PROPENOIC ESTER DERIVATIVES HAVING 4-HYDROXYPYRAZOLE GROUP AND THE USE

Abstract: The present invention relates to novel propenoic ester derivatives having 4-hydroxypyrazole group of formula (I) which have active fungicidal properties, wherein R<1> represents hydrogen, halogen, nitro, an alkyl group having 1 to 6 carbon atoms, or an alkoxy group having 1 to 6 carbon atoms; R<2> represents an alkoxy group having 1 to 6 carbon atoms, a haloalkoxy group having 1 to 6 carbon atoms, or an alkylthio group having 1 to 6 carbon atoms; R<3> represents an alkyl group having 1 to 6 carbon atoms, an allyl group, a benzyl group, a phenyl group, or a substituted phenyl group by substituent selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, nitro and halogen; R<4> represents hydrogen, halogen, an alkyl group having 1 to 6 carbon atoms, a phenyl group, or a substituted phenyl group by substituent selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, nitro and halogen; R<5> represents hydrogen, halogen, a haloalkyl group, an alkyl group having 1 to 6 carbon atoms, a phenyl group, or a substituted phenyl group by substituent selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, nitro and halogen; and X represents carbon or nitrogen.

Description: PROPENOIC ESTER DERIVATIVES HAVING 4-HYDROXYPYRAZOLE GROUP AND THE USE BACKGROUND OF THE INVENTION Technical Field The present invention relates to novel propenoic ester derivatives having 4- hydroxypyrazole group of the following formula (I) which have active fungicidal properties . wherein, R 1 represents hydrogen, halogen, nitro, an alkyl group having 1 to 6 carbon atoms, or an alkoxy group having 1 to 6 carbon atoms; R ~ represents an alkoxy group having 1 to 6 carbon atoms, a haloalkoxy group having 1 to 6 carbon atoms, or an alkylthio group having 1 to 6 carbon atoms; R 3 represents an alkyl group having 1 to 6 carbon atoms, an allyl group, a benzyl group, a phenyl group, or a substituted phenyl group by substituent selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, nitro and halogen; R 4 represents hydrogen, halogen, an alkyl group having 1 to 6 carbon atoms, a phenyl group, or a substituted phenyl group by substituent selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, nitro and halogen; R 5 represents hydrogen, halogen, a haloalkyl group, an alkyl group having 1 to 6 carbon atoms, a phenyl grou p, or a substituted phenyl group by substituent selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, nitro and halogen; and X represents carbon or nitrogen. DESCRIPTION OF THE PRIOR ART Even though the known fungicides possess excellent fungicidal properties the development of compounds based upon similar basic structure has given rise to the problem of resistance development by the target fungi due to long exposure to these compounds with common basic structure. As a result of continuous effort to solve this problem a series of novel propenoic ester derivative was disclosed firstly in European Patent No. 472300 of ICI Co., U.S.Patent No. 4994495, European Patent No. 422597 of BASF Co., U.S.Patent No. 5003101 and European Patent No. 460575 of Ciba-Geigy Co., but fungicidal activity of the reported compounds was too low and limited in its application therefore, there is a need for potent fungicides which possess effective fungicidal activity, low toxicity and good economy. Therefore, in consideration of the aforesaid points the present inventors have made efforts to develope new fungicidal compounds which have powerful fungicidal activities to various target fungi and low toxicity, we have applied for a patent about propenoic ester derivatives having pyrazole group and the use (Korean laid-opend patent No. 94-432, PCT/KR93/00052). As