Method and device for processing ECG-signals

Abstract: In a method for processing ECG-signals for the purpose of detecting low-amplitude signal structures in noise, the ECG-signals from a plurality of cardiac cycles are A/D-converted, and QRS complexes are detected. The signals from at least two cardiac cycles are time-synchronized, whereupon the concordance between these signals in intervals comprising at least two samples is determined, and an output quantity, representing the concordance thus determined, is generated, the magnitude of the output quantity designating the amplitude of the signal structure in question. A device for processing ECG-signals, in a similar manner, comprises means (24) for recording ECG-signals from a plurality of cardiac cycles, A/D-conversion of the signals and detection of QRS complexes. A synchronization unit is arranged to time-synchronize the signals from at least two cardiac cycles, and a calculator unit (10) is arranged to determine the concordance between the signals in time intervals, comprising at least two samples. The output means (12) are, finally, connected to the calculator unit in order to generate an output quantity the magnitude of which designates the amplitude of the signal structures in question.

Description: The present invention relates to a method and a device for processing ECG-signals for the purpose of detecting low-amplitude signal structures in noise of the kind described in the preambles of claims 1 and 13 respectively. These signal structures, such as so-called late potentials, have an amplitude of the order of a few µV, usually making impossible direct, quantitative detection of the same in the ECG-signal. Signal averaging has hitherto been frequently used to reduce the level of noise. The signal is further subjected to highpass filtration in order to eliminate low-frequency components. The vector quantities of the X, Y and Z leads is then compared to a threshold value so as to determine whether or not late potentials are present, cf. US,A,4 422 459. However, residual noise affects the vector quantity, thereby degrading accuracy. Important information in individual leads is also lost when they are combined into a single vector quantity. Spectral analysis of late potentials has also appeared to be associated with major difficulties, since spectral analysis of predominantly transient signals is generally complicated. The object of the present invention is to propose a new method and provide a new device, based on a statistical model which explicitly takes the presence of noise into account, for more reliable detection of low-amplitude signal structures in ECG-signals. This object is achieved with a method and a device of the kind mentioned in the introductory part having the characterizing features set forth in claims 1 and 13 respectively. The present invention utilizes the circumstance that noise is essentially uncorrelated from one cardiac cycle to another, whereas the ECG-activity of interest is repetitive. According to one advantageous further development of the invention, at least two sub-average values are formed of at least the part of the signals containing the signal structure in question from at least two different groups of cardiac cycles in the plurality of cardiac cycles, whereupon the concordance between the sub-average values is determined. This improves the possibility of separating the signal from noise. In the present invention each lead is processed individually, thereby avoiding the loss of information which occurs when a plurality of leads is combined into a single vector unit. The invention will now be described in greater detail with the aid of an exemplifying embodiment of the device according to the invention with reference to the attached drawings in which FIG. 1 is an overview block diagram of the device according to the invention; FIG. 2 is a block diagram of the unit for identifying low-amplitude signals in the presence of noise, and FIG. 3 illustrates, also in the form of a block diagram, in greater detail so-called eigenvector filtration and subsequent non-linear signal processing in order to provide a function suitable for determining the end time of late potentials. The recorded ECG-signals are converted into digital form in the A/D converter 2, and the QRS complexes are detected in the detector 4 in FIG. 1. In the averager 6 are formed at least two sub-average values of the signals, and in the unit 8 is set an interval or a time window which is utilized in the subsequent unit 10 for determining the possible presence of a signal in the noise environment. The unit 10 comprises a calculator unit for calculating the cross-covariance of the sub-average values received from the averager 6 in successive, overlapping time intervals set in the unit 8. These calculations result in a cross-covariance matrix