Processes for producing optically active 2-amino-1-phenylethanol derivatives

Abstract: A process is provided for producing an (R)-2-amino-1-phenylethanol derivative which comprises permitting certain selected strains of micro-organisms capable of acting on a compound shown by the general formula (VII) wherein R 1 -R 5 represent a hydrogen atom etc, to produce a corresponding (R)-2-amino-1-phenylethanol compound of formula (IIa) to act on said compound or source thereof and harvesting or recovering the product optically active compound or a salt thereof.

Description: FIELD OF THE INVENTION The present invention relates to processes for producing 2-amino-1-phenylethanol derivatives and optically active enantiomers thereof which are important intermediates for synthesis of (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivatives. The present invention further relates to processes for producing the (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino] ethanol derivatives which are useful as medical compounds or intermediate products thereof. BACKGROUND OF THE INVENTION As anti-obesity agents or anti-diabetic agents belonging to a new category of agents without using insulin, 1-phenyl-2-(2-phenyl-1-alkylethyl)amino] ethanol derivatives are noted since the derivatives act selectively on a β 3 -receptor in vivo , thus having extremely low side effects. Pharmacological studies on the 1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivatives have revealed that the β 3 -action substantially depends on (R,R)-form thereof (see J. Med. Chem., 35 , 3081 (1992), and U.S. Patent 5,061,727). For example, the above-mentioned U.S. Patent discloses that an (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt has a higher activity than the corresponding (S,S)-form by a factor of 47. For the production of an optically active 1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative, there is known an optical resolution of a racemic form or a racemate, or an asymmetric synthesis. For example, Japanese Patent Application Laid-open No. 320153/1993 (JP-A-5-320153) corresponding to the above mentioned U.S. Patent 5,061,727, U.S. Patent 5,106,867 and Japanese Patent Application Laid-open No. 18340/1983 (JP-A-58-18340) disclose a method of producing an (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino] ethanol derivative which comprises (1) allowing a racemic phenylethanol derivative to react with a phenylacetone derivative and a reducing agent such as sodium cyanoborohydride to produce a mixture of four species of optical isomers of a 1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative, (2) isolating and removing an (R,S)-isomer and an (S,R)-isomer from the mixture, and (3) optically resoluting an (R,R)-isomer and an (S,S)-isomer by a diastereomer method. According to the method, however, it is necessary to isolate and purify the only (R,R)-isomer from a mixture of the four species of optical isomers, therefore, the processes are complicated and the yield is decreased. Further, since large quantities of raw materials are required, the method is also disadvantageous in economical factors. The U.S. Patents and the Journal of Medicinal Chemistry as mentioned above disclose a method allowing an (R)-3-chlorostyrene oxide derivative to react with an (R)-1-methyl-2-phenylethylamine derivative. The (R)-1-methyl-2-phenylethylamine derivative used as a raw material or reactant in the method, however, has a strong antihypnotic or arousal action and it requires a particular attention when handled, therefore is not suited for a use in commercial production. Further, a lot of steps or processes are required to obtain the above-mentioned (R)-1-methyl-2-phenylethylamine derivative. For example, the (R)-methyl-2-phenylethylamine derivative is prepared from L-DOPA through six steps, namely, introduction of a protective group into an amino group, esterification, reduction of the resulting ester, converting a hydroxyl group to a mesyloxy group, deprotection of the protective group and reduction. On the other hand, as a method of producing an optically active 2-amino-1-phenylethanol derivative used as a raw material or a reactant for the 1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative in the present invention, there is known a method of optical resolution of a corresponding racemic form with the use of an optically resoluting agent. Japanese Patent Application Laid-open No. 9979/1989 (JP-A-64-9979) [Japanese Patent Publication No. 48791/1992 (JP-B-4-48791)], for instance, discloses a method of optically resoluting a racemic 2-amino-1-(3-chlorophenyl)ethanol with N-(t-butoxycarbonyl)-D-alanine to obtain an optically active (R)-form. Further, Japanese Patent Application Laid-open No. 85247/1990 (JP-A-2-85247) discloses a method of optically resoluting a racemic 2-amino-1-(4-chlorophenyl) ethanol with using D-tartaric acid. Moreover, Journal of Japan Chemical Society, 1985, (5), pp. 910 to 913 discloses a method of optically resoluting a racemic 2-amino-1-phenylethanol with employing 3-aminobenzoic acid as a optically resoluting agent. According to these methods, however, the object optically active 2-amino-1-phenylethanol derivative can not be produced expediently and efficiently since the racemic 2-amino-1-phenylethanol derivative to be subjected to the optical resolution can not be obtained in a simple and easy manner with good yield. For instance, as a method of producing the 2-amino-1-phenylethanol derivative, a method of reducing a nitrogen-containing compound, and a method utilizing an addition reaction of ammonia are known. As examples of the method of reducing a nitrogen-containing compound, there are known (a) a method of reducing mandelonitrile [see J. Org. Chem., 45 (14), 2785 (1980), Japanese Patent Application Laid-open No. 27/1971 (JP-A-46-27) and the like], (b) a method of reducing mandelic acid amide [refer to J. Appl. Chem., 1 (1951), 469] and (c) a method of reducing a nitro compound [see Coll. Czech. Chem. Comm., 43 (7), 1917 (1978)]. In the method (a), however, since mandelonitrile is instable, the hydroxyl group is required to be protected to obtain the object compound with high yield. Further, the reaction is conducted in the presence of a great amount of a reducing agent such as LiAlH 4 and NaBH 4 and an activating catalyst, thus the method is disadvantageous in economical factors and requires attention to be handled. Moreover, the purity of the obtained 2-amino-1-phenylethanol derivative is low of about 95%. In the methods (b) and (c), since a large quantity of LiAlH 4 and the like is used as the reducing agent, there are problems similar thereto. According to the method (c) where nitromethane is employed as a solvent it is highly dangerous and needs a sufficient care when handled. As the method utilizing an addition reaction of ammonia, there is known (d) a method of allowing an epoxy compound to react with ammonia (see Syn. Com., 3 (3), 177, (1973), and (e) a method of allowing a halohydrin compound to react with ammonia [refer Indian. J. Chem., SECT. B, 31B , 821 (1992)]. Although the reaction procedures are expedient, in these methods, however, a 1-amino-2-phenylethanol derivative as a position isomer of the 2-amino-1-phenylethanol derivative is liable to be by-produced. The position-isomer can hardly be removed by an isolating and purifying process generally used such as distillation, recrystallization and extraction, therefore, complicated procedures such as column purification are required. On the other hand, a method of obtaining an optically active 2-amino-1-phenylethanol with the use of a microorganism is known. That is, Chemistry Express, 4 , 9, 621 to 624 (1989) discloses microorganisms belonging to the genus Staphylococcus , the genus Micrococcus , the genus Rhodococcus and the genus Neisseria produce, respectively, an optically active 2-amino-1-phenylethanol from 2-amino-1-phenylethanol and α-aminoacetophenone. SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide a process for efficiently producing an optically active (R)-2-amino-1-phenylethanol derivative, which is useful for the efficient production of an (R,R)-1-phenyl-2-[(2-Phenyl-1-alkylethyl)amino] ethanol derivative with a good yield, with high yield and optical purity. It is another object of the present invention to provide a process of producing efficiently the optically active compound, which is useful for the production of the (R,R)-isomer and is available and easy to handle or treat, with high optical purity. A yet another object of the present invention is to provide a process whereby a 2-amino-1-phenylethanol derivative which is useful for obtaining the optically active compound efficiently can be obtained in an expedient manner with good yield and high purity. Still another object of the present invention is to provide a process for producing an (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative having a higher optical purity efficiently with high yield. A further object of the invention is to provide a process for producing an (S)-form, which is useful for production of the optically active compound, efficiently with good yield. The present invention further relates to a process for asymmetrically reducing an aminoketone compound to the optically active compound, and to a use of a microorganism in production of the optically active compounds. After much studies and efforts to accomplish the above mentioned objects, the present inventors found (i) that an optically active (R)-or (S)-2-amino-1-phenylethanol derivative having high optical purity can be obtained efficiently by a method with the aid of a specific microorganism, and (ii) that an optically active (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative can easily or readily be produced by a reaction of the (R)-form with a phenylacetone derivative, and a reducing reaction of the reaction product of the above reaction with high yield, high optical purity and selectivity. The present invention has been accomplished based on the above findings. Thus, the present invention provides a process for producing an (R)-2-amino- 1-phenylethanol derivative which comprises: permitting a microorganism which is capable of acting on a compound shown by the general formula (VII) wherein R 1 , R 2 , R 3 , R 4 and R 5 have the same meanings as defined above, or a salt thereof to produce a corresponding optically active compound shown by the general formula (IIa) or a salt thereof, to act on the compound or a salt thereof and harvesting or recovering the product optically active compound of the general formula (IIa) or a salt thereof: wherein R 1 , R 2 , R 3 , R 4 and R 5 represent, the same or different, a hydrogen atom, a halogen atom, an optionally substituted C 1 -C 4 alkyl group, a hydroxyl group which may be protected with a protective group, an optionally substituted alkoxy group, an optionally substituted cycloalkyloxy group, an optionally substituted aralkyloxy group, an optionally substituted aryloxy group, an optionally substituted C 1 -C 4 alkylthio group, an optionally substituted acyl group, a carboxyl group which may be protected with a protective group, an optionally substituted C 1 -C 4 alkoxycarbonyl group, a nitro group, an optionally substituted amino group, or a salt thereof. The optically active compound of the general formula (IIa) or a salt thereof is useful for an intermediate for production of an (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino] ethanol derivative. The present invention further provides a process for producing an (R, R) -1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative shown by the general formula (XI) wherein R 1 , R 2 , R 3 , R 4 and R 5 have the same meanings as defined above; R 7 and R 8 represent; (A) respectively, a group selected from the group consisting of a hydrogen atom, an optionally substituted C 1 -C 4 alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aralkyl group, an optionally substituted aryl group, an optionally substituted acyl group, a carboxyl group which may be protected with a protective group, an optionally substituted C 2 -C 5 alkoxycarbonyl group, an optionally substituted amino group, an optionally substituted alkylsulfonyl group, an optionally substituted arylsulfonyl group and a hydroxyl group which may be protected with a protective group, or (B) R 7 represents a group shown by the formula (IX): -O-R 7a and R 8 represents a group shown by the formula (X): -O-R 8a wherein R 7a and R 8a may form an optionally substituted ring with the adjacent oxygen atoms; R 6 , R 9 and R 10 independently represent a group selected from a group consisting of a hydrogen atom, a halogen atom, an optionally substituted C 1 -C 4 alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aralkyl group, an optionally substituted aryl group, a hydroxyl group which may be substituted with a protective group, an optionally substituted alkoxy group, an optionally substituted cycloalkyloxy group, an optionally substituted aralkyloxy group, an optionally substituted aryloxy group, an optionally substituted C 1 -C 4 alkylthio group, an optionally substituted aralkylthio group, an optionally substituted acyl group, a carboxyl group which may be protected with a protective group, an optionally substituted C 2 -C 5 alkoxycarbonyl group, a nitro group and an optionally substituted amino group; R 11 represents a C 1 -C 4 alkyl group, which comprises: a reaction of an (R)-2-amino-1-phenylethanol compound shown by the general formula (II) wherein R 1 , R 2 , R 3 , R 4 , R 5 and Z have the same meanings as defined above, or a salt thereof, with a compound shown by the general formula (VIII) wherein R 6 , R 7 , R 8 , R 9 , R 10 and R 11 have the same meanings as defined above, or a salt thereof, and a reducing reaction of the reaction product of the reaction. Further, an (S)-form or a salt thereof corresponding to the (R)-form of the general formula (IIa) can be obtained by, for example, a process which comprises: permitting a microorganism or a preparation thereof which is capable of acting on the compound shown by the general formula (VII) or a salt thereof to produce the corresponding optically active compound of the formula (XV) or a salt thereof, to act on said compound or a salt thereof, and harvesting or recovering the product optically active compound of the general formula (XV) or a salt thereof: wherein R 1 , R 2 , R 3 , R 4 and R 5 have the same meanings as defined above, or a salt thereof. The present invention still further discloses a process for asymmetrically reducing the aminoketone compound of the general formula (VII) to the corresponding (R)- or (S)-2-amino-1-phenylethanol derivative, a use of a microorganism or a preparation thereof for the production of the (R)- or (S)-form or a salt thereof. DETAILED DESCRIPTION OF THE INVENTION As the halogen atom in R 1 , R 2 , R 3 , R 4 and R 5 in the general formula (II), (IIa) or the like, there may be mentioned fluorine atom, chorine atom, bromine atom and iodine atom. The optionally substituted lower alkyl group includes, for example, (a) an optionally substituted alkyl group having 1 to 4 carbon atoms (for instance, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, s-butyl and t-butyl groups). Examples of the substituent(s) for the C 1-4 alkyl group includes a hydroxyl group, a C 1-4 alkoxy group, a benzoyl group, a C 6-12 aryl group (e.g. phenyl group) which may be substituted with a substituent (for example, a C 1-4 alkoxy group, etc.), a C 1-4 alkylthio group and a halogen atom. As examples of such substituted C 1-4 alkyl group, there may be mentioned (b) a C 1-4 alkyl group substituted with hydroxyl group(s) (for example, hydroxymethyl, 2-hydroxyethyl, 1,2-dihydroxyethyl, 2,2-dihydroxyethyl, 3,3-dihydroxypropyl group, etc.), (c) a C 1-4 alkoxy-C 1-4 alkyl group (for instance, methoxymethyl, ethoxymethyl, t-butoxymethyl, 1-ethoxyethyl, 2-methoxyethyl group, etc.), (d) phenacyl group, (e) a C 1-4 alkylthio-C 1-4 alkyl group (e.g. a C 1-4 alkylthiomethyl such as methylthiomethyl, ethylthiomethyl group, etc.), (f) a C 1-4 haloalkyl group having 1 or more of halogen atoms such as chloromethyl, 2-chloroethyl, 3-chloropropyl, 4-chlorobutyl, dichloromethyl, trichloromethyl, trifluoromethyl, 2,2,2-trichloroethyl, 2,2,2-trifluoroethyl, 1,1,2,2,2-pentafluoroethyl, and other groups. As the protective group for hydroxyl group, there may be mentioned protective groups for a hydroxyl group generally employed in the field of organic synthesis. Such protective groups include, for example, (A) a group which forms an ether bond with an oxygen atom, (B) a group which forms an ester bond with an oxygen atom, (C) a group which forms a carbonate with an oxygen atom and (D) a group which forms a sulfonic acid ester with an oxygen atom. Examples of the group (A) which forms an ether bond with an oxygen atom include (1) an optionally substituted lower alkyl group, (2) an optionally substituted allyl group, (3) an optionally substituted cycloalkyl group, (4) an optionally substituted heterocyclic group, (5) an optionally substituted aralkyl group and (6) an optionally substituted silyl group. The optionally substituted lower alkyl group (1) includes, for example, (a) an optionally substituted alkyl group having 1 to 4 carbon atoms such as methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl and t-butyl groups. The substituents for the C 1-4 alkyl group include, for example, a C 1-4 alkoxy group, a C 1-4 alkoxy-C 1-4 alkoxy group, a C 7-20 aralkyloxy group, a benzoyl group, a C 1-4 alkylthio group, a halogen atom and so on. Examples of such substituted C 1-4 alkyl group include (b) a C 1-4 alkoxy-C 1-4 alkyl group such as methoxymethyl, ethoxymethyl, t-butoxymethyl, 1-methoxyethyl, 1-ethoxyethyl, 2-methoxyethyl (especially a C 1-4 alkoxy-C 1-2 alkyl group); (c) a C 1-4 alkoxy-C 1-4 alkoxy-C 1-4 alkyl group such as 2-methoxyethoxymethyl, 2-ethoxymethoxymethyl and the like (specifically a C 1-4 alkoxy-C 1-4 alkoxy-C 1-2 alkyl group); (d) a C 7-20 aralkyloxy-C 1-4 alkyl group such as benzyloxymethyl (especially, a C 7-20 aralkyloxymethyl group); (e) a phenacyl group; (f) a C 1-4 alkylthio-C 1-4 alkyl group such as methylthiomethyl, ethylthiomethyl (specifically a C 1-4 alkylthiomethyl group); and (g) a C 1-4 haloalkyl group having one or more of halogen atoms such as trichloromethyl, trifluoromethyl, 2,2,2-trichloroethyl, 2,2,2-trifluoroethyl and the like. As the substituent for the allyl group (2) include, for instance, substituents for the C 1-4 alkyl group mentioned in the above (1). Examples of the optionally substituted cycloalkyl group (3) include a cycloalkyl group having 3 to 10 carbon atoms such as cyclopropyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl and cyclodecyl groups. The substituent(s) for the cycloalkyl group include, for example, a halogen atom, a C 1-4 alkyl group, and a hydroxyl group. As the optionally substituted heterocyclic group (4), there may be mentioned, for example, an optionally substituted 5- or 6-membered heterocyclic group having, other than carbon atoms, an oxygen atom or a sulfur atom as a hetero atom. The optionally substituted heterocyclic group may frequently be a non-aromatic perhydroheterocyclic group. The 5- or 6-membered heterocyclic group includes, for instance, tetrahydrofuranyl, tetrahydrothiofuranyl, tetrahydropyranyl and tetrahydrothiopyranyl groups. Examples of the substituents for the heterocyclic group include a halogen atom, a C 1-4 alkyl group, a C 1-4 alkoxy group such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, s-butoxy and t-butoxy, and substituents as mentioned above in lower alkyl group (1). Practical examples of the optionally substituted heterocyclic group include an optionally substituted tetrahydropyranyl group (e.g. tetrahydropyranyl, 3-bromotetrahydropyranyl, 4-methoxytetrahydropyranyl, etc.), an optionally substituted tetrahydrothiopyranyl group (for example, tetrahydrothiopyranyl, 3-bromotetrahydrothiopyranyl, 4-methoxytetrahydrothiopyranyl, etc.), an optionally substituted tetrahydrofuranyl group (for instance, tetrahydrofuranyl, etc.), and an optionally substituted tetrahydrothiofuranyl group (e.g. tetrahydrothiofuranyl). Examples of the optionally substituted aralkyl group (5) include an optionally substituted aralkyl group having 7 to 20 carbon atoms (e.g. benzyl, etc.). The substituent for the aralkyl group includes, for instance, a C 1-4 alkyl group; a C 6-12 aryl group such as phenyl group; a hydroxyl group, a C 1-4 alkoxy group; a nitro group; and a halogen atom. Examples of such substituent may be referred to those in the above group (4). Typical examples of the optionally substituted aralkyl group include benzyl, o-chlorobenzyl, o-nitrobenzyl, p-chlorobenzyl, p-methoxybenzyl, p-methylbenzyl, p-nitrobenzyl, 2,6-dichlorobenzyl, diphenylmethyl, trityl and the like. The substituent for the silyl group (6) includes a C 7-20 aralkyl group such as benzyl group and substituents as mentioned in the aralkyl group (5). Examples of the optionally substituted silyl group (6) include trimethylsilyl, triethylsilyl, t-butyldimethylsilyl, tribenzylsilyl, triphenylsilyl and so on. As the group (B) which forms an ester bond with an oxygen atom, there may be mentioned, for example, an optionally substituted acyl group including (1) an acyl group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, a C 1-4 alkoxy group, C 1-4 alkylthio group, a halogen atom and the like (for instance, formyl, acetyl, chloroacetyl, trifluoroacetyl, propionyl, isopropionyl, butyryl, isobutyryl, valeryl, isovaleryl, pivaloyl and the like); (2) a C 7-16 acyl group having an aromatic ring which may be substituted with, for example, a C 1-4 alkyl group, a hydroxyl group, a C 1-4 alkoxy group, a nitro group or a halogen atom (e.g. benzoyl, p-phenylbenzoyl, toluoyl, naphthoyl and others); (3) an acyl group having a heterocyclic ring (e.g. furoyl, thenoyl, nicotinoyl and isonicotinoyl groups) which may be substituted with, for instance, a C 1-4 alkyl group, a hydroxyl group, a C 1-4 alkoxy group, a