the result, the inventors of the present invention synthesized novel propenoic ester derivatives by using 4-hydroxypyrazole compound which have not been so far known. SUMMARY OF THE INVENTION The objective of the present invention is to provide novel propenoic ester derivatives with strong fungicidal activities toward various fungi and broad fungicidal spectrum and a simple manufacturing process. Another objective is to provide fungicidal compositions containing said derivatives as an active compound. DETAILED DESCRIPTION OF THE INVENTION The present invention is identified as propenoic ester derivatives having 4- hydroxypyrazole group which correspond to the following formula(I), and agricultural preparations containing compounds of formula(I) as an active ingredient Wherein, R > ' , t R>2 , r R>3 , τ R4 , n RS and X are respectively defined as the above. The present invention is identified as propenoic ester derivatives having 4- hydroxypyrazole group which correspond to die above formula(I), and agricultural preparations containing compounds of formula(I) as an active ingredient In the formula(I) according to the present invention the preferred derivatives with greatest fungicidal activities are where R 1 and R 4 represent hydrogen, R 2 represents methyl or methylthio group, R 3 represents phenyl or substituted a phenyl group by substituent selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, and R 5 represents trifluoromethyl or methyl group. According to d e present invention, propenoic ester derivatives of the above formula(I) can be prepared by the following two methods. As shown in the following reaction pathway 1, the first method is the preparation of propenoic ester derivatives of the above formula(I) by reacting the propenoic benzyl bromide of following formula(II) with 4-hydroxypyrazole of following l ιτnula(III) in the presence of an appropriate base. [Reaction Pathway 1] (ID (HI) (I) In the above formula(II) and (III), R',R 2 ,R 3 ,R 4 ,R 5 , and X are respectively defined as the above. In die above reaction, the compounds of formula(II) are reacted witi the same mole of the compound of formula(III) in the presence of 1-3 equivalence of base. Additionally in the above reaction, organic solvent such as chlorobenzene, tetrahydrofuran, dimethyl formamide or dichloroethane and base such as potassium carbonate, sodium hydride, triethylamine or pyridine may be used. The completion of reaction for obtaining die compound of formula(I) is when no more me compound of formula(II) is remained, and it can be easily checked by T.L.C. The compounds of formula(II) and formula(iπ) in the above reaction patiiway can be easily prepared by the well known reaction pathway that formylation, alkylation and bromination using substituted otolylacetic acid as starting material [Reference: The compound of formula(II); 1. K. Yamada, M. Kato and Y. Hirata, Tetrahedron Lett., 2745(1973). 2. G. N. Vyas and N. M. Shah, Org. Syπ., Coll. Vol., 4, 836(1963). 3. S. K. Dubey and S. Kumar, J. Org. Chem., 51, 3407(1986). The compound of formula (III) ; 1. S. Iwata, J. Namekata, K. Tanaka and K. Mitsuhashi, J. Het. Chem., 28, 1971(1991). 