INHIBITORS OF HIV REVERSE TRANSCRIPTASE

Abstract: Novel indole compounds inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

Description: TITLE OF THE INVENTION INHIBITORS OF HIV REVERSE TRANSCRIPTASE This application is a continuation-in-part of co-pending application U.S. Serial No. 07/866,765 filed April 9, 1992, which itself is a continuation-in-part of application U.S. Serial No. 07/832,260 filed February 7, 1992 and now abandoned, which itself was a continuation- in-part of application U.S. Serial No. 07/756,013, filed September 6, 1991, now abandoned. The present invention is concerned with compounds which inhibit the reverse transcriptase encoded by human immunodeficiency virus (HTV) or pharmaceutically acceptable salts thereof and are of value in the prevention of infection by HTV, the treatment of infection by HTV and the treatment of the resulting acquired immune deficiency syndrome (AIDS). It also relates to pharmaceutical compositions containing the compounds and to a method of use of the present compounds and other agents for the treatment of AIDS and viral infection by HTV. BACKGROUND OF THE INVENTION A retroviras designated human immunodeficiency virus (HIV) is the etiological agent of the complex disease that includes progressive destruction of the immune system (acquired immune deficiency syndrome; AIDS) and degeneration of the central and peripheral nervous system. This vims was previously known as LAV, HTLV-iπ, or ARV. A common feature of retrovirus replication is reverse transcription of the RNA genome by a virally encoded reverse transcriptase to generate DNA copies of HTV sequences, a required step in viral replication. It is known that some compounds are reverse transcriptase inhibitors and are effective agents in the treatment of AIDS and similar diseases, e.g., azidothymidine or AZT. Nucleotide sequencing of HIV shows the presence of a . gene in one open reading frame [Ratner, L. et al., Nature, 313. 277(1985)]. Amino acid sequence homology provides evidence that the pol sequence encodes reverse transcriptase, an endonuclease and an HTV protease [Toh, H. et aL, EMBO J. 4, 1267 (1985); Power, M.D. et aL, Science, 231, 1567 (1986); Pearl, L.H. et al., Nature 222, 351 (1987)]. The compounds of this invention are inhibitors of HTV reverse transcriptase. Furthermore, the compounds of the present invention do not require bioactivation to be effective. BRIEF DESCRIPTION OF THE INVENTION Novel compounds of formula A: as herein defined, are disclosed. These compounds are useful in the inhibition of HTV reverse transcriptase, the prevention of infection by HTV, the treatment of infection by HIV and in the treatment of AIDS and/or ARC, either as compounds, pharmaceutically acceptable salts (when appropriate), pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating ADDS, methods of preventing infection by HTV, and methods of treating infection by HIV are also disclosed. DETAILED DESCRIPTION OF THE INVENTION AND PREFERRED EMBODIMENTS This invention is concerned with the compounds of formula A described below, combinations thereof, or pharmaceutically acceptable salts or esters thereof, in the inhibition of HTV reverse transcriptase, the prevention or treatment of infection by HIV and in the treatment of the resulting acquired immune deficiency syndrome (AIDS). The compounds of this invention include those with structural formula A: wherein W is O, S, -N-CN, or -N-OR2, 2) -CORla, 3) -COORlb, 4) -CR2R2-S(0) n -Rla, wherein n is defined above, 5) -CR2R2NHR4, 6) -CR2R2-CO-R5, 7) -Cι_3alkyl substituted with one or more of: a) aryl, unsubstituted or substituted with one or more of: i) -Cι_ 5 alkyl, ii) -Cι_5alkoxy, iii) -OH, iv) halogen, or v) -NR2R2, or b) heterocycle, unsubstituted or substituted with one or more of: - " 0 5 0 5 0 a) -Cι_5alkoxy, b) -OH, c) aryl, unsubstituted or substituted with one or more of: i) -Ci- 5 alkyl, ii) -Cι_5alkoxy, iii) -OH, ' iv) halogen, or v) -NR2R2, or d) heterocycle, unsubstituted or substituted with one or more of: i) -Cι_ 5 alkyl, ii) -Ci-5alkoxy, 0 iii) -OH, iv) halogen, or v) -NR2R2, 2) aryl, unsubstituted or substituted with one or more of: 5 a) -Ci -5alkyl, unsubstituted or substituted with one or more of: i) -OH or ii) -Cι _5alkoxy, b) -Cι_5alkoxy, c) -OH, d) halogen, e) -CN, f) -Nθ2, or g) -NR2R2; or 5 3) heterocycle, unsubstituted or substituted with one or more of: a) -Cι_5alkyl, unsubstituted or substituted with one or more of: i) -OH or ii) -Cj_5alkoxy, b) -Cι_5alkoxy, c) -OH, d) halogen, or e) -NR2R2; R2 is hydrogen or C1.3a._kyl; i) -C3_6cycloalkyl, 4) heterocycle, unsubstituted or substituted with one or more of: i) -Cι_ 5 alkyl, ii) -C _5alkoxy, iii) -OH, iv) halogen, or v) -NR2R2 ; R6 IS 1 ) hydrogen, 2) -COR , 3) -CONHRl; R7 is 1) aryl, unsubstituted or substituted with one or more of -Cl, -Br, -OH, -OCH3, or -CN, or 2) -Ci-5alkyl, unsubstituted or substituted with one or more of -OH or -NR2R2 ; and with the proviso that when X is -H, Y is -S, R is unsubstituted phenyl and R 6 is -H, Z is not -CH2-SO-Ph, -COH, or a pharmaceutically acceptable salt or ester thereof. One embodiment of this invention encompasses compounds of Formula A further limited to: X is -H, -Cl or -F; Y is -S(0)n-; R is -Ph, -tolyl, 3-Cl-phenyl, 2-pyridyl or 2-thiazolyl; R6 is -H; and Z is ■ -C _3alkyl substituted with heterocycle. One class of compounds within the first embodiment is further limited to compounds wherein X is -H or -Cl; Y is -S(0)n-; R is -Ph, -tolyl, 3-Cl-phenyl or 2-thiazolyl; R 6 is -H; and Z is wherein R2 is -H and W is -O, -S or -NCN, or 2) -CR2R2-SO-aryl, wherein the aryl group is unsubstituted or substituted with one or more of Cι_ 5 alkyL A sub-class of compounds within this class is further limited to compounds wherein X is -Cl; Y is -S(0)n-; n is 1 or 2; R is -Ph, 3-Cl-phenyl or 2-thiazolyl; R6 is -H; Z is -C-NR 2 R 3 f W , wherein R 2 is -H, and W is -O, -S or -NCN; and A second embodiment of this invention encompasses compounds of formula A wherein X is selected from the group consisting of: 1) -NR2R2, 2) -NHS02-Cι_3alkyl, and 3) -NHCO-Cι_3alkyl. A third embodiment of this invention encompasses compounds of formula A wherein Z is and R3 is selected from the group consisting of: 1 ) C -3alkyl substituted with phenyl wherein phenyl is substituted with one or more of: a) -N0 2 , b) -NR2R2, c) -NHCO-Cι_3alkyl or d) -NHS02-Cι_3alkyl, and 2) Ci-3alkyl substituted with heterocycle, wherein heterocycle is substituted with one or more of: a) halogen, b) oxo, c) -N0 2 , d) -NR2R2, e) -NHCO-Cι_3alkyl, or f) -NHS02-Cι_3alkyl. A fourth embodiment of this invention encompasses compounds of formula A wherein Y is -S(0) n - and R is -NR2R3. The most preferred compounds of this invention are compounds 1 through 39, shown below. Compound 1: N-ethyl-5-chloro-3-phenylthioindole-2-carboxamide Compound 2: N-2-hydroxyethy 1-5 -chloro-3 -phenylthioindole-2-carboxamide Compound 3: N-2-methoxyethyl-5-chloro-3-phenylthioindole-2-carboxamide Compound 4: 10 N-3-methoxybenzyl-5-chloro-3-phenylthioindole-2-carboxamide Compound 5: N-4-pyridylmethyl-5-chloro-3-phenylthioindole-2-carboxamide 0 Compound 6: N-3-pyridylmethyl-5-chloro-3-phenylthioindole-2-carboxamide 0 Compound 7: N-2-furanylmethyl-5-chloro-3-phenylthioindole-2-carboxamide Compound 8: N-3-pyridyl-5-chloro-3-phenylthioindole-2-carboxamide Compound 9: N-[ 1 -(2(R)-hydroxypropyl)]-5-chloro-3-phenyl-thioindole-2- carboxamide Compound 10: N-(2-pyridyl)methyl-5-chloro-3-phenylthioindole-2-carboxamide Compound 11 : N-(3-methoxy-4-pyridyl)methyl-5-chloro-3-phenylthioindole-2- carboxamide Compound 12: N-(3-hydroxymethyl)benzyl-5-chloro-3-phenylthioindole-2- carboxamide Compound 13: 5-chloro-3-phenylthioindole-2-carboxamide Compound 14: N-(3-hydroxybenzyl)-5-chloro-3-phenylthioindole-2-carboxamide Compound 15: N-2-furanylmemyl-5-chloro-3-phenyltWoindole-2-thiocarboxamide Compound 16: 5-chloro-3-phenylthioindole-2-thiocarboxamide Compound 17: 5-chloro-3-phenylsulfinylindole-2-carboxamide Compound 18: 5-chloro-3-phenylsulfonylindole-2-carboxamide. Compound 19: N-[(l-methylιmιdazol-2-yl)methyl]-3-phenylsulfonyl-5- chloroindole-2-carboxamide Compound 20: N-[(l-methylimidazol-2-yl)methyl]-3-phenylsulfinyl-5-chloroindole-2- carboxamide Compound 21: N- [( 1 -methy limidazol-4-yl)methyl] -3 -pheny lsulf onyl-5 • chloroindole-2-carboxamide N-[(l-methylimidazol-5-yl)methyl]-3-phenylsulfonyl-5- chloroindole-2-carboxamide Compound 23: N-[(l-methylimidazol-2-yl)methyl]-3-(3-chlorophenyl-sulfonyl)-5- chloroindole-2-carboxamide Compound 24: N-[2-(imidazol-4-yl)ethyl]-3-phenylsulfonyl-5-chloroindole-2- carboxamide Compound 25: N-[2-(l-methylimidazol-4-yl)ethyl]-3-phenylsulfonyl-5-chloroindole-2- carboxamide Compound 26: N-cyclopropyl-5-chloro-3-phenylsulfonylindole-2-carboxamide Compound 27: N-cyclobutyl-5-chloro-3-phenylsulfonylindole-2-carboxamide Compound 28: N-(3-pyridylmethyl)-3-phenylsulfonyl-5-chloroindole-2-carboxamide Compound 29: N-(4-pyridylmethyl)-5-chloro-3-phenylsulfinylindole-2-carboxamide Compound 30: N-(3-aminobenzyl)-3-phenylsulfonyl-5-chloroindole-2-carboxamide Compound 31: N-(3-methoxybenzyl)-5-chloro-3-(2-thiazolyl)sulfonyl-indole-2- carboxamide Compound 32: N-[(S)-l-phenyl-2-hydroxyethyl]-5-chloro-3-phenylsulfonylindole-2- carboxamide Compound 33: N-[(R)-1 -pheny lethyl]-5-chloro-3-phenylsulfonylindole-2-carboxamide Compound 34: N-(3-methylsulfonylaminobenzyl)-3-phenylsulfonyl-5-chloroindole-2- carboxamide Compound 35: N-cyano-5-chloro-3-phenylsulfonylindole-2-carboximid-amide Compound 36: 3-phenylsulfonyl-5-methylsulfonylaminoindole-2-carboxamide Compound 37: 4-[(5-chloro-3-phenylsulfonylindole-2-carboxamido)-methyl]pyridin- 2(lH)-one Compound 38: N-(2-amino-4-pyridylmethyl)-5-chloro-3-phenylsulfonyl-indole-2- carboxamide, and Compound 39: N-cyclopropyl-5-chloro-3-phenylsulfinylindole-2-carboxamide. The compounds of the present invention may have asymmetric centers and occur as racemates, racemic mixtures, individual diastereomers, or enantiomers, with all isomeric forms being included in the present invention. When any variable (e.g., aryl, heterocycle, Rl, R2, R3 5 etc.) occurs more than one time in any constituent or in formula A of this invention, its definition on each occurrence is independent of its definition at every other occurrence. Also, combinations of substituents and/or variables are permissible only if such combinations result in stable compounds. As used herein except where noted, "alkyl" is intended to include both branched- and straight-chain saturated aliphatic hydrocarbon groups having the specified number of carbon atoms; "alkoxy" represents an alkyl group of indicated number of carbon atoms attached through an oxygen bridge. "Halogen" or "halo" as used herein, means fluoro, chloro, bromo and iodo. As used herein, with exceptions as noted, "aryl" is intended to mean any stable monocyclic, bicyclic or tricyclic carbon ring of up to 7 members in each ring, wherein at least one ring is aromatic. Examples of such aryl elements include phenyl, naphthyl, tetrahydro- naphthyl, biphenyl. The term heterocycle or heterocyclic, as used herein except where noted, represents a stable 5- to 7-membered monocyclic or stable 8- to 11-membered bicyclic heterocyclic ring which is either saturated or unsaturated, and which consists of carbon atoms and from one to three heteroatoms selected from the group consisting of N, O and S, and wherein the nitrogen and sulfur heteroatoms may optionally be oxidized, and the nitrogen heteroatom may optionally be quaternized, and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring. The heterocyclic ring may be attached at any heteroatom or carbon atom which results in the creation of a stable structure. Examples of such heterocyclic elements include piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2- oxopyrrolidinyl, 2-oxoazepinyl, azepinyl, pyrrolyl, 4-piperidonyl, pyrrolidinyl, pyrazolyl, pyrazolidinyl, imidazolyl, imidazolinyl, imidazolidinyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, oxazolyl, oxazolidinyl, isoxazolyl, isoxazolidinyl, morpholinyl, thiazolyl, thiazolidinyl, isothiazolyl, quinuclidinyl, isothiazolidinyl, indolyl, quinolinyl, isoquinolinyl, benzimidazolyl, thiadiazoyl, benzopyranyl, benzothiazolyl, benzoxazolyl, furyl, tetrahydrofuryl, benzofuranyl, tetrahydropyranyl, thienyl, benzothienyl, thiamorpholinyl, thiamo holinyl sulfoxide, thiamorpholinyl sulfone, and oxadiazolyl. Further abbreviations that may appear in this application are as follows: BOP-reagent benzotriazol- 1 -yloxytris-(dimethyl- amino)phosphonium hexafluorophosphate mp or m.p. melting point The pharmaceutically-acceptable salts of the novel compounds of this invention that are capable of salt formation (in the form of water- or oil- soluble or dispersible products) include the conventional non-toxic salts or the quaternary ammonium salts of these compounds, which are formed, e.g., from inorganic or organic acids or bases. Examples of such acid addition salts include acetate, adipate, alginate, aspartate, benzoate, benzenesulfonate, bissulfate, butyrate, citrate, camphorate, camphorsulfonate, cyclopentanepropionate, digluconate, dodecylsulfate, ethanesulfonate, fumarate, glucoheptanoate, glycerophosphate, hemisulfate, heptanoate, hexanoate, hydrochloride, hydrobromide, hydroiodide, 2-hydroxyethanesulfonate, lactate, maleate, methanesulfonate, 2-naphthalenesulfonate, nicotinate, oxalate, pamoate, pectinate, persulfate, 3-phenylpropionate, picrate, pivalate, propionate, succinate, tartrate, thiocyanate, tosylate, and undecanoate. Also, the basic nitrogen-containing groups may be quatemized with such agents as lower alkyl halides, such as methyl, ethyl, propyl, and butyl chloride, bromides and iodides; dialkyl sulfates like dimethyl, diethyl, dibutyl; and diamyl sulfates, long chain halides such as decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides, aralkyl halides like benzyl and phenethyl bromides and others. Esters are also encompassed by the present invention, and include those which would readily occur to the skilled artisan, for example, Cl-4 alkyl esters. Schemes I-VIQ for preparing the novel compounds of this invention are presented below. Tables I - VII which follow the schemes illustrate the compounds that can be synthesized by Schemes I-VUI, but Schemes I - VTJI are not limited by the compounds in the tables nor by any particular substituents employed in the schemes for illustrative purposes. The examples specifically illustrate the application of the following schemes to specific compounds. Scheme I, below, is a general route for synthesizing, e.g., the compounds shown in Table I, infra. The substituent groups (e.g., X, R, Rl, etc.) employed in Scheme I correspond to the substituent groups as defined in Table I, but Scheme I is not limited by the defined substituents or compounds of Table I. SCHEME I li 1) (CO) 2 CI 2 , CHCI 3 , Δ BOP-reagent, or R 2 R 3 NH, DMF As shown in Scheme I, commercially available indole-2- carboxylic acid (or 5-chloro, 5-fluoro or 5-methoxyindole-2-carboxylic acid) I is treated with an excess of sodium hydride in dimethyl- formamide in the presence of an aryl disulfide such as phenyldisulfide at 0°C to 60°C, according to the general procedure described by Atkinson, et aL, in Synthesis, p. 480-481 (1988). The resulting product II is reacted with oxalyl chloride in refluxing chloroform for about 30 minutes to 1 hour to produce the corresponding acid chloride which is then reacted with a primary or secondary amine in chloroform at 0°C to 20°C to give the amide in. Alternatively, amide in can be produced directly from H by treatment with BOP reagent (benzotriazol-1- yloxytris-(dimethylamino)-phosphonium hexafluorophosphate) in the presence of the desired primary or secondary amine and triethylamine, in a solvent such as dimethyl-formamide. Other carboxyl group activating reagents such as