3-SUBSTITUTED 1-ARYLINDOLE COMPOUNDS

Abstract: 3-Substituted 1-arylindole compound having general formula (I) wherein Ar is an optionally substituted aryl group; X represents a bond, a divalent hydrocarbon group or methyleneoxy or -thioxo; R<1>-R<2> are hydrogen or substituents; R<5> is hydrogen, hydroxy, alkoxy, halogen, trifluoromethyl, alkyl or alkenyl; R<6> and R<7> are hydrogen, alkyl or alkenyl; R<8> is alkyl or alkenyl or represents a group of formula (1a) or (1b); wherein: W is O or S; U is N or CH; Z is (CH2)m, 1,2-phenylene, CH=CH, COCH2 or CSCH2-; V is O, S, CH2, or NR<10>, wherein R<10> is hydrogen or alkyl; U<1> is O, S, CH2 or NR<11>, wherein R<11> is as R<10>; and V<1> is NR<12>R<13>, OR<14>, SR<15> or CR<16>R<17>R<18>, where each of R<12>-R<18> are as the R<10>-substituents; R<9> is hydrogen or alkyl; or R<9> is linked to R<7> to form a ring; or R<8> and R<9> together form a morpholinyl or piperidinyl ring, the latter optionally substitued by alkyl or a group of formula (1a) or (1b), or a carbamoyl group, show central antiserotonergic activity and possibly also antidopaminergic activity and are, accordingly, useful in the treatment of central nervous system (CNS) disorders. The compounds are prepared by methods known per se.

Description: 3-Substituted 1-Arylindole Compounds Field of the Invention The present invention relates to novel 3-substituted 1-arylindole compounds and their acid addition salts, to methods for preparing such compounds, pharmaceutical compositions comprising the compounds as an active ingredient and to their use. The novel compounds show central antiserotonergic activity and possibly also antidopaminergic activity and are, accordingly, useful in the treatment of central nervous system (CNS) disorders. Background of the Invention It is well known that serotonin (5-HT) receptor antagonists, in particular 5-HT 2 recep¬ tor antagonists, are useful in the treatment of CNS disorders. So, 5-HT 2 receptor antagonists have been reported to show effects in the treatment of anxiety, agression, depression, sleep disturbances, migraine, negative symptoms of schi¬ zophrenia, extrapyramidal side effects induced by conventional antipsychotics, abuse of drugs and substances of abuse and Parkinson ' s disease. For example reference may be made to the following: The selective 5-HT 2 receptor antagonist ritanserin has been shown to be an anti- depressant and to improve depressive symptoms of schizophrenia (E. Klieser, W. H. Strauss; Pharmacopsychiat. 21 (1988), pp. 391-393) and it has been demonstra¬ ted to exert effects in an animal test indicative of anxiolytic drug activity (F.C. Colpart et al.; Psychopharmacology (1985) 86; 303-305). Furthermore, ritanserin has been shown to improve the quality of sleep (P. A. J. Janssen; Pharmacopsy¬ chiat. 21 (1988), 33-37). It is generally believed that 5-HT is involved in migraine attacks. The links between 5-HT and migraine attacks are several and they suggest a number of mechanisms whereby 5-HT may be involved (Scrip Report; "Migraine - Current trends in research and treatment"; PJB Publications Ltd.; May 1991). Studies of the mixed serotonin and dopamine receptor antagonist setoperone indi- cate that blockade of 5-HT 2 receptors may be related to improvement of negative symptoms of schizophrenia (Ceulemans et al., Psychopharmacology (1985) 85, 329-332). Finally, ritanserin has been found to relieve neuroleptic-induced parkinsonism (Bersani et al.; Clinical Neuropharmacology, 13, No. 6 (1990), 500-506) and to reduce abuse of alcohol and drugs (Meert et al.., Pharmacopsychiatry, 24 (5), 1991 , 159-163). Damping of dopamine (DA) overactivity by the use of DA receptor blocking drugs is today the most important principle in the treatment of schizophrenia, in particular the positive symptoms thereof. "Classical neuroleptics" such as haloperidol, cis-(Z)- flupentixol and chlorpromazine are believed to induce antipsychotic effect via DA receptor blockade. U.S. Patent No. 4,710,500, corresponding to European Patent No. 0200322, disclo¬ ses a class of optionally 5-substituted 1 -aryl-3-piperidinyl, 1-aryl-3-( 1 ,2,3, 6-tetra- hydropyridinyl)- or 1-aryl-3-piperazinylindole derivatives having potent 5-HT 2 anta¬ gonistic activity, and many of them additionally having potent dopamine D 2 - antagonistic activity in vivo . European Patent Application No. 916010055.5 published as EP-A2-0465398 disclo¬ ses a class of 6-substituted and/or 2-alkyl substituted indole and 2,3-dihydroindole derivatives having antiserotonergic activity. It is the object of the present invention to provide new compounds having antiseroto¬ nergic, in particular 5-HT 2 antagonistic activity, and possibly also antidopaminergic activity. Summary of the invention It has now been found that compounds of a novel class of 3-substituted 1-arylindole compounds possess central antiserotonergic activity and some of them additionally antidopaminergic activity. Accordingly, the present invention relates to novel compounds of general Formula I wherein Ar is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2- furyl, 3-furyl, 2-pyridyl, 3-pyridyl, and 4-pyridyl, and such groups substituted with one or more substituents selected from halogen, lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and cyano; X represents a bond or a divalent spacer selected from the group consisting of A-CR a R b and CR°R d , wherein A is O, S or CR e R f , and R a to R f are hydrogen, lower alkyl or lower alkenyl; the dotted line designates an optional bond; R 1 -R 4 are independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, nitro, lower alkylthio, lower alkylsulfonyl, lower alkyl- or dialkyiamino, cyano, trifluoromethyl, trifluoromethylsulfonyloxy and trifluoro- methylthio; R 5 is hydrogen, hydroxy, lower alkoxy, halogen, trifluoromethyl, lower alkyl optio¬ nally substituted with hydroxy or lower alkenyl optionally substituted with hydroxy; R 6 and R 7 independently represent hydrogen, lower alkyl or lower alkenyl; R 8 is lower alkyl, lower alkenyl or lower alkyl or lower alkenyl substituted with one or two hydroxy groups, or R 8 represents a group of Formula 1a or 1b : -(CH 2 ) n -U. ~ (CH2)n— IT i — C— V 1 i C W 1 b. w ιa. wherein n is an integer from 2 - 8; W is O or S; U is N or CH ; Z is (CH 2 ) m . rn being 2 or 3, 1 ,2-phenylene optionally substituted with halogen or trifluoromethyl, CH=CH, COCH 2 or CSCH2-; V is O, S, CH 2 , or NR 10 , wherein R 10 is hydrogen or lower alkyl, lower alkenyl, cyclo- alkyl or cycloalkyl-lower alkyl, each optionally substituted with one or two hydroxy groups; U 1 is O, S, CH2 or a group NR 11 , wherein R 11 is selected among the R 1 ^substitu¬ ents; and V 1 is NR 12 R 13 , OR 14 , SR 15 or CR 16 R 17 R 18 , where each of R 12 -R 18 may be indepen¬ dently selected among the R 10 -substituents; R 9 is hydrogen, lower alkyl, lower alkenyl or lower alkynyl; or R 9 is linked to R 7 in order to form a 5-6 membered ring containing one nitrogen atom; or R 8 and R 9 together with the nitrogen atom to which they are attached form a group of Formula 1c (CH 2 ) m / \ N Y wherein m is 1 or 2, Y is O, S or a group CH-R 19 where R 19 is hydrogen, or lower al¬ kyl or lower alkenyl, optionally substituted with one or two hydroxy groups; a group of Formula 1 a or 1 b as defined above; or a group CONR 20 R 21 , where R 20 and R 21 are hydrogen or lower alkyl, provided that Y may not be O or S when m is 1 ; and pharmaceutically acceptable salts thereof. In another aspect the invention relates to a method for the preparation of the novel compounds of Formula I. In yet another aspect the invention relates to a pharmaceutical composition comprising a novel compound of Formula I together with a suitable pharmaceuti¬ cally acceptable carrier or diluent. In yet another aspect the invention relates to the use of a compound of Formula I for preparing a pharmaceutical composition for treatment of anxiety, agression, depression, sleep disturbances, migraine, negative symptoms of schizophrenia, psychoses, extrapyramidal side effects induced by conventional antipsychotics, abuse of drugs and substances of abuse or Parkinson ' s disease. As already mentioned the present compounds show central 5-HT receptor antago- nistic activity, in particular 5-HT 2 receptor antagonistic activity, and additionally, many of the compounds show antidopaminergic activity and, accordingly, they are useful in the treatment of CNS disorders, i.e. the above listed disorders. Detailed Description of the invention Some of the compounds of general Formula I may exist as optical isomers thereof and such optical isomers are also embraced by the invention. In general Formula I, the term lower alkyl is intended to mean a Ci-Cβ straight chain or branched alkyl group such as methyl, ethyl, 1 -propyl, 2-propyl, 1 -butyl, 2- butyl, 2-methyl-2-propyl etc. Similarly, lower alkenyl and lower alkynyl designate C 2 -C 6 straight chain or branched alkenyl or alkynyl groups. Lower alkoxy, lower alkylthio, lower alkylsulfonyl, lower alkylamino and lower dialkyiamino similarly designate such groups wherein the alkyl moiety is a lower alkyl group as defined above. Cycloalkyl designates such a group having 3-7 carbon atoms and halogen means fluoro, chloro, bromo or iodo. The Z groups COCH 2 and CSCH 2 may be incorporated in the ring of Formula 1a in both directions. The term "indicate an optional bond" is intended to mean that the dotted line may or