MORPHOLINE AND THIOMORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS

Abstract: Substituted heterocycles of general structural formula (I) or a pharmaceutically acceptable salt thereof, wherein: R<1> is selected from the group consisting of: hydrogen; C1-6 alkyl, unsubstituted or substituted; C2-6 alkenyl, unsubstituted or substituted; C2-6 alkynyl; phenyl, unsubstitued or substituted; X is selected from the group consisting of: -O-, -S-, -SO-, -SO2-; Y is selected from the group consisting of: a single bond, -O-, -S-, -CO-, -CH2, -CHR5- and -CR<15>R<16>; Z = C1-6 alkyl, are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.

Description: TITLE OF THE INVENTION MORPHOLINE AND THIOMORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS BACKGROUND OF THE INVENTION Analgesia has historically been achieved in the central nervous system by opiates and analogs which are addictive, and peripherally by cyclooxygenase inhibitors that have gastric side effects. Substance P antagonists may induce analgesia both centrally and peripherally. In addition, substance P antagonists are inhibitory of neurogenic inflammation. The neuropeptide receptors for substance P (neurokinin-1; NK-1) are widely distributed throughout the mammalian nervous system (especially brain and spinal ganglia), the circulatory system and peripheral tissues (especially the duodenum and jejunum) and are involved in regulating a number of diverse biological processes. This includes sensory perception of olfaction, vision, audition and pain, movement control, gastric motility, vasodilation, salivation, and micturition (B. Pernow, Pharmacol. Rev.. 1983, , 85-141). The NK-1 and NK-2 receptor subtypes are implicated in synaptic transmission (Laneuville et al., Life Sci.. 42: 1295-1305 (1988)). The receptor for substance P is a member of the superfamily of G protein-coupled receptors. This superfamily is an extremely diverse group of receptors in terms of activating ligands and biological functions. In addition to the tachykinin receptors, this receptor superfamily includes the opsins, the adrenergic receptors, the muscarinic receptors, the dopamine receptors, the serotonin receptors, a thyroid-stimulating hormone receptor, a luteinizing hormone- choriogonadotropic hormone receptor, the product of the oncogene ras, the yeast mating factor receptors, a Dictvostelium cAMP receptor, and receptors for other hormones and neurotransmitters (see A.D. Hershey, et al., J. Biol. Chem.. 1991, 226, 4366-4373). Substance P (also called "SP" herein) is a naturally occurring undecapeptide belonging to the tachykinin family of peptides, the latter being so-named because of their prompt contractile action on extravascular smooth muscle tissue. The tachykinins are distinguished by a conserved carboxyl-terminal sequence Phe-X-Gly-Leu-Met-NH2. In addition to SP the known mammalian tachykinins include neurokinin A and neurokinin B. The current nonmenclature designates the receptors for SP, neurokinin A, and neurokinin B as NK-1, NK-2, and NK-3, respectively. More specifically, substance P is a pharmacologically-active neuropeptide that is produced in mammals and possesses a characteristic amino acid sequence (Chang et ah, Nature New Biol. 232. 86 (1971); D.F. Veber et al*, U.S. Patent No. 4.680.283). Substance P is a pharmacologically-active neuropeptide that is produced in mammals and acts as a vasodilator, a depressant, stimulates salivation and produces increased capillary permeability. It is also capable of producing both analgesia and hyperalgesia in animals, depending on dose and pain responsiveness of the animal (see R.C. A. Frederickson et al., Science. 199. 1359 (1978); P. Oehme et al., Science. 208. 305 (1980)) and plays a role in sensory transmission and pain perception (T.M. Jessell, Advan. Biochem. Psychopharmacol. 28. 189 (1981)). For example, substance P is believed to be involved in the neurotransmission of pain sensations [Otsuka et al, "Role of Substance P as a Sensory Transmitter in Spinal Cord and Sympathetic Ganglia" in 1982 Substance P in the Nervous System, Ciba Foundation Symposium 91, 13-34 (published by Pitman) and Otsuka and Yanagisawa, "Does Substance P Act as a Pain Transmitter?" TIPS. 8 506-510 (Dec. 1987)], specifically in the transmission of pain in migraine (see B.E.B. Sandberg et al., Journal of Medicinal Chemistry. 25, 1009 (1982); M. A. Moskowitz, Trends Pharmacol. Sci.. 13, 307-311 (1992)), and in arthritis (Levine, et ah Science. 226 547-549 (1984); M. Lotz, et aL, Science. 235, 893-895 (1987)). Tachykinins have also been implicated in gastrointestinal (GI) disorders and diseases of the GI tract, such as inflammatory bowel disease [see Mantyh et al*, Neuroscience. 25 (3), 817-37 (1988) and D. Regoli in "Trends in Cluster Headache" Ed. F. Sicuteri et al., Elsevier Scientific Publishers, Amsterdam, pp. 85-95 (1987)], and emesis ITrends Pharmacol. Sci.. 9. 334-341 (1988), F.D. Tatersall, et al., Eur. J. Pharmacol.. 250. R5-R6 (1993)]. It is also hypothesized that there is a neurogenic mechanism for arthritis in which substance P may play a role [Kidd et al., "A Neurogenic Mechanism for Symmetric Arthritis" in The Lancet. 11 November 1989 and Gronblad et aL, "Neuropeptides in Synovium of Patients with Rheumatoid Arthritis and Osteoarthritis" in J. Rheumatol. 15(12) 1807-10 (1988)]. Therefore, substance P is believed to be involved in the inflammatory response in diseases such as rheumatoid arthritis and osteoarthritis [O'Byrne et al*, Arthritis and Rheumatism. 33 1023-8 (1990)]. Evidence for the usefulness of tachykinin receptor antagonists in pain, headache, especially migraine, Alzheimer's disease, multiple sclerosis, attenuation of morphine withdrawal, cardiovascular changes, oedema, such as oedema caused by thermal injury, chronic inflammatory diseases such as rheumatoid arthritis, asthma/bronchial hyperreactivity and other respiratory diseases including allergic rhinitis, inflammatory diseases of the gut including ulcerative colitis and Chrohn's disease, ocular injury and ocular inflammatory diseases, proliferative vitreoretinopathy, irritable bowel syndrome and disorders of bladder function including cystitis and bladder detruser hyperreflexia is reviewed in "Tachykinin Receptors and Tachykinin Receptor Antagonists," CA. Maggi, R. Patacchini, P. Rovero and A. Giachetti, Auton. Pharmacol. H, 23-93 (1993); see also R. M. Snider, et aL, Chem. Ind., ϋ, 792-794 (1991). Neurokinin- 1 receptor antagonists alone or in combination with bradykinin receptor antagonists may also be useful in the prevention and treatment of inflammatory conditions in the lower urinary tract, especially cystitis [Giuliani, et al., J. Urology. 150. 1014-1017 (1993)]. Other disease areas where tachykinin antagonists are believed to be useful are allergic conditions [Hamelet et aL, Can. J. Pharmacol. PhvsioL. 66, 1361-7 (1988)], immunoregulation [Lύtz, et aL, Science. 241 1218-21 (1988), Kimball, et aL, J. Immunol.. 141 (10) 3564-9 (1988); A. Perianin, et al., Biochem. Biophvs. Res Commun. 161. 520 (1989)], post-operative pain and nausea [C. Bountra, et al., Eur. J. Pharmacol.. 249. R3-R4 (1993), F. D. Tattersall, et aL, Neuropharmacologv. 33, 259-260 (1994)], vasodilation, bronchospasm, reflex or neuronal control of the viscera [Mantyh et al., PNAS. 85, 3235-9 (1988)] and, possibly by arresting or slowing β-amyloid- mediated neurodegenerative changes [Yankner et aL, Science. 250. 279- 82 (1990)] in senile dementia of the Alzheimer type, Alzheimer's disease and Downs Syndrome. Substance P may also play a role in demyelinating diseases such as multiple sclerosis and amyotrophic lateral sclerosis [J. Luber-Narod, et. aL, poster C.I.N.P. XVIIIth Congress, 28th June-2nd July, 1992], and in disorders of bladder function such as bladder detrusor hyper-reflexia [Lancet. 16th May 1992, 1239]. Antagonists selective for the neurokinin-1 (NK-1) and/or the neurokinin-2 (NK-2) receptor may be useful in the treatment of asthmatic disease (Frossard et al., Life Sci.. 49, 1941-1953 (1991); Advenier, et aL, Biochem. Biophvs. Res. Comm.. 184(3). 1418-1424 (1992); P. Barnes, et al., Trends Pharmacol. Sci.. U, 185-189 (1993)). Tachykinin antagonists may also be useful in the treatment of small cell carcinomas, in particular small cell lung cancer (SCLC) [Langdon et al., Cancer Research. 52, 4554-7 ( 1992)] . It has furthermore been suggested that tachykinin receptor antagonists have utility in the following disorders: depression, dysthymic disorders, chronic obstructive airways disease, hypersensitivity disorders such as poison ivy, vasospastic diseases such as angina and Reynauld's disease, fibrosing and collagen diseases such as scleroderma and eosinophillic fascioliasis, reflex sympathetic dystrophy such as shoulder/hand syndrome, addiction disorders such as alcoholism, stress related somatic disorders, neuropathy, neuralgia, disorder related to immune enhancement or suppression such as systemic lupus erythmatosus (EPO Publication No. 0,436,334), ophthalmic diseases such as conjunctivitis, vernal conjunctivitis, and the like, and cutaneous diseases such as contact dermatitis, atopic dermatitis, urticaria, and other eczematoid dermatitis (EPO Publication No. 0,394,989). Substance P antagonists may be useful in mediating neurogenic mucus secretion in mammalian airways and hence provide treatment and symptomatic relief in diseases characterized by mucus secretion, in particular, cystic f brosis [S. Ramnarine, et al., abstract presented at 1993 ALA/ATS Int'l Conference, 16-19 May, 1993, published in Am. Rev, of Respiratory Pis.. May 1993]. In the recent past, some attempts have been made to provide peptide-like substances that are antagonists for the receptors of substance P and other tachykinin peptides in order to more effectively treat the various disorders and diseases mentioned above. For example Lowe, Drugs of the Future. 17 (12) 1115-1121 (1992) and EPO Publication Nos. 0,347,802, 0,401,177 and 0,412,452 disclose various peptides as neurokinin A antagonists. Also, PCT Patent Publication WO 93/14113 discloses certain peptides as tachykinin antagonists. In addition, EPO Publication No. 0,336,230 discloses heptapeptides which are substance P antagonists useful in the treatment of asthma. Merck U.S. Patent No. 4,680,283 also discloses peptidal analogs of substance P. Certain inhibitors of tachykinins have been described in U.S. Patent No. 4,501,733, by replacing residues in substance P sequence by Tip residues. A further class of tachykinin receptor antagonists, comprising a monomeric or dirneric hexa- or heptapeptide unit in linear or cyclic form, is described in GB-A-2216529. The peptide-like nature of such substances make them too labile from a metabolic point of view to serve as practical therapeutic agents in the treatment of disease. The non-peptidic antagonists of the present invention, on the other hand, do not possess this drawback, as they are expected to be more stable from a metabolic point of view than the previously-discussed agents. It is known that in the central nervous system baclofen [β-(aminoethyl)-4-chlorobenzenepropanoic acid] effectively blocks the excitatory activity of substance P, but because in many areas the excitatory responses to other compounds such as acetylcholine and glutamate are inhibited as well, baclofen is not considered a specific substance P antagonist. Pfizer WIPO patent applications (PCT Publication Nos. WO 90/05525. WO 90/05729. WO 91/18899. WO 92/12151 and WO 92/12152) and publications (Science. 251. 435-437 (1991); Science. 251. 437-439 (1991); J. Med. Chem.. 35, 2591-2600 (1992)) disclose 2-arylmethyl-3-substituted amino-quinuclidine derivatives which are disclosed as being useful as substance P antagonists for treating gastrointestinal disorders, central nervous system disorders, inflammatory diseases and pain or migraine. A Glaxo European patent application (EPO Publication No. 0.360.390) discloses various spirolactam-substituted amino acids and peptides which are antagonists or agonists of substance P. A Pfizer WIPO patent application (PCT Publication No. WO 92/06079) discloses fused-ring analogs of nitrogen-containing nonaromatic heterocycles as useful for the treatment of diseases mediated by an excess of substance P. A Pfizer WIPO patent application (PCT Publication No. WO 92/15585 discloses l-azabicyclo[3.2.2]nonan-3-amine derivatives as substance P antagonists. A Pfizer WIPO patent application (PCT Publication No. WO 93/10073) discloses ethylenediamine derivatives as substance P antagonists. PCT Publication No. WO 93/01169 discloses certain aromatic compounds as tachykinin receptor antagonists. A Sanofi publication (Life Sci.. 50. PL ID 1 -PL 106 (1992)) discloses a 4-phenyl piperidine derivative as an antagonist of the neurokinin A (NK2) receptor. Howson et al. (Biorg. & Med. Chem. Lett.. 2 (6), 559-564 (1992)) disclose certain 3-amino and 3-oxy quinuclidine compounds and their binding to substance P receptors. EPO Publication 0.499.313 discloses certain 3-oxy and 3-thio azabicyclic compounds as tachykinin antagonists. U.S. Patent No. 3.506.673 discloses certain 3-hydroxy quinuclidine compounds as central nervous system stimulants. A Pfizer EPO Patent application (EPO Publication 0.436.334) discloses certain 3- aminopiperidine compounds as substance P antagonists. U.S. Patent No. 5.064.838 discloses certain 1,4-disubstituted piperidinyl compounds as analgesics. PCT Publication No. WO 92/12128 discloses certain piperidine and pyrrolidine compounds as analgesics. Peyronel, et al. (Biorg & Med. Chem. Lett.. 2 (1), 37-40 (1992)) disclose a fused ring pyrrolidine compound as a substance P antagonist. EPO Publication No. 0.360.390 discloses certain spirolactam derivatives as substance P antagonists. U.S. Patent No. 4.804.661 discloses certain piperazine compounds as analgesics. U.S. Patent No. 4.943.578 discloses certain piperazine compounds useful in the treatment of pain. PCT Publication No. WO 92/01679 discloses certain 1,4-disubstituted piperazines useful in the treatment of mental disorders in which a dopaminergic deficit is implicated. PCT Publication No. WO 94/00440 discloses certain morpholine compounds as substance P antagonists. SUMMARY OF THE INVENTION This invention is concerned with novel compounds represented by structural formula I: wherein Rl, R2, R3, R4 5 R5 ? and X are hereinafter defined. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are tachykinin receptor antagonists and are useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis. Also, some of these compounds are calcium channel blockers and are useful in the treatment of cardiovascular disorders such as angina, hypertension or ischemia. DETAILED DESCRIPTION OF THE INVENTION The novel compounds of this invention are represented by structural formula I: or a pharmaceutically acceptable salt thereof, wherein: Rl is selected from the group consisting of: (1) hydrogen; (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, wherein halo is fluoro, chloro, bromo or iodo, (h) -NR9R 10, wherein R9 and R 10 are independently selected from: (i) hydrogen, (ii) Cl-6 alkyl, (iii) hydroxy-Cl-6 alkyl, and (iv) phenyl, (i) -NR9COR10, wherein R9 and RlO are as defined above, (j) -NR9C02R 10 , wherein R9 and RlO are as defined above, (k) -CONR9R10, wherein R9 and RlO are as defined above, (1) -COR9, wherein R9 is as defined above, (m) -C02R9, wherein R9 is as defined above; (n) heterocycle, wherein the heterocycle is selected from the group consisting of: (A) benzimidazolyl, (B) benzofuranyl, (C) benzothiophenyl, (D) benzoxazolyl, (E) furanyl, (F) imidazolyl, (G) indolyl, (H) isooxazolyl, (I) isothiazolyl, (J) oxadiazolyl, (K) oxazolyl, (L) pyrazinyl, (M) pyrazolyl, (N) pyridyl, (O) pyrimidyl, (P) pyrrolyl, (Q) quinolyl, (R) tetrazolyl, (S) thiadiazolyl, (T) thiazolyl, (U) thienyl, (V) triazolyl, (W) azetidinyl, (X) 1,4-dioxanyl, (Y) hexahydroazepinyl, (Z) piperazinyl, (AA) piperidinyl, (AB) pyrrolidinyl, (AC) tetrahydrofuranyl, and (AD) tetrahydrothienyl, and wherein the heterocycle is unsubstituted or substituted with one or more substituent(s) selected from: (i) Cl-6 alkyl, unsubstituted or substituted with halo, -CF3, -OCH3, or phenyl, (ii) Cl-6 alkoxy, (111) oxo, (iv) hydroxy, (v) thioxo, (vi) -SR9, wherein R9 is as defined above, (vii) halo, ( ,vn ..i..) cyano, (ix) phenyl, (x) trifluoromethyl, (xi) -(CH2)m-NR9RlO, wherein m is 0, 1 or 2, and R9 and RlO are as defined above, (xii) -NR9COR10, wherein R9 and RlO are as defined above, (xiii) -CONR9R10, wherein R9 and RlO are as defined above, (xiv) -CO2R9, wherein R9 is as defined above, and (xv) -(CH2)m-OR9, wherein m and R9 are as defined above; (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, . (f) -CN, (g) halo, (h) -CONR9R10 wherein R9 and RlO are as defined above, R3 are independently selected from the group consisting of: (1) hydrogen, (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR9R10, wherein R9 and RlO are as defined above, (i) -NR9COR10, wherein R9 and RlO are as defined above, (j) -NR9CO2R10, wherein R9 and RlO are as defined above, (k) -CONR9R10, wherein R9 and RlO are as defined above, (1) -COR9, wherein R9 is as defined above, and (m) -C02R9, wherein R9 is as defined above; (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR9R10 wherein R9 and RlO are as defined above, (i) -COR9 wherein R9 is as defined above, (j) -C02R9, wherein R9 is as defined above; (4) C2-6 alkynyl; (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) Cl-6 alkoxy, and the groups Rl and R2 may be joined together to form a heterocyclic ring selected from the group consisting of: (a) * pyrrolidinyl, (b) piperidinyl, (c) pyrrolyl, (d) pyridinyl, (e) imidazolyl, (f) oxazolyl, and (g) thiazolyl, and wherein the heterocyclic ring is unsubstituted or substituted with one or more substituent(s) selected from: (i) Ci-6alkyl, (ii) oxo, (iii) Cl-6alkoxy, (iv) -NR9R10, wherein R9 and RlO are as defined above, (v) halo, and (vi) trifluoromethyl; and the groups R2 and R3 may be joined together to form a carbocyclic ring selected from the group consisting of: (a) cyclopentyl, (b) cyclohexyl, (c) phenyl, and wherein the carbocyclic ring is unsubstituted or substituted with one or more substituents selected from: (i) Cl-6alkyl, (ii) Cl-6alkoxy, (iii) -NR9R10, wherein R9 and RlO are as defined above, (iv) halo, and v) trifluoromethyl; and the groups R2 and R3 may be joined together to form a heterocyclic ring selected from the group consisting of: (a) pyrrolidinyl, (b) * piperidinyl, (c) pyrrolyl, (d) pyridinyl, (e) imidazolyl, (f) furanyl, (g) oxazolyl, (h) thienyl, and (i) thiazolyl, and wherein the heterocyclic ring is unsubstituted or substituted with one or more substituent(s) selected from: (i) Cl-6alkyl, (ii) oxo, (iii) Cl-6alkoxy, (iv) -NR9R 10, wherein R9 and R 10 are as defined above, (v) halo, and (vi) trifluoromethyl; elected from the group consisting of: (1) (2) (3) -Y-C2-6 alkenyl, wherein the alkenyl is unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR9R10 wherein R9 and RlO are as defined above, (i) -COR9 wherein R9 is as defined above, (j) -Cθ2R9, wherein R9 is as defined above; (4) -0(CO)-phenyl, wherein the phenyl is unsubstituted or substituted with one or more of R6, R7 and R8; elected from the group consisting of: (1) phenyl, unsubstituted or substituted with one or more of RH, Rl2 and Rl3; (2) Cl-8 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, ( ) -CN, (g) halo, (h) -NR9R10, wherein R9 and RlO are as defined above, (i) -NR9COR10, wherein R9 and RlO are as defined above, (j ) -NR9C02R 10, wherein R9 and R 10 are as defined above, (k) -CONR9R10, wherein R9 and RlO are as defined above, (1) -COR9, wherein R9 is as defined above, and (m) -C02R9, wherein R9 is as defined above; (3) (4) heterocycle, wherein the heterocycle is as defined above; R6, R7 and R8 are independently selected from the group consisting of: (1) hydrogen; (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (h) -CF3, G) -(CH2)m-NR9RlO, wherein m, R9 and RlO are as defined above, G) -NR9COR10, wherein R9 and RlO are as defined above, (k) -NR9CO2R10, wherein R9 and RlO are as defined above, (1) -CONR9R10, wherein R9 and RlO are as defined above, (m) -CO2NR9R10, wherein R9 and RlO are as defined above, (n) -COR9, wherein R9 is as defined above; (o) -C02R9, wherein R9 is as defined above; (6) halo, (7) -CN, (8) -CF 3 , (9) -Nθ2, (10 -SR14, wherein Rl4 is hydrogen or Cl-5alkyl, (11 -SOR14, wherein Rl4 is as defined above, (12 -Sθ2Rl4, wherein Rl4 is as defined above, (13 NR9COR10, wherein R9 and RlO are as defined above, (14 CONR9COR10, wherein R9 and RlO are as defined above, (15 NR9R10, wherein R9 and RlO are as defined above, (16 NR9CO2R10, wherein R9 and RlO are as defined above, (17 hydroxy, (18 Cl-6alkoxy, (19 COR9, wherein R9 is as defined above, (20 Cθ2R9, wherein R9 is as defined above, (21 2-pyridyl, (22 3-pyridyl, (23 4-pyridyl, (24 5-tetrazolyl, (25 2-oxazolyl, and (26 2-thiazolyl; Rl l, Rl2 and Rl3 are independently selected from the definitions of R6, R7 and R8 ; X is selected from the group consisting of: (xi) -CONR9R 10, wherein R9 and RlO are as defined above, (xii) -COR9, wherein R9 is as defined above, and (xiii) -Cθ2R9, wherein R9 is as defined above; (b) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (i) hydroxy, (ii) Cl-6 alkoxy, (iii) Cl-6 alkyl, (iv) C2-5 alkenyl, (v) halo, (vi) -CN, (vii) -N02, (viii) -CF3, (ix) -(CH2)m-NR9RlO, wherein m, R9 and RlO are as defined above, (x) -NR9COR10, wherein R9 and RlO are as defined above, (xi) -NR9CO2R10, wherein R9 and RlO are as defined above, (xii) -CONR9R10, wherein R9 and RlO are as defined above, (xiii) -CO2NR9R10, wherein R9 and RlO are as defined above, (xiv) -COR9, wherein R9 is as defined above, and (xv) -C02R9, wherein R9 is as defined above; Z is selected from: (1) hydrogen, (2) Cl-6 alkyl, and (3) hydroxy, with the proviso that if Y is -0-, Z is other than hydroxy, or if Y is -CHR15-, then Z and Rl5 may be joined together to form a double bond. The compounds of the present invention have asymmetric centers and this invention includes all of the optical isomers and mixtures thereof. In addition compounds with carbon-carbon double bonds may occur in Z- and E- forms with all isomeric forms of the compounds being included in the present invention. When any variable (e.g., alkyl, aryl, R6, R7, R8, R9, RlO, Rl l, Rl2, Rl3, etc.) occurs more than one time in any variable or in Formula I, its definition on each ocurrence is independent of its definition at every other occurrence. As used herein, the term "alkyl" includes those alkyl groups of a designated number of carbon atoms of either a straight, branched, or cyclic configuration. Examples of "alkyl" include methyl, ethyl, propyl, isopropyl, butyl, iso- sec- and tert-butyl, pentyl, hexyl, heptyl, 3-ethylbutyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, norbornyl, and the like. "Alkoxy" represents an alkyl group of indicated number of carbon atoms attached through an oxygen bridge, such as methoxy, ethoxy, propoxy, butoxy and pentoxy. "Alkenyl" is intended to include hydrocarbon chains of a specified number of carbon atoms of either a straight- or branched- configuration and at least one unsaturation, which may occur at any point along the chain, such as ethenyl, propenyl, butenyl, pentenyl, dimethylpentyl, and the like, and includes E and Z forms, where applicable. "Halogen" or "halo", as used herein, means fluoro, chloro, bromo and iodo. The term "aryl" means phenyl or naphthyl either unsubstituted or substituted with one, two or three substituents selected from the group consisting of halo, Cl-4-alkyl, Cl-4-alkoxy, N02, CF3, Cl-4-alkylthio, OH, -N(R6)2, -CO2R6, Cl-4-perfluoroalkyl, C3-6- perfluorocycloalkyl, and tetrazol-5-yl. The term "heteroaryl" means an unsubstituted, monosubstituted or disubstituted five or six membered aromatic heterocycle comprising from 1 to 3 heteroatoms selected from the group consisting of O, N and S and wherein the substituents are members selected from the group consisting of -OH, -SH, -C 1-4- alkyl, -Cl-4-alkoxy, -CF3, halo, -Nθ2, -Cθ2R 9 ,-N(R9RlO) and a fused benzo group. As will be understood by those skilled in the art, pharmaceutically acceptable salts include, but are not limited to salts with inorganic acids such as hydrochloride, sulfate, phosphate, diphosphate, hydrobromide, and nitrate or salts with an organic acid such as malate, maleate, fumarate, tartrate, succinate, citrate, acetate, lactate, methanesulfonate, p-toluenesulfonate, 2-hydroxyethylsulfonate, pamoate, salicylate and stearate. Similarly, pharmaceutically acceptable cations include, but are not limited to sodium, potassium, calcium, aluminum, lithium and ammonium. A preferred embodiment of the present invention is directed to compounds of the formula: or a pharmaceutically acceptable salt thereof, wherein: Rl is selected from the group consisting of: (1) hydrogen; (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, wherein halo is fluoro, chloro, bromo or iodo, (h) -NR9R10, wherein R9 and RlO are independently selected from: (i) hydrogen, (ii) Cl-6 alkyl, (iii) hydroxy-Cl-6 alkyl, and (iv) phenyl, (i) -NR9COR10, wherein R9 and RlO are as defined above, (j ) -NR9C02R 10, wherein R9 and R 10 are as defined 10 above, (k) -CONR9R10, wherein R9 and RlO are as defined above, (1) -COR9, wherein R9 is as defined above, (m) -C02R9, wherein R9 is as defined above; 15 (n) heterocycle, wherein the heterocycle is selected from the group consisting of: (A) benzimidazolyl, (B) benzofuranyl, (C) benzothiophenyl, 20 (D) benzoxazolyl, (E) furanyl, (F) imidazolyl, (G) indolyl, (H) isooxazolyl, 25 (I) isothiazolyl, (J) oxadiazolyl, (K) oxazolyl, (L) pyrazinyl, (M) pyrazolyl, 30 (N) pyridyl, (O) pyrimidyl, (P) pyrrolyl, (Q) quinolyl, (R) tetrazolyl, (S) thiadiazolyl, (T) thiazolyl, (U) thienyl, (V) triazolyl, (W) azetidinyl, (X) 1,4-dioxanyl, (Y) hexahydroazepinyl, (Z) piperazinyl, (AA) piperidinyl, 10 (AB) pyrrolidinyl, (AC) tetrahydrofuranyl, and (AD) tetrahydrothienyl, and wherein the heterocycle is unsubstituted or substituted with one or more substituent(s) 15 selected from: (i) Cl-6 alkyl, unsubstituted or substituted with halo, -CF3, -OCH3, or phenyl, (ii) Cl-6 alkoxy, (iii) oxo, 20 (iv) hydroxy, (v) thioxo, (vi) -SR9, wherein R9 is as defined above, (vii) halo, (viii) cyano, 25 (ix) phenyl, (x) trifluoromethyl, (xi) -(CH2)m-NR9RlO, wherein m is 0, 1 or 2, and R9 and RlO are as defined above, (xii) -NR9COR10, wherein R9 and RlO are 30 as defined above, (xiii) -CONR9R10, wherein R9 and RlO are as defined above, (xiv) -C02R9, wherein R9 is as defined above, and (xv) -(CH2)m-OR9, wherein m and R9 are as defined above; (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR9R10 wherein R9 and RlO are as defined above, (i) -COR9 wherein R9 is as defined above, (j) -C02R9, wherein R9 is as defined above, (k) heterocycle, wherein the heterocycle is as defined above; (4) C2-6 alkynyl; (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) Cl-6 alkoxy, (c) Cl-6 alkyl, (d) C2-5 alkenyl, (e) halo, (f) -CN, (g) -N02, (h) -CF3, (i) -(CH2)m-NR9RlO, wherein m, R9 and RlO are as defined above, G) -NR9COR10, wherein R9 and RlO are as defined above, (k) -NR9C02R 10, wherein R9 and R 10 are as defined above, (1) -CONR9R 10, wherein R9 and R 10 are as defined above, (m) -C02NR9R 10, wherein R9 and R 10 are as defined above, (n) -COR9, wherein R9 is as defined above; (0) -C02R9, wherein R9 is as defined above; R3 are independently selected from the group consisting of: (1) hydrogen, (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR9R10, wherein R9 and RlO are as defined above, (i) -NR9COR 10, wherein R9 and Rl 0 are as defined above, (j) -NR9CO2R10, wherein R9 and RlO are as defined above, (k) -CONR9R10, wherein R9 and RlO are as defined above, (1) -COR9, wherein R9 is as defined above, and (m) -C02R9, wherein R9 is as defined above; (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, above, (m) -C02NR9R 10, wherein R9 and R 10 are as defined above, (n) -COR9, wherein R9 is as defined above; (o) -C02R9, wherein R9 is as defined above; and the groups R2 and R3 may be joined together to form a carbocyclic ring selected from the group consisting of: (a) cyclopentyl, (b) cyclohexyl, (c) phenyl, and wherein the carbocyclic ring is unsubstituted or substituted with one or more substituents selected from: (i) Ci-6alkyl, (ii) Cl-6alkoxy, (iii) -NR9R10, wherein R9 and RlO are as defined above, (iv) halo, and (v) trifluoromethyl; and the groups R2 and R3 may be joined together to form a heterocyclic ring selected from the group consisting of: (a) pyrrolidinyl, (b) piperidinyl, (c) pyrrolyl, (d) pyridinyl, (e) imidazolyl, (f) furanyl, (g) oxazolyl, (h) thienyl, and (i) thiazolyl, and wherein the heterocyclic ring is unsubstituted or substituted with one or more substituent(s) selected from: (i) Cl-6alkyl, ,... (ll) oxo, (iii) Cl-6alkoxy, (iv) -NR9R10, wherein R9 and RlO are as defined above, (v) halo, and (vi) trifluoromethyl; R6, R7 and R8 are independently selected from the group consisting of: (1) hydrogen; (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR9R10, wherein R9 and RlO are as defined above, (j) -NR9COR10, wherein R9 and RlO are as defined above, (k) -NR9C02R ! 0, wherein R9 and R 10 are as defined above, (1) -CONR9R10, wherein R9 and RlO are as defined above, (m) -CO2NR9R10, wherein R9 and RlO are as defined above, (n) -COR9, wherein R9 is as defined above; (o) -C02R9, wherein R9 is as defined above; (6) halo, (7) -CN, (8) -CF 3 , (9) -Nθ2, (10 -SR14, wherein Rl4 is hydrogen or Cl-5alkyl, (11 -SOR14, wherein Rl4 is as defined above, (12 -SO2RI4, wherein Rl4 is as defined above, (13 NR9COR10, wherein R9 and RlO are as defined above, (14 CONR9COR10, wherein R9 and RlO are as defined above, (15 NR9R10 ? wherein R9 and RlO are as defined above, (16 NR9CO2R10, wherein R9 and RlO are as defined above, (17 hydroxy, (18 Cl-6alkoxy, (19 COR9, wherein R9 is as defined above, (20 C02R9, wherein R9 is as defined above, (21 2-pyridyl, (22 3-pyridyl, (23 4-pyridyl, (24; 5-tetrazolyl, (25 2-oxazolyl, and (26 2-thiazolyl; Rl 1, Rl2 and Rl3 are independently selected from the definitions of R6, R7 and R8; selected from the group consisting of: (a) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (i) hydroxy, (ii) oxo, (iii) Cl-6 alkoxy, (iv) phenyl-Cl-3 alkoxy, (v) phenyl, (vi) -CN, (vii) halo, (viii) -NR9R10, wherein R9 and RlO are as defined above, (ix) -NR9COR 10, wherein R9 and R 10 are as defined above, (x) -NR9CO2R10, wherein R9 and RlO are as defined above, (xi) -CONR9R 10, wherein R9 and RlO are as defined above, (xii) -COR9, wherein R9 is as defined above, and (xiii) -C02R9, wherein R9 is as defined above; (b) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (i) hydroxy, (ii) Cl-6 alkoxy, (iii) Cl-6 alkyl, (iv) C2-5 alkenyl, (v) halo, (vi) -CN, (vii) -N02, (viii) -CF3, (ix) -(CH2)m-NR9RlO, wherein m, R9 and RlO are as defined above, (x) -NR9COR 10, wherein R9 and R 10 are as defined above, (xi) -NR9C02R 10 , wherein R9 and RlO are as defined above, (xii) -CONR9R10, wherein R9 and RlO are as defined above, (xiii) -CO2NR9R10, wherein R9 and RlO are as defined above, (xiv) -COR9, wherein R9 is as defined above, and (xv) -C02R9, wherein R9 is as defined above; Z is Cl-6 alkyl. In the preferred embodiment of the present compounds it is more preferred that: Rl is Cl-6 alkyl, substituted with one or more of the substituents selected from: heterocycle, wherein the heterocycle is selected from the group consisting of: (A) benzimidazolyl, (B) imidazolyl, (C) isooxazolyl, (D) isothiazolyl, (E) oxadiazolyl, (F) pyrazinyl, (G) pyrazolyl, (H) pyridyl, (I) pyrrolyl, (J) tetrazolyl, 10 (K) thiadiazolyl, (L) triazolyl, and (M) piperidinyl, and wherein the heterocycle is unsubstituted or substituted with one or more substituent(s) selected 15 from: (i) Cl-6 alkyl, unsubstituted or substituted with halo, -CF3, -OCH3, or phenyl, (ii) Cl-6 alkoxy, 20 (iii) oxo, (iv) thioxo, (v) cyano, (vi) -SCH3, (vii) phenyl, 25 (viii) hydroxy, (ix) trifluoromethyl, (x) -(CH2)m-NR9RlO, wherein m is 0, 1 or 2, and wherein R9 and RlO are independently selected 30 from: (I) hydrogen, (II) Cl-6 alkyl, (III) hydroxy-Cl-6 alkyl, and (IV) phenyl, (xi) -NR9COR 10, wherein R9 and Rl 0 are as defined above, and (xii) -CONR9R10, wherein R9 and RlO are as defined above. In the preferred embodiment of present compounds it is also more preferred that: R2 and R3 are independently selected from the group consisting of: (1) hydrogen, (2) Cl-6 alkyl, (3) C2-6 alkenyl, and (4) phenyl; R6, R7 and R8 are independently selected from the group consisting of: (1) hydrogen, (2) Cl-6 alkyl, (3) fluoro, (4) chloro, (5) bromo, (6) iodo, and (7) -CF 3 ; Rl 1, Rl2 and Rl3 are independently selected from the group consisting of: (1) hydrogen, (2) Cl-6 alkyl, (3) fluoro, (4) chloro, (5) bromo, (6) iodo, and (7) -CF ; X is -O-; Y is -0-; and Z is C 1-4 alkyl. In the compounds of the present invention a preferred embodiment includes those compounds wherein Z is Cl-4 alkyl. An especially preferred embodiment of the present compounds includes those compounds wherein Z is -CH3. These compounds bearing a substituent on the alpha-carbon atom exibit advantageous pharmacological properties, in particular, enhanced duration of action in models of extravasation, presumably due to biological stability and resistance to enzymatic degradation. An embodiment of the novel compounds of this invention is that wherein X is O, R4 is -YCHZ-phenyl, and R5 is phenyl of structural formula: or a pharmaceutically acceptable salt thereof, wherein Rl, R2, R3, R6, R7, R8, Rl 1, Rl2, Rl3, Y and Z are as defined above. . Within this embodiment, a preferred class of compounds includes those compounds of the structural formula: or a pharmaceutically acceptable salt thereof, wherein Rl, R2, R3, R6, R7, R8, Rl 1, R12, Rl3, Y and Z are as defined in Claim 1. An even more preferred class of compounds within this embodiment includes those compounds of the structural formula III: or a pharmaceutically acceptable salt thereof, wherein Rl, R2, R3, R6, R7, R8, Rl 1, Rl2, Rl3 and Z are as defined in Claim 1. An alternate class of compounds within this embodiment includes those compounds of the structural formula II: or a pharmaceutically acceptable salt thereof, wherein Rl, R2, R3, R6, R7, R8, Rl 1, Rl2, Rl3 and Z are as defined in Claim 1. Another embodiment of the novel compounds of this invention is that wherein X is S, R4 is -Y-CHZ-phenyl, and R5 is phenyl of structural formula: or a pharmaceutically acceptable salt thereof, wherein Rl, R2, R3, R6, R7, R8, Rl 1, Rl2, Rl3, Y and Z are as defined above. Another embodiment of the novel compounds of this invention is that wherein X is SO, R4 is -Y-CHZ-phenyl, and R5 is phenyl of " structural formula: or a pharmaceutically acceptable salt thereof, wherein Rl, R2, R3, R6, R7, R8, Rl l, Rl2, Rl3, Y and Z are as defined above. Another embodiment of the novel compounds of this invention is that wherein X is S02, R4 is -Y-CHZ-phenyl, and R5 is phenyl of structural formula: or a pharmaceutically acceptable salt thereof, wherein Rl, R2, R3, R6, R7, R8, Rl l, Rl2, Rl3, Y and Z are as defined above. In the compounds of the present invention a preferred embodiment is that in which Rl is selected from the following group of substituents: N-S N-O 7 25 N NMe 9 ' 30 A particularly prefered embodiment of the compounds of the present invention includes those compounds wherein R is (1,2,4- triazolo)methyl or (5-oxo-lH,4H-l,2,4-triaxolo)methyl. Another particularly prefered embodiment of the compounds of the present invention includes those compounds wherein Rl is (l,3-imidazolo)methyl or (2-oxo-l,3-imidazolo)methyl. Specific prefered compounds within the present invention include: 1 ) (+/-)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3-phenyl- morpholine; 2) (2R,S)-(3,5-bis(trifluoromethyl)benzyloxy)-(3R)-ρhenyl-(6R)- methy 1-morpholine ; 3) (2R,S)-(3,5-bis(trifluoromethyl)benzyloxy)-(3S)-ρhenyl-(6R)- methyl-morpholine; 4) (+/-)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3-phenyl-4- methylcarboxamido-mo holine; 5) (+/-)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3-phenyl-4-methoxy- carbonylmethyl-moφholine; 6) 2-(2-(3,5-bis(trifluoromethyl)phenyl)ethenyl)-3-phenyl-5-oxo- moφholine; 7) 3-phenyl-2-(2-(3,5-bis(trifluoromethyl)phenyl)-ethyl)- morpholine; 8) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-ρhenyl-6-(S)- methyl-moφholine; 9) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(S)- methy 1-moφholine ; 10) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(S)- methyl-moφholine; 11) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(S)- methy 1-moφholine ; 12) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(R)- methy 1-moφholine ; 13) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)- methy 1-moφholine ; 14) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(R)- methyl-moφholine; 15) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)- methyl-moφholine; 16) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl- moφholine; 17) 4-(3-(l,2,4-triazolo)methyl)-2-(S)-(3,5-bis(trifluoro- methyl)benzyloxy)-3-(S)-phenyl-moφholine; 18) 4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-2-(S)-(3 ,5-bis- (trifluoromethyl)benzyloxy)-3-(S)-phenyl-moφholine; 19) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(R)- methyl-moφholine; 20) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(R)- methyl-moφholine; 21) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(R)- methy 1-moφholine ; 22) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(R)- methy 1-moφholine ; 23) 2-(R)-(3,5-bis(trifluoromethyl)-benzyloxy)-3-(S)-phenyl-5-(S)- methy 1-moφholine ; 24) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(S)- methy 1-moφholine ; 25) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)- methyl-moφholine; 26) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)- phenyl-moφholine; 27) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)- phenyl-moφholine; 28) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)- phenyl-moφholine; 29) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)- phenyl-moφholine; 30) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-6-(R)-methyl-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 31) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-6-(R)-methyl-4-(3-(5- oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-3-(S)-phenyl-moφholine; 32) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl- moφholine; 33) 4-(3-(l,2,4-triazolo)methyl)-2-(S)-(3,5-bis(trifluoro- methyl)benzyloxy)-3-(R)-phenyl-moφholine; 34) 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-2-(S)-(3,5-bis- (trifluoromethyl)benzyloxy)-3-(R)-phenyl-moφholine; 35) 4-(2-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoro-methyl)- benzyloxy)-3-(R)-phenyl-moφholine; 36) 4-(4-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(R)-phenyl-moφholine; 37) 4-(aminocarbonylmethyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(R)-phenyl-moφholine; 38) 4-(2-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-moφholine; 39) 4-(4-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-moφholine; 40) 4-(2-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-6-(R)-methyl-moφholine; 41) 4-(4-(imidazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-6(R)-methyl-moφholine; 42) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-((6-hydroxy)-hexyl)- 3-(R)-phenyl-moφholine; 43) 2-(S)-(3,5-bis(trifluoromethyl)benzyl.oxy)-4-(5-(methylamino- carbonyl)pentyl)-3-(R)-phenyl-moφholine; 44) 4-(3-(l,2,4-triazolo)methyl)-2-(3,5-dimethylbenzyloxy)-3- phenylmoφholine ; 45) 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-2-(3,5-dimethyl)- benzyloxy)-3-phenyl-moφholine; 46) 4-(3-(l,2,4-triazolo)methyl)-2-(3,5-di(tert-butyl)- benzyloxy)-3-phenylmoφholine; 47) 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-2-(3,5-di(tert-butyl)- benzyloxy)-3-phenyl-moφholine; 48) 4-(3-( 1 ,2,4-triazolo)methyl)-2-(3-(tert-butyl)-5-methyl- benzyloxy)-3-phenyl-moφholine; 49) 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-2-(3-(tert-butyl)-5- methylbenzyloxy)-3-phenyl-moφholine; 50) 4-(3-(l,2,4-triazolo)methyl)-2-(3-(trifluoro-methyl)-5- methyl-benzyloxy)-3-phenyl-moφholine; 51 ) 4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-2-(3-(trifluoro- methyl)-5-methylbenzyloxy)-3-phenyl-moφholine; 52) 4-(3-(l,2,4-triazolo)methyl)-2-(3-(tert-butyl)-5-(trifluoro- methyl)benzyloxy)-3-phenyl-moφholine; 53) 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-2-(3-(tert-butyl)-5- (trifliιoromethyl)benzyloxy)-3-phenyl-moφholine; 54) 4-(2-(imidazolo)methyl)-2-(3 ,5-dimethyl-benzyloxy)-3-phenyl- moφholine; 55) 4-(4-(imidazolo)methyl)-2-(3,5-dimethyl-benzyloxy)-3-phenyl- moφholine; 56) 4-(2-(imidazolo)methyl)-2-(3,5-di(tert-butyl)-benzyloxy)-3- phenyl-moφholine; 57) 4-(4-(imidazolo)methyl)-2-(3,5-di(tert-butyl)-benzyloxy)-3- phenyl-moφholine; 58) 4-(2-(imidazolo)methyl)-2-(3-(tert-butyl)-5-methylbenzyloxy)-3- phenyl-moφholine; 59) 4-(4-(imidazolo)methyl)-2-(3-(tert-butyl)-5-methylbenzyloxy)-3- phenyl-moφholine; 60) 4-(2-(imidazolo)methyl)-2-(3-(trifluoro-methyl)-5-methyl- benzyloxy)-3-phenyl-moφholine; 61 ) 4-(4-(imidazolo)methyl)-2-(3-(trifluoro-methyl)-5-methyl- benzyloxy)-3-phenyl-moφholine; 62) 4-(2-(imidazolo)methyl)-2-(3-(tert-butyl)-5-(trifluoromethyl)- benzyloxy)-3-phenyl-moφholine; 63) 2-(S)-(3,5-dichlorobenzyloxy)-3-(S)-phenyl-moφholine; 64) 2-(S)-(3,5-dichlorobenzyloxy)-4-(3-(5-oxo-lH,4H-l,2,4- triazolo)methyl)-3-(S)-phenylmoφholine; 65) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(methoxycarbonyl- methyl)-3-(S)-phenyl-moφholine; 66) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(carboxymethyl)-3- (S)-phenyl-moφholine; 67) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-((2-aminoethyl)- aminocarbonylmethyl)-3-(S)-phenyl-moφholine; 68) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-((3-aminopropyl)- amino carbonylmethyl)-3-(S)-phenylmoφholine; 69) 4-benzyl-5-(S),6-(R)-dimethyl-3-(S)-phenylmoφholinone and 4- benzyl-5-(R),6-(S)-dimethyl-3-(S)-phenyl-moφholinone; 70) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-[5-(S),6-(R) or 5- (R),6-(S)-dimethyl]-3-(S)-phenyl-moφholinone; 71) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-[5-(R),6-(S) or 5- (S),6-(R)-dimethyl]-3-(S)-phenyl-moφholinone; 72) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(l,2,4- triazolo)methyl)-[5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3-(S)- phenyl-moφholinone; 73) 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(5-oxo-lH,4H- 1,2,4-triazolo) methyl)- [5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3- (S)-phenyl-moφholinone; 74) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(l,2,4- triazolo)methyl)-[5-(R),6-(S) or 5-(S),6-(R)-dimethyl]-3-(S)- pheny 1-moφholinone ; 75) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(3-(5-oxo- 1H,4H- l,2,4-triazolo)methyl)-[5-(R),6-(S) or 5-(S),6-(R)-dimethyl]-3- (S)-phenyl-moφholinone; 76) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(2-(l-(4-benzyl)- piperidino)ethyl)-3-(S)-phenyl-moφholine; 77) 3-(S)-(4-fluorophenyl)-4-benzyl-2-moφholinone; 78) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluoro- phenyl)-4-benzyl-moφholine; 79) 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluorophenyl) moφholine; 80) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluoro- phenyl)-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 81) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-((3-pyridyl)methyl carbonyl)-3-(R)-phenyl-moφholine; 82) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(methoxycarbonyl- pentyl)-3-(R)-phenyl-moφholine; 83) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(carboxypentyl)-3- (R)-phenyl-moφholine; 84) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-4-(methylamino- carbonylpentyl)-6-oxo-hexyl)-3-(R)-phenyl-moφholine; 85) 2-(R)-(3,5-bis(trifluoromethyl)benzoyloxy)-3-(S)-phenyl-4- benzy 1-moφholine ; 86) 2-(R)-(l-(3,5-bis(trifluoromethyl)phenyl)ethenyloxy)-3-(S)- phenyl-4-benzyl-moφholine; 87) 2-(R)-(l-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 88) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 89) 2-(R)-(l-(S)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 90) 2-(R)-(l -(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 91) 2-(R)-(3,5-bis(trifluoromethyl)benzoyloxy)-3-(S)-(4-fluoro)- pheny 1-4-benzyl-moφholine ; 92) 2-(R)-(l-(3,5-bis(trifluoromethyl)phenyl)ethenyloxy)-3-(S)-(4- fluoro)phenyl-4-benzyl-moφholine; 93) 2-(R)-( 1 -(S)-(3 ,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 94) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine ; 95) 2-(R)-(l-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl- moφholine; 96) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 97) 2-(R)-(l-(R)-(l-(3-(methyl).naphthyl))ethoxy)-3-(S)-phenyl-4-(3- ( 1 ,2,4-triazoio)methyl-moφholine; 98). 