l,l'-carbonyl-diimidazole can also be used for this step. Saponification of ethyl 5-chloro-3-benzylindole-2- carboxylate (prepared as described below) by methods familiar to those skilled in the art, yields 5-chloro-3-benzylindole-2-carboxylic acid, which can be converted to the desired amides in the manner described for the synthesis of amides m. The compounds shown in Table infra, are generally synthesized as in Scheme I, except R OH is used in place of R2R3NH, as depicted in Scheme H below. The substituent groups employed in Scheme II correspond to the substituent groups as defined in Table π, but Scheme II is not limited by the defined substituents or compounds of Table π. SCHEME Π 11 IV IS As shown in Scheme H, 3-phenylthioindole-2-carboxylic acid π can be converted to the corresponding acid chloride with oxalyl chloride in refluxing chloroform, and reacted with an alcohol to give the ester IV. In an altemative procedure, la may be converted to IV by reaction with N-phenylmio-succinimide in chloroform at room temperature with a Lewis acid, such as boron trifluoride etherate, as catalyst (as shown in Scheme π). The compound ethyl 5-chloro-3- benzylindole-2-carboxylate was prepared according to the procedure described by Inaba, et aL, in Chem. Pharm. Bull., 2ft, p. 1076-1082 (1976). Scheme IE, below, is a general route for synthesizing, e.g., the compounds shown in Table ED, infra. The substituent groups employed in Scheme HI correspond to the substituent groups as defined in Table HI, but Scheme m is not limited by the defined substituents or compounds of Table HI. SCHEME m m χ R χ is H or CH 3 ) MMPP CH 3 OH-CHCI 3 IX As shown in Scheme HI, commercially available ethyl indole-2-carboxylate (compound V wherein X is -H) or ethyl 5- chloroindole-2-carboxylate (compound V wherein X is -Cl), was reduced to the primary alcohol VI with an excess of lithium aluminum hydride in tetrahydrofuran at 0°C. Compound VI was converted to the sulfide VII by treatment with an excess of tri-n-butylphosphine and an aryldisulfide such as phenyl-disulfide in tetrahydrofuran at 0°C to 20°C for 6-24 hours. Reaction of sulfide VII with sodium hydride, an aryldisulfide such as phenyldisulfide, in dimethylformamide at 0°C to 20°C for 1 to 18 hours produces bis-sulfide VIE. Aryl disulfides which were not commercially available were obtained by oxidation of the commercially available aryl mercaptan with dimethyl sulfoxide and iodine, according to the procedure described by Orville G. Lowe in J. Org. Chem.. 40, p. 2096-2098 (1975). Compound VIE can be N- alkylated, if desired, by methods familiar to those trained in the art, e.g., by treatment with sodium hydride in dimethylformamide at 0°C in the presence of an alkylating agent such as iodomethane, to give compound DC. Thereafter, compound VIE (or DC) is treated with one equivalent of peracid such as monoperoxyphthahc acid, magnesium salt (MMPP), or meta-chloroperoxy-benzoic acid in methanol or chloroform-methanol at 0°C for 30 minutes to 3 hours, to give predominately sulfoxide X. Schemes IV-A and IV-B , below, show a general route for synthesizing, e.g., the compounds shown in Tables IV-A and IV-B, infra. The substituent groups employed in Schemes IV-A and IV-B, respectively, correspond to the substituent groups as defined in Tables IV-A and IV-B, respectively, but Schemes IV-A and IV-B are not limited by the defined substituents or compounds of Tables IV-A and ΓV-B. SCHEME ΓV-A XI m SCHEME IV-B MA XIII As shown in Scheme IV-A, 3-phenylthioindole- 2-carboxamides XI can be reduced to primary or secondary amines XE by reaction with an excess of borane-dimethylsulfide complex in refluxing tetrahydrofuran for 6-24 hours. As shown in Scheme IV-B, the primary amine XE-A can be acylated with an acid chloride, such as benzoyl chloride, in chloroform in the presence of pyridine, to give the amide XIE. Scheme V, below, is a general route for synthesizing, e.g., the compounds shown in Table V-A and Table V-B, infra. The substituent groups employed in Scheme V correspond to the substituent groups as defined in Tables V-A and V-B, but Scheme V is not limited by the defined substituents or compounds of Tables V-A and V-B. SCHEMEV 1) n-BuLi 2) C0 2 1) t-Buϋ 2) R 1 -NCO/H + XVII As shown in Scheme V, commercially available 2-methyl- indole XTV can be treated with sodium hydride in dimethylformamide in the presence of an aryldisulfide such as phenyldisulfide to give compound XV. Compound XV can be converted to the monoanion with n-butyl-lithium in tetrahydrofuran at -78°C, and then reacted with carbon dioxide to give carboxylate XVI. The dianion formed by the reaction of XVI with t-butyllithium could be reacted with an isocyanate, such as phenyliso-cyanate, to give a mixture of monoacylated product and diacylated product XVE (see Table V-B). Alternatively, the dianion formed by the reaction of XVI with t-butyllithium could be reacted with an N-methoxy-N-methyl amide such as N-methoxy-N- methyl-furan-2-carboxamide (prepared in a manner familiar to those skilled in the art, e.g., by the methods described in Scheme 1) to produce ketones XVEI. The methodology described above is essentially that used by A. J. Katritsky and K. Akutagawa to prepare 2-indoleacetic acids, and is published in J. Am. Chem. Soc. 108. 6808 (1986). Scheme VI, below, is a general route for synthesizing, e.g., the compounds shown in Table VI, infra. The substituent groups employed in Scheme VI correspond to the substituent groups as defined in Table VI, but Scheme VI is not limited by the defined substituents or compounds of Table VI. SCHEME VI As shown in Scheme VI, N-methoxy-N-methyl-3-phenyl- thioindole-2-carboxamide XIX (or N-methoxy-N-methyl-5-chloro-3- phenylthioindole-2-carboxamide) (prepared as in Scheme 1) can be reacted with Grignard reagents (wherein Rl is not hydrogen) such as phenylmagnesium chloride, in tetrahyrodrofuran at -78°C to 20°C for 18-48 hours, or XIX can be reacted with other organometallic reagents well known in the art to one of ordinary skill, to produce ketones XX. The compounds shown in Table VE infra, can generally be synthesized by those of ordinary skill in the art according to methods described in Schemes I through VI, with the exception of 2-(2- benzoxazol-2-ylethyl)-3-phenylthioindole (compound XXTV), the synthesis of which is described below in Scheme VE. HO As shown in Scheme VE, N-methoxy-N-methyl-3- phenylthioindole-2-carboxamide XXI can be reduced to aldehyde XXE with lithium aluminum hydride in tetrahydrofuran at 0°C to 20°C for 2- 4 hours. Aldehyde XXE could be reacted with the hthium salt of [(benzoxal-2-yl)methyl]diethyl-phosphonate to produce olefin XXEI, which is then hydrogenated in the presence of 10% palladium on charcoal in methanol under one atmosphere of hydrogen to give compound XXIV. The compound 5-chloro-2-cyano-3-phenylthioindole in Table VE can be prepared by dehydro-sulfurization of 5-chloro-3- phenyl-thioindole-2-thiocarboxamide with, e.g., Hg(OAc)2- Using methods well-known to those skilled in the art, compounds of formula A where Y is -SO- or -S02- can be synthesized by treatment of compounds where Y is -S- with a suitable oxidizing agent such as, for example, meta-chloroperoxybenzoic acid (MCPBA), sodium periodate or hydrogen peroxide in an appropriate solvent such as MeOH, CHC13 or acetic acid, or potassium persulfate in a solvent such as MeOH/H2θ. Altemative routes to amide derivatives of formula A where Y = -SO- or -SO2- are shown in Scheme VIE. Intermediate acid E can be oxidized (with for example meta-chloroperoxybenzoic acid (MCPBA) in CHCI3) to the Y = -SO- or -SO2- acid derivative XXV which can then be converted to the corresponding amide derivatives XXVE employing the amide forming conditions indicated in Scheme I. In another useful sequence, intermediate ester IVa can be oxidized to the Y = -SO- or -SO2- ester intermediate XXVI which on reaction with ammonia or a primary amine with heating is converted to compounds of formula XXVE. SCHEMEVEI 25 30 TABLEI R S m.p. Cl S H CH 2 CH 2 CH 2 OH 215°C 5 0 Cl S H CH a 220-221 °C TABLE I. Cont'd m.p. Cl H CH 2 CH 2 CH 2 OCH 3 170-171 °C Cl H CH 2 CH 2 -N^N 256°C (HCI salt) Cl H CH(CH 3 ) 2 193-194°C Cl CH, Ph 191-192°C Cl H CH 2 CH 2 CH 2 N(CH 3 ) 2 229-230°C (HCI salt) TABLE I. Cont'd m.p. Cl H Ph 245-246°C Cl S H CH 2 CH 2 CH2-N O 162-164°C Cl S H CH 2 — Δ 219-219.5°C Cl S H CH 2 Ph 222°C Cl S H CH 2 -— (O( )>—- OCH 3 198°C Cl S H CH 2 CH 2 OCH 2 CH 2 OH 161.5-162.5°C TABLE I. Cont'd R 2 R 3 m.p. Cl H CH 2 CH OCH 3 216-217.5°C Cl H CH CH OC Hi 165.5-167°C Cl S H CH — e 182-183°C O Cl S H CH 2 CHCH 3 205°C OH TABLE I. Cont'd R* R 3 k p„ Cl H OCH, 179-180°C - Cl H • ?CH-CH 2 CH 3 153-154°C CH 2 OH O II Cl H CH 2 COC 2 H 5 215-215.2°C -CHCH 2 OCH 3 Cl S H ' 168-169°C CH 3 OH Cl S H — CHg^^ 202-203°C Cl S H -CH 2 CH 2 CH 2 -N / J I *HCI 188-189°C CH 2 OH TABLE I. Cont'd m.p. Cl H -H 213-215°C Cl SO; H H 255-257°C Cl SO ; H -CHH 249-251 °C TABLE I. Cont'd R m.p. Cl SO; H -CH 2 CH 2 0H 198-200°C Cl SO; H 211-215°C Cl SO; H ~ 149°C CHTJ, \- , TABLE I. Cont'd R' m.p. Cl SO; H -CH 2→ Q N 278-281 °C TABLE E )1b m.p. H Ph CH, 179-180°C 0CH< Ph CH, 211-212°C Cl Ph CH, 193-196°C Cl Ph CH Ph 154-155°C Cl CH; Ph C 2,H π 5 196-197°C Ph C 2oH n 5 149°C TABLE IE m.p. H Ph Ph H 71-74°C H Ph Ph H H Ph Ph H 168-169°C 0CH 3 Ph Ph 1 H 70-80°C H Ph Ph 0 CH 3 98-99°C TABLE IE. Cont'd >1a m.p. H Ph Ph CH, 177-178°C H Ph CH, H 164-168°C H Ph H TABLE El. Cont'd Cl Ph Ph 1 H 158-162°C TABLE IV-A m.p. 10 15 25 »1 m.p. -CH 3 -Ph 64-65°C 30 TABLE V-A R £ m.p. TABLE V-B m.p. H -Ph H 66-68°C TABLE VI )1a m.p. TABLE VE The compounds of the present invention are useful in the inhibition of HTV reverse transcriptase, the prevention or treatment of infection by the human immunodeficiency virus (HIV) and the treatment of consequent pathological conditions such as ADDS. Treating AIDS or preventing or treating infection by HTV is defined as including, but not limited to, treating a wide range of states of HTV infection: AIDS, ARC (AIDS related complex), both symptomatic and asymptomatic, and actual or potential exposure to HIV. For example, the compounds of this invention are useful in treating infection by HTV after suspected past exposure to HTV by, e.g., blood transfusion, organ transplant, exchange of body fluids, bites, accidental needle stick, or exposure to patient blood during surgery. The compounds of this invention are also useful in the preparation and execution of screening for antiviral compounds. For example, the compounds of this invention are useful for isolating enzyme mutants, which are excellent screening tools for more powerful antiviral compounds. Furthermore, the compounds of this invention are useful in establishing or determining the binding site of other antivirals to HTV reverse transcriptase e.g., by competitive inhibition. Thus the compounds of this invention are commercial products to be sold for these purposes. For inhibition of HIV reverse transcriptase, the prevention or treatment of infection by HIV and the treatment of AIDS or ARC, the compounds of the present invention may be administered orally, parenterally (including subcutaneous injections, intravenous, intramuscular, intrastemal injection or infusion techniques), by inhalation spray, or rectally, in dosage unit formulations containing conventional non-toxic pharmaceutically-acceptable carriers, adjuvants and vehicles. Thus, in accordance with the present invention there is further provided a method of treating and a pharmaceutical composition for treating HTV infection and AIDS. The treatment involves administering to a patient in need of such treatment a pharmaceutical composition comprising a pharmaceutical carrier and a therapeutically- effective amount of a compound of the present invention. These pharmaceutical compositions may be in the form of orally-administrable suspensions or tablets; nasal sprays; sterile injectable preparations, for example, as sterile injectable aqueous or oleagenous suspensions or suppositories. When administered orally as a suspension, these compositions are prepared according to techniques well-known in the art of pharmaceutical formulation and may contain microcrystalline cellulose for imparting bulk, alginic acid or sodium alginate as a suspending agent, methylcellulose as a viscosity enhancer, and sweetners/flavoring agents known in the art. As immediate release tablets, these compositions may contain microcrystalline cellulose, dicalcium phosphate, starch, magnesium stearate and lactose and/or other excipients, binders, extenders, disintegrants, diluents and lubricants known in the art. When administered by nasal aerosol or inhalation, these compositions are prepared according to techniques well-known in the art of pharmaceutical formulation and may be prepared as solutions in saline, employing benzyl alcohol or other suitable preservatives, absorption promoters to enhance bioavailability, fluorocarbons, and/or other solubilizing or dispersing agents known in the art. The injectable solutions or suspensions may be formulated according to known art, using suitable non-toxic, parenterally- acceptable diluents or solvents, such as mannitol, 1,3-butanediol, water, Ringer's solution or isotonic sodium chloride solution, or suitable dispersing or wetting and suspending agents, such as sterile, bland, fixed oils, including synthetic mono- or diglycerides, and fatty acids, including oleic acid. When rectally administered in the form of suppositories, these compositions may be prepared by mixing the drug with a suitable non-irritating excipient, such as cocoa butter, synthetic glyceride, esters, or polyethylene glycols, which are solid at ordinary temperatures, but liquidify and/or dissolve in the rectal cavity to release the drug. The compounds of this invention can be administered orally to humans in a dosage range of 1 to 100 mg/kg body weight in divided doses. One preferred dosage range is 1 to 10 mg/kg body weight orally in divided doses. Another preferred dosage range is 1 to 20 mg/kg body weight orally in divided doses. It will be understood, however, that the specific dose level and frequency of dosage for any particular patient may be varied and will depend upon a variety of factors including the activity of the specific compound employed, the metabolic stability and length of action of that compound, the age, body weight, general health, sex, diet, mode and time of administration, rate of excretion, drug combination, the severity of the particular condition, and the host undergoing therapy. The present invention is also directed to combinations of the HTV reverse transcriptase inhibitor compounds with one or more agents useful in the treatment of AIDS. The compounds of this invention can be administered in combination with other compounds that are HTV reverse transcriptase inhibitors, and/or with compounds that are HTV protease inhibitors. For example, the compounds of this invention may be effectively administered, whether at periods of pre- exposure and/or post-exposure, in combination with effective amounts of the AIDS antivirals, such as those in the following Table VIE. When used in a combination treatment with compounds of the instant invention, dosage levels of HTV protease inhibitors of the order of 0.02 to 5.0 or 10.0 grams-per-day are useful in the treatment or prevention of the above-indicated conditions, with oral doses two-to- five time higher. For example, infection by HTV is effectively treated by the administration of from 10 to 50 milligrams of the HTV protease inhibitor per kilogram of body weight from one to three times per day. It will be understood, however, that the specific dose level and frequency of dosage for any particular patient may be varied and will depend upon a variety of factors including the activity of the specific compound employed, the metabolic stability and