100 ml) and the organic layer was washed with H2O (100 ml), brine (100 ml) and evaporated under reduced pressure. The residue was triturated with acetonitrile (20 ml), collected by filtration and dried under reduced pressure to give l-(4- Methoxycarbonylphenyl) -3- (4-pentyloxyphenyl)propane-l, 3- dione (2.41 g) as yellow solid. IR (KBr) : 3475, 2956, 2923, 1720, 1606, 1508, 1284, 1176, 1108, 769 cm -1 NMR (CDCI3, δ) : 0.95 (3H, t, J=7.0Hz), 1.3-1.5 (4H, m) , 1.7-2.0 (2H, m) , 3.96 (3H, s), 4.04 (2K, t, J=6.5Hz), 6.82 (IH, s), 6.96 (2H, d, J=8.9Hz), 8.0-8.1 (4H, m) , 8.14 (2H, m, J=8.7Hz), 12-13 (IH, br) APCI-MASS : m/z = 369 (M+K + ) Preparation 47 The solution of 1- (4-Methoxycarbonylphenyl) -3- (4- pentyloxyphenyl)propane-l, 3-dione (1.00 g) and hydroxylamine hydrochloride (567 mg) in methanol (10 ml) was refluxed for 10 hours. The reaction mixture was diluted with ethyl acetate (50 ml) and washed with water (50 ml x 2), brine (50 ml) . The organic layer was dried over magnesium sulfate and the solvents were removed under reduced pressure. The residue was triturated with acetonitrile (10 ml), collected by filtration, and dried under reduced pressure to give Methyl 4- [5- (4- pentyloxyphenyl) isoxazol-3-yl]benzoate (0.74 g) . IR (KBr) : 2942, 2873, 1716, 1616, 1508, 1280, 1108 cm "1 NMR (CDC1 3 , δ) : 0.95 (3H, t, J=6.9Hz), 1.3-1.6 (4H, m) , 1.8-2.0 (2H, ) , 3.95 (3H, s) , 4.02 (2H, t, J=6.5Hz), 6.74 (IH, s), 6.99 (2H, d, J=8.8Hz), 7.76 (2H, d, J=8.8Hz), 7.93 (2H, d, J=8.5Hz), 8.14 (2H, d, J=8.5Hz) APCI-MASS : m/z = 366 (M+H) + Preparation 48 A solution of 4- [4- (8-Bromooctyloxy)phenyl]benzoic acid (1 g) in a mixture of sodium methylate (28--; solution in methanol) (10 ml) and N,N-dimethylformamide (5 ml) was refluxed for 5 hours. The reaction mixture was added to a mixture of water and ethyl acetate and adjusted to pH 2.0 with cone. HCl. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 4- [4- (8-Methoxyoctyloxy)phenyl] - benzoic acid (0.77 g) . IR (KBr) : 2935, 1685, 835, 773 cm "1 NMR (CDCI3, δ) : 1.27-1.7 (10H, m) , 1.7-1.95 (2H, m) , 3.34 (3H, s) , 3.38 (2H, t, J=6.4Hz), 4.01 (2H, t, J=6.5Hz), 6.99 (2H, d, J=8.7Hz), 7.58 (2H, d, J=8.7Hz), 7.66 (2H, d, J=8.4Hz), 8.15 (2H, d, J=8.4Hz) APCI-MASS : m/z = 339 (M + +H - H 2 0) Preparation 49 To a suspension of 1-Hydroxybenzotriazole (0.283 g) and 6-octyloxymethylpicolinic acid (0.505 g) in dichloromethane (15 ml) was added l-ethyl-3- (3' - dimethylaminopropyl) carbodiimide hydrochloride (WSCD-HCl) (0.473 g) , and stirred for 3 hours at ambient temperature. The reaction mixture was poured into water. The organic layer was taken, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give l-(6- Octyloxymethylpicolinoyl) benzotriazole 3-oxide (737 mg) . IR (Neat) : 1793, 1654, 1591, 1039 cm "1 The following compounds [Preparations 50 to _5_5) were obtained according to a similar manner to that of Preparation 49. Preparation 50 1- [4- (4-Octyloxyphenyl)piperazin-1-yl)benzoyl] - benzotriazole 3-oxide IR (KBr) : 1783, 1600, 1511, 1232, 1184 cm "1 NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.6Hz), 1.2-1.65 (10H, m) , 1.65-1.9 (2K, m) , 3.24 (4H, t, J=5.3Hz), 3.62 (4H, t, J=5.3Hz), 3.93 (2H, t, J=6.5Hz), 6.8-7.1 (6H, m) , 7.35-7.63 (3H, m) , 8.0-8.25 (3H, m) Preparation 51 l-[4-[4-[8-(l,2, 4-Triazol-1-yl) octyloxy]phenyl]- benzoyl]benzotriazole 3-oxide IR (KBr) : 1776, 1600, 1193, 983 cm "1 NMR (CDCI3, δ) : 1.2-2.0 (12K, m) , 4.03 (2H, t, J=6.4Hz), 4.18 (2H, t, J=7.1Hz), 7.02 (2H, d, J=8.7Hz), 7.4-7.63 (3H, m) , 7.63 (2H, d, J=8.7Hz), 7.79 (2H, d, J=8.3Hz), 7.95 (IH, s), 8.06 (IH, s), 8.12 (IH, d, J=7.7Hz), 8.32 (2H, d, J=8.3Hz) APCI-MASS : m/z = 511 (M + +l) Preparation 52 1- [2-Methyl-2- (4-octyloxyphenoxy)propionyl] - benzotriazole 3-oxide IR (Neat) : 2927, 1810, 1504, 1047 cm "1 Preparation 53 1- [2- (4-Octyloxyphenc..,)propionyl]benzotriazole 3-oxide IR (KBr) : 2954, 1812, 1513, 1232 cm "1 Preparation 54 1- [ (S) -2-tert-Butoxycarbonyl-l, 2, 3, 4-tetrahydro-7- octyioxyisoquinolin-3-yl-carbonyl]benzotriazole 3-oxide IR (Neat) : 2929, 1816, 1739, 1704, 1392 cm "1 Preparation 55 Succinimido 4- (4-n-octyloxyphenyl)piperazine-1- carboxylate IR (KBr) : 2925, 1758, 1743, 1513, 1241 cm "1 NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.8Hz), 1.2-1.5 (10H, m) , 1.65-1.85 (2H, m) , 2.83 (4H, s) , 3.0-3.2 (2H, m) , 3.6-3.85 (2H, m) , 3.91 (2H, t, J=6.5Hz), 6.84 (2H, dd, J=8.5 and 2.7Hz), 6.90 (2H, dd, J=8.5 and 2.7Hz) APCI-MASS : m/z = 432 (M + +l) Preparation 56 (6-Heptyloxy-2-naphthy athylsuccinimido carbonate IR (KBr) : 1878, 1832, 1787, 1735, 120? cm "1 NMR (CDCI3, δ) : 0.90 (3H, t, J=6.2Hz), 1.2-1.6 (8H, m) , 1.73-2.0 (2H, m) , 2.83 (4H, s), 4.07 (2H, t, J=6.5Hz), 5.44 (2H, s), 7.13 (IH, d, J=2.4Hz), 7.17 (IH, dd, J=8.8 and 2.4Hz), 7.44 (IH, dd. J=8 . 4 and 1 . 6Hz ) , 7 . 67 -7 . 85 ( 3H, m) Preparation 57 1- (3, 4-Dipentyloxybenzoyl)benzotriazole 3-oxide IR (KBr) : 2952, 1774, 1594, 1515, 1430, 1272, 1147, 1089 cm "1 NMR (CDC1 3 , δ) : 0.9-1.1 (6H, m) , 1.3-1.6 (8H, m) , 1.8-2.1 (4H, m) , 4.0-4.2 (4H, m) , 6.99 (IH, d, J=8.5Hz), 7.4-7.6 (3H, m) , 7.68 (IH, d, J=2.0Hz), 7.92 (IH, dd, J=8.5 and 2.0Hz), 8.10 (IH, d, J=8.5Hz) APCI-MASS : m/z = 412 (M + +l } Preparation 58 1- (7-Octyloxycoumarin-3-yl-carbonyl)benzotriazole 3-oxide IR (KBr) : 2925, 1754, 1716, 1610, 1548, 1282, 1199, 1172, 1139, 1064, 781, 750 cm "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=7.8Hz), 1.2-1.5 (10H, m) , 1.6-1.8 (2H, m) , 4.11 (2H, t, J=6.5Hz), 6.9-7.1 (2H, m) , 7.41 (IH, t, J=7.2Hz), 7.54 (IK, t, J=7.2Hz), 7.72 (IH, d, J=8.3Hz), 7.82 (IH, d, J=8.3Hz), 7.99 (IH, d, J=8.3Hz), 8.72 (IH, s) APCI-MASS : m/z = 436 (M + +l; Preparation 59 1- [4- (4-Pentyloxyphenyl) cinnamoyl]benzotriazole 3- oxide IR (Nujol) : 2854, 1778, 170S, 1620, 1597, 1494, 1459, 1434, 1377, 1350, 1250, 1188, 1138, 1086, 978 cm "1 Preoaration 60 1- (5-Octyloxybenzo [b] thiophen-2-yl-carbonyl) - benzotriazole 3-oxide IR (KBr) : 2950, 1776, 1517, 1342, 1211, 1151 cm "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.7Hz), 1.2-1.5 (10H, m) , 1.7-1.9 (2H, m) , 4.01 (2H, t, J=6.4Hz), 7.13 (IH, dd, J=8.8 and 2.4Hz), 7.42 (IH, d, J=7.1Hz), 7.5-7.6 (3H, m) , 7.72 (IH, d, J=8.4Hz), 7.89 (IH, d, J=8.8Hz), 7.9-8.1 (2H, m) APCI-MASS : m/z = 424 (M + +l) Preparation 61 1- (3-Methyl-5-octylbenzo [b] furan-2-yl-carbonyl) - benzotriazole 3-oxide IR (KBr) : 1776, 1575, 1469, 1363, 1324, 1276, 1114, 1027 cm "1 NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.7Hz), 1.2-1.5 (10H, m) , 2.6-2.8 (2H, m) , 2.71 (3H, s), 2.76 (2H, t, J=7.4Hz), 7.4-7.6 (6H, m) , 8.12 (IH, s) APCI-MASS : m/z = 406 (M + +l) Preparation 62 1- (2-Nonylbenzoxazol-5-yl-carbonyl)benzotriazole 3-oxide IR (KBr) : 2980, 1783, 1623, 1573, 1276, 1151, 1091, 989 cm "1 NMR (DMSO-dg, δ) : 0.84 <3H, t, J=6.8Hz), 1.1-1.4 (12H, m) , 1.81 (2H, t, J=7.2Hz), 2.96 (3H, t, J=7.4Hz), 7.41 (IH, t, J=7.0Hz), 7.54 (IH, t, J=7.0Hz), 7.74 (2H, t, J=7.0Hz), 7.98 (2H, d, J=7.0Hz), 8.19 (IH, s) APCI-MASS : m/z = 407 (M + +l) Preparation 63 1- [2- (4-Hexyloxyphenyl)benzimidazol-5-yl-carbonyl] - benzotriazole 3-oxide IR (KBr) : 3160, 2931, 2863, 1778, 1612, 1502, 1448, 1388, 1294, 1247, 1174, 1097, 1010, 732 cm "1 NMR (DMSO-dg, δ) : 0.89 (3H, t, J=6.7Hz), 1.2-1.5 (6H, m) , 1.7-1.8 (2H, m) , 4.08 (2H, t, J=6.4Hz), 7.16 (2H, d, J=8.7Hz), 7.6-8.4 (9H, m) , 8.3-8.6 (IH, br) APCI-MASS : m/z = 456 (M + +l) Preparation 64 1- [4- [4- (8-Methoxyoctyloxy)phenyl]benzoyl] - benzotriazole-3-oxide IR (KBr) : 2931, 1793, 1770, 1600 cm "1 NMR (CDC1 3 , δ) : 1.2-1.7 (10H, m) , 1.7-1.93 (2H, m) , 3.34 (3H, s), 3.38 (2H, t, J=6.4Hz), 4.03 (2H, t, J=6.5Hz), 7.03 (2H, d, J=8.8Hz), 7.4-7.7 (3H, m) , 7.63 (2H, d, J=8.8Hz), 7.79 (2H, d, J=8.6Hz), 8.12 (IH, d, J=8.2Hz), 8.32 (2H, d, J=8.6Hz) Preparation 65 1- [4- [4- (4-Hexyloxyphenyl)piperazin-1- yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 1770, 1604, 1510, 1232, 1186 cm "1 NMR (CDCI3, δ) : 0.91 (3H, t, J=6.6Hz), 1.2-1.6 (6H, m) , 1.6-1.9 (2H, m) , 3.1-3.3 (4H, m) , 3.5-3.7 (4H, m) , 3.93 (2H, t, J=6.5Hz), 6.87 (2H, d, J=9.2Hz), 6.96 (2H, d, J=9.2Hz), 7.00 (2H, d, J=9.0Hz), 7.3-7.7 (3H, m) , 8.10 (IH, d, J=8.2Hz), 8.15 (2H, d, J=9.0Hz) APCI-MASS : m/z = 500 (M+H + ) Preparation 66 1- [4- [5- (4-Pentyloxyphenyl) isoxazol-3-yl]benzoyl] - benzotriazole 3-oxide IR (KBr) : 2950, 2837, 1774, 1616, 1508, 1452, 1251, 1006 cm "1 NMR (CDCI3, δ) : 0.95 (3H, t, J=7.1Hz), 1.3-1.5 (4H, m) , 1.8-2.0 (2H, m) , 4.04 (2H, t, J=6.5Hz), 6.81 (IH, s), 7.0-7.1 (3H, m) , 7.4-7.6 (3H, m) , 7.80 (2H, d, J=8.8Hz), 8.0-8.2 (3H, m) , 8.40 (2H, d, J=8.4Hz) APCI-MASS : m/z = 469 (M+H) + Preparation 67 To a suspension of 1-hydroxybenzotriazole (0.20 g) and 4- (4-pentylphenyl) cinnamic acid (0.40 g) in dichloromethane (12.0 ml) was added l-ethyl-3- (3 ' - dimethylaminopropyl) carbodiimide hydrochloride (0.33 g) (WSCD-HCl), and the mixture was stirred for 12 hours at ambient temperature. The reaction mixture was diluted with dichloromethane, and washed with brine, and dried over magnesium sulfate. After magnesium sulfate was filtered off, evaporation of the filtrate and trituration with acetonitrile gave l-[4-(4- Pentylphenyl) cinnamoyl]benzotriazole 3-oxide (0.24 g) . NMR (CDCI3, δ) : 0.91 (3H, t, J=6.6Hz), 1.20-1.50 (4H, m) , 1.50-1.75 (2H, m) , 2.66 (2H, t, J=8.0Hz), 7.20-8.25 (11H, m) , 8.55 (IH, d, J=8.4Hz) APCI-MASS : m/z = 412 (M + +l) The following compounds (Preparations 68 to 7_3) were obtained according to a similar manner to that of Preparation 67. Preparation 68 1- [3- [4- (4-Pentyloxyphenyl)phenyl] -2-propanoyl] - benzotriazole 3-oxide NMR (CDCI3, δ) : 0.90-1.05 (3H, m) , 1.30-1.65 (4H, m) , 1.70-1.95 (2H, m) , 3.10-3.60 (4H, m) , 3.90-4.10 (2H, ) , 6.88-7.08 (2H, ) , 7.20-8.50 (10H, m) APCI-MASS : m/z = 430 (M + +l) Preparation 69 1- [4- (4-Heptylphenyl) cinnamoyl]benzotriazole 3-oxide NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.7Hz), 1.20-1.50 (8H, m) , 1.50-1.80 (2H, m) , 2.66 (2H, t, J=7.6Hz), 6.70-8.60 (12H, m) APCI-MASS : m/z = 440 (M + +l) Preparation 0 1- [3- [4- (4-Pentylphenyl)phenyl] -2-propanoyl] - benzotriazole 3-oxide NMR (CDCI3, δ) : 0.90 (3H, t, J=6.8Hz), 1.20-1.50 (4H, m) , 1.50-1.76 (2H, m) , 2.63 (2H, t, J=7.4Hz), 3.21 (2H, t, J=7.3Hz), 3.51 (2H, t, J=7.3Hz), 7.20-7.45 (4H, m) , 7.45-7.70 (5H, m) , 7.78 (IH, dt, J=1.0 and 7.2Hz), 8.00 (IH, d, J=8.2Hz), 8.42 (IH, d, J=8.4Hz) APCI-MASS : m/z = 414 (M + +l) Preparation 71 1- [3- (6-Heptyloxynaphthalen-2-yl)propanoyl] - benzotriazole 3-oxide NMR (CDC1 3 , δ) : 0.80-1.10 (3H, m) , 1.20-1.70 (8H, m) , 1.70-2.00 (2H, m) , 3.10-3.70 (4H, m) , 4.00- 4.18 (2H, ) , 6.80-8.50 (10H, m) APCI-MASS : m/z = 432 (M + +l) Preparation 1- [3- (6-Heptyloxynaphthalen-2-yl)propenoyl] - benzotriazole 3-oxide NMR (CDC1 3 , δ) : 0.90 (3H, t, J=6.5Hz), 1.20-1.65 (8H, m) , 1.75-1.95 (2H, m) , 4.10 (2H, d, J=6.5Hz), 6.75-8.62 (8H, m) APCI-MASS : m/z = 430 (M + +l) Preparation 73 1- (4-Hexylphenylbenzoyl)benzotriazole 3-oxide NMR (CDC1 3 , δ) : 0.90 (3H, t, J=4.4Hz), 1.2-1.5 (6H, m) , 1.6-1.8 (2H, m) , 2.68 (2H, t, J=8.0Hz), 7.32 (2H, d, J=8.2Hz), 7.4-7.7 (5H, ) , 7.81 (2H, d, J=6.6Hz), 8.10 (2H, d, J=8.1Hz), 8.32 (2H, d, J=7.6Hz) APCI-MASS : m/z = 400 (M + +l) Preparation 74 To a solution of 4-octyloxyphenol (1 g) in dimethylformamide (10 ml) and pyridine (0.364 ml) was added N,N'-disuccinimidylcarbonate (1.16 g) . The mixture was stirred for 12 hours at ambient temperature. The reaction mixture was added to a mixture of water and ethyl acetate. The organic layer was taken, and dried over magnesium s". r ate. The magnesium sulfate was filtered off, and the f ate was evaporated under reduced pressure to give 4-C- _yloxyphenylsuccinimidyl carbonate (0.59 g) . IR (KBr) : 2927, 1876, 1832, 1735 cm "1 NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.3Hz), 1.2-1.55 (10H, m) , 1.67-1.87 (2H, m) , 2.87 (4H, s), 3.94 (2H, t, J=6.5Hz), 6.89 (2H, d, J=9.2Hz), 7.17 (2H, d, J=9.2Hz) APCI-MASS : m/z = 364 (M + +l) The following compounds (Preparations 75 to j3_8) were obtained according to a similar manner to that of Preparation 1. Preparation 75 Methyl 4- [4- (6-phenylpyridazin-3-yl-oxy)phe /l]benzoate IR (KBr) : 1708, 1427, 1280, 1187, 1112 cm "1 NMR (CDC1 3 , δ) : 3.95 (3H, s), 7.2-7.7 (10H, m) , 7.92 (IH, d, J=9.2Hz), 8.0-8.2 (4H, m) APCI-MASS : m/z = 383 (M+H) + Preparation 76 Methyl 4- [4- (5-bromopentyloxy)phenyl]benzoate IR (KBr) : 2946, 2871, 1716, 1602, 1294, 1199, 1112, 837 cm "1 NMR (CDC1 3 , δ) : 1.7-2.0 (6H, m) , 3.45 (2H, t, J=6.7Hz), 3.93 (3H, s), 4.02 (2H, t, J=6.1Hz), 6.97 (2H, d, J=8.7Hz), 7.56 (2H, d, J=8.7Hz), 7.61 (2H, d, J=8.3Hz), 8.07 (2H, d, J=8.3Hz) APCI-MASS : m/z = 378 (M+H) + Preparation 77 Methyl 4- [4- (5-phenoxypentyloxy)phenyl]benzoate IR (KBr) : 2944, 2931, 1720, 1600, 1492, 1197, 1110 cm "1 NMR (CDC1 3 , δ) : 1.6-1.8 (2H, m) , 1.8-2.0 (4H, m) , 3.93 (3H, s), 4.00 (2H, t, J=6.3Hz), 4.04 (2H, t, J=6.3Hz), 6.9-7.1 (5H, m) , 7.3-7.4 (2H, m) , 7.56 (2H, d, J=8.7Hz), 7.62 (2H, d, J=8.3Hz), 8.07 (2H, d, J=8.3Hz) APCI-MASS : m/z = 391 (M+H) + Preparation 78 1- [2- (4-Cyclohexylphenylamino) ethyl] -2-oxazolidone hydrochloride IR (KBr) : 2923.6, 2852.2, 1747.2, 1683.6 cm "1 NMR (DMSO-dg, δ) : 1.1-1.5 (6H, m) , 1.6-1.9 (4H, m) , 2.3-2.6 (IH, m) , 3.3-3.5 (4H, m) , 3.58 (2H, dd, J=9.4 and 7.4Hz), 4.22 (2H, dd, J=9.4 and 7.4Hz), 7.1-7.4 (4H, m) Preparation 79 Methyl 4- [4- (8-hydroxyoctyloxy)p.-.enyl]benzoate IR (KBr) : 3250, 2933, 2856, 1724, 1602, 1436, 1292, 1199 cm "1 NMR (CDC1 3 , δ) : 1.3-1.9 (12H, m) , 3.6-3.8 (2H, br) , 3.93 (3H, s), 4.00 (2H, t, J=6.7Hz), 4.82 (IH, s), 7.68 (2H, d, J=8.7Hz), 7.56 (2H, d, J=8.7Hz), 7.62 (2H, d, J=8.3Hz), 8.07 (2H, d, J=8.3Hz) APCI-MASS : m/z = 357 (M+H + ) Preparation 80 Methyl 4- [4- (6-bromohexyloxy)phenyl]benzoate IR (KBr) : 2937, 2861, 1724, 1602, 1529, 1436, 1292, 1199, 1112 cm "1 NMR (CDCI3, δ) : 1.5-2.0 (8H, m) , 3.43 (2H, t, J=6.8Hz), 3.93 (3H, s), 4.02 (2H, t, J=6.3Hz), 6.9! (2H, d, J=8.8Hz), 7.56 (2H, d, J=8.8Hz), 7.62 (2H, d, J=8.4Hz), 8.07 (2H, d, J=8.4Hz) APCI-MASS : m/z = 391 (M+H + ) Preparation 81 4- [4- (5-Bromopentyloxy)phenyl]bromobenzene IR (KBr) : 2942, 2867, 1604, 1515, 1477, 1286 cm "1 NMR (CDCI3, δ) : 1.5-2.0 (6H, ) , 3.44 (2H, t, J=6.7Hz), 3.99 (2H, t, J=6.2Hz), 6.95 (2H, d, J=8.7Hz), 7.3-7.6 (6H, m) APCI-MASS : m/z = 399 (M+H + ) Preparation 82 8- [4- (4-Methoxycarbonylphenyl)phenoxy]octanoyl piperidine IR (KBr) : 2935, 2852, 1720, 1639, 1604, 1438, 1292 cm "1 NMR (CDCI3, δ) : 1.3-1.9 (16H, m) , 2.34 (2H, d, J=7.6Hz), 3.4-3.6 (4H, ) , 3.93 (3H, s), 3.99 (2H, t, J=6.4Hz), 6.97 (2H, d, J=8.8Hz), 7.55 (2H, d. J=8.8Hz), 7.61 (2H, d, J=8.6Hz), 8.07 (2H, d, J=8.6Hz) APCI-MASS : m/z = 438 (M+H + ) Preparation 83 Methyl 6- [4- (4-n-heptyloxyphenyl) piperazin-1- yl] nicotinate IR (KBr) : 2933, 2859, 1726, 1608, 1513, 1430, 1280, 1245 cm "1 NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.7Hz), 1.2-1.8 (10H, m) , 3.17 (4H, t, J=4.9Hz), 3.8-4.0 (9H, m) , 6.65 (IH, d, J=9.1Hz), 6.86 (2H, d, J=9.1Hz), 6.96 (2H, d, J=9.1Hz), 8.05 (IH, dd, J=9.1 and 2.3Hz), 8.82 (IH, d, J=2.3Hz) APCI-MASS : m/z = 412 (M+H + ) Preparation 8 Methyl 6- [4- [4- (8-bromooctyloxy)phenyl]piperazin-1- yl]nicotinate IR (KBr) : 2933, 2861, 1724, 1608, 1513, 1430, 1280 cm "1 NMR (CDC1 3 , δ) : 1.2-2.0 (12H, m) , 3.17 (4H, t, J=5.0Hz), 3.40 (2H, t, J=6.8Hz), 3.8-4.0 (9H, m) , 6.64 (IH, d, J=9.0Hz), 6.85 (2H, d, J=9.1Hz), 6.96 (2H, d, J=9.1Hz), 8.05 (IH, dd, J=9.0 and 2.2Hz), 8.82 (IH, d, J=2.2Hz) APCI-MASS : m/z = 504 (M+H + ) Preparation 85 4- [4- (7-Bromoheptyloxy)phenyl]bromobenzene IR (KBr) : 2935.1, 2856.1, 1604.5 cm "1 NMR (CDCI3, δ) : 1.18-1.65 (6H, m) , 1.70-2.02 (4H, ) , 3.41 (2H, t, J=6.8Hz), 3.99 (2H, t, J=6.4Hz), 6.95 (2H, d, J=8.6Hz), 7.40 (2H, d, J=8.6Hz), 7.46 (2H, d, J=8.6Hz), 7.52 (2H, d, J=8.6Hz) Preparation 86 4- [4- (8-Bromooctyloxy)phenyl]bromobenzene NMR (CDC1 3 , δ) : 1.22-1.65 (8H, m) , 1.65-1.95 (4H, m) , 3.41 (2H, t, J=6.8Hz), 3.99 (2H, t, J=6.4Hz), 6.95 (2H, d, J=8.6Hz), 7.40 (2H, d, J=8.6Hz), 7.46 (2H, d, J=8.6Hz), 7.52 (2H, d, J=8.6Hz) Preparation 87 Methyl (E)-3-[4-[4- (5-hexenyloxy)phenyl]phenyl] acrylate NMR (CDCI3, δ) : 1.50-1.72 (2H, m) , 1.72-1.95 (2H, m) , 2.05-2.14 (2H, ) , 3.82 (3H, s), 4.01 (2H, t, J=6.3Hz), 4.95-5.10 (2H, m) , 5.70-5.93 (IH, m) , 6.46 (IH, d, J=16Hz), 6.97 (2H, d, J=8.7Hz), 7.54 (2H, d, J=8.7Hz), 7.58 (4H, s), 7.72 (IH, d, J=16Hz) APCI-MASS : m/z = 337 (M + +l) Preparation 88 4-Bromo-4 '- (4-methylpentyloxy)biphenyl IR (KBr) : 2956.3, 2871.5, 1606.4 cm "1 NMR (CDCI3, δ) : 0.93 (6K, d, J=6.6Hz), 1.25-1.45 (2H, m) , 1.62 (IH, sept, J=6.6Hz), 1.72-1.93 (2H, ) , 3.98 (2H, t, J=6.6Hz), 6.95 (2H, d, J=8.6Hz), 7.30- 7.60 (6H, m) APCI-MASS : m/z = 332, 334 (M + , M + +2) The following compounds (Preparations 89 to jJO.) were obtained accc ng to a similar manner to that of Preparation 2. Preparation 89 N- [4- [2- (4-Methylpentyl) -2, 3-dihydro-4H-l, 2, 4-triazol-3- one-4-yl]phenyl]piperazine ditrifluoroacetate IR (KBr) : 1668.1, 1519.6, 1203.4, 1176.4, 1130.1 cm "1 NMR (DMSO-dg, δ) : 0.86 (6H, d, J=6.6Hz), 1.1-1.3 (2H, m) , 1.4-1.8 (3H, m) , 3.1-3.3 (4H, ) , 3.3-3.5 (4H, m) , 3.70 (2H, t, J=7.0Hz), 7.11 (2H, d, J=9.0Hz) , 7.53 (2H, d, J=9.0Hz), 8.35 (IH, s), 8.90 (2H, s) Preparation 90 1- (4-Phenylcyclohexyl)piperazine ditrifluoroacetate IR (KBr) : 1677.8, 1197.6, 1133.9 cm "1 NMR (DMSO-dg, δ) : 1.4-1.8 (4H, ) , 1.8-2.25 (4H, m) , 2.4-2.7 (IH, m) , 3.2-3.7 (9H, m) , 4.54 (2H, br s), 7.0-7.4 (5H, m) , 9.32 (IH, br s) APCI-MASS : m/z = 245 (M + +H) The following compounds (Preparations 91 to 103) were obtained according to a similar manner to that of Preparation 2. Preparation 91 Methyl 6- [4- (4-octyloxyphenyl)piperazin-1-yl]nicotinate IR (KBr) : 2923, 1726, 1608, 1515, 1278, 1116 cm "1 NMR (CDC1 3 , δ) : 0.88 (3H, t, J=6.8Hz), 1.2-1.5 (10K, m) , 1.7-1.8 (2H, ) , 3.1-3.2 (4H, m) , 3.8-4.0 (9K, m) , 6.64 (IH, d, J=9.0Hz), 6.8-7.0 (4H, m) , 8.04 (IH, dd, J=9.0 and 2.4Hz), 8.81 (IH, d, J=2.4Hz) APCI-MASS : m/z = 426 (M+H + ) Preparation 92 4- [4- [4- [2- (4-Methylpentyl) -2, 3-dihydro-4H-l, 2, 4- triazol-3-one-4-yl]phenyl]piperazin-1-yl]benzonitrile IR (KBr) : 2217.7, 1685.5 cm "1 NMR (CDCI3, δ) : 0.90 (6H, d, J=6.6Hz), 1.2-1.4 (2H, m) , 1.5-2.0 (3H, m) , 3.3-3.4 (4H, m) , 3.4-3.6 (4H, m) , 3.83 (2H, t, J=7.4Hz), 6.92 (2H, d, J=9.0Hz), 7.01 (2H, d, J=9.0Hz), 7.43 (2H, d, J=9.0Hz), 7.54 (2H, d, J=9.0Hz), 7.62 (IH, s) Preparation 93 3-Fluoro-4- [4- (4-methoxyphenyl)piperazin-l- yl]benzonitrile IR (KBr) : 2225.5, 1510.0, 1240.0 cm "1 NMR (CDC1 3 , δ) : 3.1-3.55 (8H, m) , 3.79 (3H, s), 6.7-7.1 (6H, m) , 7.3-7.5 (IH, m) Preparation 94 3-Chloro-4- [4- (4-n-hexyloxyphenyl)piperazin-1- yl]benzonitrile IR (KEr) : 2223.5, 1592.9, 1510.0, 1490.7, 1236.1 cm "1 NMR (CDCI3, δ) : 0.90 (3H, t, J=6.7Hz), 1.3-1.6 (6H, m) , 1.7-1.9 2H, m) , 3.2-3.4 (8H, m) , 3.92 (2H, t, J=6.6Hz), 6 J5 (2H, d, J=9.3Hz), 6.94 (2H, d, J=9.3Hz), 7.08 (IH, d, J=8.4Hz), 7.53 (IH, dd, J=8.4 and 1.9Hz), 7.64 (IH, d, J=1.9Hz) APCI-MASS : m/z = 398 (M + +H) Preparation 95 Ethyl 3- [4- (4-n-hexyloxyphenyl)piperazin-l-yl] -6- pyridazinecarboxylate IR (KBr) : 1729.8, 1587.1, 1511.9, 1245.8 cm "1 NMR (CDCI3, δ) : 0.90 (3H, t, J=6.5Hz), 1.2-1.4 (6H, m) , 1.44 (3H, t, J=7.1Hz), 1.6 -1.85 (2H, ) , 3.1- 3.25 (4H, m) , 3.8-4.0 (6H, m) , 4.46 (2H, q, J=7.1Hz), 6.8-7.0 (5H, m) , 7.91 (IH, d, J=9.6Hz) APCI-MASS : m/z = 413 (M + +H) Preparation 96 4- (4-Piperidinopiperidin-l-yl)benzonitrile IR (KBr) : 2217.7, 1602.6, 1511.9 cm "1 NMR (CDCI3, δ) : 1.35-1.75 (8H, m) , 1.92 (2H, d, J=12.9Hz), 2.3-2.6 (5H, m) , 2.86 (2H, td, J=12.8 and 2.6Hz), 3.90 (2H, d, J=12.8Hz), 6.84 (2H, c, J=9.1Hz), 7.46 (2H, d, J=9.1Hz) APCI-MASS : m/z = 270 (M + +H) Preparation 97 5- [4- (4-n-Hexyloxyphenyl)piperazin-l-yl]picolinonitrile IR (KBr) : 2223.5, 1575.6, 1511.9, 1241.9 cm "1 NMR (CDC1 3 , δ) : 0.90 (3H, t, J=6.5Hz), 1.2-1.55 (6H, m) , 1.7-1.85 (2H, ) , 3.22 (4H, t, J=5.1Hz), 3.52 (4H, t, J=5.1Hz), 3.92 (2H, t, J=6.5Hz), 6.86 (2H, d, J=9.4Hz), 6.93 (2H, d, J=9.4Hz), 7.13 (IK, dd, J=8.8 and 3.0Hz), 7.53 (IH, d, J=8.8Hz), 8.35 (IH, d, J=3.0Hz) APCI-MASS : m/z = 365 (M + +K) Preparation 98 4- [4- (4-Cyclohexylphenyl) piperazin-l-yl]benzonitrile IR (KBr) : 2219.7, 1606.4, 1513.8, 1238.1 cm "1 NMR (CDCI3, δ) : 1.1-1.5 (6H, m) , 1.65-2.0 (4H, m) , 2.44 (IK, m) , 3.30 (4H, t, J=5.1Hz), 3.46 (4H, t, J=5.1Hz), 6.90 (4H, d, J=8.9Hz), 7.14 (2H, d, J=8.9Hz), 7.52 (2H, d, J=8.9Hz) APCI-MASS : m/z = 346 (M + +H) Preparation 99 4- [4- (4-n-Hexylphenyl)piperazin-I-yl]benzonitrile IR (KBr) : 2925.5, 2850.3, 2213.9, 1604.5, 1513.8, 1234.2, 944.9 cm "1 NMR (CDCI3, δ) : 0.88 (3H, t, J=6.4Hz), 1.2-1.45 (6H, m) , 1.45-1.7 (2H, m) , 2.54 (2H, t, J=7.6Hz), 3.2- 3.4 (4H, m) , 3.4-3.6 (4H, ) , 6.89 (2K, d, J=8.5Hz), 6.91 (2H, d, J=8.9Hz), 7.11 (2H, d, J=8.5Hz), 7.52 (2H, d, J=8.9Hz) Preparation 100 1- [2- (4-n-Hexylphenylamino) ethyl] -2-oxazolidone hydrochloride IR (KBr) : 2925.5, 2852.2, 1753.0, 1729.8, 1267.0 cm "1 NMR (DMSO-dg, δ) : 0.85 (3H, t, J=6.5Hz), 1.1-1.4 (6H, m) , 1.45-1.7 (2H, m) , 2.56 (2H, t, J=7.6Hz), 3.3- 3.53 (4K, m) , 3.57 (2H, t, J=7.9Hz), 4.24 (2H, t, J=7.9Hz), 7.24 (4H, s) APCI-MASS : m/z = 291 (M + +H) Preparation 1Q1 4- [4- (4-Phenylcyclohexyi) piperazin-l-yl]benzonitrile IR (KBr) : 2212.0, 1602.6, 1513.8, 1249.6 cm "1 NMR (CDC1 3 , δ) : 1.3-1.8 (4H, m) , 1.9-2.2 (4H, m) , 2.3-2.6 (2H, m) , 2.75 (4H, t, J=5.0Hz), 3.34 (4H, t, J=5.0Hz), 6.86 (2H, d, J=8.9Hz), 7.1-7.4 (5H, m* , 7.49 (2H, d, J=8.9Hz) APCI-MASS : m/z = 346 {M +J -H) Preparation 102 Methyl 6- [4- (4-hydroxyphenyl)piperazin-l-yl]nicotinate IR (KBr) : 3411, 1691, 1602, 1510, 1432, 1249, 1147 cm "1 NMR (DMSO-dg, δ) : 3.0-3.1 (4H, m) , 3.7-3.9 (7H, m) , 6.67 (2H, d, J=8.8Hz), 6.84 (2H, d, J=8.8Hz), 6.93 (IH, d, J=9.1Hz), 7.97 (IH, dd, J=2. and 9.1Hz), 8.66 (IH, d, J=2.4Hz), 8.88 (IH, s) APCI-MASS : m/z = 314 (M+H) + Preparation 103 l-n-Decylindole-5-carboxylic acid IR (KBr) : 2921, 2854, 1679, 1612, 1427, 1313, 1199 cm "1 NMR (DMSO-dg, δ) : 0.84 (3H, t, J=6.8Ht), 1.1-1.3 (14H, m) , 1.6-1.8 (2H, m) , 4.19 (2H, t, J=6.9Hz), 6.57 (IH, s), 7.4-7.8 (3H, m) , 8.23 (IH, s) , 12.40 (IH, s) APCI-MASS : m/z = 302 (M+H + ) The following compounds (Preparations 104 to 111) were obtained according to a similar manner to that of Preparation Q. Preparation 104 (E) -Methyl 4- (4-n-butoxyphenyl) cinnamate IR (KBr) : 2958, 2939, 2873, 1720, 1637, 1498, 1313, 1195, 1170 cm "1 NMR (CDC1 3 , δ) : 0.98 (3H, t, J=7.3Hz), 1.4-1.8 (4H, m) , 3.81 (3H, s), 4.00 (2H, t, J=6.4Hz) , 6.45 (IH, d, J=16.0Hz), 6.97 (2H, d, J=8.7Hz), 7.5-7.7 (6H, m) , 7.72 (IH, d, J=16.0Hz) APCI-MASS : m/z = 311 (M+H + ) Preparation 105 Methyl (E) -3- [4- [4- (4-methylpentyloxy)phenyl]phenyl] - acrylate IR (KBr) : 2956.3, 2873.4, 1720.2, 1635.3, 1600.6 cm "1 NMR (CDCI3, δ) : 0.93 (6H, d, J=6.5Hz), 1.28-1.50 (2H, m) , 1.50-1.95 (3H, ) , 3.82 (3H, s) , 3.99 (2H, t, J=6.6Hz), 6.44 (IH, d, J=16.0Hz), 6.97 (2H, d, J=8.7Hz), 7.49-7.65 (6H, m) , 7.71 (IH, d, J=16Hz) APCI-MASS : m/z = 339 (M + +l) Preparation 1 Q 6 Methyl (E) -3- [4- [4- (6-fluorohexyloxy)phenyl]phenyl] - acrylate NMR (CDCI3, δ) : 1.23-2.00 (8H, ) , 3.81 (3H, s), 4.01 (2H, t, J=6.4Hz), 4.47 (2H, dt, J=47.4 and 6.0Hz), 6.45 (IH, d, J=16.0Hz), 6.96 (2H, d, J=8.8Hz), 7.45-7.63 (6H, m) , 7.72 (IH, d, J=16.0Hz) APCI-MASS : m/z = 357 (M + +l) Preparation 107 Methyl (E) -3- [4- [4- (6-methoxyhexyloxy)phenyl]phenyl] - acrylate APCI-MASS : m/z = 369 (M + ) Preparation 108 Methyl (E) -3- [4- [4- (8-methoxyoctyloxy)phenyl]phenyl] - acrylate IR (KBr) : 2935.1, 2858.0, 1722.1, 1637.3, 1602.6 cm "1 NMR (CDC1 3 , δ) : 1.30-1.70 (10H, m) , 1.70-1.92 (2H, m) , 3.33 (3H, s), 3.37 (2H, t, J=6.5Hz), 3.81 (3H, s), 4.00 (2H, t, J=6.5Hz), 6.45 (IH, d, J=16.0Hz), 6.97 (2H, d, J=8.8Hz), 7.46-7.78 (6H, m) , 7.72 (IK, d, J=16.0Hz) APCI-MASS : m/z = 397 (M + +l) Preparation 109 Methyl (E) -3- [4- (4-hydroxyphenyl)phenyl] acrylate IR (KBr) : 3409.5, 1695.1 cm "1 NMR (DMSO-dg, δ) : 3.73 (3H, s), 6.64 (IH, d, J=16Hz), 6.85 (2H, d, J=8.6Hz), 7.50-7.83 (5H, m) APCI-MASS : m/z = 255 (M + +l) Preparation 110 Methyl (E) -3- [4- [4- (7-methoxyheptyloxy)phenyl]phenyl] - acrylate NMR (CDCI3, δ) : 1.32-1.70 (8H, m) , 1.70-1.92 (2H, m) , 3.34 (3H, s), 3.38 (2H, t, J=6.4Hz), 3.81 (3H, s) , 4.00 (2H, t, J=6.5Hz), 6.45 (IH, d, J=16.0Hz), 6.97 (2H, d, J=8.8Hz), 7.47-7.65 (6H, m) , 7.70 (IH, d, J=16H∑ APCI-MASS : ./z = 383 (M + +l) Preparation Ul Methyl (E)-3-[4-[4- (7-fluoroheptyloxy)phenyl]phenyl] - acrylate IR (KBr) : 2937.1, 2861.8, 1722.1, 1637.3, 1600.6 cm "1 The following compound was obtained according to a similar manner to that of Preparation 20. Preparation 112 Methyl 3- [4- (4-heptylphenyl) phenyl]propanoate NMR (CDC1 3 , δ) : 0.88 (3H, t, J=6.5Hz), 1.15-1.50 (8H, m) , 1.50-1.77 (2H, m) , 2.52-2.73 (4K, ) , 2.99 (2K, t, J=7.8Hz), 3.68 (3H, s), 7.18-7.35 (4H, m) , 7.40- 7.58 (4H, m) APCI-MASS : m/z = 339 (M + +l) The following compounds (Preparation 113 to 16 ) were obtained according to a similar manner to that of Preparation ____.. Preparation 113 4- (4-0ctylphenyl) -2, -dihydro-3H-l, 2, 4-triazol-3-one-2- yl-acetic acid IR (KBr) : 2923.6, 1704.8, 1224.6 cm "1 NMR (DMSO-dg, δ) : 0.85 (3H, t, J=6.7Hz), 1.1-1.4 (10H, m) , 1.4-1.7 (2H, m) , 2.60 (2H, t, J=7.2Hz), 4.38 (2H, s), 7.32 (2H, d, J=8.5Hz), 7.58 (2H, d, J=8.5Hz), 8.43 (IH, s) Preparation 114 l-Heptyl-4- (4-carboxyphenyl)pyrazole IR (KBr) : 3106, 2917, 1687, 1612, 1425, 1295, 1184, 952, 860, 773 cm "1 NMR (DMSO-dg, δ) : 0.85 (3H, t, J=6.8Hz), 1.1-1.4 (8H, m) , 1.7-1.9 (2H, m) , 4.11 (2H, t, J=7.0Hz), 7.69 (2H, d, J=8.5Hz), 7.91 (2H, d, J=8.5Hz), 7.98 (IH, s), 8.32 (IH, s), 12.82 (IH, br) APCI-MASS : m/z = 287 (M+H + ) Preparation 115 6- [4- (4-Octyloxyphenyl)piperazin-l-yl]nicot_nic acid IR (KBr pelet) : 2919, 2854, 1697, 1608, 1515, 1429, 1263, 1245, 1228 cm "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.7Hz), 1.1-1.5 (10H, m) , 1.6-1.8 (2H, m) , 3.0-3.2 (4H, m) , 3.7-3.9 (4H, m) , 3.88 (2H, t, J=6.4Hz), 6.7-7.0 (5H, m) , 7.95 (IH, dd, J=9.0 and 1.1Hz), 8.64 (IK, d, J=l.lHz) APCI-MASS : m/z = 412 (M+H + ) Preparation 116 2- (4-Hexyloxyphenyl)benzoxazole-5-carboxylic acid IR (KBr) : 2952, 1689, 1677, 1619, 1500, 1415, 1299, 1172, 1024 cm "1 NMR (DMSO-dg, δ) : 0.89 (3H, t, J=6.7Hz), 1.2-1.5 (6H, m) , 1.7-1.9 (2H, m) , 4.09 (2H, t, J=6.5Hz), 7.16 (2H, d, J=8.8Hz), 7.84 (IH, d, J=8.5Hz), 8.01 (IH, dd, J=8.5 and 1.5Hz), 8.15 (2H, d, J=8.8Hz), 8.26 (IH, d, J=1.5Hz) APCI-MASS : m/z = 340 (M+H + ) Preparation 117 4- [4- (4-n-Butyloxyphenyl) phenyl]benzoic acid IR (KBr) : 2958, 2873, 1689, 1600, 1537, 1396 cm "1 preparation 118 6- (4-Heptyloxyphenyl) nicotinic acid IR -KBr) : 2858, 1699, 1674, 1589, 1425, 1180, 1016, 781 cm "1 NMR DMSO-dg, δ) : 0.87 (3H, t, J=6.7Hz), 1.2-1.5 (8H, ) , 1.6-1.8 (2H, m) , 4.04 (2H, t, J=6.4Hz), 7.06 (2H, d, J=8.9Hz), 8.03 (IH, d, J=8.2Hz), 8.13 (2H, d, J=8.9Hz), 8.27 (IH, dd, J=8.2 and 2.2Hz), 9.09 (IH, d, J=2.2Hz), 13.31 (IH, br) APCI-MASS : m/z = 314 (M+H + ) Preparation 119 5- (4-0ctyloxyphenyl) isoxazole-3-carboxylic acid IR (KBr pelet) : 2923, 2852, 1704, 1612, 1440, 1272, 1178 cm -1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.8Hz), 1.2-1.6 (10H, m) , 1.6-1.9 (2H, m) , 4.03 (2H, t, J=6.5Hz), 7.08 (2H, d, J=8.9Hz), 7.25 (IH, s), 7.86 (2H, d, J=8.9Hz) APCI-MASS : m/z = 318 (M+H + ) Preparation 120 2- (2-Octyloxypyridin-5-yl)benzoxazole-5-carboxylic acid IR (KBr) : 2954, 2923, 2854, 1697, 1683, 1625, 1488, 1290 cm "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=7.6Hz), 1.2-1.5 (10H, m) , 1.7-1.8 (2H, m) , 4.36 (2H, t, J=6.6Hz), 7.04 (IH, d, J=8.7Hz), 7.88 (IH, d, J=8.5Hz), 8.04 (IH, dd, J=8.5 and 1.6Hz), 8.29 (IH, d, J=1.6Hz), 8.43 (IH, dd, J=8.7 and 2.4Hz), 8.99 (IH, d, J=2.4Hz), 13.0-13.2 (IH, br) APCI-MASS : m/z = 369 (M+H + ) Preparation 121 2- [4- (4-Hexylphenyl)phenyl]benzoxazole-5-carboxylic acid IR (KBr) : 2923, 2854, 1683, 1411, 1299, 1054 cm "1 APCI-MASS : m/z = 400 (M+H + ) Preparation 122 6- [4- (4-n-Butyloxyphenyl)phenyl]nicotinic acid IR (KBr) : 3406, 2958, 1691, 1591, 1394, 1284, 1253 cm "1 NMR (DMSO-dg, δ) : 0.94 (3H, t, J=7.3Hz), 1.4-1.8 (4H, m) , 4.01 (2H, t, J=6.4Hz), 7.02 (2H, d, J=8.7Hz), 7.57 (2H, d, J=8.7Hz), 7.61 (2H, d, J=8.2Hz), 7.83 (2H, d, J=8.2Hz), 8.05 (IH, d, J=8.5Hz), 8.22 (IH, dd, J=8.5 and 1.6Hz), 9.14 (IH, d, J=1.6Hz) APCI-MASS : m/z = 348 (M+H + ) Preparation 123 4- [4- (5-Phenoxypentyloxy)phenyl]benzole acid NMR (DMSO-dg, δ) : 1.5-1.7 (2H, m) , 1.7-1.9 (4H, ) , 3.98 (2H, t, J=6.3Hz), 4.05 (2H, t, J=6.1Hz), 6.8- 7.0 (3H, m) , 7.05 (2H, d, J=8.6Hz), 7.25 (2H, t, J=8.2Hz), 7.68 ( d, J=8.5Hz), 7.75 (2H, d, J=8.2Hz), 7.98 (_.-, d, J=8.2Hz), 12.8-13.0 (IH, br s) APCI-MASS : m/z = 375 (M-H) " Preparation 124 4- [5- (4-n-Hexyloxyphenyl) -1,3, 4-oxadiazol-2-yl]benzoic acid IR (KBr) : 2935, 2854, 1685, 1612, 1495, 1425, 1286, 1251 cm "1 NMR (DMSO-c-, δ) : 0.89 (3H, t, J=6.7Hz), 1.2-1.5 (6H, ) , l.ϋ-1.9 (3H, m) , 4.12 (2H, t, J=6.4Hz), 7.19 (2H, d, J=8.7Hz), 8.08 (2H, d, J=8.7Hz), 8.18 (2H, d, J=8.4Hz), 8.24 (2H, d, J=8.4Hz) APCI-MASS : m/z = 367 (M+H) + Preparation 125 4- [5- (4-n-Hexyloxyphenyl) -1, 3, 4-thiadiazol-2-yl]benzoic acid IR (KBr) : 2952, 258^, 1699, 1604, 1517, 1432, 1251, 1174 cm "1 NMR (DMSO-dg, δ) : 0 9 (3H, t, J=6.7Hz), 1.3-1.9 (8H, m) , 4.04 (2H, t, J=6.3Hz), 7.13 (2H, d, J=8.8Hz), 7.97 (2H, d, J=8.8Hz), 8.11 (4H, s) APCI-MASS : m/z = 383 (M+H) + Preparation 126 5- (4-Octyloxyphenyl) -l-methylpyrazole-3-carboxylic acid IR (KBr pelet) : 2950, 2923, 1695, 1450, 1282, 1251, 956 cm "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.8Hz), 1.2-1.5 (10H, m) , 1.6-1.8 (2H, m) , 3.98 (2H, t, J=6.5Hz), 4.10 (3H, s), 6.95 (IH, d, J=8.8Hz), 7.18 (IH, ε), 7.73 (2H, d, J=8.8Hz), 13.37 (IH, br) APCI-MASS : m/z = 331 (M+H "1" ) Preparation 127 4- [3- (4-n-Pentyloxyphenyl)pyrazol-5-yl]benzoιc acid IR (KBr) : 3224, 2956, 1692, 1614, 1506, 1251 cm "1 NMR (DMSO-dg, δ) : 0.91 (3H, t, J=6.9Hz), 1.3-1.5 (4K, m) , 1.6-1.8 (2H, m) , 4.00 (2H, t, J=6.5Hz), 7.02 (2H, d, J=8.8Hz), 7.19 (IH, s), 7.75 (2H, d, J=8.8Hz), 7.95 (2H, d, J=8.7Hz), 8.02 (2H, d, J=8.7Hz), 12.8-13.3 (2H, br) APCI-MASS : m/z = 351 (M+H + ) Preparation 128 5- [4- (4-n-Butoxyphenyl)phenyl] furan-2-carboxylic acid IR (KBr) : 2958, 2873, 1679, 1487, 1253, 1166 cm "1 NMR (DMSO-dg, δ) : 0.95 (3H, t, J=7.3Hz), 1.3-1.8 (4H, m) , 4.02 (2H, t, J=6.3Hz), 7.03 (2H, d, J=8.6Hz), 7.17 (IH, d, J=3.6Hz), 7.33 (IH, d, J=3.6Hz), 7.66 (2H, d, J=8.6Hz), 7.74 (2H, d, J=8.4Hz), 7.86 (2H, d, J=8.4Hz) , 13.1 (IH, br s) APCI-MASS : m/z = 337 (M+H) τ Preparation 129 3- (S) -Hydroxyhexadecanoic acid IR (KBr) : 1679.7, 1467.6, 1224.6 cm "1 NMR (CDC1 3 , δ) : 0.88 (3H, t, J=6.4Hz), 1.1-1.7 (24H, m) , 2.35-2.65 (2H, m) , 4.03 (IH, m) , 5.41 (IH, br s) Preparation 130 6- [4- (4-n-Hexyloxyphenyl)piperazin-l-yl]pyridazine-3- carboxylic acid IR (KBr) : 1697.1, 1589.1, 1515.8, 1448.3 cm "1 NMR (DMSO-dg, δ) : 0.87 (3H, t, J=6.4Hz), 1.2-1.5 (6H, m) , 1.6-1.8 (2H, m) , 3.0-3.2 (4H, ) , 3.7-4.0 (6H, m) , 6.83 (2H, d, J=9.0Hz), 6.95 (2H, d, J=9.0Hz), 7.36 (IH, d, J=9.6Hz), 7.86 (IH, d, J=9.6Hz), 11.68 (IH, s) Preparation 131 4- [4- [1- (4-n-Hexyloxyphenyl)piperidin- -yl]piperazin-l- yl]benzoic acid hydrochloride IR (KBr) . 