TETRACYCLIC COMPOUNDS AS DOPAMINE AGONISTS

Abstract: A tetracyclic compound of formula (I) wherein A and the atoms to which it is attached and the optional double bond represent a mono- or di-heterocyclic ring selected from formulas (a), (b), (c), (d) and (e) wherein R<1>, R<2>, R<3>, R<4> and X are specifically defined, which compounds are useful in the treatment of dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of substance abuse and other addictive behavior disorders, cognitive impairment and attention deficit disorder.

Description: TETRACYCLIC COMPOUNDS AS DOPAMINE AGONISTS Cross Reference to Related Application This application is a continuation-in-part of allowed pending U. S. Patent Application Serial Number 08/043,424, filed April 6, 1993. Technical Field This invention relates to novel tetracydic compounds which are selective dopamine agonists useful for treating dopamine-related neurological, psychological, cardiovascular, cognitive and behavioral disorders. Background of the Invention Dopamine is an important neurotransmitter in the central nervous system (CNS), where it is involved with motor function, perception, arousal, motivation and emotion. Dopamine imbalance is believed to play a key role in a number of CNS-related disorders such as schizophrenia, Parkinson's disease, drug abuse, eating disorders and depression. Dopamine also has several important roles in the peripheral nervous system, such as in the control of blood to the kidneys and in autonomic ganglion transmission. Dopamine receptors in the CNS have traditionally been divided into two general categories, designated D-1 and D-2 receptors, based on biochemical and pharmacological differences between the two receptor types, and recently from the study of the molecular biology of dopamine receptors in the CNS. (For a review of the classification and function of dopamine receptor subtypes, see C. Kaiser and T. Jain, "Dopamine Receptors: Functions, Subtypes and Emerging Concepts", Medicinal Research Reviews, 5:145-229, 1985.) Recent additional evidence has suggested an even greater heterogeneity of the dopamine receptors with three additional dopamine receptors being defined through molecular cloning techniques: the D3 and D4, which are classified as D2-like, and the D5, which exhibits D1 receptor-like pharmacology (D. Sibley and F. Monsma, "Molecular Biology of Dopamine receptors", in TIPS. Vol. 13, pp. 61-69, 1992). Attempts to understand the physiological and pathophysiological roles of the various dopamine receptors are continuing to unveil new avenues for novel therapeutic approaches for the treatment of dopamine-related disorders. A particular dopamine-related problem involves the loss of striatal dopamine within the basal ganglia, the region of the mammalian brain that is 1 SUBSTITUTE SHEET (RULE 25) involved with motor control, which has been established as the fundamental deficit in Parkinson's Disease and primary to the etiology of that disease state. This deficiency is addressed via dopamine replacement therapy, primarily with L- DOPA (3,4-dihydroxyphenylalanine), which is converted to dopamine within the brain. L-DOPA has been the cornerstone of Parkinson's Disease therapy, and the successes achieved with its therapy have led to the testing of other compounds capable of eliciting the post-synaptic receptor actions of dopamine. Bromocriptine, the most widely used direct-acting dopamine agonist for the treatment of Parkinson's Disease, is administered adjunctively with L-DOPA in order to lower dosage of L-DOPA required to achieve the desired therapeutic response. Bromocriptine alone has been shown to relieve Parkinson's Disease symptoms in some patients, allowing for a delay in the onset of L-DOPA therapy, but the response to bromocriptine alone is not as great as that observed with L- DOPA. The current therapies for Parkinson's Disease, including L-DOPA and bromocriptine, are, however, unfortunately associated with a number of serious side-effects and limitations, such as the development of dyskinesias, severe response fluctuations (on-off phenomenon) and diminishing efficacy during treatment. An excess of dopamine in the brain, on the other hand, has been identified, as a result of the pioneering work of Carisson and others in the 1960's, as the cause of schizophrenia, a psychiatric illness involving disturbance of thought processes, hallucinations and loss of touch with reality. Chronic abuse of stimulants, such as amphetamines, known to enhance dopaminergic activity in the brain, can lead to a paranoid psychosis that is clinically indistinguishable from classic paranoid schizophrenia, further supporting this dopamine theory of schizophrenia. Anti-schizophrenic drugs are postulated to exert their effects by blocking the dopamine receptors (i.e., acting as receptor antagonists), and consequently preventing excess receptor stimulation (G.P. Reynolds, "Developments in the drug treatment of schizophrenia", in TIPS, 12:116-121 , 1992). These antipsychotic agents frequently produce undesirable side-effects, however, the most common of which are the extrapyramidal effects that include bizarre involuntary movements and Parkinson-like states, as well as sedation and hypotension. Because of these often-severe side-effects and the high incidence of patients unresponsive to dopamine blocking drugs, novel and improved therapies continue to be sought. One such complement to dopamine receptor antagonists has included the use of low doses of dopamine agonists, such as apomorphine and bromocriptine, which have been reported to produce antipsychotic effects, possibly due to preferential activation of dopamine presynaptic receptors resulting in decreased dopaminergic activity (M. Del Zompo et al, "Dopamine agonists in the treatment of schizophrenia", Progress in Brain Research, £5:41-48, 1986 and H. Y. Meltzer, "Novel Approaches to the Pharmacology of Schizophrenia", Drug Development Research, 2;23 -40, 1936). in addition, the dopamine D1 -selective agonist, SKF 38393, when used in conjunction with the antipsychotic drug, haloperidol, a D2 antagonist, has been shown to ameliorate the undesired side-effects of the haloperidol (M. Davidson, "Effects of the D-1 Agonist SKF-38393 Combined With Haloperidol in Schizophrenic Patients", Arch Gen. Psychiatry, 4Z:190-191 , 1990). Growing evidence (reviewed by R.A. Wise and P.-P. Rompre in "Brain Dopamine and Reward", Annual Review of Psychology, 40:191-225. 1989) suggests that dopamine also has a central role in the brain's reward system. For example, animals trained to self-administer cocaine will increase their consumption of this drug after treatment with either a D-1 or a D-2 receptor antagonist, presumably in order to maintain the elevated dopamine levels responsible for the drug's euphorigenic and reinforcing properties (D.R. Britton et al, "Evidence for Involvement of Both D1 and D2 Receptors in Maintaining Cocaine Self-Administration", Pharmacology Biochemistry & Behavior, 22:911- 915, 1991). The D-1 agonist, SKF 38393, has also been reported to decrease food intake by rats, presumably by direct action of the drug on neural feeding mechanisms. Because of this interrelationship between dopamine and reward, dopaminergic agents would be useful for the treatment of substance abuse and other addictive behavior disorders, including cocaine addiction, nicotine addiction and eating disorders. Affective disorders, the most common psychiatric disorders in adults, which are characterized by changes in mood as the primary clinical manifestation, result from a reduction in the central nervous system of certain biogenic amine neurotransmitters, such as dopamine, noradrenaline and serotonin. Currently- available antidepressants work primarily by raising biogenic amine neurotransmitter levels, by either inhibiting their uptake or preventing their metabolism. No antidepressant drug to date, however, can substitute for electroconvulsive shock therapy for the treatment of severe, suicidal depression. Currently-available drugs for treating affective disorders, unfortunately, suffer from delayed onset of action, poor efficacy, anticholinergic effects at therapeutic doses, cardiotoxicity, convulsions and the possibility of overdosing. A large number of clinically depressed individuals remain refractory to currently-available therapies. A role for direct-acting dopamine agonists in antidepressant therapy has been suggested based on the effects observed for several dopamine agonists in various animal models (R. Muscat et al., "Antidepressant-like effects of dopamine agonists in an animal model of depression", Biological Psychiatry, 21:937-946, 1992). A role for dopamine has also been established in cognition and attention mechanisms. Animal studies support the role of dopamine in attention-related behaviors involving search and exploratory activity, distractibility, response rate, discriminability and the switching of attention. Treatment of cognitive impairment and attention deficit disorders via dopamine-based therapy has been proposed and is under active investigation (F. Levy, "The Dopamine Theory of Attention- Deficit Hyperactivity Disorder (ADHD)", in Australian and New Zealand Journal of Psychiatry, 25:277-283, 1991). In addition, dopamine has been identified with a number of effects in the periphery, and has been used in the treatment of shock, congestive heart failure and acute renal failure. Stimulation of the peripheral D-1 receptors causes vasodilation, particularly in the renal and mesenteric vascular beds where large numbers of these receptors are found. The utility of dopamine has been limited, however, by its ability to cause vasoconstriction at higher concentrations, presumably due to its secondary effects on adrenergic receptors, and by its emetic effects due to peripheral D-2 stimulation. Agents selective for the peripheral D-1 receptors appear to offer significant advantages over currently used treatments for these and other related disorders. Also, dopamine in combination with diuretics has been reported to reverse radio-contrast media-induced acute renal failure in patients (Talley et al., Clin. Res., 12:518, 1970); thus suggesting that dopamine agonists may be similarly useful. A wide variety of structures has been disclosed that are dopamine receptor ligands (H.E. Katerinopoulos and D.I. Schuster, "Structure-Activity Relationships for Dopamine Analogs: A Review", in Drugs Of The Future. Vol. 12, pp. 223-253, 1987) and include the thienopyridines, SKF 86926 (4-(3',4'-dihydroxyphenyl)- 4,5,6,7-tetrahydrothieno(2,3-c)-pyridine) and SKF 86915 (7-(3',4'- dihydroxyphenyl)-4,5,6,7-tetrahydrothieno(3,2-c)-pyridine) (P.H. Andersen era/., European Journal of Pharmacology. 137:291-292. 1987, United States Patents 4,340,600, to L M. Brenner and J.R.Wardell, Jr., issued 1982, and 4,282,227, to LM. Brenner, issued 1981). Nichols et al. have disclosed certain substituted trans-hexahydrobenzo[a]-phenanthridine compounds as dopaminergic ligands (United States Patent 5,047,536, to D. E. Nichols, issued 1991 ; W. K. Brewster_≤f al.. "trans- 0, 11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: A Highly Potent Selective Dopamine D1 Full Agonist", in Journal of Medicinal Chemistry, 22:1756- 1764, 1990). Although various non-hydroxylated compounds having a fused four-ring system have been disclosed (see, for example, Kiguchi et al., Heterocycles, 12:1873-7, 1982; CA 98:16897, describing various intermediates to ergot alkaloids) it is pertinent to emphasize the structural requirements for dopaminergic activity. C. Kaiser and T. Jain, "Dopamine Receptors: Functions, Subtypes and Emerging Concepts", in Medicinal Research Reviews. Vol. 5, pp. 145-229, 1985), have discussed the structural requirements for dopamine activity and emphasized the important effect thereupon of the placement of hydroxyl groups in candidate compounds. D. E. Nichols (U. S. Patent Number 5,047,536, issued September 10, 1991) has disclosed that dihydrexidine, which has the structure: , is active as a dopamine agonist, but Wei and Teitel, (Heterocycles, 2:97, 1979) have disclosed the related compound having the structure: , as being inactive at dopamine receptors. The compound having the structure: , which has a single hydroxyl group on the fused phenyl ring, has been shown (see comparative Example 44, below) to have no agonist properties, but is instead a dopamine antagonist. Applicants have discovered that compounds of the present invention have an unexpectedly narrow range of allowable substituents to the five-membered ring system therein. Comparative Examples 45-47, below, have been prepared that indicate that unlimited substitution on the novel ring system is not permissible in providing for dopamine activity, and that the nature of the substituent groups attached to the five-membered ring system of the present invention significantly alter the properties and functions of the compound (see Table 1 ); compounds of Examples 45-47 having D1 binding constants (Ki) of greater than 2,500 nM, having very low affinity for the dopamine D1 or D2 receptors: (Ex.46), (Ex.47). Summary of the Invention The present invention is directed to dopamine agonists of the formula: or pharmaceutically-acceptable salts, esters or carbamates thereof, wherein: R 1 is hydrogen or a readily-cleavable group; A and the atoms to which it is attached and the dotted-line optional double bond, are selected from : (1 ) an unsaturated mono-heterocyclic ring selected from: , wherein X is sulfur or oxygen; R 2 is hydrogen, Cl, CF3, Ci-Cβ-alkyl, C3-C7-cycloalkyl, -CH2-C3-C5-cycloalkyl, phenyl or thiophene; R 3 is hydrogen, or when R 2 is hydrogen, Cl, Ci-Cβ-alkyl or CF3, R 3 is additionally Cl, Ci-Cs-alkyl or CF3; and R 4 is hydrogen, Cl, Ci-Cβ-alkyl, or C3-C7-cycloalkyl; and (2) an unsaturated di-heterocyclic ring selected from: wherein X and R 2 are as defined above, which bind and activate dopamine receptors in the central and peripheral nervous systems and are useful in the treatment of dopamine-related neurological, psychological and cardiovascular disorders, as well as in the treatment of substance abuse and other addictive behavior disorders, cognitive impairment and attention deficit disorder. Detailed Description of the Invention This invention relates to novel tetracyclic compounds which are selective dopamine agonists of the formula (I): or a pharmaceutically-acceptable salt, ester or carbamate thereof, wherein: R 1 is hydrogen or a readily-cleavable group, as defined below; A and the atoms to which- it is attached are selected from the group consisting of: wherein: X is sulfur or oxygen; R 2 is hydrogen, Cl, CF3, d-Cβ-alkyl, as defined below, C3-C7-cycloalkyl, as defined below,-CH2-C3-C5-cycloalkyl, phenyl or thiophene; R 3 is hydrogen, or when R 2 is hydrogen, Cl, C-|-C6-alkyl or CF3, R 3 is additionally Cl, CrCs-alkyl or CF3; and R 4 is hydrogen, Cl, C-|-C6-alkyl, or C3-C-7-cycloalkyl. Certain compounds of this invention may possess one or more asymmetric centers, including centers in a substituent group, such as an alkyl group, and may exist in optically active forms. Pure d -isomers and pure /-isomers, racemic mixtures of the isomers, and mixtures thereof are intended to be within the scope of this invention. The stereochemistry at the fusion points of the saturated 6- membered rings, as shown in Formula (I), is trans , although the absolute stereochemistry may be [R] or [S] unless specifically noted otherwise. Chiral forms of certain compounds of this invention are contemplated and are specifically included within the scope of this invention. The compounds of formula (I) have the ability to bind and activate dopamine receptors in the central and peripheral nervous systems, thus mimicking the activity of dopamine, and are therefore useful in the treatment of dopamine-related neurological, psychological and cardiovascular disorders, as well as in the treatment of substance abuse and other addictive behavior disorders, cognitive impairment and attention deficit disorder. The present invention also relates to pharmaceutical compositions comprising a therapeutically-effective amount of the compound of formula (I) and a pharmaceutically-acceptable carrier or diluent, and methods of treating dopamine-related disorders. Preferred compounds according to this invention are compounds of formula (I), wherein A and the atoms to which it is attached represent the ring systems: , wherein R 2 is as defined above. More preferred compounds according to this invention are compounds of formula (I), wherein A and the atoms to which it is attached represent a thiophene ring system, in which the arrangements of the double bonds, and the sulfur and carbon atoms is: 3b , wherein R 2 is as defined above. The following are representative of the compounds of Formula (I): frat7s-2-Methyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-4,5,5a,6,7,11 b-Hexahydro-2-thia-5-aza-cyclopenta[c]-phenanthrene-9,10- diol; fraπs-2-Ethyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frans-2-Ethyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; rrat7s-2-(1 ,1 -Dimethylethyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-(2-Propyl)-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Butyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-2-(2-Butyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; fraπs-2-(2,2-Dimethylpropyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza- cyclopenta[c]-phenanthrene-9,10-diol; frans-2-Cyclohexyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; fra/7s-2-Phenyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; trans-2-(1 ,1 -Dimethylethyl)-4,5,5a,6,7,11 b-hexahydro-1-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-2-Ethyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-2-Propyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-2-Butyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-2-Cyclohexyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; ?raπs-4,5,5a,6,7,11 b-Hexahydro-1 -thia-5-aza-cyclopenta[c]-phenanthrene-9,10- diol; frat7S-2-Phenyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frat7s-2-Propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-2,3-Dimethyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-2-Methyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frat7s-2-Methyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-fraπs-2-(1 ,1 -Dimethylethyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza- cyclopenta[c]-phenanthrene-9,10-diol; frat7S-4,5,5a,6,7,11 b-Hexahydro-3-thia-5-aza-cyclopenta[c]-phenanthrene-9,10- diol; frat7S-2-Trifluoromethyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frans-2-Propyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-3,5-diaza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-1 ,5-diaza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-2-Propyl-4,5,5a,6,7,11 b-hexahydro-1 -oxa-3,5-diaza-cyclopenta[c]- phenanthrene-9,10-diol; fraπs-2-(3-Methylbutyl)-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Hexyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Chloro-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-2-(1 -Cyclopentylmethyl)-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza- cyclopenta[c]-phenanthrene-9,10-diol; frans-2-lsopropyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-(3-Methylbutyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Pentyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-2-(2-Thiophenyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; fraπs-2-Hexyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-(Cyclopentylmethyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza- cyclopenta[c]-phenanthrene-9,10-diol; fraπs-2-Ethyl-4,5,5a,6,7,11 b-hexahydro-3-oxa-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; fraπs-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-oxa-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Phenyl-4,5,5a,6,7,11 