2. P. J. Fagan, E. E. Neidert, M. J. Nye, M. J. Ohare and W. Tang, Can. J. Chem., 57, 904(1979)]. As shown in die following reaction pathway 2, die second metiiod is the preparation of propenoic ester derivatives of the above formula (I) by reacting the glyoxylate derivatives of following formula (IV) witii alkoxymethyl triphenyl phosphine, alkylthiomethyl triphenyl phosphine or alkoxylamine, respectively. [Reaction Pad way 2.] (IV) (D Wherein, R',R 2 ,R\R 4 ,R\ and X are respectively defined as the above. In the above reaction, alkoxymethyl triphenyl phosphine, alkylthiomethyl triphenyl phosphine or alkoxylamine is reacted with the 1 -5 equivalence of the compound of formula (IV). In case of the reaction of alkoxy methyl triphenyl phosphine or alkylthiomethyl triphenylphosphine, tetrahydrofuran or diediyl ether can be used as an organic solvent. In case of die reaction of alkoxylamine, dichloromethane, 1,2-dichloroethane, ethyl alcohol or pyridine are desirable to be used as an organic solvent. The completion of reaction is realized when the compound of formula(IV) remains no more in the reaction and it can be easily checked by T.L.C.. The compound of formula(IV) in above reaction can be easily prepared by d e well known reaction pathway, diat is, oxalation, bromination and pyrazole condensation using 2-bromotoluene as starting material [Reference: 1. M. Ranbaud, M. Bakasse, C. T. Duguay and J. Villieras, Synthesis, 564(1988). 2. S. K. Dubey and S. Kumar, /. Org. Chem., 51, 3407(1986)]. The compound of the above foιτnula(I) which is prepared by above reaction pathway 1. and 2. consist of cis or trans stereoisomers according to the steric position of R 2 about double bond. cis - (I) trans - (I) o In die preparation o f the compound of above formula(I), th e reaction pathway 1. gave selectively tra/7.s-(I)compound . But the reaction pathway 2. gave mixture of trans- l) compound as major product and cis- (I) compound as minor product. The fungicidal activities of die compound® according to the present invention were tested for mixture of isomers as well as individual isolated isomer when isolation 5 was possible. New propenoic ester derivatives of formula (I) are typically listed in the following Table 1. 0 Table 1 Comp. No. R 1 R 2 R 3 4 R 5 X 17 H CH 3 O C3H 5 H Cl CH 18 H CH 3 O C 6 H 5 H C 2 H 5 CH 19 H CH 3 O C 6 H 5 H C 6 H 5 CH 20 H CH 3 O Q5H 5 Cl CF 3 CH 21 H CH 3 O H5 F CF 3 CH 22 H CH 3 O C 6 H 5 CH 3 CF 3 CH 23 H CH 3 O C 6 H 5 CH 3 CF 3 N 24 H CH 3 O C 6 H 5 C 2 H 5 CF 3 CH 25 H CH 3 O H 5 i-C 3 H 7 CF 3 CH 27 H CH 3 O CH 3 -^^— H CF 3 CH 37 H CH 3 O NO 2 — (T — H CF 3 N 38 H CH 3 O NOz- 7 ^^— H CH 3 CH 39 H CH 3 O Cl— J— H CF 3 CH 40 H CH 3 O C1— ) — H CF 3 N 50 H CH3O <r\ H CH 3 CH 5 1 H CH 3 O ^ ~CH2~ H CF3 CH 54 H CH 3 S Q.H 5 H CF 3 trans-CH 55 H CH 3 S H 5 H CH 3 CH 7 H CH 3 S H CH 3 CH Comp. No. R 1 R 2 R 3 R 4 R 5 X 73 H CHF 2 O QH, 74 4-C1 CF 3 CH 2 O H 5 75 4-C1 CH 3 O C 6 H 5 76 4-C1 CH 3 O C fi H 5 77 4-C1 CH 3 O H, 78 4-C1 CH 3 O CH, 79 4-C1 CH,S QH, 80 3-C1 CH 3 O C ή H 5 81 3-C1 CH 3 O C 6 H 5 82 3-C1 CH 3 O C Λ H 5 83 3-C1 CH 3 O CH 3 84 3,4-Cl 2 CH 3 O C 6 H 5 85 4-CH 3 CH 3 O H 5 86 4-CH 3 CH 3 O H 5 87 4-CH 3 CH 3 O C ή H 5 88 4-CH 3 CH 3 O CH 3 Comp. No. R 1 R 2 R 3 R 4 R 5 X 89 4-CH 3 O CH 3 O QH 5 H CF 3 CH 90 4-CH 3 O CH 3 O QH 5 H CF 3 N 91 4-CH 3 O CH 3 O C 6 H 5 H CH 3 CH 92 4-CH 3 O CH 3 O CH 3 H CF 3 CH 93 4-QH, CH 3 O QH, H CF 3 CH 94 4-QH, CH 3 O QH, H CF 3 N 95 4-NO 2 CH 3 O QH, H CF 3 CH 96 4-NO 2 CH 3 O QH, H CF 3 N 97 4-NO 2 CH 3 O QH, H CH 3 CH 98 4-NO 2 CH 3 O CH 3 H CF 3 CH The following examples more fully illustrate the present invention, but the invention is not intended to be limited thereby. EXAMPLE 1. trans-Meth yl-2- [2-(l -meth yl-3- trill uorom etiiyl -4-py razoy l)-methyl- pheny l]-3 - methoxy propenoate (Comp. No. 1) To a solution of medιyl-2-(2-bromomethylphenyl)-3-metiιoxypropenoate (511mg, 1.8mmol) in dimethylformamide (6ml) at room temperature was added 1 - methyl-3-trifluorornedιyl-4-hydroxypyrazole (300mg, 1.8mmol) and potassium carbonate (345mg. 2.5mmol). After being stirred for 15h at room temperature, the reaction mixture was quenched by addition of diethyl etiier (15ml) and water (20ml). The aqueous layer was extracted with dieihyl eihei . The com limed organic