may not represent a bond, i.e. that the compounds of Formula I are indoles or indolines. The pharmaceutically acceptable acid addition salts of the compounds used in the invention are salts formed with non-toxic organic or inorganic acids. Exemplary of such organic salts are those with maleic, fumaric, benzoic, ascorbic, embonic, succinic, oxalic, bis-methylenesalicylic, methanesulfonic, ethanedisulfonic, acetic, propionic, tartaric, salicylic, citric, gluconic, lactic, malic, mandelic, cinnamic, citraconic, aspartic, stearic, palmitic, itaconic, glycolic, p-amino-benzoic, glutamic, benzene sulfonic and theophylline acetic acids, as well as the 8-halotheophyllines, for example 8-bromo-theophylline. Exemplary of such inorganic salts are those with hydrochloric, hydrobromic, sulfuric, sulfamic, phosphoric and nitric acids. In Formula I, Ar is preferably phenyl optionally substituted with halogen, most preferably 4-fluorophenyl. X is preferably a bond, CR c R d , 0-CR a R b or CR e R f -CR a R b in particular CR c R d , 0-CR a R b or CR e R f -CR a R b , R a to R f preferably all being hydrogen, and especially 0-CR a R b , wherein R a and R b each represent hydrogen. The dotted line preferably designate a bond. Preferably R 1 and R 4 are hydrogen, R 2 and R 3 are hydrogen, cyano or halogen, especially hydrogen bromo or chloro, R 5 is hydrogen or lower alkyl, optionally sub¬ stituted with hydroxy, and R 6 is hydrogen or lower alkyl. R 7 is preferably hydrogen or lower alkyl, most preferably hydrogen or methyl, or R 7 is linked to R 9 in order to form a 5-6 membered ring. R 8 is preferably lower alkyl or a group of Formula 1a wherein n is 2, 3 or 4; W is O; U is N; V is NR 10 , wherein R 10 is hydrogen, lower alkyl or lower alkenyl; and R 9 is hydrogen, lower alkyl or lower alkenyl; or R 9 is linked to R 7 in order to form a 5- or 6-membered ring, in particular a 5-membered ring, containing one nitrogen atom; or R 8 and R 9 together with the nitrogen atom to which they are attached form a group of Formula 1c wherein Y is O or a group CH-R 19 where R 19 is hydrogen or lower alkyl, or a group of Formula 1a as defined in the preceeding paragraph, or a group CONR 20 R 21 , where R 20 and R 21 are hydrogen or lower alkyl. In a preferred subgroup of the compounds of the invention, X is 0-CH 2 , CH 2 -CH 2 , CH 2 or a bond, in particular O-CH 2 , CH 2 -CH 2 or CH 2 ; R and R 4 are both hydrogen; R 2 is selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, nitro, lower alkylthio, lower alkylsulfonyl, lower alkyl- or dialkyi¬ amino, cyano, trifluoromethyl, trifluoromethylsulfonyloxy and trifluoromethylthio; R 3 is hydrogen, or alternatively R 3 is selected from the R 2 substituents; Ar is phenyl optionally substituted with halogen, in particular 4-fluorophenyl; R 6 and R 7 are both hydrogen; R 8 is a group of Formula 1a wherein n is 2, 3 or 4, in particular 2 or 3; W is O; U is N; V is NR 10 , wherein R 10 is hydrogen or lower alkyl, in particular hydrogen; and R 9 is lower alkyl in particular methyl. According to the invention the novel compounds of Formula I are prepared by a method comprising: a) Alkylating an amine of the formula HNR 8 R 9 , wherein the substituents R 8 and R 9 are defined as described above except that R 9 may not be linked to R 7 , with a compound of the following formula: wherein R 1 - R 7 , X, Ar and the dotted line are as defined above, except that R 7 may not be a part of a ring, and the group L is a leaving group, such as a halogen atom or a tosyl or a mesyl group; b) Reducing a compound of the following formula: wherein R 1 - R 8 , X, Ar and the dotted line are as defined above, except that R 8 and R 9 may not together with the nitrogen atom form a group of Formula 1c, and R x is an alkoxy or a lower alkyl group; c) Alkylating a compound of the following formula: wherein R 1 - R 7 , R 9 , X, Ar and the dotted line are as defined above, except that R 8 and R 9 may not together with the nitrogen atom form a group of Formula 1c, with an alkylating agent R 8 L in which R 8 is as defined above except that it may not be part of a ring, and L is a leaving group as defined above; d) Reducing a compound of the following formula: wherein R .1 1 - n R4 , n R8 , Γ RJ9 , X and Ar are as defined above, except that R a may not be linked to R 7 , and R γ is a lower alkyl group; e) Reducing a compound of the following formula: wherein R 1 - R 4 , R 6 - R 9 , X and Ar are as defined above and B is hydroxy or a halogen atom; f) acylating an aminoalkyl derivative of the following formula : wherein R 1 - R 7 ,R 9 , X, Y, Ar, R 11 , n and the dotted line are as defined above, except that R 8 and R 9 may not together with the nitrogen atom form a group of Formula 1c, with an acylating agent such as a carboxylic acid halogenide, anhydride or mixed anhydride, or a carbamoyi or thiocarbamoyi chloride, an isocyanate, isothiocyan- ate, or a substituted chloroformate; g) Reacting a 1 -unsubstituted indole derivative of the following formula: wherein R 1 -R 9 , X and the dotted line are as defined above, with an arylhalogenide, ArHal wherein Ar is as previously defined and Hal is iodine, bromine or chlorine; h) Reacting bromo-indole derivative of the following formula: wherein one of the substituents R 1 -R 4 is a bromine atom and the other substituents R 1 -R 4 are as defined above and Ar, R 5 -R 9 , X and the dotted line are as defined above, with copper cyanide; i) Reacting an indole derivative of the following formula: X wherein R 1 -R 5 and the dotted line are as described above, with a reducing agent and an amine of formula HNR 8 R 9 wherein R 8 and R 9 are defined as defined above. In method (a) the alkylation is performed at 20-120 °C in an aprotic solvent such as 5 acetone or isobutyl methyl ketone in the presence of free base (e.g. K2CO3 or tri- ethylamine). The starting material II is prepared from the corresponding alcohol, which is prepared as described below, either by reaction with mesylchloride or tosyl- chloride or by reaction with thionylchloride or phosphorus oxychloride at conditions obvious to the chemist skilled in the art. The amines used as reactants are either 10 commercially available or prepared by reaction of 1 -(2-chloroethyl)-2-imidazo- lidinone or 1-(2-chloroethyl)-3-(2-propyl)-2-imidazolidinone with excess of appropri¬ ate amines at standard conditions. The 3-(1-aryl-3-1 - -indolyl)propanols used as starting material for the preparation of 15 II are prepared as follows (EXAMPLE 1 ). Uilmann arylation of substituted 3-(3-1 H- indolyl)propanoic acids (prepared according to the metods described in GB Patent No. 1 , 220,628, Chem. Abstr. 1971 , 75, 5690h, Rensonβυll. Soc. Chim. Belg. 1959, 68, 258-269 and Salituroef al., J. Med. Chem. 1990, 33, 2944-2946) with properly substituted aryliodides in NMP, DMF, HMPA or DMSO with potasium carbonate as 20 base and catalyzed by copper, copper(l) iodide or copper(l) bromide at 150-200 °C results in substituted 3-(1 -aryl-3-1 H-indolyl)propanoic acids. The acids thus obtained are reduced to substituted 3-(1 -aryl-3-1 - -indolyl)propanols by lithium aluminum hydride reduction at standard conditions. 25 The substitued 2-(1 -aryl-3-1 H-indolyloxy)ethanols used as starting materials for the preparation of II are prepared as follows (EXAMPLE 2). Alkylation of substituted methyl 1 -aryl-3-hydroxy-1 - -indol-2-carboxylates (prepared from properly substitu¬ ted Λ/-(o-carboxyaryl)glycine according to methods described in Unangst et al., J. Heterocyclic Chem. 1984, 21 , 709-714 and J. Heterocyclic Chem. 1987, 24, 30 81 1-815) with methyl bromoacetate results in corresponding methyl 2-(2-methoxy- carbonyl-1-aryl-3-1 -/-indolyloxy)acetates, according to literature methods in Unangst et al., J. Heterocyclic Chem. 1984, 21, 709-714. These diesters are hydro- lyzed and subsequently decarboxylated to give corresponding 2-(1 -aryl-3-1 /- - indolyloxy)acetic acids by methods obvious to the chemist skilled in the art. The acids thus obtained are reduced to substituted 2-(1-aryl)-3-1 -'-indolyloxy]ethanols by lithium aluminum hydride reduction at standard conditions. The 2-(3-1 H-indolylthioJethanols used as starting materials for the preparation of II are prepared as follows. 2,3-Dihydro-1-aryl-3-1 /--indolones are reacted with 2-mer- captoacetic acid by heating of the reactants at reflux in toluene using a Dean-Stark apparatus with p-toluenesulfonic acid as a catalyst. (EXAMPLE 10). The acids thus formed are subsequently reduced to the corresponding alcohols by lithium alumi- nium hydride reduction at standard conditions. The substituted 2,3-dihydro-1-aryl-3- 1 H-indolones used as starting materials are prepared by deprotection of substituted 3-acetoxy-1-arylindoles (prepared according to methods in Perregaard et al., J. Med. Chem. 1992, 35, 1092-1101) by heating in an aqueous solution of sodium sulfite (EXAMPLE 4), according to the procedure described in Nenitzescu et al., Chem. Ber. 1958, 91, 1141-1145. In method (b) the reductions of III are performed by using LiAIH 4 , AIH 3 , B 2 H 6 or a BH 3 complex in an inert solvent as e.g. diethyl ether or tetrahydrofurane at 0 °C to 70 °C. The starting material III is prepared as described below. The carbamate proteceted or acylated compounds of Formula III in which R 8 is as defined above or is a hydrogen atom are prepared by reaction of a substituted 2,3- dihydro-1-aryl-3- 7H-indolone with a properly substituted amino alcohol by heating the reactants at reflux in toluene using a Dean-Stark apparatus and p-toluenesulf- onic acid as a catalyst (EXAMPLE 5). Compounds of Formula HI in which R 8 is a hydrogen atom are converted to compounds of Formula III in which R 8 is as defin¬ ed above by reducing the acyl or carbamate group to an alkyl group and subse¬ quently introduce appropriate carbamate or acyl groups by conventional methods. The substituted 2,3-dihydro-1-aryl-3- 7H-indolones used as starting materials are prepared as described above. The substituted aminoalcohols used as reactants are prepared according to literature procedures for corresponding compounds. The carbamate protected or acylated β-amino alcohols containing a chiral center are prepared from corresponding chiral α-amino acids according to a one-pot procedure desribed by Correa et al., Synth. Comm. 1991 , 21, 1-9. 