SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION

Abstract: A class of substituted thiazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula (II), wherein R<4> is selected from alkyl and amino, wherein R<5> is selected from aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R<5> is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, aminosulfonyl, alkyl, alkenyl, alkynyl, cyano, carboxyl, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, acyl, N-alkylaminocarbonyl, N-arylaminocarbonyl, N,N-dialkylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, haloalkoxy, amino, N-alkylamino, N,N-dialkylamino, heterocyclic and nitro; and wherein R<6> is selected from halo, amino, alkoxy, nitro, hydroxyl, aminocarbonyl, acyl, alkylaminocarbonyl, arylaminocarbonyl, alkenyl, alkynyl, haloalkoxy, alkylamino, arylamino, aralkylamino, alkoxycarbonylalkyl, alkylaminoalkyl, heterocycloalkyl, aralkyl, cyanoalkyl, N-alkylsulfonylamino, heteroarylsulfonylalkyl, heteroarylsulfonylhaloalkyl, aryloxyalkyl, aralkyloxyalkyl, aryl and heterocyclo, wherein the aryl and heterocyclo radicals are optionally substituted at a substitutable position with one or more radicals selected from halo, alkyl, alkoxy, alkylthio, alkylsulfinyl, haloalkyl, haloalkoxy, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, amino, acyl and alkylamino; or a pharmaceutically-acceptable salt thereof.

Description: SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION FIELD OF THE INVENTION This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating inflammation and inflammation-associated disorders, such as arthritis. BACKGROUND OF THE INVENTION Prostaglandins play a major role in the inflammation process and the inhibition of prostaglandin production, especially production of PGG 2 , PGH 2 and PGE 2 , has been a common target of antiinflammatory drug discovery. However, common non-steroidal antiinflammatory drugs (NSAIDs) that are active in reducing the prostaglandin-induced pain and swelling associated with the inflammation process are also active in affecting other prostaglandin-regulated processes not associated with the inflammation process. Thus, use of high doses of most common NSAIDs can produce severe side effects, including life threatening ulcers, that limit their therapeutic potential. An alternative to NSAIDs is the use of corticosteroids, which have even more drastic side effects, especially when long term therapy is involved. Previous NSAIDs have been found to prevent the production of prostaglandins by inhibiting enzymes in the human arachidonic acid/prostaglandin pathway, including the enzyme cyclooxygenase (COX) . The recent discovery of an inducible enzyme associated with inflammation (named "cyclooxygenase-2 (COX-2)" or "prostaglandin G/H synthase II") provides a viable target of inhibition which more effectively reduces inflammation and produces fewer and less drastic side effects. The references below that disclose antiinflammatory activity, show continuing efforts to find a safe and effective antiinflammatory agent. The novel thiazoles disclosed herein are such safe and also effective antiinflammatory agents furthering such efforts. The invention compounds are found to show usefulness in vivo as antiinflammatory agents with minimal side effects. The substituted thiazoles disclosed herein preferably selectively inhibit cyclooxygenase-2 over cyclooxygenase-1. U.S. Patent No. 5,232,921 to Biziere et al . describes 2-alkylaminothiazoles as having an affinity for muscarinic cholinergic receptors. PCT application WO 93/15071, published Aug. 5, 1993, describes 4- (2-pyridyl) thiazole derivatives as inhibiting gastric acid secretion. Specifically, 2- (phenyImethyl) -4- (2-pyridyl) -5- (2-methylphenyl)thiazole is described. U.S. Patent No. 4,612,321 to S. Terao and Y. Ma i describes 5-pyridylthiazole derivatives, and specifically 5-pyridyl-4- (4-methoxyphenyl) -2- thienylthiazole, as having antiinflammatory activity. U.S. Patent No. 4,659,726 to Yoshino et al. , describes 4, 5-bis (4-methoxyphenyl) -2- (2- pyrrolyl) hiazoles as being effective as platelet aggregation inhibitors. U.S. Patent No. 5,217,971 to Takasugi et al. describes 4, 5-diphenylthiazole compounds as having antiinflammatory properties, and specifically 4, 5-bis (4-methoxyphenyl) -2- (4- pyridyl) thiazole. U.S. Patent No. 4,168,315 to R. Rynbrandt and E. Nishizawa describes 4, 5-diphenylthiazole derivatives as being blood platelet agglutination inhibitors. U.S. Patent No. 4,322,428 to K. Matsumoto and P. Ho, describe 2- (4-halophenyl) -4, 5-bis (4- methoxyphenyl) thiazoles as being antiinflammatory. U.S. Patent No. 4,451,471 to P. Ferrini and R. Gόschke describes 2-thio-4, 5,diarylthiazole derivatives as having antiinflammatory activity. 4,5-Bis(4- methoxyphenyl) thiazole is described as a synthetic intermediate. PCT application WO 87/6429, published Nov. 5, 1987, describes thienylthiazole compounds, and specifically 4- (4-chlorophenyl) -2- (5-chloro-2-thienyl) - 5- (4-methylphenyl) thiazole, as having insecticidal utility. U.S. Patent No. 4,051,250 to Dahm et al . describes 4, 5-diarylthiazole compounds as being antiinflammatory. Specifically, 2-chloro-4- (4-chlorophenyl) -5- (4- methylmercaptophenyl) hiazole is described as a synthetic intermediate. European Application EP 592,664, published April 20, 1994, describes 4,5- diphenylthiazoles as having antiinflammatory activity, and specifically 4- [4- (methylsulfonyloxy)phenyl] -5- phenyl-2- [bis(N-methylsulfonyl)amino]thiazole. Seko et al. [ Chem. Pharm. Bull . , 39, 651 (1991)] describe the platelet aggregation and cyclooxygenase inhibitory- activity of 4, 5-diphenylthiazoles, and specifically of 4, 5-bis (4-methylthiophenyl) -2- (1, 5-dimethyl-2- pyrrolyl)thiazole. Japanese application 4,244,073 describes thiazole compounds for the treatment of thrombosis. PCT application, WO 95/00501, published January 5, 1995, describes substituted thiazoles as antiinflammatories. Japanese application JP 4,173,782 describes 2-haloalkylsulfonamide-4, 5-diphenylthiazole derivatives as having antiinflammatory activity. U.S. Patent No. 4,632,930 to D. Carini and R. Wexler describes alkylaryl thiazole derivatives, and specifically 5-phenyl-4- (methylsulfonylphenyl) - α,α -bis (trifluoromethyl) thiazole-2-methanol, as having antihypertensive properties. DESCRIPTION OF THE INVENTION A class of substituted thiazolyl compounds useful in treating inflammation and inflammation-related disorders is defined by Formula I: wherein R 1 is selected from hydrido, halo, amino, alkoxy, cyano, nitro, hydroxyl, aminocarbonyl, acyl, alkylaminocarbonyl, arylaminocarbonyl, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, alkylamino, arylamino, aralkylamino, carboxyl, carboxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkylaminoalkyl, heterocycloalkyl, aralkyl, hydroxyalkyl, alkoxyalkyl, cyanoalkyl, N-alkylsulfonylamino, heteroarylsulfonylaikyl, heteroarylsulfonylhaloalkyl, aryloxyalkyl, aralkyloxyalkyl, aryl and heterocycio, where the aryl and heterocycio radicals are optionally substituted at a substitutable position -with one or more radicals selected from halo, alkyl, alkoxy, alkylthio, alkylsulfinyl, haloalkyl, haloalkoxy, carboxyalkyl-, alkoxycarbonyl, aminocarbonyl, amino, acyl and alkylamino; and wherein R 2 and R 3 are independently selected from alkyl, alkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R 2 and R 3 are optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, a inosulfonyl, alkyl, alkenyl, alkynyl, cyano, carboxyl, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, acyl, N-alkylaminocarbonyl, N-arylaminocarbonyl, N,N- dialkylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, haloalkyl, hydroxyl, alkoxy, alkoxyalkyl, hydroxyalkyl, haloalkoxy, amino, N-alkylamino, N,N- dialkylamino, heterocyclic and nitro; provided one of R 2 and R 3 is aryl substituted with alkylsulfonyl, haloalkylsulfonyl or aminosulfonyl; further provided that R 2 is not 4- fluorophenyl when R 1 is methyl and R 3 is 4- methylsulfonylphenyl; further provided that R 3 is not 4-fluorophenyl when R 1 is methyl and R 2 is 4- aminosulfonylphenyl; further provided R 2 and R 3 are not phenyl substituted with α,α-bis (methyl)methanol; and further provided that R 2 is not 4- (methylsulfonyl)phenyl when R 1 is α,α -bis (trifluoromethyl)methanol; or a pharmaceutically-acceptable salt thereof. The phrase "further provided", as used in the above description, is intended to mean that the denoted proviso is not to be considered conjunctive with the other provisos. Compounds of Formula I would be useful for, but not limited to, the treatment of inflammation in a subject, and for treatment of other inflammation- associated disorders, such as, as an analgesic in the treatment of pain and headaches, or as an antipyretic for the treatment of fever. For example, compounds of the invention would be useful to treat arthritis, including but not limited to rheumatoid arthritis, spondyloarthopathies, gouty arthritis, osteoarthritis, systemic lupus erythematosus and juvenile arthritis. Such compounds of the invention would be useful in the treatment of asthma, bronchitis, menstrual cramps, tendinitis, bursitis, and skin related conditions such as psoriasis, eczema, burns and dermatitis. Compounds of the invention also would be useful to treat gastrointestinal conditions such as inflammatory bowel disease, Crohn's disease, gastritis, irritable bowel syndrome and ulcerative colitis and for the prevention of colorectal cancer. Compounds of the invention would be useful in treating inflammation in such diseases as vascular diseases, migraine headaches, periarteritis nodosa, thyroiditis, aplastic anemia, Hodgkin's disease, sclerodoma, rheumatic fever, type I diabetes, myasthenia gravis, multiple sclerosis, sarcoidosis, nephrotic syndrome, Behcet 's syndrome, polymyositis, gingivitis, hypersensitivity, conjunctivitis, swelling occurring after injury, myocardial ischemia, and the like. The compounds were also be useful in the treatment of ophthalmic diseases such as retinitis, retinopathies, uveitis, and of acute injury to the eye tissue. The compounds would also be useful for the treatment of certain central nervous system disorders such as Alzheimer's disease and dementia. The compounds of the invention are useful as anti-inflammatory agents, such as for the treatment of arthritis, with the additional benefit of having significantly less harmful side effects. These compounds would also be useful in the treatment of allergic rhinitis, respiratory distress syndrome, endotoxin shock syndrome, atherosclerosis and central nervous system damage resulting from stroke, ischemia and trauma. Besides being useful for human treatment, these compounds are also useful for treatment of mammals, including horses, dogs, cats, rats, mice, sheep, pigs, etc. The present compounds may also be used in co- therapies, partially or completely, in place of other conventional antiinflammatories, such as together with steroids, NSAIDs, 5-lipoxygenase inhibitors, LTB 4 antagonists and LTA 4 hydrolase inhibitors. Suitable LTB 4 inhibitors include, among others, ebselen, Bayer Bay-x-1005, Ciba Geigy compound CGS- 25019C, Leo Denmark compound ETH-615, Lilly compound LY- 293111, Ono compound ONO-4057, Terumo compound TMK-688, Lilly compounds LY-213024, 264086 and 292728, ONO compound ONO-LB457, Searle compound SC-53228, calcitrol, Lilly compounds LY-210073, LY223982, LY233469, and LY255283, ONO compound ONO-LB-448, Searle compounds SC-41930, SC-50605 and SC-51146, and SK&F compound SKF-104493. Preferably, the LTB 4 inhibitors are selected from ebselen, Bayer Bay-x-1005, Ciba Geigy compound CGS-25019C, Leo Denmark compound ETH-615, Lilly compound LY-293111, Ono compound ONO-4057, and Terumo compound TMK-688. Suitable 5-LO inhibitors include, among others, masoprocol, tenidap, zileuton, pranlukast, tepoxalin, rilopirox, flezelastine hydrochloride, enazadrem phosphate, and bunaprolast. The present invention preferably includes compounds which selectively inhibit cyclooxygenase-2 over cyclooxygenase-1. Preferably, the compounds have a cyclooxygenase-2 IC 50 equal to or less than about 0.2 μM, and also have a selectivity ratio of cyclooxygenase-2 inhibition over cyclooxygenase-1 inhibition of at least 50, and more preferably of at least 100. Even more preferably, the compounds have a cyclooxygenase-1 IC 50 of greater than about 1.0 μM, and more preferably of greater than 10 μM. Such preferred selectivity may indicate an ability to reduce the incidence of common NSAID-induced side effects. A preferred class of compounds consists of those compounds of Formula I wherein R 1 is selected from hydrido, halo, amino, lower alkoxy, cyano, nitro, hydroxyl, aminocarbonyl, acyl, lower alkylaminocarbonyl, phenylaminocarbonyl, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, lower haloalkoxy, lower alkylamino, phenylamino, lower aralkylamino, carboxyl, lower carboxyalkyl, lower alkoxycarbonyl, lower alkoxycarbonylalkyl, lower alkylaminoalkyl, lower het'erocycloalkyl, lower aralkyl, lower cyanoalkyl, lower N-alkylsulfonylamino, lower heteroarylsulfonylaikyl, lower heteroarylsulfonylhaloalkyl, lower aryloxyalkyl, lower aralkyloxyalkyl, aryl and heterocycio, wherein the aryl and heterocycio radicals are optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower haloalkyl, lower haloalkoxy, lower carboxyalkyl, lower alkoxycarbonyl, aminocarbonyl, amino, acyl and lower alkylamino; and wherein R 2 and R 3 are independently selected from lower alkyl, lower alkenyl, aryl, lower cycloalkyl, lower cycloalkenyl and heterocyclic; wherein R 2 and R 3 are optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, lower alkenyl, lower alkynyl, cyano, carboxyl, lower carboxyalkyl, lower alkoxycarbonyl, aminocarbonyl, acyl, lower N- alkylaminocarbonyl, N-arylaminocarbonyl, lower N,N- dialkylaminocarbonyl, lower N-alkyl-N- arylaminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, amino, lower alkylamino, heterocyclic and nitro; or a pharmaceutically-acceptable salt thereof. A class of compounds of particular interest consists of those compounds of Formula I wherein R 1 is selected from fluoro, chloro, bromo, iodo, amino, methoxy, ethoxy, propoxy, butoxy, isopropoxy, tert- butoxy, cyano, nitro, hydroxy, aminocarbonyl, formyl, acetyl, N-methylaminocarbonyl, N-phenylaminocarbonyl, N,N-dimethylaminocarbonyl, N-methyl-N- phenylaminocarbonyl, methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, tert-butyl, ethylenyl, propylenyl, butenyl, ' pentenyl, isopropylenyl, isobutylenyl, propargyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, N-methylamino, N-ethylamino, N- propylamino, N-butylamino, N-tert-butylamino, N- pentylamino, N-hexylamino, N,N-dimethylamino, carboxyl, N-benzylamino, 3, 5-dichlorophenylamino, 3,5- dichlorophenoxymethyl, 3-chlorophenoxymethyl, carboxymethyl, methoxycarbonyImethyl, ethoxycarbonyImethyl, methylaminomethyl, morpholinomethyl, pyrrolidinyImethyl, piperazinylmethyl, piperidinyImethyl, pyridyImethyl, thienyImethyl, benzyl, phenethyl, phenylpropyl, cyanomethyl, phenoxymethyl, benzyloxymethyl, methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl, tert-butoxycarbonyl, propoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, pentoxycarbonyl, N- methylsulfonylamino, (2-thienyl) sulfonyImethyl, (2- thienyl) sulfonylbromomethyl, phenyl optionally substituted at a substitutable position with one or more radicals selected from fluoro, chloro, bromo, methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, tert-butyl, methoxy, ethoxy, propoxy, butoxy, isopropoxy, tert-butoxy, methylthio, methylsulfinyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, carboxymethyl, methoxycarbonyl, ethoxycarbonyl, aminocarbonyl, amino, formyl, ethylamino and dimethylamino, and heterocyclic selected from morpholino, pyrrolidinyl, piperazinyl, piperidinyl, pyridyl, thienyl, thiazolyl, oxazolyl, pyrimidinyl, pyrazinyl, quinolyl; isoquinolyl, imidazolyl, and benzimidazolyl, furyl, pyrrolyl, pyrazolyl and triazolyl, optionally substituted at a substitutable position with one or more radicals selected from fluoro, chloro, bromo, methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, fcert- butyl, methoxy, ethoxy, propoxy, butoxy, isopropoxy, tert-butoxy, methylthio, methylsulfinyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, carboxymethyl, methoxycarbonyl, ethoxycarbonyl, aminocarbonyl, amino, formyl, methylamino and dimethylamino; and wherein R 2 and R 3 are independently selected from methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, tert- butyl, ethylenyl, propylenyl, butenyl, pentenyl, isopropylenyl, isobutylenyl, phenyl, naphthyl, biphenyl, pyridyl, thienyl, thiazolyl, oxazolyl, pyrimidinyl, pyrazinyl, quinolyl, isoquinolinyl, imidazolyl, benzimidazolyl, furyl, pyrrolyl, pyrazolyl, triazolyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, morpholino, pyrrolidinyl, piperazinyl and piperidinyl; wherein R 2 and R 3 are optionally substituted at a substitutable position with one or more radicals selected from fluoro, chloro, bromo, methylthio, methylsulfinyl, methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, tert-butyl, ethylenyl, propylenyl, butenyl, pentenyl, isopropylenyl, isobutylenyl, propargyl, cyano, carboxyl, carboxymethyl, methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl, tert- butoxycarbonyl, propoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, pentoxycarbonyl, aminocarbonyl, formyl, acetyl, N-methylaminocarbonyl, N- phenylaminocarbonyl, N,N-dimethylaminocarbonyl, N- methyl-N-phenylaminocarbonyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, hydroxyl, methoxy, ethoxy, propoxy, butoxy, isopropoxy, tert-butoxy, hydroxymethyl, trifluoromethoxy, amino, N-methylamino, N,N-dimethylamino, pyridyl, furyl, pyrazinyl, pyrrolyl, pyrazolyl, morpholino, pyrrolidiny1, piperazinyl, piperidinyl, triazolyl and nitro; or a pharmaceutically-acceptable salt thereof. A family of specific compounds of particular interest within Formula I consists of compounds and pharmaceutically-acceptable salts thereof as follows : 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- phenylthiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (4- methoxyphenyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (4- chlorophenyl) thiazole; 5-[ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (N- hexylamino)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (N- methyla ino)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (N- ethylamino)thiazole; 5- [ (4-methylsulfonyl)phenyl]-4- (4-fluorophenyl) -2- (N- tert-butylamino)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (N- (4-phenoxypheny1)amino) thiazole; ethyl 4- [ [5- [ (4-methylsulfonyl)phenyl] -4- (4- fluorophenyl) -2-thiazolyl]amino]benzoate; ethyl 3- [ [5- [ (4-methylsulfonyl)phenyl] -4- (4- fluorophenyl) -2-thiazolyl]amino]benzoate; 5-[ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (2- phenylethyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (N- (3,5-dichlorophenyl)amino) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (N- butylamino) thiazole; 4- [5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- thiazolyl]aminobenzoic acid; 3- [5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- thiazolyl]aminobenzoic acid; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ethylthiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (3- phenylpropyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3- chlorophenoxy)methyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (2- methyl-4-thiazolyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (2-fluorophenyl) -2- (2- chlorophenyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (2, 5-difluorophenyl) -2- (2-chlorophenyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (2,3,4,5, 6-pentafluorophenyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (2- chlorophenoxy)methyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-bromophenyl) -2- (2- chlorophenyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (2-fluorophenyl) -2- ( (3- chlorophenoxy)methyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3, 5-dichlorophenoxy)methyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (2-fluorophenyl) -2- ( (4- methoxyphenoxy)methyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-bromophenyl) -2- (2- chlorophenyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-methylthiophenyl) -2- (2-chlorophenyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (3-fluoro-4- methoxyphenyl) -2- (2-chlorophenyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (3-chloro-4- methoxyphenyl) -2- (2-chlorophenyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (3-chloro-4- methylphenyl) -2- (2-chlorophenyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (3-methyl-4- chlorophenyl) -2- (2-chlorophenyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (3,4- methylenedioxyphenyl) -2- (2-chlorophenyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (3, 5-difluoro-4- methoxyphenyl) -2- (2-chlorophenyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (3, 5-dichloro-4- methoxyphenyl) -2- (2-chlorophenyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (difluoromethyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (methylthio)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (phenylthio)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3- fluorophenyl)thio)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3- chlorophenyl) thio) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3- bromophenyl)thio)thiazole; 5-[ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3, 5-difluorophenyl)thio) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- [ (3, 5-dichlorophenyl)thio] thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- [ (4- fluorophenyl)thio]thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- [ (4- chlorophenyl)thio]thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- [ (4- bromophenyl) thio] ' thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (4- methylpheny1) thio) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (benzylthio)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3- fluorobenzyl)thio)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3- chlorobenzy1)thio)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3- bromobenzyl) thio)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3, 5-difluorobenzyl)thio) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3, 5-dichlorobenzyl) thio) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (4- fluorobenzyl)thio)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (4- chlorobenzyl)thio)thiazole; 5-[ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (4- bromobenzyl) thio)thiazole; 5-[ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- { (4- methylbenzyl)thio)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (ethylsulfonyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (methylsulfonyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (phenylsulfonyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3- fluorophenyl) sulfonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3- chlorophenyl)sulfonyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3- bromophenyl) sulfonyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3, 5-difluorophenyl) sulfonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3, 5-dichlorophenyl)sulfonyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl -2-U4- fluorophenyl) sulfonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl -2-((4- chlorophenyl)sulfonyl)thiazole; 5-[ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl -2-U4- bromophenyl) sulfonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl -2-((4- methylphenyl)sulfonyl)thiazole; 5- [ (4-methylsulfonyl) henyl] -4- (4-fluorophenyl -2- (benzylsulfonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl -2-((3- fluorobenzyl) sulfonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl -2-((3- chlorobenzyl)sulfony1)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl -2-U3- bromobenzyl) sulfonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl -2- ( (3, 5-difluorobenzyl) sulfonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl -2- ( (3, 5-dichlorobenzyl)sulfonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl -2-((4- fluorobenzyl)sulfonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl -2-U4- chlorobenzyl) sulfonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl -2-U4- bromobenzyl) sulfonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl -2-{(4- methylbenzyl)sulfonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl -2- (fluoromethylsulfonyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl ■ 2- (acetyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl -2- (trifluoroacetyl)thiazole; 5-[ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl -2- (benzoyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (3- fluorobenzoyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (3- chlorobenzoyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (3- bromobenzoyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (3,5- difluorobenzoyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (3,5- dichlorobenzoyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (4- fluorobenzoyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (4- chlorobenzoyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (4- bromobenzoyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (4- methylbenzoyl)thiazole; methyl [5- [ (4-methylsulfonyl)phenyl] -4- (4- fluorophenyl) -2-thiazolyl] carboxylate; ethyl [5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) - 2-thiazolyl] carboxylate; propyl [5-[ (4-methylsulfonyl)phenyl] -4- (4- fluorophenyl) -2-thiazolyl]carboxylate; butyl [5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) - 2-thiazolyl] carboxylate; 5- t (4-methylsulfonyl) henyl] -4- (4-fluorophenyl) -2- (hydroxymethyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4-(4-fluorophenyl) -2- (methoxymethyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (phenoxymethyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (3- fluorophenoxymethyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (3- chlorophenoxymethyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (3- bromophenoxymethyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (3,5- difluorophenoxymethyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (3,5- dichlorophenoxymethyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (4- fluorophenoxymethyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (4- chlorophenoxymethyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (4- bromophenoxymethyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (4- methylphenoxymethyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (benzyloxymethyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (cyanomethyl) thiazole; 5- [ ( -methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (2- quinolylmethyloxymethyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (2- naphthylmethyloxymethyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (N- phenylaminocarbonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- [ (3- fluorophenyl)aminocarbonyl]thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- [ (3- chloropheny1)aminocarbonyl]thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2-[ (3- bromophenyl)aminocarbonyl] thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- [ (3, 5-difluorophenyl)aminocarbonyl]thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- [ (3, 5-dichlorophenyl)aminocarbonyl]thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- [ (4- fluorophenyl)aminocarbonyl]thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- [ (4- chloropheny1)aminocarbonyl] thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- [ (4- bromophenyl)aminocarbonyl] thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- [ (4- methylphenyl)aminocarbonyl]thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (benzylaminocarbonyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3- fluorobenzyl)aminocarbonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3- chlorobenzyl)aminocarbonyl)thiazole; 5- [ (4-methylsulfonyl) henyl] -4- (4-fluorophenyl) -2- ( (3- bromobenzyl)aminocarbonyl) thiazole; 5- [ (4-methylsulfonyl) henyl] -4- (4-fluorophenyl) -2- ( (3, 5-difluorobenzyl)aminocarbonyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3, 5-dichlorobenzyl)aminocarbonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (4- fluorobenzyl)aminocarbonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (4- chlorobenzyl)aminocarbonyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (4- bromobenzyl)aminocarbonyl) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (4- methylbenzyl)aminocarbonyl)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (benzoylamino) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3- fluorobenzoyl)amino)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3- chlorobenzoyl) mino)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3- bromobenzoyl)amino)thiazole; 5-[ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3, 5-difluorobenzoyl)amino)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (3, 5-dichlorobenzoyl)amino)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (4- fluorobenzoyl)amino)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (4- chlorobenzoylamino)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (4- bromobenzoyl)amino)thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- ( (4- methylbenzoyl)amino) thiazole; 5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- (phenylacetyl)aminothiazole; 2- ( (4-chlorophenoxy)methyl) -4-(4-fluorophenyl) -5- [ (4- methylsulfonyl)phenyl] thiazole; 2- (2-chlorophenyl) -4-phenyl-5- [ (4- methylsulfonyl)phenyl]thiazole; 2- (2-chlorophenyl) -4- (3-fluorophenyl) -5- [ (4- methylsulfonyl)phenyl]thiazole; 4- (2,4-difluorophenyl) -2- (2-chlorophenyl) -5- [ (4- methylsulfonyl)phenyl]thiazole; 2- (2-chlorophenyl) -4- (2-methylphenyl) -5.- [ (4- methylsulfonyl)phenyl]thiazole; 2- (2-chlorophenyl) -5-[ (4-methylsulfonyl) ' phenyl] -4- (2- thienyl)thiazole; 2- (2-chlorophenyl) -5-[ (4-methylsulfonyl)phenyl] -4- (3- thienyl) thiazole; 4- (4-fluorophenyl) -5-[ (4-methylsulfonyl)phenyl] -2- (4- pyridyl) thiazole; 2- (2-chlorophenyl) -4- (2-chlorophenyl) -5- [ (4- methylsulfonyl)phenyl]thiazole; 2- (2-chlorophenyl) -4- (4-chlorophenyl) -5- [ (4- methylsulfonyl)phenyl]thiazole; 2- (2-chlorophenyl) -4- (4-methoxyphenyl) -5- [ (4- methylsulfonyl)phenyl]thiazole; 2- (3-chloro-4-fluorophenyl) -4- (4-fluorophenyl) -5- [ (4- methylsulfonyl)phenyl]thiazole; 2- ( (2-thienyl) sulfonyImethyl) -4- (4-fluorophenyl) -5- [ (4- methylsulfonyl)phenyl] thiazole; 2- ( (2-thienyl) sulfonylbromomethyl) -4- (4-fluorophenyl) - 5- [ (4-methylsulfonyl)phenyl]thiazole; 2- (2-chlorophenyl) -5- [ (4-methylsulfonyl)phenyl] -4- (4- methylphenyl) thiazole; 2- (2-chlorophenyl) -4- (4-fluorophenyl) -5-[ (4- methylsulfonyl)phenyl]thiazole; ethyl [4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2- thiazolyl]carboxylate; 2- (cyanomethyl) -4- (4-fluorophenyl) -5- [ (4- methylsulfonyl)phenyl]thiazole; 2- ( ert-butyl) -4- (4-fluorophenyl) -5-[ (4- ethylsulfonyl)phenyl]thiazole; [5- [ (4-methylsulfonyl)phenyl] -4- (4-fluorophenyl) -2- thiazolyl]acetic acid; 4- (4-fluorophenyl) -5- [ (4-methylsulfonyl)phenyl] -2- benzylthiazole; 2- (3- [4-bromophenyl]propyl) -4- (4-fluorophenyl) ) -5- [ (4- methylsulfonyl)phenyl]thiazole; 4- (4-fluorophenyl) -5- [ (4- methylsulfonyl)phenyl]thiazole; 4- (4-fluorophenyl) -5- [ (4-methylsulfonyl)phenyl] -2- trifluoromethylthiazole; 4- (4-fluorophenyl) -5- [ (4-methylsulfonyl)phenyl] -2-(2- thienyl)thiazole; 4- (4-fluorophenyl) -5- [ (4-methylsulfonyl)phenyl] -2- (5- bromo-2-thienyl)thiazole; 4- (4-fluorophenyl) -5- [ (4-methylsulfonyl)phenyl] -2- (3- pyridyl) thiazole; 4- ( -fluorophenyl) -5- [ (4-methylsulfony1)phenyl] -2- methylthiazole; 4- (4-fluorophenyl) -5- [ (4-methylsulfonyl)phenyl] -2- benzylaminothiazole; 4- (4-fluorophenyl) -5- [ (4-methylsulfonyl)phenyl] -2- (1- piperidinyl)thiazole; 4- (4-fluorophenyl) -5- [ (4-methylsulfonyl)phenyl] -2- (1- propylamino)thiazole; 4- [4- (4-bromophenyl) -2- (2-chlorophenyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2-phenyl-5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (4-methoxyphenyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (4-chlorophenyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (N-hexylamino) -5- thiazoly1]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (N-methylamino) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (N-ethylamino) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (N-tert-butylamino) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (N- (4-phenoxyphenyl)amino) -5- thiazolyl]benzenesulfonamide; ethyl 4- [ [5- [ (4-aminosulfonyl)phenyl] -4- (4- fluorophenyl) -2-thiazolyl]amino]benzoate; ethyl 3- [ [5- [ (4-aminosulfonyl)phenyl]-4- (4- fluorophenyl) -2-thiazolyl]amino] enzoate; 4-[4-(4-fluorophenyl)-2-(2-phenylethyl-5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (N- (3, 5-dichlorophenyl)amino) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (N-butylamino) -5- thiazolyl]benzenesulfonamide; 4- [ [5- [ (4-aminosulfonyl)phenyl] -4- (4-fluorophenyl) -2- thiazolyl]amino]benzoic acid; 3- [ [5- [ (4-aminosulfonyl)phenyl] -4- (4-fluorophenyl) -2- thiazolyl]amino] enzoic acid; 4-[4-{4-fluorophenyl)-2-ethyl-5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (3-phenylpropyl) -5- thiazoly1]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3-chlorophenoxy)methyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (2-methyl-4-thiazolyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (2-fluorophenyl) -2- (2-chlorophenyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (2, 5-difluorophenyl) -2- (2-chlorophenyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (2,3,4, 5, 6-pentafluorophenyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (2-chlorophenoxy)methyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (2-fluorophenyl) -2- ( (3-chlorophenoxy)methyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3, 5-dichlorophenoxy)methyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (2-fluorophenyl) -2- ( (4-methoxyphenoxy)methyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-bromophenyl) -2- (2-chlorophenyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-methylthiophenyl) -2- (2-chlorophenyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (3-fluoro-4-methoxyphenyl) -2- (2-chlorophenyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (3-chloro-4-methoxyphenyl) -2- (2-chlorophenyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (3-chloro-4-methylphenyl) -2- (2-chlorophenyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (3-methyl-4-chlorophenyl) -2- (2-chlorophenyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (3,4-methylenedioxyphenyl) -2- (2-chlorophenyl) - 5-thiazolyl]benzenesulfonamide; • 4- [4- (3, 5-difluoro-4-methoxyphenyl) -2- (2-chlorophenyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (3, 5-dichloro-4-methoxyphenyl) -2- (2-chlorophenyl) - 5-thiazolyl]benzenesulfonamide; 4-[4- (4-fluorophenyl) -2- (difluoromethyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (methylthio) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (phenylthio) -5- thiazolyl]benzenesulfonamide; 4-[4- (4-fluorophenyl) -2- ( (3-fluorophenyl)thio) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3-chlorophenyl) thio) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2-( (3-bromopheny1) thio) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3,5-difluorophenyl) thio) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- [ (3, 5-dichlorophenyl) thio] - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- [ (4-fluorophenyl)thio] - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- [ (4-chlorophenyl)thio] - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- [ (4-bromopheny1)thio] -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-methylphenyl) thio) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (benzylthio) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3-fluorobenzyl) thio) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3-chlorobenzyl)thio) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3-bromobenzyl) thio) -5- thiazoly1]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2-( (3,5-difluorobenzyl) thio) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3, 5-dichlorobenzyl) thio) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-fluorobenzyl)thio) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- { (4-chlorobenzyl)thio) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-bromobenzyl) thio) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-methylbenzyl) thio) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (ethylsulfonyl) -5- thiazoly1]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (methylsulfonyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (phenylsulfonyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3-fluorophenyl) sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3-chlorophenyl) sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3-bromopheny1) sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4_ (4-fluorophenyl) -2- ( (3, 5-difluorophenyl) sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3, 5-dichlorophenyl) sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-fluorophenyl)sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-chlorophenyl) sulfonyl)- 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-bromopheny1)sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-methylphenyl) sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (benzylsulfonyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3-fluorobenzyl) sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3-chlorobenzyl)sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3-bromobenzyl) sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3, 5-difluorobenzyl) sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3,5-dichlorobenzyl) sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-fluorobenzyl)sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-chlorobenzyl) sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-bromobenzyl)sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-methylbenzyl) sulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (fluoromethylsulfonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (acetyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (trifluoroacetyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2-(benzoyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (3-fluorobenzoyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (3-chlorobenzoyl) -5- thiazolyl]benzenesulfonamide; 