nitro group or a halogen atom. The group (C) which forms a carbonate with an oxygen atom includes, for instance, (1) a C 2-5 alkoxycarbonyl group such as methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, s-butoxycarbonyl and t-butoxycarbonyl which may be substituted with, for example, a C 1-4 alkoxy group which may be substituted with a C 1-4 alkoxy group; a C 7-20 aralkyloxy group; benzoyl group; a C 1-4 alkylthio group; or a halogen atom; (2) a C 8-20 aralkyloxycarbonyl group such as benzyloxycarbonyl, p-methoxybenzyloxycarbonyl, p-methylbenzyloxycarbonyl, p-chlorobenzyloxycarbonyl, o-nitrobenzyloxycarbonyl, etc. which may be substituted with a C 1-4 alkyl group, a hydroxyl group, a C 1-4 alkoxy group, a nitro group, a halogen atom, etc., (3) a C 7-20 aryloxycarbonyl group which may be substituted with a C 1-4 alkyl group, a hydroxyl group, a C 1-4 alkoxy group, a nitro group, a halogen atom, etc., such as phenoxycarbonyl, 4-methylphenyloxycarbonyl, 4-nitrophenyloxycarbonyl, 4-chlorophenyloxycarbonyl, naphthyloxycarbonyl and so on. Examples of the group (D) which forms a sulfonic acid ester with an oxygen atom include, for instance, (1) an alkylsulfonyl group such as a C 1-4 alkylsulfonyl group which may be substituted with, for instance, a C 1-4 alkoxy group, a C 1-4 alkoxy-C 1-4 alkoxy group, a C 7-20 aralkyloxy group, a benzoyl group, a C 1-4 alkylthio group and a halogen atom (e.g. methanesulfonyl, ethanesulfonyl, propanesulfonyl, butanesulfonyl, trichloromethanesulfonyl, trifluoromethanesulfonyl, etc.); (2) an optionally substituted arylsulfonyl group including a C 6-20 arylsulfonyl group which may be substituted with, for example, a C 1-4 alkyl group, a hydroxyl group, a C 1-4 alkoxy group, a nitro group or a halogen atom such as benzenesulfonyl, m-nitrobenzenesulfonyl, p-nitrobenzenesulfonyl, p-chlorobenzenesulfonyl, p-bromobenzenesulfonyl, p-toluenesulfonyl, naphthalenesulfonyl and others. The optionally substituted alkoxy group includes, for instance, an optionally substituted alkoxy group having 1-4 carbon atoms (e.g. methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, s-butoxy, or t-butoxy group) and others. Examples of the substituent for the alkoxy group include a hydroxyl group, a C 1-4 alkoxy group, a halogen atom and the like. As the substituted alkoxy group, there may be mentioned, for example, a hydroxy-C 1-4 alkoxy group such as hydroxymethoxy, 2-hydroxyethoxy, 1,2-dihydroxyethoxy, 2,2-dihydroxyethoxy, and 3,3-dipropoxyethoxy groups; a C 1-4 alkoxy-C 1-4 alkoxy group such as methoxymethoxy, ethoxymethoxy, 1-ethoxyethoxy, and other groups. The substituent for the cycloalkyloxy group include, for instance, a halogen atom, a C 1-4 alkyl group, a hydroxyl group and the like. Examples of the cycloalkyloxy group include a C 3-10 cycloalkyloxy group such as cyclopropyloxy, cyclobutyloxy, cyclopentyloxy, cyclohexyloxy, cycloheptyloxy, cyclooctyloxy, cyclononyloxy and cyclodecyloxy groups. The optionally substituted aralkyloxy group include a C 7-20 aralkyloxy group which may be substituted with, for examples, a C 1-4 alkyl group, a C 6-12 aryl group, a hydroxyl group, a C 1-4 alkoxy group, a nitro group, or a halogen atom as exemplified above, such as benzyloxy, m-bromobenzyloxy, m-chlorobenzyloxy and other groups. Examples of the optionally substituted aryloxy group include a C 6-16 aryloxy group such as phenoxy group. The substituents for the aryloxy group include, for instance, a C 1-4 alkyl group, a hydroxyl group, a C 1-4 alkoxy group, a nitro group, a halogen atom as exemplified above. As the lower alkylthio group, there may be mentioned, for example, a C 1-4 alkylthio group such as methylthio, ethylthio, propylthio, isopropylthio, butylthio, isobutylthio, s-butylthio, t-butylthio, and other groups. The substituent for the lower alkylthio group include, for instance, a hydroxyl group, a C 1-4 alkoxy group, a halogen atom and so on. Examples of the optionally substituted acyl group include (1) an acyl group having 1 to 6 carbon atoms which may be substituted with a halogen atom, a hydroxyl group, a C 1-4 alkoxy group, C 1-4 alkylthio group (for instance, formyl, acetyl, chloroacetyl, trifluoroacetyl, propionyl, isopropionyl, butyryl, isobutyryl, valeryl, isovaleryl, pivaloyl and the like); (2) a C 7-16 acyl group having an aromatic ring which may be substituted with, for example, a C 1-4 alkyl group, a hydroxyl group, a C 1-4 alkoxy group, a nitro group or a halogen atom (e.g. benzoyl, p-phenylbenzoyl, toluoyl, naphthoyl and others); (3) an acyl group having a heterocyclic ring which may be substituted with, for instance, a C 1-4 alkyl group, a hydroxyl group, a C 1-4 alkoxy group, a nitro group or a halogen atom (e.g. furoyl, thenoyl, nicotinoyl and isonicotinoyl groups). The protective group for carboxyl group includes, for instance, an optionally substituted C 1-4 alkyl group, an optionally substituted C 6-16 aryl group, an optionally substituted C 7-20 aralkyl group, an optionally substituted amino group. As the optionally substituted C 1-4 alkyl group, etc., there may be mentioned the optionally substituted alkyl group, etc., as exemplified above. The optionally substituted amino group include an optionally substituted amino group as mentioned just hereinbelow as well as an amino group substituted with a C 7-20 aralkyl group. Practical examples of the protected carboxyl group include (a) a C 1-4 alkoxy-carbonyl group which may be substituted with, for example, a hydroxyl group, a C 1-4 alkoxy group, etc. (for instance, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, butoxycarbonyl, t-butoxycarbonyl, methoxymethoxycarbonyl, methoxyethoxy carbonyl group, etc.), (b) a C 6-16 aryloxy-carbonyl group which may be substituted with a C 1-4 alkyl group, a hydroxyl group, a C 1-4 alkoxy group, a nitro group or a halogen atom (e.g. phenoxycarbonyl, 4-methylphenyloxycarbonyl, 4-methoxyphenyloxycarbonyl, 4-nitrophenyloxycarbonyl, 4-chlorophenyloxycarbonyl, naphtyloxycarbonyl, etc.), (c) a C 7-20 aralkyloxy-carbonyl group which may be substituted with a C 1-4 alkyl group, a C 6-12 aryl group such as phenyl group, a hydroxyl group, a C 1-4 alkoxy group, a nitro group or a halogen atom (for instance, benzyloxycarbonyl, m-chlorobenzyloxycarbonyl, p-methoxybenzyloxycarbonyl, and others), and (d) a carbamoyl group which may be substituted with a C 1-4 alkyl group, a C 7-20 aralkyl group, a C 1-6 acyl group, a C 7-16 acyl group having an aromatic group and others (e.g. carbamoyl, benzylaminocarbonyl, etc.). The carboxyl group may also form a salt. For such a salt, there is no restriction, and examples of the salt include a salt with an inorganic base including an alkali metal salt (e.g. a sodium salt, a potassium salt, etc.), an alkaline earth metal salt such as a magnesium salt, a calcium salt and a barium salt, the other metal salt such as a zinc salt and an aluminum salt, and an ammonium salt; a salt with an organic base including pyridine, a tri-C 1-4 alkylamine (e.g. trimethylamine, triethylamine, and so on). Examples of the lower alkoxycarbonyl group include a C 2-5 alkoxycarbonyl group such as methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, s-butoxycarbonyl, t-butoxycarbonyl, and so on. The substituent for the lower alkoxycarbonyl group include, for instance, those exemplified in the substituent for the alkoxy group as mentioned above. As the substituents for the optionally substituted amino group, there may be mentioned, for instance, an optionally substituted C 1-4 alkyl group, an optionally substituted C 7-20 aralkyl group, an optionally substituted C 1-6 acyl group, an optionally substituted C 7-16 acyl group having an aromatic ring, an optionally substituted acyl group having a heterocyclic group, as exemplified above and a substituted carbonyl group. As such substituted carbonyl group, there may be mentioned, for instance, an optionally substituted acyl group and a carboxyl group protected with a protective group as mentioned above. Typical examples of the optionally substituted amino group include (a) an amino group, (b) an amino group which is substituted with an optionally substituted C 1-4 alkyl group (for example, methylamino, ethylamino, propylamino, t-butylamino, dimethylamino, diethylthio, dipropylamino, dibutylamino, etc.), (c) an amino group substituted with an optionally substituted C 7-20 aralkyl group (for instance, benzylamino group and the like), (d) an amino group which is substituted with an optionally substituted C 1-6 acyl group (for instance, formylamino, acetylamino, valerylamino, isovalerylamino, pivaloylamino, etc.,), (e) an amino group which is substituted with an optionally substituted C 7-16 acyl group having an aromatic ring (e.g. benzoylamino group, etc.,), (f) an amino group substituted with an optionally substituted acyl group having a heterocyclic ring (for instance, nicotinoylamino group and the like), (g) an amino group which is substituted with a substituted carboxyl group (for instance, acetylaminomethylcarbonylamino, acetylaminoethylcarbonylamino, hydroxymethylcarbonylamino, hydroxyethylcarbonylamino, methoxycarbonylamino, ethoxycarbonylamino group and the like). Preferred examples of R 1 and R 5 include a hydrogen atom, a C 1-4 alkyl group, and others, especially a hydrogen atom. As the typical examples of R 2 , R 3 , R 4 , there may be mentioned a hydrogen atom, a halogen atom, a C 1-4 alkyl group which may be substituted with a halogen atom or a hydroxyl group including, for example, a C 1-4 alkyl group, a C 1-4 haloalkyl group, a hydroxy-C 1-4 alkoxy group etc., a hydroxy group, a C 1-4 alkoxy group, a C 7-20 aralkyloxy group, a C 7-20 acyl group having an aromatic ring, an optionally substituted amino group (specifically an amino group which is substituted with a C 1-6 acyl group) and a nitro group. Specifically preferred of R 2 , R 3 and R 4 include, for example, a halogen atom. Examples of the protective group for hydroxyl group in Z include protective groups for hydroxyl group generally used in the field of organic synthesis, such as the protective groups for hydroxyl group (A) to (D) as mentioned above in the explanation of R 1 to R 5 . Practically, a hydrogen atom, a silyl group which may be substituted with for example a C 1-4 alkyl group, a C 1-6 acyl group, especially a hydrogen atom is frequently used as Z. Typical examples of the compound shown by the general formula (II) include, other than (a) (R)-2-amino-1-phenylethanol, (b) (R)-2-amino-1-phenylethanol derivatives which are protected on the hydroxyl group, (c) (R)-2-amino-1-phenylethanol derivatives which are substituted with a hydroxyl group on the phenyl group, (d) (R)-2-amino-1-phenylethanol derivatives substituted with two hydroxyl groups on the phenyl group, (e) (R)-2-amino-1-phenylethanol derivatives substituted with a halogen atom on the phenyl group, (f) (R)-2-amino-1-phenylethanol derivatives substituted with two halogen atoms on the phenyl group, (g) (R)-2-amino-1-phenylethanol derivatives substituted with three halogen atoms on the phenyl group, (h) (R)-2-amino-1-phenylethanol derivatives substituted with four halogen atoms on the phenyl group, (i) (R)-2-amino-1-phenylethanol derivatives substituted with five halogen atoms on the phenyl group, (j) (R)-2-amino-1-phenylethanol derivatives substituted with an optionally substituted lower alkyl group on the phenyl group, (k) (R)-2-amino-1-phenylethanol derivatives substituted with an optionally substituted lower alkoxy group on the phenyl group, (l) (R)-2-amino-1-phenylethanol derivative substituted with a nitro group on the phenyl group, (m) (R)-2-amino-1-phenylethanol derivatives substituted with an optionally substituted amino group on the phenyl group, (n) (R)-2-amino-1-phenylethanol derivatives substituted with a hydroxyl group which may be protected with a protective group, an optionally substituted cycloalkyloxy group, an optionally substituted aralkyloxy group, an optionally substituted aryloxy group, an optionally substituted amino group, a carboxyl group which may be protected with a protective group, and the like. Examples of the (R) 2-amino-1-phenylethanol derivatives which are protected on the hydroxyl group (b) include (R)-2-amino-1-phenyl-O-trimethylsilylethanol, (R)-2-amino-1-phenyl-O-t-butyldimethylsilylethanol, (R)-2-amino-1-phenyl-O-tetrahydropyranylethanol, (R)-2-amino-1-phenyl-O-acetylethanol and others. As the derivatives (c) substituted with a hydroxyl group on the phenyl group, there may be mentioned, for instance, (R)-2-amino-1-(2-hydroxyphenyl)ethanol, (R)-2-amino-1-(3-hydroxyphenyl) ethanol, (R)-2-amino-1-(4-hydroxyphenyl)ethanol, (R)-2-amino-1-(3-methylthio-4-hydroxyphenyl)ethanol, (R)-2-amino-1-(3-hydroxymethyl-4-hydroxyphenyl)ethanol, (R)-2-amino-1-(3-methoxycarbonyl-4-hydroxyphenyl)ethanol, (R)-2-amino-1-(3-hydroxyethoxy-4-hydroxyphenyl) ethanol, (R)-2-amino-1-(3-ethoxymethyl-4-hydroxyphenyl)ethanol, (R)-2-amino-1-[3-hydroxy-5-(1,2-dihydroxypropyl)phenyl]ethanol and so on. The derivatives (d) substituted with two hydroxyl groups on the phenyl group include, for example, (R)-2-amino-1-(2,3-dihydroxyphenyl)ethanol, (R)-2-amino-1-(2,4-dihydroxyphenyl)ethanol, (R)-2-amino-1-(2,5-dihydroxyphenyl)ethanol, (R)-2-amino-1-(2,6-dihydroxyphenyl)ethanol, (R)-2-amino-1-(3,4-dihydroxyphenyl)ethanol, (R)-2-amino-1-(3,5-dihydroxyphenyl)ethanol, (R)-2-amino-1-(4,5-dihydroxy-3-methylphenyl)ethanol, (R)-2-amino-1-(3,4-dihydroxy-2-methylphenyl)ethanol and others. Examples of the derivatives (e) substituted with a halogen atom on the phenyl group include an (R)-2-amino-1-(2-halophenyl)ethanol derivative such as (R)-2-amino-1-(2-fluorophenyl)ethanol, (R)-2-amino-1-(2-chlorophenyl) ethanol, (R)-2- amino-1-(2-bromophenyl)ethanol, (R)-2-amino-1-(2-iodophenyl)ethanol, (R)-2-amino-1-(2-chloro-3-hydroxyphenyl)ethanol, (R)-2-amino-1-(2-chloro-4-hydroxyphenyl)ethanol, (R)-2-amino-1-(2-chloro-4-benzyloxyphenyl)ethanol, etc.; an (R)-2-amino-1-(3-halophenyl)ethanol derivative such as (R)-2-amino-1-(3-chlorophenyl)-O-trimethylsilylethanol, (R)-2-amino-1-(3-chlorophenyl)-O-t-butyldimethylsilylethanol, (R)-2-amino-1-(3-chlorophenyl)-O-acetylethanol, (R)-2-amino-1-(2-chlorophenyl)ethanol, (R)-2-amino-1-(3-chlorophenyl)ethanol, (R)-2-amino-1-(3-bromophenyl)ethanol, (R)-2-amino-1-(3-iodophenyl)ethanol, (R)-2-amino-1-(3-fluoro-4-methoxyphenyl)ethanol, (R)-2-amino-1-(3-chloro-4-methoxyphenyl)ethanol, (R)-2-amino-1-(4-benzyloxy-3-chloro-5-methoxyphenyl)ethanol, (R)-2-amino-1-(5-ethoxy-4-benzyloxy-3-chlorophenyl)ethanol, and (R)-2-amino-1-(3-chloro-4-methylthiophenyl) ethanol; an (R)-2-amino-1-(4-halophenyl)ethanol derivative such as (R)-2-amino-1-(4-fluorophenyl)ethanol, (R)-2-amino-1-(4-chlorophenyl)ethanol, (R)-2-amino-1-(4-bromophenyl) ethanol, (R)-2-amino-1-(4-iodophenyl)ethanol, and the like. As the derivatives (f) substituted with two halogen atoms on the phenyl group, there may be mentioned, for example, (R)-2-amino-1-(2,3-dihalophenyl) ethanol derivatives such as (R)-2-amino-1-(2,3-difluorophenyl)ethanol, (R)-2-amino-1-(2,3-dichloro phenyl) ethanol, (R)-2-amino-1-(2, 3-dibromophenyl) ethanol, (R)-2-amino-1-(2,3-diiodophenyl)ethanol, (R)-2-amino-1-(2-fluoro-3-chlorophenyl)ethanol and so on; (R)-2-amino-1-(2,4-dihalophenyl)ethanol derivatives such as (R)-2-amino-1-(2,4-difluorophenyl)ethanol, (R)-2-amino-1-(2,4-dichlorophenyl)ethanol, (R)-2-amino-1-(2,4-dibromophenyl)ethanol, (R)-2-amino-1-(2,4-diiodophenyl)ethanol and the like; (R)-2-amino-1-(2,5-dihalophenyl)ethanol derivatives such as (R)-2-amino-1-(2,5-difluorophenyl) ethanol, (R)-2-amino-1-(2,5-dichloro phenyl)ethanol, (R)-2-amino-1-(2,5-dibromophenyl) ethanol and (R)-2-amino-1-(2,5-diiodophenyl)ethanol; an (R)-2-amino-1-(2,6-dihalophenyl)ethanol derivative such as (R)-2-amino-1-(2,6-difluorophenyl)ethanol, (R)-2-amino-1-(2,6-dichlorophenyl)ethanol, (R)-2-amino-1-(2,6-dibromophenyl)ethanol, (R)-2-amino-1-(2,6-diiodophenyl)ethanol and the like; (R)-2-amino-1-(3,4-dihalophenyl)ethanol derivatives such as (R)-2-amino-1-(3,4-difluorophenyl)ethanol, (R)-2-amino-1-(3,4-dichlorophenyl)ethanol, (R)-2-amino-1-(3,4-dibromophenyl)ethanol, (R)-2-amino-1-(3,4-diiodophenyl)ethanol, (R)-2-amino-1-(3-chloro-4-bromophenyl) ethanol, (R)-2-amino-1-(3,4-dichlorophenyl)-O-trimethylsilylethanol, (R)-2-amino-1-(3,4-dichlorophenyl)-O-acetylethanol and so on; (R)-2-amino-1-(3,5-dihalophenyl)ethanol derivatives such as (R)-2-amino-1-(3,5-difluorophenyl)ethanol, (R)-2-amino-1-(3,5-dichlorophenyl)ethanol, (R)-2-amino-1- (3,5-dibromophenyl)ethanol, (R) -2-amino-1-(3,5-diiodophenyl)ethanol, (R)-2-amino-1-(3,5-difluoro-4-methylaminophenyl)ethanol, (R)-2-amino-1-(3,5-dichloro-4-methylaminophenyl)ethanol, (R)-2-amino-1-(3,5-dibromo- 4-methylaminophenyl) ethanol, (R)-2-amino-1-(3,5-dichloro-4-aminophenyl)ethanol, (R)-2-amino-1-(3,5-dichloro-4-methylphenyl)ethanol, (R)-2-amino-1-(3,5-dichloro-4-ethoxycarbonylaminophenyl) ethanol, (R)-2-amino-1-(4-amino-3-bromo-5-fluorophenyl)ethanol and (R)-2-amino-1-(4-amino-3-bromo-5-chlorophenyl)ethanol; and the like. The derivatives (g) substituted with three halogen atoms on the phenyl group include, for instance, (R)-2-amino-1-(2,3,4-trihalophenyl)ethanol derivatives such as (R)-2-amino-1-(2,3,4-trifluolophenyl)ethanol, (R)-2-amino-1-(2,3,4-trichlorophenyl)ethanol, (R)-2-amino-1-(2,3,4-tribromophenyl)ethanol, (R)-2-amino-1-(2,3,4-triiodophenyl)ethanol and so on; (R)-2-amino-1-(2,3,5-trihalophenyl) ethanol derivatives such as (R)-2-amino-1-(2,3,5-trifluorophenyl)ethanol, (R)-2-amino-1-(2,3,5-trichlorophenyl)ethanol, (R)-2-amino-1-(2,3,5-tribromophenyl)ethanol and (R)-2-amino-1-(2,3,5-triiodophenyl) ethanol; (R)-2-amino-1-(2,3,6-trihalophenyl)ethanol derivatives such as (R)-2-amino-1-(2,3,6-trifluolophenyl)ethanol, (R)-2-amino-1-(2,3,6-trichlorophenyl)ethanol, (R)-2-amino-1-(2,3,6-tribromophenyl)ethanol, (R)-2-amino-1-(2,3,6-triiodophenyl) ethanol and the like; (R)-2-amino-1-(2,4,5-trihalophenyl)ethanol derivatives such as (R)-2-amino-1-(2,4,5-trifluolophenyl)ethanol, (R)-2-amino-1-(2,4,5-trichlorophenyl) ethanol, (R)-2-amino-1-(2,4,5-tribromophenyl) ethanol and (R)-2-amino-1-(2,4,5-triiodophenyl)ethanol; (R)-2-amino-1-(2,4,6-trihalophenyl)ethanol derivatives such as (R)-2-amino-1-(2,4,6-trifluolophenyl) ethanol, (R)-2-amino-1-(2,4,6-trichlorophenyl)ethanol, (R)-2-amino-1-(2,4,6-tribromophenyl) ethanol, (R)-2-amino-1-(2,4,6-triiodophenyl)ethanol and so on; an (R)-2-amino-1-(3,4,5-trihalophenyl)ethanol derivative such as (R)-2-amino-1-(3,4,5-trifluorophenyl)ethanol, (R)-2-amino-1-(3,4,5-trichlorophenyl)ethanol, (R)-2-amino-1-(3,4,5-tribromophenyl) ethanol, (R)-2-amino-1-(3,4,5-triiodophenyl)ethanol, (R)-2-amino-1-(3-chloro-4,5-difluorophenyl)ethanol, (R)-2-amino-1-(3-fluoro-4,5-dichlorophenyl)ethanol and the like. Examples of the derivatives (h) substituted with four halogen atoms on the phenyl group include an (R)-2-amino-1-(2,3,4,5-tetrahalophenyl)ethanol derivative such as (R)-2-amino-1-(2,3,4,5-tetrafluorophenyl)ethanol, (R)-2-amino-1-(2,3,4,5-tetrachlorophenyl)ethanol, (R)-2-amino-1-(2,3,4,5-tetrabromophenyl)ethanol, (R)-2-amino-1-(2,3,4,5-tetraiodophenyl)ethanol and others; an (R)-2-amino-1-(2,3,4,6-tetrahalophenyl)ethanol derivative such as (R)-2-amino-1-(2,3,4,6-tetrafluorophenyl) ethanol, (R)-2-amino-1-(2,3,4,6-tetrachlorophenyl) ethanol, (R)-2-amino-1-(2,3,4,6-tetrabromophenyl) ethanol, (R)-2-amino-1-(2,3,4,6-tetraiodophenyl)ethanol, etc.; an (R)-2-amino-1-(2,3,5,6-tetrahalophenyl)ethanol derivative such as (R)-2-amino-1-(2,3,5,6-tetrafluorophenyl) ethanol, (R)-2-amino-1-(2,3,5,6-tetrachlorophenyl)ethanol, (R)-2-amino-1-(2,3,5,6-tetrabromophenyl) ethanol, (R)-2-amino-1-(2, 3, 5, 6-tetraiodophenyl)ethanol and the like. The derivatives (i) substituted with five halogen atoms on the phenyl group include, for instance, (R)-2-amino-1-(2,3,4,5,6-pentafluorophenyl)ethanol, (R)-2-amino-1-(2,3,4,5,6-pentachlorophenyl)ethanol, (R)-2-amino-1-(2,3,4,5,6-pentabromophenyl)ethanol, (R)-2-amino-1-(2,3,4,5,6-pentaiodophenyl)ethanol and so on. Examples of the derivatives (j) substituted with an optionally substituted lower alkyl group on the phenyl group include an (R)-2-amino-1-(2-C 1-4 alkylphenyl)ethanol derivative such as (R)-2-amino-1-(2-methylphenyl)ethanol, (R)-2-amino-1-(2-ethylphenyl) ethanol, (R)-2-amino-1-(2-propylphenyl)ethanol, (R)-2-amino-1-(2-t-butylphenyl)ethanol and (R)-2-amino-1-(2-methylphenyl)-O-trimethylsilylethanol; an (R)-2-amino-1-(3-C 1-4 alkyl-phenyl)ethanol derivative such as (R)-2-amino-1-(3-methylphenyl)ethanol, (R)-2-amino-1-(3-ethylphenyl)ethanol, (R)-2-amino-1-(3-propylphenyl)ethanol, (R)-2-amino-1-(3-t-butylphenyl)ethanol and (R)-2-amino-1-(3-methylphenyl)-O-trimethylsilylethanol; an (R)-2-amino-1-(4-C 1-4 alkyl-phenyl)ethanol derivative such as (R)-2-amino-1-(4-methylphenyl)ethanol, (R)-2-amino-1-(4-ethylphenyl)ethanol, (R)-2-amino-1-(4-propylphenyl) ethanol, (R)-2-amino-1-(4-t-butylphenyl)ethanol and (R)-2-amino-1-(4-methylphenyl)-O-trimethylsilylethanol; an (R)-2-amino-1-(2-C 1-4 haloalkyl-phenyl)ethanol derivative such as (R)-2-amino-1-(2-chloromethylphenyl)ethanol, (R)-2-amino-1-[2-(2-chloroethyl)phenyl]ethanol, (R)-2-amino-1-[2-(3-chloropropyl)phenyl]ethanol, (R)-2-amino-1-[2-(4-chlorobutyl)phenyl]ethanol, (R)-2-amino-1-(2-trichloromethylphenyl)ethanol, (R)-2-amino-1-(2-trifluoromethylphenyl)ethanol and (R)-2-amino-1-(2-chloromethylphenyl)-O-trimethylsilylethanol; an (R)-2-amino-1-(3-C 1-4 haloalkyl-phenyl)ethanol derivative such as (R)-2-amino-1-(3-chloromethylphenyl)ethanol, (R)-2-amino-1-[3-(2-chloroethyl)phenyl]ethanol, (R)-2-amino-1-[3-(3-chloropropyl]phenyl]ethanol, (R)-2-amino-1-[3-(4-chlorobutyl)phenyl]ethanol, (R)-2-amino-1-(3-trichloromethylphenyl)ethanol, (R)-2-amino-1-(3-trifluoromethylphenyl)ethanol, (R)-2-amino-1-(3-trifluoromethylphenyl)-O-trimethylsilylethanol, (R)-2-amino-1-(3-trifluoromethylphenyl)-O-acetylethanol, (R)-2-amino-1-[3-(1,1,2,2,2-pentafluoroethyl) phenyl]-O-acetylethanol and (R)-2-amino-1-(3-chloromethylphenyl)-O-trimethylsilylethanol; an (R)-2-amino-1-(4-C 1-4 haloalkyl-phenyl)ethanol derivative such as (R)-2-amino-1-(4-chloromethylphenyl)ethanol, (R)-2-amino-1-[4-(2-chloroethyl)phenyl]ethanol, (R)-2-amino-1-[4-(3-chloropropyl)phenyl]ethanol, (R)-2-amino-1-[4-(4-chlorobutyl)phenyl]ethanol, (R)-2-amino-1-(4-trichloromethylphenyl)ethanol, (R)-2-amino-1-(4-trifluoromethylphenyl)ethanol and (R)-2-amino-1-(4-chloromethylphenyl)-O-trimethylsilylethanol; an (R)-2-amino-1-[3-(hydroxy-C 1-4 alkyl)phenyl]ethanol derivative such as (R)-2-amino-1-[3-(hydroxymethyl)phenyl]ethanol and so on. As the derivatives (k) substituted with a lower alkoxy group on the phenyl group, there may be mentioned, for example, a derivative substituted with one lower alkoxy group on the phenyl group such as (R)-2-amino-1-(2-methoxyphenyl) ethanol, (R)-2-amino-1-(3-methoxyphenyl)ethanol, (R)-2-amino-1-(4-methoxyphenyl)ethanol, (R)-2-amino-1-(2-ethoxyphenyl)ethanol, (R) -2-amino-1-(3-ethoxyphenyl) ethanol, (R)-2-amino-1-(4-ethoxyphenyl)ethanol and so on; a derivative substituted with two lower alkoxy groups on the phenyl group such as (R)-2-amino-1-(2,3-dimethoxyphenyl)ethanol, (R)-2-amino-1-(2,3-diethoxyphenyl)ethanol, (R)-2-amino-1-(2,4-dimethoxyphenyl) ethanol, (R)-2-amino-1-(2, 4-diethoxyphenyl)ethanol, (R)-2-amino-1-(2,5-dimethoxyphenyl)ethanol, (R)-2-amino-1-(2,5-diethoxyphenyl)ethanol, (R)-2-amino-1-(2,6-dimethoxyphenyl)ethanol, (R)-2-amino-1-(2,6-diethoxyphenyl) ethanol, (R)-2-amino-1-(3,4-dimethoxyphenyl)ethanol, (R)-2-amino-1-(3,4-diethoxyphenyl)ethanol, (R)-2-amino-1-(3,5-dimethoxyphenyl)ethanol, (R)-2-amino-1-(3,5-diethoxyphenyl)ethanol and (R)-2-amino-1-(3-hydroxyethoxy-4-t-butoxyphenyl)ethanol; a derivative which is substituted with an alkoxy group and a hydroxyl group on the phenyl group such as (R)-2-amino-1-(2-hydroxy-3-methoxyphenyl)ethanol, (R)-2-amino-1-(2-hydroxy-4-methoxyphenyl)ethanol, (R)-2-amino-1-(2-hydroxy-5-methoxyphenyl) ethanol, (R)-2-amino-1-(2-hydroxy-6-methoxyphenyl)ethanol, (R)-2-amino-1-(3-hydroxy-2-methoxyphenyl)ethanol, (R)-2-amino-1-(3-hydroxy-4-methoxyphenyl)ethanol, (R)-2-amino-1-(3-hydroxy-5-methoxyphenyl)ethanol, (R)-2-amino-1-(3-hydroxy-6-methoxyphenyl)ethanol, (R)-2-amino-1-(4-hydroxy-2-methoxyphenyl)ethanol, (R)-2-amino-1-(4-hydroxy-3-methoxyphenyl)ethanol, (R)-2-amino-1-(5-hydroxy-2-methoxyphenyl)ethanol, (R)-2-amino-1-(5-hydroxy-3-methoxyphenyl)ethanol, (R)-2-amino-1-(6-hydroxy-2-methoxyphenyl)ethanol, (R)-2-amino-1-(6-hydroxy-3-methoxyphenyl)ethanol, (R)-2-amino-1-(2-hydroxy-3-ethoxyphenyl) ethanol, (R)-2-amino-1-(2-hydroxy-4-ethoxyphenyl)ethanol, (R)-2-amino-1-(2-hydroxy-5-ethoxyphenyl)ethanol, (R)-2-amino-1-(2-hydroxy-6-ethoxyphenyl)ethanol, (R)-2-amino-1-(3-hydroxy-2- ethoxyphenyl)ethanol, (R)-2-amino-1-(3-hydroxy-4-ethoxyphenyl)ethanol, (R)-2-amino-1-(3-hydroxy-5-ethoxyphenyl)ethanol, (R)-2-amino-1-(3-hydroxy-6-ethoxyphenyl)ethanol, (R)-2-amino-1-C4-hydroxy-2-ethoxyphenyl)ethanol, (R)-2-amino-1-(4-hydroxy-3-ethoxyphenyl)ethanol, (R)-2-amino-1-(5-hydroxy-2-ethoxyphenyl)ethanol, (R)-2-amino-1-(5-hydroxy-3-ethoxyphenyl)ethanol, (R)-2-amino-1-(6-hydroxy-2-ethoxyphenyl)ethanol, (R)-2-amino-1-(6-hydroxy-3-ethoxyphenyl)ethanol and others. The derivatives (1) substituted with a nitro group on the phenyl group include, for example, (R)-2-amino-1-(2-nitrophenyl)ethanol, (R)-2-amino-1-(3-nitrophenyl)ethanol, (R)-2-amino-1-(2-methyl-3-nitrophenyl)ethanol, (R)-2-amino-1-(4-nitrophenyl)ethanol and the like. Examples of the derivative (m) substituted with an optionally substituted amino group on the phenyl group include (R)-2-amino-1-(3-aminophenyl)ethanol, (R)-2-amino-1- (3-amino-4-methoxyphenyl)ethanol, (R)-2-amino-1-1-(3-acetylaminophenyl)ethanol, (R)-2-amino-1-(4-acetylaminophenyl)ethanol, (R)-2-amino-1-(3-acetylamino-4-hydroxyphenyl)ethanol, (R)-2-amino-1-(3-acetylamino-4-methoxyphenyl) ethanol, (R)-2-amino-1-(3-acetylamino-4-benzyloxyphenyl)ethanol, (R)-2-amino-1-(3-acetylaminomethylcarbonylamino-4-hydroxyphenyl) ethanol, (R)-2-amino-1-(3-formylamino-4-hydroxyphenyl)ethanol, (R)-2-amino-1-(3-hydroxymethylcarbonylamino-4-hydroxyphenyl)ethanol, (R)-2-amino-1-[3-hydroxymethylcarbonylamino-4-(p-methoxyphenyl)methylphenyl]ethanol, (R)-2-amino-1-(5-formylamino-3-hydroxyphenyl)ethanol, (R)-2-amino-1-(3-carbamoyl-4-hydroxyphenyl)ethanol, and so on. As the derivatives (n) substituted with a hydroxyl group which may be protected with a protective group, an optionally substituted cycloalkyloxy group, an optionally substituted aralkyloxy group, an optionally substituted aryloxy group, an optionally substituted acyl group, or a carboxyl group which may be protected with a protective group, there may be mentioned, for example, (R)-2-amino-1-(2-benzyloxyphenyl)ethanol, (R)-2-amino-1-(2-benzylcarbonylphenyl)ethanol, (R)-2-amino-1-(2-benzylcarbonyloxyphenyl)ethanol, (R)-2-amino-1-(3-methoxycarbonyl-4-cyclohexyloxyphenyl)ethanol, (R)-2-amino-1-(3,4-dibenzyloxyphenyl)ethanol, (R)-2-amino-1-(3-hydroxymethyl-4-benzyloxyphenyl)ethanol, (R)-2-amino-1-(3,5-dibenzyloxyphenyl)ethanol, (R)-2-amino-1-(3,5-di-t-butoxycarbonylphenyl)ethanol and the like. Preferred examples of the compound shown by the general formula (II) as exemplified above include (R)-2-amino-1-phenylethanol; an (R)-2-amino-1-phenylethanol derivative substituted with a halogen atom(s) on the phenyl group [for example, a derivative substituted with one or two of halogen atoms, specifically a derivative substituted with one or two of halogen atoms on the 2-, 3- or 4-position of the phenyl group such as an (R)-2-amino-1-(3-halophenyl)ethanol derivative, (R)-2-amino-1-(4-halophenyl)ethanol derivative, an (R)-2-amino-1-(3,4-dihalophenyl)ethanol derivative and the like]; an (R)-2-amino-1-phenylethanol derivative substituted, on the phenyl group, with an optionally substituted C 1-4 alkyl group, an optionally substituted C 1-4 alkoxy group or an optionally substituted amino group such as an (R)-2-amino-1-(3-C 1-4 alkyl-phenyl)ethanol derivative, an (R)-2-amino-1-(3-C 1-4 haloalkyl-phenyl)ethanol derivative, an (R)-2-amino-1-(3-C 1-4 alkoxy-phenyl)ethanol derivative, an (R)-2-amino-1-(3-C 1-6 acylaminophenyl)ethanol derivative, an (R)-2-amino-1-(4-C 1-4 alkyl-phenyl)ethanol derivative, an (R)-2-amino-1-(4-C 1-4 haloalkyl-phenyl)ethanol derivative, an (R)-2-amino-1-(4-C 1-4 alkoxy-phenyl)ethanol derivative, an (R)-2-amino-1-(4-C 1-6 acylaminophenyl)ethanol derivative and others. The (R)-2-amino-1-phenylethanol derivative shown by the general formula (II) wherein Z is a hydrogen atom, namely, the compound shown by the general formula (IIa) can be prepared by various methods, for example, a chemical synthetic method, and the compound of the general formula (IIa) can advantageously be produced by a method utilizing a microorganism or a preparation thereof. The optically active (R)-form shown by the general formula (IIa) can be readily or easily prepared, for example, by (A) permitting a specific microorganism or a preparation thereof to act on the compound of the general formula (VII) or a salt thereof, and harvesting or recovering the product (R)-2-amino-1-phenylethanol derivative. The method (A) just mentioned above is explained hereinbelow. In the method (A), the compound of the general formula (IIa) or a salt thereof can easily or readily be obtained by permitting a microorganism or a preparation thereof to act on the compound of the general formula (VII) or a salt thereof (aminoketone derivative) to asymmetrically reduce and harvesting or recovering the produced (R)-2-amino-1-phenylethanol derivative. As examples of the aminoketone derivative of the general formula (VII) used as a raw material, there may be mentioned aminoketone derivatives corresponding to the compounds as mentioned as practical examples of the (R)-2-amino-1-phenylethanol derivative of the general formula (II). The aminoketone derivative can be used as a free amine-form but a salt with an inorganic acid or an organic acid may also be employed. The inorganic acid include, for example, hydrochloric acid, sulfuric acid, phosphoric acid and so on. As the organic acid, for instance, the aliphatic monocarboxylic acids and aliphatic polycarboxylic acids and the like exemplified in the explanation of the isolation and purification of the 2-amino-1-phenylethanol derivative may be employed. The compound of the general formula (VII) can be prepared by a known method, for example, by allowing the compound shown by the general formula (XVIII) wherein R 1 , R 2 , R 3 , R 4 , R 5 have the same meanings as defined above, and X represents a halogen atom to react with an aminating agent. As the aminating agent, there may be employed hexamethylenetetramine and others, as well as the following aminating agents: As the aminating agent, for example, a compound shown by the general formula (V) Y-NH 2 wherein Y represents a hydrogen atom or a group which can be left in the reaction, can be employed. Examples of the group represented by Y which can be left in the reaction include an optionally substituted C 1-4 alkyl group (for example, allyl group; phenacyl group; a C 1-6 acyloxy-C 1-4 alkyl group such as 3-acetoxypropyl group; an optionally substituted C 1-4 alkoxy-C 1-4 alkyl group such as methoxymethyl, 2-chloroethoxymethyl group and so on; a C 7-16 aralkyloxy-C 1-4 alkyl group such as benzyloxymethyl group; an optionally substituted a C 7-16 aralkyl group (for instance, benzyl, triphenylmethyl, a C 1-4 alkoxy-C 7-16 aralkyl group such as 3,4-dimethoxybenzyl, di(p-methoxyphenyl)methyl and (p-methoxyphenyl)diphenylmethyl group) and others. As the C 1-4 alkyl group and the like, there may be employed the C 1-4 alkyl group and the like as mentioned in the explanation of R 1 to R 5 . Practical examples of Y include a hydrogen atom. Examples of the halogen atom shown by X include fluorine atom, chorine atom, bromine atom and iodine atom. Any strain of microorganism can be used for the process, as far as being capable of acting on the aminoketone derivative of the general formula (VII) to produce the corresponding (R)-2-amino-1-phenylethanol derivative of the general formula (IIa). Such microorganisms having the capability include, for instance, a strain of microorganism belonging to the genus Candida, the genus Lodderomyces, the genus Catenuloplanes , the genus Pilimelia , the genus Saccharothrix, the genus Seratia, the genus Enterococcus, the genus Lactobacillus , the genus Pediococcus and the genus Lactococcus. Typical examples of the microorganism that is capable of acting on the aminoketone compound to produce the corresponding (R)-2-amino-1-phenylethanol derivative include following strains of microorganisms: (56) the genus Candida : Candida maltosa IFO 1977, Candida maltosa IFO 1978, etc., (57) the genus Lodderomyces : Lodderomyces elongisporus IFO 1676, etc., (58) the genus Catenuloplanes : Catenuloplanes japonicus IFO 14176, etc., (59) the genus Pilimelia : Pilimelia terevasa IFO 14556, etc., (60) the genus Saccharothrix : Saccharothrix australiensis IFO 14444, etc., (61) the genus Seratia : Seratia marcescens IFO 3735, etc., (62) the genus Enterococcus : Enterococcus faecalis IFO 12964, etc., (63) the genus Lactobacillus : Lactobacillus casei subsp. casei NRIC 1042, etc., (64) the genus Pediococcus : Pediococcus acidilactici NRIC 1089, etc., (65) the genus Lactococcus : Lactococcus lactis subsp. lactis AHU 1089, etc. At least one of these microorganisms can be employed. For the purposes of the invention, any of wild strains, mutants and recombinant strains which can be obtained by a genetic engineering technique such as cell fusion or gene manipulation can suitably be used, as far as having the above mentioned ability or capability. The microorganisms identified hereinabove by IFO numbers and AHU number can be available from the organizations. The strain of microorganism designated by NRIC number is listed in "Catalogue of Microbial Strains 2nd Ed. (1992)" published by the Laboratory of Microbial Strain Collection, Tokyo Agriculture University, Japan and is available from the institution. The cultivation, reaction, and recovery of the product can be carried out as follows: A microorganism such as above is, usually, grown in a culture medium and submitted to the reaction with the appropriate starting materials. The medium used for growing the strain for use in the invention is not critical in composition only if the selected strain may grow and multiply therein. The medium may frequently be a fluid medium containing sources of carbon and nitrogen and other nutrients. Any carbon source which the strain can utilize may be employed. As the sources of carbon, there may be employed, for example, various carbohydrates or saccharides such as glucose, fructose, sucrose, dextrin, starch, etc.; alcohols such as sorbitol, methanol, ethanol, glycerol, etc.; organic acids such as fumaric acid, citric acid, acetic acid, propionic acid, etc. and the corresponding salts; hydrocarbons such as paraffin; and various mixtures thereof. The sources of nitrogen include, for instance, inorganic acid ammonium salts such as ammonium chloride, ammonium sulfate, ammonium phosphate, etc.; organic acid ammonium salts such as ammonium fumarate, ammonium citrate, etc.; inorganic or organic nitrogen-containing materials such as meat extract, yeast extract, malt extract, peptone (polypeptone), corn steep liquor, casein hydrolysate, urea, etc.; and various mixtures thereof. In the medium, there may be incorporated appropriate amounts of those nutrients which are commonly employed in the cultivation of microorganisms, such as inorganic salts, trace metal salts and vitamins. Where necessary, there may also be incorporated factors which may promote growth of the strain used and/or factors which may augment its ability to produce the object compound of the invention, for example, the 2-amino-1-phenylethanol derivative of the general formula (I), as well as a buffer substance which may assist in the maintenance of the medium at a given pH. The cultivation of the microorganism is carried out under conditions optimal for the growth of the particular strain, for example at a medium pH in the range of about 2.0 to 9.5, preferably about 3 to 8, and an incubation temperature in the range of about 20 to 45°C, preferably about 25 to 37°C. The cultivation may be aerobic or anaerobic. The cultivation time is, for example, about 5 to 120 hours, preferably about 12 to 72 hours. The compound of the general formula (IIa) can readily or easily be converted to the compound of the general formula (II) by, if necessary, introducing a suitable protective group to the hydroxyl group. Such compound of the general formula (II) is useful for the production of the (R, R) -1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative. The process of producing the (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative of the general formula (XI) is illustrated hereinbelow. In R 7 and R 8 of the general formula (XI), as the optionally substituted C 1 -C 4 alkyl group, the carboxyl group which may be protected with a protective group, the optionally substituted C 2 -C 5 alkoxycarbonyl group, the optionally substituted amino group, the optionally substituted alkylsulfonyl group and the optionally substituted arylsulfonyl group, there may be employed the optionally substituted C1-C4 alkyl group and the like as mentioned in the explanation of R 1 to R 5 . The optionally substituted aryl group, the optionally substituted aralkyl group and the optionally substituted acyl group in R 7 and R 8 include, for instance, an optionally substituted C 6-16 aryl group and an optionally substituted C 7-20 aralkyl group and an optionally substituted acyl group as exemplified in the explanation of the protective group for hydroxyl group. As examples of the optionally substituted cycloalkyl group, there may be mentioned a C 3-10 cycloalkyl group (e.g. cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl or cyclodecyl group) which may be substituted with a substituents such as a C 1-4 alkyl group, a hydroxyl group, a halogen atom and so on. The protective group for hydroxyl group in R 7 and R 8 include, for example, protective groups for hydroxyl group generally used in the field of organic synthesis such as the protective groups for hydroxyl group (A) to (D) exemplified in R 1 to R 5 . When R 7 and R 8 are respectively the group (IX) : -O-R 7a and the group (X): -O-R 8a , and R 7a and R 8a form a ring together with the adjacent oxygen atoms, the ring may for example be a 5- to 10-membered ring, preferably a 5- to 8-membered ring and more preferably a 5- or 6-membered ring. Such R 7a and R 8a includes, for instance, an optionally substituted alkylene group, a carbonyl group, a thiocarbonyl group and others. As the alkylene group, there may be mentioned, for instance, an alkylene group having 1 to 4 carbon atoms such as methylene, ethylene, trimethylene and the like. Preferred alkylene group includes a methylene group. The optionally substituted methylene group includes, for example, a group shown by the following formula (XII) wherein R a and R b represent, (i) the same or different, a hydrogen atom, a C 1-4 alkyl group, a C 1-4 haloalkyl group, an optionally substituted C 6-20 aryl group, a C 1-4 alkoxy group, an optionally substituted amino group, a carboxyl group or a salt thereof, an optionally substituted alkoxycarbonyl group, a hydroxymethyl group or an optionally substituted alkoxymethyl group, or (ii) R a and R b may form a C 5-7 cycloalkyl group together with the adjacent carbon atom. The C 1-4 alkyl group, the C 1-4 haloalkyl group and the C 1-4 alkoxy group in R a and R b include those exemplified in R 1 to R 5 . The optionally substituted C 6-20 aryl group in R a and R b includes, for instance, phenyl, 4-methoxyphenyl, 2-nitrophenyl and others. As the substituted amino group, there may be mentioned, for example, a mono- or di-C 1-4 alkylamino group such as methylamino, dimethylamino, ethylamino, diethylamino and others. As the substituents for the C 6-20 aryl group, amino group and the like, there may be referred to those mentioned in the explanation of R 1 to R 5 . As the salt of the carboxyl group represented by R a and R b , any salt can be employed. A salt which is pharmacologically acceptable may frequently be used. Examples of such salt include a salt with an inorganic base such as an alkali metal salt (e.g. a sodium salt or a potassium salt), an alkaline earth metal salt (for instance, a magnesium salt, a calcium salt or a barium salt), a metal salt (e.g. a zinc salt or an aluminum salt) and an ammonium salt; a salt with an organic base such as a salt with pyridine, a tri-C 1-3 alkylamine (e.g. trimethylamine, triethylamine, etc.) and so on. The optionally substituted alkoxycarbonyl group in R a and R b includes, for instance, an optionally substituted C 2-5 alkoxycarbonyl group as mentioned in R 1 to R 5 . As examples of the optionally substituted alkoxymethyl group in R a and R b , there may be mentioned an optionally substituted a C 1-4 alkoxy-methyl group which may be substituted on the alkyl with a substituent. Such substituent for the alkoxymethyl group include, for example, a carboxyl group, a C 2-5 alkoxycarbonyl group, a hydroxyl group and a C 1-4 alkoxy group. The C 2-5 alkoxycarbonyl group and the C 1-4 alkoxy group in the C 1-4 alkoxy-methyl group can be referred to the groups as mentioned in R 1 to R 5 . Typical examples of the optionally substituted alkoxymethyl group include (a) a C 1-4 alkoxy-methyl group such as methoxymethyl, ethoxymethyl, propoxymethyl, isopropoxymethyl, butoxymethyl, isobutoxymethyl, s-butoxymethyl and t-butoxymethyl; (b) a carboxy-C 1-4 alkoxy-methyl group such as carboxymethoxymethyl, carboxyethoxymethyl, carboxypropoxymethyl, carboxybutoxymethyl, etc.; (c) a C 2-5 alkoxycarbonyl-C 1-4 alkoxy-methyl group such as methoxycarbonylmethoxymethyl, ethoxycarbonylmethxoymethyl, isopropoxycarbonylmethoxymethyl, 2-butoxycarbonylethoxymethyl and others; (d) a hydroxy-C 1-4 alkoxy-methyl group such as 2-hydroxyethoxymethyl, 3-hydroxypropoxymethyl and the like; (e) a C 1-4 alkoxy-C 1-4 alkoxymethyl group such as 2-methoxyethoxymethyl, 2-ethoxyethoxymethyl, 3-methoxypropoxymethyl and so on. The C 5-7 cycloalkyl group includes cyclopentyl, cyclohexyl and cycloheptyl groups. As preferred examples of the optionally substituted methylene group shown by the formula (XII), there may be mentioned, for instance, (a) the group of the formula (XII) wherein R a and R b are, the same or different, a hydrogen atom, a C 1-4 alkyl group or a C 5-7 cycloalkyl group formed with R a , R b and the adjacent carbon atom (e.g. a methylene group, a C 2-4 alkylidene group such as an ethylidene group and an isopropylidene group; a C 5-7 cycloalkylidene group such as a cyclopentylidene and a cyclohexylidene, and so on); (b) the group of the formula (XII) where R a and R b are respectively a carboxyl group or a salt thereof, an optionally substituted alkoxycarbonyl group, a hydroxymethyl group or an optionally substituted alkoxymethyl group. Specifically preferred is the group of the formula (XII) where R a and R b are, the same or different, a carboxyl group or a salt thereof, or a C 2-5 alkoxycarbonyl group. As preferred examples of R 7 and R 8 , there may be mentioned (1) a hydrogen atom, a hydroxyl group which may be protected with a protective group, or (2) R 7 is the group shown by the formula (IX): -O-R 7 , and R 8 is the group of the formula (X): -O-R 8a . Practically preferred examples of R 7 and R 8 include, a hydrogen atom, a hydroxyl group which may be protected with a protective group selected from C 1-4 alkyl group, a C 7-20 aralkyl group or a C 1-6 acyl group; or R 7 and R 8 are respectively the group of the formula (IX) -O-R 7a and the group (X) -O-R 8a , and in the optionally substituted methylene group if the general formula (XII) formed by incorporation of R 1 and R 2 where R a and R b are respectively a carboxyl group or a salt thereof, or a C 2-5 alkoxycarbonyl group. The halogen atom, the optionally substituted C 1 -C 4 alkyl group, the optionally substituted cycloalkyl group, the protective group for hydroxyl group, the optionally substituted alkoxy group, the optionally substituted cycloalkyloxy group, the optionally substituted