which determines the eigenvectors utilized for eigenvector-based filtration of the sub-average values for the purpose of filtering signals out of the noise. This is described in greater detail below. After the unit 10 follows an additional means 12 for non-linear processing of the accordingly filtered signals, so an output signal is achieved which essentially represents the signal amplitude. The end time of the signal is finally determined in the unit 14 from the chronological course of the signal amplitude curve obtained. The unit 14 comprises a comparator unit which compares the terminal part of the signal amplitude curve with a predetermined standard curve which is successively displaced in relation to the signal amplitude curve so the time at which the concordance between the standard curve and the signal amplitude curve is best can be determined, which time is set as the end time for the late potentials. In FIG. 2 the construction of the units 6, 8, 10, 12 in FIG. 1 is described in greater detail. After time-synchronization of the signals from individual cardiac cycles, the signals are processed in the signal processing unit 16, e.g. high-pass filtered to remove low-frequency components. In the unit 18, an estimate is made of the noise a in the signals from the unit 16, and this noise estimate is supplied to the unit 20. The processed signals are also supplied to an averager 24, to form at least two sub-average values, as above, and then to a calculator unit 26 for calculation of the cross-covariance between the sub-average values. The cross-covariance calculations result in a cross-covariance matrix the eigenvectors e i and eigenvalue λ i of which as well as the sub-average values obtained from the averager 24, are supplied to the unit 20. The signals are supplied to the averager 24 in the form of an ensemble of time-synchronized signals from a plurality of cardiac cycles. One sub-average value is formed by calculation in successive, overlapping intervals or time windows of every other signal in the ensemble, and the other sub-average value is formed by corresponding calculation of the intermediate signals in the ensemble. Every time window is long enough to cover at least two samples. However, this is only one example of the way in which averaging can be performed. It can obviously be carried out in countless different ways. Thus, too differing signals in the signal ensemble could e.g. be excluded in determination of average values, and the determination of average values need not be performed in successive, overlapping intervals, as mentioned in the example above. Averaging does not have to be performed using every other signal of the ensemble, but the signals in the ensemble could be divided into two groups in some other way, whereupon average values could be formed of the signals in the groups. The unit 20 in FIG. 2 is shown in greater detail in FIG. 3. At 28 in FIG. 3, the eigenvectors of the cross-covariance matrix e 1 , e 2 ... e 2M are used for eigenvector-based filtration of the sub-average values. Filtering the sub-average values with the most significant eigenvectors, or even only the most significant eigenvector, i.e. the vector or vectors corresponding to the largest eigenvalues, is often sufficient. In practice, therefore, filtration with a limited number of eigenvectors is enough. After the filtration the signals are supplied to the squarer 30 which delivers output signals corresponding to the quantities t 1 2 , t 2 2 ... t 2M 2 where t i denotes the correlation between the subaverage values and the i:th eigenvector. The outputs of the squarer 30 are connected to a so-called Maximum Likelihood estimator 32 to which the noise variance σ 2 , and the eigenvalues from the cross-covariance matrix are fed from the unit 18 for noise estimation and from the unit 26 for calculating the cross-covariance in FIG. 2 respectively. The signal effect Θ 2 is determined in the estimator 32 by solving the equation in which λ i designates eigenvalues of the cross-covariance matrix, σ v 2 the variance of the estimated noise, t i the correlation between the sub-average values and the i-th column in the eigenvector matrix Θ 2 the signal effect, and m the number of samples in the interval. Since Θ 2 is not always greater than zeros, Θ 2 is supplied to a unit 34 with diode-like characteristic which gives an output signal which is equal to zero for negative Θ 2 -values and an output signal directly proportional to Θ 2 for positive Θ 2 -values, whereupon the square root of this quantity is calculated in the unit 36. The output signal for the unit 36 represents the signal amplitude Θ. Thus, the present invention makes possible very effective detection of low-amplitude ECG-activity in a noise environment, correlation in both time and over an ensemble of cardiac cycles being taken into account.