4-[4- (4-fluorophenyl) -2- (3-bromobenzoyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (3,5-difluorobenzoyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (3, 5-dichlorobenzoyl) -5- thiazoly1]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (4-fluorobenzoyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (4-chlorobenzoyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (4-bromobenzoyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2-(4-methylbenzoyl) -5- thiazolyl]benzenesulfonamide; methyl [5-[ (4-aminosulfonyl)phenyl] -4- (4-fluorophenyl) - 2-thiazolyl] carboxylate; ethyl [5- [ (4-aminosulfonyl)phenyl] -4- (4-fluorophenyl) - 2-thiazolyl] carboxylate; propyl [5-[ (4-aminosulfonyl)phenyl] -4- (4-fluorophenyl) - 2-thiazolyl] carboxylate; butyl [5- [ (4-aminosulfonyl)phenyl] -4- (4-fluorophenyl) - 2-thiazolyl] carboxylate; 4- [4- (4-fluorophenyl) -2- (hydroxymethyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (methoxymethyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (phenoxymethyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (3-fluorophenoxymethyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (3-chlorophenoxymethyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (3-bromophenoxymethyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (3, 5-difluorophenoxymethyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (3, 5-dichlorophenoxyτnethyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (4-fluorophenoxymethyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (4-chlorophenoxymethyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (4-bromophenoxymethy1) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2-(4-methylphenoxymethyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (benzyloxymethyl) -5- thiazolyl]benzenesulfonamide; 4- [4-(4-fluorophenyl) -2- (cyanomethyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (2-quinolylmethyloxymethyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (2-naphthylmethyloxymethyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (N-phenylaminocarbonyl) -5- thiazolyl]benzenesulfonamide; 4-[4-(4-fluorophenyl)-2-[(3- fluorophenyl)aminocarbonyl] -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- [ (3- chlorophenyl)aminocarbonyl] -5- thiazolyl]benzenesulfonamide; 4- [4- ( -fluorophenyl) -2- [ (3-bromophenyl)aminocarbonyl] - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- [ (3,5- difluorophenyl)aminocarbonyl] -5- thiazolyl] enzenesulfonamide; 4- [4- (4-fluorophenyl) -2- [ (3,5- dichlorophenyl)aminocarbonyl] -5- thiazolyl]benzenesulfonamide; 4- [4-(4-fluorophenyl) -2-[ (4- fluorophenyl)aminocarbonyl] -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- [ (4- chlorophenyl)aminocarbonyl] -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- [ (4-bromophenyl)aminocarbonyl] - 5-thiazolyl]benzenesulfonamide; 4 - [ 4 - ( 4- f luorophenyl ) -2 - [ ( 4 - ethylphenyl)aminocarbonyl] -5- thiazolyl]benzenesulfonamide; - [4- (4-fluorophenyl) -2- (benzylaminocarbonyl) -5- thiazolyl]benzenesulfonamide; 4-[4-(4-fluorophenyl) -2-( (3- fluorobenzyl)aminocarbonyl) -5- thiazolyl]benzenesulfonamide, • 4_[4_ (4_fluorophenyl) -2-( (3- chlorobenzyl)aminocarbonyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3-bromobenzyl)aminocarbonyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3,5- difluorobenzyl)aminocarbonyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3,5- dichlorobenzyl)aminocarbonyl) -5- thiazolyl]benzenesulfonamide; 4-[4-(4-fluorophenyl)-2-( (4- fluorobenzyl)aminocarbonyl) -5- thiazolyl]benzenesulfonamide; 4-[4-(4-fluorophenyl)-2-( (4- chlorobenzyl)aminocarbonyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-bromobenzyl)aminocarbonyl) - 5-thiazolyl]benzenesulfonamide; 4-[4-{4-fluorophenyl)-2-( (4- methylbenzyl)aminocarbonyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (benzoylamino) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3-fluorobenzoyl)amino) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3-chlorobenzoyl)amino) -5- thiazoly1]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3-bromobenzoyl)amino) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3, 5-difluorobenzoyl)amino) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3, 5-dichlorobenzoyl)amino) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-fluorobenzoyl)amino) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-chlorobenzoylamino) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-bromobenzoyl)amino) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (4-methylbenzoyl)amino) - 5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (phenylacetyl)amino-5- thiazolyl]benzenesulfonamide; 4- [2- ( (4-chlorophenoxy)methyl) -4- (4-fluorophenyl) -5- thiazolyl]benzenesulfonamide; 4- [2- (2-chlorophenyl) -4-phenyl- 5-thiazolyl]benzenesulfonamide; 4- [2- (2-chlorophenyl) -4- (3-fluorophenyl) - 5-thiazolyl]benzenesulfonamide; 4- [4- (2, 4-difluorophenyl) -2- (2-chlorophenyl) - 5-thiazolyl]benzenesulfonamide; 4- [2- (2-chlorophenyl) -4- (2-methylphenyl) - 5-thiazolyl]benzenesulfonamide; 4- [2- (2-chlorophenyl) -4- (2-thienyl) -5- thiazolyl]benzenesulfonamide; 4- [2- (2-chlorophenyl)-4-(3-thienyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (4-pyridyl) -5- thiazolyl]benzenesulfonamide; 4- [2- (2-chlorophenyl) -4- (2-chlorophenyl) - 5-thiazolyl]benzenesulfonamide; 4-[2-(2-chlorophenyl)-4- (4-chlorophenyl) - 5-thiazolyl]benzenesulfonamide; 4- [2- (2-chlorophenyl) -4- (4-methoxyphenyl) - 5-thiazolyl]benzenesulfonamide; 4- [2- (3-chloro-4-fluorophenyl) -4- (4-fluorophenyl) - 5-thiazolyl]benzenesulfonamide; 4- [2- ( (2-thienyl) sulfonyImethyl) -4- (4-fluorophenyl) - 5-thiazolyl]benzenesulfonamide; 4- [2- { (2-thienyl) sulfonylbromomethyl) -4- (4- fluorophenyl) -5-thiazolyl]benzenesulfonamide; 4- [2- (2-chlorophenyl) -4- (4-methylphenyl) -5- thiazolyl]benzenesulfonamide; ethyl [4- (4-fluorophenyl) -5- [ (4-aminosulfonyl)phenyl] - 2-thiazolyl] carboxylate; 4- [2- (cyanomethyl) -4- (4-fluorophenyl) -5- thiazolyl]benzenesulfonamide; 4-[2-(tert-butyl) -4- (4-fluorophenyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2-benzyl-5- thiazolyl]benzenesulfonamide; 4- [2- (3- [4-bromopheny1]propyl)-4- (4-fluorophenyl) ) -5- thiazolyl]benzenesulfonamide; 4-[4- (4-fluorophenyl)-5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2-trifluoromethyl-5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (2-thienyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (5-bromo-2-thienyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (3-pyridyl) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2-methyl-5- thiazolyl]benzenesulfonamide; 4- [4- (4-chlorophenyl) -2-methyl-5- thiazoly1]benzenesulfonamide; 4- [4- (3-fluoro-4-methoxyphenyl) -2-methyl-5- thiazolyl]benzenesulfonamide; 4- [4-phenyl-2-methyl-5-thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2-benzylamino-5- thiazoly1]benzenesulfonamide; 4- [4- (3-fluoro-4-methoxyphenyl) -2-benzylamino-5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (1-piperidiny1) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (1-propylamino) -5- thiazolyl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- (2-chlorophenyl) thiazol-5- yl]benzenesulfonamide; 4- [4- (4-fluorophenyl) -2- ( (3, 5-dichlorophenoxy)methyl) -5-thiazolyl]benzenesulfonamide; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (trifluoromethyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-chlorophenyl) -2- (2- chlorophenyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-methoxyphenyl) -2- (2- chlorophenyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-methylphenyl) -2- (2- chlorophenyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-bromophenyl) -2- (2- chlorophenyl) thiazole; 4-[ (4-methylsulfonyl)phenyl] -5- (4-methylthiophenyl) -2- (2-chlorophenyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (3-fluoro-4- methoxyphenyl)-2- (2-chlorophenyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (3-chloro-4- methoxyphenyl) -2- (2-chlorophenyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (3-chloro-4- methylphenyl) -2- (2-chlorophenyl) thiazole; 4-[ (4-methylsulfonyl)phenyl] -5- (3-methyl-4- chlorophenyl) -2- (2-chlorophenyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (3,4- methylenedioxyphenyl) -2- (2-chlorophenyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (3, 5-difluoro-4- methoxyphenyl) -2- (2-chlorophenyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (3, 5-dichloro-4- methoxyphenyl) -2- (2-chlorophenyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- methylthiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (3-fluoro-4- methoxyphenyl) -2- (2-methyl-4-thiazolyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (difluoromethyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (methylthio) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (phenylthio) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- fluoro-phenylthio)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- chloro-phenylthio)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- bromo-phenylthio) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3, 5- difluoro-phenylthio) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3,5- dichloro-phenylthio)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl)-2- (4- fluoro-phenylthio) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- chloro-phenylthio) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- bromo-phenylthio)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- methyl-phenylthio) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (benzylthio) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- fluorobenzylthio) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- chlorobenzylthio) thiazole; 4- t (4-methylsulfonyl)phenyl] -5- (4 fluorophenyl) -2--(3- bromobenzylthio)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4 fluorophenyl) -2- -(3,5 difluorobenzylthio)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4 fluorophenyl) -2- -(3,5 dichlorobenzylthio)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4 fluorophenyl) -2- ■ (4- fluorobenzylthio) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4 fluorophenyl) -2- -(4- chlorobenzylthio)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5 4-fluorophenyl bromobenzylthio) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- -(4- methylbenzylthio) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- {ethylsulfonyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (methylsulfonyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (phenylsulfonyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- ■ (3- fluorophenylsulfonyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- chlorophenylsulfonyl) thiazole; 4-[ (4-methylsulfonyl)phenyl]-5- (4-fluorophenyl) -2- ■ (3- bromophenylsulfonyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- -(3,5 difluorophenylsulfonyl)thiazole ; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- -(3,5 dichlorophenylsulfonyl) thiazole ; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- -(4- fluorophenylsulfonyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4- fluorophenyl) -2- -(4- chlorophenylsulfonyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- -(4- bromophenylsulfonyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- methylphenylsulfonyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (benzylsulfonyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- fluorobenzylsulfonyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- chlorobenzylsulfonyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- bromobenzylsulfonyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3, 5- difluorobenzylsulfonyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3 , 5- dichlorobenzylsulfonyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- fluorobenzylsulfonyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- chlorobenzylsulfonyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- bromobenzylsulfonyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- methylbenzylsulfonyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (fluoromethylsulfonyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (acetyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (trifluoroacetyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (benzoyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- fluorobenzoyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- chlorobenzoyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- bromobenzoyl) hiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3, 5- difluorobenzoyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3, 5- dichlorobenzoyl) hiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- fluorobenzoyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- chlorobenzoyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- bromobenzoyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- methylbenzoyl) thiazole; [4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- thiazolyl]acetic acid; [4-[ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- thiazolyl]propanoic acid; [4-[ (4-methylsulfonyl)phenyl]-5- (4-fluorophenyl) -2- thiazolyl]butanoic acid; [4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- thiazolyl]pentanoic acid; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (hydroxymethyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (methoxymethyl)thiazole; 4-[ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (phenyloxymethyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- fluorophenyloxymethyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- chlorophenyloxymethyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- bromophenyloxymethyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3,5- difluorophenyloxymethyl) thiazole; 4-[ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3 , 5- dichlorophenyloxymethyl)'thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- fluorophenyloxymethyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- chlorophenyloxymethyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- bromophenyloxymethyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- methylphenyloxymethyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (benzyloxymethyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (cyanomethyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (2- quinolylmethyloxymethyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (2- naphthylmethyloxymethy1)thiazole; 4- f (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (N- phenylaminocarbonyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (3- fluorophenyl)aminocarbonyl] thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (3- chloropheny1)aminocarbonyl]thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (3- bromophenyl)aminocarbonyl] thiazole; 4-[ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (3, 5-difluorophenyl)aminocarbonyl]thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (3, 5-dichlorophenyl)aminocarbonyl] thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (4- fluorophenyl)aminocarbonyl] thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (4- chlorophenyl)aminocarbonyl] thiazole; 4- (4-methylsulfonyl) -5- (4-fluorophenyl) -2- [ (4- bromophenyl)aminocarbonyl] thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (4- methylpheny1)aminocarbonyl] thiazole; 4- [ (4-methylsulfonyl)phenyl] -5-(4-fluorophenyl) -2- (benzylaminocarbonyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- fluorobenzylaminocarbonyl) thiazole; 4- t (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- chlorobenzylaminocarbonyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2-(3- bromobenzylaminocarbonyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3, 5- difluorobenzylaminocarbonyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3, 5- dichlorobenzylaminocarbonyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- fluorobenzylaminocarbonyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- chlorobenzylaminocarbonyl) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- bromobenzylaminocarbonyl)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2-(4- methylbenzylaminocarbonyl)thiazole; 4- [ (4-methylsulfonyl)phenyl]-5-(4-fluorophenyl) -2- (benzoylamino) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- fluorobenzoylamino)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- chlorobenzoylairri.no)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3- bromobenzoylamino)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3,5- difluorobenzoylamino) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (3, 5- dichlorobenzoylairri.no)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- fluorobenzoylairri.no) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- chlorobenzoylamino)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- bromobenzoylamino)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (4- methylbenzoylamino) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (phenylacetyl)aminothiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (3- fluorophenyl)acetyl]aminothiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (3- chlorophenyl)acetyl]aminothiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (3- bro ophenyl)acetyl]amino)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (3, 5-difluorophenyl)acetyl]amino) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (3, 5-dichlorophenyl)acetyl]amino)thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (4- fluorophenyl)acetyl]amino) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (4- chlorophenyl)acetyl]amino) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (4- bromophenyl) acetyl]amino) thiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- [ (4- methylphenyl)acetyl]amino) thiazole; 4-[ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (fluoromethylsulfonyl)aminothiazole; 4- [ (4-methylsulfonyl)phenyl] -5- (4-fluorophenyl) -2- (methylsulfonyl)aminothiazole; 4- [5- (4-chlorophenyl) -2-methyl-4- thiazolyl]benzenesulfonamide; 4- [5- (4-bromophenyl) -2-methyl-4- thiazolyl]benzenesulfonamide; 4- [2-methyl-5-phenyl-4-thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (trifluoromethyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-bromophenyl) -2- (2-chlorophenyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-methylthiophenyl) -2- (2-chlorophenyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (3-fluoro-4-methoxyphenyl) -2- (2-chlorophenyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (3-chloro-4-methoxyphenyl) -2- (2-chlorophenyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (3-chloro-4-methylphenyl)-2- (2-chlorophenyl)-4- thiazolyl]benzenesulfonamide; 4- [5- (3-methyl-4-chlorophenyl) -2- (2-chlorophenyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (3, 4-methylenedioxyphenyl) -2- (2-chlorophenyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (3, 5-difluoro-4-methoxyphenyl) -2- (2-chlorophenyl) - 4-thiazolyl]benzenesulfonamide; 4- [5- (3, 5-dichloro-4-methoxyphenyl) -2- (2-chlorophenyl) - -thiazolyl]benzenesulfonamide; 4- [5- (4-chlorophenyl) -2- (2-chlorophenyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-methoxyphenyl) -2- (2-chlorophenyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-methylphenyl) -2- (2-chlorophenyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (difluoromethyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (methylthio) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (phenylthio) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3-fluorophenyl)thio) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3-chlorophenyl)thio) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3-bromophenyl)thio) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2-( (3,5-difluorophenyl) thio) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- [ (3, 5-dichlorophenyl) thio] -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- [ (4-fluorophenyl) thio] -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- [ (4-chlorophenyl)thio] -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- [ (4-bromophenyl)thio] -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4-methylphenyl) thio) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (benzylthio) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3-fluorobenzyl)thio) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3-chlorobenzyl)thio) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3-bromobenzyl) thio) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3, 5-difluorobenzyl) thio) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3, 5-dichlorobenzyl) thio) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4-fluorobenzyl)thio) -4- thiazoly1]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4-chlorobenzyl) thio) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4-bromobenzyl)thio) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4-methylbenzyl) thio) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (ethylsulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (methylsulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (phenylsulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3-fluorophenyl) sulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3-chlorophenyl) sulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3-bromophenyl) sulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3,5-difluorophenyl) sulfonyl) - 4-thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3, 5-dichlorophenyl) sulfonyl) - 4-thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4-fluorophenyl) sulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4-chlorophenyl)sulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4-bromophenyl) sulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4-methylphenyl) sulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (benzylsulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3-fluorobenzyl) sulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3-chlorobenzyl) sulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3-bromobenzyl)sulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3,5-difluorobenzyl) sulfonyl) - 4-thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3,5-dichlorobenzyl) sulfonyl) - 4-thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- { (4-fluorobenzyl) sulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4-chlorobenzyl) sulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4-bromobenzyl) sulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4-methylbenzyl) sulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2 - (fluoromethylsulfonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (acetyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (trifluoroacetyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (benzoyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (3-fluorobenzoyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (3-chlorobenzoyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (3-bromobenzoyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (3, 5-difluorobenzoyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (3, 5-dichlorobenzoyl) -4- thiazolyl] enzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (4-fluorobenzoyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (4-chlorobenzoyl) -4- thiazoly1]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (4-bromobenzoyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (4-methylbenzoyl) -4- thiazolyl] enzenesulfonamide; methyl [4-[ (4-aminosulfonyl)phenyl] -5- (4-fluorophenyl) - 2-thiazolyl] carboxylate; ethyl [4- [ (4-aminosulfonyl)phenyl] -5- (4-fluorophenyl) - 2-thiazolyl] carboxylate; propyl [4- [ (4-aminosulfonyl)phenyl) -5- (4-fluorophenyl) - 2-thiazolyl] carboxylate; butyl [4- [ (4-aminosulfonyl)phenyl] -5- (4-fluorophenyl) - 2-thiazolyl] carboxylate; 4- [5- (4-fluorophenyl) -2- (hydroxymethyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (methoxymethyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (phenoxymethy1) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (3-fluorophenoxymethyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (3-chlorophenoxymethyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (3-bromophenoxymethyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (3, 5-difluorophenoxymethyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (3, 5-dichlorophenoxymethyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (4-fluorophenoxymethyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (4-chlorophenoxymethyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (4-bromophenoxymethy1) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (4-methylphenoxymethyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (benzyloxymethyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (cyanomethyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (2-quinolylmethyloxymethyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (2-naphthyImethyloxymethyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (N-phenylaminocarbonyl) -4- thiazolyl]benzenesulfonamide; 4-[5-(4-fluorophenyl)-2-[ (3- fluorophenyl) minocarbonyl] -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- [ (3- chlorophenyl)aminocarbonyl] -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- [ (3-bromophenyl)aminocarbonyl] - 4-thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- [ (3,5- difluorophenyl)aminocarbonyl] -4- thiazolyl]benzenesulfonamide; 4-[5-(4-fluorophenyl)-2-[ (3,5- dichlorophenyl)aminocarbonyl] -4- thiazolyl]benzenesulfonamide; 4-[5-(4-fluorophenyl)-2-[ (4- fluorophenyl)aminocarbonyl] -4- thiazoly1]benzenesulfonamide; 4-[5-(4-fluorophenyl)-2-[ (4- chlorophenyl)aminocarbonyl] -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- [ (4-bromophenyl)aminocarbonyl] - 4-thiazolyl]benzenesulfonamide; 4-[5-(4-fluorophenyl)-2-[ (4- methylphenyl)aminocarbonyl] -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (benzylaminocarbonyl) -4- thiazolyl]benzenesulfonamide; 4-[5-(4-fluorophenyl)-2-( (3- fluorobenzyl)aminocarbonyl) -4- thiazolyl]benzenesulfonamide; , 4- [5- (4-fluorophenyl) -2- ( (3-chlorobenzyl)aminocarbonyl) -4-thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3-bromobenzyl)aminocarbonyl) - 4-thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3,5- difluorobenzyl)aminocarbonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3,5- dichlorobenzyl)aminocarbonyl) -4- thiazolyl]benzenesulfonamide; 4 - [ 5 - ( 4 - fluorophenyl ) -2 - ( ( 4- fluorobenzyl)aminocarbonyl) -4- thiazoly1]benzenesulfonamide; 4-[5-(4-fluorophenyl)-2-( (4- chlorobenzyl)aminocarbonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4-bromobenzyl)aminocarbonyl) - 4-thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4- methylbenzy1)aminocarbonyl) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- (benzoylamino) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3-fluorobenzoyl)amino) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3-chlorobenzoyl)amino)-4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3-bromobenzoyl)amino) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3, 5-difluorobenzoyl)amino) -4- thiazoly1]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (3, 5-dichlorobenzoyl)amino) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4-fluorobenzoyl)amino) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4-chlorobenzoylamino) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2- ( (4-bromobenzoyl)amino) -4- thiazolyl]benzenesulfonamide; 4- [5- (4-fluorophenyl) -2-( (4-methylbenzoyl)amino) -4- thiazolyl]benzenesulfonamide; and 4- [5- (4-fluorophenyl) -2- (phenylacetyl)amino-4- thiazolyl]benzenesulfonamide. Within Formula I there is a subclass of compounds of high interest represented by Formula II: wherein R^ is selected from alkyl and amino; wherein R 5 is selected from aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R 5 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, aminosulfonyl, alkyl, alkenyl, alkynyl, cyano, carboxyl, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, acyl, N- alkylaminocarbonyl, N-arylaminocarbonyl, N,N- dialkylaminocarbony1, N-alky1-N-arylaminocarbonyl, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, haloalkoxy, amino, N-alkylamino, N,N-dialkylamino, heterocyclic and nitro; and wherein R 6 is selected from halo, amino, alkoxy, nitro, hydroxyl, aminocarbonyl, acyl, alkylaminocarbonyl, arylaminocarbonyl, alkenyl, alkynyl, haloalkoxy, alkylamino, arylamino, aralkylamino, alkoxycarbonylalkyl, alkylaminoalkyl, heterocycloalkyl, aralkyl, cyanoalkyl, N- alkylsulfonylairri.no, heteroarylsulfonylaikyl, heteroarylsulfonylhaloalkyl, aryloxyalkyl, aralkyloxyalkyl, aryl and heterocycio, wherein the aryl and heterocycio radicals are optionally substituted at a substitutable position with one or more radicals selected from halo, alkyl, alkoxy, alkylthio, alkylsulfinyl, haloalkyl, haloalkoxy, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, amino, acyl and alkylamino; or a pharmaceutically-acceptable salt thereof. A preferred class of compounds consists of those compounds of Formula II wherein R^ is selected from lower alkyl and amino; wherein R 5 is selected from aryl, lower cycloalkyl, lower cycloalkenyl and heteroaryl; wherein R 5 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower haloalkylsulfonyl, aminosulfonyl, lower alkyl, lower alkenyl, lower alkynyl, cyano, carboxyl, lower carboxyalkyl, lower alkoxycarbonyl, aminocarbonyl, acyl, lower N-alkylaminocarbonyl, lower N- arylaminocarbonyl, lower N,N-dialkylaminocarbonyl, lower N-alkyl-N-arylaminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, amino, lower N-alkylamino, lower N,N- dialkylamino, heterocyclic and nitro; and wherein R 6 is selected from halo, amino, lower alkoxy, nitro, hydroxyl, aminocarbonyl, acyl, lower alkylaminocarbonyl, lower arylammocarbonyl, lower alkenyl, lower alkynyl, lower haloalkoxy, lower alkylamino, phenylamino, lower aralkylamino, lower alkoxycarbonylalkyl, lower alkylaminoalkyl, lower heterocycloalkyl, lower aralkyl, lower cyahoalkyl, lower N-alkylsulfonylamino, lower heteroarylsulfonylaikyl, lower heteroarylsulfonylhaloalkyl, lower aryloxyalkyl, lower aralkyloxyalkyl, phenyl optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower haloalkyl, lower haloalkoxy, lower carboxyalkyl, lower alkoxycarbonyl, aminocarbonyl, amino, acyl and lower alkylamino, and heterocyclic optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower haloalkyl, lower haloalkoxy, lower carboxyalkyl, lower alkoxycarbonyl, aminocarbonyl, amino, acyl and lower alkylamino; or a pharmaceutically-acceptable salt thereof. Within Formula I there is a second subclass of compounds of high interest represented by Formula III: R 4 S0 2 III - «' N R 5 wherein R^ is selected from alkyl and amino; wherein R 5 is selected from aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R 5 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, aminosulfonyl, alkyl, alkenyl, alkynyl, cyano, carboxyl, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, acyl, N- alkylaminocarbonyl, N-arylaminocarbonyl, N,N- dialkylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, haloalkoxy, amino, N-alkylamino, N,N-dialkylamino, heterocyclic and nitro; and wherein R 7 is selected from hydrido, alkyl, haloalkyl, cyano, hydroxyalkyl, alkoxyalkyl, carboxyl, carboxyalkyl, and alkoxycarbonyl; provided that R 5 is not 4-fluorophenyl when R 7 is methyl; further provided R 5 is not phenyl substituted with α,α -bis (methyl)methanol; and further provided that R 4 is not methyl when R 7 is α,α -bis (trifluoromethyl)methanol; or a pharmaceutically- acceptable salt thereof. A preferred class of compounds consists of those compounds of Formula III wherein R^ is selected from lower alkyl and amino; wherein R 5 is selected from aryl, lower cycloalkyl, lower cycloalkenyl and heteroaryl; wherein R 5 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower haloalkylsulfonyl, aminosulfonyl, lower alkyl, lower alkenyl, lower alkynyl, cyano, carboxyl, lower carboxyalkyl, lower alkoxycarbonyl, aminocarbonyl, acyl, lower N-alkylaminocarbonyl, lower N- arylaminocarbonyl, lower N,N-dialkylaminocarbonyl, lower N-alkyl-N-arylaminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, amino, lower N-alkylamino, lower N,N- dialkylamino, heterocyclic and nitro; and wherein R 7 is selected from hydrido, lower alkyl, lower haloalkyl, cyano, lower hydroxyalkyl, lower alkoxyalkyl, carboxyl, lower carboxyalkyl, and lower alkoxycarbonyl; or a pharmaceutically-acceptable salt thereof. Within Formula I there is a third subclass of compounds of high interest represented by Formula IV: wherein R 1 is selected from hydrido, halo, amino, alkoxy, cyano, nitro, hydroxyl, aminocarbonyl, acyl, alkylaminocarbonyl, arylaminocarbonyl, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, alkylamino, arylamino, aralkylammo, carboxyl, carboxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkylaminoalkyl, heterocycloalkyl, aralkyl, hydroxyalkyl, alkoxyalkyl, cyanoalkyl, N-alkylsulfonylamino, heteroarylsulfonylaikyl, heteroarylsulfonylhaloalkyl, aryloxyalkyl, aralkyloxyalkyl, aryl and heterocycio, wherein the aryl and heterocycio radicals are optionally substituted at a substitutable position with one or more radicals selected from halo, alkyl, alkoxy, alkylthio, alkylsulfinyl, haloalkyl, haloalkoxy, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, amino, acyl and alkylamino; wherein R 4 is selected from alkyl and amino; and wherein R 8 is heterocyclic; wherein R 8 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkyl, alkenyl, alkynyl, cyano, carboxyl, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, acyl, N-alkylaminocarbonyl, N- arylaminocarbonyl, N,N-dialkylaminocarbonyl, N-alkyl- N-arylaminocarbonyl, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, haloalkoxy, amino, N-alkylamino, N,N- dialkylamino, and nitro; or a pharmaceutically-acceptable salt thereof. A preferred class of compounds consists of those compounds of Formula IV wherein R 1 is selected from hydrido, halo, amino, lower alkoxy, cyano, nitro, hydroxyl, aminocarbonyl, acyl, lower alkylaminocarbonyl, phenylaminocarbonyl, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, lower haloalkoxy, lower alkylamino, phenylamino, lower aralkylammo, carboxyl, lower carboxyalkyl, lower alkoxycarbonyl, lower alkoxycarbonylalkyl, lower alkylaminoalkyl, lower heterocycloalkyl, lower aralkyl, lower hydroxyalkyl, lower alkoxyalkyl, lower cyanoalkyl, lower N-alkylsulfonylamino, lower heteroarylsulfonylaikyl, lower heteroarylsulfonylhaloalkyl, lower aryloxyalkyl, aralkyloxyalkyl, aryl optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower haloalkyl, lower haloalkoxy, lower carboxyalkyl, lower alkoxycarbonyl, aminocarbonyl, amino, acyl and lower alkylamino, and heterocyclic optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower haloalkyl, lower haloalkoxy, lower carboxyalkyl, lower alkoxycarbonyl, aminocarbonyl, amino, acyl and lower alkylamino; wherein R 4 is selected from lower alkyl and amino; and wherein R 8 is nitrogen-containing heteroaryl optionally substituted at a substitutable position with one or more substituents independently selected from halo, alkyl, alkoxy, alkylthio, amino and alkylamino; or a pharmaceutically-acceptable salt thereof. A class of compounds of particular interest consists of those compounds of Formula IV wherein R 1 is selected from hydrido, methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, tert-butyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, cyanomethyl, cyanoethyl, cyanopropyl, methylamino, ethylamino, propylamino, butylamino, ter -butylamino, pentylamino, hexylamino, phenethyl, phenylpropyl, benzyl, phenylamino, thienylsulfonyImethyl, thienylsulfonylbromomethyl, benzylamino, phenoxymethyl, 3,5-dichlorophenylairri.no, 3,5-dichlorophenoxymethyl, 3-chlorophenoxymethyl, methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl, ter -butoxycarbonyl, ' propoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, pentoxycarbonyl, phenyl optionally substituted at a substitutable position with one or more radicals selected from fluoro, chloro, bromo, methoxy, ethoxy, propoxy, butoxy, isopropoxy and tert- butoxy, and a heterocyclic radical selected from thienyl, pyridyl, furyl, oxazolyl, pyrimidinyl, pyrazinyl, quinolyl, isoquinolinyl, imidazolyl, thiazolyl, pyrrolyl, pyrazolyl and triazolyl, optionally substituted at a substitutable position with one or more radicals selected from fluoro, chloro, bromo, methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl and tert-butyl; wherein R 4 is methyl or amino; and wherein R 8 is selected from pyridyl, thienyl, thiazolyl, oxazolyl, pyrimidinyl, pyrazinyl, quinolyl, isoquinolinyl, imidazolyl, and benzimidazolyl, wherein R 8 is optionally substituted at a substitutable position with one or more substituents independently selected from fluoro, chloro, bromo, methyl, ethyl, isopropyl, tert-butyl, isobutyl, methoxy, ethoxy, isopropoxy, tert-butoxy, propoxy, butoxy, isobutoxy, pentoxy, methylthio, amino, N-methylamino and N,N-dimethylamino; or a pharmaceutically-acceptable salt thereof. A family of specific compounds of particular interest within Formula IV consists of compounds and pharmaceutically-acceptable salts thereof as follows : 2- (2-chlorophenyl) -4- (4-pyridyl) -5- (4- methylsulfonylphenyl)thiazole; 2- (3-chloro-4-fluorophenyl) -4- (4-pyridyl) -5- (4- methylsulfonylphenyl)thiazole; 5- (4-pyridyl) -4- (4-methylsulfonylphenyl) -2- methylthiazole; 4- (4-pyridyl) -5- (4-methylsulfonylphenyl) -2- trifluoromethylthiazole; 4- (4-pyridyl) -5- (4-methylsulfonylphenyl) -2- (2- thienyl) thiazole; 4- (4-pyridyl) -5- (4-methylsulfonylphenyl) -2- benzylaminothiazole; 4- (4-pyridyl) -5- (4-methylsulfonylphenyl) -2- (1- propylamino)thiazole; 2- [ (3,5-dichlorophenoxy)methyl) -4- (4-pyridyl) -5- [4- (methylsulfonyl)phenyl]thiazole; 2- (2-chlorophenyl) -4- (4-pyrazinyl) -5- (4- methylsulfonylphenyl)thiazole; 2- ( (3-chlorophenoxy)methyl) -4- (4-pyridyl) -5- (4- methylsulfonylphenyl)thiazole; 4- (4-pyridyl) -5- [4- (methylsulfonyl)phenyl] -2- (2- methyl-4-thiazolyl)thiazole; 4- (4-pyridyl) -2- [ (4-methoxyphenoxy)methyl] -5- [4- (methylsulfonyl)phenyl]thiazole; 4- (4-pyridyl) -5- (4-methylsulfonylphenyl) -2- pheny1thiazole; 4- (4-pyridyl) -2-n-hexylamino-5- (4- methylsulfonylphenyl) thiazole; 2-butylamino-4- (4-pyridyl) -5- (4- methylsulfonylphenyl)thiazole; 4- (4-pyridyl) -5- (4-methylsulfonylphenyl) -2- methylaminothiazole; 4- (4-pyridyl) -5- (4-methylsulfonylpheny1) -2- (4- methoxyphenyl) thiazole; 2-ethylamino-4- (4-pyridyl) -5- (4-methylsulfonylphenyl) - thiazole; 