2,2-Dimethyl-2-aminothanol is commercially available and was carbamate protected by standard procedures. The alkylation in method (c) is performed at 20-120 °C in an aprotic solvent such as acetone or isobutyl methyl ketone in the presence of a base (e.g. K 2 CO 3 or triethyl- amine) and the starting material IV is prepared as described below. The secondary amine IV is prepared by hydrolysis of a compound of Formula III using standard conditions for deprotection of carbamates or hydrolysis of tertiary amides obvious to the chemist skilled in the art or by reduction of compounds of Formula III in which R 8 is a hydrogen atom by conventional methods. In methods (d) and (e) the reductions of V and VI are performed by using UAIH 4 , AIH 3 , B 2 H 6 or a BH 3 complex in inert solvents as e.g. diethyl ether or tetrahydro- furane at 0 °C to 70 °C. The starting material is prepared by alkylation of substituted methyl 1-aryl-3-hydroxy-1 H-indol-2-carboxylates, prepared as described above, with N,Λ/-dimethyl-2-chloroacetamide according to the method described by Unangst et al.,J. Heterocyclic Chem. 1987, 24, 811-815. The starting material for method (e) is prepared by reaction of compound IV with an alkyl or aryl sulfo- nylchloride in an aprotic solvent such as e.g. dichloromethane at -30 °C to 0 °C. Aminoalkyl derivatives of the Formula VII used in method (f) are prepared by alkyla¬ ting a compound of the Formula IV with a halo-nitrile of the following formula: hal(CH 2 ) n -ιCN in the presence of a base (e.g. K 2 CO 3 or triethylamine) in an inert solvent such as acetone, MIBK or toluene at elevated temperature (30-100 °C). The cyano group may be reduced according to standard procedures using e.g. AIH 3 , UAIH 4 or B 2 H 6 . The R 1 1 substituent is introduced by direct alkylation or by an acylation/reduction procedure, which is obvious to the chemist skilled in the art. Acylation of the thus obtained amino derivatives is accomplished by addition of an acylating agent at a low temperature (-20 to 30 °C) preferably in a chlorinated solvent (dichloromethane, chloroform, or 1 ,1 ,1-trichloroethane) and, if necessary, in the presence of a base to neutralize any acidic reaction product formed. In method g) the Ullman arylation is conveniently performed as described above for the arylation of 3-(3-1 /--indolyl)propanoic acid (EXAMPLE 13). The starting material Vm in which X is a methylene group is prepared by acylation of the corresponding 1 ,3-unsubstituted indole with oxalyl chloride which subsequently is reacted with appropriate amines HNR 8 R 9 . The glyoxamide formed is reduced to the correspond¬ ing tryptamine by treatment with lithium aluminum hydride according to literature methods (EXAMPLE 14) (Welstad et al. J. Med. Chem. 1967, 10, 1015- 1021). In method h) the Rosenmund-von Braun reaction is performed with copper cyanide in NMP, DMF or MSO at 150-200 °C (EXAMPLE 16). The starting material IX is prepared according to methods a)-g) and i). In method i) the reductive amination is preferably performed in an one pot proce¬ dure using NaCNBH 3 and molecular sieves in an alcohol such as methanol, Borch et al. J. Am. Chem. Soc. 1971, 93, 2897-2904 (EXAMPLE 12). Alternatively, the reaction can be performed in a two step procedure. In the first step the intermediate imine is formed by reaction of indole derivative, X, with an amine, HNR 8 R 9 , by methods obvious to the chemist skilled in the art. The intermediate imine is reduced with a reducing agent such as NaBH 4 , NaCNBH 3 or LiAIH 4 in an appropriate solvent. The starting material of Formula X is prepared by Vilsmeyer formylation of a corresponding 3-unsubstituted indole using standard conditions (EXAMPLE 11). The 1 -(2-chloroethyl)-2-imidazolidinone and 1 -(2-chloroethyl)-3-(2-propyl)-2-imidazo- lidinone used as reactants above are prepared according to literature procedures in Johnston et al.,J. Med. Chem. 1963, 6, 669-681 , Perregaard et al.,J. Med. Chem. 1992, 35, 1092-1101 and DE-A1 2035370, 1971., Chem. Abstr. 1971 , 74, 87985z. The acid addition salts of the compounds of the invention are easily prepared by methods well known in the art. The base is reacted with either the calculated amount of organic or inorganic acid in an aqueous miscible solvent, such as acetone or ethanol, with isolation of the salt by concentration and cooling, or reacted with an excess of the acid in an aqueous immiscible solvent such as ethyl ether or chloroform, with the desired salt separating directly. These salts may also be prepared by the classical method of double decomposition of appropriate salts. The compounds of general Formula I and the pharmaceutically acceptable acid addition salts thereof may be administered in any suitable way, e.g. orally or parent- erally, and the compounds may be presented in any suitable form for such admini¬ stration, e.g. in the form of tablets, capsules, powders, syrups or solutions or disper¬ sions for injection. An effective daily dose of the a compound of general Formula I or a pharmaceuti- cally acceptable salt thereof is from 0.05 to 500 mg, preferably 0.5 to 100 mg. Examples In the following the invention is further illustrated by way of examples which may in no way be construed as limiting for the invention. 1 H NMR spectra were recorded at 250 MHz on a Bruker AC 250 spectrometer. Deuterated chloroform (99.8% D) or dimethylsulfoxide (99.9% D) were used as solvents. TMS was used as internal reference standard. Chemical shift values are expressed in ppm-values. The following abbreviations are used for multiplicity of NMR signals: s=singlet, d=doublet, t=triplet, q=quartet, qui=quintet, sex=sextet, h=heptet, dd=double doublet, m=multiplet. Content of water in crystalline com¬ pounds was determined by Karl Fischer titration. Results obtained by microanalyses were within + 0.4% of the theoretical values. Mass spectra were obtained on a Quattro MS-MS system from VG Biotech, Fisons Instruments, Manchester, GB. The MS-MS system was connected to an HP 1050 modular HPLC system. A volume of 20 - 50 μl of the sample (0.1 - 0.05 mg/ml) dissolved in a mixture of acetonitrile:water:acetic acid = 250:250:1 (v/v/v) was introduced via the autosampler at a flow of 30 μl/min into the Electrospray Source. Spectra were obtained at two sets of standard operating conditions. One to obtain molecular weight information (MH + ) and another to obtain fragmentation in the source (high cone voltage). The background was subtracted. The relative intensities of the molecular ions obtained in the fragmentation spectrum are given. If the relative intensity of the MH + ion not is given this ion was only obtained in the molecular weight spectra. EXAMPLE 1 3-[5-Chloro-1-(4-fluorophenyl)-3-1 H-indolyljpropanol (1a) A mixture of 3-(5-chloro-3-1 H-indolyl)propanoic acid (17.5 g, 0.078 mol), 4-fluoro- iodobenzene (20.8 g, 0.094 mol), Cul (2.4 g), K 2 C0 3 (21.6 g, 0.16 mol) and N- methyl-2-pyrrolidone (0.20 L) was heated at 165 °C for 7 h. The reaction mixture was cooled to room temperature and water (0.25 L) was added. After acidification with concentrated hydrochloric acid, the mixture was extracted with diethyl ether (2 X 0.30 L) . The combined organic phases were washed with brine (3 X 0.40 L) and dried (Na2Sθ4). Evaporation of the solvents afforded crude 3-[5-chloro-1-(4-fluoro- phenyl)-3-1 H-indolyl]propanoic acid (26 g) as an oil. The oil was dissolved in dry diethyl ether and added to a suspension of lithium aluminum hydride (15 g, 0.40 mol) in dry diethyl ether (0.20 L) over 30 min. After reflux for further 2 h the reaction mixture was cooled to 0 °C and carefully treated with water (15 ml), 4 N aqueous NaOH (15 ml) and then water (75 mL). The resulting mixture was filtered and dried (Na2Sθ4). Evaporation of the solvents afforded the title compound (1 a) as an oil (17.6 g, 74 %). An analytical sample was crystallized from heptane: mp. 67-69 °C; 1 H NMR (CDCI 3 ) δ 1.55 (broad s, 1 H), 2.00 (qui, 2 H), 2.90 (t, 2 H), 3.75 (t, 2 H), 7.10 (s, 1 H), 7.15 (broad d, 1 H), 7.20 (t, 2 H), 7.35 (d, 1 H), 7.40 (dd, 2 H), 7.60 (broad s, 1 H). Anal. (C 17 Hι 5 CIFNO) C, H, N. EXAMPLE 2 2-[5-Chloro-1-(4-fluorophenyl)-3-1 H-indolyloxy]ethanol (2a) A mixture of methyl 5-chloro-1 -(4-fluorophenyl)-3-hydroxy-1 H-indol-2-carboxylate (200 g, 0.62 mol), methyl 2-bromoacetate (125 g, 0.81 mol), K 2 C0 3 (1 12 g, 0.81 mol) and acetone (2.0 L) was refluxed for 18 h. The mixture was cooled to room temperature and filtered, and the solvents were evaporated in vacuo. To the remaining oil (270 g) methanol (1.5 L) and 3 N aqueous KOH (0.6 L) was