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl-moφholine; 99) 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-moφholine; 100) 2-(R)-( 1 -(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 101) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-moφholine; 102) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 103) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 104) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 105) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 106) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 107) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 108) 2-(R)-(l-(R) ' -(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 109) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 110) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 111) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 112) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 113) 2-(R)-(l-(R)-(3-(isopropoxy)-5-trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-moφholine; 114) 2-(R)-(l-(R)-(3-(isopropoxy)-5-trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 115) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- pheny 1-moφholine ; 116) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 117) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-moφholine ; 118) 2-(R)-( 1 -(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy )-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 119) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 120) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ; 3 -imidazolo)methyl)-moφholine ; 121) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 122) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 123) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S )-phenyl-moφholine ; 124) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 125) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 126) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 127) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- pheny 1-moφholine ; 128) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 129) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-moφholine; 130) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- * moφholine; 131) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-chloro)phenyl)ethoxy)- 3 -(S)-phenyl-moφholine ; 132) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-chloro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 133) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 134) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 135) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 136) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 137) 2-(R)-( 1 -(R)-( 1 -(naphthyl)ethoxy)-3-(S)-phenyl-moφholine; 138) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methylmoφholine; 139) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 140) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 141) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 142) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 143) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 144) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 145) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 146) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 147) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- pheny 1-moφholine ; 148) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 149) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-hydroxy)- phenyl-moφholine ; 150) 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-hydroxy)- phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 151) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl- moφholine; 152) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-moφholine; 153) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-moφholine; 154) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 155) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- ( 1 ,2,4-triazolo)methyl)-moφholine; 156) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 157) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 158) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 159) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 160) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 161) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- ρhenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 162) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- morpholine; 163) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 164) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 165) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 166) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 167) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 168) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 169) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-imidazolo)methyl-moφholine; 170) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 171) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 172) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 173) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-imidazolo)methyl-moφholine; 174) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 175) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(5- tetrazolo)methy 1-moφholine ; 176) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 177) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(5-tetrazolo)methyl-moφholine; 178) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 179) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- oxo-5H-pyrrol-4-yl)methyl-moφholine; 180) 2-(S)-(2-fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine ; 181) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 182) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 183) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl- moφholine; 184) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-moφhohne; 185) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl 7 moφholine; 186) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-moφholine; 187) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- ( 1 ,2,4-triazolo)methyl-moφholine; 188) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 189) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 190) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4- (3 - ( 1 ,2 ,4-triazolo)methyl)-moφholine ; 191) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-ρhenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 192) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 193) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- ρhenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 194) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 195) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 196) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 197) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 198) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 199) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-ρhenyl-4-(2- imidazolo)methyl)-moφholine; 200) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl)-moφholine; 201) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-imidazolo)methyl)-moφholine; 202) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(2-imidazolo)methyl)-moφholine; 203) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- imidazolo)methyl)-moφholine; 204) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 205) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-imidazolo)methyl-moφholine; 206) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 207) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(5- . tetrazolo)methyl-moφholine; 208) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 209) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(5-tetrazolo)methyl-moφholine; 210) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 211) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- oxo-5H-pyrrol-4-yl)methyl-moφholine; 212) 2-(S)-(2-chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 213) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 214) 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 215) 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-moφholine; 216) 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 217) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-ρhenyl-moφholine; 218) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 219) 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(3-( 1,2,4- triazolo)methyl)-moφholine ; 220) 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-( 1,2,4- triazolo)methyl)-moφholine; 221 ) 2-(R)-( 1 -(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(3-( 1 ,2,4- triazolo)methyl)-moφholine ; 222) 2-(R)-( 1 -(R)-(3-methyl)phenylethoxy )-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl)-moφholine; 223) 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo- 1,2,4- triazolo)methyl)-moφholine ; 224) 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- l,2,4-triazolo)methyl)-moφholine; 225) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- l,2,4-triazolo)methyl)-moφholine; 226) 2-(R)-( 1 -(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-l,2,4-triazolo)methyl)-moφholine; 227) 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3- imidazolo)methy l)-moφholine ; 228) 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 229) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 230) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 231) 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 232) 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)ρhenyl-4-(2- imidazolo)methyl-moφholine; 233) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 234) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine ; 235) 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 236) 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 237) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 238) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 239) 2-(S)-(3-methyl)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholine; 240) 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)ρhenyl-4-(5- tetrazolo)methyl-moφholine; 241) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methy 1-moφholine ; 242) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-moφholine; 243) 2-(S)-(3-methyl)benzyloxy-3-(S)-ρhenyl-4-(2-oxo-5H-pyrrol-4- yl)methyl-moφholine ; 244) 2-(S)-(3-methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine ; 245) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-y l)methyl-moφholine ; 246) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 247) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-moφholine; 248) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)ρhenyl-moφholine; 249) 2-(R)-( 1 -(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-moφholine; 250) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 251) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 252) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 253) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(3-( 1,2,4- triazolo)methyl-moφholine; 254) 2-(R)-(l-(R)-(3-bromq)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-( 1 ,2,4-triazolo)methyl-moφholine; 255) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo-lH,4H- 1 ,2,4-triazolo)methyl-moφholine; 256) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-moφholine; 257) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 258) 2-(R)-(l-(R)-(3-bromo)ρhenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 259) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3- imidazolo)methyl)-moφholine; 260) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- l,3-imidazolo)methyl)-moφholine; 261) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 262) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 263) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 264) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 265) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 266) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S) ' -(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine; 267) 2-(S)-(3-bromo)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 268) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 269) 2-(R)-( 1 -(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 270) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine ; 271) 2-(S)-(3-bromo)benzyloxy-3-(S)-ρhenyl-4-(5-tetrazolo)methyl- moφholine; 272) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 273) 2-(R)-( 1 -(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine ; 274) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-moφholine; 275) 2-(S)-(3-bromo)benzyloxy-3-(S)-ρhenyl-4-(2-oxo-5H-pyrrol-4- yl)methyl-moφholine; 276) 2-(S)-(3-bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine ; 277) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 278) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 279) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-moφholine; 280) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 281) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-moφholine; 282) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 283) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(3-( 1,2,4- triazolo)methyl)-moφholine; 284) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-( 1,2,4- triazolo)methyl)-moφholine ; 285) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(3-( 1,2,4- triazolo)methyl)-moφholine; 286) 2-(R)-( 1 -(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl)-moφholine; 287) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo- 1H,4H- l,2,4-triazolo)methyl)-moφholine; 288) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 289) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 290) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 291 ) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3- imidazolo)methyl)-moφholine; 292) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 293) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 294) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 295) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 296) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 297) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 298) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine; 299) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφhpline; 300) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 301) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 302) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 303) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholine; 304) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine ; 305) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methy 1-moφholine ; 306) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)ρhenyl-4- (5-tetrazόlo)methyl-moφholine; 307) 2-(S)-(3-chloro)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- yl)methy 1-moφholine ; 308) 2-(S)-(3-chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 309) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine ; 310) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 311) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-moφholine; 312) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl- moφholine; 313) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-ρhenyl- moφholine; 314) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 315) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3-lH,4H- l,2,4-triazolo)methyl-moφholine; 316) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3- 1 H,4H- 1 ,2,4-triazolo)methyl-moφholine; 317) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (3- 1H,4H- 1 ,2,4-triazolo)methyl-moφholine; 318) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 319) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo)- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 320) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 321) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-ρhenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 322) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 323) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 324) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 325) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-ρhenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 326) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 327) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 328) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 329) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (2-imidazolo)methyl-moφholine; 330) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4- (2-imidazolo)methyl-moφholine ; 331) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- imidazolo)methy 1-moφholine ; 332) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 333) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (4-imidazolo)methyl-moφholine; 334) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-^-(4-imidazolo)methyl-moφholine; 335) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 336) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methy 1-moφholine ; 337) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (5-tetrazolo)methyl-moφholine; 338) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 339) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 340) 2-(S)-(3-trifluoromethyl)benzyloxy-3-(S)-(4-fiuoro)ρhenyl-4-(2- oxo-5H-pyrrol-4-yl)methyl-moφholine; 341) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 342) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 343) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-moφholine; 344) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 345) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-moφholine; 346) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 347) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(3-( 1 ,2,4- triazolo)methyl-moφholine; 348) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-( 1,2,4- triazolo)methyl-moφholine; 349) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 350) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3 - ( 1 ,2,4-triazolo)methyl-moφholine ; 351) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo-lH,4H- 1 ,2,4-triazolo)methyl-moφholine; 352) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-moφholine; 353) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 354) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 355) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3- imidazolo)methyl-moφholine; 356) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 357) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 358) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 359) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 360) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-moφholine; 361) 2-(R)-( 1 -(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine ; 362) 2-(R)-( 1 -(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine; 363) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 364) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 365) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 366) 2-(R)-( 1 -(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 367) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholine; 368) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 369) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methyl-moφholine; 370) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-moφholine; 371 ) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- yl)methyl-moφholine; 372) 2-(S)-(3-t-butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine ; 373) 2-(R)-( 1 -(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methy 1-moφholine ; 374) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)ρhenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 375) 4-(4-(imidazolo)methyl)-2-(3-(tert-butyl)-5-(trifluoromethyl)- benzyloxy)-3-phenyl-moφholine; 376) 2-(R)-(2,5-bis(trifluoromethyl)benzoyloxy)-3-(S)-(4- fluorophenyl)-4-benzyl-moφholine; 377) 2-(R)-( 1 -(2,5-bis(trifluoromethyl)phenyl)ethenyloxy)-3-(S)-(4- fluorophenyl)-4-benzyl-moφholine; 5 378) 2-(R)-(l-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-moφholine; 379) 2-(R)-(l-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- ° fluorophenyl)-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 380) 2-(R)-(l-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 5 381) 2-(R)-(l-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 382) 2-(R)-(l-(R)-(3-(thiomethyl)phenyl)ethoxy)-3-(S)-phenyl- o moφholine; 383) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 384) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(3- ( 1 ,2,4-triazolo)methyl)-moφholine; 385) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo- 1 ,3-imidazolo)methyl)-moφholine; 386) 2-(R)-(l-(R)-(3-(thiomethyl)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-moφholine ; 387) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 388) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 389) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 390) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyl-moφholine; 391) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 392) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyl-4-(3-( 1 ,2,4- triazolo)methyl)-moφholine ; 393) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-l,3- imidazolo)methyl)-moφholine ; 394) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 395) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine ; 396) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 397) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 398) 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)-ethoxy)-3- (S)-(4-fluorophenyl)-moφholine; 399) 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluorophenyl)-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 400) 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluorophenyl)-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 401) 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluorophenyl)-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 402) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)phenyl)-ethoxy)-3- (S)-(4-fluorophenyl)-moφholine; 403) 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 404) 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 405) 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 406) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-moφholine; 407) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 408) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 409) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyϊ-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 410) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 411) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 412) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 413) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)ρhenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 414) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 415) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 416) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)pheny 1-4- (3 -( 1 ,2 ,4-triazolo)methyl)-moφholine ; 417) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 418) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 419) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 42Q) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-mθφholine; 421) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 422) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 423) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 424) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 425) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 426) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-moφholine; 427) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4- triazolo)methyl)-moφholine ; 428) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)ρhenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 429) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 430) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 431) 2-(R)-(l-(R)-(3-(chlθro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 432) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 433) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 434) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 435) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 436) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 437) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 438) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 439) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 440) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 441) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 442) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-moφholine; 443) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 444) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 445) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 446) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 447) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 448) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 449) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 450) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 451) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφhθline; 452) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 453) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 454) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-morpholine; 455) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4- triazolo)methyl)-moφholine; 456) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 457) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 458) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-moφholine; 5 459) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1H,4H- 1,2,4- triazolo)methy l)-moφholine ; 460) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 0 3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 461) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 5 462) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 463) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- ° fflluuoorroo))pphheennyyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 464) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 465) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 466) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)pheny 1-morpholine ; 467) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 468) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 469) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 470) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 471) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 472) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3- (l,2,4-triazolo)methyl)-morpholine; 473) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 474) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 475) 2-(R)-( 1 -(R)-( 1 -(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 476) 2-(R)-( 1 -(R)- ( 1 -(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)pheny 1-4- (3 - ( 1 ,2 ,4-triazolo)methyl)-moφholine ; 477) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 478) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)pheny 1-morpholine ; 479) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 480) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4 τ triazolo)methyl)-moφholine; 481) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 482) 2-(R)-( 1 -(R)-( 1 -(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)pheny 1-morpholine; 483) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 484) 2-(R)-( 1 -(R)-( 1 -(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 485) 2-(R)-( 1 -(R)-( 1 -(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 486) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 487) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 488) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)pheny 1-4- (3 - ( 1 ,2 ,4-triazolo)methy l)-moφholine ; 489) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 490) 2-(R)-(l 7 (R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 491) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine 492) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 493) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 494) 2-(R)-(l-(R)-(3-(thiomethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 495) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)ρhenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 496) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethbxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 497) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 498) 2-(R)-(l-(R)-(3-(thiomethyl)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-moφholine; 499) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4- triazolo)methyl)-moφholine; 500) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 501) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-flUoro)ρhenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 502) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-moφholine; 503) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφholine; 504) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4- triazolo)methyl)-morpholine; 505) 2-(R)-( 1 -(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-l,3- imidazolo)methy l)-moφholine ; 506) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 507) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 508) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 509) 2-(R)-(l-(R)- ' (3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 510) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-moφholine; 511) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-lH,4H- l,2,4-triazolo)methyl)-moφholine; 512) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl)-morpholine; 513) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-l,3- imidazolo)methyl)-moφholine; 514) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl moφholine; 515) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5- oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 516) 2-(R)-( 1 -(R)-(pheny Dethoxy )-3-(S)-(4-fluoro)phenyl-4-(3-( 1 ,2,4- triazolo)methy l)-moφholine ; 517) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2- oxo- 1 ,3-imidazolo)methyl)-moφholine ; 518) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-moφholine; 519) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- ° oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 520) 2-(R)-( l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-( 1,2,4- triazolo)methy l)-moφholine ; 5 521) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl)-moφholine; 522) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 0 523) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 524) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- 5 (3-(l,2,4-triazolo)methyl)-morpholine; 525) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 0 526) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-moφholine; 527) 2-(R)-( 1 -(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo- 1H,4H-1 ,2,4-triazolo)methyl)-moφholine; 528) 2-(R)-( l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-( 1,2,4- triazolo)methy l)-moφholine ; 529) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo- 1 ,3-imidazolo)methyl)-moφholine; 530) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 531) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 532) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl)-morpholine; 533) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 534) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phehyl-morpholine ; 535) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 536) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 537) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 538) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)pheny 1-morpholine ; 539) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)ρhenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 540) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 541) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 542) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-moφholine ; 543) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 544) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 545) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 546) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-moφholine ; 547) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)ρhenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 548) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 549) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 550) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methy lenedioxy pheny 1-moφholine ; 551) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 552) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 553) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 554) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-moφholine; 555) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 556) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(3-(l,2,4-triazolo)methyl)-moφholine; 557) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(4-(2-oxo-l,3-imidazolo)methyl)-moφholine; 558) 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 559) 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 560) 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 561) 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 562) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-morpholine; 563 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 564) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(l,2,4-triazolo)methyl)-morpholine; 565) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 566) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)e ' thoxy)-3-(S)-phenyl- 4-(3-(- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 567) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 568) 2-(R)-( 1 -(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 569) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 570) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 571) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 572) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 573) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 574) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 575) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 576) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 577) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 578) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 579) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 580) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 581) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 582) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 583) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 584) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 585) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 586) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(- 1H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 587) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 588) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(-lH,4H-l,2,4-triazolo)methyl)-moφholine; 589) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)ρhenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 590) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 591) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo- 1 ,3-imidazolo)methyl)-moφholine; 592) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 593) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl)-moφholine; 594) 2-(R)-( 1 -(R)-( 1 -(naphthyl)ethoxy)-3-(S)-phenyl-4-(3-( 1 ,2,4- triazolo)methyl)-moφholine; 595) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-l,3- imidazolo)methyl)-moφholine; 596) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 597) 2-(R)-( 1 -(R)-( 1 -(4-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 598) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-moφholine; 599) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 600) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- ( 1 ,2,4-triazolo)methyl)-moφholine; 601) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-morpholine; and pharmaceutically acceptable salts thereof. Representative examples of the nomenclature employed herein are given below: 439) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 449) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; N^NH 468) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; TACHYKININ ANTAGONISM ASSAY The compounds of this invention are useful for antagonizing tachykinins, in particular substance P and neurokinin A in the treatment of gastrointestinal disorders, central nervous system disorders, inflammatory diseases, pain or migraine and asthma in a mammal in need of such treatment. This activity can be demonstrated- by the following assays. A. Receptor Expression in COS To express the cloned human neurokinin- 1 receptor (NKIR) transiently in COS, the cDNA for the human NKIR was cloned into the expression vector pCDM9 which was derived from pCDM8 (INVITROGEN) by inserting the ampicillin resistance gene (nucleotide 1973 to 2964 from BLUESCRIPT SK+) into the Sac II site. Transfection of 20 ug of the plasmid DNA into 10 million COS cells was achieved by electroporation in 800 ul of transfection buffer (135 mM NaCl, 1.2 mM CaCl2, 1.2 mM MgCl2, 2.4 mM K2HPO4, 0.6 mM KH2PO4, 10 mM glucose, 10 mM HEPES pH 7.4) at 260 V and 950 uF using the IBI GENEZAPPER (IBI, New Haven, CT). The cells were incubated in 10% fetal calf serum, 2 mM glutamine, lOOU/ml penicillin- streptomycin, and 90% DMEM media (GIBCO, Grand Island, NY) in 5% Cθ2 at 37 °C for three days before the binding assay. B. Stable Expression in CHO To establish a stable cell line expressing the cloned human NKIR, the cDNA was subcloned into the vector pRcCMV (INVITROGEN). Transfection of 20 ug of the plasmid DNA into CHO cells was achieved by electroporation in 800 ul of transfection buffer suplemented with 0.625 mg/ml Herring sperm DNA at 300 V and 950 uF using the IBI GENEZAPPER (IBI). The transfected cells were incubated in CHO media [10 % fetal calf serum, 100 U/ml pennicilin- streptomycin, 2 mM glutamine, 1/500 hypoxanthine-thymidine (ATCC), 90% IMDM media (JRH BIOSCIENCES, Lenexa, KS), 0.7 mg/ml G418 (GIBCO)] in 5% Cθ2 at 37°C until colonies were visible. Each colony was separated and propagated. The cell clone with the highest number of human NKIR was selected for subsequent applications such as drug screening. C. Assay Protocol using COS or CHO The binding assay of human NKIR expressed in either COS or CHO cells is based on the use of 125l-substance P (125I-SP, from DU PONT, Boston, MA) as a radioactively labeled ligand which competes with unlabeled substance P or any other ligand for binding to the human NKIR. Monolayer cell cultures of COS or CHO were dissociated by the non-enzymatic solution (SPECIALTY MEDIA, Lavallette, NJ) and resuspended in appropriate volume of the binding buffer (50 mM Tris pH 7.5, 5 mM MnCl2, 150 mM NaCl, 0.04 mg/ml bacitracin, 0.004 mg/ml leupeptin, 0.2 mg/ml BSA, 0.01 mM phosphoramidon) such that 200 ul of the cell suspension would give rise to about 10,000 cpm of specific 125I-SP binding (approximately 50,000 to 200,000 cells). In the binding assay, 200 ul of cells were added to a tube containing 20 ul of 1.5 to 2.5 nM of 125I-SP and 20 ul of unlabeled substance P or any other test compound. The tubes were incubated at 4°C or at room temperature for 1 hour with gentle shaking. The bound radioactivity was separated from unbound radioactivity by GF/C filter (BRANDEL, Gaithersburg, MD) which was pre-wetted with 0.1 % polyethylenimine. The filter was washed with 3 ml of wash buffer (50 mM Tris pH 7.5, 5 mM MnCl2, 150 mM NaCl) three times and its radioactivity was determined by gamma counter. The activation of phospholipase C by NKIR may also be measured in CHO cells expressing the human NKIR by determining the accumulation of inositol monophosphate which is a degradation product of IP3* CHO cells are seeded in 12-well plate at 250,000 cells per well. After incubating in CHO media for 4 days, cells are loaded with 0.025 uCi/ml of 3H-myoinositol by overnight incubation. The extracellular radioactivity is removed by washing with phosphate buffered saline. LiCl is added to the well at final concentration of 0.1 mM with or without the test compound, and incubation is continued at 37°C for 15 min. Substance P is added to the well at final concentration of 0.3 nM to activate the human NKIR. After 30 min of incubation at 37°C, the media is removed and 0.1 N HCl is added. Each well is sonicated at 4°C and extracted with CHCl3/methanol (1:1). The aqueous phase is applied to a 1 ml Dowex AG 1X8 ion exchange column. The column is washed with 0.1 N formic acid followed by 0.025 M ammonium formate-0.1 N formic acid. The inositol monophosphate is eluted with 0.2 M ammonium formate-0.1 N formic acid and quantitated by beta counter. The activity of the present compounds may also be demonstrated by the assay disclosed by Lei, et al., British J. Pharmacol.. 