FUCOSYLATED GLYCOSIDES AS INHIBITORS OF BACTERIAL ADHERENCE

Abstract: Mono-, di-, tri- or oligosaccharide glycoside derivatives having at least one terminal group which is derived from L-fucose. The compounds are useful for therapy or prophylaxis in conditions involving infection by Heliobacter pylori of human gastric mucosa. Another object of the present invention is to provide a process for their preparation and pharmaceutical compositions.

Description: FUCOSYLATED GLYCOSIDES AS INHIBITORS OF BACTERIAL ADHERENCE FIELD OF THE INVENTION The present invention relates to the use of L-fucose-containing glycoside derivatives for the preparation of pharmaceutical compositions for the treatment or prophylaxis of conditions involving gastrointestinal infections by Helicobacter pylori , a method of treating such conditions using the derivatives, as well as novel glycoside derivatives. BACKGROUND OF THE INVENTION Helicobacter pylori is a microaerophilic spiral shaped organism (originally assigned to the genus Campylobacter) which is found in the stomach and generally appears to have an exclusive habitat in the human gastric mucosa. It has been estimated that this bacterium infects the gastric mucosa of more than 60% of adu^ humans by the time they are 60 years old. Moreover, H. pyl i has been implicated as a contributing factor in a number of pathological conditions, including acute (type B) gastritis, gastric and duodenal ulcers, atrophic gastritis, and gastric adenocarcino a. Tissue tropism of bacteria is partly governed by the ability of a bacterial strain to adjust to the local chem ical environment in its specific habitat. In addition,adherence is a necessary prerequisite for colonization in order to prevent removal from the new habitat, e.g. through peristalsis in the gastrointestinal tract. In mammals, bacteria adhere to proteins or glycoconjugates (glycosphingolipids, glycoproteins) on or in the vicinity of epithelial cell surfaces (mucus) , and a number of specific bacterial adhesin-protein and adhesin-carbohydrate interactions have been described in the literature. With respect to H. pylori , studies in model systems such as mouse adrenal Y-l cells (see D. G. Evans, D. J. , Jr. Evans, and SUBSTITUTESHEET D. Y. Graham, (1989) Infect . Imm n . 57, 2272-2278) have suggested that surface-associated flexible fibrillar structures that surround this bacterium function as adhesins or colonization factor antigens to mediate the binding of H. pylori to cellular sialic acid-containing glycoprotein receptors. SUMMARY OF THE INVENTION The invention concerns the use of mono-, di-, tri- or oligosaccharide glycoside derivatives having at least one terminal group Y, as defined below, derived from L-fucose, said derivatives being compounds of the general formula la, lb, Ic, Id, Ie or If Y-Z i - A-Z 2 -R A-Z 3 -B-Z 4 -R la lb Ic Id Ie A—Z^ 2 ~B— i3 ""C—Z^ —D—Z^g—E—Z^g—R If wherein Z 1# Z 2 , Z 3 , Z 4 , Z 5 , Zg, z 7 , z g , z 9 , z 10 , z 11# z 12 , z 13 , z 14 , Z 15 and Z 16 independently are O, S, CH 2 , or NR 25 , where R 25 is hydrogen, C 1 _ 4 -al yl, C 2 _ 24 -alkenyl, C 1- . 2 -alkylcarbonyl, or benzoyl optionally substituted with hydroxy, amino, C 1 _ -alkyl, C j ^-alkoxy, nitro, halogen, phenoxy, or mono- or di-halogen-C 1 ^-alkyl; SUBSTITUTESHEET wherein the wavy line in Y, A, B, C, D and E signifies a bond which is either in the α- or in the 3-configuration; R 1# R 2 , and R 3 each independently are H, halogen, azido, guanidinyl, branched or unbranched C 1 _2 4 -alkyl # C 2 _ 2 -alkenyl, C _ 2 -alkynyl, C 3 _ 8 -cycloalkyl, C 3 _ 8 -cycloalkyl-C 1 _ 24 -alkyl, or C 1- . 12 -alkoxy-C 1 _ 12 -alkyl group which is optionally substituted with hydroxy, amino, halogen, or oxo; aryl or aryl-C 1 _ 4 -alkyl optionally substituted in the aryl moiety with hydroxy, amino, C 1- -alkyl, C j ^-alkoxy, nitro, halogen, phenoxy, or mono- or di-halogen-C^-alkyl; tri(C 1- _ 4 -alkyl)silylethyl; oxo; a group =CRR 5 wherein R 4 and R 5 independently are H, or C^-alkyl; or a group io wherein X is O, S , NR 20 , or =N- , and R 10 is H, branched or unbranched C 1 _ 24 -alkyl , C 2 _ 24 -alkenyl , C 2 _ 24 -alkynyl , C 3 _ 8 -cycloalkyl , C 3- . 8 -cycloalkyl-C 1 _ 24 -alkyl, or C 1 _ 12 -alkoxy-C 1 _ 12 -alkyl group which is optionally substituted with hydroxy, amino, halogen, or oxo; aryl , aryl-C 1 _ 4 -alkyl , or heterocyclyl-C^-aikyl optionally substituted in the aryl or heterocyclyl moiety with hydroxy, amino, SUBSTITUTE SHEET C 1 _ 4 -alkyl, C 1 _ -alkoxy, nitro, halogen, phenoxy, or mono- or di-halogen-C 1 _ -alkyl; tri(C 1 _ alkyl)silylethyl; tri silyl; trifC i ^-alkylJsilylethoxymethyl; the acyl residue of a naturally occurring amino acid; C 1 _ 24 -alkylcarbonyl; C 2 _ 2 -alkenylcarbonyl; C 3 _ 8 -cycloalkyl-C 1 _ 2 -alkylcarbonyl; arylcarbonyl; or terpeny1; and R 20 is H, C 1 _ 24 -alkyl, C 2 _ 2 -alkenyl, C 1 _ 2 -alkylcarbonyl, or benzoyl or phthaloyl optionally substituted in the benzene ring with hydroxy, amino, C 1 _ 4 -alkyl, C 1 _ -alkoxy, nitro, halogen, phenoxy, or mono- or di-halogen-C 1 _ 4 -alkyl; R 1A ' R 2A' R 3A' R 4A' R 1B ' R 2B ' R 3B ' R 4B ' R 1C R 2C R 3C R 4C R 1D ' R 2D ' 3D ' R 4D ' R 1E » R 2E ' R 3E ' an< ^ 4E ea Ch independently is as defined for R lf R 2 , and R 3 above, or is a group of the formula VII YZ χ VII wherein Y and Z 1 are as defined above; with the provisos that one of R 1B , R 2B , R 3B , or R 4B is Z 3 , Z 5 , Z 8 or Z 12 , that one of R lc , R 2C , R 3C , or R 4C is Z 6 , Z 9 or Z 13 , that one of R 1D , R 2D , R 3D , or R 4D is Z 10 , or Z 14 , that one of R 1E» R 2E' R 3E» or R 4E is Z 15» tnat at least one and at the most five of R 1A , R 2A , R 3A , R 4A , R 1B , R 2B , R 3B , R 4B , R 1C R 2C R 3C 4C R 1D ' R 2D ' R 3D ' 4D ' 1E ' R 2E » R 3E ' and R 4E is a group of the formula VII, and that the configurations of the substituents R 1A , R 2A , R 3A , and R 4A CH 2 in A, the configurations of the substituents R 1B , R 2B , R 3B , and R 4B CH 2 in B, the configurations of the substituents R lc , R 2C , R 3C , and 4 c C 2 i R c > the configurations of the substituents R 1D , R 2D , R 3D , and R 4D CH 2 in D, and the configurations of the substituents R 1E , R 2E , R 3E , and R 4E CH in E independently are D-gluco, L-gluco, D-galacto, SUBSTITUTESHEET L-galacto, D-manno , L-manno, D-talo , L-talo, D-allo, L-allo, D-altro, L-altro, D-gulo, L-gulo, D-ido, or L-ido; R is a branched or unbranched C 1 _ 24 -alkyl, C 2 _ 24 -alkenyl, C 2 _ 24 -alkynyl, C 3 _ 8 -cycloalkyl, C 3 _ 8 -cycloalkyl-C 1 _ 2 -alkyl, C 1 _ 12 -alkoxy-C 1 _ 12 -alky1, C 1 _ 24 -alkylcarbonyl, C 2 _ 2 -alkenylcarbonyl, or C 3 _ 8 -cycloalkyl-C 1- _. 2 -alkylcarbonyl group which is optionally substituted with hydroxy, amino, halogen, or oxo; an aryl, aryl-C 1- . 4 -alkyl, arylcarbonyl or aryl-C 1 _ -alkylcarbonyl group optionally substituted in the aryl moiety with hydroxy, amino, C j ^-alkyl, C 1 _ -alkoxy, nitro, halogen, phenoxy, or mono- or di-halogen-C 1-4 -alkyl; terpenyl; trifC j ^-alkyl)silylethyl; heterocyclyl; heterocyclyl-C j ^-alkyl; or heterocyclyl-C 1 _ -alkylcarbonyl; a group of the formula II or Ila R 30 -( C H2>q-S(O) m -CH 2 CH 2 - II [R 30 -(CH 2 ) q -S(O) m -CH 2 ] 2 CH-CH 2 - Ila wherein R 30 is H, carboxy, C α _ 4 -alkoxycarbonyl, hydroxy, amino, or a matrix MA, q is an integer from 1 to 24, and m is 0 or 2; or a group of the formula III or Ilia Phe-S(0) m -CH 2 CH 2 - III [Phe-S(0) m -CH 2 ] 2 CH-CH 2 - Ilia wherein m is as defined above, and each Phe is phenyl optionally substituted with hydroxy, amino, C j ^-alkyl, C 1 _ 4 -alkoxy, nitro, halogen, phenoxy or mono- or di-halogen C^-alkyl; or phenyl-C 1 _ -alkyl optionally monosubstituted in the phenyl moiety SUBSTITUTESHEET with hydroxy, amino, C 1 _ 4 -alkyl, C 1 _ 4 -alkoxy, nitro, halogen, phenoxy, or mono- or di-halogen-C 1 _ -alkyl; a group of the formula IV R 40 CH 2 CH(CH 2 R 50 )CH 2 - IV wherein R 40 and R 50 independently are halogen; or a group Q-(Spacer) r -, where r is an integer 0 or 1, and Q is a matrix MA or a group -COO-MA; in therapy, especially for the treatment or prophylaxis in humans of conditions involving infection by Helicobacter pylori of human gastric mucosa. Another aspect of the invention relates to the use of said compounds for the preparation of pharmaceutical compositions for use against the above mentioned conditions. DETAILED DESCRIPTION OF THE INVENTION In the present context, the terms "C j ^-alkyl", "C 1-8 -alkyl" and "C 1 _ 2 -alkyl" as a separate group or as part of a group designates alkyl groups with 1-4, 1-8 or 1-24 carbon atoms which may be straight or branched such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert.butyl, dimethy1butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, hexadecyl, octadecyl, etc. In the carbon chain the definition M C 1- . 24 -alkyl M is used herein, but also shorter number of carbon atoms in the carbon chain is possible as ,, C 1 _ 8 -alkyl" or "C 1 _ 4 -alkyl M . The term M C 1 _ 4 -alkyl" is used herein when substituents are defined. The term M C 3 _ 8 -cycloalkyl M as a group or as part of a group designates a cyclic alkyl group with 3-8 carbon atoms such as SUBSTITUTESHEET cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, or cyclooctyl. The term "C 2 _ 2 -alkenyl" designates unsaturated alkyl groups with 2-24 carbon atoms which may be straight or branched, preferably straight, in which the double bond may be present anywhere in the chain, for example vinyl, 1-propenyl, 2-propenyl, hexenyl, decenyl, hexadecenyl, octadecenyl. The term "C 2- . 4 -alkynyl" designates an alkyl group with 2-24 carbon atoms and incorporating a triple bond, e.g. ethynyl, 1-propynyl, 2-propynyl, 2-butynyl etc. The term "halogen" designates Cl, Br, I and F, preferably F and Cl. The terms "C^-alkoxy" and "C 1 _ 24 -alkoxy n designate groups comprising an oxa function substituted with an alkyl group as defined above. The terms "aryl" and "aryloxy" , either as a separate group or as part of a group, designates phenyl or naphthyl, preferably phenyl . The term "aryl-amide" defines either aryl-NH-C (O) - e. g. anilids, or aryl-C (0) -NH- e. g. benzamide. The term "terpenyl moiety" designates groups derived from some of the various unsaturated hydrocarbon compounds generically known as the terpenes, namely the monoterpenes and the sesquiterpenes , as well as hydroxy or oxo derivatives thereof . Examples of such groups are myrcenyl , (-) -limonenyl , terpineloyl , (+) -α-pinenyl , geraniolyl , (-) -mentholyl , (-) -camphoryl, farnesolyl, /8-eudesmolyl, and manoolyl . In the present context, the term "oligosaccharide" designates an oligosaccharide containing 4-10 monosaccharide units, preferably 4-7 monosaccharide units, the monosaccharide units being selected from aldohexoses (i.e. D-glucose, L-glucose, D-galactose, L-galactose, D-mannose, L-mannose, D-talose, L-talose, D-allose, L-allose, D-altrose, L-altrose, D-gulose, L-gulose, D-idose, or L-idose) or their derivatives, where the oligosaccharide may be linear or branched with the proviso that SUBSTITUTESHEET there are no more than seven monosaccharide units in the longest chain in the oligosaccharide. As indicated above, the wavy lines on the carbon atoms neighbouring the ring oxygen atoms in groups Y, A, B, C, D, and E signify that the bonds in question which are glycosidic bonds have either the α- or the ^-configuration. It is clear that each of the bonds in question on a particular group Y, A, B, C, D, and E may assume the - or the 0-configuration independent of the corresponding bonds on the other groups. A mono- or di-halogen-C 1 _ 4 -alkyl group may be substituted in any position and if substituted with 2 halogen atoms, the halogen atoms may be the same or different. The term "heterocyclyl" designates a monocyclic 5- or 6-membered, or a fused bicyclic (each ring being 5- or 6-membered) , aromatic or partly or fully saturated heterocyclic group containing from one to four hetero atoms per ring, the heteroatoms being selected independently from O, S and N and bound either via a carbon atom or via a nitrogen atom. Typical but non-limiting examples of such groups may comprise pyrrolyl, pyrazolyl, pyridinyl, thienyl, thiazolyl, oxazolyl, imidazolyl, isoxazolyl, isothiazolyl, furyl, pyrazinyl, pyrimidinyl, pyridazinyl, 2H-l,3-oxazinyl, 4H-l,3-oxazinyl, 6H-l,3-oxazinyl, 2H-l,3-thiazinyl, 4H-l,3-thiazinyl, 6H-l,3-thiazinyl, lH-l,2,3-triazolyl, 2H-l,2,3-triazolyl, lH-l,2,4-triazolyl, 4H-l,2,4-triazolyl, indolyl, purinyl, piperidyl or piperidino, morpholinyl or morpholino, piperazinyl, tetrahydrofuryl, thiazolidinyl, oxazolidinyl, imidazolidinyl, isoxazolidinyl, isothiazolidinyl, pyrrolidinyl, lH-tetrazolyl, or 2H-tetrazolyl. The term "acyl residue of a naturally occurring amino acid" designates the acyl residue of the L-amino acids occurring in proteins in nature, e.g. alanyl, valyl, leucyl, isoleucyl, prolinyl, phenylalanyl, tryptophanyl, methionyl, glycyl, seryl, threonyl, cysteinyl, tyrosyl, asparagyl, glutamyl, lysyl, SUBSTITUTESHEET arginyl, histidyl and the acyl residues of aspartic acid and glutamic acid, the acyl residue referring both to the carboxy group next to the amino function as well as the carboxy group at the end of the respective side chains, preferably, however, the carboxy groups next to the amino functions. The term "sphingoid" refers to D-erythro-2-amino-l,3- octadecanediol, its homologs and stereoisomers and to hydroxy and unsaturated derivatives thereof, including ceramide (see further definitions in Journ. of Lipid Research, vol. 19, (1978), 617-631). The term "steroid" refers to well-known steroids as cholesterol, cortisone, hydrocortisone, corticosterone, betamethasone, prednosolone, prednisone etc. The t.erm * trix" as used herein and designated as "MA" signi f ies any organic or inorganic, polymeric or macromolecular stn .ure to which the aglycon part of the 0-, S-, C-, or N-gl„ cosidic compound of the formula la, lb, Ic, Id, Ie or If is attached either covalently or by e.g. hydrophobic interaction. Examples of such matrices are residues of proteins, glycoproteins, polypeptides, polysaccharides, liposomes, emulsions, plastic polymers and inorganic materials. Residues of proteins are preferably bonded through nucleophilic groups in he proteins, e.g. groups such as amino, hydroxy1 and mercapto groups. Proteins or polypeptides themselves may be any of a wide variety of substances, in particular biologically compatible proteins such as globulins, albumins such as human serum albumin (HSA) , bovine serum albumin (E A) or sheep serum albumin (SSA) , ovalbu in, fibrins, or "key-hole" limpet haemocyanin (KLH) , glycoproteins such as bovine or human whole casein or lectins, and the like. Other examples of such matrices are synthetic polymers where one or several amino acids are coupled to a polymer of defined size(s), e.g. polylysine or oligolysine. In the various proteins or polypeptides, the linkage to the remainder of the group R may be through amino groups or through carboxyl groups. SUBSTITUTESHEET The polysaccharides, to which the 0-, S-, C-, or N-glycosidic compounds are attached, may be any of a wide variety of polysaccharides. The aglycon part of the compound of formula la, lb, Ic, Id, Ie or If may be bonded through hydroxy1 groups on ordinary polysaccharides such as cellulose, sepharose, starch or glycogen, through amino groups on amino saccharides such as chitosane or aminated sepharose, and through mercapto groups of thio-modified polysaccharides. Liposomes may be any biocompatible, biodegradable microesicular system compose of one or several bilayers surrounding aqueous compartments, within which a variety of agents can be encapsulated: hydrophobic agents in the lipid bilayers and hydrophilic agents in the inner aqueous space. The physicochemical properties of the liposomes are mainly dependent on the lipid composition. Liposomes are composed of phospholipids, such as egg yolk phospholipids, soya phospholipids, synthetic phosphatidylcholine e.g dimyritoylphosphatidylcholine (DMPC) and/or dipalmtoylphosphartidylchlorine (DPPC) or purified phosphatidylcholines of vegetable origin or other lipids, such as galactolipids, sphingolipids or glycosphingolipids. Emulsions are heterogenous mixtures of two or more imiscible liquids. To stabilize these systems an emulsifier is added. The emulsifier is oriented at the interface of the imisible liquids and usually only one phase persist in dropted form. Emulsions fall into two general categories. The heterogenous system described by droplets of an organic liquid dispersed in a continuous water phase is called oil-in-water emulsion (o/w) . Alternatively, the heterogenous system described by droplets of water dispersed in a continuous oil phase is called water-in- oil emulsion (w/o) . Any vegetable oil such as soybean oil, safflower oil, sesame oil, peanut oil, cottonseed oil, borago oil, sunflower oil. SUBSTITUTESHEET corn oil, olive oil,- medium chain triglycerides (such as Miglyol R ) , or acetylated monoglycerides may be used as internal or continuous phase. Examples of plastics to which the aglycon part of the compounds t 5 of the formula la, lb, Ic, Id, Ie or If may be attached are animated latex, thiolated, aminated, or hydroxylated polystyrene, polyacrylamide and polyvinyl alcohol. Other possible carriers are beads and gels of carbohydrate origin or polymers where carbohydrates are used in combination with other 10 polymeric materials such as sephacryl. These gels are further substituted with groups such as amino, thiols, cyano, active esters and disulfides. The plastics in question may be in the form of e.g. beads or film. 15 Examples of inorganic material, to which the aglycon part of the compounds of the formula la, lb, Ic, Id, Ie or If may be attached are silicon oxide materials such as silica gel, zeolite, diatomaceous earth, or the surface of various glass or silica gel types such as thiolated or aminated glass, where the 20 silica gel or the glass may be in the form of e.g. beads. Another example of an inorganic material is aluminium oxide. Particularly preferred matrix MA is human serum albumin (HSA) , bovine serum albumin (BSA) and polyacrylamide (PAA) . 