added. After reflux for 1 h, the solution was cooled to room temperature and acidified by concentrated hydrochloric acid. The product thus precipitated was filtered off and dissolved in ethyl acetate and dried (Na 2 Sθ 4 ). Evaporation of the solvents afforded 2-[2-carboxy-5-chloro-1-(4-fluorophenyl)-3-1 H-indolyloxy]acetic acid (240 g) as an oil which was decarboxylated without further purification. A mixture of the crude dicarboxylic acid, copper (15 g) and N-methyl-2-pyrrolidone was refluxed for 1.5 h. The mixture was cooled to room temperature and water (2.0 L) was added. The product thus precipitated was filtered off and dissolved in ethyl acetate (1.5 L). The solution was washed with brine (3 X 1 L) and dried (Na 2 S0 4 ). Evaporation of the solvents afforded the crude 2-[5-chloro-1-(4-fluorophenyl)-3-1 H-indolyloxy]acetic acid (223 g) which was dissolved in dry diethyl ether (1.5 L). The thus formed solution was added to a suspension of lithium aluminum hydride (70 g, 1.9 mol) in dry diethyl ether (1.0 L) over 45 min. After reflux for additional 0.5 h, the reaction mixture was cooled to 0 °C and carefully treated with water (70 ml), 4 N aqueous NaOH and then water (300 mL). The reaction mixture was filtered and dried (Na 2 S0 4 ). Evaporation of the solvents afforded crystalline title compound (110 g, 55 %). An analytical sample was recrystallized from diethyl ether: mp 118-120 °C; 1 H NMR (CDCI 3 ) δ 2.35 (broad s, 1 H),4.0 (t, 2 H), 4.15 (t, 2 H), 6.85 (s, 1 H), 7.10 (broad d, 1 H), 7.15 (t, 2 H), 7.40 (dd, 2 H), 7.65 (broad s, 1 H). Anal. (C 16 H 13 CIF- N0 2 ) C, H, N. The following compound was prepared in a similar way: 2-[6-Chloro-1-(4-fluorophenyl)-3-1 H-indolyloxy]ethanol (2b): mp 97-98 °C (diethyl ether); 1 H NMR (CDCI 3 ) δ 4.00 (t, 2 H), 4.15 (t, 2 H), 6.80 (s, 1 H), 7.10 (d, 1 H), 7.20 (t, 2 H), 7.40 (s, 1 H), 7.35 (dd, 2 H), 7.60 (d, 1 H). Anal. (C 16 H 13 CIFN0 2 ) C, H, N. EXAMPLE 3 (method a) 1 -[2-[[2-[5-chloro-1 -(4-f luorophenyl)-3-1 H-indolyloxy]ethyl]methylam ino]ethyl]-2- imidazolidinone maleate (4b). To a solution of 2-[5-chloro-1-(4-fluorophenyl)-3-1 - -indolyloxy]ethanol (2a) (4.8, 0.016 mol) and triethylamine (5 mL) in dichloromethane (50 mL), a solution of methanesulfonyl chloride (1.9 mL, 0.025 mol) in dichloromethane (16 mL) was added at 0-5 °C over 0.5 h. After stirring for 3 h at room temperature the reaction mixture was washed with water (2 X 100 mL), dried (Na 2 Sθ 4 ) and the solvents were evaporated in vacuo. Excess of methanesulfonyl chloride was removed by concentrating the remaining oil with toluene in vacuo several times. The crude methanesulfonate of 2a (6.0 g, 0.016 mol) was used without further purification. A mixture of the crude methanesulfonate, 2-(methylamino)ethyl-2-imidazolidinone (4.9 g, 0.034 mol), K2CO3 (4.0 g, 0.029 mol) and methyl isobutyl ketone was refluxed for 18 h. After cooling to room temperature water (100 mL) was added and the resulting mixture was extracted with ethyl acetate (2 X 100 mL). The combined organic phases were washed with water (100 mL) and brine (100 mL), and dried (Na2S04). Evaporation of the solvents and purification by column chromatography on silica gel (eluted with ethyl acetate/ethanol 5:1 containing 4% triethylamine) afforded the title compound (4.2 g, 61%) as an oil. The title compound crystallized as its maleate from ethyl acetate: mp 183-185 °C; 1 H NMR (DMSO- d 6 ) δ 2.85 (s, 3 H), 3.20-3.55 (m, 8 H), 3.65 (broad s, 2 H), 4.40 (broad t, 2 H) 6.05 (s, 2 H), 6.65 (broad s, 1 H), 7.2, (broad d, 1 H), 7.45 (t, 2 H), 7.55 (d, 1 H), 7.69 (7.55, 1 H), 7.60 (dd, 2 H), 7.70 (broad s, 1 H). MS (m/z) 431 (MH + , 2), 170 (33), 1 13 (100); Anal. (C 2 2H24CIFN4θ2-C4H 4 0 4 ) C, H, N. The following compounds were prepared in a similar way: Λ/,/V-Dimethyl-3-[5-chloro-1-(4-fluorophenyl)-3-1 H-indolyl]propylamine fumarate (3a): mp 172-173 °C (ethanol); 1 H NMR (DMSO-αfe) δ 2.00 (qui, 2 H), 2.50 (s, 6 H), 2.65-2.90 (m, 4 H), 6.50 (s, 2 H), 7.20 (broad d, 1 H), 7.40 (t, 2H), 7.45 (d, 1 H), 7.55 (s, 1 H), 7.60 (dd, 2 H), 7.70 (broad s, 1 H). MS (m/z) 331 (MH + , 37), 286 (71), 258 (100), 251 (62); Anal. (Cι 9 H2oCIFN2-C 4 H4θ4) C, H, N. 1 -[2-[[3-[5-chloro-1 -(4-fluorophenyl)-3-1 H-indolyl]propyl]methylamino]ethyl]-2- imidazolidinone fumarate (3b): mp 132-134 °C (ethanol); 1 H NMR (DMSO- d 6 ) δ 1.80-2.00 (m, 2 H), 2.40 (s, 3 H), 2.55-2.80 (m, 6 H), 3.15-3.25 (m, 4H), 3.30-3.40 (m, 2 H), 6.30 (s, 1 H), 6.60 (s, 2 H), 7.20 (broad s, 1 H), 7.40 (t, 2 H), 7.45 (d, 1 H), 7.55 (s, 1 H), 7.60 (dd, 2 H), 7.70 (broad s, 1 H). MS (m/z) 429 (MH + , 20), 286 (4), 113 (100); Anal. (C23H26CIFN 4 0-C 4 H 4 θ4) C, H, N. 5-Chloro-1-(4-fluorophenyl)-3-[3-(4-morpholinyl)propyl]-1 H-indole maleate (3c): mp 144-145 °C (ethyl acetate); 1 H NMR (DMSO- d 6 ) δ 2.05 (qui, 2 H), 2.80 (t, 2H), 3.05- 3.35 (m, 6H), 3.70-3.95 (m, 4 H), 6.05 (s,2 H), 7.20 (broad d, 1 H) 7.40 (t, 2 H), 7.50 (d, 1 H), 7.55 (s, 1 H), 7.60 (dd, 2 H), 7.75 (broad s, 1 H). MS (m/z) 373 (MH + , 100), 286 (89), 258 (77), 251 (41) 100 (37); Anal. (C 2 ιH22CIFN2θ-C 4 H 4 θ4) C, H, N. 5-Chloro-1-(4-fluorophenyl)-3-[3-(4-piperidinyl)propyl]-1 H-indole hydrochloride (3d): mp 219-212 °C (acetone); 1 H NMR (CDCI 3 ) δ 1.70-2.00 (m, 4 H), 2.20-2.50 (m, 4 H), 2.50-2.75 (m, 2 H), 2.85 (t, 2 H), 2.95-3.05 (m, 2 H), 3.40-3.60 (m, 2 H), 7.15 (bd, 1 H), 7.20 (t, 2 H), 7.35 (d, 1 H), 7.35 (s, 1 H), 7.40 (dd, 2 H), 7.50 (broad s, 1 H). MS (m/z) 371 (MH + , 100), 286 (44), 258 (38), 251 (22), 98 (30); Anal. (C 2 2H 2 4CIFN 2 -HCI) C, H, N. N,N-Dimethyl-2-[5-chloro-1-(4-fluorophenyl)-3-1 H-indolyloxyjethylamine sesqui fu¬ marate (4a): mp 165-167 °C (ethanol); 1 H NMR (DMSO-ofe) δ 2.60 (s, 6 H), 3.15 (t, 2 H), 4.30 (t, 2 H), 6.60 (s, 3 H), 7.20 (broad d, 1 H), 7.40 (t, 2 H), 7.45 (s, 1 H), 7.50 (d, 1 H), 7.60 (dd, 2 H), 7.65 (broad s, 1 H). MS (m/z) 333 (MH + ), 72 (100); Anal. (C 18 H 18 CIFN2θ-1.5(C 4 H 4 θ4))) C, H, N. 1 -[2-[[2-[5-Chloro-1 -(4-fiuorophenyl)-3-1 H-indolyloxy]ethyl]ethylamino]ethyl]-2- imidazolidinone maleate (4c): mp 155-157 °C (ethyl acetate); 1 H NMR (DMSO- d 6 ) δ 1.30 (t, 3 H), 3.20-3.55 (m, 10 H), 3.55-3.80 (m, 2 H), 4.35-4.50 (m, 2 H), 6.05 (s, 2 H), 6.65 (s, 1 H), 7.25 (broad d, 1 H), 7.40 (t, 2 H), 7.50 (d, 1 H), 7.55 (s, 1 H), 7.60 (dd, 2 H), 7.70 (broad s, 1 H). MS (m/z) 445 (MH + , 3), 184 (41 ), 1 13 (100); Anal. (C 2 3H26CIFN4θ2-C 4 H4θ 4 ) C, H, N. 1 -[2-[[2-[5-Chloro-1 -(4-fluorophenyl)-3-1 - -indolyloxy]ethyl](3-propynyl)amino]ethyl]- 2-imidazolidinone oxalate (4d): mp 139-141 °C (acetone); 1 H NMR (DMSO- d 6 ) δ 2.75 (t, 2 H), 3.00 (t, 2 H), 3.10-3.30 (m, 5 H), 3.40 (t, 2 H), 3.65 (broad s, 2 H), 4.15 (t, 2 H), 6.25 (broad s, 1 H),7.20 (broad d, 1 H), 7.40 (t, 2 H), 7.45 (s, 1 H), 7.50 (d, 1 H), 7.55 (broad s, 1 H), 7.60 (dd, 2 H). MS (m/z) 455 (MH + , 3), 194 (41 ), 1 13 (100); Anal. (C24H24CIFN 4 θ2-C2H 2 θ4) C, H, N. 5-Chloro-1-(4-fluorophenyl)-3-[2-(1-piperidinyl)ethoxy]-1 H-indole (4e): mp 82-84 °C (/--heptane); 1 H NMR (CDCI 3 ) δ 1.40-1.55 (m, 2 H), 1.55-1.70 (m, 4 H), 2.50 (t, 4H), 2.85 (t, 2 H), 4.15 (t, 2 H), 6.85 (s, 1 H), 7.15 (broad d, 1 H), 7.20 (t, 2 H), 7.30 (d, 1 H), 7.40 (dd, 2 H), 7.65 (broad s, 1 H). MS (m/z) 373 (MH + , 1), 260 (2), 1 12 (100); Anal. (C21H22CIFN2O) C, H, N. 5-Chloro-1-(4-fluorophenyl)-3-[2-(4-morpholinyl)ethoxy]-1 -/-indole maleate (4f): mp 185-187 °C (ethyl acetate); 1 H NMR (DMSO- 6 ) δ 3.15-3.40 (m, 4 H), 3.40-3.60 (m, 2 H), 3.75-3.95 (m, 4 H), 4.40 (t, 2 H), 6.10 (s, 2 H), 6.25 (broad d, 1 H), 7.40 (t, 2 H), 7.50 (d, 1 H), 7.55 (s, 1 H), 7.60 (dd, 2 H), 7.70 (broad s, 1 H), MS (m/z) 375 (MH + , 2), 114 (100); Anal. (C 2 oH2oCIFN2θ2-C4H4θ 4 ) C, H, N. 1 -[2-[[2-[6-chloro-1 -(4-f luorophenyl)-3-1 H-indolyloxy]ethyl]methylam ino]ethyl]-2- imidazolidinone (4h): mp 100-102 °C (diethyl ether); 1 H NMR (CDCI 3 ) δ 2.40 (s, 3 H), 2.65 (t, 2 H), 2.90 (t, 2 H), 3.30-3.40 (m, 4 H), 3.45-3.60 (m, 2 H), 4.10 (t, 2 H), 4.50 (broad s, 1 H), 6.80 (s, 1 H), 7.10 (broad d, 1 H), 7.20 (t, 2 H), 7.35 (broad s, 1 H), 7.40 (dd, 2 H), 7.60 (d, 1 H); MS (m/z) 431 (MH + , 3), 170 (65), 1 13 (100); Anal. (C22H 24 CIFN 4 0 2 ) C, H, N. 1 -[2-[[2-[6-Chloro-1 -(4-fluorophenyl)-3-1 H-indolyloxy]ethyl]methylamino]ethyl]-3-(2- propyl)-2-imidazolidinone oxalate (4i): mp 165-167 °C (acetone); 1 H NMR (DMSO- d 6 ) δ 1.00 (d, 6 H), 2.80 (s, 3H), 3.10-3.55 (m, 10 H), 3.90 (h, 1 H), 4.40 (m, 2 H), 7.15 (broad d, 1 H), 7.40 (t, 2 H), 7.45 (s, 1 H), 7.50 (broad s, 1 H), 7.60 (dd, 2 H), 7.65 (d, 1 H); MS (m/z) 473 (MH + , 10), 212 (62), 155 (100); Anal. (C25H30CI- FN4O2O2H2O4) C, H, N. Λ/,Λ/-Dimethyl-2-[6-chloro-1-(4-fluorophenyl)-3-1 H-indolyloxy]ethylamine (4j): mp 66- 68 °C; 1 H NMR (CDCI 3) δ 2.40 (s, 6 H), 2.80 (t, 2 H), 4.15 (t, 2 H), 7.80 (s, 1 H), 7.10 (broad d, 1 H), 7.20 (t, 2 H), 7.35 (broad s, 1 H), 7.40 (dd, 2 H), 7.60 (d, 1 H). MS (m/z) 333 (MH + ), 72 (100); Anal. (C 18 H 18 CIFN 2 0) C, H, N. 1 -[2-[1 -[2-[5-Chloro-1 -(4-fluorophenyl)-3-1 H-indolyloxy]ethyl]-4-piperidinyl]ethyl]-2- imidazolidinone (4k): mp 134-136 °C; 1 H NMR (CDCI3) δ 1.20-1.50 (m, 5 H), 1.70- 1.90 (m, 2 H), 2.05-2.20 (m, 2 H), 2.85 (t, 2 H), 2.95-3.05 (m, 2 H), 3.25 (t, 2 H), 3.40 (s, 4 H), 4.15 (t, 2 H), 4.45 ( broad s, 1 H), 6.80 (s, 1 H), 7.15 ( broad d, 1 H), 7.20 (t, 2 H), 7.30 (d, 1 H), 7.40 (dd, 2 H), 7.65 (broad s, 1 H). MS (m/z) 485 (MH + , 8), 224 (100), 99 (67); Anal. (C26H30CIFN4O2) C, H, N. Λ/-methyl-1 -[2-[5-chloro-1 -(4-fluorophenyl)-3-1 H-indolyloxy]ethyl]-4-piperid ine- carboxamide (4n): mp 152-154 °C; 1 H NMR (CDCI3) δ 1. 