exuacts were washed with water (10ml x 3), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford crude product. Final purification was effected by silica-gel column chromatography (ethyl acetate/hexane, 2/1) to afford die Comp. NO. 1 (271mg, 51% yield). Η NMR (CDC1 3 ) : δ 3.65(s, 3H), 3.68(s, 3H), 3.74(s, 3H), 4.83(s, 2H), 6,88(s, 1H), 7.09~7.48(m, 4H), 7.54(s, 1H). m/e : 371(M + ) EXAMPLE 2. t/a "-Methyl-2-[2-(l-phenyl-3-trifluoromedιyl-4-pyrazoyl)-methyl-phenyl]-3- methoxy propenoate (Comp. No. 8) To a solution of methyl-2-(2-bromomethylphenyl)-3-methoxypropenoate (397mg, 1.4mmol) in dimediylformamide (5ml) at room temperature was added 1- phenyl-3-trifluoromethyl-4-hydroxypyrazole (320mg, 1.4mmol) and potassium carbonate (276mg, 2.0mmol). After being stirred for 15h at room temperature, the reaction mixture was quenched by addition of diethyl ether (15ml) and water (20ml). The aqueous layer was extracted with diediyl ether. The combined organic extracts were washed widi water (lϋml x 3), dried over anhydrous magnesium sulfate, filtered and concenuated under reduced pressure to afford cmde product. Final purification was effected by silica-gel column chromatography (ediyl acetate/hexane, 1/3) to afford the Comp. NO. 8. (460mg, 77% yield). Η NMR (CDC1 3 ) : δ 3.68(s, 3H), 3.77(s, 3H), 4.96(s, 2H), 7.15-7.62(m, 9H), 7.61 (s, 1H). m/e : 433(M + ) EXAMPLE 3 Ci ' s-Methy l-2-[2 -( l -ph enyl-3 -trifl uoromethyl-4-pyrazoyl)-methyl- phenyl]glyoxylate methyloxime (Comp. No. 10) rra;7.s--Methyl-2-[2-( l-phenyl-3-trifluoromethyl-4-pyrazoyl)-methyl- phenyl]glyoxylaιe methyloxime (Comp. No. 1 1). To a solution of mthyl-2-[2-(l-plιenyl-3-trilluoromethyl-4-pyrazoyl)-3-methyl- phenyl] glyoxylate (230mg. 0.6mmol) in methanol (5ml) at room termerature was added methoxy lamine hydrochloride (200mg, 2.5mmol) and pyridine (243 (A , 3mmol) and men heated to 70"C. After being stirred for 12h at 70"C, the reaction mixture was concentrated under reduced pressure, diluted with dichloromethane (15ml) and water (10ml). The aqueous layer was extracted with dichloromethane. The combined organic extracts were washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford crude product. Final purification was effected by silica-gel column chromatography (ediyl acetate/hexane, 1/3) to afford the Comp. No. 10 (lOOmg, 38% yield) and Comp. No. 11 (HOmg, 43% yield). Comp. No. 10. l H NMR (CDC1 3 ) : δ 3.92(s, 3H), 4.07(s, 3H), 5.33(s, 2H), 7.15~7.99(m, 9H). m/e : 434(M + ) R, : 0.49(edιyl acetate/hexane, 1/3) Comp. No. 11. Η NMR (CDC1 3 ) : δ 3.89(s, 3H), 4.03(s, 3H), 4.98(s, 2H), 7.10~7.93(m, 9H). m/e : 434(M + ) R f : 0.37(ethyl acetate/hexane, 1/3) EXAMPLE 4. trans-Methyl-2-[2( 1 -phenyl-3-methyl-4-pyrazoyl)-methyl-phenyl]-3- methoxypropenoate (Comp. No. 14). To a solution of medιyl-2-(2-bromomedιylphenyl)-3-methoxypropenoate (420mg, 1.5mmol) in dimediylformamide (6ml) at room temperature was added 1- phenyl-3-methyl-4-hydroxypyrazole (270mg, 1.5mmol) and potassium carbonate (276mg. 2.0mmol). After being stirred for 24h at room temperature, the reaction mixture was quenched by addition of diethyl etiier (15ml) and water (20ml), TTie aqueous layer was extracted witii diethyl etiier. The combined organic extracts were washed with water (10ml x 3), dried over anhydrous magnesium sulfate, filtered and concenuated under reduced pressure to afford crude product. Final purification was effected by silica-gel column chromatography (ethyl acetate/hexane, 1/3) to afford the Comp. NO. 14. (17()mg, 31% yield). 