Composition and method for protecting keratinous material from keratin digesting insects

Abstract: The present invention provides a composition for protection of keratinous material from keratin digesting insects, and an insect-proofing method using such composition. The composition and method have particular application in treating wool.

Description: The present invention is concerned with an insect-proofing composition and an insect-proofing method. More specifically, the present invention is concerned with an insect-proofing composition comprising N'-alkyl-N'-(3,5-dimethylbenzoyl)-N-(substituted benzoyl)-hydrazine as an active ingredient, and an insect-proofing method using such compound. The composition and method have particular application in treating wool. Several hundred million kilos of wool are treated with mothproofing agents every year. Much of this goes into carpets, apparel, bed wear and upholstery. The key pests are various species of clothing moths. The mothproofing, wool-treating agent(s) can be applied during fibre manufacture, usually during the dyeing process. Several characteristics are desired in a wool-treating agent. For example, the agent must be efficacious against the pests which can damage wool. Typical wool pests which feed on the keratin in wool are Lepidoptera larvae, e.g. Tineola species and Tinea species, and Coleoptera larvae, e.g. Anthrenus species and Attagenus species. The agents used should be stable to hydrolysis, washfast, and lightfast for protecting wool in the processed state. The treated wool has use in woolen textiles such as blankets, wool carpets, woolen underwear, woolen clothing, knits and blends with other natural materials or with artificial fibres. Other beneficial properties of wool-treating agents include low volatility and dry-cleaning fastness. Yet another important property is chemical loading onto the wool, which can be environmentally beneficial by reducing the amount of treatment agent which passes through to waste streams. One measure of loading characteristics is the log P value of the compound, which log P denotes the relative lipophilic value as calculated by C. Hanach et al., in J. Med. Chem. 16, 1207 (1973). Chemical stability during chemical loading is important since the loading may be performed under dyeing conditions (e.g. a pH range to 2 to 7, temperatures of 100°C, dyeing time of one to five hours). Efficacy must be retained after subjection of these harsh conditions as well as in the presence of down-process lubricants, surfactants and other additives. A major wool-treating agent heretofore has been pyrethroids, such as permethrin. Permethrin use, however, has become problematic in its contamination of the aquatic environments which are the recipients of the wool-treatment waste streams. US-A-4,985,461 and US-A-5,117,057 disclose insecticidal N'-substituted-N,N'-diacylhydrazines which are disclosed as having utility against Lepidoptera pests. Journal of Economic Entomology 85 , pages 1099-1103(1992) discloses the use of N'-(3,5-dimethylbenzoyl)-N-(4-ethylbenzoyl)-N'-( tert -butyl)-hydrazine (RH-5992), diluted with water, as an insect growth regulator against the larvae of Corn Earworm and Fall Armyworm. Textilveredlung 24 , pages 389-394 (1989) disloses the use of fenoxycarb to provide preventive, temporary protection against textile pests. New wool-treatment agents which possess the required efficacy to protect wool from pests while having favorable process, environmental and toxicological properties are desired and sought. The present invention provides a composition comprising (i) one or more N'-alkyl-N'-(3,5-dimethylbenzoyl)-N-(substituted benzoyl)-hydrazine, and (ii) one or more treatment bath agent. The amount of the hydrazine(s) in the composition is preferably an effective amount for treating keratinous material, e.g. wool, for protection from keratin digesting insects. The present invention also provides an insect-proofing method using such a composition. The composition and method have particular application in treating wool. More particularly, the compositions of the present invention are compositions comprising (i) one or more N-(2-A-3-B-4-C-benzoyl)-N'-D-N'-(3,5-dimethylbenzoyl)-hydrazine, wherein A, B, and C are independently selected from hydrogen, halogens, (C 1 -C 4 )alkyls optionally substituted with one or more halogen atoms, and (C 1 -C 4 )alkoxys, provided that one or two of A, B or C is hydrogen, and wherein D is a branched (C 4 -C 5 )alkyl, and (ii) one or more treatment bath agent, with the proviso that the composition is not a two-component mixture of N'-(3,5-dimethylbenzoyl)-N-(4-ethylbenzoyl)-N'-( tert -butyl)-hydrazine and water. Preferred halogens are bromo, chloro and fluoro, more preferably chloro and fluoro, and even more preferably chloro. The (C 1 -C 4 )alkyls which can be represented by A, B or C are straight or branched alkyls optionally substituted with one or more halogen atoms; preferably straight, unsubstituted alkyls; more preferably methyl or ethyl. The (C 1 - C 4 )alkoxys are preferably straight alkoxys; more preferably methoxy or ethoxy; even more preferably methoxy. In one embodiment, A, B, and C are independently