105, 261-262 (1992). The compounds of the present invention are useful in the prevention and treatment of a wide variety of clinical conditions which are characterized by the presence of an excess of tachykinin, in particular substance P, activity. These conditions may include disorders of the central nervous system such as anxiety, depression, psychosis and schizophrenia; epilepsy; neurodegenerative disorders such as dementia, including senile dementia of the Alzheimer type, Alzheimer's disease and Down's syndrome; demyelinating diseases such as multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease) and other neuropathological disorders such as peripheral neuropathy, for example AIDS related neuropathy, diabetic neuropathy, chemotherapy- induced neuropathy, and postheφetic and other neuralgias; small cell carcinomas such as small cell lung cancer; respiratory diseases, particularly those associated with excess mucus secretion, such as chronic obstructive airways disease, bronchopneumonia, chronic bronchitis, acute bronchitis, diifuse panbronchilitis, emphysema, cystic fibrosis, asthma, and bronchospasm; airways disease modulated by neurogenic inflammation; laryngopharhngitis; bronchiectasis; conoisis; whooping cough; pulmonary tuberculosis; diseases associated with decreased glandular secretions, including lacrimation, such as Sjogren's syndrome, hyperlipoproteinemias IV and V, hemochromatosis, sarcoidosis, or amyloidosis; iritis; inflammatory diseases such as inflammatory bowel disease, inflammatory intestinal disease, psoriasis, fibrositis, ocular inflammation, osteoarthritis, rheumatoid arthritis, pruritis, and sunburn; hepatitis; allergies such as eczema and rhinitis; hypersensitivity disorders such as poison ivy; ophthalmic diseases such as conjunctivitis, vernal conjunctivitis, dry eye syndrome, and the like; ophthalmic conditions associated with cell proliferation such as proliferative vitreoretinopathy; cutaneous diseases such as contact dermatitis, atopic dermatitis, urticaria, and other eczematoid dermatitis; hemodialy sis-associated itching; lichen planus; oedema, such as oedema caused by thermal injury; addiction disorders such as alcoholism; mental disease, particularly anxiety and depression; stress related somatic disorders; reflex sympathetic dystrophy such as shoulder/hand syndrome; dysthymic disorders; tenalgia attended to hyperlipidemia; postoperative neuroma, particularly of mastectomy; vulvar vestibulitis; adverse immunological reactions such as rejection of transplanted tissues and disorders related to immune enhancement or suppression, such as systemic lupus erythmatosus; gastrointestinal (GI) disorders and diseases of the GI tract such as disorders associated with the neuronal control of viscera such as ulcerative colitis, Crohn's disease, irritable bowel syndrome, nausea, and emesis, including acute, delayed, post-operative, late-phase, and anticipatory emesis, such as emesis or nausea induced by for example chemotherapy, radiation, surgery, migraine, toxins, such as metabolic or microbial toxins, viral or bacterial infections, pregnancy, vestibular disorder, motion, mechanical stimulation, gastrointestinal obstruction, reduced gastrointestinal motility, visceral pain, psychological stress or disturbance, high altitude, weightlessness, opioid analgesics, intoxication, resulting for example from consumption of alcohol, and variations in intercranial pressure, in particular, for example, drug or radiation induced emesis or post-operative nausea and vomiting; disorders of bladder function such as cystitis, bladder detrusor hyperreflexia, and incontinence; fibrosing and collagen diseases such as scleroderma and eosinophilic fascioliasis; disorders of blood flow caused by vasodilation and vasospastic diseases such as angina, migraine and Reynaud's disease; and pain or nociception, for example, chronic pain or that attributable to or associated with any of the foregoing conditions especially the transmission of pain in migraine, or such as headache, toothache, cancerous pain, back pain, and superficial pain on congelation, burn, heφes zoster or diabetic neuropathy. Hence, these compounds may be readily adapted to therapeutic use for the treatment of physiological disorders associated with an excessive stimulation of tachykinin receptors, especially neurokinin- 1, and as neurokinin- 1 antagonists in the control and/or treatment of any of the aforesaid clinical conditions in mammals, including humans. The compounds of the present invention are also of value in the treatment of a combination of the above conditions, in particular in the treatment of combined post-operative pain and post-operative nausea and vomiting. The compounds of the present invention are particularly useful in the treatment of nausea or emesis, including acute, delayed, post-operative, late-phase, and anticipatory emesis, such as emesis or nausea induced by for example chemotherapy, radiation, surgery, migraine, toxins, such as metabolic or microbial toxins, viral or bacterial infections, pregnancy, vestibular disorder, motion, mechanical stimulation, gastrointestinal obstruction, reduced gastrointestinal motility, visceral pain, psychological stress or disturbance, high altitude, weightlessness, opioid analgesics, intoxication, resulting for example from consumption of alcohol, and variations in intercranial pressure. Most especially, this compound is of use in the treatment of emesis induced by antineoplastic (cytotoxic) agents including those routinely used in cancer chemotherapy. Examples of such chemotherapeutic agents include alkylating agents, for example, nitrogen mustards, ethyleneimine compounds, alkyl sulfonates and other compounds with an alkylating action such as nitrosoureas, cisplatin, and dacarbazine; antimetabolites, for example, folic acid, purine or pyrimidine antagonists; mitotic inhibitors, for example, vinca alkaloids and derivatives of podophyllotoxin; and cytotoxic antibiotics. Particular examples of chemotherapeutic agents are described, for example, by D. J. Stewart in "Nausea and Vomiting: Recent Research and Clinical Advances", Eds. J. Kucharczyk, et aL, CRC Press Inc., Boca Raton, Florida, USA (1991), pages 177-203, especially page 188. Commonly used hemotherapeutic agents include cisplatin, dacarbazine (DTIC), dactinomycin, mechlorethamine (nitrogen mustard), streptozocin, cyclophosphamide, carmustine (BCNU), lomustine (CCNU), doxorubicin (adriamycin), daunorubicin, procarbazine, mitomycin, cytarabine, etoposide, methotrexate, 5- fluorouracil, vinblastine, vincristine, bleomycin, and chlorambucil [R. J. Gralla. et al.. Cancer Treatment Reports. 68(1), 163-172 (1984)]. The compounds of the present invention are also of use in the treatment of emesis induced by radiation including radiation therapy such as in the treatment of cancer, or radiation sickness, and in the treatment of post-operative nausea and vomiting. The compounds of the present invention are also of use in the prevention or treatment of disorders of the central nervous system such as anxiety, psychosis and schizophrenia; neurodegenerative disorders such as senile dementia of the Alzheimer type, Alzheimer's disease and Down's syndrome; respiratory diseases, particularly those associated with excess mucus secretion, such as chronic obstructive airways disease, broncho-pneumonia, chronic bronchitis, cystic fibrosis and asthma, and bronchospasm; inflammatory diseases such as inflammatory bowel disease, osteoarthritis and rheumatoid arthritis; adverse immunological reactions such as rejection of transplanted tissues; gastrointestinal (GI) disorders and diseases of the GI tract such as disorders associated with the neuronal control of viscera such as ulcerative colitis, Crohn's disease and incontinence; disorders of blood flow caused by vasodilation; and pain or nociception, for example, that attributable to or associated with any of the foregoing conditions or the transmission of pain in migraine (both prophylaxis and acute treatment). As calcium channel blocking agents the compounds of the present invention are useful in the prevention of treatment of clinical conditions which benefit from inhibition of the transfer of calcium ions across the plasma membrane of cells. These include diseases and disorders of the heart and vascular system such as angina pectoris, myocardial infarction, cardiac arrhythmia, cardiac hypertrophy, cardiac vasospasm, hypertension, cerebrovascular spasm and other ischemic disease. Furthermore, these compounds may be capable of lowering elevated intraocular pressure when administered topically to the hypertensive eye in solution in a suitable ophthalmic vehicle. Also, these compounds may be useful in the reversal of multidrug resistance in tumor cells by enhancing the efficacy of chemotherapeutic agents. In addition, the compounds may have activity in blocking calcium channels in insect brain membranes and so may be useful as insecticides. The compounds of the present invention are particularly useful in the treatment of pain or nociception and/or inflammation and disorders associated therewith such as, for example: neuropathy, such as diabetic or peripheral neuropathy and chemotherapy-induced neuropathy; postheφetic and other neuralgias; asthma; osteoarthritis; rheumatoid arthritis; and especially migraine. The compounds of the present invention are also particularly useful in the treatment of diseases characterized by neurogenic mucus secretion, especially cystic fibrosis. In the treatment of the clinical conditions noted above, the compounds of this invention may be utilized in compositions such as tablets, capsules or elixirs for oral administration, suppositories for rectal administration, sterile solutions or suspensions for parenteral or intramuscular administration, and the like. The pharmaceutical compositions of this invention may be used in the form of a pharmaceutical preparation, for example, in solid, semisolid or liquid form, which contains one or more of the compounds of the present invention, as an active ingredient, in admixture with an organic or inorganic carrier or excipient suitable for external, enteral or parenteral applications. The active ingredient may be compounded, for example, with the usual non- toxic, pharmaceutically acceptable carriers for tablets, pellets, capsules, suppositories, solutions, emulsions, suspensions, and any other form suitable for use. The carriers which can be used are water, glucose, lactose, gum acacia, gelatin, mannitol, starch paste, magnesium trisilicate, talc, corn starch, keratin, colloidal silica, potato starch, urea and other carriers suitable for use in manufacturing preparations, in solid, semisolid, or liquid form, and in addition auxiliary, stabilizing, thickening and coloring agents and perfumes may be used. The active object compound is included in the pharmaceutical composition in an amount sufficient to produce the desired effect upon the process or condition of the disease. For preparing solid compositions such as tablets, the principal active ingredient is mixed with a pharmaceutical carrier, e.g. conventional tableting ingredients such as corn starch, lactose, sucrose, sorbitol, talc, stearic acid, magnesium stearate, dicalcium phosphate or gums, and other pharmaceutical diluents, e.g. water, to form a solid preformulation composition containing a homogeneous mixture of a compound of the present invention, or a non-toxic pharmaceutically acceptable salt thereof. When referring to these preformulation compositions as homogeneous, it is meant that the active ingredient is dispersed evenly throughout the composition so that the composition may be readily subdivided into equally effective unit dosage forms such as tablets, pills and capsules. This solid preformulation composition is then subdivided into unit dosage forms of the type described above containing from 0.1 to about 500 mg of the active ingredient of the present invention. The tablets or pills of the novel composition can be coated or otherwise compounded to provide a dosage form affording the advantage of prolonged action. For example, the tablet or pill can comprise an inner dosage and an outer dosage component, the latter being in the form of an envelope over the former. The two components can be separated by an enteric layer which serves to resist disintegration in the stomach and permits the inner component to pass intact into the duodenum or to be delayed in release. A variety of materials can be used for such enteric layers or coatings, such materials including a number of polymeric acids and mixtures of polymeric acids with such materials as shellac, cetyl alcohol and cellulose acetate. The liquid forms in which the novel compositions of the present invention may be incoφorated for administration orally or by injection include aqueous solution, suitably flavoured syrups, aqueous or oil suspensions, and emulsions with acceptable oils such as cottonseed oil, sesame oil, coconut oil or peanut oil, or with a solubilizing or emulsifying agent suitable for intravenous use, as well as eljxirs and similar pharmaceutical vehicles. Suitable dispersing or suspending agents for aqueous suspensions include synthetic and natural gums such as tragacanth, acacia, alginate, dextran, sodium carboxymethylcellulose, methylcellulose, polyvinylpyrrolidone or gelatin. Compositions for inhalation or insufflation include solutions and suspensions in pharmaceutically acceptable, aqueous or organic solvents, or mixtures thereof, and powders. The liquid or solid compositions may contain suitable pharmaceutically acceptable excipients as set out above. Preferably the compositions are administered by the oral or nasal respiratory route for local or systemic effect. Compositions in preferably sterile pharmaceutically acceptable solvents may be nebulized by use of inert gases. Nebulized solutions may be breathed directly from the nebulizing device or the nebulizing device may be attached to a face mask, tent or intermittent positive pressure breathing machine. Solution, suspension or powder compositions may be administered, preferably orally or nasally, from devices which deliver the formulation in an appropriate manner. For the treatment of the clinical conditions and diseases noted above, the compounds of this invention may be administered orally, topically, parenterally, by inhalation spray or rectally in dosage unit formulations containing conventional non-toxic pharmaceutically acceptable carriers, adjuvants and vehicles. The term parenteral as used herein includes subcutaneous injections, intravenous, intramuscular, intrasternal injection or infusion techniques. For the treatment of certain conditions it may be desirable to employ a compound of the present invention in conjunction with another pharmacologically active agent. For example, a compound of the present invention may be presented together with another therapeutic agent as a combined preparation for simultaneous, separate, or sequential use for the relief of emesis. Such combined preparations may be, for example, in the form of a twin pack. A preferred combination comprises a compound of the present invention with a chemotherapeutic agent such as an alkylating agent, antimetabolite, mitotic inhibitor, or cytotoxic antibiotic, as described above. In general, the currently available dosage forms of the known therapeutic agents for use in such combinations will be suitable. Similarly, for the treatment of respiratory diseases, such as asthma, a compound of the present invention may be used in conjunction with a bronchodilator, such as a β2-adrenergic receptor agonist or a tachykinin antagonist which acts at neurokinin-2 receptors. Also, for the treatment of conditions that require antagonism of both neurokinin- 1 and neurokinin-2, including disorders associated with bronchoconstriction and/or plasma extravasation in airways, such as asthma, chronic bronchitis, airways disease, or cystic fibrosis, a compound of the present invention may be used in conjunction with a tachykinin antagonist which acts at neurokinin-2 receptors, or with tachykinin receptor antagonist which acts at both neurokinin- 1 and neurokinin-2 receptors. Similarly, for the prevention or treatment of emesis a compound of the present invention may be used in conjunction with other anti-emetic agents, especially 5HT3 receptor antagonists, such as ondansetron, granisetron, tropisetron, decadron, and zatisetron. Likewise, for the prevention or treatment of migraine a compound of the present invention may be used in conjunction with other anti- migraine agents, such as ergotamines or 5HTl agonists, especially sumatriptan. Likewise, for the treatment of behavioral hyperalgesia, a compound of the present invention may be used in conjunction with an antagonist of N-methyl D-aspartate (NMD A), such as dizocilpine. For the prevention or treatment of inflammatory conditions in the lower urinary tract, especially cystitis, a compound of the present invention may be used in conjunction with an antiinflammatory agent, such as a bradykinin receptor antagonist. The compound of the present invention and the other pharmacologically active agent may be administered to a patient simultaneously, sequentially or in combination. The compounds of this invention may be administered to patients (animals and humans) in need of such treatment in dosages that will provide optimal pharmaceutical efficacy. It will be appreciated that the dose required for use in any particular application will vary from patient to patient, not only with the particular compound or composition selected, but also with the route of administration, the nature of the condition being treated, the age and condition of the patient, concurrent medication or special diets then being followed by the patient, and other factors which those skilled in the art will recognize, with the appropriate dosage ultimately being at the discretion of the attendant physician. In the treatment of a condition associated with an excess of tachykinins, an appropriate dosage level will generally be about 0.001 to 50 mg per kg patient body weight per day which may be administered in single or multiple doses. Preferably, the dosage level will be about 0.01 to about 25 mg/kg per day; more preferably about 0.05 to about 10 mg/kg per day. For example, in the treatment of conditions involving the neurotransmission of pain sensations, a suitable dosage level is about 0.001 to 25 mg/kg per day, preferably about 0.05 to 10 mg/kg per day, and especially about 0.1 to 5 mg/kg per day. A compound may be administered on a regimen of 1 to 4 times per day, preferably once or twice per day. In the treatment of emesis using an injectable formulation, a suitable dosage level is about 0.001 to 10 mg/kg per day, preferably about 0.005 to 5 mg/kg per day, and especially about 0.05 to 5 mg/kg per day. A compound may be administered on a regimen of 1 to 4 times per day, preferably once or twice per day. Several methods for preparing the compounds of this invention are illustrated in the following Schemes and Examples wherein Rl, R2, R3, R4, R5, R6, R7, R8, R9, RlO, Rl l, Rl2 and Rl3 are as defined above. ABBREVIATIONS USED IN SCHEMES AND EXAMPLES Table 1 Rea ents: Solvents: SCHEME 1 10 SCHEME 2 XI SCHEME 3 SCHEME4 iPrOH, Δ SCHEME 5 1 SCHEME 6 SCHEME 7 1) LiOH, THF/water 2) H 2 , Pd/C, HOAc/water SCHEME8 °C SCHEME 8 (CONT'D SCHEME 9 S = H 2 or R 1 π 4 4 -CH 2 SCHEME 9 (CONT'D) S = H 2 or R 14 -CH 2 25 30 The compounds of the present invention in which X = Y = O may be prepared by the general route outlined in Scheme 1. Thus, the appropriately substituted α-bromo-phenylacetaldehyde, dimethyl acetal I (prepared using the method of Jacobs in Journal of the American Chemical Society. 1953, 75, 5500) may be converted to the dibenzyl acetal II by stirring I and a slight excess of a benzyl alcohol in the presence of an acid catalyst with concommitant removal of methanol. Alkylation of a substituted amino alcohol by benzyl bromide II may give N-alkyl amino alcohol III; use of a chiral amino alcohol would result in the formation of diastereomers and these may be separated at this (or at a later) stage using standard chromatographic methods. N- Alkylation or N-acylation of III may give the dialkyl- or acyl alkyl-amino alcohol IV in which the group Rl may serve as a protecting group or be used as or laborated into a substituent in the final target compound. Cyclization to give substituted morpholine V may be realized by warming a solution of IV and an acid catalyst. Diastereomers of V that may be formed may be separated using standard chromatographic methods. If Rl is a protecting group, it may be removed using known procedures (Greene, T.W., Wuts, P.G.M. Protective Groups in Organic Synthesis, 2nd ed., John Wiley & Sons, Inc., New York, 1991). If the preparation of I-V results in the formation of enantiomers, these may be resolved by alkylating or acylating V (Rl = H) with a chiral auxiliary, separating the diastereomers thus formed using known chromatographic methods, and removing the chiral auxiliary to give the enantiomers of V. Alternatively, the diastereomers of V may be separated via fractional crystallization from a suitable solvent of the diastereomeric salts formed by V and a chiral organic acid. The compounds of the present invention in which X = O and Y = CH2 may be prepared by the general route outlined in Scheme 2. Thus, the N-methoxy-N-methyl amide of a protected phenyl glycine VI (prepared from the carboxylic acid via the mixed anhydride according to the procedure of Rapoport in Journal of Organic Chemistry. 1985, 50, 3972) may be used to acylate the lithium enolate of methyl diethylphosphonate to give the ketophosphonate VII. The sodium salt of VII may be condensed with an appropriately substituted benzaldehyde to give the α,β-unsaturated ketone VIII. Reduction of the ketone and removal of the t-butylcarbamate protecting group may give amino alcohol IX; diastereomers that may form may be separated at this (or at a later) stage using standard chromatographic techniques. Williamson etherification of IX using a substituted chloroacetate, followed by warming, may result in the formation of morpholinone X. Reduction of the double bond and amide carbonyl may be accomplished in a straightforward manner to give the substituted moφholine XI. If the preparation of VI-XI results in the formation of enantiomers, these may be resolved by alkylating or acylating XI (Rl = H) with a chiral auxiliary, separating the diastereomers thus formed using known chromatographic methods, and removing the chiral auxiliary to give the enantiomers of XI. Alternatively, the diastereomers of XI may be separated via fractional crystallization from a suitable solvent of the diastereomeric salts formed by XI and a chiral organic acid. If it is desired that Rl is other than H, the moφholine nitrogen of XI may be further functionalized using standard methods for the alkylation or acylation of secondary amines. If it is desired that R2 is other than H, moφholinone X may be elaborated into the carbinolcarbamate (Rl = Rθ2C, R2 = OH), an intermediate that could be alkylated and would allow for variation in R2. The compounds of the present invention in which X = S- (O)n (n = 0,1,2) and Y = O may be prepared by the general route outlined in Scheme 3. Thus, alcohol IV (prepared in Scheme 1) may be converted to thioacetate XII using known procedures (Volante, R.P. Tetrahedron Letters, 1981, 22, 3119). Cleavage of the ester moiety to afford thiol XIII may be effected with aqueous base or reductively, depending on the restraints imposed by the other functional groups present. Cyclization of XIII to thiomoφholine XIV may be done by warming a solution of XIII and an acid catalyst. Oxidation of XIV using sodium metaperiodate in acetic acid may afford sulfoxide or sulfone XV. Diastereomers of XIV or XV that may be formed may be separated using standard chromatographic methods. If Rl is a protecting group, it may be removed using known procedures (Greene, T.W., Wuts, P.G.M. Protective Groups in Organic Synthesis, 2nd ed., John Wiley & Sons, Inc., New York, 1991). If the preparation of XII - XV results in the formation of enantiomers, these may be resolved by alkylating or acylating XIV or XV (Rl = H) with a chiral auxiliary, separating the diastereomers thus formed using known chromatographic methods, and removing the chiral auxiliary to give the enantiomers of XIV or XV. Alternatively, the diastereomers of XIV or XV may be separated via fractional crystallization from a suitable solvent of the diastereomeric salts formed by XIV or XV and a chiral organic acid. The compounds of the present invention in which X = Y = O may also be prepared by the general route outlined in Scheme 4. Thus, the appropriately substituted α-bromo-acetaldehyde, dimethyl acetal (prepared using the method of Jacobs in Journal of the American Chemical Society. 1953, 75, 5500) may be converted to the acetal by stirring and a slight excess of the appropriate alcohol in the presence of an acid catalyst with concommitant removal of methanol. Alkylation of a substituted amino alcohol by a bromide may give the N-alkyl amino alcohol; use of a chiral amino alcohol would result in the formation of diastereomers and these may be separated at this (or at a later) stage using standard chromatographic methods. N-Alkylation or N-acylation may give the dialkyl- or acyl/alkyl-amino alcohol in which the group Rl may serve as a protecting group or be used as or elaborated into a substituent in the final target compound. Cyclization to give substituted moφholine may be realized by warming a solution with an acid catalyst. Diastereomers that may be formed may be separated using standard chromatographic methods. If Rl is a protecting group, it may be removed using known procedures (Greene, T.W., Wuts, P.G.M. Protective Groups in Organic Synthesis, 2nd ed., John Wiley & Sons, Inc., New York, 1991). If the preparation of such compounds results in the formation of enantiomers, these may be resolved by alkylating or acylating the final product (Rl = H) with a chiral auxiliary, separating the diastereomers thus formed using known chromatographic methods, and removing the chiral auxiliary to give the desired enantiome :. Alternatively, the diastereomers may be separated via fractional crystallization from a suitable solvent of the diastereomeric salts formed by the compound of a chiral organic acid. One method of synthesizing enantiomerically pure substituted moφholines Illustrated in Scheme 5. Protection of enantiomerically pure phenylglycine as the N-benzyl derivative followed by double alkylation with a 1,2-dibromoethane derivative leads to the moφholinone. Reduction with an active hydride reagent such as diisobutyl aluminum hydride, lithium aluminum hydride, lithium tri(sec-butyl)-borohydride (L-Selectride®) or other reducing agents leads predominantly to the 2,3-trans moφholine derivatives. Alkylation of the alcohol, removal of the protecting group on nitrogen (for example, with a palladium hydrogenation catalyst or with 1-chloroethyl chloroformate (Olofson in J. Org. Chem.. 1984, 2081 and 2795), and alkylation of the nitrogen (wherein RlCH2- or R^CHO = appropriate definitions of JR.1, and LG is an appropriate leaving group) produces the 2,3-trans compounds. One method of producing enantiomerically pure 2,3-cis moφholines is illustrated in Scheme 6. In the first step, formation of the trifluoromethane-sulfonate ester of the appropiate benzyl alcohol (especially benzyl alcohols which are substituted with electron- withdrawing groups such as -N02, -F, -Cl, -Br, -COR, -CF3, etc) is carried out in the presence of an unreactive base, in an inert solvent. Other leaving groups such as iodide, mesylate, tosylate, p-nitrophenyl- sulfonate and the like may also be employed. Appropriate bases include 2,6-di-t-butylpyridine, 2,6-di-t-butyl-4-methyl-pyridine, diisopropyl- ethylamine, potassium carbonate, sodium carbonate, and the like. Suitable solvents include toluene, hexanes, benzene, carbon tetra- chloride, dichloromethane, chloroform, dichloroethane, and the like and mixtures thereof. The filtered solution of the triflate is then added to a solution of the intermediate formed when the moφholinone is contacted with an active hydride reagent such as diisobutyl aluminum hydride, lithium aluminum hydride, or lithium tri(sec-butyl)- borohydride (L- Selectride®) at low temperature, preferably from -78°C to -20°C. After several hours at low temperature, workup and purification provides predominantly 2,3-cis substituted products, which may be carried on to final compounds as shown in Scheme 6. Enantiomerically pure phenylglycines substituted on the phenyl ring may be prepared by the procedure shown in Scheme 7 (D.A. Evans, et al, J. Am. Chem. Soc. 1990. 112, 4011). Methods for preparing the nitrogen alkylating agents RlCH2X used in Scheme 5 and Scheme 6 are based on known literature methods (for Rl = 3-(l,2,4-triazolyl) or 5-(l,2,4-triazol-3-one)-yl and X = Cl, see Yanagisawa, I.; Hirata, Y.; Ishii, Y. Journal of Medicinal Chemistry. 27, 849 (1984); for Rl = 4-((2H)-imidazol-2-one)-yl or 5- (4-ethoxycarbonyl-(2H)-imidazol-2-one)-yl and X = Br, see Ducschinsky, R., Dolan, L.A. Journal of the American Chemical Society. 10., 657 (1948)). One method of producing enantiomerically pure 2,3-cis moφholines that are substituted at the α-position of the C2 benzyl ether is shown in Scheme 8. Thus, a substituted 2-moφholinone (prepared as described in Scheme 5) is reacted with an active hydride reagent, such as diisobutylaluminum hydride, lithium aluminum hydride, or lithium tri(sec-butyl)borohydrdide and the resulting reaction intermediate is quenched with a substituted benzoyl halide, anhydride, or other activated acyl transfer reagent. Aqueous work-up affords the 2-benzoyloxy compound shown in Scheme 8. This compound is converted to the corresponding enol ether using a "titanium ylide" generated from reagents such as μ-chloro-μ-methylene-[bis(cyclo- pentadienyl)titanium]dimethylamluminum ("Tebbe Reagent", Tebbe, F.N., Parshall, G.W., Reddy, G.S., Journal of the American Society. 100. 3611 (1978)), dimethyl titanocene (Petasis, N.A., Bzowej, E.I., Journal of the American Chemical Society. 112. 6392 (1990)) or the reagent prepared by the reduction of 1,1-dibromoalkanes with zinc and titanium tetrachloride in the presence of N,N,N',N'-tetramethyl- ethylenediamine (Takai, K. et.al., Journal of Organic Chemistry. 52. 4412 (1987)), wherein R14-CH2- = Z. The resulting enol ether is reduced to its saturated analog by hydrogenation in the presence of a rhodium based catalyst, such as rhodium on alumina or on carbon; if concomitant removal of the N-benzyl group on the moφholine nitrogen is desired, the hydrogenation may be carried out in the presence of palladium on carbon catalyst. If diastereomers are obtained at this juncture, they may be separated using chromatographic methods or by recrystallization of the mixture of diastereomers. Elaboration of the moφholines so obtained to the final product is carried out in manners analogous to those described in Schemes 5 and 6. Methods by which the substitution on the C-3 phenyl ring of the moφholines of the present invention may be introduced or altered is shown in Scheme 9. Thus, a substituted moφholine may be prepared as described in Scheme 5, 6, or 8 from an enantiomerically pure benzyloxy-substituted aryl glycine (prepared as described in the literature (e.g. L-p-benzyloxyphenylglycine may be prepared according to the procedure of Kamiya, et al. Tetrahedron. 35. 323 (1979)) or using the methods described in Scheme 7). Selective cleavage of the benzyl ether via hydrogenolysis or nonselective hydrogenolysis followed by the synthetic sequence shown in Scheme 9 may afford a suitably protected phenolic intermediate. The phenol may be converted to the corresponding aryl triflate (as shown, or using N-phenyl- trifluoromethane-sulfonimide in the presence of a tertiary amine base in methylene chloride) and the triflate converted to the desired functional group using the palladium- or nickel-catalyzed methods described in Ritter, Synthesis. 735 (1993) (and refs. therein). Elaboration to the desired final product may be carried out as described in Scheme 5 or 6. The object compounds of Formula I obtained according to the reactions as explained above may be isolated and purified in a conventional manner, for example, extraction, precipitation, fractional crystallization, recrystallization, chromatography, and the like. The compounds of the present invention are capable of forming salts with various inorganic and organic acids and bases and such salts are also within the scope of this invention. Examples of such acid addition salts include acetate, adipate, benzoate, benzenesulfonate, bisulfate, butyrate, citrate, camphorate, camphorsulfonate, diphosphate, ethane-sulfonate, fumarate, hemisulfate, heptanoate, hexanoate, hydrochloride, hydrobromide, hydroiodide, 2-hydroxyethylsulfonate, methanesulfonate, lactate, malate, maleate, methanesulfonate, 2- naphthalenesulfonate, nitrate, oxalate, pamoate, persulfate, phosphate, picrate, pivalate, propionate, salicylate, stearate, succinate, sulfate, tartrate, tosylate, and undecanoate. Base salts include ammonium salts, alkali metal salts such as sodium, lithium and potassium salts, alkaline earth metal salts such as calcium and magnesium salts, salts with aluminum or zinc, salts with organic bases such as dicyclohexylamine salts, N-methyl-D-glucamine (meglumine), and salts with amino acids such as arginine, lysine and so forth. Also, the basic nitrogen- containing groups may be quaternized with such agents as: lower alkyl halides, such as methyl, ethyl, propyl, and butyl chloride, bromides and iodides; dialkyl sulfates like dimethyl, diethyl, dibutyl; diamyl sulfates; long chain halides such as decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides; aralkyl halides like benzyl bromide and others. The non-toxic physiologically acceptable salts are preferred, although other salts are also useful, such as in isolating or purifying the product. The salts may be formed by conventional means, such as by reacting the free base form of the product with one or more equivalents of the appropriate acid in a solvent or medium in which the salt is insoluble, or in a solvent such as water which is removed in vacuo or by freeze drying or by exchanging the anions of an existing salt for another anion on a suitable ion exchange resin. Although the reaction schemes described herein are reasonably general, it will be understood by those skilled in the art of organic synthesis that one or more functional groups present in a given compound of formula I may render the molecule incompatible with a particular synthetic sequence. In such a case an alternative route, an altered order of steps, or a strategy of protection and deprotection may be employed. In all cases the particular reaction conditions, including reagents, solvent, temperature, and time, should be chosen so that they are consistent with the nature of the functionality present in the molecule. The following examples are given for the puφose of illustrating the present invention and shall not be construed as being limitations on the scope or spirit of the instant invention. EXAMPLE 1 (+/-)-α-Bromo-phenylacetaldehyde, 3,5-bis(trifluoro-methyl)benzyl acetal A solution of 2.50 g (10.2 mmol) of α-bromo- phenylacetaldehyde, dimethyl acetal, 8.00 g (32.8 mmol) of 3,5- bis(trifluoromethyl)benzyl alcohol and 0.50 g (2.6 mmol) of p- toluenesulfonic acid monohydrate in 10 mL of toluene was stirred under vacuum (35 mmHg) at it for 3 days. The reaction mixture was partitioned between 100 mL of ether and 50 mL of saturated aqueous sodium bicarbonate solution and the layers were separated. The organic layer was washed with 25 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate, and concentrated in vacuo. Flash chromatography on 200 g of silica gel using 9: 1 v/v hexane/methylene chloride as the eluant afforded 5.41 g (81%) of the title compound as a solid, mp 79-82°C: lH NMR 4.47 and 4.62 (AB q, 2 H, J = 12.5), 4.78-4.93 (2 H), 5.09 and 5.21 (AB q, 2 H, J = 7.7), 7.31-7.44 (m, 7 H), 7.70 (app s, 1 H), 7.82 (app s, 1 H), 7.84 (app s 2 H); IR (thin film) 1363, 1278, 1174, 1130, 704, 682. Analysis Calcd for C26Hl7BrFl2θ2* C, 46.76; H, 2.23; Br, 11.64; F, 33.70. Found: C, 46.65; H, 2.56; Br, 11.94; F, 34.06. EXAMPLE 2 (+/-)-N-(2 Hydroxyethyl)-phenylglycinal, 3 ,5-bis-(trifluoromethyl)- benzyl acetal A solution of 1.50 g (2.2 mmol) of (+/-)-α-bromo- phenylacetaldehyde, 3,5-bis(trifluoromethyl)-benzyl acetal (Example 1), 100 mg (0.67 mmol) of sodium iodide and 3 mL of ethanolamine in 6 mL of isopropanol was heated at reflux for 20 h. The solution was cooled and concentrated to -25% the original volume in vacuo. The concentrated solution was partitioned between 50 mL of ether and 20 mL of 2 N aqueous sodium hydroxide solution and the layers were separated. The organic layer was washed with 20 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated in vacuo. Flash chromatography on 50 g of silica gel using 65:35 v/v ether/hexane as the eluant afforded 1.18 g (83%) of the title compound as an oil: lH NMR 2.66 (br s, 2 H), 2.61 and 2.68 (ddAB q, 2 H, JAB = 12.4, J2.61 = 6.8, 6.2, J2.68 = 6.2, 6.2), 3.57 and 3.66 (ddAB q, 2 H, JAB = 10.8, J3.57 = 6.2, 6.2), J3.66 = 6.8, 6.2), 4.02 (d, 1 H, J = 7.0), 4.37 and 4.64 (AB q, 2 H, J = 12.5), 4.80 and 4.87 (AB q, 2 H, J = 12.8), 4.87 (d, 1 H, J = 7.0), 7.31-7.40 (7 H), 7.73 (app s, 1 H), 7.81 (app s, 3 H); IR (neat) 3342, 1456, 1373, 1278, 1173, 1128, 704, 682; FAB-MS 650(M+1)+. Analysis Calcd for C28H23F12NO3: C, 51.78; H, 3.57; N, 2.16; F, 35.11. Found: C, 51.80; H, 3.67; N, 2.10; F, 35.41. EXAMPLE 3 (+/-)-N-(2-Hydroxyethyl)-N-(proρ-2-enyl)-ρhenyl-glycinal, 3,5- bis(trifluoromethyl benzyl acetal A mixture of 1.45 g (2.2 mmol) of (+/-)-N-(2- hydroxyethyl)-phenylglycinal, 3 ,5-bis-(trifluoromethyl)benzyl acetal (Example 2), 1.0 g (7.2 mmol) of potassium carbonate, 3.0 mL (35.0 mmol) of allyl bromide and 15 mL of ethanol was stirred at 60 °C for 20 h. The mixture was cooled, partitioned between 100 mL of ether and 25 mL of water and the layers were separated. The organic layer was dried over magnesium sulfate. The aqueous layer was extracted with 100 mL of ether; the ether extract was dried and combined with the original organic layer. The combined organic layers were concentrated in vacuo. Flash chromatography on 50 g of silica gel using 4:1 v/v hexane/ether as the eluant afforded 1.36 g (88%) of the title compound as an oil: lH NMR 2.40 (dt, 1 H, J = 13.2, 2.8), 2.93- 3.08 (3 H), 3.30 (ddt, 1 H, J = 12.0, 2.8, 1.6), 3.54 (br m, 2 H), 3.65 (dt, 1 H, J = 10.0, 2.8), 4.23 (d, 1 H, J = 8.4), 4.52 and 4.58 (AB q, 2 H, J = 12.4), 4.85 and 4.95 (AB q , 2 H, J = 12.4), 5.25 (d, 1 H, J = 9.6), 5.28 (d, 1 H, J = 16.4), 5.39 (d, 1 H, J = 8.4), 5.81 (m, 1 H), 7.24-7.40 (7 H), 7.68 (s 1 H), 7.83 (s, 1 H), 7.86 (s, 2 H); IR (neat) 3457, 1362, 1278, 1174, 1132, 1056, 759, 705, 682; FAB-MS 690(M+1)+. Analysis Calcd for C31 H27F 12NO3 : C, 53.99; H, 3.95; N, 2.03; F, 33.07. Found: C, 54.11; H, 4.08; N, 1.78; F, 32.75. EXAMPLE 4 (+/-)-2-(3.5-Bis(trifluoromethyl)benzyloxy)-3-phenylmoφholine Step A: A solution of 850 mg (1.2 mmol) of (+/-)-N-(2- hydroxyethyl)-N-(prop-2-enyl)-phenyl-glycinal, 3,5-bis(trifluoro- methyl)benzyl acetal (Example 3) and 700 mg (3.7 mmol) of p- toluenesulfonic acid monohydrate in 15 mL of toluene was heated at reflux for 1.5 h. The reaction mixture was cooled and partitioned between 100 mL of ether and 25 mL of saturated aqueous sodium bicarbonate solution. The layers were separated; the organic layer was washed with 25 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate, and concentrated in vacuo. Flash chromatography on 30 g of silica gel using 50: 1 v/v hexane/ether as the eluant afforded 426 mg (78%) of the N-allyl moφholines which were used in the next step without further purification. Step B: A 50 mL 2-necked flask, equipped with a stopper and a short path distillation apparatus, was charged with a solution of the N- allyl moφholines (Example 4, Step A) (540 mg, 1.2 mmol)) and 80 mg (0.09 mmol) tris(triphenylphosphine)rhodium chloride (Wilkinson's catalyst) in 25 mL of 4:1 v/v acetonitrile/water. The reaction mixture was heated to boiling and solvent was allowed to distill from the reaction mixture. The volume of the reaction mixture was maintained between 10 and 20 mL by adding solvent through the stoppered inlet. After 1 h and 4 h, the reaction was treated with additional 80 mg portions of the Wilkinson's catalyst. After 6 h, the reaction mixture cooled and partitioned between 75 mL of ether and 50 mL of water. The layers were separated and the organic layer was dried over magnesium sulfate. The aqueous layer was extracted with 75 mL of ether; the extract was dried and combined with the original organic layer. The combined organic layers were concentrated in vacuo. Flash chromatography on 35 g of silica gel using 1:1 v/v ether/hexane as the eluant afforded 200 mg of trans-isomer and 130 mg of a mixture of cis- and trans-isomers (68% total). Chromatography of the mixture on 8 g of silica gel using 4: 1 v/v hexane/ether as the eluant afforded 64 mg of cis and 57 mg of a mixture of the cis- and trans-isomers of the title compound. For trans: lH NMR 2.03 (br s, 1 H), 2.94 (ddd, 1 H, J = 11.0, 2.5, 2.5), 3.08 (dt, 1 H, J = 11.0, 3.2), 3.71 (d, 1 H, J = 7.0), 3.83 (dt, 1 H, J = 11.2, 2.8), 4.05 (ddd, 1 H, J = 11.2, 3.2, 3.2), 4.43 (d, 1 H, J = 7.0), 4.53 and 4.88 (AB q, 2 H, J = 13.3), 7.26-7.45 (7 H), 7.70 (s, 1 H); IR (neat) 3333, 2859, 1456, 1374, 1278, 1173, 1131, 1082, 757, 702, 682; FAB-MS 406(M+1)+. Analysis Calcd for C19H17F6NO2: C, 56.30; H, 4.23; N, 3.46; F, 28.12. Found: C, 56.39; H, 4.28; N, 3.36; F, 28.32. For cis: lH NMR 2.10 (br s, 1 H), 3.13 (dd, 1 H, J = 12.4, 3.0), 3.26 (dt, 1 H, J = 12.4, 3.6), 3.65 (dd, 1 H, J = 11.6, 3.6), 4.07 (dt, I H, J = 11.6, 3.0), 4.14 (d, 1 H, J = 2.4), 4.52 and 4.82 (AB q, 2 H, J = 13.6), 4.76 (d, 1 H, J = 2.4), 7.30-7.42 (6 H), 7.70 (s, 1 H), FAB-MS 406(M+1)+* EXAMPLE 5 (+/-)-2-(3,5-Bis(trifluoromethyl)benzyloxy)-3-phenyl-4-methylcarbox- amido morpholine A solution of 105 mg (0.26 mmol) of the trans-isomer of (+/-)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3-phenyl-moφholine (Example 4) and 0.09 mL (0.50 mmol) of N,N-diisopropylethylamine in 3 mL of acetonitrile was treated with 90 mg (0.50 mmol) of iodoacetamide and the resulting solution was stirred at rt for 16 h. The solution was concentrated m vacuo and the residue was partitioned between 20 mL of ethyl acetate and 10 mL of 0.5 N aqueous potassium hydrogen sulfate solution. The layers were separated; the organic layer was washed with 10 mL of 5% aqueous sodium thiosulfate solution, 10 mL of saturated aqueous sodium bicarbonate solution, 10 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated in vacuo. Rash chromatography on 5 g of silica gel using 2:1 v/v ethyl acetate/hexane as the eluant afforded 99 mg (82%) of the trans-isomer of the title compound as an oil: lH NMR 2.56 (dt, 1 H, J = 3.2, 11.6), 2.67 and 3.16 (AB q, 2 H, J = 16.4), 2.96 (dt, 1 H, J = 12.0, 1.6), 3.30 (d, 1 H, J = 7.0), 3.86 (dt, 1 H, J = 3.2, 12.0), 4.08 (ddt, 1 H, J = 11.6, 3.2, 1.6), 4.48 and 4.84 (AB q, 2 H, J = 13.2), 4.49 (d, 1 H, J = 7.0), 5.98 (br s, 1 H), 6.83 (br s, 1 H), 7.33 (app s, 7 H), 7.70 (s, 1 H); IR (neat) 3445, 2838, 1682, 1278, 1173, 1132, 760, 704, 682; FAB-MS 463 (M+l)+. Analysis Calcd for C21 H20F6NO3 : C, 54.54; H, 4.36; N, 6.06; F, 24.65. Found: C, 54.54; H, 4.52; N, 5.61; F, 24.45. A similar experiment was carried out on 40 mg (0.99 mmol) of the cis-isomer of (+/-)-2-(3,5-bis-(trifluoromethyl)- benzyloxy)-3-phenyl-moφholine (Example 4) using 0.035 mL (0.2 mmol) of N,N-diisopropylethylamine and 37 mg (0.2 mmol) of iodoacetamide in the reaction. Work-up and flash chromatography afforded 30 mg (65%) of the cis-isomer of the title compound as an oil: lH NMR 2.54 and 3.04 (AB q , 2 H, J = 16.8), 2.63 (dt, 1 H, J = 3.6, 12.0), 3.04 (d, 1 H, J = 11.6), 3.65 (d, 1 H, J = 2.8), 3.71 (ddt, 1 H, J = 11.6, 3.2, 1.2), 4.21 (dt, 1 H, J = 11.6, 2.4), 4.44 and 4.89 (AB q , 2 H, J = 13.6), 4.71 (d, 1 H, J = 2.8), 5.86 (br s, 1 H), 7.15 (br s, 1 H), 7.27- 7.45 (7 H), 7.73 (s, 1 H); FAB-MS 463(M+1)+. EXAMPLE 6 (* -)-2-(3,5-Bis(trifluoromethyl)benzyloxy)-3-phenyl-4-(methoxy- carbonylmethyPmorpholine A solution of 150 mg.