2-tert-butylamino-4-(4-pyridyl) -5-(4- methylsulfonylphenyl)thiazole; 2- (3 , 5-dichlorophenylairri.no) -4- (4-pyridyl) -5- (4- methylsulfonylphenyl)thiazole; 5- (4-pyridyl)-4- (4-methylsulfonylphenyl) -2- trifluoromethylthiazole; and 4- (4-pyridyl) -5- (4-methylsulfonylphenyl) -2- (2,3,4,5,6- pentafluorophenyl)thiazole. Compounds of Formula IV would also be capable of inhibiting cytokines, such as TNF, IL-1, IL-6, and IL-8. As such, the compounds can be used in the manufacture of a medicament or in a method for the treatment for the prophylactic or therapeutic treatment of diseases mediated by cytokines, such as TNF, IL-1, IL-6, and IL- 8. The term "hydrido" denotes a single hydrogen atom (H) . This hydrido radical may be attached, for example, to an oxygen atom to form a hydroxyl radical or two hydrido radicals may be attached to a carbon atom to form a methylene (-CH2-) radical. Where the term "alkyl" is used, either alone or within other terms such as "haloalkyl", "alkylsulfonyl" , "alkoxyalkyl" and "hydroxyalkyl", embraces linear or branched radicals having one to about twenty carbon atoms or, preferably, one to about twelve carbon atoms. More preferred alkyl radicals are "lower alkyl" radicals having one to about ten carbon atoms. Most preferred are lower alkyl radicals having one to about six carbon atoms. Examples of such radicals include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, iso-amyl, hexyl and the like. Where the term "alkenyl" is used, it embraces linear or branched carbon carbon double bond-containing radicals having two to about twenty carbon atoms or, preferably, two to about twelve carbon atoms . More preferred alkenyl radicals are "lower alkenyl" radicals having two to about six carbon atoms. Suitable "lower alkenyl" may be a straight or branched one such as vinyl, allyl, isopropenyl, propenyl, butenyl, pentenyl or the like, in which preferably one is isopropenyl. Said lower alkenyl may be substituted with cyano. Where the term "alkynyl" is used, it embraces linear or branched carbon carbon triple bond-containing radicals having two to about twenty carbon atoms or, preferably, two to about twelve carbon atoms . More preferred alkynyl radicals are "lower alkynyl" radicals having two to about six carbon atoms. Suitable "lower alkynyl" may be a straight or branched radical such as ethynyl, propynyl, propargyl or the like, in which preferably one is propargyl. The term "halo" means halogens such as fluorine, chlorine, bromine or iodine. The term "haloalkyl" embraces radicals wherein any one or more of the alkyl carbon atoms is substituted with halo as defined above. Specifically embraced are monohaloalkyl, dihaloalkyl and polyhaloalkyl radicals . A monohaloalkyl radical, for one example, may have either an iodo, bromo, chloro or fluoro atom within the radical. Dihalo and polyhaloalkyl radicals may have two or more of the same halo atoms or a combination of different halo radicals. "Lower haloalkyl" embraces radicals having 1-6 carbon atoms. Examples of haloalkyl radicals include fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl and dichloropropyl. The term "hydroxyalkyl" embraces linear or branched alkyl radicals having one to about ten carbon atoms any one of which may be substituted with one or more hydroxyl radicals. More preferred hydroxyalkyl radicals are "lower hydroxyalkyl" radicals having one to six carbon atoms and one or more hydroxyl radicals . Examples of such radicals include hydroxymethyl, hydroxyethyl, hydroxypropyl, hydroxybutyl and hydroxyhexyl. The terms "alkoxy" and "alkoxyalkyl" embrace linear or branched oxy-containing radicals each having alkyl portions of one to about ten carbon atoms. More preferred alkoxy radicals are "lower alkoxy" radicals having one to six carbon atoms. Examples of such radicals include methoxy, ethoxy, propoxy, butoxy and tert-butoxy. The term "alkoxyalkyl" embraces alkyl radicals having one or more alkoxy radicals attached to the alkyl radical, that is, to form monoalkoxyalkyl and dialkoxyalkyl radicals. More preferred alkoxyalkyl radicals are "lower alkoxyalkyl" radicals having one to six carbon atoms and one or two alkoxy radicals. Examples of such radicals include methoxymethyl, methoxyethyl, ethoxyethyl, methoxybutyl and methoxypropyl . The "alkoxy" or "alkoxyalkyl" radicals may be further substituted with one or more halo atoms, such as fluoro, chloro or bromo, to provide "haloalkoxy" or haloalkoxyalkyl radicals. More preferred haloalkoxy radicals are "lower haloalkoxy" radicals having one to six carbon atoms and one or more halo radicals . Examples of such radicals include fluoromethoxy, chloromethoxy, trifluoromethoxy, trifluoroethoxy, fluoroethoxy and fluoropropoxy. The term "cycloalkyl" embraces saturated carbocyclic radicals having three to twelve carbon atoms. More preferred cycloalkyl radicals are "lower cycloalkyl" radicals having three to about eight carbon atoms. Examples of such radicals include cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. The term "cycloalkenyl" embraces unsaturated cyclic radicals having three to ten carbon atoms . More preferred cycloalkenyl radicals are "lower cycloalkenyl" radicals having about five to about eight carbon atoms. Examples of such radicals include cyclobutenyl, cyclopentenyl, cyclohexenyl and cycloheptenyl . The term "aryl", alone or in combination, means a carbocyclic aromatic system containing one, two or three rings wherein such rings may be attached together in a pendent manner or may be fused. The term "aryl" embraces aromatic radicals such as phenyl, naphthyl, tetrahydronaphthyl, indane and biphenyl. Such aryl radicals may be substituted at a substitutable position with one or more substituents selected from halo, alkylthio, alkylsulfinyl, alkyl, cyano, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl and haloalkoxy. The terms "heterocyclic" and "heterocycio" embraces saturated, partially saturated and unsaturated heteroatom-containing ring-shaped radicals, where the heteroatoms may be selected from nitrogen, sulfur and oxygen. Examples of saturated heterocyclic radicals include saturated 3 to 6-membered heteromonocylic group containing 1 to 4 nitrogen atoms [e.g. pyrrolidinyl, imidazolidinyl, piperidino, piperazinyl, etc.]; saturated 3 to 6-membered heteromonocyclic group containing 1 to 2 oxygen atoms and 1 to 3 nitrogen atoms [e.g. morpholinyl, etc.]; saturated 3 to 6- membered heteromonocyclic group containing 1 to 2 sulfur atoms and 1 to 3 nitrogen atoms [e.g., thiazolidinyl, etc.] . Examples of partially saturated heterocyclic radicals include dihydrothiophene, dihydropyran, dihydrofuran and dihydrothiazole. The term "heteroaryl" embraces unsaturated heterocyclic radicals. Examples of unsaturated heterocyclic radicals, also termed "heteroaryl" radicals include unsaturated 3 to 6 membered heteromonocyclic group containing 1 to 4 nitrogen atoms, for example, pyrrolyl, pyrrolinyl, imidazolyl, pyrazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, triazolyl [e.g., 4H-1,2,4-triazolyl, 1H- 1,2, 3-triazolyl, 2H-1,2, 3-triazolyl, etc.] tetrazolyl [e.g. lH-tetrazolyl, 2H-tetrazolyl, etc.], etc.; unsaturated condensed heterocyclic group containing 1 to 5 nitrogen atoms, for example, indolyl, isoindolyl, indolizinyl, benzimidazolyl, quinolyl, isoquinolyl, indazolyl, benzotriazolyl, tetrazolopyridazinyl [e.g., tetrazolofl, 5-b]pyridazinyl, etc.], etc.; unsaturated 3 to 6-membered heteromonocyclic group containing an oxygen atom, for example, pyranyl, 2-furyl, 3-furyl, etc.; unsaturated 3 to 6-membered heteromonocyclic group containing a sulfur atom, for example, 2-thienyl, 3-thienyl, etc.; unsaturated 3- to 6-membered heteromonocyclic group containing 1 to 2 oxygen atoms and 1 to 3 nitrogen atoms, for example, oxazolyl, isoxazolyl, oxadiazolyl [e.g., 1,2,4-oxadiazolyl, 1, 3,4-oxadiazolyl, 1,2, 5-oxadiazolyl, etc.] etc.; unsaturated condensed heterocyclic group containing 1 to 2 oxygen atoms and 1 to 3 nitrogen atoms [e.g. benzoxazolyl, benzoxadiazolyl, etc.]; unsaturated 3 to 6-membered heteromonocyclic group containing 1 to 2 sulfur atoms and 1 to 3 nitrogen atoms, for example, thiazolyl, thiadiazolyl [e.g., 1,2,4- thiadiazolyl, 1, 3, 4-thiadiazolyl, 1,2, 5-thiadiazolyl, etc.] etc.; unsaturated condensed heterocyclic group containing 1 to 2 sulfur atoms and 1 to 3 nitrogen atoms [e.g., benzothiazolyl, benzothiadiazolyl, etc.] and the like. The term also embraces radicals where heterocyclic radicals are fused with aryl radicals. Examples of such fused bicyclic radicals include benzofuran, benzothiophene, and the like. Said "heterocyclic group" may be substituted at a substitutable position with one or more substituents selected from halo, alkylthio, alkylsulfinyl, alkyl, cyano, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl and haloalkoxy. More preferred heteroaryl radicals include five to six membered heteroaryl radicals. The term "heterocycloalkyl" embraces heterocyclic-substituted alkyl radicals. More preferred heterocycloalkyl radicals are "lower heterocycloalkyl" radicals having one to six carbon atoms and a heterocyclic radical . Examples include such radicals as pyrrolidinyImethyl. The term "alkylthio" embraces radicals containing a linear or branched alkyl radical, of one to about ten carbon atoms attached to a divalent sulfur atom. More preferred alkylthio radicals are "lower alkylthio" radicals having alkyl radicals of one to six carbon atoms. Examples of such lower alkylthio radicals are methylthio, ethylthio, propylthio, butylthio and hexylthio. The term "alkylsulfinyl" embraces radicals containing a linear or branched alkyl radical, of one to ten carbon atoms, attached to a divalent -S(=0)- radical . More preferred alkylsulfinyl radicals are "lower alkylsulfinyl" radicals having one to six carbon atoms. Examples of such lower alkylsulfinyl radicals include methylsulfinyl, ethylsulfinyl, butylsulfinyl and hexylsulfinyl . The term "sulfonyl", whether used alone or linked to other terms such as alkylsulfonyl, denotes respectively divalent radicals -S0 2 -. "Alkylsulfonyl" embraces alkyl radicals attached to a sulfonyl radical, where alkyl is defined as above. More preferred alkylsulfonyl radicals are "lower alkylsulfonyl" radicals having one to six carbon atoms. Examples of such lower alkylsulfonyl radicals include methylsulfonyl, ethylsulfonyl and propylsulfonyl. The "alkylsulfonyl" radicals may be further substituted with one or more halo atoms, such as fluoro, chloro or bromo, to provide "haloalkylsulfonyl" radicals. More preferred haloalkylsulfonyl radicals are "lower haloalkylsulfonyl" radicals having one or more halo atoms attached to lower alkylsulfonyl radicals as described above. Examples of such lower haloalkylsulfonyl radicals include fluoromethylsulfonyl, trifluoromethylsulfonyl and chloromethylsulfonyl. The terms "sulfamyl", "aminosulfonyl" and "sulfonamidyl" denotes NH 2 O 2 S-. The term "acyl" denotes a radical provided by the residue after removal of hydroxyl from an organic acid. Examples of such acyl radicals include alkanoyl and aroyl radicals. The terms "carboxy" or "carboxyl", whether used alone or with other terms, such as "carboxyalkyl", denotes -C0 2 H. The term "carbonyl", whether used alone or with other terms, such as "alkoxycarbonyl", denotes -(C=0)-. The term "alkoxycarbonyl" means a radical containing an alkoxy radical, as defined above, attached via an oxygen atom to a carbonyl radical. Preferably, "lower alkoxycarbonyl" embraces alkoxy radicals having one to six carbon atoms. Examples of such "lower alkoxycarbonyl" ester radicals include substituted or unsubstituted methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, butoxycarbonyl and hexyloxycarbonyl . The term "alkoxycarbonylalkyl" embraces radicals having "alkoxycarbonyl", as defined above substituted to an alkyl radical. The term "carboxyalkyl" embraces carboxylic acids attached to an alkyl radical so as to have a free acid remaining. The alkanoyl radicals may be a substituted or unsubstituted one such as formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, pivaloyl, hexanoyl, trifluoroacetyl or the like, in which the preferable one is formyl, acetyl, propionyl or trifluoroacetyl. The "aroyl" radicals may be benzoyl, naphthoyl, toluoyl, di ( tert-butyl)benzoyl and the like and the aryl in said aroyl may be additionally substituted. The term "aralkyl" embraces aryl-substituted alkyl radicals. Preferable aralkyl radicals are "lower aralkyl" radicals having aryl radicals attached to alkyl radicals having one to six carbon atoms. Examples of such radicals include benzyl, diphenyImethyl, triphenyImethyl, phenylethyl and diphenylethyl. The aryl in said aralkyl may be substituted at a substitutable position with one or more substituents selected from halo, alkylthio, alkylsulfinyl, alkyl, cyano, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl and haloalkoxy. The terms benzyl and phenyImethyl are interchangeable. The term "aryloxy" •embrace oxy-containing aryl radicals attached through an oxygen atom to other radicals. More preferred aryloxy radicals are "lower aryloxy" radicals having a phenyl radical. An example of such radicals is phenoxy. The term "aryloxyalkyl" embraces alkyl radicals having one or more aryloxy radicals attached to the alkyl radical, that is, to form monoaryloxyalkyl and diaryloxyalkyl radicals. The "aryloxy" or "aryloxyalkyl" radicals may be further substituted at a substitutable position with one or more alkyl, alkoxy or halo radicals. to provide haloaryloxyalkyl radicals alkylaryloxy radicals, and the like. Examples of such radicals include chlorophenoxy and methylphenoxy. The term "aralkyloxy" embrace oxy-containing aralkyl radicals attached through an oxygen atom to other radicals. The term "aralkyloxyalkyl" embraces alkyl radicals having one or more aralkyloxy radicals attached to the alkyl radical, that is, to form monoaralkyloxyalkyl and diaralkyloxyalkyl radicals. The "aralkyloxy" or "aralkyloxyalkyl" radicals may be further substituted on the aryl ring portion of the radical. The term "aminoalkyl" embraces alkyl radicals substituted with amino radicals. More preferred aminoalkyl radicals are "lower aminoalkyl" having one to six carbon atoms. Examples include aminomethyl, aminoethyl and aminobutyl. The term "alkylaminoalkyl" embraces aminoalkyl radicals having the nitrogen atom substituted with at least one alkyl radical. More preferred alkylaminoalkyl radicals are "lower alkylaminoalkyl" having one to six carbon atoms attached to a lower aminoalkyl radical as described above. The term "alkylamino" denotes amino groups which have been substituted with one or two alkyl radicals. More preferred alkylamino radicals are "lower alkylamino" radicals having one or two alkyl radicals of one to six carbon atoms, attached to a nitrogen atom. Suitable "alkylamino" may be mono or dialkylamino such as N-methylamino, N-ethylamino, N,N- dimethylamino, N,N-diethylamino or the like. The term "arylamino" denotes amino groups which have been substituted with one or two aryl radicals, such as N- phenylamino. Arylamino radicals may be substituted at a substitutable position with one or more alkyl, cyano, alkoxy, alkoxycarbonyl or halo radicals. The term "aralkylammo" denotes amino groups which have been substituted with one or two aralkyl radicals, such as N-benzylamino, N-phenethylamino and phenpropylamino. The "aralkylammo" or "arylamino" radicals may be further substituted on the aryl ring portion of the radical. The term "aminocarbonyl", whether used by itself or with other terms such as "N- alkylaminocarbonyl" , "N-arylaminocarbonyl" , "N,N- dialkylaminocarbonyl" and "N-alkyl-N- arylaminocarbonyl" , denotes a radical formed by an amino substituted carbonyl, or -C(=0)NH 2 . The term "alkylaminocarbonyl" embraces "N-alkylaminocarbonyl" and "N,N-dialkylaminocarbonyl" , which denotes aminocarbonyl groups which have been substituted with one alkyl radical and with two alkyl radicals, respectively. The N-alkylaminocarbonyl may be substituted with halo or an unsubstituted one such as N-methylaminocarbonyl, N-ethylaminocarbonyl, N- propy1aminocarbonyl, N,N-dimethylaminocarbonyl, 2,2,2- trifluoroethylaminocarbonyl or the like. The terms "N- monoarylaminocarbonyl" and "N-alkyl-N- arylammocarbonyl" denote amido radicals substituted, respectively, with one aryl radical, and one alkyl and one aryl radical. The N-arylaminocarbonyl may be phenylaminocarbonyl, naphthylaminocarbonyl, tolylaminocarbonyl, xylylaminocarbonyl, mesitylammocarbonyl, cumenylammocarbonyl, and the like, in which the preferable one is phenylaminocarbonyl. The term "alkylsulfonylamino" embraces radicals having an alkylsulfonyl radical attached to a nitrogen atom. More preferred are "lower alkylsulfonylamino" having alkylsulfonyl radicals of one to six carbon atoms attached to the nitrogen. The terms "heteroarylsulfonylaikyl" and "heteroarylsulfonylhaloalkyl" denotes heteroaryl radicals attached through a sulfonyl bridging group to an alkyl radical or haloalkyl radical, respectively. More preferred heteroarylsulfonylaikyl and heteroarylsulfonylhaloalkyl radicals are "lower heteroarylsulfonylaikyl" and "lower heteroarylsulfonylhaloalkyl" radicals where the alkyl and haloalkyl portions have 1 to 6 carbon atoms. Examples of such radicals include thienylsulfonyImethyl, and thienylsulfonylbromomethyl. The present invention comprises a pharmaceutical composition comprising a therapeutically-effective amount of a compound of Formula I in association with at least one pharmaceutically-acceptable carrier, adjuvant or diluent. The present invention also comprises a method of treating inflammation or inflammation-associated disorders in a subject, the method comprising administering to the subject having or susceptible to such inflammation or disorder, a therapeutically- effective amount of a compound of Formula I. Also included in the family of compounds of Formula I are the pharmaceutically-acceptable salts thereof. The term "pharmaceutically-acceptable salts" embraces salts commonly used to form alkali metal salts and to form addition salts of free acids or free bases. The nature of the salt is not critical, provided that it is pharmaceutically-acceptable. Suitable pharmaceutically- acceptable acid addition salts of compounds of Formula I may be prepared from an inorganic acid or from an organic acid. Examples of such inorganic acids are hydrochloric, hydrobromic, hydroiodic, nitric, carbonic, sulfuric and phosphoric acid. Appropriate organic acids may be selected from aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic, carboxylic and sulfonic classes of organic acids, example of which are formic, acetic, propionic, succinic, glycolic, gluconic, lactic, malic, tartaric, citric, ascorbic, glucuronic, maleic, fumaric, pyruvic, aspartic, glutamic, benzoic, anthranilic, mesylic, salicylic, p-hydroxybenzoic, phenylacetic, mandelic, embonic (pamoic) , methanesulfonic, ethylsulfonic, benzenesulfonic, pantothenic, toluenesulfonic, 2-hydroxyethanesuIfonic, sulfanilic, stearic, cyclohexylaminosulfonic, algenic, β-hydroxybutyric, salicylic, galactaric and galacturonic acid. Suitable pharmaceutically-acceptable base addition salts of compounds of Formula I include metallic salts made from aluminum, calcium, lithium, magnesium, potassium, sodium and zinc or organic salts made from N,N' -dibenzylethylenediamine, chloroprocaine, choline, diethanolamine, ethylenediamine, meglumine (N- methylglucamine) and procaine. All of these salts may be prepared by conventional means from the corresponding compound of Formula I by reacting, for example, the appropriate acid or base with the compound of Formula I. . GENERAL SYNTHETIC PROCEDURES The compounds of the invention can be synthesized according to the following procedures of Schemes I-X, wherein the RI-R^ substituents are as defined for Formulas I-IV, above, except where further noted. SCHEME I Synthetic Scheme I shows the procedure used to prepare the antiinflammatory substituted thiazoles 3 of the present invention from α-haloketones 1. The α- haloketones 1, such as 2-bromo-ethanone, are reacted with a thioamide 2 or thiourea in acetonitrile and an alcohol, such as methanol and ethanol, to give the 4,5- substituted thiazoles 3 via the Hantzsch synthesis (R. Wiley et al, The Preparation of Thiazoles. ORGANIC REACTIONS, VOLUME 6, (1951)). SCHEME II DPPA, Et 3 N, Ph-CH 3 , 0°C - Δ 2. t-BuOH, HCI, RT- Δ Synthetic Scheme II shows the four step procedure which can be used to prepare the substituted ketone compounds 7 from aldehyde 4 and acid 5. In step one, aldehyde 4 and substituted acetic acid 5 are heated in acetic anhydride and triethylamine to form the 2,3- disubstituted acrylic acids 6 via a Perkin condensation. In step two, the addition of water produces the corresponding 2 ,3-disubstituted acrylic acids 6. In step three, the acrylic acids 6 are reacted with diphenylphosphorylazide (DPPA) and triethylamine in toluene at 0°C and then at room temperature to form acylazides. In step four, the crude acylazides are heated to form an isocyanate via a Curtius rearrangement. The isocyanate is trapped as the N-tert-butyloxycarbonyl enamine derivative via the addition of tert-butanol. Acidic hydrolysis using concentrated HCI provides the substituted ketone 7 intermediates. SCHEME III X=C1 , Br , F , OH Synthetic Scheme III shows an alternative approach which can be used to prepare the substituted ketone intermediates 7 via the use of Friedel Crafts acylation. An acylating agent 8, such as an acid chloride is treated with aluminum chloride in an inert solvent, such as methylene chloride, chloroform, nitrobenzene, dichlorobenzene or chlorobenzene, and reacted with R 2 to form ketone 7. Other synthetic approaches are possible to form the desired ketones. These alternatives include reacting appropriate Grignard or lithium reagents with substituted acetic acids or corresponding esters. SCHEME IV Synthetic Scheme IV shows the procedure which can be used to prepare the substituted haloketone compounds 1. 1, 2-Disubstituted ketone intermediates 7 from Synthetic Schemes II or II are readily brominated via the addition of bromine in acetic acid to form the 2- bromo-1, 2-disubstituted ethanone intermediates 1. Alternative means of forming 2-haloketones 1 include the conversion of benzoins such as substituted 2-hydroxyethanones via use of reagents such as thionyl chloride, sulf ryl chloride, methylsulfonyl chloride/lithium chloride, triphenylphosphine dichloride or triphenylphosphine dibromide, among others. The conversion of simple desoxybenzions to the haloketones 1 is readily accomplished via use of halogenating reagents such as bromine, N- bromosuccinimide, N-chlorosuccinimide. SCHEME V 2 Synthetic Scheme V shows a procedure for the preparation of thioamides 2 by the thiation of the oxygen carboxamide 9 counterparts. The carboxamide 9 is dissolved in a solvent, such as diethyl ether, and cooled to about 0°C. The thiation reagent, such as phosphorous pentasulfide (P 2 S 5 or P 4 S 10 ) is added and maintained at a temperature below room temperature. The reaction is warmed to room temperature and stirred. The ethereal solution of the thioamide 2 can be decanted from the reaction mixture and used "as is". Alternative means of forming the thioamides 2 includes the use of 2, 4-bis (4-methoxyphenyl) -1, 3- dithia-2, 4-diphosphetane-2, 4-disulfide (Lawesson's Reagent) as the thiation reagent. The reaction is heated at reflux. In addition, thioamides 2 can be formed by the reaction of a suitable nitrile with hydrogen sulfide. SCHEME VI 12 Synthetic Scheme VI shows a three step procedure which can be used to prepare alkylsulfonyl substituted thiazoles 12 from alkylthio substituted ketones 10. In step one, the alkylthioether of ethanone 10, where the thioether radical is located at R 3 and R 4 is an alkyl radical, is first oxidized to an alkylsulfone using jneta-chloroperoxybenzoic acid (MCPBA) (2 eq) in methylene chloride at 0°C and warmed to room temperature. In step two, the alkylsulfonylketone, where the alkylsulfone radical is located at R 3 , is brominated alpha to the carbonyl using bromine in HBr/HOAc to form the alkylsulfonyl-2-bromoethanone 11. Condensation of 11 with an appropriate thioamide or thiourea 2 provides the corresponding substituted 5- (4-alkylsulfonylphenyl)thiazole 12. Alternatively, the procedure can be utilized to produce thiazoles having an alkylsulfonyl radical at R 2 . SCHEME VII 13 12 An alternative synthesis of the alkylsulfonyl substituted thiazoles 12 is accomplished as shown in Synthetic Scheme VII. Thiazole 13, having an alkylthiophenyl radical at R-^ where R is an alkyl radical, is oxidized with MCPBA (2 equivalents) in methylene chloride to form the alkylsulfone 12. Other suitable oxidizing agents include Oxone®, hydrogen peroxide, periodate, peracetic acid and the like. Alternatively, the procedure can be utilized to produce thiazoles having an alkylsulfonylphenyl radical at R 2 . Scheme VIII o II 1 . Base , THF , - 78°C ^ Ar— S-CH 3 Ar — S- H 2 II 2 . B ( R) 3 , Δ o o II 3 . H 2 NOS0 3 H , 14 NaOAc , H 2 0 15 °C λr- S-CH 2 F O II 16 Synthetic Scheme VIII shows the three step procedure used to prepare sulfonamide antiinflammatory agents 15 and the two step procedure used to prepare fluoromethyl sulfone antiinflammatory agents 16 from their corresponding methyl sulfones 14. In step one, a THF solution of the methyl sulfones 14 at -78°C is treated with an alkyllithium or organomagnesium (Grignard) reagent (RMgX) , e.g., methyllithium, n- butyllithium, etc. In step two, the anions generated in step one are treated with an organoborane, e.g., triethylborane, tributylborane, etc., at -78°C then warmed to ambient temperature prior to stirring at reflux. An alternative to the boron chemistry involves room temperature alkylation, such as with trimethylsilylmethylhalides, followed by treatment with tetrabutylammonium fluoride (1M in THF) . In step three, an aqueous solution of sodium acetate and hydroxyamine- O-sulfonic acid is added to provide the corresponding sulfonamide antiinflammatory agents 15 of this invention. Alternatively, the anion solutions generated in step one may be warmed to 0°C and treated with N-fluorodibenzenesulfonamide to provide the corresponding fluoromethyl sulfone antiinflammatory agents 16 of this invention. Scheme IX Synthetic Scheme IX shows the four step procedure used to prepare sulfonamide antiinflammatory agents 23 of the present invention. Synthesis of deoxybenzoin intermediates can be accomplished via condensation of an appropriate "benzylate" anion with an appropriate ester. As shown in Scheme IX, phenylacetonitrile 17 upon deprotonation with an appropriate base (eg. sodium methoxide, sodium hydride, lithium diisopropyl amide, etc.), will react with an appropriate ester 18 to form an α-cyanoketone. Acid catalyzed hydrolysis of the nitrile and subsequent decarboxylation yield the ketone intermediate 19. Chlorosulfonation of the ketone 19) will yield a sulfonyl chloride intermediate which reacts readily with ammonia (eg. NH4OH) to yield the p- benzenesulfonamide derivative 20. Bromination of this ketone 20 with Br2 using HBr as catalyst yields the corresponding alpha-bromoketone 21. This bromoketone can be condensed with thioamides and thioureas 22 in the Hantzsch reaction to form the thiazole nucleus 23. Scheme X 14 25 Alternatively, the sulfonamide moiety can be introduced after the thiazole ring has already been formed. Treatment of an appropriately substituted phenyl-thiazole 24 with neat chlorosulfonic acid followed by reaction with ammonia yields the corresponding (5-thiazolyl)benezenesulfonamide 25. The other regioisomer, (4-thiazolyl)benezenesulfonamide, can be prepared depending on the R^ substituent. For example, if the phenyl radical at position 5 is substituted at the para position. The following examples contain detailed descriptions of the methods of preparation of compounds of Formula I-IV. These detailed descriptions fall within the scope, and serve to exemplify, the above described General Synthetic Procedures which form part of the invention. These detailed descriptions are presented for illustrative purposes only and are not intended as a restriction on the scope of the invention. All parts are by weight and temperatures are in Degrees centigrade unless otherwise indicated. Example 1 2- ( (4-Chlorophenoxvιmethvl i -4- (4-fluorophenyl ) - 5- (4-methylsulfonvlphenvl i thiazole Step 1 Preparation of 2- (4-fluorophenyl) -3- (4- methvlthiophenvDpropenoic acid: Acetic anhydride (500 mL) , 4- (methylthio)benzaldehyde (100.2 g, 0.66 mol), 4- fluorophenylacetic acid (101.6 g, 0.66 mol), and triethylamine (68.1 g, 0.67 mol) were heated to reflux for 1.75 hours. The reaction was cooled to 110°C, and water (500 mL) was added cautiously. This caused the solution to reflux vigorously and the temperature to rise to 135°C. A yellow precipitate formed, and after cooling to room temperature, was collected by filtration, washed with water, and recrystallized from ethyl acetate/isooctane to provide the diarylpropenoic acid as yellow needles (135.2 g, 71%): mp 172-176°C. lH NMR (acetone-d 6 ) 6300 MHz 7.84 (s, IH) , 7.03-7.28 (m, 10H) , 2.46 (s, 3H) ; "F NMR (acetone-d 6 ) -116.11 (m) . Mass spectrum: M+ 288. s ep 2: Preparation of i-^-fluorophenyl)-2-(4- mef.hvlthiophenvl)ethanone: The diarylpropenoic acid from Step 1 (226.5 g, 0.78 mol) was added to anhydrous toluene (800 mL) and triethylamine (81.2 g, 0.80 mol). After cooling to 0°C, diphenylphosphoryl azide (217.4 g, 0.79 mol) was added. The solution was stirred at 0°C for twenty minutes and at room temperature for 2.5 hours. The reaction was poured into water, extracted with ether, dried over magnesium sulfate, and concentrated in vacuo to remove the ether. The remaining toluene solution was heated to reflux and a vigorous evolution of gas occurred. After 1.25 hours, tert-butyl alcohol (80 mL, 0.84 mol) was added to the reaction. After an additional twenty minutes, concentrated hydrochloric acid (41 mL) was added slowly causing the reaction to foam. The reaction was heated at 90°C overnight (14 hours) and after cooling, a white precipitate formed. The precipitate was isolated by filtration, washed with cold ether, and air dried to yield the desired ketone (182.7 g, 89%) : mp 134.5-138°C. lH NMR (acetone-d δ ) 300 MHz 8.16 (m, 2H) , 7.24 (m, 6H) , 4.34 (s, 2H) , 2.46 (s, 3H) ; 19 F NMR (acetone-dε) -107.88 (m) . Step 3: Preparation of 1- (4-fluoronhenvl ) -2- (4- methvlthiophenvl) -2-bromoethanone: The ketone from Step 2 (55.5 g, 0.21 mol) was added to acetic acid (250 mL) and 33% HBr in acetic acid (120 mL) . The solution was stirred and treated with bromine (11.1 mL, 0.21 mol) at such a rate that the bromine color was discharged rapidly, ca. 15 minutes. After an additional 10 minutes at room temperature, the solution was filtered and the filtrate concentrated in vacuo to give the bromoketone as an orange solid. The crude bromoketone was dissolved in dichloromethane and washed with IN NaHS0 3 , dried over anhydrous MgS0 4 , filtered and concentrated in vacuo to give 68.8 g of l-(4- fluorophenyl) -2- (4-methylthiophenyl) -2-bromoethanone as a yellow solid which was used directly in the next step. Step 4: Preparation of 2- ( (4-chlorophenoxy)methv] ) -4- (4-fluorophenyl) -5- (4-methvlthiophenvl) hiazole: A solution of the bromoketone from Step 3 (2.51 g, 7.4 mmol) and 4-chlorophenoxy thioacetamide (1.27 g, 7.3 mmol) in 25 mL of acetonitrile was heated to reflux for 4 hours and concentrated in vacuo. the residue was taken up in ethyl acetate and washed successively with sat. aq. NaHC0 3 , brine, dried over anhydrous MgS0 4 , filtered and concentrated in vacuo to give the crude thiazole. The thiazole was purified by flash chromatography on silica gel, eluting with 5% ethyl acetate in hexane. The appropriate fractions were combined, concentrated in vacuo and then the crude solid was recrystallized from methanol to give pure thiazole (1.71 g, 61%) : mp 91-95°C. J-H NMR (CDCI 3 ) 300 MHz 7.49 (m, 2H) , 7.22 (m, 6H) , 6.99 (m, 4H) , 5.37 (s, 2H) , 2.49 (s, 3H) ; 19 F NMR (CDCI 3 ) -113.53 (m) . High resolution field desorption mass spectrum Calc'd. for C 23 Hi 7 ClFNOS 2 Li (M++Li) : 448.0584. Found: 448.0554. Step 5: Preparation of 2- ( (4-chlorophenoxy)methvl) -4- ( -fluorophenyl) -5- ( -methylsulfonvlnhenvl) thiazole: A solution of the thiazole from Step 4 (1.39 g, 3.1 mmol) in 20 mL of dichloromethane was treated with m-chloroperbenzoic acid (MCPBA) (2.22 g, 6.4 mmol) at 0°C for 1 hour. The solution was washed with 10% aq. NaHSθ 3 , 10% a2Cθ 3 , dried over anhydrous M S0 4 , filtered and concentrated in vacuo to give a white foam that was purified by recrystallization from a mixture of dichloromethane and isooctane to give pure product (1.24 g, 83%) : mp 140-43°C. lH NMR (CDC1 3 ) 300 MHz 7.87 (d, J= 8.5Hz, 2H) , 7.53 (d, J=8.5Hz, 2H) , 7.45 (m, 2H) , 7.27 (d, J=9.2Hz, 2H) , 6.99 (m, 4H) , 5.38 (s, 2H) , 3.08 (s, 3H) ; 19 F NMR (CDCI3) -112.40 (m) . Mass spectrum: M+H = 474. Example 2 2- (2-Chlorophenyl) -4-phenyl-5- (4- methylsulfonylphenyl )thiazole Step 1: Preparation of 2-phenvl-3- (4- methvlf.hiophenvDpropenoiπ acid: A mixture of acetic anhydride (500 mL) , 4- (methylthio)benzaldehyde (113.1 g, 0.743 mol), phenylacetic acid (101.2 g, 0.743 mol), and triethylamine (75.8 g, 0.75 mol) was heated to reflux for 5 hours. The reaction was cooled to 110°C, and water (500 mL) was added. A yellow precipitate formed, and after further cooling to room temperature, the solid was collected by filtration, washed with water, and recrystallized from isopropyl alcohol to give the diarylpropenoic acid as white needles (94.2 g, 57%): mp 167-169°C. lH NMR (CDC1 3 ) 5300 MHz 12.00 (br s, IH) , 7.91 (s, IH) , 7.38 (m, 3H) , 7.24 (m, 2H) , 7.00 (d, 2H) , 6.99 (d, 2H) , 2.43 (s, 3H) . Step 2: Preparation of 2- (4-methvlthiophenvl) -1- phenylethanone; The diarylpropenoic acid from Step 1 (12.27 g, 45.4 mmol) and triethylamine (8.44 g, 84 mmol) were dissolved in 110 mL of anhydrous toluene, cooled to 0°C and treated with diphenylphosphoryl azide (12.6 g, 83.4 mmol) . The solution was maintained at 0°C for twenty minutes and warmed to room temperature for 2.5 hours. The reaction was poured into water, extracted with ether, dried over magnesium sulfate, and concentrated in vacuo to remove the ether. The remaining toluene solution was heated to reflux for 1.25 hours. tert-Butyl alcohol (5 mL, 53 mmol) was added to the solution, after an additional twenty minutes, concentrated hydrochloric acid (4 mL) was cautiously added and the reaction maintained at 90°C overnight (14 hours) . After cooling the solution to room temperature, a white precipitate formed which was isolated by filtration, washed with cold ether, and air dried to yield the desired ketone which was crystallized from a mixture of dichloromethane and isooctane (5.16 g, 47%): mp 123-127°C. lH NMR (CDCI 3 ) 300 MHz 7.99 (d, J=7.3Hz, 2H) , 7.56 (m, IH) , 7.46 (m, 2H) , 7.22 (d, J=8.4Hz 2H) , 7.20 (d, J=8.5Hz, 2H) , 4.24 (s, 2H) , 2.46 (s, 3H) . Step : Preparation of 2-bromo-2- (4-me hvl hionhenvl) - 1-phenvlethanone: A solution of the ketone from Step 2 (2.35 g, 9.7 mmol) in acetic acid (50 mL) and 33% HBr in acetic acid (4 mL) was treated with a 1.1 M solution of bromine in acetic acid (9 mL, 9.9 mmol) and then stirred at room temperature for 1 hour. The solution was diluted with dichloromethane and washed with IN NaHS0 3 , dried over anhydrous MgS0 4 , filtered and concentrated in vacuo to give the bromoketone which was used directly in the next step (2.38 g, 76%) : mp 93-95°C. IH NMR (CDCI3) 300 MHz 7.97 (d, J=7.3Hz, 2H) , 7.57 (m, IH) , 7.46 ( , 4H) , 7.24 (d, J=8.5Hz, 2H) , 6.35 (s, IH) , 2.47 (s, 3H) . Step 4: Preparation of 2- (2-chlorophenyl) -4-phenvl-5- (4-methvlthiophenvl) thiazole: A solution of the bromoketone from Step 3 (2.38 g, 7.4 mmol) and 4-chlorothiobenzamide (1.29 g, 7.5 mmol) in 25 mL of acetonitrile was heated to reflux for 14 hours. The solution was cooled to room temperature and poured into 25 mL of methanol whereupon crystals of pure diaryl thiazole formed which were isolated by filtration and air dried to afford the pure diaryl thiazole (2.01 g, 69%) : mp 107- 109.5°C. lH NMR (CDCI3) 300 MHz 8.37 (m, IH) , 7.62 (m, 2H) , 7.49 (d, J=7.7Hz, IH) , 7.32 (m, 7H) , 7.22 (d, J=8.5Hz, 2H) , 2.51 (s, 3H) . Mass spectrum M+H =394. Step 5: Preparation of 2- (2-chlorophenyl) -4-phenvl-5- (4-methvlsulfonvlphenvl) hiazole: A solution of the diaryl thiazole from Step 4 (1.90 g, 4.8 mmol) in 10 mL of dichloromethane was treated with MCPBA (3.40 g, 9.9 mmol) at 0°C for 1 hour. The solution was washed with 10% aq. NaHS0 3 , 10% Na2C0 3 , dried over anhydrous MgSθ 4 , filtered and concentrated in vacuo to give a yellow solid that was purified by flash chromatography on silica gel eluting with 1:1 hexane:ethyl acetate to provide 1.5 g, 73% of pure product: mp 191.5-195°C. *H NMR (CDCI 3 ) 300 MHz 8.40 (m, IH) , 7.88 (d, J=8.5Hz, 2H) , 7.51-7.62 (m, 5 H) , 7.35-7.41 (m, 5H) , 3.09 (ε, 3H) . High resolution mass spectrum Calc'd. for C22H 1 6CINO2S 2 : 425.0311. Found: 425.0315. Example 3 2- (2-Chlorophenyl) -4- (3-fluorophenyl) -5- ( methylsulfonylphenyl ) thiazole Step 1: Preparation of 2- (3-fluorophenyl) -3- (4- methvlthiophenvDpropenoic acid: A mixture of acetic anhydride (60 mL) , 4- (methylthio)benzaldehyde (4.99 g, 33 mmol), 3- fluorophenylacetic acid (5.08 g, 33 mmol), and triethylamine (3.98 g, 39 mmol) was heated to reflux for 4 hours. The reaction was cooled to 120°C, and water (120 mL) was added. A yellow precipitate formed and, after further cooling to room temperature, was collected by filtration, washed with water, and recrystallized from toluene to give the desired intermediate as a yellow solid (3.72 g, 39%): mp 184- 187°C. IH NMR (CDC1 3 ) 300 MHz 7.92 (s, IH) , 7.35 (m, IH) , 7.26 (d, J=6.3Hz, IH) , 7.19 (d, J=7.7Hz, IH) 7.00 (m, 5H) , 2.44 and 2.36 (ε, 3H) ; l°F NMR (CDCI 3 ) -112.61 (m) . Mass spectrum M+H=289. Step 2 : 'Preparation of 1- (3-fluorophenyl) -2- (4- methvlthiophenvl) thanone: A solution of the intermediate from Step 1 (3.57 g, 12.4 mmol) and triethylamine (1.41 g, 13.9 mmol) dissolved in 35 mL of anhydrous toluene was cooled to 0°C and treated with diphenylphosphoryl azide (3.53 g, 12.8 mmol) . The solution was maintained at 0°C for twenty minutes and warmed to room temperature for 3 hours. The reaction was poured into water, extracted with ether, dried over magnesium sulfate, and concentrated in vacuo to remove the ether. The remaining toluene solution was heated to reflux for 1 hour. tert-Butyl alcohol (4 mL, 42 mmol) was added to the reaction mixture. After an additional twenty minutes, concentrated