aralkyloxy group, the optionally substituted aryloxy group, the optionally substituted C 1 -C 4 alkylthio group, the optionally substituted acyl group, the protective group for carboxyl group, the optionally substituted C 2 -C 5 alkoxy carbonyl group, the optionally substituted amino group in R 6 , R 9 and R 10 include, for example, those mentioned in R 1 to R 5 and R 7 , R 8 . As examples of the optionally substituted aralkylthio group, there may be mentioned a C 7-20 alkylthio group (for example, benzylthio, or naphthylthio group) which may be substituted with a substituent such as a C 1-4 alkyl group, a hydroxyl group, a C 1-4 alkoxy group, a nitro group, a halogen atom and others. The optionally substituted aryl group and the optionally substituted aralkyl group include, for instance, the optionally substituted C 6-16 aryl group and the optionally substituted C 7-20 aralkyl group as mentioned in the explanation of the protective group for hydroxyl group. As the substituent for the C 1 -C 4 alkyl group and the C 1 -C 4 alkoxy group, an optionally substituted amino group as mentioned above can also be employed. Typical examples of R 6 , R 9 and R 10 include a hydrogen atom, a C 1-4 alkyl group, specifically a hydrogen atom. Examples of the C 1 -C 4 alkyl group in R 11 include a C 1-4 alkyl group as mentioned in R 1 to R 5 . Methyl group and ethyl group, specifically methyl group, can advantageously be used as R 11 . As examples of the compound of the general formula (VIII) there may be mentioned, methyl=phenylmethyl= ketone (phenyl acetone); a phenylacetone derivative such as ethyl=benzyl=ketone, propyl=phenylmethyl=ketone, isopropyl=phenylmethyl=ketone, butyl=phenylmethyl=ketone, isobutyl=phenylmethyl=ketone, s-butyl=phenylmethyl=ketone, t-butyl=phenylmethyl=ketone, and so on; a derivative having a substituent on the 2-position of the phenyl group such as methyl=2-methylphenylmethyl=ketone, ethyl=2-chlorophenylmethyl=ketone, methyl=2-ethylphenylmethyl=ketone, ethyl=2-methylphenylmethyl=ketone, methyl=2-methoxyphenylmethyl=ketone, methyl=2-benzyloxyphenylmethyl=ketone, ethyl=2-benzyloxyphenylmethyl=ketone and so on; a derivative having a substituent on the 3-position of the phenyl group such as methyl=3-methylphenylmethyl=ketone, ethyl=3-chlorophenylmethyl=ketone, methyl=3-methoxycarbonyl-2-methoxyphenylmethyl=ketone, ethyl=3-methoxycarbonyl-2-methoxyphenylmethyl=ketone, methyl=2-methyl-3-aminoethoxyphenylacetone and others; a derivative substituted on the 4-position of the phenyl group such as methyl=4-methylphenylmethyl=ketone, ethyl=4-methylphenylmethyl=ketone, 4-ethylphenylmethyl=ketone, ethyl=4-ethylphenylmethyl=ketone, 4-hydroxyphenylmethyl=ketone, ethyl=4-hydroxyphenylmethyl=ketone, methyl=4-methoxyphenylmethyl=ketone, ethyl=4-methoxyphenylmethyl=ketone, methyl=4-benzyloxyphenylmethyl=ketone, ethyl-4-benzyloxyphenylmethyl=ketone, methyl=4-hydroxyethoxyphenylmethyl=ketone, methyl=4-(2-ethoxyethoxy)phenylmethyl=ketone, methyl=4-(2-dimethylaminoethoxy)phenylmethyl=ketone, methyl=4-methylthiophenylmethyl=ketone, methyl=4-benzylthiophenylmethyl=ketone, methyl=4-hydroxycarbonylphenylmethyl=ketone, methyl=4-methoxycarbonylphenylmethyl=ketone, methyl=4-carbamoylphenylmethyl=ketone, methyl=4-dimethylaminocarbonylphenylmethyl=ketone, methyl=4-benzylaminocarbonylphenylmethyl=ketone, methyl=4-aminophenylmethyl=ketone, methyl=4-acetylaminophenylmethyl=ketone, methyl=4-acetylaminomethylphenylmethyl=ketone, methyl=4-ethoxycarbonylaminophenylmethyl=ketone, methyl=4-methoxycarbonylmethylaminophenylmethyl=ketone, methyl=4-acetylphenylmethyl=ketone, methyl=4-(o-methoxyphenyl)phenylmethyl=ketone, methyl=4-(m-methoxycarbonylphenyl)phenylmethyl=ketone, methyl=4- (p-chlorophenyl)phenylmethyl=ketone, methyl=4-(p-hydroxyphenyl)phenylmethyl=ketone, methyl=4-(p-chlorophenylmethyl)phenylmethyl=ketone, methyl=4-(p-methoxyphenylmethyl)phenylmethyl=ketone, and the like; a derivative substituted with substituents on the 2,4-positions, 2,5-positions or 3,4-positions of the phenyl group such as methyl=2-methoxy-4-methoxycarbonylphenylmethyl=ketone, methyl=3,4-dimethoxyphenylmethyl=ketone, methyl=3,4-dihydroxyphenylmethyl=ketone, ethyl=3,4-dihydroxyphenylmethyl=ketone, methyl=3,4-dimethoxycarbonylphenylmethyl=ketone, ethyl=3,4-dimethoxycarbonylphenylmethyl=ketone, methyl=3-methoxy-4-methoxycarbonylphenylmethyl=ketone, methyl=3-methyl-4-methoxyphenylmethyl=ketone, methyl=3-methylamino-4-benzyloxyphenylmethyl=ketone, methyl=3-methoxycarbonyl-4-hydroxyphenylmethyl=ketone, methyl=3-chloro-4-hydroxyphenylmethyl=ketone, methyl=3-fluoro-4-methoxycarbonylphenylmethyl=ketone, methyl=3-fluoro-4-methylaminoethoxyphenylmethyl=ketone, 2-iodo-5-methoxyphenylmethyl=ketone, etc.; a derivative substituted with substituents on the 2,3,4-positions or the 2,4,5-positions of the phenyl group such as 2,3,4-trimethoxyphenylmethyl=ketone, methyl=3,5-difluoro-4-methoxyphenylmethyl=ketone, and others; a C 1-4 alkyl=(1,3- benzodioxol-5-yl)methyl=ketone such as methyl=(1,3-benzodioxol-5-yl)methyl ketone; a C 1-4 alkyl=(2,2-di-C 1-4 alkyl-1,3-benzodioxol-5-yl)methyl=ketone derivative such as methyl= (2,2-dimethyl-1, 3-benzodioxol-5-yl)methyl=ketone; a C 1-4 alkyl=[2,2-bis(C 2-5 alkoxycarbonyl)-1,3-benzodioxol-5-yl]methyl=ketone such as [dimethyl 5-(2-oxopropyl)-1,3-benzodioxole-2,2-dicarboxylate], methyl=[diethyl 5-(2-oxopropyl)-1,3-benzodioxole-2, 2-dicarboxylate], methyl=(2,2-dimethoxycarbonyl-1,3-benzodioxol-5-yl)methyl=ketone, ethyl=(2,2-dimethoxycarbonyl-1,3-benzodioxol-5-yl)methyl=ketone, methyl=(2,2-bisethoxycarbonyl-1,3-benzodioxol-5-yl)methyl=ketone and so on; a C 1-4 alkyl=[2,2-di(hydroxy-C 1-4 alkoxy-C 1-4 alkyl)-1,3-benzodioxol-5-yl]methyl=ketone such as methyl=(2,2-dihydroxyethoxymethyl-1,3-benzodioxol-5-yl)methyl=ketone; a C 1-4 alkyl=[2,2-di-(C 2-5 alkoxycarbonyl-C 1-4 alkoxy-C 1-4 alkyl)-1,3-benzodioxol-5-yl]methyl=ketone derivative such as methyl=[2,2-di-(methoxycarbonylmethoxymethyl)-1,3-benzodioxol-5-yl]methyl=ketone, ethyl=[2,2-di-(methoxycarbonylmethoxymethyl)-1,3-benzodioxol-5-yl]methyl=ketone and so on; a C 1-4 alkyl=(1,4-benzodioxin-6-yl)methyl=ketone derivative such as methyl=(1,4-benzodioxin-6-yl)methyl=ketone and the like. As preferred examples of the above compounds, there may be mentioned a C 1-4 alkyl=phenylmethyl=ketone derivative; a C 1-4 alkyl=3,4-di-C 1-4 alkoxyphenylmethyl=ketone derivative; a C 1-4 alkyl=3,4-dihydroxyphenylmethyl=ketone derivative; a C 1-4 alkyl=3,4-dihydroxyphenylmethyl=ketone derivative; a C 1-4 alkyl=[2,2-bis(C 2-5 alkoxycarbonyl)-1,3-benzodioxol-5-yl]methyl=ketone derivative; a C 1-4 alkyl=[2,2-di-(C 2-5 alkoxycarbonyl-C 1-4 alkoxy-C 1-4 alkyl)-1,3-benzodioxol-5-yl]methyl=ketone derivative. The compound shown by the general formula (XI) is a compound obtainable by a combination of the (R)-2-amino-1-phenylethanol derivative of the general formula (II) and the phenylacetone derivative of the general formula (VIII), and practically includes, for example, (a) an (R,R)-1-phenyl-2-[(2-phenyl-1-C 1-4 alkylethyl)amino]ethanol derivative, (b) an (R,R)-1-phenyl-2-[[2-(2-substituted phenyl)-1-C 1-4 alkyl-ethyl]amino]ethanol derivative, (c) an (R,R)-1-phenyl-2-[[2-(3-substituted phenyl)-1-C 1-4 alkylethyl]amino]ethanol derivative, (d) an (R,R)-1-phenyl-2-[[2-(4-substituted phenyl)-1-C 1-4 alkyl-ethyl]amino]ethanol derivative, (e) an (R,R)-1-phenyl-2-[[2-(3,4-di-substituted phenyl)-1-C 1-4 alkylethyl]amino]ethanol derivative, (f) an (R,R)-1-(2-halophenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative, (g) an (R,R)-1-(2-substituted phenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative, (h) an (R,R)-1-(3-halophenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative, (i) an (R,R)-1-(3-substituted phenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative, (j) an (R,R)-1-(4-halophenyl)-2-[(2-phenyl-1-C 1-4 alkylethyl)amino]ethanol derivative, (k) an (R,R)-1-(4-substituted phenyl)-2-[(2-phenyl-1-C 1-4 alkylethyl)amino]ethanol derivative, (l) an (R,R)-1-(2,3-dihalophenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative, (m) an (R,R)-1-(2,4-di-substituted phenyl) -2- [(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative, (n) an (R,R)-1-(3,4-di-halophenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative, (o) an (R,R)-1-(3,4-di-substituted phenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative, (p) an (R,R)-1-(3,5-di-substituted phenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative, (q) an (R,R)-1-(3,4,5-tri-substituted phenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative and so on. (a) The (R,R)-1-phenyl-2-[(2-phenyl-1-C 1-4 alkylethyl)amino]ethanol derivative include, for example, (R,R)-1-phenyl-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-phenyl-2-[(2-phenyl-1-ethylethyl)amino]ethanol, (R,R)-1-phenyl-2-[(2-phenyl-1-propylethyl)amino]ethanol, (R,R)-1-phenyl-2-[(2-phenyl-1-isopropylethyl)amino]ethanol, (R,R)-1-phenyl-2-[(2-phenyl-1-butylethyl)amino]ethanol, (R,R)-1-phenyl-2-[(2-phenyl-1-isobutylethyl)amino]ethanol, (R,R)-1-phenyl-2-[(2-phenyl-1-s-butylethyl)amino]ethanol, (R,R)-1-phenyl-2-[(2-phenyl-1-t-butylethyl) amino]ethanol and the like. (b) Examples of the (R,R)-1-phenyl-2-[[2-(2-substituted phenyl)-1-C 1-4 alkyl-ethyl]amino]ethanol derivative include (R,R)-1-phenyl-2-[[2-(2-chlorophenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(2-methylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(2-methoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(2-benzyloxyphenyl)-1-methylethyl]amino]ethanol, and others. (c) As the (R,R)-1-phenyl-2-[[2-(3-substituted phenyl)-1-C 1-4 alkyl-ethyl]amino]ethanol derivative, there may be mentioned, for example, (R,R)-1-phenyl-2-[[2-(3-methylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(3-methoxyphenyl)-1-methylethyl] amino]ethanol, (R,R)-1-phenyl-2-[[2-(3-methylaminoethoxyphenyl)-1-methylethyl]amino]ethanol and so on. (d) The (R,R)-1-phenyl-2-[[2-(4-substituted phenyl)-1-C 1-4 alkyl-ethyl]amino]ethanol derivative includes, for instance, (R,R)-1-phenyl-2-[[2-(4-phenylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(4-methylphenyl]-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(4-ethylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(4-benzyloxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(4-hydroxyethoxyphenyl)-1-methylethyl]amino)ethanol, (R,R)-1-phenyl-2-[[2-(4-dimethylaminomethoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(4-methylthiophenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(4-benzylthiophenyl)-1-methylethyl]amino] ethanol, (R,R)-1-phenyl-2-[[2-(4-hydroxycarbonylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[(2-(4-methoxycarbonylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(4-carbamoylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(4-dimethylaminocarbonylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(9-benzylaminocarbonylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(4-acetylaminocarbonylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(4-acetylaminomethylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(4-acetylphenyl)-1-methylethyl]amino]ethanol and others. (e) Examples of the (R,R)-1-phenyl-2-[[2-(3,4-di-substituted phenyl)-1-C 1-4 alkyl-ethyl]amino]ethanol derivative include (R, R) -1-phenyl-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-(3,4-dimethoxyphenyl)-1-ethylethyl]amino]ethanol, (R, R)-1-phenyl-2-[[2-(3,4-dimethoxyphenyl)-1-propylethyl]amino]ethanol, (R,R)-1-phenyl-2-[[2-[3,4-(bismethoxycarbonylmethoxy)methylenedioxyphenyl]-1-methylethyl]amino]ethanol and the like. (f) As the (R,R)-1-(2-halophenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative, there may be mentioned, for instance, (R,R)-1-o-chlorophenyl-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(2-chlorophenyl)-2-[[2-(2-chlorophenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-chlorophenyl)-2-[[2-(2-methylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-chlorophenyl)-2-[[2-(2-methoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol, (R, R)-1-(2-fluorophenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(2-fluorophenyl)-2-[[2-(2-chlorophenyl)-1-methylethyl]amino]ethanol, (R, R)-1-(2-fluorophenyl)-2-[[2-(2-methylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-fluorophenyl)-2-[[2-(2-methoxyphenyl)-1-methylethyl]amino]ethanol, (R, R)-1-(2-fluorophenyl)-2-[[2-(3, 4-dimethoxyphenyl) -1-methylethyl]amino]ethanol, etc. (g) Examples of the (R,R)-1-(2-substituted phenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative include (R,R)-1-(2-methylphenyl)-2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(2-methylphenyl)-2-[[2-(2-chlorophenyl)-1-methylethyl]amino]ethanol, (R, R)-1-(2-methylphenyl)-2-[[2-(2-methylphenyl)-1-methylethyl]amino]ethanol, (R, R)-1-(2-methylphenyl) -2-[[2-(2-methoxyphenyl)-1-methylethyl]amino]ethanol, (R, R)-1-(2-methylphenyl) -2- [[2-(3,4-dimethoxyphenyl) -1-methylethyl]amino]ethanol, (R,R)-1-(2-hydroxyphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(2-hydroxyphenyl)-2-[[2-(2-chlorophenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-hydroxyphenyl)-2-[[2-(2-methylphenyl)-1-methylethyl]amino]ethanol, (R, R)-1-(2-hydroxyphenyl)-2-[[2-(2-methoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-hydroxyphenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol, (R, R)-1-(2-methoxyphenyl)-2-[(2-phenyl-2-methylethyl]amino]ethanol, (R,R)-1-(2-methoxyphenyl)-2-[[2-(2-chlorophenyl)-1-methylethyl]amino)ethanol, (R, R)-1-(2-methoxyphenyl)-2-[[2-(2-methylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-methoxyphenyl)-2-[[2-(2-methoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-methoxyphenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-benzyloxyphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(2-benzyloxyphenyl)-2-[[2-(2-chlorophenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-benzyloxyphenyl)-2-[[2-(2-methylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-benzyloxyphenyl)-2-[[2-(2-methoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-benzyloxyphenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-benzylcarbonylphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol and so on. (h) As the (R,R)-1-(3-halophenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative, there may be mentioned, for example, (R,R)-1-(3-chlorophenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(2-chlorophenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(2-methylphenyl]-1-methylethyl]amino]ethanol, (R,R)-1- (3-chlorophenyl)-2-[[2- (2-methoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(2-benzyloxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(3-methylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(3-methoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(3-methylaminoethoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl) -2-[[2-(4-methylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-ethylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-phenylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-hydroxyphenyl)-1-ethylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-benzyloxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-hydroxyethoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-dimethylaminomethoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-methylthiophenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-benzylthiophenyl)-1-methylethyl]amino]ethanol, (R, R)-1-(3-chlorophenyl)-2-[[2-(4-hydroxycarbonylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-methoxycarbonylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-carbamoylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-dimethylaminocarbonylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-benzylaminocarbonylphenyl)-1-methylethyl] amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-acetylaminocarbonylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-acetylaminomethylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(4-acetylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-ethylethyl]amino]ethanol, (R, R)-1- (3-chlorophenyl)-2-[[2-[3,4-(bismethoxycarbonylmethoxy)methylenedioxyphenyl]-1-methylethyl]amino]ethanol, (R,R)-1-(3-chlorophenyl)-2-[[2-[3,4-(bismethoxycarbonylmethoxy) methylenedioxyphenyl]-1-ethylethyl]amino]ethanol, (R,R)-1-(3-fluorophenyl)-2-[(2-phenyl-1-methylethyl) amino]ethanol and so on. (i) As examples of the (R,R)-1-(3-substituted phenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative, there may be mentioned (R,R)-1-(3-methylphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R, R)-1-(3-methylphenyl)-2-[[2-(2-chlorophenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-methylphenyl)-2-[[2-(2-methoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-methylphenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-hydroxyphenyl)-2-[(2-phenyl)-1-methylethylamino]ethanol, (R,R)-1-(3-trifluoromethylphenyl)-2-[(2-phenyl)-1-methylethylamino]ethanol, (R,R)-1-(3-trifluoromethylphenyl)-2-[[2-(2-chlorophenyl)-1-methylethyl] amino]ethanol, (R,R)-1-(3-trifluoromethylphenyl)-2-[[2-(2-methylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-trifluoromethylphenyl)-2-[[2-(2-methoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-trifluoromethylphenyl)-2-[[2-(4-benzylphenyl)-1-methylethyl] amino]ethanol, (R,R)-1-(3-trifluoromethylphenyl)-2-[(2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-trifluoromethylphenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-ethylethyl]amino]ethanol, etc. (j) The (R,R)-1-(4-halophenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative includes, for instance, (R, R)-1-(4-chlorophenyl)-2-[(2-phenyl-1-methylethyl]amino]ethanol, (R,R)-1-(4-chlorophenyl)-2-[(2-(2-chlorophenyl)-1-methylethyl]amino]ethanol, (R, R)-1-(4-chlorophenyl)-2-[(2-(2-methylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(4-chlorophenyl)-2-[[2-(2-methoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(4-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol and the like. (k) Examples of the (R,R)-1-(4-substituted phenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative include, (R,R)-1-(4-methylphenyl)-2-[(2-phenyl-1-methylethyl]amino]ethanol, (R,R)-1-(4-methylphenyl)-2-[[2-(2-chlorophenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(4-methylphenyl)-2-[[2-(2-methoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(4-methylphenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(4-hydroxyphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(4-hydroxyphenyl)-2-[(2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(4-trifluoromethylphenyl)-2-[(2-phenyl-1-methylethyl]amino]ethanol, (R,R)-1-(4-trifluoromethylphenyl)-2-[[2-(2-chlorophenyl)-1-methylethyl]amino] ethanol, (R, R)-1-(4-trifluoromethylphenyl) -2-[[2-(2-methylphenyl)-1-methylethyl]amino]ethanol, (R, R)-1-(4-trifluoromethylphenyl)-2-[[2-(2-methoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(4-trifluoromethylphenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(4-methoxyphenyl)-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethanol and so on. (l) As the (R,R)-1-(2,3-di-substituted phenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative, there may be mentioned, for instance, (R,R)-1-(2-fluoro-3-chlorophenyl)-2-[(2-phenyl-1-methylethyl]amino]ethanol, (R,R)-1-(2-fluoro-3-chlorophenyl)-2-[[2-(2-chlorophenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-fluoro-3-chlorophenyl)-2-[[2-(2-methylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-fluoro-3-chlorophenyl)-2-[[2-(2-methoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-fluoro-3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(2-fluoro-3-chlorophenyl)-2-[[2-[3,4-(bismethoxycarbonylmethoxy) methylenedioxyphenyl]-1-methylethyl]amino]ethanol, (R, R)-1-(2-chloro-3-hydroxyphenyl)-2-[(2-phenyl-1-ethylethyl]amino]ethanol and others. (m) The (R,R)-1-(2,4-di-substituted phenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative includes, for example, (R,R)-1-(2-chloro-4-hydroxyphenyl)-2-[(2-phenyl-1-methylethyl]amino]ethanol, (R,R)-1-(2-chloro-4-benzyloxyphenyl)-2-[(2-phenyl-1-methylethyl]amino]ethanol, and the like. (n) Examples of the (R,R)-1-(3,4-di-halophenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative include (R,R)-1-(3,4-dichlorophenyl)-2-[(2-phenyl-1-methylethyl]amino]ethanol, (R,R)-1-(3,4-dichlorophenyl) -2-[[2-(2-chlorophenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3,4-dichlorophenyl)-2-[[2-(2-methylphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3,4-dichlorophenyl) -2-[[2-(2-methoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3,4-dichlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1- methylethyl]amino]ethanol, (R,R)-1-(3,4-dichlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-ethylethyl]amino]ethanol, (R,R)-1-(3,4-dichlorophenyl)-2-[[2-[3,4-(bismethoxycarbonylmethoxy)methylenedioxyphenyl]-1-methylethyl]amino]ethanol and so on. (o) As the (R,R)-1-(3,4-di-substituted phenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative, there may be mentioned, for instance, (R,R)-1-(3,4-dihydroxyphenyl)-2-[(2-phenyl-1-methylethyl) amino]ethanol, (R,R)-1-(3,4-dihydroxyphenyl)-2-[[2-(3,4-dihydroxyphenyl)-1-methylethyl] amino]ethanol, (R,R)-1-(3,4-dihydroxyphenyl)-2-[(2-phenyl-1-ethylethyl)amino]ethanol, (R,R)-1-(3,4-dimethoxyphenyl)-2-[(2-phenyl-1-methylethyl)amino] ethanol, (R,R)-1-(3-fluoro-4-methoxyphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-[3-(2-hydroxyethoxy)-4-(t-butoxy)phenyl]-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(3-acetylamino-4-hydroxyphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(3-acetylamino-4-methoxyphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(3-methylthio-4-hydroxyphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(3-hydroxymethyl-4-hydroxyphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(3-methoxycarbonyl-4-hydroxyphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(3-methoxycarbonyl-4-cyclohexyloxyphenyl)-2-[(2-phenyl-1-methylethyl) amino]ethanol, (R,R)-1-(3-carbamoyl-4-hydroxyphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-[3-hydroxymethylcarbonylamino-4-(4-methoxyphenylmethyl)phenyl]-2-[(2-phenyl-1-methylethyl) amino]ethanol, etc. (p) As