65-1.95 (m, 4 H), 2.00- 2.25 (m, 3 H), 2.80 and 2.85 (two singlets due to two rotamers, 3 H), 2.85 (t, 2 H), 3.00-3.10 (m, 2 H), 4.15 (t, 2 H), 5.50 (broad s, 1 H), 6.80 (s, 1 H), 7.15 (broad d, 1 H), 7.20 (t, 2 H), 7.30 (d, 1 H), 7.40 (dd, 2 H), 7. 65 (broad s, 1 H). MS (m/z) 430 (MH + , 7), 169 (100), 1 10 (52) Anal. (C23H25CIFN3O2) C, H, N. 6-Chloro-1-(4-fluorophenyl)-2-(1-pyrrolidinyl)ethoxy-1 H-indole (4o): mp 60-62 °C; 1 H NMR (CDCI3) δ 1.75-1.90 (m, 4 H), 2.60-2.75 (m, 4 H), 3.00 (t, 2 H), 4.15 (t, 2 H), 6.80 (s, 1 H), 7.10 (broad d, 1 H), 7.20 (t, 2 H), 7.35 (broad s, 1 H), 7.40 (dd, 2 H), 7.60 (d, 1 H). MS (m/z) 359 (MH + ), 98 (100); Anal. (C20H2 0 CIFN2O) C, H, N. 6-Chloro-1-(4-fluorophenyl)-2-(1-piperidinyl)ethoxy-1 H-indole (4p): mp 67-69 °C; 1 H NMR (CDCI3) δ 1.40-1.55 (m, 2 H), 1.55-1.70 (m, 4 H), 2.50-2.65 (m, 4 H), 2.85 (t, 2 H), 4.20 (t, 2 H), 7.80 (s, 1 H), 7.10 (broad d, 1 H), 7.20 (t, 2 H), 7.35 (broad s, 1 H), 7.40 (dd, 2 H), 7.60 (d, 1 H). MS (m/z) 373 (MH + ), 112 (100); Anal. (C21H22CIFN2O) C, H, N. Λ/,Λ/-Dimethyl-2-[5-chloro-1 -(4-fluorophenyl)-3-1 H-indolylthio]ethylamine hydrochlo- ride (4q): mp 200-202 °C (acetone); 1 H NMR (DMSO-d 6 ) δ 2.70 (s, 6 H), 3.05-3-30 (m, 4 H), 7.30 (dd, 1 H), 7.45 (t, 2 H), 7.55 (d, 1 H), 7.75 (broad s, 1 H), 7.70 (dd, 2 H), 8.10 (s, 1 H). MS (m/z) 349 (MH + , 1 ), 276 (100), 104 (34), 58 (64); (C 18 H 18 CIFN 2 S-HCI) C, H, N. 1 -[2-[[2-[5-Chloro-1 -(4-fluorophenyl)-3-1 H-indolylthio]ethyl]methylamino]ethyl]-2- imidazolidinone (4r) mp 65-67 ° C (acetone); 1 H NMR (CDCI 3 ) δ 2.95 (s, 3 H), 3.35- 3.75 (m, 12 H), 4.90 (s, 1 H), 7.35 (t, 2 H), 7.40 (bd, 1 H), 7.50 (d, 1 H), 7.65 (d, 1 H), 7.75 (s, 1 H), 7.85 (broad s, 1 H); MS (m/z) 447 (MH + , 4), 276 (100), 202 (13), 113 (51); Anal. (C22H24CIFN4OS -HCI-0.85H 2 O) C, H, N. 1 -[2-[[5-chloro-1 -(4-fluorophenyl)-3-1 H-indolylmethyl]methylamino]ethyl]-2-i- midazolidinone (4s): mp 141-143 °C (ethyl acetate) ; 1 H NMR (CDCI3) δ 2.30 (s, 3 H), 2.60 (t, 2 H), 3.25-3.50 (m, 6 H), 3.70 (s, 2 H), 4.50 (broad s, 2 H), 7.10-7.25 (m, 4 H), 7.35 (d, 1 H), 7.40 (dd, 2 H), 2.80 (broad s, 1 H) ; MS (m/z) 401 (MH + , 3), 258 (64), 223 (100), 222 (80), 162 (60). Anal. (C 2 ιH 2 2CIFN 4 0) C, H, N. 1 -[4-[[5-chloro-1 -(4-fl uorophenyl)-3-1 H-indolylmethyl]methylamino]butyl]-2-i- mimidazolidinone oxalate (4t):mp 155-157 °C (acetone); 1 H NMR (DMSO-d 6 ) δ 1.80-1.95 (m, 4 H), 2.80 (s, 3 H), 3.10-3.35 (m, 6 H), 3.35-3.50 (m, 2H), 4.60 (s, 2 H), 6.65-6.75 (m, 1 H), 7.20 (broad d, 1 H), 7.35-7.50 (m, 3 H), 7.60 (dd, 2 H), 7.70 (dd, 1 H), 7.80 (broad s, 1 H); MS (m/z) 429 (MH + ), 258 (100), 223 (27), 141 (91 ). Anal. (C 2 3H26CIFN 4 0-C 2 H2θ4) C, H, N. 1 -[3-[[2-[5-chloro-1 -(4-fluorophenyl)-3-1 H-indolyl]ethyl]methylamino]propyl]-2-i- midazolidinone hydrochloride (4u): mp 171-173 °C (acetone); 1 H NMR (CDCI3) δ 2.10-2.30 (m, 2 H), 2.90 (s, 3 H), 3.05-3.60 (12 H), 4.60 (broad s, 1 H), 7.15-7.35 (m, 5 H), 7.40 (dd, 2 H), 7.60 (broad s, 1 H); MS (m/z) 429 (MH + , 2), 272 (34), 237 (20), 127 (100), 99 (44). Anal. (C23H26CIFN4OΗCI) C, H, N. 1 -[2-[[2-[5-chloro-1 -(4-fluorophenyl)-3-1 H-indolyl]ethyl]methylamino]ethyl]-2-imidazo- lidinone maleate (4v): mp 137-139 °C ; 1 H NMR (DMSO-d 6 ) δ 2.95 (s, 3 H), 3.10- 3.55 (m, 12 H), 6.05 (s, 2 H), 6.65 (broad s, 1 H), 7.25 (broad d, 1 H), 7.40-7.55 (m, 3 H), 7.60 (dd, 2 H), 7.65 (s, 1 H), 7.65 (broad s, 1 H); MS (m/z) 415 (MH + ), 272 (33), 237 (28), 113 (100). Anal. (C22H24CIFN 4 0-C 4 H 4 θ 4 ) C, H, N. EXAMPLE 4 5-Chloro-2,3-dihydro-1 -(4-fluorophenyl)-3-1 H-indolone (5). 5 To a mixture of Na 2 S0 -7H 2 0 (90 g, 0.36 mol) and water (1.8 L) was at 60 °C added ethanol (1.5 L) and 3-acetoxy-5-chloro-1-(4-fluorophenyl)-1 H-indole (60 g, 0.20 mol). The resulting mixture was refluxed for 1 h and after stirring at room tem¬ perature for further 18 h the precipitate was filtered off, washed with water (300 ml) at 60 °C and dried in vacua over night at 60 °C affording the title compound (44.3 g, 10 85 %): mp 99-101 °C; 1 H NMR (CDCI 3 ) δ 4.20 (s, 2 H), 7.10 (s, 1 H), 7.10 (t, 2 H), 7.25 (dd, 2 H), 7.40 (broad d, 1 H), 7.60 (broad s, 1 H). Anal. (C 14 H 9 CIFN0) C, H, N. EXAMPLE 5 (method b) (S)-NN-Dimethyl-2-[5-chloro-1 -(4-fluorophenyl)-3-1 H-indolyloxy]-1-methylethyl- 15 amine oxalate (6a). A mixture of 5-chloro-2,3-dihydro-1-(4-fluorophenyl)-3-1 H-indolone (5) (1.1 g, 5.7 mmol), (S)-Λ/-Ethoxycarbonylalaninol (2.9 g, 17 mmol), p-toluenesulfonic acid (0.8 g) and toluene (50 mL) was refluxed for 18 h. Evaporation of the solvents and purifi¬ cation by column chromatography (eluted with ethyl acetate/heptane 1 :2) afforded 0 the crude (S)-N-methyl-2-[5-chloro-1-(4-fluorophenyl)-3-1 H-indolyloxy]-N-ethoxycar- bonyl-1-methylethylamine as an oil (1.1 g). The crude carbamate was dissolved in dry diethyl ether (50 mL) and added to a suspension of lithium aluminum hydride (0.5 g, 13 mmol) in dry diethyl ether (50 mL). After reflux for 2 h the reaction mixture was cooled to 0 °C and carefully treated with water (1 mL) and 4 N aqueous NaOH 5 (1 mL). The precipitate was filtered off and extracted with dichloromethane (3 X 50 mL). The combined organic phases were dried (Na 2 S0 ) and the solvents were evaporated affording the crude Λ/-methyl compound as an oil (0.6 g). A solution of methyl chloroformate (0.20 g, 2.1 mmol) in dichloromethane (20 mL) was added to a mixture of the crude Λ/-methyl compound, K 2 CO 3 (0.3 g) and dichloromethane (20 30 mL). After reaction for 3.5 h the reaction mixture was filtered and the solvents were evaporated. The remaining oil was suspended in dry diethyl ether (20 mL) and added to a suspension of lithium aluminum hydride in dry diethyl ether (20 mL). The resulting mixture was refluxed for 2 h and subsequently cooled to 0 °C. The reaction mixture was treated with water (0.5 mL) and 4 N aqueous NaOH (0.5 mL). The precipitate was filtered off and extracted with dichloromethane (3 X 50 mL). The combined organic phases were dried (Na2Sθ4) and the solvents were evaporated affording an oil. The product was purified by column chromatography (eluted with ethanol/ethyl acetate 6:1 containing 4% triethylamine) giving the title compound 6a (0.30 g, 23 %) as an oil which was precipitated as its oxalate in acetone: mp 161- 163 °C; [α ] 22 D +11.4° (c 1.0; CH 3 OH); 1 H NMR (DMSO-αfe) δ 1.35 (d, 3 H), 2.80 (s, 6 H), 3.80 (sex, 1 H), 4.30 (m, 2 H), 7.20 (broad d, 1 H), 7.40 (t, 2 H), 7.50 (d, 1 H), 7.55 (s, 1 H), 7.60 (dd, 2 H), 7.75 (broad s, 1 H). MS (m/z) 347 (MH + ), 260 (3), 86 (100); Anal. (C 19 H 2 oCIFN2θ-C 2 H2θ4) C, H, N. The following compounds were prepared accordingly: (fl)-Λ/,Λ/-Dimethyl-2-[5-chloro-1 -(4-fluorophenyl)-3-1 H-indolyloxy]-1 -methylethyl- amine oxalate (6b): mp 162-164 °C (acetone); [α] 22 D -7.0° (c 1.0; CH 3 OH); 1 H NMR (DMSO-d 6 ) 1.35 (d, 3 H), 2.80 (s, 6 H), 3.80 (sex, 1 H), 4.30 (m, 2 H), 7.20 (broad d, 1 H), 7.40 (t, 2 H), 7.50 (d, 1 H), 7.55 (s, 1 H), 7.60 (dd, 2 H), 7.75 (broad s, 1 H). MS (m/z) 347 (MH + ), 260 (3), 86 (100); Anal. (C 19 H 2 oCIFN2θ-C 2 H2θ4) C, H, N. NN-Dimethyl-1 ,1-dimethyl-2-[5-chloro-1 -(4-fluorophenyl)-3-1 H-indolyloxyjethyl- amine oxalate (6c): mp 156-157 °C (acetone); 1 H NMR (DMSO- d 6 ) δ 1.45 (s, 6 H), 2.80 (s, 6 H), 4.20 (s, 2 H), 7.25 (broad d, 1 H), 7.40 (t, 2 H), 7.50 (d, 1 H), 7.55 (s, 1 H), 7.60 (dd, 2 H), 7.80 (broad s, 1 H). MS (m/z) 361 (MH + ), 260 (41 ), 100 (100); Anal. (C20H22CIFN2OO2H2O4) C, H, N. EXAMPLE 6 (method b) (S)-1-Methyl-2-pyrrolidinylmethoxy-5-chloro-1-(4-fluorophenyl)-1 /- -indole oxalate (7a). A mixture of 5-chloro-2,3-dihydro-1 -(4-fluorophenyl)-3-1 /- -indolone (5) (1.0 g, 3.8 mmol), (S)-N-ethoxycarbonylprolinol (2.0 g, 12 mmol), p-toluenesulfonic acid (5.0 g) and toluene (500 mL) was refluxed for 18 h. Evaporation of the solvents and purification by column chromatography (eluted with ethyl acetate/heptane 1 :2) afforded the crude (S)-1-methoxycarbonyl-2-pyrrolidinylmethoxy-5-chloro-1-(4- fluorophenyl)-1 /-/-indole as an oil (1.1 g). A solution of the crude carbamate in dry diethyl ether (20mL) was added to a suspension of lithium aluminum hydride (0.8 g, 21 mmol) in dry diethyl ether (30 mL). After reflux for 0.5 h the reaction mixture was cooled to 0 °C and treated with water (1 mL) and 4 N aqueous NaOH (1 mL). The precipitate was filtered off and extracted with dichloromethane (3 X 50 mL). The combined organic phases were dried (Na 2 Sθ 4 ) and the solvents were evaporated affording the title compound (7a) as an oil (1 g). Purification by column chromatogra- phy on silica gel (eluted with ethyl acetate/heptane 1 :1 containing 4% triethylamine) afforded pure title compound (7a) (0.7 g, 51 %) as an oil. The title compound was precipitated as its oxalate in acetone: mp 177-179 °C; [α ] 22 D +8.2° (c 1.0; CH 3 OH); 1 H NMR (DMSO-αfe) δ 1.75-2.10 (m, 3 H), 2.15-2.35 (m, 1 H), 2.90 (s, 3 H), 3.00-3- 15 (m, 1 H), 3.50-3.65 (m, 1 H), 3.70-3.80 (m, 1 H), 4.35 (d, 2 H), 7.20 (broad d, 1 H), 7.40 (t, 2 H), 7.50 (d, 1 H), 7.55 (s, 1 H), 7.60 (dd, 2 H), 7.70 (broad s, 1 H). MS (m/z) 359 (MH + , 1), 260 (4), 98 (100); Anal. (C 2 oH2oCIFN 2 θ-C2H 2 0 4 ) C, H, N. The following compound was prepared accordingly: (S)-1-Methyl-2-pyrrolidinylmethoxy-5-chloro-1-(4-fluorophenyl)-1 H-indole oxalate (7b): mp 176-178 °C; [α ( c 1.0; CH 3 OH); 1 H NMR (DMSO-αf 6 ) δ 1.75-2.10 (m, 3 H), 2.15-2.35 (m, 1 H), 2.90 (s, 3 H), 3.00-3-15 (m, 1 H), 3.50-3.65 (m, 1 H), 3.70-3.80 (m, 