selected from chloro, methyl and methoxy, provided that one or two of A, B and C is hydrogen. The preferred substituent pattern on the substituted benzoyl is preferably at most only one halogen, alkyl or alkoxy. The D moiety which is the N'-alkyl group is a branched (C 4 -C 5 )alkyl; more preferably neo -pentyl or tert -butyl; even more preferably tert -butyl. The preferred compounds are N'-(3,5-dimethylbenzoyl)-N-(4-ethylbenzoyl)-N'-( tert -butyl)-hydrazine and N-(2,3-dimethylbenzoyl)-N'-(3,5-dimethylbenzoyl)-N'-( tert -butyl)-hydrazine. The treatment bath agent(s) present in the composition of the invention may, for example, be selected from keratinous material treatment carriers (e.g. wool treatment carriers), keratinous material treatment additives (e.g. wool treatment additives), dispersants, cleaning agents, emulsifiers, solvents, surfactants, dyes, levelling agents, antimicrobial agents and finishing agents. The composition of the present invention comprises one or more of the stated hydrazine(s) which preferably has a suitable log P value to permit an effective loading of the hydrazine compound onto the treated fibre. Preferably the log P value ranges from 2 to 6, more preferably from 4 to 6. The compositions of the invention can be used for protecting keratinous material against insects that feed on keratin, e.g. against Lepidoptera larvae such as Tineola spec. and Tiena spec., and also Coleoptera larvae, e.g. Anthrenus spec. and Attagenus spec. The compositions are most suitable for proofing keratinous material against feeding damage by insects, especially for providing such material with a washfast and lightfast protective finish against insects such as moths. The keratinous material to be proofed can be both in the raw and in the processed state, for example raw or processed sheep's wool or products made of other animal hairs, hides, furs and feathers. Preferably, an optimal amount is used in which the desired efficacy is attained while losing a minimal amount of the hydrazine because of a failure of the excess to load onto the keratinous material, e.g. wool. Those skilled in the art can readily determine the amount to be used under the parameters of the particular keratinous material (e.g. wool fibre) and manufacturing (e.g. dyeing) process conditions usable for such material. Processes wherein an insecticidally active compound is loaded onto a fibre are known as the art. For example, see US-A 4,399,280 or the processes described hereinafter. A particularly important feature is the effectiveness of the compositions of the invention against the larvae of the webbing clothes moth (Tineola bisselliella), the common clothes moth (Tinea pellionella) and of the false clothes moth (Hofmannophila pseudopretella). The compositions of the invention are therefore preferably used on the one hand for protecting woolen textiles, for example blankets, wool carpets, woolen underwear, woolen clothing, knits and wool-containing textiles such as blends, one component of which is wool, for example blends of wool and other natural fibres, preferably cotton, or of wool and synthetic fibres, and, on the other hand, also for protecting furs and hides from attack by the above-mentioned pests. The composition may comprise suitable known carriers and/or additives for the treatment of keratinous material, e.g. wool, for protection against keratin digesting insects. Since the treatment of the keratinous material, e.g.wool, can be performed during the keratinous material dyeing process, the carriers and additives should be suitable for use under the conditions of fibre manufacturing, especially the dyeing process. The present invention also provides a process for protecting keratinous material, in particular woolen textiles, from attack by pests that feed on keratin, e.g. moth and moth larvae, which process comprises treating the material to be protected with a composition according to the present invention. To this end, the composition of the invention may additionally contain conventional carriers and formulation assistants, and is normally added to a treatment bath which may additionally contain conventional textile assistants and/or dyes and the material to be protected, which is impregnated within said bath. The bath components may be added to the treatment bath separately. The materials to be protected, in particular textile materials, can be impregnated, such as with hot or cold aqueous dye, in bleaching, chroming or after-treatment baths containing a specific amount of the composition of the invention. Various textile finishing processes are possible, for example the pad or exhaust process. The treatment is conveniently carried out in the temperature range from 10° to 100° C., in the dye bath preferably in the range from about 60° to 100° C., and in the after-treatment or wash bath preferably in the range from 10° to 70° C., most preferably from 20° to 60° C. Further assistants that may be added to the treatment baths include dispersants, emulsifiers or surfactants provided that a maximum amount thereof is not already present in the composition of the invention. The bath liquor can additionally contain further conventional assistants and