(0.37 mmol) of the trans-isomer of (+/-)-2-(3,5-bis(trifϊuoromethyl)benzyloxy)-3-phenyl moφholine (Example 4) and 0.18 mL (1.00 mmol) of N,N-diisopropyl-ethyl- amine in 2.mL of acetonitrile was treated with 0.095 mL (1.00 mmol) of methyl bromoacetate and the resulting solution was stirred at it for 20 h. The solution was concentrated in vacuo and the residue was partitioned between 20 mL of ethyl acetate and 5 mL of 0.5 N aqueous potassium hydrogen sulfate solution. The layers were separated; the organic layer was washed with 10 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated in vacuo. Flash chromatography on 10 g of silica gel using 4:1 v/v hexanes/ether as the eluant afforded 164 mg (93%) of the trans-isomer of the title compound as an oil: lH NMR 2.79 (dt, 1 H, J = 3.2, 11.2), 2.93 (dt, 1 H, J = 11.2, 1.6), 3.52 (d, 1 H, J = 7.2), 3.63 (s, 3 H), 3.92 (dt, 1 H, J = 2.8, 11.6), 4.04 (ddd, 1 H, J = 11.6, 3.2, 1.6), 4.45 and 4.84 (AB q, 2 H, J = 13.2), 4.46 (d, 1 H, J = 7.2), 7.31 - 7.38 (m, 6 H), 7.68 (s, 1 H); IR (neat) 2861, 1744, 1455, 1375, 1346, 1278, 1170, 887, 759, 704, 682; FAB-MS 478(M+1)+. Analysis Calcd for C22H21 F6NO4: C, 55.35; H, 4.43; N, 2.93; F, 23.88. Found: C, 55.74; H, 4.50; N, 2.79; F, 24.01. EXAMPLE 7 N-Methoxy-N-methyl-(N-t-butoxycarbonyl -phenylglvcinamide A solution of 20.0 g (79.7 mmol) of (N-t-butoxycarbonyl)- phenylglycine in 150 mL of ethyl acetate at -10°C was treated with 8.8 mL (79.7 mmol) of 4-methylmoφholine. Isobutylchloroformate (10.3 mL, 79.7 mmol) was added dropwise over 10 minutes maintaining the temperature at -10°C; the resulting suspension was stirred cold for 15 min. The mixture was treated with 11.6 g (119.0 mmol) of N,0- Dimethyl-hydroxylamine • HCl. A second portion of 4-methyl- moφholine (13.0 mL, 119.0 mmol) was added and the reaction was stirred at -10°C for 15 min and at 25°C for 2 h. The reaction mixture was partitioned between 100 mL of ethyl acetate and 100 mL of 10% aqueous citric acid solution and the layers were separated. The organic layer was washed with 100 mL of saturated aqueous sodium bicarbonate solution, 100 mL of saturated aqueous ammonium chloride solution, dried over magnesium sulfate and concentrated in vacuo. Crystallization from hexanes at -20°C for 72 h afforded 8.0 g (34%) of the title compound as a solid: lH NMR 1.40 (s, 9 H), 3.20 (s, 3 H), 3.40 (s, 3 H), 5.80 (m, 2 H), 7.40 (m, 5 H). EXAMPLE 8 Diethyl (2-oxo-3-t-butoxycarbamido-3-phenyl -propylphosphonate A solution of 7.45 mL (51.0 mmol) of diethyl methylphosphonate in tetrahydrofuran at -78°C was treated with 31.8 mL (51.0 mmol) of 1.6 M n-butyllithium in hexanes solution and the resulting mixture was stirred cold for 30 min. A solution of 4.0 g (14.0 mmol) of N ethoxy-N-methyl-(N-t-butoxycarbonyl)phenyl- glycinamide (Example 7) in 20 mL of tetrahydrofuran was added and the reaction was stirred at -78°C for 15 min and at 25°C for 15 min. The reaction was quenched with 150 mL of saturated aqueous ammonium chloride solution, diluted with 300 mL of ethyl acetate, and the layers were separated. The organic layer was dried over magnesium sulfate and concentrated in vacuo. Flash chromatography on silica gel using 7:3 v/v then 4:1 v/v ethyl acetate/hexanes as the eluant afforded 4.8 g (92%) of the title compound as an oil: lH NMR 1.20- 1.42 (15 H), 2.84 (dd, 1 H), 3.20 (dd, 1 H), 4.00-4.20 (m, 4 H), 5.50 (d, 1 H), 5.94 (br s, 1 H), 7.32 (m, 5 H). EXAMPLE 9 N-t-Butoxycarbonyl-l-phenyl-2-oxo-4-(3,5-bis(tri-fluoromethyl)- phenyl)-but-3-enamine A solution of 4.80 g (12.5 mmol) of diethyl (2-oxo-3-t- butoxycarbamido-3-phenyl)propylphosphonate (Example 8) in 20 mL of THF was added dropwise to a suspension of 1.05 g (26.3 mmol, 60% dispersion in mineral oil) of sodium hydride in 30 mL of tetrahydrofuran at 0°C. After 15 min, 2.06 mL (12.5 mmol) of 3,5- bis(trifluoromethyl)benzaldehyde was slowly added and the resulting mixture was stirrred cold for 15 min. The reaction was quenched with 50 mL of saturated aqueous ammonium chloride solution, diluted with 50 mL of ethyl acetate, and the layers were separated. The organic layer was dried over magnesium sulfate and concentrated in vacuo. Flash chromatography on silica gel using 19:1 v/v, then 9:1 v/v ethyl acetate/petroleum ether as the eluant afforded 3.30 g (56%) of the title compound as a solid: lH NMR 1.40 (s, 9 H), 5.38 (d, 1 H), 5.90 (d, 1 H), 6.80 (d, 1 H), 7.39 (m, 5 H), 7.70 (s, 1 H), 7.84 (s, 3 H). EXAMPLE 10 l-Phenyl-2-hydroxy-4-(3,5-bis(trifluoromethyl)phenyl)-but-3-enamine ■ HCl A solution of 1.00 g ( 2.1 jmmol) of N-t-butoxycarbonyl-1- phenyl-2-oxo-4-(3,5-bis(trifluoromethyl)phenyl)-but-3-enamine (Example 8) in 30 mL of methanol at 0°C was treated with 241 mg (6.3 mmol) of sodium borohydride. After 30 min, the reaction was quenched with 50 mL of water and concentrated in vacuo to remove the methanol. The mixture was partitioned between 100 mL of ethyl acetate and 50 mL of water and the layers were separated. The organic layer was dried over magnesium sulfate and concentrated in vacuo. Crystallization from ether/hexanes afforded 680 mg (68%) of the title compound as a 5:1 mixture of diastereomers (each protected as the t- butylcarbamate): lH NMR (* indicates the resonances of the minor diastereomer) 1.40 (s, 9 H), 4.60 (dd, 1 H), 4.90 (br s, 1 H), 5.20 (br d, 1 H), 6.30 (dd, 1 H), 6.40 (dd. 1 H*), 6.70 (dd, 1 H), 6.80 (dd, 1 H*), 7.40 (m, 5 H), 7.80 (m, 3 H). A solution of BOC-protected title compound in methanol (saturated with HCl) was allowed to stand for 72 h. The solution was concentrated in vacuo. Recrystallization of the resulting solid from ether/hexane afforded 500 mg (80%) of the title compound • HCl as a solid: lH NMR 4.20 (br s, 1 H), 4.40 (d, 1 H), 6.20 (dd, 1 H), 6.60 (dd, 1 H), 7.30 (m 5 H), 7.80 (m, 3 H). * The title compound • HCl was dissolved in ethyl acetate and 1 N aqueous sodium hydroxide solution. The layers were separated; the organic layer was dried over magnesium sulfate and concentrated in vacuo to afford the title compound as the free base. EXAMPLE 11 2-(2-(3,5-Bis(trifluoromethyl)phenyl)ethenyl)-3-phenyl-5-oxo- morpholine A solution of 1.95 g (5.2 mmol) of l-phenyl-2-hydroxy-4- (3,5-bis(trifluoromethyl)ρhenyl)-but-3-enamine (Example 10) in 20 mL of toluene was added to a suspension of 250 mg (6.2 mmol, 60% dispersion in mineral oil) of sodium hydride in 30 mL of toluene and the resulting mixture was stirred at it for 15 min. A solution of 0.60 mL (1.15 mol) of ethyl chloroacetate in 5 mL of toluene was slowly added and the resulting mixture was heated at reflux for 3 h. The reaction was cooled, quenched with 50 mL of saturated aqueous ammonium chloride solution, diluted with 50 mL of ethyl acetate and the layers were separated. The organic layer was dried over magnesium sulfate and concentrated in vacuo. Flash chromatography using ethyl acetate/hexanes (4:1 v/v, then 3:1 v/v, then 1:1 v/v) then ethyl acetate as the eluant afforded 300 mg of trans-title compound and 800 mg of cis-title compound (55% total), both as solids. For the cis- isomer: IH NMR 1.20-1.40 (m, 1 H), 1.50-1.62 (m, 1 H), 2.60-2.98 (m, 2 H), 3.86 (dt, ,l H), 4.24 (d, 1 H), 4.34 (dd, 1 H), 4.45 (d, 1 H), 6.40 (br s, 1 H), 7.24 (m, 2 H), 7.40 (m, 3 H), 7.50 (s, 2 H), 7.70 (s, 1 H). EXAMPLE 12 3-Phenyl-2-(2-(3.5-bis(trifluoromethyl)pheny ethylVmoφholine A solution of 95 mg (0.23 mmol) of 2-(2-(3,5- bis(trifluoromethyl)phenyl)ethenyl)-3-phenyl-5-oxo-moφholine (Example 11) in 10 mL of 1:1 v/v ethanol/ ethyl acetate was treated with 10 mg of palladium hydroxide and the resulting mixture was stirred under an atmosphere of hydrogen for 2 h. The catalyst was filtered and the filtrate was concentrated m vacuo. The crude product was used directly without further purification. A solution of 65 mg of the crude moφholinone was dissolved in 10 mL of tetrahydrofuran was treated with 0.84 mL of 1 M borane'tetrahydrofuran complex solution in tetrahydrofuran and the resulting solution was heated at reflux for 16 h. The reaction was quenched by adding 10 mL of methanol and 70 mg of potassium carbonate and heating the resulting mixture at reflux for 3 h. All volatiles were removed in vacuo and the residue was partitioned between 20 mL of ethyl acetate and 10 mL of saturated ammonium chloride solution. The organic layer was separated, dried over sodium carbonate, and concentrated in vacuo. The residue was dissolved in saturated HCl in methanol and concentrated in vacuo. The residue was triturated with ether; the resulting solid was filtered and dried to afford 32 mg (46%) of the title compound • HCl, mp 114-116°C: lH NMR 1.42 (m, 1 H), 1.66-1.84 (m, 1 H). 170-2.94 (m, 2 H), 3.00 (m, 1 H), 3.30-3.46 (m, 1 H), 3.80-3.94 (m, 2 H), 4.10 (m, 1 H), 4.20 (d, 1 H), 7.40 (m, 3 H), 7.64 (m, 5 H); CI-MS 402(M+1)+. EXAMPLE 13 N-Benzyl-(SVphenylglycine A solution of 1.51 g (10.0 mmol) of (S)-phenylglycine in 5 mL of 2 N aqueous sodium hydroxide solution was treated with 1.0 mL (10.0 mmol) of benzaldehyde and stirred at room temperature for 20 minutes. The solution was diluted with 5 mL of methanol, cooled to 0°C, and carefully treated with 200 mg (5.3 mmol) of sodium borohydride. The cooling bath was removed and the reaction mixture was stirred at room temperature for 1.5 hours. The reaction was diluted with 20 mL of water and extracted with 2x25 mL of methylene chloride. The aqueous layer was acidified with concentrated hydrochloric acid to pH 6 and the solid that precipitated was filtered, washed with 50 mL of water, 50 mL of 1 : 1 v/v methanol/ethyl ether and 50 mL of ether, and dried to afford 1.83 g (76%) of product, mp 230-232°C. Analysis Calcd for C15H15NO2: C, 74.66; H, 6.27; N, 5.81. Found: -C, 74.17; H, 6.19; N, 5.86. EXAMPLE 14 3-(S)-Phenyl-4-benzyl-2-moφholinone A mixture of 4.00 g (16.6 mmol) of N-benzyl-(S)- phenylglycine (from Example 13), 5.00 g (36.0 mmol) of potassium carbonate, 10.0 mL of 1,2-dibromoethane and 25 mL of N,N- dimethylformamide was stirred at 100°C for 20 hours. The mixture was cooled and partitioned between 200 mL of ethyl ether and 100 mL of water. The layers were separated and the organic layer was washed with 3x50 mL of water, dried over magnesium sulfate and concentrated in vacuo. The residue was purified by flash chromatography on 125 g of silica gel eluting with 9: 1 v/v, then 4: 1 v/v hexanes/ethyl ether to afford 2.41 g (54%) of the product as a solid, mp 98-100°C. Mass Spectrum (FAB): m/Z 268 (M+H, 100%). lH NMR (CDCI3, 200 MHz, ppm): δ 2.54-2.68 (m, IH), 2.96 (dt, J= 12.8, 2.8, IH), 3.14 (d, J= 13.3, IH), 3.75 (d, J= 13.3, IH), 4.23 (s, IH), 4.29-4.37 (m, IH), 4.53 (dt, J= 3.2, 11.0), 7.20-7.56 (m, 10H). Analysis Calcd for C17H17NO2: C, 76.38; H, 6.41; N, 5.24. Found: C, 76.06; H, 6.40; N, 5.78. EXAMPLE 15 2-(S 3.5-Bis(trifluoromethyl benzyloxy)-3-(S)-phenylmoφholine Step A: 3,5-Bis(trifluoromethyl)benzyl alcohol, trifluoromethane- sulfonate ester A solution of 1.00 g (4.1- mmole) of 3,5-bis(trifluoro- methyl)benzyl alcohol and 1.05 g (5.12 mmole) of 2,6-di-t-butyl-4- methylpyridine in 45 mL of dry carbon tetrachloride under a nitrogen atmosphere was treated with 0.74 mL (4.38 mmole) of trifluoro- methanesulfonic anhydride at room temperature. A white precipitate formed shortly after the addition of the anhydride. After 90 min, the slurry was filtered under nitrogen with a Schlenk filter, and the filtrate was concentrated in vacuo. The residue, which was a two-phase oil, was dissolved under nitrogen in 10 mL of dry toluene. The resulting clear solution was used immediately in Step B below. Step B: 4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)benz-yloxy)-3-(S)- phenylmorpholine A solution of 0.500 g (1.87 mmole) of N-benzyl-3-(S)- phenylmoφholin-2-one (from Example 14) in 10 mL of dry THF was cooled to -75°C under nitrogen and was treated dropwise with 2.06 mL (2.06 mmole) of a 1M solution of lithium tri(sec-butyl)-borohydride (L-Selectride®) in THF. After stirring the solution at -75°C for 30 min, a solution of 3,5-bis(trifluoromethyl)benzyl alcohol, trifluoro- methanesulfonate ester in toluene was added by cannula so that the internal temperature was maintained below -60°C. The resulting solution was stirred at -75°C for 1 hr and then between -38°C and -50°C for 2 hr. The solution was then poured into a mixture of 25 mL of ethyl acetate and 20 mL of saturated aqueous sodium bicarbonate, and the layers were separated. The aqueous phase was extracted with 2x30 mL of ethyl acetate, the combined organic layers were dried over sodium sulfate, the mixture was filtered and the filtrate concentrated in vacuo. The residue was purified by flash chromatography on 130 g of silica eluting with 2 L of 100:5 hexanes:ethyl acetate to give 0.68 g (73%) of an oil, which by lH NMR is a 20: 1 mixture of cis:trans moφholines. lH NMR (CDC13, 400 MHz, ppm): δ major (cis) isomer: 2.37 (td, J= 12, 3.6, IH), 2.86 (app t, J= 13, 2H), 3.57 (d, J= 2.6, IH), 3.63 (dq, J= 11.3, 1,6, IH), 3.89 (d, J= 13.3, IH), 4.12 (td, J= 11.6, 2.4, IH), 4 ; 40 (d, J= 13.6, IH), 4.69 (d, J= 2.9, IH); 4.77 (d, J= 13.6), 7.2-7.4 (m, 8H), 7.43 (s, 2H), 7.55 (br d, 2H), 7.69 (s, IH). Step C: 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl- morpholine A mixture of 0.68 g (1.37 mmole) of 4-benzyl-2-(S)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(S)-phenylmoφholine and 280 mg of 10% Pd C in 36 mL of 97:3 ethanokwater was stirred under one atmosphere of hydrogen for 15 hr. The mixture was filtered through Celite, the filter cake was washed generously with ethanol, and the filtrated was concentrated in vacuo. The residue was purified by flash chromatography on 68 g of silica eluting with 1L of 33:67 hexanes: diethyl ether, then 1L of 25:75 hexanes: diethyl ether to give 0.443 g (80%) of an oil, which by lH NMR was pure cis moφholine. lH NMR (CDCI3, 400 MHz, ppm): δ 1.8 (br s, IH), 3.10 (dd, J= 12.5, 2.9, IH), 3.24 (td, J= 12.2, 3.6, IH), 3.62 (dd, J= 11.3, 2.5, IH), 4.04 (td, J= 11.7, 3, IH), 4.11 (d, J= 2.4, IH), 4.49 (d, J= 13.5, IH), 4.74 (d, J= 2.5, IH), 4.80 (d, J= 13.3, IH), 7.25-7.40 (m, 5H), 7.40 (s, 2H), 7.68 (s, IH). Analysis Calcd for C19H17F6NO2: C, 56.30; H, 4.23; N, 3.46; F, 28.12. Found: C, 56.20; H, 4.29; N, 3.34; F, 27:94. EXAMPLE 16 2(R1-(3.5-Bis(trifluoromethyl)benzyloxyV3(R -phenyl-moφholine The title compound was prepared from (R)-phenylglycine employing the procedures of Examples 13, 14 and 15. EXAMPLE 17 4-(3-(l,2,4-Triazolo)methyl)-2-(S)-(3,5-bis(trifluoro-methyl)- benzyloxy)-3-(S)-phenylmorpholine Step A: N-Formyl-2-chloroacetamidrazone A solution of 5 g (66.2 mmole) of chloroacetonitrile in 30 mL of dry methanol was cooled to 0°C under nitrogen and was treated with O.lg (1.8 mmole) of sodium methoxide. The mixture was allowed to warm to room temperature and was stirred for 30 min, and 0.106 mL (1.8 mmole) of acetic acid was added. To the resulting mixture was then added 3.9 g (64.9 mmole) of formic hydrazide, and the material was stirred for 30 min. The reaction mixture was concentrated in vacuo to a solid, and was used as such in Step B below. Step B: 4-(3-(l,2,4-Triazolo)methyl)-2-(S)-(3,5-bis-(trifluoro- methyl benzyloxy)-3-(SVphenyl-moφholine A solution of 0.295g (0.73 mmole) of 2-(S)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(S)-phenylmoφholine (from Example 15) in 10 mL of dry DMF was treated with 0.302g (2.18 mmole) of anhydrous potassium carbonate and then 0.168g (1.24 mmole) of N- formyl-2-chloroacetamidrazone (from Example 17, Step A) and the suspension was stirred at 60°C for 4 hr. The mixture was then heated to 120°C for 4.5 hr. After cooling, the reaction was diluted with 80 mL of ethyl acetate and the organic layer was washed with 3x20 mL of water. The organic layer was dried over magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by flash chromatography on 67 g of silica eluting with 1.5 L of 100:2 methylene chloride: methanol to give 0.22 g of a yellow solid, which was recrystallized from hexanes/methylene chloride to give 0.213g (60%) of a white crystalline solid, mp 134-135°C. Mass Spectrum (FAB): m/Z 487 (M+H, 100%), 259 (35%), 243 (65%), 227 (40%), 174 (25%). IH NMR (CDC13, 400 MHz, ppm): δ 2.67 (td, J= 11.9, 3.4, IH), 2.90 (br d, J= 11.7, IH), 3.43 (d, J= 15.2, IH), 3.66 (app dd, J= 13, 1.9, 2H), 3.88 (d, J= 15.1, IH), 4.17 (td, J= 11.7, 2.3, IH), 4.42 (d, J= 13.5, IH), 4.69 (d, J= 2.6, IH), 4.77 (d, J= 13.5, IH), 7.30-7.50 (m, 7H), 7.70 (s, IH), 7.94 (s, IH). EXAMPLE 18 4-(3-(5-Oxo-lH,4H-l,2,4-triazolo)methyl)-2-(S)-(3,5-bis(trifluoro- methyl) benzyloxy -3-(S -phenylmoφholine Step A: N-Methylcarboxy-2-chloroacetamidrazone A solution of 5.0 g (66.2 mmol) of chloroacetonitrile in 35 mL of dry methanol was cooled to 0°C and was treated with 0.105 g (1.9 mmol) of sodium methoxide. The ice-bath was removed and the mixture was alowed to stir at room temperature for 30 minutes. To the reaction was then added 0.110 mL (1.9 mmol) of acetic acid and then 5.8 g (64.9 mmol) of methyl hydrazinecarboxylate. After stirring 30 minutes at room temperature, the suspension was concentrated in vacuo. and placed on the high-vac line overnight, to give 10.5 g (98%) of a yellow powder, which was employed in Step C belo . lH NMR (CD3OD, 400 MHz, ppm): δ 3.71 (s, 3H), 4.06 (s, 2H). Step B: 4-(2-(N-Meti_ιylcarboxy-acetamidrazono)-2-(S)-(3,5- bis(trifluoromethyl benzyloxyV3-(SVphenylmoφholine A solution of 2.30 g (5.7 mmol) of 2-(S)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(S)-phenylmoφholine (from Example 15), 1.13 g (6.8 mmol) of N-methylcarboxy-2-chloroacetamidrazone (from Step A), and 1.50 mL (8.6 mmol) N,N-diisopropylethylamine in 25 mL of acetonitrile was stirred at room temperature for 20 hours. The product, which had preciptated, was filtered, washed with 5 mL of ice cold acetonitrile and dried to give 1.83 g of a white solid. The filtrate was concentrated in vacuo and the residue was partitioned between 50 mL of methylene chloride and 20 mL of water. The layers were separated and the organic layer was dried over magnesium sulfate. The aqueous layer was extracted with 50 mL of methylene chloride; the extract was dried, combined with the original organic layer, and the combined organics were concentrated in vacuo. The residue was purified by flash chromatography on 30 g of silica gel eluting with 50:1:0.1 v/v/v methylene chloride/methanol/ammonium hydroxide to affojrd an additional 1.09 g of product (96% total). Mass Spectrum (FAB): m/Z 535 (M+H, 100%), 462 (16%), 291 (30%), 226 (35%), 173 (25%). lH NMR (CDC13, 400 MHz, ppm): δ 2.53 (dt, J= 3.5, 12.2, IH), 2.59 (d, J= 14.6, IH), 2.94 (d, J= 11.8, IH), 3.37 (d, J= 14.6, IH), 3.58 (d, J= 2.8), IH), 3.62-3.72 (m, IH), 3.75 (s, 3H), 4.16 (dt, J= 2.2, 11.8, IH), 4.44 (d, J= 13.2, IH), 4.70 (d, J= 2.8, IH), 4.79 (d, J= 13.2), 5.55 (br s, 2H), 7.30-7.46 (m, 7H), 7.72 (s, IH). Step C: 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(3-(5-oxo- lH.4H-1.2.4-triazolo methylV3-(SVphenylmoφholine A solution of 2.89 g (5.4 mmol) of 4-(2-(N-methyl- carboxyacetamidrazono)-2-(S)-(3,5-bis(trifluoromethyl) benzyloxy)-3- (S)-phenylmoφholine (from Step B) in 36 mL of xylenes was heated at reflux for 1.5 hours. The solution was cooled and concentrated m vacuo. The residue was taken up in 50 mL of 3:1 v/v hexanes/ethyl acetate which caused crystallization of the product. The product was filtered and dried to afford 1.85 g of a solid. Recrystallization of the solid from 30 mL of 4:1 v/v hexanes/ethyl acetate afforded 1.19 g of pure product as a white solid, mp= 156-157°C. All of the crystallization liquors were combined and concentrated in vacuo. The residue was purified by flash chromatography on 30 g of silica gel eluting with 50:1:0.1 v/v/v methylene chloride/methanol/ammonium hydroxide to afford an additional 0.69 g of a solid. Three recrystallizations from 20 mL of 4: 1 v/v hexanes/ethyl acetate afforded an additional 0.39 g of pure product as a white solid (58% total). Mass Spectrum (FAB): m/Z 503 (M+H), 259 (55%), 226 (40%), 160 (30%). lH NMR (CDC13, 400 MHz, ppm): δ 2.57 (app t, J= 9.6, IH), 2.87-2.97 (m, 2H), 3.58-3.71 (m, 3H), 4.18 (app t, J= 10.4, IH), 4.46 (d, J= 13.6), 4.68 (d, J= 2.8, IH), 4.85 (d, J= 13.6, IH), 7.30-7.45 (m, 7H), 7.64 (s, IH), 10.40 (br s, IH), 10.73 (br s, IH). EXAMPLE 19 N-(2-(R)-Hydroxypropyl)-phenylglycinal, 3,5-bis(tri-fluoromethyl)- benzyl acetal A mixture of 1.00 g (1.5 mmol) of (+/-)-a- bromo- phenylacetaldehyde, 3,5-bis(trifluoromethyl)-benzyl acetal (from Example 12), 1.25 mL of (R)-l-amino-2-proρanol, 225 mg (1.5 mmol) of sodium iodide, and 3.75 mL of isopropanol was heated at reflux for 20 h. The solution was cooled and concentrated to -25% the original volume in vacuo. The concentrated solution was partitioned between 50 mL of ether and 20 mL of 2 N aqueous sodium hydroxide solution and the layers were separated. The organic layer was washed with 20 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated in vacuo. Flash chromatography on 50 g of silica gel using 65:35 v/v ether/hexane as the eluant afforded 948 mg (95%) of the product as a 1: 1 mixture of inseparable diastereomers. Mass Spectrum (FAB): m/Z 664 (M+H, 25%), 420 (20%), 226 (100%). EXAMPLE 20 N-(2-(S)-Hydroxypropyl)-phenylglycinal, 3,5-bis(tri-fluoromethyl)- benzyl acetal Substitution of (S)-l-amino-2-propanol for (R)-l-amino-2- propanol in an experiment identical to the preceding example afforded 940 mg (95%) of the product as a 1:1 mixture of diastereomers. EXAMPLE 21 N-(2-(R)-Hydroxyρropyl)-N-(prop-2-enyl)-(R)-phenyl-glycinal, 3,5- bis(trifluoromethyl)benzyl acetal and N-(2-(R)-Hydroxypropyl)-N- (prop-2-enyl)-(S)-phenyl-glycinal, 3,5-bis(trifluoromethyl)benzyl acetal A mixture of 933 mg (1.40 mmol) of N-(2-(R)- hydroxy- propyl)-phenylglycinal, 3,5-bis(trifluoromethyl)-benzyl acetal (from Example 19), 1 mL of allyl bromide, 600 mg (4.3 mmol) of potassium carbonate, and 5 mL of ethanol was stirred at 60°C for 20 hours. The mixture was cooled, partitioned between 100 mL of ethyl ether and 25 mL of water and the layers were separated. Flash chromatography on 50 g of silica gel using 20:1 v/v ether/hexanes as the eluant afforded 380 mg of the (R,R)-amino alcohol (Rf = 0.72 with 3:2 v/v ether/hexanes as the eluant), 220 mg of the (R,S)-amino alcohol (Rf = 0.62 with 3:2 v/v ether/hexanes as the eluant), and 285 mg of a mixture of the disastereomeric amino alcohols. For the (R.RVamino alcohol: Mass Spectrum (FAB): m/Z 704(M+H). IR (neat) 3476, 2932, 1624, 1454, 1361, 1278, 1175, 1132, 760, 704, 682. lH NMR (CDC13, 400 MHz, ppm) 1.12 (d, 3 H, J = 6.4), 2.19 and 2.62 (dAB q, 2 H, J AB = 13.0, J 2.19 = 2.3, J 2.62 = 10.4), 2.97 (dd, 1 H, J = 14.0, 8.8), 3.25 - 3.30 (m, 1 H), 3.76 (s, 1 H), 3.77 - 3.85 (m, 1 H), 4.21 (d, 1 H, J = 8.8), 4.49 and 4.55 (AB q, 2 H, J = 12.4), 4.86 and 4.92 (AB q, 2 H, J = 12.4), 5.27 - 5.33 (m, 2 H), 5.39 (d, 1 H, J = 8.8), 5.79 - 5.89 (m, 1 H), 7.21 - 7.26 (m, 4 H), 7.35 - 7.40 (m, 3 H), 7.67 (s, 1 H), 7.81 (s, 1 H), 7.85 (s, 2 H). Analysis Calcd for C32H29F12NO3: C, 54.63; H, 4.15; N, 1.99; F, 32.41. Found: C, 54.72; H, 3.94; N, 1.95; F, 32.17. For the (R.SVamino alcohol: Mass Spectrum (FAB): m/Z 704(M+1). IR (neat) 3451, 2931, 1624, 1454, 1362, 1277, 704, 683. lH NMR (CDCI3, 400 MHz, ppm) 1.09 (d, 3 H, J = 6.0), 2.48 and 2.71 (dAB q, 2 H, J AB = 13.2, J 2.48 = 9.6, J 2.62 = 3.6), 3.05 (dd, 1 H, J = 14.4, 6.8), 3.34 - 3.39 (m, 1 H), 3.35 (s, 1 H), 3.76 - 3.81 (m, 1 H), 4.21 (d, 1 H, J = 8.4), 4.50 and 4.54 (AB q, 2 H, J = 12.8), 4.86 and 4.96 (AB q, 2 H, J = 12.4), 5.10 - 5.17 (m, 2 H), 5.39 (d, 1 H, J = 8.4), 5.68 - 5.78 (m, 1 H), 7.23 - 7.32 (m, 4 H), 7.34 - 7.39 (m, 3 H), 7.69 (s, 1 H), 7.83 (s, 1 H), 7.86 (s, 2 H). Analysis Calcd for C32H29F12NO3: C, 54.63; H, 4.15; N, 1.99; F, 32.41. Found: C, 54.80; H, 4.16; N, 1.90; F, 32.36. EXAMPLE 22 N-(2-(S)-Hydroxypropyl)-N-(prop-2-enyl)-(S)-phenyl-glycinal, 3,5-bis(trifluoromethyl)benzyl acetal and N-(2-(S)-Hydroxypropyl)-N- (prop-2-enyl)-(R)-phenyl-glycinal, 3,5-bis(trifluoromethyl)benzyl acetal Substitution of 880 mg (1.33 mmol) of N-(2-(S)-hydroxy- propyl)-phenylglycinal, 3,5-bis(trifluoro-methyl)benzyl acetal (Example 20) for the N-(2-(R)-hydroxypropyl)-phenylglycinal, 3,5-bis(trifluoro- methyl)benzyl acetal in the procedures of the preceding example afforded 281 mg of the (S,S)-amino alcohol (Rf = 0.72 with 3:2 v/v ether/hexanes as the eluant), 367 mg of the (S,R)-amino alcohol (Rf = 0.62 with 3:2 v/v ether/hexanes as the eluant), and 197 mg of a mixture of the disastereomeric amino alcohols. EXAMPLE 23 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(R)-methyl moφholine and 2-(S)-(3,5-Bis-(trifluoromethyl)benzyloxy)-3-(R)- phenyl-6-(R -methyl moφholine Step A: 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-ρhenyl-4- (2-ρropenyl)-6-(R)-methyl moφholine and 2-(S)-(3,5- bis(trifluoro-methyl)-benzyloxy)-3-(R)-phenyl-4-(2-pro- penyl -6-(RVmethyl moφholine A solution of 355 mg (0.50 mmol) of N-(2-(R)-hydroxy- propyl)-N-(2-propenyl)-(R)-phenylglycinal, 3 ,5-bis(trifluoromethyl)- benzyl acetal (from Example 21) and 285 mg (1.5 mmol) of p- toluensulfonic acid monohydrate in 5 mL of toluene was heated at reflux for 40 min. The solution was cooled and partitioned between 40 mL of ether and 15 mL of saturated aqueous sodium bicarbonate solution. The layers were separated; the organic layer was washed with 10 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate, and concentrated in vacuo. Flash chromatography on 10 g of silica gel using 19:1 v/v hexanes/ether as the eluant afforded 122 mg of (2R,3R,6R) product (Rf = 0.53 with 4:1 v/v hexanes/ether as the eluant) and 62 mg of the (2S,3R,6R) product (Rf = 0.23 with 4:1 v/v hexanes/ether as the eluant). For the (2R.3R.6R product: Mass Spectrum (FAB): m/Z 460 (M+H, 65%) lH NMR (CDC13, 400 MHz, ppm) 1.35 (d. 3 H, J = 6.4), 2.53 and 2.63 (dAB q, 2 H, J AB = 12.0, J 2.53 = 3.2, J 2.63 = 6.8), 2.83 - 2.96 (m, 2 H), 3.60 (d, 1 H, J = 4.0), 4.27 - 4.32 (m, 1 H), 4.57 and 4.84 (AB q, 2 H, J = 13.2), 4.87 (d, 1 H, J = 4.0), 5.08 - 5.13 (m, 2 H), 5.76 - 5.86 (m, 1 H), 7.31 - 7.37 (m, 3 H), 7.50 - 7.52 (m, 2 H), 7.58 (s, 2 H), 7.71 (s, 1 H). For the (2S.3R.6R product: Mass Spectrum (FAB): m/Z 460 (M+H, 65%) lH NMR (CDC13, 400 MHz, ppm) 1.37 (d. 3 H, J = 6.8), 2.48 - 2.50 (m, 2 H), 2.74 and 3.01 (dtAB q, 2 H, J = 6.4, 1.2, 12.4) 3.84 (d, 1 H, J = 3.6), 3.92 - 3.99 (m, 1 H), 4.70 and 4.93 (AB q, 2 H, J = 13.6), 4.97 (d, 1 H, J = 3.6), 5.08 - 5.14 (m, 2 H), 5.74 - 5.84 (m, 1 H), 7.28 - 7.36 (m, 3 H), 7.43 - 7.46 (m, 2 H), 7.64 (s, 2 H), 7.75 (s, 1 H). Step B: 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6- (R)-methyl moφholine A solution of 115 mg (0.25 mmol) of the 2-(R)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-4-(2-propenyl)-6-(R)- methyl moφholine (from Example 23, Step A) and 230 mg (0.25 mmol) of tris(triphenylphosphine)rhodium chloride in 15 mL of 4: 1 v/v acetonitrile/water was heated at reflux for 30 min. The reaction was cooled and partitioned between 50 mL of ethyl acetate and 15 mL of water. The layers were separated and the organic layer was dried over magnesium sulfate. The aqueous layer was extracted with 2 x 25 mL of ethyl acetate; the extracts were dried and combined with the original organic layer. The combined organics were concentrated in vacuo. The residue was filtered through a pad of silica gel (~ 20 g) using 2: 1 v/v ether/hexanes as the solvent. The filtrate was concentrated; flash chromatography on 5 g of silica gel using 17:3 v/v hexanes/ether as the eluant afforded 67 mg (64%) of 2-(R)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(R)-methyl moφholine as an oil. Mass Spectrum (FAB): m/Z 420 (M+H, 90%) lH NMR (CDCI3, 400 MHz, ppm) 1.21 (d, 3 H, J = 6.4), 2.02 (br s, 1 H), 2.67 and 2.77 (dAB q, 2 H, J AB = 13.2, J 2.67 = 8.8, J 2.77 = 3.2), 3.89 (d, 1 H, J = 2.4), 4.07 - 4.15 (m, 1 H), 4.68 and 4.90 (AB q, 2 H, J = 12.8), 5.03 (d, 1 H, J = 2.4), 7.28 - 7.38 (m, 3 H), 7.51 - 7.53 (m, 2 H), 7.77 (s, 2 H), 7.79 (s, 1 H). Step C: 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6- (RVmethyl morpholine A similar reaction was carried out using 55 mg (0.12 mmol) of 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-4-(2- propenyl)-6-(R)-methyl moφholine (from Example 23, Step A) and 111 mg (0.12 mmol) of tris(triphenylphosphine)rhodium chloride in 12 mL of 4: 1 v/v acetonitrile/water. Flash chromatography on 4 g of silica gel using 50: 1 v/v methylene chloride/acetonitrile as the eluant afforded 14 mg (28%) of 2-(S)-(3,5-bis(trifluoromethyl)-benzyloxy)-3- (R)-phenyl-6-(R)-methyl moφholine as an oil. Mass Spectrum (FAB): m/Z 420 (M+H, 90%) lH NMR (CDC13, 400 MHz, ppm) 1.39 (d, 3 H, J = 6.8), 1.92 (br s, 1 H), 2.84 and 2.95 (dAB q, 2 H, J AB = 12.8, J 2.84 = 6.4, J 2.95 = 3.6), 3.93 - 4.00 (m, 1 H), 4.07 (d, 1 H, J = 2.8), 4.68 and 4.95 (AB q, 2 H, J = 13.2), 4.93 (d, 1 H, J = 2.8), 7.28 - 7.37 (m, 3 H), 7.48 - 7.52 (m, 2 H), 7.55 (s, 2 H), 7.72 (s, 1 H). EXAMPLE 24 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-ρhenyl-6-(S)-methyl moφholine and 2-(R)-(3,5-Bis-(trifluoromethyl)benzyloxy)-3-(S)- phenyl-6-(S)-methyl morpholine Substitution of 350 mg of N-(2-(S)-hydroxy-propyl)-N-(2- propenyl)-(S)-phenylglycinal, 3 ,5-bis-(trifluoromethyl)benzyl acetal (from Example 22) for N-(2-(R)-hydroxypropyl)-N-(2-propenyl)-(R)- phenyl-glycinal, 3,5-bis(trifluoromethyl)benzyl acetal in an experiment similar to the preceding example afforded 50 mg of 2-(S)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(S)-methyl moφholine and 14 mg of 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6- (S)-methyl moφholine. EXAMPLE 25 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(R)-methyl moφholine and 2-(S)-(3,5-Bis-(lxifluoromethyl)benzyloxy)-3-(S)- phenyl-6-(R)-methyl morpholine Step A: 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-ρhenyl-4- (2-propenyl)-6-(R)-methyl moφholine and 2-(S)-(3,5- bis(trifluoro-methyl)-benzyloxy)-3-(S)-ρhenyl-4-(2-pro- penyl)-6-(RVmethyl morpholine The title compounds were prepared in a manner similar to Example 23, Step A. Cyclization of 300 mg (0.43 mmol) N-(2-(R)- hydroxypropyl)-N-(prop-2-enyl)-(S)-phenylglycinal, 3,5-bis(trifluoro- methyl)benzyl acetal (from Example 23) was effected using 246 mg (1.29 mmol) of p-toluenesulfonic acid monohydrate and 5 mL of toluene. Rash chromatography on 8 g of silica gel using 20:1 v/v hexanes/ether as the eluant afforded 149 mg (75%) of the products as inseparable diastereomers. Mass Spectrum (FAB): m/Z 460 (M+H, 65%). Step B: 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-6- (R)-methyl moφholine and 2-(S)-(3,5-Bis(trifluoro- methyl)benzyloxyV3-(SVphenyl-6-(R)-methyl moφholine A solution of 150 mg (0.33 mmol) of 2-(R)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-4-(2-propenyl)-6-(R)- methyl moφholine and 2-(S)-(3,5-bis-(trifluoromethyl)-benzyloxy)-3- (S)-phenyl-4-(2-propenyl)-6-(R)-methyl moφholine (from Example 25, Step A) and 318 mg (0.32 mmol) of tris(triphenyl-phosphine)-rhodium chloride in 20 mL of 4: 1 v/v acetonitrile/water was heated at reflux for 1 h. Flash chromatography on 5 g of silica gel using 9:1 v/v hexanes/ether as the eluant afforded 35 mg of the products as a mixture and 26 mg of 2-(R)-(3,5-bis-(trifluoromethyl)benzyloxy)-3-(S)-phenyl- 6-(R)-methyl moφholine (Rf = 0.22 with 3:2 v/v hexanes/ether as the eluant). Chromatography of the mixture on 5 g of silica gel using 20:1 v/v afforded 14 mg of 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)- phenyl-6-(R)-methyl moφholine (Rf = 0.14 with 3:2 v/v hexanes/ether as the eluant) and 17 mg of 2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)- 3-(S)-phenyl-6-(R)-methyl moφholine (41% total yield). For the (2R.3S.6R) product: Mass Spectrum (FAB): m/Z 420 (M+H, 90%) lH NMR (CDC13, 400 Mhz. ppm) 1.30 (d, 3 H, J = 6.4), 1.74 (br s, 1 H), 2.73 and 2.98 (dAB q, 2 H, J AB = H*6, J 2.73 = 10.0, J 2.98 = 2.4), 3.65 (d, 1 H, J = 7.2), 3.89 - 3.94 (m, 1 H), 4.45 (d, 1 H, J = 7.2), 4.53 and 4.90 (AB q, 2 H, J = 13.2), 7.28 - 7.38 (m, 3 H), 7.41 - 7.43 (m, 2 H), 7.45 (s, 2 H), 7.70 (s, 1 H). For the (2S.3S.6R product: Mass Spectrum (FAB): m Z 420 (M+H, 90%) lH NMR (CDCI3, 400 Mhz. ppm) 1.20 (d, 3 H, J = 6.4), 2.04 (br s, 1 H), 2.84 and 3.15 (dAB q, 2 H, J AB = 12.8, J 2.84 = 10.8, J 3.15 = 2.8), 4.08 (d, IH, J = 2.8), 4.08 - 4.15 (m, 1 H), 4.53 and 4.80 (AB q, 2 H, J = 13.2), 4.79 (d, 1 H, J = 2.8), 7.28 - 7.38 (m, 5 H), 7.43 (s, 2 H), 7.70 (s, 1 H). EXAMPLE 26 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(S)-methyl moφholine and 2-(R)-(3,5-Bis-(trifluoromethyl)benzyloxy)-3-(R)- phenyl-6-(S)-methyl moφholine Substitution of 250 mg of N-(2-(S)- hydroxy-ρropyl)-N-(2- propenyl)-(S)-phenylglycinal, 3,5-bis-(trifluoromethyl)benzyl acetal (from Example 22) for N-(2-(R)-hydroxypropyl)-N-(2-propenyl)-(R)- phenyl-glycinal, 3,5-bis(trifluoromethyl)benzyl acetal in an experiment similar to the preceding example afforded 42 mg of 2-(S)-(3,5-bis- (trifluoromethyl)benzyloxy)-3-(R)-phenyl-6-(S)-methyl moφholine and 17 mg of 2-(S)-(3,5-bis(trifluoro- methyl)benzyloxy)-3-(R)-phenyl-6- (S)-methyl moφholine. EXAMPLE 27 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-methyl moφholine, 2-(S)-(3,5-Bis-(tri-fluoromethyl)benzyloxy)-3-(S)-phenyl- 5-(R)-methyl moφholine, 2-(R or S)-(3,5-Bis(trifluoromethyl)- benzyloxy)-3-(R)-phenyl-5-(R)-methylmoφholine, and 2-(S or R)-(3,5- Bis(trifluoromethy benzyloxyV3-(RVphenyl-5-(RVmethylmoφholine Execution of the sequence described in Example 19 substituting (R)-2-amino-l-propanol for (R)-l-amino-2-propanol provided a mixture of 55 mg of high Rf material and 56 mg of low Rf material. The high Rf material was processed according to Example 23, Step A above to provide 10 mg of high Rf material (2-(R)-(3,5- Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-methyl moφholine and 7 mg of low Rf material (2-(S)-(3,5-Bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-5-(R)-methyl moφholine. The low Rf material (after, being combined with an additional 30 mg of material) was processed according to Example 23, Step A to provide 24 mg of high Rf material (2-(R or S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3- (R)-phenyl-5-(R)-methyl-moφholine and 18 mg of low Rf material (2- (S or R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(R)- methylmoφholine. 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-methyl morpholine Mass Spectrum (FAB): m/Z 420 (M+H, 100%), 227 (50%), 192 (75%), 176 (65%). NMR (CDC13, 400 MHz, ppm): δ 0.98 (d, 3H, J= 6 3 Hz), 3.16-3.20 (m, IH), 3.43-3.47 (m, IH), 3.79 (d, IH, J= 7.5 Hz), 3.91 (dd, IH, J= 3.2 &11.5 Hz), 4.51 (d, 2H, J= 13.4 Hz), 4.85 (d, IH, J= 13.2 Hz), 7.29- 7.45 (m, 7H), 7.67 (s, IH). 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-methyl morpholine Mass Spectrum (FAB): m Z 420 (M+H, 48%), 227 (35%), 192 (39%), 176 (100%). NMR (CDC13, 400 MHz, ppm): δ 1.10 (d, 3H, J= 6.4 Hz), 3.23-3.26 (m, IH), 3.56-3.61 (m, 2H), 4.17 (d, IH, J= 2.3 Hz), 4.51 (d, IH, J= 13.7 Hz), 4.71 (d, IH, J= 2.4 Hz), 4.78 (d, IH, J= 13.5 Hz), 7.28-7.39 (m, 7H), 7.68 (s, IH). 2-(R or S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(R)- methyl moφholine Mass Spectrum (FAB): m/Z 281 (35%), 221 (55%), 207 (45%), 192 (40%), 147 (100%). NMR (CDCI3, 400 MHz, ppm): δ 1.13 (d, 3H, J= 6.6 Hz), 3.10-3.14 (m, IH), 3.66 (dd, IH, J= 6.6 & 11.4 Hz), 3.76 (dd, IH, J= 3.5 & 11.2 Hz), 4.04 (d, IH, J= 4.0 Hz), 4.61 (d, IH, J= 13.2 Hz), 4.74 (d, IH, J= 3.9 Hz), 4.89 (d, IH, 13.2 Hz), 7.26-7.35 (m, 3H), 7.47-7.49 (m, 2H), 7.64 (s, IH), 7.74 (s, IH). 