ORAL COMPOSITIONS CONTAINING TRICLOSAN FOR THE TREATMENT OF APHTHOUS ULCERS

Abstract: The present invention relates to the use of Triclosan in the manufacture of a composition for the prevention, inhibition and/or reduction of aphthous ulcers. Preferably, the compositions are oral compositions such as toothpastes and mouthwashes. The oral composition is especially preferably in a gel form. Preferably the Triclosan is used together with a zinc salt such as zinc citrate, and or a polymer that enhances the delivery of the Triclosan.

Description: ORAL COMPOSITIONS CONTAINING TRICLOSAN FOR THE TREATMENT OF APHTHOUS ULCERS. The present invention relates to the prevention, inhibition and/or reduction of minor recurrent aphthous stomatitis by the use of an oral composition which comprises Triclosan (= 2 ' ,4, 4 '-trichloro-2-hydroxy-diphenyl-ether) . Aphthous stomatitis is a general term describing a disease affecting the mucous membrane in the mouth, causing the formation of small, whitish ulcers, called aphthae or more commonly aphthous ulcers. These aphthous ulcers cause severe discomfort to the patient as they are rather painful and irritating. Several treatments for aphthous ulcers have already been proposed, e.g. gargle compositions with an astringent material or with cellulosealkylethers or with ho ocarnosine, but none of these treatments have found wide usage as effective anti-aphthae treatments. We have now found that Triclosan has a considerable anti- aphthae activity, significantly preventing, inhibiting and/or reducing the formation of aphthous ulcers in the mouth. Consequently, the present invention relates to the use of Triclosan in the manufacture of composition for preventing inhibiting and/or reducing aphthous ulcers. Triclosan is a well-known anti-bacterial agent, used in oral compositions to reduce or inhibit the growth of dental plaque. Its use to prevent, inhibit and/or reduce aphthous ulcers has not been indicated in the prior art as far as we know. The Triclosan-containing composition of the present invention can be manufactured in any form, suitable for orally administering the composition to achieve the prevention, inhibition and/or reduction of aphthous ulcers. Such forms are tablets, capsules, pills, powders, granules, solutions, gargles, suspensions, salves, gels, pastes etc. Preferably, the composiion is an oral composition. Particularly suitable forms of the oral composition are toothpastes, mouthwashes, gels and the like. Also it is possible to formulate the oral composition in forms, suitable for buccal administration, such as irrigator fluids, chewing gum, lozenges, and adhesive strips. Oral compositions in gel form are particularly preferred in the present invention. The amount of Triclosan used in the present invention may vary from 0.0001 - 5% by weight, preferably from 0.01 - 3% by weight and particularly preferably from 0.1 - 2% by weight of the oral composition. The oral composition may furthermore comprise, conventional ingredients, such as pharmaceutically acceptable carriers like starch, sucrose, polyols, surfactants, water or water/alcohol systems etc. When formulated into a dentifrice, such formulation may contain all the usual dentifrice ingredients. Thus, they may comprise particulate abrasive materials such as silicas, aluminas, calcium carbonates, dicalciumphosphates, hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates and so on, usually in amounts between 5 and 60% by weight. Furthermore, the dentifrice formulations may comprise humectants such as glycerol, sorbitol, propyleneglycol, lactitol and so on. Surface-active agents may also be included such as anionic, nonionic, amphoteric and zwitterionic synthetic detergents. Examples thereof are sodiumlaurylsulphate, sodium dodecylbenzenesulphonate, sodium mono- and dioctyl- phosphate, sodiumlauroylsarcosinate. Binders and thickeners such as sodium carboxymethyl- cellulose, xanthan gum, gum arabic etc. may also be included, as well as synthetic polymers such as polyacrylates and carboxyvinyl polymers such as Carbopol®. Flavours such as peppermint and spearmint oils may also be included, as well as preservatives, opacifying agents, colouring agents, pH-adjusting agents, sweetening agents and so on. Other anti-bacterial agents may also be included such as chlorhexidine, copper-, zinc- and stannous salts such as zinc citrate and stannous pyrophosphate, sanguinarine extract, metronidazole. Further