hydrochloric acid (4 mL) was cautiously added and the reaction maintained at 80°C overnight (14 hours) » After cooling the solution to room' temperature, the mixture was poured into a separator/ funnel and washed with water. The toluene layer was dried with anhydrous MgS0 4 , filtered and concentrated in vacuo to give a yellow powder. The crude solid was crystallized from a mixture of dichloromethane and isooctane to provide 1.30 g (40%) of the desired ketone: mp 116-120°C. lH NMR (CDCI 3 ) 300 MHz 7.77 (d, J=7.9 Hz, IH) , 7.68 (dt, J=9.4Hz 2.6Hz, IH) , 7.43 (m, IH) , 7.21-7.29 (m, 3H) , 7.18 (d, J=8.3Hz, 2H) , 4.22 (s, 2H) , 2.46 (s, 3H) ; "F NMR (CDCI 3 ) -111.82 (m) . Mass spectrum M+H=261. Step 3: Preparation of 2-bromo-l- (3-flnoroohenvl) - (4- me hvlthiophenvl) ethanone: A solution of the ketone from Step 2 (1.53 g, 5.9 mmol) in acetic acid (20 mL) and 33% HBr in acetic acid (0.5 mL) was treated with a 0.99 M solution of bromine in acetic acid (6.1 mL, 6.0 mmol) and stirred at room temperature for twenty minutes. The contents of the flask solidified and the precipitate was isolated by filtration. The filtrate solution was diluted with dichloromethane and washed with IN NaHS0 3 , dried over anhydrous MgS0 4 , filtered and concentrated in vacuo to give a solid that was combined with the original precipitate to provide 1.92 g (96%) of bromoketone: mp 101-104°C. lH NMR (CDCI 3 ) 300 MHz 7.73 (d, J=7.9Hz, IH) , 7.67 (dt, J=9.4Hz 2.3Hz, IH) , 7.41 (m, 3H) , 7.24 (m, 3H) , 6.27 (s, IH) , 2.47 (s, 3H) ; l^F NMR (CDCI 3 ) -111.18 (m) . Mass spectrum: M+H =340. Step 4: Preparation of 2- (2-chlorophenv -4- (3- fluorophenyl) -5- (4-methvlthiophenvl)thiazol : A solution of the bromoketone intermediate from Step 3 (0.77 g, 2.3 mmol) and 4-chlorothiobenzamide (0.40 g, 2.3 mmol) in 10 mL of acetonitrile was heated to reflux for 4 hours. The solution was cooled to room temperature and poured into 25 mL of methanol whereupon crystals of thiazole formed which were isolated by filtration and air dried to afford the pure thiazole (0.66 g, 71%) : mp 106.5-108°C. iH NMR (CDCI 3 ) 300 MHz 8.37 (dd, J=7.4Hz 2.2Hz, IH) , 7.49 (d, J=7.0Hz, IH) , 7.21-7.42 (m, 9H) , 7.00 (t, J=8.5Hz, IH) , 2.51 (s, 3H) ; i^F NMR (CDCI 3 ) -113.10 (m) . Mass spectrum: M+=412. Step 5: Preparation of 2- (2-chlorophenyl) -4- (3- fluorophenvl)-5- (4-methylsulfonvlphenvl) thiazole: A solution of the thiazole from Step 4 (610 mg, 1.48 mmol) in 15 mL of dichloromethane was treated with MCPBA (1.05 g) at room temperature for 72 hours. The solution was washed with 10% aq. NaHS0 3 , 10% Na2C0 3 , dried over anhydrous MgSθ 4 , filtered and concentrated in vacuo to give a yellow oil that was crystallized from toluene to give yellow needles (320 mg, 48%): mp 133.5-135°C. iH NMR (CDCI 3 ) 300 MHz 8.39 (m, IH), 7.91 (d, J=8.5Hz, 2H) , 7.63 (d, J=8.5Hz 2H) , 7.51 (m, IH), 7.40 (m, 3H) , 7.28 (m, 2H) , 7.10 (m, IH) 3.10 (s, 3H) ; 1° NMR (CDCI 3 ) -112.70 (m) . Mass spectrum: M+=444. Example 4 4- (2, 4 -Dif luorophenyl) -2- ( 2 -chlorophenyl ) -5- (4- methylsulf onylphenyl ) thiazole Step 1: Preparation of 2- (2.4-dif luoroohenvl) -3- (4- methvlthiophenvDpropenoic acid: A mixture of acetic anhydride (50 mL) , 4- (methylthio)benzaldehyde (3.75 g, 24.6 mmol), 2,4- dif luorophenylacetic acid (4.41 g, 24.6 mmol), and triethylamine (2.80 g, 27.7 mmol) was heated to reflux for 3.5 hours. The reaction was cooled to 90°C, and water (100 mL) was added. A yellow oil formed that solidified upon stirring. The solid was collected by filtration, and dissolved in ethyl acetate, dried over anhydrous MgSθ 4 , filtered and concentrated in vacuo . The solid thus obtained was recrystallized from toluene to give the desired acid (3.18 g, 42%) : mp 165-171°C. iH NMR (acetone-dε) 300 MHz 7.95 (s, IH) , 7.08-7.18 (m, 7H) , 2.47 and 2.31 (s, 3H) ; 1 9 F NMR (acetone-dβ) -110.81 (m) -111.75 (m) . Mass spectrum: M+H=306. Step 2 : Preparation of 1- (2.4-difluorophenyl) -2- (4- hY thiophenyl)ethanone; A solution of the acid from Step 1 (3.11 g, 10.2 mmol) and triethylamine (1.23 g, 10.8 mmol) dissolved in 15 mL of anhydrous toluene, was cooled to 0°C and treated-with diphenylphosphoryl azide (2.98 g, 10.8 mmol) . The solution was maintained at 0°C for twenty minutes and warmed to room temperature for 1 hour. The reaction was poured into water, extracted with ether, dried over magnesium sulfate, and concentrated in vacuo to remove the ether. The remaining toluene solution was diluted with an additional 10 mL of toluene and heated to 90°C for 1.5 hours. tert-Butyl alcohol (4 mL, 42 mmol) was added to the reaction mixture. After an additional twenty minutes, concentrated hydrochloric acid (4 mL) was cautiously added and the reaction maintained at 90°C overnight (16 hours) . After cooling the solution to room temperature, the mixture was diluted with ethyl acetate, and washed with water. The organic layer was dried with anhydrous MgS0 4 , filtered and concentrated in vacuo to give a yellow solid. The crude solid was crystallized from a mixture of ethyl acetate and hexane to provide the desired ketone (2.19 g, 77%) : mp 82-88.5°C. iH NMR (CDCI3) 300 MHz 7.91 (q, J=6.0Hz, IH) , 7.22 (d, J=8.lHz, 2H) , 7.15 (d, J=8.5Hz, 2H) , 6.82-6.97 (m, 2H) , 4.21 (d, J=2.6Hz, 2H) , 2.46 (s, 3H) ; 19 F NMR (CDC1 3 ) -101.74 (m) , -104.15 (m) . Mass spectrum: M+=278 . Step : Preparation of 1- (2.4-difluorophenyl) -2-bromo- 2- f4-methvl hiophenvl)ethanon : A solution of the ketone intermediate from Step 2 (2.05 g, 7.4 mmol) in acetic acid (30 mL) and 33% HBr in acetic acid (0.5 mL) was treated with a 0.99 M solution of bromine in acetic acid (7.6 mL, 7.5 mmol) and stirred at room temperature for 1 hour. The solution was concentrated in vacuo and the residue was taken up in dichloromethane, washed with IN NaHS0 3 , brine, dried over anhydrous MgSθ 4 , filtered, and concentrated in vacuo to give a brown solid (2.39 g, 90%) that was unstable and used directly in the next step without further purification. J-H NMR (CDCI 3 ) 300 MHz 7.94 (q, J=6.3Hz, IH) , 7.37 (d, J=8.5Hz, 2H) , 7.21 (d, J=8.5Hz, 2H) , 6.97 (m, IH) , 6.84 (m, IH) , 6.28 (s, IH) , 2.46 (s, 3H) ; "F NMR (CDCI 3 ) -100.31 (m) , -103.50 (m) . Mass spectrum: M+H = 358. Step 4: Preparation of 4- (2.4-difluorophenyl) -2- (2- chlorophenvl) -5- (4-methvlthiophenvl)thiazol : A solution of the bromoketone intermediate from Step 3 (0.49 g, 1.3 mmol) and 4-chlorothiobenzamide (0.24 g, 1.4 mmol) in 5 mL of acetonitrile was heated to reflux for 3 hours. The solution was cooled to room temperature and poured into 20 mL of methanol, chilled with an ice bath, whereupon crystals of the thiazole formed which were isolated by filtration and air dried (0.31 g, 52%) : mp 103-105°C. *H NMR (CDCI 3 ) 300 MHz 8.31 (m, IH) , 7.50-7.60 (m, 2H) , 7.36 (m, 2H) , 7.23 (d, J=8.5Hz, 2H) , 7.19 (d, J=8.5Hz, 2H) , 6.94 (t, J=8.5Hz, IH) , 6.83 (t, J=9.2Hz, IH) 2.48 (s, 3H) . 19F NMR (CDCI3) -108.50 (m) , -109.49 (m) . Mass spectrum M+H=430. Step 5: Preparation of 4- (2.4-difluorophenyl) -2- (2- chlorophenvl) -5- (4-methvlsulfonvlphenvl)thiazole: A solution of the thiazole from Step 4 (260 mg, 0.60 mmol) in 4 mL of dichloromethane was treated with MCPBA (0.42 g) at room temperature for 1.5 hours. The solution was diluted with additional dichloromethane, washed with 10% aq. NaHS0 3 , 10% Na2C0 3 , dried over anhydrous MgSθ 4 , filtered and concentrated in vacuo to give a white solid that was recrystallized from a mixture of dichloromethane and isooctane to give white needles (250 mg, 89%) : mp 166-169°C. iH NMR (CDCI 3 ) 300 MHz 8.34 (m, IH) , 7.88 (d, J=8.5Hz, 2H) 7.65 (q, J=6.6Hz, IH) , 7.55 (d, J=8.lHz, 2H) , 7.41 (m, 2H) , 7.26 (s, IH) , 6.99 (t, J=8.lHz, IH) , 6.83 (t, J=8.9Hz, IH) 3.08 (s, 3H) ; "F NMR (CDCI 3 ) -108.40 (m) , -108.69 (m) . Mass spectrum: M+H=462. Example 5 2- (2-Chlorophenyl) -4- (2-methylphenyl ) -5- (4- methylsulfonylphenyl ) thiazole Step 1; Preparation of 2- (2-methylphenyl) -3- (4- methvlthiophenvDpropenoic acid: A mixture of acetic anhydride (160 mL) , 4- (methylthio)benzaldehyde (25.32 g, 166 mmol), 2- methylphenylacetic acid (24.95 g, 166 mmol), and triethylamine (17.89 g, 176 mmol) was heated to reflux for 2.67 hours. The reaction was cooled to 100°C, and water (200 mL) was added. A clear oil formed that solidified upon chilling with an ice bath. The solid was collected by filtration, and recrystallized from a mixture of ethyl acetate and isooctane to give the desired acid in two crops (18.6 g, 39%): mp 134-137°C. i H NMR (CDCI3) 300 MHz 9.80 (br s, IH) , 7.91 (s, IH) , 7.28 (m, 3H) , 7.12 (d, J=7.5Hz, IH) , 7.00 (d, J=8.5Hz, 2H) , 6.93 (d, J=8.5Hz, 2H) , 2.42 (s, 3H) , 2.16 (s, 3H) . High resolution mass spectrum Calc'd. for C 17 H 16 O 2 S: 284.0871. Found: 284.0863. Step 2: Preparation of 1- <2-methvlnhenyl)2- (4- methvlthiophenvl) thanone: A solution of the acid from Step 1 (8.29 g, 29.2 mmol) and triethylamine (3.46 g, 34.2 mmol) dissolved in 30 mL of anhydrous toluene, was cooled to 0°C and treated with diphenylphosphoryl azide (8.23 g, 29.9 mmol) . The solution was maintained at 0°C for 45 minutes and warmed to room temperature for 3.75 hours. The reaction was poured into water, extracted with ether, dried over magnesium sulfate, and concentrated in vacuo to remove the ether. The remaining toluene solution was heated to 110°C for 1 hour. tert-Butyl alcohol (6 mL, 63 mmol) was added to the reaction mixture, after an additional twenty minutes, concentrated hydrochloric acid (2.6 mL) was cautiously added and the reaction maintained at 90°C overnight (16 hours) . After cooling the solution to room temperature, the mixture was concentrated in vacuo and the residue was taken up in ethyl acetate, washed successively with water, sat. aq. NaHC0 3 and brine, dried over anhydrous MgS0 4 , filtered and concentrated in vacuo to give a yellow solid (6.44 g, 86%): mp 54- 61°C. iH NMR (CDCI3) 300 MHz 7.69 (d, J=7.7Hz, IH) , 7.36 (m, IH) , 7.20-7.26 (m, 4H) , 7.16 (d, J=8.5Hz, 2H) , 4.17 (s, 2H), 2.46 (s, 3H) , 2.44 (s, 3H) . Mass spectrum M+H=257. Step 3: Preparation of 2-bromo-l- (2-methvlphenvl) -2- (4-methvlthiophenvl) thanone: A solution of the ketone from Step 2 (5.92 g, 23.1 mmol) in acetic acid (50 mL) and 33% HBr in acetic acid (2 mL) was treated with a 1.1 M solution of bromine in acetic acid (21.7 mL, 23.8 mmol) and stirred at room temperature for 2 hours. The solution was concentrated in vacuo and the residue taken up in dichloromethane, washed with IN NaHS0 3 and sat. aq. NaHC0 3 , dried over anhydrous MgS0 4 , filtered and concentrated in vacuo to give a yellow solid which was used directly in the next step without further purification (5.97 g, 77%): mp 85-89°C . iH NMR (CDCI 3 ) 300 MHz 7.56 (d, J=7.9Hz, IH) , 7.41 (d, J=8.5Hz, 2H) , 7.37 (d, J=7.7Hz, IH) , 7.22 (m, 4H) , 6.18 (s, IH) , 2.47 (s, 3H) , 2.44 (s, 3H) . Mass spectrum M+H=341. Step 4: Preparation of 2- (2-ohlorophenvl) -4- (2- me hvlphenvl)-5- (4-methvlthiophenvl ) thiazole: A solution of the bromoketone intermediate from Step 3 (0.68 g, 2.03 mmol) and 4-chlorothiobenzamide (0.34 g, 1.98 mmol) in 10 mL of acetonitrile was heated to reflux for 16 hours. The solution was cooled to room temperature and poured into 30 mL of methanol, chilled with an ice bath whereupon crystals of pure thiazole formed which were isolated by filtration and air dried to afford the desired thiazole (220 mg, 27%): mp 116-119°C. iH NMR (CDCI 3 ) 300 MHz 8.33 (m, IH) , 7.50 (m, IH) , 7.16-7.36 (m, 8H) , 7.12 (d, J=8.7Hz, 2H) , 2.46 (s, 3H) , 2.18 (s, 3H) . Mass spectrum: M+=407. Step 5: Preparation of 2- (2-chlorophenyl) -4- (2- methvlphenvl)-5- (4-methvlsulfonvlphenvl) thiazole: A solution of the thiazole from Step 4 (220 mg, 0.54 mmol) in 5 mL of dichloromethane was treated with MCPBA (390 mg, 1.13 mmol) at room temperature for 55 minutes. The solution was diluted with additional dichloromethane, washed with 10% aq. NaHS0 3 , and 10% a2C0 3 , dried over anhydrous MgSθ 4 , filtered and concentrated in vacuo to give a yellow powder that was recrystallized from a mixture of dichloromethane and isooctane to give a yellow solid (44 mg, 18%) : mp 156.5-157°C. lH NMR (CDCl 3 ) 300 MHz 8.38 (m, IH) , 7.79 (d, J=8.6Hz, 2H) , 7.52 (m, IH) , 7.46 (d, J=8.3Hz, 2H) , 7.39 (m, 2H) , 7.21-7.34 (m, 4H) , 3.05 (s, 3H) , 2.19 (s, 3H) . High resolution mass spectrum Calc'd. for C 2 3H 1 8CINO 2 S 2 : 439.0468. Found: 439.0476. Example 6 2- (2-Chlorophenyl) -5- (4-methylsulfonylphenyl ) 4- (2-thienyl)thiazole Step 1: Preparation of 3- (4-methvlthiophenvl) -2- (2- thienvDpropenoic acid: A mixture of acetic anhydride (90 mL) , 4- (methylthio)benzaldehyde (13.17 g, 82.2 mmol), 2- (2- thienyl)acetic acid (12.09 g, 83.3 mmol), and triethylamine (8.60 g, 85 mmol) was heated to reflux for 4 hours. The reaction was cooled to 85°C, and water (80 mL) was added. A brown solid was isolated by filtration and air dried to afford the propenoic acid (8.48 g, 37%): mp 201-206°C. lH NMR (DMSO-d 6 ) 300 MHz 12.80 (br s, lH) , 7.77 (s, IH) , 7.60 (d, J=5.2Hz, IH) , 7.09 (m, 5H) , 6.92 (d, J=3.3Hz, IH) , 2.42 (s, 3H) . 3c NMR (DMSO-d 6 ) 168.24,141.60, 141.30, 136.84, 131.08, 130.86, 128.46, 127.86, 125.51, 125.28, 14.52. Mass spectrum: M+H=277. Step 2: Preparation of 2- (4-methvlthiophenyl) -1- (2- thi nv )ethanone: A solution of the propenoic acid intermediate from Step 1 (8.13 g, 29.4 mmol) and triethylamine (3.33 g, 32.9 mmol) dissolved in 40 mL of anhydrous toluene, was cooled to 0°C and treated with diphenylphosphoryl azide (8.15 g, 29.6 mmol) . The solution was maintained at 0°C for twenty minutes and warmed to room temperature for 4 hours. The reaction was poured into water, extracted with ether, dried over magnesium sulfate, and concentrated in vacuo to remove the ether. The remaining toluene solution was heated to 110°C for 1.5 hours. tert-Butyl alcohol (8.5 mL, 85.6 mmol) was added to the reaction mixture. After an additional twenty minutes, concentrated hydrochloric acid (5 mL) was cautiously added and the reaction maintained at 90°C overnight (16 hours) . After cooling with an ice bath, a solid separated and was isolated by filtration. The filtrate was concentrated in vacuo and the residue taken up in dichloromethane washed with water, sat. aq. NaHCθ 3 and brine, dried over anhydrous MgS0 4 , filtered and concentrated in vacuo to give a brown solid. The two batches of solid were combined and recrystallized from a mixture of dichloromethane and isooctane to give the ketone as a light brown solid (3.02 g, 41 %): mp 100- 101°C. IH NMR (CDCI 3 ) 300 MHz 7.76 (dd, J= 3.8Hz, 1.1Hz, IH) , 7.63 (dd, J=4.9Hz, 1.1Hz, IH) , 7.22 (s, 4H) , 7.12 (dd, J=4.9Hz, 3.8Hz, lH) , 4.15 (s, 2H) , 2.46 (s, 3H) . 13c NMR (CDCI 3 ) 300 MHz 190.28, 143.80, 137.22, 134.05, 132.61, 131.18, 129.89, 128.19, 127.08, 45.85, 15.99. Mass spectrum: M'+H=249. Step 3: Preparation of 2-bromo-2- (4-methvlthiophenv] ) - 1- (2- hienvl)ethanone: A solution of the ketone from Step 2 (3.02 g, 12 mmol) in acetic acid (70 mL) and 33% HBr in acetic acid (4 mL) was treated with a 0.99 M solution of bromine in acetic acid (13 mL, 12.8 mmol) and stirred at room temperature for 2 hours. The solution was concentrated in vacuo and the residue taken up in dichloromethane, washed with IN NaHSθ 3 , and 10% Na2C0 3 , dried over anhydrous MgSθ 4 , filtered and concentrated in vacuo to give the bromoketone as a brown solid (2.95 g, 74%): mp 60-64.5°C. H NMR (CDCI3) 300 MHz 7.75 (d, J= 4.0Hz, IH) , 7.66 (d, J=4.8Hz, IH) , 7.45 (d, J=8.3Hz, 2H) , 7.22 (d, J=8.3Hz, 2H) , 7.10 (m, IH), 6.19 (s, IH) , 2.46 (s, 3H) ; 13c NMR (CDCI3) 300 MHz 184.08, 140.67, 140.62, 135.39, 133.53, 132.26, 129.52, 128.53, 126.50, 51.30, 15.42. Mass spectrum: M+H=328. Step 4: Preparation of 2- (2-chlorophenyl) -5- (4- methvlthiophenvl) -4- (2-thienvl) hiazole: A solution of the bromoketone from Step 3 (340 mg, 1.0 mmol) and 4-chlorothiobenzamide (180 mg, 1.0 mmol) in 3 mL of acetonitrile was heated to reflux for 5 hours. The solution was cooled to room temperature, poured into 30 mL of methanol and chilled with an ice bath whereupon crystals of pure thiazole formed which were isolated by filtration and air dried to afford the desired thiazole (180 mg, 42%) which was used directly in the next step. lH NMR (CDCI 3 ) 300 MHz 8.39 (d, J=6.2Hz, IH) , 7.22-7.51 (m, 8H) , 7.14 (d, J=3.4Hz, IH) , 6.94 (m, IH) , 2.54 (s, 3H) . Step 5: Preparation of 2- (2-chlorophenyl) -5- (4- methvlsulfonvlphenvl) -4- (2-thienvl) thiazole: A solution of the thiazole from Step 4 (140 mg, 0.35 mmol) in 3 mL of dichloromethane was treated with MCPBA (250 mg, 0.72 mmol) at room temperature for 2 hours. The solution was diluted with additional dichloromethane, washed with 10% aq. NaHSθ 3 , and 10% a 2 C0 3 , dried over anhydrous MgS0 4 , filtered and concentrated in vacuo to give a green solid that was purified by flash chromatography on silica gel eluting with hexane ethyl acetate to give white solid (100 mg, 67%) : mp 171-174°C. lH NMR (CDCl 3 ) 300 MHz 8.41 (dd, J=7.3Hz 1.8Hz, IH) , 7.99 (d, J=8.3Hz, 2H) , 7.77(d, J=8.5Hz, 2H) , 7.50 (d, J=7.7Hz, lH) , 7.40 (m, 2H) , 7.30 (d, J=4.0Hz, IH) , 7.09 (d, J=3.6Hz, IH) , 6.95 (m, IH) , 3.12 (s, 3H) . High resolution mass spectrum Calc'd. for C 20 H 15 CINO 2 S 3 (M+H) : 431.9953. Found: 431.9954. Example 7 2- (2 -Chlorophenyl) -5- ( 4 -methylsulf onylphenyl ) - 4 - ( 3 -thienyl ) thiazole St P JL: Preparation of 3- (4-methvlthiophenvl) -2- (3- thienvDpropenoic acid: A mixture of acetic anhydride (100 mL) , 4- (methylthio)benzaldehyde (11.06 g, 72.7 mmol), 3- thiopheneacetic acid (10.33 g, 72.7 mmol), and triethylamine (7.68 g, 75.9 mmol) was heated to reflux for 3 hours. The reaction was cooled to 90°C, and water (100 mL) was added. A white solid separated from the solution was isolated by filtration and air dried to afford the acid (11.0 g, 55%): mp 184-189°C. lH NMR (DMSO-d 6 ) δ 300 MHz 12.61 (br s, lH) , 7.69 (s, IH) , 7.54 (d, J=4.7Hz, IH) , 7.31 (s, IH) , 7.08 (d, J=8.7Hz, 2H) , 7.02 (d, J=8.7Hz, 2H) , 6.89 (d, J=5.lHz, IH) , 2.41 (s, 3H) ; 1 3 C NMR (DMSO-d 6 ) 168.63,140.70, 139.70, 136.22, 131.29, 130.89, 129.35, 127.74, 126.57, 125.53, 125.06, 14.57. Mass spectrum: M+H = 277. Step 2: Preparation of 2- (4-methvlthiophenyl) -1- (3- thienvl) thanone: A solution of the acid from Step 1 (7.20 g, 26.1 mmol) and triethylamine (2.83 g, 28 mmol) dissolved in 30 mL of anhydrous toluene, was cooled to 0°C and treated with diphenylphosphoryl azide (7.72 g, 28.1 mmol) . The solution was maintained at 0°C for thirty minutes and warmed to room temperature for 3 hours. The reaction was poured into water, extracted with ether, dried over magnesium sulfate, and concentrated in vacuo to remove the ether. The remaining toluene solution was heated to 100°C for 1.5 hours. tert- Butyl alcohol (3 mL, 31.8 mmol) was added to the reaction mixture. After an additional fifteen minutes, concentrated hydrochloric acid (2 mL) was cautiously added and the reaction maintained at 80°C for 72 hours. After cooling with an ice bath, a solid separated and was isolated by filtration. The filtrate was concentrated in vacuo and the residue taken up in dichloromethane, washed with water, sat. aq. NaHC0 3 , and brine, dried over anhydrous MgS0 4 , filtered and concentrated in vacuo to give a brown solid. The two batches of solid were combined and recrystallized from a mixture of ethyl acetate and hexane to give a light brown solid. Washing the solid with ether afforded pure white ketone (5.0 g, 77%): mp 119-122°C. lH NMR (CDC1 3 ) 300 MHz 8.08 (m, IH) , 7.55 (d, J=5.2Hz, IH) , 7.30 (m, IH) , 7.21 (m, 4H) , 4.13 (s, 2H) , 2.46 (s, 3H) . Mass spectrum: M+H = 249. Step 3: Preparation of 2-bromo-2- (4-methvlthiophenvl) - l-(3-thienvl 1ethanone: A solution of the ketone from Step 2 (4.0 g, 16.1 mmol) in acetic acid (100 mL) and 33% HBr in acetic acid (5 mL) was treated with a 0.99 M solution of bromine in acetic acid (16.5 mL, 16.3 mmol) and stirred at room temperature for 1 hour. The solution was concentrated in vacuo and the residue taken up in dichloromethane, washed with IN NaHSθ 3 , and 10% Na 2 Cθ 3 , dried over anhydrous MgS0 4 , filtered and concentrated in vacuo to give a gray solid which was recrystallized from a mixture of ethyl acetate and isooctane to provide the bromoketone intermediate (4.22 g, 80%): mp 74-76.5°C. Mass spectrum: M+H = 328. Step 4: Preparation of 2- (2-chlorophenyl) -5- (4- methvlthiophenvl) -4- (3-thienvl)thiazole: A solution of the bromoketone from Step 3 (330 mg, 1.0 mmol) and 4-chlorothiobenzamide (180 mg, 1.0 mmol) in 10 mL of acetonitrile was heated to reflux for 15 hours. The solution was cooled to room temperature and poured into 30 mL of methanol, chilled with an ice bath, whereupon crystals of pure thiazole formed which were isolated by filtration and air dried to afford the thiazole which was used directly in the next step (230 mg, 58%): mp 102-103.5°C. lH NMR (CDC1 3 ) 300 MHz 8.39 (d, IH) , 7.57 (m, lH) , 7.49 (d, IH) , 7.39 (m, 4H), 7.26 (m, 4H) , 2.53 (s, 3H) . Mass spectrum: M+H=401. Step 5: Preparation of 2- (2-chlorophenyl) -5- (4- methvlsulfonvlphenvl) -4- (3-thienvl) thiazole: A solution of the thiazole from Step 4 (180 mg, 0.45 mmol) in 2 mL of dichloromethane was treated with MCPBA (330 mg, 0.95 mmol) at room temperature for 4 hours. The solution was diluted with additional dichloromethane, washed with 10% aq. NaHS0 3 , and 10% Na 2 Cθ 3 , dried over anhydrous MgS0 4 , filtered and concentrated in vacuo to give a yellow solid that was purified by flash chromatography on silica gel, eluting with hexane and ethyl acetate to give a white solid (60 mg, 32%) l H NMR (CDCI 3 ) 300 MHz 8.39 (m, IH) , 7.94 (d, J=8.5Hz, 2H) , 7 ' .70 (d, J=8.5Hz, 2H) , 7.56 (m, 2H) , 7.39 (m, 2H) , 7.28 (m, lH) , 7.17 (d, J=5.0Hz, IH) , 3.11 (s, 3H) . Mass spectrum: M+H = 432. Example 8 4 - ( 4 -Fluorophenyl ) - 5 - ( 4 -me hyl sul f onylphenyl ) - 2 - ( 4 -pyridyl ) thia zole Step 1 : Preparation of 4- ( 4-f luorophenyl ) -5- ( 4- methyl hiophenvl)-2-( -pyridyl)thiazole; A solution of the intermediate from Example 1, Step 3, 1- (4-fluorophenyl) -2- (4-methylthiophenyl) -2- bromoethanone, (1.58 g, 4.66 mmol) and thioisonicotinamide (670 mg, 4.84 mmol) in 25 mL of acetonitrile was heated to reflux for 23 hours. The solution was filtered, concentrated in vacuo and the residue taken up in dichloromethane. The dichloromethane solution was washed with sat. aq. NaHCθ 3 , and brine, dried over anhydrous MgS0 4 , filtered and concentrated in vacuo to give a brown oil that was purified by flash chromatography on silica gel eluting with 20% ethyl acetate in hexane to provide the desired thiazole as an oil that solidified upon standing (640 mg, 36%): mp 107-109°C. lH NMR (CDC1 3 ) 300 MHz 8.75 (br s, 2H) , 7.85 ( " d, J=5.9 Hz, 2H) , 7.56 (m, 2H) , 7.26 (d, J=8.5 Hz, 2H) , 7.22 (d, J=8.5 Hz, 2H) , 7.01 (t, J=8.5 Hz, 2H) , 2.50 (s, 3H) ; 1 9 F NMR (CDCI 3 ) -113.23 (m) . High resolution mass spectrum Calc'd. for C2 1 H 1 5FN 2 S 2 : 379.0661. Found: 379.0691. Step 2: Preparation of 4- (4-fluorophenyl) -5- (4- methvlsulfonvlphenvl) -2- (4-Pvridvl) hiazole: A solution of the thiazole from Step 1 (450 mg, 1.19 mmol) in 10 mL of dichloromethane was treated with MCPBA (850 mg, 2.46 mmol) at room temperature for 2.5 hours. The solution was diluted with additional dichloromethane, washed with 10% aq. NaHS0 3 , and 10% Na 2 Cθ 3 , dried over anhydrous MgS0 4 , filtered and concentrated in vacuo to give a yellow solid that was purified by recrystallization from a mixture of dichloromethane, ethanol and isooctane to provide the pure product (310 mg, 63%) : mp 171-176°C. lH NMR (CDC1 3 ) 300 MHz 8.25 (d, J=7.2Hz, 2H) , 7.90 (m, 4H) , 7.56 (d, J=8.7 Hz, 2H) , 7.50 (m, 2H) , 7.04 (t, J=8.7 Hz, 2H) , 3.09 (s, 3H) . "F NMR (CDCI 3 ) -111.83 (m) . High resolution mass spectrum Calc'd. for C 2 1H15FN 2 O2S 2 : 410.0559. Found: 410.0576. Example 9 2- (2 -Chlorophenyl) -4- ( 2 -chlorophenyl ) -5- (4- methylsulf onylphenyl ) thiazole Step 1: Preparation of 2- (2 -chlorophenyl) -3- ( - methvlthiophenvDpropenoic acid: A mixture of acetic anhydride (170 mL) , 4- (methylthio )benzaldehyde (20.93 g, 137 mmol), 2- chlorophenylacetic acid (23.43 g, 137 mmol), and triethylamine (14.97 g, 147 mmol) was heated to reflux for 2 hours. The reaction was cooled to 90°C, and water (180 mL) was added. A yellow solid that separated from the solution was isolated by filtration and air dried to afford the desired acid. The acid was recrystallized from a mixture of ethyl acetate and isooctane to afford 24.62 g (59%): mp 159-164°C. lH NMR (CDC1 3 ) 300 MHz 7.97 (s, IH) , 7.48 (d, J=7.9Hz, IH) , 7.17-7.35 (m, 3H) , 7.02 (d, J=8.7Hz 2H) , 6.97 (d, J=8.7Hz, 2H) , 2.43 (s, 3H) . High resolution mass spectrum Calc'd. for C 16 H 13 CIO 2 S: 304.0325. Found: 304.0334. Step 2: Preparation of 1- (2-chlorophenyl)2- (4- methvlthiophenvl)ethanone: A solution of the acid from Step 1 (17.88 g, 58.7 mmol) and triethylamine (9.53 g, 94.2 mmol) was dissolved in 50 mL of anhydrous toluene, cooled to 0°C and treated with diphenylphosphoryl azide (16.46 g, 59.8 mmol) . The solution was maintained at 0°C for 36 minutes and warmed to room temperature for 4 hours. The reaction was poured into water, extracted with ether, dried over, magnesium sulfate, and concentrated in vacuo. The remaining toluene solution was heated to 110°C for 1 hour. tert-Butyl alcohol (7 mL, 74 mmol) was added to the reaction mixture. After an additional twenty minutes, concentrated hydrochloric acid (5 mL) was cautiously added and the reaction maintained at 90°C for 16 hours. The solution was concentrated in vacuo and the residue taken up in ethyl acetate, washed with water, sat. aq. NaHCθ 3 , and brine, dried over anhydrous MgSθ 4 , filtered and concentrated in vacuo to provide the ketone as an orange oil (14.62 g, 90%) that was used in the next step without further purification: ^-H NMR (CDCI 3 ) 300 MHz 7.40-7.10 (m, 8H) , 4.20 (s, 2H) , 2.46 (s, 3H) . Step : Preparation of 2-bromo-l- (2-chlorophenyl) -2- ( -methylthiophenyl) thanon ; A solution of the ketone from Step 2 (13.82 g, 49.9 mmol) in acetic acid (80 mL) and 33% HBr in acetic acid (4 mL) was treated with a 1.1 M solution of bromine in acetic acid (46.8 mL, 51.3 mmol) and stirred at room temperature for 1.5 hours. The solution was concentrated in vacuo and the residue taken up in dichloromethane, washed with IN NaHS0 3 , and 10% Na 2 Cθ 3 , dried over anhydrous MgS0 4 , filtered and concentrated in vacuo to give the bromoketone as an orange solid (6.07 g, 34%) of sufficient purity to be used directly in the next step without further purification: mp 93-99°C. lH NMR (CDC1 3 ) 300 MHz 7.37-7.43 (m, 5H) , 7.41 (m, lH) , 7.22 (d, J=8.5Hz, 2H) , 6.21 (s, IH) , 2.47 (s, 3H) . Mass spectrum: M+H = 357. Step 4: Preparation of 2- (2-chlorophenyl) -4- (2- rh1orophenvl)-5- (4-methvlthiophenvl)thiazole: A solution of the bromoketone from Step 3, (1.14 g, 3.2 mmol) and 2-chlorothiobenzamide (550 mg, 3.2 mmol) in 10 mL of acetonitrile was heated to reflux for 16 hours. The solution was cooled to room temperature and poured into methanol. This solution was chilled whereupon a yellow solid separated that was isolated by filtration. The solid was air dried to provide pure thiazole (440 mg, 32%) : mp 116-120°C. lH NMR (CDCI 3 ) 300 MHz 8.33 (m, IH) , 7.29-7.52 (m, 7H) , 7.19(d, J=8.3Hz, 2H) , 7.14 (d, J=8.5Hz, 2H) , 2.46 (s, 3H) . Mass spectrum: M+=427. Step 5: Preparation of 2- (2-chlorophenyl) -4- (2- chlorophenyl)-5- (4-methvlsulfonvlphenvl) hiazole: A solution of the thiazole from Step 4 (440 mg, 1.02 mmol) in 5 mL of dichloromethane was treated with MCPBA (720 mg, 2.08 mmol) at room temperature for 0.9 hour. The solution was diluted with additional dichloromethane, washed with 10% aq. NaHS0 3 , and 10% Na 2 Cθ 3 , dried over anhydrous MgS0 4 , filtered and concentrated in vacuo to give a yellow solid. The solid was recrystallized from a mixture of dichloromethane and isooctane to provide pure product (270 mg, 57%) : mp 143-147°C. lH NMR (CDCI 3 ) 300 MHz 8.36 (m, IH) , 7.82 (d, J=8.3Hz, 2H) , 7.52 (m, IH) , 7.45 (m, 4H) , 7.38 (m, 4H) , 3.05 (s, 3H) . High resolution mass spectrum Calc'd. for C 22 H 15 CI 2 NO 2 S 2 : 458.9921. Found: 458.9903. Example 10 2- (2-Chlorophenyl) -4- (4-chlorophenyl) -5- (4- methylsulfonylphenyl ) thiazole Step 1: Preparation of 2- ( -chlorophenyl) -3- (4- methvlthiophenvDpropenoic acid: A mixture of acetic anhydride (80 mL) , 4- (methylthio)benzaldehyde (9.81 g, 61.2 mmol), 4- chlorophenylacetic acid (12.03 g, 70.5 mmol), and triethylamine (7.49 g, 7.42 mmol) was heated to reflux for 7 hours. The reaction was cooled to 90°C, and water (100 mL) was added. A yellow solid separated from the solution which was isolated by filtration and air dried to afford the desired acid. The acid was recrystallized from toluene (9.59 g, 51%) : mp 185- 187°C. lH NMR (CDCI 3 ) 300 MHz 7.91 (s, lH) , 7.35 (d, J=8.3Hz, IH) , 7.17-7.35 (m, 3H) , 7.03 (d, 2H) , 7.00 (d, J=8.7Hz, 2H) , 2.44 and 2.36 (ε, 3H) . Mass spectrum: M+H=305. Step 2: Preparation of 1- (4-chlorophenyl) -2- (4- mPthvl hiophenvl)ethanone: The acid from Step 1 (9.01 g, 29.6 mmol) and triethylamine (3.03 g, 29.9 mmol) were dissolved in 45 mL of anhydrous toluene, cooled to 0°C and treated with diphenylphosphoryl azide (8.22 g, 29.9 mmol) . The solution was maintained at 0°C for 10 minutes and warmed to room temperature for 2 hours. The reaction was poured into water, extracted with ether, dried over anhydrous MgSθ 4 , and concentrated in vacuo to remove the ether. The remaining toluene solution was heated to 90°C for 15 minutes. tert-Butyl alcohol (10 mL) was added to the reaction mixture. After an additional twenty minutes, concentrated hydrochloric acid (8 mL) was cautiously added and the reaction maintained at 90°C for 15 minutes. The solution was cooled to room temperature and a precipitate formed that was isolated by filtration, washed with ether and air dried to provide the desired ketone as a white solid (2.43 g, 30%) : mp 143-147.5°C. lH NMR (CDC1 3 ) 300 MHz 8.08 (d, J=8.8Hz, 2H) , 7.55 (d, J=8.5Hz, 2H) , 7.24 (m, 4H) , 4.35 (s, 2H) , 2.05 (s, 3H) . Mass spectrum: M+H=277. Ste 3 : Preparation of 2-bromo-l- (4-chlorophenyl) -2- (4-methvlthiophenvl)ethanone: A solution of the ketone from Step 2 (2.04 g, 7.37 mmol) in acetic acid (15 mL) and 48% HBr in acetic acid (2 mL) was treated with a 0.99 M solution of bromine in acetic acid (7.6 mL, 7.5 mmol) and stirred at room temperature for 2.25 hours. The desired product precipitated from the solution, was isolated by filtration and air dried to provide the bromoketone intermediate for use in the next step (0.91 g, 35%) : mp 114-115°C. lH NMR (CDCI 3 ) 300 MHz 7.90 (d, J=8.8Hz, 2H) , 7.40 (d, J=8.5Hz, 4H) , 7.23 (d, J=8.5Hz, 2H) , 6.28 (s, IH) , 2.47 (s, 3H) ; 1 c NMR (CDCI 3 ) 400 MHz 189.76, 140.68, 140.30, 132.44, 131.88, 130.54, 129.51, 129.19, 126.51, 50.57, 15.33. High resolution mass spectrum Calc'd. for Ci 5 Hι 2 BrClOS: 353.9481. Found: 353.9516. Step 4: Preparation of 2- (2-chlorophenyl) -4- (4- chlorophenvl)-5- (4-methvlthiophenvl) thiazole: A solution of the bromoketone intermediate from Step 3, (890 mg, 2.5 mmol) and 2-chlorothiobenzamide (430 mg, 2.5 mmol) in 15 mL of acetonitrile was heated to reflux for 16 hours. The solution was diluted with ethyl acetate washed with sat. aq. NaHC0 3 , dried over anhydrous MgSθ , filtered and concentrated in vacuo to afford a white solid. The crude material was purified by flash chromatography on silica gel eluting with 8% ethyl acetate in hexane to give the desired thiazole as a white solid (370 mg, 34%): mp 122-124°C. lH NMR (CDCI 3 ) 300 MHz 8.37 (m, IH) , 7.56 (d, J=8.5Hz, 2H) , 7.50 (m, IH) , 7.20-7.39 (m, 8H) , 2.51 (s, 3H) . Mass spectrum: M+H = 429. Step 5: Preparation of 2- (2-chlorophenyl) -4- (4- chlorophenvl) -5- (4-methylsulfonvlphenvl) thiazole: A solution of the thiazole from Step 4 (300 mg, 0.7 mmol) in 10 mL of dichloromethane was treated with MCPBA (530 mg, 1.5 mmol) at room temperature for 1 hour. The solution was diluted with additional dichloromethane, washed successively with 10% aq. NaHSθ 3 , and 10% Na 2 Cθ 3 , dried over anhydrous MgS0 , filtered and concentrated in vacuo to give a yellow solid. The solid was recrystallized from a mixture of dichloromethane and isooctane to provide pure product (180 mg, 56%) : mp 177-179°C. lH NMR (CDCI 3 ) 300 MHz 8.37 (m, IH) , 7.91 (d, J=8.7Hz, 2H) , 7.62 (d, J=8.5Hz, 2H) , 7.50 (d, 3H) , 7.40 ( , 2H) , 7.34 (d, J=8.7Hz, 2H) , 3.10 (s, 3H) . High resolution mass spectrum Calc'd. for C 22 H 15 CI 2 NO 2 S 2 : 458.9921. Found: 458.9922. Example 11 2- (2-Chlorophenyl) -4- (4-methoxyphenyl ) -5- ( 4- methylsulfonylphenyl ) thiazole Step 1: Preparation of 2- (4-methoxyphenyl) -3- (4- methvlthiophenvDpropenoic acid: Acetic anhydride (350 mL) , 4- (methylthio)benzaldehyde (61.6 g, 0.61 mol), 4- methoxyphenylacetic acid (100.0 g, 0.60 mol) and triethylamine (68.1 g, 0.67 mol) were heated to reflux for 4 hours. The reaction was cooled to 110°C, and water (350 mL) was added. This caused the solution to reflux vigorously and the temperature rose to 135°C. A yellow precipitate formed and, after cooling to room temperature, was collected by filtration, washed with water and air dried. The product was crystallized from ethyl acetate/ethanol to give the desired acid as bright yellow needles (127.6 g, 71%): mp 174-177°C. lH NMR (CDCI 3 ) 300 MHz 8.89 (s, IH) , 7.16 (d, J=8.6Hz, 2H) , 7.02 (s, 4H) , 6.92 (d, J=8.6Hz, 2H) , 3.84 (s, 3H) , 2.43 (s, 3H) . Mass spectrum: M+H = 300. Step 2: Preparation of 1- (4-methoxyphenyl) -2- (4- methvlthiophenvl) thanone: The acid from Step 1 (23.0 g, 76.6 mmol) was added to anhydrous toluene (100 mL) and triethylamine (7.98 g, 79 mmol) . After cooling to 0°C, diphenylphosphoryl azide (21.27 g, 79 mmol) was added, the solution was stirred at 0°C for twenty minutes at room temperature for 2.50 hours. The mixture was poured into water, extracted with ether, dried over magnesium sulfate, and concentrated in vacuo . The remaining toluene solution was heated to 100°C whereupon a vigorous evolution of gas occurred. After 1.25 hours, tert-butyl alcohol (8.2 mL) was added to the reaction, and after an additional twenty minutes, concentrated hydrochloric acid (7 mL) was added. The reaction was heated at 75°C overnight (14 hours) and after cooling a white precipitate formed. The precipitate was filtered, washed with cold ether, and air dried to yield the light yellow ketone (19.3 g, 93%) : mp 134.5-138°C. lH NMR (CDC1 3 ) 300 MHz 7.99 (d, J=8.9Hz, 2H) , 7.20 (m, 4H) , 6.93 (d, J=8.9Hz, 2H) , 4.18 (s, 2H) , 3.84 (s, 3H) , 2.44 (s, 3H) ; 1 3 C NMR (CDCI 3 ) 300 MHz 196.18, 163.65, 136.87, 131.92, 131.00, 129.97, 129.64, 127.15, 113.92, 55.58, 44.78, 16.11. Mass spectrum: M+H = 273. Step 3: Preparation of 2-bromo-l- (4-methoxyphenyl) -2- (4-methvlthiophenvl)ethanon : The ketone from Step 2 (19.3 g, 71 mmol) was dissolved in a mixture of glacial acetic acid (125 mL) and 33% HBr in acetic acid (3.4 mL) and treated with a 0.99 M solution of bromine in acetic acid (73 mL, 72 mmol) at room temperature for 3 hours. The solution was diluted with dichloromethane, washed successively with water, and 10% aq. NaHS0 3 , dried over anhydrous MgSθ 4 , filtered and concentrated in vacuo to give the desired bromoketone intermediate which was crystallized from a mixture of dichloromethane and isooctane (14.3 g, 57%): mp 90-93°C. *H NMR (CDCI 3 ) 300 MHz 7.95 (d, J=9.lHz, 2H) , 7.42 (d, J=8.5Hz, 2H) , 7.22 (d, J=8.5Hz, 2H) , 6.92 (d, J=9.lHz, 2H ), 6.33 (s, IH) , 3.85 (s, 3H) , 2.46 (s, 3H) . Mass spectrum: M+H = 352. Step 4: Preparation of 2- (2-chlorophenyl) -4- (4- methoxvphenvl) -5- (4-methvlthiophenvl)thiazole: A mixture of the bromoketone intermediate from Step 3 (3.22 g, 9.17 mmol) and 2-chlorothiobenzamide (1.65 g, 9.62 mmol) in acetonitrile (40 mL) was stirred at room temperature for 24 hours. During this time a solid precipitated from solution which was isolated by filtration and air dried to give the desired thiazole (3.26 g, 84%): mp 159-161°C . lH NMR (CDC1 3 ) 300 MHz 8.38 (m, IH) , 7.54 (d, J=8.9Hz, 2H) 7.48 (d, IH) , 7.33 (m, 4H) , 7.22 (d, J=8.5Hz, 2H) , 6.88 (d, J=8.9Hz, 2H) , 3.82 (s, 3H) , 2.51 (s, 3H) . Mass spectrum: M+H = 424. Step 5: Preparation of 2- (2-chlorophenyl) -4- (4- methoxvphenvl ) -5- (4-methvlsulfonvlphenvl) thiazole: A dichloromethane (5 mL) solution of the thiazole from Step 4 (0.30 g, 0.7 mmol) was treated with MCPBA (0.53 g, 1.5 mmol) and stirred at room temperature for 24 hours. The solution was successively washed with 10% aq. NaHSθ 3 , and 10% Na 2 C0 3 , dried over anhydrous MgS04, filtered and concentrated in vacuo to give a yellow solid that was crystallized from a mixture of dichloromethane and isooctane to afford pure product (190 mg, 59%): mp 171.5-173.5°C. H NMR (CDCI 3 ) 300 MHz 8.39 (m, IH) , 7.88 (d, J=8.5Hz, 2H) 7.63 (d, J=8.3Hz, 2H) , 7.49 (m, 3H) , 7.38 (m, 2H) , 6.90 (d, J=8.9Hz, 2H) , 3.83 (s, 3H) , 3.09 (s, 3H) . High resolution mass spectrum Calc'd for C 23 H lg ClN0 3 S 2 : 455.0417. Found: 455.0416. Mass spectrum: M+H = 455.0461. Example 12 2- ( 3-Chloro-4-fluorophenyl) -4- (4-fluorophenyl ) - 5- (4-methylsulfonylphenyl) thiazole Step 1: Preparation of 2- (3-chloro-4-fluorophenyl) -4- (4-fluorophenyl) -5- (4-methvlthiophenyl) thiazole: A solution of the intermediate from Example 1 Step 3, 1- (4-fluorophenyl) -2- (4-methylthiophenyl) -2- bromoethanone, (1.96 g, 5.78 mmol) and 3-fluoro-4- chlorothiobenzamide (1.14 g, 6.01 mmol) in 15 mL of acetonitrile was heated to reflux for 16 hours. The solution was cooled to room temperature, poured into 50 mL of methanol and chilled in an ice bath'«*hereupon the desired product precipitated. The crude thiazole was recrystallized from methanol to provide the desired thiazole (1.44 g, 58%): mp 113-118°C. X H NMR (CDCI 3 ) 300 MHz 8.10 (dd, J=7.0Hz, 2.2Hz, IH) , 7.85 (m, IH) , 7.57 (m, 2H) , 7.26 (m, 5H) , 7.02 (t, J=8.5 Hz, 2H) , 2.51 (s, 3H) . 