length of action of that compound, the age, body weight, general health, sex, diet, mode and time of administration, rate of excretion, drug combination, the severity of the particular condition, and the host undergoing therapy. Dosages of HTV reverse transcriptase inhibitors, when used in a combination treatment with compounds of the instant invention, are comparable to those dosages specified above for the instant compounds. -. It will be understood that the scope of combinations of the' compounds of this invention with AIDS antivirals is not limited by Table VIE but includes in principle any combination with any pharma¬ ceutical composition useful for the treatment of AIDS. TABLE VEI Drug Name Manufacturer Indication ddl Bristol-Myers AIDS, ARC Dideoxyinosine (New York, NY) Dideoxycytidine; Hoffman-La Roche AIDS, ARC ddC (Nutley, NJ) Zidovudine; AZT Burroughs Wellcome AIDS, adv, ARC (Rsch. Triangle Park, pediatric AIDS, NC) Kaposi's sarcoma, asymptomatic HTV infection, less severe HTV disease, neurological involvement, in combination with other therapies. L-697,661 Merck AIDS, ARC, (Rahway, NJ) asymptomatic HTV positive, also in combination with AZT. TABLE VEI (Cont'd Drug Name Manufacturer Indication L-696-229 Merck AIDS, ARC, (Rahway, NJ) asymptomatic HTV positive, also in combination with AZT. L-735,524 Merck AIDS, ARC, (Rahway, NJ) asymptomatic HTV positive, also in combination with AZT. L-738,372 Merck AIDS, ARC, (Rahway, NJ) asymptomatic HTV positive, also in combination with AZT. L-738,872 Merck AIDS, ARC, (Rahway, NJ) asymptomatic HTV positive, also in combination with AZT. Compounds of Table VIE are the following: L-697,661 is 3-([(4,7-dichloro-l,3-benzoxazol-2-yl)-methyl]-amino)-5-ethyl-6- methyl-pyridin-2(lH)-one; L-696,229 is 3-[2-(l,3-benzoxazol-2- yl)ethyl]-5-ethyl-6-methyl-pyridin-2(lH)-one; L-735,524 is an HTV protease inhibitor with the chemical name N-(2(R)-hydroxy-l(S)- indanyl)-2(R)-phenylmethyl-4-(S)-hydroxy-5-(l-(4-(3-pyridyl-methyl)- 2(S)-N'-(t-butylcarboxamido)piperazinyl))pentaneamide; L-738,372 is 6-chloro-4(S)-cyclopropyl-3,4-dihydro-4-((2-pyridyl)-ethynyl)- quinazolin-2(lH)-one; L-738,872 is N-tert-butyl-l-[2'-(R)-hydroxy-4'- phenyl-3'(S)-[3"(R)-[l , ",l'"-dioxo-2'"(R)-methylethyl]tetrahydro- thienyloxycarbonylamino]-butyl]-4-[4'-(2"-chloro-6"-methyl)pyridyl- methyl] -piperazine-2(S)-carboxamide. REVERSETRANSCRE ASEASSAY The assay measures the incorporation of tritiated deoxy- guanosine monophosphate by recombinant HIV reverse transcriptase (HTV RTR) (or other RT) into acid-precipitable cDNA at the Km values of dGTP and poly r(C)-oligo d(G)l2-18- The inhibitors of the present invention inhibit this incorporation. Thirty μL of a reaction mixture containing equal volumes of: 500 mM Tris-HCl (pH 8.2), 300 mM MgCl2, 1200 mM KCl, 10 mM DTT, 400 μg/mL poly r(c)«oligo d(G) [prepared by dissolving 1.5 mg (25 U) poly r(C)-oligo d(G) in 1.5 ml sterile distilled H2θ and diluting to 400 μg/ml], 0.1 μCi/μl [3H] dGTP, 160 μM dGTP, was added to 10 μl sterile distilled H2θ, 2.5 μl of potential inhibitor and 10 μL of 5 nM purified HTV RTR in tubes. The mixture was incubated at 37°C for 45 minutes. After incubation is complete, the tubes were cooled in ice for 5 minutes. Ice-cold 13% TCA containing 10 mM NaPPi (200 μl) are added and the mixture incubated on ice for 30 minutes. The precipitated cDNA is removed by filtration using presoaked glass filters [TCA, NaPPi]. The precipitate is then washed with IN HCI, 10 mM NaPPi. The filter discs are then counted in a scintillation counter. Under these conditions [dGTP] and poly r(C)»oligo d(G)l2-18 each are approximately equal to the appropriate Km value. Approximately 5-6,000 cpm of [^H] dGMP are incorporated into acid- precipitable material. The RT reaction is concentration- and time- dependent. DMSO (up to 5%) does not affect enzyme activity. Calculated IC50 values for the tested compounds of this invention vary from about 3 nM to more than 300 μM. The IC50 values of the most preferred compounds range from about 3 nM to about 35 nM. INHIBΓΓION OF VIRUS SPREAD A. Preparation of HTV-infected MT-4 Cell Suspension MT cells were infected at Day O at a concentration of 250,000 per ml with a 1:2000 dilution of fflV-1 strain IEb stock (final 125 pg p24/ml; sufficient to yield < 1% infected cells on day 1 and 25- 100% on day 4). Cells were infected and grown in the following medium: RPMI 1640 (Whittaker BioProducts), 10% inactivated fetal bovine serum, 4 mM glutamine (Gibco Labs) and 1:100 Penicillin- Streptomycin (Gibco Labs). The mixture was incubated overnight at 37 °C in 5% CO2 atmosphere. B. Treatment with Inhibitors Serial two-fold dilutions of compound were prepared in cell culture medium. At Day 1, aliquots of 125 μl of compound were added to equal volumes of HTV-infected MT-4 cells (50,000 per well) in a 96-well microtiter cell culture plate. Incubation was continued for 3 days at 37°C in 5% CO2 atmosphere. C. Measurement of Virus Spread Using a multichannel pipettor, the settled cells were resuspended and a 125 μl harvested into a separate microtiter plate. After the settling of the cells, the plates were frozen for subsequent assay of the supernatant for HTV p24 antigen. The concentration of HTV p24 antigen was measured by an enzyme immunoassay, described as follows. Aliquots of p24 antigen to be measured were added to microwells coated with a monoclonal antibody specific for HTV core antigen. The microwells were washed at this point, and at other appropriate steps that follow. Biotinylated HTV- specific antibody was then added, followed by conjugated streptavidin- horseradish peroxidase. A color reaction occurs from the added hydrogen peroxide and tetramethylbenzidine substrate. Color intensity is proportional to the concentration of HTV p24 antigen. The cell culture inhibitory concentration (CIC95) for each compound is defined as that concentration which inhibited by greater than 95% the spread of infection, as assessed by a greater than 95% reduction in p24 antigen production relative to untreated controls. The tested compounds of the present invention were found to have CIC95 values ranging from about 3 nM to about 400 nM for preferred species, and up to about 40 μM for others. EXAMPLE 1 Preparation of N-(3-pyridylmethyl)-5-chloro-3-phenylthioindole-2- carboxamide Step A: 5-Chloro-3-phenylthioindole-2-carboxylic acid To a suspension of sodium hydride (3.0 g, 60% dispersion in oil, 0.076 mol) in dimethylformamide (125 mL) was added 5- chloroindole-2-carboxylic acid (5.0 g, 0.0255 mol) and phenyldi¬ sulfide (6.1 g, 0.028 mol). The reaction was heated under nitrogen at 50°C overnight. The reaction was cooled, and additional sodium hydride (1.8 g) and phenyldisulfide (3.6 g) were added and heating continued for 1 h. The reaction was cooled and the dimethylformamide distilled in vacuo. The residue was partitioned between ethyl acetate and water. The aqueous layer was separated and the pH adjusted to pHl with 10% aqueous hydrochloric acid. The aqueous phase was extracted with ethyl acetate, and the ethyl acetate extract was washed with water and saturated brine, and dried over magnesium sulfate. The crude product was recrystallized from ethyl acetate in hexane to afford the title compound as an off-white solid. Step B: N-(3-pyridylmethyl)-5-chloro-3-phenylthioindole-2- carboxamide Benzotriazol- 1 -yloxytris(dimethylamino)phosphonium hexafluorphosphate (0.73 g, 1.6 mmol) was added to a solution of 5- chloro-3-phenylthio-indole-2-carboxylic acid (0.50 g, 1.6 mmol), 3- aminomethylpyridine (0.35 g, 3.2 mmol) and triethylamine (0.50 mL, 3.2 mmol) in degassed dimethylformamide (25 mL). The reaction was stirred at room temperature overnight. The precipitated product was filtered and the filter cake washed well with water. The solid was 5 ' triturated with 30% ethyl acetate in hexane, filtered and dried at 60 σ C in vacuo for 72 h. The title compound was obtained as an off-white solid, mp 240-241°C. Analysis calculated for C21H16CIN3OSO.25 H2O: C, 63.31; H, 4.17; N, 10.54 ! ° Found: C, 63.34; H, 4.06; N, 10.71 NMR (DMSO-d6): δ 12.54 (1H, s), 8.91 (1H, t, J=6 Hz), 8.51 (1H, s), 8.42 (1H, d, J=5 Hz), 7.58 (2H, m), 7.45 (1H, m), 7.25 (4H, m), 7.15 (1H, t, J=7 Hz), 7.04 (2H, d, J=8 Hz), 4.58 (2H, d, J=6 Hz). 15 EXAMPLE 2 Preparation of Methyl 5-chloro-3-phenylthioindole-2-carboxylate Oxalyl chloride (0.70 mL, 9.6 mmol) was added to a solution of 5-chloro-3-phenylthioindole-2-carboxylic acid (0.97 g, 3.2 20 mmol) in chloroform (50 mL) under nitrogen. The reaction was refluxed for 3 h, cooled and reduced to dryness in vacuo. The resulting solid was dissolved in chloroform and added to methanol at 0°C. The methanol was removed in vacuo and the crude product chromato- graphed on silica gel with 20% ethyl acetate in hexane. The title 25 compound was obtained as a solid, mp 193-196°C. Analysis calculated for C 16H 12CINO2S C, 60.47; H, 3.81; N, 4.42 Found: C, 60.09; H, 3.50; N, 4.67 0 EXAMPLE 3 Preparation of Ethyl 5-chloro-3-benzylindole-2-carboxylate The title compound was prepared according to the procedure described by Inaba, S., et aL, Chem. Pharm. Bull., 24, 1076- 1082 (1976). Recrystallization from benzene gave the title compound as pale yellow needles, mp 196-197°C. Analysis calculated for C 1 sH 16CINO2 C, 68.90; H, 5.13; N, 4.46 Found: C, 68.64; H, 5.10; N, 4.56 EXAMPLE 4 Preparation of 2-Phenylsulfinylmethyl-3-phenylthioindole Step A: 2-Hydroxymethylindole A suspension of lithium aluminum hydride (2.0 g, 0.20 mol) in tetrahydrofuran (100 mL) was cooled with stirring to 0°C under nitrogen. A solution of ethyl indole-2-carboxylate (10.0 g, 0.052 mol) in tetrahydrofuran was added dropwise, maintaining the reaction temperature between 0-5°C. After 1 h, the reaction was quenched with saturated sodium potassium tartrate solution. The reaction was filtered and the filter cake washed well with tetrahydrofuran. The tetrahydro¬ furan was evaporated in vacuo and the residue partitioned between ethyl acetate and water. The ethyl acetate solution was washed with water, saturated brine, dried over magnesium sulfate, filtered and freed of solvent. The title compound was obtained as a yellowish solid. NMR (CDCI3): δ 8.18 (1H, bs), 7.57 (1H, d, J=8 Hz), 7.35 (1H, d, J=8 Hz), 7.26 (1H, s), 7.18 (1H, dt, J=l, 8 Hz), 7.10 (1H, dt, J=l, 8 Hz), 6.41 (1H, bs), 4.84 (2H, s). Step B: 2-Phenylthiomethylindole 2-Hydroxymethylindole (6.94 g, 0.047 mol) and phenyldisulfide (10.8 g, 0.049 mol) were dissolved in tetrahydrofuran (200 mL) and cooled to 0°C under nitrogen. Tri-n-butylphosphine (11.7 mL, 0.047 mol) was added and the reaction stirred for 1 h. Additional phenyldisulfide (1.5 g, 0.007) and tri-n-butylphosphine (5.1 mL, 0.20 mol) was added, and the reaction stirred at room temperature until complete. The tetrahydrofuran was removed in vacuo and the residue chromatographed on silica gel eluting with 5% ethyl acetate in hexane. The title compound was obtained as clear colorless plates, mp 100-101.5°C. Analysis calculated f or C j 5H 13NS C, 75.27, H, 5.47, N, 5.85 Found: C, 74.52, H, 5.39, N, 5.95 Step C: 3-Phenylthio-2-phenylthiomethylindole A suspension of sodium hydride (0.37 g 60% dispersion in oil, 9.4 mmol) in dimethylformamide (50 mL) was cooled to 0°C. 2-Phenylthiomethylindole (1.5 g, 6.3 mmol) was added portionwise, and the reaction stirred at 0°C for 15 min. Phenyldisulfide (1.5 g, 6.9 mmol) was added and the reaction stirred at 20°C for 6 h. The reaction was quenched with water and extracted with ethyl acetate. The organic extract was washed with water, saturated brine and dried over magnesium sulfate. Filtration and evaporation of solvent left an oil which was purified by medium pressure chromatography on silica gel using 5% ethyl acetate in hexane. The title compound was obtained as an oil. Analysis calculated for C2lHi7NS2*H2θ-0.15-C4Hgθ2 C, 68.50; H, 5.33; N 3.60 Found: C, 68.40; H, 4.65; N, 3.86 Step D: 2-Phenylsulfinylmethyl-3-phenylthioindole A solution of 3-phenylthio-2-phenylthiomethylindole (0.750 g, 2.94 mmol) in methanol (100 mL) was cooled to 0°C with stirring. Monoperoxyphthahc acid magnesium salt (0.908 g, 80% peracid) in methanol (50 mL) was added slowly dropwise. After addition, the reaction was stirred an additional 30 min., then quenched with 10% aqueous sodium thiosulfate (2 mL). The methanol was removed in vacuo, and the residue partitioned between ethyl acetate and water. The organic phase was washed successively with water and saturated brine, then dried over magnesium sulfate. Filtration and concentration of the filtrate in vacuo gave an oil which was purified by chromatography on silica gel using 20-30% ethyl acetate in hexane. The title compound was obtained as a foam, mp 71-74°C. Exact mass calculated for C21H17NOS2: 364.082982. Found: 364.084549. NMR (DMSO-d6) δ 11.82 (1H, s), 7.50 (6H, m), 7.23 (1H, d, J=8 Hz), 7.15 (3 H, m) 7.05 (2H, m) 6.90 2H, m), 4.43 (1H, d, J=13 Hz), 4.38 (lH, d, J=13 Hz). EXAMPLE 5 Preparation of 2-Phenylcarboxamidomethyl-3-phenylthioindole Step A: 3-Phenythioindole-2-carboxamide The title compound was prepared from 3-phenylthioindole- 2-carboxylic acid (prepared according to the procedure described by Atkinson, J.G. et al., Synthesis, p. 480-481 (1988), (4.01 g, 0.015 mol), ammonia (large excess), and benzotriazol-l-yloxytris(dimethyl- amino)phosphonium hexafluorphosphate (7.2 g, 0.016 mol) in dimethylformamide according to the general procedure described in Example 1 for the preparation of N-(3-pyridylmethyl)-5-chloro-3- phenylthio-2-carboxamide. The title compound was obtained as a pale yellow solid. Step B: 2-Aminomethyl-3-phenylthioindole A solution of 3-phenylthioindole-2-carboxamide (1.9 g, 7.1 mmol) in tetrahydrofuran was cooled under nitrogen to 0°C and treated with neat boranedimethylsulfide complex (7.1 mL, 0.070 mol). The reaction was refluxed for 7 h, cooled to 0°C and quenched with 10% aqueous hydrochloric acid. The solution was adjusted to pH 8 with 20% aqueous sodium hydroxide. The reaction was extracted with ethyl acetate and the organic extract washed with saturated brine, and dried over magnesium sulfate. The title compound was obtained as a pale yellow oil. Step C: 2-Phenylcarboxamidomethyl-3-phenylthioindole 2-Aminomethyl-3-phenylthioindole (0.85 g, 3.3 mmol) was dissolved in chloroform (15 mL) and cooled under nitrogen to 0°C. Pyridine (2.7 mL, 33 mmol) was added, followed by benzoyl chloride (1.1 mL, 10 mmol). The reaction was stirred at 20°C for 1 h and 10% aqueous hydrochloric acid added. The layers were separated and the organic phase washed successively with water, saturated sodium bicarbonate and saturated brine. The chloroform solution was dried over magnesium sulfate, filtered and evaporated to dryness. The resulting oil was chromatographed on silica gel with 5% ethyl acetate in methylene chloride. The title compound was obtained as a solid, mp 64- 65°C. Analysis calculated for C22H 18N2OS.O.2 H2O C, 73.00; H, 5.08; N, 7.74 Found: C, 72.93; H, 5.02; N, 7.66 EXAMPLE 6 Preparation of 2-(N-Phenylacetamido)-3-phenyl-thioindole and 2-(N- Phenylacetamido -l-(phenyl-carbamoylV3-phenylthioindole 2-Methyl-3-phenylthioindole (0.50 g, 2.1 mmol) (prepared according to the procedure described by Atkinson, J. G., et al., Synthesis, p. 480-481 (1988), was dissolved in dry tetrahydrofuran and cooled under nitrogen to -78°C. A solution of n-butyllithium in hexane (0.83 mL, 2.5 M) was added via syringe. Carbon dioxide was bubbled into the reaction mixture over a period of several minutes; unreacted carbon dioxide was removed by freezing the reaction at liquid nitrogen temperature under high vacuum and warming to -78°C. A solution of t-butyllithium in hexane was added (1.35 mL, 1.7 M) and the reaction stirred for 20 min. Phenylisocyanate (0.23 mL, 2.1 mmol) in tetrahydrofuran (1.5 mL) was added and the reaction stirred at 20°C overnight. The reaction was diluted with water and extracted with ethyl acetate. The organic phase was washed with saturated brine and dried over magnesium sulfate. Filtration and evaporation of solvent left an amber oil. The crude products were chromatographed on silica gel eluting successively with 15%, 20%, and 40% ether in hexane. 