25 An interesting embodiment of the invention is when the compound of formula la, lb, Ic, Id, Ie or If comprises a matrix MA, said matrix incorporating a multiplicity (i.e. 2 or more, such as 2-100 when the matrix is a protein such as BSA or HSA, or 30 10-10,000 when the matrix is a polymer such as polyacrylamide) of moieties of the formula la, lb, Ic, Id, Ie and If. It is contemplated that the presence of several such moieties will substantially enhance the inhibiting effect of the entire compound due to a multivalency-effect thereof on the bacteria. )5 It is also possible that the presence of several moieties of the formula la, lb, Ic, Id, Ie and If may even lead to agglutination of the bacteria. SUBSTITUTESHEET When, in connection- with the definition of formulas la, lb, Ic, Id, Ie and If, it is stated that the configurations of the substituents R 1A , R 2A , R 3A , and R 4A CH 2 in A, the configurations of the " substituents R 1B , R 2B , R 3B , and R 4B CH 2 in B, the configurations of the substituents R 1C , R 2C , R 3C , and R C CH 2 in C, the configurations of the substituents R 1D , R 2D , R 3D , and R 4D CH 2 * n D ' and tne configurations of the substituents R 1E , R 2E ' R 3E » and R 4E H 2 * n E independently are D-gluco, L-gluco, D-galacto, L-galacto, D-manno, L-manno, D-talo, L-talo, D-allo, L-allo, D-altro, L-altro, D-gulo, L-gulo, D-ido, or L-ido, this is intended to mean that the stereochemical substitution patterns that can be assumed by the various R-groups or R-group-containing groups on the cyclic groups A, B, C, D and E correspond to the stereochemical patterns formed by the 2-, 3-, and 4-hydroxy groups and the 5-hydroxymethyl group in D-glucose, L-glucose, D-galactose, L-galactose, D-mannose, L-mannose, D-talose, L-talose, D-allose, L-allose, D-altrose, L-altrose, D-gulose, L-gulose, D-idose, or L-idose, respectively. It will be clear that the groups R lf R 2 , R 3 and CH 3 in the group Y are arranged in such a configuration to give a L-galacto-pyranosyl unit and that the group Y therefore is a L-fucose unit or a derivative thereof. In the compounds of the formula la, lb, Ic, Id, Ie or If, it is preferred that Z lf Z 2 , Z 3 , Z 4 , Z 5 , Z 6 , Z 7 , Z 8 , Z 9 , Z 10 , Z n , Z 12 , Z 13' Z 14' Z 15 and Z 16 are °* It is also preferred that at the most four, more preferably at the most three, in particular one or two of R 1A , R 2A , R 3A , R 4A , 1B' 2B' 3B' R 4B' R 1C 2C R 3C R 4C» 1D' 2D» 3D' R 4D' 1E' R 2E , R 3E , or R 4E i s a group of formula VII. It is also preferred that R 1A is a group VII in the α-configuration. SUBSTITUTESHEET It is also preferred that the configuration of R 1A , R 2A , R 3A and R 4A CH 2 i° A are D-galacto, A being in the 3-configuration. Particularly preferred compounds are those wherein R 1A is a group VII in the o-configuration and the configuration of R 1A , R 2A' R 3 A and R 4A C 2 * n A are D-galacto, A being in the 0-configuration, especially A is Fucαl-2Gal/3. It is also preferred that R 2B is Z 3 , Z 5 , Z 8 , or Z 12 , and the configuration of R 1B , R 2B , R 3B , and R 4B CH 2 in B are D-gluco, B being in the ,5-configuration. It is also preferred that R 1B is an acetamido group. Particularly preferred compounds are those wherein R 1A is a group VII in the α-configuration; the configuration of R 1A , R 2A* R 3A and R 4A CH 2 ^ n A are D-galacto, A being in the ,5-configuration; R 2B is Z 3 , Z 5 , Z 8 , or Z 1 ; and the configuration of R 1B , R B , R 3B , and R 4B CH 2 in B are D-gluco, B being in the ^-configuration and R 1B is an acetamido group. Especially interesting are those compounds in which the A-Z 3 -B is Fucαl-2Gal01-3GlcNAc3 or Fucol-2Gal3l-3(Fucαl-4)GlcNAq8, those compounds in which A-Z 5 -B-Z 6 -C is Fucαl-2Gal01-3GlcNAq8l-3Gal/S or Fucαl-2Gal/Sl-3(Fucαl-4)GlcNAc3l-3Gal/3, those compounds in which A-Z 8 -B-Z 9 -C-Z 10 -D is GalNAcαl-3 (Fucαl-2) Gal01-3 (Fucαl-4) GlcNAc3l-3Gal 3 or Fucαl-2Gal/3l-3 (Fucαl-4) GlcNAc01-3Gal01-4Glc/3and those compounds in which A-Z 12 -B-Z 13 -C-Z 14 -D-Z 15 -E is GalNAcαl-3 (Fucαl-2) Galj8l-3 (Fucαl-4 ) GlcNAc£l-3Gal 5l-4Glc/5. It is also preferred that R 3B is a group of the formula VII in the β-configuration. Particularly preferred compounds are those wherein the configurations of R 1A , R 2A , R 3A , and R 4A CH 2 in A and of R 1B , R 2B , R 3B , and R B CH 2 in B are D-galacto, and the configurations of SUBSTITUTESHEET R ic R 2 c R 3 c and R4c CH 2 ^ n c are D-gluco, A being in the α-configuration, and B and C being in the ^-configuration, and in which R 1B and R 3C are groups of the formula VII in the α-configuration, and in which R 1A and R lc are acetamido groups, and R 2B is Z 5 , Z 8 or Z 12 , and R 2C is Z 6 , Z 9 or Z 13 . An interesting class of compounds is that in which the carbohydrate moiety contains the structure Y-Z^A- where Z x is O and the L-fucose unit Y is linked to the 2-position of A. Examples of interesting basic carbohydrate structures in this class are those having the following formulae where the substituents R 2 , R 2 , R 3 , R 1A , R 2A , R 3A , and R 4A each are indicated as OH, although this is not to be construed as limiting the definitions of the R-substituents in this manner; rather, R 1# R 2 , R 3 , R 1A , R 2A , R 3A , and R A should be considered as being able to assume all the meanings defined above in connection with the formulae la, lb, Ic, Id, Ie and If. Thus, the structure Y-Z^A- may be Fucαl-2All,5l→ Fucαl-2AltjSl→ Fucαl-2GlcSl→ Fucαl-2ManSl→ Fucαl-2Gul01→ Fucαl-2IdoSl→ Fucαl-2Gal01→ Fucαl-2Tal01→ When the groups R 1# R 2 , R 3 , R^, R 2A , R 3A , R 4A , R 1B , R 2B , R 3B , 4B ' R 1C 2C ' R 3C R 4C R 1D ' R 2D ' R 3D ' R 4D » 1E ' R 2E ' 3E ' or R 4E in Y, A, B, C, D, and E are not hydroxyl, they may preferably be selected among the following: H, Cl, F, azido, guanidyl, methyl, ethyl, propyl, vinyl, allyl, prop-l-enyl, ethynyl, prop-2-ynyl, prop-1-ynyl, acetyl, cyclopropyl, cyclopropylmethyl, methoxymethyl, hydroxymethyl, phenyl, oxo, methylene, thiol, amino, methoxy, ethoxy, propoxy, butoxy, hexyloxy, decyloxy, tetradecyloxy, octadecyloxy, vinyloxy, allyloxy, 1-propen-l-yloxy, crotyloxy. SUBSTITUTESHEET 3-buten-l-yloxy, 2-hexen-l-yloxy, 5-hexen-l-yloxy, 5-decen-l-yloxy, 9-decer_ -1-yloxy, 11-tetradecen-l-yloxy, oleoyl, ethynyloxy, 2-propyn-l-yloxy, 1-propyn-l-yloxy, methylthio, methylamino, dimethylamino, cyclopropoxy, cyclopropylmethoxy, methoxymethoxy, phenoxy, benzyloxy, 2-furylmethoxy, 2-thienylmethoxy, 2-pyridylmethoxy, trimethylsilyloxy, trimethyIsilylethoxy, acetoxy, propionyloxy, butyryloxy, hexanoyloxy, decanoyloxy, tetradecanoyloxy, octadecanoyloxy, acetamido, N-methylacetamido, acetylthio, glycyloxy, or alanyloxy. Interesting examples of aglycon groups R are the following: Methyl, ethyl, propyl, isopropyl, butyl, sec.butyl, isobutyl, tert.butyl, pentyl, isopentyl, 2-methylbutyl, 1-methylbutyl, 1-ethylpropy1 , hexyl, isohexyl, 3-methylpentyl, 2-methylpentyl, 1-methylpentyl, 2-ethylbutyl, 1-ethylbutyl, heptyl, isoheptyl, 4-methylhexyl, 3-methylhexyl, 2-methylhexyl, 1-methylhexyl, 3-ethylpentyl, 2-ethylpentyl, 1-ethylpentyl, 1-propylbutyl, octyl, decyl, dodecyl, tetradecyl, hexadecyl, octadecyl, tetracosyl, cyclopropyl, cyclopropylethyl, cyclobutyl, cyclobutylmethyl, cyclopentylmethyl, cyclopentylprop-3-yl, cyclohexyl, cyclohexylmethyl, cyclohexylprop-3-yl, cycloheptyl, phenyl, 4-nitrophenyl, benzyl, 4-phenylprop-l-yl, 3-hexylthio-2-(hexylthio) ethylprop-1-yl , 3-hexylsulfonyl-2-(hexylsulfonyl)methylprop-1-yl , 3-decylthio-2-(decylthio)methylprop-1-yl , 3-decylsulfonyl-2-(decylsulfonyl)methylprop-l-yl, 8-amino-3,6-dioxaoct-l-yl, 1,3-dihydroxyprop-2-yl, l,3-diaminoprop-2-yl, 3-hydroxy-2-(hydroxymethyl)prop-l-yl, 2-phenylthioethyl or trimethylsilylethyl. In a group R comprising a matrix MA, the linkage between the matrix MA and the remainder of R may typically be through any of the spacers well known in the field of protein conjugates, cf. for example J.H. Pazur, Adv. Carbohydr. Chem. Bxochem . , Vol 39, (1980), 405-447; Y.C. Lee & R.T. Lee, "Glycoconjugates", Vol. 4 Part B, 57-83, Ed. Horowitz, Academic Press, N.Y. (1982) ; and G. Magnusson, FEMS Symposium, 215-228 (1986) . in SUBSTITUTESHEET the present context, the term "Spacer" is intended to mean a molecule moiety which links the active substance to a carrier. A spacer molecule is designed to have two different functionalities, each reacting specifically with another functionality, a linear moiety being placed between these two functionalities. By linking the active substance to a carrier via a Spacer, one makes the active substance more accessible, e.g. to H. pylori adhesins or colonization factor antigens. The Spacer can be defined as (W) v -S'-P', wherein S' is an C^^ alkyl, an C 2 _ 24 alkenyl, an C 1 _ 2 alkylaryl, an arylc 1 _ 24 alkyl an aryic 1 _ 24 alkylaryl, an C 1 _ 24 alkylarylC 1 _ 24 alkyl group which groups may be interrupted by carbonyl, thiocarbonyl, oxycarbonyl, carbonyloxy, carbonylamino, aminocarbonyl, aza, oxa or thia groups; an aryl group, an aryloxy, an C 1 _ 24 alkoxy, a polyethyleneglycol group, a steroid group, a sphingoid group; all groups may be substituted with carboxyl, C 1 _ alkylcarbonyl, amide, hydroxy, alkoxy, aryloxy, phenoxy; P' is NH-C(S), NH-C(O), C(O) , NH, C(S) , C(0)0, (0)C0, SO, S0 2 , so 3 , S0 4 , P0 3 , P0 4 ; W is NH-C(S), NH-C(O), C(O), C(S) , C(0)0, (O)CO, SO, S0 2 , S0 3 , S0 4 , P0 2 , P0 3 , P0 4 , with the proviso that when Z l t Z 2 , Z , Z 7 , Z or Z 16 are CH 2 then W cannot be P0 2 , with the proviso that when Z l t Z , Z , Z 7 , Z or Z 16 are O or S then W cannot be (O)CO, S0 4 or P0 4 , and with the proviso that when Z l t Z 2 , Z 4 , Z 7 , Z αl or Z 16 are NH then W cannot be NH-C(S) , NH-C(O), (O)CO, S0 , P0 4 ; and v is an integer 0 or 1. The atom of the sugar moiety which linkages to the spacer is selected among from the following: -0-, -S-, -NH-, -CH - preferably -0-. In the compounds of the formulas la, lb, Ic, Id, Ie and If, the various groups R carrying the matrix MA may themselves comprise the spacer and the linkage. Specific and typical examples of linkages are those formed through amino group- or keto group- SUBSTΓΓUTE SHEET containing matrices. ' - Such linkages between the spacer and the matrix may have the following general structures: -NH-C(S)-/rø- or -C(0)-irø-, or - H-C(O) - wherein the atoms marked bold and italic orginate from the given matrix. The number of structures of the formulas la, lb, Ic, Id, Ie or if on each matrix unit may be mono- or multivalent and may vary between 1 to 10,000, depending on the nature of the matrix. Below follow a non-limiting list of examples of spacers suitable between Q and the remainder of R spacer 1 spacer2 spacer3 spacer5 spacer4 In the list c spacers given above and below, the atoms marked in bold italics originate from the matrix in question. The vertical wavy lines on the left and right ends in the spacer above signify that there are bonds at the ends. As examples of compounds of the general formulas la, lb, Ic, Id, Ie or If comprising matrix moieties, the following may be mentioned: SUBSTITUTESHEET NH C-potyacrylamid* SUBSTITUTE SHEET SUBSTITUTE SHEET When - " " * ^— is used in the examples above , this has the meaning of mono- , di-, tri- or oligosaccharide as specified in the text, and m' is an integer 0-5 and p is an integer 0-13 . When the matrix above is exemplified by BSA, HSA and polyacrylamide (PAA) this can be any other protein or peptide or other matrix specified in the text. Specific examples of interesting compounds of the formula la , lb, Ic, Id, Ie or If are the following: Fucαl-2Gal01-0-propyl Fucαl-2Gal 3l-0-isopropyl Fucαl-2Gal Sl-0-butyl Fucαl-2Gal/8l-0-tert-butyl Fucαl-2Gal/5l-0-hexyl Fucαl-2Gal/8l-0-octyl Fucαl-2Gal/Sl-0-decyl Fucαl-2Gal/3l-0-tetradecyl Fucαl-2Gal/3l-0-octadecyl Fucα 1-2 Gal/3 l-O- (C 6 bissulf ide) Fucαl-2Gal Sl-0- (C 10 bissulf ide) Fucαl-2Gal Sl-0- (Cgbissulf one) Fucαl-2Gal/5l-0- (C 10 bissulf one) Fucαl-2Gal 3l-0- (8-amino-3 , 6-dioxaoct-l-yl) Fucαl-2Gal/3l-3GlcNAcSl-0-propyl Fucαl-2GaljSl-3GlcNAc|8l-0-isopropyl Fucαl-2Gal/3l-3GlcNAc01-0-butyl Fucαl-2Gal / 8l-3GlcNAc/3l-0-tert. butyl Fucαl-2Gal/ffl-3GlcNAc/3l-0-hexyl Fucαl-2Gal Sl-3GlcNAcSl-0-octyl Fucαl-2Galj8l-3GlcNAci8l-0-decyl Fucαl-2Galj8l-3GlcNAcj8l-0-tetradecyl Fucαl-2Gal 3l-3GlcNAcSl-0-octadecyl Fucαl-2Gal 3l-3GlcNAc3-l-0- (Cgbissulf ide) SUBSTITUTE SHEET Fucαl-2Gal 3l-3GlcNAc/3-l-0- (Cgbissulf one) Fucαl-2Gal|3l-3GlcNAc/3-l-0- (8-amino-3 , 6-dioxaoct-l-yl) Fucαl-2Gal/3l-3GlcSl-0-propyl Fucαl-2Gal/3l-3Glcj8l-0-isopropyl Fucαl-2Gal/3l-3Glc01-0-butyl Fucαl-2Galj3l-3Glcj3l-0-tert . butyl Fucαl-2Gal|3l-3GlcjSl-0-hexyl Fucαl-2Gal 3l-3Glc01-0-octyl Fucαl-2Gal/3l-3Glq8l-0-tetradecyl Fucαl-2Gal01-3Glc ?l-0-octadecyl Fucαl-2Gal 3l-3Glc)3l-0- (Cgbissulf ide) Fucαl-2Gal 3l-3Glc3l-0- (C g bissulf one) Fucαl-2Gal 3l-3GlcjSl-0- (8-amino-3 , 6-dioxaoctyl) wherein Cgbissulfide = 3-hexylthio-2-(hexylthio)methylprop-l-yl- C 10 bissulfide « 3-decylthio-2-(decylthio)methylprop-l-yl- C bissulfone = 3-hexylsulfonyl-2-(hexylsulfonyl)methylprop -l-yl- C 10 bissulfone = 3-decylthio-2-(decylthio)methylprop-l-yl- Further interesting compounds are: Fucαl-2Gal3l-0-Me Fucαl-3Glc3l-0-Me Fucαl-3GlcNAc3l-0-Me Fucαl-3GlcNAc01-Spacer 1-BSA Fucαl-3GlcNAc01-0 tetradecyl Fucαl-4GlcNAcj8l-0-Me Fucαl-4GlcNAc/3l-Spacer 2-polyacrylamide Fucαl-4GlcNAc01-0-tetradecyl Fucαl-4Gal|8l-0-Me Fucαl-6Gal3l-0-Me Fucαl-6Gal/3l-Spacer 2-polyacrylamide Fucαl-2GalSl-Spacer 2-polyacrylamide SUBSTITUTESHEET Fucαl-2Gal/Sl-Spacer 1-BSA Fucαl-2Galj8l-Spacer 1-HSA Fucαl-2Gal/3l-Spacer 4-BSA Fucαl-2Gal/Sl-Spacer 4-HSA Fucαl-2GaljSl-Spacer 5-polyacrylamide . Fucαl-2Galj8l-0-tetradecyl Fucαl-2Gal/Sl-3GlcNAci3l-Spacer 5-polyacrylamide Fucαl-2Gal01-3GlcNAcjSl-Spacer 4 -BSA Fucαl-2Gal01-3GlcNAc/Sl-Spacer 4 -HSA Fucαl-2Gal/3l-3GlcNAcj8l-Spacer 2 -polyacrylamide Fucαl-2Galjffl-3GlcNAc/Sl-Spacer 1-HSA Fucαl-2Gal/Sl-3GlcNAcj8l-Spacer 1-BSA Fucαl-2Gal/3l-3GlcNAc/3l-0-tetradecyl Fucαl-2Gal/Sl-3Glc3l-Spacer 1-HSA Fucαl-2Gal Sl-3Glc/3l-Spacer 1-BSA Fucαl-2Gal Sl-3Glc01-Spacer 4 -HSA Fucαl-2Galj8l-3Glc3l-Spacer 4-BSA Fucαl-2Gal 3l-3Glc3l-Spacer 2 -polyacrylamide Fucαl-2Gal 3i-3Glc/3l-Spacer 5 -polyacrylamide Fucαl-2Gal Sl-3 (Fucαl-4 ) Glc Sl-Spacer 1-HSA Fucαl-2Gal/5l-3 (Fucαl-4) Glc 3l-Spacer 1-BSA Fucαl-2Galj8l-3 (Fucαl-4) Glc/Sl-Spacer 4-HSA Fucαl-2Gal Sl-3 (Fucαl-4) Glc/3l-Spacer 4-BSA Fucαl-2Gal 3l-3 (Fucαl-4 ) Glc/Sl-Spacer 2-polyacrylamide Fucαl-2Gal 3l-3 (Fucαl-4) Glc/Sl-Spacer 5-polyacrylamide Fucαl-2Galj8l-3 (Fucαl-4) GlcNAc3l-3Gal01-Spacer 3-BSA Fucαl-2Gal01-3 (Fucαl-4) GlcNAcj8l-3Gal 3l-Spacer 2 -polyacrylamide Fucαl-2Gal/8l-3 (Fucαl-4) GlcNAc Sl-3Gal/Sl-Spacer 5-polyacrylamide Fucαl-2Gal01-3 (Fucαl-4) GlcNAcj8l-3Gal 3l-0-tetradecyl Fucαl-2Gal/Sl-4Glc3l-Spacer 1-BSA Fucαl-2Gal|8l-4Glcj8l-Spacer 2-polyacrylamide Fucαl-2Gal 3l-4Glc Sl-0-tetradecyl Gal Sl-4 (Fucαl-3 ) GlcNAcSl-Spacer 1-BSA Gal/3l-4 (Fucαl-3 ) GlcNAc3l-Spacer 2 -polyacrylamide Gal Sl-4 (Fucαl-3 ) GlcNAc/Sl-O-tetradecyl Fucαl-2Gal/3l-3GlcNAq8l-3Gal/5l-Spacer 3-BSA Fucαl-2Gal/8l-3GlcNAcj8l-3Gal Sl-Spacer 3-HSA Fucαl-2Gal/5l-3GlcNAc/3l-3Gal01-Spacer 5-polyacrylamide SUBSTITUTE SHEET Fucαl-2Gal/3l-3GlcNAc/3l-3Gal/3l-Spacer 1-HSA Fucαl-2Gal/3l-3 G lcNAc/Sl-3Gal/3l-Spacer 5-BSA Fucαl-2Gal/3l- 3G lcNAc/3l-3Gal01-Spacer 4-HSA Fucαl-2Gal/Sl-3GlcNAc01-3Gal/3l-Spacer 4 -BSA Fucαl-2Gal/3l-3GlcNAq8l-3Galj8l-Spacer 2 -polyacrylamide Fucαl-2Gal01-3 G lcNAc/3l-3Gal/3l-0-tetradecyl GalNAcαl-3 (Fucαl-2) 3Galj8l-3 (Fucαl-4 ) GlcNAc/3l-3Gal01-Spacer- 3 -BSA GalNAcαl-3 (Fucαl-2) 3Gal|8l-3 (Fucαl-4) GlcNAc/3l-3Gal/Sl-Spacer- 2 -polyacrylamide GalNAcαl-3 (Fucαl-2 ) 3Gal/3l-3 (Fucαl-4 ) GlcNAc 3l-3Gal/3l-0-tetra- decyl Fucαl-2Gal/3l-4 (Fucαl-3) Glc/3l-Spacer 1-BSA Fucαl-2Gal/3l-4 (Fucαl-3 ) Glc/Sl-Spacer 2 -polyacrylamide Fucαl-2Gal/3l-4 ( Fucαl-3 ) Glc/3l-0-tetradecyl Fucαl-2 ( 3-O-methyl) Gal/3l-0-tetradecyl Fucαl-2 (3-0-methyl) Gal/3l-Spacer 1-BSA Fucαl-2 (3-O-methyl) Galβl-Spacer 2-polyacrylamide Fucαl-2 ( 3-O-allyl) Gal01-Spacer 1-BSA Fucαl-2 (3-0-allyl) Gal/8l-Spacer 2 -polyacrylamide Fucαl-2 (3-O-allyl) GaljSl-O-tetradecyl Fucαl-2 (3-0-propyl) Gal/Sl-Spacer 1-HSA Fucαl-2 (3-0-propyl) Gal/3l-Spacer 1-BSA Fucαl-2 (3-0-propyl) Gal/3l-Spacer 2-polyacrylamide Fucαl-2 ( 3-0-propyl) Gal/Sl-Spacer 4 -HSA Fucαl-2 (3-0-propyl) Gal/3l-Spacer 4-BSA Fucαl-2 (3-O-propyl) Gal/Sl-Spacer 5-polyacrylamide Fucαl-2 (3-O-butyl) Gal01-Spacer 1-BSA Fucαl-2 (3-0-butyl) Gal ?l-Spacer 2-polyacrylamide Fucαl-2 (3-O-butyl) Galj3l-0-tetradecyl Fucαl-2 (3-O-methyl) Gal01-3GlcNAc/3l-Spacer 1-BSA Fucαl-2 (3-O-methyl) Gal/Sl-3GlcNAcj8l-Spacer 2-polyacrylamide Fucαl-2 (3-O-methyl) Gal,. i-3GlcNAc/3l-0-tetradecyl Fucαl-2 (3-O-allyl) Gal/8l-3GlcNAcβl-Spacer 1-BSA Fucαl-2 (3-O-allyl) Gal/3l-3GlcNAqSl-Spacer 2 -polyacrylamide Fucαl-2 (3-0-allyl) Gal 3l-3GlcNAc/3l-0-tetradecyl Fucαl-2 (3-O-propyl) Gal01-3GlcNac/3l-Spacer 1-HSA Fucαl-2 (3-0-propyl) Gal/Sl-3GlcNac/3l-Spacer 1-BSA SUBSTITUTE SHEET Fucαl-2 (3-0-propyl) Gal/3l-3GlcNac/3l-Spacer 2-polyacrylamide Fucαl-2 (3-0-propyl) Gal/3l-3GlcNac01-Spacer 4-HSA Fucαl-2 (3-0-propyl) Gal|3l-3GlcNac/5l-Spacer 4-BSA Fucαl-2 (3-0-propyl) Gal/3l-3GlcNac/3l-Spacer 5-polyacrylamide Fucαl-2 (3-0-butyl) Gal/3l-3GlcNAc|Sl-Spacer 1-BSA Fucαl-2 (3-0-butyl) Gal/Sl-3GlcNAc/3l-Spacer 2 -polyacrylamide Fucαl-2 (3-O-butyl) Gal/3l-3GlcNAcj8l-0-tetradecyl Fucαl-2 (3-O-propyl) Gal01-3 ( Fucαl-4 ) GlcNac/3l-Spacer 1-HSA Fucαl-2 ( 3 -0-propyl) Ga 1/31-3 (Fucαl-4) GlcNacj3l-Spacer 1-BSA Fucαl-2 (3-0-propyl) Gal/3l-3 (Fucαl-4) GlcNac/3l-Spacer 2- polyacrylamide Fucαl-2 (3-0-propyl) Gal/3l-3 (Fucαl-4 ) GlcNac/3l-Spacer 4-HSA Fucαl-2 (3-0-propyl) Gal/3l-3 (Fucαl-4) GlcNac/3l-Spacer 4-BSA Fucαl-2 (3-0-propyl) Gal/3l-3 (Fucαl-4) GlcNac/3l-Spacer 5- polyacrylamide Fucαl-2 (3-0-methyl) Gal/3l-4GlcNAc)3l-Spacer 1-BSA Fucαl-2 (3-0-methyl) Gal/3l-4GlcNAc/3l-Spacer 2 -polyacrylamide Fucαl-2 (3-O-methyl) Gal/3l-4GlcNAc/Sl-0-tetradecyl Fucαl-2 (3-O-allyl) Gal/3l-4GlcNAc/3l-Spacer 1-BSA Fucαl-2 (3-0-allyl) Galj8l-4GlcNAc/3l-Spacer 2 -polyacrylamide Fucαl-2 (3-O-allyl) Gal/Sl-4GlcNAc/3l-0-tetradecyl Fucαl-2 (3-O-butyl) Galj8l-4GlcNAcj8l-Spacer 1-BSA Fucαl-2 (3-O-butyl) Gal/3l-4GlcNAc|8l-Spacer 2 -polyacrylamide Fucαl-2 (3-O-butyl) Galj8l-4GlcNAc/5l-0-tetradecyl Fucαl-2 (3-0-methyl) Gal/3l-3Glcj8l-Spacer 1-BSA Fucαl-2 (3-0-methyl) Gal/3l-3Glcj3l-Spacer 2-polyacrylamide Fucαl-2 (3-O-methyl) Galj8l-3Glcj8l-0-tetradecyl Fucαl-2 (3-0-allyl) Gal/3l-3Glc/3l-Spacer 1-BSA Fucαl-2 (3-0-allyl)Gal/3l-3Glcj8l-Spacer 2 -polyacrylamide Fucαl-2 (3-0-allyl) Gal/3l-3Glc/3l-0-tetradecyl Fucαl-2 (3-0-butyl) Gal/3l-3Glc/3l-Spacer 1-BSA Fucαl-2 (3-0-butyl) Gal/3l-3Glc/3l-Spacer 2 -polyacrylamide Fucαl-2 (3-O-butyl) Gal/3l-3Glc/3l-0-tetradecyl Fucαl-2Gal/Sl-4GlcNAc/3l-Spacer 1-BSA Fucαl-2Gal/3l-4GlcNAcj8l-Spacer 2-polyacrylamide Fucαl-2Gal/3l-4GlcNAc/3l-0-tetradecyl Galαl-3 (Fucαl-2 ) GaljSl-Spacer 1-BSA Galαl-3 (Fucαl-2 ) Gal/3l-Spacer 2 -polyacrylamide SUBSTITUTE SHEET Galαl-3(Fucαl-2)GalSl-O-tetradecyl GalNAcαl-3(Fucαl-2)Gal/3l-4Glc/3l-Spacer 1-BSA GalNAcαl-3(Fucαl-2)Gal/3l-4Glc/3l-Spacer 2-polyacrylamide GalNAcαl-3(Fucαl-2)Gal/3l-4Glc/3l-0-tetradecyl Gal/8l-3(Fucαl-4)GlcNAc/3l-3Gal/3l-4Glc/3l-Spacer 1-BSA Gal/3l-3(Fucαl-4)GlcNAc/3l-3Gal/3l-4Glc/3l-Spacer 2-polyacrylamide Gal/3l-3(Fucαl-4)GlcNAc/3l-3Gal/3l-4Glc/3l-0-tetradecyl Gal/3l-3(Fucαl-4)GlcNAc/3l-Spacer 1-BSA Gal/Sl-3(Fucαl-4)GlcNAc/Sl-Spacer 2-polyacrylamide Gal/8l-3(Fucαl-4)GlcNAc/3l-0-tetradecyl In the present application, such as the list above, specific compounds or parts of compounds may be named or represented in a condensed form corresponding to the recommendations concerning nomenclature of glycoproteins, glycopeptides, and peptidoglycans