'H NMR (CDC1 3 ) : δ 2.25(s, 3H), 3.83(s, 3H), 3.99(s, 3H), 5.20(s, 2H), 7.10-7.15 (m, 9H), 7.82(S, 1H). m e : 379(M + ) EXAMPLE 5. trans-Methy l-2-[2 -( 1 -phenyl- 3-trif luorom ethyl- 4-pyr azoyl) -methy 1-phen yl]-3 - methyldiio propenoate (Comp. No. 54). To a solution of mediylthiomethyltriphenylphosphonium chloride (358mg, lmmol) in tetrahydrofuran (5ml) at -78"C was added dropwise n-butyl litiiium (2.5M in n-hexane, 46()μl , 1. 15mmol). After being stirred for l h at -78"C, a solution of methyl-2-[2-( l-phenyl-3-trifluoiOmethyl-4-pyrazoyl)-methyl-phenyl]glyoxylate (45 Omg, lmmol) in tetrahydrofuran (3ml) was added dropwise over 10 minute at -78°C to the reaction mixture. After warming up to -10"C, die reaction was allowed to proceed for 5h at - 10" C, and then quenched b y addition of water (20ml). The aqueo us layer was extracted with diethyl ether (15ml x 3).The combined organic extracts were washed witii brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford crude product. Final purification was effected by silica-gel column chromatography (ethylacetate/hexane, 1/5) to afford die Comp. No. 54 (342mg, 67% yield). Η NMR (CDC1 3 ) : δ 2.41 (s, 3H), 3.75(s, 3H), 5.02(s, 2H), 7.15-7.90(m, 9H), 7.95 (s, 1H). m/e : 449(M + ) The present invention is directed to the fungicidal compositions comprising the fungicidal compound of die present invention as an active compound. Said fungicidal compositions can be formulated in various forms such as aqueous dispersions, emulsions, dusts, granules and so forth. These compositions are preferred to comprise one or more active compounds of die present invention witii one or more suitable adjuvan ts such as carriers and diluents which are chemically inert to die active compound. The exact concenuation of the active compound in a composition diereof with an adjuvant dierefor can vaiy; it is only necessary that d e active compounds be present in sufficient amounts so as to make it possible d e application of a fungicidally effective dosage. For example, in die case that die compositions are emulsions or aqueous dispersions, die amount of die active compound is preferred to range from 10 to 90% by weight And in the case of dust compositions, said amount is preferred to range from 0.1 to 30% by weight, also in die case of granule compositions, die amount is preferred to range from 1 to 30%) by weight. But the amount of die active compound in die compositions is somewhat variable according to die purposed use of the compositions. Preferred carriers which are employed in die compositions according to die present invention are liquid carriers which are selected from alcohols (i.e. monohydric alcohols like methanol, dihydric alcohols like ethylene glycol, and trihydric alcohols like glycerine, etc.), ketones(i.e. acetone, methylethylketone, etc), edιers(i.e. dioxane, tetrahydrofuran, cellosolve, etc.), aliphatic hydrocarbons(i.e. gasoline, kerossene, etc.), hydrocarbon halide s(i.e. chloroform, carbon tetrachloride, etc.), acid amides(i.e. dimediylformamide, etc.), esters(i.e. butyl acetate, ethyl acetate, glyceride, etc.), and nitriles (i.e. aectonitrile, etc.), and solid carriers which are selected from mineral compounds such as kaoline, clay, bentonite, acid clay, talc, diatomaceous earth, silica and sand, and vegetable powders such as arbor. Above referred liquid carriers can be used separately or in company with one or more other liquid carriers. The fungicidal composition of die present invention may include emulsifying agent, spreaders, dispersing agents or permeating agents. Also, die composition may include nonionic, anionic or cation ic surfactants, for example, fatty acid soda or polyoxyalkyl esters, alkyl sulfonates or polyethylene glycolethers. On die other hand , one of the compounds of d e present invention or compositions containing the same, can be advantageously employed in combination with one or more additional known pesticidal