2-(N- Phenylacetamido)-3-phenylthioindole was isolated as a solid, mp 66- 68°C. Analy sis calculated for C22H 18N2OS C, 72.98; H, 5.01; N, 7.73 Found: C, 72.99; H, 4.87; N, 7.52 Later fractions contained 2-(N-phenylacetamido)-l- (phenylcarbamoyl)-3-phenylthioindole, mp 123-125°C. Analysis calculated for C29H23N3O2S C, 70.28, H, 4.67, N, 8.47 Found: C, 70.37, H, 4.61; N, 8.34 EXAMPLE 7 Preparation of 2-(2-Oxo-2-furan-3-yl ethyl-3-phenylthioindoIe Step A: N-Methoxy-N-methylfuran-3-carboxamide The title compound was prepared from furan-3-carboxylic acid (3.4 g, 0.030 mol), N,0-dimethylhydroxylamine hydrochloride hydrochloride (2.9 g, 0.030 mol) triethylamine (8.3 mL, 0.060 mol) and benzotriazol-1 -yloxytris(dimethylamino)phosphonium hexafluorphosphate (13.3 g, 0.030 mol) according to the general procedure described in Example 1 for N-(3-pyridylmethyl)-5-chloro-3- phenylthio-2-carboxamide. NMR (DMSO-d6) δ 8.25 (1H, s), 7.75 (1H, s), 3.70 (3H, s), 3.22 (3H, s). Step B: 2-(2-Oxo-2-furan-3-ynethyl-3-phenylthioindole The title compound was prepared from N-methoxy-N- methylfuran-3-carboxamide (0.32 g, 2.1 mmol), and 2-methyl-3- phenylthioindole (0.50 g, 2.1 mmol) according to the general procedure described in Example 6 for the preparation of 2-(N-phenylacetamido)- 3-phenyl-thioindole. The crude product was chromatographed on silica gel with chloroform. The title compound was obtained as a pale yellow solid, mp 127-129°C. Analysis calculated for C20H 15NO2S C, 72.05; H, 4.54; N, 4.20 Found: C, 72.08; H, 4.57; N, 4.24 EXAMPLE 8 Preparation of 2-Benzoyl-5-chloro-3-phenylthioindole Step A: N Mem'oxy-N-methyl-5-chloro-3-phenylthioindole-2- carboxamide The title compound was prepared from 5-chloro-3-phenyl- thioindole-2-carboxylic acid (1.0 g, 3.30 mmol)) N,0-dimethyl- hydroxylamine hydrochloride (0.64 g, 6.6 mmol), triethylamine (1.0 mL, 7 mmol) and benzotriazol-l-yloxytris(dimethylamino)phosphonium hexafluorphosphate (1.64 g, 3.6 mmol) in dimethylformamide according to the general procedure described in Example 1 for the preparation of N-(3-pyridylmethyl)-5-chloro-3-phenylthio-2- carboxamide. Step B: 2-Benzoyl-5-chloro-3-phenylthioindole N-Methoxy-N-methyl-5-chloro-3-phenylthioindole-2- carboxamide (0.24 g, 0.69 mmol) was dissolved in dry tetrahydrofuran (5 mL) and cooled to -78°C under nitrogen. A solution of phenylmagnesium chloride in tetrahydrofuran (0.81 mL, 2M) was added via syringe and the reaction warmed to 20°C overnight. Water and ethyl acetate were added to the reaction and then separated. The organic phase was washed with water, 5% aqueous hydrochloric acid, saturated sodium bicarbonate, saturated brine, and dried over magnesium sulfate. Filtration and evaporation of solvent gave the crude product which was chromatographed on silica gel with 10% ether in hexane. The title compound was obtained as a solid, mp 154-155°C. Analysis calculated for C21 H 14CINOS C, 69.32; H, 3.88; N, 3.85 Found: C, 68.61; H, 3.83; N, 3.83 EXAMPLE 9 Preparation of 2-(2-Benzoxazol-2-ylethylV3-phenylthioindole Step A: N-Methoxy-N-methyl-3-phenylthiolndole-2-carboxamide The title compound was prepared from 3-phenylthioindole- 2-carboxylic acid (1.0 g, 3.7 mmol), N,0-dmiethylhydroxylamine hydrochloride (0.54 g, 5.5 mmol), triethylamine (1.5 mL, 11 mmol) and benzotriazol- 1 -y loxytris(dimethylamino)phosphonium hexafluorphosphate (1.64 g, 3.7 mmol) according to the procedure described in Example 1 for N-(3-pyridylmethyl)-5-chloro-3-phenylthio- 2-carboxamide. Step B: 3-Phenylthioindole-2-carboxaldehvde N-Methoxy-N-methyl-3-phenylthioindole-2-carboxamide (1.57 g, 5.26 mmol) was dissolved in tetrahydrofuran (150 mL) and cooled to 0°C under nitrogen. A solution of lithium aluminum hydride in tetrahydrofuran (5.76 mL, IM) was added slowly via syringe and the reaction stirred a total of 1.5 h. Ethyl acetate (30 mL) was added, followed by saturated sodium potassium tartrate solution. The layers were separated and the organic phase washed with saturated brine and dried over magnesium sulfate. Filtration and evaporation of solvent gave the title compound as a yellow solid. Step C: trans-2-(2-Benzoxazol-2-ylethenylV3-phenylthioindole n-Butyllithium in hexane (3.47 mL, 2.5 M) was added to a solution of [(benzoxal-2-yl)-methyl]diethylphosphonate (2.34 g, 8.68 mmol) in tetrahydrofuran (50 mL) at -78°C under nitrogen. The reaction was stirred for 20 min., and warmed to -20°C. A solution of 3-phenylthioindole-2-carboxaldehyde (1.10 g, 4.34 mmol) in tetrahydrofuran (30 mL) was added and the reaction stirred at 20°C overnight. Ethyl acetate and water were added and the layers separated. The organic layer was washed with saturated brine and dried over magnesium sulfate. The crude product was triturated with 1:1 hexane ethyl acetate and collected by filtration. The title compound was obtained as a yellow solid, mp 260°C. Analysis calculated for C23H 16N2OS C, 72,32; H, 4.58; N, 7.33 Found: C, 72.41; H, 4.50; N, 7.44 Step D: 2-(2-Benzoxazol-2-ylethyl ' )-3-phenylthioindole A solution of trans-2-(2-benzoxazol-2-ylethenyl)-3- phenylthioindole (0.420 g, 1.14 mmol) in 1:1 methanol/tetrahydrofuran (250 mL) was stirred under 1 atmosphere of hydrogen in the presence of 10% palladium on charcoal (100 mg). Additional catalyst was added as needed to drive the reaction to completion. The catalyst was removed by filtration, and the filtrate concentrated in vacuo. The resulting solid was triturated with 10% ethyl acetate in hexane and collected by filtration to afford the title compound, mp 192-193°C. Analysis calculated for C23H \ 8N2OS C, 72.80; H, 5.04; N, 7.38 Found: C, 72.78; H, 4.95; N, 7.45 EXAMPLE 10 Preparation of N-2-Furanylmethyl-5-chloro-3-phenylthioindole-2- carboxamide The title compound was prepared according to the procedure described in Example 1, Step B, except substituting 2- aminomethylfuran for 3-aminomethylpyridine. The dimethylformamide was removed in vacuo. and the residue triturated with 1:1 ethyl acetate-hexane and filtered. Recrystallization from acetonitrile gave the title compound, mp 214°C. Analysis calculated for C20H 15CIN2O2S C, 62.74; H, 3.95; N, 7.32 Found: C, 62.27; H, 3.88; N, 7.41 NMR (DMSO-d6): δ 12.55 (1H, s), 8.72 (1H, t, J=6 Hz), 7.55 (1H, m), 7.54 (1H, d, J=8 Hz), 7.45 (1H, d, J=2 Hz), 7.15 (1H, tt, J=7, 1 Hz), 7.08 (1H, s), 7.06 (1H, d, J= 8 Hz), 6.35 (1H, m), 6.18 (1H, m), 4.56 (2H, d, J=6 Hz). EXAMPLE 11 Preparation of N-3-Pyridyl-5-chloro-3-phenylthioindole-2-carboxamide The title compound was prepared according to the procedure described in Example 1, Step B, except substituting 3- aminopyridine for 3-aminomethyl-pyridine. The dimethylformamide was removed in vacuo, and the residue triturated with 1:1 ethyl acetate- hexane and filtered. Chromatography on silica gel with 40% ethyl acetate in hexane gave the title compound, mp 255-256°C. Analysis calculated for C20H15CIN3OS C, 63.24; H, 3.98; N, 10.74 Found: C, 62.59; H, 3.86; N, 11.06 NMR (DMSO-d6): δ 12.72 (IH, s), 10.55 (IH, s), 8.85 (IH, d, J=3 Hz), 8.35 (IH, dd, J=5, 1 Hz), 8.14 (IH, dm, J =8 Hz), 7.60 (IH, d, J=9 Hz), 7.48 (IH, d, J=2 Hz), 7.40 (IH, dd, J=9, 2 Hz), 7.25 (2H, t, J=7 Hz), 7.16 (IH, m), 7.11 (2H, t, J=7 Hz). EXAMPLE 12 Preparation of N-Ethyl-5-chloro-3-phenylthioindole-2-carboxamide The title compound was prepared according to the procedure described in Example 1, Step B, except substituting ethylamine for 3-aminomethylpyridine. The dimethylformamide was removed in vacuo, and the residue triturated with 1:1 ethyl acetate- hexane and filtered. Recrystallization from 2% methanol in ethyl acetate gave the title compound, mp 210-211°C. Analysis calculated for Ci7Hi5ClN2θS-0.5 H2O C, 60.08; H, 4.74; N, 8.24 Found: C, 60.00; H, 4.18; N, 8.52 NMR (DMSO-d6): δ 12.49 (IH, s), 8.31QH, t, J=6 Hz), 7.54 (IH, d, J=9 Hz), 7.43 (IH, d, J= 2 Hz), 7.27 (3H, m), 7.15 (IH, tt, J=7, 2 Hz), 7.07 (2H, m), 3.35(4H, m), 1.06 (3H, t, J=7 Hz). EXAMPLE 13 Preparation of N-3-Methoxybenzyl-5-chloro-3-phenylthioindole-2- ' carboxamide The title compound was prepared according to the procedure described in Example 1, Step B, except substituting 3- methoxybenzylamine for 3-amino-methylpyridine. The dimethyl¬ formamide was removed in vacuo, and the residue triturated with 1:1 0 ethyl acetate-hexane and filtered. Recrystallization from acetonitrile gave the title compound, mp 172°C. Analysis calculated for C23H 19ClN2θ2S»0.3 H2O C, 64.48; H, 4.61; N, 6.54 Found: C, 64.41; H, 4.38; N, 6.75 5 NMR (DMSO-d6): δ 12.55 (IH, s), 8.80 (IH, m), 7.55 (IH, d, J=8 Hz), 7.44 (IH, s), 7.25 (3H, m), 7.15 (2H, m), 7.05 (2H, d, J=7 Hz), 6.80 (3H, m), 4.54 (2H, d, J=6 Hz). EXAMPLE 14 0 Preparation of N-2-Methoxyethyl-5-chloro-3-phenyl-thioindole-2- carboxamide The title compound was prepared according to the procedure described in Example 1, Step B, except substituting 2- 5 methoxyethylamine for 3-amino-methylpyridine. The dimethyl¬ formamide was removed in vacuo, and the residue triturated with 1:1 ethyl acetate-hexane and filtered to give the title compound, mp 216- 217°C. Analysis calculated for C18H17CIN2O2S: 0.25 H2O C, 59.17; H, 4.83; N, 7.67 Found: C, 59.11; H, 4.75; N, 7.82 NMR (DMSO-d6): δ 12.54 (IH, s), 8.44 (IH, t, J=6 Hz), 7.54 (IH, d, J=9 Hz), 7.48 (IH, d, J=2 Hz), 7.28 (3H, m), 7.17 (IH, t, J=7 Hz), 7.10 (2H, m), 3.49 (2H, q, J=6 Hz), 3.37 (2H, t, J=6 Hz), 3.16 (3H, s). EXAMPLE 15 Preparation of N-4-Pyridylmethyl-5-chloro-3 -pheny l-thioindole-2- carboxamide The title compound was prepared according to the procedure described in Example 1, Step B, except substituting 4- aminomethylpyridine for 3-amino-methylpyridine. The dimethylformamide was removed in vacuo, and the residue triturated with 1:1 ethyl acetate-hexane and filtered. Recrystallization from acetonitrile gave the title compound, mp 228-229°C. Analysis calculated for C21H16CIN3OS: 0.2 H2O C, 63.45; H, 4.16; N, 10.57 Found: C, 63.33; H, 4.02; N, 10.50 NMR (DMSO-ds): δ 12.56 (IH, s), 8.92 (IH, t, J= 6 Hz), 8.38 (IH, d, J=4 Hz), 7.55 (IH, d, J=8 Hz), 7.47 (IH, s), 7.31 (IH, dd, J=8, 2 Hz), 7.25 (IH, d, J=7 Hz), 7.17 (2H, m), 7.05 (IH, d, J=7 Hz), 4.58 (2H, d, J=6 Hz). EXAMPLE 16 Preparation of N-2-Hydroxyethyl-5-chloro-3 -pheny lthioindole-2- carbox amide The title compound was prepared according to the procedure described in Example 1, Step B, except substituting 2- hydroxyethylamine for 3-amino-methylpyridine. The dimethyl¬ formamide was removed in vacuo, and the residue triturated with 1:1 ethyl acetate-hexane and filtered. Chromatography on silica gel with 2% methanol in chloroform gave the title compound, mp 222-223°C. Analysis calculated for C17H15CIN2O2S: 0.3 H2O C, 57.96; H, 4.46; N, 7.95 Found: C, 57.99; H, 4.26; N, 7.90 NMR (DMSO-d6): δ 12.50 (IH, s), 8.46 (IH, m), 7.55 (IH, d, J=9 Hz), 7.45 (IH, d, J=l Hz), 7.28 (3H, m), 7.17 (IH, t, J=6 Hz), 7.13 (2H, m), 4.85 (IH, t), 3.49 (IH, m), 3.43 (IH, m). EXAMPLE 17 Preparation of 5-Chloro-3-phenylτhioindole-2-carboxamide The title compound was prepared according to the procedure described inΕxample 1, Step B; except substituting an excess of ammonia gas for 3-aminomethylpyridine and triethylamine. The dimethylformamide and excess ammonia were removed in vacuo and the residue partitioned between ethyl acetate and 10% hydrochloric acid. The organic phase was washed with water, 5% sodium hydroxide and saturated brine, and then dried over magnesium sulfate. Filtration and evaporation gave a crude product which was chromatographed on silica gel with 30% ethyl acetate in hexane. The title compound was obtained as a white solid mp 213-215°C. Analysis calculated for Ci 5H11 C1N20S- I/3H2O C, 58.35; H, 3.81; N, 9.07 Found: C, 58.33; H, 3.64; N, 9.11 NMR (DMSO-d6): δ 12.52 (IH, bs), 8.06 (IH, s), 7.76 (IH, s), 7.55 (IH, d, J=9 Hz), 7.44 (IH, s), 7.28 (3H, m), 7.15 (IH, t, J=6 Hz), 7.06 (2H, d, J=8 Hz). EXAMPLE 18 Preparation of 5-Chloro-3-phenylthioindole-2-thiocarboxamide A solution of 5-chloro-3-phenylthioindole-2-carboxamide (3.8 g, 12.5 mmol) and [2,4-bis(4-methoxyphenyl)-l,3-dithia-2,4- diphosphetane-2,4-disulfide (Lawesson's reagent) (5.0 g, 12.5 mmol) in dry THF (110 mL) was refluxed under nitrogen for 16 h. The solvent was removed in vacuo and the residue chromatographed on silica gel with 10% ethyl acetate in hexane. The chromatographed product was triturated with hexane and the yellowish solid collected and dried to give the title compound, mp 217°C (decomposed). Analysis calculated for C \ 5H \\ CIN2S C, 56.50; H, 3.48; N, 8.79 Found: C, 56.75; H, 3.64; N, 8.59 NMR (DMSO-d6): δ 12.22 (IH, s), 10.31 (IH, s), 9.48 (IH, s), 7.50 (1H, d, J=8 Hz), 7.39 (IH, s), 7.25 (3H, m), 7.13 (IH, t, J=7 Hz), 7.01 (2H, d, J=7 Hz). EXAMPLE 19 Preparation of N-2-furanylmethyl-5-chloro-3-phenylthioindole-2- thiocarboxamide The title compound was prepared according to the procedure described for 5-chloro-3-phenyl-thioindole-2- thiocarboxamide except substituting N-2-furanylmethyl-5-chloro-3- phenylthioindole-2-carboxamide for 5-chloro-3-phenylthioindole-2- carboxamide. The crude product was chromatographed on silica gel with 3% ethyl acetate in hexane. The title compound was obtained as a bright yellow solid, mp 143-144°C. Analysis calculated for C20H 15CIN2OS2Η2O C, 57.61; H, 3.62; N, 6.72 Found: C, 57.56; H, 3.58; N, 6.52 NMR (DMSO-d6): δ 12.27 (IH, s), 10.73 (IH, s), 7.55 (2H, m), 7.39 (IH, s), 7.21 (4H, m), 6.98 (2H, d, J=7 Hz), 6.36 (2H, 4.96 (2H, s). EXAMPLE 20 Preparation of N-[l-(2(R)-hydroxypropyl)]-5-chloro-3-phenylthio- indole-2-carboxamide The title compound was prepared according to the procedure described in Example 1, Step B, except substituting 2(R)- hydroxy-1-propylamine for 3-amino-methylpyridine. The dimethylformamide was removed in vacuo and the residue triturated first with 20% ethyl acetate in hexane then by acetonitrile. The title compound was obtained as an off-white solid, mp 202-203 °C. Analysis calculated for C18H17CIN2O2SO.3 H2O C, 59.01; H, 4.67; N, 7.65 Found: C, 58.91; H, 4.59; N, 7.50 NMR (DMSO-d6): δ 12.52 (IH, s), 8.45 (IH, t, J=5 Hz), 7.55 (IH, d, J=8 Hz), 7.46 (IH, s), 7.25 (3H, m), 7.15 (3H, m), 4.89 (IH, d, J=5 Hz), 3.74 (IH, m), 3.38 (IH, m), 3.23 (IH, m), 1.00 (3H, d, J=6 Hz). EXAMPLE 21 Preparation of N-(2-pyridyl)methyl-5-chloro-3-phenylthioindole-2- carboxamide The title compound was prepared according to the procedure described in Example 1, Step B, except substituting 2- pyridylmethylamine for 3-aminomethylpyridine. The dimethyl¬ formamide was removed in vacuo and the residue triturated first with 30% ethyl acetate in hexane, then with acetonitrile. The title compound was obtained as a white solid, mp 209-210°C. Analysis calculated for C21H16CIN3OS C, 64.03; H, 4.10; N, 10.67 Found: C, 63.51; H, 3.97; N, 10.41 NMR (DMSO-d6): δ 12.58 (IH, s), 9.15 (IH, t, J=5 Hz), 8.46 (IH, d, J=5 Hz), 7.66 (IH, t, J=8 Hz), 7.57 (IH, d, J=8 Hz), 7.50 (IH, s), 7.25 (5H, m), 7.12 (3H, m), 4.68 (2H, d, J=5 Hz). EXAMPLE 22 Preparation of N-(3-methoxy-4-pyridyl)methyl-5-chloro-3-phenyl- thioindole-2-carboxamide Step 1 : Preparation of 4-cvano-2-methoxypyridine A solution of 2-chloro-4-cyanopyridine (1.25 g, 9.1 mmol), prepared as described by D. Libermann, N. Rist, F. Grumbach, S. Cals, M. Moyeux and A. Rouaix, Bull. Soc. Chim. France. 