made by the Joint Commission on Biochemical Nomenclature under the International Union of Pure and Applied Chemistry and the International Union of Biochemistry (cf. Pure & Applied Chem. , Vol. 60, No. 9, pp 1389-1394, 1988). In another aspect, the invention concerns a pharmaceutical composition comprising a compound of the formula la, lb, Ic, Id, Ie or If as defined above or a mixture thereof in combination with at least one anti-ulcer medicament, or with at least one antibacterially active compound, or mixtures thereof, as well as a pharmaceutically acceptable carrier. The term "anti-ulcer medicament" is intended to denote any substance or composition which is able to reduce or participate in red', sing gastrointestinal ulcerations, in particular ulcerations in the stomach or duodenum. Pharmaceutical compositions according to the invention containing such substances or compositions have the potential advantage of being able to provide a dual effect by on the one hand reducing the ulceration and on the other hand simultaneously lowering the degree of infection in the stomach by H. pylori by preventing or inhibiting the adhesion of the bacterium onto the gastric or duodenal mucosa, thereby further promoting the SUBSTITUTESHEET healing of an ulcer; Suitable types of anti-ulcer medicaments are gastric secretion inhibiting compounds (primarily acid secretion inhibiting compounds) and antacids. In a preferred aspect of the use according to the invention, the pharmaceutical composition prepared is adapted to be administered in combination with a preparation for standard therapy of gastritis or ulcus, such as preparations containing anti-ulcer or anti-gastritis medicaments, e.g. selected among gastric secretion inhibiting compounds such as omeprazole, cimetidine, ranitidine, lansoprazole, pantoprazole, sucralfate, famotidine, or nizatidine, or antacids such as magnesium hydroxide, aluminium hydroxide, calcium carbonate, sodium carbonate, sodium hydrogen carbonate, simethicone or aluminium magnesium hydroxide or a hydrate thereof (such as the onohydrate known as magaldrate) . In another preferred aspect of the use according to the invention, the pharmaceutical composition prepared is adapted to be administered in combination with a preparation for a course of therapy with an antibacterial agent, such as an antibacterial agent selected from those listed above, in particular preparations containing /3-lactam antibiotics such as amoxicillin, ampicillin, cephalothin, cefaclor or cefixime; or macrolides such as erythromycin, or clarithromycin; or tetracyclines such as tetracycline or doxycycline; or aminoglycosides such as gentamycin, kanamycin or amikacin; or quinolones such as norfloxacin, ciprofloxacin or enoxacin; or others such as metronidazole, nitrofurantoin or chloramphenicol; or preparations containing bismuth salts such as bismuth subcitrate, bismuth subsalicylate, bismuth subcarbonate, bismuth subnitrate or bismuth subgallate. In a further aspect, the invention concerns all novel compounds among those having the formula la, lb, Ic, Id, Ie or If defined above. SUBSTITUTESHEET The compounds of formula la, lb, Ic, Id, Ie or If can be prepared according to several general methods using monosaccharides or oligosaccharides as starting materials. Functional group transformations can be performed before or after the formation of glycoside bonds. To ensure transformations of the functional group in a certain position, the use of reactions which are regiospecific or the protection with protective groups may optionally be necessary. The protective groups can be removed or can form part of the compound in question. The compounds of the invention can e.g. be prepared as shown in the scheme below. In the scheme, although specific substituents or configuration may be shown, it is to be understood that to the extent that it is appropriate, the various groups shown may assume the full variability range as defined for the general formulae la, lb, Ic, Id, Ie, and If. SUBSTITUTESHEET MONOSACCHARIDES Step l Step 2 Step 3 SUBSTITUTE SHEET In the first step (step 1) a monosaccharide, e.g. L-fucose, D-galactose, D-glucose, 2-deoxy-2-phthalimido-D-glucose, 2-deoxy-2-phthalimido-D-galactose, D-mannose, is converted to a glycoside, with aglycons (Ra) , e.g. SEt, SPh, OTMSEt, O-allyl or OBn (known aglycons in the art) , to form the R a -glycoside derivative in such a way that the R a -glycoside is possible to transform to a glycosyl donator by activation of the anomeric centre. The Ra-glycosides can be prepared as follows: A monosaccharide as above is per-O-acylated with acetic anhydride in pyridine or with acetic anhydride-sodium acetate or with benzoyl chloride in pyridine. The monosaccharide per-O-acylate is reacted with, e.g. hydrogen bromide or hydrogen chloride in a suitable solvent such as, e.g. acetic acid or dichloromethane, to form per-O-acylated glycosyl bromide or chloride (e.g. on O-acylation and glycosyl halide synthesis, see M. L. Wolfro and A. Thompson, Methods in Carbohydrate Chemistry, Vol. 2, 211-215, edited by R. L. Whistler and M. L. Wolfrom, Academic Press, New York, 1963, G. Hewit and G. Fletcher Jr., ibid, 226-228, and R. U. Lemieux, iJid, 223-224). The aglycon (Ra) is transferred to the monosaccharide by reacting a suitable thiol or alcohol, e.g. HSEt, HSPh, HOTMSEt, HO-allyl, or HOBn with the monosaccharide per-O-acylate using a Lewis acid such as boron trifluoride etherate (see e.g. R. J. Ferrier and R. H. Furneaux, Carbohydr. Res . 52 (1976), 63-68, J. Dahmen, T. Frejd, G. Grδnberg, T. Lave, G. Magnusson, and G. Noori, Carbohydr. Res . 116 (1983), 303-307), or trimethylsilyl trifluoro ethanesulfonate (see T. Ogawa, K. Beppu, S. Nakabayashi, Carbohydr. Res . 93 (1981), C6-C9) as promoters. The reaction is carried out in a suitable solvent such as chloroform, dichloromethane and/or toluene. When the monosaccharide derivative in question is a per-O-acylated glycosyl bromide or chloride, promoters such as silver trifluoromethanesulfonate or mercury(II) salts (see e.g. H. Paulsen, Angew. Chem . Int . Ed. Engl . 21 (1982), 155-173) can be used, and the reactions are carried out in suitable solvents such as dichloromethane and/or toluene. The monosaccharide Ra-glycosides is obtained after de-O-acylation using sodium methoxide (see e.g. A. Thompson, M. L. Wolfrom, and E. Pascu, SUBSTITUTESHEET Methods in Carbohydrate Chemistry, Vol. 2, 215-220, edited by R. L. Whistler and M. L. Wolfrom, Academic Press, New York, 1963) in methanol or in methanol containing a co-solvent such as dichloromethane or tetrahydrofuran. In the second step (step 2) the monosaccharide Ra-glycoside is further derivatized. New functional groups (Rb) which will form part of the final product or act as protective groups during the subsequent glycosylation steps are introduced. Examples of functional group transformations are: OH-groups to ethers or esters (see e.g. Protective Groups in Organic Synthesis edited by T. W. Greene and P. G. M. Wuts, John Wiley ' Sons, Inc., New York, 1991), OH-groups to carbonates (see e.g. J. March, Advanced Organic Chemistry - Reaction Mechanisms, and Structure, 347, 3rd Ed., John Wiley & Sons, New York, 1985, and references cited herein) , reductive removal or OH-groups via halides, sulfonates or other routes (see e.g. J. March, Advanced Organic Chemistry - Reaction Mechanisms, and Structure , 389-392, 394, 3rd Ed., John Wiley & Sons, New York, 1985, and references cited herein, and H. H. Baer, Pure Appl . Chem . 61(7) (1989), 1217-1234, and references cited herein), OH-groups to halogen (see e.g. J. March, Advanced Organic Chemistry - Reaction Mechanisms, and Structure , 381-286, 3rd Ed., John Wiley & Sons, New York, 1985, and references cited herein), OH-groups to azido groups (see e.g. J. March, Advanced Organic Chemistry - Reaction Mechanisms, and Structure, 380, 3rd Ed., John Wiley & Sons, New York, 1985, and references cited herein, and H. H. Baer, Pure Appl . Chem . 61(7) (1989), 1217-1234, and references cited herein), OH-groups to amino groups via azides or other routes (see e.g. J. March, Advanced Organic Chemistry - Reaction Mechanisms, and Structure, 798-800. 1106, 3rd Ed., John Wiley & Sons, New York, 1985, and references cited herein, and H. H. Baer, Pure Appl . Chem . 61(7) (1989), 1217-1234, and references cited herein), OH groups to keto groups (oxo) (see e.g. J. March, Advanced Organic Chemistry - Reaction Mechanisms, and Structure, 1048-1120, 3rd Ed., John Wiley & Sons, New York, 1985, and references cited herein) . OH groups to exomethylene derivatives via keto groups SUBSTITUTESHEET or other routes (see e.g. J. March, Advanced Organic Chemistry - Reaction Mechanisms, and structure , 400-404, 407, 845-854, 3rd Ed., John Wiley & Sons, New York, 1985, and references cited herein) , OH groups to alkyl groups via exomethylene derivatives and subsequent hydrogenation or via other routes (see e.g. H. O. H. House, Modern Synthetic Reactions , 1-130, 2nd Ed., W. A. Benjamin, Inc., Menlo Park, CA. , 1972, and references cites herein, or J. Yoshimura, Adv. Carbohydr. Chem. Biochem. 42 (1984), 69-134), and exchange of OH groups for heterocyclic groups via different routes (see e.g. A. R. Katrizky, JfandJboo/c of Heterocyclic chemistry, Pergamon Press, Oxford, 1985) . In the third step (step 3), condensation of the Ra-glycosides substituted with functional groups (Rb) (protective groups known inn the art) from above are performed. For O-glycosidic linkages: One Ra-glycoside derivative is transformed to a glycosyl donor by activation at the anomeric centre, and reacted with another Ra-glycoside which has been transformed to a glycosyl acceptor by removing one or several protective groups (see e.g. H. Paulsen, Angew. Chem . Int . Ed. Engl . 21 (1982), 155-173, R. R. Schmidt, Angew. Chem. Int . Ed. Engl . 25 (1986), 212-235, P. Fttgedi, P. J. Garegg, H. Lδnn, and T. Norberg, Glycoconj . J. 4 (1987), 97-108, Protective Groups in Organic Synthesis edited by T. W. Greene and P G. M. Wuts, John Wiley & Sons, Inc., New York, 1991). For C-glycosidic linkages see e.g. R. R. Schmidt, and G. Effenberger, Liebigs Ann . Chem. (1987), 825-831, S. Czernecki, and G. Ville, J. Org. Chem . 54 (1989), 610-612, R. Preuss, and R. R. Schmidt, J. Carbohydr. Chem. 10(5) (1992), 887-900, O. Martin, and W. Lai, J. Org. Chem . 58 (1993), 176-185, or C. R. Bertozzi, P. D. Hoeprich, Jr., and M. D. Bednarski, J. Org. Chem . 57 (1992), 6092-6094. For S-glycosidic linkages see e.g. L-X Wang, N. Sakairi, and H. Kuzuhars, J. Chem. Soc. Perkin Trans . 1 (1990), 1677-1982, or M. Blanc-Meusser, L. Vigne, H. Driguez, J. Lehman, J. Streck, and K. Urbahns, CarJbohydr. Res . 224 (1982), 59-71. SUBSTITUTESHEET Further glycosidic linkages may be introduced by repeating the third step. In the fourth step (step 4) the substituent (R c ) at the reducing end is introduced. R c is defined as (Z 1 -Z 16 )-R , wherein R and Z^Z^ have the definition given for compounds la, lb, Ic, Id, Ie and If. The term " ( Z 1 -Z 16 ) -R n shall be read as Z x -R, Z 2 -R, Z 3 -R Z 16 -R. Activation of an oligosaccharide Ra-glycoside derivative from step 3 at the anomeric centre of the reducing end and reaction with a suitable nucleophile leads to 0-, C-, S-, or N-glycosidic derivatives, respectively. A final product is obtained after removal of protective groups, if necessary. When the compound of the invention is in the form of a conjugate with a particular matrix, the Rc-glycoside derivative is further transformed via different routes to the final product (see e.g. Y. G. Lee, and R. T. Lee, Glycoconjugates , 121-164, edited by H. J. Allen, and E. C. Kisailus, Dekker, New York, 1992, R. Roy, F. D. Tropper, and A. Romanowska, J. Soc , Chem . Commun . (1992), 1611-1613, or C. P. Sotwell and Y. C. Lee, Adv. Carbohydr. Chem. Biochem. , Vol. 37 (1980), 225-281). Copolymerisation reactions for preparation of copolymers of acrylamide and the mono-, di-, tri- or oligosaccharide glycosides with or without a spacer are performed by known methods, for example as described in E. Kallin, H. Lδnn, T. Norberg and M. Elofsson, J. Carbohydr. Chemistry 8(4), 597-611 (1989) or M. Andersson and S. Oscarsson, Bioconjugate Chemistry, vol. 4(3), 246-247 (1993). The general strategy for preparation of these conjugates has been to attach an olefinic group to a carbohydrate, and then copolymerize this derivative with acrylamide. The olefinic group has been introduced into the carbohydrate molecule either as an allyl glycoside at an early stage by acryloylation of an amino function of a mono-, di-, tri- or oligosaccharide derivative or by other known methods. SUBSTITUTESHEET As indicated above, pharmaceutical preparations containing the compounds of the general formula la, lb, Ic, Id, Ie or If constitute a further aspect of the invention. The compounds of the invention can be administered systemically or locally and are preferably administered orally or by injection, by the rectal route, by the transdermal route, by infusion or by inhalation in the form of a pharmaceutical preparation comprising the active ingredient in the form of the original compound or in the form of a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable carrier which may be a solid, semi-solid or liquid diluent or an ingestible capsule, and such preparations comprise a further aspect of the invention. Pharmaceutically acceptable carriers must, of course, be of sufficiently high purity and sufficiently low toxicity to render them suitable for administration to human or mammals being treated. The compounds may also be sed without carrier material. As examples of pharmaceutical preparations may be mentioned tablets, capsules, dragees, solutions, drops, such as nasal drops, aerosols for inhalation, nasal spray, liposomes, etc. Usually the active substance will comprise between 0.01 and 99 % by weight of the preparation, e.g. between 0.5 and 20% by weight for preparations intended for injection and between 0.1 and 50% by weight for preparations intended for oral administration. The preparations are preferably in unit dosage form, whether as single dosage units or as multiple dosage units. To produce pharmaceutical preparations in the form of dosage units for oral application containing a compound of the invention, the active ingredient may be mixed with conventionally used solids, pulverulent carriers, e.g. lactose, saccharose, sorbitol, mannitol, a starch such as potato starch, corn starch, amylopectin, laminaria powder or citrus pulp powder, a cellulose derivative or gelatine and also may include lubricants such as magnesium or calcium stearate or a Carbowax® SUBSTITUTESHEET -34- or other polyethylene glycol waxes and compressed to form tablets or cores for dragees. If dragees are required, the cores may be coated with e.g. concentrated sugar solutions which may contain gum arabic, talc and/or titanium dioxide, or , alternatively, with a film forming agent dissolved in easily volatile organic solvents or mixtures of organic solvents. Dyestuffs can be added to these coatings, e.g. to distinguish between different contents of active substance. For the preparation of soft gelatine capsules consisting of gelatine and, e.g. glycerol and a plasticizer, or similar closed capsules, the active substance may be admixed with a Carbowax® or a suitable oil such as e.g. sesame oil, olive oil, or arachis oil. Hard gelatine capsules may contain granulates of the active substance with solid, pulverulent carriers such as lactose, saccharose, sorbitol, mannitol, starches, e.g. potato starch or corn starch, or amylopectin, cellulose derivatives o gelatine, and may also include magnesium stearate or stearic acid as lubricants. The compositions of the invention may be formulated so as to provide quick, sustained or delayed release of the active ingredient after administration to the patient by employing procedures well known in the art. By using several layers of the active drug, separated by slowl dissolving coatings, sustained release tablets are obtained. Another way of preparing sustained release tablets is to divid the dose of the active drug into granules with coatings of different thickness and compress the granules into tablets together with the carrier substance. The active substance can also be incorporated in slowly dissolving tablets made of e.g. fat and wax substances or evenly distributed in a tablet of an insoluble substance such as a physiologically inert plastic substance. Liquid preparations for oral application may be in the form of elixirs, syrups or suspensions, e.g. solutions containing from SUBSTITUTESHEET about 0.1% to 20% by weight of the active substance, sugar and a mixture of ethanol, water, glycerol, propylene glycol and optionally aroma, saccharin and/or carboxymethylcellulose as dispersing agents. The formulations can additionally include wetting agent, emulsifying and suspending agents, preserving agents and sweetening agents. For parenteral application by injection, preparations may comprise an aqueous solution of the active drug or a physiologically acceptable salt thereof, desirably in a concentration of 0.5-20% and optionally also a stabilizing agent and/or buffer substances in aqueous solution. Dosage units of the solution may advantageously be enclosed in ampoules. There is limited knowledge of compounds that inhibit the adherence of Helicobacter pylori to mucosal surfaces such that the compounds are useful in the prevention or treatment of gastrointestinal disorders and diseases caused or mediated by Helicobacter pylori . Because of this limited knowledge, the dosage at which the active ingredients may be administered may vary within a wide range and will depend on various factors such as e.g. the severity of the infection, the age of the patient etc. and may have to be individually adjusted. The pharmaceutical compositions of the subject invention preferably contain from about 1 mg to about 50 g, more preferably from about 10 mg to about 5 g per day of the active ingredient and may be divided into multiple doses. The invention is further illustrated by the following, non-limiting examples. SUBSTITUTESHEET 3 R = OMe 1 R = SEt 6R= O-^^ 2 R = OMe 9R= ° ^ Λ 5R= °^ N, 8 R = 0. ^ N, 4 R = O e 7R= 0 -^ SUBSTITUTE SHEET R = - O ".. 