19F NMR (CDCI 3 ) -112.92 (m) , -113.44 (m) . Mass spectrum M+H = 429. Step 2: Preparation of 2- (3-chloro-4-fluorophenyl) -4- (4- luorophenyl) -5- (4-methylsulfonvlphenvl) hiazol : A dichloromethane (20 mL) solution of the thiazole from Step 1 (910 mg, 2.12 mmol) was treated with MCPBA (1.48 g, 4.29 mmol) ' and stirred at room temperature for 30 minutes. The solution was successively washed with 10% aq. NaHS03 , and 10% Na2C03, dried over anhydrous MgS04, filtered and concentrated in vacuo to give a yellow solid that was crystallized from a mixture of dichloromethane and isooctane to afford pure product (770 mg, 79%) : mp 165-167°C. H NMR (CDCI3) 300 MHz 8.10 (d, lH) , 7.90 (d, J=8.lHz, 2H) , 7.85 (m, lH) , 7.54 (m, 4H) , 7.24 (t, IH) , 7.05 (t, J=8.5 Hz, 2H) , 3.10 (s, 3H) ; 1 9 F NMR (CDCI 3 ) -112.06 (m) , -112.29 (m) . High resolution mass spectrum Calc'd. for C 2 2H 14 CIF 2 NO 2 S 2 : 462.0201. Found: 462.0138. Example 13 4- (4-Fluorophenyl) -5- ( -methylsulfonylphenyl) - 2- (2-thienyl ) sulfonyImethyl ) thiazole tep 1: Preparation of 4- (4-fluoroohenvl) -5- (4- methvlthiophenvl) -2- (2- thienvl) sulfonv ethvl)thiazole: A solution of the intermediate from Example 1 Step 3, 1- (4-fluorophenyl) -2- (4-methylthiophenyl) -2- bromoethanone, (4.33 g, 12.76 mmol) and (2- thienyl) sulphonylthioacetamide (2.55 g, 11.5 mmol) in 25 mL of acetonitrile was heated to reflux for 16 hours. The solution was cooled in an ice bath and a precipitate formed that was removed by filtration. The filtrate was concentrated in vacuo and the residue was dissolved in ethyl acetate, washed successively with sat. aq. NaHC03 , and brine, dried over anhydrous MgS04, filtered and concentrated in vacuo to provide a brown oil that was purified by flash chromatography on silica gel, eluting with 30% ethyl acetate in hexane. The appropriate fractions were combined and /03392 PCMJS9 105 concentrated and finally recrystallized from a mixture of dichloromethane and isooctane to provide 2.16 g (41%) of pure thiazole: mp 120-121°C. H NMR (CDCI 3 ) 300 MHz 7.74 (d, J= 4.9Hz, IH) , 7.67 (m, IH) , 7.33 (m, 2H) , 7.21 (m, 5H) , 6.95 (t, J=8.7Hz, 2H) , 4.87 (s, 2H) , 2.49 (s, 3H); "F NMR (CDCI 3 ) -113.33 (m) . High resolution mass spectrum Calc'd. for C 21 H 16 FNO 2 S 4 : 461.0048. Found: 461.0090. Step 2: Preparation of 4- (4-fluorophenyl) -5- (4- methvlsulfonvlohenvl) -2- (2-thienvl) sulfonvlmethvl) - thiazole: A dichloromethane (15 mL) solution of the thiazole from Step 1 (1.74 g, 3.8 mmol) was treated with MCPBA (2.68 g, 7.8 mmol) and stirred at room temperature for 1 hour. The solution was successively washed with 10% aq. NaHSθ3 , and 10% Na2C03, dried over anhydrous MgS04, filtered and concentrated in vacuo to give a yellow foam. The foam was crystallized from a mixture of dichloromethane and isooctane to afford 1.55 g, (86%) of pure product as a white solid: mp 98- 105°C. lH NMR (CDCI3) 300 MHz 7.91 (d, J= 8.5Hz, 2H) , 7.77 (dd, J=4.8Hz 1.4Hz, IH) , 7.68 (dd, J=3.7Hz 1.1Hz, IH) , 7.51 (d, J=8.lHz, 2H) , 7.29 (m, 2H) , 7.17 (t, J=4.8Hz, IH) , 6.98 (t, J=8.8Hz, 2H) , 4.89 (ε, 2H) , 3.09 (s, 3H) ; ^F NMR (CDCI3) -112.13 (m) . High reεolution maεs spectrum Calc'd. for C 21 H 17 FNO4S4 (MH+) : 494.0025. Found: 494.0005. Example 14 4- (4-Fluorophenyl ) -5- (4-methylsulfonylphenyl) - 2- ( 2-thienyl ) sulfonylbromomethy1 ) -thiazole The product from Example 13 Step 2, [4- (4- fluorophenyl) -5- (4-methylsulfonylphenyl) -2- (2- thienyl) sulfonyImethyl) -thiazole] , (0.38 g, 0.76 mmol) was dissolved in chloroform (20 mL) . The solution was treated with 0.80 mL of a solution of bromine in acetic acid ( 0.99 M, 0.78 mmol) and stirred at room temperature for 0.58 hour and was treated with a 10% solution of NaHS03. The organic layer was collected, washed with saturated NaHC03 , dried over magnesium sulfate and concentrated in vacuo to give a white foam (0.46 g) which was a mixture of the brominated compound and starting material. This mixture was purified by flash chromatography on silica gel, eluting with 30% ethyl acetate in hexane to give the product as a white foam (0.20 g, 45%): lH NMR (CDCI 3 ) 300 MHz 7.90 (d, J= 8.5Hz, 2H) , 7.86 (dd, J=4.8Hz 1.1Hz, IH) , 7.79 (dd, J=3.7Hz 1.1Hz, IH) , 7.55 (d, J=8.5Hz, 2H) , 7.31 (m, 2H) , 7.21 (t, J=4.7Hz, IH) , 6.98 (t, J=8.8Hz, 2H) , 6.24 (ε, 2H) , 3.09 (s, 3H) ; i F NMR (CDCI 3 ) -111.85 (m) . Field desorption mass spectrum: M+Li = 579. Example 15 2- (2-Chlorophenyl) -5- (4-methylsulfonylphenyl ) - 4- ( -methylphenyl ) thiazole Step 1; Pr par tion Of 3- (4-methvlthiophenvl-2- (4- methvlphenvDpropenoic acid. 4-Methylthiobenzaldehyde (16.4 mL, 123.7 mmol) was added to 4-methylphenylacetic acid (26.0 g, 173.1 mmol), triethylamine (17.2 mL, 123.7 mmol) and 250 mL of acetic acid. The reaction was warmed to reflux and held at reflux for four hours. Upon cooling to approximately 110°C, water (250 mL) was added over ten minutes, such that foaming was controlled and the reaction temperature remained > . 90°C. This temperature was maintained for 16 hours, the thick suspenεion formed waε cooled to room temperature and filtered. The solid was washed with water and dried to yield the acid intermediate as orange crystalε (32.2 g; 91%) : mp 144-160°C. lH NMR (CDC1 3 ) 300MHz 7.87 (s, IH) , 7.41 - 7.02(m, 9H) , 2.43 (ε, 3H) , 2.40 (ε, 3H) . Step 2: Preparation of 2- (4-methvlthiophenvl) -1- (4- methvlphenvl) ethanone: 3- (4-Methylthiophenyl-2- (4-methylphenyl)propenoic acid from Step 1 (25 g, 87.91 mmol) was added to triethylamine (12.9 mL, 92.31 mmol) and toluene (200 mL) and cooled to 0°C. Diphenylphosphoryl azide (19 mL, 87.91 mmol) dissolved in toluene (100 mL) , was added to the reaction over approximately ten minutes, keeping the reaction temperature ≤. 10°C. After holding the reaction temperature at 0°C for 30 minutes, water (100 mL) was added, and the biphasic solution was extracted with toluene (2x200 mL) . The combined organic solution was dried over anhydrous MgS04 and filtered. Over approximately thirty minutes, the solution was carefully warmed to reflux and held for one hour. Upon removing the heat source, tert-butanol (9 mL, 96.7 mmol) was added, and reflux was continued for an additional thirty minutes. Concentrated HCI (8 mL, 96.8 mmol) was added with extreme caution, producing copious evolution of gas. After continuing reflux for a final twenty minutes, the reaction was cooled to room temperature, and held for 16 hours. The solvent volume was reduced in vacuo, until crystals appeared. Diethyl ether (300 mL) was added, and the suspension was cooled to 0°C, held for 30 minutes, filtered and washed with diethyl ether to provide, after air-drying, pure 2- (4-methylthiophenyl) -1- (4- methylphenyl)ethanone (11.3 g, 50%) : mp 120-121°C. lH NMR (CDCI 3 ) 300MHz 7.89(d, J=8.26 Hz, 2H) , 7.23 - 7.15(m, 6H) , 4.21(s, 2H) , 2.45(ε, 3H) , 2.40(ε, 3H) . Step 3: Preparation of 2-bromo-2- (4-methvlthiophenvl) - 1- (4-methvlphenvl) ethanone: 2- (4-Methylthiophenyl) -1- (4-methylphenyl) ethanone from Step 2 (10.0 g, 39.0 mmol) was added to 33% HBr in acetic acid (70 mL) and glacial acetic acid (100 mL) . Over approximately 20 minutes, a εolution of bromine in acetic acid (1 M, 39 mL) was added to the εuεpension, and the reaction was held at room temperature for one hour. Any undissolved solidε were removed by filtration, and the reaction waε concentrated in vacuo, to a residue. The residue was dissolved in methylene chloride (100 mL) , washed with 5% Na2S2θ5 (2x100 mL) , dried over MgS04, filtered, and concentrated in vacuo to a colorless oil. The oil was held under vacuum for 16 hours, yielding 2-bromo-2- (4- methylthiophenyl) -1- (4-methylpheny1) ethanone (8.38 g, 64%) as a dirty white solid: mp 97-98°C. H NMR (CDCI 3 ) 300MHz 7.86 (d, J = 8.46 Hz, 2H) , 7.80(d, J = 8.26 Hz, 2H) , 7.33 - 7.16(m, 4H) , 5.88(s, IH) , 2.43(s, 3H) , 2.36(s, 3H) . Step 4: Preparation of 2- (2-chlorophenyl) -4- (4- methvlphenvl) -5- ( -methvlthiophenvl ) thiazole: 2-Bromo-2- (4-methylthiophenyl) -1(4- methylphenyl)ethanone from Step 3 (0.300 g, 0.895 mmol) was added to acetonitrile (20 mL) . 2- Chlorothiobenzamide (0.154 g, 0.895 mmol) was added, and the suspenεion was heated and held at reflux for three hours. The reaction was cooled to room temperature, diluted with ethyl acetate (50 mL) and poured into water(50 mL) . The layers were separated, and the aqueous layer was extracted with ethyl acetate (2x30 mL) . The combined organic solution was dried over MgS04, filtered and evaporated in vacuo . The residue was purified via flash chromatography (silica gel; 5% ethyl acetate in hexane) to yield 2- (2- chlorophenyl) -4- (4-methylphenyl) -5- (4- methylthiophenyl) thiazole (0.284 g, 78%) as a white solid: mp 125-126°C. H NMR (CDCI 3 ) 300MHz 8.40 (m, IH) , 7.62 - 7.11(m, 11H) , 2.50 (s, 3H) , 3.36(s, 3H) . Mass spectrum: MH+ = 407. Step 5: Preparation of 2- (2-chlorophenyl) -5- (4- methvlsulfonvlphenvl)-4- (4-methvlphenvl)thiazole: 2- (2-Chlorophenyl) -4- (4-methylphenyl) -5- (4- methylthiophenyl)thiazole from Step 4 (0.243 g, 0.596 mmol) was added to aqueous ethanol (25 mL) . Oxone® (1.10 g, 1.787 mmol) was added, and the suspension was stirred at room temperature for 16 hours. Water (25 mL) was added, and the product precipitated. The suspension was cooled to 0°C and held for one hour. The product was filtered, washed with water (25 mL) , and dried to yield 2- (2-chlorophenyl) -5- (4- methylsulfonylphenyl) -4- (4-methylphenyl)thiazole (0.236 g, 90%) as a white solid: mp 185-187 °C. lH NMR (CDCI 3 ) 300MHz 8.40(m, IH) , 7.89(d, J = 8.26 Hz, 2H) , 7.61(d, J = 8.46 Hz, 2H) , 7.54 - 7.37(m, 5H) , 7.16(d, J = 7.85 Hz, 2H) , 3.09(s, 3H) , 2.38(s, 3H) . Mass spectrum: MH+ = 439. Example 16 2- (2-Chlorophenyl) -4- ( -fluorophenyl) -5- ( - methylsulfonylphenyl ) thiazole Step 1: Preparation of 2- (2-chlorophenyl) -4- (4- fluorophenvl)-5- (4-methvlthiophenvl) thiazole: To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylthiophenyl)ethanone (2.03 g, 5.98 mmol) (Example 1, Step 3) in acetonitrile (60 mL) in a 125 mL round bottom flask was added 2-chlorothiobenzamide (1.08 g, 6.28 mmol) and the suspension was heated to 80°C for 4 hours. The reaction was cooled to room temperature and the suspension was filtered. The solid was recrystallized from hot acetonitrile (50 mL) and methanol (150 mL) yielding 2- (2-chlorophenyl) -4- (4- fluorophenyl) -5- (4-methylthiophenyl) thiazole as a tan solid (1.23 g, 50 %) : mp 133-134°C. lH NMR (CDCl 3 ) 300 mHz δ 8.37 (d, J = 6.17 Hz, IH) , 7.60 (dd, J = 8.68, 5.28, 2H) 7.51 (d, J = 9.44 Hz, IH) , 7.32-7.42 (m, 2H) , 7.32 (d, J = 8.68 Hz, 2H) , 7.21 ( d, J = 8.68 Hz, 2H) , 7.02 (t, J = 8.68, 2H) , 2.51 (s, 3H) . MS (El) : m/z 412 (MH+) . Step 2: Preparation of 2- (2-chlorophenyl) -4- (4- fluorophenyl) -5- (4-methylsulfonvlphenvl)thiazole: To a solution of 2- (2-chlorophenyl) -4- (4- fluorophenyl) -5- (4-methylthiophenyl) thiazole from Step 1 (1.30 g, 3.16 mmol) in methylene chloride (30 mL) at room temperature was added MCPBA (2.03 g, 67% peroxide content, 7.89 mmol) in two portions (T = 0 hour and 1 hour) . After stirring for 6 hours, the hazy reaction mixture was diluted with methylene chloride (50 mL) and the resulting clear yellow solution was washed successively with NaHS03 solution (0.1 M, 3 X 20 mL) , NaHC03 saturated solution (3 X 50 mL) , and brine, dried over Na2S04, filtered and concentrated in vacuo yielding 2- (2-chlorophenyl) -4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl) thiazole (1.2 g, 86 %) as a yellow solid: mp 133-134°C. lH NMR (CDCI 3 ) 400 mHz δ 8.42-8.38 (m, IH) , 7.92 (d, J = 8.40 Hz, 2H) , 7.61 (d, J = 8.40 Hz, 2H) , 7.56-7.45 (m, 3H) , 7.38 (m, 2H) , 7.05 (t, J = 8.69 Hz, 2H) , 3.10 (s, 3H) . MS (EI- thermospray) : m/z 443 (M+H) . HRMS Δ = -2.5 mmu. Example 17 Ethyl [4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl) -2-thiazolyl] carboxylate Step 1: Synthesis of ethvl T4- (4-fluorophenyl) -5- (4- ethvlthiophenvl) -2-thiazolvl1 carboxylate: To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylthiophenyl) ethanone (1.014 g, 2.99 mmol) (Example 1, Step 3) in ethanol (30 mL) was added ethyl thiooxamate (0.428 g, 3.21 mmol) and the suspension was heated to reflux for 12 hours. The reaction was cooled to room temperature and let stand for 2 days. The crude reaction mixture was concentrated in vacuo, diluted with methylene chloride, washed with saturated NaHC03 solution, dried over Na2S04, filtered and concentrated in vacuo . The residue was purified by flash chromatography (9:1 hexane:ethyl acetate) and recrystallized from methylene chloride and isooctane yielding the ethyl [4- (4-fluorophenyl) -5- (4- methylthiophenyl) -2-thiazolyl]carboxylate as a pale yellow solid (0.352 g, 32 %) : mp 115-116°C. lH NMR (CDCI 3 ) 400 mHz δ 7.54-7.48 (m, 2H) , 7.25-7.20 (m, 4H) , 7.00 (t, J = 8.56 Hz, 2H) , 4.50 (q, J= 7.00 Hz, 2H) , 2.50 (s, 3H) . 1.46 (t, J = 7.09 Hz, 3H) . MS (El) : m/z 373 (M+) . HRMS Δ = 0.000 mmu. Step 2: Preparation of ethvl f4- (4-fluorophenvl) -5- (4- methvlsulfonvlphenvl)-2-thiazolvπcarboxylate: To a solution of ethyl [4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl) -2-thiazolyl] carboxylate from Step 1 (0.203 g, 0.544 mmol) in methylene chloride (10 mL) was added at 0°C MCPBA (0.294 g of 67 % peroxide content MCPBA, 1.14 mmol) . The reaction was warmed to room temperature and let stand for 3 days. The crude reaction mixture was diluted with methylene chloride (50 mL) and the resulting solution was washed successively with NaHS03 solution (0.1 M) , NaHC03 saturated solution and brine. The solution was dried over Na2S04, filtered and concentrated in vacuo yielding a white foam. This foam was crystallized from methylene chloride and isooctane to yield ethyl [4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2- thiazolyl] carboxylate as pale yellow small needles (0.150 g, 69 %) : mp 173-174°C. lH NMR (CDCI 3 ) 400 mHz δ 7.93 (d, J = 8.30 Hz, 2 H) , 7.55 (d, J = 8.30 Hz, 2H) , 7.48 (t, J = 8.79 Hz, • 2H) , 7.03 ( t, J = 8.79 Hz, 2H) , 4.52 (q, J = 7.32 Hz, 2H) , 3.09 ( s, 3H) , 1.46 (t, J = 7.33 Hz, 3H) . MS (El) : m/z 405 (M+) . HRMS Δ = -0.5 mmu. Example 18 2- ( ter -Butyl) -4- ( 4-fluorophenyl ) -5- (4- methylsulfonylphenyl ) thiazole Step 1 Preparation of 2.2- dimethvlthiopropionamide: To a solution of 2, 2-dimethylpropionamide (2.00 g, 19.77 mmol) in toluene (60 mL) was added Lawesson's reagent (4.00 g, 9.89 mmol) and the solution was heated to reflux for 12 hours. The crude reaction mixture was cooled to room temperature and was concentrated in vacuo . The crude product was purified by flash chromatography. The first column utilized 3:1 hexane:ethyl acetate yielding a white solid having a strong sulfurous aroma. This solid was further purified by flash chromatography (1:1 methylene chloride:hexane with 1 % acetic acid). The eluant, which contained the desired thioamide, was diluted with toluene and concentrated in vacuo yielding an oil. Treatment of this oil with isooctane yielded 2, 2-dimethylthiopropionamide (0.190 g, 8%) as a white powder which was used immediately: H NMR (CDCI 3 ) 300 mHz δ 9.40 (br s, IH) , 8.65 (br s, IH) , 1.19 (s, 9H) . Step 2: Preparation of 2- ( ert-butvl) -4- (4- fluorophenvl) - - ( -methvlthiophenvl)thiazole: To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylthiophenyl)ethanone (Example 1, Step 3) (0.196 g, 0.578 mmol) in ethanol (6 mL) was added 2,2- dimethylthiopropionamide from Step 1 (0.071 g, 0.606 mmol) and the mixture was heated to reflux overnight. The reaction was cooled to room temperature and diluted with ethyl acetate (50 mL) . This solution was washed successively with Na2C03 (10% solution) and brine, dried over Na2S04, filtered and concentrated in vacuo yielding 2- (tert-butyl) -4- (4-fluorophenyl) -5- (4- methylthiophenyl)thiazole as a pale yellow oil (0.162 g, 78%): lH NMR (CDCI3) 300 mHz δ 7.56-7.51 (m, 2H) , 7.24 (d, J = 8.48 Hz, 2H) , 7.20 (d, J = 8.48 Hz, 2H) , 6.98 (t, J = 8.85 Hz, 2H) , 2.49 (s, 3H) , 1.52 (s, 9H) . MS (El) : m/e 357 (M+) . HRMS Δ = 0.1 mmu. Step 3: Preparation of 2- (frerfr-hutvl ) -4- (4- fluorophenvl) -5- (4-methvlsulfonvlphenvl) thiazole: To a solution of 2- ( ert-butyl) -4- (4- fluorophenyl) -5- (4-methylthiophenyl)thiazole from Step 2 (0.110 g, 0.31 mmol) in methylene chloride (5 mL) at 0°C was added MCPBA (67 % peroxide content MCPBA) (0.080 g, 0.62 mmol initially) and the reaction was warmed to room temperature. Additional MCPBA was added (0.020 g, 0-15 mmol) later that day, more (0.040 g, 0.31 mmol) on day 4, and more (0.020 g, 0.15 mmol) later on day 4. The crude reaction mixture was diluted with methylene chloride (50 mL) and the resulting solution was washed successively with NaHS03 solution (0.1 M) , NaHC03 saturated solution and brine, dried over Na2S04, filtered and concentrated n vacuo. The crude product was recrystallized from methylene chloride and isooctane yielding 2- ( ert-butyl) -4- (4- fluorophenyl) -5- (4-methylsulfonylphenyl)thiazole as a white powder (0.059 g, 49 %) : mp 144-145°C. lH NMR (CDCI 3 ) 400mHz δ 7.87 (d, J = 8.30 Hz, 2H) , 7.51-7.45 (m, 4H) , 7.00 (t, J = 8.79, 2H) , 3.08 (s, 3H) , 1.50 (s, 9H) . MS (El) : m/z 390 (MH+) . HRMS Δ = 1.9 mmu. Example 19 2-Benzyl-4-(4-fluorophenyl ) -5- (4- methylsulfonylphenyl ) thiazole Step 1: Preparation of 2-benzvl-4- (4-fluorophenvl) -5- (4-methvlthiophenyl) thiazole: To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylthiophenyl) ethanone (Example 1, Step 3) (0.250 g, 0.737 mmol) in ethanol (9 mL) was added 2- phenylthioacetamide (0.111 g, 0.737 mmol) and the mixture was heated to reflux overnight. The reaction was cooled to room temperature, diluted with ethyl acetate (50 mL) , washed successively with Na2C03 (10 % solution) and brine, dried over Na2S04, filtered and concentrated in vacuo yielding an oil. This oil was dissolved in methylene chloride and isooctane yielding a suspension. The solid was removed by filtration and the filtrate reconcentrated in vacuo yielding 2- benzyl-4- (4-fluorophenyl) -5- (4- methylthiophenyl) thiazole as a yellow oil which was suitable based upon H NMR to be used without further purification. Step 2: Preparation of 2-benzvl-4- (4- luorophenvl) -5- (4-methylsulfonvlphenvl) hiazole: To a solution of 2- (benzyl) -4- (4-fluorophenyl) -5- (4-methylthiophenyl)thiazole from Step 1 (0.20 g, 0.50 mmol) in methylene chloride (10 mL) was added, at room temperature, MCPBA ( 0.29 g of 67% peroxide content MCPBA, 1.00 mmol) and the reaction was warmed to room temperature and let stand for 2 hours. The crude reaction mixture was diluted with methylene chloride (50 mL) and the resulting solution was washed successively with NaHS03 solution (0.1 M) , NaHC03 saturated solution, and brine, dried over a2S04, filtered and concentrated in vacuo yielding a solid. This solid was recrystallized from methylene chloride and isooctane yielding 2-benzyl-4- (4-fluorophenyl) -5- ( -methylsulfonylphenyl)thiazole as white needles (0.130 g, 56 %) : mp 117-118°C. 1H NMR (CDCI3) 400 mHz δ 7.83 (d, J = 8.56 Hz, 2H) , 7.5-7.3 (m, 9H) , 7.02 (t, 8.67 Hz, 2H) , 4.38 (s, 2H) , 3.06 (s, 3H) . MS (FAB) : m/z 424 (MH+) . Example 20 5- ( -Fluorophenyl) -4- ( -methylsulfonylphenyl) - 2-methylthiazole Step 1: Preparation of 1- (4-methvlthiophenvl)-2-(4- fluorophenvl) thanone: To a stirred solution of thioanisole (380 mL, 3.2 mol) and 4-fluorophenylacetyl chloride (300 g, 1.6 mol) in carbon disulfide (1.2 L) , cooled to 5°C, was added anhydrous aluminum chloride portionwise at such a rate that the internal temperature did not rise above 15°C. The reaction was stirred at room temperature for 16 hours. The solution was cautiously poured into 2 L of ice and water. The aqueous solution was extracted with methylene chloride (6x150 mL) , the combined extracts were dried over anhydrous MgS04, filtered and concentrated in vacuo . The residue was dissolved in 800 mL of ether and cooled to 0°C whereupon crystals of pure product formed which were isolated by filtration and air dried to provide the ketone (199.6 g, 48%) : mp 135-138°C. lH NMR (CDCI 3 /TMS) 300 MHz 8.00 (d, J=8.7 Hz, 2H) , 7.40-7.30 (m, 4H) , 7.13-7.03 (m, 2H) , 4.34 (s, 2H) , 2.56 (s, 3H) . Mass spectrum M+=260. Step 2: Preparation of 2-bromo-2- (4-fluorophenvl) -1- (4-methvlthiophenvl)ethanon : To a stirred slurry of 2- (4-fluorophenyl) -1- (4- methylthiophenyl)ethanone from Step 1 (5.04 g, 19.36 mmol) in acetic acid (100 mL) was added HBr in acetic acid (45 mL, 48 % by wt.) and bromine (1.0 mL, 3.09 g, 19.36 mmol) . The resulting green slurry became homogeneous within 30 minutes. After 4 hours, the reaction was concentrated in vacuo, the residue diluted with toluene, and reconcentrated in vacuo. The crude haloketone was purified by flash chromatography (2:1 hexane:methylene chloride) and recrystallized from ethyl acetate and isooctane yielding 2-bromo-2- (4-fluorophenyl) -1- (4- methylthiophenyl) ethanone as an off-white solid (4.51 g, 69 %) : mp 108-111 °C. lH NMR (CDCI 3 ) 300 mHz δ 7.94 (d, J = 8.79 Hz, 2H) , 7.60 - 7.50 (m, 2H) , 7.25 (d, J = 8.79 Hz, 2H) , 7.10 (t, J = 8.67 Hz, 2H) , 6.34 (s, IH) , 2.56 (s, 3 H) . Step 3: Preparation of 5- (4-fluorophenvl) -4- (4- methvlthiophenvl)-2-methvlthiazole: To a solution of 2-bromo-2- (4-fluorophenyl) -1- (4- methylthiophenyl) ethanone from Step 2 (0.70 g, 2.10 mmol) in ethanol (20 mL) was added thioacetamide (0.16 g, 2.10 mmol) and the mixture was heated to reflux for 20 hours. The reaction was cooled to room temperature and concentrated in vacuo and dissolved in methylene chloride. This solution was washed with NaHC03 saturated solution and dried over a2S04, filtered and reconcentrated in vacuo yielding a white crystalline solid. Flash chromatography of this solid (2:1 methylene chloride:hexane) yielded 5- (4-fluorophenyl) - 4- (4-methylthiophenyl) -2-methylthiazole as a white solid (0.45 g, 68 %) : mp 104-105°C. H NMR (CDCI 3 ) 400 mHz δ 7.39 (d, J = 8.32, 2H) , 7.28 (dd, J = 8.80, 5.14, 2H) , 7.15 (d, J = 8.32, 2H) , 7.00 (t, J = 8.80, 2H) , 2.74 (s, 3H) , 2.47 ( s, 3H) . MS (El) : m/z 316 (M+H) . HRMS Δ = 0.000 mmu. Step 4: Preparation of 5- (4-fluorophenvl) -4- (4- methvlsulfonvlphenvl) -2-methvlthiazole: To a solution of 2- (methyl) -5- (4-fluorophenyl) -4- ( -methylthiophenyl) thiazole from Step 3 (0.440 g, 1.39 mmol) in methylene chloride (15 mL) at 0°C was added MCPBA (0.90 g of 67% peroxide content MCPBA, 3.49 mmol) and the reaction was warmed to room temperature and let stand overnight . The crude reaction mixture was diluted with methylene chloride (70 mL) and the resulting solution was washed successively with NaHS03 solution (0.1 M) and NaHC03 saturated solution, dried over Na2S04, filtered and concentrated in vacuo . The crude product was purified by flash chromatography (1:1 methylene chloride:hexane) and the product thus obtained was recrystallized from methylene chloride and isooctane yielding 5- (4-fluorophenyl) -4- (4- methylsulfonylphenyl) -2-methylthiazole as clear colorless needles (0.274 g, 57%): mp 134-135°C. lH NMR (CDCI 3 ) 400 mHz δ 7.84 (d, J = 8.56 Hz, 2H) , 7.69 (d, J = 8.56 Hz, 2H) , 7.28 (m, 2H) , 7.06 (t, J = 8.68, 2H) , 3.04 (s, 3H) , 2.76 (s, 3H) . MS (El) : m/z 348 (MH+); HRMS Δ = -2.5 mmu. Example 21 2- ( 3- [4-Bromophenyl]propyl) -4- (4- fluorophenyl) ) -5- (4- methylsulfonylphenyl) thiazole Step 1: Preparation of 4- (4-bromophenyl) thiobutvramide: To a solution of 4- (4-bromophenyl)butyramide (1.653 g, 6.827 mmol) in toluene (35 mL) was added Lawesson's reagent (1.381 g, 3.414 mmol). The reaction was heated at reflux overnight, cooled to room temperature, and concentrated yielding an orange oil. Flash chromatography of this oil (1:1 hexane:methylene chloride with 1% acetic acid) yielded 4- (4-bromophenyl) thiobutyramide as off-white needles (0.196 g) : mp 104-105°C. lH NMR (DMSO-d δ ) 300 MHz δ 9.33 (br s, IH) , 9.12 (br s, IH) , 7.44 (d, J = 8.11 Hz, 2H) , 7.14 (d, J = 8.48 H z, 2H) , 2.56-2.41 (m, 4H) , 1.95 - 1.85 (m , 2H) . Step 2: Preparation of 2- (3- ' 4-bromophenvllpropvl) -4- (4-fluorophenyl) ) -5- (4-methvlthiophenvl) thiazol : To a solution of 2-bromo-2- (4-fluorophenyl) -1- (4- methylthiophenyl) ethanone (Example 1, Step 3) (2.70 g, 7.90 mmol) in acetonitrile (90 mL) and ethanol (10 mL) was added 4- (4-bromophenyl) thiobutyramide from Step 1, (1.4 g, 7.90 mmol) and the mixture was heated to reflux for 7 hours. The reaction was cooled to room temperature and let stand overnight . The crude product was concentrated in vacuo yielding an oil which was purified by flash chromatography (1:1 hexane:methylene chloride) yielding 2- (3- [4-bromophenyl]propyl) -4- (4- fluorophenyl) ) -5- (4-methylthiophenyl) thiazole (1.4 g, 36 %) as a clear colorless oil (ca. 90 % purity by ^H NMR) : H NMR (CDCI 3 ) 300 MHz δ 7.50-7.46 (m, 2H) , 7.41 (d, J = 8.46 Hz, 2H) , 7.22 (d, J = 8.66 Hz, 2H) , 7.16 (d, J = 8.66 Hz, 2H) , 7.10 (d, J = 8.26 Hz, 2H) , 6.97 (t, J = 8.86, 2H) , 3.03 (t, J = 7.45 Hz, 2H) , 2.74 (t, J = 7.45 Hz, 2H) , 2.49 (s, 3H) , 2.20 - 2.09 (m, 2H) . MS (El) : m/z 529, 531 (M+) 497, 499. HRMS Δ = -2.1 mmu. Step 3 Preparation of 2- (3- f -bromophenyllpropyl) - 4- (4-fluorophenyl) ) -5- (4- methvlsulfonvlphenvl) thiazole: To a solution of 2- (3- [4-bromophenyl]propyl) -4- (4-fluorophenyl) ) -5- (4-methythiopheny1)thiazole from Step 2 (0.20 g, 0.48 mmol) in methylene chloride (5 mL) at 0°C was added MCPBA (0.17 g of 67% peroxide reagent, 0.65 mmol) and the solution was warmed to room temperature and let stand overnight. The reaction mixture was diluted with methylene chloride (50 mL) , was washed successively with NaHS03 solution (0.1 M) , and NaHC03 saturated solution, dried over Na2S04, filtered and concentrated in vacuo. The product was recrystallized from methylene chloride and isooctane yielding 2- (3- [4-bromophenyl]propyl) -4- (4- fluorophenyl) ) -5- (4-methylsulfonylphenyl) thiazole as a white crystalline solid (0.113 g, 44%) : mp 132-133°C. H NMR (CDCI 3 ) 300 MHz δ 7.86 (d, J = 8.46 Hz, 2H) , 7.49 - 7.40 (m, 6H) , 7.11 - 7.08 (m, 2H) , 7.01 (t, J = 8.66 Hz, 2H) , 3.08 - 3.03 (m, 5H) , 2.75 (t, J = 7.45 Hz, 2H) , 2.18 (m, -2H) . MS (El): m/z 529,5311 (M+) . HRMS Δ = -3.117 mmu. Example 22 4- ( -Fluorophenyl) -5- (4- methylsulfonylphenyl) thiazole Step 1: Preparation of 4- (4-fluorophenvl) )-5- (4- methvlthiophenvl)thiazol : To a solution of formamide (3.4 g, 3.0 mL, 75.5 mmol) in diethyl ether was added, with ice bath cooling and stirring solid, phosphorous pentasulfide (2.35 g, 5.3 mmol) in several portions. The reaction was refrigerated at 5°C for 72 hours, warmed to room temperature and stirred for an additional 16 hours. The ethereal solution of resulting thioformamide was decanted from the reaction mixture and ' used "as is". One half of this ethereal solution was concentrated in vacuo The resulting straw colored oil was diluted with acetonitrile (10 mL) and cooled to 0°C (ice bath). Solid 2-bromo-l- (4-fluorophenyl)-2-(4- methylthiophenyl)ethanone (Example 1, Step 3) (0.518 g, 1.53 mmol) was added and the reaction was stirred at room temperature for 8 days. The reaction mixture was concentrated in vacuo, diluted with methylene chloride and washed successively with NaHC03 saturated solution, and brine, dried over Na2S04, filtered and reconcentrated in vacuo . The crude thiazole was purified by flash chromatography (1:1 hexane:methylene chloride) yielding 4- (4-fluorophenyl) ) -5- (4- methylthiophenyl)thiazole as a clear viscous oil (0.37 g, 80%): H NMR (CDCI3) 300 MHz δ 8.75 (s, IH) , 7.52 (dd, J = 8.87, 5.47 Hz, 2H) , 7.22 (d, J = 8.68, 2H) , 7.17 (d, J = 8.68, 2H) , 6.98 (t, J = 8.87 Hz, 2H) , 2.45 (s, 3H) . MS (El) : m/e 301 (M+) . HRMS Δ = 5.063 mmu. Step 2: Preparation of 4- (4-fluorophenvl) -5- (4- ethvlsulfonvlphenvl) thiazole: To a solution of 4- (4-fluorophenyl) ) -5- (4- methylthiophenyl)thiazole from Step 1 (0.35 g, 1.16 mmol) in methylene chloride (12 mL) at 0°C was added MCPBA (0.75 g of 67% peroxide content reagent, 2.90 mmol) . The solution was warmed to room temperature and stirred overnight. The reaction was diluted with methylene chloride (40 mL) and this solution was successively washed with NaHS03 solution (0.1 M) , and NaHC03 saturated solution, dried over Na2S04, filtered and concentrated in vacuo . The product was recrystallized from methylene chloride and isooctane yielding 4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl)thiazole as long pale yellow needles (0.253 g, 65%) : mp 138-139°C. 3-H NMR (CDCI 3 ) 300 MHz δ 8.89 (s, IH) , 7.91 (d, J = 8.68, 2H) , 7.55 (d, J = 8.68, 2H) , 7.48 (dd, J = 9.06, 5.28Hz, 2H) , 7.03 (t, J = 9.06 Hz, 2 H) , 3.09 (s, 3H) . MS (El) : m/z 333 (M+) . HRMS Δ = -5.342 mmu. Example 23 4- ( 4-Fluorophenyl ) -5- ( 4-methylsulfonylphenyl ) 2-trifluoromethylthiazole Step 1: Preparation of 4- (4-fluorophenvl) -5- (4- • ne h Y lthioph nY3,)-?- r £luoromgthyithi^zoie; To a solution of trifluoroacetamide (13.7 g, 121.2 mmol) in toluene (30 mL) was added solid phosphorous pentasulfide (5.4 g, 12.1 mmol) and the mixture was heated to reflux for 60 hours. The resulting orange "coarse" suspension was cooled to room temperature and pulverized to form a fine suspension. 2-Bromo-l- (4-fluorophenyl) -2- (4- methylthiophenyl)ethanone (Example 1, Step 3) (1.53 g, 4.50 mmol) was added in one portion to the toluene suspension (7.5 mL, ca. 30 mmol of theory) . This suspension was heated to reflux for 1.5 hours, cooled to 50°C, and 1.0 N HCI solution (1 mL) was added carefully. The solution was reheated to reflux for 1 hour more. This reaction was cooled to room temperature and let stand overnight . To this solution was added 2 N NaOH solution until the exotherm subsided and the reaction was stirred for 1 hour longer. The resulting black suspension was diluted with methylene chloride and washed with NaHC03 saturated solution, dried over Na2S04, filtered and concentrated in vacuo yielding an orange oily semi- solid. This crude intermediate was purified by flash chromatography with 3:1 hexanerethyl acetate and 9:1 hexane:methylene chloride yielding 4- (4-fluorophenyl) - 5- (4-methylthiophenyl) -2-trifluoromethylthiazole (1.1 g, 72%) as a pale brown oil: lH NMR (CDCI 3 ) 300 MHz δ 7.52 (dd, J = 5.28, 9.06, 2H) , 7.24 (m, 4H) , 7.01 (t, J = 8.68 Hz, 2H) , 2.51 (s, 3H) . MS (El): m/z 369 (M+H) . HRMS Δ = ^ 1.446 mmu. Step 2: Preparation of 4- (4-fluorophenvl) -5- (4- ethvlsulfonvlphenvl) -2-trifluoromethylthiazole: To a solution of 2-trifluoromethyl-5- (4- fluorophenyl) ) -4- (4-methylthiophenyl)thiazole from Step 1 (1.10 g, 3.30 mmol) in methylene chloride (30 mL) at 0°C was added MCPBA (2.10 g of 67% peroxide content reagent, 8.20 mmol) in three portions over 2 hours. After 3 hours total reaction time, the reaction was diluted with methylene chloride (150 mL) and the solution was washed with NaHS03 solution (0.1 M) :NaHC03 saturated solution (1:1 ration 3x50 mL) , dried over MgS04, filtered and concentrated in vacuo . The resulting solid was recrystallized from methylene chloride and isooctane yielding 4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2-trifluoromethylthiazole as opaque white crystals (1.1 g, 90%) : mp 168-170°C. lH NMR (CDC1 3 ) 300 MHz δ 7.97 (d, J = 8.84, 2H) , 7.57 (d, J = 8.84, J = 8.84, 2H), 7.47 (dd, J = 8.85, J = 5.16, 2H) , 7.04 (t, J = 8.85 Hz, 2H) , 3.11 (s, 3H) ; 1 9 F NMR (CDCI3) 300 MHz δ -61.55, -111.42. MS (El) : m/z 402 (MH+) . HRMS Δ = 1.938 mmu. Example 24 4- (4-Fluorophenyl) -5- (4-methylsulfonylphenyl ) - 2- (2-thienyl) thiazole Step 1: Preparation of 4- (4-fluorophenyl) -5- (4- methvlthiophenvl) -2- (2-thienvl) thiazol : To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylthiophenyl) ethanone (Example 1, Step 3) (0.249 g, 0.734 mmol) in ethanol (9 mL) was added thiophene- 2-thiocarboxamide (0.110 g, 0.771 mmol) and the mixture was heated to reflux 14 hours. The reaction was cooled to room temperature, diluted with ethyl acetate (50 mL) and this solution washed successively with Na2C03 (10 % solution, 3x20 mL) and brine, dried over Na2S04, filtered and concentrated in vacuo yielding an orange crystalline solid. This solid was purified by flash chromatography (9:1 hexane:ethyl acetate) yielding 4- (4-fluorophenyl) -5- (4- methylthiophenyl) -2- (2-thienyl]thiazole (0.228 g, 82%) as a viscous yellow oil: H NMR (CDCI 3 ) 300 MHz δ 7.53-7.58 (m, 3H) , 7.40 (dd, J = 5.29, 1.17 Hz, lH) , 7.28 (d, J = 8.30 Hz, 2H) , 7.19 (d, J = 8.30 Hz, 2H) , 7.09 (dd, J = 4.91, 3.78 Hz, IH) , 7.00 (t, J = 8.68 Hz, 2H) , 2.50 (s, 3H) . MS (El) : m/e 383 (M+) . HRMS Δ = 0.1 mmu. Step 2: Preparation of 4- (4-fluorophenvl) -5- (4- methylsulfonylphenyl) -2- (2-thienvl) hiazole: To a solution of 2- (2-thienyl) -4- (4- fluorophenyl) -5- (4-methylthiophenyl) thiazole from Step 1 (0.20 g, 0.52 mmol) in methylene chloride (5 mL) , MCPBA was added at 0°C ( 0.27 g of 67 % peroxide content MCPBA, 1.1 mmol) and the reaction was warmed to room temperature. The crude reaction mixture was diluted with methylene chloride (50 mL) and the resulting solution was washed successively with NaHS03 solution (0.1 M) , NaHC03 saturated solution and brine, dried over Na2S04, filtered and concentrated in vacuo . The crude product was recrystallized from methylene chloride and isooctane yielding 4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2- (2-thienyl) thiazole as a pale green solid (0.170 g, 79%) : mp 194-195°C. lH NMR (DMSO-d 6 ) 400 MHz δ 7.90 (d, J = 8.30 Hz, 2H) , 7.58 (d, J = 3.91 Hz, IH) , 7.55-7.50 (m, 4H) , 7.45 (d, J = 3.91 Hz, IH) , 7.13-7.11 (m, IH) , 7.04 (t, J = 8.79 Hz, 2H) , 3.09 (ε, 3H) . ' MS (El) : m/z 416 (MH+) . HRMS Δ = 0.9 mmu. Example 25 2- ( 5-Bromo-2-thienyl ) -4- ( 4-fluorophenyl ) -5- ( 4- methylsulfonylphenyl) thiazole To a solution of 4- (4-fluorophenyl) -5- (4- methylthiophenyl) -2- (2-thienyl]thiazole (Example 24, Step 1) (0.057 g, 0.149 mmol) suspended in acetic acid (2 mL) and methylene chloride (2.0 mL) was added excess bromine in acetic acid (1.4 M, 0.51 mL, 0.714 mmol) . The reaction was concentrated in vacuo, diluted with ethyl acetate, and washed successively with NaHS03 solution (0.1 M) , NaHC03 saturated solution and brine, dried over Na2Sθ4, filtered and reconcentrated in vacuo . The resulting compound was diluted with methylene chloride (1 mL) and MCPBA (0.064 g of 67% peroxide reagent, 2.48 mmol) and let stand for 4 hours. The crude reaction mixture was diluted with methylene chloride (50 mL) and the resulting solution was washed successively with NaHS03 solution (0.1 M) , NaHC03 saturated solution and brine, dried over Na2S04, filtered and again concentrated in vacuo. The crude product was recrystallized from methylene chloride and isooctane yielding 2-(5-bromo- 2-thienyl) -4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl) -thiazole as fine yellow needles (0.039 g, 53 %) : mp 190-191°C. l H NMR (CDC1 3 ) 300 MHz δ 7.89 (d, J = 8.46 Hz, 2H) , 7.54 (d, J = 8.46 Hz, 2H) , 7.49 (m, 2H) , 7.30 (d, J = 4.03 Hz, IH) , 7.08 (m IH) , 7.04 (t, J = 8.66 Hz, 2H) , 3.09 (s, 3H) . MS (El) : m/z 496 (M+H) . Example 26 4- ( 4-Fluorophenyl ) -5- (4-methylsulfonylphenyl ) - 2- ( 3-pyridyl ) thiazole Step 1: Preparation of 1- (4-fluorophenvl) -2- (4- methvlsulfonvlphenvl) ethanone: To a stirred solution of 1- (4-fluorophenyl) -2- (4- methylthiophenyl)ethanone (Example 1, Step 3) (15.00 g, 57.62 mmol) in methylene chloride (500 mL) at 5°C (ice-bath) was added MCPBA (29.64 g, ca. 67% peroxide, ca. 113 mmol), portionwise over 30 minutes. The solution was warmed to room temperature. The reaction solution was stirred vigorously with NaHS03 solution for 10 minutes to quench any unreacted MCPBA. The layers were separated and ethyl acetate was added to aid in dissolution of the precipitate which began to form. The partial suspension was filtered and the solid saved. The organic phase was washed successively with NaHC03 solution and brine, dried over Na 2 S0 4 , and diluted with isooctane until a solid began to precipitate. More solid precipitated upon removal of most of the solvent in vacuo . All of the precipitates were combined yielding l-(4- fluorophenyl) -2- (4-methylsulfonylphenyl)ethanone (14.5 g, 86 %) . mp 182-183°C. lH NMR (CDCI 3 ) 300 MHz δ 8.04 (dd, J = 5.24, 8.46, 2H) , 7.92 (d, J = 8.26 Hz, 2H) , 7.46 (d, J = 8.46 Hz, 2H) , 7.17 (t, J = 8.46, 2H) , 4.37 (s, 2H) , 3.05 (s, 3H) . MS: m/z 293 (MH+) ; HRMS Δ = 1.6 mmu. Step 2 : Preparation of 2-bromo-1-( -fluorophenyl) -2- (4-methvlsulfonvlohenvl)ethanone: To a stirred slurry of 1- (4-fluorophenyl) -2- (4- methylsulfonylphenyl) ethanone from Step 1 (3.03 g, 10.38 mmol) in acetic acid (40 mL) was added HBr in acetic acid (2 mL, 48% by wt . ) and bromine (0.64 mL, 1.99 g, 12.45 mmol) . Within minutes the slurry became homogeneous. After 1 hour, the reaction was concentrated in vacuo , diluted with methylene chloride and reconcentrated in vacuo yielding 2-bromo-l- (4- fluorophenyl) -2- (4-methylsulfonylphenyl) ethanone as a tan solid (3.53 g, 95 %) which could be used without further purification: mp 140-141°C, lH NMR (CDCI 3 ) 300 MHz δ 8.05 (dd, J = 5.16, 8.84 Hz, 2H) , 7.96 (d, J = 8.48 Hz, 2H) , 7.75 (d, J = 8.48 Hz, 2H) , 7.17 (t, J = 8.48 Hz, 2H) , 6.29 (s, IH) , 3.06 ( s, 3H) . MS: m/e 371/373 (MH+) . HRMS Δ = 5.5 mmu. Step 3: Preparation of 4- (4-fluorophenvl) -5- (4- methvlsulfonvlphenvl) -2- (3-pvridvl) thiazole: To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylsulfonylphenyl)ethanone from Step 2 (0.732 g, 1.97 mmol) in acetonitrile (20 mL) was added thionicotinamide ( 0.273 g, 1.97 mmol) with stirring. The resulting solution was heated to reflux for 1 hour and additional 2-bromo-l- (4-fluorophenyl) -3- (methylsulfonylphenyl) ethanone (0.031 g, 0.05 mmol) was added and stirred at reflux for an additional hour. The reaction was cooled to room temperature and concentrated in vacuo yielding an orange semi-solid. This was purified by flash chromatography (2:1 hexane:ethyl acetate with 1% acetic acid) . The product fractions were combined, toluene added, and the resulting solution reconcentrated in vacuo yielding 4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2- (3- pyridyl) thiazole as a pale yellow crystalline solid (0.351 g, 43%) : mp 143-146°C. lH NMR (CDCI3) 400 MHz δ 9.20 (d, J = 1.81 Hz, lH) , 8.68 (dd, J = 1.46, 4.89 Hz, IH) , 8.30 (dt, J = 2.00, 9.42 Hz, IH) , 7.91 (d, J = 8.55 Hz, 2H) , 7.60-7.52 (m, 4H) , 7.42 (m, 1), 7.05 (t, J = 8.70 Hz, 2H) , 3.10 (s, 3H) . MS (El) : m/z 410 (M+) . HRMS Δ = -4.3 mmu. Example 27 2- (Cyanomethyl) -4- ( -fluorophenyl) -5- ( 4- methylsulfonylphenyl) thiazole Step 1: Preparation of 2- (cvanomethvl ) -4- (4- fluorophenvl) -5- (4-methvlthiophenvl) thiazole: To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylsulfonylphenyl)ethanone (Example 26, Step 2) (0.249 g, 0.734 mmol) in ethanol (9 mL) was added 2- cyanothioacetamide (0.077 g, 0.771 mmol) and the solution was heated to reflux for 14 hours. The reaction was cooled to room temperature, was concentrated in vacuo and the residue was dissolved in ethyl acetate. This solution was washed successively with Na2C03 (10% solution) and brine, dried over Na2S04, filtered and reconcentrated in vacuo yielding an orange crystalline solid. The solid was purified by flash chromatography (4:1 hexane:ethyl acetate) yielding 2- (cyanomethyl) -4- (4-fluorophenyl) -5- (4- methylthiophenyl) thiazole as very fine pink crystals (0.090 g, 36%) : mp 118-119°C. H NMR (CDCI3) 400 MHz δ 7.50 (d, J = 5.38, 2H) , 7.47 (d, J = 5.38, 2H) , 7.24-7.18 (m, 4H) , 7.00 (t, J = 8.80, 2H) , 4.16 (s, 2H) , 2.50 (s, 3H) . MS (El) : m/z 340 (M+) . HRMS Δ = 2.7 mmu. Step 2: Preparation of 2- (cvanomethvl) -4- (4- fluorophenyl) -5- (4-methvlsulfonvlohenvl) hiazole: To a solution of 