Claims: Method for processing ECG-signals for the purpose of detecting low-amplitude signal structures in noise, in which method ECG-signals from a plurality of cardiac cycles are A/D converted, and QRS complexes are detected, characterized in that the signals from at least two cardiac cycles are timesynchronized, whereupon the concordance between these signals in time intervals encompassing at least two samples is determined, and an output quantity representing the concordance thus determined is generated, the magnitude of the output quantity designating the amplitude of the signal structures in question. Method according to claim 1, characterized in that the noise level is estimated of the signals from each heart cycle for compensation at the determination of the concordance. Method according to any of claims 1 or 2, characterized in that at least two sub-average values are formed of at least the part of the signals containing the signal structure in question from at least two different groups of cardiac cycles in said plurality of cardiac cycles, whereupon the concordance between the sub-average values is determined. Method according to claim 3, characterized in that n sub-average values, where n>2, are determined from the signals of the cardiac cycles 1, n+1, 2n+1 ... and 2, n+2, 2n+2 etc. and n; 2n, 3n ... respectively of the said plurality of cardiac cycles. Method according to any of claims 3 or 4, characterized in that the cross-covariance of the sub-average values is determined in order to determine the concordance between these values. Method according to claim 5, characterized in that the cross-covariance is calculated for the sub-average values in successive, overlapping intervals. Method according to any of claims 5 or 6, characterized in that the sub-average values are filtered according to the magnitude of cross-covariance, whereupon the filtered values are subjected to non-linear processing to form a function representing the amplitude of said signal structures. Method according to claim 7, characterized in that the noise compensation of the filtered sub-average values is performed in conjunction with the non-linear signal processing. Method according to any of claims 5 - 8, characterized in that the concordance of the sub-average values is represented by a cross-covariance matrix resulting from the calculation of cross-covariance, and in that the filtration of the sub-average values is performed as an eigenvector-based filtration with eigenvectors determined from the cross-covariance matrix. Method according to any of claims 7 - 9, characterized in that the non-linear processing comprises squaring of the filtered sub-average values, calculation of the signal power and calculation therefrom of the signal amplitude. Method according to claim 10, characterized in that the resulting signal amplitude curve is compared with a standard curve for determining a characteristic time in the signal structure in question, e.g. its end point. Method according to any of claims 1 - 11, characterized in that the said signal structures comprise so-called late potentials. Device for processing ECG-signals for the purpose of detecting low-amplitude signal structures in noise, comprising means (2,4) for recording ECG-signals from a plurality of cardiac cycles, A/D-conversion of the signals and detection of QRS complexes, characterized in that a synchronization unit is arranged to time-synchronize the signals from at least two cardiac cycles, and in that a calculator unit (10) is arranged to determine the concordance between the signals in time intervals, comprising at least two samples, and in that output means (12) are connected to the calculator unit in order to generate an output quantity the magnitude of which designates the amplitude of the signal structures in question. Device according to claim 13, characterized in that an averager (6) is arranged to form at least two sub-average values of at least the parts of the ECG-signals, which comprise said signal structures, in at least two different groups of cardiac cycles of said plurality of heart cycles, said averager (6) being connected to the calculator unit (10) for determining the concordance between the sub-average values. Device according to claim 14, characterized in that the calculator unit (10) is arranged to form the cross--covariance between the sub-average values in order to determine the concordance. Device according to claim 15, characterized in that the calculator unit (10) is connected to a filter unit (16) for filtering the sub-average values according to the magnitude of cross-covariance, and in that a signal processing unit (12) is arranged to subject the filtered values to a non-linear processing in order to form a function representing the amplitude of said signal structures. Device according to claim 16, characterized in that a unit (18) is arranged to estimate the level of noise in the signal from each cardiac cycle, which unit is connected to the signal processing unit (10) in order to compensate the sub-average values for the noise in conjunction with the non-linear signal processing. Device according to any of claims 15 - 17, characterized in that the calculator unit (10) is arranged to calculate the cross-covariance of the sub-average values in successive, overlapping intervals. Device according to any of claims 16 - 18, characterized in that the calculator unit (10) controls the filter unit (16) to perform eigenvector-based filtration, controlled by eigenvectors determined by the cross-covariance calculation. Device according to any of claims 16 - 19, characterized in that the signal processing unit (12) is arranged to square the filtered sub-average values and determine the signal power and therefrom the signal amplitude. Device according to patent claim 20, characterized in that the signal processing unit (12) comprises a so-called Maximum Likelihood estimator (32), arranged to solve the Maximum Likelihood equation in which λ i denotes eigenvalues of the cross-covariance matrix, σ v 2 the variance of the estimated noise, t i the correlation between sub-average values and i:th column in the eigenvector matrix, Θ 2 the signal power, and m the number of samples in the interval. Device according to any of the claims 16 - 21, characterized in that a comparator unit (14) is connected to the output of the signal processing unit (12) in order to compare the terminal part of the signal amplitude curve with a predetermined standard curve in order to determine a characteristic time in the signal structure as the time position in the standard curve which gives the best concordance with the signal amplitude curve.

Inventors: ATARIUS ROOZBEH, OHLSSON THOMAS, SOERNMO LEIF, ATARIUS, ROOZBEH, OHLSSON, THOMAS, SOERNMO, LEIF, Sörnmo, Leif
Applicants: SIEMENS ELEMA AB, SIEMENS-ELEMA AB
Application year: 1994
Main classification: G06F17
IPC codes: G06F17, A61B5