2-(R or S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(R)- methyl moφholine NMR (CDCI3, 400 MHz, ppm): δ 1.36 (d, 3H, J= 6.7 Hz), 3.27-3.31 (m, IH), 3.39 (dd, IH, J= 2.2 & 11.3 Hz), 4.16 (dd, IH, J= 3.2 & 11.0 Hz), 4.37 (d, IH, J= 2.3 Hz), 4.53 (d, IH, J= 13.5 Hz), 4.75 (d, IH, J= 2.5 Hz), 4.81 (d, IH, 13.6 Hz), 7.26-7.35 (m, 3H), 7.26-7.43 (m, 7H), 7.68 (s, IH). EXAMPLE 28 2-(R or S)-(3,5-Bis(trifluoromethyl)-benzyloxy)-3-(S)-phenyl-5-(S)- methylmoφholine, 2-(S or R)-(3,5-(-Bis-(trifluoromethyl)benzyloxy)- 3-(S)-phenyl-5-(S)-methyl-moφholine, and 2-(R)-(3,5-Bis(trifluoro- methy benzyl-oxy -3-(R)-phenyl-5-(SVmethylmoφholine Execution of the sequence described in Example 19 substituting (S)-2-amino-l-propanol for (R)-l-amino-2-propanol provided a mixture of 78 mg of high Rf material and 70 mg of low Rf material. The high Rf material was processed according to Example 23, Step A above to provide less than 1 mg of high Rf material (2-(R)-(3,5- Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(S)-methylmoφholine) and 9 mg of low Rf material (2-(S)-(3,5-Bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-5-(S)-methyl moφholine. The low Rf material was processed according to Example 23, Step A to provide 20 mg of high Rf material (2-(R or S)-(3,5-Bis(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-5-(S)-methylmoφholine and 14 mg of low Rf material (2-(S or R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl- 5-(S)-methylmoφholine. 2-(R or S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(S)- methyl moφholine Mass Spectrum (FAB): m/Z 420 (M+H, 60%), 227 (68%), 192 (56%), 176 (100%). NMR (CDCI3, 400 MHz, ppm): δ 1.12 (d, 3H, J= 6.6 Hz), 3.09-3.14 (m, IH), 3.65 (dd, IH, J= 6.6 & 11.0 Hz), 3.75 (dd, IH, J= 3.6 & 11.1 Hz), 4.04 (d, IH, J= 3.9 Hz), 4.61 (d, IH, J= 13.2 Hz), 4.73 (d, IH, J= # 3.9 Hz), 4.89 (d, IH, 13.2 Hz), 7.28-7.35 (m, 3H), 7.47 (d, 2H, 7.0 Hz)! 7.64 (s, IH), 7.74 (s, IH). 2-(S or R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(S)- methyl morpholine Mass Spectrum (FAB): m/Z 420 (M+H, 50%), 227 (45%), 192 (40%), 176 (100%). NMR (CDCI3, 400 MHz, ppm): δ 1.36 (d, 3H, J= 6.9 Hz), 3.27-3.29 (m, IH), 3.39 (dd, IH, J*- 2.2 & 11.1 Hz), 4.15 (dd, IH, J= 3.3 & 11.1 Hz), 4.37 (d, IH, J= 2.5 Hz), 4.52 (d, IH, J= 13.3 Hz), 4.75 (d, IH, J= 2.4 Hz), 4.81 (d, IH, 13.5 Hz), 7.28-7.43 (m, 7H), 7.68 (s, IH). 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)-methyl morpholine NMR (CDCI3, 400 MHz, ppm): δ 1.10 (d, 3H, J= 6.4 Hz), 3.22-3.25 (m, IH), 3.55-3.60 (m, 2H), 4.17 (d, IH, J= 2.3 Hz), 4.51 (d, IH, J= 13.5 Hz), 4.71 (d, IH, J= 2.4 Hz), 4.77 (d, IH, J= 13.6 Hz), 7.28-7.38 (m, 7H), 7.67 (s, IH). EXAMPLE 29 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)- phenylmoφholine, 2-(S)-(3,5-Bis(tri-fluoromethyl)benzyloxy)-3-(S)- phenyl-5-(R)-phenyl-moφholine, and 2-(R or S)-(3,5-Bis(trifluoro- methylVbenzyloxyV3-(RVphenyl-5-(RVphenylmoφholine Execution of the sequence described in Example 19 substituting (R)-2-amino-2-phenylethanol for (R)-l-amino-2-propanol provided a mixture of 62 mg of high Rf material and 52 mg of low Rf material. The high Rf material was processed according to Example 23, Step A above to provide 16 mg of high Rf material (2-(R)-(3,5- Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-phenylmoφholine and 4 mg of low Rf material (2-(S)-(3,5-Bis(trifluoromethyl)benzyl- oxy)-3-(S)-phenyl-5-(R)-phenylmoφholine . The low Rf material was processed according to Example 23, Step A to provide 4 mg of product (2-(R or S)-(3,5-Bis(trifluoromethyl)benzyl-oxy)-3-(R)-phenyl-5-(R)- phenylmoφholine. 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-phenyl- morpholine NMR (CDC13, 400 MHz, ppm): δ 3.62 (t, IH, J= 10.7 & 21.5 Hz), 3.93 (d, IH, J= 7.4 Hz), 3.99 (dd, IH, J= 3.1 & 11.2 Hz), 4.18 (dd, IH, J= 3.0 & 10.2 Hz), 4.46 (d, IH, J= 7.4 Hz), 4.53 (d, IH, J= 13.5 Hz), 4.89 (d, IH, J= 13.3 Hz), 7.28-7.55 (m, 12H), 7.69 (s, IH). 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(R)-phenyl- morpholine NMR (CDCI3, 400 MHz, ppm): δ 3.67 (dd, IH, J= 3.5 & 11.0 Hz), 3.89 (d, IH, J= 10.8 & 21.6 Hz), 4.25 (dd, IH, J= 3.3 & 11.0 Hz), 4.34 (d, IH, J= 2.2 Hz), 4.52 (d, IH, J= 13.8 Hz), 4.78-4.87 (m, 2H), 7.28- 7.51 (m, 12H), 7.69 (s, IH). 2-(R or S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(R)- phenylmorpholine NMR (CDC13, 400 MHz, ppm): δ 4.10-4.25 (m, 2H), 4.30-4.38 (m, IH), 4.48-4.54 (m, IH), 4.59-4.66 (m, IH), 4.86-5.00 (m, 2H), 7.25- 7.74 (m, 13H). EXAMPLE 30 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)- phenylmoφholine, 2-(R)-(3,5-Bis(tri-fluoromethyl)benzyloxy)-3-(R)- phenyl-5-(S)-phenyl-moφholine, 2-(R or S)-(3,5-Bis-(trifluoromethyl)- benzyloxy)-3-(S)-phenyl-5-(S)-phenyl-moφholine, and 2-(R or S)-(3,5- Bis(trifluoromethyDbenzyloxy)-3-(SVphenyl-5-(S)-phenylmoφholine Execution of the sequence described in Example 19 substituting (S)-2-amino-2-phenylethanol for (R)-l-amino-2-propanol provided a mixture of 75 mg of high Rf material and 64 mg of low Rf material. The high Rf material was processed according to Example 23, Step A above to provide 23 mg of high Rf material (2-(S)-(3,5- Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)-phenylmoφholine [L-740, 930]) and 7 mg of low Rf material (2-(R)-(3,5-Bis(trifluoro- methyl)benzyloxy)-3-(R)-phenyl-5-(S)-phenylmoφholine.The low Rf material was processed according to Example 23, Step A to provide 26 mg of higher Rf material (2-(R or S)-(3,5-Bis(trifluoromethyl)benzyl- oxy)-3-(S)-phenyl-5-(S)-phenylmoφholine and 6 mg of lower Rf material (2-(R or S)-(3,5-Bis(trifluoro-methyl)benzyloxy)-3-(S)- phenyl-5-(S)-phenylmoφholine. 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)-phenyl- morpholine NMR (CDCI3, 400 MHz, ppm): δ 3.60-3.74 (m, IH), 3.94 (d, IH, J= 7.6 Hz), 4.00 (dd, IH, J= 3.2 & 11.3 Hz), 4.18-4.21 (m, IH), 4.50-4.55 (m, 2H,), 4.89 (m, IH), 7.26-7.55 (m, 12H), 7.69 (s, IH). 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl-5-(S)-phenyl- morpholine NMR (CDC13, 400 MHz, ppm): δ 3.68 (dd, IH, J= 3.0 & 11.0 Hz), 3.88-3.94 (m, IH), 4.26-4.30 (m, IH), 4.36 (s, IH), 4.52 (d, IH, J= 13.5 Hz), 4.77-4.86 (m, 2H), 7.27-7.51 (m, 12H), 7.69 (s, IH). 2-(R or S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(S)- phenylmorpholine NMR (CDCI3, 400 MHz, ppm): δ 3.93-3.95 (m, IH), 4.06-4.21 (m, 2H), 4.38-4.42 (m, IH), 4.59-4.68 (m, 2H), 4.83-4.94 (m, 2H), 7.25- 7.81 (m, 13H). 2-(R or S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-5-(S)- phenylmorpholine NMR (CDCI3, 400 MHz, ppm): δ 3.43-3.59 (m, 2H), 3.82 (d, IH, J= 7.2 Hz), 4.25 (d, IH, J= 12.5 Hz), 4.52-4.63 (m, 3H), 4.80-4.90 (br s, IH), 7.11-7.81 (m, 13H). EXAMPLE 31 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-6-(R)-methyl-3-(S)-phenyl-4- (3-(1.2.4-triazolo)methyl)-morpholine According to the procedure given in Example 17, Step B, 98 mg (0.24 mmole) of 2-(S)-(3,5-bis-(trifluoromethyl)benzyloxy)-3- (S)-phenyl-6-(R)-methyl moφholine (from Example 25 above), 38 mg (0.28 mmole) of N-formyl-2-chloroacetamidrazone (from Example 17, Step A above) and 97 mg (0.7 mmole) of anhydrous potassium carbonate gave, after flash chromatography on 28 g of silica eluting with 1 L of 100:4:0.5 methylene chloride:methanol: ammonia water, a light yellow solid which after recrystallization from hexanes/methylene chloride provided 77 mg (66%) of 2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-6-(R)-methyl-3-(S)-phenyl-4-(3-( 1,2,4- triazolo)methyl)moφholine as a white powder. NMR (CDC13, 400 MHz, ppm): δ 1.17 (d, J= 6.3, 3H), 2.29 (t, J= 11.1, IH), 2.92 (d, J= 11.1, IH), 3.42 (d, J= 15.3, IH), 3.58 (s, IH), 3.88 (d, J= 15.4, IH), 4.20-4.33 (m, IH), 4.43 (d, 13.5, IH), 4.71 (d, J= 2.4, IH), 4.74 (d, J= 13.3, IH), 7.30-7.55 (m, 7H), 7.69 (s, IH), 7.95 (s, IH). EXAMPLE 32 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-6-(R)-methyl-4-(3-(5-oxo- lH.4H-1.2.4-triazolo)methylV3-(SVphenylmoφholine A mixture of 96 mg (0.23 mmole) of 2-(S)-(3,5-bis- (trifluoromethyl)benzyloxy)-3-(S)-phenyl-6-(R)-methyl moφholine (from Example 25 above), 46 mg (0.28 mmole) of N-methylcarboxy-2- chloroacetamidrazone and 95 mg (0.69 mmole) of anhydrous potassium carbonate in 3 mL of dry DMF was stirred at room temperature for 20 min, at 60°C for 90 min and then at 120°C for 2 hr. The mixture was cooled to room temperature, taken up m 15 mL of ethyl acetate and was washed with 3x10 mL of water. The combined aqueous layers were back-extracted with 10 mL of ethyl acetate, the combined organic layers were washed with 10 mL of brine, dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by flash chromatography on 28 g of silica eluting with 1L of 100:4 methylene chloride: methanol to give 65 mg (55%) of 2-(S)-(3,5-bis(trifluoro- methyl)benzyl-oxy)-6-(R)-methyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)- methyl)-3-(S)-phenylmoφholine as a light yellow powder. NMR (CDC13, 400 MHz, ppm): δ 1.18 (d, J= 6.2, 3H), 2.15 (t, J= 11.1, IH), 2.89 (d, J= 14, 2H), 3.49 (d, J= 2.2, IH), 3.61 (d, J= 14.4, IH), 4.20-4.30 (m, IH), 4.45 (d, J= 13.6, IH), 4.67 (d, J= 2.5, IH), 4.79 (d, J= 13.5, IH), 7.25-7.50 (m, 7H), 7.62 (s, IH), 10.07 (s, IH), 10.35 (s, IH). EXAMPLE 33 2-(S)-(3.5-Bis(trifluoromethyl)benzyloxyV3-(RVphenylmoφholine Step A: 4-Benzyl-2-(S)-hvdroxy-3-(R)-phenylmoφholine A solution of 3.72 g (13.9 mmol) of 4-benzyl-3-(R)- phenyl-2-moφholinone, prepared from (R)-phenyl-glycine as described in Example 14, in 28 mL of CH2CI2 was cooled in a -78°C bath under a N2 atmosphere and 14 mL of a 1.5 M solution of DIBAL-H (21 mmol) in toluene were added. After stirring the resulting solution for 0.5 h, it was allowed to warm to -50°C and mantained at this temperature for 0.5 h. The reaction mixture was quenched by adding 10 mL of aqueous potassium sodium tartarate. The mixture was diluted with CH2CI2 and the layers were separated. The aqueous layer was extracted 3 times with CH2CI2. The CH2CI2 layers were washed with brine, dried over Na2Sθ4 and filtered. Concentration of the filtrate furnished 3.32 g (88%) of 4-benzyl-2-(S)-hydroxy-3-(R)-phenylmoφholine suitable for use in the next step. NMR (CDCI3) 2.28 (m, IH), 2.71 (m, IH), 2.91 (d, J = 13 Hz, IH), 3.09 (d, J = 6 Hz, IH), 3.69 (d, J = 13 Hz, IH), 3.82 (td, J = 10 Hz and 2 Hz, IH), 3.91 (d, J = 10 Hz, IH), 4.73 (t, J = 6 Hz, IH), 7.2-7.52 (m, 10H). Step B: 4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)-benzyloxy)-3-(R)- phenylmorpholine To a suspension of 0.592 g (14.8 mmol) of NaH in 30 mL of dry THF at 0°C was added 3.32 g (12.3 mmol) of 4-benzyl-2-(S)- hydroxy-3-(R)-phenyl-moφholine prepared in step A. After 15 min 0.915 g of tetrabutylammonium iodide (2.47 mmol) and 2.4 mL (13 mmol) of 3,5-bis(trifluoromethyl)benzyl bromide were added. The resulting mixture was stirred at ice-bath temperature for 1 h, then poured into saturated NaHCθ3 solution and extracted with ethyl acetate (EtOAc). The organic layers were combined, washed with brine, dried over Na2Sθ4 and filtered. The filtrate was concentrated in vacuo and the resiue was chromatographed on a Waters Prep500 HPLC system using 50% EtOAc/Hexane to isolate 3.6 g (59%) of 4-Benzyl-2-(S)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(R)-phenylmoφholine. lH NMR (CDC13) 2.3 (td, J = 11 Hz and 3 Hz, IH), 2.71 (d, J = 11 Hz, IH), 2.90 (d, J = 13 Hz, IH), 3.22 (d, J = 7.3 Hz, IH), 3.75 (m, 2H), 3.93 (m, IH), 4.43 (d, J = 13 Hz, IH), 4.45 (d, J = 7.3 Hz, IH), 4.82 (d, J = 13 Hz, 1 H), 7.19-7.5 (m, 12H), 7.67 (s, IH). Step C: 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(R)-phenyl- morpholine A solution of 3.6 g (7.27 mmol) of 4-benzyl-2-(S)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(R)-phenylmoφholine in 100 mL of ethanol and 5 mL of water, containing 0.72 g of 10% Pd/C was hydrogenated on a Parr apparatus for 36 h. The catalyst was filtered and thoroughly washed with EtOAc. The filtrate was concentrated and the residue was partitioned between water and EtOAc. The EtOAc layer was washed with brine, dried over Na2Sθ4, filtered and concentrated. The residue was purified by flash chromatography using a gradient of 10-60 % EtOAc/hexane to isolate 2.05 g (70%) of 2-(S)- (3,5-bis(trifluoromethyl)benzyloxy)-3-(R)-phenylmoφholine. lH NMR (CDC13) 1.92 (br s, IH), 2.91 (m, IH), 3.05 (td, J =HHz and 3 Hz, IH), 3.68 (d, J = 7 Hz, IH), 3.81 (td, J = 11 Hz and 3 Hz, IH), 4.01 (m, IH), 4.44 (d, J = 7 Hz), 4.5 (d, J = 13 Hz, IH), 4.85 (d, J = 13 Hz, 1 H), 7.28-7.42 (m, 7H), 7.67 (s, IH). EXAMPLE 34 4-(3-(l,2,4-Triazolo)methyl)-2-(S)-(3,5-bis(trifluoromethyl)- benzyloxy)-3-(R)-phenylmorpholine The title compound was prepared by the procedure of Example 17, step B employing the product of Example 33, step C as a starting material. lH NMR (CDC13) 1.75 (br s, 1 H), 2.61 (td, J =12 Hz and 2 Hz, IH), 2.83 (d, J = 12 Hz, IH), 3.33 (d, J = 7 Hz, IH), 3.48 (d, J = 15 Hz, IH), 3.78 (d, J = 15 Hz, IH), 3.85 (m, IH), 3.99 (m, IH), 4.44 (d, J = 13 Hz, 1 H), 4.49 (d, J = 7Hz, IH), 4.81 (d, J = 13 Hz, IH), 7.23-7.45 (m, 7H), 7.67 (s, IH), 7.96 (s,lH). EXAMPLE 35 4-(3-(5-Oxo-lH,4H-l,2,4-triazolo)methyl)-2-(S)-(3,5-bis-(trifluoro- methyl)benzyloxy)-3-(R)-phenyl-morpholine The title compound was prepared by the procedure of Example 18, steps B & C employing the product of Example 33, step C as a starting material. EXAMPLE 36 4-(2-(Imidazolo)methyl)-2-(S)-(3,5-bis(trifluoro-methyl)benzyloxy)-3- (S)-phenylmorpholine A solution of 101 mg (0.25 mmol) of 2-(S)-(3,5-bis(tri- fluoromethyl)benzyloxy)-3-(S)-phenylmoφholine (Example 15), 98 mg (1.0 mmol) of imidazole-2-carboxaldehyde, and 5 drops of glacial acetic acid in 3 ml of methanol was treated with 1.5 ml of 1M. sodium cyanoborohydride solution in THF. After 16 hr, the reaction was quenched with 5 ml of saturated aqueous sodium bicarbonate solution and partitioned between 40 ml of ethyl acetate and 20 ml of water. The organic layer was separated, dried over magnesium sulfate, and concentrated in vacuo. Rash chromatography on 8 g of silica gel using 50: 1 :0.1 methylene chloride/methanol amonium hydroxide as the eluent afforded 54 mg (44% yield) of the title compound as a white solid. lH NMR (CDC13) 2.60 (dt, J = 3.2 Hz and 12.4 Hz, IH), 2.85 (d, J =12.4 Hz, IH), 3.28 (d, J = 14.4 Hz, IH), 3.59 (d, J =2.8 Hz, IH), 3.66 (dd, J =2.0, 11.6 Hz, IH), 3.84 (d, J =14.4 Hz, IH), 3.94 (app s, 2H), 4.14 (dt, J = 2.0, 12.0 Hz, IH), 4.43 (d, J = 13.6 Hz, IH), 4.71 (d, J = 2.8 Hz, IH), 4.78 (d, J = 13.6 Hz, IH), 6.99 (app s, 2H), 7.25-7.48 (m, 6H), 7.72 (s, IH). Mass spectrum (FAB): m/z 486 (100%, M+H) EXAMPLE 37 4-(2-(Imidazolo)methyl)-2-(S)-(3,5-bis(trifluoro-methyl)benzyloxy)-3- (R)-phenylmorpholine The title compound was prepared by the procedure of Example 36 employing appropriate starting materials. lH NMR (CDCI3) 2.53 (td, J = 11 Hz and 3 Hz, IH), 2.74 (d, J =12 Hz, IH), 3.23 (d, J = 7Hz, IH), 3.32 (d, J =15 Hz, IH), 3.66 (d, J =15 Hz, IH), 3.77 (td, J =11 Hz and 2 Hz, IH), 3.99 (m, IH), 4.44 (m, 2H), 4.8 (d, J = 13 Hz, IH), 6.94 (s, 2H), 7.2-7.45 (m, 7H), 7.67 (s, IH). EXAMPLE 38 4-(5-(Imidazolo)methyl)-2-(S)-(3,5-bis(trifluoro-methyl)benzyloxy)-3- (R)-phenylmorpholine The title compound was prepared by the procedure of Example 36 employing appropriate starting materials. lH NMR (CDCI3) 2.47 (td, J = 12 Hz and 3 Hz, IH), 2.83 (d, J = 12 Hz, IH), 3.2 (m, 2H), 3.61 (d, J =14 Hz, IH), 3.79 (td, J =12 Hz and 2 Hz, IH), 3.96 (m, IH), 4.44 (m, 2H), 4.80 (d, J =13 Hz, IH), 6.81 (s, IH), 7.28-7.45 (m, 7H), 7.60 (s, IH), 7.66 (s, IH). EXAMPLE 39 4-(Aminocarbonylmethyl)-2-(S)-(3,5-bis(trifluoro-methyl)benzyloxy)- 3-(R)-phenylmorpholine The title compound was prepared by the procedure of Example 15 employing appropriate starting materials. lH NMR (CDCI3) 2.54 (td, J = 11 Hz and 2 Hz, IH), 2.64 (d, J = 17 Hz, IH), 2.93 (d, J 12 Hz, IH), 3.14 (d, J = 17 Hz, IH), 3.27 (d, J =7 Hz, IH), 3.83 (td, J = 11 Hz and 2 Hz, IH), 4.05 (m, IH), 4.46 (m, 2H), 4.81 (d, J =13 Hz, IH), 5.62 (br s, IH), 6.80 (br s, IH), 7.28-7.32 (m, 7H), 7.67 (s, IH). EXAMPLES 40-43 4-(3-(l,2,4-Triazolo)methyl)-2-(3-(tert-butyl)-5-methylbenzyloxy)-3- phenyl-moφholine, 4-(3-(5-Oxo-lH,4H-l,2,4-triazolo)methyl)-2-(3- (tert-butyl)-5-methylbenzyloxy)-3-phenyl-moφholine, 4-(2- (Imidazolo)methyl)-2-(3-(tert-butyl)-5-methyl-benzyloxy)-3-phenyl- moφholine, 4-(4-(Imidazolo)-methyl)-2-(3-(tert-butyl)-5-methyl- benzyloxy)-3-phenyl-morpholine The title compounds are each prepared by the procedures of Examples 15, 17 & 18 employing appropriately substituted starting materials and reagents. EXAMPLE 44 2-(S)-(3.5-Dichlorobenzyloxy -3-(S -phenylmoφholine Step A: 3,5-Dichlorobenzyl alcohol, trifluoromethanesulfonate ester A solution of 6.09 g (34.4 mmole) of 3,5-dichlorobenzyl alcohol and 8.48 g (41.3 mmole) of 2,6-di-t-butyl-4-methylpyridine in 280 mL of dry. carbon tetrachloride under, a nitrogen atmosphere was treated with 5.95 mL (35.4 mmole) of trifluoromethanesulfonic anhydride at room temperature. A white precipitate formed shortly after the addition of the anhydride. After 90 min, the slurry was filtered under nitrogen with a Schlenk filter, and the filtrate was concentrated in vacuo. The residue, which was a two-phase oil, was dissolved under nitrogen in 60 mL of dry toluene. The resulting solution was used immediately in Step B below. Step B: 4-Benzyl-2-(S)-(3,5-dichlorobenzyloxy)-3-(S)-phenyl- morpholine A solution of 5.11 g (19.1 mmole) of N-benzyl-3-(S)- phenylmoφholin-2-one (from Example 14) in 100 mL of dry THF was cooled to -75°C under nitrogen and was treated dropwise with 20.5 mL (20.5 mmole) of a 1M solution of lithium tri(sec-butyl)borohydride (L- Selectride®) in THF. After stirring the solution at -75°C for 30 min, a solution of 3,5-dichlorobenzyl alcohol, trifluoromethanesulfonate ester in toluene (from Example 44, Step A) was added by cannula so that the internal temperature was maintained below -60°C. The resulting solution was stirred between -38°C and -50°C for 9 hr, and was then treated with 14 mL of aqueous ammonia and stored at -20°C for 12 hours. The solution was then poured into a mixture of 50 mL of ethyl acetate and 100 mL of water, and the layers were separated. The aqueous phase was extracted with 2x100 mL of ethyl acetate, each extract was washed with brine, the combined organic layers were dried over sodium sulfate, the mixture was filtered and the filtrate concentrated in vacuo. The residue was purified by flash chromato¬ graphy on 235 g of silica eluting with 1.5 L of 100:2 hexanes:ethyl acetate, then 1.5 L of 100:3 hexanes:ethyl acetate and then 1.9 L of 100:5 hexanes:ethyl acetate to give 4.4 g (54%) of an oil, which by lH NMR is a 8:1 mixture of cis:trans moφholines. Mass Spectrum (FAB): m Z 430,428,426 (M+H, -60%), 268 (M- ArCH2, 100%), 252 (M-ArCH2θ, 75%), 222(20%), 159 (45%). lH NMR (CDCI3, 400 MHz, ppm): δ major (cis) isomer: 2.32 (td, J= 12, 3.6, IH), 2.84 (app t, J= 13, 2H), 3.52 (d, J= 2.6, IH), 3.55 (dq, J= 11.3, 1.6, IH), 3.91 (d, J= 13.3, IH), 4.12 (td, J= 11.6, 2.4, IH), 4.29 (d, J= 13.6, IH), 4.59 (d, J= 2.9, IH), 4.60 (d, J= 13.6), 6.70 (s, 2H), 7.13 (t, J= 1.9, IH), 7.2-7.6 (m, 8H), 7.53 (br d, 2H). Step C: 2-(S)-(3.5-Dichlorobenzyloxy)-3-(S)-phenyl-moφholine A solution of 0.33 g (0.77 mmole) of 4-benzyl-2-(S)-(3,5- dichlorobenzyloxy)-3-(S)-phenylmoφholine (from Example 44, Step B) and 0.22 g (1.54 mmole) of 1-chloroethyl chloroformate in 4.5 mL of 1,2-dichloroethane was placed in a pressure vial which was lowered into an oil bath which was heated to 110°C. After stirring for 60 hr the solution was cooled and concentrated in vacuo. The residue was dissolved in 7 mL of methanol and the resulting solution was heated at reflux for 30 min. The mixture was cooled and treated with several drops of concentrated aqueous ammonia and the solution was concentrated. The residue was partly purified by flash chromatography on 67 g of silica eluting with 1.5 L of 100:1 methylene chloride: methanol, and the rich cuts were purified by flash chormatography on 32 g of silica eluting with 50:50 hexanes: ethyl acetate and then 50:50:5 hexanes:ethyl acetate:methanol to give 0.051 g (20%) of an oil, which by lH NMR was pure cis moφholine. Mass Spectrum (FAB): m Z 468,466,464 (max 8%)), 338,340 (M+H, 25%), 178 (20%), 162 (100%), 132 (20%),. lH NMR (CDC13, 400 MHz, ppm): δ 1.89 (br s, IH), 3.08 (dd, J= 12.5, 2.9, IH), 3.23 (td, J= 12.2, 3.6, IH), 3.59 (dd, J= 11.3, 2.5, IH), 4.03 (td, J= 11.7, 3, IH), 4.09 (d, J= 2.4, IH), 4.37 (d, J= 13.5, IH), 4.62 (d, J= 13.3, IH), 4.67 (d, J= 2.5, IH), 6.72 (d, J= 1.8, 2H), 7.14 (t, J= 1.8, IH), 7.25-7.40 (m, 5H). EXAMPLE 45 2-(S)-(3,5-dichlorobenzyloxy)-4-(3-(5-oxo-l,2,4-triazolo)methyl)-3- (S)-phenylmorpholine Step A: N-Methylcarbϋxy-2-chloroacetamidrazone A solution of 5.0 g (66.2 mmol) of chloroacetonitrile in 35 mL of dry methanol was cooled to 0°C and was treated with 0.105 g (1.9 mmol) of sodium methoxide. The ice-bath was removed and the mixture was alowed to stir at room temperature for 30 minutes. To the reaction was then added 0.110 mL (1.9 mmol) of acetic acid and then 5.8 g (64.9 mmol) of methyl hydrazinecarboxylate. After stirring 30 minutes at room temperature, the suspension was concentrated in vacuo. and placed on the high-vac line overnight, to give 10.5 g (98%) of a yellow powder, a portion of which was employed in Step C below. Step B: 4-(2-(N-Methylcarboxy-acetamidrazono)-2-(S)-(3,5- dichlorobenzyloxy)-3-(SVphenylmoφholine A solution of 0.050 g (0.15 mmol) of 2-(S)- (3,5-dichlorobenzyloxy)-3-(S)-phenylmoφholine (from Example 44, Step C), 0.034 g (0.21 mmol) of N-methyl-carboxy-2-chloro- acteamidrazone (from Step A), and 0.044 mL (0.25 mmol) N,N- diisopropylethylamine in 1 mL of acetonitrile was stirred at room temperature for 3 hours. The mixture was partitioned between 20 mL of methylene chloride and 10 mL of water. The layers were separated, the organic layer was dried over sodium sulfate and was then concentrated in vacuo. The residue was purified by flash chromato¬ graphy on 35 g of silica eluting with 1L of 50:1: methylene chloride/methanol then 500 mL of 25:1:0.05 methylene chloride:methanol: aqueous ammonia to give 70 mg (-100%) of the product as a white solid. Mass Spectrum (FAB): m/Z 469 (M+H, 60%), 467 (M+H, 100%),291 (40%), 160 (20%), 158 (25%). IH NMR (CDC13, 400 MHz, ppm): δ 2.48 (td, J= 3.5, 12.2, IH), 2.53 (d, J= 14.6, IH), 2.90 (d, J= 11.8, IH), 3.37 (d, J= 14.6, IH), 3.52 (d, J= 2.8), IH), 3.62 (dm, J= 11.4, IH), 3.75 (s, 3H), 4.14 (td, J= 2.2, 11.8, IH), 4.28 (d, J= 13.5, IH), 4.58 (d, J= 13.6), 4.60 (d, J= 2.8, IH), 5.45 (br s, 2H), 6.74 (d, J= 1.9, 2H), 7.15 (t, J= 1.9, IH), 7.30-7.46 (m, 6H). Step C: 2-(S)-(3,5-Dichlorobenzyloxy)-4-(3-(5-oxo-l,2,4-triazolo)- methyl -3-(SVphenylmorpholine A solution of 0.069 g (0.15 mmol) of 4-(2-(N-methyl- carboxyacetamidrazono)-2-(S)-(3,5-dichlorobenzyloxy)-3-(S)- phenylmoφholine (from Step B) in 6 mL of xylenes was heated at reflux for 2 hours. The solution was cooled and concentrated in vacuo. The residue was purified by flash chromatography on 35 g of silica gel eluting with 500 mL of 50:1:0.1 methylene chloride/methanol/aqueous ammonia then 500 mL of 20:1:0.1 methylene chloride/methanol/aqueous ammonia to give 56 mg (88%) of the product as a white powder. Mass Spectrum (FAB): m/Z 437 (M+H, 65%), 435 (M+H, 100%), 259 (85%), 161 (55%). lH NMR (CDC13, 400 MHz, ppm): δ 2.53 (t, J= 11.7, 3.6, IH), 2.88 (d,J= 11.6, IH), 2.96 (d, J= 14.3, IH), 3.54 (d, J= 2.6, IH), 3.63 (dd, J= 11.6, 1.9, IH), 3.68 (d, J= 14.6, IH), 4.16 (t, J= 11.7, 2.2, IH), 4.30 (d, J= 13.6), 4.58 (d, J= 2.7, IH), 4.67 (d, J= 13.6, IH), 6.65 (d, J= 1.8, 2H), 7.07 (t, J= 1.9, IH), 7.29-7.44 (m, 5H), 10.25 (br s, IH), 10.75 (br s, IH). EXAMPLE 46 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(methoxy-carbonyl- methyl)-3-(SVphenylmorpholine A solution of 300 mg (0.74 mmole) of 2-(S)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-moφholine (from Example 15, Step C) and 0.35 mL (2.0 mmole) of DIEA in 5 mL of acetonitrile was treated with 0.19 mL (2.0 mmole) of methyl bromoacetate and the mixture was stirred for 16 hr at room temperature. The solution was then concentrated in vacuo and the residue partitioned between 30 mL of ether and 15 mL of 0.5 N aqueous KHSO4. The layers were separated and the organic phase was washed with 10 mL of brine and dried over magnesium sulfate. Following filtration, the organic phase was concentrated in vacuo and the residue purified by flash chromatography on 20 g of silica eluting with 80:20 hexanes:ether to give 351 mg (99%) of the product. [a]D = +147.3° (c= 1.6, CHCI3). Mass Spectrum (FAB): m/Z 478 (M+H, 40%), 477 (65%), 418 (50%), 250 (95%), 234 (90%), 227 (100%). lH NMR (CDCI3, 400 MHz, ppm): δ 3.02 (br d, 2H), 3.13 (d, J= 16.9, IH), 3.36 (d, J= 16.8), 3.62 (s, 3H), 3.69 (dt, J= 11.7, 2.2, IH), 4.03 (br s, IH), 4.23-4.32 (m, IH), 4.44 (d, J= 13.3, IH), 4.68, (d, J= 2.6, IH), 4.81 (d, J= 13.5, IH), 7.30-7.38 (m, 3H), 7.4-7.5 (m, 3H), 7.70 (s, IH). Analysis Calcd for C22H21 F6NO4: C, 55.35; H, 4.43; N, 2.93; F, 23.88 Found: C, 55.09; H, 4.43; N, 2.83; F, 24.05 EXAMPLE 47 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(carboxymethyl)-3-(S)- phenylmorpholine A solution of 0.016 g (0.034 mmole) of 2-(S)-(3,5- Bis(trifluoromethyl)benzyloxy)-4-(methoxy-carbonylmethyl)-3-(S)- phenylmoφholine (from Example 46) in 2 mL of THF and 0.5 mL of water was treated with 0.027 mL (0.067 mmole) of 2.5 N aqueous sodium hydroxide and the mixture was stirred at room temperature for 5 hr. The mixture was treated with 2 drops of 2N aqueous HCl and 3 mL of water and the solution was extracted with 15 mL of 1:1 hexanes:ethyl acetate. The organic phase was dried over magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by flash chormatography on 13 g of silica eluting with 250 mL of 100:3:0.1 methylene chloride:methanol:acetic acid then 100 mL of 50:2:0.1 methylene chloride:methanol:acetic acid to give 0.014 g (90%) of an oil. Mass Spectrum (FAB): m/Z 464 (M+H, 90%), 420 (M-CO2, 10%), 227 (ArCH2, 35%), 220 (M-OCH2Ar, 100%), 161 (20%). lH NMR (CDCI3, 400 MHz, ppm): δ 2.9 (app d, 2H), 3.03 (d, IH), 3.33 (d, IH), 3.72 (d, IH), 3.90 (d, IH), 4.25 (t, IH), 4.44 (d, IH), 4.71 ( d, IH), 4.79 (d, IH), 7.3-7.4 (m, 5H), 7.44 (s, 2H), 7.71 (s, IH). EXAMPLE 48 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-((2-aminoethyl)amino- carbonylmethyl)-3-(S -phenylmorpholine hydrochloride A solution of 54 mg (0.11 mmole) of 2-(S)-(3,5-bis(tri- fluoromethyl)benzyloxy)-4-(carboxymethyl)-3-(S)-phenylmoφholine (from Example 46) and 0.15 mL of ethylenediamine (2.3 mmole) in 1 mL of methanol was stirred at 55 °C for 48 hr. The mixture was concentrated and the residue purified by flash chromatography on 16 g of silica eluting with 500 mL of 50:4:0.1 methylene chloride:methanol: aqueous ammonia to provide 57 mg(100%) of an oil. The oil was dissolved in ether and was treated with ether saturated with gaseous HCl. After concentration in vacuo. 58 mg (95%) of a rigid oil was obtained. Mass Spectrum (FAB; free base): m/Z 506 (M+H, 100%), 418 (15%), 262(35%), 227 (30%), 173 (40%) lH NMR (CDCI3, 400 MHz, ppm): δ 2.56 (d, J= 15.5, IH), 2.59 (td, J= 12.0, 3.6, IH), 2.82 (t, J= 6.5, 2H), 2.96 (d, J= 11.8, IH), 3.21 (d, J= 15.8, IH), 3.25-3.40 (m, 2H), 3.65 (d, J= 2.6, IH), 3.67 (app dt, J= 11,4, -2, IH), 4.18 (td, J= 11.8, 2.6, IH), 4.33 (d, J= 13.5, 1H),4.69 (d, J= 2.7, IH), 4.79 (d, J= 13.5, IH), 7.25-7.40 (m, 5H), 7.46 (s, 2H), 7.59 (br t, IH), 7.71 (s, IH). EXAMPLE 49 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-((3-amino-propyl)amino carbonylmethv -3-(S)-phenylmoφholine hvdrochloride ' _ A solution of 59 mg (0.12 mmole) of 2-(S)-(3,5-bis(tri- fluoromethyl)benzyloxy)-4-(carboxymethyl)-3-(S)-phenylmoφholine (from Example 46) and 0.21 mL of 1,3-propylenediamine (2.5 mmole) in 1 mL of methanol was stirred at 55°C for 72 hr. The mixture was concentrated and the residue purified by flash chromatography on 16 g of silica eluting with 500 mL of 10:1:0.05 methylene chloride:methanol: aqueous ammonia to provide 56 mg (88%) of an oil. The oil was dissolved in methylene chloride and was treated with methylene chloride saturated with gaseous HCl. After concentration in vacuo. a white paste was obtained. Mass Spectrum (FAB; free base): m/Z 520 (M+H, 100%), 418 (10%), 276(30%), 227 (20%), 174 (30%) lH NMR (CDCI3, 400 MHz, ppm): δ 1.64 (pentet, J= 6.6, 2H), 2.53 (d, J= 15.5, IH), 2.58 (td, J= 12.0, 3.6, IH), 2.73 (t, J= 6.5, 2H), 2.92 (d, J= 11.8, IH), 3.19 (d, J= 15.8, IH), 3.25-3.40 (m, 2H), 3.62 (d, J= 2.6, IH), 3.65 (app dt, J= 11.4, -2, IH), 4.16 (td, J= 11.8, 2.6, IH), 4.41 (d, J= 13.5, 1H),4.68 (d, J= 2.7, IH), 4.79 (d, J= 13.5, IH), 7.25-7.40 (m, 5H), 7.45 (s, 2H), 7.57 (br t, IH), 7.70 (s, IH). EXAMPLE 50 4-benzyl-5-(S),6-(R)-dimethyl-3-(S)-ρhenylmoφholinone and 4-benzyl- 5-(R .6-(Sydimethyl-3-(S)-phenylmorpholinone To a suspension of 1.7 g (7.0 mmole) of N-benzyl-(S)- phenylglycine (Example 13) in 15 ml of methylene chloride at 0°C was added 6.9 ml (13.9 mmole) of trimethylaluminum (2.0 M in toluene). After one hour at 0 ό C, 0.625 ml (7.0 mmole) of (+/-)-trans-2,3-eρoxy butane (dissolved in 2.0 ml of methylene chloride) was added dropwise and then allowed to stir at 22°C for 16 hours. The reaction was then transferred to another flask containing 30 ml of 1:1 hexane:methylene chloride and 30 ml of 1M potassium sodium tartrate and stirred at 22°C for 2 hours. The layers were separated, and the aqueous layer was extracted with methylene chloride (3 x 100 ml). The combined organic layers were washed with 25 ml of a saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude alcohol was dissolved in 25 ml of toluene, treated with 93 mg (0.49 mmole) of p-toluenesulfonic acid and heated at 50°C for 20 hours. The reaction was then cooled and concentrated in vacuo . The residue was partitioned between 15 ml of diethyl ether and 10 ml of saturated sodium bicarbonate. The layers were separated, and the organic layer was washed with water (3 x 10 ml). The combined organic layers were washed with 25 ml of a saturated sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo. Flash chromatography on 145 g of silica gel using 1 :4 v/v ethyl acetate/ hexane as the eluant afforded 567 mg of the high Rf lactone (Isomer A) and 388 mg of the low Rf lactone (Isomer B). lH-NMR (400 MHz, CDCI3) δ Isomer A: 1.04 (d, 3H, J = 8.0 Hz), 1.24 (d, 3H, J = 8.0 Hz), 2.92 (br qd, IH), 3.41 (d, IH, J = 16.0 Hz), 3.62 (d, IH, J = 16.0 Hz), 4.38 (s, IH), 4.96 (br qd, IH), 7.20-7.42 (m, 8H), 7.58-7.64 (m, 2H); Isomer B: 1.04 (d, 3H, J = 10.0 Hz), 1.39 (d, 3H, J = 10.0 Hz), 3.06 (br qd, IH), 3.53 (d, IH, J = 16.0 Hz), 3.81 (d, IH, J = 16.0 Hz), 4.33 (s, IH), 4.67 (br qd, IH), 7.18-7.50 (m, 10H). Mass Spectrum (FAB): m/z Isomer A: 296 (M+H, 100%), 294 (50%); Isomer B: 296 (M+H, 100%), 294 (50%). EXAMPLE 51 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-[5-(S),6-(R) or 5-(R),6-(S)- dimethyll - 3- (S Vphenylmoφholinone Step A: 4-Benzyl-2-(R)-(3,5-bis(trifluoromethyl)-benzyloxy)-[5- (S),6-(R) or 5-(R),6-(S)-dimethyl]-3-(S)-phenyl- morpholinone According to the procedure in Example 15, Step B, 251 mg (0.85 mmole) of Isomer A from Example 50 (4-benzyl-[5-(S),6-(R) or 5-(R)-6-(S)-dimethyl]-3-(S)-phenylmoφholinone) provided 238 mg (53%) of the product as an oil. lH-NMR (400 MHz, CDCI3) δ 1.03 (d, 3H, J = 6.7 Hz), 1.13 (d, 3H, J = 6.6 Hz), 2.61 (qd, IH, J = 2.2 & 6.6 Hz), 3.26 (d, IH, J = 13.9 Hz), 3.55 (d, IH, J = 13.9 Hz), 3.63 (d, IH, J = 7.6 Hz), 4.01 (qd, IH, J = 2.3 & 6.6 Hz), 4.44 (d, IH, J = 13.1 Hz), 4.53 (d, IH, J = 7.7 Hz), 4.71 (s, IH), 4.85 (d, IH, J = 13.2 Hz), 7.20-7.35 (m, 9H), 7.46-7.48 (m, 2H), 7.67 (s, IH), 7.81 (s, IH). Mass Spectrum (FAB): m/z 523 (M+H, 100%), 296 (95%), 280 (40%), 227 (50%). Step B: 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-[5-(S),6-(R) or 5-(R).6-(S)-dimethyl1-3-(S)-phenylmoφholinone According to the procedure in Example 15, Step C, 260 mg of starting material from Step A [derived from Isomer A in Example 50 (4-Benzyl-2-(R)-(3,5-bis(trifluoromethyl)benzyloxy)-[5-(S),6-(R) or 5- (R),6-(S)-dimethyl]-3-(S)-phenylmoφholinone)] provided 122 mg (57%) of the product as an oil. lH-NMR (400 MHz, CDC13) δ 1.19 (d, 3H, J = 6.5 Hz), 1.27 (d, 3H, J = 6.7 Hz), 2.97 (qd, IH, J = 2.9 & 6.9 Hz), 3.96 (d, IH, J = 7.7 Hz), 4.08- 4.11 (m, 2H), 4.39 (d, IH, J = 7.7 Hz), 4.50 (d, IH, J = 13.3 Hz), 4.88 (d, IH, J = 13.2 Hz), 7.27-7.33 (m, 3H), 7.40-7.42 (m, 4H), 7.67 (s, IH). Mass Spectrum (FAB): m/z 434 (M+H, 45%), 227 (35%), 206 (40%), 190 (100%). EXAMPLE 52 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-[5-(R),6-(S) or 5-(S),6-(R)- dimethyll-3-(S -phenylmorpholinone Step A: 4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)-benzyloxy)-[5- (R),6-(S) or 5-(S),6-(R)-dimethyl]-3-(S)-phenyl- morpholinone According to the procedure in Example 15, Step B, 449 mg (1.52 mmole) of Isomer B from Example 50 (4-benzyl-[5-(R),6-(S) or 5-(S)-6-(R)-dimethyl]-3-(S)-phenylmoφholinone) provided 400 mg (51 %) of the product as an oil. lH-NMR (400 MHz, CDCI3) δ 0.90 (d, 3H, J = 6.8 Hz), 1.37 (d, 3H, J = 6.6 Hz), 2.86-2.89 (br qd, IH), 3.47 (d, IH, J = 15.0 Hz), 3.82-3.85 (m, 2H), 3.99-4.02 (br qd, IH), 4.45 (d, IH, J = 13.6 Hz), 4.81 (d, IH, J = 2.0 Hz), 4.87 (d, IH, J = 13.5 Hz), 7.17-7.83 (m, 13H). Step B: 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-[5-(S),6-(R) or 5-(R .6-(S)-dimethyl1-3-(S)-phenylmoφholinone According to the procedure in Example 15, Step C, 400 mg of starting material from Step A [derived from Isomer B in Example 50 (4-Benzyl-2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-[5-(R),6-(S) or 5- (S),6-(R)-dimethyl]-3-(S)-phenylmoφholinone)] provided 230 mg (69%) of the product as an oil. lH-NMR (400 MHz, CDCI3) δ 1.08 (d, 3H, J = 6.7 Hz), 1.38 (d, 3H, J = 7.0 Hz), 3.41-3.45 (br qd, IH), 3.85-3.89 (br qd, IH), 4.16 (d, IH, J = 2.9 Hz), 4.49 (d, IH, J = 13.6 Hz), 4.71 (d, IH, J = 2.9 Hz), 4.82 (d, IH, J = 13.6 Hz), 7.25-7.36 (m, 7H), 7.66 (s, IH). Mass Spectrum (FAB): m z 434 (M+H, 35%), 227 (40%), 206 (40%), 190 (100%). EXAMPLE 53 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(3-(l,2,4-triazolo)- methyl)-[5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3-(S)-phenyl- morpholinone A mixture of 62 mg (0.14 mmole) of 2-(R)-(3,5-Bis(tri- fluoromethyl)benzyloxy)-[5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3-(S)- phenylmoφholinone (from Example 51, Step B), 62 mg (0.45 mmole) of anhydrous potassium carbonate and 26 mg (0.19 mmole) of N- formyl-2-chloroacetamidrazone (from Example 17, Step A) in 2.0 ml of N,N-dimethylformamide was heated to 60°C for 2 hours and then 118°C for 1.5 hours. The mixture was then allowed to cool to room temperature and then quenched with 5 mis of water and diluted with 15 mis of ethyl acetate. The layers were separated and the organic layer was washed with ethyl acetate (2 x 10 mis). The combined organic layers were washed with 10 mis of brine, dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo. Flash chromatography on 42 g of silica gel using 95:5 v/v methylene chloride/ methanol as the eluant afforded 42 mg (57%) of a clear oil. lH-NMR (400 MHz, CDCI3) δ 1.13 (d, 3H, J = 6.5 Hz), 1.19 (d, 3H, J = 6.5 Hz), 2.65 (qd, IH, J = 1.9 & 6.5 Hz), 3.58 (d, IH, J = 15.5 Hz), 3.65 (d, IH, J = 7.7 Hz), 3.75 (d, IH, J = 15.4 Hz), 4.06 (qd, IH, J = 2.2 & 6.6 Hz), 4.45 (d, IH, J = 13.2 Hz), 4.54 (d, IH, J = 7.7 Hz), 4.84 (d, IH, J = 13.2 Hz), 7.28-7.37 (m, 7H), 7.67 (s, IH), 7.89 (s, IH). Mass Spectrum (FAB): m/z 516 (M+H, 52%), 287 (28%), 271 (100%), 227 (40%), 202 (38%). EXAMPLE 54 2-(R)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(3-(5-oxo-l,2,4-triazolo) methyl)-[5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3-(S)-phenyl- morpholinone A solution of 96 mg (0.22 mmole) of 2-(R)-(3,5- Bis(trifluoromethyl)benzyloxy)-[5-(S),6-(R) or 5-(R),6-(S)-dimethyl]-3- (S)-phenylmoφholinone (from Example 51, Step B), 92 mg (0.66 mmole) of potassium carbonate and 48 mg (0.29 mmole) of N- methylcarboxy-2-chloroacetamidrazone (from Example 18, Step A) in 4 mL of DMF was heated at 60°C for 1.5 hr and at 120°C for 3.5 hr. The mixture was cooled to room temperature and was partitioned between 15 mL of water and 25 mL of ethyl acetate. The aqueous layer was extracted with 3x10 mL of ethyl acetate, the combined organic layers were washed with 10 mL of brine, dried over sodium sulfate, filtered and concentrated in vacuo. The residue was partly purified by flash chromatography on 42 g of silica gel using 2L of 98:2 v/v methylene chloride/ methanol as the eluant and the rich cuts were purified under the same conditions to give 38 mg (33%) of a clear oil. lH-NMR (400 MHz, CDCI3) δ 1.09 (d, 3H, J = 6.5 Hz), 1.20 (d, 3H, J = 6.6 Hz), 2.64 (qd, IH, J = 2.4 & 6.6 Hz), 3.33 (s, IH), 3.56 (d, IH, J = 7.6 Hz), 4.11 (qd, IH, J = 2.4 & 6.6 Hz), 4.41 (d, IH, J = 13.2 Hz), 4.57 (d, IH, J = 7.7 Hz), 4.82 (d, IH, J = 13.2 Hz), 7.25-7.30 (m, 5H), 7.40 (d, 2H, J = 5.7 Hz), 7.65 (s, IH), 9.46 (s, IH), 10.51 (s, IH). Mass Spectrum (FAB): m/z 531 (M+H, 98%), 287 (100%), 227 (80%), 189 (65%). EXAMPLE 55 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(3-(l,2,4-triazolo)methyl)- T5-(R .6-(S or 5-(S .6-(R)-dimethyl1-3-(SVphenylmoφholinone According to the procedure in Example 53, 75 mg (0.17 mmole) of 2-(S)-(3,5-Bis(trifluoromethyl)-benzyloxy)-[5-(R),6-(S) or 5-(S),6-(R)-dimethyl]-3-(S)-phenylmoφholinone (from Example 52, Step B) provided, after flash chromatography on 73 g of silica gel using 98:2 v/v methylene chloride/ methanol as the eluant , 46 mg (52%) of a yellow oil. lH-NMR (400 MHz, CDCI3) δ 1.04 (d, 3H, J = 6.6 Hz), 1.46 (d, 3H, J = 6.7 Hz), 3.05-3.08 (m, IH), 3.74-3.81 (m, 2H), 3.91-3.95 (m, 2H), 4.41 (d, IH, J = 13.2 Hz), 4.69 (d, IH, J = 3.2 Hz), 4.82 (d, IH, J = 13.5 Hz), 7.31-7.35 (m, 5H), 7.43-7.45 (m, 2H), 7.68 (s, IH), 7.91 (s, IH). Mass Spectrum (El): m/z 432 (36%), 287 (60%), 270 (65%), 227 (30%), 187 (48%), 83 (100%). EXAMPLE 56 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(3-(5-oxo-l,2,4-triazolo) methyl)-[5-(R),6-(S) or 5-(S),6-(R)-dimethyl]-3-(S)-phenyl- morpholinone According to the procedure in Example 54, 86 mg (0.2 mmole) of 2-(S)-(3,5-Bis(trifluoromethyl)-benzyloxy)-[5-(R),6-(S) or 5-(S),6-(R)-dimethyl]-3-(S)-phenylmoφholinone (from Example 47, Step B) provided, after flash chromatography on 73 g of silica gel using 95:5 v/v methylene chloride/ methanol as the eluant, 32 mg (30%) of a yellow oil. lH-NMR (400 MHz, CDCI3) δ 1.03 (d, 3H, J = 6.7 Hz), 1.40 (d, 3H, J = 6.8 Hz), 3.00 (qd, IH, J = 3.8 & 6.8 Hz), 3.44 (d, IH, J = 16.1 Hz), 3.63 (d, IH, J = 16.0 Hz), 3.82 (d, IH, J = 3.3 Hz), 3.95 (qd, IH, J = 3.7 & 6.7 Hz), 4.43 (d, IH, J = 13.5 Hz), 4.73 (d, IH, J = 3.3 Hz), 4.84 (d, IH, J = 13.6 Hz), 7.28-7.47 (m, 7H), 7.68 (s, IH), 9.52 (d, 2H). Mass Spectrum (FAB): m/z 531 (M+H, 100%), 287 (55%), 227 (25%), 147 (50%). EXAMPLE 57 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(2-(l-(4-benzyl)- piperidino)ethyl)-3-(SVphenylmoφholine To a solution of 2-(S)-(3,5-bis(trifluoro-methyl)- benzyloxy)-3-(S)-phenylmoφholine (50 mg, 0.12 mmol) and 4-benzyl- l-(2-chloroethyl)piperidine hydrochloride (50 mg, 0.18 mmol) in acetonitrile (0.5 mL) was added diisopropylethylamine (O.065 mL, 0.36 mmol) at room temperature. After 60 hours, TLC (5% MeOH/2% Et3N/93% EtOAc) indicated that the reaction was only partially complete. The reaction was diluted with methylene chloride and washed with water, then brine, dried over sodium sulfate and evaporated. Prep TLC (5% MeOH/2% Et3N/93% EtOAc) afforded 36 mg (50%) of the title compound as an oil. lH-NMR (400 MHz, CDCI3) δ 1.1-1.4 (m, 2 H), 1.4-1.65 (2 m, 4 H), 1.65-2.05 (m, 3 H), 2.05-2.3 (m,. IH), 2.35-2.5 (m and d, J = 7 Hz, 3 H), 2.55 (br t, J = 11 Hz, 1 H), 2.65-2.8 (m, 2 H), 3.09 (d, J = 11 Hz, 1 H), 3.50 (d, J = 2.5 Hz, 1 H), 3.66 (dd, J = 2 and 11 Hz, 1 H), 4.15 (dt, J = 2 and 12 Hz, 1 H), 4.38 and 4.75 (AB q, J = 13 Hz, 2 H), 4.61 (d, J = 2.5 Hz, 1 H), 7.06 (d, J = 7 Hz, 2 H), 7.15 (t, J = 7 Hz, 1 H), 7.2-7.35 (m, 5 H), 7.36 (m, 4 H), 7.75 (s, IH). EXAMPLE 58 (S)-(4-Fluorophenyl)glycine Via Chiral Synthesis: Step A: 3- ( 4-Ruorophenv acetyl-4-(S -benzyl-2-oxazolidinone An oven-dried, 1 L 3-necked flask, equipped with a septum, nitrogen inlet, thermometer, and a magnetic stirring bar, was flushed with nitrogen and charged with a solution of 5.09 g (33.0 mmol) of 4-fluorophenylacetic acid in 100 mL of anhydrous ether. The solution was cooled to -10°C and treated with 5.60 mL (40.0 mmol) of triethylamine followed by 4.30 mL (35.0 mmol) of trimethylacetyl chloride. A white precipitate formed immediately. The resulting mixture was stirred at -10°C for 40 minutes, then cooled to -78°C. An oven-dried, 250 mL round bottom flask, equipped with a septum and a magnetic stirring bar, was flushed with nitrogen and charged with a solution of 5.31 g (30.0 mmol) of 4-(S)-benzyl-2- oxazolidinone in 40 mL of dry THF. The solution was stirred in a dry ice/acetone bath for 10 minutes, then 18.8 mL of 1.6 M n-butyllithium solution in hexanes was slowly added. After 10 minutes, the lithiated oxazolidinone solution was added, via cannula, to the mixture in the 3- necked flask. The cooling bath was removed from the resulting mixture and the temperature was allowed to rise to 0°C. The reaction was quenched with 100 mL of saturated aqueous ammonium chloride solution, transferred to a 1 L flask, and the ether and THF were removed in vacuo. The concentrated mixture was partitioned between 300 mL of methylene chloride and 50 mL of water and the layers were separated. The organic layer was washed with 200 mL of 2 N aqueous hydrochloric acid solution, 300 mL of saturated aqueous sodium bicarbonate solution, dried over magnesium sulfate and concentrated in vacuo. Rash chromatography on 400 g of silica gel using 3:2 v/v hexanes/ether as the eluant afforded 8.95 g of an oil that slowly solidified on-standing. Recrystallization from 10:1 hexanes/ether afforded 7.89 g (83%) of the title compound as a white solid, mp 64- 66°C. Mass Spectrum (FAB): m/Z 314 (M+H, 100%), 177 (M-ArCH2CO+H, 85%). lH-NMR (400 MHz, CDCI3): δ 2.76 (dd, 1 H, J = 13.2, 9.2), 3.26 (dd, J = 13.2, 3.2), 4.16-4.34 (m, 4 H), 4.65-4.70 (m, 1 H), 7.02-7.33 (m, 9 H). Analysis: Calcd for C 18H 16FNO3 : C, 69.00; H, 5.15; N, 4.47; F, 6.06 Found: C, 68.86; H, 5.14; N, 4.48; F, 6.08 Step B: 3-((S)-Azido-(4-fluorophenyl))acetyl-4-(S)-benzyl-2- oxazolidinone An oven-dried, 1 L 3-necked flask, equipped with a septum, nitrogen inlet, thermometer, and a magnetic stirring bar, was flushed with nitrogen and charged with a solution of 58.0 mL of 1 M potassium bis(trimethylsilyl)amide solution in toluene and 85 mL of THF and was cooled to -78°C. An oven-dried, 250 mL round-bottomed flask, equipped with a septum and a magnetic stirring bar, was flushed with nitrogen and charged with a solution of 7.20 g (23.0 mmol) of 3- (4-fluorophenyl)acetyl-4- (S )-benzy 1-2-oxazolidinone (from Example 58, Step A) in 40 mL of THF. The acyl oxazolidinone solution was stirred in a dry ice/acetone bath for 10 minutes, then transferred, via cannula, to the potassium bis(trimethylsilyl)amide solution at such a rate that the internal temperature of the mixture was maintained below -70°C. The acyl oxazolidinone flask was rinsed with 15 mL of THF and the rinse was added, via cannula, to the reaction mixture and the resulting mixture was stirred at -78°C for 30 minutes. An oven- dried, 250 mL round-bottomed flask, equipped with a septum and a magnetic stirring bar, was flushed with nitrogen and charged with a solution of 10.89 g (35.0 mmol) of 2,4,6-triisopropylphenylsulfonyl azide in 40 mL of THF. The azide solution was stirred in a dry ice/acetone bath for 10 minutes, then transferred, via cannula, to the reaction mixture at such a rate that the internal temperature of the mixture was maintained below -70°C. After 2 minutes, the reaction was quenched with 6.0 mL of glacial acetic acid, the cooling bath was removed and the mixture was stirred at room temperature for 18 hours. The quenched reaction mixture was partitioned between 300 mL of ethyl acetate and 300 mL of 50% saturated aqueous sodium bicarbonate solution. The organic layer was separated, dried over magnesium sulfate, and concentrated m vacuo. Rash chromatography on 500 g of silica gel using 2: 1 v/v, then 1 : 1 v/v hexanes/methylene chloride as the eluant afforded 5.45 g (67%) of the title compound as an oil. IR Spectrum (neat, cm-1): 2104, 1781, 1702. lH-NMR (400 MHz, CDCI3): δ 2.86 (dd, 1 H, J = 13.2, 9.6), 3.40 (dd, 1 H, J = 13.2, 3.2), 4.09-4.19 (m, 2 H), 4.62-4.68 (m, 1 H), 6.14 (s, 1 H), 7.07-7.47 (m, 9 H). Analysis: Calcd for C 18H 15FN4O3 : C, 61.01; H, 4.27; N, 15.81; F, 5.36 Found: C, 60.99; H, 4.19; N, 15.80; F, 5.34 Step C: (S)-Azido-(4-fluorophenyDacetic acid A solution of 5.40 g (15.2 mmol) of 3-((S)-azido-(4- fluorophenyl))acetyl-4-(S)-benzyl-2-oxazolidinone (from Example 58, Step B) in 200 mL of 3:1 v/v THF/water was stirred in an ice bath for 10 minutes. 