1699.0, 1608.3, 1513.8 cm "1 NMR (DMSO-dg, δ) : 0.88 (3H, t, J=6.5Hz), 1.2-1.5 (6H, m) , 1.6-1.8 (2H, m) , 2.0-2.45 (3H, m) , 3.2-3.8 (12H, m) , 3.94 (2H, t, J=6.4Hz), 4.03 (2H, d, J=llHz), 6.95 (2H, d, J=8.7Hz), 7.07 (2H, d, J=8.9Hz), 7.32 (2H, br s) , 7.83 (2H, d, J=8.9Hz) APCI-MASS : m/z = 466 (M + +H) Preparation 132 6- (8-Methoxyoctyloxy) -2-naphthoic acid IR (KBr) : 2937.1, 2854.1, 1677.8, 1211.1 cm "1 NMR (DMSO-dg, δ) : 1.2-1.6 (10H, m) , 1.7-1.9 (2H, m) , 3.20 (3H, s), 3.29 (2H, t, J=6.5Hz), 4.11 (2H, t, J=6.4Hz), 7.23 (IH, dd, J=9.0 and 2.3Hz), 7.39 (IH, d, J=2.3Hz), 7.85 (IH, d, J=8.7Hz), 7.93 (IH, d, J=8.7Hz), 7.99 (IH, d, J=9.0Hz), 8.51 (IH, s) , 12.9 (IH, s) Preparation 133 Mixture of (E) and (Z) -3- [4- (4-Heptylphenyl)phenyl] -2- butenoic acid NMR (CDC1 3 , δ) : 0.88 (3H, t, J=6.6Hz), 1.15-1.50 (8H, m) , 1.52-1.75 (2H, m) , 2.63 and 3.62 (total 3H, each s), 2.53-2.75 (2H, m) , 6.24 and 5.68 (total IH, each s), 7.19-7.35 (2H, m) , 7.47-7.70 (6H, m) APCI-MASS : m/z = 337 (M + +l), 351 (methyl ester ÷ +l) Preparation 134 3- [4- (4-Heptylphenyl)phenyl]propanoic acid NMR (CDC1 3 , δ) : 0.88 (3H, t, J=6.6Hz), 1.13-1.48 (8H, m) , 1.48-1.75 (2H, m) , 2.52-2.83 (4H, ) , 3.00 (2H, t, J=7.8Hz), 7.15-7.35 (4H, m) , 7.40-7.60 (4H, m) APCI-MASS : m/z = 323 (M + -l) Preparation 135 4- (4-n-Heptylphenyl)benzoyl-carboxylic acid NMR (CDCI3, δ) : 0.88 (3H, t, J=6.6Hz), 1.13-1.50 (8H, m) , 1.50-1.75 (2H, m) , 2.66 (2H, t, J=7.7Hz), 7.20- 7.40 (2H, m) , 7.50-7.66 (2H, m) , 7.66-7.84 (2H, m) , 8.40-8.60 (2H, m) APCI-MASS : m/z = 323 (M + -l) Preparation 136 6-Hexylnaphthalene-2-carboxylic acid NMR (CDCI3, δ) : 0.89 (3H, t, J=6.8Hz), 1.15-1.53 (6H, m) , 1.55-1.84 (2H, m) , 2.80 (2H, t, J=7.6Hz), 7.42 (IH, dd, J=1.7 and 8.4Hz), 7.67 (IH, s), 7.84 (IH, d, J=8.6Hz), 7.90 (IH, d, J=8.4Hz), 8.09 (IH, dd, J=1.7 and 8.6Hz), 8.68 (IH, s) APCI-MASS : m/z = 257 (M + +l), 271 (methyl ester + +l) Preparation 137 3- (E) - [4- [4- (7-Methoxyheptyloxy)phenyl]phenyl] acrylic acid NMR (DMSO-dg, δ) : 1.20-1.60 (8H, m) , 1.60-1.83 (2H, m) , 3.21 (3H, s), 3.25-3.60 (2H, m) , 4.01 (2H, t, J=6.4Hz), 6.54 (IH, d, J=16.0Hz), 7.02 (2H, d. - 3 - J=8.8Hz), 7.55-7.80 (7H, m) APCI-MASS m/z 369 (M + ~i; Preparation 138 3-(E)-[4-[4- (8-Methoxyoctyloxy)phenyl]phenyl] acrylic acid IR (KBr) : 3037.3, 2933.2, 2858.0, 2551.4, 1706.7, 1677.8, 1629.6, 1602.6 cm -1 NMR (DMSO-dg, δ) : 1.18-1.55 (10H, m) , 1.65-1.83 (2H, m) , 3.18-3.45 (5H, m) , 4.01 (2H, t, J=6.5Hz), 6.53 (IH, d, J=16.0Hz), 7.02 (2H, d, J=8.8Hz), 7.50-8.80 (7H, ) APCI-MASS : m/z = 383 (M + -^l) Preparation 139 3- (E) - [4- [4- (5-Hexenyloxy)phenyl]phenyl]acrylic acid NMR (DMSO-dg, δ) : 1.42-1.63 (2H, m) , 1.63-1.85 (2H, m) , 2.00-2.20 (2H, m) , 4.03 (2H, t, J=6.3Hz), 4.90- 5.15 (2H, m) , 5.68-5.97 (IH, m) , 6.54 (IH, d, J=16Hz), 7.02 (2H, d, J=8.7Hz), 7.50-7.80 (7H, m) APCI-MASS : m/z = 323 (M + +l) Preparation 14 Q 3- (E) - [4- [4- (4-Methylpentyloxy)phenyl]phenyl]acrylic acid IR (KBr) : 2956.3, 2869.6, 2713.4, 2599.6, 1689.3, 1627.6, 1602.6 cm "1 NMR (DMSO-dg, δ) : 0.89 (6H, d, J=6.5Hz), 1.15-1.43 (2H, m) , 1.48-1.90 (3H, m) , 4.00 (2H, t, J=6.7Hz), 6.54 (IH, d, J=16Hz) , 7.C2 (2H, d, J=8.7Hz), 7.50- 7.90 (7H, m) APCI-MASS : m/z = 325 (M + +l) Preparation Hi 3- (E) - [4- [4- (6-Fluorohexyloxy)phenyl]phenyl] acrylic acid NMR (CDCI3, δ) : 1.39-2.00 (8H, ) , 4.01 (2H, t, J=6.5Hz), 4.47 (2H, dt, J=47.3 and 6.0Hz), 6.49 (IH, d, J=15.9Hz), 6.98 (2H, d, J=8.7Hz), 7.40-7.70 (6H, m) , 7.81 (IH, d, J=15.9Hz) APCI-MASS : m/z = 343 (M * +l) Preparation 142 3- (E) - [4- [4- (6-Methoxyhexyloxy)phenyl]phenyl] acrylic acid NMR (DMSO-dg, δ) : 1.22-1.63 (6H, m) , 1.63-1.88 (2H, m) , 3.21 (3H, s), 3.22-3.40 (2H, m) , 4.00 (2K, t, J=6.5Hz), 6.54 (IH, d, J=15.8Hz), 7.02 (2H, d, J=8.7Hz), 7.50-7.84 (7H, ) APCI-MASS : m/z = 369 (methyl ester, M + +l) Preparation 143 4- [4- [8- (Tetrahydropyran-2-yl- oxy) octyloxy]phenyl]benzoic acid IR (KBr) : 2935, 1697, 1683, 1604, 1303, 1290, 1197 cm "1 NMR (DMSO-dg, δ) : 1.2-1.8 (18H, m) , 3.3-3.9 (4H, m) , 4.01 (2H, t, J=6.3Hz), 4.5-4.6 (IH, m) , 7.03 (2H, d, J=8.7Hz), 7.67 (2H, d, J=8.7Hz), 7.74 (2H, d, J=8.3Hz), 7.98 (2H, d, J=8.3Hz) APCI-MASS : m/z = 425 (M-H + ) Preparation 144 4- [3- (4-n-Hexyloxyphenyl)pyrazol-5-yl]benzoic acid IR (KBr) : 2956, 2935, 1693, 1614, 1508, 1432, 1251, 1178 cm "1 NMR (DMSO-dg, δ) : 0.89 (3H, t, J=6.4Hz), 1.2-1.5 (6H, m) , 1.6-1.8 (2H, m) , 4.00 (2H, t, J=6.4Hz), 7.02 (2H, d, J=8.7Hz), 7.12 (IH, s), 7.74 (2H, d, J=8.7Hz), 7.95 (2H, d, J=8.8Hz), 8.01 (2H, d, J=8.8Hz), 13.17 (IH, s) APCI-MASS : m/z = 365 (M+H + : Preparation 145 4- [4- [4- (6-Methoxyhexyloxy)phenyl]phenyl]benzoic acid IR (KBr) : 2939, 2861, 1685, 1602, 1430, 1286, 1128 cm "1 NMR (DMSO-dg, δ) : 1.3-1.8 (8H, m) , 3.21 (3H, s), 3.3-3.4 (2H, m) , 4.01 (2H, t, J=6.5Hz), 7.04 (2H, d, J=8.6Hz), 7.66 (2H, d, J=8.6Hz), 7.7-7.9 (6H, m) , 8.03 (2H, d, J=8.2Hz) APCI-MASS : m/z = 405 (M+H + ) Preparation 146 4- [5- [4- (8-Methoxyoctyloxy)phenyl] -1, 3, 4-thiadiazol-2- yl]benzoic acid IR (KBr) : 2931, 2854, 1691, 1602, 1251 cm "1 NMR (DMSO-dg, δ) : 1.2-2.0 (12H, m) , 3.20 (3H, s), 3.29 (2H, t, J=6.4Hz), 4.04 (2H, t, J=6.4Hz), 7.13 (2H, t, J=8.8Hz), 7.9-8.2 (6H, m) , 13.95 (IH, br) APCI-MASS : m/z = 441 (M+H + ) Preparation 1 7 4- (4-n-Butoxyphenyl) cinnamic acid IR (KBr) : 2958, 2871, 1695, 1625, 1498, 1249 cm "1 NMR (DMSO-dg, δ) : 0.94 (3H, t, J=7.3Hz), 1.44 (2H, tq, J=7.0 and 7.3Hz), 1.71 (2H, tt, J=7.0 and 6.4Hz), 4.01 (2H, t, J=6.4Hz), 6.54 (IH, d, J=16.0Hz), 7.02 (2H, d, J=8.7Hz), 7.6-7.9 (7H, m) A * "I-MASS : m/z = 297 (M+H + ) Preparation 149 4- [5- (4-Cyclohexylphenyl) -1, 3, 4-thiadiazol-2-yl]benzoic acid IR (KBr) : 2925, 2850, 1683, 1429, 1292 cm "1 NMR (DMSO-dg, δ) : 1.1-1.5 (5H, m) , 1.6-2.0 (5H, m) , 2.4-2.6 (IH, m) , 7.45 (2H, d, J=8.3Hz), 7.96 (2H, d, J=8.3Hz), 8.13 (4H, s) APCI-MASS : m/z = 365 (M+H) + Preparation 149 4- [5- [4- (Piperidin-l-yl)phenyl] -1, 3, 4-thiadiazol-2-yl] - benzoic acid IR (KBr) : 2931, 2854, 1685, 1604, 1415, 1238 cm "1 NMR (DMSO-dg, δ) : 1.61 (6H, s), 3.31 (4H, s) , 7.05 (2H, d, J=9.0Hz), 7.83 (2H, d, J=9.0Hz), 8.10 (4H, s) APCI-MASS : m/z = 366 (M+H) + Preparation 150 4- [5- [4- [4-n-Propyloxyphenyl)phenyl] -1,3, 4-oxadiazol-2- yl]benzoic acid IR (KBr) : 2939, 1689, 1606, 1488, 1429, 1290 cm "1 NMR (DMSO-dg, δ) : 1.00 (3H, t, J=7.3Hz), 1.76 (2H, tq, J=6.5 and 7.3Hz), 4.00 (2H, t, J=6.5Hz), 7.07 (2H, d, J=8.8Hz), 7.70 (2H, d, J=8.5Hz), 7.78 (2H, d, J=8.8Hz), 7.90 (2H, d, J=8.5Hz), 8.0-8.4 (4H, m) APCI-MASS : m/z = 401 (M+H) + Preparation 151 4- (5-n-Nonyl-l, 3, 4-oxadiazol-2-yl)benzoic acid IR (KBr) : 2919, 2852, 1685, 1565, 1430, 1284 cm -1 NMR (DMSO-dg, δ) : 0.84 (3H, t, J=6.5Hz), 1.2-1.5 (12H, m) , 1.7-1.9 (2H, m) , 2.94 (2H, t, J=7.4Hz), 8.0-8.2 (4H, m) , 13.35 (IH, s) APCI-MASS : m/z = 317 (M+H + ) Preparation 152 4- [3- (4-n-Hexyloxyphenyl) -1, 2, 4-oxadiazol-5-yl]benzoic acid IR (KBr) : 2942, 2869, 1695, 1421, 1251 cm "1 NMR (DMSO-dg, δ) : 0.6 - (3H, t, J=6.8Hz), 1.2-1.8 (8H, m) , 4.06 (2H, t, J=6.5Hz), 7.13 (2H, d, J=8.9Hz), 8.03 (2H, d, J=8.9Hz), 8.17 (2H, d, J=8.5Hz), 8.28 (2H, d, J=8.5Hz) APCI-MASS : m/z = 367 (M+H) + Preparation 153 4- [4- [4- (5-Methoxypentyloxy) phenyl]phenyl]phenylacetic acid IR (KBr) : 2939, 2861, 1699, 1253, 1182, 1124 cm -1 NMR (DMSO-dg, δ) : 1.4-1.9 (6H, m) , 3.22 (3H, s), 3.39 (2H, t, J=6.2Hz), 3.61 (2H, s), 4.01 (2H, t, J=6.4Hz), 7.02 (2H, d, J=8.8Hz), 7.35 (2H, d, J=8.2Hz), 7.6-7.8 (8H, ) APCI-MASS : m/z = 405 (M+H + ) Preparation 154 4- [5- (4-n-Octyloxyphenyl) -1, 3, 4-thiadiazol-2-yl]benzoic acid IR (KBr) : 2921, 2856, 1691, 1432, 1251 cm "1 NMR (DMSO-dg, δ) : 0.87 (3H, t, J=6.7Hz), 1.2-1.5 (10H, m) , 1.7-1.9 (2H, m) , 4.07 (2H, t, J=6.5Hz), 7.13 (2H, d, J=8.9Hz), 7.97 (2H, d, J=8.9Hz), 8.12 (4H, s) APCI-MASS : m/z = 411 (M+H + ) Preparation 155 4- [5- (4-Tran oentylcyclohexyl) -1, 3, 4-thiadiazol-2- yi]benzoic acid IR (KBr) : 29_ , 284c, 1677, 1430, 1294 cm "1 NMR (DMSO-dg, δ) : 0.87 (3H, t, J=6.9Hz), 1.0-1.4 (11H, m) , 1.5-1.6 (2H, m) , 1.8-2.0 (2H, m) , 2.1-2.3 (2H, m) , 3.1-3.3 (IH, m) , 8.07 (4H, s) APCI-MASS : m/z = 359 (M+H + ) Preparation 156 4- [3- (4-n-PentyloxyphenyI) isoxazoI-5-yl]benzoιc acid IR (KBr) : 2925, 2869, 1699, 1687, 1612, 1432, 1251, 1178 cm "1 NMR (DMSO-dg, δ) : 0.91 (3H, t, J=6.9Hz), 1.2-1.5 (4H, m) , 1.7-1.9 (2H, m) , 4.04 (2H, t, J=6.5Hz), 7.09 (2H, d, J=8.8Hz), 7.69 (IK, s), 7.85 (2H, d, J=8.8Hz), 8.01 (2H, d, J=8.5Hz), 8.11 (2H, d, J=8.5Hz) APCI-MASS : m/z = 352 (M+H + ) Preparation 157 4- [5- [4- (8-Methoxyoctyloxy)phenyl] -1,3, 4-oxadiazol-2- yl]benzoic acid IR (KBr) : 2967, 2937, 2877, 1687, 1290 cm "1 NMR (DMSO-dg, δ) : 1.2-1.6 (10H, m) , 1.7-1.9 (2H, m) , 3.20 (3H, s), 3.29 (2H, t, J=6.4Hz), 4.08 (2H, t, J=6.5Hz), 7.17 (2H, d, J=8.9Hz), 8.07 (2H, d, J=8.9Hz), 8.15 (2H, d, J=8.6Hz), 8.24 (2H, d, J=8.6Hz) APCI-MASS : m/z = 425 (M+H) + Preparation 158 4- [4- (6-Phenylpyridazin-3-yl-oxy)phenyl]benzoic acid IR (KBr) : 1700, 1687, 1608, 1427, 1284, 1186 cm "1 NMR (DMSO-dg, δ) : 7.40 (2H, d, J=8.6Hz), 7.5-7.7 (4H, m) , 7.7-7.9 (4H, ) , 7.9-8.1 (4H, m) , 8.35 (IH, d, J=9.2Hz) , 12.99 (IH, br s) APCI-MASS : m/z = 369 (M+H) + Preparation 159 4- [5- (4-n-Octyloxyphenyl) -1, 3, 4-oxadiazol-2-yl]benzoic acid IR (KBr) : 2921, 2852, 1685, 1612, 1496, 1425, 1288, 1251 cm "1 NMR (DMSO-dg, δ) : 0.87 (3H, t, J=6.7Hz), 1.2-1.5 (10H, m) , 1.7-1.9 (2H, m) , 4.08 (2H, t, J=6.4Hz), 7.17 (2H, d, J=8.7Hz), 8.07 (2H, d, J=8.7Hz), 8.15 (2H, d, J=8.5Hz), 8.24 (2H, d,' J=8.5Hz), 13.36 (IH, br) APCI-MASS : m/z = 395 (M+H + ) Preparation 160 4- [2- (4-n-Hexyloxyphenyl)pyrimidin-6-yl]benzoic acid IR (KBr) : 2944, 2863, 1697, 1585, 1415, 1386, 1253 cm "1 NMR (DMSO-dg, δ) : 0.89 (3H, t, J=6.7Hz), 1.2-1.6 (6H, m) , 1.7-1.9 (2H, m) , 4.07 (2H, t, J=6.6Hz), 7.10 (2H, d, J=8.9Hz), 8.00 (IH, d, J=5.2Hz), 8.13 (2H, d, J=8.4Hz), 8.44 (2H, d, J=5.9Hz), 8.47 (2H, d, J=5.9Hz), 8.95 (IH, d, J=5.2Hz) APCI-MASS : m/z = 377 (M+H + ) Preparation 161 4- [4- (7-Piperidinocarbonylheptyloxy)phenyl]benzoic acid IR (KBr) : 2933, 2858, 1697, 1677, 1637, 1604, 1429, 1249 cm "1 NMR (DMSO-dg, δ) : 1.2-1.8 (16H, m) , 2.26 (2H, t, J=7.5Hz), 3.2-3.5 (4H, m) , 4.01 (2H, t, J=6.4Hz), 7.03 (2H, d, J=8.8Hz), 7.67 (2H, d, J=8.8Hz), 7.74 (2H, d, J=8.4Hz), 7.98 (2H, d, J=8.4Hz) APCI-MASS : m/z = 424 (M+H + ) Preparation 162 6- [4- (4-n-Heptyloxyρhenyl)piperazin-l-yl]nicotinic acid IR (KBr) : 2929, 2854, 1695, 1673, 1606, 1577, 1515, 1421, 1245 cm "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.7Hz), 1.2-1.5 (8H, m) , 1.6-1.8 (2H, m) , 3.0-3.2 (4H, ) , 3.6-3.8 (4H, m) , 3.87 (2H, t, J=6.5Hz), 6.8-7.2 (5H, m) , 7.95 (IH, dd, J=8.9 and 2.3Hz), 8.62 (IH, d, J=2.3Hz) APCI-MASS : m/z = 398 (M+H + ) Preparation 163 6- [4- [4- (8-Methoxyoctyloxy)phenyl]piperazin-l-yl] - nicotinic acid IR (KBr) : 2933, 2856, 1697, 1672, 1605, 1511, 1421, 1245 cm "1 NMR (DMSO-dg, δ) : 1.2-1.8 (12H, m) , 3.08 (4H, t, J=5.0Hz), 3.20 (3H, s), 3.28 (2H, t, J=6.5Hz), 3.78 (4H, t, J=4.6Hz), 3.87 (2H, t, J=6.4Hz), 6.8-7.0 (5H, ) , 7.95 (IH, dd, J=9.0 and 2.2Hz), 8.65 (IH, d, J=2.2Hz), 12.54 (IH, s) APCI-MASS : m/z = 442 (M+H + ) Preparation 164 4- [5- [4- (4-n-Propyloxyphenyl) phenyl] -1, 3, 4-thiadiazol-2- yl]benzoic acid IR (KBr) : 1685, 1537, 1423, 817 cm "1 NMR (DMSO-dg, δ) : 1.00 (3H, t, J=6.7Hz), 1.6-1.8 (2H, m) , 4.00 (2H, t, J=6.6Hz), 7.0-7.2 (2H, d, J=8.6Hz), 7.6-8.1 (10H, m) APCI-MASS : m/z = 417 (M+H) + Preparation 165 To a solution of Ethyl 4- [5- (4-n-pentyloxyphenyl) - isoxazol-3-yl]benzoate (6.33 g) in ethanol (60 ml) and tetrahydrofuran (90 ml) was added 2N sodium hydroxide aqueous solution (12.5 ml) at 80°C. The mixture was refluxed for 1 hour and poured into ice-water. The suspension was adjusted to pH 2.0 with IN HCl. The precipitate was collected by filtration, washed with water and dried to give 4-[5-(4-n- pentyloxyphenyl) isoxazol-3-yl]benzoic acid (5.80 g) . IR (KBr) : 2939, 2867, 1681, 1614, 1429, 1255, 1178, 821 cm "1 NMR (DMSO-dg, δ) : 0.91 (3H, t, J=7.1Hz), 1.3-1.5 (4H, m) , 1.6-1.8 (2H, m) , 4.04 (2H, t, J=6.5Hz), 7.11 (2H, d, J=8.9Hz), 7.54 (IH, s), 7.85 (2H, d, J=8.9Hz), 7.98 (2H, d, J=8.6Hz), 8.11 (2H, d, J=8.6Hz) APCI-MASS : m/z = 352 (M+H) * The following compounds (Preparations 166 to 170) were obtained according to a similar manner to that of Preparation _LQ. Preparation 166 5- [4- (4-n-Hexyloxyphenyl)piperazin-I-yl]picolic acid trihydrochloride IR (KBr) : 1689.3, 1577.5, 1511.9, 1241.9 cm "1 NMR (DMSO-dg, δ) : 0.88 (3H, t, J=6.5Hz), 1.15-1.5 (6H, m) , 1.6-1.8 (2H, m) , 3.1-3.25 (4H, ) , 3.45- 3.6 (4K, m) , 3.89 (2H, t, J=6.4Hz), 6.84 (2H, d, J=9.1Hz), 6.97 (2H, d, J=9.1Hz), 7.43 (IH, dd, J=8.8 and 3.0Hz), 7.90 (IH, dd, J=8.8 and 0.7Hz), 8.41 (IH, dd, J=3.0 and 0.7Hz) APCI-MASS : m/z = 384 (M + +H) Preparation 167 4- [4- (4-Phenylcyclohexyl)piperazin-l-yl]benzoic acid dihydrochloride IR (KBr) : 1700.9, 1606.4, 1220.7, 1180.2 cm "1 NMR (DMSO-dg, δ) : 1.4-1.85 (4H, m) , 1.9-2.05 (2H, m) , 2.2-2.4 (2H, m) , 3.1-3.5 (6H, m) , 3.5-3.7 (2H, m) , 3.9-4.2 (2H, ) , 7.06 (2H, d, J=8.8Hz), 7.1-7.4 (5H, m) , 7.83 (2H, d, J=8.8Hz) APCI-MASS : m/z = 365 (M + +H) Preparation 168 4- '4-Trans-n-pentylcyclohexyl)benzoic acid IR (KBr) : 1681.6, 1423.2, 1290.1 cm "1 NMR (CDC1 3 , δ) : 0.90 (3H, t, J=6.6Hz), 1.0-1.6 (13H, m) , 1.89 (4H, d, J=10Kz) , 2.54 (IH, t, J=12Hz), 7.30 (2H, d, J=8.3Hz), 8.03 (2H, d, J=8.3Hz) APCI-MASS : m/z = 274 (M + +H) Preparation 169 4- (4-Piperidinopiperidin-i-yl) benzoic acid IR (KBr) : 1710.6, 1403.9 cm "1 NMR (DMSO-dg, δ) : 1.6-2.1 (8H, m) , 2.17 (2H, d, J=12Hz), 2.7-3.05 (4H, m) , 3.2-3.5 (IH, m) , 3.35 (2H, d, J=12Hz), 4.05 (2H, d, J=13Hz), 7.01 (2H, d, J=8.9Hz), 7.77 (2H, d, J=8.9Hz), 10.84 (IH, s) APCI-MASS : m/z = 289 (M + +H) Preparation 170 3-Chloro-4- [4- (4-n-hexyloxypheny1)piperazin-l-yl]benzoic acid dihydrochloride IR (KBr) : 1712.5, 1598.7, 1513.8, 1251.6 cm "1 NMR (DMSO-dg, δ) : 0.88 (3H, t, J=6.6Hz), 1.2-1.5 (6H, m) , 1.6-1.8 (2H, m) , 3.4-3.6 (8H, m) , 3.98 (2H, t, J=6.4Hz), 7.02 (2H, d, J=9.0Hz), 7.32 (IH, d, J=8.1Hz), 7.60 (2H, d, J=9.0Hz), 7.89 (IH, d, J=8.1Hz), 8.02 (IH, s) APCI-MASS : m/z = 417 (M + +H) The following compounds (Preparations 171 to 175) were obtained according to a similar manner to that of Preparation 41- Preparation 171 Ethyl [4- (4-octylphenyl) -2, 3-dihydro-4H-l, 2, 4-triazole- 3-one-2-yl] acetate IR (KBr) : 2921.6, 1764.5, 1715, 1197.6 cm "1 NMR (CDC1 3 , δ) : 0.88 (3H, t, J=6.7Hz), 1.30 (3H, t, J=7.1Hz), 1.2-1.4 (10H, ) , 1.5-1.7 (2H, m) , 2.63 (2H, t, J=7.9Hz), 4.26 (2H, q, J=7.1Hz), 4.64 (2H, s), 7.28 (2H, d, J=8.4Hz), 7.44 (2H, d, J=8.4Hz), 7.71 (IH, s) Preparation 1 4-[4- (4-tert-Butoxycarbonylpiperazin-l-yl) henyl]-2- (4- methylpentyl)-2, 3-dihydro-4H-l,2, 4-triazol-3-one IR (KBr) : 1687.4 cm "1 NMR (CDC1 3 , δ) : 0.90 (6H, d, J=6.5Hz), 1.1-1.4 (2H, m) , 1.49 (9H, s), 1.4-1.9 (3H, m) , 3.16 (4H, t, J=4.9Hz), 3.59 (4H, t, J=4.9Hz), 3.82 (2H, t, J=7.3Hz), 6.98 (2H, d, J=9.0Hz), 7.41 (2H, d, J=9.0Hz), 7.61 (IH, s) Preparation 173 Methyl 6- (8-bromooctyloxy)-2-naphthoate IR (KBr) : 2933.2, 2856.1, 1720.2, 1294, 1209.1 cm "1 NMR (CDC1 3 , δ) : 1.3-1.6 (8H, m) , 1.75-2.0 (4H, m) , 3.42 (2H, t, J=6.8Hz), 3.96 (3H, s) , 4.09 (2H, t, J=6.5Hz), 7.14 (IH, d, J=1.7Hz), 7.19 (IH, dd, J=8.9 and 1.7Hz), 7.73 (IH, d, J=8.7Hz), 7.83 (IH, d, J=8.9Hz), 8.01 (IH, dd, J=8.7 and 1.7Hz), 8.51 (IH, d, J=1.7HZ) APCI-MASS : m/z = 393 (M + +H) Preparation 1 4-[4- (6-n-Propyloxyhexyloxy)phenyl]benzoic acid IR (KBr) : 2937, 2858, 1695, 1683, 1604, 1430, 1290, 1247, 1195 cm "1 NMR (DMSO-dg, δ) : 0.85 (3H, t, J=7.4Hz), 1.3-1.9 (10H, m) , 3.2-3.4 (4H, m) , 4.01 (2H, t, J=6.3Hz), 7.04 (2H, d, J=8.7Hz), 7.67 (2H, d, J=8.7Hz), 7.74 (2H, d, J=8.3Hz), 7.98 (2H, d, J=8.3Hz), 12.9 (IH, APCI-MASS : m/z = 357 (M+H + ; Preparation 175 4- [4- (6-Bromohexyloxy) phenyl]bromobenzene NMR (CDC1 3 , δ) : 1.40-1.65 (4H, m) , 1.70-2.00 (4H, m) , 3.43 (2H, t, J=6.7Hz), 4.00 (2H, t, J=6.4Hz), 6.95 (2K, d, J=8.8Hz), 7.30-7.60 (6H, m) The following compounds (Preparations 176 to 180) were obtained according to a similar manner to that of Preparation 4__- Preparation 176 4- [4- (4-n-Pentyloxyphenyl) piperazin-l-yl]benzoic acid dihydrochloride IR (KBr) : 1668.1, 1602.6, 1510.0, 1228.4 cm "1 NMR (DMSO-dg, δ) : 0.89 (3H, t, J=6.9Hz), 1.2-1.5 (5H, m) , 1.6-1.9 (2H, m) , 3.0-3.2 (4H, ) , 3.4-3.6 (4H, m) , 3.86 (2H, t, J=6.4Hz), 6.83 (2H, d, J=9Hz), 6.9-7.1 (4H, m) , 7.79 (2H, d, J=8.8Hz), 12.32 (IH, s) APCI-MASS : m/z = 369 (M+H + ) Preparation 177 4- [4- (4-n-Heptyloxyphenyl)piperazin-l-yl]benzoic acid dihydrochloride IR (KBr) : 1666.2, 16".6, 1511.9 cm -1 NMR (CDCI3, δ) : 0.8S H, t, J=6.9Hz), 1.2-2.0 (10H, m) , 3.1-3.3 (4H, π.. , 3.4-3.6 (4H, m) , 3.92 (2H, t, J=6.4Hz), 6.8-7.1 (6H, m) , 8.00 (2H, d, J=8.8Hz) Preparation 178 4- [4- [4- (4-Methylpentyloxy)phenyl]ρiperazin-l-yl]benzoic acid dihydrochloride IR (KBr) : 1668.1, 1602.6, 1510.0, 1236.1 cm "1 NMR (DMSO-dg, δ) : 0.89 (6H, d, J=6.5Hz), 1.2-1.4 (2H, m) , 1.4-1.8 (3H, m) , 3.0-3.2 (4H, m) , 3.3-3.5 (4H, ) , 3.87 (2H, t, J=6.3Hz), 6.83 (2H, d, J=9.0Hz), 6.9-7.1 (4H, ) , 7.79 (2H, d, J=8.8Hz), 12.33 (IH, s) APCI-MASS : m/z = 383 (M+H + ) Preparation 379 4- [4- [4- (8-Bromooctyloxy)phenyl]piperazin-1-yl]benzoic acid dihydrochloride IR (KBr) : 1670.1, 1602.6, 1511.9, 1234.2 cm "1 NMR (DMSO-dg, δ) : 1.2-1.5 (8H, m) , 1.6-1.9 (4H, m) , 3.0-3.2 (4H, m) , 3.2-3.5 (4H, m) , 3.52 (2H, t, J=6.7Hz), 3.88 (2H, t, J=6.4Hz), 6.83 (2H, d, J=9.1Hz), 6.94 (2H, d, J=9.1Hz), 7.02 (2H, d, J=8.9Hz), 7.79 (2H, d, J=8.9Hz) Preparation 180 3-Fluoro-4- [4- (4-n-hexyloxyphenyl)piperazin-l-yl]benzoic acid dihydrochloride IR (KBr) : 1673.9, 1511.9, 1240.0 cm "1 NMR (DMSO-dg, δ) : 0.88 (3H, t, J=6.5Hz), 1.2-1.5 (6H, m) , 1.6-1.8 (2H, m) , 3.0-3.5 (8H, m) , 3.88 (2H, t, J=6.4Hz), 6.7-7.2 (5H, m) , 7.4-7.8 (2H, ) , 12.82 (IH, s) APCI-MASS : m/z = 401 (M + +H) The following compound was obtained according to a similar manner to that of Preparation 46. Preparation 181 1- (4-Methoxycarbonylphenyl) -3- (4-n-hexyloxyphenyl) - propan-1, 3-dione IP (KBr) : 2956, 2927, 2856, 1722, 1511, 1284, 1108 cm "1 NMR (CDC1 3 , δ) : 0.92 (3H, t, J=6.4Hz), 1.2-2.0 (8H, m) , 3.96 (3H, s) , 4.04 (2H, t, J=6.5Hz), 6.82 (IH, s), 6.97 (2H, d, J=8.7Hz), 7.9-8.1 (4H, m) , 8.14 (2H, d, J=8.3Hz) APCI-MASS : m/z = 383 (M+H + ) The following c impounds (Preparations 182 to 185) were obtained according to a similar manner to that of Preparation 42. Preparation 182 Methyl 5- (4-octyloxyphenyl) -l-methylpyrazole-3- carboxylate IR (KBr pelet) : 2923, 1724, 1616, 1513, 1446, 1251, 1120 cm "1 NMR (CDCI3, δ) : 0.89 (3H, t, J=6.8Hz), 1.2-1.5 (10H, m) , 1.7-1.9 (2H, m) , 3.90 (3H, s), 3.98 (2H, t, J=6.6Hz), 4.20 (3H, s), 6.92 (2H, d, J=8.9Hz), 7.04 (IH, s), 7.89 (2H, d, J=8.9Hz) APCI-MASS : m/z = 345 (M+H + ) Preparation 183 Methyl 4- [5- (4-n-pentyloxyphenyl)pyrazol-3-yl]benzoate IR (KBr) : 3236, 2952, 2873, 1716, 1616, 1508, 1276, 1174, 1106 cm "1 NMR (CDCI3, δ) : 0.94 (3H, t, J=7.0Hz), 1.3-1.5 (4H, m) , 1.7-1.9 (2H, m) , 3.92 (3H, s) , 3.96 (2H, t, J=6.7Hz), 6.78 (IH, s) , 6.88 (2H, d, J=8.7Hz), 7.55 (2H, d, J=8.7Hz), 7.79 (2H, d, J=8.4Hz), 8.02 (2H, d, J=8.4Hz) APCI-MASS : m/z = 365 (M+H + ) Preparation 184 Methyl 5- (4-octyloxyphenyl) isoxazole-3-carboxylate IR (KBr pelet) : 2950, 2921, 1724, 1614, 1510, 1446, 1257, 1178, 1143, 1009 cm "1 NMR (CDCl 3 , δ) : 0.89 (3H, t, J=6.8Hz), 1.2-1.6 (10H, m) , 1.7-1.9 (2H, m) , 4.0-4.1 (5H, m) , 6.80 (IH, s), 6.98 (2H, dd, J=6.9 and 2.1Hz), 7.73 (2H, dd, J=6.9 and 2.1Hz) APCI-MASS : m/z = 332 (M+H + ) preparation 18 Methyl 4- [3- (4-n-hexyloxyphenyl)pyrazol-5-yl]benzoate IR (KBr) : 2952, 1716, 1616, 1508, 1276, 1106 cm "1 NMR (CDCI3, δ) : 0.91 (3H, t, J=6.3Hz), 1.2-1.6 (6H, m) , 1.7-1.9 (2H, ) , 3.8-4.0 (5H, m) , 6.76 (IH, s), 6.86 (2H, d, J=8.8Hz), 7.54 (2H, d, J=8.8Hz), 7.77 (2H, d, J=8.4Hz), 8.00 (2H, d, J=8.4Hz) APCI-MASS : m/z = 379 (M+H + ) Preparation 186 A suspension of 1- (4-n-Pentyloxyphenyl) -3- (4- ethoxycarbonylphenyl) -l-buten-3-one (74.43 g) and hydroxya ine hydrochloride (28.23 g) and potassium carbonate (56.11 g) in ethanol (400 ml) was refluxed for 4 hours. The mixture was diluted with ethyl acetate, washed with water (x 2), brine and dried over magnesium sulfate. The solvents were removed under reduced pressure to give crude oxime. To a solution of crude oxime in dichloroethane (500 ml) was added activated-manganese (IV) oxide (200 g) . The reaction mixture was refluxed for 2 hours and filtered. The residue was washed with dichloromethane. The solvents were removed under reduced pressure and the residue was triturated with acetonitrile. The solid was collected by filtration and dried to give ethyl 4- [5- (4-n-Pentyloxyphenyl) isoxazol-3- yl]benzoate (21.07 g) . IR (KBr) : 2945, 2872, 1717, 1615, 1508, 1280, 1108 cm - 1 NMR (CDCI , δ) : 0.95 (3H, t, J=6.9Hz), 1.3-1.9 (9H, m) , .01 (2H, t, J=6.5Hz), 4.41 (2H, q, J=7.1Hz), 6.74 (IH, s), 6.99 (2H, d, J=8.8Hz), 7.76 (2H, d, J=8.8Kz), 7.93 (2H, d, J=8.4Hz), 8.15 (2H, d, J=8.4Hz) APCI-MASS : m/z = 380 (M+H + ) The following compounds (Preparations 187 to 190) were obtained according to a similar manner to that of Preparation 4_L. Preparation 187 Methyl 6- [4- [4- (8-Methoxyoctyioxy)phenyl]piperazin-1- yl]nicotinate IR (KBr) : 2933, 2858, 1722, 1608, 1513, 1432, 1405, 1278, 1245 cm "1 NMR (CDC1 3 , δ) : 1.3-1.9 (12H, m) , 3.16 (4H, t, J=5.0Hz), 3.33 (3H, s), 3.36 (2H, t, J=6.5Hz), 3.8- 4.0 (9H, m) , 6.64 (IH, d, J=9.1Hz), 6.85 (2H, d, J=9.2Hz), 6.93 (2H, d, J=9.2Hz), 8.04 (IH, dd, J=9.1 and 2.2Hz), 8.81 (IH, d, J=2.2Hz) APCI-MASS : m/z = 456 (M+H + ) Preparation 188 4- [ - (5-Methoxypentyloxy)phenyl]bro obenzene IR (KBr) : 2940, 2856, 1604, 1479, 1286, 1255, 1124 cm "1 NMR (CDCI3, δ) : 1.5-1.9 (6H, m) , 3.34 (3H, s), 3.41 (2H, t, J=6.1Hz), 3.99 (2H, t, J=6.4Hz), 6.95 (2H, d, J=8.7Hz), 7.4-7.6 (6H, m) APCI-MASS : m/z = 349 (M+H + ) Preparation 189 Methy] 6- (8-methoxyoctyloxy) -2-naphthoate NMR (DMSO-dg, δ) : 1.2-1.6 (10H, m) , 1.7-1.9 (2H, m) , 3.20 (3H, s), 3.29 (2H, t, J=6.4Hz), 3.89 (3H, s), 4.11 (2H, t, J=6.4Hz), 7.24 (IK, dd, J=9.0 and 2.4Hz), 7.40 (IH, d, J=2.4Hz), 7.88 (IH, d, J=8.7Hz), 7.94 (IH, dd, J=8.7 and 1.5Hz), 8.03 (IK, d, J=9.0Hz), 8.55 (IH, d, J=1.5Hz) Preparation 190 4- [4- [4- (8-Methoxyoctyloxy)phenyl]piperazin-l-yl]benzoic acid dihydrochloride IR (KBr) : 1668.1, 1602.6, 1511.9, 1236.1 cm "1 NMR (DMSO-dg, δ) : 1.2-1.8 (12H, m) , 3.05-3.2 (4H, m) , 3.29 (2H, t, J=7.1Hz), 3.33 (3H, s), 3.4-3.55 (4H, m) , 3.88 (2H, t, J=6.4Hz), 6.82 (2H, d, J=9.0Hz), 6.94 (2H, d, J=9.0Hz), 7.02 (2H, d, J=8.8Hz), 7.79 (2H, d, J=8.8Hz), 12.31 (IH, s) The following compounds (Preparations 191 to 254) were obtained according to a similar manner to that of Preparation 4.9. Preparation 191 1- [4- [4- [4- [2- (4-Methylpentyl) -2, 3-dihydro-4H-l,2, 4- triazol-3-one-4-yl]phenyl]piperazin-l-yl]benzoyl] - benzotriazole 3-oxide IR (KBr) : 1766.5, 1693.2, 1600.6, 1519.6 cm -1 Preparation 192 1- [4- (4-Octylphenyl) -2, 3-dihydro-4H-l, 2, 4-triazol-3-one- 2-yl-acetyl]benzotriazole 3-oxide IR (KBr) : 2921.6, 1753.0, 1720.0, 1423.2 cm "1 NMR (CDC1 3 , δ) : 0.88 (3H, t, J=6.7Hz), 1.2-1.4 (10H, m) , 1.5-1.8 (2H, m) , 2.65 (2H, t, J=7.5Hz), 5.46 (2H, s), 7.30 (2H, d, J=8.5Hz), 7.48 (2H, d, J=8.5Hz), 7.62 (IH, t, J=8.3Hz), 7.80 (IH, s) , 7.82 96/11210 - 1 1 0 - ( IH, , J=8 . 3Hz ) , 8 . 05 ( IH, d, J=8 . 3Hz ) , 8 . 37 ( IH, d, J=8 . 3Hz ) Preparation 193 1- [4- [4- [4- (7-Methoxyheptyloxy)phenyl]piperazin-l- yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 1783.8, 1600.6, 1511.9, 1232.3, 1184.1 cm "1 NMR (CDC1 3 , δ) : 1.3-1.9 (10H, ) , 3.2-3.3 (4H, m) , 3.34 (3H, s), 3.38 (2H, t, J=6.4Hz), 3.5-3.7 (4H, ) , 3.92 (2H, t, J=6.5Hz), 6.87 (2H, d, J=9.2Hz), 6.95 (2H, d, J=9.2Hz), 7.00 (2H, d, J=9.0Hz), 7.3- 7.6 (3H, m) , 8.09 (IH, d, J=8.2Hz), 8.15 (2H, d, J=9.0Hz) Preparation 194 1- [4- [4- (4-n-Heptyloxyphenyl) piperazin-l- yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 1783.8, 1600.6, 1511.9, 1230.4, 1184.1 cm "1 NMR (CDCI3, δ) : 0.90 (3H, t, J=6.3Hz), 1.2-1.6 (8H, m) , 1.7-1.9 (2H, ) , 3.2-3.3 (4H, m) , 3.5-3.7 (4H, m) , 3.93 (2H, t, J=6.5Hz), 6.87 (2H, d, J=9.2H), 6.95 (2H, d, J=9.2Hz), 7.00 (2H, d, J=9.0Hz), 7.3- 7.7 (3H, m) , 8.09 (IH, d, J=8.2Hz), 8.15 (2H, d, J=9.0Hz) Preparation 195 l-[4-[4-[4- (4-MethyIpentyloxy)phenyljpiperazin-l-yl] - benzoyl]benzotriazole 3-oxide NMR (CDCI3, δ) : 0.92 (6H, d, J=6.6Hz), 1.2-1.4 (2H, m) , 1.5-1.9 (3H, m) , 3.1-3.3 (4H, ) , 3.5-3.7 (4H, ) , 3.92 (2H, t, J=6.6Hz), 6.87 (2H, d, J=9.3Hz), 6.96 (2H, d, J=9.3Hz), 7.01 (2H, d, J=9.0Hz), 7.4- 7.6 (3H, m) , 8.10 (IH, d, J=8.2Hz), 8.15 (2H, d, J=9.0Hz) - I l l - Preparation 196 1- [4- [4- (4-n-Pentyloxyphenyl) piperazin-l- yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 1787.7, 1600.6, 1511.9, 1232.3, 1184.1 cm "1 NMR (CDC1 3 , δ) : 0.93 (3H, t, J=6.9Hz), 1.3-1.6 (4H, m) , 1.7-1.9 (2H, m) , 3.1-3.4 (4H, m) , 3.5-3.8 (4H, m) , 3.93 (2H, t, J=6.6Hz), 6.87 (2H, d, J=9.2Hz), 6.92 (2H, d, J=9.2Hz), 7.01 (2H, d, J=9.1Hz), 7.4- 7.6 (3H, ) , 8.10 (IH, d, J=8.2Hz), 8.15 (2H, d, J=9.1Hz) Preparation 197 l-[4-[4-[8- (lH-Tetrazol-1-yl) octyloxy]phenyl]benzoyl] - benzotriazole 3-oxide and 1- [4- [4- [8- (2H-tetrazol-2-yl) octyloxy]phenyl]benzoyl] - benzotriazole 3-oxide IR (KBr) : 1778.0, 1602.6, 1189.9, 981.6 cm "1 NMR (CDCI3, δ) : 1.2-1.6 (8H, m) , 1.7-1.9 (2H, m) , 1.9-2.2 (2H, m) , 4.02 (2H, t, J=6.4Hz), 4.44 and 4.66 (2H, t, J=7.1Hz), 7.02 (2H, d, J=8.8Hz), 7.4- 7.6 (3H, m) , 7.63 (2H, d, J=8.8Hz), 7.79 (2H, d, J=8.6Hz), 8.12 (IH, d, J=8.2Hz), 8.32 (2H, d, J=8.6Hz), 8.51 and 8.60 (IH, s) Preparation 198 1- [4- [4- [8- (2, 6-Dimethylmorpholin-4-yl) octyloxy] - phenyl]benzoyl]benzotriazole 3-oxide IR (KBr) : 1778.0, 1600.6, 977.7 cm "1 NMR (CDCI3, δ) : 1.18 (6H, d, J=6.3Hz), 1.2-1.7 (10H, m) , 1.7-2.0 (4H, m) , 2.4-2.6 (2H, m) , 2.9-3.2 (2H, ) , 3.7-3.9 (2H, m) , 4.01 (2H, t, J=6.5Hz), 7.02 (2H, d, J=8.8Hz), 7.4-7.7 (3H, m) , 7.63 (2H, d, J=8 . 8Hz ) , 7 . 79 ( 2H, d, J=8 . 5Hz ) , 8 . 12 ( IH, d, J=8 . 1Hz ) , 8 . 32 ( 2H, d, J=8 . 5Hz ) Preparation 199 1- [6- [4- (4-Octyloxyphenyl)piperazin-l-yl] nicotinoyl] - benzotriazole 3-oxide IR (KBr pelet) : 2922, 2854, 1766, 1602, 1513, 1417, 1234, 1025, 950, 813 cm "1 NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.8H-: , 1.2-1.5 (10K, m) , 1.7-1.9 (2H, m) , 3.1-3.3 (4H, m) , 3.9-4.1 (6H, m) , 6.75 (IH, d, J=9.2Hz), 6.87 (2H, d, J=9.2Hz), 6.95 (2H, d, J=9.2Hz), 7.4-7.6 (3H, m) , 8.10 (IH, d, J=8.1Hz), 8.19 (IH, dd, J=9.2 and 2.4Hz), 9.04 (IH, d, J=2.4Hz) APCI-MASS : m/z = 529 (M+H + ) Preparation 200 1- [2- (4-Hexyloxyphenyl)benzoxazol-5-yl-carbonyl] - benzotriazole 3-oxide IR (KBr) : 2950, 1774, 1623, 1504, 1265, 1176 cm "1 NMR (CDCI3, δ) : 0.93 (3H, t, J=6.9Hz), 1.3-1.6 (6H, m) , 1.8-2.0 (2H, m) , 4.07 (2H, t, J=6.5Hz), 7.06 (2H, d, J=8.9Hz), 7.4-7.6 (3H, m) , 7.75 (IH, d, J=8.6Hz), 8.13 (IH, d, J=8.2Hz), 8.2-8.4 (3H, m) , 8.67 (IH, d, J=1.6Hz) APCI-MASS : m/z = 457 (M+H + ) Preparation 201 1- [4- [4- (4-n-Butyloxyphenyl)phenyl]benzoyl] - benzotriazole 3-oxide IR (KBr) : 2958, 2871, 1776, 1600, 1398, 1255, 1211, 1037 cm "1 NMR (CDC1 3 , δ) : 1.00 (3H, t, J=7.2Hz), 1.4-1.9 (4H, m) , 4.03 (2H, t, J=6.4Hz), 7.01 (2H, d, J=8.3Hz), 7.4-7.8 (9H, m) , 7.87 (2H, d, J=8.1Hz), 8.12 (IH, d, J=8.4Hz), 8.36 (2H, d, J= n 9Hz; APCI-MASS : m/z = 464 (M+H) + Preparation 202 1- [2- (4-Heptyloxyphenyl)pyridin-5-yl- carbonyl]benzotriazole 3-oxide IR (KBr) : 2944, 2867, 1793, 1770, 1589, 1471, 1321, 1093 cm "1 NMR (CDC1 3 , δ) : 0.91 (3H, t, J=6.7Hz), 1.2-1.6 (8H, m) , 1.7-1.9 (2H, m) , 4.05 (2H, t, J=6.5Hz), 7.04 (2H, d, J=8.0Hz), 7.4-7.6 (3H, ) , 7.91 (IH, d, J=8.5Hz), 8.1-8.2 (3K, ) , 8.51 (IH, dd, J=8.5 and 2.3Hz), 9.47 (IH, d, J=2.3Hz) APCI-MASS : m/z = 431 (M+H + ) Preparation 203 1- [2- (2-Octyloxypyridin-5-yl)benzoxazol-5-yl- carbonyljbenzotriazole 3-oxide IR (KBr pelet) : 2925, 2854, 1787, 1623, 1479, 1263, 989 cm "1 NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.8Hz), 1.2-1.5 (10H, m) , 1.8-1.9 (2K, m) , 4.42 (2H, t, J=6.7Hz), 6.91 (IH, d, J=8.7Hz), 6.4-6.6 (3H, ) , 7.79 (IH, d, J=8.6Hz), 8.13 (IH, d, J=8.2Hz), 8.32 (IH, dd, J=8.6 and 1.7Hz), 8.41 (IH, dd, J=8.7 and 2.4Hz), 8.70 (IH, d, J=1.4Hz), 9.07 (IH, d, J=1.9Hz) APCI-MASS : m/z = 486 (M+H + ) Preparation 04 l-[2-[4- (4-Hexylphenyl)phenyl]benzoxazol-5-yl- carbonyl]benzotriazole 3-oxide IR (KBr) : 2927, 2854, 1785, 1621, 1490, 1261, 1166, 1052 cm "1 NMR (CDC1 3 , δ) : 0.90 (3H, t, J=6.5Hz), 1.2-1.8 (8H, m) , 2.68 (2H, t, J=7.9Hz), 7.31 (2H, d, J=8.2Hz), 7.4-7.7 (5H, m) , 7.79-7.81 (3H, m) , 8.13 (IH, d, J=8.3Hz), 8.3-8.4 (3H, ) , 8.73 (IH, d, J=1.3Hz) APCI-MASS : m/z = 517 (M+H "1" ) Preparation 205 1- [2- [4- (4-n-Butyloxyphenyl)phenyl]pyridin-5-yl- carbonyl]benzotriazole 3-oxide IR (KBr) : 2956, 2933, 2871, 1774, 1650, 1591, 1471, 1251 cm "1 NMR (CDC1 3 , δ) : 1.00 (3H, t, J=7.2Hz), 1.5-1.9 (4H, ) , 4.03 (2H, t, J=6.4Hz), 7.02 (2H, d, J=8.6Hz), 7.4-7.6 (3H, m) , 7.54 (2H, d, J=7.3Hz), 7.62 (2K, d, J=8.5Hz,, 8.02 (IH, d, J=8.3Hz), 8.13 (IH, d, J=8.2Hz), 8.21 (2H, d, J=7.9Hz), 8.57 (IH, dd, J=8.3 and 2.0Hz), 9.54 (IH, d, J=2.0Hz) APCI-MASS : m/z = 465 (M-r-H) " " Preparation 206 1- [4- [4- (5-Phenoxypentyloxy)phenyl]benzoyl] - benzotriazole 3-oxide IR (KBr) : 2944, 2869, 1770, 1600, 1494, 1249, 1189 cm "1 NMR (CDC1 3 , δ) : 1.6-1.8 (2H, m) , 1.8-2.0 (4H, m) , 4.01 (2H, t, J=6.3Hz), 4.07 (2H, t, J=6.2Hz), 6.91 (2H, d, J=8.9Hz), 7.04 (2H, d, J=8.7Hz), 7.3-7.6 (4H, m) , 7.63 (2H, d, J=8.6Hz), 7.78 (2H, d, J=8.4Hz), 8.12 (IH, d, J=8.1Hz), 8.32 (2H, d, J=8.4Hz) APCI-MASS : m/z = 494 (M+H) + Preparation 207 1- [4- [5- (4-Hexyloxyphenyl) -1, 3, 4-oxadiazol-2- yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 2956, 2921, 2856, 1778, 1612, 1496, 1261, 1232, 1025 cm "1 NMR (CDC1 3 , δ) : 0.92 (3H, t, J=6.7Hz), 1.3-1.6 (6H, m), 1.8-2.0 (2H, m) , 4.05 (2H, t, J=6.5Hz), 7.05 (2ή ' , d, J=8.7Hz), 7.4-7.6 (3H, m) , 8.10 (2H, d, J=8.7Hz), 8.13 (IH, d, J=7.4Hz), 8.37 (2H, d, J=8.5Hz), 8.45 (2H, d, J=8.5Hz) APCI-MASS : m/z = 484 (M+H) + Preparation 208 1- [4- [5- (4-n-Hexyloxyphenyl) -1, 3, 4-thiadiazol-2- yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 2952, 2873, 1774, 1602, 1261, 1230, 1176 cm " - NMR (CDC1 3 , δ) : 0.93 (3H, t, J=6.8Hz), 1.3-2.0 (8H, m) , 4.04 (2H, t, J=6.5Hz), 7.02 (2H, d, J=8.7Hz), 7.4-7.7 (3H, m) , 7.98 (2H, d, J=8.7Hz), 8.13 (IH, d, J=8.7Hz), 8.25 (2H, d, J=8.3Hz), 8.41 (2H, d, J=8.3Hz) APCI-MASS : m/z = 500 (M+H) + Preparation 209 1- [5- (4-Octyloxyphenyl) -l-methylpyrazol-3-yl- carbonyl]benzotriazole 3-oxide IR (KBr pelet) : 2939, 2852, 1776, 1687, 1612, 1448, 1249, 995 cm "1 NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.7Hz), 1.3-1.5 (10H, m) , 1.7-1.9 (2H, m) , 4.01 (2H, t, J=6.5Hz), 4.25 (3H, s), 6.97 (2H, d, J=6.8Hz), 7.4-7.7 (4H, m) , 7.78 (2H, d, J=6.8Hz), 8.14 (IH, d, J=8.0Hz) APCI-MASS : m/z = 448 (M+H + ) Preparation 210 1- [4- [5- (4-n-Pentyloxyphenyl)pyrazol-3- yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 3251, 2956, 2869, 1780, 1612, 1506, 1232, 985 cm "1 NMR (CDCI3, δ) : 0.95 (3H, t, J=6.9Hz), 1.3-1.6 (4H, m) , 1.7-2.0 (2H, m) , 4.01 (2H, t, J=6.6Hz), 6.90 (IH, s), 6.99 (2H, d, J=8.7Hz), 7.4-7.6 (5H, m) , 8.0-8.2 (3H, m) , 8.33 (2H, d, J=8.4Hz) APCI-MASS : m/z = 468 (M+H + ) Preparation 211 1- [5- [4- (4-n-Butoxyphenyl) phenyl] furan-2-yl- carbonyl]benzotriazole 3-oxide IR (KBr) : 2958, 2871, 1781, 1678, 1603, 1535, 1479, 1265 cm "1 NMR (CDCI3, δ) : 1.00 (3H, t, J=7.3Hz), 1.4-1.9 (4H, m) , 4.02 (2H, t, J=6.4Hz), 6.9-7.1 (3H, m) , 7.4-8.2 (11H, m) APCI-MASS : m/z = 351 ( Methyl ester) Preparation 212 1- (3- (S) -Hydroxy-2-benzylhexadecanoyl)benzotriazole 3- oxide IR (Neat) : 2854.1, 1814.7, 1459.8, 742.5 cm "1 Preparation 213 1- (3- (R) -Benzyloxycarboxylamino-18-methoxyoctadecanoyl) - benzotriazole 3-oxide IR (KBr) : 1805.0, 1729.8, 1695.1 cm "1 NMR (DMSO-dg, δ) : 1.1-1.65 (30H, m) , 3.20 (3H, s) , 3.28 (2H, t, J=6.5Hz), 4.01 (IH, ) , 5.06 (2H, s), 7.32 (5H, m) , 7.4-7.8 (3H, m) , 8.12 (IH, d, J=7Hz) Preparation 214 1- (3- (S)-Hydroxyhexadecanoyl)benzotriazole 3-oxide IR (KBr) : 1710.6, 1498.4, 1429.0, 771.4 cm "1 NMR (CDCI3, δ) : 0.88 (3H, t, J=6.4Hz), 1.2-1.7 (24H, m) , 2.00 (IH, s), 3.1-3.5 (2H, m), 4.30 (IH, m) , 7.59 (IH, t, J=7.8Hz), 7.81 (IH, t, J=7.8Hz), 8.02 ( IH, d, J=8 . 