examples of anti-bacterial agents are quaternary ammonium compounds such as cetylpyridinium chloride; bis-guanides such as chlorhexidine digluconate, hexetidine, octenidine, alexidine; halogenated bisphenolic compounds such as 2,2' methylenebis-(4-chloro-6-bromophenol) . Polymeric compounds which can enhance the delivery of active ingredients such as the anti-bacterial agents can also be included. Examples of such polymers are copolymers of polyvinyl ethylether with aleic anhydride and other similar delivery enhancing polymers, e.g. those described in DE-A-3,942,643 (Colgate) Furthermore anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin etc. may also be included. Anti-caries agents such as sodium- and stannous fluoride, aminefluorides, monosodiumfluorophosphate, calcium lactate and/or calcium glycerophosphates, strontium salts and strontium polyacrylates, casein and casein digests and phosphoproteins may also be included. Other optional ingredients include vitamins such as Vitamin C, plant extracts, potassium salts such as potassium citrate, potassium chloride and potassium nitrate. Other optional ingredients include enzymes such as dextranase and/or mutanase, a yloglucosidase, glucose- oxidase with lactoperoxidaεe, neuraminidases, and hydrogenperoxide generating compounds such as potassiumperoxydiphosphate. Furthermore, the oral compositions may comprise anti- calculus agents such as alkalimetalpyrophosphates, hypophosphite-containing polymers, organic phosphonates, phosphocitrates etc.. Other optional ingredients that may be included are e.g. bacteriocins, bacteriophages, tissue respiratory factors, antibodies, bleaching agents such as peroxy compounds, effervescing systems such as sodiumbicarbonate/citric acid systems, colour change systems, and so on. Preferred compositions for use in the present invention contain Triclosan together with a zinc salt such as zinc citrate. The amount of zinc salt used in such combination ranges from 0.01 - 5% by weight of the composition, preferably from 0.1 - 3% by weight of the composition. Other suitable zinc salts are those, disclosed in US-A- 4,022,880, as well as alkalimetal zinc citrates such as sodium zinc citrate. Also preferred for use in the present invention are compositions which contain Triclosan and a copolymer of polyvinylmethylether with maleic anhydride or another delivery-enhancing polymer as described in DE-A-3 , 942 , 643. The amount of such polymer may vary from 0.005-4% by weight of the composition. A zinc salt may also be present in these polymer-containing compositions, such as zinc citrate or zinc glycinate in the above specified amounts. The invention will further be illustrated by the following Examples: Example 1 The following formulation is a toothpaste formulation that reduces aphthous ulcers: wt % Sorbitol, 70 % syrup 45.00 Abrasive silica 10.00 Thickening silica 10.00 Xanthan gum 1.00 Saccharin 0.20 Titanium dioxide 1.00 Sodium monofluorophosphate 0.80 Flavour 1.00 Polyethylene glycol 5.00 Zinc citrate.3H 2 0 0.75 Triclosan 0.30 Water q.s. Example 2 The following compositions are mouthwash formulations that reduce aphthous ulcers: Ingredients by weight Glycerol (85 % w/w) Propylene glycol Glycine Sodium fluoride Sorbitol syrup (70 % w/w) ethanol Nonionic block copolymer surfactant Sodium hydroxide Sodium lauryl sulphate Saccharin ethoxylated hydrogenated castor oil Flavour Zinc sulphate heptahydrate Triclosan Blue Dye Water

Claims: Tentative Claims 1. Use of Triclosan in the manufacture of a composition for the prevention, inhibition and/or reduction of aphthous ulcers. 2. Use according to claim 1, characterised in that the composition is an oral composition. 3. Use according to claim 2, characterised in that the oral composition is a dentifrice or a mouthwash. 4. Use according to claim 2, characterised in that the oral composition is in a gel form. 5. Use according to claims 1-4, characterised in that the composition furthermore comprises a zinc salt. 6. Use according to claims 1-5, characterised in that the composition furthermore comprises a polymer which enhances the delivery of the Triclosan.

Inventors: CUMMINS DIANE, TRAUDT MICHAEL DAVID, VAN DER OUDERAA FRANCISCUS JOH, CUMMINS, DIANE, TRAUDT, MICHAEL, DAVID, VAN DER OUDERAA, FRANCISCUS, JOHANNES, G.
Applicants: UNILEVER NV, UNILEVER PLC, UNILEVER N.V.
Application year: 1994
Main classification: A61K31
IPC codes: A61K8, A61K31, A61K33, A61Q11