b-hexahydro-3-oxa-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; fraπs-3-Propyl-4,5,5a,6,7,11 b-hexahydro-2-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; and (-)-frat7s-9,10-Diacetyloxy-2-propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza- cyclopenta[c]phenanthrene; or a pharmaceutically-acceptable salt, ester or carbamate thereof. The following are representative of the more preferred compounds of Formula (I): fraπs-2-Ethyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-fraπs-2-Ethyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-2-Propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-2-(1 ,1 -Dimethylethyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frans-2-Butyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frat7s-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Methyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frat7S-2-Methyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-fraπs-2-(1 ,1-Dimethylethyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza- cyclopenta[c]-phenanthrene-9,10-diol; frat7s-2-Propyl-4,5,5a,6,7,11 b-hexahydro-1 -oxa-3,5-diaza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Ethyl-4,5,5a,6,7,11 b-hexahydro-3-oxa-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; /rat7s-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-oxa-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; and (-)-fraπs-9,10-Diacetyloxy-2-propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza- cyclopenta[c]phenanthrene; or a pharmaceutically-acceptable salt, ester or carbamate thereof. The following are representative of the especially preferred compounds of Formula (I): fraπs-2-Ethyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-fraπs-2-Ethyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frans-2-Propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frans-2-(1 ,1 -Dimethylethyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; fraπs-2-Butyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frat7S-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frans-2-Methyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frat7s-2-Methyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frat?s-2-(1 ,1 -Dimethylethyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza- cyclopenta[c]-phenanthrene-9,10-diol; and (-)-fra/7s-9,10-Diacetyloxy-2-propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza- cyclopenta[c]phenanthrene; or a pharmaceutically-acceptable salt, ester or carbamate thereof. "C1-C5-" or "Ci-Cβ-alkyl" means a straight- or branched-chain hydrocarbon radical containing from one-to-five or from one-to-six carbon atoms, as indicated, including as appropriate, for example, methyl, ethyl, n-propyl, i- prcpyl, n-butyl, sec-butyl, i-butyl, t-butyl, pentyl, hexyl, and the like. "C3-C7-" or "C3-C5-cycloalkyl" means a cyclic hydrocarbon ring containing from three-to-seven carbon atoms or from three-to-five carbon atoms, including, for example, as appropriate, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl. "Readily-cleavable group" as used herein means substituents which are readily cleaved in vivo, for example by hydrolysis in blood or tissue, to yield the compound of Formula (I) wherein R 1 is hydrogen. Readily-cleavable groups include those substituents commonly referred to as "prodrug moieties", see, e.g., T. Higuchi and V. Stella who provide a thorough discussion of the prodrug concept in Pro-drugs as Novel Delivery Systems. Vol. 14 of the A.C.S. Symposium Series, American Chemical Society (1975). Examples of readily- cleavable groups include acetyl, trimethylacetyl, butanoyl, methyl succinoyl, t- butyl succinoyl, ethoxycarbonyl, methoxycarbonyl, benzoyl, 3- aminocyclohexylidenyl, and the like. The term "administration" of the dopaminergic agent or composition, as used herein, refers to systemic use, as when taken orally, parenterally, by inhalation spray, by nasal, rectal or buccal routes, or topically in dosage form unit formulations containing conventional nontoxic pharmaceutically-acceptable carriers, adjuvants and vehicles, as desired. The term "parenteral" as used herein includes intravenous, intramuscular, intraperitoneal, intrasternal, subcutaneous and intraarticular injection and infusion techniques. By "pharmaceutically-acceptable" is meant those salts, esters and carbamates which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response and the like, and are commensurate with a reasonable benefit/risk ratio, effective for their intended use in the treatment of psychological, neurological, cardiovascular and addictive behavior disorders. Pharmaceutically-acceptable salts are well known in the art, as exemplified, for example, by S. M. Berge et al. , who describe pharmaceutically acceptable salts in detail in J. Pharm. Sc , 22: 1-19, 1977. The salts may be prepared in situ during the final isolation and purification of the compounds of Formula (I), or separately by reacting the free base function with a suitable organic acid. Representative acid-addition salts include hydrochloride, hydrobromide, sulfate, bisulfate, acetate, oxalate, valerate, oleate, palmitate, stearate, laurate, borate, benzoate, lactate, phosphate, toluenesulfonate, methanesulfonate, citrate, maleate, fumarate, succinate, tartrate, ascorbate, glucoheptonate, lactobionate, lauryl sulfate salts, and the like. Representative alkali or alkaline earth metal salts include sodium, calcium, potassium, magnesium salts, and the like. Examples of pharmaceutically-acceptable, nontoxic carbamates of the compounds of Formula I include carbamates derived from the phenolic groups (R'NHCO-phenol) or the ring nitrogen atom ring (-N-CO-0-R") wherein R' and R" may be Ci-Cβ-alkyl groups, which may be straight- or branched-chain, or aromatic groups or heterocyclic residues. Carbamates of the compounds of Formula I may be prepared according to conventional methods. As used herein, the term "pharmaceutically-acceptable carriers" means a non-toxic, inert solid, semi-solid or liquid filler, diluent, encapsulating material or formulation auxiliary of any type. Some examples of the materials that can serve as pharmaceutically-acceptable carriers are sugars, such as lactose, glucose and sucrose; starches, such as corn starch and potato starch; cellulose and its derivatives, such as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; powdered tragacanth; malt; gelatin; talc; excipients, such as cocoa butter and suppository waxes; oils, such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; glycols, such as propylene glycol; polyols, such as glycerin, sorbitol, mannitol and polyethylene glycol; esters, such as ethyl oleate and ethyl laurate; agar; buffering agents, such as magnesium hydroxide and aluminum hydroxide; alginic acid; pyrogen- free water; isotonic saline; Ringer's solution; ethyl alcohol and phosphate buffer solutions, as well as other non-toxic compatible substances used in pharmaceutical formulations. Wetting agents, emulsifiers and lubricants, such as sodium lauryl sulfate and magnesium stearate, as well as coloring agents, releasing agents, coating agents, sweetening, flavoring and perfuming agents, preservatives and antioxidants can also be present in the composition, according to the judgment of the formulator. Examples of pharmaceutically-acceptable antioxidants include water-soluble antioxidants, such as ascorbic acid, cysteine hydrochloride, sodium bisulfite, sodium metabisulfite, sodium sulfite, and the like; oil soluble antioxidants, such as ascorbyl palmitate, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), lecithin, propyl gallate, alpha-tocopherol and the like; and the metal chelating agents, such as citric acid, ethylenediamine tetraacetic acid (EDTA), sorbitol, tartaric acid, phosphoric acid and the like. By a "therapeutically-effective amount" of a dopaminergic agent is meant a sufficient amount of the compound to treat dopamine-related disorders at a reasonable benefit/risk ratio applicable to any medical treatment. It will be understood, however, that the total daily usage of the compounds and compositions of the present invention will be decided by the attending physician within the scope of sound medical judgment. The specific therapeutically-effective dose level for any particular patient wϋi depend upon a variety of factors, including the disorder being treated and the severity of the disorder; activity of the specific compound employed; the specific composition employed; the age, body weight, general health, gender and diet of the patient; the time of administration, route of administration, and rate of excretion of the specific compound employed; the duration of the treatment; drugs used in combination or coincidentally with the specific compound employed; and like factors well known in the medical arts. The term "affective disorder" as used herein refers to disorders that are characterized by changes in mood as the primary clinical manifestation, for example, depression. The term "antipsychotic agent" as used herein refers to drugs used extensively in the symptomatic management of all forms of schizophrenia, organic psychosis, the manic phase of manic depressive illness and other acute idiopathic illnesses and occasionally used in depression or in severe anxiety. The term "attention deficit disorder" refers to a recently-classified pediatric neuropsychiatric disorder characterized by inattention, impulsivity, distractibility and sometimes hyperactivity, which replaces the less formal diagnoses of hyperactivity syndrome, hyperkinetic syndrome, minimal brain dysfunction and specific learning disability. The disorder is prevalent among pre-adolescent children and is reflected in poor school performance and social behavior and has been described in experimental reports of impaired perceptual, cognitive and motor function. The term "cognitive impairment" refers to a deficiency in any of the aspects of the cognitive (information processing) functions of perceiving, thinking and remembering. The term "dopamine-related cardiovascular disorders" as used herein refers to conditions which can be reversed or improved by administration of dopamine or a dopaminergic agent, either alone or in combination therapy with other classes of cardiovascular agents. The usefulness of dopaminergic agents in cardiovascular diseases, for example in the treatment of shock and congestive heart failure, is based on the known, but incompletely understood, role of dopamine in the cardiovascular system, especially the effects of dopamine on the heart and the ability of dopamine to produce vasoconstriction while maintaining blood flow through renal and mesenteric beds. Also included are other related, potential uses for dopaminergic agents which include, for example, use in renal failure. The term "dopamine-related neurological and psychological disorders" as used herein refers to behavioral disorders, such as psychoses and addictive behavior disorders; affective disorders, such as major depression; and movement disorders, such as Parkinson's Disease, Huntington's Disease and Gilles de la Tourette's syndrome; which have been linked, pharmacologically and/or clinically, to either insufficient or excessive functional dopaminergic activity in the CNS. Also included are miscellaneous indications for which dopaminergic agents have been found to be clinically useful. Examples of such indications include disorders characterized by vomiting, such as uremia, gastroenteritis, carcinomatosis, radiation sickness, and emesis caused by a variety of drugs; intractable hiccough and alcoholic hallucinosis. "Normal dopamine levels" are those levels of dopamine that are found in the brains of control subjects and are usually measured as levels of the dopamine metabolites homovanillic acid (3-methoxy-4-hydroxyphenylacetic acid) and 3,4-dihydroxyphenylacetic acid. Abnormal dopamine levels are those levels that are not within the range of dopamine levels found in the brains of control subjects. The term "substance abuse" is used herein to mean periodic or regular self-administration of psychoactive substances in the absence of medical indications and despite the presence of persistent or recurrent social, occupational, psychological or physical problems that the person knows are caused by or may be exacerbated by continued use of the substance. The total daily dose of the compounds of this invention administered to a host in single or in divided doses may be in amounts, for example, from 0.01 to 50 mg/kg body weight or more, usually from 0.1 to 30 mg kg body weight. Single dose compositions may contain such amounts or submultiples thereof to make up the daily dose. In general, treatment regimens according to the present invention comprise administration to a patient in need of such treatment from about 10 mg to about 1000 mg of the compound(s) of this invention per day in multiple doses or in a single dose. The compounds of the present invention may be administered alone or in combination or in concurrent therapy with other agents which effect the dopaminergic system, for example, L-dopa, amantadine, apomorphine or bromocryptine; and with cholinergic agents, for example, benztropine, biperiden, ethopromazine, procyclidine, trihexylphenidyl, and the like. The compounds of the present invention may also be co-administered with agents, for example, enzyme inhibitors, which block their metabolic transformation outside the CNS. This invention also provides pharmaceutical compositions in unit dosage forms, comprising a therapeutically-effective amount of a compound (or compounds) of this invention in combination with a conventional pharmaceutical carrier. Injectable preparations, for example, sterile injectable aqueous or oleaginous suspensions, may be formulated according to the known art using suitable dispersing or wetting agents and suspending agents. The sterile injectable preparation may also be a sterile injectable solution, suspension or emulsion in a nontoxic parenterally-acceptable diluent or solvent, for example, as a solution in 1 ,3-butanediol. Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution, U.S. P. and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose, any bland fixed oil may be employed, including synthetic mono- or diglycerides. Also, fatty acids, such as oleic acid, are used in the preparation of injectables. The injectable formulation may be sterilized, for example, by filtration through a bacteria-retaining filter, or by incorporating sterilizing agents in the form of sterile solid compositions which may be dissolved or dispersed in sterile water or other sterile injectable medium just prior to use. In order to prolong the effect of a drug, it is often desirable to slow the absorption of a drug from subcutaneous or intramuscular injection. The most common way to accomplish this is to inject a suspension of the drug in a crystalline or amorphous material which has poor water solubility The rate of absorption of the drug becomes dependent on the rate of dissolution of the drug which is, in turn, dependent on the physical state of the drug, for example, the crystal size of the drug and its crystalline form. Another approach to delaying absorption of a drug is to administer the drug as a solution or suspension in oil. Injectable depot forms may also be made by forming microcapsule matrices of drugs and biodegradable polymers, such as with polylactide-polyglycolide. Depending on the ratio of drug to polymer and the composition of the polymer, the rate of drug release may be controlled by this method. Examples of other biodegradable polymers include poly-orthoesters and polyanhydrides. The depot injectables can also be made by entrapping the drug in liposomes or microemulsions which are compatible with body tissues. Suppositories for rectal administration of the drug may be prepared by mixing the drug with a suitable non irritating excipient, such as cocoa butter and 17 O f ΪD Ti BSTiTUTE SHEET (RULE 26) polyethylene glycol, both of which are solid at ordinary temperature, but liquid at the rectal temperature and will therefore melt in the rectum, releasing the drug. Solid dosage forms for oral administration may include capsules, tablets, pills, powders, prills and granules. In such solid dosage forms the active compound may be admixed with at least one inert diluent, such as sucrose, lactose or starch., such dosage forms may also comprise, as is normal practice, additional substances other than inert diluents, e.g., tableting lubricants and other tableting aids, such as magnesium stearate and microcrystalline cellulose. In the case of capsules, tablets and pills, the dosage forms may also comprise buffering agents. Tablets and pills may additionally be prepared with enteric coatings and other release-controlling coatings. Solid compositions of a similar type may also be employed as fillers in soft and hard-filled gelatin capsules using such excipients as lactose or milk sugar, as well as high molecular weight polyethylene glycols and the like. Liquid dosage forms for oral administration may include pharmaceutically- acceptable emulsions, microemulsions, solutions, suspensions, syrups and elixirs containing inert diluents commonly used in the art, such as water, such compositions may also comprise adjuvants, such as wetting agents; emulsifying and suspending agents; sweetening, flavoring and perfuming agents. If desired, the compounds of the present invention can be incorporated into slow release or targeted-delivery systems, such as polymer matrices, liposomes and microspheres. The active compounds may also be in micro-encapsulated form with one or more excipients as noted above. The solid dosage forms of tablets, dragees, capsules, pills, and granules may be prepared with coatings and shells, such as enteric coatings and other coatings well-known in the pharmaceutical formulating art. They may optionally contain opacifying agents, and may also be of a composition that they release the active ingredient(s) only, or preferably, in a certain part of the intestinal tract, optionally in a delayed manner. Examples of embedding compositions which can be used include polymeric substances and waxes. Dosage forms for topical or transdermal administration of a compound of this invention further include ointments, pastes, creams, lotions, gels, powders, solutions, sprays, inhalants or transdermal patches. The active component is admixed under sterile conditions with a pharmaceutically-acceptable carrier and any needed preservatives or buffers, as required. Ophthalmic formulations, ear drops, eye ointments, powders and solutions are also contemplated as being within the scope of this invention. Administration sublingually, from one or more of the above dosage forms, is also contemplated as a suitable mode of administration of the compounds of the invention. The ointments, pastes, creams and gels may contain, in addition to an active compound of this invention, excipients, such as animal and vegetable fats, oils, waxes, paraffins, starch, tragacanth, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicic acid, talc and zinc oxide, or mixtures thereof. Powders and sprays may contain, in addition to the compounds of this invention, excipients, such as lactose, talc, silicic acid, aluminum hydroxide, calcium silicates and polyamide powder, or mixtures of these substances. Sprays may additionally contain customary propellants, such as chlorofluorohydrocarbons or environmentally- and pharmaceutically-acceptable substitutes. Transdermal patches have the added advantage of providing controlled delivery of a compound to the body. Such dosage forms may be made by dissolving or dispersing the compound in the proper medium. Absorption enhancers may also be used to increase the flux of the compound across the skin. The