13 R = 14 N^Si(CH 3 ) 3 ^^SitCHaJa O O OBz = O^^Ph NHAc = HN CH 3 OBn = OCH 2 Ph SUBSTITUTE SHEET 18 R = SEt 24 R= O, ^ SUBSTITUTE SHEET -39- 25 R, = Ac 27 R, = Bz. R 2 = -CH 2 CH 2 N 3 26 R, = Bz 28 R, = H. R 2 = -CH 2 CH 2 N 3 32 R, = Bz. R 2 = -(CH 2 CH 2 0) 2 CH 2 CH 2 N 3 33 R, = H. R 2 = -(CH 2 CH 2 0) 2 CH 2 CH 2 N 3 29 R, = Bn. R 2 = -CH 2 CH 2 N 3 30 R, = H. R 2 = -CH 2 CH 2 NH 2 57 R, = H, R 2 = -CH 2 CH 2 NHCOCH 2 34 R, = Bn. R 2 = -(CH 2 CH 2 0) 2 CH 2 CH 2 N 3 35 R, = H. R 2 = -(CH 2 CH 2 0) 2 CH 2 CH 2 NH 2 37 R, = H. R 2 = -(CH 2 CH 2 0) 2 CH 2 CH 2 NHCOCHCH 2 31 36 SUBSTITUTE SHEET 43 44 R, = Ac R 2 = NPhth NPhth = £0 45 R, = OH R 2 u NHAc 46 R, = Bn R 2 = N 3 R 3 = CHPh 47 R, = Bn R 2 = NHCOCF 3 R 3 = CHPh 48 R, = H R 2 = NHCOCF 3 R 3 = H 49 R, = H R 2 = NHCOCHCH 2 R 3 = H SUBSTITUTE SHEET 45 R, = H R 2 = NHAc R 3 . R 4 = CHPh 51 R,=H R 2 = NHAc R 4 = H R 3 =OBn R, = Bn R 2 = N 3 R 4 = Bn R, = Bn R 2 = NHCOCF 3 FU =Bn R, =H R 2 = NHCOCF 3 R 4 > H R, = H R 2 = NHCOCH 2 R 4 = H SUBSTITUTE SHEET -42- R, = OH R, = NH 2 R, = NHCOCHCHg SUBSTITUTE SHEET General methods ~R and 13 C NMR spectra in examples 1 to 6 were recorded on a Varian Gemini 300 spectrometer and on a Varian Unity 400 MHz spectrometer. In examples 1 to 6 the following reference signals were used: CHC1 3 , δ 7.25 (~R in CDC1 3 ) ; CHC1 3 , δ 77.9 ( 13 C in CDC1 3 ); (CH 3 ) 2 CO, δ 2.24 or CHD 2 OH δ 3.31 ( ~ H in D 2 0) ; (CH 3 ) 2 CO, δ 33.19 or CHD 2 OH, δ 51.89 ( 13 C in D 2 0) ; CHD 2 0H, δ 3.31 (~R in CD 3 OD) . -R and 13 C NMR spectra in all other examples were recorded at 25 β C in CDC1 3 (using tetramethylsilane as internal standard for ~ R, CDC1 3 δ 77.0 for 13 C) and in D 0 (HDO δ 4.765 for ~R, using aceton δ 30.0 as internal standard for 13 C) . NMR spectra recorded for all compounds were in agreement with the structures postulated and only selected data are reported. Masspectra to determine the degree of substitution of carbohydrate component vs. protein were performed on a VG TOFSPEC linear time of flight masspectrometer. Fab-MS was run on a Nermag 1010L, with an lontech FAB gun and a matrix of thioglycerol. Optical rotations were measured using a Perkin Elmer 241 polarimeter. Thin layer chromatography (TLC) was performed on Merck DC-Fertigplatten (Kiselgel 60 F254 0.25 mm) and spots were visualized by UV or by spraying with 10% sulphuric acid followed by charring at elevated temperature, or by spraying with phospohomolybdic acid or ninhydrin in n-butanol (0.5%). Silica gel 60 (40-63 λm) and Amicon Matrex® Silica Si 0.35-0.70 m was used for column chromatography. Separations were also performed on a Chromatotron* rotary TLC using 1-2 mm layers of Silica Gel 60 PF 254 with gipsu . All Biogel* P-2 column were eluated with 1% n-buthanol in deionized water if not otherwise stated. EXAMPLE 1 Methyl 2-acetamido-2-deoxy-3-O-a-L-fucopyranosyl-0-D- glucopyranoside (4) SUBSTITUTE SHEET (i) Methyl 4, 6 - 0 -benzylidene-3-0-(tri-0-benzyl- α-L-fucopyranosyl ) -2-deoxy-2-phthalimido-3-D-glucopyranoside (2) Trifluoromethanesulfonic acid (2 μl, 0.023 mmol) was added to a stirred mixture of ethyl 3-0-(tri-0-benzyl-α-L- fucopyranosyl)-4,6-0-benzylidene-2-deoxy-2- phthalimido-1-thio- j S-D-glucopyranoside (1) (100 mg, 0.117 mmol), (prepared according to H. Lδnn, Carbohydr. Res . 139 (1985), 105-113) methanol (7 μl, 0.175 mmol), N-iodosuccinimide (40 mg, 0.175 mmol) and ground molecular sieves (100 mg, 3A) in dichloromethane-diethyl ether (3 ml, 2:1) at -30 β C. After 45 min the reaction mixture was filtered through a layer of Celite into an aqueous solution of sodium hydrogen carbonate and sodium bisulphite. The organic layer was separated, washed with aqueous sodium chloride, and concentrated. Column chromatography (toluene-ethyl acetate, 20:1) of the residue gave amorphous (2) (93 mg, 97 %) , [α] D -16.2° (c 1.0, CHC1 3 ) . -R NMR data (CDC1 3 , δ) : 7.80 to 7.00 (24H, benzyl and phthaloyl), 5.29 (d, IH, J 8.6 Hz, H-l) , 4.84 to 4.25 (5H, CH 2 Ph), 4.84 (bs, IH, H-l'), 4-66 ( * d » 1H » J 8 * 5 and 10 * 3 Hz ' H-3), 4.48 to 4.43 (m, IH, H-3'), 4.35 (dd, IH, J 8.6 and 10.3 HZ, H-2), 4.08 (bdd, IH, J 6.4 and 13.0 Hz, H-5'), 3.91 to 3.81 (2H), 3.78 to 3.66 (4H) , 3.51 to 3.47 (IH) , 3.48 (s, 3H, OCH 3 ) , 0.90 (d, 3H, CH 3 ). 13 C NMR data (CDC1 3 , δ) : 168.0 (CO), 138.8 to 123.0 (benzyl), 101.1 (CHPh), 99.7 (C-l'), 99.4 (C-l) , 82.1, 79.5, 78.0, 75.7, 75.5, 74.6, 73.0, 72.5, 68.6, 67.2 (C-5'), 66.1, 56.9 (OCH 3 ) , 55.5 (C-2), 16.3 (CH 3 ) . (ii) Methyl 2-acetamido-3-0-(2,3,4-tri-0-benzyl-α-L- fucopyranosyl)-4,6-0-benzylidene-2-deoxy-/3-D-glucopyranoside (3) A solution of (2) (1.13 g, 1.36 mmol) and hydrazine hydrate (3. 3 ml, 6 8 mmol) in aqueous 95% ethanol was boiled under SUBSTITUTESHEET reflux for 20 h, cooled, and concentrated. The residue was acetylated with acetic anhydride-pyridine (50 ml, 1:1) overnight. The solution was concentrated, and the residue was subjected to column chromatography (heptane-ethyl acetate, 1:1) to give crude (3) which was used directly in the next step. -R NMR data (CDC1 3 , δ) : 7.50 to 7.25 (20H, benzyl), 5.71 (d, IH, J 7.4, NH) , 5.52 (s, IH, CH 2 Ph) , 5.09 (d, IH, H-l'), 4.85 to 4.58 (6H, CH 2 Ph), 4.82 (d, IH, H-l), 4.37 )dd, IH, J 4.6 and 10.4 Hz, H-6) , 4.28 (bt, IH, H-3) , 4.12 to 4.05 (2H, H-2' and H-5'), 3.95 (dd, IH, J 2.6 and 10.2 Hz, H-3'), 3.78 (bt, IH, H-6), 3.63 (bs, IH, H-4'=, 3.60 (bt, IH, H-4) , 3.53 (m, IH, H-5) , 3.48 (s, 3H, OCH 3 ) , 3.42 (ddd, IH, J 7.2, 8.2 and 9.5 Hz, H-2), 1.67 (s, 3H, NHAC), 0.84 (d, 3H, CH 3 ) . 13 C NMR data (CDC1 3 , δ) : 170.6 (CO), 138.6 to 126.2 (benzyl), 101.8 (C-l), 101.6 (CHPh), 98.4 (C-l'), 80.8 (C-4) , 79.8 (C-3'), 77.6 (C-4'), 77.0 (C-2' or C-5'), 75.1 (C-3) , 74.9 (CH 2 Ph) , 72.5 (CH 2 Ph), 68.8 (C-6) , 66.9 (C-2' or C-5'), 66.2 (C-5), 58.1 (C-2), 57.0 (OCH 3 ) , 23.2 (NHAc) , 16.3 (CH 3 ) . (iii) Methyl 2-acetamido-2-deojcy-3-0-α-L-fucopyranosyl-/3-D- glucopyranoside (4) A solution of crude (3) (1.05 g) in acetic acid-ethyl acetate- water (9:5:1, 120 ml) was hydrogenolysed at 200 kPa over 10% Pd/C (1 g) over night. The mixture was filtered through a layer of Celite and concentrated. Column chromatography (chloroform- methanol-water, 65:35:6) of the residue gave amorphous 4 (469 mg, 90% calculated from (2), [cr] D -116.0 β (c 1.0, water). -R NMR data (D 2 0, acetone ref., δ) : 4.99 (d, IH, J 4.0 Hz, H-l'), 4.46 (d, IH, J 8.7 Hz, H-l), 4.33 (bdd, IH, H-5'), 3.98 to 3.45 (9H) , 3.51 (s, 3H, OCH 3 ) , 2.03 (s, 3H, NHAc), 1.17 )d, 3H, CH 3 ) . SUBSTITUTESHEET 13 C NMR data (D 2 0, acetone ref., δ) : 177.6 (CO), 104.7 (C-l), 102.9 (C-l'), 83.5, 78.8, 74.7, 72.5, 71.6, 70.9, 69.9, 63.7, 60.0, 59.1 (C-2), 25.2 (NHAc), 18.1 (CH 3 ) . EXAMPLE 2 3,3-Dimethylbutyl 2-acetamido-2-deoxy-3-0-α-L-fucopyranosyl-/S- D-glucopyranoside (7) (i) 3,3-Dimethylbutyl 3-0-(2,3,4-tri-0-benzyl-β-L- fucopyranosyl)-4,6-0-benzylidene-2-deoxy-2-phthalimido-/3-D- glucopyranoside (5) Trifluoromethanesulfonic acid (30 μl, 0.35 mmol) was added to a stirred mixture of (1), 3,3-dimethyl-butan-l-ol (317 μl, 2.62 mmol), N-iodosuccinimide (602 mg, 2.62 mmol), and ground molecular sieves (1.5 g, 3A) in dichloromethane-diethyl ether (2:1, 45 ml) at -30°C. After 45 min the reaction mixture was filtered through a layer of Celite into an aqueous solution of sodium hydrogen carbonate and sodium bisulphite. The organic layer was separated, washed with aqueous sodium chloride, and concentrated. Column chromatography (heptane-ethyl acetate, 6:1) of the residue gave amorphous (5) (1.42 g, 90%), [α] D -22.2 ~ (c 1.0, CHC1 3 ) . -R NMR data (CDC1 3 , δ) : 7.80 to 7.0 (24 H, benzyl and phthaloyl), 5.57 (s, IH, CHPh), 5.35 (d, IH, J 8.5 Hz, H-l), 4.84 (bs, IH, H-l'), 4.83 to 4.24 (5H, CH 2 Ph) , 4.65 (dd, IH, J 8.3 and 10 3 Hz, H-3) , 4.34 (dd, IH, J 8.5 and 10.4 Hz, H-2) , 4.07 (dd, IH, J 5.5 and 10.4 Hz, H-5'), 3.96 to 3.66 (7 H, inter alia OCH 2 ) , 3.53 to 3.45 (2H, inter alia OCH 2 ) , 1.46 to 1.29 (m, 2H, CH 2 C(CH 3 ) 3 ), 0.88 (d, 3H, J 6.4 Hz, CH 3 ) , 0.73 (s, 9H, CH 2 C(CH 3 ) 3 ). 13 C NMR data (CDC1 3 , δ) : 168.0 (CO), 138.8 to 123.0 (benzyl and phthaloyl), 101.1 (CHPh), 99.4 (C-l'), 98.9 (C-l), 82.1, 79.5, 76.0, 75.7 (C-3), 75.6, 74.6, 73.0, 72.6, 68.7, 67.3 (OCH 2 ) , SUBSTITUTESHEET 67 . 2 (C-5 ) , 66. 2 , 55. 8 (C-2 ) , 42 . 4 (CH 2 C ( CH 3 ) 3 ) , 30. 8 (CH 2 C (CH 3 ) 3 ) , 29 . 4 (CH 2 C (CH 3 ) 3 ) , 16 . 3 (CH 3 ) . (ii) 3,3-Dimethylbutyl 3-0-(2,3,4-tri-0-benzyl-o-L- fucopyranosyl)-2-acetamido-4,6-0-benzylidene-2-deoxy- /3-D-glucopyranoside (6) A solution of (5) (1.42 g, 1.58 mmol) and hydrazine hydrate (3.9 ml, 79 mmol) in aqueous 90% ethanol (100 ml) was boiled under reflux for 2 0 h, cooled, and concentrated. The residue was acetylated with acetic anhydride-pyridine (50 ml, 1:1) overnight. The solution was concentrated. Column chromatography (heptane-ethyl acetate, 3:1, containing 1% methanol) of the residue gave amorphous (6) (1.16 g, 90%), [α] D -74.7° (c 1.0, CHC1 3 ) . -R NMR data (CDC1 3 , δ) i 7.50 to 7.20 (20 H, benzyl), 5.63 (d, IH, J 7. 3 H Z , NH), 5.51 (S, IH, CH 2 Ph) , 5.07 (d, IH, J 3.1 Hz, H-l'). 4. 93 to 4.57 (6H, CH 2 Ph) , 4.92 (d, IH, H-l), 4.39 to 4.29 (2H, H-6 and H-3) , 4.11 to 4.04 (2H, H-2'and H-5'), 3.98 to 3.85 (2H, H-3'and 0CH 2 ) , 3.77 (bt, IH, H-6) , 3.61 (bs, IH, H-4'), 3.55 (bt, IH, H-4), 3.59 to 3.44 (2H, H-5 and 0CH 2 ) , 3.33 (bdd, IH, H-2) , 1.63 (s, 3H, OAc) , 1.56 to 1.40 (m, 2H, CH 2 C(CH 3 ) 3 ), 0.89 (S, 9H, CH 2 C(CH 3 ) 3 ), 0.82 (d, 3H, CH 3 ) . 13 C NMR data ( C DC1 3 , δ) : 170.4 (CO), 138.6 to 126.0 (benzyl), 101.6 ( C HPh), 100.7 (C-l), 98.1 (C-l'), 80.9 (C-4), 79.8 (C-3'), 77.6 (C-4'), 77.0 (C-2'or C-5'), 74.9 (C-3), 74.8 (CH 2 Ph), 74.0 (CH 2 Ph), 72.5 (CH 2 Ph) , 68.9 (0CH 2 or H-6) , 67.5 ( O CH 2 or H-6 ) , 66.8 (C-5' or C-2'), 66.2 (C-5), 58.6 (C-2), 42.7 (CH 2 C(CH 3 ) 3 ), 29.7 (CH 2 C(CH 3 ) 3 ) , 29.6 (C(CH 3 ) 3 ), 23.2 (NHAc), 16.2 (CH 3 ) . (iii) 3,3-Dimethylbutyl 2-acetamido-2-deoxy-3-0-α-L- fucopyranosyl- j S-D-glucopyranoside (7) A solution of the compound (6) (1.08 g, 1.33 mmol) in acetic acid:ethyl acetate:water, 9:5:1 (120mL) was hydrogenolysed at SUBSTITUTESHEET 200 kPa over 10% Palladium on charcoal (Pd/C) (1 g) over night. The mixture was filtered through a layer of Celite and concentrated. Column chromatography (chloroform-methanol-water, 100:30:3) of the residue gave amorphous (7) (566 mg, 94%), [α] D -109-7° (c 1.0, water). H NMR data (D 2 0, acetone ref., δ) : 4.99 (d, IH, H-l'), 4.84 (s, IH, CHPh), 4.34 (bdd, IH, H-5'), 4.02 to 3.43 (11H) , 2.01 (S, 3H, NHAC), 1.57 ti 1.41 (m, 2H, CH 2 C(CH 3 ) 3 ), 1.17 (d 3H, CH 3 ) , 0.90 (s, 9H, C(CH 3 ) 3 ). 13 C NMR data (D 2 0, acetone ref., δ) : 177.3 (CO), 103.6 (C-l), 102.8 (C-l'), 83.6, 78.8, 74.8, 72.5, 71.6, 70.9, 69.8, 63.7, 58.1 (C-2), 44.9 (CHC(CH 3 ) 3 ), 31.9 (C(CH 3 ) 3 ), 31.9 )C(CH 3 ) 3 ), 25.2 (NHAc), 18.1 (CH 3 ) . EXAMPLE 3 Fucαl-3GlcNAc3l-0-8pacer 1-BSA-conjugate (11) (i) 8-Azido-3,6-dioxaoctyl 3-0-(2,3,4-tri-0-benzyl-α-L- fucopyranosyl)-4,6-O-benzylidene-2-deojcy-2-phthalimido-0-D- glucopyranoside (8) Trifluoromethanesulfonic acid (24 μl, 0.27 mmol) was added to a stirred mixture of (1) (1.15 g, 1.34 mmol), 8-azido-3,6- dioxaoctan-1-ol (352 μl, 2.01 mmol) (prepared according to P. H. Amva -Zollo and P. Sinaϊ, Carbohydr. Res . 150 (1986), 199- 212), N-iodosuccinimide (461 mg, 2.01 mmol) and ground molecular sieves (1.15 g, 3A) in dichloromethane-diethyl ether (30 ml, 2:1) at -30 β C. After 1 h the reaction mixture was filtered through a layer of Celite into a aqueous solution of sodium hydrogen carbonate and sodium bisulphite. The organic layer was separated, washed with aqueous sodium chloride, and concentrated. Column chromatography (heptane-ethyl acetate, 2:1) of the residue gave amorphous (8) (1.03 g, 79%), [α]D -21-7° (c 1.0, CHC1 3 ). SUBSTITUTESHEET -R NMR data (CDC1 3 >. δ) : 7.80 to 7.05 (24H, Bzl, Phth) , 5.59 (s, IH, CHPh), 5.44 (d, IH, J 8.6 Hz, H-l), 4.83 (bs, IH, H-l'), 4.83 to 4.24 (5H, CH 2 Ph) , 4.65 (dd, IH, J 8.5 and 10.3 Hz, H-3), 4.45 to 4.41 (IH, H-3'), 4.39 (dd, IH, J 8.6 and 10.3 Hz, H-2), 4.09 (dd, IH, J 6.4 and 12.6 Hz, H-5'), 3.99 to 3.83 (3H, inter alia OCH 2 ) , 3.81 to 3.68 (5H, inter alia OCH 2 ) , 3.61 to 3.30 (11H, inter alia OCH 2 and CH 2 N 3 ) , 0.90 (d, 3H, J 6.4 Hz, CH 3 ). 13 C NMR data (CDC1 3 , δ) : 169.0 (CO), 138.9 to 123.1 (Bzl, Phth), 101.1 (CH 2 Ph), 99.4 (C-l'), 98.9 (C-l), 82.1, 79.6, 78.0, 75.6, 75.5, 74.7, 73.1, 72.6, 70.5, 70.4, 70.1, 69.9, 69.1, 68.7, 67.2, 66.2, 55.7 (C-2), 50.6 (CH 2 N 3 ) , 16.4 (CH 3 ) . (ii) 8-Azido-3,6-dioxaoctyl 2-acetamido-3-0-(2,3,4-tri-0- benzyl-α-L-fucopyranosyl)-4,6-0-benzylidene-2-deoxy-j8-D- glucopyranoside (9) A solution of (8) (633 mg, 0.65 mmol) and hydrazine hydrate (1.6 ml, 33 mmol) in aqueous 90% ethanol (45 ml) was boiled under reflux for 24 h, cooled, and concentrated. The residue was acetylated with acetic anhydride-pyridine (50 ml, 1:1) overnight. The solution was concentrated. Column chromatography (chloroform-acetone, 9:1) and re-chromatography (ethyl acetate- heptane, 3:1) of the residue gave amorphous (9) (440 mg, 77%), [o] D -72.6° (c 1.0, CHC1 3 ) . -R NMR data (CDC1 3 , δ) : 7.50 to 7.25 (20H, benzyl), 7.92 (d, IH, J 5.9 HZ, NH), 5.51 (s, IH, CHPh), 5.16 (d, IH, J 3.5 Hz, H-l'), 4.93 (d, IH, J 7.7, H-l), 4.95 to 4,56 (6H, CH 2 Ph) , 4.34 (dd, IH, J 4.9 and 10,4 Hz, H-6) , 4.26 (bt, IH, H-3), 4.12 (bdd, IH, H-5'), 4.06 (dd, IH, J 3.5 and 10.1 Hz, H-2'), 3.95 (dd, IH, J 2.7 and 10.1 Hz, H-3'), 3.90 (bt, IH, H-6) , 3.81 to 3.45 (14H, inter alia OCH 2 ) , 3.40 (m, 2H, CH 2 N 3 ) , 1.74 (s, 3H, NHAc), 0.84 (d, 3H, J 6.4 Hz, CH 3 ) . 13 C NMR data (CDC1 3 , δ) : 170.4 (CO), 138.7 to 126.1 (benzyl), 101.5 (CHPh), 101.2 (C-l), 97.8 (C-l'), 80.6 (C-4), 79.6 SUBSTITUTESHEET (C-3'), 77.7 (C-4'), 76.7 (C-2' or C-5'), 74.9 (C-3), 74.6 (CH 2 Ph), 73.7 (CH 2 Ph) , 72.2 (CH 2 Ph) , 70.6 (CH 2 0) , 70.6 (CH 2 0) , 70.4 (CH20) , 69.9 (CH 2 0) , 68.8 (CH 2 0) , 68.8 (H-6) , 66.7 (C-2' or C-5'), 66.2 (C-5), 57.8 (C-2), 50.6 (CH 2 N 3 ) , 23.2 (NHAc) , 16.2 (CH 3 ). (iii) 8-Amino-3,6-dioxaoctyl 2-acetamido-2-deoxy-3-0-α-L- fucopyranosyl-0-D-glucopyranoside acetic acid salt (10) A solution of (9) (57 mg, 0.065 mmol) in acetic acid-water (9:1, 30 ml) was hydrogenolysed at 200 kPa over 10% Pd/C (100 mg) over night. The mixture was filtered through a layer of Celite and concentrated. The residue was first subjected to column chromatography on silica gel (chloroform-methanol-water, 4:4:1) and then on Al 2 0 3 (Merck, basic, 0.063-0.200 mm, chloroform-methanol-water, 4:4:1) to give amorphous (10) (18 mg, 51%), [α] D -70.6° (c 0.2, water). 1 H NMR data (D 2 0, acetone ref., δ) : 4.98 (d, IH, J 4.0 Hz, H-l'). 4.53 (d, IH, J 8.6 Hz, H-l). 4.32 (bdd, IH, H-5'), 4.05 to 3.42 (19H), 3.19 (m, 2H, CH 2 NH 2 ) , 2.01 (S, 3H, NHAc) , 1.88 (CH 3 COOH) , 1.14 (d, 3H, J 6.6 HZ, CH 3 ) . 13 C NMR data (D 2 0, acetone ref., δ) : 184.2 (CH 3 COOH) , 103.8 (C-l), 102.8 (C-l'), 83.3, 78.8, 74.8, 72.6, 72.5 72.4, 72.0, 71.5, 70.9, 69.8, 69.4, 63.7, 58.1 (C-2), 42.0 (CH 2 NH 2 ) , 26.3 (CH 3 C00H) , 25.2 (NHAc), 18.1 (CH 3 ) . (iv) Fucαl-3GlcNAc/3l-0-Spacer 1-BSA-conjugate (11) Thiophosgene (67 μl, 0.856 mmol) in acetone (6 ml) was added dropwise to an ice-cold solution of (10) (120 mg, 0.214 mmol) in water-ethanol-0.1 M phosphate buffer pH 7 (1:1:1, 30 ml). The pH was kept at 6-7 with aqueous sodium hydroxide (1 M) during the reaction. After 20 min the mixture was extracted with diethyl ether (30 ml), concentrated to a volume of 10 ml, and added to a solution of bovine serum albumin (695 mg, 10.7 mmol) in aqueous sodium hydrogen carbonate (15 ml, 0.1 M, pH SUBSTITUTESHEET 9.3). During the addition, pH was adjusted to 9 with aqueous sodium hydroxide (1 M) . After 24 h the reaction mixture was desalted by ultrafiltration (Filtron, omegacell 150, 10 K) and freeze-dried to give (11) (672 mg) . The degree of substitution was determined by sugar analysis (see M. A. Jermyn, Anal. Chem . 68 (1975), 332-335) to 15-18 mol disaccharide/mol protein. EXAMPLE 4 2-Trimethylsilylethyl 2-acetamido-2-deoxy-4-0-α-L-fuco- pyranosyl- J-D-glucopyranoside (16) (i) Trimethylsilylethyl 3 , 6-di-0-benzoyl-2-deoxy-2-phthalimido- 0-D-glucopyranoside (13) 2-Trimethylsilylethyl-2-deoxy-2-phthalimido-/3-D-glucopyranoside (12) (1.64 g, 4.0 mmol) (prepared as described by K. Jansson, S. Ahlfors, T. Frejd, J. Kilhberg, G. Magnusson, J. Dahmen, G. Noori, and K. Stenvall, J. Org. Chem . 53 (1988), 5629-5647), was dissolved in pyridine-dichloromethane (3:1, 24 ml) and cooled to -45°C. A mixture of benzoyl chloride (1060 ml, 9.1 mmol) and pyridine (900 ml) was added during 30 minutes. The reaction was completed after 3 hours and methanol (40 ml) was added. The solvents were evaporated and the residue was co-evaporated with toluene 3 times. The residue was chromatographed (Si0 2 , heptane/ethyl acetate 2:1→1:1) to give pure (13) (2.38 g, 96%). [α] D 20 +69.4° (c 1.2, CHC1 3 ) . -R NMR data (CDC1 3 δ) ι d 7.3-8.2 (m, 14H, 2 O-benzyl, N-phthalamoyl), 5.88 (dd IH, J 7.1, 8.3 Hz, H-3) , 5.46 (d, IH, J 8.5 Hz, H-l), 4.79 (dABq, IH, J 4.2, 12.4 Hz, H-6) , 4.67 (dABq, IH, J 1.9, 11.7 Hz, H-6) , 4.45 (dd, IH, J 8.4, 10.8 Hz, H-2), 3.8-4.1 (m, 3H, H-4, H-5, OCH 2 CH 2 ) , 3.57 (dt, IH, J 7.2, 9.7 Hz, OCH 2 CH 2 ), 0.7-1.0 (m, 2H, CH 2 Si) , -0.15 (s, 6H, SiMe 3 ) . (ii) 2 -Trimethylsilylethyl 3 , 6-di-0-benzoyl-4-O- (2 , 3 , 4-tri-0- benzy 1-α-L-f ucopyranosyl) -2-deojcy-2-phthalimido-0-D- glucopyranoside (15) SUBSTITUTE SHEET Compound (13) was dissolved in dichloromethane-N,N- dimethylformamide (8 ml, 5:3) and tetrabutylammonium bromide (664 mg, 2.06 mmol) and molecular sieves (4 A, 4 g, activated) was added. To a solution of thioethyl 2,3,4-tri-O-benzyl-l- thio-3-L-fucopyranoside (14) (986 mg, 2.06 mmol) (prepared according to H. Lδnn, Carbohydr. Res . 139 (1985), 105-113) in dichloromethane (8 ml) was added bromine (122 ml, 2.37 mmol) in dichloromethane (2 ml). After 15 min stirring, cyclohexene * (distilled) was added dropwise until the bromine colour disappeared. This solution was then added to the mixture above containing compound (13) and stirred for 48 h. The mixture was then filtered through Celite, the solvents were evaporated and the residue was co-concentrated with toluene three times. Column chromatography of the residue (heptane/ethyl acetate, 5:1→ 1:1) gave (15) (896 mg, 85%), [a]D 20 + 14.6° (c 1.2, CHC1 3 ) . ~R NMR data (CDC1 3 , δ) : 5.44 (d, IH, J 8.5 Hz, H-l), 4.80 (d, IH, J 3.6 Hz, H-l') . (iii) 2-Trimethylsilylethyl 2-acetamido-2-deojcy-4-0-(α-L-fuco- pyranosyl)-0-D-glucopyranoside (16) Compound (15) (760 mg, 0.74 mmol) was dissolved in methanol (7 ml) and sodium methoxide (220 ml, 2 M in methanol) was added. The solution was stirred over night at room temperature and then neutralized with Amberlite IR-120(H). Filtration and evaporation of the solvents gave a syrup. The syrup was dissolved in acetic acid (15 ml) and 10% Pd/C (860 mg) was added. After 1.5 h hydrogenolysis (100 kPa) , the mixture was filtered and the solvents evaporated. The resulting syrup was dissolved in ethanol (18 ml) and hydrazine hydrate was added. The solution was refluxed for 3 h. Evaporation of the solvents and co-evaporation with ethanol 5 times gave a syrup that was dissolved in methanol-water mixture (5:1, 60 ml). Acetic anhydride (5 ml) was added and the solution was stirred for 1.5 h. The solvents were evaporated. Column chromatography (Si0 2 , SUBSTITUTESHEET dichloromethane/methanol, 5:1) gave (16) (100 mg, 29%), [α] D 20 -113.5° (c 0.7, H 2 0) . -R NMR data (D 2 0, δ) i d 4.93 (d, IH, J 3.66 Hz, H-l'), 4.52 (d, IH, J 8.06 HZ, H-l) . EXAMPLE 5 Methyl 2-acetamido-2-deoay-6-0-α-L- fucopyranosyl-0-D-glucopyranoside (22) (i) Ethyl 2-deoxy-2-phthalimido-l-thio-0-D-glucopyranoside (18) Ethyl 3,4,6-tri-0-acetyl-2-deoxy-2-phthalimido-l-thio-/8-D- glucopyranoside (17) (5.79 g, 12 mmol) (prepared according to H. Lδnn, Carbohydr. Res . (1985) 139, 105-113) was dissolved in methanol (250 ml) and methanolic sodium methoxide (0.2 M, 2.5 ml) was added. The mixture was stirred for 15 h. Neutralization with acidic cation exchange resin (Bio-Rad AG ® 50 -X8) , filtration, evaporation and crystallization from water gave (18) (3.83 g, 89%), m.p. approx. 