694 (1958), in methanol was treated with sodium methoxide (0.58 g, 10.9 mmol) and refluxed for 30 minutes. The reaction mixture was cooled, filtered and the filtrate concentrated in vacuo to obtain the crude product as an off-white solid. The crude product was chromatographed on silica gel with 20% ethyl acetate in hexane. The title compound was obtained as a white powder. Step 2: Preparation of 4-aminomethyl-2-methoxypyridine A solution of 4-cyano-2-methoxypyridine (0.55 g, 4.1 mmol) in ethanol was hydrogenated at 60 psi H2 in the presence of 10% Pd/C (100 mg). After 3.5 h the catalyst was removed by filtration through Super-Cel and the filtrate evaporated to give the title compound as a foam. Step 3: Preparation of N-(3-methoxy-4-pyridylmethyl)-5-chloro-3- phenylthioindole-2-carboxamide The title compound was prepared according to the procedure described in Example 1, Step B, except substituting 4- aminomethyl-2-methoxypyridine for 3-aminomethylpyridine. The dimethylformamide was removed in vacuo and the crude product purified by chromatography on silica gel with 20-40% ethyl acetate in hexane. The title compound was obtained as a white solid, mp 227- 228°C. Analysis calculated for C22H 1 %C 1 N3O2S C, 62.33; H, 4.28; N, 9.91 Found: C, 62.63; H, 4.21; N, 9.92 NMR (DMSO-d6): δ 12.58 (IH, s), 8.93 (IH), 8.37 (2H, d), 7.56 (IH, d), 7.47 (IH, s), 7.27 (3H, m), 7.18 (2H, m), 7.05 (2H, d), 4.59 (2H, d), 3.30 (3H, s). EXAMPLE 23 Preparation of N-(3-hydroxymethyl)benzyl-5-chloro-3-phenylthio- indole-2-carboxamide The title compound was prepared according to the procedure described in Example 1, Step B, except substituting 3- hydroxymethylbenzylamine for 3-amino-methylpyridine. The dimethylformamide was removed in vacuo and the crude product recrystallized from acetonitrile. The title compound was obtained as a white solid, mp 229-230°C. Analysis calculated for C22H 17C IN2O2S C, 64.61; H, 4.19; N, 6.85 Found: C, 64.20; H, 4.09; N, 6.85 NMR (DMSO-d6): δ 12.69 (IH, s), 10.33 (IH, s), 7.60 (3H, m), 7.49 (1.H, s), 7.30 (4H, m), 7.15 (4H, m), 5.22 (IH, t, J=7 Hz), 4.50 (2H, d, J=7 Hz). EXAMPLE 24 Preparation of N-(3-hydroxybenzyl)-5-chloro-3-phenylthioindole-2- carboxamide The title compound was prepared according to the procedure described in Example 1, Step B, except substituting 3- hydroxybenzylamine for 3-aminomethyl-pyridine. The dimethyl¬ formamide was removed in vacuo and the crude product was chromatographed on silica gel with 10% methanol in chloroform. The title compound was obtained as a white solid, mp 214-216°C. Analysis calculated for C22Hi7ClN2θ2S-0.3 H2O C, 63.77; H, 4.04; N, 6.76 Found: C, 63.92; H, 3.88; N, 6.49 NMR (DMSO-d6): δ 12.55 (IH, s), 9.34 (IH, s), 8.75 (IH, t, J=5 Hz), 7.53 (IH, d, J=8 Hz), 7.45 (IH, s), 7.1-7.65 (4H, m), 7.06 (2H, d, J=7 Hz), 7.01 (IH, t, J=8 Hz), 6.70 (IH, s), 6.62 (2H, m), 4.48 (2H, d, J=5 Hz). EXAMPLE 25 Preparation of 5-Chloro-3-phenylsulfonylindole-2-carboxamide (Compound 18 5-Chloro-3-phenylthioindole-2-carboxamide (0.177 g, 0.584 mmol) was dissolved in 25 mL chloroform and cooled to 0°C. 50% by weight meta-chloroperoxybenzoic acid (503 mg, 1.46 mmol) was added and the reaction stirred at 20°C for 6 hours. A 10% aqueous solution of sodium thiosulfate was added and the reaction vigorously stirred for 10 minutes. The layers were separated and the organic phase washed with saturated sodium chloride then dried over magnesium sulfate. The crude product was chromatographed over silica gel eluting with 40% ethyl acetate in hexane. The title compound was obtained as a white powder, mp 255-257°C. NMR (300 MHz, DMSO-d6): δ 13.05 (lH,s), 8.48(lH,s), 8.25(lH,s), 8.03(2H,d,J=8 Hz), 7.95(lH,s), 7.60(4H,m), 7.34(lH,d,J=8 Hz). Analysis calculated for C15H11CIN2O3S C, 53.82; H, 3.31; N, 8.37 Found: c, 53.74; H, 3.29; N; 8.34 EXAMPLE 26 Preparation of 5-Chloro-3-phenylsulfinylindole-2-carboxamide (Compound 17) A solution of magnesium monoperoxyphthahc acid (85% peracid) (11.8 mg, 0.024 mmol) in methanol (2 mL) was added dropwise to a solution of 5-chloro-3-phenylthioindole-2-carboxamide (14.5 mg, 0.048 mmol) in methanol (2 mL) at 0°C. The reaction was stirred at 20°C for 4 hours. A solution of 10% aqueous sodium thiosulfate was added and the reaction stirred vigorously for 10 minutes. Methanol was removed in vacuo and the residue partitioned between ethyl acetate and water. The ethyl acetate extract was washed with brine and dried over magnesium sulfate. The crude product was purified by column chromatography on silica gel with 30-40% ethyl acetate in hexane. The title compound was obtained as a white solid. NMR (DMSO-d6, 300 MHz) δ 12.53(1H, s), 8.35(lH,br s), 8.08(lH,br s), 7.83(lH,d,J=2 Hz), 7.71(2H,dJ=8 Hz), 7.52(4H,m), 7.30(lH,dd,J=9,2 Hz). EXAMPLE 27 Preparation of N-(2,6-difluorobenzyl)-5-chloro-3 -pheny 1-sulfonyl- indole-2-carboxamide Step A: 5-chloro-3-phenylsulfonylindole-2-carboxylic acid To a suspension of 5-chloro-3-phenylthio-indole-2- carboxylic acid (4.84 g, 0.016 mol) in chloroform (1200 mL) was added 55% m-chloroperoxybenzoic acid (12.5 g, 0.04 mol). The mixture was allowed to stir at room temperature for 40 hours. Filtration afforded the title compound as a colorless solid, mp 277- 280°C (dec). On partial evaporation a second crop of product was obtained. Step B: Product of reaction of 5-chloro-3-phenyl-sulfonylindole- 2-carboxylic acid with oxalyl chloride To a suspension of 5-chloro-3-phenylsulfonyl-indole-2- carboxylic acid (5.04 g, 0.015 mol) in chloroform (200 mL) was added oxalyl chloride (3.81 g, 0.03 mol). After addition of a catalytic amount of dimethylformamide (0.1 mL) the mixture was heated at a bath temperature of 60°C for 50 minutes. After cooling, the solid product, mp >300°C, was utilized directly without further purification. While based on mass spectral and NMR data, this product appears to be a symmetrical dimer, it behaves as a typical acid chloride in reactions with primary amines. Step C: N-(2,6-difluorobenzyl)-5-chloro-3-phenyl-sulfonylindole- 2-carboxamide 2,6-Difluorobenzylamine (0.430 g, 3.0 mmol) was added dropwise to the solution of the "acid chloride equivalent" from Step B (0.354 g, 1.0 mmol) in tetrahydrofuran solution (10 mL) cooled in an ice-acetone bath. The reaction mixture was allowed to warm to room temperature and left overnight. For work-up, ethyl acetate and water were added. The ethyl acetate phase was washed well with dilute hydrochloride acid, saturated aqueous sodium bicarbonate, and brine. After drying over magnesium sulfate and evaporation of the solvent, the residue was slurried with ethyl acetate and filtered to give the title compound, mp 274-280°C. Analysis calculated for C22H15CIF2N2O3SO.5H2O C, 56.24; H, 3.43; N, 5.96 Found: C, 56.12; H, 3.31; N, 5.97 NMR (DMSO-d6) δ 13.06 (IH, s), 9.41 (IH, t, J=5.5Hz), 7.95 (3H, m), 7.41-7.67 (m, 5H), 7.34 (IH, dd, J=9, 2Hz), 7.18 (2H, t, J=8Hz), 4.64 (2H, d, J=5.5Hz). EXAMPLE 28 Preparation of N-(4-pyridylmemyl)-5-chloro-3-phenyl-sulfinylindole- 2-carboxamide (29) Step A: Preparation of 5-chloro-3-phenylsulfinyl-indole-2- carboxylic acid To a suspension of 5-chloro-3-phenylthioindole-2- carboxylic acid (2.14 g, 0.007 mol) in chloroform (600 mL) was added 55% m-chloroperoxybenzoic acid (2.32 g, 0.0074 mol). The mixture cleared briefly and then solids appeared. After stirring overnight at room temperature, the title compound was obtained in pure form on filtration, mp 183-185°C. Step B: N-(4-pyridylmethyl)-5-chloro-3-phenylsulfinylindole-2- carboxamide To a mixture of 5-chloro-3-phenylsulfinylindole-2- carboxylic acid (0.096 g, 0.3 mmol), triethylamine (0.061 g, 0.6 mmol), 4-aminomethylpyridine (0.043 g, 0.4 mmol) in dry dimethylformamide was added benzotriazol-l-yloxytris(dimethyl- amino)phosphonium hexafluorophosphate (BOP reagent) (0.155 g, 0.35 mmol). The mixture was stirred at room temperature under nitrogen for three days. Following evaporation, the residue was partitioned between ethyl acetate and water. The ethyl acetate phase was separated and washed with dilute hydrochloric acid. The acidic extract was neutralized with aqueous sodium bicarbonate and the product extracted into ethyl acetate. The ethyl acetate extract was washed well with aqueous sodium bicarbonate, then brine, and dried over magnesium sulfate. Evaporation afforded a solid residue which was recrystallized from ethyl acetate to give the title compound, mp 233-235°C. Analysis calculated for C21H16CIN3O2S C, 61.54; H, 3.93; N, 10.25 Found: C, 61.39; H, 3.95; N, 10.36 NMR (DMSO-d6) δ 9.62 (IH, t, J=6 Hz), 8.53 (2H, d, J=6Hz), 7.80 (IH, d, J=2 Hz), 7.67 (2H, m), 7.64 (2H, d, J=9 Hz), 7.44-7.54 (3H, m), 7.33 (3H, m), 4.60 (2H, dq, J=9, 6 Hz). EXAMPLE 29 Preparation of N-[(S)- 1 -phenyl-2-hydroxyethyl]-5-chloro-3-ρhenyl- sulfonylindole-2-carboxamide (32) To a solution of the acid chloride dimer product from Example 27, Step B, (0.354 g, 1.0 mmol) in tetrahydrofuran (10 mL), cooled in an ice-acetone bath, was added a solution of (S)-(+)-2- phenylglycinol (0.343 g, 2.5 mmol). The mixture, after warming gradually to room temperature, was allowed to sit overnight. Ethyl acetate and water were added. The ethyl acetate phase was washed successively with dilute hydrochloric acid, water, saturated sodium bicarbonate and brine. After drying over magnesium sulfate and evaporation, the product was chromatographed on a 20 mm column containing 6 inches of 230-400 mesh silica gel. Elution with 40% ethyl acetate-methylene chloride gave pure title compound which, after evaporation, was crystallized from ethyl acetate-hexane to give the title compound, mp 155-160°C. Analysis calculated for C23H 19CIN2O4S C, 60.72; H, 4.21; N, 6.16 Found: C, 60.33; H, 4.13; N, 6.16 NMR (DMSO-d6): δ 13.05 (IH, s), 9.52 (IH, d, J=7.5 Hz), 7.95-8.48 (3H, m), 7.26-7.68 (10H, m), 5.13 (IH, q, J=7.5 Hz), 5.07 (IH, t=6 Hz), 3.75 (2H, 6Hz). EXAMPLE 30 N-(3-methoxybenzyl)-5-chloro-3-(2-thiazolyl)sulfonyl-indole-2- carboxamide (31) Step A: Preparation of 5-Chloro-3-(2-thiazolyl)thioindole-2- carboxylic Acid Using the procedure of Example 1, Step A, but substituting di-(2-thiazolyl)disulfide for phenyldisulfide, there was obtained the title compound, mp 242-244°C. Step B: Preparation of 5-Chloro-3-(2-thiazolyl)-sulfonylindole- 2-carboxylic Acid Using the procedure of Example 27, Step A, but substituting 5-chloro-3-(2-thiazolyl)thioindole-2-carboxylic acid for 5- chloro-3-phenylthioindole-2-carboxylic acid, there was obtained the title compound, mp 260-261 °C. Step C: Product of Reaction of 5-CMoro-3-(2-thiazolyl)sulfonyl- indole-2-carboxylic Acid with Oxalyl Chloride Using the procedure of Example 27, Step B, but substituting 5-chloro-3-(2-thiazolyl)sulfonylindole-2-carboxylic acid for 5-chloro-3-phenylsulfonylindole-2-carboxylic acid, there was obtained a solid product, mp>290°C, which was utilized directly in the next step. Step D: N-(3-methoxybenzyl)-5-chloro-3-(2-thiazolyl-sulfonyl)- indole-2-carboxamide To a solution of the 'acid chloride' product from Step C (0.181 g, 0.5 mmol) in tetrahydrofuran (5 mL), cooled in an ice- acetone bath, was added 3-methoxybenzylamine (0.205 g, 1.5 mmol). The mixture was allowed to warm to room temperature and then was left overnight with stirring. Ethyl acetate and water were added. The ethyl acetate layer, after separation, was washed with dilute hydrochloric acid, saturated sodium bicarbonate, and brine. After drying (magnesium sulfate) and evaporation, the solid residue was allowed, to stand in a small volume of ethyl acetate. Filtration gave the title product, mp 205-209°C. Analysis calculated for C20H 16CIN3O4S2 C, 52.00, H, 3.49, N, 9.10 Found: C, 51.88, H, 3.42, N, 9.07 (DMSO-d6) δ 9.43 (IH, t, J=6 Hz), 8.18 (IH, d, J=3 Hz), 8.02 (IH, d, J=3 Hz), 8.00 (IH, d, J=2 Hz), 7.58 (IH, d, J=8.5 Hz), 7.40 (IH, dd, J=8.5, 2 Hz), 7.28 (IH, t, J=8 Hz), 6.98-7.05 (2H, m), 6.85 (IH, dd, J=8, 2.5 Hz), 4.54 (2H, d, J=3.76 Hz). EXAMPLE 31 5-Chloro-3-(2-thiazolyl)sulfonylindole-2-carboxamide A solution of the 'acid chloride' product of Example 30, Step C, (0.50 g, 1.4 mmol) in tetrahydrofuran (25 mL) was added slowly to a solution of tetrahydrofuran saturated with ammonia at -10°C. The reaction mixture was allowed to warm gradually to room temperature and then was stirred overnight. After evaporation of the solvent, the residue was partitioned between ethyl acetate and water. The ethyl acetate extract was washed with saturated sodium bicarbonate and brine, and dried with magnesium sulfate. After evaporation of solvent, the residue was slurried in ethyl acetate and filtered to give the title compound, mp 292-294°C (dec). Analysis calculated for C12H8CIN3O3S2 C, 42.17; H, 2.36; N, 12.29 Found: C, 42.23; H, 2.35; N, 11.85 NMR (DMSO-d6) δ 8.39 (IH, br s), 8.34 (IH, br s), 8.24 (IH, d, J=3 Hz), 8.07 (IH, d, J=3 Hz), 8.00 (IH, dd, J=2, 0.6 Hz), 7.57 (IH, dd, J=9, 0.6 Hz), 7.40 (IH, dd, J=9, 2Hz). EXAMPLE 32 5-Chloro-3-phenylsulfonylindole-2-τhiocarboxamide Reaction of 5-chloro-3-phenylsulfonylindole-2- carboxamide with 2,4-bis(4-methoxyphenyl)-l,3-dithia-2,4- diphosphetane (Lawesson's reagent) according to the procedure of Example 18 gave the title compound. Chromatographic purification on silica gel was carried out using 30% ethyl acetate-methylene chloride, followed by 50% ethyl acetate-methylene chloride. The pure product had mp 207-210°C. Analysis calculated f or C \ 5H \ \ CIN2O2S2 C, 51.35; H, 3.16; N, 7.98 Found: C, 50.84; H, 3.08; N, 8.04 NMR (DMSO-d6) δ 12.90 (IH, s), 10.71 (IH, s), 10.70 (IH, s), 8.0-8.6 (2H, m), 7.84 (IH, d, J=2Hz), 7.54-7.66 (3H, m), 7.46 (IH, d, J=8.5Hz), 7.30 (IH, dd, J=8.5, 2Hz). EXAMPLE 33 Preparation of 3-phenylsulfonyl-5-chloroindole-2-carboxamide Step A: N-(phenylthio)succinimide To a partial solution of N-chlorosuccinimide (3.34 g, 25 mmol) in dry methylene chloride (30 mL), cooled in an ice bath and under an inert atmosphere, was added thiophenol (2.05 mL, 20 mmol) via syringe. After stirring for 1 hour, additional N-chlorosuccinimide (0.40 g, 3 mmol) was added. After 2.5 hours total, triethylamine (3.9 mL, 28 mmol) was added drop wise. Within 15 minutes the reaction mixture was diluted with methylene chloride, the solvent washed with dilute aq. HCI and the solvent then dried (Na2Sθ4), filtered through a pad of charcoal and evaporated. The residue was triturated with diethyl ether and the product collected by filtration to yield the title compound mp 115-116°C [lit. mp 115-116°C. J. Org. Chem.. 34. 51 (1969)]. This material was used as is. Step B: Ethyl 3-phenylthio-5-chloroindole-2-carboxylate To a partial suspension of ethyl 5-chloroindole-2- carboxylate (698 mg, 3.1 mmol) and N-(phenylthio)succinimide (683 mg, 3.3 mmol) in anhydrous methylene chloride (20 mL) at ambient temperature under an inert gas atmosphere was added boron trifluoride etherate (0.12 mL, 1.0 mmol). The reaction was momtored by tic (thin layer chromatography) until complete. After 2 hours, the reaction was diluted with chloroform and neutralized with aq. NaHCθ3. The organic layer was dried (Na2S04), filtered through a pad of charcoal, and the solvents evaporated. The residue was triturated with hexanes as the product crystallized out to yield the title product, mp 160-162°C [see Table E, mp 163-164°C]. This material was used as is. Step C: Ethyl 3 -phenylsulf onyl-5 -chloroindole-2-carboxylate Ethyl 3-phenylthio-5-chloroindole-2-carboxylate (642 mg, 1.94 mmol) was dissolved in chloroform (35 mL) and a dried (Na2S04) solution of m-chloroperoxybenzoic acid (55% pure, 1.30 g, 4.1 mmol) in chloroform (20 mL) was added dropwise. The progress of the oxidation was monitored by tic until complete. After 5 hours, the reaction was diluted with chloroform and some methanol and the solution washed with aq. NaHC03 and aq. Na2Cθ3. The dried (Na2S04) organic layer was filtered through a pad of charcoal and the solvents removed under reduced pressure. The residue was triturated with diethyl ether to yield the product. Crystallization from methylene chloride and diethyl ether gave analytically pure material, mp 201- 202°C. IH NMR (CDCI3) δ 9.63 (br s, IH), 8.58 (t, IH, J=0.7 Hz), 8.07 (d, 2H, J=7 Hz), 7.46-7.56 (m, 3H), 7.40 (m, 2H), 4.39 (ABq, 2H, J=7 Hz), 1.35 (t, 3H, J=7 Hz). Analysis calculated f or C 17H 14CINO4S C, 56.12; H, 3.88; N, 3.85 Found: C, 55.91; H, 3.95; N, 3.91 Step D: 3 -Pheny lsulf onyl-5 -chloroindole-2-carboxamide (Compound 18) A suspension of ethyl 3-phenylsulfonyl-5-chloroindole-2- carboxylate (596 mg, 1.64 mmol) in aqueous cone, ammonium hydroxide (10 mL) containing ammonium chloride (28 mg) was heated at 100°C for 3 hours in a sealed screw-top tube. The sealed tube was cooled in an ice bath as product crystallized out. The product was collected by filtration, rinsed with ice water, and dried to give the product, mp 253-254°C. EXAMPLE 34 Preparation of N-[(imidazol-2-yl)methyl]-3-phenyl-sulfonyl-5- chloroindole-2-carboxamide A suspension of 2-aminomethylimidazole dihydrochloride (256 mg, 1.5 mmol) [prepared as described in J. Org. Chem..43. 