examples of the an (R,R)-1-(3,5-di-substituted phenyl)-2-[(2-phenyl-1-C 1-4 alkylethyl)amino]ethanol derivative, (R,R)-1-(3,5-dihydroxyphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(3,5-dibenzyloxyphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(3,5-di-t-butoxycarbonylphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, and the like. (q) The (R,R)-1-(3,4,5-tri-substituted phenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative includes, for example, (R,R)-1-(3,5-dichloro-4-methylaminophenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R, R)-1-(4-amino-3-bromo-5-fluorophenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(4-benzyloxy-3-chloro-5-methoxyphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(4,5-dihydroxy-3-methylphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol and others. Typical examples of the compounds mentioned above include an (R,R)-1-phenyl-2-[(2-phenyl-1-C 1-4 alkylethyl)amino]ethanol derivative such as (R,R)-1-phenyl-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-phenyl-2-[(2-phenyl-1-ethylethyl]amino]ethanol and the like; (R,R)-1-phenyl-2-[[2-[3,4-di-substituted (e.g. di-C 1-4 alkoxy)-phenyl]-1-C 1-4 alkylethyl]amino]ethanol derivative such as (R,R)-1-phenyl-2-[(2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol; an (R,R)-1-(3-halophenyl)-2-[(2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative such as (R,R)-1-(3-chloro)phenyl-2-[(2-phenyl-1-methylethyl) amino]ethanol; an (R,R)-1-(3-halophenyl)-2-[[2-[3,4-di-substituted (e.g. 3,4-di-C 1-4 alkoxy)-phenyl]-1-C 1-4 alkyl-ethyl]amino]ethanol derivative such as (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol; an (R,R)-1-(3-substituted phenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol derivative such as (R,R)-1-(3-methylphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol, (R,R)-1-(3-trifluoromethylphenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol; an (R,R)-1-(3-substituted phenyl)-2-[[2-f3,4-di-substituted (e.g. 3,4-di-C 1-4 alkoxyl-phenyl]-1-C 1-4 alkyl-ethyl]amino]ethanol derivative such as (R,R)-1-(3-methylphenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol, (R,R)-1-(3-trifluoromethylphenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol and the like; an (R,R)-1-(4-substituted phenyl)-2-[(2-phenyl-1-C 1-4 alkylethyl)amino]ethanol derivative such as (R,R)-1-(4-chlorophenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol; an (R,R)-1-(-4-halophenyl)-2-[[2-[3,4-di-substituted (e.g. 3,4-di-C 1-4 alkoxy)phenyl]-1-C 1-4 alkylethyl]amino]ethanol derivative such as (R,R)-1-(4-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol; an (R,R)-1-(3,4-di-halophenyl)-2-[[2-phenyl-1-C 1-4 alkyl-ethyl)amino]ethanol derivative such as (R,R)-1-(3,4-dichlorophenyl)-2-[(2-phenyl-1-methylethyl)amino]ethanol; an (R,R)-1-(3,4-dihalophenyl)-2-[[2-[3,4-di-substituted (e.g. 3,4-di-C 1-4 alkoxy)phenyl]-1-C 1-4 alkyl-ethyl]amino] ethanol derivative such as (R,R)-1-(3, 4-dichlorophenyl)-2-[[2-(3, 4-dimethoxyphenyl)-1-methylethyl]amino] ethanol and so on. In this method, the phenylacetone derivative of the general formula (VIII) used as a raw material can easily be obtained by a conventional method, for example, dry distillation of a mixture of an acetic acid salt such as an acetic acid with an alkaline earth metal (e.g. calcium acetate and barium acetate) and a phenylacetic acid salt corresponding to the compound of the general formula (VIII) such as a phenyl acetic acid salt with an alkaline earth metal salt (for instance, calcium phenylacetate, barium phenylacetate, etc.) or others (see Org. Synth., Coll. Vol. II, 389 (1943), etc.) The method of the present invention is characterized by comprising a reaction of the (R)-2-amino-1-phenylethanol compound of the general formula (II) or a salt thereof with the compound of the general formula (VIII) (phenylacetone derivative) and a reducing reaction of the reaction product of the above reaction. The (R,R)-1-phenyl-2-[[2-(phenyl)-1-methylethyl]amino]ethanol derivative of the general formula (XI) obtained in the method includes a corresponding salt. The reducing reaction may for example be conducted using a reducing agent. The reaction may also be carried out in the presence of a catalyst for catalytic reduction. The reaction may be carried out, for instance, by (1) a method which comprises dehydrating-condensing the (R)-2-amino-1-phenylethanol derivative of the general formula (II) or a salt thereof and the compound of the general formula (VIII), and then hydrogenating the resultant compound (hereinafter refereed to as stepwise method), (2) a method of allowing the (R)-2-amino-1-phenylethanol compound of the general formula (II) or a salt thereof to react with the compound of the general formula (VIII), and hydrogen in the presence of a catalyst for catalytic reduction (hereinafter referred to as one-pot method), and others. According to the reductive aminating method as above using an optically active 2-amino-1-phenylethanol compound or a salt thereof and a phenylacetone derivative, the products are only two species of optical isomers. Further, when hydrogenation is conducted using hydrogen in the presence of a catalyst for catalytic reduction, the diastereomer-ratio can be increased significantly and the object optical isomer can be advantageously obtained. Moreover, such a method using a catalyst for catalytic reduction is suitable for commercial production, since the object compound can be isolated only by filtrating off the catalyst for catalytic reduction and distilling off a solvent, and thus after-treatment is easy. The stepwise method (1) is illustrated hereinbelow. The stepwise method (1) is characterized in that an imine-form or an enamine-form can certainly or reliably be obtained by conducting dehydrating-condensation before hydrogenation, and the conversion ratio of the raw materials to the object compound can be increased, thus the purification can be carried out easily. The dehydrating-condensation of the 2-amino-1-phenylethanol compound of the general formula (II) or a salt thereof and the phenylacetone derivative of the general formula (VIII) can be carried out by a conventional manner, for instance, using an inert solvent which can be boiled azeotropically with water, removing the water out of the reaction system by means of, for example, a trap means such as Dean -Stark trap. The solvent is not restricted as far as being inert and boiling with water azeotropically, and includes, for instance, organic solvents such as hydrocarbons including aromatic hydrocarbons (e.g. benzene, toluene, xylene, ligroin, petroleum ether, etc.) and aliphatic hydrocarbons (for example, pentane, hexane, heptane, octane, and others) as well as alcohols including lower alcohols (e.g. a C 1-4 alcohol such as methanol, ethanol, propanol, t-butanol); alicyclic hydrocarbons such as cyclohexane, methylcyclohexane, etc.; halogenated hydrocarbons such as carbon tetrachioride, chloroform, dichloromethane and 1/2-dichloroethane; ethers such as diethyl ether, dibutyl ether, dioxane, tetrahydrofuran and others; ketones such as acetone, methyl ethyl ketone and the like; esters such as methyl acetate and ethyl acetate. The dehydrating-condensation may also be conducted by using a solvent, for example, an inert solvent which is capable of boiling with water azeotropically and removing water out of the reaction system with distilling off the solvent. Such solvent includes, for example, organic solvents such as lower alcohols (e.g. a C 1-4 alcohol such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, t-butanol, etc.) as well as aromatic hydrocarbons and aliphatic hydrocarbons mentioned above. The reaction may be carried out in the presence of an acid catalyst. As such an acid, acids used in the following one-pot method (2) can be employed. The ratio of the (R)-2-amino-1-phenylethanol compound of the general formula (II) or a salt thereof relative to the phenylacetone derivative of the general formula (VIII) is usually such that the former/the latter equals about 0.5 to 2.0 (molar ratio) and preferably about 0.8 to 1.2 (molar ratio). As the reducing agent, there may be mentioned, for example, a metal hydride such as sodium cyanoborohydride and sodium borohydride, hydrogen and others. Hydrogen may usually be employed in combination with a catalyst for catalytic reduction. Use of hydrogen as the reducing agent can render the object (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative to be produced preferently among the two species of diastereomers by asymmetric induction. The catalyst for catalytic reduction include, for instance, a nickel catalyst such as Raney-nickel catalyst; a platinum group catalyst including a platinum catalyst such as platinum carbon, platinum black, platinum oxide (e.g. Adams catalyst), etc., a palladium catalyst, a rhodium catalyst, a ruthenium catalyst such as ruthenium carbon, ruthenium oxide and ruthenium black, and a rhenium catalyst. These catalysts can be employed singly or in combination. Preferred catalyst includes, for example, a platinum catalyst and a ruthenium catalyst. Among them a platinum catalyst, specifically platinum oxide, can advantageously be used. The amount of the catalyst for catalytic reduction can be selected from a range with regard to the reaction rate and economic factors, and is, generally, about 0.01 to 20 parts by weight, preferably about 0.01 to 10 parts by weight, more preferably about 0.01 to 5 parts by weight (e.g 0.5 to 5 parts by weight), and specifically 0.5 to 3 parts by weight relative to 100 parts by weight of the compound of the general formula (II). The reaction temperature is depending on the species or amount of the raw materials, the species of the catalyst, the pressure condition and other factors, and is usually about 0 to 100'C, preferably about 10 to 80°C and more preferably about 10 to 60°C. The reaction may be carried out under atmospheric condition or under pressure. The reaction pressure may range, usually, about from 1 to 100 atm, preferably about from 1 to 20 atm. The reaction time may be selected from a shorter time (for example about 10 minutes to 10 hours) under pressure, and about 1 to 48 hours at atmospheric condition. The hydrogenation can be conducted in an inert solvent. The solvent includes, for instance, organic solvents including alcohols such as C 1-4 alcohols (e.g. methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, t-butanol, etc.); aromatic hydrocarbons such as benzene, toluene, xylene, ethylbenzene, petroleum ether, and others; aliphatic hydrocarbons such as pentane, hexane, heptane, octane, and the like; alicyclic hydrocarbons such as cyclohexane, methylcyclohexane, cycloheptane, etc.; halogenated hydrocarbons such as chloroform, dichloromethane, 1,2-dichloroethane and so on; ethers such as diethyl ether, diisopropyl ether, dibutyl ether, dioxane, tetrahydrofuran and the like; esters such as methyl acetate, ethyl acetate, isopropyl acetate and others. Such solvents can be employed independently or in corporation. The explanation of the one-pot method (2) is illustrated hereinbelow. According to the one-pot method (2), the (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative of the general formula (XI) can be obtained by allowing the (R)-2-amino-1-phenylethanol compound of the general formula (II) or a salt thereof to react with the phenylacetone derivative of the general formula (VIII) and hydrogen in the presence of a catalyst for catalytic reduction. The reaction may be conducted in the absence of an acid, but the reaction can be proceeded advantageously in the presence of an acid. Hydrogenation in the presence of an acid where the acid acts as a catalyst can increase the conversion ratio of the raw materials to the object compound, thus the object compound can be purified easily or readily. The acid may be whichever of an inorganic acid or an organic acid. Examples of the inorganic acid include hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, boric acid, carbonic acid and the like. Typical example of the inorganic acid include hydrochloric acid. As the organic acid, there may be mentioned, for example, saturated aliphatic monocarboxylic acids such as formic acid, acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid, pivalic acid and O-benzoyl glycolic acid; saturated aliphatic dicarboxylic acids such as oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimeric acid, suberic acid and others; unsaturated aliphatic carboxylic acids such as acrylic acid, propiolic acid, methacrylic acid, crotonic acid, isocrotonic acid, maleic acid, fumaric acid, citraconic acid, mesaconic acid, and so on; aliphatic hydroxycarboxylic acids such as glycolic acid, lactic acid, malic acid, tartaric acid, hydroxybutyric acid, hydroxyacrylic acid, glyceric acid, tartoronic acid, citric acid and others; carbocyclic carboxylic acids such as camphoric acid, benzoic acid, phthalic acid, isophthalic acid, terephthalic acid, naphthoic acid, o-chlorobenzoic acid, m-chlorobenzoic acid, p-chlorobenzoic acid, o-toluic acid, m-toluic acid, p-toluic acid, 2,5-dimethylbenzoic acid, 3,4-dimethylbenzoic acid, 3,5-dimethylbenzoic acid, 2,4,6-trimethylbenzoic acid, o-methoxybenzoic acid, m-methoxybenzoic acid, p-methoxybenzoic acid, o-aminobenzoic acid, m-aminobenzoic acid, p-aminobenzoic acid, vanilic acid, veratoric acid, cinnamic acid, 3,4-dihydroxycinnamic acid, 3,4-dimethoxycinnamic acid, benzilic acid, 3-phenylpropionic acid and the like; aromatic hydroxycarboxylic acids such as salicylic acid, m-hydroxybenzoic acid, p-hydroxybenzoic acid, gallic acid, tropic acid and so on; heterocyclic carboxylic acids such as nicotinic acid and isonicotinic acid; amino acids which may be protected on the amino group with a protective group (for example, glycine, N-(t-butoxycarbonyl)alanine and the like); sulfonic acids such as benzenesulfonic acid, p-toluenesulfonic acid, 2,5-dimethylbenzenesulfonic acid, 2,4,6-trimethylbenzenesulfonic acid, methanesulfonic acid and others. As the acid, an acid whereby in the reaction, an adduct having high solubility to the solvent can be selected from the above exemplified acids according to the species of the solvent. Among the inorganic acids, preferred is hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid and boric acid, and typically hydrochloric acid, sulfuric acid and nitric acid. Especially, hydrochloric acid can advantageously be employed. As the organic acid, favorable includes, for instance, a saturated aliphatic monocarboxylic acid, a saturated aliphatic dicarboxylic acid, an unsaturated aliphatic carboxylic acid, a sulfuric acid and the like. More preferred is a saturated aliphatic monocarboxylic acid, a saturated aliphatic dicarboxylic acid, an unsaturated aliphatic carboxylic acid. A C 1-4 carboxylic acid such as formic acid, acetic acid and propionic acid can advantageously be employed. The using amount of the acid may be selected from a wide range depending on the reaction rate and other factors, and is, for instance, relative to 100 parts by weight of the compound of the general formula (II), about 0.1 to 80 parts by weight, preferably about 0.1 to 50 parts by weight (e.g. about 0.1 t 10 parts by weight) and more preferably about 0.5 to 10 parts by weight (for instance, about 0.5 to 5 parts by weight). The hydrogenation in the one-pot method (2) can be carried out with the use of a similar reducing agent, catalyst for catalytic reduction, reaction solvent and others under a similar reaction conditions as in the hydrogenation of the stepwise method (1). According to the method which comprises a reaction of the compound of the general formula (II) or a salt thereof with the compound of the general formula (VIII) and a reducing reaction of the resultant product, the object compound, that is, the (R,R)-1-phenyl-2-[[2-(phenyl)-1-alkylethyl]amino]ethanol derivative can efficiently be obtained with high selectivity. Further, the (R)-2-amino-1-phenylethanol compound of the general formula (II) and the compound of the general formula (VIII) used as raw materials are both easy to handle or treat and obtainable conveniently. Furthermore, among two of the raw materials, the phenylacetone derivative is not necessary optically active, thus the production process is expedient. The (R,R)-1-phenyl-2-[[2-(phenyl)-1-alkylethyl]amino]ethanol derivative having high optical purity can easily or readily obtained by subjecting the product (R,R)-1-phenyl-2-[[2-(phenyl)-1-alkylethyl]amino]ethanol derivative of the general formula (XI) to purification, if necessary after adjusting the pH of the reaction mixture, such as extraction with an organic solvent, vacuum concentration, column chromatography, distillation, crystallization and recrystallization. When the corresponding (R,S)-isomer, that is a compound of the general formula (XIII) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 and Z have the same meanings as defined above, is by-produced, the object (R,R)-isomer can efficiently and selectively be recovered by adding an acid to the reaction products and subjecting the resultant salt to fractional crystallization. The acid includes an inorganic acid and organic acid. Examples of the inorganic acid and the organic acid include the inorganic acids and the organic acids (including optically active organic acids) as mentioned above. The acids can be employed independently or in combination. Preferred examples of the inorganic acid include hydrochloric acid, and preferred of the organic acid includes, for instance, a carbocyclic carboxylic acid, an amino acid which may be protected on the amino group with a protective group, a sulfonic acid and the like. Utilization of such acid can reduce the content of an impurity, thus the (R,R)-isomer having higher optical purity can be obtained. In case of a mixture of the compound of the general formula (XI) wherein R 1 , R 2 , R 3 , R 5 , R 6 , R 9 , R 10 are respectively a hydrogen atom, R 11 is a methyl group, R 4 is chlorine atom, R 7 and R 8 are respectively a methoxy group, and the corresponding (R,S)-isomer of the general formula (XIII), an organic acid, especially an optionally substituted 2-alkylphenylpropionic acid such as (R)- or (S)-2-(2,5-dimethylphenyl)propionic acid, or a mixture of these enantiomers, and (R)-(-)- or (S)-(+)-2-(2,4,6-trimethylphenyl)propionic acid or a mixture of these enantiomers can advantageously be used. By using these acids, the (R,R)-isomer can selectively be recovered efficiently. The proportion of the acid may be selected from a broad range depending on the species of the acid, and is, usually, about 0.5 to 2 gram equivalents, preferably about 0.5 to 1.5 gram equivalents and more preferably about 0.5 to 1.3 gram equivalents relative to 1 mole of the total of the (R,R)-isomer of the general formula (XI) and (R,S)-isomer of the general formula (XIII). The acid is frequently used in a proportion of about 0.8 to 1.2 gram equivalents and more preferably about 0.9 to 1.1 gram equivalents relative to 1 mole of the total of the mixture of the (R,R)-isomer and the (R,S)-isomer. After formation of the salt, if required, an base may be added. The base includes inorganic bases and organic bases. Examples of the inorganic bases include alkali metal hydroxides such as sodium hydroxide, potassium hydroxide and lithium hydroxide; alkaline earth metal hydroxides such as magnesium hydroxide, calcium hydroxide and barium hydroxide; alkali metal carbonates such as sodium carbonate, potassium carbonate and lithium carbonate; alkaline earth metal carbonate such as magnesium carbonate, calcium carbonate and barium carbonate; alkali metal hydrogencarbonates such as sodium hydrogencarbonate and potassium hydrogencarbonate. The organic bases include, for example, metal alkoxides such as alkali metal alkoxides (for example, a sodium or potassium C 1-4 alkoxide such as sodium methoxide, sodium ethoxide, sodium propoxide, sodium butoxide, potassium methoxide, potassium ethoxide, potassium propoxide and potassium butoxide, etc.); primary amines such as an aliphatic primary amine including a monoalkylamine (e.g. a C 1-8 alkylamine such as methylamine, ethylamine, propylamine, butylamine, etc..) and an aromatic primary amine (e.g. aniline, toluidine, benzylamine, naphthylamine etc.); secondary amines such as an dialkylamine (e.g. a di-C 1-8 alkylamine such as dimethylamine, diethylamine, dipropylamine, diisopropylamine, dibutylamine, diisobutylamine, di-s-butylamine, di-t-butylamine, etc.), an aromatic secondary amine (for example, N-methylaniline, N-ethylaniline, dibenzylaniline, diphenylamine and the like), and cyclic amines such as pipecoline, piperidine, morpholine, pyrrolidine, etc.; tertiary amines such as a trialkylamine (e.g. a tri-C 1-8 alkylamine such as trimethylamine, triethylamine, tripropylamine, tributylamine, etc.), N,N-di-substituted alkanolamines such as N,N-di-C 1-4 alkyl alkanolamine (e.g. N,N-dimethylethanolamine and the like), N,N-dimethylaniline, N,N-diethylaniline, 4-dimethylaminopyridine, triphenylamine, tribenzylamine, N-methylmorpholine, N-methylpiperidine and others; basic nitrogen-containing heterocyclic compounds such as pyridine, picoline, quinoline, and others. These bases can be employed singly or in combination. Typically preferred examples of the base include a tertiary amine, specifically an aliphatic tertiary amine. A tri-C 1-8 alkylamine can preferably or advantageously be used among them. The adding amount of the base may be selected with regard to the amount of the (R,R)-isomer of the general formula (XI) or other factors, and is, for example, relative to 1 mole of the total amount of the (R,R)-isomer and the (R,S)-isomer, about 0.05 to 0.8 gram equivalent, preferably about 0.05 to 0.6 gram equivalent (for instance, about 0.05 to 0.5 gram equivalent) and more preferably about 0.1 to 0.5 gram equivalent. Probably because the (R,R)-isomer has a higher basicity than the (R,S)-isomer, the addition of a base may render the (R,S)-isomer