3Hz ) , 8 . 42 1 ( 1H, d, J=8 . 3Hz ) Preparation 215 1- (3-MethyI-2-tridecenoyl)benzotriazole 3-oxide IR (KBr) : 2927.4, 1791.5, 1633.4, 1081.9 cm -1 NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.3Hz), 1.1-1.7 (20H, ) , 2.25 (3H, s), 6.08 (IH, s) , 7.3-7.6 (3H, m) , 8.06 (IH, d, J=8.2Hz) Preparation 216 l-[4-[4-[4- (8-Methoxyoctyloxy)phenyl]piperazin-l- yl1benzoyl]benzotriazole 3-o ide IR (KBr) : 1780.0, 1600.6, 1511.9, 1234.2, 1184.1 cm "1 NMR (CDCI3, δ) : 1.3-1.9 (12H, m) , 3.24 (4H, t, J=5.0Hz), 3 . 33 (3H, s), 3.37 (2H, t, J=6.8Hz), 3.62 (4H, t, J=5.0Hz), 3.92 (2H, t, J=6.5Hz), 6.8-7.1 (6H, m) , 7.35-7.65 (3H, m) , 8.09 (IH, d, J=8.2Hz), 8.15 (2H, d, J=9.0Hz) Preparation 217 1- [3-Fluoro-4- [4- (4-n-hexyloxyphenyl)piperazin-l- yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 1778.0 cm "1 Preparation 218 1- [3-Chloro-4- [4- (4-n-hexyloxyphenyl)piperazin-l- yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 1778.0, 1594.8, 1511.9, 1218.8 cm -1 NMR (CDC1 3 , δ) : 0.91 (3H, t, J=6.5Hz), 1.2-1.6 (6H, m) , 1.6-1.9 (2H, m) , 3.29 (4H, t, J=3.6Hz), 3.44 (4H, t, J=3.6Hz), 3.93 (2H, t, J=6.5Hz), 6.87 (2H, d, J=9.2Hz), 6.97 (2H, d, J=9.2Hz), 7.19 (IH, d, J=8.6Hz), 7.4-7.7 (3H, m) , 8.10 (IH, d, J=6.4Hz), 8.14 (IH, dd, J=8.6 and 2.1Hz), 8.27 (IH, d, J=2.1Hz) APCI-MASS : m/z = 534 (M + +H) Preparation 219 1- [4- (4-Piperidinopiperidin-l-yl)benzoyl]benzotriazole 3-oxide IR (KBr) : 1758.8, 1602.6, 1186.0 cm "1 NMR (CDC1 3 , δ) : 1.35-1.8 (8H, m) , 1.96 (2H, d, J=13Hz), 2.45-2.7 (5H, m) , 2.97 (2H, td, J=12.8 and 2.6Hz), 4.04 (2H, d, J=13Hz) , 6.93 (2K, d, J=9.2Hz), 7.35-7.6 (3H, m) , 8.1-8.4 (3H, m) Preparation 220 I- [3- [4- (4-n-Hexyloxyphenyl)piperazin-l-yl]pyridazin-6- yl-carbonyl]benzotriazole 3-oxide IR (KBr) : 1787.7, 1585.2, 1511.9, 1240.0 cm "1 Preparation 221 1- [5- [4- (4-n-Hexyloxyphenyl) piperazin-l-yl]picolinoyl] - benzotriazole 3-oxide IR (KBr) : 1766.5, 1575.6, 1511.9, 1232.3 cm "1 NMR (CDC1 3 , δ) : 0.91 (3H, t, J=6.5Hz), 1.2-1.6 (6H, m) , 1.65-1.9 (2H, m) , 3.27 (4H, t, J=5.1Hz), 3.66 (4H, t, J=5.1Hz), 3.93 (2H, t, J=6.5Hz), 6.88 (2H, d, J=9.2Hz), 6.95 (2H, d, J=9.2Hz), 7.25 (IH, dd, J=7.6 and 2.9Hz), 7.35-7.6 (3H, ) , 8.09 (IH, d, J=8.2Hz), 8.18 (IH, d, J=8.9Hz), 8.52 (IH, d, J=2.9Hz) APCI-MASS : m/z = 501 (M + +H) Preparation 222 1- [4- [4- (4-Cyclohexylphenyl)piperazin-l-yl]benzoyl]- benzotriazole 3-oxide IR (KBr) : 1770.3, 1602.6, 1515.8, 1232.3, 1186.0 cm "1 NMR (CDC1 3 , δ) : 1.15-1.5 (6H, m) , 1.65-2.0 (4H, m) , 2.45 (IH, m) , 3.33 (4H, t, J=5.1Hz), 3.62 (4H, t, J=5.1Hz), 6.92 (2H, d, J=8.7Hz), 6.99 (2H, d, J=9.2Hz), 7.16 (2H, d, J=8.7Hz), 7.35-7.65 (3H, m) , 8.09 (IH, d, J=8.2Hz), 8.15 (2H, d, J=9.2Hz) Preparation 223 1- [4- [4- (4-n-Hexylphenyl)piperazin-l-yl]benzoyl]- benzotriazole 3-oxide IR (KBr) : 1768.4, 1602.6, 1515.8, 1230.4, 1184.1 cm -1 NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.5Hz), 1.2-1.45 (6K, m) , 1.5-1.7 (2H, m) , 2.55 (2H, t, J=7.6Hz), 3.2-3.4 (4H, ) , 3.5-3.7 (4H, ) , 6.91 (2H, d, J=8.6Hz), 7.00 (2H, d, J=9.1Hz), 7.13 (2H, d, J=8.5Hz), 7.35- 7.6 (3H, m) , 8.09 (IH, d, J=8.2Hz), 8.15 (2H, d, J=9.1Hz) Preparation 224 1- [4- [4- (4-Phenylcyclohexyl)piperazin-1- yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 1780.0, 1762.6, 1602.6, 1234.2, 1182.2 cm "1 NMR (CDCI3, δ) : 1.3-1.7 (4H, m) , 1.95-2.15 (4H, m) , 2.35-2.6 (2H, m) , 2.79 (4H, t, J=5.0Hz), 3.49 (4K, t, J=5.0Hz), 6.95 (2H, d, J=9.0Hz), 7.1-7.35 (5H, m) , 7.35-7.6 (3H, m) , 8.08 (IH, d, J=7.1Hz), 8.12 (2H, d, J=9.0Hz) Preparation 225 1- [4- [4- [1- (4-n-Hexyloxyphenyl)piperidin-4-yl]piperazin- 1-yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 1768.4, 1602.6, 1511.9, 1234.2 cm "1 NMR (CDCI3, δ) : 0.90 (3H, t, J=6.5Hz), 1.2-1.55 (6H, m) , 1.6-1.9 (4H, ) , 1.96 (2H, d, J=llHz) , 2.44 (IH, m) , 2.64 (2H, d, J=l.lHz), 2.77 (4H, t, J=5.0Hz), 3.48 (4H, t, J=5.0Hz), 3.59 (2H, d, J=llHz), 3.91 (2H, t, J=6.5Hz), 6.7-7.05 (6H, ) , 7.35-7.6 (3H, ) , 8.08 (IH, d, J=6.9Hz), 8.12 (2H, d, J=7 . 7Hz ) Preparation 226 2- [4- (4-Trans-n-pentylcyclohexyl) benzoyl]benzotriazole 3-oxide IR (KBr) : 1799.3, 1778.0, 1608.3, 1228.4, 977.7 cm "1 NMR (CDC1 3 , δ) : 0.91 (3H, t, J=6.6Hz), 1.0-1.7 (13H, m) , 1.93 (4H, d, J=9.8Hz), 2.62 (IH, t, J=12Hz), 7.35-7.6 (5H, m) , 8.09 (IH, d, J=7.9Hz), 8.19 (2H, d, J=8.4Hz) Preparation 7 1- [6- (8-Methoxyoctyloxy) -2-naphthoyl]benzotriazole 3- oxide IR (KBr) : 2931.3, 2856.1, 1778.0, 1623.8 cm "1 Preparation 228 l-(E)-[3-[4-[4- (7-Fluoroheptyloxy)phenyl]phenyl]- acryloyl]benzotriazole 3-oxide IR (KBr) : 3070.1, 2935.1, 2859.9, 1700.9, 1619.9, 1596.8 cm "1 NMR (CDCI3, δ) : 1.30-2.00 (10H, m) , 4.02 (2H, t, J=6.4Hz), 4.45 (2H, dt, J=47.5 and 6.2Hz), 6.70- 8.65 (14H, ) Preparation 229 1- (6-Heptylnaphthalene-2-carbonyl) enzotriazole 3-oxide NMR (DMSO-dg, δ) : 0.75-0.93 (3H, m) , 1.10-1.45 (8H, m) , 1.55-1.80 (2H, m) , 2.68-2.90 (2H, m) , 7.35-9.06 (10H, m) APCI-MASS : m/z = 388 (M + +l) Preparation 230 l-(E)-[3-[4-[4- (8-Methoxyoctyloxy)phenyl]phenyl] - acryloyl]benzotriazole 3-oxide Preparation 231 l-(E)-[3-[4-[4- (5-Hexenyloxy)phenyl]phenylJacryloyl] - benzotriazole 3-oxide IR (KBr) : 3072.0, 3033.5, 2939.0, 2865.7, 1780.0, 1693.2, 1619.9, 1596.8 cm "1 NMR (DMSO-dg, δ) : 1.43-1.66 (2H, m) , 1.66-1.90 (2H, m) , 2.02-2.23 (2H, m) , 3.90-4.16 (2H, m) , 4.90-5.13 (2H, m) , 5.72-6.00 (IH, m) , 6.93-8.30 (14H, m) APCI-MASS : m/z = 337 (Methyl ester, M + +l) preparation 23 1-(E) -[3- [4- [4- (4-Methylpentyloxy)phenyl]phenyl]- acryloyl jbenzotriazole 3-oxide IR (KBr) : 3072.0, 3033.5, 2952.5, 2869.6, 1780.0, 1693.2, 1618.0, 1598.7 cm "1 NMR (DMSO-dg, δ) : 0.90 (6H, d, J=6.5Hz), 1.20-1.40 (2H, ) , 1.50-1.90 (3H, m) , 3.90-4.10 (2H, m) , 6.40-8.30 (14H, m) APCI-MASS : m/z = 442 (M + +l) Preparation 233 1- (E) - [3- [4- [4- (6-Fluorohexyloxy) henyl]phenyl]- acryloyl]benzotriazole 3-oxide IR (KBr) : 3074.0, 3033.5, 2939.0, 2865.7, 1780.0, 1697.1, 1598.7 cm "1 NMR (DMSO-dg, δ) : 1.25-1.83 (6H, m) , 4.04 (2H, t, J=6.5Hz), 4.45 (2H, dt, J=47.5 and 6.5Hz), 6.9-8.3 (14H, m) APCI-MASS : m/z = 460 (M + +l) Preparation 234 1- (E) - [3-[4- [4- (6-Methoxyhexyloxy)phenyl]phenyl]- acryloyljbenzotriazole 3-oxide NMR (DMSO-dg, δ) : 1.30-1.65 (6H, ) , 1.65-1.90 (2H, m), 3.22 (3H, s) , 3.22-3.40 (2H, m) , 4.02 (2H, t, J= 6 . 5Hz ) , 6 . 5- 8 . 3 ( 14H , m) Preparation 235 1- [4- [3- (4-n-Hexyloxyphenyl)pyrazol-5- yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 2935, 1780, 1610, 1506 1249, 1232, 1178, 1087 cm "1 NMR (CDC1 3 , δ) : 0.91 (3H, d, J=6.4Hz), 1.2-1.6 (6H, ir), 1.7-1.9 (2H, m) , 3.98 (2K, t, J=6.5Hz), 6.8-7.0 5H, m) , 7.4-7.6 (5H, m) , 8.00 (2H, d, J=8.4Hz), 8.10 (IK, d, J=8.1Hz), 8.28 (IH, d, J=8.4Hz) APCI-MASS : m/z = 482 (M+H + ) Preparation 236 1- [4- [4- [4- (6-Methoxyhexyloxy)phenyl]phenyl]benzoyl] - benzotriazole 3-oxide IR (KBr) : 2935, 2858, 1774, 1600, 1490, 1257, 1211 cm "1 NMR (CDCI3, δ) : 1.4-1.9 (8H, m) , 3.35 (3H, s) , 3.40 (2H, t, J=6.3Hz), 4.02 (21H, t, J=6.4Hz), 7.00 (2H, d, J=8.7Hz), 7.4-7.8 (7H, m) , 7.87 (2H, d, J=8.4Hz), 8.12 (IH, d, J=8.2Hz), 8.36 (2H, d, J=8.4Hz) APCI-MASS : m/z = 522 (M+H + ) Preparation 237 1- [4- [5- [4- (8-Methoxyoctyloxy)phenyl] -1, 3, 4-thiadiazol- 2-yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 2929, 2854, 1776, 1602, 1469, 12 r' cm "1 NMR (CDCI3, δ) : 1.2-1.6 (10H, m) , l.~-1.9 (2H, m) , 3.33 (3H, s), 3.37 (2H, d, J=6.4Hz), 4.03 (2H, d, J=6.5Hz), 7.00 (2H, d, J=8.9Hz), 7.4-7.6 (3H, m) , 7.97 (2H, d, J=8.9Hz), 8.12 (IH, d, J=8.2Hz), 8.23 (2H, d, J=8.7Hz), 8.39 (2H, d, J=8.7Hz) APCI-MASS : m/z = 558 (M+H + ) Preparation 238 1- [4- (4-n-Butoxyphenyl) cinnamoyl]benzotriazole 3-oxide IR (KBr) : 2952, 2867, 1778, 1598, 1496, 1249, 1186 cm "1 NMR (CDC1 3 , δ) : 0.99 (3H, t, J=7.3Hz), 1.55 (2H, tq, J=7.0 and 7.3Hz), 1.78 (2H, tt, J=7.0 and 6.4Hz), 4.02 (2H, t, J=6.4Hz), 6.75 (IH, d, J=l6.0Hz), 7.00 (2H, d, J=8.7Hz), 7.4-8.2 (9H, m) APCI-MASS : m/z = 414 (M+H + ) Preparation 239 1- [4- [5- (4-Cyclohexylphenyl ) -1, 3, 4-thiadiazol-2- yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 2925, 2850, 1778, 1230, 989 cm "1 NMR (CDC1 3 , δ) : 1.2-1.6 (5H, m) , 1.7-2.0 (5H, ) , 2.5-2.7 (IH, m) , 7.37 (2H, d, J=8.3Hz), 7.4-7.6 (3H, m) , 7.97 (2H, d, J=8.3Hz), 8.13 (IH, d, J=8.2Hz), 8.26 (2H, d, J=8.6Hz), 8.42 (2H, d, J=8.6Hz) APCI-MASS : m/z = 482 (M+H) + Preparation 240 1- [4- [5- [4- (4-n-Propyloxyphenyl)phenyl] -1, 3, 4-oxadiazol- 2-yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 1778, 1604, 1488, 1249, 1232, 998 cm "1 NMR (CDCI3, δ) : 1.07 (3H, t, J=7.4Hz), 1.85 (2H, tq, J=6.5 and 7.4Hz), 7.02 (2H, d, J=8.8Hz), 7.4-7.7 (3H, m) , 7.61 (2H, d, J=8.8Hz), 7.75 (2H, d, J=8.5Hz), 8.14 (IH, d, J=8.2Hz), 8.22 (2H, d, J=8.5Hz), 8.40 (2H, d, J=8.8Hz), 8.48 (2H, d, J=8.8Hz) APCI-MASS : m/z = 518 (M+H) + Preparation 241 l-[4- (5-n-Nonyl-l,3,4-oxadiazol-2-yl)benzoyl]- benzotriazole 3-oxide IR (KBr) : 2919, 2850, 1780, 1565, 1415, 1251 cm "1 NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.7Hz), 1.2-1.6 (12H, m) , 1.8-2.0 (2H, m) , 2.98 (2H, t, J=7.7Hz), 7.4-7.6 (3H, m) , 8.12 (IH, d, J=9.0Hz), 8.28 (2H, d, J=8.7Hz), 8.42 (2H, d, J=8.7Hz) APCI-MASS : m/z = 434 (M+H + ) Preparation 242 1- [4- [3- (4-n-Hexyloxyphenyl) -1, 2, 4-oxadiazol-5-yl] - benzoyl]benzotriazole 3-oxide IR (KBr) : 2946, 2869, 1780, 1251, 1230, 1001 cm "1 NMR (CDCI3, δ) : 0.92 (3H, t, J=6.8Hz), 1.3-1.6 (6H, m) , 1.8-1.9 (2H, m) , 4.04 (2H, t, J=6.5Hz), 7.03 (2H, d, J=8.9Hz), 7.4-7.6 (3K, m) , 8.0-8.2 (3H, ) , 8.46 (4H, s) APCI-MASS : m/z = 484 (M+H + ) Preparation 243 1- [4- [5- (4-n-Octyloxyphenyl) -1, 3, 4-thiadiazol-2-yl] - benzoyl]benzotriazole 3-oxide IR (KBr) : 2925, 2856, 1774, 1602, 1259, 1232, 989 cm "1 NMR (CDC1 3 , δ) : 0.90 (3H, t, J=6.7Hz), 1.1-1.6 (10H, m) , 1.7-1.9 (2H, ) , 4.04 (2H, t, J=6.5Hz), 7.01 (2H, d, J=8.9Hz), 7.4-7.6 (3H, m) , 7.97 (2H, d, J=8.8Hz), 8.12 (IH, d, J=8.2Hz), 8.24 (2H, d, J=8.6Hz), 8.40 (2H, d, J=8.6Hz) APCI-MASS : m/z = 528 (M+H + ) Preparation 244 1- [4- [5- (4-Trans-n-pentylcyclohexyl) -1, 3, 4-thiadiazol-2- yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 2952, 2919, 2848, 1785, 1444, 1226, 991 c "1 NMR (CDCI3, δ) : 0.90 (3H, t, J=6.9Hz), 1.0-1.7 (13H, m) , 1.94 (2H, d, J=12.0Hz), 2.27 (2H, d, J=12.0Hz), 3.19 (IH, tt, J=12.0 and 3.6Hz), 7.4-7.6 (3H, m) , 8.12 (IH, d, J=8.0Hz), 8.19 (2H, d, J=8.6Hz), 8.38 (2H, d, J=8.6Hz) APCI-MASS : m/z = 476 (M+H + ) Preparation 245 1- [4- [3- (4-n-Pentyloxyphenyl) isoxazol-5- yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 2948, 2867, 1776, 1610, 1436, 1253, 1002 cm "1 NMR (CDC1 3 , δ) : 0.95 (3H, t, J=7.1Hz), 1.2-1.6 (4H, m) , 1.7-1.9 (2H, m) , 4.02 (2H, t, J=6.5Hz), 7.0-7.1 (3H, m) , 7.4-7.6 (3H, m) , 7.81 (2H, d, J=8.8Hz), 8.06 (2H, d, J=8.6Hz), 8.12 (IH, d, J=8.0Hz), 8.39 (2H, d, J=8.6Hz) APCI-MASS : m/z = 469 (M+H + ) Preparation 246 1- [4- [5- [4- (8-Methoxyoctyloxy)phenyl]-1, 3, 4-oxadiazol-2- yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 2923, 2854, 1787, 1608, 1494, 1255, 1228, 993 cm "1 NMR (CDCI3, δ) : 1.2-1.6 (10H, m) , 1.7-1.9 (2H, m) , 3.34 (3H, s), 3.38 (2H, t, J=6.4Hz), 4.05 (2H, t, J=6.5Hz), 7.04 (2H, d, J=8.8Hz), 7.4-7.6 (3H, s), 8.1-8.2 (3H, s), 8.36 (2H, d, J=8.7Hz), 8.45 (2H, d, J=8.7Hz) APCI-MASS : m/z = 542 (M+H + ) Preparation 247 1- [4- [4- (6-Phenylpyridazin-3-yl-oxy]phenyl]benzoyl]- benzotriazole 3-oxide IR (KBr) : 1783, 1604, 1423, 1284, 985 cm "1 NMR (CDCI3, δ) : 7.2-8.2 (15H, m) , 8.12 (2H, d, J=8.3Hz), 8.36 (2H, d, J=8.4Hz) APCI-MASS : m/z = 486 (M + +l) Preparation 248 1- [4- [5- (4-n-0ctyloxyphenyi) -1, 3, 4-oxadiazol-2- yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 2925, 2854, 1780, 1610, 1496, 1257, 1228, 1180 cm "1 NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.8Hz), 1.2-2.0 (12H, m) , 4.05 (2H, t, J=6.5Hz), 7.05 (2H, d, J=8.7Hz), 7.4-7.6 (3K, m) , 8.0-8.2 (3K, m) , 8.37 (2H, d, J=8.6Hz), 8.45 (2H, d, J=8.6Hz) APCI-MASS : m/z = 512 (M+H + ) Preparation 249 1- [4- [2- (4-n-Hexyloxyphenyl) pyrimidin-6-yl]benzoyl] - benzotriazole 3-oxide IR (KBr) : 2948, 2861, 1780, 1552, 1413, 1378, 987 cm "1 NMR (CDCI3, δ) : 0.92 (3H, t, J=6.8Hz), 1.2-1.6 (6H, m) , 1.8-2.0 (2H, m) , 4.06 (2H, t, J=6.5Hz), 7.04 (2H, d, J=9.0Hz) ,7.4-7.6 (3H, m) , 7.64 (IH, d, J=5.2Hz), 8.13 (IH, d, J=8.2Hz), 8.44 (4H, s), 8.55 (2H, d, J=9.0Hz), 8.90 (IH, d, J=5.2Hz) APCI-MASS : m/z = 494 (M+H + ) Preparation 250 1- [4- [4- [8- (2-Ethoxyethoxy) octyloxy]phenyl]benzoyl] - benzotriazole 3-oxide IR (KBr) : 2933, 2861, 1778, 1598, 1247, 1186, 977 cm "1 NMR (CDCI3, δ) : 1.22 (3H, t, J=7.0Hz), 1.3-2.0 (14H, m) , 3.4-3.6 (6H, m) , 4.02 (2H, t, J=6.5Hz), 7.02 (2H, d, J=8.8Hz), 7.4-7.6 (3H, m) , 7.62 (2H, d, J=8.8Hz), 7.78 (2H, d, J=8.6Hz), 8.10 (IH, d, J=8.9Hz), 8.31 (2H, d, J=8.6Hz) APCI-MASS : m/z = 532 (M+H + ) Preparation 251 1- [4- [4- [7- (Piperidin-1-yl-carbonyl)heptyloxy]phenyl]- benzoyl]benzotriazole 3-oxide IR (KBr) : 2935, 2856, 1774, 1631, 1598, 1255, 1191 cm -1 NMR (CDC1 3 , δ) : 1.3-2.0 (16H, m) , 2.37 (2H, t, J=7.6Hz), 3.48 (4H, s) , 4.02 (2H, t, J=6.4Hz), 7.02 (2H, d, J=8.6Hz), 7.4-7.6 (3H, m) , 7.63 (2H, d, J=8.6Hz), 7.78 (2H, d, J=8.3Hz), 8.11 (IH, d, J=8.1Hz), 8.31 (2H, d, J=8.3Hz) APCI-MASS : m/z = 541 (M+H + ) preparation 252 1- [6- [4- (4-n-Heptyloxyphenyl)piperazin-l-yl]nicotinoyl] - benzotriazole 3-oxide IR (KBr) : 2929, 2856, 1762, 1604, 1510, 1240 cm "1 NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.7Hz), 1.2-1.9 (10H, m) , 3.20 (4H, t, J=5.0Hz), 3.8-4.0 (6H, m) , 6.75 (IH, d, J=9.5Hz), 6.86 (2H, d, J=9.3Hz), 6.95 (2H, d, J=9.3Hz), 7.3-7.6 (3H, m) , 8.10 (IH, d, J=8.2Hz), 8.19 (IH, dd, J=9.2 and 2.3Hz), 9.05 (IH, d, J=2.3Hz) APCI-MASS : m/z = 515 (M+H + ) Preparation 253 1- [6- [4- [4- (8-Methoxyoctyloxy)phenyl]piperazin-l- yl]nicotinoyl]benzotriazole 3-oxide IR (KBr) : 2929, 2854, 1766, 1602, 1510, 1419, 1234 cm "1 NMR (CDCI3, δ) : 1.3-1.9 (12H, m) , 3.2-3.3 (4H, m) , 3.33 (3H, s), 3.36 (2H, t, J=6.4Hz), 3.92 (2H, t, J=6.5Hz), 4.0-4.2 (4H, m) , 6.75 (IH, ,d, J=9.1Hz), 6.87 (2H, d, J=8.9Hz), 7.0-7.2 (2H, m) , 7.4-7.6 (3H, ) , 8.09 (IH, d, J=8.1Hz), 8.20 (IH, dd, J=9.1 and 2.3Hz), 9.05 (IH, d, J=2.3Hz) APCI-MASS : m/z = 559 (M+H + ) Preparation 2:4 1- [4- [5- [4- (4-n-Propyloxyphenyl)phenyl] -1,3,4- thiadiazol-2-yl]benzoyl]benzotriazole 3-oxide IR (KBr) : 1774, 1600, 1234, 985 cm "1 NMR (CDC1 3 , δ) : 1.07 (3H, t, J=7.3Hz), 1.85 (2H, tq, J=6.5 and 7.3Hz), 3.99 (2H, t, J=6.5Hz), 7.01 (2H, d, J=8.7Hz), 7.4-7.7 (5H, m) , 7.72 (2H, d, J=8.7Hz), 8.1-8.2 (2H, m) , 8.28 (2H, d, J=8.6Hz), 8.44 (2H, d, J=8.6Hz) APCI-MASS : m/z = 534 (M+H) ÷ The following compounds (Preparations 255 to 256) were obtained according to a similar manner to that of Preparation 32- Preparation 255 6-Heptylnaphthalene-2-carboxylic acid NMR (CDCI3, δ) : 0.88 (3H, t, J=6.6Hz), 1.15-1.53 (8H, m) , 1.58-1.88 (2H, m) , 2.80 (2H, t, J=7.6Hz), 7.42 (IH, dd, J=1.7 and 8.4Hz), 7.67 (IH, s), 7.84 (IH, d, J=8.6Hz), 7.90 (IH, d, J=8.4Hz), 8.09 (IH, dd, J=1.7 and 8.6Hz), 8.68 (IH, s) APCI-MASS : m/z = 271 (M + +l) , 285 (methyl ester + -l) Preparation 256 3- (E) - [4- [4- (7-Fluoroheptyloxy)phenyl]phenyl]acrylic acid IR (KBr) : 3037.3, 2935.1, 2861.8, 1679.7, 1633.4, 1600.6 cm "1 NMR (DMSO-dg, δ) : 1.30-1.85 (10H, m) , 4.01 (2H, t, J=6.4Hz), 4.44 (2H, dt, J=47.6 and 6.1Hz), 6.54 (IH, d, J=15.9Hz), 7.02 (2H, d, J=8.7Hz), 7.53-7.80 (7H, m) Preparation 257 To a solution of 4-methylpentanol (3.0 ml) in pyridine (20 ml) were added in turn with p-toluenesulfonyl chloride (4.6 g) and 4-N,N-dimethylaminopyridine (1.5 g) at ambient temperature. After stirring at ambient temperature, the reaction mixture was taken up into a mixture of ethyl acetate (100 ml) and water (100 ml) . The separated organic layer was washed in turn with hydrochloric acid(IN), water, aσueous sodium hydrogencarbonate, and brine, and dried over magnesium sulfate. Evaporation gave l-p-Toluenesulfonyloxy-4- methylpentane (5.30 g) . NMR (CDC1 3 , δ) : 0.83 (6H, d, J=6.6Hz), 1.48 (IH, sept, J=6.6Hz), 1.50-1.70 (2H, m) , 2.45 (3H, s), 4.00 (2H, t, J=6.6Hz), 7.34 (2H, d, J=8.1Hz), 7.79 (2H, d, J=8.1Hz) APCI-MASS : m/z = 257 (M + +l) Preparation 258 To a solution of 4-bromo-4'-n-butyloxybiphenyl (3.05 g) in tetrahydrofuran (60 ml) was added 1.55M n-butyllithium in n-hexane (7.74 ml) at -60°C over a period of 10 minutes. The solution was stirred at -30°C for 1.5 hours and cooled to -60°C. To the solution was added triisopropylborate (3.46 ml) over a period of 5 minutes, and the mixture was stirred for 1.5 hours without cooling. To the solution was added IN hydrochloric acid (20 ml) and the solution was stirred for 30 minutes and extracted with ethyl acetate. The organic layer was separated and washed with water, brine and dried over magnesium sulfate. The solvents were removed under reduced pressure and the residue was triturated with n-hexane. The solid was collected by filtration and dried under reduced pressure to give 4- (4-n-Butyloxyphenyl)phenylboronic acid (2.31 g) . IR (KBr) : 3398, 2956, 2919, 2871, 1604, 1531, 1392, 1257 cm "1 NMR (DMSO-dg, δ) : 0.94 (3H, t, J=7.3Hz), 1.4-1.8 (4H, m) , 4.01 (2H, t, J=6.3i. ), 7.01 (2H, d, J=8.7Hz), 7.58 (2H, d, J=7.9Hz) , 7.62 (2H, d, J=8.7Hz), 7.84 (2H, d, J=7.9Hz), 8.03 (2H, s) The following compounds (Preparations 259 to 260) were obtained according to a similar manner to that of Preparation 258. Preparation 259 4- [4- (6-Methoxyhexyloxy)phenyl]phenylboronic acid IR (KBr) : 3448, 3392, 2937, 2861, 1606, 1529, 1346, 1288 cm "1 NMR (DMSO-dg, δ) : 1.3-1.8 (8H, m) , 3.21 (3H, s) , 3.31 (2H, t, J=6.3Hz), 3.99 (2H, t, J=6.4Hz), 7.00 (2H, d, J=8.7Hz), 7.5-7.7 (4H, m) , 7.84 (2H, d, J=8.1Hz), 8.03 (2H, s) APCI-MASS : m/z = 329 (M+H + ) Preparation 260 4- [4- (5-Methoxypentyloxy)phenyl]phenylboronic acid IR (KBr) : 3473, 3369, 3330, 2935, 2863, 1604, 1531, 1338, 1251 cm "1 NMR (DMSO-d 6 , δ) : 1.4-1.8 (6H, ) , 3.22 (3H, s) , 3.3- 3.4 (2H, m) , 3.99 (2H, ,t, J=6.4Hz), 7.00 (2H, d, J=8.7Hz), 7.58 (2H, d, ' J=8.0Hz), 7.61 (2H, d, J=8.7Hz), 7.84 (2H, d, J=8.0Hz), 8.04 (2H, s) APCI-MASS : m/z = 315 (M+H + ) Preparation 262 To a suspension of 4-Methoxycarbonylphenyl boronic acid (648 mg) and 4-iodo-l-heptylpyrazole (876 mg) and Pd(PPh 3 ) 4 (173 mg) in 1, 2-dimethoxyethane (10 ml) was added 2M Na 2 C0 3 aq. (3.6 ml) . The reaction mixture was stirred at 80°C for 2 hours under N2 atmosphere, and poured into ice-water and extracted with ethyl acetate. The organic layer was washed with brine, and dried over MgSO^ . The solvent was removed under pressure. The residue was subjected to column- chromatography on silica gel 60 (Merk) and eluted with n-hexane/ethyl acetate (80:20) . The fractions containing the object compound were combined and evaporated under reduced pressure to give l-heptyl-4- (4-methoxycarbonylphenyl)pyrazole (0.20 g) . IR (KBr pelet) : 2952, 2920, 2848, 1712, 1610, 1288, 1114, 769 cm "1 NMR (DMSO-dg, δ) : 0.85 (3H, t, J=6.7Hz), 1.1-1.4 (8H, m) , 1.7-1.9 (2H, m) , 3.85 (3H, s), 4.11 (2H, t, J=7.0Hz), 7.72 (2H, d, J=8.5Hz), 7.93 (2H, d, J=8.5Hz), 7.99 (IH, s) , 8.34 (IH, s) APCI-MASS : m/z = 301 (M+H + ) The following compounds (Preparations 262 to 268) were obtained according to a similar manner to that of Preparation ______ Preparation 62 Ethyl 4- [4- (4-n-butyloxyphenyl)phenyl]benzoate IR (KBr) : 2958, 2935, 2871, 1714, 1602, 1396, 1280, 1108 cm "1 NMR (CDC1 3 , δ) : 0.99 (3H, t, J=7.3Hz), 1.4-2.0 (7H, m) , 4.02 (2H, t, J=6.4Hz), 4.40 (2H, q, J=7.1Hz), 6.98 (2H, d, J=6.8Hz), 7.56 (2H, d, J=6.8Hz), 7.66 (4H, s), 7.68 (2H, d, J=8.4Hz), 8.12 (2H, d, J=8.4Hz) APCI-MASS : m/z = 375 (M+H) + Preparation 263 Methyl 6- (4-heptyloxyphenyl)nicotinate IR (KBr) : 2954, 2859, 1724, 1597, 1288, 1251, 1116, 783 cm "1 NMR (CDC1 3 , δ) : 0.90 (3H, t, J=6.6Hz), 1.2-1.5 (8H, m) , 1.7-1.9 (2H, m) , 3. : (3H, s), 4.03 (2H, t, J=6.5Hz), 7.00 (2H, d, J=8.8Hz), 7.75 (IH, d, J=8.4Hz), 8.02 (IH, d, J=8.8Hz), 8.30 (IH, dd, J=8.4 and 2.2Hz), 9.23 (IH, d, J=2.2Hz) APCI-MASS : m/z = 328 (M+H + ) Preparation 264 Methyl 6- [4- (4-n-butyloxyphenyl)phenyl]nicotinate IR (KBr) : 2956, 2933, 2871, 1724, 1598, 1282, 1118 cm "1 NMR (CDC1 3 , δ) : 1.00 (3H, t, J=7.3Hz), 1.4-1.9 (4H, m) , 3.98 (3H, s), 4.02 (2H, t, J=6.4Hz), 7.00 (2H, d, J=8.8Hz), 7.59 (2H, d, J=8.8Hz), 7.70 (2H, d, J=8.5Hz), 7.86 (IH, d, J=8.8Hz), 8.13 (2H, d, J=8.5Hz), 8.37 (IH, dd, J=8.δ and 1.6Hz), 9.30 (IH, d, J=1.6Hz) APCI-MASS : m/z = 362 (M+H + ) Preparation 265 Methyl 5- [4- (4-n-butyloxyphenyl)phenyl] furan 2- carboxylate IR (KBr) : 2958, 2933, 2873, 1716, 1483, 1303, 1139 cm "1 NMR (CDC1 3 , δ) : 0.99 (3H, t, J=7.3Hz), 1.5-1.9 (4H, m) , 3.93 (3H, s) , 4.01 (2H, t, J=6.4Hz), 6.75 (IH, d, J=3.6Hz), 6.98 (2H, d, J=8.7Hz), 7.26 (IH, d, J=3.6Hz), 7.56 (2H, d, J=8.4Hz), 7.61 (2H, d, J=8.7Hz), 7.83 (2H, d, J=8.4Hz) APCI-MASS : m/z = * 351 (M+H) + Preparation 266 Ethyl 4- [4- [4- (6-methoxyhexyloxy)phenyl]phenyl]benzoate IR (KBr) : 2937, 2863, 1712, 1602, 1396, 1278, 1108 cm "1 NMR (CDC1 3 , δ) : 1.4-2.0 (11H, m) , 3.34 (3H, s) , 3.39 (2H, t, J=6.4Hz), 4.01 (2H, t, J=6.4Hz), 4.41 (2H, q, J=7.1Hz), 6.98 (2H, d, J=8.7Hz), 7.56 (2H, d, J=8.7Hz), 7.6-7.8 (6H, m) , 8.12 (2H, d, J=8.4Hz) APCI-MASS : m/z = 433 (M+H + ) Preparation 267 4- [4- [4- (5-Methoxypentyloxy)phenyl]phenyl]benzoic acid IR (KBr) : 2939, 2859, 1679, 1587, 1396, 1321, 1292, 1126 cm "1 NMR (DMSO-dg, δ) : 1.3-1.8 (6H, ) , 3.21 (3H, s) , 3.2- 3.4 (2H, m) , 4.01 (2H, t, J=6.5Hz), 7.04 (2H, d, J=8.6Hz), 7.66 (2H, d, J=8.6Hz), 7.7-7.9 (6H, ) , 8.03 (2H, d, J=8.2Hz) APCI-MASS : m/z = 391 (M+H + ) Preparation 268 Methyl 4- [4- [4- (5-methoxypentyloxy)phenyl]phenyl]phenyl acetate IR (KBr) : 2937, 2863, 1739, 1604, 1492, 1255 cm -1 NMR (CDC1 3 , δ) : 1.5-2.0 (6H, m) , 3.34 (3H, s), 3.42 (2H, t, J=6.3Hz), 3.68 (2H, s), 3.72 (3H, s), 4.02 (2H, t, J=6.4Hz), 6.97 (2H, d, J=8.7Hz), 7.36 (2H, d, J=8.2Hz), 7.5-7.7 (8H, m) APCI-MASS : m/z = 419 (M+H + ) Preparation 269 A solution of 3- [2- (4-Hexylphenylamino) ethyl]-2-oxo- oxazolidine hydrochloride (2.131 g) in 25& hydrobromic acid in acetic acid (13.04 ml) was stirred for 96 hours at ambient temperature. The reaction mixture was pulverized with diisopropyl ether. The precipitate was collected by filtration and added to ethanol (15 ml) . The solution was refluxed for 5 hours and pulverized with diisopropyl ether. The precipitate was collected by filtration to give l-(4-n- Hexylphenyl)piperazine dihydrobromide (2.413 g) . IR (KBr) : 2921.6, 2711.4, 2485.8, 1452.1, 1012.4 cm "1 NMR (DMSO-dg, δ) : 0.85 (3H, t, J=6.6Hz), 1.1-1.4 (6H, m) , 1.4-1.6 (2H, m) , 2.49 (2H, t, J=8.4Hz), 3.1-3.4 (8H, m) , 6.54 (2H, s), 6.90 (2H, d, J=8.7Hz), 7.08 (2H, d, J=8.7Hz), 8.78 (IH, s) APCI-MASS : m/z = 247 (M + +H) The following compounds (Preparations 270 to 274) were obtained according to a similar manner to that of Preparation 269. Preparation 270 4- [4- (4-n-Hexylphenyl)piperazin-l-yl]benzoic acid dihydrobromide IR (KBr) : 2956.3, 1691.3, 1664.3, 1602.6, 1232.3 en "1 NMR (DMSO-dg, δ) : 0.85 (3H, t, J=6.5Hz), 1.2-1.4 (10H, ) , 1.4-1.6 (2H, m) , 2.51 (2H, t, J=7.4Hz), 3.2-3.6 (8H, m) , 7.0-7.2 (6H, m) , 7.81 (2H, d, J=8.8Hz) APCI-MASS : m/z = 367 (M + +H) Preparation 271 1- (4-Cyclohexylphenyl)piperazine dihydrobromide IR (KBr) : 2927.4, 1510.0, 1452.1 cm "1 NMR (DMSO-dg, δ) : 1.1-l.j (6H, m) , 1.6-1.9 (4H, m) , 2.41 (IH, m) , 3.1-3.4 (8H, m) , 6.91 (2H, d, J=8.7Hz), 7.11 (2H, d, J=8.7Hz), 8.78 (IH, s) APCI-MASS : m/z = 245 (M + +H) Pre y ion 7 4- [4- (4-Cyclohexylphenyl)piperazin-l-yl]benzoic acid dihydrobromide IR (KBr) : 1668.1, 1602.6, 1230.4, 1189.9 cm "1 APCI-MASS : m/z = 365 (M + +H) Preparation 273 3-Fluoro-4- [4- (4-hydroxyphenyl)piperazin-l-yl]benzoic acid dihydrobromide IR (KBr) : 1708.6, 1610.3 cm "1 NMR (DMSO-dg, δ) : 3.2-3.6 (8H, m) , 6.81 (2H, d, J=8.6Hz), 7.0-7.4 (3H, m) , 7.4-7.8 (2H, m) APCI-MASS : m/z = 317 (M + +H) Preparation 274 4- [4- (4-Hydroxyphenyl)piperazin-l-yl]benzoic acid dihydrobromide IR (KBr) : 1670.1, 1604.5, 1226.5, 775.2 cm "1 NMR (DMSO-dg, δ) : 3.0-3.2 (4H, m) , 3.3-3.5 (4H, m) , 6.68 (2H, d, J=8.8Hz), 6.85 (2H, d, J=8.8Hz), 7.02 (2H, d, J=8.8Hz), 7.79 (2H, d, J=8.8Hz), 8.86 (IH, s), 12.29 (IH, s) APCI-MASS : m/z = 299 (M+H + ) Preparation 75 A mixture of 4-n-hexyloxyaniline (10 g) , ethyl acrylate (56.1 ml), glacial acetic acid (19.25 ml), and cuprous chloride (1.02 g) was heated under reflux with stirring under nitrogen for 26 hours. A solution of the cold product in ether was shaken with water and then with aqueous ammonia. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and filtrate was evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel and eluted with hexane - ethyl acetate (9:1) . The fractions containing the object compound were combined and evaporated under reduced pressure to give Ethyl 3- [N- (2-ethoxycarbonylethyl) -N- (4- hexyloxyphenyl) amino]propionate (15.756 g) . IR (Neat) : 1733.7, 1513.8, 1241.9, 1182.2 cm "1 NMR (CDC1 3 . δ) : 0.90 (3H, t, J=6.5Hz), 1.2-1.55 (6H, m) , 1.24 (6H, t, J=7.1Hz), 1.65-1.85 (2H, m) , 2.51 (4H, t, J=7.2Hz), 3.53 (4H, t, J=7.2Hz), 3.89 (2H, t, J=6.5Hz), 4.12 (4H, q, J=7.1Hz), 6.72 (2H, d, J=9.3Hz), 6.83 (2H, d, J=9.3Hz) APCI-MASS : m/z = 394 (M + +H) Preparation 276 A suspension of methyl 4-formylbenzoate (4.92 g) , hydroxylamine hydrochloride (5.21 g) and sodium acetate (6.15 g) in ethanol (50 ml) was refluxed for 2 hours. The mixture was poured into water and extracted with ethyl acetate and the separated organic layer was washed with brine and dried over magnesium sulfate. The solvents were removed under reduced pressure to give 4-methoxycarbonyl- benzaldehyde oxime (5.28 g) . IR (KBr) : 3291, 1727, 1438, 1284, 1112 cm "1 NMR (CDC1 3 , δ) : 3.93 (3H, s), 7.65 (2H, d, J=8.3Hz), 8.10 (2H, d, J=8.3Hz), 8.18 (IH, s) , 8.27 (IH, s) APCI-MASS : m/z = 180 The following compound was obtained according to a similar manner to that of Preparation 276. Preparation 7 N-Hydroxy-4-n-hexyloxybenzamidine IR (KBr) : 3446, 3349, 2937, 2865, 1650, 1610, 1519, 1392, 1253 cm "1 NMR (DMSO-dg, δ) : 0.88 (3H, t, J=6.4Hz), 1.2-1.8 (8H, ) , 3.97 (2H, t, J=6.5Hz), 5.70 ,'2H, s) , 6.90 ' - • , d, J=8.4Hr- , j 7.58 (2H, d, 8.4 , 9.43 (IH, APCI-MASS : m/ .: = 237 (M+H) + Preparation 278 To a solution of 4-methoxycarbonylbenzaldehyde oxime (896 mg) in N,N-dimethylformamide (10 ml) was added 4N- hydrochloride acid in 1,4-dioxane (1.38 ml) and oxone R (1.69 g) . The suspension was stirred at ambient temperature for 16 hours and poured into ice-water. The object compound was extracted with ethyl acetate and the organic layer was washed with brine, dried over magnesium sulfate. The solvents were removed under reduced pressure to give 4-Methoxycarbonylbenzaldehyde oxime chloride (1.05 g) . IR (KBr) : 3390, 1710, 1436, 1405, 1284, 1232, 1116, 1016 cm "1 NMR (CDC1 3 , δ) : 3.95 (3H, s) , 8.93 (2H, d, J=8.3Hz), 8.10 (2H, d, J=8.7Hz), 8.39 (IH, s) APCI-MASS : m/z = 176 (M-H + -HC1) Preparation 279 A solution of Ethyl 4-oxo-l-(4-n- hexyloxyphenyl)piperidine-3-carboxylate (1.437 g) in 20o hydrochloric acid (7.2 ml) was refluxed for 2 hours, cooled, basified with 60% aqueous sodium hydroxide, and extracted with ethyl acetate. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and filtrate was evaporated under reduced pressure to give 1- (4-n-Hexyloxyphenyl)-4-piperidone (0.959 g) . IR (Neat) : 2931.3, 1716.3, 1511.9, 1243.9, 825.4 cm "1 NMR (CDC1 3 , δ) : 0.90 (3H, t, J=6.5Hz), 1.2-1.6 (6H, m) , 1.65-1.85 (2H, m) , 2.57 (4H, t, J=6.1Hz), 3.46 (4H, t, J=6.1Hz), 3.92 (2H, t, J=6.5Hz), 6.85 (2H, d, J=9.3Hz), 6.95 (2K, d, J=9.3Hz) APCI-MASS : m/z = 276 (M + +H) Preparation 280 A solution of 4-[4- (7-Bromoheptyloxy)phenyl]bromobenzene (0.25 g) in a solution of tetra n-butylammonium fluoride (tetrahydrofuran solution, IM, 2.9 ml) was heated to 50°C for 2 hours. After cooling to ambient temperature, the solution was taken up into a mixture of ethyl acetate (20 ml) and water (20 ml) . The separated organic layer was washed with water, brine, and dried over magnesium sulfate. Evaporation gave a residue which was chromatographed on silica gel (30 ml) eluting with a mixture of n-hexane and ethyl acetate (100:0-97:3, V/V) . The fractions which contained the objective compound were collected and evaporated a residue which was triturated with n-hexane to give 4- [4- (7- Fluoroheptyloxy)phenyl]bromobenzene (104 mg) . IR (KBr) : 2937.1, 2859.9, 1606.4 cm "1 NMR (CDC1 3 , δ) : 1.20-1.90 (10H, m) , 3.99 (2H, t, J=6.4Hz), 4.45 (2H, dt, J=47.3 and 6.1Hz), 6.95 (2H, d, J=6.7Hz), 7.40 (2H, d, J=6.7Hz), 7.47 (2H, d, J=6.7Hz), 7.52 (2H, d, J=6.7Hz) The following compound was obtained according to a similar manner to that of Preparation 280. reparation 231 4-[4- (6-Fluorohexyloxy)phenyl]bromobenzene NMR (CDC1 3 , δ) : 1.40-1.95 (8H, m) , 4.01 (2H, t, J=6.4Hz), 4.47 (2H, dt, J=47.5 and 6.0Hz), 6.95 (2H, d, J=8.6Hz), 7.35-7.59 (6H, m) Preparation 292 A solution of 4- [4- (8-Bromooctyloxy)phenyl]bromobenzene (3.7 g) in a mixture of sodium methoxide (4.9M in methanol, 17 ml), N,N-dimethylformamide (20 ml) and tetrahydrofuran (8 ml) was heated to 80°C for 3 hours. The reaction mixture was taken up into a mixture of ethyl acetate (200 ml) and water (100 ml) . The separated organic layer was washed in turn with water, brine, dried over magnesium sulfate. Evaporation gave a residue which was subjected to column chromatography (silica gel, 100 ml) eluting with n-hexane to give 4-[4- (8- Methoxyoctyloxy)phenyl]bromobenzene (2.73 g) . IR (KBr) : 2935.1, 2858.0, 1604.5 cm "1 NMR (CDC1 3 , δ) : 1.25-1.70 (10H, m) , 1.70-1.95 (2H, m) , 3.33 (3H, s), 3.37 (2H, t, J=6.5Hz), 3.99 (2K, t, J=6.5Hz), 6.95 (2H, d, J=8.8Hz), 7.35-7.66 (6H, m) APCI-MASS : m/z = 391 (M + ) The following compounds (Preparations 283 to 284) were obtained according to a similar manner to that of Preparation __§__. Preparation 283 4- [4- (6-Methoxyhexyloxy)phenyl]bromobenzene NMR (CDC1 3 , δ) : 1.50-1.70 (6H, m) , 1.70-1.95 (2H, ) , 3.34 (3K, s), 3.40 (2H, t, J=6.2Hz), 3.99 (2H, t, J=6.5Hz), 6.95 (2H, d, J=8.7Hz), 7.30-7.60 (6H, m) APCI-MASS : m/z = 365 (M + +2) Preparation 284 4- [4- (7-Methoxyheptyloxy)phenyl]bromobenzene IR (KBr) : 2935.1, 2854.1, 1604.5 cm "1 NMR (CDC1 3 , δ) : 1.25-1.70 (8H, m) , 1.70.1.95 (2H, m) , 3.33 (3H, s), 3.37 (2H, t, J=6.4Hz), 3.98 (2H, t, J=6.5Hz), 6.95 (2H, d, J=8.8Hz), 7.35-7.56 (6H, m) APCI-MASS : m/z = 379 (M + +2) Preparation 285 N- (4-octylphenyl) -N'-aminourea, Formamidine acetate (12.76 g) and N-carbazoyl-4-octylaniline (6.458 g) in N,N- dimethylformamide (19.4 ml) were stirred at 150°C for 6 hours. The reaction mixture was pulverized with water. The precipitate was collected by filtration and washed with water to give 4- (4-Octylphenyl) -2, 3-dihydro-4H-l, 2, 4-triazol-3-one (4.27 g) . IR (KBr) : 3214.8, 3085.5, 1704.8 cm "1 NMR (CDC1 3 , δ) : 0.88 (3H, t, J=6.7Hz), 1.2-1.5 (10H, m) , 1.5-1.8 (2H, m) , 2.64 (2H, t, J=7.9Hz), 7.29 (2H, d, J=8.5Hz), 7.43 (2H, d, J=8.5Hz), 7.67 (IH, d, J=1.3Hz), 10.31 (IH, s) APCI-MASS : m/z = 274 (M+H + ) The following compound (Preparation 286) was obtained according to a similar manner to that of Preparation 285. Preparation 286 4- [4- (4-tert-Butoxycarbonylpiperazin-l-yl) henyl] -2,3- dihydro-4H-l, 2, 4-triazol-3-one IR (KBr) : 3200, 1699.0, 918.0 cm "1 NMR (CDC1 3 , δ) : 1.49 (9H, s) , 3.17 (4H, t, J=4.9Hz), 3.60 (4H, t, J=4.9Hz), 7.00 (2H, d, J=9.0Hz), 7.40 (2H, d, J=9.0Hz), 7.63 (IH, s), 10.4 (IH, s) APCI-MASS : m/z = 346 (M+H + ) Preparation 287 A mixture of Methyl 6- (1-heptynyl) aphthalene-2- carboxylate (4.51 g) and platinum oxide (0.4 g) in tetrahydrofuran was stirred under 3.5 atm pressure of hydrogen for 5 hours. The catalyst was filtered off and the filtlate was evaporated to give Methyl 6-heptylnaphthalene-2- carboxylate (4.40 g) . NMR (CDC1 3 , δ) : 0.88 (3H, t, J=6.6Hz), 1.16-1.50 (8H, m) , 1.50-1.80 (2H, m) , 2.78 (2H, t, J=7.6Hz), 3.97 (3H, s), 7.39 (IH, dd, J=17 and 8.4Hz), 7.64 (IH, s), 7.79 (IH, d, J=8.6Hz), 7.86 (IH, d, J=8.4Hz), 8.02 (IH, dd, J=1.7 and 8.6Hz), 8.r7 (IH, s) APCI-MASS : m/z = 285 (M + +l) The following compound (Preparation 288) was obtained according to a similar manner to that of Preparation 287. Preparation 288 Methyl 6-hexylnaphthalene-2-carboxylate NMR (CDCI3, δ) : 0.88 (3H, t, J=6.8Hz), 1.17-1.53 (6H, m) , 1.60-1.82 (2H, m) , 2.79 (2H, t, J=7.7Hz), 3.97 (3H, s), 7.39 (IH, dd, J=l.7 and 8.4Hz), 7.64 (IH, s), 7.80 (IH, d, J=8.6Hz), 7.86 (IH, d, J=8.4Hz), 8.03 (IH, dd, J=l.7 and 8.6Hz), 8.57 (IH, s) APCI-MASS : m/z = 271 (M+l) Preparation 289 To a stirred solution of Methyl 6-hydroxynaphthalene-2- carboxylate (3.0 g) in dichloromethane (40 ml) were added in turn diisopropylethylamine (3.9 ml) and triflie anhydride (3.0 ml) at -40°C. After stirring at -40°C for 20 minutes, the mixture was taken up into a mixture of ethyl acetate and cold water. The organic layer was separated, washed with brine, dried over magnesium sulfate, and dried in vacuo. The residue was taken up into piperidine (20 ml) and to the solution were added 1-heptyne (4.0 ml) and tetrakis (triphenylphosphine)palladium(0) (0.5 g) . After heating to 85°C for 1 hour under nitrogen atmosphere, the reaction mixture was evaporated in vacuo. The residue was diluted with ethyl acetate, and the solution was washed in turn with hydrochloric acid and brine, dried over magnesium sulfate and evaporated in vacuo. The residue was chromatographed on silica gel (200 ml) eluting with a mixture of n-hexane and ethyl acetate (9:1, V/V) to give Methyl 6- (l-heptynyl)naphthalene-2-carboxylate (4.01 g) . NMR (CDC1 3 , δ) : 0.94 (3H, t, J=7.1Hz), 1.30-1.70 (6H, m) , 2.46 (2H, t, J=7.0Hz), 3.97 (3K, s) , 7.50 (IH, dd, J=1.7 and 8.6Hz), 7.80 (IH, d, J=8.6Hz), 7.86 (IH, d, J=8.6Hz), 8.04 (IH, dd, J=1.7 and 8.6Hz), 8.55 (IH, s) APCI-MASS : m/z = 281 (M + +l) The following compound was obtained according to a similar manner to that of Preparation 289. Preparation 290 Methyl 6- (1-hexynyl) naphthalene-2-carboxylate NMR (CDC1 3 , δ) : 0.97 (3H, t, J=7.1Hz), 1.40-1.71 (4H, m) , 2.47 (2H, t, J=6.8Hz), 3.98 (3H, s), 7.50 (IH, dd, J=1.5 and 8.5Hz), 7.79 (IH, d, J=8.6Hz), 7.85 (IH, d, J=8.5Hz), 7.92 (IH, s), 8.04 (IH, dd, J=l .7 and 8.6Hz) , 8.55 (IH, s) APCI-MASS : m/z = 267 (M + +l) Preparation 291 To a solution of 4-octylaniline (5 ml) in a mixture of pyridine (12.5 ml) and chloroform (40 ml) was added phenyl chloroformate (2.95 ml) and stirred for 1.5 hours at ambient temperature. The reaction mixture was added to a mixture of water and ethyl acetate. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 4-Octyl-N-phenoxycarbonylaniline (4.51 g) IR (KBr) : 3318.9, 1714.4, 1234.2 cm "1 NMR (CDCI3, δ) : 0.88 (3H, t, J=6.2Hz), 1.2-1.4 (10H, m) , 1.5-1.7 (2H, m) , 2.57 (2H, t, J=7.3Hz), 6.88 (IH, s), 7.1-7.5 (9H, m) The following compounds (Preparations 292 to 299) were obtained according to a similar manner to that of Preparation 291. Preparation 292 4- (4-tert-Butoxycarbonylpiperazin-l-yl) -N- phenoxycarbonylaniline IR (KBr) : 3309.2, 1743.3, 1658.5, 1197.6 cm "1 NMR (CDCI3, δ) : 1.48 (9H, s), 3.08 (4H, t, J=5.3Hz), 3.58 (4H, t, J=5.3Hz), 6.87 (IH, s) , 6.91 (2H, d, J=9Hz), 7.1-7.5 (7H, ) APCI-MASS : m/z = 398 (M+H + ) Preparation 293 1- (4-Cyclohexylbenzoyl) -2- (4-methoxycarbonylbenzoyl) - hydrazine IR (KBr) : 3236, 2925, 2852, 1726, 1679, 1637, 1278, 1110 cm "1 NMR (DMSO-dg, δ) : 1.1-1.5 (5H, m) , 1.6-2.0 (5H, m) , 2.60 (IH, m) , 3.90 (3H, s), 7.37 (2H, d, J=8.0Hz), 7.85 (2H, d, J=8.0Hz), 8.0-8.2 (4H, m) , 10.48 (IH, s), 10.68 (IH, s) APCI-MASS : m/z = 381 (M+H) τ Preparation 294 1- [4- (Piperidin-l-yl)benzoyl] -2- (4- methoxycarbonylbenzoyl]hydrazine IR (KBr) : 3500, 3286, 2941, 2854, 1712, 1689, 1650, 1606, 1286, 1242 cm "1 NMR (DMSO-dg, δ) : 1.59 (6H, s), 3.33 (4H, s), 3.90 (3H, s), 6.97 (2H, d, J=8.8Hz), 7.79 (2H, d, J=8.8Hz), 8.02 (2H, d, J=8.4Hz), 8.09 (2H, d, J=8.4Hz), 10.23 (IH, s), 10.57 (IH, s) APCI-MASS : m/z = 382 (M+H) + Preparation 295 1- [4- (4-n-Propyloxyphenyl)benzoyl] -2- (4- methoxycarbonylbenzoyl]hydrazine IR (KBr) : 3230, 1724, 1679, 1654, 1280, 1108 cm "1 NMR (DMSO-dg, δ) : 1.00 3H, d, J=7.5Hz), 1.76 (2H, tq, J=6.5 and 7.5Hz), 3.91 (3H, s) , 7.05 (2H, d, J=8.7Hz), 7.71 (2H, d, J=8.7Hz), 7.79 (2H, d, J=8.5Hz), 8.00 (2H, d, J=8.5Hz), 8.05 (2H, d, J=8.6Hz), 8.11 (2H, d, J=8.6Hz), 10.60 (IH, s), 10.72 (IH, s) APCI-MASS : m/z = 433 (M+H) + Preparation 296 1- (4-Methoxycarbonylbenzoyl) -2-decanoylhydrazine IR (KBr) : 3220, 2919, 2850, 1^24, 1643, 1600, 1567, 1479, 1284 cm -1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.8Hz), 1.2-1.7 (14H, m) , 2.18 (2H, t, J=7.4Hz), 3.89 (3H, s), 7.97 (2H, d, J=8.5Hz), 8.06 (2H, d, J=8.5Hz), 9.15 (IK, s), 10.49 (IH, s) APCI-MASS : m/z = 349 (M+H + ) Preparation 297 1- (4-Methoxycarbonylbenzoyl) -2- (trans-4-n- pentylcyclohexylcarbonyl) hydrazine IR (KBr) : 3201, 2923, 2852, 1727, 1600, 1567, 1479, 1282 cm "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.9Hz), 0.9-1.0 (2H, m) , 1.1-1.5 (11H, m) , 1.7-1.9 (4H, m) , 2.20 (IH, m) , 3.88 (3H, s), 7.97 (2H, d, J=8.6Hz), 8.06 (2H, d, J=8.6Hz), 9.85 (IH, s), 10.46 (IH, s) APCI-MASS : m/z = 375 (M+H + ) Preparation 298 I- [4- (8-Methoxyoctyloxy)benzoyl] -2- (4- methoxycarbonylbenzoyl) hydrazine IR (KBr) : 3213, 2935, 2856, 1718, 1600, 1567, 1465, 1282 cm "1 NMR (DMSO-dg, δ) : 1.2-1.8 (12H, m) , 3.21 (3H, s) , 3.29 (2H, t, J=6.4Hz), 3.90 (3H, s), 4.04 (2H, t, J=6.5Hz), 7.04 (2H, d, J=8.8Hz), 7.90 (2H, d, J=8.8Hz), 8.04 (2H, d, J=8.7Hz) 3.10 (2H, d, J=8.7Hz), 10.41 (IH, s), 10.64 :, s) APCI-MASS : m/z = 457 (M+H + ) Preparation 299 1- (4-Octyloxybenzoyl) -2- (4-methoxycarbonylbenzoyl) - hydrazine IR (KBr) : 3224, 2923, 2854, 1724, 1681, 1643, 1502, 1434, 1282, 1253, 1106 cm -1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.8Hz), 1.2-1.5 (10H, m) , 1.6-1.8 (2H, m) , 3.89 (3H, s), 4.04 (2H, t, J=6.3Hz), 7.04 (2H, d, J=8.7Hz), 7.90 (2H, d, J=8.7Hz), 8.03 (2H, d, J=8.6Hz), 8.10 (2H, d, J=8.6Hz), 10.42 (IH, s), 10.64 (IH, s) APCI-MASS : m/z = 427 (M+H + ) Preparation 300 A solution of Methyl 4-n-hexyloxybenzoate (2.00 g) and hydrazine hydrate (4.24 g) in ethanol (10 ml) was refluxed for 6 hours. After cooling, the reaction mixture was poured into water. The precipitate was collected by filtration, washed with water and dried over P2O5 under reduced pressure to give N- (4-n-hexyloxybenzoyl) hydrazine (1.96 g) . IR (KBr) : 3311, 2954, 2869, 1623, 1253 cm "1 NMR (DMSO-dg, δ) : 0.87 (3H, t, J=6.8Hz), 1.2-1.5 (6H, m) , 1.6-1.8 (2H, m) , 4.00 (2H, t, J=6.5Hz), 4.40 (2H, s), 6.95 (2H, d, J=8.6Hz), 7.77 (2H, d, J=8.6Hz), 9.59 (IH, s) APCI-MASS : m/z = 237 (M+H) + The following compounds (Preparations 301 to 308) were obtained according to a similar manner to that of Preparation 300. Preparation 301 N- (4-Octylphenyl) -N'-aminourea IR (KBr) : 3309.2, 1683.6, 1554.3 cm "1 NMR (DMSO-dg, δ) : 0.85 (3H, t, J=6.7Hz), 1.1-1.4 (10H, m) , 1.4-1.6 (2H, m) , 2.48 (2H, t, J=8.9Hz), 4.32 (2H, s), 7.03 (2H, d, J=8.4Hz), 7.32 (IH, s) , 7.38 (2H, d, J=8.4Hz), 8.50 (IH, s) Preparation 302 N- [4- (4-tert-Butoxycarbonylpiperazin-l-yl) phenyl] -N'- aminourea IR (KBr) : 3237.9, 1695.1, 1670.1, 1540.8, 1230.4 cm "1 NMR (DMSO-dg, δ) : 1.42 (9H, s), 2.97 (4H, t, J=4.9Hz), 3.44 (4H, t, J=4.9Hz), 4.30 (2H, s), 6.85 (2H, d, J=9.0Hz), 7.26 (IK, s), 7.36 (2K, d, J=9.0Hz), 8.41 (IK, si Preparation 303 4-Cyclohexylbenzoylhydrazine IR (KBr) : 3318, 2925, 2852, 1625, 1606, 1527, 1326 cm "1 NMR (DMSO-dg, δ) : 1.1-1.5 (5H, m) , i .6-2.0 (5H, m) , 2.4-2.6 (IH, m) , 4.44 (2H, s), 7.27 (2H, d, J=8.2Hz), 7.73 (2H, d, J=8.2Hz), 9.66 (IH, s) APCI-MASS : m/z = 219 (M+H) + Preparation 304 4- (Piperidin-l-yl)benzoylhydrazine IR (KBr) : 3263, 2852, 1612, 1504, 1245, 1124 cm "1 NMR (DMSO-dg, δ) : 1.57 (6H, s), 3.25 (4H, s), 4.35 (2H, s), 6.90 (2H, d, J=9.0Hz), 7.68 (2H, d, J=9.0Hz), 9.44 (IH, s) APCI-MASS : m/z = 220 (M+H) + Preparation 3Q5 4- (4-n-Propyloxyphenyl)benzoylhydrazine IR (KBr) : Ξ_50, 3276, 1610, 1494, 1288, 978 cm "1 NMR (DMSO-d 3 , δ) : 0.99 (3H, t, J=7.5Hz), 1.75 (2H, tq, J=6.5 and 7.5Hz), 3.98 (2H, t, J=6.5Hz), 4.50 (2H, s), 7.03 (2H, d, J=8.8Hz), 7.65 (2H, d, J=8.8Hz), 7.69 (2H, d, J=8.4Hz), 7.88 (2H, d, J=8.4Hz), 9.79 (IH, s) APCI-MASS : m/z = 271 (M+H + ) Preparation 306 4-Methoxycarbonylbenzoylhydrazine IR (KBr) : 3322, 3250, 3016, 1727, 1658, 1621, 1565, 1432, 1280, 1110 cm "1 NMR (DMSO-dg, δ) : 3.87 (3H, s), 4.58 (2H, s) , 7.93 (2H, dd, J=8.6 and 3.1Hz), 7.02 (2H, dd, J=8.6 and 3.1Hz), 9.97 (IH, s) APCI-MASS : m/z = 195 (M+H^) Preparation 307 Trans-4-n-pentylcyclohexyicarbonylhydrazine IR (KBr) : 3303, 3199, 2954, 2925, 2850, 1639, 1619, 1533, 1457 cm "1 ΝMR (DMSO-dg, δ) : 0.8-1.0 (6H, m) , 1.1-1.5 (10H, m) , 1.6-2.2 (5H, m) , 4.10 (2H, s), 8.85 (IH, s) APCI-MASS : m/z = 213 (M+H + ) Preparation 308 4- (8-Methoxyoctyloxy)benzoylhydrazine IR (KBr) : 3309, 2937, 2852, 1606, 1494, 1253 cm "1 ΝMR (DMSO-dg, δ) : 1.2-1.8 (12H, m) , 3.20 (3H, s), 3.25 (2H, t, J=6.5Hz), 3.99 (2H, t, J=6.5Hz), 4.39 (2H, s), 6.95 (2H, d, J=8.8Hz), 7.77 (2H, d, J=8.8Hz), 9.58 (IH, s) APCI-MASS : m/z = 295 (M+H) + Preparation 309 To a stirred solution of 4-bromo- '-n-heptylbiphenyl (2.71 g) in tetrahydrofuran (100 ml) was added dropwise a solution of n-butyllithium in a mixture of diethyl ether and n-hexane (1.6M, 5.1 ml) at -78°C. After stirring at -78°C for 30 minutes, the resultant mixture was added to a solution of diethyl oxalate (3.4 ml) in tetrahydrofuran (50 ml) at -78°C. The resultant mixture was allowed to warm to 0°C for about 1 hour, and to the mixture was added acetic acid (0.5 ml) . Evaporation gave a residue which was taken up into a mixture of water and ethyl acetate. The organic layer was separated, washed with brine, dried over magnesium sulfate. Evaporation gave a residue which was chromatographed on silica gel (200 ml) eluting with a mixture of n-hexane and ethyl acetate (10:0-95:5, V/V) to give l-Ethyl-2- (4-n heptylphenyl) ethanedione (2.23 g) . NMF (CDC1 3 , δ) : 0.88 (3H, t, J=6.6Hz), 1.10-1.50 (8H, m) , 1.44 (3H, t, J=7.1Hz), 1.50-1.80 (2H, m) , 2.66 (2H, t, J=7.7Hz), 4.47 (2H, q, J=7.1Hz), 7.20-7.40 (2H, m) , 7.50-7.64 (2H, ) , 7.64-7.85 (2H, m) , 8.00-8.20 (2H, m) APCI-MASS : m/z = 353 (M + +l) Preparation 310 To a suspension of sodium hydride ( 60% in oil, 0.37 g) in tetrahydrofuran (40 ml) was added by portions 4-acetyl-4'- n-heptylbiphenyl (2.50 g) at ambient temperature. After stirring at ambient temperature for 1 hour, to the solution was added triethyl phosphonoacetate (1.9 ml) and the mixture was heated to reflux for 5 hours. After cooling to ambient temperature, to the mixture was added acetic acid (0.53 ml) and evaporated. The residue was taken up into a mixture of water and ethyl acetate. The separated organic layer was washed with brine, dried over magnesium sulfate and evaporated. The residue was chromatographed on silica gel (200 ml) eluting with mixture of n-hexane and diisopropyl ether (99:1-20:1, V/V) to give Ethyl (E)-3-[4-(4- heptylphenyl)phenyl] -2-butenoate (2.19 g) . NMR (CDC1 3 , δ) : 0.88 (3K, t, J=6.6Hz), 1.13-1.48 (8H, ) , 1.48-1.78 (2H, m) , 2.61 (3H, s) , 2.65 (2H, t, J=7.4Hz), 4.22 (2K, q, J=7.1Hz), 6.20 (IH, t, J=2.7Hz), 7.23-7.28 (2H, m) , 7.50-7.63 (6H, m) APCI-MASS : m/z = 365 (M + +l) Preparation 311 To a solution of 4-bromo-4 '-n-heptylbiphenyl (5.1 g) in tetrahydrofuran (60 ml) was added a solution of n- butyllithium in a mixture of n-hexane and diethyl ether (1.6M, 9.7 ml) at -60°C. After stirring at -60°C for 30 minutes, to the mixture was added N,N-dimethylacetamide (4.3 ml) and the reaction mixture was allowed to warm to 0°C. The reaction mixture was taken up into a mixture of cold water and ethyl acetate, and the pH was adjusted to around 1 with IN hydrochloric acid. The organic layer was separated, washed with brine, dried over magnesium sulfate and evaporated. The residue was chromatographed on silica gel (150 ml) eluting with a mixture of n-hexane and ethyl acetate (20:1, V/V) to give 4-Acetyl-4 '-n-heptylbiphenyl (1.60 g) . NMR (CDC1 3 , δ) : 0.89 (3H, t, J=6.6Hz), 1.05-1.48 (8H, m) , 1.48-1.75 (2H, m) , 2.65 (2H, t, J=7.6Hz), 2.63 (3H, s), 7.20-7.31 (2H, m) , 7.52-7.58 (2H, m) , 7.65-7.70 (2H, m) , 7.97-8.05 (2H, m) APCI-MASS : m/z = 295 (M+l) Preparation 312 To a solution of Methyl 4- [4- (8-hydroxyoctyloxy)phenyl] - benzoate (500 mg) and dihydropyrane (141 mg) in dichloromethane (15 ml) was added p-toluenesulfonic acid (5 ml) . The mixture was stirred at ambient temperature for 10 minutes and diluted with dichloromethane and washed with water and brine. The separated organic layer was dried over magnesium sulfate and evaporated under reduced pressure to give Methyl 4- [4- (8-tetrahydropyran-2-yl-oxyoctyloxy)phenyl] - benzoate (616 mg) . IR (KBr) : 2935, 2856, 1722, 1602, 1438, 1290, 1199 cm "1 NMR (CDC1 3 , δ) : 1.3-2.0 (18H, m) , 3.3-3.9 (4H, m) , 3.93 (3H, s), 4.00 (2H, t, J=6.5Hz), 4.5-4.6 (IH, m) , 6.98 (2H, d, J=8.7Hz), 7.56 (2H, d, J=8.7Hz), 7 . 62 ( 2H, d, J=8 . 3Hz ) , 8 . 07 ( 2H, d, J=8 . 3Hz ) Preparation 313 To a solution of titanium(IV) chloride (11.6 g) in dichloromethane (100 ml) was added 4-n-Pentyloxyacetophenone (10.3 g) and Methyl 4-formylbenzoate (8.21 g) in dichloromethane (50 ml) dropwise at 0°C. To the mixture was added triethylamine (11.15 ml) in dichloromethane (30 ml) . The mixture was stirrer t 0 C C for 30 minutes and diluted with n-hexane. The or .ic layer was washed with water (four times), brine and drie over magnesium sulfate. The solvents were removed under reduced pressure and the residue was triturated with iso-propyl ether. The solid was collected by filtration and dried to give 1- (4-Methoxycarbonylphenyl) -3- (4-n-pentyloxyphenyl) -l-propen-3-one (4.02 g) . IR (KBr) : 2950, 2910, 2863, 1718, 1654, 1606, 1274, 1176 cm "1 NMR (CDC1 3 , δ) : 0.94 (3H, t, J=6.9Hz), 1.3-1.6 (4H, m) , 1.8-2.0 (2H, m) , 3.93 (3H, s) , 4.04 (2H, t, J=6.5Hz), 6.97 (2H, d, J=8.8Hz), 7.60 (IH, d, J=15.7Hz), 7.68 (2H, d, J=8.4Hz), 7.80 (IH, d, J=15.7Hz), 8.0-8.2 (4H, m) APCI-MASS : m/z = 353 (M+H ÷ ) Preparation 314 To a solution of titanium(IV) chloride (13.88 g) in dichloromethane (100 ml) was added Ethyl 4-acetylbenzoate (11.53 g) and 4-n-pentyloxybenzaldehyde (12.69 g) in dichloromethane (50 ml) is added c -opwise at 0°C. To the mixture was added triethylamine (12.44 ml) in dichloromethane (30 ml) . The mixture was stirred at 0°C for 30 minutes and diluted with ethyl acetate. The organic layer was washed with water (four times) and brine and dried over magnesium sulfate. The solvents were removed under reduced pressure and the residue was triturated with n-hexane. The solid was collected by filtration and dried to give l-(4-n- Pentyloxyphenyl) -3- (4-ethoxycarbonylphenyl) -l-propen-3-one (13.45 g) . IR (KBr) : 2956, 2929, 2861, 1718, 1656, 1594, 1510, 1272 cm "1 NMR (CDC1 3 , δ) : 0.94 (3K, t, J=7.1Hz), 1.3-1.9 (9H, m) , 4.01 (2H, t, J=6.5Hz), 4.42 (2H, q, J=7.1Hz), 6.93 (IH, d, J=8.7Hz), 7.37 (IH, d, J=15.6Hz), 7.60 (2H, d, J=8.7Hz), 7.81 (IH, d, J=15.6Hz), 8.03 (2H, d, J=8.5Hz), 8.16 (2H, d, J=8.5Hz) APCI-MASS : m/z = 367 (M+H + ) The following compound was obtained according to a similar manner to that of Preparation 314. Preparation 315 Ethyl 4-oxo-l- (4-n-hexyloxyphenyl)piperidine-3- carboxylate IR (Neat) : 1664.3, 1511.9, 1243.9, 1216.9 cm "1 NMR (CDC1 3 , δ) : 0.90 (3H, t, J=6.5Hz), 1.2-1.5 (6K, ) , 1.32 (3H, t, J=7.1Hz), 1.65-1.85 (2H, m) , 2.51 (2H, t, J=5.8Hz), 3.31 (2H, t, J=5.8Hz), 3.76 (2H, s), 3.91 (2H, t, J=6.5Hz), 4.26 (2H, q, J=7.1Hz), 6.84 (2H, d, J=9.2Hz), 6.94 (2H, d, J=9.2Hz), 12.06 (IH, s) APCI-MASS : m/z = 348 (M + +H) Preparation 316 To a solution of 4-n-Hexyloxybenzoylhydrazine (1.96 g) and pyridine (0.74 ml) in tetrahydrofuran (20 ml) was added a solution of terephthalic acid monomethyl ester chloride (1.56 g) in tetrahydrofuran (15 ml) dropwise at 0°C. The reaction mixture was stirred at room temperature for 2 hours, and poured into water. The precipitate was collected by filtration and washed with acetonitrile. The residue was dried under reduced pressure to giv- 1- (4-n-Hexyloxybenzoyl) - 2- (4-methoxycarbonylbenzoyl)hydrazir.e (2.99 g) . IR (KBr) : 3230, 3023, 2954, 2858, 1724, 1681, 1643, 1280, 1251, 1105 cm "1 NMR (DMSO-dg, δ) : 0.88 (3H, t, J=6.6Hz), 1.2-1.5 (6H, m) , 1.6-1.8 (2H, m) , 3.90 (3H, s), 4.04 (2H, t, J=6.4Hz), 7.04 (2H, d, J=8.7Hz), 7.90 (2K, d, J=8.7Hz), 8.03 (2H, d, J=8.4Hz), 8.10 (2H, d, J=8.4Hz), 10.42 (IH, s) , 10.65 (IH, s) APCI-MASS : m/z = 399 (M+H) " " Preparation 317 A mixture of 1- (4-n-Hexyloxyphenyl) -4-piperidone (0.823 g) , 1- (4-Ethoxycarbonylphenyl)piperazine (0.7 g) , and titanium(IV) isopropoxide (1.11 ml) was stirred at room temperature. After 1 hour, the IR spectrum of the mixture showed no ketone band, and the viscous solution was diluted with absolute ethanol (3 ml). Sodium cyanoborohydride (0.121 g) was added, and the solution was stirred for 3 hours. Water (3 ml) was added with stirring, and the resulting in organic precipitate was filtered and washed with ethanol. The filtrate was extracted with ethyl acetate. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and filtrate was evaporated under reduced pressure to give Ethyl 4- [4- [1- (4-n- hexyloxypheny1)piperidin-4-yl]piperazin-l-yl]benzoate (331 mg) . IR (KBr) : 1708.6, 1606.4, 1511.9, 1284.4, 1236.1 cm "1 NMR (CDC1 3 , δ) : 0.90 (3H, t, J=6.5Hz), 1.2-1.55 (6H, m) , 1.37 (3H, t, J=7.1Hz), 1.6-1.85 (4H, m) , 1.95 (2H, d, J=12Hz), 2.41 (IH, m) , 2.62 (2H, d, J=llHz), 2.75 (4H, t, J=5.0Hz), 3.35 (4H, t, J=5.0Hz), 3.58 (2H, d, J=llHz), 3.90 (2H, t, J=6.5Hz), 4.32 (2H, q, J=7.1Hz), 6.7-7.0 (6H, m) , 7.92 (2H, d, J=9.0Hz) APCI-MASS : m/z = 494 (M + +H) The following compound was obtained according to a similar manner to that of Preparation 317. Preparation 318 l-tert-Butoxycarbonyl-4- (4-phenylcyclohexyl)piperazine IR (KBr) : 1697.1, 1245.8, 1170.6, 1124.3, 700 cm "1 NMR (CDC1 3 , δ) : 1.2-1.65 (17H, m) , 1.9-2.1 (4H, m) , 2.3-2.6 (2H, m) , 2.55 (4H, t, J=5.0Hz), 3.44 (4H, t, J=5.0Hz), 7.1-7.4 (5H, m) APCI-MASS : m/z = 345 (M + +H) Preparation 319 To a suspension of 1- (N,N-dimethylamino) -2- (4- ethoxycarbonylbenzoyl) ethylene (0.742 g) and 4-n- hexyloxybenzamidine hydrochloride (0.847 g) in methanol (10 ml) was added 28° sodium methoxide in methanol (0.64 ml) . The suspension was refluxed for 6 hours, and partitioned with ethyl acetate and water. The organic layer was washed with water and brine, dried over magnesium sulfate and evaporated under reduced pressure. The residue was triturated with acetonitrile, collected by filtration and dried under reduced pressure to give Methyl 4- [2- (4-n-hexyloxyphenyl)pyrimidin-6- yl]benzoate (0.61 g) . IR (KBr) : 2931, 2861, 1722, 1606, 1558, 1251 cm "1 NMR (CDC1 3 , δ) : 0.95 (3H, t, J=6.7Hz), 1.2-1.6 (6H, m) , 1.8-2.0 (2H, m) , 3.97 (3H, s), 4.05 (2H, t, J=6.5Hz), 7.02 (2H, d, J=8.8Hz), 7.56 (IH, d, J=5.2Hz), 8.18 (2H, d, J=8.6Hz), 8.28 (2H, d, J=8.6Hz), 8.52 (2H, d, J=8.8Hz), 8.83 (IH, d, J=5.2Hz) APCI-MASS : m/z = 391 (M+H + ) Preparation 32Q A solution of 1- (4-Methoxycarbonylphenyl) -3- (4-n- pentyloxyphenyl) -l-propen-3-one (4.0 g) and hydroxyamine hydrochloride (3.93 g) in ethanol (40 ml) was refluxed for 4 hours. The mixture was diluted with ethyl acetate, and the organic layer was washed with water (x 2) , brine and dried over magnesium sulfate. The solvents were removed under reduced pressure to give crude oxime. To a solution of crude oxime in 1, 2-dichloroethane (20 ml) was added activated- manganese (IV) oxide (10.0 g) . The reaction mixture was refluxed for 2 hours and filtered. The residue was washed with dichloromethane. The solvents were removed under reduced pressure and the residue was triturated with acetonitrile. The solid was collected by filtration and dried to give Methyl 4- [3- (4-n-pentyloxyphenyl) isoxazol-5- yl]benzoate (0.98 g) . IR (KBr) : 2940, 2871, 1720, 1612, 1278, 1249, 1178, 1108 cm "1 NMR (DMSO-dg, δ) : 0.94 (3H, t, J=7.2Hz), 1.2-1.6 (4H, m) , 1.7-1.9 (2H, m) , 3.95 (3H, s) , 4.01 (2H, t, J=6.5Hz), 6.87 (IH, s) , 6.98 (2H, d, J=8.9Hz), 7.79 (2H, d, J=8.9Hz), 7.89 (2H, d, J=8.6Hz), 8.15 (2K, d, J=8.6Hz) APCI-MASS : m/z = 366 (M+H + ) Preparation 321 To a solution of 4-Methoxycarbonylphenylhydroxyimino- methyl chloride (16.98 g) and 4-n-pentyloxyphenylacetylene (18.96 g) in tetrahydrofuran (170 ml) was added triethylamine (14.4 ml) in tetrahydrofuran (14C ml) over a period of 2 hours at 40°C and the mixture was stirred at 40°C for 30 minutes. The mixture was diluted with dichloromethane and washed with water and brine. The separated organic layer was dried over magnesium sulfate and evaporated under reduced pressure. The residue was triturated with acetonitrile. The precipitate was collected by filtration and dried to give Methyl 4- [5- (4-n-pentyloxyphenyl) isoxazol-3-yl]benzoate (24.56 g) . IR (KBr) : 2942, 2873, 1716, 1616, 1508, 1280, 1108 cm "1 NMR (CDC1 3 , δ) : 0.95 (3H, t, J=6.9Hz), 1.3-1.6 (4H, m) , 1.8-2.0 (2H, m) , 3.95 (3H, s), 4.02 (2H, t, J=6.5Hz), 6.74 (IK, s) , 6.99 (2H, d, J=8.8Hz), 7.76 (2H, d, J=8.8Hz), 7.93 (2H, d, J=8.5Hz), 8.14 (2H, d, J=8.5Hz) APCI-MASS : m/z = 366 (M+H r ; Preparation 322 To a solution of N-Hydroxy-4-octyloxybenzamidine (1.89 g) in pyridine (10 ml) was added terephthalic acid monomethyl ester chloride (1.67 g) in tetrahydrofuran (15 ml) dropwise at 0°C. The mixture was stirred at room temperature for 15 minutes, and poured into water. The precipitate was collected by filtration, dried and dissolved in pyridine (10 ml) . The solution was refluxed for 1 hour. The reaction mixture was diluted with ethyl acetate and washed with IN HCl, water and brine. The separated organic layer was dried over magnesium sulfate and the solvents were removed under reduced pressure. The residue was triturated with acetonitrile and collected by filtration. The solid was dried to give Methyl 4- [3- (4-n-hexyloxyphenyl) -1, 2, 4- oxadiazol-5-yl]benzoate (2.27 g) . IR (KBr) : 2950, 2925, 2863, 1720, 1280, 1255 cm "1 NMR (CDC1 3 , δ) : 0.92 (3H, t, J=6.6Hz), 1.2-1.9 (8H, m) , 3.97 (3H, s) , 4.03 (2H, d, J=6.5Hz), 7.00 (2H, d, J=8.9Hz), 8.09 (2H, d, J=8.9Hz), 8.20 (2H, d, J=6.6Hz), 8.28 (2H, d, J=6.6Hz) APCI-MASS : m/z = 381 (M+H) + Preparation 323 A suspension of 1- (4-n-Hexyloxybenzoyl) -2- (4- methoxycarbonylbenzoyl) hydrazine (1.00 g) in phosphorus oxychloride (5 ml) was refluxed for I hour. After cooling, the solution was concentrated under reduced pressure. The residue was poured into ice-water and extracted with dichloromethane. The organic layer was washed with water, brine and dried over magnesiuir sulfate. The solvents were removed under reduced pressure . The residue was triturated with acetonitrile, collected by filtration and dried under reduced pressure to give Methyl 4- [5- (4-n-hexyloxyphenyl) - 1, 3, 4-oxadiazole-2-yl]benzoate (761 mg) . IR (KBr) : 2954, 2854, 1724, 1612, 1494, 1280, 1249 cm "1 NMR (CDC1 3 , δ) : 0.91 (3H, t, J=6.6Hz), 1.3-1.6 (6H, m) , 1.7-1.9 (2H, m) , 3.96 (3H, s) , 4.04 (2H, t, J=6.5Hz), 7.02 (2H, d, J=8.6Hz), 8.07 (2H, d, J=8.6Hz), 8.19 (4H, IT APCI-MASS : m/z = 381 (M+H) " " " The following compounds (Preparations 324 to 327) were obtained according to a similar manner to that of Preparation 323. Preparation 324 Methyl 4- [5- [4- (4-n-propyloxyphenyl)phenyl] -1, 3, 4- oxadiazol-2-yl]benzoate IR (KBr) : 1720, 1614, 1496, 1280, 1103 cm "1 NMR (CDC1 3 , δ) : 1.07 (3H, d, J=7.5Hz), 1.84 (2H, tq, J=6.5 and 7.5Hz), 3.98 (3H, s) , 3.99 (2H, t, J=6.5Hz), 7.01 (2H, d, J=8.8Hz), 7.60 (2H, d, J=8.8Hz), 7.73 (2H, d, J=8.5Hz), 8.19 ' (2H, d, J=8.5Hz), 8.22 (4H, s) APCI-MASS : m/z = 415 (M+H τ ) Preparation 325 Methyl 4- [5- (n-nonyl) -1, 3, 4-oxadiazol-2-yl]benzoate IR (KBr) : 2915, 2848, 1724, 1569, 1436, 1413, 1278 cm "1 NMR (CDC1 3 , δ) : 0.88 (3H, t, J=6.4Hz), 1.2-1.6 (12H, m) , 1.8-2.0 (2H, m) , 2.94 (2H, t, J=7.6Hz), 3.96 (3H, s), 8.11 (2H, d, J=8.8Hz), 8.17 (2H, d, J=8.8Hz) APCI-MASS : m/z = 331 (M+H) ^ Preparation 326 Methyl 4- [5- [4- (8-methoxyoctyloxy)phenyl] -1, 3, 4- oxadiazol-2-yl]benzoate IR (KBr) : 2925, 2858, 1722, 1614, 1280, 1259 cm "1 NMR (CDCI3, δ) : 1.3-1.9 (12H, m) , 3.36 (3H, s), 3.37 (2H, t, J=6.4Hz), 3.97 (3H, s), 4.04 (2H, t, J=6.5Hz), 7.02 (2H, d, J=8.9Hz), 8.07 (2H, d, J=8.9Hz), 8.20 (4H, s) APCI-MASS : m/z = 439 (M+H + ) Preparation 327 Methyl 4- [5- (4-n-octyloxyphenyl) -1, 3, 4-oxadiazol-2- yl1benzoate IR (KBr) : 2923, 2856, 1722, 1614, 1496, 1282, 1103 cm "1 NMR (CDCI3, δ) : 0.89 (3H, t, J=6.8Hz), 1.2-1.6 (10K, m) , 1.7-1.9 (2H, m) , 3.97 (3H, s), 4.04 (2H, t, J=6.5Hz), 7.03 (2H, d, J=8.7Hz), 8.07 (2H, d, J=8.7Hz), 8.19 (4H, m) APCI-MASS : m/z = 409 (M+H + ) Preparation 328 A suspension of 1- (4-Hexyloxybenzoyl) -2- (4- methoxycarbonylbenzoyl)hydrazine (1.0 g) and di-phosphorus pentasulfide (1.28 g) in tetrahydrofuran (15 ml) was stirred at room temperature for 3 hours. The mixture was diluted with water (30 ml) , stirred for 30 minutes and extracted with dichloromethane. The organic layer was washed with brine, dried over magnesium sulfate and evaporated under reduced pressure. The residue was triturated with acetonitrile. The solid was collected by filtration and dried under reduced pressure to give Methyl 4- [5- (4-n-hexyloxyphenyl) -1, 3, 4- thiadiazol-2-yl]benzoate (816 mg) . IR (KBr) : 2925, 2871, 1722, 1608, 1436, 1276, 1106 cm "1 NMR (CDC1 3 , δ) : 0.92 (3H, t, J=6.6Hz), 1.3-2.0 (8H, m) , 3.96 (3H, s), 4.03 (2H, t, J=6.5Hz), 6.99 (2H, d, J=8.6Hz), 7.95 (2H, d, J=8.4Hz), 8.16 (2H, d, J=8.4Hz) APCI-MASS : m/z = 397 (M+H) τ The following compounds (Preparations 329 to 334) were obtained according to a similar manner to that of Preparation 328. Preparation 329 Methyl 4- [5- [4- (8-methoxyoctyloxy) pheny] -1, 3, 4- t' adiazol-2-yl]benzoate IR (KBr) : 3210, 2935, 2856, 1718, 1600, 1465, 1280, 1110 cm "1 NMR (CDCI3, δ) : 1.3-1.6 (10H, m) , 1.7-1.9 (2H, m) , 3.33 (3H, s) , 3.37 (2K, d, J=6.4Hz), 3.96 (3H, s), 4.03 (2H, t, J=6.5Hz), 6.99 (2H, d, J=8.9Hz), 7.94 (2H, d, J=8.9Hz), 8.07 (2H, d, J=8.6Hz), 8.16 (2H, d, J=8.6Hz) APCI-MASS : m/z = 455 (M+H τ ' Preparation 330 Methyl 4- [5- (4-cyclohexylphenyl) -1, 3, 4-thiadiazol-2- yl]benzoate IR (KBr) : 2925, 2850, 1716, 1432, 1274, 1108, 997 cm "1 NMR (CDCI3, δ) : 1.2-1.6 (5H, m) , 1.7-2.0 (5H, m) , 2.58 (IH, m) , 3.96 (3H, s) , 7.34 (2H, d, J=8.2Hz), 7.93 (2H, d, J=8.2Hz), 8.07 (2H, ,d, J=8.6Hz), 8.16 (2H, d, J=8.6Hz) APCI-MASS : m/z = 379 (M+H + ) Preparation 331 Methyl 4- [5- [4- (piperidin-1-y1) phenyl] -1,3, 4-thiadiazol- 2-yl]benzoate IR (KBr) : 2940, 2848, 1720, 1602, 1436, 1415, 1276, 1108 cm "1 NMR (CDC1 3 , δ) : 1.68 (6K, br) , 3.34 (4H, br) , 3.96 (3H, s), 6.95 (2H, d, J=8.7Hz), 7.88 (2K, d, J=8.7Hz), 8.05 (2H, d, J=8.6Hz), 8.16 (2H, d, J=8.6Hz) APCI-MASS : m/z = 380 (M+H + ) Preparation 332 Methyl 4- [5- (4-n-octyloxyphenyl) -1, 3, 4-thiadiazol-2- yl]benzoate IR (KBr) : 2927, 2858, 1720, 1606, 1434, 1276, 1106 cm "1 NMR (CDCI3, δ) : 0.89 (3H, t, J=6.8Hz), 1.2-1.6 (10H, m) , 1.7-1.9 (2H, m) , 3.96 (3H, s) , 4.03 (2H, t, J=6.5Hz), 7.00 (2H, d, J=8.9Hz), 7.95 (2H, d, J=8.9Hz), 8.06 (2H, d, J=8.4Hz), 8.16 (2H, d, J=8.4Hz) APCI-MASS : m/z = 425 (M+H + ) Preparation 333 Methyl 4- [5- (4-trans-n-pentylcyclohexyl) -1, 3, - thiadiazol-2-yl]benzoate IR (KBr) : 2923, 2850, 1722, 1440, 1276, 1110 cm "1 NMR (CDCI3, δ) : 0.89 (3H, t, J=6.9Hz), 1.0-1.8 (13H, m) , 1.92 (2H, d, J=13.4Hz), 2.24 (2H, d, J=12.2Hz), 3.15 (IH, tt, J=12.2 and 3.5Hz), 3.95 (3H, s) , 8.01 (2H, dd, J=8.6 and 2.0Hz), 8.13 (2H, dd, J=8.6 and 2.0Hz) APCI-MASS : m/z = 373 (M+H + ) Preparation 334 Methyl 4- [5- [4- (4-n-propyloxyphenyl)phenyl] -1,3,4- thiadiazol-2-yl]benzoate IR (KBr) : 1720, 1540, 1508, 1282 cm "1 NMR (CDC1 3 , δ) : 1.07 (3H, t, J=7.5Hz), 1.85 (2H, m) , 3.9-4.1 (5H, m) , 7.01 (2H, d, J=8.8Hz), 7.59 (2H, d, J=8.8Hz), 7.70 (2H, d, J=8.4Hz), 8.07 (2H, d, J=8.4Hz), 8.1-8.2 (4H, m) APCI-MASS : m/z = 431 (M+H) + Preparation 335 To a suspension of 4-hexyloxybenzoic acid in oxalyl chloride (10 ml) and dichloromethane (10 ml) was added N,N- dimethylformamide (0.1 ml) . The mixture was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure to give crude 4-hexyloxybenzoyl To a suspension of Ethyl 3-amino-4-hydroxybenzoate (733 mg) and triethylamine (1.38 ml) and 4-dimethylaminopyridine (DMAP, 10 mg) in methylene chloride (10 ml) was added the solution of 4-hexyloxybenzoyl chloride obtained above in dichloromethane (5 ml) dropwise at 10°C. The reaction mixture was stirred at 10°C for 1.5 hours and diluted with dichloromethane (20 ml) . The solution was wa s hed with H2O (20 ml), IN HCl aq. (20 ml x 2) , H 2 0 (20 ml) and brine (20 mi) successively. The organic layer was dried over MgS0 4 and the solvent was removed under reduced pressure. To the residue was added toluene (15 ml) and p-toluenesulfonic acid (10 mg) . The mixture was refluxed for 6 hours and the solvent was removed under reduced pressure. The residue was triturated with acetonitrile, and p-ecipitate was collected with filtration and dried over PO5 to give 2- (4- Hexyloxyphenyl) -5-ethoxycarbonylbenzoxazole (0.60 g) . IR (KBr) : 2952, 2871, 1712, 1623, 1500, 1294, 1255 cm "1 NMR (CDC1 3 , δ) : 0.92 (3H, t, J=6.6Hz), 1.3-1.6 (9H, m) , 1.7-1.9 (2H, m) , 4.05 (2H, t, J=6.5Hz), 4.42 (2H, q, J=7.1Hz), 7.03 (2H, d, J=6.9Hz), 7.57 (IH, d, J=8.6Hz), 8.08 (IK, dd, J=8.6 and 1.7Hz), 8.18 (2H, d, J=6.9Hz), 8.43 (IH, d, J=1.7Hz) APCI-MASS : m/z = 368 (M+H + ) The following compounds (Preparations 336 to 337) were obtained according to a similar manner to that of Preparation 335. Preparation 336 5-Ethoxycarbonyl-2- (2-octyloxypyridin-5-yl) benzoxazole IR (KBr) : 2933, 2858, 1716, 1623, 1604, 1577, 1467, 1290, 1213, 1083 cm "1 NMR (CDCI3, δ) : 0.89 (3H, t, J=6.7Hz), 1.2-1.5 (10H, m) , 1.43 (3H, t, J=7.1Hz), 1.7-1.9 (2H, m) , 4.3-4.5 (4H, m) , 6.87 (IH, d, J=8.7Hz), 7.60 (IH, d, J=8.6Hz), 8.11 (IK, dd, J=8.6 and 1.6Hz), 8.37 (IH, dd, J=8.8 and 2.4Hz), 8.45 (IH, d, J=1.6Hz), 9.03 (IH, d, J=2.4Hz) APCI-MASS : m/z = 397 (M+H + ) Preparation 337 2- [4- (4-Hexylphenyl)phenyl] -5-ethoxycarbonylbenzoxazole IR (KBr) : 2952, 2871, 1712, 1623, 1500, 1294, 1255, 1024 cm "1 NMR (CDCI3, δ) : 0.90 (3K, t, J=6.6Hz), 1.2-1.5 (6H, m) , 1.44 (3H, t, J=7.1Hz), 1.6-1.8 (2H, m) , 2.67 (2H, t, J=7.3Hz), 4.43 (2H, q, J=7.1Hz), 7.27 (IH, d, J=3.7Hz), 7.32 (IH, s), 7.5-7.7 (3H, m) , 7.77 (2H, d, J=8.6Hz), 8.12 (IH, dd, J=8.6 and 1.7Hz), 8.32 (2H, a, J=8.5Hz), 8.48 (IH, d, J=1.2Hz) APCI-MASS : m/z = 428 (M+H + ) Preparation ?18 A suspension of 4- [4- (8-bromooctyloxy)phenyl]benzoic acid (1 g) in 2, 6-dimethylmorpholine (3.06 ml) was refluxed for 30 minutes. The reaction mixture was added to a mixture of water and ethyl acetate and adjusted to pH 2.0 with cone. HCl. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 4-[4- [8- (2, 6-dimethylmorpholin-4-yl)octyloxy]phenyl]benzoic acid hydrochloride (0.95 g) . IR (KBr) : 2939.0, 1704.8, 1606.4, 1189.9 cm "1 NMR (DMSO-dg, δ) : 1.12 (6H, d, J=6.3Hz), 1.2-1.6 (10H, m) , 1.6-1.9 (4H, m) , 2.4-2.7 (2H, ) , .9-3.1 (2H, m) , 3.8-4.0 (2H, ) , 4.02 (2H, t, J=6.3Hz), 7.04 (2H, d, J=8.8Hz), 7.68 (2H, d, J=8.8Hz), 7.75 (2H, d, J=8.4Hz), 7.99 (2H, d, J=8.4Hz) APCI-MASS : m/z = 440 (M+H + ) Preparation 39 Sodium hydride (60? suspension in mineral oil, 108 mg) was added to ethoxyethanol (10 ml), and the solution was stirred at 60°C for 20 minutes. To the solution was added Methyl 4-[4- (8-bromooctyloxy)phenyl] enzoate (1.26 g) , and the reaction mixture was stirred at 70°C for 2 hours. To the reaction mixture was added 10 ς: > sodium hydroxide aqueous solution (2.4 ml), and the solution was stirred at 70°C fcr 1 hour. After cooling, the solution was adjusted to pH 2.0 with IN hydrochloric acid. The precipitate was collected by filtration, and dried to give 4- [4-[8- (2- Ethoxyethoxy)octyloxy]phenyl] enzoic acid (1.13 g) . IR (KBr) : 2933, 2858, 1685, 1604, 1434, 1294, 1132 cm -1 NMR (DMSO-dg, δ) : 1.09 (3H, t, J=7.0Hz), 1.2-1 Q (14H, m), 3.2-3.6 (6H, m) , 4.01 (2H, d, J=6.3Hz), 7.04 (2H, d, J=8.8Hz), 7.67 (2H, d, J=8.8Hz), 7.74 (2H, d, J=8.5Hz), 7.98 (2H, d, J=8.5Hz) APCI-MASS : m/z = 415 (M+H + ) The following compound was obtained according to a similar manner to that of Preparation 300. Preparation 340 4-n-Pentyloxybenzoylhydrazine IR (KBr) : 3182, 2937, 2869, 1645, 1618, 1571, 1251 cm "1 NMR (DMSO-dg, δ) : 0.89 (3H, d, J=7.1Hz), 1.2-1.8 (6K, m) , 4.00 (2H, t, J=6.5Hz), 4.41 (2H, s), 6.96 (2H, d, J=8.8Hz), 7.78 (2H, d, J=8.8Hz), 9.59 (IH, s) APCI-MASS : m/z = 223 (M+H + ) The following compound was obtained according to a similar manner to that of Preparation 291. Preparation 341 1- (4-Methoxycarbonylbenzoyl) -2- (4-n-pentyloxybenzoyl) - hydrazine IR (KBr) : 3234, 2956, 2931, 1724, 1683, 1643, 1610, 1284, 1253 cm "1 NMR (DMSO-dg, δ) : 0.90 (3H, t, J=6.9Hz), 1.2-1.5 (4H, m) , 1.6-1.8 (2H, m) , 3.90 (3H, s) , 4.04 (2H, t, J=6.5Hz), 7.04 (2H, d, J=8.8Hz), 7.90 (2H, d, J=8.8Hz), 8.03 (2H, d, J=8.7Hz), 8.10 (2H, d, J=8.7H " z), 10.42 (IH, s) , 10.64 (IH, s) APCI-MASS : m/z = 385 (M+H + ) The following compound was obtained according to a similar manner to that of Preparation 328. Preparation 342 Methyl 4- [5- (4-n-pentyloxyphenyl! th adiazci-2- yl]benzoate IR (KBr) : 2940, 2871, 1720, 1606, 1438, 1280 cm "1 NMR (CDC1 3 , δ) : 0.95 (3H, t , J=7.1Hz), 1.3-1.6 (4H, m) , 1.8-2.0 (2H, m) , 3.96 (3K, s), 4.03 (2K, t, J=6.5Hz), 6.99 (2H, d, J=8.8Hz), 7.94 (2H, d, J=8.8Hz), 8.06 (2H, d, J=8.7Hz), 8.16 (2H, d, J=8.7Hz) APCI-MASS : m/z = 383 (M÷H ÷ ) The following compound was obtained according to a similar manner to that of Preparation 32 Preparation 343 4- [5- (4-n-Pentyloxyphenyl) thiadiazol-2-yljbenzoic acid IR (KBr) : 2954, 2867, 1687, 1602, 1432, 1294, 1255 cm -1 NMR (DMSO-dg, δ) : 0.91 (3K, t, J=7.0Hz), 1.3-1.5 (4H, m) , 1.7-1.9 (2H, m) , 4.07 (2H, t, J=6.7Hz), 7.13 (2H, d, J=8.8Hz), 7.97 (2H, d, J=8.8Hz), 8.07 (4H, s) APCI-MASS : m/z = 369 (M÷H + ) The following compound was obtained according to a similar manner to that of Preparation 49. Preparation 344 1- [4- [5- (4-n-Pentyloxypher. ;hiadiazol-2-yl]benzoyl] - benzotriazole 3-oxide IR (KBr) : 2948, 2873, 1770, 1602, 1257, 1232 cm "1 NMR (CDC1 3 , δ) : 0.95 (3K, t, J=7.1Hz), 1.3-1.6 (4H, m) , 1.8-2.0 (2H, ) , 4.04 (2H, z , J=6.5Hz), 7.01 (2H, d, J=8.1Hz), 7.4-7.7 (3H, mj , 7.97 (2H, d, J=8.1Hz), 8.12 (IH, d, J=8.2Hz), 3.24 (2H, d. J=8.0Hz), 8.40 (2H, d, J=8.0Hz) APCI-MASS : m/z = 486 (M+K + ) Preparation 345 To a solution of 4-bromobenzaldehyde oxime chloride (647 mg) and 4-n-pentyloxy-phenylacetylene (650 mg) in tetrahydrofuran (7 ml) was added triethylamine (0.5 ml) in tetrahydrofuran (5 ml) dropwise at 40°C. The solution was stirred at 40°C for 30 minutes, poured into water and extracted with ethyl acetate. The organic layer was washed with H 2 0, brine and dried over magnesium sulfate. The solvents were removed under reduced pressure and the residue was triturated with acetonitrile. The precipitate was collected by filtration and dried to give 4-[5-(4-n- pentyloxyphenyl) isoxazol-3-yl]bromobenzene (0.59 g) . IR (KBr) : 2948, 2867, 1612, 1430, 1255 cm "1 NMR (CDC1 3 , δ) : 0.95 (3H, t, J=6.9Hz), 1.3-1.6 (4H, m) , 1.7-1.9 (2H, m) , 4.01 (2H, t, J=6.5Hz), 6.66 (IH, s), 6.98 (2H, d, J=8.8Hz), 7.60 (2H, d, J=8.6Hz), 7.7-7.9 (4K, m) APCI-MASS : m/z = 388 (M+K + ) Preparation 346 To a suspension of 4- [5- (4-n-pentyloxyphenyl) isoxazol-3- yl]bromobenzene (386 mg) in tetrahydrofuran (5 ml) was added 1.55M n-butyllithium in hexane (0.84 ml) at -40°C under N 2 stream and the solution was stirred for 1 hour at -40°C. To the solution was added crushed dryice (1 g) and the suspension was stirred for 1 hour at -40°C. The suspension was diluted with H 7 0, and acidified with IN-hydrochloric acid. The precipitate was collected by filtration and dried to give 4- [5- (4-n-pentyloxyphenyl) isoxazol-3-yl]benzoic acid (312 mg) . IR (KBr) : 2939, 2867, 1681, 1614, 1429, 1255, 1178, 821 cm "1 NMR (DMSO-dg, δ) : 0.91 (3H, t, J=7.1Hz) , 1.3-1.5 (4H, m) , 1.6-1.8 (2H, m) , 4.04 (2H, _, J=6.5Hz), 7.11 (2H, d, J=8.9Hz), 7.54 (IH, s) , 7.85 (2H, d, J=8.9Hz), 7.98 (2H, d, J=8.6Hz), 8.11 (2H, d, J=8.6Hz) APCI-MASS : m/z = 352 (M-H + ; The Starting Compound in the following Examples 1 to 117 and The Object Compounds (1) to (122) and (124) in the following Examples 1 to 122 and 124 are illustrated by chemical formulae as below. The Starting Compound (the same in Examples 1 to 117) The Object Compounds (1) to (122) and (124) In the following Examples, The Object Compound (X) [e.g. The Object Compound (1) ] means the object compound of Example (X) [e.g. Example (l) j . 11210 - 168 - Example No ( H 2>6 CH 3 11210 - 169 - 210 178 - 1210 - 179 - 210 - 181 - 11210 - 184 - Example No. The Object Compound 123 Exampl e 1 To a solution of The Starting Compound (1 g) and 1- (6-octyl-oxymethylpicolinoyl)benzotriazole 3-oxide (0.399 g) in N,N-dimethylformamide (10 mi) was added 4-(N,N- dimethvlamino)pyridine (0.140 g) , and stirred for 12 hours at ambient temperature. The reaction mixture was pulverized with ethyl acetate. The precipitate was collected by filtration, and dried under reduced pressure. The powder was dissolved in water, and subjected to coi "" .mn chromatography on ion exchange resin (DO EX-50WX4 (Trademark : prepared by Dow Chemical) ) eluting with water. The fractions containing the object compound were combined, and subjected to column chromatography on OD3 (YMC-gelODS-AM-S-50) (Trademark : prepared by Yamamura Chemical Lab.) eluting with 50' " . methanol aqueous solution. The fractions containing the object compound were combined, and evaporated under reduced pressure to remove methanol. The residue was lyophiiized to give The Object Compound (1) . IR (KBr) : 3347, 1664, 1629, 1517 cm "1 NMR (DMSO-d 6 , δ) : 0.86 (3H, t, J=6.7Hz), 0.98 (3H, d, J=6.7Hz), 1.09 (3H, d, J=6.0Hz) , 1.2-1.47 (10H, m) , 1.47-1.67 (2H, m) , 1.67-2.06 (3H, m) , 2.06-2.5 (4H, m) , 3.19 (IH, m) , 3.53 (2H, t, J=6.4Hz), 3.5-3.85 { 2 ' ή, m) , 3.85-4.7 (13H, m) , 5.35 (11H, m) , 5.56 (IK, d, J=5.7Hz), 6.73 (IH, d, J=8.3Hz), 6.83 (IH, d, J=8.3Hz), 6.89 (IH, s), 7.05 (IH, s), 7.11 (IH, s) , 7.32 (IH, m) , 7.43 (IH, d, J=8.5Hz), 7.63 (IH, d, J=7.3Hz), 7.85-8.13 (4H, m) , 8.66 (IH, d, J=7.8Hz), 8.84 (IH, s) FAB-MASS : m/z = 1228 (M + +Na) » Elemental Analysis Calcd. for C5oH 2Ngθ22 SNa '6 H 2θ : C 45.49, H 6.44, N 9.59 Found : C 45.89, H 6.52, N 9.69 The Object Compounds (2) to (25 ) were obtained according to a similar manner to that of Example 1. Example 2 IR (KBr) : 3353, 1666, 151C, 1236 cm "1 NMR (DMS0-d 6 , δ) : 0.86 (3H, t, J=ό.7H∑), 0.96 (3H, d, J=6.7Hz), 1.06 (3H, d, J=5.8Hz), 1.2-1.5 (10H, m) , 1.55-2.05 (5H, m) , 2.11-2.7 (4H, m) , 3.0-3.3 (5H, m) , 3.3-3.5 (4H, m) , 3.6-4.5 (15H, nt) , 4.6-5.6 (12H, m) , 6.6-7.2 (10H, m) , 7.2-7.5 (3H, m) , 7.81 (2H, d, J=S.8Hz), 8.05 (IH, d, J=8.7Hz), 8.28 (IH, d, J=8.7Hz), 8.41 (IH, d, J=6.7Hz), 8.84 (IH, s) FAB-MASS : m/z = 1373 (M + +Na) Elemental Analysis Calcd. for C6gHg3N2oC > 22 SNa '4 H 2 0 : C 50.63, H 6.44, N 9.84 Found : C 50.59, H 6.59, N 9.79 Example 3 IR (KBr) : 3350, 1664, 1627, 1047 cm "1 NMR (DMS0-d 6 , δ) : 0.96 (3H, d, J=6.6Hz), 1.08 (3H, d, J=5.7Hz), 1.15-1.53 (8H, ) , 1.55-2.1 (9H, m) , 2.1-2.45 (3H, ) , 2.5-2.7 (IH, m) , 3.18 (IH, m) , 3.6-3.83 (2H, m) , 3.83-4.6 (17H, m) , 4.7-5.4 (11H, m) , 5.51 (IH, d, J=5.9Hz), 6.73 (IH, d, J=8.2Hz), 6.83 (IH, d, J=8.2Hz), 6.85 (IH, s) , 7.03 (2H, d, J=8.4Hz), 7.05 (IH, s) , 7.30 (IH, s), 7.2-7.5 (2H, m) , 7.67 (2H, d, J=8.4Hz), 7.71 (2H, d, J=7.4Hz), 7.94 (IH, s) , 7.96 (2H, d, J=7.4Hz), 8.06 (IH, d, J=8.0Hz), 8.25 (IH, d, J=6.7Hz), 8.50 (IH, s) , 8.74 (IH, d, J=6.7Hz), 8.84 (IH, s) FAB-MASS : m/z = 1356 (M + +Na) Elemental Analysis Calcd. for C59H7 6 N 11 θ22SNa-4H 2 0 : C 49.53, H 6.02, N 10.95 Found : C 49.26, H 6.22, N 10.77 Example 4 IR (KBr) : 3350, 1660, 1631, 1047 cm "1 NMR (DMSO-d 6 , δ) : 0.86 (3H, t, J=6.9Hz, , 0.97 (3h, d, J=6.6Hz), 1.09 (3H, d, u=5.3Hz), 1.2-1.5 (10H, m) , 1.37 (6H, s), 1.55-2.0 (5H, m) , 2.1- 2.6 (4H, m) , 3.16 (IH, m) , 3.73 (2H, m) , 3.89 (2H, t, J=6.3Hz), 3.95-4.49 (11H, ) , 4.68-5.21 (10H, m) , 5.25 (IH, d, J=4.1Hz), 5.53 (IH, d, J=5.7Hz), 6.73 (IH, d, J=δ.2Hz), 6.75-6.85 (4H, m) , 6.91 (IH, d, J=8.2Hz), 7.05 (IH, s) , 7.15 (IH, s), 7.3-7.5 (2H, m) , 7.9-8.2 (3H, m) , 8.84 (IH, s) FAB-MASS : m/z = 1271 (M + +Na) Elemental Analysis Calcd. For C53H77Ngθ23S a-4H2θ : C 48.18, H 6.48, N 8.48 Found : C 48.04, E 6.51, N 8.38 Example 5 IR (KBr) : 1666, 1629, 1222 cm "1 NMR (DMSO-d 6 , δ) : 0.85 (3H, t, J=6.6Hz), 0.9-1.12 (6H, ) , 1.12-1.52 (13H, ) , 1.52-1.93 (5H, ) , 2.08-2.55 (4H, m) , 3.1*6 (IH, m) , 3.6-5.3 (26H, m) , 5.49 + 5.54 (IH, d, J=5.8Hz, mixture of diastereomer) , 6.60-7.1 (7H, m) , 7.04 (IH, s) , 7.1 (IH, m) , 7.2-7.5 (2H, m) , 7.9-8.43 (3H, ) , 8.83 (IH, s) FAB-MASS : m/z = 1257 (M + +Na) Elemental Analysis Calcd. for C52H75iJgθ23SNa-3H2θ : C 48.44, H 6.33, N 8.69 Found : C 48.16, H 6.51, N 8.53 Example 6 IR (KBr) : 3349, 1666, 1629, 1259 cm "1 NMR (DMSO-d 6 , δ) : 0.86 (3H, t, J=6.7Hz), 0.9 (3H, d, J=5.7Hz), 0.96 (3H, d, J=6.7Hz), 1.1-1.55 (19H, m) , 1.55-2.0 (5H, m) , 2.0-2.47 (4H, m) , 2.65-3.25 (3H, m) , 3.5-5.13 (27H, m) , 5.17 (IH, d, J=3.2Hz), 5.24 (IH, d, J=4.5Hz), 5.38 (IH, d, J=5.9Hz), 6.5-6.9 (5H, m) , 6.9-7.1 (3H, ) , 7.2- 7.46 (2H, m) , 7.7-8.1 (3H, m) , 8.83 (IH, s) FAB-MASS : m/z = 1368 (M + +Na) Elemental Analysis Calcd. for C58Hg 4 N9θ 2 SNa*5H2θ : C 48.50, N 6.60, N 8.78 Found : C 48.47, H 6.83, N 8.78 Example 7 IR (KBr) : 3350, 1666, 1502, 1199 cm "1 NMR (DMSO-d 6 , δ) : 0.86 (3H, t, J=6.6Hz), 0.97 (3H, d, J=6.7Hz), 1.06 (3H, d, J=5.7Hz), 1.2-1.5 (10H, m) , 1.55-2.0 (5H, m) , 2.1-2.6 (4H, m) , 3.17 (IH, m) , 3.7-4.5 (15H, m) , 4.7-5.22 (10H, m) , 5.24 (IH, d, J=4.4Hz), 5.60 (IH, d, J=5.9Hz), 6.68-7.03 (8H, m) , 7.04 (IH, s), 7.2- 7.42 (2H, m) , 7.85-8.1 (3H, ) , 8.83 (IH, s) FAB-MASS : m/z = 1229 (M + +Na) Elemental Analysis Calcd. for C5 Q H7 Ngθ23SNa*5H2θ : C 46.29, H 6.29, N 8.64 Found : C 46.39, H 6.05, N 8.72 Example 8 IR (KBr) : 3350, 1666, 1631, 1513 cm "1 NMR (DMSO-d 6 , δ) : 0.88 (3H, t, J=6.2Hz), 0.97 (3H, d, J=6.7Hz), 1.04 (3H, d, J=5.7Hz), 1.2-1.58 (8H, m) , 1.58-2.0 (5H, m) , 2.0-2.6 (4H, m) , 3.17 (IH, m) , 3.6-4.5 (15H, m) , 4.63-5.33 (13H, ) , 5.53 (IH, d, J=5.9Hz), 6.73 (IH, d, J=8.2Hz), 6.82 (IH, d, J=8.2Hz), 6.84 (IH, s), 6.95-7.52 (7H, m) , 7.66 (IH, d, J=7.6Hz), 7.7-7.9 (3H, m) , /11210 - 190 - 8.05 (IH, d, J=9.1Hz), 8.15 (IH, d, J=7.6Hz), 8.85 (IH, s) FAB-MASS : m/z = 1279 (M + +Na) Elemental Analysis Calcd. for C5 4 H73N 8 θ23SNa*5H2θ : C 48.14, H 6.21, N 8.32 Found : C 48.43, H 6.28, N 8.30 Example 9 IR (KBr) : 3347, 2956, 1664, 16: , 1508, 1444, 1268, 1047 cm "1 NMR (DMSO-d 6 , δ) : 0.9-1.1 (SH, ) , 1.06 (3H, d, J=5.9Hz), 1.3-1.5 (8K, ) , 1.6-2.0 (7H, m) , 2.1- 2.4 (3H, m) , 2.5-2.6 (IH, m) , 3.1-3.3 (IH, m) , 3.6-4.4 (17H, m) , 4.7-5.0 (8H, ) , 5.09 (IH, d, J=5.5Hz), 5.16 (IH, d, J=3.1Hz), 5.24 (IH, d, J=4.5Hz), 6.73 (IH, d, J=8.2Hz), 6.8-6.9 (2H, m) , 6.98 (IH, d, J=8.3Hz), 7.05 (IH, d, J=1.7Hz), 7.3-7.6 (5H, m) , 8.08 (IH, d, J=8.9Hz), 8.25 (IH, d, J=8.4Hz), 8.54 (IK, d, J=7.5Hz), 8.83 (IK, s) FAB-MASS : m/z = 1257 (M + +Na) Elemental Analysis Calcd. for C5 2 H75Ngθ23SNa*4H2θ : C 47.78, H 6.40, N 8.57 Found : C 47.88, H 6.71, N 8.53 Example 10 IR (KBr) : 3350, 291,, 1664, 1625, 1529, 1440, 1276, 1226, 1047 cm "1 NMR (DMSO-d 6 , δ) : 0.86 (3H, t, J=6.8Hz) , 0.97 (3H, d, =6.7Hz), 1.12 (3H, d, J=5.9Hz), 1.2-1.5 (10H, m) , 1.6-2.1 (5H, m) , 2.1-2.4 (4H, m) , 3.1- 3.3 (IH, m) , 3.5-4.6 (15H, m) , 4.7-5.0 (3H, m) , 5.0-5.2 (7H, ) , 5.27 (IH, d, J=4.4Hz), 5.55 (IH, d, J=5.7Hz), 6.73 (IH, d, J=8.2Hz), 6.8-7.0 (2H, m), 7.0-7.2 (4H, m) , 7.3-7.6 (2H, m) , 7.90 (IH, d, J=8.8Hz), 8.0-8.2 (2H, m) , 8.8-8.9 (2H, m) , 9.06 (IH, d, J=7.2Hz) FAB-MASS : m/z = 1281 (M + +Na) Elemental Analysis Calcd. for C53H7 1 N 8 θ2 SNa*5H 0 : C 47.18, H 6.05, N 8.30 Found : C 46.97, H 6.27, N 8.22 Example n NMR (DMSO-d 6 , δ) : 0.87-1.05 (6H, m) , 1.10 (3H, d, J=5.7Hz), 1.3-1.5 (_H, m) , 1.6-1.9 (5H, m) , 2.2- 2.5 (3H, ) , 2.6 (IH, m) , 3.1-3.2 (IH, m) , 3.7- 4.5 (15H, m) , 4.8-5.1 (8H, m) , 5.09 (IH, d, J=5.64Hz), 5.16 (IH, d, J=3.2Hz), 5.26 (IH, d, J=4.2Hz), 5.52 (IH, d, J=6.0Hz), 6.73 (2H, d, J=8.4Hz), 6.8-6.9 (2H, m) , 7.0-7.1 (3H, m) , 7.2- 7.4 (4H, m) , 7.6-7.8 (6H, m) , 8.11 (IH, d, J=8.4Hz), 8.29 (IH, d, J=8.4Hz), 8.51 (IH, d, J=7.7Hz), 8.85 (IH, s) FAB-MASS : m/z = 1273 (M + +Na) Elemental Analysis Calcd. for C55H7- j _N 8 θ22SNa*4H2θ : C 49.92, H 6.02, N 8.47 Found : C 49.79, H 6.14, N 8.45 Example 12 IR (KBr) : 3330, 2929, 1670, 1629, 1533, 1440, 1280, 1226, 1045, 804 cm "1 NMR (DMSO-d 6 , δ) : 0.86 (3H, t, J=6.7Hz), 0.97 (3H, d, J=6.7Hz), 1.08 (3H, d, J=5.9Hz), 1.2-1.6 (10H, m) , 1.6-2.0 (5H, m) , 2.1-2.5 (4H, m) , 3.1- 3.3 (IH, m) , 3.6-4.5 (15H, m) , 4.8-5.1 (9H, m) , 5.17 (IH, d, J=3.0Hz), 5.25 (IH, d, J=4.5Hz), 5.56 (IH, d, J=5.6Hz), 6.73 (IH, d, J=8.2Hz), 6.83 (IH, d, J=6.8Hz), 7.1-7.2 (3H, m) , 7.3-7.5 (3H, m) , 7.85 (IH, d, J=8.8Hz), 8.0-8.2 (3H, m) , 8.84 (IH, s), 8.96 (IH, d, J=7.2Hz) FAB-MASS : m/z = 1269 (M + +Na) Elemental Analysis Calcd. for C52H 71 N 8 θ22S2 Na "' 3H 2 0 : C 47.34, H 6.04, N 8.49 Found : C 47.21, H 5.96, N 8.41 Example 13 IR (KBr) : 3345, 2927, 1664, 1629, 1515, 1442, 1274, 1047 cm "1 NMR (DMSO-d 6 , δ) : 0.85 (3H, t, J=6.7Hz), 0.97 (3H, d, J=6.7Hz), 1.10 (3H, d, J=5.9Hz), 1.2-1.4 (10H, m) , 1.5-2.5 (8H, m) , 2.46 (3H, s), 2.69 (2H, t, J=7.7Hz), 3.1-3.4 (2H, m) , 3.6-4.5 (17K, m) , 4.8-5.2 (8H, m) , 6.7-7.0 (3H, m) , 7.05 (IH, d, J=1.7Hz), 7.14 (IH, s), 7.3-7.6 (5H, m) , 8.0- 8.2 (2H, m) , 8.47 (IH, d, J=7.0Hz), 8.84 (IH, s) FAB-MASS : m/z = 1251 (M + +Na) Elemental Analysis Calcd. for C53H73 8 022 SNa "3H 2 0 : C 49.61, H 6.21, N 8.73 Found : C 49.88, H 6.44, N 8.74 Example 14 IR (KBr) : 3340, 1672, 1627, 1542, 1513, 1440, 1268, 1045 cm "1 NMF " JMSO-d 6 , δ) : 0.84 (3H, t, J=6.7Hz), 0.94 (3H, d, J=6.7Hz), 1.07 (3H, d, J=6.0Hz), 1.2-1.4 (12H, m) , 1.6-2.0 (5H, ) , 2.1-2.4 (3H, m) , 2.6 (IH, m) , 2.96 (2H, t, J=7.4Hz), 3.1-3.3 (IH, m) , 3.6-4.5 (13H, ) , 4.7-5.2 (11H, m) , 5.50 (IH, d, J=5.7Hz), 6.73 (IH, d, :=8.2Hz), 6.8-6.9 (2H, m) , 7.04 (IK, s), 7.2-7. (3H, ) , 7.72 (IH, d, J=8.5Hz), 7.91 (IH, d, J=8.4Hz), 8.05 (IH, d, J=8.4Hz), 8.2-8.4 (IH, m) , 8.80 (IH, d, J=7.7Hz), 8.83 (IH, s) FAB-MASS : m/z = 1252 (M + +Na) Elemental Analysis Calcd. for 052^2^022*3^*6^0 : C 46 . 67 , H 6 . 33 , N 9 . 42 Found : C 46 . 72 , H 6 . 53 , N 9 . 45 Example 15 IR (KBr) : 3350, 2935, 1664, 1627, 1517, 1446, 1251, 1045 cm "1 NMR (DMSO-d 6 , δ) : 0.90-1.1 (6H, m) , 1.10 (3H, d, J=5.9Hz), 1.2-1.4 (6H, m) , 1.6-2.4 (8H, m) , 2.6- 2.7 (IH, m) , 3.1-3.3 (IH, m) , 3.7-4.5 (16H, m) , 4.7-5.4 (11H, m) , 5.51 (IH, d, J=5.6Hz), 6.7-7.0 (3H, m) , 7.0-7.6 (7H, m) , 7.74 (IH, d, J=8.6Hz), 8.0-8.4 (5H, m) , 8.7-8.8 (IH, m) , 8.84 (IH, s; FAB-MASS : m/z = 1301 (M ÷ +Na) Elemental Analysis Calcd. for C55H 71 N oθ22 SNa ' 6H 2° : C 47.62, H 6.03, N 10.01 Found : C 47.65, H 6.03, N 10.03 Example 16 IR (Nujol) : 3353, 1668, 162 , 1540, 1515, 1500 cm "1 NMR (DMSO-d 6 , δ) : 0.80-1.00 (6H, m) , 1.06 (3H, d, J=5.9Hz), 1.20-1.53 (4H, m) , 1.60-1.95 (5H, ) , 2.00-2.65 (8H, m) , 2.80 (2H, t, J=7.5Hz), 3.05- 3.45 (IH, m) , 3.50-3.85 (2H, m) , 3.90-4.48 (11H, m) , 4.65-5.38 (11H, ) , 5.47 (IH, d, J=6.0Hz), 6.65-6.90 (2H, m) , 6.90-7.10 (2H, m) , 7.10-7.65 (11H, m) , 7.90-8.25 (2H, m) , 8.30 (IK, d, J=7.8Hz), 8.84 (IH, s) FAB-MASS : m/z = 1275.3 (M + +Na) Elemental Analysis Calcd. for C55H73Ngθ22 SNa ' 3H 2° : C 50.53, H 6.09, N 8.57 Found : C 50.48, H 6.39, N 8.57 Example 7 IR (Nujol) : 3351, 1656, 1623, 1538, 1515 cm "1 NMR (DMSO-d 6 , δ) : 0.86 (3H, t, J=6.7Hz), 0.96 (3H, d, J=6.7Hz), 1.08 (3H, d, J=5.8Hz) , 1.15-1.40 (8H, m) , 1.50-2.00 (5H, ) , 2.10-2.48 (4H, m) , 2.52-2.70 (2H, m) , 3.05-3.2& (IH, m) , 3.60-4.50 (13H, m) , 4.70-5.20 (9H, m) , 5.25 (IH, d, J=4.6Hz), 5.52 (IH, d, J=6.0Hz) , 6.68-6.92 (4H, m) , 7.04 (IH, d, J=1.0Hz), 7.22-7.50 (5H, m) , 7.55-7.82 (7H, m) , 8.14 (IH, d, J=8.4Hz) , 8.31 (IH, d, J=8.4Hz), 8.54 (IH, d, J=7.7Hz), 8.84 (IK, s) FAB-MASS : m/z = 1285 (M τ +Na) Example 18 IR (Nujol) : 3351, 1668, 1627, 1540, 1515 cm "1 NMR (DMSO-d 6 , δ) : 0.87 (3H, t, J=6.8Hz), 0.96 (3H, d, J=6.7Hz), 1.06 (3H, d, J=5.8Hz), 1.17-1.48 (4H, ) , 1.50-1.95 (5H, m) , 2.05-2.70 (8H, m) , 2.70-2.95 (2H, m) , 3.05-3.30 (IH, m) , 3.60-3.90 (2H, m) , 3.90-4.50 (11H, m) , 4.65-5.10 (9H, m) , 5.15 (IK, d, J=3.2Hz), 5.23 (IH, d, J=4.2Hz), 5.48 (IH, d, J=6.0Hz), 6.67-6.90 (3H, m) , 7.03 (IH, d, J=1.5Hz), 7.15-7.80 (11H, m) , 8.00-8.20 (2H, m) , 8.29 (IH, d, J= " ..8Hz), 8.84 (IK, s) FAB-MASS : m/z = 1259 (M + +Na) Elemental Analysis Calcd. for C55H7 3 N 8 θ2iSNa-6H 2 0 : C 50.30, H 6.52, N 8.53 Found : C 50.42, H 6.50, N 6.45 Example 19 IR (Nujol) : 3351, 1668, 1652, 1623, 1540 cm "1 NMR (DMSO-d 6 , δ) : 0.87 (3H, t, J=6.7Hz), 0.96 (3H, d, J=6.7Hz), 1.07 (3H, d, J=6.0Hz), 1.25-1.45 (4H, m) , 1.50-2.00 (5H, m) , 2.05-2.48 (4H, m) , 2.50-2.75 (2H, m) , 3.60-4.50 (13H, m) , 4.68-5.25 (10H, m) , 5.27 (IH, d, J=4.5Hz), 5.53 (IH, d, J=6.0Hz), 6.67-6.98 (4H, m) , 7.05 (IH, d. J=1.0Hz), 7.22-7.58 (5H, m) , 7.58-7.90 (7H, ) , 8.16 (IH, d, J=9.0Hz), 8.34 (IH, d, J=8.4Hz), 8.57 (IK, d, J=7.7Hz), 8.85 (IH, s) FAB-MASS : m/z = 1258 (M + +Na) Elemental Analysis Calcd. for C55H7- j _N θ2iSNa*5H2θ : C 49.84, H 6.15, N 8.45 Found : C 49.77, H 6.27, N 8.39 Example 20 IR (Nujol) : 3353, 1670, 1629, 1540, 1508 cm "1 NMR (DMSO-d 6 , δ) : 0.88 (3H, t, J=6.5Hz), 0.97 (3H, d, J=6.8Hz), 1.04 (3H, d, J=5.9Hz), 1.20-1.58 (8H, m) , 1.60-1.96 (5H, m) , 2.08-2.60 (6H, m) , 2.70-3.00 (2K, m) , 3.00-3.40 (IH, m) , 3.60-3.85 (2H, m) , 3.85-4.50 (13H, m) , 4.50-5.60 (12H, m) , 6.65-6.90 (3H, m) , 7.00-7.15 (3H, m) , 7.18-7.50 (4H, m) , 7.59 (IH, s), 7.62-7.78 (2H, m) , 7.95- 8.20 (2H, m) , 8.30 (IH, d, J=7.7Kz), 8.83 (IH, s) FAB-MASS : m/z = 1277 (M + +Na) Elemental Analysis Calcd. for C55H75N 8 θ22S a-4H 2 0 : C 49.77, H 6.30, N 6.44 Found : C 49.67, H 6.31, N 8.40 Example 21 IR (Nujol) : 3351, 1654, 1623, 1538, 1515 cm "1 NMR (DMSO-d 6 , δ) : 0.87 (3H, t, J=6.7Hz), 0.97 (3H, d, J=6.7Hz), 1.08 (3H, d, J=5.9Hz), 1.20-1.58 (8H, m) , 1.66-1.95 (5H, m) , 2.10-2.60 (4K, m) , 3.09-3.30 (IH, m) , 3.58-4.60 (15H, m) , 4.69-5.20 (10H, m) , 5.24 (IH, d, J=4.5Hz), 5.51 (IH, d, J=6.0Hz), 6.68-6.95 (4H, m) , 7.04 (IH, d, J=1.0Hz), 7.10-7.73 (7H, m) , 7.73-7.90 (2H, m) , 7.98 (IH, d, J=1.9Hz), 8.10 (IH, d, J=8.4Hz), 8.32 (IH, d, J=8.4Hz), 8.50 (IH, d, J=7.7Hz), 8.84 (IH, s) FAB-MASS : m/z = 1275 (M + +Na) Elemental Analysis Calcd. for C55H73Ngθ22SNa*5H 2 0 : C 50.38, H 6.38, N 8.55 Found : C 49.98, K 6.37, N 8.41 Example 22 IR (KBr) : 3340, 2931, 1664, 1627, 1531, 1444, 1276, 1047 cm "1 NMR (DMSO-d 6 , δ) : 0.86 (3H, t, J=6.6Hz), 0.96 (3H, d, J=6.8Hz), 1.08 (3H, d, J=5.9Hz), 1.2-1.4 (6K, m) , 1.5-1.7 (2H, m) , 1.7-2.1 (3H, m) , 2.2-2.4 (3H. m) , 2.6-2.7 (3H, m) , 3.1-3.2 (IH, m) , 3.7- 4.6 .13H, m) , 4.78 (IH, d, J=6.0Hz), 4.8-5.1 (IH, m) , 5.09 (IH, d, J=5.6Hz), 5.16 (IH, d, J=3.2Hz), 5.24 (IH, d, J=4.4Hz), 5.52 (IH, d, J=6.0Hz), 6.73 (IH, d, J=8.2Hz), 6.83 (2H, d, J=8.3Hz), 7.05 (IH, s) , 7.3-7.5 (5H, m) , 7.65 (2H, d, J=8.2Hz), 7.74 (2H, d, J=8.4Hz), 7.98 (2H, d, J=8.4Hz), 8.11 (IH, d, J=8.4Hz), 8.31 (IH, d, J=8.4Hz), 8.79 (IH, d, J=7.7Hz), 8.84 (IH, s) FAB-MASS : m/z = 1245 (M + +Na) Elemental Analysis Calcd. for C5 H 71 N 8 θ2iSNa*4H2θ : C 50.07, H 6.15, N 8.65 Found : C 50.26, H 6.44, N 6.67 Example 23 NMR (DMSO-dg, δ) : 0.91 '3K, ;, J=6. " 7Hz), 0.96 (3H, d, J=6.8Hz), 1.05 (.., d, J=5.6Hz), 1.2-1.5 (6H, ) , 1.6-2.1 (5H, m) , 2.1-2.7 (4H, m) , 3.0-3.5 (9H, m) , 3.6-4.5 (15H, m) , 4.6-5.6 (11H, m) , 6.73 (IH, d, J=8.2Hz), 6.8-6.9 (4H, m) , 6.95 (2H, d, J=8.6Hz), 7.02 (2H, d, J=9.2Hz,, 7.04 (IH, s), 7.2-7.5 (3H, rr, , 7.82 (2H, d, J=8.6Hz), 8.06 (IH, d, J=8Hz), 8.25 (IH, d, J=6.7Hz), 8.43 (IH, d, J=6.7Hz), 8.85 (IH, s) IR (KBr) : 3350, 1668, 1629, 1510 cm "1 FAB-MASS : m/z = 1345 (M+Na) Elemental Analysis Calcd. for C5 H7 g N- LQ θ22SNa*6H 2 0 : C 48.67, H 6.41, N 9.78 Found : C 48.80, H 6.46, N 9.82 Example 24 Major product IR (KBr) : 3350, 1668, 1631, 1047 cm "1 NMR (DMSO-dg, δ) : 0.96 (3H, d, J=6.7Hz), 1.08 (3K, d, J=5.7Hz), 1.2-1.6 (10H, m) , 1.6-2.4 (8H, m) , 2.5-2.7 (IH, ) , 3.18 (IH, m) , 3.21 (3H, s), 3.29 (2H, t, J=6.4Hz), 3.6-3.83 (2H, m) , 3.83- 4.6* (13H, ) , 4.7-5.4 (11H, m) , 5.51 (IH, d, J=5.9Hz), 6.73 (IH, d, J=8.2Hz), 6.83 (IH, d, J=8.2Hz), 6.85 (IH, s) , 7.04 (2H, d, J=8.4Hz), 7.06 (IH, s), 7.31 (IH, ε) , 7.2-7.5 (2K, m) , 7.67 (2H, d, J=8.4Hz), 7.71 (2H, d, J=8.4Hz), 7.96 (2H, d, J=8.4Hz), 8.06 (IH, d, J=8Hz) , 8.25 (IH, d, J=6.7Hz), 8.74 (IH, d, J=6.7Hz), 8.84 (IH, s) FAB-MASS : m/z = 1319 (M+Na) Elemental Analysis Calcd. for : C 49.99, H 6.26, N 8.18 Found : C 49.74, H 6.27, N 8.06 Minor product IR (KBr) : 3350, 1668, 1631 cm -1 NMR (DMS0-d 6 , δ) : 0.96 (3H, d, J=6.7Hz), 1.08 (3H, d, J=5.7Hz), 1.2-1.6 (6H, ) , 1.6-2.1 (7H, m) , 2.1-2.5 (3H, ) , 2.5-2.7 (IH, ) , 3.18 (IH, m) , 3.6-3.8 (2H, ) , 3.8-4.6 (13H, m) , 4.6-5.2 (12H, ), 5.26 (IH, d, J=4.6Hz), 5.53 (IH, d. J=5.8Hz), 5.6-6.0 (IH, ) , 6.73 (IH, d, J=8.2Hz), 6.83 (IH, d, J=8.3Hz), 6.85 (IH, s) , 7.04 (2H, d, J=8.5Hz) , 7.06 (IH, s) , 7.30 (IH, s), 7.2-7.5 (2H, m) , 7.68 (2H, d, J=8.5Hz), 7.72 (2H, d, J-9.5HZ) , 7.96 (2H, d, J=8.5Hz), 8.06 (IH, d, J=8Hz), 8.25 (IH, d, J=6.7Hz), 8.74 (IH, d, J=6.7Hz), 8.85 (IH, s) FAB-MASS : m/z = 1287 (M+Na) Elemental Analysis Calcd. for C5 H 7 3NgN£θ22S*7H2C : C 48.34, K 6.30, N 8.05 Found : C 48.19, H 6.19, N 7.99 Example 25 IR (KBr) : 3350, 2935, 2873, 1668, 1629, 1538, 1506, 1438, 1257, 1049 cm "1 NMR (DMSO-dg, δ) : 0.9-1.0 (6H, m* , 1.03 (3H, d, J=5.7Hz), 1.2-1.6 (4H, m) , 1.6-2.0 (5H, m) , 2.1- 2.4 (3H, m) , 2.5-2.6 (IH, ) , 3.1-3.2 (IH, m) , 3.6-*-..6 (15H, m) , 4.7-5.2 (10H, m) , 5.26 (IH, d J=4.5Hz), 5.55 (IH, d, J=5.9Hz), 6.7-6.9 (3H, m) , 7.0-7.6 (7H, m) , 7.85 (2H, d, J=8.6Hz), 7.9- 8.2 (4H, m* , 8.26 (IH, d, J=7.7Hz), 8.8-9.0 (2K, m) FAB-MASS : m/z = 1314.3 (M+Na) + Elemental Analysis Calcd. for C5gH7oN 9 C23NaS-7H 2 0 : C 47.42, H 5.97, N 8.89 Found : C 47.33, K 5.85, N 8.73 Example 26 To a solution of The Starting Compound (1 g) and succinimido 4- (4-octyloxyphenyl)piperazine-l-carboxylate (0.45 g) in N,N-dimethy1formamide (10 ml) was added 4- dimethylaminopyridine (0.141 g) , and stirred for 5 days at 50°C. The reaction mixture was pulverized with ethyl acetate. The precipitate was collected by filtration, and dried under reduced pressure. Tne powder was dissolved in water, and subjected to column chromatography on ion exchage resin .'DOWEX-50WX4) eluting with water. The fractions containing the object compound were combined, and subjected to column chromatography on ODS (YMC- gelODS-AM'5-50) eluting with 50 acetonitrile aσueous solution. The fractions containing the object compound were combined, and evaporated under reduced pressure to remove acetonitrile. The residue was lyophiiized to give crude The Object Compound (23; . The powder of crude The Object Compound (23) was purified by preparative HPLC utilizing a C ] _g u Bondapak resin (Waters Associates, Inc.) which was eluted with a solvent system comprised of (acetonitrile-pH 3 phosphate buffer = 40:60) at a flow rate of 80 ml/minute using a Shimadzu LC-8A pump. The column was monitored by a UV detector set at 240 urn. The fractions containing the object compound were combined, and evaporated under reduced pressure to remove acetonitrile. The residue was subjected to cclumn chromatography on ion exchange resin (DOWEX-5CWX4) eluting with water. Tne fractions containing the object compound were combined, and subjected to column chromatography on ODS (YMC-gel*ODS-AM*S-50) eluting with 50 : acetonitrile aσueous solution. The fractions containing the object compound were combined, and evaporated under reduced pressure to remove acetonitrile. The residue was lyophiiized to give The Object Compound (23) ( 60 mg) . IR (KBr) : 3347, 1629, 151 ' 1245 cm -1 NMR (DMSO-d 6 , δ) : 0.86 C t, J=6.7Hz), 0.9= (3H, d, J=6.8Hz), 1.06 (3H, J=5.9Hz), 1.2-l.i, (10H, m) , 1.55-1.92 (5:.,. ) , 2.0-2.65 (4H, m) , 2.8-3.05 (5H, ) , 3.2-4.47 (17H, ) , 4.6-5.6 (12H, ) , 6.6-7.0 (7H, m) , 7.03 (IH, s) , 7.2-7.5 (3H, ) , 7.9-8.3 (3H, ) , 8.84 (IH, s) FAB-MASS : m/z = 1297 (M÷÷Na) Elemental Analysis Calcd. for C5 H 79 N 10 θ22 Na*6K2θ*CH3C : C 4 " .22, H 6.65, N 1C.82 Found : C 47.58, K 7.05, N 10.65 Example 27 To a suspension of 1-hydroxybenzotriazole (0.53 g) and 2- f -cctyloxyphenoxy) acetic acid (1 g) in dichiormethane (30 ml) was added l-ethyl-3- (3 ' - dimethylaminopropyl) carbodiimide hydrochloride (WSCD-HCl) (0.866 g) , and stirred for 3 hours at ambient temperature. The reaction mixture was added to water. Tne organic layer was taken, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and tne filtrate was evaporated under reduced pressure to give I- [2- (4- octyloxyphenoxy) acetyl]benzotriazole 3-oxide (892 mg) . To a solution of The Starting Compound (1.79 g) and l-[2-(4- octyloxyphenoxy) acetyl]benzotriazole 3-oxide (892 mg) in N,N-dimethylformamide (18 ml) was added 4-(N,N- dimethylamino)pyridine (0.297 g) , and stirred for 12 hours at ambient temperature. The reaction mixture was pulverized with ethyl acetate. The precipitate waε collected by filtration, and dried under reduced pressure. The powder was added to water, and subjected to ion- exchange column chromatography on DOWEX-50WX4, and eluted with water. The fractions containing the object compound were combined, and subjected to column chromatograph on ODS (YMC-gelODS-AM-S-50) , and eluted with 50"- methanol aqueous solution. The fractions containing the object compound were combined, and evaporated under reduced pressure to remove methanol. The residue was lyophiiized to give The Object Compound (24) (1.75 g) . IR (KBr) : 3350, 1666, 1629, 1228 cm "1 NMR (DMSO-d 6 , δ) : 0.86 (3K, t, J=6.9Hz), 0.95 (3H, a, J=6.7Hz), 1.04 (3H, d, J=5.7Hz), 1.15-1.5 (10H, ) , 1.55-2.0 (5H, ) , 2.05-2.5 (4H, m) , 3.16 (IH, m) , 3.72 (2H, m; , 3.88 (3K, t, J= β .3Hz), 4.41 (2K, s) , 3.93-4.6 (UK, m) , 4.69-5.25 (10H, m) , 5.28 (IH, d, J=4.3Hz,, 5.57 (IH, d, J=5.7Hz), 6.73 (IH, d, J=8.2Hz) , 6.8-7.0 (5H, m) , 7.04 (IK, s) , " '.Og (IH, s), 7.3-7.4 (2H, m) , 7.92-8.17 (2H, m) , 8.29 (IH, d, J=7.5Hz), 6.84 (IH, s) FAB-MASS : m/z = 1243 (M + +Na ' ι Elemental Analysis Calcd. for C51K73Ngθ23SNa- H2θ : C 47.36, H 6.31, N 8.66 Found : C 47.22, H 6.44, N 8.37 The Object Compounds (28) to (31) were obtained according to a similar manner to that of Example 27. Example 8 IR (KBr) : 3350, 2933, 1664, 1628, 1446, 1205, 1045 cm "1 NMR (DMSO-d 6 , δ) : 0.8-1.1 (9H, m) , 1.2-2.0 (19K, m) , 2.1-2.3 (3H, m) , 3.6-3.6 (4H, m) , 3.9-4.4 (13H, m) , 4.6-5.0 (8H, ), 5.07 (IH, d, J=5.6Hz), 5.14 (IH, d, J=3.2Hz), 5.23 (IH, d, J=4.3Hz), 5.46 (IH, d, J=6.7Hz), 6.7-6.9 (3H, m) , 7.04 (IH, s) , 7.2-7.5 (6H, m) , 7.8-8.0 (3H, m) , 8.05 (IH, d, J=8.4Hz), 8.2-8.4 (2H, m) , 8.83 (IH, s) FAB-MASS : m/z = 1360 (M * +Naj Elemental Analysis Calcd. for C59H 8Q Ngθ23SNa*6H2θ : C 48.99, H 6.41, N 6.72 Found : C 48.92, H 6.37, N 8.64 Example 29 IR (KBr) : 3350, 2927, 1668, 1627, 1535, 1515, 1452, ■ 1440, 1286, 1045 cm "1 NKR (DMSO-d 6 , δ) : 0.83 (3H, t, J=6.7Hz), 0.95 (3H, d, J=6.7Hz), 1.07 (3H, d, J=5.9Hz), 1.2-1.4 (12H, m) , 1.6-2.0 (5H, m) , 2.1-2.4 (3H, m) , 2.6 (IH, m, , 2.82 (2H, t, J=7.4Kz), 3.1-3.2 (IH, m) , 3.6-4.5 (13H, ) , 4.7-5.2 (11H, m) , 5.4-5.6 (IH, m) , 6.72 (IH, d, J=8.2Hz), 6.82 (2H, d, J=8.1Hz) , 7.03 (IK, s), 7.2-7.4 (3K, rr.) , 7.47 (IH, d, J=8.5Hz), 7.69 (IK, d, J=8.5Hz), 8.1-8.2 (2H, rr,) , 8.23 (IH, d, J=8.4Kz), 8.62 (IH, d, FAB-MASS : m/z = 1251 (M + +Na) Elemental Analysis Calcd. for C52H 7 3N 10 θ2 _SNa*5H2θ : C 47.34, K 6.34, N 10.61 Found : C 47.30, K 6.45, N 10.45 Example 30 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.8Hz), 0.96 (3H, t, J=6.7Hz), 1.05 (3H, t, J=5.8Hz), 1.2-1.5 (10H, m) , 1.6-2.0 (5H, , 2.2-2.4 (3K, m) , 2.5- 2 . 