also antimicrobial agents and finishing agents, for example, those based on synthetic resins or starch. If the insect-proof finishing, e.g. mothproof finishing, is carried out together with the dyeing of the material (e.g. wool), the baths additionally can contain the corresponding dyes and, if appropriate, the necessary assistants, e.g. leveling agents. The aqueous treatment baths may contain, for example, surfactants. If non-aqueous application is made (e.g. solvent application), an appropriate amount of a composition (active ingredient combination) of the invention may also be added to a suitable solvent and the material to be protected may be impregnated with the solution so obtained. The material to be protected is usually simply impregnated with these solutions. The proofing of the material to be protected may also be combined with a dry cleaning process. To this end, an appropriate amount of a composition of the invention is dissolved in the cleaning agent and the cleaning process is carried out in the usual manner. However, an amount of an embodied composition of the invention may also be dissolved in a readily volatile solvent and the resultant solution then sprayed onto the substrate to be protected (spray application). Wool-containing textile fabrics, furs and feathers are particularly suitable for this application. The advantage of the spray application is that pollution of the wastewaters is avoided on account of the recovery of the solvent. In the process of the present invention, the composition of the invention may also be used in combination with other protectants which act against insects that feed on keratin, for example with urea derivatives, benzimidazoles, aromatic sulfonamides and phosphoric and phosphonic acid esters. The amount of a composition of the present invention which is added to the treatment bath or non-aqueous solvent depends on the substrate and the method of application. However, this amount is ordinarily such that, after application to the material which it is desired to protect, the latter contains at least about 1 ppm, for example about 10 to 2000 ppm, and preferably 100 to 1000 ppm, of the hydrazine(s), with the upper limit being largely determined by economic considerations, whereas the lower limit depends on criteria such as the intended breadth and permanency of the protective action. Accordingly, one embodiment of the present invention is a process for treating keratinous material, e.g. wool, comprising the step of treating said keratinous material with a composition according to the invention. Preferably the process treatment is performed in a dye or wash bath in the temperature range from 10° to 100° C. Another embodiment is a process for treating keratinous material, e.g. wool, comprising the step of treating said keratinous material in a cleaning process with a composition according to the invention, and wherein said composition is prepared by dissolving said hydrazine in the cleaning agent.

Claims: A composition for treating keratinous material for protection from keratin digesting insects, which comprises (i) one or more N-(2-A-3-B-4-C-benzoyl)-N'-D-N'-(3,5-dimethylbenzoyl)-hydrazine, wherein A, B and C are substituents independently selected from hydrogen, halogens, (C 1 -C 4 )alkyls optionally substituted with one or more halogen atoms, and (C 1 -C 4 )alkoxys, provided that one or two of A, B, and C is hydrogen, and D is (C 4 -C 5 )alkyl, and (ii) one or more treatment bath agent, with the proviso that the composition is not a two-component mixture of N'-(3,5-dimethylbenzoyl)-N-(4-ethylbenzoyl)-N'-( tert -butyl)-hydrazine and water. A composition as claimed in claim 1, wherein D is neo -pentyl or tertiary butyl. A composition as claimed in claim 1 or claim 2, wherein A, B and C are independently selected from chloro, methyl and methoxy, provided that one or two of A, B, and C is hydrogen, A composition as claimed in claim 1, wherein the hydrazine is selected from N'-(3,5-dimethylbenzoyl)-N-(4-ethylbenzoyl)-N'-( tert -butyl)-hydrazine and N-(2,3-dimethylbenzoyl)-N'-(3,5-dimethylbenzoyl)-N'-( tert -butyl)-hydrazine. A composition as claimed in claim 1, wherein the hydrazine(s) has a log P value from 2 to 6. A process for treating keratinous material, which comprises the step of treating said keratinous material with a composition as claimed in any preceding claim. A process as claimed in claim 6, wherein said treating is performed in a dye or wash bath in the temperature range from 10° to 100° C. A process as claimed in claim 6 or claim 7, wherein the keratin digesting insect is a Lepidoptera larva. A process for treating keratinous material, which comprises the step of treating said keratinous material in a cleaning process, utilizing a cleaning agent, with a composition as claimed in any of claims 1 to 5, and wherein the composition is prepared by dissolving the hydrazine(s) in the cleaning agent. A process as claimed in any of claims 6 to 9, wherein the keratinous material is wool.

Inventors: CARLSON GLENN RICHARD, CARLSON, GLENN RICHARD
Applicants: ROHM & HAAS, ROHM AND HAAS COMPANY
Application year: 1994
Main classification: A01N37
IPC codes: D06M13, D06M16, A01N37, A01N33