96°C; m.p. after recrystallization 159-161°C; [α] D 22 +9.8° (c 0.9, methanol). -R NMR data (CD 3 OD, CHD 2 OD ref., δ) d: 7.91-7.79 (5H) , 5.32 (d, IH, J 10.5 Hz, H-l), 4.28 (dd, IH, J 10 and 8 Hz, H-3) , 4.05 (t, IH, J 10.5 Hz, H-2), 3.93 (dd, IH, J 12 and 2 Hz, H-6) , 3.73 (dd, IH, J 12 artd 5.5 Hz, H-6) , 3.46 (ddd, IH, J 10, 5.5 and 2 Hz, H-5), 3.40 (dd, IH, J 10 and 8 Hz, H-4) , 2.74 (dq, IH, J 12.5 and 7.5 HZ, SCH), 2.63 (dq, IH, J 12.5 and 7.5 Hz, SCH) and 1.17 (t, 3H, J 7.5 Hz, CH 3 CH 2 ) . (ii) Ethyl 3,4-di-0-acetyl-6-0- (2,3,4-tri-O-benzyl-o-L-fucopyranosyl)- 2-deoxy-2-phthalimido-l-thio-0-D-glucopyranoside (19) Bromine (0.485 ml, 9.4 mmol) was added to a solution of ethyl 2,3,4-tri-0-benzyl-l-thio-/S-L-fucopyranoside (14) (4.5 g, 9.4 mmol) in dichloromethane (70 ml) at 0°C. The mixture was SUBSTITUTESHEET stirred for 35 min and was then evaporated twice with benzene. Cyclohexene (0.5 ml) was added and the mixture was again evaporated with benzene. The residue was dissolved in dichloromethane (25 ml) and then added during 1 h, to a stirred mixture of compound (18) (3.32 g, 9.4 mmol), powdered molecular sieves (20 g, 4 A) and tetraethylammonium bromide (3.5 g) in dimethylformamide (75 ml) . The reaction mixture was stirred for 2 h at 0°C, then for 2 h at room temperature followed by filtering through Celite. The filtrate was partitioned between dichloromethane and saturated aqueous sodium hydrogen carbonate. The aqueous phase was extracted with dichloromethane and the combined organic phases were washed with water, and concentrated. The residue was chromatographed (ethyl acetate- heptane; 1:1→3:1) to give a crude product, which was O-acetylated by stirring in acetic anhydride (50 ml) and pyridine (75 ml) for 17 h at room temperature. Evaporation with toluene and chromatography (ethyl acetate-heptane; 1:2→1:3) gave (19) (3.3 g, 40%), [α] D 22 -4.6° (c 1.4, chloroform). ^-NMR data (CHC1 3 , δ) : 7.90-7.83 (2H) , 7.79-7.71 (2H) , 7.45-7.24 (15H), 5.83 (dd, IH, J 10 and 9.5 Hz, H-3) , 5.43 (d, IH, J 10.5 Hz, H-l), 5.09 (dd, IH, J 10 and 9.5 Hz, H-4) , 4.99 and 4.67 (2H, AB-system, J 11.5 Hz, benzylic H) , 4.97 (d, IH, J 3.5 Hz, H-l'), 4.89 and 4.77 (2H, AB-system, J 12 Hz, benzylic H) , 4.79 and 4.73 (2H, AB-system, J 12 Hz, benzylic H) , 4.39 (t, IH, J 10.5 HZ), 4.06 (dd, IH, J 10 and 3.5 Hz), 3.97-3.87 (3H) , 3.76 (dd, IH, J 12 and 6 Hz), 3.70- 3.62 (2H) , 2.67 (dq, IH, J 12 and 7.5 Hz, SCH), 2.56 (dq, IH, J 12 and 7.5 Hz, SCH), 1.98 (s, 3H, CH 3 CO) , 1.87 (s, 3H, CH 3 CO) , 1.15 (t, 3H, J 7.5 HZ, CH 3 CH 2 ) , 1.13 (d, 3H, J 7.5 Hz, Fuc-CH 3 ) . Calc. for C 47 H 51 N0 12 S : C 66. 1 ; H 6.02 ; N 1. 64 ; S 3 .75. Found: c 66.4 ; H 6.1 ; N 1.55 ; S 3 .25. (ϋi) Methyl 3,4-di-0-acetyl-6-0-(2,3,4-tri- -O-benzyl-α-L-fucopyranosyl)-2-deoxy-2-phtha1imido-0-D-glucopyr anoside (20) SUBSTITUTESHEET To a mixture of (19) (853 mg, 1 mmol), methanol (0.102 ml, 2.5 mmol), N-iodosuccinimide (344 mg, 1.52 mg) and ground molecular sieves (0.9 g, 4 A) in dichloromethane-diethyl ether (2:1, 25 ml) at -30°C, was added trifluoromethanesulphonic acid (0.030 ml, 0.3 mmol). After 2.5 h. the reaction mixture was filtered through Celite into an aqueous solution of sodium hydrogen carbonate and aqueous sodium bisulphite. The organic phase was separated and washed with saturated aqueous sodium chloride, and concentrated. Chromatography (ethyl acetate- heptane; 2:3) of the residue gave (20) (778 mg, 94%), [α] D 22 -2.8° (c 1.1, chloroform) . NMR data (CHC1 3 , δ) : 7.90-7.82 (2H) , 7.78-7.70 (2H) , 7.45-7.24 (15H), 5.79 (dd, IH, J 11 and 9 Hz, H-3), 5.26 (d, IH, J 8.5 Hz, H-l), 5.08 (dd, IE J 10 and 9 Hz, H-4) , 4.99 and 4.67 (AB-system, 2H, J 11.5 Hz, benzylic H) , 4.96 (d, IH, J 3.5 Hz, H-l'), 4.88 and 4.77 (AB-system, 2H, J 12 Hz, benzylic H) , 4.81 and 4.69 (AB system, 2H, J=12 Hz, benzylic H) , 4.28 (dd, IH, J 11 and 8.5 Hz, H-2) , 4.07 (dd, IH, J 10 and 3.5 Hz), 3.99-3.85 (3H) , 3.77 (dd, IH, J 12 and 6 Hz), 3.71-3.64 (2H) , 3.34 (s, 3H, CH 3 0) , 2.00 (S, 3H, CH 3 CO) , 1.86 (s, 3H, CH 3 CO) , 1.14 (d, 3H, J 6.5 HZ, Fuc-CH 3 ) . Calc. for C 46 H 49 N0 13 : C 67.06; H 5.99; N 1.70. Found: C 67.0; H 6.1; N 1.65. (iv) Methyl 2-acetamido-6-0-(2,3,4-tri-0-benzyl-α-L- -fucopyranosyl)-2-deoxy-0-D-glucopyranoside (21) Compound( 20) was deacetylated in methanolic sodium methoxide (9.5 mM, 31.5 ml) for 1.5 h. Neutralization with acidic cation exchange resin (Bio-Rad AG® 50W-X8) , filtration and concentration gave a residue which was dissolved in methanol (20 ml). Hydrazine monohydrate (0.8 ml) was added and the mixture was heated under reflux for 4 h and then cooled to 10°C. Water (15 ml) and acetic anhydride (5 ml) were added and the reaction mixture was stirred at room temperature. After 20 min a white precipitate was obtained. Addition of methanol (10 SUBSTITUTESHEET ml) facilitated stirring. After additional 2.5 h, pyridine (2 ml) was added which resulted in a clear solution. The mixture was then stirred for 30 min. The methanol was evaporated and the aqueous residue was extracted with dichloromethane. The organic phase was washed with 1 M HCl and saturated aqueous sodium hydrogen carbonate, and concentrated. Chromatography (ethyl acetate-methanol, 10:1) of the residue gave (21) (435 mg, 77%) . An analytical sample was crystallized from ethanol, m.p. 224-226°C (d), [α] D 22 -75.4° (c 0.9, CHCl 3 ) . -R NMR data (CDCl 3 -CD 3 OD, 3:1, CHD 2 0D ref., δ) d: 7.41-7.20 (15H), 4.91 and 4.61 (AB-system, 2H, J 11.5 Hz, benzylic H) , 4.80 and 4.70 (AB-system, 2H, J 11.5 Hz, benzylic H) , 4.78 (d, IH, J 3 Hz, H-l'), 4.75 (s, 2H, benzylic H) , 4.24 (d, IH, J 8.5 Hz, H-l), 4.09-3.97 (2H) , 3.92 (dd, IH, J 10 and 2.5 Hz) , 3.86 (dd, IH, J 11 and 2 Hz), 3.77-3.56 (3H) , 3.42 (dd, IH, J 9.5 and 8.5 Hz) 3.36 (S, 3H, CH 3 0) , 1.97 (s, 3H, CH 3 CO) , 1.07 (d, 3H, J 6.5 HZ, Fuc-CH 3 ) . (v) Methyl 2-acetamido-2-deoxy-6-0-o-L-fucopyranosyl-/S-D- glucopyranoside (22) A solution of (21) (362 mg, 0.56 mmol) in acetic acid (50 ml) was hydrogenolysed at 230 kPa over 10% Pd/C (160 mg) over night. The mixture was filtered through a layer of Celite and concentrated. Column chromatography (chloroform-methanol-water, 65:40:10) of the residue gave amorphous (22) (192 mg, 90%,), [β] D 2 -106° (c 1.1, H 2 0). -R NMR data (D 2 0, CH 3 OH ref., δ) : 4.95 ( d, IH, J 4 Hz, H-l'), 4.46 (d, IH, J 8.5 Hz, H-l), 4.15 (q, IH, J 6.5 Hz), 4.02 (dd, IH, J 12 and 1.5 Hz), 3.92 (dd, IH, J 10.5 and 3.5 Hz), 3.84-3.67 (4H), 3.62-3.49 (6H) , 3.51 (s, CH 3 0) , 1.24 (d, 3H, J 6.5 Hz, FUC-CH 3 ) . 13 C NMR data (D 2 0, CH 3 OH ref., δ) : 177.7, 105.0, 102.4, 78.0, 76.9, 74.8, 72.9, 72.5, 71.2, 70.3, 69.7, 60.0, 58.5, 25.2, 18.3. SUBSTITUTESHEET EXAMPLE 6 3,3-Dimethylbutyl 2-acetamido-2-deoxy-6-0-α-L-fucopyranosyl-/J- D-glucopyranoside (24) (i) 3,3-Dimethylbutyl 3,4-di-0-acetyl-6-0-(2,3,4-tri-0-benzyl- o-L-fucopyranosyl)-2-deoxy-2-phthalimido-S-D-glucopyranoside (23) To a stirred mixture of (19) (853 mg, 1 mmol), 3,3 dimethylbutan-1-ol (0.182 ml, 1.5 mmol), N-iodosuccinimide (344 mg, 1.52 mmol) and powdered molecular sieves (0.9 g, 4 A) in dichloromethane-diethyl ether (2:1; 25 ml) at -30°C, was added trifluoromethanesulphonic acid (0.017 ml, 0.19 mmol). After 1 h additional 3,3-dimethylbutan-l-ol (0.100 ml, 0.82 mmol) and trifluoromethanesulphonic acid (0.015 ml, 0.17 mmol) were added and stirring was continued for 2.5 h. The reaction mixture was then filtered through Celite into an aqueous solution of sodium hydrogen carbonate and sodium bisulphite. The organic phase was washed with aqueous sodium chloride and concentrated. The residue was submitted to chromatography (ethyl acetate-heptane; 2:5) to give (23) (740 mg, 83%), [α] D 22 -8.5° (c 1.3, CHC1 3 ) . α H NMR data (CHC1 3 , δ) : 7.89-7.82 (2H) , 7.78-7.70 (2H) , 7.44-7.24 (15 H) , 5.79 (dd, IH, J 11 and 9 Hz, H-3) , 5.32 (d, IH, J 8.5 Hz, H-l), 5.08 (dd, IH, J 10 and 9 Hz, H-4) , 4.99 and 4.66 (AB-system, 2H, J 11.5 Hz, benzylic H) , 4.91 (d, IH, J 3.5 Hz, H-l'), 4.88 and 4.77 (AB-system, 2H, J 12 Hz, benzylic H) , 4.80 and 4.69 (AB system, 2H, J=12 Hz, benzylic H) , 4.29 (dd, IH, J 11 and 8.5 Hz, H-2) , 4.05 (dd, IH, J 10 and 3.5 Hz), 3.99-3.73 (6H), 3.70-3.63 (2H) , 3.38 (m, IH) , 1.98, (s, 3H, CH 3 CO) , 1.87 (S, 3H, CH 3 CO) , 1.30 (m, 2H, OCH 2 CH 2 ) , 1.13 (d, 3H, J 6.5 HZ, FUC-CH3), 0.69 (s, 9H) . Calc for C 51 H 49 N0 13 : C 69.3; H 5.59; N 1.59. Found: C 68.4; H 6.65; N 1.75. SUBSTITUTESHEET ( ii) 3 , 3-Dimethylbύtyl 2-acetamido-2-deoxy-6-0-α-L-fucopyranosyl- 3-D-glucopyranoside (24) Compound (23) (680 mg, 76 mmol) was dissolved in methanol (25 ml). Methanolic sodium methoxide (0.2 M, 1 ml) was added and the mixture was stirred for 3.5 h. Neutralization with acidic cation exchange resin (Bio-Rad AG® 50W-X8) , filtration and evaporation gave a residue which was dissolved in methanol (20 ml). Hydrazine monohydrate (0.5 ml, 10.3 mmol) was added and the mixture was heated under reflux for 3.5 h and then cooled to 10°C. Water (10 ml), methanol (2 ml) and acetic acid anhydride (2.5 ml) were added and the mixture was stirred at room temperature for 2.5 h during which time additional portions of acetic acid anhydride (2.0 and 0.5 ml) were added. The methanol was then evaporated, and the aqueous residue was partitioned between dichloromethane and water. The aqueous phase was extracted with dichloromethane and the organic phase was concentrated. Chromatography of the residue (ethyl acetate-methanol; 20:1) gave a product which was dissolved in acetic acid (50 ml). 10% Pd/C (160 mg) was added and the mixture was hydrogenolyzed at 230 kPa for 4 h at room temperature. The mixture was filtered through a layer of Celite and concentrated. Column chromatography of the residue (chloroform-methanol-water, 150:40:3→65:40:10) of the residue gave amorphous (24) (275 mg, 80%,), [o] D 22 -87.2° (c 0.95, H 2 0). -R NMR data (D 2 0, CH 3 0H ref., δ) : 4.94 (d, IH, J 4 Hz, H-l'), 4.54 (d, IH, J 8.5 Hz, H-l), 4.15 (q, IH, J 6.5 Hz) , 4.03-3.88 (8H) , 2.03 (s, 3H, CH 3 C0N), 1.58-1.40 (2H, OCH 2 CH 2 ) , 1.24 (d, 3H, J 6.5 HZ, FUC-CH 3 ), 0.90 (s, 9H) . 13 C NMR data (D 2 0, CH 3 OH ref., δ) : 177.5, 104.0, 102.4, 77.9, 76.9, 74.9, 73.0, 72.6, 71.2, 71.0, 69.7, 58.6, 45.0, 31.9, 25.2, 18.4. SUBSTITUTESHEET Calc . for C 20 H 37 NO 10 : C 53 . 2 ; H 8.26 ; N 3 . 10. Found: C 51.2 ; H 8.25 ; N 3 .2. EXAMPLE 7 Fucαl-2Gal/Sl-0-spacer 4 -HSA (31) i) Ethyl 2-0-acetyl-3,4,6-tri-0-benzyl-l-thio-j8-D- galactopyranoside (25) Compound (25) was prepared from acetobromogalactose (70.73 g, 0.172 mmol), according to proceedure described by S Nilsson, H Lδnn and T Norberg, Glycoconjugate J., 1989, 6, 21-34. Yield of (25) was 26.13 g (28%) . TLC: Rf 0.33 (heptane:ethyl acetate, 9:2) 13 C-NMR (CDC1 3 ) δ: 170.2 (CO), 139.2, l * r.6, 138.4 (aromatic C), 84.2, 82.1 78.1, 75.0, 74.1, 73.6, 72.6, 70.3, 69.2, (C- 1,2,3,4,5,6, 3x CH 2 Ph) , 24.1 (SCH 2 CH 3) , 21.6 (OCOCH 3 ) , 15.4 (SCH 2 CH 3) . -NMR (CDC1 3 ) δ: 5.43 (bt, IH, J 2/3 9.7 Hz, H-2) , (d IH, J lf2 11.9 Hz, H-l), 4.01 (bd, IH, J 3f4 2.9 Hz, H-4) , 3.55 (dd, IH, H-3) . (ii) Ethyl 2-O-benzoyl-3,4,6-tri-O-benzyl-l-thio-0-D- galactopyranoside (26) Ethyl 2-0-acetyl-3,4,6-tri-0-benzyl-l-thio-3-D- galactopyranoside (25) was deacetylated with sodium methoxide in methanol (50 ml, pH 12) and subsequently benzoylated with benzoylchloride (1.96 gr., 14 mmol) in pyridine (20 ml) according to standard procedures. Crystalline 26 was obtained in almost quantitative yield (3.44 gr. , 97%). NMR (CDC1 3 ) -R: δ 5.70 (IH, t, 9.8Hz, H-2) 2.60-2.80 (2H, m, - CH 2 CH 3 ) , SUBSTITUTESHEET 13 C: δ 14.8, 23.6 (SEt), 68.6, 70.2, 71.7, 72.8, 73.6, 74.4, 76.6, 127.5-138.6 (aromatic C) , 165.4 (C=0) (iii) 2-Azidoethyl 3,4,6-tri-0-benzyl-/S-D-galactoρyranoside (28) To a stirred suspension of the thioglycoside (26) (700 mg, 1.17 mmol), 2-azidoethanol (204 mg, 2.34 mmol; prepared according to A. Ya. Chernyak et al. and A.V. Rama Rao, Carbohydr. Res., 1992, 223, 303-309), N-iodosuccinimide (395 mg, 1.75 mmol,) and ground molecular sieves (3A, 400 mg) in dichloromethane (25 ml) was added at 0°C trifluoromethanesulfonic acid (TfOH; 35 mg, 0.23 mmol; according to method published by G.H. Veeneman, S.H. Van Leeuwen, J.H. Van Boom, Tetrahedron Lett., 1990, 31, 1331). When TLC (toluene:ethyl acetate, 6:1) showed complete conversion ( < 15 minutes) , reaction was quenched by addition of triethylamine at 0°C. The solution was filtered through a layer of celite, diluted with dichloromethane and washed twice with aqueous Na 2 S 2 0 3 (10%) and finally with water. The organic phase was dried over magnesium sulfate, filtered and concentrated and the residue was immediately subjected to TLC (toluene:ethyl acetate, 15:1). Solvent removal left 672 mg of 2-Azidoethyl 2-0-benzoyl-3,4,6-tri-0-benzyl-S-D- galactopyranoside (27) as a colourless oil (92%) , which was treated with sodium methoxide in methanol (pH 11) at room temperature for 6 hours. The solution was neutralized with Dowex 50 H + resin, filtered and concentrated. The crystalline product (28) (540 mg, 89% from 2) was used without further purification for the preparation of disaccaride (29) . Compound (27): NMR (CDC1 3 ) ~R: 55.66 (IH, dd, 10.0, 7.9 HZ, H- 2) 4.57 (IH, d, 7.8 Hz, H-l) 13 C: δ 50.7 (CH 2 N 3 , 67.3, 68.7, 71.9, 72.5, 73.6, 73.9, 74.5, 101.4 (C-l), 127.6-137.8 (aromatic C) , 165.3 (C=0) Compound (28): 13 C: δ 50.7 (CH 2 N 3 ) , 68.4, 68.7, 71.4, 72.6, 73.0, 73.6, 73.9, 74.5, 81.7, 103.4 (C-l), 125.3-138.4 (aromatic C) SUBSTITUTESHEET (iv) 2-Azidoethyl 3,-4,6-tri-0-benzyl-2-0-(2 ,3 ,4-tri-O-benzyl-α- L-fucopyranosyl)-3-D-galactopyranoside (29) To a solution of thioethylglycoside (14) (400 mg, 0.836 mmol) in dichloromethane (10 ml), bromine (134 mg, 0.836 mmol) was added at 0°C. After about 5 minutes at 0°C, the solution was allowed to attain room temperature and the solvent was evaporated. After co-evaporation with toluene the residue was dissolved in dichloromethane (2 ml) and added at room temperature to a suspension of tetraethylammonium bromide (176 mg, 0.836 mmol; prepared according to R.U. Lemieux, K.B. Hendriks, R.V. Stick, K. James, J. Am. Chem. Soc. 1975, 97:14, 4056) , compound (28) (290 mg, 0.558 mmol) and ground molecular sieves (3A, 300 mg) in CH 2 C1 2 :DMF (4:1, 7 ml). TLC (toluene:ethyl acetate, 6:1) showed complete conversion after stirring for 20 hours. The mixture was filtered, diluted with dichloromethane and washed with water. The organic phase was dried over magnesium sulfate and filtered and concentrated in vacuo. Preparative TLC yielded the title compound (29) as a viscous oil (407 mg, 78%) . NMR (CDC1 3 ) 13 C: δ 16.5, 33.6, 50.9, 66.4, 66.9, 68.8, 71.4, 72.0, 72.8, 72.9, 73.5, 73.6, 74.4, 74.8, 75.7, 78.1, 79.6, 84.3, 97.3, 102.0, 125.3-129.0 (aromatic C) , 138.0, 138.3, 139.0. (v) 2-Aminoethyl 2-0-o-L-fucopyranosyl-/3-D-galactopyranoside (30) The protected disaccaride derivative (29) (80 mg, 85 μmol) was dissolved in ethanol (abs., 10 ml) and water (1 ml) and Pd/C (10%, 100 mg) was added. The mixture was hydrogenated and stirred rapidly at room temperature at 50 PSI. When reaction was not completed within 60 hours, the mixture was filtered and the product formed was isolated (TLC, ethyl acetate:methanol:acetic acid:water, 5:3:3:1, R f =0.15). After concentration in vacuo, the residue was resolved in a buffer of aqueous pyridine/acetic acid (2.5%/l%, pH 5.4) and eluated SUBSTITUTESHEET through a Bio Gel P-2 column. Evaporation and freeze drying gave 14 mg (44%) of the title compound (30) as a white powder. NMR (CDC1 3 ) 13 C: δ 16.8, 39.8, 61.1, 66.4, 67.1, 68.7, 69.6, 71.9, 73.0, 75.0, 78.4, 100.0, 101.7 (vi) Fucαl-2Galj8l-0-spacer 4-HSA (31) To a stirred ice-cooled solution of thiophosgene (10 eq.) in tetrahydrofuran (2 ml), the amino derivative (30) (30 μmol) in sodium borate buffer (0.85 M, 2 ml, pH 8.5) was added. The solution was stirred at room temperature for 10 minutes and then extracted with diethylether (3 x 2 ml) . The aqueous phase containing the isothiocyanate derivative was added to a solution of Human Serum Albumine (HSA) (1/30 eq.) in the same buffer system (0.5 ml). pH was adjusted to 8.5 with aqueous sodium hydroxide (0.25 M) and the mixture was stirred at room temperature for 48 hours. Freeze drying of the reaction mixture was followed by ultracentrifugation purification with Centriprep tubes (10KO) . Freeze drying of the purified solutions gave the HSA-conjugates (31) in excellent yield (18 mg) .The degree of substitution was determined by Time of Flight masspectroscopy to 8 mol disaccharide/mol protein. EXAMPLE 8 Fucαl-2Gal/3l-0-spacer 1-HSA (36) (i) 8-Azido-3,6-dioxaoctyl 3,4,6-tri-0-benzyl-/?-D- galactopyranoside (33) The azidoderivative (33) was synthesized from the thioglycoside (26) (1004 mg, 1.68 mmol) and l-azido-8-hydroxy-3,6-dioxaoctane (686 mg, 3.35 mmol; prepared according to C.R. Bertozzi, M.D. Bednarski, J. Org. Chem., 1991, 56, 4326-4329) according to a procedure similar to the one used for synthesis of derivative (28) (TLC; toluene:EtOAc 6:1) showed complete conversion within 40 minutes. Similar workup and deacylation of 8-azido-3,6- SUBSTITUTESHEET dioxaoctyl 2-0-benzoyl-3,4,6-tri-0-benzyl-3-D-galactopyranoside (32) yielded 933 mg (78% from 26) of the title compound (33) as a viscous oil. Compound (32); NMR (CDC1 3 ) : ~R: δ 5.64 (IH, dd, 10.0, 7.9 Hz, H-2). 13 C: δ 50.6 (CH 2 N 3 ) , 68.7, 68.9, 69.8, 70.3, 70.5, 70.7, 71.8, 71.9, 72.6, 73.6, 73.8, 74.6, 80.0, 101.6 (C-l) Compound (33); 13 C: δ 50.6 (CH 2 N 3 ) , 68.7, 68.8, 70.0, 70.2, 70.5, 70.6, 71.4, 72.6, 73.3, 73.5, 73.8, 74.5, 81.9, 103.8 (C- 1) (ii) 8-Azido-3,6-dioxaoctyl 3,4,6-tri-0-benzyl-2-0-(2,3,4-tri- 0-benzyl-α-L-fucopyranosyl)-0-D-galactopyranoside (34) Disaccaride (34) was synthesized from compound (33) (500 mg, 0.82 mmol) and thioethylglycoside (14) (512 mg, 1.07 mmol) according to the procedure described for the corresponding derivative (29) . Preparative TLC gave 683 mg (81%) of the title compound (34) as an oil. NMR (CDC1 3 ) 13 C: δ 18.3, 50.2, 66.2, 68.2, 68.8, 70.0, 70.2, 70.3, 70.6, 71.2, 72.0, 72.3, 72.5, 73.0, 73.3, 73.6, 74.4, 74,6, 75.8, 78.0, 79.7, 84.2, 98.6, 102.0 (iii) 8-Amino-3,6-dioxaoctyl 2-0-α-L-fucopyranosyl-3-D- galactopyranoside (35) 8-Azido-3,6-dioxaoctyl 3,4,6-tri-0-benzyl-2-0-(2,3,4 tri-o- benzyl-Q.