1 H), 4.35 (d, 2 H), 7.20 (broad d, 1 H), 7.40 (t, 2 H), 7.50 (d, 1 H), 7.55 (s, 1 H), 7.60 (dd, 2 H), 7.70 (broad s, 1 H). MS (m/z) 359 (MH + ), 260 (4), 98 (100); Anal. (C 20 H 20 CIFN 2 OO 2 H 2 O4) C, H, N. EXAMPLE 7 (method c) (H)-1 -[2-[2-[5-Chloro-1 -(4-fluorophenyl)-3-1 H-indolyloxymethyl]-1 -py rro I idi nyl]ethyl]- 2-imidazolidinone oxalate (8a) A mixture of (H)-1-methoxycarbonyl-2-pyrrolidinylmethoxy-5-chloro-1-(4-fluorophe- nyl)-1 H-indole (3.6 g, 0.016 mol) (prepared as the corresponding S-isomer in EXAM- PLE 6), 1-propanol (75 mL), water (50 mL) and NaOH (2.5 g) was refluxed for 6 days. The volatile solvents were evaporated in vacuo and water (250 mL) was added. The resulting mixture was extracted with diethyl ether (2 X 250 mL) and the combined organic phases were dried (MgSθ 4 ). Evaporation of the solvents afforded the crude (H)-2-pyrrolidinylmethoxy-5-chloro-1-(4-fluorophenyl)-1 H-indole (3.3 g) as an oil. A mixture of the crude (H)-2-pyrrolidinylmethoxy-5-chloro-1-(4-fluorophenyl)- 1 H-indole, 1-(2-chloroethyl)-2-imidazolidinone (2.1 g), K 2 CO3 (2.0 g), Kl (0.3 g) and methyl isobutyl ketone (50 mL) was refluxed for 18 h. After cooling to room tempera¬ ture the reaction mixture was poured into water (100 mL) and extracted with ethyl acetate (2 x 100 mL). The combined organic phases were washed with brine, dried (Na2S04) and the solvents were evaporated in vacuo. The remaining oil, 4.0 g, was purified by column chromatography on silica gel (eluent ethyl acetate/ethanol 9:1 containing 4% triethylamine) affording the pure title compound (0.9 g, 12 %) as an 5 oil, that precipitated as oxalate in acetone: mp 84-87 °C; 1 H NMR (DMSO- d 6 ) δ 1.70- -2.30 (m, 4H), 2.90-3.85 (m, 1 1 H), 4.20-4.40 (m, 2H), 6.50 (s, 1 H), 7.20 (broad d, 1 H), 7.40 (t, 2H), 7.45 (d, 1 H) , 7.50 (s, 1 H), 7.60 (dd, 2H), 7.65 (broad s, 1 H). Anal. (C 2 4H2 6 CIFN 4 θ2-C2H2θ4) C, H, N; MS (m/z) 457 (MH + , 3), 196 (62), 113 (100). The following compound was prepared accordingly: 10 (S)-1 -[1 -methyl-2-[[2-[5-chloro-1 -(4-fluorophenyl)-3-1 H-indolyloxy]ethyl]methyl- amino]ethyl]-2-imidazolidinone oxalate (8b): mp 102-104 °C; 1 H NMR (DMSO-cfe) δ 1.35 (d, 3 H), 2.75 (s, 3 H), 3.10-3.30 (m, 4 H), 3.30-3.50 (m, 4 H), 3.75-3.90 (m, 1 H), 4.20-4.35 (m, 2H), 6.50 (s, 1 H), 7.20 (broad d, 1 H), 7.40 (t, 2 H), 7.45 (s, 1 H), 7.50 (d, 1 H), 7.60 (dd, 2 H), 7.65 (broad s, 1 H). MS (m/z) 445 (MH + , 2), 184 (19), 15 1 13 (100); Anal. (C2 3 H26CIFN 4 θ2-C 2 H2θ4) C, H, N. EXAMPLE 8 (method d) Λ/,Λ/-Dimethyl-2-[5-chloro-1 -(4-fluorophenyl)-2-hydroxymethyl-3-1 H-indolyloxy]- ethylamine hydrochloride (9) 20 A solution of N,Λ/-dimethyl-2-chloroacetamide (28 g) in acetone (300 mL) was added dropwise during 1 hour to a mixture of 5-chloro-1-(4-fluorophenyl)-3-hydroxy- 1 H-indole-2-carboxylic acid methyl ester (64 g) (prepared according to the method of Unangst et al. J.Heterocyc.Chem. 1984, 21, 709-714 and 1987, 24, 81 1-815) and potassium carbonate (40 g) in acetone (500 mL) kept at reflux. The mixture was 5 refluxed for another 3 hours and subsequently worked-up. The resulting crude acet- amide derivative crystallized from cyclohexane. Yield 72 g. Mp: 124-125 °C. To a suspension of UAIH4 pellets (10 g) in dry THF (200 mL) kept at gentle reflux was added dropwise a solution of the acetamide derivative (35 g) in dry THF (300 mL). After reflux for 2 hours the mixture was cooled on an ice bath and excess UAIH4 0 was hydrolyzed by cautiously adding a mixture of 10 % water in THF. Inorganic salts were filtered off and the solvent evaporated in vacuo leaving the title com¬ pound as a visceous oil. Yield: 19 g. The hydrochloric acid salt of the title compound 9 crystallized from acetone by addition of a solution of hydrogenchloride gas in diethyl ether.mp 185-186 °C; 1 H NMR (DMSO-d 6 ) δ 2.90 (s, 6H), 3.60 (t, 2H), 4.40 (s, 2H), 4.45 (t, 2H),7.05 (d, 1 H), 7.10 (dd, 1 H), 7.40 (t, 2H), 7.55 (dd, 2H), 7.85 (d, 1 H). MS (m/z) 363 (MH + ), 72 (100); Anal (C 19 H 2 oCIFN 2 θ 2 -HCI) C, H, N. EXAMPLE 9 (method e) Λ/,N-Dimethyl-2-[5-chloro-1 -(4-fluorophenyl)-2-methyl-3-1 H-indolyloxy]ethylamine oxalate (10) Triethylamine (1 g) was added to a solution of N,N-dimethyl-2-[5-chloro-1-(4-fluoro- phenyl)-2-hydroxymethyl-3-1 H-indolyloxy]ethylamine 9 (3 g) in dichloromethane (100 mL) cooled to -10 °C. A solution of methanesulfonylchloride (1.1 g) in dichloromethane (25 mL) was added dropwise at -10 to 0 °C. After stirring for 1/2 h at 0 °C ice cooled water was added and the organic phase was subsequently worked up leaving the 2-chloromethylindole derivative as an oil. This oil was used immediately without further purification. To a solution of the oil in dry THF was added LiAIH 4 (1 g). After refluxing for 1 h, the mixture was cooled on an ice bath and excess UAIH 4 was hydrolyzed by cautiously adding a mixture of 10 % water in THF. Inorganic salts were filtered off and the solvent evaporated in vacuo . The resulting visceous oil was subjected to column chromatography on silica gel (eluted with 4 % triethylamine in ethyl acetate) yielding the pure title compound as an oil. Yield: 0.6 g. The oxalic acid salt 10 crystallized from 2-propanol. mp 236-237 °C; 1 H NMR (DMSO-d 6 ) δ 2.15 (s, 3H), 2.85 (s, 6H), 3.40 (t, 2H), 4.35 (t, 2H),7.00 (d, 1 H), 7.05 (dd, 1 H), 7.40 (t, 2H), 7.45 (dd, 2H), 7.70 (d, 1 H). MS (m/z) 347 (MH + ), 274 (6), 223 (36), 222 (20), 72 (100); Anal (C 19 H 20 CIFN 2 O- C 2 H 2 0 4 ) C, H, N. EXAMPLE 10 2-(5-Chloro-3-1 H-indolylthio)ethanol (11). A mixture of 5-chloro-2,3-dihydro-1-(4-fluorophenyl)-3-1 H-indolone (5) (25.0 g, 0.10 mol), mercaptoacetic acid (25 g, 0.27 mol), p-toluenesulfonic acid (5.0 g) and toluene (500 mL) was refluxed for 18 h. Evaporation of the solvents afforded crude 2-[5-chloro-1-(4-fluorophenyl)-3-1 H-indolylthio]acetic acid which was isolated as an oil and used without further purification. A solution of the crude acid in dry tetrahyrofuran (200 mL) was added to a suspension of lithium aluminum hydride (7.5 g, 0.20 mol) in dry tetrahyrofuran (200 mL) during 15 min. After reflux for 1 h the reaction mixture was cooled to 0 ° C and carefully treated with water (5 mL) and 28% aqueous NaOH (5 mL). The precipitate was filtered off and extracted with dichloromethane (3 X 500 mL). The combined organic phases were dried (MgSθ 4 ) and the solvents were evaporated affording the title compound (11) as an oil (25 g). Purification by column chromatography on silica gel (eluted with ethyl acetate/ heptane 1 :2) afforded pure title compound (11 ) (12 g, 40 %) as an oil: 1 H NMR (CDCI 3 ) δ 2.10-2.50 (broad s, 1 H), 2.95 (t, 2 H), 3.70 (t, 2 H), 7.20 (broad d, 1 H), 7.25 (t, 2 H), 7.35 (d, 1 H), 7.40 (dd, 2 H), 7.45 (s, 1 H), 7.80 (broad s, 1 H). Anal. (C 16 Hι 3 CIFNS) C, H, N. EXAMPLE 11 5-chloro-1 -(4-fluorophenyl)indol-3-carbaldehyde (12a) Phosphorus oxychloride (12.5 g, 0.081 mol) was added to Λ/,N-dimethyiformamide (29.5 g, 0.19 mol) at 0-5 °C. After stirring for 10 minutes a solution of 5-chloro-1-(4- fluorophenyl)indole (20 g, 0.081 mol) in N,N-dimethylformamide (50 mL) was added at 0-5 °C. The reaction mixture was stirred for 0.5 h and subsequently poured into ice. The resulting mixture was made alkaline with concentrated NaOH and after stirring for 1 h at room temperature the mixture was extracted with diethyl ether (2 X 250 mL). The combined organic phases were dried (Na 2 Sθ 4 ),the solvents evapora- ted and the remaining oil was purified by column chromatography (eluted with ethyl acetate/heptane 1 :1) affording pure title compound 20.1 g (90 %) which crystalized from heptane: mp 152-154 °C ; 1 H NMR (CDCI 3 ) δ 7.20-7.35 (m, 4 H), 7.50 (dd, 2 H), 7.85 (s, 1 H), 8. 35 (s, 1 H), 10.05 (s, 1 H). Anal. (C 15 H 9 NO) C, H, N. EXAMPLE 12 (method i) Λ/,Λ/-Dimethyl-[5-chloro-1-(4-fluorophenyl)-3-1 H-indolyl]methylamine maleate (13a) A mixture of 5-chloro-1-(4-fluorophenyl)indol-3-carbaldehyde (2.5 g, 0.0091 mol) dimethylamine hydrochloride (1.5 g, 0.018 mol), 3 A molecular sieves (5 g) and methanol (50 mL) was stirred at room temperature for 1 h. Sodium cyanoborohy- dride (0.6 g, 0.095 mol) was added and the mixture was stirred for 24 h at room temperature. Further 3 A molecular sieves (5 g) and sodium cyanoborohydride (0.6 g, 0.095 mol) was added and the mixture stirred for further 24 h at room tempera¬ ture. The precipitate was filtered off and the solvents evaporated. The remaining oil was purified by column chromatography (eluted with ethyl acetate/heptane 1 :1 containing 4 % triethylamine) affording pure title compound as an oil (2.1 , 76 %). The maleate of 13a was crystalized from ethanol: mp 174-177 °C ; 1 H NMR (DMSO-d . ) δ 2.80 (s, 6 H), 4.50 (s, 2 H), 6.05 (s, 2 H), 7.30 (broad d, 1 H), 7.40- 7.55 (m, 3 H), 7.70 (dd, 2 H), 7.95 (s, 1 H), 8.10 (broad s, 1 H); MS (m/z)303 (MH + ), 258 (20), 223 (61 ), 222 (100), 162 (70), 127 (61 ). Anal. (C 17 H 16 CIFN 2-C 4 H 4 θ4) C, H, N. The following compound was prepared in a similar way: N-methyl-[5-chloro-1 -(4-fluorophenyl)-3-1 H-indolylmethyl]amine hydrochloride (13b): mp 236-238 °C (acetone); 1 H NMR (DMSO- d 6 ) δ 2.55 (s, 3 H), 4.35 (s, 2H), 7.25 (broad d, 1 H), 7.40-7.55 (m, 3 H), 7.65 (dd, 2 H), 7.95 (s, 1 H), 8.05 (broad s, 1 H) ; MS (m/z) 289 (MH + , 1), 258 (14), 223 (45) 222 (100), 162 (62) 127 (28). Anal. (Cι 6 Hι 4 CIFN 2 -HCI) C, H, N. EXAMPLE 13 (method g) N-benzyl-N-methyl-2-[5-chloro-1 -(4-fluorophenyl)-3-1 H-indolyl]ethylamine (14a) To a solution of 