rate may be controlled by either providing a rate-controlling membrane or by dispersing the compound in a polymer matrix or gel. Synthetic methods In general, the compounds of this invention are synthesized by reaction schemes 1 through 10 as illustrated below. It should be understood that R 2 - R 4 as used herein correspond to the R groups identified by Formula (I). The oxygens of the catechol groups may be derivatized with "protecting groups" (Q), which are known in the art and may be prepared by conventional methods. These derivatizing groups may be selected from among phenol derivatives and derivatives which are suitable to catechols because of the proximity of the two hydroxyl functions. Commonly used phenol derivatives are ethers, for example alkyl, alkenyl, and cycloalkyl ethers (such as methyl, isopropyl, t-butyl, cyclopropylmethyl, cyclohexyl, allyl ethers, and the like); alkoxyalkyl ethers, such as methoxymethyl or methoxyethoxymethyl ether and the like; alkylthioalkyl ethers, such as methylthiomethyl ether; tetrahydropyranyl ethers, arylalkyl ethers (such as benzyl, o-nitrobenzyl, 9-anthrylmethyl, 4-picolyl ethers and the like); trialkylsilyl ethers, such as trimethylsilyl, triethylsilyl, t-butyldimethylsilyl ethers, and the like; alkyl esters, such as acetates, propionates, n-butyrates, isobutyrates, trimethylacetates, benzoates, and the like; substituted alkyl esters, such as 3- (methoxycarbonyl)propionate, 3-aminopropionate, 3-(t- butoxycarbonyl)propionate, and the like; carbonates, such as methyl ethyl, 2,2,2- trichloroethyl, vinyl, benzyl, and the like; carbamates, such as methyl, isobutyl, phenyl, benzyl, dimethyl, and the like; and sulfonates, such as methanesulfonate, trifluoromethanesulfonate, toluenesulfonate, and the like. Commonly used catechol derivatives include cyclic acetals and ketals, such as methylene acetal, acetonide derivatives, cyclohexylidene ketal, diphenylmethylens ketε!, and the like, cyclic esters, such as borate esters, cyclic carbonate esters, and the like. Other hydroxyl-protecting groups (P) may be selected by one skilled in the art as suitable for protecting non-phenol hydroxyl groups. In accordance with Scheme 1 , a diprotected 6,7-dihydroxy-1 -tetralone derivative of formula 1 is reduced with a suitable agent, such as sodium borohydride, lithium aluminum hydride, various other hydride reducing agents, and the like, in a suitable solvent, and the intermediate alcohol thus formed is not isolated, but is dehydrated in the presence of an acid catalyst, such as p- toluenesulfonic acid or the like, to give the protected dihydronaphthalene derivative of formula 2. The compound of formula 2 is reacted with a nitrating agent, such as tetranitromethane, in the presence of a base, such as pyridine in a suitable organic solvent, such as acetone or the like, to give the protected 3- nitro-dihydronaphthalene derivative of formula 3. Scheme 1 1 In accordance with Scheme 2, the compound of formula 5 is prepared by first preparing the anion of an acetal-protected derivative of a 5-substituted-3- carboxaldehyde compound of formula 4, wherein X and R 2 are as defined above, by reacting the compound 4 with a strong base, such as butyllithium, for example, under an inert atmosphere, such as nitrogen or argon, for example, and at a temperature of about 0°C to -78°C for 1 -3 hr. This metallo-organic salt is then condensed with the 3-nitro-dihydronaphthalene derivative of formula 3 in a suitable organic solvent under an inert atmosphere, such as nitrogen or argon, for example, and at a temperature of about 0°C to -78°C for 1-4 hr, followed by quenching of the reaction with aqueous NH4CI followed by equilibration of the reaction product with a catalytic amount of base, such as triethylamine in a solvent, such as acetonitrile to give the trans isomer of compound 5. Compound 20 SUBSTITUTE SHEET (RULE 26 * * 5 is converted to compound 6a by reaction conditions which simultaneously reduce the nitro-group to an amino-group, liberate the aldehyde group from its protecting acetal, and thus promote internal condensation of the amino and aldehyde groups and subsequent reduction by reaction with zinc dust in dilute acid, such as aqueous acetic acid, for example, at a temperature from ambient to about 80°C for 0.1-2 hr. The protecting groups of compound 6a are removed by reacting the compound with a reagent suitable for removal of phenol protecting groups, such as, for example, BBr3 or BCI 3 , in an inert solvent, such as methylene chloride, as is well known in the art, followed by isolation of the 1-thia- or 1-oxa-5-aza-cyclopenta[c]phenanthrene compound of formula 7a. Scheme 2 As alternate means of preparing the compounds of formula 7, in accordance with Scheme 3, a mono- or di-substituted thiophene or furan compound of formula 8, wherein X is O or S and R 2 and R 3 are as defined above, is reacted with a strong base, such as butyllithium, for example, under an inert atmosphere, such as nitrogen or argon, for example, and at a temperature of about ambient to -78°C for 1-4 hr. The metallo-organic derivative of compound 8 is then condensed with the 3-nitro-dihydro-naphthalene derivative of formula 3 under the conditions described for Scheme 2 above, to form the compound 9. Compound 9 is reacted with zinc dust in strong acid, such as 6N HCI, at ambient temperature for 0.5-2 hr, and the amino compound 10 is isolated. In a condensation reaction compound 10 is reacted in the presence of base, such as alcoholic potassium carbonate, with paraformaldehyde at ambient temperature for 8-24 hr, and the solvents removed. The residue is stirred in a strong acid, such as trifluoroacetic acid, for example, for 1-4 hr at ambient temperature, and the product 6 is isolated. Compound 6 is converted into compound 7 by the procedure described for Scheme 2 above. Scheme 3 In accordance with Scheme 4, the N-t-butylamide of the thiophene- or furan-2-carboxylic acid of formula 11 , wherein X is O or S and R 2 is as described above, is reacted with a strong base, such as n-butyllithium, as described in Scheme 2 above and condensed with the 3-nitro-dihydro-naphthalene derivative of formula 3 under the conditions described for Scheme 2 above, to form the compound 12. Compound 12 is reduced with zinc dust in HCI as described above to give the corresponding amino compound 13, which is then heated with acid, such as 10% sulfuric acid or toluenesulfonic acid in refluxing toluene, for example, to give a mixture of compounds 14a and 14b. Compound 14a is then reduced with a suitable reducing agent, such as BH3 or lithium aluminum hydride in a suitable solvent, such as THF or ether, for example, to give the compound 15. Compound 14b is reacted with paraformaldehyde in an organic solvent, such as ethanol or methanol, in the presence of acid, such as 20% HCI, for 1-4 hr at a temperature from ambient to reflux to perform the internal ring closure (Pictet- Spengler cyclization) and give the compound 15. Compound 15 is converted 22 iT> Sϋ o H TE SHEET (RULE 26) into compound 16 by the procedure described for converting compound 6 into compound 7 in Scheme 2 above. Scheme 4 In accordance with Scheme 5, the N,N-diethylamide of thiophene- or furan-3-carboxylic acid of formula 17, wherein X is S or O, is reacted under nitrogen at -78°C with N.N.N'.N'-tetramethyldiaminomethane (TMEDA) and 2- butyl lithium in a suitable solvent, such as cyclohexane, THF or ether, for example, for 1-2 hr, followed by addition of chlorotrimethylsilane with stirring for 1-2 hr, to give the di-substituted thiophene of formula 18. Compound 18 is reacted with a strong base, such as 2-butyllithium in the presence of an additive, such as TMEDA, as described in Scheme 2 above and condensed with the 3- nitro-dihydro-naphthalene derivative of formula 3 under the conditions described for Scheme 2 above, to form the compound 19. Compound 19 is reduced to the corresponding amine as described in previous schemes and cyclized in the presence of a Lewis acid, such as trimethylaluminum, then the trimethylsilyl group is completely removed under acidic conditions to give compound 20. Compound 20 is reduced in a manner similar to the reduction of compound 14a in Scheme 4 above, and deprotected by the procedure described for converting compound 6 into compound 7 in Scheme 2 above. Scheme 5 CONEt, CONEt 2 TMS 17 18 2 steps 21 In accordance with Scheme 6, and as an alternate procedure similar to Scheme 5, wherein the trimethylsilyl compound is prepared, the compound 22, wherein X is S or O, and R 4 is as defined above, is prepared by reacting an appropriate organo-halide compound, such as methyl iodide, ethyl bromide, or the like, or an appropriate chlorinating agent, such as N-chlorosuccinimide, with the anion of compound 17, prepared as described above. It should be understood that the N,N-diethylamide group of compound 17 may be replaced by other substituted amide groups of equal bulk, such as other alkyl groups or cyclic amide groups, as will be readily apparent to those skilled in the art. Compound 22 is then reacted with compound 3 by the method described above, and the compound 23 is reduced to the corresponding amine and cyclized to give compound 24 in the presence of protic or Lewis acids as discussed in Scheme 5, and compound 24 is carried forward to the final compound 25 by a reaction similar to that described in Scheme 4 above. Scheme 6 CONEt 2 .CONEt 2 17 22 2 steps In accordance with Scheme 7, which may be used as an alternate procedure to scheme 6, the compound 26 is reacted with a base such as lithium diisopropyl amide and an appropriate organo-halide compound, such as methyl iodide, propyl iodide or the like, to give compound 27. Compound 27 is then . treated with a metal such as Li or a base such as n-BuLi or t-BuLi to afford the corresponding organolithium species, which is subsequently reacted with formaldehyde (or in a 2-step procedure is reacted first with DMF and then with a reducing agent such as NaBH4), to give a 3-thiophenemethanol compound that may be protected, for example as a methoxymethyl ether or a bulky silyl ether, to give compound 28, where P is the protecting group. Compound 28 is then reacted according to the procedure of scheme 10, first by halogen-metal exchange then by addition to compound 3 to give the compound 29. Compound 29 is reduced with Zn in a strong acid, such as 6N HCI or the like, and the amino compound 30 is isolated. The O-protecting group is then removed by a suitable reagent, such as aqueous HCI, and the free alcohol is converted to a halide, with for example, PBr3, SOCI2, HCI, MsCI/LiCI, or the like, cyclized under basic conditions, for example, with K2CO3 in an alcoholic solution, and the catechol hydroxy groups are deprotected to give compound 31. Alternatively, the amino group of compound 30 may be protected, for example as a t-butyl carbamate, after which the alcohol is deprotected and oxidized to the aldehyde with an appropriate oxidizing agent such as Sθ3 » pyridine or Mnθ2- The amine is then deprotected resulting in condensation of the amino and aldehyde groups to give the corresponding imine which is reduced with an appropriate reagent such as NaCNBH3 in acetic acid. The remaining catechol protecting groups are removed as described in Scheme 2 to give compound 31. Scheme 7 30 31 Scheme 8 \ In accordance with Scheme 8, the substituted oxazole or thiazole compounds of formula 32, wherein X is O or S, the R 5 and R 6 pair are hydrogen and t-butyl, ethyl and ethyl, or hydrogen and methyl, and R 2 is as defined above, are reacted with a strong base, such as butyllithium, as described in Scheme 2 above, and condensed with the 3-nitro-dihydro-naphthalene derivative of formula 3 under the conditions described for Scheme 2 above, to form the compound 33. Compound 33 is reduced with zinc dust in HCI as described above to give the corresponding amino compound 34, which is then cyclized with a protic acid, such as toluenesulfonic acid in toluene, sulfuric acid, or a Lewis acid, such as trimethylaluminum, for example, to give compound 35. Compound 35 is then reduced with a suitable reducing agent, such as BH3 or lithium aluminum hydride in a suitable solvent, such as THF or ether, for example, to give the compound 36. Alternately, it should be understood that the amide compound 34 may be converted to the corresponding alcohol, via hydrolysis to the acid and subsequent reduction with borane, which may be converted to the compound 36 following the procedures described for compound 30 in Scheme 7 above . 27 TUTE SHEET (RULE 26) Compound 36 is converted into compound 37 by the procedure described for converting compound 6 into compound 7 in Scheme 2 above. According to Scheme 9, a suitably-protected or unprotected 2-alkyl-4- thiazolemethanol compound 38 (prepared from L-cysteine ethyl ester as described in Example 27) is reacted with a base such as lithium diisopropyl amide and the intermediate is then added to compound 3 to give the compound 39. Compound 39 is then treated according to the procedures described for compound 29 and sequentially thereafter in Scheme 7 above to give the desired compound 40. Scheme 9 38 via Scheme7 According to Scheme 10, the appropriately protected 2-alkyl-5-bromo-4- oxazolemethanol compound 41 undergoes halogen metal exchange with a metal such as Li or with a strong base, such as n-butyl lithium or t-BuLi, and is then condensed with the compound 3, to give the protected intermediate compound 42. Compound 42 is then treated according to the procedures described for compound 29 and sequentially thereafter in Scheme 7 above to give the desired compound 43. Scheme 10 41 via Scheme 7 The foregoing may be better understood by reference to the following examples which are provided for the illustration and not the limitation of the invention. Example 1 fraπs-2-methvl-4.5.5a.6.7.11 b-hexahvdro-1-thia-5-aza- cvclopenta[c]phenanthrene-9.10-diol Step 1 a. 1.2-Dihydro-6.7-dimethoxynaphthalene To a solution of 5.01 g (24.3 mmol) of 6,7-dimethoxy-1 -tetralone (Aldrich Chemical Co.) in 100 mL of ethanol was added 0.932 g ( 24.6 mmol) of NaBH4, and the mixture was stirred for 14 hr at room temperature. Most of the solvent was removed by evaporation, and to the residue was added 150 mL of methylene chloride and 50 mL of water. The aqueous layer was separated and reextracted with methylene chloride, then the organic extracts were combined and washed with brine, dried over MgSθ4, and concentrated to leave an orange oily residue. The crude intermediate product was dissolved in 100 mL of refluxing toluene, to which was added 48 mg of p-toluenesulfonic acid, and the solution was heated at reflux for 30 min. The reaction was cooled to room temperature and 50 mL of water was added. The aqueous layer was extracted with ethyl acetate, and the organic extracts were combined, washed with brine, dried over MgS04, and concentrated to leave an orange oil. This was dissolved in methylene chloride, which was washed with saturated sodium bicarbonate solution, water, dried and concentrated to afford 4.34 g of the title product (94% yield). NMR (CDCI3) δ: 6.67 (s, 1 H), 6.60 (s, 1H), 6.38 (d, 1 H, J=10 Hz), 5.94(dt, 1 H, J=4 Hz, J=10 Hz), 3.88 (s, 3H), 3.86 (s, 3H), 2.73 (t, 2H, J=8 Hz), 2.32-2.24 (m, 2H). Step 1 b. 1.2-Dihvdro-6.7-dimethoxv-3-nitronaDhthalene To a solution of 9.6 g (50.5 mmol) of 1 ,2-dihydro-6,7- dimethoxynaphthalene, from step 1a above, and 4.90 mL (60.6 mmol) of pyridine in 80 mL of acetone cooled to 0°C was added 10 g (51 mmol) of tetranitromethane (Aldrich Chemical Co.), and the reaction was stirred for 5 min. The reaction was then quenched with 80 mL of 1 M aqueous KOH and stirred at room temperature for 20 min. The yellow precipitate thus formed was filtered off, washed with water and dried. The filtrate was extracted with ethyl acetate, which was acidified with 1 N HCI and washed with water. The solvent was dried over MgS04, concentrated and purified by flash chromatography, eluting with 8:1 hexane.ethyl acetate. The solvent was removed, and the solid was combined with the previous precipitate to afford a total of 9.7 g of the title product as a yellow solid, mp 90.5- 91.0°C NMR (CDCI3) δ: 7.82 (s, 1 H), 6.82 (s, 1 H), 6.75 (s, 1 H), 3.94 (s, 3H), 3.90 (s, 3H), 2.98 (m, 4H). Step 1c. 1 .2-dihvdro-6.7-dimethoxv-4-f5-methvl-2-thiophenvh-3-nitro- naphthaiene A solution of 2-methylthiophene (Aldrich Chemical Co., 0.97 mL, 10 mmol) in 10 mL of dry THF was cooled to -78°C, 4 mL of n-butyl lithium (2.5 M solution in hexanes, 10 mmol) was added, and the solution was stirred at -78°C for 10 min and at 0°C for 2.5 hr. The solution was again cooled to -78°C, and a solution of 2.30 g of 1 ,2-dihydro-6,7-dimethoxy-3-nitronaphthalene (10 mmol, from step 1b above) in THF was added dropwise via a cannula. Stirring was continued as the solution was allowed to warm to room temperature, and the reaction was then quenched with 100 mL of saturated NH4CI solution. The mixture was then extracted with methylene chloride, which was dried over Na2S04 and concentrated in vacuo to afford 3.04 g of crude product. This material was dissolved in 30 mL of acetonitrile and 0.75 mL of triethylamine was added, then the solution was stirred at room temperature for 16 hr. The solution was concentrated in vacuo, and the residue was purified by flash chromatography on silica gel, eluting with 14% ethyl acetate in hexanes, to afford 1.72 g (52% yield) of the trans isomer and 0.65 g (20% yield) of the cis isomer. NMR (CDCI3) (trans isomer) δ: 6.74 (d, 1 H, J=3 Hz), 6.58 (s, 1H), 6.56 (dd, 1 H, J=1 , J=3 Hz), 6.52 (s, 1H), 4.95-4.84 (m, 2H), 3.87 (s, 3H), 3.72 (s, 3H), 3.0-2.85 (m, 2H), 2.5-2.4 (m, 2H), 2.42 (s, 3H). Step 1d. trans-1.2-dihvdro-6.7-dimethoxv-4-(5-methvl-2-thiophenv -3- naphthalene-amine To a suspension of 1.52 g of fraπs-1 ,2-dihydro-6,7-dimethoxy-4-(5-methyl- 2-thiophenyl)-3-nitro-naphthalene (4.5 mmol), from step 1c above, in 40 mL of 95% ethanol and 12 mL of 6N HCI was added 2.97 g of Zn dust (45 mmol), added in four portions. The mixture was stirred at room temperature for 30 min, filtered, and the filtrate concentrated to half the original volume, then extracted with methylene chloride after addition of aqueous sodium bicarbonate solution. The organic extract was dried over Na2SO4 and concentrated to yield 1.35 g of the title product. MS (M+H)+: 304. NMR (CDCI 3 ) δ: 6.70 (d, 1 H, J=3 Hz), 6.60 (bs, 2H), 6.46 (s, 1 H), 3.88 (d, 1 H, J=8 Hz), 3.85 (s, 3H), 3.69 (s, 3H), 3.18 (m, 1 H), 2.92-2.78 (m, 2H), 2.43 (s, 3H), 2.12-2.04 (m, 1 H), 1.78-1.64 (m, 1 H). Step 1e. fraπs-9.10-dimethoxv-2-methvl-4.5.5a.6.7.11 b-hexahvdro-1-thia-5-aza- cyclopenta[c]phenanthrepe To a solution of 1.34 g of trans ,2-dihydro-6,7-dimethoxy-4-(5-methyl-2- thiophenyl)-3-naphthaleneamine (44 mmol), from step 1d above, in 45 mL of methanol was added 2.8 g (20.2 mmol) of K2CO3. The mixture was stirred for 15 min, then 396 mg (13.2 mmol) of paraformaldehyde was added, and the suspension was stirred at room temperature for 18 hours. The reaction was filtered, and the filtrate was concentrated in vacuo. The residue was dissolved in 100 g trifluoroacetic acid (TFA), and the solution was stirred for 3 hr, then concentrated to about 10 mL and adjusted to a basic pH with aqueous sodium bicarbonate solution. The mixture was extracted 2x with methylene chloride, and the extract was washed with brine, then dried over Na2SU4 and concentrated. The residue was purified by flash chromatography, eluting with 4% methanol in methylene chloride to afford 0.35 g (25% yield) of the title product. MS 316 (M+H)+. NMR (CDCI3) δ:7.40 (s, 3H), 6.64 (s, 1 H), 6.48 (s, 1 H), 4.12-4.05 (m, 3H), 3.93 (s, 3H), 3.86 (s, 3H), 3.1-2.88 (m, 3H), 2.47 (s, 3H), 2.28 (m, 1 H), 1.90 (m, 1 H). Step 1f. trat?s-2-methvl-4.5.5a.6.7.11 b-hexahydro-1-thia-5-aza- cvclopenta[c]phenanthrene-9.10-diol hvdrobromide To a stirred solution of 260 mg (0.83 mmol) of 9,10-dimethoxy-2-methyl- 4,5,5a,6,7,11b-hexahydro-1-thia-5-aza-cyclopenta[c]phenanthrene, from step 1e above, in 5 mL of methylene chloride cooled to -78°C was added dropwise 3.3 mL of a 1.M solution of BBr3 in methylene chloride (3.3 mmol). The reaction mixture was allowed to warm to 0°C over a 2 hour period, then stirred at that temperature for 2 hr. The mixture was then cooled to -78°C, and the reaction was quenched by the slow addition of 5 mL of methanol. The solution was then stirred at room temperature for 20 min and at reflux for 30 min, then concentrated in vacuo. The product was collected by triturating with methylene chloride, filtering and drying to afford 274 mg of the title product (90% yield), mp 195-8°C. MS 288 (M+H)+. 