to be liberated selectively, thus the (R,R)-isomer having high optical purity can be obtained efficiently. The reaction temperature is depending on the species of the (R,R)-isomer and (R,S)-isomer, and the species of the solvent, and crystals of the object compound can be obtained, for example, by heating the mixture to the neighborhood of the boiling point of the solvent to be dissolved, and (a) cooling to room temperature by leaving to cool, or (b) cooling to room temperature to about -10°C with preventing from formation of an oil. When the melting point of the compound is lower than the boiling point of solvent, formation of the salt may preferably be carried out at a temperature lower than the melting point of the compound. The formation of the salt and fractional crystallization may be conducted in an inert solvent. As the solvent, there may be mentioned the lower alcohols, aromatic hydrocarbons, aliphatic hydrocarbons, alicyclic hydrocarbons, halogenated hydrocarbons, ethers, esters and others as exemplified in the hydrogenation. Such solvents can be employed separately or in association. Typical examples of the solvent include esters (e.g. ethyl acetate, etc.), lower alcohols (for instance, methanol, ethanol, isopropyl alcohol, and the like), a mixture of an ester and a lower alcohol (for instance, ethyl acetate-methanol mixed solvent, ethyl acetate-ethanol mixed solvent, etc.), a mixture of a lower alcohol and an ether (for example, isopropyl alcohol-diisopropyl ether mixed solvent and the like). Ethyl acetate, isopropyl alcohol, isopropyl alcohol-diisopropyl ether mixed solvent, and others can advantageously be employed. The (R, R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative and a salt thereof thus obtained can selectively react with the β 3 -receptor in vivo to decrease or reduce blood sugar significantly and to remarkably restrain or suppress obesity. The pharmacological activity in the (R,R)-isomer is extremely higher than those in the other optical isomers. (R,R)-[disodium 5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate] shows, for example, a higher activity than the corresponding (S,S)-form by a factor of 47 (see the above-mentioned U.S. Patent). When the corresponding (S)-form is used instead of the (R)-2-amino-1-phenylethanol derivative in the reaction, the object compound (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative can hardly be produced. Further, use of the racemic 2-amino-1-phenylethanol derivative produces the objective compound only with a low yield, and 4 species of optical isomers are produced, thus an isolating process for isolation and removal of a by-produced optical isomers will be complicated. As described above, the (R)-2-amino-1-phenylethanol derivative used in the present invention is remarkably usable and effective intermediate to selectively obtain the (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative efficiently with a high yield, thus the (R)-form is remarkably more usable than the corresponding (S)-form and the racemic form. Further, the (R)-2-amino-1-phenylethanol derivative, differing from the (R)-1-methyl-2-phenylethylamine derivative conventionally used as the intermediate, does not have an antihypnotic or arousal action, therefore is easy to handle or treat and suited for a use in commercial production. R 7 , R 8 or the both of the compound of the general formula (XI) can be converted from one substituent to another by a conventional manner. As such a manner, for example, (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative where R 7 and R 8 are both methoxy groups can easily be converted to the compound where R 7a and R 8a together form the group shown by the formula (XII) in accordance with a method shown by the following scheme. In the following scheme, only the moiety of the phenyl group where R 7 and R 8 are substituted on is illustrated for convenience. In the scheme, R 12 , R 13 and R 14 respectively represent an optionally substituted alkyl group; X a and X b separately represent a halogen atom; and R 6 , R 9 , R 10 and R 11 have the same meanings as defined above. In the reaction, a compound having a group of the formula (XII) where R a and R b are both optionally substituted alkoxycarbonyl groups, can easily be prepared by allowing a demethylating agent such as BBr 3 to react with the compound of the general formula (XI'a) where R 1 and R 2 are both methyl groups for demethylation, and allowing a dihalomalonic acid ester shown by the formula (XIX) such as diethyl dibromomalonate to react with the demethylated compound in the presence of a base such as potassium carbonate. The resultant compound can be introduced to a compound having the group of the formula (XI'd) where R a and R b are both hydroxyl groups by using a reducing agent such as lithium borohydride. When allowing an alkyl halide of the formula (XX) to react with the resulting compound in the presence of a base such as sodium hydride, a compound having the group of the formula (XII) where R a and R b are respectively an optionally substituted alkoxymethyl group can be prepared. Further, hydrolysis of the compound (XI'c) having the group of the formula (XII) where R a and R b are respectively an optionally substituted alkoxycarbonyl group, in accordance with a conventional hydrolyzing method such as alkali hydrolysis using an alkali such as an alkali metal hydroxide (e.g. sodium hydroxide) or the like can easily or readily afford a compound having the group of the formula (XII) wherein R a and R b are, the same or different, a carboxyl group or a salt thereof. With regard to the method, the disclosures and descriptions in the above mentioned U.S. Patent 5,061,727 and J. Med. Chem., 35 , 3081 (1992) can be referred and incorporated with the present specification. The (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative or a salt thereof can advantageously be used, as intact or, where necessary, subjected to a suitable chemical modification, as a medicament such as an anti-obesity agent and an anti-diabetic agent. The processes for such chemical modification may be referred to the descriptions and disclosures in, for example, the above-mentioned U.S. Patent 5,061,727, J. Med. Chem., 35 , 3081 (1992) and "Protective groups in Organic Synthesis" (T. W. Greene, A Wiley-Interscience Publication, John Wiley & Sons (1981)). The production of the (S)-2-amino-1-phenylethanol derivative of the general formula (XV) is illustrated as follows. As examples and preferred R 1 to R 5 of the general formula (XV), there may be mentioned the substituents as mentioned above for the general formula (IIa). Practical examples and preferred examples of the (S)-2-amino-1-phenylethanol derivative of the general formula (XV) include (S)-forms corresponding to the compounds exemplified as the (R)-forms of the general formula (IIa). The (S)-2-amino-l-phenylethanol derivative of the general formula(XV) can be prepared by a variety of methods, for example, those analogous to the methods mentioned in the (R)-2-amino-1-phenylethanol derivative of the general formula (IIa). The object compound of the formula (XV) can by produced by a chemical synthesis, and can advantageously be produced with the use of an action of a microorganism or a preparation thereof. For instance, the (S)-form of the formula (XV) can readily and expediently be obtained by (F) permitting a specific microorganism or a preparation thereof to the compound of the general formula (VII) or a salt thereof to asymmetrically reduce and harvesting or recovering the product optionally active (S)-form or a salt thereof (hereinafter refereed to as asymmetric reduction method). The asymmetric reduction method (F) is illustrated hereinbelow. As the microorganism used in the method, any strain of microorganism which is capable of asymmetrically reducing the compound of the general (VII) to produce the corresponding optically active (S)-2-amino-1-phenylethanol derivative of the general formula (XV) can be employed. Such a microorganism includes, for instance, a strain of microorganism belonging to the genus Botryoascus , the genus Brettanomyces , the genus Candida , the genus Citeromyces , the genus Clavispora , the genus Debaryomyces , the genus Dipodascus , the genus Eremascus, the genus Galactomyces , the genus Geotrichum , the genus Issatchenkia, the genus Kluyveromyces , the genus Kondoa , the genus Lipomyces , the genus Malassezia , the genus Oosporidium , the genus Pachysolen , the genus Pichia , the genus Rhodosporidium , the genus Rhodotorula , the genus Saccharomyces , the genus Saccharomycodes , the genus Saccharomycopsis , the genus Schizoblastosporion , the genus Schizosaccharomyces , the genus Sporidiobolus , the genus Sporobolomyces , the genus Wickerhamiella, the genus Wingea , the genus Zygosaccharomyces , the genus Bacillus , the genus Comamonas , the genus Rhodobacter , the genus Enterococcus , the genus Lactoba cillus, the genus Pediococcus, the genus Leuconostoc, the genus Streptococcus and so on. As practical examples of the microorganism capable of acting on the aminoketone derivative of the general formula (VII) to produce the (S)-2-amino-1-phenylethanol derivative of the general formula (XV), there may be mentioned following strains of microorganisms: (99) the genus Botryoascus : Botryoascus synnaedendrus IFO 1604, etc., (100) the genus Brettanomyces : Brettanomyces anomalus IFO 0642, etc., (101) the genus Candida: Candida albicans IFO 1856, Candida beechii IFO 10229, Candida ergatensis IFO 10233, Candida fusiformata IFO 10225, Candida guilliermondii IFO 0566, Candida halonitratophila IFO 1595, Candida oregonensis IFO 1980, Candida peltata IFO 1853, Candida parapsilosis IFO 10305, Candida sorboxylosa IFO 1578, etc., (102) the genus Citeromyces : Citeromyces matritensis IFO 0954, etc., (103) the genus Clavispora : Clavispora lusitaniae IFO 1019, etc., (104) the genus Debaryomyces : Debaryomyces hansenii var. hansenii IFO 0083, etc., (105) the genus Dipodascus : Dipodascus ovetensis IFO 1201, etc., (106) the genus Eremascus : Eremascus fertilis IFO 0691, etc., (107) the genus Galactomyces : Galactomyces reessii IFO 1112, etc., (108) the genus Geotrichum : Geotrichum fermentans CBS 452.83, Geotrichum candidum IFO 4601, Geotrichum capitatum IFO 1197, Geotrichum klebahnii JCM 2171, etc., (109) the genus Issatchenkia : Issatchenkia scutulata var. scutulata IFO 10069, etc., (110) the genus Kluyveromyces : Kluyveromyces lactis IFO 1267, Kluyveromyces marxianus var. bulgaricus IAM 4829, etc., (111) the genus Kondoa : Kondoa malvinella IFO 1935, etc., (112) the genus Lipomyces : Lipomyces starkeyi IFO 1289, etc., (113) the genus Malassezia : Malassezia furfur IFO 0656, etc., (114) the genus Oosporidium : Oosporidium margaritiferum IFO 1208, etc., (115) the genus Pachysolen : Pachysolen tannophilus IFO 1007, etc., (116) the genus Pichia : Pichia farinosa IFO 1163, Pichia holstii IFO 0986, Pichia subpelliculosa IFO 0808, Pichia toletana IFO 0950, etc., (117) the genus Rhodosporidium : Rhodosporidium diobovatum IFO 0688, etc., (118) the genus Rhodotorula : Rhodotorula glutinis IFO 0389, Rhodotorula glutinis var. dairenensis IFO 0415, etc., (119) the genus Saccharomyces : Saccharomyces kluyveri IFO 1894, Saccharomyces paradoxus IFO 0259, etc., (120) the genus Saccharomycodes : Saccharomycodes ludwigii IFO 0798, etc., (121) the genus Saccharomycopsis : Saccharomycopsis capsularis IFO 0672, etc., (122) the genus Schizoblastosporion : Schizoblastosporion kobayasii IFO 1644, etc., (123) the genus Schizosaccharomyces : Schizosaccharomyces pombe IFO 0358, etc., (124) the genus Sporidiobolus : Sporidiobolus pararoseus JCM 5350, etc., (125) the genus Sporobolomyces : Sporobolomyces pararoseus IFO 0471, Sporobolomyces salmonicolor AHU 3982, etc., (126) the genus Wickerhamiella : Nickerhamiella domercquii IFO 1857, etc., (127) the genus Wingea : Wingea robertsii IFO 1277, etc., (128) the genus Zygosaccharomyces : Zygosaccharo myces bailii DSM 70492, Zygosaccharomyces fermentati IFO 0021, etc., (129) the genus Bacillus: Bacilus subtilis IFO 3037, etc., (130) the genus Comamonas : Comamonas terrigena IFO 13299, etc., (131) the genus Rhodobacter : Rhodobacter sphaeroides IFO 12203, etc., (132) the genus Enterococcus : Enterococcus faecalis NRIC 1142, etc., (133) the genus Lactobacillus : Lactobacillus lactis AHU 1059, etc., (134) the genus Pediococcus : Pediococcus acidilactici IFO 3076, etc., (135) the genus Leuconostoc : Leuconostoc mesenteroides subsp. dextranicum NRIC 1085, Leuconostoc mesenteroides AHU 1071, Leuconostoc oenos DSM 20252, etc., (136) the genus Streptococcus : Streptpcoccus uberis NRIC 1153, and so on. According to this method, any of wild strains, mutants and recombinant strains which can be obtained by a genetic engineering technique such as cell fusion or gene manipulation can suitable be employed so far as having the ability or capability mentioned above. The microorganisms identified hereinabove by IFO, AHU, DSM, JCM numbers are available from the above organizations. The microorganisms designated by IAM numbers are listed "IAM Catalogue of strains, 1st Ed. (1993) published by the Institute for Research Promotion of Applied Microbiology, and are available from General Center of Microbial Algae, Institute of Applied Microbiology, Tokyo University, Japan. The microorganism titled by CBS number is listed in "List of cultures FUNGI and YEAST, Ed. 32 (1990)" published by the CENTRAALBUREAU VOOR SCHIMMELCULTURES (CBS) and is available from the same organization. The microorganisms identified by NRIC numbers are described in "Catalogue of Microbial Strains, Ed. 2 (1992)" published by Laboratory of Cell Collection, Tokyo Agricultural University, Japan and are available from the same Laboratory. For the processes for the cultivation of the microorganism, asymmetric reduction and recovery of the product compound, those in the production of the (R)-2-amino-1-phenylethanol derivative of the general formula (IIa) may be referred to. The (S)-2-amino-1-phenylethanol derivative of the general formula (XV) may be converted to the (R)-2-amino-1-phenylethanol derivative of the formula (IIa) by, for example, subjecting the (S)-form to nucleophilic substitution reaction accompanied with a steric inversion. Such reaction can be conducted with the use of a nucleophilic reagent. The (S)-2-amino-1-phenylethanol derivative of the general formula (XV) can easily be converted to the (R)-2-amino-1-phenylethanol derivative shown by the general formula (IIa) by selecting an reagent, a catalyst and reaction conditions from a suitable range wherein the reaction is proceeded with steric inversion. For example, the reaction can be carried out in accordance with the following scheme: In the general formula (XV), R 1 , R 2 , R 3 , R 4 and R 5 have the same meanings as defined above. The conversion of the compound of the general formula (XV) to the compound of the general formula (IIa) can be carried out by, for example, the following method according to Mitsunobu reaction. The (R)-2-amino-1-phenylethanol derivative can be obtained by allowing an organic acid to react with the compound of the general formula (XV) in the presence of triarylphosphine (e.g. triphenylphosphine, etc.) and an azodicarboxylic acid ester such as ethyl azodicarbonate to form the sterically inverted corresponding organic acid ester, and hydrolyzing the resulting ester. The organic acid includes, for example, formic acid, acetic acid, trichloroacetic acid, trifluoroacetic acid, benzoic acid and the like. The formation of the organic acid ester may be conducted, for example, at a temperature of about -60°C to 60°C. The reaction may be carried out in an inert solvent such as an aromatic hydrocarbon (for example, benzene, toluene and so on) and an ether (e.g. tetrahydrofuran, etc.). The proportions of trialkylphosphine, organic acid and azodicarboxylic acid ester based on 1 mole of the compound of the general formula (XV) are respectively about 0.7 to 2.0 moles. The hydrolysis of the organic acid ester can be conducted by a conventional manner such as acid-hydrolysis or alkali-hydrolysis. Such method utilizing Mitsunobu reaction wherein an optically active alcohol is sterically inverted to the corresponding optically active alcohol may refer to methods or those analogous thereto described, for example, in Synthesis, 1 (1981); Tetrahedron Lett., 1619 (1973); and Bull. Chem. Soc. Jpn., 44 , 3427 (1971), and these descriptions can be incorporated to the present specification. For the conversion of the optically active alcohol to the corresponding enantiomer, following methods can also be applied: (a) the method comprising esterifying an optically active alcohol to a carboxylic acid ester such as trichloroacetic acid ester, and hydrolyzing the resultant carboxylic acid ester, in a water-ether solvent such as 75% H 2 O-dioxane, can also be applied (see Chem. Lett., 1976 , 893), and (b) the method which comprises (a) converting an optically active alcohol to a sulfonic acid ester such as p-toluenesulfonic acid ester, (b) allowing an organic acid salt such as tetraethylammonium acetate and sodium acetate (and acetic acid) to react with the resulting sulfonic acid ester to sterically invert to the corresponding organic acid ester, and (c) hydrolyzing the resultant organic acid ester (J. Am. Chem. Soc., 87 , 3682, (1965); and J. Chem. Soc., 1954 , 965). The obtained (R)-2-amino-1-phenylethanol derivative of the general formula (IIa) is, as described above, an specifically important intermediate for production of the (R,R)-1-phenyl-2-[[2-(phenyl)-1-alkylethyl]amino]ethanol derivative. Accordingly, the (S)-2-amino-1-phenylethanol derivative of the general formula (XV) used in the present invention is remarkably usable as an intermediate for the (R)-2-amino-1-phenylethanol derivative. The methods for conversion of the (S)-2-amino-1-phenylethanol derivative of the general formula (XV) to the (R)-2-amino-1-phenylethanol derivative of the general formula (IIa) can also be applied to the conversion of the corresponding (R)-form to the (S)-form. In the each method as described above, where a compound used as a raw material has a hydroxyl group or an amino group, the compound may be subjected to the reaction, if necessary, with being protected on the hydroxyl group or the amino group with a suitable protective group (e.g. the protective group for hydroxyl group, the protective group for amino group as referred to above, and the like). The following examples are intended to illustrate the invention in further detail and should by no means be construed as delimiting the scope of the invention. EXAMPLES The quantitative determination and optical purity determination of product 2-amino-1-phenylethanol derivative in the reaction mixture were carried out, unless specifically mentioned, by subjecting the reaction mixture to high performance liquid chromatography using an optical resolution column (column: Crownpack CR (trade name), Daicel Chemical Industries, Ltd.; mobile phase: perchloric acid buffer (pH 2.O); wavelength: 220 nm; flow rate: 1 ml/min.; column temperature: 40°C). Under the determination condition, for example, the retention time for (R)-2-amino-1-(3-chlorophenyl)ethanol is 16.8 minutes and (S)-2-amino-1-(3-chlorophenyl)ethanol is 18.5 minutes. Examples 1 to 100 [Production of (R)-2-amino-1-(3-chlorophenyl)ethanol] (not in accordance with the invention) Following media (1) and (2) were prepared for growing microbial strains. [Medium for preparation of cells (1) : for yeast and fungi] Glucose 2.0% by weight Yeast extract 0.3% by weight Malt extract 0.3% by weight Polypeptone 0.5% by weight Deionized water 96.9% by weight (pH 6.0) [Medium for preparation of cells (2): for bacterium and actinomyces] Glucose 2.0% by weight Yeast extract 0.5% by weight Meat extract 0.3% by weight Polypeptone 0.3% by weight Ammonium sulfate 0.2% by weight Potassium primary phosphate 0.1% by weight Deionized water 96.6% by weight (pH 7.0) A test tube of 21 mm in inner diameter was charged with 5 ml of the above mentioned medium respectively. After sterilization, the tube was inoculated with one of the following microbial strains. A yeast or fungus was inoculated to the Medium (1) and a bacterium or actinomyces was inoculated to the Medium (2) respectively, and the inoculated tube was incubated under shaking at 30°C for 48 hours. After the incubation, the wet viable cells were isolated by centrifuging. [Yeasts] Example 1: Hansenula anomala IFO 0707 Example 2: Geotrichum candidum IFO 4601 Example 3: Geotrichum candidum IFO 4598 Example 4: Candida albicans IFO 1594 Example 5: Candida albicans IFO 1856 Example 6: Candida parapsilosis IFO 1022 Example 7: Candida gropengiesseri IFO 0659 Example 8: Candida aaseri IFO 10404 Example 9: Candida beechii IFO 10229 Example 10: Candida atmospherica IFO 1969 Example 11: Candida natalensis IFO 1981 Example 12: Candida paludigena IFO 10330 Example 13: Candida sake IFO 1149 Example 14: Candida pintolopesii var. pintolopesii IFO 0729 Example 15: Cryptococcus neoformans IAM 4788 Example 16: Rhodosporidium spaerocarpum IFO 1438 Example 17: Rhodosporidium diobovatum IFO 0688 Example 18: Rhodotorula rubra IFO 0406 Example 19: Rhodotorula rubra AHU 3948 Example 20: Rhodotorula glutinis var. dairenensis IFO 0415 Example 21: Sporobolomyces roseus IFO 1040 Example 22: Kluyveromyces marxianus var. bulgari cus IAM 4829 Example 23: Kluyveromyces lactis IFO 1267 Example 24: Issatchenkia scutulata var. scutulata IFO 10069 Example 25: Issatchenkia scutulata var. scutulata IFO 10070 Example 26: Pichia thermotolerans IFO 10024 Example 27: Pichia farinosa IFO 1163 Example 28: Botryoascus synnaedendrus IFO 1604 Example 29: Debaryomyces hansenii IFO 0083 Example 30: Lipomyces starkeyi IFO 1289 Example 31: Metschnikowia bicuspidata IFO 1408 Example 32: Saccharomycodes ludwigii IFO 0798 Example 33: Schizoblastosporion kobayashii IFO 1644 Example 34: Stepahnoascus ciferrii IFO 1854 Example 35: Sterigmatomyces halophilus IFO 1488 Example 36: Zygosaccharomyces rouxii IFO 0510 