-L-fucopyranosyl)-/S-D-galactopyranoside (34) (35 mg, 34 μmol) was dissolved in a mixture of ethyl acetate:ethanol:water in 1:2:2 (vol., 12 ml) and acidified with 20 μl HOAc (according to method published by S. Nilsson, Doctoral dissertation, Lund University, April 1992) . The solution was hydrogenated at 50 PSI on 10% Pd/C (140 mg) at room temperature overnight and when TLC (ethyl acetate:methanol:acetic acid:water, 5:3:3:1) showed complete deprotection, the mixture SUBSTITUTESHEET was filtered and evaporated. Purification on a Bio-Gel* P-2 column (aq. pyridine:acetic acid, 2.5:1 by vol., pH 5.4) concentration and freeze drying gave the title compound (35) as a white powder (14 mg, 90%) . NMR (CDC1 3 ) 13 C: δ 15.2 (CH 3 ) , 38.9, 60.7, 66.1, 66.5, 68.1, 68.5, 68.7, 69.2, 69.3, 69.4, 69.6, 71.7, 73.4, 74.8, 76.6, 99.2 (C-l j, 101.4 (C-l). (iv) Fucαl-2Gal01-0-spacer 1-HSA (36) To a stirred ice-cooled solution of thiophosgene (10 eq.) in tetrahydrofuran (2 ml) , the amino derivative (35) (30 μmol) in sodium borate buffer (0.85 M, 2 ml, pH 8.5) was added. The solution was stirred at room temperature for 10 minutes and then extracted with diethylether (3 x 2 ml) . The aqueous phase containing the isothiocyanate derivative was added to a solution of Human Serum Albumine (HSA) (1/30 eq.) in the same buffer system (0.5 ml) . pH was adjusted to 8.5 with aqueous sodium hydroxide (0.25 M) and the mixture was stirred at room temperature for 48 hours. Freeze drying of the reaction mixture was followed by ultracentrifugation purification with Centriprep tubes (10KO) . Freeze drying of the purified solutions gave the HSA-conjugates 36 in excellent yields (33 mg) . The degree of substitution was determined by Time of Flight masspectroscopy to 5 mol disaccharide/mol protein. EXAMPLE 9 Fucαl-2Gal/Sl-0-spacer 2-PAA (38) (i) 8-N-acrylamido-3.6-dioxaoctyl 2-0-α-L-fucopyranosyl-j8-D- galactopyranoside (37) 0.8 ml deaerated 0.5 M sodiumborate aq. buffer (pH 8.5) and 2.4 ml deaerated methanol was added to 15 mg of the compound (35) . The reaction mixture was flushed with nitrogen and cooled to SUBSTITUTESHEET 0°C. 3.3 μl of acryioylchloride was added and stirring was continued for 10 minutes. The reaction mixture was concentrated at room temperature to about a third of its original volume. Purification on a Bio-Gel* P2 column and lyophilization gave the title compound (37) (14 mg, 83%) NMR-data: 13 C (D 2 0) : δ 15.0 (CH 3 ) , 38.54 (CH 2 N) , 60.51, 66.31, 67.87, 68.19, 68.30, 68.50, 68.98, 69.10, 69.12, 69.43, 71.50, 73.25, 74.55, 76.08 (C-2,3,4,5,6; C-2,3,4,5; 5xCH 2 0) 98.88 (C- 1'), 101.16 (C-l), 126.92 and 129.43 (CH=CH 2 ) . (ii) Fucαl-2Gal01-0-spacer 2-PAA (38) To a solution of the compound (37) (14 mg, 0.027 mmol) and acrylamide (9.7 mg, 0,14 mmol) in deaerated water (1 ml) was added first N,N,N'N'-tetramethylendiamine (6 μl) and then ammonium persulphate (3.5 mg) . The mixture was stirred at roomtemperature over night. The polymer (38) obtained was purified by gel chromatography on a Bio-Gel* P2 column. Freeze-drying of the purified solutions gave the PAA conjugate in excellent yield (17.9 mg) . H-NMR showed an average incorporation of 1 oligosaccharide per 7 acrylamide units. EXAMPLE 10 FUCttl-2Gal/3l-3(Fucαl-4)GlcNAC/S-3Gal/Sl-4GlC|Sl-NH-PAA (42) (i) Fucαl-2Gal3l-3(Fucαl-4)GlcNAc01-3Gal/3l-4GlcjSl-NH 2 (40). Solid ammonium bicarbonate was added until saturation to a solution of Fucαl-2Gal3l-3(Fucαl-4)GlcNAc3l-3Gal3l-4Glcl-0H (Lewis B hexasackaride (39) , purchased from Iso Sep AB, 25 mg in water (1.25 mL) . The mixture was stirred in an open vessel at room temperature for 6 days. Ammonium bicarbonate was added at intervals, saturation was assured by always keeping a portion of solid salt present in the mixture. When TLC indicated no more conversion, the mixture was diluted with water (5 mL) and concentrated to half the original volume. The residue was diluted to 20 mL with water and concentrated to 5 mL. This process was repeated once, then the residue was SUBSTITUTESHEET diluted to 10 L and lyophilized. The crude product was put on a Bio-gel P2-column, and the fraction containing Lewis B glycosylamine (40) was collected, (20 mg 80%) . NMR data: 13 C (D 2 0) : δ 84.66 (C-NH 2 ), 97.54, 99.33, 100.39, 100.72, 102.98 (C-l carbons of the nonreducing sugarunits) , 15.08, 15.13 (2xCH 3 -fucose) , 21.95 (CH 3 -C0N-GlcNAc) . (ii) Fucαl-2Gal01-3(Fucαl-4)GlcNAc01-3Gal/3l-4Glc/3l-NH-CO-CH=CH 2 (41) Sodium carbonate (50 mg) and deaerated methanol (0.5 mL) was added to a solution of the glycosylamine (40) (20 mg, 0.02 mmol) in water (0.5 mL) . The mixture was stirred at 0°C while acryloyl chloride (60 μL. , 0.74 mmol) in tetrahydrofuran (0.5 mL) was added during 5 min. After 10 min. the solution was diluted with water (3 mL) and concentrated to 2 mL. The solution was again diluted with water (2 mL) , 200 μL tetrahydrofuran (inhibitor solution) was added, and the solution was concentrated to 1-2 mL. This solution was purified by gel filtration on a Bio-Gel* P2 column. Appropriate fractions were pooled and lyophilized to obtain the title compound (41) (14 mg, 67%). NMR data: 13 C (D 2 0) : δ 81.28 (C-NHCOCHCH 2 ) , 97.42, 99.18, 100.25, 102.59, 102.85 (C-l carbons of the nonreducing sugarunits), 14.99, 15.06 (2xCH 3 -fucose) , 21.92 (CH 3 CON- GlcNAc) , 125.93, 130.32, (CH=CH 2 ) . Fab ms: pseudomolecular ion m/z; 1053 (M+H) and 1075 (M+Na) + . (iii) Fucαl-2Gal/3l-3 (Fucαl-4 ) GlcNAc£-3Gal01-4Glc/?l-NH-PAA (42) Copolymerization of N-Acryloylglycosylamine with acrylamide. A solution of the N-acryloylglycosylamine (41) (13 μmol) and acrylamide (53 μmol, 3.7 mg) in distilled water (200 μL) was deaerated by flushing with nitrogen for 20 min. The solution was then stirred at 0°C and N, N, N, ' ,N' - tetramethylethylenediamine (2 μL) and ammonium persulfate ( 1 SUBSTITUTE SHEET mg) were added. The- mixture was slowly stirred at 0°C for 2 hours and then at room temperature overnight. The viscous solution was diluted with water (1 mL) and purified by gel filtration on Bio-Gel* P2 column eluated with aqueous n- buthanol (1%) . Fractions containing polymer were pooled and lyophilized. Yield: 3mg. H-NMR shows presence of approximately 1 Lewis-B unit per 5 CHCH 2 units. EXAMPLE 11 Fucαl-2Gal 3l-3GLcNAc3l-0-Spacer 5 -PAA (50) (i) 2-azidoethyl 4,6-0-benzylidene-2-deoxy-2-phthalimido-3-D- glucopyranoside (43) Ethyl 4,6-0-benzylidene-2-deoxy-2-phthalimido-l-thio-3-D- glucopyranoside (prepared according to H Lδnn, Carbohydr. Res., 139 (1985) f 105-113) (0.5 g, 1.1 mmol) was dissolved in 20 ml of dichlorc athane and 2-azidoethanol (prepared according to Chernyak A.Y. et al. Carbohydr. Res., 1992, 223, (303-309) (0.148 g, 1.7 mmol) crushed 4A molecular sieves were added and the mixture stirred for 30 min. Dimethyl(methylthio)sulfonium triflate (DMTST) (0.439 g, 1.7 mmol; prepared according to P. Fiigedi and P.J. Garegg, Carbohydr. Res., 149 (1989), 9-12) was added at room temperature and stirring was continued for 4 hours. Analysis by TLC (toluene-ethylacetate) show no starting material, and to the reaction mixture was added 1 ml of triethylamine and stirring was continued for another 30 min. The reaction mixture was transfered to a silica gel column and eluted with toluene:ethylacetate 6:1 to give (372 mg, 72%) of the title compound (43). NMR-data: 13 C (CDC1 3 ) : δ 50.38 (CH 2 -N) ; 56.42 (CH-N) ; 66.2, (CH-O) ; 68.44 (CH 2 0) ; 68.50 (CH-O; 68.53 (CH 2 -0) ; 82.05 (CH-O); 98,89 (C-l); 101.83 (PhCH) . SUBSTITUTESHEET (ii) 2-Azidoethyl 3-0-(2-0-acetyl-3,4,6-tri-0-benzyl-0-D- galcatopyranosyl)-4,6-0-benzylidene-2-deoxy-2-phthalimido-/3-D- glucopyranoside (44) Ethyl 2-0-acetyl-3,4,6-tri-0-benzyl-l-thio-3-D- galactopyranoside (25) (818 mg, 1.5 mmol) and the compound (43) (395 mg, 0.85 mmol) were dissolved in 30 ml of dichloromethane, crushed 4A molecular sieves were added and the mixture stirred for 20 min. The reaction was flushed with nitrogen and DMTST (787 mg, 3.05 mmol, dissolved in 5 ml of dichloromethane) was added dropwise to the reaction mixture and the dropfunnel rinsed with 6 ml of dichloromethane. After 2 hours 1 ml of triethylamine was added and stirred for 30 min., filtration, concentration and column chromatography (toluene:ethylacetate 10:1 gave three fractions. Fraction 1 the α-product (97.32, 98.89; (C-l and C-l'). Fraction 2 almost pure 44 (306 mg, 39%). NMR-data: 13 C (CDC1 3 ref. tetramethylsilane O ppm) : δ 20.32 (CH 3 CO) , 50.47 (CH 2 N) , 55.13 (CH-N) , 66.57, 68.15, 68.20, 68.65, 71.58, 71.71, 72.17, 72.94, 73.46, 74.38, 75.15, 80.47, 81.08 (C-3,4,5,6 C-2,3,4,5,6; 3xCH 2 Ph; CH 2 -0) , 98.86 (C-l), 100.75, 101.23 (C-l and CH Ph) , 168.84 (C=0) . (iii) 2-azidoethyl 2-acetamido-3-O-(3,4,6-tri-0-benzyl-?-D- galactopyranosyl)-4,6-0-benzylidene-2-deoxy-S-D-glucopyranoside (45) To compound (44) (525 mg, 0.56 mmol) was added 50 ml of ethanol and 1.1 ml of hydrazinhydrate reflux over night and TLC (toluene:ethylacetate 1:2) showed a new product. Concentration and coevaporation with toluene, followed and then dissolving in 45 ml of dichloromethane and washing with an equal amount of water, coevaporation with toluene, gave the crude monohydroxy amine. This crude product was dissolved in dichloromethane:methanol (1:1, 15 ml) and 1.5 ml of acetic anhydride was added. After 3 hours no starting material was left (TLC) . Concentration and chromatography (toluene- SUBSTΓΓUTE SHEET ethylacetate 1:2) gave (204 mg, 45%) of the title compound (45). NMR-data: 13 C (CDC1 3 ) : δ 23.59 (NHCOCH 3 ) , 50.59 (C-N) , 56.89 ' 5 (C-N), 66.40, 68.28, 68.56, 70.55, 72.44, 73.21, 73.40, 73.53, 74.60, 76.08, 79.75, 81.71 (C-3,4,5,6; C-2',3',4' ,5' ,6'; 3xCH 2 Ph; CH 2 0) 100.97, 101.25, 103.48 (C-l, C-l 1 and CHPh), 171.67 (C=0). 10 (iv) 2-azidoethyl 2-acetamido-3-0-(3,4,6-tri-0-benzyl-2-0- (2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-0-D-galctopyranosyl]- 4,6-0-benzylidene-2-deoxy-j3-D-glucopyranoside (46) The compound (45) (137 mg, 0.17 mmol) and the compound (14) 15 (162 mg, 0.34 mmol) were dissolved in dichloromethane (75 ml), and molecular sieves (4A) were added, and the mixture was stirred for 20 min. DMTST (96 mg, 0.37 mmol) was added and stirring was continued for 1.5 hours. 1 ml of triethylamine was added and stirring was continued for another 20 min. Filtration 20 through celite, concentration and column chromatography (toluene:ethylacetate 1:1) gave (46) (101 mg, 49%). NMR-data: 13 C (CDC1 3 ) : δ 16.83 (CH 3 fucose) , 23.30 (NHCOCH 3 ) , 50.66 (CH 2 -N) , 57.40 (C-2), 66.55, 67.17, 67.96, 68.60, 72.31, 25 72.91, 72.99, 73.04, 73,10, 73.51, 74.48, 74.65, 76.05, 76.29, 76.62, 77.60, 79.43, 79.53, 83.21 (C-3,4,5,6; C-2',3' ,4',5',6'; C-2 M , 3",4",5"; 6xCH 2 Ph) , 97.67 (C-l") , 100.94, 101.07, 102.13 (C-l, C-l', CHPh), 170.92 (C=0) . 30 (v) 2-trifluoracetamidoethyl 2-acetamido-3-0-[3,4,6-tri-0- benzyl-2-O-(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-0-D- galactopyranosy1]-4,6-0-benzylidene-2-deoxy-S-D-glucopyranoside (47). 35 The compound (46) (135 mg, 0.11 mmol) was dissolved in 11 mL of ethanol and 10% Pd/C (140 mg) was added. The reaction mixture was hydrogenated at atmospheric pressure for 15 minutes. Analysis by Tic (ethyl acetate:methanol:acetic acid:water SUBSTITUTESHEET 12:3:3:1) showed no starting material, but one ninhydrin positive product. The mixture was filtered through celite, concentrated and dissolved in dichloromethane (7 mL) , and pyridine (3.5 mL) , flushed with nitrogen and cooled to 0°C. Trifluoroacetic anhydride (31 μl, 0.22 mmol) was added. After one hour the mixture was concentrated and coevaporated with 2 ml of toluene twice. Column chromatography (toluene:ethyl acetate, 1:3) gave 47 (73 mg, 52%) NMR-data: 13 C (CDC1 3 ) : δ 17.06 (CH 3 fucose) 22.66 (NHCOCH 3 ) , 39.59 (CH 2 -N), 54.83 (C-2), 65.56, 66.77, 67.78, 68.44, 68.69, 72.80, 73.05, 73.24, 2x73.46, 74.46, 74.66, 76.38, 77.08, 77.80, 78.91, 79.96, 80.01, 82.07, (C-3,4,5,6; C- 2',3',4',5',6'; C-2",3",4",5"; 6xCH 2 Ph) 98.61 (C-l"), 101.22, 101.99, 102.35 (C-l, C-l', CHPh), 171.64 (NHCOCH 3 ) . (vi) 2-trifluoroacetamidoethyl 2-acetamido-2-deoxy-3-0-[2-0- (α-L-fucopyranosyl)-0-D-galactopyranosyl]-0-D-glucopyranoside (48) Trisaccharide (47) (73mg, 56.2 μmol) was dissolved in absolute ethanol (7 ml) with water (0.25 ml) and glacial acetic acid (2 μl) . The solution was hydrogenated over 10% Pd/C (152 mg) at 50 PSI at room temperature for 1 hour. When TLC (ethyl acetate:acetic acid:methanol: ater 12:3:3:1; R f = 0.14 for the compound (48) showed complete conversion, the reaction mixture was filtered through a layer of celite and concentrated. The crude, solid residue (46 mg) was used in the next reaction without further purification. NMR-data: 13 C (D 2 0) : δ 16.59 (CH 3 fucose), 21,85 (NHC0CH 3 ) , 39.44 (CH 2 -N) , 54.56 (C-2), 60.45-76.95 (C3,4,5,6, C2',3',4',5',6', 2",3",4",5") 99.29, 99.92, 101.28 (C-l, C-l', C-l"), 173.48 (NHC0CH 3 ) . SUBSTITUTESHEET (vii) 2-acrylamidoethyl 2-acetamido-2-deoxy-3-0-2-0-α-L- fucopyranosyl-0-D-galactopyranosyl-0-D-glucopyranoside (49) The crude compound (48) (46 mg) was dissolved in aqueous ammonia (25%, 4 ml) and stirred at room temperatur. The reaction was complete within 1 hour and yielded the free amino derivative exclusively. (TLC ethyl acetate:acetic acid:methanol :water 5:3:3:1). Concentration and co-concentration with toluene was followed by purification on a Bond-Elut* (SCX, H + - form) cation exchange resin 0.5 g cartridge. The sample was dissolved in 3 ml of water and pH was adjusted to pH 6 with aqueous acetic acid. The sample was put on the column and then eluted with 2M ammonia in methanol:water, 1:1 (5 ml) . The fractions containing free amine (ninhydrin positive) were pooled, concentrated and lyophilized to give (30 mg, 0.05 mmol) crude amine. 1 ml deaerated 0.5 M sodiumborate (aq buffer (pH 8.5) and deaerated methanol (3 ml) was added to the crude amine. The reaction mixture was flushed with nitrogen and cooled to 0°C, 6.4 μl (0.078 mmol) acryloylchloride was added and stirring was continued for 10 minutes. The reaction mixture was concentrated at room temperature to about a third of its original volume. Purification on a Bio-Gel* P2 column and lyophilization gave 49 of the title compound (49) (30 mg, 86% from (47)). NMR-data: 13 C (D 2 0) : δ 14.99 (-CH 3 , fucose), 21.99 (NHC0CH 3 ) , 39.10 (CH 2 N) , 54.58 (C-2) 99.25, 99.93, 101.39 (C-l, C-l, C"- 1), 127.27, 129.65 (CH=CH 2 ) . (viii) Fucαl-2GalSl-3GlcNAcj8l-0-spacer 5-PAA (50) Copolymerization of 2-acrylamidoethyl 2-acetamido-2-deoxy-3-0- 2-0-α-L-fucopyranosyl-3-D-galactopyranosyl-3-D-glucopyranoside (49) with acrylamide. To acrylamide (10 mg, 144 μmol) was added at room temperature a solution of the trisaccharide (49) (18 mg, 29 μmol) in SUBSTITUTESHEET deaerated water (1 ml) . To this slowly stirred solution (kept in the dark and under nitrogen) was added at 0°C, first N,N,N',N'-tetramethylethylenediamine (6 μl) , and then ammonium persulphate (3.5 mg) . The mixture was stirred at room temperature over night. TLC (ethyl acetate:acetic acid:methanol :water 5:3:3:2) showed that almost all of the compound (49) was consumed and that a charring baseline product had been formed. The polymer was purified by gel chromatography on a Bio-Gel* P- 2 column eluted with aqueous n-butanol (1%) . Freeze-drying of the polymeric fraction eluted in the void volume gave 13.1 mg of the polymer (50) were the ~R NMR analysis of the product showed an average incorporation of 1 trisaccharide per 7.6 acrylamide units, and 11.9 mg of polymer (50) were the α H NMR analysis of the product showed an average incorporation of 1 trisaccharide per 10.3 acrylamide units. EXAMPLE 12 Fucαl-2Gal01-3 (Fucαl-4)GlcNAC/Sl-O-spacer 5-PAA (55) (i) 2-azidoethyl 2-acetamido-6-0-benzyl-3-0-(3,4,6-tri-O- benzyl-0-D-galactopyranosyl)-2-deoxy-?-D-glucopyranoside (51) . Diethyl ether saturated with hydrogen chloride was added, at roomtemperature, to a stirred mixture of 2-azidoethyl 2- acetamido-3-0-3,4,6-tri-0-benzyl-/3-D-galactopyranosyl-4,6-0- benzylidene-2-deoxy-/S-D-glucopyranoside (45) (420 mg, 0.52 mmol), sodium cyanoborohydrids (200 mg, 3,2 mmol) and molecular sieves 3A in tetrahydrofuran (20 ml) until the mixture was acidic (as determined with indicator paper; method according to M. Nilsson and T. Norberg Carbohydr. Res., 183 (1988 71-82). The mixture was stirred for 20 min. at roomtemperature and then triethylamine (0.30 mL) was added. The mixture was filtered through Celite, washed with water, dried and evaporated. The crude product was purified by column chromatography (toluene: ethyl acetate, 6:1) to give pure compound (51) (266 mg, 0.32 mmol, 65%). SUBSTITUTESHEET NMR-data: 13 C (CDC1 3 ) : δ 23.41 (NHCOCH 3 ) , 50, 30 (CH 2 N) , 56, 81 (C-N), 66,3-81,9 (C-3,4,5,6; C-2' ,3' ,4',5',6'; 4xCH 2 Ph; CH 2 0) 100.90, 103.21 (C-l, C-l'), 173,4 (CO) (ii) 2-azidoethyl 2-acetamido-2-deoxy-4-0-(2,3,4-tri-0-benzyl- α-L-fucopyranosyl)-3-0-[3 ,4 ,6-tri-0-benzyl-2-0-(2 ,3,4-tri-O- benzyl-α-L-fucopyranosyl)-0-D-galactopyranosyl]-0-D- glucopyranoside (52) . The compound (51) (157 mg, 0.19 mmol) and the compound (14) (362 mg, 0.76 mmol) were dissolved in dichloromethane (100 ml), and 3g 4A molecular sieve (MS) were added and stirred for 20 min. Dimethyl (methylthio)sulfonium triflate (DMTST) (207 mg, 0.80 mmol) was added and stirring was continued for 1.5 hour. 2 ml of triethylamine was added and stirring was continued for another 20 min. Filtration through celite, concentration and column chromatography (toluen:ethylacetate, 1:1) gave the title compound (52) (142 mg, 0.086 mmol, 45%). NMR-data: 13 C (CDC1 3 ) : δ 17.01, 16.81 (2xCH 3 fucose), 23.20 (NHCOCH 3 ) , 50.35 (CH 2 -N) , 57.21 (C-2), 98.31, 99.70, 101.14, 102.30 (Cl, Cl', 2xCl-fucose) , 170.30 (C=0) . (iii) 2-trifluoroacetamidoethyl 2-acetamido-2-deoxy-4-0- (2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-3-0-[3,4,6 tri-O-benzyl- 2-0-(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-0-D- galactopyranosyl]-j3-D-glycopyranoside (53) . The compound (52) (140 mg, 0.084 mmol) was dissolved in 11 ml ethanol and 10% Pd/C (150 mg) was added. The reaction mixture was hydrogenated at atmospheric pressure for 15 minutes. Analysis by TLC (ethyl acetate:methanol:acetic acid:water 12:3:3:1) showed no starting material, but one ninhydrin positive product. The mixtures was filtered through celite, concentrated and dissolved in dichloromethane (10 ml) and pyridine (3.5 ml), flushed with nitrogen and cooled to 0°C. SUBSTITUTESHEET Trifluoroacetic anhydride (31 μl, 0.22 mmol) was added. After one hour the mixture was concentrated and coevaporated with 2 ml of toluene twice. Column chromatography (toluene:ethyl acetate 1:2) gave the compound (53) (82.8 mg, 0.053 mmol, 63%). NMR-data: 13 C (CDC1 3 ) : δ 17.33, 16.93 ( 2xCH 3 fucose), 22.30 (NHCOCH 3 ), 39.25 (CH 2 -N) , 54.48 (C-2), 99.03, 99.98, 101.63, 102.75, (Cl, Cl', 2xCl-fucose) , 171.73 (NHCOCH 3 ) . (iv) 2-trifluoroacetamidoethyl 2-acetamido-2-deoxy-3-0-(2-0-α- L-fucopyranosyl-/3-D-galactopyranosyl)-4-0-α-L-fucopyranosyl-0- D-glucopyranoside (54). The tetrasaccharide (53) (78 mg, 0.05 mmol) was dissolved in absolute ethanol (8 ml) with water (0.25 ml) and glacial acetic acid (2 μL) . The solution was rapidly stirred with 10% Pd/C (150 mg) under hydrogen (50 PSI) at room temperature for 1 hour. When TLC (ethyl acetate:acetic acid:methanol:water 12:3 3:1; showed complete conversion, the reaction mixture was filtered thorugh a layer of celite and concentrated. The crude compound (54) (35 mg) was used in the next reaction without further purification. NMR-data: 13 C (CDC1 3 ) : δ 16.91, 16.53 (2xCH 3 fucose), 22.15 (NHCOCH 3 ) , 39.14 (CH 2 N) , 54.20 (C-2), 99.33, 100.03, 101.73, 102.95 (C-l, C-l', 2xC-l fucose) , 173.30 (NHCOCH 3 ) there were no 13 C signals in the "aromatic region". (v) 2-acrylamidoethyl 2-acetamido-2-deoxy-3-0-(2-0-(α-L- fucopyranosyl-/3-D-galactopyranosyl)-4-0-α-L-fucopyranosyl-|8-D- glucopyranoside (55) . 