1 H NMR (CD 3 OD) δ: 1.9 (m, 1 H), 2.30 (m, 1 H), 2.49 (s, 3H), 2.90 (m, 2H), 3.42 (m, 1 H), 4.28 (d, 1 H, J=11 Hz), 4.35 (s, 2H), 6.62 (s, 1 H), 6.68 (s, 1 H), 7.30 (s, 1 H). Anal. calc. for Ci6Hι 8 BrNO 2 S « 0.3 HBr: C, 48.96; H, 4.70; N, 3.57; found: C. 49.34; H, 4.65; N, 3.49. Example 2 frans-4.5.5a.6.7.11 b-hexahvdro-2-thia-5-aza-cvclopenta.φhenanthrene-9.10- dipl hydrpfrrpmide ^ Step 2a. 3-Thiophenecarboxylic acid. N.N-diethvlamide A solution of 5.0 g (39 mmol) of 3-thiophenecarboxylic acid (Aldrich Chemical Co.), to which was added 10 mL (134 mmol) of SOCI2 in 20 mL of CHCI3 was stirred at reflux for 3 hr. After cooling to room temperature, the solution was concentrated in vacuo. The residue was dissolved in 15 mL of methylene chloride, and the solution was cooled in an ice bath. To this was added dropwise 13 mL (126 mmol) of diethyl amine, and the reaction was stirred at room temperature for 1 hr. Water was added, and the mixture was extracted with methylene chloride, which was washed with aqueous NaHC03 solution, water, and brine, and concentrated to give 9.3 g of crude product. This material was purified by flash chromatography on silica gel, eluting with 6:1 hexane.ethyl acetate, to afford 6.34 g of the title product after removal of the solvents. NMR (CDCI3) δ: 7.48 (dd, 1 H, J=1 , J=3 Hz), 7.32 (dd, 1 H, J=3, J=6 Hz), 7.20 (dd, 1 H, J=1 , J=6 Hz), 3.60-3.30 (bs, 4H), 1.20 (bm, 6H). Step 2b. 2-Trimethylsilvl-3-thiophenecarboxylic acid. N.N-diethvlamide To a solution of 3 g (16.4 mmol) of 3-thiophenecarboxylic acid, N,N- diethylamide, from step 2a above, in 20 mL of THF cooled to -78°C and stirred under N was added 1.68 g (2.1 mL, 16.4 mmol) of N.N.N'.N'- tetramethylenediamine (TMEDA), followed by 12.6 mL of a 1.3 M solution of 2- butyl lithium in cyclohexane (16.4 mmol), and the reaction was stirred for 1 hr. Chlorotrimethylsilane (1.78 g, 2.1 mL, 16.4 mmol) was added, and the solution was stirred for 45 min, then poured into 100 mL of water. The mixture was extracted 3x with methylene chloride, and the solvent was washed with brine, dried over MgS04, concentrated, and purified by flash chromatography, eluting with 3:1 hexane.ethyl acetate to afford 1.4 g (38% yield) of the title product as an oil. MS 256 (M+H)+. NMR (CDCI3) δ: 7.51 (d, 1 H, J=5 Hz), 7.10 (d, 1H, J=5 Hz), 3.60-3.50 (bm, 2H), 3.3-3.10 (bm, 2H), 1.30-1.20 (bm, 3H), 1.15-1.05 (bm, 3H), 0.34 (s, 9H). 2c. trat7s-3-n .2-dihvdro-6.7-dimethoxv-3-nitronaphthalene-4-vl 5-trimethylsilyl- 3-thiophenecarboxylic acid. N.N-diethvlamide To a solution of 1.4 g (5.49 mmol) of 2-trimethylsilyl-3-thiophenecarboxylic acid N,N-diethylamide, from step 2b above, in 15 mL of THF cooled to -78°C was added 0.7 mL (561 mg, 5.49 mmol) of TMEDA, followed by 4.2 mL of a 1.3 M solution of 2-butyl lithium in cyclohexane (5.49 mmol), and the reaction was stirred for 40 min. To this solution was added a solution of 1.30 g of 1 ,2-dihydro- 6,7-dimethoxy-3-nitronaphthalene (5.49 mmol, from step 1b above) in 20 mL of THF, and the reaction was stirred at -78°C for 1 hr and at -20°C for 1.5 hr, then quenched by the addition of saturated NH4CI. The mixture was diluted with water and extracted with methylene chloride. The solvent layer was washed with brine, dried over MgSθ4 and concentrated. The residue was dissolved in 50 mL of acetonitrile, 1 mL of triethylamine was added, and the reaction was stirred for 16 hr. The solvent and amine were removed by evaporation, and the residue was purified by flash chromatography over silica gel to afford 554 mg of the title product. 2d. frat7s-3- 3-amino-1.2-dihvdro-6.7-dimethoxvnaphthalene-4-vh-3- thipphenecarbpxylic acid. N.N-diethylamide To a solution of 554 mg of frat7S-3-(1 ,2-dihydro-6,7-dimethoxy-3- nitronaphthalene-4-yl)-5-trimethylsilyl-3-thiophenecarboxylic acid, N,N- diethylamide, from step 2c above, in 8 mL of ethanol and 3 mL of 6 N HCI was added 700 mg of Zn dust, and the mixture was stirred for 15 min. The mixture was diluted with 20 mL of methylene chloride, then filtered. The organic layer of the filtrate was separated. The aqueous layer was adjusted to pH 10 and extracted with methylene chloride. The extract was dried over Na2SO4, filtered and concentrated. The residue was dissolved in 7 mL of methanol, 3 mL of 6N HCI was added, and the solution was stirred for 4 hr. The methanol was evaporated off, and the residue was dissolved in 6 mL of water, which was then extracted with ether. The aqueous layer was adjusted to pH 10 and extracted with ethyl acetate. Removal of the solvent gave 256 mg of the title product. MS 389 (M+H)+. NMR (CDCI3) δ: 7.24 (d, 1 H, J=6 Hz), 6.93 (d, 1 H, J=6 Hz), 6.58 (s, 1 H), 6.43 (s, 1 H), 4.23 (d, 1 H, J=10 Hz), 3.85 (s, 3H), 3.67 (s, 3H), 3.64 (m, 1 H), 3.50-3.30 (m, 4H), 3.0-2.76 (m, 2H), 2.32-2.22 (m, 1 H), 1.90-1.80 (m, 1 H), 1.26- 1.12 (m, 6H). 2e. fraπs-9.10-dimethoxv-4.5.5a.6.7.11 b-hexahvdro-4-oxo-2-thia-5-aza- cvclopentafφhenanthrene To a solution of 240 mg of frans-3-(3-amino-1 ,2-dihydro-6,7- dimethoxynaphthalene-4-yl)-3-thiophenecarboxylic acid, N.N-diethylamide (from step 2d above) in 10 mL of toluene was added 2 mL of trimethylaluminum, and the solution was heated at reflux for 2 hr. The solution was cooled to room temperature, and the reaction was quenched by addition of Na2SO4 » 10H2O followed by addition of K2CO3 and stirring for 20 min. The mixture was filtered, and the filtrate was evaporated. The residue was dissolved in ethyl acetate, and washed with saturated Na2θθ3 and brine. The solvent was removed, and the material was purified by flash chromatography on silica gel, eluting with 100:5:0.5 methylene chloride:ethanol:ammonium hydroxide, to afford 170 mg of the title product after removal of the solvents. MS 316 (M+H)+. NMR (CDCI3) δ: 7.53 (d, 1 H, J=6 Hz), 7.36 (s, 1 H), 7.17 (d, 1 H, J=6 Hz), 6.65 (s, 1H), 5.75 (bs, 1 H), 4.49 (d, 1 H, J=12 Hz), 3.98 (s, 3H), 3.88 (s, 3H), 3.80 (dd, 1 H, J=4, J=12 Hz), 3.15-2.80 (m, 2H), 2.10-1.95 (m, 2H). 2f. fra/?s-9.10-dimethoxy-4.5.5a.6.7.11 b-hexahvdro-2-thia-5-aza- cvclopentafφhenanthrene To a sample (170 mg) of 9,10-dimethoxy-4,5,5a,6,7,11 b-hexahydro-4-oxo- 2-thia-5-aza-cyclopenta[c]phenanthrene (from step 2e above) was added 10 mL of 1 M BH3 in THF, and the solution was heated at reflux for 8 hr. The reaction was allowed to cool to room temperature, then added to 4 mL of 15% NaOH and saturated NaHCO3. The mixture was extracted with ethyl acetate, which was dried over Na2Sθ4, filtered and concentrated. To the residue was added 1.3 N HCI in methanol, and the solution was heated at reflux for 2 hr. The methanolic HCI was removed by evaporation, and the residue was partitioned between ethyl acetate and 0.5 N NaOH. The ethyl acetate was removed, and the crude material was purified by flash chromatography on silica gel, eluting with 5% methanol in methylene chloride. Removal of the solvent gave 74 mg of the title product (trans isomer). MS 302 (M+H)+. NMR (CDCI3) δ: 7.48 (s, 1 H), 7.20 (d, 1 H, J=6 Hz), 6.84 (d, 1 H, J=6 Hz), 6.67 (s, 1H), 4.14 (s, 2H), 3.98 (d, 1H, J=9 Hz), 3.95 (s, 3H), 3.88 (s, 3H), 3.0-2.8 (m, 3H), 2.22-2.14 (m, 1 H), 1.9-1.78 (m, 1H). 2g. aπs-4.5.5a.6.7.11 b-hexahvdro-2-thia-5-aza-cvclopentarφhenanthrene- 9.10-dipl hydrpbrpmide To a solution of 74 mg (0.24 mmol) of 9,10-dimethoxy-4,5,5a,6,7,11 b- hexahydro-2-thia-5-aza-cyc!openta[c]phenanthrene (from step 2f above) in 2 mL of methylene chloride cooled to -78°C was added 2 mL of BBr3 (1 M in methylene chloride), and the solution was stirred for 1.5 hr, then quenched with 2 mL of methanol. The solution was stirred at 0°C for 30 min, at room temperature for 30 min, and at reflux for 30 min, then concentrated in vacuo and dried to afford 81 mg of a 4/1 trans/cis mixture of the title product. MS 274 (M+H)+. NMR (trans) (CD3OD) δ: 7.38 (d, 1H, J=6 Hz), 6.92 (d, 1H, J=6 Hz), 6.90 (s, 1 H), 6.58 (s, 1 H), 4.45-4.20 (m, 3H), 4.10 (m, 1H), 3.0-2.8 (m, 2H), 2.2-1.95 (m, 2H). Anal Calc. for Ci 5 Hi 6 BrNO2S«0.30 HBr: C, 47.59; H, 4.34; N, 3.70; found: C, 47.87; H, 4.30; N, 3.40. Example 3 frat7s-2-ethyl-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza-cvclopentarc]phenanthrene- 9.10-diol hvdrobromide 3a. 5-Ethvl-2-thiophenecarboxvlic acid To a solution of 20 g (0.18 mol) of 2-ethylthiophene (Aldrich Chemical Co.) in 150 mL of THF cooled to 0°C was added 73 mL (0.18 mol) of 2.5 M (in hexane) n-butyl lithium, and the solution was stirred at 0°C for 40 min, then cooled to -15°C, and gaseous CO2 was bubbled into the mixture. After 40 min, the solution was poured into water and adjusted to pH 14 by addition of 20% NaOH. The solution was washed with ether, which was discarded, and the aqueous layer was adjusted to pH 1 with 6N HCI. This solution was extracted 3x with ethyl acetate, and the extract was dried over MgS04 and concentrated to give 28.3 g (99% yield) of the title product. MS 174 (M+H)+. NMR (CDCI3) δ: 7.73 (d, 1 H, J=3 Hz), 6.84 (d, 1 H, J=3 Hz), 2.90 (q, 2H, J=7 Hz), 1.35 (d, 3H, J=7 Hz). 3b. 5-Ethvl-2-thiophenecarboxvlic acid. N-f-butvl amide To a solution of 28 g (0.18 mol) of 5-ethyl-2-thiophenecarboxylic acid, from step 3a above, in 130 mL of methylene chloride was added a large excess (130 mL, 10 mol) of thionyl chloride, and the solution was heated at reflux for 2 hr. The solvent and excess reagent were removed by evaporation, and the residue was dissolved in 130 mL of chloroform and cooled to 0°C. To this solution was added 94 mL (0.9 mol) of t-butylamine dropwise, and the solution was stirred at reflux for 2 hr. The reaction was cooled, the solution poured into water, and the mixture extracted with ethyl acetate. The extract was washed with water and brine, dried, and concentrated. The residue was dissolved in ethyl acetate and the crude product was precipitated by addition of hexane. The crude product was collected by filtration and purified by flash chromatography over silica gel, eluting with 1 :6 ethyl acetate :hexane, to afford 13.3 g (80% yield) of the title product after drying. MS 212 (M+H)+. NMR (CDCI3) δ: 7.25 (d, 1 H, J=3 Hz), 6.72 (d, 1 H, J=3 Hz), 5.70 (bs, 1 H), 2.84 (q, 2H, J=7 Hz), 1.45 (s, 9H), 1.31 (t, 3H, J=7 Hz). 3c. fraπs-3-n .2-dihvdro-6.7-dimethoxv-3-nitronaphthalene-4-vh-5-ethvl-2- thiophenecarboxylic acid. N-t-butvlamide To a solution of 5.4 g (25.5 mmol) of 5-ethyl-2-thiophenecarboxylic acid, N- f-butyl amide, from step 3b above, in 80 mL of THF cooled to -78°C was added 20.4 mL (51.1 mmol) of n-butyllithium (2.5 M in hexane). The solution was then stirred at 0° for 40 min, then re-cooled to -78°C, and a solution of 6.0 g of 1 ,2- dihydro-6,7-dimethoxy-3-nitronaphthalene, from Example 1 above, in 100 mL of THF cooled to -78°C was added via cannula. The solution was stirred at -78°C for 1 hr and at 0°C for 1 hr. The reaction was quenched with saturated NH4CI, diluted with water, and extracted with methylene chloride. The extract was washed with brine, dried and concentrated. The residue was dissolved in 30 mL of acetonitrile, 1 mL of triethylamine was added, and the reaction was stirred for 16 hr. The solvent was evaporated, and the residue was purified by flash chromatography, eluting with 6:1 hexane:ethyl acetate to afford 5.7 g of the title product. MS 447 (M+H)+, 464 (M+NH 4 )+. NMR (CDCI3) δ: 6.48 (s, 1H), 6.37 (s, 1 H), 6.30 (s, 1 H), 5.70 (bs, 1 H, 5.47 (d, 1 H, J=8 Hz), 5.05 (m, 1 H), 3.85 (s, 3H), 3.69 (s, 3H), 3.2-2.88 (m, 2H), 2.72 (q, 2H, J=7 Hz), 2.5-2.35 (m, 2H), 1.42 (s, 3H), 1.23 (t, 3H, J=7 Hz). 3d. frat7s-3-r3-amino-1.2-dihvdro-6.7-dimethoxvnaphthalene-4-vh-5-ethvl-2- thiophenecarboxvlic acid. N-t-butvlamide To a solution of 5.7 g (127.8 mmol) of 3-(1 ,2-dihydro-6,7-dimethoxy-3- nitronaphthalene-4-yl)-5-ethyl-2-thiophenecarboxylic acid, N-t-butylamide, from step 3c above, in 80 mL of ethanol was added 40 mL of 6N HCI and 8.4 g (127.8 mmol) of Zn dust, and the suspension was stirred for 10 min. The zinc was removed by filtration, and the solution was concentrated by half, diluted with water, and adjusted to pH 9 with 20% NaOH and saturated NaHC03. The mixture was extracted with methylene chloride. The extract was washed with brine, dried over Na2S04, and concentrated to give 5.2 g of the title product. MS 417 (M+H)+. NMR (CDCI3) δ: 6.59 (s. 1 H), 6.28 (s, 1 H), 6.18 (s, 1 H), 4.67 (d, 1H, J=10 Hz), 3.85 (s, 3H), 3.65 (s, 3H), 3.48 (m, 1 H), 3.02-2.80 (m, 2H), 2.72 (q, 2H, J=7 Hz), 2.60 (m, 1 H), 2.10 (m, 1 H), 1.44 (s, 9H), 1.22 (t, 2H, J=7 Hz). 3e. frans-2-ethvl-9.10-dimethoxv-4.5.5a.6.7.11 b-hexahvdro-3-thia-4-oxo-5-aza- cvclopentafφhenanthrene and 4-(5-ethvlthiophene-3-vn-1.2-dihvdro-6.7- dimethoxvnaphthalene-3-amine To a solution of 5.2 g (12.5 mmol) of 3-(3-amino-1 ,2-dihydro-6,7- dimethoxynaphthalene-4-yl)-5-ethyl-2-thiophenecarboxylic acid, N-t-butylamide, from step 3d above, in 6 mL of methanol was added 100 mL of 10% H2SO4. The solution was heated at reflux for 25 hr, and cooled to room temperature. The crude product precipitated out and was collected by filtration, and a second crop was obtained by adjusting the filtrate to pH 9 with 20% NaOH and extracting with methylene chloride. Removal of the solvent and chromatographing provided two products. Total yield of the cyclopentaphenanthrene title product was 1.43 g (33% yield). MS 344 (M+H)+. NMR (CDCI3) δ: 7.15 (s, 2H), 6.66 (s, 1H), 5.73 (bs, 1H), 4.15 (d, 1 H, J=13 Hz), 3.94 (s, 3H), 3.89 (s, 3H), 3.76 (dt, 1 H, J=4, J=13 Hz), 2.90 (q, 2H, J=7 Hz), 2.9-2.8 (m, 2H), 2.05-1.90 (m, 2H), 1.33 (t, 3H, J=7 Hz). The naphthaleneamine product was obtained in 51% yield (2.02 g). MS 318 (M+H)+. NMR (CDCI 3 ) δ: 6.85 (d, 1H, J=1 Hz), 6.60 (s, 1 H), 6.49 (d, 1H, J=1 Hz), 6.33 (s, 1 H), 3.88 (s, 3H), 3.77 (d, 1 H, J=8 Hz), 3.66 (s, 3H), 3.2 (bt, 1 H, J=8 Hz), 2.92-2.82 (m, 2H), 2.79 (q, 2H, J=7 Hz), 2.3-2.0 (bm, 3H), 1.75 (m, 1 H), 1.26 (t, 3H, J=7 Hz). 3f. fraπs-2-ethyl-9.10-dimethoxv-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cyclppentafclphenanthrene To a solution of 2.0 g (6.3 mmol) of 4-(5-ethylthiophene-3-yl)-1 ,2-dihydro- 6,7-dimethoxynaphthalene-3-amine, from step 3e above, in 30 mL of ethanol was added 5 mL of 37% paraformaldehyde, and the reaction was stirred for 15 min. To this solution was added 2 mL of 6 N HCI, and the solution was heated at reflux for 3 hr, then cooled to room temperature. The solution was diluted with water, adjusted to a basic pH with saturated NaHCO3 and extracted with methylene chloride. The organic extract was washed with water and brine, dried over Na2Sθ4, and concentrated. The residue was chromatographed to afford 1.41 g of the title product. MS 330 (M+H)+. NMR (CDCI3) δ: 7.02 (s, 1 H), 6.92 (s, 1 H), 6.74 (s, 1 H), 4.06 (s, 2H), 3.88 (s, 3H), 3.82 (s, 3H), 3.58 (d, 1 H, J=10 Hz), 3.0-2.8 (m, 4H), 2.75-2.65 (m, 1 H), 2.3-2.16 (m, 1 H), 1.75-1.60 (m, 1 H), 1.33 (t, 3H, J=8 Hz). 3α. alternate preparation of frat.s-2-ethvl-9.10-dimethoxv-4.5.5a.6.7.11 b- hexahvdro-3-thia-5-aza-cvclopentarφhenanthrene To a solution of 1.4 g (4.08 mmol) of 2-ethyl-9,10-dimethoxy- 4,5,5a,6,7,11 b-hexahydro-4-oxo-3-thia-5-aza-cyclopenta[c]phenanthrene, from step 3e or 3f above, in 10 mL of THF was added 20.4 mL of BH3/THF (1.0 M in THF). The solution was heated to reflux for 15 hr, cooled to 0°C, and quenched by the addition of 10 mL of 1.3 M HCI in methanol. The solution was then heated at reflux for 4 hr, diluted with water, adjusted to pH 9 and extracted with methylene chloride. The solvent was washed with brine, dried over Na2Sθ4, concentrated, and the residue chromatographed on silica gel, eluting with 2.5:97.5 methanol :methylene chloride. Removal of the solvent afforded 910 mg of the title product (68% yield). 3h. rrans-2-ethyl-4.5.5a.6.7.11b-hexahvdro-3-thia-5-aza- cyclopenta[φhenanthrene-9.10-diol hvdrobromide To a solution of 130 mg (1.03 mmol) of 2-ethyl-9,10-dimethoxy- 4,5,5a,6,7,11b-hexahydro-4-oxo-3-thia-5-aza-cyclopenta[c]phenanthrene, from step 3f above, in 5 mL of methylene chloride cooled to -78°C was added 0.15 mL of BBr3 (1.0 M in CH2CI2), and the solution was stirred at -78°C for 2 hr and 0°C for 2 hr. The solution was then cooled to -78°C, and the reaction was quenched by addition of methanol. The solution was stirred at room temperature for 20 min, heated at reflux for 30 min, and concentrated to a solid residue, which was dried under vacuum to afford 156 mg of the title product . mp 235-236°C. MS 302 (M+H)+. NMR (CD 3 OD) δ: 7.20 (s, 1H), 6.90 (s, 1 H), 6.67 (s, 1 H), 4.46 (s, 2H), 4.02 (d, 1 H, J=11 Hz), 3.2 (m, 1 H), 3.0-2.8 (m, 4H), 2.40-2.28 (m, 1 H), 2.20-1.86 (m, 1 H), 1.36 (t, 3H, J=7 Hz). Anal. calc. for Ci7H2θBrN0 S » 0.10 HBr: C, 52.30; H, 5.19; N, 3.59; found: C, 52.30; H, 5.13; N, 3.54 Example 4 M-fraπs-2-ethvl-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cyclopentafφhenanthrene-9.10-diol hvdrobromide 4a. M-fraπs-2-ethvl-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopenta[c]phenanthrene-9.10-diol A sample of 2-ethyl-9,10-dimethoxy-4,5,5a,6,7,11 b-hexahydro-3-thia-5- aza-cyclopenta[c]phenanthrene, from step 3f or 3g above, was separated by chiral HPLC on a Chiracel™ OD column to give two products. The fraction possessing a specific rotation of [a] (23°C, c=0.68 in methanol) = -321° was isolated and carried forward to the next step. 4b. M-rraπ.ς-2-ethvl-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopentarφhenanthrene-9.10-diol hvdrobromide To a solution of 340 mg (1.03 mmol) of chiral 2-ethyl-9,10-dimethoxy- 4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]phenanthrene, from step a above, in 8 mL of methylene chloride cooled to -78°C was added 8 mL of BBr3 (1 M in methylene chloride), and the solution was stirred at -78°C for 2 hr and 0°C for 2 hr. The solution was then cooled to -78°C, and the reaction was quenched by addition of 4 mL of methanol and stirred for 30 min at room temperature and heated at reflux for 30 min. The volatiles were removed by evaporation, and the residue was dissolved in water and extracted with ether. The aqueous layer was taken to dryness to afford 363 mg (92% yield) of the title product, mp 174-5°C. [α](23°C,c=1.01 in methanol)= -192.2°. MS 302(M+H)+. NMR (CD3OD) δ: 7.20 (s, 1 H), 6.90 (s, 1 H), 6.67 (s, 1 H), 4.46 (s, 2H), 4.02 (d, 1 H, J=11 Hz), 3.2 (m, 1 H), 3.0-2.8 (m, 4H), 2.40-2.28 (m, 1 H), 2.20-1.86 (m, 1 H), 1.36 (t, 3H, J=7 Hz). Calc for C17H2c.BrNO2SO.6O H O: C, 51.94; H, 5.43; N, 3.56; Found: C, 51.74; H, 5.22; N, 3.53. Example 5 fraπs-2-propvl-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopentafφhenanthrene-9.10-diol hvdrobromide 5a. 5-propvl-2-thiophenecarboxvlic acid. N-t-butvl amide To a 5.7 g (46.3 mmol) sample of 2-propylthiophene (prepared according to the method given in Bull. Chem. Soc. Japan, 52, 1865 (1979)) dissolved in 60 mL of THF was added 18.5 mL (46.3 mmol) of a solution of n-butyl lithium (2.5 M in hexane) at 0°C under a nitrogen atmosphere. The solution was stirred at 0°C for 50 min, then cooled to -78°C and 4. 