1603 (1978)] in dry tetrahydrofuran (6 mL) containing triethylamine (.42 mL, 3.0 mmol) was stirred at room temperature under an inert atmosphere for one hour. The dimeric acid chloride (179 mg, 0.25 mmol) [see Example 27, Step B] was added, followed by additional triethylamine (0.07 mL, 0.5 mmol) and the mixture was stirred for 12- 20 hours. The mixture was diluted with water and the product extracted into ethyl acetate. This organic layer was dried (Na2S04), filtered, and the solvents evaporated. The residue was triturated with ethyl acetate to give the product. Recrystallization from hot ethyl acetate gave analytically pure product, mp 276-278 °C. lH NMR (DMSO-d6) δ 9.50 (br t, IH, J=5.4 Hz), 8.07 (s, IH), 8.05 (s, IH), 8.00 (d, IH, J=1.2 Hz), 7.52-7.67 (m, 4H), 7.37 (dd, IH, J=1.5, 9 Hz), 7.03 (br s, 2H), 4.61 (d, 2H, J=5.4 Hz). Analysis calculated for C19H15CIN4O3S C, 55.00; H, 3.64; N, 13.50 Found: C, 54.67; H, 3.36; N, 13.37 EXAMPLE 35 Preparation of N-[(l-memylimidazol-2-yl)methyl]-3-phenylsulfonyl-5- chloroindole-2-carboxamide (19) Step A: 2-Aminomethyl-l -methylimidazole To a suspension of lithium aluminum hydride (114 mg, 3.0 mmol) in dry tetrahydrofuran (15 mL) at room temperature in an inert atmosphere was added solid l-methylimidazole-2-cafboxamide (185 mg, 1.5 mmol) [prepared according to J. Org. Chem.. 52. 4379 (1987)] in portions. After stirring the reaction mixture for 0.5 hour, the temperature was raised to 50°C for 3.5 hours. After cooling this reaction, satd. aq. Na2S04 (2 mL) was added to quench reaction and then powdered anhyd. Na2Sθ4. Filtration of this mixture to remove salts gave a dry solution of 2-aminomethyl-l-methyl-imidazole in tetrahydrofuran (~25 mL) which was used as is. Step B: N-[(l -methylimidazol-2-yl)methyl]-3-phenyl-sulfonyl-5- chloroindole-2-carboxamide A solution of the dimeric indole acid chloride (see Example 27, Step B) (358 mg, 0.5 mmol) in dry tetrahydrofuran (7 mL) was added dropwise to the above solution of 2-aminomethyl-l-methyl- imidazole in tetrahydrofuran, which was cooled in an ice bath. After 15 min. triethylamine (0.2 mL, 1.4 mmol) was added and the reaction mixture slowly warmed to room temperature over 12-20 hours. The reaction was diluted with water and the product extracted into 10% methanol/ethyl acetate. The extract was dried (Na2Sθ4), filtered through charcoal, and the solvents evaporated. The residue was triturated with ethyl acetate and the product collected by filtration. Recrystallization from hot methanol/ethyl acetate gave analytically pure material, mp 273-275°C. IH NMR (DMSO-d6) δ 9.48 (br t, IH, J=5 Hz), 8.05 (d, 2H, J=7 Hz), 7.98 (d, IH, J=2 hz), 7.52-7.67 (m, 4H), 7.35 (dd, IH, J=2, 9 Hz), 7.18 (d, IH, J=l Hz), 6.88 (d, IH, J=l Hz), 4.66 (d, 2H, J=5 Hz), 3.71 (s, 3H). Analysis calculated for C20H17CIN4O3S C, 56.00; H, 4.00; N, 13.06 Found: C, 55.77; H, 3.97; N, 13.41 The hydrochloride salt was obtained by addition of one equivalent of ethanolic HCI to the free base, mp 284-285°C with decomposition. Analysis calculated for C20H17CIN4O3SΗCI C, 51.62; H, 3.90: N, 12.04 Found: C, 51.21; H, 3.92; N, 11.55 EXAMPLE 36 Alternate Preparation of N-[(l-methylimidazol-2-yl)-methyl] 3- phenylsulfonyl-5-chloroindole-2-carboxamide To a partial suspension of N-[(imidazol-2-yl)-methyl] 3- phenylsulfonyl-5-chloroindole-2-carboxamide (Example 35) (42 mg, 0.1 mmol) in 1:1 methanol/tetrahydrofuran (4 mL) was added iodomethane (.05 mL, 0.8 mmol). The reaction was stirred for three days at room temperature. The solvents were removed under reduced pressure, aq. NaHCθ3 added and the product extracted into ethyl acetate/methanol. The organic layer was dried (Na2S04), filtered, and the solvents evaporated. The residue was purified by chromatography and the product eluted with 3% methanol/chloroform. Appropriate fractions were combined, the solvents evaporated, and the residue triturated with methylene chloride to give pure product. EXAMPLE 37 Preparation of N-[2-(imidazol-4-yl)ethyl]-3-phenyl-sulfonyl-5-chloro- indole-2-carboxamide (24) Carbonyldiimidazole (180 mg, 1.11 mmol) was added to a solution of 5-chloro-3-phenylsulfonylindole-2-carboxylic acid (Example 27, Step A) (336 mg, 0.5 mmol) cooled in an ice bath under an inert atmosphere. After 0.5 hours, histamine (125 mg, 1.12 mmol) was added to the yellow solution. After 5 hours the reaction was diluted with water and the product extracted into ethyl acetate. This organic layer was washed with dilute aq. NaHCθ3, dried (Na2S04), filtered through charcoal and the solvents evaporated. Trituration of this residue with methylene chloride gave the crude product. Crystallization from hot ethyl acetate gave analytically pure product, mp 220-221.5°C. IH NMR (DMSO-d6) δ 9.11 (br t, IH, J=5.4 Hz), 8.00 (s, IH), 7.98 (s, IH), 7.95 (d, IH, J=2.1 Hz), 7.52-7.67 (m, 5H), 7.35 (dd, IH, J=2.1, 8.7 Hz), 6.94 (s, IH), 3.60 (q, 2H, J=7.2 Hz), 2.83 (t, 2H, J=7.2 Hz). Analysis calculated for Q20H17CIN4O3S C, 56.00; H, 4.00; N, 13.05 Found: C, 55.74; H, 4.04; N, 13.35 EXAMPLE 38 Preparation of N-(3-methoxybenzyl)-3-phenylsulfonyl-5-chloroindole- 2-carboxamide A solution of dimeric acid chloride (Example 27, Step B) (1.77 g, 2.5 mmol) in dry tetrahydrofuran (25 mL) was added dropwise to a solution of 3-methoxybenzylamine (1.3 mL, 10 mmol) in dry tetrahydrofuran (20 mL) cooled with an ice acetone bath. The reaction was stirred for 12-20 hours and then diluted with 10% methanol/ethyl acetate. This organic layer was washed with dilute HCI, dried (Na2Sθ4), filtered, and the solvents evaporated. The residue was triturated with diethyl ether to give flocculent white product. Recrystallization from hot methanol/ethyl acetate gave analytically pure product, mp 203-204°C. lH NMR (DMSO-c ) δ 9.47 (br t, IH, J=6 Hz), 8.03 (s, IH), 8.01 (s, IH), 7.94 (d, IH, J=2.1 Hz), 7.63 (t, IH, J=6.9 Hz), 7.52-7.58 (m, 3H), 7.35 (dd, IH, J=2.1, 8.7 Hz), 7.29 (t, IH, J=7.8 Hz), 7.06 (s, IH), 7.05 (d, IH, J=6.6 Hz), 6.86 (dd, IH, J=2.7, 7.5 Hz), 4.57 (q, 2H, J=6 Hz), 3.76 (s, 3H). Analysis calculated for C23H 19CIN2O4S C, 60.72; H, 4.21; N, 6.16 Found: C, 60.60; H, 4.17; N, 6.12 EXAMPLE 39. Preparation of N-(3-hydroxybenzyl)-3-phenylsulfonyl-5-chloroindole- 2-carboxamide To a saturated solution of N-(3-methoxybenzyl) 3- phenylsulfonyl-5-chloroindole-2-carboxamide (1.37 g, 3.0 mmol) in dry methylene chloride (140 mL) under an inert atmosphere was added boron tribromide in hexane (1 M, 10 mL, 10 mmol). After stirring for 12-20 hours, the reaction was neutralized by addition of aq. NaHC03. After two hours, the solution was made weakly acidic by addition of dilute HCI. The precipitated product was collected by filtration and then the aqueous filtrate extracted with ethyl acetate. The organic layer was dried (Na2S04), filtered, and the solvent evaporated. The residue was triturated with diethyl ether to give additional product. The solids were combined and crystallized from hot methanol/ethyl acetate to give analytically pure product, mp 273.5-274.5°C. lH NMR (DMSO.d6) δ 9.43 (t, IH, J=6 Hz), 8.01 (s, IH), 7.98 (s, IH), 7.97 (d, IH, J=2.1 Hz), 7.63 (t, IH, J=6 Hz), 7.52-7.58 (m, 3H), 7.35 (dd, IH, J=2, 1, 9 Hz), 7.17 (t, IH, J=7.8 Hz), 6.89 (s, IH), 6.86 (s, IH), 6.84 (s, IH), 6.70 (dd, IH, J=2.1, 8.4 Hz), 4.50 (d, 2H, J==6 Hz). Analysis calculated for C22H17CIN2O4S C, 59.93; H, 3.89; N, 6.36 Found: C, 59.91; H, 3.86; N, 6.51 EXAMPLE 40 Preparation of N-(3-nitrobenzyl)-3-phenylsulfonyl-5-chloroindole-2- carboxamide Using the procedure described in Example 34, except for substituting 3-nitrobenzylamine hydrochloride for 2-aminomethyl- imidazole dihydrochloride and adjusting the amount of triethylamine accordingly, the title compound was obtained, mp 253-254°C. Analysis calculated for C22H 16CIN3O5S C, 56.23; H, 3.43; N, 8.94 Found: C, 55.98; H, 3.37; N, 8.85 EXAMPLE 41 Preparation of N-(3-aminobenzyl)-3 -pheny lsulfonyl-5-chloroindole-2- carboxamide (30) A solution of N-(3-nitrobenzyl) 3-phenyl-sulfonyl-5- chloroindole-2-carboxamide (353 mg, 0.75 mmol) in tetrahydrofuran (25 mL) and methanol (10 mL) containing platinum oxide (70 mg) was hydrogenated with an atmospheric pressure of hydrogen for 3 hours. The degassed solution was filtered to remove catalyst and the solvents evaporated. The residue was triturated with diethyl ether to give the product. Crystallization from acetonitrile gave analytically pure product, mp 247-249°C. lH NMR (DMSO-d6) δ 9.38 (t, IH, J=6 Hz), 7.98 (s, IH), 7.96 (d, IH, J=2.1 Hz), 7.53-7.60 (m, 4H), 7.35 (dd, IH, J=2.1, 9 Hz), 7.02 (t, IH, J=7.5 Hz), 6.61 (s, IH), 6.60 (d, IH, J=6 Hz), 6.50 (dd, IH, J=2.1, 8.1 Hz), 4.43 (d, 2H, J=6 Hz). Analysis calculated for C22H 18C1N3O3S-0.25H2O C, 59.45; H, 4.20; N, 9.46 Found: C, 59.43; H, 4.08; N, 9.54 EXAMPLE 42 Preparation of N-(2-methoxybenzyl)-3-phenylsulfonyl-5-chloroindole- 2-carboxamide Using the procedure described in Example 38, except substituting 2-methoxybenzylamine for 3-methoxybenzylamine, the title compound was obtained, mp 235-237°C. lH NMR (DMSO-d6) δ 9.39 (t, IH, J=6 Hz), 7.99 (d, IH, J=2.1 Hz), 7.95 (s, IH), 7.93 (s, IH), 7.63 (t, IH, J=7.2 Hz), 7.50-7.57 (m, 3H), 7.29-7.44 (m, 3H), 7.06 (d, IH, J=7.5 Hz), 6.97 (dt, IH, J=0.9, 7.2 Hz), 4.55 (d, 2H, J=5.7 Hz), 3.85 (s, 3H). Analysis calculated for C23H 19C1N2O4S-0.2H2O C, 60.24; H, 4.26; N, 6.11 Found: C, 60.19; H, 4.40; N, 6.11 EXAMPLE 43 Preparation of N-(2-hydroxybenzyl)-3-phenylsulfonyl-5-chloroindole- 2-carboxamide Using the procedure described in Example 39, except substituting the 2-methoxy isomer (Example 42) for the 3-methoxy isomer described, the title compound was obtained, mp 243-244.5°C. iH NMR (DMSO-d6) δ 7.99 (d, IH, J=3 Hz), 7.98 (s, IH), 7.97 (s, IH), 7.63 (t, IH, J=6 Hz), 7.51-7.57 (m, 3H), 7.33-7.38 (m, 2H), 7.14 (dt, IH, J=1.2, 7.8 Hz), 6.89 (d, IH, J=7.2 Hz), 6.81 (t, IH, J=7.2 Hz), 4.52 (s, 2H). Analysis calculated for C22H 17C1N2O4S-0.2H2O C, 59.44; H, 3.95; N, 6.30 Found: C, 59.38; H, 3.70; N, 6.39 EXAMPLE 44 Preparation of N-(4-methoxybenzyl)-3-phenylsulfonyl-5-chloroindole- 2-carboxamide Using the procedure described in Example 38, except substituting 4-methoxybenzylamine for 3-methoxybenzylamine, the title compound was obtained, mp 205-206°C. iH NMR (DMSO-d6) δ 9.42 (br t, IH, J=6 Hz), 8.01 (s, IH), 7.98 (s, IH), 7.95 (d, IH, J=1.8 Hz), 7.64 (t, IH, J=7.2 Hz), 7.52-7.58 (m, 3H), 7.33-7.40 (m, 3H), 6.95 (d, 2H, J=9 Hz), 4.51 (d, 2H, J=6 Hz), 3.76 (s, 3H). Analysis calculated for C23H 19CIN2O4S C, 60.72; H, 4.21; N, 6.16 Found: C, 60.59; H, 4.14; N, 6.11 EXAMPLE 45 Preparation of N-(4-hydroxybenzyl)-3-phenylsulfonyl-5-chloroindole- 2-carboxamide Using the procedure described in Example, 39, except substituting the 4-methoxy isomer (Example 44) for the methoxy isomer described, the title compound was obtained, mp 249-250°C. iH NMR (DMSO-d6) δ 9.35 (t, IH, J=6 Hz), 7.95-7.99 (m, 3H), 7.62 0 (t, IH, J=6.9 Hz), 7.52-7.57 (m, 3H), 7.35 (dd, IH, J=1.8, 8.7 Hz), 7.25 (d, 2H, J=8.7 Hz), 6.76 (d, 2H, J=8.1 Hz), 4.46 (d, 2H, J=6 Hz). Analysis calculated for C22H17CIN2O4S C, 59.93; H, 3.89; N, 6.36 Found: C, 59.37; H, 3.85; N, 6.25 5 EXAMPLE 46 Preparation of N-(3-acetylaminobenzyl)-3-phenyl-sulfonyl-5-chloro- indole-2-carboxamide A solution of N-(3-aminobenzyl) 3-phenyl-sulfonyl-5- 0 chloroindole-2-carboxamide (Example 41) (176 mg, 0.4 mmol) in dry tetrahydrofuran (7 mL) containing acetic anhydride (0.05 mL, 0.5 mmol) was stirred at room temperature for 16 hours. The reaction was diluted with water and extracted with ethyl acetate. The organic layer was dried (Na2Sθ4), filtered through charcoal, and the solvents 5 evaporated. The residue was triturated with methylene chloride and the solid collected by filtration to give the product, mp 249-250°C. iH NMR (DMSO-d6) δ 9.98 (br s, IH), 9.39 (v br s, IH), 7.96-8.00 (m, 3H), 7.51-7.62 (m, 6H), 7.30 (t, 2H, J=8 Hz), 7.14 (d, IH, J=8 Hz), 4.53 (br s, 2H), 2.04 (s, 3H). o Analysis calculated for C24H20CIN3O4S C, 59.81; H, 4.18; N, 8.72 . Found: C, 59.41; H, 4.09; N, 8.62 EXAMPLE 47 Preparation of N-(3-methylsulfonylammobenzyl)-3-phenyl-sulfonyl-5- chloroindole-2-carboxamide (34) To a solution of N-(3-aminobenzyl) 3-phenyl-sϋlfonyl-5- chloroindole-2-carboxamide (174 mg, 0.4 mmol) in dry tetrahydro¬ furan (7 mL) at room temperature under an inert atmosphere was added methanesulfonyl chloride (.035 mL, .45 mmol) and triethylamine (0.7 mL, .50 mmol). Over a period of 20 hours, the reaction progress was momtored by tic. Additional equivalents of methanesulfonyl chloride and triethylamine were added twice over this period to obtain complete reaction with the carboxamide. The reaction was diluted with water, acidified with dilute HCI, and the product extracted into chloroform. This organic layer was dried (Na2Sθ4), filtered, and the solvent evaporated. The residue was purified by chromatography on silica gel. Elution with 1% methanol/chloroform gave the bis-sulfonylated product as evidenced by two methyl group resonances in the NMR at δ 3.47 and 2.98. This material was dissolved in dimethoxyether (3 mL) and water (2 mL) and lithium hydroxide monohydrate (66 mg, 1.57 mmol) was added. The solution was heated at 60°C for two hours. The cooled reaction was acidified with dilute HCI. Upon stirring for 2-3 hours, the product crystallized out and was collected by filtration and dried. Recrystallization from hot methanol/ethyl acetate gave analytically pure product, mp 252-253°C. iH NMR (DMSO-d6) δ 9.48 (br t, IH, J=5.4 Hz), 8.01 (s, IH), 7.98 (s, IH), 7.95 (d, IH, J=1.8 Hz), 7.63 (t, IH, J=7.2 Hz), 7.52-7.58 (m, 3H), 7.33-7.38 (m, 2H), 7.27 (br s, IH), 7.23 (br d, IH, J=7.8 Hz), 7.15 (d, IH, J=7.8 Hz), 4.55 (d, 2H, J=5.4 Hz), 3.00 (S, 3H). Analysis calculated for C23H20CIN3O5S2 C, 53.33; H, 3.89; N, 8.11 Found: C, 53.26; H, 3.86; N, 8.12 EXAMPLE 48 Preparation of N-benzyl-3-phenylsulfonyl-5-chloroindole-2- carboxamide A solution of the dimeric acid chloride (Example 27, Step B) (170 mg, 0.25 mmol) in dry tetrahydrofuran (2 mL) was added dropwise to a solution of benzylamine (.28 mL, 2.5 mmol) in dry tetrahydrofuran (3 mL) cooled in an ice/acetone bath. The reaction mixture was left to stir for 12-20 hours as the temperature rose to ambient. The solvents were removed under vacuum and the residue partitioned between ethyl acetate and water. The ethyl acetate layer was washed with brine, dried (Na2Sθ4), and the solvent evaporated. The residue was crystallized from ethyl acetate/methanol to give analytically pure product, mp 249-251°C. iH NMR (DMSO-d6) δ 9.47 (t, IH, J=6 Hz), 8.02 (s, IH), 8.00 (s, IH), 7.95 (d, IH, J=2.1 Hz), 7.33-7.57 (m, 10 H), 4.59 (d, 2H, J=6 Hz). Analysis calculated for C22H 17CIN2O3 S C, 62.19; H, 4.03; N, 6.59 Found: C, 62.14; H, 4.13; N, 6.62 EXAMPLE 49 Preparation of N-(3-pyridylmethyl)-3-phenylsulfonyl-5-chloroindole- 2-carboxamide (28) Using the procedure in Example 48, except substituting 3- aminomethylpyridine for benzylamine, the title compound was obtained, mp 263-264°C. Analysis calculated for C21 H 16CIN3O3 S C, 59.22; H, 3.79; N, 9.87 Found: C, 59.01; H, 3.79; N, 9.87 EXAMPLE 50 Preparation of N-(2-pyridylmethyl)-3-phenylsulfonyl-5-chloroindole- 2-carboxamide Using the procedure described in Example 48, except substituting 2-aminomethylpyridine for benzylamine, the title compound was obtained, mp 