compounds which are active agricultural chemical. Such additional pesticidal compounds may be insecticides, herbicides, plant hormones and sterilizers, and if necessary, fertilizers. Composition 1 (Emulsion) Comp. No. 1 20%(by weight) xylene 75% polyoxyethylen glycoletiier 5% The foregoing components were mixed to form an emulsion composition. Composition 2 (Dusts) Comp. No. 8 5% (by weight) kaoline 94.6%; silicon (antifoaming agent) 0.3%' polyoxyediylene glycoletiier 0.1% The foregoing components were mixed to form a dust composition. Composition 3 (Aqueous dispersion) The foregoing components were mixed to form an aqueous dispersion composition. Composition 4 (Granules) Comp. No. 54 10%(by weight) sodium lignosulfonate 5% bentonite 85% The foregoing components were kneaded using with water and formed into a granule composition. The superior fungicidal activities of propenoic ester derivatives(I) according to d e present invention prepared by he above examples were tested to check protective effect against die barley powdery mildew, die wheat leat rust, the rice blast and rice sheath blight A 10% acetone solution containing the compound(I) was diluted using Tween-20 solution of 250 ppm strength(50() ppm in the case of rice). 500 ml of this chemical solution was sprayed to plants of equal height and allowed to stand at room temperature for 24 hours. After evaporation of spray solution and water, the test plants were inoculated with target fungi. The tests were carried out two times by the same method. In the case of a fungicidal rate of 100%, the concentration of the test chemicals was gradually reduced until the EQ, value, namely the concentration (ppm) which gives an fungicidal rate of 50%;, was determined. TEST 1 Fungicidal Test for Rice Blast (RCB) Pyήculaήa oryzae Cavara KJ301 as test rice blast fungus was selected and inoculated on rice polish agar medium(Rice polish 20g, Dextrose lOg, Agar 15g, Distilled water 1 / ) to incubate at 26"C for 2 weeks, and tiien scratched airial mycelia with Rubber PoUshman were irradiated witii near fluorescent Ught to form spore at 25~28"C for 48 hours. A suspension of conidia in water(10 6 spores/ml) was prepared and sprayed upon die 3-4 leaf stage of rice plants on the fotiage. After placing in dark dew chamber for 24 hours, die treated plants were then held in Ughted growth chamber(26± 2"C, 80%) for 5 days, and rated on die disease severity. The disease severity was examined against the percent disease area on the first leaf right under 3-4 leaf stage and compared to die standard rating diagram. TEST 2 Fungicidal Test for Rice Sheath BUght (RSB) Rhizυctonia solani AG-1 was incubated in wheat bran medium (1 I , bottie), and then the agar disc was inoculated in growth chamber(27 ± 1"C) for 7 days. Rice plans in die 2-3 leaf stage in 5cm pots were inoculated with the milled conidia. After incubating in dew chamber(28 ± 1"C), the disease severity was examined a ainst the percent disease area on the applied leaf of 2-3 leaf stage and compared to the standard rating diagram. TEST 3 Fungicidal Test for Wheat Leaf Rust (WLR) Test was made to succession culture of Puccinia recondita against the host plants. For the succession culture and die fungicidal effect test, wheats(cultivar; chokwang) were grown in poly vinyl pots(diameter ; 6.5cm) for 7 days, and dien spores of the first leaf stage were inoculated. After placing the treated wheat in dew chamber at 20 ϋ C for 1 day, the plants was held in growth chamber (20"C, 70% for 10 days, and then rated on the disease severity. The disease severity was examined as the percent disease area after inoculating the spores for 10 days. TEST4 Fungicidal Test for Barley Powdery Mildew(BPM) Tests were made to