8 g (48.6 mmol) of t-butylisocyanate was added. The solution was stirred at -78°C for 40 min and at 0°C for 1 hr. The reaction was quenched by addition of saturated ammonium chloride solution, then poured into water, and the mixture was extracted with ethyl acetate. The extract was washed with water and brine, dried over MgS04 and concentrated to give 6.27 g of the title product as a solid. MS 226 (M+H)+. NMR (CDCI 3 ) δ: 0.97 (t, 3H, J=8 Hz), 1.45 (s, 9H), 1.7 (sextet, 2H, J=8 Hz), 2.78 (t, 2H, J=8 Hz), 5.7 (bs, 1H), 6.71 (d, 1H, J=4 Hz), 7.25 (d, 1H, J=4 Hz). 5b. 2-propvl-9.10-dimethoxv-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopenta[c]phenanthrene Following the procedures of Example 3c-3f, replacing the 5-ethyl-2- ethylthiophenecarboxylic acid N-t-butyl amide of step 3c with a 6.27g sample of 5-propyi-2-thiophenecarboxylic acid, N-t-butyl amide, from step 5a above, the title compound was prepared. MS 344 (M+H)+. NMR (CDCI3) δ: 1.0 (t, 3H, J=7 Hz), 1.72 (tq, 2H, J=5, J=7 Hz), 1.85-1.95 (m, 1 H), 2.38-2.40 (m, 1 H), 2.81 (t, 2H, J=5 Hz), 2.8-3.05 (m, 3H), 3.68 (d, 1 H, J=10 Hz), 3.81 (s, 3H), 3.88 (s, 3H), 4.12 (s, 2H), 6.73 (s, 1 H), 6.90 (s, 1 H), 7.01 (s, 1 H). 5c. frans-2-propyl-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopentafφhenanthrene-9.10-diol hvdrobromide Reacting the compound from step 5b above with BBrβ (1.0 M in CH2CI2), according to the procedure of Example 3h above, afforded the title compound, mp 133-4°C. MS : 316 (M+H)+. NMR (CD3OD) δ: 1.03 (t, 3H, J=8 Hz), 1.75 (sx, 2H, J=8 Hz), 1.9-2.0 (m, 1 H), 2.28-2.41 (m, 1 H), 2.87 (t, 2H, J=8 Hz), 2.88-3.05 (m, 2H), 3.15-3.27 (m, 1 H), 4.02 (d, 1 H, J=11 Hz), 4.46 (s, 2H), 6.67 (s, 1H), 6.90 (s, 1 H), 7.02 (s, 1 H). Anal. calc. for Ci8H22BrNO 2 S » 0.3H 2 O: C, 53.81 ; H, 5.67; N, 3.49; found: C, 53.67; H, 5.64; N, 3.28. Example 6 fraπs-2-M .1 -dimethylethyl)-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cyclopenta[φhenanthrene-9.10-diol hvdrobromide βa. 5-M .1 -dimethvlethvlV-2-thiophenecarboxvlic acid To a solution of 5.0 g (39.02 mmol) of thiophene-2-carboxylic acid (Aldrich Chemical Co.) in 100 mL of methylene chloride stirred at 0°C was added 11 g (82.5 mmol) of AICI3 and 5.8 g (43.0 mmol) of t-butyl bromide. The solution was stirred at room temperature for 18 hr then poured into 100 mL of ice water, and the mixture was extracted with ether. The extracts were washed with brine and dried over MgSθ4, then concentrated to give 3.33 g of the title product. MS (M+H)+: 202. NMR (CDC! 3 ) δ: 1.42 (s, 9H), 6.89 (d, 1 H, J=4 Hz), 7.72 (d, 1 H, J=4 Hz). 6b. fraπs-2-M .1 -dimethvlethvh-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopenta[c]phenanthrene-9.10-diol hvdrobromide Following the procedures of Example 3b-3f, and 3h, replacing the 2- ethylthiophenecarboxylic acid of step 3b with 5-(1 ,1-dimethylethyl)-2- thiophenecarboxylic acid (from step 6a above) the title compound was prepared. mp 197-8°C. MS : 330 (M+H)+. NMR (CD3OD) δ: 1.46 (s, 9H), 1.86-2.02 (m, 1 H), 2.29-2.43 (m, 1 H), 2.78-3.04 (m, 2H), 3.16-3.28 (m, 1 H), 4.02 (d, 1 H, J=11 Hz), 4.46 (s, 2H), 6.68 (s, 1 H), 6.88 (s, 1 H), 7.03 (s, 1 H). Anal. calc. for Cι 9 H24BrNθ2SO.6H 2 0: C, 54.18; H, 6.03; N, 3.33; found: C, 54.11 ; H, 5.79; N, 3.19. Example 7 fraflg-g-(2-prQpyl)-4.5,5a.6.7,11 b-heχahydrp-3-thia-5-aza- cvclopenta[φhenanthrene-9.10-diol hvdrobromide Following the procedures of Example 6, substituting 2-propyl bromide for the t-butyl bromide of step 6a, the title compound was prepared, mp 186-7°C. MS : 316. NMR (CD 3 OD) δ: 1.39 (d, 6H, J=7 Hz), 1.87-2.02 (m, 1 H), 2.28-2.43 (m, 1 H), 2.8-3.28 (m, 4H), 4.03 (d, 1 H, J=11 Hz), 4.47 (s, 2H), 6.68 (s, 1 H), 6.89 (s, 1 H), 7.03 (s, 1 H). Anal. calc. for Ci8H22BrNO S » 0.4H 2 O: C, 53.57; H, 5.69; N, 3.47; found: C, 53.35; H, 5.48; N, 3.38. Example 8 frat7S-2-butvl-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza-cvclopenta[c]phenanthrene- 9.10-diol hvdrobromide Following the procedures of Example 5, substituting 2-butyl thiophene (prepared according to the method given in Bull. Chem. Soc. Japan, 52, 1865 (1979)) for the 2-propylthiophene of example 5a, the title compound was prepared. mp 152-3°C. MS : 330 (M+H)+. NMR (CD 3 OD) δ: 0.98 (t, 3H, J=7 Hz), 1.35-1.5 (m, 2H), 1.6-1.8 (m, 2H), 1.85-2.0 (m, 1 H), 2.26-2.4 (m, 1H), 2.76-3.05 (m, 4H), 3.16-3.26 (m, 1 H), 4.01 (d, 1 H, J=11 Hz), 4.46 (s, 2H), 6.67 (s, 1H), 6.89 (s, 1 H), 7.02 (s, 1 H). Anal. calc. for Ci 9 H24BrNO 2 S » 0.6H2O: C, 54.18; H, 6.03; N, 3.33; found: C, 54.18; H, 5.83; N, 3.17. Example 9 frans-2-(2-butvl -4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cyclopenta[c]phenanthrene-9.10-diol hvdrobromide Following the procedures of Example 5, substituting 2-(2-butyl)thiophene (prepared according to the method given in Bull. Chem. Soc. Japan, 52, 1865 (1979)) for the 2-propylthiophene of example 5a, the title compound was prepared, mp 164-165°C. MS: 330 (M+H)+. NMR (CD 3 OD) δ: 0.98 (d, 3H, J=7 Hz), 1.01 (d, 3H, J=7 Hz), 1.85-2.0 (m, 2H), 2.27-2.4 (m, 1 H), 2.75 (d, 2H, J=7 Hz), 2.8-3.05 (m, 2H), 3.15-3.28 (m, 1 H), 4.02 (d, 1 H, J=11 Hz), 4.48 (s, 2H), 6.67 (s, 1H), 6.89 (s, 1 H), 7.00 (s, 1 H). Anal. calc. for Ci 9 H 2 4BrNO2S « 0.1HBr: C, 54.53; H, 5.81 ; N, 3.35; found: C, 54.60; H, 5.82; N, 3.28. Example 10 frat7S-2-(2.2-dimethylpropyh-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvcloρentafφhenanthrene-9.10-diol hvdrobromide 10a. 2- ( 2.2-dimethylpropymhiophene To 45 mL of diethylene glycol was added 5.04 g (90 mmol) of KOH, and the mixture was stirred until solution was complete. To this was added 5.05 g (30 mmol) of 2,2-dimethyl-1-thiophenyl-1-propanone (Lancaster Chemical Co.), and 3.75 g of hydrazine monohydrate, and the reaction was stirred at reflux for 48 hr. The solution was cooled, diluted with 100 mL of 1 N HCI and 100 mL of water, and extracted with pentane. The extract was dried over MgSO4, filtered and concentrated to give 4.31 g of the title product. NMR (CDCI3) δ: 0.95 (s, 9H), 2.70 (s, 2H), 6.75 (dd, 1 H, J=1 , J=4 Hz), 6.98 (dd, 1 H, J=4, J=6 Hz), 7.12 (dd, 1 H, J=1 , J=6 Hz). 10b. 2-(2.2-dimethvlpropvh-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopentafφhenanthrene-9.10-diol hvdrobromide Following the procedures of Example 5, substituting 2-(2,2- dimethylpropyl)thiophene, from step 10a above for the 2-propylthiophene of step 5a, the title compound was prepared. MS : 344 (M+H)+. NMR (CD3OD) δ: 1.02 (s, 9H), 1.85-2.0 (m, 1H), 2.28-2.42 (m, 1 H), 2.7-3.05 (m, 4H), 3.15-3.3 (m, 1 H), 4.03 (d, 1 H, J=11 Hz), 4.48 (s, 2H), 6.67 (s, 1 H), 6.89 (s, 1 H), 6.99 (s, 1 H). Anal. calc. for C2θH26BrNO 2 S » 0.1 HBr « 0.1 propanol: C, 56.03; H, 6.90; N, 2.88; found: C, 56.03; H, 6.88; N, 2.84. Example 11 frans-2-cyclohexvl-4.5.5a.β.7.11 b-hexahvdro-3-thia-5-aza- cvclopenta ' φhenanthrene-9.10-diol hvdrobromide 11 a. 2-cvclohexvlthiophene To 20 mL of a 0.5 M solution of tricyclohexylborane (10 mmol, prepared according to Syn. Comm. 12:43 (1982)) was added 10 mL of a 1.0 M solution of 2-lithiothiophene in THF (10 mmol, Aldrich Chemical Co.). The resulting suspension was stirred at reflux for 2 hr, at the end of which the solids had dissolved. The solution was then cooled to -78°C and treated with a solution of iodine (2.54 g 10 mmol) in 15 mL of dry ether, and the reaction was stirred while warming to room temperature over a 2.5 hr period, then stirred for 45 min at room temperature. The reaction was quenched by the careful and simultaneous dropwise addition of 3 N NaOH (10 mL) and 30% H202 (10 mL), then stirred at room temperature for 2 hr. The mixture was diluted with ether, washed with aqueous K2CO3 , water, and brine, and dried, then concentrated in vacuo. The crude product was purified by flash chromatography on silica gel eluting with hexane, to afford after removal of the solvent 1.42 g of the title product. NMR (CDCI3) δ: 1.2-1.5 (m, 6H), 1.6-2.1 (m, 4H), 2.75-2.87 (m, 1 H), 6.80 (dd, 1 H, J=1 , J=3 Hz), 6.92 (dd, 1 H, J=3, J=5 Hz), 7.12 (dd, 1 H, J=1 , J=5 Hz). 11 b. fraπs-2-cvclohexvl-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopentafφhenanthrene-9.10-diol hvdrobromide Following the procedures of example 3a-3f and 3h, substituting the 2- cyclohexylthiophene of step 11a above for the 2-ethylthiophene of example 3a, the title product was prepared. mp 191-2°C. MS : 356 (M+H)+. NMR (CD3OD) δ: 1.2-1.5 (m, 6H), 1.7-2.2 (m, 5H), 2.28-2.4 (m, 1 H), 2.8-3.04 (m, 2H), 3.15-3.3 (m, 1H), 4.02 (d, 1 H, J=11 Hz), 4.46 (s, 2H), 6.67 (s, 1 H), 6.89 (s, 1 H), 7.02 (s, 1 H). Anal. calc. for C21H26BrNO2SO.I H2OO.2HBr: C, 55.51 ; H, 5.86; N, 3.08; found: C, 55.35; H, 5.84; N, 2.98. Example 12 frans-2-phenvl-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopenta[φhenanthrene-9.10-diol hvdrobromide Following the procedures of Example 5, substituting 2-phenylthiophene (prepared according to the method given in Bull. Chem. Soc. Japan, 52, 1865 (1979)) for the 2-propylthiophene of example 5a, the title compound was prepared, mp 204-5°C. MS : 350. NMR (CD3OD) δ: 1.9-2.05 (m, 1 H), 2.32-2.44 (m, 1 H), 2.8-3.06 (m, 2H), 3.2-3.3 (m, 1 H), 4.12 (d, 1 H, J=11 Hz), 4.52 (d, 1 H, J=15 Hz), 4.60 (d, 1 H, J=15 Hz), 6.68 (s, 1 H), 6.97 (s, 1 H), 7.3-7.5 (m, 3H), 7.58 (s, 1 H), 7.66-7.75 (m, 2H). Anal. calc. for C2iH 2 oBrNO S*0.2HBr: C, 56.49; H, 4.56; N, 3.14; found: C, 56.59; H, 4.65; N, 3.12. Example 13 fraπs-2-π .1 -dimethvlethvh-4.5.5a.6.7.11 b-hexahvdro-1-thia-5-aza- cyclopenta[c]phenanthrene-9.10-diol hvdrobromide 13a. 5-M .1-dimethvlethvlϊ-3-thiθDhenecarboxaldehvde To a solution of 3.63 g (32.4 mmol) of 3-thiophenecarboxaldehyde (Aldrich Chemical Co.) in 60 mL of methylene chloride cooled to 0°C was added 9.17 g (80.9 mmol) of AICI3 and 2-methyl-2-bromopropane. The solution was stirred under N2 at room temperature for 16 hr and at reflux for 4 hr. The solution was then cooled to room temperature, and the reaction was quenched by pouring the solution into water. The mixture was made basic with aqueous NaHCθ3 and extracted with ether. The ether extract was washed with water, dried over MgS04 and concentrated. The residue was chromatographed on silica gel, eluting with 15:1 hexane:ethyl acetate, to afford 2.23 g of the title product as an oil, after removal of the solvent. NMR (CD3OD) δ: 1.41 (s, 9H), 7.26 (d, 1 H, J=1 Hz), 8.2 (d, 1 H, J=1 Hz), 9.78 (S, 1 H). 13b. 5-π .1 -dimethvlethvlV3-thiophenecarboxaldehvde ethvleneglvcol acetal To a solution of 2.23 g of 5-(1 ,1-dimethylethyl)-3- thiophenecarboxaldehyde, from step 13a above, in 50 mL of cyclohexane was added 1.65 g (26.5 mmol) of ethylene glycol and 25 mg of p-toluene sulfonic acid. The reaction was heated at reflux for 12 hr, and the water of reaction was collected in a Dean-Stark trap. The reaction was cooled to room temperature, and made basic with the addition of saturated NaHCOβ solution, then extracted with ether. The ether layer was washed with water, dried over MgS04 and concentrated to afford 2.31 g (82% yield) of the title product as an oil. MS 213 (M+H)+. NMR (CDCI3) δ: 1.37 (s, 9H), 4.86 (s, 4H), 5.72 (s, 1 H), 6.87 (d, 1 H, J=1 Hz), 7.23 (d, 1 H, J=1 Hz). 13c. 2-M .2-dihvdro-6.7-dimethoxv-3-nitro-4-naphthvn-5-π .1-dimethvlethvh-3- thiophenecarboxaldehvde ethvleneglvcol acetal To a solution of 1.49 g (7.0 mmol) of 5-(1 ,1-dimethylethyl)-3- thiophenecarboxaldehyde ethyleneglycol acetal, from 13b above, in 10 mL of THF cooled to -78°C and stirred under N2 was added 2.8 mL of n-butyllithium (2.5 M in hexane, 7.0 mmol), and the reaction was stirred at -78°C for 10 min and at 0°C for 50 min. The solution was again cooled to -78°C, and a solution of 1.50 g ( 6.4 mmol) of 1 ,2-dihydro-6,7-dimethoxy-3-nitronaphthalene (from step 1 b above) in 15 mL of THF was added. The solution was stirred at -78°C for 2 hr and at -20°C for 1 hr. The reaction was quenched by the addition of saturated NH 4 CI solution , diluted with methylene chloride and water, and extracted with methylene chloride. The organic extract was washed with water, dried over MgS04 and concentrated. The crude product was dissolved in acetonitrile, treated with a catalytic amount of triethylamine, stirred for 16 hr and concentrated. The residue was chromatographed on silica gel to afford 369 mg (14% yield) of the title product. MS 448 (M+H)+. NMR (CDCI3) δ: 1.30 (s, 9H), 2.4-2.5 (m, 2H), 2.8-3.0 (m, 2H), 3.73 (s, 3H), 3.87 (s, 3H), 3.95-4.05 (s, 2H), 4.1-4.2 (m, 2H), 5.05- 5.1 (m, 1 H), 5.35 (d, 1 H, J=6 Hz), 5.72 (s, 1 H), 6.54 (s, 1 H), 6.57 (s, 1 H), 6.79 (s, 1H). 13d. frat7S-9.10-dimethoxv-2-π .1 -dimethylethvn-4.5.5a.6.7.11 b-hexahvdro-1- thia-5-aza-cyclopentafφhenanthrene To a solution of 390 mg (87 mmol) of 2-(1 ,2-dihydro-6,7-dimethoxy-3-nitro- 4-naphthyl)-5-(1 ,1 -dimethylethyl)-3-thiophenecarboxaldehyde ethyleneglycol acetal, from step 13c above, in 10 mL of a 3:1 mixture of acetic acid:water was added 570 mg of Zn dust, and the suspension was stirred at 60°C for 15 min. The mixture was diluted with methylene chloride and water, made basic by the addition of saturated NaHCθ3 solution, and extracted with methylene chloride. The organic extract was washed with brine, dried over MgS04 and concentrate. The residue was chromatographed on silica gel, eluting with 85:5 methylene chloride:methanol, and the solvent was removed to afford 63 mg (20% yield) of the title product. MS 358 (M+H)+. NMR (CD3OD) δ: 1.39 (s, 9H), 1.78-1.9 (m, 1H), 2.16-2.26 (m, 1 H), 2.85-3.02 (m, 3H), 3.85 (s, 3H), 3.94 (s, 3H), 3.97 (d, 1 H, J=11 Hz), 4.06 (s, 2H), 6.54 (s, 1H), 6.64 (s, 1 H), 7.47 (s, 1H). 13e. fraπs-2-M .1 -dimethvlethvn-4.5.5a.6.7.11 b-hexahvdro-1 -thia-5-aza- cvclopenta[φhenanthrene-9.10-diol hvdrobromide To a solution of 60 mg (0.168 mmol) of 9,10-dimethoxy-2-(1 ,1- dimethylethyl)-4,5,5a,6,7,11 b-hexahydro-1-thia-5-aza- cyclopenta[c]phenanthrene, from step 13d above, cooled to -78° and stirred under N2 was added 168 mg (0.67 mmol) of BBr3 (1.0 M in CH2CI2), and the reaction was stirred for 2 hr and at 0°C for 2 hr. The reaction was again cooled to -78°C, and 2 mL of methanol was added. The solution was stirred at 0°C for 2 hr, then concentrated, and the residue was dried under vacuum at 60°C to afford 67 mg (97% yield) of the title product, mp 202-4°C (dec). MS (M+H)+: 330. NMR (CD3OD) δ: 1.41 (s, 9H), 1.9-2.0 (m, 1 H), 2.26-2.4 (m, 1 H), 2.85-2.95 (m, 2H), 3.35-3.48 (m, 1 H), 4.28 (d, 1 H, J=11 Hz), 4.35 (s, 2H), 6.62 (s, 1 H), 6.76 (s, 1 H), 7.35 (s, 1 H). Anal calc for C19 H24BrNO2S » 0.1 HBr » 0.1 H2O: C, 54.30; H, 5.83;N, 3.33; Found: C, 54.05; H, 5.43; N, 3.17. Example 14 frat.s-2-ethvl-4.5.5a.6.7.11 b-hexahvdro-1 -thia-5-aza-cvclopΘntafφhenanthrena- 9.10-diol hvdrobromide Following the procedure of example 1 , substituting 2-ethylthiophene (Aldrich Chemical Co.) for the 2-methylthiophene of Example 1c, the title compound was prepared, mp 154-5°C. MS : 302. NMR (CD 3 OD) δ: 1.32 (t, 3H, J=7 Hz), 1.88-2.02 (m, 1 H), 2.3-2.4 (m, 1 H), 2.75-3.0 (m, 4H), 3.42 (dt, 1H, J=5, J=11 Hz), 44.29 (d, 1 H, J=11 Hz), 4.37 (s, 2H), 6.63 (s, 1 H), 6.71 (s, 1 H), 7.32 (s, 1 H). Anal. calc. for Ci7H 2 oBrN0 2 S: C, 51.24; H, 5.11 ; N, 3.51 ; found: C, 51.62; H, 5.02; N, 3.45. Example 15 fraπs-2-propvl-4.5.5a.6.7.11 b-hexahvdro-1-thia-5-aza- cyclopenta[c]phenanthrene-9.10-diol hvdrobromide Following the procedure of example 1 , substituting 2-propylthiophene (prepared according to the method given in Bull. Chem. Soc. Japan, 52, 1865 (1979)) for the 2-methylthiophene of Example 1c, the title compound was prepared. mp 183-6°C. MS : 316 (M+H)+. NMR (CD3OD) δ: 1.0 (t, 3H, J=7 Hz), 1.72 (sx, 2H, J=7 Hz), 1.88-2.02 (m, 1 H), 2.26-2.4 (m, 1 H), 2.82 (t, 2H, J=7 Hz), 2.92 (t, 2H, J=6 Hz), 3.36-3.5 (m, 1 H), 4.30 (d, 1 H, J=11 Hz), 4.36 (s, 2H), 6.62 (s, 1 H), 6.71 (s, 1 H), 7.32 (s, 1 H). High Resolution MS analysis: calc: 316.1371 ; found: 316.1384. Example 16 ftans-2-butyl-4.5.5a.6.7.11 b-hexahvdro-1 -thia-5-aza-cvclopentafφhenanthrene- 9.10-diol hvdrobromide Following the procedure of example 1 , substituting 2-butylthiophene (prepared according to the method given in Bull. Chem. Soc. Japan, 52, 1865 (1979)) for the 2-methylthiophene of Example 1c, the title compound was prepared. mp 111-2°C. MS : 330 (M+H)+. NMR (CD3OD) δ: 0.96 (t, 3H, J=7 Hz), 1.35-1.45 (m, 2H), 1.58-1.76 (m, 2H), 1.9-2.0 (m, 1H), 2.05-2.2 (m, 1 H), 2.7-3.0 (m, 4H), 3.41 (dt, 1H, J=6 Hz), 4.28 (d, 1 H, J=11 Hz), 4.38 (s, 2H), 6.62 (s, 1 H), 6.70 (s, 1 H), 7.33 (s, 1 H). Anal. calc. for Ci9H24BrNO2SO.2H O: C, 55.13; H, 5.94; N, 3.38; found: C, 54.97; H, 5.88; N, 3.20. Example 17 frat?s-2-cvclohexvl-4.5.5a.6.7.11 b-hexahvdro-1-thia-5-aza- cyclopenta[φhenanthrene-9.10-diol hvdrobromide Following the procedure of example 1 , substituting 2-cyclohexylthiophene (prepared as described in Example 12 above) for the 2-methylthiophene of Example 1c, the title compound was prepared, mp 195-6°C. MS : 356. High resolution MS Anal. calc. for C21H26 O2S: 356.1693; found: 356.1684. NMR (CD3OD) δ: 1.35-1.50 (m,6H), 1.7-2.1 (m, 5H), 2.26-2.4 (m, 1 H), 2.91 (t, 2H, J=6 Hz), 3.4 (dt, 1 H, J=4, J=11 Hz), 4.38 (d, 1 H, J=11 Hz), 4.46 (s, 2H), 6.61 (s, 1 H), 6.71 (s, 1 H), 7.34 (s, 1H). Example 18 frat7s-4.5.5a.6.7.11b-hexahvdro-1 -thia-5-aza-cvclopentafclphenanthrene-9.10- diol hvdrobromide Following the procedure of Example 13, substituting 3- thiophenecarboxaldehyde for the 5-(1 ,1-dimethylethyl)-3- thiophenecarboxaldehyde of Example 13b, the title compound was prepared. MS : 274 (M+H)+. NMR (CD3OD) δ: 1.9-2.05 (m, 1 H), 2.3-2.4 (m, 1 H), 2.88-2.97 (m, 2H), 3.4-3.5 (m, 1 H), 4.36 (d, 1 H, J=10 Hz), 4.46 (s, 2H), 6.62 (s, 1H), 7.02 (d, 1 H, J-6 Hz), 7.34 (s, 1 H), 7.49 (d, 1 H, J=6 Hz). Anal. calc. for Cι 5 H 16 BrNθ2S*0.2H 2 O: C, 50.34; H, 4.68; N, 3.87; found: C, 50.09; H, 4.77; N, 4.13. Example 19 fra/7g-2-phenyi-4.5.5a,6.7.11b- exahydrp-1-thia-5-aza- cvclopentarφhenanthrene-9.10-diol hvdrobromide 19a. 5-Bromo-3-thiophenecarboxaldehvde To a solution of 6 g (53.45 mmol) of 3-thiophenecarboxaldehyde in 100 mL of methylene chloride cooled to 0°C was added 11.8 g of AICI3, followed by 2.9 mL (56.2 mmol) of Br2. The solution was heated at reflux for 4 hr, the cooled to room temperature, and quenched by pouring into 150 mL of water. The mixture was made basic with satd NaHCθ3 solution and extracted with methylene chloride. The organic extract was washed with water, dried over MgSO4 and concentrated. The residue was chromatographed on silica gel, eluting with 10:1 hexane.ethyl acetate, to afford 9.21 g of the title product as an orange oil. NMR (CDCI 3 ) δ: 7.51 (d, 1 H, J=1 Hz), 8.0 (d, 1 H, J=1 Hz), 9.77 (s, 1 H). 19b. 5-Bromo-3-thiophenecarboxaldehvde ethvlene αlvcol acetal To a solution of 8.5 g of 5-bromo-3-thiophenecarboxaldehyde, from step 19a above, in 150 mL of toluene was added 5 mL of ethylene glycol and 85 mg of p-toluenesulfonic acid. The solution was heated at reflux for 4 hr, and the water of reaction was captured in a Dean-Stark trap. The reaction was cooled to room temperature, diluted with water, made basic with satd NaHC03 solution, and the mixture was extracted with ether. The ether extract was washed with water and brine, and dried over MgSO4. The solvent was removed to afford 10.12 g (96% yield) of the title product as an oil. NMR (CDCI3) δ: 3.98-4.1 (m, 4H), 5.81 (s, 1 H), 7.11 (d, 1 H, J=1 Hz), 7.30 (d, 1 H, J=1 Hz). 19c. 5-Phenyl-3-thiophenecarboxaldehyde ethvlene αlvcol acetal To a suspension of 295 mg (0.26 mmol) of tetrakis(triphenylphosphine palladium (0) (Aldrich Chemical Co.) in ethylene glycol dimethyl ether (DME) was added a solution of 3 g of 5-bromo-3-thiophenecarboxaldehyde ethylene glycol acetal, from step 19b above, in 10 mL of DME. The reaction was stirred for 15 min, and a solution of 2.32 g (19.2 mmol) of phenylboric acid (Aldrich Chemical Co.) in ethanol/Na2C03 was added. The reaction was heated at reflux for 20 hr, then diluted with ether and water and extracted with ether. The extract was washed with water and dried over MgSθ4. Removal of the solvent and chromatography of the residue gave 2.46 g (83% yield) of the title product. NMR (CDCI3) δ: 4.2-4.4 (m, 4H), 5.89 (s, 1 H), 7.2-7.4 (m, 5H), 7.56-7.63 (m, 2H). 