2-cyanomethyl-4- (4- fluorophenyl) -5- (4-methylthiophenyl) thiazole from Step 1 (0.08 g, 0.24 mmol) in methylene chloride (3 mL) at 0°C was added MCPBA (0.13 g of 67 % peroxide content MCPBA, 0.48 mmol) and the reaction was warmed to room temperature. The crude reaction mixture was diluted with methylene chloride (50 mL) , washed successively with NaHS03 solution (0.1 M) , NaHC03 saturated solution, and brine, dried over Na2S04, filtered and concentrated in vacuo. The crude product was recrystallized from methylene chloride and isooctane yielding 2- (cyanomethyl) -4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl)thiazole as light orange needles (0.064 g, 72%) : mp 151-152°C. lH NMR (CDCI3) 400 MHz δ 7.92 (d, J = 8.79, 2H) , 7.52 ( d, J = 8.79, 2H) , 7.44 (m, 2H) , 7.03 (t, J = 8.30, 2H) , 4.17 (s, 2H) , 3.09 (s, 3H) . MS (El) : m/z 373 (M+H) . HRMS Δ = 4.8 mmu. Example 28 4 - ( 4 -Fluorophenyl ) -5- ( 4 -methylsulf onylphenyl ) - 2-methylthiazole To a solution of 2-bromo-l- (4-f luorophenyl) -2- (4- methylsulf onylphenyl) ethanone (0.437 g, 1.18 mmol) (Example 26, Step 2) in acetonitrile (10 mL) was added thioacetamide (0.088 g, 1.18 mmol) and the solution was heated to reflux (2 hours) until all solid dissolved. The reaction was cooled to room temperature. The acetonitrile was removed in vacuo and the resulting product precipitated from methanol by the addition of water yielding 4- (4-fluorophenyl)- 5- (4-methylsulfonylphenyl) -2-methylthiazole (0.226 g, 55 %, ca. 85% purity by lH NMR): mp 229-233°C. lH NMR (CDCI3) 300 MHz δ 7.98 (d, J = 8.11 Hz, 2H ), 7.66-7.61 (m, 2H) , 7.52 (d, J = 8.48 Hz, 2H) , 7.13 (t, J = 8.48 Hz, 2H) , 3.31 (s, IH) , 3.10 ( s, 3H) . MS (EI- thermospray) : m/z 348 (M+) . HRMS Δ = -2.3 mmu. Example 29 4- (4-Fluorophenyl) -5-(4-methylsulfonylphenyl) - 2-benzylaminothiazole To a solution of 2-bromo-l- (4-fluorophenyl)-2- (4- methylsulfonylphenyl)ethanone (Example 26, Step 2) (0.415 g, 1.12 mmol) in isopropanol (12 mL) was added N-benzyl thiourea (0.186 g, 1.12 mmol). The solution was heated to reflux (30 hours) , cooled to room temperature and let stand for 7 days. The resulting suspension was concentrated in vacuo . The resulting residue was suspended in methylene chloride (100 mL) and washed with NaHCθ3 saturated solution (3x10 mL) , dried over sodium sulfate, filtered and reconcentrated in vacuo yielding 4- (4-fluorophenyl)-5- (4- methylsulfonylphenyl) -2-benzylaminothiazole as a pale yellow solid (0.34 g, 69%) : mp 112°C. lH NMR (CDCI 3 ) 400 MHz δ 7.74 (d, J = 8.56 Hz, 2H) , 7.43-7.25 (m, 10H) , 6.92 (t, J = 8.56 Hz, 2H) , 4.33 (s, 2H) , 3.02 (s, 3H) . MS (El-thermospray) : m/z 439 (MH+) . HRMS Δ = 1.6 mmu. Example 30 4- ( 4-Fluorophenyl) -5- (4-methylsulfonylphenyl ) 2- (1-piperidinyl) thiazole To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylsulfonylphenyl)ethanone (0.462 g, 1.24 mmol) (Example 26, Step 2) in ethanol (10 mL) was added piperidine thiocarboxamide (0.198 g, 1.37 mmol) and the solution was heated to reflux for 14 hours. The reaction was cooled to room temperature and concentrated in vacuo yielding a foam. This foam was dissolved in methylene chloride and washed successively with NaHC03 saturated solution (3 portions) and brine, dried over Na2S04, filtered and reconcentrated in vacuo yielding 4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2- (1-piperidinyl) -thiazole (0.371 g, 72%) as a yellow-green fluffy solid: mp 173-175°C, lH NMR (CDCl 3 ) 400 MHz δ 7.77 (d, J = 8.56 Hz, 2H) , 7.46 (dd, J = 5.60, 8.80), 7.38 (d, J = 8.56 Hz, 2H) , 6.99 (t, J = 8.80 Hz, 2H) , 3.53 (s (broad), 4H) , 3.05 (s, 3H) , 1.70 (s (broad), 6H) . MS (El) : m/z 417 (MH+) . HRMS Δ = -1.5 mmu. Example 31 4- ( 4-Fluorophenyl) -5- (4-methylsulfonylphenyl ) - 2- ( 1-propylamino) thiazole To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylsulfonylphenyl) ethanone (0.346 g, 0.932 mmol) (Example 26, Step 2) in ethanol (15 mL) was added N- propylthiourea (0.116 g, 0.979 mmol) with stirring. The resulting solution was heated to reflux for 24 hours. The reaction was cooled to room temperature and concentrated in vacuo. The residue was dissolved in methylene chloride, washed successively with Na2C03 (10 % solution) and brine, dried over Na2S04, filtered and reconcentrated in vacuo yielding 4- (4- fluorophenyl) -5- (4-methylsulfonylphenyl) -2- (1- propylamino) thiazole as a yellow crystalline solid (0.276 g, 76 %) : mp 181-182°C. lH NMR (DMSO-dβ) 400 MHz δ 7.97 (t, J = 5.37 Hz, IH) , 7.78 (d, J = 8.79 Hz, 2H), 7.42 (dd, J = 5.86, 8.79, 2H) , 7.37 (d, J = 8.79, 2H) , 7.15 (t, J = 8.79 Hz, 2H) , 3.21 (q, J = 6.84, 2H) , 3.18 (s, 3H), 1.60 (m, 2H) , 0.91 (t, J = 7.33, 3H) . MS (El) : m/z 390 (M+) . HRMS Δ = 2.4 mmu. Example 32 4- [4- ( 4-Fluorophenyl) -2- (2-chlorophenyl ) -5- thiazolyl]benzenesulfonamide To a solution of the methyl sulfone (Example 16) (0.21 g, 0.47 mmol) in tetrahydrofuran (THF) (5 mL) at 0°C under nitrogen was added 2 M n-butyl magnesium chloride in THF (1.0 mL, 2.0 mmol) slowly, via syringe, and the mixture was stirred at 0°C for 30 minutes and then at room temperature (25°C) for 2 hours. After cooling to 0°C, a 1.0 M solution of triethyl borane in THF (2.5 mL, 2.5 mmol) was added and the mixture was warmed to room temperature and stirred for 2 hours, and then heated to reflux overnight (18 hours) . After cooling to room temperature for 3 hours, water (3 mL) was added followed by sodium acetate (1.2 g) and hydroxylami e- O-sulfonic acid (0.82 g) . After stirring at room temperature overnight, the mixture was poured into 3 volumes of ethyl acetate, and the organic layer washed with water and brine and dried over MgS04. After solvent removal, the white solids (a mixture of product and starting material) was recrystallized from ethyl acetate/hexane to provide 0.11 g of a white solid. Anal. Calc'd for C21H14 2O2S2FCI: C, 56.69; H,. 3.17; N, 6.30. Found: C, 55.99; H, 2.97; N, 6.15. Example 33 2- [ ( 3 , 5-Dichlorophenoxy)methyl) -4- ( 4- fluorophenyl ) -5- [4- (methylsulfonyl) phenyl] thiazole Step 1: Preparation of 2- ((3.5- dichlorophenoxv)methvl) -4- (4-fluorophenvl ) -5- (4- methvlthiophenvl)thiazole: A solution of 1- (4-fluorophenyl) -2- (4- methylthiophenyl) -2-bromoethanone, (Example 1, Step 3) (4.01 g, 11.8 mmol) and 3, 5-dichlorophenoxy thioacetamide (2.80 g, 11.9 mmol) in 20 mL of acetonitrile and 10 mL of ethanol was heated to reflux for 1.2 hours. The solution was diluted with methanol, cooled to 0°C in an ice bath and a precipitate formed that was removed by filtration to provide pure 4- (4-fluorophenyl) -5- (4- methylthiophenyl) -2- ( (3,5- dichlorophenoxy) ethyl) thiazole (4.19 g; 74%) which was used directly in the next step: mp 104.5-105.0°C; Mass spectrum M+H=476. Step 2: Preparation of 2-H3.5- dichlorophenoxv)methvl) -4- (4-fluorophenvl) -5- (4- methvlsulfonvlphenvl) hiazole: A dichloromethane (30 mL) solution of the thiazole from Step 1 (4.06 g, 8.52 mmol) was treated with /n-chloroperoxybenzoic acid (5.98 g, 17.06 mmol) and stirred at room temperature for 0.75 hour. The solution was washed successively with 10% aq. NaHS0 3 , 10% Na 2 Cθ 3 , dried over anhydrous MgS0 4 , filtered and concentrated in vacuo to give a white solid. Recrystallization from a mixture of dichloromethane and isooctane afforded 2.50 g (58%) of pure 2- ((3,5- dichlorophenoxy) ethyl) -4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl) thiazole as a white solid: mp 171-173°C; X H NMR (CDCI 3 ) 300 MHz 7.88 (d, J= 8.5Hz, 2H) , 7.54 (d, J= 8.5Hz, 2H) , 7.50-7.40 (m, 2H) , 7.07- 6.90 (m, 5H) , 5.37 (s, 2H) , 3.08 (s, 3H) ; 19 F NMR (CDCI 3 ) 112.53 (m) . High resolution mass spectrum Calc'd. for C23H 1 6CIFNO3S 2 (MH + ) : 506.9933. Found: 506.9932. Example 34 4- [2- ( ( 3 , 5-Dichlorophenoxy) ethyl ) -4- ( - fluorophenyl ) -5-thiazolyl]benzenesulfonamide To a solution of 2- ( (3 , 5-dichlorophenoxy)methyl) - 4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) thiazole (Example 33) (0.508 g, 1.0 mmol) in THF (5 mL) at 0°C under nitrogen was added 2.0 M n-butyl magnesium chloride in THF (1.6 mL, 3.2 mmol) slowly, via syringe, and the mixture stirred at 0°C for 30 minutes and then at room temperature (25°C) for 2 hours. After cooling to 0°C, a 1.0 M solution of triethyl borane in THF (5 mL, 5 mmol) was added and the mixture was warmed to room temperature and stirred for 2 hours, and then heated to reflux for 36 hours. After cooling to room temperature and stirring for 3 hours, water (3 mL) was added followed by sodium acetate (1.2 g) and hydroxylamine-O-sulfonic acid (0.82 g) . After stirring at room temperature overnight, the mixture was poured into 3 volumes of ethyl acetate, and the organic layer washed with water and brine and dried over MgS0 4 . After solvent removal, the white solids (a mixture of product and starting material) were purified by flash chromatography on silica gel using 30% ethyl acetate/70% hexane to provide 4- [4- (4-fluorophenyl) -2- ( (3 , 5-dichlorophenoxy)methyl) -5- thiazolyl]benzenesulfonamide as a white solid (0.147 g) : Anal. Calc'd for C 2 2H 15 N 2 O 3 S 2 FCI 2 : C, 51.87; H, 2.97; N, 5.50. Found: C, 52.19; H, 2.84; N, 5.40 . Example 35 2- (2-Chlorophenyl) -4- (2-fluorophenyl) -5- (4- methylsulfonylphenyl) thiazole Step 1: Preparation of 2- (2-fluorophenvl) -3- (4- wethYlthiophenyDpropenoic acid; Acetic anhydride (60 mL) , 4- (methylthio)benzaldehyde (7.05 g, 44 mmol), 2- fluorophenylacetic acid (7.79 g, 50.5 mmol), and triethylamine (5.50 g, 54.5 mmol) were heated to reflux for 1.75 hours. The reaction was cooled to 90°C, and water (100 mL) was added cautiously. This caused the solution to reflux vigorously and the temperature to rise to 135°C. A yellow precipitate formed and after cooling to room temperature the solid was collected by filtration, washed with water, and recrystallized from toluene to provide 2- (2- fluorophenyl) -3- (4-methylthiophenyl)propenoic acid as yellow needles (7.98 g, 63%) : mp 151.5-156.0°C. 1H NMR (CDCI3) 300 MHz 8.01 (s, IH) , 7.41-7.00 (m, 8H) , 2.43 (s, 3H) . 19F NMR (CDCI3) -113.40 (m) . Mass spectrum M+H+=289. Step 2: Preparation of 1- (2-fluorophenvl) -2- (4- methylthiophenvl)ethanone: A solution of 2- (2-fluorophenyl) -.3- (4- methylthiophenyDpropenoic acid from Step 1 (7.86 g, 27.3 mmol) and triethylamine (2.80 g, 27.7 mmol) in 22 mL of anhydrous toluene was cooled to 0°C and treated with diphenylphosphoryl azide (7.73 g, 28.1 mmol) . The solution was stirred at 0°C for 20 minutes and at room temperature for 3.50 hours. The reaction was poured into water, extracted with ether, dried over magnesium sulfate, and concentrated in vacuo to remove the ether. The remaining toluene solution was heated to reflux and a vigorous evolution of gas occurred. After 0.75 hours, 11 mL of tert-butyl alcohol was added to the reaction. After an additional twenty minutes, concentrated hydrochloric acid (5 mL) was added slowly and the reaction was heated at 90 °C overnight (14 hours) . The solution was cooled to room temperature and diluted with ethyl acetate, washed with saturated aqueous NaHC03, brine, dried over anhydrous MgS04, filtered and concentrated in vacuo to provide a brown solid that was purified by crystallization from ether to afford l-{2- fluorophenyl) -2- ( -methylthiophenyl)ethanone as a yellow solid (4.60 g, 65%) : mp 58-59.5°C. 1H NMR (CDCI3) 300 MHz 7.84 (m, IH) , 7.52 (m, lH) , 7.23-7.08 (m, 6H) , 4.25 (d, J=2.6Hz, 2H) , 2.46 (s, 3H) . 19F NMR (CDCI3) -108.51 (m) . Mass spectrum M+H+=261. Step 3: Preparation of 1- (2-fluorophenvl) -2- (4- methvlthiophenvl)-2-bromo-ethanone: 1- (2-Fluorophenyl) -2- (4-methylthiophenyl) ethanone from Step 2 (4.36 g, 16.7 mmol) was added to acetic acid (30 mL) and 33% HBr in acetic acid (0.5 mL) . The solution was stirred and treated with bromine (17 mL, 16.8 mmol, 1.0 M in acetic acid) from the addition funnel at such a rate that the bromine color was discharged rapidly, ca. 15 min. After an additional 50 minutes at room temperature, the solution was concentrated in vacuo to give a brown oil. The crude haloketone was dissolved in dichloromethane and washed with IN NaHS03, dried over anhydrous MgS04, filtered and concentrated in vacuo to give 1- (2-fluorophenyl) - 2- (4-methylthiophenyl) -2-bromo-ethanone as an oil that solidified upon standing (4.83 g, 85%) : mp 58-63°C. lH NMR (CDCI3) 300 MHz 7.87 (td, J=7.6, 1.8Hz, IH) , 7.52 (m, IH) , 7.39 (d, J=8.3Hz, 2H) , 7.27-7.03 (m, 4H), 6.34 (s, IH) , 2.45 (s, 3H) . 19F NMR (CDCI3) -108.51 (m) . Mass spectrum M+=338. Step 4: Preparation of 2- (2-chlorophenvl) -4- (2- fluorophenvl) -5- (4-methvlthiophenvl) thiazole: A solution of 1- (2-fluorophenyl) -2- (4- methylthiophenyl) -2-bromo-ethanone from Step 3 (1.39 g, 4.1 mmol) and 2-chlorothiobenzamide (0.71 g, 4.1 mmol) in 10 mL of ethanol was heated to reflux for 4.4 hours. The solution was cooled to room temperature and poured into 25 mL of methanol, and chilled with an ice bath whereupon crystals of pure product formed which were isolated by filtration and air dried to afford the thiazole (1.34 g, 79%) : mp 117-119°C. lH NMR (CDCI3) 300 MHz 8.37 (m, lH) , 7.62 (m, 2H) , 7.49 (d, J=7.7Hz,lH), 7.32 (m, 7H) , 7.22 (d, J=8.5Hz, 2H) , 2.51 (ε, 3H) . Mass spectrum M++H =412. Step 5: Preparation of 2- (2-chlorophenyl) -4- (2- fluorophenvl) -5- (4-methylsulfonylphenyl) thiazole: A solution of 2- (2-chlorophenyl) -4- (2- fluorophenyl) -5- (4-methylthiophenyl) thiazole (1.12 g, 2.72 mmol) in 20 mL of dichloromethane was treated with ffi-chloroperoxybenzoic acid (1.91 g, 5.53 mmol) at 0°C for 20 minutes. The solution was washed with 10% aqueous NaHS03, 10% Na2C03 , dried over anhydrous MgS04, filtered and concentrated in vacuo to give a yellow solid that was purified by recrystallization from a mixture of dichloromethane and isooctane to provide 660 mg (55%) of pure product: mp 163-166°C. lH NMR (CDCI3) 300 MHz 8.37 (m, IH) , 7.86 (d, J=8.5Hz, 2H) , 7.63 (td, J=7.7, 1.8Hz, 2 H) , 7.53 (d, J=8.5Hz, 2H) , 7.53 (m, IH) , 7.38 (m, 3H) , 7.26 (t, J=7.4Hz, IH) , 7.05 (t, J=9.6Hz, IH) , 3.06 (s, 3H) . 19F NMR (CDCI3) -113.33 (m) . High resolution mass spectrum Calc'd. for C22H15CIFNO2S2 : 443.0217. Found: 443.0176. Example 36 2- ( 3-Chlorophenoxy)methyl-4- ( 2-fluorophenyl ) -5- [4- (methylsulfonyl) henyl] thiazole Step 1: Preparation of 2- ( ( -chlorophenoxy)methvl ) -4- (2-fluorophenyl) -5- (4-methvlthiophenv ) thiazole: A solution of 1- (2-fluorophenyl) -2- (4- methylthiophenyl) -2-bromo ethanone, (1.64 g, 4.8 mmol) (Example 34, Step 3) and 3-chlorophenoxy thioacetamide (0.98 g, 4.8 mmol) in 25 mL of acetonitrile was heated to reflux for 14 hours. The solution was diluted with methanol, cooled to 0°C in an ice bath and a precipitate formed that was removed by filtration to provide pure 2- ( (3-chlorophenoxy)methyl)-4- (2- fluorophenyl) -5- (4-methylthiophenyl)thiazole (0.69 g; 32%) . The filtrate was concentrated in vacuo, and the residue dissolved in ethyl acetate, washed with water, brine, dried over anhydrous MgSθ4, filtered and concentrated in vacuo to provide additional product that was crystallized from a mixture of dichloromethane and isooctane to provide 200 mg of additional material for a total yield of 890 mg (42%) : mp 115-118°C: 1H NMR (CDCI3) 300 MHz 7.52-6.90 (m, 12H) , 5.38 (s, 2H) , 2.46 (s, 3H) . 19F NMR (CDCI3) -113.61 (m) . High resolution mass spectrum Calc'd. for C23H17CIFNOS2 (M+): 441.0424. Found: 441.0467. Step 2: Preparation of 2-( (3-chlorophenoxy)methyl)-4- (2-fluorophenyl)-5- (4-methylsulfonylphenyl)thiazple; A dichloromethane (5 mL) solution of 2-((3- chlorophenoxy)methyl)-4- (2-fluorophenyl)-5- (4- methylthiophenyl)thiazole from Step 1 (0.85 g, 1.9 mmol) was treated with m-chloroperoxybenzoic acid (1.33 g, 3.9 mmol) and stirred at room temperature for 15 hours. The solution was washed with 10% aq. NaHS03, 10% Na2C03, dried over anhydrous MgS04, filtered and concentrated in vacuo to give a white solid that was recrystallized from a mixture of dichloromethane and isooctane to afford 0.71 g (78%) of pure 4- (2-fluorophenyl) -5- (4-methylsulfonylphenyl) - 2- ( (3-chlorophenoxy)methyl)thiazole as a white solid: mp 151.5-153°C. lH NMR (CDCI3) 300 MHz 7.84 (d, J=8.3Hz, 2H) , 7.50 (m, IH) , 7.46 (d, J=8.3Hz, 2H) , 7.39 (m, IH) , 7.24 (m, 2H) , 7.06 (m, 3H) , 6.92 (m, IH) , 5.41 (s, 2H) , 3.06 (s, 3H) . 19p NMR (CDCI3) -113.64 (m) . High resolution mass spectrum Calc'd. for C23H17CIFNO3S2 (MH+) : 473.0322. Found: 473.0346. 2- ( ( 3-Chlorophenoxy)methyl ) -4- ( 4-fluorophenyl ) - 5- ( 4-methylsulfonylphenyl ) thiazole Step 1: Preparation of 2- ( ( -chlorophenoxy)methvl) -4- (4-fluorophenyl) -5- (4-methvlthiophenvl)thiazole: A solution of 1- (4-fluorophenyl) -2- (4- methylthiophenyl) -2-bromo-ethanone (1.98 g, 5.84 mmol) (Example 1, Step 3) and 3-chlorophenoxy thioacetamide (1.18 g, 5.85 mmol) in 15 mL of acetonitrile and 10 mL of ethanol was heated to reflux for 16 hours. The solution was diluted with methanol, cooled to 0°C in an ice bath and a precipitate formed that was removed by filtration. The solid was air dried and recrystallized from methanol to provide (1.67 g; 65%),of pure 2- ( (3-chlorophenoxy)methyl) -4- (4- fluorophenyl) -5- (4-methylthiophenyl) thiazole: mp 106- 110°C, lH NMR (CDCI3) 300 MHz 7.50 (m, 2H) , 7.30-7.15 (m, 5H) , 7.09-6.87 (m, 5H) , 5.38 (s, 2H) , 2.50 (s, 3H) . !9F NMR (CDCI3) -113.58 (m) . Mass spectrum M+= 441. Step 2: Preparation of 2- ( (3-chlorophenoxy)methvl) -4- (4-fluorophenyl) -5- (4-methylsulfonvlphenvl) thiazole: A dichloromethane (10 mL) solution of 2-((3- chlorophenoxy)methyl) -4- (4-fluorophenyl) -5- (4- methylthiophenyl) thiazole (0.65 g, 1.47 mmol) was treated with ff i-chloroperoxybenzoic acid (1.03 g, 2.98 mmol) and stirred at room temperature for 1.2 hours. The solution was washed with 10% aq. NaHS03, 10% Na2C03, dried over anhydrous MgS04, filtered and concentrated in vacuo to give a white solid that was recrystallized from dichloromethane to afford 0.50 g (72%) of pure 2- ( (3-chlorophenoxy)methyl) -4- (4- fluorophenyl) -5- (4-methylsulfonylphenyl)thiazole as a white solid: mp 128.5-131°C 3-H NMR (CDCI3) 300 MHz 7.89 (d, J=8.1 Hz, 2H) , 7.52 (d, J=8.lHz, 2H) , 7.46 (m, IH) , 7.25 (t, J=8.5Hz, IH) , 7.03 (m, 3H) , 6.95 (m, IH) , 5.39 (s, 2H) , 3.08 (s, 3H) . 1 F NMR (CDCI3) -112.43 (m) . Mass spectrum M+H+= 474. Example 38 2- ( (2-Chlorophenoxy)methyl) -4- ( -fluorophenyl) - 5- (4-methylsulfonylphenyl)thiazole Step 1: Preparation of 2- ( (2-chlorophenoxy)methvl) -4- (4-fluorophenvl) -5- (4-methvlthiophenvl)thiazol : A solution of 1- (4-fluorophenyl)-2- (4- methylthiophenyl) -2-bromo-ethanone (2.05 g, 6.04 mmol) (Example 1, Step 3) and 2-chlorophenoxy thioacetamide (1.21 g, 6.0 mmol) in 30 mL of acetonitrile was heated to reflux for 3 hours. The solution was diluted with methanol, cooled to 0°C in an ice bath and a precipitate formed that was removed by filtration. The crude solid was further purified by flash chromatography over silica gel and the appropriate fractions were combined, concentrated in vacuo and crystallized from methanol to provide 2.60 g (98%) of pure 4-2- ( (2-chlorophenoxy)methyl) -4- (4-fluorophenyl) - 5- (4-methylthiophenyl) thiazole: mp 126-129°C, 3-H NMR (CDCI3) 300 MHz 7.55-7.39 (m, 4H) , 7.28-6.90 (m, 8H) , 5.44 (s, 2H) , 2.49 (s, 3H) . 19F NMR (CDCI3) -114.00 (m) . Mass spectrum M+H+= 442. Step 2: Preparation of 2- ( (2-chlorophenoxy) ethvl) -4- (4-fluorophenyl) -5- (4-methvlsulfonvlphenvl) hiazole: A dichloromethane (50 mL) solution of 2-((2- chlorophenoxy)methyl) -4- (4-fluorophenyl) -5- (4- methylthiophenyl) thiazole from Step 1 (2.65 g, 6.0 mmol) was treated with in-chloroperoxybenzoic acid (4.19 g, 12.1 mmol) and stirred at room temperature for 3 hours. The solution was washed with 10% aq. NaHS03 , 10% Na2C03, dried over anhydrous MgS04, filtered and concentrated in vacuo to give a white solid that was purified by flash chromatography (silica gel) eluting with hexane/ethyl acetate to afford 2.08 g (73%) of pure 2-((2- chlorophenoxy)methyl) -4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl) thiazole as a white solid, after concentration of the appropriate fractions: mp 189- 191°C lH NMR (CDCI3) 300 MHz 7.89 (d, J=8.5 Hz, 2H) , 7.53 (d, J=8.5Hz, 2H) , 7.50-7.47 (m, 3H) , 7.23 (m, IH) , 7.10-6.95 (m, 4H) , 5.47 (s, 2H) , 3.08 (s, 3H) . 19F NMR (CDCI3) -112.75 (m) . High resolution mass spectrum Calc'd. for C23H17CIFNO3S2: 473.0322. Found: 473.0374. Example 39 4- (4-Fluorophenyl ) -5- [4- (methylsulfonyl) phenyl] -2- (2-methyl-4- thiazolyl) thiazole Step 1: Preparation of 4- (4-fluorophenvl) -5- (4- methvlthiophenvl) -2- T2- (methvl) -4-thiazolyllthiazole: A solution of 1- (4-fluorophenyl) -2- (4- methylthiophenyl) -2-bromoethanone (9.69 g, 28.6 mmol) (Example 1, Step 3) and 2-methylthiazole-4- thiocarboxamide (3.90 g, 24.7 mmol) in 35 mL of acetonitrile and 20 mL of ethanol was heated to reflux for 1 hour. The solution was concentrated in vacuo and the residue was dissolved in ethyl acetate, washed with saturated aqueous NaHC03 , brine, dried over anhydrous MgS04, filtered and concentrated in vacuo to give a yellow solid. The crude solid was purified by flash chromatography over silica gel eluting with 1:1 hexane:ethyl acetate. The appropriate fractions were combined and the solvent removed in vacuo to provide pure 4- (4-fluorophenyl) -5- (4-methylthiophenyl) -2- [2- (methyl) -4-thiazolyl]thiazole (4.79 g; 49%) : mp 132.5-135°C. lH NMR (CDCI3) 300 MHz 7.89 (s, IH) , 7.55 (m, 2H) , 7.25 (d, J=8.5Hz, 2H) , 7.17 (d, J=8.5Hz, 2H) , 7.01 (t, J=8.8Hz, 2H) , 2.78 (s, 3H) , 2.49 (s, 3H) . 19F NMR (CDCI3) -113.80 (m) . Mass spectrum M+H+= 399. Step 2: Preparation of 4- (4-fluorophenvl) -5- (4- methvlsulfonvlphenvl) -2- \2 - (methvl) -4- thiazolvl1 thiazole: A dichloromethane (15 mL) solution of 4- (4- fluorophenyl) -5- (4-methylthiophenyl) -2- [2- (methyl) -4- thiazolyl] thiazole from Step 1 (0.71 g, 1.78 mmol) was treated with ffi-chloroperoxybenzoic acid (1.25 g, 3.62 mmol) and stirred at room temperature for 2 hours. The solution was washed with 10% aq. NaHS03 , 10% Na2C03, dried over anhydrous MgS04, filtered and concentrated in vacuo to give a white solid that was purified by crystallization from a mixture of dichloromethane and isooctane to afford pure 4- (4- fluorophenyl) -5- (4-methylsulfonylphenyl) -2- [2- (methyl)thiazol-4-yl]thiazole (0.37 g, 48%) as a white solid: mp 184-185.5°C. 1H NMR (CDCI3 ) 300 MHz 7.93 (s, IH) , 7.88 (d, J=8.5Hz, 2H) , 7.54 (d, J=8.5Hz, 2H) , 7.53 ( , 2H) , 7.04 (t, J=8.8Hz, 2H) , 3.08 (s, 3H) , 2.79 (s, 3H) . F NMR (CDCI3) -112.61 (m) . Mass spectrum M+= 430. Example 40 4- (4-Bromophenyl ) -2- ( 2-chlorophenyl ) -5- [4- (methylsulfonyl) henyl] thiazole Step 1: Preparation of 2- ( -bromophenyl) - (4- methvlthiophenvDpropenoic acid: A mixture of acetic anhydride (100 mL) , 4- (methylthio)benzaldehyde (12.61 g, 82.8 mmol), 4- bromophenylacetic acid (17.79 g, 82.7 mmol), and triethylamine (8.48 g, 83.8 mmol) was heated to reflux for 4.25 hours. The reaction was cooled to 90°C, and water (100 mL) was added. A yellow solid separated from the solution and was isolated by filtration and air dried and recrystallized from a mixture of ethyl acetate and isooctane to afford the acid (12.83 g, 44%) : mp 187-190°C. 1H NMR (acetone d6) 300 MHz 7.83 (s, IH) , 7.57 (d, J=8.5Hz, lH) , 7.20 (d, J=8.5Hz, 2H) , 7.10 (d, J=8.lHz, 2H) , 7.08 (d, J=8.lHz, IH) , 2.46 (s, 3H) . Mass spectrum M++H=350. Step 2: Preparation of 1- (4-bromophenvl)2- (4- methvlthiophenvl) ethanone: A solution of 3- (4-methylthiophenyl) -2- (4- bromophenyDpropenoic acid from Step 1 (12.66 g, 36 mmol) and triethylamine (4.27 g, 42 mmol) was dissolved in 60 mL of anhydrous toluene, cooled to 0°C and treated with diphenylphosphoryl azide (10.04 g, 36 mmol) . The solution was maintained at 0°C for 0.5 hour and warmed to room temperature for 3.33 hours. The reaction was poured into water, extracted with ether, dried over magnesium sulfate, and concentrated in vacuo to remove the ether. The remaining toluene solution was heated to 100 °C for 1 hour. tert-Butyl alcohol (6.5 mL) was added to the reaction mixture. After an additional ten minutes, concentrated hydrochloric acid (4 mL) was cautiously added and the reaction maintained at 80°C for 72 hours. After cooling with an ice bath, a solid separated and was isolated by filtration, washed with water, and air dried to afford pure white ketone (8.41 g, 72%) : mp 158.5-163°C. 1H NMR (acetone d6) 300 MHz 8.00 (d, J=8.3Hz, 2H) , 7.71 (d, J=8.3Hz, 2H) , 7.24 (s, 4H) , 4.35 (s, 2H) , 2.47 (s, 3H) . Mass spectrum M++H= 321 and 323. Step 3: Preparation of 2-bromo-l- (4-bromophenvl) -2- (4- methvlthiophenvl) ethanone: A solution of 1- (4-bromophenyl) -2- (4- methylthiophenyl)ethanone from Step 2 (8.40 g, 26 mmol) in acetic acid (135 mL) and 33% HBr in acetic acid (1.5 mL) was treated with a 0.99 M solution of bromine in acetic acid (27 mL, 26.6 mmol) and stirred at room temperature for ten minutes. The solution was concentrated in vacuo and the residue taken up in dichloromethane, washed with IN NaHS03, 10% Na2C03 , dried over anhydrous MgSθ4, filtered and concentrated in vacuo to give a gray solid which was recrystallized from a mixture of dichloromethane and isooctane to provide the bromoketone (8.50 g, 81%) : mp 107-111°C. lH NMR (CDCI3) 300 MHz 7.83 (d, J=8.7Hz, 2H) , 7.58 (d, J=8.7Hz, 2H) , 7.41 (d, J=8.3Hz, 2H) , 7.22 (d, J=8.3Hz, 2H) , 6.27 (s, IH) , 2.47 (s, 3H) . Mass spectrum M++H=399, 401 and 403. Step 4: Preparation of 4- (4-bromopheny1) -2- (2- chlorophenvl)-5- (4-methvlthiophenvl) hiazole: A solution of 2-bromo-l- (4-bromophenyl) -2- (4- methylthiophenyl)ethanone from Step 3 (1.18 g, 2.9 mmol) and 4-chlorothiobenzamide (520 mg, 3.0 mmol) in 40 mL of acetonitrile was heated to reflux for 1.75 hours. The solution was cooled to room temperature, poured into 100 mL of methanol and chilled with an ice bath, whereupon white crystals of pure product formed which were isolated by filtration and air dried. The product was further purified by flash chromatography over silica gel eluting with 8% ether in hexane to afford pure thiazole (1.10 g, 79%) which was used directly in the next step: mp 133-135°C, 1H NMR (CDCI3) 300 MHz 8.35 (m, IH) , 7.52-7.21 (m, 11H) , 2.51 (s, 3H) . Mass spectrum M++H=474. Step 5: Preparation of 4- (4-bromopheny1) -2- (2- chloroohenv] )-5- ( -methylsulfonylphenyl) thiazol : A solution of 4- (4-bromophenyl) -2- (2- chlorophenyl) -5- (4-methylthiophenyl) thiazole from Step 4 (1.06 g, 2.2 mmol) in 15 mL of dichloromethane was treated with ffi-chloroperoxybenzoic acid (1.60 g, 4.6 mmol) at room temperature for 0.08 hour. The solution was diluted with additional dichloromethane, washed with 10% aq. NaHS03 , 10% Na2C03, dried over anhydrous MgS04, filtered and concentrated in vacuo to give a white solid that was purified by recrystallization from a mixture of dichloromethane and isooctane to give the product (850 mg, 75%): mp 168-184°C. 1H NMR (CDCI3) 300 MHz 8.38 (m, lH) , 7.92 (d, J=8.5Hz, 2H) , 7.60 (d, J=8.5Hz, 2H) , 7.54-7.38 (m, 7H) , 3.10 (s, 3H) . High resolution mass spectrum Calc'd. for C22Hl5BrClN02S: 502.9416. Found: 502.9436. Example 41 4- ( 4-Fluorophenyl ) -2- [ ( - methoxyphenoxy)methyl] -5- [4- (methylsulfonyl) phenyl] thiazole Step 1: Preparation of 4- (4-fluorophenvl) -5- (4- ιηethγlthJ0Phenyl)-2-( (4- methoxvphenoxv)methvl)thiazole: A solution of 1- (4-fluorophenyl) -2- (4- methylthiophenyl) -2-bromo-ethanone, (Example 1, Step 3) (2.30 g, 6.8 mmol) and 4-methoxyphenoxy thioacetamide (1.35 g, 6.8 mmol) in 20 mL of acetonitrile was heated to reflux for 1.1 hours. The solution was concentrated in vacuo and the residue dissolved in ethyl acetate. The ethyl acetate solution was washed with saturated aqueous NaHC03 , brine, dried over anhydrous MgSθ4, filtered and concentrated in vacuo to afford * a solid that was recrystallized from a mixture of ethyl acetate and isooctane to provide pure 4- (4-fluorophenyl) -5- (4- methylthiophenyl) -2- ( (4-methoxyphenoxy)methyl)thiazole (1.60 g; 54%) : mp 89-92°C, 1H NMR (CDCI3) 300 MHz 7.47 (dd, J= 3.2, 8.7Hz, 2H) , 7.23 (d, J= 8.5Hz, 2H) , 7.17 (d, J=8.5Hz, 2H) , 6.98 (m, 4H) , 6.86 (d, J=9.lHz, 2H) , 5.33 (s, 2H), 3.78 (s, 3H) , 2.49 (s, 3H) . 19F NMR (CDCI3) -114.07 (m) . Mass spectrum M+H+= 438. Step 2: Preparation of 4- (4-fluorophenvl) -5- (4- methvlsulfonvlphenvl) -2- ( (4- methoxvphenoxv)methvl)thiazole: A dichloromethane (20 mL) solution of 4- (4- fluorophenyl) -5- (4-methylthiophenyl) -2- ( (4- methoxyphenoxy)methyl) thiazole from Step 1 (1.45 g, 3.3 mmol) was treated with ffi-chloroperoxybenzoic acid (2.32 g, 6.7 mmol) and stirred at room temperature for 0.42 hour. The solution was washed with 10% aqueous NaHS03 , 10% Na2C03, dried over anhydrous MgS04, filtered and concentrated in vacuo to give a tan solid that was recrystallized from a mixture of dichloromethane and isooctane to afford 0.93 g (60%) of pure 4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) - 2- ( (4-methoxyphenoxy)methyl) thiazole as a light tan solid: mp 160-164°C. 1H NMR (CDCI3) 300 MHz 7.88 (d, J= 8.3Hz, 2H) , 7.71 (d, J= 8.3Hz, 2H) , 7.45 (dd, J=5.4, 8.7Hz, 2H) , 7.03 (d, J=8.7Hz, 5H) , 6.98 (d, J=9.lHz, 2H) , 8.68 (d, J=9.lHz, 2H) , 5.35 (s, 2H) , 3.77 (s, 3H) , 3.08 (s, 3H) . 1 F NMR (CDCI3) 112.80 (m) . High resolution mass spectrum Calc'd. for C24H20FNO4S2: 469.0818. Found: 469.0854. Example 42 2-Ethyl-4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl) thiazole Step 1: Preparation of 2-ethvl-4- (4-fluorophenyl) -5- (4-methvlthiophenvl) thiazole: To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylthiophenyl) ethanone (Example 1, Step 3) (0.250 g, 0.737 mmol) in ethanol (9 mL) was added thiopropionamide (0.066 g, 0.737 mmol) and the mixture was heated to reflux overnight. The reaction was cooled to room temperature, diluted with ethyl acetate (50 mL) , washed with NaHCθ 3 (10% solution) , brine, dried over Na 2 Sθ4, filtered and concentrated in vacuo . The crude thiazole was recrystallized from methylene chloride and isooctane yielding 2-ethyl-4- (4- fluorophenyl) -5- (4-methylthiophenyl) thiazole (0.14 g, 57 %) as pale yellow crystals: mp 73-74°C; 1 H NMR (CDCI 3 ) 300 MHz 7.55 (m, 2H) , 7.26 (d, J = 7.85, 2H) , 7.21 (d, J = 7.85, 2H) , 7.03 (t, J = 7.85, 2 H) , 3.12 (q, J = 7.50 Hz, 2H) , 2.54 (s, 3H) , 1.47 (t, J = 7.50 Hz, 3 H) ; MS (FAB) m/z 330.08 (MH+) , HRMS (El) Δ = -4.2 mmu. Step 2: Preparation of 2-ethvl-4- (4-fluorophenvl) -5- (4-methvlsulfonvlphenvl)thiazole: To a solution of 2-ethyl-4- (4-fluorophenyl) -5- (4- methylthiophenyl)thiazole from step 1 (0.105 g, 0.32 mmol) in methylene chloride (5 mL) was added at room temperature MCPBA (0.21 g of 67% peroxide content MCPBA, 0.80 mmol) and the reaction was warmed to room temperature and stand for 2 hours. The crude reaction mixture was diluted with methylene chloride (50 mL) and the resulting solution was washed with NaHS03 solution (0.1 M) , NaHCθ 3 saturated solution, and brine, dried over Na 2 S0 4 , filtered and concentrated in vacuo yielding a solid. This solid was purified by flash chromatography (hexane:ethyl acetate 1:1 with 2% acetic acid) yielding 4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl)-2-ethylthiazole (0.080g, 69%) as a white foam: mp 156-157°C; 1 H NMR (CDCI 3 ) 300 MHz 7.86 (d, J = 8.48 Hz, 2H) , 7.45 (m, 4 H) , 7.00 (t, 8.48 Hz, 2H) , 3.13-3.05 (m, 5H) , 1.44 (t, J = 7.37 Hz, 3H) ; MS (FAB) m/z 362.07 (MH+), HRMS (MH+) Δ = -2.6 mmu. Example 43 4- ( 4 -Fluorophenyl) -5- ( -methylsulfonylphenyl ) - 2- ( 3-phenylpropyl ) thiazole Step 1: Preparation of 4-phenvlthiobutyramide: To a solution of 4-phenylbutyramide (0.373 g, 2.28 mmol) in toluene (15 mL) was added Lawesson's reagent (0.461 g, 1.14 mmol) . The reaction was heated at reflux overnight, cooled to room temperature and concentrated yielding an orange oil. Flash chromatography of this oil (1:1 hexane:methylene chloride with 1% acetic acid) yielded 4- phenylthiobutyramide (0.184 g) as a white solid: 1 H NMR (DMSO d 6 ) 400 MHz 9.33 (s, 1 H) , 9.13 ( s, 1 H) , 7.29-7.23 (m, 2 H) , 7.20-7.15 (m, 3 H) , 2.56 (t, J = 7.58 Hz, 2 H) , 2.50-2.42 (m, 2 H) , 2.00-1.85 (m, 2 H) . Step 2: Preparation of 4- (4-fluorophenvl) -5- (4- methvlthiophenvl) -2- (3-phenvlpropvl)thiazole: To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylthiophenyl) ethanone (Example 1, step 3) (0.100 g, 0.295 mmol) in ethanol (3 mL) was added 4- phenylthiobutyramide from step 1 (0.055 g, 0.310 mmol) and the mixture was heated to reflux overnight. The reaction was cooled to room temperature, diluted with ethyl acetate (50 mL) , washed with Na 2 Cθ 3 (10% solution) , brine, dried over Na 2 Sθ 4 , filtered and concentrated in vacuo . The crude thiazole was purified by flash chromatography (9:1, hexane:ethyl acetate) yielding 4- (4-fluorophenyl) -5- (4-methylthiophenyl) -2- (3-phenylpropyl) thiazole (0.118 g, 95%) as crystalline solid: mp 62-63°C; 1 H NMR (CDC1 3 ) 300 MHz 7.49 (d of d, J = 5.52 and 8.85, 2H) , 7.33 - 7.14 (m, 9H) , 6.98 (t, J = 8.85, 2H) , 3.05 (t, J = 7.74, 2 H) , 2.82 (t, J = 7.74 Hz, 2H) , 2.49 (ε, 3H) , 2.18 (m, 2 H) ; MS (FAB) m/z 420 (MH+) . Step 3: Preparation of 4- (4-fluorophenvl) -5- (4- methvlsulfonvlphenvl) -2- (3-phenvlpropvl)thiazole: To a solution of 4- (4-fluorophenyl) -5- (4- methylthiophenyl) -2- (3-phenylpropyl) thiazole from step 2 (0.11 g, 0.26 mmol) in methylene chloride (3 mL) was added at room temperature MCPBA (0.20 g of 67% peroxide content MCPBA, 0.79 mmol) and the reaction was warmed to room temperature and let stand for 2 days. The crude reaction mixture was diluted with methylene chloride (50 mL) and the resulting solution was washed with NaHSθ 3 solution (0.1 M) , NaHCθ 3 saturated solution, and brine, dried over Na 2 ≤θ 4 , filtered and concentrated in vacuo . This product was purified by flash chromatography (1:1 hexane:ethyl acetate with 2% acetic acid) yielding 4- (4- fluorophenyl) -5- (4-methylsulfonylphenyl) -2- (3- phenylpropyl) thiazole ( 0.040 g, 34 %) as an oily off- white foam: 2 H NMR (CDCI 3 ) 300 MHz 7.87 (d, J = 8.31 Hz, ' 2H) , 7.52 - 7.42 (m, 2 H) , 7.38 (d, 8.68 Hz, 2H) , 7.76 - 7.18 (m, 5 H) , 7.11 (t, J = 8.68 Hz, 2 H) , 3.15 (t, J = 7.55 Hz, 2H) , 3.05 (s, 3 H) , 2.83 (t, J = 7.55 Hz, 2 H) , 2.19 (m 2 H) ; MS (El) m/z 452.12 (MH+), HRMS (MH+) Δ = -3.1 mmu. Example 44 4 - (4-Fluorophenyl) -5- ( 4-methylsulfonylphenyl ) - 2- (2-phenylethyl ) thiazole Step 1; Preparation of 3-phenγlthioprppionamide; To a solution of 3-phenylpropionamide (1.653 g, 6.827 mmol) in toluene (20 mL) was added Lawesson's reagent (0.716 g, 1.77 mmol) . The reaction was heated at reflux overnight, cooled to room temperature and concentrated, yielding an orange oil. Flash chromatography of this oil (1:1 hexane:methylene chloride with 1% acetic acid) yielded 3- phenylthiopropionamide (0.070 g) as a white solid: mp 82-83°C; l H NMR (DMSO dβ) 300 MHz 9.35 (br s, 1 H) , 9.15 (br s, 1 H) , 7.34-7.10 (m, 2 H) , 2.95 (t, J = 8.48 Hz, 2 H) , 2.72 (t, J = 8.48 Hz, 2 H) . Step 2: Preparation of 4- (4-fluorophenvl) -5- (4- methvlthiophenvl) -2- (2-phenvlethvl) thiazole To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylthiophenyl) ethanone (Example 1, Step 3) (0.115 g, 0.340 mmol) in ethanol (4 mL) was added 3- phenylthiopropionamide from Step 1 (0.059 g, 0.357 mmol) and the mixture was heated to reflux overnight. The reaction was cooled to room temperature, diluted with ethyl acetate (50 mL) , washed with Na 2 C0 3 (10 % solution) , brine, dried over Na 2 Sθ 4 , filtered and concentrated in vacuo yielding 4- (4-fluorophenyl) -5- (4-methylthiophenyl) -2- (2-phenylethyl) thiazole (0.090 g, 65%) as oily crystals: mp 97-99°C; 1 H NMR (CDCI 3 ) 300 MHz 7.50 (d of d, J = 5.38 and 8.80, 2 H) , 7.35 - 7.15 (m, 9H) , 6.99 (t, J = 8.80, 2H) , 3.35 (t, J = 8.80, 2 H) , 3.19 (t, J = 8.56 Hz, 2H) , 2.49 (s, 3H) ; MS (El) m/z 405.10 (MH+) , HRMS (M+) Δ = 0.0 mmu. Step 3: Preparation of 4- (4-fluorophenvl) -5- (4- methvlsulfonvlphenvl) -2- (2-phenvlethvl) thiazole To a solution of 4- (4-fluorophenyl) -5- (4- methylthiophenyl) -2- (2-phenylethyl) thiazole from Step 2 (0.080 g, 0.21 mmol) in methylene chloride (3 mL) was added at room temperature MCPBA (0.110 g of 67% peroxide content MCPBA, 0.42 mmol) and the reaction was warmed to room temperature and let stand for 2 days. The crude reaction mixture was diluted with methylene chloride (50 mL) and the resulting solution was washed with NaHSθ 3 solution (0.1 M) , NaHC03 saturated solution, and brine, dried over Na 2 Sθ 4 , filtered and concentrated in vacuo . This product was recrystallized from methylene chloride and isooctane yielding 4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl) -2- (2-phenylethyl) thiazole (O.lllg, 100%) as a fluffy white solid: mp 153-154°C; 1 H NMR (CDCI 3 ) 400 MHz 7.86 (d, J = 8.30 Hz, 2H) , 7.48 - 7.42 (m, 4 H) , 7.37 - 7.22 (m, 5 H) , 7.02 (t, J = 8.79 Hz, 2 H) , , 5 H) , 3.39 (t, J = 6.84 Hz, 2H) , 3.19 (t, J = 7.32, 2 H) , 3.08 (s, 3 H) ; MS (CD m/z 438 (MH+), HRMS (MH+) Δ = 2.4 mmu. Example 45 4- (4-Fluorophenyl) -5- (4-methylsulfonylphenyl ) - 2-phenylthiazole To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylsulfonylphenyl) ethanone (Example 26, Step 2) (0.468 g, 1.26 mmol) in acetonitrile (10 mL) was added thiobenzamide (0.164 g, 1.20 mmol) and the solution was heated to reflux (19 hours) . The reaction was cooled to room temperature. The resulting suspension was concentrated in vacuo, suspended in methylene chloride (100 mL) and washed with NaHC0 3 saturated solution (3 x 10 mL) , dried over sodium sulfate, filtered and concentrated yielding 4- (4-fluorophenyl) - 5- (4-methylsulfonylphenyl) -2-phenylthiazole (0.085 g, 16%) as a fine white powder: mp 188-189°C, 1 H NMR (CDCI 3 ) 300 MHz 8.01 (m, 2H) , 7.90 (d, J = 8.48 Hz, 2 H) , 7.62-7.55 (m, 4 H) , 7.55-7.44 (m, 3 H) , 7.04 (t, J = 8.85 Hz, 2 H) , 3.09 (s, 3H) ; MS (El-thermospray) m/z 410 (MH+) . HRMS (El) Δ = -2.0 mmu. Example 46 4- (4-Fluorophenyl) -2-n-hexylamino-5- (4- methylsulfonylphenyl)thiazole To a solution of 2-bromo-l- (4-fluorophenyl)-2- (4- methylsulfonylphenyl)ethanone (Example 26, Step 2) (0.503 g, 1.35 mmol) in ethanol (10 mL) was added N- hexylthiourea (0.239, 1.49 mmol). The solution was heated to reflux for 14 hours and was cooled to room temperature. The resulting suspension was concentrated in vacuo, suspended in methylene chloride (100 mL) and washed with NaHC0 3 saturated solution (3 x 10 mL) , dried over sodium sulfate, filtered and concentrated yielding 4- (4-fluorophenyl) -2-n-hexylamino-5- (4- methylsulfonylphenyl)thiazole (0.420 g, 72%) as a white powder: mp 161-162°C, 1 H NMR (DMSO d& ) 400 MHz 7.95 (t, J = 5.38 Hz, 1 H) , 7.77 (d, J = 8.79 Hz, 2 H) , 7.44-7.36 (m, 4 H) , 7.15 (t, J = 9.28, 2 H) , 3.24 ( q , J = 5.86, 2H) , 3.18 (s, 3 H) , 1.61-1.52 (m, 2 H) , 1.38-1.20 (m, 6 H) , 0.85 (t, J = 6.84 Hz, 3 H) ; MS (FAB) m/z 433 (MH+) . HRMS Δ = -0.9 mmu. Example 47 2-Butylamino-4- ( -fluorophenyl ) -5- ( - methylsulf onylphenyl ) thiazole To a solution of 2-bromo-l- (4-f luorophenyl) -2- (4- methylsulfonylphenyl) ethanone (Example 26, Step 2) (0.384 g, 1.03 mmol) in ethanol (15 mL) was added N- butylthiourea (0.144 g, 1.09 mmol). The solution was heated to reflux for 14 hours and cooled to room temperature. The resulting suspension was concentrated in vacuo, suspended in methylene chloride (100 mL) and washed with NaHCθ 3 saturated solution (3 x 10 mL) , dried over sodium sulfate, filtered and concentrated yielding 2-butylamino-4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl)thiazole (0.319 g, 77%) as an off-white fluffy solid: mp 134-135°C, 1 H NMR (DMSO dβ) 7.94 (t, J = 5.37 Hz, 1 H) , 7.78 (d, J = 8.79, 2 H) , 7.45-7.36 (m, 4 H) , 7.15 (t, J = 8.79 Hz, 2H) , 3.25 (q, J = 5.37 Hz, 2 H) , 3.18 (s, 3 H) , 1.58-1.50 (m, 2 H) , 1.41-1.32 (m, 2H) , 0.90 (t, J = 7.33 Hz, 3 H) ; MS (El) m/z 404 (M+) . HRMS Δ = 1.1 mmu. Example 48 4- ( 4-Fluorophenyl) -5- ( 4-methylsulfonylphenyl ) - 2-methylaminothiazole To a solution of 2-bromo-1- (4-fluorophenyl) -2- (4- methylsulfonylphenyl)ethanone (Example 26, Step 2) (0.355 g, 0.959 mmol) in ethanol (10 mL) was added N- methylthiourea (0.086 g, 0.959 mmol) . The solution was heated to reflux for 14 hours and cooled to room temperature. The resulting suspension was concentrated in vacuo, suspended in ethyl acetate (100 mL) and washed with NaHC0 3 saturated solution (3 x 10 mL) , dried over sodium sulfate and filtered. Isooctane was added to the filtrate until the solution became cloudy yielding a pale yellow fluffy solid which was collected by vacuum filtration. This solid was dissolved in methylene chloride and washed with sodium carbonate solution (10% solution) , dried over sodium sulfate, and concentrated yielding a solid. This solid was recrystallized from methylene chloride-isooctane yielding 4- (4-fluorophenyl) -2-methylamino-5- (4- methylsulfonylphenyl) thiazole (0.135 g, 39 %) as a pale yellow powder: mp 243-244°C; λ U NMR 400 MHz 7.90 (q, J = 4.76 Hz, 1 H) , 7.81 (d, J = 8.50 Hz, 2 H) , 7.49-7.43 (m, 2 H) , 7.41 (t, J = 8.70 Hz, 2 H) , 7.19 (t, J = 8.95 Hz, 2 H) , 3.22 ( s, 3 H) , 2.90 (d, J = 4.80 Hz, 3 H) ; MS (FAB) m/z 363 (M+H) . HRMS Δ = -0.2 mmu. Example 49 4- ( 4-Fluorophenyl ) -5- (4-methylsulfonylphenyl ) - 2- (4-methoxyphenyl) thiazole To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylsulfonylphenyl)ethanone (Example 26, Step 2) (0.500 g, 1.35 mmol) in isopropanol (10 mL) was added p-methoxythiobenzamide (0.230 g, 1.35 mmol). The solution was heated to reflux for 30 hours and cooled to room temperature. The resulting suspension was concentrated in vacuo, suspended in methylene chloride (100 mL) and washed with NaHC0 3 saturated solution (3 x 10 mL) , dried over sodium sulfate, filtered and concentrated yielding 4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl) -2- (4-methoxyphenyl) thiazole (0.360 g, 61%) as a crystalline solid: mp 187-189°C, X H NMR (CDCI 3 ) 300 MHz 7.99 (d, 8.82 Hz, 2 H) , 7.93 (d, J = 8.50 Hz, 2 H) , 7.63-7.53 (m, 4 H) , 7.09 (t, J = 8.63 Hz, 2 H) , 7.03 (d, J = 8.82 Hz, 2 H) , 3.92 ( ε, 3 H) , 3.13 (s, 3 H); MS m/z 440 (M+H) . HRMS Δ = 2.0 mmu. Example 50 2-Ethylamino-4- (4-fluorophenyl) -5- ( 4' methylsulfonylphenyl) -thiazole To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylεulfonylphenyl)ethanone (Example 26, Step 2) (0.405 g, 1.09 mmol) in ethanol (10 mL) was added N- ethylthiourea (0.114 g, 1.09 mmol) and the solution was heated to reflux for 14 hours. The reaction was cooled to room temperature and the resulting suspension was concentrated in vacuo, suspended in methylene chloride (100 mL) and washed with NaHCθ 3 saturated solution (3 x 10 mL) , εodium carbonate εolution (10%, 3 x 20 mL) , dried over sodium sulfate, filtered and concentrated. The crude product was recrystallized from methylene chloride and isooctane yielding 2-ethylamino-4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl)thiazole (0.218 g, 53%) as a white powdery crystals: mp 218-219°C, X H NMR (DMSO dβ) 400 MHz 7.94 (t, 5.38 Hz, 1 H) , 7.78 (d, J = 8.56 Hz, 2 H) , 7.45-7.40 (m, ' 2 H) , 7.37 (d, J = 8.56 Hz, 2 H) , 7.15 (t, J = 9.05 Hz, 2 H) , 3.31 ( q, J = 7.10 Hz, 2 H) , 3.18 (s, 3 H) , 1.18 (t, J = 7.10 Hz, 3 H) ; MS m/z 377 (M+H) . HRMS Δ = 0.5 mmu. Example 51 2-tert-Butylamino-4- ( 4-fluorophenyl ) -5- (4 methylsulfonylphenyl) thiazole To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylεulfonylphenyl) ethanone (Example 26, Step 2) (0.406 g, 1.09 mmol) in ethanol (11 mL) was added N- ( tert-butyl) thiourea (0.144 g, 1.09 mmol) and the solution was heated to reflux (14 hourε) . The reaction was cooled to room temperature. The resulting suspension was concentrated in vacuo, suspended in methylene chloride (100 mL) and washed with NaHCθ 3 saturated solution (3 x 10 mL) , sodium carbonate solution (10%, 3 x 20 mL) , dried over sodium sulfate, filtered and concentrated. The crude product was recrystallized from methylene chloride and isooctane yielding 4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl) -2-tert-butylaminothiazole (0.226 g, 51%) as a yellow crystalline plates: mp 250-253°C; X H NMR (DMSO de ) 400 MHz 7.78 (d, J = 8.32 Hz, 2 H) , 7.70 (ε, 1 H), 7.46-7.35 (m, 4 H) , 7.15 (t, J = 9.05 Hz, 2 H) , 3.19 (s, 3 H) , 1.40 (ε, 9 H) ; MS m/z 405 (M+H) . HRMS Δ = 4.78 mmu. Example 52 2- ( 3 , 5-Dichlorophenylamino) -4- (4-fluorophenyl ) - 5- ( 4-methylsulfonylphenyl ) thiazole To a solution of 2-bromo-1- (4-fluorophenyl) -2- (4- methylsulfonylphenyl)ethanone (Example 26, Step 2) (0.312, 0.841 mmol) in ethanol (10 mL) was added N- (3, 5-dichlorophenyl)thiourea (0.195 g, 0.882 mmol). The solution was heated to reflux (14 hours) and cooled to room temperature. The resulting suspension was concentrated in vacuo, εuεpended in ethyl acetate (100 mL) and washed with sodium carbonate solution (10%, 3 x 20 mL) , brine (20 mL) , dried over sodium sulfate, filtered and concentrated, yielding a powdery solid. This solid was dissolved in ethyl acetate/methylene chloride. Addition of isooctane resulted in the precipitation of 2- (3,5- dichlorophenylamino) -4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl)thiazole (0.261 g, 63%) as a pale yellow powder: mp 287-288°C; 1 H NMR (DMSO de ) 400 MHz 10.84 (s, 1 H) , 7.86 (d, J = 8.79 Hz, 2 H) , 7.73 (ε, 2 H) , 7.54-7.45 (m, 4 H) , 7.22 (t, J = 8.79 Hz, 2 H) , 7.15 (s, 1 H) , 3.22 (s, 3 H) ; MS m/z 492 (M+) . HRMS Δ = 4.8 mmu. Example 53 2- ( 4-Cyanophenylamino) -4- (4-fluorophenyl ) -5- (4- methylsulfonylphenyl) -thiazole To a solution of 2-bromo-1- (4-fluorophenyl) -2- (4- methylεulfonylphenyl)ethanone (Example 26, Step 2) (0.413, 1.11 mmol) in ethanol (10 mL) was added N-(4- cyanophenyl) thiourea (0.207 g, 1.17 mmol) . The solution was heated to reflux (24 hours) and cooled to room temperature. The resulting suspension was concentrated in vacuo, suεpended in methylene chloride (100 mL) and washed with sodium carbonate solution (10%, 3 x 20 mL) , brine (20 mL) , dried over sodium sulfate, filtered and concentrated yielding a solid. This solid was purified by flash chromatography (1:1, hexane:ethyl acetate with 1% acetic acid) . The resulting product was recrystallized from methylene chloride and isooctane yielding 2- (4- cyanophenylamino) -4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl) thiazole (0.266 g, 53%) as a pale yellow solid: mp 273-274°C; X H NMR (DMSO de ) 400 MHz 10.98 (s, 1 H) , 7.86 (d, J = 8.32 Hz, 2 H) , 7.83 (d, J = 9.05 Hz, 2 H) , 7.76 (d, J = 8.80 Hz, 2 H) , 7.55-7.47 (m, 4 H) , 7.21 (t, J = 8.80 Hz, 2 H) , 3.22 (s, 3 H) ; MS m/z 450 (M+H) . HRMS Δ = 2.6 mmu. Example 54 Ethyl- [3- [4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl) -2- thiazolyl] amino] benzoate To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylsulfonylphenyl)ethanone (Example 26, Step 2) (0.444, 1.20 mmol) in ethanol (10 mL) was added N-(3- ethoxycarbonylphenyl)thiourea (0.282 g, 1.26 mmol) . The solution was heated to reflux (24 hours) and was cooled to room temperature. The resulting suεpension was concentrated in vacuo, suspended in methylene chloride (100 mL) and washed with sodium carbonate solution (10%, 3 x 20 mL) , brine (20 mL) , dried over sodium sulfate, filtered and concentrated yielding a solid. The resulting product was recrystallized from methylene chloride and isooctane yielding ethyl [3-[4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2- thiazolyl] amino]benzoate (0.393 g, 66%) as a pale yellow fluffy solid: mp 208-209°C; ^-H NMR (DMSO de ) 400 MHz 10.68 (s, 1 H) , 8.45 (s, 1 H) , 7.91-7.84 (m, 3 H) , 7.58-7.44 (m, 6 H) , 7.19 (t, J = 8.79 Hz, 2 H) , 4.30 ( q, J = 6.84 Hz. 2 H) , 3.21 (ε, 3 H) , MS m/z 496 (M+) . HRMS Δ = 0.03 mmu. Example 55 OEt Ethyl [4- [4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl ) -2- thiazolyl] amino]benzoate To a solution of 2-bromo-l- (4-fluorophenyl) -2- (4- methylsulfonylphenyl) ethanone (Example 26, Step 2) (0.361, 0.972 mmol) in ethanol (10 mL) was added N-(4- ethoxycarbonylphenyl) thiourea (0.229 g, 1.02 mmol) . The solution was heated to reflux (24 hours) and was cooled to room temperature. The resulting suεpension was concentrated in vacuo, suεpended in methylene chloride (100 mL) and washed with sodium carbonate solution (10%, 3 x 20 mL) , brine (20 mL) , dried over sodium sulfate, filtered and concentrated yielding a solid. The resulting product was recrystallized from methylene chloride and isooctane yielding ethyl [4- [4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2- thiazolyl] amino]benzoate (0.277 g, 57%) as a fine, pale yellow crystals: mp 207-208°C; *H NMR (DMSO-d δ ) 400 MHz 10.87 (s, 1 H) , 7.93 (d, J = 8.79 Hz, 2 H) , 7.87 (d, J = 8.30 Hz, 2 H) , 7.78 (d, J = 8.79, 2 H) , 7.57-7.49 (m, 4 H) , 7.20 (t, J = 9.28 Hz, 2 H) , 4.26 ( q, J = 7.32 Hz, 2 H) , 3.21 (s, 3 H) , 1.29 (t, J = 7.32 Hz, 3 H) . MS m/z 496 (M+) . HRMS Δ = 0.2 mmu. Example 56 5- (4-Fluorophenyl) -4- ( -methylsulfonylphenyl) - 2-trifluoromethylthiazole: Step 1: Preparation of 5- (4-fluorophenvl) -4- (4- methvlthiophenvl) -2-trifluoromethylthiazole: To a εolution of trifluoroacetamide (13.7 g, 121.2 mmol) in toluene (30 mL) was added solid P 4 S 1 0 (5.4 g, 12.1 mmol) and the mixture was heated to reflux for 60 hours. The resulting orange suspension was cooled to room temperature and the solid was pulverized to form a fine suspension. One fourth of this toluene suεpenεion (7.5 mL, c_a_. 30 mmol of theory) waε transferred and 2-bromo-2- (4- fluorophenyl) -1- (4-methylthiophenyl)ethanone (1.24 g, 3.66 mmol) (Example 20, Step 2) was added in one portion. This suspenεion waε heated to reflux for 1.5 hourε, cooled to 50°C, and 1.0 N HCI εolution (1 mL) was added carefully and heating at reflux continued for 1 hour more. This reaction was cooled to room temperature and let stand overnight. To this εolution waε added 2 N NaOH εolution until the exotherm εubεided, and the reaction waε stirred for 1 hour longer. The reεulting black εuεpension was diluted with methylene chloride and washed with NaHCθ 3 saturated εolution, dried over Na 2 Sθ 4 , filtered and concentrated in vacuo yielding a brown semi-solid. Flash chromatography (9:1 hexane:methylene chloride) yielded 5- (4-fluorophenyl)-4- (4-methylthiophenyl) -2- trifluoromethylthiazole (0.28 g, 23%) as yellow oil which slowly solidified mp: 59-60°C; λ U NMR (CDCI 3 ) 300 MHz 7.43 (d, J = 8.48, 2 H) , 7.40-7.32 (m, 2 H) , 7.17 (d, J = 8.48 Hz, 2 H) , 7.08 (t, J = 8.48, 2 H)2.46 (s, 3 H) ; MS (El) m/z 369 (M+H) . HRMS Δ = -3.17 mmu. Step 2: Preparation of 5- (4-fluorophenvl) -4- (4- methvlsulfonvlphenvl) -2-trifluoromethylthiazole: To a solution of 2-trifluoromethyl-5- (4- fluorophenyl) -4- (4-methylthiophenyl)thiazole from Step 1 (0.25 g, 0.74 mmol) in methylene chloride (10 mL) at 0°C was added MCPBA (0.50 g of 67% peroxide content reagent, 1.9 mmol) in three portionε over 2 hourε. After 3 hourε total reaction time, the reaction waε diluted with methylene chloride ( 150 mL) and thiε solution was washed with NaHS0 3 solution (0.1 M) /NaHCθ 3 εaturated εolution (1:1 ratio, 3 x 50 mL) , dried over MgS0 4 , filtered and concentrated in vacuo . The resulting solid was recrystallized from methylene chloride and isooctane yielding 5- (4-fluorophenyl) -4- (4-methylsulfonylphenyl) -2-trifluoromethylthiazole (0.19 g, 70%) as opaque white crystalε: mp 150-151°C; ! H NMR (CDCI 3 ) 300 MHz 7.89 (d, J = 8.48, 2 H) , 7.71 (d, J = 8.85, 2 H) , 7.40-7.30 ( m, 2 H) , 7.13 (t, J = 8.48 Hz, 2 H) , 3.06 (ε, 3 H) ; 19F NMR (CDC13) 300 MHz -61.53, -109.98; MS (El) m/z 402 (MH+) . HRMS Δ = -1.161 mmu. Example 57 4- ( 4-Fluorophenyl ) ) -5- ( 4-methylsulfonylphenyl) - 2- (2 , 3 , , 5, 6-pentafluorophenyl) thiazole Step 1: Preparation of pentafluorothiobenzamid : To a solution of pentafluorobenzamide (5.00 g, 23.69 mmol) in toluene (60 mL) was added Lawesson'ε reagent (5.70 g, 14.20 mmol) . The reaction waε heated at reflux overnight, cooled to room temperature, and isooctane (200 mL) was added causing a precipitate to form. The suspenεion was filtered and the filtrate was concentrated yielding an orange oil which solidified. Flash chromatography of this oil (1:1 hexane:methylene chloride with 2% acetic acid) yielded crude pentafluorothiobenzamide as a white εolid (mp 92-93°C) which was used without any further purification. Step 2: Preparation of 2-pentafluorophenvl-4- (4- fluorophenvl)-5- (4-methvlthiophenvl) thiazole: To a solution of 2-bromo-1- (4-fluorophenyl).-2- (4- methylthiophenyl)ethanone (Example 1, Step 3) (3.13 g, 9.22 mmol) in acetonitrile (90 mL) was added pentafluorothiobenzamide from Step 1 (2.2 g, 9.69 mmol) and the mixture waε heated to reflux for 16 hourε. The reεulting burgundy colored reaction εolution waε poured into hot methanol (400 mL) and the resulting solution was cooled to room temperature yielding a crystalline product. The crystalε were collected by vacuum filtration, redissolved in hot acetonitrile and methanol, Darco® decolorizing carbon was added, and the mixture was heated on a εtea bath to reflux for two minuteε. The resulting black suεpension was filtered. The filtrate was diluted with methanol to enhance recrystallization " yielding 2- pentafluorophenyl-4- (4-fluorophenyl) -5- (4- methylthiophenyl)thiazole as papery pale gray crystals (0.59 g, 14 %) : mp 131-132°C; X H NMR (CDC1 3 ) 300 MHz 7.60-7.50 (m, 2 H) , 7.31 (d, J = 8.11 Hz, 2 H) , 7.23 (d, J = 8.48 Hz, 2 H) , 7.02 (t, J = 8.48 Hz, 2 H) , 2.52 ( s, 3 H) ; MS (El) m/z 468 (M+H) . HRMS Δ = 1.66 mmu. Step 3: Preparation of 2-pentafluorophenyl-4- (4- fluorophenvl)-5- (4-methvlsulfonvlphenvl) thiazole: To a solution of 2-pentafluorophenyl-4- (4- fluorophenyl) -5- (4-methylthiophenyl) thiazole from step 2 (0.55 g, 1.18 mmol) in methylene chloride (15 mL) at 0°C was added MCPBA (0.51 g of 67% peroxide reagent, 2.94 mmol) and the solution was warmed to room temperature and let stand overnight . The reaction mixture was diluted with methylene chloride (100 mL) , washed with NaHSθ 3 solution (0.1 M) , NaHC0 3 saturated solution, dried over Na 2 Sθ 4 , filtered and concentrated in vacuo . The product was recrystallized from methylene chloride and isooctane yielding 2- pentafluorophenyl-4- (4-fluorophenyl) -5- (4- methylεulfonylphenyl) thiazole (0.48 g, 93%): mp 173- 174°C; 1 H NMR (CDC1 3 ) 300 MHz 7.95 (d, J = 8.48 Hz, 2 H) , 7.61 (d, J = 8.48, 2 H) , 7.52 (d of d, J = 5.16 and 8.48 Hz, 2 H) , 7.05 (t, J = 8.48 Hz, 2 H) , 3.11 (s, 3 H) ; 19 F NMR (CDCI 3 ) 300 MHz -111.9, -138.8, -150.5, -160.7; MS (El) m/z 499 (M+H) . HRMS Δ = 5.146 mmu . Example 58 [4- ( 4-Fluorophenyl) -5- ( 4- methylsulfonylphenyl ) -2-thiazolyl] acetic acid Step 1: Preparation of T4- (4-fluorophenvl ) -5- (4- methvlthiophenvl)-2-thiazolvl1acetic acid. To a stirred solution of 4- [4-fluorophenyl] -2- methyl-5- [ -methylthiophenyl]thiazole (Example 20, Step 3) (0.993 g, 3.15 mmol) in dry tetrahydrofuran (THF) (10 mL) under nitrogen in a dry ice- iεopropanol bath was added n-butyllithium (1.4 mL of 2.5 M in hexanes, 3.46 mmol) via syringe. The reaction became an almost opaque dark red color. After 10 minutes, the reaction was poured into a εlurry of dry-ice/THF under nitrogen atmoεphere. The exceεε CO 2 waε allowed to εublime and the reεulting yellow solution was concentrated in vacuo yielding a yellow semiεolid. Thiε εemiεolid was dissolved in H 2 O (80 mL) , washed with hexane and the layers separated. The aqueous phase was poured into 0.05 M HCI solution to give an orange solid. Recrystallization from ethanol/dichloromethane/isooctane yielded [4- (4- fluorophenyl) -5- (4-methylthiophenyl) -2- thiazolyl]acetic acid aε a solid (0.294 g, 26%) : mp 134 °C (dec) . ^-H NMR (CDCI 3 ) 300 MHz 7.50-7.42 (m, 2 H) , 7.22 (d, J = 8.1 Hz, 2 H) , 7.17 (d, J = 8.1 Hz, 2 H) , 6.98 (t, J = 8.7 Hz, 2 H) , 4.09 (s, 2 H) , 2.49 (ε, 2H) . LRMS: M+H obε. 360. HRMS: M+H Calc'd m/z 360.0528, obε m/z 360.0521. Anal. Calc'd for CI8H14FNO2S2 : C 60.16; H, 3.93, N, 3.90. Found: C, 59.93; H, 3.95; N, 3.88. Step 2: Preparation of f - (4- luorophenv ) -5- (4- methvlsulfonvlphenvl) -2-thiazolvllacet3 r. ari : To a solution of [4- (4-fluorophenyl) -5- (4- methylthiophenyl) -2-thiazolyl]acetic acid (Step 2) in ethanol (6 mL) and THF (3 mL) was added a solution of Oxone® (0.575 g, 1.869 mmol) in H 2 O (1.5 mL) and reacted for 2 hourε. The mixture was diluted with H 2 O (100 mL) , producing a fine yellow suspenεion which waε collected by vacuum filtration yielding [4- (4-fluorophenyl) -5- (4- methylεulfonylphenyl) -2-thiazolyl]acetic acid as a yellow powder (0.199 g, 82%) : mp 149-151 °C. 1 H NMR (CDCI 3 ) 300 MHz 7.85 (d, J = 8.66 Hz, 2 H) , 7.49 (d, J = 8.66 Hz, 2 H) , 7.47-7.36 (m, 2 H) , 6.98 (t, J = 8.70 Hz, 2 H) , 4.08 (ε, 2 h) , 3.06 (ε, 3 H) . LRMS: M+H obε m/z 392; HRMS: M+H Calc'd m/z 392.0427; obε. M+H m/z 392.0419. Anal. Calc'd for C18H14FNO4S2: C, 55.24; H, 3.61, N, 3.58. Found: C, 55.24; H, 3.70; N, 3.62. Example 59 4- [5- ( 4 -Chlorophenyl) -2 -methyl - thiazolyl] benzenesulfonamide Step 1: Preparation of 2- (4 -chlorophenyl) -1- phenvlethanone To a εolution of p-chlorophenylacetic acid (14.87 g, 87.16 mmol) in dichloromethane (300 mL) waε added dimethyl formamide (DMF) (0.5 mL) followed by careful dropwiεe addition of oxalyl chloride (8.0 mL, 11.61 g, 91.52 mmol) to maintain a moderate rate of gaε evolution. The reaction waε stirred for 2 hours, concentrated in vacuo, diluted with benzene (150 mL) , and AICI 3 waε added portionwiεe. The reaction was heated to reflux overnight. The reaction was cooled to room temperature, was diluted with dichloromethane (150 mL) and poured over ice with stirring. The layers were separated and the dichloromethane phase was filtered, washed with water, NaHCθ 3 saturated solution, brine, dried over MgS0 4 , filtered and concentrated in vacuo yielding the ketone as off white plates (16.72 g, 83%) : mp 132-133 °C. ^-H NMR (CDCI 3 ) 300 MHz 8.01 (d, j = 7.05 Hz, 2 H) , 7.58 (t, J = 7.86 Hz, 1 H) , 7.47 (t, J = 7.86 Hz, 2 H) , 7.31 (d, J = 8.46 Hz, 2 H) , 7.19 (d, 8.26 Hz, 2 H) , 4.26 (s, 2 H) . Step 2: Preparation of 2-bromo-2- ( -chlorophenyl) - 1-phenvlethanone To a stirred suspension of 2- (4-chlorophenyl) - 1-phenylethanone (Step 1) in HOAc (200 mL) and HBr/HOAc (35 mL, 33 wt%) was added Br 2 (2.3 mL, 7.16 g, 45 mmol) . The reaction was stirred for 2 hours and became homogeneous. Water and ethyl ether were added, mixed and the layers separated. The resulting organic phase was washed with water, NaHCθ 3 saturated εolution, brine, dried over MgS0 4 , filtered, diluted with isooctane and partially concentrated in vacuo which caused a precipitate to form. The suspension was filtered to yield the bromoketone as a white solid (10.38 g, 78%) which was εuitable for uεe in the next εtep without further purification: mp 57-59 °C. 1 H NMR (CDCI 3 ) 300 MHz 7.99 (d, J = 7.25 Hz, 2 HO, 7.59 (t, J = 7 . 20 Hz , 1 H) , 7 . 46 -7 . 41 (m 4 H) , 7 . 35 ( d, J = 8 . 46 Hz , 2 H) , 6 . 31 ( s , 1 H) . Step 3: Preparation of 5- (4-chlorophenyl) -2-methvl- 4-phenvlthiazole 2-Bromo-2- (4-chlorophenyl) -1-phenylethanone (Step 2) (1.10 g, 3.55 mmol) and thioacetamide (0.27 g, 3.55 mmol) were mixed in ethanol (25 mL) and stirred for 48 hours. The reaction was diluted with H 2 O and extracted with ethyl acetate. The combined ethyl acetate phases were washed with brine, dried over MgS0 4 , filtered, and concentrated in vacuo yielding the thiazole as a clear colorless oil (0.75 g, 74%). ^-H NMR (CDCI 3 ) 300 MHz 7.50- 7.44 (m, 2 H) , 7.33-7.23 (m, 7H) , 2.75 (s, 3 H) . LRMS M+H obs 286. Anal. Calc'd for C 16 H 12 CINS: C, 67.24; H, 4.23, N, 4.90. Found: C, 66.77; H, 4.23; N, 4.90. Step 4: Preparation of 4-r2-methvl-4- (5- chlorophenvl) -4-thiazolvllbenzeneεulfonamide To 5- (4-chlorophenyl) -2-methyl-4- phenylthiazole (Step 3) (0.2 g, 0.70 mmol) chilled in an ice bath was added neat chlorosulfonic acid (4 mL) . The reaction mixture was warmed to room temperature and reacted for 2 hours. The crude reaction mixture was diluted with dichloromethane (50 mL) and carefully poured over ice with vigorous stirring. The layers were separated and the dichloromethane phaεe waε washed with brine, dried over MgSθ 4 , and filtered. The filtrate was poured into rapidly stirred concentrated NH 4 OH (excesε) at room temperature and stirred overnight. The layers were separated and the aqueous phase was extracted with more dichloromethane. The organic phaseε were combined, washed with brine, dried over MgS04 and concentrated in vacuo yielding a solid. The solid was recrystallized from dichloromethane and isooctane yielding 4- [2-methy1-4- (5-chlorophenyl) - 4-thiazolyl]benzeneεulfonamide as white plates (0.072 g, 28%) : mp 221-223 °C. 1 H NMR (CDCI3) 300 MHz 7.84 (d, J = 8.66 Hz, 2 H) , 7.64 (d, J = 8.66 Hz, 2 H) , 7.32 (d, J = 8.46 Hz, 2 H) , 7.23 (d, J = 8.46 Hz, 2 H) , 4.76 (br. s, 2 H) , 2.76 (ε, 3 H) . LRMS M+H obε at m/z 365. Anal. Calc'd for C16H13CIN2O2S2: C, 52.67; H, 3.59, N, 7.68. Found: C, 52.51; H, 3.63; N, 7.62. Example 60 4- [4- ( 4-Chlorophenyl) -2-methyl-5 thiazolyl] benzenesulfonamide Step 1: Preparation of 4- (4-chlorophenvl ) -2-methvl- 5-phenvlthiazole HBr salt. To a stirred solution of 2-bromo-l- (4- chlorophenyl) -2-phenylethanone (Maybridge) (4.58 g, 15.04 mmol) in ethanol (100 mL) and CH3CN (15 mL) was added thioacetamide (1.186 g, 15.79 mmol) and the mixture was stirred at room temperature for 60 hourε. The reaction waε concentrated in vacuo yielding a yellow oil which cryεtallized upon standing. The solid was triturated with ethyl acetate and collected by vacuum filtration yielding 2-methyl-4- (4-chlorophenyl) -5-phenylthiazole HBr salt as a white powder (4.481 g, 81%) : mp 192-193 °C. 1 H NMR {CDCI3) 300 MHz 7.43 (d, J = 8.66Hz, 2 H) , 7.31 (s, 5 H) , 7.24 (d, J = 8.46 Hz, 2 H) , 2.75 (s, 3 H) . LRMS M+H m/z obs 286. HRMS M+H calc m/z 286.0457; obε M+H m/z 286.0448. Anal. Calc'd for Ci6Hi2ClNS'HBr-1.5 H 2 0: C, 48.41; H, 3.84, N, 3.55. Found: C, 48.96; H, 3.81; N, 4.00. Step 2: Preparation of 4- T4- (4-chlorophenyl) -2- methvl-5-thiazolvπbenzenesulfonamide To vigorouεly εtirred neat chlorosulfonic acid (5 mL) was added 4- (4-chlorophenyl) -2-methyl-5- phenylthiazole (Step 1) (0.56 g, 1.37 mmol) . After εtirring for 50 minutes, the crude reaction mixture was diluted with dichloromethane (40 mL) and carefully poured over ice. The layers were separated and the dichloromethane layer was poured into concentrated NH 4 OH (excesε) at room temperature and stirred overnight. The resulting material was diluted with aq aHC0 3 , and extracted with dichloromethane and then ethyl acetate. The organic phases were combined, washed with brine, dried over MgSθ 4 and concentrated in vacuo yielding 4- [2-methyl-4- [4-chlorophenyl] -5- thiazolyl]benzenesulfonamide as a white powder (0.275 g, 38%): mp 204-206 °C. ^-H NMR (CDCI3) 300 MHz 7.86 (d, J = 8.46 Hz, 2 H) , 7.45 (d, J = 8.46 Hz, 2 H) , 7.41 (d, J = 8.46, 2 H) , 7.29 ( d, J = 8.66 Hz, 2 H) , 4.81 (br s, 2 H) , 2.77 (s, 3 H) . LRMS M+H obs 365. HRMS M+H Calc'd m/z 365.0185, M+H obs m/ 365.0198. Anal. Calc'd for Cl6Hl3ClN2θS2'0.5 H 2 0: C, 51.51; H, 3.51. Found: C, 51.74; H, 3.67. Example 61 4- [5- (4-Bromophenyl) -2-methyl-4 thiazolyl]benzenes lfonamide Step 1: Preparation of 3- (4-bromophenvl) -2- phenvlpropenoic acid. Phenylacetic acid (53.50 g, 393 mmol), 4- bromobenzaldehyde (72.76 g, 393 mmol), triethylamine (43.11 g, 426 mmol), and acetic anhydride (350 mL) were combined and heated to 150 °C for 2 hourε and then cooled to 100 °C. Water (120 mL) waε εlowly added and an exotherm occurred followed by the precipitation of a yellow εolid. The εolid waε collected by vacuum filtration and waε recrystallized from toluene (400 mL) . The reεulting εolid was washed with hexanes yielding 3- (4-bromophenyl) -2-phenylpropenoic acid as a light yellow εolid (75.07 g, 63%): mp 203-206 °C. 1 H NMR (acetone-dβ) 7.80 (ε, 1 H) , 7.48-7.30 (m, 5 H) , 7.28-7.22(m, 2 H) , 7.10-7.02 (d, J = 8.46 Hz, 2 H) . LRMS M+H obε at m/z 301 and 303. Step 2: 2- (4-bromophenvl) -1-phenylethanone To a chilled (ice-bath) , stirred solution of 3- [4-bromophenyl] -2-phenylpropenoic acid (Step 1) (65.11 g, 215 mmol) in toluene (300 mL) was added Et 3 N (21.98 g, 217 mmol) and DPPA (59.50 g, 216 mmol) . The reaction was warmed to room temperature and stirred for over 2 hours. The reaction waε poured into water (400 mL) and the layerε were separated. The aqueous layer was extracted with Et 2 0 and the organic phaseε combined, waεhed with brine, dried over MgS0 , filtered and concentrated in vacuo to remove the Et 2 0. The reεulting εuεpension was heated to reflux for 1.3 hours causing the evolution of gas. Next, tert-butyl alcohol (21 mL, 18.75 g, 253 mmol) was added rapidly and after 40 minutes concentrated HCl (30 mL, 360 mmol) was added dropwise through the condenser over 20 minutes. The reaction was stirred at 110 °C for 1 hour and cooled to room temperature and a precipitate formed. The precipitate was collected by vacuum filtration to yield 2- (4-bromophenyl) -1-phenylethanone aε a white εolid (20.74 g, 35%) . A εecond crop was. obtained by concentrating the filtrate in vacuo and recrystallizing the residue from ethyl acetate/hexane to yield an additional 12.07 g (20%): mp 141-144 °C. 1 H NMR (acetone-dβ) 8.07 (d, J = 7.25 Hz, 2 H) , 7.71-7.45 (m, 5 H) , 7.28 (d, J = 8.46 Hz, 2 H) , 4.40 (s, 2 H) . LRMS M+Li obs at m/z 281. Step 3: Preparation of 2-bromo-2- (4-bromophenvl) -1- phenvlethanone To a stirred suεpenεion of 2- (4-bromophenyl) - 1-phenylethanone (Step 2) (20.59 g, 74.8 mmol) in HOAc (150 mL) and HBr/HOAc (30 wt%, 25 mL) was added Br 2 (4 mL, 77.6 mmol) and within 1 hour the reaction became homogeneous. After 1.75 hours, the reaction suspenεion waε filtered yielding a white εolid and filtrate. The filtrate was treated with 10% NaHS0 3 until the Br 2 color waε extinguished and a precipitate formed which was collected and combined with the above solid. This solid was disεolved in ethyl acetate, washed with water, 10 % NaHSθ3, εaturated, NaHCθ3, brine, dried over MgSO^ j , filtered and concentrated in vacuo yielding a white εolid (20.42 g, 77 %) : ^-H NMR (acetone-d 6 ) 8.13 (d, J = 8.26 Hz, 2 H) , 7.75-7.50 (m, 7 H) , 6.94 (s, 1 H) . LRMS M+Li obs at m/z 359/361/363. Step 4: Preparation of 5- r -bromopheny11 -2-methyl- 4-phenvlthiazole To a stirred solution of 2-bromo-2- (4- bromophenyl) -1-phenylethanone (Step 3) (2.04 g, 5.80 mmol) in EtOH (40 mL) was added thioacetamide (0.46 g, 6.09 mmol) and the solution was stirred for 24 hourε. The reaction waε concentrated in vacuo, the reεidue diεεolved in dichloromethane (125 mL) and waεhed with εaturated NaHC03 εolution (3 X 25 mL) and brine (50 mL) , dried over MgS04, filtered and concentrated in vacuo yielding an oil. The oil waε purified by flash chromatography (hexanes:EtOAc, 10:1) yielding 5- (4-bromophenyl) - 2-methyl-4-phenylthiazole (1.262 g, 66%) as a clear colorless oil which was sufficiently pure to utilize in the next step: 1 H NMR (CDCI3) 7.50- 7.45 (m, 2 H) , 7.43 (d, J = 8.66 Hz, 2 H) , 7.33- 7.26 (m, 3 H) , 7.18. (d, J = 8.46 Hz, 2 H) , 2.75 (ε, 3 H) . Step 5: Preparation of 4- \ 5- (4-bromophenvl) -2- methvl-4-thiazolvl1benzenesulfonamide To neat chloroεulfonic acid (10 mL) under nitrogen, chilled to -12 °C in a NaCl/ice bath waε added 5- [4-bromophenyl] -2-methyl-4-phenylthiazole (Step 4) (1.00 g, 3.03 mmol) dropwise aε a warm moderately viεcouε oil. After 2 hourε at -10 °C, the reaction waε warmed to 0 °C and εtirred for 1.5 hourε. The clear green reaction solution was poured over ice yielding a precipitate which was collected by vacuum filtration. This solid was disεolved in dichloromethane (75 mL) , mixed with concentrated NH4OH (8 mL) at 0°C and εtirred for 2 hours. The reaction was diluted with dichloromethane (50 mL) and brine (50 mL) . The layers were separated, and the organic phase waεhed with 1 N HCI, NaHCθ3 (εaturated aq) , brine, dried over MgSθ , filtered and concentrated in vacuo yielding a pale yellow εolid. This solid was recrystallized from ethyl acetate/hexane yielding 4- [2-methyl-5- (4-bromophenyl) -4- thiazolyl]benzeneεulfonamide as a white powder (0.232 g, 19%) : mp 207-209 °C. X H NMR (CDCI3) 300 MHz 7.83 (d, J = 8.66 Hz, 2 H) , 7.63 (d, J = 8.66 Hz, 2 H) , 7.47 (d, J = 8.66 Hz), 7.17 ( d, J = 8.66 Hz, 2 H) , 4.85 (br s, 2 H) , 2.77 (ε, 3 H) . LRMS M+H obs at m/z 409. HRMS M+H Calc'd m/z 408.968, M+H obs m/z 408.9681. Anal. Calc'd for C 16 H 13 BrN 2 0 2 S 2 -1.5 H 2 0 C, 44.04; H, 3.00; N, 6.42. Found: C, 44.20; H, 3.40; N, 6.53. Example 62 4- (2-Methyl-5-phenyl-4- thiazolyl)benzenesulfonamide To a solution of 4- [2-methyl-5- (4- bromophenyl) -4-thiazolyl]benzenesulfonamide (Example 61) in methanol (10 mL) , THF (2 mL) , and HOAc (0.5 mL) was added 5% Pd/C (0.060 g) . The reaction was charged with H 2 (50 psi) and stirred overnight. The suεpenεion was filtered through diatomaceous earth. The filtrate was concentrated in vacuo yielding 4- (2-methy1-5-phenyl-4- thiazolyl)benzeneεulfonamide as a solid (0.134 g, 52%) : mp 238-239 °C. NMR (CD 3 OD) 300 MHz 7.86 (d, J = 8.46 Hz, 2 H) , 7.61 (d, J = 8.46 Hz, 2 H) , 7.46-7.27 (m, 5 H) , 2.85 (s, 3 H) . LRMS (M+H obε at m/z 331) . HRMS M+H Calc'd m/z 331.0575, obε M+H m/z 331.0566. Example 63 4- [2-Benzylamino-4- ( 3-fluoro-4- methoxyphenyl ) -5-thiazolyl]benzenesulfonamide Step 1: Preparation of 1- (4-methoxv-3- fluorophenvl) -2-phenylethanone To a chilled (ice bath) suspension of 2- fluoroaniεole (35.90 g, 0.285 mol) and AlCl 3 (37.95 g, 0.285 mol) in chloroform (CHC1 3 ) (500 mL) was added phenylacetyl chloride dropwise maintaining the temperature below 5 °C. After stirring for 2 hours, the reaction was poured over ice, the layers εeparated, and the organic phaεe waε waεhed with 1 N HCI, brine, and water, dried over MgSO^, filtered and concentrated. The crude product waε recryεtallized from ethyl acetate/hexane yielding 1- (4-methoxy-3-fluorophenyl) -2-phenylethanone a white solid (65 g, 93 %) which was used without further purification. Step 2: Preparation of 1- (4-methoxv-3- fluorophenvl) -2- (4-aminosulfonvlphenvl) ethanone To 1- (4-methoxy-3-fluorophenyl)-2- phenylethanone (Step 1) (65 g, 0.266 mol) was added chlorosulfonic acid (150 mL, 263 g, 2.25 mol) and the solution was stirred for 3 hours. This εolution waε carefully poured dropwise over ice and the aqueous phase was extracted with dichloromethane. The dichloromethane phase waε added to rapidly εtirred NH4OH (concentrated 200 mL) and the mixture waε εtirred overnight. The reεulting εuspension was filtered and the solid waε triturated with hot acetone yielding the εulfonamide as a light yellow solid (12.0 g, 14 %) which was used without further purification. Step 3: Preparation of 2-bromo-l- (4-methoxv-3- fluorophenvl) -2- (4-aminosulfonvlphenvl) -ethanone To a mixture of 1-[4-methoxy-3-fluorophenyl]- 2- (4-aminoεulfonylphenyl)-ethanone (11.4 g, 0.035 mol) in HOAc (200 mL) and HBr in HOAc (33 % solution, 50 mL) was added Br 2 (5.6 g, 0.035 mol). The mixture was heated at reflux for 4 hours, cooled to room temperature, and poured into water yielding the crude bromo ketone as a white precipitate (12.1 g, 90 %) which was used without further purification: mp 137-141 °C. Step 4: Preparation of 4-r2-benzvlamino-4-(3- fluoro-4-methoxyphenyl)- - thiazolvl1benzenesulfonamide To a stirred solution of 2-bromo-l- (4-methoxy- 3-fluorophenyl) -2- (4-aminoεulfonylphenyl) -ethanone (Step 3) (0.383 g, 0.952 mmol) in CH3CN (5 mL) waε added N-benzylthiourea (0.158 g, 0.952 mmol) in one portion and the reaction waε stirred for 60 hourε at room temperature. The reaction waε concentrated in vacuo and partitioned between ethyl acetate and H 2 0. The ethyl acetate phase was dried over MgSθ4, filtered and concentrated in vacuo. The crude product was purified by flash chromatography eluting with hexanes:ethyl acetate (2:1) yielding 4- [2-benzylamino-4- [3-fluoro-4-methoxyphenyl] -5- thiazolyl]benzenesulfonamide as a solid (0.161 g, 36%) : mp 199-200 °C. ^-H NMR (CDCl 3 /DMSO-d 6 ) 300 MHz 7.76 (d, J = 8.66 Hz, 2 H) , 7.42-7.28 (m, 7 H) , 7.26-7.21 (m, IH) , 7.16-7.09 (m, 1 H) , 6.82 (t, J = 8.98 Hz, 1 H) , 5.89 (br t, J = 5.64, 1 H) , 5.62 (s, 2 H) , 4.51 (d, J = 5.64 Hz, 2 H) , 3.87 (ε, 3 H) . LRMS M+H obs at m/z 470. HRMS M+H calc m/z 470.1008, obε m/z 470.1022. Example 64 4- [2- [2 -Chlorophenyl] -4- [3-f luoro- 4 - methoxyphenyl ] -5 -thiazolyl] benzenesulfonamide To a stirred solution of 2-bromo-l- (4-methoxy- 3 -fluorophenyl) -2- ( 4 -aminosulf onylphenyl) ethanone (0.387 g, 0.962 mmol) (Example 63, Step 3) in CH3CN (5 mL) was added o-chlorothiobenzamide (0.165 g, 0.962 mmol) in one portion and the reaction mixture was stirred for 60 hours at room temperature . The yellow suεpenεion was concentrated in vacuo . The solid was suspended in ethanol and collected by vacuum filtration yielding 4- [2- (2-chlorophenyl) -4- (3-fluoro-4-methoxyphenyl) -5- thiazolyl]benzenesulfonamide as a pale yellow solid (0.147 g, 32%) : mp 214-216 °C. 1 H NMR (CDCl 3 /DMSO- d 6 ) 300 MHz 7.85 (d, J = 8.26 Hz, 2 H) , 7.75-7.72 (m, 1 H) , 7.71-7.64 (m, 1 H) , 7.52-7.42 (m, 2 H) , 7.38-7.30(m, 4 H) , 6.97 (t, J = 8.24 Hz, 1 H) , 5.85 (br s, 2 H) , 3.92 (s, 3 H) . LRMS M+H obs at m/z 475. HRMS M+H Calc'd m/z 475.0353; M+H obs m/z 475.0352. Example 65 4- [4- ( 3-Fluoro-4-methoxyphenyl) -2-methyl-5 thiazolyl]benzenesulfonamide To a stirred solution of 2-bromo-l- (4-methoxy- 3-fluorophenyl) -2- (4-aminosulfonylphenyl)ethanone (0.440 g, 0.1.094 mmol) (Example 63, Step 3) in CH3CN (5 mL) was added thioacetamide (0.082 g, 1.094 mmol) in one portion and the reaction waε εtirred for 60 hours at room temperature. The reaction waε concentrated in vacuo and partitioned between ethyl acetate and H 0. The ethyl acetate phaεe waε dried over MgS04, filtered and concentrated in vacuo. The crude product was purified by flash chromatography, eluting with hexanes:ethyl acetate (1:1), yielding 4-[2-methyl- 4- [3-fluoro-4-methoxyphenyl] -5- thiazolyl]benzeneεulfonamide aε a solid (0.061 g, 15%) : mp 168-175 °C. ^-H NMR (CDCI3) 300 MHz 7.87 (d, J = 8.66 Hz, 2 H) , 7.46 (d, J = 8.66 Hz, 2 H) , 7.29-7.22 (m, 1 H) , 7.17-7.12 (m, 1 H) , 6.87 (t, J = 9.07, 1 H) , 4.82 (br s, 2 H) , 3.90 (s, 3 H) , 2.76 (s, 3 H) . LRMS M+H obε at m/z 379. HRMS M+H calc m/z 379.0586, M+H obs m/z 379.0605. Anal. Calc'd for C 17 H 15 FN 2 0 3 S 2 , C, 53.96; H, 4.00; Found C, 53.69; H, 4.17. Example 66 4- (2-Methyl-4-phenyl-5- thiazolyl) benzenesulfonamide Step 1: Preparation of 2-methvl-3.4- diphenvlthiazole To a suεpension of lithium chloride (12.56 g, 296.35 mmol) and benzoin (12.58 g, 59.27 mmol) in DMF (100 mL) waε added Et 3 N (9.0 g, 88.90 mmol) . The reaction was cooled with a water bath and methanesulfonyl chloride (6.9 mL, 10.18 g, 88.9 mmol) was added over 0.08 hour. The reaction became a pale yellow suεpenεion. After εtirring for 2 hourε, additional Et 3 N (9.0 g, 88.90 mmol) and methaneεulfonyl chloride (6.9 mL, 10.18 g, 88.9 mmol) were added. In 2 hourε, the reaction waε complete and waε diluted with Et 2 θ (500 mL) , waεhed with brine, dried over Na 2 Sθ 4 , filtered and concentrated yielding an orange oil. Thiε oil waε diεεolved in ethanol (120 mL) and thioacetamide added and the reaction was stirred at room temperature for 5 days, then heated to reflux for 2 hours. The reaction was cooled to room temperature, diluted with H 2 O, yielding an oily product. This oil was purified by flash chromatography, yielding an oil which slowly crystallized to form an orange solid (1.81 g, 12%). This material was suitable to use without further purification: mp 45-49 °C. ^-H NMR (CDCI 3 ) 300 MHz 7.57-7.48 (m, 2 H) , 7.35-7.26 (m, 8 H) , 2.76 (s, 3 H) . Step 2: Preparation of 4-(2-methvl-4-phenvl-5- - thiazolvl)benzenesul onamide To εtirred chlorosulfonic acid (1.3 mL, 19.89 mmol) chilled in a NaCl/ice bath was added 3,4- diphenyl-2-methylthiazole (Step 1) (1.00 g, 3.98 mmol) . The reaction was warmed to room temperature and stirred for 2 hours. Additional chlorosulfonic acid (4 mL) was added and the reaction proceeded at room temperature for 0.5 hour. The dark mixture was carefully poured over ice. The aqueous phase waε decanted from the oily layer and waε extracted with dichloromethane. The organic phaεe waε combined with the oily reεidue and poured into concentrated NH 4 OH. After 4 hourε, the mixture was diluted with dichloromethane, the layerε εeparated, and the dichloromethane phaεe waεhed with aq KHSO 4 εolution, aq NaHC0 3 , brine, filtered and concentrated in vacuo yielding an orange εolid. Thiε εolid was triturated with dichloromethane and collected by vacuum filtration yielding 4- (2- methyl-4-phenyl-5-thiazolyl)benzenesulfonamide as a tan solid (0.432 g, 33%) : mp 212-214 °C. 1 H NMR (CDCI 3 with CD 3 OD) 300 MHz 7.81 (d, J = 8.66 Hz, 2 H) , 7.46-7.38 (m, 4 H) , 7.33-7.27 (m, 3 H) , 5.42 (br s, <1/ partially exchanged), 2.76 (s, 3 H) . LRMS M+H obε at m/z 331. HRMS M+H Calc'd m/z 331.0575, obε M+H m/z 331.0561. BIOLOGICAL EVALUATION Rat Carrageenan Foot Pad Edema Test The carrageenan foot edema test was performed with materials, reagents and procedures esεentially as described by Winter, et al., { Proc. Soc. Exp . Biol . Med. , 111, 544 (1962)) . Male Sprague-Dawley rats were selected in each group so that the average body weight was as close as posεible. Ratε were fasted with free accesε to water for over sixteen hours prior to the test. The rats were dosed orally (1 ml) with compounds suspended in vehicle containing 0.5% methylcellulose and 0.025% surfactant, or with vehicle alone. One hour later a subplantar injection of 0.1 ml of 1% solution of carrageenan/sterile 0.9% εaline waε administered and the volume of the injected foot was measured with a