Example 37: Zygosaccharomyces rouxii IAM 4114 Example 38: Zygosaccharomyces fermentati IFO 0021 Example 39: Sporidiobolus salmonicolor IFO 1845 Example 40: Sporidiobolus pararoseus IFO 1107 Example 41: Malassezia furfur IFO 0656 Example 42: Torulaspora delbrueckii IFO 0955 Example 43: Saccharomycopsis capsularis IFO 0672 Example 44: Leucosporidium scottii IFO 1923 Example 45: Leucosporidium scottii IFO 1924 [Fungi] Example 46: Agrocybe cylindracea IFO 30299 Example 47: Trichoderma viride IFO 5720 Example 48: Alternaria kikuchiana IFO 5778 Example 49: Hamigera avellanea IFO 7721 Example 50: Moniliella acetoabutans IFO 9481 Example 51: Pholiota nameko IFO 6141 Example 52: Podospola cardonaria IFO 30294 Example 53: Aegerita candida IFO 6988 [Bacteria and Actinomyces] Example 54: Corynebacterium aquaticum IFO 12154 Example 55: Corynebacterium mediolanum JCM 3346 Example 56: Gluconobacter asaii IFO 3265 Example 57: Gluconobacter oxydans IFO 3255 Example 58: Gluconobacter oxydans IFO 3130 Example 59: Gluconobacter oxydans IFO 3289 Example 60: Gluconobacter frateurii IFO 3271 Example 61: Promicromonospora citrea IFO 12397 Example 62: Pseudomonas aeruginosa IFO 3899 Example 63: Pseudomonas riboflavina IFO 13584 Example 64: Pseudomonas fluorescens IFO 3925 Example 65: Pseudomonas putida IFO 12996 Example 66: Pseudomonas syncyanea IFO 3757 Example 67: Pseudomonas diminuta IFO 12697 Example 68: Pseudomonas chlororaphis IFO 3522 Example 69: Pseudomonas fragi IFO 3458 Example 70: Pseudomonas sp. ATCC 14676 Example 71: Bordetella bronchiseptica IFO 13691 Example 72: Acetobacter sp. IFO 3248 Example 73: Acetobacter sp. IFO 3297 Example 74: Acetobacter pasteurianus ATCC 10245 Example 75: Acetobacter pasteurianus IFO 3259 Example 76: Acetobacter pasteurianus IFO 3277 Example 77: Bacillus subtilis IFO 3013 Example 78: Bacillus subtilis IFO 3009 Example 79: Bacillus cereus AHU 1355 Example 80: Bacillus cereus AHU 1707 Example 81: Bacillus cereus IFO 3001 Example 82: Bacillus coagulans IAM 1115 Example 83: Bacillus brevis IFO 3331 Example 84: Bacillus sphaericus IFO 3525 Example 85: Agrobacterium radiobacter IFO 12664 Example 86: Arthrobacter ureafaciens IFO 12140 Example 87: Amauroascus reticulatus IFO 9196 Example 88: Brevibacterium linens IFO 12141 Example 89: Micrococcus roseus IFO 3764 Example 90: Aureobacterium testaceum IFO 12675 Example 91: Azotobacter vinelandii IFO 13581 Example 92: Xanthomonas campestris pv oryzae IAM 1657 Example 93: Klebsiella pneumoniae IFO 3317 Example 94: Comamonas testosteroni IFO 12048 Example 95: Comamonas testosteroni IAM 1048 Example 96: Mycobacterium diernhoferi IFO 3707 Example 97: Terrabacter tumescens IFO 12960 Example 98: Streptomyces cinereoruber HUT 6142 Example 99: Rhodococcus amidophilis IFO 0144 Example 100: Rhodococcus equi JCM 1313 A test tube of 21 mm  in inner diameter was charged with 1 ml of 0.1M potassium phosphate buffer (pH 7.0), and the wet viable cells obtained above was suspended therein. A racemic 2-amino-1-(3-chlorophenyl)ethanol (5 µl) was added to the suspension and reaction was conducted on a reciprocating shaker at 30°C for 48 hours. After completion of the reaction, cells were removed from the reaction mixture by centrifugation, and the supernatant was subjected to high performance liquid chromatography to determine the amount, absolute configuration and optical purity of the obtained optically active 2-amino-1-(3-chlorophenyl)ethanol. The results are set forth in Tables 1 to 5. In the following Tables, the term "amount" means the amount (mg/ml) of the optical active 2-amino-1-(3-chlorophenyl)ethanol contained in the reaction mixture. Example No. Absolute configuration Optical purity (% e e) Amount (mg/ml) 1 R 100 0.01 2 R 61 0.2 3 R 68 0.08 4 R 66 1.1 5 R 100 0.02 6 R 57 0.6 7 R 100 0.9 8 R 82 0.4 9 R 69 0.8 10 R 75 1.3 11 R 57 0.1 12 R 77 0.7 13 R 68 1.5 14 R 63 0.1 15 R 100 0.03 16 R 100 1.0 17 R 55 1.0 18 R 100 0.01 19 R 61 0.1 20 R 82 0.5 Example No. Absolute configuration Optical purity (% e e) Amount (mg/ml) 21 R 77 1.3 22 R 100 0.01 23 R 56 1.1 24 R 78 1.1 25 R 70 1.4 26 R 52 1.2 27 R 99 0.9 28 R 100 1.4 29 R 93 0.7 30 R 100 0.02 31 R 57 1.1 32 R 100 0.02 33 R 77 0.1 34 R 100 0.01 35 R 100 1.0 36 R 95 0.4 37 R 78 0.3 38 R 67 0.04 39 R 100 0.9 40 R 100 1.2 Example No. Absolute configuration Optical purity (% e e) Amount (mg/ml) 41 R 100 0.2 42 R 100 0.03 43 R 100 0.6 44 R 63 1.0 45 R 81 0.1 46 R 48 0.8 47 R 14 0.2 48 R 39 0.2 49 R 11 0.8 50 R 31 0.6 51 R 14 0.4 52 R 14 0.8 53 R 29 2.2 54 R 100 0.1 55 R 14 1.5 56 R 100 2.2 57 R 90 1.3 58 R 79 1.6 59 R 30 3.8 60 R 62 2.5 Example No. Absolute configuration Optical purity (% e e) Amount (mg/ml) 61 R 100 0.4 62 R 72 1.8 63 R 40 1.9 64 R 35 2.6 65 R 26 1.6 66 R 20 2.6 67 R 19 2.3 68 R 12 2.2 69 R 12 3.5 70 R 14 2.1 71 R 100 0.3 72 R 100 1.8 73 R 100 1.6 74 R 24 3.2 75 R 75 2.2 76 R 15 4.2 77 R 100 0.9 78 R 45 1.3 79 R 94 1.6 80 R 30 2.3 Example No. Absolute configuration Optical purity (% e e) Amount (mg/ml) 81 R 21 2.2 82 R 76 1.3 83 R 33 1.7 84 R 13 1.9 85 R 90 1.5 86 R 20 1.4 87 R 75 0.8 88 R 74 3.5 89 R 63 2.2 90 R 43 0.7 91 R 37 1.6 92 R 20 3.3 93 R 13 5.1 94 R 100 1.8 95 R 21 2.2 96 R 100 0.4 97 R 16 1.3 98 R 13 1.4 99 R 12 2.7 100 R 14 3.9 Examples 101 to 111 [Production of (R)-2-amino-1-phenylethanol] A medium for preparation of cells (3) having the following composition was prepared. For yeasts and fungi, the media for preparation of cells (1) used in Examples 1 to 100 was employed. [Medium for preparation of cells (3): for bacteria] Glucose 2.0% by weight Yeast extract 0.5% by weight Meat extract 0.3% by weight Polypeptone 0.3% by weight Ammonium sulfate 0.2% by weight Potassium primary phosphate 0.1% by weight Magnesium sulfate 0.05% by weight Deionized water 96.55% by weight (pH 7.0) A test tube of inner diameter of 21 mm was charged with 5 ml of the media respectively. After sterilization, the tube was inoculated with one of following microorganism. The medium (1) was used for a yeast and fungus and the medium (3) was employed for a bacterium respectively. The inoculated tube was incubated under shaking at 30°C for 48 hours. Example 101: Candida maltosa IFO 1977 Example 102: Candida maltosa IFO 1978 Example 103: Lodderomyces elongisporus IFO 1676 Example 104: Catenuloplanes japonicus IFO 14176 Example 105: Pilimelia terevasa IFO 14556 Example 106: Saccharothrix australiensis IFO 14444 Example 107: Seratia marcescens IFO 3735 Example 108: Enterococcus faecalis IFO 12964 Example 109: Lactobacillus casei subsp. casei NRIC 1042 Example 110: Pediococcus acidilactici NRIC 1089 Example 111: Lactococcus lactis subsp. lactis AHU 1089 Cells were collected by centrifuging and a test tube of inner diameter of 21 mm was charged with 1 ml of 0.1M phosphate buffer (pH 7.0) containing 0.5% by weight of aminomethyl=phenyl=ketone hydrochloride and 5% by weight of glucose. To the charged tube, were suspended the cells and the reaction was carried out on a reciproshaker at 30°C for 48 hours. After completion of the reaction, the cells were removed off by centrifuging, and the supernatant was submitted to high performance liquid chromatography to determine the amount, the absolute configuration and the optical purity of the product (R)-2-amino-1-phenylethanol. The results are shown in Table 6. In the Table, the term "amount" refers to the amount of the product (R)-2-amino-1-phenylethanol in the reaction mixture. Example No. Absolute configuration Optical purity (% e e) Amount (mg/ml) 101 R 68 2.4 102 R 89 3.1 103 R 100 3.7 104 R 100 1.6 105 R 100 1.6 106 R 100 1.7 107 R 100 1.6 108 R 76 1.8 109 R 100 1.5 110 R 65 2.2 111 R 84 2.1 Examples 112 to 115 [production of (R)-2-amino-1-(3-chlorophenyl)ethanol] The procedures of cultivation, reaction and determination in Example 101 were repeated except for employing the following strains of microorganisms and using aminomethyl=3-chlorophenyl=ketone hydrochloride instead of aminomethyl=phenyl=ketone hydrochloride. The proportion, the absolute configuration and the optical purity of the product (R)-2-amino-1-(3-chlorophenyl)ethanol were determined. The results were set forth in Table 7. In the Table, the term "amount" means the amount of (R)-2-amino-1-(3-chlorophenyl)ethanol in the reaction mixture (mg/ml). Example 112: Lodderomyces elongisporus IFO 1676 Example 113: Candida maltosa IFO 1978 Example 114: Candida maltosa IFO 1977 Example 115: Pilimelia terevasa IFO 14556 Example No. Absolute configuration Optical purity (% e e) Amount (mg/ml) 112 R 100 2.3 113 R 100 2.3 114 R 100 1.9 115 R 95 1.3 Examples 116 to 118 [production of (R)-2-amino-1-(3,4-dihydroxyphenyl)ethanol] The cultivation, reaction and analysis were conducted in the same manner as in Example 101, except that the following strains of microorganisms were respectively used and aminomethyl=3,4-dihydroxyphenyl=ketone hydrochloride was employed instead of aminomethyl=phenyl=ketone hydrochloride to determine the proportion, the absolute configuration and the optical purity of the product (R)-2-amino-1-(3,4-dihydroxyphenyl)ethanol. The results are shown in Table 8. In the Table 8, the term "amount" means the amount of the (R)-2-amino-1-(3,4-dihydroxyphenyl)ethanol in the reaction mixture (mg/ml). Example 116: Lodderomyces elongisporus IFO 1676 Example 117: Candida maltosa IFO 1977 Example 118: Candida maltosa IFO 1978 Example No. Absolute configuration Optical purity (% e e) Amount (mg/ml) 116 R 100 1.9 117 R 100 1.7 118 R 100 2.1 Example 119 [production of (R)-2-amino-1-(3-chlorophenyl)ethanol] A 2.6-liter jar fermenter was charged with 1.5 liter of GY medium containing 2.4% by weight of glucose, 1.8% by weight of yeast extract, 0.2% by weight of ammonium sulfate, 0.1% by weight of potassium primary phosphate, 15 ppm of ferrous sulfate heptahydrate, 15 ppm of zinc sulfate heptahydrate. After sterilized by an autoclave, the jar fermenter was inoculated with Candida maltosa IFO 1978. The inoculated jar fermenter was incubated at pH 6.0, at 30°C, under aeration at 1 vvm, with stirring at a rate of 400 rpm for 24 hours. After completion of incubation, the cells were collected and suspended to 1 liter of 0.1M phosphate buffer (pH 6.5) charged in a 2.6-liter jar fermenter. To the mixture, was added 20 g of aminomethyl=3-chlorophenyl=ketone and 50 g of glucose, and the reaction was carried out at 30°C, without aeration, and stirring at a rate of 200 rpm for 48 hours. In the course of the reaction, the pH of the reaction mixture was adjusted at 6.5 with the use of an 20% aqueous solution of sodium hydroxide. On the way of the reaction, according to the analysis of the reaction mixture, (R)-2-amino-1-(3-chlprophenyl)ethanol was produced in a concentration of 13.2 g per liter. After completion of the reaction, the reaction mixture was acidified to pH 2 or less by using a concentrated hydrochloric acid, and the cells were removed off by centrifugation. The obtained supernatant was subjected to dehydration-concentration with using a vacuum rotary evaporator at a bath-temperature of 50°C. The resultant concentrated was adjusted to pH 9.0 by adding a 20% aqueous solution of sodium hydroxide and was added with 50 g of sodium chloride and extracted three times with 300 ml of methylene chloride. The methylene chloride extract was dried over anhydrous sodium sulfate and the solvent was removed off under reduced pressure to obtain 9.8 g of an oily substance. The optical purity of the obtained (R)-2-amino-1-(3-chlorophenyl)ethanol was 100% e e by the analysis with high performance liquid chromatography using an optical resolution column [column: product of Daicel Chemical Industries, Ltd., Crownpack CR (+) (trade name)] In the following Examples 120 to 172, the determination of optical purity of the obtained (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative or a salt thereof was carried out with high performance liquid chromatography using an optical resoluting column [column: manufactured by Daicel Chemical Industries, Ltd., Chiralpack AD (trade name); solvent: n-hexane/2-propanol/diethylamine = 90/10/0.1; flow rate: 0.5 ml/minute; temperature: 25°C; wavelength: 230 nm]. Example 120 [production of (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino] ethanol] To 5.83 g of methyl=3,4-dimethoxyphenylmethyl= ketone, 5.15 g of (R)-2-amino-1-(3-chlorophenyl)ethanol and 50 mg of platinum oxide, were added 15 ml of isopropyl alcohol, 30 ml of diisopropyl ether and 2 drops of acetic acid. The mixture was subjected to reduction at room temperature and at 1 atm under hydrogen atmosphere for 24 hours. After completion of the reaction, platinum oxide was removed off by filtration and the solvent was distilled off under reduced pressure to obtain 8.43 g of white oil of (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol (yield: 80.3%). The optical purity of the obtained (R,R)-isomer was 80%. Examples 121 to 128 [production of (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol (R, R)-1-(3-Chlorophenyl) -2- [[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol was obtained in the same manner as in Example 120 except for using 0.344 g of methyl=3,4-dimethoxyphenylmethyl=ketone, 0.304 g of (R)-2-amino-1-(3-chlorophenyl)ethanol, 50 mg of platinum oxide and 10 ml of a solvent. The solvent, the yield and the optical purity of the (R,R)-isomer are set forth in Table 9. In the following Tables 9 to 13, the term "OMe" means a methoxy group, the term "Me" refers to a methyl group, the term "NHAc" means an amino group substituted with an acetyl group, and the term "PTsOH" refers to p-toluenesulfonic acid. The term "optical purity" refers to the optical purity of the (R,R)-isomer. Example No. Solvent used Yield (%) Optical purity (%) 121 Methanol 73 75 122 Ethanol 74 75 123 Isopropyl alcohol 70 74 124 Toluene-methanol 78 72 125 Toluene 58 73 126 Tetrahydrofuran 63 74 127 Acetonitrile 50 68 128 Ethyl acetate 55 70 Examples 129 to 141 [production of (R,R)-1-phenyl-2-[[2-(phenyl)-1-alkylethyl]amino]ethanol derivatives] The procedures of Example 120 were repeated to obtain an (R, R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative except for using platinum oxide as the catalyst for catalytic reduction, isopropyl alcohol-diisopropyl ether (1:2) as the solvent, acetic acid as the acid, and the compounds shown in Table 10 as the raw materials. The raw materials, the yields, the optical purity of the (R,R)-isomer were set forth in Table 10. Example 142 [production of (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl] amino]ethanol To 40 ml of benzene solution of (R)-2-amino-1-(3-chlorophenyl)ethanol (0.304 g), was added 0.344 g of methyl=3,4-dimethoxyphenylmethyl=ketone. The mixture was refluxed in an apparatus equipped with a water-trap for one hour and the water produced was removed from the reaction system. After cooling the reaction mixture, the solvent was distilled off under reduced pressure, and the residue was dissolved into 10 ml of methanol. To the mixture was added platinum oxide, and the reducing reaction was conducted at room temperature at 1 atm pressure under hydrogen atmosphere for 24 hours. After removing off platinum oxide by filtration, the solvent was distilled off under reduced pressure to give 0.501 g of white oil of (R,R)-1-(3-chlorophenyl)-2-[[2-(3, 4-dimethoxyphenyl)-1-methylethyl]amino]ethanol (yield 81.0%). The optical purity of the (R,R)-isomer was 80%. Examples 143 to 150 [production of (R,R)-1-phenyl-2-[[2-(phenyl)-1-alkylethyl]aminolethanol derivatives] (R,R)-1-Phenyl-2-(2-phenyl-1-alkylethyl)amino] ethanol derivatives were obtained in the same manner as in Example 142 by using isopropyl alcohol-diisopropyl ether (1:2) as the solvent, and the raw materials and the catalysts for catalytic reduction are set forth in Table 11. The raw materials, the catalysts for catalytic reduction, yields and the optical purity of the (R,R)-isomers are shown in Table 11. Example 151 [production of (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl] amino]ethanol] To 12.36 g of (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol having an optical purity of 89%, was added toluene solution of hydrogen chloride to obtain a hydrochloride of the titled compound, and the solvent was distilled off under reduced pressure to give an oil. The oil was subjected to recrystallization by using a mixture of isopropyl alcohol and diisopropyl ether to give 7.57 g of white powder. A mixture of a 10% sodium hydroxide/ethyl acetate was added to the powder and the solvent was distilled off to give (R,R)-1-(3-chlorophenyl)-2-[(2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol (7.58 g, optical purity 98%). Example 152 [production of (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl] amino]ethanol] To 1 ml of isopropyl alcohol was added 0.103 g of (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol having an optical purity of 64% to be dissolved, and 0.057 g of (R)-(-)-2-(2,4,6-trimethylphenyl)propionic acid and 2 ml of diisopropyl ether were added to the solution successively to give 0.102 g of white powder. To the powder was added 10% sodium hydroxide/ethyl acetate, and the solvent was distilled off to afford 0.065 g of (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl] amino]ethanol having an optical purity of 92%. Example 153 [production of (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl] amino]ethanol] To 1 ml of isopropyl alcohol was added 0.103 g of (R, R) -1- (3-chlorophenyl) -2- [[2-(3,4-dimethoxyphenyl) -1-methylethyl] amino]ethanol having an optical purity of 64% to be dissolved and 0.056 g of (S)-2-(2,5-dimethylphenyl)propionic acid and 4 ml of diisopropyl ether were added to the solution successively to give 0.046 g of white powder. A mixture of 10% sodium hydroxide/ethyl acetate was added to the white powder and the solvent was distilled off to yield 0.030 g of (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol having an optical purity of 99.4%. Examples 154 to 168 [production of (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivatives] The procedures of Example 153 were repeated except that isopropyl alcohol-diisopropyl ether (1:2) was used as the solvent and the raw materials and the acids shown in Table 12 were employed to give (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivatives. The optical purity of the raw materials was 65%. The optical purity of the (R,R)-isomer thus obtained was set forth in Table 12. Example 169 [production of (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl] amino]ethanol] To (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol (1.05 g) having an optical purity of 65% was added a toluene solution of hydrogen chloride to give a hydrochloride, and the solvent was distilled off under reduced pressure to afford an oily substance. Triethylamine (0.15 g) was added to the obtained oily substance, and the mixture was subjected to recrystallization with the use of a mixture of isopropyl alcohol and diisopropyl ether to give 0.80 g of white powder. To the white powder was added 10% sodium hydroxide/ethyl acetate, and the solvent was distilled off to afford 0.70 g of (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl]amino]ethanol (optical purity 90%). Examples 170 and 171 [production of (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivatives] (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino] ethanol derivatives were obtained in the same manner as in Example 169 by using isopropyl alcohol-diisopropyl ether (1:2) as the solvent, and the acids and bases shown in Table 13 as the acids and bases. The raw materials, the acids, the bases and the optical purity of the product (R,R)-isomer are set forth in Table 13. The optical purity of the raw material was 65%. In the Table, the term "HCl" means hydrochloric acid. Example No. R 1 R 2 R 3 R 4 R 5 Z R 6 R 7 R 8 R 9 R 10 R 11 Acid Base Optical purity (%) 170 H H H H H H H OMe OMe H H Me HCI Triethylamine 88 171 H Cl H H H H H OMe OMe H H Me Acetic acid Triethylamine 85 Example 172 [production of (R,R)-1-(3-chlorophenyl) -2- [[2-(3,4-dimethoxyphenyl) -1-methylethyl] amino]ethanol] To a mixture of 5.83 g of methyl=3,4-dimethoxyphenylmethyl=ketone, 5.15 g of (R)-2-amino-1-(3-chlorophenyl)ethanol and 50 mg of platinum oxide were added 15 ml of isopropyl alcohol and 30 ml of diisopropyl ether, and the reducing reaction was carried out at room temperature, at 1 atm under hydrogen atmosphere for 24 hours. After removing off platinum oxide by filtration, the solvent was distilled off under reduced pressure to give 6.51 g of white oil of (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl] amino]ethanol (yield 62%). The optical purity of the (R,R)-isomer was 65%. Examples 173 to 222 [production of (S)-2-amino-1 (3-chlorophenyl)ethanol] (not in accordance with the invention) (S)-2-Amino-1-(3-chlorophenyl)ethanol was produced in the similar manner as in Examples 1 to 100, except that the following strains of microorganisms were used respectively. The results of determination of the amount, the absolute configuration and the optical purity of the obtained (S)-2-amino-1-phenylethanol are shown in Tables 14 to 16. In the Tables 14 to 16, the term "amount" means the amount (mg/ml) of (S)-2-amino-1-(3-chlorophenyl)ethanol in the reaction mixture. [Yeasts] Example 173: Saccharomyces cerevisiae IFO 0718 Example 174: Saccharomyces cerevisiae IFO 0735 Example 175: Saccharomyces cerevisiae IFO 0206 Example 176: Pichia fabianii IFO 1254 Example 177: Schizosaccharomyces pombe IAM 4890 Example 178: Candida guilliermondii IFO 0566 Example 179: Candida melibiosica IFO 10238 Example 180: Hansenula polymorpha DSM 70277 Example 181: Yarrowia lipolytica IFO 0746 Example 182: Geotrichum capitatum IFO 0743 Example 183: Geotrichum capitatum IFO 1197 [Fungi] Example 184: Aspergillus niger IFO 4415 Example 185: Aspergillus niger AHU 7115 Example 186: Aspergillus ficuum IFO 4318 Example 187: Aspergillus cavdidus IFO 4389 Example 188: Aspergillus oryzae IFO 4390 Example 189: Aspergillus oryzae var. brunneus JCM 2240 Example 190: Aspergillus tamarii IAM 2138 Example 191: Penicillium chrysogenum IAM 7142 