5-chloroindole (20 g, 0.13 mol) in dry diethyl ether (200 mL) was added a solution of oxalylchloride (20 g, 0.16 mol) in dry diehtyl ether (200 mL) at 0- 5 °C. After stirring for 0.5 h at 0-5 °C was added a solution of benzylmethylamine (24 g, 0.20 mol) in dry diethyl ether at 0-5 °C and triethylamine was slowly added to pH at 8-9. Water and ethyl acetate (500 mL) was added and the organic phase was washed with brine and dried (Na2Sθ4). Evaporation of the solvents afforded the crude N -benzyl-N-methyl-2-(5-chloro-1-(4-fluorophenyl)-3-1 H-indolyl)-2-oxoacet- amide (19.1 g) as an oil. A solution of the crude Λ/-benzyl-Λ/-methyl-2-(5-chloro-1-(4- fluorophenyl)-3-1 H-indolyl)-2-oxoacetamide (20.1 g, 0.058 mol) in dry tetrahydrofu- ran (200 mL) was added to a suspension of lithium aluminium hydride (5.4 g, 0.14 mol) in tetrahydrofuran (100 mL). After heating at reflux for 2.5 h the reaction mixture was cooled to 0 °C and treated with water (6 mL) and 4 N aqueous NaOH (6 mL). The precipitate was filtered off and extracted with dichloromethane (3 X 200 mL). The combined organic phases were dried (Na2Sθ4) and the solvents were evaporated. The remaining oil was purified by column chromatography (eluted with ethyl acetate) affording N-benzyl-N-methyl-2-(5-chloro-3-1 H-indolyl)ethylamine (16 g) as an oil: 1 H NMR (CDCI 3 ) δ 2.30 (s, 3 H), 2.65-2.80 (m, 2 H), 2.85-3.00 (m, 2 H), 3.60 (s, 2 H), 6.95 (broad s, 1 H), 7.05-7.20 (m, 2 H), 7.15-7.35 (m, 5), 7.45 (broad s, 1 H), 8.35 (broad s, 1 H). A mixture of N-benzyl-Λ/-methyl-2-(5-chloro-3-1 H-indolyl)ethylamine (16 g , 0.054 mol), 4-fluoro-iodobenzene (14.3 g, 0.064 mol), K 2 C0 3 (11.1 g, 0.080 mol) and 1 - methyl-2-pyrrolidinone (200 mL) was heated at 165 °C for 8 h. After cooling to room temperature water (250 mL) was added and the thus formed mixture was extracted with diethyl ether (2 X 300 mL). The combined organic phases were washed with brine (3 X 500 mL) and dried (Na2S04). Evaporation of the solvent afforded an oil that was purified by column chromatography (eluted with ethyl acetate/heptane 1 :3) affording pure title compound as an oil: 13.7 g (26 %) 1 H NMR (CDCI 3 ) δ 2.35 (s, 3 H), 2.70-2.80 (m, 2 H), 2.90-3.00 (m, 2 H), 3.60 (s, 2 H), 7.05-7.40 (m, 12 H), 7.55 (broad s, 1 H). The following compounds were prepared in a similar way: NΛ/-Dimethyl-2-(5-chloro-1-(4-fluorophenyl)-3-1 H-indolyl)ethylamine maleate (14b): mp 170-172 °C (ethyl acetate); 1 H NMR (CDCI3) δ 2.90 (s, 6 H), 3.20-3.30 (m, 2 H), 3.30-3.45 (m, 2 H), 6.30 (s, 2 H), 7.15-7.30 (m, 4 H), 7.35 (d, 1 H), 7.40 (dd, 2 H), 7.60 (broad s, 1 H); MS (m/z) 317 (MH + , 1 1 ), 272 (72), 237 (46), 236 (27). Anal. (C 18 H 18 CIFN2-C 4 H4θ4) C, H, N. 5-chloro-1-(4-fluorophenyl)-3-(2-(4-morpholinyl)ethyl)-1 H-indole fumarate(14c): mp 191-193 °C (ethanol); 1 H NMR (DMSO-d 6 ) δ 2.60-2.70 (m, 4 H), 2.75-2.85 (m, 2 H), 2.90-3.00 (m, 2 H), 3.60 (m, 4 H), 6.65 (s, 2 H), 7.20 (broad d, 1 H), 7.35-7.50 (m, 3 H), 7.55 (s, 1 H), 7.60 (dd, 2 H), 7.75 (broad s, 1 H); MS (m/z) 359 (MH + , 3), 272 (77), 237 (14), 100 (100). Anal. (C20H2 0 CIFN2OO4H4O4) C, H, N. EXAMPLE 14 Λ/-methyl-2-(5-chloro-1-(4-fluorophenyl)-3-1 H-indolyl)ethylamine maleate (15a) A mixture of N-benzyl-N-methyl-2-[5-chloro-1-(4-fluorophenyl)-3-1 H-indolyl]ethyl- amine (14a) (13.7 g, 0.026 mol), methyl chloroformate (2.9 g, 0.031 ), K 2 C0 3 (4.2 g, 0.031 ) and 1 ,1 ,1 -trichloroethane (150 mL) was heated at reflux for 2 h and the precipitates was filtered off. Evaporation of the solvents afforded crude N-methyl-N- methoxycarbonyl-2-[5-chloro-1-(4-fluorophenyl)-3-1 H-indolyl]ethylamine (12.2 g) as an oil. A mixture of the crude Λ/-methoxycarbonyl-2-[5-chloro-1-(4-fluorophenyl)-3- 1 H-indolyl]ethylamine (12.2 g, 0.034) and 47 % hydrobromic acid (150 mL) was heated at reflux for 14 h. The reaction mixture was poured into ice, made alkaline with concentrated NaOH and extracted with diethyl ether (2 X 200 mL). The combined organic phases were washed with brine and dried (Na 2 S0 4 ). Evaporation of the solvents afforded pure title compound as an oil (7.9 g, 52 %) which was crystalized as its maleate from ethyl acetate: mp 171-173 °C (ethyl acetate); 1 H NMR (DMSO-d 6 ) δ 2.65 (s, 3 H), 3.05-3.20 (m, 2 H), 3.20-3.30 (m, 2 H), 6.05 (s, 2 H), 7.20 (broad d, 1 H), 7.45 (t, 2 H), 7.50 (s, 1 H), 7.60 (dd, 2 H), 7.65 (s, 1 H), 7.80 (broad s, 1 H); MS (m/z) 303 (MH + ), 237 (82) 236 (100). Anal. (C 17 H 16 FCIN 2-C 4 H 4 θ4) C, H, N. EXAMPLE 15 (method g) Λ/,Λ/-Dimethyl-2-[5-bromo-1-(4-fluorophenyl)-1 H-indol-3-yloxy]ethylamine, hydro- chloride (16a) The starting material 5-bromo-1-(4-fluorophenyl)-3-hydroxy-1 H-indole-2-carboxylic acid methyl ester was prepared according to literature procedures (Unangst et al. J.Heterocyc.Chem. 1984, 21. 709-714 and J.Heterocyc.Chem. 1987, 811-815.). To a solution of this methyl ester (36 g) in acetone (250 mL) was added anh. potas¬ sium carbonate (20 g). The mixture was heated to reflux temperatures and a solution of 1-chloro-N,N-dimethylacetamide (15 g) in acetone (30 ml) was added dropwise during 25 minutes. The mixture was further refluxed for 2 hours. After cooling the mixture was worked up as above leaving 45 g of the crude N,N- dimethylacetamide derivative as an visceous oil which was used without further purification. To a solution of N,N-dimethyl-1-[5-bromo-1-(4-fluorophenyl)-2-methoxy- carbonylo-1 H-indol-3-yloxy]acetamide (44 g) in methanol was added an aqueous solution (50 ml) of potassium hydroxide (11 g). After reflux for 2 hours the precipi¬ tated potassium salt was filtered off and subsequently dissolved in water. pH was adjusted to <1 by addition of diluted hydrochloric acid. The precipitated carboxylic acid was filtered off, washed with water and finally dried in vacuo. Yield : 36 g. Mp : 146-150 °C. To a solution of the thus isolated N,N-dimethyl-1-[5-bromo-2-carboxy- 1-(4-fluorophenyl)-1 H-indol-3-yloxy]acetamide (10 g) in NMP (100 mL) was added Cu powder (1 g). The mixture was heated at 185-190 °C for 16 hours. After cooling to room temperature precipitates were filtered off and ethyl acetate, water and diluted aqueous NH4OH were added (pH > 10). The organic phase was separated and worked up as above leaving the crude product as an oil. Pure N,N-dimethyl-1- [5-bromo-1-(4-fluorophenyl)-1 H-indol-3-yloxy]acetamide (5 g) was obtained by column chromatography. All of the thus isolated acetamide derivative was dissolved in diethyl ether and added dropwise to a suspension of lithium aluminium hydride (1 g) in diethyl ether at reflux temperature. After reflux for 3 hours the mixture was cooled to 10 °C and water (1 mL) and diluted aqueous NaOH solution (2 mL) were added cautiously. The precipitated inorganic salts were filtered off and the filter cake was washed carefully with dichloromethane (2 x 50 mL). The combined organic phases were dried (anh. MgSθ4) and the solvents were evaporated in vacuo leaving the crude title compound as an oil (3 g). The crude product was dissolved in acetone and upon addition of an ether solution of HCI, the hydrochloric salt precipitated. Yield of 16a 2 g. Recrystallisation from 2-propanol gave a pure product with mp 189-190 °C. 1 H NMR (DMSO-d 6 ) δ 2.85 (s, 6H), 3.55 (t, 2H), 4.45 (t, 2H), 7.30 (dd, 1 H), 7.35-7.45 (m, 3H), 7.55 (s, 1 H), 7.60 (dd, 2H), 7.90 (d, 1 H), 10.95 (s, 1 H). MS (m/z) 377 (MH + ), 72 (100). Anal. (C 18 H 18 BrCIFN 2 -HCI) C, H, N. EXAMPLE 16 (method h) N,N-Dimethyl-2-[5-cyano-1 -(4-fluorophenyl)-1 H-indol-3-yloxy]ethylamine , hydro- chloride (17a) To a solution of N,N-dimethyl-2-[5-bromo-1-(4-fluorophenyl)-1 H-indol-3-yloxy]e- thylamine (4 g) prepared as in Example 1 1 in NMP (30 mL) was added CuCN (3 g). The mixture was heated at 160 °C for 9 hours. The mixture was poured into a solution of NaCN (5 g) in water (50 mL) while still hot. After stirring for 10 minutes ethyl acetate (2 x 50 mL) was added. The combined organic phase was worked up as above. The crude product was purified by column chromatography (eluent : ethyl acetate / ethanol / triethylamine : 90/10/4) on silica gel. Yield 1.5 g. The hydrochloric salt precipitated from acetone. Mp 221-223 °C. 1 H NMR (DMSO-d 6 ) δ 2.85 (s, 6H), 3.55 (t, 2H), 4.45 (t, 2H), 7.45 (t, 2H), 7.55-7.70 (m, 5H), 8.30 (s, 1 H), 10.85 (s, 1 H); MS (m/z) 324 (MH + ,2), 72 (100). Anal. (C 19 Hι 8 CIFN 3 -HCI)) C, H, N. Pharmacology The compounds of Formula I have been tested in established and reliable pharma¬ cological methods for determination of the activity at the 5-HT 2 receptor and the 5 dopamine D 2 receptor, respectively. The tests were as descibed in the following. Inhibition of 3 H-Ketanserin Binding To 5-HT 2 Receptors in Rat Cortex in vitro. By this method the inhibition by drugs of the binding of 3 H-Ketanserin (0,5 nM) to 5- HT 2 receptors in membranes from rat is determined in vitro. The method is descri- 10 bed in Hyttel, Pharmacol. & Toxicol. 61, 126-129, 1987. The results are shown in Table 1. Inhibition of 3 H-Spir operidol Binding to Dopamine D 2 Receptors in Rat Corpus Striatum in vitro 15 By this method the inhibition by drugs of the binding of 3 H-spiroperidol (0.5 nM) to dopamine D 2 receptors in membranes from rat corpus striatum is determined in vitro. The method is described in Hyttel & Larsen, J. Neurochem, 44 , 1615-1622, 1985). The results are shown in Table 1. 20 Quipazine Inhibition Quipazine is a 5-HT 2 agonist, which induces head twitches in rats. The test is a test for 5-HT 2 -antagonistic effect testing the ability to inhibit head twitches. The test is performed as published by Arnt et al. (Drug Development Research, 16, 59-70, 1989). 