250-251°C. Analysis calculated for C21H16CIN3O3S C, 59.22; H, 3.79; N, 9.87 Found: C, 59.04; H, 3.73; N, 10.06 EXAMPLE 51 Preparation of N-[2-(pyridin-4-yl)ethyl]-3-phenyl-sulfonyl-5- chloroindole-2-carboxamide Using the procedure described in Example 48, except substituting 4-(2-aminoethyl)pyridine for benzylamine, the title compound was obtained, mp 258-260°C. Analysis calculated for C22H 18CIN3O3 S C, 60.07; H, 4.12; N, 9.55 Found: C, 59.68; H, 3.84; N, 9.30 EXAMPLE 52 Preparation of N-(2-hydroxyethyl)-3 -pheny Isulfony 1-5 -chloroindole-2- carboxamide Using the procedure described in Example 48, except substituting 2-hydroxyemylamine for benzylamine, the title compound was obtained, mp 198-200°C. Analysis calculated for C 17H 15CIN2O4S C, 53.90; H, 3.99; N, 7.39 Found: C, 54.09; H, 3.94; N, 7.25 EXAMPLE 53 Preparation of N-ethyl-3-phenylsulfonyl-5-chloroindole-2-carboxamide Using the procedure described in Example 48, except substituting emylamine for benzylamine, the title compound was obtained, mp 259-260°C. Analysis calculated for C 17H \ 5CIN2O3 S C, 56.28; H, 4.17; N, 7.72 Found: C, 56.07; H, 4.11; N, 7.73 EXAMPLE 54 Preparation of N-[(2-chloropyridin-4-yl)methyl] -3-phenylsulf onyl-5 - chloroindole-2-carboxamide Using the procedure described in Example 35, Step B, except substituting 2-chloro-4-aminomethyl-pyridine for 2- aminomethyl-1-methylimidazole, the title compound was obtained, mp 263-265°C. Analysis calculated for C21H15CI2N3O3S C, 54.79; H, 3.28; N, 9.13 Found: C, 54.38; H, 3.18; N, 9.03 EXAMPLE 55 Preparation of N-cyclopropyl-5-chloro-3-phenylsulfonyl-indole-2- carboxamide (26) Using the procedure described in Example 48, except substituting cyclopropylamine for benzylamine, the title compound was obtained, mp 242-243°C. Analysis calculated for C 1 H 15CIN2O3 S C, 57.68; H, 4.03; N, 7.47 Found: C, 57.40; H, 3.94; N, 7.43 EXAMPLE 56 Preparation of N-(cyclopropylmethyl)-3-phenylsulfonyl-5-chloroindole- 2-carboxamide Using the procedure described in Example 48, except substituting cyclopropylmethylamine for benzylamine, the title compound was obtained, mp 232-234°C. Analysis calculated for C\ 9H17CIN2O3S C, 57.88; H, 4.50; N, 7.11 Found: C, 57.92; H, 4.34; N, 7.09 EXAMPLE 57 Preparation of 3-(4-chlorophenylsulfonyl)-5-chloro-indole-2- carboxamide Using the procedure described in Example 30 and 31, except substituting bis(4-chlorophenyl)disulfide for di(2-thiazolyl)- disulfide, the title compound was obtained, mp 275-277°C. Analysis calculated for C 15H 10CI2N2O3S C, 48.32; H, 2.81; N, 7.51 Found: C, 48.23; H, 2.84; N, 7.91 EXAMPLE 58 Preparation of 3-(3-chlorophenylsulfonyl)-5-chloro-indole-2- carboxamide Using the procedure described in Example 30 and 31, except substituting bis(3-chlorophenyl)disulfide for di(2-thiazolyl)- disulfide, the title compound was obtained, mp 272-273°C. Analysis calculated for C15H1 (3CI2N2O3S C, 48.79; H, 2.73; N, 7.59 Found: C, 48.39; H, 2.70; N, 7.44 EXAMPLE 59 Preparation of 3-(3,5-dichlorophenylsulfonyl)-5-chloro-indole-2- carboxamide Using the procedure described in Example 30 and 31, except substituting bis(3,5-dichlorophenyl)-disulfide for di(2-thiazolyl)- disulfide, the title compound was obtained, mp 258-260°C. Analysis calculated for C \ 5H9CI3N2O3S C, 44.63; H, 2.25; N, 6.94 Found: C, 44.49; H, 2.24; N, 7.04 EXAMPLE 60 Preparation of 3-(2-chlorophenylsulfonyl)-5-chloro-indole-2- carboxamide Using the procedure described in Example 33, except substituting 2-chlorothiophenol for thiophenol, the title compound was obtained, mp 267°C. Analysis calculated for C 15H 10CI2N2O3S C, 48.79; H, 2.73; N, 7.59 Found: C, 48.69; H, 2.73; N, 7.62 EXAMPLE 61 Preparation of 3-(pyridin-2-ylsulfonyl)-5-chloroindole-2-carboxamide Using the procedure described in Example 30 and 31, except substituting bis(pyridin-2-yl)disulfide for di(2-thiazolyl)- disulfide, the title compound was obtained, mp 244-246°C. Analysis calculated for C14H10CIN3O3S C, 50.08; H, 3.00; N, 12.51 Found: C, 50.31; H, 3.00; N, 12.55 EXAMPLE 62 Preparation of 3-(pyridin-3-ylsulfonyl)-5-chloroindole-2-carboxamide Using the procedure described in Example 30 and 31, except substituting bis(pyridin-3-yl)disulfide for di(2-thiazolyl)- disulfide, the title compound was obtained, mp 300°C dec. FAB mass spectrum: m/e = 336 (M+l) EXAMPLE 63 Preparation of 3-(pyridin-4-ylsulfonyl)-5-chloroindole-2-carboxamide Using the procedure described in Example 30 and 31, except substituting bis(pyridin-4-yl)disulfide for di(2-thiazolyl)- disulfide, the title compound was obtained, mp>260°C dec. FAB mass spectrum: m/e = 336 (M+l) EXAMPLE 64 Preparation of 3-[(l-methylimidazol-2-yl)sulfonyl]-5-chloroindole-2- carboxamide Using the procedure described in Example 30 and 31, except substituting bis(l-methylimidazol-2-yl)-disulfide for di(2- thiazolyl)disulfide, the title compound was obtained, mp 255-256°C dec. Analysis calculated f or C 13H 11 CIN4O3 S C, 46.09; H, 3.27; N, 16.54 Found: C, 46.02; H, 3.28; N, 16.27 EXAMPLE 65 Preparation of N-(3-methoxybenzyl-3-(3-chlorophenylsulfonyl)-5- chloroindole-2-carboxamide Using the procedure described in Example 38, except substituting the dimeric acid chloride derived from 3-(3- chlorophenylsulfonyl)-5-chloroindole-2-carboxylic acid for that derived from 3-(phenyl-sulfonyl)-5-chloroindole-2-carboxylic acid, the title compound was obtained, mp 225-226.5°C. Analysis calculated for C23H 18CI2N2O4S C, 56.45; H, 3.71; N, 5.73 Found: C, 56.52; H, 3.70; N, 5.83 EXAMPLE 66 Preparation of N-(3-hydroxybeιιzyl)-3-(3-chlorophenylsulfonyl)-5- chloroindole-2-carboxamide Using the procedure described in Example 39, N-(3- methoxybenzyl)-3-(3-chlorophenylsulfonyl)-5-chloroindole-2- carboxamide was demethylated to obtain the title compound, mp 230- 231°C. Analysis calculated for C22H 16CI2N2O4S C, 55.58; H, 3.39; N, 5.89 Found: C, 55.59; H, 3.36; N, 5.66 EXAMPLE 67 Preparation of N-[(l-methylimidazol-2-yl)methyl]-3-(3-chloro- phenylsulfonyl)-5-chloroindole-2-carboxamide (23) Using the procedure described in Example 35, except for substituting the dimeric acid chloride derived from 3-(3-chlorophenyl- sulfonyl)-5-chloroindole-2-carboxylic acid for that derived from 3- (phenylsulfonyl)-5-chloroindole-2-carboxylic acid, the title compound was obtained, mp 232-234°C. Analysis calculated for C20H 16CI2N4O3S C, 51.84; H, 3.48; N, 12.09 Found: C, 51.46; H, 3.38; N, 11.78 EXAMPLE 68 Preparation of 2-carboxamido-5-chloroindole-3-cyclo-propyl- sulfonamide Step A: 2-Carboethoxy-5-chloro- 1 -phenylsulfonylindole-3- sulfonic acid Concentrated sulfuric acid (2.50 ml, 90 mmol) was added, dropwise over 5 min at 0°C to a stirred solution of 2-carboethoxy-5- chloro-1-phenylsulfonylindole (7.28 g, 20.0 mmol) in acetic anhydride (10 ml) and dry dichloromethane (50 ml). The resulting tan solution was warmed to RT (room temperature) and after 3 hours was poured onto ice and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with brine, dried (Na2Sθ4) and evaporated in vacuo to a syrup. Residual acetic anhydride was removed by azeotroping with toluene (3 x 50 ml), and the residue was crystallized from dichloromethane. The dichloromethane was evaporated in vacuo to give the title compound as a tan powder: iH NMR (d6 DMSO) δ 1.33 (t, J=7.1 Hz, 3H), 4.33 (q, J=7.1 Hz, 2H), 7.44 (dd, J=8.9 and 2.2 Hz, IH), 7.63 (t, J=7.6 Hz, 2H), 7.73 (t, J=7.4 Hz, IH), 7.77 (d, J=2.2 Hz, IH), 7.96 (d, J=8.9 Hz, IH), 8.00 (d, J=7.6 Hz, 2H). Step B: 2-Carboethoxy-5-chloro-l -phenylsulfonyl-indole-3- cyclopropylsulfonamide Oxalyl chloride (0.90 ml, 10.3 mmol) was added to a stirred solution of 2-carboethoxy-5-chloro-l-phenylsulfonylindole-3- sulfonic acid (1.505 g, 3.39 mmol) in dry dichloromethane (15 ml) at 0°C. DMF (2 drops) was added and the solution was warmed to room temperature. More DMF (1 drop) was added and the reaction was heated to reflux. After 2 hours, the solution was cooled and evaporated in vacuo to give the sulfonylchloride as a tan solid. This was dissolved in dichloromethane (15 ml) and cyclopropylamine (0.94 ml, 13.56 mmol) and pyridine (0.5 ml) were added. The solution was heated to reflux and after 15 min was cooled, diluted with ethyl acetate and was washed with 1 M HCI solution, sodium hydrogen carbonate solution and brine, dried (Na2S04) and evaporated in vacuo to a gum. Methanol (5 ml) was added to give a colorless solid, and the mixture was stirred and heated to reflux for 5 min. The solids were filtered cold, washing with cold methanol (3x5 ml), and were dried in vacuo to give the title compound as colorless crystals: mp 189-191°C; iH NMR (CDCI3) δ 0.61 (m, 4H), 1.48 (t, J=7.1 Hz, 3H), 2.26 (m, IH), 4.58 (q, J=7.1 Hz, 2H), 5.06 (br s, IH), 7.42 (dd, J=9.0 and 2.0 Hz, IH), 7.54 (t, J=7.6 Hz, 2H), 7.66 (t, J=7.5 Hz, IH), 7.97 (d, J=9.0 Hz, IH), 7.98 (d, J=2.0 Hz, IH), 8.09 (d, J=7.6 Hz, 2H). Step C: 2-Carboxamido-5-chloroindole-3-cvclopropyl-sulfonamide A mixture of 2-carboethoxy-5-chloro-l-phenyl-sulfonyl- indole-3-cyclopropylsulfonamide (0.42 g, 0.870 mmol) and 2:1:1 10% potassium hydroxide solution/methanol/THF (20 ml) was heated to reflux to give a clear tan solution. After 0.5 hour reflux the solution was cooled and was concentrated in vacuo to 1/2 volume. The solution was acidified with 1 M HCI, and the resulting mixture was extracted with ethyl acetate, washed with brine, dried (Na2S04) and evaporated in vacuo to a gum. The crude product was dissolved in 2% sodium hydroxide solution which was acidified with 1 M HCI. The solid material was collected by filtration, washed with 1 M HCI solution, and dried in vacuo to give 3-cyclopropylsulfonamido-5-chloroindole-2- carboxylic acid. Oxalyl chloride (0.58 ml, 6.65 mmol) and DMF (1 drop) were added to a stirred suspension of the acid in dry dichloromethane (10 ml). After 1 hour at room temperature the mixture was heated to reflux for 1 hour, cooled and evaporated in vacuo to a tan solid. The solid was suspended in acetone (10 ml) and 9:1 ammonium hydroxide/acetone solution (20 ml) was added. After 15 min the solution was evaporated in vacuo to 2 ml in volume and the residue was acidified with 1 M HCI solution and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with sodium hydrogen carbonate solution, dried (Na2S04) and evaporated in vacuo. The resulting tan solid was purified by flash chromatography on silica (dry loaded, eluting with a chloroform/methanol gradient, 2-10% methanol), to give the title compound as colorless crystals (from ethyl acetate/hexanes): mp 236-238°C; iH NMR (d6 DMSO) δ 0.40 (m, 4H), 2.07 (m, IH), 7.35 (dd, J=8.7 and 2.1 Hz, IH), 7.56 (d, J=8.7 Hz, IH), 8.01 (d, J=1.7 Hz, IH), 8.10 (d, J=2.1 Hz, IH), 8.22 (br s, IH), 8.47 (br s, IH). EXAMPLE 69 Preparation of 2-carboxamido-5-chloroindole-3-phenyl-sulfonamide Step A: 2-Carboethoxy-5-chloro- 1 -pheny lsulf onylindole-3- phenylsulfonamide In the manner outlined in Example 68, Step B, aniline (0.63 ml, 6.91 mmol) was added to 2-carboethoxy-5-chloro-l-phenyl- sulfonylindole-3-sulfonylchloride to give, after flash column chromatography on silica (dry loaded, eluting with an ethyl acetate/hexanes gradient, 20-30% ethyl acetate) the title compound as colorless crystals; iH NMR (CDCI3) δ 1.47 (t, J=7.1 Hz, 3H), 4.58 (q, J=7.1 Hz, 2H), 6.74 (br s, IH), 7.11 (m, 5H), 7.31 (dd, J=9.0 and 2.2 Hz, IH), 7.51 (t, J=8.1 Hz, 2H), 7.57 (d, J=1.7 Hz, IH), 7.65 (t, J=7.5 Hz, IH), 7.87 (d, J=9.0 Hz, IH), 7.99 (d, J=7.6 Hz, 2H). Step B: 5-Chloro-3-ρhenylsulfonamidoindole-2-carboxylic acid 2-Carboethoxy-5-chloro- 1 -phenylsulf onylindole-3- phenylsulfonamide (0.39 g, 0.75 mmol) was dissolved in 2:1:1 10% sodium hydroxide solution/methanol/THF (20 ml) and after 2 hours the solution was acidified with 1 M HCI, and the resulting mixture was extracted with ethyl acetate, washed with brine, dried (Na2Sθ4) and evaporated in vacuo to a glass. Dichloromethane (5 ml) was added to give a colorless solid, and the mixture was stirred and heated to reflux for 5 min. The solids were filtered cold, washing with cold dichloro- methane, and were dried in vacuo to give the title compound as colorless crystals; iH NMR (d6 DMSO) δ 7.28 (t, J=7.1 Hz, IH), 7.4 (d, J=7.2 Hz, 2H), 7.51 (t, J=7.1 Hz, 2H), 7.72 (dd, J=8.8 and 2.1 Hz, IH), 7.86 (d, J=8.8 Hz, IH), 8.43 (d, J=2.1 Hz, IH), 10.25 (br s, IH). Step C: 2-Carboxamido-5-chloroindole-3-phenyl-sulfonamide Oxalyl chloride (0.087 ml, 1.00 mmol) and DMF (1 drop) were added to a stirred solution of 5-chloro-3-phenylsulfonamido- indole-2-carboxylic acid (123 mg, 0.35 mmol) in dry THF (3 ml) at 0°C. After 1 hour at room temperature the solution was evaporated in vacuo to give a tan solid. The solid was dissolved in acetone (1 ml) and 9:1 ammonium hydroxide/acetone solution (2 ml) was added. After 0.5 hours the solution was evaporated in vacuo to a gum which was dissolved in ethyl acetate, washed with 1 M HCI and brine, dried (Na2Sθ4) and evaporated in vacuo. The resulting tan solid was purified by flash column chromatography on silica (dry loaded, eluting with an ethyl acetate/hexanes gradient, 20-70% ethyl acetate) to give the title compound as colorless crystals (from dichloromethane); mp 225-227°C: iH NMR (d6 DMSO) δ 7.00 (m, 3H), 7.17 (t, J=7.3 Hz, 2H), 7.30 (dd, J=8.8 and 2.0 Hz, IH), 7.48 (d, J=8.8 Hz, IH), 7.93 (d, J=2.0 Hz, IH), 8.21 (br s, IH), 8.28 (br s, IH), 10.34 (br s, IH). EXAMPLE 70 Preparation of 2-carboxamido-5-chloroindole-3-methyl-(phenyl)- sulfon-amide Step A: 2-Carboethoxy-5-chloro- 1 -phenylsulf onylindole-3- methyKphenyPsulfonamide In the manner outlined in Example 68, Step B, N-methyl- aniline was added to 2-carboethoxy-5-chloro-l-phenyl-sulfonylindole-3- sulfonylchloride to give, after flash column chromatography on silica (dry loaded, eluting with an ethyl acetate/hexanes gradient, 10-30% ethyl acetate) the title compound as colorless crystals (from dichloromethane/hexanes); iH NMR (CDCI3) δ 1.46 (t, J=7.1 Hz, 3H), 3.30 (s, 3H), 4.55 (q, J=7.1 Hz, 2H), 6.69 (d, J=2.0 Hz, IH), 7.11 (d, J=7.0 Hz, 2H), 7.26 (m, 4H), 7.54 (t 5i J=7.6 Hz, 2H), 7.66 (t, J=7.4 Hz, IH), 7.87 (d, J=8.8 Hz, IH), 8.08 (d, J=7.6 Hz, 2H). Step B: 5-Chloro-3-methyl(phenyl)sulfonamidoindole-2- carboxylic acid In the manner outlined in Example 69, Step B, 2- carboethoxy-5-chloro- 1 -phenylsulfonylindole-3-methyl-(phenyl)- sulfonamide (0.39 g, 0.75 mmol) was hydrolysed in 2:1:1 10% sodium hydroxide solution/methanol/THF (20 ml, 14 h at RT (room temperature) followed by 5 min at reflux), to give the title compound (from ethyl acetate); iH NMR (d6 DMSO) δ 3.26 (s, 3H), 7.03 (d, J=2.2 Hz, IH), 7.21 (m, 6H), 7.46 (d, J=8.8 Hz, IH). Step C: 2-Carboxamido-5-chloroindole-3-methyl(phenyl)- sulfonamide In the manner outlined in Example 69, Step C, starting with 5-chloro-3-methyl(phenyl)sulfonamidoindole-2-carboxylic acid, and after purification by flash column chromatography on silica (dry loaded, eluting with 2% methanol/chloroform), the title compound was obtained as colorless crystals (from ethyl acetate); mp 240-242°C. iH NMR (d6 DMSO) δ 3.13 (s, 3H), 7.06 (d, J=2.1 Hz, IH), 7.09 (m, 2H), 7.23 (dd, J=8.8 and 2.1 Hz, IH), 7.26 (m, 3H), 7.48 (d, J=8.8 Hz, IH), 8.01 (br s, IH), 8.06 (br s, IH). EXAMPLE 71 Preparation of N-[2-(l-memylimidazol-4-yl)emyl]-3-phenylsulfonyl- 5-chloroindole-2-carboxamide (25) Reaction of 3-phenylsulfonyl-5-chloroindole-2-carboxylic acid with 1-methylhistamine under the conditions of Example 37 provides the title compound. EXAMPLE 72 Preparation of N-[2-(3-memylimidazol-4-yl)emyl]-3-phenylsulfonyl- 5-chloroindole-2-carboxamide Reaction of 3-phenylsulfonyl-5-chloroindole-2-carboxylic acid with 3-methylhistamine under the conditions of Example 37 gave the title compound, mp 257-258.5°C. EXAMPLE 73 Preparation of N-[(imidazol-4-yl)memyl]-3-phenylsulfonyl-5- chloroindole-2-carboxamide Reaction of the dimeric acid chloride (Example 27, Step B) with 4-aminomethylimidazole under the conditions of Example 34 provides the title compound. EXAMPLE 74 Preparation of N-[3-(imidazol-l-yl)propyl]-3-phenylsulfonyl-5- chloroindole-2-carboxamide Reaction of the 3-phenylsulfonyl-5-chloroindole-2- carboxylic acid with l-(3-aminopropyl)-imidazole under the conditions of Example 37 gave the title compound, mp 216-217.5°C. EXAMPLE 75 Preparation of 3-phenylsulfonyl-5-memylsulfonylamino-indole-2- carboxamide (36) Step A: 3-Phenylsulfonyl-5-nitroindole-2-carboxamide Reaction of ethyl 5-nitroindole-2-carboxylate (J. Amer. Chem. Soc. 80. 