6 (IH, m) , 3.1-3.2 (IH, m) , 3.7-4.5 (15H, m) , 4.7-5.0 (8H, ), 5.10 (IH, d, J=5.6Hz), 5.17 (IH, d, J=3.1Hz), 5.26 (IH, d, J=4.5Hz), 5.52 (IK, d, J=5.8Hz) 6.73 (IH, d, J=8.2Hz), 6.8-7.0 (3H, ) , 7.04 (IH, s) , 7.2-7.4 (3H, ) , 3.0-8.3 (3H, m) , 8.68 (IH, d, J=2.3Hz), 8.7-8.8 (IH, m) , 8.85 (IH, ) FAB-MASS : m/z = 1214 (M + +Na) Elemental Analysiε Calcd. for C49H7oN9θ22SNa*4H 2 0 : C 46.55, H 6.22, N 9.97 Found : C 46.29, H 6.18, N 9.71 Example 31 IR (Nujol) : 3342, 2210, 1668, 1623 cm "1 NMR (DMSO-dg, δ) : 0.88 (3H, t, J=6.7Hz), 0.97 (3H, d, J=6.7Hz), 1.08 (3H, d, J=6.7Hz), 1.20-1.60 (8H, m) , 1.60-2.00 (5H, m) , 2.05-2.50 (4H, m), 3.05-3.30 (IH, m) , 3.60-4.60 (15H, ) , 4.65-5.18 (10H, m) , 5.24 (IH, d, J=4.5Hz) , 5.58 (IK, d, J=6.0Hz), 6.68-7.1C (4K, m) , 7.15-7.65 (5K, m) , 7.80-8.30 (6H, m) , 8.84 (IK, s), 9.18 (IH, d, J=7.7Hz) FAB-MASS : m/z = 1273.5 (M + +Na) Example 32 To a solution of 6-heptyIoxy-2-naphthoic acid (0.358 g) and triethylamine (0.174 ml) in N,N-dimethyl ormamide (10 ml) waε added diphenylphosphoryl azide (0.4 ml), and stirred for an hour at ambient temperature. Then, the reaction mixture was stirred for an hour at 100°C. After cooling, to the reaction mixture was added The Starting Compound (1 g) and 4- (N,N-dimethylamino)pyridine (0.14.0 g) , and stirred for 10 hours at ambient temperature. The reaction mixture was pulverized with ethyl acetate. The precipitate was collected by filtration, and dried under reduced pressure. The powder was dissolved in water, and subjected to column chromatography on ion exchange resin (DOWEX-50WX4) eluting with water. The fractions containing the object compound were combined, and subjected to column chromatography en ODS (YMC- gelODS-AM-Ξ-50) eluting with 50'- acetonitrile aqueous solution. The fractions containing the object compound were combined, and eva; orated under reduced pressure to remove acetonitrile. The residue was lyophiiized to give The Object Cor^ound (29) (0.832 g) . IR (KBr 3350, 1664, 1629, 1546, 1240 c~ -1 NMR (DMSC-d 6 , δ) : 0.88 (3H, t, J=6.6Hz), J.97 '3H, d, J=6.7Hz), .08 (3K, d, J=5.9Hz), 1.2-1.5:, (8H, m) , 1.55-2.0 (5H, m) , 2.1-2.5 (4H, ) , 3.18 (IH, m), 3.6-3.8 (3H, ) , 3.9-4.5 (13H, m) , 4.7-4.95 (3H, ) , 5.0-5.3 (7H, ) , 5.59 (IH, d, J=5.8Hz), 6.52 (IH, d, J=8.1Hz), 6.73 (IH, d, J--8.2HZ), 6.83 (IH, d, J=8.2Hz), 6.90 (IH, s) , " 7. C- "7 .15 (3H, m) , 7.2C ilH, s) , " . 21-1 . 4 t 3H, r. ) , 7.6-7.7 (2K, ml, 7.6 ~ (IK, s , , " \ 95-3.2 ,2K, ) , 8.69 (IH, s), 8.85 (IK, s) FAB-MS : m/z = 1264 (M + -rNa) Elemental Analysis Calcd. for C5 K72Ngθ22SNa-5H2θ : C 4 " . 6, H 6.20, N 9.46 Founα : C 4 " . 5, H 6.42, N 9.34 The Ob ect Compound (33) was obtained according to a similar manner to that of Example 52. Example 33 IR (KBr) : 3350, 1666, 1629, 153 " , 1240 cm "1 NMR (DMSO-d δ , δ) : 0.87 (3H, t, J=6.7Hz), 0.97 (3K, d, J=6.7Hz), 1.09 (3H, d, J=5.8Hz), 1.2-1.55 (8H, m) , 1.55-2.0 (5K, m) , 2.07-2.6 (4H, m) , 3.18 (IH, m) , 3.6-3.85 (3K, m) , 3.9-4.5 (13H, m) , 4. " 7-4.98 (3H, m) , 5.0-5.3 (7K, ) , 5.57 (iκ, d, J=5.9Hz), 6.50 (IK, d, J=8.1Hz), 6.73 (IK, d, J=8.2H∑), 6.82 (IH, dd, J=8.2 and 1.7Hz), 6.87 (IK, S ) , 6.97 (2H, d, J=8.8Hz), 7.05 (IH, d, J=i.7Hz), 7.10 (IH, s), 7.23-7.43 (2H, m) , 7.36 (2H, d, J=8.8Hz), 7.50 (2H, d, J=8.8Hz), 7.52 (2H, d, J=8.8Hz), 8.0-8.15 (2H, m) , 8.65 (IH, s), 8.84 (IH, s) FAB-MASS : m/z = 1290 (M + +Na) Elemental Analysis Calcd. for C55K 7 4Ngθ22SNa*7H2θ : C 47.38, H 6.36, N 9.04 Found : C 47.67, H 6.53, N 9.03 Example 34 A solution of The Starting Compound (2.45 g) , 3- [4- (4-pentylphenyl) henyl]propiolic acid (0.90 g) , l-ethyl-3- (3'-dimethylaminopropyl) carbodiimide hydrochloride (WSCD- HCl.- (0.59 g) and triethylamine (0.43 ml) m N,N- dimethylformamide (50 ml) was stirred for 15 hours at ambient temperature. The reaction mixture was diluted with ethyl acetate, and the resultant precipitate was collected by filtration, and washed in turn with ethyl acetate and diisopropyl ether, and dried under reduced pressure. The powder was dissolved in water, and was subjected to column chromatography on ion exchange resin (DOWEX-50WX4 (Na form, 50 ml)) eluting with water. The fractions containing the object compound were combined, and subjected to reversed phase chromatography on ODS (YMC-gel*ODS-AM*S-50, 50 ml) eluting with (water : acetonitrile = 10:0 - 7:3, V/V). The fractions containing the object compound were combined, and evaporated under reduced pressure to remove acetonitrile. The reεidue was lyophiiized to give The Object Compound (31) (1.53 g) . IR (Nujol) : 3351, 2212, 1668, 1627 cm "1 NMR (DMSO-dg, δ) : 0.87 (3H, t, J=6.5Hz), 0.96 (3H, d, J=6.7Hz), 1.08 (3H, d, J=5.8Hz), 1.20-1.50 (4H, m) , 1.50-2.00 (5H, ) , 2.03-2.55 (4H, m) , 2.62 (2H, t, J=7.5Hz), 3.17 (IH, t, J=8.4Hz), 3.55-4.57 (15H, m) , 4.65-5.13 (9H, ) , 5.16 (IH, d, J=3.2Hz), 5.24 (IH, d, J=4.5Hz), 5.58 (IH, d, J=5.8Hz), 6.67-6.90 (3H, m) , 6.93-7.10 (2H, m) , 7.15-7.50 (4H, m) , 7.50-7.90 (6H, ) , 8.06 (IK, d, J=8.4Hz), 8.15 (IH, d, J=7.7Hz), 8.84 (IH, s), 9.19 (IH, d, J-7.1HZ) FAB-MASS : m/z = 1255 (M + +Na) Elemental Analysis Calcd. for C55HggNgθ2iSNa* H2θ : C 50.61, H 5.95, N 8.58 Found : C 50.47, H 6.00, N 8.54 Example 35 To a suspension of l-hydroxybenzotriazole (501 g) and 4- (4-heptylphenyl)benzoic acid (1 g) in dichloromethane (30 ml) was added l-ethyl-3-(3'- dimethylaminopropyl) carbodiimide hydrochloride (WSCD-HCl) (839 mg) , and stirred for 3 hours at ambient temperature. The reaction mixture was added to water. The organic layer was separated, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure tc give l-[4-(4- heptylphenyl) enzoyl]benzotriazole 3-oxide. Tc a solutio: cf The Starting Compound (2.49 g) and 1-.4- - heptylphenyl) benzoyl1benzotriazole 3-oxide in N,N- dimethylformamide (25 ml) was added 4-(N,N- dimethylamino) pyridine (381 mg) , and stirred for 12 hours at ambient temperature. The reaction mixture was pulverized with ethyl acetate. The precipitate was collected by filtration, and dried under reduced presεure. The reεidue waε diεsolved in water, and subjected to column chromatography on ion exchange resin (DOWEX-50WX4) eluting with water. The fraction containing the object compound were combined, and subjected to column chromatography on ODS (YMC-gel*ODS-AM-S-5C) eluting with 30 " . acetonitrile aqueous solution. The fractions containing the object compound were combined, and evaporated under reduced pressure to remove acetonitrile. The residue was lyophiiized to give The Object Compound (32) (1.99 g) . IR (Nujol) : 3350, 2852, 1749, 1621, 1457, 1376, 1045 cm -1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=ό.7Hz), 0.96 (3H, d, J=6.7Hz), 1.08 (3H, d, J=5.9Hz), 1.5-1.7 (2H, m) , 1.7-2.2 (3H, m) , 2.2-2.5 (3H, m) , 2.6-2.8 (3H, ) , 3.1-3.2 (IH, m) , 3.7-4.6 (13H, m) , 4.7-5.2 (8H, ) , 5.12 (IH, d, J=5.5Hz), 5.16 (IH, d, J=2.9Hz), 5.27 (IH, d, J=4.4Hz), 5.54 (IK, d, J=5.8Hz), 6.7-6.9 (3H, ) , 7.05 (IK, s) , 7.2-7.4 (5H, m) , 7.65 (2H, d, J=8.0Hz), 7.74 (2H, d, J=8.3Hz), 7.98 (2H, d, J=8.3Hz), 8.11 2 C ^ - (IH, d, J=8.7K 8.28 (IH, d, J=9.4Hz , 8.76 (IH, d, J=7.3Hz, , 8.65 (IH, s) FAB-MASS : m/z = 1259 (M +J -Na) Elemental Analysiε Calcd. for C55H73N θ2iSNa-5H 2 0 : C 49.77, K 6.30, N 8.44 Found : C 49.98, H 6.44, N 8.41 The Object Compounds (36) to (107) were obtained according to a similar manner to that of Example 1. Example 36 IR (KBr) : 3350, 1675.8, 1629.6, 1515.6 cm "1 NMR (DMSO-dg, δ) : 0.86 (6K, d, J=6.6Hz), 0.96 (3H, d, J=6.6Hz) , -1.06 (3K, d, J=5.7Kz), 1.1- 3 (2H, ) , 1.4-2.0 (6H, m), 2.0-2.7 (4H, ) , 3.1-.,.5 (9H, m) , 3.66 (2H, t, J=7.3Hz), 3.6-4.5 (13K, ) , 4.7-5.6 (12K, in), 6.73 (IH, d, J=8.3Hz), 6.82 (IH, d, J=8.3Hz), 6.8-6.9 (IK, ) , 7.02 (2K, d, J=9.0Hz), 7.04 (IH, ε), 7.11 (2K, d, J=9.0Hz), 7.2-7.6 (3H, m) , 7.50 (2H, d, J=9.0Hz), 7.82 (2H, d, J=9.0Hz), 8.1 (IH, d, J=8.5Hz), 8.28 (IH, d, J=8.5Hz), 8.33 (IH, s), 8.45 (IH, d, J=7.0Hz), 8.84 (IH, s) FAB-MASS : m/z = 1412 (M+Na) Elemental Analysis Calcd. for C 60 H oNi3C > 22 SNa " 9H 2 0 : C 46.42, H 6.36, N 11.73 Found : C 46.64, H 6.43, N 11.62 Example 37 IR (KBr) : 3350, 1668.1, 1629.6, 1268.9 cm "1 NMR (DMSO-dg, δ) : 0.85 (3H, t, J=6.6Hz), 0.96 (3H, d, J=6.7Hz), 1.07 (3H, d, J=5.9Hz), 1.2-1.4 (10H, ) , 1.4-2.0 (5H, ), 2.0-2.5 (4H, ) , 2.61 (2H, t, J=7.2Hz), 3.1-3.3 (IH, ) , 3.6-4.5 (13K, ) , 4.40 (2H, s), 4.6-5.3 (11H, ) , 5.60 (IH, d, J=5.8Hz), 6.73 (IH, d, J=8.2Hz), 6.82 (IH, d, J=8.2Hz), 6.6- 6.9 (IH, m) , 7.04 (IH, s) , 7.C-7.1 (IH, , , " .32 (2K, d, J=6.5Hz) , 7.2-7.5 (2H, m, , " .Ec V '2H, d, J=8.5Kz) , 7.93 (IH, d, 6.04 (IH, a, J=9.4Hz) , 8.41 (IH, s) , 8.44 (IH, d, J=9.4Hz) , 8.84 (IH, s) FAB-MASS : m/z = 1294 (M+Na) Elemental Analysis Calcd. for C 3H7 N1 -. C22SNa*7H-0 : C 45.52, H 6.34, K 11.02 Found : C 45.4", K 6.27, N 10.93 Example 38 Major product IR (KBr) : 3349.7, 1670.1, 1627.6, 1508.1 cm "1 NMR (DMSO-dg, δ) : 0.96 (3H, d, J=6.6Hz), 1.06 (3H, d, J=5.7Hz), 1.2-1.6 (8H, m) , I.6-2. I (5K, m, , 2.1-2.7 (4H, m) , 3.0-3.2 (5H, m) , 3.21 (3K, ε) , 3.30 (2K, t, J=6.5Hz), 3.3-3.5 (4H, m) , 3.6-4.5 (15H, m; , 4.7-5.3 (11H, m) , 5.49 (IH, a, J=5.9Hz), 6.73 (IH, d, J=8.3Hz), 6.8-6.9 (4K, m) , 6.95 (2H, d, J=9.2Hz), 7.01 (2H, d, J=8.5Hz), 7.04 (IH, s), 7.20 (IH, s), 7.2-7.5 (2H, ) , 7.81 (2H, d, J=8.5Hz), 8.09 (IH, d, J=8.7Hz), 8.28 (IK, d, J=8.7Hz), 5.45 (IK, d, J=6.7Hz), 8.84 (IH, ε) FAB-MASS : m/z = 1389 (M+Na) Elemental Analysis Calcd. for C gK 3N-* Lθ θ23SNa*8H2C : C 47.68, H 6.60, N 9.27 Found : C 47.83, H 6.72, N 9.27 Minor product IR (KBr) : 3338.2, 1646.9, 1511.9 cm "1 NMR (DMSO-dg, δ) : 0.96 (3H, d, J=6.7Hz), 1.06 (3H, d, J=5.7Hz), 1.3-1.6 (4H, m) , 1.6-2.7 (11H, m) , 3.0- 3.2 (5H, m) , 3.3-3.5 (4K, m) , 3.6-4.5 (15H, m) , 4.7-5.3 (13H, ) , 5.48 (IH, d, J=5.9Hz), 5.7-6.0 (IH, ) , 6.73 (IH, d, J=8.2Hz), 6.6-6.9 (4H, m) , 6.94 (2H, d, J=9.3H∑) , 7.01 (2H, d, J=6.6Hz), ~.04 (IH, s , " .2-7.5 (3H, m) , 7.81 (2K, c, J=8.6Hz), 6.C (IK, ά, J=8.7Hz), 8.25 (IK, d, J=8.7Hz), 8.42 (IK, d, J=€.7Hz), 8.84 (IH, s) FAB-MASS : m/z = 1357 (M+Na) Elemental Analyεiε Calcd. for C - gEη : C 47.32, H 6.53, N 9.35 Found : C 47.08, H 6.66, N 9.25 Example 39 IR (KBr) : 3350, 1670.1, 1631.5, 1510.0, 1234.2 cm "1 NMR (DKSO-d , δ) : 0.87 (3H, t, J=6.7Hz), 0.96 (3K, o, J=6.7Hz), 1.06 (3H, d, J=5.6Hz), 1.2-1.5 (8K, m) , 1.6-2.1 (5H, m) , 2.1-2.7 (4H, ) , 3.0-3.3 (5H, m) , 3.3-3.5 (4H, m) , 3.6-3.8 (2H, m) , 3.88 (2H, d, J=6.4Hz), 3.8-4.5 (11H, m), .7-5.1 (8H, m) , 5.10 (IK, d, J=5.6Hz), 5.16 (IH, d, J=3.1Hz), 5.25 (IH, d, J=4.5Hz), 5.48 (IH, d, J=5.9Hz), 6.73 (IH, d, J=8.2Hz), 6.8-6.9 (4H, ) , 6.94 (2H, d, J=9.3Hz), 7.01 (2H, d, J=8.7Hz), 7.04 (IH, s) , 7.2-7.5 (3H, m) , 7.81 (2H, d, J=8.7Hz), 8.06 (IH, 1, J=8Hz), 8.25 (IH, d, J=6.7Hz), 8.43 (IH, d, J=6.7Hz), 8.85 (IH, s) FAB-MASS : m/z = 1359 (M+Na) Elemental Analysis Calcd. for C59H --_N Q O---.-jSNa-5H.--O : C 49.64, H 6.43, N 9.81 Found : C 49.49, H 6.54, N 9.72 Example 40 IR (KBr) : 3355.5, 1670.1, 1627.6, 1510.0 1236.1 cm "1 NMR (DMSO-dg, δ) : 0.89 (6H, d, J=6.5Hz), 0.96 (3H, d, J=6.7Hz), 1.05 (3H, d, J=5.7Hz), 1.2-1.4 (2H, m) , 1.5-2.1 (6H, m) , 2.1-2.7 (4H, ) , 3.0-3.6 (9H, m) , 3.6-4.5 (15H, ), 4.5-5.4 (12H, m) , 6.73 (IH, d, J=8.2Hz), 6.8-6.9 (4H, m) , 6.96 (2H, d, J=9.6Hz), 7.02 (2K, d, J=6.7Hz), 7.05 (IH, s. , 7.2-7.5 (3K, mj , 7.82 (2K, d, J=8.7Hz) , 8.06 'IK, ά, J=8Hz), 8.27 JIH, d, J=6.7Hz), 8.46 (IK, d, J= .7Hz), 8.85 (IK, s) FAB-MASS : m/z = 1345 (M+Na) Elemental Analysiε Calcd. for C5 H 7 gN Q θ22SNa*8K 9 θ : C 47.47, H 6.52, N 9.54 Found : C 47.47, H 6.54, N 9.51 Example 41 IR (KBr) : 3347.6, 1668.1, 1629.6, 1510.0, 1234.2 cm "1 NMR (DMS0-d 6 , δ) : 0.89 (3K, t, J=".0Hz), 0.96 (3K, d, J=6.7Hz), 1.05 (3H, d, J=5.8Hz), 1.2-1.5 (4H, ir.) , 1.6-2.1 (5K, m) , 2.1-2. " ' (4H, m) , 3.0-3.6 (9K, ) , 3.6-3.8 (2H, m) , 3.8-4.5 (13K, m) , 4.7-5.6 (12H, ic.) , 6.73 (IH, d, J=8.2Hz), 6.8-6.9 (4H, ) , 6.96 (2H, d, J=8.7Hz), 7.02 (2H, d, J=9.0Hz), 7.04 (IK, ε), 7.2-7.5 (3H, ) , 7.82 (2K, d, J=8.7Hz), 8.07 (IH, d, J=8Hz), 8.27 (IK, d, J=6.7Kz), 8.45 (IH, d, J=6.7Hz), 8.85 (IH, s) FAB-MASS : m/z = 1331 (M+Na) Elemental Analysis Calcd. for C5 7 H7-*N 10 θ22SNa*6H 9 O : C 48.30, H 6.33, N 9.88 Found : C 48.20, H 6.58, N10.03 Example 42 Mixture product IR (KBr) : 3344, 1670.1, 1631.5 c "1 NMR (DMSO-dg, δ) : 0.96 (3H, d, J=ό.7Hz), 1.06 (3K, d, J=5.9Hz), 1.2-1.5 (8H, m) , 1.6-2.1 (7H, ) , 2.1-2.7 (4H, m) , 3.1-3.3 (IH, m) , 3.6-4.5 (15H, m) , 4.45 and 4.70 (2H, t, J=7.1Hz), 4.6-5.3 (11H, m) , 5.52 (IH, d, J=5.9Hz), 6.73 (IH, d, J=8.2Hz), 6.83 (IK, d, J=8.2Hz), 6.85 (IK, s) , 7.03 (2K, d, J=8.6Hz), 7.05 (IH, s ) , 7.2-7.5 (3H, m) , 7.68 (2H, d. J=8.6Hz), 7.71 (2K, o, J=S.4Hz), 7.96 (2K, d, J=8.4Hz), 8.12 (IH, c, J=5.5Hz), 8.30 (IK, d, J=7.0Hz) FAB-MASS : m/z = 1357 (M÷Na) Elemental Analyεiε Calcd. for Z - ηEη : C 46.64, H 5.94, N 11.94 Found : Z 48.91, K 5.68, N 11.86 Example 43 IR (KBr) : 3350, 1666.2, 1651.5 cm "1 NMR (DMSO-dg, δ) : 0.96 , 3 , d, J=6.7Hz) , 1.C5 (6K, d, J=6.3Hz , 1.06 (3H, d, J=5.7Hz, , 1.2-1.6 (10H, ,- , 1.6-2.1 (7H, m) , 2.1-2.7 (6H, m, , 2.8-3.0 (2H, m) , 3.0-3.2 (IH, m) , 3.4-3.7 (2H, m) , 3.6-3.8 (2H, m) , 3.8-4.5 (13H, m) , 4.7-5.6 (12K, m) , 6.73 (IH, d, J=8.2Hz), 6.8-7.0 (2H, m) , 7.03 (2H, d, J=8.7Hz), 7.06 (IH, ε), 7.2-7.5 (3H, m) , 7.67 (2H, d, J=8.7Hz), 7.71 (2H, d, J=8.4Hz), 7.96 (2H, d, J=8.4Hz), 8.04 (IH, d, J=8.5Hz), 8.31 (IK, d, J=8.5Hz), 8.73 (IK, d, J=7.0Hz), 8.90 (IH, ε) FAB-MASS : m/z = 1402 (M+Na) Example 44 IR (KBr pelet) : 3350, 2929, 2856, 1670, 1631, 1510, 1243, 1045 cm "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.8Hz), 0.96 (3H, d, J=6.7Hz), 1.06 (3H, d, J=5.7Hz), 1.6-2.0 (5H, m) , 2.2-2.5 (5H, ) , 2.6-2.7 (IH, ) , 3.0-3.3 (5H, . 3.6-4.5 (19H, m) , 4.77 (2H, d, J=5.9Hz), 4.8-5.1 (6H, m) , 5.10 (IH, d, =5.6Hz), 5.17 (IH, d, J=3.1Hz), 5.25 (IH, d, J=4.5Hz), 5.50 (IH, d, J=5.8Hz), 6.7-7.0 (8K, m) , 7.04 (IH, ε), 7.2-7.4 (3H, m) , 8.0-8.2 (2H, ) , 8.26 (IH, d, J=8.0Hz), 8.55 (IH, d, J=7.3Hz), 8.67 (IK, d, J=1.2Hz), 8.85 (IH, s) FAB-MASS : m/z = 1374.3 (M+Na "1" ) Elemental Analysis Calcd. for Ct-. H 2Ni_3-~NaS-5.5H-0 : C 48.82, H 6.46, N 10.61 Found : C 48.89, K 6.74, N 10.50 Example 45 IR (KBr) : 3350, 2935, 1668, 1623, 1538, 1257, 1174, 1047 cm "1 NMR (DMSO-dg, δ) : 0.8-1.1 (6K, m) , 1.09 (3H, d, J=5.7Hz), 1.2-1.6 (6K, ; , 1.7-2.1 (5H, ) , 2.2-2.4 (3H, ) , 2.5-2.6 (IH, __' , 3.6-3.8 ,'2H, rαj , 3.6-4.6 (14H, ml, 4.8-5.2 (7K, ) , 5.18 (IH, d, J=3.1Hz), 5.26 (IH, d, J=4.5Hz), 5.54 (IH, d, J=5.8Hz), 6.7- 7.5 (9H, m) , 7.82 (IH, d, ,7=8.5Hz), 7.96 (IH, d, J=6.7Hz), 8.1-8.4 (5K, m) , 3.8-9.0 (2H, m) FAB-MASS : m/z = 1302.6 (M+Na x 1 Elemental Analysiε Calcd. for C 5 cH7 Q Ngθ23SNa*6H2θ : C 47.58, H 5.95, N 9.08 Found : C 47.46, H 6.04, N 9.05 Example 46 IR (KBr) : 3355, 2958, 1670, 1627, 1521, 1247, 1047 cm "1 NMR (DMS0-d 6 , δ) : 0.9-1.0 (6H, m) , 1.08 (3H, d, J=5.6Hz), 1.4-1.6 (2H, ) , 1.7-2.1 (5H, m) , 2.1-2.4 (3H, ) , 2.5-2.6 (IH, ) , 3.1-3.3 (IH, m) , 3.7-3.8 (2H, m) , 3.9-4.6 (13H, m) , 4.8-5.1 (8H, m) , 5.11 (IH, d, J=5.6Hz), 5.17 (IH, d, J=3.1Hz), 5.26 (IH, d, J=4.5Hz), 5.54 (IH, d, J=5.9Hz), 6.7-6.9 (3H, m) , 7.0-7.2 (3H, m) , 7.3-7.5 (3H, m) , 7.7-7.9 (8H, m), 8.02 (2H, d, J=8.4Hz), 8.08 (IH, d, J=8.4Hz), 8.32 (IH, d, J=7.7Hz), 8.81 (IH, d, J=7.0Hz), 8.85 (IK, s) FAB-MASS : n/z = 1309.3 (M+Na) + Elemental Analysis Calcd. for C5 H 7 N θ22 N aS-6H2θ : - ? ι 4 9 . 92 , H c . C C , N 3 . C 3 _ g o - τ- τ = c, • N 03 Example 47 IR (KBr) : 3350, 2933, 1666, 1629, 151 " , 1249, 1045 cm "1 NMR (DMSO-dg, δ) : 0.88 (3K, t, J=6.7Hz;, 0.96 (3K, d, J=6.7Hz), 1.08 (3H, d, J=5.8K∑), 1.7-2.7 (8K, m) , 2.1-3.3 (IH, m) , 3.6-4.5 (16H, ) , 4.7-5.2 (8H, ) , 5.16 (IH, d, J=3.1Hz:, 5.27 (IK, d, J=4.5Hz), 5.56 (IH, d, J=5.8Hz), 6.7-7.0 (3K, m) , " .0-7.2 (3K, IT., , ' .2-7.5 (5K, , , 8.0-S.4 (6K, r.) , δ.85 'IK, ε' , 8.96 (IH, d, J=7.0Hz), 9.C "7 (IK, s) FAB-MASS : m/z = 1276.6 (M+Na τ . Elemental Analysis Calcd. for : C 48.25, H 6.15, N 9.38 Found : C 48.10, H 6.14, N 9.30 Example 48 IR (KBr) : 3350, 2931, 1666, 1629, 1537, 1049 cm "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.9Hz), 0.9-1.5 (16H, ) , 1.6-2.4 (8H, m) , 2.5-2.7 (IH, m) , 3.1-3.3 (IH, m), 3.5-5.6 (25H, ) , 6.6-7.4 (8H, ) , 7.8-8.4 (6H, m) , 8.7-9.0 (2H, m) , 9.00 (IH, d, J=2.4Hz) FAB-MASS : m/z = 1331.4 (M+Na + ) Elemental Analysis Calcd. for C5gK73N 1 (-) ( *--'23 NaS ' 8K 2 c : C 46.28, H 6.17, N 9.64 Found : C 46.50.. K 6.27, N 9.65 Example 49 IR (KBr pelet) : 3300, 2931, 1668, 1650, 1629, 1538, 1515, 1268, 1049 cm -1 NMR (DMSO-dg, δ) : 0.87 (3H, t, J=6.6Hz), 0.97 (3H, d, J=6.7Hz), l . ' l (3H, d, 1.2-1.4 (6H, m) , 1.5-1.7 (2H, ..,), 1.7-2.1 (3K, m) , 2.1-2.4 (3H, m) , 2.6-2.7 (3H, m) , 3.1-3.2 (IK, m) , 3.7-3.9 (2H, m) , 3.9-4.5 (12H, m) , 4.8-5.1 (7H, m) , 5.11 (IK, d, J=5.5Hz), 5.18 (IH, d, J=3.1Hz), 5.27 fiH, d, J=4.5Hz) , 5.55 (IK, d, J=5.8Hz; , 6.7-7.0 (3K, ) , 7.06 (IK, ε), 7.3- " . (5K, ) , 7.72 (2H, d, J=3.2Hz) , 7.9-8.2 (5H, m) , 8.3-8.4 (4H, m) , 6.9-9.0 (2H, m) FAB-MASS : m/z = 1260.5 (M+Na τ > Elemental Analysis Calcd. for Cg_K 74 N g θ22 s a*6H2θ : C 50.58, K 5.98, N 8.70 Found : C 50.34, H 6.16, N 8.55 Example 50 IR (KBr) : 3369, 2956, 2935, 1670, 1629, 1525, 1473, 1247, 1047 cm "1 NMR (DMSO-dg, δ) : 0.95 (3H, t, J=7.3Hz), 0.97 (3K, d, J=6.7Hz), 1.09 (3H, d, J=5.7Hz), 1.3-1.6 (2K, m) , 1.7-2.1 (5H, m) , 2.1-2.4 (3H, m) , 2.5-2.6 (IH, m) , 3.1-3.3 (IH, m) , 3.7-4.6 (15H, m) , 4.7-5.1 (8H, m) , 5.10 (IH, d, J=5.6Hz), 5.18 (IH, d, J=3.1Hz), 5.26 (IK, d, J=4.4Hz), 5.56 (IH, d, J=5.7Hz), 6.7-7.0 (3H, m) , 7.1-7.2 (3K, m) , 7.2-7.4 (3H, ) , 7.70 (2H, d, J=8.6Hz), 7.78 (2H, d, J=8.4Hz), 8.1-8.4 (6H, m) , 8.85 (IH, s), 8.99 (IH, d, J=7.0H∑), 9.13 (IH, d, J=1.6Hz) FAB-MASS : m/z = 1310.1 (M+Na) ÷ Elemental Analysis Calcd. for C57H7 0 Ngθ22 N *-S" 7 H2θ : C 47.20, H 6.12, N 3.69 Found : C 47.42, H 6.19, N 8.92 Example 51 IR (KBr) : 3351, 2937, 2875, 1670, 1627, 1533, 1245, 1047 cm "1 NMR (DMSO-dg, δ) : 0.96 (3H, d, J=6.7Hz), 1.08 (3H, d, J=5.7Hz), 1.5-1.7 (2K, ) , 1.7-2.1 (7H, m) , 2.1- 2.4 (3H, ) , 2.5-2.6 (IH, ) , 3.1-3.2 (IH, m) , 3.7- 3.8 (2H, m) , 3.9-4.6 (15K, , , 4.7-4.9 (3K, m, , 5.0-5.1 (5H, m) , 5.10 (IK, d, J=5.6Hz), 5.17 ;ικ, d, J=3.1Hz), 5.26 (IH, d, J=4.5Kz), 5.52 (IH, d, J=5.9Hz), 6.7-7.1 (9H, m) , 7.2-7.5 (5H, m) , 7.68 (2H, d, J=8.2Hz), 7. 2 (2K, d, J=6.7Hz), 7.96 (2K, d, J=8.2Hz), 8.06 (IK, d, J=6.4Kz), 8.26 (IK, d, J= 7 .7Hz), 6.76 (IH, α, J=7.0Hz 8.65 (IK, ε) FAB-MASS : m/z = 1339.5 (M+Na * ; Elemental Analyεiε Calcd. for C5 H 7 3Ngθ23NaS*7H-0 : C 49.09, H 6.08, N 7.76 Found : C 49.04, H 6.08, N 7.82 Example 52 IR (KBr) : 3350, 2954, 2937, 1670, 1631, 1440, 1257, 1047 cm "1 NMR (DMSO-dg, δ) : 0.89 (3H, t, J=6.8Hz), 0.97 (3H, d, J=6.7Hz), 1.09 (2H, d, J=5.8Hz), 1.2-1.5 (6H, m) , 1.7-2.1 (5H, ) , 2.1-2.4 (3H, m) , 2.5-2.6 (IH, m) , 3.1-3.2 (IK, ) , 3.7-4.6 (15H, m) , 4.7-5.3 (11H, m) , 5.5-5.6 (IH, m) , 6.7-6.9 (IH, ) , 7.0-7.5 (6K, ) , 8.0-8.4 (8H, m) , 8.85 (IH, ε), 8.96 (IH, d, J=7.0Hz) APCI-MASS : m/z = 1329.0 (M+Na) ÷ Elemental Analysis Calcd. for C5 H7-.N 1 g0 7 3NaS*6H 2 0 : C 47.52, H 5.91, N 9.90 Found : C 47.42, H 6.05, N 9.90 Example 53 IR (KBr) : 3350, 2952, 1666, 1629, 1537, 1519, 1255 cm "1 NMR (DMSO-d 6 , δ) : 0.89 (3H, t, J=6.7Hz), 0.96 (3H, d, J=6.4Hz), 1.08 (3H, d, J=5.6Hz), 1.7-2.4 (8H, m) , 2.5-2.6 (IH, m) , 3.7-4.5 (15H, m) , 4.7-5.1 (8H, m) , 5.11 (IH, d, J=5.5Hz), 5.17 (IH, d, J=3.1Hz), 5.26 (IH, d, J=3.1Hz), 5.56 (IH, d, J=5.7Hz), 6.73 (IH, - j. _ c - a, J=£.2H_ , 6.7- " .C (2K, ir.) , 7.C5 (IH, s , .13 ,2K, , " = 6.7Hz* , 7.2- 7 .5 (3K, m , 7.9- l 2H, c, 3=6. "Hz , .l-δ.4 (6ή ' , itij , 8.85 (IK, s) , 8.92 (IK, d, J= " \OHz FAB-MASS : rr/z = 1345.3 (M+Na) * Elemental Ana_yειs Calcd. fcr Cπ,£K7-ι Nιρθ223'. a * SH ? C : C 45.84, H 5.96, N 9.55 Found : 3 45. e -7 , K 6.07, N 9.55 Example D4 IR (KBr pelet 1 : 3350, 2931, 1670, 1652, 1626, 1442, 1247, 1047 err "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.6Hz), 0.9 "7 (3H, d, J=ό.8Hz), 1.12 (3H, d, J=6.8Hz*, 1.2-1.5 (10H, m) , 1. 7 -2.0 (5H, m) , 2.2-2.4 (3K, m) , 2.5-2.6 (IH, m) , 3.1-3.2 (IH, m) , 3.72 (2H, br) , 3.8-4.5 '17H, m) , 4.7-5.2 (9H, m) , 5.26 (IH, d, J=4.6Hz), 5.57 (IH, d, J=5.7Hz), 6.7-7.1 (7H, ) , 7.3-7.5 (3H, mj , 7.66 (2H, d, J=8.7Hz), 8.10 (IH, d, J=7.6Hz), 8.17 (IH, d, J=7.6Hz), 8.76 (IH, d, J=7.0Hz), 8.85 (IH, s) FAB-MASS : m/z = 1293 (M+Na * ) Elemental Analysis Calcd. for C54H75N-. oθ22 N *- s ' 7 H,0 : C 46.41, K 6.42, N 10.02 Found : C 46.51, H 6.43, N 9.95 Example 55 IP (KBr) : 3345, 2937, 1650, 1511, 1249, 1047 cm "1 NMR (DMSO-dg, δ) : 0.91 (3H, t, =7.0Hz), 0.96 (3K, t, J=7.8Hz), 1.09 (3H, d, J= .8Hz), 1.3-1.5 (4H, ) , 1.6-2.1 (5H, m) , 2.1-2.5 (3H, m) , 2.5-2.6 (IH, m, , 3.1-3.3 (IK, ) , 3.7-3.9 (2K, ) , 3.9-4.6 (13H, ) , 4.79 (2H, d, J=5.9Hz), 4.8-4.9 (IH, ) , 4.9-5.2 (5H, m) , 5.10 (IH, d, J=5.9Hz), 5.17 (IH, d, J=3.1Hz), 5.25 (IH, d, J=4.6Hz), 5.53 (IH, d, J=5.9Hz), 6.7-7.0 (3K, mi, 7.0-7.2 (3H, m) , 7.19 (IH, sj, 7.3-7.5 (3K, ) , 7.7-8.1 (6K, ) , 8.08 (IH, d, J=10.0Hz), 8.26 (IK, d, J=8.8Hz), 8.77 (IH, m) , 8.85 (IH, ε . 13.32 (IH, ε) FAB-MASS : m/z = 13.-..0 (M-*-Na) + Eleme-.tal Analysis Calcd. for C 5 K 71 N 10 θ22SNa*8H2θ : C 46.86, H 6.11, N 9.76 Found : C 46.93, H 5.87, N 9.74 Example 56 IR (KBr) : 3350, 2956, 2935, 2872, 1666, 1629, 1247, 1045 cm "1 NMR (DMSO-dg, δ) : 0.9-1.1 (6H, m) , I. OS (3H, d, 0=6.0Hz), 1.4-1.6 (2H, m) , 1.6-2.1 (5K, m) , 2.1-2.4 (3H, ) , 2.5-2.6 (IH, m) , 3.1-3.3 (IH, m) , 3.6-4.5 (15H, m) , 4.7-5.1 (8H, m) , 5.10 (IH, d, J=5.5Hz), 5.17 (IH, d, J=2.9Hz), 5.25 (IH, d, J=4.5Hz), 5.55 (IH, d, J=5.7Hz), 6.7-6.9 (3H, ) , 7.0-7.5 (8K, m) , 7.68 (2H, d, J=8.9Hz), 7.73 (2H, d, J=8.3Hz), 8.01 (2H, d, --- .3HZ), 8.10 (IH, d, J=8.4Hz), 8.2? (IH, d, J=7.7H. , 8.8-9.0 (2H, m) FAB-MASS : m/z = 1299.5 (M+Na) + Elemental Analysis Calcd. for C 5 H N 8 0 2 3NaS*6H 2 0 : C 48.55, H 5.89, N 5.09 Found : C 48.52, H 5.94, N 8.07 Example 57 IR (KBr) : 3355.5, 1662.3, 1629.6, 1267.0 cm "1 NMR (DMSO-dg, δ) : 0.88 (3K, t, J=6.8H∑), 0.93 (3K, d, J=8.4Hz), 0.97 (3H, d, J 5.7Hz), 1.2-1.5 (4H, ) , 1.5-1.95 (5H, m) , 2.1-2.45 (4H, m) , 2.5-2.7 (4H, ), 3.17 (IH, m), 3.55-4.45 (14H, ) , 4.6-5.3 (13H, ) , 5.56 (IH, d, J=5.6Hz), 6.72 (IH, d, J=8.1Hz), 6.75 (IH, s), 6.77 (IH, d, J=8.1Hz), 7.04 (IH, s) , 7.10 (IH, s), 7.2-7.45 (10H, m) , 7.53 (4H, d. J=ό.6Hz), 7.85 (IH, d, J=7Hz) , 7.92 (IK, d, J-=7Hz , , 8.05 (IK, d, J=7Hz), 8.22 (IK, d, J=7Hz , 6.64 (IH, s) FAB-MASS : m/z = 1408 (M+Na) Example 58 IR (KBr) : 3347.8, 1664.5, 1631.5, 1245.8 cm "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.6Hz), 0.96 (3H, d, J=6.6Hz), 1.04 (3K, d, J=5.7Kz), 1.15-2.6 (21H, m) , 3.16 (IH, m) , 2.5-4.5 (16K, m) , 4.6-5.4 (13H, m; , 5.47 (IH, d, J=5.7Hz), 6.73 QK, d, J=8.2Hz 1 6.78-6.85 (4H, m) , ".05 (IK, s,, 7.10 (IH, s) , ~ . i (2H, d, J=8.6Hz), 7.25-7.45 (6H, m) , 7. 7 2 (IK, c, J=7Hz), 7.91 (IH, d, J=7Hz<, 6.05 (IH, d, J=9.3Hz), 8.20 (IH, d, J=7Hz), 8.85 (IK, s) FAB-MASS : m/z = 1390 (M+Na) Elemental Analysis Calcd. fcr C H *->N θ2_ιSNa*5H2θ : C 49.41, K 6.36, N 6.64 Found : C 49.77, K 6.71, N 8.71 Example 59 IR (KBr) : 3353.6, 1670.1, 1627.6, 1247.7 cm "1 NMR (DMSO-d 6 , δ) : 0.86 (3H, t, J=6.5Hz), 0.97 (3K, d, J=6.8Hz), 1.01 (3H, d, J=5.4Hz), 1.1-1.55 (12H, m) , 1.55-1.95 (5H, m) , 2.05-4.7 (4K, ) , 3.16 (IK, ) , 3.5-4.5 (16H, m) , 4.6-5.3 (13H, ) , 5.55 (IH, d, J=5.6Hz), 6.7-6.9 (5K, m) , 7.05 (IK, s) , 7.1 (IH, s), 7.15 (IH, d, J=8.5Hz), 7.25-7.5 (6H, rc) , 7.73 (IH, d, J=8.4Hz), 7.92 (IH, d, J=7Hz), 8.08 (IH, d, J=8.4Hz), 8.18 (IH, d, J=7Hz), 8.84 (IH, s) FAB-MASS : m/z = 1390 (M+Na) Example 6Q NMR (DMSO-d 6 , δ) : 0.85 (3H, t, J=6.6Hz), 0.96 (3H, d, J=6.6Hz), 1.05 (3H, d, J=5.6Hz), 1.1-1.5 (22H, m) , 1.5-2.5 (9H, m) , 2.5-3.5 (4H, A , 3.5-4.45 (14K, ) , 4.45-5.45 (12H, ) , 6.72 (IH, d, J=8.2Hz , 6.7 (IH, s ) , 6.81 (IH, d, J=6.2Hz), 7.04 (IH, s), 7.05- 7.5 (8H, m) , 7.9-8.3 (3H, m) , 8.84 (IK, ε) FAB-MASS : m/z = 1325 (M+Na) Elemental Analysis Calcd. for C5gH N θ2 ? SNa*6H-->0 : 3 49.35, H 7.14, N 7.94 Found : C 49.33, K 7.04, N 7.87 Example 61 IR (KBr) : 340C, 1668.1, 1629.6, 1270.9 cm "1 NMR (DMSO-dg, δ) : 0.96 (3H, d, J=6.8Hz), I.0c (3K, d, =5.7Hz), 1.1-2.0 (33H, m) , 2.1-2.5 (4H, m) , 3.2C (3H, s), 3.28 (2H, t, J=6.5Hz), 3.1-3.3 (IH, ) , 3.6-4.45 (14H, m) , 4.6-5.3 (13K, m) , 5.49 (IH, d, J=6.1Hz), 6.70 (IH, s) , 6.72 (IH, d, J=8.2Hz), 6.80 (IH, d, J=8.2Hz), 7.03 (IH, s), 7.0-7.1 (IH, m) , 7.15 (IH, s), 7.2-7.45 (6H, m) , 8.0-8.3 (3H, ) , 8.83 (IK, s) FAB-MASS : m/z = 1426 (M+Na) Elemental Analysis Calcd. for C 9 H 4 N 0 74 SNa*5H2θ : C 49.82, H 7.01, N 8.43 Found : C 49.86, H 7.31, N 8.40 Example 62 IR (KBr) : 3355.5, 1668.1, 1629.6, 1274.7 cm "1 NMR (DMSO-dg, δ) : 0.85 (3H, t, J=6.5Hz), 0.96 (3E, d, J=6.7Hz), 1.04 (3H, d, J=5.9 , 1.1-2.6 (34H, m) , 3.2 (IH, ), 3.6-4.55 (14H, r. . 4.7-5.3 (11H, .:■; , 5.47 (IH, d, J=5.9Hz), 6.72 (_ ' , d, J=8.IHz), 6.79 (IH, s), 6.81 (IH, d, J=8.1Hz), 7.05 (IH, s), 7.11 (IH, s), 7.2-7.5 (2H, ) , 8.0-8.15 (2H, m) , 8.21 (IH, d, J=8.0Hz), 8.84 (IH, s) FAB-MASS : m/z = 1235 (M+Na) Elemental Analysis Calcd. for C5*,Hg2Ngθ22S a*7H2C : C 5. 7 , 7 . 5, K 8.3 "" Found : C 45.55, K " \24, N 8.23 Example 63 I? (KBr 1 : 3353.6, 1664.5, 162 " .6 crr ~ - NKR (DKSO-dc, δ) : 0.66 ;3H, t, J=6.6Hz), 0.95 (3K, α, J=c.7Hz, , 1.04 (3H, , 3=5. Kz, , 1.2-2.7 ,3Cn, m, , 3.16 (IK, ) , 3.6-4.5 (13H, ) , 4. 7 -5.3 (UK, ir.) , 5.51 (IK, d, J=6.0Hz) , 5.7 (IK, s) , 6.72 (IK, d, .05 (IK, s) , 7.2-7.5 (3H, rr) , 6.0-6.3 (3H, in, , 3.85 1 IE, si FAΞ-MASS : m/z = 1204 (M-rNa) Elemental Analyεiε Calcd. for C*gH Ngθ2-ι SNa * 5H-->0 : C 47.24, K 6.90, N 8.81 Found : C 46.93, H 7.12, N 8.72 Example 64 .Major product IR (KBr) : 3400, 1675.8, 1631.5, 1511.9, 1234.2 cm "1 NMR (DMSO-dg, δ) : 0.96 (3H, d, J=6.6Hz), 1.05 (3K, d, J=5.8Hz) , 1.2-1.6 (10H, ) , 1.6-2.1 (5K, ) , 2.1- 2.7 (4H, m) , 3.05-3.2 (4H, m) , 3.20 (3K, s/, 3.29 (2K, t, J=6.4Hz) , 3.3-3.5 (5H, m) , 3.6-4.5 (15H, m) , 4.7-5.3 (11H, m) , 5.50 (IH, d, J=5.8Hz), 6.73 (IH, d, J=8.2Hz), 6.8-7.1 (9H, m) , 1.2-1 A (3K, m) , 7.81 (2H, d, J=8.6Hz), 8.08 (IH, a, J=8.2Hz), 8.24 (IK, d, J=7Hz), 8.44 (IK, d, J=7Hz), 8.84 (IH, ε^ FAB-MASS : m/z = 1403 (M+Na) Elemental Analysis Calcd. for Cg-,Hg 5 N-, Q θ 3SNa*9H 2 0 : C 47.47, H 6.73, N 9.07 Found : C 47.43, H 7.06, N 9.03 Minor product IR (KBr) : 3350, 1668.1, 1631.5, 1511.9, 1234.2 cm "1 - 22- - NMR (DMSO-dg, δ, : 0.96 (3K, d, J=6.6Hz), 1.07 (3K, d, J=5.8Hz), 1.2-1.5 (6K, ) , 1.55-2.1 (7K, j , 2.1- 2.65 (4H, ) , 3.0-3.6 (9K, m) , 3.7-4.5 (15K, m) , 4.7-5.6 (14H, m) , 5.7-6.C (IH, m) , 6.72 (IK, d, J=8.0Hz), 6.75-7.1 (9H, m) , 7.25-7.5 (3K, m) , 7.81 (2H, d, J=8.3Hz), 8.08 (IK, d, J=3.2Hz), 8.25 (IH, d, J=7Hz), 8.45 (IH, d, 3=7Hz), 8.85 (IK, ε . FAB-MASS : m/z = 1371 (M+Na) Elemental Analysis Calcd. for Cg 0 H8iNιo 0 2? SNa ' 8H 2° : C 48.25, H 6.55, N 9.38 Found : C 48.10, H 6.81, N 9.40 Example 65 IR (KBr) : 3450, 1668.1, 1635.3 cm "1 NMR (DMSO-dg, δ) : 0.88 (3K, t, J=6.5Hz), 0.96 (3K, d, J=6.7Hz), 1.06 (3H, d, J=6Hz) , 1.2-1.5 (6H, m) , 1.6-2.1 (5H, m) , 2.1-2.7 (4H, m) , 3.1-3.4 (9H, m) , 3.6-4.5 (15H, m) , 4.7-5.3 (11H, m) , 5.49 (IH, d, J=5.8Hz), 6.73 (IH, d, J=8.2Hz), 6.8-7.0 (2H, m) , 6.83 (2H, d, J=9.0Hz), 6.94 (2H, d, J=9.0Hz), 7.04 (IH, s), 7.12 (IH, t, J=8.4Hz), 7.2-7.5 (3H, m) , 7.65-7.8 (2H, m) , 8.09 (IH, d, J=8.4Hz), 8.25 (IH, d, J=7Hz), 8.63 (IH, d, J=7Hz) , 8.84 (IH, s) FAB-MASS : m/z = 1363 (M+Na) Elemental Analysis Calcd. for C5gH7gFN20°22 SNa ' 5H 2° : C 48.67, H 6.20, N 9.79 Found : C 48.83, H 6.15, N 9.74 Example 66 IR (KBr) : 3400, 1668.1, 1635.3, 1510.0, 1240.0 cm "1 NMR (DMSO-dg, δ) : 0.88 (3H, t, J=6.6Hz), 1.2-1.5 (6H, m) , 1.5-2.05 (5:-. ) , 2.1-2.65 (4H, m) , 3.1-3.3 (9H, m) , 3.6-4.5 (15H, m) , 4.7-5.3 (11H, m) , 5.51 (IH, d, =5.8Hz), 6.73 (IH, d, J=8.2Hz), 6.8-6.9 (4H, ) , 6.94 (2H, d, J=9.2Hz), 7.04 (IH, s ) , 7.24 (IH, d, J=8.5Hz), 7.15-7.5 (3H, m) , 7.86 (IH, dd, J=8.6 and 2.1Hz), 8.02 (IK, d, J=2.1Hz), 8.04 (IK, d, J=8.4Hz), 8.23 (IH, d, J=7Hz), 6.70 (IK, d, J=7Hz), 8.84 (IH, s) FA3-MASS : m/z = 1379 (M+Na) Elemental Analyεiε Calcd. for C5gH7gClN 0 θ22S a-6H2θ : C 47.52, K 6.19, N 9.55 Found : C 47.78, K 6.23, N 9.55 Example 67 IF (KBr) : 3400, 1670 cm "1 NMR (DMSO-d 6 , δ; : 0.96 (3H, d, J=6.7Hz), 1.05 (3H, d, J=5.7Hz), 1.4-2.65 (17H, m) , 2.65-3.6 (8H, m) , 3.6- 4.5 (15H, m) , 4.6-5.3 (11H, m) , 5.44 (IH, d, J=6.0Hz), 6.73 (IH, d, J=3.2Hz), 6.81 (IH, s), 6.83 (IH, d, J=8.2Hz), 6.98 (2H, d, J=8.9Hz), 7.05 (IH, s), 7.2-7.5 (3H, m) , 7.80 (2H, d, J=8.9Hz), 8.05 (IH, d, J=8.4Hz), 8.26 (IH, d, J=7Hz) , 8.39 (IH, d, J=7Hz), 8.84 (IH, s) FAB-MASS : m/z = 1229 (M+Na) Elemental Analysis Calcd. for : C 48.14, H 6.53, N 10.80 Found : C 48.29, H 6.33, N 10.95 Example 68 IR (KBr) : 3400, 1652.7, 1635.3, 1511.9, 1241.9 cm "1 NMR (DMSO-dg, δ) : 0.88 (3H, t, J=6.6Hz), 0.97 (3H, d, J=6.7Hz), 1.09 (3H, d, J=5.7Hz), 1.2-1.5 (6H, m) , 1.6-2.0 (5H, ) , 2.1-2.6 (4H, ) , 3.0-3.3 (5K, ) , 3.6-4.6 (19K, m) , 4.7-5.3 (11H, ) , 5.53 (IH, d, J=5.6Hz), 6.73 (IH, d, J=8.2Hz), 6.75-7.0 (2H, m) , 6.83 (2H, d, J=9.2Hz), 6.95 (2H, d, J=9.2Hz), 7.05 (IH, s), 7.12 (IH, s), 7.25-7.5 (2H, m) , 7.42 (IH, d, J=9.5Hz), 7.84 (IH, d, J=9.5Hz), 7.9-8.1 (2H, ) , 8.71 (IH, d, J=7Hz) , 8.84 (IH, s) FAB-MASS : m/z = 1347 (M+Na) Elemental Analysis Calcd. for C5 H 77 N-, 2 θ22S a*7H2θ : C 46.34, H 6.32, N 11.58 Found : C 46.38, H 6.18, N 11.36 Example 69 NMR (DMSO-dg, δ) : 0.88 (3H, t, J=6.6Hz), 0.97 (3K, d, J=6.7Hz,, 1.03 (3K, d, J=5.8Hz), 1.2-1.5 (6H, m) , 1.6-2.05 (5H, ) , 2.1-2.6 (4H, ) , 3.0-3.3 (5K, m) , 3.4-3.55 (4K, ) , 3.7-4.6 (15H, ) , 4.7-5.3 (UK, m) , 5.52 (IH, d, J=5.8Hz), 6.73 (IH, d, J=8.1Kz), 6 . 8- 6 . 