1.28 g (30.4 mmol) of lithium hydroxide monohydrate was added in one portion and the resulting mixture was stirred cold for 30 minutes. The reaction mixture was partitioned between 100 mL of methylene chloride and 100 mL of 25% saturated aqueous sodium bicarbonate solution and the layers were separated. The aqueous layer was washed with 2 x 100 mL of methylene chloride and acidified to. pH 2 with 2 N aqueous hydrochloric acid solution. The resulting mixture was extracted with 2 x 100 mL of ethyl acetate; the extracts were combined, washed with 50 mL of saturated aqueous sodium chloride solution, dried over magnesium sulfate, and concentrated in vacuo to afford 2.30 g (77%) of the title compound as an oil that was used in the following step without further purification. IR Spectrum (neat, cm-1): 2111, 1724. lH-NMR (400 MHz, CDCI3): δ 5.06 (s, 1 H), 7.08-7.45 (m, 4 H), 8.75 (br s, 1 H). Step D: (S)-(4-Fluorophenyl)glycine A mixture of 2.30 g (11.8 mmol) of (S)-azido-(4- fluorophenyl)acetic acid (from Example 58, Step C), 250 mg 10% palladium on carbon catalyst and 160 mL 3:1 v/v water/acetic acid was stirred under an atmosphere of hydrogen for 18 hours. The reaction mixture was filtered through Celite and the flask and filter cake were rinsed well with -1L of 3:1 v/v water/acetic acid. The filtrate was concentrated in vacuo to about 50 mL of volume. 300 mL of toluene was added and the mixture concentrated to afford a solid. The solid was suspended in 1:1 v/v methanol/ether, filtered and dried to afford 1.99 g (100%) of the title compound. lH-NMR (400 MHz, D2θ + NaOD): δ 3.97 (s, 1 H), 6.77 (app t, 2 H, J = 8.8), 7.01 (app t, 2 H, J = 5.6). Via Resolution: Step A': 4-Ruorophenylacetyl chloride A solution of 150 g (0.974 mol) of 4-fluorophenylacetic acid an 1 mL of N,N-dimethylformamide in 500 mL of toluene at 40 °C was treated with 20 mL of thionyl chloride and heated to 40°C. An additional 61.2 mL of thionyl chloride was added dropwise over 1.5 hours. After the addition, the solution was heated at 50 °C for 1 hour, the solvent was removed in vacuo and the residual oil was distilled at reduced pressure (1.5 mmHg) to afford 150.4 g (89.5%) of the title compound, bp = 68-70 C. Step B': Methyl 2-bromo-2-(4-fluoro phenylacetate A mixture of 150.4 g (0.872 mol) of4-fluorophenylacetyl chloride (from Example 58, Step A') and 174.5 g (1.09 mol) of bromine was irradiated at 40-50 °C with a quartz lamp for 5 hours. The reaction mixture was added dropwise to 400 mL of methanol and the solution was stirred for 16 hours. The solvent was removed in vacuo and the residual oil was distilled at reduced pressure (1.5 mmHg) to afford 198.5 g (92%) of the title compound, bp = 106-110 °C. Step C: Methyl (±V(4-fluorophenyDglvcine A solution of 24.7 g (0.1 mol) of methyl 2-bromo-2-(4- fluoro) phenylacetate (from Example 58, Step B') and 2.28 g (0.01 mol) of benzyl triethylammonium chloride in 25 mL of methanol was treated with 6.8 g (0.105 mol) of sodium azide and the resulting mixture was stirred 20 hours at room temperature. The reaction mixture was filtered; the filtrate was diluted with 50 mL of methanol and hydrogenated in the presence of 0.5 g of 10% Pd/C at 50psi for 1 hour. The solution was filtered and the solvent removed in vacuo. The residue was partitioned between 10% aqueous sodium carbonate solution and ethyl acetate. The organic phase was washed with water, saturated aqueous sodium chloride solution, dried over magnesium sulfate and concentrated in vacuo to afford 9.8 g of the title compound as an oil. Step D': Methyl (S " )-(4-fluorophenyD glycinate A solution of 58.4 g of methyl (±)-4-fluorophenylglycinate (from Example 58, Step C) in 110 mL of 7:1 v/v ethanol/water was mixed with a solution of 28.6 g (0.0799 mol) of 0,0'-(+)- dibenzoyltartaric acid ((+)-DBT) (28.6g, 0.0799mol) in 110 mL of 7:1 v/v ethanol: water and the resulting solution was allowed to age at room temperature. Ethyl acetate (220ml) was added after crystallization was complete and the resulting mixture was cooled to -20 °C and filtered to afford 32.4 g of methyl (S)-(4-fluorophenyl) glycinate, (+)-DBT salt (ee = 93.2%).. The mother liquors were concentrated in vacuo and the free base was liberated by partitioning between ethyl acetate and aqueous sodium carbonate solution. A solution of free base, so obtained, in 110 mL of 7: 1 v/v ethanol/water was mixed with a solution of 28.6 g (0.0799 mol) of 0,0'-(-)-dibenzoyltartaric acid ((-)-DBT) (28.6g, 0.0799mol) in 110 mL of 7: 1 v/v ethanol: water and the resulting solution was allowed to age at room temperature. Ethyl acetate (220ml) was added after crystallization was complete and the resulting mixture was cooled to -20 °C and filtered to afford 47.0 g of methyl (R)-(4-fluorophenyl) glycinate, (-)-DBT salt (ee = 75.8%). Recycling of the mother liquors and addition of (+)-DBT gave a second crop of 7.4 g of (S)-(4-fluorophenyl) glycinate, (+)-DBT salt (ee = 96.4%). The two crops of the (S)-amino ester (39.8 g) were combined in 200 mL of 7:1 v/v ethanol/water, heated for 30 minutes and cooled to room temperature. Addition of ethyl acetate, cooling, and filtration afforded 31.7 g of (S)-(4-fluorophenyl) glycinate, (+)-DBT salt (ee>98%). Enatiomeric excesses was determined by chiral HPLC (Crownpak CR(+) 5% MeOH in aqHC104 pH2 1.5ml/min 40°C 200nm). A mixture of 17.5 g of (S)-(4-fluorophenyl) glycinate, (+)- DBT salt and 32 mL of 5.5 N HCl (32ml) was heated at reflux for 1.5 hours. The reaction mixture was concentrated in vacuo and the residue was dissolved in 40 mL of water. The aqueous solution was washed 3 x 30 mL of ethyl acetate and the layers were separated. The pH of the aqueous layer was adjusted to 7 using ammonium hydroxide and the precipitated solid was filtered to afford 7.4 g of the title compound (ee = 98.8%). EXAMPLE 59 3-(S)-(4-Ruorophenyl)-4-benzyl-2-morpholinone Step A: N-Benzyl (S -(4-fluorophenyl)glycine A solution of 1.87 g (11.05 mmol) of (S)-(4-fluoroρhenyl)- glycine (from Example 58) and 1.12 mL (11.1 mmol) of benzaldehyde in 11.1 mL of 1 N aqueous sodium hydroxide solution and 11 mL of methanol at 0°C was treated with 165 mg (4.4 mmol) of sodium borohydride. The cooling bath was removed and the resulting mixture was stirred at room temperature for 30 minutes. Second portions of benzaldehyde (1.12 mL (11.1 mmol)) and sodium borohydride 165 mg (4.4 mmol) were added to the reaction mixture and stirring was continued for 1.5 hours. The reaction mixture was partitioned between 100 mL of ether and 50 mL of water and the layers were separated. The aqueous layer was separated and filtered to remove a small amount of insoluble material. The filtrate was acidified to pH 5 with 2 N aqueous hydrochloric acid solution and the solid that had precipitated was filtered, rinsed well with water, then ether, and dried to afford 1.95 g of the title compound. lH-NMR (400 MHz, D2θ + NaOD): δ 3.33 (AB q, 2 H, J = 8.4), 3.85 (s, 1 H), 6.79-7.16 (m, 4 H). Step B: 3-(SV(4-FluorophenylV4-benzyl-2-moφholinone A mixture of 1.95 g (7.5 mmol) of N-benzyl (S)-(4- fluorophenyl)glycine, 3.90 mL (22.5 mmol) of N,N-diisopropyl- ethylamine, 6.50 mL (75.0 mmol) of 1,2-dibromoethane and 40 mL of N,N-dimethylformamide was stirred at 100°C for 20 hours (dissolution of all solids occurred on warming). The reaction mixture was cooled and concentrated in vacuo. The residue was partitioned between 250 mL of ether and 100 mL of 0.5 N potassium hydrogen sulfate solution and the layers were separated. The organic layer was washed with 100 mL of saturated aqueous sodium bicarbonate solution, 3 x 150 mL of water, dried over magnesium sulfate, and concentrated in vacuo. Rash chromatography on 125 g of silica gel using 3: 1 v/v hexanes/ether as the eluant afforded 1.58 g (74%) of the title compound as an oil. lH-NMR (400 MHz, CDCI3): δ 2.65 (dt, 1 H, J = 3.2, 12.8), 3.00 (dt, 1 H, J = 12.8, 2.8), 3.16 (d, 1 H, J = 13.6), 3.76 (d, 1 H, J = 13.6), 4.24 (s, 1 H), 4.37 (dt, ϊ H, J = 13.2, 3.2), 4.54 (dt, 1 H, J = 2.8, 13.2), 7.07- 7.56 (m, 9 H). EXAMPLE 60 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluorophenyl)-4- benzylmorpholine The title compound was prepared in 72% yield from 3-(S)- (4-fluorophenyl)-4-benzyl-2-morpholinone (from Example 59) using procedures analogous to those in Example 15, Steps A and B. lH-NMR (200 MHz, CDCI3): δ 2.37 (dt, 1 H, J = 3.6, 11.8), 2.83-2.90 (m, 2 H), 3.55-3.63 (m, 2 H), 3.85 (d, 1 H, J = 13.4), 4.14 (dt, 1 H, J = 2.0, 11.8), 4.44 (d, 1 H, J = 13.6), 4.66 (d, 1 H, J = 2.8), 4.79 (d, 1 H, J = 13.4), 7.00-7.70 (12 H). EXAMPLE 61 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluorophenyl) morpholine The title compound was prepared in 70% yield from 2-(S)- (3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluorophenyl)-4- benzylmoφholine (from Example 60) using a procedure analogous to that in Example 15, Step C. Mass Spectrum (FAB): m/Z 424 (M+H, 40%). lH-NMR (400 MHz, CDCI3): δ 1.80 (br s, 1 H), 3.11 (app dd, 1 H, J = 2.2, 12.4), 3.25 (dt, 1 H, J = 3.6, 12.4), 3.65 (app dd, 1 H, J = 3.6, 11.4), 4.05 (dt, 1 H, J = 2.2, 11.8), 4.11 (d, 1 H, J = 2.2), 4.53 (d, 1 H, J = 13.6), 4.71 (d, 1 H, J = 2.2), 4.83 (d, 1 H, J = 13.6), 7.04 (t, 2 H, J 0 = 7.2), 7.33-7.37 (m, 2 H), 7.42 (s, 2 H), 7.72 (s, 1 H). EXAMPLE 62 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluorophenyl)-4-(3- 5 (5-oxo-lH.4H-1.2.4-triazolo methylmorpholine The title compound was prepared in 69% yield from 2-(S)- (3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-(4-fluorophenyl)moφholine (from Example 61) using a procedure analogous to that in Example 18. Mass Spectrum (FAB): m/Z 521 (M+H, 100%). T) lH-NMR (400 MHz, CDCI3): δ 2.55 (dt, 1 H, J = 3.6, 12.0), 2.91 (d, 1 H, J = 11.6), 2.93 (d, 1 H, J = 14.4), 3.57 (d, 1 H, J = 2.8), 3.59 (d, 1 H, J = 14.4), 3.67-3.70 (m, 1 H), 4.18 (dt, 1 H, J = 2.4, 11.6), 4.48 (d, 1 H, J = 13.6), 4.65 (d, 1 H, J = 2.8), 4.84 ( d, 1 H, J = 13.6), 7.07 (t, 2 H, J = 8.4), 7.40 (s, 2 H), 7.45-7.48 (m, 2 H), 7.68 (s, 1 H), 10.04 (br s, 1 5 H), 10.69 (br s, 1 H). Analysis: Calcd for C22H19F7N4O3: C, 50.78; H, 3.68; N, 10.77; F, 25.55 Found: C, 50.89; H, 3.76; N, 10.62; F, 25.56 0 EXAMPLE 63 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-((3-pyridyl)methyl carbonyl)-3-(R)-phenylmorpholine A solution of 55 mg (0.315 mmol) of 4-pyridylacetic acid in 1 mL of CH2CI2, containing 0.079 mL (0.715 mmol) of N- methylmoφholine, 53 mg (0.37 mmol) of HOBt and 73 mg (0.37 mmol) of EDC was stirred for 10 min. A solution of 2-(S)-(3,5-bis(tri- fluoromethyl)benzyloxy)-3-(R)-phenylmoφholine (from Example 33) in 1 mL of CH2CI2 was added. After stirring the mixture for 2 h, it was partitioned between water and CH2CI2. The organic layer was washed with water, brine and dried by filtering through Na2Sθ4. The filtrate was concentrated and the residue was purified by flash chromatography using 70% EtOAc/hexane to furnish 152 mg (100 % yield) of the product. lH-NMR (400 MHz, CDCI3): δ 3.0-3.85 (m, 5H), 3.95 & 4.4 (br s, IH), 4.66 (d, J = 13 Hz, IH), 4.82 (d, J = 13 Hz, IH), 5.0 & 5.9 (br s, IH), 5.23 (s, IH), 7.1-7.65 (m, 7H), 7.8 (m, 3 H), 8.43 (br s, 2H). EXAMPLE 64 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(methoxycarbonylpentyl)- 3-(R)-phenylmorpholine To a solution of 0.259 g (0.64 mmol) of 2-(S)-(3,5- bis(trifluoromethyl)benzyloxy)-3-(R)-phenylmoφholine (from example 33) in 2 mL of DMF were added 0.16 g (0.77 mmol) of methyl 6- bromohexanoate, 0.155 g (1.12 mmol) of K2CO3 and 2 crystals of nBu4NI. The resulting solution was heated in a 60°C bath for 36 h, at which time a tic indicated incomplete reaction. The bath temperature was raised to 100°C. After 3 h the reaction mixture was cooled and diluted with EtOAc. The EtOAc solution was washed with water (2x), brine and dried over Na2Sθ4. The filtrate was concentrated and the residue was chromatographed using 30% EtOAc/hexane to isolate 220 mg (65%) of the product. lH-NMR (400 MHz, CDCI3): δ 1.0-1.4 (m, 4 H), 1.47 (m, J = 8 Hz, 2H), 1.95 (m, IH), 2.2 (t, J = 8 Hz, 2H), 2.35 (m, 2H), 2.9 (d, J = 13 Hz, IH), 3.07 (d, J = 7 Hz, IH), 3.62 (s, 3H), 3.81 (td, J = 8 Hz and 2 Hz, 1 H), 4.04 (dd, J = 10 Hz and 2 Hz, IH), 4.36 (d, J = 7 Hz, IH), 4.4 (d, J = 13 Hz, IH), 4.79 (d, J = 13 Hz, IH), 7.2-7.4 (m, 7H), 7.66 (s, IH). EXAMPLE 65 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(carboxypentyl)-3-(R)- phenylmorpholine A solution of 0.15 g (0.28 mmol) of 2-(S)-(3,5- Bis(trifluoromethyl)benzyloxy)-4-(methoxycarbonylpentyl)-3-(R)- phenylmoφholine (from Example 64) in 3 mL of MeOH was saponified by treating with 0.5 mL of 5 N NaOH for 40 min at 65°C. The solution was cooled, concentrated and the residue was diluted with water. The aqueous solution was adjusted to pH 6 by adding 2 N HCl and it was extracted with EtOAc. The organic layer was washed with brine, dried and concentrated. The residue upon chromatography on a flash column with 50% EtOAc/hexane furnished 0.13g (89%) of the product lH-NMR (400 MHz, CDCI3): δ 1.0-1.5 (m, 4H), 1.5 (m, 2H), 2.2 (m, 2H), 2.35 (m, 2H), 2.9 (d, J = 13 Hz, IH), 3.08 (d, J = 7 Hz, IH), 3.82 (t, J = 8 Hz, IH), 4.09 (d, J = 7 Hz, IH), 4.38 (s, IH), 4.4 (d, J = 13 Hz, IH), 4.79 (d, J = 13 Hz, IH), 7.2-7.4 (m, 7H), 7.66 (s, IH). EXAMPLE 66 2-(S)-(3,5-Bis(trifluoromethyl)benzyloxy)-4-(methylaminocarbonyl- pentyl -6-oxo-hexyl)-3-(R)-phenylmorpholine A solution of 116 mg (0.22 mmol) of 2-(S)-(3,5- Bis(trifluoromethyl)benzyloxy)-4-(carboxypentyl)3-(R)- phenylmoφholine (from Example 65) in 1 mL of CH2CI2 was treated with 40 mg (0.29 mmol) of HOBt, 57 mg (0.29 mmol) of EDC and 0.037 mL of N-methylmorpholine. After 10 min 0.027 mL (0.3 mmol) of aqueous methylamine (40%) was added and the resulting mixture was stirred for 4 h. The reaction mixture was diluted with water and extracted with CH2CI2. The combined CH2CI2 layer was washed with water, brine and dried over Na2S04, and the filtrate was concentrated. Purification of the residue on a flash column with EtOAc furnished 0.10 g of the product. lH-NMR (400 MHz, CDCI3): δ 1.0-1.4 (m, 4 H), 1.47 (m, 2H), 1.95 (m, IH), 2.04 (t, J = 8 Hz, 2H), 2.35 (m, 2H), 2. 74 (d, J = 5 Hz, 3 H), 2.89(d, J =12 Hz, IH) 3.08 (d, J = 7 Hz, IH), 3.81 (t, J = 7 Hz, IH), 4.02 (d, J = 11 Hz, IH), 4.36 (d, J = 7 Hz, IH), 4.39 (d, J = 13 Hz, IH), 4.79 (d, J =13 Hz, IH), 5.03 (br s, IH), 7.2-7.4 (m, 7H), 7.65 (s, IH). EXAMPLE 67 2-(R)-(3,5-Bis(trifluoromethyl)benzoyloxy)-3-(S)-ρhenyl-4-benzyl morpholine A solution of 2.67 g (10.0 mmol) of 3-(S)-phenyl-4-benzyl- 2-moφholinone (from Example 14) in 40 mL of dry THF was cooled to -78°C. The cold solution was treated with 12.5 mL of 1.0 M L- Selectride®, solution in THF, maintaining the internal reaction temperature below -70°C. The resulting solution was stirred cold for 45 minutes and the reaction as charged with 3.60 mL (20.0 mmol) of 3,-5-bis(trifluoro-methyl)benzoyl chloride. The resulting yellow mixture was stirred cold for 30 minutes and the reaction was quenched with 50 mL of saturated aqueous sodium bicarbonate solution. The quenched mixture was partitioned between 300 mL of ether and 50 mL of water and- the layers were separated. The organic layer was dried over magnesium sulfate. The aqueous layer was extracted with 300 mL of ether; the extract was dried and combined with the original organic layer. The combined organics were concentrated in vacuo. Rash chromatography on 150 g of silica gel using 37:3 v/v hexanes/ether as the eluant afforded 4.06 g (80%) of the title compound as a solid. lH NMR (CDCI3, 200 MHz, ppm): δ 2.50 (dt, J= 3.4, 12.0, IH), 2.97 (app d, J= 12.0, IH), 2.99 (d, J= 13.6, IH), 3.72-3.79 (m, IH), 3.82 (d, J= 2.6, IH), 4.00 (d, J= 13.6, IH), 4.20 (dt, J= 2.4, 11.6), 6.22 (d, J= 2.6, IH), 7.22-7.37 (m, 7H), 7.57 (app d, J= 6.8, 2H), 8.07 (s, IH), 8.47 (s, 2H). Analysis Calcd for C26H21F6NO3: C, 61.29; H, 4.16; N, 2.75; F, 22.38. Found: C, 61.18; H, 4.14; N, 2.70; F, 22.13. EXAMPLE 68 2-(R)-(l-(3,5-Bis(trifluoromethyl)phenyl)ethenyloxy)-3-(S)-phenyl-4- benzyl morpholine Step A: Dimethyl titanocene A solution of 2.49 g (10.0 mmol) of titanocene dichloride in 50 mL of ether in the dark at 0°C was treated with 17.5 mL of 1.4 M methyllithium solution in ether maintaining the internal temperature below 5°C. The resulting yellow/orange mixture was stirred at room temperature for 30 minutes and the reaction was quenched by slowly adding 25 g of ice. The quenched reaction mixture was diluted with 50 mL of ether and 25 mL of water and the layers were separated. The organic layer was dried over magnesium sulfate and concentrated in vacuo to afford 2.03 g (98%) of the title compound as a light-sensitive solid. The dimethyl titanocene could be stored as a solution in toluene at 0°C for at least 2 weeks without apparent chemical degradation. lH NMR (CDC13, 200 MHz, ppm): δ -0.15 (s, 6H), 6.06 (s, 10H). Step B: 2-(R)-(l-(3,5-Bis(trifluoromethyl)phenyl)ethenyloxy)-3- (S -phenyl-4-benzyl morpholine A solution of 2.50 g (4.9 mmol) of 2-(R)-(3,5-bis(tri- fluoro-methyl)benzoyloxy)-3-(S)-phenyl-4-benzyl moφholine (from Example 67) and 2.50 g (12.0 mmol) of dimethyl titanocene (from Example 68, Step A) in 35 mL of 1: 1 v/v THF/toluene was stirred in an oil bath at 80°C for 16 hours. The reaction mixture was cooled and concentrated in vacuo. Flash chromatography on 150 g of silica gel using 3:1 v/v hexanes/methylene chloride as the eluant afforded 1.71 g (69%) of the title compound as a solid. Mass Spectrum (FAB): m/Z 508 (M+H, 25%). lH NMR (CDC13, 400 MHz, ppm): δ 2.42 (dt, J= 3.6, 12.0, IH), 2.89 (app d, J= 11.6), 2.92 (d, J= 13.6, IH), 3.61-3.66 (m, IH), 3.73 (d, J= 2.8), IH), 4.00 (d, J= 13.6, IH), 4.09 (dt, J= 2.4, 11.6, IH), 4.75 (d, J= 2.8, IH), 4.79 (d, J= 2.8, IH), 5.36 (d, J= 2.4, IH), 7.23-7.41 (m, 7H), 7.63 (app d, J= 7.2, 2H), 7.79 (s, IH), 7.91 (s, 2H). Analysis Calcd for C27H23F6NO2: C, 63.90; H, 4.57; N, 2.76; F, 22.46. Found: C, 63.71; H, 4.53; N, 2.68; F, 22.66. EXAMPLE 69 2-(R)-(l-(S)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl moφholine and 2-(S)-(l - (R)- ( ,5-B is (trifluoromethyl)phenyl)ethoxy )- 3-(S)-phenyl morpholine A mixture of 1.50 g (2.9 mmol) of 2-(R)-(l-(3,5-bis(tri- fluoromethyl)phenyl)ethenyloxy)-3-(S)-phenyl-4-benzyl moφholine (from Example 68) and 750 mg 10% palladium on carbon catatlyst in 25 mL of 3:2 v/v isopropanol/ethyl acetate was stirred under an atmosphere of hydrogen for 48 hours. The catalyst was filtered onto a pad of Celite; the reaction flask and filter pad were rinsed with 500 mL of ethyl acetate. The filtrate was concentrated in vacuo. Rash chromatography on 60 g of silica gel using 2:1 v/v hexanes/ether, then 2:1 v/v hexanes/ether afforded 106 mg of 2-(R)-(l-(S)-(3,5-bis(tri- fluoromethyl)phenyl)ethoxy)-3-(S)-phenyl moφholine and 899 mg of 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl moφholine, both as oils (84% total yield). For 2-(R)-(l-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl moφholine: Mass Spectrum (CI): m/Z 420 (M+, 20%), 178 (100%). lH NMR (CDC13, 400 MHz, ppm): δ 1.46 (d, J= 6.8), 1.92 (br s, IH), 3.13 (dd, J= 3.0, 12.6, IH), 3.24 (dt, J= 3.6, 12.6, IH), 3.62 (dd, J= 3.6, 11.2), 4.04 (d, J= 2.4, IH), 4.14 (dt, J= 3.0, 11.2, IH), 4.48 (d, J= 2.4, IH), 4.90 (q, J= 6.8, IH), 7.21-7.32 (m, 7H), 7.64 (s, IH). Analysis Calcd for C20H19F6NO2: C, 57.28; H, 4.57; N, 3.34; F, 27.18. Found: C, 57.41; H, 4.61; N, 3.29; F, 27.23. EXAMPLE 70 2-(R)-(l-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4- (3-(5-oxo- 1.2.4-triazolo)methylmorpholine Step A: 2-(R)-(l-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(2-(N-methylcatboxy-acetamidrazono) morpholine A solution of 945 mg (2.3 mmol) of 2-(R)-(l-(R)-(3,5- bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl moφholine (from Example 69), 447 mg (2.7 mmol) of N-methylcarboxy-2-chloro- acetamidrazone (from Example 45, Step A), and 0.78 mL (4.5 mmol) of N,N-diisopropylethylamine in 17 mL of acetonitrile was stirred at room temperature for 20 hours. The reaction was concentrated in vacuo and the residue was partitioned between 50 mL of methylene chloride and 25 mL of water. The organic layer was separated, dried over magnesium sulfate and concentrated in vacuo. Rash chromatography on 50 g of silica gel using 50:1:0.1 methylene chloride/methanol/ammonium hydroxide as the eluant afforded 1.12 g (90%) of the title compound as a foam. Step B: 2-(R)-(l-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3- (SVρhenyl-4-(3-(5-oxo- 1.2.4-triazolo methylmoφholine A solution of 1.01 g (1.8 mmol) of 2-(R)-(l-(R)-(3,5- bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(2-(N-methyl- carboxyacetamidrazono)moφholine (from Example 70, Step A) in 15 mL of xylenes was heated at reflux for 2 hours. The reaction was cooled and concentrated in vacuo. Flash chromatography on 50 g of silica gel using 50:1:0.1 methylene chloride/methanol/ammonium hydroxide as the eluant afforded 781 mg (76%) of the title compound as a solid. Mass Spectrum (FAB) m Z 517 (M+H, 18%), 178 (100%). lH NMR (CDC13, 400 MHz, ppm): δ 1.47 (d, J= 6.8), 2.01-2.05 (m, 2H), 2.55 (dt, J= 3.6, 12.0, IH), 2.91 (d, J= 10.8, IH), 2.95 (d, J= 14.8, IH), 3.49 (d, J= 2.4, IH), 3.65 (d, J= 14.8, IH), 3.69 (d, J= 10.8, IH), 4.29 (dt, J= 2.4, 10.0), 4.38 (d, J= 2.8, IH), 4.88 (q, J= 6.8, IH), 7.14 (s, 2H), 7.33-7.40 (m, 5H), 7.62 (s, IH), 9.91 (br s, IH), 10.16 (br s, IH). Analysis Calcd for C23H22F6N4O3: C, 53.49; H, 4.06; N, 10.85; F, 22.07. Found: C, 53.64; H, 4.33; N, 10.81; F, 22.27. EXAMPLE 71 2-(R)-(l-(S)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4- (3-(5-oxo-1.2.4-triazolo")methylmorpholine The title compound was prepared in 32% yield from 2-(R)- (l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl moφholine (from Example 69) using a procedure analogous to Example 70. Mass Spectrum (FAB): m/Z 517 (M+H, 100%), 259 (50%). lH NMR (CDCI3, 400 MHz, ppm): δ 1.09 (d, J= 6.4, 3H), 2.47-2.53 (m, IH), 2.83 (app d, J= 11.6, IH), 2.95 (d, J= 14.0, IH), 3.51-3.65 (m, 3H), 4.01 (app t, J= 11.6, IH), 4.60 (q, J= 6.4, IH), 4.84 (d, J= 2.4, IH), 7.33-7.51 (m, 5H), 7.74 (s, 2H), 7.76 (s, IH), 9.51 (br s, IH), 10.00 (br s, IH). EXAMPLE 72 2-(R)-(3,5-Bis(trifluoromethyl)benzoyloxy)-3-(S)-(4-fluoro)phenyl-4- benzyl morpholine The title compound was prepared in 83% yield from 3-(R)- (4-fluoro)phenyl-4-benzyl-2-morpholinone (from Example 59) using a procedure analogous to Example 67. Mass Spectrum (FAB): m/Z 528 (M+H, 25%), 270 (100%). iH NMR (CDC13, 400 MHz, ppm): δ 2.50 (dt, J= 3.2, 12.0, IH), 2.96 (app d, J= 12.0, IH), 2.98 (d, J= 13.6, IH), 3.74-3.78 (m, IH), 3.81 (d, J= 2.8, IH), 3.94 (d, J= 13.6, IH), 4.19 (dt, J= 2.0, 12.0), 6.20 (d, J= 2.8, IH), 6.99 (t, J= 8.4, 2H), 7.27-7.38 (m, 5H), 7.52-7.56 (m, 2H), 8.09 (s, IH), 8.46 (s, 2H). EXAMPLE 73 2-(R)-(l-(3,5-Bis(trifluoromethyl)phenyl)ethenyloxy)-3-(S)-(4-fluoro)- phenyl-4-benzyl morpholine The title compound was prepared in 60% yield from 2-(R)- (3,5-bis(trifluoromethyl)benzoyloxy)-3-(S)-(4-fluoro)phenyl-4-benzyl moφholine (Example 72) using a procedure analogous to Example 68. Mass Spectrum (FAB): m Z 526 (M+H, 75%), 270 (100%). lH NMR (CDCI3, 400 MHz, ppm): δ 2.42 (dt, J= 3.6, 12.0), 2.90 (app d, J= 12.0, IH), 2.91 (d, J= 13.6, IH), 3.62-3.66 (m, IH), 3.72 (d, J= 2.6), 3.94 (d, J= 13.6, IH), 4.09 (dt, J= 2.4, 12.0, IH), 4.75 (d, J= 3.2, 1H),.4.82 (d, J= 3.2, IH), 5.32 (d, J= 2.6, IH), 7.09 (t, J= 8.8, 2H), 7.24-7.33 (m, 5H), 7.58-7.62 (m, 2H), 7.80 (s, IH), 7.90 (s, 2H). EXAMPLE 74 2-(R)-(l-(S)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl moφholine and 2-(S)-(l-(R)-(3,5-Bis(trifluoromethyl)- phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl morpholine A mixture of 1.83 g (3.5 mmol) of 2-(R)-(l-(3,5-bis(tri- fluoromethyl)phenyl)ethenyloxy)-3-(S)-(4-fluoro)phenyl-4-benzyl moφholine (from Example 73) and 800 mg 5% rhodium on alumina catalyst in 40 mL of absolute ethanol was stirred under an atmosphere of hydrogen for 24 hours. The catalyst was filtered onto a pad of Celite; the reaction flask and filter cake were rinsed with 200 mL of ethyl acetate. The filtrate was concentrated in vacuo and the residue was pumped under high vacuum ( 1 mmHg, room temperature) to dryness. The residue was redissolved in 40 mL of isopropanol; 800 mg of 10% palladium on carbon catalyst was added and the resulting mixture was stirred under an atmosphere of hydrogen for 24 hours. The catalyst was filtered onto a pad of Celite; the reaction flask and filter cake were rinsed with 200 mL of ethyl acetate. The filtrate was concentrated in vacuo. Flash chromatography on 50 g of silica gel using 2:1 v/v hexanes/ether, then 3:2 v/v ether/hexanes as the eluant afforded 283 mg of 2-(R)-(l-(S)-(3,5-bis(trifluoromethyl)phenyl)- ethoxy)-3-(S)-(4-fluoro)phenyl moφholine and 763 mg of 2-(R)-(l- (R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl moφholine, both as oils (total yield 68%). For 2-(R)-(l-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)ρhenyl moφholine: Mass Spectrum (FAB) m/Z 438 (M+H, 65%), 180 (100%). lH NMR (CDCI3, 400 MHz, ppm): δ 1.47 (d, J= 6.8, 3H), 1.87 (br s, IH), 3.03 (dd, J= 2.8, 12.8), 3.17 (dt, J= 4.0, 12.4, IH), 3.43-3.47 (m, IH), 3.80 (dt, J= 3.2, 11.6), 4.10 (d, J= 2.2, IH), 4.70 (q, J= 6.8, IH), -4.87 (d, J= 2.2, IH), 6.99-7.03 (m, 2H), 7.23-7.27 (m, 2H), 7.63 (s, . 2H), 7.66 (s, IH). For 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- . fluorophenyl moφholine: Mass Spectrum (FAB) m/Z 438 (M+H, 75%), 180 (100%). lH NMR (CDCI3, 400 MHz, ppm): δ 1.16 (d, J= 6.8), 1.80 (br s, IH), 3.13 (dd, J= 3.2, 12.4), 3.23 (dt, J= 3.6, 12.4), 3.63 (dd, J= 2.4, 11.2), 4.01 (d, J= 2.4, IH), 4.13 (dt, J= 3.2, 12.0), 4.42 (d, J= 2.4, IH), 4.19 (q, J= 6.8, IH), 7.04-7.09 (m, 2H), 7.27-7.40 (m, 4H), 7.73 (s, IH). EXAMPLE 75 2-(R)-(l-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)- phenyl-4-(3-(5-oxo- 1.2,4-triazolo methylmorpholine The title compound was prepared in 79% yield from 2-(R)- (l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl moφholine (from Example 74) using a procedure anaolgous to Example 70. Mass Spectrum (FAB): m/Z 535 (M+H, 100%), 277 (60%). lH NMR (CDC13 + CD3OD, 400 MHz, ppm): δ 1.48 (d, J= 6.8, 3H), 2.52 (app t, J= 10.4, IH), 2.85-2.88 (m, 2H), 3.47 (d, J= 2.8, IH), 3.63 (d, J= 14.4, IH), 3.70 (dd, J= 2.0, 11.6, IH), 4.24 (app t, J= 10.8, IH), 4.35 (d, J= 2.8, IH), 4.91 (q, J= 6.8, IH), 7.07 (app t, J= 8.4, 2H), 7.15 (s, 2H), 7.37-7.40 (m, 2H), 7.65 (s, IH). Analysis Calcd for C23H21 F7N4O3 : C, 51.69; H, 3.96; N, 10.48; F, 24.88. Found: C, 51.74; H, 4.04; N, 10.50; F, 24.59. EXAMPLE 76 2-(R)-(l-(S)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)- phenyl-4-(3-(5-oxo- 1.2.4-triazolo)methylmorpholine The title compound was prepared in 60% yield from 2-(R)- (l-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)ρhenyl moφholine (from Example 74) using a procedure anaolgous to Example 70. Mass Spectrum (FAB): m Z 535 (M+H, 50%), 293 (100%). lH NMR (CDCI3 + CD3OD, 400 MHz, ppm): δ 1.11 (d, J= 6.4, 3H), 2.49 (dt, J= 2.4, 11.2), 2.83 (app d, J= 11.2, IH), 2.95 (d, J= 14.4, IH), 2.48-2.58 (m, 3H), 3.99 (app t, J= 9.6, IH), 4.61 (q, J= 6.4, IH), 4.81 (d, J= 2.4, IH), 7.09 (t, J= 8.8, 2H), 7.50-7.53 (m, 2H), 7.75 (app s, 3H), 10.40 (br s, IH), 11.00 (br s, IH). EXAMPLE 77 2-(R)-(l-(R)-(3-(Trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo- 1.2.4-triazolo methylmorpholine Step A: 2-(R)-( 1 -(R)-(3-(Trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl morpholine The title compound was prepared in 25% yield from 3- (S)-phenyl-4-benzyl-2-moφholinone (from Example 14) using procedures anaolgous to Examples 67-69. lH NMR (CDC13, 400 MHz, ppm): δ 1.39 (d, J= 6.6, 3H), 1.93 (br s, IH), 3.10 (dd, J= 3.0, 12.7, IH), 3.20 (dt, J= 3.6, 12.4, IH), 3.58 (ddd, J= 1.1, 3.8, 11.2, IH), 4.00 (d, J= 2.4, IH), 4.12 (dt, J= 3.0, 11.2, IH), 4.44 (d, J= 2.4, IH), 4.79 (q, J= 6.6, IH), 6.72 (d, J=7.7, IH), 7.01 (s, IH), 7.09 (t, J=7.7, IH), 7.18-7.25 (m, 2H), 7.25-7.3 (m, 3H), 7.34 (d, J=7.7, IH). Analysis: Calcd for Cl9Hl9F3Nlθ2: C-65.14 H-5.47 N-4.00 F-16.27 Found: C-64.89 H-5.73 N-3.83 F- 15.95 Step B: 2-(R)-(l-(R)-(3-(Trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-1.2.4-triazolo methylmoφholine The title compound was prepared in 90% yield from 2- (R) : (l-(R)-(3-(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl moφholine (from Example 77, Step A) using a procedure anaolgous to Example 70. lH NMR (CDCI3, 400 MHz, ppm): δ 1.40 (d, J= 6.3, 3H), 2.53 (br t, J=11.2, IH), 2.86 (app d, J= 12.2, IH), 2.94 (d, J= 14.3, IH), 3.44 (br s, IH), 3.63 (br d, J=14, 2H), 4.27 (app t, J= 11.5, IH), 4.34 (d, J=2.1, IH), 4.76 (q, J= 6.7, IH), 6.63 (d, J=7.7, IH), 6.93 (s, IH), 7.06 (t, J= 7.6, IH), 7.25-7.45 (m, 6H), 9.63 (br s, IH), 9.74 (br s, IH). Analysis: Calcd for C22H22F3N4O3 : C-59.06 H-4.96 N-12.52 F-12.74 Found: C-58.84 H-5.17 N-12.37 F-12.50 EXAMPLE 78 2-(R)-(l-(R)-(3-(Fluoro)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1.2.4-triazolo methylmorpholine Step A: 2-(R)-(l-(R)-(3-(Fluoro)-5-(trifluoromethyl)ρhenyl)- ethoxyV3-(S)-phenyl-moφholine The title compound was prepared in 44% yield from 3- (S)-phenyl-4-benzyl-2-moφholinone (from Example 14) using procedures anaolgous to Examples 67-69. lH NMR (CDCI3, 400 MHz, ppm): δ 1.38 (d, J= 6.6, 3H), 1.90 (br s, IH), 3.17 (dd, J= 3.0, 12.7, IH), 3.18 (dt, J= 3.6, 12.7, IH), 3.58 (ddd, J= 1.1, 3.8, 11.2, IH), 4.02 (d, J= 2.3, IH), 4.11 (dt, J= 3.0, 11.2, IH), 4.44 (d, J= 2.3, IH), 4.78 (q, J= 6.6, IH), 6.29 (d, J=9.2, IH), 6.85 (s, IH), 7.03 (d, J=8.4, IH), 7.18-7.26 (m, 2H), 7.26-7.3 (m, 3H). Analysis: Calcd for C19H18F4N1O2: C-61.95 H-4.93 N-3.80 F-20.63 Found: C-61.78 H-5.14 N-3.71 F-20.35 Step B: 2-(R)-(l-(R)-(3-(Fluoro)-5-(trifluoromethyl)phenyl)- ethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl- morpholine The title compound was prepared in 77% yield from 2- (R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)ethoxy)-3-(S)-phenyl moφholine (from Example 78, Step A) using a procedure anaolgous to Example 70. lH NMR (CDCI3, 400 MHz, ppm): δ 1.40 (d, J= 6.3, 3H), 2.54 (br t, J=l l, IH), 2.87 (app d, J= 12, IH), 2.94 (app d, J= 14, IH), 3.47 (br s, IH), 3.63 (br t, J=14, 2H), 4.25 (app t, J= 11, IH), 4.35 (d, J=1.5, IH), 4.75 (q, J= 6.3, IH), 6.62 (d, J=6.7, IH), 6.78 (s, IH), 7.01 (d J= 8.4, IH), 7.24 (d, J=3.9, IH), 7.35 (br s, 4H), 9.61 (br s, IH), 9.89 (br s, IH). Analysis: Calcd for C22H21F4N4O3: C-56.77 H-4.55 N-12.04 F-16.33 Found: C-56.57 H-4.65 N- 11.94 F-16.13 EXAMPLE 79 2-(S)-(3-Fluoro-5-trifluoromethyl)benzoyloxy)-3-(S)-(4-fluoro)phenyl- 4-benzyl moφholine The title compound was prepared in 57% yield from 3-(S)- (4-fluoro)phenyl-4-benzyl-2-morpholinone (from Example 59) using a procedure analogous to Example 67. Mass Spectrum (CI): m/Z 478 (M+H, 100%) lH NMR (CDCI3, 360 MHz, ppm): δ 2.50 (dt, J= 3.3, 12.0, IH), 2.96(d, J= 12.0, IH), 2.98 (d, J= 13.6, IH), 3.75 (dd,J= 1.7, 11.5, IH), 3.80 (d, J= 13.6, IH), 3.75 (dd, J=1.7, 11.5, IH), 3.80 (d, J= 2.5, IH), 3.92 (d, J= 13.6, IH), 4.19 (dt, J= 2.1 , 12.0, IH), 6.20 (d,J= 2.5, IH), 6.99 (t, J= 8.7, 2H), 7.2-7.37 (m, 5H), 7.51-7.55 (m, 3H), 7.89 (d, J= 8.4, IH), 8.09 (s, IH). EXAMPLE 80 2-(S)-(l-(3-Fluoro-5-trifluoromethyl)phenyl)ethenyloxy)-3-(S)-(4- fluoro)-phenyl-4-benzyl morpholine The title compound was prepared in 85% yield from 2-(S)-(3- fluoro-5-trifluoromethyl)benzoyloxy)-3-(S)-(4-fluoro)phenyl-4-benzyl moφholine (from Example 79) using a procedure analogous to Example 68. Mass Spectrum (CI): m Z 476 (M+H, 100%) lH NMR (CDCI3, 360 MHz, ppm): δ 2.42 (dt, J= 3.6, 12.0 Hz, IH), 2.90 (d, J= 12.0, IH), 2.91 (d, J=13.6, IH), 3.60-3.62 (m, IH), 3.72 (d, J= 2.6, IH), 3.92 (d, J= 13.6, IH), 4.09 (dt, J= 2.4, 12.0, IH), 4.67 (d, J= 2.9, IH) 4.76 (d, J= 2.9, IH), 5.28 (d, J= 2.6, IH), 7.07 (t, J=8.7, 2H), 7.2-7.37 (m, 7H), 7.53 (s, IH), 7.57-7.61 (m, 2H). EXAMPLE 81 2-(S)-(l-(S)-(3-Fluoro-5-trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl moφholine and 2-(S)-(l-(R)-(3-Ruoro-5- trifluoromethyPphenylkthoxyV3-(S)-(4-fluoro phenyl moφholine The title compounds were prepared from 2-(S)-(l-(3- fluoro-5-trifluoromethyl)phenyl) ethenyloxy)-3-(S)-(4-fluoro)-phenyl- 4-benzyl moφholine (from Example 80) using a procedure analogus to Example 74, but using 10% palladium on charcoal as the catalyst. For 2-(S)-(l-(S)-(3-Fluoro-5-trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl morpholine: Mass Spectrum (CI): m/Z 388 (M+H, 100%) lH NMR (CDC13, 360 MHz, ppm): δ 1.12 (d, J= 6.5, 1H),1.83 (s, IH), 3.02 (d, J=10.1, IH), 3.16 (dt, J= 3.6,12.5, IH), 3.43 (dd, J= 2.7, 11.4, IH), 3.81 (dt, J= 2.9, 11.7, IH), 4.09 (d, J=2.1, IH), 4.62 (q, J= 6.5, IH), 4.84 (d, J= 2.1, IH), 7.05 (t, J= 8.8, 2H), 7.2 (d, J= 8.8, 2H), 7.32 (s, IH), 7.38 (dd, J= 5.5, 8.5, 2H).. For 2-(S)-(l-(R)-(3-Fluoro-5-trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl moφholine: Mass Spectrum (CI): m/Z 387 (M+, 100%) lH NMR (CDC13, 360 MHz, ppm): δ 1.42 (d, J= 6.6, 3H), 1.91 (s, IH), 3.11 (dd, J= 3.2, 12.4, IH), 3.22 (dt, J= 3.6, 12.4, IH), 3.58-3.62 (m, IH), 4.01 (d, J= 2.3, IH), 4.11 (dt, J= 3.2, 12.0, IH), 4.41 (d, J= 2.3, IH), 4.80 (q, J= 6.6, IH), 6.41 (d, J= 9.2, IH), 6.86 (s, IH), 7.02 (t, J= 8.7, 2H), 7.08 (d, J= 9.2, 2H), 7.21-7.26 (m, 2H). EXAMPLE 82 2-(S)-(l-(R)-(3-Fluoro-5-trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro phenyl-4-(3-(5-oxo-l ,2,4-triazolo)methyl morpholine The title compound was prepared from 2-(S)-(l-(R)-(3-fluoro-5- trifluoromethyl) phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl moφholine (from Example 81) using a procedure analogous to Example 70, mp 209-211 °C. [ lD = +65.1 (c = 1.0, methanol) lH NMR (CDC13, 360 MHz, ppm): δ 1.32 (d, J= 6.4, IH), 2.38 (t, J= 11.9, IH), 2.76 (d, J= 13.9, IH), 2.84 (d, J= 11.5, IH), 3.32 (s, IH), 3.40 (d, J=13.9, IH), 3.49 (s, IH), 3.61 (d, J= 11.2, IH), 4.11 (t, J=11.3, IH), 4.8 (q, J=6.4, IH), 6.57 (d, J= 9.4, IH), 6.94 (s, IH), 7.1 (t, J= 8.7, 2H), 7.39 (d, J= 8.7, 2H), 7.51 (s, 2H), 11.26 (s, IH), 11.38 (s, IH). EXAMPLE 83 2-(S)-(l-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1.3-imidazolo methyl moφholine Step A: N.N-Diacetyl-4-bromomethyl-2-imidazolone The title compound was prepared according to the procedure of Dolan and Dushinsky (Journal of the American Chemical Society. 70, 657 (1948)). Step B: 2-(S)-(l-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl- morpholine A mixture of 1.00 g (2.28 mmol) of 2-(S)-(l-(R)-(3,5- bis(trifluoro-methyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl moφholine (from Example 74), 0.62 g (2.40 mmol) of N,N-diacetyl-4- bromomethyl-2-imidazolone (from Example 83, Step A) and 0.63 g (4.56 mmol) of potassium carbonate in 10 mL of N,N-dimethyl- formamide was stirred at room temperature for 15 minutes. The reaction was diluted with 100 mL of ethyl acetate and washed with water, saturated aqueous sodium chloride solution, dried over magnesium sulfate, and evaporated in vacuo. The resulting oil was dissolved in 10 mL of ethanol; the resulting solution was treated with 1.05 mL of 33% ethanolic methylamine solution and stirred at room temperature for 10 minutes. The reaction mixture was concentrated in vacuo to afford a solid. Recrystallisation from ethyl acetate/methanol afforded 0.63 g of the title compound, mp 192-194 °C. iH NMR (d6-DMSO, 360 MHz, ppm): δ 1- 5 (d, J= 6.5, 3H), 2.25 (dt, J=8.7, IH), 2.60 (d, J= 13.8, IH), 2.89 (d, J=11.6, IH), 3.28-3.36 (m, 2H), 3.62 (d, J=10.2, IH), 4.1 (t, J=10.0, IH), 4.31 (d, J= 2.7, IH), 4.92 (q, J= 6.5, IH), 5.97 (s, IH), 7.06 (t, J= 8.8, 2H), 7.36 (s, 2H), 7.65- 7.85 (m, 2H), 7.84 (s, IH), 9.58 (s, IH), 9.8 (s, IH). EXAMPLE 84 2-(S)-(l-(R)-(3-Fluoro-5-(trifluoromethyl)phenyl)ethoxy-3-(S)-(4- fluoro phenyl-4-(4-(2-oxo-l ,3-imidazolo ' .methyl moφholine The title compound was prepared from 2-(S)-(l-(R)-(3-fluoro-5- trifluoromethyl) phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl moφholine (from Example 82) using a procedure analogous to Example 83, mp 209-210 °C. [α]D = +92.8 (c = 1.0 , methanol). lH NMR (d6-DMSO, 360 MHz, ppm) δ 1.31 (d, J= 6.5, 3H), 2.24 (dt, J= 3.0, 11.9, IH), 2.6 (d, J= 13.9, IH); 3.61 (d, J= 11.2, IH), 4.1 (t, J= 11.0, IH), 4.29 (d, J= 2.3, IH), 4.8 (q, J= 6.5, IH), 6.00 (s, IH), 6.55 . (d, J= 9.3, IH), 6.94 (s, IH), 7.11 (t, J= 8.7, 2H), 7.39 (d, J= 8.4, IH), ' 7.51 (s, 2H), 9.59 (s, IH), 9.84 (s, IH). EXAMPLE 85 2-(S)-(l-(S)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(R)-(4- fluorophenyl)-4-(3-(5-oxo-lH.4H-1.2.4-triazolo)methylmoφholine The title compound was prepared from (R)-(4- fluoro)phenylglycine using procedures anlogous to Example 59, 67, 68, 69 and 70. [αlD = -67.7 (c = 0.7, MeOH, 20 °C) EXAMPLE 86 The following compounds are prepared from 3-(S)-phenyl-4- benzyl-2-moφholinone (from Example 14) or 3-(S)-(4-fluoro)phenyl- 4-benzyl-2-moφholinone (from Example 59) using procedures analogous to Examples 15, 67 - 69 and 74. The hydrogenation of the 1- (substituted-aryl)ethenyloxy intermediates may be done with 10% palladium on carbon (Example 70) or 5% rhodium on alumina catalyst (Example 74) to give rapid reduction of the enol ether. Removal of the 4-benzyl substituent may be done catalytically under extended hydrogenation with 10% palladium on carbon or 5% rhodium on alumina catalyst or (when dehalogenation or cleavage of the ether might occur) in a second step with 1-chloroethyl chloroformate as in Example 44, Step C. 1) 2-(R)-(l-(R)-(3-(Chloro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-moφholine; 2) 2-(R)-(l-(R)-(3,5-(Dimethyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 3) 2-(R)-(l-(R)-(3-(Fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 4) . 2-(R)-(l-(R)-(3-(Chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 5) 2-(R)-(l-(R)-(3-(Bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 6) 2-(R)-(l-(R)-(3-(Isopropoxy)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 7) 2-(R)-(l-(R)-(3-(Isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-moφholine; 8) 2-(R)-(l-(R)-(3-(Chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl -moφholine; 9) 2-(R)-(l-(R)-(3-(Fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- pheny 1-moφholine ; 10) 2-(R)-(l-(R)-(3-(t-Butyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 11) 2-(R)-(l-(R)-(3-(t-Butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 12 2-(R)-(l-(R)-(3-(t-Butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-morpholine; 13 2-(R)-(l-(R)-(3,5-(Dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-moφholine 14 2-(R)-(l-(R)-(3,5-(Dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 15 2-(R)-(l-(R)-(3,5-Bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-moφholine; 16 2-(R)-(l-(R)-(3,5-Bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-phenyl-morpholine; 17 2-(R)-(l-(R)-(3,5-(Dichloro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 18 2-(R)-(l-(R)-(3,5-(Difluoro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 19 2-(R)-(l-(R)-(l-(Naphthyl)ethoxy)-3-(S)-phenyl-mθφholine; 20 2-(R)-(l-(R)-(l-(4-(Fluoro)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 21 2-(R)-(l-(R)-(l-(3-(Fluoro)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 22 2-(R)-(l-(R)-(l-(3-(Chloro)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 23 2-(R)-(l-(R)-(l-(3-(Methyl)naphthyl))ethoxy)-3-(S)-phenyl- moφholine; 24 2-(R)-(l-(R)-(l-(3-(Trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-moφholine ; 25 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl- moφholine; 26 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-morpholine ; 27 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- pheny 1-moφholine ; 28 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-morpholine; 29 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl- moφholine; 30 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-morpholine; 31 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-moφholine; 32 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-morpholine ; 33 2-(S)-(3-Methyl)benzyloxy-3-(S)-phenyl-moφholine; 34 2-(S)-(3-Methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 35 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-phenyl-moφholine; 36 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 37 2-(S)-(3-Bromo)benzyloxy-3-(S)-phenyl-moφholine; 38 2-(S)-(3-Bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 39 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-phenyl-moφholine; 40 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 41 2-(S)-(3-Chloro)benzyloxy-3-(S)-phenyl-moφholine; 42 2-(S)-(3-Chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; . 