35 mg of the crude compound (54) was dissolved in aqueous ammonia (25%, 4 ml) and stirred at room temperature. The reaction was complete within 1 hour and yielded the free amino derivative exclusively. TLC (ethylacetate:acetic acid: methanol:water, 5:3:3:2), concentration and co-concentration SUBSTITUTESHEET with toluene was followed by purification on a Bond-Elut* cartridge (SCX, H + -form) cation exchange resin. The sample was dissolved in 3 ml of water and pH was adjusted to 6 with aqueous acetic acid. The sample was put on the column and then eluted with 2M ammonia in methanol:water, 1:1 (5 ml) . The fractions containing free amine (ninhydrin positive) were pooled, concentrated and lyophilized to give crude amine (20 mg) . 1 ml Deaerated 0.5 M sodiumborate (aq) buffer (pH 8.5) and deaerated methanol (3 ml) was added to the crude amine. The reaction mixture was flushed with nitrogen and cooled to 0°C. 6 μL acryloylchloride was added and stirring was continued for 10 min. The reaction mixture was concentrated at room temperature to about a third of its original volume. Purification on a Bio- Gel* P2 column and lyophilization gave pure title compound (55) (15 mg) . NMR-data: 13 C (D 2 0) : δ 16.90, 16.45 (2xCH 3 fucose), 21.95 (NHCOCH 3 ) 39.51 (CH 2 N) , 54.31 (C-2) 99.21, 99.95, 101.56, 102.87 (C-l, C-l', 2xC-l fucose) , 127.21, 129.57 (CH=CH 2 ) 173.27 (NHC0CH 3 ). (vi) Fucαl-2Gal3l-3(Fucαl-4)GlcNAc/Sl-O-spacer 5-PAA (56) Copolymerization of 2-acrylamidoethyl 2-acetamido-2-deoxy-3-0- 2-0-α-L-fucopyranosyl-j8-D-galactopyranosyl-4-α-L-fucopyranosyl- j8-D-glucopyranoside (55) and acrylamide. To acrylamide (8.3 mg, 120 μmol) was added at room temperature a solution of tetrasaccharide (54) (15 mg, 20 μmol) in deaerated water (1 ml) . To this slowly stirred solution (kept in the dark and under nitrogen atmosphere was added at 0°C, first N,N,N',N'-tetramethylethylenediamine (6 μl) , and then ammonium persulphate (3.5 mg) . The mixture was stirred at room temperature over night. TLC (ethyl acetate:acetic acid:methanol :water 5:3:2) showed that all of compound (49) was consumed and that a charring baseline product had been formed. The polymer was purified by gel chromatography on a Bio-Gel* P-2 column SUBSTITUTESHEET eluted with aqueous.n-butanol (1%). Freeze-drying of the polymeric fraction eluted in the void volume gave 20 mg of polymer (56) . A ^-NMR analysis of the product showed an average incorporation of 1 trisaccharide per 6 acrylamide units. EXAMPLE 13 Fucαl-2 Gal/Sl-O-spacer 5-PAA (58 I)] (i) 2-acrylamidoethyl 2-0-α-L-fucopyranosyl-0-D- galactopyranoside (57) 0.3 ml deaerated 0.5 M sodiumborate (aq) buffer (pH 8.5) and methanol (0.9 ml) was added to 6.4 mg of the compound (30). The reaction mixture was flushed with nitrogen and cooled to 0°c. 2 μl acryloyl chloride was added and stirring was continued for 10 minutes. The reaction mixture was concentrated at room temperature to about a third of its original volume. Purification on a Bio-Gel* P2 column and lyophilization gave the compound (57) (4 mg, 57%) . NMR-data: ~R (D 2 0) : δ 1.2 (d, CH 3 fucose) 4.52 (dd, H-l), 5.22 (m, H-l'), 5.80 (dd, CH=CH 2 ) , 6.25 (m, CH=CH 2 ) . (ii) Fucαl-2 GalSl-O-spacer 5-PAA (58) To a solution of the compound (57) (4 mg, 9 μmol) and acrylamide (3.3 mg, 47 μmol) in deaerated water (0.75 ml) was added first N,N,N',N'-tetramethylenediamine (2 μl) and then ammonium persulphate (1.5 mg) . The mixture was stirred at room temperature over night. The polymer (58) was purified on a Bio- Gel* P2 column (9.1 mg) . NMR-data: *H (D 2 0) showed an average incorporation of 1 oligosaccharide per 12.3 acrylamide units. SUBSTITUTE SHEET BIOLOGICAL EXPERIMENTS Materials and Methods In situ adherence assay for Helicobacter pylori Non-infected samples from normal adult human gastric tissue (obtained from Huddinge Sjukhus, Sweden) were used to study Helicobacter pylori adherence. All samples were fixed in 4% formalin and subsequently embedded in paraffin. Sections, 4 μm thick, were placed on glass slides and used for Steiner's silver staining (to identify the cell types present in gastric units, and to verify that the tissue samples have no pathologic changes) and/or subsequent adherence assay. Four clinical isolates, A4, A5, A7, and A8 (obtained from Huddinge Sjukhus) of Helicobacter pylori were used. Helicobacter pylori was cultured at 37°C on Brucella Agar supplemented with 10% bovine blood and 1% IsoVitalex (Becton Dickinson Microbiology System, Cockeyville, MD) under microaerophilic conditions (5% 0 2 , 10% C0 , 85% N 2 ) and 98% humidity. Five days after inoculation, bacteria from one full-grown plate were resuspended by gentle pipetting in 25 ml of 0.1M NaCl/ 0.1M sodium carbonate, pH 9.0. 250 μl of a freshly prepared 10 mg/ml solution of fluorescein isothiocyanate (FITC, Sigma Chemical Co.) in dimethylsulfoxide was added to the suspension of bacteria which was then incubated for 1 hour at room temperature in the dark. The bacteria were recovered by centrifugation at 3000 x g for 10 minutes, and then resuspended in phosphate buffered saline (PBS) + 0.05% polyoxyethylene sorbitan monolaurate (Tween 20) by gentle pipetting and subsequently pelleted by centrifugation as above. The wash procedure was repeated 3 times and the suspension was finally resuspended to an Optical Density of 0.2. The intensity of FITC-labelling of all bacterial strains was similar as judged by inspection of comparable numbers of organisms by fluorescence microscopy. Aliquots of 1 ml were SUBSTITUTESHEET taken from the final suspensions and utilized immediately or stored at -20°C until use. No difference in binding pattern was observed between strains labelled and used immediately and strains that were frozen and thawed once before use. Slide-mounted tissue sections were deparaffinized in Bio-Clear (Bio-Optica SpA) and absolute alcohol, 95% alcohol followed by 70% alcohol, rinsed in water followed by PBS and then incubated for 45 minutes in blocking buffer (1% gelatin/0.05% Tween 20 in PBS). FITC labelled bacterial suspension (OD about 0.200-0.250) was mixed with equal amount of a concentrated solution of the compound. The mixture was preincubated for 2 hours at room temperature in the dark, 200 μl of the mixture was placed on a slide-mounted tissue section and incubated for 1 hour at room temperature in a humidified chamber. The slides were subsequently washed 6 times with PBS prior to inspection under fluorescence microscope. Analysis The in situ adherence assay was used to ascertain binding of Helicobacter pylori to human gastric tissue and to demonstrate inhibition of Helicobacter pylori with terminal L-fucose-containing compounds, e.g. LNF1-HSA. To analyze the ability of terminal L-fucose-containing compounds to inhibit binding. FITC labelled bacterial suspension (O.D. about 0.200-0.250) was mixed with equal amount of a concentrated solution of the compound. The mixture was preincubated for 2 hours at room temperature in the dark. 200μl of the mixture was placed on a slide-mounted tissue section and was incubated for 1 hour at room temperature. After incubation, the treated tissue sections were washed 6 times with PBS before analysis of the tissue sections. Comparison tissue sections treated with test compound with untreated tissue sections using fluorescence microscopy and image analysis (Neotech Image Grabber 24/1.1 to transfer the SUBSTITUTESHEET visual microscope image to a computer screen and Optilab 24/2.1.1 Grafted, to count the adhered bacteria). The given values in the table are the average number of adhered bacteria on three different areas per section comparing treated (with compound) with untreated tissue sections. SUBSTITUTESHEET Table COMPOUND CONC INHIB (average value) [ Fucαl-2Gal/3l-spacer 1 ] 5 -HSA 2 mM 34% [Fucαl-2Gal/8l-spacer 4 ] 8 -HSA 2 mM 35% [Fucαl-2Gal/8l-spacer 2 ] n -PAA 2 mM 45% n=l per 12.3 acrylamide moieties [Fucαl-2Gal/3l-spacer 5] . j -PAA 1 mM 53% n=l per 5 acrylamide moieties [Fucαl-2Gal/8l-3GlcNAcj8l-spacer 2 ] n -PAA 2 mM 40% n=l per 7. 6 acrylamide moieties [Fucαl-2Gal/Sl-3GlcNAc/8l-Gal/3l-spacer 3 ] 35 - -HSA (LNF1-HSA) 0.2 mM 72% (Purchased from Iso Sep AB, Sweden) [Fucαl-2Gal/8l-3(Fucαl-4)GlcNAc/3l-Gal/3l- -spacer 3] 32 -HSA (LND1-HSA) 0.2 mM 71% (Purchased from Iso Sep AB, Sweden) [Fucαl-2Gal / 8l-3Fucαl-4)GlcNac / Sl-Galβl- -spacer 3] n -PAA n=l per 18 acrylamide moieties 0.2 mM 67% n=l per 5 acrylamide moieties 0.2 mM 84% n=l per 6 acrylamide moieties 0.2 mM 93% [GalNAcαl-3 (Fucαl-2) Gal/3l-3 (Fucαl-4 ) - 0.2 mM 80% GlcNac/Sl-Gal/?l-spacer 3 ] 22 -HSA (A-hepta-HSA) (Purchased from Iso Sep AB, Sweden) SUBSTITUTE SHEET

Claims: CLAIMS 1. Use of a compound of the general formula la, lb, Ic, Id, Ie or If Y-Z,-R A-Z 2 -R A-Z,-B-Z Λ -R la lb Ic A-Z 5 -B-Z 6 -C-Z 7 -R A-Zg-B-Zg-C-Zi Q -D-Zii-R Id Ie A-Z '1 1 2 9 -B-Z,-,-C-Z 1 1 4 il - • Dυ-—Zit 1 1 5.;- ' E-Z 1-| ft 6-R If wherein lf Z 2 , Z 3 , Z 4 , Z 5 , Z 6 , Z 7 , Z 8 , Zg, z 10 , Zιι, z 12 , z 13 , z 14 , z 15 and Z 16 independently are 0, S, CH 2 , or NR 2S , where R 25 is hydrogen, C 1 _ 4 -alkyl, c 2 _ 24 -alkenyl, C 1 _ 24 -alkylcarbonyl, or benzoyl optionally substituted with hydroxy, amino, C 1-4 -alkyl, C 1 _ 4 -alkoxy, nitro, halogen, phenoxy, or mono- or di-halogen-C 1 _ -alkyl; SUBSTITUTE SHEET wherein the wavy line in Y, A, B, C, D and E signifies a bond which is either in the α- or in the /S-configuration; R 1# R 2 , and R 3 each independently are H, halogen, azido, guanidinyl, branched or unbranched C 1 _ 24 -alkyl, C 2 _ 24 -alkenyl, C 2 _ 2 -alkynyl, C 3 _ 8 -cycloalkyl, C 3 _ 8 -cycloalkyl-C 1 _ 24 -alkyl, or C 1 _ 1 -alkoxy-C 1 _ 12 -alkyl group which is optionally substituted with hydroxy, amino, halogen, or oxo; aryl or aryl-C j ^-alkyl optionally substituted in the aryl moiety with hydroxy, amino, C i ^-alkyl, C j _ 4 -alkoxy, nitro, halogen, phenoxy, or mono- or di-halogen-C 1 _ 4 -alkyl; trifc^-alkyljsilylethyl; oxo; a group =CR 4 R 5 wherein R 4 and R 5 independently are H, or C^-alkyl; or a group XR 10 wherein X is 0, S, NR 20 , or =N-, and R 10 is H, branched or unbranched C 1 _ 2 -alkyl, C 2 _ 24 -alkenyl, C _ 24 -alkynyl, C 3 _ 8 -cycloalkyl, C 3 _ 8 -cycloalkyl-C 1 _ 2 -alkyl, or C 1 _ 12 -alkoxy-C 1 _ 12 -alkyl group which is optionally substituted with hydroxy, amino, halogen, or oxo; aryl, aryl-C j ^-alkyl, or heterocyclyl-C 1 _ 4 -alkyl optionally substituted in the aryl or heterocyclyl moiety with hydroxy, amino, C 1 _ 4 -alkyl, C^-alkoxy, nitro, halogen, phenoxy, or mono- tri^^ alkyl)silylethyl; trifC j ^-alkylJsilyl; tri(C 1 _ -alkyl)silylethoxymethyl; the acyl residue of a naturally occurring amino acid; C 1 _ 2 -alkylcarbonyl; C 2 _ 24 -alkenylcarbonyl; C 3 _ 8 -cycloalkyl-C 1 _ 4 -alkylcarbonyl; arylcarbonyl; or terpenyl; and R 0 is H, C 1 _ 24 -alkyl, C 2 _ 24 -alkenyl, C 1 _ 2 -alkylcarbonyl, or benzoyl or phthaloyl optionally substituted in the benzene ring with hydroxy, amino, C 1 _ 4 -alkyl, C 1 _ 4 -alkoxy, nitro, halogen, phenoxy, or mono- or di-halogen-C j ^-alkyl; SUBSTITUTESHEET R 1A ' R 2A ' R 3A ' R 4A ' R 1B ' R 2B ' R 3B ' R 4B ' R 1C R 2C R 3C R 4C 1D ' R 2D ' R 3D ' R 4D » R 1E ' R 2E ' R 3E » anc * R 4E eacn independently is as defined for R lf R , and R 3 above, or is a group of the formula VII YZ α VII wherein Y and Z are as defined above; with the provisos that one of R 1B , R 2B , R 3B , or R 4B is Z 3 , Z 5 , Z 8 or Z 12 , that one of R lc , R 2C , R 3C , or R C is Z 6 , Z 9 or Z 13 , that one of R 1D , R 2D , R 3D , or R 4D is Z 10 , or Z 14 , that one of R 1E , R 2E , R 3E , or R 4E is Z 15 , that at least one and at the most five of R 1A , R 2A , R 3A , R 4A» R 1B' R 2B' R 3B» R 4B» 1C» 2C 3C 4C R 1D' R 2D» 3D' R 4D , R 1E , R 2E , R 3E , and R E is a group of the formula VII, and that the configurations of the substituents R 1A , R 2A , R 3A , and R 4A CH 2 in A, the configurations of the substituents R 1B , R 2B , R 3B# and R 4B CH 2 in B, the configurations of the substituents R lc , R 2C , R 3C , and R C CH in C, the configurations of the substituents R 1D , R 2D , R 3D , and R D CH 2 in D, and the configurations .of the substituents R 1E , R 2E , R 3E , and R 4E CH in E independently are D-gluco, L-gluco, D-galacto, L-galacto, D-manno, L-manno, D-talo, L-talo, D-allo, L-allo, D-altro, L-altro, D-gulo, L-gulo, D-ido, or L-ido; R is hydrogen, a branched or unbranched C 1 _ 2 -alkyl, C 2 _ 24 -alkenyl, C 2 _ 24 -alkynyl, C 3- . 8 -cycloalkyl, C 3 _ 8 -cycloalkyl-C 1 _ 4 -alkyl, C 1 _ 12 -alkoxy-C 1 _ 12 -alkyl, C 1 _ 24 -alkylcarbonyl, C 2 _ 24 -alkenylcarbonyl, or C 3 _ 8 -cycloalkyl-C 1 _ 24 -alkylcarbonyl group which is optionally substituted with hydroxy, amino, halogen, or oxo; an aryl, aryl-C j ^-alkyl, arylcarbonyl or aryl-C 1 _ 4 -alkylcarbonyl group optionally substituted in the aryl moiety with hydroxy, amino, C 1 _ 4 -alkyl, C j ^-alkoxy, nitro, halogen, phenoxy, or mono- or SUBSTITUTESHEET di-halogen-C 1 _ -alkyl ; terpenyl ; tri f C j ^-alkylJ silylethyl ; heterocyclyl ; heterocyclyl-C-^-alkyl ; or heterocyclyl-C 1 _ 4 -alkylcarbonyl ; a group of the formula II or Ila R 30- ( C H2) q-S (O) m -CH 2 CH 2 - II [R 30 - (CH 2 ) q -S (O) m -CH 2 ] 2 CH-CH 2 - Ila wherein R 30 is H, carboxy, C 1 _ 4 -alkoxycarbonyl, hydroxy, amino, or a matrix MA, q is an integer from 1 to 24, and m is 0 or 2; or a group of the formula III or Ilia Phe-S(0) m -CH 2 CH 2 - III [Phe-S(0) m -CH 2 ] 2 CH-CH 2 - Ilia wherein m is as defined above, and each Phe is phenyl optionally substituted with hydroxy, amino, C 1 _ -alkyl, C 1 _ -alkoxy, nitro, halogen, phenoxy or mono- or di-halogen C 1 _ 4 -alkyl; or phenyl-C j ^-alkyl optionally monosubstituted in the phenyl moiety with hydroxy, amino, C α _ 4 -alkyl, C 1 _ -alkoxy, nitro, halogen, phenoxy, or mono- or di-halogen-C 1 _ 4 -alkyl; a group of the formula IV R 40 CH 2 CH(CH 2 R S0 )CH 2 - IV wherein R 40 and R 50 independently are halogen; or a group Q-(Spacer) r -, where r is an integer 0 or 1 and Q is a matrix MA or a group -COO-MA; SUBSTITUTESHEET for the preparation, of a pharmaceutical composition for the treatment or prophylaxis in humans of conditions involving infection by Helicobacter pylori of human gastric mucosa. 2. Use according to claim 1 in which Z λ , Z 2 , Z 3 , Z 4 , Z 5 , Z 6 , Z 7 , Z 8 , Zg, Z 10 , ^i i .' ^ι 2 , Z 13 , Z 14 , Z i5 and Z 16 are 0. 3. Use according to claim 1 or 2 in which at the most four, preferably at the most three, in particular one or two of R 1A , R 2A' R 3A» R 4A' R 1B» R 2B' R 3B' R 4B' R 1C R 2C R 3C R 4C R 1D' R 2D' 3D' R 4D' R i E » R 2E » R 3E or R 4E is a group of formula VII. 4. Use according to any of claims 1-3 in which R 1A is a group VII in the α-configuration. 5. Use according to any of claims 1-3 in which the configuration of R 1A , R 2A , R 3A and R A CH in A are D-galacto, A being in the /3-configuration. 6. Use according to any of claims 1-3 in which R 1A is a group VII in the α-configuration and the configuration of R 1A , R 2A , R 3A and R 4A CH in A are D-galacto, A being in the 0-configuration. 7. Use according to any of claims 1-3 in which R 2B is Z 3 , Z 5 , z 8 , or Z 12 , and the configuration of R 1B , R 2B , R 3B , and R 4B CH 2 in B are D-gluco, B being in the /3-configuration. 8. Use according to any of claims 1-3 in which R 1B is an acetamido group. 9. Use according to any of claims 1-3 in which R 1A is a group VII in the α-configuration; the configuration of R 1A , R 2A , R 3A and R 4A CH 2 in A are D-galacto, A being in the /8-configuration; R 2B is Z 3 , Z 5 , Z 8 , or Z 1 ; and the configuration of R 1B , R 2B , R 3B , and R 4B CH 2 in B are D-gluco, B being in the /8-configuration and R 1B is an acetamido group. SUBSTITUTESHEET 10. Use according to any of claims 1-9 in which R 3B is a group o the formula VII in the α-configuration. 11. Use according to any of claims 1-10 in which the configurations of R 1A , R 2A , R 3A , and R 4A CH 2 in A and of R 1B , R 2B , R 3B , and R 4B CH 2 in B are D-galacto, and the configurations of R l R 2c» R 3 c and R 4 c CH 2 in c are D-g luco # A be ng in the α-configuration, and B and C being in the jS-configuration, and in which R 1B and R 3C are groups of the formula VII in the α-configuration, and in which R 1A and R lc are acetamido groups, and R 2B is Z 5 , Z 8 or Z 12 , and R 2C is Z 6 , Z 9 or Z 13 . 12. Use according to claim 6 in which A is Fucαl-2Gal/3. 13. Use according to claim 9 in which A-Z 3 -B is Fucαl-2Gal/3l-3GlcNAc/3; or Fucαl-2Gal/3l-3(Fucαl-4)GlcNAc/3. 14. Use according to claim 9 in which A-Z 5 -B-Z 6 -C is Fucαl-2Gal/3l-3GlcNAc/5l-3Gal/3; or Fucαl-2Gal/3l-3(Fucαl-4)GlcNAc/3l-3Gal/3. 15. Use according to claims 9 or 11 in which A-Z 8 -B-Z 9 -C-Z 10 -D i GalNAcαl-3(Fucαl-2)Gal/Sl-3(Fucαl-4)GlcNAc/Sl-3Gal3; or Fucαl-2Gal/3l-3(Fucαl-4)GlcNAc/3l-3Gal/Sl-4Glc3. 16. Use according to claim 11 in which A-Z 12 -B-Z 13 -C-Z 14 -D-Z 15 -E is GalNAcαl-3(Fucαl-2)Gal/3l-3(Fucαl-4)GlcNAc/Sl-3Gal/3l-4Glc/3. 17. Use according to any of claims 1-16 in which R is a group Q-(Spacer) r -, where r is an integer 0 or 1 and Q is a matrix MA. SUBSTITUTESHEET 18. Use according to any of claims 1-17 in which the Spacer is defined (W) v -S'-P', wherein S' is an C^^ alkyl, an C 2 _ 24 alkenyl, an C 1 _ 4 alkylaryl, an arylC 1 _ 24 alkyl an arylC- L . 24 alkylaryl, an C 1 _ 24 alkylarylC 1 _ 24 alkyl group which groups may be interrupted by carbonyl, thiocarbonyl, oxycarbonyl, carbonyloxy, carbonylamino, aminocarbonyl, aza, oxa or thia groups; an aryl group, an aryloxy, an C 1 _ 24 alkoxy, a polyethyleneglycol group, a steroid group, a sphingoid group; all groups may be substituted with carboxyl, C j ^alkylcarbonyl, amide, hydroxy, alkoxy, aryloxy, phenoxy; P' is NH-C(S), NH-C(O), C(O) , NH, C(S) , C(0)0, (O)CO, SO, S0 2 , S0 3 , S0 4 , P0 3 , P0 4 ; W is NH-C(S), NH-C(O), C(0) , C(S), C(0)0, (0)C0, SO, S0 2 , S0 3 , S0 4 , P0 2 , P0 3 , P0 4 , with the proviso that when Z x , Z 2 , Z 4 , Z 7 , Z or Z 16 are CH 2 then W cannot be P0 2 , with the proviso that when Z λ , Z 2 , Z 4 , Z 7 , Z n or Z 16 are O or S then W cannot be (O)CO, S0 4 or P0 4 , and with the proviso that when Z 2 , Z 2 , Z , Z 7 , Z λl or Z 16 are NH then W cannot be NH-C(S), NH-C(O), (O)CO, S0 4 , P0 4 ; and v is an integer 0 or 1. 