diεplacement plethyεmometer connected to a preεεure tranεducer with a digital indicator. Three hourε after the injection of the carrageenan, the volume of the foot was again measured. The average foot swelling in a group of drug-treated animals was compared with that of a group of placebo-treated animals and the percentage inhibition of edema waε determined (Otterneεε and Bliven, Laboratory Models for Testing NSAIDs , in Non-steroidal Anti -Inflammatory Drugs, (J. Lombardino, ed. 1985)). The % inhibition shows the % decrease from control paw volume determined in this procedure and the data for selected compounds in thiε invention are εummarized in Table I. Rat Carrageenan-induced Analgesia Test The rat carrageenan analgesia test was performed with materials, reagentε and procedureε eεεentially aε deεcribed by Hargreaveε, et al., { Pain, 32, 77 (1988)). Male Sprague-Dawley ratε were treated as previously described for the Carrageenan Foot Pad Edema test. Three hours after the injection of the carrageenan, the rats were placed in a εpecial plexiglass container with a transparent floor having a high intensity lamp as a radiant heat source, positionable under the floor. After an initial twenty minute period, thermal εtimulation waε begun on either the injected foot or on the contralateral uninjected foot. A photoelectric cell turned off the lamp and timer when light waε interrupted by paw withdrawal. The time until the rat withdrawε its foot was then measured. The withdrawal latency in secondε waε determined for the control and drug-treated groupε, and percent inhibition of the hyperalgeεic foot withdrawal determined. Reεults are shown in Table I. TABLE Ri \.T PAW EDEMJ . ANALGESIA % Inhibit: Lon % Inhibition @ 20mσ/kσ body weiσht @ 20mσ/kσ body weiσht Examples 8 12 - 10 14 - 12 53 - 16 50 27 20 48 - 23 39.5 - 24 20* - 29 42 24 31 27.5* - 33 36 34a 35 16 - 37 9 - 39 19 - 41 4 - 45 19* - 46 25* - 47 12 - 48 15* - 49 6* - 50 11* - 51 14* - 52 7* - 56 20* - 57 2* - * & lOmg/kg a @ 30mg/kg Evaluation of COX I and COX II activity in vi tro The compounds of thiε invention exhibited inhibition in vi tro of COX II. The COX II inhibition activity of the compoundε of thiε invention illustrated in the Examples was determined by the following methods. a. Preparation of recombinant COX baculoviruses Recombinant COX-1 and COX-2 were prepared as described by Gierεe et al, [J " . Biochem . , 305, 479-84 (1995)]. A 2.0 kb fragment containing the coding region of either human or murine COX-1 or human or murine COX-2 was cloned into a BamHl site of the baculoviruε tranεfer vector pVLl393 (Invitrogen) to generate the baculoviruε transfer vectors for COX-1 and COX-2 in a manner similar to the method of D.R. O'Reilly et al (Baculovirus Expression Vectors : A Laboratory Manual (1992)). Recombinant baculoviruseε were isolated by transfecting 4 μg of baculoviruε tranεfer vector DNA into SF9 inεect cellε (2xl0 8 ) along with 200 ng of linearized baculoviruε plaεmid DNA by the calcium phosphate method. See M.D. Summerε and G.E. Smith, A Manual of Methods for Baculovirus Vectors and Insect Cell Cul ture Procedures, Texaε Agric. Exp. Station Bull. 1555 (1987). Recombinant viruεeε were purified by three roundε of plaque purification and high titer (10 7 - 10^ pfu/ml) εtocks of virus were prepared. For large scale production, SF9 insect cellε were infected in 10 liter fermentorε (0.5 x 10^/ml) with the recombinant baculoviruε εtock εuch that the multiplicity of infection waε 0.1. After 72 hours the cells were centrifuged and the cell pellet homogenized in Tris/Sucroεe (50' mM: 25%, pH 8.0) containing 1% 3- [ (3-cholamidopropyl)dimethylammonio]-1-propaneεulfonate (CHAPS). The homogenate waε centrifuged at 10,000xG for 30 minuteε, and the resultant εupernatant waε εtored at -80°C before being aεεayed for COX activity. b. Assay for COX I and COX II activity: COX activity was assayed as PGE 2 formed/μg protein/time using an ELISA to detect the prostaglandin released. CHAPS-solubilized insect cell membranes containing the appropriate COX enzyme were incubated in a potasεium phoεphate buffer (50 mM, pH 8.0) containing epinephrine, phenol, and heme with the addition of arachidonic acid (10 μM) . Compoundε were pre-incubated with the enzyme for 10-20 minuteε prior to the addition of arachidonic acid. Any reaction between the arachidonic acid and the enzyme waε εtopped after ten minuteε at 37°C/room temperature by transferring 40 μl of reaction mix into 160 μl ELISA buffer and 25 μM indomethacin. The PGE 2 formed was measured by standard ELISA technology (Cayman Chemical) . Reεults are shown in Table II. TABLE II. Species COX I cox II murine (m) /human (h) IDς μM IP50—UW [_ Examples 1 m >100 0.1 h >10 <0.1 2 h >100 <0.1 3 h >100 <0.1 4 m 6.2 <0.1 h 70 <0.1 5 h >100 <0.1 6 h >100 <0.1 7 h >100 <0.1 8 m >100 0.2 9 h >100 <0.1 10 h >100 <0.1 11 h >100 <0.1 TABLE I I . ( cont . ) Species COX I COX II murine (m) /human (h) ID50 μM IP51 LLH Examples 12 m 1.6 <0.1 h >10 <0.1 13 m >30 1.2 14 m 39.8 0.5 h >100 0.6 15 h >100 0.2 16 m >10 <0.1 h >100 <0.1 17 m >10 0.3 18 m 5.4 0.1 19 m .4 <0.1 20 m >10 0.1 21 m >10 <0.1 h >10 <0.1 22 m >100 11.2 23 m .7 <0.1 h 1.1 <0.1 24 m >10 <0.1 25 h 2.6 <0.1 26 m >100 0.5 27 m >10 0.2 28 >10 <0.1 29 m .5 0.1 30 m .9 0.3 31 m >10 0.1 32 h 0.7 <0.1 33 h >100 <0.1 34 h <0.1 <0.1 35 m >100 <0.1 36 h >100 <0.1 37 m >100 <0.1 TABLE II. (cont.. ) Species COX I COX II murine (m) /human (h ID50 μM I ejO UM Examples 38 h >100 <0.1 39 m >10 0.3 40 h >100 <0.1 41 h >100 <0.1 42 m 1.9 <0.1 43 m 100 1.3 44 m 1.7 <0.1 45 m >100 <0.1 46 m 1.4 <0.1 47 m 1.4 <0.1 48 m >10 0.3 49 m >10 0.3 50 m >10 0.3 51 m 11.9 0.3 52 m >100 0.5 53 m 0.2 0.9 54 m 1.1 1.3 55 m >10 3.5 56 m >100 <0.1 56 h >100 <0.1 57 m 4.9 <0.1 h >100 <0.1 58 h >100 0.3 59 h • 35.6 <0.1 61 h 100 <0.1 63 h <0.1 <0.1 64 h 2.5 >100 Biological paradigms' for teεting the cytokine- inhibiting activity of theεe compounds are found in WO95/13067, published 18 May 1995. Alεo embraced within this invention is a class of pharmaceutical compoεitionε compriεing the active compounds of this combination therapy in association with one or more non-toxic, pharmaceutically-acceptable carriers and/or diluents and/or adjuvants (collectively referred to herein as "carrier" materials) and, if desired, other active ingredients. The active compounds of the present invention may be administered by any suitable route, preferably in the form of a pharmaceutical composition adapted to such a route, and in a doεe effective for the treatment intended. The active compounds and composition may, for example, be administered orally, intravascularly, intraperitoneally, subcutaneously, intramuεcularly or topically. For oral administration, the pharmaceutical composition may be in the form of, for example, a tablet, capsule, suspenεion or liquid. The pharmaceutical compoεition iε preferably made in the form of a doεage unit containing a particular amount of the active ingredient. Exampleε of εuch doεage unitε are tabletε or capsules. The active ingredient may also be administered by injection as a composition wherein, for example, saline, dextrose or water may be used as a suitable carrier. The amount of therapeutically active compounds that are adminiεtered and the dosage regimen for treating a diseaεe condition with the compounds and/or compoεitionε of this invention depends on a variety of factors, including the age, weight, sex and medical condition of the subject, the severity of the disease, the route and frequency of administration, and the particular compound employed, and thus may vary widely. The pharmaceutical compositionε may contain active ingredientε in the range of about 0.1 to 2000 mg, preferably in the range of about 0.5 to 500 mg and moεt preferably between about 1 and 100 mg. A daily doεe of about 0.01 to 100 mg/kg body weight, preferably between about 0.5 and about 20 mg/kg body weight and moεt preferably between about 0.1 to 10 mg/kg body weight, may be appropriate. The daily doεe can be adminiεtered in one to four doses per day. In the caεe of psoriasis and other skin conditions, it may be preferable to apply a topical preparation of compounds of this invention to the affected area two to four times a day. For inflammations of the eye or other external tissues, e.g., mouth and skin, the formulations are preferably applied aε a topical ointment or cream, or aε a suppository, containing the active ingredients in a total amount of, for example, 0.075 to 30% w/w, preferably 0.2 to 20% w/w and moεt preferably 0.4 to 15% w/w. When formulated in an ointment, the active ingredientε may be employed with either paraffinic or a water-miεcible ointment base. Alternatively, the active ingredients may be formulated in a cream with an oil-in- water cream base. If desired, the aqueous phaεe of the cream baεe may include, for example at leaεt 30% w/w of a polyhydric alcohol εuch aε propylene glycol, butane-1,3- diol, mannitol, εorbitol, glycerol, polyethylene glycol and mixtureε thereof. The topical formulation may deεirably include a compound which enhanceε abεorption or penetration of the active ingredient through the εkin or other affected areaε. Examples of such dermal penetration enhancers include dimethylsulfoxide and related analogε. The compoundε of thiε invention can alεo be adminiεtered by a transdermal device. Preferably topical administration will be accomplished using a patch either of the reservoir and porouε membrane type or of a solid matrix variety. In either case, the active agent is delivered continuously from the reservoir or microcapsules through a membrane into the active agent permeable adhesive, which is in contact with the skin or mucosa of the recipient. If the active agent is absorbed through the skin, a controlled and predetermined flow of the active agent is administered to the recipient. In the caεe of microcapεuleε, the encapεulating agent may alεo function as the membrane. The oily phase of the emulsions of this invention may be conεtituted from known ingredients in a known manner. While the phase may comprise merely an emulsifier, it may comprise a mixture of at least one emulsifier with a fat or an oil or with both a fat and an oil. Preferably, a hydrophilic emulsifier is included together with a lipophilic emulsifier which acts as a stabilizer. It is also preferred to include both an oil and a fat. Together, the emulsifier(ε) with or without stabilizer(ε) make-up the εo-called emulεifying wax, and the wax together with the oil and fat make up the εo- called emulεifying ointment baεe which formε the oily diεperεed phaεe of the cream formulations. Emulsifierε and emulεion εtabilizerε εuitable for uεe in the formulation of the present invention include Tween 60, Span 80, cetostearyl alcohol, myriεtyl alcohol, glyceryl monostearate, and sodium lauryl sulfate, among others. The choice of εuitable oils or fats for the formulation is based on achieving the deεired cosmetic properties, since the solubility of the active compound in moεt oilε likely to be uεed in pharmaceutical emulεion formulations is very low. Thus, the Cream should preferably be a non-greasy, non-staining and washable product with suitable consiεtency to avoid leakage from tubes or other containers. Straight or branched chain, mono- or dibasic alkyl esterε εuch aε di-iεoadipate, iεocetyl εtearate, propylene glycol dieεter of coconut fatty acids, isopropyl myristate, decyl oleate, isopropyl palmitate, butyl stearate, 2- ethylhexyl palmitate or a blend of branched chain esterε may be uεed. These may be used alone or in combination depending on the properties required. Alternatively, high melting point lipids εuch as white soft paraffin and/or liquid paraffin or other mineral oils can be used. Formulationε εuitable for topical administration to the eye alεo include eye dropε wherein the active ingredientε are diεεolved or suspended in suitable carrier, eεpecially an aqueouε solvent for the active ingredients. The antiinflammatory active ingredientε are preferably present in such formulations in a concentration of 0.5 to 20%, advantageously 0.5 to 10% and particularly about 1.5% w/w. For therapeutic purposes, the active compounds of this combination invention are ordinarily combined with one or more adjuvants appropriate to the indicated route of administration. If administered per oε, the compounds may be admixed with lactose, sucroεe, εtarch powder, celluloεe esterε of alkanoic acids, cellulose alkyl esters, talc, stearic acid, magnesium stearate, magnesium oxide, εodium and calcium salts of phosphoric and sulfuric acids, gelatin, acacia gum, sodium alginate, polyvinylpyrrolidone, and/or polyvinyl alcohol, and then tableted or encapsulated for convenient administration. Such capsules or tablets may contain a controlled-release formulation as may be provided in a disperεion of active compound in hydroxypropyImethyl celluloεe. Formulations for parenteral administration may be in the form of aqueous or non-aqueous iεotonic εterile injection solutions or suspensions. These solutions and suεpenεions may be prepared from sterile powders or granules having one or more of the carriers or diluents mentioned for use in the formulations for oral adminiεtration. The compoundε may be diεsolved in water, polyethylene glycol, propylene glycol, ethanol, corn oil, cottonseed oil, peanut oil, sesame oil, benzyl alcohol, sodium chloride, and/or various buffers. Other adjuvants and modeε of administration are well and widely known in the pharmaceutical art. Although this invention has been described with respect to specific embodiments, the details of these embodiments are not to be construed aε limitationε.

Claims: What is claimed is: 1. A compound of Formula I wherein R 1 is selected from hydrido, halo, amino, alkoxy, cyano, nitro, hydroxyl, aminocarbonyl, acyl, alkylaminocarbonyl, arylaminocarbonyl, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, alkylamino, arylamino, aralkylamino, carboxyl, carboxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkylaminoalkyl, heterocycloalkyl, aralkyl, hydroxyalkyl, alkoxyalkyl, cyanoalkyl, N-alkylsulfonylamino, heteroarylsulfonylaikyl, heteroarylsulfonylhaloalkyl, aryloxyalkyl, aralkyloxyalkyl, aryl and heterocycio, where the aryl and heterocycio radicals are optionally substituted at a substitutable position with one or more radicals selected from halo, alkyl, alkoxy, alkylthio, alkylsulfinyl, haloalkyl, haloalkoxy, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, amino, acyl and alkylamino; and wherein R 2 and R 3 are independently selected from alkyl, alkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R 2 and R 3 are optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, aminosulfonyl, alkyl, alkenyl, alkynyl, cyano, carboxyl, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, acyl, N-alkylaminocarbonyl, N-arylaminocarbonyl, N,N- dialkylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, haloalkyl, hydroxyl, alkoxy, alkoxyalkyl, hydroxyalkyl, haloalkoxy, amino, N-alkylamino, N,N- dialkylamino, heterocyclic and nitro; provided one of R 2 and R 3 is aryl substituted with alkylsulfonyl, haloalkylsulfonyl or aminosulfonyl; further provided that R 2 is not 4- fluorophenyl when R 1 is methyl and R 3 is 4- methylsulfonylphenyl; further provided that R 3 is not 4-fluorophenyl when R 1 is methyl and R 2 is 4- aminoεulfonylphenyl; further provided R 2 and R 3 are not phenyl substituted with α,oc-bis (methyl) ethanol; and further provided that R 2 is not 4- (methylsulfonyl)phenyl when R 1 is α,α -bis (trifluoromethyl)methanol; or a pharmaceutically-acceptable salt thereof. 2. Compound of Claim 1 wherein R 1 is selected from hydrido, halo, amino, lower alkoxy, cyano, nitro, hydroxyl, aminocarbonyl, acyl, lower alkylaminocarbonyl, phenylaminocarbonyl, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, lower haloalkoxy, lower alkylamino, phenylamino, lower aralkylamino, carboxyl, lower carboxyalkyl, lower alkoxycarbonyl, lower alkoxycarbonylalkyl, lower alkylaminoalkyl, lower heterocycloalkyl, lower aralkyl, lower cyanoalkyl, lower N-alkylsulfonylamino, lower heteroarylsulfonylaikyl, lower heteroarylsulfonylhaloalkyl, lower aryloxyalkyl, lower aralkyloxyalkyl, aryl and heterocycio, wherein the aryl and heterocycio radicals are optionally substituted at a subεtitutable position with one or more radicals selected from halo, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower haloalkyl, lower haloalkoxy, lower carboxyalkyl, lower alkoxycarbonyl, aminocarbonyl, amino, acyl and lower alkylamino; and wherein R 2 and R 3 are independently selected from lower alkyl, lower alkenyl, aryl, lower cycloalkyl, lower cycloalkenyl and heterocyclic; wherein R 2 and R 3 are optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, lower alkenyl, lower alkynyl, cyano, carboxyl, lower carboxyalkyl, lower alkoxycarbonyl, aminocarbonyl, acyl, lower N- alkylaminocarbonyl, N-arylaminocarbonyl, lower N,N- dialkylaminocarbonyl, lower N-alkyl-N- arylaminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, amino, lower alkylamino, heterocyclic and nitro; or a pharmaceutically-acceptable salt thereof. 3. Compound of Claim 2 wherein R 1 is selected from fluoro, chloro, bromo, iodo, amino, methoxy, ethoxy, propoxy, butoxy, isopropoxy, tert-butoxy, cyano, nitro, hydroxy, aminocarbonyl, formyl, acetyl, N-methylaminocarbonyl, N-phenylaminocarbonyl, N,N- dimethylaminocarbonyl, N-methyl-N-phenylaminocarbonyl, methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, tert-butyl, ethylenyl, propylenyl, butenyl, pentenyl, isopropylenyl, isobutylenyl, propargyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, N-methylamino, N-ethylamino, N- propylamino, N-butylamino, N-tert-butylamino, N- pentylamino, N-hexylamino, N,N-dimethylamino, carboxyl, N-benzylamino, 3, 5-dichlorophenylamino, 3,5- dichlorophenoxymethyl, 3-chlorophenoxymethyl, carboxymethyl, methoxycarbonyImethyl, ethoxycarbonyImethyl, methylaminomethyl, morpholinomethyl, pyrrolidinyImethyl, piperazinyImethyl, piperidinyImethyl, pyridyImethyl, thienyImethyl, benzyl, phenethyl, phenylpropyl, cyanomethyl, phenoxymethyl, benzyloxymethyl, methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl, tert-butoxycarbonyl, propoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, pentoxycarbonyl, N- methylεulfonylamino, (2-thienyl) sulfonyImethyl, (2- thienyl) sulfonylbromomethyl, phenyl optionally substituted at a substitutable position with one or more radicals selected from fluoro, chloro, bromo, methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, tert-butyl, methoxy, ethoxy, propoxy, butoxy, isopropoxy, ter -butoxy, methylthio, methylsulfinyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, carboxymethyl, methoxycarbonyl, ethoxycarbonyl, aminocarbonyl, amino, formyl, methylamino and dimethylamino, and heterocyclic selected from morpholino, pyrrolidinyl, piperazinyl, piperidinyl, pyridyl, thienyl, thiazolyl, oxazolyl, pyrimidinyl, pyrazinyl, quinolyl, isoquinolyl, imidazolyl, and benzimidazolyl, furyl, pyrrolyl, pyrazolyl and triazolyl, optionally substituted at a substitutable position with one or more radicals selected from fluoro, chloro, bromo, methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, tert- butyl, methoxy, ethoxy, propoxy, butoxy, isopropoxy, terfc-butoxy, methylthio, methylsulfinyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, carboxymethyl, methoxycarbonyl, ethoxycarbonyl, aminocarbonyl, amino, formyl, methylamino and dimethylamino; and wherein R 2 and R 3 are independently selected from methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, tert- butyl, ethylenyl, propylenyl, butenyl, pentenyl, isopropylenyl, isobutylenyl, phenyl, naphthyl, biphenyl, pyridyl, thienyl, thiazolyl, oxazolyl, pyrimidinyl, pyrazinyl, quinolyl, isoquinolinyl, imidazolyl, benzimidazolyl, furyl, pyrrolyl, pyrazolyl, triazolyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, morpholino, pyrrolidinyl, piperazinyl and piperidinyl; wherein R 2 and R 3 are optionally substituted at a substitutable position with one or more radicals selected from fluoro, chloro, bromo, methylthio, methylsulfinyl, methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, tert-butyl, ethylenyl, propylenyl, butenyl, pentenyl, isopropylenyl, isobutylenyl, propargyl, cyano, carboxyl, carboxymethyl, methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl, tert- butoxycarbonyl, propoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, pentoxycarbonyl, aminocarbonyl, formyl, acetyl, N-methylaminocarbonyl, N- phenylaminocarbonyl, N,N-dimethylaminocarbonyl, N- ethy1-N-phenylaminocarbonyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, hydroxyl, methoxy, ethoxy, propoxy, butoxy, isopropoxy, tert-butoxy, hydroxymethyl, trifluoromethoxy, amino, N-methylamino, N,N-dimethylamino, pyridyl, furyl, pyrazinyl, pyrrolyl, pyrazolyl, morpholino, pyrrolidinyl, piperazinyl, piperidinyl, triazolyl and nitro; or a pharmaceutically-acceptable salt thereof. 4. Compound of Claim 3 selected from compounds, and their pharmaceutically-acceptable salts or prodrugs, of the group consisting of 4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2- (4- pyridyl) thiazole; 2- (2-chlorophenyl) -4- (4-chlorophenyl) -5- (4- ethylsulfonylphenyl) thiazole; 2- (3-chloro-4-fluorophenyl) -4- (4-fluorophenyl) -5- (4- methylεulfonylphenyl) thiazole; 2- (2-chlorophenyl) -4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl) thiazole; 5- (4-fluorophenyl) -4- (4-methylsulfonylphenyl) -2- methylthiazole; 4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2- trifluoromethylthiazole; 4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2- (2- thienyl) thiazole; 4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2- benzylaminothiazole; 4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2- (1- propyla ino) thiazole; 2- [ (3 , 5-dichlorophenoxy)methyl) -4- (4-fluorophenyl) -5- [4- (methylsulfonyl)phenyl] thiazole; 2- (2-chlorophenyl) -4- (2-fluorophenyl) -5- (4- methylsulfonylphenyl) thiazole; 2- ( (3-chlorophenoxy) ethyl) -4- (4-fluorophenyl) -5- (4- methylεulfonylphenyl) thiazole; 4- (4-fluorophenyl) -5- [4- (methylsulfonyl)phenyl] -2- (2- ethyl-4-thiazolyl) thiazole; 4- (4-fluorophenyl) -2- [ (4-methoxyphenoxy) ethyl] -5- [4- (methylsulfonyl)phenyl] thiazole; 4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2- phenylthiazole; 4- (4-fluorophenyl) -2-n-hexylamino-5- (4- ethylεulfonylphenyl) thiazole; 2-butylamino-4- (4-fluorophenyl) -5- (4- methylεulfonylphenyl) thiazole; 4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2- methyla inothiazole; 4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2- (4- methoxyphenyl) thiazole; 2-ethylamino-4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl) -thiazole; 2-ter -butylamino-4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl) thiazole; 2- (3, 5-dichlorophenylamino) -4- (4-fluorophenyl) -5- (4- methylsulfonylphenyl) thiazole; 5- (4-fluorophenyl) -4- (4-methylsulfonylphenyl) -2- trifluoromethylthiazole; and 4- (4-fluorophenyl) -5- (4-methylsulfonylphenyl) -2- (2,3,4,5, 6-pentafluorophenyl) thiazole. 5. A compound of Formula II wherein R^ is selected from alkyl and amino; wherein R 5 is selected from aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R 5 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, aminosulfonyl, alkyl, alkenyl, alkynyl, cyano, carboxyl, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, acyl, N- alkylaminocarbonyl, N-arylaminocarbonyl, N,N- dialkylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, haloalkoxy, amino, N-alkylamino, N,N-dialkylamino, heterocyclic and nitro; and wherein R 6 is selected from halo, amino, alkoxy, nitro, hydroxyl, aminocarbonyl, acyl, alkylaminocarbonyl, arylammocarbonyl, alkenyl, alkynyl, haloalkoxy, alkylamino, arylamino, aralkylamino, alkoxycarbonylalkyl, alkylaminoalkyl, heterocycloalkyl, aralkyl, cyanoalkyl, N- alkylsulfonylamino, heteroarylsulfonylaikyl, heteroarylsulfonylhaloalkyl, aryloxyalkyl, aralkyloxyalkyl, aryl and heterocycio, wherein the aryl and heterocycio radicals are optionally substituted at a substitutable position with one or more radicals selected from halo, alkyl, alkoxy, alkylthio, alkylsulfinyl, haloalkyl, haloalkoxy, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, amino, acyl and alkylamino; or a pharmaceutically-acceptable salt thereof. 6. Compound of Claim 5 wherein R 4 is selected from lower alkyl and amino; wherein R 5 is selected from aryl, lower cycloalkyl, lower cycloalkenyl and heteroaryl; wherein R 5 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower haloalkylsulfonyl, aminosulfonyl, lower alkyl, lower alkenyl, lower alkynyl, cyano, carboxyl, lower carboxyalkyl, lower alkoxycarbonyl, aminocarbonyl, acyl, lower N-alkylaminocarbonyl, lower N- arylaminocarbonyl, lower N,N-dialkylaminocarbonyl, lower N-alkyl-N-arylaminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, amino, lower N-alkylamino, lower N,N- dialkylamino, heterocyclic and nitro; and wherein R 6 is selected from halo, amino, lower alkoxy, nitro, hydroxyl, aminocarbonyl, acyl, lower , alkylaminocarbonyl, lower arylaminocarbonyl, lower alkenyl, lower alkynyl, lower haloalkoxy, lower alkylamino, phenylamino, lower aralkylamino, lower alkoxycarbonylalkyl, lower alkylaminoalkyl, lower heterocycloalkyl, lower aralkyl, lower cyanoalkyl, lower N-alkylsulfonylamino, lower heteroarylsulfonylaikyl, lower heteroarylsulfonylhaloalkyl, lower aryloxyalkyl, lower aralkyloxyalkyl, phenyl optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower haloalkyl, lower haloalkoxy, lower carboxyalkyl, lower alkoxycarbonyl, aminocarbonyl, amino, acyl and lower alkylamino, and heterocyclic optionally εubεtituted at a εubstitutable position with one or more radicals selected from halo, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower haloalkyl, lower haloalkoxy, lower carboxyalkyl, lower alkoxycarbonyl, aminocarbonyl, amino, acyl and lower alkylamino; or a pharmaceutically-acceptable salt thereof. 7. A compound of Formula III R S0 2 III wherein R 4 is selected from alkyl and amino; wherein R 5 is selected from aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R 5 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, aminosulfonyl, alkyl, alkenyl, alkynyl, cyano, carboxyl, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, acyl, N- alkylaminocarbonyl, N-arylaminocarbonyl, N,N- dialkylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, haloalkoxy, amino, N-alkylamino, N,N-dialkylamino, heterocyclic and nitro; and wherein R 7 is selected from hydrido, alkyl, haloalkyl, cyano, hydroxyalkyl, alkoxyalkyl, carboxyl, carboxyalkyl, and alkoxycarbonyl; provided that R 5 is not 4-fluorophenyl when R 7 is methyl; further provided R 5 is not phenyl substituted with α,α-bis (methyl)methanol; and further provided that R 4 is not methyl when R 7 is α,α -bis (trifluoromethyl) ethanol; or a pharmaceutically- acceptable salt thereof. 8. Compound of Claim 7 wherein R 4 is selected from lower alkyl and amino; wherein R 5 is selected from aryl, lower cycloalkyl, lower cycloalkenyl and heteroaryl; wherein R 5 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower haloalkylsulfonyl, aminosulfonyl, lower alkyl, lower alkenyl, lower alkynyl, cyano, carboxyl, lower carboxyalkyl, lower alkoxycarbonyl, aminocarbonyl, acyl, lower N-alkylaminocarbonyl, lower N- arylaminocarbonyl, lower N,N-dialkylaminocarbonyl, lower N-alkyl-N-arylaminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower haloalkoxy, amino, lower N-alkylamino, lower N,N- dialkylamino, heterocyclic and nitro; and wherein R 7 is selected from hydrido, lower alkyl, lower haloalkyl, cyano, lower hydroxyalkyl, lower alkoxyalkyl, carboxyl, lower carboxyalkyl, and lower alkoxycarbonyl; or a pharmaceutically-acceptable salt thereof. 9 . A compound of Formula IV R 4 wherein R 1 is selected from hydrido, halo, amino, alkoxy, cyano, nitro, hydroxyl, aminocarbonyl, acyl, alkylaminocarbonyl, arylaminocarbonyl, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, alkylamino, arylamino, aralkylamino, carboxyl, carboxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkylaminoalkyl, heterocycloalkyl, aralkyl, hydroxyalkyl, alkoxyalkyl, cyanoalkyl, N-alkylsulfonylamino, heteroarylsulfonylaikyl, heteroarylsulfonylhaloalkyl, aryloxyalkyl, aralkyloxyalkyl, aryl and heterocycio, wherein the aryl and heterocycio radicals are optionally substituted at a substitutable position with one or more radicals selected from halo, alkyl, alkoxy, alkylthio, alkylsulfinyl, haloalkyl, haloalkoxy, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, amino, acyl and alkylamino; wherein R 4 is selected from alkyl and amino; and wherein R 8 is heterocyclic; wherein R 8 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkyl, alkenyl, alkynyl, cyano, carboxyl, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, acyl, N-alkylaminocarbonyl, N- arylaminocarbonyl, N,N-dialkylaminocarbonyl, N-alkyl- N-arylaminocarbonyl, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, haloalkoxy, amino, N-alkylamino, N,N- dialkylamino, and nitro; or a pharmaceutically-acceptable salt thereof. 10. Compound of Claim 9 wherein R 1 is selected from hydrido, halo, amino, lower alkoxy, cyano, nitro, hydroxyl, aminocarbonyl, acyl, lower alkylaminocarbonyl, phenylaminocarbonyl, lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, lower haloalkoxy, lower alkylamino, phenylamino, lower aralkylamino, carboxyl, lower carboxyalkyl, lower alkoxycarbonyl, lower alkoxycarbonylalkyl, lower alkylaminoalkyl, lower heterocycloalkyl, lower aralkyl, lower hydroxyalkyl, lower alkoxyalkyl, lower cyanoalkyl, lower N-alkylsulfonylamino, lower heteroarylsulfonylaikyl, lower heteroarylsulfonylhaloalkyl, lower aryloxyalkyl, aralkyloxyalkyl, aryl optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower haloalkyl, lower haloalkoxy, lower carboxyalkyl, lower alkoxycarbonyl, aminocarbonyl, amino, acyl and lower alkylamino, and heterocyclic optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower haloalkyl, lower haloalkoxy, lower carboxyalkyl, lower alkoxycarbonyl, aminocarbonyl, amino, acyl and lower alkylamino; wherein R 4 is selected from lower alkyl and amino; and wherein R 8 is nitrogen-containing heteroaryl optionally substituted at a substitutable position with one or more substituents independently selected from halo, alkyl, alkoxy, alkylthio, amino and alkylamino; or a pharmaceutically-acceptable salt thereof . 11. Compound of Claim 10 wherein R 1 is selected from hydrido, methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, tert-butyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, cyanomethyl, cyanoethyl, cyanopropyl, methylamino, ethylamino, propyla ino, butylamino, tert-butylamino, pentylamino, hexylamino, phenethyl, phenylpropyl, benzyl, phenylamino, thienylsulfonyImethyl, thienylsulfonylbromomethyl, benzyla ino, phenoxymethyl, 3, 5-dichlorophenylamino, 3,5- dichlorophenoxymethyl, 3-chlorophenoxymethyl, methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl, ter -butoxycarbonyl, propoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, pentoxycarbonyl, phenyl optionally substituted at a subεtitutable position with one or more radicals selected from fluoro, chloro, bromo, methoxy, ethoxy, propoxy, butoxy, isopropoxy and tert- butoxy, and a heterocyclic radical selected from thienyl, pyridyl, furyl, oxazolyl, pyrimidinyl, pyrazinyl, quinolyl, isoquinolinyl, imidazolyl, thiazolyl, pyrrolyl, pyrazolyl and triazolyl, optionally εubstituted at a substitutable position with one or more radicals selected from fluoro, chloro, bromo, methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl and tert-butyl; wherein R 4 is methyl or amino; and wherein R 8 is selected from pyridyl, thienyl, thiazolyl, oxazolyl, pyrimidinyl, pyrazinyl, quinolyl, isoquinolinyl, imidazolyl, and benzimidazolyl, wherein R 8 is optionally substituted at a substitutable position with one or more substituents independently selected from fluoro, chloro, bromo, methyl, ethyl, isopropyl, tert-butyl, isobutyl, methoxy, ethoxy, isopropoxy, ter -butoxy, propoxy, butoxy, isobutoxy, pentoxy, methylthio, amino, N-methylamino and N,N-dimethylamino; or a pharmaceutically-acceptable salt thereof. 12. A pharmaceutical composition comprising a therapeutically-effective amount of a compound, said compound selected from a family of compounds of Claim 1; or a pharmaceutically-acceptable salt thereof. 13. A pharmaceutical composition comprising a therapeutically-effective amount of a compound, said compound selected from a family of compounds of Claim 2; or a pharmaceutically-acceptable salt thereof. 14. A pharmaceutical composition comprising a therapeutically-effective amount of a compound, said compound selected from a family of compounds of Claim 3; or a pharmaceutically-acceptable salt thereof. 15. A pharmaceutical compoεition compriεing a therapeutically-effective amount of a compound, said compound selected from a family of compounds of Claim 4; or a pharmaceutically-acceptable salt thereof. 16. A pharmaceutical composition comprising a therapeutically-effective amount of a compound, said compound selected from a family of compounds of Claim 5; or a pharmaceutically-acceptable salt thereof. 17. A pharmaceutical composition comprising a therapeutically-effective amount of a compound, said compound selected from a family of compounds of Claim 6; or a pharmaceutically-acceptable salt thereof. 18. A pharmaceutical composition comprising a therapeutically-effective amount of a compound, said compound selected from a family of compounds of Claim 7; or a pharmaceutically-acceptable salt thereof. 19. A pharmaceutical composition comprising a therapeutically-effective amount of a compound, said compound selected from a family of compounds of Claim 8; or a pharmaceutically-acceptable salt thereof. 20. A pharmaceutical composition comprising a therapeutically-effective amount of a compound, said compound selected from a family of compounds of Claim 9; or a pharmaceutically-acceptable salt thereof. 21. A pharmaceutical composition comprising a therapeutically-effective amount of a compound, said compound selected from a family of compounds of Claim 10; or a pharmaceutically-acceptable salt thereof. 22. A pharmaceutical composition comprising a therapeutically-effective amount of a compound, said compound selected from a family of compounds of Claim 11; or a pharmaceutically-acceptable salt thereof. 23. A method of treating inflammation or an inflammation-associated disorder in a subject, said method comprising administering to the subject having or susceptible to said disorder, a therapeutically- effective amount of a compound of Claim 1; or a pharmaceutically-acceptable salt thereof. 24. A method of treating inflammation or an inflammation-associated disorder in a subject, said method comprising administering to the subject having or susceptible to said disorder, a therapeutically- effective amount of a compound of Claim 2; or a pharmaceutically-acceptable salt thereof. 25. A method of treating inflammation or an inflammation-associated disorder in a subject, said method comprising administering to the subject having or susceptible to said disorder, a therapeutically- effective amount of a compound of Claim 3; or a pharmaceutically-acceptable salt thereof. 26. A method of treating inflammation or an inflammation-associated disorder in a subject, said method comprising administering to the subject having or susceptible to said disorder, a therapeutically- effective amount of a compound of Claim 4; or a pharmaceutically-acceptable salt thereof. 27. A method of treating inflammation or an inflammation-associated disorder in a subject, said method comprising administering to the subject having or susceptible to said disorder, a therapeutically- effective amount of a compound of Claim 5; or a pharmaceutically-acceptable salt thereof. 28. A method of treating inflammation or an inflammation-associated disorder in a subject, said method comprising administering to the subject having or susceptible to said disorder, a therapeutically- effective amount of a compound of Claim 6; or a pharmaceutically-acceptable salt thereof. 29. A method of treating inflammation or an inflammation-associated disorder in a subject, said method comprising administering to the subject having or susceptible to said disorder, a therapeutically- effective amount of a compound of Claim 7; or a pharmaceutically-acceptable salt thereof. 30. A method of treating inflammation or an inflammation-associated disorder in a subject, said method comprising administering to the subject having or susceptible to said disorder, a therapeutically- effective amount of a compound of Claim 8; or a pharmaceutically-acceptable salt thereof. 31. A method of treating inflammation or an inflammation-associated disorder in a subject, said method comprising administering to the subject having or susceptible to said disorder, a therapeutically- effective amount of a compound of Claim 9; or a pharmaceutically-acceptable salt thereof. 32. A method of treating inflammation or an inflammation-associated disorder in a subject, said method comprising administering to the subject having or susceptible to said disorder, a therapeutically- effective amount of a compound of Claim 10; or a pharmaceutically-acceptable salt thereof. 33. A method of treating inflammation or an inflammation-associated disorder in a subject, said method comprising administering to the subject having or susceptible to said disorder, a therapeutically- effective amount of a compound of Claim 11; or a pharmaceutically-acceptable salt thereof. 34. The method of Claim 23 for use in treatment of inflammation. 35. The method of Claim 23 for use in treatment of an inflammation-associated disorder. 36. The method of Claim 35 wherein the inflammation-associated disorder is arthritis. 37. The method of Claim 35 wherein the inflammation-associated disorder is pain. 38. The method of Claim 35 wherein the inflammation-associated disorder is fever.

Inventors: CARTER JEFFERY S, COLLINS PAUL W, KRAMER STEVEN W, PENNING THOMAS D, ROGERS ROLAND S, ROGIER DONALD J JR, TALLEY JOHN J, CARTER, JEFFERY, S., COLLINS, PAUL, W., KRAMER, STEVEN, W., PENNING, THOMAS, D., ROGERS, ROLAND, S., ROGIER, DONALD, J., JR., TALLEY, JOHN, J.
Applicants: CARTER JEFFERY S, COLLINS PAUL W, KRAMER STEVEN W, PENNING THOMAS D, ROGERS ROLAND S, ROGIER DONALD J JR, SEARLE & CO, TALLEY JOHN J, CARTER, JEFFERY, S., COLLINS, PAUL, W., G.D. SEARLE & CO., KRAMER, STEVEN, W., PENNING, THOMAS, D., ROGERS, ROLAND, S., ROGIER, DONALD, J., JR., TALLEY, JOHN, J.
Application year: 1995
Main classification: C07D277
IPC codes: A61K31, A61P3, A61P29, C07D277, C07D417