21d. traπs-2-phenyl-4.5.5a.6.7.11 b-hexahydro-1-thia-5-aza- cyp|ppenta[p]phenanthrene-9.1 Q-diPl hydrpbrpmide Following the procedures of 13c-13e, substituting 5-phenyl-3- thiophenecarboxyaldehyde ethylene glycol acetal for the 5-(1 ,1-dimethylethyl)-3- thiophenecarboxyaldehyde ethylene glycol acetal of step 13c, the title compound was prepared. mp 236°C. MS (M+H)+ 350. NMR (CD3OD) δ: 1.95-2.05 (m, 1H), 2.3-2.4 (m, 1 H), 2.85-3.0 (m, 2H), 3.49 (dt, 1 H, J=3, J=7 Hz), 4.39 (d, 1 H, J=7 Hz), 4.45 (s, 2H), 6.64 (s, 1 H), 7.29 (s, 1 H), 7.3-7.42 (m, 4H), 7.6-7.7 (m, 2H). Anal calc for C2iH 2 oBrNO 2 S+0.3HBr: C, 55.48; H, 4.50, N, 3.08; Found: C, 55.16; H, 4.28; N, 3.00. Example 20 M-fraπs-2-propvl-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cyp|ppeπta[p]phenaπthreπe-9,10-diPl hydrpbrpmide 47 SUBSTITUTE SHEET (RULE 26 ; Following the procedure of Example 4, substituting the compound from Example 5b for the starting material of Step 4a, the title compound was prepared, mp 155-162°C (dec).MS : 316 (M+H)+. NMR (CD 3 OD) δ: 1.03 (t, 3H, J=8 Hz), 1.75 (sx, 2H, J=8 Hz), 1.9-2.0 (m, 1H), 2.28-2.41 (m, 1H), 2.87 (t, 2H, J=8 Hz), 2.88-3.05 (m, 2H), 3.15-3.27 (m, 1 H), 4.02 (d, 1 H, J=11 Hz), 4.46 (s, 2H), 6.67 (s, 1 H), 6.90 (s, 1 H), 7.02 (s, 1 H). Anal. calc. for Ci8H 2 2BrNO 2 S » 0.7H2θ: C, 52.87; H, 5.77; N, 3.43; found: C, 52.87; H, 5.45; N, 3.34. [α] D = -167° (c=1.03, methanol). Example 21 frans-2.3-dimethvl-4.5.5a.6.7.11 b-hexahvdro-1 -thia-5-aza- cvclopenta[φhenanthrene-9.10-diol hvdrobromide Following the procedures of Example 1 , substituting 2,3-dimethyl thiophene (prepared according to Synthesis, 1Q:545, (1972)) for 2- methylthiophene of step 1c, the title compound was prepared, mp 204-5°C MS 302 (M+H)+. NMR (CD3OD) δ: 7.32 (s, 1 H), 6.61 (s, 1 H), 4.3-4.2 (m, 3H), 3.4 (m, 1 H), 2.95-2.7 (m, 2H), 2.38 (s, 3H), 2.15-1.9 (m, 2H), 2.05 (s, 3H). Anal. calc. for Ci8H2θBrN0 2 S « 0.25 HBr: C, 50.73; H, 5.07; N, 3.48; found: C, 50.74; H, 5.20; N, 3.38. Example 22 fraπs-2-methvl-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopentarφhenanthrene-9.10-diol hvdrobromide Following the procedure of example 3, substituting 5-methyl-2- thiophenecarboxylic acid (Aldrich) for the 5-ethyl-2-thiophenecarboxylic acid of step 3b, the title compound was prepared, mp 223-5 °C. MS 288 (M+H)+. NMR (CD3OD) δ: 7.0 (s, 1 H). 6.89 (s, 1 H), 6.68 (s, 1 H), 4.4 (s, 2H), 4.01 (d, 1 H, J=11 Hz), 3.20 (m, 1 H), 3.02-2.80 (m, 2H), 2.35 (s, 3H), 2.45-2.20 (m, 1 H), 2.0-1.85 (m, 1 H). Anal. calc. for Cι 6 Hi8BrNO S » 0.2HBr: C, 49.99; H, 4.77; N, 3.64: found: C, 50.03, H, 4.81 ; N, 3.59. Example 23 (-Hrar?g-2-methy|-4,5,5a,6,7.11 b-hexahydrp-3-thia-5-aza- cvclopentafφhenanthrene-9.10-diol hvdrobromide This chiral isomer was prepared from the mixture of compounds from Example 22 by the procedure of Example 4. [α]o= -162°, c=1.03 in methanol). mp 201-2°C. Anal. calc. for Ci 6 Hi 8 BrNO2SO.2HBr: C, 49.47; H, 4.73; N, 3.61 ; found: C, 49.45; H, 4.72; N, 3.46. Example 24 M-traπs-2-M .1-dimethvlethv -4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopentafφhenanthrene-9.10-diol hvdrobromide This chiral isomer was prepared from the mixture of compounds from Example 6 by the procedure of Example 4. [α]o= -193° (c=1.04 in methanol). mp 167-8°C. Anal. calc. for Ci9H24BrNO2S » 0.2HBr » 0.2H 2 O: C, 53.05; H, 5.76; N, 3.26; found: C, 53.14; H, 5.67; N, 2.86. Example 25 fraπs-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza-cvclopentarφhenanthrene-9.10- diol hvdrobromide Following the procedure of example 3, substituting 2-thiophenecarboxylic acid (Aldrich) for the 5-ethyl-2-thiophenecarboxylic acid of step 3b, the title compound was prepared, mp. 185°C. MS 274 (M+H)+. NMR (CD 3 OD) δ: 7.59 (d, 1 H, J=3 Hz), 7.32 (d, 1 H, J=3 Hz), 6.88 (s, 1 H), 4.58 (d, 1 H, J=8 Hz), 4.52 (d, 1 H, J=8 Hz), 4.10 (d, 1 H, J=6 Hz), 3.25 (m, 1 H), 2.98 (m, 1 H), 2.84 (m, 1 H), 2.37 (m, 1 H), 1.96 (m, 1 H). Anal. calc. for Ci5Hι 6 BrNO 2 S » 0.2HBr: C, 48.17; H, 4.47; N, 3.74; found: C, 47.92; H, 4.51 ; N, 3.62. Example 26 fraπs-2-trifluoromethvl-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopentafφhenanthrene-9.10-diol hvdrobromide Following the procedure of Example 3, substituting 5-trifluoromethyl-2- thiophenecarboxylic acid (prepared by the method given in J. Fluorine Chem., 45:445 (1990)) for the 5-ethyl-2-thiophenecarboxylic acid in step 3b, the title compound is prepared. Example 27 frat7S-2-Propvl-4.5.5a.6.7.11 b-hexahvdro-1-thia-3.5-diaza- cvclopenta[φhenanthrene-9.10-diol dihvdrobromide 27a. N-Propanovl-L-cvsteine. ethvl ester A suspension of L-cysteine ethyl ester HCI (10 g, 53.9 mmol) in 120 mL of methylene chloride was treated with pyridine (9.2 mL, 113.4 mmol) and stirred at room temperature for 15 min. DMF (20 mL) was added and the mixture was heated to dissolve the solids. The solution was cooled in an ice bath and treated with butyryl chloride (5.7 mL, 53.9 mmol), stirred at 0°C for 1 hr and then at room temperature for 1/2 hr. The reaction solution was poured into water, and the mixture was extracted with ethyl acetate. The organic extract was washed with water and brine, dried over Na2S04, and concentrated to give 11.1 g of an oil. The NMR analysis indicated a 3:1 mixture of the title product and the N,S- dipropionyl analog. The mixture was used without further purification. NMR (CDCI 3 ) for the title compound δ: 6.4-6.3 (bs, 1 H), 4.92-4.85 (m, 1 H), 4.32-4.2 (m, 2H), 3.04 (dd, J=4.5, 9 Hz, 2H), 2.25 (t, J=7 Hz, 2H), 1.7 (q, J=7 Hz, 2H), 1.32 (t, J=7 Hz, 3H), 0.98 (t, J=7 Hz, 3H). 27b. 2-Propanovl-4-thiazolinecarboxvlic acid, ethvl ester The crude mixture from step 27a above was dissolved in 60 mL of methylene chloride and 25 mL of POCI3 (270 mmol) was added, and the reaction was stirred at reflux for 3 hr, cooled to room temperature and the solvent removed under vacuum. The residue was dissolved in 100 mL of THF, cooled to -40°C and treated with NaH (95%, 2.8 g, 101 mmol). The reaction mixture was stirred at 0°C for 2 hr, quenched with aqueous satd. NH4CI, diluted with water and extracted with ether. The extract was washed with water and brine and dried over MgSθ4. The crude product was purified via column chromatography on silica gel, eluting with 6:1 hexane.ethyl acetate, to give 5.9 g (55% yield) of the title product after removal of the solvent. MS: 202(M+H)+. NMR (CDCI3) δ: 5.1- 5.0 (m, 1 H), 4.26 (dq, J=1 , 8 Hz, 2H), 3.6-3.45 (m, 2H), 2.55 (td, J=1 , 9 Hz, 2H), 1.68 (sx, J=9 Hz, 2H), 1.32 (t, J=8 Hz, 3H), 0.98 (t, J=9 Hz, 3H). 27P. 2-Prppyl-4-thiazpleparbPχylip apid. ethyl ester A mixture of the compound from step 27b (7.1 g, 35.3 mmol) and activated Mnθ2 (31 g, 353 mmol) in 80 mL of methylene chloride was stirred at reflux for 6 hr. The suspension was filtered, and the filter cake was washed with methylene chloride and methanol. The filtrates were combined and concentrated under vacuum. The residue was dissolved in 500 mL of ether and washed with water and brine and dried over MgS04. Removal of the solvent gave 5.95 g (85% yield) of the title compound. MS: 200 (M+H)+. NMR (CDCI3) δ: 8.06 (s, 1 H), 4.43 (q, J=8 Hz, 2H), 3.04 (t, J=8 Hz, 2H), 1.9-1.78 (m, 2H), 1.41 (t, J=8 Hz, 3H), 1.03 (t, J=8 Hz, 3H). 27d. 2-Propvl-4-thiazolemethanol A mixture of the compound from step 27c (1.2 g (6 mmol) and NaBH4 (490 mg, 13 mmol) in 15 mL of ethanol was stirred at reflux for 16 hr, then cooled and quenched with water. The mixture was extracted with ether, and the ether extract was washed with water and brine and dried over MgSθ4. The solvent was removed under vacuum to give 0.72 g (76% yield) of the title compound. MS: 156(M+H)+, 173(M+NH 4 )+. NMR (CDCI 3 ) δ: 7.04 (t, J=0.5 Hz, 1 H), 4.74 (dd, J=0.5, 6 Hz, 2H), 2.96 (t, J=8 Hz, 2H), 2.70 (t, J=6 Hz, 1 H), 1.82 (sx, J=8 Hz, 2H), 1.03 (t, J=8 Hz, 3H). 27e. 5-M .2-Dihvdro-6.7-dimethoxv-3-nitro-2-naphthalenvh-2-propvl-4- thiazpiemethanpl A solution of 0.76 g (4.8 mmol) of the compound from step 27d in 15 mL of THF was cooled to -78°C, treated with LDA (Aldrich, 6.8 mL, 1.5 M in hexane, 1.01 mmol), stirred at -78°C for 1 hr, then treated with a precooled (-78°C) solution of 6,7-dimethoxy-2-nitronaphthalene( from Example 1b, 1.2 g, 4.8 mmol) in 15 mL of THF. The resulting milky suspension was diluted with 10 mL of THF , stirred at -78°C for 20 min and at 0°C for 1 hr. The reaction was quenched with aqueous satd. NH4CI, diluted with water, and the mixture extracted with methylene chloride. The extract was washed with water and brine, dried over MgS04 and concentrated. The residue was dissolved in acetonitrile, treated with triethylamine (0.1 mL), stirred for 16 hr at room temperature, and concentrated under vacuum. The crude product was purified by chromatography on silica gel, eluting with 6:1-4:1 hexane.ethyl acetate, to give 470 mg (25% yield) of the title compound. MS: 393(M+H)+. NMR (CDCI3) δ: 6.6 (s, 1 H), 6.41 (s, 1 H), 5.12 (d, J=9 Hz, 1 H), 4.89 (dt, J=6, 9 Hz, 1 H), 4.70 (d, J=6 Hz, 2H), 3.87 (s, 3H), 3.69 (s, 3H), 3.1-2.95 (m, 2H), 2.89 (t, J=8 Hz, 2H), 2.53-2.45 (m, 2H), 2.36 (t, J=6 Hz, 1 H), 1.76 (sx, J=8 Hz, 2H), 0.98 (t, J=8 Hz, 3H). 27f. 5-(3-Amino-1.2-Dihvdro-6.7-dimethoxv-2-naphthalenyn-2-propvl-4- thiazplemethanpl Following the procedure of Example 1d, substituting 0.47 g of the compound from step 27e above for the nitro compound in 1d, a 0.34 g sample of the title compound was obtained. MS: 363 (M+H)+. NMR (CDCI3) δ: 6.58 (s, 1 H), 6.36 (s, 1 H), 4.76 (s, 2H), 4.16 (d, J=9 Hz, 1 H), 3.87 (s, 3H), 3.67 (s, 3H), 3.05-2.80 (m, 5H), 2.2-2.1 (m, 1 H), 1.9-1.7 (m, 3H), 0.99 (t, J=8 Hz, 3H). 27α. trans-9Λ 0-Dimethoxv-2-propvl-4.5.5a.6.7.11 b-hexahvdro-1 -thia-3.5-diaza- cvclopentafφhenanthrene A -78°C solution of the compound from step 27f (0.33 g, 0.9 mmol) in 12 mL of methylene chloride was treated with PBr3 (0.3 mL, 2.7 mmol). The cooling bath was removed, and the reaction was stirred at room temperature for 16 hr, 51 SU3G7.TUTΞ SHEET (RULE 26) then quenched with 20% aqueous NaOH. The mixture was stirred at room temperature for 20 min, poured into water and extracted with methylene chloride. The extract was concentrated, and the residue was purified by chromatography on silica gel, eluting with 5% methanol in methylene chloride. Removal of the solvent and drying afforded 75 mg (24% yield) of the title compound. MS: 345 (M+H)+. NMR (CDCI 3 ) δ: 7.2 (s, 1 H), 6.66 (s, 1 H), 4.24 (s, 2H), 4.05 (d, J=10 Hz, 1 H), 3.94 (s, 3H), 3.88 (s, 3H), 3.1-2.85 (m, 5H), 2.3-2.2 (m, 1 H), 2.0-1.86 (m, 1 H), 1.83 (sx, J=8 Hz, 2H), 1.03 (t, J=8 Hz, 3H). 27h. fraπs-2-Propvl-4.5.5a.6.7.11 b-hexahvdro-1 -thia-3.5-diaza- cvclopenta[φhenanthrene-9.10-diol dihvdrobromide Following the procedure of Example 1f, a 75 mg sample of the compound from step 27g above was converted to the title compound (85 mg, 80% yield), mp. 172-174°C. MS: 317 (M+H)+. NMR (CD3OD) δ: 7.12 (s, 1 H), 6.62 (s, 1 H), 4.54 (m, 1 H), 4.45 (d, J=12 Hz, 1 H), 3.59 (ddd, J=5, 12, 12 Hz, 1 H), 3.07 (t, J=8 Hz, 2H), 3.05-2.9 (m, 2H), 2.44-2.33 (m, 1 H), 2.1-1.95 (m, 1 H), 1.87 (sx, J=8 Hz, 2H), 1.05 (t, J=8 Hz, 3H). Anal. Calcd for Ci7H 2 2Br2N2θ 2 S: C, 42.69; H, 4.64; N, 5.86; Found: C, 42.56; H, 4.30; N, 5.75. Example 28 frat7g-2-prQpyl-4,5,5a,6,7,ι 1 b-heχahydrp-3-thia-1 ,5-diaza- cvclopenta[φhenanthrene-9.10-diol hvdrobromide 28a. 2-propvl-3-thiazolecarboxvlic acid. N-t-butvl amide Following the procedure of Example 5, substituting 2-propylthiazole (Oxford Chemicals) for the 2-propylthiophene in step 5a, the title compound is prepared. 28b. fraπs-2-propvl-4.5.5a.6.7.11 b-hexahvdro-3-thia-1.5-diaza- cvclopenta[φhenanthrene-9.10-diol hvdrobromide Following the procedures of Example 3c-3h, replacing the 5-ethyl-2- thiophenecarboxylic acid in step 3c with the 2-propyl-3-thiazolecarboxylic acid, N-t- butyl amide, from step 28a above, the title compound is prepared. Example 29 frar.g-2-Prppyl-4,5.5a,6,7.11 b-hexahydrp-1 -pχa-3.5-diaza- cvclopentafφhenanthrene-9.10-diol hvdrobromide 29a. 5-Bromo2-Dropvl-4-oxazolecarboxvlic acid methvl ester The title compound was prepared according to the procedure of Das et al., Tetrahedron Lett., 22:7835, 1992. MS: 248 (M+H)+, 250 (M+H)+, 265 (M+NH 4 )+, 267 (M+NH 4 )+. NMR (CDCI 3 ) δ: 3.53 (s, 3H), 2.78 (t, J=8 Hz, 2H), 1.82 (sx, J=8 Hz, 2H), 1.00 (t, J=8 Hz, 3H). 29b. 5-Bromo-2-propyl-4-oxazolemethanol A 4.245 g (17.12 mmol) sample of the compound from step 29a above was dissolved in 80 mL of methylene chloride and cooled to 0°C. DIBAL-H (1.0 M in hexane, 37.0 mmol) was added via syringe. The resulting solution was stirred for 15 min. Methanol (2 mL) was added slowly, followed by 80 mL of satd. potassium sodium tartrate, and the mixture was stirred for 1 hr. The organic layer was separated , and the aqueous layer was extracted with 2 x 50 mL of methylene chloride. The organics were combined, dried over MgSO4 and concentrated. The residue was purified by column chromatography on silica gel, eluting with 20-60% ethyl acetate in hexane, to afford 3.490 g (93% yield) of the title product. MS: 220(M+H) + , 222(M+H)+, 237(M+NH 4 ) + , 239 (M+NH 4 ) + . NMR (CDCI3) δ: 4.50 (s, 2H), 2.72 (t, J=8 Hz, 2H), 2.0 (br s, 1 H), 1.79 (sx, J=8 Hz, 2H), 1.00 (t, J=8 Hz, 3H). 29c. 5-Bromo-2-propvl-4-((f2-tetrahvdroDvranvnoxv^methvnoxazole To a solution of 1.96 g (8.91 mmol) of the compound from step 29b in 55 mL of methylene chloride at room temperature were sequentially added 7 mL of 3,4-dihydro-2H-pyran (76.7 mmol) and 1 g (3.98 mmol) of PPTS. The reaction was stirred at room temperature for 20 min, 30 mL of satd. NaHCOβ was added, and the mixture was stirred for 5 min. The organic layer was separated , and the aqueous layer was extracted with 2 x 50 mL of methylene chloride. The organics were combined, dried over MgS04 and concentrated. The residue was purified by flash chromatography on silica gel, eluting with 10-30% ethyl acetate in hexane, to afford, after removal of the solvent and drying, 2.70 g (100% yield) of the title product as a colorless oil. NMR (CDCI3) δ: 4.75 (t, J=3 Hz, 1 H), 4.57 and 4.33 (ABq, J=12 Hz, 2H), 3.93 (m, 1 H), 3.56 (m, 1 H), 2.72 (t, J=8 Hz, 2H), 1.90- 1.48 (m, 8H), 1.00 (t, J=8 Hz, 3H). 29d. 5- .7-Dihvdro-2-nitro-1.2.3.4-tetrahvdro-2-naphthalenyh-2-propvl-4-r^2- tetrahvdropyranvhoxv^methvhoxazole n-Butyllithium (2.5 M in hexane, 10 mmol) was added to a solution of the compound from step 29c (2.70 g, 8.88 mmol) in 40 mL of THF cooled to -78°C. The resulting yellow solution was stirred for 30 min at -78°C, and a solution of 6,7-dimethoxy-3,4-dihydroxy-2-nitronaphthalene (2.227 g, 9.48 mmol), from Example 1b, precooled to -78°C, was added via cannula. The reaction was stirred for 2 hr at -78°C, then the reaction was quenched by the addition of 10 mL of satd. NH4CI. After warming to room temperature, the organic layer was separated , and the aqueous layer was extracted with 2 x 50 mL of methylene chloride. The organics were combined, dried over MgSO4 and concentrated. The crude product was dissolved in 45 mL of methanol and treated with 8 mL of triethylamine. This solution was stirred for 15 hr at room temperature. The solvent was removed under reduced pressure, and the residue was chromatographed on silica gel, eluting with 30-60% ethyl acetate in hexane, to afford after removal of the solvent and drying, 3.64 g (89% yield) of the title product as an oil. MS: 461 (M+H) + . NMR showed a mixture of diastereomers. 29e. frans-5-f2-Amino-6.7-dimethoxv-1.2.3.4-tetrahvdro-2-naDhthalenvh-2- prppyl-4-pχazplemethanpl To a solution of the compound from step 29d (1.16 g, 2.52 mmol) in 40 mL of ethanol was added 10 mL of 6 N HCI. The mixture was stirred for 30 min at room temperature, and zinc dust was added in portions until the yellow solution turned colorless. Satd. NaHCO3 solution was added until the mixture was at pH 8-9. The solid was removed by filtration and washed with methylene chloride. The filtrate and washings were combined, dried over MgSθ4 , concentrated, and purified by chromatography on silica gel, eluting with 5-40% methanol (containing 5%NH4θH) in methylene chloride, to afford 742 mg (85% yield) of the title product as a 1 :6.5 mixture of cis:trans isomers. Recrystallization from 1 :1 hexane:ethyl acetate provided the pure trans isomer as a solid. MS: 347(M+H) + . NMR (CDCI3) δ: 6.62 (s, 1 H), 6.29 (s, 1H), 4.62 and 4.52 (abq, J=13 Hz, 2H), 4.02 (d, J=10 Hz, 1 H), 3.87 (s, 3H), 3.68 (s, 3H), 3.17 (m, 1 H), 3.03-2.79 (m, 2H), 2.65 (t, J=8 Hz, 2H), 2.18 (m, 1 H), 1.81 (m, 1 H), 1.72 (sx, J=8 Hz, 2H), 0.92 (t, J=8 Hz, 3H). 29f. trans-9Λ 0-Dimethoxy-2-propyl-4.5.5a.6.7.11 b-hexahvdro-1-oxa-3.5-diaza- pyplppenta[p]phenanthrene PBr3 (0.9 mL) was added to a solution of the compound from step 29e above (320 mg, 0.92 mmol) in 25 mL of methylene chloride cooled to -78°C, and the mixture was stirred for 15 min. The cooling bath was removed, and the reaction was stirred for 15 hr. The solution was cooled to 0°C, then quenched by addition of satd. NaHCO3 until a pH of 8-9 was reached. The aqueous layer was separated and extracted with 3x20 mL of methylene chloride. The organics were combined, treated with 10 mL of HCI (1.0 M in ether), dried and concentrated to leave a solid residue. The material was dissolved in 70 mL of t-butanol, K2CO3 (1 g) was added, and the mixture was heated at reflux for 1.5 hr. Nal (1 g) was then added, and the mixture stirred a further 2.5 hr at reflux. The mixture was cooled and filtered, and the solvent was removed under vacuum. The crude product was dissolved in methylene chloride, which was filtered, washed and concentrated. The residue was purified by preparative tic, eluting with 25:1 methylene chloride:methanol containing 5%NH4OH, to give 151 mg of the title compound as a solid. MS: 329(M+H)+, 346(M+NH )+. NMR (CDCI 3 ) δ: 7.45 (s, 1 H), 6.64 (s, 1 H), 3.95 (m, 3H), 3.91 (s, 3H), 3.87 (s, 3H), 2.99 (m, 3H), 2.81 (t, J=8 Hz, 2H), 2.14 (m, 1 H), 1.90 (m, 2H), 1.85 (sx, J=8 Hz, 2H), 1.03 (t, J=8 Hz, 3H). 29g. frans-2-Propvl-4.5.5a.6.7.11 b-hexahvdro-1 -oxa-3.5-diaza- cvclopentarφhenanthrene-9.10-diol di hvdrobromide Following the procedures of Example 1f, a 120 mg (0.366 mmol) sample of the compound from step 29f above was treated with BBr3 and methanol, and 170 mg of the title product was isolated, mp. 225°C (dec). MS: 301 (M+H)+, 318 (M+NH 4 ) + . NMR (CDCI3) δ: 7.31 (s, 1 H), 6.61 (s, 1 H), 4.44-4.22 (m, 3H), 3.63 (m, 1 H), 3.00 (m, 2H), 2.88 (t, J=8 Hz, 2H), 2.37 (m, 1 H), 2.08 (m, 1 H), 1.88 (t, J=8 Hz, 2H), 1.04 (t, J=8 Hz, 3H). Anal. Calcd for Ci7H oN2θ 3 '2.3 HBM.O H 0: C, 40.48; H, 4.86; N, 5.55; Found: C, 40.56; H, 5.08; N, 5.42. Example 30 frans-2-(3-Methvlbutvh-4.5.5a.6.7.11 b-hexahvdro-1 -thia-5-aza- cvclopenta[φhenanthrene-9.10-diol hvdrobromide 30a. 2-(3-Methvlbutvnthiophene Isopentyl bromide (Aldrich, 8g, 53mmol) was added to 53 mL of an ice- cooled solution of lithiothiophene (1.0 M in THF, 53mmol). The reaction was stirred at 0°C for 2 hr, at room temperature for 16 hr, and poured into water, then the mixture was extracted with hexane. The organic layer was dried and concentrated, and the residue was purified by column chromatography on silica gel, eluting with hexane, to give 7.2 g (88% yield) of the title compound as a colorless oil. NMR (CDCI3) δ: 7.10 (dd, J=1 , 6 Hz, 1 H), 6.90 (dd, J=4, 6 Hz, 1 H), 6.78 (dd, J=1 , 4 Hz, 1 H), 2.84 (t, J=8 Hz, 2H), 1.7-1.5 (m, 3H), 0.94 (d, J=6 Hz, 6H). 