19. Use according to any of claim 18 in which the spacer is selected from spacer 1 spacer 2 spacer 3 spacer 4 SUBSTITUTE SHEET 20. Use according to claims 1-17 in which MA is HSA, BSA or PAA. 21. Use according to claim 1 in which the compound is selected from [Fucαl-2Gal/3l-Spacer] n -MA; [Fucαl-2Gal/3l-3GlcNAc/S-Spacer] n -MA; [Fucαl-2Gal/3l-3(Fucαl-4)GlcNAqS-Spacer] n -MA; [Fucαl-2Gal/3l-3GlcNAc3l-3Gal/Sl-Spacer] n -MA; [Fucαl-2Gal/Sl-3(Fucαl-4)GlcNAc/3l-3Gal/3l-Spacer] n -MA; [GalNAcαl-3(Fucαl-2)GaljSl-3(Fucαl-4)GlcNAc01-3Gal/3l-Spacer] n -MA; [Fucαl-2Gal/3l-3(Fucαl-4)GlcNAc/Sl-3GaljSl-4Glc/8l-NH] n MA; (GalNAcαl-3(Fucαl-2)Gal/3l-3(Fucαl-4)GlcNAq8l-3Gal/8l-4Glc/3l- Spacer] n -MA; wherein the Spacer is selected from the group defined in claim 19, n is an integer 1-40 when MA is HSA or BSA, and n is an interger 10-10000 when MA is PAA. 22. Use according to claim 1 in which the compound is selected from [Fucαl-2Gal/8l-Spacer l] n -HSA; [Fucαl-2Gal/8l-Spacer 2] n -PAA; [Fucαl-2Gal01-Spacer 4] n -HSA; [Fucαl-2Gal/3l-Spacer 5] n -PAA; [Fucαl-2Gal/5l-3GlcNAc/S-Spacer 5] n -PAA; [Fucαl-2Gal01-3(Fucαl-4)GlcNAc/S-Spacer 5] n -PAA; [Fucαl-2Gal/8l-3GlcNAc/8l-3Gal/Sl-Spacer 3] n -HSA; [Fucαl-2Gal/8l-3(Fucαl-4)GlcNAc/Sl-3Gal01-Spacer 3] n -HSA; [Fucαl-2Gal/8l-3(Fucαl-4)GlcNAc/5l-3Gal/3l-4Glc/Sl-NH] n -PAA; (GalNAcαl-3(Fucαl-2)Gal/3l-3(Fucαl-4)GlcNAc/3l-3Gal/8l-Spacer 3] n - -HSA; wherein Spacer 1, Spacer 2, Spacer 3, Spacer 4 and Spacer 5 are defined as in claim 19 and n is an integer 1-40 when MA is HSA, and n is an interger 10-10000 when MA is PAA. 23. Use according to any of claims 1-22 wherein the compound of formula la, lb, Ic, Id, Ie or If is adapted to be administered in combination with a preparation for standard therapy of gastritis or ulcus, especially preparations containing SUBSTITUTESHEET omeprazole, cimetidine, ranitidine, lansoprazole, pantoprazole, sucralfate, famotidine, nizetidine, magnesium hydroxide, aluminium hydroxide, calcium carbonate, simethicone or magaldrate. 24. Use according to any of claims 1-23 wherein the compound of formula la, lb, Ic, Id, Ie or If is edapted to be administered in combination with a preparation for a course of therapy with an antimicrobial agent, especially preparations containing: /8-lactam antibiotics such as amoxicillin, ampicillin, cephalothin, cefaclor or cefixime; or macrolides such as erythromycin, or clarithromycin; or tetracyclines such as tetracycline or doxycycline; or aminoglycosides such as gentamycin, kanamycin or amikacin; o quinolones such as norfloxacin, ciprofloxacin or enoxacin; o others such as metronidazole, nitrofurantoin or chloramphenicol; or preparations containing bismuth salts such as bismuth subcitrate, bismuth subsalicylate, bismuth subcarbonate, bismuth subnitrate or bismuth subgallate. 25. A method of treating and/or preventing diseases in humans caused by infection by Helicobacter pylori of human gastric mucosa, said method comprising administering to a patient in need thereof an effective amount of a compound of the formula la, lb, Ic, Id, Ie or If as defined in claims 1-22. 26. A method of treating and/or preventing diseases in humans caused by infection by Helicobacter pylori of human gastric mucosa, said method comprising administering to a patient in need thereof an effective amount of a compound of the formula la, lb, Ic, Id, Ie of If as defined in claims 1-22 in combination with at least one anti-ulcer or anti-gastritis medicament, or with at least one antimicrobial agent, or with mixtures thereof. SUBSTITUTESHEET 27. A pharmaceutical composition comprising a compound of the formula la, lb, Ic Id, Ie or If as defined in claims 1-22 or a mixture of such compounds, in combination with at least one anti-ulcer or anti-gastritis medicament, or with at least one antimicrobial agent, or with mixtures thereof, and with a pharmaceutically acceptable carrier. 28. A pharmaceutical composition according to claim 27 in which the anti-ulcer or anti-gastritis medicament is selected from a gastric secretion inhibiting compound and an antacid. 29. A pharmaceutical composition according to claim 28 in which the gastric secretion inhibiting compound is selected from cimetidine, ranitidine, famotidine, nizatidine, omeprazole, lansoprazole, pantoprazole, and sucralfate. 30. A pharmaceutical composition according to claim 28 in which the antacid is selected from A1(0H) 3 , Mg(OH) 2 , CaC0 3 , Na 2 C0 3 , NaHC0 3 , aluminium magnesium hydroxide or its hydrate, simethicone. 31. A pharmaceutical composition according to claim 27 in which the antimicrobial agent is selected from /3-lactam antibiotics such as amoxicillin, ampicillin, cephalothin, cefaclor or cefixime; macrolides such as erythromycin or clarithromycin; tetracyclines such as tetracycline or doxycycline; aminoglycosides such as gentamycin, kanamycin or amikacin; quinolones such as norfloxacin, ciprofloxacin or enoxacin; bismuth salts such as bismuth subcitrate, bismuth subsalicylate, bismuth subcarbonate, bismuth subnitrate or bismuth subgallate; heterocyclic antibiotics such as metronidazole or nitrofurantoin; and benzene derivatives such as chloramphenicol. 32. Novel compounds of the general formula la, lb, Ic, Id, Ie or If SUBSTITUTESHEET Y-Z,-R A-Z 2 -R A-Z,-B-Z Δ -R la lb Ic A-ZC-B-ZA-C-Z-7-R A-ZO-B-ZQ-C-Z I 1 n 0-D-Z '1ι1,-R Id Ie A-Z 12 -B-Z 13 -C-Z 14 -D-Z 15 -E-Z 16 -R If wherein Z lf Z 2 , Z 3 , Z 4 , Z 5 , Zg, Z 7 , Z 8 , Zg, Z 10 , 2 llf Z 12 , Z 13 , Z 14 , Z 15 and Z 16 independently are O, S, CH 2 , or NR 25 , where R 25 is hydrogen, C 1- . 24 -alkyl, C 2 _ 2 -alkenyl, C 1 _ 2 -alkylcarbonyl, or benzoyl optionally substituted with hydroxy, amino, C 1 _ -alkyl, C j ^-alkoxy, nitro, halogen, phenoxy, or mono- or di-halogen-C 1 _ 4 -alkyl; SUBSTITUTE SHEET wherein the wavy line in Y, A, B, C, D and E signifies a bond which is either in the α- or in the ,5-configuration; R lf R 2 , and R 3 each independently are H, halogen, azido, guanidinyl, branched or unbranched C 1 _ 24 -alkyl, C 2 _ 24 -alkenyl, C 2 _ 24 -alkynyl, C 3 _ 8 -cycloalkyl, C 3 _ 8 -cycloalkyl-C 1 _ 24 -alkyl, or C 1 _ 12 -alkoxy-C 1 _ 12 -alkyl group which is optionally substituted with hydroxy, amino, halogen, or oxo; aryl or aryl-C 1- . 4 -alkyl optionally substituted in the aryl moiety with hydroxy, amino, C 1 _ 4 -alkyl, C 1- . 4 -alkoxy, nitro, halogen, phenoxy, or mono- or di-halogen-C 1 _ -alkyl; triJC j ^-alkylJsilylethyl; oxo; a group =CRR 5 wherein R 4 and R s independently are H, or C 1 . 4 -alkyl; or a group XR 10 wherein X is 0, S, NR 20 , or =N-, and R 10 is H, branched or unbranched C 1 . 24 -alkyl, C 2 _ 2 -alkenyl, C 2 _ 24 -alkynyl, C 3 _ 8 -cycloalkyl, C 3- . 8 -cycloalkyl-C 1- . 2 -alkyl, or C 1 _ 12 -alkoxy-C 1 _ 12 -alkyl group which is optionally substituted with hydroxy, amino, halogen, or oxo; aryl, aryl-C j ^-alkyl, or heterocyclyl-C 1 _ -alkyl optionally substituted in the aryl or heterocyclyl moiety with hydroxy, amino, C^-alkyl, C^-alkoxy, nitro, halogen, phenoxy, or mono- or di-halogen-C 1- . 4 -alkyl; tri(C 1- . 4 alkyl)silylethyl; tri(C 1 _ 4 -alkyl)silyl; trifC j ^-alkylJsilylethoxymethyl; the acyl residue of a naturally occurring amino acid; C 1 _ -alkylcarbonyl; C 2 _ 24 -alkenylcarbonyl; C 3 _ 8 -cycloalkyl-C 1 _ 24 -alkylcarbonyl; arylcarbonyl; or terpenyl; and R 20 is H, C 1 _ 24 -alkyl, C 2- . 24 -alkenyl, C 1 _ 24 -alkylcarbonyl, or benzoyl or phthaloyl optionally substituted in the benzene ring with hydroxy, amino, C 1 _ -alkyl, C 1 _ 4 -alkoxy, nitro, halogen, phenoxy, or mono- or di-halogen-C 1 _ 4 -alkyl; SUBSTITUTESHEET R 1A ' R 2A' R 3A ' R 4A ' R 1B ' R 2B ' R 3B ' R 4B ' R 1C R 2C R 3C R 4C 1D ' R 2D ' R 3D » R 4D ' 1E ' 2E ' R 3E ' and R 4E eac " independently is as defined for R lr R 2 , and R 3 above, or is a group of the formula VII YZ 2 VII wherein Y and Z 1 are as defined above; with the provisos that one of R 1B , R 2B , R 3B , or R 4B is Z 3 , Z 5 , Z 8 or Z 12 , that one of R lc , R C , R 3C , or R C is Z 6 , Z 9 or Z 13 , that one of R 1D , R 2D , R 3D , or R 4D is Z 10 , or Z 14 , that one of R 1E , R 2E , R 3E , or R 4E is Z 15 , that at least one and at the most five of R 1A , R 2A , R 3A , 4A' R 1B» R 2B' 3B' R 4B ' R 1C 2C R 3C R 4C R 1D ' R 2D » R 3D » R 4D R i E ' R 2E ' R 3E ' and R 4E is a group of the formula VII, and that the configurations of the substituents R 1A , R 2A , R 3A and R 4A CH 2 in A, the configurations of the substituents R 1B , R 2B , R 3B , and R 4B CH 2 in B, the configurations of the substituents R lc , R 2C , R 3C , and R 4C CH 2 in C, the configurations of the substituents R 1D , R 2D , R 3D , and R CH 2 in D, and the configurations of the substituents R 1E , R 2E , R 3E , and R E CH 2 in E independently are D-gluco, L-gluco, D-galacto, L-galacto, D-manno, L-manno, D-talo, L-talo, D-allo, L-allo, D-altro, L-altro, D-gulo, L-gulo, D-ido, or L-ido; is hydrogen, a branched or unbranched C 1 _ 24 -alkyl, C 2 _ 24 -alkenyl, C 2 _ 24 -alkynyl, C 3 _ 8 -cycloalkyl, C 3- . 8 -cycloalkyl-C 1 _ 24 -alkyl, C 1- . 12 -alkoxy-C 1 _ 12 -alkyl, C 1 _ 24 -alkylcarbonyl, C 2 _ 24 -alkenylcarbonyl, or C 3- _ 8 -cycloalkyl-C 1 _ 2 -alkylcarbonyl group which is optionally substituted with hydroxy, amino, halogen, or oxo; an aryl, aryl-C 1 _ 4 -alkyl, arylcarbonyl or aryl-C 1 _ 4 -alkylcarbonyl group optionally substituted in the aryl moiety with hydroxy, amino, C 1 _ -alkyl, C j ^-alkoxy, nitro, halogen, phenoxy, or mono- or SUBSTITUTESHEET di-halogen-C 1 _ 4 -alkyl ; terpenyl ; tri (C2_ 4 -alkyl) silylethyl ; heterocyclyl ; heterocyclyl-C j ^-alkyl ; or heterocyclyl-C^-alkylcarbonyl ; a group of the formula II or Ila R 3 0- (CH 2 ) q -S (O) m -CH 2 CH 2 - II [R 30 - (CH 2 ) q -S (O) m -CH 2 ] 2 CH-CH 2 - Ila wherein R 30 is H, carboxy, C 1 _ 4 -alkoxycarbonyl, hydroxy, amino, or a matrix MA, q is an integer from 1 to 24, and m is 0 or 2; or a group of the formula III or Ilia Phe-S(0) m -CH 2 CH 2 - HI [Phe-S(0) m -CH 2 ] 2 CH-CH 2 - Ilia wherein m is as defined above, and each Phe is phenyl optionally substituted with hydroxy, amino, nitro, halogen, phenoxy or mono- or di-halogen C 1-4 -alkyl; or pheny1-^. 4 -alkyl optionally monosubstituted in the phenyl moiety with hydroxy, amino, nitro, halogen, phenoxy, or mono- or di-halogen-C 1 _ -alkyl; a group of the formula IV R 40 CH 2 CH(CH 2 R 50 )CH 2 - IV wherein R 0 and R 50 independently are halogen; or a group Q-(Spacer) r -, where r is an integer 0 or 1 and Q is a matrix MA or a group -COO-MA. 33. Novel compounds according to claim 32 in which Z l t Z 2 , Z 3 , Z 4 , Z 5 , Z 6 , Z 7 , Z 8 , Zg, Z 10 , Zn , Z 12 , Z 13 , Z 14 , Z 15 and Z 16 are 0. SUBSTITUTESHEET 34. Novel compounds according to any of claims 1 or 2 in which at the most four, preferably at the most three, in particular one or two of R 1A , R 2A , R 3A » R 4A , R IB» R 2B' R 3B» R 4B» R IC R 2C R 3C 4C R 1D' R 2D' R 3D» R 4D' R 1E' R 2E' R 3E or R 4E is a group of formula VII. 35. Novel compounds according to any of claims 32-34 in which R 1A is a group VII in the α-configuration. 36. Novel compounds according to any of claims 32-34 in which the configuration of R 1A , R 2A , R 3A and R 4A CH 2 in A are D-galacto, A being in the ,5-configuration. 37. Novel compounds according to any of claims 32-34 in which R 1A is a group VII in the α-configuration and the configuration of R 1A' R 2A* R 3 A and R 4A CH 2 in A are D-galacto, A being in the /8-configuration. 37. Novel compounds according to any of claims 32-34 in which R 2B is Z 3 , Z 5 , Z 8 , or Z 12 , and the configuration of R 1B , R 2B , R 3B , and R 4B CH 2 in B are D-gluco, B being in the /S-configuration. 39. Novel compounds according to any of claims 32-34 in which R 1B is an acetamido group. 40. Novel compounds according to any of claims 32-34 in which R 1A is a group VII in the α-configuration; the configuration of R 1A , R 2A , R 3A and R A CH 2 in A are D-galacto, A being in the 3-configuration; R 2B is Z 3 , Z 5 , Z 8 , or Z 12 ; and the configuration of R 1B , R 2B , R 3B , and R B CH 2 in B are D-gluco, B being in the ,3-configuration and R 1B is an acetamido group. 41. Novel compounds according to any of claims 32-40 in which R 3B is a group of the formula VII in the α-configuration. 42. Novel compounds according to any of claims 32-41 in which the configurations of R 1A , R 2A , R 3A , and R 4A CH 2 in A and of R 1B , R 2B ' R 3B ' and R 4B CH 2 in B are D-galacto, an( j the configurations of SUBSTITUTESHEET R ιc/ R 2 c R 3 c and R 4 c CH 2 in c are D-gluco, A being in the α-configuration, and B and C being in the /3-configuration, and in which R 1B and R 3C are groups of the formula VII in the α-configuration, and in which R 1A and R lc are acetamido groups, and R 2B is Z 5 , Z 8 or Z 12 , and R 2C is Z 6 , Z 9 or Z 13 . 43. Novel compounds according to claim 37 in which A is Fucαl- 2Gal/3. 44. Novel compounds according to claim 40 in which A-Z 3 -B is Fucαl-2Gal/Sl-3GlcNAc/3; or Fucαl-2Gal/3l-3(Fucαl-4)GlcNAqS. 45. Novel compounds according to claim 40 in which A-Z 5 -B-Z 6 -C is Fucαl-2Gal/3l-3GlcNAc/3l-3Gal/3 ; or Fucαl-2Gal/3l-3 (Fucαl-4 ) GlcNAc/3l-3Gal/3. 46. Novel compounds according to claims 40 or 42 in which A-Z 8 -B- Z 9 -C-Z 10 -D is GalNAcαl-3 (Fucαl-2 ) Gal/Sl-3 (Fucαl-4) GlcNAc/3l-3Gal/S; or Fucαl-2Gal/8l-3 (Fucαl-4 ) GlcNAc/3l-3Gal£l-4Glc/8. 47 . Novel compounds according to claim 42 in which A-Z 12 -B-Z 13 -C- Z 1 -D-Z 15 -E is GalNAcαl-3 (Fucαl-2 ) Gal/3l-3 (Fucαl-4) GlcNAc/3l-3Gal/8l-4Glc/S. 48 . Novel compounds according to any of claims 32-47 in which R is a group Q- (Spacer) r -, where r is an integer 0 or 1 and Q is a matrix MA. 49. Novel compounds according to any of claims 32-48 in which the Spacer is defined (W) v -S'-P', wherein S' is an C lm . 2 alkyl, an C 2 _ 24 alkenyl, an C 1 _ 24 alkylaryl, an arylC 1 _ 2 alkyl an arylC j ^ 24 alkylaryl, an C 1 _ 2 alkylarylC 1 _ 2 alkyl group which groups may be interrupted by carbonyl, thiocarbony1, oxycarbonyl, carbonyloxy, carbonylamino, aminocarbonyl, aza, oxa or thia groups; an aryl group, an aryloxy, an C 1 _ 2 alkoxy, a polyethyleneglycol group, a SUBSTITUTESHEET steroid group, a sphingoid group; all groups may be substituted with carboxyl. Chalkylcarbonyl, amide, hydroxy, alkoxy, aryloxy, phenoxy; P' is NH-C(S), NH-C(O), C(O), NH, C(S) , C(0)0, (O)CO, SO, S0 2 , 50 3 , S0 4 , P0 3 , P0 4 ; W is NH-C(S), NH-C(O), C(O) , C(S) , C(0)0, (O)CO, SO, S0 2 , S0 3 , 50 4 , P0 2 , P0 3 , P0 4 , with the proviso that when Z λ , Z 2 , Z 4 , Z 7 , Z n or Z 16 are CH 2 then W cannot be P0 2 , with the proviso that when Z , Z 2 , Z 4 , Z 7 , Z 21 or Z 16 are O or S then W cannot be (O)CO, S0 4 or P0 4 , and with the proviso that when Z l t Z 2 , Z 4 , Z 7 , Z n or Z 16 are NH then W cannot be NH-C(S), NH-C(O), (O)CO, S0 4 , P0 4 ; and v is an integer 0 or 1. 50. Novel compounds according to any of claims 49 in which the spacer is selected from spacer1 spacer2 spacer3 spacer4 spacer5 51. Novel compounds according to claims 32-51 in which MA is HSA, BSA or PAA. SUBSTITUTESHEET 52. Novel compounds according to claim 32 in which the compound is selected from [Fucαl-2Gal/3l-Spacer] n -MA; [Fucαl-2Gal/Sl-3GlcNAc/S-Spacer) n -MA; [Fucαl-2Gal/3l-3 (Fucαl-4)GlcNAc/3-Spacer] n -MA; [Fucαl-2Gal/3l-3GlcNAc/3l-3Gal/5l-Spacer) n -MA; [Fucαl-2Gal/Sl-3(Fucαl-4)GlcNAc/3l-3Gal01-Spacer] n -MA; [GalNAcαl-3(Fucαl-2)Gal/Sl-3 (Fucαl-4)GlcNAc01-3Gal/8l-Spacer] n -MA; [Fucαl-2Gal/Sl-3(Fucαl-4)GlcNAc/5l-3Gal/8l-4Glcj8l-NH] n MA; [GalNAcαl-3 (Fucαl-2)Gal/Sl-3 (Fucαl-4)GlcNAq8l-3Gal3l-4Glc/Sl- Spacer] n -MA; wherein the Spacer is selected from the group defined in claim 50, n is an integer 1-40 when MA is HSA or BSA, and n is an interger 10-10000 when MA is PAA. 53. Novel compounds according to claim 32 in which the compound is selected from [Fucαl-2Gal/Sl-Spacer l] n -HSA; [Fucαl-2Gal/3l-Spacer 2] n -PAA; [Fucαl-2Gal/Sl-Spacer 4] n -HSA; [Fucαl-2Gal/Sl-Spacer 5] n -PAA; [Fucαl-2Gal/Sl-3GlcNAc/S-Spacer 5] n -PAA; (Fucαl-2Gal/8l-3 (Fucαl-4)GlcNAc/3-Spacer 5] n -PAA; [Fucαl-2Gal/3l-3 (Fucαl-4)GlcNAcSl-3Gal/Sl-4Glc/3l-NH] n -PAA; wherein Spacer 1, Spacer 2, Spacer 3, Spacer 4 and Spacer 5 are defined as in claim 50 and n is an integer 1-40 when MA is HSA, and n is an interger 10-10000 when MA is PAA. 54. Novel compounds according to any of claims 32-53 wherein the compound of formula la, lb, Ic, Id, Ie or If is adapted to be administered in combination with a preparation for standard therapy of gastritis or ulcus, especially preparations containing omeprazole, cimetidine, ranitidine, lansoprazole, pantoprazole, sucralfate, famotidine, nizetidine, magnesium SUBSTITUTESHEET hydroxide, aluminium hydroxide, calcium carbonate, simethicone or magaldrate. 55. Novel compounds according to any of claims 32-54 wherein the compound of formula la, lb, Ic, Id, Ie or If is adapted to be administered in combination with a preparation for a course of therapy with an antimicrobial agent, especially preparations containing: /3-lactam antibiotics such as amoxicillin, ampicillin, cephalothin, cefaclor or cefixime; or macrolides such as erythromycin, or clarithromycin; or tetracyclines such as tetracycline or doxycycline; or aminoglycosides such as gentamycin, kanamycin or amikacin; o quinolones such as norfloxacin, ciprofloxacin or enoxacin; o others such as metronidazole, nitrofurantoin or chloramphenicol; or preparations containing bismuth salts such as bismuth subcitrate, bismuth subsalicylate, bismuth subcarbonate, bismuth subnitrate or bismuth subgallate. 56. Novel compounds according to any of claims 20-29 for use in therapy. 57. A process for the preparation of novel compounds of the formula la, lb, Ic Id, Ie or If as defined in any of claims 32-53 by methods known in the art. 58. A process according to claim 57 for the preparation of the novel compounds of formula la, lb, Ic, Id, Ie and If, which process comprises i) conversion of a monosaccharide to a glycoside with an aglycon R a to form the R a -glycoside derivative in such a way that the R a - glycoside is possible to transform to a glycosyl donator by activation at the anomeric centre, SUBSTITUTESHEET SUBSTITUTE SHEET

Inventors: EKLIND KARIN INGEBORG, LOENN HANS ROLAND, TIDEN ANNA-KARIN ULLA EDIT, EKLIND, KARIN, INGEBORG, LOENN, HANS, ROLAND, TIDEN, ANNA-KARIN, ULLA, EDIT
Applicants: ASTRA AB, EKLIND KARIN INGEBORG, LOENN HANS ROLAND, TIDEN ANNA KARIN ULLA EDIT, ASTRA AKTIEBOLAG, EKLIND, KARIN, INGEBORG, LOENN, HANS, ROLAND, TIDEN, ANNA-KARIN, ULLA, EDIT
Application year: 1994
Main classification: C07H15
IPC codes: A61K31, A61K33, A61K38, A61K47, A61P1, A61P31, C07H15