95 (2K, ) , 6.83 (2K, d, J=9.3Hz , 6.95 (2K, d, J=9.3Hz) 7.05 (IH, ε), 7.14 (IK, ε), 7.3-7.6 (3H, m) , 7.84 (IH, d, J=6.6Hz), 7.95-8.1 (2H, m) , 8.40 (IH, ε), 8.42 (IH, d, J=7Hz), 8.84 (IH, s) FAB-MASS : m/z = 1346 (M+Na) Elemental Analysis Calcd. for Cr-^^gN-, 2C>22 SN a"5H2 : C 48.40, H 6.27, N 10.89 τ ind : C 48.32, H 6.44, N 10.86 Example 70 IR (KBr) : 3400, 1668.1, 1623.6, 1511.9 cm "1 NMR (DMSO-dg, δ) : 0.96 (3H, d, J=6.7Hz), 1.06 (3H, d, J=5.7Hz), 1.15-1.5 (6H, m) , 1.6-2.0 (7H, m) , 2.1- 2.65 (5H, m) , 3.1-3.5 (9H, m) , 3.6-4.5 (13H, ) , 4.7-5.3 (11H, ) , 5.46 (IH, d, J=5.9Iz), 6.73 (IH, d, J=8.2Hz), 6.81 (IH, s), 6.84 (IH, d, J=8.2Hz), 6.91 (2H, d, J=8.7Hz), 6.95-7.05 C ' , mj , 7.09 (2K, d, J=8.7Hz), 7.25- * .5 (3K, m) , 7.81 (2H, d, J=8.8Hz), 8.09 (lh, d, J=7Hz) , 8.25 (IH, d, J=7Hz), 8.04 (IH, a, J=7Hz), 8.84 (IH, s) FAB-MASS : m/z = 1327 (M+Na) Elemental Analysis Calcd. for C 5 gH7 N ø°21 SNa ' 5H 2 0 : C 49.92, H 6.28, N 10.03 Found : C 49.75, H 6.41, N 10.25 Example 71 IR (KBr) : 3350, 1668.1, 1629.6, 1511.9, 1232.3 cm "1 NMP (DMSO-dg, δ) : 0.85 (3H, t, J=6.5Hz), 0.96 (3H, d, J=6.7Hz), 1.06 (3H, d, J=6.0Hz), 1.2-1.4 (6H, m) , 1.4-1.6 (2H, m) , 1.7-2.1 (3H, m) , 2.1-2.7 (OK, m ; , 3.1-3.5 (9H, m) , 3.7? (2H, m) , 3.8-4.5 (11H, ) , 4.7-5.3 (11H, m) , 5.4 * (IH, d, 3=5.9Hz) , 6.73 t in, a, J=8.2Hz), 6.8-6.9 (2H, mj , 6.91 (2K, d, J=8.6Hz), 6.95-7.15 (5H, m) , 7.25-7.5 (3K, ) , 7.81 (2K, d, J=8.8Hz), 8.09 (IH, d, J=8.4Hz), 8.26 (IK, d, J=7Hz), 8.40 (IH, d, 3=7Hz) , 8.64 (IK, si FAB-MASS : m/z = 1329 (M+Na) Elemental Analysis Calcd. for C^gK^g -, 0 Naθ2 S-6K2θ : C 49.22, H 6.48, N 9.90 Found : C 49.33, H 6.67, N 9.89 Example 72 IR (KBr) : 3450, 1668.1, 1631.5, 1240.0 cm "1 NMR (DMSO-dg, δ) : 0.96 (3H, d, J=6.6Hz), 1.05 (3H, d, J=5.6Hz), 1.3-1.7 (4K, m) , 1.7-2.1 (7H, m) , 2.1- 2.73 (6K, m) , 2.75-3.05 (4H, m) , 3.05-4.5 (18H, m) , 4.7-5.5 (12H, ) , 6.72 (IH, d, J=8.3Hz), 6.77-6.9 (2H, m) , 6.96 (2H, d, J=8.6Hz), 7.05 (IK, s), 7.1- 7.5 (8H, m) , 7.80 (2H, d, J=8.6Kz), 8.06 (IH, d, J=8.4Hz), 8.28 (IH, d, J=7Hz), 8.41 (IH, d, J=7Hz) , 8.84 (IH, s) FAB-MASS : m/z = 1305 (M+Na) Elemental Analysis Calcd. for C5gH 7 gN2o 0 2i s ' 8K 2 0 : C 48.80, H 6.64, N 9.81 Found : C 48.88, H 6.50, N 9.81 Example 73 IR (KBr) : 1673.9, 1646.9, 1510.0 1238.1 cm "1 NMR (DMSO-dg, δ) : 0.87 (3H, t, J=6.4Hz), 0.96 (3H, d, J=6.6Hz), 1.05 (3H, d, J=5.6Hz), 1.2-1.5 (6H, ) , 1.5-2.C (9K, r , 2.1-2.8 (UK, m) , 3.1-3.4 (5K, rr.) , 3.4-4.5 (17H, rr.) , 4.6-5.5 (12K, TC. I , 6.6-7.0 (9H, m) , 7.04 (IK, s), 7.2-7.5 (3H, m) , 7 .7g (2 H, d, J=8.7Hz), 8.05 (IK, d, J=8.4Hz), 8.24 (IH, d, J=7Hz), 8.39 (IK, -., 3=7Hz), 8.64 (IH, ε) FAB-MASS : m/z = 132 M * -S0 3 +Na) Elemental Analyεiε Calcα. for Cg 3 Kg Nι_-, G ?7 S*9H 2 0 : C 48.92, H 6.97, N 9.96 Found : C 48.77, H 6.73, N 9.94 Examp e 74 IR (KBr) : 3450, 1670.1, 1631.5, 1280.5 cm "1 NMR (DMSO-dg, δ) : 0.87 (3H, t, = 7 . OHz), 0.96 (3H, t, J=6.8Hz), 1.05 (3H, d, J=5.6Hz), 1.1-1.65 (13H, m) , 1.65-2.1 (7K, m) , 2.1-2.65 (5K, m) , 3.17 (IK, ) , 3.6-4.5 (13H, m) , 4.7-5.3 (11H, m) , 5.49 (IH, d, J=5.9Hz), 6.72 (IH, d, J=8.2Hz), 6.82 (IH, d, J=8.2Hz), 6.84 (IH, s) , 7.04 (IH, s) , 7.29 (2H, d, J=8.3Hz), 7.2-7.5 (3H, ) , 7.80 (2H, d, J=8.3Hz), 8.10 (IH, d, J=8.4Hz), 8.26 (IH, d, J=7Hz), 8.65 (IK, d, J=7Hz), 8.84 (IH, s) FAB-MASS : m/z = 1237 (M+Na) Elemental Analysis Calcd. for C53H E-N θ22-~ a-6H2θ : C 48.10, H 6.63, N 8.47 Found : C 48.26, H 6.62, N 8.46 Example 7? IR (KBr) : 3400, 1670.1, 1627.6, 1272.8 cm "1 NMR (DMSO-dg, δ) , 0.96 (3K, d, J=3.3Hz), 1.08 (3H, d, J=5.7Hz), 1.2-1.6 (10H, ) , 1.6-2.1 (5K, m) , 2.1- 2.7 (4H, ) , 3.0-3.3 (IH, m) , 3.20 (3H, s), 3.29 (2H, t, J=6.4Hz), 3.73 (2H, m) , 3.9-4.6 (13H, m) , 4.7-5.3 (11H, ) , 5.53 (IH, d, J=5.8Hz), 6.73 (IH, d, J=8.3Hz), 6.83 (IH, d, J=8.3Hz), 6.91 (IH, s), 7.05 (IH, s), 7.23 (IH, dd, J=9.0 and 2.3Hz), 7.3- 7.5 (4H, m) , 7.8-8.0 (3H, ) , 8.CS (IK, α, 3=6.4Hz), 8.33 (IH, d, J=7Hz), 8.44 (IH, s , 8.83 (IH, d, 3=7Hz), 8.85 (IK, s) FAB-MASS : m/z = 1293 (M+Na) Elemental Analysis Calcd. for : C 47.89, K 6.36, N 8.12 Found : C 47.81, K 6.26, N 6.05 Example 76 IP (KBr) : 3361.3, 1668.1, 1635.2, 1627.6 cm "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, J=6.7Hz), 0.96 (3K, d, 3=6.7Hz), 1.09 (3H, d, 3=5.8Kz), 1.19-1.25 (8K, m, , 1.25-2.00 (5H, m) , 2.02-2.53 (4H, m) , 2.44 (3K, s, , 2.61 (2K, t, J=7.6Hz), 3.05-3.27 (IK, m) , 3.55-4.50 (13K, m) , 4.65-5.65 (12H, m) , 6.42 (IH, s), 6.65- 6.95 (3H, m) , 7.05 (IH, d, 3=0.4Hz), 7.13-7.50 (5H, ) , 7.50-7.88 (6H, m) , 8.10 (IH, d, J=9.0Hz), 8.25 (IH, d, J=8.4Hz), 8.40 (IH, d, J=7.0Hz), 8.85 (IH, s) FAB-MASS : m/z = 1299.3 (M+Na-1) Elemental Analysis Calcd. for C5gH 7 N Naθ2 S-5H2C : C 50.94, H 6.41, N 6.19 Found : C 50.99, K 6.40, N 8.15 Example 77 IR (Nujol) : 3351.7, 1670.1, 1652.7, 1623.8 cm "1 NMR (DMSO-dg, δ) : 0.86 (3K, t, J=6.7Hz), 0.96 (3H, d, J=6.7Hz), 1.06 (3H, d, J=5.8Hz), 1.13-1.45 (8H, m) , 1.47-1.96 (5H, ) , 2.06-2.66 (8H, si), 2.81 (2H, t, J=7.6Hz), 3.04-3.30 (IK, ) , 3.53-4.50 (13H, m) , 4.53-5.70 (12H, ) , 6.64-6.88 (3H, ) , 7.04 (IK, d, J=0.4Hz), 7.13-7.60 (11H, m) , 8.10 (IH, d, J=9.0Hz), 8.18 (IH, d, J=8.4Hz), 8.30 (IH, d, J=7.0Hz), 8.85 (IH, ε) FAB-MASS : m/z = 1287.4 (M+Na-1) Elemental Analysis Calcd. fcr : 3 50.51, H 6.46, N 8.2^ Founc : C 50.64, H 6.60, N 8.33 Exa ple 78 IR (KBr) : 3361.3, 1683.6, 1670.1, 1662.3, 1652.7, 1646.9, 1635.3, 162 7 .6, 1623.8 cm "1 NMR (DMSO-dg, δ) : 0.97 3H, d, 3=6.7Hz), l.G" (3H, d, 3=5.6Hz), 1.28-2.00 (13H, m) , 2.08-2.60 (4H, m) , 3.07-3.30 (IK, m) , 3.60-4.66 (17K, m) , 4.66-5.12 (9H, K) , 5.11 (IK, d, 3=3. IHz), 5.25 (IK, d, 3=4.6Hz), 5.52 (IH, d, 3=6.0Hz,, 6.62-6.95 (4H, rr,, 6.95-7.15 (3H, m) , 7.20-7.50 (3H, m) , 7.50-7.85 (7H, m) , 8.12 (IH, d, 3=8.4Hz), 8.35 (IH, d, 3=7.7Hz), 8.53 (IH, d, 3=7.0Hz), 8.85 (IH, s) FAB-MASS : m/z = 1319.7 (M+Na-1) Elemental Analysis Calcd. for C5 7 H 74 N Naθ22S -8H2θ : C 47.49, H 6.29, N 7.77 Found : C 47.79, H 6.16, N 7.93 Example 79 IR (KBr) : 3354.9, 1668.1, 1662.3, 1654.6, 1646.9, 1627.6 cm "1 NMF DMSO-dg, δ) : 0.85 (3H, t, J=6.7Hz), 0.90-1.10 (6H, ) , 1.10-1.40 (8H, m) , 1.48-1.95 (5H, m) , 2.05-2.46 (4H, m) , 2.60 (2K, t, J=7.6Hz), 3.C7-3.23 (IH, ) , 3.55-4.45 (14H, m) , 4.67-5.32 (11H, ) , 5.48-5.63 (IH, m) , 6.22 (IH, , J=5.3Hz), 6.65-6.89 (3H, m), 6.97-7.15 (2H, ) , 7.20-7.68 (10H, ) , 7.85-8.20 (3H, m) , 8.84 (IH, s) FAB-MASS : m/z = 1289.4 (M+Na-1) Elemental Analysis Calcd. for C5 H 7 5NgNaθ22S-3H 2 0 : C 50.90, H 6.18, N 8.48 Found : C 50.80, K 6.44, N 8.29 Example 80 IR (KBr) : 3361.3, 1664.3, 1631.5, 1600.6 cm "1 NMP (DMSO-dg, δ) : 0.86 (3H, t, 3=6.7Hz) , 0.98 (3K, d, 3=6.7Hz), 1.16 (3H, t, 3=5.9Hz), 1.20-1.45 (8K, m) , 1.50-1.70 (2H, m), 1.70-2.05 (2K, ) , 2.10-2.57 (4H, m) , 2.63 (2H, t, 3=7.6Ez : , 3.10-3.30 (IH, ) , 3.68-4.50 (13K, ) , 4.78-5.32 (UK, ) , 5.66 (IH, d, 3=5.7Hz), 6.68-7.02 (3H, m) , 7.04 (IH, α, 3=0.4Hz), 7.25-7.48 (4H, ) , 7.60-8.08 (7H, rr.) , 8.10 (IH, d, 8.28 (IH, c, 3=7.7Hz), 8.85 (IH, ε), 9.30 (IH, d, 3=7.1Hz) FAB-MASS : m/z - 1287.5 (M+Na-D Elemental Analyεiε Calcd. for C55H 7 3NgNaθ22 Ξ ' 3H 2° : C 50.53, H 6.09, N 3.37 Found : C 50.66, H 6.01, N 8.22 Example 81 IR (KBr) : 3349.7, 1668.1, 1627.6 cm "1 NMR (DMSO-dg, δ) : 0.85 (3H, t, 3=6.7Hz), 0.96 (3H, d, 3=6.7Hz), 1.09 (3H, d, J=5.8Hz), 1.18-1.48 (8H, m) , 1.50-2.10 (5H, m) , 2.10-2.45 (3H, m) , 2.50-2.65 (IH, m) , 2.77 (2H, t, 3=7.6Hz), 3.05-3.25 (IH, m; , 3.60-4.65 (13H, m) , 4.67-5.60 (12K, ) , 6.65-6.97 (3H, m) , 7.05 (IH, d, 3=0.4Hz), 7.21-7.43 (4K, m) , 7.76 (IH, s), 7.83-8.05 (3H, m) , 8.10 (IH, d, 3=9.0Hz), 8.29 (IH, d, 3=8.4Hz;, 8.48 (IH, s), 8.64-9.03 (2H, m) FAB-MASS : m/z = 1233.0 (M+Na-1) Elemental Analysis Calcd. for C53H 7 -,NgNaθ2o*3"3H2θ : C 50.96, H 6.22, N 8.96 Found : C 50.62, K 6.40, N 8.92 Example 92 IR (KBr) : 3361.3, 1670.1, 1627.6 cm "1 NMR (DMSO-dg, δ) : 0.88 (3H, t, 3=6.7Hz), 0.96 (3K, d, 3=6.7Hz), 1.09 (3H, d, 3=5.9Hz; , 1.16-1.43 (6H, mj , 1.50-2.10 (5H, ) , 2.10-2.69 (4K, m , 2. n l (2H, t, 3=7.6Hz), 3.07-3.29 (IH, m; , 3.60-4.62 (13H, ) , 4.69-5.23 (10H, m) , 5.27 (IH, d, 3=4.5Hz), 5.55 (IH, d, 3=5.9Hz), 6.68-7.00 (3H, m) , 7.05 (IH, d, 3=0.4Hz), 7.25-7.53 (4K, m, , 7.76 (IH, s), 7.84- 8.05 (3H, m) , 8.13 (IK, d, 3=6.4Hz , 8.33 (IK, d, 3=7.7Hz), 8.48 (IH, s), 8.73-9.00 (2H, m) FAB-MASS : m/z = 1219.4 (M+Na-1) Elemental Analysiε Calcd. for C5 9 H NgNaθ2 S-5H 0 : C 48.51, H 6.19, N 8.71 Found : C 48.67, H 6.3 , N 8.74 Example 83 IR (KBr) : 3357.5, 1668.1, 1627.6 cm "1 NMR (DMSO-dg, δ) : 0.97 (3H, d, 3=6.7Hz), 1.07 (3K, d, 3=6.0Hz), 1.20-1.62 (10H, ) , 1.62-2.00 (5H, m) , 2.10-2.65 (4H, m) , 3.20 (3H, s) , 3.08-3.45 (IH, m) , 3.28 (2H, t, J=6.5Hz), 3.53-4.50 (15H, m) , 4.68- 5.13 (9H, m) , 5.17 (IH, d, 3=3.1Hz), 5.25 (IH, d, 3=4.4Hz), 5.53 (IH, d, 3=6.0Hz), 6.68-6.95 (4H, m) , 6.95-7.11 (3H, ) , 7.20-7.52 (3H, m) , 7.55-7.95 (7H, -.) , 8.13 (IH, d, J=8.4Kz), 8.30 (IH, d, 3=7.7Hz), 8.52 (IH, d, 3=7.0Hz), 8.85 (IH, s) FAB-MASS : m/z = 1345.2 (M+Na-1) Elemental Analysis Calcd. for C 5 gH7gN 8 Naθ23S*8H 2 0 : C 48.29, H 6.53, N 7.64 Found : C 48.4" H 6.58, N 7.75 Example 84 IR (KBr) : 3353.6, 1662.3, 1627.6 cm "1 NMR (DMSO-d 6 , δ) : 0.96 (3H, d, 3=6.7Hz), 1.07 (3H, d, J=5.5Hz), 1.40-1.65 (2H, m) , 1.65-2.00 (5H, ) , 2.00-2.67 (6H, m) , 3.08-3.30 (IH, m) , 3.50-4.50 (15H, m) , 4.68-5.13 (11H, ) , 5.18 (IH, d, /11210 - 230 - 5.26 (IH, d, 3=4.5Hz), 5.53 (IK, d, J=c.0Hz , 5.70-6.00 (IH, ) , 6.63-6.95 (4H, ) , Jπ i m , 20-7 . ' 3H, ) ,2-7.95 (7H, mj, 6.12 (IH, d, 3=8.4Hz), 8.31 (IH, d, 3=7.7Hz, , 6.53 (IH, a, 3=7.0Hz), 6.85 (IH, s) FAB-MASS : m/z = 1285.4 (MτNa-1) Elemental Analysis Calcd. for : C 47.79, K 6.23, N 7.96 Found : C 4 7 .59, H 6.32, N 8.06 Exa le 85 IR (KBr) : 3363.2, 1670.1, 1627.6 cm "1 NMR (DMSO-d 6 , δ) : 0.89 (6K, d, 3=6.5Hz), 0.96 (3K, d, 3=6.7Hz), 1.07 (3K, d, 3=5.7H∑), 1.22-1.41 (2H, ) , 1.50-1.97 (6K, ) , 2.11-2.65 (4H, ) , 3.10-3.30 (IH, m) , 3.60-4.50 (15H, ) , 4.70-5.08 (8K, m) , 5.10 (IH, d, 3=5.6Hz), 5.16 (IH, d, 3=3.1Hz), 5.25 (IH, d, 3=4.5Hz), 5.50 (IH, d, 3=5.9Hz), 6.65-6.92 (4H, m) , 6.92-7.12 (3H, m) , 7.21-7.50 (3H, ) , 7.52-7.90 (7H, m) , 8.12 (IH, d, 3=6.4Hz), 8.30 (IH, d, 3=7.7Hz), 8.56 (IH, d, 3=7.0Hz), 8.85 (IK, s) FAB-MASS : m/z ~ 1287.6 (M+Na-1) Elemental Analysis Calcd. for C 5 H 7 3NgNaθ22S' 6 -5H 2 0 : C 48.66, H 6.27, N 8.11 Found : C 48.67, K 6.32, N 8.20 Example 86 IR (KBr) : 3361.3, 1683.6, 1670.1, 1654.6, 1635.3, 1623.8 cm "1 NMR (DMSO-dg, δ) : 0.97 (3H, d, 3=6.7Hz), 1.07 (3K, d, 3=5.6Hz), 1.30-2.00 (UK, vs.), 2.10-2.70 (4H, ) , 3.05-3.15 (IK, ), 3.55-4.70 (17H, ) , 4.70-5.11 (9H, m) , 5.16 (IH, d, J=3.1Hz), 5.25 (IH, d, J=4.5Hz), 5.52 (IH, d, J=6.0Hz), 6.65-6.95 (4H, m) , 6.95-7.10 (3H, m) , 7.10-7.50 (3H, m) , 7.50-7.85 ( " .-., m, , 8.12 (IK, d, 3=8.4Hz), 8.30 (IK, d, 3=8.3Hz), 8.52 (IH, o, 3=7.0Hz), 8.85 (IK, s) FAB-MASS : m/z = 1305.2 (M+Na-1) Elemental Analysiε Calcd. for C5 H 7 2 gNaθ22SF*6H2θ : C 46.34, H 6.09, N 8.05 Found : C 48.47, H 6.29, N 7.95 Example 87 IR (KBr) : 3359.4, 1668.1, 1654.6, 1625.7 cm "1 NMR (DMSO-dg, δ) : 0.97 (3h, d, 3=6.7Kz), 1.07 (3H, d, 3=6.0Hz), 1.22-1.62 (6K, m) , 1.62-2.00 (5K, m) , 2.10-2.65 (4H, m) , 3.20 (3H, s), 3.05-3.40 (IK, ) , 3.31 (2H, t, 3=6.5Hz), 3.60-4.55 (15H, m) , 4.65- 5.13 (9H, ) , 5.16 (IH, d, 3=3.1Hz), 5.26 (IH, d, 3=4.4Hz), 5.53 (IH, d, 3=6.0Hz), 6.68-6.95 (4H, rc) , 6.95-7.20 (3K, m) , 7.20-7.58 (3H, m) , 7.58-7.90 (7H, m) , 8.13 (IH, d, 3=8.4Hz), 8.32 (IH, d, 3=7.7Hz), 8.53 (IH, d, 3=7.0Hz), 8.85 (IH, s) FAB-MASS : m/z = 1317.6 (M+Na-1) Elemental Analysis Calcd. for C57H7 5 NgNaθ23S*7H 2 0 : C 48.16, H 6.31, N 7.88 Found : C 48.21, H 6.60, N 7.78 Example 88 IR (KBr) : 3350, 2954, 1668, 1629, 1538, 1511, 1454, 1249 cm "1 NMR (DMSO-dg, δ) : 0.88 (3H, t, 3=7.1Hz) , 0.96 (3H, d, 3=7.5Hz), 1.08 (2H, d, 3=5. Hz), 1.2-1.5 (6H, m) , 1.6-2.4 (8H, ), 2.6-2.7 (IH, ) , 3.1-3.3 (IH, m) , 3.6-4.5 (19H, ) , 4.7-5.3 (8K, m) , 6 - (IH, d, J=8.2Hz), 6.8-7.1 H, m) , 7.19 (IH, -. ■ , 7.3-7.5 (3H, ) , 7.75 (2H, d, 3=8.7Hz), 7.8-8.0 (4H, m) , 8.08 (IH, d, J=8.9Hz), 8.30 (IH, d, 3=7.7Hz), 8.7- 9.0 (3H, m) FAB-MASS : m/z = 1327 (M+Na + ) 6/11210 Elemental Analysiε Calcd. for C H7 N 0 G ? NaS*9H-- > 0 : C 46.65, K 6.25, N 9.54 Found : C 46.95, K 6.22, N 9.55 Example 89 IP (KB Brr)) : 3376, 2931, 2858, 1662, 1631, 1521, 1444, 1245, 1047 cm - 1 NMR (DMSO-dg, δ) : 0.97 (3H, d, J=6.7Hz), 1.09 (3ή' , d, 3=5.9Hz), 1.3-1.6 (6H, ) , 1.7-2.1 (5H, ) , 2.2-2.4 (3H, ), 2.5-2.6 (IH, m) , 3.21 (3H, s), 3.2-3.4 (3H, m), 3.6-4.5 (16K, ) , 4.79 (2K, d, 3=6.0Hz), 4.9-5.2 (5K, ) , 5.10 (IH, d, 3=3.6Hz), 5.18 (IK, d, 3=3.1Hz), 5.26 (IH, d, 3=4.5Hz), 5.53 (IH, d, 3=6.0Hz), 6.73 (IH, d, 3=8.2Hz) , 6.8-7.0 (2H, m) , 7.0-7.2 (3H, m) , 7.3-7.5 (3H, m) , 7.6-7.9 (8H, ) , 8.01 (2H, d, 3=8.4Hz), 8.12 (IH, d, 3=8.4Hz), 8.31 (IH, d, 3=7.7Hz), 8.79 (IH, d, 3=7.0Hz) , 8.85 (IK, s) FAB-MASS : m/z = 1357 (M+Na + ) Elemental Analyεiε Calcd. for C 2H 77 Ngθ23NaS*6.5H-,0 : C 50.10, H 6.20, N 7.66 Found : C 50.09, H 6.17, N 7.62 Example 90 IR (KBr) : 3363, 2937, 2869, 1646, 1444, 1255 c "1 NMR (DMSO-dg, δ) : 0.97 (3H, d, 3=6.7Hz), 1.08 (3H, d, 3=5.7Hz), 1.2-1.6 (10H, m) , 1.7-2.1 (5H, m) , 2.1- 2.4 (3H, m) , 2.5-2.7 (IK, m) , 3.20 (3H, ε) , 3.2-3.4 (IH, m) , 3.6-4.6 (16K, m) , 4.7-5.2 (8H, m) , 5.16 (IH, d, 3=3.1Hz), 5.24 (IH, d, 3=4.5Hz) , 5.54 (IH, d, 3=5.8Hz), 6.73 (IH, d, 3=6.2Hz), 6.8-7.0 (2H, ) , 7.1-7.4 (6H, ) , 7.97 (2H, d, 3=8.8Hz), 8.0-8.4 (6H, m) , 8.84 (IH, s) , 8.92 (IH, d, 3=7.0Hz) FAB-MASS : m/z = 1403.6 (M+Na + ) Elemental Analysis Calcd. for C5 H 77 N-, Q O-^NaS- δ^O : C 47.58, H 6.C2, 1, " 9.40 Found : C 47.72, K 6.12, N 9.42 Example 91 IF. (KBr) : 3350, 1668, 1654, 1625, 1537, 1521, 1245, 1047 cm "1 NMR (DMSO-dg, δ) : 0.9-1.1 (6H, m) , I.07 (3K, a, 3=5.7Hz), 1.4-2.0 (7H, m) , 2.2-2.5 (3H, ) , 2.5-2. Ό (IH, m) , 3.1-3.3 (IH, m) , 3.6-4.5 (16K, m) , 4.7-5.1 (7H, ) , 5.09 (IK, d, 3=5.6Hz), 5.16 (IH, d, 3=3. IHz), 5.25 (IK, d, 3=4.4Hz), 5.53 (IK, d, 3=6.0Hz), 6.73 (IH, d, 3=8.4Hz), 6.8-7.2 (6H, ; 7.2-7.5 (4H, m) , 7.5-7.8 (6H, ) , 8.11 (IH, d, 3=8.4Hz), 8.32 (IH, d, 3=7.7Hz), 8.54 (IH, d, 3=7.0Hz), 8.84 (IH, s) FAB-MASS : m/z = 1259 (M+Na ÷ ) Elemental Analyεis Calcd. for C 51 Kg Ngθ22 N aS-8H2θ : C 46.95, H 6.20, N 8.11 Found : C 47.20, K 6.23, N 8.28 Example 92 IR (KBr) : 3359, 2929, 2852, 1668, 1650, 1631, 1533, 1515 cm -1 NMR (DMSO-dg, δ) : 0.96 (3K, d, J=6.7Hz), 1.09 (3K, d, 3=6.IHz), 1.2-1.6 (5H, ) , 1.6-2.5 (10H, m) , 2.5- 2.6 (IK, π.) , 3.18 (IH, ) , 3.7-4.5 (15H, m) , 4.8- 5.2 (8H, m) , 5.17 (IH, d, J=3.IHz . 5.26 (IH, d, 3=4.5Hz), 5.55 (IH, d, 3=5.9Hz), ..73 (IH, d, J=8.1Hz), 6.81 (IH, s) , 6.8 ' (IH, s),7.05 (IH, s), 7.2-7.4 (3H, m) , 7.45 (2K, d, 3=8.2Hz), 7.96 (2K, d, 3=8.2Hz), 8.0-8.2 (4H, s) , 8.2-8.3 (IH, m) , 8.85 (IH, s), 8.9-9.0 (IH, d, J=7.0Hz) FAB-MASS : m/z = 1327.5 (M+Na) ÷ Elemental Analysis Calcd. for C5 H 6 N oθ21 s 2 Na ' 6H 2° : C 47.59, K 5.78, N 9.91 Found : C 47.89, H 5.76, N 9.93 Example 93 IR (KBr) : 335C, 1654, 1629, 1517, 1249, 1047 cm "1 NMP (DMSO-dg, δ< : 0.9-1.1 (6H, πυ , 1.11 (3K, d, 3=5.9Kz) , 1.6-2.0 (5H, s), 2.1-2.4 (3K, ε), 2.6-2. * (IK, m) , 3.1-3.3 (IK, m , 3.6-4.5 (16H, m) , 4.7-5.1 (7H, m) , 5.10 (IH, d, 3=5.6Hz), 5.17 (IH, d, 3=3. IHz), 5.25 (IH, d, 3=4.5H∑) , 5.55 (IH, d, 3=5.7Hz), 6. 7 -6.9 (3K, ) , ".0- .5 (6H, m) , 7.74 (2H, d, 3=8.8Hz;, 7.91 (2K, d, 3=8.5Hz), 8.1-8.4 (8H, _ 1 ( 6.84 (IK, s), 8.97 (IK, d, 3=7. OHz) FAB-MASS : m/z = 1363.5 (M+Na) * Elemental Analysis Calcd. for C-^ H N*, gC^SNa-SH^O : C 49.51, H 5.56, N 9.79 Found : C 49.39, H 5.63, N 9.77 Example 94 IR (KBr) : 3355, 2929, 2856, 1664, 1631, 1519, 1440, 1282 cm "1 NMR (DMSO-dg, δ) : 0.84 (3H, t, 3=6.7Hz), 0.96 (3H, d, 3=6.7HZ), 1.07 (3H, t, 3=5.6Hz), 1.2-1.5 (12H, ) , 1.7-2.0 (5H, m) , 2.2-2.4 (3H, m) , 2.5-2.7 (IH, rr.) , 2.94 (2H, t, 3=7.4Hz), 3.1-3.3 (IK, ) , 3.6-4.6 (14H, m) , 4.8-5.2 (7K, m) , 5.10 (IH, d, 3=3.6Hz), 5.17 (IH, d, 3=3. IHz), 5.26 (IK, d, 3=4.5Hz), 5.55 (IH, d, 3=5.9Hz), 6.73 (IH, d, 3=8.2Hz), 6.8-7.0 (2H, m) , 7.0-7.5 (4H, m) , 8.0-8.2 (5K, m) , 8.27 (IH, d, 3=7.7Kz), 8.85 (IK, s), 8.93 (IH, d, 3=7.0Hz) FAB-MASS : m/z = 1279 (M+Na * ) Elemental Analysis Calcd. for C53H73N2oC * 22 SNa '5-5 H 2° : C 46.93, H 6.24, N 10.33 Found : C 46.93, H 6.46, N 10.31 Example 95 IR (KBr) : 3363, 1673, 1648, 1538, 1253 cm "1 NMR (DMSO-dg, δ! : 0.92 (3H, t, 3=6.8Hz), 0.97 (3H, d, 3=6.8Hz), 1.10 (3H, d, 3=5.8Kz), 1.2-1.5 (6H, ) , 1.7-2.1 (5H, ) , 2.1-2.4 (3K, m) , 2.5-2.6 (IH, m) , 3.1-3.3 (IK, m) , 3.6-4.5 (I6K, m) , 4.7-5.1 (9K, ) , 5.16 (IH, d, 3=3.IHz ) , 5.24 (IH, d, 3=4.5Hz), 5.54 (IH, d, 3=5.8Hz), 6.73 (IH, d, 3=8.2Hz), 6.8-7.4 (8H, m) , 8.04 (2H, d, 3=8.8Hz), 8.13 (2H, d, 3=8.6Hz), 8.2-8.4 (4H, m) , 8.84 (IH, ε), 8.98 (IH, d, 3=7. OH∑) FAB-MASS : m/z = 1329.6 (M+Na) " Elemental Analyεiε Calcd. for C5gH 71 N2oθ23SNa-7K2θ : C 46.92, H 5.97, N 9.77 Found : C 46.86, H 5.99, N 9.77 Example 96 IR (KBr) : 3355, 2929, 1666, 1648, 1631, 1515, 1442, 1047 cm "1 NMR (DMSO-dg, δ) : 0.87 (3H, t, 3=6.7Hz), 0.97 (3H, d, 3=6.7Hz), 1.10 (3H, d, 3=5.8Hz) , 1.2-1.5 (10H, m) , 1.7-2.1 (5K, m) , 2.1-2.4 (3H, m) , 2.5-2.6 (IH, m) , 3.1-3.3 (IH, m) , 3.6-4.6 (16H, m) , 4.79 (2H, d, 3=5.9Hz), 4.8-5.2 (5K, m) , 5.09 (IH, d, 3=5.5Hz), 5.16 (IH, d, 3=3.IHz), 5.23 (IH, d, 3=4.5Hz) , 5.53 (IH, d, 3=5.9Hz), 6.73 (IH, d, 3=8.0Hz), 6.8-6.9 (2K, m) , 7.0-7.5 (6H, m) , 7.97 (2H, d, 3=8.8Hz), 8.0-8.3 (6H, ) , 8.83 (IK, s) , 8.88 (IH, d, 3=7.0Hz) FAB-MASS : m/z = 1373.5 (M+Na) " * " Elemental Analysis Calcd. for C5gH 7 5N oθ22 s 2 Na ' 6H 2° : C 47.73, H 6.01, N 9.60 Found : C 47.57, H 5.92, N 9.53 Example 97 IR (KBr) : 3361, 2925, 2852, 1666, 165C, 1631, 1536, 1452, 1049 cm "1 NMR (DMSO-dg, δ) : 0.87 (3H, t, 0.96 (3H, α, 3=6.7Hz), 1.08 (3H, d, 3=5.7Hz), 1.2-1.4 (11H, m) , 1.4-1.6 (2H, m) , 1.7-2.1 (5K, m) , 2.1-2.5 (5H, m) , 2.5-2. t (IK, mj , 3.1-3.3 (2K, mj , 3.7-4.5 (14H, n) , 4.7-5.C (7H, m) , 5.09 (IK, d, 3=5.6Hz) , 5.16 (IK, d, 3=3.IHz), 5.25 (IH, d, 3=4.5Hz), 5.54 (IK, d, 3=5.8Hz), 6.73 (IH, d, 3=8.2Hz), 6.8-7.0 (2K, d) , 7.04 (IK, s), 7.2-7.5 (3K, m) , 8.03 (4H, s) , 8.0- 6.3 (2H, m) , 8.84 (IK, s), 6.95 (IK, d, 3=7. OHz) FAB-MASS : m/z = 1321.9 (M+Na'~ Elemental Analysis Calcd. for C55H 5N 10 θ2 SoNa*5H2θ : C 47.54, H 6.17, N 10.08 Found : C 47.38, H 6.12, N 9.98 Example 98 IR (KBr) : 3374, 2937, 2875, 1658, 1629, 1531, 1436, 1255, 1047 cm "1 NMR (DMSO-dg, δ) : 0.9-1.11 (6H, m) , 1.09 (3H, d, 3=5.7Hz), 1.2-1.5 (4K, m) , 1.7-2.1 (5H, m) , 2.2-2.5 (3K, m) , 2.6-2.7 (IH, m) , 3.2-3.3 (IH, m) , 3.6-4.5 (16H, m) , 4.80 (2H, d, 3=5.8Kz), 4.8-5.2 (5H, m) , 5.10 (IH, d, 3=5.5Hz), 5.17 (IH, d, 3=3. OHz), 5.24 (IH, d, 3=4.5Hz), 5.53 (IH, d, 3=5.8Hz), 6.73 (IH, d, 3=8.2Hz), 6.8-7.0 (2H, m) , 7.06 (IH, s) , 7.10 (2K, d, 3=8.9Hz), 7.2-7.5 (3H, m) , 7.68 (IH, ε), 7.86 (2K, d, 3=8.8Hz), 8.0-8.4 (6H, m) , 3.84 (IK, s), 8.90 (IH, d, 3=7. OHz) FAB-MASS : m/z = 1314 (M+Na + ) Elemental Analysis Calcd. for C5 H7 Q Ngθ23NaS*6H 2 0 : C 48.03, H 5.90, N 9.00 Found : C 47.92, H 5.83, N 8.88 Example 9 IR (KBr) : 3345, 1646, 1635, 1531, 1257 cm "1 NMP (DMSO-dg, δ) : 0.97 (3H, d, J=ό.7Hz), 1.11 (3H, d, J=r. 7 Hz , 1.2-1.6 (10K, m) , 1.7-2.5 (6H, m) , 2.6- 2.7 (IK, m) , 3.21 (3H, s), 3.3-3.4 (IH, m) , 3.7-4.6 (16H, m) , 4.8-5.2 (8H, m) , 5.16 (IH, d, 3=3. IHz), 5.24 (IH, d, 3=4.5Hz), 5.55 (IH, d, 3=5.7Hz), 6.7- 6.9 (3H, m) , 7.0-7.5 (6H, m) , 8.0-8.3 (8H, m) , 8.84 (IK, s), 8.96 (IK, d, 3=7. OHz) FAB-MASS : m/z = 1387.7 (M+Na + ) Elemental Analyεiε Calcd. for C gH 77 2θθ24 NaS ' 6H 2° : C 46.09, H 6.09, N 9.51 Fc i : Z 47.81, H 5.83, N 9.38 ' Example 100 IR (KBr) : 3357, 1668, 1631, 1429, 1284, 1047 cm "1 NMR (DMSO-dg, δ) : 0.97 (3H, d, 3=6.7Hz), 1.09 (3H, d, 3=5.8Hz), 1.8-2.4 (6H, m) , 2.5-2.6 (IH, m) , 3.1-3.2 (IH, m) , 3.7-4.6 (14H, m) , 4.7-5.2 (7H, m) , 5.10 (IH, d, 3=5.5Hz), 5.17 ( " H, d, J=3.1Hz), 5.24 (IH, d, 3=5.5Hz), 5.53 (IH, d, 3=5.8Hz), 6.75 (IH, d, 3=8.2Hz), t.8-6.9 (2H, m) , 7.05 (IH, s) , 7.3-7.6 (9H, m) , 7.8-7.9 (4H, m) , 8.0-8.2 (5H, m) , 8.2-8.3 (IH, ) , 8.34 (IH, d, 3=9.3Hz), 8.7-8.8 (IH, m) , 8.85 (IH, s) FAB-MASS : m/z = 1332.7 (M+Na + ) Elemental Analy is Calcd. for C5 H 5 N2nθ22 SNa ' 8H 2 0 : C 47.93, H 5.62, N 9.64 7-und : C 47.83, H 5.53, N 9.56 Example 101 IR (KBr) : 3353, 29. 2856, 1666, 1631, 1612, 1496, 1440, 1259 cm "1 NMR (DMSO-dg, δ) : 0.87 (2H, t, 3=6.6Hz), 0.97 (3H, d, J=6.5Hz), 1.09 (3H, d - 5.9Hz), 1.2-1.5 (10H, m) , 1.7-2.1 (5H, ) , 2.2-: -> (3H, m) , 2.6-2.7 (IH, ) , /11210 - 235 - 3.1-3.2 (IH, m) , 3.6-4.5 (16K, m) , 4.7-5.C (3K, m) , 5.0-5.2 (5H, m) , 5.1C (IK, d, 3=3. IHz, , 5.26 (IK, d, 3=4.2Hz), 5.56 (IK, c. 3=5.5Hz), 6.-2 (IK, ά, 3=8. IHz), 6.8-7.0 (2H, mi, 7.05 (IH, s), 7.1-7.5 (5H, m) , 6.0-84 (8H, rr.) , 6.85 (IK, ε), 8.95 (IH, d, 3=7. OHz) FAB-MASS : m/z = 1357.3 (M+Na * Elemental Analysis Calcd. for : C 47.67, H 6.14, N 9.56 Found : C 47.63, H 6.42, N 9.52 Example 102 IR (KBr) : 3361, 1670, 1648, 1633, 1540, 1519, 1249 cm "1 NMR (DMSO-d 6 , δ) : 0.89 (3H, t, 3=7. OHz), 0.97 (3H, d, 3=6.8Hz), 1.10 (3H, d, 3=5.7Hz), 1.2-1.5 (6H, m) , 1.6-2.4 (8H, m) , 2.5-2.7 (IH, m) , 3.1-3.3 (IH, m) , 3.6-4.5 (16H, ), 4.80 (2K, d, 3=5.8Hz) , 4.8-5.2 (5K, m) , 5.10 (IK, d, 3=5. Hz) , 5.18 (IK, d, 3=3.IHz), 5.25 (IH, d, 3=4.3Hz), 5.55 (IH, d, 3=5.7Hz), 6.73 (IH, d, 3=8.2Hz), 6.9-7.0 (2K, m) , 7.0-7.5 (6H, m) , 8.02 (IH, d, 3=5.3Hz), 6.0-8.4 (4H, m) , 8.42 (2H, d, 3=8.4Hz), 8.48 (2H, d, 3=8.9H∑), 8.8-9.0 (3K, m ) FAB-MASS : m/z = 1339.3 (M+Na " ) Elemental Analysis Calcd. for C H 7 3N2oθ22 SNa ' 6H 2 c : C 48.87, H 6.01, N 9.83 Found : C 49.16, K 5.92, N 9.86 Example 103 IR (KBr) : 3350, 2971, 2859, 1672, 1629, 1537, 1442, 1247, 1047 cm -1 NMR (DMSO-dg, δ) : 0.96 (3H, d, 3=6.8Hz), 1.0-1.2 (6K, m) , 1.2-1.6 (12H, m) , 1.7-2.5 (8H, ) , 2.5-2.6 (IH, ) , 3.2-3.6 (7H, m) , 3.7-4.5 (16K, m) , 4.76 (2H, d. 3=5.6Hz), 4.8-- 1 (5H, ; , 5.09 (IK, d, 3=5.5Hz;, 5.16 (IK, d, 3=3. IHz , , 5.23 (IK, d, 3=5.5Hz,, 5.51 (IH, a, 3=5.9Hz), 6.73 (IH, o, 3=8.2Hz,, 6.8-6.9 (2H, m) , 7.0-7.1 (3H, m) , 7.3-7. r (3H, m) , 7.67 (2H, d, 3=6.9Hz), 7.71 (2H, d, 3 .9Hz), 7. 5 (2K, d, 3=8.4Hz), 8.05 (IH, d, 3=7. OHz), 8.23 (IH, d, 6.84 (IK, ε) FAB-MASS : m/z = 1377.1 (M+Na + ) Elemental Analysis Calcd. f r Cg Q H 3Ng024NaS*5H 2 0 : C 49.86, H 6.49, N 7.75 Found : C 49.74, H 6.73, N 7.66 Example 104 IR (KBr) : 3349, 2937, 2858, 1672, 1629, 1537, 1444, .249, 1047 cm "1 NMR (DMSO-dg, δ) : 0.96 (3H, d, 3=6.7Hz), 1.08 (3H, d, 3=5.6Hz), 1.2-1.7 (14H, m) , 1.7-2.1 (5H, m) , 2.1- 2.4 (5H, ) , 2.5-2.6 (IH, m) , 3.1-3.2 (IH, m) , 3.4- 3.6 (4H, m) , 3.7-4.5 (16K, m) , 4.77 (2H, d, 3=5.7Hz), 4.8-5.2 (5H, it), 5.09 (IH, d, 3=5.6Hz), 5.16 (IH, d, J=3.1Hz), 5.24 (IH, d, 3=4.5Hz), 5.51 (IH, d, 3=5.8Hz), 6.73 (IH, d, 3=8.2Hz), 6.8-6.9 (2H, m) , 7.0-7.1 (3H, ) , 7.3-7.5 (3H, m) , 7.6-7.8 (4H, ), 7.96 (2K, d, 3=8.4Hz), 8.10 (IH, d, 3=8.4Hz), 8.24 (IH, d, 3=7.7Hz), 8.71 (IH, d, 3=7.0Hz), 8.89 (IH, s) FAB-MASS : m/z = 1386.5 (M+Ka + ) Elemental Analysis Calcd. for Cg-,H 8 2N θ23NaS*6H 9 0 : C 49.76, H 6.43, N 8.56 Found : C 49.99, H 6.39, N 8.52 Example 105 IR (KBr) : 3350, 2933, 2856, 1664, 1631, 1604, 1511, 1450, 1243, 1045 cm "1 NMR (DMSO-d 6 , δ) : 0.86 (3H, t, 3=6.7Hz), 0.96 (3H, d. 3=6.5Hz), 1.05 (3H, d, 3=5.7Hz), 1.2-1.5 (8K, m) , 1.6-2.0 (5K, m) , 2.1-2.4 (3H, m) , 2.5-2.6 (IK, m) , 3.0-3.3 (5H, m) , 3.6-4.4 (20H, ) , 4.7-5.1 (7K, m) , 5.10 (IK, d, 3=5.5Hz), 5.16 (IK, d, 3=3. IHz) , 5.27 (IK, d, 3=4.5Hz), 5.51 (IK, d, 3=6. OHz) , 6.7- 7 .1 (9K, m) , 7.2-7.5 (3H, rn) , 8.0-8.2 (2K, rr.) , 8.2-8.4 (IK, ) , 8.4-8.6 (IK, ) , 8.66 (IK, d, 3=2.2Kz), 8.85 (IK, s) FA3-MASS : m/z = 1360 (M+Na * . Elemental Analysis Calcd. for C5gHg-N θ2? SNa ' H 2° : C 48.16, H 6.41, N 10.65 Found : C 47.91, H 6.31, N 10.56 Example 106 IR (KBr) : 3369, 3345, 2935, 1672, 1629, 1511, 1245, 1047 cm "1 NMR (DMSO-dg, δ) : 0.96 (3H, c, 3=6.7Hz), 1.06 (3H, d, 3=5.8Hz), 1.3-1.6 (10H, m) , 1.6-2.C (5H, ) , 2.1- 2.4 (3H, m) , 2.5-2.6 (IK, m) , 3.20 (3H, s), 3.28 (2H, t, 3=6.4Hz), 3.1-3.4 (5H, m) , 3.7-4.5 (20K, ) , 4.7-5.1 (7H, ) , 5.08 (IH, d, 3=5.5Hz), 5.15 (IH, d, 3=3.IHz), 5.23 (IH, d, 3=4.5Hz), 5.48 (IK, d, 3=5.8Hz), 6.73 (IH, d, 3=8.2Hz), 6.82 (2H, d, 3=9.IHz), 6.94 (2H, d, 3=9.IHz), 6.9-7.0 (IH, m) , 7.04 (IH, s), 7.3-7.5 (3K, ) , 8.0-8.1 (2H, m) , 8.27 (IH, d, J=7.7Hz), 8.49 (IH, d, 3=7.OHz), 8.66 (IH, d, 3=2.2Hz), 8.84 (IH, s) FAB-MASS : m/z = 1404 (M+Na + ) Example 107 IR (KBr) : 3357, 1647, 1631, 1537, 1444, 1249, 1049 cm -1 NMR (DMSO-dg, δ) : 0.9-1.1 (6K, ) , 1.09 (3H, d, J=5.9Hz), 1.6-2.4 (8H, ) , 2.4-2.5 (IH, m) , 3.1-3.3 (IH, ) , 3.6-4.5 (16H, m) , 4.8-5.2 (7H, m) , 5.10 /11210 - 241 - (IH, d, 3=5.6Hz), 5.1 * (IH, d, 3=3. IHz), 5.25 (IK, d, 3=4.5Hz), 5.55 (IH, ά, 3=5.9Hz), 6.73 (IK, d, , 6.8-7.0 (2H, m , 7.0-7.6 (6H, ) , 7.73 (2H, d, 3=8.7Hz), 7.86 (2H, d, 3=8.5Hz), 8.0-8.3 '8H, m, , 6.84 (IK, s , , 8.9-9.C (IK, m) FAB-MASS : m/z = 13 7 9. (M+Na) * Elemental Analysis Calcd. fcr CcgHggN*. Q G2 ? S*-,Na*6H2θ : C 48.36, H 5.57, N 9.56 Found : C 48.18, H 5.60, N 9.36 The Object Compoundε (108) to (117) were obtained according to a similar manner to that of Example 27. Example 106 IR (KBr) : 3350, 2933, 1670, 1627, 1521, 1436, 1272, 1047 cm "1 NMR (DMSO-dg, δ) : 0.85 (3H, t, 3=6.7Hz), 0.92 (3H, d, 3=6.7Hz), 1.1-1.4 (11H, m) , 1.7-2.4 (9H, m) , 3.1- 3.2 (IH, m) , 3.5-5.4 (27H, m) , 6.6-7.2 (8H, ) , 7.5-7.8 (3K, m) , 7.8-8.C (3K, m) , 8.1-8.8 (3H, m) FAB-MASS : m/z = 1249.4 (M+Na + ) Elemental Analysis Calcd. for C ?H7 *< N2oθ21 NaS ' 7H 2 0 : C 46.15, H 6.33, N 10.35 Found : C 46.12, H 6.35, N 10.24 Example 1Q9 IR (Kbr pelet) : 3361, 2933, 2856, 1670, 1652, 1616, 1540, 1506, 1448, 1261, 1047 cm "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, 3=6.6Hz), 0.97 (3H, d, 3=6.8Hz), 1.12 (3H, d, 3=6.8Kz) , 1.2-1.5 (10H, m) , 1.7-2.0 (5H, ) , 2.2-2.6 (4H, m) , 3.1-3.2 (IH, m) , 3.7-4.4 (16H, ) , 4.8-5.3 (10H, m) , 5.59 (IH, d, 3=6.OHz), 6.7-6.9 (3H, m) , 7.0-7.4 (7H, m) , 7.8-8.2 (4H, m), 8.8-9.0 (2H, ) FAB-MASS : m/z = 128J.5 (M+Na + ) Elemental Analysiε Calcd. for C5 4 H 7 N θ23NaS-7H2θ : C 46.45, H 6.21, N 9.03 Found : C 46.68, K 6.44, N 9.03 Example 110 IR (KBr) : 3350, 2931, 1670, 1627, 1540, 1436, 1276, 1047 cm "1 NMR (DMSO-dg, δ) : 0.87 (3H, t, 3=6.8Hz), 0.93 (2H, d, 3=8.8Hz), 1.03 (2H, d, 3=5.9Hz), 1.2-1.4 (4H, m) , 1.5-1.7 (2H, m) , 1.7-2.1 (3H, m) , 2.1-2.4 (3H, m) , 2.6-2.7 (3H, m) , 3.1-3.3 (IH, m) , 3.6-4.5 (17H, m) , 4.7-5.4 (8H, m) , 6.73 (IH, d, 3=8.2Hz), 6.83 (2H, d, 3=8.2Hz), 7.0-7.1 (IH, m) , 7.2-7.5 (5H, m) , 7.65 (2H, d, 3=8.2Hz), 7.74 (2H, d, 3=8.4Hz), 7.98 (2H, d, 3=8.4Hz), 8.08 (IH, d, 3=8.5Hz), 8.25 (IH, d, 3=8.5Hz), 8.74 (IH, d, 3=7.6Hz), 8.7-9.0 (IH, br) FAB-MASS : m/z = 1231.2 (M+Na + ) Elemental Analyεis Calcd. for C53H gNgθ22 N «-S'3H2θ : C 50.39, H 5.98, N 8.87 Found : C 50.34, H 6.25, N 8.90 Exam le \ \ l IR (KBr) : 3353.6, 1670.1, 1652.7, 1623.8 cm "1 NMR (DMSO-d 6 , δ) : 0.96 (3H, d, J=6.7Hz), 1.07 (3H, d, 3=5.6Hz), 1.20-1.62 (8H, m) , 1.62-2.00 (5H, m) , 2.10-2.65 (4H, m) , 3.20 (3H, s) , 3.08-3.40 (IK, m) , 3.30 (2H, t, 3=6.5Hz), 3.53-4.50 (15H, ) , 4.68- 5.13 (9H, m) , 5.16 (IH, d, 3=2.9Hz), 5.26 (IH, d, 3=4.5Hz), 5.53 (IH, d, 3=5.9Hz), 6.68-6.95 (4H, m) , 6.95-7.11 (3H, ) , 7.20-7.52 (3H, ) , 7.55-7.95 (7H, ) , 8.13 (IH, d, 3=8.4Hz), 8.31 (IH, d, J=7.7Hz), 8.53 (IH, d, 3=7.OHz), 8.85 (IH, s) FAB-MASS : m/z = 1331.5 (M+Na-1) Elemental Analysis Calcd. for C5 8 H77N 8 Naθ23S-6H 2 0 : C 49.15, H 6.33, N 7.91 Found : C 49 H 6.53, N 7.84 Example 112 IR (KBr) : 3350, 2937, 1673, 1646, 1631, 1538, 1519, 1456, 1247, 1049 cm "1 NMR (DMSO-dg, δ) : 0.97 (3H, d, 3=6.6Hz), 1.07 (3H, d, 3=5.7Hz), 1.3-2.4 (25K, m) , 2.5-2.6 (IH, m) , 3.2- 3.4 (IH, m) , 3.5-4.6 (20H, m) , 4.8-5.7 (11H, m) , 6.73 (IH, d, 3=8. OHz), 6.9-7.0 (2H, m) , 7.0-7.2 (3H, m) , 7.3-7.6 (3H, m) , 7.74 (2H, d, 3=8.5Hz), 7.77 (2H, d, 8.3Hz), 8.02 (2H, d, 3=8.3Hz), 8.13 (IK, d, 3=8.4Hz), 8.30 (IK, d, 3=7.7Hz), 8.77 (IK, d, 3=7. OHz), 8.85 (IH, s) FAB-MASS : m/z " = 1389 (M+Na + ) Elemental Analyεiε Calcd. for Cg2Hg3Ngθ24NaS*7H 2 0 : C 49.06, H 6.55, N 7.50 Found : C 49.03, H 6.54, N 7.56 Example 113 NMR (DMSO-dg, δ) : 0.84 (3H, t, 3=6.7Hz), 0.96 (3H, d, 3=6.7Hz), 1.07 (3H, d, 3=5.9Hz), 1.1-1.3 (14H, m) , 1.7-2.1 (5H, ) , 2.2-2.5 (3H, m) , 2.6-2.7 (IH, m) , 3.1-3.3 (IH, m) , 3.7-4.5 (16H, m) , 4.7-5.1 (7H, m) , 5.10 (IH, d, 3=5.5Hz), 5 : 6 ( IE, d, 3=3.IHz), 5.25 (IH, d, 3=4.5Hz), 5.49 (11*- d, 3=5.7Hz), 6.53 (IH, d, 3=3.IHz), 6.77 (IH, d, 3=8.2Hz), 6.8-6.9 (2H, m) , 7.05 (IH, m) , 7.31 (IH, d, 3=8.IHz), 7.4-7.6 (4H, m) , 7.70 (IH, d, 3=6.7Hz), 8.08 (IH, d, 3=8.4Hz), 8.18 (IH, s) , 8.31 (IH, d, 3=7.7Hz), 8.57 (IH, d, 3=7.OHz , 8.85 (IH, s) FAB-MASS : m/z = 1264 (M+Na + ) Elemental Analysis Calcd. for C54H7 N θ2 N*aS-6H 2 0 : C 48.03, H 6.57, N 9.34 Found : C 48.02, H 6.61, N 9.28 Example 114 IR (KBr : 3350, 2937, 1668, 1631, 1537, 1247, 1047 cm "1 NMR (DMSO-a,-, 5 : 0.85 (3H, t, 3=7.4Hz), 0.96 (3K, d, 3=6.5Hz), 1.C7 (3H, d, 3=5.7Hz), 1.3-1.7 (7H, m) , 1.7-2.1 (5H, m) , 2.2-2.4 (3H, m) , 2.6-2.7 (IK, m) , 3.0-3.6 (I6H, m) , 3.8-4.6 (11H, ) , 4.7-5.3 (6H, m) , 6. ~ 3 (IH, d, 3=8.2Hz ) , 6.8-7.0 (2H, m) , 7.0-7.2 (3H, m) , 7.3-7.5 (3H, m) , 7.6-7.8 (4H, m) , 7.96 (2H, d, 3=8.3Hz), 8.11 (IH, d, 3=8.2Hz), 8.26 (IH, d, 3=7.6Hz), 8.6-9.0 (2K, m) FAB-MASS : m/z = 1319.4 (M+Na * ) Elemental Analysis Calcd. for : C 47.50, H 6.50, N 7.77 Found : C 47.72, H 6.85, N 7.85 Example 115 IR (KBr) : 3350, 1666, 1631, 1546, 1276, 1247 cm "1 NMR (DMSO-dg, δ) : 0.97 (3H, d, 3=7.5Hz) , 1.08 (3H, d, 3=5.7Hz), 1.4-1.6 (4H, ) , 1.6-2.1 (5H, m) , 2.1-2.4 (3H, m) , 2.5-2.6 (IH, ) , 3.1-3.3 (IH, m) , 3.23 (3H, s), 3.3-3.5 (2H, m) , 3.7-4.5 (16H, m) , 4.79 (2H, d, 3=6.2Hz), 4.8-5.1 (5H, m) , 5.11 (IH, d, 3=5.6Hz), 5.18 (IH, d, 3=3. IHz), 5.26 (IH, d, 3=4.4Hz), 5.54 (IH, d, 3=5.7Hz), 6.73 (IH, d, 3=8. IHz), 6.8-7.0 (2H, m) , 7.0-7.1 (3H, ) , 7.3-7.5 (3H, m) , 7.6-7.9 (8H, m) , 8.01 (2H, d, 3=8.4Hz), 8.08 (IH, d, 3=8. Hz) , 8.32 (IH, d, 3=7.7Hz), 8.80 (IH, d, 3=7.0Hz), 8.85 (IH, s) FAB-MASS : m/z = 1353.9 (M+Na + ) Elemental Analysis Calcd. for C 0 H 7 5Ngθ23NaS*9.5H 2 0 : C 47.96, H 6.31, N 7.46 Found : C 47.97, H 6.25, N 7.41 Example 116 IR (KBr) : 3450, 2935, 1675, 1650, 1540, 1513, 1454, 1047 cm -1 NMR (DMSO-dg, δ) : 0.97 (3K, d, 3=6.7Hz) , 1.09 (3H, d, 3=5.9Hz) , 1.60 (6H, s), 1.7-2.4 (6H, ) , 2.5-2.6 (IH, m) , 3.1-3.6 (5H, m) , 3.7-4.5 (14K, ) , 4.7-5.0 (3K, m) , 5.0-5.2 (4H, m) , 5.11 (IH, d, 3=5.5Hz) , 5.18 (IK, d, 3=3. IHz), 5.26 (IH, d, 3=4.5Hz), 5.56 (IH, d, 3=6. OHz), 6.8-7.5 (9H, m) , 7.84 (2H, d, 3=8.8Hz), 8.0-8.4 (6H, m) , 8.85 (IK, s) , 8.91 (IK, d, 3=7. OHz) FAB-MASS : m/z = 1328 (M+Na) + Elemental Analyεiε Calcd. for C55Hg N °21 s 2 Na ' 8H 2° : C 45.55, H 5.84, N 10.62 Found : C 45.62, H 5.70, N 10.54 Example 117 IR (KBr) : 3350, 2939, 1664, 1627, 1531, 1446, 1249, 1049 cm -1 NMR (DMSO-dg, δ) : 0.8-1.0 (6H, ) , 1.4-1.9 (9H, m) , 2.0-2.5 (4H, ) , 3.1-3.2 (IH, m) , 3.22 (3H, ε), 3.3-3.4 (2H, ) , 3.51 (2H, s) , 3.6-4.4 (16H, m) , 4.7-5.2 (7K, ), 5.07 (IH, d, 3=5.6Hz), 5.17 (IK, d, 3=3. IHz), 5.2 ' IH, d, 3=4.5Hz), 5.54 (IH, d, 3=5.9Hz), 6.7-6.8 (3H, ) , 7.0-7.4 (8K, ) , 7.5-7.7 (4H, ) , 7.70 (4H, s) , 8.1-8.2 (2H, m) , 8.51 (IH, d, 3=7. OHz), 8.83 (IH, s) FAB-MASS : m/z = 1367.6 (M+Na + ) Elemental Analysis Calcd. for C H77Ng0 7 3SNa*6.5H 2 0 : C 50.01, K 6.20, N 7.66 Found : C 50.30, 1 -.50, N 7.75 Example 119 To a solution of The Object Compound (61) (0.25 g) in methanol (50 ml) was added dry 10% palladium on carbon (0.2 g) and stirred for 6 hours under hydrogen atmosphere. The palladium on carbon was filtered off, and the filtrate was evaporated under reduced preεεure to give Object Compound 118 (179 mg) . IR (KBr) : 3400, 1668.1, 1627.6 cm "1 NMR (DMSO-dg, δ) : 0.92 (3H, d, 3=6.7Hz), 1.1-2.45 (40H, m) , 3.20 (3H, ε), 3.28 (2H, t, 3=6.5Hz), 3.0- 3.4 (IK, m) , 3.5-4.7 (14K, m) , 4.95-5.5 (12H, m) , 6.55 (IH, d, 3=8.4Hz), 6.84 (IK, s), 6.86 (IK, d, 3=8.4Hz), 7.0-7.3 (4H, m) , 7.9-8.3 (4H, m) FAB-MASS : m/z = 1292 (M+Na) Elemental Analyεiε Calcd. for C 54 HggNgθ22SNa-5H2θ : C 47.67, H 7.26, N 9.26 Found : C 47.72, K 7.35, N 8.95 The Object Compounds (119) to (121) were obtained according to a similar manner to that of Example 118. Example 119 NMR (DMSO-dg, δ) : 0.87 (3H, t, 3=6.6Hz), 1.00 (3H, d, 3=7.3Hz), 1.03 (3H, d, 3=6. OHz), 1.2-1.5 (4H, m) , 1.5-2.0 (5H, ) , 2.1-2.7 (8H, m) , 3.17 (IH, m) , 3.6-4.5 (14H, m) , 4.65-5.7 (12H, m) , 6.72 (IH, d, 3=8. IHz), 6.75 (IH, s) , 6.80 (IH, d, 3=8. IHz), 7.05 (IK, s), 7.1-7.7 (15H, m) , 8.0-8.6 (4H, m) , 6.85 (IH, s) FAB-MASS : m/z = 1274 (M+Na) Elemental Analysis Calcd. for C55H 74 N θ22SNa*7H- ? 0 : C 47.93, N 6.43, N 9.15 Found : C 48.12, N 6.56, N 9.03 Example 12Q IR (KBr) : 3355.5, 1672.0 1629.6 cm -1 NMR (DMSO-d 6 , δ) : 0.86 (3H, t, 3=6.6Hz) , 0.98 (3H, d, J=6.5Hz), 1.03 (3H, d, 3=6.OHz), 1.2-2.6 (21H, m) , 3.18 (IH, m) , 3.6-4.5 (16H, m) , 4.65-5.55 (12H, m) , 6.6-7.5 (10H, m) , 8.0-8.6 (4H, m) , 8.89 (IH, ε) FAB-MASS : m/z = 1256 (M+Na) Example 12- IR (KBr) : 3357.5, 1660.4, 1629.6, 1249.6 cm "1 NMR (DMSO-dg, δ) : 0.86 (3H, t, 3=6.6Hz), 0.96 (3H, d, 3=6.8Hz), 1.03 (3H, d, 3=6. OHz), 1.1-1.5 (12K, m) , 1.6-2.0 (5H, m) , 2.0-2.5 (4K, m) , 3.07 (IH, m) , 3.5-4.5 (16H, m) , 4.6-5.6 ' "H, m) , 6.72 (IH, d, 3=8. IHz), 6.7-6.9 (4H, m) , .04 (IH, s), 7.16 (IH, ε), 7.1-7.5 (2H, m), 7.25 (2H, d, 3=8.6Hz), 8.0-8.2 (3H, m) , 8.46 (IH, d, 3=7Hz), 8.84 (IK, ε) FAB-MASS : m/z = 1256 (M+Na) Elemental Analyεis Calcd. for C52H7gN θ22SNa*7H 2 0 : C 45.91, H 6.67, N 9.27 Found : C 45.98, K 6.67, N 9.10 Example 122 A solution of Object Compound (11) (795 mg) in water (16 ml) was left for 240 hours. The solution was subjected to column chromatography on ODS (YMC-gel ODS-AMS50) and eluted with 25?, CH3CN/H 9 O. The fractions containing Object Compound were combined and the acetonitrile was removed under reduced pressure. The residue was lyophiiized to give Object Compound (123) (38 mg) . IR (KBr) : 3361, 2956, 2875, 1668, 1627, 1521, 1249, 1047 cm "1 NMR (DMSO-d 6 , δ) : 0.8-1.5 (19H, ) , 1.6-2.4 (13K, m) , 3.1-3.2 (IH, ), 3.5-4.1 (12H, m) , 4.1-4.7 (10H, m) , 4.9-5.6 (5H, ) , 5.98 (IH, d, 3=10.6Hz), 6.36 (IH, d, 3=10.6Hz), 6.7-7.3 (12H, ) , 7.4-8.0 (7H, m) FAB-MASS : m/z = 1273.1 (M+Na + ) Elemental Analysis Calcd. for : C 45.58, H 6.47, N 7.73 Found : C 45.83, K 6.26, N 7.75 The Object Ccmpdund (123) was dbtained according to a similar manner to that of Example 118. Example 123 IR (KBr) : 3349.7, 1670.1, 1627.6 cm "1 NMR (DMSO-dg, δ) : 0.67 (3H, t, 3=7.2Hz), 0.96 (3H, d, 3=6.7Hz), 1.13 (3H, d, 3=5.7Hz), 1.18-1.55 (10H, m) , 1.58-2.08 (5H, m) , 2.08-2.90 (4H, m) , 2.90-3.30 (2H, m) , 3.60-4.50 (17K, ) , 4.70-5.70 (12H, nt) , 6.65-7.60 (11H, m) , 7.80 (2H, br s), 7.95-8.23 (2H, m) , 8.75 (IH, d, 3=7. OHz), 8.85 (IH, ε) FAB-MASS : m/z = 1114.4 (M-S0 4 -2) Elemental Analyεis Calcd. for C5 H 7 7Ngθ22S-6H2θ : C 47.88, H 6.88, N 9.66 Found : C 47.60, H 6.74, N 9.53 The following compound (124) was obtained according to a similar manner to that of Example 1. Example 124 IR (KBr) : 3324, 2937, 2873, 1664, 1629, 1442, 1257 cm "1 NMR (DMSO-dg, δ) : 0.91 (3H, t, 3=7. IHz), 0.96 (3H, d, 3=6.7Hz), 1.09 (3H, d, 3=5.7Hz), 1.3-1.5 (4H, ) , 1.7-2.6 (9H, m) , 3.1-3.3 (IH, m) , 3.7-4.6 (16H, m) , 4.7-5.1 (7H, m) , 5.11 (IH, d, 3=5.6Hz), 5.17 (IH, d, 3=3. IHZ), 5.26 (IH, d, 3=4.5Hz), 5.55 (IH, d, 3=5.8Hz), 6.7-6.9 (3H, m) , 7.0-7.6 (6H, m) , 7.97 (2H, d, 3=8.8Hz), 8.0-8.4 (6H, m) , 8.85 (IH, s) , 8.92 (IH, d, 3=7. OHz) FAB-MASS : m/z = 1331 (M+Na + ) Elemental Analysis Calcd. for : C 45.45, H 5.89, N 9.64 Found : C 45.71, H 5.68, N 9.60