30b. frans-2-(3-Methvlbutyn-4.5.5a.6.7.11 b-hexahvdro-1 -thia-5-aza- cvclopenta[c]phenanthrene-9.10-diol hvdrobromide Following the procedures of Example 1 , substituting 2-isopentylthiophene, from step 30a above, for the 2-methylthiophene of Example 1c, the title compound was prepared, mp. 215-219°C. MS: 344 (M+H)+. NMR (CD3OD) δ: 7.32 (s, 1 H), 6.71 (s, 1 H), 6.62 (s, 1 H), 4.35 (bs, 2H), 4.29 (d, J=11 Hz, 1 H), 3.35- 3.38 (m, 1 H), 2.95-2.80 (m, 4H), 2.4-2.28 (m, 1 H), 2.05-1.90 (m, 1H), 1.7-1.55 (m, 3H), 0.95 (d, J=6 Hz, 6H). Anal. Calcd for C 2 oH26BrNO 2 S « 0.3 CH 2 CI 2 : C, 54.19; H, 5.96; N, 3.11 ; Found: C, 54.00; H, 5.76; N, 3.20. Example 31 frans-2-Hexvl-4.5.5a.6.7.11 b-hexahvdro-1-thia-5-aza- cyclopentarclDhenanthrene-9.10-diol hvdrobromide Following the procedures in Example 30, substituting n-hexyi iodide for isopentyl bromide in step 30a, the title compound was prepared, mp. 165-170°C. MS: 358 (M+H)+. NMR (CD 3 OD) δ: 7.32 (s, 1 H), 6.7 (s, 1 H), 6.61 (s, 1 H), 4.37 (s, 2H), 4.31 (d, J=11 Hz, 1 H), 3.42 (ddd, J=6, 11 , 11 Hz, 1 H), 3.0-2.9 (m, 2H), 2.82 (t, J=7 Hz, 2H), 2.4-2.3 (m, 1 H), 2.05-1.9 (m, 1 H), 1.72-1.6 (m, 2H), 1.4-1.2 (m, 6H), 0.94 (m, 3H). Example 32 fra/7s-2-Chloro-4.5.5a.6.7.11 b-hexahvdro-1-thia-5-aza- cvclopenta[φhenanthrene-9.10-diol hvdrobromide Following the procedures of Example 1c-1f, substituting 2-chlorothiophene for 2-methylthiophene and lithium diisopropylamide for n-butyl lithium in step 1c, the title compound was prepared, mp. 261-263°C. MS: 308 (M+H)+. NMR (CD3OD) δ: 7.18 (s, 1 H), 6.95 (s, 1 H), 6.52 (s, 1 H), 4.39 (s, 2H), 4.33 (d, J=11 Hz, 1 H), 3.46 (ddd, J=5, 11 , 11 Hz, 1 H), 2.95-2.88 (m, 2H), 2.4-2.27 (m, 1 H), 2.05- 1.85 (m, 1 H). Anal. Calcd for Ci5Hi5BrCINO2SO.1 H O: C, 46.14; H, 3.92; N, 3.59; Found: C, 46.02; H, 3.91 ; N, 3.56. Example 33 fraπs-2-(1 -Cvclopentvlmethvn-4.5.5a.6.7.11 b-hexahvdro-1 -thia-5-aza- cvclopenta[φhenanthrene-9.10-diol hvdrobromide 33a. 2-Thienvl cvclopentyl ketone Cyclopentanecarboxylic acid chloride, prepared from 100 mmol cyclopentanecarboxylic acid and 120 mmol of thionyl chloride, was dissolved in 100 mL of methylene chloride, and the solution was cooled in an ice bath. Thiophene (13.4 mL, 100 mmol) and SnCU (25 mL of a 1 M solution in methylene chloride) were added. The reaction was warmed to room temperature and stirred for 72 hr. The reaction was quenched with 1 N HCI, and the mixture was extracted with three portions of methylene chloride. The organic extract was washed with satd aqueous NaHC03, was dried over MgSθ4, and filtered through a pad of silica gel. The solvent was removed by rotary evaporation to give 12.28 g of crude product, which was used without further purification. 33b. 2-CvcloDentvlmethvthiophene The material from step 33a above (12.28 g ) was dissolved in 100 mL of diethylene glycol. KOH (11.20 g, 200 mmol) was added and dissolved. Hydrazine hydrate (a8.25 mL, 170 mmol) was added, and the reaction was heated to gentle reflux for 18 hr. After cooling, the reaction was diluted with water, neutralized with 66 mL of 3 N HCI and extracted with 3x 100 mL of hexane. The extract was dried over MgSθ4 , filtered through a pad of silica gel and evaporated on a rotary evaporator to give 6.58 g of the title product . NMR (CDCI 3 ) δ: 1.21 (m, 2H), 1.61 (m, 4H), 1.81 (m, 2H), 2.14 (septet, 1H), 2.81 (d, 2H), 6.79 (dd, J=1 , 4 Hz, 1 H), 6.91 (dd, J=4, 5 Hz, 1 H), 7.11 (dd, J=1 , 5 Hz, 1 H). 33c. fraπs-2-M-Cyclopentvlmethvl .5.5a.6.7.11b-hexahvdro-1-thia-5-aza- cvclopenta[c]phenanthrene-9.10-diol hvdrobromide Following the procedures of Example 1 , replacing 2-methyfthiophene of step 1c with 2-cyclopentylmethythiophene, prepared in step 33a above, the title compound was prepared, mp. 180-185°C. MS: 356 (M+H)+. NMR (CD3OD) δ: 7.34 (s, 1 H), 6.71 (s, 1 H), 6.64 (s, 1H), 4.38 (s, 2H), 4.29 (d, J=11 Hz, 1 H), 3.42 (ddd, J=6, 11 , 11 Hz, 1 H), 3.0-2.8 (m, 2H), 2.83 (d, J=8 Hz, 2H), 2.4-2.26 (m, 1 H), 2.22-2.1 (m, 1 H), 2.0-1.55 (m, 7H), 1.35-1.2 (m, 2H). Anal. Calcd for C22H26BrCINO 2 SO.15 HBr » 0.15 EtOH: C, 56.19; H, 5.95; N, 3.08; Found: C, 56.37; H, 5.84; N, 2.87. Example 34 ttaπs-2-lsopropvl-4.5.5a.β.7.11 b-hexahvdro-1-thia-5-aza- cvclopentarφhenanthrene-9.10-diol trifluoroacetate salt 34a. 2-lsopropvl-4-thiophene carboxaldehvde AICI3 (4 g, 35.6 mmol) and 2-chloropropane (Aldrich, 1.3 g, 17 mmol) were sequentially added to an ice-cold solution of 3-thiophenecarboxaldehyde (Aldrich Chemical Co.), and the resulting mixture was stirred at room temperature for 16 hr. The reaction mixture was poured onto ice, and the resulting mixture was adjusted to pH 12 with 20% NaOH and extracted 4x with methylene chloride. The organic extract was washed with H2O and brine, dried over MgSθ4 and concentrated. Column chromatography on silica gel, eluting with 15:1 hexane .ethyl acetate, afforded 310 mg of the title compound. NMR (CDCI3) δ: 9.82 (s, 1 H), 7.92 (s, 1 H), 7.24 (s, 1 H), 3.2-3.1 (m, 1 H), 1.34 (d, J=8 Hz, 6H). 34b. 2-lsopropyl-4-thiophene carboxylic acid A solution of AgNOβ (1.01 g, 5.92 mmol) in 10 mL of H20 and 15 mL of a solution of KOH (1.63 g, 40.8 mmol) were sequentially added to a solution of 760 mg (4.9 mmol) of 2-isopropyl-4-thiophene carboxaldehvde, from step 34a above, in 25 mL of ethanol. The resulting black mixture was stirred at room temperature for 2 hr and filtered. The filtrate was washed with ether, then acidified with 6N HCI and extracted with ether. The extract was washed with H2O and brine, dried over MgSO4 and concentrated to give 680 mg (81%) of the title compound as a yellow solid, mp. 64-67°C. 34c. rrans-2-lsopropvl-4.5.5a.6.7.11 b-hexahvdro-1 -thia-5-aza- cyclopenta[φhenanthrene-9.10-diol trifluoroacetate salt Following the procedures in Example 2a-g, substituting 2-isopropyl-4- thiophene carboxylic acid for the 3-thiophene carboxylic acid of step 2a, the title compound was prepared. The compound was further purified on a reverse phase HPLC column , eluting with 50:50 methanol:0.1% TFA. mp. 192-195°C. MS: 316 (M+H)+. NMR (CD3OD) δ: 7.34 (s, 1 H), 6.72 (s, 1 H), 6.62 (s, 1 H), 4.34 (s, 2H), 4.26 (d, J=11 Hz, 1 H), 3.45-3.35 (m, 1 H), 3.25-3.10 (m, 1 H), 2.95-2.85 (m, 2H), 2.4-2.28 (m, 1 H), 2.0-1.88 (m, 1 H), 0.85 (d, J= 6 Hz, 6 H). Anal. Calcd for C20H22F3NO4S: C, 54.18; H, 4.95; N, 3.10; Found: C, 54.22; H, 5.02; N, 3.27. Example 35 frat7s-2-(3-Methvlbutvh-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cyclopenta[φhenanthrene-9.10-diol hvdrobromide 35a. 5-(3-Methvlbutvn-2-thiophenecarboxvlic acid. N-t-butvl amide Following the procedure of Example 5a, replacing the 2-propylthiophene of step 5a with 2-(3-methylbutyl)thiophene, prepared in Example 30a, the title compound was prepared. MS: 254 (M+H)+, 271 (M+NH 4 )+. NMR (CDCI3) δ: 7.24 (d, J=4 Hz, 1 H), 6.72 (d, J=4 Hz, 1 H), 5.7 (bs, 1 H), 2.82 (t, J= 8 Hz, 2H), 1.7- 1.5 (m, 3H), 1.44 (s, 9H), 0.93 (d, J=6 Hz, 6H). 35b. 3-f2-Amino-6.7-dimethoxy-1.2.3.4-tetrahvdro-2-naphthalenvn-5-r3- methvlbutyh-2-thioρhenecarboxylic acid. N-t-butvl amide Following the procedures of Example 3c-d, the compound from step 35a was converted to the title product. MS: 459 (M+H)+. NMR (CDCI3) δ: 6.60 (s, 1 H), 6.30 (s, 1 H), 6.20 (s, 1 H), 4.51 (d, J=10 Hz, 1 H), 3.86 (s, 3H), 3.64 (s, 3H), 3.36-3.25 (m, 1 H), 3.1-2.8 (m, 2H), 2.70 (t, J=9 Hz, 2H), 2.3-2.2 (m, 1H), 2.0-1.85 (m, 1 H), 1.7-1.5 (m, 3H), 1.42 (s, 9H), 0.89 (d, J=6 Hz, 3H), 0.88 (d, J=6 Hz, 3H). 35cJrans-2-f3-Methvlbutvn-4.5.5a.6.7.11 b-hexahvdro-3-thia-4-oxo-5-aza-9.10- dimethoxv-cvclopentafφhenanthrene To a solution of 1.87 g (4.1 mmol) of the compound from step 35b above in 100 mL of toluene was added toluenesulfonic acid monohydrate (1.55 g, 8.2 mmol), and the reaction was stirred at reflux for 48 hr. The reaction was cooled to room temperature, diluted with ethyl acetate, and washed with aqueous 58 SUBSTITUTE SHEET (RULE 26^ NaHC03, H2O and brine, then dried over Na2SO4 and concentrated under vacuum. The crude product was crystallized from ethanol to give 0.91 g (60% yield) of the title compound as a white solid. MS: 386 (M+H) + , 403(M+NH ) + . NMR (CDCI3) δ: 7.14 (s, 1 H), 7.13 (s, 1 H), 6.67 (s, 1 H), 5.95 (s, 1 H), 4.14 (d, J=12 Hz, 1 H), 3.94 (s, 3H), 3.88 (s, 3H), 3.75 (ddd, J=3, 12, 12 Hz, 1H), 3.0-2.76 (m, 4H), 2.1-1.9 (m, 2H), 1.7-1.55 (m, 3H), 0.95 (d, J=6 Hz, 6H). 35dJrans-2-f3-Methvlbutvh-4.5.5a.6.7.11 b-hexahydro-3-thia-5-aza-9.10- dimethoxv-cvclopentarφhenanthrene Following the procedure of Example 3g, substituting the compound from step 35 c for the starting material thereof, the compound of step 35c was converted to the title compound, mp. 110-112°C. MS: 372 (M+H)+. NMR (CDCI3) δ: 7.0 (s, 1 H), 6.89 (s, 1 H), 6.72 (s, 1 H), 4.05 (s, 2H), 3.88 (s, 3H), 3.82 (s, 3H), 3.56 (d, J=11 Hz, 1 H), 3.0-2.6 (m, 5 H), 2.3-2.15 (m, 1 H), 1.8-1.5 (m, 4H), 0.95 (d, J=6 Hz, 6H). Anal. Calcd for C22H29NO2S: C, 71.12; H, 7.87; N, 3.77; Found: C, 70.72; H, 7.76; N, 3.75. 35eJra/75-2-(3-Methvlbutvl)-4.5.5a.6.7.11 b-hexahydro-3-thia-5-aza- cvclopenta[φhenanthrene-9.10-diol hydrobromide Following the procedures of Example 3h, substituting the compound from step 35d for the starting material thereof, the title compound was prepared, mp. 73-75°C. MS: 344 (M+H)+. NMR (CDCI3) δ: 7.01 (s, 1 H), 6.98 (s, 1 H), 6.67 (s, 1 H), 4.45 (s, 2H), 4.0 (d, J=11 Hz, 1 H), 3.28-3.15 (m, 1 H), 3.0-2.8 (m, 4H), 2.4- 2.25 (m, 1 H), 2.0-1.8 (m, 2H), 1.7-1.58 (n, 2H), 0.98 (d, J=6 Hz, 6H). Anal. Calcd for C2oH26BrNO 2 SO.5 H 2 O: C, 55.43; H, 6.28; N, 3.23; Found: C, 55.43; H, 6.29; N, 3.27. Example 36 at7S-2-Pentvl-4.5.5a.6.7.11 b-hexahydro-3-thia-5-aza- pyp|ppenta[p]phenanthrene-9.10-diol hydrpbrpmide Following the procedures of Example 35, substituting 2-pentylthiophene (prepared as in Example 30a starting with pentyl iodide in place of isopentyl bromide) for 2-(3-methylbutyl)thiophene, the title compound was prepared, mp. 78-80°C. MS: 344 (M+H)+. NMR (CD3OD) δ: 7.01 (s, 1 H), 6.89 (s, 1 H), 6.66 (s, 1 H), 4.46 (bs, 2H), 4.02 (d, J=11 Hz, 1 H), 3.3-3.15 (m, 1 H), 3.05-2.8 (m, 4H), 2.4- 2.3 (m, 1 H), 2.0-1.9 (m, 1 H), 1.8-1.65 (m, 2H), 1.5-1.3 (m, 4H), 0.94 (t, J=6Hz, 3H). Anal. Calcd for C20H26BrNO2SO.8H2OO.I HBr: C, 53.75; H, 6.25; N, 3.13; Found: C, 53.69; H, 6.12; N, 3.06 Example 37 traπs-2-f2-Thiophenvn-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopentarclDhenanthrene-9.10-diol hvdrobromide Following the procedures of Example 35, substituting 2,2'-bithiopheno (Aldrich) for 2-(3-methylbutyl)thiophene, the title compound was prepared, mp. 227-229°C. MS: 356 (M+H)+. NMR (CD 3 OD) δ: 7.42 (dd, J=1 , 6 Hz, 1 H), 7.32 (dd, J=1 , 4 Hz, 1 H), 7.08 (dd, J=4,6 Hz, 1 H), 6.93 (s, 1 H), 6.68 (s, 1 H), 4.58 (d, J=15 Hz, 1H), 4.48 (d, J=15 Hz, 1 H), 4.1 (d, J=11 Hz, 1H), 3.3-3.2 (m, 1H), 3.05- 2.9 (m, 1 H), 2.9-2.8 (m, 1 H), 2.42-2.3 (m, 1 H), 2.05-1.9 (m, 1 H). Anal. Calcd for Cι 9 Hι 8 BrNθ2S2*0.7 H20: C, 50.83; H, 4.35; N, 3.12; Found: C, 50.80; H, 4.40; N, 3.13. Example 38 rraπs-2-Hexyl-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopenta[φhenanthrene-9.10-diol TFA salt Following the procedures of Example 35, substituting 2-hexylthiophene for 2-(3-methylbutyl)thiophene, the title compound was prepared. The compound was further purified by reverse-phase HPLC on a semipreparative column, eluting with a 1 :1 mixture of methanol:0.1% aqueous TFA. mp. 90-97°C (dec). MS: 358 (M+H)+. NMR (CD 3 OD) δ: 7.01 (s, 1 H), 6.88 (s, 1 H), 6.66 (s, 1 H), 4.45 (s, 2H), 4.0 (d, J=11 Hz, 1 H), 3.28-3.18 (m, 1 H), 2.95-2.85 (m, 4H), 2.4-2.3 (m, 1H), 2.0-1.85 (m, 1 H), 1.8-1.65 (m, 2H), 1.5-1.3 (m, 6H), 0.95-0.88 (m, 3H). Example 39 frat7S-2- CvclODentvlmethvn-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopenta[φhenanthrene-9.10-diol hvdrobromide Following the procedures of Example 35, substituting 2-(cyclopentylmethyl)thiophene, from Example 33b, for 2-(3- methylbutyl)thiophene, the title compound was prepared, mp. 198-205°C (dec). MS: 356 (M+H)+. NMR (CD3OD) δ: 7.02 (s, 1 H), 6.89 (s, 1 H), 6.68 (s, 1 H), 4.45 (s, 2H), 4.02 (d, J=11 Hz, 1 H), 3.3-3.15 (m, 1 H), 3.05-2.8 (m, 2H), 2.88 (d, J=7 Hz, 2H), 2.4-2.28 (m, 1 H), 2.24-2.15 (m, 1 H), 2.0-1.4 (m, 7H), 1.35-1.2 (m, 2H). Anal. Calcd for C2iH26BrN0 SO.2 HBr » 0.2EtOH: C, 55.66; H, 5.98; N, 3.03; Found: C, 55.80; H, 5.92; N, 2.92. Example 40 trans-2-Ethvl-4.5.5a.6.7.11b-hexahvdro-3-oxa-5-aza-cvclθDentarc1ohenanthrenfi- 9.1 Q-diPl hydrpphlpride 40a. 1.2-Dihvdro-6.7-methvlenedioxv-3-nitronaGhthalene Following the procedures of Example 1a-b, replacing 6,7-dimethoxy-1- tetralone of step 1a with 6, 7-methylenedioxy-1 -tetralone (prepared as described by Zjawiony and Peterson, Organic Preparations and Procedures Int., 22.163- 172, 1991) the title compound was prepared. MS: 220(M+H) + , 237(M+NH 4 )+. NMR (CDCI 3 ) δ: 7.78 (s, 1 H), 6.80 (s, 1 H), 6.72 (s, 1 H), 6.01 (s, 2H), 2.46 (bs, 4H). 40b. fraπs-2-Ethyl-4.5.5a.6.7.11 b-hexahvdro-3-oxa-4-oxo-5-aza-9.10- methvlenedioxv-cyclopentafφhenanthrene Following the procedures in Example 35a-c, substituting 2-ethylfuran (Aldrich) for the 2-(3-methylbutyl)thiophene of step 35a, and substituting the compound from step 40a above for the 1 ,2-dihydro-6,7-dimethoxy-3-nitro- naphthalene starting material of step 35b, the title compound was prepared. MS: 312(M+H)+, 329 (M+NH 4 ) + . NMR (CDCI3) δ: 7.09 (s, 1 H), 6.64 (s, 1H), 6.47 (s, 1 H), 5.97 (m, 2H), 5.44 (bs, 1 H), 4.03 (d, J=12 Hz, 1 H), 3.77-3.66 (m, 1H), 3.0- 2.84 (m, 2H), 2.77 (q, J=8 Hz, 2H), 2.08-1.88 (m, 2H), 1.31 (t, J=8 Hz, 3H). 40c. frat7S-2-Ethyl-4.5.5a.6.7.11 b-hexahvdro-3-oxa-5-aza-9.10-methvlenedioxv- cvclopentafφhenanthrene A solution of 40b (218 mg, 0.7 mmol) in 20 mL of THF was added to a suspension of LAH (34 mg, 0.9 mmol) in 20 mL of THF, and the reaction mixture was stirred at reflux for 16 hr. An additional 34 mg of LAH was added, and the reaction was stirred at reflux for 2 hr. The mixture was cooled to room temperature, quenched with solid Na2Sθ4 « 10H2O, filtered and concentrated. The residue was purified by column chromatography on silica gel, eluting with 70:30 ethyl acetate :hexane to give 80 mg (38% yield) of the title compound after removal of the solvent and drying. NMR (CDCI3) δ: 7.02 (s, 1 H), 6.66 (s, 1H), 6.23 (s, 1 H), 5.9 (m, 2H), 3.92 (m, 2H), 3.51 (d, J=11 Hz, 1 H), 2.86 (q, J=7 Hz, 2H), 2.7- 2.6 (m, 3H), 2.2-2.1 (m, 1H), 1.7-1.5 (m, 1H), 1.20 (t, J=7 Hz, 3H). 40d. fraπs-2-Ethvl-4.5.5a.6.7.11 b-hexahvdro-3-oxa-5-aza-cvclopenta[c]- phenanthrene-9.10-diol hydrochloride The compound from step 40c (80 mg, 0.26 mmol) was dissolved in 5 mL of methylene chloride, and the solution was cooled in an ice bath. BCI3 (2.6 mL of a 1 M solution in methylene chloride) was added. The reaction was stirred 2 hr at 0°C, then quenched with 5 mL of methanol. The quenched reaction mixture was allowed to warm to room temperature, then stirred for 16 hr. The solvent was removed by rotary evaporation, and the residue was dried under high vacuum. 61 SUBSTITUTE SHEET (RULE 2.6) The dried residue was triturated with diethyl ether, and the product was collected by filtration. A 74 mg sample of the title product was obtained after drying under high vacuum, mp. 252-255°C. MS: 286 (M+H) + . NMR (CD 3 OD) δ: 7.03 (s, 1 H), 6.64 (s, 1 H), 6.49 (s, 1H), 4.38-4.30 (m, 2H), 3.96 (d, J=11 Hz, 1 H), 3.3-3.2 (m, 1 H), 3.0-2.9 (m, 2H), 2.72 (q, J=8 Hz, 2H), 2.4-2.25 (m, 1 H), 2.05-1.88(m, 1 H), 1.3 (t, J=8 Hz, 3H). Anal. Calcd for Ci7H 2 oCIN0 3 » 0.4 HCI: C, 60.70; H, 6.11 ; N, 4.16; Found: C, 60.61 ; H, 5.97; N, 4.06. Example 41 rrans-2-Propyl-4.5.5a.6.7.11b-hexahvdro-3-oxa-5-aza- cyclopenta[φhenanthrene-9.10-diol hydrochloride Following the procedures of Example 40, substituting 2-propylfuran (K&K) for the 2-ethylfuran of step 40b, the title compound was prepared, mp. 176- 181 °C. MS: 300(M+H)+. NMR (CD 3 OD) δ: 7.03 (s, 1 H), 6.83 (s, 1 H), 6.50 (s, 1H), 4.38-4.32 (m, 2H), 3.97 (d, J=11 Hz, 1 H), 3.3-3.2 (m, 1 H), 3.0-2.88 (m, 2H), 2.68 (t, J=7 Hz, 2H), 2.4-2.35 (m, 1H), 2.05-1.9 (m, 1H), 1.72 (sx, J=7 Hz, 2H), 1.0 (t, J=7 Hz, 3H). Anal. Calcd for Cι 8 H22CINO 3 « 0.7 H 2 0: C, 62.05; H, 6.77; N, 4.02; Found: C, 62.04; H, 6.65; N, 3.95. Example 42 fraπs-2-Phenvl-4.5.5a.6.7.11 b-hexahvdro-3-oxa-5-aza- cvclopenta[c1phenanthrene-9.10-diol hydrochloride Following the procedures of Example 40, substituting 2-phenylfuran (prepared according to Pelter et al., Synthesis, 1987:51) for the 2-ethylfuran of step 40b, the title compound was prepared, mp. 210-215°C (dec). MS: 334 (M+H)+. NMR (CD 3 OD) δ: 7.76 (dd, 1 , 6 Hz, 2H), 7.5-5.4 (m, 3H), 7.22 (s, 1 H), 7.12 (s, 1H), 6.66 (s, 1 H), 4.5 (bs, 2H), 4.05 (d, J=11 Hz, 1H), 3.4-3.3 (m, 1 H), 3.0- 2.9 (m, 2H), 2.42-2.3 (m, 1H), 2.1-1.95 (m, 1H). Anal. Calcd for C2iH 2 oCIN0 3 »0.3 HCN).5 H 0: C, 64.71 ; H, 5.51 ; N, 3.59; Found: C, 64.69; H, 5.51 ; N, 3.59. Example 43 frat7S-3-Propvl-4.5.5a.6.7.11 b-hexahvdro-2-thia-5-aza- cvclopentafφhenanthrene-9.10-diol TFA salt 43a, 4-Brpmp-2-prppyl-3-thippheπeparbpχaldehyde To a solution of diisopropylamine (2.7 mL, 19.4 mmol) in 50 mL of THF cooled to -78°C was added 7.8 mL (2.5 M in hexane, 19.4 mmol) of n- butyllithium, and the reaction was stirred for 0.5 hr. To the first solution was added 4.7 g (19.4 mmol) of 3,4-dibromothiophene (Aldrich), then the reaction mixture was stirred for 1 hr at -78°C. lodopropane (2.8 mL, 29.1 mmol) was then added, the reaction stirred for 10 min at -78°C, then removed for the cooling bath and stirred for 2 hr at room temperature. The reaction was quenched with aqueous satd. NH4CI, extracted with ether, washed with H20 and brine, and concentrated to give 5.27 g of crude 3,4-dibromo-2-propylthiophene. This compound (5.25 g, 18.5 mmol) was dissolved in 80 mL of ether and cooled to -78 °C. n-Butyllithium (7.4 mL, 18.5 mmol) was added dropwise via syringe, and the resulting mixture was stirred at -78°C for 20 min. DMF was added (1.86 mL, 24.03 mmol), and the reaction was stirred at -78°C for 1 hr, then poured into water and extracted with ether. The extract was washed with water, dried over MgSU4, and concentrated in vacuo. Silica gel column chromatography afforded 0.63 g of the title compound. NMR (CDCI3) δ: 10.07 (s, 1 H), 7.09 (s, 1 H), 3.20 (t, J=7 Hz, 2H), 1.74 (m, 2H), 1.02 (t, J=7 Hz, 3H). 43b. 4-Bromo-2-propvl-3-thiophenemethanol A 850 mg (3.6 mmol) sample of the compound from step 43a was dissolved in 20 mL of ethanol and treated with 206 mg (5.4 mmol) of sodium borohydride. The mixture was stirred at room temperature for 1 hr, then quenched with water and extracted with ether. The extract was washed with water, dried over MgSU4, and concentrated in vacuo to give 950 mg of an oil that was taken to the next step without further purification. NMR (CDCI3) δ: 7.09 (s, 1H), 4.60 (s, 2H), 2.85 (t, J=7 Hz, 2H), 1.68 (m, 2H), 0.99 (t, J=7 Hz, 3H). 43c. 4-Bromo-3-((methoxv^methoxvmethvh-2-propvlthiophene To a solution of the compound from step 43b above (3.6 mmol) in 20 mL of methylene chloride was added 1.4 mL (8.1 mmol) and 0.46 mL, 6 mmol) of chloromethyl methyl ether. The reaction mixture was stirred at room temperature for 16 hr, diluted with ether, washed with water and brine, then dried over MgSθ4 concentrated. The residue was purified by chromatography on silica gel, eluting with 20:1 hexane:ethyl acetate, to afford 754 of the title compound. NMR (CDCI3) δ: 7.09 (s, 1 H), 4.69 (s, 2H), 4.52 (s, 2H), 3.44 (s, 3H), 2.88-2.82 (m, 2H), 1.75-1.62 (m, 2H), 0.99 (t, J=7 Hz, 3H). 43d. 4-(6.7-Dimethoxv-2-nitro-1.2.3.4-tetrahvdronaphalenvn-3- «methoxv methoxvmethvlV2-propvlthiophene Following the procedure of Example 29d, replacing the starting material of Example 29d with the compound from step 43c above, the title compound was prepared. MS: 453 (M+H)+. NMR (CDCI3) δ: 6.59 (s, 1 H), 6.56 (s, 1 H), 6.39 (s, 1 H), 5.2-5.15 (m, 1H), 4.91 (d, J=6 Hz, 1 H), 4.63 (d, J=6 Hz, 1 H), 4.58 (d, J=6 Hz, 1 H), 4.48 (d, J=11 Hz, 1 H), 4.35 (d, J=11 Hz, 1 H), 3.86 (s, 3H), 3.68 (s, 3H), 3.37 (s, 3H), 2.95-2.85 (m, 2H), 2.81 (t, J=7 Hz, 2H), 2.5-2.3 (m, 2H), 1.68 (sx, J=7 Hz, 2H), 0.97 (t, J=7 Hz, 3H). 43e. 4-(2-Amino-6.7-dimethoxv-1.2.3.4-tetrahvdronaphalenvh-3- ^methoxv^methoxvmethvn-2-DroDvlthiθDhene Following the procedures of Example 3d, replacing the starting material therein with the compound (380 mg, 0.9 mmol) from step 43d above, the title compound was prepared. MS: 406 (M+H)+. NMR (CDCI 3 ) δ: 6.67 (s, 1 H), 6.59 (s, 1 H), 6.28 (s, 1 H), 4.58 (s, 2H), 4.41 (d, J=11 Hz, 1 H), 4.31 (d, J=11 Hz, 1 H), 3.9-3.8 (m, 4H), 3.63 (s, 3H), 3.38 (s, 3H), 3.34-3.25 (m, 1 H), 2.92-2.8 (m, 4H), 2.15-2.0 (m, 1 H), 1.8-1.6 (m, 3H), 0.99 (t, J=7 Hz, 3H). 