43 2-(R)-(l-(R)-(3-Chloio)phenylethoxy)-3-(S)-phenyl-moφholine; 44 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 45 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-phenyl-moφholine; 46 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl- moφholine; 47 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-phenyl-moφholine; 48 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-moφholine; 49 2-(R)-(l-(R)-(3-(thiomethyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 50 2-(R)-(l-(R)-(3-(thiomethyl)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-morpholine; 51 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-phenyl-moφholine; 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 2-(R)-(l-(R)-(3-(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-morpholine; 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)ρhenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-morpholine; 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)pheny 1-moφholine ; 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-morpholine; 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 2-(R)-(l-(R)-(3-(t-butyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- ' moφholine; 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)pheny 1-morpholine; 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-morpholine; 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morρholine ; 69 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-morpholine; 70 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-moφholine; 71 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4-fluoro)- phenyl-moφholine ; 72 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)- phenyl-moφholine; 73 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 74 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)pheny 1-morpholine ; 75 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 76 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 77 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 78 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 79 2-(R)-(l-(R)-(3-(thiomethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 80 2-(R)-<l-(R)-(3-(thiomethyl)-5-(trifluoromethyl)ρhenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-morpholine; 81 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-moφholine; 82 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine ; 83 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-moφholine; 84 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-moφholine; 85 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-moφholine; 86 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 87) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-moφholine; 88) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 89) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-morpholine ; 90) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)pheny 1-morpholine ; 91) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-morpholine; 92) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-moφholine ; 93) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxypheny 1-moφholine ; 94) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-moφholine. EXAMPLE 87 The following compounds are prepared from the corresponding 2-(S)-(substituted-benzyloxy)-3-(S)-aryl moφholines or 2-(R)-(l-(R)- (substituted-aryl)ethoxy)-3-(S)-aryl moφholines (from Example 86) using procedures analogous to Examples 17, 18, 36, 38, 83 or, in the case of the 4-(5-tetrazolyl)methyl-substituted moφholines, by alkylation of the moφholine (from Example 86) with chloroacetonitrile in the presence of a tertiary amine base in acetonitrile, followed by formation of the final product by reacting the resulting nitrile with either sodium azide or trimethylsilylazide in an appropriate solvent. 1) 2-(R)-(l-(R)-(3-(Chloro)-5-(trifluoromethylphenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl-moφholine; 2) 2-(R)-(l-(R)-(3,5-(Dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo-lH,4H-l,2,4-triazolo)methyl-morpholine; 3) • 2-(R)-(l-(R)-(3-(Fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(5-oxo- 1H,4H- 1H,4H- 1 ,2,4-triazolo)methyl-moφholine; 4) 2-(R)-(l-(R)-(3-(Chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 5) 2-(R)-(l-(R)-(3-(Bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 6) 2-(R)-(l-(R)-(3-(Isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 7) 2-(R)-(l-(R)-(3-(Isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 8) 2-(R)-(l-(R)-(3-(Chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-moφholine; 9) 2-(R)-(l-(R)-(3-(Fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-moφholine; 10) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-4-(3-(- 1 ,2,4-triazolo)methyl-moφholine; 11) 2-(R)-(l-(R)-(3-(t-Butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 12) 2-(R)-(l-(R)-(3-(t-Butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-moφholine; 13) 2-(R)-(l-(R)-(3,5-(Dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 14) 2-(R)-(l-(R)-(3,5-(Dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-moφholine; 15) 2-(R)-(l-(R)-(3,5-Bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 16) 2-(R)-(l-(R)-(3,5-Bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- moφholine; 17) 2-(R)-(l-(R)-(3,5-(Dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-morpholine; 18) 2-(R)-(l-(R)-(3,5-(Difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-moφholine; 2-(R)-( 1 -(R)-( 1 -(Naphthy l)ethoxy )-3-(S)-phenyl-4-(3-(5-oxo- lH,4H-l,2,4-triazolo)methyl-morpholine; 2-(R)-(l-(R)-(l-(4-(Fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl-moφholine; 2-(R)-(l-(R)-(l-(3-(Fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-moφholine; 2-(R)-(l-(R)-(l-(3-(Chloro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-morpholine; 2-(R)-(l-(R)-(l-(3-(Methyl)napnthyl))ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-moφholine; 2-(R)-(l-(R)-(l-(3-(Trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl-moφholine; 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl-moφholine; 2-(S) (2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl-morpholine; 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-morpholine; 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4- triazolo)methyl-morpholine; 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H- l,2,4-triazolo)methyl- moφholine; 2-(R)-( 1 -(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)ρhenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- (2-oxo-l,3-imidazolo)methyl-morpholine; 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-morpholine; 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- imidazolo)methy 1-morpholine ; 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl-morpholine; 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- imidazolo)methy 1-moφholine ; 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-morpholine; 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-imidazolo)methyl-moφholine; 2-(R)-( 1 -(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-imidazolo)methyl-mθφholine; 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(5- tetrazolo)methyl-morpholine ; 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(5-tetrazolo)methyl-moφholine; 2-(R)-( 1 -(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- oxo-5H-pyrrol-4-yl)methyl-morpholine; 2-(S)-(2-Fluoro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 2-(R)-( 1 -(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-morpholine; 2-(R)-( 1 -(R)-(2-Fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- (1,2,4- triazolo)methyl-morpholine; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-morpholine; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- moφholine; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl-moφholine ; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-imidazolo)methyl-morpholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 2-(R)-( 1 -(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-imidazolo)methyl-moφholine; 2-(R)-( 1 -(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(5- tetrazolo)methy 1-morpholine ; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(5-tetrazolo)methyl-moφholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4- (5 -tetrazolo)methyl-moφholine ; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- oxo-5H-pyrrol-4-yl)methyl-moφholine; 2-(S)-(2-Chloro-5-trifluoromethyl)benzyloxy-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4- (2-oxo-5 H-pyrrol-4-yl)methy 1-moφholine ; 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 2-(S)-(3-Methyl)benzyloxy-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methy 1-morpholine ; 2-(S)-(3-Methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4- triazolo)methyl-morpholine ; 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-morpholine; 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl-morpholine; 85 2-(S)-(3-Methyl)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo-lH,4H- l,2,4-triazolo)methy 1-morpholine; 86 2-(S)-(3-Methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-morpholine; 87 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-morpholine; 88 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-moφholine; 89 2-(S)-(3-Methyl)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo-l,3- imidazolo)methyl-moφholine; 90 2-(S)-(3-Methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- l,3-imidazolo)methyl-morpholine; 91 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- l,3-imidazolo)methyl-morpholine; 92 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 93 2-(S)-(3-Methyl)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 94 2-(S)-(3-Methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-morpholine; 95 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methy 1-morpholine; 96 2-(R)- l-(R)-(3-Methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-moφholine; 97 2-(S)-(3-Methyl)benzyloxy-3-(S)-ρhenyl-4-(4-imidazolo)methyl- moφholine; 98 2-(S)-(3-Methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-morpholine; 99 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-moφholine; 100) 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 101) 2-(S)-(3-Methyl)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholine; 102) 2-(S)-(3-Methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-moφholine; 103) 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methy 1-moφholine ; 104) 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methy 1-morpholine ; 105) 2-(S)-(3-Methyl)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- yl)methyl-moφholine ; 106) 2-(S)-(3-Methyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 107) 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methy 1-morpholine; 108) 2-(R)-(l-(R)-(3-Methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 109) 2-(S)-(3-Bromo)benzyloxy-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine ; 110) 2-(S)-(3-Bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-( 1,2,4- triazolo)methy 1-moφholine ; 11 l 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine ; 112) 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl-morpholine; 113) 2-(S)-(3-Bromo)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo-lH,4H- l,2,4-triazolo)methyl-moφholine; 114) 2-(S)-(3-Bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- lH,4H-l,2,4-triazolo)methyl-moφholine; 115) 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- lH,4H-l,2,4-triazolo)methyl-moφholine; 116) 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-morpholine; 117) 2-(S)-(3-Bromo)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo-l,3- imidazolo)methyl-morpholine; 118) 2-(S)-(3-Bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- l,3-imidazolo)methyl-morpholine; 119 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- l,3-imidazolo)methyl-morpholine; 120 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo-l,3-imidazolo)methyl-morpholine; 121 2-(S)-(3-Bromo)benzyloxy-3-(S)-phenyl-4-(2-imidazolo)methyl- moφholine; 122 2-(S)-(3-Bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methy 1-moφholine ; 123 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-morpholine; 124 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methy 1-moφholine ; 125 2-(S)-(3-Bromo)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 126 2-(S)-(3-Bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine; 127 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-morpholine; 128 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methy 1-moφholine ; 129 2-(S)-(3-Bromo)benzyloxy-3-(S)-ρhenyl-4-(5-tetrazolo)methyl- moφholine; 130 2-(S)-(3-Bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-morpholine; 131 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methy 1-moφholine ; 132 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-morpholine; 133 2-(S)-(3-Bromo)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- yl)methy 1-moφholine ; 134 2-(S)-(3-Bromo)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methy 1-morpholine ; 135 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-morpholine; 136 2-(R)-(l-(R)-(3-Bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 137 2-(S)-(3-Chloro)benzyloxy-3-(S)-phenyl-4-(3-( 1,2,4- triazolo)methyl-morpholine ; 138 2-(S)-(3-Chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-( 1,2,4- triazolo)methyl-morpholine; 139 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-morpholine; 140 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl-moφholine; 141 2-(S)-(3-Chloro)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo-lH,4H- l,2,4-triazolo)methyl-moφholine; 142 2-(S)-(3-Chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methy 1-moφholine ; 143 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- lH,4H-l,2,4-triazolo)methyl-moφholine; 144 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 145 2-(S)-(3-Chloro)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo- 1,3- imidazolo)methyl-morpholine; 146 2-(S)-(3-Chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- l,3-imidazolo)methyl-moφholine; 147 2-(R)->(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-morpholine ; 148 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 149 2-(S)-(3-Chloro)benzyloxy-3-(S)-ρhenyl-4-(2-imidazolo)methyl- moφholine; 150 2-(S)-(3-Chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methyl-morpholine; 151 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-morpholine; 152 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methy 1-moφholine ; 153 2-(S)-(3-Chloro)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 154 2-(S)-(3-Chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine ; 155 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-morpholine ; 156 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-morpholine; 157 2-(S)-(3-Chloro)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholine; 158 2-(S)-(3-Chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methy 1-moφholine ; 159 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methy 1-moφholine ; 160 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-morpholine; 161 2-(S)-(3rChloro)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- yl)methyl-moφholine ; 162 2-(S)-(3-Chloro)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-moφholine; 163 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-morpholine; 164 2-(R)-(l-(R)-(3-Chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 165 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methylmorpholine; 166 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3- (l,2,4-triazolo)methyl-morpholine; 167 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (3-(l,2,4-triazolo)methyl-morpholine; 168 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 169 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo- lH,4H-l,2,4-triazolo)methyl-moφholine; 170 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-morpholine; 171 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 172 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 173 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo- l,3-imidazolo)methyl-morpholine; 174 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- (2-oxo- l,3-imidazolo)methyl-morpholine; 175 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 176 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 177 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2- imidazolo)methyl-morpholine; 178 2-(S)-(3-Trifluoromethy])benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methy 1-morpholine ; 179 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (2-imidazolo)methyl-morpholine ; 180 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl-moφholine; 181 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(4- imidazolo)methyl-morpholine; 182 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methy 1-morpholine ; 183 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (4-imidazolo)methy 1-moφholine ; 184 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-moφholine; 185 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(5- tetrazolo)methyl-morpholine ; 186) 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methyl-morpholine; 187) 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (5-tetrazolo)methyl-moφholine; 188) 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 189) 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-morpholine; 190) 2-(S)-(3-Trifluoromethyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- oxo-5H-pyrrol-4-yl)methyl-moφholine; 191) 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 192) 2-(R)-(l-(R)-(3-Trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-ρyrrol-4-yl)methyl-moφholine; 193) 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine ; 194) 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; , 195) 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl-moφholine; 196) 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl-moφholine; 197) 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-phenyl-4-(3-(5-oxo- 1,2,4- triazolo)methyl-morpholine ; 198) 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- l,2,4-triazolo)methyl-morpholine; 199) 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- l,2,4-triazolo)methyl-moφholine; 200) 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 201) 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-phenyl-4-(4-(2-oxo-l,3- imidazolo)methy 1-moφholine ; 202) 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- l,3-imidazolo)methyl-morpholine; 203 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- l,3-imidazolo)methyl-morpholine; 204 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 205 2-(S)-(3-t-Butyl)benzyloxy-3-(S)~phenyl-4-(2-imidazolo)methyl- moφholine; 206 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2- imidazolo)methy 1-morpholine ; 207 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-morpholine; 208 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-morpholine; 209 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-phenyl-4-(4-imidazolo)methyl- moφholine; 210 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(4- imidazolo)methyl-moφholine ; 211 2-(R) (l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-morpholine; 212 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-moφholine; 213 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-phenyl-4-(5-tetrazolo)methyl- moφholirie; 214 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(5- tetrazolo)methy 1-morpholine ; 215 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methy 1-morpholine ; 216 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methy 1-morpholine; 217 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-phenyl-4-(2-oxo-5H-pyrrol-4- yl)methy 1-moφholine ; 218 2-(S)-(3-t-Butyl)benzyloxy-3-(S)-(4-fluoro)phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-morpholine; 219 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-morpholine; 220) 2-(R)-(l-(R)-(3-t-Butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 221) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 222) 2-(R)-( 1 -(R)-(3-(thiomethylphenyl)ethoxy )-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl-morpholine; 223) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl-morpholine; 224) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo- 1 ,2,4-triazolo)methyl-moφholine; 225) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 226) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 227) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-lH,4H-l,2,4- triazolo)methy 1-morpholine ; 228) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-phenyl-4-(3-(l,2,4-triazolo)- methy 1-moφholine ; 229) 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3-dihydro- benzofuran-7-yl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-l,3- imidazolo)methyl-morpholine; 230) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-moφholine; 231) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl-morpholine; 232) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methy 1-moφholine ; 233) 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- moφholine; 234) 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 235) 2-(R)-(l-(R)-(3-(fluoro)-5-(tτifluoromethyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 236) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 237) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 238) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 239) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- moφholine; 240) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 241) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 242) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 243) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 244) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 245) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)ρhenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 246) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 247) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 248) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 249) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 250) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 251) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 252) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 253) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl-moφholine; 254) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)ρhenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl- moφholine; 255) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 256) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl- moφholine; 257) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl- moφholine; 258) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 259) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 260) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 261) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 262) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 263) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 264) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 265) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl-moφholine; 266) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl- moφholine; 267) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 268) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl- moφholine; 269) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- moφholine; 270) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 271) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl-mθφholine; 272) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- moφholine; 273) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 274) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4- (4- (2-oxo- 1 , 3 -imidazolo)methy 1-moφholine ; 275) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl- moφholine; 276) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 277) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl- moφholine; 278) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 279) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 280) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 0 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl- moφholine; 281) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 5 282) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 283) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 284) 2-(R)-(l-(R)-(3,5-(difluoiO)phenyl)ethoxy)-3-(S)-(4- ° fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- moφholine; 285) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 286) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- 5 fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 287) 2-(R)-( 1 -(R)-( 1 -(naphthyl)ethoxy )-3-(S)-(4-fluoro)phenyl-4-(3- (5-oxo-lH,4H-l,2,4-triazolo)methyl-morpholine; 288) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3- (l,2,4-triazolo)methyl-morpholine; 0 289) 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methy 1-moφholine; 290) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 291) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 292) 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 293) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 294) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)pheny l-4-(3 - ( 1 ,2 ,4- tri azolo)methy 1-moφholine ; 295) 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 296) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 297) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 298) 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 299) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- moφholine; 300) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 301) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl-moφholine; 302) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- morpholine; 303) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 304) 2-(R)-(l-(R)-(l-(3-(trifluoromethyl)naphthyl))ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 305 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- moφholine; 306 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 307 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 308 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl- moφholine; 309 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 310 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl- moφholine; 311 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5- oxo- 1 H,4H- 1 ,2,4-triazolo)methyl-moφholine; 312 2-(R)-(l-(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3- (l,2,4-triazolo)methyl-morpholine; 313 2-(R)-( 1 -(R)-(2,2-(dimethyl)-5-(thiomethyl)-2,3- dihydrobenzofuran-7-yl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl-morpholine; 314 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)ρhenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- moφholine; 315 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 316 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)ρhenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 317 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-lH,4H- l,2,4-triazolo)methyl-morpholine; 318) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(3-( 1,2,4- triazolo)methy 1-morpholine ; 319) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-l,3- imidazolo)methyl-morpholine; 320) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5- oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 321) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4- triazolo)methy 1-morpholine ; 322) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2- oxo- 1 ,3-imidazolo)methyl-morpholine; 323) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 324) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-( 1,2,4- triazolo)methy 1-morpholine ; 325) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo- 1 ,3-imidazolo)methyl-moφholine; 326) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 327) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-tπazolo)methyl-morpholine; 328) 2-(R)-(l-(R)-(3-(fluoiO)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl-morpholine; 329) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo- 1 H,4H- 1 ,2,4-triazolo)methyl-moφholine ; 330) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-( 1,2,4- triazolo)methyl-morpholine ; 331) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl-morpholine; 332) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H-l,2,4-triazolo)methyl-morpholine; 332) 2-(R)-(l-(R)-(4-(fluoiO)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl-morpholine; 333) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo-l,3-imidazolo)methyl-morpholine; 334) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- moφholine; 335) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 336) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 337) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(3-(5-oxo- lH,4H-l,2,4-triazolo)methyl- moφholine; 338) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 339) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 340) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- moφholine; - 341) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 342) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 343) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(3-(5-oxo- lH,4H-l ,2,4-triazolo)methyl- moφholine; 344) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(3-(l,2,4-triazolo)methyl-moφholine; 345) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 346) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- moφholine; 347) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-4-(3-( 1 ,2,4-triazolo)methyl-moφholine; 348) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl- moφholine; 349) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(3-(5-oxo-lH,4H- l,2,4-triazolo)methyl-moφholine; 350) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(3-(l ,2,4-triazolo)methyl-moφholine; 351) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 352) 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(3-(- 1 ,2,4-triazolo)methyl-moφholine; 353) 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 354) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(3-(-l,2,4-triazolo)methyl-morpholine; 355) 2-(R)-(l-(RJ-(3-(chloro)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 356) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(- l,2,4-triazolό)methyl-morpholine; 357) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(4- (2-oxo-l,3-imidazolo)methyl-morpholine; 358) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(-l,2,4-triazolo)methyl-morpholine; 359) 2-(R)-(l-(R)-(3-(fluoiO)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methyl-morpholine; 360) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(- 1 ,2,4-triazolo)methyl-morpholine; 361) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methyl-morpholine; 362) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(-l,2,4-triazolo)methyl-morpholine; 363) 2-(R)-(l-(R)-(3-(biOmo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methyl-morpholine; 364 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(- l,2,4-triazolo)methyl-morpholine; 365 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl-moφholine; 366 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(- 1 ,2,4-triazolo)methyl-moφholine; 367 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 368 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(- 1 ,2,4-triazolo)methyl-moφholine; 369 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 370 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(- 1 ,2,4-triazolo)methyl-morpholine; 371 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S>- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 372 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(- 1 ,2,4-triazolo)methyl-morpholine; • 373 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methyl-morpholine; 374 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(- 1 ,2,4-triazolo)methyl-morpholine; 375 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 376 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(- 1 ,2,4-triazolo)methyl-morpholine; 377 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-morpholine; 378 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(- 1 ,2,4-triazolo)methyl-morpholine; 379 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-morpholine; 380 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(- 1 ,2,4-triazolo)methyl-moφholine; 381 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 382 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-ρhenyl-4-(3-(- 1 ,2,4-triazolo)methyl-moφholine; 383 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl-moφholine; 384 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(- l,2,4-triazolo)methyl-morpholine; 385 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl-morpholine; 386 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(- 1 ,2,4-triazolo)methy 1-morpholine; 387 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl-morpholine; 388 2-(R)-(l-(R)-(l-(naphthyl)ethoxy)-3-(S)-phenyl-4-(3-(-l,2,4- triazolo)methy 1-morpholine; 389 2-(R)-( 1 -(R)-( 1 -(naphthyl)ethoxy )-3-(S)-phenyl-4-(4-(2-oxo- 1 ,3- imidazolo)methy 1-morpholine ; 390 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (- 1 ,2,4-triazolo)methyl-morpholine; 391 2-(R)-(l-(R)-(l-(4-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl-morpholine; 392 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (- 1 ,2,4-triazolo)methy 1-morpholine; 393 2-(R)-(l-(R)-(l-(3-(fluoro)naphthyl))ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl-morpholine; 394 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (- 1 ,2,4-triazolo)methyl-morpholine; 395 2-(R)-(l-(R)-(l-(3-(chloro)naphthyl))ethoxy)-3-(S)-phenyl-4-(4- (2-oxo-l,3-imidazolo)methyl-morpholine; 396 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl-4-(3- (- 1 ,2,4-triazolo)methyl-morpholine; and 397 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl-morpholine. EXAMPLE 88 2-(R)-(2,5-Bis(trifluoromethyl)benzoyloxy)-3-(S)-(4-fluorophenyl)-4- benzyl-moφholine The title compound was prepared from 3-(S)-(4- fluorophenyl)-4-benzyl-2-morpholinone (from Example 59) using a procedure analogous to Example 67. Mass Spectrum (CI): m Z 528 (M+H) lH NMR (CDCI3, 360 MHz, ppm): δ 2.46 (dt, IH), 2.90 (dd, 2H), 3.76 (dd, J= 11.6, 2.0, IH), 3.88 (d, J= 13.6, IH), 4.18 (t, IH), 6.20 (d, J=2.8, IH), 7.04 (d, J= 8.4, 2H), 7.24-7.32 (m, 5H), 7.50, (m, 2H), 7.60 (s, IH), 7.88 (dd, 2H). EXAMPLE 89 2-(R)-(l-(2,5-Bis(trifluoromethyl)phenyl)ethenyloxy)-3-(S)-(4- fluorophenyl)-4-benzyl-morpholine The title compound was prepared from 2-(R)-(2,5- bis(trifluoromethyl) benzoyloxy)-3-(S)-(4-fluorophenyl)-4-benzyl- moφholine (from Example 88) using a procedure analogous to Example 68. lH NMR (CDCI3, 250 MHz, ppm): δ 2.30 (dt, J= 3.5, 11.9, IH), 2.74 (app d, J= 9.4, IH), 2.82 (d, J=13.5, IH), 3.55-3.60 (m, 2H), 3.72 (d, J= 13.5, IH), 4.10 (dt, J= 2.4, 11.7, IH), 4.22 (d, J= 2.7, IH), 4.67 (d, J=2.8, IH), 5.18 (d, J=2.8, IH), 6.90 (t, J=8.7, 2H), 7.08 (s, IH), 7.13- 7.23 (m, 5H), 7.36 (dd, J= 5.6, 8.7, 2H). 7.62 (d, J= 8.4, IH), 7.72 (d, J= 8.4. IH). EXAMPLE 90 2-(R)-(l-(R)-(2,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyP-morpholine The title compound was prepared from 2-(R)-(l-(2,5- bis(trifluoromethyl) phenyl)ethenyloxy)-3-(S)-(4-fluorophenyl)-4- benzyl-moφholine (from Example 89) using a procedure analogous to Example 74. Mass Spectrum (CI): m/Z 438 (M+H) lH NMR Spectrum (HCl salt, d6-DMSO, 360 MHz, ppm): δ 1.47 (d, J= 8.7, 3H), 3.88 (d, J= 11.8, IH), 4.20 (dt, J= 3.7, 11.8, IH), 4.50 (s, IH), 4.58 (s, IH), 5.17 (m, IH), 7.04 (s, IH), 7.23 (t, J= 8.8, 2H), 7.55 (m, 2H), 7.77 (d, J= 8.1, IH), 7.88 (d, J= 8.3, IH), 10.1 (br s, IH). 10 EXAMPLE 91 2-(R)-(l-(R)-(2,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl -4-(3-(5-oxo- 1 H.4H- 1.2.4-triazolo)methyl-moφholine The title compound was prepared from 2-(R)-(l-(R)-(2,5- 15 bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)-moφholine (from Example 90) using a procedure analogous to Example 70, mp 162-168 °C. lH NMR (d6-DMSO, 360 MHz, ppm) δ 1.37 (d, J= 6.4, 3H), 2.40 (dt, J= 3.3, 11.9, IH), 2.77 (d, J= 14.0, IH), 2.86 (d, J= 11.5, IH), 3.37 (d, • 20 J= 14.4, IH), 3.48 ( d, J= 2.7, IH), 3.64 (d, J= 11.0, IH), 4.11 (t, J= 9.8, IH), 4.18 ( d, J= 2.8, IH), 5.16 (q, J= 6.2, IH), 6.90 (s, IH), 7.08 ( t, J= 8.8, 2H), 7.50 (br t, IH), 7.74 (d, J= 8.3, IH), 7.85 (d, J= 8.3, IH), 11.25 s, IH), 11.35 (s, IH). 25 EXAMPLE 92 2-(R)-(l-(R)-(2,5-Bis(trifluoiOmethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl -4-(3-( 1 ,2.4-triazolo methyl-morpholine The title compound was prepared from 2-(R)-(l-(R)-(2,5- 30 bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)-moφholine (from Example 90) using a procedure analogous to Example 17, mp 98- 100 °C. Mass Spectrum (CI): m/Z 519 (M+H) lH NMR (d6-DMSO, 360 MHz, ppm): δ 1.36 (d, J= 6.4, 3H), 2.46 (dt, J= 3.26, 11.9, IH), 2.89 (d, J= 11.0, IH), 3.16 (d, J= 13.9, IH), 3.57- 3.64 (m, 3H), 4.09 (t, J= 10.5, IH), 4.18 (d, J= 2.6, IH), 5.14 (q, J= 6.4, IH), 6.90 (s, IH), 7.11 (t, J= 8.7, 2H), 7.48 (m, 2H), 7.72 ( d, J= 8.3, IH), 7.83 (d, J= 8.3, IH), 8.36 (br s), 13.8 (s, IH). EXAMPLE 93 2-(R)-(l-(R)-(2,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl V4-(4-(2-oxo- 1 -imidazolo methyl-moφholine The title compound was prepared from 2-(R)-(l-(R)-(2,5- bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)-moφholine (from Example 90) using a procedure analogous to Example 83. A sample was recrystallized from aqueous ethanol, mp 203-205 °C. lH NMR (d6-DMSO, 360 MHz, ppm): δ 1.35 (d, J= 6.4, 3H), 2.25 (dt, J= 3.1, 11.8, IH), 2.58 (d, J= 13.9, IH), 2.88 (d, J= 11.6, IH), 3.24 (d, J= 14.0, IH), 3.35 (d, J= 2.7, IH), 3.64 (dd, J= 9.6, IH), 4.09 (t, J= 9.8, IH), 4.16 (d, J= 2.7, IH), 5.14 (q, J= 6.5, IH), 5.97 (s, IH), 6.89 (s, IH), 7.07 (t, J= 8.7, IH), 7.49 (m, IH), 7.72 (d, J= 8.1, IH), 7.83 (d, J= 8.3, IH), 9.57 (s, IH), 9.80 (s, IH). EXAMPLE 94 Typical Pharmaceutical Compositions Containing a Compound of the Invention A: Dry Filled Capsules Containing 5 mg of Active Ingredient Per Capsule Ingredient Amount per capsule (mg Active ingredient 5 Lactose 194 Magnesium stearate 1 Capsule (size No. 1) 200 The active ingredient may be reduced to a No. 60 powder and the lactose and magnesium stearate may then be passed through a No. 60 blotting cloth onto the powder. The combined ingredients may then be mixed for about 10 minutes and filled into a No. 1 dry gelatin capsule. B: Tablet A typical tablet would contain the active ingredient (25 mg), pregelatinized starch USP (82 mg), microcrystalline cellulose (82 mg) and magnesium stearate (1 mg). C: Suppository Typical suppository formulations for rectal administration contain the active ingredient (0.08-1.0 mg), disodium calcium edetate (0.25-0.5 mg), and polyethylene glycol (775-1600 mg). Other suppository formulations may be made by substituting, for example, butylated hydroxytoluene (0.04-0.08 mg) for the disodium calcium edetate and a hydrogenated vegetable oil (675-1400 mg) such as Suppocire L, Wecobee FS, Wecobee M, Witepsols, and the like, for the polyethylene glycol. D: Injection A typical injectible formulation contains the active ingredient, sodium phosphate dibasic anhydrous (11.4 mg), benzyl alcohol (0.01 ml) and water for injection (1.0 ml). While the invention has been described and illustrated with reference to certain particular embodiments thereof, those skilled in the art will appreciate that various adaptations, changes, modifications, substitutions, deletions, or additions of procedures and protocols may be made without departing from the spirit and scope of the invention. For example, effective dosages other than the particular dosages as set forth herein above may be applicable as a consequence of variations in the responsiveness of the mammal being treated for any of the indications with the compounds of the invention indicated above. Likewise, the specific pharmacological responses observed may vary according to and depending upon the particular active compounds selected or whether there are present pharmaceutical carriers, as well as the type of formulation and mode of administration employed, and such expected variations or differences in the results are contemplated in accordance with the objects and practices of the present invention. It is intended, therefore, that the invention be defined by the scope of the claims which follow and that such claims be interpreted as broadly as is reasonable.