Example 192: Corynespora cassiicola IFO 6724 Example 193: Fusarium solani IFO 5232 Example 194: Gelasinospora cerealis IFO 6759 Example 195: Helminthosporium sigmoideum var. irreavl IFO 5273 Example 196: Mortierelia isabellina IFO 6336 Example 197: Mortierelia ramanniana var. ramanni ana IFO 7825 Example 198: Neosartorya fischeri var. spinosa IFO 5955 Example 199: Phytophthora capsici IFO 8386 Example 200: Talaromyces flavus var. flavus IFO 7231 Example 201: Scolecobasidium terreum IFO 8854 [Bacteria & Actinomyces] Example 202: Micrococcus luteus IAM 12009 Example 203: Micrococcus luteus IAM 12144 Example 204: Micrococcus luteus IAM 1157 Example 205: Micrococcus luteus IFO 3333 Example 206: Brevibacterium iodinum IFO 3558 Example 207: Corynebacterium sepedonicum IFO 3306 Example 208: Xanthomonas sp. IFO 12997 Example 209: Actinomaqura cremea subsp. cremea IFO 14182 Example 210: Enterobacter aerogenes IFO 12010 Example 211: Pseudomonas aeruginosa IFO 3445 Example 212: Hafnia alvei IFO 3731 Example 213: Actinoplanes lobatus IFO 12513 Example 214: Escherichia coli IAM 1239 Example 215: Bacillus licheniformis BGSC 5A18 Example 216: Listonella anguillarum IFO 12710 Example 217: Nosardioides flavus IFO 14396 Example 218: Amycolata autotrophica IFO 12743 Example 219: Rhodococcus luteus JCM 6162 Example 220: Rhodococcus erythropolis JCM 6821 Example 221: Rhodococcus erythropolis JCM 6827 Example 222: Rhodococcus globerrulus IFO 14531 Example No. Absolute configuration Optical purity (% e e) Amount (mg/ml) 173 S 59 0.3 174 S 100 0.1 175 S 54 0.5 176 S 69 0.9 177 S 70 0.3 178 S 67 0.05 179 S 78 0.1 180 S 66 0.4 181 S 100 0.04 182 S 100 0.2 183 S 73 0.5 184 S 21 0.8 185 S 64 0.3 186 S 57 0.6 187 S 19 0.8 188 S 22 0.7 189 S 24 1.0 190 S 57 0.5 191 S 17 0.6 192 S 14 0.5 Example No. Absolute configuration Optical purity (% e e) Amount (mg/ml) 193 S 52 0.7 194 S 38 0.4 195 S 72 0.4 196 S 31 0.8 197 S 61 0.9 198 S 10 1.0 199 S 24 0.8 200 S 13 0.2 201 S 20 0.8 202 S 97 1.0 203 S 34 5.5 204 S 31 5.2 205 S 55 1.0 206 S 75 1.4 207 S 64 1.8 208 S 53 1.6 209 S 47 1.1 210 S 41 1.1 211 S 12 6.2 212 S 13 3.2 Example No. Absolute configuration Optical purity (% e e) Amount (mg/ml) 213 S 13 0.9 214 S 13 2.2 215 S 12 2.9 216 S 12 6.2 217 S 11 1.4 218 S 10 1.4 219 S 28 2.5 220 S 47 1.8 221 S 40 2.2 222 S 48 1.8 Examples 223 to 282 [production of (S)-2-amino-1-phenylethanol A test tube of 21 mm in inner diameter was charged with 5 ml of YM medium containing 2.0% by weight of glucose, 0.3% by weight of yeast extract, 0.3% by weight of malt extract and 0.5% by weight of polypeptone (pH 6.0) for yeast or fungus, or 5 ml of PM medium containing 2.0% by weight of glucose, 0.5% by weight of yeast extract, 0.3% by weight of meat extract, 0.3% by weight of polypeptone, 0.2% by weight of ammonium sulfate, 0.1% by weight of potassium phosphate and 0.05% by weight of magnesium sulfate (pH 7.0). After sterilization, the tube was respectively inoculated with one of the following strains of microorganisms. The inoculated tube was incubated under shaking at 30°C for 48 hours. [Yeasts and fungi] Example 223: Botryoascus synnaedendrus IFO 1604 Example 224: Brettanomyces anomalus IFO 0642 Example 225: Candida albicans IFO 1856 Example 226: Candida beechii IFO 10229 Example 227: Candida ergatensis IFO 10233 Example 228: Candida fusiformata IFO 10225 Example 229: Candida guilliermondii IFO 0566 Example 230: Candida halonitratophila IFO 1595 Example 231: Candida oregonensis IFO 1980 Example 232: Candida peltata IFO 1853 Example 233: Candida parapsilosis IFO 10305 Example 234: Candida sorboxylosa IFO 1578 Example 235: Citeromyces matritensis IFO 0954 Example 236: Clavispora lusitaniae IFO 1019 Example 237: Debaryomyces hansenii var. hansenii IFO 0083 Example 238: Dipodascus ovetensis IFO 1201 Example 239: Eremascus fertilis IFO 0691 Example 240: Galactomyces reessii IFO 1112 Example 241: Geotrichum fermentans CBS 452.83 Example 242: Geotrichum candidum IFO 4601 Example 243: Geotrichum capitatum IFO 1197 Example 244: Geotrichum klebahnii JCM 2171 Example 245: Issatchenkia scutulata var. scutulata IFO 10069 Example 246: Kluyveromyces lactis IFO 1267 Example 247: Kluyveromyces marxianus var. bulgaricus IAM 4829 Example 248: Kondoa malvinella IFO 1935 Example 249: Lipomyces starkeyi IFO 1289 Example 250: Malassezia furfur IFO 0656 Example 251: Oosporidium margaritiferum IFO 1208 Example 252: Pachysolen tannophilus IFO 1007 Example 253: Pichia farinosa IFO 1163 Example 254: Pichia holstii IFO 0986 Example 255: Pichia subpelliculosa IFO 0808 Example 256: Pichia toletana IFO 0950 Example 257: Rhodosporidium diobovatum IFO 0688 Example 258: Rhodotorula glutinis IFO 0389 Example 259: Rhodotorula glutinis var. dairenensis IFO 0415 Example 260: Saccharomyces kluyveri IFO 1894 Example 261: Saccharomyces paradoxus IFO 0259 Example 262: Saccharomycodes ludwigii IFO 0798 Example 263: Saccharomycopsis capsularis IFO 0672 Example 264: Schizoblastosporion kobayasii IFO 1644 Example 265: Schizosaccharomyces pombe IFO 0358 Example 266: Sporidiobolus pararoseus JCM 5350 Example 267: Sporobolomyces pararoseus IFO 0471 Example 268: Sporobolomyces salmonicolor AHU 3982 Example 269: Wickerhamiella domercquii IFO 1857 Example 270: Wingea robertsii IFO 1277 Example 271: Zygosaccharomyces bailii DSM 70492 Example 272: Zygosaccharomyces fermentati IFO 0021 [Bacteria] Example 273: Bacilus subtilis IFO 3037 Example 274: Comamonas terrigena IFO 13299 Example 275: Rhodobacter sphaeroides IFO 12203 Example 276: Enterococcus faecalis NRIC 1142 Example 277: Lactobacillus lactis AHU 1059 Example 278: Pediococcus acidilactici IFO 3076 Example 279: Leuconostoc mesenteroides subsp. dextranicum NRIC 1085 Example 280: Leuconostoc mesenteroides AHU 1071 Example 281: Leuconostoc oenos DSM 20252 Example 282: Streptpcoccus uberis NRIC 1153 The cells were isolated by centrifuging and suspended in 1 ml of 0.1M phosphate buffer (pH 7.0) containing 0.5% by weight of aminomethyl=phenyl=ketone hydrochloride and 5% by weight of glucose. A test tube of 21 mm inner diameter was charged with the suspension and reaction was conducted on a reciprocating shaker at 30°C for 48 hours. After completion of the reaction, the cells were removed from the reaction suspension by centrifuging. The supernatant was subjected to the analysis with high performance liquid chromatography to determine the amount, the absolute configuration and the optical purity of the product (S)-2-amino-1-phenylethanol. The results are set forth in Tables 17 to 19. In the Tables 17 to 19, the term "amount" refers to the amount of the (S)-2-amino-1-phenylethanol in the reaction mixture (mg/ml) and the term "optical purity" means the optical purity of the (S)-form. Example No. Absolute configuration Optical purity (% e e) Amount (mg/ml) 223 S 100 1.6 224 S 100 1.9 225 S 100 1.9 226 S 100 1.6 227 S 91 2.0 228 S 95 1.8 229 S 92 1.7 230 S 100 1.8 231 S 100 1.6 232 S 100 1.8 233 S 100 1.7 234 S 100 1.8 235 S 100 2.6 236 S 74 1.7 237 S 100 1.7 238 S 65 1.9 239 S 66 1.9 240 S 88 2.8 241 S 84 2.0 242 S 100 1.7 Example No. Absolute configuration Optical purity (% e e) Amount (mg/ml) 243 S 90 2.1 244 S 78 3.2 245 S 100 1.7 246 S 100 2.4 247 S 100 1.7 248 S 100 1.9 249 S 71 2.0 250 S 100 1.7 251 S 100 2.5 252 S 74 1.8 253 S 100 1.7 254 S 100 2.2 255 S 100 1.7 256 S 100 1.6 257 S 100 1.9 258 S 76 1.9 259 S 90 1.9 260 S 100 3.4 261 S 100 1.9 262 S 100 1.5 Example No. Absolute configuration Optical purity (% e e) Amount (mg/ml) 263 S 100 1.7 264 S 69 1.7 265 S 100 1.6 266 S 100 1.8 267 S 72 1.6 268 S 100 2.4 269 S 100 1.7 270 S 100 3.1 271 S 100 2.0 272 S 85 1.9 273 S 96 1.6 274 S 94 2.0 275 S 100 1.7 276 S 63 2.9 277 S 100 2.9 278 S 100 1.5 279 S 74 2.4 280 S 100 1.6 281 S 100 2.3 282 S 81 2.7 In the following Examples 283 to 303, the chemical purity and the optical purity of the product compound were determined with high performance liquid chromatography using the following columns, and unless specifically defined, the term "%" refers to % by weight. chemical purity: column; manufactured by G. L. Science, Ltd., Innertosyl ODS-2 (trade name) optical purity: column; manufactured by Daicel Chemical Industries, Ltd., Crownpack CR (trade name) Example 283 [production of (R,R)-1-(3-chlorophenyl)-2-[[2-(3,4-dimethoxyphenyl)-1-methylethyl] amino[ethanol] To a benzene solution (10 ml) of (R)-2-amino-1-(3-chlorophenyl)ethanol (0.52 g) was added 0.58 g of methyl=3,4-dimethoxyphenylmethyl=ketone. The mixture was subjected to reflux in an apparatus equipped with a water-trap for one hour and the produced water was removed off from the reaction system. After cooling the reaction mixture, the solvent was distilled off under reduced pressure. The residue was dissolved into 10 ml of methanol, and with cooling the resultant solution at a temperature lower than 10°C and with stirring, the resultant solution was treated with, little by little, sodium borohydride (0.14 g) with taking 30 minutes. The reaction mixture was stirred for further one hour at room temperature and the solvent was distilled off under reduced pressure. The resultant residue was dissolved into ethyl acetate and the solution was washed with water, was dried over anhydrous magnesium sulfate, and was subjected to filtration. The residue was dried by distilling off the solvent to give 1.09 g of yellow oil. A part of the oil was subjected to silica gel chromatography and the obtained compound was analyzed with high performance liquid chromatography using an optical resoluting column [column: manufactured by Daicel Chemical Industries, Ltd., Chiralpack AD (trade name)]. Accordingly, the ratio of the (R,R)-isomer relative to the (R,S)-isomer obtained by the fractional crystallization of the diastereomers was such that the former: the latter was 48:52.

Claims: A process for producing an (R)-2-amino-1-phenylethanol derivative which comprises: permitting a microorganism or a preparation thereof which is capable of acting on a compound shown by the general formula (VII) wherein R 1 , R 2 , R 3 , R 4 and R 5 represent, the same or different, a hydrogen atom, a halogen atom, an optionally substituted C 1 -C 4 alkyl group, a hydroxyl group which may be protected with a protective group, an optionally substituted alkoxy group, an optionally substituted cycloalkyloxy group, an optionally substituted aralkyloxy group, an optionally substituted aryloxy group, an optionally substituted C 1 -C 4 alkylthio group, an optionally substituted acyl group, a carboxyl group which may be protected with a protective group, an optionally substituted C 2 -C 5 alkoxycarbonyl group, a nitro group or an optionally substituted amino group, or a salt thereof, to produce a corresponding (R)-2-amino-1-phenylethanol compound shown by the general formula (IIa) wherein R 1 , R 2 , R 3 , R 4 and R 5 have the same meanings as defined above, or a salt thereof, to act on said compound or a salt thereof and harvesting or recovering the product optically active compound or a salt thereof, wherein said microorganism is a strain of microorganism selected from the group consisting of microorganisms belonging to the genus Candida , the genus Lodderomyces, the genus Catenuloplanes , the genus Pilimelia , the genus Saccharothrix , the genus Seratia , the genus Enterococ cus, the genus Lactobacillus , the genus Pediococcus and the genus Lactococcus . A process for producing an (R)-2-amino-1-phenylethanol derivative according to claim 1, wherein said microorganism is a strain of microorganism selected from the group consisting of microorganisms belonging to Candida maltosa, Lodderomyces elongisporus, Catenuloplanes japonicus , Pilimelia terevasa, Saccharothrix australiensis , Seratia marcescens, Enterococcus faecalis, Lactobacillus casei subsp. casei , Pediococcus acidilactici and Lactococcus lactis subsp. lactis. A process for producing an (R,R)-1-phenyl-2-[(2-phenyl-1-alkylethyl)amino]ethanol derivative shown by the general formula (XI) wherein R 1 , R 2 , R 3 , R 4 and R 5 represent, the same or different, a hydrogen atom, a halogen atom, an optionally substituted C 1 -C 4 alkyl group, a hydroxyl group which may be protected with a protective group, an optionally substituted alkoxy group, an optionally substituted cycloalkyloxy group, an optionally substituted aralkyloxy group, an optionally substituted aryloxy group, an optionally substituted C 1 -C 4 alkylthio group, an optionally substituted acyl group, a carboxyl group which may be protected with a protective group, an optionally substituted C 2 -C 5 alkoxycarbonyl group, a nitro group or an optionally substituted amino group; and Z represents a hydrogen atom or a protective group for hydroxyl group; R 7 and R 8 represent, (A) respectively, a group selected from the group consisting of a hydrogen atom, an optionally substituted C 1 -C 4 alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aralkyl group, an optionally substituted aryl group, an optionally substituted acyl group, a carboxyl group which may be protected with a protective group, an optionally substituted C 2 -C 5 alkoxycarbonyl group, an optionally substituted amino group, an optionally substituted alkylsulfonyl group, an optionally substituted arylsulfonyl group and a hydroxyl group which may be protected with a protective group, or (B) R 7 represents a group shown by the formula (IX): -O-R 7a , and R 8 represents a group shown by the formula (X): -O-R 8a, wherein R 7a and R 8a may form an optionally substituted ring with the adjacent oxygen atoms; R 6 , R 9 and R 10 independently represent a group selected from a group consisting of a hydrogen atom, a halogen atom, an optionally substituted C 1 -C 4 alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aralkyl group, an optionally substituted aryl group, a hydroxyl group which may be substituted with a protective group, an optionally substituted alkoxy group, an optionally substituted cycloalkyloxy group, an optionally substituted aralkyloxy group, an optionally substituted aryloxy group, an optionally substituted C 1 -C 4 alkylthio group, an optionally substituted aralkylthio group, an optionally substituted acyl group, a carboxyl group which may be protected with a protective group, an optionally substituted C 2 -C 5 alkoxycarbonyl group, a nitro group and an optionally substituted amino group; and R 11 represents a C 1 -C 4 alkyl group, which comprises: a reaction of an (R)-2-amino-1-phenylethanol compound shown by the general formula (II) wherein R 1 , R 2 , R 3 , R 4 , R 5 and Z have the same meanings as defined above, or a salt thereof, with a compound shown by the general formula (VIII) wherein R 6 , R 7 , R 8 , R 9 , R 10 and R 11 have the same meanings as defined above, and a reducing reaction of the reaction product of said reaction, which further comprises: (1) a step of permitting a microorganism or a preparation thereof which is capable or acting on a compound shown by the general formula (VII) wherein R 1 , R 2 , R 3 , R 4 and R 5 have the same meanings as defined above, or a salt thereof to produce a corresponding (R)-2-amino-1-phenylethanol compound shown by the general formula (IIa) wherein R 1 , R 2 , R 3 , R 4 and R 5 have the same meanings as defined above, or a salt thereof, to act on said compound or a salt thereof, to produce the product optically active compound of the general formula (II) where Z represent a hydrogen atom, or a salt thereof or (2) further to said step (1), a step of introducing a protective group to the hydroxyl group of the optically active compound of the general formula (II) wherein Z represents a hydrogen atom or a salt thereof produced in said step (1), to produce the optically active compound of the general formula (II) where Z represents a protective group for hydroxyl group, or a salt thereof, wherein said microorganism is a strain of microorganism as used in Claim 1. A process for producing an (S)-2-amino-1-phenylethanol derivative which comprises: permitting a microorganism or a preparation thereof which is capable of acting on a compound shown by the general formula (VII) wherein R 1 , R 2 , R 3 , R 4 and R 5 represent, the same or different, a hydrogen atom, a halogen atom, an optionally substituted C 1 -C 4 alkyl group, a hydroxyl group which may be protected with a protective group, an optionally substituted alkoxy group, an optionally substituted cycloalkyloxy group, an optionally substituted aralkyloxy group, an optionally substituted aryloxy group, an optionally substituted C 1 -C 4 alkylthio group, an optionally substituted acyl group, a carboxyl group which may be protected with a protective group, an optionally substituted C 2 -C 5 alkoxycarbonyl group, a nitro group or an optionally substituted amino group, or a salt thereof, to produce a corresponding optically active compound shown by the general formula (XV) wherein R 1 , R 2 , R 3 , R 4 and R 5 have the same meanings as defined above, or a salt thereof, to act on said compound or a salt thereof, and harvesting or recovering the product optically active compound shown by the general formula (XV) or a salt thereof, wherein said microorganism is a strain of microorganism selected from the group consisting of the microorganisms belonging to the genus Botryoascus, the genus Brettano myces, the genus Candida , the genus Citeromyces , the genus Clavispora , the genus Debaryomyces , the genus Dipodascus , the genus Eremascus, the genus Galactomyces , the genus Geotrichum, the genus Issatchenkia , the genus Kluyveromyces , the genus Kondoa, the genus Lipomyces, the genus Malassezia , the genus Oosporidium, the genus Pachysolen , the genus Pichia, the genus Rhodosporidium, the genus Rhodotorula , the genus Saccharomyces, the genus Saccharomycodes , the genus Saccharomycopsis , the genus Schizoblastosporion , the genus Schizosaccharomyces , the genus Sporidiobolus , the genus Sporobolomyces , the genus Wickerhamiella, the genus Wingea , the genus Zygosaccharomyces , the genus Bacillus , the genus Comamonas , the genus Rhodobacter , the genus Enterococcus, the genus Lactobacillus , the genus Pediococcus , the genus Leuconostoc and the genus Streptococcus. A process for producing an (S)-2-amino-1-phenylethanol derivative according to claim 4, wherein said microorganism is a strain of microorganism selected from the group consisting of the microorganisms belonging to Botryoascus synnaedendrus, Brettanomyces anomalus, Candida albicans, Candida beechii, Candida ergatensis, Candida fusiformata, Candida guilliermondii, Candida halonitratophila, Candida oregonensis, Candida peltata, Candida parapsilosis, Candida sorboxylosa, Citeromyces matritensis, Clavispora lusitaniae, Debaryomyces hansenii var. hansanii, Dipodascus ovetensis, Eremascus fertilis, Galactomyces reessii, Geotrichum fermentans, Geotrichum candidum, Geotrichum capitatum, Geotrichum klebahnii, Issatchenkia scutulata var. scutulata, Kluyveromyces lactis, Kluyveromyces marxianus var. bulgaricus, Kondoa malvinella, Lipomyces starkeyi, Malassezia furfur, Oosporidium margaritiferum, Pachysolen tannophilus, Pichia farinosa, Pichia holstii, Pichia subpelliculosa, Pichia toletana, Rhodosporidium diobovatum, Rhodotorula glutinis, Rhodotorula glutinis var. dairenensis, Saccharomyces kluyveri, Saccharomyces paradoxus, Saccharomycodes ludwigii , Saccharomycopsis capsularis, Schizoblastosporion kobayasii, Schizosaccharomyces pombe, Sporidiobolus pararoseus, Sporobolomyces pararoseus, Sporobolomyces salmonicolor, Wickerhamiella domercquii, Wingea robertsii, Zygosaccharomyces bailii, Zygosaccharomyces fermentati, Bacilus subtilis, Comamonas terrigena, Rhodobacter sphaeroides, Enterococcus faecalis, Lactobacillus lactis, Pediococcus acidilactici, Leuconostoc mesenteroides subsp. dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos and Streptpcoccus uberis. A use of a microorganism or a preparation derived therefrom, which is capable of asymmetrically reducing a compound shown by the general formula (VII) wherein R 2 , R 2 , R 3 , R 4 and R 5 represent, the same or different, a group selected from the group consisting of a hydrogen atom, a halogen atom, an optionally substituted C 1 -C 4 alkyl group, a hydroxyl group which may be protected with a protective group, an optionally substituted alkoxy group, an optionally substituted cycloalkyloxy group, an optionally substituted aralkyloxy group, an optionally substituted aryloxy group, an optionally substituted C 1 -C 4 alkylthio group, an optionally substituted acyl group, a carboxyl group which may be protected with a protective group, an optionally substituted C 2 -C 5 alkoxycarbonyl group, a nitro group and an optionally substituted amino group or a salt thereof, to produce a corresponding (R)-2-amino-1-phenylethanol compound shown by the general formula (IIa) wherein R 1 , R 2 , R 3 , R 4 and R 5 have the same meanings as defined above, or a salt thereof, for the production of the (R)-2-amino-1-phenylethanol derivative or a salt thereof, wherein said microorgarism is a strain of microorganism as used in Claim 1. A use of a microorganism or a preparation derived therefrom, which is capable of asymmetrically reducing a compound shown by the general formula (VII) wherein R 1 , R 2 , R 3 , R 4 and R 5 have the same meanings as defined in claim 6, or a selt thereof, to produce a corresponding (S)-2-amino-1-phenylethanol compound shown by the general formula (XV) wherein R 1 , R 2 , R 3 , R 4 and R 5 have the same meanings as defined above, or a salt thereof, for the production of the (S)-2-amino-1-phenylethanol derivative or a salt thereof; wherein said microorganism is a strain of microorganism as used in claim 4.

Inventors: ABE TAKAYUKI, AKAMATSU HIDEKAZU, FURUKAWA KAZUAKI, IKURA KIYOSHI, ISHIGURO TAKESHI, ITO MICHIO, MATSUYAMA AKINOBU, MIKI KATSUYA, YAMASAKI NORITSUGU, ABE, TAKAYUKI, AKAMATSU, HIDEKAZU, FURUKAWA, KAZUAKI, IKURA, KIYOSHI, ISHIGURO, TAKESHI, ITO, MICHIO, MATSUYAMA, AKINOBU, MIKI, KATSUYA, YAMASAKI, NORITSUGU
Applicants: DAICEL CHEM, DAICEL CHEMICAL INDUSTRIES, LTD.
Application year: 1994
Main classification: C12P13
IPC codes: C07C215, C12P13, C12P41, C12P7, C07C213, C07C231