Claims: CLAIMS 1. A polypeptide compound of the following general formula : wherein R 1 is lower alkanoyl εubstituted with unsaturated 6-membered heteromonocyclic group containing at least one nitrogen atom which may have one or more suitable substituent (s) ; lower alkanoyl εubεtituted with 1,2,3,4-tetrahydroiεoquinoline which may have one or more suitable substituent(s) ; lower alkanoyl substituted with unsaturated condensed heterocyclic group containing at leaεt one oxygen atom which may have one or more suitable substituent(s) ; lower alkanoyl substituted with unsaturated condensed heterocyclic group containing 1 to 3 sulfur atom(s) which may have one cr more suitable εubεtituent (s) ; lower alkanoyl substituted with unsaturated condenεeo heterocyclic 5 group containing 2 or more nitrogen atom(ε) which may have one or more suitable substituent (s) ; lower alkanoyl εubεtituted with εaturated 3 to 8 membered 10 heteromonocyclic group containing at least one nitrogen atom which may have one or more suitable substituent (s) ; ar(lower;alkenoyl substituted with aryl which may have one cr more 15 suitable substituent (s) ; naphthyl (lower)alkenoyl which may have one or more higher alkoxy; lower alkynoyl which may have one cr more suitable εubεtituent (ε) ; 20 (C2~C )alkanoyl εubεtituted with naphthyl having higher alkoxy; ar(C2 _ C )alkanoyl subεtituted with aryl having one or more εuitable substituent (s) , in which ar(C 2 -Cg)- 25 alkanoyl may have one cr more suitable substituent (s) ; aroyl substituted with heterocyclic group which may have one or more suitable substituent (s) , in which aroyl 30 may have one cr more suitable substituent(s) ; aroyl substituted with aryl having heterocyclic(higher) alkoxy, in which heterocyclic group may have one or more 35 suitable substituent (s) ; aroyl substituted with aryl having lower alkoxy(higher) alkoxy; aroyl substituted with aryl having lower alkenyl (lower)alkoxy; 5 aroyl subεtituted with 2 lower alkoxy; aroyl subεtituted with aryl having lower alkyl; aroyl εubr uted with aryl having 10 higher alkyl aryloxy(lowt_; alkanoyl which may have one or more suitable εubεtituent (s) ; ar(lower)alkoxy(lower) alkanoyl which may have one or more εuitable 15 substituent (ε) ; arylamino(lower) alkanoyl which may have one or more suitable substituent (s) ; lower alkanoyl substituted with 20 pyrazolyl which has lower alkyl and aryl having higher alkoxy; lower alkoxy(higher)alkanoyl, in which higher alkanoyl may have one or more suitable substituent (s) ; 25 aroyl substituted with aryl having heterocyclicoxy, in which heterocyclicoxy may have one or more suitable substituent (s) ; aroyl substituted with 30 cyclo(lower)alkyl having lower alkyl; indolylcarbonyl having higher alkyl; naphthoyl having lower alkyl; naphthoyl having higher alkyl; naphthoyl having lower 35 alkoxy(higher)alkoxy; aroyl substituted with aryl having lower alkoxy(lower)alkoxy(higher) - alkoxy; aroyl substituted with aryl having lower alkoxy(lower) alkoxy; aroyl substituted with aryl which has aryl having lower alkoxy; aroyl subεtituted with aryl which haε aryl having lower alkoxy(lower)alkoxy; aroyl εubstituted with aryl having heterocyclicoxy(higher) alkoxy; aroyl εubεtituted with aryl having aryloxy(lower)alkoxy; aroyl substituted with aryl having heterocycliccarbonyl (higher) alkoxy; lower alkanoyl subεtituted with oxazolyl which haε aryl having higher alkoxy; lower alkanoyl substituted with furyl which has aryl substituted with aryl having lower alkoxy; lower alkanoyl substituted with triazolyl which has oxo and aryl having higher alkyl; higher alkanoyl having hydroxy; higher alkanoyl having ar(lower) alkyl and hydroxy; 3-methyl-tridecenoyl; or (C 2 -Cg)alkanoyl substituted with aryl having higher alkoxy, in which (C 2 ~Cg)- alkanoyl may have amino or protected amino, and a pharmaceutically acceptable salt thereof. compound of claim 1, wherein ε lower kanoyl εubstituted with unεaturated 6-membeι_d heteromonocyclic group containing at leaεt one nitrogen atom which may have 1 to 3 εubεtituent (s) εelected from the group conεisting of lower alkoxy, higher alkoxy, lower alkyl, higher alkyl, higher alkoxy (lower) alkyl, phenyl having lower alkoxy, phenyl having higher alkoxy, naphthyl having lower alkoxy, naphtnyl having higher alkoxy, phenyl having lower alkyl, phenyl having higher alkyl, naphthoyl having higher alkoxy, phenyl subεtituted with phenyl having lower alkyl, 3 to 8-membered εaturated heteromonocyclic group containing at leaεt one nitrogen atom which may have phenyl having higher alkoxy, phenyl εubεtituted with phenyl having lower alkoxy, 3 to 8-membered saturated heteromonocyclic group containing at least one nitrogen atom which may have phenyl having lower alkoxy(higher) alkoxy, 3 to 8-membered saturated heteromonocyclic group containing at least one nitrogen atom which may have phenyl having lower alkoxy, and oxo; lower alkanoyl substituted with 1,2,3,4- tetrahydroiεoquinoline having higher alkoxy and lower alkoxy carbonyl; lower alkanoyl substituted with unsaturated condensed heterocyclic group containing at least one oxygen atom which may have 1 to 3 substituent (s) selected fr^m tr . group consiεting of 1 /er alkoxy, higher al.-oxy, lower alkyl, highr.r alkyl, higher alkoxy(lower) alkyl, phenyl having lower alkoxy, phenyl having higher alkoxy. naphthyl having lower alkoxy, naphthyl having higher alkoxy, phenyl having lower alkyl, phenyl having higher alkyl, naphthoyl having higher alkoxy, phenyl subεtituted with phenyl having lower alkyl, unsaturated 6-membered heteromonocyclic group containing at leaεt one nitrogen atom which may have higher alkoxy, and oxo; lower alkanoyl εubεtituted with unsaturated condensed heterocyclic group containing 1 to 3 sulfur atom(s) wnich may have 1 to 3 substituent (s) selected from the group consiεting of lower alkoxy, higher alkoxy, lower alkyl, higher alkyl, higher alkoxy(lower) alkyl, phenyl having lower alkoxy, phenyl having higher alkoxy, naphthyl having lower alkoxy, naphthyl having higher alkoxy, phenyl having lower alkyl, phenyl having higher alkyl, naphthoyl having higher alkoxy, phenyl substituted with phenyl having lower alkyl, and oxo; lower alkanoyl substituted with unsaturated condensed heterocyclic group containing 2 or more nitrogen atoms which may have 1 to 3 substituent(s) selected from the group containing of lower alkoxy, higher alkoxy, lower alkyl, higher alkyl, higher alkoxy(lower)alkyl, phenyl having lower alkoxy, phenyl having higher alkoxy, naphthyl having lower alkoxy, naphthyl having higher alkoxy, phenyl having lower alkyl, phenyl having higher alkyl, naphthoyl having higher alkoxy, phenyl substituted with phenyl having lower alkyl, and oxo; or lower alkanoyl substituted with saturated 3 to 8-membered heteromonocyclic group containing at least one nitrogen atom which may have 1 to 3 εubεtituent (s) εelected from the group conεiεting of lower alkoxy, higher alkoxy, lower alkyl, higher alkyl, higher alkoxy (lower) alkyl, phenyl having lower alkoxy, phenyl having higher alkoxy, naphthyl having lower alkoxy, naphthyl having higher alkoxy, phenyl having lower alkyl, phenyl having higher alkyl, naphthoyl having higher alkoxy, phenyl εubεtituted with phenyl having lower alkyl, and oxo. ompound of claim 1, wherein lε ar (lower) alkenoyl εubstituteo with aryl which may have 1 to 3 substituent (s) selected from the group consiεting of lower alkoxy, higher alkoxy, lower alkyl, higher alkyl, higher alkoxy(lower) alkyl, phenyl having lower alkoxy, phenyl having higher alkoxy, naphthyl having lower alkoxy, naphthyl having higher alkoxy, phenyl having lower alkyl, phenyl having higher alkyl, naphthoyl having higher alkoxy, phenyl substituted with phenyl having lower alkyl, lower alkoxy (lower) alkyl, halo (lower) alkoxy, lower alkenyloxy, halo (higher) alkoxy, lower alkoxy (higher) alkoxy, and oxo; naphthyl (lower) alkenoyl which may have 1 to 3 higher alkoxy; lower alkynoyl which may have 1 to 3 εubεtituent (s) selected from the group consist of lower alkoxy, higher --I oxy, lower Ikyl, higher alkyl, higher alkoxy(lower) alky_, phenyl having lower alkoxy, phenyl having higher alkoxy, naphthyl having lower alkoxy, naphth l having higher alkoxy, phenyl having lower a_kyl, phenyl having higher alkyl, naphthoyl having higher alkoxy, phenyl substituted with phenyl having lower alkyl, and oxo; ar (C2 _ Cg) alkanoyl substituted with aryl having I to 3 εubεtituent (s) εelected from the group consiεting of lower alkoxy, higher alkoxy, lower alkyl, higher alkyl, higher alkoxy(lower) alkyl, phenyl having lower alkoxy, phenyl having higher alkoxy, naphthyl having lower alkoxy, naphthyl having higher alkoxy, phenyl having lower alkyl, phenyl having higher alkyl, naphthoyl having higher alkoxy, phenyl subεtituted with phenyl having lower alkyl, phenyl having lower alkoxy(lower) alkoxy, and oxo, in which ar(C 2 -Cg)- alkanoyl may have hydroxy, cxo, protected amino or amino; or (C2~Cg)alkanoyl εubεtituted with naphthyl having higher alkoxy. 4. A compound of claim 1, wherein R * iε aroyl substituted with heterocyclic group which may have 1 to 3 substituent (s) selected from the group consisting of lower alkoxy, higher alkoxy, lower alkyl, higher alkyl, higher alkoxy(lower)alkyl, phenyl having lower alkoxy, phenyl having higher alkoxy, naphthyl having lower alkoxy, naphthyl having higher alkoxy, phenyl having lower alkyl, phenyl having higher alkyl, naphthoyl having higher alkoxy, phenyl substituted with phenyl having lower alkyl, phenyl having lower alkoxy(higher) alkoxy, phenyl having higher alkenyloxy, heterocyclic group substituted with phenyl having lower alkoxy, heterocyclic group, cyclo(lower)alkyl having phenyl, phenyl having cyclo (lower)alkyl, phenyl substituted with heterocyclic group having lower alkyl and oxo, cyclo(lower) alkyl having lower alkyl, phenyl εubstituted with phenyl having lower alkoxy, phenyl havin: heterocyclic group and oxc, in which a:~yl may have halogen; aroyl εubεtituted with aryl having heterocyclic(higher)alkoxy, in which hete ocyclic group may have lower alkyl; aroyl εubεtituted with aryl having lower alkoxy(higher) alkoxy; aroyl substituted with aryl having lower a. -enyl (lower) alkoxy; aroyl substituted with 2 lower alkoxy; aroyl substituted with aryl having lower alkyl; or aroyl substituted with aryl having higher alkyl. 5. A compound of claim 1, wherein R 1 is aryloxy(lower)alkanoyl which may have 1 to 3 substituent (s) selected from the group consiεting of lower alkoxy, higher alkoxy, lower alkyl, higher alkyl, higher alkoxy(lower)alkyl, phenyl having lower alkoxy, phenyl having higher alkoxy, naphthyl having lower alkoxy, naphthyl having higher alkoxy, phenyl having lower alkyl, phenyl having higher alkyl, naphthoyl having higher alkoxy, phenyl substituted with phenyl having lower alkyl, and oxo; ar(lower)alkoxy(lower)alkanoyl which may have 1 tc 3 substituent(s) selected from the group co -sting of ower alkoxy, . 'her alkoxy, lower alkyl, higher lkyl, higher ε. .oxy(lower)alkyl, phenyl having lower alkoxy, phenyl having higher alkoxy, naphthyl having lower alkoxy, naphthyl having higher alkoxy, phenyl having lower alkyl, phenyl having higher alkyl, naphthoyl having higher alkoxy, phenyl substituted with phenyl having lower alkyl, and oxo; or arylamino (lower) alkanoyl which may have 1 to 3 substituent (ε) εelected from the group conεiεting of lower alkoxy, higher alkoxy, lower alkyl, higher alkyl, higher alkoxy (lower) alkyl, phenyl having lower alkoxy, phenyl having higher alkoxy, naphthyl having lower alkoxy, naphthyl having higher alkoxy, phenyl having lower alkyl, phenyl having higher alkyl, naphthoyl having higher alkoxy, phenyl εubεtituted with phenyl having lower alkyl, and oxo. 6. A compound cf claim 1, wherein ' R 1 is lower alkanoyl subεtituted with pyrazolyl which haε lower alkyl and aryl having higher alkoxy; lower alkoxy(higher) alkanoyl, in which higher alkanoyl may have amino or protected amino; aroyl substituted with aryl having heterocyclicoxy, in which heterocyclicoxy may have phenyl; aroyl substituted with cyclo (lower) alkyl having lower alkyl; indolylcarbonyl having higher alkyl; naphthoyl having lower alkyl; naphthoyl having higher alkyl; naphthoyl having lower alkoxy(higher) alkoxy; aroyl substituted with aryl having lower alkoxy(lower) lkoxy(higher) alkoxy; aroyl substituted with aryl having lower alkoxy(lower) alkoxy; aroyl substituted with aryl which has phenyl having lower alkoxy; aroyl substituted with aryl which has phenyl having lower alkoxy(lower) alkoxy; aroyl substituted with aryl having 210 - 259 - heterocyclicoxy(higher) al oxy; arcyϊ subεtituted w th aryl having phenoxy(lower)alkoxy; aroyl substituted with aryl naving heterocycliccarbonyl (higher)alkoxy; lower alkanoyl substituted with oxazolyl which has aryl having higher alkoxy; lower alkanoyl substituted w tr. furyl which has aryl subεtituted with phenyl having lower alkoxy; lower alkanoyl εubstituted with triazolyl which has oxo and rr.enyl having Higher alkyl; higher alkanoyl having hydroxy; higher aik' "oyl havir. T benzyl and hydroxy; 3-methyl-" _ecenoyl; or (C2-Cg)al.< .oyl sue."ituted w th aryl having higher alkoxy, in which ^-C )alkanoyl may have amino or pre- - "ted amino. 7. A compound of ela 1, wh R- is lower alkan subs ed w h : ,τ ridyl or pyridazinyl, h of h m-? na 1 to 3 substituent( select " ro t. rι e tp consiεting of higher al "xy, higne aiko (lc er)alkyl, phenyl havi higher alkoxy, ..enyl substituted with phenyl -.aving lower alkoxy, piperazinyl substituted with phenyl having higher alkoxy, piperazinyl substituted with phenyl having lower alkoxy(higher)alkoxy, and piperazinyl substituted with phenyl having lower alkoxy; lower alkanoyl substituted with 1,2,3,4- tetrahydroisoquinoline having higher alkoxy and lower alkoxy carbonyl; lower alkanoyl substituted with coumarin which may have 1 to 3 substituent (s) selected from the group consisting of higher alkoxy, and oxo; 10 - 260 - lower alkanoyl substituted with benzcthiopnenyi whic may have 1 to 3 higher alkoxy; lower alkanoyl εubstituted with benzo -b] furanyl which may have 1 to 3 substituent (s) εelected from the group consisting cf higher alkoxy and lower alkyl; lower alkanoyl substituted witr. benzocxazclyl which may have 1 to 3 substituent (s) selected from the group consiεting cf higher alkyl, phenyl having lower alkoxy, phenyl εubεtituted with phenyl having lower alkyl, and pyridyl having higher alkoxy; lower alkanoyl εubstitutec with benzi idazoiyi which may have 1 to 3 εubεtituent (ε) εelected from the group consisting of higher alkyl, and phenyl having lower alkoxy; or lower alkanoyl substituted with piperidyl or piperazinyl, each of which may have 1 to 3 substituent (s) selected from the group consiεting of phenyl having higher alkoxy, and naphthoyl having higher alkoxy. 8. A compound of claim 3, wherein R- is phenyl (lower) alkenoyl substituted with phenyl which may have 1 to 3 substituent (ε) εelected from the group consisting of lower alkoxy, lower alkyl, higher alkyl, lower alkoxy (lower) alkyl, halo (lower) alkoxy, lower alkenyloxy, halo (higher) alkoxy, and lower alkoxy(higher) alkoxy; naphthyl (lower) alkenoyl which may have 1 to 3 higher alkoxy; lower alkynoyl which may have 1 to 3 substituent (s) selected from the group consiεting of naphthyl having higher alkoxy, and phenyl substituted with phenyl having 1 r alkyl; phenyl (C2~Cg) alkanoyl substitu"-d with phenyl which has 1 to 3 εubεtituent (s) selected from the group consisting of lower alkoxy, higher alkoxy, lower alkyl, higher alkyl, and phenyl having lower alkoxy(lower) alkyl, in which phenyl (C2-C ) alkanoyl may have hydroxy, oxo, protected amino or amino; or (C2 _ Cg)alkanoyl substituted with naphthyl having higher alkoxy. 9. A compound of claim 4, wherein R- is benzoyl substituted with saturated 6-membered heteromonocyclic group containing at least one nitrogen atom which may have 1 to ' 3 εubεtituent (s) selected from the group consisting of phenyl having lower alkoxy, phenyl having higher alkoxy, phenyl having lower alkyl, phenyl having lower alkoxy(higher)alkoxy, phenyl having higher alkenyloxy, piperidyl su b stituted with phenyl having lower alkoxy, piperidyl, cyclo (lower)alkyl having phenyl, phenyl having cyclo(lower)alkyl, and phenyl substituted with triazolyl having oxo and lower alkyl, in which benzoyl may have halogen; benzoyl substituted with unsaturated 5-membered heteromonocyclic group containing 1 to 2 oxygen atom(s) and 1 to 3 nitrogen atom(s) which may have 1 to 3 substituent (s) selected from the group consisting of higher alkyl, phenyl having lower alkoxy, phenyl having higher alkoxy, phenyl having lower alkoxy(higher)alkoxy, and phenyl substituted with phenyl having lower alkoxy; benzoyl substituted with 5 cr 6-membered heteromonoccyclic group containing 1 or 2 nitrogen atom(ε) which may have 1 to 3 εubεtituent (s) selected from the croup consisting cf higher alkyl and phenyl having lower alkoxy; benzoyl subεtituted with 5-membered heteromonocyclic group containing 1 to 2 nitrogen atom(s) and 1 to 2 sulfur atom(ε) which may have 1 to 3 substituent (s) selected from the group consiεting of phenyl having lower alkoxy, phenyl having higher alkoxy, cyclo (lower) alkyl having lower alkyl, phenyl εubεtituted with phenyl having lower alkoxy, phenyl having cyclo (lower) alkyl, phenyl having piperidine, and phenyl having lower alkoxy (higher) alkoxy; benzoyl substituted with phenyl having higher alkoxy subεtituted with unsaturated 3 to 8- membered heteromonocyclic group containing at least one nitrogen atom; benzoyl substituted with phenyl having higher alkoxy substituted with saturated 6-membered heteromonocyclic group containing 1 to 2 oxygen atom(s) and 1 to 3 nitrogen atom(ε) which may have lower alkyl; benzoyl substituted with phenyl having lower alkoxy(higher) alkoxy; benzoyl substituted with phenyl having lower alkenyl (lower) alkoxy; benzoyl εubstituted with 2 lower alkoxy; benzoyl substituted with phenyl having lower alkyl; or benzoyl substituted with phenyl having higher alkyl. 10. A compound of claim 5, wherein R 1 is phenyloxy(lower) alkanoyl which may have 1 to 3 higher alkoxy; phenyl (lower) alkoxy(lower)alkanoyl which may have 1 to 3 higher alkoxy; or phenylamino (lower) alkanoyl which may have 1 to 3 higher alkoxy. 11. A compound of claim 1, wherein R 1 is benzoyl subεtituted with piperazinyl which may have 1 to 3 εubεtituent (s) εelected from the group conεiεting of phenyl having lower alkoxy, phenyl having higher alkoxy, phenyl having lower alkyl, phenyl having lower alkoxy(higher)alkoxy, phenyl having high€ alkenyloxy, piperidyl substituted with phenyl iving lower alkoxy, cyclo (lower) alkyl having pheny " phenyl having cyclo(lower)alkyl, and phenyl su εtituted with triazolyl having oxo and lower alkyl, in which benzoyl may have halogen; benzoyl substituted with isoxazolyl which may have 1 to 3 substituent(s) selected from the group consisting of higher alkyl, phenyl having lower alkoxy, phenyl having higher alkox ohenyl having lower alkoxy(higher)alkoxy, and phe..yl substituted with phenyl having lower alkoxy; benzoyl substituted with phenyl having lower alkoxy(higher)alkoxy; benzoyl substituted with phenyl having lower alkyl; benzoyl substituted with phenyl having higher alky_; phenyl(lower)alkenoyl substituted with phenyl which may have 1 to 3 substituent(s) selected from the group consisting of lower alkoxy, lower alkyl, higher alkyl, lower alkoxy(lower)alkyl, halo(lower)alkoxy, lower alkenyloxy, halo(higher)alkoxy and lower alkoxy(higher)alkoxy; benzoyl εubstituted with thiadiazolyl which may have 1 to 3 εubεtituent (ε) εelected from the group conεiεting of phenyl having lower alkoxy, phenyl having higher alkoxy, cyclo (lower) alkyl having lower alkyl, phenyl εubεtituted with phenyl having lower alkoxy, phenyl having cyclo (lower) alkyl, phenyl having piperidyl, and phenyl having lower alkoxy (higher) alkoxy; or benzoyl εubεtituted with oxadiazolyl which may have 1 to 3 substituent (s) selected from the group consisting of phenyl having lower alkoxy, phenyl having higher alkoxy, phenyl having lower alkoxy (higher) alkoxy, higher alkyl and phenyl subεtituted with phenyl having lower alkoxy. 12. A compound of claim 11, wherein R 1 iε benzoyl substituted with phenyl having lower alkoxy(higher) alkoxy; or benzoyl substituted with phenyl having lower alkyl. 13. A compound of claim 11, wherein R 1 is benzoyl substituted with piperazinyl which may have phenyl having lower alkoxy; benzoyl substituted with isoxazolyl which may have phenyl having lower alkoxy; benzoyl substituted with thiadiazolyl which may have phenyl having lower alkoxy(higher) alkoxy; or benzoyl subεtituted with oxadiazolyl which may have phenyl having lower alkoxy. 14. A compound of claim 11, wherein R is phenyl (lower) alkenoyl substituted with phenyl which may have lower alkoxy. /11210 - 265 - 15. A process for the preparation of a polypeptide compound of the formula [I] : wherein R 1 is lower alkanoyl substituted with unsaturated 6-membered heteromonocyclic group containing at least one nitrogen atom which may have one or more suitable substituent (s) ; lower alkanoyl substituted with 1,2,3,4- tetrahydro-isoquinoline having higher alkoxy; lower alkanoyl substituted with unsaturated condensed heterocyclic group containing at least one oxygen atom which may have one or more suitable substituent (s) ; lower alkanoyl substituted with unsaturated condensed he .rocyclic group contain. g 1 to 3 sulfur atom(s) which may have one or ore suitable substituent (s) ; lower alkanoyl substituted with unsaturated condensed heterocyclic group containing 2 or more nitrogen atom(s) which may have one or more suitable substituent(s) ; lower alkanoyl substituted with saturated 3 to 5-membered heteromonocyclic group containing at leaεt one nitrogen atom which may have one or more εuitable substituent (s) ; ar (lower) alkenoyl subεtituted with aryl which may have one or more εuitable εubεtituent (s) ; naphthyl (lower) alkencyi whicn may have one or more higher alkoxy; lower alkynoyl which may have one cr more εuitable substituent (ε) ; (C 2 ~Cg) alkanoyl substituted with naphthyl having higher alkoxy; ar (C2~C ) alkanoyl subεtituted with aryl having one or mere εuitable εubstituent (s) , in which ar (C 2 _ Cg) alkanoyl may have one or more suitable subεtituent (ε) ; aroyl substituted with heterocyclic group which may have one or more suitable substituent (s) , in which aroyl may have one or more suitable substituent (s) ; aroyl substituted with aryl having heterocyclic (higher) alkoxy, in which heterocyclic group may have one or more suitable substituent (s) ; aroyl substituted with aryl having lower alkoxy(higher) alkoxy; aroyl substituted with aryl having lower alkenyl (lower) alkoxy; aroyl substituted with 2 lower alkoxy; aroyl substituted with aryl having lower alkyl; aroyl substituted with aryl having higher alkyl; aryloxy(lower) alkanoyl which may have one or more suitable substituent (s) ; ar (lower) alkoxy(lower) alkanoyl which may have one or more suitable substituent (s) ; 95/01983 - 2 67 - arylamino (lower) alkanoyl which may have one or more εuitable subεtituent (s) ; lower alkanoyl substituted with pyrazolyl which has lower alkyl and aryl having higher alkoxy; lower alkoxy(higher) alkanoyl, in which higher alkanoyl may have one or more suitable substituent (s) ; aroyl εubεtituted with aryl having heterocyclicoxy, in which heterocyclicoxy may have one or more εuitable substituent (ε) ; aroyl εubεtituted with cyclo (lower) alkyl having lower alkyl; indolylcarbonyl having higher alkyl; naphthoyl having lower alkyl; naphthoyl having higher alkyl; naphthoyl having lower alkoxy (higher) alkoxy; aroyl substituted with aryl having lower alkoxy(lower) alkoxy(higher) alkoxy; aroyl substituted with aryl having lower alkoxy (lower) alkoxy; aroyl s_ostituted with aryl which has aryl having lower alkoxy; aroyl substituted with aryl which has aryl having lower alkoxy(lower) alkoxy; aroyl substituted with aryl having heterocyclicoxy(higher) alkoxy; aroyl substituted with aryl having aryloxy (lower) alkoxy; aroyl sui tituted with aryl having heterocycl; arbonyl (higher) alk- -y; lower alkanoyl substituted with oxazolyl which has aryl having higher alkoxy; lower alkanoyl substituted with furyl which has aryl substituted with aryl having lower alkoxy; lower alkanoyl substituted with triazolyl which has oxo and aryl having higher alkyl; higher alkanoyl having hydroxy; higher alkanoyl having ar (lower) alkyl and hydroxy; 3-methyl-tridecenoyi; or (C2~C )alkanoyl substituted w th aryl having higher alkoxy, in which (C--Cg) alkanoyl may have amino or protected amine, and a pharmaceutically acceptable salt thereof, which comprises reacting a compound of the formula or its reactive derivative at the amino group or a salt thereof, with a compound cf the formula : .1 _ OH II ' wherein R- is defined above, or its reactive derivative at the carboxy group or a salt thereof, to give a compound [I] of the formula : wherein R 1 is defined above, or a salt thereof. 16. A pharmaceutical composition which comprises, as an active ingredient, a compound of claim 1 or a pharmaceutically acceptable salt thereof in admixture with pharmaceutically acceptable carriers or excipients. 17. Use of a compound of claim 1 or a pharmaceutically acceptable salt thereof as a medicament. 18. A compound of claim 1 or a pharmaceutically acceptable salt thereof for use as a medicament. 19. A method for the prophylactic and/or the therapeutic treatment of infectious diseases caused by pathogenic microorganisms which comprises administering a compound of claim 1 or a pharmaceutically acceptable salt thereof to a human being or an animal.

Inventors: OHKI HIDENORI, TAKASUGI HISASHI, TOMISHIMA MASAKI, YAMADA AKIRA, OHKI, HIDENORI, TAKASUGI, HISASHI, TOMISHIMA, MASAKI, YAMADA, AKIRA
Applicants: FUJISAWA PHARMACEUTICAL CO, OHKI HIDENORI, TAKASUGI HISASHI, TOMISHIMA MASAKI, YAMADA AKIRA, FUJISAWA PHARMACEUTICAL CO., LTD., OHKI, HIDENORI, TAKASUGI, HISASHI, TOMISHIMA, MASAKI, YAMADA, AKIRA
Application year: 1995
Main classification: C07K7
IPC codes: A61K31, A61K38, A61P31, C07D487, C07K1, C07K7