43f. 9.10-Dimethoxv-3-propvl-4.5.5a.6.7.11 b-hexahvdro-2-thia-5-aza- cvclopentafφhenanthrene A solution of the compound (0.9 mmol) from step 43e above was dissolved in 10 mL of THF, 0.5 mL of 12 HCI was added, and the mixture was stirred at reflux for 1.5 hr. Removal of the solvent, gave the intermediate chloro compound, which was immediately dissolved in t-butanol, treated with Na2Cθ3 (1.0 g, 7.1 mmol) and stirred at reflux for 30 min. The mixture was cooled to room temperature, poured into water, and extracted with methylene chloride. The solvent was dried and removed by evaporation. The residue was purified by silica gel chromatography, eluting with methylene chloride:methanol 97:3, to afford 184 mg of the title compound. MS: 344 (M+H)+. NMR (CDCI3) δ: 7.23 (s, 1 H), 7.10 (d, J=1 Hz, 1 H), 6.80 (s, 1 H), 4.13 (d, J=15 Hz, 1 H), 3.95 (d, J=15 Hz, 1 H), 3.88 (s, 3H), 3.87 (s, 3H), 3.71 (d, J=11 Hz, 1H), 3.60-3.52 (m, 1H), 2.88 (t, J=7 Hz, 2H), 2.75-2.65 (m, 2H), 2.22-2.10 (m, 1 H), 1.9-1.6 (m, 3H), 1.0 (t, J=7 Hz, 3H). 43q. 3-Propvl-4.5.5a.6.7.11 b-hexahvdro-2-thia-5-aza- cvclopentarφhenanthrene-9.10-diol trifluoroacetate salt Following the procedures of Example 1f, substituting the compound of step 43f above for the starting material therein, the title compound was obtained as a mixture of the cis and trans isomers. The mixture was purified by reverse phase HPLC, eluting with 1 :1 methanol:0.1%TFA to give the trans isomer. mp. 114-116°C. MS: 316 (M+H)+. NMR (CD3OD) δ: 7.27 (d, J=1 Hz, 1 H), 7.11 (s, 1 H), 6.64 (s, 1 H), 4.43 (d, J=14 Hz, 1 H), 4.34 (d, J=14 Hz, 1 H), 4.10 (d, J=11 Hz, 1H), 3.14 (td, J=11 ,6 Hz, 1 H), 2.9-2.75 (m, 4H), 2.35-2.24 (), 1 H), 2.0-1.85 (m, 1 H), 1.71 (sx, J=7 Hz, 2H), 1.02 (t, J=7 Hz, 3H). Comparative Example 44 2-Propvl-4.5.5a.6.7.11 b-hexahvdro-1 -thia-5-aza-cvclopentarφhenanthrene-10-ol hydrobromide Following the procedures as described in Example 1 above, substituting 7- methoxy-1 -tetralone for the 6,7-dimethoxy-1 -tetralone of step 1a thereof and substituting 2-ethylthiophene for 2-methylthiophene of step 1c thereof, the title compound was prepared. mp 234-236°C. MS: 286 (M+H)+. NMR (CD 3 OD) δ: 7.33 (d, 1 H, J=3 Hz), 7.04 (d, 1 H, J=9 Hz), 6.73 (s, 1 H), 6.68 (dd, 1 H, J=3, 9 Hz), 4.4-4.3 (m, 3H), 3.5-3.35 (m, 1 H), 2.96 (t, 2H, J=7 Hz), 2.88 (q, 2H, J=8 Hz), 2.4-2.3 (m, 1 H), 2.05-1.9 (m, 1 H), 1.33 (t, 3 H, J=8 Hz). Anal. Calc'd for Ci7H 2 oBrNO 2 S » 0.3 H 2 O: C, 54.93; H, 5.58; N, 3.77; Found: C, 54.66; H, 5.22; N, 3.85; Comparative Example 45 2-'3-Methvlphenvn-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopθnta[φhenanthrene-9.10-diol hvdrobromide n-Butyllithium (15 mL, 2.5 M in hexane, 37.4 mmol) was added dropwise to a solution of 3-bromotoluene (5.8 g, 34.0 mmol) in 50 mL of THF cooled to -78°C. The resulting suspension was stirred at -78°C for 30 min, treated with trimethyl borate (10.6 g, 102.2 mmol), stirred -78°C for 10 min, and allowed to warm to room temperature. The reaction mixture was stirred at room temperature for 16 hr, then cooled in an ice bath and acidified to pH 6 with 2N HCI. The mixture was extracted with methylene chloride, and the organic extract was washed with brine, dried over Na2Sθ4, and concentrated to yield 4.24 g of 3-methylphenyl boronic acid. 5-Bromo-2-thiophenecarboxaldehyde (5.09 g, 26.2 mmol) was added to a suspension of 907 mg (0.78 mmol) of tetrakis(triphenylphosphine) palladium (0) in 50 mL of DME, and the resulting mixture was stirred at room temperature for 15 min. To this mixture was added a solution of the 3-methylphenyl boronic acid (prepared above) in 10 mL of ethanol and 26 mL of 2M aqueous Na2Cθ3. The reaction was stirred at reflux for 24 hr, then cooled to room temperature, diluted, and extracted with ether. The organic extract was washed with water and brine, dried over MgS04, and concentrated. The residue was purified by flash chromatography on silica gel, eluting with 5% ethyl acetate in hexane, to give 4.75 g. (90% yield) of 5-(3- methylphenyl)-2-thiophenecarboxaldehyde. MS: 203 (M+H)+ 220 (M+NH )+. NMR (CDCI3) d: 9.89 (s, 1 H), 7.74 (d, 1H, J=5 Hz), 7.55-7.20 (m, 5H), 2.42 (s, 3H). A solution of 5-(3-methylphenyl)-2-thiophenecarboxaldehyde (prepared immediately above, 4.7 g, 23.3 mmol) was dissolved in 100 mL of ethanol and sequentially treated with a solution of silver nitrate (7.9 g, 116.5 mmol) in 15 mL of water. The suspension was stirred at room temperature for 1 hr, then filtered, and the filter cake was washed with water and ether. The filtrate was separated, and the aqueous layer was acidified with cone. HCI to pH 4. This solution was twice extracted with ether. The extract was dried over MgSU4 and concentrated to give 4.6 g (96% yield) of 5-(3-methylphenyl)-2-thiophenecarboxylic acid. MS: 236 (M+NH 4 ) + . NMR (CDCI 3 ) d: 7.86 (d, 1 H, J=5 Hz), 7.5-7.4 (m, 2H), 7.35-7.10 (m, 3H), 2.4 (s, 3H). Following the procedures of Example 3, steps b-f and h, above, substituting the 5-(3-methylphenyl)-2-thiophenecarboxylic acid (prepared immediately above) for the 5-ethyl-2-thiophenecarboxylic acid of step 3b, the title compound was prepared, mp. 214-215°C. MS: 364 (M+H)+. NMR (CD3OD) δ: 7.6-7.4 (m, 2H), 7.32 (t, 1H, J=7 Hz), 7.16 (d, 1 H, J=7 Hz), 6.97 (s, 1H), 6.68 (s, 1 H), 4.56 (m, 2H), 4.10 (d, 1H, J=11 Hz), 3.3-3.2 (m, 1 H), 3.1 -2.8 (m, 2H), 2.40 (s, 3H), 2.4-2.2 (m, 1 H), 2.05-1.9 (m, 1 H). Anal. Calc'd for C22H22BrNO S » 0.2 HBr: C, 57.37; H, 4.86; N, 3.04; Found: C, 57.16; H, 4.89; N, 3.05; Comparative Example 46 2-(4-Methvlphenyn-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza- cvclopenta[c]phenanthrene-9.10-diol hvdrobromide Following the procedures as described in Example 45 above, substituting 4- bromotoluene for the 3-bromotoluene thereof, the title compound was prepared, mp 225-226°C. MS: 364(M+H)+. NMR (CD3OD) δ: 7.58 (d, 2H, J=8 Hz), 7.52 (s, 1 H), 7.25 (d, 2H, J=8 Hz), 6.97 (s, 1 H), 6.68 (s, 1 H), 4.55 (m, 2H), 4.10 (d, 1 H, J=11 Hz), 3.25-3.20 (m, 1 H), 3.1-2.8 (m, 2H), 2.38 (s, 3H), 2.4-2.2 (m, 1 H), 2.03-1.9 (m, 1H). Anal. Calc'd for C22H22BrN0 2 SO.3 HBr: C, 56.38; H, 4.80; N, 2.99; Found: C, 56.60; H, 4.77; N, 2.98; Comparative Example 47 2-(Adamantvn-4.5.5a.6.7.11 b-hexahvdro-3-thia-5-aza-cvclopenta[c]phenanthrene- 9.10-diol hvdrobromide Following the procedures as. described in Example 6 above, substituting 1- chloroadamantane for the t-butyl bromide of step 6a thereof, the title compound was prepared, mp 237-238°C. MS: 408 (M+H)+. NMR (CD3OD) δ: 6.99 (s, 1H), 6.88 (s, 1 H), 6.68 (s, 1 H), 4.46 (s, 2H), 4.05 (d, 1 H, J=11 Hz), 3.28-3.15 (m, 1 H), 3.05-2.8 (m, 2H), 2.42-2.30 (m, 1 H), 2.2-1.75 (m, 16H). Anal. Calc'd for C 2 5H3θBrN0 2 S*0.3 HBr: C, 58.88; H, 5.94; N, 2.69; Found: C, 58.56; H, 5.95; N, 2.73; Example 48 -f/ans-9.10-Diacetvloxv-2-DiODvl-4.5.5a.6.7.11 b-hexahvdro-3-thia-S-aya- cyclopenta[c]phenanthrene hydrochloride A suspension of (-)-fraπs-2-propyl-4,5,5a,6,7,11 -hexahydro-3-thia-5-aza- cyclopenta[c]phenanthrene-9,10-diol hydrobromide (the compound of Example 20) (50.6 mmol) in TFA (170 mL) was treated with acetyl chloride (16.2 mL, 228 mmol) resulting in a clear solution. The reaction was stirred at room temperature for 3 hr, then concentrated in vacuo. The crude product was partitioned between chloroform (700 mL) and sat. aq NaHCO3 (300 mL). The organic layer was washed with aq. NaHCOβ (250 mL), brine (250 mL), dried over sodium sulfate and concentrated to give 28.1 g of a tan foamy solid (theor. yield 20.2g). The compound was then treated with ethereal HCI, resulting in a white precipitate which was collected via vacuum filtration, mp. 234-237°C. MS: 400 (M + H)+. NMR (DMSO-D6) δ: 7.19 (s, 2H), 6.99 (s, 1 H), 4.47 (d, J = 15Hz. 1 H), 4.35 (d, J = 15Hz. 1 H), 4.16 (d, J = 11 Hz. 1 H), 3.30-3.20 (m, 1 H), 3.0-2.90 (m,2H), 2.86-2.75 (m,2H), 2.28 (s, 3H), 2.26 (s, 3H), 2.40-2.25 (m, 1 H), 2.05-1.90 (m,1 H), 1.65 (sextet, J = 8Hz, 2H), 0.95 (t, J = 8 Hz, 3H). Anal. calc. for C22H26CINO4S: C, 60.61 ; H, 6.01 ; N, 3.21 ; Found: C, 60.55; H, 6.04; N, 3.18. [a]D = -228° (c=1.25, methanol). Competitive Binding D-1 and D-2 Receptor Binding Assays Homogenized rat caudate was incubated in the presence of [ 125 I]SCH- 23982 (a selective antagonist of the dopamine D-1 receptor) and the compounds of this invention, according to procedures described by A. Sidhu, et al. in European J. Pharmacology. 113: 437 (1985) and in European J. Pharmacology. 128: 213 (1986). The compounds compete with the radiolabeled ligand for occupancy of the receptors and the molar potency of each compound was quantified. The affinity of the compound for the receptor (Ki) was calculated as described by Y.C. Cheng and W.H. Prusoff in Biochemical Pharmacology, 22:. 3099 (1973) from the relationship Ki = ICso(1 +[L]/KQ) where IC50 is the concentration of test compound which produces a 50% inhibition in the specific binding of the radioligand, L; [L] is the concentration of radioligand; and KD is the affinity of the radioligand for the receptor. The procedure for the dopamine D-2 receptor binding assay was similar to that used for the D-1 receptor assay. Homogenized rat caudate was the source of 67 SUBSnTUTESHEET (RULE 26) the D-2 receptors. The tissue homogenate was incubated in the presence of [ 3 H]- spiroperidol (a selective antagonist of the dopamine D-2 receptor) and the compounds being evaluated, according to the protocol described by T. Agui, N. Amlaiky, M.G. Caron and J.W. Kebabian in Molecular Pharmacology. 3,3: 163 (1988). The molar affinity of the compound for the receptor binding site was calculated by the same method used for the D-1 receptor assay, assuming a competitive interaction between the compound and the radiolabeled ligand. The competitive binding data (Ki values) from the D-1 and D-2 receptor binding assays are shown in Table 1. The Ki values are inversely proportional to the affinity of the compound for the receptor. Intrinsic Activity The interaction of dopamine or a dopamine D-1 receptor agonist with the D-1 receptor causes a dose-dependent increase in the adenylate cyclase- catalyzed conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP). The functional activity of the compounds of the invention was determined by assaying, in vitro, their ability to either stimulate the enzyme adenylate cyclase to produce more cAMP (agonist activity) or to antagonize a dopamine-induced increase in cAMP levels. The protocol for the adenylate cyclase assays was described by K.J. Watling and J.E.Dowling in J, Neurochemistrv, j36: 559 (1981) and by J.W. Kebabian, et al. in Proc Natl Acad Sci. USA, , 69: 2145 (1972). In order to determine agonist activity, cell-free tissue homogenates are incubated in an ionic buffer solution containing ATP and the compound being evaluated. The tissue was obtained from either goldfish retina or rat striatum. Table 2 shows the intrinsic activity in an adenylate cyclase assay indicating that the compounds of the present invention are dopamine agonists at the Di receptor. Rotation Behavior The behavioral assay used was based on the rat rotational model. Striatal dopamine was depleted by the intracranial injection of 6-hydroxydopamine, a neurotoxin which specifically destroys catecholaminergic neurons. The intracranial injection was conducted on anesthetized animals using standard stereotaxic techniques (U. Ungerstedt and G.W. Arbuthnott, Brain Research, 24: 485, 1970, and U. Ungerstedt, Acta Phvsiol. Scand. SUDDI. 367. 69: 1973). This unilateral lesioning of dopamine-containing neurons causes the post synaptic dopamine receptors to become supersensitive to dopaminergic stimulation in behavioral assays. When these striatal dopamine receptors are stimulated by the test compounds, the rats rotate or physically turn, in a direction that is away from the side of their body that receives the greater dopaminergic activation due to the receptor supersensitivity. Agonist activity was measured by the ability of the test compound to induce rotation. Table 3 shows the rotation behavior of selected compounds of the present invention. Table 3 Rotation Behavior

Claims: What is Claimed is: 1. A compound of the formula: or a pharmaceutically-acceptable salt, ester or carbamate thereof, wherein: R 1 is hydrogen or a readily-cleavable group, as defined below; A and the atoms to which it is attached are selected from the group consisting of: wherein: X is sulfur or oxygen; R 2 is hydrogen, Cl, CF 3 , Cι-C6-alkyl, C 3 -C7-cycloalkyl, -CH 2 -C 3 -C5-cycloalkyl, phenyl or thiophene; R 3 is hydrogen, or when R 2 is hydrogen, Cl, C Cβ-alkyl or CF3, additionally is Cl, Ci-Cs-alkyl or CF 3 ; and R 4 is hydrogen, Cl, Ci-Cβ-alkyI, or C 3 -C7-cycloalkyl. 2. A compound according to Claim 1 , wherein A and the atoms to which it is attached are selected from the ring systems: 3. A compound according to Claim 1 , wherein A and the atoms to which it is attached are selected from the ring systems: 4. A compound according to Claim 3, wherein A and the atoms to which it is attached are: 3b 5. A compound according to Claim 1 , which is: frat7s-2-Methyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-4,5,5a,6,7,11 b-Hexahydro-2-thia-5-aza-cyclopenta[c]-phenanthrene-9,10- diol; fra/is-2-Ethyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frans-2-Ethyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frans-2-Propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; trans-2-(\ ,1 -Dimethylethyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; fraπs-2-(2-Propyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; /rans-2-Butyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; fra/7s-2-(2-Butyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-(2,2-Dimethylpropyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza- cyclopenta[c]-phenanthrene-9,10-diol; frat7s-2-Cyclohexyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-2-Phenyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frans-2-(1 ,1 -Dimethylethyl)-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-2-Ethyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; fraπs-2-Propyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; fraπs-2-Butyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Cyclohexyl-4,5,5a,6,7,11 b-hexahydro-1-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-4,5,5a,6,7,11 b-Hexahydro-1 -thia-5-aza-cyclopenta[c]-phenanthrene-9,10- diol; frat7s-2-Phenyl-4,5,5a,6,7,11b-hexahydro-1-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-fraπs-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2,3-Dimethyl-4,5,5a,6,7,1 1 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-2-Methyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-fraπs-2-Methyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frat7s-2-(1 ,1-Dimethylethyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza- cyclopenta[c]-phenanthrene-9,10-diol; ?raπs-4,5,5a,6,7,11 b-Hexahydro-3-thia-5-aza-cyclopenta[c]-phenanthrene-9,10- diol; frat7s-2-Trifluoromethyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Propyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-3,5-diaza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-1 ,5-diaza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Propyl-4,5,5a,6,7,11 b-hexahydro-1-oxa-3,5-diaza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-(3-Methylbutyl)-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Hexyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Chloro-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; rans-2-(1 -Cyclopentylmethyl)-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza- cyclopenta[c]-phenanthrene-9,10-diol; frat7s-2-lsopropyl-4,5,5a,6,7,11 b-hexahydro-1 -thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-(3-Methylbutyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; fraπs-2-Pentyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-(2-Thiophenyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; fraπs-2-Hexyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frans-2-(Cyclopentylmethyl)-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza- cyclopenta[c]-phenanthrene-9,10-diol; frans-2-Ethyl-4,5,5a,6,7,1 1 b-hexahydro-3-oxa-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; fraπs-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-oxa-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Phenyl-4,5,5a,6,7,11 b-hexahydro-3-oxa-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-3-Propyl-4,5,5a,6,7,11 b-hexahydro-2-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; or (-)-frat7s-9,10-Diacetyloxy-2-propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza- cyclopenta[c]phenanthrene. 6. A compound according to Claim 5, which is: fraπs-2-Ethyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frat7s-2-Ethyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; trans-2-(1 ,1 -Dimethylethyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Butyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frat7s-2-Propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; 77 SUBSTITUTE SHEET (RULE 26} trat7s-2-Methyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-trans-2-Methyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frat7S-2-(1 ,1-Dimethylethyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza- cyclopenta[c]-phenanthrene-9,10-diol; frat7s-2-Propyl-4,5,5a,6,7,11 b-hexahydro-1 -oxa-3,5-diaza-cyclopenta[c]- phenanthrene-9,10-diol; frat7S-2-Ethyl-4,5,5a,6,7,11 b-hexahydro-3-oxa-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-oxa-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; or (-)-fraπs-9,10-Diacetyloxy-2-propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza- cyclopenta[c]phenanthrene. 7. A compound according to Claim 6, which is: rrans-2-Ethyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frans-2-Ethyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; fraπs-2-Propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-(1 ,1 -Dimethylethyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; frat7s-2-Butyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frat7s-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; fra/7s-2-Methyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frat7s-2-Methyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; (-)-frat7s-2-(1 ,1 -Dimethylethyl)-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza- cyclopenta[c]-phenanthrene-9,10-diol; or (-)-fraπs-9,10-Diacetyloxy-2-propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza- cyclopenta[c]phenanthrene. 8. A compound according to Claim 7, which is: (-)-frat7s-2-Propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza-cyclopenta[c]- phenanthrene-9,10-diol; or (-)-frans-9,10-Diacetyloxy-2-propyl-4,5,5a,6,7,11 b-hexahydro-3-thia-5-aza- cyclopenta[c]phenanthrene. 9. A pharmaceutical composition for selectively binding and activating dopaminergic receptors comprising a pharmaceutically-acceptable carrier and a therapeutically-effective amount of a compound according to Claim 1. 10. A pharmaceutical composition for treating dopamine-related neurological, psychological, cardiovascular, cognitive or attention disorders or substance abuse or addictive behavior, or a combination of these indications, comprising a pharmaceutically-acceptable carrier and a therapeutically-effective amount of a compound of Claim 5. 11. A method for treating dopamine-related neurological, psychological, cardiovascular, cognitive or attention disorders, substance abuse or addictive behavior, or a combination of these indications, characterized by abnormal dopaminergic activity comprising administering to a patient in need of such treatment a therapeutically-acceptable amount of a compound according to Claim 1.

Inventors: HONG YUFENG, MICHAELIDES MICHAEL R, HONG, YUFENG, MICHAELIDES, MICHAEL, R.
Applicants: ABBOTT LAB, ABBOTT LABORATORIES
Application year: 1994
Main classification: C07D471
IPC codes: A61K31, A61P1, A61P9, A61P25, A61P39, C07D491, C07D495, C07D498, C07D513