Claims: WHAT IS CLAIMED IS: 1. A compound of the structural formula: or a pharmaceutically acceptable salt thereof, wherein: Rl is selected from the group consisting of: (1) hydrogen; (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d)* phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, wherein halo is fluoro, chloro, bromo or iodo, (h) -NR9R10, wherein R9 and RlO are independently selected from: (i) hydrogen, (ii) Cl-6 alkyl, (iii) hydroxy-Cl -6 alkyl, and (iv) phenyl, (i) -NR9COR 10, wherein R9 and R 10 are as defined above, (j) -NR C02R10, wherein R9 and RlO are as defined above, 10 15 20 25 30 (AC) tetrahydrofuranyl, and (AD) tetrahydrothienyl, and wherein the heterocycle is unsubstituted or substituted with one or more substituent(s) selected from: (i) Cl-6 alkyl, unsubstituted or substituted with halo, -CF3, -OCH3, or phenyl, (ii) Cl-6 alkoxy, (iii) oxo, (iv) hydroxy, (v) thioxo, (vi) -SR9, wherein R9 is as defined above, (vii) halo, (viii) cyano, (ix) phenyl, (x) trifluoromethyl, (xi) -(CH2) m -NR9R 10, wherein m is 0, 1 or 2, and R9 and RlO are as defined above, (xii) -NR9COR10, wherein R9 and RlO are as defined above, (xiii) -CONR9R10, wherein R9 and RlO are as defined above, (xiv) -CO2R9, wherein R9 is as defined above, and (xv) -(CH2)m- R9, wherein m and R9 are as defined above; (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, above, (k) -NR C02R!0, wherein R9 and RlO are as defined above, (1) -C0NR9R 10, wherein R9 and R 10 are as defined above, (m) -CO2NR9R10, wherein R9 and RlO are as defined above, (n) -C0R9, wherein R9 is as defined above; (o) -C02R9, wherein R9 is as defined above; R3 are independently selected from the group consisting of: (1) hydrogen, (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR9R10, wherein R9 and RlO are as defined above, (i) -NR9COR10, wherein R9 and RlO are as defined above, (j ) -NR9C02R 10, wherein R9 and R 10 are as defined above, (k) -CONR9R10, wherein R9 and RlO are as defined above, (1) -COR9, wherein R9 is as defined above, and (m) -C02R9, wherein R9 is as defined above; (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR9R 10 wherein R9 and Rl 0 are as defined above, (i) -COR9 wherein R9 is as defined above, (j) -C02 9, wherein R9 is as defined above; (4) C2-6 alkynyl; (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) Cl-6 alkoxy, (c) Cl-6 alkyl, (d) C2-5 alkenyl, (e) halo, (f) -CN, (g) -N02, (h) -CF3, (i) -(CH2)m-NR9R lO, wherein m, R9 and RlO are as defined above, (j) -NR9COR10, wherein R9 and RlO are as defined above, (k) -NR9C02 10, wherein R9 and R 10 are as defined above, (1) -CONR9R 10, wherein R9 and R 10 are as defined above, (m) -C02NR9R 10, wherein R9 and R 10 are as defined above, (n) -COR9, wherein R is as defined above; (o) -C02R9, wherein R9 is as defined above; and the groups Rl and R2 may be joined together to form a heterocyclic ring selected from the group consisting of: (a) pyrrolidinyl, (b) piperidinyl, (c) pyrrolyl, (d) pyridinyl, (e) imidazolyl, (f) oxazolyl, and (g) thiazolyl, and wherein the heterocyclic ring is unsubstituted or and the groups R2 and R3 may be joined together to form a carbocyclic ring selected from the group consisting of: (a) cyclopentyl, (b) cyclohexyl, (c) phenyl, and wherein the carbocyclic ring is unsubstituted or substituted with one or more substituents selected from: (i) Ci-6alkyl, and wherein the heterocyclic ring is unsubstituted or substituted with one or more substituent(s) selected from: (i) Ci-6alkyl, (ii) oxo, (iii) Ci-6alkoxy, (iv) -NR9R 10, wherein R9 and RlO are as defined above, (v) halo, and (vi) trifluoromethyl; R6, R7 and R8 are independently selected from the group consisting of: (1) hydrogen; (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, .(c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) * -NR9R 10, wherein R9 and RlO are as defined above, (i) -NR9COR 10, wherein R9 and RlO are as defined above, (j ) -NR9C02R 1 , wherein R9 and R 10 are as defined above, (k) -CONR9R10, wherein R9 and RlO are as defined above, (1) -COR9, wherein R9 is as defined above, and (m) -C02 9, wherein R9 is as defined above; (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR9R 10 wherein R9 and R 10 are as defined above, (i) -COR9 wherein R9 is as defined above, (j) -C02R9, wherein R9 is as defined above; (4) C2-6 alkynyl; (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) Cl-6 alkoxy, (c) Cl-6 alkyl, (d) C2-5 alkenyl, (e) halo, (f) -CN, (g) -N02, (h) -CF3, (i) -(CH2)m-NR9RlO, wherein m, R9 and RlO are as defined above, (j) -NR9COR10, wherein R9 and RlO are as defined above, (k) -NR9CO2R10, wherein R9 and RlO are as defined above, (1) -C0NR9R 10, wherein R9 and R 10 are as defined above, (m) -CO2NR9R10, wherein R9 and RlO are as defined above, (n) -C0R9, wherein R9 is as defined above; (o) -C02R9, wherein R9 is as defined above; (6) halo, (7) -CN, (8) -CF3, (9) -N02, (10) -SR14, wherein Rl4 is hydrogen or Cl-5alkyl, (11) -SOR1 , wherein R 1 is as defined above, (12) -Sθ2Rl4, wherein Rl4 is as defined above, (13) NR9COR 0, wherein R9 and R 10 are as defined above, (14) CONR9COR10, wherein R9 and RlO are as defined above, (15) NR9R10, wherein R9 and RlO are as defined above, (16) NR9C02R 10 , wherein R9 and RlO are as defined above, (17) hydroxy, (18) Ci-6alkoxy, (19) COR9, wherein R9 is as defined above, (20) C02R9, wherein R9 is as defined above, (21) 2-pyridyl, (22) 3-pyridyl, (23) 4-pyridyl, (24) 5-tetrazolyl, (25) 2-oxazolyl, and (26) 2-thiazolyl; Rl l, Rl2 and Rl3 are independently selected from the definitions of R6, R7 and R8; X is selected from the group consisting of: (1) -o-, (2) -S-, (3) -SO-, and (4) -S02-; Y is selected from the group consisting of: (1) a single bond, (2) -0-, (3) -S-, (4) -CO-, (5) -CH2-, (6) -CHR1 -, and (7) -CR15R16-, wherein Rl5 and Rl are independently selected from the group consisting of: (a) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (i) hydroxy, (ii) oxo, (iii) Cl-6 alkoxy, (iv) phenyl-Cl-3 alkoxy, (v) phenyl, (vi) -CN, (vii) halo, (viii) -NR9R10, wherein R9 and RlO are as defined above, (ix) -NR9COR 10, wherein R and RlO are as defined above, (x) -NR9C02R 10 , wherein R9 and RlO are as defined above, (xi) -CONR9R 10, wherein R9 and RlO are as defined above, (xii) -COR9, wherein R9 is as defined above, and (xiii) -C02R9, wherein R9 is as defined above; (b) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (i) hydroxy, (ii) Cl-6 alkoxy, (iii) Cl-6 alkyl, (iv) C2-5 alkenyl, (v) halo, (vi) -CN, (vii) -N02, (viii) -CF3, (ix) -(CH2) m -NR9RlO, wherein m, R9 and RlO are as defined above, (x) -NR9COR 10, wherein R9 and RlO are as defined above, (xi) -NR9C02R 10, wherein R9 and R 10 are as defined above, (xii) -CONR9R 10, wherein R9 and RlO are as defined above, (xiii) -CO2NR9R10, wherein R9 and RlO are as defined above, (xiv) -COR9, wherein R9 is as defined above, and (xv) -C02R9, wherein R9 is as defined above; and Z is Cl-6 alkyl. (ix) trifluoromethyl, and (x) -(CH2)m-NR9RlO, wherein m is 0, 1 or 2. and wherein R9 and RlO are independently selected from: (I) hydrogen, (II) Cl-6 alkyl, (III) hydroxy-Cl-6 alkyl, and (IV) phenyl, (xi) -NR9COR10, wherein R9 and RlO are as defined above, and (xii) -CONR9R10, wherein R9 and RlO are as defined above. 3. The compound of Claim 1 wherein: R2 and R3 are independently selected from the group consisting of: (1) hydrogen, (2) Cl-6 alkyl, (3) C2-6 alkenyl, and (4) phenyl; (6) iodo, and (7) -CF ; X is -0-; Y is -0-; and Z is Cl-4 alkyl. 4. The compound of Claim 1 wherein Z is Cl-4 alkyl. 5. The compound of Claim 1 wherein Z is -CH3. 6. The compound of Claim 1 wherein Rl is selected from the group consisting of: 7. The compound of Claim 1 wherein Rl is selected from the group consisting of: (l,2,4-triazolo)methyl; and (5-oxo-lH,4H-l,2,4-triazolo)methyl. 8. The compound of Claim 1 wherein Rl is selected from the group consisting of: (l,3-imidazolo)methyl; and (2-oxo- 1 ,3-imidazolo)methyl. 9. The compound of Claim 1 of the structural formula: or a pharmaceutically acceptable salt thereof, wherein Rl, R2, R3, R6, R7, R8, Rl l, Rl2, Rl3, y and Z are as defined in Claim 1. 10. The compound of Claim 1 of the structural formula II: or a pharmaceutically acceptable salt thereof, wherein Rl, R2, R3, R6, R7, R8, Rl l, Rl2, Rl3 and Z are as defined in Claim 1. 11. The compound of Claim 1 of the structural formula III: or a pharmaceutically acceptable salt thereof, wherein Rl, R2, R3, R6, R7, R8, Rl l, Rl2, Rl3 and Z are as defined in Claim 1. 12. The compound of Claim 1 of the structural formula: or a pharmaceutically acceptable salt thereof, wherein Rl, R2, R3, R6, R7, R8, Rl l, Rl2, Rl3, y and Z are as defined in Claim 1. 13. The compound of Claim 1 of the structural formula: or a pharmaceutically acceptable salt thereof, wherein Rl, R2, R3, R6, R7, R8, Rl l, R12, R13, y and Z are as defined in Claim 1. 14. The compound of Claim 1 of the structural formula: or a pharmaceutically acceptable salt thereof, wherein Rl, R2, R3, R6, R7, R8, Rl l, Rl2, R13, y and Z are as defined in Claim 1. 15. A compound which is selected from the group consisting of: 87) 2-(R)-(l-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-moφholine; 88) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-morpholine; 89) 2-(R)-(l-(S)-(3,5-Bis(trifluoiOmethyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl-moφholine; 90) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl-moφholine; 93) 2-(R)-(l-(S) ' -(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 94) 2-(R)-(l-(R) ' -(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 95) 2-(R)-(l-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- moφholine; 96) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl- moφholine; 98) 2-(R)-(l-(R)-(l-(3-(methyl)naphthyl))ethoxy)-3-(S)-phenyl-4-(4- (2-oxo-l,3-imidazolo)methyl-morpholine; 99) 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-morpholine; 100) 2-(R)-(l-(R)-(3-(fluoro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo-l H,4H-l ,2,4-triazolo)methyl)- moφholine; 101) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-moφholine; 102) 2-(R)-(l-(R)-(3-(chloro)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 103) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 104) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo-lH,4H-l ,2,4-triazolo)methyl)-morpholine; 105) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 106) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(5-oxo-lH,4H- l,2,4-triazolo)methyl)-moφholine; 107) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)- phenyl-morpholine; 108) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 109) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)- phenyl-morpholine; 110) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 111) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 112) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 113) 2-(R)-(l-(R)-(3-(isopropoxy)-5-trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-morpholine ; 114) 2-(R)-(l-(R)-(3-(isopropoxy)-5-trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 115) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-morphol ine ; 116) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxθ- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 117) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-moφholine ; 118) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 121) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 122) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)-moφholine; 123) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-morpholine; 124) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 125) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-morpholine; 126) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)-moφholine; 127) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- pheny 1-morpholine; 128) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 129) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-morpholine; 130) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 131) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-chloro)phenyl)ethoxy)- 3-(S)-phenyl-morpholine; 132) 2-(R)-(l-(R)-(3,5-bis(trifluoiomethyl)-4-chloro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 133) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 134) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- 1 H,4H- 1 ,2 ,4-triazol o)methyl)-moφholine; 135) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 136) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo- lH,4H-l,2,4-triazolo)methyl)-moφholine; 153) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- pheny 1-moφholine ; 154) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 157) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 158) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 161) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)-moφholine; 162) 2-(R)-(l-(R)-(2-fluoiO-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 165) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 166) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 169) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-imidazolo)methyl-morpholine; 170) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl-morpholine; 173) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-imidazolo)methyl-moφholine; 174) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-morpholine; 177) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(5-tetrazolo)methyl-morpholine; 178) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-morpholine; 181) 2-(R)-(l-(R)-(2-fluoro-5-trifluoiOmethyl)phenylethoxy)-3-(S)- phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 182) 2-(R)-(l-(R)-(2-fluoro-5-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 185) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- pheny 1-morpholine; 186) 2-(R)-(l-(R)-(2-chloiO-5-trifluoiOmethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-morpholine; 189) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 190) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)ρhenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 193) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(3-(5-oxo-lH,4H- l ,2,4-triazolo)methyl)-moφholine; 194) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 197) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 198) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-(2-oxo-l ,3-imidazolo)methyl)-moφholine; 201) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-imidazolo)methyl)-morpholine; 202) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(2-imidazolo)methyl)-morpholine; 205) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(4-imidazolo)methyl-morpholine; 206) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-imidazolo)methyl-morpholine; 209) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(5-tetrazolo)methyl-morpholine; 210) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(5-tetrazolo)methyl-moφholine; 213) 2-(R)-(l-(R)-(2-chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 214) 2-(R)-(l-(R)-(2-Chloro-5-trifluoromethyl)phenylethoxy)-3-(S)- (4-fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 217) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-moφholine; 218) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 221) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(3-( 1,2,4- triazolo)methyl)-moφholine; 222) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-( 1 ,2,4-triazolo)methyl )-morpholine; 225) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- l,2,4-triazolo)methyl)-morpholine; 226) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H- l ,2,4-triazolo)methyl )-morpholine; 229) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- l,3-imidazolo)methyl)-morpholine; 230) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo-l ,3-imidazolo)methyl)-morpholine; 233) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-morpholine; 234) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)ρhenyl-4- (2-imidazolo)methyl-morpholine; 237) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-morpholine; 238) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-morpholine; 241) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methyl-morpholine; 242) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-morpholine; 245) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-morpholine; 246) 2-(R)-(l-(R)-(3-methyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-morpholine; 249) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-moφholine; 250) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 253) 2-(R)-(l-(R)-(3-biOmo)phenylethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methy 1-morpholine; 254) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl-morpholine; 257) 2-(R)-( 1 -(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- lH,4H-l,2,4-triazolo)methyl)-morpholine; 258) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H- 1 ,2,4-triazolo)methyl)-morpholine; 261) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- l,3-imidazolo)methyl)-morpholine; 262) 2-(R)-( 1 -(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl)-morpholine; 265) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-moφholine; 266) 2-(R)-( 1 -(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-morpholine; 269) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-morpholine; 270) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-morpholine; 273) 2-(R)-( 1 -(R)-(3-bromo)pheny lethoxy )-3-(S)-phenyl-4-(5- tetrazolo)methyl-morpholine; 274) 2-(R)-(l-(R)-(3-biOmo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-morpholine; 277) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methyl-morpholine; 278) 2-(R)-(l-(R)-(3-bromo)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-morpholine; 281) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-moφholine; 282) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 285) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl)-morpholine; 286) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl)-morpholine; 289) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- lH,4H-l,2,4-triazolo)methyl)-morpholine; 290) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H- 1 ,2,4-triazolo)methyl)-morpholine; 293) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- l,3-imidazolo)methyl)-morpholine; 294) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl)-morpholine; 297) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-morpholine; 298) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-morρholine; 301) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-morpholine; 302) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-imidazolo)methyl-morpholine; 305) 2-(R)-( 1 -(R)-(3-chloro)phenylethoxy)-3-(S)-ρhenyl-4-(5- tetrazolo)methyl-morpholine; 306) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (5-tetrazolo)methyl-morpholine; 309) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-phenyl-4-(2-oxo-5H- pyrrol-4-yl)methy 1-morpholine; 310) 2-(R)-(l-(R)-(3-chloro)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-morpholine; 313) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl- moφholine; 314) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 317) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (3-lH,4H-l,2,4-triazolo)methyl-morpholine; 318) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl-morpholine; 321) 2-(R)-(l-(R)-(3-trifluoiOmethyl)phenylethoxy)-3-(S)-phenyl-4- (3-(5-oxo-lH,4H- l ,2,4-triazolo)methyl)-moφholine; 322) 2-(R)-(l-(R)-(3-trifluoiOmethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 325) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl)-morρholine; 326) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 329) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (2-imidazolo)methyl-morpholine; 330) 2-(R)-(l-(R)-(3-trifluoiOmethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-imidazolo)methyl-morpholine; 333) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (4-imidazolo)methyl-morpholine; 334) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-imidazolo)methyl-morpholine; 337) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (5-tetrazolo)methyl-morpholine; 338) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(5-tetrazolo)methyl-morpholine; 341) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-phenyl-4- (2-oxo-5H-pyrrol-4-yl)methyl-morpholine; 342) 2-(R)-(l-(R)-(3-trifluoromethyl)phenylethoxy)-3-(S)-(4- fluoro)phenyl-4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 345) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-moφholine; 346) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 349) 2-(R)-(l-(R)-(3-t-butyl)ph .. _ylethoxy )-3-(S)-phenyl-4-(3-( 1,2,4- triazolo)methy l)-morpholine ; 350) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl)-morpholine; 353) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(3-(5-oxo- lH,4H-l,2,4-triazolo)met yl)-morpholine; 354) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H-l ,2,4-triazolo)methyl)-moφholine; 357) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(4-(2-oxo- l,3-imidazolo)methyl-morpholine; 358) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl)-morpholine; 361) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(2- imidazolo)methyl-morpholine; 362) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (2-imidazolo)methyl-morpholine; 365) 2-(R)-(l-(R)-(3-t-butyl)phenylethoxy)-3-(S)-phenyl-4-(4- imidazolo)methyl-morpholine; 366) 2-(R)-(l-(R)-(3-(t-butyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- 4-(4-imidazolo)methyl-morpholine; 369) 2-(R)-(l-(R)-(3-(t-butyl)phenyl)ethoxy)-3-(S)-phenyl-4-(5- tetrazolo)methyl-morpholine; 370) 2-(R)-(l-(R)-(3-(t-butyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- 5 4-(5-tetrazolo)methyl-morpholine; 373) 2-(R)-(l-(R)-(3-(t-butyl)phenyl)ethoxy)-3-(S)-phenyl-4-(2-oxo- 5H-pyrrol-4-yl)methyl-morpholine; 10 374) 2-(R)-(l-(R)-(3-(t-butyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- 4-(2-oxo-5H-pyrrol-4-yl)methyl-moφholine; 378) 2-(R)-(l-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluoropheny l)-morpholine ; 15 379) 2-(R)-(l-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; "20 380) 2-(R)-(l-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 381) 2-(R)-(l-(R)-(2,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4- fluorophenyl)-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 25 382) 2-(R)-(l-(R)-(3-(thiomethyl)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 383) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- 3 o oxo- 1H,4H- 1 ,2,4-triazolo)methyl)-morpholine; 384) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-morpholine; 385) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl)-morpholine; 386) 2-(R)-(l-(R)-(3-(thiomethyl)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-morpholine: 387) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 388) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 389) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 394) 2-(R)r(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl- moφholine; 395) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (5-oxo-lH,4H- l ,2.4-triazolo)methyl)-morpholine; 396) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-morpholine; 397) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(4- (2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 398) 2-(R)-(l-(R)-(3-(fluoiO)-5-(trifluoromethyl)phenyl)-ethoxy)-3- (S)-(4-fluorophenyl)-morpholine; 399) 2-(R)-(l-(R)-(3-(fluoiOphenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 400) 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 401) 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 402) 2-(R)-(l-(R)-(3-(chloro)-5-(trirluoromethyl)phenyl)-ethoxy)-3- (S)-(4-fluoro)phenyl-morpholine; 403) 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 404) 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 405) 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- (4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 406) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 407) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 408) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 409) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 410) 2-(R)-(l-(R)-(3-(fluoiO)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 411) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-l H,4H-l,2,4-triazolo)methyl)- moφholine; 412) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 413) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 414) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 415) 2-(R)-(l-(R)-(3-(chloiO)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 416) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 417) 2-(R)-(l-(R)-(3-(chloiO)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 418) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 419) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 420) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 421) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 422) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 423) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 424) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 425) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 426) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)ρhenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-morpholine; 427) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4- triazolo)methyl)-morpholine; 428) 2-(R)-(l-(R)-(3-(isopiOpoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-( l ,2,4-triazolo)methyl)-moφholine; 429) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 430) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 431) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H.4H- 1 ,2,4-triazolo)methyl)- moφholine; 432) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 433) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 434) 2-(R)-(l-(R)-(3-(fluoiO)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 435) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 436) 2-(R)-(l-(R)-(3-(fluoiO)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 437) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 438) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloiO)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 439) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4-triazolo)methyl)- moφholine; 440) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 441) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 442) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-morpholine; 443) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 444) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-moφholine; 445) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 446) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 447) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 448) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 449) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 450) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 451) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- lH,4H-l,2,4-triazolo)methyl)- moφholine; 452) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 453) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 454) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-morpholine; 455) 2-(R)-(l-(R)-(3,5-bis(tπfluoiOmethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5÷oxo-lH,4H-l,2,4- triazolo)methyl)-morpholine; 456) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(l ,2,4-triazolo)methyl)-moφholine; 457) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(fluoro)phenyl)ethoxy)- 33--((SS))--((44--fflluuooro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 458) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-ιτιorpholine; 459) 2-(R)-(l-(R)-(3,5-bis(tdfluoiOmethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4- triazolo)methyl)-morpholine; 460) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)-4-(chloro)ρhenyl)ethoxy)- 3-(S)-(4-fluoiO)phenyl-4-(3-( l ,2,4-triazolo)methyl)-moφholine; 461) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)ρhenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 462) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholinc; 463) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 464) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 465) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 466) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 467) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-tπazolo)methyl)- moφholine; 468) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 469) 2-(R)-(l-(R)-(3,5-(difluoro)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 494) 2-(R)-(l-(R)-(3-(thiomethyl)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine : 495) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 496) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 497) 2-(R)-(l-(R)-(3-(thiomethylphenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 498) 2-(R)-(l-(R)-(3-(thiomethyl)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-morpholine; 499) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-lH,4H-l,2,4- triazolo)methyl)-morpholine; 500) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 501) 2-(R)-(l-(R)-(3-(thiomethyl-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-(4-fluoro)phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)- moφholine; 506) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-morpholine; 507) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 508) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(3-( 1 ,2,4-tπazolo)methyl)-morpholine; 509) 2-(R)-(l-(R)-(3,5-(dimethoxy)phenyl)ethoxy)-3-(S)-(4- fluoro)phenyl-4-(4-(2-oxo- 1 ,3- imidazolo)methyl)-moφholine; 510) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-moφholine; 511) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5-oxo-lH,4H- l,2,4-triazolo)methyl)-morpholine; 512) 2-(R)-(l-(R)-(phenyl)ethoxy .-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl)-morpholine; 513) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2-oxo-l,3- imidazolo)methyl)-morpholine; 514) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl moφholine; 515) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5- oxo-lH,4H-l ,2,4-tπazolo)methyl)-morpholine; 516) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(l,2,4- triazolo)methyl)-morpholine; 517) 2-(R)-(l-(R)-(phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(4-(2- oxo- 1 ,3-imidazolo )methy 1 )-morpholine; 518) 2-(R)-(l-(R)-(3-(fluoiO)phenyl)ethoxy)-3-(S)-phenyl-moφholine; 519) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo-lH,4H-l,2,4-triazolo)methyl)-morpholine; 520) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl)-morpholine; 521) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl )-morpholine; 522) 2-(R)-(l-(R)-(3-(fluoiO)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 523) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H- 1.2,4-triazolo)methyl)-moφholine; 524) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-( 1 ,2,4-triazolo)methy 1 )-morpholine; 525) 2-(R)-(l-(R)-(3-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo-l ,3-imidazolo)methyl)-moφholine; 526) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-ρhenyl-moφholine; 527) 2-(R)-(l-(R)-(4-(nuoro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(5- oxo-lH,4H- l,2,4-triazolo)methyl)-morpholine; 528) 2-(R)-(l-(R)-(4-(fluoiO)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(l,2,4- triazolo)methyl)-morpholine; 529) 2-(R)-(l-(R)-(4-(fluoiO)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo- 1 ,3-imidazolo)methyl )-morpholine; 530) 2-(R)-(l-(R)-(4-(fluoiO)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl- moφholine; 531) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(5-oxo-lH,4H- l ,2.4-tπazolo)methyl)-moφholine; 532) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-(l,2,4-triazolo)methyl)-morpholine; 533) 2-(R)-(l-(R)-(4-(fluoro)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4- (4-(2-oxo- 1 ,3-imidazolo)methyl)-morpholine; 534) 2-(R)-(l-(R)-(3,5-bis(triπuoiOmethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-morpholine; 535) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(3-(5-oxo- 1 H.4H- 1 ,2,4-triazolo)methyl)- moφholine; 536) 2-(R)-(l-(R)-(3,5-bis(tdfluoiOmethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 537) 2-(R)-(l-(R)-(3,5-bis(tπfluoromethyl)phenyl)ethoxy)-3-(S)-(3- fluoro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 538) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-morpholine; 539) 2-(R)-(l-(R)-(3,5-bis(tπfluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 540) 2-(R)-(l-(R)-(3,5-bis(tdfluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(3-( 1 ,2,4-tπazolo)methyl)-morpholine; 541) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)phenyl)ethoxy)-3-(S)-(3,4- difluoro)phenyl-4-(4-(2-oxo- 1.3-imidazolo)methyl)-moφholine; 542) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-morpholine; 543) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(3-(5-oxo- l H,4H-l,2,4-triazolo)methyl)- moφholine; 544) 2-(R)-(l-(R)-(3,5-bis(tπfluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(3-( 1 ,2,4-triazolo)methyl)-morpholine; 545) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)phenyl)ethoxy)-3-(S)-(3,4- dichloro)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 546) 2-(R)-(l-(R)-(3,5-bis(tι-ifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-morpholine; 547) 2-(R)-(l-(R)-(3,5-bis(tπfluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)- moφholine; 548) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(3-( 1 ,2,4-tπazolo)methyl)-moφholine; 549) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)phenyl)ethoxy)-3-(S)-(3,4- dimethyl)phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 550) 2-(R)-(l-(R)-(3,5-bis(trinuoiOmethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-morpholine; 551) 2-(R)-(l-(R)-(3,5-bis trifluoiOmethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxypheny ] -4-(3-(5-oxo- lH,4H-l,2,4-triazolo)methyl)- morpholine; 552) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-4-( 3-( 1 ,2,4-triazolo)methyl)-mθφholine; 553) 2-(R)-(l-(R)-(3,5-bis(ti-ifluoromethyl)phenyl)ethoxy)-3-(S)-3,4- methylenedioxyphenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)- moφholine; 554) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-morpholine; 555) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(3-(5-oxo- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 556) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(3-(l,2,4-triazolo)methyl)-morpholine; 557) 2-(R)-(l-(R)-(3,5-bis(tπfluoromethyl)phenyl)ethoxy)-3-(S)-(2- naphthyl)-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 0 558) 2-(R)-(l-(R)-(3-(fluoiOphenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-morpholine; 559) 2-(R)-(l-(R)-(3-(fluorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-morpholine; 5 560) 2-(R)-(l-(R)-(3-(chloiOphenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- phenyl-4-(3-(l ,2,4-tπazolo)methyl)-morpholine; 561) 2-(R)-(l-(R)-(3-(chlorophenyl)-5-(trifluoromethyl)ethoxy)-3-(S)- ° phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-morpholine; 562) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-nιorpholine; 563) 2-(R)-(l-(R)-(3,5-(dimethyl)phenyl)ethoxy)-3-(S)-phenyl-4-(4- (2-oxo-l,3-imidazolo)methyl)-morpholine; 564) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(l,2,4-triazolo)methyl)-morpholine; 565) 2-(R)-(l-(R)-(3-(fluoro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-morpholine; 10 566) 2-(R)-(l -(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(-lH,4H- 1 ,2,4-triazolo)methyl)-morpholine; 567) 2-(R)-(l-(R)-(3-(chloro)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-morpholine; 15 568) 2-(R)-(l-(R)-(3-(bromo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(l,2,4-triazolo)methyl)-morpholine; 569) 2-(R)-(l-(R)-(3-(biOmo)-5-(methyl)phenyl)ethoxy)-3-(S)-phenyl- • 20 4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-morpholine; 570) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(3- 25 571) 2-(R)-(l-(R)-(3-(isopropoxy)phenyl)ethoxy)-3-(S)-phenyl-4-(4- (2-oxo-l,3-imidazolo)methyl)-morpholine; 572) 2-(R)-(l-(R)-(3-(isopiOpoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(- 1 H,4H- 1 ,2,4-triazolo)methyl)-moφholine; 30 573) 2-(R)-(l-(R)-(3-(isopropoxy)-5-(trifluoromethyl)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 574) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(-lH,4H-l ,2,4-triazolo)methyl)-moφholine; 575) 2-(R)-(l-(R)-(3-(chloro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-morpholine; 576) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(-lH,4H-l,2,4-triazolo)methyl)-moφholine; 577) 2-(R)-(l-(R)-(3-(fluoro)-5-(isopropoxy)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 578) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(3-(- 1H.4H- 1 ,2,4-triazolo)methyl)-moφholine; 579) 2-(R)-(l-(R)-(3-(t-butyl)-5-(chloro)phenyl)ethoxy)-3-(S)-phenyl- 4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 580) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- ' (S)-phenyl-4-(3-(-lH,4H-l ,2,4-triazolo)methyl)-moφholine; 581) 2-(R)-(l-(R)-(3-(t-butyl)-5-(trifluoromethyl)phenyl)ethoxy)-3- (S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 582) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(l,2,4-triazolo)methyl)-moφholine; 583) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(fluoro)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo-l,3-imidazolo)methyl)-morpholine; 584) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(3-(-lH,4H-l,2,4-triazolo)methyl)-morpholine; 585) 2-(R)-(l-(R)-(3,5-(dimethyl)-4-(chloro)phenyl)ethoxy)-3-(S)- phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 586) 2-(R)-(l-(R)-(3,5-bis(trifluoiOmethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(-lH,4H- 1 ,2,4-triazolo)methyl)-moφholine; 587) 2-(R)-(l-^(R)-(3,5-bis(trifluoiOmethyl)-4-(fluoro)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 588) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-phenyl-4-(3-(-lH,4H-l,2,4-triazolo)methyl)-moφholine; 589) 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)-4-(chloro)phenyl)ethoxy)- 3-(S)-phenyl-4-(4-(2-oxo- 1 ,3-imidazolo)methyl)-moφholine; 590) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(3-(- lH,4H-l,2,4-triazolo)methyl)-morpholine; 591) 2-(R)-(l-(R)-(3,5-(dichloro)phenyl)ethoxy)-3-(S)-phenyl-4-(4-(2- oxo-l,3-imidazolo)methyl)-morpholine; 592) 2-(R)-(l-(R)-(3,5-(difluoiO)phenyl)ethoxy)-3-(S)-phenyl-4-(3- (l,2,4-triazolo)methyl)-morpholine; 593) 2-(R)-(l-(R)-(3,5-(difluoiO)phenyl)ethoxy)-3-(S)-phenyl-4-(4- ' (2- oxo-l,3-imidazolo)methyl)-morpholine; or a pharmaceutically acceptable salt thereof. 16. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount of the compound of Claim 1. 17. A method for antagonizing the effect of substance P at its receptor site or for the blockade of neurokinin- 1 receptors in a mammal which comprises the administration to the mammal of the compound of Claim 1 in an amount that is effective for antagonizing the effect of substance P at its receptor site in the mammal. 18. A method for antagonizing the effect of neurokinin A at its receptor site or for the blockade of neurokinin-2 receptors in a mammal which comprises the administration to the mammal of the compound of Claim 1 in an amount that is effective for antagonizing the effect of neurokinin A at its receptor site in the mammal. 19. A method of treating or preventing pain or nociception attributable to or associated with migraine in a mammal in need thereof which comprises the administration to the mammmal of an effective amount of the compound of Claim 1. 20. A method of treating or preventing a condition selected from the group consisting of: diabetic neuropathy; peripheral neuropathy; AIDS related neuropathy; chemotherapy-induced neuropathy; and neuralgia, in a mammal in need thereof which comprises the administration to the mammal of an effective amount of the compound of Claim 1. 21. A method for the treatment or prevention of asthma in a mammal in need thereof which comprises the administration to the mammal of an effective amount of the compound of Claim 1, either alone or in combination with a neurokinin-2 receptor antagonist or with a β2-adrenergic receptor agonist. 22. A method for the treatment of cystic fibrosis in a mammal in need thereof which comprises the administration to the mammal of an effective amount of the compound of Claim 1. 23. A method for the treatment or prevention of emesis in a mammal in need thereof which comprises the administration to the mammal of an effective amount of the compound of Claim 1. 24. A process for the preparation of a compound of structural formula IV: IV or a pharmaceutically acceptable salt thereof, wherein: Rl is selected from the group consisting of: (1) hydrogen; (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, wherein halo is fluoro, chloro, bromo or iodo, (h) -NR9R10, wherein R9 and RlO are independently selected from: (i) hydrogen, (ii) Cl-6 alkyl, (iii) hydroxy-Ci-6 alkyl, and (iv) phenyl, (i) -NR9COR10, wherein R9 and RlO are as defined above, (j ) -NR9C02R 10, wherein R9 and R 10 are as defined above, 10 15 20 25 30 (AC) tetrahydrofuranyl, and (AD) tetrahydrothienyl, and wherein the heterocycle is unsubstituted or substituted with one or more substituent(s) selected from: (i) Cl-6 alkyl, unsubstituted or substituted with halo, -CF3, -OCH3, or phenyl, (ii) Cl-6 alkoxy, (iii) oxo, (iv) hydroxy, (v) thioxo, (vi) -SR9, wherein R9 is as defined above, (vii) halo, (viii) cyano, (ix) phenyl, (x) trifluoromethyl, (xi) -(CH2)m-NR9RlO, wherein m is 0, 1 or 2, and R9 and RlO are as defined above, (xii) -NR9COR10, wherein R9 and RlO are as defined above, (xiii) -CONR9R10, wherein R9 and RlO are as defined above, (xiv) -C02R , wherein R9 is as defined above, and (xv) -(CH2)m-OR9, wherein m and R9 are as defined above; (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR9R10 wherein R9 and RlO are as defined above, (i) -COR9 wherein R9 is as defined above, (j) -C02R9, wherein R9 is as defined above, (k) heterocycle, wherein the heterocycle is as defined above; (4) C2-6 alkynyl; (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) Cl-6 alkoxy, (c) Cl-6 alkyl, (d) C2-5 alkenyl, (e) halo, (f) -CN, (g) -N02, ( ) -CF 3 , (i) -(CH2)m-NR9RlO, wherein m, R9 and RlO are as defined above, G) -NR9COR10, wherein R9 and RlO are as defined above, (k) -NR9C02R 10, wherein R9 and R 10 are as defined above, (1) -CONR9R10, wherein R9 and RlO are as defined above, (m) -C02NR9R 10, wherein R9 and R 10 are as defined above, (n) -COR9, wherein R9 is as defined above; (o) -C02R9, wherein R9 is as defined above; R3 are independently selected from the group consisting of: (1) hydrogen, (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR9R10, wherein R9 and RlO are as defined above, (i) -NR9COR10, wherein R9 and RlO are as defined above, (j) -NR9C02R! Q , wherein R9 and RlO are as defined above, (k) -CONR9R 10, wherein R9 and RlO are as defined above, (1) -COR9, wherein R9 is as defined above, and (m) -C02R9, wherein R9 is as defined above; (3) (4) C2-6 alkynyl; (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) Cl-6 alkoxy, (c) Cl-6 alkyl, (d) C2-5 alkenyl, (e) halo, (f) -CN, (g) -Nθ2, ( ) -CF3, (i) -(CH2)m-NR9R 10, wherein m, R9 and RlO are as defined above, (j) -NR9COR10, wherein R9 and RlO are as defined above, (k) -NR9C02R 10, wherein R9 and R 10 are as defined above, (1) -CONR9R10, wherein R9 and RlO are as defined above, (m) -CO2NR9R10, wherein R9 and RlO are as defined above, (n) -COR9, wherein R9 is as defined above; - (o) -C02R9, wherein R9 is as defined above; and the groups Rl and R2 may be joined together to form a heterocyclic ring selected from the group consisting of: (a) pyrrolidinyl, (b) piperidinyl, (c) pyrrolyl, (d) pyridinyl, (e) . imidazolyl, (f) oxazolyl, and (g) thiazolyl, and wherein the heterocyclic ring is unsubstituted or . . substituted with one or more substituent(s) selected from: (i) Cl-6alkyl, (ii) oxo, (iii) Cl-6alkoxy, (iv) -NR9R10, wherein R9 and RlO are as defined above, (v) halo, and (vi) trifluoromethyl; and the groups R2 and R3 may be joined together to form a carbocychc ring selected from the group consisting of: (a) cyclopentyl, (b) cyclohexyl, (c) phenyl, and wherein the carbocyclic ring is unsubstituted or substituted with one or more substituents selected from: (i) Cl-6alkyl, and wherein the heterocyclic ring is unsubstituted or substituted with one or more substituent(s) selected from: (i) Cl-6alkyl, (ii) oxo, (iii) Cl-6alkoxy, (iv) -NR9R10, wherein R9 and RlO are as defined above, (v) halo, and (vi) trifluoromethyl; X is selected from the group consisting of: (1) -o-, (2) -S-, (3) -SO-, and (4) -Sθ2-; R6, R7 and R8 are independently selected from the group consisting of: (1) hydrogen; (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR9R10, wherein R9 and RlO are as defined above, (i) -NR9COR10, wherein R9 and RlO are as defined above, (j) -NR9CO2R10, wherein R9 and RlO are as defined above, (k) -CONR9R 10, wherein R9 and RlO are as def ed above, (1) -COR9, wherein R9 is as defined above, and (m) -C02R9, wherein R9 is as defined above; (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR9R10 wherein R9 and RlO are as defined above, (i) -COR9 wherein R9 is as defined above, (j) -C02R9, wherein R9 is as defined above; (4) C2-6 alkynyl; (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) Cl-6 alkoxy, (c) Cl-6 alkyl, (d) C2-5 alkenyl, - (e) halo, (f) -CN, (g) -Nθ2, ( ) -CF 3 , (i) -(CH2)m-NR9R 10, wherein m, R9 and RlO are as defined above, (j) -NR9COR10, wherein R9 and RlO are as defined above, (k) -NR9C02R 10 , wherein R9 and RlO are as defined above, (1) -CONR9R10, wherein R9 and RlO are as defined above, (m) -CO2NR9R10, wherein R9 and RlO are as defined above, (n) -COR9, wherein R9 is as defined above; (o) -C02R9, wherein R9 is as defined above; (6) halo, (7) -CN, (8) -CF3, (9) -N02, (10 -SR14, wherein Rl4 is hydrogen or Cl-5alkyl, (11 -SOR14, wherein Rl4 is as defined above, (12 -Sθ2R , wherein Rl4 is as defined above, (13 NR9COR10, wherein R9 and RlO are as defined above, (14 CONR9COR10, wherein R9 and RlO are as defined above, (15 NR9R10, wherein R9 and RlO are as defined above, (16 NR9C02R10, wherein R9 and RlO are as defined above, (17 hydroxy, (18 Cl-6alkoxy, (19 COR9, wherein R9 is as defined above, (20 C02R9, wherein R9 is as defined above, (21 2-ρyridyl, (22 3 -pyridyl, (23 4-pyridyl, (24 5-tetrazolyl, (25 2-oxazolyl, and (26 2-thiazolyl; Rl l, Rl2 and Rl3 are independently selected from the definitions of R6, R7 and R8; (b) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (i) hydroxy, (ii) Cl-6 alkoxy, (iii) Cl-6 alkyl, (iv) C2-5 alkenyl, (v) halo, (vi) -CN, (vii) -N02, (viii) -CF3, (ix) -(CH2)m-NR9RlO, wherein m, R9 and RlO are as defined above, (x) -NR9COR 10, wherein R9 and RlO are as defined above, (xi) -NR9C02R 10, wherein R9 and RlO are as defined above, (xii) -CONR9R10, wherein R9 and RlO are as defined above, (xiii) -CO2NR9R10, wherein R9 and RlO are as defined above, (xiv) -COR9, wherein R9 is as defined above, and (xv) -C02R9, wherein R9 is as defined above; Z is Cl-6 alkyl; which comprises contacting a compound of formula V: wherein Rl, R2, R3, R6, R7, R8, Rl 1 , Rl2 and Rl3 are as defined above; with an inorganic or an organic acid selected from the group consisting of: toluenesulfonic acid, methanesulfonic acid, sulfuric acid, hydrochloric acid and mixtures thereof, in an aprotic solvent selected from the group consisting of: toluene, benzene, dimethylformamide, tetrahydrofuran, diethylether, dimethoxyethane, ethyl acetate, and mixtures thereof, at a temperature from 0°C to solvent reflux temperature for a sufficient time to produce a compound of structural formula IV. 25. A process for the preparation of a compound of structural formula XI: XI or a pharmaceutically acceptable salt thereof, wherein: Rl is selected from the group consisting of: (1) hydrogen; (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b). oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -NR9R10, wherein R9 and RlO are independently selected from: (i) hydrogen, (ii) Cl-6 alkyl, (iii) hydroxy-Ci-6 alkyl, and (iv) phenyl, (i) -NR9COR10, wherein R9 and RlO are as defined above, (j) -NR9C02R!0, wherein R9 and RlO are as defined above, (k) -CONR9R 10, wherein R9 and RlO are as defined above, (1) -COR9, wherein R is as defined above, (m) -C02R9, wherein R9 is as defined above; (n) heterocycle, wherein the heterocycle is selected from the group consisting of: (A) benzimidazolyl, (B) benzofuranyl, (C) benzothiophenyl, 10 (D) benzoxazolyl, (E) furanyl, (F) imidazolyl, (G) indolyl, (H) isooxazolyl, 15 (I) isothiazolyl, (J) oxadiazolyl, (K) oxazolyl, (L) pyrazinyl, (M) pyrazolyl, 20 (N) pyridyl, (O) pyrimidyl, (P) pyrrolyl, (Q) quinolyl, (R) tetrazolyl, 25 (S) thiadiazolyl, (T) thiazolyl, (U) thienyl, (V) triazolyl, (W) azetidinyl, 30 (X) 1,4-dioxanyl, (Y) hexahydroazepinyl, (Z) piperazinyl, (AA) piperidinyl, (AB) pyrrolidinyl, (AC) tetrahydrofuranyl, and (AD) tetrahydrothienyl, and wherein the heterocycle is unsubstituted or substituted with one or more substituent(s) selected from: (i) Cl-6 alkyl, unsubstituted or substituted with halo, -CF3, -OCH3, or phenyl, (ii) Cl-6 alkoxy, (iii) oxo, (iv) hydroxy, (v) thioxo, (vi) -SR9, wherein R9 is as defined above, (vii) halo, (viii) cyano, (ix) phenyl, (x) trifluoromethyl, (xi) -(CH2)m-NR9RlO, wherein m is 0, 1 or 2, and R9 and RlO are as defined above, (xii) -NR9COR10, wherein R9 and RlO are as defined above, (xiii) -CONR9R10, wherein R9 and RlO are as defined above, (xiv) -C02R9, wherein R9 is as defined above, and (xv) -(CH2)m-OR9, wherein m and R9 are as defined above; (3) C2-6 alkenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (f) -CN, (g) halo, (h) -CONR9R10 wherein R9 and RlO are as defined above, (i) -COR9 wherein R9 is as defined above, (j) -C02R9, wherein R9 is as defined above, (k) heterocycle, wherein the heterocycle is as defined above; (4) C2-6 alkynyl; (5) phenyl, unsubstituted or substituted with one or more of the substituent(s) selected from: (a) hydroxy, (b) Cl-6 alkoxy, (c) Cl-6 alkyl, (d) C2-5 alkenyl, (e) halo, (f) -CN, (g) -Nθ2, (h) -CF3, (i) -(CH2)m-NR9R 10, wherein m, R9 and Rl 0 are as defined above, ) -NR9COR 10, wherein R9 and R 10 are as defined above, (k) -NR9C02R 1 °, wherein R9 and R 10 are as defined above, (1) -CONR9R 10, wherein R9 and R 10 are as defined above, (m) -CO2NR9R10, wherein R9 and RlO are as defined above, (n) -COR9, wherein R9 is as defined above; (o) -C02R9, wherein R9 is as defined above; R3 are independently selected from the group consisting of: (1) hydrogen, (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (v) halo, and (vi) trifluoromethyl; R6, R7 and R8 are independently selected from the group consisting of: (1) hydrogen; (2) Cl-6 alkyl, unsubstituted or substituted with one or more of the substituents selected from: (a) hydroxy, (b) oxo, (c) Cl-6 alkoxy, (d) phenyl-Cl-3 alkoxy, (e) phenyl, (0 -CN, (g) halo, (h) -NR9R10, wherein R9 and RlO are as defined above, (i) -NR9COR10, wherein R9 and RlO are as defined above, (j) -NR9CO2R10, wherein R9 and RlO are as defined above, (k) -CONR9R 10, wherein R9 and RlO are as defined above, (1) -COR9, wherein R9 is as defined above, and (m) -C02R9, wherein R9 is as defined above; (3) (12) -S02R14, wherein Rl4 is as defined above, (13 NR9COR10, wherein R9 and RlO are as defined above, (14 CONR9COR10, wherein R9 and RlO are as defined above, (15 NR9R10, wherein R9 and RlO are as defined above, (16 NR9Cθ2R O, wherein R9 and RlO are as defined above, (17 hydroxy, (18 Cl-6alkoxy, (19 COR9, wherein R9 is as defined above, (20 C02R9, wherein R9 is as defined above, (21 2-pyridyl, (22 3 -pyridyl, (23 4-pyridyl, (24 5-tetrazolyl, (25 2-oxazolyl, and (26 2-thiazolyl; Rl l, Rl2 and Rl3 are independently selected from the definitions of R6, R7 and R8; Z is Cl-6 alkyl; which comprises contacting a compound of formula IX: IX wherein Rl, R^, R3, Rl 1, Rl2 and Rl are defined as above; with a hydride reducing agent selected from a group consisting of: diisobutylaluminum hydride: lithium tri(sec-butyl)borohydride: and lithium aluminum hydride; in an organic solvent at low temperature; followed by acylation of the resultant alcohol/alkoxide with a substituted benzoyl halide, substituted benzoic anhydride, substituted benzoic mixed anhydride or substituted activated benzoate ester (e.g. p-nitrophenyl ester or N-hydroxysuccinimide ester), in which the phenyl ring of these acylating agents is substituted with R , R7, and R as defined above, in an organic solvent at low temperature for a sufficient time to produce a compound of structural formula X: X and subsequently contacting the compound of formula X with a titanium ylide (generated from reagents selected from: μ-chloro-μ-methylene- (bis(cyclopentadienyl)titanium)dimethylamluminum; or dimethyl titanocene; or the reagent prepared by the reduction of a 1,1- dibromoalkane with zinc and titanium tetrachloride in the presence of N,N,N',N'-tetramethylethylenediamine) to afford an. enol ether which is then hydrogenated in the presence of a a catalyst selected from palladium on carbon, platinum on carbon, or rhodium on carbon to afford the compound of formula XI.

Inventors: CHAMBERS MARK STUART, DORN CONRAD P, FINKE PAUL E, HALE JEFFREY J, HARRISON TIMOTHY, LADDUWAHETTY TAMARA, MACCOSS MALCOLM, MILLS SANDER G, SHAH SHRENIK K, WILLIAMS BRIAN JOHN, CHAMBERS, MARK, STUART, DORN, CONRAD, P., FINKE, PAUL, E., HALE, JEFFREY, J., HARRISON, TIMOTHY, LADDUWAHETTY, TAMARA, MACCOSS, MALCOLM, MILLS, SANDER, G., SHAH, SHRENIK, K., WILLIAMS, BRIAN, JOHN
Applicants: CHAMBERS MARK STUART, DORN CONRAD P, FINKE PAUL E, HALE JEFFREY J, HARRISON TIMOTHY, LADDUWAHETTY TAMARA, MACCOSS MALCOLM, MERCK & CO INC, MILLS SANDER G, SHAH SHRENIK K, WILLIAMS BRIAN JOHN, CHAMBERS, MARK, STUART, DORN, CONRAD, P., FINKE, PAUL, E., HALE, JEFFREY, J., HARRISON, TIMOTHY, LADDUWAHETTY, TAMARA, MACCOSS, MALCOLM, MERCK & CO., INC., MILLS, SANDER, G., SHAH, SHRENIK, K., WILLIAMS, BRIAN, JOHN
Application year: 1994
Main classification: C07D265
IPC codes: A61K31, A61P1, A61P9, A61P11, A61P25, A61P29, A61P37, C07D265, C07D279, C07D413, C07D417