succession culture of Eysiph graminis &. sp. hordei. For the succession culture and the fungicidal effect tests, barley(Dongbori No. 1) was grown in poly vinyl pots(diameter ; 6.5cm) for 7 days, and then spores of the first leaf stage were inoculated. The treated barley was held in growtii chamber(22~24"C, 50%), and die disease severity was rated after 7 days inoculation. In the above Test 1 -4, those compound which produced an fungicidal rate of 100%) at 500ppm and, for comparison, commercial fungicidals (controls) were tested according to die mediod mentioned above, and die EC^, values were determined. The results are shown in Table 2. EC,,, value means the concentration(ppm) which a fungicidal rate of 50%. The fungic idal rate of the test chemicals was determined according to die following ; Percent of disease area in u-eatment Control value(%) = (l ) x 100 Percent of disease area in untreated contral Table 2. The fungicidal rate of the test chemicals (EC, (I , ppm) (Notes) RCB(Rice Blast), RSB(Rice Sheath BUght) WLR(Wheat Leaf Rust), BPM(Barley Powdery Mildew) A* : Propenoic ester compound disclosed in European Patent No. 472300. B** : Propenoic ester compound disclosed in European Patent No. 460575.

Claims: WHAT IS CLAIMED IS : 1. A compound of formula (I): wherein, R 1 represents hydrogen, halogen, nitro, an alkyl group having 1 to 6 carbon atoms, or an alkoxy group having 1 to 6 carbon atoms; R 2 represents an alkoxy group having 1 to 6 carbon atoms, a haloalkoxy group having 1 to 6 carbon atoms, or an alkylthio group having 1 to 6 carbon atoms; R 3 represents an alkyl group having 1 to 6 carbon atoms, an aUyl group, a benzyl group, a phenyl group, or a substituted phenyl group by substituent selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, nitro and halogen; R 4 represents hydrogen, halogen, an alkyl group having 1 to 6 carbon atoms, a phenyl group, or a substituted phenyl group by substituent selected from die group consisting of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, nitro and halogen; R 5 represents hydrogen, halogen, a haloalkyl group, an alkyl group having 1 to 6 carbon atoms, a phenyl group, or a substituted phenyl group by substituent selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, nitro and halogen; and X represents carbon or nitrogen. 2. A compound according to claim 1, wherein R 1 represents hydrogen or halogen. 3. A compound according to claim 1 to 2, wherein R 2 represents meti oxy or methylthio group. 4. A compound according to claim 1 to 3, wherein R 3 represents a phenyl group or a substituted phenyl group by substituent selected from the group consisting of halogen, methyl, methoxy and nitro. 5. A compound according to claim 1 to 4, wherein R 4 is hydrogen, halogen or methyl. 6. A compound according to claim 1 to 5, wherein R 5 represent hydrogen, trifluoromethyl or methyl. 7. A compound of formula (II), as an intermediate of formula (I) which have active fungicidal properties: (II) Wherein, R',R 2 and X are respectively defined as above claim 1. 8. A compound of formula (IV), as an intermediate of formula (I) which have active fungicidal properties. (IV) Wherein, R',R 2 ,R ,R ,R and X are respectively defined as above claim 1. 9. A fungicidal composition containing formula(I) as active compound Wherein, R ,R",R ,R ,R and X are respectively defined as above claim 1.

Inventors: HWANG KI-JUN, KIM BYUNG SUP, KIM SUNG SOO, HWANG, KI-JUN, KIM, BYUNG, SUP, KIM, SUNG, SOO
Applicants: HWANG KI JUN, KIM BYUNG SUP, KIM SUNG SOO, KOREA RES INST CHEM TECH, HWANG, KI-JUN, KIM, BYUNG, SUP, KIM, SUNG, SOO, KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Application year: 1995
Main classification: C07D239
IPC codes: A01N43, C07D231