5 Antagonism of Pergolide-induced Circling Behaviour in Rats with Unilateral 6-OHDA Lesions This test, which is an extremely sensitive test for dopamine D-2 antagonism in vivo was performed as described in Arnt, J. and Hyttel J., Eur. J. Pharmacol. 102, 349- 30 354, 1984; and Arnt, J. and Hyttel J, J. Neural. Transm. 67, 225-240, 1986. Table 1 : RECEPTOR BINDING DATA (IC 50 values in nM) Compound No. 5-HT2 binding Dopamin D2 binding 3 H ketanserin 3 H spiroperidol 3a 19 42 3b 7.8 190 3c 310 26 3d 110 21 4a 4.2 2.9 4b 0.88 5.8 4c 18 18 4d 220 190 4e 5.9 2.3 4f 48 27 4h 2.0 200 4i 6.3 120 4j 17 63 4k 21 2.6 4n 28 4.7 4o 30 23 4p 35 17 4q 43 140 4r 86 770 4s 20 22 4u 1.0 19 4v 5.3 25 6a 7.4 5.5 6b 21 37 6c 42 330 7a 18 30 7b 8.2 18 8a 49 8.1 8b 220 35 9a 38 430 10 1 1 83 13a 12 19 13b 21 33 14b 8.9 38 14c 22 54 15a 17 24 16a 7.0 6.2 17a 21 0.98 Results It appears from Table 1 that the compounds of the invention are 5-HT 2 receptor ligands and many of them additionally D 2 receptor ligands in vitro. Furthermore, it was found in the Quipazine inhibition test that they are in general 5-HT 2 receptor antagonists in vivo. Furthermore, the test for inhibition of pergolide induced circling behaviour showed that many of the compounds are dopamine D 2 antagonists in vivo. Formulation Examples The pharmaceutical formulations of the invention may be prepared by conventional methods in the art. For example: Tablets may be prepared by mixing the active ingredient with ordinary adjuvants and/or diluents and subsequently compressing the mixture in a conven¬ tional tabletting machine. Examples of adjuvants or diluents comprise: corn starch, lactose, talcum, magne- sium stearate, gelatine, lactose, gums, and the like. Any other adjuvant or additive colourings, aroma, preservatives etc. may be used provided that they are compat¬ ible with the active ingredients. Solutions for injections may be prepared by solving the active ingredient and possible additives in a part of the vehicle, preferably sterile water, adjusting the solution to the desired volume, sterilization of the solution and filling in suitable ampules or vials. Any suitable additive conventionally used in the art may be added, such as tonicity agents, preservatives, antioxidants, etc. Typical examples of recipes for the formulations of the invention are as follows: 1) Tablets containing 5 milligrams of Compound 4h calculated as the free base: Compound 4h 5.0 mg Lactose 60 mg Maize starch 30 mg Hydroxypropylcellulose 2.4 mg Microcrystalline cellulose 19.2 mg Croscarmellose Sodium Type A 2.4 mg Magnesium stearate 0.84 mg 2) Tablets containing 1 milligram of Compound 4b calculated as the free base: Compound 4b 1.0 mg Lactose 46.9 mg Maize starch 23.5 mg Povidone 1.8 mg Microcrystalline cellulose 14.4 mg Croscarmellose Sodium Type A 1.8 mg Magnesium stearate 0.63 mg 3) Syrup containing per millilitre: Compound 10 5.0 mg Sorbitol 500 mg Hydroxypropylcellulose 15 mg Glycerol 50 mg Methyl-paraben 1 mg Propyl-paraben 0.1 mg Ethanol 0.005 mL Flavour 0.05 mg Saccharin natrium 0.5 mg Water ad 1 mL 4) Solution for injection containing per millilitre: Compound 3b 0.5 mg Sorbitol 5.1 mg Acetic acid 0.08 mg Water for injection ad 1 mL

Claims: CLAIMS 1. A novel 3-substituted 1-arylindole compound having general Formula I wherein Ar is selected from the group consisting of phenyl, 2-thienyl, 3-thienyl, 2- furyl, 3-furyl, 2-pyridyl, 3-pyridyl, and 4-pyridyl, and such groups substituted with one or more substituents selected from halogen, lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and cyano; X represents a bond or a divalent spacer selected from the group consisting of A-CR a R b and CR c R d , wherein A is O, S or CR e R f , and R a to R f are hydrogen, lower alkyl or lower alkenyl; the dotted line designates an optional bond; R 1 -R 4 are independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, nitro, lower alkylthio, lower alkylsulfonyl, lower alkyl- or dialkyiamino, cyano, trifluoromethyl, trifluoromethylsulfonyloxy and trifluoro- methylthio; R 5 is hydrogen, hydroxy, lower alkoxy, halogen, trifluoromethyl, lower alkyl optio¬ nally substituted with hydroxy or lower alkenyl optionally substituted with hydroxy; R 6 and R 7 independently represent hydrogen, lower alkyl or lower alkenyl; R 8 is lower alkyl, lower alkenyl or lower alkyl or lower alkenyl substituted with one or two hydroxy groups, or R 8 represents a group of Formula 1a or 1b : -(CH 2 )n- 1b. wherein n is an integer from 2 - 8; W is O or S; U is N or CH ; Z is (CH 2 ) m , rn being 2 or 3, 1 ,2-phenylene optionally substituted with halogen or trifluoromethyl, CH=CH, COCH 2 or CSCH2-; V is O, S, CH 2 , or NR 10 , wherein R 10 is hydrogen or lower alkyl, lower alkenyl, cyclo- alkyl or cycloalkyl-lower alkyl, each optionally substituted with one or two hydroxy groups; U 1 is O, S, CH 2 or a group NR 11 , wherein R 11 is selected among the R 10 -substitu- ents; and V I is NR 12 R 13 , OR 14 , SR 15 or CR 16 R 17 R 18 , where each of R 12 -R 18 may be indepen¬ dently selected among the R 10 -substituents; R 9 is hydrogen, lower alkyl, lower alkenyl or lower alkynyl; or R 9 is linked to R 7 in order to form a 5-6 membered ring containing one nitrogen atom; or R 8 and R 9 together with the nitrogen atom to which they are attached form a group of Formula 1c ,(CH 2 ) m / \ N Y wherein m is 1 or 2, Y is O, S or a group CH-R 19 where R 19 is hydrogen, or lower al¬ kyl or lower alkenyl, optionally substituted with one or two hydroxy groups; a group of Formula 1a or 1b as defined above; or a group CONR 20 R 21 , where R 20 and R 21 are hydrogen or lower alkyl, provided that Y may not be O or S when m is 1 ;and pharmaceutically acceptable salts thereof. 2. A compound according to Claim 1 , characterized in that Ar is phenyl or phenyl substituted with halogen. 3. A compound according to Claim 2, characterized in that Ar is 4-fluorophenyl. 4. A compound according to Claim 1 , characterized in that X is a bond or a group CR c R d , 0-CR a R b or CR e R f -CR a R b , preferably CR c R d , 0-CR a R b or CR e R f -CR a R , wherein R a to R f each represent hydrogen or lower alkyl, preferably hydrogen. 5. A compound according to Claim 4, characterized in that X is 0-CR a R b and R a and R b are hydrogen. 6. A compound according to Claim 1 , characterized in that and the dotted line designate a bond. 7. A compound according to Claim 1 , characterized in that R 1 and R 4 are 5 hydrogen, R 2 and R 3 are hydrogen, halogen, preferably fluoro or bromo, or cyano, R 5 is hydrogen, lower alkyl or lower alkyl substituted with hydroxy, and R 6 is hydrogen or lower alkyl. 8. A compound according to Claim 1 , characterized in that R 7 is hydrogen or ιo lower alkyl, preferably hydrogen or methyl, or R 7 is linked to R 9 in order to form a 5- 6 membered ring. 9. A compound according to Claim 1 , characterized in R 8 is preferably lower alkyl or a group of Formula 1a wherein n is 2, 3 or 4; W is O; U is N; V is NR 10 , 15 wherein R 10 is hydrogen, lower alkyl or lower alkenyl; and R 9 is hydrogen, lower alkyl or lower alkenyl; or R 9 is linked to R 7 in order to form a 5- or 6-membered ring, in particular a 5-membered ring, containing one nitrogen atom. 10. A compound according to Claim 1 , characterized in that R 8 and R 9 together 20 with the nitrogen atom to which they are attached form a group of Formula 1c wherein Y is O or a group CH-R 19 where R 19 is hydrogen or lower alkyl, or a group of Formula 1 a as defined in the preceeding paragraph, or a group CONR 20 R 21 , where R 20 and R 21 are hydrogen or lower alkyl. 25 11. A compound according to Claim 1 , characterized in that X is O-CH 2 , C H 2 -CH 2 , CH 2 or a bond; R 1 and R 4 are both hydrogen; R 2 and R 3 are independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, nitro, lower alkylthio, lower alkylsulfonyl, lower alkyl- or dialkyiamino, cyano, trifluoromethyl, trifluoromethylsulfonyloxy and trifluoromethyl- 30 thio; R 8 is a group of Formula 1a wherein n is 2, 3 or 4; W is O; U is N; V is NR 10 , wherein R 10 is hydrogen or lower alkyl; and R 9 is lower alkyl, preferably methyl. 12. A compound according to Claim 11 , characterized in that X is O-CH 2 , CH 2 -CH 2 or CH 2 ; and n is 2 or 3. 5 13. A compound according to Claim 11 or 1 2 , characterized in that R 3 is hydrogen. 14. A compound according to Claim 11 or 12, characterized in that R 3 is different from hydrogen. 10 15. A pharmaceutical composition characterized in that it comprises at least one novel compound according to Claim 1 together with a suitable pharmaceutically acceptable carrier or diluent. 15 16. Use of a novel compound according to Claim 1 for preparing a pharmaceutical composition for the treatment of anxiety, agression, depression, sleep disturbances, migraine, negative symptoms of schizophrenia, psychoses, extrapyramidal side effects induced by conventional antipsychotics, abuse of drugs and substances of abuse or Parkinson ' s disease. 0

Inventors: ANDERSEN KIM, PERREGAARD JENS KRISTIAN, ANDERSEN, KIM, PERREGAARD, JENS, KRISTIAN
Applicants: ANDERSEN KIM, LUNDBECK & CO AS H, PERREGAARD JENS KRISTIAN, ANDERSEN, KIM, H. LUNDBECK A/S, PERREGAARD, JENS, KRISTIAN
Application year: 1994
Main classification: C07D403
IPC codes: A61K31, A61P25, A61P43, C07D209, C07D403