4621 (1958)) with N-( henyl-mio)succinimide under the conditions of Example 33, Step B, followed by oxidation to the sulfonyl product (Step C) provides a product which may be converted to the title compound with ammonium hydroxide at elevated temperature and pressure. Step B: 3-Phenylsulfonyl-5-aminoindole-2-carboxamide Reduction of 3-phenylsulfonyl-5-nitroindole-2-carbox- amide with hydrogen under the conditions of Example 41 provides the title compound. Step C: 3-Phenylsulfonyl-5-methylsulfonylaminoindole-2- carboxamide Reaction of 3-phenylsulfonyl-5-aminoindole-2-carboxamide with methanesulfonyl chloride under the conditions of Example 47 provides the title compound. EXAMPLE 76 Preparation of 4-[(5-chloro-3-phenylsulfonylindole-2-carboxamido)- methvnpyridin-2(lH)-one (37) Step A: N-(2-methoxy-4-pyridylmethyl)-5-chloro-3-phenyl- sulfonylindole-2-carboxamide Reaction of the 'acid chloride dimer' product of Example 27, Step B, with 2-methoxy-4-pyridylmethylamine under the conditions of Example 27, Step C, provides the title compound. Step B: 4-[(5-CMoro-3-phenylsulfonylindole-2-carboxamido)- methyll -pyridin-2( 1 H)-one Reaction of N-(2-methoxy-4-pyridylmethyl)-5-chloro-3- phenylsulfonylindole-2-carboxamide with boron tribromide in methylene chloride at 0°C to room temperature, according to the procedure described in Example 39, provides the title compound. EXAMPLE 77 Preparation of N-(2-ammo-4-pyridylmethyl)-5-chloro-3-phenyl- sulfonylindole-2-carboxamide (38) Step A: 2-Amino-4-aminomethylpyridine 2-Aminopyridine-4-carbonitrile (L.W. Deady et al., Aust. J. Chem.. 35. 2025 (1982)) is reduced catalytically according to the procedure of D.E. Beattie si al- for the preparation of 2-amino-3- aminomethyl pyridine (J. Med. Chem.. 20, 718, (1977)) to give the title compound. Step B: N-(2-Amino-4-pyridylmethyl)-5-chloro-3-phenylsulfonyl- indole-2-carboxamide Reaction of 2-ammo-4-aminomethylpyridine with the dimeric acid chloride from Example 27, Step B, according to the procedure of Example 27, Step C, provides the title compound. EXAMPLE 78 Preparation of N-(2-am othiazol-4-ylmethyl)-5-chloro-3-phenyl- sulfonyl-indole-2-carboxamide Reaction of the dimeric acid chloride from Example 27, Step B, with 2-aminothiazol-4-ylmethylamine (Chem. Ab. 58, 4534 (1962)) under the conditions of Example 27, Step C, provides the title compound. EXAMPLE 79 Preparation of N-cyano-5-chloro-3-phenylsulfonylindole-2-carbox- imid-amide (35) Step A: 5-Chloro-3-phenylsulfonylindole-2-carbonitrile 5-Chloro-3-phenylsulfonylindole-2-carboxamide reacts with methyl (carboxysulfamoyl)triethylammonium hydroxide inner salt (Burgess reagent) in tetrahydrofuran (THF) solvent as described by D.A. Claremon and B.T. Phillips (Tetrahedron Lett..22, 2155 (1988)) to provide the title compound. Step B: Ethyl 5-chloro-3-phenylsulfonylindole-2-carboximidate 5-Chloro-3-phenylsulfonylindole-2-carbonitrileis allowed to react with ethanol saturated with hydrogen chloride at 0-10°C for 7 days. Evaporation to dryness affords the title compound as a hydrochloride salt. The title compound is obtained as a free base by adding the reaction mixture to an ice cold solution of excess potassium carbonate and extracting the product with chloroform. Step C: N-Cyano-5-chloro-3-phenylsulfonylindole-2-carboximid- amide Ethyl 5-chloro-3-phenylsulfonylindole-2-carboximidate is reacted with an equimolar amount of cyanamide in absolute methanol (according to the procedure of K.R. Huffman and F.C. Schaefer (J. Org. Chem.. 28, 1812 (1963)). After 30-60 minutes the solvent is removed and the residue purified by silica gel chromatography to afford the title compound. EXAMPLE 80 Preparation of N-cyclobutyl-5-chloro-3-phenylsulfonylindole-2- carboxamide (27) Using the procedure of Example 48 but substituting cyclobutylamine for benzylamine, there is obtained the title compound. EXAMPLE 81 Preparation of N-cyclopropyl-5-chloro-3-phenylsulfinylindole-2- carboxamide (39) Using the procedure of Example 28, Step B, but substituting cyclopropylamine for 4-aminomethylpyridine, there is obtained the title compound. EXAMPLE 82 Preparation of N-[(l-me ylimidazol-2-yl)memyl]-3-phenylsulfinyl-5- chloroindole-2-carboxamide (20) Using the procedure of Example 28, Step B, but substituting 2-aminomethyl-l -methy limidazole for 4-aminomethyl- pyridine, there is obtained the title compound. EXAMPLE 83 Preparation of N-[(l-methylimidazol-4-yl)methyl-3-phenylsulfonyl-5- chloroindole-2-carboxamide (21) and N-[(l-methylimidazol-5- yl)methyll-3-phenylsulfonyl-5-chloroindole-2-carboxamide (22) Step A: N-[(Imidazol-4(or 5)-ylmethyl]-3-phenylsulfonyl-5- chloroindole-2-carboxamide Employing the procedure of Example 34, but substituting 4(or 5)-aminomethylimidazole dihydrochloride for 2-aminomethyl- imidazole dihydrochloride, there is obtained the title compound. Step B: N-[(l -methylimidazol-4-yl)methyl]-3-phenylsulfonylindole- 5-chloroindole-2-carboxamide; N-[(l -methy limidazol-5- yl)methyll-3-phenylsulfonyl-5-chloroindole-2-carboxamide Employing the procedure of Example 36, but substituting N-[(imidazol-4(or 5)-yl)methyl]-3-phenylsulfonyl-5-chloroindole-2- carboxamide for N-[(imidazol-2-yl)methyl]-3-phenylsulfonyl-5- chloroindole-2-carboxamide, there is obtained each of the title compounds which are obtained pure by chromatography on silica gel. 0 EXAMPLE 84 Preparation of N-[(R)-l-phenylethyl]-5-chloro-3-phenylsulfonyl- indole-2-carboxamide (33) ; 5 Employing the procedure of Example 29, but substituting (R)-(+)-a-methylbenzylamine for (S)-(+)-2-ρhenylglycinol, there was obtained the title compound, mp 149°C. Analysis calculated for C23H19C1N2O3S-0.15 C2H4O2O.I5H2O C, 62.32; H, 4.54; N, 6.16 o Found: C, 62.39; H, 4.54; N, 6.01 iH NMR (DMSO-d6) δ 3.06 (IH, s); 9.43 (IH, d, J=8Hz); 7.94-8.02 (3H, m); 7.46-7.67 (6H, m); 7.25-7.42 (4H, m); 5.21 (IH, q,J =7Hz); 1.53 (3H, d, J=7Hz). 5 EXAMPLE 85 Preparation of N-[(l-emyliπndazol-2-yl)memyl]-3-phenylsulfonyl-5- chloroindole-2-carboxamide Using the procedure described in Example 35, except ° substituting 2-aminomethy 1- 1 -ethy limidazole for the 2-aminomethy 1- 1 - methylimidazole (Step A), the title compound was obtained, mp 204- 205.5°C. While the foregoing specification teaches the principles of the present invention, with examples provided for the purpose of illustration, it will be understood that the practice of the invention encompasses all of the usual variations, adaptations, and modifications, as come within the scope of the following claims and its equivalents.

Claims: WHAT IS CLAIMED IS: 1. A compound of formula A, wherein X is -H, -Cl, -F, -Br, -N0 2 , -CN, -OR2, -NR2R2, -NHSO2- Cι_3alkyl, or -NHCO-Cι _3alkyl; Y is -S(0) n - or -0-, wherein n is zero, 1 or 2; R is 1) -Cι _5alkyl, unsubstituted or substituted with one or more of: a) -Cι_5alkyl, b) -Cι _5alkoxy, c) -OH, or d) aryl, unsubstituted or substituted with one or more of: i) -Cι . 5 alkyl, ii) -Cι_5alkoxy, iii) -OH, iv) halogen, or v) -NR2R2, 2) aryl, unsubstituted or substituted with one or more of: a) -Ci _5alkyl, unsubstituted or substituted with one or more of: i) -OH or ii) -Cι_5alkoxy, b) -Cι _5alkoxy, c) -OH, d) halogen, or e) -NR2R2, 3) heterocycle, unsubstituted or substituted with one or more of: a) -Cι_5alkyl, unsubstituted or substituted with one or more of? i) -OH or ii) -Cι_5alkoxy, b) -Cι_5alkoxy, c) -OH, d) halogen, or e) -N 2R2, or 4) -NR2R3, provided that Y is -S(0) n -; Z is wherein W is O, S, -N-CN, or -N-OR 2 , 3) -COORlb, 4) -CR2R2-S(0) n -Rla, wherein n is defined above, 5) -CR2R2NHR4, 6) -CR2R2-CO-R5, 7) -Ci-3 alkyl substituted with one or more of: a) aryl, unsubstituted or substituted with one or more of: v) -NR2R2, or 3) aryl, unsubstituted or substituted with one or more of: a) -Ci _5alkyl, unsubstituted or substituted with one or , more of: i) -OH or ii) -Cι_5alkoxy, b) -Cι _5alkoxy, c) -OH, d) halogen, e) -CN, f) -Nθ2, or g) -NR2R2 ; or 4) heterocycle, unsubstituted or substituted with one or more of: a) -Cι_5alkyl, unsubstituted or substituted with one or more of: i) -OH or ii) -Cι_5alkoxy, a) -Cι_5alkoxy, 2) 3) ix) -NHCO-Cι_3alkyl, or x) -NHSθ2-Cι_3alkyl, h) -NR2R2, i) -C3_6cycloalkyl, R? is 15 1) aryl, unsubstituted or substituted with one or more of -Cl, -Br, -OH, -OCH3, or -CN, or 2) -Cι _5alkyl, unsubstituted or substituted with one or more of -OH or -NR2R2 ; and 20 with the proviso that when X is -H, Y is -S, R is unsubstituted phenyl and R 6 is -H, Z is not -CH2-SO-Ph, -COH, or a pharmaceutically acceptable salt or ester thereof. 2. The compound according to Claim 1 wherein: X is -H, -Cl or -F; Y is -S(0)n-; R is -Ph, -tolyl, 3-Cl-phenyl, 2-pyridyl or 2-thiazolyl; R6 is -H; and Z is -C-NR 2 R 3 t -COOR 1b ι -COR 13 , W -CR2R2.s(0) n -Rl or -Cι_3alkyl substituted with heterocycle. 3. The compound according to Claim 2 wherein: X is -H or -Cl; Y is -S(0)n-; R is -Ph, -tolyl, 3-Cl-phenyl or 2-thiazolyl; R6 is -H; and Z is 1 ) -C-NR 2 R 3 , W wherein R2 is -H and W is -O, -S or -NCN, or 2) -CR2R2_sθ-aryl, wherein the aryl group is unsubstituted or substituted with one or more of Ci _5alkyl. 4. The compound according to Claim 3 wherein: 5. The compound according to Claim 1 wherein X is selected from the group consisting of: 1) -NR2R2, 2) -NHSθ2-Cι .3alkyl and 3) -NHCO-Cι _3alkyl. 6. The compound according to Claim 1 wherein Z is 2) Ci-3alkyl substituted with heterocycle wherein heterocycle is substituted with one or more of: a) halogen, b) oxo, c) -N0 2 , d) -NR2R2, e) -NHCO-Ci-3alkyl or f) -NHSθ2-Cι_3alkyl. 7. The compound according to Claim 1 wherein Y is -S(0)n- and R is -NR 2 R3. 8. A compound selected from the group consisting of: N-ethyl-5-chloro-3-ρhenylthioindole-2-carboxamide, N-2-hydroxyethyl-5-chloro-3-phenylthioindole-2-carboxamide, N-2-methoxyethyl-5-chloro-3-phenylthioindole-2-carboxamide, N-3-methoxybenzyl-5-chloro-3-phenylthioindole-2-carboxamide, N-4-pyridylmethyl-5-chloro-3-phenylthioindole-2-carboxamide, N-3-pyridylmethyl-5-chloro-3-phenylthioindole-2-carboxamide, N-2-furanylmethyl-5-chloro-3-phenylthioindole-2-carboxamide, N-3-pyridyl-5-chloro-3-phenylthioindole-2τcarboxamide, N- [ 1 -(2(R)-hydroxypropyl)] -5 -chloro-3-phenylthioindole-2- carboxamide, N-(2-pyridyl)methyl-5-chloro-3-phenylthioindole-2-carboxamide, N-(3-methoxy-4-pyridyl)methyl-5-chloro-3-phenylthioindole-2- carboxamide, N-(3-hydroxymethyl)benzyl-5-chloro-3-phenylthioindole-2- carboxamide, 5-chloro-3-phenylthioindole-2-carboxamide, N-(3-hydroxybenzyl)-5-chloro-3-phenylthioindole-2-carboxamide, N-2-furanylmethyl-5-chloro-3-phenylthioindole-2-thiocarboxamide, 5-chloro-3-phenylthioindole-2-thiocarboxamide, 5-chloro-3-phenylsulfinylindole-2-carboxamide, and 5-chloro-3-phenylsulfonylindole-2-carboxamide, or a pharmaceutically acceptable salt or ester thereof. 9. A compound selected from the group consisting of: N-ethyl-5-chloro-3-phenylthioindole-2-carboxamide, N-2-hydroxyethyl-5-chloro-3-phenylthioindole-2-carboxamide, N-2-methoxyethyl-5-chloro-3-phenylthioindole-2-carboxamide, N-3-methoxybenzyl-5-chloro-3-phenylthioindole-2-carboxamide, N-4-pyridylmethyl-5-chloro-3-phenylthioindole-2-carboxamide, N-3-pyridylmethyl-5-chloro-3-phenylthioindole-2-carboxamide, N-2-furanylmethyl-5-chloro-3-phenylthioindole-2-carboxamide, and N-3-pyridyl-5-chloro-3-phenylthioindole-2-carboxamide, or a pharmaceutically acceptable salt or ester thereof. 10. A compound selected from the group consisting of: N-[ 1 -(2(R)-hydroxypropyl)]-5-chloro-3-phenyl-thioindole-2- carboxamide, N-(2-pyridyl)methyl-5-chloro-3-phenylthioindole-2-carboxamide, N-(3-methoxy-4-pyridyl)methyl-5-chloro-3-phenyl-thioindole-2- carboxamide, N-(3-hydroxymethyl)benzyl-5-chloro-3-phenyl-thioindole-2- carboxamide, 5-chloro-3-phenylthioindole-2-carboxamide, N-(3-hydroxybenzyl)-5-chloro-3-phenylthioindole-2-carboxamide, N-2-furanylmethyl-5-chloro-3-phenylthioindole-2-thiocarboxamide, and 5-chloro-3-phenylthioindole-2-thiocarboxamide, or a pharmaceutically acceptable salt or ester thereof. 11. A compound selected from the group consisting of: 5-chloro-3-phenylsulfinylindole-2-carboxamide, and 5-chloro-3-phenylsulfonylindole-2-carboxamide, or a pharmaceutically acceptable salt thereof. 12. A compound selected from the group consisting of: N-[(l-methyliιnidazol-2-yl)methyl]-3-phenylsulfonyl-5-chloroindole-2- carboxamide, N-[(l-methylimidazol-2-yl)methyl]-3-phenylsulfinyl-5-chloroindole-2- carboxamide, N-[(l-methylimidazol-4-yl)methyl]-3-ρhenylsulfonyl-5-chloroindole-2- carboxamide, N-[(l-methylimidazol-5-yl)methyl]-3-phenylsulfonyl-5-chloroindole-2- carboxamide, N- [( 1 -methylimidazol-2-y l)methyl] -3 -(3 -chlorophenylsulf onyl)-5 - chloroindole-2-carboxamide, N-[2-(imidazol-4-yl)ethyl]-3-phenylsulfonyl-5-chloroindole-2- carboxamide, N-[2-(l-methylimidazol-4-yl)ethyl]-3-phenyl-sulfonyl-5-chloroindole-2- carboxamide, N-cyclopropyl-5-chloro-3-phenylsulfonylindole-2-carboxamide, N-cyclobutyl-5-chloro-3-phenylsulfonylindole-2-carboxamide, N-(3-ρyridylmethyl)-3-phenylsulfonyl-5-chloroindole-2-carboxamide, N-(4-pyridylmethyl)-5-chloro-3-phenylsulfinyl-indole-2-carboxamide, N-(3-anτ ob nzyl)-3-phenylsulfonyl-5-cWoroindole-2-carboxamide, N-(3-methoxybenzyl)-5-chloro-3-(2-thiazolyl)-sulfonylindole-2- carboxamide, N-[(S)-l-phenyl-2-hydroxyethyl]-5-chloro-3-phenylsulfonylindole-2- carboxamide, N-[(R)-l-phenylemyl]-5-chloro-3-phenylsulfonyl-indole-2-carboxamide, N-(3-methylsulfonylaminobenzyl)-3-phenylsulfonyl-5-chloroindole-2- carboxamide, N-cyano-5-chloro-3-phenylsulfonylindole-2-carboximidamide, 3-phenylsulfonyl-5-methylsulfonylaminoindole-2-carboxamide, 4-[(5-cUoro-3-phenylsulfonylmdole-2-carboxamido)-methyl]pyridin- 2(lH)-one, N-(2-amino-4-pyridylmethyl)-5-chloro-3-phenyl-sulfonylindole-2- carboxamide, and N-cyclopropyl-5-chloro-3-phenylsulfinylindole-2-carboxamide, or a pharmaceutically acceptable salt or ester thereof. 13. The compound N-[(l-methylimidazol-2-yl)- methyl]-3-phenylsulfonyl-5-chloroindole-2-carboxamide, or a pharmaceutically acceptable salt thereof. 14. A method of inhibiting HTV reverse transcriptase, comprising administering to a mammal an effective amount of a compound of Claim 1. 15. A method of preventing infection of HTV, or of treating infection by HIV or of treating AIDS or ARC, comprising administering to a mammal an effective amount of a compound of Claim 1. 16. A pharmaceutical composition useful for inhibiting HTV reverse transcriptase, comprising an effective amount of a compound of Claim 1, and a pharmaceutically acceptable carrier. 17. A pharmaceutical composition useful for preventing or treating infection of HTV or for treating AIDS or ARC, comprising an effective amount of a compound of Claim 1, and a pharmaceutically acceptable carrier.

Inventors: BALANI SURESH K, CICCARONE TERRENCE M, GOLDMAN MARK E, GREENLEE WILLIAM J, HOFFMAN JACOB M JR, HUFF JOEL R, LUMMA WILLIAM C JR, ROONEY CLARENCE S, SAARI WALFRED S, SANDERSON PHILIP E, THEOHARIDES ANTHONY D DI, WAI JOHN S, WILLIAMS THERESA M, BALANI, SURESH, K., CICCARONE, TERRENCE, M., GOLDMAN, MARK, E., GREENLEE, WILLIAM, J., HOFFMAN, JACOB, M., JR., HUFF, JOEL, R., LUMMA, WILLIAM, C., JR., ROONEY, CLARENCE, S., SAARI, WALFRED, S., SANDERSON, PHILIP, E., THEOHARIDES, ANTHONY, D. +DI, WAI, JOHN, S., WILLIAMS, THERESA, M.
Applicants: MERCK & CO INC, THEOHARIDES SHARON A & EF, MERCK & CO., INC., THEOHARIDES, SHARON, A. +EF
Application year: 1994
Main classification: C07D209
IPC codes: A61K31, A61P31, A61P37, C07D209, C07D401, C07D403, C07D405, C07D413, C07D417, C07D521